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長谷川 巧実大学院医学研究科 医科学専攻准教授
研究活動情報
■ 受賞- 2018年11月 第63回日本口腔外科学会総会・学術大会, 優秀口演発表賞, 効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果国内学会・会議・シンポジウム等の賞
- 2007年09月 第37回日本口腔インプラント学会, 学会賞(デンツプライ賞)受賞, β-リン酸三カルシウム(β-TCP)内への骨髄幹細胞(BMSC)導入方法と骨形成能の検討国内学会・会議・シンポジウム等の賞
- OBJECTIVES: The effects of systemic inflammation on the temporomandibular joint (TMJ) are poorly understood. This study aimed to establish a mouse model to study the effects of systemic inflammation on the TMJ. MATERIALS AND METHODS: SKG mice, a BALB/c strain with spontaneous onset of rheumatoid arthritis-like symptoms due to a spontaneous point mutation (W163C) in the gene encoding the SH2 domain of ZAP-70, were treated with zymosan (β-1,3-glucan). Synovitis, bone erosion, and cartilage damage in the TMJ were evaluated using established scores for animal models of inflammatory arthritis. Myeloperoxidase-positive areas and numbers of tartrate-resistant acid phosphatase (TRAP)-positive cells were compared between naive and zymosan-treated SKG mice. Correlations between TMJ inflammation scores and clinical scores for extremities were also assessed. RESULTS: There were significant differences in TMJ inflammation scores, including synovitis, bone erosion, and cartilage damage, between naive and high-dose zymosan-treated mice. There were significant differences in myeloperoxidase-positive areas and numbers of TRAP-positive cells between naive and zymosan-treated mice. There were significant correlations between TMJ inflammation scores and clinical scores for extremities. CONCLUSIONS: Systemic administration of zymosan efficiently induces TMJ inflammation in SKG mice. Zymosan-treated SKG mice offer a useful tool to investigate the effects of systemic inflammation on the TMJ.2024年12月, Oral diseases, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: The pathological evaluation of cancellous bone at resection margins of mandibular osteoradionecrosis (ORN) has not been well elucidated. Here, we developed a unique classification system for evaluating the degree of bone marrow fibrosis, one of most common pathological features, in patients with mandibular ORN, based on which we investigated its relationship with treatment outcome. METHODS: This study included 15 patients who underwent mandibulectomy and free fibula osteocutaneous flap reconstruction. The extent of mandibulectomy was determined, with safety margins of approximately 10 mm from the apparent osteolytic areas on preoperative computed tomography image. Special staining was performed on thin sections from center of the osteolytic areas (medial area) and bilateral resection margins, and the degree of bone marrow fibrosis was evaluated and investigated its relationship with presence of bone union as a treatment outcome. RESULTS: The degree of bone marrow fibrosis of medial area was significantly higher than those of resection margins. Although most resection margins had collagen fibers which indicate severe fibrosis, all transferred fibula flaps achieved bone union. CONCLUSION: When mandibulectomy is performed with safety margins of approximately 10 mm from the apparent osteolytic areas, all transferred fibula flaps achieved bone union regardless of the degree of bone marrow fibrosis at resection margin. In other words, the association between severe bone marrow fibrosis at resection margins and treatment outcome was not seen. CLINICAL RELEVANCE: Setting safety margins of approximately 10 mm may achieve bone union, but further study is needed.2024年11月, Clinical oral investigations, 28(11) (11), 626 - 626, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Mandibular wisdom teeth can occasionally cause infections, which can progress to severe deep neck infections (DNIs) including deep neck abscesses or necrotizing soft tissue infections, which are fatal. This study aimed to identify the radiographic characteristics of mandibular wisdom teeth that developed severe DNIs. METHODS: This study included patients who were admitted for the treatment of severe mandibular wisdom tooth infection between July 2012 and June 2024 at a single center. Patient characteristics, clinical data, and radiographic findings were analyzed and compared between the severe DNI group and mild DNI group including patients with cellulitis or superficial abscess. P < 0.05 was considered significant. RESULTS: Nineteen of 42 patients (45.2%) were included in the severe DNI group. The multivariate analysis showed that the highest odds ratio (OR) was for the presence of a radicular cyst (OR=17.7), followed by the presence of a dentigerous cyst (OR =14.5). The most common mandibular wisdom tooth with a dentigerous cyst in patients with severe DNIs was inverted according to Winter's classification and type IIIC in the Pell and Gregory classification. CONCLUSION: Radiographic characteristics associated with severe DNIs included the presence of radicular and dentigerous cysts in the mandibular wisdom teeth. Especially in dentigerous cysts, deeply impacted teeth should be taken attention.2024年10月, Cureus, 16(10) (10), e70791, 英語, 国際誌研究論文（学術雑誌）
- (NPO)日本口腔科学会, 2024年09月, 日本口腔科学会雑誌, 73(2) (2), 113 - 113, 日本語ヒト下歯槽神経のバリア制御に関連する分子の解析
- (NPO)日本口腔科学会, 2024年09月, 日本口腔科学会雑誌, 73(2) (2), 216 - 216, 日本語歯の喪失は65歳高齢者の早期要介護発生リスクと関係するか?
- PURPOSE: Medication-related osteonecrosis of the jaw (MRONJ) occasionally occurs following tooth extractions in cancer patients receiving denosumab (Dmab). However, there are currently no established guidelines for perioperative antibiotic administration during tooth extraction in these patients. The primary objective was to develop guidelines for the dose and frequency of antibiotics during tooth extraction by investigating the correlation between the current status of antibiotic administration and the development of MRONJ. METHODS: This study included 68 cancer patients receiving high-dose Dmab who had tooth extractions between 2012 and 2022 at 10 hospitals. The relationship between the way of perioperative antibiotic administration and the development of MRONJ was analyzed. A P-value < .05 was considered significant. RESULTS: There was considerable variability across hospitals and surgeons regarding the type, dosage, and duration of antibiotic administration. Amoxicillin (AMPC) was the most commonly used antibiotic. Focusing exclusively on teeth extracted under AMPC administration, MRONJ developed in 21 out of 123 teeth (17.0%). No significant relationship was found between the development of MRONJ and the dosage or duration of perioperative AMPC administration. CONCLUSION: Perioperative antibiotic administration alone may not be sufficient to prevent MRONJ. Therefore, a single preoperative dose is likely adequate for effective and appropriate AMPC administration. .2024年08月, Cureus, 16(8) (8), e67237, 英語, 国際誌研究論文（学術雑誌）
- Springer Science and Business Media LLC, 2024年05月, International Journal of Clinical Oncology, 29(8) (8), 1122 - 1132研究論文（学術雑誌）
- 2024年04月, Surgery (United States), 175(4) (4), 1128 - 1133研究論文（学術雑誌）
- BACKGROUND: Pancreaticoduodenectomy has been associated with a high mortality rate and significant postoperative morbidity. Recently, perioperative oral care management has been reported to be effective in preventing postoperative pneumonia and surgical site infection. In this study, we examined the effect of perioperative oral care management in reducing complications after pancreaticoduodenectomy, including surgical site infection. METHODS: This retrospective multicenter study included 503 patients who underwent pancreaticoduodenectomy at 8 facilities between January 2014 and December 2016. Among these, 144 received perioperative oral management by dentists and dental hygienists (oral management group), whereas the remaining 359 did not (control group). The oral care management program included oral health instructions, removal of dental calculus, professional mechanical tooth cleaning, removal of tongue coating, denture cleaning, instructions for gargling, and tooth extraction. The participants were matched using propensity scores to reduce background bias. Various factors were examined for correlation with the development of complications. RESULTS: The incidence of organ/space surgical site infection was significantly lower in the oral management group than in the control group (8.0% vs 19.6%, P = .005). Multivariable logistic regression analysis revealed that hypertension and lack of perioperative oral management were independent risk factors for organ/space surgical site infection. Lack of perioperative oral management had an odds ratio of 2.847 (95% confidence interval 1.335-6.071, P = .007). CONCLUSION: Perioperative oral care management reduces the occurrence of surgical site infections after pancreaticoduodenectomy and should be recommended as a strategy to prevent infections in addition to antibiotic use.2024年04月, Surgery, 175(4) (4), 1128 - 1133, 英語, 国際誌研究論文（学術雑誌）
- Introduction In our previous work, we investigated the analgesic effects of ibuprofen gargle after mandibular third molar extractions. However, a subsequent detailed review of individual patient data revealed variations in postoperative pain reduction among patients. Consequently, the present study was designed to conduct post-hoc subanalyses that identified factors contributing to variation in the analgesic response to ibuprofen gargle after third molar extractions. Materials and methods This study involved thirty-five Japanese patients from a prior randomized, double-blind, placebo-controlled, crossover study, which focused on the analgesic effects of ibuprofen gargle after mandibular third molar extractions. Participants were categorized as responders (n = 13) and non-responders (n = 22) based on the within-subject difference (ibuprofen-placebo, IP) of visual analog scale (VAS) changes. Baseline characteristics were compared, along with variables, such as age, sex, the reason for extraction, extraction site, Pell Gregory (space and depth) classification, Winter's classification, surgeon's experience, and surgery time. Baseline characteristics predicting responder status were examined using multivariate logistic regression. Results In the univariate analysis, variables such as age, sex, and baseline VAS scores with p-values <0.2 were evaluated using a stepwise approach. This analysis identified age (per -10 years) with an odds ratio of 4.163 (95% confidence interval (CI): 1.170-31.952, p = 0.0233) and sex (female) with an odds ratio of 9.977 (95% CI: 1.336-208.256, p = 0.0213) as significant predictors of responder status. Conclusions In young and female patients, ibuprofen gargle decreased postoperative pain after mandibular third molar extractions.2024年04月, Cureus, 16(4) (4), e57516, 英語, 国際誌研究論文（学術雑誌）
- Cancer cachexia causes skeletal muscle atrophy, impacting the treatment and prognosis of patients with advanced cancer, but no treatment has yet been established to control cancer cachexia. We demonstrated that transcutaneous application of carbon dioxide (CO2) could improve local blood flow and reduce skeletal muscle atrophy in a fracture model. However, the effects of transcutaneous application of CO2 in cancer-bearing conditions are not yet known. In this study, we calculated fat-free body mass (FFM), defined as the skeletal muscle mass, and evaluated the expression of muscle atrophy markers and uncoupling protein markers as well as the cross-sectional area (CSA) to investigate whether transcutaneous application of CO2 to skeletal muscle could suppress skeletal muscle atrophy in cancer-bearing mice. Human oral squamous cell carcinoma was transplanted subcutaneously into the upper dorsal region of nude mice, and 1 week later, CO2 gas was applied to the legs twice a week for 4 weeks and FFM was calculated by bioimpedance spectroscopy. After the experiment concluded, the quadriceps were extracted, and muscle atrophy markers (muscle atrophy F-box protein (MAFbx), muscle RING-finger protein 1 (MuRF-1)) and uncoupling protein markers (uncoupling protein 2 (UCP2) and uncoupling protein 3 (UCP3)) were evaluated by real-time polymerase chain reaction and immunohistochemical staining, and CSA by hematoxylin and eosin staining. The CO2-treated group exhibited significant mRNA and protein expression inhibition of the four markers. Furthermore, immunohistochemical staining showed decreased MAFbx, MuRF-1, UCP2, and UCP3 in the CO2-treated group. In fact, the CSA in hematoxylin and eosin staining and the FFM revealed significant suppression of skeletal muscle atrophy in the CO2-treated group. We suggest that transcutaneous application of CO2 to skeletal muscle suppresses skeletal muscle atrophy in a mouse model of oral squamous cell carcinoma.2024年, PloS one, 19(4) (4), e0302194, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVES: The need for prevention and management of medication-related osteonecrosis of the jaw (MRONJ) has increased with the growing number of patients using antiresorptive agents. The scope of this systematic review (SR) was to determine whether the withdrawal of antiresorptive agents is necessary for tooth extractions in patients receiving each of the antiresorptive medications. MATERIALS AND METHODS: The searches were performed using the MEDLINE databases. We selected SRs, randomized controlled trials (RCTs), prospective and retrospective non-randomized clinical (observational) studies, and case reports/case series in this order of preference. RESULTS: We included one SR, one RCT, five observational studies, and three case reports. Meta-analyses were not conducted because the RCT had an extremely small sample size and the observational studies had different definitions of intervention and comparison that could not be integrated across studies. In this SR, no studies showed a benefit (i.e., a reduction in the incidence of osteonecrosis of the jaw) of short-term withdrawal of antiresorptive agents for tooth extraction. Additionally, no studies examined the harm (i.e., an increase in femoral and vertebral fractures and skeletal-related events during bone metastasis) of withdrawal for tooth extraction. CONCLUSIONS: We were unable to determine whether withdrawal before and after tooth extraction is necessary with a high certainty of evidence. Future systematic reviews including RCTs with larger samples are expected to provide such evidence. CLINICAL RELEVANCE: This systematic review provides evidence-based information for multidisciplinary collaborations related to patients receiving antiresorptive agents.2023年12月, Clinical oral investigations, 28(1) (1), 38 - 38, 英語, 国際誌研究論文（学術雑誌）
- Introduction: Head and neck squamous cell carcinoma (HNSCC) treatment includes surgery, radiotherapy, and immunotherapy with the aim of eradicating cancer cells without affecting normal tissues. HNSCC expresses epidermal growth factor receptor (EGFR) and cetuximab, an IgG1 monoclonal antibody targeting epidermal growth factor receptor, has been approved for the treatment of HNSCC. However, cetuximab has low reactivity and induces serious side effects. Gold nanoparticles (AuNPs) were reported to enhance the local antitumor effects of radiotherapy without damaging normal cells. Methods and Results: This study investigated the in vitro effects of single and combination therapy with AuNPs (1.0 nM), cetuximab (30 nM), and radiotherapy (4 Gy) on a human HNSCC cell line, HSC-3. Combination treatment of AuNPs + cetuximab + radiotherapy markedly reduced HSC-3 numbers and proliferation and enhanced apoptosis compared with single and double combination treatments. Furthermore, the in vivo combination treatment (AuNPs + cetuximab + radiotherapy) of a xenograft model of HSC-3 cells transplanted into nude mice (BALB/cAJcl-nu/nu) reduced the tumor volume compared with the controls. Scanning electron microscopy demonstrated the presence of AuNPs in tumor tissues and toxicity analysis indicated that AuNPs had no toxic effect on normal tissues. Conclusions: This study showed that AuNPs alone do not have a tumor-suppressing effect, but they sensitize tumors to radiotherapy and bind to cetuximab, leading to enhanced antitumor effects.MDPI AG, 2023年12月, Cancers, 15(23) (23), 5697 - 5697研究論文（学術雑誌）
- 2023年12月, Cureus, 英語研究論文（学術雑誌）
- PURPOSE: In this study, we prospectively investigated the relationship between bone marrow edema (BME) and odontogenic cysts and explored the possibility of using dual-energy computed tomography (DECT) as an auxiliary tool for the diagnosis of odontogenic cysts. METHODS: This cross-sectional study included 73 patients who underwent the DECT scan and surgery for odontogenic cysts or odontogenic tumors. The virtual noncalcium (VNCa) computed tomography (CT) values and CT values were measured at several sites. The predictor variable was diagnosis, and the other variables included age, sex, and sites. The primary outcome was VNCa CT value. Variables were tested using the chi-square test or the Kruskal-Wallis test. The VNCa CT and CT values were tested using the Scheffe test for multiple comparisons. All variables were analyzed as independent variables affecting the VNCa CT values around the lesion in the multiple regression analysis. RESULT: There were 35 men and 38 women. The mean patient age was 50.0 ± 19.5 years (range: 8-86). The VNCa CT values (- 6.2 ± 34.3) around the lesion in patients with RCs were significantly higher than those in patients with dentigerous cysts (- 44.4 ± 28.6) and odontogenic keratocysts (- 67.3 ± 19.5). In multiple regression analysis, the VNCa CT values around the lesion showed a significant positive correlation with histological results (regression coefficient: - 0.605, P < 0.001). CONCLUSION: The presence of BME is associated with radicular cysts, and DECT can be used as an auxiliary tool for radicular cyst diagnosis.2023年12月, Oral and maxillofacial surgery, 27(4) (4), 675 - 684, 英語, 国際誌研究論文（学術雑誌）
- (公社)日本口腔インプラント学会, 2023年12月, 日本口腔インプラント学会誌, 36(4) (4), E206 - E207, 日本語下顎歯肉癌腓骨皮弁再建症例におけるインプラント支持型圧迫床を用いた前庭拡張術の工夫
- OBJECTIVE: This study was designed to evaluate the postoperative efficacy and safety of using an ibuprofen gargle as a pain management strategy for patients who have undergone mandibular third molar extraction. We also ensured that the quality of treatment was not compromised throughout the study. MATERIAL AND METHODS: Patients were randomized in a 1:1 ratio into two groups: the ibuprofen-placebo (IP) group and the placebo-ibuprofen (PI) group. On postoperative Day (POD) 1, the IP group initiated ibuprofen administration, while the PI group started taking placebo. On POD 2, the IP group switched to using placebo, whereas the PI group switched to ibuprofen. From PODs 3-5, both groups were prescribed ibuprofen gargle. The primary endpoint was within-subject visual analog scale (VAS) score before and 5 min after the first use of the ibuprofen or placebo gargle on PODs 1 and 2 (ΔVAS5_ibuprofen - ΔVAS5_placebo ). The incidence and severity of adverse events were assessed using the Common Terminology Criteria for Adverse Events version 5.0 and a subjective rating scale. RESULTS: This study enrolled 40 patients. The within-subject VAS5 of the IP and PI groups were 1.25 ± 12.0 and -5.26 ± 8.93 mm, respectively. The treatment effect of ibuprofen gargle was -2.01 ± 10.62 mm (p = .246). None of the patients in each group presented with serious adverse events or clinically significant complications (including dry sockets) after extraction. Transient adverse events, such as throat tingling and oral discomfort (grade 1), were observed in each group. CONCLUSION: Ibuprofen gargle was safe but did not provide significant pain relief when used after mandibular third molar extraction.2023年11月, Clinical and experimental dental research, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVES: Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse effect of antiresorptive and/or antiangiogenic agents. As the treatment application for MRONJ is controversial, we aimed to identify the risk factors for poor prognosis and to help determine appropriate management. METHODS: This study included 119 patients. Relevant clinical data were obtained for all the patients. In computed tomography images, osteosclerosis, osteolysis, cortical perforation (buccal or lingual), periosteal reaction, and sequestration were evaluated. RESULTS: Multivariate analyses showed statistically significant associations between poor prognosis in patients with MRONJ and conservative treatment alone (hazard ratio [HR] 1.89), osteolysis (HR 4.67), and the absence of sequestration (HR 5.33). CONCLUSIONS: Conservative treatment alone without clear objectives needs to be avoided, and osteolytic change could be the criteria for surgical intervention. As the boundary between the lesion and vital bone is indistinct, we recommend extensive surgery in cases with unpredictable sequestration.2023年11月, Head & neck, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Head and neck cancers that cause severe aesthetic and functional disorders normally metastasize to the cervical lymph nodes. Patients with cervical lymph node metastasis are undergoing neck dissection. Shoulder complaints are common after neck dissection, with patients reporting symptoms such as pain, weakness, shoulder droop, and disability. However, no safe and effective treatment is available for this condition at present. We will conduct a double-blinded, randomized controlled trial to evaluate the efficacy of carbon dioxide (CO2) paste in relieving pain in patients after neck dissection. OBJECTIVE: This will be the first clinical study to compare the efficacy of CO2 paste with placebo in relieving postoperative pain in patients who underwent neck dissection. METHODS: We will perform this trial at the Kobe University Hospital in Japan. Patients will be randomized 1:1 into the CO2 paste and control groups. Patients in the CO2 paste group will have the CO2 paste applied to the cervical surface skin for 10 minutes once per day for 14 consecutive days. The primary end point of the study is a change in the visual analog scale (VAS) scores of neck pain from baseline on day 1 (preapplication) to the end of drug application (day 15). Secondary end points include changes in the following parameters from baseline on day 1 to the end of drug application (day 15) or the study (day 29): neck pain VAS score (days 1-29), grip strength (days 1-15 and 1-29), VAS scores for subjective symptoms (the feeling of strangulation, numbness, swelling, and warmth in the neck and shoulder region) for days 1-15 and 1-29, whether the VAS score improved more than 30% (days 1-15), the arm abduction test (days 1-15 and 1-29), shoulder range of motion (abduction and flexion) for days 1-15 and 1-29, occurrence of skin disorders, and occurrence of serious side effects. Periodic monitoring will be conducted for participants during the trial. This study was approved by the certified review board of Kobe University. RESULTS: The intervention commenced in May 2021 and will continue until March 2024. The collected data will provide information on the efficacy of the CO2 paste treatment. The primary end point will be compared using the Wilcoxon test, with the 1-sided significance level set at 5%. Each evaluation item will be summarized. Secondary efficacy end points will be analyzed to provide additional insights into the primary analysis. Findings based on the treatment effects are expected to be submitted for publication in 2025. CONCLUSIONS: This trial will provide exploratory evidence of the efficacy and safety of CO2 paste in relieving pain in patients after neck dissection. TRIAL REGISTRATION: Japan Registry of Clinical Trials (jRCT) identifier: jRCTs051210028; https://jrct.niph.go.jp/en-latest-detail/jRCTs051210028. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/50500.2023年11月, JMIR research protocols, 12, e50500, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: The present study developed an application using dual-energy computed tomography (DECT) focused on Cu for detecting medication-related osteonecrosis of the jaw (MRONJ). MATERIALS AND METHODS: First, we performed two types of phantom studies using a Cu wire syringe and pig mandible with Cu wire to detect Cu on DECT. Second, DECT examinations of 44 patients with MRONJ were performed to compare lesion and normal bone sites using single-energy CT, DECT-virtual non-calcium (VNCa), and DECT-Cu applications. Quantitative analyses of VNCa CT and CT values were performed, and a cut-off value was calculated using receiver operating characteristic analysis. Third, we compared the Cu content in the MRONJ and normal bone groups using inductively coupled plasma atomic emission spectroscopy (ICP-AES). RESULTS: The material-specific differences in attenuation between the two different energies enabled the accurate separation of Cu from Ca in phantom studies. The sensitivity and specificity for single-energy CT, DECT-VNCa, and DECT-Cu applications were 97.7% and 2.3%, 86.4% and 81.8%, and 88.6% and 97.7%, respectively. Thus, VNCa CT values obtained on DECT-Cu application images showed the highest area under the curve value and maximal diagnostic efficacy in differentiating lesion sites from normal bone sites. On ICP-AES analyses, the Cu content was significantly higher in the MRONJ group than in the normal bone group. CONCLUSION: DECT-Cu application demonstrated better diagnostic performance in detecting MRONJ compared with single-energy CT or DECT-VNCa.2023年11月, Journal of bone and mineral metabolism, 41(6) (6), 865 - 876, 英語, 国内誌研究論文（学術雑誌）
- (公社)日本顎顔面インプラント学会, 2023年11月, Japanese Journal of Maxillo Facial Implants, 22(3) (3), 242 - 242, 日本語当科における口腔癌癌患者の下顎の広範囲顎骨支持型装置に際し口腔前庭拡張術を要した11例
- OBJECTIVE: Although benign, ameloblastoma is a locally aggressive lesion in some patients and the development of additional treatments is needed. Verteporfin (VP) is a photosensitizer exhibiting considerable photocytotoxicity in various tumor cells. We aimed to investigate the effects of verteporfin photodynamic therapy (VP PDT) on ameloblastoma. METHODS: Eighteen patients who underwent surgery for ameloblastoma were randomly selected. We performed an immunohistochemical assessment to investigate the expression of low-density lipoprotein receptor (LDLR) and Yes-associated protein (YAP), targets of VP, in human ameloblastoma tissues and cultured human ameloblastoma cell line (HAM1). The effect of VP PDT on cell proliferation and apoptosis in HAM1 was analyzed. RESULTS: The expression of LDLR and YAP were detected in human ameloblastoma tissues and HAM1. LDLR expression was significantly higher in patients who had previously undergone surgery than in patients who were receiving it for the first time. The cytotoxic effect of the combination of low-concentration VP administration and laser irradiation was comparable to high-concentration VP administration with and without laser irradiation. The addition of laser irradiation to VP administration significantly accelerated apoptotic bleb formation compared with VP administration alone. CONCLUSION: VP PDT has the potential to become an additional treatment for large-sized ameloblastoma.2023年10月, Oral diseases, 英語, 国際誌研究論文（学術雑誌）
- 2023年10月, Osteoporosis International, 34(10) (10), 1823 - 1825研究論文（学術雑誌）
- Elsevier BV, 2023年10月, Oral Oncology, 145, 106519 - 106519研究論文（学術雑誌）
- 2023年09月, Journal of bone and mineral metabolism, 41(5) (5), 652 - 653, 英語, 国内誌
- 2023年09月, JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, 英語研究論文（学術雑誌）
- Mitochondrial dysfunction and respiratory function changes have been consistently associated with the initiation and progression of cancer. The purpose of this study was to retrospectively investigate the expression of mitochondrial tumor-suppressor and DNA-repair proteins in patients with oral squamous cell carcinoma (OSCC) and to evaluate the relationship between their expression and prognosis. We enrolled 197 patients with OSCC who underwent surgical resection between August 2013 and October 2018. Clinical, pathological, and epidemiological data were retrospectively collected from hospital records. The expression of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), mitochondrial transcription factor A, mitochondrial tumor suppressor gene 1, silent information regulator 3, and 8-hydroxyguanine DNA glycosylase was investigated using immunochemistry. The 3-year disease-specific survival (DSS) rates of patients showing positive expression of all selected proteins were significantly higher than those of patients showing a lack of expression. Multivariate analysis revealed that the expression of PGC-1α (hazard ratio, 4.684) and vascular invasion (hazard ratio, 5.690) can predict the DSS rate (p < 0.001). Low PGC-1α expression and vascular invasion are potential clinically effective predictors of the prognosis of OSCC.2023年08月, Cancers, 15(16) (16), 英語, 国際誌研究論文（学術雑誌）
- 2023年07月, Scientific reports, 13(1) (1), 11216 - 11216, 英語, 国際誌
- OBJECTIVE: This study aimed to reveal characteristic condylar movements in patients with jaw deformities. STUDY DESIGN: Thirty patients with jaw deformities before surgery were enrolled and instructed to chew a cookie during 4-dimensional computed tomography (4DCT). The distance between the most anterior and posterior positions of the bilateral condyles on 4DCT images was measured and compared among patients with different skeletal classes. Correlations between the condylar protrusion and cephalometric values were also determined. RESULTS: The distances of condylar protrusion during mastication were significantly greater in the skeletal class II group than in the skeletal class III group (P=0.0002). Significant correlations were found between the distances of condylar protrusion during mastication and the sella-nasion-B point angle (r=-0.442, P=0.015), A point-nasion-B point angle (r=0.516, P=0.004), sella-nasion plane to ramus plane angle (r=0.464, P=0.01), sella-nasion plane to occlusal plane angle (r=0.367, P=0.047), and condylion-gonion length (r=-0.366, P=0.048). CONCLUSION: Motion analysis with 4DCT images revealed that condylar movement in patients with retrognathism was larger than in patients with mandibular prognathism. Skeletal structure was therefore correlated with condylar movement during mastication.2023年07月, The Journal of craniofacial surgery, 英語, 国際誌研究論文（学術雑誌）
- (NPO)日本口腔科学会, 2023年07月, 日本口腔科学会雑誌, 72(2) (2), 158 - 158, 日本語OHATスコアは膿胸患者の3ヵ月時死亡リスク評価に有用である 傾向スコアマッチング法を用いた後ろ向き観察研究
- (NPO)日本口腔科学会, 2023年07月, 日本口腔科学会雑誌, 72(2) (2), 166 - 166, 日本語経皮的炭酸ガスペーストによるラット筋損傷モデルにおける瘢痕化防止と筋再生促進効果
- Although perineurium has an important role in maintenance of the blood-nerve barrier, understanding of perineurial cell-cell junctions is insufficient. The aim of this study was to analyze the expression of junctional cadherin 5 associated (JCAD) and epidermal growth factor receptor (EGFR) in the perineurium of the human inferior alveolar nerve (IAN) and investigate their roles in perineurial cell-cell junctions using cultured human perineurial cells (HPNCs). In human IAN, JCAD was strongly expressed in endoneurial microvessels. JCAD and EGFR were expressed at various intensities in the perineurium. In HPNCs, JCAD was clearly expressed at cell-cell junctions. EGFR inhibitor AG1478 treatment changed cell morphology and the ratio of JCAD-positive cell-cell contacts of HPNCs. Therefore, JCAD and EGFR may have a role in the regulation of perineurial cell-cell junctions.2023年06月, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 71(6) (6), 221554231182193 - 221554231182193, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: Necrotizing fasciitis as a complication of medication-related osteonecrosis of the jaw (MRONJ), which we named "ONJ-NF", has been sometimes reported. This study aimed to investigate the usefulness of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score for predicting ONJ-NF. MATERIALS AND METHODS: We included patients with acute MRONJ who required hospitalization at a single institution from April 2013 to June 2022. They were divided into two groups: patients with ONJ-NF and those with severe cellulitis as a complication of MRONJ, which we named "ONJ-SC." LRINEC scores were compared between the groups and the cut-off value of the score was set by creating a receiver operating characteristic curve. RESULTS: Eight patients with ONJ-NF and 22 patients with ONJ-SC were included. The LRINEC score was significantly higher in patients with ONJ-NF (median: 8.0 points, range 6-10 points) than in those with ONJ-SC (median: 2.5 points, range 0-6 points). A LRINEC score of ≥ 6 points had a sensitivity of 100.0%, a specificity of 77.3%, and an area under the curve of 0.97. Among 6 parameters of LRINEC score, only C-reactive protein (CRP) and white blood cell count (WBC) had significant differences between two groups. Most of the patients with ONJ-NF were rescued by antibiotic therapy and surgical drainage including debridement of necrotic tissues, but unfortunately, one patient did not survive. CONCLUSION: Our results suggested that the LRINEC score may be a useful diagnostic tool to predict ONJ-NF but valuating only CRP and WBC may be sufficient particularly in patients with osteoporosis.2023年06月, Journal of bone and mineral metabolism, 英語, 国内誌研究論文（学術雑誌）
- (公社)日本口腔外科学会, 2023年05月, 日本口腔外科学会雑誌, 69(5) (5), 233 - 240, 日本語
- (一社)日本口腔感染症学会, 2023年05月, 日本口腔感染症学会雑誌, 30(1) (1), 65 - 66, 日本語当科で新型コロナウイルス感染症に対してPCR検査を行った患者についての考察
- (一社)日本口腔ケア学会, 2023年04月, 日本口腔ケア学会雑誌, 17(3) (3), 172 - 172, 日本語歯科衛生士が口腔衛生管理を行った患者に対するCOVID-19発症状況について
- (一社)日本口腔ケア学会, 2023年04月, 日本口腔ケア学会雑誌, 17(3) (3), 229 - 229, 日本語COVID-19感染が契機と考えられたスティーブンスジョンソン症候群患者への口腔衛生管理の1例
- 2023年04月, INTERNATIONAL WOUND JOURNAL, 20(4) (4), 1151 - 1159, 英語研究論文（学術雑誌）
- In postoperative patients with head and neck cancer, scar tissue formation may interfere with the healing process, resulting in incomplete functional recovery and a reduced quality of life. Percutaneous application of carbon dioxide (CO2 ) has been reported to improve hypoxia, stimulate angiogenesis, and promote fracture repair and muscle damage. However, gaseous CO2 cannot be applied to the head and neck regions. Previously, we developed a paste that holds non-gaseous CO2 in a carrier and can be administered transdermally. Here, we investigated whether this paste could prevent excessive scarring and promote muscle regeneration using a bupivacaine-induced rat model of muscle injury. Forty-eight Sprague Dawley rats were randomly assigned to either a control group or a CO2 group. Both groups underwent surgery to induce muscle injury, but the control group received no treatment, whereas the CO2 group received the CO2 paste daily after surgery. Then, samples of the experimental sites were taken on days 3, 7, 14, and 21 post-surgery to examine the following: (1) inflammatory (interleukin [IL]-1β, IL-6), and transforming growth factor (TGF)-β and myogenic (MyoD and myogenin) gene expression by polymerase chain reaction, (2) muscle regeneration with haematoxylin and eosin staining, and (3) MyoD and myogenin protein expression using immunohistochemical staining. Rats in the CO2 group showed higher MyoD and myogenin expression and lower IL-1β, IL-6, and TGF-β expression than the control rats. In addition, treated rats showed evidence of accelerated muscle regeneration. Our study demonstrated that the CO2 paste prevents excessive scarring and accelerates muscle regeneration. This action may be exerted through the induction of an artificial Bohr effect, which leads to the upregulation of MyoD and myogenin, and the downregulation of IL-1β, IL-6, and TGF-β. The paste is inexpensive and non-invasive. Thus, it may be the treatment of choice for patients with muscle damage.2023年04月, International wound journal, 20(4) (4), 1151 - 1159, 英語, 国際誌研究論文（学術雑誌）
- Osteoradionecrosis (ORN) often results in pathological fractures through progression. We aimed to identify the risk factors for pathological fracture in patients with mandibular ORN. Seventy-four patients with mandibular ORN were included in this retrospective study. We investigated various risk factors for pathological fracture in patients with mandibular ORN, including number of mandibular teeth with a poor prognosis each at initial evaluation before radiation therapy (RT) and when fracture occurred, and the proportion of antibiotic administration period in a follow-up duration after RT. The rate of occurrence of pathological fractures in patients with mandibular ORN was 25.7%. The median of duration between RT completion and fracture occurrence was 74.0 months. We found that pathological fracture was significantly associated with a larger number of mandibular teeth with a poor prognosis at initial evaluation before RT (P = 0.024) and when fracture occurred (P = 0.009). Especially, a larger number of mandibular teeth with P4 periodontitis, in other words severe periodontal status, was related to pathological fracture in both timings. The proportion of antibiotic administration period in a follow-up duration was also significant risk factor (P = 0.002). Multivariate analyses showed statistically significant associations between pathological fracture and a larger number of mandibular teeth with a poor prognosis when fracture occurred (hazard ratio 3.669). The patient with a larger number of mandibular teeth with P4 periodontitis may have a risk of not only occurrence of ORN but resulting in pathological fracture by accumulation of infection. Surgeons should consider extraction of those teeth regardless of before/after RT if necessary for infection control.2023年04月, Scientific reports, 13(1) (1), 5367 - 5367, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: The purpose of this retrospective study was to investigate the prognosis of patients with oral cavity cancer with positive margin (PM) or close margin (CM) divided into pN- and pN+ groups. METHODS: The evaluated endpoints were local control and disease-specific survival (DSS) rates. RESULTS: Higher T classification, lymphovascular space invasion (LVSI), and older age were significant risk factors for DSS in the pN- groups. On the other hand, extranodal extension, multiple lymph node metastases, and LVSI were significant risk factors for DSS in the pN+ groups. Among the CM pN+ patients, no significant differences in the 3-year DSS were observed between the only surgery (51.9%) and adjuvant groups (53.2%). CONCLUSIONS: Higher T classification and LVSI are high-risk features more than PM or CM in the pN- groups for DSS. However, further prospective studies are needed to demonstrate the usefulness of adjuvant treatment in patients with PM or CM.2023年03月, Head & neck, 45(6) (6), 1418 - 1429, 英語, 国際誌研究論文（学術雑誌）
- Oral lichen planus (OLP) is a type of chronic and refractory stomatitis characterized by abnormal keratinization, which is often painful. There is no consensus regarding treatment options for OLP, particularly in the presence of pain. The current study protocol focuses on the short-term efficacy and long-term safety of an ibuprofen gargle for pain management in patients with OLP. Patients (n = 24) with painful OLP will be enrolled. During a crossover study period, patients in the ibuprofen–placebo (IP) group will receive an ibuprofen gargle (0.6%) on day 1, a placebo gargle on day 2, and an ibuprofen gargle on days 3–5 at least once daily. Patients in the placebo–ibuprofen (PI) group will receive a placebo gargle on day 1, an ibuprofen gargle on day 2, and an ibuprofen gargle on days 3–5 at least once daily. The primary endpoint of the crossover study period is the change in pain level as measured by a visual analogue scale score from before gargle administration to 5 min after gargle administration on days 1 and 2. The primary endpoint of the long-term extension study is assessment of long-term safety. The results of this study may support existing evidence regarding the effectiveness of ibuprofen rinses in treating OLP.MDPI AG, 2023年01月, Methods and Protocols, 6(1) (1), 7 - 7研究論文（学術雑誌）
- Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Cancer-associated fibroblasts (CAFs) are the main stromal cells in the tumor microenvironment (TME). As CAFs promote tumor progression and hypoxia in the TME, regulating the conversion of normal fibroblasts (NFs) into CAFs is essential for improving the prognosis of patients with OSCC. We have previously reported the antitumor effects of transcutaneous carbon dioxide (CO2) application in OSCC. However, the effects of reducing hypoxia in the TME remain unclear. In this study, we investigated whether CO2 administration improves the TME by evaluating CAFs marker expression. Human OSCC cells (HSC-3) and normal human dermal fibroblasts (NHDF) were coinjected subcutaneously into the dorsal region of mice. CO2 gas was applied twice a week for 3 weeks. The tumors were harvested six times after transcutaneous CO2 application. The expression of CAFs markers (α-SMA, FAP, PDPN, and TGF-β) were evaluated by using real-time polymerase chain reaction and immunohistochemical staining. The expression of α-SMA, FAP, PDPN, and TGF-β was significantly increased over time after co-injection. In the CO2-treated group, tumor growth was significantly suppressed after treatment initiation. In addition, the mRNA expression of these markers was significantly inhibited. Furthermore, immunohistochemical staining revealed a significant decrease in the protein expression of all CAFs markers in the CO2-treated group. We confirmed that transcutaneous CO2 application suppressed CAFs marker expression and tumor growth in OSCC xenograft mouse model.2023年, PloS one, 18(8) (8), e0290357, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Empyema is a life-threatening infection often caused by oral microbiota. To the best of our knowledge, no reports have investigated the association between the objective assessment of oral health and prognosis in patients with empyema. MATERIALS AND METHODS: A total of 63 patients with empyema who required hospitalization at a single institution were included in this retrospective study. We compared non-survivors and survivors to assess risk factors for death at three months, including the Renal, age, pus, infection, diet (RAPID) score, and Oral Health Assessment Tool (OHAT) score. Furthermore, to minimize the background bias of the OHAT high-score and low-score groups determined based on the cut-off value, we also analyzed the association between the OHAT score and death at 3 months using the propensity score matching method. RESULTS: The 3-month mortality rate was 20.6% (13 patients). Multivariate analysis showed that a RAPID score ≥5 points (odds ratio (OR) 8.74) and an OHAT score ≥7 points (OR 13.91) were significantly associated with death at 3 months. In the propensity score analysis, a significant association was found between a high OHAT score (≥7 points) and death at 3 months (P = 0.019). CONCLUSION: Our results indicated that oral health assessed using the OHAT score may be a potential independent prognostic factor in patients with empyema. Similar to the RAPID score, the OHAT score may become an important indicator for the treatment of empyema.2023年, PloS one, 18(3) (3), e0282191, 英語, 国際誌研究論文（学術雑誌）
- 2022年11月, Annals of surgical oncology, 英語, 国際誌研究論文（学術雑誌）
- (公社)日本顎顔面インプラント学会, 2022年11月, Japanese Journal of Maxillo Facial Implants, 21(3) (3), 237 - 237, 日本語当科における口腔癌患者の広範囲顎骨支持型装置の成功率に関する後ろ向き観察研究
- 2022年11月, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 34(6) (6), 734 - 739研究論文（学術雑誌）
- The association between the pretreatment body mass index (BMI) and oral squamous cell carcinoma (SCC) outcomes is controversial. We aimed to examine the association between BMI and cause-specific mortality due to cancer of the oral cavity and patterns of failure that correlate with increased mortality. We enrolled 2,023 East Asian patients in this multicenter cohort study. We used the cumulative incidence competing risks method and the Fine-Gray model to analyze factors associated with cause-specific mortality, local recurrence, regional metastasis, and distant metastasis as first events. The median follow-up period was 62 mo. The 5-year cause-specific mortality for patients with underweight was 25.7%, which was significantly higher than that for patients with normal weight (12.7%, P < 0.0001). The multivariate model revealed that underweight was an independent risk factor for cause-specific mortality and regional metastasis (P < 0.05). Moreover, patients with underweight displayed a 51% and 55% increased risk of cause-specific mortality and regional metastasis, respectively, compared with their normal weight counterparts. Local recurrence was not associated with the BMI categories; however, the incidence of distant metastasis inversely decreased with BMI value. In summary, being underweight at diagnosis should be considered a high-risk mortality factor for oral SCC.2022年10月, Nutrition and cancer, 1 - 12, 英語, 国際誌研究論文（学術雑誌）
- Springer Science and Business Media LLC, 2022年09月, Annals of Surgical Oncology研究論文（学術雑誌）
- Lower third molar extraction is the most common surgical treatment among routine dental and oral surgical procedures. while the surgical procedures for lower third molar extraction are well established, the difficulty of tooth extraction and the frequency of postoperative complications differ depending on the patient's background. To establish a management protocol for the lower third molars, the prevalence of and risk factors for postoperative complications after lower third molar extraction were investigated in a large number of Japanese patients in a multicenter prospective study. During 6 consecutive months in 2020, 1826 lower third molar extractions were performed at the 20 participating institutions. The medical records of the patients were reviewed, and relevant data were extracted. The prevalence of and risk factors for postoperative complications were analyzed. The prevalence of postoperative complications after lower third molar extraction was 10.0%. Multivariate analysis indicated that age (≤32 vs >32, odds ratio [OR]: 1.428, 95% confidence interval [95% CI]: 1.040-1.962, P < .05), the radiographic anatomical relationship between the tooth roots and mandibular canal (overlapping of the roots and canal vs no close anatomical relationship between the roots and the superior border of the canal, OR: 2.078, 95% CI: 1.333-3.238, P < .01; overlapping of the roots and canal vs roots impinging on the superior border of the canal, OR: 1.599, 95% CI: 1.050-2.435, P < .05), and impaction depth according to the Pell and Gregory classification (position C vs position A, OR: 3.7622, 95% CI: 2.079-6.310, P < .001; position C vs position B, OR: 2.574, 95% CI: 1.574-4.210, P < .001) are significant independent risk factors for postoperative complications after lower third molar extraction. These results suggested that higher age and a deeply impacted tooth might be significant independent risk factors for postoperative complications after lower third molar extraction.2022年08月, Medicine, 101(32) (32), e29989, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVES: The purpose of this multicenter retrospective study was to investigate the demographic characteristics and treatment outcomes of patients with mucosal malignant melanoma (MM) of the oral cavity. MATERIALS AND METHODS: This was a multicenter study involving 8 Japanese universities. The medical records of 69 patients who were diagnosed with primary oral MM between January 2000 and December 2020 were retrospectively analyzed. Overall survival (OS) and prognostic factors for OS were analyzed statistically. RESULTS: There were 40 (58.0%) males and 29 (42.0%) females, and their mean (range) age was 69.8 ± 14.6 (22-96) years old. The most common primary site was the palate (30 patients, 43.5%). Stage IVA was the most common disease stage (36 patients, 52.2%). Radical therapy was performed in 55 patients (79.7%). The 2-year and 5-year OS rates of the 69 patients were 64.6% and 42.5%, respectively. The 2-year and 5-year OS rates of the stage III patients were 85.9% and 72.5%, respectively, and those of the stage IVA patients were 56.3% and 26.0%, respectively. The 1-year OS rate of the stage IVB/IVC patients was 26.7%. The 2-year and 5-year OS rates of the radical therapy group were 74.1% and 50.5%, respectively, whereas the 2-year OS rate of the non-radical therapy group was 26.0%. An advanced T classification was the only identified prognostic factor for OS (hazard ratio: 6.312, 95% confidence interval: 1.133-38.522, p < 0.05). CONCLUSIONS: Early detection and radical treatment are essential for improving the prognosis of oral MM patients. CLINICAL RELEVANCE: Early detection and adequate radical therapy leads to the better prognosis of oral MM patients.2022年08月, Clinical oral investigations, 26(10) (10), 6187 - 6193, 英語, 国際誌研究論文（学術雑誌）
- The prognosis of oral cancer that has metastasized to the contralateral cervical lymph nodes is poor, although the appropriate treatment method has not been established because of its rarity. A multicenter retrospective study on the treatment and prognosis of pN2c oral cancer patients was conducted. We investigated the treatment and prognosis of 62 pN2c patients out of 388 pN+ patients with oral squamous cell carcinomas. Statistical analysis was performed on the various factors with overall survival (OS) and disease specific survival (DSS). In multivariate cox regression analysis, advanced T stage was significantly correlated with poor OS (p = 0.011) and DSS (p = 0.023) of patients with pN2c neck. In pN2c patients, OS, DSS, and neck control was not different between those undergoing ipsilateral neck dissection initially and those undergoing bilateral neck dissection. Thus, contralateral elective neck dissection is not recommended. The most important risk factor for prognosis in pN2c oral cancer patients is advanced T stage. No evidence was found to recommend contralateral elective neck dissection in clinically N1/2b patients. Therefore, the indication for contralateral elective neck dissection in N1/2b patients should be carefully determined in consideration of individual conditions.2022年07月, International journal of environmental research and public health, 19(15) (15), 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: Scarring and pain are postoperative complications in patients after head and neck cancer treatment; however, there is no effective treatment. These complications are affected by local blood flow disorders, and it is well known that the transcutaneous application of carbon dioxide (CO2) improves local blood flow. Previously, we have shown that the transcutaneous application of carbon dioxide causes absorption of CO2 and increase the oxygen (O2) pressure in the treated tissue; it is expected that the application of CO2 may reduce scarring and pain caused by cancer treatment. We newly introduced the CO2 paste as a new CO2 application method, which does not need to use CO2 gas directly. In this study, we aimed to apply of CO2 paste to healthy people and to investigate its usefulness, safety and feasibility by analysing the increase in blood flow and frequency of adverse events. METHODS: We applied carbon dioxide paste to skin over the sternocleidomastoid and gastrocnemius muscles of eight healthy volunteers. The changes in blood flow before and after the CO2 paste application using dynamic MRI, and changes in the vital signs were evaluated. RESULTS: In the neck area and middle layer of the lower leg, the signal intensity (SI) significantly increased 60 seconds after application. In the surface layer of the lower leg, the SI was significantly increased 60 and 300 seconds after paste application. Although mild heat was noted after the paste application, no obvious adverse events occurred. CONCLUSION: We demonstrated the increase in SI by dynamic MRI at the site of the carbon dioxide paste application, which indicates the paste application is effective in improving the blood flow.2022年07月, Medicine, 101(29) (29), e29511, 英語, 国際誌研究論文（学術雑誌）
- (NPO)日本口腔科学会, 2022年07月, 日本口腔科学会雑誌, 71(2) (2), 137 - 137, 日本語放射線性顎骨壊死患者を対象とした予後とリスク因子に関する後ろ向き観察研究
- (NPO)日本口腔科学会, 2022年07月, 日本口腔科学会雑誌, 71(2) (2), 91 - 91, 日本語緩和照射に関する臨床的検討
- (NPO)日本口腔科学会, 2022年07月, 日本口腔科学会雑誌, 71(2) (2), 110 - 110, 日本語局所的炭酸ガス投与による口腔扁平上皮癌の腫瘍免疫抑制に対する改善効果
- Mechanical stress induces a variety of biochemical and morphological reactions in bone cell biology. This study aimed to investigate appropriate pressures of osteogenesis on the biological responses of 3-dimensional cultured human mandibular fracture haematoma-derived cells by compressive loading. Six patients with mandibular fractures who underwent open reduction and internal fixation were included in the study. During the operation, fracture haematomas that formed fibrin clots were manually removed before irrigation. First, pressures were applied to human mandibular fracture haematoma-derived cell-seeded collagen sponges. The sponges were subjected to mechanical compression using loading equipment applied at no compression, 0.5, or 1 mm. Compressive loading was applied to the samples prior to compression for 0, 6, 12, or 24 hours. Collagen sponge samples were collected for quantification of mRNA using several parameters including alkaline phosphatase (ALP), osteopontin (OPN), osterix (OSX), runt-related gene 2 (RUNX2), protein level, and immunocytochemistry (anti-sclerostin). Among these the 0.5 mm compression group compared with the control and 1.0 mm compression groups upregulated mRNA expression of OPN and OSX after 24 hours. Additionally, compared with the control group, a significantly higher OSX gene expression was observed in both the 0.5 mm and 1.0 mm groups after 6, 12, and 24 hours of compression (p < 0.05). However, no significant differences were observed regarding ALP and RUNX2 expression. These results indicated increased stimulation of osteogenesis of the mandibular fracture-line gap in the 0.5 mm compression group compared with the control and 1.0 mm compression groups.2022年06月, The British journal of oral & maxillofacial surgery, 60(9) (9), 1216 - 1223, 英語, 国際誌研究論文（学術雑誌）
- 2022年06月, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 19(11) (11), 英語研究論文（学術雑誌）
- OBJECTIVE: The blowing time ratio, which is the ratio of the blowing time when the nostrils are open and closed, is significantly correlated with velopharyngeal pressure, not only during speech but also during swallowing. This study aimed to further evaluate the usefulness of the blowing time ratio as a screening tool to evaluate the swallowing pressure of patients treated for oral and oropharyngeal cancers using high-resolution manometery (HRM). METHODS: Ten patients treated for oral or oropharyngeal cancer were recruited for this study. Swallowing pressures at the velopharynx, oropharynx, and upper esophageal sphincter (UES) were measured using HRM. Their correlations with the blowing time ratio were analyzed. RESULTS: The blowing time ratio was significantly correlated with the swallowing pressures of the oropharynx (CC = 0.815, p = 0.004) and the velopharynx (CC = 0.657, p = 0.039), but not of the UES. CONCLUSIONS: The present results further support our previous finding that the blowing time ratio is a useful screening tool to evaluate velopharyngeal and oropharyngeal swallowing pressures in patients treated for oral and oropharyngeal cancer.2022年06月, Auris, nasus, larynx, 49(3) (3), 477 - 483, 英語, 国際誌研究論文（学術雑誌）
- A standard treatment for osteoradionecrosis (ORN) has not yet been established because of the diversity. Therefore, identifying the risk factors for a poor prognosis is essential. This study retrospectively investigated the factors associated with the prognosis of ORN in 68 patients. Relevant clinical data of all patients were obtained. Of the patients, 16 who underwent extensive surgery underwent histopathological analysis. The necrotic changes of the anterior and posterior margins in the cortical and cancellous bones were investigated. Multivariate analyses showed statistically significant associations between poor prognosis in patients with ORN and high radiation dose (hazard ratio [HR] 1.15), orocutaneous fistula (HR 2.93), and absence of sequestration (HR 2.49). Histopathological analysis showed a viable anterior margin of the middle portion of the cortical bone for all recovered cases; in contrast, most cases (75%) with a poor prognosis showed necrotic changes. The anterior margin of the cancellous bone was viable and resilient to high irradiation, regardless of the prognosis. These results suggest that patients with orocutaneous fistula should receive early surgical intervention, even if the affected area is limited or asymptomatic. In extensive surgery, a sufficient safety margin of necrotic bone, particularly in the anterior region, is required to improve the prognosis.2022年05月, International journal of environmental research and public health, 19(11) (11), 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Extraction of mandibular third molars is one of the most commonly performed oral surgical procedures, and nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management. Oral NSAIDs are associated with adverse events such as gastrointestinal disorders, renal and hepatic dysfunction, and platelet dysfunction. Topical analgesics have been proposed as alternatives to oral and injectable medications to safely improve postoperative pain relief. We will conduct a single-center, placebo-controlled, double-blind, randomized crossover trial to assess the pain-relieving effect of an ibuprofen-containing gargle in patients undergoing extraction of mandibular third molars when compared with a placebo gargle. OBJECTIVE: This will be the first clinical study to compare the efficacy of an ibuprofen gargle with that of a placebo for relieving postoperative pain in addition to loxoprofen after mandibular third molar extraction. METHODS: This study will be performed at Kobe University Hospital. Participants (N=40) will be randomized equally to 1 of 2 groups. The ibuprofen-placebo group will receive an ibuprofen gargle on postoperative day (POD) 1 and a placebo gargle on POD 2. The placebo-ibuprofen group will receive a placebo gargle on POD 1 and an ibuprofen gargle on POD 2. Both groups will receive ibuprofen gargles on PODs 3-5 at least once daily. The primary objective is to estimate the within-subject difference on a visual analog scale (VAS) before and 5 minutes after using the ibuprofen or placebo gargle on PODs 1 and 2. The secondary objectives are to estimate the within-subject differences in ΔVAS before and 15 minutes after using the ibuprofen or placebo gargle on PODs 1 and 2, ΔVAS before and 5 or 15 minutes after using the ibuprofen gargle on PODs 3-5, overall efficacy (self-completion, 5 scales) on PODs 1-5, daily frequency of use (ibuprofen or placebo gargle and analgesics) on PODs 1-7, and the occurrence of adverse events. RESULTS: The Certified Review Board of Kobe University approved the study. The intervention was implemented in May 2021. For the primary analysis, we will calculate the mean and SD of ΔVAS5 on PODs 1 and 2 and the within-study difference in ΔVAS5. The treatment effect will be estimated by dividing the mean ΔVAS5 in the within-subject difference by 2 and calculating the P value using an unpaired t test. For the secondary analysis, we will calculate the mean and SD of ΔVAS15 on PODs 1 and 2 and the within-study difference in ΔVAS15. The treatment effect will be estimated as in the primary analysis. CONCLUSIONS: This trial will provide exploratory evidence of the efficacy and safety of an ibuprofen gargle for pain reduction after mandibular third molar extraction. TRIAL REGISTRATION: Japan Registry of Clinical Trials jRCTs051210022; https://tinyurl.com/39ej23zu. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/35533.2022年05月, JMIR research protocols, 11(5) (5), e35533, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本頭頸部癌学会, 2022年05月, 頭頸部癌, 48(2) (2), 216 - 216, 日本語多施設後ろ向き試験による舌癌における手術断端近接症例の検討 JOOG study(RA2101)
- BACKGROUND: Surgical site infection is a common postoperative complication of colorectal cancer surgery, and surgical site infection increases medical costs, prolongs hospitalization, and worsens long-term prognosis. Perioperative oral care has been reported to be effective in preventing postoperative pneumonia, although there are only a few reports on its effectiveness in preventing surgical site infection. This study aimed to determine the role of perioperative oral care in surgical site infection prevention after colorectal cancer surgery. METHODS: In this study, 1,926 patients with colorectal cancer from 8 institutions were enrolled; 808 patients (oral care group) received perioperative oral care at the hospital's dental clinic, and 1,118 (control group) did not receive perioperative oral care. The data were matched by propensity score to reduce bias. Ultimately, a total of 1,480 patients were included in the analysis. RESULTS: The incidence of surgical site infection was significantly lower in the oral care group than in the control group (8.4% vs 15.7%, P < .001). Multivariate logistic regression analysis revealed 4 independent risk factors for surgical site infection: low albumin level, rectal cancer, blood loss, and lack of perioperative oral care. Lack of perioperative oral care had an odds ratio of 2.100 (95% confidence interval 1.510-2.930, P < .001). CONCLUSION: These results suggest that perioperative oral care can reduce the incidence of surgical site infection after colorectal cancer resection. Perioperative oral care may have an important role in the future perioperative management of colorectal cancer as a safe and effective method of surgical site infection prevention, although further validation in prospective studies is needed.2022年04月, Surgery, 172(2) (2), 530 - 536, 英語, 国際誌研究論文（学術雑誌）
- 2022年04月, Journal of Dental Sciences, 17(2) (2), 1024 - 1029研究論文（学術雑誌）
- OBJECTIVES: This study aimed to retrospectively investigate the success and survival rates of dental implants used for dentomaxillary prostheses at our hospital and the risk factors associated with large bone defects. MATERIALS AND METHODS: A total of 138 external joint system implants used for dentomaxillary prostheses in 40 patients with large bone defects were included in this study. The alveolar bone at the site of implant insertion was evaluated using panoramic radiography and computed tomography. Various risk factors (demographic characteristics, dental status, and operative factors such as the employment of alveolar bone augmentation, the site, the length, and diameter of implants) for implant failure and complete implant loss were investigated using univariate and multivariate analyses. The associations between the variables and the success and survival rates of dental implants were analyzed using the multivariate Cox proportional hazard models. RESULTS: The 10-year overall success and survival rates were 81.3% and 88.4% in this study. Multivariable analysis showed that the male sex (HR 6.22), shorter implants (≤ 8.5 mm) (HR 5.21), and bone augmentation (HR 2.58) were independent predictors of success rate. Bone augmentation (HR 5.14) and narrow implants (≤ 3.3 mm) (HR 3.86) were independent predictors of the survival rate. CONCLUSION: Male sex, shorter or narrow implants, and bone augmentation were independent risk factors for dental implants used in dentomaxillary prostheses in patients with large bone defects. CLINICAL RELEVANCE: Clinicians should consider these risk factors and pay close attention to the management of these patients.2022年03月, Clinical oral investigations, 26(3) (3), 2743 - 2750, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: The purpose of this study was to investigate the risk factors associated with post-extraction persistent bleeding in patients on warfarin or direct-acting oral anticoagulants (DOACs) and the ability of risk scores to predict post-extraction bleeding. METHODS: Three hundred ninety-one patients taking warfarin or DOACs underwent tooth extractions. Various risk factors for post-extraction bleeding, including number of tooth extraction, with antiplatelet therapy, and risk scores, were investigated by univariate and multivariate analyses. A post-extraction bleeding was classified into grades 1-3. RESULTS: The incidence of post-extraction bleeding was 26.8% (77 out of 287 patients; grade 1: 63, grade 2:14) in patients taking warfarin, and 26.0% (27 out of 104 patients; grade 1: 20, grade 2:7) in patients taking warfarin DOACs. Multivariate analyses showed that multiple teeth extractions and HAS-BLED scores (above 3 points) in patients taking warfarin, and only multiple teeth extractions in patients taking DOAC, were significantly associated with post-extraction bleeding, respectively. CONCLUSION: Most of the post-extraction bleedings were grade 1, which can be stopped by eligibly pressing gauze by surgeons. If patients taking anticoagulants are scheduled to undergo multiple teeth extractions or their HAS-BLED score are above 3 points (if warfarin), we recommend informing patients risk of post-extraction bleeding before operation, taking carefully hemostasis, and instructing patients to bite down accurately on the gauze for longer than usual.2022年01月, Oral and maxillofacial surgery, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: This is a randomised, multi-centre, open-label, phase II study to evaluate the efficacy of betamethasone valerate ointment on radiation-induced oral mucositis in patients with head and neck cancer undergoing concomitant radiotherapy with cisplatin or cetuximab. METHODS AND ANALYSIS: The trial will take place at seven hospitals in Japan. Patients will be randomised (1:1) into betamethasone and control groups after the occurrence of grade 1 oral mucositis. In the betamethasone group, patients will use betamethasone valerate ointment five times a day, in addition to usual oral hygiene guidance. The primary endpoint is the incidence and onset time of grade 3 oral mucositis. The secondary endpoints are the incidence and onset time of grade 2 oral mucositis, incidence and onset time of oral candidiasis, completion of radiation therapy and adverse events. Target accrual is 102 patients with a two-sided type I error rate of 5% and 80% power to detect an 80% risk reduction in the incidence of grade 3 oral mucositis. ETHICS AND DISSEMINATION: This study was approved by the Clinical Research Review Board of Nagasaki University (No. CRB20-009). All participants will be required to provide written informed consent. Findings will be disseminated through scientific and professional conferences and peer-reviewed journal publication. The datasets generated during the study will be available from the corresponding author on reasonable request. TRIAL REGISTRATION NUMBER: jRCTs071200013.2022年01月, BMJ open, 12(1) (1), e056781, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本口腔腫瘍学会, 2021年12月, 日本口腔腫瘍学会誌, 33(4) (4), 159 - 163, 日本語
- (一社)日本口腔腫瘍学会, 2021年12月, 日本口腔腫瘍学会誌, 33(4) (4), 159 - 163, 日本語
- (公社)日本顎顔面インプラント学会, 2021年11月, Japanese Journal of Maxillo Facial Implants, 20(3) (3), 189 - 189, 日本語口腔癌術後の再建組織より採取した分層植皮により顎堤形成術を施行した1例
- (公社)日本顎顔面インプラント学会, 2021年11月, Japanese Journal of Maxillo Facial Implants, 20(3) (3), 227 - 227, 日本語放射線下顎骨壊死に対する腓骨皮弁再建後にインプラントによる咬合回復を行った1例
- INTRODUCTION: Delayed wound healing after surgery lowers the long-term quality of a patient's life and leads to discomfort and pain. However, treatments for wound healing are often difficult and have not yet been fully established. In this study, we investigated the effect of a special paste that can be administered transdermally and holds a non-gaseous carbon dioxide (CO2) source in its carrier, which can be applied to the head and neck region for wound healing in a rat skin defect model. METHODS: Forty-eight Sprague Dawley rats were randomized into control and CO2 groups. We punched a 6.2-mm wound on the back of each rat. The control rats were left untreated, whereas rats in the CO2 group were treated with the CO2 paste every day after surgery. We evaluated wound healing 3, 7, 14, and 21 days after wounding by analyzing the diameter of the wound, gene expression of inflammatory markers vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β, hypoxia-inducible factor (HIF)-1α, interleukin (IL)-1β, and IL-6 using quantitative real-time polymerase chain reaction, hematoxylin and eosin, and immunohistochemical staining patterns. RESULTS: Rats in the CO2 group showed accelerated wound healing compared to those in the control group. Furthermore, VEGF and TGF-β were overexpressed, whereas HIF-1α, IL-1β, and IL-6 were downregulated in the rats treated with CO2. Immunohistochemical analysis also revealed similar patterns of expression. CONCLUSION: Taken together, the CO2 paste promoted wound healing by regulating the hypoxic environment, reducing inflammation, and accelerating angiogenesis.2021年11月, Cureus, 13(11) (11), e19518, 英語, 国際誌研究論文（学術雑誌）
- 2021年10月, Journal of Dental Sciences, 16(4) (4), 1241 - 1246研究論文（学術雑誌）
- Schwannomas commonly occur in the head and neck region as acoustic neuromas. Facial nerve schwannomas are rare and usually occur in the temporal region. A 57-year-old woman presented with a mass at the right mandibular margin. Magnetic resonance imaging revealed a schwannoma located immediately caudal to the mental foramen. We were initially uncertain whether it arose from the trigeminal nerve or the facial nerve. Excision was performed under general anesthesia. The mass was encapsulated and easily detached from the surrounding tissue. The nerve of origin was identified proximal to the tumor. A facial nerve origin was confirmed as the muscles supplied by the marginal mandibular branch of the facial nerve moved on nerve stimulation. Nerve fibers were not found distal to the tumor, possibly because they had been cut during excision. We believe that this is the first report of a schwannoma arising from the peripheral facial nerve.2021年07月, Journal of surgical case reports, 2021(7) (7), rjab299, 英語, 国際誌
- Most head and neck lymphoepithelial carcinomas (LECs) arise in the nasopharynx and harbor Epstein-Barr virus (EBV). LEC is also a rare subtype of the oral squamous cell carcinoma (SCC). Morphologically, LEC is defined as resembling non-keratinizing nasopharyngeal carcinoma, undifferentiated subtype. The histological features and pathogenesis of oral LEC are not established. We describe a case of tongue LEC with histopathological diagnostic difficulties. A 72-year-old Japanese female presented with a whitish change on her left-side tongue. The diagnosis was atypical epithelium; neoplastic change could not be ruled out by a biopsy. Although the lesion was monitored at our hospital per her request, invasive carcinoma was detected 11 months later. Microscopically, conventional SCC was observed with the characteristic features as LEC confined to the deep part of the lesion. We briefly discuss this unusual histological finding and make a novel proposal for distinguishing oral LEC from LECs in other regions based on these histological findings.2021年06月, Diagnostics (Basel, Switzerland), 11(6) (6), 英語, 国際誌
- 2021年06月, DIAGNOSTICS, 11(6) (6), 英語研究論文（学術雑誌）
- Pre-existing inflammation, corticosteroid therapy, periapical periodontitis, longer duration of denosumab therapy, and female sex were significantly associated with an increased risk of denosumab-related osteonecrosis of the jaw after tooth extraction in patients with cancer on oncologic doses of denosumab. A short drug holiday did not protect against this complication. INTRODUCTION: This study retrospectively investigated the relationship between various risk factors, including brief discontinuation of denosumab, and development of denosumab-related osteonecrosis of the jaw (DRONJ) after tooth extraction in patients with cancer who were receiving oncologic doses of this agent. METHODS: Data were collected on demographic characteristics, duration of denosumab therapy, whether or not denosumab was discontinued before tooth extraction (drug holiday), duration of discontinuation, presence of pre-existing inflammation, and whether or not additional surgical procedures were performed. Risk factors for DRONJ after tooth extraction were evaluated by univariate and multivariate analyses. RESULTS: A total of 136 dental extractions were performed in 72 patients (31 men, 41 women) with cancer who were receiving oncologic doses of denosumab. Post-extraction DRONJ was diagnosed in 39 teeth (28.7%) in 25 patients. Tooth extraction was significantly associated with development of DRONJ only in patients with pre-existing inflammation (odds ratio [OR] 243.77), those on corticosteroid therapy (OR 73.50), those with periapical periodontitis (OR 14.13), those who had been taking oncologic doses of denosumab for a longer period (OR 4.69), and in women (OR 1.04). There was no significant difference in the occurrence of DRONJ between patients who had a drug holiday before tooth extraction and those who did not. CONCLUSIONS: These findings suggest that inflamed teeth should be extracted immediately in patients with cancer who are receiving oncologic doses of denosumab. Drug holidays have no significant impact on the risk of DRONJ.2021年05月, Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本口腔ケア学会, 2021年04月, 日本口腔ケア学会雑誌, 15(3) (3), 145 - 145, 日本語口腔・中咽頭癌放射線治療326例における重症口腔粘膜炎および口腔カンジダ症発症に関連する因子
- PURPOSE: This study aimed to evaluate the occurrence and treatment outcome of late complications after free fibula osteocutaneous flap reconstruction for mandibular osteoradionecrosis (ORN). METHODS: We enrolled 15 consecutive patients (14 men, one woman; median age 65 years, range 57-80 years) who underwent free fibula reconstruction for advanced mandibular ORN during 2013-2017 with two or more years of follow-up. Late complications included infection, plate exposure, and recurrence at the resection margin. The effect of perioperative antibiotic administration on late complications was also assessed. RESULTS: Late complications occurred in 33.3% (5/15) of patients, including two infections (local and distant), two plate exposures, and two recurrences (plate exposure and recurrence occurred in one patient). Perioperative antibiotic administration duration did not significantly affect the occurrence of postoperative late complications. All late complications were treated without problems. CONCLUSIONS: Late complications after ORN reconstructive surgery are not uncommon, but can be treated properly.2021年03月, Cureus, 13(3) (3), e13833, 英語, 国際誌研究論文（学術雑誌）
- 2021年03月, CUREUS JOURNAL OF MEDICAL SCIENCE, 13(3) (3), 英語研究論文（学術雑誌）
- PURPOSE: In maxillary wisdom tooth extraction, the necessity of CT is unknown. The purpose of this study was to investigate whether CT adding to orthopantomography is useful for predicting oroantral perforation during maxillary third molar extraction. METHODS: Various risk factors for oroantral perforation during maxillary third molar extraction were investigated by univariate and multivariate analyses. We analyzed those of all patients and the patients who underwent CT, respectively. The proximity of the roots to the maxillary sinus floor (root-sinus [RS] classification) and Archer classification were assessed using panoramic radiography. The number of roots and vertical relationship were assessed using CT. RESULTS: A total of 604 out of 3299 patients underwent CT adding to orthopantomography. In all cases, multivariate analyses except for CT findings showed that the RS classification type III/IV and the Archer classification Type B/C/D in panoramic findings were significantly correlated with oroantral perforation as radiological findings. In cases for which CT was performed, multivariate analyses showed that one root (OR 12.87) and the vertical relationship Type D (OR 5.63) in CT findings, besides the RS classification type III/IV (OR 4.47) in panoramic findings, were significantly related to oroantral perforation. CONCLUSION: The RS classification and the Archer classification in panoramic findings can predict the risk of oroantral perforation. The usefulness of CT adding to orthopantomography is limited. However, when the relationship between the upper wisdom tooth and maxillary sinus floor (RS classification) is unclear, to check whether the number of roots is one and the apex of one root is projecting into the maxillary sinus in CT findings, is useful for the prediction.2021年03月, Oral and maxillofacial surgery, 25(1) (1), 7 - 17, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: Radiotherapy (RT) carries a substantial risk for the development of osteoradionecrosis (ORN) of the jaw. This study was performed to investigate the relationship between dental extractions after RT and the development of ORN. MATERIAL AND METHODS: Thirty-two patients with head and neck cancer who underwent tooth extraction after RT were investigated for correlations between the development of ORN and various factors. RESULTS: Postextraction ORN was diagnosed in 12 (12.1%) teeth of 9 patients. The RT dose against the site of tooth extraction was 62.0 and 37.4 Gy in the ORN and Non-ORN groups, respectively (p < .001). The duration from RT to tooth extraction was 41.2 and 28.2 months in the ORN and Non-ORN groups, respectively (p = .025). Tooth extraction was significantly associated with ORN in patients with a high RT dose against the site (odds ratio = 1.231) and a longer duration of time from RT (odds ratio = 1.084). CONCLUSIONS: Extraction of non-restorable teeth and those with a poor prognosis should not necessarily be postponed even when patients are undergoing RT. However, clinicians should pay special attention to postoperative management after tooth extraction in patients with a high RT dose and longer time from RT.2021年03月, Oral diseases, 28(4) (4), 1181 - 1187, 英語, 国際誌研究論文（学術雑誌）
- 2021年02月, JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, 21(3) (3), 856 - 864, 英語研究論文（学術雑誌）
- BACKGROUND: This prospective study investigated the change of swallowing ability using the Swallowing Ability Scale System (SASS) and swallowing-related quality of life (QOL) by Performance Status Scale for Head and Neck Cancer patients (PSS-H&N). This study also investigated the risk factors for postoperative dysphagia in patients who received reconstructive surgery for oral cancer. SUBJECTS AND METHODS: This study included 64 patients (33 men and 31 women) who underwent radical surgery with neck dissection and reconstructive surgery for oral cancers between July 2014 and February 2018. We evaluated risk factors for poor swallowing ability after treatment, including demographic factors, preoperative factors and perioperative factors, with univariate and multivariate analyses. The change of swallowing ability by the SASS and swallowing-related QOL by PSS-H&N were evaluated prospectively prior to the initiation of surgery within 1 week and at 1 and 3 months after treatment. RESULTS: Advanced T stage (T3, 4) (odds ratio (OR) = 79.71), bilateral neck dissection (OR = 20.66) and the resection of unilateral or bilateral suprahyoid muscles (OR = 17.00) were associated with poor swallowing ability after treatment. The scores for time for food intake and Eating in Public were associated with decrease of QOL in the poor group. CONCLUSIONS: We propose that clinicians consider the risk factors identified in this study and pay close attention to the management of oral cancer patients with reconstructive surgery.2021年01月, Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 50(1) (1), 4 - 4, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: To evaluate factors associated with osteoradionecrosis of the jaw (ORNJ) in patients with head and neck squamous cell carcinoma (HNSCC), focusing on jaw-related dose-volume histogram (DVH) parameters. METHODS: We retrospectively reviewed the medical records of 616 patients with HNSCC treated with curative-intent or postoperative radiation therapy (RT) during 2008-2018. Patient-related (age, sex, history of smoking or alcohol use, diabetes mellitus, performance status, pre-RT dental evaluation, pre- or post-RT tooth extraction), tumor-related (primary tumor site, T-stage, nodal status), and treatment-related (pre-RT surgery, pre-RT mandible surgery, induction or concurrent chemotherapy, RT technique) variables and DVH parameters (relative volumes of the jaw exposed to doses of 10 Gy-70 Gy [V10-70]) were investigated and compared between patients with and without ORNJ. The Mann-Whitney U test was used to compare RT dose parameters. Univariate and multivariate Cox regression analyses were used to assess factors associated with ORNJ development. Kaplan-Meier analyses were performed for cumulative ORNJ incidence estimation. RESULTS: Forty-six patients (7.5%) developed ORNJ. The median follow-up duration was 40 (range 3-145) months. The median time to ORNJ development was 27 (range 2-127) months. DVH analysis revealed that V30-V70 values were significantly higher in patients with than in those without ORNJ. In univariate analyses, primary tumor site, pre-RT mandible surgery, post-RT tooth extraction, and V60 > 14% were identified as important factors. In multivariate analyses, V60 > 14% (p = 0.0065) and primary tumor site (p = 0.0059) remained significant. The 3-year cumulative ORNJ incidence rates were 2.5% and 8.6% in patients with V60 ≤ 14% and > 14%, respectively (p < 0.0001), and 9.3% and 1.4% in patients with oropharyngeal or oral cancer and other cancers, respectively (p < 0.0001). CONCLUSIONS: V60 > 14% and oropharyngeal or oral cancer were found to be independent risk factors for ORNJ. These findings might be useful to minimize ORNJ incidence in HNSCC treated with curative RT.2021年01月, Radiation oncology (London, England), 16(1) (1), 1 - 1, 英語, 国際誌研究論文（学術雑誌）
- Advanced mandibular osteoradionecrosis (ORN) sometimes requires extended resection (e.g., hemimandibulectomy). Bacterial infection contributes to ORN pathogenesis. To control infection and determine the extent of debridement required, an understanding of bacterial spread within sites of mandibular ORN is important. The current study used a histopathological approach to assess bacterial colonization in the mandibular condyle and elucidate possible paths of bacterial spread towards the mandibular condyle. Four hemimandibulectomy specimens were selected. Areas of bone destruction were macroscopically assessed and confirmed using hematoxylin and eosin staining. Bacterial presence within mandibular condyle was confirmed with Gram staining. Bone exposure was observed in the molar area in all specimens. Macroscopic bone destruction was apparent especially near the medial side of the cortical wall. Gram staining revealed bacterial colonization of the mandibular condyle in three of the four specimens. In conclusion, bacteria tended to spread posteriorly and through the medial side of the mandibular cortical wall. In patients with advanced ORN, the potential for bacterial colonization of the mandibular condyle should be considered during treatment.2021年, International journal of dentistry, 2021, 9998397 - 9998397, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: In recent years, the tumour immunosuppressive mechanism has attracted attention as a cause of tumour chemoresistance. Although chemoresistance and immunosuppression of tumours have been reported to be associated with a hypoxic environment, effective treatments to improve hypoxia in tumours have not yet been established. We have previously applied carbon dioxide (CO2) to squamous cell carcinoma and have shown that improvement in local oxygenation has an antitumour effect. However, the effects of local CO2 administration on tumour immunosuppression, chemoresistance, and combination with chemotherapy are unknown. In this study, we investigated the effects of local CO2 administration on squamous cell carcinoma and the effects of combined use with chemotherapy, focusing on the effects on tumour immunosuppressive factors. METHODS: Human oral squamous cell carcinoma (HSC-3) was transplanted subcutaneously into the back of a nude mouse, and CO2 and cisplatin were administered. After administration twice a week for a total of 4 times, tumours were collected and the expression of tumour immunosuppressive factors (PD-L1, PD-L2, and galectin-9) was evaluated using real-time polymerase chain reaction and immunostaining. RESULTS: Compared with the control group, a significant decrease in the mRNA expression of PD-L1 was observed in both, CO2-treated and combination groups. Similarly, the expression of PD-L2 and galectin-9 decreased in the CO2-treated and combination groups. Furthermore, immunostaining also showed a significant decrease in the protein expression of tumour immunosuppressive factors in the CO2-treated and combination groups. CONCLUSION: It was confirmed that the tumour immunosuppressive factors decreased due to local CO2 administration to the mouse model. CO2 administration has the potential to improve the hypoxic environment in tumours, and combined use with chemotherapy may also improve tumour immunosuppression.2021年, BioMed research international, 2021, 5568428 - 5568428, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: Elongated mandibular coronoid process is a rare condition defined as enlargement of the coronoid process. The only useful way to treat the mouth-opening limitation is resection of the elongated coronoid process. Four-dimensional CT (4DCT; three spatial dimensions plus time axis) is a novel imaging technique. Its usefulness of for evaluation of dynamic movements such as joint motion has been reported. Here, we show the potential usefulness of 4DCT evaluation in a patient with elongated mandibular coronoid process. CASE PRESENTATION: A 59-year-old female who suffered from mouth-opening difficulty and pressure during mouth opening was referred to our department. Elongation of the right coronoid process was evident in a panoramic X-ray image. The mandibular movement and temporal muscle motility before and after coronoidectomy in this patient on 4DCT could be evaluated. CONCLUSIONS: 4DCT is useful in the diagnosis and surgical outcome of elongated coronoid process.2020年12月, Oral and maxillofacial surgery, 24(4) (4), 515 - 520, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Various antibiotics and analgesics have been reported to interact with warfarin. Reports that investigate the effects of medication taken for just a few days during tooth extraction on the prothrombin time-international normalized ratio are rare. METHODS: A total of 110 patients receiving long-term stable warfarin therapy underwent tooth extraction without interruption of warfarin treatment. INR values were measured 1 month before the tooth extraction, the day of the extraction, and 1 week after the extraction. We investigated the changes in INR values between the day of extraction and 1 week after extraction, as well as the various risk factors for increases in INR values. RESULTS: Before and after tooth extraction, the number of patients taking cefcapene pivoxil, amoxicillin, and azithromycin was 57, 36, and 8, respectively. Nine patients were administered ampicillin before tooth extraction and received amoxicillin after their tooth extraction. One week after tooth extraction, the INR values increased beyond the therapeutic range in 3 out of 110 patients (2.7%). The INR values before tooth extraction in these three patients were close to 3.0. The INR value increased by more than twice as much in 1 out of 110 patients (0.9%). CONCLUSION: Our results suggest that prophylactic antibiotic administration has little effect on INR values when patients on stable warfarin therapy undergo tooth extraction. Surgeons have to take attention if the patients whose INR values are close to 3.0 before their extraction.2020年11月, BMC oral health, 20(1) (1), 331 - 331, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本外科感染症学会, 2020年10月, 日本外科感染症学会雑誌, 17(5) (5), 329 - 329, 日本語
- (一社)日本外科感染症学会, 2020年10月, 日本外科感染症学会雑誌, 17(5) (5), 329 - 329, 日本語
- (一社)日本医用画像工学会, 2020年09月, 日本医用画像工学会大会予稿集, 39回, 30 - 30, 日本語顎骨骨髄炎発症範囲推定のための頭部CT・切除顎骨CTの位置合わせ自動化
- (一社)日本医用画像工学会, 2020年09月, 日本医用画像工学会大会予稿集, 39回, 173 - 177, 日本語顎骨骨髄炎発症範囲推定のための頭部CT・切除顎骨CTの位置合わせ自動化
- (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14(3) (3), 114 - 114, 日本語膵頭十二指腸切除術における周術期口腔機能管理の術後合併症予防効果
- (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14(3) (3), 123 - 123, 日本語周術期口腔ケアによる胃癌術後合併症予防効果に関する臨床的検討
- (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14(3) (3), 53 - 54, 日本語口腔ケアのエビデンスを検証するためにはどのような研究をすればよいのか アカデミア臨床研究環境のこれまで 臨床研究法施行の背景
- (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14(3) (3), 122 - 122, 日本語大腸癌術後合併症に対する周術期口腔機能管理の予防効果に関する多施設共同研究
- 2020年09月, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 32(5) (5), 356 - 359研究論文（学術雑誌）
- (一社)日本頭頸部癌学会, 2020年07月, 頭頸部癌, 46(2) (2), 183 - 183, 日本語口腔癌cN(+)における根治的頸部郭清範囲の検討
- (NPO)日本口腔科学会, 2020年07月, 日本口腔科学会雑誌, 69(2) (2), 121 - 121, 日本語顎骨壊死を契機として切開排膿を要した咀嚼筋隙膿瘍の検討
- (NPO)日本口腔科学会, 2020年07月, 日本口腔科学会雑誌, 69(2) (2), 153 - 153, 日本語当科で歯科介入を行った高用量骨吸収抑制薬使用患者におけるMRONJ発症とリスク因子についての検討
- Postoperative hemorrhage after tooth extraction is a critical and clinically important issue for clinicians and patients receiving anticoagulants. The purpose of the present study was to investigate the prevalence of and risk factors for postoperative hemorrhage after lower third molar extraction in Japanese patients receiving warfarin therapy. A total of 142 patients who underwent lower third molar extraction between January 2010 and December 2016 were included, and their medical records were retrospectively reviewed. The prevalence of and risk factors for postoperative hemorrhage were investigated. The prevalence of postoperative hemorrhage after lower third molar extraction was significantly higher in patients receiving warfarin than in healthy subjects (21.8% vs 0.7%, P < 0.001). The cutoff value for PT-INR was 2.11 based on a receiver-operating characteristic analysis. A multivariate analysis indicated that an elevated PT-INR value [hazard ratio (HR) 3.798, 95% confidence interval (CI) 1.400-10.467, P < 0.01], preoperative antibiotic administration (HR 4.434, 95% CI 1.591-14.775, P < 0.01), difficulties with intraoperative hemostasis (HR 16.298, 95% CI 2.986-110.677, P < 0.01), and higher serum creatinine levels (HR 7.465, 95% CI 1.616-39.576, P < 0.05) are significant predictors of postoperative hemorrhage after lower third molar extraction. Multivariate correlations were observed between risk factors including an elevated PT-INR value, preoperative antibiotic administration, and higher serum creatinine levels, and postoperative hemorrhage after lower third molar extraction in patients receiving warfarin therapy. Clinicians need to consider these risk factors for postoperative hemorrhage after the lower third molar extraction and monitor PT-INR in patients receiving warfarin therapy.2020年07月, Odontology, 108(3) (3), 462 - 469, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Prognostic biomarkers provide essential information about a patient's overall outcome. However, existing biomarkers are limited in terms of either sample collection, such as requiring tissue specimens, or the process, such as prolonged time for analysis. In view of the need for convenient and non-invasive prognostic biomarkers for oral cancer, we aimed to investigate the prognostic values of neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio in patient survival. We also aimed to explore the associations of these ratios with the clinicopathologic characteristics of Japanese oral squamous cell carcinoma patients. METHODS: This study was a non-randomized retrospective cohort study in a tertiary referral center. We included 433 patients (246 men, 187 women) who underwent radical surgery for oral cancers between January 2001 and December 2013. We evaluated various risk factors for poor prognosis including neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio with univariate and multivariate analyses. The disease-specific survival and overall survival rates of patients were compared among the factors and biomarkers. RESULTS: In multivariable Cox proportional hazards analysis, high neutrophil-to-lymphocyte ratio (hazard ratio 2.87, 95% confidence interval 1.59-5.19, P < 0.001), moderately or poorly differentiated histology (hazard ratio 2.37, 95% confidence interval 1.32-4.25, P < 0.001), and extranodal extension (hazard ratio 1.95, 95% confidence interval 1.13-3.35, P = 0.016) were independent predictors of disease-specific survival. High neutrophil-to-lymphocyte ratio (hazard ratio 2.30, 95% confidence interval 1.42-3.72, P < 0.001), moderately or poorly differentiated (hazard ratio 1.72, 95% confidence interval 1.07-2.76, P = 0.025), and extranodal extension (hazard ratio 1.79, 95% confidence interval 1.13-2.84, P = 0.013) were independent predictors of overall survival. CONCLUSIONS: Neutrophil-to-lymphocyte ratio might be a potential independent prognostic factor in Japanese oral squamous cell carcinoma patients.2020年06月, BMC cancer, 20(1) (1), 568 - 568, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- OBJECTIVES: The present study investigated the clinical significance of the G8 screening tool in elderly oral squamous cell carcinoma (OSCC) patients using a multicenter analysis. MATERIALS AND METHODS: The medical records of 438 primary OSCC patients aged 75 years and older were retrospectively reviewed. To examine the clinical significance of the G8 screening tool in elderly OSCC patients, self-reliance (SR) rates and prognostic factors were statistically analyzed. RESULTS: The mean score of the G8 screening tool was 10.9 ± 2.93. The SR cut-off value of the G8 score was 9.5 in a receiver operating characteristic curve analysis. Five-year overall survival rates were 40.1% in patients with a G8 score < 9.5 and 58.4% in those with a G8 score ≥ 9.5 (p < 0.01). Five-year cancer-specific rates were 34.3% in patients with a G8 score < 9.5 and 55.7% in those with a G8 score ≥ 9.5 (p < 0.01). Five-year SR rates were 40.7% in patients with a G8 score < 9.5 and 55.3% in those with a G8 score ≥ 9.5 (p < 0.05). A multivariate analysis identified an advanced age (≥ 80 vs < 80; HR, 1.437; 95%CI, 1.181-1.843; p < 0.01), poorer ECOG-PS (2-4 vs 0-1; HR, 1.560; 95%CI, 1.14-2.106; p < 0.01), and standard treatment (non-standard therapy vs standard therapy; HR, 0.598; 95%CI, 0.405-0.910; p < 0.05) as significant independent prognostic factors for SR. A lower G8 score was associated with poorer SR (≥ 9.5 vs < 9.5; HR, 0.765; 95%CI, 0.575-1.034; p = 0.081). CONCLUSION: The clinical significance of the G8 score for elderly OSCC patients was demonstrated and its combination with ECOG-PS may be useful for assessing their prognoses.2020年06月, Clinical oral investigations, 24(6) (6), 1953 - 1961, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- PURPOSE: This study retrospectively investigated relationships among risk factors and post-hepatectomy surgical site infection (SSI) and other complications in patients who underwent hepatectomy for hepatocellular carcinoma (HCC). METHODS: We included 334 patients who underwent hepatectomies for liver cancers between January 2011 and December 2015 in this study. We evaluated risk factors for SSI and other post-hepatectomy complication, including demographic factors, preoperative factors, and preoperative intervention including oral management, perioperative factors, and length of hospital stay, with univariate and multivariate analyses. The oral management intervention included self-care instructions, extraction of infected teeth, removal of dental plaques and calculus (scaling), professional mechanical teeth cleaning, removal of tongue coating, and cleaning of dentures. SSI was defined in accordance with the guideline issued by the Centers for Disease Control and Prevention; it included purulent discharge from any incision or organ space within 30 days postoperatively, with or without microbiological evidence. Complications of grade II or greater, according to the Clavien-Dindo classification, were regarded as postoperative complications. RESULTS: We found bacterial infection of ascites (Odds ratio (OR) = 13.72), lack of preoperative oral management intervention (OR = 10.17), and severe liver fibrosis (OR = 2.76) to be associated with SSI and severe liver fibrosis (OR = 2.28), hypoalbuminemia (OR = 2.02), blood transfusion (OR = 1.86), and longer operation time (OR = 1.80) to be associated with postoperative complications. CONCLUSIONS: Preoperative oral management may reduce the risk of SSI in patients with HCC who undergo hepatectomy.2020年05月, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(2) (2), 653 - 659, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2020年05月, Support Care Cancer., 283(3) (3), 1069 - 1075Factors associated with severe oral mucositis and candidiasis in patients undergoing radiotherapy for oral and oropharyngeal carcinomas: a retrospective multicenter study of 326 patients.[査読有り]
- BACKGROUND: No clear consensus has been reached on the indication of supraomohyoid neck dissection (SOHND) for clinically positive lymph-node metastasis. PATIENTS: Consecutive 100 patients with previously untreated oral cancer treated at Kobe University Hospital were included in this study. All patients were clinically staged as anyTN1M0 and underwent radical dissection of the primary site and level I-V neck dissection as the initial treatment. RESULTS: None of the 100 patients had pathological lymph-node metastasis (pLN) to level V. pLN to level IV was observed in two patients with tongue cancer in whom clinical lymph-node metastasis was preoperatively observed at level II. CONCLUSIONS: Level V may be excluded in the neck dissection for patients with N1 oral cancers. Level IV dissection should be considered in the patient with tongue cancer and clinical lymph-node metastasis at level II.2020年03月, International journal of clinical oncology, 25(6) (6), 1067 - 1071, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- Patients develop a number of oral complications during cancer treatments. Oral bacteria are associated with the onset of dental focal infections and the progression of oral mucositis. Dental focal infections are frequently associated with the systemic onset of bacteremia, sepsis, and pneumonia. The degeneration of oral function with these complications may become an obstacle to cancer treatments. Although comprehensive oral management, including oral care, the removal of dental focal infections, and improvements in oral function with dentures, is conducted for cancer patients in Japan, few studies have assessed its efficacy.The aim of the present study was to investigate the incidence of dental/oral complications in cancer patients with perioperative oral managements (POMs) based on a large number of case series with a multicenter retrospective analysis.The medical records of cancer patients with POMs were retrospectively reviewed and the incidence of oral complications and efficacy of oral management were investigated.A total of 2744 cancer patients with POMs (1684 males and 1080 females, mean age 65.9 ± 13.0 years) were included and investigated in the present study. Among these patients, 2097 (76.4%) started POM before the initiation of cancer treatments, with 2130 (77.6%) receiving oral care only and 391 (14.2%) being subjected to invasive treatments, such as tooth extraction. The incidence of dental focal infections during the period of cancer treatments was 8.2%. The most frequent infection was acute periodontitis, including alveolar abscesses (112 patients, 4.1%). The incidence of grade 2 and 3 oral mucositis was 2.8%. Prolonged fever was observed in 113 patients (4.1%), with 7 having dental focal infections (6.2%). These incidence rates were lower than those reported previously.Based on analyses of a large number of patients, the present results support the efficacy of oral management in cancer patients. However, further studies are needed to establish adequate oral management guidelines for cancer patients.2020年03月, Medicine, 99(10) (10), e19129, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Oral health is associated with various diseases, including cancer. Tooth loss is a simple and objective index of oral health. OBJECTIVE: The purpose of this study was to investigate the association between preoperative tooth loss and esophageal cancer prognosis after esophagectomy. METHODS: This study included 191 patients who underwent esophagectomy for esophageal cancer after perioperative dental evaluation and oral care at Kobe University Hospital from April 2011 to March 2016. Patients were divided into two groups: Group A (tooth loss < 7) and Group B (tooth loss ≥ 7). Three-year overall survival (OS) and multivariate analysis were performed, along with subgroup analysis for elderly patients (age ≥ 65 years). RESULTS: The 3-year OS rate was 68.1% in Group A (104 patients) and 49.2% in Group B (87 patients). Group A had significantly higher OS than Group B (p = 0.002), and there were no significant differences in sex and clinical T or N stage between the two groups. However, the mean age of Group A was younger than that of Group B (64.2 vs. 68.5 years; p = 0.0002). Among elderly patients, the 3-year OS rate was 68.2% in Group A (55 patients) and 45.1% in Group B (65 patients) [p = 0.003]. Multivariate analysis that included age demonstrated that tooth loss is an independent prognostic factor (hazard ratio 1.87, 95% confidence interval 1.22-2.87), in addition to clinical T stage and preoperative serum albumin. CONCLUSION: Tooth loss is an independent prognostic factor for esophageal cancer after esophagectomy.2020年03月, Annals of surgical oncology, 27(3) (3), 683 - 690, 英語, 国際誌[査読有り]
- PURPOSE: Postoperative pneumonia is one of the major complications after esophageal cancer surgery. The risk factors associated with postoperative pneumonia are poor general health, smoking, decreased pulmonary function, diabetes mellitus, surgical stress, old age, postoperative aspiration, and oral hygiene. In this study, we examined the effect of perioperative oral care on reducing postoperative pneumonia since the evidence to-date is not clear. METHODS: A multicenter, retrospective investigation of the relationship between perioperative oral care and incidence of postoperative pneumonia in patients undergoing esophageal cancer surgery was conducted. A total of 775 patients who underwent thoracoscopic esophageal resection at 25 hospitals between 2016 and 2017 were enrolled in the study. Various factors were examined for correlation with development of postoperative pneumonia. RESULTS: Multivariate analysis showed that old age, smoking habit, lower hemoglobin, higher creatinine, postoperative dysphagia, and lack of oral care intervention were independent risk factors for pneumonia. Oral care was more effective in preventing pneumonia in hospitals in which the incidence of postoperative pneumonia was lower than 20%, while it was not effective in hospitals in which the incidence was higher than 20%. CONCLUSION: Results of the study suggest that it is recommended to carry out perioperative oral care in esophageal cancer surgery.2020年01月, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 28(9) (9), 4155 - 4162, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 社団法人 日本口腔外科学会, 2020年, 日本口腔外科学会雑誌, 66(5) (5), 219 - 223, 日本語
Papillary squamous cell carcinoma (PSCC) is a rare variant of squamous cell carcinoma with only a few documented cases in the oral cavity. We report the case of a 70-year-old man who presented with papillary squamous cell carcinoma of the mandibular gingiva.
The patient was referred to our department because of a papillary tumor in the right mandibular gingiva. A physical examination revealed an exophytic papillary tumor in the right mandibular gingiva. Biopsy samples for histopathological diagnosis were taken two times. However, the biopsies did not reveal squamous cell carcinoma. Moreover, the pathological diagnosis obtained from intraoperative frozen-section analysis was cancer negative. Therefore, the operation consisted of resection of the tumor including a margin of 5-7 mm. Microscopically, the tumor showed exophytic papillary proliferation with fibrovascular cores and consisted of atypical squamous epithelial cells. The pathological diagnosis was PSCC. Three months later, local recurrence was observed and was resected again. The patient was healthy and remained free from tumors 18 months after the second operation. We report a rare case of PSCC. With small biopsy specimens, the diagnosis of PSCC was challenging.
- Cetuximab, an epidermal growth factor receptor inhibitor (EI), is currently the only targeted molecular therapy used in combination with radiotherapy for head and neck squamous cell carcinoma (HNSCC). Gold nanoparticles (AuNPs) are expected to enhance radiotherapy effects in cancers. To investigate whether AuNPs combined with AG1478, an EI, enhanced irradiation effects on HNSCC cells, we first examined AG1478 adsorption on AuNP surfaces, using surface-enhanced Raman scattering, which indicated an adsorption equilibrium of AG1478 to AuNPs. We then used transmission electron microscopy to find internalization rates of AuNP alone and AuNP+AG1478; we found that intracellular uptake of AuNP alone and AuNP+AG1478 did not significantly differ. We compared cell numbers, proliferation, apoptosis, and migration between control cells and those treated with or without 60 nm AuNP (1.0 nM), AG1478 (0.5 μM), and irradiation (4 Gy). We found that AuNP+AG1478 inhibited proliferation more than AG1478 alone; the combination of irradiation+AuNP+AG1478 significantly reduced total cell numbers compared with the combination of irradiation+AuNP; AuNP+AG1478 increased apoptotic reaction to irradiation; the combinations of AuNP+AG1478 and irradiation+AuNP induced more apoptosis than AG1478+irradiation. Whereas AuNP+AG1478 enhanced cytotoxicity in human HNSCC cells by inhibiting proliferation, irradiation+AuNP enhanced cytotoxicity by inducing apoptosis.2020年, BioMed research international, 2020, 1281645 - 1281645, 英語, 国際誌研究論文（学術雑誌）
- Treatment strategies of medication-related osteonecrosis of the jaw (MRONJ) are controversial. Recently, surgical treatment has been reported as superior to nonsurgical treatment, but the contribution discontinued antiresorptive agent use during MRONJ treatment remains unclear. This study aimed to evaluate the efficacy of drug holidays and treatment strategies in MRONJ cases. Four-hundred and twenty-seven patients with MRONJ treated at nine hospitals from 2009 to 2017 were included in this multicenter retrospective study. Multivariate Cox regression analysis showed that the primary disease (osteoporosis or malignant tumor), diabetes, serum albumin, and treatment method (surgical or nonsurgical) were significantly correlated with the cure rate. The cumulative 1-year cure rates in the surgical and nonsurgical treatment groups were 64.7% and 18.2%, respectively. However, discontinuing antiresorptive agents did not influence the treatment outcome in the cohort overall, or in 230 patients after performing propensity score matching among the discontinuation and continuation groups. When stratifying by treatment method, antiresorptive agent discontinuation significantly increased the cure rate in patients with osteoporosis who underwent nonsurgical treatment. In patients with malignant tumors undergoing nonsurgical therapy, discontinuing the antiresorptive agent was associated with a better treatment outcome, but not with statistical significance. In contrast, drug holidays showed no effect on improving outcomes in patients with both osteoporosis and malignant tumors who underwent surgical therapy. Thus, regardless of the primary disease, discontinuing antiresorptive agents during treatment for MRONJ may not be necessary and may be helpful in some cases. Future prospective trials should examine this question further.2020年01月, Journal of bone and mineral metabolism, 38(1) (1), 126 - 134, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- (一社)日本有病者歯科医療学会, 2019年12月, 有病者歯科医療, 28(6) (6), 471 - 471, 日本語抗凝固薬内服患者における下顎智歯抜去後の後出血発症に関する多施設共同後ろ向き観察研究
- 2019年12月Prevention of postoperative pneumonia by perioperative oral care[査読有り]
- OBJECTIVE: The present study investigated the effect of low-intensity pulsed ultrasound (LIPUS) on long-term osseous healing of the cleavage space between bone fragments after intraoral vertical ramus osteotomy (IVRO). STUDY DESIGN: Patients undergoing IVRO were randomly assigned to the LIPUS group (n = 12) or the control group (n = 9) after surgery. LIPUS treatments were applied daily to the cleavage space between bone fragments for 3 weeks. We observed 3-dimensional quantitative color mapping of the whole mandible created by computed tomography (CT) data at 1 month, 6 months, and 1 year postoperatively. On the basis of CT values, the color grades were classified as D1 to D5 by using the Misch criteria. We then calculated mean CT values and rated each color grade in different selection ranges. RESULTS: The mean CT values of the LIPUS group were significantly higher than those of the control group at 1 month, 6 months and 1 year postoperatively (P < .01). The color grades of the cleavage between bone fragments increased from D5 to D1 over time. CONCLUSIONS: Our results indicated that LIPUS promoted osseous healing after IVRO, thus improving bone density and offering clinical benefits.2019年12月, Oral surgery, oral medicine, oral pathology and oral radiology, 128(6) (6), 581 - 589, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2019年11月, International Journal of Oral & Maxillofacial Surgery, in pressPostoperative adjuvant therapy for patients with locoregionally advanced oral squamous cell carcinoma who are at high risk of recurrence.[査読有り]
- 2019年09月, 日本口腔腫瘍学会誌, 31(3) (3), 117-120[総説]口腔・中咽頭がん患者の放射線性顎骨壊死発症リスク因子について：多施設共同後ろ向き研究の結果より
- BACKGROUND: The purpose of this study was to investigate the effectiveness of dental intervention before and after radiation therapy (RT) for head and neck malignancy on prevention of osteoradionecrosis (ORN) of the jaws. METHODS: This is a single-arm prospective study according to intervention protocol of prophylactic dental extraction before RT and routine follow-up after RT. The primary endpoint was the occurrence of jawbone exposure during the first 2 years after RT. RESULTS: Sixty-seven patients were assessed. Before RT, 144 teeth among 39 patients (58%) were prophylactically extracted. The occurrence of transient jawbone exposure during the first 2 years after RT was 7%. Because those jawbone exposures healed with intervention after RT, no jawbone exposure was found at 2 years after RT. CONCLUSIONS: Dental intervention both before and after RT seemed to be important to prevent ORN development. Further studies in larger cohorts are necessary.2019年09月, Oral and maxillofacial surgery, 23(3) (3), 297 - 305, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND AND OBJECTIVE: Forearm free flaps are used after hemiglossectomy. However, no investigation has been performed on whether oral functions are better preserved when sizes of the resection and reconstruction flap are exact matches, or whether the size of the resection should be changed. We aimed to retrospectively examine whether size differences between the resection and reconstruction flap affect speech and swallowing functions postoperatively, and to determine whether there are more favorable flap size ratios. METHODS: This is a retrospective cohort study of patients undergoing hemiglossectomy using a forearm free flap between 2006 and 2016 at Kobe University Hospital, Japan. The effect of size difference between the resection and reconstruction flap on maintained oral function was assessed. Speech and swallowing functions were assessed, and their correlation with the ratio of the flap size to that of the resected area was determined. With these data, distribution maps of the relationship between the functional level and reconstructed dimension ratio were prepared. The more suitable reconstructed dimension ratio was examined and evaluated. The Fisher exact test, Kruskal-Wallis test, and Scheffe test were used in statistical analyses. RESULTS: Eighty-eight patients underwent hemiglossectomy using a forearm free flap during a 10-year period. Of these cases, 66 patients were included in this study, while 22 were excluded. The ratio of the area of the reconstruction flap to that of the resection site was 0.59-2.79 (median: 1.61). Sixty patients had flaps greater than the resection area, whereas 6 had smaller flaps. Significant differences were found in speech intelligibility and swallowing function when the reconstructed dimension ratio was categorized as follows: ≤1.3, 1.3-1.8, and ≥1.8. CONCLUSION: Our findings suggest that postoperative deterioration of oral functions after hemiglossectomy could be reduced if reconstruction is performed using a forearm free flap with a surface area 1.3 to 1.8 times greater than that of the resection area.2019年07月, J Plast Reconstr Aesthet Surg, 72(7) (7), 1135 - 1141, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: The purpose of this study was to retrospectively describe the characteristics and outcomes of patients with oral squamous cell carcinoma and level IV/V metastasis and to compare patients who underwent no postoperative therapy with those who underwent postoperative radiotherapy (RT) and concomitant chemoradiotherapy (CCRT). METHODS: We evaluated 669 patients. Clinicopathological data, postoperative therapy, and clinical course were investigated. RESULTS: Sixty-one patients (9.1%) developed level IV/V metastasis. The 3-year cumulative overall survival rates of patients with and without level IV/V metastasis were 47.3% and 64.3%, respectively. Tongue tumors, pN2 or N3 classification, and moderate or poor differentiation were significantly associated with the development of level IV/V metastasis. The surgery+RT/CCRT group was associated with better 3-year cumulative disease-specific survival and overall survival rates than the surgery only group. CONCLUSION: Adjuvant therapy (RT alone or CCRT) after surgery is recommended for patients with level IV/V metastasis.2019年07月, Head Neck., 41(7) (7), 2256 - 2263, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- PURPOSE: Evaluation of the inner aspect of the maxillary sinus is important for the success of a sinus lift procedure. The most common surgical complication is perforation of the Schneiderian membrane, which is thought to occur because of the presence of maxillary sinus septa. Therefore, we retrospectively investigated the incidence and morphology of maxillary sinus septa using multiplanar reformatted computed tomographic (CT) images from dentate Japanese patients. METHODS: A total of 276 patients and 552 maxillary sinus segments were evaluated. The maxillary sinus septa were divided into four locations: forefront, anterior, middle, and posterior. The heights of the septa were measured at three sites from the deepest point of the sinus floor: lateral, mid-point, and medial. RESULTS: Sinus septa were identified in 191 of 552 (34.6%) maxillary sinus segments obtained from 111 of 276 (40.2%) patients. One unilateral septum was most commonly detected, and the sinus septa were most often located in the middle of the maxillary sinus. The average height of the identified septa was 8.69 ± 4.68 mm (mean ± standard deviation). CONCLUSION: Multiplanar reformatted CT images can identify maxillary sinus septa in any plane. The height of maxillary sinus septa in the dentate maxillae was higher than detected in previous studies. Appropriate treatment planning using CT images should be considered to prevent surgical complications.2019年06月, Oral and maxillofacial surgery, 23(2) (2), 233 - 237, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Postoperative pneumonia can be a fatal complication that may occur after lung resection in cancer patients. Some reports have shown that the incidence of postoperative pneumonia is decreased after esophageal surgery by perioperative oral care; however, there exist no data to suggest that a lack of perioperative oral care can be a risk factor for postoperative pneumonia after lung resection. To investigate the association between the preventive effect of oral care and postoperative pneumonia, we conducted a multicenter, retrospective study of lung cancer patients who underwent lung resection. METHODS: Between January 2014 and December 2016, a total of 721 patients underwent lung resections at 1 of the 6 hospitals included in our study. Among 721 patients, 280 (38.8%) received perioperative oral care, and the remaining 441 (61.2%) did not receive any such care. Propensity score matching was performed to minimize selection biases associated with the comparison of retrospective data between the oral care and control groups. RESULTS: Of the 721 patients, 54 (7.5%) experienced postoperative pneumonia involving 13 of the 280 patients (4.6%) in the oral care group and 41 of the 441 patients (9.3%) in the control group (P = .02). On propensity score analysis, a significant difference was also found between oral care intervention and incidence of postoperative pneumonia (P = .002). CONCLUSION: Our results suggest that perioperative oral care is an effective method to decrease the occurrence of postoperative pneumonia in patients who have undergone lung resection.2019年05月, Surgery, 165(5) (5), 1003 - 1007, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2019年05月, Photobiomodul Photomed Laser Surg, 37(3) (3), 175 - 81, 英語Clinical Evaluation of CO2 Laser Vaporization Therapy for Oral Lichen Planus: A Single-Arm Intervention Study.[査読有り]研究論文（学術雑誌）
- (一社)日本口腔ケア学会, 2019年04月, 日本口腔ケア学会雑誌, 13(3) (3), 120 - 120, 日本語多施設共同研究 高用量骨吸収抑制薬投与患者の抜歯と顎骨壊死発症 本学会共同研究委員会による多施設共同前向き研究の提案 抜歯例について
- (一社)日本口腔ケア学会, 2019年04月, 日本口腔ケア学会雑誌, 13(3) (3), 122 - 122, 日本語多施設共同研究 高用量骨吸収抑制薬投与患者の顎骨壊死発症予防法 本学会共同研究委員会による多施設共同前向き研究の提案 非抜歯例について
- BACKGROUND/AIM: We recently investigated the contribution of the iPS-related genes SOX2, OCT4, and Nanog to de-differentiation by assaying for their mRNA levels. Given that mRNA expression does not always correlate with the protein levels, the aim of this study was to retrospectively determine the expression of these four iPS-related factors in human OSCC specimens by immunohistochemistry and examine their association with patient prognosis. MATERIALS AND METHODS: iPS cell-related gene expression in 89 OSCC patients by tissue microarray, and its correlation with clinicopathological factors, differentiation, metastasis, and poor prognoses were investigated. RESULTS: No evidence of statistically significant relationships was found between the expression of iPS cell-related genes and clinicopathological parameters. However, our data indicated that KLF4 expression was associated with survival, and poor tumor differentiation. In addition, high expression of KLF4 was an independent poor prognostic factor (p=0.004) for OSCC patients. CONCLUSION: In preoperative biopsies, higher KLF4 and poor differentiation may be clinically effective predictors for the prognosis of oral cancer.2019年03月, Anticancer research, 39(3) (3), 1205 - 1216, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2019年03月, J Surg Oncol, 119(3) (3), 370 - 378, 英語[査読有り]研究論文（学術雑誌）
- BACKGROUND: This multicenter retrospective study aimed to determine whether elective neck dissection (END) can be performed for T1-2N0M0 tongue cancer. METHODS: Patients with T1-2N0M0 tongue squamous cell carcinoma who received treatment between January 2000 and December 2012 were enrolled at 14 multicenter study sites. The 5-year overall survival (OS) and 5-year disease-specific survival (DSS) were compared between the propensity score-matched END and observation (OBS) groups. RESULTS: The results showed that the OS rates among the 1234 enrolled patients were 85.5% in the END group and 90.2% in the OBS group (P = 0.182). The DSS rates were 87.0% in the END group and 94.3% in the OBS group (P = 0.003). Among the matched patients, the OS rates were 87.1% in the END group and 76.2% in the OBS group (P = 0.0051), and the respective DSS rates were 89.2% and 82.2% (P = 0.0335). CONCLUSION: This study showed that END is beneficial for T1-2N0M0 tongue cancer. However, END should be performed for patients with a tumor depth of 4-5 mm or more, which is the depth associated with a high rate of lymph node metastasis. The use of END should be carefully considered for both elderly and young patients.2019年02月, Annals of surgical oncology, 26(2) (2), 555 - 563, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2019年01月, Osteoporos Int, 30(1) (1), 231 - 239, 英語[査読有り]研究論文（学術雑誌）
- (一社)日本有病者歯科医療学会, 2018年12月, 有病者歯科医療, 27(6) (6), 495 - 495, 日本語MRONJ治療時の休薬の意義はあるか?
- (公社)日本顎顔面インプラント学会, 2018年11月, Japanese Journal of Maxillo Facial Implants, 17(3) (3), 224 - 224, 日本語当科におけるインプラント埋入症例と喪失リスク因子に関する後ろ向き観察研究
- BACKGROUND/AIM: Tumor lymphangiogenesis plays a key role in lymph node (LN) metastasis in oral squamous cell carcinoma (OSCC). The purpose of this study was to investigate podoplanin and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) and their relationship to nodal metastasis and other clinicopathological variables. PATIENTS AND METHODS: Podoplanin and LYVE-1 expression of the primary tumor and normal tissue were investigated by means of a quantitative real-time PCR assay and immunohistochemistry in samples from 33 cases of OSCC. RESULTS: The mRNA high expression levels of both genes had a statistically significantly higher rate of LN metastasis (p<0.01) and histological grade (p<0.01 for podoplanin, p<0.05 for LYVE-1). High expression of each gene, as shown by immunohistochemistry, had a statistically significant higher rate of LN metastasis (p<0.01 for podoplanin, p<0.05 for LYVE-1). CONCLUSION: Podoplanin and LYVE-1 were strongly associated with LN metastasis.2018年11月, Anticancer research, 38(11) (11), 6157 - 6162, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Enhancing the antitumor effect of radiation, while reducing damage to organs, is a significant challenge in radiation therapy for head and neck malignancies. One promising radiosensitizer is gold. The present study aimed to determine whether gold nanoparticles (AuNPs) have the potential to enhance the effects of X-ray irradiation on head and neck cancer cells. The human head and neck carcinoma cell line HSC-3 was used. Total cell number and the levels of cell proliferation and apoptosis were compared between control cells and cells treated with 5-nm AuNPs alone at four concentrations (0.1, 0.4, 1.0 and 10.0 nM), X-ray irradiation alone at three doses (2, 4 and 8 Gy), or a combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs. Analysis of variance and Tukey-Kramer testing were performed to compare the different groups. The total number of cells significantly decreased following 4 and 8 Gy X-ray irradiation, compared with in the control group (control vs. 4Gy, P=2.19×10-4; control vs. 8Gy, P=1.28×10-6). The combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs significantly reduced the total number of cells compared with 4 Gy X-ray irradiation alone (P=2.95×10-4). Cell proliferation was not affected by AuNP treatment alone, 4 Gy X-ray irradiation alone or the combination of X-ray irradiation and AuNPs. The combination of 4 Gy irradiation and 1.0 nM AuNPs significantly increased the number of apoptotic cells compared with 4 Gy irradiation alone (P=0.0261). In conclusion, AuNPs combined with X-ray irradiation enhanced the cytotoxic effect on human head and neck cancer cells in vitro, through the induction of apoptosis, but not inhibition of cell proliferation.2018年11月, Biomed Rep, 9(5) (5), 415 - 420, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- INTRODUCTION: Skin flap procedures are widely used to reconstruct skin and soft tissue defects. Skin flap necrosis is a serious postoperative complication. Many researchers have introduced pharmacological agents to improve flap ischemia in experimental studies. However, outcomes of these studies remain controversial. We previously demonstrated that transcutaneous CO2 application improves hypoxia in fracture repair. In this study, we hypothesized that improving hypoxia by transcutaneous CO2 application can improve the blood flow in skin flaps and increase angiogenesis. We investigated whether transcutaneous CO2 application can increase the survival of random-pattern skin flaps. MATERIALS AND METHODS: Six-week-old male Sprague-Dawley rats were divided into two equal groups: the control group (n = 6) and CO2 group (n = 6). A random-pattern skin flap was constructed in these rats. Topical CO2 was applied using a hydrogel every day for 5 days in the CO2 group. The flap survival area was measured on postoperative days 1, 3, and 5. The vessel density and expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and hypoxia-inducible factor-1α (HIF-1α) were evaluated on postoperative day 5. RESULTS: A statistically significant difference was found in the percentage of the flap survival area between the two groups on postoperative days 3 and 5 (p < 0.05). Furthermore, the expression of VEGF and bFGF was significantly higher and that of HIF-1α was significantly lower in the CO2 than in the control group (p < 0.05). CONCLUSIONS: Transcutaneous CO2 application can improve the blood flow in skin flaps and increase angiogenesis, thus increasing the survival of random-pattern skin flaps.2018年11月, Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 71(11) (11), 1644 - 1651, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)日本癌治療学会, 2018年10月, 日本癌治療学会学術集会抄録集, 56回, SY12 - 3, 英語希少がんである口腔癌を多方面から考える 早期舌癌における頸部後発転移に対する新規予測因子の検討
- (一社)日本癌治療学会, 2018年10月, 日本癌治療学会学術集会抄録集, 56回, P1 - 1, 英語癌患者の口腔機能管理の基準に関する多施設共同後ろ向き観察研究[査読有り]
- OBJECTIVE: Musculocutaneous flap reconstruction surgery is one of the standard procedures following head and neck cancer resection. However, no previous studies have classified flaps in terms of muscle and fat or examined them after long-term follow-up. The purpose of this study was to estimate the fat and muscle volume changes in musculocutaneous flaps during long-term follow-up. METHODS: We conducted a retrospective analysis of 35 patients after musculocutaneous flap reconstruction. The total, fat, and muscle volumes of the musculocutaneous flaps were measured using 3-dimensional images. Changes in flap volumes over time (1 month, 1 year [POY1], and 5 years [POY5] postoperatively) were assessed. Flap persistence was calculated using flap volumes at 1 month after reconstruction for reference. RESULTS: Flap persistence at POY5 was 42.0% in total, 64.1% in fat, and 25.4% in muscle. Muscle persistence was significantly decreased (p < 0.0001). In a multiple regression analysis, decreased body mass index (BMI) of ≥ 5% influenced fat persistence less than muscle persistence at POY1; however, there was no significant difference at POY5. Postoperative radiation therapy was associated with a significant decrease in total flap persistence at POY1 (p = 0.046) and POY5 (p = 0.0097). Muscle persistence significantly decreased at POY5 (p = 0.0108). Age significantly influenced muscle volume at POY1 (p = 0.0072). CONCLUSION: Reconstruction flaps are well-preserved with high fat-to-muscle ratios. Recommendations for weight maintenance are necessary for patients less than 2 years after surgery due to the influence of BMI on fat persistence. Radiation therapy is necessary for some patients based on their disease state. Intensity-modulated radiation therapy can be offered to reduce scattering irradiation to normal tissues.2018年09月, J Reconstr Microsurg, 35(4) (4), 235 - 243, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: A problematic complication after radiation therapy is lymphedema. Development of lymphedema is associated with an increase in lymphatic paracellular permeability. The current study investigated the effects of radiation on intercellular junctions and paracellular permeability in cultured human dermal lymphatic endothelial cells (HDLECs). METHODS AND RESULTS: Double immunofluorescence staining with vascular endothelial (VE)-cadherin and actin immediately after X-ray irradiation (5 or 20 Gy) was performed. Morphological changes induced by irradiation were assessed. Cell viability and paracellular permeability after irradiation were also evaluated. Broad junctions in which VE-cadherin was accumulated at cell-cell contacts and almost colocalized with actin were significantly decreased in a dose-dependent manner in confluent and sparse irradiated HDLECs. Irradiation shortened the width of VE-cadherin-positive areas at the cell-cell contacts. Actin filaments did not colocalize with VE-cadherin after 20 Gy irradiation. Although cell viability was not affected by irradiation, paracellular permeability significantly increased in a dose-dependent manner. CONCLUSIONS: A dose of 5 or 20 Gy irradiation in HDLECs does not affect cell viability, but changes VE-cadherin mediated intercellular junctions and actin structure, resulting in an increase of paracellular permeability. Further investigations on the regulatory proteins involved in radiation-induced changes, which were observed in the current study, may contribute to development of lymphedema therapy.2018年08月, Lymphat Res Biol, 16(4) (4), 390 - 396, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Radiotherapy (RT) is one of the main treatment modalities for oral squamous cell carcinoma (OSCC), however, radioresistance is a major impediment to its clinical success and poses as a concern that needs to be addressed. Tumor hypoxia is known to be significantly associated with radioresistance in various malignancies, hence, resolving the hypoxic state of a tumor may improve the antitumor effect of RT on OSCC. We have previously revealed that transcutaneous CO2 induced mitochondrial apoptosis and suppressed tumor growth in OSCC by resolving hypoxia. Considering the previous study, we hypothesized that transcutaneous CO2 may enhance the antitumor effect of RT on OSCC by improving intratumoral hypoxia, thereby overcoming radioresistance. In the present study, the combination of transcutaneous CO2 and RT significantly inhibited tumor growth compared with other treatments. This combination therapy also led to decreased expression of HIF-1α in parallel with increased expression of the cleaved forms of caspase-3-8-9 and PARP, which play essential roles in mitochondrial apoptosis. Additionally, the combination therapy increased the expression of ROS modulator 1 and subsequent mitochondrial ROS production, compared to RT alone. These results indicated that transcutaneous CO2 could potentially improve the antitumor effect of RT by decreasing the intratumoral hypoxia and increasing the mitochondrial apoptosis. Our findings indicated that CO2 therapy may be a novel adjuvant therapy in combination with RT for OSCC.2018年07月, Oncology reports, 40(1) (1), 434 - 442, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Oral squamous cell carcinoma (OSCC) containing single lymph node metastasis (pN1) with extra nodal extension (ENE) is a rare clinical situation. Therefore, it is unclear whether pN1 with ENE is at high risk of recurrence among the OSCC population, or whether postoperative radiotherapy (RT)/concomitant chemoradiotherapy (CCRT) is effective in these cases. OBJECTIVES: The purpose of this retrospective study was to investigate the prognosis and compare between no postoperative therapy and postoperative RT/CCRT in pN1 with ENE OSCC patients. METHODS: Clinicopathological data and treatment modalities were investigated. The evaluated endpoints were overall survival (OS) and type of recurrence. RESULTS: The 3-year cumulative OS rates for the pN1 only, multiple lymph node metastasis (MLM) only, ENE + MLM, and ENE + pN1 groups were 77.2%, 66.8%, 43.3%, and 66.6%, respectively. In the ENE + pN1 group, the most common cause of death in the surgery only group was from regional failure. The surgery + RT/CCRT group was associated with better disease-specific survival and OS rates than the surgery only groups (P < 0.05). CONCLUSIONS: The prognosis of ENE + pN1 was not as poor as that of ENE + MLM, although both these groups feature ENE. Adjuvant therapy (RT/CCRT) after surgery is recommend for cases of ENE + pN1.2018年06月, J Surg Oncol, 117(8) (8), 1736 - 1743, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- W.B. Saunders, 2018年02月, Journal of Oral and Maxillofacial Surgery, 76(2) (2), 304 - 313, 英語[査読有り]研究論文（学術雑誌）
- 2018年01月, Int J Oral Maxillofac Surg, 47(6) (6), 794 - 801, 英語[査読有り]研究論文（学術雑誌）
- Mosby Inc., 2018年, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 126(3) (3), 264 - 71, 英語[査読有り]研究論文（学術雑誌）
- Springer Verlag, 2017年12月, Oral and Maxillofacial Surgery, 21(4) (4), 397 - 404, 英語[査読有り]研究論文（学術雑誌）
- A Case Series of Fibro-Osseous Lesions of the Jaws.The aim of this case series was to reveal the difficulties in diagnosing fibro-osseous lesions with radiological and histopathological examinations and quantify the potential risk of infection to fibro-osseous legions. To analyze the concordance between radiological and histopathological diagnoses, this retrospective case series included patients who were clinically diagnosed with fibro-osseous lesions via radiological findings and excluded the patients who did not undergo histopathological examinations. This study also included the patients in whom histopathological results confirmed fibro-osseous legions when preoperative radiological diagnosis did not include fibro-osseous legions. Eleven patients (three men, eight women; median age 24.5 years, range 15-57 years) were enrolled. Although radiological diagnoses of fibrous dysplasia (FD) corresponded with histopathological diagnoses in seven patients, mismatches between radiological findings and histopathological results were found in three patients. In one patient, suspected diagnosis with radiological examinations was malignant lymphoma or FD. In two patients, the histopathological differentiation between FD and ossifying fibroma (OF) was difficult. One patient had lesion recurrence which was suspected to be OF with surgical findings and postoperative course after the initial surgery. In three patients, infections of FD were found. Preoperative diagnosis of OF with radiographic feature of unilocular radiolucency is difficult. In cases in which histopathological differentiation between FD and OF is difficult, operative findings should be used because OF is often found to be well-encapsulated and easily enucleated. Bone in FD showing mixed radiolucent-radiopaque may be vulnerable to infection.2017年12月, Kobe J Med Sci, 63(3) (3), E73 - 79, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- 2017年11月, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 45(11) (11), 1778 - 1783, 英語[査読有り]研究論文（学術雑誌）
- (一社)日本癌治療学会, 2017年10月, 日本癌治療学会学術集会抄録集, 55回, PS - 1, 日本語早期舌扁平上皮癌における頸部後発転移の新たな予測因子の検討
- 2017年10月, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 32(10) (10), 2022 - 2029, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- OBJECTIVES: The progression level of extracapsular spread (ECS) for cervical lymph node metastasis of oral squamous cell carcinoma (OSCC) was previously divided into three types, and their relationships with the prognosis of patients were re-examined. PATIENTS AND METHODS: The Kaplan-Meier method was used to examine overall survival (OS) and relapse-free survival (RFS) curves. Prognosis factor for recurrence was analyzed with univariate and multivariate analysis. RESULTS: ECS was detected in 216 cases of OSCC and analyzed. The 5-year overall survival and RFS rates of patients with type C, which was microscopically defined as tumor invasion to perinodal fat or muscle tissue, were significantly poor at 40.6 and 37.8%, respectively. The results of a univariate analysis suggested that the prognosis of ECS in OSCC patients is associated with its progression level, particularly type C. The 5-year RFS rate of type C with tumor budding was significantly poor at 31.5%. Type C with tumor budding correlated with local and regional recurrence as well as distant metastasis. In a multivariate analysis, tumor budding was identified as an independent prognostic factor. CONCLUSIONS: These results suggest that the progression level of ECS and tumor budding are useful prognostic factors in OSCC patients. CLINICAL RELEVANCE: This study indicated that the progression level and tumor budding of ECS for cervical lymph node metastasis were useful prognostic factors in OSCC patients.2017年10月, Clin Oral Investig, 22(3) (3), 1311 - 1318, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2017年10月, JOURNAL OF BONE AND MINERAL RESEARCH, 32(10) (10), 2022 - 2029, 英語[査読有り]研究論文（学術雑誌）
- (公社)日本顎顔面インプラント学会, 2017年08月, Japanese Journal of Maxillo Facial Implants, 16(2) (2), 75 - 80, 日本語インプラント周囲に放射線性顎骨壊死を生じ保存的に治療した1例[査読有り]研究論文（学術雑誌）
- 2017年08月, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 124(2) (2), 139 - 145, 英語[査読有り]研究論文（学術雑誌）
- 2017年08月, MEDICINE, 96(33) (33), e7436, 英語[査読有り]研究論文（学術雑誌）
- 2017年08月, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 14(2) (2), 953 - 960, 英語[査読有り]研究論文（学術雑誌）
- 2017年08月, OSTEOPOROSIS INTERNATIONAL, 28(8) (8), 2465 - 2473, 英語[査読有り]研究論文（学術雑誌）
- (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66(2) (2), 81 - 81, 日本語ARONJの新たな医科歯科連携 抜歯と骨吸収抑制薬関連性顎骨壊死に関する多施設共同後ろ向き研究 抜歯前休薬の有無と術中処置について
- (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66(2) (2), 81 - 82, 日本語ARONJの新たな医科歯科連携 薬剤関連顎骨壊死(MRONJ)の治療成績に影響する因子に関する多施設共同後ろ向き観察研究
- (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66(2) (2), 110 - 111, 日本語早期舌癌における再発予測因子としてのTumor Buddingの検討
- 2017年07月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 75(7) (7), 1338 - 1343, 英語[査読有り]研究論文（学術雑誌）
- BACKGROUND: This study aimed to evaluate posttreatment soft-tissue changes in patients with oral cancer with computed tomography (CT). To accomplish that purpose, a scoring system was established, referring to the criteria of lower leg lymphedema (LE). METHODS AND RESULTS: One hundred and six necks in 95 patients who underwent oral oncologic surgery with neck dissection (ND) were analyzed retrospectively using routine follow-up CT images. A two-point scoring system to evaluate soft-tissue changes (so-called "LE score") was established as follows: Necks with a "honeycombing" appearance were assigned 1 point. Necks with "taller than wide" fat lobules were assigned 1 point. Necks with neither appearance were assigned 0 points. Comparisons between patients with LE score ≥1 and LE score = 0 at 6 months postoperatively were performed using the Fisher exact test for discrete variables and the Mann-Whitney U test for continuous variables. Univariate predictors associated with posttreatment changes (i.e., LE score ≥1 at 6 months postoperatively) were entered into a multivariate logistic regression analysis. Values of p < 0.05 were considered to indicate statistical significance. The occurrence of the posttreatment soft-tissue changes was 32%. Multivariate logistic regression analysis showed that postoperative radiation therapy (RT) and bilateral ND were potential risk factors of posttreatment soft-tissue changes on CT images. CONCLUSIONS: Sequential evaluation of "honeycombing" and the "taller than wide" appearances on routine follow-up CT revealed the persistence of posttreatment soft-tissue changes in patients who underwent oral cancer treatment, and those potential risk factors were postoperative RT and bilateral ND.2017年07月, Lymphat Res Biol, 16(2) (2), 147 - 153, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Resection of buccal mucosa tumors may occasionally involve the labial angle and peripheral skin. Reconstruction is required when the resection involves more than one-third of the lip. We describe a single-stage reconstruction using a facial artery musculomucosal (FAMM) flap and a vermilion advancement flap after buccal mucosa resection including the labial angle. A 62-year-old woman with carcinoma in situ of the buccal mucosa underwent tumor resection. The resection included the right labial angle and peripheral skin. The resection did not lead to a massive lip defect, but a wide defect resulted on the mucosal side. The defect on the mucosal side was reconstructed using a FAMM flap, while the vermilion defect was covered using a vermilion advancement flap. Reconstruction performed using the FAMM flap and vermilion advancement flap produced aesthetically and functionally satisfactory outcomes.2017年06月, J Surg Case Rep, 2017(6) (6), rjx108, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Endurance exercise generates CO2 via aerobic metabolism; however, its role remains unclear. Exogenous CO2 by transcutaneous delivery promotes muscle fibre-type switching to increase endurance power in skeletal muscles. Here we determined the performance of rats running in activity wheels with/without transcutaneous CO2 exposure to clarify its effect on endurance exercise and recovery from muscle fatigue. Rats were randomised to control, training and CO2 groups. Endurance exercise included activity-wheel running with/without transcutaneous CO2 delivery. Running performance was measured after exercise initiation. We also analysed changes in muscle weight and muscle fibres in the tibialis anterior muscle. Running performance improved over the treatment period in the CO2 group, with a concomitant switch in muscle fibres to slow-type. The mitochondrial DNA content and capillary density in the CO2 group increased. CO2 was beneficial for performance and muscle development during endurance exercise: it may enhance recovery from fatigue and support anabolic metabolism in skeletal muscles.2017年06月, J Physiol Sci, 68(4) (4), 463 - 470, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- (NPO)日本顎変形症学会, 2017年05月, 日本顎変形症学会雑誌, 27(2) (2), 125 - 125, 日本語
- (一社)日本頭頸部癌学会, 2017年05月, 頭頸部癌, 43(2) (2), 189 - 189, 日本語神経症状を伴った下顎放射線性顎骨壊死における下歯槽神経の病理組織学的研究
- Elsevier Ltd, 2017年05月, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 29(3) (3), 217 - 221, 英語[査読有り]研究論文（学術雑誌）
- Mosby Inc., 2017年05月, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 123(5) (5), 524 - 530, 英語[査読有り]研究論文（学術雑誌）
- 2017年03月, Anticancer Research, 37(3) (3), 1075 - 1082, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2017年02月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 46(2) (2), 267 - 273, 英語[査読有り]研究論文（学術雑誌）
- 2017年01月, PLOS ONE, 12(1) (1), e0169723, 英語[査読有り]研究論文（学術雑誌）
- 2017年01月, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 45(1) (1), 145 - 149, 英語[査読有り]研究論文（学術雑誌）
- Bentham Science Publishers B.V., 2016年12月, Open Dentistry Journal, 10, 728 - 732, 英語[査読有り]研究論文（学術雑誌）
- A multi-institutional study was undertaken to determine whether mandibular canal (MC) invasion and mandibular medullary bone invasion are independent factors in lower gingival squamous cell carcinoma (SCC). A total of 345 patients with lower gingival SCC were retrospectively reviewed. Mandibular bone invasion was categorized into three types; no bone invasion; invasion through cortical bone (medullary); and MC invasion. The overall survival rate and factors affecting local, regional, and distant failures were assessed by Cox proportional hazards regression analysis and Kaplan-Meier estimates. Bone invasion was present in 201 (58%) patients, of whom 107 (31%) had medullary invasion and 94 (27%) had MC invasion. Using the International Union Against Cancer (UICC) staging system and American Joint Committee on Cancer (AJCC) system, 171 (50%) patients were classified as T4a. When the bone invasion criteria were excluded from the UICC/AJCC system definition, 152 T4a tumors were downstaged and reclassified to T1 in 12 (3%), to T2 in 98 (28%), and to T3 in 42 (12%). In Cox multivariate analysis, MC invasion was an independent predictor of overall survival but medullary bone invasion was not. Medullary bone invasion was an independent variable for distant control. The current T staging system has restricted prognostic utility. The authors recommend a modified T staging system, whereby tumors with MC invasion instead of medullary bone invasion are classified as T4a, and tumors are first classified as T1 to T3 based on size and then upstaged by one T classification in the presence of medullary invasion.2016年12月, Cancer medicine, 5(12) (12), 3378 - 3385, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (公社)日本顎顔面インプラント学会, 2016年11月, Japanese Journal of Maxillo Facial Implants, 15(3) (3), 218 - 218, 日本語当科におけるインプラント埋入症例と喪失リスクに関する臨床的検討
- (一社)日本癌治療学会, 2016年10月, 日本癌治療学会学術集会抄録集, 54回, PS - 2, 日本語T1-2N0M0舌扁平上皮癌の検討
- Springer Verlag, 2016年09月, Oral and Maxillofacial Surgery, 20(3) (3), 233 - 237, 英語[査読有り]研究論文（学術雑誌）
- 2016年08月, SURGICAL INFECTIONS, 17(4) (4), 479 - 484, 英語研究論文（学術雑誌）
- (NPO)日本顎変形症学会, 2016年08月, 日本顎変形症学会雑誌, 26(3号) (3号), 243 - 254, 日本語[査読有り]研究論文（学術雑誌）
- 2016年08月, HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 38(8) (8), 1170 - 1175, 英語[査読有り]研究論文（学術雑誌）
- (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65(2) (2), 176 - 177, 日本語当科における埋伏智歯抜歯後神経系合併症に対する治療法の現状
- (一社)日本外傷歯学会, 2016年07月, 日本外傷歯学会総会・学術大会プログラム・抄録集, 16回, 41 - 41, 日本語下顎骨骨折の治療を行ったLennox-Gastaut症候群患児の1例
- (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65(2) (2), 176 - 176, 日本語抗血栓療法患者の抜歯後出血危険因子についての多施設共同研究
- (NPO)日本顎変形症学会, 2016年05月, 日本顎変形症学会雑誌, 26(2) (2), 181 - 181, 日本語
- (一社)日本頭頸部癌学会, 2016年05月, 頭頸部癌, 42(2) (2), 147 - 147, 日本語歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価
- (NPO)日本顎変形症学会, 2016年05月, 日本顎変形症学会雑誌, 26(2) (2), 183 - 183, 日本語
- (一社)日本頭頸部癌学会, 2016年05月, 頭頸部癌, 42(2) (2), 169 - 169, 日本語口腔扁平上皮癌における術後補助療法の指標となる頸部リンパ節転移の被膜外浸潤の進展度分類の検討
- (一社)日本頭頸部癌学会, 2016年05月, 頭頸部癌, 42(2) (2), 179 - 179, 日本語下歯肉がんのT分類(多施設共同後ろ向き研究JOOG RA-1401)
- (一社)日本頭頸部癌学会, 2016年05月, 頭頸部癌, 42(2) (2), 204 - 204, 日本語口腔癌病理学的再発高リスク例に対する術後補助療法の検討
- 2016年05月, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 44(5) (5), 637 - 641, 英語[査読有り]研究論文（学術雑誌）
- Oral squamous cell carcinoma (OSCC) is the most common form of oral cancers. Recent studies have shown that the malignant transformation of various carcinomas, including OSCC, is associated with epithelial-mesenchymal transition (EMT), and that expression of the EMT factors are significantly associated with tumor invasion, tumor metastasis, and survival rates in OSCC patients. Hence, there is a possibility that EMT suppression may improve the prognosis of OSCC patients. Hypoxia inducible factor-1α (HIF-1α) is a crucial microenvironmental factor in tumor progression, which induces the expression of EMT factors. We previously reported that transcutaneous CO2 suppresses both human OSCC tumor growth and metastasis to the regional lymph nodes by improving hypoxia in treated tissue. According to this background, we hypothesized that increased EMT with HIF-1α expression may increase the progression and the metastatic potential of OSCC, and that decreased hypoxia by transcutaneous CO2 could suppress EMT. In the present study, in vitro studies showed that hypoxic conditions increased the expression of HIF-1α and EMT factors in OSCC cells. In addition, in vivo studies revealed that transcutaneous CO2 increased E-cadherin expression with the decreased expression of HIF-1α, Snail, Slug, N-cadherin, and Vimentin in tumor treatment. These results suggest that transcutaneous CO2 could suppress EMT by improving hypoxia, resulting in the reduction of metastatic potential of OSCC. The findings indicate that transcutaneous CO2 may be able to improve the prognosis of OSCC patients through the suppression of EMT.2016年04月, International journal of oncology, 48(4) (4), 1493 - 8, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)日本口腔ケア学会, 2016年03月, 日本口腔ケア学会雑誌, 10(1) (1), 199 - 199, 日本語当科における心臓血管外科周術期の口腔機能管理に関する実態と今後の課題
- (一社)日本口腔ケア学会, 2016年03月, 日本口腔ケア学会雑誌, 10(1) (1), 225 - 225, 日本語当院における周術期口腔機能管理に関する実態調査と今後の課題
- 2016年02月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 45(2) (2), 141 - 146, 英語[査読有り]研究論文（学術雑誌）
- Kobe University School of Medicine, 2016年, Kobe Journal of Medical Sciences, 62(5) (5), E114 - E119, 英語Meaning and limitation of cortical bone width measurement with DentaScan in medication-related osteonecrosis of the jaws[査読有り]研究論文（学術雑誌）
- 2016年, 日本口腔科学会誌, 65, 324-329食道がん術後肺炎予防に対する周術期口腔機能管理の有効性 多施設共同後ろ向き研究による検証.[査読有り]
- 2016年, IMPLANT DENTISTRY, 25(5) (5), 715 - 719, 英語[査読有り]研究論文（学術雑誌）
- 2016年, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology., 28, 111 - 117, 日本語[査読有り]研究論文（学術雑誌）
- 2016年01月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 74(1) (1), 212 - 217, 英語[査読有り]研究論文（学術雑誌）
- 2015年11月, Japanese Journal of Maxillo Facial Implants, 14(3号) (3号), 261, 日本語ロケーター・磁性バーアタッチメントによるインプラントオーバーデンチャー関連合併症研究論文（その他学術会議資料等）
- 2015年10月, IMPLANT DENTISTRY, 24(5) (5), 541 - 546, 英語[査読有り]研究論文（学術雑誌）
- (一社)日本癌治療学会, 2015年09月, 日本癌治療学会誌, 50(3) (3), 2196 - 2196, 日本語頭頸・口腔 口腔がん治療の個別化を目指して 下歯肉・下顎癌のUICC分類と下顎管分類に関する多施設共同後ろ向き研究JOOG RA-1401
- 2015年09月, 日本口腔科学会雑誌, 64(3号) (3号), 301, 日本語放射線治療後の甲状腺機能低下による低ナトリウム血症の1例研究論文（その他学術会議資料等）
- 2015年09月, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 43(7) (7), 1094 - 1098, 英語[査読有り]研究論文（学術雑誌）
- 2015年08月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(8) (8), 942 - 947, 英語[査読有り]研究論文（学術雑誌）
- 2015年08月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(8) (8), 977 - 983, 英語[査読有り]研究論文（学術雑誌）
- 2015年07月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(7) (7), 929 - 935, 英語[査読有り]研究論文（学術雑誌）
- 口腔癌患者への緩和ケアチーム（PCT）の介入についての臨床的検討を行った。対象は2008年1月から2012年10月に神戸大学病院歯科口腔外科で加療を行った口腔癌患者194例のうち，PCTの介入を行った36例である。依頼理由は，疼痛，不眠，不安が多く71.1%を占めていた。介入開始時および終了時に，患者の有する症状についてSTAS-J症状版を用いて評価した。22項目中21項目で改善を認め，13項目で有意なスコアの低下を認めた。よって，PCTの介入は有用であったことが示された。口腔癌患者特有の問題として，容姿の変形，摂食嚥下障害，構音障害などが挙げられる。PCTと連携し，治療過程の早期から患者の持つ様々な症状の緩和に努めることが重要である。一般社団法人 日本口腔腫瘍学会, 2015年06月, 日本口腔腫瘍学会誌, 27(2号) (2号), 13 - 20, 日本語[査読有り]研究論文（学術雑誌）
- 2015年06月, OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 152(6) (6), 1053 - 1060, 英語[査読有り]研究論文（学術雑誌）
- 2015年06月, J Surg Case Rep, 6, 1 - 4, 英語Facial emphysema after sinus lift[査読有り]研究論文（学術雑誌）
- 2015年05月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 73(5) (5), 1003 - 1007, 英語[査読有り]研究論文（学術雑誌）
- (一社)日本口腔感染症学会, 2015年05月, 日本口腔感染症学会雑誌, 22(1号) (1号), 41 - 42, 日本語抗RANKLモノクローナル抗体(デノスマブ)投与患者に発症した顎骨壊死の1例研究論文（その他学術会議資料等）
- 2015年05月, 日本顎変形症学会雑誌, 25(2号) (2号), 117, 日本語外科的矯正手術前後における顎関節症状および顎関節MRI画像の変化研究論文（その他学術会議資料等）
- 2015年05月, 日本顎変形症学会雑誌, 25(2号) (2号), 134, 日本語下顎枝垂直骨切り術後の近位骨片と下顎頭変化の評価研究論文（その他学術会議資料等）
- 2015年04月, JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 44, 13, 英語[査読有り]研究論文（学術雑誌）
- We investigated changes in the sensitivity of cutaneous points and the oral mucosa after sagittal split ramus osteotomy (SSRO) and assessed the differences between SSRO and intraoral vertical ramus osteotomy (IVRO). The subjects included in this study were 46 patients with mandibular prognathism who underwent IVRO (88 rami) and 30 patients who underwent SSRO (59 rami). An objective evaluation of the neurosensory status of each patient was completed preoperatively and at 1, 4, 8, 12, and 24 weeks postoperatively. Other variables studied for each patient included sex, age, magnitude of mandibular setback, and amount of blood loss during surgery. We found that a neurosensory recovery occurred earlier in the oral mucosa than at cutaneous points. The number of oral mucosa points showing reduced neurosensory function and neurosensory disturbance after SSRO was significantly higher than after IVRO at 1, 4, and 8 weeks (P<0.05). The nerve recovery observed after SSRO was delayed for a longer period than that noted in our previous study of IVRO. In conclusion, we found changes in sensitivity at cutaneous points and the oral mucosa after SSRO and assessed the differences between SSRO and IVRO.2015年03月, International journal of oral and maxillofacial surgery, 44(3) (3), 349 - 55, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2015年03月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(3) (3), 412 - 416, 英語[査読有り]研究論文（学術雑誌）
- (一社)日本口腔腫瘍学会, 2015年03月, 日本口腔腫瘍学会誌, 27(1) (1), 1 - 6, 日本語後方への進展なくルビエールリンパ節に転移を生じた口腔癌2例[査読有り]研究論文（学術雑誌）
- Kobe University School of Medicine, 2015年, Kobe Journal of Medical Sciences, 61(3) (3), E64 - E70, 英語Spindle cell carcinoma of the oral cavity: The impact of chemotherapy on pulmonary metastatic tumor doubling time[査読有り]研究論文（学術雑誌）
- 2015年, J Oral Maxillofac Surg Med Pathol, 英語Evaluation and comparison of CT values in bisphosphonate-related osteonecrosis of the jaw[査読有り]研究論文（学術雑誌）
- Kobe University School of Medicine, 2015年, Kobe Journal of Medical Sciences, 61(4) (4), E102 - E108, 英語Clinical study of 19 cases resulting in dental implant removal[査読有り]研究論文（学術雑誌）
- 2015年01月, 日本口腔外科学会雑誌, 61(1号) (1号), 25 - 30, 日本語急速に増大し巨舌を呈した多発性骨髄腫に伴うアミロイドーシスの1例[査読有り]研究論文（学術雑誌）
- (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 128 - 128, 日本語当科における広範囲顎骨支持型インプラント補綴の臨床統計的検討
- (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 144 - 144, 日本語著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った1例
- (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 160 - 160, 日本語当科におけるインプラント242例907本埋入に関する臨床的検討
- (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 166 - 166, 日本語歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価
- 2014年10月, Osteoporosis Japan, 22(4) (4), 706 - 709, 日本語ゾレドロネート反復投与による創傷治癒遅延の予防、治療法に関する研究研究論文（学術雑誌）
- Cystadenocarcinoma is an uncommon salivary gland tumor that occurs in the palate. We report a rare case of cystadenocarcinoma arising in the palate. A 80-year-old man visited a certain hospital because of a painless swelling in the palate. A biopsy was performed, and adenocarcinoma was diagnosed histopathologically. He was therefore referred to our hospital to receive treatment for adenocarcinoma. He had a painless swelling, measuring 25 × 15 mm, in the left side of the palate. Computed tomography showed no evidence of cervical metastasis. Partial maxillectomy was performed, and the final histopathological diagnosis was cystadenocarcinoma. There was no evidence of recurrence or metastasis 20 months after the operation.Japanese Society of Oral and Maxillofacial Surgeons, 2014年10月, 日本口腔外科学会雑誌, 60(10号) (10号), 561 - 565, 日本語[査読有り]研究論文（学術雑誌）
- (NPO)日本口腔科学会, 2014年09月, 日本口腔科学会雑誌, 63(4) (4), 381 - 381, 日本語口腔癌再建術後の頸部感染評価目的でのCTの有用性
- 2014年09月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43(9) (9), 1104 - 1107, 英語[査読有り]研究論文（学術雑誌）
- 2014年09月, LYMPHATIC RESEARCH AND BIOLOGY, 12(3) (3), 136 - 143, 英語[査読有り]研究論文（学術雑誌）
- 2014年08月, 日本顎変形症学会雑誌, 24(3号) (3号), 253 - 258, 日本語周術期のD2受容体阻害薬投与が誘因となり急性ジストニアを発症したと考えられた顎変形症患者の1例[査読有り]研究論文（学術雑誌）
- 2014年07月, PLOS ONE, 9(7) (7), e100530, 英語[査読有り]研究論文（学術雑誌）
- 2014年06月, Oral Health Dent Manag, 13(2) (2), 507 - 11, 英語Sequential changes in oral dryness evaluated by a moisture-checking device in patients with oropharyngeal cancer during chemoradiotherapy: a pilot study[査読有り]研究論文（学術雑誌）
- (NPO)日本顎変形症学会, 2014年05月, 日本顎変形症学会雑誌, 24(2) (2), 115 - 115, 日本語
- 2014年04月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43(4) (4), 387 - 392, 英語[査読有り]研究論文（学術雑誌）
- 2014年03月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43(3) (3), 367 - 372, 英語[査読有り]研究論文（学術雑誌）
- Retrospective study of ameloblastoma: the possibility of conservative treatment.At our institutions, most cases of the solid or multicystic type were treated as conservatively as possible in order to avoid disadvantages of radical treatment. The aim of present study was to retrospectively analyze the ameloblastoma cases diagnosed at our two institutions, to classify them according to the criteria of the 2005 WHO classification, and to evaluate the possibility of using a conservative approach for the surgical treatment of ameloblastoma. Maxillary cases, unicystic cases, peripheral cases and resection-treated cases were excluded from this study. In 23 tumors of mandibular solid or multicystic ameloblastoma, a patient's age, gender, location, clinical signs, duration, radiographic appearance, preoperative diagnosis, ameloblastoma subtypes, treatment, and recurrence were investigated. The recurrence rate (48.7%) in this study was lower than the reported recurrence rate after conservative treatment for solid or multicystic ameloblastoma and was higher than the reported recurrence rate of ameloblastoma, inclusive of other types. However, all patients who were diagnosed with recurrences have maintained their quality of life and were satisfied for at least several years after the conservative treatment. In conclusion, we demonstrated one possibility that a conservative approach might be employed in the surgical treatment of ameloblastoma (even of the solid or multicystic type).2013年11月, The Kobe journal of medical sciences, 59(4) (4), E112-21 - 21, 英語, 国内誌[査読有り]研究論文（大学，研究機関等紀要）
- 2013年11月, Japanese Journal of Maxillo Facial Implants, 12(3号) (3号), 151, 日本語当科におけるインプラントの撤去に至った20例の臨床的検討研究論文（その他学術会議資料等）
- 2013年11月, Japanese Journal of Maxillo Facial Implants, 12(3号) (3号), 115, 日本語下顎のスプリットクレスト法において遊離骨片が生じた6例の臨床的検討研究論文（その他学術会議資料等）
- 2013年11月, Japanese Journal of Maxillo Facial Implants, 12(3号) (3号), 141, 日本語CT画像における下顎舌側にみられる骨孔の観察研究論文（その他学術会議資料等）
- 2013年11月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 42(11) (11), 1454 - 1461, 英語[査読有り]研究論文（学術雑誌）
- 2013年09月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 71(9) (9), 1602, 英語[査読有り]研究論文（学術雑誌）
- 2013年07月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 42(7) (7), 843 - 851, 英語[査読有り]研究論文（学術雑誌）
- 2013年07月, Journal of Oral Rehabilitation, 40(7) (7), 484 - 490, 英語[査読有り]研究論文（学術雑誌）
- (NPO)日本顎変形症学会, 2013年05月, 日本顎変形症学会雑誌, 23(2) (2), 174 - 174, 日本語外科的矯正治療により咬合改善を得た上下顎の歯数不調和を伴う下顎骨骨折変形治癒症例研究論文（その他学術会議資料等）
- 2013年05月, 日本顎変形症学会雑誌, 23(2号) (2号), 93, 日本語下顎枝垂直骨切り術における骨性治癒形態の経時的観察研究論文（その他学術会議資料等）
- 2013年05月, 日本顎変形症学会雑誌, 23(2号) (2号), 174, 日本語53歳下顎側方偏位症例に対し外科的矯正治療を行った1例[査読有り]研究論文（その他学術会議資料等）
- 2013年04月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 71(4) (4), 793 - 797, 英語[査読有り]研究論文（学術雑誌）
- 2013年03月, JOURNAL OF ORAL REHABILITATION, 40(3) (3), 191 - 198, 英語[査読有り]研究論文（学術雑誌）
- 2013年, J Craniomaxillofac Surg., 41(7) (7), 558 - 563.研究論文（学術雑誌）
- Dedifferentiated carcinoma is defined as the abrupt transformation of a low-grade, well-differentiated tumor into a tumor of high malignancy. Because the transformed cells are highly aggressive, recurrence and metastasis frequently occur.Japanese Society of Oral and Maxillofacial Surgeons, 2013年, 日本口腔外科学会誌, 59(9) (9), 588 - 592, 日本語
We report a case of dedifferentiated carcinoma in adenoid cystic carcinoma of the submandibular gland with multiple metastases to the cervical lymph nodes and distant metastasis to the ileum.
A 73-year-old woman was referred to our hospital because of submandibular gland carcinoma with multiple lymph node metastases. In another clinic, adenocarcinoma was pathologically diagnosed on lymph node biopsy. A surgically resected specimen showed that the tumor was composed of both a cribriform pattern of conventional low-grade adenoid cystic carcinoma and a high-grade dedifferentiated carcinoma. The lesion was thus a dedifferentiated carcinoma. Lymph node metastases contained dedifferentiated components. One year and a half after the operation, the tumor metastasized to the small intestine (ileum) . The tumor in the ileum was also pathologically diagnosed as a high-grade dedifferentiated carcinoma.[査読有り]研究論文（学術雑誌） - 2012年08月, 日本顎変形症学会雑誌, 22(3号) (3号), 216 - 222, 日本語下顎枝垂直骨切り術における骨性治癒形態の経時的観察[査読有り]研究論文（学術雑誌）
- 2012年07月, 日本口腔科学会雑誌, 61(3号) (3号), 316, 日本語口蓋に発生した嚢胞腺癌の1例[査読有り]研究論文（その他学術会議資料等）
- 2012年05月, 日本顎変形症学会雑誌, 22(2号) (2号), 107, 日本語下顎枝垂直骨切り術術後における口腔内・口腔外知覚神経麻痺の経時的変化に関する検討[査読有り]研究論文（その他学術会議資料等）
- 2012年03月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 70(3) (3), 599 - 607, 英語[査読有り]研究論文（学術雑誌）
- (NPO)日本口腔科学会, 2012年01月, 日本口腔科学会雑誌, 61(1) (1), 131 - 132, 日本語
- (NPO)日本口腔科学会, 2012年01月, 日本口腔科学会雑誌, 61(1号) (1号), 1 - 7, 日本語[査読有り]研究論文（学術雑誌）
- 2012年01月, 日本口腔科学会雑誌, 61(1号) (1号), 150, 日本語抗凝固療法継続下で抜歯を施行した患者の出血性合併症に関する臨床的検討[査読有り]研究論文（その他学術会議資料等）
- 2012年, Kobe J Med Sci, 58(1) (1), E19 - E28, 英語Analysis of the 619 Brånemark System TiUnite implants: a retrospective study[査読有り]研究論文（学術雑誌）
- (公社)日本口腔外科学会, 2011年06月, 日本口腔外科学会雑誌, 57(6) (6), 355 - 359, 日本語
- 2011年06月, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 111(6) (6), E1 - E7, 英語[査読有り]研究論文（学術雑誌）
- 2011年05月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 40(5) (5), 475 - 482, 英語研究論文（学術雑誌）
- 2011年04月, Biochemical and biophysical research communications, 407(1) (1), 148 - 152, 英語[査読有り]研究論文（学術雑誌）
- (NPO)日本口腔科学会, 2011年01月, 日本口腔科学会雑誌, 60(1) (1), 60 - 60, 日本語
- (NPO)日本口腔科学会, 2011年01月, 日本口腔科学会雑誌, 60(1) (1), 84 - 85, 日本語
- (NPO)日本口腔科学会, 2011年01月, 日本口腔科学会雑誌, 60(1) (1), 186 - 186, 日本語
- (一社)日本有病者歯科医療学会, 2010年12月, 有病者歯科医療, 19(3) (3), 197 - 198, 日本語ミニシンポジウム/抗血栓療法 抗血栓療法継続下での歯科観血的処置後の出血の現状と対策
- The patient was a 63-year-old woman with a history of diabetes. At initial diagnosis, blood tests suggested the presence of severe infection because the while cell count was 20800/μland the C-reactive protein level was 35.6 mg/dl, but computed tomographic (CT) imaging showed no gas in the submandibular space. She received anti-inflammatory treatment after hospitalization, but the symptoms did not improve. We therefore repeated CT imaging and discovered gas in the tissue space around the submental region. Based on the diagnosis of cervical necrotizing fasciitis, we performed emergency surgery, curettage of the lesion, and open surgery. The preoperative plain chest X-ray films the showed no abnormal findings. On the following day after surgery, SpO2 fell to the range of 80 %. A plain chest X-ray film showed shadows over the entire right lung field. The left lung showed signs of pneumonia with diffuse shadows. Chest CT images revealed shadows and accumulations of pleural effusion in both lung fields. The patient was given a diagnosis of a lung injury due to acute respiratory distress syndrome (ARDS) complicated by a severe infection. She received an intravenous drip infusion of sivelestat sodium (product name: Elaspol Ⓡ ) at a dose of 200 mg/day for 7 days. Pneumonia started to improve on the day afterstarting treatment.Japanese Society of Oral and Maxillofacial Surgeons, 2010年10月, 日本口腔外科学会雑誌, 56(10) (10), 581 - 585, 日本語
Our findings suggest that patients with severe infection should receive systemic management, bearing in mind potential complications of ARDS. - (公社)日本口腔外科学会, 2010年10月, 日本口腔外科学会雑誌, 56(10) (10), 568 - 576, 日本語
- (公社)日本口腔外科学会, 2010年09月, 日本口腔外科学会雑誌, 56(Suppl.) (Suppl.), 97 - 97, 日本語NBI、ルゴール染色の併用により、早期に発見し得た舌表在癌の検討
- (一社)日本障害者歯科学会, 2010年09月, 障害者歯科, 31(3) (3), 558 - 558, 日本語
- 2010年08月, JOURNAL OF DENTAL RESEARCH, 89(8) (8), 854 - 859, 英語[査読有り]研究論文（学術雑誌）
- 2010年06月, TISSUE ENGINEERING PART C-METHODS, 16(3) (3), 347 - 353, 英語[査読有り]研究論文（学術雑誌）
- (NPO)日本口腔科学会, 2010年03月, 日本口腔科学会雑誌, 59(2) (2), 99 - 99, 日本語
- (一社)日本障害者歯科学会, 2009年09月, 障害者歯科, 30(3) (3), 221 - 221, 日本語
- 2009年02月, JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 91B(2) (2), 264 - 270, 英語[査読有り]研究論文（学術雑誌）
- Hypertrophic nonunion usually results from insufficient fracture stabilization. Therefore, most hypertrophic nonunions simply require the stabilization of the nonunion site. However, the reasons why union occurs without treating the nonunion site directly is not well understood biologically. In this study, we hypothesized that the intervening tissue at the hypertrophic nonunion site (nonunion tissue) could serve as a reservoir of mesenchymal progenitor cells and investigated whether the cells derived from nonunion tissue had the capacity for multilineage mesenchymal differentiation. After nonunion tissue was obtained, it was cut into strips and cultured. Homogenous fibroblastic adherent cells were obtained. Flow cytometry revealed that the adherent cells were consistently positive for mesenchymal stem cell related markers CD13, CD29, CD44, CD90, CD105, CD166, and negative for the hematopoietic markers CD14, CD34, CD45, and CD133, similar to control bone marrow stromal cells. In the presence of lineage-specific induction factors, the adherent cells differentiated in vitro into osteogenic, chondrogenic, and adipogenic cells. These results demonstrated for the first time that hypertrophic nonunion tissue contains multilineage mesenchymal progenitor cells. This suggests that hypertrophic nonunion tissue plays an important role during the healing process of hypertrophic nonunion by serving as a reservoir of mesenchymal cells that are capable of transforming into cartilage and bone forming cells.2009年02月, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 27(2) (2), 208 - 215, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2008年, Kobe Journal of Medical Sciences, 54(3) (3), 163 - 168.Two cases of masticator space abscess initially diagnosed as temporomandibular joint disorder.
- (公社)日本口腔外科学会, 2007年12月, 日本口腔外科学会雑誌, 53(12) (12), 758 - 758, 日本語舌および頸部に発生し嚥下障害をきたした巨大な血管奇形の1例
- (公社)日本口腔インプラント学会, 2007年03月, 日本口腔インプラント学会誌, 20(1) (1), 139 - 140, 日本語当科における高度先進医療「インプラント義歯」の臨床統計的検討
- (公社)日本口腔外科学会, 2006年09月, 日本口腔外科学会雑誌, 52(Suppl.) (Suppl.), 76 - 76, 日本語下顎骨転移性腫瘍の5例
- 2024年01月, Clinical Oral Investigations, 28(1) (1)書評論文,書評,文献紹介等
- 2023年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 41st口腔扁平上皮癌に対するニボルマブの治療効果と好中球数・リンパ球数比に関する研究
- 2023年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 41st手術(切除)療法ワーキンググループ報告
- 2022年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 40th口腔癌の入院加療中に介護保険申請が必要となった患者の検討
- 2022年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 40th多施設後ろ向き試験による舌癌における手術断端近接症例の検討-Japan Oral Oncology Group(JOOG) study-
- 2021年, 電子情報通信学会技術研究報告(Web), 120(431(MI2020 47-97)) (431(MI2020 47-97))正規化相互相関とDice係数を用いた術前頭部CT画像および病理画像の対応付け手法
- 2021年, 電子情報通信学会技術研究報告(Web), 120(431(MI2020 47-97)) (431(MI2020 47-97))異常検知による顎骨骨髄炎発症範囲の自動推定
- 2021年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 39th炭酸ガス経皮投与による腫瘍免疫抑制の改善効果
- 2021年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 39th病理組織学的にリンパ上皮癌と診断された舌癌の1例
- 2021年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 39th口腔癌における非制御症例の考察と今後の展望~大学病院での検討~
- 2020年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 38th口腔外科手術周術期における抗血栓療法患者に対するヘパリンブリッジの有効性に関する多施設共同後ろ向き観察研究
- 2020年, 日本外科感染症学会雑誌(Web), 17(5) (5)大腸癌術後SSIに対する周術期口腔ケアの予防効果に関する多施設共同研究
- (一社)日本有病者歯科医療学会, 2019年12月, 有病者歯科医療, 28(6) (6), 471 - 471, 日本語抗凝固薬内服患者における下顎智歯抜去後の後出血発症に関する多施設共同後ろ向き観察研究
- (一社)日本口腔腫瘍学会, 2019年09月, 日本口腔腫瘍学会誌, 31(3) (3), 111 - 116, 日本語「口腔がん治療における周術期口腔機能管理とは?」 口腔・中咽頭がん放射線治療時の口腔粘膜炎と口腔カンジダ症のリスク因子 多施設共同研究による326例の解析結果
- (一社)日本口腔ケア学会, 2019年04月, 日本口腔ケア学会雑誌, 13(3) (3), 189 - 189, 日本語口腔・中咽頭がん放射線治療時の口腔粘膜炎予防法について 歯科衛生士の立場からの提言
- (一社)日本歯科薬物療法学会, 2019年03月, 歯科薬物療法, 38(2) (2), 176 - 176, 日本語抗凝固薬内服患者における下顎智歯抜去後の後出血発症に関する多施設共同後ろ向き観察研究
- (一社)日本歯科薬物療法学会, 2019年03月, 歯科薬物療法, 38(2) (2), 176 - 176, 日本語抗凝固薬内服患者における下顎智歯抜去後の後出血発症に関する多施設共同後ろ向き観察研究
- 2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th口腔扁平上皮癌における人工多能性幹細胞関連因子の発現について
- 2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th口腔扁平上皮癌を有する高齢者に対するG8スクリーニングツールの臨床的意義
- 2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 148, 日本語当科におけるメトトレキサート関連リンパ増殖性疾患の3例
- 2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 122, 日本語当科におけるUnusualな再発症例について
- 2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 120, 日本語炭酸ガスを使用した効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果
- 2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 112, 日本語再建を伴う口腔癌の周術期静脈血栓塞栓症について
- 2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 156, 日本語口腔癌におけるPET‐MRI~第二報~
- (一社)日本有病者歯科医療学会, 2018年12月, 有病者歯科医療, 27(6) (6), 451 - 451, 日本語「抗血栓療法患者の抜歯ガイドライン」改訂に向けて2015年度版の自己評価 抗凝固療法(ワルファリン投与)患者の抜歯後出血リスク因子について 多施設共同研究の結果から
- PURPOSE: Few studies exist that focus on the details of perioperative antibiotic administration for surgery to treat medication-related osteonecrosis of the jaw (MRONJ). The regime and duration of perioperative antibiotics applied in published studies were reviewed to clarify appropriate perioperative antibiotic use in MRONJ surgery. METHODS: A literature search was conducted using the MEDLINE database via PubMed. RESULTS: The search resulted in 453 hits on PubMed. After reading the downloaded full-text articles, 17 articles met the inclusion and exclusion criteria. The most common perioperative antibiotic used for MRONJ surgery was a combination of penicillin-based antibiotics and β-lactamase inhibitor (52.9%), and the second most common regime was penicillin-based antibiotics with metronidazole (17.6%). The duration of administration was 2 weeks postoperatively in nine studies, whereas four studies applied long-term administration (2-6 weeks postoperatively). CONCLUSIONS: Oral and maxillofacial surgeons mostly prefer penicillin-based antibiotics plus β-lactamase inhibitor or metronidazole for MRONJ surgery. The duration of administration of these medications may be based on empirical experience.2018年12月, Oral and maxillofacial surgery, 22(4) (4), 369 - 378, 英語, 国際誌[査読有り]
- (公社)日本顎顔面インプラント学会, 2018年11月, Japanese Journal of Maxillo Facial Implants, 17(3) (3), 224 - 224, 日本語当科におけるインプラント埋入症例と喪失リスク因子に関する後ろ向き観察研究
- (一社)日本癌治療学会, 2018年10月, 日本癌治療学会学術集会抄録集, 56回, P1 - 1, 英語癌患者の口腔機能管理の基準に関する多施設共同後ろ向き観察研究
- (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 89 - 89, 日本語医科歯科連携 がん手術時の周術期口腔機能管理の有効性に関する多施設共同研究
- (一社)日本骨代謝学会, 2018年07月, 日本骨代謝学会学術集会プログラム抄録集, 36回, 107 - 107, 日本語骨代謝学と口腔外科学のクロスオーバーからクロスイノベーションへ 薬剤関連顎骨壊死の治療と予防(口腔外科の立場から)
- (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 110 - 110, 日本語口腔癌術後に予定外に再度の全身麻酔による手術を要した症例の検討
- (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 89 - 89, 日本語医科歯科連携 抜歯と薬剤関連性顎骨壊死に関する多施設共同後ろ向き研究 注射BP製剤とデノスマブにおける抜歯前休薬の有無について
- (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 103 - 103, 日本語頸部リンパ節転移陽性口腔扁平上皮癌の予後因子におけるlymph node ratioの有用性に関する検討
- (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 112 - 112, 日本語当科における口腔癌への緩和照射に関する臨床的検討
- (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 113 - 113, 日本語術後に気道閉塞を生じた口腔癌患者の3例
- (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 117 - 117, 日本語頸部郭清を伴う口腔癌術後合併症に関する臨床的検討
- (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 119 - 119, 日本語口腔癌原発巣手術における術中迅速診断の臨床的検討
- (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 121 - 121, 日本語膠原病を有する口腔癌症例の臨床的検討
- (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 131 - 132, 日本語下顎智歯抜歯後の術後出血に関するリスク因子についての検討
- (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 171 - 172, 日本語がん治療中の口腔有害事象発症リスクに関する後ろ向き観察研究
- (一社)兵庫県歯科医師会, 2018年05月, 歯界月報, (802) (802), 84 - 84, 日本語高齢者疾患と歯科治療 注意すべき薬とその対応法
- (NPO)日本顎変形症学会, 2018年05月, 日本顎変形症学会雑誌, 28(2) (2), 181 - 181, 日本語金属アレルギーを伴う骨格性下顎前突患者に対し外科的矯正治療を行った1例
- (一社)日本口腔ケア学会, 2018年04月, 日本口腔ケア学会雑誌, 12(3) (3), 134 - 134, 日本語がん口腔管理ガイドライン 癌患者の口腔機能管理の基準に関する多施設共同後ろ向き観察研究
- (一社)日本口腔ケア学会, 2018年04月, 日本口腔ケア学会雑誌, 12(3) (3), 196 - 196, 日本語肺癌術後肺炎予防における周術期口腔機能管理の有用性 傾向スコアマッチング法を用いた解析
- (一社)兵庫県歯科医師会, 2018年04月, 歯界月報, (801) (801), 52 - 60, 日本語抜歯における下唇知覚鈍麻と上顎洞穿孔のリスクとその対応記事・総説・解説・論説等（学術雑誌）
- 2018年, 日本口腔科学会雑誌(Web), 67(2) (2)下顎智歯抜歯後の術後出血に関するリスク因子についての検討
- 2018年, 日本口腔科学会雑誌(Web), 67(2) (2)がん手術時の周術期口腔機能管理の有効性に関する多施設共同研究
- 2018年, 日本口腔科学会雑誌(Web), 67(2) (2)抜歯と薬剤関連性顎骨壊死に関する多施設共同後ろ向き研究~注射BP製剤とデノスマブにおける抜歯前休薬の有無について~
- 2018年, 日本口腔科学会雑誌(Web), 67(2) (2), 117(J‐STAGE), 日本語頸部郭清を伴う口腔癌術後合併症に関する臨床的検討
- 2018年, 日本口腔科学会雑誌(Web), 67(2) (2), 103(J‐STAGE), 日本語頸部リンパ節転移陽性口腔扁平上皮癌の予後因子におけるlymph node ratioの有用性に関する検討
- 2018年, 日本口腔科学会雑誌(Web), 67(2) (2), 121(J‐STAGE), 日本語膠原病を有する口腔癌症例の臨床的検討
- 2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 161, 日本語放射線性下顎骨壊死の診断におけるfollow up PET‐CTの有用性
- 2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 181, 日本語皮弁再建後の再発舌癌に対して救済手術を施行した2例
- 2018年, 日本口腔科学会雑誌(Web), 67(2) (2), 112(J‐STAGE), 日本語当科における口腔癌への緩和照射に関する臨床的検討
- 2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 160, 日本語超音波断層法による口腔癌頸部リンパ節転移の検討
- 2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 164, 日本語舌扁平上皮癌の原発巣再発例の検討
- 2018年, 日本口腔科学会雑誌(Web), 67(2) (2), 113(J‐STAGE), 日本語術後に気道閉塞を生じた口腔癌患者の3例
- 2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 151, 日本語口腔癌術後病理minor risk症例の臨床的検討
- 2018年, 日本口腔科学会雑誌(Web), 67(2) (2), 110(J‐STAGE), 日本語口腔癌術後に予定外に再度の全身麻酔による手術を要した症例の検討
- 2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 149, 日本語口腔癌再建術後Recipient‐site infectionの定義に関する文献レビュー
- 2018年, 日本口腔科学会雑誌(Web), 67(2) (2), 119(J‐STAGE), 日本語口腔癌原発巣手術における術中迅速診断の臨床的検討
- (一社)日本口腔腫瘍学会, 2017年12月, 日本口腔腫瘍学会誌, 29(4) (4), 198 - 205, 日本語口腔がん手術の適応を考える 頸部リンパ節の状態から考えた手術の適応と補助療法記事・総説・解説・論説等（学術雑誌）
- (公社)日本顎顔面インプラント学会, 2017年11月, Japanese Journal of Maxillo Facial Implants, 16(3) (3), 233 - 233, 日本語移植腓骨へ埋入したインプラント体の周囲炎に対し炭酸ガスレーザーを適用した1例
- (一社)日本癌治療学会, 2017年10月, 日本癌治療学会学術集会(Web), 55th, ROMBUNNO.PS‐2 (WEB ONLY) - 2, 日本語口腔ケアの食道癌術後肺炎予防効果に関する多施設共同研究:傾向スコア法による解析
- (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66(2) (2), 113 - 113, 日本語当科における予防的頸部郭清術に関する後ろ向き検討
- (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66(2) (2), 114 - 114, 日本語口腔扁平上皮癌における術後早期(1年以内)の予後不良例に関する臨床的検討
- (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66(2) (2), 114 - 114, 日本語口腔癌手術における嚥下改善手術に関する臨床的検討
- (一社)日本口腔ケア学会, 2017年04月22日, 日本口腔ケア学会雑誌, 11(3) (3), 122 - 122, 日本語食道がん術後肺炎に対する口腔ケアの予防効果~口腔ケア学会共同研究委員会による多施設共同研究の提案~
- (一社)日本口腔ケア学会, 2017年04月, 日本口腔ケア学会雑誌, 11(3) (3), 121 - 121, 日本語頭頸部癌化学放射線治療患者における口腔内細菌数と口腔粘膜水分量の解析
- (一社)日本口腔ケア学会, 2017年04月, 日本口腔ケア学会雑誌, 11(3) (3), 170 - 170, 日本語肺癌術後肺合併症と周術期口腔機能管理の有用性
- 2017年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 35th口腔癌放射線治療における新規併用療法の開発
- 2017年, 日本口腔科学会学術集会プログラム・抄録集, 71st, 181, 日本語当科における予防的頸部郭清術に関する後ろ向き検討
- 2017年, 日本口腔科学会学術集会プログラム・抄録集, 71st, 183, 日本語口腔扁平上皮癌における術後早期(1年以内)の予後不良例に関する臨床的検討
- 2017年, 日本口腔科学会学術集会プログラム・抄録集, 71st, 183, 日本語口腔癌手術における嚥下改善手術に関する臨床的検討
- Risk factors associated with oroantral perforation during surgical removal of maxillary third molar teeth.PURPOSE: The relationship between radiographic findings and the occurrence of oroantral perforation is controversial. Few studies have quantitatively analyzed the risk factors contributing to oroantral perforation, and no study has reported multivariate analysis of the relationship(s) between these various factors. This retrospective study aims to fill this void. METHODS: Various risk factors for oroantral perforation during maxillary third molar extraction were investigated by univariate and multivariate analysis. The proximity of the roots to the maxillary sinus floor (root-sinus [RS] classification) was assessed using panoramic radiography and classified as types 1-5. The relationship between the maxillary second and third molars was classified according to a modified version of the Archer classification. The relative depth of the maxillary third molar in the bone was classified as class A-C, and its angulation relative to the long axis of the second molar was also recorded. RESULTS: Performance of an incision (OR 5.16), mesioangular tooth angulation (OR 6.05), and type 3 RS classification (i.e., significant superimposition of the roots of all posterior maxillary teeth with the sinus floor; OR 10.18) were all identified as risk factors with significant association to an outcome of oroantral perforation. CONCLUSION: To our knowledge, this is the first multivariate analysis of the risk factors for oroantral perforation during surgical extraction of the maxillary third molar. This RS classification may offer a new predictive parameter for estimating the risk of oroantral perforation.2016年12月, Oral and maxillofacial surgery, 20(4) (4), 369 - 375, 英語, 国際誌
- (公社)日本顎顔面インプラント学会, 2016年11月, Japanese Journal of Maxillo Facial Implants, 15(3) (3), 207 - 207, 日本語内視鏡支援下で上顎洞迷入インプラントの摘出後に骨造成術を行った1例
- (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65(2) (2), 127 - 128, 日本語当科におけるFibro-osseous lesionsの臨床的検討
- (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65(2) (2), 214 - 214, 日本語遺伝子解析により確定診断を得た頬粘膜MALTリンパ腫の1例
- (一社)日本頭頸部癌学会, 2016年05月, 頭頸部癌, 42(2) (2), 170 - 170, 日本語T1-2N0M0舌癌に予防郭清を行うことの是非に関する多施設共同研究(JOOG RA1403)
- 2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th口腔扁平上皮癌における外的刺激受容体(TRPVチャネル)の発現亢進
- 2016年, 日本口腔科学会雑誌(Web), 65(4) (4)食道がん術後肺炎予防に対する周術期口腔機能管理の有効性 -多施設共同後ろ向き研究による検証-
- 2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 163, 日本語食道がん術後肺炎予防に対する周術期口腔機能管理の有効性に関する多施設共同後ろ向き研究
- 2016年, 日本口腔科学会学術集会プログラム・抄録集, 70th, 159, 日本語当科におけるFibro‐osseous lesionsの臨床的検討
- 2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 231, 日本語術前18F‐FDG PET/CT撮影での口腔癌原発巣における定量評価の有用性
- 2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 234, 日本語口腔扁平上皮癌被膜外浸潤症例の臨床病理学的検討
- 2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 221, 日本語口腔扁平上皮癌患者の遠位レベル(Level4,5)への頸部リンパ節転移が予後に与える影響
- 2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 208, 日本語局所的炭酸ガス投与による皮弁壊死抑制効果
- 2016年, 日本口腔科学会学術集会プログラム・抄録集, 70th, 286, 日本語遺伝子解析により確定診断を得た頬粘膜MALTリンパ腫の1例
- 2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 208, 日本語移植腓骨と下顎骨の癒合における骨膜温存の重要性
- 2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd口腔扁平上皮癌臨床検体におけるミトコンドリア量について
- 2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 245, 日本語口腔癌術後再発ハイリスク因子を規定する被膜外浸潤の進展度分類
- 2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 295, 日本語当科における頸部郭清術術後の頸部ドレーンに関する臨床的検討
- 2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 237, 日本語当科における放射線性顎骨壊死に関する臨床的検討
- 2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 301, 日本語当科における口腔扁平上皮癌遠隔転移例の臨床的検討とリスク因子について
- 2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 188, 日本語口腔癌原発巣におけるDual‐time‐point FDG PETの有用性に関する検討
- (株)第一歯科出版, 2015年01月, 歯科医療, 29(1号) (1号), 4 - 10, 日本語【全身疾患と抜歯-最新の知識による適切な対応-】 全身疾患を有する患者の抜歯の際に注意すべき基本的事項[招待有り]記事・総説・解説・論説等（学術雑誌）
- 2015年01月, 歯科医療, 29(1号) (1号), 45 - 52, 日本語【全身疾患と抜歯-最新の知識による適切な対応-】 抗凝固薬・抗血小板薬投与患者の抜歯[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2014年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 32nd, 172, 日本語口腔癌cN1症例に対する頸部郭清術の郭清範囲についての検討
- 2014年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 32nd, 219, 日本語40歳未満に発生した舌扁平上皮癌21例の検討
- 2013年, 大和証券ヘルス財団研究業績集, 36, 104 - 107, 日本語ビスホスホネート関連顎骨壊死(BRONJ)に対する新規治療法の開発記事・総説・解説・論説等（その他）
- (NPO)日本口腔科学会, 2011年07月, 日本口腔科学会雑誌, 60(3) (3), 232 - 239, 日本語
- (公社)日本顎顔面インプラント学会, 2008年11月, Japanese Journal of Maxillo Facial Implants, 7(2) (2), 171 - 171, 日本語骨折血腫細胞の多分化能についての検討と低出力超音波パルス(LIPUS)による効果について
- (公社)日本整形外科学会, 2008年08月, 日本整形外科学会雑誌, 82(8) (8), S1195 - S1195, 日本語ヒト新鮮骨折において、低出力超音波パルス(LIPUS)は骨折血腫細胞の骨分化を促進する
- (公社)日本整形外科学会, 2008年08月, 日本整形外科学会雑誌, 82(8) (8), S1259 - S1259, 日本語ヒトの骨折治癒過程に携わる骨折血腫細胞には骨形成蛋白が発現している
- (公社)日本口腔インプラント学会, 2008年03月, 日本口腔インプラント学会誌, 21(1) (1), 199 - 199, 日本語β-リン酸三カルシウム(β-TCP)内への骨髄幹細胞(BMSC)導入方法と骨形成能の検討
- 2007年09月, JOURNAL OF BONE AND MINERAL RESEARCH, 22, S242 - S242, 英語Nondestructive evaluation of cell numbers in bone marrow stromal cells biodegradable scaffold composites using ultrasound.研究発表ペーパー・要旨（国際会議）
- クインテッセンス株式会社．, 2020年周術期等口腔機能管理の実際がよくわかる本．人工関節手術と口腔管理．
- その他, 永末書店, 2018年, 日本語日常の口腔外科 改訂版 スマートな病診連携のために / 5画像検査の読影学術書
- その他, Oxford University Press, 2018年, 英語Oral and Craniofacial Diseases and Disorders / Capter 2: Complications Following Radiation Therapy for Head and Neck Malignancy学術書
- その他, 医歯薬出版, 2018年, 日本語Clinical Questionでわかるエビデンスに基づいた周術期口腔機能管理 / CHAPTER-4 周術期口腔機能管理に関するClinical Question Q16 骨吸収抑制薬投与患者の抜歯時に休薬は必要でしょうか?学術書
- その他, 歯科医療, 2015年01月, 日本語全身疾患を有する患者の抜歯の際に注意すべき基本的事項 / 【全身疾患と抜歯-最新の知識による適切な対応-】学術書
- その他, －, 2015年01月, 日本語抗凝固薬・抗血小板薬投与患者の抜歯 / 【全身疾患と抜歯-最新の知識による適切な対応-】学術書
- その他, 第一歯科出版, 2014年, 日本語新こんな患者さんが歯科に来たときは？全身疾患・口腔外科疾患に対する診療マニュアル / 抗血小板薬服用患者への対応一般書・啓蒙書
- その他, 第一歯科出版, 2014年, 日本語新こんな患者さんが歯科に来たときは？全身疾患・口腔外科疾患に対する診療マニュアル / 抗凝固薬服用患者への対応一般書・啓蒙書
- その他, 第一歯科出版, 2014年, 日本語新こんな患者さんが歯科に来たときは？全身疾患・口腔外科疾患に対する診療マニュアル / 血小板減少患者への対応一般書・啓蒙書
- The 4th Asia Pacific Region Congress of the International Association for Dental Research, 2019年11月The observational study of the risk factors associate with implant failure in our institution.
- 6th Asian Academy congress for TMJ, 2019年06月A multi-center retrospective study of mandibular fractures: Do occlusal support and the mandibular third molar affect mandibular condylar fractures?
- 6th Asian Society of Head & Neck Oncology, 2019年03月A retrospective study of risk factors associated with distant metastasis in patients with oral squamous cell carcinoma
- 第37回日本口腔腫瘍学会総会, 2019年01月炭酸ガスを使用した効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果[招待有り]
- 第37回日本口腔腫瘍学会総会, 2019年01月口腔癌頸部リンパ節転移の様相と術後補助療法に関する多施設共同研究[招待有り]
- 第72回日本口腔科学会学術集会, 2018年05月抜歯と薬剤関連性顎骨壊死に関する多施設共同後ろ向き研究 ～注射BP製剤とデノスマブにおける抜歯前休薬の有無について～
- 第22回口腔顔面神経機能大会, 2018年03月下顎智歯抜歯後の下唇知覚鈍麻と術前のパノラマX線および多断面再構成CT画像所見との関係
- 第62回日本口腔外科学会総会・学術大会, 2017年10月, 日本語, 京都, 国内会議下顎骨壊死における下歯槽神経障害の臨床病理学的検討口頭発表（一般）
- 第41回日本頭頸部癌学会（京都）, 2017年06月, 日本語, 日本頭頸部癌学会, 京都, 国内会議神経症状を伴った下顎放射線性顎骨壊死における下歯槽神経の病理組織学的研究．口頭発表（一般）
- 23nd International Conference on Oral and Maxillofacial Surgery（Hong Kong）, 2017年03月, 日本語, International Conference on Oral and Maxillofacial Surgery, Hong Kong, 海外, 国内会議4DCT EVALUATION OF CONDYLAR MOVEMEN IN PATIENTS UNDERWENT MANDIBULAR RECONSTRUCTION．口頭発表（一般）
- 第35回口腔腫瘍学会（福岡）, 2017年01月, 日本語, 口腔腫瘍学会, 福岡, 国内会議口腔扁平上皮癌では外的刺激受容体（TRPVチャネル）の発現が亢進する．口頭発表（一般）
- 第20回日本顎顔面インプラント学会, 2016年12月, 日本語, 日本顎顔面インプラント学会, 東京, 国内会議内視鏡支援下で上顎洞迷入インプラントの摘出後に骨造成術を行った1例ポスター発表
- 第20回日本顎顔面インプラント学会, 2016年12月, 日本語, 日本顎顔面インプラント学会, 東京, 国内会議当科におけるインプラント埋入症例と喪失リスクに関する臨床的検討ポスター発表
- 第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議腓骨皮弁による下顎再建におけるミニプレートと再建用プレートの比較口頭発表（一般）
- 第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議放射線性顎骨壊死発症リスク因子の検討ー多施設共同後ろ向き研究ー口頭発表（一般）
- 第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議当科における舌癌・口底癌手術症例の再建方法に関する検討ポスター発表
- 第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議当科における心臓血管外科開胸手術患者に対する周術期口腔機能管理の臨床的検討口頭発表（一般）
- 第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議当科における口腔癌患者の口腔内細菌数の変化とSSIについて口頭発表（一般）
- 第61回公益社団法人日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 公益社団法人日本口腔外科学会総会・学術大会, 千葉市, 国内会議舌癌切除後の前腕皮弁再建における 切除検体サイズと皮弁サイズの 相関と機能の検討口頭発表（一般）
- 第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議舌癌切除後の前腕皮弁再建における切除検体サイズと皮弁サイズの僧冠と機能の検討口頭発表（一般）
- 第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議上顎洞隔壁の形態に関する解剖学的検討ポスター発表
- 第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議口腔癌放射線治療における有効な新規併用療法の探索ポスター発表
- 第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議口腔癌術後リンパ浮腫に関するCT解析口頭発表（一般）
- 第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議口腔外科手術と薬剤関連性顎骨壊死に関する多施設共同後ろ向き研究口頭発表（一般）
- 第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議局所的炭酸ガス投与による皮弁壊死抑制効果ポスター発表
- 第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議下顎枝垂直骨切り術後の骨癒合に対する低出力超音波パルス(LIPUS)の効果ポスター発表
- 第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議遠位レベル(Level IV,V)への頸部リンパ節転移を生じた口腔扁平上皮癌患者の予後に関する後ろ向き観察研究口頭発表（一般）
- 第12回日本口腔ケア協会学術大会, 2016年11月, 日本語, 日本口腔ケア協会, 長崎, 国内会議シンポジウム1:「抜くべきか 抜かざるべきか それが問題だ」骨吸収抑制剤患者における抜歯前休薬と術中処置について口頭発表（一般）
- The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議Development of the new treatment of OSCC by local application of transcutaneous carbon dioxideポスター発表
- The 23th Congress of EACMFS, 2016年09月, 英語, Congress of EACMFS, London, イギリス, 国際会議Determination of resection margins by using a combination of CT, MRI, PET, and 3D model in osteoradionecrosis of the jaw口頭発表（一般）
- The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議Determination of resection margins by using a combination of CT, MRI, PET, and 3D model in osteoradionecrosis of the jawポスター発表
- The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議Changes of cell junctions induced by EGFR inhibition in oral squamous cell carcinomasポスター発表
- The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議A clinical study of injured patients treated with dental implantsポスター発表
- The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS),, 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議A clinical study of 12 implants resulting in implant removalポスター発表
- 第32回兵庫県歯科医学大会, 2016年07月, 日本語, 兵庫県歯科医師会, 神戸, 国内会議当科における心臓血管外科周術期の口腔機能管理に関する実態と今後の課題口頭発表（一般）
- 第32回兵庫県歯科医学大会, 2016年07月, 日本語, 兵庫県歯科医師会, 神戸, 国内会議上顎智歯抜歯のおける上顎洞穿孔リスクとその対応について口頭発表（一般）
- 第16回日本外傷歯学会総会・学術大会, 2016年07月, 日本語, 日本外傷歯学会, 神戸, 国内会議下顎骨骨折の治療を行ったLennox-Gastaut症候群患児の1例口頭発表（一般）
- 第40回日本頭頸部癌学会総会・学術大会, 2016年06月, 日本語, 日本頭頸部癌学会, 埼玉, 国内会議歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価口頭発表（一般）
- 第40回日本頭頸部癌学会, 2016年06月, 日本語, 日本頭頸部癌学会, さいたま市, 国内会議歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価口頭発表（一般）
- 第40回日本頭頸部癌学会総会・学術大会, 2016年06月, 日本語, 日本頭頸部癌学会, 埼玉, 国内会議口腔癌病理学的再発高リスク例に対する術後補助療法の検討口頭発表（一般）
- 第40回日本頭頸部癌学会総会・学術大会, 2016年06月, 日本語, 日本頭頸部癌学会, 埼玉, 国内会議下顎歯肉がんのT分類（多施設共同後ろ向き研究 JOOG RA-1401）口頭発表（一般）
- 第26回日本顎変形症学会総会・学術大会, 2016年06月, 日本語, 日本顎変形症学会, 東京, 国内会議下顎枝垂直骨切り術後の骨癒合に対する低出力超音波パルス(LIPUS)の効果ポスター発表
- 第26回日本顎変形症学会総会・学術大会, 2016年06月, 日本語, 日本顎変形症学会, 東京, 国内会議下顎骨偏位と乳様突起体積および頭位に関する検討ポスター発表
- 第40回日本頭頸部癌学会総会・学術大会, 2016年06月, 日本語, 日本頭頸部癌学会, 埼玉, 国内会議T2N0M0舌癌に予防郭清を行うことの是非に関する多施設共同研究（JOOG RA1403）口頭発表（一般）
- 第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議当科における埋伏智歯抜歯後神経系合併症に対する治療法の現状口頭発表（一般）
- 第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議当科におけるFibro-osseous lesionsの臨床的検討口頭発表（一般）
- 第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議遺伝子解析により確定診断を得たMALTリンパ腫の1例口頭発表（一般）
- 第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議腓骨皮弁採取部における一期縫縮と植皮の比較ポスター発表
- 第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議術前18F-FDG PET/CT撮影での口腔癌原発巣における定量評価の有用性ポスター発表
- 第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議口腔扁平上皮癌被膜外浸潤症例の臨床病理学的検討ポスター発表
- 第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議口腔扁平上皮癌患者の遠位レベル（level4,5）への頸部リンパ節転移が予後に与える影響ポスター発表
- 第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会総会・学術大会, 横浜市, 国内会議口腔扁平上皮癌における外的刺激受容体（TRPVチャネル）の発現口頭発表（一般）
- 第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議口腔扁平上皮癌における外的刺激受容体(TRPVチャネル)の発現亢進ポスター発表
- 第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議口腔癌再発高リスク例に対する高用量CDDP併用術後補助化学放射線療法の検討口頭発表（一般）
- 第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議局所的炭酸ガス投与による皮弁壊死抑制効果ポスター発表
- 第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議移植腓骨と下顎骨の癒合における骨膜温存の重要性（ポスター発表）ポスター発表
- 第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会総会・学術大会, 横浜市, 国内会議移植腓骨と下顎骨の癒合における骨膜温存の重要性口頭発表（一般）
- 第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議入院管理下で口腔外科小手術を施行した患者に関する臨床統計口頭発表（一般）
- 第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議超音波断層法による口腔癌頸部リンパ節転移の検討口頭発表（一般）
- 第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議多施設における過去5年の下顎骨骨折症例の検討～下顎智歯と骨折部位の関係口頭発表（一般）
- 第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議三次元実態模型を用いた手術シミュレーションー当科における最近の使用経験口頭発表（一般）
- 第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議抗血栓療法患者における抜歯後出血危険因子についての多施設共同研究－抗凝固療法について－口頭発表（一般）
- 第60回日本口腔外科学会総会．, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議口腔癌術後再発高リスク例に対する放射線化学療法の検討口頭発表（一般）
- 第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議口腔癌原発巣の術前18F-FDG PET/CT撮影に関する検討口頭発表（一般）
- 第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議経皮的炭酸ガス投与による口腔癌上皮間葉移行の抑制効果口頭発表（一般）
- 第60回日本口腔外科学会総会．, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議ロケーター・マグネット付きカスタムバーによるインプラントオーバーデンチャー関連合併症口頭発表（一般）
- 22nd International conference on oral and maxilofacial surgery,, 2015年10月, 英語, メルボルン, オーストラリア, 国際会議Observation of Mastication in Patients Underwent Mandibular Reconstruction by 4D-CT with 320 Detector-Row Scanning : A Preliminary Report,口頭発表（一般）
- 22nd International conference on oral and maxilofacial surgery,, 2015年10月, 英語, メルボルン, オーストラリア, 国際会議Incidence of venousthromboembolism after oral surgery with simultaneous reconstruction,口頭発表（一般）
- 22nd International conference on oral and maxilofacial surgery,, 2015年10月, 英語, メルボルン, オーストラリア, 国際会議Evaluation of progression level of extracapsular spread for cervical lymph node metastasis of oral squamous cell carcinoma: a multicenter retrospective study.口頭発表（一般）
- 第60回日本口腔外科学会総会．, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議Evaluating the changes in the amount of bone augmentation after sinus lift using panoramic radiography: Comparison evaluations based on CT images．口頭発表（一般）
- 第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議A novel strategy aimed at apoptosis via the mitochondrial pathway and improving hypoxia in oral squamous cell carcinoma.．口頭発表（一般）
- 第12回日本口腔ケア学会総会・学術大会．, 2015年06月, 日本語, 日本口腔ケア学会, 山口, 国内会議当院における周術期口腔機能管理に関する実態調査と今後の課題口頭発表（一般）
- 第25回日本顎変形症学会総会．, 2015年06月, 日本語, 日本顎変形症学会, 東京, 国内会議外科的矯正手術前後における顎関節症状および顎関節MRI画像の変化.口頭発表（一般）
- "The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, 2015年06月, 英語, 神戸, 国内会議Sequential evaluation of bone union of transferred fibula flaps in reconstructed mandibles.口頭発表（一般）
- "The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, 2015年06月, 英語, 神戸, 国内会議Decreased mitochondrial copy numbers in oral squamous cell carcinoma.口頭発表（一般）
- 第12回日本口腔ケア学会総会・学術大会．, 2015年06月, 日本語, 日本口腔ケア学会, 山口, 国内会議-口頭発表（一般）
- 第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会総会, 奈良, 国内会議予後不良症例を考える－症例検討会－ 口腔・頸部は制御されたが、肺転移を認めた1例口頭発表（一般）
- 第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議当科における頸部郭清術術後の頸部ドレーンに関する臨床的検討口頭発表（一般）
- 第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議当科における放射線性顎骨壊死に関する臨床的検討口頭発表（一般）
- 第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議当科における口腔扁平上皮癌遠隔転移例の臨床的検討とリスク因子について口頭発表（一般）
- 第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議口腔扁平上皮癌臨床検体におけるミトコンドリア量についてポスター発表
- 第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議口腔癌術後再発ハイリスク因子を規定する被膜外浸潤の伸展度分類口頭発表（一般）
- 第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議口腔癌手術症例におけるmodified Glasgow Prognostic Score(mGPS)を用いた長期予後に関する検討ポスター発表
- 第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議口腔癌原発巣におけるDual-time-point FDG PETの有用性口頭発表（一般）
- 第25回日本顎変形症学会総会．, 2015年01月, 日本語, 日本顎変形症学会, 東京, 国内会議下顎枝垂直骨切り術後の近位骨片と下顎頭変化の評価口頭発表（一般）
- 第26回日本口腔科学会近畿地方部会, 2014年12月, 日本語, 日本口腔科学会, 京都, 国内会議放射線治療後の甲状腺機能低下による低ナトリウム血症の1例口頭発表（一般）
- 第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議当科における広範囲顎骨支持型インプラント補綴の臨床統計的検討口頭発表（一般）
- 第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議当科におけるインプラント242例907本埋入に関する臨床的検討口頭発表（一般）
- 第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った症例口頭発表（一般）
- 第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価口頭発表（一般）
- 第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議当科における上顎洞底挙上術後の骨量変化の臨床的検討口頭発表（一般）
- 第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議当科における口腔癌患者の術後せん妄に関する臨床的検討口頭発表（一般）
- 第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議低出力超音波パルスの下顎骨骨折血腫細胞のBMP発現における効果ポスター発表
- 第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議上顎部分切除後の遊離前腕皮弁再建群と非再建群の比較口頭発表（一般）
- 第23回日本口腔感染症学会総会, 2014年10月, 日本語, 日本口腔感染症学会, 伊丹, 国内会議抗RANKLモノクローナル抗体（デノスマブ）に発症した顎骨壊死の1例口頭発表（一般）
- 第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議口腔扁平上皮癌N0症例への予防的頸部郭清の検討：T1-2とT3-4の比較ポスター発表
- 第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議口腔癌手術における輸血療法の現状口頭発表（一般）
- 第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議口腔癌に対する救済手術についての検討口頭発表（一般）
- 第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議局所的炭酸ガス投与による口腔癌新規治療法の開発ポスター発表
- 第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議急速に増大し巨舌を呈した多発性骨髄腫に伴うアミロイドーシスの1例口頭発表（一般）
- 第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議化学放射線療法中の中咽頭癌患者における口腔乾燥の経時的変化口頭発表（一般）
- 第59回日本口腔外科学会総会・学術集会, 2014年10月, 日本語, 日本口腔外科学会, 幕張, 国内会議フェーズラグCT（pl-CTA）による顎骨周囲の脈管の評価口頭発表（一般）
- 第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議フェーズラグCTA（ｐｌ－CTA）による顎動静脈分岐の評価口頭発表（一般）
- 第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議ビスフォスフォネート関連顎骨壊死症例のCT画像における臨床的検討ポスター発表
- 第24回日本j顎変形症学会総会, 2014年06月, 日本語, 日本顎変形症学会, 福岡, 国内会議顎矯正手術における超音波診断法と単純MRI画像を用いた顎動脈の走行位置評価口頭発表（一般）
- 第68回日本口腔科学会学術総会, 2014年05月, 日本語, 日本口腔科学会, 東京, 国内会議口腔癌再建術後の頸部感染評価目的でのCTの有用性口頭発表（一般）
- 第32回日本口腔腫瘍学会, 2014年01月, 日本語, 日本口腔腫瘍学会, 札幌, 国内会議口腔癌cN1症例に対する頸部郭清術の廓清範囲についての検討口頭発表（一般）
- 第32回日本口腔腫瘍学会, 2014年01月, 日本語, 日本口腔腫瘍学会, 札幌, 国内会議40歳未満に発生した舌扁平上皮癌21例の検討口頭発表（一般）
- 第22回口腔感染症学会総会, 2013年11月, 日本語, 口腔感染症学会, 八王子, 国内会議頸部郭清術後に発症した偽膜性腸炎から中毒性巨大結腸症に至った1例口頭発表（一般）
- 第17回顎顔面インプラント学会総会, 2013年11月, 日本語, 顎顔面インプラント学会, 東京, 国内会議当科におけるインプラントの撤去に至った21症例の臨床的検討口頭発表（一般）
- 第17回顎顔面インプラント学会総会, 2013年11月, 日本語, 顎顔面インプラント学会, 東京, 国内会議下顎のスプリットクレスト法において遊離骨片が生じた6例の臨床的検討口頭発表（一般）
- 第17回顎顔面インプラント学会総会, 2013年11月, 日本語, 顎顔面インプラント学会, 東京, 国内会議CT画像における下顎骨舌側にみられる骨孔の観察口頭発表（一般）
- 第33回日本口腔インプラント学会近畿北陸支部学術大会, 2013年10月, 日本語, 日本口腔インプラント学会, 神戸, 国内会議放射線治療を伴う上顎切除後に骨移植を併用したインプラント顎義歯を用いて機能回復を行った1例口頭発表（一般）
- 第58回日本口腔外科学会総会・学術大会, 2013年10月, 日本語, 日本口腔外科学会総会・学術大会, 福岡市, 国内会議舌半側切除後の遊離前腕皮弁再建症例における長期観察結果．口頭発表（一般）
- 第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議抗血栓療法下での抜歯後出血の臨床的検討口頭発表（一般）
- 第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議口腔癌頸部郭清術後の郭清範囲内および境界領域における頸部再発に関する検討口頭発表（一般）
- 第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議口腔癌患者における胃瘻造設に関する検討―術中同時胃瘻造設について-口頭発表（一般）
- 第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議下顎骨骨折血腫由来細胞の骨分化能に対するBP製剤の効果ポスター発表
- 第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議ミトコンドリア経路に関連した口腔癌新規治療法の開発口頭発表（一般）
- 第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議シスプラチン併用化学放射線療法の術後補助療法としての有効性に関する検討口頭発表（一般）
- 第29回兵庫県歯科医学大会総会, 2013年08月, 日本語, 兵庫県歯科医学大会, 神戸, 国内会議下顎枝垂直骨切り術術後における口腔内・口腔外知覚神経障害の経時的変化に関する検討口頭発表（一般）
- 第44回日本口腔外科学会近畿支部学術集会, 2013年06月, 日本語, 日本口腔外科学会, 神戸, 国内会議舌背部に生じた顆粒細胞腫の1例口頭発表（一般）
- 第23回日本顎変形症学会総会, 2013年06月, 日本語, 日本顎変形症学会, 大阪, 国内会議外科的矯正治療により咬合改善を得た上下顎の歯数不調和を伴う下顎骨骨折変形治癒症例ポスター発表
- 第23回日本顎変形症学会総会, 2013年06月, 日本語, 日本顎変形症学会, 大阪, 国内会議53歳下顎側方偏位症例に対し外科的矯正治療を行った1例ポスター発表
- 第67回日本口腔科学会総会, 2013年05月, 日本語, 日本口腔科学会, 宇都宮, 国内会議放射線治療後に照射範囲外から骨移植を行ったインプラント治療の検討口頭発表（一般）
- 第31回日本口腔腫瘍学会総会, 2013年01月, 日本語, 日本口腔腫瘍学会, 東京, 国内会議口腔癌患者への緩和ケアチームの介入についての臨床的検討口頭発表（一般）
- 第57回日本口腔外科学会総会・学術大会, 2012年10月, 日本語, 日本口腔外科学会, 横浜, 国内会議遊離腓骨皮弁移植におけるMR Angiographyと超音波検査による下肢血管解剖の術前評価口頭発表（一般）
- 第11回日本クリニカルパス学会学術集会, 2010年12月, 日本語, 日本クリニカルパス学会, 松山, 国内会議舌部分切除手術パス作成の取り組み口頭発表（一般）
- 第14回日本顎顔面インプラント学会総会, 2010年12月, 日本語, 日本顎顔面インプラント学会, 千葉, 国内会議下顎骨再建に生体吸収性材料HA/PLLA複合体を使用した1例口頭発表（一般）
- 第27回日本障害者歯科学会総会, 2010年10月, 日本語, 日本障害者歯科学会, 東京, 国内会議抗血栓療法患者の歯科処置における止血困難症例の3症例口頭発表（一般）
- 第55回日本口腔外科学会総会, 2010年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議NBI，ルゴール染色の併用により早期に発見し得た舌表在癌の検討．口頭発表（一般）
- 第102回日本病理学会中国四国支部学術集会, 2010年07月, 日本語, 日本病理学会, 米子, 国内会議下顎骨腫瘍口頭発表（一般）
- 第64回日本口腔科学会総会, 2010年06月, 日本語, 日本口腔科学会, 札幌, 国内会議抗凝固薬継続下で歯科観血的処置を行った256例の検討-後出血の頻度と対策について口頭発表（一般）
- 第64回日本口腔科学会総会, 2010年06月, 日本語, 日本口腔科学会, 札幌, 国内会議口腔外科手術時の開放創に対するPGAシートおよびフィブリン糊スプレーの使用経験（第2報） 早期脱落の原因と対処法[招待有り]口頭発表（招待・特別）
- 第64回日本口腔科学会総会, 2010年06月, 日本語, 日本口腔科学会, 札幌, 国内会議下顎知歯抜歯後の下唇知覚鈍麻と術前のパノラマX線および多断面再構成CT画像所見との関係口頭発表（一般）
- 2010年04月, 日本語, 第19回日本有病者歯科医療学会, 神戸, 国内会議抗血栓療法継続下での歯科観血的処置後の出血の現状と対策口頭発表（一般）
- 2010年01月, 日本語, 第28回日本口腔腫瘍学会総会, 東京, 国内会議口底部に発生した神経鞘腫の1例口頭発表（一般）
- 第35回日本骨折治療学会, 2009年07月, 日本語, 日本骨折治療学会, 横浜, 国内会議ヒト新鮮骨折において、低出力超音波パルス（ＬＩPUS)は骨折血腫由来細胞の分化を促進し骨形成に作用するポスター発表
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2023年04月01日 - 2026年03月31日顎骨壊死に対する腐骨分離促進療法の探索
- 日本学術振興会, 科学研究費助成事業, 基盤研究(B), 広島大学, 2022年04月01日 - 2026年03月31日口腔癌遠隔転移に関与する循環腫瘍細胞および循環腫瘍DNAの多施設共同研究
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2022年04月01日 - 2026年03月31日ミトコンドリアの正常化と癌関連線維芽細胞の再教育を目指した新規口腔癌治療法の開発
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2021年04月01日 - 2025年03月31日環境因子による細胞内シグナル増強と腫瘍悪性化についての相関の解明これまでのわれわれの研究では、生体から得られた口腔粘膜組織（舌、歯肉、 粘膜、口底）の癌細胞と正常粘膜細胞を用いてTRPV1-4イオンチャネルの発現が癌と正常組織でどのように特徴付けられるのかを 証してきた。 （real time PCR法および、免疫組織化学染色法により、①TRPV1,2,3,4全てにおいて、ヒト口腔正常粘膜（舌、歯肉、 粘膜、口底）での発現を確認。②口腔扁平上皮癌と口腔正常粘膜におけるTRPV1,2,3,4の発現量は、扁平上皮癌の方が有意に 増加。③TRPV1,2,3,4全てにおいて、ヒト口腔正常粘膜で‘飲酒あり’群の方が、‘飲酒なし’群よりも有意に増加。④TRPV2,3,4において、ヒト口腔正常粘膜で‘喫煙あり’群の方が、‘喫煙なし’群よりも有意に増加しており、TRPV1も増加傾向。） これまでの研究は、生体から採取した粘膜癌細胞、粘膜正常細胞から採取した組織で行った。培養細胞においても同様な発現が認められるのかを検証中である。生体から採取した組織から細胞を 離しようと試みたが、困難であったため、細胞提供を受けて、培養している。正常粘膜細胞の培地と癌細胞の培地でまずは光刺激でカルシウムイオンチャネルが開くことを確認している。TRPVイオンチャネルの1-4のそれぞれに特有のチャネルを開くアゴニスト （例：カプサイシンやさまざまな温度設定）があるため、おのおので検証してきた。
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 富山大学, 2021年04月01日 - 2024年03月31日口腔扁平上皮癌頸部リンパ節転移被膜外浸潤メカニズムの分子生物学的検討口腔癌の頸部リンパ節転移の被膜外浸潤は術後再発高リスク因子であり、その臨床的意義は大きい。しかしながら、被膜外浸潤の診断にはばらつきがあり、被膜外浸潤症例の中でも予後が別れており、真の術後補助療法の適応例を同定するためには、被膜外浸潤の分類の確立と、その病理組織学的、分子生物学的な裏付けが必要である。われわれが以前に設定した被膜外浸潤の進展度分類と、PD-L1などのマーカーとに関連を明らかにすることで、術後補助療法の適応症例の確立を図る。頸部リンパ節の被膜外浸潤進展症例の症例集積ならびに検体集積を行う予定であったが、被膜外浸潤例の検体収集に問題があり、また、研究代表者の異動に伴い大きな進展ができなかった。被膜外浸潤例のPD-L1の発現について免疫組織学的染色を行っており、被膜外浸潤の進展度分類との関連を検討中である。 また、口腔領域の悪性黒色腫の症例を多施設共同研究の形態で集積し検討を行った。過去21年間69例の口腔粘膜悪性黒色腫症例の2年全生存率、5年全生存率はそれぞれ64.6%、42.5％であった。病期別ではstage IIIの2年全生存率、5年全生存率は85.9％、72.5％、stage IVAでは56.3％、26.0％であり、病期が進展すると有意に予後不良であった。根治的治療を行った群では2年および5年全生存率は74.1％、50.5％であり非根治的治療群に比べて有意に予後が良好であった。手術療法群での全生存に寄与する因子として病期が独立した有意な予後因子として抽出された。
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2019年04月01日 - 2023年03月31日血管・リンパ管新生に着眼した歯性感染症－顎骨骨髄炎移行メカニズム解明と治療法探索
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 兵庫医科大学, 2019年04月01日 - 2022年03月31日唾液腺癌発癌に関わる遺伝子の解析と分子標的薬の探索兵庫医科大学 歯科口腔外科学講座で病理組織学的に診断し、外科的に加療した唾液洗顔における融合遺伝子の検討を行った。遺伝子解析までに至った症例は粘表皮癌3例、腺様嚢胞癌1例、多型腺腫由来癌1例である。いずれの唾液腺癌も過去の報告より有力とされる融合遺伝子の存在が示唆されており、PCR法および sanger法を用いて融合遺伝子の存在を解析した。粘表皮癌ではCRTC1-MAML2またはCRTC3-MAML2の融合が発癌と示唆されているが自検例では2/3にCRTC1-MAML2の発現を確認した。このうち1例より、細胞を試み、培養細胞株化に成功した。さらに粘表皮癌にはこれまで報告されていなかった新たなバイオマーカー候補の存在をRNAシークエンスから見つけ出し、病理組織学的な意義について検討した。 腺様嚢胞癌および多型腺腫由来癌においても融合遺伝子の存在は明らかになりつつあり、これらについても融合遺伝子の関与を検討したが、我々が行なった2例とも融合遺伝子の存在は確認されなかった。これらの結果より唾液腺発癌において融合遺伝子の関与は一部の白血病のように全てではないものの、関与をしていることが明らかになり、融合遺伝子が発癌に関与しているものについては将来、分子標的治療の対象となり得ると考えられ、唾液腺癌に対する遺伝子解析の重要性を示唆しているものと思われた。
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 関西医科大学, 2019年04月01日 - 2022年03月31日薬剤関連顎骨壊死の発症原因解明と発症予防法確立に向けた多施設共同前向き研究ビスホスホネート製剤やデノスマブ製剤などの骨吸収抑制薬は破骨細胞活性を抑制することにより強力な骨吸収抑制作用を示し、骨粗鬆症患者の骨折予防、がんの骨転移や多発性骨髄腫患者の骨関連事象の予防薬として広く用いられている。しかし重大な有害事象の一つとして、薬剤関連顎骨壊死（MRONJ）の発症が問題となっている。MRONJの発症頻度は近年増加しており難治性であるが、高用量の注射骨吸収抑制薬が投与されているがん患者では特に発症率が高い。MRONJの原因として抜歯などの骨への侵襲が考えられてきたが、抜歯そのものではなく抜歯する歯に存在する局所感染がMRONJの原因であり、感染源になる歯は積極的に抜歯をしたほうがいいのではないかという考えも提唱されるようになった。本研究は「感染源になりうる歯を持つ場合、抜歯・保存のいずれがMRONJ発症率を下げることができるか」「抜歯をする場合はどのような手技で抜歯を行えばMRONJ発症率を下げることができるか」「抜歯をしない場合は良好な口腔衛生状態を保つことによりMRONJ発症率を下げることができるか」「抜歯例において 抜歯窩内の細菌感染とMRONJ発症率に関連があるか」「 抜歯をする際の休薬の有無や期間と、抜歯窩周囲歯槽骨の破骨細胞活性に関連はあるか」などを解明することを目的とした多施設共同前向き研究である。
- 学術研究助成基金助成金／基盤研究(C), 2018年04月 - 2022年03月, 研究代表者競争的資金
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 信州大学, 2018年04月01日 - 2021年03月31日口腔癌頸部リンパ節転移被膜外浸潤進展度分類と進展メカニズムの分子細胞生物学的研究本年度は①口腔癌の頸部リンパ節転移の被膜外浸潤症例において、われわれが設定した進展度分類（Yamada S, et al., 2015.）を行い、臨床病理学的因子、予後との相関 を検討し、予後予測因子あるいは術後補助療法適用の指標となり得るかを検討する。②それぞれの進展度分類において、被膜外浸潤最先端部の腫瘍細胞組織をマイクロダイセクション法を用いて選択的に採取し、マイクロアレイを用いて、それぞれの被膜外浸潤進展度の腫瘍細胞の遺伝子発現プロファイルを網羅的に検討し、被膜外浸潤の進展に関与する分子を同定する、ことを計画した。 口腔扁平上皮癌の頸部リンパ節転移があり、被膜外浸潤症例の集積ならびに観察項目のデータ収集を行った。被膜外浸潤症例について、われわれが設定した被膜外浸潤の進展度分類に基づいて分類を行った。また、該当症例について、パラフィンブロックより、薄切標本を作製した。被膜外浸潤および進展度分類に影響する分子について、特に今回は細胞の運動に関連するアクチン束状化タンパクであるactinin-4について免疫組織化学的染色を行い、その発現と臨床病理組織学的因子との関連について検討を行うこととした。しかしながら、リンパ節の薄切標本は比較的大きいことから、免疫組織化学的染色が困難であり、安定的に免疫組織化学的染色を行って評価可能な標本を得ることは困難であった。引き続き、免疫組織化学的染色の染色を安定的にリンパ節標本においても行えるように検討を行い、合わせてマイクロダイセクションの実施を行う。
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 長崎大学, 2017年04月01日 - 2020年03月31日放射線性多発う蝕の発生機序の解明と予防法に関する多施設共同ランダム化比較試験頭頸がんに対する放射線治療（RT）の重篤な晩期有害事象の一つに放射線性顎骨壊死（ORN）がある。照射方法の進歩とともにORNの発症頻度は近年では低くなってきたが、依然として10～20%程度の患者に発症し、患者のQOLを低下させる大きな原因となっている。 実際にRT前と1年後、2年後のパノラマＸ線写真を比較したところ、急速にう蝕が進行する患者が少なからず存在することを確認した。う蝕多発者では唾液腺だけではなく歯に対する照射線量が60Gy以上と多かったが、口腔衛生状態はう蝕が発生しなかった患者と差はなく、さらに上顎あるいは下顎のみに照射された患者では照射された顎にのみう蝕が多発することや、片側の照射例では照射された側にのみう蝕が多発することが明らかとなった。本研究は、1）RT後の多発う蝕の実態を多施設共同後ろ向き観察研究で明らかにすること、2）RT後に歯を含む歯槽部が切除された患者の切除検体を用いてRTによる歯の直接障害の有無や程度について調べること、および3）トレー法によるフッ化物局所応用によりRT後のう蝕多発が予防できるかどうかを多施設共同ランダム化比較試験により検証することを目的とするものである。そこでまずは後ろ向きに調査した。その後ろ向き研究では、口腔がん手術単独例では2年後のう蝕増加数は0.6歯であったのに対して、RT患者では4.9歯と有意に多かった。放射線性う蝕の特徴としては、①歯頸部からの発生が多い、②疼痛などの自覚症状に乏しい、③歯頸部から歯が破折して初めて発見されることも少なくない，④歯の黒変，あるいは歯冠歯質の軟化がみられることもある、⑤歯質の欠損がない、あるいはC2までの状態で歯根膜腔の拡大や根尖病巣を認めるというものであった。そこで実際に頭頸部がんRT患者10例を1年間観察したところ新たなう蝕の発生はみられなかった。
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 関西医科大学, 2016年04月01日 - 2019年03月31日放射線性顎骨壊死の病態と発症リスク因子の解明に関する多施設共同研究2008年～2014年の頭頸部癌放射線治療患者392例の多施設共同研究では、放射線性顎骨壊死（ORN）の発症リスク因子として、Cox回帰分析による多変量解析で原発部位(口腔中咽頭癌)、RT時の根尖病巣（あり）、RT後の抜歯（あり）の3因子が独立した因子として同定された。ORN発症例30例の検討では下顎発症例が多く、発症契機として根尖病巣やRT後の抜歯の他、放射線誘発性う蝕が挙げられた。さらに2015年～2017年の口腔・中咽頭癌放射線治療患者132例では、2014年以前と比べてORN発症率が有意に増加していたが、その理由については不明であり、今後さらに検討したい。
- 学術研究助成基金助成金／若手研究(B), 2015年04月 - 2018年03月, 研究代表者競争的資金
- 科学研究費補助金／若手研究(B), 2012年04月 - 2015年03月, 研究代表者競争的資金