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今福 仁美医学部附属病院 総合周産期母子医療センター講師
研究活動情報
■ 論文- Elsevier BV, 2025年09月, European Journal of Obstetrics & Gynecology and Reproductive Biology, 313, 114591 - 114591研究論文(学術雑誌)
- Elsevier BV, 2025年07月, Taiwanese Journal of Obstetrics and Gynecology, 64(4) (4), 703 - 706研究論文(学術雑誌)
- Primary hyperparathyroidism (PHPT) during pregnancy is rare, causing severe pregnancy complications. We report a pregnant woman with PHPT and a pregnancy complication history who underwent a single-gland parathyroidectomy during the second trimester and delivered at term. A 28-year-old pregnant woman, gravida 3, para 2, was referred to our hospital at 9 gestational weeks (GWs) because of previous intrauterine fetal death, preterm birth, and fetal growth restriction. She was diagnosed with PHPT during her second pregnancy, and her baby experienced neonatal hypocalcemia. However, she received no PHPT treatment afterward. Laboratory tests and neck ultrasound revealed hyperparathyroidism and an enlarged right superior parathyroid gland. She underwent a right superior parathyroidectomy at 24 GWs. She delivered a 2,136 g (-1.74 SD) healthy female infant at 37 GWs, and her baby demonstrated no neonatal hypocalcemia. Parathyroidectomy, even during pregnancy, should be considered among pregnant women with PHPT having a pregnancy or neonatal complication history.2025年05月, The Kobe journal of medical sciences, 71(1) (1), E41-E45, 英語, 国内誌研究論文(学術雑誌)
- Abstract Background Torasemide, a loop diuretic, is rarely used for pregnant women because of the risk of reduced placental blood flow resulting from decreased circulating plasma volume. We experienced a case of a newborn with metabolic alkalosis and mild polyuria. The mother was suspected of self-medicating as we detected torasemide in the neonatal serum by LC-MS/MS method. Case presentation A Japanese pregnant woman in her 20s with mental illness, symptoms of panic and eating disorders, and a history of overdosing on over-the-counter medications, was referred to our hospital for birth control. She presented with vomiting following bulimia nervosa and hypokalemia. Her baby was delivered vaginally at 36 weeks and 4 days of gestation. The baby’s blood gas analysis on day 0 revealed metabolic alkalosis (pH > 7.42, HCO3 - > 28 mmHg). Up to 16 h after birth, mild polyuria and a urine output of 3.3 mL/kg/h were observed without the administration of diuretics. We suspected diuretic intake by the mother before delivery, because she had a history of taking torasemide before being referred to the hospital. As expected, torasemide was detected in the baby’s serum. The serum concentration on the first day after delivery (4.80 ng/mL) gradually decreased to 0.45 ng/mL on day 5, whereas torasemide was not detected in the maternal serum. Neonatal metabolic alkalosis improved by day 3 following birth. Conclusions This case suggests close counseling and monitoring of pregnant women before childbirth regarding their past and present use of drugs, particularly in those with mental illness.Springer Science and Business Media LLC, 2025年04月, Journal of Pharmaceutical Health Care and Sciences, 11(1) (1)研究論文(学術雑誌)
- BACKGROUND: Brexpiprazole is a second-generation antipsychotic approved in Japan in 2018; however, information on placental passage and breast milk transfer remains limited. In this report, the patient, a 30-year-old pregnant woman with schizophrenia, was medicated with brexpiprazole, risperidone, and quetiapine. METHODS: The study used high-performance liquid chromatography-tandem mass spectrometry to determine the concentrations of brexpiprazole, quetiapine, risperidone, and its active metabolite (paliperidone) in maternal and neonatal plasma, cord venous plasma, and breast milk. Maternal plasma samples were obtained approximately 2 and 8 hours after the last administration of antipsychotics on the day of delivery and at the estimated drugs' trough time on days 1, 3, and 5 after delivery. RESULTS: The maternal plasma concentrations of brexpiprazole, quetiapine, and paliperidone increased by approximately 3.5-fold on the fifth day compared with those on the day of delivery, whereas the risperidone concentration remained almost constant. Moreover, the neonatal plasma concentrations of the 4 drugs immediately after birth were indistinguishable from the umbilical cord concentrations and gradually decreased, except for risperidone. Relative infant doses of these compounds were below 1.1%. CONCLUSIONS: Pregnancy status notably alters the pharmacokinetic properties of antipsychotics. Therefore, close and careful monitoring of clinical symptoms should be considered during pregnancy and after delivery. Although brexpiprazole is transferred to neonates through the placenta, breastfeeding is still possible because the relative infant dose value of this drug was much less than 10%.2024年10月, Therapeutic drug monitoring, 46(5) (5), 687 - 691, 英語, 国際誌研究論文(学術雑誌)
- ABSTRACT Aims/Introduction This study aimed to evaluate the problems in screening for gestational diabetes mellitus (GDM) by casual blood glucose (CBG) measurements at 24–28 gestational weeks. Materials and Methods Overall, 763 pregnant women who underwent the 50‐g glucose challenge test (GCT) at 24–28 gestational weeks were enrolled. The preload blood glucose (0‐h BG) level of 50‐g GCT was considered as CBG. Results A total of 240 women with BG levels at 1‐h after loading (1‐h BG) on 50‐g GCT ≥140 mg/dL underwent the 75‐g oral glucose tolerance test, and 98 (40.8%) were diagnosed with GDM. Of the 99 women with GDM, 71 (71.7%) had 0‐h BG on 50‐g GCT <100 mg/dL. Conclusions This study, where pregnant women underwent both CBG and 50‐g GCT simultaneously, showed that when CBG at 24–28 gestational weeks ≥100 mg/dL alone was used for screening GDM, many pregnant women with GDM were overlooked.Wiley, 2024年09月, Journal of Diabetes Investigation, 15(12) (12), 1797 - 1802研究論文(学術雑誌)
- Congenital cytomegalovirus (cCMV) infection is the most common congenital infection in developed countries. Although a standard therapy has not yet been established, evidence for the management of cCMV infection has been accumulating. The first edition of the “Clinical Practice Guidelines for the Management of Congenital Cytomegalovirus Infection” was published in Japan in 2023. This summary outlines the clinical questions (CQs) in the guidelines, with reference to the Japanese Medical Information Distribution Service Manual. Overall, 20 CQs with statements regarding prenatal risk assessment, prevention and management at diagnosis (CQs 1-1–1-3), diagnosis (CQs 2-1–2-6), treatment (CQs 3-1–3-7) and follow-up requirements (CQs 4-1–4-4) have been discussed. For each statement, the levels of recommendation, evidence and consensus rates were determined. These guidelines will assist in the management of patients with cCMV infection.Ovid Technologies (Wolters Kluwer Health), 2024年07月, Pediatric Infectious Disease Journal, 43(11) (11), e390 - e396研究論文(学術雑誌)
- Hemolysis, elevated liver enzyme levels, and low platelet count (HELLP) syndrome is one of the most severe complications of hypertensive disorders of pregnancy. HELLP syndrome occurring before 22 gestational weeks (GWs) is extremely rare, and patients prevalently exhibit underlying maternal diseases or fetal abnormalities. Here, we report the case of a pregnant woman who had HELLP syndrome at 20 GWs without any obvious underlying maternal diseases or fetal abnormalities. A 38-year-old pregnant woman was referred to Kobe University Hospital from another hospital at 19 + 5/7 GWs for hypertension, proteinuria, generalized edema, and fetal growth restriction. She was diagnosed with partial HELLP syndrome according to the Mississippi classification at 20 + 2/7 GWs. The patient was managed following the Mississippi protocol, including intravenous dexamethasone, magnesium sulfate, and antihypertensive drugs. She received intensive blood pressure and laboratory data monitoring using an arterial line and additional treatments, including platelet transfusion, intravenous haptoglobin infusion, and human atrial natriuretic peptide. The pregnancy ended in an induced delivery at 20 + 3/7 GWs, and she was discharged without complications 10 days postnatal. We performed laboratory tests for diagnosing underlying diseases but identified no obvious underlying diseases. This report indicates that early and intensive treatment of patients with HELLP syndrome occurring before 22 GWs according to the Mississippi protocol may enable clinicians to complete pregnancy termination without maternal complications and provide useful information to clinical practitioners in perinatal medicine.2024年04月, The Kobe journal of medical sciences, 70(1) (1), E22-E25, 英語, 国内誌研究論文(学術雑誌)
- Abstract Aims/Introduction To evaluate the efficacy of sensor‐augmented pump (SAP) for improving obstetric and neonatal outcomes among pregnant women with type 1 diabetes mellitus by comparing it with continuous subcutaneous insulin infusion plus self‐monitoring of blood glucose (continuous subcutaneous insulin infusion [CSII]/SMBG). Materials and Methods This retrospective cohort study included 40 cases of pregnancy complicated by type 1 diabetes mellitus treated with SAP (SAP group), and 29 cases of pregnancy complicated by type 1 diabetes mellitus treated with CSII/SMBG (CSII/SMBG group). The obstetric and neonatal outcomes were compared between the two groups. Results The median of the glycoalbumin levels in the first (18.8% vs 20.9%; P < 0.05) and second (15.4% vs 18.0%; P < 0.05) trimesters, the hemoglobin A1c levels in the peripartum period (6.1% vs 6.5%; P < 0.05) and the standard deviation score of birthweights (0.36 vs 1.52; P < 0.05) were significantly lower in the SAP group than in the CSII/SMBG group. The incidence rate of large for gestational age newborns was significantly lower in the SAP group than in the CSII/SMBG group (27.5% vs 65.5%; P < 0.05). No significant differences in the incidence rates of hypertensive disorders of pregnancy, small for gestational age, respiratory distress syndrome, neonatal hypoglycemia, hypervolemia and hyperbilirubinemia were observed between the groups. Conclusion The present study showed that SAP therapy is more effective in preventing large for gestational age newborns in pregnant women with type 1 diabetes mellitus than CSII/SMBG.Wiley, 2023年09月, Journal of Diabetes Investigation, 14(12) (12), 1383 - 1390研究論文(学術雑誌)
- 日本産婦人科・新生児血液学会, 2023年03月, 日本産婦人科・新生児血液学会誌, 32(2) (2), 27 - 33, 日本語
- This study aimed to determine the effects of pregnancy and ontogeny on risperidone and paliperidone pharmacokinetics by assessing their serum concentrations in two subjects and constructing a customized physiologically-based pharmacokinetic (PBPK) model. Risperidone and paliperidone serum concentrations were determined in a pregnant woman and her newborn. PBPK models for risperidone and paliperidone in adults, pediatric, and pregnant populations were developed and verified using the Simcyp simulator. These models were then applied to our two subjects, generating their "virtual twins." Effects of pregnancy on both drugs were examined using models with fixed pharmacokinetic parameters. In the neonatal PBPK simulation, 10 different models for estimating the renal function of neonates were evaluated. Risperidone was not detected in the serum of both pregnant woman and her newborn. Maternal and neonatal serum paliperidone concentrations were between 2.05-3.80 and 0.82-1.03 ng/ml, respectively. Developed PBPK models accurately predicted paliperidone's pharmacokinetics, as shown by minimal bias and acceptable precision across populations. The individualized maternal model predicted all observed paliperidone concentrations within the 90% prediction interval. Fixed-parameter simulations showed that CYP2D6 activity largely affects risperidone and paliperidone pharmacokinetics during pregnancy. The Flanders metadata equation showed the lowest absolute bias (mean error: 22.3% ± 6.0%) and the greatest precision (root mean square error: 23.8%) in predicting paliperidone plasma concentration in the neonatal population. Our constructed PBPK model can predict risperidone and paliperidone pharmacokinetics in pregnant and neonatal populations, which could help with precision dosing using the PBPK model-informed approach in special populations.2023年01月, Clinical and translational science, 英語, 国際誌研究論文(学術雑誌)
- Congenital cytomegalovirus infection (cCMV) can cause fetal growth restriction (FGR) and severe sequelae in affected infants. Clinicians generally suspect cCMV based on multiple ultrasound (US) findings associated with cCMV. However, no studies have assessed the diagnostic accuracy of fetal US for cCMV-associated abnormalities in FGR. Eight FGR and 10 non-FGR fetuses prenatally diagnosed with cCMV were examined by undergoing periodic detailed US examinations, as well as postnatal physical and imaging examinations. The diagnostic accuracy of prenatal US for cCMV-associated abnormalities was compared between FGR and non-FGR fetuses with cCMV. The diagnostic sensitivity rates of fetal US for cCMV-related abnormalities in FGR vs. non-FGR fetuses were as follows: ventriculomegaly, 66.7% vs. 88.9%; intracranial calcification, 20.0% vs. 20.0%; cysts and pseudocysts in the brain, 0% vs. 0%; ascites, 100.0% vs. 100.0%; hepatomegaly, 40.0% vs. 100.0%; splenomegaly, 0% vs. 0%. The diagnostic sensitivity of fetal US for hepatomegaly and ventriculomegaly in FGR fetuses with cCMV was lower than that in non-FGR fetuses with cCMV. The prevalence of severe long-term sequelae (e.g., bilateral hearing impairment, epilepsy, cerebral palsy, and severe developmental delay) in the CMV-infected fetuses with FGR was higher, albeit non-significantly. Clinicians should keep in mind the possibility of overlooking the symptoms of cCMV in assessing fetuses with FGR.2023年01月, Diagnostics (Basel, Switzerland), 13(2) (2), 英語, 国際誌研究論文(学術雑誌)
- 「産婦人科の進歩」編集室, 2022年08月, 産婦人科の進歩, 74(3) (3), 466 - 468, 日本語
- 日本女性栄養・代謝学会, 2022年05月, 日本女性栄養・代謝学会誌, 27(2) (2), 131 - 131, 日本語
- AIM: The aim of this prospective cohort study was to evaluate the risk factors for postpartum glucose intolerance (GI) in women with gestational diabetes mellitus (GDM). METHOD: A total of 140 women with GDM were enrolled. Of these, 115 underwent a 75-g oral glucose tolerance test (OGTT) at 12 weeks after delivery. Clinical factors and parameters in the antepartum 75-g OGTT associated with postpartum GI were evaluated by logistic regression analyses. RESULTS: Twenty-two (19.1%) of the 115 women with GDM developed postpartum GI. The univariate and multivariable logistic regression analyses revealed that low oral disposition index (DI) was a risk factor for postpartum GI (OR, 0.2; 95% CI, 0.04-0.7; p < 0.05), and that no clinical factors were associated with postpartum GI. CONCLUSIONS: Lower oral DI on the antepartum 75-g OGTT may be a useful marker for identifying GDM women who are at high risk for postpartum GI.2022年01月, The journal of obstetrics and gynaecology research, 英語, 国際誌研究論文(学術雑誌)
- Congenital cytomegalovirus (CMV) infection may cause severe long-term sequelae. Recent studies have demonstrated that early antiviral therapy for infants with symptomatic congenital CMV (cCMV) infection may improve neurological outcomes; thus, accurate identification of newborns at high risk of cCMV infection may contribute to improved outcomes in affected children. However, maternal serological screening for cCMV infection by diagnosing primary infection during pregnancy, which is a popular screening strategy, is inefficient, because the number of cCMV infections with nonprimary causes, including reactivation of or reinfection with CMV, is larger than that of cCMV infections with primary causes. Low levels of neutralizing antibodies against pentameric complex and potent CMV-specific T cell-mediated immune responses are associated with an increased risk of cCMV infection. Conversely, our prospective cohort studies revealed that the presence of maternal fever/flu-like symptoms, threatened miscarriage/premature delivery, or actual premature delivery are risk factors for cCMV infection among both women with normal pregnancies and those with high-risk ones, regardless of whether the infection is primary or nonprimary. This review focused on host immune responses to human CMV and current knowledge of potential biological and clinical factors that are predictive of cCMV infection.2021年12月, International journal of molecular sciences, 22(24) (24), 英語, 国際誌研究論文(学術雑誌)
- Placental mesenchymal dysplasia (PMD) is a rare placental abnormality that is closely related to severe pregnancy complications. A 27-year-old woman with fetal growth restriction and placenta previa was referred to a university hospital at 22 gestational weeks (GW). She was suspected of having a twin pregnancy with a complete or partial hydatidiform mole and coexisting normal live fetus, because two separate placentas, an enlarged one with multiple cystic lesions and a normal one, were shown on ultrasound examinations. At 27 GW, she experienced a sudden intrauterine fetal death (IUFD) after bleeding due to placenta previa, despite confirmation of fetal well-being at 2 h before bleeding. After delivery, histopathological examination confirmed the diagnosis of PMD. This is the first documented case of a woman with PMD and placenta previa who had a sudden IUFD after bleeding. Patients with both PMD and placenta previa should be considered at extremely high risk for IUFD.2021年11月, The journal of obstetrics and gynaecology research, 47(11) (11), 4087 - 4092, 英語, 国際誌
- 「産婦人科の進歩」編集室, 2021年10月, 産婦人科の進歩, 73(4) (4), 500 - 500, 日本語
- A 40-year-old primigravida woman with a monochorionic-triamniotic (MT) triplet pregnancy was hospitalized due to threatened abortion at 16 gestational weeks. Polyhydramnios in two fetuses and oligohydramnios in the third supported a diagnosis of feto-fetal transfusion syndrome (FFTS) at 23 weeks and 3 days of gestation. Severe dyspnea and liver dysfunction required intensive care unit admission and mechanical ventilation support, and abdominal compartment syndrome (ACS) caused by polyhydramnios was clinically diagnosed. When her general condition was not improved regardless of intensive care, the patient delivered the three fetuses by cesarean section at 23 weeks and 5 days gestation. Abdominal decompression was achieved with delivery, and the patient was discharged 13 days after operation without morbidity. This is the first case report of ACS caused by FFTS in a MT triplet pregnancy resulting in extremely preterm birth.2021年09月, The journal of obstetrics and gynaecology research, 47(9) (9), 3370 - 3373, 英語, 国際誌
- INTRODUCTION: Placenta accreta spectrum (PAS) is a life-threating obstetric complication, and prenatal prediction of PAS can decrease maternal morbidity and mortality. The aim of this prospective cohort study was to determine the clinical factors associated with PAS. METHODS: Pregnant women who delivered at a university hospital were enrolled. Clinical data were collected from medical records, and logistic regression analyses were performed to determine which clinical factors were associated with PAS. RESULTS: Eighty-seven (2.1%) of the 4146 pregnant women experienced PAS. Multivariable analyses revealed that a prior history of cesarean section (CS) (OR 3.3; 95% CI 1.9-5.7; p < 0.01), dilation and curettage (D&C) (OR 2.8; 95% CI 1.7-4.6; p < 0.01), hysteroscopic surgery (OR 5.7; 95% CI 2.3-14.4; p < 0.01), uterine artery embolization (UAE) (OR 44.1; 95% CI 13.8-141.0; p < 0.01), current pregnancy via assisted reproductive technology (ART) (OR 4.1; 95% CI 2.4-7.1; p < 0.01), and the presence of placenta previa in the current pregnancy (OR 13.1; 95% CI 7.9-21.8; p < 0.01) were independently associated with the occurrence of PAS. CONCLUSION: Pregnant women who have a prior history of CS, D&C, hysteroscopic surgery, UAE, current pregnancy via ART, and the presence of placenta previa in the current pregnancy are high risk for PAS.2021年09月, Placenta, 112, 180 - 184, 英語, 国際誌研究論文(学術雑誌)
- (一社)日本周産期・新生児医学会, 2021年06月, 日本周産期・新生児医学会雑誌, 57(Suppl.) (Suppl.), P163 - P163, 日本語非初感染母体から出生した重篤な症候性先天性サイトメガロウイルス感染症児の一例
- (一社)日本周産期・新生児医学会, 2021年06月, 日本周産期・新生児医学会雑誌, 57(Suppl.) (Suppl.), P163 - P163, 日本語非初感染母体から出生した重篤な症候性先天性サイトメガロウイルス感染症児の一例
- (一社)日本周産期・新生児医学会, 2021年06月, 日本周産期・新生児医学会雑誌, 57(Suppl.) (Suppl.), P177 - P177, 日本語胎児治療と新生児治療の併用は先天性サイトメガロウイルス感染症児の予後を改善する
- (一社)日本産婦人科感染症学会, 2021年05月, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 37回, 53 - 53, 日本語トキソプラズマ-IgG avidity index高値母体から発生した先天性トキソプラズマ感染疑いの1例
- 「産婦人科の進歩」編集室, 2021年05月, 産婦人科の進歩, 73(2) (2), 137 - 137, 日本語
- (一社)日本産婦人科感染症学会, 2021年05月, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 37回, 43 - 43, 日本語梅毒合併妊娠8例の検討
- (一社)日本産婦人科感染症学会, 2021年05月, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 37回, 50 - 50, 日本語周産期母子医療センターでの先天性サイトメガロウイルス感染に関与する臨床所見
- 「産婦人科の進歩」編集室, 2021年05月, 産婦人科の進歩, 73(2) (2), 152 - 152, 日本語
- Infants with symptomatic congenital cytomegalovirus infection (cCMV) suffer from long-term sequelae. This study aimed at evaluating the efficacy of combining immunoglobulin (Ig) fetal therapy (FT) and neonatal therapy (NT) with antiviral drugs to improve neurological outcomes of affected infants. Women whose fetuses had symptomatic cCMV received Ig injection into the fetal peritoneal cavity and/or maternal blood as FT, while affected newborns received oral valganciclovir or intravenous ganciclovir as NT. We compared the neurological outcomes at ≥18 months old between infants receiving FT with or without NT (FT group) and those receiving NT only (NT group). From 2009-2019, 15 women whose fetuses had symptomatic cCMV received FT, while 19 newborns received NT only. In FT group, two newborns died, and two were <18 months old. Neurological outcomes of the remaining 11 infants in FT group were as follows: normal 45.5 %, mild impairments 36.4 %, and severe impairments 18.2 %. In NT group, one newborn died, one's parents refused the follow-up, one was <18 months old, and two had only chorioretinitis as symptoms. Neurological outcomes of the remaining 14 infants in NT group were as follows: normal 21.4 %, mild impairments 14.3 %, and severe impairments 64.3 %. The proportion of infants with severe impairments in FT group was significantly lower than that in NT group (18.2 % vs 64.3 %, p < 0.05). This is the first trial demonstrating that the combination of Ig FT and NT with antiviral drugs may be more effective in improving neurological outcomes of newborns with symptomatic cCMV as compared to NT only.2020年12月, Journal of reproductive immunology, 143, 103263 - 103263, 英語, 国際誌研究論文(学術雑誌)
- This prospective cohort study aimed to determine clinical factors associated with congenital cytomegalovirus (CMV) infection in pregnancy. Newborns born at a perinatal medical center received PCR analyses for CMV-DNA in their urine with informed consent. Clinical data, including age, maternal fever or flu-like symptoms, complications, ultrasound fetal abnormality, gestational weeks at delivery, and birth weight, were collected. Logistic regression analyses determined clinical findings associated with congenital CMV infection (cCMV). cCMV was diagnosed in 32 of 4380 pregnancies. Univariate and multivariable analyses revealed that age < 25 years old (OR 2.7, 95% CI 1.1-6.6; p < 0.05), the presence of maternal fever or flu-like symptoms (5.4, 2.6-11.2; p < 0.01), ultrasound fetal abnormalities (12.7, 5.8-27.7; p < 0.01), and preterm delivery at less than 34 gestational weeks (2.6, 1.1-6.0; p < 0.05) were independent clinical findings associated with cCMV. A combination of maternal fever/flu-like symptoms, ultrasound fetal abnormalities, or preterm delivery at less than 34 gestational weeks as optimal predictive factors showed 90.6% sensitivity, 66.4% specificity, and a maximum Youden index of 0.57. CMV-DNA tests in the urine of newborns born to mothers with these clinical manifestations may be an effective method in detecting cCMV as a targeted screening with a high sensitivity.2020年11月, Scientific reports, 10(1) (1), 19706 - 19706, 英語, 国際誌研究論文(学術雑誌)
- 「産婦人科の進歩」編集室, 2020年10月, 産婦人科の進歩, 72(4) (4), 458 - 458, 日本語精神疾患合併妊娠の妊娠中・産後増悪誘因ならびに児への影響に関する検討
- 「産婦人科の進歩」編集室, 2020年05月, 産婦人科の進歩, 72(2) (2), 162 - 162, 日本語トキソプラズマIgG avidity index高値母体から発生した先天性トキソプラズマ感染疑いの1例
- 「産婦人科の進歩」編集室, 2020年05月, 産婦人科の進歩, 72(2) (2), 177 - 177, 日本語妊娠糖尿病妊婦におけるHeavy For Date児出生の予測因子
- Congenital syphilis may lead to severe sequelae in affected infants. The prevalence of syphilis in women of childbearing age has increased worldwide. From 2015 to 2018, we encountered eight pregnant women with syphilis including six with late latent and two with early latent syphilis. Seven pregnant women with syphilis received antibiotic therapies of oral amoxicillin, intravenous penicillin G, or the both. The syphilotherapies in four cases were considered effective, because rapid plasma reagin titers decreased. None of the seven pregnant women who received syphilotherapies had congenital syphilis. The remaining one woman who did not undergo a maternity checkup or syphilotherapy delivered a stillbirth with congenital syphilis at 29 gestational weeks.2020年03月, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 26(3) (3), 298 - 300, 英語, 国際誌[査読有り]
- AIM: To evaluate pregnancy outcome and complications in subsequent pregnancies after severe post-partum hemorrhage (PPH) between women with and without a history of uterine artery embolization (UAE). METHODS: Women who had a history of severe PPH, and delivered newborns at ≥22 gestational weeks in subsequent pregnancies were enrolled. Severe PPH was defined as blood loss volume of more than 2000 mL. RESULTS: The blood loss volume (median 1581 mL) in women with UAE (n = 14) was significantly more than that in women without UAE (median 1021 mL, n = 32, P < 0.01), and the recurrence rate of severe PPH in women with UAE (n = 5, 35.7%) was significantly higher than that in women without UAE (n = 3, 9.4%, P < 0.05). There were no significant differences in frequencies of premature delivery, hypertensive disorders of pregnancy, fetal growth restriction, or placenta previa/low lying placenta. Of 14 women with UAE, 7 (50.0%) had abnormally invasive placenta, whereas of 32 women without UAE, none had abnormally invasive placenta. CONCLUSION: Subsequent pregnancies after UAE for severe PPH had high risks for recurrence of severe PPH.2020年01月, The journal of obstetrics and gynaecology research, 46(1) (1), 119 - 123, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- 日本女性栄養・代謝学会, 2019年09月, 日本女性栄養・代謝学会学術集会プログラム・抄録集, 43回, 64 - 64, 日本語子宮頸部上皮内新生物(CIN)合併妊娠における保存的管理に関する検討
- (一社)日本産婦人科感染症学会, 2019年09月, 日本産婦人科感染症学会誌, 3(1) (1), 87 - 87, 日本語症候性先天性サイトメガロウイルス感染症に対する胎児治療と新生児治療の有効性
- (一社)日本産婦人科感染症学会, 2019年09月, 日本産婦人科感染症学会誌, 3(1) (1), 87 - 87, 日本語症候性先天性サイトメガロウイルス感染症に対する胎児治療と新生児治療の有効性
- S.O.G. CANADA Inc., 2019年, European Journal of Gynaecological Oncology, 40(4) (4), 563 - 566, 英語研究論文(学術雑誌)
- (公社)日本母性衛生学会, 2018年09月, 母性衛生, 59(3) (3), 293 - 293, 日本語
- (公社)日本母性衛生学会, 2018年09月, 母性衛生, 59(3) (3), 311 - 311, 日本語
- (一社)日本周産期・新生児医学会, 2018年06月, 日本周産期・新生児医学会雑誌, 54(2) (2), 615 - 615, 日本語
- (一社)日本周産期・新生児医学会, 2018年06月, 日本周産期・新生児医学会雑誌, 54(2) (2), 638 - 638, 日本語
- We aim to clarify the incidence of deep venous thrombosis (DVT) before treatment in women with ovarian cancer and identify risk factors for DVT.In this prospective study, 110 women underwent venous ultrasonography before cancer treatment and D-dimer levels were measured. We investigated factors predicting DVT by logistic regression.DVT was detected in 25 of 110 women (22.7%) and pulmonary thromboembolism was coexisted in 2 women (1.8%). A total of 21 women (84.4%) with DVT were asymptomatic. D-dimer levels in women with DVT (median, 10.9; range, <0.5-98.2 μg/mL) were significantly higher than those in women without DVT (2.0; <0.5-60.8 μg/mL; P < .01). When 10.9 μg/mL was used as a cutoff value for D-dimer levels to predict DVT, specificity, sensitivity, and positive and negative predictive values were 92.9%, 52.0%, 68.4%, and 86.8%, respectively. The multivariate analysis demonstrated that D-dimer level (odds ratio [OR], 19.7; 95% confidence interval [CI], 5.89-76.76) and clear cell histology (OR, 7.1; 95% CI, 2.12-25.67) were independent factors predicting DVT.Asymptomatic DVT occurred with great frequency before treatment in patients with ovarian cancer. High D-dimer level and clear cell pathology is associated with a higher DVT risk.2018年06月, Medicine (Baltimore), 97(23) (23), e11009, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- Ultrasound and MRI Findings of Twin Pregnancies with Complete Hydatidiform Mole and Coexisting Normal Fetus: Two Case Reports.BACKGROUND: Both twin pregnancies with complete hydatidiform mole and coexisting normal fetus (CHMCF) and partial hydatidiform mole can be found in association with a live fetus and a placenta displaying a molar degeneration. Two cases of CHMCF using magnetic resonance imaging (MRI) for a diagnosis are reported. CASE: In the first, CHMCF was suspected at 12 weeks of gestation. At 18 weeks of gestation, the existence of molar placenta and a sac separating from fetus and normal placenta was clearly depicted on MRI. At 19 weeks of gestations, she had termination of pregnancy because of a development of gestational trophoblastic neoplasia (GTN) and started chemotherapy. In the second case, CHMCF was suspected at 14 weeks of gestation. MRI demonstrated the existence of molar placenta and a sac separating from fetus and normal placenta. She chose induced abortion and there was no evidence of GTN during the 1 year-follow up period. Pathological examination in both cases was consistent with a complete hydration mole and a coexisting normal female fetus. CONCLUSION: MRI was useful for an accurate diagnosis for CHMCF.2018年05月, The Kobe journal of medical sciences, 64(1) (1), E1-E5 - E5, 英語, 国内誌[査読有り]研究論文(学術雑誌)
- (一社)日本産科婦人科内視鏡学会, 2018年04月, 日本産科婦人科内視鏡学会雑誌, 34(1) (1), 174 - 178, 日本語
- 「産婦人科の進歩」編集室, 2017年10月, 産婦人科の進歩, 69(4) (4), 507 - 507, 日本語子宮頸部細胞診AGC症例の病理組織学的検討と転帰
- (一社)日本産科婦人科内視鏡学会, 2017年08月, 日本産科婦人科内視鏡学会雑誌, 33(Suppl.I) (Suppl.I), 616 - 616, 日本語当科におけるアテロコラーゲン膜を用いた造腟術の成績
- (公社)日本婦人科腫瘍学会, 2017年06月, 日本婦人科腫瘍学会雑誌, 35(3) (3), 555 - 555, 日本語子宮体部病変に対する病理診断が困難な症例においてFDG-PET検査は治療方針決定に有用である
- 「産婦人科の進歩」編集室, 2017年05月, 産婦人科の進歩, 69(2) (2), 222 - 222, 日本語
- 「産婦人科の進歩」編集室, 2017年05月, 産婦人科の進歩, 69(2) (2), 238 - 238, 日本語
- 「産婦人科の進歩」編集室, 2016年05月, 産婦人科の進歩, 68(2) (2), 212 - 212, 日本語
- 2016年04月, 日本臨床細胞学会雑誌, 55(Suppl.1) (Suppl.1), 191, 日本語子宮内膜細胞診陽性と判定するも組織学的に体癌の診断にいたらなかった2症例の検討研究論文(その他学術会議資料等)
- 2015年10月, 日本臨床細胞学会雑誌, 54(Suppl.2) (Suppl.2), 546, 日本語ASC-H症例の病理組織診断および臨床経過に関する検討[査読有り]研究論文(その他学術会議資料等)
- (公社)日本婦人科腫瘍学会, 2014年06月, 日本婦人科腫瘍学会雑誌, 32(3) (3), 590 - 590, 日本語子宮体癌根治術における廓清リンパ節および子宮筋層にリンパ脈管筋腫症細胞を認めた一例[査読有り]
- (一社)日本遺伝カウンセリング学会, 2023年06月, 日本遺伝カウンセリング学会誌, 44(2) (2), 156 - 156, 日本語
- (一社)日本周産期・新生児医学会, 2021年06月, 日本周産期・新生児医学会雑誌, 57(Suppl.) (Suppl.), P177 - P177, 日本語胎児治療と新生児治療の併用は先天性サイトメガロウイルス感染症児の予後を改善する
- (一社)日本産婦人科感染症学会, 2021年05月, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 37回, 52 - 52, 日本語産科一次施設における先天性サイトメガロウイルス感染症発生の臨床的リスク因子
- 2021年, 日本周産期・新生児医学会雑誌(Web), 57(Suppl) (Suppl)非初感染母体から出生した重篤な症候性先天性サイトメガロウイルス感染症児の一例
- 2021年, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 37th不育症と子宮内膜マイクロバイオームとの関連
- (公社)日本臨床細胞学会, 2019年07月, 日本臨床細胞学会雑誌, 58(4) (4), 162 - 166, 日本語子宮頸部細胞診ASC-H判定例の臨床的取り扱い 病理組織診断および転帰に関する検討
- 「産婦人科の進歩」編集室, 2019年02月, 産婦人科の進歩, 71(1) (1), 9 - 16, 日本語正常胎児と全奇胎の双胎(complete hydatidiform mole coexistent with a fetus)の3症例
- (一社)日本生殖医学会, 2018年08月, 日本生殖医学会雑誌, 63(3) (3), 230 - 230, 日本語不育症のトピックス 不育症とネオ・セルフ
- 2016年11月, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 125 - 125, 英語研究発表ペーパー・要旨(国際会議)
- 日本産科婦人科学会, 2016年, 日本産科婦人科學會雜誌, 68(2) (2), 831 - 831, 日本語P3-6-1 婦人科悪性腫瘍治療前患者における深部静脈血栓症のリスク因子の検討(Group 71 深部静脈血栓・肺塞栓症・脳梗塞,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)
- 日本産科婦人科学会, 2016年, 日本産科婦人科學會雜誌, 68(2) (2), 699 - 699, 日本語P2-31-11 子宮頸癌IB期・II期の検討 : 手術療法と放射線療法の比較(Group31 子宮頸癌・治療2・合併症・予後因子,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 668 - 668, 日本語P2-7-8 骨盤リンパ膿瘍における経皮的CTガイド下ドレナージに関する検討(Group48 感染症,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 657 - 657, 日本語P2-4-5 PET-CT所見で決定した進行子宮頸癌の放射線療法照射範囲と予後(Group45 子宮頸部腫瘍 症例検討,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 711 - 711, 日本語P2-24-3 子宮体癌根治術における廓清リンパ節および子宮筋層に認めたリンパ脈管筋腫症細胞(Group 65 良性・悪性腫瘍 症例1,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 830 - 830, 日本語P3-5-4 子宮頸癌放射線療法の検討 : 放射線単独療法と同時化学放射線療法の比較(Group 107 子宮頸部腫瘍 治療2,一般演題,第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 537 - 537, 日本語P1-2-7 子宮頸部上皮内病変に対するHPVタイピング検査を併用した管理と治療(Group2 CIN診断,治療,その他2,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 539 - 539, 日本語P1-3-4 子宮頸部円錐切除術例の治療成績と妊娠予後(Group3 CIN診断,治療,その他3,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 849 - 849, 日本語P3-13-3 巨大卵巣腫瘍の診断と術後管理に関する検討(Group 115 卵巣腫瘍 治療1 進行癌の治療,一般演題,第67回学術講演会)
- 日本産科婦人科学会, 2014年02月01日, 日本産科婦人科学会雑誌, 66(2) (2), 627 - 627, 日本語卵巣奇形腫における悪性転化の術前予測についての検討
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 703 - 703, 日本語P2-42-12 癒着胎盤における絨毛細胞の上皮間葉変換に関する解析(Group 80 産科出血4,一般演題,第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 518 - 518, 日本語P1-18-4 婦人科癌術前PET-CTで発見された重複癌症例に関する臨床的検討(Group 18 悪性腫瘍全般・診断1,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 871 - 871, 日本語P3-39-2 ASC-H症例の臨床経過と細胞診所見に関する検討(Group 136 子宮頸部腫瘍・検診1,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 885 - 885, 日本語P3-44-9 転移性子宮腫瘍の診断に腹水セルブロック法が有用であった2症例(Group 141 子宮体部腫瘍・診断2,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 2014年, 日本エンドメトリオーシス学会プログラム・抄録集, 35th, 96, 日本語術前GnRH療法および術後ジエノゲスト療法を併用した水腎症合併重症子宮内膜症の2例
- 第63回日本新生児成育医学会学術集会, 2018年11月, 日本語, 東京, 国内会議母子感染:予防と対策 兵庫県の妊婦梅毒症例からみた梅毒母子感染の予防と対策における課題シンポジウム・ワークショップパネル(指名)
- 第33回日本生殖免疫学会総会・学術集会, 2018年11月, 日本語, 東京, 国内会議切迫流早産と腟内マイクロバイオームとの関連性口頭発表(一般)
- 第39回日本妊娠高血圧学会学術集会, 2018年11月, 日本語, 大阪, 国内会議維持透析療法を要した腎不全合併妊娠4例口頭発表(一般)
- 第59回日本母性衛生学会総会・学術集会, 2018年10月, 日本語, 新潟, 国内会議分娩後出血に対するUAEの帰結およびUAE後の妊娠についての検討ポスター発表
- 第59回日本母性衛生学会総会・学術集会, 2018年10月, 日本語, 新潟, 国内会議梅毒合併妊娠の7例口頭発表(一般)
- 第59回日本母性衛生学会総会・学術集会, 2018年10月, 日本語, 新潟, 国内会議神戸大学における不育症の臨床因子と妊娠予後の検討ポスター発表
- 第56回日本癌治療学会, 2018年10月, 英語, 横浜, 国内会議Risk factors for deep venous thrombosis in women with ovarian cancerポスター発表
- 第63回日本生殖医学会学術講演会・総会, 2018年09月, 日本語, 旭川, 国内会議不育症のトピックス~不育症とネオ・セルフシンポジウム・ワークショップパネル(指名)
- The 20th congress of federation of asia oceania perinatal societies (FAOPS), 2018年09月, 英語, Manila, 国際会議Pregnancy outcomes subsequent to uterine arterial embolization for severe post-partum hemorrhageポスター発表
- 第41回日本母体胎児医学会学術集会, 2018年08月, 日本語, 東京, 国内会議梅毒合併妊娠の7症例口頭発表(一般)
- 第92回兵庫県産婦人科学会学術集会, 2018年07月, 日本語, 神戸, 国内会議兵庫県産婦人科施設を対象とした梅毒アンケート調査結果と今後の課題口頭発表(一般)
- 第54回日本周産期・新生児医学会学術集会, 2018年07月, 日本語, 東京, 国内会議兵庫県における女性の梅毒症例の動向と課題口頭発表(一般)
- 第92回兵庫県産婦人科学会学術集会, 2018年07月, 日本語, 神戸, 国内会議切迫早産と腟内マイクロバイオームとの関連性の検討口頭発表(一般)
- 第54回日本周産期・新生児医学会学術集会, 2018年07月, 日本語, 東京, 国内会議症候性の先天性サイトメガロウイルス感染症に対する胎児治療と新生児治療口頭発表(一般)
- 第92回兵庫県産婦人科学会学術集会, 2018年07月, 日本語, 神戸, 国内会議最近管理した梅毒合併妊婦7症例口頭発表(一般)
- 第54回日本周産期・新生児医学会学術集会, 2018年07月, 日本語, 東京, 国内会議維持透析療法を要した腎不全合併妊娠3例口頭発表(一般)
- 第54回日本周産期・新生児医学会学術集会, 2018年07月, 日本語, 東京, 国内会議UAE後の妊娠では産後出血に注意が必要である口頭発表(一般)
- 第92回兵庫県産婦人科学会学術集会, 2018年07月, 日本語, 神戸, 国内会議CIN2患者に対するレーザー蒸散術の検討(第二報)口頭発表(一般)
- 第138回近畿産科婦人科学会総会, 2018年06月, 日本語, 大阪, 国内会議子宮頚部上皮内新生物(CIN)合併妊娠における保存的管理に関する検討口頭発表(一般)
- 第35回日本産婦人科感染症学会学術集会, 2018年05月, 日本語, 岐阜, 国内会議兵庫県における女性梅毒症例の動向と課題口頭発表(一般)
- 第35回日本産婦人科感染症学会学術集会, 2018年05月, 日本語, 岐阜, 国内会議症候性の先天性サイトメガロウイルス感染症に対する胎児治療と新生児治療の有効性口頭発表(一般)
- 第70回日本産科婦人科学会学術講演会, 2018年05月, 英語, 仙台, 国内会議Three cases of complete hydatidiform mole coexistent with a live twin fetusポスター発表
- 第70回日本産科婦人科学会学術講演会, 2018年05月, 英語, 仙台, 国内会議Risk Factors for Deep Venous Thrombosis in Women with Ovarian Cancerポスター発表
- 第70回日本産科婦人科学会学術講演会, 2018年05月, 英語, 仙台, 国内会議Pregnancy outcomes subsequent to uterine arterial embolization for severe post-partum hemorrhageポスター発表
- 第131回近畿産科婦人科学会学術集会, 2014年10月, 日本語, 近畿産婦人科学会, 大阪, 国内会議治療抵抗性の抗リン脂質抗体症候群合併妊娠に対する大量免疫グロブリン療法口頭発表(一般)
- 第131回近畿産科婦人科学会学術集会, 2014年10月, 日本語, 近畿産婦人科学会, 大阪, 国内会議子宮頸部円錐切除術施行例の治療成績と妊娠予後口頭発表(一般)
- 第54回日本産科婦人科内視鏡学会学術講演会, 2014年09月, 日本語, 日本産科婦人科内視鏡学会, 鹿児島, 国内会議腹腔鏡手術中に器具が破損した2症例口頭発表(一般)
- 第54回日本産科婦人科内視鏡学会学術講演会, 2014年09月, 日本語, 日本産科婦人科内視鏡学会, 鹿児島, 国内会議腹腔鏡下子宮全摘術における腟管切断時の工夫口頭発表(一般)
- 第32回日本クラミジア研究会, 2014年09月, 日本語, 日本産科婦人科学会, 京都, 国内会議クラミジア直腸炎の1例口頭発表(一般)
- 平成26年度位育会臨床セミナー, 2014年08月, 日本語, 位育会, 神戸, 国内会議当院における子宮頸癌に対する根治的放射線治療の現状口頭発表(一般)
- 25回近畿エンドメトリオージス研究会, 2014年08月, 日本語, 日本エン鳥オーシス学会, 大阪, 国内会議術前GnRH療法および術後ジエノゲスト療法を併用した水腎症合併子宮内膜症の2例口頭発表(一般)
- 第56回日本婦人科腫瘍学会学術講演会, 2014年07月, 日本語, 第56回日本婦人科腫瘍学会, 宇都宮, 国内会議婦人科癌術前PET-CTで発見された重複癌症例に関する臨床的検討口頭発表(一般)
- 第56回日本婦人科腫瘍学会学術講演会, 2014年07月, 日本語, 第57回日本婦人科腫瘍学会, 宇都宮, 国内会議子宮体癌根治術における廓清リンパ節および子宮筋層にリンパ脈管筋腫症細胞を認めた一例口頭発表(一般)
- 第56回日本婦人科腫瘍学会学術講演会, 2014年07月, 日本語, 第58回日本婦人科腫瘍学会, 宇都宮, 国内会議癌性腹膜炎との鑑別を要した結核性腹膜炎の1症例口頭発表(一般)
- 第130回近畿産科婦人科学会学術集会, 2014年06月, 日本語, 近畿産婦人科学会, 大阪, 国内会議婦人科癌術前PET-CTで発見された重複癌症例に関する臨床的検討口頭発表(一般)
- 第88回兵庫県産科婦人科学会学術集会, 2014年06月, 日本語, 日本産科婦人科学会, 神戸, 国内会議子宮頸部病変におけるHPVタイピングの意義口頭発表(一般)
- 第130回近畿産科婦人科学会学術集会, 2014年06月, 日本語, 近畿産婦人科学会, 大阪, 国内会議骨盤内から後腹膜腔へ発達した巨大なparasitic myomaの1例口頭発表(一般)
- 第88回兵庫県産科婦人科学会学術集会, 2014年06月, 日本語, 日本産科婦人科学会, 神戸, 国内会議癌性腹膜炎との鑑別が困難であった結核性腹膜炎の1例口頭発表(一般)
- 第31回日本産婦人科感染症研究会, 2014年06月, 日本語, 日本産婦人科感染症研究会, 神戸, 国内会議クラミジア直腸炎の1例口頭発表(一般)
- 第31回日本産婦人科感染症研究会, 2014年06月, 日本語, 日本産婦人科感染症研究会, 神戸, 国内会議CIN患者におけるHPVタイピング検査の臨床的意義口頭発表(一般)
- 第88回兵庫県産科婦人科学会学術集会, 2014年06月, 日本語, 日本産科婦人科学会, 神戸, 国内会議ASC-H症例の臨床経過と細胞診所見に関する検討口頭発表(一般)
- 第66回日本産科婦人科学会学術講演会, 2014年04月, 日本語, 日本産科婦人科学会, 東京, 国内会議卵巣奇形腫における悪性転化の術前予測についての検討ポスター発表
- 第66回日本産科婦人科学会学術講演会, 2014年04月, 日本語, 日本産科婦人科学会, 東京, 国内会議癒着胎盤における絨毛細胞の上皮間葉変換に関する解析ポスター発表
- 第66回日本産科婦人科学会学術講演会, 2014年04月, 日本語, 日本産科婦人科学会, 東京, 国内会議婦人科癌術前PET-CTで発見された重複癌症例に関する臨床的検討ポスター発表
- 第66回日本産科婦人科学会学術講演会, 2014年04月, 日本語, 日本産科婦人科学会, 東京, 国内会議転移性子宮腫瘍の診断に腹水セルブロック法が有用であった2症例ポスター発表
- 第66回日本産科婦人科学会学術講演会, 2014年04月, 日本語, 日本産科婦人科学会, 東京, 国内会議ASC-H症例の臨床経過と細胞診所見に関する検討ポスター発表
- 第19回兵庫県性感染症(STI)研究会, 2014年03月, 日本語, 神戸, 国内会議クラミジア直腸炎の1例口頭発表(一般)
- 第35回日本エンドメトリオーシス学会, 2014年01月, 日本語, 日本エンドリオーシス学会, 鹿児島, 国内会議術前GnRH療法および術後ジエノゲスト療法を併用した水腎症合併重症子宮内膜症の2例口頭発表(一般)