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大竹 寛雅大学院医学研究科 医科学専攻教授
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■ 受賞- 2009年03月 Kobe University Graduate School of Medicine, Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine., Young Authorship Acheivement Award: JACC Intervention, Local Determinants of Thrombus Formation Following Sirolimus-Eluting Stent Implantation Assessed by Optical Coherence Tomography
- BACKGROUND: ATP citrate lyase (ACLY) is a key enzyme in de novo lipogenesis that generates acetyl-CoA from citrate. Although fatty acids are required for energy production and biomass synthesis in the heart, the regulatory mechanisms of ACLY-mediated de novo lipogenesis in pathological cardiac fibroblasts remain unknown. The aim of this study was to investigate the biological role of ACLY in cardiac remodeling. METHODS: Adeno-associated virus serotype 9-mediated shRNA targeting Acly was intravenously injected into C57BL/6J male mice. The mice were subsequently continuously infused with a mixture of angiotensin II and phenylephrine. Cardiac phenotypes were evaluated via histological staining. Cell proliferation assays, stable isotope tracing with 13C-labeled glucose, and chromatin immunoprecipitation assays were performed using human cardiac fibroblasts. RESULTS: ACLY expression was upregulated in the heart sections of mice treated with angiotensin II/phenylephrine, in particular in fibrotic areas. Masson trichrome staining revealed that Acly gene silencing significantly reduced cardiac fibrosis in these mice. Both siRNA-mediated ACLY knockdown and pharmacological ACLY inhibition suppressed the proliferation and expression of fibrous proteins in cultured human cardiac fibroblasts stimulated with transforming growth factor-β. Mechanistically, ACLY inhibition reduced de novo lipogenesis, limiting the fatty acid supply essential for cellular growth and proliferation. It also decreased H3K9 and H3K27 acetylation, in addition to the presence of acetylated H3K9 and H3K27 at the promoter regions of fibrotic genes. CONCLUSIONS: Our findings demonstrate that ACLY plays an important role in maladaptive cardiac fibrosis. ACLY could be a novel therapeutic target to prevent the development of heart failure.Ovid Technologies (Wolters Kluwer Health), 2025年03月, Hypertension研究論文（学術雑誌）
- BACKGROUND: Coronary artery calcium score (CACS) is widely used for risk stratification. However, in patients with established coronary artery disease, its clinical implication and relationship with plaque vulnerability are unclear. We sought to correlate the CACS and plaque vulnerability assessed by optical coherence tomography. METHODS: Patients with coronary artery disease who had CACS and optical coherence tomography before percutaneous coronary intervention were included. Patients were divided into 5 groups based on CACS: CACS of 0, 1 to 99, 100 to 399, 400 to 999, and ≥1000. Optical coherence tomography-derived vulnerable features in culprit plaque were compared between the groups. RESULTS: In 460 patients, the prevalence of lipid-rich plaque, macrophage, and cholesterol crystal significantly differed among the 5 groups, being lowest in the patients with a CACS of 0. The prevalence of thin-cap fibroatheroma tended to be lower in those with a CACS of 0. No significant difference in vulnerable features was observed between the 4 groups with CACS >0. In the 2-group comparison between the group with a CACS of 0 and the other 4 groups combined, the prevalence of lipid-rich plaque (60.5% versus 85.9%; P<0.001), macrophage (48.8% versus 74.1%; P<0.001), thin-cap fibroatheroma (16.3% versus 35.0%; P=0.013), and cholesterol crystal (11.6% versus 32.9%; P=0.004) was significantly lower in the patients with CACS of 0. CACS of 0 was independently negatively associated with lipid-rich plaque, macrophage, thin-cap fibroatheroma, and cholesterol crystal after adjustment for patient characteristics. CONCLUSIONS: Patients with a CACS of 0 have a significantly lower prevalence of vulnerable plaque features compared with those with CACS >0 in patients with established coronary artery disease. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04523194.2024年12月, Circulation. Cardiovascular imaging, e017099, 英語, 国際誌研究論文（学術雑誌）
- AIMS: Optical coherence tomography (OCT) can identify high-risk plaques indicative of worsening prognosis in patients with acute coronary syndrome (ACS). However, manual OCT analysis has several limitations. In this study, we aim to construct a deep-learning model capable of automatically predicting ACS prognosis from patient OCT images following percutaneous coronary intervention (PCI). METHODS AND RESULTS: Post-PCI OCT images from 418 patients with ACS were input into a deep-learning model comprising a convolutional neural network (CNN) and transformer. The primary endpoint was target vessel failure (TVF). Model performances were evaluated using Harrell's C-index and compared against conventional models based on human observation of quantitative (minimum lumen area, minimum stent area, average reference lumen area, stent expansion ratio, and lesion length) and qualitative (irregular protrusion, stent thrombus, malapposition, major stent edge dissection, and thin-cap fibroatheroma) factors. GradCAM activation maps were created after extracting attention layers by using the transformer architecture. A total of 60 patients experienced TVF during follow-up (median 961 days). The C-index for predicting TVF was 0.796 in the deep-learning model, which was significantly higher than that of the conventional model comprising only quantitative factors (C-index: 0.640) and comparable to that of the conventional model, including both quantitative and qualitative factors (C-index: 0.789). GradCAM heat maps revealed high activation corresponding to well-known high-risk OCT features. CONCLUSION: The CNN and transformer-based deep-learning model enabled fully automatic prognostic prediction in patients with ACS, with a predictive ability comparable to a conventional survival model using manual human analysis. CLINICAL TRIAL REGISTRATION: The study was registered in the University Hospital Medical Information Network Clinical Trial Registry (UMIN000049237).2024年11月, European heart journal. Digital health, 5(6) (6), 692 - 701, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Coronary artery calcification is an integral part of atherosclerosis. It has been suggested that early coronary artery calcification is associated with active inflammation, and advanced calcification forms as inflammation subsides. Inflammation is also an important factor in plaque vulnerability. However, the relationship between coronary artery calcium burden, vascular inflammation, and plaque vulnerability has not been fully investigated. OBJECTIVES: This study aimed to correlate calcified plaque burden (CPB) at the culprit lesion with vascular inflammation and plaque vulnerability. METHODS: Patients with coronary artery disease who had both computed tomography angiography and optical coherence tomography were included. The authors divided the patients into 4 groups: 1 group without calcification at the culprit lesion; and 3 groups based on the CPB tertiles. CPB was calculated as calcified plaque volume divided by vessel volume in the culprit lesion. The authors compared pericoronary adipose tissue (PCAT) attenuation for vascular inflammation and optical coherence tomography-derived vulnerable features among the 4 groups. RESULTS: Among 578 patients, the highest CPB tertile showed significantly lower PCAT attenuation of culprit vessel compared with the other groups. The prevalence of features of plaque vulnerability (including lipid-rich plaque, macrophage, and microvessel) was also lowest in the highest CPB tertile. In the patients with calcification, higher age, statin use, and lower PCAT attenuation were independently associated with CPB. CONCLUSIONS: Greater calcium burden is associated with a lower level of vascular inflammation and plaque vulnerability. A greater calcium burden may represent advanced stable plaque without significant inflammatory activity. (Massachusetts General Hospital and Tsuchiura Kyodo General Hospital Coronary Imaging Collaboration; NCT04523194).2024年10月, JACC. Cardiovascular imaging, 17(10) (10), 1214 - 1224, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Vulnerable plaque presents prognostic implications in addition to functional significance. OBJECTIVES: The aim of this study was to identify relevant features of vulnerable plaque in functionally significant lesions. METHODS: In this multicenter, prospective study conducted across 5 countries, including patients who had invasive fractional flow reserve (FFR) ≤0.80, a total of 95 patients with available pullback pressure gradient (PPG) and plaque analysis on coronary computed tomographic angiography and optical coherence tomography were analyzed. Vulnerable plaque was defined as the presence of plaque rupture or thin-cap fibroatheroma on optical coherence tomography. Among the 25 clinical characteristics, invasive angiographic findings, physiological indexes, and coronary computed tomographic angiographic findings, significant predictors of vulnerable plaque were identified. RESULTS: Mean percentage diameter stenosis, FFR, and PPG were 77.8% ± 14.6%, 0.66 ± 0.13, and 0.65 ± 0.13, respectively. Vulnerable plaque was present in 53 lesions (55.8%). PPG and FFR were identified as significant predictors of vulnerable plaque (P < 0.05 for all). PPG >0.65 and FFR ≤0.70 were significantly related to a higher probability of vulnerable plaque after adjustment for each other (OR: 6.75 [95% CI: 2.39-19.1]; P < 0.001] for PPG >0.65; OR: 4.61 [95% CI: 1.66-12.8]; P = 0.003 for FFR ≤0.70). When categorizing lesions according to combined PPG >0.65 and FFR ≤0.70, the prevalence of vulnerable plaque was 20.0%, 57.1%, 66.7%, and 88.2% in the order of PPG ≤0.65 and FFR >0.70, PPG ≤0.65 and FFR ≤0.70, PPG >0.65 and FFR >0.70, and PPG >0.65 and FFR ≤0.70 (P for trend < 0.001), respectively. CONCLUSIONS: Among low-FFR lesions, the presence of vulnerable plaque can be predicted by PPG combined with FFR without additional anatomical or plaque characteristics. (Precise Percutaneous Coronary Intervention Plan [P3] Study; NCT03782688).2024年09月, JACC. Cardiovascular imaging, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: The clinical benefits of optical frequency domain imaging (OFDI)-guided percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) remain unclear. AIMS: We sought to compare intravascular ultrasound (IVUS)- and OFDI-guided PCI in patients with ACS. METHODS: OPINION ACS is a multicentre, prospective, randomised, non-inferiority trial that compared OFDI-guided PCI with IVUS-guided PCI using current-generation drug-eluting stents in ACS patients (n=158). The primary endpoint was in-stent minimum lumen area (MLA), assessed using 8-month follow-up OFDI. RESULTS: Patients presented with ST-segment elevation myocardial infarction (55%), non-ST-segment elevation myocardial infarction (29%), or unstable angina pectoris (16%). PCI procedural success was achieved in all patients, with comparably low periprocedural complications rates in both groups. Immediately after PCI, the minimum stent area (p=0.096) tended to be smaller for OFDI versus IVUS guidance. Proximal stent edge dissection (p=0.012) and irregular protrusion (p=0.03) were significantly less frequent in OFDI-guided procedures than in IVUS-guided procedures. Post-PCI coronary flow, assessed using corrected Thrombolysis in Myocardial Infarction frame counts, was significantly better in the OFDI-guided group than in the IVUS-guided group (p<0.001). The least squares mean (95% confidence interval [CI]) in-stent MLA at 8 months was 4.91 (95% CI: 4.53-5.30) mm2 and 4.76 (95% CI: 4.35-5.17) mm2 in the OFDI- and IVUS-guided groups, respectively, demonstrating the non-inferiority of OFDI guidance (pnon-inferiority<0.001). The average neointima area tended to be smaller in the OFDI-guided group. The frequency of major adverse cardiac events was similar. CONCLUSIONS: Among ACS patients, OFDI-guided PCI and IVUS-guided PCI were equally safe and feasible, with comparable in-stent MLA at 8 months. OFDI guidance may be a potential option in ACS patients. This study was registered in the Japan Registry of Clinical Trials (jrct.niph.go.jp: jRCTs052190093).2024年09月, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 20(17) (17), e1086-e1097, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Combining morphological and physiological evaluations might improve the risk stratification of patients who undergo percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) culprit lesions. AIMS: We aimed to investigate the clinical utility of morphofunctional evaluation after PCI for identifying ACS patients with increased risk of subsequent clinical events. METHODS: We retrospectively studied 298 consecutive ACS patients who had undergone optical coherence tomography (OCT)-guided PCI. We performed OCT-based morphological analysis and quantitative flow ratio (QFR)-based physiological assessment immediately after PCI. The non-culprit segment (NCS) was defined as the most stenotic untreated segment in the culprit vessel. The primary outcome was target vessel failure (TVF), a composite of cardiac death, target vessel-related myocardial infarction, and ischaemia-driven target vessel revascularisation. RESULTS: During a median follow-up period of 990 days, 42 patients experienced TVF. Cox regression analysis revealed that the presence of thin-cap fibroatheroma (TCFA) in the NCS and a low post-PCI QFR, or the presence of TCFA in the NCS and a high ΔQFR in the NCS (QFRNCS), were independently associated with TVF. The subgroup with TCFA in the NCS and a low post-PCI QFR had a significantly higher incidence of TVF (75%) than the other subgroups, and those with TCFA in the NCS and a high ΔQFRNCS had a significantly higher incidence of TVF (86%) than the other subgroups. The integration of TCFA in NCS, post-PCI QFR, and ΔQFRNCS with traditional risk factors significantly enhanced the identification of subsequent TVF cases. CONCLUSIONS: Combining post-PCI OCT and QFR evaluation may enhance risk stratification for ACS patients after successful PCI, particularly in predicting subsequent TVF.2024年08月, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 20(15) (15), e927-e936, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Acute coronary syndrome (ACS) involves plaque-related thrombosis, causing primary ischemic cardiomyopathy or lethal arrhythmia. We previously demonstrated a unique immune landscape of myeloid cells in the culprit plaques causing ACS by using single-cell RNA sequencing. Here, we aimed to characterize T cells in a single-cell level, assess clonal expansion of T cells, and find a therapeutic target to prevent ACS. METHODS: We obtained the culprit lesion plaques from 4 patients with chronic coronary syndrome (chronic coronary syndrome plaques) and the culprit lesion plaques from 3 patients with ACS (ACS plaques) who were candidates for percutaneous coronary intervention with directional coronary atherectomy. Live CD45+ immune cells were sorted from each pooled plaque samples and applied to the 10× platform for single-cell RNA sequencing analysis. We also extracted RNA from other 3 ACS plaque samples and conducted unbiased TCR (T-cell receptor) repertoire analysis. RESULTS: CD4+ T cells were divided into 5 distinct clusters: effector, naive, cytotoxic, CCR7+ (C-C chemokine receptor type 7) central memory, and FOXP3 (forkhead box P3)+ regulatory CD4+ T cells. The proportion of central memory CD4+ T cells was higher in the ACS plaques. Correspondingly, dendritic cells also tended to express more HLAs (human leukocyte antigens) and costimulatory molecules in the ACS plaques. The velocity analysis suggested the differentiation flow from central memory CD4+ T cells into effector CD4+ T cells and that from naive CD4+ T cells into central memory CD4+ T cells in the ACS plaques, which were not observed in the chronic coronary syndrome plaques. The bulk repertoire analysis revealed clonal expansion of TCRs in each patient with ACS and suggested that several peptides in the ACS plaques work as antigens and induced clonal expansion of CD4+ T cells. CONCLUSIONS: For the first time, we revealed single cell-level characteristics of CD4+ T cells in patients with ACS. CD4+ T cells could be therapeutic targets of ACS. REGISTRATION: URL: https://upload.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000046521; Unique identifier: UMIN000040747.2024年05月, Arteriosclerosis, thrombosis, and vascular biology, 44(5) (5), 1135 - 1143, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Elsevier BV, 2024年05月, Journal of Cardiovascular Computed Tomography研究論文（学術雑誌）
- 2024年05月, Journal of cardiovascular computed tomography, 英語, 国際誌
- BACKGROUND: Fractional flow reserve-computed tomography (FFRCT) has not been validated in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) for coronary artery disease due to theoretical difficulties in using nitroglycerin for such patients.Methods and Results: In this single-center study, we prospectively enrolled 21 patients (34 vessels) and performed pre-TAVR FFRCTwithout nitroglycerin, pre-TAVR invasive instantaneous wave-free ratio (iFR) measurements, and post-TAVR FFR measurements using a pressure wire. The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of pre-TAVR FFRCT≤0.80 to predict post-TAVR invasive FFR ≤0.80 were 82%, 83%, 82%, 71%, and 90%, respectively. A receiver operating characteristic analysis demonstrated an optimal cutoff of 0.78 for pre-TAVR FFRCTto indicate post-TAVR FFR ≤0.80, with an area under the curve (AUC) of 0.84, and the counterpart cutoff of pre-TAVR iFR was 0.89 with an AUC of 0.86. CONCLUSIONS: FFRCTwithout nitroglycerin could be a useful non-invasive imaging modality for assessing the severity of coronary artery lesions in patients with severe AS.2024年03月, Circulation journal : official journal of the Japanese Circulation Society, 88(4) (4), 501 - 509, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Murray law-based quantitative flow ratio (μQFR) is a novel computational method that enables accurate estimation of fractional flow reserve (FFR) using a single angiographic projection. However, its diagnostic value in patients with severe aortic stenosis (AS) remains unclear. METHOD: We included 25 consecutive patients who underwent transcatheter aortic valve replacement (TAVR) for severe AS with intermediate or greater (30-90%) coronary artery disease (CAD). Pre- and post-TAVR μQFR, QFR, instantaneous flow reserve (iFR), and post-TAVR invasive FFR values were measured. We evaluated the diagnostic performance of pre-TAVR μQFR, QFR, and iFR using post-TAVR FFR ≤ 0.80 as a reference standard of ischemia. RESULT: Pre-TAVR μQFR was significantly correlated with post-TAVR FFR (r = 0.73, p < 0.0001). The area under the curve of pre-TAVR μQFR on post-TAVR FFR ≤ 0.8 was 0.91 (95% confidence interval [CI] 0.77-0.98), comparable to that of pre-TAVR iFR (0.86 [95% CI 0.71-0.98], p = 0.97). The accuracy, sensitivity, specificity, and positive and negative predictive values of pre-TAVR μQFR on post-TAVR FFR ≤ 0.8 were 84.2% (95% CI 68.7-93.4), 61.6% (95% CI 31.6-86.1), 96.0% (95% CI 79.6-99.9), 88.9% (95% CI 52.9-98.3), and 82.8% (95% CI 70.6-90.6), respectively. For pre-TAVR iFR, these values were 76.5% (95% CI 58.8-89.3), 90.9% (95% CI 58.7-99.8), 69.6% (95% CI 47.1-86.8), 58.8% (95% CI 42.8-73.1), and 94.1% (95% CI 70.8-99.1), respectively. CONCLUSION: μQFR could be useful for the physiological evaluation of patients with severe AS with concomitant CAD.2024年03月, Heart and vessels, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND AND AIMS: Coronary hemodynamics impact coronary plaque progression and destabilization. The aim of the present study was to establish the association between focal vs. diffuse intracoronary pressure gradients and wall shear stress (WSS) patterns with atherosclerotic plaque composition. METHODS: Prospective, international, single-arm study of patients with chronic coronary syndromes and hemodynamic significant lesions (fractional flow reserve [FFR] ≤ 0.80). Motorized FFR pullback pressure gradient (PPG), optical coherence tomography (OCT), and time-average WSS (TAWSS) and topological shear variation index (TSVI) derived from three-dimensional angiography were obtained. RESULTS: One hundred five vessels (median FFR 0.70 [Interquartile range (IQR) 0.56-0.77]) had combined PPG and WSS analyses. TSVI was correlated with PPG (r = 0.47, [95% Confidence Interval (95% CI) 0.30-0.65], p < 0.001). Vessels with a focal CAD (PPG above the median value of 0.67) had significantly higher TAWSS (14.8 [IQR 8.6-24.3] vs. 7.03 [4.8-11.7] Pa, p < 0.001) and TSVI (163.9 [117.6-249.2] vs. 76.8 [23.1-140.9] m-1, p < 0.001). In the 51 vessels with baseline OCT, TSVI was associated with plaque rupture (OR 1.01 [1.00-1.02], p = 0.024), PPG with the extension of lipids (OR 7.78 [6.19-9.77], p = 0.003), with the presence of thin-cap fibroatheroma (OR 2.85 [1.11-7.83], p = 0.024) and plaque rupture (OR 4.94 [1.82 to 13.47], p = 0.002). CONCLUSIONS: Focal and diffuse coronary artery disease, defined using coronary physiology, are associated with differential WSS profiles. Pullback pressure gradients and WSS profiles are associated with atherosclerotic plaque phenotypes. Focal disease (as identified by high PPG) and high TSVI are associated with high-risk plaque features. CLINICAL TRIAL REGISTRATION: https://clinicaltrials,gov/ct2/show/NCT03782688.2024年03月, International journal of cardiology, 399, 131668 - 131668, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本循環器学会, 2024年03月, 日本循環器学会学術集会抄録集, 88回, OJ15 - 4, 英語Prognostic Significance of Nodular Calcification Derived from Non-contrast Coronary Computed Tomography in Percutaneous Coronary Intervention(タイトル和訳中)
- BACKGROUND: Following percutaneous coronary intervention (PCI), optical coherence tomography provides prognosis information. The pullback pressure gradient is a novel index that discriminates focal from diffuse coronary artery disease based on fractional flow reserve pullbacks. We sought to investigate the association between coronary artery disease patterns, defined by coronary physiology, and optical coherence tomography after stent implantation in stable patients undergoing PCI. METHODS AND RESULTS: This multicenter, prospective, single-arm study was conducted in 5 countries (NCT03782688). Subjects underwent motorized fractional flow reserve pullbacks evaluation followed by optical coherence tomography-guided PCI. Post-PCI optical coherence tomography minimum stent area, stent expansion, and the presence of suboptimal findings such as incomplete stent apposition, stent edge dissection, and irregular tissue protrusion were compared between patients with focal versus diffuse disease. Overall, 102 patients (105 vessels) were included. Fractional flow reserve before PCI was 0.65±0.14, pullback pressure gradient was 0.66±0.14, and post-PCI fractional flow reserve was 0.88±0.06. The mean minimum stent area was 5.69±1.99 mm2 and was significantly larger in vessels with focal disease (6.18±2.12 mm2 versus 5.19±1.72 mm2, P=0.01). After PCI, incomplete stent apposition, stent edge dissection, and irregular tissue protrusion were observed in 27.6%, 10.5%, and 51.4% of the cases, respectively. Vessels with focal disease at baseline had a lower prevalence of incomplete stent apposition (11.3% versus 44.2%, P=0.002) and more irregular tissue protrusion (69.8% versus 32.7%, P<0.001). CONCLUSIONS: Baseline coronary pathophysiological patterns are associated with suboptimal imaging findings after PCI. Patients with focal disease had larger minimum stent area and a higher incidence of tissue protrusion, whereas stent malapposition was more frequent in patients with diffuse disease.2024年02月, Journal of the American Heart Association, e032605, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Perivascular inflammation contributes to the development of atherosclerosis and microcirculatory dysfunction. Pericoronary adipose tissue (PCAT) attenuation, measured by coronary computed tomography angiography, is a potential indicator of coronary inflammation. However, the relationship between PCAT attenuation, microcirculatory dysfunction, and periprocedural myocardial injury (PMI) remains unclear. METHODS AND RESULTS: Patients with chronic coronary syndrome who underwent coronary computed tomography angiography before percutaneous coronary intervention were retrospectively identified. PCAT attenuation and adverse plaque characteristics were assessed using coronary computed tomography angiography. The extent of microcirculatory dysfunction was evaluated using the angio-based index of microcirculatory resistance before and after percutaneous coronary intervention. Overall, 125 consecutive patients were included, with 50 experiencing PMI (PMI group) and 75 without PMI (non-PMI group). Multivariable analysis showed that older age, higher angio-based index of microcirculatory resistance, presence of adverse plaque characteristics, and higher lesion-based PCAT attenuation were independently associated with PMI occurrence (odds ratio [OR], 1.07 [95% CI, 1.01-1.13]; P=0.02; OR, 1.06 [95% CI, 1.00-1.12]; P=0.04; OR, 6.62 [95% CI, 2.13-20.6]; P=0.001; and OR, 2.89 [95% CI, 1.63-5.11]; P<0.001, respectively). High PCAT attenuation was correlated with microcirculatory dysfunction before and after percutaneous coronary intervention and its exacerbation during percutaneous coronary intervention. Adding lesion-based PCAT attenuation to the presence of adverse plaque characteristics improved the discriminatory and reclassification ability in predicting PMI. CONCLUSIONS: Adding PCAT attenuation at the culprit lesion level to coronary computed tomography angiography-derived adverse plaque characteristics may provide incremental benefit in identifying patients at risk of PMI. Our results highlight the importance of microcirculatory dysfunction in PMI development, particularly in the presence of lesions with high PCAT attenuation. REGISTRATION: URL: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000057722; Unique identifier: UMIN000050662.2024年02月, Journal of the American Heart Association, 13(3) (3), e031209, 英語, 国際誌研究論文（学術雑誌）
- Japanese Circulation Society, 2023年10月, Circulation Journal, 87(11) (11), 1661 - 1671研究論文（学術雑誌）
- OBJECTIVE: To assess the accuracy of a virtual stenting tool based on coronary CT angiography (CCTA) and fractional flow reserve (FFR) derived from CCTA (FFRCT Planner) across different levels of image quality. MATERIALS AND METHODS: Prospective, multicenter, single-arm study of patients with chronic coronary syndromes and lesions with FFR ≤ 0.80. All patients underwent CCTA performed with recent-generation scanners. CCTA image quality was adjudicated using the four-point Likert scale at a per-vessel level by an independent committee blinded to the FFRCT Planner. Patient- and technical-related factors that could affect the FFRCT Planner accuracy were evaluated. The FFRCT Planner was applied mirroring percutaneous coronary intervention (PCI) to determine the agreement with invasively measured post-PCI FFR. RESULTS: Overall, 120 patients (123 vessels) were included. Invasive post-PCI FFR was 0.88 ± 0.06 and Planner FFRCT was 0.86 ± 0.06 (mean difference 0.02 FFR units, the lower limit of agreement (LLA) - 0.12, upper limit of agreement (ULA) 0.15). CCTA image quality was assessed as excellent (Likert score 4) in 48.3%, good (Likert score 3) in 45%, and sufficient (Likert score 2) in 6.7% of patients. The FFRCT Planner was accurate across different levels of image quality with a mean difference between FFRCT Planner and invasive post-PCI FFR of 0.02 ± 0.07 in Likert score 4, 0.02 ± 0.07 in Likert score 3 and 0.03 ± 0.08 in Likert score 2, p = 0.695. Nitrate dose ≥ 0.8mg was the only independent factor associated with the accuracy of the FFRCT Planner (95%CI - 0.06 to - 0.001, p = 0.040). CONCLUSION: The FFRCT Planner was accurate in predicting post-PCI FFR independent of CCTA image quality. CLINICAL RELEVANCE STATEMENT: Being accurate in predicting post-PCI FFR across a wide spectrum of CT image quality, the FFRCT Planner could potentially enhance and guide the invasive treatment. Adequate vasodilation during CT acquisition is relevant to improve the accuracy of the FFRCT Planner. KEY POINTS: • The fractional flow reserve derived from coronary CT angiography (FFRCT) Planner is a novel tool able to accurately predict fractional flow reserve after percutaneous coronary intervention. • The accuracy of the FFRCT Planner was confirmed across a wide spectrum of CT image quality. Nitrates dose at CT acquisition was the only independent predictor of its accuracy. • The FFRCT Planner could potentially enhance and guide the invasive treatment.2023年10月, European radiology, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: The impact of coronary bifurcation angle (BA) on incomplete stent apposition (ISA) after crossover stenting followed by side branch (SB) intervention has not been established. METHODS: A total of 100 crossover stentings randomly treated with proximal optimization technique followed by short balloon dilation in the SB (POT-SBD group, 48 patients) and final kissing balloon technique (KBT group, 52 patients) were analyzed in the PROPOT trial. Major ISA with maximum distance > 400 μm and its location was determined using optical coherence tomography before SB intervention and at the final procedure. The BA was defined as the angle between the distal main vessel and SB. Optimal POT was determined when the difference in stent volume index between the proximal and distal bifurcation was greater than the median value (0.86 mm3/mm) before SB intervention. RESULT: Major ISA was more frequently observed in the POT-SBD than in the KBT group (35% versus 17%, p < 0.05). In the POT-SBD group, worsening ISA after SBD was prominent at the distal bifurcation. The BA was an independent predictor of major ISA (odds ratio 1.04, 95% confidence interval 1.00-1.07, p < 0.05) with a cut-off value of 59.5° (p < 0.05). However, the cases treated with optimal POT in the short BA (<60°) indicated the lowest incidence of major ISA. In the KBT group, BA had no significant impact. CONCLUSION: A wide BA has a potential risk for the occurrence of major ISA after POT followed by SBD in coronary bifurcation stenting.2023年10月, International journal of cardiology. Heart & vasculature, 48, 101265 - 101265, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Drug-coated balloon (DCB) became a potential treatment option for patients with acute coronary syndrome (ACS); however, factors associated with target lesion failure (TLF) remain uncertain. METHODS: This retrospective, multicentre, observational study included consecutive ACS patients who underwent optical coherence tomography (OCT)-guided DCB treatment. Patients were divided into two groups according to the occurrence of TLF, a composite of cardiac death, target vessel-related myocardial infarction, and ischemia-driven target lesion revascularisation. RESULTS: We enrolled 127 patients in this study. During the median follow-up period of 562 (IQR: 342-1164) days, 24 patients (18.9%) experienced TLF, and 103 patients (81.1%) did not. The cumulative 3-year incidence of TLF was 22.0%. The cumulative 3-year incidence of TLF was the lowest in patients with plaque erosion (PE) (7.5%), followed by those with rupture (PR) (26.1%) and calcified nodule (CN) (43.5%). Multivariable Cox regression analysis revealed that plaque morphology was independently associated with TLF on pre-PCI (percutaneous coronary intervention) OCT, and residual thrombus burden (TB) was positively associated with TLF on post-PCI OCT. Further stratification by post-PCI TB revealed a comparable incidence of TLF in patients with PR (4.2%) to that of PE if the culprit lesion had a smaller post-PCI TB than the cut-off value (8.4%). TLF incidence was high in patients with CN, regardless of TB size on post-PCI OCT. CONCLUSIONS: Plaque morphology was strongly associated with TLF for ACS patients after DCB treatment. Residual TB post-PCI might be a key determinant for TLF, especially in patients with PR.2023年09月, International journal of cardiology, 387, 131149 - 131149, 英語, 国際誌研究論文（学術雑誌）
- Even after successful revascularization with primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI), subsequent adverse events still occur. Previous studies have suggested potential benefits of intravascular imaging, including optical coherence tomography (OCT). However, the feasibility of OCT-guided primary PCI has not been systematically examined in these patients. The ATLAS-OCT (ST-elevation Acute myocardial infarcTion and cLinicAl outcomeS treated by Optical Coherence Tomography-guided percutaneous coronary intervention) trial was designed to investigate the feasibility of OCT guidance during primary PCI for STEMI in experienced centers with expertise on OCT-guided PCI as a prospective, multicenter registry of consecutive patients with STEMI who underwent a primary PCI. The sites' inclusion criteria are as follows: (1) acute care hospitals providing 24/7 emergency care for STEMI, and (2) institutions where OCT-guided PCI is the first choice for primary PCI in STEMI. All patients with STEMI who underwent primary PCI at participating sites will be consecutively enrolled, irrespective of OCT use during PCI. The primary end point will be the rate of successful OCT imaging during the primary PCI. As an ancillary imaging modality to angiography, OCT provides morphologic information during PCI for the assessment of plaque phenotypes, vessel sizing, and PCI optimization. Major adverse cardiac events, defined as a composite of all-cause death, myocardial infarction, and target vessel revascularization at 1 year, will also be recorded. The ATLAS-OCT study will clarify the feasibility of OCT-guided primary PCI for patients with STEMI and further identify a suitable patient group for OCT-guided primary PCI.2023年08月, The American journal of cardiology, 203, 466 - 472, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本心血管インターベンション治療学会, 2023年08月, 日本心血管インターベンション治療学会抄録集, 31回, MO26 - 1, 英語経カテーテル大動脈弁置換術施行患者における冠動脈造影検査に基づく定量的冠血流比の有効性
- (一社)日本心血管インターベンション治療学会, 2023年08月, 日本心血管インターベンション治療学会抄録集, 31回, MP22 - 8, 英語OFDIを用いたロータブレータの切削効果予測の検討
- Elsevier BV, 2023年08月, JACC: Asia, 3(4) (4), 649 - 661研究論文（学術雑誌）
- This study determined the predictive accuracy of optical frequency domain imaging (OFDI) on debulking effects of rotational atherectomy (RA) and compared the predictive accuracy of OFDI catheter-based with Rota wire-based prediction methods. This prospective, single-center, observational study included 55 consecutive patients who underwent OFDI-guided RA. On pre-RA OFDI images, a circle, identical to the Rota burr was drawn at the center of the OFDI catheter (OFDI catheter-based prediction method) or wire (wire-based prediction method). The area overlapping the vessel wall was defined as the predicted ablation area (P-area). The actual ablated area (A-area) was measured by superimposing the OFDI images before and after RA. The overlapping P-area and A-area were defined as overlapped ablation area (O-area), and the predictive accuracy was evaluated by %Correct area (O-area/P-area) and %Error area (A-area - O-area/A-area). The median %Correct and %Error areas were 47.8% and 41.6%, respectively. Irrelevant ablation (low %Correct-/high % Error areas) and over ablation (high %Correct-/high % Error areas) were related to deep vessel injury and intimal flap outside the P-area. The predictive accuracy was better in the OFDI catheter-based prediction method than the wire-based prediction method in the cross sections where the OFDI catheter and wire came in contact. However, it was better in the latter than the former where the OFDI catheter and wire were not in contact. OFDI-based simulation of the RA effect is feasible though accuracy may be affected by the OFDI catheter and wire position. OFDI-based simulation of RA effect might reduce peri-procedural complications during RA.2023年07月, Cardiovascular intervention and therapeutics, 38(3) (3), 316 - 326, 英語, 国内誌研究論文（学術雑誌）
- Elsevier BV, 2023年07月, JACC: Cardiovascular Imaging研究論文（学術雑誌）
- BACKGROUND: Fractional flow reserve (FFR) measured after percutaneous coronary intervention (PCI) carries prognostic information. Yet, myocardial mass subtended by a stenosis influences FFR. We hypothesized that a smaller coronary lumen volume and a large myocardial mass might be associated with lower post-PCI FFR. AIM: We sought to assess the relationship between vessel volume, myocardial mass, and post-PCI FFR. METHODS: This was a subanalysis with an international prospective study of patients with significant lesions (FFR ≤ 0.80) undergoing PCI. Territory-specific myocardial mass was calculated from coronary computed tomography angiography (CCTA) using the Voronoi's algorithm. Vessel volume was extracted from quantitative CCTA analysis. Resting full-cycle ratio (RFR) and FFR were measured before and after PCI. We assessed the association between coronary lumen volume (V) and its related myocardial mass (M), and the percent of total myocardial mass (%M) with post-PCI FFR. RESULTS: We studied 120 patients (123 vessels: 94 left anterior descending arteries, 13 left Circumflex arteries, 16 right coronary arteries). Mean vessel-specific mass was 61 ± 23.1 g (%M 39.6 ± 11.7%). The mean post-PCI FFR was 0.88 ± 0.06 FFR units. Post-PCI FFR values were lower in vessels subtending higher mass (0.87 ± 0.05 vs. 0.89 ± 0.07, p = 0.047), and with lower V/M ratio (0.87 ± 0.06 vs. 0.89 ± 0.07, p = 0.02). V/M ratio correlated significantly with post-PCI RFR and FFR (RFR r = 0.37, 95% CI: 0.21-0.52, p < 0.001 and FFR r = 0.41, 95% CI: 0.26-0.55, p < 0.001). CONCLUSION: Post-PCI RFR and FFR are associated with the subtended myocardial mass and the coronary volume to mass ratio. Vessels with higher mass and lower V/M ratio have lower post-PCI RFR and FFR.2023年06月, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 101(7) (7), 1182 - 1192, 英語, 国際誌研究論文（学術雑誌）
- Elsevier BV, 2023年06月, Atherosclerosis, 375, 1 - 8研究論文（学術雑誌）
- 2023年05月, Cardiovascular intervention and therapeutics, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Cancer-associated thrombosis is a frequent complication of cancer; however, little evidence is available regarding the association between cancer history and coronary artery stent thrombosis (ST). We aimed to investigate the relationship between cancer history and second-generation drug-eluting stent thrombosis (G2-ST). METHODS: From the REAL-ST (Retrospective Multicenter Registry of ST After First- and Second-Generation Drug-Eluting Stent Implantation) registry, this study evaluated 1265 patients (G2- ST cases, n = 253; controls, n = 1012) with cancer-related information available. RESULTS: The prevalence of patients with cancer history was higher (12.3% vs. 8.5%, p = 0.065), and that of currently diagnosed and currently treated cancer was significantly higher in ST cases than controls (3.6% vs. 1.4%, p = 0.021; 3.2% vs. 1.3%, p = 0.037, respectively). Multivariable logistic regression analysis revealed that cancer history was associated with late ST (odds ratio [OR]: 2.80, 95% confidence intervals [CI]: 0.92-8.55, p = 0.071) and very late ST (OR: 2.40, 95% CI: 1.02-5.65, p = 0.046), but not with early ST (OR: 1.01, 95% CI: 0.51-2.00, p = 0.97). During the median follow-up period of 872 days after the index ST events, patients with cancer history showed a higher mortality than those without, among both ST cases (hazard ratio [HR]: 1.93, 95% CI: 1.06-3.51, p = 0.031) and controls (HR: 1.93, 95% CI: 1.09-3.40, p = 0.023). CONCLUSION: A post hoc analysis of REAL-ST registry revealed that patients with G2-ST had a higher prevalence of currently diagnosed and currently treated cancer. Notably, cancer history was associated with the occurrence of late and very late ST, but not with early ST.2023年05月, Thrombosis journal, 21(1) (1), 60 - 60, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Several stent expansion criteria derived from the intravascular ultrasound (IVUS) evaluation have been proposed to predict future clinical outcomes, but optimal stent expansion criteria as a guide during percutaneous coronary intervention (PCI) are still controversial. There are no studies evaluating the utility of stent expansion criteria along with the clinical and procedural factors in predicting target lesion revascularization (TLR) after contemporary IVUS-guided PCI. METHODS: OPTIVUS-Complex PCI study (Optimal Intravascular Ultrasound Guided Complex Percutaneous Coronary Intervention) multivessel cohort was a prospective multicenter study enrolling 961 patients undergoing multivessel PCI including left anterior descending coronary artery using IVUS with an intention to meet the prespecified criteria for optimal stent expansion. We compared several stent expansion criteria (minimum stent area [MSA], MSA/distal or average reference lumen area, MSA/distal or average reference vessel area, OPTIVUS criteria, IVUS-XPL [Impact of Intravascular Ultrasound Guidance on Outcomes of Xience Prime Stents in Long Lesions] criteria, ULTIMATE [Intravascular Ultrasound Guided Drug Eluting Stents Implantation in "All-Comers" Coronary Lesions] criteria, and modified MUSIC [Multicenter Ultrasound Stenting in Coronaries Study] criteria) as well as clinical, angiographic, and procedural characteristics between lesions with and without TLR. RESULTS: Among 1957 lesions, the cumulative 1-year incidence of lesion-based TLR was 1.6% (30 lesions). Hemodialysis, treatment of proximal left anterior descending coronary artery lesions, calcified lesions, small proximal reference lumen area, and small MSA had univariate associations with TLR, while all of the stent expansion criteria except for MSA were not associated with TLR. The independent risk factors of TLR were calcified lesions (hazard ratio, 2.34 [95% CI, 1.03-5.32]; P=0.04) and small proximal reference lumen area (Tertile 1: hazard ratio, 7.01 [95% CI, 1.45-33.93]; P=0.02; and Tertile 2: hazard ratio, 5.40 [95% CI, 1.17-24.90]; P=0.03). CONCLUSIONS: In contemporary IVUS-guided PCI practice, the 1-year incidence of TLR was very low. MSA, but not other stent expansion criteria, had univariate association with TLR. Independent risk factors of TLR were calcified lesions and small proximal reference lumen area, although the findings should be interpreted with caution due to small number of TLR events, limited lesion complexity, and short duration of follow-up.2023年05月, Circulation. Cardiovascular interventions, 16(5) (5), e012922, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Intravascular ultrasound (IVUS) was only rarely used in landmark trials comparing percutaneous coronary intervention (PCI) with coronary artery bypass grafting (CABG) in patients with multivessel disease. OBJECTIVES: The authors aimed to evaluate clinical outcomes after optimal IVUS-guided PCI in patients undergoing multivessel PCI. METHODS: The OPTIVUS (OPTimal IntraVascular UltraSound)-Complex PCI study multivessel cohort was a prospective multicenter single-arm study enrolling 1,021 patients undergoing multivessel PCI, including left anterior descending coronary artery using IVUS, aiming to meet the prespecified criteria (OPTIVUS criteria: minimum stent area > distal reference lumen area [stent length ≥28mm], and minimum stent area >0.8 × average reference lumen area [stent length <28mm]) for optimal stent expansion. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCE) (death/myocardial infarction/stroke/any coronary revascularization). The predefined performance goals were derived from the CREDO-Kyoto (Coronary REvascularization Demonstrating Outcome study in Kyoto) PCI/CABG registry cohort-2 fulfilling the inclusion criteria in this study. RESULTS: In this study, 40.1% of the patients met OPTIVUS criteria in all stented lesions. The cumulative 1-year incidence of the primary endpoint was 10.3% (95% CI: 8.4%-12.2%), which was significantly lower than the predefined PCI performance goal of 27.5% (P < 0.001), and which was numerically lower than the predefined CABG performance goal of 13.8%. The cumulative 1-year incidence of the primary endpoint was not significantly different regardless of meeting or not meeting OPTIVUS criteria. CONCLUSIONS: Contemporary PCI practice conducted in the OPTIVUS-Complex PCI study multivessel cohort was associated with a significantly lower MACCE rate than the predefined PCI performance goal, and with a numerically lower MACCE rate than the predefined CABG performance goal at 1 year.2023年04月, JACC. Asia, 3(2) (2), 211 - 225, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Evidence of prognostic factors for stent failure after drug-eluting stent implantation for calcified nodules (CNs) is limited. AIMS: We aimed to clarify the prognostic risk factors associated with stent failure among patients who underwent drug-eluting stent implantation for CN lesions using optical coherence tomography (OCT). METHODS: This retrospective, multicentre, observational study included 108 consecutive patients with CNs who underwent OCT-guided percutaneous coronary intervention (PCI). To evaluate the quality of CNs, we measured their signal intensity and analysed the degree of signal attenuation. All CN lesions were divided into dark or bright CNs according to the half width of signal attenuation, greater or lower than 332, respectively. RESULTS: During the median follow-up period of 523 days, 25 patients (23.1%) experienced target lesion revascularisation (TLR). The 5-year cumulative incidence of TLR was 32.6%. Multivariable Cox regression analysis revealed that younger age, haemodialysis, eruptive CNs, dark CNs assessed by pre-PCI OCT, disrupted fibrous tissue protrusions, and irregular protrusions assessed by post-PCI OCT were independently associated with TLR. The prevalence of in-stent CNs (IS-CNs) observed at follow-up OCT was significantly higher in the TLR group than in the non-TLR group. CONCLUSIONS: Factors such as younger age, haemodialysis, eruptive CNs, dark CNs, disrupted fibrous tissue, or irregular protrusions were independently related to TLR in patients with CNs. The high prevalence of IS-CNs might indicate that the main cause of stent failure implanted in CN lesions could be the recurrence of CN progression in the stented segment.2023年03月, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本循環器学会, 2023年03月, 日本循環器学会学術集会抄録集, 87回, PJ094 - 4, 英語Diagnostic Accuracy of Nitroglycerin-free FFRCT-based Physiological Assessment in Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement(タイトル和訳中)
- 2023年02月, Circulation journal : official journal of the Japanese Circulation Society, 英語, 国内誌研究論文（学術雑誌）
- Springer Science and Business Media LLC, 2023年01月, Heart and Vessels, 38(5) (5), 634 - 644研究論文（学術雑誌）
- 2023年, Journal of cardiovascular computed tomography, 17(5) (5), 367 - 369, 英語, 国際誌
- Background Coronary artery disease (CAD) patterns play an essential role in the decision-making process about revascularization. The pullback pressure gradient (PPG) quantifies CAD patterns as either focal or diffuse based on fractional flow reserve (FFR) pullbacks. The objective of this study was to evaluate the impact of CAD patterns on acute percutaneous coronary intervention (PCI) results considered surrogates of clinical outcomes. Methods and Results This was a prospective, multicenter study of patients with hemodynamically significant CAD undergoing PCI. Motorized FFR pullbacks and optical coherence tomography (OCT) were performed before and after PCI. Post-PCI FFR >0.90 was considered an optimal result. Focal disease was defined as PPG >0.73 (highest PPG tertile). Overall, 113 patients (116 vessels) were included. Patients with focal disease were younger than those with diffuse CAD (61.4±9.9 versus 65.1±8.7 years, P=0.042). PCI in vessels with high PPG (focal CAD) resulted in higher post-PCI FFR (0.91±0.07 in the focal group versus 0.86±0.05 in the diffuse group, P<0.001) and larger minimal stent area (6.3±2.3 mm2 in focal versus 5.3±1.8 mm2 in diffuse CAD, P=0.015) compared withvessels with low PPG (diffuse CAD). The PPG was associated with the change in FFR after PCI (R2=0.51, P<0.001). The PPG significantly improved the capacity to predict optimal PCI results compared with an angiographic assessment of CAD patterns (area under the curvePPG 0.81 [95% CI, 0.73-0.88] versus area under the curveangio 0.51 [95% CI, 0.42-0.60]; P<0.001). Conclusions PCI in vessels with focal disease defined by the PPG resulted in greater improvement in epicardial conductance and larger minimal stent area compared with diffuse disease. PPG, but not angiographically defined CAD patterns, distinguished patients attaining superior procedural outcomes. Registration URL: https://clinicaltrials.gov/ct2/show/NCT03782688.2022年11月, Journal of the American Heart Association, e026960, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: The vessel healing process after implantation of biodegradable polymer (BP) and durable polymer (DP) everolimus-eluting stent (EES) in ST-elevation myocardial infarction (STEMI) lesions remains unclear.Methods and Results: We conducted a multicenter prospective randomized controlled trial to compare early (2 weeks) and mid-term (12 months) vascular responses after implantation of BP-EES vs. DP-EES in STEMI patients. In this prespecified subanalysis, serial coronary angioscopy (CAS) analysis was performed in 15 stents in the BP-EES arm (n=10 patients) and 14 stents in the DP-EES arm (n=10 patients). At the 2-week follow-up, there was no significant difference in the estimated marginal means of the neointimal coverage grade (primary endpoint) between the 2 arms (mean [±SE] 0.00±0.00 in both arms; P>0.999). There were no significant differences between the BP-EES and DP-EES groups in the yellow color grade (1.046±0.106 vs. 0.844±0.114, respectively; P=0.201) or the presence of thrombus (77.8% vs. 88.8%, respectively; P=0.205). At 12 months, competent strut coverage, defined as yellow color grade ≤1, no thrombus, and a neointimal coverage grade ≥1 was achieved more frequently in the BP-EES than DP-EES arm (85.2% vs. 53.1%; adjusted odds ratio 2.11 [95% confidence interval 1.26-3.53]; P=0.023). CONCLUSIONS: Neointimal coverage 2 weeks after implantation of BP-EES and DP-EES in STEMI lesions was comparable on CAS evaluation. However, at 1 year, BP-EES was independently associated with competent strut coverage.2022年11月, Circulation journal : official journal of the Japanese Circulation Society, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Optical coherence tomography-derived fractional flow reserve (OCT-FFR) correlates strongly with wire-based FFR; however, its clinical significance remains uncertain. OBJECTIVES: This study sought to investigate the relationship between post-percutaneous coronary intervention (PCI) OCT-FFR and long-term clinical outcomes in acute coronary syndrome (ACS). METHODS: This retrospective, multicenter, observational cohort study included consecutive patients with ACS who underwent OCT-guided emergency PCI. We analyzed post-PCI OCT images and calculated OCT-FFR to identify independent factors associated with target vessel failure (TVF) after PCI. RESULTS: Among 364 enrolled patients, 54 experienced TVF during a median follow-up of 36 (IQR: 26-48) months. Vessel-level OCT-FFR was significantly lower in the TVF group than in the non-TVF group (0.87 vs 0.94; P < 0.001). In the multivariable Cox regression analysis, low vessel-level OCT-FFR (HR per 0.1 increase: 0.38; 95% CI: 0.29-0.49; P < 0.001) and thin-cap fibroatheroma in the nonculprit lesion were independently associated with TVF. The TVF rate of vessels with both low vessel-level OCT-FFR (<0.90) and thin-cap fibroatheroma in the nonculprit lesion was 8.1 times higher than that of all other vessels (69.3% vs 12.4%; HR: 8.13; 95% CI: 4.33-15.25; log-rank P < 0.001). Furthermore, adding vessel-level OCT-FFR to baseline characteristics and post-PCI OCT findings improved discriminatory and reclassification ability in identifying patients with subsequent TVF. CONCLUSIONS: Vessel-level OCT-FFR was an independent factor associated with TVF after PCI in patients with ACS. Adding the OCT-FFR measurement to post-PCI OCT findings may enable better discrimination of patients with subsequent TVF after PCI for ACS. (Relationship between Intracoronary Optical Coherence Tomography Derived Virtual Fractional Flow Reserve and cardiovascular outcome on Acute coronary syndrome; UMIN000043858).2022年10月, JACC. Cardiovascular interventions, 15(20) (20), 2035 - 2048, 英語, 国際誌研究論文（学術雑誌）
- Elsevier BV, 2022年09月, Journal of the American College of Cardiology, 80(12) (12), B109 - B110研究論文（学術雑誌）
- Elsevier BV, 2022年09月, Journal of the American College of Cardiology, 80(12) (12), B111 - B112研究論文（学術雑誌）
- The early and mid-term arterial healing profile of biodegradable polymer-coated everolimus-eluting stents (BP-EES) is unclear, especially in ST-segment elevation myocardial infarction (STEMI) culprit lesions. This study aimed to compare early- and mid-term arterial healing between durable polymer-coated everolimus-eluting stents (DP-EES) and BP-EES in STEMI patients. In a prospective, multicenter, non-inferiority trial, STEMI patients were randomized to receive BP-EES (n = 60) or DP-EES (n = 60). The primary endpoint of this study was the mean percentage of covered struts (%covered struts) on FD-OCT 2 weeks post-PCI. Key secondary endpoints included the percentage of uncovered struts, frequency of abnormal intra-stent tissue, and percentage of malapposed struts by FD-OCT 2 weeks and 12 months post-PCI. They underwent serial frequency-domain optical coherence tomography (FD-OCT) evaluations immediately after percutaneous coronary intervention, and at 2 weeks and at 12 months after the procedure. The primary endpoint of %covered struts at 2 weeks was 71.4% in BP-EES and 72.3% in DP-EES [risk difference - 0.94%, lower limit of one-sided 95% confidence interval (CI) - 5.6; Pnon-inferiority = 0.0756]. At 12 months, the mean percentage of uncovered struts was significantly lower [1.73% (95% CI 0.28-3.17) vs. 4.81% (95% CI 3.52-6.09); p = 0.002], and the average malapposed volume was significantly smaller in the BP-EES group than in the DP-EES group (p = 0.002). At 12 months, BP-EES had a significantly larger average neointimal area with a significantly smaller average intra-stent tissue unevenness score than DP-EES, suggesting more uniform neointimal coverage with BP-EES. Strut coverage was comparable between BP-EES and DP-EES at 2 weeks. Non-inferiority could not be proven because of an insufficient sample size. The significantly better arterial healing with BP-EES at 12 months suggests a safer profile for STEMI culprit lesions.Trial registration: jRCTs022180024 https://jrct.niph.go.jp/en-latest-detail/jRCTs022180024.2022年07月, Cardiovascular intervention and therapeutics, 38(1) (1), 75 - 85, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Low fractional flow reserve (FFR) values after percutaneous coronary intervention (PCI) carry a worse prognosis than high post-PCI FFR values. Therefore, the ability to predict post-PCI FFR might play an important role in procedural planning. Post-PCI FFR values can now be computed from pre-PCI coronary computed tomography angiography (CTA) using the fractional flow reserve derived from coronary computed tomography angiography revascularization planner (FFRCT Planner). OBJECTIVES: The aim of this study was to validate the accuracy of the FFRCT Planner. METHODS: In this multicenter, investigator-initiated, prospective study, patients with chronic coronary syndromes and significant lesions based on invasive FFR ≤0.80 were recruited. The FFRCT Planner was applied to the fractional flow reserve derived from coronary computed tomography angiography (FFRCT) model, simulating PCI. The primary objective was the agreement between the predicted post-PCI FFR by the FFRCT Planner and measured post-PCI FFR. Accuracy of the FFRCT Planner's luminal dimensions was assessed by using post-PCI optical coherence tomography as the reference. RESULTS: Overall, 259 patients were screened, with 120 patients (123 vessels) included in the final analysis. The mean patient age was 64 ± 9 years, and 24% had diabetes. Measured FFR post-PCI was 0.88 ± 0.06, and the FFRCT Planner FFR was 0.86 ± 0.06 (mean difference: 0.02 ± 0.07 FFR unit; limits of agreement: -0.12 to 0.15). Optical coherence tomography minimal stent area was 5.60 ± 2.01 mm2, and FFRCT Planner minimal stent area was 5.0 ± 2.2 mm2 (mean difference: 0.66 ± 1.21 mm2; limits of agreement: -1.7 to 3.0). The accuracy and precision of the FFRCT Planner remained high in cases with focal and diffuse disease and with low and high calcium burden. CONCLUSIONS: The FFRCT-based technology was accurate and precise for predicting FFR after PCI. (Precise Percutaneous Coronary Intervention Plan Study [P3]; NCT03782688).2022年07月, JACC. Cardiovascular imaging, 15(7) (7), 1242 - 1255, 英語, 国際誌研究論文（学術雑誌）
- Percutaneous transluminal septal myocardial ablation (PTSMA) is a well-established interventional therapy for drug-refractory hypertrophic obstructive cardiomyopathy (HOCM) as an alternative to surgical myectomy. Although guidelines recommend that PTSMA should be performed in institutions with extensive experience, it is not centralized to such high-volume centers in real-world clinical practice. Thus, this study aimed to assess the feasibility of PTSMA in non-high-volume centers. We retrospectively examined patients with HOCM who underwent PTSMA between August 2012 and May 2020 at four institutions that experienced fewer than 20 cases of PTSMA procedures. The primary clinical endpoint was a composite of safety (all-cause death, electrical defibrillation for ventricular tachycardia or fibrillation, cardiac tamponade, permanent pacemaker implantation, and repeated interventions) and efficacy endpoints (repeated interventions [PTSMA or surgical myectomy]). Fifty-eight consecutive patients were enrolled. During the 30-day follow-up, no major clinical adverse events were noted except three patients (5.2%) requiring permanent pacemaker implantation for complete atrioventricular block. The percentage of patients with New York Heart Association functional class 1 or 2 significantly increased from 8.6 to 100% (p < 0.001). In the Cox proportional hazard model, left ventricular outflow tract pressure gradient at rest ≥ 30 mmHg (hazard ratio [HR] 6.56; 95% confidence interval [CI] 1.44-29.90; p = 0.015) and mitral regurgitation grade ≥ 3 (HR 10.75; 95% CI 1.81-63.79; p = 0.009) at the 30-day follow-up were associated with a composite of major clinical adverse events. The current study demonstrated that 58 patients who underwent PTSMA in non-high-volume centers had favorable 30-day clinical outcomes, with a primary composite endpoint rate of 5.2%. A prospective study with a larger sample size and longer follow-up is warranted to verify the safety and efficacy of PTSMA in non-high-volume centers.2022年05月, Heart and vessels, 英語, 国内誌研究論文（学術雑誌）
- 2022年05月, Circulation, 145(18) (18), 1434 - 1436, 英語, 国際誌
- In this updated expert consensus document, the methods for the quantitative measurement and morphological assessment of optical coherence tomography (OCT)/optical frequency domain imaging images (OFDI) are briefly summarized. The focus is on the clinical application and the clinical evidence of OCT/OFDI to guide percutaneous coronary interventions.2022年04月, Cardiovascular intervention and therapeutics, 37(2) (2), 248 - 254, 英語, 国内誌研究論文（学術雑誌）
- OBJECTIVE: We investigated the effect of proximal optimization technique (POT) on coronary bifurcation stent failure (BSF) in cross-over stenting by comparing with the kissing balloon technique (KBT) in a multicenter randomized PROPOT trial. BACKGROUND: POT is recommended due to increased certainty for optimal stent expansion and side branch (SB) wiring. METHODS: We randomized 120 patients treated with crossover stenting into the POT group, which was followed by SB dilation (SBD), and the KBT group. Finally, 52 and 57 patients were analyzed by optical coherence tomography before SBD and at the final procedure, respectively. Composite BSF was defined as a maximal malapposition distance of >400 μm, or malapposed and SB-jailed strut rates of >5.95% and >21.4%, respectively. RESULTS: Composite BSF before SBD in the POT and KBT groups was observed in 29% and 26% of patients, respectively. In the POT group, differences in stent volumetric index between the proximal and distal bifurcation (odds ratio [OR] 60.35, 95% confidential interval [CI] 0.13-0.93, p = 0.036) and between the proximal bifurcation and bifurcation core (OR: 3.68, 95% CI: 1.01-13.40, p = 0.048) were identified as independent risk factors. Composite BSF at final in 27% and 32%, and unplanned additional procedures in 38% and 25% were observed, respectively. Composite BSF before SBD was a risk factor for the former (OR: 6.33, 95% CI: 1.10-36.50, p = 0.039) and the latter (OR: 6.43, 95% CI: 1.25-33.10, p = 0.026) in the POT group. CONCLUSION: POT did not result in a favorable trend in BSF. Insufficient expansion of the bifurcation core after POT was associated with BSF.2022年03月, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 99(4) (4), 1047 - 1058, 英語, 国際誌研究論文（学術雑誌）
- Objective Previous studies have described several prognostic factors for heart failure (HF); however, these results were derived from registries consisting of conventional age groups, which might not represent the increasingly aging society. The present study explored the prognostic factors for all-cause death in hospitalized patients with HF across different age categories using an acute HF registry that included relatively old patients. Methods From a total of 1,971 consecutive patients with HF, 1,136 patients were enrolled. We divided the patients into 4 groups (≤65, 66-75, 76-85, and >85 years old) to evaluate all-cause death and prognostic factors of all-cause death. Results During the mean follow-up period of 1,038 days, 445 patients (39.2%) had all-cause death. A Kaplan-Meier analysis demonstrated significantly higher incidence of all-cause death in the elderly groups than in the younger groups (log-rank p<0.001). A Cox proportional-hazard regression analysis revealed that the presence of atrial fibrillation [hazard ratio (HR): 23.3, 95% confidence interval (CI): 2.36-231.1, p=0.007] was a notable predictive factor for all-cause death in the ≤65 years old group, whereas the Clinical Frailty Scale score (HR: 1.33, 95% CI: 1.16-1.52, p<0.001) and hypoalbuminemia (HR: 0.49, 95% CI: 0.31-0.78, p=0.003) were predictors in the >85 years old group. Conclusions Atrial fibrillation was a notable predictor of HF in young patients, whereas frailty and low-grade albuminemia were essential predictive factors of HF in elderly patients. With the increasing number of elderly patients with HF, comprehensive multidisciplinary treatment will be necessary.2022年, Internal medicine (Tokyo, Japan), 61(21) (21), 3171 - 3180, 英語, 国内誌研究論文（学術雑誌）
- The initial process of atherosclerotic development has not been systematically evaluated. This study aimed to observe atherosclerotic progression from normal vessel wall (NVW) to atherosclerotic plaque and examine local factors associated with such progression using > 5-year long-term follow-up data obtained by serial optical coherence tomography (OCT). A total of 49 patients who underwent serial OCT for lesions with NVW over 5 years (average: 6.9 years) were enrolled. NVW was defined as a vessel wall with an OCT-detectable three-layer structure and intimal thickness ≤ 300 μm. Baseline and follow-up OCT images were matched, and OCT cross sections with NVW > 30° were enrolled. Cross sections were diagnosed as "progression" when the NVW in these cross sections was reduced by > 30° at > 5-year follow-up. Atherogenic progression from NVW to atherosclerotic plaque was observed in 40.8% of enrolled cross sections. The incidence of microchannels in an adjacent atherosclerotic plaque within the same cross section (6.7 vs. 3.3%; p = 0.046) and eccentric distribution of atherosclerotic plaque (25.0 vs. 12.6%; p < 0.001) at baseline was significantly higher in cross sections with progression than in those without. Cross sections with progression exhibited significantly higher NVW intimal thickness at baseline than cross sections without progression (200.1 ± 53.7 vs. 180.2 ± 59.6 μm; p < 0.001). Multivariate analysis revealed that the presence of microchannels in an adjacent atherosclerotic plaque, eccentric distribution of atherosclerotic plaque, and greater NVW intimal thickness at baseline were independently associated with progression at follow-up. The presence of microchannels in an adjacent atherosclerotic plaque, eccentric distribution of atherosclerotic plaque, and greater NVW intimal thickness were potentially associated with initial atherosclerotic development from NVW to atherosclerotic plaque.2022年01月, Heart and vessels, 37(1) (1), 1 - 11, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: The impact of the extent of aortic atheroma on patients' prognosis after transcatheter aortic valve replacement (TAVR) has not been completely evaluated. This study aimed to evaluate the prognostic value of the aortic atheroma volume (AAV) derived from computed tomography, and the effect of its differences among the segments of the aorta, in patients undergoing TAVR. METHODS: In total, 143 patients with symptomatic severe aortic stenosis who underwent pre-procedural computed tomography before TAVR procedure indication were evaluated. AAV was calculated by measuring the aortic lumen and vessel volume using every 1-mm axial image and was further divided into thoracic (TAAV) and abdominal segments (AbAAV). RESULTS: During a median follow-up of 651 days, 24 all-cause and 14 cardiac deaths occurred. In the Kaplan-Meier analysis, the high AAV group had significantly higher all-cause and cardiac mortalities than the low AAV group (p = 0.016 and 0.023, respectively). Regarding segmental AAV, all-cause and cardiac mortalities did not have significant differences between the high and low TAAV groups. Moreover, all-cause and cardiac mortalities were significantly higher in the high AbAAV group than in the low AbAAV group (p = 0.0043 and 0.023, respectively). The multivariable analysis showed that only AbAAV was an independent predictor for all-cause mortality (hazard ratio: 1.06, p = 0.046). CONCLUSION: AAV was significantly associated with the mortality after TAVR. The current study suggests the pre-procedural assessment of AAV is valuable in predicting prognosis after TAVR. However, further investigation with a larger sample size is needed to validate our findings.2021年12月, International journal of cardiology, 344, 60 - 65, 英語, 国際誌研究論文（学術雑誌）
- John Wiley and Sons Inc, 2021年11月, Catheterization and Cardiovascular Interventions, 98(5) (5), E715 - E723, 英語研究論文（学術雑誌）
- 2021年10月, Circulation journal : official journal of the Japanese Circulation Society, 85(11) (11), 2029 - 2031, 英語, 国内誌
- Background Myocardial extracellular volume fraction (ECV), measured by cardiac magnetic resonance imaging, is a useful prognostic marker for patients who have undergone aortic valve replacement (AVR) for aortic stenosis. However, the prognostic significance of ECV measurements based on computed tomography (CT) is unclear. This study evaluated the association between ECV measured with dual-energy CT and clinical outcomes in patients with aortic stenosis who underwent transcatheter or surgical AVR. Methods and Results We retrospectively enrolled 95 consecutive patients (age, 84.0±5.0 years; 75% women) with severe aortic stenosis who underwent preprocedural CT for transcatheter AVR planning. ECV was measured using iodine density images obtained by delayed enhancement dual-energy CT. The primary end point was a composite outcome of all-cause death and hospitalization for heart failure after AVR. The mean ECV measured with CT was 28.1±3.8%. During a median follow-up of 2.6 years, 22 composite outcomes were observed, including 15 all-cause deaths and 11 hospitalizations for heart failure. In Kaplan-Meier analysis, the high ECV group (≥27.8% [median value]) had significantly higher rates of composite outcomes than the low ECV group (<27.8%) (log-rank test, P=0.012). ECV was the only independent predictor of adverse outcomes on multivariable Cox regression analysis (hazards ratio, 1.25; 95% CI, 1.10‒1.41; P<0.001). Conclusions Myocardial ECV measured with dual-energy CT in patients who underwent aortic valve intervention was an independent predictor of adverse outcomes after AVR.2021年09月, Journal of the American Heart Association, 10(18) (18), e020655, 英語, 国際誌研究論文（学術雑誌）
- Background: The effect of intraindividual variability in lipid levels on the onset of acute coronary syndrome (ACS) remains uncertain. We evaluated the relationship between intraindividual variability in lipid levels and culprit lesion morphologies by optical coherence tomography (OCT). Methods and Results: Seventy-four consecutive patients with ACS whose cholesterol levels were assessed ≥3 times during outpatient visits before the onset of ACS were enrolled in the study; 222 patients without significant stenotic lesions were used as a control group. Based on OCT findings of culprit lesions, ACS patients were categorized into a plaque rupture ACS (PR-ACS) group (n=44) or a non-plaque rupture ACS (NPR-ACS) group (erosion or calcified nodule; n=30). Visit-to-visit variability in lipid levels was evaluated using the corrected variability independent of the mean (cVIM). Patients with ACS had significantly higher low-density lipoprotein cholesterol (LDL-C) levels and cVIM in LDL-C than the control group. The PR-ACS group had significantly higher mean LDL-C levels and greater cVIM in LDL-C than the control group. The PR-ACS group had a significantly higher cVIM than the NPR-ACS group, despite similar mean LDL-C levels. Multivariate analysis revealed that higher cVIM of LDL-C was an independent predictor of PR-ACS (odds ratio 1.06; P=0.018). Conclusions: In addition to the LDL-C level, greater visit-to-visit variability in LDL-C levels may be associated with the onset of ACS induced by plaque rupture.2021年09月, Circulation reports, 3(9) (9), 540 - 549, 英語, 国内誌研究論文（学術雑誌）
- Background Although patients with a cancer history have a 2 to 3 times higher risk for acute coronary syndrome (ACS), the morphological characteristics of ACS culprit plaque in those patients and their relations with clinical outcomes remain unknown. Methods and Results This retrospective, multicenter, observational cohort study included consecutive patients with ACS who underwent optical coherence tomography-guided emergent percutaneous coronary intervention. Patients were categorized into those without a cancer history, those with a cancer history, and those currently receiving cancer treatment. ACS culprit lesions were classified as plaque rupture, plaque erosion, or calcified nodule using optical coherence tomography. Plaque erosion frequency was significantly higher in culprit lesions of patients with current cancer and patients with cancer history than in those of patients without cancer history (56.3% versus 61.7% versus 36.5%). Calcified nodule incidence was significantly higher in patients without cancer history than in patients with current cancer and patients without cancer history (patients with current cancer: 12.4% versus patients without cancer history: 25.5% versus patients without cancer history: 12.6%, P<0.001). Cancer history was independently associated with nonplaque rupture (plaque erosion or calcified nodule) in ACS culprit lesions (odds ratio, 4.00; P<0.001). Cancer history was independently associated with major adverse cardiovascular events (hazard ratio [HR], 1.98; P=0.002). Nonplaque rupture in ACS culprit lesions was independently associated with major adverse cardiovascular events (HR, 1.60; P=0.011). Conclusions Patients with a cancer history had significantly worse clinical outcomes after ACS than those without a cancer history. Those with a cancer history had significantly higher plaque erosion and calcified nodule incidences in the ACS culprit lesions, which might partly explain their worse clinical outcomes. Registration URL: www.umin.ac.jp/ctr/index.htm. Unique Identifier: UMIN000038442.2021年08月, Journal of the American Heart Association, 10(15) (15), e020243, 英語, 国際誌研究論文（学術雑誌）
- 2021年06月, Cardiovascular intervention and therapeutics, 英語, 国内誌研究論文（学術雑誌）
- AIMS/INTRODUCTION: Glucose fluctuation (GF) is a residual risk factor for coronary artery disease (CAD). We investigated whether GF influenced clinical outcomes and progression of coronary stenosis in stable CAD patients. MATERIALS AND METHODS: In this prospective study, 101 consecutive lipid-controlled stable CAD patients underwent percutaneous coronary intervention were enrolled, and GF was expressed as the mean amplitude of glycemic excursion (MAGE) obtained by continuous glucose monitoring before the procedure was evaluated. At 9 months after enrollment, culprit and non-culprit (mild-to-moderate stenosis without ischemia) lesions were serially assessed by angiography. Cardiovascular events (CVE) consisting of cardiovascular death, non-fatal myocardial infarction or ischemia-driven revascularization during 2-year follow up, rapid progression in non-culprit lesions (defined as ≥10% luminal narrowing progression in lesions with stenosis ≥50%, ≥30% luminal narrowing progression in non-culprit lesions with stenosis <50% or normal segment, or progression to total occlusion) were evaluated. RESULTS: CVE occurred in 25 patients, and MAGE was significantly higher in the CVE group (76.1 ± 24.8 mg/dL vs 59.3 ± 23.7 mg/dL; P = 0.003). Multivariate analysis showed that MAGE was an independent predictor of CVE (odds ratio 1.027, 95% confidence interval 1.008-1.047; P = 0.005). The optimal MAGE value to predict CVE was 70.7 mg/dL (area under the curve 0.687, 95% confidence interval 0.572-0.802; P = 0.005). Furthermore, MAGE was independently associated with rapid progression, and with the luminal narrowing progression in all non-culprit lesions (r = 0.400, P < 0.05). CONCLUSIONS: Daily GF might influence future CVE in lipid-controlled stable CAD patients.2021年06月, Journal of diabetes investigation, 12(6) (6), 1015 - 1024, 英語, 国内誌研究論文（学術雑誌）
- Optical frequency domain imaging (OFDI) is a high-resolution intracoronary imaging modality with fast automated longitudinal pullback. We aimed to evaluate the ability of performing OFDI from the superficial femoral artery (SFA) to the below-knee (BK) artery. This clinical trial was a multi-center, single-arm, open-label study. The primary endpoint was to obtain a clear image of the intra-vascular lumen from the SFA to the BK artery, specifically > 270° visualization of the blood vessel lumen with > 16/21 cross sections. The proportion of the clear image (≥ 85%) was regarded as confirmatory of the ability of OFDI to visualize the vessel lumen. Overall, 20 patients were enrolled. The proportion of the primary endpoint was 90% (18/20), and the pre-specified criterion was successfully attained. The proportion of the clear image assessed by the operator was 100% (20/20), and an additional statistical analysis for the proportion of the visualization, > 270°, of the blood vessel lumen revealed a significantly higher cut-off value than that for the pre-specified criterion, 85% (p = 0.0315). There were three adverse events not related to OFDI. OFDI achieved acceptable visualization of the vessel lumen without any adverse event related to it. After regulatory approval based on the present study, OFDI will be available as a new option of endovascular imaging for peripheral artery diseases in daily practiceTrial registration: This study was registered in the Japanese Registry of Clinical Trials (jRCT 2052190025, https://jrct.niph.go.jp/latest-detail/jRCT2052190025 ).2021年06月, Heart and vessels, 36(6) (6), 818 - 826, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: The impact of antiplatelet drug effects on mid-term local arterial responses following percutaneous coronary intervention (PCI) remains uncertain. We evaluated the impact of the platelet reactivity of prasugrel on mid-term vascular healing between acute coronary syndrome (ACS) and stable coronary artery disease (CAD).Methods and Results:We conducted a prospective, 12-center study in 125 patients with ACS and 126 patients with stable CAD who underwent PCI with an everolimus-eluting stent (EES) and received dual antiplatelet therapy (DAPT) with prasugrel and aspirin. Serial optical coherence tomography (OCT) was performed immediately after PCI and at the 9-month follow-up to assess the association of P2Y12reaction units (PRU) with the frequency of malapposed or uncovered struts and intrastent thrombi (IST). The incidence of abnormal mid-term OCT findings did not different between the ACS and CAD arms, regardless of clinical presentation, except that uncovered struts were more frequent in the ACS than CAD arm. PRU at PCI was significantly associated with the frequency of IST at follow-up, but not with uncovered and malapposed struts. PRU at PCI was the only independent predictor of IST detected at follow-up (odds ratio 1.009). CONCLUSIONS: In patients undergoing EES implantation and receiving prasugrel, achieving an adequate antiplatelet effect at the time of stent implantation may regulate thrombus formation throughout the follow-up period.2021年05月, Circulation journal : official journal of the Japanese Circulation Society, 85(6) (6), 808 - 816, 英語, 国内誌研究論文（学術雑誌）
- OBJECTIVES: The primary objective of the current analysis was to assess the association between the clinical presentation at index procedure and mortality in patients with second-generation drug-eluting stent thrombosis (G2-ST). BACKGROUND: Patients with acute coronary syndrome (ACS) have a higher risk for stent thrombosis (ST) as compared with those with chronic coronary syndrome (CCS). However, clinical outcomes of patients with G2-ST after treatment for ACS and CCS remain poorly understood. METHODS: From the REAL-ST (Retrospective Multicenter Registry of ST After First- and Second-Generation Drug-Eluting Stent Implantation) registry, this study evaluated 313 patients with G2-ST. According to baseline clinical presentation, patients were divided into the 2 groups: the ACS and CCS groups (n = 147 and n = 166, respectively). The primary endpoint was the cumulative 3-year incidence of all-cause death after the index ST events. Timing of ST, target lesion revascularization, and recurrent ST were also assessed. RESULTS: Early ST was more frequently observed in the ACS group (71.4% vs. 44.6%), while very late ST was less likely to occur in the ACS group than in the CCS group (11.6% vs. 30.7%). Cumulative 3-year incidence of all-cause death after the index ST events was comparable between the ACS and CCS groups (28.6% vs. 28.3%; hazard ratio: 1.14; 95% confidence interval: 0.75 to 1.73; p = 0.55). Compared with the CCS group, the ACS group showed higher incidences of target lesion revascularization and recurrent ST (23.8% vs. 17.2%; p = 0.06; and 9.9% vs. 1.4%; p = 0.001, respectively). CONCLUSIONS: Patients with G2-ST were associated with higher mortality irrespective of baseline clinical presentation.2021年05月, JACC. Cardiovascular interventions, 14(10) (10), 1082 - 1090, 英語, 国際誌研究論文（学術雑誌）
- PURPOSES: The closure of atrial septal defect (ASD) is associated with a significant reduction in right ventricular (RV) overload and an improvement in functional capacity in most adults with ASD. However, a subset of patients remains symptomatic even after closure due to therapeutic delay. To date, no clinically robust preoperative predictor of postoperative residual symptoms has been clearly identified. METHODS: In this study, 120 adult patients with ASD and 39 controls were investigated. As an index of RV myocardial deformation, RV global longitudinal strain (RV-GLS) was evaluated. The degree of coupling between RV and pulmonary artery (PA) was quantified by the tricuspid annular plane systolic excursion (TAPSE) divided by the PA systolic pressure (PASP). RESULTS: Compared to controls, baseline RV-GLS was significantly greater (- 27 ± 7 vs. - 23 ± 5%, P = 0.02) and TAPSE/PASP ratio was severely impaired (0.8 ± 0.3 vs. 2.1 ± 1.6 mm/mmHg, P < 0.01) in ASD patients. At 6 months after closure, 15 patients (12.5%) remained symptomatic. In patients without residual symptoms, TAPSE/PASP ratio significantly improved from 0.9 ± 0.3 to 1.0 ± 0.6 mm/mmHg (P = 0.02), and RV-GLS normalized (from - 28 ± 11 to - 24 ± 7%, P < 0.01) after closure. However, RV-GLS and TAPSE/PASP ratio showed no significant change in ASD patients with residual symptoms. On multivariate analysis, preoperative TAPSE/PASP ratio (odds ratio [OR] 0.034, 95% confidence interval [CI] 0.000-0.604, P = 0.03) and pulmonary vascular resistance index ([PVRI], OR 1.011, 95% CI 1.000-1.021, P < 0.05) were associated with the postoperative symptomatic status. CONCLUSION: In terms of integrated assessment of the RV-PA unit, preoperative TAPSE/PASP ratio and PVRI were important determinants of residual symptoms after ASD closure.2021年05月, The international journal of cardiovascular imaging, 英語, 国際誌研究論文（学術雑誌）
- Culprit lesions of acute coronary syndrome (ACS) could be classified as plaque rupture (PR), erosion, or calcified nodule (CN). We aimed to determine the relationship among clinical characteristics, morphological plaque features, and long-term prognosis in ACS. Patients with ACS, who underwent pre-intervention optical coherence tomography between April 2013 and July 2018 were retrospectively enrolled, and classified into the three groups based on the culprit lesion morphology. In the 436 patients enrolled, incidences of PR, erosion, and CN in ACS culprit lesions were 46.1, 39.9, and 14.0%, respectively. Plaque erosion was more frequent in men aged < 60 years and CN was more frequent in older adults in both sexes (≥ 80 years) (P < 0.001). Patients with CN had a higher incidence of hemodialysis treatment (P < 0.001) and diabetes (P = 0.003). Multivariate analysis revealed that ST elevation myocardial infarction (STEMI) (P = 0.049) and presence of thin-cap fibroatheroma (TCFA) at the culprit lesion were independently associated with PR; in younger patients (< 60 year), preserved left ventricular ejection fraction and lower incidence of TCFA were correlated with plaque erosion; and older age, non-STEMI, or unstable angina pectoris, higher serum brain natriuretic peptide levels, and lower incidence of TCFA were independently associated with CN. Multivariable analysis revealed that CN (odds ratio [OR] 1.990, P = 0.005), male sex (OR 2.012, P = 0.004), and older age (OR 1.036, P < 0.001) were independently associated with future adverse events during a median follow-up of 757 days. Different patient characteristics and morphological features were associated with the type of culprit lesion in patients with ACS.2021年05月, The international journal of cardiovascular imaging, 英語, 国際誌研究論文（学術雑誌）
- Background Stent thrombosis (ST) after drug-eluting stent (DES) implantation remains a life-threatening complication. Recurrent ST (RST) is not a rare phenomenon, potentially contributing to high mortality after the index ST events. However, little evidence is available about the incidence, risk factors, and clinical outcomes of definite RST after DES thrombosis. Methods and Results From REAL-ST (Retrospective Multicenter Registry of ST After First- and Second- Generation DES Implantation), this study evaluated 595 patients with definite ST (first-generation DES thrombosis, n=314; second-generation DES thrombosis, n=281). During a median follow-up of 31 months, we identified 32 patients with definite RST after first-generation DES thrombosis (n=18) and second-generation DES thrombosis (n=15). Cumulative incidence of RST was 4.5% and 6.0% at 1 and 5 years, respectively, which did not significantly differ between first-generation DES thrombosis and second-generation DES thrombosis. Independent predictors of definite RST were early ST (hazard ratio [HR], 2.38; 95% CI, 1.06-5.35 [P=0.035]) and multivessel ST (HR, 3.47; 95% CI, 1.03-11.7 [P=0.044]). Definite RST was associated with a 2.8-fold increased risk of mortality (adjusted HR, 2.78; 95% CI, 1.35-5.73 [P=0.006]). Conclusions Cumulative incidence of definite RST did not significantly differ between first-generation DES thrombosis and second-generation DES thrombosis. Early ST and multivessel ST were risk factors of definite RST. Definite RST significantly increased mortality after DES thrombosis, highlighting the clinical importance of preventing RST to improve outcomes of patients with ST. Registration URL: https://www.clinicaltrials.gov; Unique identifier: UMIN000025181.2021年05月, Journal of the American Heart Association, 10(9) (9), e018972, 英語, 国際誌研究論文（学術雑誌）
- The purpose of this study was to assess early and late vascular healing in response to bioresorbable-polymer sirolimus-eluting stents (BP-SESs) for the treatment of patients with ST-elevation myocardial infarction (STEMI) and stable coronary artery disease (CAD). A total of 106 patients with STEMI and 101 patients with stable-CAD were enrolled. Optical frequency-domain images were acquired at baseline, at 1- or 3-month follow-up, and at 12-month follow-up. In the STEMI and CAD cohorts, the percentage of uncovered struts (%US) was significantly and remarkably decreased during early two points and at 12-month (the STEMI cohort: 1-month: 18.75 ± 0.78%, 3-month: 10.19 ± 0.77%, 12-month: 1.80 ± 0.72%; p < 0.001, the CAD cohort: 1-month: 9.44 ± 0.78%, 3-month: 7.78 ± 0.78%, 12-month: 1.07 ± 0.73%; p < 0.001 respectively). The average peri-strut low-intensity area (PLIA) score in the STEMI cohort was significantly decreased during follow-up period (1.90 ± 1.14, 1.18 ± 1.25, and 1.01 ± 0.72; p ≤ 0.001), whereas the one in the CAD cohort was not significantly changed (0.89 ± 1.24, 0.67 ± 1.07, and 0.64 ± 0.72; p = 0.59). In comparison with both groups, differences of %US and PLIA score at early two points were almost disappeared or close at 12 months. The strut-coverage and healing processes in the early phase after BP-SES implantation were significantly improved in both cohorts, especially markedly in STEMI patients. At 1 year, qualitatively and quantitatively consistent neointimal coverage was achieved in both pathogenetic groups.2021年04月, Cardiovascular intervention and therapeutics, 37(2) (2), 281 - 292, 英語, 国内誌研究論文（学術雑誌）
- Whether predicting the rotational atherectomy (RA) effect based on the position of optical frequency domain imaging (OFDI) is accurate remains uncertain. The aim of this study was to evaluate the predictive accuracy of OFDI in identifying RA location and area. Twenty-five patients who underwent RA with OFDI were included. On pre-RA OFDI images, a circle with the dimension of a Rota burr was drawn at the center of the OFDI catheter. The area where the circle overlapped with the vessel wall was defined as the predicted ablation area (P-area), and the actual ablated area (A-area) was measured. The predictive accuracy of OFDI was evaluated as follows: overlapped ablation area (O-area: overlapping P- and A-areas) divided by P-area = %Correct-area, and A-area - O-area divided by A-area = %Error-area. Cross-sections were separated into four categories based on the median values of %Correct- and %Error-area. Among 334 cross-sections, RA effects were confirmed in the predicted location in 87% of them. The median %Correct- and %Error-areas were 43.1% and 64.2%, respectively. Floppy wire, narrow lumen area, OFDI catheter close to the intima, and large arc of calcium were independently associated with good prediction (high %Correct-/low %Error-areas). Non-left anterior descending lesions, OFDI catheter far from the wire, and OFDI catheter and wire far from the intima were associated with irrelevant ablation (low %Correct-/ high %Error-areas). The accuracy of the OFDI-based predictions for RA effects was acceptable with regard to location, but not high with regard to area. Wire types, target vessels, and OFDI catheter and wire positions are important determinants for accurately predicting RA effect using pre-procedural OFDI.2021年04月, Heart and vessels, 英語, 国内誌研究論文（学術雑誌）
- To investigate the feasibility of pre-procedural morphological assessment of coronary artery calcification in severely calcified lesions with electrocardiography (ECG)-gated non-contrast computed tomography (CT). Severely calcified coronary arteries in patients who underwent ECG-gated non-contrast CT prior to optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) were studied retrospectively. CT and OCT data were co-registered by marking landmark structures such as side branches and reviewed side by side with cross-sectional images. The maximum calcium angle (MCA) and presence of nodular calcification (NC) were evaluated. A total of 496 cross-sections in 16 lesions were included in this analysis. The Pearson correlation coefficient between CT- and OCT-derived MCA was 0.92 (p < 0.001). Bland-Altman plots of OCT-derived MCA in relation to CT-derived MCA showed a mean bias of 4.8 degrees with 95% limits of agreement of - 69.7 to 79.4 degrees. Sensitivity, specificity, and positive and negative predictive values of CT in identifying MCA > 270 degrees were 90.3%, 79.7%, 92.1%, and 97.4%, respectively. Sensitivity, specificity, and positive and negative predictive values of CT in identifying NC were 73.3%, 97.5%, 47.8%, and 99.2%, respectively. ECG-gated non-contrast coronary CT might be helpful to obtain detailed information of severe coronary artery calcification before PCI.2021年04月, The international journal of cardiovascular imaging, 37(4) (4), 1445 - 1453, 英語, 国際誌研究論文（学術雑誌）
- Over the past 40 years, the safety and efficacy of percutaneous coronary intervention has dramatically improved by overcoming several challenges. The introduction of drug-eluting stent (DES) in particular was a major breakthrough in interventional cardiology. Compared to bare-metal stents, first-generation DES (G1-DES) has dramatically reduced the rates of in-stent restenosis and subsequent target lesion revascularization. However, major safety concerns surrounding stent thrombosis (ST) emerged with G1-DES in clinical practice as a result of the high incidences of death, myocardial infarction, and repeat revascularization associated with ST. To overcome these limitations, second-generation DES (G2-DES) has been developed with an improved stent platform with thinner strut and biocompatible durable or biodegradable polymers. Indeed, G2-DES, when compared with G1-DES, has improved clinical outcomes by reducing the risk of late thrombotic events while maintaining anti-restenotic efficacy, whereas ST still occurs, even with the use of G2-DES. This review gives an overview of pathophysiology, risk factors, and outcomes of ST after DES implantation. Additionally, we discuss the management and prevention of ST.2021年04月, Cardiovascular intervention and therapeutics, 36(2) (2), 158 - 168, 英語, 国内誌研究論文（学術雑誌）
- INTRODUCTION: Fractional flow reserve (FFR) measured after percutaneous coronary intervention (PCI) has been identified as a surrogate marker for vessel related adverse events. FFR can be derived from standard coronary computed tomography angiography (CTA). Moreover, the FFR derived from coronary CTA (FFRCT ) Planner is a tool that simulates PCI providing modeled FFRCT values after stenosis opening. AIM: To validate the accuracy of the FFRCT Planner in predicting FFR after PCI with invasive FFR as a reference standard. METHODS: Prospective, international and multicenter study of patients with chronic coronary syndromes undergoing PCI. Patients will undergo coronary CTA with FFRCT prior to PCI. Combined morphological and functional evaluations with motorized FFR hyperemic pullbacks, and optical coherence tomography (OCT) will be performed before and after PCI. The FFRCT Planner will be applied by an independent core laboratory blinded to invasive data, replicating the invasive procedure. The primary objective is to assess the agreement between the predicted FFRCT post-PCI derived from the Planner and invasive FFR. A total of 127 patients will be included in the study. RESULTS: Patient enrollment started in February 2019. Until December 2020, 100 patients have been included. Mean age was 64.1 ± 9.03, 76% were males and 24% diabetics. The target vessels for PCI were LAD 83%, LCX 6%, and RCA 11%. The final results are expected in 2021. CONCLUSION: This study will determine the accuracy and precision of the FFRCT Planner to predict post-PCI FFR in patients with chronic coronary syndromes undergoing percutaneous revascularization.2021年04月, Clinical cardiology, 44(4) (4), 446 - 454, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Clinical implications of proximal optimisation technique (POT) for bifurcation lesions have not been investigated in a randomised controlled trial. AIMS: This study aimed to investigate whether proximal optimisation technique (POT) is superior in terms of stent apposition compared with the conventional kissing balloon technique (KBT) in real-life bifurcation lesions using optical coherence tomography (OCT). METHODS: A total of 120 patients from 15 centres were randomised into two groups: POT followed by side branch dilation or KBT. Finally, 57 and 58 patients in the POT and KBT groups, respectively, were analysed. OCT was performed at baseline, immediately after wire recrossing to the side branch, and at the final procedure. RESULTS: The primary endpoint was the rate of malapposed struts assessed by the final OCT. The rate of malapposed struts did not differ between the POT and KBT groups (in-stent proximal site: 10.4% vs. 7.7%, p=0.33; bifurcation core: 1.4% vs. 1.1%, p=0.67; core's distal edge: 6.2% vs. 5.3%, p=0.59). More additional treatments were required among the POT group (40.4% vs. 6.9%, p<0.01). At 1-year follow-up, only one patient in each group underwent target lesion revascularisation (2.0% vs. 1.9%). CONCLUSIONS: POT followed by side branch dilation did not show any advantages over conventional KBT in terms of stent apposition, however, the excellent mid-term clinical outcomes were observed in both strategies.2021年03月, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 17(9) (9), 747 - 756, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本循環器学会, 2021年03月, 日本循環器学会学術集会抄録集, 85回, CS3 - 4, 日本語PCIのための心筋虚血評価-冠血流予備能の測定に迫る- 心臓CT検査およびFFRCTに対する当院の取り組みについて
- Assessment of frailty is important for risk stratification among the elderly with severe aortic stenosis (AS) when considering interventions such as surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). However, evidence of the impact of preoperative frailty on short-term postoperative outcomes or functional recovery is limited. This retrospective study included 234 consecutive patients with severe AS who underwent SAVR or TAVR at Kobe University Hospital between Dec 2013 and Dec 2019. Primary outcomes were postoperative complications, postoperative 6-min walking distance (6MWD), and home discharge rates. The mean age was 82 ± 6.6 years. There were 169 (SAVR: 80, TAVR: 89) and 65 (SAVR: 20, TAVR: 45) patients in the non-frail and frail groups, respectively (p = 0.02). The postoperative complication rates in the frail group were significantly higher than those in the non-frail group [30.8% (SAVR: 35.0%, TAVR: 28.9%) vs. 10.7% (SAVR: 15.0%, TAVR: 6.7%), p < 0.001]. The home discharge rate in the non-frail group was significantly higher than that in the frail group [85.2% (SAVR: 81.2%, TAVR: 88.8%) vs. 49.2% (SAVR: 55.0%, TAVR: 46.7%), p < 0.001]. The postoperative 6MWD in the non-frail group was significantly longer than that in the frail group [299.3 ± 87.8 m (SAVR: 321.9 ± 90.8 m, TAVR: 281.1 ± 81.3 m) vs. 141.9 ± 92.4 m (SAVR: 167.8 ± 92.5 m, TAVR: 131.6 ± 91.3 m), p < 0.001]. The TAVR group did not show a decrease in the 6MWD after intervention, regardless of frailty. We report for the first time that preoperative frailty was strongly associated with postoperative complications, 6MWD, and home discharge rates following both SAVR and TAVR. Preoperative frailty assessment may provide useful indications for planning better individualized therapeutic interventions and supporting comprehensive intensive care before and after interventions.2021年02月, Heart and vessels, 36(8) (8), 1234 - 1245, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: The impact of reduction in glycemic excursion on coronary plaques remains unknown. This study aimed to elucidate whether a dipeptidyl peptidase 4 inhibitor could reduce the glycemic excursion and stabilize the coronary plaques compared with conventional management in coronary artery disease (CAD) patients with impaired glucose tolerance (IGT). METHODS: This was a multicenter, randomized controlled trial including CAD patients with IGT under lipid-lowering therapy receiving either vildagliptin (50 mg once a day) or no medication (control group) regarding glycemic treatment. The primary endpoint was changes in the minimum fibrous cap thickness and lipid arc in non-significant native coronary plaques detected by optical coherence tomography at 6 months after intervention. Glycemic variability expressed as the mean amplitude of glycemic excursion (MAGE) measured with a continuous glucose monitoring system was evaluated before and 6 months after intervention. RESULTS: A total of 20 participants with 47 lesions were allocated to either the vildagliptin group (10 participants, 22 lesions) or the control group (10 participants, 25 lesions). The adjusted difference of mean changes between the groups was - 18.8 mg/dl (95% confidence interval, - 30.8 to - 6.8) (p = 0.0064) for the MAGE (vildagliptin, - 20.1 ± 18.0 mg/dl vs. control, 2.6 ± 12.7 mg/dl), - 22.8° (- 40.6° to - 5.1°) (p = 0.0012) for the mean lipid arc (vildagliptin, - 9.0° ± 25.5° vs. control, 15.8° ± 16.8°), and 42.7 μm (15.3 to 70.1 μm) (p = 0.0022) for the minimum fibrous cap thickness (vildagliptin, 35.7 ± 50.8 μm vs. control, - 15.1 ± 25.2 μm). CONCLUSIONS: Vildagliptin could reduce the MAGE at 6 months and may be associated with the decreased lipid arc and increased minimum FCT of the coronary plaques in CAD patients with IGT as compared with the control group. These findings may represent its potential stabilization effect on coronary plaques, which are characteristic in this patient subset. Trial registration Registered in the UMIN clinical trial registry (UMIN000008620), Name of the registry: VOGUE trial, Date of registration: Aug 6, 2012, URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000010058.2021年02月, BMC cardiovascular disorders, 21(1) (1), 92 - 92, 英語, 国際誌研究論文（学術雑誌）
- To compare early vascular healing following cobalt-chromium everolimus-eluting stent (CoCr-EES) implantation between groups with or without aggressive stent expansion in patients treated by CoCr-EES for stable coronary artery disease (CAD). Seventy-one stable CAD lesions underwent CoCr-EES implantation and analysis of serial optical coherence tomography (OCT) images obtained post-procedure and at early-term (1- or 3-month) follow-up. The endpoints of this study were neointimal thickness at the time of 1- or 3-month OCT and presence and healing of stent edge dissection. Aggressive stent expansion was defined as a lesion complying with ILUMIEN III sizing protocol; that is, external elastic lamina (EEL) diameter minus maximum balloon diameter ≤ 0.25 mm. Comparing groups with and without aggressive stent expansion, median neointimal thickness at 1 and 3 months after CoCr-EES implantation was similar (1 month: 0.031 mm vs. 0.041 mm, respectively, p = 0.27; 3 months: 0.036 mm vs. 0.040 mm, respectively, p = 0.84). Regarding stent edge findings, the presence of any stent edge dissection immediately after percutaneous coronary intervention was also similar between the groups (25% vs. 15%, respectively; p = 0.30) and most stent edge dissections resolved completely within 3 months, regardless of location or dissection severity. After 1 year, no clinically driven target lesion revascularization or stent thrombosis was observed in either cohort. Even after aggressive stent expansion, early neointimal proliferation appeared modest with CoCr-EES implantation, and most stent edge dissections had resolved by 3 months. These findings may support the feasibility of EEL-based sizing by pre-stenting OCT.2021年02月, The international journal of cardiovascular imaging, 37(2) (2), 419 - 428, 英語, 国際誌研究論文（学術雑誌）
- 2021年01月, JACC. Cardiovascular imaging, 14(1) (1), 315 - 317, 英語, 国際誌
- BACKGROUND: Configurational changes in the proximal aorta are relevant to the procedural difficulty of transcatheter aortic valve implantation (TAVI). Among several morphological changes involving the ascending aorta, elongation is characteristics of elderly patients with aortic stenosis and can compromise the success and safety of TAVI. However, the effect of ascending aortic elongation on the overall morphology of the proximal aorta has not been established. AIMS: Our primary purpose was to investigate the effect of ascending aortic elongation on structural changes in the proximal aorta in TAVI candidates. MATERIALS & METHODS: In total, 121 consecutive patients with severe aortic stenosis (mean age, 84.5 ± 5.3 years; 69% women) who had undergone preprocedural computed tomography before TAVI were enrolled. We examined the structural anatomy of the proximal aorta in detail, focusing on its elongation, dilatation, tilting, rotation, and wedging. RESULTS: The mean length of the ascending aorta was 68.0 ± 9.2 mm, and the length was significantly correlated with dilatation (R = .278, p = .002), rightward tilting (R = .437, p < .001), clockwise rotation (R = .228, p = .018), and deep wedging (R = -.366, p < .001) of the proximal aorta. Elongation of the ascending aorta was correlated with dilatation, rightward tilting, clockwise rotation, and deep wedging of the proximal aorta in an elderly population with severe aortic stenosis. DISCUSSION: Appreciation of the clinical anatomy around the proximal aorta is required for clinicians involved in TAVI to estimate the procedural difficulty. CONCLUSION: Elongation of the ascending aorta was associated with dilatation, rightward tilting, clockwise rotation, and deep wedging of the proximal aorta.2020年11月, Clinical anatomy (New York, N.Y.), 33(8) (8), 1240 - 1248, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Second-generation drug-eluting stents (DES) reduce the incidence of stent thrombosis, even in patients with ST-segment elevated myocardial infarction (STEMI). However, the early local vascular healing after DES implantation in STEMI lesions, which mainly concerns stent thrombosis, is still unclear.Methods and Results:We attempted to determine early local vascular healing 3 months after cobalt-chromium everolimus-eluting stent (CoCr-EES) implantation in STEMI lesions relative to stable coronary artery disease (CAD) lesions. This prospective, multicenter study analyzed 96 total lesions (STEMI=49, stable CAD=51) by frequency domain-optical coherence tomography (FD-OCT) performed post-procedure and at the 3-month follow-up. Although CoCr-EES implanted in STEMI were almost entirely covered at 3 months, they had a relatively high incidence of uncovered struts compared with stable CAD (5.5% vs. 1.6%, P<0.001). Intrastent thrombus in the 2 groups was primarily resolved at the 3-month follow-up (STEMI: 91.7%→26.5%, stable CAD: 74.5%→11.8%). Regarding irregular protrusion, complete resolution was observed in stable CAD (21.6%→0%), while a few stents remained in STEMI (79.2%→8.2%). Although there were almost no changes for the serial change of average lumen area in STEMI, there were slight but significant decreases in stable CAD [STEMI 0.08 (-0.44, 0.55) mm2, stable CAD -0.35 (-0.55, 0.11) mm2; P=0.009]. CONCLUSIONS: Although strut coverage after CoCr-EES implantation for STEMI lesions was slightly delayed, the healing process appeared to be acceptable in both STEMI and stable CAD.2020年10月, Circulation journal : official journal of the Japanese Circulation Society, 84(11) (11), 1941 - 1948, 英語, 国内誌研究論文（学術雑誌）
- Intravascular optical coherence tomography is a high-resolution intracoronary imaging modality, providing a microscopic image of intravascular features. However, it has lower penetration depth than intravascular ultrasound. Recently, a second-generation optical frequency-domain imaging (OFDI) technique has been developed to provide greater penetration depth and faster pullback speed. However, there is little evidence supporting the efficacy of OFDI in patients with peripheral artery disease (PAD) undergoing endovascular treatment (EVT). We aimed to evaluate the ability of OFDI to visualize vessel walls from the superficial femoral artery (SFA) to the below-knee (BK) arteries, as well as the coronary arteries. This clinical trial is a single-center, single-arm, open-label study to be conducted in Japan. A total of 20 patients will be enrolled in this study. The primary endpoint is to obtain a clear image of the intravascular features of the SFA and BK arteries, specifically the visualization of ≥ 270° of the vessel lumen in ≥ 16 out of 21 cross sections. Obtaining clear images in ≥ 85% of cases will be regarded as confirmation of the ability of OFDI to visualize vessel walls from the SFA to the BK arteries. This is the first clinical trial to be conducted accordance with good clinical practice to expand the indications of OFDI for PAD patients undergoing EVT in Japan. The result of this study will help provide another imaging option during EVT in daily practice.2020年10月, Cardiovascular intervention and therapeutics, 35(4) (4), 385 - 391, 英語, 国内誌研究論文（学術雑誌）
- In the original publication of the article, the author group was published without full names and one of the co-authors' name was published incorrectly. The full names of author group and correct co-authors' name are given in this Correction.2020年10月, Cardiovascular intervention and therapeutics, 35(4) (4), 392 - 392, 英語, 国内誌研究論文（学術雑誌）
- Limited data exist on the comparison of clinical outcomes after first- and second-generation drug-eluting stent (DES) thrombosis. From the Retrospective Multicenter Registry of Stent Thrombosis (ST) After First- and Second-Generation DES Implantation registry, this study evaluated 655 ST patients (first-generation DES thrombosis [G1-ST], n = 342; second-generation DES thrombosis [G2-ST], n = 313). After propensity score matching, the final study population consisted of 159 matched patients. The primary end point was the cumulative 1-year incidence of mortality. The mortality after G2-ST at 1 year was similar to that after G1-ST (23.0% vs 22.9%, p = 0.76). Also, the G2-ST group showed a significantly lower rate of target lesion revascularization than the G1-ST group (9.7% vs 17.1%, p = 0.01). Risk factors of 1-year mortality included cardiogenic shock or arrest at the time of ST, multivessel ST, left ventricular ejection fraction ≤40%, advanced age, and final thrombolysis in myocardial infarction flow grade ≤2. In conclusion, patients with G2-ST showed a similar 1-year mortality to those with G1-ST, highlighting that ST remains a life-threatening complication in the second-generation DES era.2020年10月, The American journal of cardiology, 132, 52 - 58, 英語, 国際誌研究論文（学術雑誌）
- A sigmoid septum is a state of angulation between the basal interventricular septum and the ascending aorta. Although considered to have no clinical importance, it may cause left ventricular outflow tract obstruction (LVOTO) in a hypercontractile state. Percutaneous transluminal septal myocardial ablation (PTSMA) is a catheter-based therapy aimed at improving drug-refractory symptoms in patients with hypertrophic obstructive cardiomyopathy. Few studies have reported the use of PTSMA for patients with LVOTO caused by sigmoid septum. We present a successful case of a 71-year-old female patient who presented with a long history of exertional dyspnea. The presence of a sigmoid septum was revealed on echocardiography. At rest, the left ventricular outflow tract pressure gradient was low and there were no signs of systolic anterior motion (SAM) of the mitral valve; however, during Valsalva maneuver, the gradient increased significantly, and SAM could be seen. We successfully performed PTSMA, resulting in a significant lowering of the pressure gradient and disappearance of SAM. The patient's symptoms dramatically improved by the following day.2020年10月, Journal of cardiology cases, 22(4) (4), 159 - 162, 英語, 国内誌
. - BACKGROUND: In-stent neoatherosclerosis (NA) is a risk for future cardiovascular events through atherosclerotic progression in non-stented lesions. Using optical coherence tomography, this study assessed the efficacy of intensive therapy with 10 mg/day rosuvastatin plus 1,800 mg/day eicosapentaenoic acid (EPA) vs. standard 2.5 mg/day rosuvastatin therapy on native coronary plaques in patients with NA.Methods and Results:This was a subgroup analysis of the randomized LINK-IT trial, which was designed to compare changes in the lipid index in NA between intensive and standard therapy for 12 months. In all, 42 patients with native coronary plaques and NA were assessed. Compared with standard therapy, intensive therapy resulted in greater decreases in serum low-density lipoprotein cholesterol concentrations and greater increases in serum 18-hydroxyeicosapentaenoic acid concentrations, with significantly greater decreases in the lipid index and macrophage grade in both NA (-24 vs. 217 [P<0.001] and -15 vs. 24 [P<0.001], respectively) and native coronary plaques (-112 vs. 29 [P<0.001] and -17 vs. 1 [P<0.001], respectively) following intensive therapy. Although there was a greater increase in the macrophage grade in NA than in native coronary plaques in the standard therapy group, in the intensive therapy group there were comparable reductions in macrophage grade between NA and native coronary plaques. CONCLUSIONS: Compared with standard therapy, intensive therapy prevented atherosclerotic progression more effectively in native coronary plaques in patients with NA.2020年09月, Circulation journal : official journal of the Japanese Circulation Society, 84(10) (10), 1826 - 1836, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: A recent clinical trial demonstrated that optical frequency domain imaging (OFDI) guidance in percutaneous coronary intervention (PCI) is noninferior to intravascular ultrasound (IVUS) guidance in patients with coronary artery disease with regard to target vessel failure (composed of cardiac death, myocardial infarction attributed to the target vessel, and clinically-driven target vessel revascularization) at 12 months. The impact of OFDI guidance in PCI for patients with acute coronary syndrome (ACS) remains uncertain. METHODS: OPINION ACS is a multicenter, prospective, randomized, controlled, open-label, parallel group, non-inferiority trial in Japan. Eligible patients will be randomly assigned to receive either OFDI- or IVUS-guided PCI. PCI is performed using the sirolimus-eluting stent in accordance with certain OFDI and IVUS criteria for optimal stent deployment. All patients will undergo follow-up angiography and OFDI imaging at 8 months. The primary endpoint is the minimum lumen area, as measured by OFDI at 8 months. CONCLUSION: The OPINION ACS trial outcomes will provide insights regarding the impact of OFDI-guided PCI on in-stent restenosis at 8 months in patients with ACS.2020年09月, Journal of cardiology, 76(3) (3), 317 - 321, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Although balloon angioplasty for femoropopliteal artery lesions has been associated with restenosis rates of up to 60% at 12 months, the mechanism of restenosis has not been fully evaluated. The aim of this study was to evaluate the relationship between the vascular features observed on optical frequency domain imaging (OFDI) before and after balloon angioplasty of femoropopliteal artery lesions, and restenosis at 6 months. This study was a prospective multicenter single arm study. OFDI was performed before and after balloon angioplasty and plaque characteristics and vascular features, along with de novo lesions, were assessed. The primary outcome was the presence or absence of restenosis 6 months after balloon angioplasty. Residual platelet reactivity was assessed according to VerifyNow platelet reactivity units (PRUs). The number of patients completing 6 months of follow-up was 47, of which 14 had developed restenosis. Maximum thickness of the dissection flap (odds ratio (OR) 2.71; 95% confidence interval [0.9-8.0]; p = 0.071) and lesion length were identified as risk factors for restenosis (OR 1.015; 95% confidence interval [0.001-0.029]; p = 0.039). The mean PRU at the time of treatment in patients with restenosis was significantly higher than in those without restenosis (286.3 ± 82.6 vs. 208.5 ± 03.6, p = 0.026). Long lesions and major dissection on OFDI after balloon angioplasty for femoropopliteal artery lesions increase restenosis at 6 months. In addition, high residual platelet reactivity at the time of EVT may also be a risk factor for restenosis.Clinical Trial Registration Number UMIN000021120.2020年06月, Cardiovascular intervention and therapeutics, 36(3) (3), 321 - 329, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- Background: Coronary computed tomography angiography (CCTA)-derived fractional flow reserve (FFRCT) is an established tool for identifying lesion-specific ischemia that is now approved for use by the Japanese insurance system. However, current clinical reimbursement is strictly limited to institutions with designated appropriate use criteria (AUC). This study assessed differences in physicians' behavior (e.g., use and interpretation of FFRCT, final management) according to Japanese AUC and non-AUC site designation. Methods and Results: Of 5,083 patients in the ADVANCE Registry, 1,829 from Japan were enrolled in this study. Physicians' behavior after interrogating CCTA and FFRCT was analyzed separately according to AUC and non-AUC site designation. Compared with AUC sites, patients referred for FFRCT from non-AUC sites had a higher rate of negative FFRCT, less severe anatomic stenosis, and a slightly lower rate of management plan reclassification (51.2% vs. 61.3%), with near-identical utility in both groups. Actual care corresponded equally well to post-FFRCT plans in both groups. The likelihood of revascularization for positive or negative FFRCT was similar between the 2 groups. Importantly, AUC and non-AUC sites were equally unlikely to revascularize patients with negative FFRCT and stenosis >50% or patients with positive FFRCT and stenosis <50%. Conclusions: Compared with AUC sites, non-AUC sites had lower disease burden and reclassification of management plans, but nearly identical clinical integration. Actual care corresponded equally well to post-FFRCT recommendations at both sites.2020年06月, Circulation reports, 2(7) (7), 364 - 371, 英語, 国内誌研究論文（学術雑誌）
- OBJECTIVE: The purpose of this study was to identify a cut-off value to predict the resolution of incomplete-stent-apposition (ISA) after cobalt-chromium everolimus-eluting stent (CoCr-EES) implantation at early follow-up. BACKGROUND: To date, appropriate stent apposition at the acute period using intracoronary imaging has been recommended because persistent ISA is considered to be a risk factor for stent thrombosis. We examined the indices for resolving acute ISA. In particular, we determined the cut-off value for strut vessel distance (SV-distance) as visualized by optical coherence tomography (OCT) at 8 months after CoCr-EES implantation. However, the cut-off value of SV-distance for the earlier resolution of ISA is unclear. METHODS: A total of 95 cases and 103 stents were registered in the MECHANISM Elective substudy. The SV-distance was measured at the deepest site of the target malapposition and every 1 mm from the proximal edge to the distal edge of the mal-apposed area using OCT. Cut-off values for ISA resolution at 1 and 3 months were estimated by SV-distance using receiver operating characteristic analysis. RESULTS: The total number of analyzed struts was 14,418 at the 1-month follow-up and 11,986 at the 3-month follow-up. The optimal SV-distance cut-off values just after stent implantation to predict ISA resolution were 185 µm at the 1-month follow-up and 195 μm at the 3-month follow-up. CONCLUSION: For resolution of ISA, SV-distance cut-off values of 185 µm at 1 month postimplantation and 195 μm at 3 months postimplantation can be used as the index of endpoint of the percutaneous coronary intervention.2020年06月, Journal of cardiology, 75(6) (6), 641 - 647, 英語, 国際誌研究論文（学術雑誌）
- 2020年06月, JACC. Cardiovascular imaging, 13(6) (6), 1452 - 1454, 英語, 国際誌
- A 92-year-old man was referred to our hospital with decompensated heart failure. He was treated with diuretics and inotropic agents, but the clinical response was unsatisfactory. Echocardiography incidentally revealed an atrial septal defect (ASD) with a significant left-to-right shunt and pulmonary-to-systemic-blood-flow ratio of 2.36. Because the ASD was considered to be the primary cause of his treatment-resistant heart failure, the patient underwent transcatheter ASD closure. Shortly after shunt closure, his hemodynamics significantly improved, and he was discharged nine days later. This is an extremely rare case of a nonagenarian who showed an excellent clinical course after transcatheter ASD closure.2020年04月, Internal medicine (Tokyo, Japan), 59(8) (8), 1059 - 1063, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Cholesterol efflux from atherosclerotic lesion is a key function of high-density lipoprotein (HDL). Recently, we established a simple, high-throughput, cell-free assay to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as "cholesterol uptake capacity (CUC)". OBJECTIVE: To clarify the cross-sectional relationship between CUC and coronary plaque properties. METHODS: We enrolled 135 patients to measure CUC and assess the morphological features of angiographic stenosis by optical coherence tomography (OCT). We estimated the extent of the lipid-rich plaque by multiplying the mean lipid arc by lipid length (lipid index). The extent of the OCT-detected macrophage accumulation in the target plaque was semi-quantitatively estimated using a grading system. RESULTS: Lipid-rich plaque lesions were identified in 125 patients (92.6%). CUC was inversely associated with the lipid index (R = -0.348, P < 0.0001). In addition, CUC was also inversely associated with macrophage score (R = -0.327, P < 0.0001). Conversely, neither circulating levels of HDL cholesterol nor apoA1 showed a similar relationship. CONCLUSIONS: We demonstrated that CUC was inversely related to lipid-rich plaque burden and the extent of macrophage accumulation, suggesting that CUC could be useful for cardiovascular risk stratification.2020年04月, Clinica chimica acta; international journal of clinical chemistry, 503, 136 - 144, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Stent thrombosis (ST) remains a severe complication following stent implantation. We previously reported the risk factors for ST after 2nd-generation drug-eluting stent (DES) in the REAL-ST (Retrospective Multicenter Registry of ST After First- and Second-Generation DES Implantation) registry.Methods and Results:In this subanalysis, we aimed to reveal the difference in ST between right coronary (RCA) and left (LCA) coronary arteries. A total of 307 patients with ST were divided into the RCA-ST group (n=93) and the LCA-ST group (n=214). Multivariate analysis revealed younger age (odds ratio [OR] 0.96, 95% confidence interval [CI] 0.93-0.99, P=0.01), ostial lesion at the time of index percutaneous coronary intervention (OR 4.37, 95% CI 1.43-13.33, P=0.01), bifurcation lesion at the time of index PCI (OR 0.05, 95% CI 0.02-0.12, P<0.01), chronic total occlusion (CTO) lesion at the time of index PCI indication (OR 4.19, 95% CI 1.05-16.71, P=0.04), and use of prasugrel at the time of ST (OR 7.30, 95% CI 1.44-36.97, P=0.02) were significantly associated with RCA-ST. CONCLUSIONS: Younger age, ostial or CTO lesion, and use of prasugrel at the time of ST were prominent factors in RCA-ST, whereas bifurcation lesion was associated with LCA-ST. We should pay attention to the differences between RCA-ST and LCA-ST to prevent ST.2020年01月, Circulation journal : official journal of the Japanese Circulation Society, 84(2) (2), 169 - 177, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- In this document, the methods for the quantitative measurement and morphological assessment of optical coherence tomography (OCT)/optical frequency domain imaging images (OFDI) are briefly summarized. The focus is on the clinical application of OCT/OFDI to guide percutaneous coronary interventions.2020年01月, Cardiovascular intervention and therapeutics, 35(1) (1), 13 - 18, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- AIMS: We aimed to assess the effect of 10 mg/day of rosuvastatin plus eicosapentaenoic acid (EPA) versus 2.5 mg/day of rosuvastatin on the extent of neoatherosclerosis using optical coherence tomography (OCT). METHODS AND RESULTS: We randomly assigned 50 patients with non-obstructive neoatherosclerotic plaques detected on OCT to receive either rosuvastatin 10 mg/day and EPA 1,800 mg/day (intensive therapy group) or rosuvastatin 2.5 mg (standard therapy group). Follow-up OCT was performed one year later to evaluate serial changes in neoatherosclerosis. The serum low-density lipoprotein cholesterol (LDL-C) level decreased significantly from baseline to 12-month follow-up in the intensive therapy group (89 mg/dL to 70 mg/dL; p<0.001), while no change occurred in the standard therapy group. Lipid index change and percent changes in macrophage grade were significantly lower in the intensive therapy group than in the standard therapy group (-53.6 vs 310.1, p=0.001; -37.0% vs 35.3%, p<0.001; respectively). Percent changes in lipid index and macrophage grade were positively correlated with the changes in serum LDL-C and C-reactive protein levels, and negatively correlated with the change in serum EPA/arachidonic acid and 18-hydroxyeicosapentaenoic acid (EPA bioactive metabolite) level. CONCLUSIONS: Compared with rosuvastatin 2.5 mg/day, rosuvastatin 10 mg/day and EPA 1,800 mg/day significantly stabilised non-obstructive neoatherosclerotic plaques. CLINICAL TRIAL REGISTRATION: UMIN ID: UMIN000012576. https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000014711.2019年12月, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 15(12) (12), e1099-e1106, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- OBJECTIVES: We explored the anatomical, plaque, and hemodynamic characteristics of high-risk non-obstructive coronary lesions that caused acute coronary syndrome (ACS). METHODS: From the EMERALD study which included ACS patients with available coronary CT angiography (CCTA) before the ACS, non-obstructive lesions (percent diameter stenosis < 50%) were selected. CCTA images were analyzed for lesion characteristics by independent CCTA and computational fluid dynamics core laboratories. The relative importance of each characteristic was assessed by information gain. RESULTS: Of the 132 lesions, 24 were the culprit for ACS. The culprit lesions showed a larger change in FFRCT across the lesion (ΔFFRCT) than non-culprit lesions (0.08 ± 0.07 vs 0.05 ± 0.05, p = 0.012). ΔFFRCT showed the highest information gain (0.051, 95% confidence interval [CI] 0.050-0.052), followed by low-attenuation plaque (0.028, 95% CI 0.027-0.029) and plaque volume (0.023, 95% CI 0.022-0.024). Lesions with higher ΔFFRCT or low-attenuation plaque showed an increased risk of ACS (hazard ratio [HR] 3.25, 95% CI 1.31-8.04, p = 0.010 for ΔFFRCT; HR 2.60, 95% CI 1.36-4.95, p = 0.004 for low-attenuation plaque). The prediction model including ΔFFRCT, low-attenuation plaque and plaque volume showed the highest ability in ACS prediction (AUC 0.725, 95% CI 0.724-0.727). CONCLUSION: Non-obstructive lesions with higher ΔFFRCT or low-attenuation plaque showed a higher risk of ACS. The integration of anatomical, plaque, and hemodynamic characteristics can improve the noninvasive prediction of ACS risk in non-obstructive lesions. KEY POINTS: • Change in FFR CT across the lesion (ΔFFR CT ) was the most important predictor of ACS risk in non-obstructive lesions. • Non-obstructive lesions with higher ΔFFR CT or low-attenuation plaque were associated with a higher risk of ACS. • The integration of anatomical, plaque, and hemodynamic characteristics can improve the noninvasive prediction of ACS risk.2019年11月, European radiology, 29(11) (11), 6119 - 6128, 英語, 国際誌研究論文（学術雑誌）
- The purpose of this study was to clarify a cut-off value for acute incomplete stent apposition (ISA) volume and maximum-depth to predict ISA resolution at 1- and 3-month follow-up in patients treated with cobalt-chromium everolimus-eluting stents. In total, 95 cases and 103 stents were registered in the MECHANISM-Elective sub-study. Acute ISA-volume was measured by the trapezoid rule. ISA resolution of cut-off value at 1- and 3-month was estimated by ISA-volume and maximum-depth using receiver operatorating characteristic curve analysis. The total number of analysed acute ISAs was 202 in the 1-month group and 225 in the 3-month group. A total of 123 ISAs at 1-month and a total of 169 ISAs at 3-month had been resolved. The cut-off value of ISA resolution by ISA-volume was 0.169 mm3 at 1-month (AUC: 0.725, sensitivity: 72.2%, specificity: 61.0%) and 0.295 mm3 at 3-month (AUC: 0.757, sensitivity: 75.0%, specificity: 60.4%). The cut-off value of ISA resolution by ISA maximum-depth demonstrated was 0.285 mm at 1-month (area under curve (AUC): 0.789, sensitivity: 70.9%, specificity: 69.9%) and 0.305 mm at 3-month (AUC: 0.663, sensitivity: 60.7%, specificity: 66.9%). Incidence of ISA resolution was significantly lower in combination with cut-off values of ISA-volume and maximum-depth (33%, p < 0.001, at 1-month; 56%, p = 0.003, at 3-month). Combining the cut-off value of ISA-volume with the maximum-depth might be helpful to consider the endpoint of the PCI procedure.2019年11月, The international journal of cardiovascular imaging, 35(11) (11), 1979 - 1987, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Analysis of pooled clinical data has shown the safety of 3 months of dual antiplatelet therapy with everolimus-eluting cobalt-chromium stents (Co-Cr EESs). This study evaluated early and mid-term vascular responses to Co-Cr EESs in patients with stable coronary artery disease. METHODS: The Multicenter Comparison of Early and Late Vascular Responses to Everolimus-Eluting Cobalt-Chromium Stent and Platelet Aggregation Studies in Patients With Stable Angina Managed as Elective Case (MECHANISM-Elective) study (NCT02014818) is a multicenter optical coherence tomography (OCT) registry. Enrolled patients were evaluated by OCT immediately after everolimus-eluting stent implantation were prospectively allocated to 1 month (n = 50) or 3 months (n = 50) OCT follow-up and then received a 12-month OCT evaluation. The incidences of intrastent thrombus (IS-Th) and irregular protrusion (IRP) were also assessed. RESULTS: The percentage of uncovered struts was 6.4% ± 10.3% at 1 month (P < 0.001 vs. postprocedure) and 0.5% ± 0.9% at 12 months (P < 0.001 vs. 1 month). The corresponding values in the 3-month cohort were 2.0% ± 2.5% (P < 0.001 vs. postprocedure) and 0.5% ± 1.5% (P < 0.001 vs. 3 months). The incidence of IS-Th was 32.7% at 1 month, 5.4% at 3 months, and 2.0% at 12 months. IRP was observed in 21.8% of patients post-EES but had totally resolved at 1, 3, and 12 months. CONCLUSION: Early and mid-term vascular reactions after Co-Cr EES implantation in stable patients with coronary artery disease in the MECHANISM-Elective included dynamic resolution of IS-Th and IRP and rapid decrease in uncovered struts. Thus, EES may allow shortening of dual antiplatelet therapy duration less than 3 months in this patient subset.2019年11月, The Canadian journal of cardiology, 35(11) (11), 1513 - 1522, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- The aim of this study was to elucidate the vascular responses to paclitaxel-eluting stent (Zilver PTX stent) in superficial femoral artery lesion at different elapsed times using angioscopy. Patients who received Zilver PTX stent implantation from five centers were enrolled. We performed angioscopic examinations at 2, 6, and 12 months after implantation and evaluated neointimal coverage (NIC) grade, intra-stent thrombus (IS-Th) grade, and presence of yellow plaque. NIC grade 0 was defined as stent struts exposed; grade 1, struts transparently visible although covered; grade 2, struts embedded in the neointima, but translucent; and grade 3, struts fully embedded and invisible. IS-Th was graded as follows: grade 0 (none), 1 (focal), and 2 (diffusely spread). Angioscopic follow-up evaluation was performed at 2 months (25 patients, 42 lesions), 6 months (18 patients, 23 stents), and 12 months (14 patients, 24 stents) after stent implantation. Dominant NIC grade significantly increased over time; however, 16.3% of the cases had NIC grade 1 or 2 at 12 months. IS-Th grade decreased; however IS-Th and yellow plaque were persistently observed in 62.5% and 83.3% cases, respectively, at 12 months. An ongoing healing response was observed at 12 months after implantation; however, thrombogenic findings were noted. Prolonged dual antiplatelet therapy could potentially enhance the clinical utility of Zilver PTX.2019年10月, The international journal of cardiovascular imaging, 35(10) (10), 1777 - 1784, 英語, 国際誌研究論文（学術雑誌）
- 2019年09月, Circulation journal : official journal of the Japanese Circulation Society, 83(10) (10), 2025 - 2033, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- (一社)日本心血管インターベンション治療学会, 2019年09月, 日本心血管インターベンション治療学会抄録集, 28回, [MO11 - 004], 英語Ruptured plaqueとNon-Ruptured plaqueによるST上昇型心筋梗塞に対するPCI後の血管治癒反応の違いについての検討
- Background The risk factors and long-term clinical outcomes of patients with definite stent thrombosis (ST) after second-generation drug-eluting stent (DES) implantation have not yet been adequately assessed. Methods and Results The REAL-ST (Retrospective Multicenter Registry of ST After First- and Second-Generation DES Implantation) included 313 definite ST of second-generation DES (early ST, n=179; late ST, n=66; very late ST, n=68). Four patients without definite ST of second-generation DES were identified as control patients for each ST case. Risk factors of definite ST were mostly different according to the timing of ST: ST-segment-elevation myocardial infarction, non-ST-segment-elevation myocardial infarction, and unstable angina at presentation, current smoking, left ventricular ejection fraction <40%, prior percutaneous coronary intervention, stent overlap, severely calcified lesion, left main coronary artery lesion, proximal left anterior descending lesion, postdiameter stenosis ≥20%, for early ST; age <70 years, ST-segment-elevation myocardial infarction at presentation, hemodialysis, left ventricular ejection fraction <40%, in-stent restenosis, and severely calcified lesion for late ST; and proximal left anterior descending lesion and in-stent restenosis for very late ST. Cumulative 4-year incidence of death after the index ST events was significantly higher in the ST patients than control patients (33.0% versus 12.3%, P<0.001 for early ST versus control; 30.6% versus 14.2%, P<0.001 for late ST versus control; and 28.0% versus 13.0%, P<0.001 for very late ST versus control, respectively). Conclusions Risk factors of definite ST after second-generation DES implantation were mostly different according to the timing of ST. Definite ST patients showed unfavorable long-term clinical outcomes compared with those without definite ST. Clinical Trial Registration URL: https://www.umin.ac.jp . Unique identifier: UMIN000025181.2019年06月, Circulation. Cardiovascular interventions, 12(6) (6), e007822, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Coronary computed tomography angiography (cCTA)-derived fractional flow reserve (FFRCT) is a promising diagnostic method for the evaluation of coronary artery disease (CAD). However, clinical data regarding FFRCTin Japan are scarce, so we assessed the clinical impact of using FFRCTin a Japanese population.Methods and Results:The ADVANCE registry is an international prospective FFRCTregistry of patients suspected of CAD. Of 5,083 patients, 1,829 subjects enrolled from Japan were analyzed. Demographics, symptoms, cCTA, FFRCT, treatment strategy, and 90-day major cardiovascular events (MACE) were assessed. Reclassification of treatment strategy between cCTA alone and cCTA+FFRCToccurred in 55.8% of site investigations and in 56.9% in the core laboratory analysis. Patients with positive FFR (FFRCT≤0.80) were less likely to have non-obstructive disease on invasive coronary angiography than patients with negative FFR (FFRCT>0.80) (20.5% vs. 46.1%, P=0.0001). After FFRCT, 67.0% of patients with positive results underwent revascularization, whereas 96.1% of patients with negative FFRCTwere medically treated. MACE occurred in 5 patients with positive FFRCT, but none occurred in patients with negative FFRCTwithin 90 days. CONCLUSIONS: In this Japanese population, FFRCTmodified the treatment strategy in more than half of the patients. FFRCTshowed potential for stratifying patients suspected of CAD properly into invasive or non-invasive management pathways.2019年05月, Circulation journal : official journal of the Japanese Circulation Society, 83(6) (6), 1293 - 1301, 英語, 国内誌研究論文（学術雑誌）
- Background We evaluated the importance of high-density lipoprotein (HDL) functionality for target-lesion revascularization in patients treated with coronary stents using a rapid cell-free assay system to evaluate the functional capacity of HDL to accept additional cholesterol (cholesterol-uptake capacity; CUC). Methods and Results From an optical coherence tomography (OCT) registry of patients treated with coronary stents, 207 patients were enrolled and their HDL was functionally evaluated by measuring the CUC. Follow-up OCT was performed (median duration, 24.5 months after stenting) to evaluate the presence of neoatherosclerosis. Clinical follow-up was performed to assess target-lesion revascularization for a median duration of 42.3 months after stent implantation. Neoatherosclerosis was identified in 37 patients (17.9%). Multivariate logistic regression analysis revealed that a decreased CUC was independently associated with neoatherosclerosis (odds ratio, 0.799; P<0.001). The CUC showed a significant inverse correlation with incidence of target-lesion revascularization (odds ratio, 0.887; P=0.003) and with lipid accumulation inside stents, suggesting that neoatherosclerosis contributes to the association between CUC and target-lesion revascularization. Conclusions Impaired HDL functionality, detected as decreased CUC, might lead to future stent failure by provoking atherogenic changes of the neointima within stents. Both quantitative and qualitative assessments of HDL might enable the improved prediction of clinical outcomes after stent implantation.2019年05月, Journal of the American Heart Association, 8(9) (9), e011975, 英語, 国際誌研究論文（学術雑誌）
- Background: While hemodynamics and exercise capacity in patients with chronic thromboembolic pulmonary hypertension (CTEPH) can be improved by invasive therapy such as pulmonary endarterectomy (PEA) and balloon pulmonary angioplasty (BPA), there has been little data on the health-related quality of life (HRQOL) in such patients. Methods and Results: This single-center and observational study compared the impact of invasive therapy on HRQOL. We utilized the Medical Outcome Study 36-Item Short Health Survey (SF-36) to measure HRQOL and compared HRQOL changes after PEA and BPA. A total of 48 patients were diagnosed with CTEPH. Of these, 39 patients completed questionnaires before and after invasive therapy. The PEA group (n=15) and the BPA group (n=24) had similar improvements in clinical parameters. With regard to HRQOL score, both groups had fairly low scores in physical functioning (PF), role physical (RP), general health (GH), social functioning (SF), role emotional (RE), and physical component summary (PCS) at baseline. PF, GH, vitality (VT), mental health (MH), and PCS had significant improvements in the PEA group while PCS and all subscales except for bodily pain (BP) had significant improvements in the BPA group. Furthermore, changes between baseline and follow-up were not significantly different between the 2 groups. Conclusions: BPA for patients who are ineligible for PEA can recover HRQOL to a similar level to that achieved by PEA.2019年04月, Circulation reports, 1(5) (5), 228 - 234, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- (一社)日本循環器学会, 2019年03月, 日本循環器学会学術集会抄録集, 83回, OJ16 - 5, 英語ステント留置後の不規則な膨隆は将来の新たなアテローム性動脈硬化症の発現と関連する MECHANISM-AMI研究からの知見(Post-stent Irregular Protrusion is Associated with Future Development of Neoatherosclerosis: Insights from the MECHANISM-AMI Study)
- (一社)日本循環器学会, 2019年03月, 日本循環器学会学術集会抄録集, 83回, OJ39 - 4, 英語安定狭心症とST上昇型心筋梗塞間で異なるeverolimus溶出性ステント留置に対する血管反応 MECHANISM試験からの洞察(Different Vascular Reaction to Everolimus-eluting Stents Implantation between Stable Angina and ST Elevation Myocardial Infarction: Insights from MECHANISM Studies)
- (一社)日本循環器学会, 2019年03月, 日本循環器学会学術集会抄録集, 83回, SY12 - 2, 英語JDS-JCSジョイントシンポ(Controversy or Debate)-"Stop DM for Stop CVD"生命予後改善のための糖尿病管理とは ブドウ糖変動が安定冠動脈疾患患者の心血管転帰に与える影響(The Impact of Glucose Fluctuation on Cardiovascular Outcome in Patients with Stable Coronary Artery Disease)
- It is well known that patent ductus arteriosus (PDA) in adults, especially in the elderly, differs from that in pediatric patients. A 68-year-old woman with a PDA with focal calcification at the aortic orifice of the ampulla with a minimum diameter of 4.0 mm and length of 14.8 mm, was treated with a 10/8-mm Amplatzer duct occluder (ADO) (St. Jude Medical Corp, St. Paul, MN, USA). After device implantation, systolic blood pressure (BP) increased to approximately 220 mmHg from 130 mmHg. She experienced transient dyspnea from hypertensive heart failure, which improved through continuous infusion of anti-hypertensive agents. She suddenly felt pressure on her chest 12 h post-procedure and collapsed. Surgical thoracotomy revealed an ascending aortic dissection into the pericardial space. In retrospective review, the ADO may have been slightly deformed by fluoroscopy. The complication may have been triggered by the resilience caused by device deformation, damage to the aortic wall due to the aortic side of the device, uneven elasticity of the arterial wall, and uncontrolled excessively high blood pressure.2019年03月, Journal of cardiology cases, 19(3) (3), 85 - 88, 英語, 国内誌
. [査読有り] - BACKGROUND: Trans-fatty acid (TFA) intake increases the risk of coronary artery disease (CAD). Our previous cross-sectional survey showed that middle-aged patients with CAD in Japan have elevated serum TFA. In this study, we longitudinally investigated whether elevated TFA is a risk factor in the secondary prevention of CAD for the same-age patients. Methods and Results: A total of 112 patients (age, 21-66 years) who underwent percutaneous coronary intervention were followed up for up to 2 years. Serum elaidic acid was measured using gas chromatography/mass spectrometry as a marker of TFA intake and divided into quartiles. The primary endpoint was ischemia-driven target lesion revascularization (TLR). The hazard ratio (HR) for TLR increased significantly with higher serum elaidic acid (P<0.01). The significant positive trend remained unchanged after adjusting for conventional lipid profile and bare-metal stent usage. In contrast, although triglycerides and low-density lipoprotein cholesterol were positively correlated with elaidic acid, they were not associated with TLR. On multivariable Cox proportional hazard analysis, elevated elaidic acid was independently associated with TLR risk after adjusting for conventional coronary risks (HR, 10.7, P<0.01). CONCLUSIONS: Elevated elaidic acid is associated with higher TLR rate in middle-aged patients with CAD, suggesting that excessive TFA intake is becoming a serious health problem in Japan.2019年03月, Circ J, 83(5) (5), 1032 - 1038, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Although a recent clinical trial demonstrated that alirocumab, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, significantly reduces the incidence of acute coronary events, the impact of alirocumab on plaque stabilization remains uncertain. The Efficacy of ALirocumab for Thin-cap fibroatheroma in patients with coronary Artery disease estImated by optical coherence tomogRaphy (ALTAIR) study will investigate the effect of alirocumab on thin-cap fibroatheroma (TCFA) in Japanese patients who underwent recent percutaneous coronary intervention (PCI). METHODS AND DESIGN: ALTAIR is a phase IV, open-label, randomized, parallel-group, single-center study involving blinded optical coherence tomography (OCT) image analysis in Japanese adults hospitalized for PCI and having suboptimal control of low-density lipoprotein cholesterol (LDL-C) levels (>70mg/dL) despite statin therapy. Patients will be randomized (1:1) to the alirocumab arm (alirocumab 75mg every 2 weeks added to rosuvastatin 10mg/day) or the standard-of-care arm (rosuvastatin 10mg/day, with initiation and/or dose adjustment of non-statin lipid-lowering to achieve an LDL-C target of <70mg/dL). OCT imaging will be conducted at baseline and at week 36 (post-treatment). The primary objective is to compare the alirocumab and standard-of-care arms regarding the change in TCFA fibrous-cap thickness after 9 months of treatment. CONCLUSION: The outcomes of ALTAIR (ClinicalTrials.gov identifier: NCT03552432) will provide insights into the effect of alirocumab on plaque vulnerability following PCI in patients with suboptimal LDL-C control despite stable statin therapy.2019年03月, J Cardiol, 73(3) (3), 228 - 232, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Japanese Circulation Society, 2019年02月, Circulation Reports, 1(2) (2), 107 - 111研究論文（学術雑誌）
- 2019年01月, JACC. Cardiovascular interventions, 12(1) (1), e5-e7 - e7, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- The impact of dual antiplatelet therapy (DAPT) with adjusted-dose (3.75 mg/day) prasugrel for Japanese patients has not been fully investigated in terms of local arterial healing following the elective percutaneous coronary intervention (PCI). The ROUTE-01 elective study was a prospective, 12-center and single-arm registry that enrolled 123 patients who underwent elective PCI with everolimus-eluting stents (EESs) under DAPT with a combination of adjusted-dose prasugrel and aspirin. Serial optical coherence tomography (OCT) was performed at the index PCI and 9-month follow-up to assess the relationship between in-stent thorombus (IST) and residual platelet reactivity measuring platelet reactivity unit (PRU). The patients were classified as extensive, intermediate, and poor metabolizers by cytochrome P450 2C19 (CYP2C19) loss-of-function polymorphisms. The prevalence of IST was 9.0% by 9-month OCT, with no difference amongst the three groups (p = 0.886). The incidences of malapposed and uncovered struts were not different among the groups. PRU was not statistically different among the groups. In multivariate logistic regression analysis, the independent predictor for IST on 9-month OCT was irregular protrusion (odds ratio = 8.952, p = 0.037) on post-PCI OCT, not CYP2C19 loss-of-function polymorphisms. An adequate anti-thrombotic effect with an acceptable incidence of IST was observed irrespective of CYP2C19 loss-of-function polymorphisms. Our data suggests that adjusted-dose prasugrel and aspirin is a feasible treatment option in Japanese patients treated with EESs in elective PCI.2019年01月, Heart Vessels, 34(6) (6), 936 - 947, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- The use of cobalt-chromium everolimus-eluting stents (CoCr-EES) for ST-segment elevation myocardial infarction (STEMI) reduces the incidence of stent thrombosis compared with bare metal stents, and a substantial difference is apparent in the initial 2 weeks. However, vascular behavior during this early period remains unclear. This was a prospective study (MECHANISM-AMI-2W) to investigate early vascular responses in STEMI patients immediately after CoCr-EES implantation and at 2-week follow-up using frequency domain-optical coherence tomography (FD-OCT). The study enrolled 52 patients (age 63.7 ± 11.7 years, male 85.0%), of whom 44 patients were available for complete serial FD-OCT analyses. Both % uncovered struts and % malapposed struts were improved at 2-week follow-up (63 ± 20 vs. 21 ± 14%, p < 0.0001 and 7.3 ± 9.0 vs. 4.7 ± 5.9%, p = 0.005, respectively). Thrombus was decreased, with significant changes in longitudinal length to stent (28.8 ± 27.7 vs. 18.1 ± 20.2%, p = 0.0001) and maximal area (0.93 ± 0.84 vs. 0.65 ± 0.63 mm2, p = 0.034). As a result, the average lumen area was significantly larger at 2 weeks (6.49 ± 1.82 vs. 6.71 ± 1.89 mm2, p = 0.048, respectively). The number of dissection flaps was lower (0.86 ± 1.11 vs. 0.52 ± 0.90%, p = 0.024). In conclusion, this study showed early vascular responses to CoCr-EES for STEMI lesions-including a significant reduction of thrombus-that resulted in lumen enlargement, earlier progression of strut coverage, and improvements in strut apposition and dissection. The combination of these factors may therefore be responsible for the safety of CoCr-EES within the initial 2 weeks.2019年01月, Cardiovasc Interv Ther, 34(1) (1), 14 - 24, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- Impact of Cytochrome P450 2C19 Reduced-Function Polymorphism on Lesions and Clinical Outcome in Japanese Patients After Drug-eluting Stent ImplantationWe previously reported that the cytochrome P450 (CYP) 2C19 reduced-function polymorphism was associated with decreased responsiveness to clopidogrel and intra-stent thrombus formation, as well as subsequent ischemic events after drug-eluting stent (DES) implantation. However, the relationship between the polymorphism and bleeding events remains unclear. Among 1427 consecutive patients who underwent DES implantation at Kobe University Hospital, 247 patients (341 lesions) were enrolled for this prospective observational study. All patients underwent follow-up optical coherence tomography (OCT) at 8 months and CYP2C19 genotyping. The patients were divided into three groups according to the phenotypic effect of the CYP2C19 polymorphism: extensive metabolizers (EM), intermediate metabolizers (IM), and poor metabolizers (PM). OCT findings, and ischemic and bleeding events were compared among the three groups. The frequency of intra-stent thrombi showed an increasing pattern among the patients with EM, IM, and PM (13.3%, 22.6%, and 33.3%, respectively; p = 0.04). The incidence of major adverse cardiovascular events (MACE) also showed an increase across the three groups from extensive to poor metabolizers (7.8%, 10.5%, and 33.3%, respectively; p < 0.01), whereas the frequency of bleeding showed no significant difference among the groups (15.6%, 19.4%, and 21.2%, respectively; p = 0.69). The CYP2C19 polymorphism is associated with the frequency of MACE, but is not related to the incidence of bleeding after percutaneous coronary intervention in Japanese patients receiving clopidogrel.2018年09月, Kobe J Med Sci, 64(2) (2), E56 - E63, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Although a prospective randomized control study revealed that 3-month dual anti-platelet therapy (DAPT) is safe and does not compromise the efficacy of everolimus-eluting stent (EES) in selected patients, detailed vessel healing at early phase after EES implantation has yet to be investigated in Japanese patients. METHODS AND RESULTS: A total of 27 lesions in 19 patients treated with EES were serially evaluated by using optical coherence tomography (OCT) at 3, 6, and 12 months after stent implantation. In addition to standard quantitative OCT parameters, the percentage of stents with peri-strut low-intensity area (PLIA, a region around stent struts homogenously showing lesser intensity than the surrounding tissue, suggesting fibrin deposition or impaired neointima maturation) and that with in-stent thrombi were evaluated. There was a significant, but small increase in neointimal thickness (63±17μm; 83±30μm; and 111±44μm, respectively; p=0.006) and small decrease in average lumen area (6.80±2.57mm2, 6.62±2.58mm2, 6.33±2.58mm2, p=0.038) from the 3- to the 12-month follow-up. The incidences of uncovered and malapposed struts were low at 3 months and did not significantly change at 6 months and 12 months (3.01±4.43; 2.45±3.75; and 1.47±3.16, p=0.143, and 0.75±0.65; 0.63±0.73; and 0.58±1.42, p=0.162, respectively). Also, frequency of struts with PLIA was already low at three months and significantly decreased during the follow-up (6.4±6.5; 4.6±5.4; and 2.3±3.3, respectively; p=0.001). CONCLUSION: Favorable vessel healing was achieved at 3 months after EES implantation without neointimal hyperplasia which was persistently suppressed up to 12 months.2018年09月, J Cardiol., 72(3) (3), 193 - 199, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2018年08月, Heart Vessels., 33(8) (8), 837 - 845, 英語Vascular response to biolimus A-9 eluting stent in patients with shorter and prolonged dual antiplatelet therapy: optical coherence tomography sub-study of the NIPPON trial.[査読有り]研究論文（学術雑誌）
- An 82-year-old man with severe aortic stenosis and idiopathic pulmonary fibrosis (IPF) underwent transcatheter aortic valve implantation (TAVI) under general anesthesia. However, following a successful TAVI procedure, he developed progressive respiratory failure because of the exacerbation of IPF. Despite the use of immunosuppressants, the patient could not be saved and he died of respiratory failure. Although TAVI is a less invasive procedure compared to conventional surgical aortic valve replacement, it is currently selected for management of severely ill, frail, and elderly patients. This case highlights the potential risk of IPF exacerbation following a TAVI procedure performed under general anesthesia.2018年08月, J CARDIOL CASES, 18(5) (5), 171 - 174, 英語, 国内誌
. [査読有り]研究論文（学術雑誌） - 2018年08月, Circ J, 82(9) (9), 2449, 英語Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve Assessment: Many Roads to Reach the Same Goal - Reply[査読有り]研究論文（学術雑誌）
- Intra-stent thrombus (IS-Th) formed immediately after percutaneous coronary intervention (PCI) is associated with subsequent adverse coronary events. However, the impact of on-treatment platelet reactivity on IS-Th is unknown. PRASFIT-Elective is a multicenter study of PCI patients receiving prasugrel (20/3.75 mg, loading/maintenance dose) or clopidogrel (300/75 mg), with aspirin (100 mg). Among the 742 study patients, 111 were pre-specified for the OCT sub-study. Of these, 82 underwent OCT immediately after PCI to assess IS-Th and at an 8-month follow-up to evaluate the fate of the IS-Th. Lesions were considered resolved when IS-Th were detected after PCI but not on the follow-up or persistent when IS-Th were observed on both scans. The P2Y12 Reactive Unit (PRU) value was determined at the initial PCI and 4 and 48 weeks post-PCI. In 76 patients (86 lesions), we detected 230 IS-Th initially, and 196 IS-Th (85.2%) were resolved at the 8-month OCT. At PCI, but not 4 or 48 weeks after, the resolved IS-Th group had a lower PRU than the persistent IS-Th group (199 ± 101 vs. 266 ± 102, p = 0.008). Multivariate logistic regression analyses revealed that lower PRU at PCI and less calcified lesions were independent predictive factors for the resolution of IS-Th. Local lesion-related factors and lower on-treatment platelet reactivity at the time of PCI may contribute to the resolution of IS-Th after EES implantation, potentially improving clinical outcome.2018年07月, Heart Vessels., 33(12) (12), 1423 - 1433, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- 2018年07月, Heart Vessels., 英語Impact of the angiographic burden on the incidence of out-of-hospital ventricular fibrillation in patients with acute myocardial infarction.[査読有り]研究論文（学術雑誌）
- Data presented in this article are supplementary material to our research article entitled "Impact of CD14++CD16+ monocytes on coronary plaque vulnerability assessed by optical coherence tomography in coronary artery disease patients" [1]. This article contains the data of study population, diagnostic ability of CD14++CD16+ monocytes to identify thin-cap fibroatheromas, and association between laboratory variables and plaque properties.2018年06月, Data in brief, 18, 172 - 175, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Residual symptoms after pulmonary endarterectomy (PEA) remain as the clinical issues to be solved. Additional balloon pulmonary angioplasty (BPA) after PEA showed its efficacy with symptoms in a case series, although long-term spontaneous recovery of exercise ability after PEA was also reported. However, no studies have validated the clinical efficacy of additional BPA by directly comparing PEA with and without BPA. The aim of this study was to retrospectively evaluate the efficacy of additional BPA as a sequential hybrid therapy for chronic thromboembolic pulmonary hypertension after PEA. METHODS AND RESULTS: Among 44 patients with chronic thromboembolic pulmonary hypertension, 20 patients had residual symptoms after PEA. Of those, 10 patients underwent additional BPA (hybrid group) and were compared with the other 10 patients, who were followed up without BPA (PEA group). The period from PEA to additional BPA was 7.3±2.3 months. In hybrid group, mean pulmonary arterial pressure was significantly improved by PEA (40.6±1.8 to 26.9±3.1 mm Hg, P=0.001) and improved further (to 16.7±1.8 mm Hg, P=0.002) with additional BPA, which resulted in remarkable improvement in World Health Organization (WHO) functional class (pre- to post-BPA: class I/II/III/IV, 0/5/4/1 to 7/3/0/0; P<0.001). Compared with the PEA group at follow-up, the hybrid group achieved better mean pulmonary arterial pressure (18.7±1.7 versus 30.2±3.2 mm Hg, P=0.008), WHO functional class (class I/II/III/IV, 7/3/0/0 versus 0/8/2/0; P=0.001), and 6-minute walking distance (429±38 versus 319±22 m, P=0.028). CONCLUSIONS: A sequential hybrid strategy improved residual symptoms and exercise capacity compared with single-PEA therapy.2018年06月, J Am Heart Assoc., 7(13) (13), 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2018年06月, JACC Cardiovasc Interv., 11(11) (11), 1114 - 1116, 英語Early Introduction of Pulmonary Endarterectomy or Balloon Pulmonary Angioplasty Contributes to Better Health-Related Quality of Life in Patients With Chronic Thromboembolic Pulmonary Hypertension.[査読有り]研究論文（学術雑誌）
- 2018年04月, EuroIntervention., 英語Lumen Boundaries Extracted from Coronary Computed Tomography Angiography on Computed Fractional Flow Reserve (FFRCT): Validation with Optical Coherence Tomography.[査読有り]研究論文（学術雑誌）
- EuroPCR, 2018年04月, EuroIntervention, 13(17) (17), 2060 - 2068, 英語[査読有り]研究論文（国際会議プロシーディングス）
- 2018年03月, JACC Cardiovasc Imaging., 英語Identification of High-Risk Plaques Destined to Cause Acute Coronary Syndrome Using Coronary Computed Tomographic Angiography and Computational Fluid Dynamics.[査読有り]研究論文（学術雑誌）
- OBJECTIVES: The closure of atrial septal defect (ASD) results in normalized left ventricular (LV) and right ventricular (RV) geometry, and can increase LV stroke volume (LVSV), but the parameters associated with this increase after the closure of ASD remain uncertain. METHODS: Seventy ASD patients, who underwent transcatheter closure, were studied. Their mean age was 57.80 ± 16.88 years, 42 (60%) were female, and LV ejection fraction (LVEF) was 66.76% ± 7.91% (all ≥55%). Transthoracic echocardiography was performed before and 3 months after the procedure. Global longitudinal strain (GLS) was determined as the average peak speckle tracking strain of 18 segments from the 3 standard apical views, LV dispersion was defined as standard deviation of time-to-peak strain from the same views, and RV systolic function was calculated by averaging the 3-regional peak speckle tracking longitudinal strains from the RV free wall. A significant relative increase in LVSV between before and 3 months after the closure was defined as ∆LVSV ≥15%. Twenty age-, gender-, and LVEF-matched controls served as the control group. RESULTS: Global longitudinal strain (GLS) and RV free wall strain were similar for ASD patients and controls, but LV dispersion in ASD patients was significantly larger. Global longitudinal strain (GLS) remained unchanged after transcatheter closure, whereas RV free wall strain and LV dispersion decreased significantly. An important finding of the multivariate logistic regression analysis showed that ∆LV dispersion was the only independent determinant of increased LVSV after the closure (OR 1.023; 95% CI 1.001-1.046; P < .01). CONCLUSIONS: The assessment of LV dispersion may well have clinical implications for better management of ASD patients after transcatheter closure.2018年02月, Echocardiography (Mount Kisco, N.Y.), 35(2) (2), 218 - 226, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND AND AIMS: This study examined the impact of CD14++CD16+ monocytes on coronary plaque vulnerability, as assessed by optical coherence tomography (OCT), and investigated their association with daily glucose fluctuation. Although increased CD14++CD16+ monocyte levels have been reported to increase cardiovascular events, their impact on coronary plaque vulnerability in coronary artery disease (CAD) patients with or without diabetes mellitus (DM) remains unclear. METHODS: This prospective observational study included 50 consecutive patients with CAD, receiving lipid-lowering therapy and undergoing coronary angiography and OCT. Patients were divided into 3 tertiles according to the CD14++CD16+ monocyte percentages assessed by flow cytometry. Standard OCT parameters were assessed for 97 angiographically intermediate lesions (diameter stenosis: 30-70%). Daily glucose fluctuation was analyzed by measuring the mean amplitude of glycemic excursion (MAGE). RESULTS: CD14++CD16+ monocytes negatively correlated with fibrous cap thickness (r = -0.508, p < 0.01). The presence of thin-cap fibroatheroma (TCFA) was increased stepwise according to the tertile of CD14++CD16+ monocytes (0 [tertile 1] vs. 5 [tertile 2] vs. 10 [tertile 3], p < 0.01). CD14++CD16+ monocytes were a significant determinant of TCFA (OR 1.279, p = 0.001). In non-DM patients, a significant relationship was found between CD14++CD16+ monocytes and MAGE (r = 0.477, p = 0.018). CONCLUSIONS: CD14++CD16+ monocytes were associated with coronary plaque vulnerability in CAD patients with well-regulated lipid levels both in DM and non-DM patients. Cross-talk between glucose fluctuation and CD14++CD16+ monocytes may enhance plaque vulnerability, particularly in non-DM patients. CD14++CD16+ monocytes could be a possible therapeutic target for coronary plaque stabilization.2018年02月, Atherosclerosis, 269, 245 - 251, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Elsevier Inc., 2018年01月, JACC: Cardiovascular Imaging, 11(1) (1), 111 - 123, 英語[査読有り]研究論文（学術雑誌）
- The use of cobalt-chromium everolimus-eluting stents (CoCr-EES) for ST-segment elevation myocardial infarction (STEMI) reduces the incidence of stent thrombosis compared with bare metal stents, and a substantial difference is apparent in the initial 2 weeks. However, vascular behavior during this early period remains unclear. This was a prospective study (MECHANISM-AMI-2W) to investigate early vascular responses in STEMI patients immediately after CoCr-EES implantation and at 2-week follow-up using frequency domain-optical coherence tomography (FD-OCT). The study enrolled 52 patients (age 63.7 ± 11.7 years, male 85.0%), of whom 44 patients were available for complete serial FD-OCT analyses. Both % uncovered struts and % malapposed struts were improved at 2-week follow-up (63 ± 20 vs. 21 ± 14%, p < 0.0001 and 7.3 ± 9.0 vs. 4.7 ± 5.9%, p = 0.005, respectively). Thrombus was decreased, with significant changes in longitudinal length to stent (28.8 ± 27.7 vs. 18.1 ± 20.2%, p = 0.0001) and maximal area (0.93 ± 0.84 vs. 0.65 ± 0.63 mm2, p = 0.034). As a result, the average lumen area was significantly larger at 2 weeks (6.49 ± 1.82 vs. 6.71 ± 1.89 mm2, p = 0.048, respectively). The number of dissection flaps was lower (0.86 ± 1.11 vs. 0.52 ± 0.90%, p = 0.024). In conclusion, this study showed early vascular responses to CoCr-EES for STEMI lesions-including a significant reduction of thrombus-that resulted in lumen enlargement, earlier progression of strut coverage, and improvements in strut apposition and dissection. The combination of these factors may therefore be responsible for the safety of CoCr-EES within the initial 2 weeks.2018年01月, Cardiovasc Interv Ther., 34(1) (1), 14 - 24, 英語, 国内誌[査読有り]研究論文（学術雑誌）
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- Springer Tokyo, 2016年01月, Cardiovascular Intervention and Therapeutics, 31(1) (1), 1 - 12, 英語[査読有り]研究論文（学術雑誌）
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- 2015年11月, Int J Cardiol Heart Vasc., 英語High perfusion pressure as predictor of reperfusion pulmonary injury after balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension.[査読有り]研究論文（学術雑誌）
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- 2014年, Circulation Journal, 78(1) (1), 92 - 100, 英語[査読有り]研究論文（学術雑誌）
- 2013年11月, THROMBOSIS RESEARCH, 132(5) (5), 558 - 564, 英語[査読有り]研究論文（学術雑誌）
- 2013年10月, JACC: Cardiovascular Imaging, 6(10) (10), 1121 - 1123, 英語[査読有り]研究論文（学術雑誌）
- 2013年09月, 日本心臓病学会誌, 8(Suppl.I) (Suppl.I), 389, 日本語慢性血栓塞栓性肺高血圧症に対する肺動脈カテーテル治療と血栓内膜摘除術の比較研究論文（その他学術会議資料等）
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- 2013年09月, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 14(9) (9), 865 - 875, 英語[査読有り]研究論文（学術雑誌）
- 2013年09月, INTERNATIONAL JOURNAL OF CARDIOLOGY, 168(2) (2), 960 - 966, 英語[査読有り]研究論文（学術雑誌）
- 2013年08月, International Journal of Cardiology, 167(4) (4), 1591 - 1596, 英語[査読有り]研究論文（学術雑誌）
- 2013年08月, Vascular Disease Management, 10(8) (8), E142 - E151, 英語The comorbidity of peripheral arterial disease attenuates complications during primary percutaneous coronary intervention in st-elevation myocardial infarction研究論文（学術雑誌）
- 2013年05月, 日本心血管インターベンション治療学会誌, 5(Suppl.I) (Suppl.I), 466, 日本語各種血管イメージングの基礎 機能的評価と形態学的評価研究論文（その他学術会議資料等）
- 2013年05月, CIRCULATION JOURNAL, 77(5) (5), 1193 - 1201, 英語[査読有り]研究論文（学術雑誌）
- 2013年02月, 日本内科学会雑誌, 102(Suppl.) (Suppl.), 161, 日本語第2世代Everolimus溶出性ステント留置後の血管治癒過程関する検討研究論文（その他学術会議資料等）
- 2013年01月, Coronary Intervention, 9(1号) (1号), 32 - 38, 日本語【DES留置後の抗血小板薬の使い方】 ステント構造から見たDAPTの期間[査読有り]研究論文（学術雑誌）
- 2013年, Circulation Journal, 77(3) (3), 652 - 660, 英語[査読有り]研究論文（学術雑誌）
- 2012年12月, CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 5(6) (6), 763 - 771, 英語[査読有り]研究論文（学術雑誌）
- 2012年10月, CIRCULATION JOURNAL, 76(10) (10), 2348 - 2355, 英語[査読有り]研究論文（学術雑誌）
- 社団法人日本循環器学会, 2012年09月, 循環器専門医, 20(2号) (2号), 267 - 273, 日本語[査読有り]研究論文（学術雑誌）
- 2012年08月, CIRCULATION JOURNAL, 76(8) (8), 1880 - 1888, 英語[査読有り]研究論文（学術雑誌）
- 2012年06月, 日本心血管インターベンション治療学会誌, 4(Suppl.2) (Suppl.2), 418, 日本語最新心血管イメージング ここまで分かる、見える診療支援画像 光干渉断層撮影(OCT)画像の診かた[査読有り]研究論文（学術雑誌）
- 2012年06月, 日本心臓病学会誌, 7(2号) (2号), 129 - 135, 日本語血管内イメージングの最前線 OCTによる薬剤溶出性ステントの評価[査読有り]研究論文（学術雑誌）
- 2012年05月, INTERNATIONAL JOURNAL OF CARDIOLOGY, 157(1) (1), 38 - 42, 英語[査読有り]研究論文（学術雑誌）
- 2012年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E206[査読有り]
- 2012年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(12) (12), 1058 - 1072, 英語[査読有り]研究論文（学術雑誌）
- 2011年11月, JOURNAL OF CARDIOLOGY, 58(3) (3), 245 - 252, 英語[査読有り]研究論文（学術雑誌）
- 2011年10月, AMERICAN JOURNAL OF CARDIOLOGY, 108(7) (7), 912 - 917, 英語[査読有り]研究論文（学術雑誌）
- 2011年09月, Cardiovascular Engineering and Technology, 2(3) (3), 212 - 227, 英語[査読有り]研究論文（学術雑誌）
- 2011年09月, HEART, 97(17) (17), 1379 - 1384, 英語[査読有り]研究論文（学術雑誌）
- 2011年07月, Circ J., 75(10) (10), 2505 - 7, 英語, 国内誌Ability of optical coherence tomography to visualize the entry port of spontaneous coronary artery dissection.[査読有り]研究論文（学術雑誌）
- 2011年05月, JACC Cardiovasc Interv., 2, 459 - 466, 英語Local determinants of thrombus formation following sirolimus-eluting stent implantation assessed by optical coherence tomography.[査読有り]研究論文（学術雑誌）
- 2011年04月, Circ Cardiovasc Interv., 4(2) (2), 146 - U69, 英語[査読有り]研究論文（学術雑誌）
- 2011年03月, Journal of Invasive Cardiology, 23(3) (3), E49 - E50, 英語Ruptured-plaque-like appearance of restenotic tissue following sirolimus-eluting stent implantation: An optical coherence tomography case study[査読有り]研究論文（学術雑誌）
- 2010年11月, CIRCULATION, 122(21) (21)Impact of Diabetes Mellitus on Vessel Response in the Drug-Eluting Stent Era: Pooled Volumetric Intravascular Ultrasound Analysis[査読有り]
- 2010年11月, CIRCULATION, 122(21) (21)Impact of Mechanical Factor and Biologic Response on Severe In-Stent Lumen Narrowing in Currently Approved Drug-Eluting Stents[査読有り]
- 2010年11月, CIRCULATION, 122(21) (21), 英語CCR2 Antagonist Inhibits Neointimal Proliferation Post CoronaryStent Deployment[査読有り]
- 2010年11月, JOURNAL OF INVASIVE CARDIOLOGY, 22(11) (11), 541 - 545, 英語The Ability of Optical Coherence Tomography to Monitor Percutaneous Coronary Intervention: Detailed Comparison with Intravascular Ultrasound[査読有り]研究論文（学術雑誌）
- 2010年11月, INTERNATIONAL JOURNAL OF CARDIOLOGY, 145(1) (1), 125 - 126, 英語研究論文（学術雑誌）
- 2010年09月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(13) (13), B15Impact of Lumen Narrowing Within Drug-Eluting Stents and Bare-Metal Stents on Downstream Vessel Segments[査読有り]
- 2010年09月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(13) (13), B15Vessel Response to Drug-Eluting Stents in PatientsVVith vs. Without Diabetes Mellitus: Pooled Volumetric Intravascular Ultrasound Analysis[査読有り]
- 2010年09月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(13) (13), B91 - B91, 英語CCR2 Antagonist Inhibits Neointimal Proliferation Post Coronary Stent Deployment[査読有り]
- 2010年09月, INTERNATIONAL JOURNAL OF CARDIOLOGY, 144(1) (1), 132 - 134, 英語[査読有り]研究論文（学術雑誌）
- 2010年09月, INTERNATIONAL JOURNAL OF CARDIOLOGY, 144(1) (1), 132 - 134, 英語研究論文（学術雑誌）
- 2010年08月, AMERICAN JOURNAL OF CARDIOLOGY, 106(4) (4), 492 - 497, 英語研究論文（学術雑誌）
- 2010年07月, AMERICAN JOURNAL OF CARDIOLOGY, 106(1) (1), 13 - 17, 英語研究論文（学術雑誌）
- 2010年07月, INTERNATIONAL JOURNAL OF CARDIOLOGY, 142(3) (3), 250 - 256, 英語[査読有り]研究論文（学術雑誌）
- 2010年06月, CIRCULATION JOURNAL, 74(6) (6), 1257 - 1259, 英語研究論文（学術雑誌）
- 2010年06月, EUROINTERVENTION, 6(2) (2), 195 - 205, 英語A randomised comparison of novolimus-eluting and zotarolimus-eluting coronary stents: 9-month follow-up results of the EXCELLA II study研究論文（学術雑誌）
- 2010年05月, CIRCULATION JOURNAL, 74(5) (5), 1023 - 1025, 英語研究論文（学術雑誌）
- 2010年05月, CIRCULATION JOURNAL, 74(5) (5), 903 - 908, 英語[査読有り]研究論文（学術雑誌）
- 2009年12月, JOURNAL OF INVASIVE CARDIOLOGY, 21(12) (12), 613 - 617, 英語Preprocedural Inflammation Does Not Affect Neointimal Hyperplasia following Everolimus-Eluting Stent Implantation[査読有り]研究論文（学術雑誌）
- 2009年09月, AMERICAN JOURNAL OF CARDIOLOGY, 104(6A) (6A), 63DSerial Arterial Response to a Novel Drug-Eluting Stent with Novolimus, a Sirolimus Metabolite: IVUS Insights from the First Human Experience[査読有り]
- 2009年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(10) (10), A9Relative Dose and Vascular Response After Drug-Eluting Stent Implantation: A Dosimetric 3D-Intravascular Ultrasound Study[査読有り]
- 2009年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(10) (10), A15Intravascular Ultrasound Analysis of Vessel Response in Acute Coronary Syndrome Treated with Zotarolimus-Eluting Stents[査読有り]
- 2009年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(10) (10), A94Gender Difference in Vessel Response in Coronary Artery Disease Treated with Zotarolimus-Eluting Stents[査読有り]
- 2009年02月, CIRCULATION JOURNAL, 73(2) (2), 343 - 351, 英語Pioglitazone Reduces the Necrotic-Core Component in Coronary Plaque in Association With Enhanced Plasma Adiponectin in Patients With Type 2 Diabetes Mellitus[査読有り]研究論文（学術雑誌）
- 2008年10月, CIRCULATION, 118(18) (18), S1044SPIRIT III Japan: Eight-Month IVUS Analysis of Everolimus-Elurting Stent Compared to the US Arm[査読有り]
- 2008年10月, AMERICAN JOURNAL OF CARDIOLOGY, 102(8A) (8A), 197IIncidence of Diffuse and Focal Chronic Stent Recoil after Implantation of Current Generation Bare-metal and Drug-eluting Stents[査読有り]
- 2008年10月, AMERICAN JOURNAL OF CARDIOLOGY, 102(8A) (8A), 138IIVUS Analysis in the SPIRIT III Japan Treated with XIENCE (TM) V Everolimus-Eluting Stent Compared to the SPIRIT III US Arm[査読有り]
- 2008年10月, CIRCULATION, 118(18) (18), S1051 - S1051, 英語Impact of Pre-procedural C-reactive Protein on Intravascular Ultrasound Parameters following Everolimus-eluting Stent Implantation: Results from the SPIRIT III Trial[査読有り]
- 2008年05月, EUROPEAN HEART JOURNAL, 29(9) (9), 1136 - 1146, 英語[査読有り]研究論文（学術雑誌）
- 2008年01月, AMERICAN JOURNAL OF CARDIOLOGY, 101(1) (1), 1 - 7, 英語[査読有り]研究論文（学術雑誌）
- 2007年10月, AMERICAN HEART JOURNAL, 154(4) (4), 英語[査読有り]研究論文（学術雑誌）
- 2007年04月, EUROPEAN HEART JOURNAL, 28(8) (8), 961 - 967, 英語[査読有り]研究論文（学術雑誌）
- 2007年01月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 49(2) (2), 250 - 260, 英語[査読有り]研究論文（学術雑誌）
- 2006年11月, CIRCULATION JOURNAL, 70(11) (11), 1515 - 1519, 英語Persistent malapposition after implantation of sirolimus-eluting stent into intramural coronary hematoma - Optical coherence tomography observations[査読有り]研究論文（学術雑誌）
- 2006年09月, CIRCULATION JOURNAL, 70(9) (9), 1164 - 1168, 英語Impedance cardiography for cardiac output estimation - Reliability of wrist-to-ankle electrode configuration[査読有り]研究論文（学術雑誌）
- 2006年04月, EUROPEAN HEART JOURNAL, 27(7) (7), 832 - 838, 英語[査読有り]研究論文（学術雑誌）
- 【背景と目的】冠動脈ステント留置後遠隔期再狭窄には,拡張後のステント断面積,ステント外の残存プラーク量が影響するとされる.今回,血管内超音波(IVUS)ガイド下にbare metal Bx velocityステントの留置を行い,病変部動脈リモデリングとの関連を検討した.公益財団法人 日本心臓財団, 2006年03月, 心臓, 38巻, 3号, pp.246-251(3) (3), 246 - 251, 日本語
【方法】対象は,同ステントの留置前後に良好なIVUS画像が得られた62病変(53症例).経皮的冠動脈形成術(PCI)前に,IVUSにより病変部血管断面積(vessel area:VA)/平均対照部VA>1.0をポジティブリモデリング(PR)群(n=30),≦1.0をnon-PR群(n=32)とし,比較検討した.PCI前,ステント留置後の病変部のVA(mm2),内腔面積(lumenarea:LA)(mm2),プラーク面積率(%plaquearea:%PA=VA-LA/VA)を計測し,PCI前後,遠隔期(6±1カ月後)に定量的冠動脈造影(QCA)を行い,病変部最小血管径(MLD)(mm),径狭窄率(%DS),病変長(LL)(mm)を計測,遠隔期%DS>50%を再狭窄とした.PR群について,ステント拡張後残存%PAの中央値(47%)で2群に分け,再狭窄率を比較した.
【結果】使用ステント径,長さ,最大拡張圧,最終バルーン径は両群間に差はなかった.PR群,non-PR群ともに,術後同等のステント断面積が得られたが,慢性期の内径損失がPR群で高い傾向にあり,再狭窄率が高かった(52%vs25%;p<0.05).PR群において残存%PAの少ない例(%PA:40.9±5.3%)と多い例(54.2±9.0%)の間に再狭窄率に差はなかった(46%vs42%).
【結語】冠動脈病変部血管のポジティブリモデリングは,Bx velocityステント留置後の,遠隔期再狭窄に寄与すると考えられた.[査読有り]研究論文（学術雑誌） - 2006年, Journal of Cardiology, 48(3) (3), 141 - 150, 日本語Relationship between high sensitive c-reactive protein and coronary plaque component in patients with acute coronary syndrome: virtual histology TM study[査読有り]研究論文（学術雑誌）
- 2006年01月, 心臓, 38巻, 1号, pp.71-74, 日本語[査読有り]研究論文（学術雑誌）
- 2005年10月, Journal of Cardiology, 46(4) (4), 161 - 164, 英語Beneficial effects of human atrial natriuretic peptide on renal function in a patient with repeated coronary interventions: A case report[査読有り]研究論文（学術雑誌）
- 2004年06月, Therapeutic Research, 25巻, 6号, pp. 1214-1216, 日本語当院における急性肺塞栓症の治療経験,外科的塞栓摘出術の有用性[査読有り]研究論文（学術雑誌）
- 2024年, 日本循環器学会学術集会(Web), 88th第二世代薬物溶出ステントによる経皮的冠動脈インターベンション後の臨床転帰に対する冠動脈周囲脂肪組織減衰の影響【JST機械翻訳】|||
- 2023年, 日本成人先天性心疾患学会雑誌(Web), 12(1) (1)BT短絡術後遠隔期の血栓性閉塞に対して経皮的ステント留置術が有効であった一例
- 2023年, 日本循環器学会学術集会(Web), 87th経カテーテル大動脈弁置換術を受けた重度大動脈弁狭窄症患者におけるニトログリセリン非使用FFRCTに基づく生理的評価の診断精度
- 2023年, 日本腫瘍循環器学会学術集会抄録集(Web), 6thがんの既往と第2世代ステント血栓症との関連~REAL-STレジストリ研究より~
- (一社)日本動脈硬化学会, 2019年07月, 日本動脈硬化学会総会プログラム・抄録集, 51回, 2 - 3, 日本語日本人において血清トランス脂肪酸濃度の上昇は経皮的冠動脈インターベンション後の再血行再建術発生の独立したリスク因子となる
- (一社)日本循環器学会, 2019年03月, 日本循環器学会学術集会抄録集, 83回, PJ100 - 3, 英語HDL機能性の新しい指標であるコレステロール取り込み能とコレステロール排出能の冠動脈プラーク特性に関連した比較(Comparison of Cholesterol Uptake Capacity, a Novel Indicator for HDL-functionality, and Cholesterol Efflux Capacity in Association with Coronary Plaque Properties)
- 2018年11月06日, CIRCULATION, 138, 英語Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, vs. Cholesterol Efflux Capacity in Association With Coronary Plaque Lipid Burden.研究発表ペーパー・要旨（国際会議）
- 2017年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B331 - B331, 英語The clinical impact of daily glucose fluctuation on cardiovascular events in patients with stable angina pectoris pretreated with lipid-lowering therapy研究発表ペーパー・要旨（国際会議）
- 2017年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B286 - B286, 英語Coronary Risk Factors Associated with OCT Macrophage Images and their Response After CoCr Everolimus-Eluting Stent Implantation in Patients with Stable Coronary Artery Disease: Subanalysis of the MECHANISM-Elective study研究発表ペーパー・要旨（国際会議）
- 2017年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B186 - B186, 英語High Wall Shear Stress was Strongly Associated with Plaque Vulnerability in Computational Fluid Dynamics with Combined Optical Coherence Tomography and Heartflow FFRCT Simulation研究発表ペーパー・要旨（国際会議）
- 2017年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B42 - B42, 英語Different tissue morphology of in-stent restenosis in hemodialysis patient compared with non-hemodialysis patients: a prospective multicenter optical coherence tomography registry研究発表ペーパー・要旨（国際会議）
- 2017年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B220 - B220, 英語The combination of rosuvastatin (10mg) and eicosapentaenoic acid (1800mg) improved native coronary plaques > 5.7 years after stent implantation研究発表ペーパー・要旨（国際会議）
- 2017年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B96 - B96, 英語Vascular healing response to biodegradable-polymer sirolimus-eluting stent, UltimasterTM, in comparison with durable-polymer everolimus-eluting stent, XienceTM/PromusTM, assessed by optical coherence tomography and angioscopy at 10 months研究発表ペーパー・要旨（国際会議）
- (一社)日本循環器学会, 2017年03月, 日本循環器学会学術集会抄録集, 81回, PJ - 386, 英語大動脈弁石灰化の密度は大動脈弁口面積に依存することなく大動脈弁狭窄の血行動態的重症度を予測する(Aortic Valve Calcification Density Predicts the Hemodynamic Severity of Aortic Stenosis Independently of Aortic Valve Area)
- 2017年02月, JACC-CARDIOVASCULAR INTERVENTIONS, 10(3) (3), S30 - S30, 英語Conformability and Wall Shear Stress Assessment Following Deployment of Resolute Integrity Zotarolimus-Eluting Stent and the XIENCE Xpedition Everolimus-Eluting Stent in Angulated Vessels: An Interim Analysis of the SHEAR-STENT Randomized Controlled Study研究発表ペーパー・要旨（国際会議）
- 2017年, 日本循環器学会学術集会(Web), 81st急性心筋梗塞および安定冠動脈疾患患者におけるCoCr-EESの3か月移植後の異なる応答【JST・京大機械翻訳】|||
- 医歯薬出版, 2016年11月05日, 医学のあゆみ, 259(6) (6), 631 - 637, 日本語冠動脈疾患領域におけるOCTの現状と可能性 (第1土曜特集 虚血性心疾患UPDATE) -- (虚血性心疾患の診断の進歩)
- 2016年11月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B37 - B37, 英語Efficacy of aggressive balloon pulmonary angioplasty on chronic thromboembolic pulmonary hypertension beyond normalized mean pulmonary arterial pressure研究発表ペーパー・要旨（国際会議）
- 2016年11月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B36 - B37, 英語Efficacy and safety of sequential hybrid therapy with pulmonary endarterectomy and additional balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension研究発表ペーパー・要旨（国際会議）
- 2016年11月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B136 - B136, 英語Impaired HDL uptake capacity which measure HDL functionality may associate with target lesion revascularization through provoking neoatherosclerosis formation after stent implantation研究発表ペーパー・要旨（国際会議）
- 2016年11月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B239 - B240, 英語Potent effect of prasugrel on acute phase resolution of intra-stent tissue after percutaneous intervention to acute coronary syndrome研究発表ペーパー・要旨（国際会議）
- 2016年11月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B227 - B227, 英語Early vascular responses to everolimus-eluting cobalt-chronium stent for the treatment of ST-elevation acute myocardial infarction: the results of the MECHANISM-AMI study 3-months OCT follow-up cohort研究発表ペーパー・要旨（国際会議）
- 2016年11月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B243 - B243, 英語Why does thin-cap fibroatheroma cluster in the proximal segment in left anterior coronary artery, but are evenly distributed throughout the entire right coronary artery? Results from computational fluid dynamics simulation by CT-FFR研究発表ペーパー・要旨（国際会議）
- 2016年08月, EUROPEAN HEART JOURNAL, 37, 389 - 389, 英語Impact of daily glucose fluctuation on progression of luminal narrowing in stable coronary artery disease patients pretreated with lipid-lowering therapy研究発表ペーパー・要旨（国際会議）
- 2016年08月, EUROPEAN HEART JOURNAL, 37, 387 - 387, 英語Early vascular responses to everolimus-eluting cobalt-chromium stent for the treatment of stable coronary artery disease: The results of MECHANISM-Elective 1 and 3 months OCT follow-up cohort研究発表ペーパー・要旨（国際会議）
- 2016年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 319 - 319, 英語EVALUATION OF LOCAL HEMODYNAMIC FORCES ACTING ON PLAQUE MAY HELP PREDICT PLAQUE VULNERABILITY: LESSONS FROM COMBINED ANALYSIS OF OPTICAL COHERENCE TOMOGRAPHY AND COMPUTATIONAL FLUID DYNAMICS SIMULATION研究発表ペーパー・要旨（国際会議）
- 2016年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 315 - 315, 英語IMPACT OF PRECISION OF LUMEN BOUNDARY EXTRACTED FROM CORONARY CT ON FFRCT: VALIDATION WITH OCT研究発表ペーパー・要旨（国際会議）
- 2016年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 361 - 361, 英語THE IMPACT OF SERUM TRANS FATTY ACIDS CONCENTRATION ON PLAQUE VULNERABILITY IN PATIENTS WITH CORONARY ARTERY DISEASE UNDER MANAGEMENT OF CONVENTIONAL RISK FACTORS: ASSESSMENT VIA OPTICAL COHERENCE TOMOGRAPHY研究発表ペーパー・要旨（国際会議）
- 2016年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 365 - 365, 英語INTRA-STENT THROMBUS FORMATION FOLLOWING BIOLIMUS A-9 ELUTING STENT IMPLANTATION IN PATIENTS WITH SHORTER AND PROLONGED DUAL ANTI-PLATELET THERAPY: OPTICAL COHERENCE TOMOGRAPHY SUB-STUDY OF NIPPON TRIAL研究発表ペーパー・要旨（国際会議）
- 2016年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 1755 - 1755, 英語IMPACT OF WALL SHEAR STRESS AND AXIAL PLAQUE STRESS ON CORONARY PLAQUE INITIATION AND PROGRESSION研究発表ペーパー・要旨（国際会議）
- 2016年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 935 - 935, 英語INVESTIGATION OF HEMODYNAMIC CHANGES DURING BALLOON OCCLUSION TEST FOR PERCUTANEOUS ATRIAL SEPTAL DEFECT CLOSURE研究発表ペーパー・要旨（国際会議）
- 2016年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 1772 - 1772, 英語CORRELATION OF WALL SHEAR STRESS AND AXIAL PLAQUE STRESS BETWEEN MODELS DERIVED FROM CT AND OCT DATA研究発表ペーパー・要旨（国際会議）
- 2016年, 日本循環器学会近畿地方会(Web), 122nd脂質降下療法を受けている安定狭心症における冠動脈病変の進行に対して血糖変動が及ぼす影響についての検討
- 2015年11月, Coronary Intervention, 11(6号) (6号), 96 - 102, 日本語【冠動脈イメージングを極める-侵襲的から非侵襲的方法-】 冠動脈病変を治療する イメージングガイドインターベンションを極める OCTガイドPCI記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2015年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B21 - B22, 英語Early vascular responses to everolimus-eluting cobalt-chromium stent for the treatment of stable coronary artery disease: The results of MECHANISM-Elective 1-month OCT follow-up cohort研究発表ペーパー・要旨（国際会議）
- 2015年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B140 - B141, 英語Optical coherence tomographic evaluation of very acute change of coronary stent implanted in acute coronary syndrome patients研究発表ペーパー・要旨（国際会議）
- 2015年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B19 - B20, 英語The Impact of Plaque Morphology and Malapposition Area on Late Phase Stent Malapposition: Insight From Optimal Coherence Tomography Sub-study in PRASFIT Elective研究発表ペーパー・要旨（国際会議）
- 2015年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B134 - B134, 英語Accuracy of lumen boundary extracted from coronary CTA for calcified and noncalcified plaques assessed using OCT data研究発表ペーパー・要旨（国際会議）
- 2015年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B138 - B138, 英語Impact of Daily Glucose Fluctuation on Vessel Healing after 2nd Generation Drug-eluting Stent Implantation Assessed by Continuous Glucose Monitoring and Optical Coherence Tomography研究発表ペーパー・要旨（国際会議）
- 2015年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B142 - B142, 英語Early vascular responses to everolimus-eluting cobalt-chromium stent for the treatment of ST-elevation acute myocardial infarction: the results of the MECHANISM-AMI Study 2-week OCT follow-up cohort研究発表ペーパー・要旨（国際会議）
- 2015年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B146 - B146, 英語Combined use of intravascular ultrasound and optical coherence tomography during percutaneous coronary intervention may reduce target lesion revascularization after percutaneous coronary intervention研究発表ペーパー・要旨（国際会議）
- 2015年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65(10) (10), A1737 - A1737, 英語MECHANISM OF LUMINAL WIDENING AND THE CORRECTION OF PLAQUE- AND CARINA-SHIFT AT SIDE BRANCH OSTIUM BY KISSING BALLOON INFLATION FOR CORONARY BIFURCATION LESIONS: VOLUMETRIC INTRAVASCULAR ULTRASOUND ANALYSIS研究発表ペーパー・要旨（国際会議）
- 2015年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65(10) (10), A1838 - A1838, 英語IMPACT OF DIABETES MELLITUS ON VESSEL GEOMETRY AND THE RESPONSE TO FINAL KISSING INFLATION FOLLOWING SINGLE STENTING FOR CORONARY BIFURCATION: ANALYSIS OF VOLUMETRIC INTRAVASCULAR ULTRASOUND AND OPTICAL COHERENCE TOMOGRAPY研究発表ペーパー・要旨（国際会議）
- 2015年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65(10) (10), A1851 - A1851, 英語ASSOCIATION BETWEEN DAILY GLUCOSE FLUCTUATION AND CORONARY PLAQUE PROPERTIES IN PATIENTS RECEIVING LIPID-LOWERING THERAPY ASSESSED BY CONTINUOUS GLUCOSE MONITORING AND OPTICAL COHERENCE TOMOGRAPHY: A PROSPECTIVE OBSERVATIONAL STUDY研究発表ペーパー・要旨（国際会議）
- 2015年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65(10) (10), A1939 - A1939, 英語BENEFICIAL EFFECT OF PLATELET INHIBITION AGAINST PERI-PROCEDURAL MYOCARDIAL INFARCTION DUE TO INTRA-STENT THROMBUS PENETRATION: OPTICAL COHERENCE TOMOGRAPHY SUB-ANALYSIS IN PRASFIT ELECTIVE研究発表ペーパー・要旨（国際会議）
- 2014年09月, EUROPEAN HEART JOURNAL, 35, 208 - 208, 英語Either balloon pulmonary angioplasty or surgical pulmonary endarterectomy can cover most of patients with chronic thromboembolic pulmonary hypertension as treatment option研究発表ペーパー・要旨（国際会議）
- 2014年09月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 64(11) (11), B115 - B116, 英語Serial Optical Coherence Tomography Evaluation 6-, 12-and 24-month Follow-up after Nobori Biolimus A9-eluting Stent Implantation研究発表ペーパー・要旨（国際会議）
- 2014年08月09日, Heart View, 18(8) (8), 852 - 860, 日本語新時代を迎えた冠動脈インターベンション 10 OCT/OFDIガイドPCIの現状と展望
- 2014年07月, 日本心血管インターベンション治療学会抄録集 23回, CPD4 - 3, 日本語モダリティーを駆使してイメージング巧者になる Tips & Tricks FD-OCTの臨床活用術会議報告等
- 2014年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 63(12) (12), A1797 - A1797, 英語LONG-TERM CLINICAL IMPACT OF THIN-CAP FIBROATHEROMA ASSESSED BY OPTICAL COHERENCE TOMOGRAPHY AND VIRTUAL HISTOLOGY INTRAVASCULAR ULTRASOUND ANALYSIS研究発表ペーパー・要旨（国際会議）
- 2014年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 63(12) (12), A1795 - A1795, 英語IMPACT OF DAILY GLUCOSE FLUCTUATION ON CORONARY PLAQUE VULNERABILITY IN PATIENTS PRETREATED WITH LIPID LOWERING THERAPY研究発表ペーパー・要旨（国際会議）
- 2014年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 63(12) (12), A1161 - A1161, 英語ASSESSMENT OF PLAQUE CHARACTERIZATION ON CORONARY CT ANGIOGRAPHY FOR IDENTIFICATION OF HIGH-RISK CORONARY ARTERY LESIONS: A DIRECT COMPARISON TO OPTICAL COHERENCE TOMOGRAPHY研究発表ペーパー・要旨（国際会議）
- 2014年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 63(12) (12), A1913 - A1913, 英語INTRAVASCULAR ULTRASOUND ASSESSMENT OF SIDE BRANCH OSTIUM AFTER A CROSSOVER STENTING WITH FINAL KISSING BALLOON INFLATION IN CORONARY BIFURCATION LESION研究発表ペーパー・要旨（国際会議）
- 2014年04月, The Lipid, 25(2号) (2号), 170 - 174, 日本語脂質代謝異常症への多角的アプローチ エベロリムス溶出性ステント留置後の血管治癒過程に関する検討[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2013年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 62(18) (18), B178 - B178, 英語Impact of Immediate Vessel Reactions to Stent Deployment on Periprocedural Troponin Leakage and Mid-term Vascular Healing: Serial Optical Coherence Tomography Study after Everolimus-eluting Stent Implantation研究発表ペーパー・要旨（国際会議）
- 2013年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 62(18) (18), B140 - B140, 英語The Impact of Atherogenic Neointima on Long-term Clinical Outcomes: An Observational Study from the Optical Coherence Tomography Registry研究発表ペーパー・要旨（国際会議）
- 2013年09月, 日本心臓病学会誌, 8(Suppl.I) (Suppl.I), 161, 日本語透析患者におけるカテーテル治療戦略 透析患者における薬剤溶出性ステント留置後のoptical coherence tomography所見 透析前後における血小板凝集能との関連について会議報告等
- 2013年08月, EUROPEAN HEART JOURNAL, 34, 155 - 155, 英語Efficacy and safety of balloon pulmonary angioplasty for inoperable patients with peripheral type chronic thromboembolic pulmonary hypertension研究発表ペーパー・要旨（国際会議）
- 2013年08月, EUROPEAN HEART JOURNAL, 34, 50 - 50, 英語Hemodynamic improvement through beneficial vessel reaction following balloon pulmonary angioplasty for distal-type chronic thromboembolic pulmonary hypertension研究発表ペーパー・要旨（国際会議）
- 2013年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 61(10) (10), E1673 - E1673, 英語DIFFERENT TIME COURSE OF NEOATHEROSCLEROSIS DEVELOPMENT IN BARE METAL STENTS, SIROLIMUS-ELUTING STENTS AND PACLITAXEL-ELUTING STENTS研究発表ペーパー・要旨（国際会議）
- 2012年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 60(17) (17), B220 - B220, 英語Efficacy and Safety of Balloon Pulmonary Angioplasty for Peripheral Type Chronic Thromboembolic Pulmonary Hypertension研究発表ペーパー・要旨（国際会議）
- 2012年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 60(17) (17), B191 - B191, 英語Multi Center, Prospective, Randomized, Single Blind, Consecutive Enrollment Evaluation Of Elixir DESyneTM Novolimus-Eluting Coronary Stent System With Durable Polymer To Endeavor Zotarolimus-Eluting Coronary Stent System: 3-Year Clinical and 9-Month Angiographic And IVUS Results: EXCELLA II Study研究発表ペーパー・要旨（国際会議）
- 2012年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 60(17) (17), B83 - B83, 英語Temporal Course of Vessel Healing after Everolimus-eluting Stent Implantation研究発表ペーパー・要旨（国際会議）
- 2012年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 60(17) (17), B220 - B221, 英語Beneficial Vascular Remodeling and Hemodynamic Improvement following Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension研究発表ペーパー・要旨（国際会議）
- 2012年08月, EUROPEAN HEART JOURNAL, 33, 708 - 709, 英語Relationship between optical coherence tomography (OCT), intravascular ultrasound tomography (IVUS) and pressure-derived fractional flow reserve研究発表ペーパー・要旨（国際会議）
- 2012年08月, EUROPEAN HEART JOURNAL, 33, 307 - 307, 英語Paraoxonase-1 (PON1) activity is associated with clopidogrel response and intra-stent thrombus after drug-eluting stent implantation in the CYP2C19 loss-of-function polymorphism carriers研究発表ペーパー・要旨（国際会議）
- 2012年08月, EUROPEAN HEART JOURNAL, 33, 1005 - 1005, 英語Impact of Cytochrome P450 2C19 loss-of-function polymorphism on intra-stent thrombus after sirolimus- and everolimus-eluting stent implantation assessed by angioscopy and optical coherence tomography研究発表ペーパー・要旨（国際会議）
- メディカ出版, 2012年08月, CIRCULATION Up-to-Date, 7(4号) (4号), 387 - 393, 日本語心血管インターベンションのコツとピットフォール 一流術者のココが知りたい OCTを日常のPCIに活かす記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 医学書院, 2012年07月, 呼吸と循環, 60(7号) (7号), 749 - 757, 日本語記事・総説・解説・論説等（学術雑誌）
- 2012年04月, 新薬と臨牀, 61(4号) (4号), 780 - 788, 日本語クロピドグレルにラベプラゾールを併用した薬剤溶出性ステント留置後患者におけるステント内血栓の検討 CYP2C19機能欠失型遺伝子多型の有無別にみたラベプラゾールの影響[査読有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 日本心血管インターベンション治療学会, 2012年03月15日, 日本心血管インターベンション治療学会誌 = Cardiovascular intervention and therapeutics, 4(1) (1), 53 - 57, 日本語留置7ヵ月後に発症した Bare metal stent 血栓症の1症例
- 2012年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E219 - E219, 英語SERIAL OCT AND HISTOPATHOLOGY ANALYSIS FOLLOWING 1ST AND NEW GENERATION DRUG ELUTING STENTS IMPLANTATION IN SWINE CORONARY ARTERY研究発表ペーパー・要旨（国際会議）
- 2012年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E1529 - E1529, 英語DETAILED INVESTIGATION OF VASCULAR RESPONSE BETWEEN PATIENTS WITH OR WITHOUT DIABETES MELLITUS AFTER EVEROLIMUS-ELUTING STENT IMPLANTATION; OPTICAL COHERENCE TOMOGRAPHY STUDY研究発表ペーパー・要旨（国際会議）
- 2012年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E120 - E120, 英語THE IMPACT OF MID-TERM OCT FINDINGS ON LONG-TERM CLINICAL EVENTS AFTER DRUG-ELUTING STENTS IMPLANTATION研究発表ペーパー・要旨（国際会議）
- 2012年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E221 - E221, 英語OPTICAL COHERENCE TOMOGRAPHY ASSESSMENT OF HISTOPATHOLOGY AFTER 1ST AND 2ND GENERATION DRUG-ELUTING STENT IMPLANT IN PIG CORONARY MODEL研究発表ペーパー・要旨（国際会議）
- 2012年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E315 - E315, 英語COMPARISONS OF SAFETY PROFILE BETWEEN DURABLE AND BIODEGRADABLE POLYMER BASED DRUG ELUTING STENTS IN PORCINE CORONARY ARTERY MODEL研究発表ペーパー・要旨（国際会議）
- 2012年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E259 - E259, 英語THE IMPACT OF PARAOXONASE 1 ACTIVITY ON THE INCIDENCE OF INTRA STENT THROMBUS AFTER DRUG ELUTING STENT IMPLANTATION IN THE JAPANESE CYP2C19 LOSS OF FUNCTION POLYMORPHISM CARRIERS研究発表ペーパー・要旨（国際会議）
- 2012年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E89 - E89, 英語NEOINTIMAL COVERAGE OF JAILED STRUT FOLLOWING SINGLE STENTING TO BIFURCATION: OPTICAL COHERENCE TOMOGRAPHY ASSESSMENT FOR 3 TYPES OF DRUG-ELUTING STENTS研究発表ペーパー・要旨（国際会議）
- (公社)日本小児科学会, 2011年12月01日, 日本小児科学会雑誌, 115(12) (12), 1945 - 1945, 日本語トルバプタンが心不全の改善に有効であったミオパチーに伴う拡張型心筋症の1例
- 2011年11月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58(20) (20), B180 - B180, 英語Uniform Vessel Healing after Everolimus-eluting Stent implantation: Detailed Comparison with Paclitaxel-eluting Stent by Optical Coherence Tomography研究発表ペーパー・要旨（国際会議）
- 2011年11月, CIRCULATION, 124(21) (21), 英語Comparison of Angioscope and Optical Coherence Tomography findings for the Assessment of Intra-stent Thrombus and Neointima at 8 months After Sirolimus-Eluting Stent Implantation研究発表ペーパー・要旨（国際会議）
- 2011年11月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58(20) (20), B72 - B72, 英語Elevated Pre-procedural High-sensitive CRP Levels are Associated with Uneven Vessel Healing after Paclitaxel-eluting Stents Implantation in Patients with Stable Angina研究発表ペーパー・要旨（国際会議）
- 2011年11月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58(20) (20), B181 - B181, 英語In-vivo Assessment of Neoatherosclerosis after Sirolimus-eluting Stent implantation: Comparisons of Serial Optical Coherence Tomography Findings between Early and Late Follow-up研究発表ペーパー・要旨（国際会議）
- 2011年11月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58(20) (20), B169 - B169, 英語Impact of Stent Platform of Paclitaxel-eluting Stents: Detailed Assessment of Neointimal Distribution by Optical Coherence Tomography研究発表ペーパー・要旨（国際会議）
- 2011年11月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58(20) (20), B49 - B49, 英語The impact of paraoxonase-1 activity on the incidence of intra-stent thrombus after drug-eluting stent implantation in the Japanese CYP2C19*2 carriers receiving clopidogrel研究発表ペーパー・要旨（国際会議）
- 日本臨床社, 2011年09月, Nihon Rinsho., 69, 350 - 354, 日本語Qualitative and quantitative assessment of DES restenosis by IVUS and OCT.[査読有り]記事・総説・解説・論説等（学術雑誌）
- 日本臨床社, 2011年09月, Nihon Rinsho., 69, 95 - 102, 日本語Current evidence about lipid-lowering therapy and coronary plaque.[査読有り]記事・総説・解説・論説等（学術雑誌）
- 2011年08月, EUROPEAN HEART JOURNAL, 32, 853 - 854, 英語Natural consequence of stent malapposition tissue prolapse, thrombus and stent edge dissection assessed by optical coherence tomography研究発表ペーパー・要旨（国際会議）
- 2011年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1758 - E1758, 英語VESSEL RESPONSE TO THE NOVEL POLYMER-FREE BIOFREEDOM STENT VERSUS CONVENTIONAL DURABLE POLYMER COATING STENT: SHORT- AND MID-TERM INTRAVASCULAR ULTRASOUND RESULTS FROM THE BIOFREEDOM FIRST-IN-MAN TRIAL研究発表ペーパー・要旨（国際会議）
- 2011年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1860 - E1860, 英語A NOVEL RADIOFREQUENCY SIGNAL ANALYSIS FOR CORONARY PLAQUE CHARACTERIZATION AT CULPRIT LESION USING IMAPTM: HOW CAN WE USE THE NEW PARAMETER: CONFIDENCE LEVEL?研究発表ペーパー・要旨（国際会議）
- 2011年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1744 - E1744, 英語NATURAL CONSEQUENCE OF STENT MALAPOSITION ASSESSED BY OPTICAL COHERENCE TOMOGRAPHY研究発表ペーパー・要旨（国際会議）
- 2011年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1299 - E1299, 英語IMPACT OF CYTOCHROME P450 2C19*2 POLYMORPHISM ON THE TARGET LESION OUTCOME AFTER DRUG-ELUTING STENT IMPLANTATION IN JAPANESE PATIENTS RECEIVING CLOPIDOGREL.研究発表ペーパー・要旨（国際会議）
- 2011年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1210 - E1210, 英語INFLUENCE OF PROTON PUMP INHIBITORS (PPIS) ON THE FORMATION OF INTRA-STENT THROMBUS IN JAPANESE PATIENTS RECEIVING CLOPIDOGREL WITH OR WITHOUT CYTOCHROME P450 2C19*2 POLYMORPHISM研究発表ペーパー・要旨（国際会議）
- 2011年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1723 - E1723, 英語POTENTIAL BENEFIT OF FINAL KISSING INFLATION AFTER SINGLE STENTING TO BIFURCATION LESIONS: DIFFERENCE OF OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN SIROLIMUS AND PACLITAXEL-ELUTING STENTS研究発表ペーパー・要旨（国際会議）
- 2011年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1756 - E1756, 英語NONPOLYMER-BASED BIOLIMUS-ELUTING STENT ACCELERATES OVERALL NEOINTIMAL COVERAGE: SHORT- AND MID-TERM INTRAVASCULAR ULTRASOUND RESULTS FROM STEALTH AND BIOFREEDOM TRIALS研究発表ペーパー・要旨（国際会議）
- 2011年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1731 - E1731, 英語ASSESSMENT OF YELLOW NEOINTIMA AND MURAL THROMBI AFTER 1ST GENERATION SIROLIMUS-ELUTING STENTS USING ANGIOSCOPE AND OPTICAL COHERENCE TOMOGRAPHY研究発表ペーパー・要旨（国際会議）
- メディカ出版, 2011年03月, サーキュレーション・アップ・トゥ・デート, 6, 287 - 295, 日本語OCT (決定版 病棟必携! カラーで診る PCIマニュアル--テクニックとコツの入門書) -- (PCIにおけるイメージング)
- 2010年09月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(13) (13), B56 - B56, 英語Comparison of Vessel Response to Sirolimus-Eluting NEVOTM Stents with Bioabsorbable Polymer Versus Sirolimus-Eluting CypherTM Steeds with Durable Polymer研究発表ペーパー・要旨（国際会議）
- 2010年09月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(13) (13), B54 - B54, 英語Comparison of Polymer -Free BioFreedo Struts with Polymer-BasedTABUS"' Liberte Stems: The 4-Nlonth lotravascular Ultrasound Results from the Bioireedoin First -In -Man Trial研究発表ペーパー・要旨（国際会議）
- 2009年11月, CIRCULATION, 120(18) (18), S915 - S915, 英語Comparison of Sirolimus-Eluting NEVO (TM) Stents With Paclitaxel-eluting CoStar (TM) Stents and Paclitaxel-eluting Taxus Liberte (TM) Stents: Insights From Intravascular Ultrasound Analysis of the Res-elution I and Costar II Trials研究発表ペーパー・要旨（国際会議）
- 2009年11月, CIRCULATION, 120(18) (18), S1000 - S1000, 英語Evaluation of the Peri-strut Low Intensity Area Following Sirolimus- and Paclitaxel-Eluting Stents Implantation: Insights From an Optical Coherence Tomography Study in Humans研究発表ペーパー・要旨（国際会議）
- 2009年09月, AMERICAN JOURNAL OF CARDIOLOGY, 104(6A) (6A), 18D - 18D, 英語Impact of Lumen Narrowing Within Everolimus-Eluting Stents on Downstream Vessel Segments研究発表ペーパー・要旨（国際会議）
- 2009年09月, AMERICAN JOURNAL OF CARDIOLOGY, 104(6A) (6A), 158D - 158D, 英語Single Center, First-In-Man Study of the Elixir Novolimus Elating Coronary Stent System with Durable Polymer 24-Month Clinical Safety and Efficacy Results研究発表ペーパー・要旨（国際会議）
- 2009年09月, AMERICAN JOURNAL OF CARDIOLOGY, 104(6A) (6A), 133D - 133D, 英語Comparison of Sirolimus-Eluting NEVOTM Stents with Paclitaxel-eluting Taxus LieberteTM stents in De Novo Native Coronary Artery Lesions : Intravascular Ultrasound Results From the Reselution I Trial研究発表ペーパー・要旨（国際会議）
- 2009年08月, JACC-CARDIOVASCULAR INTERVENTIONS, 2(8) (8), 807 - 808, 英語速報，短報，研究ノート等（学術雑誌）
- 2008年10月, AMERICAN JOURNAL OF CARDIOLOGY, 102(8A) (8A), 170I - 170I, 英語Vascular Response to Overlapping Everolimus-eluting stents: Comparison with Paclitaxel-eluting Stents研究発表ペーパー・要旨（国際会議）
- 2008年10月, CIRCULATION, 118(18) (18), S1042 - S1042, 英語Efficacy Of The Everolimus-eluting Stent in Diabetic Patients: Comparison With The Paclitaxel-eluting Stent研究発表ペーパー・要旨（国際会議）
- 2008年10月, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 45, S29 - S29, 英語研究発表ペーパー・要旨（国際会議）
- 2008年10月, CIRCULATION, 118(18) (18), S1045 - S1045, 英語Arterial Responses at Proximal and Distal Edges of Everolimus-Eluting Stents: Insights from the Spirit III Randomized Controlled Trial研究発表ペーパー・要旨（国際会議）
- 2008年10月, CIRCULATION, 118(18) (18), S896 - S896, 英語Local Determinants and Clinical Significance of Thrombus Formation Following Sirolimus-Eluting Stent Implantation: Insights from Optical Coherence Tomography Analysis研究発表ペーパー・要旨（国際会議）
- 2008年10月, REVISTA ESPANOLA DE CARDIOLOGIA, 61(10) (10), 1001 - 1006, スペイン語Evaluation of vessel response to percutaneous coronary intervention[査読有り]その他
- 日本心臓病学会, 2008年05月15日, 日本心臓病学会誌 =Journal of cardiology. Japanese edition, 1(3) (3), 169 - 173, 日本語好酸球増多症候群に合併した大動脈弁閉鎖不全症の1例
- 2007年09月, EUROPEAN HEART JOURNAL, 28, 673 - 673, 英語Evaluation of delayed tissue coverage on sirolimus-eluting stents from six-month to twelve-month - optical coherence tomography study研究発表ペーパー・要旨（国際会議）
- 2007年09月, EUROPEAN HEART JOURNAL, 28, 62 - 62, 英語Coronary plaque regression is closely related to the decrease of necrotic-core with increase of plasma adiponectin level: 6-month binary studies with virtual histology intravascular ultrasound研究発表ペーパー・要旨（国際会議）
- 2007年09月, EUROPEAN HEART JOURNAL, 28, 759 - 760, 英語Effect of pioglitazone on coronary plaque volume and components in patients with type 2 diabetes: intravascular ultrasound virtual histology study研究発表ペーパー・要旨（国際会議）
- 2007年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 49(9) (9), 382A - 382A, 英語Lower plasma adiponectin levels and higher oxidative stress are associated with in vivo thin-cap fibroatheroma in patients wth sable agina pctoris研究発表ペーパー・要旨（国際会議）
- 社団法人日本循環器学会, 2007年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 71, 91 - 92, 英語1 Catheter-based Transcoronary Myocardial Hypothermia Attenuates Reperfusion Injury in Pigs with Acute Myocardial Infarction(Discovery of Adjunctive Therapies for Acute Myocardial Infarction-From Bench to Bedside-, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 社団法人日本循環器学会, 2007年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 71, 348 - 349, 英語PE-095 Low Adiponectin Level is Associated with ACS Caused by Plaque Rupture Containing Lipid Necrotic Core(Acute coronary syndrome, basic/clinical-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 2006年10月10日, Japanese journal of interventional cardiology, 21(5) (5), 435 - 441, 日本語慢性期の確認造影時に右冠動脈入口部ステント損傷, 抜去を生じ急性冠閉塞となった1例
- 2006年10月, CIRCULATION, 114(18) (18), 782 - 783, 英語Pioglitazone increases plasma adiponectin concentration and decreases coronary plaque necrotic core: Intravascular ultrasound virtual histology study研究発表ペーパー・要旨（国際会議）
- 2006年10月, AMERICAN JOURNAL OF CARDIOLOGY, 98(8A) (8A), 221M - 221M, 英語Cooperative study with intravascular ultrasound virtual histology and optical copherence tomography for detecting thin cap fibroatheroma in patients with stable coronary artery disease研究発表ペーパー・要旨（国際会議）
- 2006年10月, AMERICAN JOURNAL OF CARDIOLOGY, 98(8A) (8A), 94M - 94M, 英語Factors for neointimal proliferation in sirolimus-eluting stent at 6 month after deployment, optical coherence tomography study研究発表ペーパー・要旨（国際会議）
- 2006年10月, CIRCULATION, 114(18) (18), 645 - 645, 英語Evaluation of long-term changes of neointimal coverage on sirolimus-eluting stents by optical coherence tomography研究発表ペーパー・要旨（国際会議）
- 2006年10月, AMERICAN JOURNAL OF CARDIOLOGY, 98(8A) (8A), 94M - 94M, 英語Change of neointimal coverage on Sirolimus-eluting stents from six month to twelve month - Optical coherence tomography study研究発表ペーパー・要旨（国際会議）
- 2006年10月, CIRCULATION, 114(18) (18), 620 - 620, 英語Human atrial natriuretic peptide improves myocardial efficiency in patients with heart failure due to idiopathic dilated cardiomyopathy研究発表ペーパー・要旨（国際会議）
- 2006年08月, EUROPEAN HEART JOURNAL, 27, 231 - 231, 英語Difference between acute coronary syndrome and stable angina: Relationship between plasma adiponectin, high sensitive C-reactive protein and coronary plaque components研究発表ペーパー・要旨（国際会議）
- 2006年08月, EUROPEAN HEART JOURNAL, 27, 365 - 365, 英語Effect of Angiotensin Receptor Blockade on coronary necrotic core plaque: binary observations with intravascular ultrasound virtual histology研究発表ペーパー・要旨（国際会議）
- 社団法人日本循環器学会, 2006年04月20日, Circulation journal : official journal of the Japanese Circulation Society, 70, 1108 - 1108, 日本語23)Cypher crushed stentを慢性期にoptical coherence tomography (OCT)にて観察した一例(第100回日本循環器学会近畿地方会)
- 社団法人日本循環器学会, 2006年04月20日, Circulation journal : official journal of the Japanese Circulation Society, 70, 1108 - 1108, 日本語24)ステント内再狭窄病変に対しエキシマレーザー冠動脈形成術を行い,切除結果をOCTで観察した2症例(第100回日本循環器学会近畿地方会)
- 社団法人日本循環器学会, 2006年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 70, 266 - 266, 英語OJ-129 Elevation of Plasma C-Reactive Protein is Associated with Histological Plaque Composition in Patients with Acute Coronary Syndromes(Acute coronary syndrome, basic/clinical-2 (IHD) OJ22,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 社団法人日本循環器学会, 2006年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 70, 511 - 511, 英語PJ-090 Evaluation of Sirolimus-eluting Stent Mal-apposition by Optical Coherence Tomography(Intravascular endoscopy/Intravascular ultrasound-6 (I) PJ15,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 社団法人日本循環器学会, 2006年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 70, 453 - 453, 英語PE-481 Prognostic Importance of Increased Left Ventricular Myocardial Stiffness in Patients with Recurrent Diastolic Heart Failure(Heart failure, clinical-9 (M) PE81,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 社団法人日本循環器学会, 2006年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 70, 301 - 301, 英語OJ-268 Optical Coherence Tomography Visualize Thin Neointima on Sirolimus-eluting Stent More Precisely than Intravascular Ultrasound at Six Month Follow-up(Intravascular endoscopy/Intravascular ultrasound-2 (I) OJ45,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 社団法人日本循環器学会, 2006年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 70, 300 - 300, 英語OJ-265 Plasma Adiponectin Levels are Associated with Plaque Component in Patients with Ischemic Heart Disease(Intravascular endoscopy/Intravascular ultrasound-2 (I) OJ45,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 2005年10月, AMERICAN JOURNAL OF CARDIOLOGY, 96(7A) (7A), 186H - 186H, 英語Evaluation of neointimal hyperplasia by optical coherence tomography at six month after sirolimus eluting stent deployment研究発表ペーパー・要旨（国際会議）
- 2005年10月, AMERICAN JOURNAL OF CARDIOLOGY, 96(7A) (7A), 176H - 176H, 英語Effects of overlapping sirolimus-eluting stent on neointimal proliferation in long coronary lesions: Optical coherence tomography study研究発表ペーパー・要旨（国際会議）
- 2005年10月, CIRCULATION, 112(17) (17), U514 - U514, 英語Therapeutic doses of human atrial natriuretic peptide have different effects on myocardial contractility in patients with systolic heart failure and left ventricular hypertrophy研究発表ペーパー・要旨（国際会議）
- 社団法人日本循環器学会, 2005年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 69, 183 - 183, 英語Effectiveness of Catheter-based Trans-coronary Myocardial Hypothermia on Attenuating Myocardial Necrosis in Pigs with Acute Myocardial Infarction(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- 社団法人日本循環器学会, 2005年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 69, 235 - 235, 英語Multivariate Analysis of Hemodynamic Parameters for Increase in Plasma BNP in Systolic and Diastolic Heart Failure ; Importance of Myocardial Stiffness(Heart Failure, Clinical 13 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- 社団法人日本循環器学会, 2003年04月20日, Circulation journal : official journal of the Japanese Circulation Society, 67, 817 - 817, 日本語26)New distal protection device(PercuSurge^
)を用いた急性冠症候群における一検討 - 社団法人日本循環器学会, 2003年04月20日, Circulation journal : official journal of the Japanese Circulation Society, 67, 828 - 828, 日本語135)心房細動に対する塩酸ベプリジル投与の検討
- 共編者(共編著者), メディカ出版, 2011年03月, 日本語PCIマニュアル / PCIにおけるイメージング：OCT教科書・概説・概論
- 共著, Oxford University Press, 2010年, 英語Oxford text book of interventional cardiology / The role of intravascular ultrasound in percutaneous coronary intervention教科書・概説・概論
- 第83回日本循環器学会学術集会, 2019年03月, 日本語, 日本循環器学会, 横浜, 国内会議The morphological characteristics and insufficient lipid control might promote intimal thickening of saphenous vein graft after coronary artery bypass grafting口頭発表（一般）
- 第83回日本循環器学会学術集会, 2019年03月, 日本語, 日本循環器学会, 横浜, 国内会議The impact of glucose fluctuation on cardiovascular outcome in patients with stable coronary artery diseaseシンポジウム・ワークショップパネル（公募）
- 第83回日本循環器学会学術集会, 2019年03月, 英語, 日本循環器学会, 横浜, 国内会議The concomitant use of statin and eicosapentaenoic acid prevented atherosclerotic progression in both in-stent neoatherosclerosis and native coronary plaques.口頭発表（一般）
- 第83回日本循環器学会学術集会, 2019年03月, 日本語, 日本循環器学会, 横浜, 国内会議Post-stent irregular protrusion is associated with future development of neoatherosclerosis: Insights from the MECHANISM-AMI study口頭発表（一般）
- 第83回日本循環器学会学術集会, 2019年03月, 英語, 日本循環器学会, 横浜, 国内会議Plaque progression from normal vessel wall to fibroatheroma: lessons from over 5-year follow-up optical coherence tomography study口頭発表（一般）
- 第83回日本循環器学会学術集会, 2019年03月, 日本語, 日本循環器学会, 横浜, 国内会議Novel Approach for In-vivo Detection of Vulnerable Plaques: Computational Fluid Dynamics in Optical Coherence Tomography and Computed Tomography Merged Modelシンポジウム・ワークショップパネル（公募）
- 第83回日本循環器学会学術集会, 2019年03月, 英語, 日本循環器学会, 横浜, 国内会議Evaluation of Microvasculopathy using Dual-Energy CT in Chronic Thromboembolic Pulmonary Hypertensionポスター発表
- 第83回日本循環器学会学術集会, 2019年03月, 日本語, 日本循環器学会, 横浜, 国内会議Different vascular reaction to everolimus-eluting stents implantation between stable angina and ST elevation myocardial infarction: Insights from MECHANISM studies口頭発表（一般）
- 第83回 日本循環器学会学術集会, 2019年03月, 英語, 日本循環器学会, 横浜, Background: Cholesterol efflux capacity (CEC) measurement is not instantly applicable in clinical settings, because the procedures require cultured cells and are time consuming. Recently, we established a simple, high-throughout, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as “cholesterol uptake capacity (, 国内会議Comparison of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, and Cholesterol Efflux Capacity in Association with Coronary Plaque Propertiesポスター発表
- 第83回日本循環器学会学術集会, 2019年03月, 英語, 日本循環器学会, 横浜, 国内会議Clinical characteristics and morphological culprit plaque features in patients with acute coronary syndrome口頭発表（一般）
- 第83回日本循環器学会学術集会, 2019年03月, 英語, 日本循環器学会, 横浜, 国内会議A possible link between asymmetric expansion of SAPIEN 3 transcatheter heart valve and hypo-attenuated leaflet thickeningポスター発表
- 第35回 国際心臓研究学会日本部会, 2018年12月, 英語, 国際心臓研究学会日本部会, 東京, Background: Cholesterol efflux capacity (CEC) measurement is not instantly applicable in clinical settings, because the methods require cultured cells, and the procedures are time consuming. Recently, we established a simple, high-throughout, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as “cholesterol upta, 国内会議Comparison of Clinical Utility Between Cholesterol Uptake Capacity, a Novel Indicator of HDL Functionality, and Cholesterol Efflux Capacityポスター発表
- American Heart Association Scientific Sessions 2018., 2018年11月, 英語, American Heart Association, シカゴ, Background: Cholesterol efflux capacity (CEC) measurement is not instantly applicable in clinical settings, because the methods require cultured cells, and the procedures are time consuming. Recently, we established a simple, high-throughout, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as “cholesterol upta, 国際会議Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, Versus Cholesterol Efflux Capacity in Association with Coronary Plaque Lipid Burdenポスター発表
- 日本超音波医学会 第45 回関西地方会学術集会, 2018年10月, 日本語, 神戸, 国内会議経カテーテル的心房中隔閉鎖術が奏功した超高齢者重症心不全の一例口頭発表（一般）
- 第66回 日本心臓病学会, 2018年09月, 英語, 日本心臓病学会, 大阪, 国内会議The Impact of P2Y12 Reaction Unit on Intra-stent Tissues and Peri-procedural Myocardial Injury in Stable Angina Pectorisポスター発表
- Transcatheter Cardiovascular Therapeutics (TCT 2018), 2018年09月, 英語, 心血管研究財団, サンディエゴ, 国際会議The concomitant use of statin and eicosapentaenoic acid prevented atherosclerotic progression in both in-stent neoatherosclerosis and native coronary plaques.ポスター発表
- Transcatheter Cardiovascular Therapeutics (TCT2018), 2018年09月, 英語, 心血管研究財団, サンディエゴ, 国際会議Prediction of debulking effect of rotational atherectomy by optical frequency domain imagingポスター発表
- Transcatheter Cardiovascular Therapeutics (TCT 2018), 2018年09月, 英語, 心血管研究財団, サンディエゴ, 国際会議Impact of dual antiplatelet therapy with low-dose prasugrel on mid-term vascular response after everolimus-eluting stent implantation in elective percutaneous coronary interventionポスター発表
- 第27回日本心血管インターベンション治療学会, 2018年08月, 日本語, 日本心血管インターベンション治療学会, 神戸, 国内会議慢性血栓塞栓性肺高血圧に対する肺動脈内膜血栓摘除術及びバルーン肺動脈形成術の特性を活かしたハイブリッド療法シンポジウム・ワークショップパネル（公募）
- 第27回日本心血管インターベンション治療学会学術集会, 2018年08月, 日本語, 日本心血管インターベンション治療学会, 神戸, 国内会議慢性血栓塞栓性肺高血圧に対する肺動脈内膜血栓摘除術及びバルーン肺動脈形成術の特性を活かしたハイブリッド療法シンポジウム・ワークショップパネル（公募）
- 第27回日本心血管インターベンション治療学会, 2018年08月, 日本語, 日本心血管インターベンション治療学会, 神戸, 国内会議TAVR後、人口弁への血栓形成を認めた血小板低下患者の一例口頭発表（一般）
- EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2018(ESC 2018), 2018年08月, 英語, European Society of Cardiology, ミュンヘン, 国際会議Lung perfusion recovery evaluated by dual-energy CT correlated with the improvement of exercise capacity in chronic thromboembolic pulmonary hypertensionポスター発表
- ESC Congress 2018, 2018年08月, 英語, European Sciety of Cardiology, ミュンヘン, 国際会議Lung perfusion recovery evaluated by dual-energy CT correlated with the improvement of exercise capacity in chronic thromboembolic pulmonary hypertensionポスター発表
- EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2018(ESC 2018), 2018年08月, 英語, European Society of Cardiology, ミュンヘン, 国際会議Impact of irregular protrusion immediately after stent implantation on mid-term vascular healing in ST elevation myocardial infarction: Results from MECHANISM AMI optical coherence tomography studyポスター発表
- 第27回日本心血管インターベンション治療学会, 2018年08月, 日本語, 日本心血管インターベンション治療学会, 神戸, 国内会議FFRCTの可能性公開講演，セミナー，チュートリアル，講習，講義等
- 第66回 日本心臓病学会学術集会, 2018年08月, 英語, 日本心臓病学会, 大阪, Background: Excessive intake of trans-fatty acids (TFAs) has been known to increase cardiovascular risk in Western countries. However, few studies have been reported on the effect of TFAs as a risk of coronary artery disease (CAD) in Japan. Recently, we demonstrated that serum TFAs concentration was elevated in young patients with CAD in Japan. In this study, we investigated wh, 国内会議Elevation of Serum Trans-fatty Acids Level as a Possible Risk for Target Lesion Revascularization After Coronary Intervention口頭発表（一般）
- EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2018(ESC 2018), 2018年08月, 英語, European Society of Cardiology, ミュンヘン, 国際会議Difference of vascular reaction to 2nd generation DES between stable angina and ST elevation myocardial infarction : Results from MECHANISM optical coherence tomography studyポスター発表
- EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2018(ESC 2018), 2018年08月, 英語, European Society of Cardiology, ミュンヘン, 国際会議Comparison between pulmonary endarterectomy and balloon pulmonary angioplasty focusing on RC time constant and pulmonary artery compliance in chronic thromboembolic pulmonary hypertension.ポスター発表
- ESC Congress 2018, 2018年08月, 英語, European Society of Cardiology, ミュンヘン, 国際会議Comparison between pulmonary endarterectomy and balloon pulmonary angioplasty focusing on RC time constant and pulmonary artery compliance in chronic thromboembolic pulmonary hypertension.ポスター発表
- 第3回 日本肺高血圧・肺循環学会学術集会, 2018年06月, 日本語, 日本肺高血圧・肺循環学会, 大阪, 国内会議CTEPHに対する治療効果及びRC timeの臨床的意義について口頭発表（一般）
- 第3回日本肺高血圧・肺循環学会学術集会, 2018年06月, 日本語, 日本肺高血圧学会日本肺循環学会共催, 大阪, 国内会議CTEPH に対する治療効果の比較及びRC time の臨床的意義について口頭発表（一般）
- EuroPCR 2018, 2018年05月, 英語, European Association of Percutaneous Cardiovascular Interventions (EAPCI), パリ, 国際会議Exploring MECHANISM of early and late vascular responses of sirolimus-eluting stent with bioresorbable polymer for treatment of STEMI and SAP patients -Primary endpoint results of MECHANISM-ULTIMASTER trial口頭発表（一般）
- 第55回 日本臨床分子医学会学術集会, 2018年04月, 日本語, 日本臨床分子医学会, 京都, 【背景】 高比重リポ蛋白（HDL）の、コレステロールをマクロファージより引き抜く能力cholesterol efflux capacityがHDL中のコレステロール（HDL-C）値より心血管疾患のリスク評価に優れるが、その従来の測定法は放射性同位体や培養細胞を要すなど臨床応用は非現実的であった。当施設で、HDLのコレステロール取り込み能をより簡便に評価できる新規HDL機能評価法“cholesterol uptake capacity (CUC)”を構築し、臨床応用を目指している。この引き抜き能と動脈硬化病変のプラーク性状の関係性に関しこれまでに十分評価はされていない。【方法】 冠動脈病変に対し冠動脈造影検査および光干渉断層映像法（OCT）を施行した135例でCUCを測定しOCT画像解析によるプラーク性状との比較検討を行った。OCT画像上、脂質プラーク, 国内会議HDL機能の新規評価法“Cholesteroluptakecapacity”とOCT解析によ る冠動脈プラーク病変性状の比較検討ポスター発表
- 第82回 日本循環器学会学術集会, 2018年03月, 英語, 日本循環器学会, 大阪, 国内会議Treatment goal of BPA would be extensive perfusion recovery beyond hemodynamic normalizationポスター発表
- 第82回 日本循環器学会学術集会, 2018年03月, 英語, 日本循環器学会, 大阪, 国内会議Sequential Hybrid Therapy with Pulmonary Endarterectomy and Additional Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension（ポスター発表）ポスター発表
- 第82回日本循環器学会学術集会, 2018年03月, 英語, 日本循環器学会, 大阪, Background: Recently, we established a simple, high-throughput, cell-free assay system to evaluate the capacity of high-density lipoprotein (HDL) to accept additional cholesterol, named cholesterol uptake capacity (CUC). In this study, we sought to clarify the cross-sectional relationship between CUC and coronary plaque morphology.Methods: We enrolled 135 patients to measure CU, 国内会議Relationships between Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, and Morphologic Features of Coronary Plaqueポスター発表
- 第82回日本循環器学会学術集会, 2018年03月, 英語, 日本循環器学会, 大阪, 国内会議Relationship among Aortic Elongation, Tortuosity, and Configurations of the Aortic Root in Candidates for Transcatheter Aortic Valve Replacementポスター発表
- 第67回米国心臓病学会議, 2018年03月, 英語, American College Of Cardiology, オーランド, 米国, 国際会議Impaired HDL cholesterol uptake capacity which measure HDL functionality might promote neoatherosclerosis formation after stent implantationポスター発表
- 第82回日本循環器学会学術集会, 2018年03月, 英語, 日本循環器学会, 大阪, 国内会議Impact of Aortic Valve Calcification Burden and Distribution on Postprocedural Cardiac Conduction Disturbances following Transcatheter Aortic Valve Replacementポスター発表
- 6th World Symposium on Pulmonary Hypertension, 2018年02月, 英語, 6th World Symposium on Pulmonary Hypertension working group, ニース, フランス, 国際会議Sequential hybrid therapy with pulmonary endarterectomy and additional balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension.ポスター発表
- 6th World Symposium on Pulmonary Hypertension, 2018年02月, 英語, 6th World Symposium on Pulmonary Hypertension working group, ニース, フランス, 国際会議Pulmonary Blood Volume by Dual-energy CT is a new management index for chronic thromboembolic pulmonary hypertensionポスター発表
- 6th World Symposium on Pulmonary Hypertension, 2018年02月, 英語, 6th World Symposium on Pulmonary Hypertension working group, ニース, フランス, 国際会議Predictors for worsening hemodynamics during follow-up period after balloon pulmonary angioplastyポスター発表
- 第124回日本循環器学会近畿地方会, 2017年11月, 日本語, 日本循環器学会, 大阪, 国内会議慢性血栓塞栓性肺高血圧症に対するバルーン拡張術におけるpressure wireを用いた病変別急性効果の検討口頭発表（一般）
- American Heart Association Scientific Sessions 2017, 2017年11月, 英語, American Heart Association Scientific Sessions 2017, アナハイム, USA, 国際会議Pulmonary blood volume evaluated by dual-energy CT is a new maker for the management of chronic thromboembolic pulmonary hypertensionポスター発表
- American Heart Association Scientific sessions 2017, 2017年11月, 英語, American Heart Association, Anaheim, USA, Background: Recent studies have shown that the capacity of high density lipoprotein (HDL) to stimulate cholesterol efflux from lipid-laden macrophages is a better predictor of cardiovascular disease than overall HDL cholesterol level. However, the conventional procedure for measuring efflux capacity requires radiolabeled cholesterol and cultured cells. Recently, we established, 国際会議Association of Coronary Lipidic Plaque Burden with Impairment of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality: OCT-based Observation Study口頭発表（一般）
- Transcatheter Cardiovascular Therapeutics (TCT 2017), 2017年10月, 英語, 心血管研究財団, デンバー, 米国, 国際会議The combination of rosuvastatin (10mg) and eicosapentaenoic acid (1800mg) improved native coronary plaques > 5.7 years after stent implantation口頭発表（一般）
- Transcatheter Cardiovascular Therapeutics (TCT 2017), 2017年10月, 英語, 心血管研究財団, デンバー, 米国, 国際会議The clinical impact of daily glucose fluctuation on cardiovascular events in patients with stable angina pectoris pretreated with lipid-lowering therapyポスター発表
- Transcatheter Cardiovascular Therapeutics (TCT 2017), 2017年10月, 英語, 心血管研究財団, デンバー, 米国, 国際会議High Wall Shear Stress Was Strongly Associated with Plaque Vulnerability in Computational Fluid Dynamics with Combined Optical Coherence Tomography and Heartflow FFRCT Simulationポスター発表
- Transcatheter Cardiovascular Therapeutics (TCT 2017), 2017年10月, 英語, 心血管研究財団, デンバー, 米国, 国際会議Different tissue morphology of in-stent restenosis in hemodialysis patients compared with non-hemodialysis patients: a prospective multicenter optical coherence tomography registry口頭発表（一般）
- EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2017(ESC 2017), 2017年08月, 英語, European Society of Cardiology, バルセロナ, スペイン, 国際会議The Impact of P2Y12 Reaction Unit during Percutaneous Coronary Intervention on Intra-stent Tissues and Peri-procedural Myocardial Injury in Stable Angina Pectoris; from MECHANISM-elective studyポスター発表
- EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2017(ESC 2017), 2017年08月, 英語, European Society of Cardiology, バルセロナ, スペイン, 国際会議Lesional and clinical impact of drug-coating balloon on in-stent restenosis compared with conventional balloon angioplasty: a prospective multicentre optical coherence tomography registry口頭発表（一般）
- 第26回日本心血管インターベンション治療学会, 2017年07月, 日本語, 日本心血管インターベンション治療学会, 京都, 国内会議IVUSを用いたbail out[招待有り]口頭発表（招待・特別）
- 第26回日本心血管インターベンション治療学会, 2017年07月, 英語, 日本心血管インターベンション治療学会, 京都, 国内会議IVUS-guided vs. OFDI-guided PCI: Clinical trial evidence[招待有り]口頭発表（招待・特別）
- 第26回日本心血管インターベンション治療学会, 2017年07月, 日本語, 日本心血管インターベンション治療学会, 京都, 国内会議Follow-up OCT in BRS[招待有り]口頭発表（招待・特別）
- 第26回日本心血管インターベンション治療学会, 2017年07月, 英語, 日本心血管インターベンション治療学会, 京都, 国内会議Coronary physiology in Japan[招待有り]口頭発表（招待・特別）
- International CTEPH conference 2017, 2017年06月, 英語, International CTEPH association, Leuven, ベルギー, 国際会議Characteristics of pressure gradient in each lesions before and after balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertensionポスター発表
- EuroPCR 2017, 2017年05月, 英語, European Association of Percutaneous Cardiovascular Interventions (EAPCI), パリ, フランス, 国際会議Lumen boundaries extracted from coronary CT angiography on computed FFR (FFRCT): validation with OCT口頭発表（一般）
- 第84回日本循環器学会学術大会, 2017年03月, 英語, 日本循環器学会, 金沢, 国内会議Serum Phosphate Level Predicts Total Aortic Calcification Burden in Patients with Severe Aortic Stenosis口頭発表（基調）
- 第81回 日本循環器学会学術集会, 2017年03月, 英語, 日本循環器学会, 金沢, 国内会議Safety of Complete Revascularization of Balloon Pulmonary Angioplasty on Chronic Thromboembolic Pulmonary Hypertension beyond Normalized Mean Pulmonary Arterial Pressureポスター発表
- 第82回 日本循環器学会学術集会, 2017年03月, 英語, 日本循環器学会, 金沢, Background: High-Density lipoprotein (HDL) function is a better predictor of cardiovascular disease than HDL cholesterol level. Recently, we established a simple, high-throughout, cell-free assay system to evaluate "cholesterol uptake capacity (CUC)" as a novel concept for HDL functionality. We aimed to investigate the association between CUC and coronary plaque burden. Methods, 国内会議Inverse Association Between HDL Cholesterol Uptake Capacity And Coronary Atherosclerotic Burden: OCT-based Observation Study口頭発表（一般）
- 第81回日本循環器学会学術大会, 2017年03月, 英語, 日本循環器学会, 金沢, 国内会議Comparison of Left Ventricular Outflow Tract Area Estimated by Transthoracic Echocardiography and Measured by Computed Tomographyポスター発表
- 第85回 日本循環器学会学術集会, 2017年03月, 英語, 日本循環器学会, 金沢, While there is a controversy regarding the clinical significance of high-density lipoprotein cholesterol (HDL-C), recent studies have highlighted the quality of HDL particle as a novel target for cardiovascular risk stratification. However, it is difficult to validate the impact of dysfunctional HDL without clinically practicable tests for HDL quality. Here, we introduce our ch, 国内会議Clinical and Practical Assessment of Dysfunctional HDL in Cardiovascular Risk Stratification口頭発表（基調）
- 第85回日本循環器学会学術大会, 2017年03月, 英語, 日本循環器学会, 金沢, 国内会議Aortic Valve Calcification Density Predicts the Hemodynamic Severity of Aortic Stenosis Independently of Aortic Valve Areaポスター発表
- Transcatheter Cardiovascular Therapeutics (TCT 2016), 2016年10月, 英語, 心血管研究財団, ワシントンDC, 米国, 国際会議Why does thin-cap fibroatheroma cluster in the proximal segment in left anterior coronary artery, but are evenly distributed throughout the entire right coronary artery? –Results from computational fluid dynamics simulation by CT-FFR-ポスター発表
- Transcatheter Cardiovascular Therapeutics (TCT 2016), 2016年10月, 英語, 心血管研究財団, ワシントンDC, 米国, 国際会議OPINION:OCT Follow-Up Substudy from a RandomizedTrial of OFDI-Guided PCI vs. IVUS-Guided PCI[招待有り]口頭発表（招待・特別）
- Transcatheter Cardiovascular Therapeutics (TCT 2016), 2016年10月, 英語, 心血管研究財団, ワシントンDC, 米国, 国際会議Efficacy and safety of sequential hybrid therapy with pulmonary endarterectomy and additional balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension口頭発表（一般）
- 第121回日本循環器学会近畿地方会, 2016年07月, 日本語, 日本循環器学会近畿支部, 京都, 【目的】経皮的心房中隔欠損閉鎖術（ASO）後の両心室の変化と、左室の心拍出量増加に寄与する因子が何であるかを検討すること。【方法】対象はASOが施行された心房中隔欠損症70例。術前および術後3ヶ月に左室心筋機能の評価として、global longitudinal strainとLV dispersion（左室収縮のばらつき）を、右室収縮能指標としてRV free-wall strainを算出した。【結果】ASO後にRV free-wall strainは有意に低下し、LV dispersionは有意に低下した。多変量解析ではRV free-wall strainの変化率とLV dispersionの変化率が、ASO後の左室心拍出量の増加に寄与する独立した規定因子であった。【結語】LV dispersionならびにRV free-wall strain, 国内会議経皮的心房中隔欠損閉鎖術前後における両心室間の相互作用と心拍出量増加について口頭発表（一般）
- 第25回日本心血管インターベンション治療学会, 2016年07月, 日本語, 日本心血管インターベンション治療学会, 東京, 国内会議プラークの不安定化に対する新規アプローチ-血行力学的評価の重要性-[招待有り]シンポジウム・ワークショップパネル（指名）
- 第25回日本心血管インターベンション治療学会, 2016年07月, 日本語, 日本心血管インターベンション治療学会, 東京, 国内会議PCIに必要なイメージングデバイス OCTその他
- 第80回日本循環器学会学術集会, 2016年03月, 日本語, 日本循環器学会, 仙台, Background: Atrial septal defect (ASD) causes chronic volume overload on right-sided heart, but the potential adverse effects of this long-standing volume overload to left ventricle as well as the response to ASD closure remains unclear. Methods: Fifty-three ASD patients, who underwent transcatheter closure, were studied. Transthoracic echocardiography was performed before and, 国内会議経皮的心房中隔欠損閉鎖術前後における両心室間の相互作用について口頭発表（一般）
- 第18回日本成人先天性心疾患学会学術集会, 2016年01月, 日本語, 日本成人先天性心疾患学会 (JSACHD), 大阪, 国内会議先天性心疾患由来肺高血圧症における術後肺高血圧症の特徴シンポジウム・ワークショップパネル（公募）
- 第18回日本成人先天性心疾患学会 総会, 2016年01月, 日本語, 日本成人先天性心疾患学会, 大阪, 【背景】近年高齢者の心房中隔欠損（ASD）患者における経皮的心房中隔欠損閉鎖術（ASO）は増加傾向にある。その一方でASO前後における両心室間の相互関係や、ASO後の左室心拍出量の増加に寄与する因子については十分に検討されていない。【目的】ASO術後長期における両心室の変化を検討することと、ASO前後で左室の心拍出量増加に寄与する因子が何であるかを検討した。【方法】ASOを施行されたASD患者70名を対象とした。患者の平均年齢は57±16歳で42例（60％）が女性であった。また左室駆出率は72±8%（全て≥55％）を対象とし、術前および術後3ヶ月に心臓超音波検査を施行し、それに加えspeckle-tracking法を用いて、18領域のpeak strain値の平均であるGlobal longitudinal strain (GLS)、各18領域におけ, 国内会議経皮的心房中隔欠損閉鎖術前後における両心室間の相互作用についてポスター発表
- 第18回日本成人先天性心疾患学会 総会, 2016年01月, 日本語, 日本成人先天性心疾患学会, 大阪, Background: Prognostic factors after transcatheter closure for adult patients with atrial septal defect (ASD) have not been fully identified. Methods: Forty-nine patients who underwent transcatheter ASD closure were recruited for this study. Echocardiogra, 国内会議Utility of Isovolumic Contraction Peak Velocity for Evaluation of Adult Patient Status after Transcatheter Closure of Atrial Septal Defect口頭発表（一般）
- 第26回日本心血管画像動態学会, 2016年01月, 日本語, 日本心血管画像動態学会, 東京, 国内会議All bout FFRCT:FFRCTはGame Changerになりうるか[招待有り]シンポジウム・ワークショップパネル（指名）
- EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2015(ESC 2015), 2015年08月, 英語, European Society of Cardiology, ロンドン, 英国, 国際会議The impact of in-stent neoatherosclerosis on long-term clinical outcomes: an observational study from the optical coherence tomography registryポスター発表
- 第24回日本心血管インターベンション治療学会, 2015年07月, 日本語, 日本心血管インターベンション治療学会, 福岡, 国内会議臨床兆候からみたPCIのAppropriateness[招待有り]シンポジウム・ワークショップパネル（指名）
- 第24回日本心血管インターベンション治療学会, 2015年07月, 日本語, 日本心血管インターベンション治療学会, 福岡, 国内会議新しい半導体システム D-SPECTの有用性シンポジウム・ワークショップパネル（公募）
- 第24回日本心血管インターベンション治療学会, 2015年07月, 日本語, 日本心血管インターベンション治療学会, 福岡, 国内会議The Impact of Plaque Characteristics on Visual-functional Mismatch assessed by OCT, IVUS, and FFR[招待有り]シンポジウム・ワークショップパネル（指名）
- 第79回日本循環器学会総会, 2015年04月, 英語, 日本循環器学会, 大阪, 国内会議The Assessment of Exercise Tolerance and Oxygenation after Balloon Pulmonary Angioplasty for Inoperable Chronic Thromboembolic Pulmonary Hypertension Patientsポスター発表
- 第79回日本循環器学会学術集会, 2015年04月, 日本語, 日本循環器学会, 大阪, 国内会議Four top reasons to use OCT during PCIシンポジウム・ワークショップパネル（公募）
- ACC.15 64th Annual Scientific & Expo, 2015年03月, 英語, American College of Cardiology, San Diego, US, 国際会議High Perfusion Pressure as a Predictor of Reperfusion Pulmonary Injury after Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertensionポスター発表
- 第11回韓国心血管インターベンション年次学術総会, 2015年01月, 英語, 韓国心血管インターベンション協会, 済州島, 韓国, 国際会議The predictors and clinical impact of neoatherosclerosis after drug-eluting stent[招待有り]シンポジウム・ワークショップパネル（指名）
- 第25回日本心血管画像動態学会, 2015年01月, 日本語, 日本心血管画像動態学会, 東京, 国内会議OCT/OFDIを用いた新時代の冠動脈インターベンション[招待有り]シンポジウム・ワークショップパネル（指名）
- ストラクチャージャパン ライブデモンストレーション2014, 2014年11月, 日本語, ストラクチャージャパン, 東京, 国内会議慢性血栓塞栓性肺高血圧症に対する血栓内膜摘除術とバルーン肺動脈形成術のハイブリッド治療にて良好な結果を得られた一例口頭発表（一般）
- 第62回日本心臓病学会学術集会, 2014年09月, 英語, 日本心臓病学会, 仙台, 国内会議高齢者に対する経皮的心房中隔欠損閉鎖術の治療効果についての検討口頭発表（一般）
- 第62回日本心臓病学会学術集会, 2014年09月, 日本語, 日本心臓病学会, 仙台, 国内会議ステントプラットフォームがステント留置後血管内ずり応力に与える影響[招待有り]シンポジウム・ワークショップパネル（指名）
- 2014年欧州心臓学会議, 2014年08月, 英語, ヨーロッパ心臓協会, バルセロナ, スペイン, 国際会議The Impact of Final Kissing Balloon Inflation on Vessel Healing Following Drug-eluting Stent Implantation: Insight from the Optical Coherence Tomography Sub-study of J-REVERSE Trialポスター発表
- 2014年欧州心臓学会議, 2014年08月, 英語, ヨーロッパ心臓協会, バルセロナ, スペイン, 国際会議Reduced benefit of final kissing balloon inflation after single stenting to bifurcation lesions in patients with diabetes : Insight from the optical coherence tomography sub-study of J-REVERSE trialポスター発表
- 2014年欧州心臓学会議, 2014年08月, 英語, ヨーロッパ心臓協会, バルセロナ, スペイン, 国際会議Lower On-treatment Platelet Reactivity at the Time of Stent Placement Contributes to the Resolution of Post-procedural Intra-stent Thrombus: Serial OCT Observation in PRASFIT-Electiveポスター発表
- 2014年欧州心臓学会議, 2014年08月, 英語, ヨーロッパ心臓協会, バルセロナ, スペイン, 国際会議Difference of Vessel Healings between Sirolimus- and Everolimus-eluting Stent Implantation in Bifurcation Lesions: from J-REVERSE OCT Sub-studyポスター発表
- 第23回日本心血管インターベンション治療学会, 2014年07月, 英語, 日本心血管インターベンション治療学会, 名古屋, 国内会議留置直後に形成されたステント内血栓の消退に及ぼす、血小板凝集抑制の効果: PRASFIT-Elective OCTサブ解析シンポジウム・ワークショップパネル（公募）
- 第23回日本心血管インターベンション治療学会学術集会, 2014年07月, 日本語, 日本心血管インターベンション治療学会, 名古屋, 国内会議慢性血栓塞栓性肺高血圧症に対するバルーン血管拡張術において、血管造影上のバンド形態は圧較差の改善が小さい口頭発表（一般）
- 第23回日本心血管インターベンション治療学会, 2014年07月, 日本語, 日本心血管インターベンション治療学会, 名古屋, 国内会議分岐部病変に対するPCIをOCTで評価するシンポジウム・ワークショップパネル（公募）
- 第23回日本心血管インターベンション治療学会, 2014年07月, 日本語, 日本心血管インターベンション治療学会, 名古屋, 国内会議次世代型 MOMO Bare-metal stentにかける期待-初期臨床成績とWall shear stress simulationの結果から口頭発表（一般）
- 第23回日本心血管インターベンション治療学会, 2014年07月, 日本語, 日本心血管インターベンション治療学会, 名古屋, 国内会議ステント内新規動脈硬化病変が遅発性血栓症に与える影響口頭発表（一般）
- 第23回日本心血管インターベンション治療学会, 2014年07月, 英語, 日本心血管インターベンション治療学会, 名古屋, 国内会議The Mid-term Outcome of Transcatheter Closure of Atrial Septal Defect in the elderly口頭発表（一般）
- 第23回日本心血管インターベンション治療学会, 2014年07月, 英語, 日本心血管インターベンション治療学会, 名古屋, 国内会議The Impact of Final Kissing Balloon Inflation on Vessel Healing Following Drug-eluting Stent Implantation: Insight from the Optical Coherence Tomography Sub-study of J-REVERSE Trial口頭発表（一般）
- 第23回日本心血管インターベンション治療学会, 2014年07月, 英語, 日本心血管インターベンション治療学会, 名古屋, 国内会議ST上昇型心筋梗塞患者における第2世代薬剤溶出性ステントとベアメタルステント留置2週間後の血管反応の検討シンポジウム・ワークショップパネル（公募）
- 第23回日本心血管インターベンション治療学会, 2014年07月, 日本語, 日本心血管インターベンション治療学会, 名古屋, 国内会議OCTをいかにPCIと患者予後改善に生かすかシンポジウム・ワークショップパネル（公募）
- 第23回日本心血管インターベンション治療学会, 2014年07月, 英語, 日本心血管インターベンション治療学会, 名古屋, 国内会議Impact of Underneath Plaque Characteristics on the Fate of Acute Incomplete Strut Apposition: Serial Optical Coherence口頭発表（一般）
- 第23回日本心血管インターベンション治療学会, 2014年07月, 英語, 日本心血管インターベンション治療学会, 名古屋, 国内会議Everolimus-eluting stent留置直後のOCT所見と留置9ヶ月後における新生内膜被覆への影響をみた、OCTによる連続観察研究口頭発表（一般）
- 第23回日本心血管インターベンション治療学会, 2014年07月, 日本語, 日本心血管インターベンション治療学会, 名古屋, 国内会議Angiographic Band Appearance is Associated with Smaller Reduction of Pressure Gradient Following Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertensionポスター発表
- 日本循環器学会, 2014年03月, 英語, 日本循環器学会, 東京, 国内会議Tissue characteristics of jailed strut following single stenting to bifurcation lesions: Optical coherence tomography assessment among four drug-eluting stents口頭発表（一般）
- 日本循環器学会, 2014年03月, 英語, 日本循環器学会, 東京, 国内会議The impact of atherogenic neointima on long-term clinical outcomes: an observational study from the optical coherence tomography registry口頭発表（一般）
- ACC2014, 2014年03月, 英語, American College of Cardiology, ワシントン, 米国, 国際会議Long-term Clinical Impact of Thin-cap Fibroatheroma Assessed by Optical Coherence Tomography and Virtual Histology Intravascular Ultrasound Analysis.ポスター発表
- 第78回日本循環器学会総会, 2014年03月, 英語, 日本循環器学会, 東京, 国内会議Improvement of Cardiac Output after Balloon Pulmonary Angioplasty Depends on Preoperative Right Ventricular Function in inoperable Chronic Thromboembolic Pulmonary Hypertensionポスター発表
- 日本循環器学会, 2014年03月, 日本語, 日本循環器学会, 東京, 国内会議Impact of Stent-platform on Wall Shear Stress Distributions:Insights from Computational Fluid Dynamics Simulations Using OCT and CTA Fusion Imagesシンポジウム・ワークショップパネル（公募）
- 日本循環器学会, 2014年03月, 日本語, 日本循環器学会, 東京, 国内会議Impact of Daily Glucose Fluctuation on Coronary Plaque Vulnerability in Patients Pretreated With Lipid Lowering Therapyシンポジウム・ワークショップパネル（公募）
- ACC2014, 2014年03月, 英語, American College of Cardiology, ワシントン, 米国, 国際会議Impact of Daily Glucose Fluctuation on Coronary Plaque Vulnerability in Patients Pretreated With Lipid Lowering Therapyポスター発表
- 日本循環器学会, 2014年03月, 英語, 日本循環器学会, 東京, 国内会議Favorable Vessel Healing after Nobori Biolimus A9 Eluting Stent Implantation: 6- and 12-month Follow-up by Optical Coherence Tomographyポスター発表
- ACC2014, 2014年03月, 英語, American College of Cardiology, ワシントン, 米国, 国際会議Comparisons of Early Phase Arterial Reaction after 2nd generation Drug-Eluting and Bare-Metal Stents Implantation in Patients with ST-Segment Elevation Myocardial Infarction: 2-Week Observations of Optical Coherence Tomography Evaluationポスター発表
- 日本肺高血圧学会, 2013年10月, 日本語, 日本肺高血圧学会, 東京, 国内会議慢性肺血栓塞栓症 (CTEPH)治療におけるバルーン肺動脈形成術 (BPA)の位置づけと治療手技の実際シンポジウム・ワークショップパネル（公募）
- 日本心血管内視鏡学会, 2013年10月, 日本語, 日本心血管内視鏡学会, 久留米, 国内会議Everolimus-eluting stent留置直後のOCT所見とTroponin I上昇との関連、ならびに留置9か月後における新生内膜被覆への影響の検討口頭発表（一般）
- TCT(Transcatheter Cardiovascular Therapeutics) 2013, 2013年10月, 英語, Cardiovascular Research Foundation, サンフランシスコ, 米国, 国際会議Efficacy and Safety of Balloon Pulmonary Angioplasty for Non-operable Chronic Thromboembolic Pulmonary Hypertension in Comparison to Pulmonary Endarterectomy for Operable Patients口頭発表（一般）
- 第61回心臓病学会, 2013年09月, 日本語, 日本心臓病学会, 熊本, 国内会議慢性血栓塞栓性肺高血圧症に対する薬物治療と経皮的肺動脈バルーン形成術の治療効果の検討口頭発表（一般）
- 日本心臓病学会, 2013年09月, 日本語, 日本心臓病学会, 熊本, 国内会議慢性血栓塞栓性肺高血圧症に対する 肺動脈カテーテル形成術と血栓内膜摘除術の比較口頭発表（一般）
- 日本心臓病学会, 2013年09月, 日本語, 日本心臓病学会, 熊本, 国内会議Impact of Hemodialysis on Vessel Healing after Drug-eluting Stent Implantationシンポジウム・ワークショップパネル（公募）
- European Society of Cardiology meeting 2013, 2013年08月, 英語, European Society of Cardiology, アムステルダム, オランダ, 国際会議The Evaluation of Efficacy and Safety of Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension口頭発表（一般）
- European Society of Cardiology meeting 2013, 2013年08月, 英語, European Society of Cardiology, アムステルダム, オランダ, 国際会議Impact of Strut-vessel Distance on the persistent Incomplete Strut Apposition: Serial Optimal Coherence Tomography Analysis After 1st-generation and Everolimus-eluting Stent Stentポスター発表
- European Society of cardiology 2013, 2013年08月, 英語, 欧州心臓学会, アムステルダム, オランダ, 国際会議Hemodynamic Improvement through Beneficial Vessel Reaction Following Balloon Pulmonary Angioplasty for Distal-type Chronic Thromboembolic Pulmonary Hypertensionポスター発表
- European Society of cardiology 2013, 2013年08月, 英語, 欧州心臓学会, アムステルダム, オランダ, 国際会議Efficacy and safety of balloon pulmonary angioplasty for inoperable patients with peripheral type chronic thromboembolic pulmonary hypertension口頭発表（一般）
- European Society of Cardiology meeting 2013, 2013年08月, 英語, European Society of Cardiology, アムステルダム, オランダ, 国際会議Daily Glucose Profile Has an Impact on Coronary Plaque Character in Patients with Coronary Artery Diseaseポスター発表
- 第22回日本心血管インターベンション治療学会, 2013年07月, 英語, 日本心血管インターベンション治療学会, 神戸, 国内会議The Evaluation of Vascular Remodeling Following Balloon Pulmonary Angioplasty for Distal-type Thromboemboric Pulmonary Hypertensionポスター発表
- 第22回日本心血管インターベンション治療学会, 2013年07月, 英語, 日本心血管インターベンション治療学会, 神戸, 国内会議Neoatherosclerosis within Sirolimus-eluting Stent may Reflect the Extent of Atherosclerotic Progression in Patient with Coronary Artery Diseaseポスター発表
- 第22回日本心血管インターベンション治療学会, 2013年07月, 英語, 日本心血管インターベンション治療学会, 神戸, 国内会議Impact of Strut-vessel Distance and Plaque Characteristics on the Persistent Incomplete Strut Apposition: Serial OCT Analysis After DES Implantation口頭発表（一般）
- 第22回日本心血管インターベンション治療学会, 2013年07月, 英語, 日本心血管インターベンション治療学会, 神戸, 国内会議Impact of cytochrome P450 2C19 polymorphism and residual platelet reactivity on lesion outcome after 1st and New Generation drug-Eluting Stentシンポジウム・ワークショップパネル（公募）
- 第22回日本心血管インターベンション治療学会, 2013年07月, 英語, 日本心血管インターベンション治療学会, 神戸, 国内会議Favorable Vessel Healing after Nobori Biolimus A9 Eluting Stent Implantation 6- and 12-month Follow-up by Optical Coherence Tomography口頭発表（一般）
- 第2回日本肺循環学会学術集会, 2013年06月, 日本語, 日本肺循環学会, 東京, 国内会議慢性肺血栓塞栓症と鑑別が困難であった原発性肺血管肉腫の一例口頭発表（一般）
- 日本内科学会近畿地方会, 2013年04月, 日本語, 日本内科学会, 東京, 国内会議持続血糖モニタリングにて判明した胃切除後血糖変動が誘因の一つと考えられた急性冠症候群の一例口頭発表（一般）
- 日本内科学会総会, 2013年04月, 日本語, 日本内科学会, 東京, 国内会議Temporal Course of Vessel Healing after Everolimus-eluting Stent Implantationポスター発表
- Scientific session of Japanese Circulation Society, 2013年03月, 日本語, Japanese Circulation Society, 横浜, 国際会議慢性透析患者における血清P値と大動脈弁狭窄症の関連についての検討ポスター発表
- Scientific session of Japanese Circulation Society, 2013年03月, 英語, Japanese Circulation Society, 横浜, 国際会議Use of Coronary CT Angiography to Assess Plaque Vulnerability: A Direct Comparison to Optical Coherence Tomography口頭発表（一般）
- Scientific session of Japanese Circulation Society, 2013年03月, 英語, Japanese Circulation Society, 横浜, 国際会議The ralataionships between plaque vulnerability identified by optical coherence tomography and vascular dysfunction after stent implantationポスター発表
- Scientific session of American College of Cardiology, 2013年03月, 英語, American College of Cardiology, サンフランシスコ, 国際会議The ralataionships between plaque vulnerability identified by optical coherence tomography and vascular dysfunction after stent implantationポスター発表
- Scientific session of Japanese Circulation Society, 2013年03月, 英語, Japanese Circulation Society, 横浜, 国際会議Temporal course of vessel healing after everolimus-eluting stent implantation: Long term serial follow-up by optical coherence tomographyポスター発表
- Scientific session of Japanese Circulation Society, 2013年03月, 英語, Japanese Circulation Society, 横浜, 国際会議Temporal Course of Vessel Healing after Everolimus-eluting Stent Implantation口頭発表（一般）
- Scientific session of American College of Cardiology, 2013年03月, 英語, American College of Cardiology, サンフランシスコ, 国際会議Temporal Course of Vessel Healing after Everolimus-eluting Stent Implantation口頭発表（一般）
- Scientific session of Japanese Circulation Society, 2013年03月, 英語, Japanese Circulation Society, 横浜, 国際会議Prevalence and Determinants of Intra-Stent Thrombus after Everolimus-Eluting Stent Implantation Assessed by Angioscopy and Optical Coherence Tomographyポスター発表
- Scientific session of American College of Cardiology, 2013年03月, 英語, American College of Cardiology, サンフランシスコ, 国際会議Prevalence and Determinants of Intra-Stent Thrombus after Everolimus-Eluting Stent Implantation Assessed by Angioscopy and Optical Coherence Tomographyポスター発表
- Scientific session of Japanese Circulation Society, 2013年03月, 日本語, Japanese Circulation Society, 横浜, 国際会議Paraoxonase-1 activity is associated with clopidogrel response and intra-stent thrombus after drug-eluting stent implantation in the CYP2C19 loss-of-function polymorphism carriersポスター発表
- Scientific session of Japanese Circulation Society, 2013年03月, 日本語, Japanese Circulation Society, 横浜, 国際会議Neoatherosclerosis within Sirolimus-eluting Stent (SES) may Reflect the Extent of Atherosclerotic Progression in Patient with Coronary Artery Diseaseポスター発表
- Scientific session of Japanese Circulation Society, 2013年03月, 英語, Japanese Circulation Society, 横浜, 国際会議Impact of Strut-vessel Distance and Plaque Characteristics on Persistent Incomplete Strut Apposition:Serial Optimal Coherence Tomography Analysis after Everolimus-eluting Stent Implantation口頭発表（一般）
- Scientific session of American College of Cardiology, 2013年03月, 英語, American College of Cardiology, サンフランシスコ, 国際会議Impact of Strut-Vessel Distance and Plaque Characteristics on Persistent Incomplete Strut Apposition: Serial Optical Coherence Tomography Analysis after Everolimus-Eluting Stent Implantationポスター発表
- Scientific session of Japanese Circulation Society, 2013年03月, 英語, Japanese Circulation Society, 横浜, 国際会議Impact of eicosapentanoic acid and statin concomitant therapy on coronary thin-cap fibroatheroma: Assessment by optical coherence tomographyポスター発表
- Scientific session of Japanese Circulation Society, 2013年03月, 英語, Japanese Circulation Society, 横浜, 国際会議Impact of cytochrome P450 2C19 polymorphism on drug-eluting stent failure in patients receiving clopidogrel: A potential role of paraoxonase-1 activityシンポジウム・ワークショップパネル（公募）
- Scientific session of Japanese Circulation Society, 2013年03月, 英語, Japanese Circulation Society, 横浜, 国際会議Impact of Cytochrome P450 2C19 Loss-of-Function Polymorphism on Intra-Stent Thrombus After 1st and New Generation Everolimus-Eluting Stent Implantation口頭発表（一般）
- Scientific session of Japanese Circulation Society, 2013年03月, 英語, Japanese Circulation Society, 横浜, 国際会議Comparisons of long-term arterial healing between sirolimus-eluting stent and paclitaxel-eluting stent: Detailed analysis by optical coherence tomography口頭発表（一般）
- Scientific session of Japanese Circulation Society, 2013年03月, 英語, Japanese Circulation Society, 横浜, 国際会議Comparison of the timing of neoatherosclerosis development among bare metal stents, sirolimus-eluting stents, and paclitaxel-eluting stents口頭発表（一般）
- Scientific session of American College of Cardiology, 2013年03月, 英語, American College of Cardiology, サンフランシスコ, 国際会議Comparison of the timing of neoatherosclerosis development among bare metal stents, sirolimus-eluting stents, and paclitaxel-eluting stentsポスター発表
- 日本画像動態学会年次学術集会, 2013年01月, 英語, 日本画像動態学会, 東京, 国内会議Paclitaxel-eluting stent留置後のOCT長期フォローアップ口頭発表（一般）
- American Heart Association meeting, 2012年11月, 英語, American Heart Association, シカゴ, 国際会議Relationship between Optical Coherence Tomography (OCT), Intravascular Ultrasound Tomography (IVUS) and Pressure-Derived Fractional Flow Reserveポスター発表
- American Heart Association meeting, 2012年11月, 英語, American Heart Association, シカゴ, 国際会議Progression of Vessel Healing and Neoatherosclerosis After Sirolimus-Eluting Stent Implantation: Comparisons of Serial Optical Coherence Tomography Findings Between Mid-and Late-Phase Follow-Upポスター発表
- American Heart Association meeting, 2012年11月, 英語, American Heart Association, シカゴ, 国際会議Neoatherosclerosis within Sirolimus-Eluting Stent may Reflect the Extent of Atherosclerotic Progression in Patient with Coronary Artery Disease口頭発表（一般）
- American Heart Association meeting, 2012年11月, 英語, American Heart Association, シカゴ, 国際会議Impact of Eicosapentanoic Acid and Statin Therapy on Coronary Thin-cap Fibroatheroma: Assessment by Optical Coherence Tomography口頭発表（一般）
- American Heart Association meeting, 2012年11月, 英語, American Heart Association, シカゴ, 国際会議Impact of Cytochrome P450 2C19 loss-of-function polymorphism on Intra-Stent Thrombus After 1st and new generation everolimus eluting stent Implantation in patients Receiving Clopidogrel口頭発表（一般）
- American Heart Association meeting, 2012年11月, 英語, American Heart Association, シカゴ, 国際会議Detailed Investigation of Vascular Response between Patients with or without Diabetes Mellitus after Everolimus-eluting Stent Implantation; Optical Coherence Tomography Studyポスター発表
- American Heart Association meeting, 2012年11月, 英語, American Heart Association, シカゴ, 国際会議Comparisons of Neointima Tissue Components Between Cases with Early and Late Target Lesion Revascularization After 1St Generation Drug-Eluting Stents Implantation口頭発表（一般）
- Transcatheter Cardiovascular Therapeutics (TCT) conference 2012, 2012年10月, 英語, Transcatheter Cardiovascular Therapeutics (TCT) conference, Miami, 国際会議Efficacy and Safety of Balloon Pulmonary Angioplasty for Peripheral Type Chronic Thromboembolic Pulmonary Hypertensionポスター発表
- 第1回日本肺循環学会, 2012年09月, 日本語, 日本肺循環学会, 福岡, 国内会議慢性血栓塞栓性肺高血圧症に対する肺動脈バルーン拡張術後の肺血管リモデリングの機能的・形態学的解析口頭発表（一般）
- 第1回日本肺循環学会, 2012年09月, 日本語, 日本肺循環学会, 福岡, 国内会議肺高血圧患者における、NICaS（全身バイオインピーダンス計測法）を用いた非侵襲的心拍出量評価方法の有用性口頭発表（一般）
- 第1回日本肺循環学会, 2012年09月, 日本語, 日本肺循環学会, 東京, 国内会議心房中隔欠損症に伴う肺高血圧症に対する「treat & repair」アプローチ口頭発表（一般）
- European Society of Cardiology meeting 2012, 2012年09月, 英語, European Society of Cardiology, ミュンヘン, 国際会議Relationship between Optical Coherence Tomography (OCT), Intravascular Ultrasound Tomography (IVUS) and Pressure-Derived Fractional Flow Reserveポスター発表
- European Society of Cardiology meeting 2012, 2012年09月, 英語, European Society of Cardiology, ミュンヘン, 国際会議Paraoxonase-1 (PON1) activity is associated with clopidogrel response and intra-stent thrombus after drug-eluting stent implantation in the CYP2C19 loss-of-function polymorphism carriersポスター発表
- European Society of Cardiology meeting 2012, 2012年09月, 英語, European Society of Cardiology, ミュンヘン, 国際会議Impact of Cytochrome P450 2C19 Loss-of-function Polymorphism on Intra-stent Thrombus after Sirolimus- and Everolimus-eluting Stent Implantation Assessed by Angioscopy and Optical Coherence Tomographyポスター発表
- 第21回日本心血管インターベンション治療学会, 2012年07月, 英語, 日本心血管インターベンション治療学会, 新潟, 国内会議Long-term follow-up of sirolimus-eluting stent implanted in coronary bifurcation lesion: Insight from optical coherence tomographyポスター発表
- 第21回日本心血管インターベンション治療学会, 2012年07月, 英語, 日本心血管インターベンション治療学会, 新潟, 国内会議Impact of eicosapentanoic acid and statin therapy on coronary thin-cap fibroatheroma: Assessment by optical coherence tomography口頭発表（一般）
- 第21回日本心血管インターベンション治療学会, 2012年07月, 英語, 日本心血管インターベンション治療学会, 新潟, 国内会議Gradually developed giant right coronary artery aneurysm; a case reportポスター発表
- 第21回日本心血管インターベンション治療学会, 2012年07月, 英語, 日本心血管インターベンション治療学会, 新潟, 国内会議Controversy of final kissing inflation after single stenting to bifurcation lesion: optical coherence tomography assessment for technique and stent technologyポスター発表
- 第21回日本心血管インターベンション治療学会, 2012年07月, 英語, 日本心血管インターベンション治療学会, 新潟, 国内会議Comparisons of temporal changes in peri-stent coronary plaque components between lesions treated with bare-metal and 1st generation drug-eluting stentsポスター発表
- 第21回日本心血管インターベンション治療学会, 2012年07月, 英語, 日本心血管インターベンション治療学会, 新潟, 国内会議Clinical usefulness of Non-Invasive Cardiac System (NICaS) for measuring whole body bioimpedance to evaluate cardiac output in pulmonary hypertension patientsポスター発表
- 第21回日本心血管インターベンション治療学会, 2012年07月, 英語, 日本心血管インターベンション治療学会, 新潟, 国内会議Bosentan, Sildenafil therapy and ASD closure with Amplatzer Septal Occluder in a patient with severe pulmonary hypertensionポスター発表
- 第21回日本心血管インターベンション治療学会, 2012年07月, 英語, 日本心血管インターベンション治療学会, 新潟, 国内会議A case with recurrent peri-stent contrast staining after recanalization of sirolimus-eluting stent occlusion口頭発表（一般）
- 第76回 日本循環器学会学術集会, 2012年03月, 英語, 第76回 日本循環器学会学術集会, 福岡, 国内会議Uniform Vessel Healing after Everolimus-eluting Stent implantation: Detailed Comparison with Paclitaxel-eluting Stent by Optical Coherence Tomographyシンポジウム・ワークショップパネル（公募）
- 第76回 日本循環器学会学術集会, 2012年03月, 英語, 第76回 日本循環器学会学術集会, 福岡, 国内会議The Relationship between Culprit Plaque Characters and the Microvascular Resistance: Detaled Assessment by iMAPTM and Pressure Measurement口頭発表（一般）
- ACC12 i2, 2012年03月, 英語, ACC12 i2, シカゴ, アメリカ, 国際会議The Impact Of Paraoxonase 1 Activity On The Incidence Of Intra Stent Thrombus After Drug Eluting Stent Implantation In The 日本語 Cyp2c19 Loss Of Function Polymorphism Carriers口頭発表（一般）
- ACC12 i2, 2012年03月, 英語, ACC12 i2, シカゴ, アメリカ, 国際会議The Impact Of Mid-term Oct Findings On Long-term Clinical Events After Drug-eluting Stents Implantation口頭発表（一般）
- ACC12 i2, 2012年03月, 英語, ACC12 i2, シカゴ, アメリカ, 国際会議Serial Oct And Histopathology Analysis Following 1st And New Generation Drug Eluting Stents Implantation In Swine Coronary Artery口頭発表（一般）
- 第76回 日本循環器学会学術集会, 2012年03月, 英語, 第76回 日本循環器学会学術集会, 福岡, 国内会議Relationship between Optical Coherence Tomography (OCT), Intravascular Ultrasound Tomography (IVUS) and Pressure-Derived Fractional Flow Reserve口頭発表（一般）
- ACC12 i2, 2012年03月, 英語, ACC12 i2, シカゴ, アメリカ, 国際会議Optical Coherence Tomography Assessment of Histopathology after 1st and 2nd Generation Drug-Eluting Stent Implant in Pig Coronary Model口頭発表（一般）
- 第76回 日本循環器学会学術集会, 2012年03月, 英語, 第76回 日本循環器学会学術集会, 福岡, 国内会議OCT Assessment of In-stent Restenosis and Its Impact on the Treatment Outcome口頭発表（一般）
- ACC12 i2, 2012年03月, 英語, ACC12 i2, シカゴ, アメリカ, 国際会議Neointimal Coverage of Jailed Strut Following Single Stenting to Bifurcation: Optical Coherence Tomography Assessment for 3 Types of Drug-eluting stents口頭発表（一般）
- 第76回 日本循環器学会学術集会, 2012年03月, 英語, 第76回 日本循環器学会学術集会, 福岡, 国内会議In-vivo Assessment of Neoatherosclerosis after Sirolimus-eluting Stent implantation: Comparisons of Serial Optical Coherence Tomography Findings between Early and Late Follow-up口頭発表（一般）
- ACC12, 2012年03月, 英語, ACC12, シカゴ, アメリカ, 国際会議Investigation of vascular response between patients with or without diabetes mellitus after everolimus-eluting stent implantation; optical coherence tomography study口頭発表（一般）
- 第76回 日本循環器学会学術集会, 2012年03月, 英語, 第76回 日本循環器学会学術集会, 福岡, 国内会議Impact of Mid-term OCT Findings on Long-term Clinical Events after Drug-eluting Stents Implantation口頭発表（一般）
- ACC12 i2, 2012年03月, 英語, ACC12 i2, シカゴ, アメリカ, 国際会議Impact Of Hemodialysis On Vessel Healing After Drug-eluting Stent Implantation口頭発表（一般）
- 第76回 日本循環器学会学術集会, 2012年03月, 英語, 第76回 日本循環器学会学術集会, 福岡, 国内会議Impact of Hemodialysis on Vessel Healing after Drug-eluting Stent Implantation口頭発表（一般）
- 第76回 日本循環器学会学術集会, 2012年03月, 英語, 第76回 日本循環器学会学術集会, 福岡, 国内会議Impact of Genotype of Clopidgrel Resistance on Lesion Outcome after Drug-eluting Stent Implantation in 日本語: An Optical Coherence Tomography Analysisシンポジウム・ワークショップパネル（公募）
- 第76回 日本循環器学会学術集会, 2012年03月, 英語, 第76回 日本循環器学会学術集会, 福岡, 国内会議Detailed Investigation of Vascular Response between Patients with or without Diabetes Mellitus after Everolimus-eluting Stent Implantation; Optical Coherence Tomography Study口頭発表（一般）
- 第76回 日本循環器学会学術集会, 2012年03月, 英語, 第76回 日本循環器学会学術集会, 福岡, 国内会議Assessment of Neoatherosclerosis after Sirolimus-eluting Stents Using Angioscopy and Optical Coherence Tomography口頭発表（一般）
- 第18回日本心血管インターベンション治療学会 近畿地方会, 2012年02月, 日本語, 第18回日本心血管インターベンション治療学会 近畿地方会, 大阪, 国内会議心房中隔欠損症に対するAmplatzer Septal Occluderによる閉鎖術を施行した13症例の検討口頭発表（一般）
- TCT2011, 2011年11月, 英語, TCT2011, シカゴ, アメリカ, 国際会議Uniform Vessel Healing after Everolimus-eluting Stent Implantation:口頭発表（一般）
- TCT2011, 2011年11月, 英語, TCT2011, シカゴ, アメリカ, 国際会議Long-term follow-up of sirolimus-eluting stent implanted in coronary bifurcation lesion:口頭発表（一般）
- TCT2011, 2011年11月, 英語, TCT2011, シカゴ, アメリカ, 国際会議In-vivo Assessment of Neoatherosclerosis after Sirolimus-eluting Stent Implantation: Comparisons of口頭発表（一般）
- ・TCT 2011, 2011年11月, 英語, TCT 2011, シカゴ, アメリカ, 国際会議Impact of Stent Platform of Paclitaxel-eluting Stents: Detailed Assessment of Neointimal Distribution by Optical Coherence Tomography口頭発表（一般）
- TCT2011, 2011年11月, 英語, TCT2011, シカゴ, アメリカ, 国際会議Elevated Pre-procedural High-sensitive CRP Levels are Associated with Uneven Vessel Healing after Paclitaxel-eluting Stents Implantation in Patients with Stable Angina口頭発表（一般）
- 第17回日本心血管インターベンション治療学会近畿地方会, 2011年10月, 日本語, 第17回日本心血管インターベンション治療学会近畿地方会, 大阪, 国内会議非薬剤溶出性ステント留置にて消失した冠動脈龍瘤を血管内超音波と光干渉断層映像法で観察し得た一例口頭発表（一般）
- 第17回日本心血管インターベンション治療学会近畿地方会, 2011年10月, 日本語, 第17回日本心血管インターベンション治療学会近畿地方会, 大阪, 国内会議OCTガイド下に、LMT bifurcationにPCIを施行した一例口頭発表（一般）
- 第254回日本小児科学会兵庫県地方会, 2011年09月, 日本語, 日本小児科学会兵庫県地方会, 姫路, 国内会議トルバプタンが心不全の改善に有効であったミオパチーに伴う拡張型心筋症の1例その他
- 第59回日本心臓病学会学術集会, 2011年09月, 英語, 第59回日本心臓病学会学術集会, 神戸, 国内会議OCT-based approaches for the evaluation of DES: now and the futureシンポジウム・ワークショップパネル（公募）
- 第20回日本心血管インターベンション治療学会, 2011年07月, 英語, 日本心血管インターベンション治療学会, 大阪, 国内会議The comparison between frequency domain optical coherence tomography and intravascular ultrasound after stent implantation口頭発表（一般）
- 第20回日本心血管インターベンション治療学会, 2011年07月, 英語, 日本心血管インターベンション治療学会, 大阪, 国内会議Natural consequence of stent malapposition tissue prolapse and thrombus assessed by optical coherence tomographyポスター発表
- 第20回日本心血管インターベンション治療学会, 2011年07月, 英語, 日本心血管インターベンション治療学会, 大阪, 国内会議Detailed assessment of plaque components susceptible to slow flow phenomenon: insights from iMAP analysis口頭発表（一般）
- 第20回日本心血管インターベンション治療学会, 2011年07月, 英語, 日本心血管インターベンション治療学会, 大阪, 国内会議Assessment of debulking effect of rotational atherectomy using frequency domain type optical coherence tomography (C7-OCT)口頭発表（一般）
- 第20回日本心血管インターベンション治療学会, 2011年07月, 英語, 日本心血管インターベンション治療学会, 大阪, 国内会議A novel radiofrequency signal analysis for coconary plaque characterization at culprit lesion using iMAP口頭発表（一般）
- 第20回日本心血管インターベンション治療学会, 2011年07月, 英語, 日本心血管インターベンション治療学会, 大阪, 国内会議A case with spontaneous coronary dissection which entry point was detected by frequency domain OCT.口頭発表（一般）
- 第20回日本心血管インターベンション治療学会, 2011年07月, 英語, 日本心血管インターベンション治療学会, 大阪, 国内会議A case of nine months follow-up optical coherence tomography examination for thin cap fibroatheroma with lipid-lowering therapy口頭発表（一般）
- 60Th American College of Cardiology, 2011年04月, 英語, American College of Cardiology, New Orleans, アメリカ, 国際会議Potential Benefit of Final Kissing Inflation after Single Stenting to Bifurcation Lesions: Difference of Optical Coherence Tomography Findings in Sirolimus and Paclitaxel-Eluting Stentsポスター発表
- 60Th American College of Cardiology, 2011年04月, 英語, American College of Cardiology, New Orleans, アメリカ, 国際会議Natural Consequence of Stent Malaposition Assessed by Optical Coherence Tomographyポスター発表
- 60Th American College of Cardiology, 2011年04月, 英語, American College of Cardiology, New Orleans, アメリカ, 国際会議Influence of Proton Pump Inhibitors (PPIs) on the Formation of Intra-Stent Thrombus in Japanese Patients Receiving Clopidogrel with or without Cytochrome P450 2c19*2 Polymorphismポスター発表
- 60Th American College of Cardiology, 2011年04月, 英語, American College of Cardiology, New Orleans, アメリカ, 国際会議Impact Of Cytochrome P450 2c19*2 Polymorphism On The Target Lesion Outcome After Drug-eluting Stent Implantation In Japanese Patients Receiving Clopidogrel.ポスター発表
- 60Th American College of Cardiology, 2011年04月, 英語, American College of Cardiology, New Orleans, アメリカ, 国際会議Assessment of Yellow Neointima and Mural Thrombi after 1st Generation Sirolimus-Eluting Stents Using Angioscope and Optical Coherence Tomographyポスター発表
- 60Th American College of Cardiology, 2011年04月, 英語, American College of Cardiology, New Orleans, アメリカ, 国際会議A Novel Radiofrequency Signal Analysis for Coronary Plaque Characterization at Culprit Lesion Using ImapTM: How Can We Use the New Parameter: Confidence Level?ポスター発表
- 第75回日本循環器学会総会・学術集会, 2011年03月, 英語, 日本循環器学会, 横浜, 国内会議Vulnerable plaque evaluation by intravascular ultrasound and optical coherence tomographyシンポジウム・ワークショップパネル（公募）
- 第16回日本心血管インターベンション治療学会, 2011年02月, 日本語, 日本心血管インターベンション治療学会, 大阪, 国内会議DES留置後再狭窄を繰り返したクロピドグレル抵抗性の一例口頭発表（一般）
- European Society of Cardiology 2010, 2010年09月, 英語, European Society of Cardiology, ストックホルム, スウェーデン, 国際会議Factor analysis of neointimal coverage after sirolimus-eluting stents implantation in patients with stable coronary artery diseaseポスター発表
- Transcatheter Cardiovascular Therapeutics TCT2010, 2010年09月, 英語, Transcatheter Cardiovascular Therapeutics TCT, ワシントン, アメリカ, 国際会議Assessment of yellow neointima and mural thrombi after 1st generation sirolimus-eluting stents using angioscope and optical coherence tomographyポスター発表
- 第74回日本循環器学会総会, 2010年03月, 日本語, 日本循環器学会, 京都, 国内会議Evaluation of taxus liberte stent by using optical coherence tomography in comparison with taxus express stentポスター発表
- 第72回日本循環器学会総会・学術総会, 2008年03月, 日本語, 日本循環器学会, 福岡, 国内会議Reliability of non-invasive cardiac output measurement (NICaSTM) in outpatients monitoringポスター発表
- 第72回日本循環器学会, 2008年03月, 日本語, 日本循環器学会, 福岡, 国内会議Delayed Neointimalization on Sirolimus-eluting Stents Located at a Major Side Branch Orfice – Evaluation by Optical Coherence Tomographyポスター発表
- 第72回日本循環器学会, 2008年03月, 日本語, 日本循環器学会, 福岡, 国内会議Clinical Features of Plaque Progression in patients with Stable Angina: Binary Intravascular Ultrasound Virtual Histology Study.口頭発表（一般）
- 第72回日本循環器学会, 2008年03月, 日本語, 日本循環器学会, 福岡, 国内会議Can virtual histology intravascular ultrasound in vivo?口頭発表（一般）
- 第55回日本心臓病学会学術集会, 2007年09月, 日本語, 日本心臓病学会, 東京, 国内会議非侵襲的心拍出量測定システム（NICaS)を用いた外来慢性心不全患者の評価～運動耐容能、血漿BNP濃度との比較～ポスター発表
- 第55回日本心臓病学会学術集会, 2007年09月, 日本語, 日本心臓病学会, 東京, 国内会議冠動脈プラークが退縮する症例における血中アディポネクチン値および冠動脈プラーク性状の変化：Virtual Histology IVUSによる検討口頭発表（一般）
- 第55回日本心臓病学会学術集会, 2007年09月, 日本語, 日本心臓病学会, 東京, 国内会議Thin-cap fibroatheroma progressionの一連の変化をVH-IVUSとOCTにて観察しえた一例口頭発表（一般）
- EuropeanSocietyofCardiovascular, 2007年09月, 英語, European Society of Cardiovascular, ウィーン, Austria, 国際会議Evoluationof delayed tissue coverage on sirolimus ?eluting stents from six ?months to twelve-month-optical coherence tomography studyポスター発表
- ヨーロッパ心臓病学会ＥＳＣ2007, 2007年09月, 英語, ヨーロッパ心臓病学会, Vienna, オーストリア, 国際会議Effect of pioglitazone on coronary plaque volume and components in patients with type 2 diabetes: intravascular ultrasound virtual histology study口頭発表（一般）
- 第55回日本心臓病学会学術集会, 2007年09月, 日本語, 日本心臓病学会, 東京, 国内会議Cypher stent留置2年以上後にvery late thrombosis をきたした症例を発症前後に光干渉断層法（OCT）にて観察しえた一例口頭発表（一般）
- ヨーロッパ心臓病学会ＥＳＣ2007, 2007年09月, 英語, ヨーロッパ心臓病学会, Vienna, オーストリア, 国際会議Coronary plaque regression is closely related to the decrease of necrotic core with increase of plasma adiponectin level: 6-month binary studies with virtual histology intravascular ultrasoundポスター発表
- 第17回日本心血管インターベンション学会学術集会, 2007年06月, 英語, 日本心血管インターベンション学会, 福島県, 国内会議低左心機能、心室頻拍を繰り返す重症多枝疾患症例にPCIを施行し心機能回復を非侵襲的経時的に観察し得た一例ポスター発表
- 日本学術振興会, 科学研究費助成事業, 基盤研究(B), 神戸大学, 2023年04月01日 - 2026年03月31日動脈硬化性疾患シングルセルアトラスの作成とゲノム統合解析による発症メカニズム解明本研究の目的は、動脈硬化性疾患（冠動脈疾患CAD、大動脈瘤AA、大動脈弁狭窄症AS）のシングルセルアトラスの作成と全ゲノム解析を行い、トランスオミックス統合解析を行うことで、それぞれの疾患の相違点を炙り出し、疾患のリスク層別化を行い、発症メカニズムを解明することである。本研究では、これら3疾患について、1）病変部のシングルセル＋核RNAシークエンス（scRNAseq+snRNAseq）からシングルセルアトラスを作成、各々の疾患特異的マクロファージの同定を行うと同時に、2）T細胞レパトア解析から各々の疾患において、特徴的な抗原が存在するのかを明らかにする。さらには、3）Genotyping of Transcriptomes (GoT)による シングルセルレベルで骨髄のクローン性造血の関与を調べる解析と4）全ゲノム解析による遺伝素因とトランスクリプトームの関連を解析する、expression quantitative locus (eQTL)解析を行う。3)と4)の実施にて、ゲノム・トランスクリプトーム統合解析が達成できる。すでに、3疾患の少数サンプルでのシングルセルトランスクリプトーム解析は終了し、シングルセルアトラスの概要は見えてきている。CADでT細胞受容体レパトア解析が終了し論文報告を行った。AAでは、結果を受けマウスでの実験も同時実施しており、マクロファージやB細胞での疾患特異的な特徴のデータを得ている。ASでのクローン性造血(CH)の原因となる体細胞遺伝子変異の解析数を増加させており、少数患者でのGoT解析を進めている。まずは3)GoTの統合解析手法の確立を目指す。全ゲノム解析は実施できておらず、4)eQTLの実施までには、さらに時間が必要と考えられる。
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2021年04月01日 - 2024年03月31日冠動脈プラーク内部に発生する応力評価を用いた高リスクプラーク同定の試み我々は数値流体力学解析(Computational Fluid Dynamic: CFD）を用いてプラーク外だけではなくプラーク内部から発生する機械的ストレス(plaque structural stress: PSS)を定量化する新たな手法を確立し、プラークの不安定化や破綻との関連を検討することを目的に本検討課題に取り組んでいる。これまで申請者らは、光干渉断層影像法(Optical coherence tomography: OCT)画像からCFDを用いて算出した様々な血行力学的因子が、プラークの破綻部位や破綻様式と関連することを報告してきた。しかしOCTのみで作成した3D血管モデルでは血管の屈曲やねじれを反映できず、PSSの評価は困難であった。また剪断力やWall shear stressを検討する際にも、OCTだけを用いた血管を直線化したこれまでのモデルでは、正確な評価が難しく、ひいては信頼度の高い心血管イベント予測は困難であることが予想された。そこで本検討課題では、まず最初のステップとして2方向の血管造影により構築した3D血管モデルにOCT画像を融合させる方法を確立すべく検討を開始した。現在まで、5例の血管造影、OCTを施行された患者のデータを用いて、2方向の血管造影により構築した3D血管モデルにOCT画像を融合させる方法に関する検討を行い、スムーズな解析の進行と、その方法論を確立するに至っている。その過程で愛媛大学理工学科機械工学講座:保田和則教授や愛媛大学医学部附属病院、清家史靖医師と、定期的にweb会議を施行、助言を頂きながら順調な計画の進行を認めている。今後はADINA 8.6.1 (ADINA R&D, Inc., USA)を用いてプラークにかかる剪断力やWSS, PSSを解析する方法を確立するべく実際の症例を追加し検討を行う予定である。
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2018年04月01日 - 2021年03月31日2018年度にはLGEMRIを用いて同定した心房繊維化領域への高周波通電の効果について、良好な反応（心房細動停止ないし他の心房性不整脈への移行）を認める場合の特徴を明らかにすることができました。①一定の信号強度を有する（＞2SD)に加えて、②まだらな分布をしている（entropyが高い）ことが必須条件となります。低電位領域は心房細動器質として注目されておりましたが、LGEMRIで同定された領域はさらに特異度が高くより効率的な心房細動アブレーションが可能となる事を確認できました。 2019年度は、同手法を用いて個々の心房細動基質に直接的に治療を行う、いわゆるテーラーメイド治療を確立し前向きに治療介入を行いました。最終アブレーション１年後の長期成績についても通常アブレーション法（肺静脈隔離術）に比して良好な成績を得ることを確認できました。本成果は2020年3月に開催予定であった第84回日本循環器学会学術集会で発表予定でした。またLGEMRIを用いた治療創の評価についても研究を行い、原著論文として受理されております。（J Cardiovasc Electrophysiol. 2019 Oct;30(10):1830-1840）また炎症分布の視覚化については、前向き介入研究を行い、PETMRIの撮像プロトコールの確立を目指しております。現時点では、治療により形成された強い心房炎症についてはPETMRIで視覚化できることが確認できました。同研究成果については近日中に論文投稿を予定しております。また初年度のプロトコール論文（Circ Rep 2019; 1: 149 - 152 doi: 10.1253/circrep.CR-19-0003）に基づきPETMRIを用いて心房炎症の視覚化の確立を行っております。治療創に認める強力な心房炎症はPETMRIによる視覚化に成功しており、本成果は論文として投稿準備をしております。競争的資金
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2015年04月01日 - 2018年03月31日, 研究代表者虚血性心疾患の原因となる不安定なプラークは、種々の血行力学的因子と関連し発生することを明らかにした。また、ステント治療後の患者を対象にした検討では、従来指摘されてきたwall shear stressのみでなく、wall shear stressのかかる持続時間やその変化がその後の血管修復に影響を及ぼしていることが明らかになった。これらの因子を組み合わせることでより効果的な動脈硬化の予防や、安全なステント治療後の管理が行える可能性が示唆された。競争的資金