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亀岡 正典
大学院保健学研究科 保健学専攻
教授

研究者基本情報

■ 学位
  • 博士（医学）, 北海道大学
■ 研究ニュース
■ 研究キーワード
  • ヒト免疫不全ウイルス1型
  • エイズ
  • デング
  • ウイルス学
  • 新興・再興感染症
■ 研究分野
  • ライフサイエンス / ウイルス学

研究活動情報

■ 論文
  • Search for host factors involved in flavivirus life cycle.
    Misaki Yagi, Naoki Takegawa, Siti Churrotin, Ilham Harlan Amarullah, Chie Aiki-Utsubo, Masanori Kameoka
    2025年05月
    [査読有り]

  • Antimicrobial and antiviral activities and reaction mechanisms of an organic photocatalyst upon visible-light irradiation.
    Hayato Shiroma, Atsushi Chikamoto, Masanori Kameoka, Kazuo Kumagai, Hideto Matsuyama, Yuichi Ichihashi
    2025年04月, 51, 2591 - 2604, 英語
    [査読有り]

  • Siti Churrotin, Ilham Harlan Amarullah, Anisa Lailatul Fitria, Siti Qamariyah Khairunisa, Laura Navika Yamani, Masanori Kameoka, Novi Anggraeni, Robby Nurhariansyah, Dominicus Husada, Citrawati Dyah Kencono Wungu
    BACKGROUND: The simultaneous occurrence of the COVID-19 pandemic and a dengue outbreak has posed significant challenges for governments and medical personnel in dengue-endemic countries like Indonesia. Several studies in dengue-endemic countries have reported cases of misdiagnosis between COVID-19 and dengue. Therefore, it is crucial to evaluate the potential cross-reactivity between SARS-CoV-2 antibodies and dengue. METHODS: This study aimed to confirm the serological cross-reaction between dengue virus and SARS-CoV-2 in Surabaya, East Java, which is a highly dengue-endemic city in Indonesia. In total, 238 serum samples with confirmed dengue that were collected before the emergence of COVID-19 were tested to detect the presence of reacting IgG and IgM antibodies (Abs) against SARS-CoV-2 via a rapid detection test (RDT) and enzyme-linked immunosorbent assay (ELISA). Samples from patients with dengue infection collected during the pandemic, from healthy volunteers predating the pandemic, and from patients with COVID-19 were used for comparison. RESULTS AND CONCLUSION: Few (6.7 %) of the pre-COVID-19 dengue Ab-positive serum samples showed reactive on SARS-CoV-2 in the RDT, with significantly lower IgG and IgM levels detected in ELISA compared with the dengue samples collected during the pandemic and the COVID-19 samples (P < 0.005). A comparable anti-SARS-CoV-2 IgG concentration was observed in the pre-COVID-19 dengue samples and healthy volunteers (P = 0.56), which also indicated other possibilities. In conclusion, our results suggested a low risk of cross-reactivity between dengue virus and SARS-CoV-2. However, they highlighted the need for caution when using and interpreting data obtained stemming from serological methods, to prevent false-positive results. Further studies are needed to evaluate the cross-reactivity between dengue virus, SARS-CoV-2, and other common human pathogens, as well as its effect on the serosurveys, treatment of these diseases, or vaccine efficacy.
    2024年11月, Heliyon, 10(21) (21), e39099, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Chie Aoki-Utsubo, Masanori Kameoka, Lin Deng, Muhammad Hanafi, Beti Ernawati Dewi, Pratiwi Sudarmono, Takaji Wakita, Hak Hotta
    Statins, such as lovastatin, have been known to inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Statins were reported to moderately suppress hepatitis C virus (HCV) replication in cultured cells harboring HCV RNA replicons. We report here using an HCV cell culture (HCVcc) system that high concentrations of lovastatin (5-20 μg/mL) markedly enhanced the release of HCV infectious particles (virion) in the culture supernatants by up to 40 times, without enhancing HCV RNA replication, HCV protein synthesis, or HCV virion assembly in the cells. We also found that lovastatin increased the phosphorylation (activation) level of extracellular-signal-regulated kinase 5 (ERK5) in both the infected and uninfected cells in a dose-dependent manner. The lovastatin-mediated increase of HCV virion release was partially reversed by selective ERK5 inhibitors, BIX02189 and XMD8-92, or by ERK5 knockdown using small interfering RNA (siRNA). Moreover, we demonstrated that other cholesterol-lowering statins, but not dehydrolovastatin that is incapable of inhibiting HMG-CoA reductase and activating ERK5, enhanced HCV virion release to the same extent as observed with lovastatin. These results collectively suggest that statins markedly enhance HCV virion release from infected cells through HMG-CoA reductase inhibition and ERK5 activation.
    2024年07月, Microbiology and immunology, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Brian Eka Rachman, Siti Qamariyah Khairunisa, Citrawati Dyah Kencono Wungu, Tri Pudy Asmarawati, Musofa Rusli, Bramantono, M Vitanata Arfijanto, Usman Hadi, Masanori Kameoka, Nasronudin
    INTRODUCTION: Despite the widespread use of pre-exposure prophylaxis (PrEP) in preventing human immunodeficiency virus (HIV) transmission, scant information on HIV drug resistance mutations (DRMs) has been gathered over the past decade. This review aimed to estimate the pooled prevalence of pre-exposure prophylaxis and its two-way impact on DRM. METHODS: We systematically reviewed studies on DRM in pre-exposure prophylaxis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020 guidelines. PubMed, Cochrane, and SAGE databases were searched for English-language primary studies published between January 2001 and December 2023. The initial search was conducted on 9 August 2021 and was updated through 31 December 2023 to ensure the inclusion of the most recent findings. The registration number for this protocol review was CRD42022356061. RESULTS: A total of 26,367 participants and 562 seroconversion cases across 12 studies were included in this review. The pooled prevalence estimate for all mutations was 6.47% (95% Confidence Interval-CI 3.65-9.93), while Tenofovir Disoproxil Fumarate/Emtricitabine-associated drug resistance mutation prevalence was 1.52% (95% CI 0.23-3.60) in the pre-exposure prophylaxis arm after enrolment. A subgroup analysis, based on the study population, showed the prevalence in the heterosexual and men who have sex with men (MSM) groups was 5.53% (95% CI 2.55-9.40) and 7.47% (95% CI 3.80-12.11), respectively. Notably, there was no significant difference in the incidence of DRM between the pre-exposure prophylaxis and placebo groups (log-OR = 0.99, 95% CI -0.20 to 2.18, I2 = 0%; p = 0.10). DISCUSSION: Given the constrained prevalence of DRM, the World Health Organization (WHO) advocates the extensive adoption of pre-exposure prophylaxis. Our study demonstrated no increased risk of DRM with pre-exposure prophylaxis (p > 0.05), which is consistent with these settings. These findings align with the previous meta-analysis, which reported a 3.14-fold higher risk in the pre-exposure prophylaxis group than the placebo group, although the observed difference did not reach statistical significance (p = 0.21). CONCLUSIONS: Despite the low prevalence of DRM, pre-exposure prophylaxis did not significantly increase the risk of DRM compared to placebo. However, long-term observation is required to determine further disadvantages of extensive pre-exposure prophylaxis use. PROSPERO Number: CRD42022356061.
    2024年06月, AIDS research and therapy, 21(1) (1), 37 - 37, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Siti Qamariyah Khairunisa, Dwi Wahyu Indriati, Ni Luh Ayu Megasari, Shuhei Ueda, Tomohiro Kotaki, Muhamad Fahmi, Masahiro Ito, Brian Eka Rachman, Afif Nurul Hidayati, Nasronudin, Masanori Kameoka
    Human immunodeficiency virus type 1 (HIV-1) remains a serious health threat in Indonesia. In particular, the CRF01_AE viruses were the predominant HIV-1 strains in various cities in Indonesia. However, information on the dynamic transmission characteristics and spatial-temporal transmission of HIV-1 CRF01_AE in Indonesia is limited. Therefore, the present study examined the spatial-temporal transmission networks and evolutionary characteristics of HIV-1 CRF01_AE in Indonesia. To clarify the epidemiological connection between CRF01_AE outbreaks in Indonesia and the rest of the world, we performed phylogenetic studies on nearly full genomes of CRF01_AE viruses isolated in Indonesia. Our results showed that five epidemic clades, namely, IDN clades 1-5, of CRF01_AE were found in Indonesia. To determine the potential source and mode of transmission of CRF01_AE, we performed Bayesian analysis and built maximum clade credibility trees for each clade. Our study revealed that CRF01_AE viruses were commonly introduced into Indonesia from Southeast Asia, particularly Thailand. The CRF01_AE viruses might have spread through major pandemics in Asian countries, such as China, Vietnam, and Laos, rather than being introduced directly from Africa in the early 1980s. This study has major implications for public health practice and policy development in Indonesia. The contributions of this study include understanding the dynamics of HIV-1 transmission that is important for the implementation of HIV disease control and prevention strategies in Indonesia.
    2024年05月, Scientific reports, 14(1) (1), 9917 - 9917, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • TAKUYA TADA, Zhang Yanzhao, kong dechuan, Michiko Tanaka, Weitong YAO, Masanori Kameoka, Takamasa Ueno, Hideaki Fujita, Kenzo Tokunaga
    2024年04月, Cells, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Genotypic Analysis of Transmitted and Acquired HIV Drug Resistance in People Living with HIV/AIDS in Surabaya, Indonesia, from 2018 to 2019
    Brian Eka Rachman, Ni Luh Ayu Megasari, Siti Q. Khairunisa, Tomohiro Kotaki, M. Vitanata Arfijanto, Usman Hadi, Nasronudin, Masanori Kameoka
    2024年04月, Acta Medica Indonesiana, 56(2) (2), 168 - 175
    [査読有り]
    研究論文（学術雑誌）

  • Shunta Takazawa, Tomohiro Kotaki, Satsuki Nakamura, Chie Utsubo, Masanori Kameoka
    The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has necessitated the global development of countermeasures since its outbreak. However, current therapeutics and vaccines to stop the pandemic are insufficient and this is mainly because of the emergence of resistant variants, which requires the urgent development of new countermeasures, such as antiviral drugs. Replicons, self-replicating RNAs that do not produce virions, are a promising system for this purpose because they safely recreate viral replication, enabling antiviral screening in biosafety level (BSL)-2 facilities. We herein constructed three pCC2Fos-based RNA replicons lacking some open reading frames (ORF) of SARS-CoV-2: the Δorf2-8, Δorf2.4, and Δorf2 replicons, and validated their replication in Huh-7 cells. The functionalities of the Δorf2-8 and Δorf2.4 replicons for antiviral drug screening were also confirmed. We conducted puromycin selection following the construction of the Δorf2.4-puro replicon by inserting a puromycin-resistant gene into the Δorf2.4 replicon. We observed the more sustained replication of the Δorf2.4-puro replicon by puromycin pressure. The present results will contribute to the establishment of a safe and useful replicon system for analyzing SARS-CoV-2 replication mechanisms as well as the development of novel antiviral drugs in BSL-2 facilities.
    2023年07月, Virus research, 334, 199176 - 199176, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Chie Aoki-Utsubo, Puguh Indrasetiawan, Kento Fukano, Masamichi Muramatsu, Nina Artanti, Muhammad Hanafi, Hak Hotta, Masanori Kameoka
    Hepatitis B virus (HBV) is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Current therapeutic drugs for chronic HBV infection use IFN and nucleos(t)ide analogs; however, their efficacy is limited. Thus, there is an urgent need to develop new antivirals for HBV therapy. In this study, we identified a plant-derived polyphenolic bioflavonoid, amentoflavone, as a new anti-HBV compound. Amentoflavone treatment dose-dependently inhibited HBV infection in HBV-susceptible cells with HepG2-hNTCP-C4 and primary human hepatocyte PXB-cells. A mode-of-action study showed that amentoflavone inhibits the viral entry step, but not the viral internalization and early replication processes. Attachment of HBV particles as well as HBV preS1 peptide to HepG2-hNTCP-C4 cells was inhibited by amentoflavone. The transporter assay revealed that amentoflavone partly inhibits uptake of sodium taurocholate cotransporting polypeptide (NTCP)-mediated bile acid. Furthermore, effect of various amentoflavone analogs on HBs and HBe production from HBV-infected HepG2-hNTCP-C4 cells was examined. Robustaflavone exhibited comparable anti-HBV activity to that of amentoflavone and an amentoflavone-7,4', 4‴-trimethyl ether derivative (sciadopitysin) with moderate anti-HBV activity. Cupressuflavone or the monomeric flavonoid apigenin did not exhibit the antiviral activity. Amentoflavone and its structurally related biflavonoids may provide a potential drug scaffold in the design of a new anti-HBV drug inhibitor targeting NTCP.
    2023年06月, Microbiology and immunology, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Sri Masyeni, Anak Agung Gede Budhitresna, Randy Adiwinata, Surya Wibawa, Putu Arya Nugraha, Jarwa Antara, Dewa Putu Gede Wedha Asmara, Putu Dyah Widyaningsih, Luh Gede Sri Yenny, Made Widiastika, Siska Kahari, Clareza Arief Wardhana, Arya Widiyana Pasek, Oka Putrawan, Agus Santosa, Sianny Herawati, Nih Luh Putu Eka Arisanti, Wining Astini, Rois Muqsith Fatawy, Masanori Kameoka, Erni Juwita Nelwan
    BACKGROUND: Biomarkers that are cost-effective and accurate for predicting severe coronavirus disease 2019 (COVID-19) are urgently needed. We would like to assess the role of various inflammatory biomarkers on admission as disease severity predictors and determine the optimal cut-off of the neutrophile-to-lymphocyte ratio (NLR) for predicting severe COVID-19. METHODS: We conducted a cross-sectional study in six hospitals in Bali and recruited real-time PCR-confirmed COVID-19 patients aged >18 y from June to August 2020. Data collection included each patient's demographic, clinical, disease severity and hematological data. Multivariate and receiver operating characteristic curve analyses were performed. RESULTS: A total of 95 Indonesian COVID-19 patients were included. The highest NLR among severe patients was 11.5±6.2, followed by the non-severe group at 3.3±2.8. The lowest NLR was found in the asymptomatic group (1.9±1.1). The CD4+ and CD8+ values were lowest in the critical and severe disease groups. The area under the curve of NLR was 0.959. Therefore, the optimal NLR cut-off value for predicting severe COVID-19 was ≥3.55, with sensitivity at 90.9% and a specificity of 16.7%. CONCLUSIONS: Lower CD4+ and CD8+ and higher NLR values on admission are reliable predictors of severe COVID-19 among Indonesian people. NLR cut-off ≥3.55 is the optimal value for predicting severe COVID-19.
    2023年04月, Transactions of the Royal Society of Tropical Medicine and Hygiene, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Viability and acceptability of self-sampling as a primary screening method for sexually transmitted infections in female Kobe University students.
    Yara Priscilla Bule, Yurie Nagai, Masanori Kameoka
    2023年03月, Bulletin of Health Sciences Kobe, 38, 29 - 43, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Siti Qamariyah Khairunisa, Ni Luh Ayu Megasari, Shuhei Ueda, Tomohiro Kotaki, Afif Nurul Hidayati, - Nasronudin, Masanori Kameoka
    Human immunodeficiency virus type 1 (HIV-1) is characterized by a large degree of genetic variability because of high rates of recombination and mutation, sizable population sizes, and rapid replication. Therefore, the present study investigated HIV-1 subtype distribution and the appearance of drug resistance mutations (DRMs) in viruses that are prevalent in Makassar, South Sulawesi, Indonesia. The HIV-1 pol, env, and gag genes were amplified from 63 infected individuals and sequenced for a subtyping analysis. CRF01_AE was identified as the predominant HIV-1 circulating recombinant form (CRF) in Makassar, South Sulawesi, Indonesia. Subtype B and recombinant viruses containing CRF01_AE, CRF02_AG, and/or subtype B gene fragments were also detected. Several major DRMs against non-nucleoside reverse transcriptase inhibitors were found among antiretroviral therapy (ART)-experienced subjects, while ART-naive subjects did not possess any transmitted drug resistance. The prevalence of DRMs was very high among ART-experienced subjects; therefore, further surveillance is required in this region.
    2023年01月, AIDS research and human retroviruses, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Chie Aoki-Utsubo, Muhammad Hanafi, Destia Tri Armanti, Hiroyuki Fuchino, Nobuo Kawahara, Sri Hartati, Aty Widyawaruyanti, Pratiwi Sudarmono, Masanori Kameoka, Hak Hotta
    Chronic hepatitis C virus (HCV) infection can lead to liver cirrhosis and hepatocellular carcinoma. Although current medications using direct-acting antivirals (DAAs) are highly effective and well-tolerated for treating patients with chronic HCV, high prices and the existence of DAA-resistant variants hamper treatment. There is thus a need for easily accessible antivirals with different mechanisms of action. During the screening of Indonesian medicinal plants for anti-HCV activity, we found that a crude extract of Dryobalanops aromatica leaves possessed strong antiviral activity against HCV. Bioassay-guided purification identified an oligostilbene, vaticanol B, as an active compound responsible for the anti-HCV activity. Vaticanol B inhibited HCV infection in a dose-dependent manner with 50% effective and cytotoxic concentrations of 3.6 and 559.5 µg/mL, respectively (Selectivity Index: 155.4). A time-of-addition study revealed that the infectivity of HCV virions was largely lost upon vaticanol B pretreatment. Also, the addition of vaticanol B following viral entry slightly but significantly suppressed HCV replication and HCV protein expression in HCV-infected and a subgenomic HCV replicon cells. Thus, the results clearly demonstrated that vaticanol B acted mainly on the viral entry step, while acting weakly on the post-entry step as well. Furthermore, co-treatment of the HCV NS5A inhibitor daclatasvir with vaticanol B increased the anti-HCV effect. Collectively, the present study has identified a plant-derived oligostilbene, vaticanol B, as a novel anti-HCV compound.
    2023年, Biological & pharmaceutical bulletin, 46(8) (8), 1079 - 1087, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Tomohiro Kotaki, Yurie Nagai, Atsushi Yamanaka, Eiji Konishi, Masanori Kameoka
    Infection with viruses belonging to the genus Flavivirus, such as Japanese encephalitis virus (JEV) and dengue virus (DENV), is a worldwide health problem. Vaccines against JEV and DENV are currently available. However, the dengue vaccine possibly increases the risk of severe dengue due to antibody-dependent enhancement (ADE). Moreover, the Japanese encephalitis (JE) vaccine reportedly induces cross-reactive ADE-prone antibodies against DENV, potentially leading to symptomatic dengue. Therefore, it is necessary to eliminate the risk of ADE through vaccination. In this study, we attempted to develop a JE vaccine that does not induce ADE of DENV infection using an epitope modification strategy. We found that an ADE-prone monoclonal antibody cross-reactive to DENV and JEV recognizes the 106th amino acid residue of the E protein of JEV (E-106). The JE DNA vaccine with a mutation at E-106 (E-106 vaccine) induced comparable neutralizing antibody titers against JEV to those induced by the wild-type JE DNA vaccine. Meanwhile, the E-106 vaccine induced 64-fold less cross-reactive ADE-prone antibodies against DENV. The mutation did not compromise the protective efficacy of the vaccine in the lethal JEV challenge experiment. Altogether, the modification of a single amino acid residue identified in this study helped in the development of an ADE-free JE vaccine.
    2022年08月, Vaccines, 10(9) (9), 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Minori Takaichi, Kayo Osawa, Ryohei Nomoto, Noriko Nakanishi, Masanori Kameoka, Makiko Miura, Katsumi Shigemura, Shohiro Kinoshita, Koichi Kitagawa, Atsushi Uda, Takayuki Miyara, Ni Made Mertaniasih, Usman Hadi, Dadik Raharjo, Ratna Yulistiani, Masato Fujisawa, Kuntaman Kuntaman, Toshiro Shirakawa
    The increase in antibiotic resistance in non-typhoidal Salmonella enterica (NTS) has been confirmed in Indonesia by this study. We confirmed the virulence genes and antimicrobial susceptibilities of clinical NTS (n = 50) isolated from chicken meat in Indonesia and also detected antimicrobial resistance genes. Of 50 strains, 30 (60%) were non-susceptible to nalidixic acid (NA) and all of them had amino acid mutations in gyrA. Among 27 tetracycline (TC) non-susceptible strains, 22 (81.5%) had tetA and/or tetB. The non-susceptibility rates to ampicillin, gentamicin or kanamycin were lower than that of NA or TC, but the prevalence of blaTEM or aadA was high. Non-susceptible strains showed a high prevalence of virulence genes compared with the susceptible strains (tcfA, p = 0.014; cdtB, p < 0.001; sfbA, p < 0.001; fimA, p = 0.002). S. Schwarzengrund was the most prevalent serotype (23 strains, 46%) and the most frequently detected as multi-antimicrobial resistant. The prevalence of virulence genes in S. Schwarzengrund was significantly higher than other serotypes in hlyE (p = 0.011) and phoP/Q (p = 0.011) in addition to the genes above. In conclusion, NTS strains isolated from Indonesian chicken had a high resistance to antibiotics and many virulence factors. In particular, S. Schwarzengrund strains were most frequently detected as multi-antimicrobial resistant and had a high prevalence of virulence genes.
    2022年05月, Pathogens (Basel, Switzerland), 11(5) (5), 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Yanzhao Zhang, Seiya Ozono, Takuya Tada, Minoru Tobiume, Masanori Kameoka, Satoshi Kishigami, Hideaki Fujita, Kenzo Tokunaga
    The host transmembrane protein MARCH8 is a RING finger E3 ubiquitin ligase that downregulates various host transmembrane proteins, such as MHC-II. We have recently reported that MARCH8 expression in virus-producing cells impairs viral infectivity by reducing virion incorporation of not only HIV-1 envelope glycoprotein but also vesicular stomatitis virus G-glycoprotein through two different pathways. However, the MARCH8 inhibition spectrum remains largely unknown. Here, we show the antiviral spectrum of MARCH8 using viruses pseudotyped with a variety of viral envelope glycoproteins. Infection experiments revealed that viral envelope glycoproteins derived from the rhabdovirus, arenavirus, coronavirus, and togavirus (alphavirus) families were sensitive to MARCH8-mediated inhibition. Lysine mutations at the cytoplasmic tails of rabies virus-G, lymphocytic choriomeningitis virus glycoproteins, SARS-CoV and SARS-CoV-2 spike proteins, and Chikungunya virus and Ross River virus E2 proteins conferred resistance to MARCH8. Immunofluorescence showed impaired downregulation of the mutants of these viral envelope glycoproteins by MARCH8, followed by lysosomal degradation, suggesting that MARCH8-mediated ubiquitination leads to intracellular degradation of these envelopes. Indeed, rabies virus-G and Chikungunya virus E2 proteins proved to be clearly ubiquitinated. We conclude that MARCH8 has inhibitory activity on a variety of viral envelope glycoproteins whose cytoplasmic lysine residues are targeted by this antiviral factor. IMPORTANCE A member of the MARCH E3 ubiquitin ligase family, MARCH8, downregulates many different kinds of host transmembrane proteins, resulting in the regulation of cellular homeostasis. On the other hands, MARCH8 acts as an antiviral factor when it binds to and downregulates HIV-1 envelope glycoprotein and vesicular stomatitis virus G-glycoprotein that are viral transmembrane proteins. This study reveals that, as in the case of cellular membrane proteins, MARCH8 shows broad-spectrum inhibition against various viral envelope glycoproteins by recognizing their cytoplasmic lysine residues, resulting in lysosomal degradation.
    2022年02月, Microbiology spectrum, 10(1) (1), e0061821, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Akina Nakamura, Tomohiro Kotaki, Yurie Nagai, Shunta Takazawa, Kenzo Tokunaga, Masanori Kameoka
    The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global threat. To forestall the pandemic, developing safe and effective vaccines is necessary. Because of the rapid production and little effect on the host genome, mRNA vaccines are attractive, but they have a relatively low immune response after a single dose. Replicon RNA (repRNA) is a promising vaccine platform for safety and efficacy. RepRNA vaccine encodes not only antigen genes but also the genes necessary for RNA replication. Thus, repRNA is self-replicative and can play the role of an adjuvant by itself, which elicits robust immunity. This study constructed and evaluated a repRNA vaccine in which the gene encoding the spike (S) protein of SARS-CoV-2 was inserted into a replicon of yellow fever virus 17D strain. Upon electroporation of this repRNA into baby hamster kidney cells, the S protein and yellow fever virus protein were co-expressed. Additionally, the self-replication ability of repRNA vaccine was confirmed using qRT-PCR, demonstrating its potency as a vaccine. Immunization of C57BL/6 mice with 1 μg of the repRNA vaccine induced specific T-cell responses but not antibody responses. Notably, the T-cell response induced by the repRNA vaccine was significantly higher than that induced by the nonreplicative RNA vaccine in our experimental model. In the future, it is of the essence to optimize vaccine administration methods and improve S protein expression, like protection of repRNA by nanoparticles and evasion of innate immunity of the host to enhance the immune-inducing ability of the repRNA vaccine.
    2022年, PloS one, 17(10) (10), e0274829, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Masahiro Urushidani, Akira Kawayoshi, Tomohiro Kotaki, Keiichi Saeki, Yasuko Mori, Masanori Kameoka
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is transmitted mainly by droplet or aerosol infection; however, it may also be transmitted by contact infection. SARS-CoV-2 that adheres to environmental surfaces remains infectious for several days. We herein attempted to inactivate SARS-CoV-2 and influenza A virus adhering to an environmental surface by dry fogging hypochlorous acid solution and hydrogen peroxide solution. SARS-CoV-2 and influenza virus were air-dried on plastic plates and placed into a test chamber for inactivation by the dry fogging of these disinfectants. The results obtained showed that the dry fogging of hypochlorous acid solution and hydrogen peroxide solution inactivated SARS-CoV-2 and influenza A virus in CT value (the product of the disinfectant concentration and contact time)-dependent manners. SARS-CoV-2 was more resistant to the virucidal effects of aerosolized hypochlorous acid solution and hydrogen peroxide solution than influenza A virus; therefore, higher concentrations of disinfectants or longer contact times were required to inactivate SARS-CoV-2 than influenza A virus. The present results provide important information for the development of a strategy that inactivates SARS-CoV-2 and influenza A virus on environmental surfaces by spatial fogging.
    2022年, PloS one, 17(4) (4), e0261802, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Masahiro Urushidani, Akira Kawayoshi, Tomohiro Kotaki, Keiichi Saeki, Yasuko Mori, Masanori Kameoka
    2021年12月

  • Tomohiro Kotaki, Takeshi Kurosu, Ariadna Grinyo-Escuer, Edgar Davidson, Siti Churrotin, Tamaki Okabayashi, Orapim Puiprom, Kris Cahyo Mulyatno, Teguh Hari Sucipto, Benjamin J Doranz, Ken-Ichiro Ono, Soegeng Soegijanto, Masanori Kameoka
    Dengue virus (DENV), from the genus flavivirus of the family flaviviridae, causes serious health problems globally. Human monoclonal antibodies (HuMAb) can be used to elucidate the mechanisms of neutralization and antibody-dependent enhancement (ADE) of DENV infections, leading to the development of a vaccine or therapeutic antibodies. Here, we generated eight HuMAb clones from an Indonesian patient infected with DENV. These HuMAbs exhibited the typical characteristics of weak neutralizing antibodies including high cross-reactivity with other flaviviruses and targeting of the fusion loop epitope (FLE). However, one of the HuMAbs, 3G9, exhibited strong neutralization (NT50 < 0.1 μg/ml) and possessed a high somatic hyper-mutation rate of the variable region, indicating affinity-maturation. Administration of this antibody significantly prolonged the survival of interferon-α/β/γ receptor knockout C57BL/6 mice after a lethal DENV challenge. Additionally, Fc-modified 3G9 that had lost their in vitro ADE activity showed enhanced therapeutic potency in vivo and competed strongly with an ADE-prone antibody in vitro. Taken together, the affinity-matured FLE-targeting antibody 3G9 exhibits promising features for therapeutic application including a low NT50 value, potential for treatment of various kinds of mosquito-borne flavivirus infection, and suppression of ADE. This study demonstrates the therapeutic potency of affinity-matured FLE-targeting antibodies.
    2021年06月, Scientific reports, 11(1) (1), 12987 - 12987, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • インドネシアにおける鶏肉由来のキノロン耐性non-typhoidal Salmonella entericaの遺伝子解析
    高市 果希, 大澤 佳代, 重村 克巳, 北川 孝一, 木下 承晧, 亀岡 正典, 楠木 まり, 宮良 高維, 藤沢 正人, 白川 利朗
    (一社)日本感染症学会, 2021年04月, 感染症学雑誌, 95(臨増) (臨増), 197 - 197, 日本語

  • インドネシアにおけるヒト及び環境由来のESBL産生Escherichia coliの分布調査
    坂本 夏那, 大澤 佳代, 重村 克巳, 北川 孝一, 木下 承晧, 亀岡 正典, 楠木 まり, 宮良 高維, 藤沢 正人, 白川 利朗
    (一社)日本感染症学会, 2021年04月, 感染症学雑誌, 95(臨増) (臨増), 241 - 241, 日本語

  • Tomohiro Kotaki, Atsushi Yamanaka, Eiji Konishi, Masanori Kameoka
    The analysis of neutralizing epitope of dengue virus (DENV) is important for the development of an effective dengue vaccine. A potent neutralizing mouse monoclonal antibody named 7F4 was previously reported and, here, we further analyzed the detailed epitope of this antibody. 7F4 recognized a novel conformational epitope close to the N-67 glycan on the envelope protein. This antibody was specific to the DENV that lacks N-67 glycan, including the Mochizuki strain. Interestingly, the Mochizuki strain acquired N-67 glycan by 7F4 selective pressure. Considering that most of the currently circulating DENVs possess N-67 glycan, DENVs may have evolved to escape from antibodies targeting 7F4 epitope, suggesting the potency of this neutralizing epitope. In addition, this study demonstrated the existence of the epitopes close to 7F4 epitope and their crucial role in neutralization. In conclusion, the epitopes close to the N-67 glycan are attractive targets for the dengue vaccine antigen. Further analysis of this epitope is warranted.
    2021年03月, Virus research, 294, 198278 - 198278, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Tomohiro Kotaki, Xuping Xie, Pei-Yong Shi, Masanori Kameoka
    The development of specific antiviral compounds to SARS-CoV-2 is an urgent task. One of the obstacles for the antiviral development is the requirement of biocontainment because infectious SARS-CoV-2 must be handled in a biosafety level-3 laboratory. Replicon, a non-infectious self-replicative viral RNA, could be a safe and effective tool for antiviral evaluation. Herein, we generated a PCR-based SARS-CoV-2 replicon. Eight fragments covering the entire SARS-CoV-2 genome except S, E, and M genes were amplified with HiBiT-tag sequence by PCR. The amplicons were ligated and in vitro transcribed to RNA. The cells electroporated with the replicon RNA showed more than 3000 times higher luminescence than MOCK control cells at 24 h post-electroporation, indicating robust translation and RNA replication of the replicon. The replication was drastically inhibited by remdesivir, an RNA polymerase inhibitor for SARS-CoV-2. The IC50 of remdesivir in this study was 0.29 μM, generally consistent to the IC50 obtained using infectious SARS-CoV-2 in a previous study (0.77 μM). Taken together, this system could be applied to the safe and effective antiviral evaluation without using infectious SARS-CoV-2. Because this is a PCR-based and transient replicon system, further improvement including the establishment of stable cell line must be achieved.
    2021年01月, Scientific reports, 11(1) (1), 2229 - 2229, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Souichi Nukuzuma, Chiyoko Nukuzuma, Masanori Kameoka, Shigeki Sugiura, Kazuo Nakamichi, Takafumi Tasaki, Koushi Hidaka, Tsutomu Takegami
    JC polyomavirus (JCPyV) causes progressive multifocal leukoencephalopathy (PML), a demyelinating disease of the central nervous system affecting immunocompromised patients. The study of PML-type JCPyV in vitro has been limited owing to the inefficient propagation of the virus in cultured cells. In this study, we carried out long-term culture of COS-7 cells (designated as COS-IMRb cells) transfected with PML-type M1-IMRb, an adapted viral DNA with a rearranged non-coding control region (NCCR). The JCPyV derived from COS-IMRb cells were characterized by analyzing the viral replication, amount of virus by hemagglutination (HA), production of viral protein 1 (VP1), and structure of the NCCR. HA assays indicated the presence of high amounts of PML-type JCPyV in COS-IMRb cells. Immunostaining showed only a small population of JCPyV carrying COS-IMRb cells to be VP1-positive. Sequencing analysis of the NCCR of JCPyV after long-term culture revealed that the NCCR of M1-IMRb was conserved in COS-IMRb cells without any point mutation. The JCPyV genomic DNA derived from a clone of COS-IMRb-3 cells was detected, via Southern blotting, as a single band of approximately 5.1 kbp without deletion. These findings suggest the potential of using COS-IMRb-3 cells as a useful tool for screening anti-JCPyV drugs.
    2021年01月, Japanese journal of infectious diseases, 74(1) (1), 48 - 53, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Siti Qamariyah Khairunisa, Ni Luh Ayu Megasari, Shuhei Ueda, Waras Budiman, Tomohiro Kotaki, Nasronudin, Masanori Kameoka
    The HIV type 1 (HIV-1) epidemic has continued to grow in Indonesia; however, continuous updates on the epidemiology of HIV-1 in Indonesia remain challenging because it is the biggest archipelago in the world. Furthermore, the emergence of HIV drug resistance (HIVDR) has had a negative impact on the treatment of infected individuals. In this study, we performed HIV-1 subtyping and the detection of HIVDR in 105 HIV-1-infected individuals residing in various cities in Indonesia during 2018-2019. The results obtained identified CRF01_AE as the major epidemic HIV-1 strain, responsible for 81.9% of infection cases, followed by subtype B (12.4%), CRF02_AG (3.8%), CRF52_01B (1%), and a recombinant between CRF01_AE and CRF02_AG (1.0%). Major drug resistance-associated mutations against reverse transcriptase inhibitors were detected in 20% of samples. These results suggest that CRF01_AE is a major HIV-1 strain in Indonesia, while CRF02_AG is emerging. The prevalence of HIVDR in Indonesia needs to be monitored.
    2020年11月, AIDS research and human retroviruses, 36(11) (11), 957 - 963, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Youdiil Ophinni, Sayaka Miki, Yoshitake Hayashi, Masanori Kameoka
    HIV-1 cure strategy by means of proviral knock-out using CRISPR-Cas9 has been hampered by the emergence of viral resistance against the targeting guide RNA (gRNA). Here, we proposed multiple, concentrated gRNA attacks against HIV-1 regulatory genes to block viral escape. The T cell line were transduced with single and multiple gRNAs targeting HIV-1 tat and rev using lentiviral-based CRISPR-Cas9, followed by replicative HIV-1NL4-3 challenge in vitro. Viral p24 rebound was observed for almost all gRNAs, but multiplexing three tat-targeting gRNAs maintained p24 suppression and cell viability, indicating the inhibition of viral escape. Multiplexed tat gRNAs inhibited acute viral replication in the 2nd round of infection, abolished cell-associated transmission to unprotected T cells, and maintained protection through 45 days, post-infection (dpi) after a higher dose of HIV-1 infection. Finally, we describe here for the first time the assembly of all-in-one lentiviral vectors containing three and six gRNAs targeting tat and rev. A single-vector tat-targeting construct shows non-inferiority to the tat-targeting multi-vector in low-dose HIV-1 infection. We conclude that Cas9-induced, DNA repair-mediated mutations in tat are sufficiently deleterious and deplete HIV-1 fitness, and multiplexed disruption of tat further limits the possibility of an escape mutant arising, thus elevating the potential of CRISPR-Cas9 to achieve a long-term HIV-1 cure.
    2020年10月, Viruses, 12(11) (11), 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • The Dominance of CRF01_AE and the Emergence of Drug Resistance Mutations Among Antiretroviral Therapy-Experienced, HIV-1-infected Individuals in Medan, Indonesia.
    Dwi Wahyu Indriati, Adiana Mutamsari Witaningrum, M Qushai Yunifiar, Siti Qamariyah Khairunisa, Shuhei Ueda, Tomohiro Kotaki, Nasronudin Nasronudin, Masanori Kameoka
    BACKGROUND: human immunodeficiency virus type 1 (HIV-1) infection is a serious public health threat worldwide. Medan is one example of big cities in Indonesia with a high prevalence of HIV-1 infection; however, quite a limited study had conducted for detecting the circulation of HIV-1 subtypes in Medan. In addition, a serious factor that can implicate the treatment of HIV-1-infected individuals is the emergence of drug resistance mutations. Thus, the information on HIV-1 infection is important to improve the treatment for infected individuals. METHODS: sixty-seven antiretroviral therapy-experienced, HIV-1-infected individuals were recruited for this study. HIV-1 pol genes encoding protease (PR genes) and reverse transcriptase (RT gene), as well as env and gag genes, were amplified from DNA derived from peripheral blood samples. HIV-1 subtyping was conducted to study the dominant HIV-1 subtype circulating in the region. In addition, the emergence of drug resistance mutations was analyzed based on the guidelines published by the International Antiviral Society-United States of America (IAS-USA). RESULTS: the dominant HIV-1 subtype found in Medan was CRF01_AE (77.6%). In addition, another subtype and recombinant viruses such as recombinants between CRF01_AE and subtype B (12.2%), subtype B (4.1%), and CRF02_AG (4.1%) were also found. Drug resistance-associated major mutations were found in 21.6% (8/37) of RT genes and 3.1% (1/32) of PR genes studied. CONCLUSION: our study showed that the dominant subtype found in ART-experienced, HIV-1-infected individuals residing in Medan was CRF01_AE. The emergence of drug resistance mutations in RT and PR genes indicated the importance to monitor the prevalence of drug resistance mutations among HIV-1-infected individuals in Medan.
    2020年10月, Acta medica Indonesiana, 52(4) (4), 366 - 374, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Siti Qamariyah Khairunisa, Ni Luh Ayu Megasari, Dwi Wahyu Indriati, Tomohiro Kotaki, Diana Natalia, Nasronudin, Masanori Kameoka
    Introduction: The present study investigated the HIV-1 subtype classification in addition to prevalence of drug resistance mutations (DRMs) in antiretroviral therapy (ART)-experienced and ART-naïve residents of Pontianak, West Kalimantan, Indonesia. Methods: Whole blood samples collected from 30 HIV-1-infected individuals, comprising 19 ART-experienced and 11 ART-naïve individuals, were subjected to RNA and DNA extraction, followed by HIV-1 genes amplification and sequencing analysis. HIV-1 subtyping was classified on viral pol genes encoding reverse transcriptase (RT gene) and protease (PR gene) accompanied by the env and gag genes. DRMs in the RT and PR genes were also analyzed. Results: CRF01_AE was identified as the predominant circulating recombinant form (CRF) of HIV-1 in both ART-experienced and ART-naïve individuals. In addition, CRF02_AG, subtype B, recombinant virus expressing CRF01_AE and subtype B viral genomic fragments, also recombinant virus containing CRF01_AE and CRF02_AG genomic fragments were also identified. Acquired drug resistance (ADR) was identified in 28.5% of ART-experienced individuals, while no transmitted drug resistance was identified in ART-naïve individuals. Conclusions: This study identified CRF01_AE as the most predominant HIV-1 CRF distributing in Pontianak, Indonesia. The prevalence of ADR is considered to be high; thus, further surveillance is needed in this region.
    2020年09月, Germs, 10(4) (4), 174 - 183, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Siti Qamariyah Khairunisa, Ni Luh Ayu Megasari, Retno Pudji Rahayu, Adiana Mutamsari Witaningrum, Shuhei Ueda, Muhammad Qushai Yunifiar M, Dwi Wahyu Indriati, Tomohiro Kotaki, Adria Rusli, Nasronudin, Masanori Kameoka
    The presence of transmitted drug resistance (TDR) in human immunodeficiency virus type 1 (HIV-1) infected individuals naive to antiretroviral therapy, may affect the effectiveness of treatment. Jakarta, the capital city of Indonesia, recorded the highest number of cumulative HIV infection cases in the country. This study aimed to identify on the appearance of TDR, as well as to identify HIV-1 subtypes circulating among treatment-naive individuals in Jakarta. Whole blood samples collected from 43 HIV-1 infected, treatment-naive individuals. Viral subtyping and drug resistance testing were performed on HIV-1 pol genes amplified using nested polymerase chain reaction. CRF01_AE was detected most frequently in Jakarta (73.08%). Drug resistance-related major mutation was not detected in protease fragments of pol gene, but two major mutations, K103N (6.67%) and Y181C (6.67%), were detected in reverse transcriptase fragments of pol gene. Our results suggest that TDR was emerged in Jakarta at a certain extent, thus further surveillance study to monitor the TDR prevalence and circulating HIV-1 subtypes in this region is considered to be necessary.
    2020年07月, Infectious disease reports, 12(Suppl 1) (Suppl 1), 8740 - 8740, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Sasaki M, Kotaki T, Khairunisa SQ, Tachibana S, Ophinni Y, Hayashi Y, Nasronudin, Kameoka M
    To eradicate human immunodeficiency virus type 1 (HIV-1) infection, a comprehensive strategy including preventive vaccine development is needed. Envelope glycoproteins (Env) play a central role in viral infection and are the major targets of humoral immune responses. Therefore, Env is a candidate vaccine antigen, and its characterization is necessary for vaccine development. The characterization of the transmitted/founder (T/F; i.e., recently infected) virus that is responsible for the establishment of infection and induction of primary anti-HIV-1 immune responses is important. We herein established HIV-1 env clones derived from recently infected Indonesian individuals. All env genes were classified into CRF01_AE. The immunological characterization of env clones was performed by neutralization tests using a series of broadly neutralizing antibodies. The present study is the first to immunologically characterize the CRF01_AE T/F virus circulating in Indonesia.
    2019年10月, AIDS research and human retroviruses, 36(3) (3), 242 - 247, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Oka T, Negi BS, Ueda S, Sasaki M, Kotaki T, Kameoka M
    Human immunodeficiency virus type 1 (HIV-1) is a major causative agent of acquired immune deficiency syndrome. Subtype C (HIV-1C) is the most prevalent HIV-1 subtype worldwide. Although it is highly prevalent in Nepal, genotypic information on Nepalese HIV-1C is limited. We herein investigated the origin and dynamics of HIV-1C in Nepal. Nearly full-length sequencing of Nepalese HIV-1C strains and phylogenetic analyses were performed. The results obtained showed that Nepalese HIV-1C is closely related to the Indian and southern African strains and the introduction of HIV-1C into Nepal was estimated to be in the mid-1980s. These results suggest that multiple HIV-1C strains entered Nepal in the mid-1980s, and this was followed by a marked increase in the number of infection cases for the next decade. These results reflect the current transmission dynamics of HIV-1C strains in Nepal and provide valuable information for HIV monitoring and vaccine development.
    2019年09月, AIDS research and human retroviruses, 35(9) (9), 870 - 875, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Ueda S, Witaningrum AM, Khairunisa SQ, Kotaki T, Motomura K, Nasronudin, Kameoka M
    Human immunodeficiency virus type 1 (HIV-1) and acquired immunodeficiency syndrome (AIDS) represent a major public health concern in Indonesia. Although circulating recombinant form (CRF) 01_AE is a predominant subtype in Indonesia, HIV-1 subtype B (HIV-1B) is also widely prevalent. However, the viral genetic evolution, spatial origins, and patterns of transmission of HIV-1B in Indonesia remain unclear. In the present study, we described the evolutionary characteristics and spatial-temporal transmission networks of HIV-1B in Indonesia. To elucidate the epidemiological link between HIV-1B epidemics in Indonesia and those in the remainder of the world, we conducted phylogenetic analyses of HIV-1B strains in Indonesia. Based on the results obtained, at least three epidemic clades [the Indonesia, United States (US), and China clades] of HIV-1B were found to be prevalent in Indonesia. In order to identify the potential source and transmission route of Indonesian HIV-1B strains, we performed Bayesian analyses and constructed Maximum clade credibility trees of each clade. Although some HIV-1B strains in Indonesia were introduced from Thailand, the prevalent HIV-1B strains appeared to have been directly introduced from Europe or America. Indonesian HIV-1B may have spread via the main dispersal of pandemic HIV-1B strains via the US from the Caribbean region rather than being directly introduced from Africa.
    2019年09月, Scientific reports, 9(1) (1), 13986 - 13986, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Megasari NLA, Oktafiani D, Ana EF, Ueda S, Kotaki T, Nasronudin, Soetjipto, Kameoka M
    Bali, the first province to report a case of HIV in 1987, was placed sixth among Indonesian provinces with the highest cumulative number of HIV cases in 2017. As a popular tourist destination, the spread of genetic variants of HIV through international travel may become a cause for concern in Bali. Tourism is mostly concentrated in south Bali; thus, HIV in less popular regions in north Bali, such as Buleleng Regency, may have viral characteristics different from that in south Bali. Forty-three protease (PR), 40 reverse transcriptase (RT), 27 gag, and 23 env genes were sequenced from 48 samples derived from antiretroviral treatment-experienced individuals. Subtyping revealed CRF01_AE as the dominant circulating recombinant form of HIV-1 in north Bali. Although no major mutation was detected in PR genes, several major mutations were identified in 4 out of the 40 RT genes (10%), indicating the emergence of HIV-1 drug resistance in this region.
    2019年08月, AIDS research and human retroviruses, 35(8) (8), 769 - 774, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • The Emergence of HIV-1 Transmitted Drug Resistance Mutations Among Antiretroviral Therapy-naive Individuals in Buleleng, Bali, Indonesia.
    Megasari NLA, Oktafiani D, Fitriana E, Khairunisa SQ, Kotaki T, Ueda S, Nasronudin N, Soetjipto S, Kameoka M
    BACKGROUND: the global scale-up of antiretroviral therapy (ART) is the primary factor contributing to the decline in deaths from acquired immune deficiency syndrome (AIDS)-related illnesses. However, the emergence of transmitted drug resistance (TDR) compromises the effects of ART in treatment-naïve individuals, which may hinder treatment success. The present study aimed to identify the presence of TDR among treatment-naive individuals in Buleleng, Bali, which is currently ranked sixth among Indonesian provinces with the highest cumulative human immunodeficiency virus type 1 (HIV-1) infection cases. METHODS: thirty-nine ART-naive individuals in Buleleng Regency General Hospital were enrolled in the present study. Blood samples from participants were subjected to a genotypic analysis. RESULTS: 28 protease (PR) and 30 reverse transcriptase (RT) genes were successfully amplified and sequenced from 37 samples. HIV-1 subtyping revealed CRF01_AE as the dominant circulating recombinant form in the region. No TDR for PR inhibitors was detected; however, TDR for RT inhibitors was identified in five out of 30 samples (16.7%). CONCLUSION: these results indicate the emergence of TDR among ART-naive individuals in Buleleng, Bali. This issue warrants serious consideration because TDR may hamper treatment success and reduce ART efficacy among newly diagnosed individuals. Continuous surveillance with a larger sample size is necessary to monitor TDR among ART-naive individuals.
    2019年07月, Acta medica Indonesiana, 51(3) (3), 197 - 204, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Comparison of antibody-dependent cellular cytotoxicity activity elicited in recent and chronic hiv-1-infected thai individuals
    Nithinart Chaitaveep, Piraporn Utachee, Sutchana Tabprasit, Thippawan Chuenchitra, Masanori Kameoka
    SEAMEO TROPMED Network, 2019年07月, Southeast Asian Journal of Tropical Medicine and Public Health, 50(4) (4), 651 - 662, 英語
    研究論文（学術雑誌）

  • Y. Ophinni, M. Inoue, T. Kotaki, M. Kameoka, Y. Hayashi
    Elsevier {BV}, 2019年07月, Journal of Virus Eradication, 5, 17 - 18, 英語, 国際誌, 国際共著している
    [査読有り]
    研究論文（学術雑誌）

  • Ueda S, Witaningrum AM, Khairunisa SQ, Kotaki T, Nasronudin, Kameoka M
    Manado, the capital city of North Sulawesi, is a unique region in Indonesia because of its religion. We collected peripheral blood samples from 63 individuals on antiretroviral therapy. The amplification of viral genomic fragments, viral subtyping, detection of HIV drug resistance-associated mutations (DRAMs), and phylogenetic analyses were performed. Viral subtyping revealed that the most prevalent HIV type 1 (HIV-1) subtype/circulating recombinant form (CRF) was CRF01_AE (84.1%), followed by subtype B (6.8%) and recombinants between CRF01_AE and CRF02_AG (4.5%). Although no major DRAMs were present in protease genes, they were detected in reverse transcriptase (RT) genes. Nine of 38 samples (23.7%) had major DRAMs against nucleoside RT inhibitors (NRTIs) and/or non-NRTIs. The results of phylogenetic analyses indicated that CRF01_AE in North Sulawesi is related to that in Bali. Therefore, Bali may play an important role in circulating CRF01_AE in North Sulawesi.
    2019年04月, AIDS research and human retroviruses, 35(4) (4), 407 - 413, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Tōru Kimura, Takuya Suga, Masanori Kameoka, Minoru Ueno, Yuki Inahashi, Hirotaka Matsuo, Masato Iwatsuki, Katsumi Shigemura, Kazuro Shiomi, Yōko Takahashi, Satoshi Ōmura, Takuji Nakashima
    Two new antibiotics, designated virantmycin B (1) and C (2), were isolated from the cultured broth of Streptomyces sp. AM-2504. Compounds 1 and 2 were purified by Diaion HP-20, silica gel, and octadecylsilane chromatography, followed by high-performance liquid chromatography. The chemical structures of the new compounds, 1 and 2, were determined by nuclear magnetic resonance and mass spectrometry, as containing a terahydroquinoline and an indoline, respectively, each also containing a hydroxy cyclopentenone moiety. Both compounds demonstrated weak antimicrobial (both antibacterial and antifungal) activity and compound 1 also showed antiviral activity against the dengue virus, whereas compound 2 exhibited no antiviral properties.
    2019年03月, The Journal of antibiotics, 72(3) (3), 169 - 173, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Antiviral Activity of Cananga odorata Against Hepatitis B
    Indrasetiawan P, Aoki-Utsubo C, Hanafi M, Hartati S, Wahyuni TS, Kameoka M, Hotta H, Hayashi Y
    Chronic hepatitis B virus (HBV) infection can lead to liver cirrhosis and hepatocellular carcinoma. Current therapeutic drugs for chronic hepatitis B using pegylated interferons and nucleos(t)ide analogs have limited efficacy. Therefore, the development of novel and safe antivirals is required. Natural products including medicinal plants produce complex and structurally diverse compounds, some of which offer suitable targets for antiviral screening studies. In the present study, we screened various crude extracts from Indonesian plants for anti-HBV activity by determining their effects on the production of extracellular HBV DNA in Hep38.7-Tet cells and HBV entry onto a HBV-susceptible cell line, HepG2-NTCP, with the following results: (1) In Hep38.7-Tet cells, Cananga odorata exhibited the highest anti-HBV activity with a 50% inhibitory concentration (IC50) of 56.5 µg/ml and 50% cytotoxic concentration (CC50) of 540.2 µg/ml (Selectivity Index: 9.6). (2) The treatment of HepG2-NTCP cells with Cassia fistula, C. odorata, and Melastoma malabathricum at concentrations of 100 µg/ml lowered the levels of HBsAg production to 51.2%, 58.0%, and 40.1%, respectively, compared to untreated controls, and IC50 and CC50 values of C. odorata were 142.9 µg/ml and >400 µg/ml. In conclusion, the C. odorata extract could be a good candidate for the development of anti-HBV drugs.
    2019年, Kobe Journal of Medical Sciences, 65(2) (2), E71 - E79, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • A. M. Witaningrum, S. Q. Khairunisa, S. Ueda, M. Q. Yunifiar, D. W. Indriati, T. Kotaki, A. Rusli, N. Nasronudin, M. Kameoka
    2018年12月, IOP Conference Series: Materials Science and Engineering, 434(1) (1)
    [査読有り]
    研究論文（国際会議プロシーディングス）

  • Youdiil Ophinni, Mari Inoue, Tomohiro Kotaki, Masanori Kameoka
    Nature Publishing Group, 2018年12月, Scientific Reports, 8(1) (1), 7784, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Souichi Nukuzuma, Chiyoko Nukuzuma, Masanori Kameoka, Shigeki Sugiura, Kazuo Nakamichi, Takafumi Tasaki, Koushi Hidaka, Tsutomu Takegami
    JC polyomavirus (JCPyV) is the causative agent of progressive multifocal leukoencephalopathy (PML), a demyelinating disease of the central nervous system in immunocompromised patients. Archetype JCPyV circulates in the human population. There have been several reports of archetype JCPyV replication in cultured cells, in which propagation was not enough to produce high titers of archetype JCPyV. In this study, we carried out cultivation of the transfected cells with archetype JCPyV DNA MY for more than 2 months to establish COS-7 cells (designated COS-JC cells) persistently producing archetype JCPyV. Moreover, JCPyV derived from COS-JC cells was characterized by analyzing the viral propagation, size of the viral genome, amount of viral DNA, production of viral protein, and structure of the non-coding control region (NCCR). Southern blotting using a digoxigenin-labeled JCPyV probe showed two different sizes of the JCPyV genome in COS-JC cells. For molecular cloning, four of five clones showed a decrease in the size of complete JCPyV genome. Especially, clone No. 10 was generated the large deletion within the Large T antigen. On the other hand, the archetype structure of the NCCR was maintained in COS-JC cells, although a few point mutations occurred. Quantitative PCR analysis of viral DNA in COS-JC cells indicated that a high copy number of archetype JCPyV DNA was replicated in COS-JC cells. These findings suggest that COS-JC cells could efficiently propagate archetype JCPyV MY and offer a useful tool to study persistent infection of archetype JCPyV in a kidney-derived system.
    2018年08月, Microbiology and immunology, 62(8) (8), 524 - 530, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Siti Qamariyah Khairunisa, Shuhei Ueda, Adiana Mutamsari Witaningrum, Muhammad Qushai Yunifiar Matondang, Dwi Wahyu Indriati, Tomohiro Kotaki, Nasronudin, Masanori Kameoka
    Mary Ann Liebert Inc., 2018年06月, AIDS Research and Human Retroviruses, 34(6) (6), 555 - 560, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Hidaka K, Kimura T, Sankaranarayanan R, Wang J, McDaniel KF, Kempf DJ, Kameoka M, Adachi M, Kuroki R, Nguyen JT, Hayashi Y, Kiso Y
    2018年06月, Journal of medicinal chemistry, 61(12) (12), 5138 - 5153
    [査読有り]

  • Bharat Singh Negi, Sunil Kumar Joshi, Minato Nakazawa, Tomohiro Kotaki, Anup Bastola, Masanori Kameoka
    Public Library of Science, 2018年06月, PLoS ONE, 13(6) (6), e0198071, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Genotypic characterization of human immunodeficiency virus type 1 isolated in Bali, Indonesia in 2016.
    Khairunisa, S. Q, Masyeni, S, Witaningrum, A. M, Yunifiar, M. M. Q, Indriati, D. W, Kotaki, T, Ueda, S, Budiyasa, D. G, Nasronudin, Kameoka, M
    2018年05月, HIV AIDS Rev, 17(2) (2), 81 - 90, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Kris Cahyo Mulyatno, Tomohiro Kotaki, Subagyo Yotopranoto, Etik Ainun Rohmah, Siti Churotin, Teguh Hari Sucipto, Ilham Harlan Amarullah, Puspa Wardhani, Soegeng Soegijanto, Masanori Kameoka
    National Institute of Health, 2018年, Japanese Journal of Infectious Diseases, 71(1) (1), 58 - 61, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yu-Shi Tian, Yi Zhou, Tatsuya Takagi, Masanori Kameoka, Norihito Kawashita
    Pharmaceutical Society of Japan, 2018年, Chemical and Pharmaceutical Bulletin, 66(3) (3), 191 - 206, 英語
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Teguh Hari Sucipto, Siti Churrotin, Harsasi Setyawati, Fahimah Martak, Kris Cahyo Mulyatno, Ilham Harlan Amarullah, Tomohiro Kotaki, Masanori Kameoka, Subagyo Yotopranoto, Soegeng Soegijanto
    Obafemi Awolowo University, 2018年, African Journal of Infectious Diseases, 12(1) (1), 116 - 119, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Sucipto TH, Kotaki T, Mulyatno KC, Churrotin S, Labiqah A, Soegijanto S, Kameoka M
    Dengue virus (DENV) infection is a major health issue in tropical and subtropical areas. Indonesia is one of the biggest dengue endemic countries in the world. In the present study, the phylogenetic analysis of DENV in Bangkalan, Madura Island, Indonesia, was performed in order to obtain a clearer understanding of its dynamics in this country. A total of 359 blood samples from dengue-suspected patients were collected between 2012 and 2014. Serotyping was conducted using a multiplex Reverse Transcriptase-Polymerase Chain Reaction and a phylogenetic analysis of E gene sequences was performed using the Bayesian Markov chain Monte Carlo (MCMC) method. 17 out of 359 blood samples (4.7%) were positive for the isolation of DENV. Serotyping and the phylogenetic analysis revealed the predominance of DENV-1 genotype I (9/17, 52.9%), followed by DENV-2 Cosmopolitan type (7/17, 41.2%) and DENV-3 genotype I (1/17, 5.9%). DENV-4 was not isolated. The Madura Island isolates showed high nucleotide similarity to other Indonesian isolates, indicating frequent virus circulation in Indonesia. The results of the present study highlight the importance of continuous viral surveillance in dengue endemic areas in order to obtain a clearer understanding of the dynamics of DENV in Indonesia.
    2018年, Journal of tropical medicine, 2018, 8127093 - 8127093, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Indriati DW, Kotaki T, Khairunisa SQ, Witaningrum AM, Matondang MQY, Ueda S, Nasronudin, Purnama A, Kurniawan D, Kameoka M
    BACKGROUND AND OBJECTIVES: Human Immunodeficiency Virus (HIV) is still a major health issue in Indonesia. In recent years, the appearance of drug resistance-associated mutations has reduced the effectiveness of Antiretroviral Therapy (ART). We conducted genotypic studies, including the detection of drug resistance-associated mutations (from first-line regimen drugs), on HIV-1 genes derived from infected individuals in Maumere, West Nusa Tenggara. Maumere, a transit city in West Nusa Tenggara, which has a high HIV-1 transmission rate. METHOD: We collected 60 peripheral blood samples from 53 ART-experienced and 7 ART-naive individuals at TC Hillers Hospital, Maumere between 2014 and 2015. The amplification and a sequencing analysis of pol genes encoding protease (the PR gene) and reverse transcriptase (the RT gene) as well as the viral env and gag genes were performed. HIV-1 subtyping and the detection of drug resistance-associated mutations were then conducted. RESULTS: Among 60 samples, 46 PR, 31 RT, 30 env, and 20 gag genes were successfully sequenced. The dominant HIV-1 subtype circulating in Maumere was CRF01_AE. Subtype B and recombinant viruses containing gene fragments of CRF01_AE, subtypes A, B, C, and/or G were also identified as minor populations. The major drug resistance-associated mutations, M184V, K103N, Y188L, and M230I, were found in the RT genes. However, no major drug resistance-associated mutations were detected in the PR genes. CONCLUSION: CRF01_AE was the major HIV-1 subtype prevalent in Maumere. The appearance of drug resistance-associated mutations found in the present study supports the necessity of monitoring the effectiveness of ART in Maumere.
    2018年, Current HIV research, 16(2) (2), 158 - 166, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Shingo Tachibana, Maho Sasaki, Takako Tanaka, Mari Inoue, Youdiil Ophinni, Tomohiro Kotaki, Masanori Kameoka
    2017年12月, AIDS RESEARCH AND HUMAN RETROVIRUSES, 33(12) (12), 1248 - 1257, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Ming Chen, Chie Aoki-Utsubo, Masanori Kameoka, Lin Deng, Yutaka Terada, Wataru Kamitani, Kei Sato, Yoshio Koyanagi, Makoto Hijikata, Keiko Shindo, Takeshi Noda, Michinori Kohara, Hak Hotta
    2017年11月, SCIENTIFIC REPORTS, 7(1) (1), 15931, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Bharat Singh Negi, Tomohiro Kotaki, Sunil Kumar Joshi, Anup Bastola, Minato Nakazawa, Masanori Kameoka
    2017年09月, AIDS RESEARCH AND HUMAN RETROVIRUSES, 33(9) (9), 960 - 965, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Sero- and Molecular Epidemiology of HIV-1 in Papua Province, Indonesia.
    Masanori Kameoka
    2017年07月, Acta medica Indonesiana, 49(3) (3), 205 - 214
    [査読有り]
    研究論文（学術雑誌）

  • Souichi Nukuzuma, Chiyoko Nukuzuma, Masanori Kameoka, Shigeki Sugiura, Kazuo Nakamichi, Takafumi Tasaki, Tsutomu Takegami
    2017年06月, MICROBIOLOGY AND IMMUNOLOGY, 61(6) (6), 232 - 238, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Souichi Nukuzuma, Chiyoko Nukuzuma, Masanori Kameoka, Shigeki Sugiura, Kazuo Nakamichi, Takafumi Tasaki, Tsutomu Takegami
    JC polyomavirus (JCPyV) is the causative agent of the demyelinating disease of the central nervous system known as progressive multifocal leukoencephalopathy (PML), which occurs in immunocompromised patients. Moreover, patients treated with natalizumab for multiple sclerosis or Crohn disease can develop PML, which is then termed natalizumab-related PML. Because few drugs are currently available for treating PML, many antiviral agents are being investigated. It has been demonstrated that the topoisomerase I inhibitors topotecan and β-lapachone have inhibitory effects on JCPyV replication in IMR-32 cells. However, both of these drugs have marginal inhibitory effects on virus propagation in JC1 cells according to RT-PCR analysis. In the present study, the inhibitory effect of another topoisomerase I inhibitor, 7-ethy-10-[4-(1-piperidino)-1-piperidino] carbonyloxy camptothecin (CPT11), was assessed by investigating viral replication, propagation, and viral protein 1 (VP1) production in cultured cells. JCPyV replication was assayed using real-time PCR combined with Dpn I treatment in IMR-32 cells transfected with JCPyV DNA. It was found that JCPyV replicates less in IMR-32 cells treated with CPT11 than in untreated cells. Moreover, CPT11 treatment of JCI cells persistently infected with JCPyV led to a dose-dependent reduction in JCPyV DNA and VP1 production. Additionally, the inhibitory effect of CPT11 was found to be stronger than those of topotecan and β-lapachone. These findings suggest that CPT11 may be a potential anti-JCPyV agent that could be used to treat PML.
    2017年06月, Microbiology and immunology, 61(6) (6), 232 - 238, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Mari Inoue, Daiki Oyama, Koushi Hidaka, Masanori Kameoka
    2017年01月, FEBS OPEN BIO, 7(1) (1), 88 - 95, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yu-Shi Tian, Norihito Kawashita, Masanori Kameoka, Tatsuya Takagi
    The high impact of the acquired immunodeficiency syndrome caused by human immunodeficiency virus has represented a significant public health threat in the last four decades. Recently, the development of new antiviral drugs
    has led to great progress in overcoming this virus. Antiretroviral therapy coverage has been increasing, even in low-income countries, resulting in an overall decline of HIV/AIDS-related deaths worldwide. Nonetheless, new
    infections still appear, and the era of clearance of this virus has not yet been reached. Moreover, the resistance of the virus to drugs during treatments remains a serious problem.
    Therefore, researchers are actively seeking to discover and characterize new molecule(s) that could be suitable for anti-HIV treatment. Cyclophilin A, a host molecular chaperone or folder protein, is suspected to be one such attractive target. We and others are searching for inhibitor(s) of this molecule and investigating its mechanism of action throughout the viral life cycle. In this review, we focus on studies related to cyclophilin A and the candidate inhibitors.
    iMedPub Journals, 2016年11月, Journal of Prevention & Infection Control, 2(2:12) (2:12), 1 - 5, 英語
    [査読有り]

  • Siti Churrotin, Tomohiro Kotaki, Teguh Hari Sucipto, Nur Laila Fitriati Ahwanah, Pemta Tia Deka, Kris Cahyo Mulyatno, Dwi Ambar Prihatining Utami, Raafqi Ranasasmita, Soegeng Soegijanto, Masanori Kameoka
    2016年09月, JAPANESE JOURNAL OF INFECTIOUS DISEASES, 69(5) (5), 442 - 444, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Adiana Mutamsari Witaningrum, Tomohiro Kotaki, Siti Qamariyah Khairunisa, Muhammad Qushai M. Yunifiar, Dwi Wahyu Indriati, Rendra Bramanthi, Nasronudin, Masanori Kameoka
    2016年08月, AIDS RESEARCH AND HUMAN RETROVIRUSES, 32(8) (8), 812 - 817, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Nithinart Chaitaveep, Piraporn Utachee, Thippawan Chuenchitra, Nicos Karasavvan, Naokazu Takeda, Masanori Kameoka
    2016年05月, MICROBES AND INFECTION, 18(5) (5), 346 - 353, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Atsushi Yamanaka, Duangjai Oddgun, Nantarat Chantawat, Tamaki Okabayashi, Pongrama Ramasoota, Siti Churrotin, Tomohiro Kotaki, Masanori Kameoka, Soegeng Soegijanto, Eiji Konishi
    2016年04月, MICROBES AND INFECTION, 18(4) (4), 277 - 284, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Souichi Nukuzuma, Kazuo Nakamichi, Masanori Kameoka, Shigeki Sugiura, Chiyoko Nukuzuma, Takafumi Tasaki, Tsutomu Takegami
    2016年04月, MICROBIOLOGY AND IMMUNOLOGY, 60(4) (4), 253 - 260, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tomohiro Kotaki, Atsushi Yamanaka, Kris Cahyo Mulyatno, Siti Churrotin, Teguh Hari Sucipto, Amaliah Labiqah, Nur Laila Fitriati Ahwanah, Soegeng Soegijanto, Masanori Kameoka, Eiji Konishi
    2016年01月, INFECTION GENETICS AND EVOLUTION, 37, 88 - 93, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M. Z. Fahmi, W. Sukmayani, Siti Qamariyah Khairunisa, A. M. Witaningrum, D. W. Indriati, M. Q. Y. Matondang, J. -Y. Chang, T. Kotaki, M. Kameoka
    2016年, RSC ADVANCES, 6(95) (95), 92996 - 93002, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Teguh Hari Sucipto, Amaliah Labiqah, Siti Churrotin, Nur Ahwanah, Kris Cahyo Mulyatno, Soegeng Soegijanto, Tomohiro Kotaki, Masanori Kameoka, Eiji Konishi
    Universitas Airlangga, 2015年07月, Indonesian Journal of Tropical and Infectious Disease, 5(1) (1), 1 - 1
    研究論文（学術雑誌）

  • Chris Verathamjamras, Yu-Shi Tian, Norihito Kawashita, Kousuke Okamoto, Teruo Yasunaga, Kazuyoshi Ikuta, Kazushi Motomura, Naokazu Takeda, Tatsuya Takagi, Masanori Kameoka
    {OMICS} Publishing Group, 2015年05月, J. Infect. Dis. Ther., 3(3) (3), 1 - 8, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Souichi Nukuzuma, Shigeki Sugiura, Kazuo Nakamichi, Masanori Kameoka, Chiyoko Nukuzuma, Takafumi Tasaki, Tsutomu Takegami
    2015年04月, MICROBIOLOGY AND IMMUNOLOGY, 59(4) (4), 238 - 242, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Siti Qamariyah Khairunisa, Tomohiro Kotaki, Adiana Mutamsari Witaningrum, Muhammad Qushai Yunifiar M, Septhia Dwi Sukartiningrum, Nasronudin, Masanori Kameoka
    2015年02月, AIDS RESEARCH AND HUMAN RETROVIRUSES, 31(2) (2), 255 - 259, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Kotaki T, Khairunisa SQ, Witaningrum AM, M MQY, Sukartiningrum SD, Diansyah MN, Rahayu RP, Nasronudin ᅟ, Kameoka M
    2015年02月, AIDS research and therapy, 12, 5, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Nukuzuma S, Nakamichi K, Kameoka M, Sugiura S, Nukuzuma C, Tasaki T, Takegami T
    2014年12月, Journal of medical virology, 86(12) (12), 2026 - 2032, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tomohiro Kotaki, Atsushi Yamanaka, Kris Cahyo Mulyatno, Siti Churrotin, Amaliah Labiqah, Teguh Hari Sucipto, Soegeng Soegijanto, Masanori Kameoka, Eiji Konishi
    2014年12月, INFECTION GENETICS AND EVOLUTION, 28, 48 - 54, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tomohiro Kotaki, Siti Qamariyah Khairunisa, Septhia Dwi Sukartiningrum, Adiana Mutamsari Witaningrum, Musofa Rusli, M. Noor Diansyah, M. Vitanata Arfijanto, Retno Pudji Rahayu, Nasronudin, Masanori Kameoka
    2014年05月, AIDS RESEARCH AND HUMAN RETROVIRUSES, 30(5) (5), 489 - 492, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Phylogenetic Analysis of Dengue Virus Type 3 Strains Primarily Isolated in 2013 from Surabaya, Indonesia
    Tomohiro Kotaki, Atsushi Yamanaka, Kris Cahyo Mulyatno, Amaliah Labiqah, Teguh Hari Sucipto, Siti Churrotin, Soegeng Soegijanto, Eiji Konishi, Masanori Kameoka
    2014年05月, JAPANESE JOURNAL OF INFECTIOUS DISEASES, 67(3) (3), 227 - 229, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Piraporn Utachee, Panasda Isarangkura-na-Ayuthaya, Kenzo Tokunaga, Kazuyoshi Ikuta, Naokazu Takeda, Masanori Kameoka
    2014年04月, RETROVIROLOGY, 11, 32, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Fithriyah Sjatha, Miwa Kuwahara, T. Mirawati Sudiro, Masanori Kameoka, Eiji Konishi
    2014年02月, MICROBIOLOGY AND IMMUNOLOGY, 58(2) (2), 126 - 134, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Nithinart Chaitaveep, Piraporn Utachee, Shota Nakamura, Thippawan Chuenchitra, Pattama Ekpo, Naokazu Takeda, Kovit Pattanapanyasat, Masanori Kameoka
    2014年02月, MICROBES AND INFECTION, 16(2) (2), 142 - 152, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tomohiro Kotaki, Siti Qamariyah Khairunisa, Septhia Dwi Sukartiningrum, M. Vitanata Arfijanto, Takako Utsumi, Irine Normalina, Retno Handajani, Prihartini Widiyanti, Musofa Rusli, Retno Pudji Rahayu, Maria Inge Lusida, Yoshitake Hayashi, Nasronudin, Masanori Kameoka
    2013年12月, PLOS ONE, 8(12) (12), e82645, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Soegeng Soegijanto, Desiana W. Sari, Atsushi Yamanaka, Tomohiro Kotaki, Masanori Kameoka, Eiji Konishi
    Universitas Airlangga, 2013年10月, Indonesian Journal of Tropical and Infectious Disease, 4(4) (4), 35 - 35
    研究論文（学術雑誌）

  • Sompong Sapsutthipas, Naho Tsuchiya, Panita Pathipavanich, Koya Ariyoshi, Pathom Sawanpanyalert, Naokazu Takeda, Panasda Isarangkura-na-ayuthaya, Masanori Kameoka
    2013年01月, PLoS ONE, 8(1) (1), e53920, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yu-Shi Tian, Chris Verathamjamras, Norihito Kawashita, Kousuke Okamoto, Teruo Yasunaga, Kazuyoshi Ikuta, Masanori Kameoka, Tatsuya Takagi
    2013年01月, JOURNAL OF MOLECULAR MODELING, 19(1) (1), 465 - 475, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Souichi Nukuzuma, Masanori Kameoka, Shigeki Sugiura, Kazuo Nakamichi, Chiyoko Nukuzuma, Tsutomu Takegami
    The incidence of progressive multifocal leukoencephalopathy (PML) has increased due to the AIDS pandemic, hematological malignancies, and immunosuppressive therapies. Recently, the number of cases of monoclonal antibody-associated PML has increased in patients treated with immunomodulatory drugs such as natalizumab. However, no common consensus regarding PML therapy has been reached in clinical studies. In order to examine the suppression of JC virus (JCV) replication by 3-aminobenzamide (3-AB), a representative PARP-1 inhibitor, a DNA replication assay was carried out using the neuroblastoma cell line IMR-32 and IMR-adapted JCV. The suppression of JCV propagation by 3-AB was also examined using JCI cells, which are a carrier culture producing continuously high JCV titers. The results indicated that PARP-1 inhibitors, such as 3-aminobenzamide (3-AB), suppress JCV replication and propagation significantly in vitro, as judged by DNA replication assay, hemagglutination, and real-time PCR analysis. It has been also shown that 3-AB reduced PARP-1 activity in IMR-32 cells. According to the results of the MTT assay, the enzyme activity of 3-AB-treated cells was slightly lower than that of DMSO-treated cells. However, the significant suppression of JCV propagation is not related to the slight decrease in cell growth. To our knowledge, this is the first report that PARP-1 inhibitor suppresses the replication of JCV significantly in neuroblastoma cell lines via the reduction of PARP-1 activity. Thus, PARP-1 inhibitors also may be a novel therapeutic drug for PML.
    2013年01月, Journal of medical virology, 85(1) (1), 132 - 7, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Kameoka, M., Sasaki, T.
    2013年, Uirusu, 63(1) (1), 51 - 58
    [査読有り]
    研究論文（学術雑誌）

  • Variables influencing anti-human immunodeficiency virus type 1 neutralizing human monoclonal antibody (NhMAb) production among infected Thais
    Siriwat Akapirat, Anchalee Avihingsanon, Jintanat Ananworanich, Alexandra Schuetz, Pongrama Ramasoota, Natthanej Luplertlop, Ken-Ichiro Ono, Kazuyoshi Ikuta, Piraporn Utachee, Masanori Kameoka, Pornsawan Leaungwutiwong
    SEAMEO TROPMED Network, 2013年, Southeast Asian Journal of Tropical Medicine and Public Health, 44(5) (5), 825 - 841, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yong-Gang Li, Uamporn Siripanyaphinyo, Uranan Tumkosit, Nitchakarn Noranate, Atchareeya A-nuegoonpipat, Yang Pan, Masanori Kameoka, Takeshi Kurosu, Kazuyoshi Ikuta, Naokazu Takeda, Surapee Anantapreecha
    2012年06月, VIROLOGY JOURNAL, 9, 114, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Souichi Nukuzuma, Masanori Kameoka, Shigeki Sugiura, Kazuo Nakamichi, Chiyoko Nukuzuma, Isao Miyoshi, Tsutomu Takegami
    2012年04月, JOURNAL OF MEDICAL VIROLOGY, 84(4) (4), 555 - 561, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Samatchaya Boonchawalit, Duangrat Jullaksorn, Jiraporn Uttiyoung, Amara Yowang, Nongkran Krathong, Sununta Chautrakul, Akifumi Yamashita, Kazuyoshi Ikuta, Amornsak Roobsoong, Sangkom Kanitvittaya, Pathom Sawanpanyalert, Masanori Kameoka
    2011年11月, PLOS ONE, 6(11) (11), e27098, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • VIRAL FACTORS INVOLVED IN ADAPTER-RELATED PROTEIN COMPLEX 2 ALPHA 1 SUBUNIT-MEDIATED REGULATION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REPLICATION
    Sompong Sapsutthipas, Yukiko Kitagawa, Kenzo Tokunaga, Kazuyoshi Ikuta, Masanori Kameoka
    2011年03月, SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH, 42(2) (2), 311 - 319, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Panasda Isarangkura-na-ayuthaya, Wiyada Kaewnoo, Wattana Auwanit, U. Chandimal de Silva, Kazuyoshi Ikuta, Pathom Sawanpanyalert, Masanori Kameoka
    2010年12月, AIDS RESEARCH AND HUMAN RETROVIRUSES, 26(12) (12), 1341 - 1343, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Souichi Nukuzuma, Kazuo Nakamichi, Masanori Kameoka, Shigeki Sugiura, Chiyoko Nukuzuma, Isao Miyoshi, Tsutomu Takegami
    2010年12月, MICROBIOLOGY AND IMMUNOLOGY, 54(12) (12), 758 - 762, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masanori Kameoka, Panasda Isarangkura-na-ayuthaya, Yoko Kameoka, Sompong Sapsutthipas, Bongkot Soonthornsata, Shota Nakamura, Kenzo Tokunaga, Pathom Sawanpanyalert, Kazuyoshi Ikuta, Wattana Auwanit
    2010年09月, VIROLOGY, 405(1) (1), 129 - 138, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Bongkot Soonthornsata, Yu-Shi Tian, Piraporn Utachee, Sompong Sapsutthipas, Panasda Isarangkura-na-ayuthaya, Wattana Auwanit, Tatsuya Takagi, Kazuyoshi Ikuta, Pathom Sawanpanyalert, Norihito Kawashita, Masanori Kameoka
    2010年09月, VIROLOGY, 405(1) (1), 157 - 164, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yong-Gang Li, Malinee Chittaganpitch, Sunthareeya Waicharoen, Yuta Kanai, Gui-Rong Bai, Masanori Kameoka, Naokazu Takeda, Kazuyoshi Ikuta, Pathom Sawanpanyalert
    2010年06月, VIROLOGY JOURNAL, 7, 112, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Piraporn Utachee, Shota Nakamura, Panasda Isarangkura-na-Ayuthaya, Kenzo Tokunaga, Pathom Sawanpanyalert, Kazuyoshi Ikuta, Wattana Auwanit, Masanori Kameoka
    2010年05月, JOURNAL OF VIROLOGY, 84(9) (9), 4311 - 4320, 英語
    [査読有り]
    研究論文（学術雑誌）

  • SUSTAINED APPEARANCE OF DRUG RESISTANCE-ASSOCIATED MUTATIONS IN HIV-1 CRF01_AE PROTEASE AND REVERSE TRANSCRIPTASE DERIVED FROM PROTEASE INHIBITOR-NAIVE THAI PATIENTS
    Duangrat Jullaksorn, Samatchaya Boonchawalit, Jiraporn Uttiyoung, Bongkot Soonthornsata, Amara Yowang, Nongkran Krathong, Sununta Chautrakul, Kazuyoshi Ikuta, Amornsak Roobsoong, Sangkom Kanitvittaya, Pathom Sawanpanyalert, Masanori Kameoka
    2010年03月, SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH, 41(2) (2), 347 - 357, 英語
    [査読有り]
    研究論文（学術雑誌）

  • U. Chandimal de Silva, Jiranan Warachit, Nerisa Sattagowit, Chanin Jirapongwattana, Sumolrat Panthong, Piraporn Utachee, Teruo Yasunaga, Kazuyoshi Ikuta, Masanori Kameoka, Naphatsawan Boonsathorn
    2010年02月, AIDS RESEARCH AND HUMAN RETROVIRUSES, 26(2) (2), 223 - 227, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yaowapa Pongsuwannna, Ratigorn Guntapong, Ratana Tacharoenmuang, Malliga Prapanpoj, Masanori Kameoka, Koki Taniguchi
    2010年01月, JOURNAL OF MEDICAL VIROLOGY, 82(1) (1), 157 - 163, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Souichi Nukuzuma, Masanori Kameoka, Shigeki Sugiura, Kazuo Nakamichi, Chiyoko Nukuzuma, Isao Miyoshi, Tsutomu Takegami
    2009年11月, MICROBIOLOGY AND IMMUNOLOGY, 53(11) (11), 621 - 628, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Uamporn Siripanyaphinyo, Dusit Laohasinnarong, Juthamas Siripanee, Kampon Kaeoket, Masanori Kameoka, Kazuyoshi Ikuta, Pathom Sawanpanyalert
    2009年04月, JOURNAL OF MEDICAL VIROLOGY, 81(4) (4), 657 - 664, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yukie Iwabu, Hiroyuki Mizuta, Michiko Kawase, Masanori Kameoka, Toshiyuki Goto, Kazuyoshi Ikuta
    2008年04月, MICROBES AND INFECTION, 10(5) (5), 504 - 513, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Sanae Shoji-Kawata, Qiu Zhong, Masanori Kameoka, Yukie Iwabu, Sompong Sapsutthipas, Ronald B. Luftig, Kazuyoshi Ikuta
    2007年11月, VIROLOGY, 368(1) (1), 191 - 204, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tat San Lau, Yonggang Li, Masanori Kameoka, Tzi Bun Ng, David Chi Cheong Wan
    2007年07月, FEBS LETTERS, 581(17) (17), 3253 - 3259, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yukie Wabu, Toshiyuki Goto, Shotaro Tsuji, Jiranan Warachit, Gui-Mei Li, Sanae Shoji, Masanori Kameoka, Kazuyoshi Ikuta
    2006年06月, MICROBES AND INFECTION, 8(7) (7), 1773 - 1782, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Y Tanaka, K Ota, M Kameoka, A Itaya, K Yoshihara
    2006年05月, EXPERIMENTAL CELL RESEARCH, 312(8) (8), 1254 - 1264, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M Kameoka, S Nukuzuma, A Itaya, Y Tanaka, K Ota, Y Inada, K Ikuta, K Yoshihara
    2005年08月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 334(2) (2), 412 - 417, 英語
    [査読有り]
    研究論文（学術雑誌）

  • YG Li, Y Iwabu, J Warachit, M Kinomoto, MS Ibrahim, S Tsuji, T Mukai, M Kameoka, K Tokunaga, T Sata, K Ikuta
    2005年, MICROBIOLOGY AND IMMUNOLOGY, 49(2) (2), 155 - 165, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M Kameoka, S Nukuzuma, A Itaya, Y Tanaka, K Ota, K Ikuta, K Yoshihara
    2004年08月, JOURNAL OF VIROLOGY, 78(16) (16), 8931 - 8934, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Y Tanaka, M Kameoka, A Itaya, K Ota, K Yoshihara
    2004年05月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 317(3) (3), 865 - 872, 英語
    [査読有り]
    研究論文（学術雑誌）

  • C Liang, J Hu, RS Russell, M Kameoka, MA Wainberg
    2004年02月, AIDS RESEARCH AND HUMAN RETROVIRUSES, 20(2) (2), 203 - 211, 英語
    [査読有り]
    研究論文（学術雑誌）

  • K Ota, M Kameoka, Y Tanaka, A Itaya, K Yoshihara
    2003年10月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 310(2) (2), 312 - 317, 英語
    [査読有り]
    研究論文（学術雑誌）

  • XF Guo, M Kameoka, Wei, X, B Roques, M Gotte, C Liang, MA Wainberg
    2003年03月, VIROLOGY, 307(1) (1), 154 - 163, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M Kameoka, M Morgan, M Binette, RS Russell, LW Rong, XF Guo, A Mouland, L Kleiman, C Liang, MA Wainberg
    2002年04月, JOURNAL OF VIROLOGY, 76(8) (8), 3637 - 3645, 英語
    [査読有り]
    研究論文（学術雑誌）

  • K Ota, AG Yakovlev, A Itaya, M Kameoka, Y Tanaka, K Yoshihara
    2002年01月, JOURNAL OF BIOCHEMISTRY, 131(1) (1), 131 - 135, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M Kameoka, LW Rong, M Gotte, C Liang, RS Russell, MA Wainberg
    2001年03月, JOURNAL OF VIROLOGY, 75(6) (6), 2675 - 2683, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Matthias Götte, Masanori Kameoka, Nathan McLellan, Luciano Cellai, Mark A. Wainberg
    American Society for Biochemistry {\&} Molecular Biology ({ASBMB}), 2000年11月, Journal of Biological Chemistry, 276(9) (9), 6711 - 6719
    [査読有り]
    研究論文（学術雑誌）

  • Masanori KAMEOKA, Katsuya OTA, Toshifumi TETSUKA, Yasuharu TANAKA, Asako ITAYA, Takashi OKAMOTO, Koichiro YOSHIHARA
    2000年03月, Biochemical Journal, 346(3) (3), 641 - 649, 英語
    [査読有り]
    研究論文（学術雑誌）

  • MK Bahmani, M Kameoka, T Goto, K Sano, RB Luftig, K Ikuta
    2000年02月, VIRUS RESEARCH, 66(2) (2), 131 - 137, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Exposure of normal monocyte-derived dendritic cells to human immunodeficiency virus type-1 particles leads to the induction of apoptosis in co-cultured CD4(+) as well as CD8(+) T cells
    S Suzuki, M Tobiume, M Kameoka, K Sato, TA Takahashi, T Mukai, K Ikuta
    2000年, MICROBIOLOGY AND IMMUNOLOGY, 44(2) (2), 111 - 121, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M Kameoka, Y Tanaka, K Ota, A Itaya, K Yoshihara
    1999年08月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 262(1) (1), 285 - 289, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M Kameoka, Y Tanaka, K Ota, A Itaya, K Yamamoto, K Yoshihara
    1999年07月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 261(1) (1), 90 - 94, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Y Tanaka, M Kameoka, K Ota, A Itaya, K Ikuta, K Yoshihara
    1999年03月, EXPERIMENTAL CELL RESEARCH, 247(2) (2), 514 - 524, 英語
    [査読有り]
    研究論文（学術雑誌）

  • PARPがHIV複製に及ぼす影響
    亀岡 正典, 田中 康春, 太田 克矢, 板谷 安佐子, 吉原 紘一朗
    奈良医学会, 1998年12月, Journal of Nara Medical Association, 49(6) (6), 495 - 495, 日本語

  • M Kameoka, W Auwanit, S Suzuki, H Horikoshi, N Khlai-Khlam, T Meguro, K Yamada, Y Tanaka, K Yoshihara, RB Luftig, K Ikuta
    1998年07月, VIRUS RESEARCH, 56(1) (1), 115 - 122, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Dependence on host cell cycle for activation of human immunodeficiency virus type 1 gene expression from latency
    M Tobiume, K Fujinaga, M Kameoka, T Kimura, T Nakaya, T Yamada, K Ikuta
    1998年06月, JOURNAL OF GENERAL VIROLOGY, 79, 1363 - 1371, 英語
    [査読有り]
    研究論文（学術雑誌）

  • K Ikuta, M Kameoka, RB Luftig
    1997年12月, VIRUS RESEARCH, 52(2) (2), 145 - 156, 英語
    [査読有り]

  • S Suzuki, M Kameoka, T Nakaya, T Kimura, N Nishi, K Hirai, K Ikuta
    1997年10月, IMMUNOPHARMACOLOGY, 37(2-3) (2-3), 185 - 190, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M Kameoka, S Suzuki, T Kimura, K Fujinaga, W Auwanit, RB Luftig, K Ikuta
    1997年10月, INTERNATIONAL IMMUNOLOGY, 9(10) (10), 1453 - 1462, 英語
    [査読有り]
    研究論文（学術雑誌）

  • K Yoshihara, K Ota, T Ide, Y Tanaka, M Kameoka, SS Koide
    1997年07月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 236(2) (2), 423 - 426, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Y Nakamura, M Kameoka, M Tobiume, M Kaya, K Ohki, T Yamada, K Ikuta
    1997年04月, VACCINE, 15(5) (5), 489 - 496, 英語
    [査読有り]
    研究論文（学術雑誌）

  • MK Bahmani, M Kameoka, T Nakaya, K Fujinaga, Q Zhong, H Takahashi, T Nakano, M Nakai, S Ueda, IM Jones, RB Luftig, K Ikuta
    1997年04月, AIDS RESEARCH AND HUMAN RETROVIRUSES, 13(6) (6), 523 - 526, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Insertions, duplications and substitutions in restricted gp90 regions of equine infectious anaemia virus during febrile episodes in an experimentally infected horse
    YH Zheng, T Nakaya, H Sentsui, M Kameoka, M Kishi, K Hagiwara, H Takahashi, Y Kono, K Ikuta
    1997年04月, JOURNAL OF GENERAL VIROLOGY, 78, 807 - 820, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Q Zhong, T Nakaya, Y Tateno, K Fujinaga, M Kameoka, M Tateno, K Ikuta
    1997年04月, VACCINE, 15(5) (5), 497 - 510, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Protease-defective, gp120-containing human immunodeficiency virus type 1 particles induce apoptosis more efficiently than does wild-type virus or recombinant gp120 protein in healthy donor-derived peripheral blood T cells
    M Kameoka, T Kimura, YH Zheng, S Suzuki, K Fujinaga, RB Luftig, K Ikuta
    1997年01月, JOURNAL OF CLINICAL MICROBIOLOGY, 35(1) (1), 41 - 47, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Intracellular glutathione as a possible direct blocker of HIV type 1 reverse transcription
    M Kameoka, Y Okada, M Tobiume, T Kimura, K Ikuta
    1996年11月, AIDS RESEARCH AND HUMAN RETROVIRUSES, 12(17) (17), 1635 - 1638, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M Kameoka, T Kimura, Q Zhong, YH Zheng, RB Luftig, K Ikuta
    1996年11月, INTERNATIONAL IMMUNOLOGY, 8(11) (11), 1687 - 1697, 英語
    [査読有り]
    研究論文（学術雑誌）

  • [Studies on susceptibility of promonocytic cell line U937-derived subclones to HIV-1 infection and apoptosis induction].
    亀岡 正典
    1996年07月, [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 71(4) (4), 489 - 508, 日本語
    [査読有り]

  • N Wada, N Ohara, M Kameoka, Y Nishino, S Matsumoto, T Nishiyama, M Naito, H Yukitake, Y Okada, K Ikuta, T Yamada
    1996年02月, Scandinavian journal of immunology, 43(2) (2), 202 - 209, 英語
    [査読有り]
    研究論文（学術雑誌）

  • High susceptibility of U937-derived subclones to human immunodeficiency virus type 1 infection correlates with accumulation of unintegrated circular viral DNA
    M Kameoka, T Kimura, Y Okada, K Fujinaga, T Nakaya, H Takahashi, M Kishi, K Ikuta
    1996年, VIRUS GENES, 12(2) (2), 117 - 129, 英語
    [査読有り]
    研究論文（学術雑誌）

  • EXTRACELLULAR NEF PROTEIN REGULATES PRODUCTIVE HIV-1 INFECTION FROM LATENCY
    K FUJINAGA, Q ZHONG, T NAKAYA, M KAMEOKA, T MEGURO, K YAMADA, K IKUTA
    1995年12月, JOURNAL OF IMMUNOLOGY, 155(11) (11), 5289 - 5298, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Y OKADA, M KAMEOKA, T KIMURA, AZUMA, I, K IKUTA
    1995年11月, IMMUNOPHARMACOLOGY, 31(1) (1), 73 - 84, 英語
    [査読有り]
    研究論文（学術雑誌）

  • INHIBITION AND DOWN-REGULATION OF POLY(ADP-RIBOSE) POLYMERASE RESULTS IN A MARKED RESISTANCE OF HL-60 CELLS TO VARIOUS APOPTOSIS-INDUCERS
    Y TANAKA, K YOSHIHARA, Y TOHNO, K KOJIMA, M KAMEOKA, T KAMIYA
    1995年09月, CELLULAR AND MOLECULAR BIOLOGY, 41(6) (6), 771 - 781, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Y TANAKA, K YOSHIHARA, K KOJIMA, A ITAYA, M KAMEOKA, K IKUTA, T KAMIYA
    1995年08月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 213(1) (1), 161 - 168, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M KAMEOKA, T KIMURA, Y OKADA, T NAKAYA, M KISHI, K IKUTA
    1995年06月, IMMUNOPHARMACOLOGY, 30(1) (1), 89 - 101, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Y OKADA, T KIMURA, M KAMEOKA, M KISHI, AZUMA, I, K IKUTA
    1995年06月, IMMUNOPHARMACOLOGY, 30(1) (1), 27 - 39, 英語
    [査読有り]
    研究論文（学術雑誌）

  • THE CARBOXYL-TERMINAL REGION OF HIV-1 NEF PROTEIN IS A CELL-SURFACE DOMAIN THAT CAN INTERACT WITH CD4(+) T-CELLS
    K OTAKE, Y FUJII, T NAKAYA, Y NISHINO, Q ZHONG, K FUJINAGA, M KAMEOKA, K OHKI, K IKUTA
    1994年12月, JOURNAL OF IMMUNOLOGY, 153(12) (12), 5826 - 5837, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Y NISHINO, M KAMEOKA, Y OKADA, Q ZHONG, T KIMURA, AZUMA, I, K IKUTA
    1994年05月, VACCINE, 12(6) (6), 485 - 491, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Kameoka M, Nishino Y, Matsuo K, Ohara N, Kimura T, Yamazaki A, Yamada T, Ikuta K
    1994年02月, Vaccine, 12(2) (2), 153 - 158, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M KAMEOKA, T KIMURA, K IKUTA
    1993年09月, FEBS LETTERS, 331(1-2) (1-2), 182 - 186, 英語
    [査読有り]
    研究論文（学術雑誌）

  • T KIMURA, M KAMEOKA, K IKUTA
    1993年07月, FEBS LETTERS, 326(1-3) (1-3), 232 - 236, 英語
    [査読有り]
    研究論文（学術雑誌）

■ MISC
  • アメントフラボンのB型肝炎ウイルス感染阻害活性について
    靱千恵, INDRASETIAWAN Puguh, 深野顕人, 村松正道, 堀田博, 堀田博, 亀岡正典
    2021年, 日本ウイルス学会学術集会プログラム・予稿集(Web), 68th

  • インドネシアの食肉から分離された薬剤耐性Salmonella entericaの遺伝子解析
    高市 果希, 大澤 佳代, 重村 克巳, 北川 孝一, 木下 承晧, 楠木 まり, 宮良 高維, Dadik Raharjo, Kuntaman Kuntaman, 亀岡 正典, 藤澤 正人, 白川 利朗
    (一社)日本臨床微生物学会, 2020年12月, 日本臨床微生物学会雑誌, 31(Suppl.1) (Suppl.1), 201 - 201, 日本語

  • Mitochondrial DNA depletion among HIV-infected patients at Sanjiwani Hospital, Gianyar, Bali
    S. Masyeni, D. G. Budiyasa, S. A. Aryastuti, H. Sukmawati, D. Megawati, T. Kotaki, S. Q. Khairunisa, Arijana, S. Ueda, Nasronudin, M. Kameoka
    2017年09月, INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 50, S82 - S82, 英語
    研究発表ペーパー・要旨（国際会議）

  • 神戸大学インドネシア拠点のあゆみと実績
    内海 孝子, 清水 一史, 小瀧 将裕, 亀岡 正典, 白川 利朗, 堀田 博, 林 祥剛
    2015年04月, 最新医学, 74(4) (4), 745 - 743, 日本語
    [査読有り][招待有り]
    その他

  • Toshiro Shirakawa, Kazufumi Shimizu, Takako Utsumi, Masanori Kameoka, Hak Hotta, Yoshitake Hayashi
    Fuji Technology Press, 2014年10月01日, Journal of Disaster Research, 9(5) (5), 828 - 835, 英語
    書評論文,書評,文献紹介等

  • S. Sapsutthipas, N. Tsuchiya, P. Pathipavanich, K. Ariyoshi, P. Sawanpanyalert, P. Israngkura-na-Ayuthaya, M. Kameoka
    2012年06月, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 16, E191 - E191, 英語
    研究発表ペーパー・要旨（国際会議）

  • P. Utachee, S. Nakamura, P. Isarangkura-na-Ayuthaya, K. Tokunaga, P. Sawanpanyalert, K. Ikuta, W. Auwanit, M. Kameoka
    2012年06月, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 16, E193 - E194, 英語
    研究発表ペーパー・要旨（国際会議）

  • C. Verathamjamras, Y. -S. Tian, T. Yasunaga, T. Takagi, N. Kawashita, M. Kameoka
    2012年06月, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 16, E194 - E194, 英語
    研究発表ペーパー・要旨（国際会議）

  • シクロフィリンAをターゲットとする新たな候補を見つけるための分子ドッキング法の検討(Investigation of molecular docking method in order to find novel candidates targeting cyclophilin A)
    田 雨時, 川下 理日人, 岡本 晃典, Verathamjamras Chris, 安永 照雄, 生田 和良, 亀岡 正典, 高木 達也
    日本エイズ学会, 2011年11月, 日本エイズ学会誌, 13(4) (4), 482 - 482, 日本語

  • Tian Yu-Shi, Kawashita Norihito, Verathamjamras Chris, Okamoto Kousuke, Yasunaga Teruo, Kameoka Masanori, Takagi Tatsuya
    2011年05月, ANTIVIRAL RESEARCH, 90(2) (2), A76 - A77
    [査読有り]

  • CypAをターゲットとする抗HIV-1低分子化合物のin Silico探索
    田 雨時, 川下 理日人, Chris Verathamjamras, 杉本 裕昌, 岡本 晃典, 安永 照雄, 亀岡 正典, 高木 達也
    (公社)日本薬学会, 2011年03月, 日本薬学会年会要旨集, 131年会(4) (4), 126 - 126, 日本語

  • Piyamat Jinnopat, Panasda Isarangkura-Na-Ayuthaya, Piraporn Utachee, Yukiko Kitagawa, U. Chandimal de Silva, Uamporn Siripanyaphinyo, Yoko Kameoka, Kenzo Tokunaga, Pathom Sawanpanyalert, Kazuyoshi Ikuta, Wattana Auwanit, Masanori Kameoka
    2009年11月, JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 52(3) (3), 320 - 328, 英語

  • Masanori Kameoka, Yoko Kameoka, Piraporn Utachee, Takeshi Kurosu, Pathom Sawanpanyalert, Kazuyoshi Ikuta, Wattana Auwanit
    2009年10月, AIDS RESEARCH AND HUMAN RETROVIRUSES, 25(10) (10), 1005 - 1011, 英語

  • Wattana Auwanit, Panasda Isarangkura-Na-Ayuthaya, Dao Kasornpikul, Kazuyoshi Ikuta, Pathom Sawanpanyalert, Masanori Kameoka
    2009年06月, AIDS RESEARCH AND HUMAN RETROVIRUSES, 25(6) (6), 625 - 631, 英語

  • Piraporn Utachee, Piyamat Jinnopat, Panasda Isarangkura-na-ayuthaya, U. Chandimal de Silva, Shota Nakamura, Uamporn Siripanyaphinyo, Nuanjun Wichukchinda, Kenzo Tokunaga, Teruo Yasunaga, Pathom Sawanpanyalert, Kazuyoshi Ikuta, Wattana Auwanit, Masanori Kameoka
    2009年03月, MICROBES AND INFECTION, 11(3) (3), 334 - 343, 英語

  • Piraporn Utachee, Piyamat Jinnopat, Panasda Isarangkura-na-ayuthaya, Udayanga Chandimal de Silva, Shota Nakamura, Uamporn Siripanyaphinyo, Nuanjun Wichukchinda, Kenzo Tokunaga, Teruo Yasunaga, Pathom Sawanpanyalert, Kazuyoshi Ikuta, Wattana Auwanit, Masanori Kameoka
    2009年02月, AIDS RESEARCH AND HUMAN RETROVIRUSES, 25(2) (2), 229 - 236, 英語

  • 新規HIVプロテアーゼ阻害剤を指向した定量的構造活性相関(QSAR)
    杉本裕昌, 川下理日人, 川下理日人, 田雨時, 柏田理恵, 岡本晃典, 亀岡正典, 川瀬雅也, 川瀬雅也, 安永照雄, 高木達也, 高木達也
    2009年, 日本薬学会年会要旨集, 129th(2) (2)

  • Norihito Kawashita, Yu-Shi Tian, Masashi Yasuda, U. Chandimal de Silva, Rie Kashiwada, Shota Nakamura, Naohisa Goto, Rika Nishikiori, Kousuke Okamoto, Masanori Kameoka, Teruo Yasunaga, Masaya Kawase, Kazuyoshi Ikuta, Tatsuya Takagi
    2008年05月, ANTIVIRAL RESEARCH, 78(2) (2), A42 - A42, 英語
    [査読有り]
    研究発表ペーパー・要旨（国際会議）

  • HIV膜融合阻害剤C34に関する構造活性相関研究
    川下 理日人, 田 雨時, 安田 匡志, 岡本 晃典, 錦織 理華, 亀岡 正典, 安永 照雄, 生田 和良, 川瀬 雅也, 高木 達也
    (公社)日本薬学会, 2008年03月, 日本薬学会年会要旨集, 128年会(2) (2), 53 - 53, 日本語

  • Yukiko Kitagawa, Masanor Kameoka, Sanae Shoji Kawata, Yukie Iwabe, Hiroyuki Mizuta, Kenzo Tokunaga, Masato Fujino, Yukikazu Natori, Yoshiaki Yura, Kazuyoshi Ikuta
    2008年03月, VIROLOGY, 373(1) (1), 171 - 180, 英語

  • HIV gp41の蛋白質間相互作用計算によるアミノ酸残基と膜融合阻害活性との相関
    川下 理日人, 田 雨時, 中村 昇太, 岡本 晃典, 後藤 直久, de Silva, U. Chandimal, 亀岡 正典, 川瀬 雅也, 安永 照雄, 生田 和良, 高木 達也
    日本エイズ学会, 2007年11月, 日本エイズ学会誌, 9(4) (4), 405 - 405, 日本語

  • Masanori Kameoka, Yukiko Kitagawa, Piraporn Utachee, Piyamat Jinnopat, Panadda Dhepakson, Panasda Isarangkura-na-ayuthaya, Kenzo Tokunaga, Hironori Sato, Jun Komano, Naoki Yamamoto, Shinobu Oguchi, Yukikazu Natori, Kazuyoshi Ikuta
    2007年08月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 359(3) (3), 729 - 734, 英語

  • HIV-1 gp41 N末端7回反復配列と膜融合阻害剤C34との間の6ヘリックス束モデルの計算アラニン走査
    TIAN Yu-Shi, KAWASHITA Norihito, KAWASHITA Norihito, YASUDA Masashi, KAWAGUCHI Akiko, YAMASHITA Noriyuki, DE SILVA U. Chandimal, NAKAMURA Shota, OKAMOTO Kousuke, GOTO Naohisa, NISHIKIORI Rika, KAMEOKA Masanori, KAMEOKA Masanori, KAWASE Masaya, KAWASE Masaya, YASUNAGA Teruo, YASUNAGA Teruo, IKUTA Kazuyoshi, IKUTA Kazuyoshi, TAKAGI Tatsuya, TAKAGI Tatsuya
    2007年, 情報計算化学生物学会大会予稿集, 2007

  • Computational Studies on Relationship with Protein-Protein Interaction Energy of HIV-1 gp41 and Its Inhibitory Activity of Membrane Fusion
    Kawashita, N, Tian, Y.-s, Nakamura, S, Kawaguchi, A, Yamashita, N, Okamoto, K, de Silva, U. C, Kameoka, M, Yasunaga, T, Ikuta, K, Takagi, T
    2007年01月, 英語

  • 計算化学的手法によるHIV-1 gp41の膜融合阻害活性と蛋白質間相互作用エネルギーとの関連性の考察
    川下理日人, 田雨時, 川口亜希子, 山下典之, 岡本晃典, DE SILVA Udayanga Chandimal, 亀岡正典, 安永照雄, 安永照雄, 生田和良, 生田和良, 高木達也, 高木達也, 高木達也
    2006年, 日本ウイルス学会学術集会プログラム・抄録集, 54th

  • 成熟脳中のApaf-1阻害因子の精製
    太田 克矢, 板谷 安佐子, 亀岡 正典, 田中 康春, 吉原 紘一朗
    (公社)日本生化学会, 2002年08月, 生化学, 74(8) (8), 1088 - 1088, 日本語

  • ヒト免疫不全ウイルス(HIV)やその他のレトロウイルスの増殖機構におけるポリADPリボース合成酵素の役割
    亀岡 正典
    AIDSの原因ウイルスであるヒト免疫不全ウイルス(HIV)やその他のレトロウイルスの生活環の複数の増殖ステップに，ポリADPリボース合成酵素(PARP)が制御因子として関わっている。その制御機構を明らかにすることは，新たなAIDS治療薬を開発する手がかりとなりうるものである。
    奈良医学会, 2002年04月30日, Journal of Nara Medical Association, 53(2) (2), 91 - 99, 日本語

  • PARP欠損細胞における熱ショック誘導アポトーシスの亢進
    田中 康春, 太田 克矢, 亀岡 正典, 板谷 安佐子, 吉原 紘一朗
    (公社)日本生化学会, 2001年08月, 生化学, 73(8) (8), 983 - 983, 日本語

  • Tat依存的なHIV-1転写機構におけるポリADPリボース合成酵素の役割について
    亀岡 正典, 田中 康春, 太田 克矢, 板谷 安佐子, 吉原 紘一朗
    (公社)日本生化学会, 2001年08月, 生化学, 73(8) (8), 1033 - 1033, 日本語

  • Apaf-1依存性のcaspase活性化 胸腺,脳,肝臓組織における比較
    板谷 安佐子, 太田 克矢, 亀岡 正典, 田中 康春, 吉原 紘一朗
    (公社)日本生化学会, 2000年08月, 生化学, 72(8) (8), 935 - 935, 日本語

  • アポトーシスならびにネクローシスにおけるポリADPリボース合成酵素の相反する役割
    田中 康春, 太田 克矢, 板谷 安佐子, 辰巳 晃子, 亀岡 正典, 吉原 紘一朗
    (公社)日本生化学会, 2000年08月, 生化学, 72(8) (8), 935 - 935, 日本語

  • 成熟脳におけるApaf-1経由のアポトーシス経路の停止
    太田 克矢, 板谷 安佐子, 亀岡 正典, 田中 康春, 吉原 紘一朗
    (公社)日本生化学会, 2000年08月, 生化学, 72(8) (8), 935 - 935, 日本語

  • ポリ(ADP-リボース)合成酵素によるNF-κBの調節機構
    亀岡 正典, 太田 克矢, 手塚 俊文, 田中 康春, 板谷 安佐子, 岡本 尚, 吉原 紘一朗
    (公社)日本生化学会, 1999年08月, 生化学, 71(8) (8), 820 - 820, 日本語

  • 牛の脳及び胸腺のcaspaseと活性化因子
    板谷 安佐子, 太田 克矢, 亀岡 正典, 田中 康春, 吉原 紘一朗
    (公社)日本生化学会, 1999年08月, 生化学, 71(8) (8), 822 - 822, 日本語

  • 牛胸腺抽出液におけるcaspaseの活性化機構
    太田 克矢, 板谷 安佐子, 亀岡 正典, 田中 康春, 吉原 紘一朗
    奈良医学会, 1998年12月, Journal of Nara Medical Association, 49(6) (6), 495 - 495, 日本語

  • アポトーシスの分子機構 牛胸腺抽出液中のcaspase-3活性化因子
    吉原 紘一朗, 田中 康春, 板谷 安佐子, 太田 克矢, 亀岡 正典
    (公社)日本生化学会, 1998年08月, 生化学, 70(8) (8), 787 - 787, 日本語

  • U937由来サブクローンのアポトーシス誘導感受性の解析
    田中 康春, 亀岡 正典, 太田 克矢, 板谷 安佐子, 生田 和良, 吉原 紘一朗
    (公社)日本生化学会, 1998年08月, 生化学, 70(8) (8), 1050 - 1050, 日本語

  • Dependence of host cell cycle for activation of human immunodeficiency virus type 1 gene expression from latency
    Tobiume Minoru, Fujinaga Koh, Kameoka Masanori, Kimura Takuro, Nakaya Takaaki, Yamada Takeshi, Ikuta Kazuyoshi
    北海道大学, 1998年, Collected papers from the Institute of Immunological Science Hokkaido University, 21, 80 - 88, 英語

  • A specific T-cell subset with CD4+/CD38- markers derived from HIV-1 cariers induses apoptosis in healthy donor-derived T-lymphocytes.
    Kameoka Masanori, Wattana Auwanit, Suzuki Satoko, Horikoshi Haruko, Natapong Khlai-Khkam, Meguro Takashi, Yamada Kaneo, Tanaka Yasuharu, Yoshihara Koichiro, Luftig Ronald.B, Ikuta Kazuyoshi
    北海道大学, 1998年, Collected papers from the Institute of Immunological Science Hokkaido University, 21, 101 - 108, 英語

  • Persistent infection of U937 cells with HIV-1 blocks CPP32-dependent apoptotic pathway in the cells
    Y Tanaka, M Kameoka, K Ikuta, K Yoshihara
    1997年07月, FASEB JOURNAL, 11(9) (9), A981 - A981, 英語
    研究発表ペーパー・要旨（国際会議）

  • Insertions, duplications and substitutions in restricted gp90 regions of equine infectious anemia virus occurred during febrile episodes in an experimentally infected horse.
    Zheng Yong-Hui, Nakaya Takaaki, Sentsui Hiroshi, Kameoka Masanori, Kishi Masahiko, Hagiwara Katsuro, Takahashi Hirokazu, Kono Yuji, Ikuta Kazuyoshi.
    北海道大学, 1997年, Collected papers from the Institute of Immunological Science Hokkaido University, 20, 46 - 59, 英語

  • Protease-defective, gp120-containing human immunodeficiency virus type 1 particles induce apoptosis more efficiently than does wild-type virus or recombinant gp120 protein in healthy donor-derived peripheral blood T cells.
    Kameoka Masanori, Kimura Takuro, Zheng Yong-Hui, Suzuki Satoko, Fujinaga Koh, Luftig Ronald B., Ikuta Kazuyoshi
    北海道大学, 1997年, Collected papers from the Institute of Immunological Science Hokkaido University, 20, 17 - 23, 英語

  • A chain section containing epitopes for cytotoxic T, B and helper T cells within a highly conserved region found in the human immunodeficiency virus type 1 Gag protein.
    Nakamura Yurie, Kameoka Masanori, Tobiume Minoru, Kaya Masumi, Ohki Kohji, Yamada Takeshi, Ikuta Kazuyoshi.
    北海道大学, 1997年, Collected papers from the Institute of Immunological Science Hokkaido University, 20, 60 - 67, 英語

  • Superoxide generation by monocytes following infection with human cytomegalovirus.
    Suzuki Satoko, Kameoka Masanori, Nakaya Takaaki, Kimura Takuro, Nishi Norio, Hirai Kanji, Ikuta Kazuyoshi
    北海道大学, 1997年, Collected papers from the Institute of Immunological Science Hokkaido University, 20, 125 - 130, 英語

  • E Intracellular glutathione as a possible direct blocker of HIV type 1 reverse transcription.
    Kameoka M., Okada Y., Tobiume M., Kimura T., Ikuta K.
    北海道大学, 1996年, Collected papers from the Institute of Immunological Science Hokkaido University, 19, 74 - 77, 英語

  • Stimulation of human immunodeficiency virus type 1 infected cells with superoxide enhances the chemotactic motile response of CD4+ human cells: implication for virus transmission by cell-to-cell interaction.
    Okada Yohei, Kameoka Masanori, Kimura Takuro, Azuma Ichiro, Ikuta Kazuyoshi
    北海道大学, 1995年, Collected papers from the Institute of Immunological Science Hokkaido University, 18, 31 - 42, 英語

  • High susceptibility of U937-derived subclone to infection with human immunodeficiency virus type 1 is correlated with virus-induced celldifferentiation and superoxide generation.
    Kameoka Masanori, Kimura Takuro, Okada Yohei, Nakaya Takaaki, Kishi Masahiko, Ikuta Kazuyoshi
    北海道大学, 1995年, Collected papers from the Institute of Immunological Science Hokkaido University, 18, 43 - 55, 英語

  • Poly(ADP-ribose) polymerase activity in various U937 cell subclones with different susceptibility to HIV-1 infection : Its dramatic decre ase following persistent virus infection.
    Tanaka Yasuharu, Yoshihara Koichiro, Kojima Kuniyuki, Itaya Asako, Kameoka Masanori, Ikuta Kazuyoshi, Kamiya Tomoya
    北海道大学, 1995年, Collected papers from the Institute of Immunological Science Hokkaido University, 18, 69 - 76, 英語

  • EXTRACELLULAR NEF PROTEIN REGULATES ACTIVATION OF HIV-INFECTION FROM LATENTLY INFECTED-CELLS
    K FUJINAGA, Q ZHONG, T NAKAYA, M KAMEOKA, T MEGURO, K YAMADA, K IKUTA
    1995年, AIDS RESEARCH AND HUMAN RETROVIRUSES, 11, S117 - S117, 英語
    研究発表ペーパー・要旨（国際会議）

  • APOPTOTIC CELL-LYSIS INDUCED BY DEFECTIVE, HIV PROTEASE-DEFICIENT PARTICLES
    M KAMEOKA, T KIMURA, K FUJINAGA, T NAKAYA, M KISHI, K IKUTA, RB LUFTIG
    1995年, AIDS RESEARCH AND HUMAN RETROVIRUSES, 11, S112 - S112, 英語
    研究発表ペーパー・要旨（国際会議）

  • In vivo induction of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes and delayed-type hypersensitivity by a @@S ' 23-amino acid peptide from the highly conserved region in major @@S ' core protein p24
    Nishino Yoshii, Kameoka Masanori, Okada Yohei, Zhong Qiu, Kimura Takuro, Azuma Ichiro, Ikuta Kazuyoshi
    北海道大学, 1994年, Collected papers from the Institute of Immunological Science Hokkaido University, 17, 85 - 94, 英語

  • Cytotoxic T lymphocyte response in mice induced by a recombinant BCG Vaccination which produces an extracellular α antigen that @@S ' fused with the human immunodeficiency virus type 1 envelope immuno @@S dominant domain in the V3 loop.
    Kameoka Masanori, Nishino Yoshii, Matsuo Kazuhiro, Ohara Naoya, Kimura Takuro, Yamazaki Akihiro, Yamada Takeshi, Ikuta Kazuyosh
    北海道大学, 1994年, Collected papers from the Institute of Immunological Science Hokkaido University, 17, 71 - 76, 英語

  • The carboxyl-terminal region of HIV-1 Nef protein is a cell surface domain that can interact with CD4+ T cells
    Otake Kaori, Fujii Yoichi, Nakaya Takaaki, Nishino Yoshii, Zhong Qiu, Fujinaga Koh, Kameoka Masanori, Ohki Kohji, Ikuta Kazuyoshi
    北海道大学, 1994年, Collected papers from the Institute of Immunological Science Hokkaido University, 17, 59 - 70, 英語

  • Superoxide enhances the spread of HIV-1 infection by cell-to-cell
    Kameoka Masanori, Kimura Takuro, Ikuta Kazuyoshi
    北海道大学, 1993年, Collected papers from the Institute of Immunological Science Hokkaido University, 16, 80 - 86, 英語

■ 講演・口頭発表等
  • 次亜塩素酸水溶液および過酸化水素水のドライフォグ噴霧によるSARS-CoV-2不活性化
    亀岡正典, 漆谷雅弘, 川吉 明, 小瀧将裕, 佐伯圭一, 森 康子
    第68回日本ウイルス学会学術集会, 2021年11月

  • 黄熱ウイルスレプリコンを用いた自己複製可能なSARS-CoV-2 RNAワクチンの構築
    中村叡奈, 小瀧将裕, 長井友理恵, 亀岡正典
    第68回日本ウイルス学会学術集会, 2021年11月

  • 抗体依存性感染増強を起こさない抗デング組換え単鎖抗体の作製および評価
    長井友理恵, 小瀧将裕, 中村叡奈, 亀岡正典
    第68回日本ウイルス学会学術集会, 2021年11月

  • アメントフラボンのB型肝炎ウイルス感染阻害活性について
    靱 千恵, Puguh, Indrasetiawan, 深野顕人, 村松正道, 堀田 博, 亀岡正典
    第68回日本ウイルス学会学術集会, 2021年11月

  • MARCH8は様々なウイルスエンベロープ糖蛋白質の細胞質領域リジン残基を標的とする
    Yanzhao Zhang, Seiya Ozono, Takuya Tada, Minoru Tobiume, Masanori Kameoka, Satoshi Kishigami, Hideaki Fujita, Kenzo Tokunaga
    第68回日本ウイルス学会学術集会, 2021年11月

  • アメントフラボンのB型肝炎ウイルス、C型肝炎ウイルス感染阻害活性について
    靱 千恵, 亀岡正典, Jamilah Abbas, Muhammad Hanafi, 堀田 博
    日本薬学会第141年会, 2021年03月

  • PMLタイプJCポリオーマウイルスの培養細胞における増殖
    第67回日本ウイルス学会学術集会, 2019年10月

  • 抗体依存性感染増強活性を示さない組換え型中和抗デングウイルス抗体の解析
    Tomohiro Kotaki, Takeshi Kurosu, Masanori Kameoka
    第67回日本ウイルス学会学術集会, 2019年10月

  • ネパール大地震がHIV感染者の服薬アドヒアランス、メンタルヘルスと薬剤耐性変異の出現におよぼす影響について
    Bharat Singh Negi, 岡 達也, Sunil, Kumar Joshi, 中澤 港, 小瀧将裕, Anup Bastola, 亀岡正典
    第33回近畿エイズ研究会, 2019年, 日本語

  • CRISPR/Cas9 System Targeting Regulatory Genes of HIV-1 Inhibits Viral Replication in Infected T-Cell Cultures
    YOUDIIL OPHINNI, 井上 真里, 小瀧 将裕, 亀岡 正典, 林 祥剛
    第４１回日本分子生物学会年会, 2018年11月, 英語, 日本分子生物学会, 横浜, 国内会議
    ポスター発表

  • デングウイルスの感染増強を起こさない日本脳炎ワクチンの開発
    小瀧将裕, 山中敦史, 小西英二, 亀岡正典
    第22回日本ワクチン学会学術集会, 2018年, 日本語, 国内会議
    口頭発表（一般）

  • デングウイルスに対する感染増強抗体を誘導しない日本脳炎ワクチンの開発
    小瀧将裕, 山中敦史, 小西英二, 亀岡正典
    第53回日本脳炎ウイルス生態学研究会, 2018年, 日本語, 国内会議
    口頭発表（一般）

  • prM領域を改変したデングウイルス2型DNAワクチンの評価
    小瀧将裕, 亀岡正典
    第66回日本ウイルス学会学術集会, 2018年, 日本語, 国内会議
    口頭発表（一般）

  • デングウイルスの増殖に関連する宿主細胞因子の検索
    近澤あずさ, 小瀧将裕, 亀岡正典
    第24回 トガフラビペスチウイルス研究会, 2017年, 日本語, 国内会議
    口頭発表（一般）

  • デングウイルスに対する血清型特異的抗体の樹立
    坂倉裕基, 小瀧将裕, 亀岡正典
    第24回 トガフラビペスチウイルス研究会, 2017年, 日本語, 国内会議
    口頭発表（一般）

  • Nearly full-length sequencing of HIV-1 subtype B in Indonesia
    上田修平, 小瀧将裕, 亀岡正典
    第65回日本ウイルス学会, 2017年, 日本語, 国内会議
    ポスター発表

  • IV-1 CRF01_AE株がgp120 CD4結合部位を認識する単クローン抗体VRC01に対して中和抵抗性を示す分子機構
    亀岡正典, 小瀧将裕
    第31回近畿エイズ研究会学術集会, 2017年, 日本語, 国内会議
    口頭発表（一般）

  • High prevalence of HIV-1 CRF01_AE viruses among female commercial sex workers residing in Surabaya, Indonesia
    Tomohiro Kotaki, Siti Qamariyah Khairunisa, Septhia Dwi Sukartiningrum, M. Vitanata Arfijanto, Takako Utsumi, Irine Normalina, Retno Handajani, Prihartini Widiyanti, Musofa Rusli, Retno Pudji Rahayu, Maria Inge Lusida, Yoshitake Hayashi, Nasronudin, Masanori Kameoka
    Asia-Africa Research Forum on Emerging and Reemerging Infections 2014, 2017年, 英語, 国際会議
    口頭発表（一般）

  • Genotypic characterization of human immunodeficiency virus type 1 derived from infected individuals residing in Bali, Indonesia
    Siti Qamariyah Khairunisa, Tomohiro Kotaki, Masanori Kameoka
    第65回日本ウイルス学会, 2017年, 英語, 国内会議
    ポスター発表

  • Characterization of HIV-1 env genes derived from recently infected Indonesian individuals
    佐々木麻帆, 小瀧将裕, 亀岡正典
    第65回日本ウイルス学会, 2017年, 日本語, 国内会議
    ポスター発表

  • Appearance of drug resistance-associated mutations in human immunodeficiency virus type 1 protease and reverse transcriptase derived from infected individuals in Papua, Indonesia
    Adiana Mutamsari Witaningrum, Tomohiro Kotaki, Masanori Kameoka
    第65回日本ウイルス学会, 2017年, 英語, 国内会議
    ポスター発表

  • Analysis of an epitope located near the glycosylation site on the domain II of dengue virus type 1 E protein
    小瀧将裕, 亀岡正典
    第65回日本ウイルス学会, 2017年, 日本語, 国内会議
    ポスター発表

  • デングウイルス1型望月株に対して強力な中和活性を示すマウスモノクローナル抗体のエピトープ解析
    小瀧将裕, 亀岡正典
    第51回 日本脳炎ウイルス生態学研究会, 2016年, 日本語, 国内会議
    口頭発表（一般）

  • インドネシアのデング患者血より作製された 抗デングウイルスヒト型モノクローナル抗体の性状解析
    小瀧将裕, 亀岡正典
    第23回 トガフラビペスチウイルス研究会, 2016年, 日本語, 国内会議
    口頭発表（一般）

  • Molecular epidemiology of Dengue Virus in 4 cities of East Java, Indonesia
    Soegeng Soegijanto, Kris Cahyo Mulyatno, Siti Churotin, Amaliah Labiqah, Teguh Hari Sucipto, Tomohiro Kotaki, Masanori Kameoka, Eiji Konishi, Atsushi Yamanaka
    Asia-Africa Research Forum on Emerging and Reemerging Infections 2014, 2016年, 英語, 国際会議
    口頭発表（一般）

  • Characterization of human monoclonal antibodies against dengue virus generated from Indonesian dengue patients
    小瀧将裕, 亀岡正典
    第64回 日本ウイルス学会, 2016年, 英語, 国内会議
    口頭発表（一般）

  • Generation of human monoclonal antibody using peripheral blood lymphocytes from dengue patient in Indonesia
    Siti Churrrotin, Amaliah Labiqah, Teguh Hari Sucipto, Kris Cahyo Mulyatno, Orapim Puiprom, Tomohiro Kotaki, Tamaki Okabayashi, Kazuyoshi Ikuta, Masanori Kameoka, Soegeng Soegijanto
    Asia-Africa Research Forum on Emerging and Reemerging Infections 2014, 2015年, 英語, 国際会議
    ポスター発表

  • Divergence of dengue virus 2 Cosmopolitan genotype associated with two predominant serotype shifts between 1 and 2 in Surabaya, Indonesia
    小瀧将裕, 亀岡正典
    第63回 日本ウイルス学会学術集会, 2015年, 日本語, 国内会議
    ポスター発表

  • 東南アジアで流行するHIVの特徴
    亀岡正典
    第28回日本エイズ学会学術集会・総会, 2014年12月, 日本語, 日本エイズ学会, 大阪, 国内会議
    [招待有り]
    シンポジウム・ワークショップパネル（指名）

  • ビオチン化PIの分子設計と活性プロテアーゼの同定
    日高興士, 亀岡正典, 木曽良明, 津田裕子
    第28回日本エイズ学会学術集会・総会, 2014年12月, 日本語, 日本エイズ学会, 大阪, 国内会議
    口頭発表（一般）

  • インドネシア・スラバヤ市の性産業従事者におけるHIV流行
    亀岡正典, 小瀧将裕, Siti Qamariyah Khairunisa, Septhia Dwi Sukartiningrum, M. Vitanata Arfijanto, 内海孝子, Irine Normalina, Retno Handajani, Prihartini Widiyanti, Musofa Rusli, Retno Pudji Rahayu, Maria Inge Lusida, 林 祥剛, Nasronudin
    第28回日本エイズ学会学術集会・総会, 2014年12月, 日本語, 日本エイズ学会, 大阪, 国内会議
    口頭発表（一般）

  • Dengue virus infection-neutralizing and enhancing antibody responses in central Thai populations against Indonesian and Thai strains.
    山中敦史, Oddgun D, Chantawat N, Okabayashi T, Ramasoota P, Churrotin S, 小瀧将裕, 亀岡正典, Soegijanto S, 小西英二
    Joint International Tropical Medicine Meeting (JITMM 2014) and Food borne Parasites and Zoonoses 8 (FBPZ8), 2014年12月, 英語, Mahidol University, バンコク, タイ, 国際会議
    口頭発表（一般）

  • ヒト神経芽細胞腫でのTNF-αによるJCウイルスDNA複製の促進
    奴久妻総一, 亀岡正典, 中道一生, 杉浦重樹, 奴久妻智代子, 田崎隆史, 竹上勉
    第62回日本ウイルス学会学術集会, 2014年11月, 日本語, 日本ウイルス学会, 横浜, 国内会議
    口頭発表（一般）

  • インドネシアの薬剤未治療HIV-1患者における薬剤耐性変異の解析
    小瀧将裕, Siti Qamariyah Khairunisa, Adiana Mutamsari Witaningrum, Muhammad, Qushai Yunifiar M, Septhia Dwi Sukartiningrum, M. Noor Diansyah, Retno Pudji Rahayu, Nasronudin, 亀岡正典
    第62回日本ウイルス学会学術集会, 2014年11月, 日本語, 日本ウイルス学会, 横浜, 国内会議
    ポスター発表

  • インドネシアのデング患者血を用いた抗デングウイルスヒト型モノクローナル抗体の樹立
    小瀧将裕, Siti Churrotin, Nur Laila Fitriati Ahwanah, Soegeng Soegijanto, 小西英二, Orapim Puiprom, 岡林環樹, 生田和良, 亀岡正典
    第21回トガ・フラビ・ペスチウイルス研究会, 2014年11月, 日本語, 国立感染症研究所, 横浜, 国内会議
    口頭発表（一般）

  • インドネシア・スラバヤ市に流行するHIV-1の遺伝子解析
    小瀧将裕, Siti Qamariyah Khairunisa, Septhia Dwi Sukartiningrum, Adiana Mutamsari Witaningrum, Musofa Rusli, M. Noor Diansyah, Nasronudin, 亀岡正典
    第28回近畿エイズ研究会学術集会, 2014年06月, 日本語, 近畿エイズ研究会, 大阪, 国際会議
    口頭発表（一般）

  • ビオチン化アスパラギン酸プロテアーゼ阻害剤を用いたHIVプロテアーゼ研究
    日高興士, 木曽良明, 亀岡 正典, 津田裕子
    日本薬学会年会, 2014年03月, 日本語, 国内会議
    口頭発表（一般）

  • Appearance of drug resistance-associated mutations in human immunodeficiency virus type 1 protease, reverse transcriptase and integrase derived from drug-naïve Indonesian patients
    Siti Qamariyah Khairunisa, Tomohiro Kotaki, Septhia Dwi Sukartiningrum, Nasronudin, Masanori Kameoka
    Asia-Africa Research Forum on Emerging and Reemerging Infections 2014, 2014年, 英語, 国際会議
    ポスター発表

  • Molecular epidemiology of dengue virus in 4 cities of east Java, Indonesia.
    Soegijanto, S, Mulyatno, K. C, Churotin, S, Labiqah, A, Sucipto, T. H, Kotaki, T, Kameoka, M, Konishi, E, Yamanaka, A
    Asian-African Research Forum on Emerging and Reemerging infections 2014, 2014年01月, 英語, 国際会議
    口頭発表（一般）

  • Molecular epidemiology of Dengue Virus in 4 cities of East Java, Indonesia
    Soegeng Soegijanto, Kris Cahyo Mulyatno, Siti Churotin, Amaliah Labiqah, Teguh Hari Sucipto, Tomohiro Kotaki, Masanori Kameoka, Eiji Konishi, Atsushi Yamanaka
    Asian-african research forum on emerging and reemerging infections 2014, 2014年01月, 英語, MEXT, J-GRID, 仙台, 国際会議
    口頭発表（一般）

  • High prevalence of HIV-1 CRF01_AE viruses among female commercial sex workers residing in Surabaya, Indonesia.
    Kotaki, T, Khairunisa, S. Q, Sukartiningrum, S. D, Arfijanto, M. V, Utsumi, T, Normalina, I, Handajani, R, Widiyanti, P, Rusli, M, Rahayu, R. P, Lusida, M. I, Hayashi, Y, Nasronudin, Kameoka, M
    Asian-African Research Forum on Emerging and Reemerging infections 2014, 2014年01月, 英語, 国際会議
    口頭発表（一般）

  • High prevalence of HIV-1 CRF01_AE viruses among female commercial sex workers residing in Surabaya, Indonesia.
    Tomohiro Kotaki, Siti Qamariyah Khairunisa, Septhia Dwi Sukartiningrum, M. Vitanata Arfijanto, Takako Utsumi, Irine Normalina, Retno Handajani, Prihartini Widiyanti, Musofa Rusli, Retno Pudji Rahayu, Maria Inge Lusida, Yoshitake Hayashi, Nasronudin, Masanori Kameoka
    Asian-african research forum on emerging and reemerging infections 2014, 2014年01月, 英語, MEXT, J-GRID, 仙台, 国際会議
    口頭発表（一般）

  • Generation of human monoclonal antibody using peripheral blood lymphocytes from dengue patient in Indonesia
    Siti Churrrotin, Amaliah L, Teguh H.S, Kris C.Mulyatno, Orapim Puiprom, Tomohiro Kotaki, Tamaki Okabayashi, Kazuyoshi Ikuta, Soegeng Soegijanto, Masanori Kameoka
    Asian-african research forum on emerging and reemerging infections 2014, 2014年01月, 英語, MEXT, J-GRID, 仙台, 国際会議
    ポスター発表

  • Generation of human monoclonal antibody using peripheral blood lymphocites from dengue patient in Indonesia.
    Churrotin, S, Labiqah, A, Sucipto T. H, Mulyatno, K. C, Puiprom, O, Kotaki, T, Okabayashi, T, Ikuta, K, Kameoka, M, Soegianto, S
    Asian-African Research Forum on Emerging and Reemerging infections 2014, 2014年01月, 英語, 国際会議
    ポスター発表

  • Appearance of drug resistance-associated mutations in human immunodeficiency virus type 1 protease, reverse transcriptase and integrase derived from drug-naïve Indonesian patients.
    Khairunisa, S. Q, Kotaki, T, Sukartiningrum, S. D, Witaningrum, A. M, Rusli, M, Diansyah, M. N, Rahayu. R. P, Nasronudin, Kameoka, M
    Asian-African Research Forum on Emerging and Reemerging infections 2014, 2014年01月, 英語, 国際会議
    ポスター発表

  • Appearance of drug resistance-associated mutations in human immunodeficiency virus type 1 protease, reverse transcriptase and integrase derived from drug-naïve Indonesian patients
    Siti Qamariyah Khairunisa, Tomohiro Kotaki, Septhia Dwi Sukartiningrum, Adiana Mutamsari Witaningrum, Musofa Rusli, M. Noor Diansyah, Retno Pudji Rahayu, Nasronudin, Masanori Kameoka
    Asian-african research forum on emerging and reemerging infections 2014, 2014年01月, 英語, MEXT, J-GRID, 仙台, 国際会議
    ポスター発表

  • 蚊が関係する疾病
    亀岡 正典
    日本環境動物昆虫学会年次大会, 2013年11月, 日本語, 国内会議
    [招待有り]
    シンポジウム・ワークショップパネル（指名）

  • スラバヤ市における2008年から2013年までのデングウイルス分子疫学
    小瀧将裕, 山中敦史, 小西英二, 亀岡 正典
    トガ・フラビ・ペスチウイルス研究会, 2013年11月, 日本語, 国内会議
    口頭発表（一般）

  • インドネシア国スラバヤ市における2008年から2013年までのデングウイルス分子疫学
    小瀧将裕, 山中敦史, 小西英二, 亀岡正典
    第20回 トガ・フラビ・ペスチウイルス研究会, 2013年11月, 日本語, 国立感染症研究所, 神戸, 国内会議
    口頭発表（一般）

  • インドネシア・スラバヤの性産業従事者を対象としたHIV及び肝炎ウイルスの疫学調査
    小瀧将裕, Siti Qamariyah Khairunisa, Septhia Dwi Sukartiningrum, 内海孝子, M. Vitanata Arfijanto, Irine Normalina, Musofa Rusli, Retno Pudji Rahayu, Retno Handajani, Prihartini Widiyanti, Maria Inge Lusida, 林祥剛, Nasronudin, 亀岡正典
    第61回日本ウイルス学会学術集会, 2013年11月, 日本語, 日本ウイルス学会, 神戸, 国内会議
    ポスター発表

  • インドネシア・スラバヤの性産業従事者を対象としたHIVおよび肝炎ウイルスの疫学調査
    小瀧将裕, Siti Qamariyah Khairunisa, Septhia Dwi Sukartiningrum, 内海孝子, M. Vitanata Arfijanto, Irine Normalina, Musofa Rusli, Retno Pudji Rahayu, Retno Handajani, Prihartini Widiyanti, Maria Inge Lusida, 林 祥剛, Nasronudin, 亀岡 正典
    日本ウイルス学会学術集会, 2013年11月, 日本語, 国内会議
    ポスター発表

  • Tetravalent dengue DNA vaccine containing premembrane and envelope genes of dengue virus isolates in Indonesia.
    Dwi Hilda Putri, Novia Rachmayanti, Eni Nuraeni, Angky Budianti, Rina Yunita, Prasetyo Dimas S, Sjatha Fithriyah, Beti E. Dewi, Andriansjah Rukmana, Sudarmono Pratiwi, 亀岡正典, 小西英二, Sudiro T. Mirawati
    第61回日本ウイルス学会学術集会, 2013年11月, 英語, 日本ウイルス学会, 神戸, 国内会議
    口頭発表（一般）

  • Tetravalent dengue DNA vaccine containing premembrane and envelope genes of dengue virus isolates in Indonesia
    Dwi Hilda Putri, Novia Rachmayanti, Eni Nuraeni, Angky Budianti, Rina Yunita, Prasetyo Dimas S, Sjatha Fithriyah, Beti E. Dewi, Andriansjah Rukmana, Sudarmono Pratiwi, 亀岡 正典, 小西英二, Sudiro T. Mirawati
    日本ウイルス学会学術集会, 2013年11月, 英語, 国内会議
    口頭発表（一般）

  • PARP-1阻害剤のin vitroにおけるJCウイルス増殖抑制効果について
    奴久妻聡一, 亀岡 正典, 杉浦重樹, 中道一生, 奴久妻智代子, 田崎隆史, 竹田勉
    日本ウイルス学会学術集会, 2013年11月, 日本語, 国内会議
    口頭発表（一般）

  • HIV-1 CRF01_AE株がgp120 CD4結合部位を認識する単クローン抗体に対して中和抵抗性を示す分子機構
    亀岡 正典, Piraporn Utachee, Panasda Isarangkura-na-ayuthaya, 徳永研三, 生田和良, 武田直和
    日本ウイルス学会学術集会, 2013年11月, 日本語, 国内会議
    口頭発表（一般）

  • Antiviral activity of crude extracts from Japanese medical plants against dengue virus type-2.
    Fithriyah Sjatha, 眞武 紀史, 渕野 裕之, 川原 信夫, 堀田 博, 亀岡 正典
    第61回日本ウイルス学会学術集会, 2013年11月, 日本語, 日本ウイルス学会, 神戸, 国内会議
    ポスター発表

  • Antiviral activity of crude extracts from Japanese medical plants against dengue virus type-2
    Fithriyah Sjatha, 眞武紀史, 渕野裕之, 川原信夫, 堀田 博, 亀岡 正典
    日本ウイルス学会学術集会, 2013年11月, 英語, 国内会議
    ポスター発表

  • インドネシア・スラバヤ市の性産業従事者を対象としたHIVと肝炎ウイルスの疫学調査
    小瀧将裕, Siti Qamariyah Khairunisa, Septhia Dwi Sukartiningrum, Irine Normalina, Musofa Rusli, M. Vitanata Arfijanto, Retno Pudji Rahayu, Maria Inge Lusida, 内海孝子, Nasronudin, 亀岡 正典
    近畿エイズ研究会学術集会, 2013年06月, 日本語, 国内会議
    口頭発表（一般）

  • インドネシア・スラバヤ市の性産業従事者を対象としたHIVと肝炎ウイルスの疫学調査
    小瀧将裕, Siti Qamariyah Khairunisa, Septhia Dwi Sukartiningrum, Irine Normalina, Musofa Rusli, M. Vitanata Arfijanto, Retno Pudji Rahayu, Maria Inge Lusida, 内海孝子, Nasronudin, 亀岡正典
    第27回近畿エイズ研究会学術集会, 2013年06月, 日本語, 近畿エイズ研究会, 大阪, 国内会議
    口頭発表（一般）

  • TNF-αによるJCウイルスのLarge T抗原の発現促進
    奴久妻聡一, 中道一生, 亀岡 正典, 杉浦重樹, 奴久妻智代子, 田崎隆史, 竹上勉
    近畿エイズ研究会学術集会, 2013年06月, 日本語, 国内会議
    口頭発表（一般）

  • Phylogenetic and Molecular Clock Analysis of Dengue Virus Strains Isolated in Surabaya and Sidoarjo, Indonesia, during 2011-2012
    Kris Cahyo Mulyatno, Siti Churrotin, Ika Nindya, Atsushi Yamanaka, Tomohiro Kotaki, Masanori Kameoka, Soegeng Soegijanto, Eiji Konishi
    Asia-Africa Research Forum on Emerging and Reemerging Infections 2013, 2013年, 英語, 国際会議
    ポスター発表

  • Awareness of using Ringer’s Lactate Solution in Dengue Virus Infection can Induce Severity
    Soegeng Soegijanto, Desiana W Sari, Atsushi Yamanaka, Tomohiro Kotaki, Masanori Kameoka, Eiji Konishi
    Asia-Africa Research Forum on Emerging and Reemerging Infections 2013, 2013年, 英語, 国際会議
    ポスター発表

  • Phylogenetic and Molecular Clock Analysis of Dengue Virus Strains Isolated in Surabaya and Sidoarjo, Indonesia, during 2011-2012.
    Mulyatno, K. C, Churrotin, S, Nindya, I, Yamanaka, A, Kotaki, T, Kameoka, M, Soegijanto, S, Konishi, E
    Asian-African Research Forum on Emerging and Reemerging infections 2013, 2013年01月, 英語, 国際会議
    ポスター発表

  • Phylogenetic and Molecular Clock Analysis of Dengue Virus Strains Isolated in Surabaya and Sidoarjo, Indonesia, during 2011-2012
    Mulyatno KC, Churrotin S, Nindya I, Yamanaka A, Kotaki T, Kameoka M, Soegijanto S, Konishi E
    Asian-African Research Forum on Emerging and Reemerging Infections (AARF) 2013, 2013年01月, 英語, Ministry of Education, Culture, Sports, Science and Technology. Japan Initiative for Global Research Network on Infectious Diseases., 東京, Dengue virus (DENV) is transmitted to humans by the bite of an infected Aedes mosquito. Once infected, the mosquito remains infected for life, transmitting the virus to susceptible individuals while probing and feeding. The transmission cycle between humans and mosquitoes is a main mechanism for the maintenance of DENV in a large human populations and abundant Aedes mosquito po, 国際会議
    ポスター発表

  • Awareness of using Ringer’s lactate solution in dengue virus infection can induce severity.
    Soegijanto, S, Sari, D. W, Yamanaka, A, Kotaki, T, Kameoka, M, Konishi, E
    Asian-African Research Forum on Emerging and Reemerging infections 2013, 2013年01月, 英語, 国際会議
    口頭発表（一般）

  • Awareness of using Ringer's lactate solution in dengue virus infection can induce severity
    Soegijanto S, Sari DW, Yamanaka A, Kotaki T, Kameoka M, Konishi E
    Asian-African Research Forum on Emerging and Reemerging Infections (AARF) 2013, 2013年01月, 英語, Ministry of Education, Culture, Sports, Science and Technology. Japan Initiative for Global Research Network on Infectious Diseases., 東京, Dengue virus (DENV) infection is one of the important health problems in Indonesia, although the mortality rate has been decreased. Many cases with dengue shock syndrome and unusual manifestation of dengue infection are difficult to predict the earlier time for getting a good management. We made updated management of unusual manifestation in dengue infection for getting a bette, 国際会議
    口頭発表（一般）

  • タイにおけるJ-GRIDおよびSATREPS研究活動について
    亀岡 正典, 佐々木正大
    日本ウイルス学会学術集会, 2012年11月, 日本語, 国内会議
    [招待有り]
    シンポジウム・ワークショップパネル（指名）

  • タイにおけるJ-GRIDおよびSATREPS研究活動について
    亀岡正典, 佐々木正大
    第60回日本ウイルス学会学術集会, 2012年11月, 日本語, 日本ウイルス学会, 大阪, タイでおこなわれたJ-GRIDおよびSATREPS研究課題の概略を報告した, 国内会議
    シンポジウム・ワークショップパネル（指名）

  • シクロフィリンAとHIV-1 Gagの結合を阻害する新規低分子化合物の検索
    亀岡 正典, Chris Verathamjamras, 田 雨時, 安永照雄, 高木達也, 川下理日人
    日本ウイルス学会学術集会, 2012年11月, 日本語, 国内会議
    ポスター発表

  • シクロフィリンAとHIV-1 Gagの結合を阻害する新規低分子化合物の検索
    亀岡正典, Chris Verathamjamras, 田 雨時, 安永照雄, 高木達也, 川下理日人
    第60回日本ウイルス学会学術集会, 2012年11月, 日本語, 日本ウイルス学会, 大阪, シクロフィリンAとHIV-1 Gagの結合を阻害する低分子化合物を解析して、有効な化合物を見いだした, 国内会議
    ポスター発表

  • HIV-1 Tatによる神経芽細胞腫でのJCウイルス増殖促進
    奴久妻聡一, 亀岡 正典, 杉浦重樹, 中道一生, 奴久妻智代子, 竹上勉
    日本ウイルス学会学術集会, 2012年11月, 日本語, 国内会議
    口頭発表（一般）

  • HIV-1 Tatによる神経芽細胞腫でのJCウイルス増殖促進
    奴久妻聡一, 亀岡正典, 杉浦重樹, 中道一生, 奴久妻智代子, 竹上勉
    第60回日本ウイルス学会学術集会, 2012年11月, 日本語, 日本ウイルス学会, 大阪, HIV-1 Tatにより神経芽細胞腫におけるJCウイルス増殖促進機構を解析した, 国内会議
    口頭発表（一般）

  • HIV-1 TatのPML型JCウイルス増殖促進
    奴久妻聡一, 亀岡正典, 杉浦重樹, 奴久妻智代子, 三好勇夫, 竹上勉
    第26回近畿エイズ研究会学術集会, 2012年07月, 日本語, 近畿エイズ研究会, 神戸, HIV-1 TatによりJCウイルスの増殖が更新する分子機構を解析した, 国内会議
    口頭発表（一般）

  • HIV-1 TatによるJCウイルス増殖促進機構の解明
    奴久妻聡一, 亀岡 正典, 杉浦重樹, 奴久妻智代子, 三好勇夫, 竹上勉
    近畿エイズ研究会学術集会, 2012年07月, 日本語, 国内会議
    口頭発表（一般）

  • HIV-1 CRF01_AE株がCD4結合部位を認識する単クローン抗体に対して中和抵抗性を示す分子機構
    Piraporn Utachee, Panasda Isarangkura-na-ayuthaya, 徳永研三, Pathom Sawanpanyalert, 生田和良, Wattana Auwanit, 亀岡 正典
    近畿エイズ研究会学術集会, 2012年07月, 日本語, 国内会議
    口頭発表（一般）

  • HIV-1 CRF01_AE株がCD4結合部位を認識する単クローン抗体に対して中和抵抗性を示す分子機構
    Piraporn Utachee, Panasda Isarangkura-na-ayuthaya, 徳永研三, Pathom Sawanpanyalert, 生田和良, Wattana Auwanit, 亀岡正典
    第26回近畿エイズ研究会学術集会, 2012年07月, 日本語, 近畿エイズ研究会, 神戸, HIV-1 CRF01_AE株がCD4結合部位を認識する単クローン抗体に対して中和抵抗性を示す分子機構として、外被タンパク質gp120のV2領域の1アミノ酸の役割を明らかにした, 国内会議
    口頭発表（一般）

  • Susceptibility of HIV-1 CRF01_AE viruses to a CD4-binding site monoclonal antibody, IgG1 b12.
    Utachee, P, Nakamura, S, Isarangkura-na-ayuthaya, P, Tokunaga, K, Sawanpanyalert, P, Ikuta, K, Auwanit, W, Kameoka, M
    15th International Congress on Infectious Diseases, 2012年06月, 英語, 国際会議
    ポスター発表

  • In search for a new anti-HIV-1 drug through inhibition of CA-CypA interaction.
    Verathamjamras, C, Tian, Y.-S, Yasunaga, T, Takagi, T, Kawashita, N, Kameoka, M
    15th International Congress on Infectious Diseases, 2012年06月, 英語, 国際会議
    ポスター発表

  • Comparison of anti-HIV-1 neutralizing activity between the plasma derived from HIV-1 infected, slow and rapid progressors.
    Sapsutthipas, S, Tsuchiya, N, Pathipavanich, P, Ariyoshi, K, Sawanpanyalert, P, sarangkura-na-ayuthaya, P, Kameoka, M
    15th International Congress on Infectious Diseases, 2012年06月, 英語, 国際会議
    ポスター発表

  • Some dengue patient sera or monoclonal antibodies exhibit varying focus sizes in a dengue virus infection-enhancing antibody assay system
    Tomohiro Kotaki, Kris Cahyo Mulyatno, Siti Churrotin, Soegeng Soegijanto, Atsushi Yamanaka, Masanori Kameoka, Eiji Konishi
    Indonesia-Japan-Thailand Joint Forum on infectious Diseases 2012, 2012年, 英語, 国際会議
    口頭発表（一般）

  • Sero-epidemiology of HIV-1infection and HBV, HCV co-infection among commercial sex worker in Surabaya, Indonesia
    Siti Qamariyah Khairunisa, Tomohiro Kotaki, Irine Normalina, M. Vitanata Arfijanto, Retno Handayani, Retno Pudji Rahayu, Nasronudin, Masanori Kameoka
    Indonesia-Japan-Thailand Joint Forum on infectious Diseases 2012, 2012年, 英語, 国際会議
    口頭発表（一般）

  • Genotypic study of HIV-1 derived from infected patients and commercial sex workers residing in Surabaya, Indonesia
    Tomohiro Kotaki, Siti Qamariyah Khairunisa, Irine Normalina, M. Vitanata Arfijanto, Retno Handayani, Retno Pudji Rahayu, Nasronudin, Masanori Kameoka
    Indonesia-Japan-Thailand Joint Forum on infectious Diseases 2012, 2012年, 英語, 国際会議
    口頭発表（一般）

  • Evolution of HIV-1 CRF01_AE env gene in Thai patients.
    Kameoka, M, Boonchawalit, S, Jullaksorn, D, Uttiyoung, J, Yowang, A, Krathong, N, Chautrakul, S, Ikuta, K, Roobsoong, A, Kanitvittaya, S, Sawanpanyalert, P
    Asian-African Research Forum on Emerging and Reemerging infections 2012, 2012年01月, 英語, 国際会議
    ポスター発表

  • Anti-HIV-1 humoral immune responses in HIV-1-infected Thai patients.
    Kameoka, M, Sapsutthipas, S, Akapirat, S, Tsuchiya, N, Pathipavanich, P, Ariyoshi, K, Sawanpanyalert, P, Ikuta, K, Leaungwutiwong, P, Ramasoota, P, Isarangkura-na-ayuthaya, P
    Asian-African Research Forum on Emerging and Reemerging infections 2012, 2012年01月, 英語, 国際会議
    口頭発表（一般）

  • CypAをターゲットとする抗HIV-1低分子化合物のin Silico探索
    田 雨時, 川下理日人, Chris Verathamjamras, 杉本裕昌, 岡本晃典, 安永照雄, 亀岡 正典, 高木達也
    日本薬学会年会, 2011年03月, 日本語, 国内会議
    口頭発表（一般）

■ 所属学協会
  • 日本ウイルス学会

■ 共同研究・競争的資金等の研究課題

研究シーズ

■ 研究シーズ
  • ヒト病原性ウイルスの研究
    シーズカテゴリ：ライフサイエンス, 自然科学一般
    研究キーワード：デング, エイズウイルス, SARS-CoV-2, COVID-19
    研究の背景と目的：新興感染症が次々と出現しています。特にヒト病原性ウイルスによる新たな感染症が数年おきに出現して公衆衛生上の問題となっています。ウイルス複製機構の詳細な解析やウイルス感染に対する宿主の免疫応答の解析は、新規の抗ウイルス薬やワクチン開発に欠かせない基礎研究と考えます。
    研究内容：これまで、エイズウイルス(HIV)、デングウイルスを含む蚊媒介感染症の原因となるフラビウイルス、最近ではCOVID-19の原因となるSARS-CoV-2などのヒト病原性ウイルスを対象として、ウイルス複製機構の解析、ウイルス複製に影響を及ぼす宿主細胞タンパク質の探索研究や、ウイルスタンパク質が感染細胞の性状に及ぼす影響などに関する基礎研究を行っています。また、抗ウイルス活性物質を探索するためのスクリーニング系の開発研究、ウイルスに対する中和抗体の活性測定系の開発研究、新規診断法の開発研究なども行っています。
    期待される効果や応用分野：ウイルス感染症の予防、診断、治療に役立つ情報の蓄積を目指しています。
    関係する業績：Kotaki T, Xie X, Shi P-Y, Kameoka M. A PCR amplicon–based SARS-CoV-2 replicon for antiviral evaluation. Scientific Reports 11(1):2229, 2021. 最近、SARS-CoV-2に対する抗ウイルス活性物質のスクリーニング系に応用可能なRNAレプリコンを開発しました。
研究者連絡先、関連サイト
　　　　　
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