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祖父江 慶太郎医学部附属病院 放射線診断・IVR科准教授
研究活動情報
■ 受賞- 2024年03月 Society of Interventional Radiology, JVIR Editor’s Award for Distinguished Laboratory Investigation
- 2024年03月 一般財団法人 村尾育英会, 第41回学術奨励賞
- 2020年01月 神戸大学, 令和元年度神戸大学優秀若手研究者賞
- 2019年12月 日本肝臓学会, 第43回日本肝臓学会西部会 男女共同参画委員会関連企画 優秀賞日本国国内学会・会議・シンポジウム等の賞
- 2018年12月 Radiological Society of North America, Certificate of Merit
- 2017年07月 Society of Advanced Medical Imaging, 第2回Advanced Medical Imaging研究会 大会長賞 最優秀賞, 学会発表国内学会・会議・シンポジウム等の賞
- 2016年09月 日本腹部放射線学会, 日本腹部放射線学会バイエル奨励賞, 個人国内学会・会議・シンポジウム等の賞
- 2015年04月 日本医学放射線学会, 板井研究奨励賞, 個人国内学会・会議・シンポジウム等の賞
- 2014年04月 日本放射線医会, 第26回コニカミノルタ日米放射線医留学生助成
- 2013年12月 Radiological Society of North America, Certificate of Merit
- 2013年09月 Bayer国際交流促進制度 IVR関連国際学会フェローシップ
- Abstract Advancements in computed tomography (CT) technology, particularly the emergence of dual-energy CT (DE-CT) and photon-counting detector CT (PCD-CT), can improve detection, characterization, and treatment monitoring of focal liver lesions. DE-CT, through its ability to differentiate tissues with similar densities and produce diverse datasets, has enhanced lesion visibility and diagnostic precision. PCD-CT further advances imaging with superior spatial resolution and material decomposition capabilities, offering potential for complex diagnostic scenarios. This review aimed to highlight the role of CT in hepatic imaging and its application to focal liver lesions. DE-CT improves lesion detectability using low-energy virtual monochromatic images, which enhance iodine contrast and reduce radiation and contrast agent doses. It also facilitates treatment response evaluation after locoregional therapies for hepatocellular carcinoma by quantifying biomarkers, such as the extracellular volume fraction. This review underscores the transformative impact of DE-CT and PCD-CT on liver imaging, emphasizing their complementary roles alongside magnetic resonance imaging. These innovations have paved the way for more precise diagnostics, improved treatment planning, and enhanced patient outcomes in the management of liver diseases.Ovid Technologies (Wolters Kluwer Health), 2025年04月, Investigative Radiology研究論文（学術雑誌）
- The Japanese Society of Interventional Radiology, 2025年03月, Interventional Radiology, 10, e2024 - 0018研究論文（学術雑誌）
- Background/Objectives: Although immunotherapy is the primary treatment option for intermediate-stage hepatocellular carcinoma (HCC), its efficacy varies. This study aimed to identify non-invasive imaging biomarkers predictive of the immunoscore linked to dynamic contrast-enhanced computed tomography (CECT). Methods: We performed immunohistochemical staining with CD3+ and CD8+ antibodies and counted the positive cells in the invasive margin (IM) and central tumor (CT), converting them to an immunoscore of 0 to 4 points. We assessed the dynamic CECT findings obtained from 96 patients who underwent hepatectomy for HCC and evaluated the relationship between dynamic CECT findings and immunoscores. For validation, we assessed the treatment effects on 81 nodules using the Response Evaluation Criteria in Solid Tumors in another cohort of 41 patients who received combined immunotherapy with atezolizumab and bevacizumab (n = 27) and durvalumab and tremelizumab (n = 14). Results: HCCs with peritumoral enhancement in the arterial phase (p < 0.001) and rim APHE (p = 0.009) were associated with the immunoscore in univariate linear regression analysis and peritumoral enhancement in the arterial phase (p = 0.004) in multivariate linear regression analysis. The time to nodular progression in HCCs with peritumoral enhancement in the arterial phase was significantly longer than that in HCCs without this feature (p < 0.001). Conclusions: We identified HCCs with peritumoral enhancement in the arterial phase as a noninvasive imaging biomarker to predict immune-inflamed HCC with a high immunoscore tendency. These HCCs were most likely to respond to combined immunotherapy.2025年03月, Cancers, 17(6) (6), 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but can give rise to immune-related adverse events such as ICI-related diabetes mellitus (DM). CASE PRESENTATION: We herein present the case of a 59-year-old Japanese man with malignant melanoma who developed ICI-related DM after 18 months of nivolumab treatment. He experienced marked hyperglycemia and diabetic ketoacidosis without a personal or family history of diabetes. Laboratory findings revealed initial preservation of insulin secretion but a rapid decline in C-peptide levels in the absence of islet autoantibodies. He was therefore diagnosed with ICI-related DM. This case fulfilled the criteria for fulminant type 1 DM but lacked the typical human leukocyte antigen alleles associated with conventional type 1 diabetes. No metastasis or morphological changes were apparent on CT scans of the pancreas, and magnetic resonance cholangiopancreatography did not show dilation or interruption of the main pancreatic duct. However, diffusion-weighted magnetic resonance imaging revealed high signal intensity with low apparent diffusion coefficient values in the pancreas, likely indicative of fibrosis or infiltration of inflammatory cells. DISCUSSION: This case underscores that ICI-related DM should be considered a potential immune-related adverse event as well as pointing to the benefit of diffusion-weighted imaging for assessment of pancreatic involvement at an early stage of the disease.2025年01月, Hormones (Athens, Greece), 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Focal nodular hyperplasia (FNH)-like lesions are hyperplastic formations in patients with micronodular cirrhosis and a history of alcohol abuse. Although pathologically similar to hepatocellular carcinoma (HCC) lesions, they are benign. As such, it is important to develop methods to distinguish between FNH-like lesions and HCC. AIM: To evaluate diagnostically differential radiological findings between FNH-like lesions and HCC. METHODS: We studied pathologically confirmed FNH-like lesions in 13 patients with alcoholic cirrhosis [10 men and 3 women; mean age: 54.5 ± 12.5 (33-72) years] who were negative for hepatitis-B surface antigen and hepatitis-C virus antibody and underwent dynamic computed tomography (CT) and magnetic resonance imaging (MRI), including superparamagnetic iron oxide (SPIO) and/or gadoxetic acid-enhanced MRI. Seven patients also underwent angiography-assisted CT. RESULTS: The evaluated lesion features included arterial enhancement pattern, washout appearance (low density compared with that of surrounding liver parenchyma), signal intensity on T1-weighted image (T1WI) and T2-weighted image (T2WI), central scar presence, chemical shift on in- and out-of-phase images, and uptake pattern on gadoxetic acid-enhanced MRI hepatobiliary phase and SPIO-enhanced MRI. Eleven patients had multiple small lesions (< 1.5 cm). Radiological features of FNH-like lesions included hypervascularity despite small lesions, lack of "corona-like" enhancement in the late phase on CT during hepatic angiography (CTHA), high-intensity on T1WI, slightly high- or iso-intensity on T2WI, no signal decrease in out-of-phase images, and complete SPIO uptake or incomplete/partial uptake of gadoxetic acid. Pathologically, similar to HCC, FNH-like lesions showed many unpaired arteries and sinusoidal capillarization. CONCLUSION: Overall, the present study showed that FNH-like lesions have unique radiological findings useful for differential diagnosis. Specifically, SPIO- and/or gadoxetic acid-enhanced MRI and CTHA features might facilitate differential diagnosis of FNH-like lesions and HCC.2025年01月, World journal of gastroenterology, 31(2) (2), 98031 - 98031, 英語, 国際誌研究論文（学術雑誌）
- Cine-magnetic resonance imaging (MRI) has been used to track respiratory-induced motion of the liver and tumor and assist in the accurate delineation of tumor volume. Recent developments in compressed sensitivity encoding (SENSE; CS) have accelerated temporal resolution while maintaining contrast resolution. This study aimed to develop and assess hepatobiliary phase (HBP) cine-MRI scans using CS. Phantom was imaged using cine-MRI and signal intensity (SI) and contrast ratio (CR) measured to determine the optimal flip-angle turbo field echo (TFE) prepulse delay. We performed cine-MRI in 20 patients for one minute, with images taken every 0.5 s after administration of gadoxetic acid contrast agent. Acquired images had three different acceleration factors (SENSE, CS without denoising [CS-no], and CS with strong denoising [CS-strong]). The image quality of the HBP cine MRI was quantitatively and qualitatively analyzed. In the phantom study, a flip angle of 30 °and TFE prepulse delay of 150 ms were optimal for clinical imaging. In a clinical study, CS-strong showed the highest signal-to-noise ratio and comparable contrast ratio among the three sequences. The CS-strong group showed a significantly higher image quality (P < 0.01), except for motion smoothness (P = 0.11). CS with denoising improved the tumor-to-liver contrast and image quality in high-temporal-resolution HBP cine MRI.2024年12月, Scientific reports, 14(1) (1), 31347 - 31347, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Focal pancreatic parenchymal atrophy (FPPA) and upstream pancreatic atrophy (UPA) may indicate the presence of early pancreatic cancer. In early pancreatic cancer, the tumor occasionally spreads laterally along the main pancreatic duct, presenting challenges in determining the extent of surgical resection. This study aimed to investigate the association of pancreatic atrophy pattern and intraductal cancer extension. METHODS: Thirty-two patients with early-stage pancreatic cancer who underwent surgery at five participating centers were enrolled. Pancreatic atrophy was defined as the narrowing of parenchyma compared to the surrounding parenchyma and was classified as either FPPA (partial atrophy surrounding the pancreatic duct stenosis) or UPA (global atrophy caudal to the site of duct stenosis). Intraductal cancer extension was defined as an extension exceeding 10 mm. RESULTS: Preoperative computed tomography revealed FPPA, UPA, and no parenchymal atrophy in 13, 13, and 6 patients. Cases with FPPA or UPA showed significantly longer cancer extensions than those without atrophy (P = 0.005 and P = 0.03, respectively). Intraductal cancer extension was present in all but one case of FPPA. 69% (9/13) of the cases with UPA showed intraductal cancer extension, whereas cases without atrophy showed no intraductal cancer extension. Importantly, two patients with FPPA or UPA showed positive resection margins during surgery and three patients with FPPA or UPA showed recurrence in the remnant pancreas. CONCLUSIONS: The presence of FPPA and UPA indicates lateral cancer extension in early-stage pancreatic cancer. Preoperative assessment of the pancreatic parenchyma may provide valuable insights for determining the extent of surgical resection.2024年12月, Journal of gastroenterology, 59(12) (12), 1133 - 1142, 英語, 国内誌研究論文（学術雑誌）
- Introduction: Immunotherapy is the first-line treatment for intermediate-advanced stage hepatocellular carcinoma (HCC), although its outcomes vary. This study aimed to identify imaging biomarkers of immunotherapy susceptibility linked to gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) and immune phenotypes, particularly immune-excluded phenotypes, with a tumor immune barrier.Methods: We performed immunohistochemical staining with a CD8+ antibody, and samples were classified into immune-inflamed, -intermediate, -excluded, and -ignored phenotypes. We assessed EOB-MRI findings obtained from 104 patients who underwent hepatectomy for HCC and evaluated the relationship between MRI findings and immune phenotype. Spatial transcriptome analysis of tumor tissues in each immune phenotype was performed to characterize the MRI findings. For validation, we analyzed the treatment effect on 60 nodules in another cohort of 27 patients who received combined immunotherapy using anti-programmed death-ligand 1 and anti-vascular endothelial growth factor (VEGF) antibodies.Results: HCCs with rim arterial phase hyperenhancement (APHE) (odds ratio [OR] 17.3 P=0.009), peritumoral enhancement on the arterial phase (OR 8.6, P<0.004), and intermediate intensity on the hepatobiliary phase (HBP) measured with a visual 3-point scale (OR 28.2, P=0.002) were associated with immune-excluded phenotype, where tumors tended to be larger and of the single nodular type with extranodular growth and confluent multinodular rather than the simple nodular type. Spatial transcriptome analysis revealed a spatial relationship among cytotoxic T lymphocytes, VEGF signals, and cancer-associated fibroblasts at the tumor-invasive margins in this phenotype. From the validation study, nodules with any one of these three imaging findings had a significantly prolonged time to-nodular progression (P=0.007, median not reached vs. 226 days).Conclusion: HCCs with rim APHE, peritumoral enhancement on arterial phase, and intermediate intensity on HBP with visual 3-point scale could be non-invasive biomarkers to predict the immune-excluded phenotype with tumor immune barrier. These HCCs were most likely to respond to the combined immunotherapy.S. Karger AG, 2024年11月, Liver Cancer, 1 - 26研究論文（学術雑誌）
- BACKGROUND AND AIMS: EUS-guided hepaticogastrostomy (EUS-HGS) carries a risk of serious adverse events (AEs). A newly designed, partially covered laser-cut stent with antimigration anchoring hooks and a thin tapered tip (7.2F), called a Hook stent, has been developed to prevent serious AEs associated with EUS-HGS. The present prospective multicenter clinical trial evaluated the efficacy and safety of the Hook stent for EUS-HGS after failure of ERCP in patients with unresectable malignant biliary obstruction. METHODS: The primary endpoint was the rate of clinical success, and the secondary endpoints were the rates of technical success, AEs, recurrent biliary obstruction (RBO), procedure success without using a tract dilation device, re-intervention for RBO, time to RBO (TRBO) and overall survival (OS). RESULTS: A total of 38 patients underwent EUS-HGS using the Hook stent. Its technical and clinical success rates in patients undergoing EUS-HGS were 100% and 92.1%, respectively. The procedure success rate without using a tract dilation device was 94.7%. Four (10.5%) patients developed early AEs, but there were no severe AEs such as stent migration. RBO developed in 26.3% of patients. Re-intervention for RBO had a 100% success rate. The median TRBO was not reached, and the median OS was 191 days. CONCLUSIONS: EUS-HGS using the Hook stent demonstrated a high clinical success rate, a low rate of early AEs, and an acceptable stent patency. The Hook stent is safe and feasible for use in patients undergoing EUS-HGS.2024年11月, Gastrointestinal endoscopy, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Preoperative recognition of the anatomy of caudate biliary branches is important for the safe and complete resection of perihilar cholangiocarcinoma (PHC). In the present study, we identified these branches using an endoscopic nasobiliary drainage tube (ENBD). METHODS: Between January 2012 and October 2022, 89 patients with suspected PHC underwent computed tomographic (CT) cholangiography through ENBD and caudate biliary branching patterns were examined. Multidetector raw CT (MDCT) scans on 85 patients with PHC without biliary drainage were also investigated. The caudate biliary branches detected by each modality were evaluated. RESULTS: ENBD-CT cholangiography detected 206 caudate branches (2.44 branches/patient), while MDCT identified 62 branches (0.78 branches/patient). ENBD-CT cholangiography showed that 89 caudate branches drained into the left hepatic duct (LHD), 87 into the posterior hepatic duct (Bpost), and 30 into the right hepatic duct. LHD and Bpost were the common roots of the caudate branches. Some branches (20%) joined the contralateral hepatic duct across the left-right border, but not the anterior hepatic duct or infraportal-type Bpost. CONCLUSIONS: ENBD-CT cholangiography clearly showed the caudate biliary branches in patients with PHC after biliary drainage.2024年09月, Journal of hepato-biliary-pancreatic sciences, 31(11) (11), 809 - 815, 英語, 国内誌研究論文（学術雑誌）
- PURPOSE: To compare the image quality, inter-reader agreement, and diagnostic capability for muscle-invasive bladder cancer (MIBC) of the reconstructed images in sections orthogonal to the bladder tumor obtained by 3D Dynamic contrast-enhanced (DCE)-MRI using the Golden-angle Radial Sparse Parallel (GRASP) technique with the images directly captured using the Cartesian sampling. MATERIALS AND METHODS: This study involved 68 initial cases of bladder cancer examined with DCE-MRI (GRASP: n = 34, Cartesian: n = 34) at 3 Tesla. Four radiologists conducted qualitative evaluations (overall image quality, absence of motion artifact, absence of streak artifact, and tumor conspicuity) using a five-point Likert scale (5 = Excellent/None) and quantitative signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) measurements. The areas under the receiver-operating characteristic curves (AUCs) for the Vesical Imaging-Reporting and Data System (VI-RADS) DCE score for MIBC assessment were calculated. Inter-reader agreement was also assessed. RESULTS: GRASP notably enhanced overall image quality (pooled score: GRASP 4 vs. Cartesian 3, P < 0.0001), tumor conspicuity (5 vs. 3, P < 0.05), SNR (Median 38.2 vs. 19.0, P < 0.0001), and CNR (7.9 vs. 6.0, P = 0.005), with fewer motion artifacts (5 vs. 3, P < 0.0001) and minor streak artifacts (5 vs. 5, P > 0.05). Although no significant differences were observed, the GRASP group tended to have higher AUCs for MIBC (pooled AUCs: 0.92 vs. 0.88) and showed a trend toward higher inter-reader agreement (pooled kappa-value: 0.70 vs. 0.63) compared to the Cartesian group. CONCLUSIONS: Using the GRASP for 3D DCE-MRI, the reconstructed images in sections orthogonal to the bladder tumor achieved higher image quality and improve the clinical work flow, compared to the images directly captured using the Cartesian. GRASP tended to have higher diagnostic ability for MIBC and showed a trend toward higher inter-reader agreement compared to the Cartesian.2024年08月, Japanese journal of radiology, 英語, 国内誌研究論文（学術雑誌）
- PURPOSE: To compare the utility of thin-slice fat-suppressed single-shot T2-weighted imaging (T2WI) with deep learning image reconstruction (DLIR) and conventional fast spin-echo T2WI with DLIR for evaluating pancreatic protocol. METHODS: This retrospective study included 42 patients (mean age, 70.2 years) with pancreatic cancer who underwent gadoxetic acid-enhanced MRI. Three fat-suppressed T2WI, including conventional fast-spin echo with 6 mm thickness (FSE 6 mm), single-shot fast-spin echo with 6 mm and 3 mm thickness (SSFSE 6 mm and SSFSE 3 mm), were acquired for each patient. For quantitative analysis, the SNRs of the upper abdominal organs were calculated between images with and without DLIR. The pancreas-to-lesion contrast on DLIR images was also calculated. For qualitative analysis, two abdominal radiologists independently scored the image quality on a 5-point scale in the FSE 6 mm, SSFSE 6 mm, and SSFSE 3 mm with DLIR. RESULTS: The SNRs significantly improved among the three T2-weighted images with DLIR compared to those without DLIR in all patients (P < 0.001). The pancreas-to-lesion contrast of SSFSE 3 mm was higher than those of the FSE 6 mm (P < 0.001) and tended to be higher than SSFSE 6 mm (P = 0.07). SSFSE 3 mm had the highest image qualities regarding pancreas edge sharpness, pancreatic duct clarity, and overall image quality, followed by SSFSE 6 mm and FSE 6 mm (P < 0.0001). CONCLUSION: SSFSE 3 mm with DLIR demonstrated significant improvements in SNRs of the pancreas, pancreas-to-lesion contrast, and image quality more efficiently than did SSFSE 6 mm and FSE 6 mm. Thin-slice fat-suppressed single-shot T2WI with DLIR can be easily implemented for pancreatic MR protocol.2024年06月, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: This study aimed to examine whether the coefficient of variation (CV) in the hepatobiliary-phase (HBP) of Gd-EOB-DTPA-MRI could be an independent predictive factor for tumor progression. METHODS: Patients who underwent Gd-EOB-DTPA-MRI before Atezolizumab/bevacizumab therapy at six affiliated institutions between 2018 and 2022 were included. CV for each patient was calculated as the mean value for up to five tumors larger than 10 mm, and CV of the whole tumor was calculated using LIFEx software. The tumor response was evaluated within 6-10 weeks. The primary endpoint was to investigate the predictive factors, including CV, related to tumor progression using logistic regression analysis. The secondary endpoints were tumor response rate and progression-free survival (PFS) based on CV. RESULTS: Of the 46 enrolled patients, 13 (28.3%) underwent early progressive disease. Multivariate analysis revealed that a high CV (≥0.22) was an independent predictive factor for tumor progression (p = 0.043). Patients with a high CV had significantly frequent PD than those with a low CV (43.5 vs. 13.0%, p = 0.047). Patients with a high CV tended to have shorter PFS than those with a low CV (3.5 vs. 6.7 months, p = 0.071). CONCLUSION: Quantitative analysis using CV in the HBP of Gd-EOB-DTPA-MRI may be useful for predicting tumor progression for atezolizumab/bevacizumab therapy.2024年06月, Cancers, 16(12) (12), 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: This study examines the hepatic extracellular volume fraction (ECV) disparity between the left and right lobes (ECV_left and ECV_right) in patients with chronic thromboembolic pulmonary hypertension (CTEPH), its association with right heart catheterization (RHC) metrics, and with intolerance to increased pulmonary hypertension (PH)-targeted medication dosages. METHODS: We retrospectively analyzed 72 CTEPH-diagnosed patients who underwent equilibrium-phase abdominal dual-energy CT (DECT) and RHC. Hepatic ECVs, derived from DECT's iodine maps using circular regions of interest in the liver and aorta, were correlated with RHC parameters via Spearman's rank correlation and lobe differences through the Wilcoxon signed-rank test. Logistic regression assessed cases with ECV_left exceeding ECV_right by > 0.05, while receiver operating characteristic curve analysis gauged ECVs' predictive power for medication intolerance. RESULTS: Of the 72 patients (57 females; median age 69), ECV_total (0.24, IQR 0.20-0.27) moderately correlated with RHC parameters (rs = 0.28, -0.24, 0.3 for mean pulmonary arterial pressure, cardiac index [CI], and pulmonary vascular resistance index, respectively). ECV_left significantly surpassed ECV_right (0.25 vs. 0.22, p < 0.001), with a greater ECV_left by > 0.05 indicating notably lower CI (p < 0.001). In 27 patients on PH medication, ECV_left effectively predicted medication intolerance (AUC = 0.84). CONCLUSION: In CTEPH patients, hepatic ECV correlated with RHC metrics, where elevated left lobe ECV suggested reduced CI and potential medication intolerance.2024年05月, The international journal of cardiovascular imaging, 英語, 国際誌研究論文（学術雑誌）
- This study investigated the utility of imaging features, such as rim enhancement on contrast-enhanced CT (CECT), in predicting the prognosis of pancreatic ductal adenocarcinoma (PDAC). This retrospective study included 158 patients (84 men; mean age, 68 years) with pathologically confirmed PDAC. The following imaging features were evaluated on CECT by two radiologists: tumor size, tumor attenuation, and the presence of rim enhancement. Cox proportional hazards analysis was performed to identify the imaging and clinicopathological features for predicting disease-free survival (DFS) and overall survival (OS). Pathological features were compared with the presence of rim enhancement. Among the 158 patients, 106 (67%) underwent curative surgery (surgery group) and 52 (33%) received conservative treatment (non-surgery group). Rim enhancement was observed more frequently in the non-surgery group than in the surgery group (44% vs. 20%; p < 0.001). Rim enhancement showed significant associations with shorter DFS and OS in the surgery group (hazard ratios (HRs), 3.03 and 2.99; p < 0.001 and p = 0.003, respectively), whereas tumor size showed significant associations with shorter OS (HR per 1 mm increase, 1.08; p < 0.001). PDACs with rim enhancement showed significant associations with higher histological tumor grades (p < 0.001). PDAC with rim enhancement on CECT could predict poorer prognosis and more aggressive tumor grades.MDPI AG, 2024年04月, Diagnostics, 14(8) (8), 782 - 782研究論文（学術雑誌）
- BACKGROUND: Focal parenchymal atrophy and main pancreatic duct (MPD) dilatation have been identified as early signs of pancreatic ductal adenocarcinoma. However, limited evidence exists regarding their temporal progression due to previous study limitations with restricted case numbers. OBJECTIVE: To ascertain a more precise frequency assessment of suspicious pancreatic ductal adenocarcinoma findings as well as delineate the temporal progression of them. METHODS: A multicenter retrospective study was conducted on patients diagnosed with pancreatic ductal adenocarcinoma between 2015 and 2021. We included patients who had undergone at least one computed tomography (CT) scan ≥6 months before diagnosing pancreatic ductal adenocarcinoma. The temporal progression of suspicious pancreatic ductal adenocarcinoma findings on CT was investigated. RESULTS: Out of 1832 patients diagnosed with pancreatic ductal adenocarcinoma, 320 had a previous CT before their diagnosis. Suspicious pancreatic ductal adenocarcinoma findings were detected in 153 cases (47.8%), with focal parenchymal atrophy (26.6%) being the most common followed by MPD dilatation (11.3%). Focal parenchymal atrophy was the earliest detectable sign among all suspicious findings and became visible on average 2.7 years before diagnosis, and the next most common, MPD dilatation, 1.1 years before diagnosis. Other findings, such as retention cysts, were less frequent and appeared around 1 year before diagnosis. Focal parenchymal atrophy followed by MPD dilatation was observed in 10 patients but not in reverse order. Focal parenchymal atrophy was more frequently detected in the pancreatic body/tail. No significant relationship was found between the pathological pancreatic ductal adenocarcinoma differentiation or tumor stage and the time course of the CT findings. All cases of focal parenchymal atrophy progressed just prior to diagnosis, and the atrophic area was occupied by tumor at diagnosis. Main pancreatic duct dilatation continued to progress until diagnosis. CONCLUSION: This large-scale study revealed that the temporal progression of focal parenchymal atrophy is the earliest detectable sign indicating pancreatic ductal adenocarcinoma. These results provide crucial insights for early pancreatic ductal adenocarcinoma detection.2024年03月, United European gastroenterology journal, 英語, 国際誌研究論文（学術雑誌）
- AIM: The IMbrave150 trial revealed that atezolizumab plus bevacizumab (AtezoBv) showed a higher objective response rate (ORR) in patients with advanced hepatocellular carcinoma (HCC). Although conversion therapy after AtezoBv has been recently reported, markers predictive of its efficacy, particularly radiological imaging markers, have not yet been identified. The present study focused on tumor morphological appearance on radiological imaging and evaluated whether it could be associated with AtezoBv efficacy. METHODS: Ninety-five intrahepatic lesions in 74 patients who were given AtezoBv for advanced HCC were recruited for evaluation. The lesions were divided into two groups, simple nodular (SN group) and non-simple nodular (non-SN group), based on the gross morphology on pretreatment imaging, and retrospectively evaluated for treatment response and other relevant clinical outcomes. RESULTS: Assessing the size of individual tumors after treatment, waterfall plots showed that tumor shrinkage in the non-SN group including 56 lesions was higher than that in the SN group comprising 39 lesions. The ORR was significantly higher in the non-SN group (39.3% vs. 15.4%, p = 0.012). Additionally, the median time to nodular progression was longer in the non-SN group (21.0 months vs. 8.1 months, p = 0.119) compared to the SN group. Six patients with non-SN lesions underwent sequential local therapy. CONCLUSIONS: Atezolizumab plus bevacizumab may show increased therapeutic efficacy in patients with tumors with a higher potential for aggressive oncological behavior, such as non-SN lesions. Treatment strategies focusing on conversion therapy may be crucial in patients with non-SN lesions.2024年02月, Hepatology research : the official journal of the Japan Society of Hepatology, 英語, 国際誌研究論文（学術雑誌）
- (公社)日本医学放射線学会, 2024年02月, Japanese Journal of Radiology, 42(Suppl.) (Suppl.), 32 - 32, 日本語仙骨に発生した褐色脂肪腫の1例
- INTRODUCTION: The usefulness of gadolinium-ethoxybenzyl diethylenetriamine pentaacetate acid-enhanced magnetic resonance imaging (EOB-MRI) in assessing the functional future remnant liver volume (fFRLV) to predict post-hepatectomy liver failure (PHLF) has been previously reported. Herein, we evaluated the efficacy of this technique in patients with hepatocellular carcinoma (HCC) with a major portal vein tumor thrombus (PVTT). METHODS: This study included 21 patients with PVTT in the ipsilateral first-order branch (Vp3) and 30 patients with PVTT in the main trunk/contralateral branch (Vp4). To evaluate fFRLV, the signal intensity (SI) of the remnant liver was determined on T1-weighted images, using both conventional and newly developed methods. The fFRLV was calculated using the SI of the remnant liver and muscle, remnant liver volume, and body surface area. Preoperative factors predicting PHLF (≥grade B) in HCC patients with Vp3/4 PVTT were evaluated. RESULTS: In the Vp3 group, we found fFRLV AUCs above 0.70 (AUC = 0.875, 0.750) using EOB-MRI results calculated using either the plot or whole method. None of the parameters in the Vp4 group had an AUC greater than 0.70. CONCLUSION: The fFRLV calculated by EOB-MRI using the whole method can be as useful as the conventional method in predicting PHLF (≥grade B) for HCC patients with Vp3 PVTT.2024年01月, Digestive surgery, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: Leiomyosarcoma of the inferior vena cava is associated with poor prognosis. Complete resection is the only curative treatment. We present a patient with this disease in whom cine magnetic resonance imaging was valuable in selecting the surgical strategy and mitigating invasiveness. CASE PRESENTATION: A 68-year-old woman presented with right-sided abdominal pain. Computed tomography revealed an 86 mm tumor in the right retroperitoneal space that extended into the inferior vena cava and reached superiorly to the right atrium. Percutaneous needle biopsy confirmed leiomyosarcoma. Cine magnetic resonance imaging demonstrated no adhesions between the tumor and the upper segment of inferior vena cava wall, nor with the right atrial wall, indicating resectability. Radical tumor resection was successfully performed without requiring thoracotomy. CONCLUSION: Cine magnetic resonance imaging appears to be useful in inferior vena cava leiomyosarcoma for evaluating adhesions between the tumor and vessel wall.2024年01月, IJU case reports, 7(1) (1), 30 - 33, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2024年01月, 日本インターベンショナルラジオロジー学会雑誌, 38(3) (3), 166 - 175, 日本語
- XMLink, 2024年, Korean Journal of Radiology, 25(1) (1), 24 - 24研究論文（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2023年10月, 日本インターベンショナルラジオロジー学会雑誌, 38(1) (1), 16 - 23, 日本語
- (一社)日本内分泌学会, 2023年10月, 日本内分泌学会雑誌, 99(2) (2), 561 - 561, 日本語Bilateral Suppressionを呈したアルドステロン産生腺腫の一例
- 2023年10月, Annals of surgical oncology, 30(11) (11), 6613 - 6614, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Abundant collagen deposition is a hallmark of pancreatic ductal adenocarcinomas (PDACs). This study clarified the interactive relationship between tumor-stromal collagen, molecular and immune characteristics, and tumor pr ogression in human PDAC. METHODS: We performed a comprehensive examination using an integrative molecular pathological epidemiology database on 169 cases with resected PDAC . The amount of tumor-stromal collagen was quantified through digital imaging analysis for Elastica van Gieson-stained whole-section tumor slides. We analyzed the association of tumor-stromal collagen with gene alterations (KRAS, TP53, CDKN2A/p16, and SMAD4), immune parameters (CD4+ tumor-infiltrating lymphocytes [TILs], CD8+ TILs, FOXP3+ TILs, and tertiary lymphoid structures), and patient prognosis. RESULTS: Low amounts of tumor-stromal collagen were associated with poor differentiation (multivariable OR = 3.82, 95%CI = 1.41-12.2, P = 0.008) and CDKN2A/p16 alteration (OR [95%CI] = 2.06 [1.08-4.02], P = 0.03). Tumors with low collagen levels had shorter overall survival (HR [95%CI] = 2.38 [1.59-3.56], P < 0.0001). In the S-1 and gemcitabine (GEM) treatment groups, low tumor-stromal collagen was linked to poor prognosis of patients with PDAC (S-1 group: multivariable HR [95%CI] = 2.76 [1.36-5.79], P = 0.005; GEM group: multivariate HR [95%CI] = 2.91 [1.34-6.71], P = 0.007). Additionally, low amounts of tumor-stromal collagen were also linked to low levels of CD4+ TILs (P = 0.046), CD8+ TILs (P = 0.09), and tertiary lymphoid structures (P = 0.001). CONCLUSIONS: Tumor-stromal collagen deposition may play a crucial role in modulating tumor-immune microenvironment and determining response to adjuvant chemotherapy and patient survival outcomes.2023年10月, Journal of gastroenterology, 58(10) (10), 1055 - 1067, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Few reports have discussed the association between total tumor volume (TTV) and prognosis in patients with colorectal liver metastases (CRLM). The present study aimed to evaluate the usefulness of TTV for predicting recurrence-free survival and overall survival (OS) in patients receiving initial hepatic resection or chemotherapy, and to investigate the value of TTV as an indicator for optimal treatment selection for patients with CRLM. PATIENTS AND METHODS: This retrospective cohort study included patients with CRLM who underwent hepatic resection (n = 93) or chemotherapy (n = 78) at the Kobe University Hospital. TTV was measured using 3D construction software and computed tomography images. RESULTS: A TTV of 100 cm3 has been previously reported as a significant cut-off value for predicting OS of CRLM patients receiving initial hepatic resection. For patients receiving hepatic resection, the OS for those with a TTV ≥ 100 cm3 was significantly reduced compared with those with a TTV < 100 cm3. For patients receiving initial chemotherapy, there were no significant differences between the groups divided according to TTV cut-offs. Regarding OS of patients with TTV ≥ 100 cm3, there was no significant difference between hepatic resection and chemotherapy (p = 0.160). CONCLUSIONS: TTV can be a predictive factor of OS for hepatic resection, unlike for initial chemotherapy treatment. The lack of significant difference in OS for CRLM patients with TTV ≥ 100 cm3, regardless of initial treatment, suggests that chemotherapeutic intervention preceding hepatic resection may be indicated for such patients.2023年10月, Annals of surgical oncology, 30(11) (11), 6603 - 6610, 英語, 国際誌研究論文（学術雑誌）
- To develop and investigate the feasibility of sub-second temporal resolution volumetric T1-weighted four-dimensional (4D-) MRI in comparison with 4D-CT for respiratory-correlated motion assessment using an MRI/CT-compatible phantom. Sub-second high temporal resolution (0.5 s) gradient-echo T1-weighted 4D-MRI was developed using a volumetric acquisition scheme with compressed sensing. An MRI/CT-compatible motion phantom (simulated liver tumor) with three sinusoidal movements of amplitudes and two respiratory patterns was introduced and imaged with 4D-MRI and 4D-CT to investigate the geometric accuracy of the target movement. The geometric accuracy, including centroid position, volume, similarity index of dice similarity coefficient (DSC), and Hausdorff distance (HD), was systematically evaluated. Proposed 4D-MRI achieved a similar geometric accuracy compared with 4D-CT regarding the centroid position, volume, and similarity index. The observed position differences of the absolute average centroid were within 0.08 cm in 4D-MRI and 0.03 cm in 4D-CT, less than the 1-pixel resolution for each modality. The observed volume difference in 4D-MRI/4D-CT was within 0.73 cm3 (4.5%)/0.29 cm3 (2.1%) for a large target and 0.06 cm3 (11.3%)/0.04 cm3 (11.6%) for a small target. The observed DSC values for 4D-MRI/4D-CT were at least 0.93/0.95 for the large target and 0.83/0.84 for the small target. The maximum HD values were 0.25 cm/0.31 cm for the large target and 0.21 cm/0.15 cm for the small target. Although 4D-CT potentially exhibit superior numerical accuracy in phantom studies, the proposed high temporal resolution 4D-MRI demonstrates sub-millimetre geometric accuracy comparable to that of 4D-CT. These findings suggest that the 4D-MRI technique is a viable option for characterizing motion and generating phase-dependent internal target volumes within the realm of radiotherapy.2023年09月, Scientific reports, 13(1) (1), 15685 - 15685, 英語, 国際誌研究論文（学術雑誌）
- AIM: To determine risk factors associated with hepatocellular carcinoma (HCC) development following direct-acting antiviral (DAA) therapy. METHODS: We enrolled patients with chronic hepatitis C who underwent direct-acting antiviral therapy and achieved sustained virologic response at 12 weeks between 2012 and 2018. Subsequently, patients were followed up. The primary endpoint was the development of HCC or the date of the last follow up when the absence of HCC was confirmed. Uni- and multivariate Cox proportional hazards models were used to identify factors contributing to HCC development, including gadoxetic acid-enhanced magnetic resonance imaging findings. The cumulative incidence rates of HCC development were calculated using the Kaplan-Meier method, and differences between groups were assessed using the log-rank test. RESULTS: The final study cohort comprised 482 patients (median age 70.5 years; 242 men). The median follow-up period was 36.8 months. Among 482 patients, 96 developed HCC (19.9%). The 1-, 3-, and 5-year cumulative rates of HCC development were 4.9%, 18.6%, and 30.5%, respectively. Multivariate analysis revealed that age, male sex, history of HCC, and hepatobiliary phase hypointense nodules without arterial phase hyperenhancement were independent risk factors significantly associated with HCC development (p < 0.001-0.04). The highest risk group included patients with both a history of HCC and the presence of hepatobiliary phase hypointense nodules without arterial phase hyperenhancement (the 1- and 3-year cumulative HCC development rates were 14.2% and 62.2%, respectively). CONCLUSION: History of HCC and presence of hepatobiliary phase hypointense nodules without arterial phase hyperenhancement were strong risk factors for HCC development following direct-acting antiviral therapy.2023年09月, Hepatology research : the official journal of the Japan Society of Hepatology, 英語, 国際誌研究論文（学術雑誌）
- 2023年09月, Annals of surgical oncology, 30(9) (9), 5790 - 5791, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Sarcopenia, defined as a loss of skeletal muscle mass and quality, is found in 30-65% of patients with pancreatic ductal adenocarcinoma (PDAC) at diagnosis, and is a poor prognostic factor. However, it is yet to be evaluated why sarcopenia is associated with poor prognosis. Therefore, this study elucidated the tumor characteristics of PDAC with sarcopenia, including driver gene alterations and tumor microenvironment. PATIENTS AND METHODS: We retrospectively analyzed 162 patients with PDAC who underwent pancreatic surgery between 2008 and 2017. We defined sarcopenia by measuring the skeletal muscle mass at the L3 level using preoperative computed tomography images and evaluated driver gene alteration (KRAS, TP53, CDKN2A/p16, and SMAD4) and tumor immune (CD4+, CD8+, and FOXP3+) and fibrosis status (stromal collagen). RESULTS: In localized-stage PDAC (stage ≤ IIa), overall survival (OS) and recurrence-free survival were significantly shorter in the sarcopenia group than in the non-sarcopenia group (2-year OS 89.7% versus 59.1%, P = 0.03; 2-year RFS 74.9% versus 50.0%, P = 0.02). Multivariate analysis revealed that sarcopenia was an independent poor prognostic factor in localized-stage PDAC. Additionally, tumor-infiltrating CD8+ T cells in the sarcopenia group were significantly less than in the non-sarcopenia group (P = 0.02). However, no difference was observed in driver gene alteration and fib.rotic status. These findings were not observed in advanced-stage PDAC (stage ≥ IIb). CONCLUSIONS: Sarcopenia was associated with a worse prognosis and decreased tumor-infiltrating CD8+ T cells in localized-stage PDAC. Sarcopenia may worsen a patient's prognosis by suppressing local tumor immunity.2023年09月, Annals of surgical oncology, 30(9) (9), 5776 - 5787, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: This study aimed to characterize the clinical and imaging findings of intraductal oncocytic papillary neoplasm of the pancreas (IOPN-P) compared to those of intraductal papillary mucinous adenoma/carcinoma (IPMA/IPMC). METHODS: This multi-institutional retrospective study reviewed the clinical, imaging, and pathological findings of 21 patients with pathologically proven IOPN-P. Twenty-one computed tomography (CT) and magnetic resonance imaging, and seven 18F-fluorodeoxyglucose (FDG)-positron emission tomography were performed before surgery. The following findings were evaluated: preoperative blood test results, lesion size and location, pancreatic duct diameter, contrast-enhancement effect, bile duct and peripancreatic invasion, maximum standardized uptake (SUVmax) value, and pathological stromal invasion. RESULTS: Serum carcinoembryonic antigen (CEA) and cancer antigen 19-9 (CA19-9) levels were significantly higher in the IPMN/IPMC group than in the IOPN-P group. Except in one patient, IOPN-P showed multifocal cystic lesions with solid components or a tumor in the main pancreatic duct (MPD) with dilatation. IOPN-P had a higher frequency of solid parts and a lower frequency of downstream MPD dilatation than IPMA. IPMC showed smaller overall cyst size, more radiological peripancreatic invasion, and worse recurrence-free and overall survival than IOPN-P. The average SUVmax value of IOPN-P was 7.5. Pathologically, 17 of the 21 IOPN-Ps had a malignant component, and six showed stromal invasion. CONCLUSION: IOPN-P shows cystic-solid lesions similar to IPMC but has lower serum CEA and CA19-9 levels, larger overall cyst size, lower frequency of peripancreatic invasion, and more favorable prognosis than IPMC. Moreover, the high FDG uptake by IOPN-Ps may be a characteristic finding of this study.2023年08月, Abdominal radiology (New York), 48(8) (8), 2483 - 2493, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: This study aimed to investigate the impact of transarterial embolization (TAE) on macrophage polarization and the modulatory effect of lenvatinib in combination with TAE in a rat hepatocellular carcinoma model. MATERIALS AND METHODS: A rat N1S1-bearing orthotopic model was subjected to TAE and administered 5 mg/kg of lenvatinib. CD8+, CD68+, and CD206+ cells were examined in four cohorts: sham (n=5), lenvatinib (n=5), TAE (n=5), and a combination of TAE and lenvatinib (n=5). Transcriptome analysis was performed to assess gene expression related to macrophage polarization in the sham, TAE, and combination groups. An in vitro co-culture experiment with bone marrow-derived macrophages was performed to identify lenvatinib target in macrophage polarization. RESULTS: There were no significant differences in the number of CD8+ and CD68+ cells among the four groups. Tumor-associated macrophage positivity for CD206 was significantly higher in the TAE group (58.1 ± 20.9) than in the sham (11.2 ± 14.3, P < 0.001) and combination (27.1 ± 19.7, P = 0.003) groups. In the transcriptome analysis, compared with those in the sham group, five macrophage polarization-related genes, including St6gal1, were upregulated by more than 1.5-fold in the TAE group and downregulated by more than 1.5-fold in the combination group. The co-culture experiment showed that lenvatinib did not affect macrophages but N1S1 cells, leading to macrophage polarization. CONCLUSION: TAE induced M2 macrophage polarization. Lenvatinib administration with TAE could reprogram macrophage polarization, improving tumor immune microenvironment.2023年07月, Journal of vascular and interventional radiology : JVIR, 英語, 国際誌研究論文（学術雑誌）
- Pancreatic cancer primarily arises from microscopic precancerous lesions, such as pancreatic intraepithelial neoplasia (PanIN) and acinar-to-ductal metaplasia (ADM). However, no established method exists for predicting pancreatic precancerous conditions. Endoscopic ultrasonography (EUS) can detect changes in pancreatic parenchymal histology, including fibrosis. This study aimed to elucidate the relationship between pancreatic parenchymal EUS findings and microscopic precancerous lesions. We retrospectively analyzed 114 patients with pancreatobiliary tumors resected between 2010 and 2020 and evaluated the association between pancreatic parenchymal EUS findings and the number of PanIN, ADM, and pancreatic duct gland (PDG). Of the 114 patients, 33 (29.0%), 55 (48.2%), and 26 (22.8%) had normal EUS findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity, respectively. Multivariate analyses revealed that abnormal EUS findings were significantly associated with the frequency of PanIN (hyperechoic foci/stranding without lobularity: OR [95% CI] = 2.7 [1.0-7.3], with lobularity: 6.5 [1.9-22.5], Ptrend = 0.01) and ADM (hyperechoic foci/stranding without lobularity: 3.1 [1.1-8.2], with lobularity: 9.7 [2.6-36.3], Ptrend = 0.003) but not with PDG (hyperechoic foci/stranding without lobularity: 2.2 [0.8-5.8], with lobularity: 3.2 [1.0-10.2], Ptrend = 0.12). We observed a trend toward a significantly higher number of precancerous lesions in the following order: normal findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity. Pancreatic parenchymal EUS findings were associated with the increased frequency of PanIN and ADM. Lobularity may help predict the increased number of precancerous lesions.2023年07月, Scientific reports, 13(1) (1), 12052 - 12052, 英語, 国際誌研究論文（学術雑誌）
- The central venous port has been widely used for patients who require long-term intravenous treatments, and the number of palcement has been increasing. The Japanese Society of Interventional Radiology developed a guideline for central venous port placement and management to provide evidence-based recommendations to support healthcare providers in the decision-making process regarding the central venous port. The guideline consisted of two parts: (i) a comprehensive review of topics including preoperative preparation, techniques for placement or removal, complications, and maintenance methods and (ii) recommendations for the six clinical questions regarding blood vessels for central venous port placement, port implantation site, prophylactic antibiotic therapy, imaging guidance for puncture, disinfectant prior to accessing the central venous port, and the optimal procedure at the end of drug administration via the central venous port, generated on the basis of the rating quality of evidence by systematic review.2023年07月, Interventional radiology (Higashimatsuyama-shi (Japan), 8(2) (2), 105 - 117, 英語, 国内誌研究論文（学術雑誌）
- Transarterial chemoembolization (TACE) is performed for pancreatic neuroendocrine tumor (PanNEN) liver metastases; however, the safety and efficacy of TACE procedures, especially for patients who have undergone previous pancreatic surgery, have not been established. We reviewed 48 TACE procedures (1-6 procedures/patient) performed on 11 patients with PanNEN liver metastases, including 16 TACE procedures (4-6 procedures/patient) for 3 patients with a history of biliary-enteric anastomosis. The overall tumor objective response rate was 94%. The incidence of Clavien‒Dindo grade ≥ 2 complications was 1/16 (6%) and 1/32 (3%), and the median time to untreatable progression was 31 (14-41) and 27 (2-60) months among patients with and without a history of biliary-enteric anastomosis, respectively. Although validation is needed in future studies, our experiences have shown that TACE treatment is a viable treatment option for PanNEN liver metastases, even after biliary-enteric anastomosis with experienced teams and careful patient follow-up.2023年06月, Surgery today, 英語, 国内誌研究論文（学術雑誌）
- Japanese Society for Magnetic Resonance in Medicine, 2023年05月, Japanese Journal of Magnetic Resonance in Medicine, 43(2) (2), 76 - 78研究論文（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2023年05月, 日本インターベンショナルラジオロジー学会雑誌, 37(2) (2), 110 - 116, 日本語
- To assess the value of nonenhancing capsule by adding to enhancing capsule in gadoxetic acid-enhanced MRI (EOB-MRI) in comparison with contrast-enhanced CT (CE-CT) for diagnosing histological capsule in hepatocellular carcinoma (HCC). One-hundred fifty-one patients with HCC who underwent both CE-CT and EOB-MRI were retrospectively reviewed. Liver Imaging-Reporting and Data System (LI-RADS) v2018 imaging features, including enhancing and nonenhancing capsule were evaluated by two readers in CE-CT and EOB-MRI. Frequencies of each imaging feature were compared between CE-CT and EOB-MRI. The area under the receiver operating characteristic (AUC) curve for the diagnosis of histological capsule was compared across the following three imaging criteria: (1) enhancing capsule in CE-CT, (2) enhancing capsule in EOB-MRI, and (3) enhancing/nonenhancing capsule in EOB-MRI. Enhancing capsule in EOB-MRI was significantly less frequently depicted than that in CE-CT (p < 0.001 and = 0.016 for reader 1 and 2). Enhancing/nonenhancing capsule in EOB-MRI achieved a similar frequency of enhancing in CE-CT (p = 0.590 and 0.465 for reader 1 and 2). Adding nonenhancing capsule to enhancing capsule in EOB-MRI significantly increased AUCs (p < 0.001 for both readers) and achieved similar AUCs compared with enhancing capsule in CE-CT (p = 0.470 and 0.666 for reader 1 and 2). Adding nonenhancing capsule to the definition of capsule appearance can improve the diagnosis of capsule in EOB-MRI for the diagnosis of histological capsule in HCC and decrease discordance of capsule appearance between EOB-MRI and CE-CT.2023年04月, Scientific reports, 13(1) (1), 6113 - 6113, 英語, 国際誌研究論文（学術雑誌）
- The incidence of hepatocellular carcinoma (HCC) is still on the rise in North America and Europe and is the second leading cause of cancer-related mortality. The treatment of HCC varies, with surgery and locoregional therapy (LRT) such as radiofrequency ablation and transcatheter arterial chemoembolization, and radiation therapy being the primary treatment. Currently, systemic therapy with molecular-targeted agents and immune checkpoint inhibitors (ICIs) is becoming a major treatment option for the unresectable HCC. As the HCC after LRT or systemic therapy often remains unchanged in size and shows loss of contrast effect in contrast-enhanced CT or MRI, the response evaluation criteria in solid tumors (RECIST) and World Health Organization criteria, which are usually used to evaluate the treatment response of solid tumors, are not appropriate for HCC. The modified RECIST (mRECIST) and the European Association for the Study of the Liver (EASL) criteria were developed for HCC, with a focus on viable lesions. The latest 2018 edition of the Liver Imaging Reporting and Data System (LI-RADS) also includes a section on the evaluation of treatment response. The cancer microenvironment influences the therapeutic efficacy of ICIs. Several studies have examined the utility of gadoxetic acid-enhanced MRI for predicting the pathological and molecular genetic patterns of HCC. In the future, it may be possible to stratify prognosis and predict treatment response prior to systemic therapy by using pre-treatment imaging findings.2023年04月, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 22(2) (2), 209 - 220, 英語, 国内誌研究論文（学術雑誌）
- 医歯薬出版(株), 2023年03月, 医学のあゆみ, 284(12) (12), 941 - 944, 日本語
- PURPOSE: To investigate the added value of contrast enhancement boost (CE-boost) images in multiphasic contrast-enhanced CT (CE-CT) for diagnosing small (<20 mm) hypervascular hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This retrospective study included 69 patients (age, 74 ± 8 years; 52 men) with 70 hypervascular HCCs (<20 mm) who underwent multiphasic CE-CT (pre-contrast, late arterial phase [LAP], portal venous phase [PVP], and equilibrium phase). Two types of CE-boost images were generated by subtracting PVP from LAP (LA-PV) images and LAP from PVP (PV-LA) images to enhance the contrast effect of hepatic arterial and portal venous perfusion more selectively. Tumor-to-liver contrast-to-noise ratios (CNRs) in CE-boost images were compared with those in CE-CT images using the Wilcoxon signed-rank test. Two independent readers reviewed the imaging datasets: CE-CT alone and CE-CT with CE-boost images. The diagnostic performance of each dataset was compared using jackknife alternative free-response receiver operating characteristics (JAFROC-1). RESULTS: The tumor-to-liver CNRs in the LA-PV (6.4 ± 3.0) and PV-LA (-3.3 ± 2.1) images were greater than those in the LAP (3.2 ± 1.7) and PVP images (-1.1 ± 1.4) (p <.001 for both). The reader-averaged figures of merit were 0.751 for CE-CT alone and 0.807 for CE-CT with CE-boost images (p <.001). Sensitivities increased by adding CE-boost images for both readers (p <.001 and = 0.03), while positive predictive values were equivalent (p >.99). CONCLUSION: Adding CE-boost images to multiphasic CE-CT can improve the diagnostic accuracy and sensitivity for small hypervascular HCC by increasing the tumor-to-liver CNR.2023年03月, European journal of radiology, 160, 110696 - 110696, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Tertiary lymphoid structure (TLS) reflects an intense immune response against cancer, which correlates with favorable patient survival. However, the association of TLS with tumor-infiltrating lymphocytes (TILs) and clinical outcomes has not been investigated comprehensively in pancreatic ductal adenocarcinoma (PDAC). METHODS: We utilized an integrative molecular pathological epidemiology database on 162 cases with resected PDAC, and examined TLS in relation to levels of TILs, patient survival, and treatment response. In whole-section slides, we assessed the formation of TLS and conducted immunohistochemistry for tumor-infiltrating T cells (CD4, CD8, CD45RO, and FOXP3). As confounding factors, we assessed alterations of four main driver genes (KRAS, TP53, CDKN2A [p16], and SMAD4) using next-generation sequencing and immunohistochemistry, and tumor CD274 (PD-L1) expression assessed by immunohistochemistry. RESULTS: TLSs were found in 112 patients with PDAC (69.1%). TLS was associated with high levels of CD4+ TILs (multivariable odds ratio [OR], 3.50; 95% confidence interval [CI] 1.65-7.80; P = 0.0002), CD8+ TILs (multivariable OR, 11.0; 95% CI 4.57-29.7, P < 0.0001) and CD45RO+ TILs (multivariable OR, 2.65; 95% CI 1.25-5.80, P = 0.01), but not with levels of FOXP3+ TILs. TLS was associated with longer pancreatic cancer-specific survival (multivariable hazard ratio, 0.37; 95% CI 0.25-0.56, P < 0.0001) and favorable outcomes of adjuvant S-1-treatment. TLS was not associated with driver gene alterations but tumor CD274 negative expression. CONCLUSIONS: Our comprehensive data supports the surrogacy of TLS for vigorous anti-tumor immune response characterized by high levels of helper and cytotoxic T cells and their prognostic role.2023年03月, Journal of gastroenterology, 58(3) (3), 277 - 291, 英語, 国内誌研究論文（学術雑誌）
- OBJECTIVES: To investigate the effect of deep learning image reconstruction (DLIR) on the accuracy of iodine quantification and image quality of dual-energy CT (DECT) compared to that of other reconstruction algorithms in a phantom experiment and an abdominal clinical study. METHODS: An elliptical phantom with five different iodine concentrations (1-12 mgI/mL) was imaged five times with fast-kilovoltage-switching DECT for three target volume CT dose indexes. All images were reconstructed using filtered back-projection, iterative reconstruction (two levels), and DLIR algorithms. Measured and nominal iodine concentrations were compared among the algorithms. Contrast-enhanced CT of the abdomen with the same scanner was acquired in clinical patients. In arterial and portal venous phase images, iodine concentration, image noise, and coefficients of variation for four locations were retrospectively compared among the algorithms. One-way repeated-measures analyses of variance were used to evaluate differences in the iodine concentrations, standard deviations, coefficients of variation, and percentages of error among the algorithms. RESULTS: In the phantom study, the measured iodine concentrations were equivalent among the algorithms: within ± 8% of the nominal values, with root-mean-square deviations of 0.08-0.36 mgI/mL, regardless of radiation dose. In the clinical study (50 patients; 35 men; mean age, 68 ± 11 years), iodine concentrations were equivalent among the algorithms for each location (all p > .99). Image noise and coefficients of variation were lower with DLIR than with the other algorithms (all p < .01). CONCLUSIONS: The DLIR algorithm reduced image noise and variability of iodine concentration values compared with other reconstruction algorithms in the fast-kilovoltage-switching dual-energy CT. KEY POINTS: • In the phantom study, standard deviations and coefficients of variation in iodine quantification were lower on images with the deep learning image reconstruction algorithm than on those with other algorithms. • In the clinical study, iodine concentrations of measurement location in the upper abdomen were consistent across four reconstruction algorithms, while image noise and variability of iodine concentrations were lower on images with the deep learning image reconstruction algorithm.Springer Science and Business Media LLC, 2023年02月, European radiology, 33(2) (2), 1388 - 1399, 英語, 国際誌研究論文（学術雑誌）
- The Japanese Society of Interventional Radiology, 2023年, Interventional Radiology研究論文（学術雑誌）
- BACKGROUND AND AIM: Endoscopic ultrasonography (EUS) findings of the pancreatic parenchyma, such as hyperechoic foci/stranding and lobularity, may be associated with the severity of chronic pancreatitis (CP). However, the correlation between parenchymal EUS findings and histology remains unclear. We designed a large-scale retrospective study analyzing over 200 surgical specimens to elucidate the association between parenchymal EUS findings and histological features. METHODS: Clinical data of 221 patients with pancreatobiliary tumors who underwent preoperative EUS and pancreatic surgery between January 2010 and November 2020 were reviewed to investigate the association between parenchymal EUS findings and histological features at the pancreatic body. None of these patients met the definition of CP. RESULTS: Of the 221 patients, 87 (39.4%), 89 (40.2%), and 45 (20.4%) had normal EUS findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity, respectively. In the multivariate analyses, parenchymal EUS findings significantly correlated with histological CP findings of fibrosis, inflammation, and atrophy (hyperechoic foci/stranding without lobularity vs hyperechoic foci/stranding with lobularity, odds ratio [95% confidence interval]: 4.1 [2.2-7.9] vs 31.3 [9.3-105.6], Ptrend < 0.001; 3.9 [1.9-8.2] vs 21.8 [8.0-59.4], Ptrend < 0.001; and 4.0 [2.0-7.8] vs 22.9 [7.0-74.5], Ptrend < 0.001, respectively). Further, a trend toward higher histological grade was observed in the following order: normal findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity. CONCLUSIONS: Endoscopic ultrasonography findings of the pancreatic parenchyma may be associated with the histological conditions in CP, such as pancreatic fibrosis, inflammation, and atrophy. Lobularity reflects more severe histological conditions than does hyperechoic foci/stranding.2023年01月, Journal of gastroenterology and hepatology, 38(1) (1), 103 - 111, 英語, 国際誌研究論文（学術雑誌）
- Abstract Background Spinal fractures rarely cause hemothorax, and no treatment consensus has been reached. Conservative treatment is generally selected in cases without arterial injury, but there have been some reports of uncontrolled bleeding. Here we report a case of hemothorax caused by spinal fracture without arterial injury treated with transcatheter arterial embolization. Case presentation An 88-year-old Japanese woman with back pain was diagnosed with hemothorax due to bleeding from an unstable fracture of the tenth thoracic vertebra. Contrast-enhanced computed tomography revealed no obvious arterial injury. We performed transcatheter arterial embolization of the bilateral tenth intercostal arteries to prevent rebleeding. The hemothorax did not worsen until surgical spinal fixation 9 days post-transcatheter arterial embolization, and she was discharged 30 days after admission. Conclusion Transcatheter arterial embolization for hemothorax caused by spinal fractures without obvious arterial injury may be a useful bridge to spinal fixation.Springer Science and Business Media LLC, 2022年09月, Journal of medical case reports, 16(1) (1), 332 - 332, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Gadoxetic acid-enhanced magnetic resonance imaging (MRI) is useful in detecting liver metastases from pancreatic ductal adenocarcinoma (PDAC). However, the long examination time limits its utility in the initial workup of patients with PDAC. PURPOSE: To evaluate the incremental value of an abbreviated gadoxetic acid-enhanced MRI for the detection of liver metastases in patients with PDAC. STUDY TYPE: Retrospective. POPULATION: Patients (N = 130) with potentially resectable PDAC (women, 58 [44.6%]). FIELD STRENGTH/SEQUENCE: 1.5 T and 3 T; gradient dual-echo T1-weighted (in-phase and opposed-phase), fat-suppressed fast spin-echo T2-weighted, single-shot echo-planar diffusion-weighted, and three-dimensional fat-suppressed T1-weighted gradient-echo dynamic contrast-enhanced and hepatobiliary phase sequences, as well as contrast-enhanced computed tomography (CECT). ASSESSMENT: Three radiologists independently reviewed three different image sets to detect liver metastases: set 1, CECT alone; set 2, CECT and abbreviated MRI comprising fat-suppressed T2-weighted, diffusion-weighted, and hepatobiliary phase images; and set 3, CECT and standard gadoxetic acid-enhanced MRI. STATISTICAL TESTS: Figure of merit (FOM) was compared using the jackknife alternative free-response receiver operating characteristics, and other per-lesion and per-patient diagnostic parameters for each image set were compared using McNemar's and Fisher's test. P < 0.05 was considered statistically significant. RESULTS: A total of 43 liver metastases were identified in 13 patients. Reader-averaged FOM to detect liver metastases were significantly higher for sets 2 (0.884) and 3 (0.886) than for set 1 (0.609), while they were comparable between sets 2 and 3 (P = 0.96). The mean per-patient sensitivities, negative predictive values, and accuracies were significantly higher for sets 2 and 3 than for set 1, while those between sets 2 and 3 were not significantly different (not applicable, P > 0.99, and P > 0.99, respectively). DATA CONCLUSION: Gadoxetic acid-enhanced MRI combined with CECT had higher diagnostic performance than CECT alone for the detection of liver metastases in patients with PDAC. The incremental values were comparable for the abbreviated MRI and standard MRI. LEVEL OF EVIDENCE: 3 TECHNICAL EFFICACY: Stage 2.2022年09月, Journal of magnetic resonance imaging : JMRI, 56(3) (3), 725 - 736, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) concomitant with intraductal papillary mucinous neoplasm (IPMN) is defined as PDAC occurring apart from IPMN. This study comprehensively investigated the molecular biologic characteristics of PDAC concomitant with IPMN in major genetic alterations, tumor microenvironment, and prognosis by contrast with those of conventional PDAC. METHODS: The study retrospectively reviewed the data of 158 surgically resected PDAC patients. The driver gene alteration status (KRAS, TP53, CDKN2A, SMAD4, and GNAS) together with the immune and fibrotic status in tumor was evaluated. The prognosis of PDAC concomitant with IPMN and that of conventional PDAC also were compared. RESULTS: No statistically significant difference was found between PDAC concomitant with IPMN and conventional PDAC in the alteration frequency analysis of the major driver genes and the immune and fibrotic status in the tumor microenvironment. Overall survival and disease-free survival between patients who had PDAC concomitant with IPMN and those who had conventional PDAC did not show statistically significant differences in propensity-matched subjects. Furthermore, the co-existence of IPMN was not a poor prognostic factor in the multivariable-adjusted Cox proportional hazards model (hazard ratio, 0.95; 95 % confidence interval, 0.51-1.78). CONCLUSIONS: In this study, PDAC concomitant with IPMN had tumor characteristics similar to those of conventional PDAC in terms of the major driver gene alterations, tumor microenvironment, and prognosis.2022年08月, Annals of surgical oncology, 29(8) (8), 4924 - 4934, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: In renal cell carcinoma with inferior vena cava (IVC) thrombus, adhesion to, or invasion into, the IVC wall will often increase the level of surgical difficulty and even necessitate resection of the IVC. It will generally be difficult to perform an accurate preoperative assessment using the standard imaging modalities of contrast-enhanced computed tomography and standard magnetic resonance imaging (MRI). Cine MRI is an MRI sequence that captures motion to produce detailed information on both the anatomy and the dynamic motion. In the present study, we evaluated the accuracy of preoperative cine MRI for determining the need for IVC wall resection, with validation of the imaging findings according to the intraoperative findings. METHODS: A total of 15 patients who had undergone radical nephrectomy and tumor thrombectomy from May 2018 to April 2020 met the inclusion criteria. The primary outcome of interest was the need for IVC resection because of adhesion or invasion of a venous tumor thrombus. Cine MRI was used to evaluate the blood flow between the tumor thrombus and the IVC wall and the presence of tumor thrombus mobility during free respiration. The sensitivity and specificity were calculated for preoperative cine MRI for determining the need for IVC wall resection. The Fisher exact test was used to determine the association between intraoperative IVC wall resection and the cine MRI findings. Furthermore, receiver operating characteristic curves and the area under the curve were used to compare the accuracy of conventional MRI and cine MRI. RESULTS: Of the 15 patients, 8 (53.3%) had undergone IVC resection. We found that the absence of both dynamic blood flow and tumor thrombus mobility on cine MRI could reliably predict for IVC resection with 100% (95% confidence interval, 51.8%-100%) sensitivity and 85.7% (95% confidence interval, 42.1%-1.00%) specificity. The area under the receiver operating characteristic curve was 0.821 for conventional MRI and 0.929 for cine MRI. CONCLUSIONS: In the preoperative setting, cine MRI could be a helpful examination modality to predict for the need for IVC wall resection for patients with renal cell carcinoma with venous tumor thrombus.2022年07月, Journal of vascular surgery. Venous and lymphatic disorders, 10(4) (4), 908 - 915, 英語, 国際誌研究論文（学術雑誌）
- Viral hepatitis was previously the most common cause of chronic liver disease. However, in recent years, nonalcoholic fatty liver disease (NAFLD) cases have been increasing, especially in developed countries. NAFLD is histologically characterized by fat, fibrosis, and inflammation in the liver, eventually leading to cirrhosis and hepatocellular carcinoma. Although biopsy is the gold standard for the assessment of the liver parenchyma, quantitative evaluation methods, such as ultrasound, CT, and MRI, have been reported to have good diagnostic performances. The quantification of liver fat, fibrosis, and inflammation is expected to be clinically useful in terms of the prognosis, early intervention, and treatment response for the management of NAFLD. The aim of this review was to discuss the basics and prospects of MRI-based tissue quantifications of the liver, mainly focusing on proton density fat fraction for the quantification of fat deposition, MR elastography for the quantification of fibrosis, and multifrequency MR elastography for the evaluation of inflammation.2022年05月, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 英語, 国内誌研究論文（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2022年05月, 日本インターベンショナルラジオロジー学会雑誌, 37(Suppl.) (Suppl.), 238 - 238, 英語ラット肝細胞癌モデルにおける塞栓によるマクロファージの極性転換はレンバチニブによってリプログラムされ得る(Embolization Induced Macrophage Polarization can be Reprogrammed by Lenvatinib in Rat Hepatoma Model)
- Background: Prostate apparent diffusion coefficient (ADC) values calculated from diffusion-weighted imaging have been used for evaluating prostate cancer (PCa) aggressiveness. However, the way of measuring ADC values has varied depending on the study. Purpose: To investigate inter- and intra-reader variability and diagnostic performance of three kinds of shaped 2D regions of interests (ROIs) for tumor ADC measurements in PCa. Material and Methods: Seventy-four patients with PCa undergoing 3-T MRI before surgery were included. Histologic findings from radical prostatectomy specimens were reviewed to define each patient's dominant tumor. Three readers independently measured the tumor ADCs using three different ROI methods: freehand, large-circle, and small-circles ROIs. Readers repeated measurements after 3 weeks. Bland-Altman analysis was performed to evaluate the inter- and intra-reader variability. Receiver Operating Characteristic analysis was used for assessment of tumor aggressiveness for PCa. Results: For intra-reader and inter-reader variability, the mean coefficient of repeatability for freehand ROIs, large-circle ROIs, and small-circles ROIs were as follows: 13.7%, 12.4%, and 11.5%; 9.4%, 9.7%, and 9.5%. For differentiating Gleason score (GS) = 3 + 3 from GS ≥ 3 + 4 tumors, the area under the curves were 0.90 for freehand ROIs, 0.89 for large-circle ROIs, and 0.94 small-circles ROIs (p = 0.31). Conclusion: The variations in ROI method did not have a major influence on intra-reader or inter-reader reproducibility or diagnostic performance for prostate ADC measurements.2022年03月, Acta radiologica open, 11(3) (3), 20584601221086500 - 20584601221086500, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: To investigate the diagnostic performance of the extracellular volume (ECV) fraction in multiphasic contrast-enhanced computed tomography (CE-CT) for estimating histologic pancreatic fibrosis and predicting postoperative pancreatic fistula (POPF). METHODS: Eighty-five patients (49 men; mean age, 69 years) who underwent multiphasic CE-CT followed by pancreaticoduodenectomy with pancreaticojejunal anastomosis between January 2012 and December 2018 were retrospectively included. The ECV fraction was calculated from absolute enhancements of the pancreas and aorta between the precontrast and equilibrium-phase images, followed by comparisons among histologic pancreatic fibrosis grades (F0‒F3). The diagnostic performance of the ECV fraction in advanced fibrosis (F2‒F3) was evaluated using receiver operating characteristic curve analysis. Multivariate logistic regression analysis was used to evaluate the associations of the risk of POPF development with patient characteristics, histologic findings, and CT imaging parameters. RESULTS: The mean ECV fraction of the pancreas was 34.4% ± 9.5, with an excellent intrareader agreement of 0.811 and a moderate positive correlation with pancreatic fibrosis (r = 0.476; p < 0.001). The mean ECV fraction in advanced fibrosis was significantly higher than that in no/mild fibrosis (44.4% ± 10.8 vs. 31.7% ± 6.7; p < 0.001), and the area under the receiver operating characteristic curve for the diagnosis of advanced fibrosis was 0.837. Twenty-two patients (25.9%) developed clinically relevant POPF. Multivariate logistic regression analysis demonstrated that the ECV fraction was a significant predictor of POPF. CONCLUSIONS: The ECV fraction can offer quantitative information for assessing pancreatic fibrosis and POPF after pancreaticojejunal anastomosis. KEY POINTS: • There was a moderate positive correlation of the extracellular volume (ECV) fraction of the pancreas in contrast-enhanced CT with the histologic grade of pancreatic fibrosis (r = 0.476; p < 0.001). • The ECV fraction was higher in advanced fibrosis (F2‒F3) than in no/mild fibrosis (F0‒F1) (p < 0.001), with an AUC of 0.837 for detecting advanced fibrosis. • The ECV fraction was an independent risk factor for predicting subclinical (odds ratio, 0.81) and clinical (odds ratio, 0.80) postoperative pancreatic fistula.2022年03月, European radiology, 32(3) (3), 1770 - 1780, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: The purpose is to investigate the major and minor complications of the pancreas after transcatheter arterial embolization (TAE) using n-butyl-2-cyanoacrylate (NBCA) for bleeding from pancreatic arteries. MATERIALS AND METHODS: Thirty-three patients who underwent TAE using NBCA for acute bleeding from pancreatic arteries and their parent arteries followed by contrast-enhanced computed tomography (CE-CT) were evaluated retrospectively. Complications and risk factors were assessed using Mann-Whitney U test or Fisher's exact test for the univariate analysis. Patients' characteristic, embolized artery, procedure details, and clinical outcomes were examined as possible risk factors. RESULTS: TAE was performed successfully in all patients. Minor pancreatic complications occurred in 10 patients (30%), including acute mild pancreatitis (n = 4) and focal lack of pancreatic parenchymal enhancement on CE-CT without pancreatitis (n = 6). No cases of major pancreatic complications, such as moderate/severe pancreatitis, were reported. Embolized artery was the only significant risk factor. The rate of complications per embolized artery were 15% (three out of 20 patients) in the arteries of the pancreatic head and 54% (seven out of 13 patients) in the arteries of pancreatic body and tail (p = 0.025). CONCLUSION: TAE using NBCA for acute bleeding from pancreatic arteries is efficacious and safe. Mild pancreatic complications were observed more frequently in case of embolization of the pancreatic body and tail region than the pancreatic head.2022年03月, Japanese journal of radiology, 40(3) (3), 308 - 317, 英語, 国内誌研究論文（学術雑誌）
- For assessing a cancer treatment, and for detecting and characterizing cancer, Diffusion-weighted imaging (DWI) is commonly used. The key in DWI's use extracranially has been due to the emergence of of high-gradient amplitude and multichannel coils, parallelimaging, and echo-planar imaging. The benefit has been fewer motion artefacts and high-quality prostate images.Recently, new techniques have been developed to improve the signal-to-noise ratio of DWI with fewer artefacts, allowing an increase in spatial resolution. For apparent diffusion coefficient quantification, non-Gaussian diffusion models have been proposed as additional tools for prostate cancer detection and evaluation of its aggressiveness. More recently, radiomics and machine learning for prostate magnetic resonance imaging have emerged as novel techniques for the non-invasive characterisation of prostate cancer. This review presents recent developments in prostate DWI and discusses its potential use in clinical practice.2022年03月, The British journal of radiology, 95(1131) (1131), 20210653 - 20210653, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: To evaluate the interreader agreement and diagnostic performance of the Prostate Imaging Reporting and Data System (PI-RADS) v. 2.1, in comparison with v. 2. METHODS: Institutional review board approval was obtained for this retrospective study. 77 consecutive patients who underwent a prostate multiparametric magnetic resonance imaging at 3.0 T before radical prostatectomy were included. Four radiologists (two experienced uroradiologists and two inexperienced radiologists) independently scored eight regions [six peripheral zones (PZ) and two transition zones (TZ)] using v. 2.1 and v. 2. Interreader agreement was assessed using κ statistics. To evaluate diagnostic performance for clinically significant prostate cancer (csPC), area under the curve (AUC) was estimated. RESULTS: 228 regions were pathologically diagnosed as positive for csPC. With a cut-off ≥3, the agreement among all readers was better with v. 2.1 than v. 2 in TZ, PZ, or both zones combined (κ-value: TZ, 0.509 vs 0.414; PZ, 0.686 vs 0.568; both zones combined, 0.644 vs 0.531). With a cut-off ≥4, the agreement among all readers was also better with v. 2.1 than v. 2 in the PZ or both zones combined (κ-value: PZ, 0.761 vs 0.701; both zones combined, 0.756 vs 0.709). For all readers, AUC with v. 2.1 was higher than with v. 2 (TZ, 0.826-0.907 vs 0.788-0.856; PZ, 0.857-0.919 vs 0.853-0.902). CONCLUSION: Our study suggests that the PI-RADS v. 2.1 could improve the interreader agreement and might contribute to improved diagnostic performance compared with v. 2. ADVANCES IN KNOWLEDGE: PI-RADS v. 2.1 has a potential to improve interreader variability and diagnostic performance among radiologists with different levels of expertise.2022年03月, The British journal of radiology, 95(1131) (1131), 20201434 - 20201434, 英語, 国際誌研究論文（学術雑誌）
- Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA; Gadoxetic acid; Gadoxetate disodium) is a hepatocyte-specific MR contrast agent. It acts as an extracellular contrast agent in the early phase after intravenous injection, and then is taken up by hepatocytes later. Using this contrast agent, we can evaluate the hemodynamics of the liver and liver tumors, and can therefore improve the detection and characterization of hepatocellular carcinoma (HCC). Gd-EOB-DTPA helps in the more accurate detection of hypervascular HCC than by other agents. In addition, Gd-EOB-DTPA can detect hypovascular HCC, which is an early stage of the multi-stage carcinogenesis, with a low signal in the hepatobiliary phase. In addition to tumor detection and characterization, Gd-EOB-DTPA contrast-enhanced MR imaging can be applied for liver function evaluation and prognoses evaluation. Thus, Gd-EOB-DTPA plays an important role in the diagnosis of HCC. However, we have to employ optimal imaging techniques to improve the diagnostic ability. In this review, we aimed to discuss the characteristics of the contrast media, optimal imaging techniques, diagnosis, and applications.2022年03月, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 21(1) (1), 168 - 181, 英語, 国内誌研究論文（学術雑誌）
- (公社)日本医学放射線学会, 2022年02月, Japanese Journal of Radiology, 40(Suppl.) (Suppl.), 39 - 39, 日本語123I-MIBGシンチグラフィで腎に異常集積を認めた腎動脈解離の1例
- OBJECTIVE: The purpose of this study was to investigate outcomes of transarterial chemoembolization (TACE) in treating hepatocellular carcinoma (HCC) comparing the different approaches used in Germany and Japan. METHODS: This binational IRB-approved retrospective dual-center study included a total of 94 HCC patients subdivided in a German and a Japanese cohort. For each patient, liver and tumor volumetry was performed using computed tomography (CT) and magnetic resonance imaging (MRI). Furthermore, a comprehensive risk profile, including body constitution and liver and kidney function was established. Primary endpoints were progression-free and overall survival (PFS/OS). RESULTS: PFS in the German cohort was 168 vs 224d in the Japanese cohort (p=0.640). When subdivided by BCLC stage, no significant differences were reported (p=0.160-0.429). OS was significantly longer in the Japanese cohort with 856 vs. 303d (p<0.001). OS for BCLC A was significantly longer in the Japanese cohort (1960 vs. 428d; p<0.001), while survival rates did not differ significantly in BCLC B (785 vs 330d; p=0.067) and C-stages (208 vs 302d; p=0.186). Older age (p=0.034), poorer liver/kidney function (p=0.025-0-035), and a higher liver/tumor ratio (p<0.001) were found to correlate with shorter survival. ECOG scores were significantly higher in the German cohort (p=0.002). CONCLUSION: While OS is longer in TACE-treated patients in the Japanese cohort compared to the German cohort, the two approaches seem to be equally effective as PFS does not differ significantly. The different survival rates may be caused by the different clinical performance status of the selected collectives. In very early and early stage HCC, TACE in Japan seems to be an effective treatment option while in Germany for patients in those stages TACE remains a second-line option for patients not available for surgery or ablation.Informa UK Limited, 2022年08月, Journal of hepatocellular carcinoma, 9, 695 - 705, 英語, 国際誌研究論文（学術雑誌）
- 産業開発機構(株), 2021年12月, 映像情報Medical, 53(14) (14), 106 - 113, 日本語
- PURPOSE: To evaluate the efficacy of superselective transcatheter arterial embolization (TAE) for intractable postpartum hemorrhage (PPH) due to genital tract trauma (GTT) after vaginal delivery. METHODS: We evaluated 27 patients who underwent TAE for intractable PPH due to GTT after vaginal delivery at our institution between January 2008 and December 2020. Patients were divided into two groups according to TAE procedure; TAE performed as close as possible to the bleeding point, at least more peripherally than the second branch of the anterior division of the internal iliac artery, was defined as superselective TAE (S-TAE). TAE performed from the proximal segment of the internal iliac artery was defined as proximal TAE (P-TAE). Patient characteristics, pre-procedural contrast-enhanced computed tomography (CE-CT), procedure details, technical/clinical success, and complications were evaluated separately for the S-TAE and P-TAE groups. RESULTS: The combined technical/clinical success rate was 92%. No major procedure-related complications were seen (mean follow-up: 6.12 ± 3.93 days). The combined technical/clinical success rate of S-TAE was 100% and of P-TAE was 67% (p = 0.04). S-TAE was performed more frequently in patients with pre-procedural CE-CT (p = 0.01) and use of permanent embolic materials (p = 0.003). CONCLUSION: S-TAE is safe and effective for intractable PPH due to GTT. Pre-procedural CE-CT may be useful for detecting the culprit artery and be helpful in performing S-TAE.2021年12月, Emergency radiology, 28(6) (6), 1127 - 1133, 英語, 国際誌研究論文（学術雑誌）
- (一社)西日本泌尿器科学会, 2021年11月, 西日本泌尿器科学会総会抄録集, 73回, 166 - 166, 英語術前cine MRIによる腎癌血栓の下大静脈壁への癒着評価の有効性(The efficacy of pre-operative cine MRI to evaluate the adhesion of renal cancer thrombus to the wall of inferior vena cava)
- (一社)西日本泌尿器科学会, 2021年11月, 西日本泌尿器科学会総会抄録集, 73回, 166 - 166, 英語The efficacy of pre-operative cine MRI to evaluate the adhesion of renal cancer thrombus to the wall of inferior vena cava(和訳中)
- INTRODUCTION: Immune checkpoint inhibitors (ICIs) are promising agents for the treatment of hepatocellular carcinoma (HCC). However, the establishment of noninvasive measure that could predict the response to ICIs is challenging. This study aimed to evaluate tumor responses to ICIs using the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI), which was shown to reflect Wnt/β-catenin activating mutation. METHODS: A total of 68 intrahepatic HCC nodules from 18 patients with unresectable HCC and Child-Pugh class A liver function who received anti-programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) monotherapy were enrolled in this study. All patients had viable intrahepatic lesions evaluable using the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI within the 6 months prior to the treatment. The relative enhancement ratio was calculated, and the time to nodular progression (TTnP) defined as 20% or more increase in each nodule was compared between higher or hypo-enhancement HCC nodules. Then, the progression-free survival (PFS) and objective response rate (ORR) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) were compared between patients with and without HCC nodules with higher enhancement on hepatobiliary phase images. RESULTS: The median PFS was 2.7 (95% confidence interval [CI]: 1.4-4.0) months in patients with HCC nodules with higher enhancement (n = 8) and 5.8 (95% CI: 0.0-18.9) months in patients with hypointense HCC nodules (n = 10) (p = 0.007). The median TTnP of HCC nodules with higher enhancement (n = 23) was 1.97 (95% CI: 1.86-2.07) months and that of hypointense HCC nodules (n = 45) was not reached (p = 0.003). The ORR was 12.5% (1/8) versus 30.0% (3/10); the disease control rate was 37.5% (3/8) versus 70.0% (7/10), respectively, in patients with or without higher enhancement intrahepatic HCC nodules. CONCLUSION: The TTnP on HCC nodules with higher enhancement and the median PFS in patients who carried higher enhancement intrahepatic HCC nodules were significantly shorter than those in hypointense HCC nodules with anti-PD-1/PD-L1 monotherapy. The intensity of the nodule on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI is a promising imaging biomarker for predicting unfavorable response with anti-PD-1/PD-L1 monotherapy in patients with HCC.2021年11月, Liver cancer, 10(6) (6), 615 - 628, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: Sarcopenia has been reported to be a significant prognostic factor in patients with hepatocellular carcinoma in recent years. This study aimed to clarify the prognostic significance of sarcopenia in advanced hepatocellular carcinoma treated with reductive hepatectomy. PATIENTS AND METHODS: We retrospectively analyzed 93 patients who underwent reductive hepatectomy for advanced hepatocellular carcinoma. RESULTS: Median survival time of the sarcopenia group (16.4 months) was significantly shorter than that of the non-sarcopenia group (20.4 months). The overall survival rates at 1, 3, and 5 years of the sarcopenia group were significantly lower than those of the non-sarcopenia group (57.9%, 8.6%, and 2.9% vs. 67.3%, 29.2%, and 15.7%, respectively; p=0.035). On multivariate analysis, sarcopenia was a significant risk factor of overall survival (hazard ratio=1.60, 95% confidence interval=1.00-2.56, p=0.049). CONCLUSION: Sarcopenia was a significant prognostic factor of survival after reductive hepatectomy in advanced hepatocellular carcinoma.2021年11月, Anticancer research, 41(11) (11), 5775 - 5783, 英語, 国際誌研究論文（学術雑誌）
- (公社)日本医学放射線学会, 2021年08月, 日本医学放射線学会秋季臨床大会抄録集, 57回, S464 - S464, 日本語逆チャンス型胸椎骨折による血胸の一例
- (株)アークメディア, 2021年08月, 肝胆膵, 83(2) (2), 209 - 218, 日本語【ここまできた肝細胞癌の薬物療法:2021 update】免疫療法の動向 WNT/β-catenin変異のimaging biomarkerとしてのEOB-MRI
- Background: Technological developments have led to an increased usage of external-body radiotherapy (RT) for the treatment of hepatocellular carcinoma (HCC). Transcatheter arterial chemoembolization (TACE) may be required later in patients treated with RT because of the high recurrence rate and multinodular presentation of HCC. However, despite the risk of liver function impairment, the cumulative liver damage correlated with TACE following a hepatic RT has not been adequately assessed. Purpose: To evaluate the feasibility of TACE following RT for HCC. Materials and methods: Sixty-seven patients with HCC who underwent TACE after RT were retrospectively evaluated between 2012 and 2018. We assessed increases in Child-Turcotte-Pugh (CTP) by ≥2 points at 1 month, the incidence of major complications, survival duration, and short-term mortality within 6 months after TACE. Furthermore, we evaluated the predictive factors for liver function impairment and short-term mortality. Results: Eight patients experienced a CTP increase ≥2 points at 1 month. There were no cases of liver abscesses or bilomas. Nine patients died within 6 months following TACE. The mean liver dose (MLD) was a significant predictor of liver function impairment at 1 month (p = 0.042). Low liver functional reserve, distant metastasis (p = 0.037), MLD (p = 0.046), TACE type (p = 0.025), and TACE within 3 months following RT (p = 0.007) were significant predictors of short-term mortality. Conclusions: Despite the feasibility of TACE following RT, clinicians should pay attention to impaired pretreatment liver function, following high dose RT, and the short duration between RT and TACE.2021年07月, Acta radiologica open, 10(7) (7), 20584601211034965 - 20584601211034965, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVES: To evaluate a deep learning model for predicting gestational age from fetal brain MRI acquired after the first trimester in comparison to biparietal diameter (BPD). MATERIALS AND METHODS: Our Institutional Review Board approved this retrospective study, and a total of 184 T2-weighted MRI acquisitions from 184 fetuses (mean gestational age: 29.4 weeks) who underwent MRI between January 2014 and June 2019 were included. The reference standard gestational age was based on the last menstruation and ultrasonography measurements in the first trimester. The deep learning model was trained with T2-weighted images from 126 training cases and 29 validation cases. The remaining 29 cases were used as test data, with fetal age estimated by both the model and BPD measurement. The relationship between the estimated gestational age and the reference standard was evaluated with Lin's concordance correlation coefficient (ρc) and a Bland-Altman plot. The ρc was assessed with McBride's definition. RESULTS: The ρc of the model prediction was substantial (ρc = 0.964), but the ρc of the BPD prediction was moderate (ρc = 0.920). Both the model and BPD predictions had greater differences from the reference standard at increasing gestational age. However, the upper limit of the model's prediction (2.45 weeks) was significantly shorter than that of BPD (5.62 weeks). CONCLUSIONS: Deep learning can accurately predict gestational age from fetal brain MR acquired after the first trimester. KEY POINTS: • The prediction of gestational age using ultrasound is accurate in the first trimester but becomes inaccurate as gestational age increases. • Deep learning can accurately predict gestational age from fetal brain MRI acquired in the second and third trimester. • Prediction of gestational age by deep learning may have benefits for prenatal care in pregnancies that are underserved during the first trimester.2021年06月, European radiology, 31(6) (6), 3775 - 3782, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2021年04月, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 160 - 160, 日本語Shaggy aorta症例における上腸間膜動脈バルーンプロテクション併用下TEVARの有用性の検討
- (一社)日本インターベンショナルラジオロジー学会, 2021年04月, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 201 - 201, 英語上顎癌動注化学療法における腫瘍進展方向と栄養血管に関する検討(Tumor extension and feeding arteries in intraarterial chemotherapy for maxillary cancer)
- (一社)日本インターベンショナルラジオロジー学会, 2021年04月, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 251 - 251, 日本語陰部腟静脈瘤に対し血管内治療を行った1例
- 2021年04月, Japanese journal of radiology, 39(4) (4), 405 - 405, 英語, 国内誌
- BACKGROUND. The Vesical Imaging Reporting and Data System (VI-RADS), based on multiparametric MRI (mpMRI), was developed to provide accurate information for the diagnosis of muscle-invasive bladder cancer (MIBC). OBJECTIVE. The purpose of our study was to evaluate the interobserver agreement and diagnostic performance of VI-RADS among readers with different levels of experience. METHODS. This retrospective study included 91 consecutive patients who underwent mpMRI before transurethral resection of bladder tumor (TURBT) from July 2010 through August 2018. After attending a training session, seven radiologists (five radiologists experienced in bladder MRI and two inexperienced radiologists) reviewed and scored all MRI examinations according to VI-RADS. The interobserver agreement was assessed by kappa statistics. ROC analysis was used to evaluate the diagnostic performance for MIBC. AUCs were estimated. RESULTS. Among 91 patients (72 men and 19 women; mean age ± SD, 73.2 ± 10.2 years), 48 (52.7%) had MIBC and 43 (47.3%) had non-muscle-invasive bladder cancer. Sixty-eight patients were treated with TURBT, and 23 were treated with radical cystectomy. Interobserver agreement was moderate to substantial (κ = 0.60-0.80) among the experienced readers, substantial (κ = 0.67) between the two inexperienced readers, and moderate to substantial (κ = 0.55-0.75) between the experienced and inexperienced readers. The pooled AUC was 0.88 (range, 0.82-0.91) for experienced readers and 0.84 (range, 0.83-0.85) for inexperienced readers, and 0.87 for all readers. Using a VI-RADS score of 4 or greater as the cutoff value for MIBC, the pooled sensitivity and specificity were 74.1% (range, 66.0-80.9%) and 94.1% (range, 88.6-97.7%) for experienced readers and 63.9% (range, 59.6-68.1%) and 86.4% (range, 84.1-88.6%) for inexperienced readers. Using a VI-RADS score of 3 or greater as the cutoff value, the pooled sensitivity and specificity were 83.4% (range, 80.9-85.1%) and 77.3% (range, 61.4-88.6%) for experienced readers and 82.0% (range, 80.9-83.0%) and 73.9% (range, 72.7-75.0%) for inexperienced readers. CONCLUSION. We observed moderate to substantial interobserver agreement and a pooled AUC of 0.87 among radiologists of different levels of expertise using VI-RADS. CLINICAL IMPACT. VI-RADS could help determine the depth and range of excision in TURBT, decreasing the risk of complications and enhancing the accuracy of pathologic diagnosis.2021年03月, AJR. American journal of roentgenology, 216(5) (5), 1 - 10, 英語, 国際誌研究論文（学術雑誌）
- Carbon dioxide (CO2) treatment is reported to have an antitumor effect owing to the improvement in intratumoral hypoxia. Previous studies were based on histological analysis alone. In the present study, the improvement in intratumoral hypoxia by percutaneous CO2 treatment in vivo was determined using 18F-fluoromisonidazole positron emission tomography-computed tomography (18F-FMISO PET-CT) images. Twelve Japanese nude mice underwent implantation of LM8 tumor cells in the dorsal subcutaneous area 2 weeks before percutaneous CO2 treatment and 18F-FMISO PET-CT scans. Immediately after intravenous injection of 18F-FMISO, CO2 and room air were administered transcutaneously in the CO2-treated group (n=6) and a control group (n=6), respectively; each treatment was performed for 10 minutes. PET-CT was performed 2 h after administration of 18F-FMISO. 18F-FMISO tumor uptake was quantitatively evaluated using the maximum standardized uptake value (SUVmax), tumor-to-liver ratio (TLR), tumor-to-muscle ratio (TMR), metabolic tumor volume (MTV) and total lesion glycolysis (TLG). Mean ± standard error of the mean (SEM) of the tumor volume was not significantly different between the two groups (CO2-treated group, 1.178±0.450 cm3; control group, 1.368±0.295 cm3; P=0.485). Mean ± SEM of SUVmax, TLR, MTV (cm3) and TLG were significantly lower in the CO2-treated group compared with the control group (0.880±0.095 vs. 1.253±0.071, P=0.015; 1.063±0.147361 vs. 1.455±0.078, P=0.041; 0.353±0.139 vs. 1.569±0.438, P=0.015; 0.182±0.070 vs. 1.028±0.338, P=0.015), respectively. TMR was not significantly different between the two groups (4.520±0.503 vs. 5.504±0.310; P=0.240). In conclusion, 18F-FMISO PET revealed that percutaneous CO2 treatment improved intratumoral hypoxia in vivo. This technique enables assessment of the therapeutic effect in CO2 treatment by imaging, and may contribute to its clinical application.2021年03月, Oncology letters, 21(3) (3), 207 - 207, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: To identify predictive factors for truncation artifacts (TAs) in the arterial phase of Gd-EOB-DTPA-enhanced MRI in a multicenter study in Japan. MATERIALS AND METHODS: Data on patient factors (age, sex, weight, presence of viral hepatitis, and other conditions) and imaging parameters (e.g., triggering, voxel size, matrix, k-space ordering, acquisition time, reduction factor, flip angle, fat suppression, field strength, injection rate, and saline volume) were obtained. Univariate and multivariate analyses were performed to investigate the correlation of these parameters. RESULTS: We evaluated 1444 patients from 43 institutions who were scanned using GE, Siemens, Philips, or Toshiba MRI equipment (501, 354, 349, and 240 patients, respectively). The total incidence of TAs was 12.5% (17.2, 3.6, 15.7, and 12.1%, respectively). The matrix [odds ratio (OR) 0.13], flip angle (OR 5.77), use of fat suppression (OR 0.106), and field strength (OR 0.092) used in the Philips equipment significantly increased the incidence of TAs in MRI examination. CONCLUSIONS: The incidence of TAs in the arterial phase is influenced by several patient factors and imaging parameters. Especially, Siemens and Toshiba equipment had a significantly lower frequency of TAs. This indicates that such vendor-specific technology used in the dynamic sequence may have a TA-resistant effect.2021年02月, Japanese journal of radiology, 39(2) (2), 165 - 177, 英語, 国内誌研究論文（学術雑誌）
- Dual-energy computed tomography (DECT) is an imaging technique based on data acquisition at two different energy settings. Recent advances in CT have allowed data acquisitions and simultaneous analyses of X-rays at two energy levels, and have resulted in novel developments in the field of abdominal imaging. The use of low and high X-ray tube voltages in DECT provide fused images that improve the detection of liver tumors owing to the higher contrast-to-noise ratio (CNR) of the tumor compared with the liver. The use of contrast agents in CT scanning improves image quality by enhancing the CNR and signal-to-noise ratio while reducing beam-hardening artifacts. DECT can improve detection and characterization of hepatic abnormalities, including mass lesions. The technique can also be used for the diagnosis of steatosis and iron overload. This article reviews and illustrates the different applications of DECT in liver imaging.2021年01月, Diagnostics (Basel, Switzerland), 11(2) (2), 英語, 国際誌研究論文（学術雑誌）
- (一社)日本血管内治療学会, 2021年, 日本血管内治療学会誌, 22(1) (1), 50 - 53, 日本語【血管内治療における抗血栓療法】外傷性・医原性血管損傷に対するバイアバーン留置後の抗血栓療法
- (一社)日本血管内治療学会, 2021年, 日本血管内治療学会誌, 22(1) (1), 50 - 53, 日本語【血管内治療における抗血栓療法】外傷性・医原性血管損傷に対するバイアバーン留置後の抗血栓療法
- BACKGROUND: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is associated with acute pancreatitis (AP) in some cases, however its causes have not been fully elucidated. We investigated the association of the incidence of AP with epithelial subtypes and pancreatic volume in IPMN. METHODS: This retrospective study included 182 consecutive surgically resected IPMN patients between January 2000 and December 2018. The relationship between the incidence of AP and epithelial subtypes of IPMN and pancreatic volume was investigated. Epithelial subtypes of IPMN were classified into gastric (G type: N = 116), intestinal (I type: N = 49), pancreatobiliary (PB type: N = 14), and oncocytic types (O type: N = 3). Pancreatic volume of the contrast-enhanced computed tomography scan was measured using Ziostation2 software. Histological pancreatic parenchymal atrophy was also evaluated. RESULTS: AP occurred more frequently in I-types (I-type vs. G-type, 22.4% [11/49] vs 3.4% [4/116], P = 0.003) and PB-types (PB type vs. G-type, 35.7% [5/14] vs. 3.4% [4/116], P = 0.007) in comparison with G-types, which constituted the majority of the resected IPMNs. AP occurred more frequently in I-type patients with high pancreatic volumes (I-type with high pancreatic volume vs. I-type with low pancreatic volume, 37.0% [10/27] vs. 4.7% [1/21], P = 0.02). However, histological atrophy did not show an additional influence on the association between the incidence of AP and epithelial subtypes. The elevation of serum pancreatic enzymes was not significantly related to epithelial subtypes. CONCLUSION: Epithelial subtypes and the degree of pancreatic volume may be closely associated with the incidence of AP in IPMN.2021年01月, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 21(1) (1), 138 - 143, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: To retrospectively assess the repeatability of physiological F-18 labeled fluorodeoxyglucose (FDG) uptake in the skin on positron emission tomography/magnetic resonance imaging (PET/MRI) and explore its regional distribution and relationship with sex and age. METHODS: Out of 562 examinations with normal FDG distribution on whole-body PET/MRI, 74 repeated examinations were evaluated to assess the repeatability and regional distribution of physiological skin uptake. Furthermore, 224 examinations were evaluated to compare differences in the uptake due to sex and age. Skin segmentation on PET was performed as body-surface contouring on an MR-based attenuation correction map using an off-line reconstruction software. Bland-Altman plots were created for the repeatability assessment. Kruskal-Wallis test was performed to compare the maximum standardized uptake value (SUVmax) with regional distribution, age, and sex. RESULTS: The limits of agreement for the difference in SUVmean and SUVmax of the skin were less than 30%. The highest SUVmax was observed in the face (3.09±1.04), followed by the scalp (2.07±0.53). The SUVmax in the face of boys aged 0-9 years and 10-20 years (1.33±0.64 and 2.05±1.00, respectively) and girls aged 0-9 years (0.98±0.38) was significantly lower than that of men aged ≥20 years and girls aged ≥10 years (p<0.001). In women, the SUVmax of the face (2.31±0.71) of ≥70-year-olds was significantly lower than that of 30-39-year-olds (3.83±0.82) (p<0.05). CONCLUSION: PET/MRI enabled the quantitative analysis of skin FDG uptake with repeatability. The degree of physiological FDG uptake in the skin was the highest in the face and varied between sexes. Although attention to differences in body habitus between age groups is needed, skin FDG uptake also depended on age.2021年, PloS one, 16(3) (3), e0249304, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Postoperative biliary strictures are commonly related to accidental bile duct injuries or occur at the site of biliary anastomosis. The first-line treatment for benign biliary strictures is endoscopic therapy, which is less invasive and repeatable. However, recanalization for biliary complete obstruction is technically challenging to treat. The present report describes a successful case of treatment by extraluminal recanalization for postoperative biliary obstruction using a transseptal needle. CASE PRESENTATION: A 66-year-old woman had undergone caudal lobectomy for the treatment of hepatocellular carcinoma. The posterior segmental branch of the bile duct was injured and repaired intraoperatively. Three months after the surgery, the patient had developed biliary leakage from the right hepatic bile duct, resulting in complete biliary obstruction. Since intraluminal recanalization with conventional endoscopic and percutaneous approaches with a guidewire failed, extraluminal recanalization using a transseptal needle with an internal lumen via percutaneous approach was performed under fluoroscopic guidance. The left lateral inferior segmental duct was punctured, and an 8-F transseptal sheath was introduced into the ostium of right hepatic duct. A transseptal needle was advanced, and the right hepatic duct was punctured by targeting an inflated balloon that was placed at the end of the obstructed right hepatic bile duct. After confirming successful puncture using contrast agent injected through the internal lumen of the needle, a 0.014-in. guidewire was advanced into the right hepatic duct. Finally, an 8.5-F internal-external biliary drainage tube was successfully placed without complications. One month after the procedure, the drainage tube was replaced with a 10.2-F drainage tube to dilate the created tract. Subsequent endoscopic internalization was performed 5 months after the procedure. At the 1-year follow-up examination, there was no sign of biliary obstruction and recurrence of hepatocellular carcinoma. CONCLUSIONS: Recanalization using a transseptal needle can be an alternative technique for rigid biliary obstruction when conventional techniques fail.2020年12月, Surgical case reports, 6(1) (1), 304 - 304, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Hierarchical clustering (HC), an unsupervised machine learning (ML) technique, was applied to multi-parametric MR (mp-MR) for prostate cancer (PCa). The aim of this study is to demonstrate HC can diagnose PCa in a straightforward interpretable way, in contrast to deep learning (DL) techniques. METHODS: HC was constructed using mp-MR including intravoxel incoherent motion, diffusion kurtosis imaging, and dynamic contrast-enhanced MRI from 40 tumor and normal tissues in peripheral zone (PZ) and 23 tumor and normal tissues in transition zone (TZ). HC model was optimized by assessing the combinations of several dissimilarity and linkage methods. Goodness of HC model was validated by internal methods. RESULTS: Accuracy for differentiating tumor and normal tissue by optimal HC model was 96.3% in PZ and 97.8% in TZ, comparable to current clinical standards. Relationship between input (DWI and permeability parameters) and output (tumor and normal tissue cluster) was shown by heat maps, consistent with literature. CONCLUSION: HC can accurately differentiate PCa and normal tissue, comparable to state-of-the-art diffusion based parameters. Contrary to DL techniques, HC is an operator-independent ML technique producing results that can be interpreted such that the results can be knowledgeably judged.2020年12月, Magnetic resonance imaging, 74, 90 - 95, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本核医学会, 2020年10月, 核医学, 57(Suppl.) (Suppl.), S155 - S155, 英語肺病変に関するPET/MRIにおけるZero-TE法の診断能について
- (一社)日本核医学会, 2020年10月, 核医学, 57(Suppl.) (Suppl.), S174 - S174, 日本語悪性腫瘍の全身FDG PET/MRIにおけるBSREMを用いた高速撮像と診断能の検討
- (一社)日本核医学会, 2020年10月, 核医学, 57(Suppl.) (Suppl.), S155 - S155, 英語肺病変に関するPET/MRIにおけるZero-TE法の診断能について
- (一社)日本核医学会, 2020年10月, 核医学, 57(Suppl.) (Suppl.), S174 - S174, 日本語悪性腫瘍の全身FDG PET/MRIにおけるBSREMを用いた高速撮像と診断能の検討
- (公社)日本医学放射線学会, 2020年10月, 日本医学放射線学会秋季臨床大会抄録集, 56回, S144 - S144, 日本語治療適応の基準を満たさない腎血管筋脂肪腫の破裂
- PURPOSE: Accurate prediction of post-hepatectomy liver failure (PHLF) is important in advanced hepatocellular carcinoma (HCC). We aimed to retrospectively evaluate the utility of gadoxetic acid-enhanced MRI for predicting PHLF in patients who underwent anatomic hepatectomy for HCC with portal vein invasion. METHODS: Forty-one patients (32 men, 9 women) were included. Hepatobiliary-phase MR images were acquired 20 min after injection of gadoxetic acid using a 3D fat-suppressed T1-weighted spoiled gradient-echo sequence. Liver-spleen ratio (LSR), remnant hepatocellular uptake index (rHUI), and HUI were calculated. The severity of PHLF was defined according to the International Study Group of Liver Surgery. Differences in LSR between the resected liver and the remnant liver, and HUI and rHUI/HUI between no/mild and severe PHLF were compared using the Wilcoxon signed-rank test and Wilcoxon rank-sum test, respectively. Univariate and multivariate logistic regression analyses were performed to identify predictors of severe PHLF. Areas under the receiver operating characteristic curves (AUCs) of rHUI and rHUI/HUI were calculated for predicting severe PHLF. RESULTS: Nine patients developed severe PHLF. LSR of the remnant liver was significantly higher than that of the resected liver (P < 0.001). Severe PHLF demonstrated significantly lower rHUI (P < 0.001) and rHUI/HUI (P < 0.001) compared with no/mild PHLF. Multivariate logistic regression analysis showed that decreased rHUI (P = 0.012, AUC=0.885) and rHUI/HUI (P = 0.002, AUC=0.852) were independent predictors of severe PHLF. CONCLUSION: Gadoxetic acid-enhanced MRI can be a promising noninvasive examination for assessing global and regional liver function, allowing estimation of the functional liver remnant and accurate prediction of severe PHLF before hepatic resection.2020年09月, European journal of radiology, 130, 109189 - 109189, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2020年08月, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 122 - 122, 日本語液体塞栓物質(NBCA)を極める! エキスパートへの道 膵領域の急性出血に対するNBCAを用いた動脈塞栓術の検討
- (一社)日本インターベンショナルラジオロジー学会, 2020年08月, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 282 - 282, 日本語ドセタキセル含浸薬剤溶出性ビーズの基礎的検討
- 2020年08月, JGH open : an open access journal of gastroenterology and hepatology, 4(4) (4), 677 - 683, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- The usefulness of sparse-sampling CT with deep learning-based reconstruction for detection of metastasis of malignant ovarian tumors was evaluated. We obtained contrast-enhanced CT images (n = 141) of ovarian cancers from a public database, whose images were randomly divided into 71 training, 20 validation, and 50 test cases. Sparse-sampling CT images were calculated slice-by-slice by software simulation. Two deep-learning models for deep learning-based reconstruction were evaluated: Residual Encoder-Decoder Convolutional Neural Network (RED-CNN) and deeper U-net. For 50 test cases, we evaluated the peak signal-to-noise ratio (PSNR) and structural similarity (SSIM) as quantitative measures. Two radiologists independently performed a qualitative evaluation for the following points: entire CT image quality; visibility of the iliac artery; and visibility of peritoneal dissemination, liver metastasis, and lymph node metastasis. Wilcoxon signed-rank test and McNemar test were used to compare image quality and metastasis detectability between the two models, respectively. The mean PSNR and SSIM performed better with deeper U-net over RED-CNN. For all items of the visual evaluation, deeper U-net scored significantly better than RED-CNN. The metastasis detectability with deeper U-net was more than 95%. Sparse-sampling CT with deep learning-based reconstruction proved useful in detecting metastasis of malignant ovarian tumors and might contribute to reducing overall CT-radiation exposure.MDPI AG, 2020年06月, Applied Sciences, 10(13) (13), 4446 - 4446研究論文（学術雑誌）
- PURPOSE: To evaluate the mid-term outcomes of transarterial embolization (TAE) for type II endoleak after endovascular abdominal aortic aneurysm repair (EVAR) and investigate the predictors of sac enlargement after embolization. MATERIALS AND METHODS: We conducted a retrospective analysis of 55 patients [48 men and 7 women, median age 79.0 (interquartile ranges 74-82) years] who underwent TAE for type II endoleak from 2010 to 2018. The aneurysmal sac enlargement, endoleaks, aneurysm-related adverse event rate, and reintervention rate were evaluated. Patients' characteristics and clinical factors were evaluated for their association with sac enlargement. RESULTS: Fifty-five patients underwent TAE with technical success and were subsequently followed for a median of 636 (interquartile ranges 446-1292) days. The freedom from sac enlargement rates at 1, 3, and 5 years was 73.2%, 32.0%, and 26.7%, respectively. After initial TAE, the recurrent type II, delayed type I, and occult type III endoleak were identified in 39 (71%), 5 (9%), and 3 (5%) patients, respectively. Although a patient had aorto-duodenal fistula, there was no aneurysm-related death. The freedom from reintervention rates was 84.6%, 35.7%, and 17.0%, respectively. In the multivariate analysis, sac diameter > 55 mm at initial TAE (hazard ratios, 3.23; 95% confidence intervals, 1.22-8.58; P < 0.05) was a significant predictor of sac enlargement. CONCLUSION: TAE for type II endoleak was not effective in preventing sac enlargement, and reinterventions were required among the mid-term follow-up. The sac diameter > 55 mm at initial TAE was a significant predictor of sac enlargement.2020年05月, Cardiovascular and interventional radiology, 43(5) (5), 696 - 705, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- PURPOSE: To assess the utility of whole-aorta CT angiography (CTA) with 15 mL contrast material (CM) on time-resolved imaging for endovascular abdominal aortic repair (EVAR). METHODS: Twenty-six patients with a high-risk of post-contrast acute kidney injury (PC-AKI) underwent CTA with 15 mL CM using temporal maximum intensity projection (tMIP-CTA) generated from time-resolved imaging. The aortoiliac CT values were measured. Two observers measured the arterial diameters in unenhanced CT and tMIP-CTA images, and image quality was evaluated on a 5-point scale. The presence of the accessory renal artery, inferior mesenteric artery (IMA) occlusion, and instructions for use (IFU) of EVAR were evaluated. RESULTS: CT examinations were successfully performed, and no patients developed PC-AKI. The mean CT values of the whole aorta were 267.5 ± 51.4 HU, which gradually decreased according to the distal levels of the aorta. Bland-Altman analysis revealed excellent agreement for the external arterial diameter measurements between unenhanced CT and tMIP-CTA. Excellent interobserver agreement was achieved for the measurements of the external (ICCs, 0.910-0.992) and internal arterial diameters (ICCs, 0.895-0.993). Excellent or good overall image quality was achieved in 24 (92 %) patients. The presence of the accessory renal artery, IMA occlusion and the assessment of IFU were in 100 % agreement. Multivariate analysis revealed aortic volume as the most significant independent factor associated with strong aortic enhancement (p = 0.004). CONCLUSIONS: Whole-aorta tMIP-CTA on time-resolved imaging is useful for maintaining contrast enhancement and image quality for EVAR planning, and can substantially reduce the amount of CM.2020年05月, European journal of radiology, 126, 108861 - 108861, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- OBJECTIVES: This study aimed to evaluate the diagnostic performance of the lung zero-echo time (ZTE) sequence in FDG PET/MRI for detection and differentiation of lung lesions in oncologic patients in comparison with conventional two-point Dixon-based MR imaging. METHODS: In this single-institution retrospective study approved by the institutional review board, 209 patients with malignancies (97 men and 112 women; age range, 17-89 years; mean age, 66.5 ± 12.9 years) underwent 18F-FDG PET/MRI between August 2017 and August 2018, with diagnostic Dixon and ZTE under respiratory gating acquired simultaneously with PET. Image analysis was performed for PET/Dixon and PET/ZTE fused images by two readers to assess the detectability and differentiation of lung lesions. The reference standard was pathological findings and/or the data from a chest CT. The detection and differentiation abilities were evaluated for all lesions and subgroups divided by lesion size and maximum standardized uptake value (SUVmax). RESULTS: Based on the reference standard, 227 lung lesions were identified in 113 patients. The detectability of PET/ZTE was significantly better than that of PET/Dixon for overall lesions, lesions with a SUVmax less than 3.0 and lesions smaller than 4 mm (p < 0.01). The diagnostic performance of PET/ZTE was significantly better than that of PET/Dixon for overall lesions and lesions smaller than 4 mm (p < 0.01). CONCLUSIONS: ZTE can improve diagnostic performance in the detection and differentiation of both FDG-avid and non-FDG-avid lung lesions smaller than 4 mm in size, yielding a promising tool to enhance the utility of FDG PET/MRI in oncology patients with lung lesions. KEY POINTS: • The detection rate of PET/ZTE for lesions with a SUVmax of less than 1.0 was significantly better than that of PET/Dixon. • The performance for differentiation of PET/ZTE for lesions that were even smaller than 4 mm in size were significantly better than that of PET/Dixon. • Inter-rater agreement of PET/ZTE for the differentiation of lesions less than 4 mm in size was substantial and better than that of PET/Dixon.2020年04月, European radiology, 30(9) (9), 4995 - 5003, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Although total tumour volume (TTV) may have prognostic value for hepatic resection in certain solid cancers, its importance in colorectal liver metastases (CRLM) remains unexplored. This study investigated its prognostic value in patients with resectable CRLM. METHOD: This was a retrospective review of patients who underwent hepatic resection for CRLM between 2008 and 2017 in a single institution. TTV was measured from CT images using three-dimensional construction software; cut-off values were determined using receiver operating characteristic (ROC) curve analyses. Potential prognostic factors, overall survival (OS) and recurrence-free survival (RFS) were determined using multivariable and Kaplan-Meier analyses. RESULTS: Some 94 patients were included. TTV cut-off values for OS and RFS were 100 and 10 ml respectively. Right colonic primary tumours, primary lymph node metastasis and bilobar liver metastasis were included in the multivariable analysis of OS; a TTV of 100 ml or above was independently associated with poorer OS (hazard ratio (HR) 6·34, 95 per cent c.i. 2·08 to 17·90; P = 0·002). Right colonic primary tumours and primary lymph node metastasis were included in the RFS analysis; a TTV of 10 ml or more independently predicted poorer RFS (HR 1·90, 1·12 to 3·57; P = 0·017). The 5-year OS rate for a TTV of 100 ml or more was 41 per cent, compared with 67 per cent for a TTV below 100 ml (P = 0·006). Corresponding RFS rates with TTV of 10 ml or more, or less than 10 ml, were 14 and 58 per cent respectively (P = 0·009). A TTV of at least 100 ml conferred a higher rate of unresectable initial recurrences (12 of 15, 80 per cent) after initial hepatic resection. CONCLUSION: TTV was associated with RFS and OS after initial hepatic resection for CRLM; TTV of 100 ml or above was associated with a higher rate of unresectable recurrence.2020年04月, BJS open[Epub ahead of print], 英語, 国際誌[査読有り]
- BACKGROUND: Differentiation between inflammation and fibrosis is an important clinical distinction in patients with chronic liver disease, which has been difficult so far with MR elastography. PURPOSE: To investigate whether dual-frequency MR elastography can estimate necroinflammation of the liver and improve diagnostic performance for the staging of liver fibrosis. STUDY TYPE: Retrospective. SUBJECTS: In all, 30 patients (14 males, 16 females) with chronic liver disease. FIELD STRENGTH/SEQUENCE: 1.5T/dual-frequency MR elastography at 60-Hz and 80-Hz vibration frequencies. [Correction added on November 12, 2019, after first online publication: The field strength in the preceding sentence was corrected.] ASSESSMENT: Necroinflammation activity and fibrosis were assessed using the METAVIR scoring system. Stiffness values at 60-Hz (G60-Hz ) and 80-Hz (G80-Hz ) were obtained with an MR elastogram. The difference value between G80-Hz and G60-Hz (ΔG) was calculated. Four values (G60-Hz , G80-Hz , G60-Hz - ΔG, and G80-Hz + ΔG) were generated to estimate necroinflammation and fibrosis. STATISTICAL TESTS: The ΔG were correlated with necroinflammation activity grade and fibrosis stage using Spearman's rank correlation. Diagnostic performance of the four values for necroinflammation activity grade and fibrous stage was assessed by using area under the receiver operating characteristic curve (AUC). RESULTS: The mean value of G80-Hz (6.23 ± 3.67 kPa) was significantly higher than that of G60-Hz (5.27 ± 3.14 kPa) (P < 0.0001). The ΔG demonstrated a strong correlation with necroinflammation grade (ρ = 0.625, P < 0.001) and no correlation with fibrosis stage (ρ = 0.306, P = 0.113). The AUC of the G80-Hz and G80-Hz + ΔG showed higher accuracy for necroinflammation, and optimal cutoff values yielded better discrimination of ≥A1, ≥A2, and = A3. The AUC demonstrated that all the generated values had high diagnostic performance (≥0.87 for all) for fibrosis. DATA CONCLUSION: Dual-frequency MR elastography shows potential in estimating necroinflammation of the liver and may improve diagnostic performance for staging liver fibrosis. LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:1053-1064.2020年04月, Journal of magnetic resonance imaging : JMRI, 51(4) (4), 1053 - 1064, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: The present study aimed to assess the clinical features of patients who received lenvatinib treatment for unresectable hepatocellular carcinoma (HCC). METHODS: The clinical characteristics, adverse events, and radiological responses were evaluated for 51 consecutive patients. RESULTS: Of the study subjects, 37 patients had Child-Pugh class A (CPA) liver function, and 14 patients had Child-Pugh class B (CPB) liver function. The overall response rates in the CPA and CPB groups were 42.9% and 25.0%, respectively, and disease control rates were 82.9% and 83.3%, respectively, without significant difference (p = 0.2621 and 0.9697). There was no significant difference between CPA and CPB groups regarding the incidence of adverse events, except for hepatic coma. No significant difference was observed in the relative dose intensity between the CPA and CPB groups, for the first month, 1-2 months, or 2-3 months (p = 0.2368, 0.9368, and 0.9293). CONCLUSION: The comparable outcomes between the CPA and CPB groups suggest the acceptability of lenvatinib treatment in patients with impaired liver function, at least in the acute phase. With careful follow-up, the dose can be relatively intensified, even in patients with impaired liver function and this may contribute to offering comparable treatment.2020年03月, HPB : the official journal of the International Hepato Pancreato Biliary Association, 22(10) (10), 1450 - 1456, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 日本消化器病学会-近畿支部, 2020年02月, 日本消化器病学会近畿支部例会プログラム・抄録集, 112回, 74 - 74, 日本語消化器がん薬物療法up to date 当院でのレンバチニブ導入症例の検討
- (公社)日本医学放射線学会, 2020年02月, Japanese Journal of Radiology, 38(Suppl.) (Suppl.), 40 - 40, 日本語線維軟骨塞栓症が疑われた若年者脊髄梗塞の1例[査読有り]
- (公社)日本医学放射線学会, 2020年02月, Japanese Journal of Radiology, 38(Suppl.) (Suppl.), 45 - 45, 日本語若年者に発症した中枢神経カンジダ髄膜炎の1例[査読有り]
- 2020年02月, Polich Journal of Radiology, 85, e67 - e81, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2020年01月, J Comput Assist Tomogr, 44(1) (1), 153 - 159[査読有り]研究論文（学術雑誌）
- Introduction: The underlying mechanism involved in the recurrence of hepatoma after hepatic arterial embolization (HAE) is not adequately examined. An immunosuppressive cytokine, transforming growth factor β1 (TGF-β1), can lead to tumor progression and is affected by hypoxia in various cancers. The study aimed to assess the effect of HAE on the expression of TGF-β1 in a rat hepatoma model. Methods: Sprague-Dawley rats bearing N1S1 hepatoma cells underwent HAE (HAE group, n = 5) or sham treatment (sham group, n = 4). The animals were euthanized at 48 h, and liver tissues were harvested. Immunohistochemistry (IHC) and quantitative polymerase chain reaction (qPCR) were performed to compare the expression of TGF-β1 and hypoxia-inducible factor 1α (HIF-1α) between the HAE and sham groups. In vitro experiments with the N1S1 cell line were also performed under normoxic (21% O2) or hypoxic (1% O2) conditions for 48 h, and the expression of TGF-β1 and HIF-1α was assessed with western blotting and enzyme-linked immunosorbent assay. Statistical data comparisons were performed by Student t test. Results: IHC showed that both the TGF-β1-positive and HIF-1α-positive tumor peripheral areas were larger in the HAE group (6.59 ± 2.49 and 10.26 ± 4.14%; p < 0.001, respectively) than in the sham group (0.34 ± 0.41 and 0.40 ± 0.84% respectively). Similarly, qPCR showed that the mRNA expression levels of TGF-β1 and HIF-1α were higher (1.95 ± 0.38-fold and 1.62 ± 0.37-fold; p < 0.001 and p = 0.002, respectively) in the HAE group than those in the sham group. TGF-β1 expression was suppressed when HIF-1α inhibitors were added (p = 0.001), and HIF-1α expression was upregulated when exogenous TGF-β1 was added (p = 0.033) in N1S1 cells. Conclusion: HAE enhanced local TGF-β1 expression in a rat hepatoma model. In vitro experiments suggest that HAE-induced hypoxic stress may trigger the interdependent expression of TGF-β1 and HIF-1α.2020年01月, Liver cancer, 9(1) (1), 63 - 72, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2019年12月, The American journal of surgical pathology, 43(12) (12), 1728 - 1731, 英語, 国際誌[査読有り]
- (一社)日本脈管学会, 2019年10月, 脈管学, 59(Suppl.) (Suppl.), S140 - S140, 日本語当院における脾動脈瘤に対する動脈塞栓術の治療成績[査読有り]
- (一社)日本脈管学会, 2019年10月, 脈管学, 59(Suppl.) (Suppl.), S175 - S175, 日本語Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績[査読有り]
- 日本臨床外科学会, 2019年10月, 日本臨床外科学会雑誌, 80(増刊) (増刊), 785 - 785, 日本語難治性胆汁漏後の胆管狭窄に対して狭窄部穿刺が有効であった一例[査読有り]
- BACKGROUND AND AIM: Chronic pancreatitis is a risk factor for pancreatic cancer. Pancreatic calcification is a characteristic of chronic pancreatitis; however, its significance for intraductal papillary mucinous neoplasm (IPMN) oncogenesis remains unknown. Therefore, we investigated the relationship between pancreatic calcification and invasive IPMN. METHODS: This study included 157 patients who underwent resection for IPMN between April 2001 and October 2016 (intraductal papillary mucinous adenoma, n = 76; noninvasive intraductal papillary mucinous carcinoma [IPMC], n = 32; and invasive IPMC, n = 49). We divided the subjects on the basis of the presence/absence of pancreatic calcification on preoperative computed tomography (CT). The factors associated with pancreatic calcification were investigated in univariate analyses. Then, multivariate logistic regression analyses of the relationship between pancreatic calcification and invasive IPMC (after adjusting for clinical or imaging characteristics) were conducted. RESULTS: Preoperative CT revealed pancreatic calcification in 17.2% (27/157) of the resected IPMN. In the univariate analyses, jaundice, high serum carbohydrate antigen 19-9 levels, and invasive IPMC were significantly associated with pancreatic calcification (4/27 [14.8%] vs 4/130 [3.1%], 0.01; 12/27 [44.4%] vs 31/130 [23.8%], 0.03; and 15/27 [55.6%] vs 34/130 [26.2%], 0.001, respectively). Pancreatic calcification was significantly associated with invasive IPMC (multivariate odds ratio = 2.88, 95% confidence interval [95% CI] = 1.15-7.21, 0.03, adjusted for clinical characteristics; odds ratio = 5.50, 95% CI = 1.98-15.3, 0.001, adjusted for imaging characteristics). CONCLUSIONS: Pancreatic calcification on CT is associated with invasive IPMC. Pancreatic calcification might be a predictor of invasive IPMC.2019年09月, Journal of gastroenterology and hepatology, 34(9) (9), 1648 - 1655, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- We recently experienced cases of pancreatobiliary-type intraductal papillary mucinous neoplasms (PB-IPMNs) with imaging features resembling pancreatic ductal adenocarcinomas (PDACs), and histologic appearance of purely pancreatobiliary morphology and highly distorted papillary growth, which led to the present study aiming to systematically investigate PB-IPMNs in comparison with PDACs. Surgical cases of PB-IPMNs (n = 31) and PDACs (n = 24) were examined. PB-IPMNs were classified into monotypic tumors (n = 12; 39%) consisting of entirely high-grade pancreatobiliary-type neoplastic cells and polytypic cases (n = 19; 61%) associated with components of low-grade dysplasia and/or other histologic types (eg, gastric, intestinal, or oncocytic types). Clinically, monotypic PB-IPMNs less commonly had dilatation of the ampullary orifice (0% versus 74%) and mucin hypersecretion (17% versus 89%) than did polytypic cases. In most cases of monotypic PB-IPMNs, cystic dilatation of the lesional ducts was less obvious on imaging; therefore, 33% were radiologically diagnosed as PDACs. Histologically, intraductal tumors in monotypic cases showed a highly complex papillary architecture with tubular/cribriform glands and irregular branching, and all these cases were associated with invasive malignancy. GNAS mutations were detected in polytypic PB-IPMNs (6/19; 32%), but there were no GNAS mutations in monotypic cases. The recurrence-free survival of patients with monotypic PB-IPMN or PDAC was similar and significantly worse than that of patients with polytypic PB-IPMN. In conclusion, some cases of monotypic PB-IPMNs lacked the classic characteristics of IPMNs and shared features with PDACs, raising the possibility that these cases may be better classified as a papillary variant of PDACs rather than IPMNs.2019年09月, Human pathology, 91, 26 - 35, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2019年09月, 日本インターベンショナルラジオロジー学会雑誌, 34(1) (1), 79 - 79, 日本語直腸静脈瘤に対して上直腸静脈直接穿刺法で塞栓術を行った1例[査読有り]
- A Vesical Imaging-Reporting and Data System (VI-RADS) based on multiparametric magnetic resonance imaging (mp-MRI) was developed to provide accurate information for the diagnosis of muscle-invasive bladder cancers (MIBCs). In this study we evaluated the interobserver agreement and diagnostic performance of VI-RADS. We retrospectively evaluated data for 74 consecutive patients with bladder cancer who had undergone mp-MRI before transurethral resection in a single institution from January 2010 to August 2018. Five readers assessed the probability of the presence of MIBC using VI-RADS scores. The interobserver agreement was assessed by measuring intraclass correlation coefficients (ICCs). Receiver operating characteristic (ROC) analysis was used to evaluate the MIBC diagnostic performance. The area under the ROC curve (AUC) was estimated for ordinal score assessments. Our study demonstrated that interobserver agreement was excellent among five readers (ICC 0.85, 95% confidence interval 0.80-0.89) and the diagnostic performance of VI-RADS was represented as a pooled AUC of 0.90 (95% confidence interval 0.87-0.93). PATIENT SUMMARY: We evaluated the interobserver agreement and diagnostic performance of a new scoring system based on magnetic resonance imaging called a Vesical Imaging-Reporting and Data System (VI-RADS) for muscle-invasive bladder cancer. Our results indicate that VI-RADS is suitable as a comprehensive tool for appropriate treatment planning for patients with bladder cancer.2019年07月, European urology, 76(1) (1), 54 - 56, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2019年05月, Case Reports in Gastroenterology, 13(2) (2), 265 - 270[査読有り]研究論文（学術雑誌）
- PURPOSE: To evaluate the incidence of type II endoleak (EL-II) and aneurysm enlargement after endovascular aneurysm repair (EVAR) using the Endurant stent graft in patients with abdominal aortic aneurysm (AAA) with occluded inferior mesenteric artery (IMA). MATERIALS AND METHODS: Between 2012 and 2017, 103 patients who underwent EVAR using the Endurant stent graft for AAA with occluded IMA (50 patients with prophylactic embolized IMA and 53 with spontaneous occluded IMA) were retrospectively reviewed. The incidence of EL-II and aneurysm enlargement was evaluated. Predictive factors for persistent EL-II were evaluated based on patient characteristics, preprocedural anatomical characteristics, intraprocedural details, and postprocedural complications. RESULTS: Incidence rates of early EL-II and persistent EL-II were 6.8% (7/103 patients) and 4.9% (5/103 patients), respectively. Aneurysm enlargement was found in 10 patients (9.7%), including all 5 patients with persistent EL-II, 3 with de novo EL-II, and 2 with no EL-II. The rates of freedom from aneurysm enlargement at 1, 2, and 3 years were 98.7%, 97.0%, and 93.1% for the group without persistent EL-II, and 80.0%, 60.0%, and 20.0% for the group with persistent EL-II (p < 0.001), respectively. The maximum aneurysm diameter (odds ratio (OR), 1.16; 95% confidence interval (CI), 1.01-1.34; p = 0.0362) and the number of patent lumbar arteries (OR, 2.72; 95% CI, 1.07-6.90; p = 0.0357) were predictive of persistent EL-II. CONCLUSIONS: The incidence of EL-II after EVAR using the Endurant stent graft for AAA with occluded IMA was low, but most early EL-II persisted and resulted in aneurysm enlargement. Level of Evidence Level 4, Case Series.2019年04月, Cardiovascular and interventional radiology, 42(4) (4), 505 - 512, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- PURPOSE: To evaluate the advantages of intraprocedural CT during adrenal venous sampling (AVS) to confirm accurate catheterization of the right adrenal vein (RAV). MATERIALS AND METHODS: This single-institution study included 106 patients (mean age 52.4 years; range 28-74 years) with primary aldosteronism who performed contrast-enhanced CT (CECT) before AVS following AVS between January 2011 and March 2018. After catheterization of the RAV under fluoroscopic guidance, unenhanced CT images were obtained to confirm catheter position on unified CT angiography system. Catheter repositioning was performed when the catheter was inaccurately positioned. Venography findings were classified into two groups: (1) presumably cannulated in the RAV (presumed RAV group) and (2) obscured visualization of the RAV because of collateral vessels (obscured RAV group). Success rates of AVS were compared using Fisher's exact test. RESULTS: The overall success of AVS was achieved in 104 patients (98.1%). Catheter was deviated into the IVC during intraprocedural CT in four patients. Fourteen patients (14.0%) required catheter repositioning by intraprocedural CT images, and accurate catheterization in the RAV was eventually accomplished. The success rate of AVS was significantly higher in the presumed RAV group (90.1% [73/81]) than that in the obscured RAV group (68.4% [13/19]) (p = 0.024). If intraprocedural CT was not acquired during AVS, the success rate of AVS would have been significantly lower (84.9% [90/106]) compared with that use of intraprocedural CT (98.1% [104/106]) (p < 0.001). CONCLUSIONS: Intraprocedural unenhanced CT by referring to the preprocedural CECT before AVS enables the confirmation of accurate catheterization of the RAV. LEVEL OF EVIDENCE: Level 4, case series.2019年04月, Cardiovascular and interventional radiology, 42(4) (4), 542 - 551, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- PURPOSE: To assess the safety and efficacy of transarterial embolization (TAE) and to evaluate the utility of contrast-enhanced computed tomography (CE-CT) for life-threatening spontaneous retroperitoneal hemorrhage (SRH). METHODS: Nineteen patients underwent TAE following CE-CT for life-threatening SRH. CE-CT and angiographic findings, technical successes, and clinical successes were evaluated. The diagnostic performance of CE-CT for the detection of active bleeding arteries was also assessed by two independent readers. RESULTS: Active extravasation of contrast material was accurately observed in 78.9‒84.2% of the patients on CE-CT. Angiograms revealed active extravasation in 37 arteries of 15 patients (78.9%), and 4 patients showed no sign of active bleeding. Sensitivity, positive predictive value, and accuracy rate of CE-CT for the detection of active bleeding vessels was 59.5%, 62.9‒71.0% and 55.6‒60.0% respectively. The successful embolization of 48 intended arteries was achieved in all the patients, including empirical TAE in four patients. Hemodynamic stabilization was achieved in 17 patients (89.5%) with a significant decrease in transfusion (p < 0.001). CONCLUSION: TAE is a technically safe and clinically effective treatment method for life-threatening SRH. CE-CT has moderate capability for accurate identification of active bleeding arteries. TAE including arteries that potentially distribute anatomic territory of the hematoma is essential.2019年04月, Japanese journal of radiology, 37(4) (4), 328 - 335, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2019年04月, 日本インターベンショナルラジオロジー学会雑誌, 33(4) (4), 445 - 460, 日本語IVR手技施行に関する診療体制についての提言
- (一社)日本インターベンショナルラジオロジー学会, 2019年04月, 日本インターベンショナルラジオロジー学会雑誌, 33(4) (4), 461 - 471, 日本語骨盤骨折に対するIVR施行医のためのガイドライン2017
- (株)Gakken, 2019年04月, 画像診断, 39(6) (6), 623 - 631, 日本語[査読有り]
- (株)メジカルビュー社, 2019年04月, 臨床画像 - 特集:症候別画像診断プロトコル -, 35(4) (4), 180 - 181, 日本語[査読有り]
- BACKGROUND: Growing evidence has suggested that intrahepatic cholangiocarcinoma (iCCA) can be classified into small- and large-duct types. The present study aimed to elucidate how large-duct iCCA is similar and dissimilar to perihilar cholangiocarcinoma (pCCA). METHODS: The study cohort consisted of iCCA (n = 58) and pCCA (n = 44). After iCCA tumors were separated into small- (n = 36) and large-duct (n = 22) types based on our histologic criteria, genetic statuses of the three types of neoplasms were compared. Locations of iCCA were plotted on a three-dimensional image and their distances from the portal bifurcation were measured. RESULTS: Large-duct iCCA was distinct from small-duct iCCA in terms of frequency of bile duct reconstruction required, perineural infiltration, and survival, with these features more similar to pCCA. Large-duct iCCA and pCCA more frequently had the loss of SMAD4 expression and MDM2 amplifications than small-duct iCCA, whereas the loss of BAP1 expression and IDH1 mutations were mostly restricted to small-duct iCCA. From imaging analysis, most tumors of large-duct iCCA were present around the second branches of the portal vein. CONCLUSION: Large-duct type iCCA shared the molecular features with pCCA, and it may be reasonable to expand the definition of pCCA to include cancers originating from the second bile duct branches.2019年02月, HPB : the official journal of the International Hepato Pancreato Biliary Association, 21(2) (2), 226 - 234, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Springer Verlag, 2019年, Medical Radiology, 447 - 489, 英語論文集(書籍)内論文
- OBJECTIVE:: To devise a simple new technique wherein absolute ethanol is injected via a sheath under proximal balloon occlusion of the right portal vein using a single-balloon catheter and to examine its feasibility and safety for ipsilateral portal vein embolization (PVE). METHODS:: Between 2010 and 2016, PVE was performed in 19 patients prior to undergoing extended right hepatectomy. PVE was performed via a percutaneous transhepatic ipsilateral approach, the right portal branch was embolized under ultrasound guidance, and a balloon catheter was placed in the proximal site of the main right portal branch. Absolute ethanol was injected through a sheath under proximal balloon occlusion of the right portal vein using a double-lumen catheter. We evaluated its technical success and complications following PVE and changes in liver enzyme levels. Furthermore, we calculated changes in future liver remnant (FLR) and FLR/total functional liver volume (TFLV) ratio and assessed complications following hepatic resection. RESULTS:: PVE was successfully performed in all patients. Mean FLR and FLR/TFLV significantly increased following PVE (p < 0.01). The change in the FLR and FLR/TFLV ratio was 39.6 ± 16.2%. One patient (6.5%) developed procedure-related complications following PVE (perihepatic hematoma). CONCLUSION:: The new technique for ipsilateral right PVE is safe, effective, and convenient. ADVANCES IN KNOWLEDGE:: This is the first study to investigate the efficacy of injecting ethanol via a sheath under proximal balloon occlusion of the right portal vein using a single-balloon catheter.2018年12月, The British journal of radiology, 91(1092) (1092), 20180124 - 20180124, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2018年12月, 臨床放射線, 63(12) (12), 122 - 125[査読有り]
- OBJECTIVE: The aim of this study was to assess the ability of third-generation dual-source dual-energy computed tomography to quantify cisplatin concentration using a 3-material decomposition algorithm in an experimental phantom. MATERIALS AND METHODS: Fifteen agarose-based phantoms containing various concentrations of iodine (0, 1.0, 2.0 mg I/mL) and cisplatin (0, 0.5, 1.0, 2.0, 3.0 mg Pt/mL) were scanned using third-generation dual-source dual-energy computed tomography at 80 kV and 150 kV with tin prefiltration. A cisplatin map was generated using the cisplatin-specific 3-material decomposition algorithm to differentiate cisplatin from iodine and agar. The computed tomography (CT) values at 80 kV, 150 kV, mixed 120 kV, and the cisplatin map were measured. Interobserver variabilities for the CT measurements on the cisplatin map were assessed using interclass correlation coefficients. Correlation between the CT values and titrated cisplatin concentrations was correlated using Spearman rank correlation analysis. To assess the influence of iodine, linear regression lines for the CT values on the cisplatin map and titrated cisplatin concentrations were compared using an analysis of covariance. RESULTS: Interobserver agreement revealed almost perfect agreements (interclass correlation coefficients = 0.941-0.995). Significant and excellent positive correlations were observed between the CT values on the cisplatin map and titrated cisplatin concentrations (ρ = 0.980, P < 0.001 for all). The cisplatin map could identify the lowest cisplatin concentration of 0.5 mg Pt/mL in the presence of iodine. The iodine concentration had no significant effect on the CT measurements on the cisplatin map (P = 0.297, adjusted R = 0.993). CONCLUSIONS: The cisplatin map generated from the 3-material decomposition algorithm allows quantification of a cisplatin concentration in an experimental phantom, independent of co-present iodine.2018年11月, Invest Radiol, 53(11) (11), 673 - 680, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- AIM: To investigate whether iodine density measurements from contrast-enhanced dual-energy computed tomography (CT) data can non-invasively stage liver fibrosis. METHODS: This single-center, prospective study was approved by our IRB with written informed consent. Forty-seven consecutive patients (26 men and 21 women; mean age, 63.1 years) with chronic liver disease underwent contrast-enhanced dual-energy CT of the liver (non-contrast, arterial, portal venous, and equilibrium phase images), followed by liver biopsy. Iodine density of liver and aorta were obtained by two independent observers. Iodine uptake of the liver (Δ Liver), representing the difference in iodine density between equilibrium phase and non-contrast images, was calculated and normalized by aorta (Δ Liver/Aorta). We accounted for contrast agent distribution volume by using hematocrit level. Accuracy of iodine density measurements for staging liver fibrosis was assessed by using receiver operating characteristic (ROC) curves. Multivariate linear regression analysis was used to assess the impact of independent variables (liver fibrosis stage and patient-related confounders) on iodine uptake. RESULTS: The Δ Liver/Aorta significantly increased and moderately correlated with METAVIR liver fibrosis stage (ρ = 0.645, P < 0.001). Areas under the ROC curve ranged from 0.795 to 0.855 for discriminating each liver fibrosis score (≥F1-F4). METAVIR fibrosis stage was the most significant independent factor associated with Δ Liver (P = 0.005) and Δ Liver/Aorta (P < 0.001). CONCLUSION: Hepatic extracellular volume fraction with contrast-enhanced dual-energy CT can non-invasively stage liver fibrosis in chronic liver diseases. This technique could prove useful for monitoring disease progression and treatment response, potentially reducing the need for liver biopsy.2018年11月, Hepatol Res, 48(12) (12), 1008 - 1019, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Radiation therapy is a useful treatment for tumors and vascular malformations of the central nervous system. Radiation therapy is associated with complications, including leukoencephalopathy, radiation necrosis, vasculopathy, and optic neuropathy. Secondary tumors are also often seen long after radiation therapy. Secondary tumors are often benign tumors, such as hemangiomas and meningiomas, but sometimes malignant gliomas and soft tissue sarcomas emerge. We review the imaging findings of complications that may occur after brain radiation therapy.2018年09月, Japanese journal of radiology, 36(9) (9), 519 - 527, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- 2018年09月, KOREAN JOURNAL OF RADIOLOGY, 19(5) (5), 832 - 837, 英語[査読有り]
- 2018年09月, Br J Radiol, ePub, 英語[査読有り]研究論文（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2018年08月, IVR: Interventional Radiology, 33(2) (2), 165 - 194, 日本語産科危機的出血に対するIVR施行医のためのガイドライン2017 2012の部分改訂
- We aimed to compare 11C-choline positron emission tomography/computed tomography (PET/CT) with conventional imaging, including pelvic magnetic resonance imaging (MRI), contrast-enhanced chest, abdomen, and pelvic computed tomography (CT), and bone scintigraphy, for prostate cancer restaging. Thirty patients (median prostate-specific antigen [PSA: 11.8 ng/mL]) with suspected recurrent prostate cancer following definitive treatment underwent 11C-choline PET/CT and conventional imaging, including pelvic MRI, contrast-enhanced chest, abdomen, and pelvic CT, and bone scintigraphy. The results were compared with regard to patient- and lesion-based diagnostic performance for local recurrence, and for lymph node and bony metastases using receiver operating characteristic (ROC) analysis and McNemar's test. Documented local recurrence and node and bony metastases were present in 11 (36.7%), 10 (33.3%), and 17 (56.7%) cases, respectively, of the enrolled patients. Patient-based sensitivity / specificity / accuracy / area under the ROC curve for 11C-choline-PET/CT for diagnosing local recurrence were 90.9% / 94.7% / 93.3% / 0.975 and for conventional imaging were 90.9% / 100% / 96.7% / 1.0. Those who underwent 11C-choline-PET/CT for node metastasis were 90.0% / 95.0% / 93.3% / 0.925 and for conventional imaging were 70.0% / 95.0% / 86.7% / 0.905. Those who underwent 11C-choline-PET/CT for bone metastasis were 94.1% / 92.3% / 93.3% / 0.991 and who underwent conventional imaging were 94.1% / 84.6% / 90.0% / 0.982. No significant differences were observed among them. The lesion-based detection rate of 11C-choline PET/CT for local recurrences and node and bone metastases as compared to conventional imaging was 92.9% (13/14) vs. 92.9% (13/14); 87.1% (27/31) vs. 54.8% (17/31); and 96.9% (219/226) vs. 90.3% (204/226) respectively, with significant differences noted for detection of node and bone lesions (p=0.0044 and p=0.00030, respectively). 11C-choline-PET/CT is more accurate in the detection of recurrent prostate cancer nodes and bony metastatic lesions compared to conventional imaging and has the advantage of restaging the disease in a single step.2018年07月, Cureus, 10(7) (7), e2966, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2018年07月, Jpn J Radiol, 36(9) (9), 519 - 527, 英語[査読有り]研究論文（学術雑誌）
- PURPOSE: To justify a classification system for angiographic images of uterine artery embolization (UAE) for postpartum hemorrhage (PPH) and identify new risk factors associated with failed embolization. MATERIALS AND METHODS: A retrospective analysis of 63 consecutive patients who underwent UAE for severe PPH was performed. Uterine artery angiography (UA) before embolization was classified into two types: type 1 was defined as complete staining and type 2 was defined as partial staining of the uterine arteries. The clinical outcome, UA classification, and other possible factors previously reported were evaluated. Univariate and multivariate analyses were performed to determine the factors related to clinical outcomes. RESULTS: Sixty-three patients were enrolled (type 1, 22; type 2, 41). The clinical success rates of the primary UAE session were 90.9% (20/22) for type 1 and 61.0% (25/41) for type 2 (p = 0.018). Univariate and multivariate analyses demonstrated that the only UA classification was significantly associated with primary UAE failure (p = 0.033). CONCLUSIONS: The UA classification is an independent predictive factor of the clinical success rate of the primary UAE session for PPH; thus, it is an intuitive and optimal predictor for interventional radiologists to decide whether additional therapy is necessary.2018年06月, Japanese journal of radiology, 36(6) (6), 394 - 400, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- OBJECTIVES: The present study was conducted in order to elucidate the relationship between the number of cyst-existing regions and incidence of pancreatic ductal adenocarcinoma (PDAC) concomitant with intraductal papillary mucinous neoplasm (IPMN), which currently remains unclear. METHODS: Subjects comprised 141 patients undergoing resection for IPMN (Non-invasive IPMN (IPMN with low-to high-grade dysplasia): N = 94, invasive IPMN: N = 31, and PDAC concomitant with IPMN: N = 16) between November 2000 and February 2017. A logistic regression analysis was performed to assess the relationship between the number of cyst-existing regions (one region/two or more regions) and incidence of PDAC concomitant with IPMN, adjusted by clinical characteristics. Cyst-existing regions were defined by the number of anatomical parts of the pancreas: the head/body/tail of the pancreas. RESULTS: Multiple cyst-existing regions (two or more regions) correlated with the incidence of PDAC concomitant with IPMN (PDAC concomitant with IPMN in one region vs. two or more regions: 3/66 vs. 13/75, multivariable odds ratio [OR] = 4.11, 95% confidence interval [CI] = 1.22 to 18.8, P = 0.02). In contrast, multiple cyst-existing regions did not correlate with the incidence of IPMN (invasive IPMN in one region vs. two or more regions: 13/66 vs. 18/75, OR = 1.19, 95% CI = 0.52 to 2.76, P = 0.67). CONCLUSIONS: Multifocal cysts correlated with the incidence of PDAC concomitant with IPMN, and may be a high-risk factor for PDAC concomitant with IPMN.Elsevier {BV}, 2018年06月, Pancreatology, 18(4) (4), 399 - 406, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2018年06月, Investigative Radilogy, 英語[査読有り]研究論文（学術雑誌）
- (株)日本メディカルセンター, 2018年05月, 臨床消化器内科, 33(6) (6), 599 - 602, 日本語[査読有り]
- (一社)日本インターベンショナルラジオロジー学会, 2018年04月, IVR: Interventional Radiology, 33(Suppl.) (Suppl.), 190 - 190, 英語右副腎静脈を確認するための副腎静脈サンプリング中血管造影CTの有用性(The utility of Angio-CT during adrenal venous sampling to confirm the right adrenal vein)
- (一社)日本インターベンショナルラジオロジー学会, 2018年04月, IVR: Interventional Radiology, 33(Suppl.) (Suppl.), 191 - 191, 英語血管過多性脊髄腫瘍の部分切除のための術前塞栓術の実行可能性(The feasibility of preoperative embolization for partial resection of hypervascular spinal tumor)
- (一社)日本インターベンショナルラジオロジー学会, 2018年04月, IVR: Interventional Radiology, 33(Suppl.) (Suppl.), 227 - 227, 英語膵および膵周囲動脈の急性出血に対するNBCA塞栓術(Embolization with NBCA for acute bleeding of pancreatic and peripancreatic arteries)
- 2018年04月, Pancreatology, 18(4) (4), 399 - 406, 英語[査読有り]研究論文（学術雑誌）
- 2018年04月, Jpn J Radiol, 36(6) (6), 394 - 400, 英語[査読有り]研究論文（学術雑誌）
- BACKGROUND: The prognostic impact of pancreatic ductal adenocarcinoma (PDAC) invasion to the splenic vessel is controversial. OBJECTIVE: The aim of this study was to assess the clinical value of pathological and radiological splenic vessel invasion in PDACs of the body and tail. METHODS: Medical records of patients with resectable PDAC of the body and tail who underwent distal pancreatectomy between 2003 and 2016 at the Kobe University Hospital were retrospectively analyzed. RESULTS: Overall, 68 patients (29 female and 39 male patients) were enrolled. Pathologically determined splenic vein invasion (p-SV) and splenic artery invasion (p-SA) were identified in 21 (30.9%) and 5 (7.4%) patients, respectively. The p-SV (but not p-SA) was an independent prognostic factor in multivariate analysis (p = 0.009). On analysis of recurrence patterns, patients with PDAC positive for p-SV were at a higher risk for liver metastasis (p = 0.022); however, the associations were not significant for other recurrence patterns. Liver metastasis occurred earlier in patients who were positive for p-SV (p = 0.015). Preoperative computed tomography effectively diagnosed pathological vessel invasion (SV: sensitivity, 95.2%, specificity, 72.3%; SA: sensitivity, 100%, specificity, 84.1%). Radiological SV invasion remained significant in multivariate analysis regarding postoperative survival (p = 0.007), and was also associated with early liver metastases (p = 0.008). CONCLUSIONS: Pathological/radiological SV invasion were independent adverse prognostic factors associated with early liver metastasis in patients with PDAC of the body/tail. Assessment of these findings may be useful in determining optimal therapeutic options in these patients.2018年03月, Annals of surgical oncology, 25(3) (3), 638 - 646, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- OBJECTIVE: To compare the length of the membranous (functional) urethra in male patients who underwent the male transobturator sling (TOS) for postradical prostatectomy urinary incontinence (PPI). The TOS is in established use for treatment of PPI; however, the precise mechanism of action is unknown. MATERIALS AND METHODS: This is a prospective case-controlled study on men undergoing male TOS surgery from 2008 to 2014. The comparison arm included patients without incontinence after radical prostatectomy. All participants underwent dynamic magnetic resonance imaging (MRI) at baseline and this was repeated after TOS placement for those who underwent the procedure. Three standardized points were measured using MRI and compared in both groups in addition to clinical measures. RESULTS: Thirty-nine patients were enrolled and 31 patients completed the protocols. The controls (N = 14) had a longer vesicourethral anastomosis to urethra measured at the penile bulb (functional urethral length) distance compared to the pre-TOS group at rest (1.92 cm controls vs 1.27 cm pre-TOS, P = .0018) and at Valsalva (2.13 cm controls vs 1.72 cm pre-TOS, P = .0371). Placement of the sling (N = 17) increased the functional urethral length distance at rest (1.92 cm control vs 1.53 cm post-TOS, P = .09) and at Valsalva (1.94 cm post-TOS vs 2.13 cm control, P = .61), so that the difference was no longer statistically significant. CONCLUSION: We identified that one possible mechanism in improvement in stress urinary incontinence post-TOS placement is the lengthening of the vesicourethral anastomosis to bulbar-urethra distance. This is the first such study utilizing dynamics MRI in post prostatectomy controls, incontinent pre-TOS, and post-TOS to assess and show these findings.2018年03月, Urology, 116, 185 - 192, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2018年02月, IVR会誌, 33(2) (2), 137 - 143, 日本語IVR後の画像診断 Ch. 5 金属コイルを用いた動脈塞栓術後の画像診断[査読有り]
- (株)日本臨床社, 2018年02月, 日本臨床, 76(2) (2), 211 - 217, 日本語[査読有り]
- BACKGROUND: Inflammation-induced carcinogenesis in pancreatic ductal adenocarcinoma (PDAC) has been reported; however, its involvement in PDAC with intraductal papillary mucinous neoplasm (IPMN) remains unclear. We herein investigated the relationship between pancreatic atrophy and inflammation and the incidence of PDAC concomitant with IPMN. METHODS: This study included 178 consecutive patients who underwent surgical resection for PDAC with IPMN (N = 21) and IPMN (N = 157) between April 2001 and October 2016. A multivariable logistic regression analysis was conducted to assess the relationship between pancreatic inflammation and atrophy and the incidence of PDAC concomitant with IPMN, with adjustments for clinical characteristics and imaging features. Pathological pancreatic inflammation and atrophy were evaluated in resected specimens. RESULTS: High degrees of pancreatic inflammation and atrophy were not associated with the incidence of PDAC with IPMN (multivariable odds ratio [OR] = 0.5, 95% confidence interval [CI] = 0.07 to 3.33, P = .52, adjusted by clinical characteristics, OR = 0.9, 95% CI = 0.10 to 5.86, P = .91, adjusted by imaging studies; OR = 0.2, 95% CI = 0.009 to 1.31, P = .10, adjusted by clinical characteristics, OR = 0.2, 95% CI = 0.01 to 1.43, P = .12, adjusted by imaging studies, respectively). CONCLUSIONS: Pancreatic inflammation and atrophy were not associated with pancreatic cancer concomitant with IPMN.Elsevier {BV}, 2018年01月, Pancreatology, 18(1) (1), 54 - 60, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2017年12月, JAPANESE JOURNAL OF RADIOLOGY, 35(12) (12), 707 - 717, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) often infiltrates to the adjacent major vasculatures; however, direct invasion of PDAC to the inferior vena cava (IVC) is uncommon. CASE PRESENTATION: We report our experience with three cases of PDAC directly invading the IVC wall. All three patients underwent pancreatoduodenectomy along with wedge resection of the IVC wall without severe postoperative complications. Histopathological studies revealed tumor infiltration to the adventitia of the IVC. All patients achieved negative surgical margins. One patient was still alive 26 months after surgery without tumor recurrence. Two patients experienced recurrence; one patient experienced liver metastasis but was still alive and in a stable condition without further tumor progression 12 months after surgery. Another patient experienced multiple liver metastasis 10 months after surgery and died 26 months after surgery. CONCLUSIONS: Pancreatoduodenectomy along with wedge resection of the IVC wall for patients with PDAC directly invading the adventitia of the IVC can be performed safely. Further accumulation of cases is needed to elucidate the prognostic impact of IVC invasion.2017年12月, Surgical case reports, 3(1) (1), 72 - 72, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2017年11月, PANCREATOLOGY, 17(6) (6), 956 - 961, 英語[査読有り]研究論文（学術雑誌）
- Positron emission tomography/computed tomography (PET/CT) integrated with 2-[18F]fluoro-2-deoxy-D-glucose (FDG) is a useful tool for acquisition of both glucose metabolism and anatomic imaging data, as only a single device and one diagnostic session is required, thus opening a new field in clinical oncologic imaging. FDG-PET/CT has been successfully used for initial staging, restaging, assessment of early treatment response, evaluation of metastatic disease response, and prognostication of intestinal cancer as well as various malignant tumors. We reviewed the current status and role of FDG-PET/CT for management of patients with esophageal cancer, gastric cancer, and colorectal cancer, with focus on both its usefulness and limitations.2017年11月, Nagoya journal of medical science, 79(4) (4), 527 - 543, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- 2017年09月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 46(3) (3), 783 - 792, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- The present study aimed to evaluate the efficacy of an intra-arterially infused carbon dioxide (CO2)-saturated solution in sensitizing the anticancer effect of cisplatin in a rabbit VX2 liver tumor model. Forty VX2 liver tumor-bearing Japanese white rabbits were randomly divided into four groups and infused via the proper hepatic artery with a saline solution (control group), CO2-saturated solution (CO2 group), cisplatin solution (cisplatin group), or CO2-saturated solution and cisplatin solution (combined group). The tumor volume (TV) and the relative tumor volume (RTV), RTV = (TV on day 3 or 7)/(TV on day 0) x 100, were calculated using contrast-enhanced computed tomography. Hypoxia-inducible factor-1α (HIF‑1α) and carbonic anhydrase IX (CA IX) staining were used to evaluate cellular hypoxia. Cleaved caspase-3 and cleaved caspase-9 were analyzed to assess tumor apoptosis. The mean RTV on days 3 and 7 were 202.6±23.7 and 429.2±94.8%, respectively, in the control group; 172.2±38.1 and 376.5±61.1% in the CO2 group; 156.1±15.1 and 269.6±45.2% in the cisplatin group; and 118.3±28.1 and 210.3±55.1% in the combined group. RTV was significantly lower in the CO2 group than in the control group (day 3; P<0.05), and in the combined group than in the cisplatin group (days 3 and 7; P<0.05). HIF-1α and CA IX suppression, and increased cleaved caspase-3 and cleaved caspase-9 expression, were detected in the CO2 and combined groups, compared with the other two groups. An intra-arterially infused CO2-saturated solution inhibits liver VX2 tumor growth and sensitizes the anticancer effect of cisplatin.2017年08月, International journal of oncology, 51(2) (2), 695 - 701, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2017年07月, EUROPEAN RADIOLOGY, 27(7) (7), 2978 - 2988, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2017年06月, ABDOMINAL RADIOLOGY, 42(6) (6), 1659 - 1666, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2017年05月, INVESTIGATIVE RADIOLOGY, 52(5) (5), 274 - 280, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2017年04月, MAGNETIC RESONANCE IN MEDICINE, 77(4) (4), 1516 - 1524, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2017年04月, JAPANESE JOURNAL OF RADIOLOGY, 35(4) (4), 197 - 205, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2017年04月, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 116 - 116, 日本語血管塞栓術に用いるNBCAのガイドライン2012[査読有り]
- Elsevier {BV}, 2017年01月, Pancreatology, 17(1) (1), 123 - 129, 英語[査読有り]研究論文（学術雑誌）
- 2017年, Pancreas, 46(4) (4), 582 - 588, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2016年10月, ANNALS OF SURGICAL ONCOLOGY, 23(11) (11), 3623 - 3631, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Elsevier {BV}, 2016年09月, Pancreatology, 16(5) (5), 893 - 899, 英語[査読有り]研究論文（学術雑誌）
- 2016年09月, ABDOMINAL RADIOLOGY, 41(9) (9), 1758 - 1766, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2016年08月, ABDOMINAL RADIOLOGY, 41(8) (8), 1555 - 1564, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2016年08月, HEPATOLOGY RESEARCH, 46(9) (9), 853 - 861, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)日本消化器外科学会, 2016年07月, 日本消化器外科学会総会, 71回, P3 - 2, 日本語膵神経内分泌腫瘍 CTにおける造影パターンと臨床病理学的所見の相関[査読有り]
- 2016年06月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 43(6) (6), 1337 - 1345, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2016年05月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 43(5) (5), 1073 - 1081, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2016年01月, JOURNAL OF GASTROENTEROLOGY, 51(1) (1), 71 - 79, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- 2015年11月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 42(5) (5), 1281 - 1290, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2015年10月, JOURNAL OF PEDIATRIC SURGERY, 50(10) (10), 1707 - 1710, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2015年07月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 39(4) (4), 506 - 509, 英語[査読有り]研究論文（学術雑誌）
- 2015年07月, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 42(8) (8), 1268 - 1275, 英語[査読有り]研究論文（学術雑誌）
- 2014年12月, SURGERY TODAY, 44(12) (12), 2366 - 2368, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- Endovascular treatment for arteriocaval fistula (ACF) has become the preferred alternative to open repair. However, endoleaks sometimes occur and maintain the ACF. A 64-year-old man presented with persistent fistula after placement of a bifurcated stent-graft for ACF complicating an aortoiliac aneurysm that was maintained by endoleaks from the inferior mesenteric and lumbar arteries. Transarterial embolization of the aneurysm sac and inferior mesenteric artery successfully resolved the problem without any complications observed over 16 months of follow-up. A literature review and discussion of the management options for this entity are presented. A combination of inflow and outflow control is important to obtain better long-term outcomes.2014年11月, Journal of vascular and interventional radiology : JVIR, 25(11) (11), 1809 - 15, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2014年10月, EUROPEAN RADIOLOGY, 24(10) (10), 2532 - 2539, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2014年08月, BRITISH JOURNAL OF SURGERY, 101(9) (9), 1122 - 1128, 英語[査読有り]研究論文（学術雑誌）
- Ectopic variceal hemorrhage caused by sinistral portal hypertension after splenic vein ligation during a pyloric-preserving pancreatoduodenectomy is a rare entity. We report the case of a 58-year-old man with symptoms of refractory melena. The varices could not be treated endoscopically and surgery was considered unsuitable due to severe adhesions and altered anatomy. Following clinical failure of partial splenic embolization, an alternative obliteration method by a retrograde trans-portal-venous approach was successfully performed and resolved the problem. It seems to be an effective method for ectopic variceal bleeding, especially when other interventions are unavailable or highly risky.2014年08月, Japanese journal of radiology, 32(8) (8), 487 - 90, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- PURPOSE: To evaluate the efficacy of intraarterial infusion of CO2-saturated solution in rabbit VX2 thigh tumors. MATERIALS AND METHODS: Fourteen Japanese white rabbits had VX2 tumors implanted in the right femoral muscle 3 weeks before intraarterial infusion. Rabbits were divided into control and CO2 groups (n = 7 each). Fifty milliliters of solution (saline solution and CO2-saturated solution for the control and CO2 groups, respectively) was administered via a 24-gauge catheter in the ipsilateral iliac artery close to the feeding artery of the VX2 tumor. All rabbits were killed for tumor harvest on day 3 after the procedure. Tumor volume was evaluated with in vivo direct caliper measurement and contrast-enhanced computed tomography (CT). Tumor apoptotic changes were examined by DNA fragmentation assay and immunoblot analysis. The tumor growth ratio and apoptotic cell rate were analyzed. RESULTS: Body weight was equally increased in both groups, but the mean tumor growth ratio was significantly decreased in the CO2 group compared with the control group (-9.5% ± 7.9 vs 27.2% ± 6.6 and 4.1% ± 4.4 vs 35.7% ± 4.5 measured by calipers and contrast-enhanced CT, respectively; P < .01). Apoptotic activity in the CO2 group was higher than in the control group (number of apoptotic cells per area, 215.0 ± 58.7 vs 21.8 ± 5.4; adjusted relative density of cleaved caspase-3, 0.23 ± 0.07 vs 0.04 ± 0.01; P < .01). CONCLUSIONS: Intraarterial infusion of CO2-saturated solution inhibits rabbit VX2 thigh tumor growth by activation of apoptotic cell death through cleaved caspase-3 upregulation.2014年03月, Journal of vascular and interventional radiology : JVIR, 25(3) (3), 469 - 76, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (公社)日本放射線技術学会, 2014年02月, 日本放射線技術学会総会学術大会予稿集, 70回, 279 - 279, 日本語上腹部ダイナミックCTにおけるボーラストラッキングの最適化
- 2013年11月, EUROPEAN JOURNAL OF RADIOLOGY, 82(11) (11), E691 - E696, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2013年10月, IVR: Interventional Radiology, 28(4) (4), 494 - 494, 日本語腹部大動脈瘤下大静脈穿破に対し緊急EVARおよび追加塞栓を施行した1例[査読有り]
- (一社)日本インターベンショナルラジオロジー学会, 2013年10月, IVR: Interventional Radiology, 28(4) (4), 492 - 492, 日本語腹腔動脈起始部狭窄に伴う下膵十二指腸動脈瘤破裂に対するTAE後に十二指腸狭窄をきたした1例[査読有り]研究論文（その他学術会議資料等）
- (一社)日本インターベンショナルラジオロジー学会, 2013年04月, IVR: Interventional Radiology, 28(Suppl.) (Suppl.), 185 - 185, 日本語内視鏡が通過しない高度狭窄を伴った食道癌患者における経皮的胃瘻造設術の検討
- 2013年02月, WORLD JOURNAL OF GASTROENTEROLOGY, 19(6) (6), 951 - 954, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2013年02月, CardioVascular and Interventional Radiology, 36(1) (1), 272 - 275, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2013年02月, IVR: Interventional Radiology, 28(1) (1), 108 - 108, 日本語出血性輸入脚静脈瘤に対し経皮経肝的B-RTOで治療し得た1例研究論文（その他学術会議資料等）
- 2012年10月, JAPANESE JOURNAL OF RADIOLOGY, 30(8) (8), 680 - 683, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- 2012年09月, WORLD JOURNAL OF SURGERY, 36(9) (9), 2192 - 2201, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2012年04月, JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 23(4) (4), 521 - 527, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2012年04月, EUROPEAN JOURNAL OF RADIOLOGY, 81(4) (4), 714 - 718, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2011年12月, EUROPEAN JOURNAL OF RADIOLOGY, 80(3) (3), E237 - E242, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2011年11月, EUROPEAN RADIOLOGY, 21(11) (11), 2336 - 2343, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- INTRODUCTION: Percutaneous transhepatic portal embolization is often performed to expand the indications for hepatic resection. Various etiologies of hepatic artery pseudoaneurysm have been reported, but regardless of the etiology, hepatic artery pseudoaneurysm is usually managed with an endovascular approach or open surgery, depending on the location and clinical symptomatology. However, it is difficult to manage hepatic artery pseudoaneurysm after percutaneous transhepatic portal embolization, since embolization of the hepatic artery may cause hepatic infarction CASE PRESENTATION: A 58-year-old Japanese man with hilar bile duct cancer underwent percutaneous transhepatic portal embolization to expand the indication for hepatic resection. Two days after percutaneous transhepatic portal embolization, our patient suddenly complained of abdominal pain. Contrast-enhanced computed tomography confirmed a pseudoaneurysm arising from a segmental branch of his right hepatic artery. Since embolization of the hepatic arterial branches may cause hepatic infarction, ultrasound-guided thrombin injection therapy was successfully performed for the pseudoaneurysm. CONCLUSION: We performed a thrombin injection instead of arterial embolization to avoid hepatic infarction. The rationale of this choice may be insufficient. However, ultrasound-guided percutaneous thrombin injection therapy may be considered as an alternative to percutaneous transarterial embolization or surgical intervention for an iatrogenic hepatic artery pseudoaneurysm.2011年10月, Journal of medical case reports, 5, 518 - 518, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2011年07月, WORLD JOURNAL OF SURGICAL ONCOLOGY, 9, 82 - 82, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (公社)日本医学放射線学会, 2011年02月, 日本医学放射線学会学術集会抄録集, 70回, S181 - S181, 日本語大腸癌肝転移の治療方針決定におけるGd-EOB-DTPA造影MRIの有用性[査読有り]
- (公社)日本医学放射線学会, 2011年02月, 日本医学放射線学会学術集会抄録集, 70回, S181 - S182, 日本語大腸癌肝転移における3T-MRIを用いたGd-EOB-DTPA造影MRIの診断能 手術症例での検討[査読有り]
- 2010年09月, EUROPEAN RADIOLOGY, 20(9) (9), 2265 - 2273, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)日本癌治療学会, 2010年09月, 日本癌治療学会誌, 45(2) (2), 471 - 471, 日本語がんの局所療法 がん緩和医療とIVR[査読有り]
- 「産婦人科の進歩」編集室, 2010年08月, 産婦人科の進歩, 62(3) (3), 299 - 299, 日本語
- 「産婦人科の進歩」編集室, 2009年11月, 産婦人科の進歩, 61(4) (4), 435 - 435, 日本語子宮がん診療における11C-コリンPET/CTの役割
- (公社)日本医学放射線学会, 2009年09月, 日本医学放射線学会秋季臨床大会抄録集, 45回, S442 - S442, 日本語IVRのエビデンスを求めて 血管系IVRのエビデンス 画像誘導下CV穿刺法のエビデンス
- (一社)日本癌治療学会, 2009年09月, 日本癌治療学会誌, 44(2) (2), 342 - 342, 日本語ガイドライン治療・臨床試験に該当しない症例に対する治療 IVRによる抗がん治療可能状況への導入[査読有り]
- 2009年05月, ANNALS OF NUCLEAR MEDICINE, 23(3) (3), 235 - 243, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- (公社)日本医学放射線学会, 2009年02月, 日本医学放射線学会学術集会抄録集, 68回, S136 - S136, 日本語CT,MRIを中心とした胆道系病変の画像診断
- 2008年05月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 32(3) (3), 415 - 417, 英語[査読有り]研究論文（学術雑誌）
- 2007年09月, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 34(9) (9), 1490 - 1497, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2007年05月, JOURNAL OF NUCLEAR MEDICINE, 48(5) (5), 704 - 711, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (公社)日本医学放射線学会, 2007年02月, 日本医学放射線学会学術集会抄録集, 66回, S105 - S105, 日本語脳統計学的画像診断法の発展とピットフォール
- (公社)日本医学放射線学会, 2007年02月, 日本医学放射線学会学術集会抄録集, 66回, S257 - S257, 日本語腎動脈狭窄に対する経皮的腎血管形成術 腎機能悪化予防についての検討
- 2005年, Japanese Journal of Clinical Radiology, 50(1) (1), 59 - 66, 日本語Endovascular therapy for type-B aortic dissection with aortic branch vessel compromise研究論文（学術雑誌）
- (一社)日本消化器外科学会, 2023年07月, 日本消化器外科学会総会, 78回, P070 - 3, 日本語肝細胞癌肉眼分類とアテゾリズマブ・ベバシズマブ併用療法の治療効果に関する検討
- (一社)日本肝臓学会, 2023年04月, 肝臓, 64(Suppl.1) (Suppl.1), A385 - A385, 日本語肝細胞癌肉眼分類とアテゾリズマブ・ベバシズマブ併用療法の治療効果に関する検討
- (一社)日本インターベンショナルラジオロジー学会, 2023年04月, 日本インターベンショナルラジオロジー学会雑誌, 38(Suppl.) (Suppl.), 140 - 140, 日本語有痛性脊椎転移に対する経皮的椎体形成術の有効性に関与する因子の検討
- (一財)日本消化器病学会, 2023年03月, 日本消化器病学会雑誌, 120(臨増総会) (臨増総会), A36 - A36, 日本語
- (公社)日本医学放射線学会, 2022年09月, 日本医学放射線学会秋季臨床大会抄録集, 59回, S308 - S308, 日本語脈管奇形・リンパ管の画像診断と治療戦略(診断) 画像診断から判断する脈管奇形の治療戦略 形成外科医の立場から
- (株)メディカルアイ, 2022年09月, Rad Fan, 20(11) (11), 22 - 25, 日本語【CTの現状と未来】(Part2)手の届く未来 Photon-counting detector CT DECTの原理・現状とPCD-CTに期待するもの
- (株)Gakken, 2022年09月, 画像診断, 42(11) (11), A96 - A97, 日本語
- (一社)日本インターベンショナルラジオロジー学会, 2022年08月, 日本インターベンショナルラジオロジー学会雑誌, 36(3) (3), 244 - 253, 日本語【Intermediate stage HCCに対するTACE】TACEにおける腫瘍微小環境の変化と分子標的薬・免疫治療併用の意義
- (株)医学出版, 2022年08月, 消化器内科, 4(8) (8), 63 - 68, 日本語【肝疾患における画像診断の進歩-腹部超音波、CT、MRI-】CTを用いたびまん性肝疾患の診断と定量評価の可能性
- (株)Gakken, 2022年03月, 画像診断, 42(4) (4), S106 - S119, 日本語
- (株)Gakken, 2022年03月, 画像診断, 42(4) (4), S184 - S195, 日本語
- (株)インナービジョン, 2022年03月, INNERVISION, 37(4) (4), 2 - 5, 日本語
- 日本画像医学会, 2022年02月, Japanese Journal of Diagnostic Imaging, 40(増刊) (増刊), 24 - 24, 日本語肝癌の画像診断 薬物療法に対する治療効果判定を含めて
- 医学図書出版(株), 2021年09月, 胆と膵, 42(9) (9), 815 - 822, 日本語
- 医学図書出版(株), 2021年09月, 胆と膵, 42(9) (9), 815 - 822, 日本語
- (公社)日本医学放射線学会, 2021年08月, 日本医学放射線学会秋季臨床大会抄録集, 57回, S339 - S339, 日本語Dual Energy CTの現在と展望 上腹部領域のDual Energy CT
- (株)アークメディア, 2021年08月, 肝胆膵, 83(2) (2), 209 - 218, 日本語【ここまできた肝細胞癌の薬物療法:2021 update】免疫療法の動向 WNT/β-catenin変異のimaging biomarkerとしてのEOB-MRI
- (一社)日本肝臓学会, 2021年05月, 肝臓, 62(5) (5), 229 - 239, 日本語
- (一社)日本肝臓学会, 2021年05月, 肝臓, 62(5) (5), 229 - 239, 日本語
- (株)メジカルビュー社, 2021年04月, 臨床画像, 37(4月増刊) (4月増刊), 128 - 150, 日本語
- (株)メジカルビュー社, 2021年04月, 臨床画像, 37(4) (4), 490 - 497, 日本語
- (株)メジカルビュー社, 2021年02月, 臨床画像, 37(2) (2), 230 - 244, 日本語
- Japan Society of Hepatology, 2021年, Acta Hepatologica Japonica, 62(5) (5), 229 - 239, 日本語書評論文,書評,文献紹介等
- 2021年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging, 22nd (CD-ROM)50歳代女性に生じ術前診断が困難であった卵巣卵黄嚢腫瘍の一例
- 2021年, 日本神経放射線学会プログラム・抄録集, 50th脊髄に発生したdiffuse midline glioma,H3K27M-mutantの3例
- (株)メジカルビュー社, 2021年01月, 臨床画像, 37(1) (1), 140 - 147, 日本語
- (公社)日本医師会, 2021年01月, 日本医師会雑誌, 149(10) (10), 1808 - 1809, 日本語CT or MRI CT、MRIどっちを依頼?(No.10) 肝 超音波検査で肝に腫瘤が疑われた
- (一社)日本消化器外科学会, 2020年12月, 日本消化器外科学会総会, 75回, RS15 - 7, 日本語肝機能不良・肝細胞癌症例に対するレンバチニブ治療成績の検討
- バイエル薬品(株), 2020年12月, 日独医報, 65(1) (1), 55 - 63, 日本語【マネジメントに苦慮する疾患:Is it benign,malignant or insignificant?】前立腺clinically insignificant cancerの診断とマネジメントにおけるMRIの役割
- (一社)日本インターベンショナルラジオロジー学会, 2020年11月, 日本インターベンショナルラジオロジー学会雑誌, 35(2) (2), 184 - 193, 日本語
- (株)学研メディカル秀潤社, 2020年10月, 画像診断, 40(13) (13), 1299 - 1310, 日本語
- (一社)日本インターベンショナルラジオロジー学会, 2020年08月, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 131 - 131, 日本語骨転移疼痛に対する集学的治療 -この痛みをどう治療するか- 骨転移に対する骨セメント治療 経皮的椎体形成術の適応を考える
- 金原出版(株), 2020年05月, 臨床放射線, 65(5) (5), 487 - 490, 日本語
- (株)インナービジョン, 2020年05月, Innervision, 35(5) (5), 14 - 16, 日本語
- (株)インナービジョン, 2020年03月, INNERVISION, 35(4) (4), 21 - 24, 日本語
- (公社)日本医学放射線学会, 2020年02月, Japanese Journal of Radiology, 38(Suppl.) (Suppl.), 38 - 38, 日本語子宮広間膜に発生した平滑筋肉腫の1例
- 日本放射線科専門医会・医会 = Japanese College of Radiology, 2020年, JCRニュース = JCR news : 日本放射線科専門医会・医会誌, (235) (235), 27 - 29, 日本語画像診断症例クイズ(Question 15)解答・解説
- 2020年, 日本神経放射線学会プログラム・抄録集, 49th胎児MRIの頭部画像を用いたディープラーニングによる胎児の週数予測
- 2020年, 核医学(Web), 57(Supplement) (Supplement)悪性腫瘍の全身FDG PET/MRIにおけるBSREMを用いた高速撮像と診断能の検討
- (一社)日本脈管学会, 2019年10月, 脈管学, 59(Suppl.) (Suppl.), S140 - S140, 日本語当院における脾動脈瘤に対する動脈塞栓術の治療成績
- (一社)日本脈管学会, 2019年10月, 脈管学, 59(Suppl.) (Suppl.), S175 - S175, 日本語Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績
- (公社)日本医学放射線学会, 2019年09月, 日本医学放射線学会秋季臨床大会抄録集, 55回, S436 - S436, 日本語肝炎症性腫瘤の画像診断
- (公社)日本医学放射線学会, 2019年09月, 日本医学放射線学会秋季臨床大会抄録集, 55回, S558 - S558, 日本語気管内挿管後に舌壊死を来した1例
- (一社)日本インターベンショナルラジオロジー学会, 2019年09月, 日本インターベンショナルラジオロジー学会雑誌, 34(1) (1), 79 - 79, 日本語直腸静脈瘤に対して上直腸静脈直接穿刺法で塞栓術を行った1例
- (公社)日本医学放射線学会, 2019年09月, 日本医学放射線学会秋季臨床大会抄録集, 55回, S558 - S558, 日本語気管内挿管後に舌壊死を来した1例
- (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 226 - 226, 日本語肝細胞癌に対する放射線照射治療後の経動脈的化学塞栓療法の安全性の検討
- (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 239 - 239, 日本語当院における経腟分娩後の産道出血に対する動脈塞栓術の検討
- (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 255 - 255, 日本語Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績
- (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 259 - 259, 日本語当院における大動脈解離に対するTEVARの治療成績
- (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 314 - 314, 日本語CTで認識できない骨病変に対するCTガイド下骨生検の検討
- (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 226 - 226, 日本語肝細胞癌に対する放射線照射治療後の経動脈的化学塞栓療法の安全性の検討
- (一社)日本インターベンショナルラジオロジー学会, 2019年04月, 日本インターベンショナルラジオロジー学会雑誌, 33(4) (4), 427 - 444, 日本語血管塞栓術に用いるNBCAのガイドライン2012
- (一社)日本インターベンショナルラジオロジー学会, 2019年04月, 日本インターベンショナルラジオロジー学会雑誌, 33(4) (4), 472 - 484, 日本語肝外傷に対するIVRのガイドライン2016
- 2019年, 脈管学(Web), 59(supplement) (supplement)当院における脾動脈瘤に対する動脈塞栓術の治療成績
- 2019年, 脈管学(Web), 59(supplement) (supplement)Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績
- 2019年, 日本インターベンショナルラジオロジー学会雑誌(Web), 34(1) (1)直腸静脈瘤に対して上直腸静脈直接穿刺法で塞栓術を行った1例
- 2019年, 泌尿器画像診断・治療技術研究会プログラム・抄録, 7th前立腺移行域癌診断におけるQuantitative Multiparametric MRIの有用性
- 2019年, 日本神経放射線学会プログラム・抄録集, 48th, 101, 日本語静脈洞血栓をきたしたRendu‐Osler‐Weber病の一例
- 2018年11月, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 33, 194 - 194, 英語Significance of pancreatic calcification on preoperative CT image of intraductal papillary mucinous neoplasm研究発表ペーパー・要旨（国際会議）
- (一社)日本インターベンショナルラジオロジー学会, 2018年11月, IVR: Interventional Radiology, 33(3) (3), 317 - 318, 日本語破裂性十二指腸静脈瘤に対してバルーン閉塞下逆行性静脈瘤塞栓術を施行した1例
- 金原出版(株), 2018年11月, 臨床放射線, 63(12) (12), 1582 - 1585, 日本語【救急IVR手技詳説 with WEB動画】手技詳説 非血管IVR 画像ガイド下穿刺 超音波ガイド下穿刺[招待有り]記事・総説・解説・論説等（学術雑誌）
- (一社)日本核医学会, 2018年11月, 核医学, 55(Suppl.) (Suppl.), S209 - S209, 英語FDG PET/MRにおける呼吸同期下MR吸収補正と画像再構成法の影響
- (一社)日本脈管学会, 2018年09月, 脈管学, 58(Suppl.) (Suppl.), S107 - S107, 日本語中長期成績からみた腹部大動脈瘤ステントグラフトの功罪 IMA閉塞例におけるEVAR後のType 2エンドリークの検討 予防的IMA塞栓術は有用か?
- (公社)日本医学放射線学会, 2018年09月, 日本医学放射線学会秋季臨床大会抄録集, 54回, S536 - S536, 日本語翼口蓋窩に生じた筋上皮腫の1例
- (一社)神緑会, 2018年08月, 神緑会学術誌, 34, 38 - 40, 日本語Dual-energy CTを用いた薬剤溶出性ビーズ内の抗がん剤濃度定量についての基礎的研究
- (一社)日本門脈圧亢進症学会, 2018年08月, 日本門脈圧亢進症学会雑誌, 24(3) (3), 86 - 86, 日本語IVRの進歩がどのように門脈圧亢進症の治療を変えたのか? 肝細胞癌門脈腫瘍栓に対するEMS留置術
- 日本画像医学会, 2018年02月, Japanese Journal of Diagnostic Imaging, 36(1) (1), 58 - 58, 日本語肝細胞癌の画像診断
- 2018年, 脈管学(Web), 58(supplement) (supplement)IMA閉塞例におけるEVAR後のType2エンドリークの検討:予防的IMA塞栓術は有用か?
- 2017年11月, NAGOYA JOURNAL OF MEDICAL SCIENCE, 79(4) (4), 527 - 543, 英語書評論文,書評,文献紹介等
- 医学図書出版, 2017年10月, 肝臓クリニカルアップデート, 3(2) (2), 115 - 120, 日本語肝癌画像診断のアップデート : CT, MRI (特集 肝癌診療A to Z)[招待有り]記事・総説・解説・論説等（学術雑誌）
- (一社)日本核医学会, 2017年09月, 核医学, 54(Suppl.) (Suppl.), S193 - S193, 日本語F-18 FDG PET/MRを用いた消化管の生理的集積に関する検討 FDG集積とMRI信号との対比
- 2017年07月, Metallic Stentの現状と進歩XVII, 32, 20 - 21, 日本語空腸動脈瘤の塞栓術後に正中弓状靭帯の圧迫による副駆動脈起始部狭窄に対してステントを留置した1例[招待有り]速報，短報，研究ノート等（学術雑誌）
- 2017年05月, JOURNAL OF NUCLEAR MEDICINE, 58, 英語Integrated FDG-PET/MRI for whole-body staging in patients with recurrent gynecological cancer研究発表ペーパー・要旨（国際会議）
- 金原出版(株), 2017年04月, 臨床放射線, 62(4) (4), 497 - 505, 日本語[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (一社)日本インターベンショナルラジオロジー学会, 2017年04月, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 129 - 129, 日本語IVR技術のいろは 超音波ガイド下穿刺技術のいろは
- (一社)日本インターベンショナルラジオロジー学会, 2017年04月, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 164 - 164, 日本語腫瘍性脊椎圧骨折に対する経皮的椎体形成術の検討
- (一社)日本インターベンショナルラジオロジー学会, 2017年04月, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 180 - 180, 日本語動脈塞栓術を施行した腎部分切除術後の仮性動脈瘤の検討
- (一社)日本インターベンショナルラジオロジー学会, 2017年04月, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 236 - 236, 日本語十二指腸静脈瘤に対するB-RTOの有効性の検討
- 金原出版(株), 2016年11月, 臨床放射線, 61(11) (11), 1439 - 1443, 日本語[査読有り]記事・総説・解説・論説等（学術雑誌）
- 2016年10月, EUROPEAN RADIOLOGY, 26(10) (10), 3677 - 3690, 英語, 国際誌[査読有り]
- (一社)日本脈管学会, 2016年10月, 脈管学, 56(Suppl.) (Suppl.), S137 - S137, 日本語EVAR後の遅発性type 1bエンドリークの危険因子に関する検討
- (一社)日本脈管学会, 2016年10月, 脈管学, 56(Suppl.) (Suppl.), S188 - S189, 日本語左総腸骨動脈閉塞を伴う腹部大動脈瘤に対するEVAR後にTypell endoleak塞栓を繰り返した1例
- (一社)日本脈管学会, 2016年10月, 脈管学, 56(Suppl.) (Suppl.), S207 - S207, 日本語上腸間膜動脈急性閉塞に対しフォガティースルールーメンカテーテルを用いて血栓除去を行った一例
- (一社)日本インターベンショナルラジオロジー学会, 2016年08月, IVR: Interventional Radiology, 31(3) (3), 266 - 266, 日本語ハイブリッド手術システムを用いたIVR 非大血管疾患における臨床応用
- (一社)日本インターベンショナルラジオロジー学会, 2016年08月, IVR: Interventional Radiology, 31(3) (3), 267 - 267, 日本語左総腸骨動脈閉塞を伴う腹部大動脈瘤に対するEVAR後にType II endoleak塞栓を繰り返した1例
- (一社)日本インターベンショナルラジオロジー学会, 2016年06月, IVR: Interventional Radiology, 31(2) (2), 129 - 135, 日本語[査読有り][招待有り]記事・総説・解説・論説等（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2016年06月, IVR: Interventional Radiology, 31(2) (2), 178 - 178, 日本語予防的IMA塞栓術を施行したENDURANT Stentgraft Systemを用いたEVARの治療成績
- (一社)日本インターベンショナルラジオロジー学会, 2016年06月, IVR: Interventional Radiology, 31(2) (2), 178 - 178, 日本語EVAR後の遅発性Type 1a endoleakに対し瘤内塞栓術およびAortic cuff留置術にて治療した1例
- (一社)日本インターベンショナルラジオロジー学会, 2016年06月, IVR: Interventional Radiology, 31(2) (2), 189 - 189, 日本語大動脈・末梢動脈疾患に対する救急IVR 神戸大学病院における取り組みとその応用
- (一社)日本インターベンショナルラジオロジー学会, 2016年06月, IVR: Interventional Radiology, 31(2) (2), 182 - 182, 日本語TAEとデノスマブ投与の併用が奏功した仙骨巨細胞腫の1例
- (株)インナービジョン, 2016年04月, INNERVISION, 31(5号) (5号), 60 - 61, 日本語[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (株)インナービジョン, 2016年04月, INNERVISION, 31(5号) (5号), 2 - 5, 日本語[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (株)メジカルビュー社, 2016年04月, 臨床画像, 32(4月増刊) (4月増刊), 186 - 195, 日本語【これだけは知っておきたいCT/MRIの基本:研修医の必須知識】腫瘍性病変 肝・胆・膵[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (一社)日本インターベンショナルラジオロジー学会, 2016年04月, IVR: Interventional Radiology, 31(Suppl.) (Suppl.), 113 - 113, 日本語ビーズ導入後のTACEの現状 多発肝細胞癌に対する非選択的DEB-TACEの有用性の検討
- (一社)日本インターベンショナルラジオロジー学会, 2016年04月, IVR: Interventional Radiology, 31(Suppl.) (Suppl.), 174 - 174, 日本語ブタ肝後面下大静脈損傷モデルを用いたステントグラフトによる止血効果の検討
- 2016年, 脈管学(Web), 56(supplement) (supplement), S188‐S189(J‐STAGE), 日本語左総腸骨動脈閉塞を伴う腹部大動脈瘤に対するEVAR後にTypeII endoleak塞栓を繰り返した1例
- 2016年, 脈管学(Web), 56(supplement) (supplement), S137(J‐STAGE), 日本語EVAR後の遅発性type1bエンドリークの危険因子に関する検討
- 2016年, 脈管学(Web), 56(supplement) (supplement), S207(J‐STAGE), 日本語上腸間膜動脈急性閉塞に対しフォガティースルールーメンカテーテルを用いて血栓除去を行った一例
- (一社)日本インターベンショナルラジオロジー学会, 2015年09月, IVR: Interventional Radiology, 30(3) (3), 275 - 275, 日本語当院における薬剤溶出性球状塞栓物質を用いたTACE(DEB-TACE)の初期治療成績
- (一社)日本インターベンショナルラジオロジー学会, 2015年06月, IVR: Interventional Radiology, 30(2) (2), 166 - 171, 日本語[査読有り]記事・総説・解説・論説等（学術雑誌）
- 2014年10月, CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 37(5) (5), 1405 - 1406, 英語, 国際誌[査読有り]
- 2014年08月, JAPANESE JOURNAL OF RADIOLOGY, 32(8) (8), 500 - 517, 英語, 国内誌[査読有り]
- 産業開発機構(株), 2014年08月, 映像情報Medical, 46(8) (8), 732 - 737, 日本語【腹部Interventional Radiologyの手技とコツ】腹部外傷に対するIVR[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (一社)日本インターベンショナルラジオロジー学会, 2014年08月, IVR: Interventional Radiology, 29(3) (3), 252 - 257, 日本語【NBCA塞栓術の現状と病理組織学的影響】NBCA塞栓術の現状と病理組織学的影響 膵臓[招待有り]記事・総説・解説・論説等（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2014年06月, IVR: Interventional Radiology, 29(2) (2), 219 - 219, 日本語巨細胞動脈炎の関与が疑われる両側上腕動脈病変に対しPTAを施行した2例
- (一社)日本インターベンショナルラジオロジー学会, 2014年06月, IVR: Interventional Radiology, 29(2) (2), 223 - 223, 日本語当院における非外傷性特発性後腹膜出血に対する動脈塞栓術の検討
- (一社)日本インターベンショナルラジオロジー学会, 2014年06月, IVR: Interventional Radiology, 29(2) (2), 188 - 194, 日本語外傷IVRの基本と応用 脾損傷[招待有り]記事・総説・解説・論説等（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2014年06月, IVR: Interventional Radiology, 29(2) (2), 140 - 146, 日本語【非外傷性出血のIVR】非外傷性の特発性後腹膜出血[招待有り]記事・総説・解説・論説等（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2014年05月, IVR: Interventional Radiology, 29(Suppl.) (Suppl.), 153 - 153, 日本語周産期出血に対する子宮動脈塞栓術における子宮動脈造影所見の検討
- (一社)日本インターベンショナルラジオロジー学会, 2014年05月, IVR: Interventional Radiology, 29(Suppl.) (Suppl.), 176 - 176, 日本語鈍的胸部大動脈損傷に対する企業性ステントグラフトを用いたTEVARの現状
- (一社)日本インターベンショナルラジオロジー学会, 2014年05月, IVR: Interventional Radiology, 29(Suppl.) (Suppl.), 194 - 194, 日本語急性下肢動脈閉塞に対するFogarty Thru-Lumen catheterを用いた選択的血栓除去術の治療成績の検討
- (一社)日本インターベンショナルラジオロジー学会, 2014年05月, IVR: Interventional Radiology, 29(Suppl.) (Suppl.), 204 - 204, 日本語EVAR後Type II Endoleak残存症例に対する追加治療の成績
- (一社)日本インターベンショナルラジオロジー学会, 2014年02月, IVR: Interventional Radiology, 29(1) (1), 34 - 42, 日本語【救急疾患に対するIVR】泌尿器科領域の救急疾患に対するIVR[招待有り]記事・総説・解説・論説等（学術雑誌）
- (株)へるす出版, 2013年09月, 救急医学, 37(10号) (10号), 1382 - 1386, 日本語【救急診療におけるCT・MRIとIVR】 IVR 上腸間膜動脈血栓塞栓症[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (一社)日本インターベンショナルラジオロジー学会, 2013年04月, IVR: Interventional Radiology, 28(Suppl.) (Suppl.), 103 - 103, 日本語内臓動脈瘤に対するIVR 孤立性内腸骨動脈瘤に対する血管内治療の長期成績
- (一社)日本インターベンショナルラジオロジー学会, 2013年04月, IVR: Interventional Radiology, 28(Suppl.) (Suppl.), 105 - 105, 日本語出血に対するIVR 非外傷性特発性後腹膜出血に対する動脈塞栓術の検討
- (一社)日本インターベンショナルラジオロジー学会, 2013年04月, IVR: Interventional Radiology, 28(Suppl.) (Suppl.), 173 - 173, 日本語当院における危機的産科出血に対する子宮動脈塞栓術の治療成績
- (株)羊土社, 2013年02月, レジデントノート, 14(17号) (17号), 3259 - 3264, 日本語【外科の基本 手術前後の患者さんを診る 手術の流れや手技、周術期管理が身につき、外科がわかる、好きになる】 (第2章)外科研修で覚えたい手技 CVポートの入れ方、管理のしかた[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- メディカ出版, 2012年04月, プロフェッショナルがんナーシング, 2(2) (2), 141 - 144, 日本語腹腔-静脈シャント造設術 (緩和ケア特集 イラストでわかる! 胸水・腹水の治療と看護をとことん理解する)[査読有り][招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 克誠堂出版, 2012年02月, 日本胸部臨床, 71(2) (2), 155 - 162, 日本語胸部領域における血管系インターベンションによる合併症 (特集 呼吸器検査法におけるハザード)[査読有り][招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- メディカルレビュー社, 2011年12月, 大腸癌frontier, 4(4) (4), 401 - 404, 日本語Q&Aで綴る レジデント・ノート : 専門医がわかりやすく解説(No.30)中心静脈ポートについて,留置手技のコツ,合併症の予 防・対処法などの管理のコツを教えて下さい。[査読有り][招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (株)アークメディア, 2010年10月, 肝胆膵, 61(4) (4), 653 - 661, 日本語【エキスパートに学ぶIVRのテクニック、適応、合併症】膵臓:膵管ステント 十二指腸狭窄に対するステント記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (一社)日本インターベンショナルラジオロジー学会, 2010年10月, IVR: Interventional Radiology, 25(4) (4), 427 - 434, 日本語【ダイナミック局所解剖】大静脈とアクセスの解剖学的考察
- 金原出版(株), 2010年05月, 臨床放射線, 55(5) (5), 621 - 626, 日本語【IVRのエビデンスを求めて】画像誘導下CV穿刺法のエビデンス記事・総説・解説・論説等（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2010年04月, IVR: Interventional Radiology, 25(2号) (2号), 137 - 143, 日本語記事・総説・解説・論説等（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2010年04月, IVR: Interventional Radiology, 25(2) (2), 211 - 216, 日本語IVRと超音波検査 エコーガイド下中心静脈穿刺法の技術[査読有り][招待有り]記事・総説・解説・論説等（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2010年01月, IVR: Interventional Radiology, 25(1) (1), 10 - 16, 日本語[査読有り][招待有り]記事・総説・解説・論説等（学術雑誌）
- (NPO)日本乳癌検診学会, 2009年10月, 日本乳癌検診学会誌, 18(3) (3), 358 - 358, 日本語
- (公社)日本医学放射線学会, 2009年02月, 日本医学放射線学会学術集会抄録集, 68回, S346 - S346, 日本語慢性腎障害(CKD)症例における肝臓dynamic CTでの造影剤減量プロトコールの検討
- (一社)日本インターベンショナルラジオロジー学会, 2009年01月, IVR: Interventional Radiology, 24(Suppl.) (Suppl.), 42 - 44, 日本語インフォームドコンセント(気道、静脈) 大静脈ステントのインフォームドコンセント
- 2009年, 日本医学放射線学会秋季臨床大会抄録集, 45th血管系IVRのエビデンス 1-4 画像誘導下CV穿刺法のエビデンス
- (株)インナービジョン, 2008年07月, INNERVISION, 23(8号) (8号), 73 - 79, 日本語[査読有り][招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (株)先端医学社, 2008年04月, 緩和医療学, 10(2) (2), 177 - 185, 日本語
- (公社)日本医学放射線学会, 2008年04月, Radiation Medicine, 26(Suppl.I) (Suppl.I), 47 - 47, 日本語乳癌放射線治療後に慢性好酸球性肺炎(CEP)を発症した1例
- (公社)日本医学放射線学会, 2008年02月, 日本医学放射線学会学術集会抄録集, 67回, S145 - S146, 日本語肝dynamic CTにおける注入時間一定法を用いたヨード造影剤減量プロトコールの検討
- (株)先端医学社, 2007年10月, 緩和医療学, 9(4) (4), 336 - 347, 日本語
- (一社)日本インターベンショナルラジオロジー学会, 2007年10月, IVR: Interventional Radiology, 22(4) (4), 498 - 498, 日本語経皮的頸部食道穿刺法を用いたイレウスチューブのルート変更術
- 一般社団法人 日本放射線腫瘍学会, 2007年06月25日, The Journal of JASTRO = 日本放射線腫瘍学会誌, 19(2) (2), 109 - 116, 日本語[査読有り]記事・総説・解説・論説等（学術雑誌）
- バイエル薬品(株), 2007年05月, 日独医報, 52(1) (1), 129 - 129, 日本語当院にて経験したPopliteal Artery Entrapment Syndrome
- (公社)日本医学放射線学会, 2007年04月, Radiation Medicine, 25(Suppl.I) (Suppl.I), 64 - 64, 日本語縊頸を機に発症したreversible posterior leukoencephalopathy syndromeの一例
- (一社)日本インターベンショナルラジオロジー学会, 2007年04月, IVR: Interventional Radiology, 22(2) (2), 267 - 267, 日本語急性腎不全を来したI型大動脈解離による腎動脈狭窄に対してstentを留置した1例
- (一社)日本核医学会, 2006年11月, 核医学, 43(4) (4), 367 - 367, 日本語
- (一社)日本核医学会, 2006年10月, 核医学, 43(3) (3), 242 - 243, 日本語軽症レビー小体型認知症とアルツハイマー病のFDG-PET全自動コンピューター補助診断
- 2006年09月, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 33, S295 - S295, 英語Comparison of morphologic and metabolic reduction in mild dementia with Lewy bodies and Alzheimer disease研究発表ペーパー・要旨（国際会議）
- (公社)日本医学放射線学会, 2006年09月, 日本医学放射線学会秋季臨床大会抄録集, 42回, S518 - S518, 日本語特発性脊椎硬膜外血腫の2例
- (一社)日本脈管学会, 2006年09月, 脈管学, 46(Suppl.) (Suppl.), S204 - S204, 日本語TASCB・C型腸骨動脈病変に対する血管内治療とbypass術の比較
- (株)メジカルビュー社, 2006年07月, 臨床画像, 22(7) (7), 791 - 799, 日本語【肺血栓塞栓症に必要な画像診断およびIVR】肺血栓塞栓症と深部静脈血栓症のIVR治療[査読有り][招待有り]記事・総説・解説・論説等（学術雑誌）
- (一社)日本インターベンショナルラジオロジー学会, 2006年04月, IVR: Interventional Radiology, 21(2) (2), 213 - 214, 日本語透析シャント不全に対するカッティングバルーンの初期使用経験
- (一社)日本インターベンショナルラジオロジー学会, 2006年04月, IVR: Interventional Radiology, 21(2) (2), 219 - 219, 日本語Wallstent留置にて治療した鈍的骨盤外傷による腸骨静脈損傷の1例
- (公社)日本医学放射線学会, 2006年02月, 日本医学放射線学会学術集会抄録集, 65回, S255 - S255, 日本語鈍的骨盤外傷に伴う腸骨静脈損傷症例の画像診断
- (公社)日本医学放射線学会, 2006年02月, 日本医学放射線学会学術集会抄録集, 65回, S331 - S331, 日本語透析シャント不全に対するカッティングバルーンの初期成績
- (一財)日本消化器病学会, 2005年09月, 日本消化器病学会雑誌, 102(臨増大会) (臨増大会), A779 - A779, 日本語大腸憩室出血におけるair enema併用造影dynamic CTの有用性
- (一財)日本消化器病学会, 2005年09月, 日本消化器病学会雑誌, 102(臨増大会) (臨増大会), A704 - A704, 日本語開院後1年6ヵ月の期間に経験した食道表在癌の検討
- (一社)日本インターベンショナルラジオロジー学会, 2005年07月, IVR: Interventional Radiology, 20(3) (3), 330 - 330, 日本語透析シャント不全に対するカッティングバルーンの初期使用経験
- (一社)日本インターベンショナルラジオロジー学会, 2005年02月, IVR: Interventional Radiology, 20(2) (2), 212 - 212, 日本語経カテーテル的動脈塞栓術が奏功した腰動脈鋭的損傷の2例
- (一社)日本インターベンショナルラジオロジー学会, 2005年02月, IVR: Interventional Radiology, 20(2) (2), 215 - 216, 日本語大動脈解離に対する血管ステントの応用
- (一社)日本インターベンショナルラジオロジー学会, 2005年02月, IVR: Interventional Radiology, 20(2) (2), 216 - 216, 日本語ステントグラフト留置が有用であった分枝虚血障害合併B型大動脈解離の1例
- 金原出版(株), 2005年01月, 臨床放射線, 50(1) (1), 59 - 66, 日本語分枝虚血合併B型大動脈解離に対する血管内治療 特にステント留置,経皮的開窓術を用いて治療した自験例を中心に記事・総説・解説・論説等（学術雑誌）
- (公社)日本医学放射線学会, 2004年09月, 日本医学放射線学会雑誌, 64(6) (6), S414 - S414, 日本語air enema併用造影dynamic CTによる大腸憩室出血の描出能 IVR術前評価における有用性について
- (公社)日本医学放射線学会, 2004年03月, 日本医学放射線学会雑誌, 64(3) (3), 168 - 168, 日本語腎被膜由来の悪性線維性組織球腫の一例
- (公社)日本医学放射線学会, 2004年01月, 日本医学放射線学会雑誌, 64(1) (1), 68 - 68, 日本語側頭筋に発生した限局性筋炎の一例
- (一社)日本核医学会, 2003年05月, 核医学, 40(2) (2), 232 - 233, 日本語
- (公社)日本医学放射線学会, 2003年02月, 日本医学放射線学会雑誌, 63(3) (3), 114 - 114, 日本語脊柱管内を5椎体にわたり長軸方向に発育した上衣腫の1例
- 共著, II章 A.検査 7画像診断, 南江堂, 2020年11月, 120-150, 日本語肝臓専門医テキスト改訂第3版教科書・概説・概論
- 共著, 第5章 肝癌の診断 B画像診断 1.総論, 医学書院, 2020年04月, 53-56, 日本語肝癌診療マニュアル第4版学術書
- 分担執筆, Ⅱ疾患編 3消化器疾患 肝良性腫瘍, 医学書院, 2020年03月, 783-786, 日本語, 良性肝腫瘍の診断に重要な点を解説今日の診断指針 第8版学術書
- 分担執筆, 第6章 肝動脈（化学）塞栓療法TA(C)E, 金原出版, 2020年02月, 159-184, 日本語, ISBN: 4307204093肝癌診療ガイドライン 2017年版補訂版学術書
- 分担執筆, [Part IV Abdomen: Cirrhotic Liver.], Springer, 2019年, 447-489, 英語Multislice CT Fourth Edition.教科書・概説・概論
- その他, 日本臨床, 2018年, 日本語特集：肝癌-診断・治療の最新知見- / II. 肝癌の診断 ダイナミックCT・MRI学術書
- その他, 中山書店, 2017年, 日本語プリンシプル消化器疾患の臨床 3.ここまできた肝臓病診療 / II章：検査・診断 画像検査 –血管造影-学術書
- その他, 中山書店, 2017年, 日本語プリンシプル消化器疾患の臨床 3.ここまできた肝臓病診療 / II章：検査・診断 画像検査 -CT-学術書
- その他, 金原出版, 2016年04月, 日本語画像診断ガイドライン2016年度版 / 【CQ90 急性胆嚢炎が疑われた場合、行うべき画像検査は何か？】学術書
- メジカルビュー社, 2016年03月Key所見から読む肝胆膵の画像診断 MRI T1強調像 高信号結節
- メジカルビュー社, 2016年03月Key所見から読む肝胆膵の画像診断 MRI T1強調像 肝実質の低信号
- メジカルビュー社, 2016年03月Key所見から読む肝胆膵の画像診断 MRI T1強調像 肝実質の高信号
- その他, 羊土社, 2013年, 日本語動画で身につく肝疾患の基本手技 -インターベンション治療の秘訣- / 第3章2-2 全身化学療法のためのCVポート留置術学術書
- その他, 金原出版, 2013年, 日本語画像診断ガイドライン2013年度版 / CQ79 急性胆嚢炎が疑われた場合行われる画像検査は何か？学術書
- 共著, CQ9 他の塞栓物質との併用は有用か？, 一般社団法人 日本IVR学会編, 2012年血管塞栓術に用いるNBCAのガイドライン
- 第56回日本医学放射線学会秋季臨床大会20, 2020年10月, 日本語腹部領域での画像診断～おさえておくべきポイント～ 臨床に役立つ肝細胞癌の画像診断[招待有り]公開講演，セミナー，チュートリアル，講習，講義等
- 第48回日本磁気共鳴医学会大会, 2020年09月, 日本語, 日本磁気共鳴医学会, web開催, 国内会議肝の最新MRI びまん性肝疾患における定量MRIの臨床応用[招待有り]シンポジウム・ワークショップパネル（指名）
- 第79回日本医学放射線学会総会, 2020年05月, 日本語, 日本医学放射線学会, Web開催, 国内会議肝胆膵の画像診断 肝切除後肝不全の予測における画像診断の有用性[招待有り]公開講演，セミナー，チュートリアル，講習，講義等
- 第79回日本医学放射線学会総会, 2020年05月, 日本語, 日本医学放射線学会, Web開催, 国内会議腹部造影CTの最前線 肝細胞癌に対する薬物療法と画像診断[招待有り]公開講演，セミナー，チュートリアル，講習，講義等
- 第43回日本肝臓学会西部会, 2019年12月, 日本語, 日本肝臓学会, 下関, 日本国, 国内会議肝臓学源平合戦 ～Pros and Cons～シンポジウム・ワークショップパネル（指名）
- 105th Radiological Society of North America, Scientific Assembly and Annual Meeting., 2019年12月, 英語, Radiological Society of North America, Chicago, アメリカ合衆国, 国際会議Development and Assessment of Respiratory Motion-Resolved Hepatobiliary Phase Cine-MRI using Compressed SENSE for Stereotactic Body Radiotherapy in Liver Tumor.口頭発表（一般）
- 105th Radiological Society of North America, Scientific Assembly and Annual Meeting., 2019年12月, 英語, Radiological Society of North America, Chicago, アメリカ合衆国, 国際会議Utility of Extracellular Volume Fraction Measured from Multiphasic Contrast-Enhanced Computed Tomography for the Estimation of Pancreatic Fibrosis.ポスター発表
- 第55回 日本医学放射線学会 秋季臨床大会, 2019年10月, 日本語, 日本医学放射線学会, 名古屋, 日本国, 国内会議肝腫瘤性病変の画像診断：肝炎症性腫瘤の画像診断公開講演，セミナー，チュートリアル，講習，講義等
- 第47回 日本磁気共鳴医学会大会, 2019年09月, 日本語, 日本磁気共鳴医学会, 熊本, 日本国, 国内会議肝画像診断における最新MRI技術の臨床的意義：転移性肝癌の診断公開講演，セミナー，チュートリアル，講習，講義等
- The 10th Asia-Pacific Primary Liver Cancer Expert Meeting, 2019年08月, 英語, APPLE, 札幌, 日本国, 国際会議Dual-Energy CT Applications in the Liver[招待有り]公開講演，セミナー，チュートリアル，講習，講義等
- 第3回西新宿Radiology Forum, 2019年08月, 日本語, 東京, 日本国, 国内会議Dual-Energy CTを用いた上腹部画像診断公開講演，セミナー，チュートリアル，講習，講義等
- Advanced Medical Imaging研究会2019, 2019年07月, 日本語, Advanced Medical Imaging研究会, 大阪, 日本国, 国内会議各領域の進歩3：肝臓シンポジウム・ワークショップパネル（指名）
- Advanced Medical Imaging研究会2019, 2019年07月, 日本語, Advanced Medical Imaging研究会, 大阪, 日本国, 国内会議肝細胞癌に対する分子標的療法における画像的効果判定公開講演，セミナー，チュートリアル，講習，講義等
- JRCミッドサマーセミナー2019, 2019年07月, 日本語, 日本放射線医会, 神戸, 日本国, 国内会議肝転移における肝特異性造影MRIの意義公開講演，セミナー，チュートリアル，講習，講義等
- 第29回 関西肝血流動態・機能イメージ研究会, 2019年07月, 日本語, 肝血流動態・機能イメージ研究会, 大阪, 日本国, 国内会議LI-RADS CT・MRI公開講演，セミナー，チュートリアル，講習，講義等
- 第33回 日本腹部放射線学会, 2019年06月, 日本語, 日本腹部放射線学会, 下関, 日本国, 国内会議腹部領域の画像診断 おさえておくべきポイント 造影CTを用いた上腹部臓器の線維化定量公開講演，セミナー，チュートリアル，講習，講義等
- 第2回天王寺若手肝疾患カンファレンス, 2019年06月, 日本語, 大阪, 日本国, 国内会議肝細胞癌に対する分子標的療法における画像的効果判定公開講演，セミナー，チュートリアル，講習，講義等
- ISMRM 27th Annual Meeting and Exhibition, 2019年05月, 英語, ISMRM, モントリオール, カナダ, 国際会議Diverse Perspectives on Imaging-Based Diagnosis of HCC -Asian Guidelines-公開講演，セミナー，チュートリアル，講習，講義等
- 104th Radiological Society of North America, Scientific Assembly and Annual Meeting., 2018年11月, 英語, 国際会議Utility of Extracellular Volume Fraction Measured from Multiphasic Contrast-Enhanced Computed Tomography for the Estimation of Pancreatic Fibrosis.ポスター発表
- The 58th Annual Scientific Meeting of the Japanese Society of Nuclear Medicine, 2018年11月, 英語, Japanese Society of Nuclear Medicine (JSNM), Okinawa, 国内会議Impact of respiratory-gated MR attenuation correction and PET reconstruction algorithm on FDG PET/MR口頭発表（一般）
- 兵庫県IVR懇話会, 2018年11月, 日本語, 富士製薬工業株式会社, 神戸, 国内会議当院における経腟分娩後の産道出血に対する動脈塞栓術の検討口頭発表（一般）
- The 104th Scientific Assembly and Annual Meeting of the Radiological Society of North America, 2018年11月, 英語, Chicago, 国際会議New and Updated Topics in Targeted Therapies for the Treatment of Advanced and Metastatic Renal Cell Carcinoma: What Radiologists Should Knowポスター発表
- 第54回日本医学放射線学会秋季臨床大会（第31回頭頸部放射線研究会）, 2018年10月, 日本語, 福岡, 国内会議翼口蓋窩に生じた筋上皮腫の1例口頭発表（一般）
- 3rd Asia Pacific Liver Imaging Symposium (APLIS 2018), 2018年10月, 英語, Bayer, Shanghai, 国際会議Secondary Liver Cancer - Radiologist's perspective - detecting small liver metastasis (primary colorectal carcinoma)シンポジウム・ワークショップパネル（指名）
- 第51回兵庫県磁気共鳴医学研究会, 2018年07月, 日本語, 神戸, 国内会議Retinal Vasculopathy with Cerebral leukoencephalopathy (RVCL) の一例口頭発表（一般）
- 第65回関西IVR研究会, 2018年06月, 日本語, 大阪, 国内会議破裂性十二指腸静脈瘤に対してバルーン閉塞下逆行性静脈瘤塞栓術を施行した一例口頭発表（一般）
- 第6回金沢兼六画像診断研究会, 2018年06月, 日本語, 国内会議(教育講演) 肝細胞癌に対する画像診断ガイドラインと分子標的療法の現状口頭発表（一般）
- 第32回日本腹部放射線学会, 2018年05月, 日本語, 鎌倉, 国内会議術前診断が困難であった副腎血管肉腫の1例口頭発表（一般）
- The Joint Meeting of the 47th Meeting of the Japanese Society of Interventional Radiology & The 13th Meeting of the International Symposium of Interventional Radiology, 2018年05月, 英語, Tokyo, 国際会議Embolization for acute hemorrhage in patients with head and neck cancer口頭発表（一般）
- The Joint Meeting of the 47th Meeting of the Japanese Society of Interventional Radiology & The 13th Meeting of the International Symposium of Interventional Radiology, 2018年05月, 英語, 国際会議The feasibility of preoperative embolization for partial resection of hypervascular spinal tumor口頭発表（一般）
- The Joint Meeting of the 47th Meeting of the Japanese Society of Interventional Radiology & The 13th Meeting of the International Symposium of Interventional Radiology, 2018年05月, 英語, 国際会議Embolization with NBCA for acute bleeding from pancreatic and peripancreatic arteries口頭発表（一般）
- The 5th Yeungnam-Kasai HBP Surgeons Joint Meeting 2018, 2018年03月, 英語, 和歌山県立医科大学, Daegu, Korea, 国際会議Histological and molecular characterization of intrahepatic bile duct cancers suggests an expanded definition of perihilar cholangiocarcinoma[招待有り]ポスター発表
- 第319回日本医学放射線学会関西地方会, 2018年02月, 日本語, 大阪, 国内会議線維軟骨塞栓症が疑われた若年者脊髄梗塞の一例口頭発表（一般）
- 第318回日本医学放射線学会関西地方会, 2018年02月, 英語, 大阪, 国内会議子宮広間膜に発生した平滑筋肉種の一例口頭発表（一般）
- 第390回日本医学放射線学会関西地方会, 2018年02月, 日本語, 日本医学放射線学会, 大阪, 国内会議子宮広間膜に発生した平滑筋肉腫の一例[招待有り]口頭発表（一般）
- 104th Radiological Society of North America, Scientific Assembly and Annual Meeting., 2017年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Quantification of Cisplatin Concentration by using Material Decomposition Algorithm at 3rd Generation Dual Source Dual-Energy CT -An Experimental Phantom Study-.[招待有り]口頭発表（一般）
- 103th Radiological Society of North America, Scientific Assembly and Annual Meeting., 2017年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Dual-Energy CT for Noninvasive Staging of Liver Fibrosis: Accuracy of Iodine Density Measurements from Contrast-Enhanced Data.[招待有り]ポスター発表
- 第103回北米放射線学会, 2017年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Comparison of Integrated 18F-FDG PET/MRI Without Contrast Agents and Dynamic Contrast-enhanced MRI in Evaluating FIGO Stage in Uterine Cancer: A Preliminary Study[招待有り]ポスター発表
- 105th Radiological Society of North America, Scientific Assembly and Annual Meeting., 2017年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Clinical Significance of FDG PET in Combination with International Consensus Guidelines 2012 for the Management of Intraductal Papillary Mucinous Neoplasms of the Pancreas.[招待有り]ポスター発表
- 第57回日本核医学会総会, 2017年10月, 英語, 日本核医学会, 横浜, 【目的】PET/MR一体型装置を用いて消化管の生理的なFDG集積を評価し，MRI信号との関連を検討する【方法】消化管疾患を伴わない80例を対象に後方視的に検討した．PET収集とともに，全身MRIの横断像撮像を行った．消化管は手動で抽出され，次に2 point DIXON法の脂肪画像上で閾値を用い消化管周囲の脂肪織を除外した．得られた関心領域は複写され，閾値を用いて，T1 /T2強調画像での信号の組み合わせから4領域に分割した．各関心領域は同時収集されたPET画像上に複写され，平均SUVを測定した． 【結果】T1/T2強調画像で高/低信号を呈する領域で，下行結腸の集積(1.0±0.3)が上部消化管と比して有意に低値であった(p<0.0001)． T1/T2強調画像で低/高信号を呈する領域では，回腸の集積(2.2±0.6)が他と比して有意に高値であった(, 国内会議F-18 FDG PET/MRを用いた消化管の生理的集積に関する検討：FDG集積とMRI信号との対比[招待有り]口頭発表（一般）
- CIRSE (Cardiovascular and Interventional Radiological Society of Europe) Annual Scientific Meeting, 2017年09月, 英語, CIRSE, Copenhagen, Denmark, 国際会議Balloon-occluded retrograde transvenous obliteration for duodenal varices.[招待有り]ポスター発表
- 第2回Advanced Medical Imaging研究会, 2017年07月, 日本語, Society of Advanced Medical Imaging, 大阪, 国内会議Dual-Energy CTから得られたヨード密度画像を用いた肝線維化の評価[招待有り]ポスター発表
- 第46回日本IVR学会総会, 2017年05月, 日本語, 日本IVR学会, 岡山, 国内会議動脈塞栓術を施行した腎部分切除術後の仮性動脈瘤の検討[招待有り]口頭発表（一般）
- 第46回日本IVR学会総会, 2017年05月, 日本語, 日本IVR学会, 岡山, 国内会議十二指腸静脈瘤に対するB-RTOの有効性の検討[招待有り]口頭発表（一般）
- 第46回日本IVR学会総会, 2017年05月, 日本語, 日本IVR学会, 岡山, 国内会議腫瘍性脊椎圧骨折に対する経皮的椎体形成術の検討[招待有り]口頭発表（一般）
- 第46回日本IVR学会総会, 2017年05月, 日本語, 日本IVR学会, 岡山, 国内会議IVR技術のいろは 超音波ガイド下穿刺技術のいろは公開講演，セミナー，チュートリアル，講習，講義等
- ISMRM 2017 annual Meeting, 2017年04月, 英語, International Society for Magnetic Resonance in Medicine, Honolulu, USA, Hybrid PET/MRI scanner is an emerging modality and utilized not only for oncological or neurological purposes but also for assessment of musculoskeletal disease. Simultaneous acquisition of PET and MRI enables precise anatomical localization of PET trace, 国際会議Whole body FDG PET/MR for assessment of facet joint osteoarthritis: Direct comparison of FDG uptake with MR and CT features[招待有り]ポスター発表
- 25th ISMRM Annual Meeting, 2017年04月, 英語, International Society of Magnetic Resonance Medicine, Honolulu, USA, 国際会議Quantitative Estimation of Liver Function using Gadoxetic Acid-Enhanced MR Imaging: in Vitro and in Vivo Comparison between R1 and R2* Relaxometry.[招待有り]ポスター発表
- 26th ISMRM Annual Meeting, 2017年04月, 英語, International Society of Magnetic Resonance Medicine, Honolulu, USA, 国際会議Estimation of Lobar Liver Function using Gadoxetic Acid-Enhanced MR Imaging: Comparison with 99mTc-GSA SPECT Imaging.[招待有り]ポスター発表
- Cardiovascular and Interventional Radiological Society of Europe, 2016年09月, 英語, Cardiovascular and Interventional Radiological Society of Europe, Barcelona, Spain, 国際会議Embolization for spontaneous adrenal hemorrhage.[招待有り]口頭発表（一般）
- Cardiovascular and Interventional Radiological Society of Europe, 2016年09月, 英語, Cardiovascular and Interventional Radiological Society of Europe, Barcelona, Spain, 国際会議Combination therapy using denosumab and transarterial embolization for symptomatic sacral giant cell tumor.[招待有り]口頭発表（一般）
- 第71回日本消化器外科学会総会, 2016年07月, 日本語, 徳島大学, 徳島, 国内会議膵神経内分泌腫瘍；CTにおける造影パターンと臨床病理学的所見の相関[招待有り]ポスター発表
- 日本インターベンショナルラジオロジー学会総会, 2016年05月, 日本語, 日本インターベンショナルラジオロジー学会, 名古屋, 国内会議ブタ肝後面下大静脈損傷モデルを用いたステントグラフトによる止血効果の検討[招待有り]口頭発表（一般）
- 日本インターベンショナルラジオロジー学会総会, 2016年05月, 日本語, 日本インターベンショナルラジオロジー学会, 名古屋, 国内会議ビーズ導入後のTACEの現状 多発肝細胞癌に対する非選択的DEB-TACEの有用性の検討[招待有り]口頭発表（一般）
- The 12th Asia-Pacific Congress of Cardiovascular and Interventional Radiology, 2016年04月, 英語, Asia-Pacific society of Cardiovascular and Interventional Radiology, Suzhou, CHINA, 国際会議Angiographic classification of uterine artery may predict failure of UAE for postpartum hemorrhage[招待有り]口頭発表（一般）
- 101st Radiological Society of North America, 2015年11月, 英語, Radiological Society of North America, Chicago, United States, 国際会議Single-Energy Metal Artifact Reduction Algorithm: Utility for Improvements of Image Quality on Dynamic Contrast-enhanced CT in Patients who Underwent Surgical or Endvascular Treatment for Hepatocellular Carcinoma[招待有り]口頭発表（一般）
- 101st Radiological Society of North America, 2015年11月, 英語, Radiological Society of North America, Chicago, United States, 国際会議Natural Progression of Liver Imaging Reporting and Data System Category 4 (LI-RADS 4) Nodules in the Cirrhotic Liver: Risk Factors Predicting Upgrade to Definite Hepatocellular Carcinoma[招待有り]ポスター発表
- 101st Annual Meeting of Radiological Society of North America, 2015年11月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Fast Advanced Spin Echo Diffusion-Weighted Imaging in the Abdomen.[招待有り]ポスター発表
- 第43回日本磁気共鳴医学会大会, 2015年09月, 日本語, 日本磁気共鳴医学会, 東京, 国内会議上腹部FASE-DWIの検討[招待有り]口頭発表（一般）
- 第43回日本磁気共鳴医学会大会, 2015年09月, 日本語, 日本磁気共鳴医学会, 東京, 国内会議上腹部Computed DWIの検討[招待有り]ポスター発表
- 第43回日本磁気共鳴医学会大会, 2015年09月, 日本語, 日本磁気共鳴医学会, 東京, 国内会議4D-PCA法による肝血管の描出能評価と血行力学的評価の初期経験[招待有り]口頭発表（一般）
- 23rd Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine, 2015年05月, 英語, International Society for Magnetic Resonance in Medicine, Toronto, Canada, 国際会議Time-SLIP Non-Contrast MR Hepatic Arteriography: Comparison with Contrast-Enhanced CT Arteriography.[招待有り]ポスター発表
- 23rd International Society of Magnetic Resonance in Medicine, 2015年05月, 英語, Society of Magnetic Resonance in Medicine, Toronto, Canada, 国際会議Repeatability of MRI-based Liver Fat and Iron Quantification using a Multistep Adaptive Fitting Algorithm[招待有り]ポスター発表
- 第74回日本医学放射線学会学術集会, 2015年04月, 日本語, 日本医学放射線学会, 横浜, 国内会議肝細胞癌術前のダイナミックCT：腫瘍診断とCTA の両立を意図したボーラストラッキング法の最適化[招待有り]口頭発表（一般）
- 第74回日本医学放射線学会学術集会, 2015年04月, 日本語, 日本医学放射線学会, 横浜, 国内会議3T装置を用いた上腹部Computed DWI[招待有り]口頭発表（一般）
- 第74回日本医学放射線学会学術集会, 2015年04月, 日本語, 日本医学放射線学会, 横浜, 国内会議3T装置を用いたTime-SLIP法肝動脈MRA：造影CTAとの比較[招待有り]口頭発表（一般）
- Annual Meeting of European Congress of Radiology 2015, 2015年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議Pretreatment CT Assessment of Patients with Hepatocellular Carcinoma: Optimization of Bolus Tracking Technique for Tumor Diagnosis and Visualization of Artery.[招待有り]ポスター発表
- Annual Meeting of European Congress of Radiology 2015, 2015年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議Evaluation of Time-SLIP Non-Contrast MR Hepatic Arteriography in Comparison with Contrast-Enhanced CT Arteriography.[招待有り]ポスター発表
- Annual Meeting of European Congress of Radiology 2015, 2015年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議Abdominal Computed Diffusion-Weighted Images at 3T-MRI.[招待有り]ポスター発表
- 第60回関西IVR研究会, 2015年, 日本語, 日本IVR学会, 大阪, 国内会議当院における薬剤溶出性球状塞栓物質を用いたTACE(DEB-TACE)の初期経験口頭発表（一般）
- 第42回日本磁気共鳴医学会大会, 2014年09月, 日本語, 日本磁気共鳴医学会, 京都, 国内会議3T装置を用いた上腹部Computed DWI．[招待有り]口頭発表（一般）
- 第42回日本磁気共鳴医学会大会, 2014年09月, 日本語, 日本磁気共鳴医学会, 京都, 国内会議3T装置を用いたTime-SLIP 法肝動脈MRA：造影CTAとの比較．[招待有り]口頭発表（一般）
- 22nd Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine & Joint Annual Meeting ISMRM-ESMRMB 2014, 2014年05月, 英語, International Society for Magnetic Resonance in Medicine, Milan, Italy, 国際会議Time-SLIP MR hepatic Arteriography using 3T-MRI.[招待有り]ポスター発表
- 第73回日本医学放射線学会総会, 2014年04月, 英語, 日本医学放射線学会, 横浜, 国内会議Optimization of Scan Interval in Abdominal CT Perfusion.[招待有り]口頭発表（一般）
- 第73回日本医学放射線学会総会, 2014年04月, 英語, 日本医学放射線学会, 横浜, 国内会議Optimization of Contrast Enhancement Technique in Abdominal CT Perfusion.[招待有り]口頭発表（一般）
- 第73回日本医学放射線学会総会, 2014年04月, 英語, 日本医学放射線学会, 横浜, 国内会議Computed Diffusion-Weighted Image in the Abdomen: Initial Experience.[招待有り]口頭発表（一般）
- 第73回日本医学放射線学会総会, 2014年04月, 英語, 日本医学放射線学会, 横浜, 国内会議Abdominal CT Perfusion: Effects of Breath Control Technique.[招待有り]口頭発表（一般）
- Annual Meeting of European Congress of Radiology 2014, 2014年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議T-SLIP MR Hepatic Arteriography at 3T.[招待有り]ポスター発表
- Annual Meeting of European Congress of Radiology 2014, 2014年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議Optimization of Scan Interval in Abdominal CT Perfusion.[招待有り]ポスター発表
- Annual Meeting of European Congress of Radiology 2014, 2014年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議Optimization of Contrast Enhancement Technique in Abdominal CT Perfusion.[招待有り]ポスター発表
- Annual Meeting of European Congress of Radiology 2014, 2014年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議Optimization of Bolus Tracking Technique in Abdominal Dual-Arterial Multi-Phasic CT for Arteriography and Tumor Diagnosis.[招待有り]ポスター発表
- Annual Meeting of European Congress of Radiology 2014, 2014年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議Computed Diffusion-Weighted Image in the Abdomen.[招待有り]ポスター発表
- Annual Meeting of European Congress of Radiology 2014, 2014年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議Abdominal CT with Single-Energy Metal Artifact Reduction (SEMAR): Initial Experiences.[招待有り]ポスター発表
- European Congress of Radiology, 2014年03月, 英語, European Society of Radiology, Vienna, Austria, 国際会議Abdominal CT with Single-Energy Metal Artifact Reduction (SEMAR): Initial Experiences[招待有り]ポスター発表
- Annual Meeting of European Congress of Radiology 2014, 2014年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議Abdominal CT Perfusion: Effects of Breath Control Technique.[招待有り]ポスター発表
- 第59回関西IVR研究会, 2014年, 日本語, 日本IVR学会, 大阪, 国内会議当院における非外傷性特発性後腹膜出血に対する動脈塞栓術の検討口頭発表（一般）
- 第58回関西IVR研究会, 2014年, 日本語, 日本IVR学会, 大阪, 国内会議巨細胞動脈炎の関与が疑われる両側上腕動脈病変に対しPTAを施行した2例口頭発表（一般）
- The 99th Radiological Society of North America, Scientific Assembly and Annual Meeting., 2013年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Non-contrast MR Hepatic Arteriography Using T-SLIP at 3T.[招待有り]ポスター発表
- 99th Annual Meeting of Radiological Society of North America, 2013年11月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Optimization of Contrast Medium Administration in CT Perfusion in the Abdomen.[招待有り]ポスター発表
- 99th Annual Meeting of Radiological Society of North America, 2013年11月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Optimization of Acquisition Interval in Abdominal CT Perfusion Measurement.[招待有り]ポスター発表
- 99th Annual Meeting of Radiological Society of North America, 2013年11月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Non-contrast MR Hepatic Arteriography Using T-SLIP at 3T.[招待有り]ポスター発表
- 99th Annual Meeting of Radiological Society of North America, 2013年11月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Abdominal CT Perfusion: Breathhold or Free Breathing?[招待有り]ポスター発表
- 第41回日本磁気共鳴医学会大会, 2013年09月, 日本語, 日本磁気共鳴医学会, 徳島, 国内会議3T 装置を用いた上腹部computed DWI の初期的検討．[招待有り]口頭発表（一般）
- 第41回日本磁気共鳴医学会大会, 2013年09月, 日本語, 日本磁気共鳴医学会, 徳島, 国内会議3T 装置を用いたTime-SLIP 法肝動脈MRA．[招待有り]口頭発表（一般）
- 関西IVR地方会, 2013年06月, 日本語, 関西IVR学会, 大阪, 国内会議腹腔動脈起始部狭窄に伴う下膵十二指腸動脈瘤破裂に対するTAE後に十二指腸狭窄をきたした1例[招待有り]口頭発表（一般）
- 日本IVR学会第33回関西地方会, 2013年02月, 日本語, 日本IVR学会, 大阪, 国内会議鎖骨下静脈からの中心静脈カテーテル挿入に伴う胸肩峰動脈損傷に対して動脈塞栓術を施行した2例[招待有り]口頭発表（一般）
- Cardiovascular Interventional Radiology Society of Europe, 2012年09月, 英語, Society of Cardiovascular Interventional Radiology Society of Europe, Lisbon, Portugal, 国際会議Successful balloon-occluded retrograde transvenous obliteration (BRTO) with cyanoacrylate under temporary portal venous occlusion for duodenal varices.[招待有り]ポスター発表
- Cardiovascular Interventional Radiology Society of Europe, 2012年09月, 英語, Society of Cardiovascular Interventional Radiology Society of Europe, Lisbon, Portugal, 国際会議Life-threatening brain edema caused by acute occlusion of superior vena cava stent.[招待有り]ポスター発表
- The 10th Asian-Pacific Congress of Cardiovascular and Interventional Radiology, 2012年05月, 英語, Asian-Pacific Congress of Cardiovascular and Interventional Radiology, Kobe, 国際会議Safety and efficacy of primary metallic biliary stent placement with tract embolization in patients with massive ascites.[招待有り]口頭発表（一般）
- 第39回日本IVR学会総会, 2010年05月, 日本語, 日本IVR学会, 東京, 国内会議短絡路作成のためのコアキシャル穿刺針の考案[招待有り]口頭発表（一般）
- Asiancongressofabdominalradiology, 2007年06月, 英語, Asian congress of abdominal radiology, 宮崎, 国際会議A case of hemangiopericytoma in the retroperitoneum[招待有り]ポスター発表
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 川崎医科大学, 2024年04月01日 - 2027年03月31日CTとMRIによる膵癌の早期診断法の確立と癌リスク特定によるスクリーニングへの展開
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 大阪大学, 2024年04月01日 - 2027年03月31日人工知能画像診断システムおよびラジオミクスの信頼性：日常臨床への普及を目指して
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2023年04月01日 - 2026年03月31日ドライバー遺伝子に基づくTACE治療反応性の血清バイオマーカーの開発
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2023年04月01日 - 2026年03月31日肝細胞癌に対する免疫療法の治療効果を予測する非侵襲的バイオマーカー開発
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2022年04月01日 - 2026年03月31日大動脈瘤のMRエラストグラフィ：瘤の「硬さ」はEVAR後の再増大を予測しうるか？健常人ボランティア複数人に対し、大動脈のMRエラストグラフィの撮像を行った。 肝のMRエラストグラフィと同様のパラメータで撮像を行うと、血管壁の弾性率の測定が不可能であり、肝より深部に血管が存在することや、周囲臓器との関係が原因と考えている。Amplitudeなどのパラメータの設定、あるいはpassive driverの位置を調整し、周囲臓器や骨などを避けて振動を与えるなどの工夫を行っているが、現時点で安定した撮像方法は確立できていない。 一方で、基礎実験のため、3Dプリンターを用いた大動脈血管モデルを作成した。上記にて撮像方法をある程度確立した後に、ステントグラフトを留置し、瘤腔に血栓を作成した血管モデルで実験を行う予定である。瘤腔の血栓については、凝固血液やヘパリン化した非凝固血液を使用する予定であり、これについてはin vitroでの検証は行っているが、実際の血管モデルでの作成には至っていない（撮像時に作成予定である）。
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2022年04月01日 - 2025年03月31日人工知能を用いた膵癌CT自動診断システム開発とスクリーニング・早期診断への応用腹部造影CT画像に対して画像AI技術を用い、膵腫瘤および膵癌に付随する頻度の高い二次所見（主膵管拡張、主膵管狭窄、膵萎縮）の自動検出による膵癌自動診断システムの構築を試みた。深層学習を用いて、膵実質、膵管、腫瘤の各領域を自動抽出し、抽出結果に基づき膵腫瘤性病変ならびに二次所見の有無を判定可能なAIエンジンを構築した。トレーニングセット・バリデーションセットとして膵癌群587例、対照群432例を用い、テストデータとして関連施設より収集した膵癌群62例、対照群90症例を対象に、膵腫瘤検出AI単独による膵癌検出精度ならびに膵腫瘤検出AIと二次所見検出AIの組合せによる膵癌検出精度を評価・算出した。 テストデータにおける腫瘤検出AIのみによる膵癌検出能は、感度73.3%、特異度96.7%であった。腫瘤検出AIと二次所見検出AIの組合せによる膵癌検出能は、感度93.5%、特異度84.4%であった。二次所見検出AIを組み合わせることにより検出感度が向上するとともに、腫瘤検出AI単独では検出できなかったTisやT1等の小膵癌に対しても検出成功例が増加した。
- 兵庫県医師会, 勤務医事業医学研究助成, 2024年04月 - 2025年03月, 研究代表者早期膵癌の発見を目的とした人工知能によるCT自動診断システム開発
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2021年04月01日 - 2024年03月31日, 研究分担者門脈血流・肝機能定量MRIによる分離門脈血流・肝機能評価の検討実験用ファントムを用いたMRI基礎研究によって門脈分枝血流および分肝機能評価（Gd-EOB-DTPA造影剤の定量測定）に最適なパラメータを設定する。次に肝癌術前症例に対して門脈血流・肝機能定量MRIを実施し、各区域の門脈血流量および肝機能を定量測定することで普遍的な分離門脈血流・肝機能評価を行う。つまりMRIで定量的門脈血流ならびに肝機能測定を行い、術前・術後の肝区域毎の分肝機能を定量し、区域レベルでの詳細な機能評価・機能推移を実現する。将来的に肝切除対象例における残存予定区域のみで算出されたより精度の高い肝予備能評価法を確立することを目標としている。現在動態ファントムを用いた血流評価の準備を進めている。また現在使用されている造影MRIの肝血流と肝機能の関連を検討し、学会発表予定である。
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2020年04月01日 - 2023年03月31日, 研究分担者肝動脈塞栓術後のガン微小環境におけるマクロファージ極性制御に基づく新規治療戦略luciferase遺伝子導入N1S1ラット肝癌細胞を用いて同種移植肝癌モデルを作成した。腫瘍移植後7日目に頸動脈より細経のマイクロカテーテルを挿入し、肝動脈を選択し、破砕したゼラチン物質にて腫瘍動脈の塞栓術を行った。さらに1週間後にIVISにて腫瘍壊死および残存組織の発光をIVISにて確認した。その後、Sacrificeを行 い、肝癌移植・辺縁部をまとめて摘出し、組織切片を作成、免疫染色を行った。CD68およびCD206抗体による免疫染色にて、M1型の炎症性マクロファージとTGF- β1産生細胞が集積する腫瘍関連マクロファージの多寡を評価した。動脈塞栓群では、CD206陽性の腫瘍関連マクロファージ(=TAM)の割合（CD206/CD68）が有意に増加し、Lenvatinib投与群では有意に減少していた。また、PPFEよりmRNA抽出を行い、microarrayによる網羅的遺伝子解析を行った。TAE群ではTAMに関与する遺伝子群の発現が増加傾向にあり、これらはLenvatinib併用群では減少する傾向にあった。TAEにより生じた腫瘍免疫微小環境のTAM増加に向かう変化がLenvatinibにより修正されうる可能性が示唆された。ついでラット脛骨より骨髄細胞を採取し、M－CSF投与によりマクロファージへと分化させた。同骨髄由来マクロファージとN1S1細胞を用いてマクロファージ極性変化を評価した。Lenvatinibとマクロファージのみに投与しても極性変化は見られなかったが、N1S1のConditioned mediumを加えるとマクロファージ極性変化が生じ、Lenvatinib投与により改善が見られた。よって、Lenvatinibはマクロファージに作用するのではなく、腫瘍細胞に作用し、その結果、腫瘍より放出されるサイトカインによりマクロファージ極性変化が生じることが予想される。
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2019年04月01日 - 2023年03月31日, 研究代表者ヨードマップを用いた膵癌の線維性間質定量による悪性度および治療抵抗性の予測法確立本研究の目的はDual-Energy CTで撮像したダイナミック造影CTから得られるヨードマップを用いて膵癌内部の線維性間質の多寡を定量測定することにより、非侵襲的に膵癌の悪性度ならびに治療抵抗性の予測を行うことである． 最終目的の前の先行研究として、膵癌線維化マーカーであるCollagen fiberならびに活性化膵星細胞と予後との関連を後方視的に評価した。2008年から2017年の間に神戸大学病院において膵癌に対して手術加療が行われた通常型膵管癌162症例に対してCollagen量を評価するEVG染色、活性化膵星細胞を評価するα-SMA染色を行った。それぞれの全体における染色割合をPhotoshopで算出し、その多寡で予後を評価した所、Collagen fiberが高度な膵癌は軽度な膵癌と比較して生存率が有意に延長（Log-rank test P=0.001）、α-SMA陽性細胞が高度の膵癌は軽度な膵癌と比較して生存率が有意に延長していた（Log-rank test P=0.001）。また線維化高度な膵癌では腫瘍内のCD8陽性T細胞が多いことも判明した。この結果から、膵癌においては線維化が高度な症例で予後が良く、腫瘍内免疫状態とも関連している可能性が示唆された。 続いて、上記対象162膵癌に対して造影CT平衡相画像から線維化を予測可能かを評価した。線維化予測指標としてECV fractionを利用して18例において評価を行った所、ECV fractionとCollagen fiberの程度に中等度の相関が見られたが（ρ=0.641、P=0.034）、α-SMA陽性細胞との程度には相関は認められなかった（ρ=0.352、P=0.289）。造影CT平衡相における評価は検討症例数を増やすとともに、ヒストグラム解析の追加を検討している。 また、Dual-Energy CTを用いた膵癌線維性間質の評価を行うための研究に対して倫理委委員会の承認が得られ、実施体制を整えることができた。
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2019年04月01日 - 2023年03月31日, 研究分担者血流・組織解析CTによる肝細胞癌分子標的療法の治療効果および肝不全予測法の確立本研究の目的は、Dual-Energy CTの組織物質弁別画像による血流・組織解析法を用い て肝細胞癌に対する分子標的薬の治療効果ならびに背景肝実質への影響を同時に評価する ことである。 進行肝細胞癌に対してレンバチニブ投与予定の患者に対して、当院にて配備されているDual-Energy CT装置（Siemens社SOMATOM Force）を用いて治療前7日以内、治療後1ヶ月、2ヶ月後にダイナミック造影CTを施行した19名に対して画像評価を行った。撮像条件として、ファントム実験でヨード定量の安定性が高かった100kVと150SnkVの管電圧、reference mAs 240mAsの組み合わせで撮像を行った。ダイナミック造影CTとして体重あたり600mgIの造影剤を30秒間で静脈注入し、動脈相・門脈相・平衡相の撮像を行った。 mRECISTで治療効果判定を行ったところ、1ヶ月後・2ヶ月後の奏効率はそれぞれ21%・37%であり、過去文献での奏効率40.6%と近い値を示した。一方でChoi criteriaで評価を行った場合には奏効率は47%・47%と上昇しており、mRECISTでの評価よりも早期に奏効が得られる症例が増えており、内部血流低下を鋭敏に検知できていることが証明された。また、動脈相のヨードマップで腫瘍内部のCT値を測定すると治療前36.9に対して1ヶ月後28.2、2ヶ月後19.6と減少していた。 上記の結果から、少数例での検討ではあるがヨードマップで肝細胞癌内部のヨード値を測定することでレンバチニブの治療効果である腫瘍新生血管の阻害効果を適切に評価できることが示唆された。
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 近畿大学, 2017年04月01日 - 2022年03月31日, 研究分担者ボランティア実験、臨床例の検討のため施設倫理委員会の承認が得られた。 （1）ヒトによるヨード密度値の定量測定と最適なパラメーターの確立のため、正常肝を有するボランティア患者10 名および，生検にて組織学的に肝線維化が評価されたウイルス性慢性肝炎・肝硬変を有する臨床患者に対して，DECTによる造影ダイナミックCT撮像を行いデータ収集を行なった。慢性肝炎（組織学的な線維化スコアF0-3），肝硬変（F4）患者それぞれ30 名（計60名）を目標としたが、集積終了した。CT撮像は通常の臨床で行われる撮像方法に従い，各相でのヨード密度画像を作成し，ヨード密度をROIにて測定する． そのデータをもとに，肝線維化と関連のあるパラメーターを探索する． 現在のところ、以下のようにヨード停滞率（residual ratio）が良好なパラメーターである可能性が分かっている。 検討方法：線維化スコアF0からF4までの各群と肝実質のヨード[水]密度を比較検討した。結果：単純、門脈相、平衡相での肝実質のヨード[水]密度を順にIn、Ip、Ieとすると、(Ie-In)-(Ip-In)=Ie-Ip（門脈相から平衡相の密度の傾き）は、F0, -9.4±2.0; F1, -10.2±1.6; F2, -8.4±1.7; F3, -7.5±2.8; F4, -3.9±3.5であり、Ie-Ipと線維化スコアとの間に有意な相関がみられた（r=0.699, p<0.001）。また、cutoffを-4.0にした場合のF0-3とF4の弁別の感度は80％、特異度は93.9％であった。この結果の学会、論文発表を行った。
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2016年04月01日 - 2019年03月31日, 研究分担者本研究はウサギ腫瘍モデルに対する炭酸飽和水動注療法の抗腫瘍効果および抗癌剤(シスプラチン)の増感作用を検討することを企図したものである。 肝臓に腫瘍（VX2）を移植した日本白ウサギ40羽に対して、移植後3週に肝動脈まで挿入したカテーテルより炭酸ガス飽和水を注入した。対象をコントロール群、炭酸群、シスプラチン群、混合群の4群に分け、注入3日目、7日目に造影CTでの腫瘍体積を計測を行い、7日目に安楽死後、低酸素やアポトーシスの評価を行った。 結果は炭酸群、混合群で腫瘍増大効果の抑制がみられ、炭酸関連の2群では低酸素、アポトーシスの誘導が認められた。さらに混合群ではシスプラチン増感作用が示唆された。競争的資金
- 日本学術振興会, 科学研究費助成事業, 若手研究(B), 神戸大学, 2015年04月01日 - 2019年03月31日, 研究代表者MRIによる肝の脂肪定量の際に同時に得られるR2*値を利用してGd-EOB-DTPA造影剤の取り込みを定量・数値化できるかどうかの研究を行った． ファントム実験においてはR2*値による造影剤定量は，R1値による造影剤定量とほぼ同等の定量精度が得られることが分かった．臨床研究においては血液生化学的な指標であるMELD scoreやICG 15分停滞率との相関が得られ，R2*値による肝機能定量の有用性が示唆された．一方で，画質の安定性が悪く特に肝左葉では計測値に信頼性が乏しいこと，背景肝実質への過剰鉄沈着例においては定量ができないことが判明し，R2* mapでの肝機能定量における限界と考えられた．競争的資金
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 2014年04月01日 - 2019年03月31日, 研究分担者Dual Energy CT（DECT）は、異なるエネルギーのX線データを用いて、そのX吸収値の変化から特定の物質を分別できる可能性がある。本研究では、肝硬変、脂肪肝、NASHなどの病変に現れる特定の物質や投与薬剤の病変内への到達量を定量測定できるDECTによる複合物質分別処理技術（MMD: Multi Material Decomposition）を開発した。これにより、肝細胞癌リスクと関係する肝の脂肪沈着、線維化の程度や、シスプラチンなどの金属を含む抗がん剤の腫瘍到達量を定量的に診断できる非侵襲的早期肝疾患診断技術（仮想CT肝生検）を可能とした。
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2014年04月01日 - 2017年03月31日, 研究分担者ボランティアでの血流量・流速は妥当と考えられ、せん断応力(WSS,OSI,SWSSG,GON)は大血管で高値となり動静門脈を分離可能であった。 肝疾患28症、他24例では、流量・流速は低下、せん断応力は動脈で個人差が増大した。脈管判別能はせん断応力が優れた。Gd併用が有用であった。疾患群でSMA血流の低下、SMAのOSI、SPA・PVのGON上昇と門脈流速低下、胆管障害例で肝動脈血流増加がみられた。Child-Pughスコアの上昇に伴い腹腔動脈系のせん断応力上昇、門脈血流量減少、肝静脈GONの低下がみられた。解析は約40分程度であった。 血管性状変化の解明と機能評価における有用性が示された。競争的資金
- 一般社団法人神緑会, 2016年06月 - 2017年03月, 研究代表者神緑会研究助成金競争的資金
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2013年04月01日 - 2016年03月31日, 研究分担者外傷性肝後面下大静脈損傷に対する新しい血管内治療法の開発を目的として、本研究を行った。まず最初に、ブタを用いて新しいバルーンカテーテルの開発実験を行ったが、有効な下大静脈灌流が得られず、形状の変更を余儀なくされた。第二段階として、これまでに報告のないブタ肝後面下大静脈損傷モデルの作成に成功した。 引き続き、同損傷モデルに対して血管内治療による止血が可能か否かを検証したところ、ステントグラフトによる止血効果を確認し得た。そこで、ステントグラフトと同等の止血効果を有し、かつ抜去可能な新しいデバイスの開発を進めた。現在デバイス改良の最終段階に入っており、追加実験を行い、早期の完成を目指している。競争的資金
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2013年04月01日 - 2016年03月31日, 研究分担者我々は、以前に血管内治療手技を用いてブタにおける急性B型大動脈解離モデルを作成することに成功し、研究成果を報告している。今回の研究では、より安定した偽腔開存型の急性B型大動脈解離モデルを作成することを検討し、慢性期経過観察も行い、解離性大動脈瘤モデルの作成を検討した。急性期解離においては従来より安定したモデルが作成できた。慢性期では6頭のうち3頭で径の拡大を認め、解離性大動脈瘤モデルとして期待できるものであった。解離性大動脈瘤モデルを低侵襲な手技で作成できたることは、今後の本疾患に対しての治療的な研究を遂行していく上で、多大な貢献をすることができると考える。競争的資金
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2013年04月01日 - 2016年03月31日炭酸ガス溶解液の抗腫瘍効果を調べるため、ウサギVX2腫瘍大腿移植モデルを使用し、炭酸ガス溶解液を経動脈的に注入した。炭酸ガス注入群とコントロール群に分け、腫瘍サイズの変化およびアポトーシス誘導の比較を行った。腫瘍サイズは造影CT、アポトーシスの評価はTUNEL染色およびcaspase-3によるウエスタンブロッティングを用いて行った。炭酸ガス注入群で、腫瘍増大率が有意に低く、アポトーシスの発現が有意に高かった。炭酸ガスの動脈注射によりCaspase-3を介したアポトーシスを生じ、VX2腫瘍サイズの増大が抑制されることが示された。競争的資金
- 日本医学放射線学会, 2013年04月 - 2014年03月, 研究代表者第10回日本医学放射線学会 バイエル研究助成競争的資金