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村上 卓道
大学院医学研究科 医科学専攻
教授

研究者基本情報

■ 学位
  • 医学博士, 大阪大学
■ 研究キーワード
  • 肝腫瘍治療
  • 造影剤
  • MRI
  • CT
  • dynamic CT/MR study
  • 腹部
  • 4D CT and MR imaging
  • Dual energy CT
  • MRガイド下集束超音波治療
  • 肝機能診断
  • 腹部領域のdynamic CT/MR study
  • 放射線科学
  • Radiology
■ 研究分野
  • ライフサイエンス / 放射線科学
■ 委員歴
  • 2013年 - 現在, 日本放射線腫瘍学会, 放射線治療専門医制度委員
  • 2013年 - 現在, 大阪がん予防検診センター, がん予防対策基金研究助成金選考委員
  • 2001年 - 現在, 日本血管造影,インターベンショナルラジオロジー学会, 評議員, 日本血管造影,インターベンショナルラジオロジー学会
  • 2000年 - 現在, 日本医学学放射線学会, 評議員、代議員、画像診断ガイドライン委員、専門医認定委員、造影剤安全性委員、JIRA標準化活動審議委員, 日本医学学放射線学会
  • 1998年 - 現在, 日本核磁気共鳴医学会, 評議員, 日本核磁気共鳴医学会
  • - 現在, Advanced CT・MR研究会, 幹事
  • - 現在, JIRA基準委員, 幹事
  • - 現在, 日本腹部造影エコー・ドプラ診断研究会, 世話人
  • - 現在, 日本肝癌研究会, プログラム委員、取扱規約委員
  • - 現在, 日本臨床腫瘍学会, がん薬物療法専門医制度委員会、専門医審査部会、試験問題検討小委員
  • - 現在, 日本肝臓学会, 肝癌診療ガイドライン改訂委員会、倫理委員会
  • - 現在, 大阪府医療人キャリアセンター, 運営協議会委員
  • - 現在, 大阪地方裁判所, 専門委員

研究活動情報

■ 受賞
  • 2018年11月 北米放射線学会(RSNA), CERTIFICATE OF MERIT AWARD, "New and Updated Topics in Targeted Therapies for the Treatment of Advanced and Metastatic Renal Cell Carcinoma: What Radiologists Should Know"
    Yoshiko Ueno, Tsutomu Tamada, Satoru Takahashi, Keitaro Sofue, Utaru Tanaka, Takamichi Murakami
    アメリカ合衆国
    国内外の国際的学術賞

  • 2004年 御園生賞
    日本国

  • 1997年 北米放射線学会(Certificate of Merit of RSNA)

  • 1996年 腹部CT.MR2学会大賞(Maguma Can Load of SBCT)

  • 1996年 北米放射線学会(RSNA): Certificate of Merit賞受賞

  • 1996年 Society of Computed Body Tomography and Magnetic Resonance: Cum Laude賞受賞

  • 1991年 北米放射線学会(Certificate of Merit of RSNA)

  • 1991年 北米放射線学会(RSNA): Certificate of Merit賞受賞

■ 論文
  • Shintaro Ichikawa, Keitaro Sofue, Yuko Nakamura, Toru Higaki, Hiroyuki Morisaka, Tomoko Hyodo, Takamichi Murakami, Kazuo Awai, Masahiro Jinzaki, Satoshi Goshima
    Abstract Advancements in computed tomography (CT) technology, particularly the emergence of dual-energy CT (DE-CT) and photon-counting detector CT (PCD-CT), can improve detection, characterization, and treatment monitoring of focal liver lesions. DE-CT, through its ability to differentiate tissues with similar densities and produce diverse datasets, has enhanced lesion visibility and diagnostic precision. PCD-CT further advances imaging with superior spatial resolution and material decomposition capabilities, offering potential for complex diagnostic scenarios. This review aimed to highlight the role of CT in hepatic imaging and its application to focal liver lesions. DE-CT improves lesion detectability using low-energy virtual monochromatic images, which enhance iodine contrast and reduce radiation and contrast agent doses. It also facilitates treatment response evaluation after locoregional therapies for hepatocellular carcinoma by quantifying biomarkers, such as the extracellular volume fraction. This review underscores the transformative impact of DE-CT and PCD-CT on liver imaging, emphasizing their complementary roles alongside magnetic resonance imaging. These innovations have paved the way for more precise diagnostics, improved treatment planning, and enhanced patient outcomes in the management of liver diseases.
    Ovid Technologies (Wolters Kluwer Health), 2025年04月, Investigative Radiology
    研究論文（学術雑誌）

  • Keigo Matsushiro, Tomoyuki Gentsu, Masato Yamaguchi, Koji Sasaki, Eisuke Ueshima, Takuya Okada, Ryota Kawasaki, Koji Sugimoto, Takamichi Murakami
    The Japanese Society of Interventional Radiology, 2025年03月, Interventional Radiology, 10, e2023 - 0048
    研究論文（学術雑誌）

  • Koji Sasaki, Takuya Okada, Masato Yamaguchi, Masashi Ozaki, Yutaro Okamoto, Akihiro Umeno, Tomoharu Yamanaka, Keigo Matsushiro, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Takamichi Murakami
    The Japanese Society of Interventional Radiology, 2025年03月, Interventional Radiology, 10, e2024 - 0018
    研究論文（学術雑誌）

  • Eisuke Ueshima, Keitaro Sofue, Shohei Komatsu, Nobuaki Ishihara, Masato Komatsu, Akihiro Umeno, Kentaro Nishiuchi, Ryohei Kozuki, Takeru Yamaguchi, Takanori Matsuura, Toshifumi Tada, Takamichi Murakami
    Background/Objectives: Although immunotherapy is the primary treatment option for intermediate-stage hepatocellular carcinoma (HCC), its efficacy varies. This study aimed to identify non-invasive imaging biomarkers predictive of the immunoscore linked to dynamic contrast-enhanced computed tomography (CECT). Methods: We performed immunohistochemical staining with CD3+ and CD8+ antibodies and counted the positive cells in the invasive margin (IM) and central tumor (CT), converting them to an immunoscore of 0 to 4 points. We assessed the dynamic CECT findings obtained from 96 patients who underwent hepatectomy for HCC and evaluated the relationship between dynamic CECT findings and immunoscores. For validation, we assessed the treatment effects on 81 nodules using the Response Evaluation Criteria in Solid Tumors in another cohort of 41 patients who received combined immunotherapy with atezolizumab and bevacizumab (n = 27) and durvalumab and tremelizumab (n = 14). Results: HCCs with peritumoral enhancement in the arterial phase (p < 0.001) and rim APHE (p = 0.009) were associated with the immunoscore in univariate linear regression analysis and peritumoral enhancement in the arterial phase (p = 0.004) in multivariate linear regression analysis. The time to nodular progression in HCCs with peritumoral enhancement in the arterial phase was significantly longer than that in HCCs without this feature (p < 0.001). Conclusions: We identified HCCs with peritumoral enhancement in the arterial phase as a noninvasive imaging biomarker to predict immune-inflamed HCC with a high immunoscore tendency. These HCCs were most likely to respond to combined immunotherapy.
    2025年03月, Cancers, 17(6) (6), 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Ryuji Shimada, Keitaro Sofue, Tianyuan Wang, Takeaki Ishihara, Eisuke Ueshima, Yoshiko Ueno, Akiko Kusaka, Takamichi Murakami
    Cine-magnetic resonance imaging (MRI) has been used to track respiratory-induced motion of the liver and tumor and assist in the accurate delineation of tumor volume. Recent developments in compressed sensitivity encoding (SENSE; CS) have accelerated temporal resolution while maintaining contrast resolution. This study aimed to develop and assess hepatobiliary phase (HBP) cine-MRI scans using CS. Phantom was imaged using cine-MRI and signal intensity (SI) and contrast ratio (CR) measured to determine the optimal flip-angle turbo field echo (TFE) prepulse delay. We performed cine-MRI in 20 patients for one minute, with images taken every 0.5 s after administration of gadoxetic acid contrast agent. Acquired images had three different acceleration factors (SENSE, CS without denoising [CS-no], and CS with strong denoising [CS-strong]). The image quality of the HBP cine MRI was quantitatively and qualitatively analyzed. In the phantom study, a flip angle of 30 °and TFE prepulse delay of 150 ms were optimal for clinical imaging. In a clinical study, CS-strong showed the highest signal-to-noise ratio and comparable contrast ratio among the three sequences. The CS-strong group showed a significantly higher image quality (P < 0.01), except for motion smoothness (P = 0.11). CS with denoising improved the tumor-to-liver contrast and image quality in high-temporal-resolution HBP cine MRI.
    2024年12月, Scientific reports, 14(1) (1), 31347 - 31347, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Eisuke Ueshima, Keitaro Sofue, Takahiro Kodama, Shuhei Yamamoto, Masato Komatsu, Shohei Komatsu, Nobuaki Ishihara, Akihiro Umeno, Takeru Yamaguchi, Masatoshi Hori, Takumi Fukumoto, Tetsuo Takehara, Takamichi Murakami
    Introduction: Immunotherapy is the first-line treatment for intermediate-advanced stage hepatocellular carcinoma (HCC), although its outcomes vary. This study aimed to identify imaging biomarkers of immunotherapy susceptibility linked to gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) and immune phenotypes, particularly immune-excluded phenotypes, with a tumor immune barrier.Methods: We performed immunohistochemical staining with a CD8+ antibody, and samples were classified into immune-inflamed, -intermediate, -excluded, and -ignored phenotypes. We assessed EOB-MRI findings obtained from 104 patients who underwent hepatectomy for HCC and evaluated the relationship between MRI findings and immune phenotype. Spatial transcriptome analysis of tumor tissues in each immune phenotype was performed to characterize the MRI findings. For validation, we analyzed the treatment effect on 60 nodules in another cohort of 27 patients who received combined immunotherapy using anti-programmed death-ligand 1 and anti-vascular endothelial growth factor (VEGF) antibodies.Results: HCCs with rim arterial phase hyperenhancement (APHE) (odds ratio [OR] 17.3 P=0.009), peritumoral enhancement on the arterial phase (OR 8.6, P<0.004), and intermediate intensity on the hepatobiliary phase (HBP) measured with a visual 3-point scale (OR 28.2, P=0.002) were associated with immune-excluded phenotype, where tumors tended to be larger and of the single nodular type with extranodular growth and confluent multinodular rather than the simple nodular type. Spatial transcriptome analysis revealed a spatial relationship among cytotoxic T lymphocytes, VEGF signals, and cancer-associated fibroblasts at the tumor-invasive margins in this phenotype. From the validation study, nodules with any one of these three imaging findings had a significantly prolonged time to-nodular progression (P=0.007, median not reached vs. 226 days).Conclusion: HCCs with rim APHE, peritumoral enhancement on arterial phase, and intermediate intensity on HBP with visual 3-point scale could be non-invasive biomarkers to predict the immune-excluded phenotype with tumor immune barrier. These HCCs were most likely to respond to the combined immunotherapy.
    S. Karger AG, 2024年11月, Liver Cancer, 1 - 26
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Hidetoshi Matsuo, Mizuho Nishio, Takaaki Matsunaga, Koji Fujimoto, Takamichi Murakami
    BACKGROUND/OBJECTIVES: This study aimed to investigate the accuracy of Tumor, Node, Metastasis (TNM) classification based on radiology reports using GPT3.5-turbo (GPT3.5) and the utility of multilingual large language models (LLMs) in both Japanese and English. METHODS: Utilizing GPT3.5, we developed a system to automatically generate TNM classifications from chest computed tomography reports for lung cancer and evaluate its performance. We statistically analyzed the impact of providing full or partial TNM definitions in both languages using a generalized linear mixed model. RESULTS: The highest accuracy was attained with full TNM definitions and radiology reports in English (M = 94%, N = 80%, T = 47%, and TNM combined = 36%). Providing definitions for each of the T, N, and M factors statistically improved their respective accuracies (T: odds ratio [OR] = 2.35, p < 0.001; N: OR = 1.94, p < 0.01; M: OR = 2.50, p < 0.001). Japanese reports exhibited decreased N and M accuracies (N accuracy: OR = 0.74 and M accuracy: OR = 0.21). CONCLUSIONS: This study underscores the potential of multilingual LLMs for automatic TNM classification in radiology reports. Even without additional model training, performance improvements were evident with the provided TNM definitions, indicating LLMs' relevance in radiology contexts.
    2024年10月, Cancers, 16(21) (21), 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 眼窩内蜂巣状軟部肉腫の1例
    廣田 功平, 神田 知紀, 小路田 泰之, 村上 卓道
    (公社)日本医学放射線学会, 2024年09月, 日本医学放射線学会秋季臨床大会抄録集, 60回, S491 - S491, 日本語

  • Aki Miyazaki, Mizuho Nishio, Atsushi Fujita, Masaaki Kohta, Yasuyuki Kojita, Shintaro Horii, Takashi Sasayama, Takamichi Murakami
    PURPOSE: Flow-diverter (FD) stents were developed to treat aneurysms that are difficult to treat with conventional coiling or surgery. This study aimed to compare usefulness of Silent MRA and TOF (time of flight) -MRA in patients with aneurysms after FD placement. MATERIALS AND METHODS: We retrospectively collected images from 22 patients with 23 internal carotid artery aneurysms treated with FD. Two radiologists conducted MRA and DSA experiments. In the first reading experiment, the radiologists evaluated the aneurysm filling by employing Silent MRA and TOF-MRA and utilizing the modified O'Kelly-Marotta (OKM) scale, a four-class classification system for aneurysms after FD placement. We then calculated the agreement between the modified OKM scale on MRA and the original OKM scale on DSA. In the second reading experiment, the radiologists rated blood flow within the FD using a five-point scale. RESULTS: The weighted kappa value of the OKM scale between DSA and TOF-MRA was 0.436 (moderate agreement), and that between DSA and Silent MRA was 0.943 (almost perfect agreement). The accuracies for the four-class classification were 0.435 and 0.870 for TOF-MRA and Silent MRA, respectively. The mean score of blood flow within FD for TOF-MRA was 2.43 ± 0.90 and that for Silent MRA was 3.04 ± 1.02 (P < 0.001). CONCLUSION: Silent MRA showed a higher degree of agreement than TOF-MRA in aneurysm filling with DSA. In addition, Silent MRA was significantly superior to TOF-MRA in depicting blood flow within the FD. Therefore, Silent MRA is clinically useful for the follow-up of patients after FD placement.
    2024年08月, Japanese journal of radiology, 英語, 国内誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Miho Tachibana, Munenobu Nogami, Junko Inoue Inukai, Feibi Zeng, Kazuhiro Kubo, Takako Kurimoto, Martin W Huellner, Yoshiko Ueno, Takahiro Tsuboyama, Izumi Imaoka, Takamichi Murakami
    PURPOSE: Minimal misregistration of fused PET and MRI images can be achieved with simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI). However, the acquisition of multiple MRI sequences during a single PET emission scan may impair fusion precision of each sequence. This study evaluated the diagnostic utility of time-synchronized PET/MRI using an MR active trigger and a Bayesian penalized likelihood reconstruction algorithm (BPL) to assess the locoregional extension of endometrial cancer. METHODS: Fifty-five patients with endometrial cancer who underwent pelvic 2-deoxy-2-[18F]fluoro-D-glucose PET/MRI were retrospectively evaluated. The PET emission time for the BPL reconstruction was determined by the MR active trigger of each MR sequence. The concordance rates of image interpretation with pathological T-staging, diagnostic performance for deep myometrial invasion (MI), and diagnostic confidence levels were evaluated by two readers and compared between time-synchronized, overlapping (conventional and simultaneous, but not time-synchronized), and sequential (not simultaneous) PET/MRI and MRI with diffusion-weighted imaging. Misregistration of the PET/MRI-fused images was determined by evaluating the differences in bladder dimensions. RESULTS: The T classification by time-synchronized PET/MRI was the most concordant with the pathological T classification for the two readers. Time-synchronized PET/MRI had a significantly higher diagnostic performance for deep MI and higher confidence level scores than overlapping PET/MRI for the novice reader (p = 0.033 and p = 0.038, respectively). The differences in bladder dimension on sequential PET/MRI were significantly larger than those on overlapping and time-synchronized PET/MRI (p <0.001). CONCLUSION: Time-synchronized PET/MRI is superior to conventional PET/MRI for assessing the locoregional extension of endometrial cancer.
    2024年08月, European journal of radiology, 179, 111678 - 111678, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yoshiko Ueno, Keitaro Sofue, Tsutomu Tamada, Mitsuru Takeuchi, Naoya Ebisu, Kentaro Nishiuchi, Takuto Hara, Toshiki Hyodo, Hideaki Miyake, Takamichi Murakami
    PURPOSE: To compare the image quality, inter-reader agreement, and diagnostic capability for muscle-invasive bladder cancer (MIBC) of the reconstructed images in sections orthogonal to the bladder tumor obtained by 3D Dynamic contrast-enhanced (DCE)-MRI using the Golden-angle Radial Sparse Parallel (GRASP) technique with the images directly captured using the Cartesian sampling. MATERIALS AND METHODS: This study involved 68 initial cases of bladder cancer examined with DCE-MRI (GRASP: n = 34, Cartesian: n = 34) at 3 Tesla. Four radiologists conducted qualitative evaluations (overall image quality, absence of motion artifact, absence of streak artifact, and tumor conspicuity) using a five-point Likert scale (5 = Excellent/None) and quantitative signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) measurements. The areas under the receiver-operating characteristic curves (AUCs) for the Vesical Imaging-Reporting and Data System (VI-RADS) DCE score for MIBC assessment were calculated. Inter-reader agreement was also assessed. RESULTS: GRASP notably enhanced overall image quality (pooled score: GRASP 4 vs. Cartesian 3, P < 0.0001), tumor conspicuity (5 vs. 3, P < 0.05), SNR (Median 38.2 vs. 19.0, P < 0.0001), and CNR (7.9 vs. 6.0, P = 0.005), with fewer motion artifacts (5 vs. 3, P < 0.0001) and minor streak artifacts (5 vs. 5, P > 0.05). Although no significant differences were observed, the GRASP group tended to have higher AUCs for MIBC (pooled AUCs: 0.92 vs. 0.88) and showed a trend toward higher inter-reader agreement (pooled kappa-value: 0.70 vs. 0.63) compared to the Cartesian group. CONCLUSIONS: Using the GRASP for 3D DCE-MRI, the reconstructed images in sections orthogonal to the bladder tumor achieved higher image quality and improve the clinical work flow, compared to the images directly captured using the Cartesian. GRASP tended to have higher diagnostic ability for MIBC and showed a trend toward higher inter-reader agreement compared to the Cartesian.
    2024年08月, Japanese journal of radiology, 英語, 国内誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 田村 恵梨, 神田 知紀, 児玉 貴之, 元津 倫幸, 村上 卓道
    金原出版, 2024年07月, 臨床放射線, 69(4) (4), 567 - 572

  • 坪山 尚寛, 村上 卓道
    ＜文献概要＞今回のLessonのテーマは,"出血の有無は,子宮筋層腫瘤の良悪性の鑑別に全く役に立たない"ということである.肉腫はしばしば出血を伴うため,出血を伴う腫瘤は悪性を疑われがちであるが,良性病変でも出血はみられる.子宮筋層腫瘤は生検が困難で,さらに術中病理診断も難しいため,画像診断が治療方針に直結する.安易に悪性の可能性を示唆することは厳に慎むべきである.
    (株)Gakken, 2024年07月, 画像診断, 44(9) (9), 961 - 964, 日本語

  • 坪山 尚寛, 上野 嘉子, 戎 直哉, 今岡 いずみ, 村上 卓道
    ＜文献概要＞悪性リンパ腫の画像診断は不要な手術を避けるために重要であるが,婦人科領域ではかなりまれで,しばしば鑑別から抜け落ちてしまう。さらに,婦人科領域の悪性リンパ腫は幅広い年齢に発生するため,年齢から診断に迫ることができない。本稿では,子宮・卵巣の悪性リンパ腫を診断するポイントと鑑別疾患について解説する。
    金原出版(株), 2024年07月, 臨床放射線, 69(4) (4), 495 - 500, 日本語

  • Ryuji Shimada, Keitaro Sofue, Yoshiko Ueno, Tetsuya Wakayama, Takeru Yamaguchi, Eisuke Ueshima, Akiko Kusaka, Masatoshi Hori, Takamichi Murakami
    PURPOSE: To compare the utility of thin-slice fat-suppressed single-shot T2-weighted imaging (T2WI) with deep learning image reconstruction (DLIR) and conventional fast spin-echo T2WI with DLIR for evaluating pancreatic protocol. METHODS: This retrospective study included 42 patients (mean age, 70.2 years) with pancreatic cancer who underwent gadoxetic acid-enhanced MRI. Three fat-suppressed T2WI, including conventional fast-spin echo with 6 mm thickness (FSE 6 mm), single-shot fast-spin echo with 6 mm and 3 mm thickness (SSFSE 6 mm and SSFSE 3 mm), were acquired for each patient. For quantitative analysis, the SNRs of the upper abdominal organs were calculated between images with and without DLIR. The pancreas-to-lesion contrast on DLIR images was also calculated. For qualitative analysis, two abdominal radiologists independently scored the image quality on a 5-point scale in the FSE 6 mm, SSFSE 6 mm, and SSFSE 3 mm with DLIR. RESULTS: The SNRs significantly improved among the three T2-weighted images with DLIR compared to those without DLIR in all patients (P < 0.001). The pancreas-to-lesion contrast of SSFSE 3 mm was higher than those of the FSE 6 mm (P < 0.001) and tended to be higher than SSFSE 6 mm (P = 0.07). SSFSE 3 mm had the highest image qualities regarding pancreas edge sharpness, pancreatic duct clarity, and overall image quality, followed by SSFSE 6 mm and FSE 6 mm (P < 0.0001). CONCLUSION: SSFSE 3 mm with DLIR demonstrated significant improvements in SNRs of the pancreas, pancreas-to-lesion contrast, and image quality more efficiently than did SSFSE 6 mm and FSE 6 mm. Thin-slice fat-suppressed single-shot T2WI with DLIR can be easily implemented for pancreatic MR protocol.
    2024年06月, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 英語, 国内誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Takeru Yamaguchi, Keitaro Sofue, Eisuke Ueshima, Naoki Sugiyama, Shinji Yabe, Yoshiko Ueno, Atsuhiro Masuda, Hirochika Toyama, Takayuki Kodama, Masato Komatsu, Masatoshi Hori, Takamichi Murakami
    This study investigated the utility of imaging features, such as rim enhancement on contrast-enhanced CT (CECT), in predicting the prognosis of pancreatic ductal adenocarcinoma (PDAC). This retrospective study included 158 patients (84 men; mean age, 68 years) with pathologically confirmed PDAC. The following imaging features were evaluated on CECT by two radiologists: tumor size, tumor attenuation, and the presence of rim enhancement. Cox proportional hazards analysis was performed to identify the imaging and clinicopathological features for predicting disease-free survival (DFS) and overall survival (OS). Pathological features were compared with the presence of rim enhancement. Among the 158 patients, 106 (67%) underwent curative surgery (surgery group) and 52 (33%) received conservative treatment (non-surgery group). Rim enhancement was observed more frequently in the non-surgery group than in the surgery group (44% vs. 20%; p < 0.001). Rim enhancement showed significant associations with shorter DFS and OS in the surgery group (hazard ratios (HRs), 3.03 and 2.99; p < 0.001 and p = 0.003, respectively), whereas tumor size showed significant associations with shorter OS (HR per 1 mm increase, 1.08; p < 0.001). PDACs with rim enhancement showed significant associations with higher histological tumor grades (p < 0.001). PDAC with rim enhancement on CECT could predict poorer prognosis and more aggressive tumor grades.
    MDPI AG, 2024年04月, Diagnostics, 14(8) (8), 782 - 782
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 糖代謝制御機構における消化管グルコース排泄の意義についての解析
    森田 靖子, 坂口 一彦, 野上 宗伸, 曽 菲比, 西坂 まり華, 末松 那都, 山田 倫子, 細川 友誠, 菅原 健二, 廣田 勇士, 村上 卓道, 小川 渉
    (一社)日本糖尿病学会, 2024年04月, 糖尿病, 67(Suppl.1) (Suppl.1), S - 157, 日本語

  • Tomoyuki Gentsu, Masato Yamaguchi, Koji Sasaki, Ryota Kawasaki, Hiroki Horinouchi, Tetsuya Fukuda, Naokazu Miyamoto, Takeki Mori, Noriaki Sakamoto, Kensuke Uotani, Takanori Taniguchi, Yojiro Koda, Katsuhiro Yamanaka, Hiroaki Takahashi, Kenji Okada, Taro Hayashi, Toshitaka Watanabe, Yoshikatsu Nomura, Keigo Matsushiro, Eisuke Ueshima, Takuya Okada, Koji Sugimoto, Takamichi Murakami
    PURPOSE: The purpose of the study was to evaluate the efficacy and safety of pre-emptive transcatheter arterial embolization (P-TAE) of aortic side branches to prevent type II endoleak in patients with abdominal aortic aneurysm after endovascular abdominal aneurysm repair (EVAR). MATERIALS AND METHODS: This multicenter, prospective, single-arm trial enrolled 100 patients with abdominal aortic aneurysm from nine hospitals between 2018 and 2021. There were 85 men and 15 women, with a mean age of 79.6 ± 6.0 (standard deviation) years (range: 65-97 years). P-TAE was attempted for patent aortic side branches, including the inferior mesenteric artery, lumbar arteries, and other branches. The primary endpoint was late type II endoleak incidence at 6 months post-repair. Secondary endpoints included changes in aneurysmal sac diameter at 6- and 12 months, complications, re-intervention, and aneurysm-related mortality. Aneurysm sac changes at 6- and 12 months was compared between the late and no-late type II endoleak groups. RESULTS: Coil embolization was successful in 80.9% (321/397) of patent aortic side branches, including 86.3% of the inferior mesenteric arteries, 80.3% of lumbar arteries, and 55.6% of other branches without severe adverse events. Late type II endoleak incidence at 6 months was 8.9% (8/90; 95% confidence interval: 3.9-16.8%). Aneurysm sac shrinkage > 5 mm was observed in 41.1% (37/90) and 55.3% (47/85) of the patients at 6- and 12-months post-EVAR, respectively. Patients with late type II endoleak had less aneurysm sac shrinkage than those without type II endoleak at 12 months (-0.2 mm vs. -6.0 mm; P = 0.040). No patients required re-intervention for type II endoleak, and no aneurysm-related mortalities occurred. CONCLUSION: P-TAE is safe and effective in preventing type II endoleak, leading to early sac shrinkage at 12 months following EVAR.
    2024年03月, Diagnostic and interventional imaging, 英語, 国際誌
    研究論文（学術雑誌）

  • Koji Sasaki, Masato Yamaguchi, Tomoyuki Gentsu, Ryota Kawasaki, Naokazu Miyamoto, Kensuke Uotani, Noriaki Sakamoto, Tetsuya Fukuda, Hiroki Horinouchi, Takanori Taniguchi, Takeki Mori, Yojiro Koda, Katsuhiro Yamanaka, Hiroaki Takahashi, Kenji Okada, Toshitaka Watanabe, Taro Hayashi, Yoshikatsu Nomura, Keigo Matsushiro, Eisuke Ueshima, Takuya Okada, Koji Sugimoto, Takamichi Murakami
    PURPOSE: The occurrence of endoleaks, particularly type 2 endoleaks (EL2), is the primary cause of poor long-term prognosis after endovascular aneurysm repair (EVAR). This study aimed to evaluate the efficacy and safety of preemptive transcatheter arterial embolization (P-TAE) for aortic side branches (ASBs) to prevent EL2 before EVAR using the Excluder stent-graft system (EXCLUDER). MATERIALS AND METHODS: In this prospective, multicenter study, 80 patients (mean age, 79.1±6.7 years; 85.0% male patients; mean aneurysmal sac diameter, 48.4±7.4 mm) meeting the eligibility criteria were prospectively enrolled from nine hospitals. Before EVAR, p-TAE was performed to embolize the patent ASBs originating from the abdominal aortic aneurysm. Contrast-enhanced computed tomography was performed at 1 month and 6 months after EVAR. The primary endpoint was EL2 incidence at 6 months, and the secondary endpoints were aneurysmal sac diameter changes at 6 and 12 months, P-TAE outcomes, complications related to P-TAE, re-intervention, and aneurysm-related mortality. RESULTS: All patients successfully underwent P-TAE without serious complications. Coil embolization was successful in 81.6% of ASBs. EL2 incidence at 6 months was identified in 18/70 (25.7%) patients. Aneurysmal sac diameter shrinkage (≥5 mm) was observed in 30.0% of patients at 6 months and in 40.9% at 12 months. Only one patient required re-intervention for EL2 within 1 year of EVAR; aneurysm-related deaths were not observed. CONCLUSION: P-TAE for ASBs before EVAR using EXCLUDER is a safe and effective strategy. It aids in achieving early aneurysmal sac shrinkage and reduces EL2 re-intervention at 1 year after EVAR.
    2024年03月, Journal of vascular and interventional radiology : JVIR, 英語, 国際誌
    研究論文（学術雑誌）

  • Masashi Tajiri, Tomoyuki Gentsu, Masato Yamaguchi, Koji Sasaki, Eisuke Ueshima, Takuya Okada, Koji Sugimoto, Takamichi Murakami
    We report a case of a life-threatening ruptured renal angiomyolipoma (AML) that did not meet the criteria for prophylactic treatment (tumor >4 cm or intratumoral aneurysm >5 mm) during follow-up. A woman in her 70s was followed up for a 2.5-cm AML with a rich vascular component. An intratumoral aneurysm >5 mm was not identified for 2 years. She complained of a sudden abdominal pain with hypotension, and contrast-enhanced computed tomography revealed a retroperitoneal hematoma with contrast media extravasation from an intratumoral aneurysm. Emergency transcatheter arterial embolization was successfully performed using N-butyl cyanoacrylate glue. Rupture can occur in small AMLs or in AMLs not identified with intratumoral aneurysms during follow-up. AMLs with a rich vascular component at the kidney surface are more likely to rupture.
    2024年03月, Interventional radiology (Higashimatsuyama-shi (Japan), 9(1) (1), 20 - 25, 英語, 国内誌

  • Nobuaki Ishihara, Shohei Komatsu, Keitaro Sofue, Eisuke Ueshima, Yoshihiko Yano, Yoshimi Fujishima, Jun Ishida, Masahiro Kido, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Hiroaki Yanagimoto, Hirochika Toyama, Yoshihide Ueda, Yuzo Kodama, Takamichi Murakami, Takumi Fukumoto
    AIM: The IMbrave150 trial revealed that atezolizumab plus bevacizumab (AtezoBv) showed a higher objective response rate (ORR) in patients with advanced hepatocellular carcinoma (HCC). Although conversion therapy after AtezoBv has been recently reported, markers predictive of its efficacy, particularly radiological imaging markers, have not yet been identified. The present study focused on tumor morphological appearance on radiological imaging and evaluated whether it could be associated with AtezoBv efficacy. METHODS: Ninety-five intrahepatic lesions in 74 patients who were given AtezoBv for advanced HCC were recruited for evaluation. The lesions were divided into two groups, simple nodular (SN group) and non-simple nodular (non-SN group), based on the gross morphology on pretreatment imaging, and retrospectively evaluated for treatment response and other relevant clinical outcomes. RESULTS: Assessing the size of individual tumors after treatment, waterfall plots showed that tumor shrinkage in the non-SN group including 56 lesions was higher than that in the SN group comprising 39 lesions. The ORR was significantly higher in the non-SN group (39.3% vs. 15.4%, p = 0.012). Additionally, the median time to nodular progression was longer in the non-SN group (21.0 months vs. 8.1 months, p = 0.119) compared to the SN group. Six patients with non-SN lesions underwent sequential local therapy. CONCLUSIONS: Atezolizumab plus bevacizumab may show increased therapeutic efficacy in patients with tumors with a higher potential for aggressive oncological behavior, such as non-SN lesions. Treatment strategies focusing on conversion therapy may be crucial in patients with non-SN lesions.
    2024年02月, Hepatology research : the official journal of the Japan Society of Hepatology, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 心臓病変を認めたErdheim Chester病の1例
    杉山 直生, 橋村 宏美, 河野 淳, 野上 宗伸, 村上 卓道, 高橋 宗史, 藤川 良一, 伊澤 有, 鳥羽 敬義, 原 重雄
    (公社)日本医学放射線学会, 2024年02月, Japanese Journal of Radiology, 42(Suppl.) (Suppl.), 37 - 37, 日本語

  • 術前診断が困難であった後腹膜肺分画症の1例
    懸高 浩規, 曽 菲比, 立花 美保, 犬養 純子, 野上 宗伸, 村上 卓道, 神澤 真紀
    (公社)日本医学放射線学会, 2024年02月, Japanese Journal of Radiology, 42(Suppl.) (Suppl.), 40 - 40, 日本語

  • 仙骨に発生した褐色脂肪腫の1例
    重安 奈央子, 神田 知紀, 西岡 瑛子, 佐々木 康二, 元津 倫幸, 上嶋 英介, 上野 嘉子, 西尾 瑞穂, 橋村 宏美, 岡田 卓也, 祖父江 慶太郎, 河野 淳, 野上 宗伸, 山口 雅人, 堀 雅敏, 杉本 幸司, 村上 卓道, 小松 正人
    (公社)日本医学放射線学会, 2024年02月, Japanese Journal of Radiology, 42(Suppl.) (Suppl.), 32 - 32, 日本語

  • 野上 宗伸, 井上 純子, 曽 菲比, 立花 美保, 西谷 竜也, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2024年, 核医学, 61(1) (1), 51 - 51, 日本語

  • PET/MRIにおける胆汁のFDG集積に関する検討
    井上 純子, 野上 宗伸, 曽 菲比, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2024年, 核医学, 61(Suppl.) (Suppl.), S172 - S172, 日本語

  • 胸部領域PET/MRIにおける深層学習併用減弱補正法の再現性検討
    野上 宗伸, 松尾 秀俊, 西尾 瑞穂, 曽 菲比, 立花 美保, 井上 純子, 栗本 貴子, 久保 和広, 岡沢 秀彦, 村上 卓道
    (一社)日本核医学会, 2024年, 核医学, 61(Suppl.) (Suppl.), S173 - S173, 日本語

  • Takaaki Matsunaga, Atsushi Kono, Mizuho Nishio, Takahiro Yoshii, Hidetoshi Matsuo, Mai Takahashi, Takuya Takahashi, Yu Taniguchi, Hidekazu Tanaka, Kenichi Hirata, Takamichi Murakami
    BACKGROUND AND PURPOSE: Mean pulmonary artery pressure (mPAP) is a key index for chronic thromboembolic pulmonary hypertension (CTEPH). Using machine learning, we attempted to construct an accurate prediction model for mPAP in patients with CTEPH. METHODS: A total of 136 patients diagnosed with CTEPH were included, for whom mPAP was measured. The following patient data were used as explanatory variables in the model: basic patient information (age and sex), blood tests (brain natriuretic peptide (BNP)), echocardiography (tricuspid valve pressure gradient (TRPG)), and chest radiography (cardiothoracic ratio (CTR), right second arc ratio, and presence of avascular area). Seven machine learning methods including linear regression were used for the multivariable prediction models. Additionally, prediction models were constructed using the AutoML software. Among the 136 patients, 2/3 and 1/3 were used as training and validation sets, respectively. The average of R squared was obtained from 10 different data splittings of the training and validation sets. RESULTS: The optimal machine learning model was linear regression (averaged R squared, 0.360). The optimal combination of explanatory variables with linear regression was age, BNP level, TRPG level, and CTR (averaged R squared, 0.388). The R squared of the optimal multivariable linear regression model was higher than that of the univariable linear regression model with only TRPG. CONCLUSION: We constructed a more accurate prediction model for mPAP in patients with CTEPH than a model of TRPG only. The prediction performance of our model was improved by selecting the optimal machine learning method and combination of explanatory variables.
    2024年, PloS one, 19(4) (4), e0300716, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 佐々木 康二, 岡田 卓也, 山口 雅人, 岡本 雄太郎, 松代 啓吾, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2024年01月, 日本インターベンショナルラジオロジー学会雑誌, 38(3) (3), 166 - 175, 日本語

  • Mizuho Nishio, Takaaki Matsunaga, Hidetoshi Matsuo, Munenobu Nogami, Yasuhisa Kurata, Koji Fujimoto, Osamu Sugiyama, Toshiaki Akashi, Shigeki Aoki, Takamichi Murakami
    Elsevier BV, 2024年, Informatics in Medicine Unlocked, 46, 101465 - 101465
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Keitaro Sofue, Ryuji Shimada, Eisuke Ueshima, Shohei Komatsu, Takeru Yamaguchi, Shinji Yabe, Yoshiko Ueno, Masatoshi Hori, Takamichi Murakami
    XMLink, 2024年, Korean Journal of Radiology, 25(1) (1), 24 - 24
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Bachir Taouli, Ahmed Ba-Ssalamah, Julius Chapiro, Jagpreet Chhatwal, Kathryn Fowler, Tae Wook Kang, Gesine Knobloch, Dow-Mu Koh, Masatoshi Kudo, Jeong Min Lee, Takamichi Murakami, David J Pinato, Kristina I Ringe, Bin Song, Parissa Tabrizian, Jin Wang, Jeong Hee Yoon, Mengsu Zeng, Jian Zhou, Valérie Vilgrain
    2023年12月, European radiology, 英語, 国際誌

  • Hidetoshi Matsuo, Kazuhiro Kitajima, Atsushi K Kono, Kozo Kuribayashi, Takashi Kijima, Masaki Hashimoto, Seiki Hasegawa, Koichiro Yamakado, Takamichi Murakami
    BACKGROUND: Deep learning (DL) has been widely used for diagnosis and prognosis prediction of numerous frequently occurring diseases. Generally, DL models require large datasets to perform accurate and reliable prognosis prediction and avoid overlearning. However, prognosis prediction of rare diseases is still limited owing to the small number of cases, resulting in small datasets. PURPOSE: This paper proposes a multimodal DL method to predict the prognosis of patients with malignant pleural mesothelioma (MPM) with a small number of 3D positron emission tomography-computed tomography (PET/CT) images and clinical data. METHODS: A 3D convolutional conditional variational autoencoder (3D-CCVAE), which adds a 3D-convolutional layer and conditional VAE to process 3D images, was used for dimensionality reduction of PET images. We developed a two-step model that performs dimensionality reduction using the 3D-CCVAE, which is resistant to overlearning. In the first step, clinical data were input to condition the model and perform dimensionality reduction of PET images, resulting in more efficient dimension reduction. In the second step, a subset of the dimensionally reduced features and clinical data were combined to predict 1-year survival of patients using the random forest classifier. To demonstrate the usefulness of the 3D-CCVAE, we created a model without the conditional mechanism (3D-CVAE), one without the variational mechanism (3D-CCAE), and one without an autoencoder (without AE), and compared their prediction results. We used PET images and clinical data of 520 patients with histologically proven MPM. The data were randomly split in a 2:1 ratio (train : test) and three-fold cross-validation was performed. The models were trained on the training set and evaluated based on the test set results. The area under the receiver operating characteristic curve (AUC) for all models was calculated using their 1-year survival predictions, and the results were compared. RESULTS: We obtained AUC values of 0.76 (95% confidence interval [CI], 0.72-0.80) for the 3D-CCVAE model, 0.72 (95% CI, 0.68-0.77) for the 3D-CVAE model, 0.70 (95% CI, 0.66-0.75) for the 3D-CCAE model, and 0.69 (95% CI 0.65-0.74) for the without AE model. The 3D-CCVAE model performed better than the other models (3D-CVAE, p = 0.039; 3D-CCAE, p = 0.0032; and without AE, p = 0.0011). CONCLUSIONS: This study demonstrates the usefulness of the 3D-CCVAE in multimodal DL models learned using a small number of datasets. Additionally, it shows that dimensionality reduction via AE can be used to learn a DL model without increasing the overlearning risk. Moreover, the VAE mechanism can overcome the uncertainty of the model parameters that commonly occurs for small datasets, thereby eliminating the risk of overlearning. Additionally, more efficient dimensionality reduction of PET images can be performed by providing clinical data as conditions and ignoring clinical data-related features.
    2023年12月, Medical physics, 50(12) (12), 7548 - 7557, 英語, 国際誌
    研究論文（学術雑誌）

  • Bachir Taouli, Ahmed Ba-Ssalamah, Julius Chapiro, Jagpreet Chhatwal, Kathryn Fowler, Tae Wook Kang, Gesine Knobloch, Dow-Mu Koh, Masatoshi Kudo, Jeong Min Lee, Takamichi Murakami, David J Pinato, Kristina I Ringe, Bin Song, Parissa Tabrizian, Jin Wang, Jeong Hee Yoon, Mengsu Zeng, Jian Zhou, Valérie Vilgrain
    2023年11月, European radiology, 英語, 国際誌

  • Takaaki Matsunaga, Atsushi Kono, Hidetoshi Matsuo, Kaoru Kitagawa, Mizuho Nishio, Hiromi Hashimura, Yu Izawa, Takayoshi Toba, Kazuki Ishikawa, Akie Katsuki, Kazuyuki Ohmura, Takamichi Murakami
    RATIONALE AND OBJECTIVES: Pericardial fat (PF)-the thoracic visceral fat surrounding the heart-promotes the development of coronary artery disease by inducing inflammation of the coronary arteries. To evaluate PF, we generated pericardial fat count images (PFCIs) from chest radiographs (CXRs) using a dedicated deep-learning model. MATERIALS AND METHODS: We reviewed data of 269 consecutive patients who underwent coronary computed tomography (CT). We excluded patients with metal implants, pleural effusion, history of thoracic surgery, or malignancy. Thus, the data of 191 patients were used. We generated PFCIs from the projection of three-dimensional CT images, wherein fat accumulation was represented by a high pixel value. Three different deep-learning models, including CycleGAN were combined in the proposed method to generate PFCIs from CXRs. A single CycleGAN-based model was used to generate PFCIs from CXRs for comparison with the proposed method. To evaluate the image quality of the generated PFCIs, structural similarity index measure (SSIM), mean squared error (MSE), and mean absolute error (MAE) of (i) the PFCI generated using the proposed method and (ii) the PFCI generated using the single model were compared. RESULTS: The mean SSIM, MSE, and MAE were 8.56 × 10-1, 1.28 × 10-2, and 3.57 × 10-2, respectively, for the proposed model, and 7.62 × 10-1, 1.98 × 10-2, and 5.04 × 10-2, respectively, for the single CycleGAN-based model. CONCLUSION: PFCIs generated from CXRs with the proposed model showed better performance than those generated with the single model. The evaluation of PF without CT may be possible using the proposed method.
    2023年10月, Academic radiology, 英語, 国際誌
    研究論文（学術雑誌）

  • Aki Miyazaki, Kengo Ikejima, Mizuho Nishio, Minoru Yabuta, Hidetoshi Matsuo, Koji Onoue, Takaaki Matsunaga, Eiko Nishioka, Atsushi Kono, Daisuke Yamada, Ken Oba, Reiichi Ishikura, Takamichi Murakami
    To evaluate the diagnostic performance of our deep learning (DL) model of COVID-19 and investigate whether the diagnostic performance of radiologists was improved by referring to our model. Our datasets contained chest X-rays (CXRs) for the following three categories: normal (NORMAL), non-COVID-19 pneumonia (PNEUMONIA), and COVID-19 pneumonia (COVID). We used two public datasets and private dataset collected from eight hospitals for the development and external validation of our DL model (26,393 CXRs). Eight radiologists performed two reading sessions: one session was performed with reference to CXRs only, and the other was performed with reference to both CXRs and the results of the DL model. The evaluation metrics for the reading session were accuracy, sensitivity, specificity, and area under the curve (AUC). The accuracy of our DL model was 0.733, and that of the eight radiologists without DL was 0.696 ± 0.031. There was a significant difference in AUC between the radiologists with and without DL for COVID versus NORMAL or PNEUMONIA (p = 0.0038). Our DL model alone showed better diagnostic performance than that of most radiologists. In addition, our model significantly improved the diagnostic performance of radiologists for COVID versus NORMAL or PNEUMONIA.
    2023年10月, Scientific reports, 13(1) (1), 17533 - 17533, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 岡田 卓也, 佐々木 康二, 岡本 雄太郎, 松代 啓吾, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2023年10月, 日本インターベンショナルラジオロジー学会雑誌, 38(1) (1), 16 - 23, 日本語

  • Tianyuan Wang, Keitaro Sofue, Ryuji Shimada, Takeaki Ishihara, Ryuichi Yada, Masanori Miyamoto, Ryohei Sasaki, Takamichi Murakami
    To develop and investigate the feasibility of sub-second temporal resolution volumetric T1-weighted four-dimensional (4D-) MRI in comparison with 4D-CT for respiratory-correlated motion assessment using an MRI/CT-compatible phantom. Sub-second high temporal resolution (0.5 s) gradient-echo T1-weighted 4D-MRI was developed using a volumetric acquisition scheme with compressed sensing. An MRI/CT-compatible motion phantom (simulated liver tumor) with three sinusoidal movements of amplitudes and two respiratory patterns was introduced and imaged with 4D-MRI and 4D-CT to investigate the geometric accuracy of the target movement. The geometric accuracy, including centroid position, volume, similarity index of dice similarity coefficient (DSC), and Hausdorff distance (HD), was systematically evaluated. Proposed 4D-MRI achieved a similar geometric accuracy compared with 4D-CT regarding the centroid position, volume, and similarity index. The observed position differences of the absolute average centroid were within 0.08 cm in 4D-MRI and 0.03 cm in 4D-CT, less than the 1-pixel resolution for each modality. The observed volume difference in 4D-MRI/4D-CT was within 0.73 cm3 (4.5%)/0.29 cm3 (2.1%) for a large target and 0.06 cm3 (11.3%)/0.04 cm3 (11.6%) for a small target. The observed DSC values for 4D-MRI/4D-CT were at least 0.93/0.95 for the large target and 0.83/0.84 for the small target. The maximum HD values were 0.25 cm/0.31 cm for the large target and 0.21 cm/0.15 cm for the small target. Although 4D-CT potentially exhibit superior numerical accuracy in phantom studies, the proposed high temporal resolution 4D-MRI demonstrates sub-millimetre geometric accuracy comparable to that of 4D-CT. These findings suggest that the 4D-MRI technique is a viable option for characterizing motion and generating phase-dependent internal target volumes within the realm of radiotherapy.
    2023年09月, Scientific reports, 13(1) (1), 15685 - 15685, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Shintaro Ichikawa, Utaroh Motosugi, Yoshiyuki Sawai, Hisashi Ishida, Yasuharu Imai, Kazuto Kozaka, Masakatsu Tsurusaki, Keitaro Sofue, Takamichi Murakami, Nobuyuki Kawai, Masayuki Matsuo, Yoshihiko Fukukura, Seiichi Mawatari, Tatsuya Shimizu, Hiroyuki Morisaka, Taisuke Inoue, Satoshi Goshima
    AIM: To determine risk factors associated with hepatocellular carcinoma (HCC) development following direct-acting antiviral (DAA) therapy. METHODS: We enrolled patients with chronic hepatitis C who underwent direct-acting antiviral therapy and achieved sustained virologic response at 12 weeks between 2012 and 2018. Subsequently, patients were followed up. The primary endpoint was the development of HCC or the date of the last follow up when the absence of HCC was confirmed. Uni- and multivariate Cox proportional hazards models were used to identify factors contributing to HCC development, including gadoxetic acid-enhanced magnetic resonance imaging findings. The cumulative incidence rates of HCC development were calculated using the Kaplan-Meier method, and differences between groups were assessed using the log-rank test. RESULTS: The final study cohort comprised 482 patients (median age 70.5 years; 242 men). The median follow-up period was 36.8 months. Among 482 patients, 96 developed HCC (19.9%). The 1-, 3-, and 5-year cumulative rates of HCC development were 4.9%, 18.6%, and 30.5%, respectively. Multivariate analysis revealed that age, male sex, history of HCC, and hepatobiliary phase hypointense nodules without arterial phase hyperenhancement were independent risk factors significantly associated with HCC development (p < 0.001-0.04). The highest risk group included patients with both a history of HCC and the presence of hepatobiliary phase hypointense nodules without arterial phase hyperenhancement (the 1- and 3-year cumulative HCC development rates were 14.2% and 62.2%, respectively). CONCLUSION: History of HCC and presence of hepatobiliary phase hypointense nodules without arterial phase hyperenhancement were strong risk factors for HCC development following direct-acting antiviral therapy.
    2023年09月, Hepatology research : the official journal of the Japan Society of Hepatology, 英語, 国際誌
    研究論文（学術雑誌）

  • Akira Yamamoto, Tsutomu Tamada, Atsushi Higaki, Yuki Arita, Yoshiko Ueno, Takamichi Murakami, Masahiro Jinzaki
    Abstract Objectives To ascertain the clinical behaviors of unclassified renal cell carcinoma (RCC) and its characteristic imaging findings on CT and MRI. Methods Subjects in this retrospective study were 10 patients who had received a histological diagnosis of unclassified RCC based on World Health Organization (WHO) 2022 and who had undergone CT and/or MRI prior to surgery. In terms of clinical behaviors, TNM classification, stage, postoperative recurrence, time to recurrence, and postoperative survival were evaluated. In terms of imaging findings, tumor size, growth pattern, CT density, dynamic contrast-enhancement (DCE) pattern, internal appearance, presence of a pseudocapsule, and signal intensity on MRI were evaluated. We compared clinical behaviors and imaging findings, and investigated associations between them. Results One patient could not be followed-up due to death from other causes. Postoperative recurrence was observed in 4 patients, all of whom had Stage 3 RCC. In the remaining 5 patients without recurrence, all 5 patients showed Stage 2 or below. On imaging, unclassified RCC tended to be large (58.7 mm) and solid (100%), and heterogeneous interiors (80%), cystic degeneration (80%) and high intensity on diffusion-weighted imaging (DWI) (71.4%) were common. Comparing patients with and without recurrence, the following findings tended to differ between recurrence and recurrence-free groups: tumor size (73.4 ± 33.9 mm vs. 50.2 ± 33.9 mm, P = 0.286), growth pattern (invasive: 100% vs. 0%, expansive: 0% vs. 100%, P = 0.008 each), DCE pattern (progressive enhancement pattern, 66.7% vs. 0%, washout pattern, 0% vs. 66.7%, P = 0.135 each) and presence of a pseudocapsule (25% vs. 80%, P = 0.167). Conclusion The clinical behavior of unclassified RCC varies widely. Although imaging findings are also variable, findings of large, heterogeneous tumors with cystic degeneration and high intensity on DWI were common. Several imaging findings such as large size, invasive growth, progressive enhancement pattern and no pseudocapsule may enable prediction of prognosis in unclassified RCC.
    Springer Science and Business Media LLC, 2023年08月, Japanese Journal of Radiology
    研究論文（学術雑誌）

  • Hiroko Iijima, Masatoshi Kudo, Shoji Kubo, Masayuki Kurosaki, Michiie Sakamoto, Shuichiro Shiina, Ryosuke Tateishi, Osamu Nakashima, Takumi Fukumoto, Yutaka Matsuyama, Takamichi Murakami, Arata Takahashi, Hiroaki Miyata, Norihiro Kokudo
    In the 23rd Nationwide Follow-up Survey of Primary Liver Cancer in Japan, data from 20,889 newly registered patients and 42,274 previously registered follow-up patients were compiled from 516 institutions over a 2-year period from 1 January 2014 to 31 December 2015. Basic statistics compiled for patients newly registered in the 23rd survey was cause of death, past medical history, clinical diagnosis, imaging diagnosis, treatment-related factors, pathological diagnosis, recurrence status, and autopsy findings. Compared with the previous 22nd survey, the population of patients with hepatocellular carcinoma (HCC) was older at the time of clinical diagnosis, had more female patients, had more patients with non-B non-C HCC, had smaller tumor diameter, and was more frequently treated with hepatectomy. Cumulative survival rates were calculated for HCC, intrahepatic cholangiocarcinoma (ICC), and combined hepatocellular cholangiocarcinoma (combined HCC and ICC) by treatment type and background characteristics for patients newly registered between 2004 and 2015 whose final outcome was survival or death. Median overall survival and cumulative survival rates for HCC were calculated by dividing patients by combinations of background factors (number of tumors, tumor diameter, Child-Pugh grade, or ALBI grade) and by treatment type (hepatectomy, radiofrequency ablation therapy [RFA], transcatheter arterial chemoembolization [TACE], hepatic arterial infusion chemotherapy [HAIC] and systemic therapy). The same values were also calculated according to registration date by dividing patients newly registered between 1978 and 2015 into five time period groups. The data obtained from this nationwide follow-up survey are expected to contribute to advancing clinical research and treatment of primary liver cancer in the world. This article is protected by copyright. All rights reserved.
    2023年08月, Hepatology research : the official journal of the Japan Society of Hepatology, 53(10) (10), 895 - 959, 英語, 国際誌
    研究論文（学術雑誌）

  • 飯島 尋子, 工藤 正俊, 久保 正二, 黒崎 雅之, 坂元 亨宇, 椎名 秀一朗, 建石 良介, 中島 収, 福本 巧, 松山 裕, 村上 卓道, 國土 典宏, 高橋 新, 宮田 裕章, 田村 利恵, 上妻 智子, 日本肝癌研究会追跡調査委員会
    第23回全国原発性肝癌追跡調査においては,516施設から2014年1月1日から2015年12月31日までの2年間の20,889例の新規症例と42,274例の追跡症例が集計された.基礎統計は,第23回新規登録症例を対象として死因,既往歴,臨床診断,画像診断,治療法別の各因子,病理診断,再発,剖検についてまとめた.第22回調査と比較し,肝細胞癌における臨床診断時の高齢化,女性の増加,非B非C肝癌の増加,腫瘍径の縮小の傾向が,治療においては切除の割合の増加,局所療法におけるラジオ波焼灼療法の増加が認められた.2002年から2015年までの新規登録症例の中で最終予後が生存または死亡となった症例(不明を除く)について肝細胞癌,肝内胆管癌,混合型肝癌の治療法別,背景因子別生存中央値・累積生存率を算出した.肝細胞癌については腫瘍個数,腫瘍径,肝障害度,Child-Pugh分類を組み合わせることにより背景因子を揃えて,治療法別(肝切除,局所療法,肝動脈塞栓療法(TACE)),肝動注化学療法,全身薬物療法(分子標的治療)の累積生存率を算出し,また,1978年から2015年までの新規登録症例を5期に分け,累積生存率を算出した.新規登録症例数は経時的に増加し,肝細胞癌,肝内胆管癌,混合型肝癌ともに予後の改善が著しいことが明らかとなった.本追跡調査が原発性肝癌の研究および診療の進歩に役立つことを期待する.(著者抄録)
    (一社)日本肝臓学会, 2023年08月, 肝臓, 64(8) (8), 333 - 381, 日本語

  • Eisuke Ueshima, Keitaro Sofue, Haruyuki Takaki, Yutaka Hirata, Hiroshi Kodama, Takuya Okada, Masato Yamaguchi, Koichiro Yamakado, Takamichi Murakami
    PURPOSE: This study aimed to investigate the impact of transarterial embolization (TAE) on macrophage polarization and the modulatory effect of lenvatinib in combination with TAE in a rat hepatocellular carcinoma model. MATERIALS AND METHODS: A rat N1S1-bearing orthotopic model was subjected to TAE and administered 5 mg/kg of lenvatinib. CD8+, CD68+, and CD206+ cells were examined in four cohorts: sham (n=5), lenvatinib (n=5), TAE (n=5), and a combination of TAE and lenvatinib (n=5). Transcriptome analysis was performed to assess gene expression related to macrophage polarization in the sham, TAE, and combination groups. An in vitro co-culture experiment with bone marrow-derived macrophages was performed to identify lenvatinib target in macrophage polarization. RESULTS: There were no significant differences in the number of CD8+ and CD68+ cells among the four groups. Tumor-associated macrophage positivity for CD206 was significantly higher in the TAE group (58.1 ± 20.9) than in the sham (11.2 ± 14.3, P < 0.001) and combination (27.1 ± 19.7, P = 0.003) groups. In the transcriptome analysis, compared with those in the sham group, five macrophage polarization-related genes, including St6gal1, were upregulated by more than 1.5-fold in the TAE group and downregulated by more than 1.5-fold in the combination group. The co-culture experiment showed that lenvatinib did not affect macrophages but N1S1 cells, leading to macrophage polarization. CONCLUSION: TAE induced M2 macrophage polarization. Lenvatinib administration with TAE could reprogram macrophage polarization, improving tumor immune microenvironment.
    2023年07月, Journal of vascular and interventional radiology : JVIR, 英語, 国際誌
    研究論文（学術雑誌）

  • Bachir Taouli, Ahmed Ba-Ssalamah, Julius Chapiro, Jagpreet Chhatwal, Kathryn Fowler, Tae Wook Kang, Gesine Knobloch, Dow-Mu Koh, Masatoshi Kudo, Jeong Min Lee, Takamichi Murakami, David J Pinato, Kristina I Ringe, Bin Song, Parissa Tabrizian, Jin Wang, Jeong Hee Yoon, Mengsu Zeng, Jian Zhou, Valérie Vilgrain
    The 10th Global Forum for Liver Magnetic Resonance Imaging was held in October 2021. The themes of the presentations and discussions at this Forum are described in detail in the review by Taouli et al (2023). The focus of this second manuscript developed from the Forum is on multidisciplinary tumor board perspectives in hepatocellular carcinoma (HCC) management: how to approach early-, mid-, and late-stage management from the perspectives of a liver surgeon, an interventional radiologist, and an oncologist. The manuscript also includes a panel discussion by multidisciplinary experts on three selected cases that explore challenging aspects of HCC management. CLINICAL RELEVANCE STATEMENT: This review highlights the importance of a multidisciplinary team approach in liver cancer patients and includes the perspectives of a liver surgeon, an interventional radiologist, and an oncologist, including illustrative case studies. KEY POINTS: • A liver surgeon, interventional radiologist, and oncologist presented their perspectives on the treatment of early-, mid-, and late-stage HCC. • Different perspectives on HCC management between specialties emphasize the importance of multidisciplinary tumor boards. • A multidisciplinary faculty discussed challenging aspects of HCC management, as highlighted by three case studies.
    2023年07月, European radiology, 英語, 国際誌
    研究論文（学術雑誌）

  • Feiya Zeng, Feibi Zeng, Naoki Sugiyama, Munenobu Nogami, Takamichi Murakami
    Metastatic rectal cancer is rare and difficult to differentiate from primary rectal cancer. A 79-year-old man with a rectal mass detected by CT during postoperative follow-up of gastric cancer underwent 18F-FDG PET/MRI. Fused PET/MRI images revealed a lower FDG uptake within the mass, which appeared to surround the outside of the rectum, than in the rectal wall, suggesting rectal dissemination of gastric cancer. PET/MRI was useful for differentiating between mass and rectal wall uptake, because of the high contrast resolution of MRI and precise image fusion made possible by simultaneous image acquisition.
    2023年07月, Clinical nuclear medicine, 英語, 国際誌
    研究論文（学術雑誌）

  • Junko Inoue Inukai, Munenobu Nogami, Miho Tachibana, Feibi Zeng, Tatsuya Nishitani, Kazuhiro Kubo, Takamichi Murakami
    This study evaluated the diagnostic value of a rapid whole-body fluorodeoxyglucose (FDG) positron emission tomography (PET)/magnetic resonance imaging (MRI) approach, combining Bayesian penalised likelihood (BPL) PET with an optimised β value and abbreviated MRI (abb-MRI). The study compares the diagnostic performance of this approach with the standard PET/MRI that utilises ordered subsets expectation maximisation (OSEM) PET and standard MRI (std-MRI). The optimal β value was determined by evaluating the noise-equivalent count (NEC) phantom, background variability, contrast recovery, recovery coefficient, and visual scores (VS) for OSEM and BPL with β100–1000 at 2.5-, 1.5-, and 1.0-min scans, respectively. Clinical evaluations were conducted for NECpatient, NECdensity, liver signal-to-noise ratio (SNR), lesion maximum standardised uptake value, lesion signal-to-background ratio, lesion SNR, and VS in 49 patients. The diagnostic performance of BPL/abb-MRI was retrospectively assessed for lesion detection and differentiation in 156 patients using VS. The optimal β values were β600 for a 1.5-min scan and β700 for a 1.0-min scan. BPL/abb-MRI at these β values was equivalent to OSEM/std-MRI for a 2.5-min scan. By combining BPL with optimal β and abb-MRI, rapid whole-body PET/MRI could be achieved in ≤1.5 min per bed position, while maintaining comparable diagnostic performance to standard PET/MRI.
    MDPI AG, 2023年05月, Diagnostics, 13(11) (11), 1871 - 1871, 英語
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Munenobu Nogami, Tetsuya Tsujikawa, Hiroyuki Maeda, Nobuyuki Kosaka, Mizuho Takahashi, Naoki Kinoshita, Tetsuya Mori, Akira Makino, Yasushi Kiyono, Takamichi Murakami, Takanori Goi, Hidehiko Okazawa
    Coronavirus disease (COVID-19) vaccination is known to cause a diagnostic dilemma due to false-positive findings on [18F]FDG PET in vaccine-associated hypermetabolic lymphadenopathy. We present two case reports of women with estrogen-receptor (ER)-positive cancer of the breast who were vaccinated for COVID-19 in the deltoid muscle. [18F]FDG positron emission tomography (PET) demonstrated primary breast cancer and multiple axillary lymph nodes with increased [18F]FDG uptake, diagnosed as vaccine-associated [18F]FDG-avid lymph nodes. Subsequent [18F]FES PET revealed single axillary lymph node metastasis in the vaccine-associated [18F]FDG-avid lymph nodes. To the best of our knowledge, this is the first study showing the usefulness of [18F]FES PET in diagnosing axillary lymph node metastasis in COVID-19-vaccinated patients harboring ER-positive breast cancer. Thus, [18F]FES PET has potential applications in the detection of true-positive metastatic lymph nodes in patients with ER-positive breast cancer regardless of the ipsilateral or contralateral side, who have received COVID-19 vaccination.
    2023年05月, Diagnostics (Basel, Switzerland), 13(11) (11), 英語, 国際誌
    神戸大学リポジトリ（Kernel）へのリンク

  • Ryuji SHIMADA, Keitaro SOFUE, Yu UEDA, Shintaro HORII, Yoshiko UENO, Yuichiro SOMIYA, Akiko KUSAKA, Takamichi MURAKAMI
    Japanese Society for Magnetic Resonance in Medicine, 2023年05月, Japanese Journal of Magnetic Resonance in Medicine, 43(2) (2), 76 - 78
    研究論文（学術雑誌）

  • 佐々木 康二, 岡田 卓也, 松永 直樹, 松代 啓吾, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2023年05月, 日本インターベンショナルラジオロジー学会雑誌, 37(2) (2), 110 - 116, 日本語

  • Eiko Nishioka, Keitaro Sofue, Koji Maruyama, Eisuke Ueshima, Yoshiko Ueno, Masakatsu Tsurusaki, Shohei Komatsu, Takumi Fukumoto, Takamichi Murakami
    To assess the value of nonenhancing capsule by adding to enhancing capsule in gadoxetic acid-enhanced MRI (EOB-MRI) in comparison with contrast-enhanced CT (CE-CT) for diagnosing histological capsule in hepatocellular carcinoma (HCC). One-hundred fifty-one patients with HCC who underwent both CE-CT and EOB-MRI were retrospectively reviewed. Liver Imaging-Reporting and Data System (LI-RADS) v2018 imaging features, including enhancing and nonenhancing capsule were evaluated by two readers in CE-CT and EOB-MRI. Frequencies of each imaging feature were compared between CE-CT and EOB-MRI. The area under the receiver operating characteristic (AUC) curve for the diagnosis of histological capsule was compared across the following three imaging criteria: (1) enhancing capsule in CE-CT, (2) enhancing capsule in EOB-MRI, and (3) enhancing/nonenhancing capsule in EOB-MRI. Enhancing capsule in EOB-MRI was significantly less frequently depicted than that in CE-CT (p < 0.001 and = 0.016 for reader 1 and 2). Enhancing/nonenhancing capsule in EOB-MRI achieved a similar frequency of enhancing in CE-CT (p = 0.590 and 0.465 for reader 1 and 2). Adding nonenhancing capsule to enhancing capsule in EOB-MRI significantly increased AUCs (p < 0.001 for both readers) and achieved similar AUCs compared with enhancing capsule in CE-CT (p = 0.470 and 0.666 for reader 1 and 2). Adding nonenhancing capsule to the definition of capsule appearance can improve the diagnosis of capsule in EOB-MRI for the diagnosis of histological capsule in HCC and decrease discordance of capsule appearance between EOB-MRI and CE-CT.
    2023年04月, Scientific reports, 13(1) (1), 6113 - 6113, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 急性期/亜急性期の下腿動脈血栓症に対する吸引療法(Aspiration therapy for acute and subacute thromboembolic occlusion of tibial or peroneal arteries)
    高橋 拓也, 川崎 竜太, 小出 裕, 高橋 真依, 山本 雄也, 谷 龍一郎, 末永 裕子, 中野 由美子, 野村 佳克, 村上 博久, 岡田 卓也, 山口 雅人, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2023年04月, 日本インターベンショナルラジオロジー学会雑誌, 38(Suppl.) (Suppl.), 166 - 166, 英語

  • 術前大動脈分枝塞栓術を併用したEVAR(EXCLUDER)の一年成績 多施設共同前向き研究(One-year results of EVAR(EXCLUDER) with side branch embolization: A prospective multicenter study)
    佐々木 康二, 山口 雅人, 元津 倫幸, 川崎 竜太, 堀之内 宏樹, 坂本 憲昭, 魚谷 健祐, 宮本 直和, 福田 哲也, 谷口 尚範, 森 岳樹, 上嶋 英介, 岡田 卓也, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2023年04月, 日本インターベンショナルラジオロジー学会雑誌, 38(Suppl.) (Suppl.), 175 - 175, 英語

  • 有痛性脊椎転移に対する経皮的椎体形成術の有効性に関与する因子の検討
    松代 啓吾, 岡田 卓也, 八幡 宥徳, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2023年04月, 日本インターベンショナルラジオロジー学会雑誌, 38(Suppl.) (Suppl.), 140 - 140, 日本語

  • 肥満は腸管内腔グルコース排泄を増強する
    森田 靖子, 坂口 一彦, 野上 宗伸, 曽 菲比, 西坂 まり華, 伊藤 潤, 金子 景弘, 末松 那都, 山田 倫子, 菅原 健二, 廣田 勇士, 村上 卓道, 小川 渉
    (一社)日本糖尿病学会, 2023年04月, 糖尿病, 66(Suppl.1) (Suppl.1), S - 247, 日本語

  • 術前大動脈分枝塞栓術を併用したEVAR(EXCLUDER)の一年成績 多施設共同前向き研究(One-year results of EVAR(EXCLUDER) with side branch embolization: A prospective multicenter study)
    佐々木 康二, 山口 雅人, 元津 倫幸, 川崎 竜太, 堀之内 宏樹, 坂本 憲昭, 魚谷 健祐, 宮本 直和, 福田 哲也, 谷口 尚範, 森 岳樹, 上嶋 英介, 岡田 卓也, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2023年04月, 日本インターベンショナルラジオロジー学会雑誌, 38(Suppl.) (Suppl.), 175 - 175, 英語

  • 肥満は腸管内腔グルコース排泄を増強する
    森田 靖子, 坂口 一彦, 野上 宗伸, 曽 菲比, 西坂 まり華, 伊藤 潤, 金子 景弘, 末松 那都, 山田 倫子, 菅原 健二, 廣田 勇士, 村上 卓道, 小川 渉
    (一社)日本糖尿病学会, 2023年04月, 糖尿病, 66(Suppl.1) (Suppl.1), S - 247, 日本語

  • Yushi Tsujita, Keitaro Sofue, Eisuke Ueshima, Yoshiko Ueno, Masatoshi Hori, Masakatsu Tsurusaki, Takamichi Murakami
    The incidence of hepatocellular carcinoma (HCC) is still on the rise in North America and Europe and is the second leading cause of cancer-related mortality. The treatment of HCC varies, with surgery and locoregional therapy (LRT) such as radiofrequency ablation and transcatheter arterial chemoembolization, and radiation therapy being the primary treatment. Currently, systemic therapy with molecular-targeted agents and immune checkpoint inhibitors (ICIs) is becoming a major treatment option for the unresectable HCC. As the HCC after LRT or systemic therapy often remains unchanged in size and shows loss of contrast effect in contrast-enhanced CT or MRI, the response evaluation criteria in solid tumors (RECIST) and World Health Organization criteria, which are usually used to evaluate the treatment response of solid tumors, are not appropriate for HCC. The modified RECIST (mRECIST) and the European Association for the Study of the Liver (EASL) criteria were developed for HCC, with a focus on viable lesions. The latest 2018 edition of the Liver Imaging Reporting and Data System (LI-RADS) also includes a section on the evaluation of treatment response. The cancer microenvironment influences the therapeutic efficacy of ICIs. Several studies have examined the utility of gadoxetic acid-enhanced MRI for predicting the pathological and molecular genetic patterns of HCC. In the future, it may be possible to stratify prognosis and predict treatment response prior to systemic therapy by using pre-treatment imaging findings.
    Japanese Society for Magnetic Resonance in Medicine, 2023年04月, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 22(2) (2), 209 - 220, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 曽 菲比, 野上 宗伸, 村上 卓道
    (株)Gakken, 2023年03月, 画像診断, 43(5) (5), 461 - 463, 日本語

  • 辻田 有志, 祖父江 慶太郎, 矢部 慎二, 村上 卓道
    肝線維化は慢性肝疾患の最大の予後因子であり,進行すると肝硬変に至るため,早期の診断と治療介入が非常に重要である.肝線維化診断のgold standardはいまだ肝生検ではあるが,侵襲性の高さや再現性の低さといった課題も多い.日常臨床では肝線維化の進行による辺縁の鈍化や凸凹不整などをしばしば目にするが,そのような形態学的な変化を定量的に評価する試みもある.画像検査による線維化の評価法としては,造影CTを用いて細胞外液容積(ECV)を定量する方法やMR elastography(MRE)により弾性率を測定する方法が一般的である.また,dual-energy CTや3D MRE,spin echo-echo planar imagingなど,新たな技術を用いたより精度の高い評価法も報告されている.近年,放射線診断学領域においてさまざまな分野で人工知能の臨床応用に期待が高まっている.肝線維化の定量的評価に関しても深層学習を用いた研究が散見されており,いずれも良好な結果が報告されている.(著者抄録)
    医歯薬出版(株), 2023年03月, 医学のあゆみ, 284(12) (12), 941 - 944, 日本語

  • 曽 菲比, 野上 宗伸, 村上 卓道
    (株)Gakken, 2023年03月, 画像診断, 43(5) (5), 461 - 463, 日本語

  • Shinji Yabe, Keitaro Sofue, Masatoshi Hori, Tomoki Maebayashi, Megumi Nishigaki, Yushi Tsujita, Takeru Yamaguchi, Eisuke Ueshima, Yoshiko Ueno, Takamichi Murakami
    PURPOSE: To investigate the added value of contrast enhancement boost (CE-boost) images in multiphasic contrast-enhanced CT (CE-CT) for diagnosing small (<20 mm) hypervascular hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This retrospective study included 69 patients (age, 74 ± 8 years; 52 men) with 70 hypervascular HCCs (<20 mm) who underwent multiphasic CE-CT (pre-contrast, late arterial phase [LAP], portal venous phase [PVP], and equilibrium phase). Two types of CE-boost images were generated by subtracting PVP from LAP (LA-PV) images and LAP from PVP (PV-LA) images to enhance the contrast effect of hepatic arterial and portal venous perfusion more selectively. Tumor-to-liver contrast-to-noise ratios (CNRs) in CE-boost images were compared with those in CE-CT images using the Wilcoxon signed-rank test. Two independent readers reviewed the imaging datasets: CE-CT alone and CE-CT with CE-boost images. The diagnostic performance of each dataset was compared using jackknife alternative free-response receiver operating characteristics (JAFROC-1). RESULTS: The tumor-to-liver CNRs in the LA-PV (6.4 ± 3.0) and PV-LA (-3.3 ± 2.1) images were greater than those in the LAP (3.2 ± 1.7) and PVP images (-1.1 ± 1.4) (p <.001 for both). The reader-averaged figures of merit were 0.751 for CE-CT alone and 0.807 for CE-CT with CE-boost images (p <.001). Sensitivities increased by adding CE-boost images for both readers (p <.001 and = 0.03), while positive predictive values were equivalent (p >.99). CONCLUSION: Adding CE-boost images to multiphasic CE-CT can improve the diagnostic accuracy and sensitivity for small hypervascular HCC by increasing the tumor-to-liver CNR.
    Elsevier BV, 2023年03月, European journal of radiology, 160, 110696 - 110696, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Kiyoshi Hasegawa, Nobuyuki Takemura, Tatsuya Yamashita, Takeyuki Watadani, Masaki Kaibori, Shoji Kubo, Mitsuo Shimada, Hiroaki Nagano, Etsuro Hatano, Hiroshi Aikata, Hiroko Iijima, Kazuomi Ueshima, Kazuyoshi Ohkawa, Takuya Genda, Kaoru Tsuchiya, Takuji Torimura, Masafumi Ikeda, Junji Furuse, Masaaki Akahane, Satoshi Kobayashi, Hideyuki Sakurai, Atsuya Takeda, Takamichi Murakami, Utaroh Motosugi, Yutaka Matsuyama, Masatoshi Kudo, Ryosuke Tateishi
    The 5th version of the Clinical Practice Guidelines for Hepatocellular Carcinoma was revised by the Japan Society of Hepatology, according to the methodology of evidence-based medicine and partly to the Grading of Recommendations Assessment, Development and Evaluation system, which was published in October 2021 in Japanese. In addition to surveillance-diagnostic and treatment algorithms, a new algorithm for systemic therapy has been created, as multiple drugs for hepatocellular carcinoma can be currently selected. Herein, new or revised algorithms and evidence on which the recommendations are based are described. This article is protected by copyright. All rights reserved.
    Wiley, 2023年02月, Hepatology research : the official journal of the Japan Society of Hepatology, 53(5) (5), 383 - 390, 英語, 国際誌
    研究論文（学術雑誌）

  • Yoshinari Asaoka, Ryosuke Tateishi, Yasuhide Yamada, Hiroko Iijima, Naoya Kato, Mitsuo Shimada, Etsuro Hatano, Takumi Fukumoto, Takamichi Murakami, Hirohisa Yano, Kengo Yoshimitsu, Masayuki Kurosaki, Michiie Sakamoto, Yutaka Matsuyama, Masatoshi Kudo, Norihiro Kokudo
    510 Background: Currently 6 regimens are available for advanced hepatocellular carcinoma (HCC) in Japan, including atezolizumab plus bevacizumab (AB), sorafenib (S), and lenvatinib (L) for first-line treatment and regorafenib (R), ramucirumab (RAM), and cabozantinib (C) for the second-line treatment. In real-world clinical practice, the number of combinations of treatment sequences is enormous. We have launched a nationwide registry of systemic therapy for HCC named Hepatoma Registry of Integrating and Aggregating Electric Health Records (HERITAGE). Methods: The HERITAGE is linked to the nationwide follow-up survey of the Japan Liver Cancer Association; cases treated with systemic therapy between 2015 and 2022 were included in the current study. Information on treatment efficacy and duration was collected and registered on each treatment regimen. Results: As of June 2022, 6,400 treatment lines (S 2,319, L 2559, AB 768, R 406, RAM 251, C 71) in 4,307 cases were enrolled. The response rates, disease control rates, and median treatment duration of each sequence of regimens are shown in the table. The 1st line regimen, S, L, and AB, were also used as the second and later lines in Japan and found as effective as if used as the 1st line treatment. Limitation: No adjustments for clinical conditions were performed. Conclusions: We have demonstrated the efficacy of various treatment sequences in a sufficient number of cases. Clinical trial information: UMIN000046567 . [Table: see text]
    American Society of Clinical Oncology (ASCO), 2023年02月, Journal of Clinical Oncology, 41(4_suppl) (4_suppl), 510 - 510
    研究論文（学術雑誌）

  • 元津 倫幸, 山口 雅人, 松代 啓吾, 佐々木 康二, 上嶋 英介, 岡田 卓也, 杉本 幸司, 村上 卓道, 中井 秀和, 山中 勝弘, 岡田 健次, 川崎 竜太
    (一社)日本インターベンショナルラジオロジー学会, 2023年02月, 日本インターベンショナルラジオロジー学会雑誌, 37(1) (1), 2 - 12, 日本語

  • Akiyo Fukutomi, Keitaro Sofue, Eisuke Ueshima, Noriyuki Negi, Yoshiko Ueno, Yushi Tsujita, Shinji Yabe, Takeru Yamaguchi, Ryuji Shimada, Akiko Kusaka, Masatoshi Hori, Takamichi Murakami
    OBJECTIVES: To investigate the effect of deep learning image reconstruction (DLIR) on the accuracy of iodine quantification and image quality of dual-energy CT (DECT) compared to that of other reconstruction algorithms in a phantom experiment and an abdominal clinical study. METHODS: An elliptical phantom with five different iodine concentrations (1-12 mgI/mL) was imaged five times with fast-kilovoltage-switching DECT for three target volume CT dose indexes. All images were reconstructed using filtered back-projection, iterative reconstruction (two levels), and DLIR algorithms. Measured and nominal iodine concentrations were compared among the algorithms. Contrast-enhanced CT of the abdomen with the same scanner was acquired in clinical patients. In arterial and portal venous phase images, iodine concentration, image noise, and coefficients of variation for four locations were retrospectively compared among the algorithms. One-way repeated-measures analyses of variance were used to evaluate differences in the iodine concentrations, standard deviations, coefficients of variation, and percentages of error among the algorithms. RESULTS: In the phantom study, the measured iodine concentrations were equivalent among the algorithms: within ± 8% of the nominal values, with root-mean-square deviations of 0.08-0.36 mgI/mL, regardless of radiation dose. In the clinical study (50 patients; 35 men; mean age, 68 ± 11 years), iodine concentrations were equivalent among the algorithms for each location (all p > .99). Image noise and coefficients of variation were lower with DLIR than with the other algorithms (all p < .01). CONCLUSIONS: The DLIR algorithm reduced image noise and variability of iodine concentration values compared with other reconstruction algorithms in the fast-kilovoltage-switching dual-energy CT. KEY POINTS: • In the phantom study, standard deviations and coefficients of variation in iodine quantification were lower on images with the deep learning image reconstruction algorithm than on those with other algorithms. • In the clinical study, iodine concentrations of measurement location in the upper abdomen were consistent across four reconstruction algorithms, while image noise and variability of iodine concentrations were lower on images with the deep learning image reconstruction algorithm.
    Springer Science and Business Media LLC, 2023年02月, European radiology, 33(2) (2), 1388 - 1399, 英語, 国際誌
    研究論文（学術雑誌）

  • 胸部PET/MRIの減弱補正 高速Zero-TE MRIを用いた深層学習によるノイズ除去および擬似CT生成
    野上 宗伸, 松尾 秀俊, 西尾 瑞穂, 立花 美保, 井上 純子, 曽 菲比, 久保 和広, 栗本 貴子, 村上 卓道
    (一社)日本核医学会, 2023年, 核医学, 60(Suppl.) (Suppl.), S184 - S184, 日本語

  • FDG-PET/CTで特徴的な所見を呈した異所性ACTH産生縦隔腫瘍とAspergillosisを合併した一例
    山中 智晴, 曽 菲比, 立花 美保, 井上 純子, 神保 直江, 野上 宗伸, 村上 卓道
    (一社)日本核医学会, 2023年, 核医学, 60(Suppl.) (Suppl.), S185 - S185, 日本語

  • BPL再構成による高速全身FDG PET/MRIの有用性 ファントムおよび臨床実験による至適β値決定
    井上 純子, 野上 宗伸, 立花 美保, 曽 菲比, 西谷 竜也, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2023年, 核医学, 60(Suppl.) (Suppl.), S206 - S206, 日本語

  • ZTE MRIから2.5次元法深層学習で生成した骨要素を含む減弱補正が胸部領域のSUVに与える影響
    立花 美保, 野上 宗伸, 松尾 秀俊, 西尾 瑞穂, 井上 純子, 曽 菲比, 栗本 貴子, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2023年, 核医学, 60(Suppl.) (Suppl.), S206 - S206, 日本語

  • 立花 美保, 野上 宗伸, 井上 純子, 曽 菲比, 栗本 貴子, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2023年, 核医学, 60(1) (1), 38 - 38, 日本語

  • 井上 純子, 野上 宗伸, 立花 美保, 曽 菲比, 久保 和広, 栗本 貴子, 辻川 哲也, 吉田 好雄, 岡沢 秀彦, 村上 卓道
    (一社)日本核医学会, 2023年, 核医学, 60(1) (1), 38 - 39, 日本語

  • FDG-PET/CTで特徴的な所見を呈した異所性ACTH産生縦隔腫瘍とAspergillosisを合併した一例
    山中 智晴, 曽 菲比, 立花 美保, 井上 純子, 神保 直江, 野上 宗伸, 村上 卓道
    (一社)日本核医学会, 2023年, 核医学, 60(Suppl.) (Suppl.), S185 - S185, 日本語

  • BPL再構成による高速全身FDG PET/MRIの有用性 ファントムおよび臨床実験による至適β値決定
    井上 純子, 野上 宗伸, 立花 美保, 曽 菲比, 西谷 竜也, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2023年, 核医学, 60(Suppl.) (Suppl.), S206 - S206, 日本語

  • 胸部PET/MRIの減弱補正 高速Zero-TE MRIを用いた深層学習によるノイズ除去および擬似CT生成
    野上 宗伸, 松尾 秀俊, 西尾 瑞穂, 立花 美保, 井上 純子, 曽 菲比, 久保 和広, 栗本 貴子, 村上 卓道
    (一社)日本核医学会, 2023年, 核医学, 60(Suppl.) (Suppl.), S184 - S184, 日本語

  • ZTE MRIから2.5次元法深層学習で生成した骨要素を含む減弱補正が胸部領域のSUVに与える影響
    立花 美保, 野上 宗伸, 松尾 秀俊, 西尾 瑞穂, 井上 純子, 曽 菲比, 栗本 貴子, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2023年, 核医学, 60(Suppl.) (Suppl.), S206 - S206, 日本語

  • Mizuho Nishio, Eiji Ota, Hidetoshi Matsuo, Takaaki Matsunaga, Aki Miyazaki, Takamichi Murakami
    PURPOSE: The purpose of this study is to compare two libraries dedicated to the Markov chain Monte Carlo method: pystan and numpyro. In the comparison, we mainly focused on the agreement of estimated latent parameters and the performance of sampling using the Markov chain Monte Carlo method in Bayesian item response theory (IRT). MATERIALS AND METHODS: Bayesian 1PL-IRT and 2PL-IRT were implemented with pystan and numpyro. Then, the Bayesian 1PL-IRT and 2PL-IRT were applied to two types of medical data obtained from a published article. The same prior distributions of latent parameters were used in both pystan and numpyro. Estimation results of latent parameters of 1PL-IRT and 2PL-IRT were compared between pystan and numpyro. Additionally, the computational cost of the Markov chain Monte Carlo method was compared between the two libraries. To evaluate the computational cost of IRT models, simulation data were generated from the medical data and numpyro. RESULTS: For all the combinations of IRT types (1PL-IRT or 2PL-IRT) and medical data types, the mean and standard deviation of the estimated latent parameters were in good agreement between pystan and numpyro. In most cases, the sampling time using the Markov chain Monte Carlo method was shorter in numpyro than that in pystan. When the large-sized simulation data were used, numpyro with a graphics processing unit was useful for reducing the sampling time. CONCLUSION: Numpyro and pystan were useful for applying the Bayesian 1PL-IRT and 2PL-IRT. Our results show that the two libraries yielded similar estimation result and that regarding to sampling time, the fastest libraries differed based on the dataset size.
    2023年, PeerJ. Computer science, 9, e1620, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Masakatsu Tsurusaki, Taku Kotera, Ryohei Kozuki, Atsushi Urase, Ayumi Hirayama, Keitaro Sofue, Takamichi Murakami
    The Japanese Society of Interventional Radiology, 2023年, Interventional Radiology, 英語
    研究論文（学術雑誌）

  • Mizuho Nishio, Daigo Kobayashi, Hidetoshi Matsuo, Yasuyo Urase, Eiko Nishioka, Takamichi Murakami
    PURPOSE: This study proposes a Bayesian multidimensional nominal response model (MD-NRM) to statistically analyze the nominal response of multiclass classifications. MATERIALS AND METHODS: First, for MD-NRM, we extended the conventional nominal response model to achieve stable convergence of the Bayesian nominal response model and utilized multidimensional ability parameters. We then applied MD-NRM to a 3-class classification problem, where radiologists visually evaluated chest X-ray images and selected their diagnosis from one of the three classes. The classification problem consisted of 150 cases, and each of the six radiologists selected their diagnosis based on a visual evaluation of the images. Consequently, 900 (= 150 × 6) nominal responses were obtained. In MD-NRM, we assumed that the responses were determined by the softmax function, the ability of radiologists, and the difficulty of images. In addition, we assumed that the multidimensional ability of one radiologist were represented by a 3 × 3 matrix. The latent parameters of the MD-NRM (ability parameters of radiologists and difficulty parameters of images) were estimated from the 900 responses. To implement Bayesian MD-NRM and estimate the latent parameters, a probabilistic programming language (Stan, version 2.21.0) was used. RESULTS: For all parameters, the Rhat values were less than 1.10. This indicates that the latent parameters of the MD-NRM converged successfully. CONCLUSION: The results show that it is possible to estimate the latent parameters (ability and difficulty parameters) of the MD-NRM using Stan. Our code for the implementation of the MD-NRM is available as open source.
    2022年12月, Japanese journal of radiology, 41(4) (4), 449 - 455, 英語, 国内誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Influence of metal implants on quantitative evaluation of bone single-photon emission computed tomography/computed tomography.
    Oe K, Zeng F, Niikura T, Fukui T, Sawauchi K, Matsumoto T, Nogami M, Murakami T, Kuroda R
    2022年11月, Journal of Clinical Medicine, 英語
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Osamu Aramaki, Tadatoshi Takayama, Yutaka Matsuyama, Shoji Kubo, Norihiro Kokudo, Masayuki Kurosaki, Takamichi Murakami, Shuichiro Shiina, Masatoshi Kudo, Michiie Sakamoto, Osamu Nakashima, Takumi Fukumoto, Hiroko Iijima, Susumu Eguchi, Yuji Soejima, Masatoshi Makuuchi
    AIM: Although Makuuchi's criteria are widely used to determine the cut-off for safe liver resection, there have been few reports of concrete data supporting their validity. Here, we verified the utility of Makuuchi's criteria by comparing the operative mortality rates associated with liver resection between hepatocellular carcinoma (HCC) patients meeting or exceeding the criteria. METHODS: A database was built using data from 15 597 patients treated between 2000 and 2007 for whom values for all three variables included in Makuuchi's criteria for liver resection (clinical ascites, serum bilirubin, and indocyanine green clearance) were available. The patients were divided into those fulfilling (n = 12 175) or exceeding (n = 3422) the criteria. The postoperative mortality (death for any reason within 30 days) and long-term survival were compared between the two groups. RESULTS: The operative mortality rate was significantly lower in patients meeting the criteria than in those exceeding the criteria (1.07% vs. 2.01%, respectively; p < 0.001). On multivariate analysis, exceeded the criteria was significantly associated with the risk for operative mortality (relative risk 2.08; 95% confidence interval (CI), 1.23-3.52; p = 0.007). Surgical indication meeting or exceeding the criteria was an independent factor for overall survival (hazard ratio 1.27; 95% CI, 1.18-1.36; p < 0.001). CONCLUSION: Makuuchi's criteria are suitable for determining the indication for resection of HCC due to the reduction in risk of operative mortality.
    Wiley, 2022年10月, Hepatology research : the official journal of the Japan Society of Hepatology, 53(2) (2), 127 - 134, 英語, 国際誌
    研究論文（学術雑誌）

  • Naoki Matsunaga, Takuya Okada, Yuko Ono, Keigo Matsushiro, Koji Sasaki, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Masato Yamaguchi, Koji Sugimoto, Takamichi Murakami
    Abstract Background Spinal fractures rarely cause hemothorax, and no treatment consensus has been reached. Conservative treatment is generally selected in cases without arterial injury, but there have been some reports of uncontrolled bleeding. Here we report a case of hemothorax caused by spinal fracture without arterial injury treated with transcatheter arterial embolization. Case presentation An 88-year-old Japanese woman with back pain was diagnosed with hemothorax due to bleeding from an unstable fracture of the tenth thoracic vertebra. Contrast-enhanced computed tomography revealed no obvious arterial injury. We performed transcatheter arterial embolization of the bilateral tenth intercostal arteries to prevent rebleeding. The hemothorax did not worsen until surgical spinal fixation 9 days post-transcatheter arterial embolization, and she was discharged 30 days after admission. Conclusion Transcatheter arterial embolization for hemothorax caused by spinal fractures without obvious arterial injury may be a useful bridge to spinal fixation.
    Springer Science and Business Media LLC, 2022年09月, Journal of Medical Case Reports, 16(1) (1)
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 多巣性の鈍的脾損傷に対して脾動脈本幹にバルーンカテーテルを留置し止血を試みた一例
    高橋 真依, 小出 裕, 田口 裕司, 高橋 拓也, 山本 雄也, 谷 龍一郎, 末永 裕子, 川崎 竜太, 山口 雅人, 村上 卓道
    (公社)日本医学放射線学会, 2022年09月, 日本医学放射線学会秋季臨床大会抄録集, 59回, S445 - S445, 日本語

  • 左冠動脈主幹部閉塞を伴う上行大動脈損傷の一例
    山本 雄也, 小出 裕, 川崎 竜太, 石原 諭, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, 2022年08月, 日本医学放射線学会秋季臨床大会抄録集, 58回, S477 - S477, 日本語

  • 【Intermediate stage HCCに対するTACE】TACEにおける腫瘍微小環境の変化と分子標的薬・免疫治療併用の意義
    上嶋 英介, 祖父江 慶太郎, 松代 啓吾, 佐々木 康二, 元津 倫幸, 岡田 卓也, 山口 雅人, 杉本 幸司, 村上 卓道
    腫瘍の微小環境は血管、線維芽細胞、免疫細胞、細胞外器質等の複数の細胞・構造から構成されている。肝細胞癌に対する経皮的動脈化学塞栓術(TACE)が腫瘍微小環境(血管新生、代謝ストレス、免疫逃避)に与える影響について概説した。TACEと分子標的薬(血管新生阻害薬の抗VEGF抗体、チロシンキナーゼ阻害薬)との併用効果、免疫療法(免疫チェックポイント阻害薬)との併用効果について述べた。
    (一社)日本インターベンショナルラジオロジー学会, 2022年08月, 日本インターベンショナルラジオロジー学会雑誌, 36(3) (3), 244 - 253, 日本語

  • 【肝疾患における画像診断の進歩-腹部超音波、CT、MRI-】CTを用いたびまん性肝疾患の診断と定量評価の可能性
    祖父江 慶太郎, 村上 卓道
    肝脂肪化や線維化の評価では肝生検による組織評価がゴールドスタンダードであるが、サンプリングエラーや病理診断医間の評価のばらつきが問題であり、合併症のリスクや侵襲性の高さから繰り返し実施することは困難である。近年、画像診断装置を用いた非侵襲的な定量的評価法が注目されている。一般に肝脂肪化・線維化の定量評価にはその精度の高さから超音波やMRIが用いられるが、超音波では検査者間の技術差や再現性の低さが問題となり、MRIでは検査コストの高さや長い検査時間による画質低下が弱点となる。CTは病変の検出・鑑別・病期診断を目的として最も頻繁に用いられる検査モダリティの1つであり、短時間・低コストで検査を行うことができ再現性も高いため、びまん性肝疾患の評価やフォローアップにおける利用価値について研究が進んでいる。本稿ではCTを用いたびまん性肝疾患の診断と定量評価について、肝脂肪化・肝線維化を対象にその可能性と限界点について述べる。(著者抄録)
    (株)医学出版, 2022年08月, 消化器内科, 4(8) (8), 63 - 68, 日本語

  • Timo A Auer, Keitaro Sofue, Eisuke Ueshima, Nina Rauer, Takeru Yamaguchi, Bernhard Gebauer, Bernd Hamm, Takamichi Murakami, Christian Althoff
    Informa UK Limited, 2022年08月, Journal of Hepatocellular Carcinoma, Volume 9, 695 - 705, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Shoji Kubo, Hiroji Shinkawa, Yoshinari Asaoka, Tatsuya Ioka, Hiroshi Igaki, Namiki Izumi, Takao Itoi, Michiaki Unno, Masayuki Ohtsuka, Takuji Okusaka, Masumi Kadoya, Masatoshi Kudo, Takashi Kumada, Norihiro Kokudo, Michiie Sakamoto, Yoshihiro Sakamoto, Hideyuki Sakurai, Tadatoshi Takayama, Osamu Nakashima, Yasushi Nagata, Etsuro Hatano, Kenichi Harada, Takamichi Murakami, Masakazu Yamamoto
    This paper presents the first version of clinical practice guidelines for intrahepatic cholangiocarcinoma (ICC) established by the Liver Cancer Study Group of Japan. These guidelines consist of 1 treatment algorithm, 5 background statements, 16 clinical questions, and 1 clinical topic, including etiology, staging, pathology, diagnosis, and treatments. Globally, a high incidence of ICC has been reported in East and Southeast Asian countries, and the incidence has been gradually increasing in Japan and also in Western countries. Reported risk factors for ICC include cirrhosis, hepatitis B/C, alcohol consumption, diabetes, obesity, smoking, nonalcoholic steatohepatitis, and liver fluke infestation, as well as biliary diseases, such as primary sclerosing cholangitis, hepatolithiasis, congenital cholangiectasis, and Caroli disease. Chemical risk factors include thorium-232, 1,2-dichloropropane, and dichloromethane. CA19-9 and CEA are recommended as tumor markers for early detection and diagnostic of ICC. Abdominal ultrasonography, CT, and MRI are effective imaging modalities for diagnosing ICC. If bile duct invasion is suspected, imaging modalities for examining the bile ducts may be useful. In unresectable cases, tumor biopsy should be considered when deemed necessary for the differential diagnosis and drug therapy selection. The mainstay of treatment for patients with Child-Pugh class A or B liver function is surgical resection and drug therapy. If the patient has no regional lymph node metastasis (LNM) and has a single tumor, resection is the treatment of choice. If both regional LNM and multiple tumors are present, drug therapy is the first treatment of choice. If the patient has either regional LNM or multiple tumors, resection or drug therapy is selected, depending on the extent of metastasis or the number of tumors. If distant metastasis is present, drug therapy is the treatment of choice. Percutaneous ablation therapy may be considered for patients who are ineligible for surgical resection or drug therapy due to decreased hepatic functional reserve or comorbidities. For unresectable ICC without extrahepatic metastasis, stereotactic radiotherapy (tumor size ≤5 cm) or particle radiotherapy (no size restriction) may be considered. ICC is generally not indicated for liver transplantation, and palliative care is recommended for patients with Child-Pugh class C liver function.
    S. Karger AG, 2022年07月, Liver cancer, 11(4) (4), 290 - 314, 英語, 国際誌
    研究論文（学術雑誌）

  • Hidetoshi Matsuo, Mizuho Nishio, Munenobu Nogami, Feibi Zeng, Takako Kurimoto, Sandeep Kaushik, Florian Wiesinger, Atsushi K Kono, Takamichi Murakami
    The integrated positron emission tomography/magnetic resonance imaging (PET/MRI) scanner simultaneously acquires metabolic information via PET and morphological information using MRI. However, attenuation correction, which is necessary for quantitative PET evaluation, is difficult as it requires the generation of attenuation-correction maps from MRI, which has no direct relationship with the gamma-ray attenuation information. MRI-based bone tissue segmentation is potentially available for attenuation correction in relatively rigid and fixed organs such as the head and pelvis regions. However, this is challenging for the chest region because of respiratory and cardiac motions in the chest, its anatomically complicated structure, and the thin bone cortex. We propose a new method using unsupervised generative attentional networks with adaptive layer-instance normalisation for image-to-image translation (U-GAT-IT), which specialised in unpaired image transformation based on attention maps for image transformation. We added the modality-independent neighbourhood descriptor (MIND) to the loss of U-GAT-IT to guarantee anatomical consistency in the image transformation between different domains. Our proposed method obtained a synthesised computed tomography of the chest. Experimental results showed that our method outperforms current approaches. The study findings suggest the possibility of synthesising clinically acceptable computed tomography images from chest MRI with minimal changes in anatomical structures without human annotation.
    Springer Science and Business Media LLC, 2022年06月, Scientific reports, 12(1) (1), 11090 - 11090, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 曽菲比, 野上宗伸, 村上卓道
    2022年06月, 臨床画像, 38(6) (6), 682 - 689

  • Shiho Yokoo, Feibi Zeng, Munenobu Nogami, Yoshiko R Ueno, Takamichi Murakami
    ABSTRACT: A 52-year-old woman with a rapidly growing uterine tumor suspected of uterine sarcoma underwent 18F-FDG PET/MRI, revealing a myometrial mass and an endometrial lesion, suggesting dual primary neoplasms. Based on the PET/MRI findings, we changed the intraoperative procedure to determine the necessity of pelvic lymphadenectomy. PET/MRI was useful in diagnosing and differentiating between 2 malignant neoplasms in the uterus compared with PET/CT, due to MRI's high contrast resolution and precise fusion due to the simultaneous acquisition.
    2022年06月, Clinical nuclear medicine, 47(6) (6), e452-e454, 英語, 国際誌
    研究論文（学術雑誌）

  • ラット肝細胞癌モデルにおける塞栓によるマクロファージの極性転換はレンバチニブによってリプログラムされ得る(Embolization Induced Macrophage Polarization can be Reprogrammed by Lenvatinib in Rat Hepatoma Model)
    Ueshima Eisuke, Sofue Keitaro, Takaki Haruyuki, Hirata Yutaka, Kodama Hiroshi, Hamada Mostafa, Matsushiro Keigo, Sasaki Koji, Gentsu Tomoyuki, Okada Takuya, Yamaguchi Masato, Yamakado Koichiro, Sugimoto Koji, Murakami Takamichi
    (一社)日本インターベンショナルラジオロジー学会, 2022年05月, 日本インターベンショナルラジオロジー学会雑誌, 37(Suppl.) (Suppl.), 238 - 238, 英語

  • エクスクルーダーによるEVAR前の予防的な大動脈側枝塞栓術 前向き多施設共同研究(Preemptive aortic side branch embolization before EVAR with EXCLUDER:A prospective multicenter study)
    Sasaki Koji, Yamaguchi Masato, Gentsu Tomoyuki, Kawasaki Ryota, Horinouchi Hiroki, Sakamoto Noriaki, Uotani Kensuke, Miyamoto Naokazu, Fukuda Tetsuya, Taniguchi Takanori, Mori Takeki, Ueshima Eisuke, Okada Takuya, Sugimoto Koji, Murakami Takamichi
    (一社)日本インターベンショナルラジオロジー学会, 2022年05月, 日本インターベンショナルラジオロジー学会雑誌, 37(Suppl.) (Suppl.), 271 - 271, 英語

  • ENDURANTによるEVAR前の大動脈側枝塞栓術の先取り 多施設共同プロスペクティブ研究(Preemptive aortic side branch embolization before EVAR with ENDURANT: A prospective multicenter study)
    Gentsu Tomoyuki, Yamaguchi Masato, Sasaki Koji, Kawasaki Ryota, Horinouchi Hiroki, Sakamoto Noriaki, Uotani Kensuke, Miyamoto Naokazu, Fukuda Tetsuya, Taniguchi Takanori, Mori Takeki, Ueshima Eisuke, Okada Takuya, Sugimoto Koji, Murakami Takamichi
    (一社)日本インターベンショナルラジオロジー学会, 2022年05月, 日本インターベンショナルラジオロジー学会雑誌, 37(Suppl.) (Suppl.), 212 - 212, 英語

  • Tsujita Y, Sofue K, Ueshima E, Ueno Y, Hori M, Murakami T
    Viral hepatitis was previously the most common cause of chronic liver disease. However, in recent years, nonalcoholic fatty liver disease (NAFLD) cases have been increasing, especially in developed countries. NAFLD is histologically characterized by fat, fibrosis, and inflammation in the liver, eventually leading to cirrhosis and hepatocellular carcinoma. Although biopsy is the gold standard for the assessment of the liver parenchyma, quantitative evaluation methods, such as ultrasound, CT, and MRI, have been reported to have good diagnostic performances. The quantification of liver fat, fibrosis, and inflammation is expected to be clinically useful in terms of the prognosis, early intervention, and treatment response for the management of NAFLD. The aim of this review was to discuss the basics and prospects of MRI-based tissue quantifications of the liver, mainly focusing on proton density fat fraction for the quantification of fat deposition, MR elastography for the quantification of fibrosis, and multifrequency MR elastography for the evaluation of inflammation.
    Japanese Society for Magnetic Resonance in Medicine, 2022年05月, Magn Reson Med Sci[Epub ahead of print], 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Nishio M, Kobayashi D, Nishioka E, Matsuo H, Urase Y, Onoue K, Ishikura R, Kitamura Y, Sakai E, Tomita M, Hamanaka A, Murakami T
    This retrospective study aimed to develop and validate a deep learning model for the classification of coronavirus disease-2019 (COVID-19) pneumonia, non-COVID-19 pneumonia, and the healthy using chest X-ray (CXR) images. One private and two public datasets of CXR images were included. The private dataset included CXR from six hospitals. A total of 14,258 and 11,253 CXR images were included in the 2 public datasets and 455 in the private dataset. A deep learning model based on EfficientNet with noisy student was constructed using the three datasets. The test set of 150 CXR images in the private dataset were evaluated by the deep learning model and six radiologists. Three-category classification accuracy and class-wise area under the curve (AUC) for each of the COVID-19 pneumonia, non-COVID-19 pneumonia, and healthy were calculated. Consensus of the six radiologists was used for calculating class-wise AUC. The three-category classification accuracy of our model was 0.8667, and those of the six radiologists ranged from 0.5667 to 0.7733. For our model and the consensus of the six radiologists, the class-wise AUC of the healthy, non-COVID-19 pneumonia, and COVID-19 pneumonia were 0.9912, 0.9492, and 0.9752 and 0.9656, 0.8654, and 0.8740, respectively. Difference of the class-wise AUC between our model and the consensus of the six radiologists was statistically significant for COVID-19 pneumonia (p value = 0.001334). Thus, an accurate model of deep learning for the three-category classification could be constructed; the diagnostic performance of our model was significantly better than that of the consensus interpretation by the six radiologists for COVID-19 pneumonia.
    2022年05月, Scientific Reports, 12(1) (1), 8214 - 8214, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Masatoshi Kudo, Masafumi Ikeda, Kazuomi Ueshima, Michiie Sakamoto, Shuichiro Shiina, Ryosuke Tateishi, Kazuhiro Nouso, Kiyoshi Hasegawa, Junji Furuse, Shiro Miyayama, Takamichi Murakami, Tatsuya Yamashita, Norihiro Kokudo
    Response Evaluation Criteria in Solid Tumors (RECIST) is inappropriate to assess the direct effects of treatment on hepatocellular carcinoma (HCC) by locoregional therapies, such as radiofrequency ablation or transarterial chemoembolization. Therefore, establishment of response evaluation criteria solely devoted to HCC is needed in clinical practice, as well as in clinical trials of HCC treatment, such as systemic therapies, which cause necrosis of the tumor. Response Evaluation Criteria in Cancer of the Liver (RECICL) was revised in 2021 by the Liver Cancer Study Group of Japan based on the 2019 version of RECICL, which was commonly used in Japan. The major revised points of the RECICL 2021 is inclusion of RECIST version 1.1 and modified RECIST as response evaluation criteria in systemic therapy for HCC. We hope this new treatment response criteria, RECICL, proposed by the Liver Cancer Study Group of Japan will benefit the HCC treatment response evaluation in the setting of daily clinical practice and clinical trials as well, not only in Japan, but also internationally.
    Wiley, 2022年04月, Hepatology research : the official journal of the Japan Society of Hepatology, 52(4) (4), 329 - 336, 英語, 国際誌
    研究論文（学術雑誌）

  • Hideto Ueki, Tomoaki Terakawa, Yoshiko Ueno, Keitaro Sofue, Shintaro Horii, Yasuyoshi Okamura, Yukari Bando, Takuto Hara, Junya Furukawa, Kenichi Harada, Nobuyuki Hinata, Yuzo Nakano, Takamichi Murakami, Masato Fujisawa
    OBJECTIVE: In renal cell carcinoma with inferior vena cava (IVC) thrombus, adhesion to, or invasion into, the IVC wall will often increase the level of surgical difficulty and even necessitate resection of the IVC. It will generally be difficult to perform an accurate preoperative assessment using the standard imaging modalities of contrast-enhanced computed tomography and standard magnetic resonance imaging (MRI). Cine MRI is an MRI sequence that captures motion to produce detailed information on both the anatomy and the dynamic motion. In the present study, we evaluated the accuracy of preoperative cine MRI for determining the need for IVC wall resection, with validation of the imaging findings according to the intraoperative findings. METHODS: A total of 15 patients who had undergone radical nephrectomy and tumor thrombectomy from May 2018 to April 2020 met the inclusion criteria. The primary outcome of interest was the need for IVC resection because of adhesion or invasion of a venous tumor thrombus. Cine MRI was used to evaluate the blood flow between the tumor thrombus and the IVC wall and the presence of tumor thrombus mobility during free respiration. The sensitivity and specificity were calculated for preoperative cine MRI for determining the need for IVC wall resection. The Fisher exact test was used to determine the association between intraoperative IVC wall resection and the cine MRI findings. Furthermore, receiver operating characteristic curves and the area under the curve were used to compare the accuracy of conventional MRI and cine MRI. RESULTS: Of the 15 patients, 8 (53.3%) had undergone IVC resection. We found that the absence of both dynamic blood flow and tumor thrombus mobility on cine MRI could reliably predict for IVC resection with 100% (95% confidence interval, 51.8%-100%) sensitivity and 85.7% (95% confidence interval, 42.1%-1.00%) specificity. The area under the receiver operating characteristic curve was 0.821 for conventional MRI and 0.929 for cine MRI. CONCLUSIONS: In the preoperative setting, cine MRI could be a helpful examination modality to predict for the need for IVC wall resection for patients with renal cell carcinoma with venous tumor thrombus.
    2022年03月, Journal of vascular surgery. Venous and lymphatic disorders, 10(4) (4), 908 - 915, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 深層学習を用いた肺結節の三次元CT画像の生成(Generation of Three-Dimensional CT Images of Lung Nodules using Deep Learning)
    Matsunaga Takaaki, Nishio Mizuho, Matsuo Hidetoshi, Miyazaki Aki, Kono Atsushi, Sakamoto Ryo, Muramatsu Chisako, Fujita Hiroshi, Murakami Takamichi
    (公社)日本医学放射線学会, 2022年03月, 日本医学放射線学会学術集会抄録集, 81回, S232 - S232, 英語

  • 急激に腎機能低下が進行する動脈硬化性腎動脈病変に対して経皮的腎動脈形成術(PTRA)を行った1例
    谷 龍一郎, 宮本 直和, 津田 成康, 田頭 達, 山田 愼一郎, 梅野 晃弘, 上月 瞭平, 難波 富美子, 大森 美佳, 足立 秀治, 粟野 孝次郎, 冨田 優, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2022年03月, 日本インターベンショナルラジオロジー学会雑誌, 36(2) (2), 196 - 196, 日本語

  • 大動脈置換術後の人工血管感染に対するCTガイド下ドレナージ術の経験
    小出 裕, 山本 雄也, 川崎 竜太, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2022年03月, 日本インターベンショナルラジオロジー学会雑誌, 36(2) (2), 199 - 199, 日本語

  • 空置術後の内腸骨動脈瘤に対して透視下上臀動脈直接穿刺併用にて塞栓し得た1例
    高橋 拓也, 魚谷 健祐, 濱中 章洋, 山崎 愉子, 松永 卓明, 高橋 真依, 岡崎 仁志, 久島 健之, 杉本 幸司, 村上 卓道
    症例は80歳代男性。主訴は突然の腹痛であった。造影CTで腹部大動脈瘤、両側総腸骨動脈瘤、両側内腸骨動脈瘤を認め、径73mm大の左総腸骨動脈瘤破裂と診断された。緊急でY-graft置換術を施行され、Y-graftの脚は左外腸骨動脈と右総腸骨動脈にそれぞれ吻合された。この際27mm大の左内腸骨動脈瘤を認めていたが、緊急手術であったため根部の結紮のみが行われた。7ヵ月後に右総腸骨動脈瘤と右内腸骨動脈瘤に対するステントグラフト内挿術および右内腸骨動脈のコイル塞栓術が施行された。グラフと置換術後3年で左内腸骨動脈の瘤径が拡大し、42mmに増大したため塞栓術が依頼された。空置術後で順行性のアクセスが不可能となった内腸骨動脈瘤に対して、側副路経由の経動脈アプローチに加えて仰臥位のまま透視下に上臀動脈を直接穿刺し、双方向アプローチにて内腸骨動脈瘤の塞栓術を行い成功した。
    (一社)日本インターベンショナルラジオロジー学会, 2022年03月, 日本インターベンショナルラジオロジー学会雑誌, 36(2) (2), 137 - 141, 日本語

  • 減量効果を期待できる薬剤の現状と未来 PET-MRI連続撮像法によるメトホルミン依存性腸管FDG排泄動態の解析
    森田 靖子, 野上 宗伸, 坂口 一彦, 伊藤 潤, 金子 景弘, 山田 倫子, 駒田 久子, 菅原 健二, 廣田 勇士, 村上 卓道, 小川 渉
    (一社)日本肥満学会, 2022年03月, 肥満研究, 27(Suppl.) (Suppl.), 166 - 166, 日本語

  • 新規PET-MRI撮像法の開発によるメトホルミンによる腸管FDG集積の解析
    伊藤 潤, 野上 宗伸, 坂口 一彦, 金子 景弘, 森田 靖子, 山田 倫子, 駒田 久子, 菅原 健二, 廣田 勇士, 村上 卓道, 小川 渉
    (一社)日本肥満学会, 2022年03月, 肥満研究, 27(Suppl.) (Suppl.), 334 - 334, 日本語

  • EVAR後の内腸骨動脈瘤をup-and-over techniqueを用いてExcluder IBEで治療した1例
    佐々木 康二, 岡田 卓也, 山口 雅人, 松代 啓吾, 元津 倫幸, 上嶋 英介, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2022年03月, 日本インターベンショナルラジオロジー学会雑誌, 36(2) (2), 194 - 194, 日本語

  • Yoshiko Ueno, Tsutomu Tamada, Keitaro Sofue, Takamichi Murakami
    For assessing a cancer treatment, and for detecting and characterizing cancer, Diffusion-weighted imaging (DWI) is commonly used. The key in DWI’s use extracranially has been due to the emergence of of high-gradient amplitude and multichannel coils, parallelimaging, and echo-planar imaging. The benefit has been fewer motion artefacts and high-quality prostate images.Recently, new techniques have been developed to improve the signal-to-noise ratio of DWI with fewer artefacts, allowing an increase in spatial resolution. For apparent diffusion coefficient quantification, non-Gaussian diffusion models have been proposed as additional tools for prostate cancer detection and evaluation of its aggressiveness. More recently, radiomics and machine learning for prostate magnetic resonance imaging have emerged as novel techniques for the non-invasive characterisation of prostate cancer. This review presents recent developments in prostate DWI and discusses its potential use in clinical practice.
    British Institute of Radiology, 2022年03月, The British Journal of Radiology, 95(1131) (1131)
    研究論文（学術雑誌）

  • 冠動脈CTにおける動き補正アルゴリズムに対する脈拍と不整脈の影響
    北川 薫, 香川 清澄, 福富 朗世, 根宜 典行, 河野 淳, 日下 亜起子, 村上 卓道
    (公社)日本放射線技術学会, 2022年03月, 日本放射線技術学会総会学術大会予稿集, 78回, 147 - 147, 日本語

  • Yoshiko Ueno, Tsutomu Tamada, Keitaro Sofue, Yasuyo Urase, Nobuyuki Hinata, Masato Fujisawa, Takamichi Murakami
    Background: Prostate apparent diffusion coefficient (ADC) values calculated from diffusion-weighted imaging have been used for evaluating prostate cancer (PCa) aggressiveness. However, the way of measuring ADC values has varied depending on the study. Purpose: To investigate inter- and intra-reader variability and diagnostic performance of three kinds of shaped 2D regions of interests (ROIs) for tumor ADC measurements in PCa. Material and Methods: Seventy-four patients with PCa undergoing 3-T MRI before surgery were included. Histologic findings from radical prostatectomy specimens were reviewed to define each patient's dominant tumor. Three readers independently measured the tumor ADCs using three different ROI methods: freehand, large-circle, and small-circles ROIs. Readers repeated measurements after 3 weeks. Bland-Altman analysis was performed to evaluate the inter- and intra-reader variability. Receiver Operating Characteristic analysis was used for assessment of tumor aggressiveness for PCa. Results: For intra-reader and inter-reader variability, the mean coefficient of repeatability for freehand ROIs, large-circle ROIs, and small-circles ROIs were as follows: 13.7%, 12.4%, and 11.5%; 9.4%, 9.7%, and 9.5%. For differentiating Gleason score (GS) = 3 + 3 from GS ≥ 3 + 4 tumors, the area under the curves were 0.90 for freehand ROIs, 0.89 for large-circle ROIs, and 0.94 small-circles ROIs (p = 0.31). Conclusion: The variations in ROI method did not have a major influence on intra-reader or inter-reader reproducibility or diagnostic performance for prostate ADC measurements.
    2022年03月, Acta radiologica open, 11(3) (3), 20584601221086500 - 20584601221086500, 英語, 国際誌
    研究論文（学術雑誌）

  • Keitaro Sofue, Eisuke Ueshima, Atsuhiro Masuda, Sachiyo Shirakawa, Yoh Zen, Yoshiko Ueno, Yushi Tsujita, Takeru Yamaguchi, Shinji Yabe, Takeshi Tanaka, Noriko Inomata, Hirochika Toyama, Takumi Fukumoto, Yuzo Kodama, Takamichi Murakami
    OBJECTIVE: To investigate the diagnostic performance of the extracellular volume (ECV) fraction in multiphasic contrast-enhanced computed tomography (CE-CT) for estimating histologic pancreatic fibrosis and predicting postoperative pancreatic fistula (POPF). METHODS: Eighty-five patients (49 men; mean age, 69 years) who underwent multiphasic CE-CT followed by pancreaticoduodenectomy with pancreaticojejunal anastomosis between January 2012 and December 2018 were retrospectively included. The ECV fraction was calculated from absolute enhancements of the pancreas and aorta between the precontrast and equilibrium-phase images, followed by comparisons among histologic pancreatic fibrosis grades (F0‒F3). The diagnostic performance of the ECV fraction in advanced fibrosis (F2‒F3) was evaluated using receiver operating characteristic curve analysis. Multivariate logistic regression analysis was used to evaluate the associations of the risk of POPF development with patient characteristics, histologic findings, and CT imaging parameters. RESULTS: The mean ECV fraction of the pancreas was 34.4% ± 9.5, with an excellent intrareader agreement of 0.811 and a moderate positive correlation with pancreatic fibrosis (r = 0.476; p < 0.001). The mean ECV fraction in advanced fibrosis was significantly higher than that in no/mild fibrosis (44.4% ± 10.8 vs. 31.7% ± 6.7; p < 0.001), and the area under the receiver operating characteristic curve for the diagnosis of advanced fibrosis was 0.837. Twenty-two patients (25.9%) developed clinically relevant POPF. Multivariate logistic regression analysis demonstrated that the ECV fraction was a significant predictor of POPF. CONCLUSIONS: The ECV fraction can offer quantitative information for assessing pancreatic fibrosis and POPF after pancreaticojejunal anastomosis. KEY POINTS: • There was a moderate positive correlation of the extracellular volume (ECV) fraction of the pancreas in contrast-enhanced CT with the histologic grade of pancreatic fibrosis (r = 0.476; p < 0.001). • The ECV fraction was higher in advanced fibrosis (F2‒F3) than in no/mild fibrosis (F0‒F1) (p < 0.001), with an AUC of 0.837 for detecting advanced fibrosis. • The ECV fraction was an independent risk factor for predicting subclinical (odds ratio, 0.81) and clinical (odds ratio, 0.80) postoperative pancreatic fistula.
    2022年03月, European radiology, 32(3) (3), 1770 - 1780, 英語, 国際誌
    研究論文（学術雑誌）

  • 123I-MIBGシンチグラフィで腎に異常集積を認めた腎動脈解離の1例
    杉山 朋加, 辻田 有志, 神田 知紀, 山口 尊, 矢部 慎二, 上嶋 英介, 上野 嘉子, 河野 淳, 祖父江 慶太郎, 野上 宗伸, 堀 雅敏, 村上 卓道
    (公社)日本医学放射線学会, 2022年02月, Japanese Journal of Radiology, 40(Suppl.) (Suppl.), 39 - 39, 日本語

  • 重安 奈央子, 佐々木 康二, 神田 知紀, 小松 正人, 村上 卓道
    60歳代女性。右下腿の疼痛を主訴に前医を受診し、MRIで仙骨の腫瘤を認められ、精査目的で当院に紹介された。CTで仙骨S3左外側部に溶骨性変化を認め、病変の辺縁に硬化性変化を認めた。MRIで同部にT1強調像で低信号、T2強調像で低信号～高信号が混在する領域を認め、脂肪抑制T2強調像では不均一な高信号を呈したが、T2強調像と比較すると信号低下を伴う領域を伴っており、脂肪の含有を伴っていると考えられた。画像所見からは悪性腫瘍の可能性が否定できず、経皮的CTガイド下骨腫瘍生検を行い、骨内褐色脂肪腫と診断した。
    金原出版(株), 2022年02月, 臨床放射線, 67(2) (2), 217 - 221, 日本語

  • 腹部骨盤領域の外傷IVR
    小出 裕, 川崎 竜太, 田口 裕司, 杉本 幸司, 村上 卓道
    (一社)日本腹部救急医学会, 2022年02月, 日本腹部救急医学会雑誌, 42(2) (2), 262 - 262, 日本語

  • 重安 奈央子, 佐々木 康二, 神田 知紀, 小松 正人, 村上 卓道
    金原出版(株), 2022年02月, 臨床放射線, 67(2) (2), 217 - 221, 日本語

  • Takeru Yamaguchi, Keitaro Sofue, Eisuke Ueshima, Yoshiko Ueno, Yushi Tsujita, Shinji Yabe, Sachiyo Shirakawa, Hirochika Toyama, Masatoshi Hori, Takumi Fukumoto, Takamichi Murakami
    Wiley, 2022年01月, Journal of Magnetic Resonance Imaging
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 犬養 純子, 野上 宗伸, 曽 菲比, 立花 美保, 久保 和広, 坂本 攝, 竹中 大祐, 村上 卓道
    (一社)日本核医学会, 2022年, 核医学, 59(1) (1), 35 - 35, 日本語

  • 曽 菲亜, 曽 菲比, 立花 美保, 犬養 純子, 久保 和広, 野上 宗伸, 村上 卓道
    (一社)日本核医学会, 2022年, 核医学, 59(1) (1), 37 - 37, 日本語

  • 立花 美保, 野上 宗伸, 松尾 秀俊, 西尾 瑞穂, 犬養 純子, 曽 菲比, 栗本 貴子, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2022年, 核医学, 59(1) (1), 35 - 35, 日本語

  • Timo A Auer, Keitaro Sofue, Eisuke Ueshima, Nina Rauer, Takeru Yamaguchi, Bernhard Gebauer, Bernd Hamm, Takamichi Murakami, Christian E Althoff
    OBJECTIVE: The purpose of this study was to investigate outcomes of transarterial chemoembolization (TACE) in treating hepatocellular carcinoma (HCC) comparing the different approaches used in Germany and Japan. METHODS: This binational IRB-approved retrospective dual-center study included a total of 94 HCC patients subdivided in a German and a Japanese cohort. For each patient, liver and tumor volumetry was performed using computed tomography (CT) and magnetic resonance imaging (MRI). Furthermore, a comprehensive risk profile, including body constitution and liver and kidney function was established. Primary endpoints were progression-free and overall survival (PFS/OS). RESULTS: PFS in the German cohort was 168 vs 224d in the Japanese cohort (p=0.640). When subdivided by BCLC stage, no significant differences were reported (p=0.160-0.429). OS was significantly longer in the Japanese cohort with 856 vs. 303d (p<0.001). OS for BCLC A was significantly longer in the Japanese cohort (1960 vs. 428d; p<0.001), while survival rates did not differ significantly in BCLC B (785 vs 330d; p=0.067) and C-stages (208 vs 302d; p=0.186). Older age (p=0.034), poorer liver/kidney function (p=0.025-0-035), and a higher liver/tumor ratio (p<0.001) were found to correlate with shorter survival. ECOG scores were significantly higher in the German cohort (p=0.002). CONCLUSION: While OS is longer in TACE-treated patients in the Japanese cohort compared to the German cohort, the two approaches seem to be equally effective as PFS does not differ significantly. The different survival rates may be caused by the different clinical performance status of the selected collectives. In very early and early stage HCC, TACE in Japan seems to be an effective treatment option while in Germany for patients in those stages TACE remains a second-line option for patients not available for surgery or ablation.
    2022年, Journal of hepatocellular carcinoma, 9, 695 - 705, 英語, 国際誌
    研究論文（学術雑誌）

  • 深層学習を用いてZTE MRIから生成した骨による減弱補正が胸部領域のSUVに及ぼす影響
    立花 美保, 野上 宗伸, 松尾 秀俊, 西尾 瑞穂, 犬養 純子, 曽 菲比, 栗本 貴子, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2022年, 核医学, 59(1) (1), 35 - 35, 日本語

  • Masatoshi Kudo, Namiki Izumi, Norihiro Kokudo, Michiie Sakamoto, Shuichiro Shiina, Tadatoshi Takayama, Ryosuke Tateishi, Osamu Nakashima, Takamichi Murakami, Yutaka Matsuyama, Arata Takahashi, Hiroaki Miyata, Shoji Kubo
    In the 22nd Nationwide Follow-up Survey of Primary Liver Cancer in Japan, data from 21 155 newly registered patients and 43 041 previously registered follow-up patients were compiled from 538 institutions over a 2-year period from January 1, 2012 to December 31, 2013. Basic statistics compiled for patients newly registered in the 22nd survey were cause of death, past medical history, clinical diagnosis, imaging diagnosis, treatment-related factors, pathologic diagnosis, recurrence status and autopsy findings. Compared with the previous 21st survey, the population of patients with hepatocellular carcinoma (HCC) was older at the time of clinical diagnosis, had more female patients, more patients with non-B non-C HCC, smaller tumor diameter and was more frequently treated with hepatectomy. Cumulative survival rates were calculated for HCC, intrahepatic cholangiocarcinoma, and combined hepatocellular cholangiocarcinoma (combined HCC and intrahepatic cholangiocarcinoma) by treatment type and background characteristics for patients newly registered between 2002 and 2013 whose final outcome was survival or death. Median overall survival and cumulative survival rates for HCC were calculated by dividing patients by combinations of background factors (number of tumors, tumor diameter or Child-Pugh grade) and by treatment type (hepatectomy, radiofrequency ablation therapy, transcatheter arterial chemoembolization, hepatic arterial infusion chemotherapy and systemic therapy). The same values were also calculated according to registration date by dividing patients newly registered between 1978 and 2013 into five time period groups. The data obtained from this nationwide follow-up survey are expected to contribute to advancing clinical research and treatment of primary liver cancer worldwide.
    Wiley, 2022年01月, Hepatology research : the official journal of the Japan Society of Hepatology, 52(1) (1), 5 - 66, 英語, 国際誌
    研究論文（学術雑誌）

  • 島田 隆史, 祖父江 慶太郎, 上田 優, 谷 和紀子, 吉田 直碁, 堀井 慎太郎, 曽宮 雄一郎, 上野 嘉子, 日下 亜起子, 村上 卓道
    産業開発機構(株), 2021年12月, 映像情報Medical, 53(14) (14), 106 - 113, 日本語

  • 慢性血栓塞栓性肺高血圧症患者における低侵襲・高精度な肺動脈平均圧の予測モデル作成
    吉井 隆浩, 松尾 秀俊, 高橋 真依, 西尾 瑞穂, 河野 淳, 谷口 悠, 平田 健一, 村上 卓道
    (一社)日本医療情報学会, 2021年11月, 医療情報学連合大会論文集, 41回, 1111 - 1114, 日本語

  • 大学病院における遺伝的アルゴリズムを用いた当直予定表作成システムの開発
    松尾 秀俊, 松永 卓明, 佐々木 康二, 岡田 卓也, 西尾 瑞穂, 河野 淳, 村上 卓道
    (一社)日本医療情報学会, 2021年11月, 医療情報学連合大会論文集, 41回, 1122 - 1124, 日本語

  • Tahara J, Nogami M, Inukai J, Tachibana M, Zeng F, Ueno Y, Murakami T
    2021年11月, Japanese Archive of cases conference of clinical nuclear medicine, 3, 9 - 17
    神戸大学リポジトリ（Kernel）へのリンク

  • Koji Sasaki, Takuya Okada, Masato Yamaguchi, Masashi Tajiri, Mostafa Ahmed, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Koji Sugimoto, Takamichi Murakami
    PURPOSE: The purpose is to investigate the major and minor complications of the pancreas after transcatheter arterial embolization (TAE) using n-butyl-2-cyanoacrylate (NBCA) for bleeding from pancreatic arteries. MATERIALS AND METHODS: Thirty-three patients who underwent TAE using NBCA for acute bleeding from pancreatic arteries and their parent arteries followed by contrast-enhanced computed tomography (CE-CT) were evaluated retrospectively. Complications and risk factors were assessed using Mann-Whitney U test or Fisher's exact test for the univariate analysis. Patients' characteristic, embolized artery, procedure details, and clinical outcomes were examined as possible risk factors. RESULTS: TAE was performed successfully in all patients. Minor pancreatic complications occurred in 10 patients (30%), including acute mild pancreatitis (n = 4) and focal lack of pancreatic parenchymal enhancement on CE-CT without pancreatitis (n = 6). No cases of major pancreatic complications, such as moderate/severe pancreatitis, were reported. Embolized artery was the only significant risk factor. The rate of complications per embolized artery were 15% (three out of 20 patients) in the arteries of the pancreatic head and 54% (seven out of 13 patients) in the arteries of pancreatic body and tail (p = 0.025). CONCLUSION: TAE using NBCA for acute bleeding from pancreatic arteries is efficacious and safe. Mild pancreatic complications were observed more frequently in case of embolization of the pancreatic body and tail region than the pancreatic head.
    Springer Science and Business Media LLC, 2021年10月, Japanese journal of radiology, 40(3) (3), 308 - 317, 英語, 国内誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 当院における内臓動脈瘤に対する血管内治療の経験
    山口 雅人, 松永 直樹, 佐々木 康二, 元津 倫幸, 岡田 卓也, 杉本 幸司, 村上 卓道
    (一社)日本脈管学会, 2021年10月, 脈管学, 61(Suppl.) (Suppl.), S149 - S149, 日本語

  • 【TACE再考】Intermediate stage肝癌において薬物治療とTACEは共存共栄
    工藤 正俊, 田中 正俊, 村上 卓道
    (株)アークメディア, 2021年09月, 肝胆膵, 83(3) (3), 343 - 362, 日本語

  • 杉山 朋加, 小路田 泰之, 神田 知紀, 横尾 紫穂, 宮崎 亜樹, 松尾 秀俊, 村上 卓道
    症例は50歳代女性で、家族が毛細血管拡張症と診断されたことを契機にCTが施行され、肺や肝臓に多発する動静脈奇形を認め、遺伝性出血性毛細血管拡張症(HHT)と診断された。受診日の朝より辻褄の合わない言動があり、精査加療目的に当院に紹介受診した。頭部単純CTでは、直静脈洞、ガレン大静脈および内大脳静脈の一部に高吸収域を認めた。頭部単純MRIにおけるT2強調像では単純CTでの高吸収域に一致した低信号域を認め、急性期の直静脈洞血栓が疑われた。上矢状静脈洞にはT1強調像およびFLAIR像で高信号域を認め、こちらも血栓を見ているものと考えられた。FLAIR像および拡散強調像では視床、尾状核頭、被殻に両側性の高信号域を認め、直静脈洞閉塞に伴う脳実質の浮腫性変化や梗塞を反映した所見と考えられた。この他、右前頭葉には既往の膿瘍後の変化を認め、小脳虫部右側には磁化率強調像にて静脈奇形を考える線状の低信号域が、両側淡蒼球には門脈大循環シャントによると思われるT1強調像で高信号域を認めた。受診当日にカテーテル血管造影検査を行い、直静脈洞、両側横静脈洞、上矢状静脈洞にそれぞれ血栓が認められたため、静脈血栓回収術を施行し抗凝固療法を開始した。治療により意識状態は改善傾向を示したが、自発性の低下や両側四肢の軽度麻痺などが残存したため、リハビリ目的に転院となった。その後のフォローにてHHTに伴う鼻出血が頻回となったため抗凝固薬療法を中止したが、脳静脈血栓症の再発なく経過している。
    金原出版(株), 2021年09月, 臨床放射線, 66(9) (9), 937 - 942, 日本語

  • 異なる受信コイルを用いた膝関節MRIにおけるコイル特性の検討
    石田 瑞穂, 曽宮 雄一郎, 吉田 直碁, 堀井 慎太郎, 島田 隆史, 河野 淳, 日下 亜起子, 村上 卓道
    (公社)日本放射線技術学会, 2021年09月, 日本放射線技術学会雑誌, 77(9) (9), 1034 - 1034, 日本語

  • Dual Energy CTにおけるDeep Learning Reconstructionがヨード検出に与える影響
    坂田 裕一郎, 福富 朗世, 根宜 典之, 香川 清澄, 前林 知樹, 日下 亜起子, 河野 淳, 村上 卓道
    (公社)日本放射線技術学会, 2021年09月, 日本放射線技術学会雑誌, 77(9) (9), 1074 - 1074, 日本語

  • 金属アーチファクト低減法と画像再構成法の組み合わせに関する検討
    石川 和希, 香川 清澄, 根宜 典行, 日下 亜起子, 河野 淳, 村上 卓道
    (公社)日本放射線技術学会, 2021年09月, 日本放射線技術学会雑誌, 77(9) (9), 1115 - 1115, 日本語

  • Kazuhiro Kitajima, Takako Kihara, Yusuke Kawanaka, Junko Takahama, Yoshiko Ueno, Takamichi Murakami, Kotaro Yoshida, Fumi Kato, Akiko Takahata, Yoshihiko Fukukura, Jiro Munechika, Yasunari Fujinaga, Takeru Fukunaga, Masahiro Tanabe, Yuichiro Kanie, Ayumu Kido, Tsutomu Tamada, Rika Yoshida, Yuki Kamishima, Koichiro Yamakado
    PURPOSE: This study aimed to examine MRI features and staging of neuroendocrine carcinoma (NEC) of the endometrium and evaluate survival. METHODS: Clinical data, pathological, and preoperative pelvic MRI findings in 22 patients with histologically surgery-proven endometrial NEC were retrospectively reviewed. Tumors were pure NEC (n = 10) or mixed histotype (n = 12), with 13 large and nine small cell type. RESULTS: International Federation of Gynecology and Obstetrics (FIGO) staging was I, II, III, and IV in 6, 2, 12, and 2 patients, respectively. In 13 (76.4%) of 17 patients with pathological deep myometrial invasion, MRI showed abnormal diffusely infiltrative high T2 signal intensity throughout the myometrium with loss of normal uterine architecture. All tumors had restricted diffusion (apparent diffusion coefficient map low signal intensity, diffusion weighted imaging high signal intensity). Accuracy of T staging by MRI for all cases was 81.8%, with reference to pathology staging, while patient-based sensitivity, specificity, and accuracy for detecting metastatic pelvic lymph nodes was 60.0%, 100%, and 77.8%, respectively. Two intrapelvic peritoneal dissemination cases were detected by MRI. During follow-up (mean 30.4, range 3.3-138.4 months), 16 patients (72.7%) experienced recurrence and 12 (54.5%) died of disease. Two-year disease-free and overall survival rates for FIGO I, II, III, and IV were 66.7% and 83.3%, 50% and 100%, 10% and 33.3%, and 0% and 0%, respectively. CONCLUSION: Abnormal diffusely infiltrative high T2 signal intensity throughout the myometrium with normal uterine architecture loss and obvious restricted diffusion throughout the tumor are suggestive features of endometrial NEC. Pelvic MRI is reliable for intrapelvic staging of affected patients.
    2021年09月, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 20(3) (3), 236 - 244, 英語, 国内誌
    研究論文（学術雑誌）

  • Takamichi Murakami, Keitaro Sofue, Masatoshi Hori
    Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA; Gadoxetic acid; Gadoxetate disodium) is a hepatocyte-specific MR contrast agent. It acts as an extracellular contrast agent in the early phase after intravenous injection, and then is taken up by hepatocytes later. Using this contrast agent, we can evaluate the hemodynamics of the liver and liver tumors, and can therefore improve the detection and characterization of hepatocellular carcinoma (HCC). Gd-EOB-DTPA helps in the more accurate detection of hypervascular HCC than by other agents. In addition, Gd-EOB-DTPA can detect hypovascular HCC, which is an early stage of the multi-stage carcinogenesis, with a low signal in the hepatobiliary phase. In addition to tumor detection and characterization, Gd-EOB-DTPA contrast-enhanced MR imaging can be applied for liver function evaluation and prognoses evaluation. Thus, Gd-EOB-DTPA plays an important role in the diagnosis of HCC. However, we have to employ optimal imaging techniques to improve the diagnostic ability. In this review, we aimed to discuss the characteristics of the contrast media, optimal imaging techniques, diagnosis, and applications.
    2021年08月, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 21(1) (1), 168 - 181, 英語, 国内誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 腹部骨盤領域の外傷IVR
    小出 裕, 川崎 竜太, 田口 裕司, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, 2021年08月, 日本医学放射線学会秋季臨床大会抄録集, 57回, S466 - S466, 日本語

  • 抗Ma2抗体陽性の傍腫瘍性辺縁系脳炎の1例
    横尾 紫穂, 宮崎 亜樹, 神田 知紀, 小路田 泰之, 村上 卓道
    (公社)日本医学放射線学会, 2021年08月, 日本医学放射線学会秋季臨床大会抄録集, 57回, S391 - S391, 日本語

  • 耳管軟骨から生じたと考えられる軟骨系腫瘍の1例
    神田 知紀, 神澤 真紀, 宮崎 亜樹, 小路田 泰之, 村上 卓道
    (公社)日本医学放射線学会, 2021年08月, 日本医学放射線学会秋季臨床大会抄録集, 57回, S455 - S455, 日本語

  • 逆チャンス型胸椎骨折による血胸の一例
    松永 直樹, 岡田 卓也, 大野 雄康, 松代 啓吾, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, 2021年08月, 日本医学放射線学会秋季臨床大会抄録集, 57回, S464 - S464, 日本語

  • 慢性血栓塞栓性肺高血圧症患者における、重回帰分析を用いた肺動脈平均圧推定についての検討
    高橋 真依, 松尾 秀俊, 西尾 瑞穂, 松永 卓明, 河野 淳, 谷口 悠, 平田 健一, 村上 卓道
    (公社)日本医学放射線学会, 2021年08月, 日本医学放射線学会秋季臨床大会抄録集, 57回, S400 - S400, 日本語

  • 抗Ma2抗体陽性の傍腫瘍性辺縁系脳炎の1例
    横尾 紫穂, 宮崎 亜樹, 神田 知紀, 小路田 泰之, 村上 卓道
    (公社)日本医学放射線学会, 2021年08月, 日本医学放射線学会秋季臨床大会抄録集, 57回, S391 - S391, 日本語

  • 耳管軟骨から生じたと考えられる軟骨系腫瘍の1例
    神田 知紀, 神澤 真紀, 宮崎 亜樹, 小路田 泰之, 村上 卓道
    (公社)日本医学放射線学会, 2021年08月, 日本医学放射線学会秋季臨床大会抄録集, 57回, S455 - S455, 日本語

  • Masaki Kaibori, Kengo Yoshii, Kosuke Kashiwabara, Takashi Kokudo, Kiyoshi Hasegawa, Namiki Izumi, Takamichi Murakami, Masatoshi Kudo, Shuichiro Shiina, Michiie Sakamoto, Osamu Nakashima, Yutaka Matsuyama, Susumu Eguchi, Tatsuya Yamashita, Tadatoshi Takayama, Norihiro Kokudo, Shoji Kubo
    AIM: We reviewed the data of a nationwide follow-up survey to determine the impact of hepatitis C virus (HCV) infection on the outcomes of hepatectomy for mass-forming (MF) type, and combined mass-forming and periductal infiltrating (MF + PI) type intrahepatic cholangiocarcinoma (ICC). METHODS: In total, 956 patients with ICC who underwent curative hepatic resection were included in this cohort study, and patients were classified according to virus status. Patients were classified according to virus status as follows: HCV-related ICC (n = 138, 14.4%), hepatitis B virus (HBV)-related ICC (n = 43, 4.5%) and non-virus-related ICC (n = 775, 81.1%). To control for variables, we used 1:1 propensity score-matching to compare outcomes after surgery between HCV-related (n = 102) and non-virus-related ICC cases (n = 102). RESULTS: We successfully matched HCV-related and non-virus-related ICC cases with similar liver function and tumor characteristics. Patients with HCV-related ICC had significantly shorter recurrence-free survival (hazard ratio 0.62, 95% confidence interval 0.42-0.92, p = 0.016) and overall survival (hazard ratio: 0.57, 95% confidence interval: 0.37-0.88, p = 0.011) than patients with non-virus-related ICC. Cox proportional hazard analysis showed that HCV-related ICC offered a worse prognosis than non-virus-related ICC. CONCLUSIONS: HCV infection increases the risk of recurrence and worsens overall survival in patients after curative resection for MF and combined MF + PI type ICC.
    Wiley, 2021年08月, Hepatology research : the official journal of the Japan Society of Hepatology, 51(8) (8), 890 - 901, 英語, 国際誌
    研究論文（学術雑誌）

  • Sasaki K, Okada T, Yamaguchi M, Ahmed M, Gentsu T, Ueshima E, Sofue K, Tanimura K, Yamada H, Sugimoto K, Murakami T
    PURPOSE: To evaluate the efficacy of superselective transcatheter arterial embolization (TAE) for intractable postpartum hemorrhage (PPH) due to genital tract trauma (GTT) after vaginal delivery. METHODS: We evaluated 27 patients who underwent TAE for intractable PPH due to GTT after vaginal delivery at our institution between January 2008 and December 2020. Patients were divided into two groups according to TAE procedure; TAE performed as close as possible to the bleeding point, at least more peripherally than the second branch of the anterior division of the internal iliac artery, was defined as superselective TAE (S-TAE). TAE performed from the proximal segment of the internal iliac artery was defined as proximal TAE (P-TAE). Patient characteristics, pre-procedural contrast-enhanced computed tomography (CE-CT), procedure details, technical/clinical success, and complications were evaluated separately for the S-TAE and P-TAE groups. RESULTS: The combined technical/clinical success rate was 92%. No major procedure-related complications were seen (mean follow-up: 6.12 ± 3.93 days). The combined technical/clinical success rate of S-TAE was 100% and of P-TAE was 67% (p = 0.04). S-TAE was performed more frequently in patients with pre-procedural CE-CT (p = 0.01) and use of permanent embolic materials (p = 0.003). CONCLUSION: S-TAE is safe and effective for intractable PPH due to GTT. Pre-procedural CE-CT may be useful for detecting the culprit artery and be helpful in performing S-TAE.
    2021年07月, Emergency radiology[Epub ahead of print], 28(6) (6), 1127 - 1133, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yasuyo Urase, Yoshiko Ueno, Tsutomu Tamada, Keitaro Sofue, Satoru Takahashi, Nobuyuki Hinata, Kenichi Harada, Masato Fujisawa, Takamichi Murakami
    OBJECTIVE: To evaluate the interreader agreement and diagnostic performance of the Prostate Imaging Reporting and Data System (PI-RADS) v. 2.1, in comparison with v. 2. METHODS: Institutional review board approval was obtained for this retrospective study. 77 consecutive patients who underwent a prostate multiparametric magnetic resonance imaging at 3.0 T before radical prostatectomy were included. Four radiologists (two experienced uroradiologists and two inexperienced radiologists) independently scored eight regions [six peripheral zones (PZ) and two transition zones (TZ)] using v. 2.1 and v. 2. Interreader agreement was assessed using κ statistics. To evaluate diagnostic performance for clinically significant prostate cancer (csPC), area under the curve (AUC) was estimated. RESULTS: 228 regions were pathologically diagnosed as positive for csPC. With a cut-off ≥3, the agreement among all readers was better with v. 2.1 than v. 2 in TZ, PZ, or both zones combined (κ-value: TZ, 0.509 vs 0.414; PZ, 0.686 vs 0.568; both zones combined, 0.644 vs 0.531). With a cut-off ≥4, the agreement among all readers was also better with v. 2.1 than v. 2 in the PZ or both zones combined (κ-value: PZ, 0.761 vs 0.701; both zones combined, 0.756 vs 0.709). For all readers, AUC with v. 2.1 was higher than with v. 2 (TZ, 0.826-0.907 vs 0.788-0.856; PZ, 0.857-0.919 vs 0.853-0.902). CONCLUSION: Our study suggests that the PI-RADS v. 2.1 could improve the interreader agreement and might contribute to improved diagnostic performance compared with v. 2. ADVANCES IN KNOWLEDGE: PI-RADS v. 2.1 has a potential to improve interreader variability and diagnostic performance among radiologists with different levels of expertise.
    2021年07月, The British journal of radiology, 95(1131) (1131), 20201434 - 20201434, 英語, 国際誌
    研究論文（学術雑誌）

  • 西尾 瑞穂, 小林 大悟, 松尾 秀俊, 西岡 瑛子, 浦瀬 靖代, 尾上 宏治, 石藏 礼一, 村上 卓道
    This paper reviews the application of deep learning model to the automatic diagnosis of COVID-19 on chest x- ray images. Among various deep learning models proposed for the automatic diagnosis of COVID-19, COVID-NET, CV19- Net, and the authors' model are introduced. The source code is publicly available for these three models, and the datasets of chest x-ray images are also available for two of them. It is expected that these publicly available source codes and datasets of diagnostic models will be useful for the research on diagnostic models of COVID-19 and other diseases. Finally, future work on the author's diagnostic model for COVID-19 is presented.
    医用画像情報学会, 2021年07月, 医用画像情報学会雑誌, 38(2) (2), 53 - 56, 日本語
    [査読有り]

  • Mostafa Hamada, Eisuke Ueshima, Takeaki Ishihara, Yutaka Koide, Takuya Okada, Hiroki Horinouchi, Jun Ishida, Hiroshi Mayahara, Koji Sasaki, Tomoyuki Gentsu, Keitaro Sofue, Masato Yamaguchi, Ryohei Sasaki, Koji Sugimoto, Takamichi Murakami
    Background Technological developments have led to an increased usage of external-body radiotherapy (RT) for the treatment of hepatocellular carcinoma (HCC). Transcatheter arterial chemoembolization (TACE) may be required later in patients treated with RT because of the high recurrence rate and multinodular presentation of HCC. However, despite the risk of liver function impairment, the cumulative liver damage correlated with TACE following a hepatic RT has not been adequately assessed. Purpose To evaluate the feasibility of TACE following RT for HCC. Materials and methods Sixty-seven patients with HCC who underwent TACE after RT were retrospectively evaluated between 2012 and 2018. We assessed increases in Child–Turcotte–Pugh (CTP) by ≥2 points at 1 month, the incidence of major complications, survival duration, and short-term mortality within 6 months after TACE. Furthermore, we evaluated the predictive factors for liver function impairment and short-term mortality. Results Eight patients experienced a CTP increase ≥2 points at 1 month. There were no cases of liver abscesses or bilomas. Nine patients died within 6 months following TACE. The mean liver dose (MLD) was a significant predictor of liver function impairment at 1 month ( p = 0.042). Low liver functional reserve, distant metastasis ( p = 0.037), MLD ( p = 0.046), TACE type ( p = 0.025), and TACE within 3 months following RT ( p = 0.007) were significant predictors of short-term mortality. Conclusions Despite the feasibility of TACE following RT, clinicians should pay attention to impaired pretreatment liver function, following high dose RT, and the short duration between RT and TACE.
    SAGE Publications, 2021年07月, Acta Radiologica Open, 10(7) (7), 205846012110349 - 205846012110349
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Kazuhiro Kitajima, Hidetoshi Matsuo, Atsushi Kono, Kozo Kuribayashi, Takashi Kijima, Masaki Hashimoto, Seiki Hasegawa, Takamichi Murakami, Koichiro Yamakado
    Impact Journals, LLC, 2021年06月, Oncotarget, 12(12) (12), 1187 - 1196
    研究論文（学術雑誌）

  • Masatoshi Kudo, Yusuke Kawamura, Kiyoshi Hasegawa, Ryosuke Tateishi, Kazuya Kariyama, Shuichiro Shiina, Hidenori Toyoda, Yasuharu Imai, Atsushi Hiraoka, Masafumi Ikeda, Namiki Izumi, Michihisa Moriguchi, Sadahisa Ogasawara, Yasunori Minami, Kazuomi Ueshima, Takamichi Murakami, Shiro Miyayama, Osamu Nakashima, Hirohisa Yano, Michiie Sakamoto, Etsuro Hatano, Mitsuo Shimada, Norihiro Kokudo, Satoshi Mochida, Tetsuo Takehara
    The Clinical Practice Manual for Hepatocellular Carcinoma was published based on evidence confirmed by the Evidence-based Clinical Practice Guidelines for Hepatocellular Carcinoma along with consensus opinion among a Japan Society of Hepatology (JSH) expert panel on hepatocellular carcinoma (HCC). Since the JSH Clinical Practice Guidelines are based on original articles with extremely high levels of evidence, expert opinions on HCC management in clinical practice or consensus on newly developed treatments are not included. However, the practice manual incorporates the literature based on clinical data, expert opinion, and real-world clinical practice currently conducted in Japan to facilitate its use by clinicians. Alongside each revision of the JSH Guidelines, we issued an update to the manual, with the first edition of the manual published in 2007, the second edition in 2010, the third edition in 2015, and the fourth edition in 2020, which includes the 2017 edition of the JSH Guideline. This article is an excerpt from the fourth edition of the HCC Clinical Practice Manual focusing on pathology, diagnosis, and treatment of HCC. It is designed as a practical manual different from the latest version of the JSH Clinical Practice Guidelines. This practice manual was written by an expert panel from the JSH, with emphasis on the consensus statements and recommendations for the management of HCC proposed by the JSH expert panel. In this article, we included newly developed clinical practices that are relatively common among Japanese experts in this field, although all of their statements are not associated with a high level of evidence, but these practices are likely to be incorporated into guidelines in the future. To write this article, coauthors from different institutions drafted the content and then critically reviewed each other's work. The revised content was then critically reviewed by the Board of Directors and the Planning and Public Relations Committee of JSH before publication to confirm the consensus statements and recommendations. The consensus statements and recommendations presented in this report represent measures actually being conducted at the highest-level HCC treatment centers in Japan. We hope this article provides insight into the actual situation of HCC practice in Japan, thereby affecting the global practice pattern in the management of HCC.
    S. Karger AG, 2021年06月, Liver cancer, 10(3) (3), 181 - 223, 英語, 国際誌
    研究論文（学術雑誌）

  • 工藤 正俊, 泉 並木, 久保 正二, 國土 典宏, 坂元 亨宇, 椎名 秀一朗, 高山 忠利, 建石 良介, 中島 収, 村上 卓道, 松山 裕, 高橋 新, 宮田 裕章, 田村 利恵, 上妻 智子, 日本肝癌研究会追跡調査委員会
    第22回全国原発性肝癌追跡調査においては,2012年1月1日から2013年12月31日までの2年間の21,155例の新規症例と43,041例の追跡症例が538施設から集計された.基礎統計は,第22回新規登録症例を対象として死因,既往歴,臨床診断,画像診断,治療法別の各因子,病理診断,再発,剖検についてまとめた.第21回調査と比較し,肝細胞癌における臨床診断時の高齢化,女性の増加,非B非C肝癌の増加,腫瘍径の縮小の傾向が,治療においては切除の割合の増加,局所療法におけるラジオ波焼灼療法の増加が認められた.2002年から2013年まで新規登録症例の中で最終予後が生存または死亡となった症例(追跡不能症例を除く)について肝細胞癌,肝内胆管癌,混合型肝癌の治療法別,背景因子別生存中央値・累積生存率を算出した.肝細胞癌については腫瘍個数,腫瘍径,肝障害度,Child-Pugh分類を組み合わせることにより背景因子を揃えて,治療法別(肝切除,局所療法,肝動脈塞栓療法(TACE)),肝動注化学療法・全身薬物療法(分子標的治療)の累積生存率を算出し,また,1978年から2013年までの新規登録症例を5期に分け,累積生存率を算出した.新規登録症例数は経時的に増加し,肝細胞癌,肝内胆管癌,混合型肝癌ともに予後の改善が著しいことが明らかとなった.本追跡調査が原発性肝癌の研究および診療の進歩に役立つことを期待する.(著者抄録)
    (一社)日本肝臓学会, 2021年05月, 肝臓, 62(5) (5), 251 - 299, 日本語

  • 工藤正俊, 泉 並木, 久保正二, 國土典宏, 坂元亨宇, 椎名秀一朗, 高山忠利, 建石良介, 中島 収, 村上卓道, 松山 裕, 高橋 新, 宮田裕章, 田村利恵, 上妻智子, 日本肝癌研究会追跡調査委員会
    (一社)日本肝臓学会, 2021年05月, 肝臓, 62(5) (5), 251 - 299, 日本語

  • Kawaguchi Y, Hasegawa K, Hagiwara Y, Bellis M.D, Famularo S, Panettieri E, Matsuyama Y, Tateishi R, Ichikawa T, Kokudo T, Izumi N, Kubo S, Sakamoto M, Shiina S, Takayama T, Nakashima O, Murakami T, Vauthey J.N, Giuliante F, Carlis L.D, Romano F, Ruzzenente A, Guglielmi A, Kudo M, Kokudo N
    INTRODUCTION: Most studies predicting survival after resection, transarterial chemoembolization (TACE), and ablation analyzed diameter and number of hepatocellular carcinomas (HCCs) as dichotomous variables, resulting in an underestimation of risk variation. We aimed to develop and validate a new prognostic model for patients with HCC using largest diameter and number of HCCs as continuous variables. METHODS: The prognostic model was developed using data from patients undergoing resection, TACE, and ablation in 645 Japanese institutions. The model results were shown after balanced using the inverse probability of treatment-weighted analysis and were externally validated in an international multi-institution cohort. RESULTS: Of 77,268 patients, 43,904 patients, including 15,313 (34.9%) undergoing liver resection, 13,375 (30.5%) undergoing TACE, and 15,216 (34.7%) undergoing ablation, met the inclusion criteria. Our model (http://www.u-tokyo-hbp-transplant-surgery.jp/about/calculation.html) showed that the 5-year overall survival (OS) in patients with HCC undergoing these procedures decreased with progressive incremental increases in diameter and number of HCCs. For patients undergoing resection, the inverse probability of treatment-weighted-adjusted 5-year OS probabilities were 10%-20% higher compared with patients undergoing TACE for 1-6 HCC lesions <10 cm and were also 10%-20% higher compared with patients undergoing ablation when the HCC diameter was 2-3 cm. For patients undergoing resection and TACE, the model performed well in the external cohort. DISCUSSION: Our novel prognostic model performed well in predicting OS after resection and TACE for HCC and demonstrated that resection may have a survival benefit over TACE and ablation based on the diameter and number of HCCs.
    2021年04月, The American journal of gastroenterology[Epub ahead of print], 116(8) (8), 1698 - 1708, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Kojita Y, Matsuo H, Kanda T, Nishio M, Sofue K, Nogami M, Kono AK, Hori M, Murakami T
    OBJECTIVES: To evaluate a deep learning model for predicting gestational age from fetal brain MRI acquired after the first trimester in comparison to biparietal diameter (BPD). MATERIALS AND METHODS: Our Institutional Review Board approved this retrospective study, and a total of 184 T2-weighted MRI acquisitions from 184 fetuses (mean gestational age: 29.4 weeks) who underwent MRI between January 2014 and June 2019 were included. The reference standard gestational age was based on the last menstruation and ultrasonography measurements in the first trimester. The deep learning model was trained with T2-weighted images from 126 training cases and 29 validation cases. The remaining 29 cases were used as test data, with fetal age estimated by both the model and BPD measurement. The relationship between the estimated gestational age and the reference standard was evaluated with Lin's concordance correlation coefficient (ρc) and a Bland-Altman plot. The ρc was assessed with McBride's definition. RESULTS: The ρc of the model prediction was substantial (ρc = 0.964), but the ρc of the BPD prediction was moderate (ρc = 0.920). Both the model and BPD predictions had greater differences from the reference standard at increasing gestational age. However, the upper limit of the model's prediction (2.45 weeks) was significantly shorter than that of BPD (5.62 weeks). CONCLUSIONS: Deep learning can accurately predict gestational age from fetal brain MR acquired after the first trimester. KEY POINTS: • The prediction of gestational age using ultrasound is accurate in the first trimester but becomes inaccurate as gestational age increases. • Deep learning can accurately predict gestational age from fetal brain MRI acquired in the second and third trimester. • Prediction of gestational age by deep learning may have benefits for prenatal care in pregnancies that are underserved during the first trimester.
    2021年04月, European radiology[Epub ahead of print], 31(6) (6), 3775 - 3782, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 当院における大動脈解離に伴う腎動脈狭窄に対するステント留置術の中期成績
    小出 裕, 川崎 竜太, 松代 啓吾, 丸山 晃司, 岡田 卓也, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2021年04月, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 162 - 162, 日本語

  • 大動脈腸骨動脈閉塞性病変に対するViabahn VBXの初期使用経験
    上月 瞭平, 宮本 直和, 津田 成康, 田頭 達, 山田 愼一郎, 難波 富美子, 大森 美佳, 足立 秀治, 粟野 孝次郎, 冨田 優, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2021年04月, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 163 - 163, 日本語

  • 腎動脈下部大動脈腸骨動脈閉塞に対する血管内治療の初期経験
    谷 龍一郎, 宮本 直和, 津田 成康, 田頭 達, 山田 愼一郎, 上月 瞭平, 難波 富美子, 大森 美佳, 足立 秀治, 粟野 孝次郎, 冨田 優, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2021年04月, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 235 - 235, 日本語

  • Prognostic grade for resecting hepatocellular carcinoma: multicentre retrospective study.
    Takayama T, Yamazaki S, Matsuyama Y, Midorikawa Y, Shiina S, Izumi N, Hasegawa K, Kokudo N, Sakamoto M, Kubo S, Kudo M, Murakami T, Nakashima O
    2021年04月, Liver Cancer Study Group of Japan. Br J Surg., 108(4) (4), 412 - 418, 英語
    [査読有り]

  • 山本 雄也, 上野 嘉子, 松田 耕平, 野上 宗伸, 出口 雅士, 上原 慶一郎, 三木 智子, 村上 卓道
    症例は70歳代女性で、帯下、不正性器出血を主訴に受診し、子宮に腫瘤性病変を指摘された。MRIでは子宮体部に91×73×78mm大の腫瘤を認めた。画像所見からは子宮肉腫が疑われたが、由来部位が同定困難であり、非類内膜腺癌なども鑑別に挙げられた。腫瘤は複数の成分からなっており、T2強調像では腹側部は低信号、背頭部は比較的高信号、背尾側部は中程度の高信号を呈していた。18F-FDG PETでは腹側部はFDG集積が弱く、背頭部には軽度の集積、背尾部に強い集積を認めた。肉眼所見では子宮内腔に腫瘤が充満していた。画像所見にみられた腫瘍の各成分についての病理学的な特徴は以下のとおりであった。腫瘤腹側部には、異型の乏しい腺管構造が散見され、大小不同の核を呈する紡錘形細胞が認められた。腫瘤背頭部には、典型性の強い紡錘形細胞が多数認められ、正常な腺構造は認められなかった。腫瘤背頭部では、異型性の強い紡錘形細胞や壊死組織、炎症細胞が多数認められた。細胞密度は高く、正常な腺構造は認められなかった。根治的手術(子宮全摘術および両側付属器切除)が実施され、病理学的に腺肉腫の診断がなされた。子宮筋層の深部浸潤があり、pT1c FIGO IC期相当と判断された。術後特に問題なく退院となったが、術後2年3ヵ月で多発肺転移が生じた。全身状態良好であり、転移病変の増大が遅い点から経過観察の方針となり、術後3年9ヵ月時点では無症状で生存している。
    金原出版(株), 2021年04月, 臨床放射線, 66(4) (4), 381 - 385, 日本語

  • 大動脈疾患に対するIVR治療の現況と課題 EVARの遠隔期成績向上への取り組み
    元津 倫幸, 山口 雅人, 佐々木 康二, Hamada Mostafa, 上嶋 英介, 岡田 卓也, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2021年04月, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 125 - 125, 日本語

  • Shaggy aorta症例における上腸間膜動脈バルーンプロテクション併用下TEVARの有用性の検討
    佐々木 康二, 岡田 卓也, 山口 雅人, 田尻 昌士, Hamada Mostafa, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2021年04月, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 160 - 160, 日本語

  • ウサギVX2腫瘍モデルを用いた過酸化チタンナノ粒子動注の基礎的研究
    岡田 卓也, 元津 倫幸, 西村 勇哉, 森田 健太, 上嶋 英介, 山口 雅人, 杉本 幸司, 佐々木 良平, 荻野 千秋, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2021年04月, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 191 - 191, 日本語

  • 上顎癌動注化学療法における腫瘍進展方向と栄養血管に関する検討(Tumor extension and feeding arteries in intraarterial chemotherapy for maxillary cancer)
    Hamada Mostafa, 岡田 卓也, 山口 雅人, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2021年04月, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 201 - 201, 英語

  • 陰部腟静脈瘤に対し血管内治療を行った1例
    田尻 昌士, 岡田 卓也, Ahmed Mostafa, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2021年04月, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 251 - 251, 日本語

  • 【肝内胆管癌の診断と治療】肝内胆管癌のスクリーニングと診断指針
    杉本勝俊, 糸井隆夫, 南 康範, 工藤正俊, 藤永康成, 角谷眞澄, 村上卓道
    (有)科学評論社, 2021年04月, 消化器・肝臓内科, 9(4) (4), 417 - 421, 日本語

  • 【肝内胆管癌の診断と治療】肝内胆管癌の画像診断
    藤永康成, 南 康範, 杉本勝俊, 糸井隆夫, 工藤正俊, 村上卓道, 角谷眞澄
    (有)科学評論社, 2021年04月, 消化器・肝臓内科, 9(4) (4), 422 - 428, 日本語

  • 祖父江慶太郎, 上嶋英介, 村上卓道, 矢部慎二, 辻田有志, 山口 尊, 上野嘉子, 堀 雅敏
    ＜文献概要＞本特別企画に選出いただいたテーマは,第56回日本医学放射線学会秋季臨床大会で講演した内容である。肝細胞癌診断における造影CTの位置付けとその画像所見の成り立ち,診断能向上における最近の研究についてまとめたものであり,主に放射線科診断専門医資格取得前後の若い先生方を対象とした内容となっている。
    (株)メジカルビュー社, 2021年04月, 臨床画像, 37(4) (4), 490 - 497, 日本語

  • Masakatsu Tsurusaki, Keitaro Sofue, Hiromitsu Onishi, Satoshi Goshima, Atsushi Higaki, Hiroyoshi Isoda, Hiroki Haradome, Kazunari Ishii, Takamichi Murakami
    2021年04月, Japanese journal of radiology, 39(4) (4), 405 - 405, 英語, 国内誌

  • Kudo M, Izumi N, Kokudo N, Sakamoto M, Shiina S, Takayama T, Tateishi R, Nakashima O, Murakami T, Matsuyama Y, Takahashi A, Miyata H, Kudo S
    In the 21st Nationwide Follow-up Survey of Primary Liver Cancer in Japan, data from 22,134 new patients and 41,956 previously followed patients were compiled from 546 institutions over a 2-year period from 1 January 2010 to 31 December 2011. Basic statistics compiled for patients newly registered in the 21st survey were cause of death, medical history, clinical diagnosis, imaging diagnosis, treatment-related factors, pathological diagnosis, recurrence status, and autopsy findings. Compared with the previous 20th survey, the population of patients with hepatocellular carcinoma (HCC) was older at the time of clinical diagnosis, had more female patients, had more patients with non-B non-C HCC, had smaller tumor diameter, and was more frequently treated with hepatectomy and with radiofrequency ablation. Cumulative survival rates were calculated for HCC, intrahepatic cholangiocarcinoma, and combined hepatocellular cholangiocarcinoma (combined HCC and intrahepatic cholangiocarcinoma) by treatment type and background characteristics for patients newly registered between 1998 and 2011 whose final outcome was survival or death (excluding unknown). Cumulative survival rates for HCC were calculated by dividing patients by combinations of background factors (number of tumors, tumor diameter, and Child-Pugh grade) and by treatment type (hepatectomy, local ablation therapy, transcatheter arterial chemoembolization, and hepatic arterial infusion chemotherapy). The same values were also calculated according to registration date by dividing patients newly registered between 1978 and 2011 into four time-period groups. The data obtained from this nationwide follow-up survey are expected to contribute to advancing clinical research and treatment of primary liver cancer.
    Wiley, 2021年04月, Hepatology Research, 51(4) (4), 355 - 405, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Nogami M, Zeng F, Inukai J, Watanabe Y, Nishio M, Kanda T, Ueno Y R, Sofue K, Kono A K, Hori M, Ohnishi A, Kubo K, Kurimoto T, Murakami T
    Purpose To retrospectively assess the repeatability of physiological F-18 labeled fluorodeoxyglucose (FDG) uptake in the skin on positron emission tomography/magnetic resonance imaging (PET/MRI) and explore its regional distribution and relationship with sex and age. Methods Out of 562 examinations with normal FDG distribution on whole-body PET/MRI, 74 repeated examinations were evaluated to assess the repeatability and regional distribution of physiological skin uptake. Furthermore, 224 examinations were evaluated to compare differences in the uptake due to sex and age. Skin segmentation on PET was performed as body-surface contouring on an MR-based attenuation correction map using an off-line reconstruction software. Bland–Altman plots were created for the repeatability assessment. Kruskal–Wallis test was performed to compare the maximum standardized uptake value (SUVmax) with regional distribution, age, and sex. Results The limits of agreement for the difference in SUVmean and SUVmax of the skin were less than 30%. The highest SUVmax was observed in the face (3.09±1.04), followed by the scalp (2.07±0.53). The SUVmax in the face of boys aged 0–9 years and 10–20 years (1.33±0.64 and 2.05±1.00, respectively) and girls aged 0–9 years (0.98±0.38) was significantly lower than that of men aged ≥20 years and girls aged ≥10 years (p<0.001). In women, the SUVmax of the face (2.31±0.71) of ≥70-year-olds was significantly lower than that of 30–39-year-olds (3.83±0.82) (p<0.05). Conclusion PET/MRI enabled the quantitative analysis of skin FDG uptake with repeatability. The degree of physiological FDG uptake in the skin was the highest in the face and varied between sexes. Although attention to differences in body habitus between age groups is needed, skin FDG uptake also depended on age.
    Public Library of Science (PLoS), 2021年03月, PLOS ONE, 16(3) (3), e0249304 - e0249304
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yasunori Minami, Tomohiro Minami, Kazuomi Ueshima, Yukinobu Yagyu, Masakatsu Tsurusaki, Takuya Okada, Masatoshi Hori, Masatoshi Kudo, Takamichi Murakami
    Background: We investigate the feasibility of image fusion application for ablative margin assessment in radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) and possible causes for a wrong initial evaluation of technical success through a side-by-side comparison. Methods: A total of 467 patients with 1100 HCCs who underwent RFA were reviewed retrospectively. Seventeen patients developed local tumor progressions (LTPs) (median size, 1.0 cm) despite initial judgments of successful ablation referring to contrast-enhanced images obtained in the 24 h after ablation. The ablative margins were reevaluated radiologically by overlaying fused images pre- and post-ablation. Results: The initial categorizations of the 17 LTPs had been grade A (absolutely curative) (n = 5) and grade B (relatively curative) (n = 12); however, the reevaluation altered the response categories to eight grade C (margin-zero ablation) and nine grade D (existence of residual HCC). LTP occurred in eight patients re-graded as C within 4 to 30.3 months (median, 14.3) and in nine patients re-graded as D within 2.4 to 6.7 months (median, 4.2) (p = 0.006). Periablational hyperemia enhancements concealed all nine HCCs reevaluated as grade D. Conclusion: Side-by-side comparisons carry a risk of misleading diagnoses for LTP of HCC. Overlay fused imaging technology can be used to evaluate HCC ablative margin with high accuracy.
    MDPI AG, 2021年03月, Cancers, 13(6) (6), 1460 - 1460, 英語
    研究論文（学術雑誌）

  • Isao Numoto, Masakatsu Tsurusaki, Teruyoshi Oda, Yukinobu Yagyu, Kazunari Ishii, Takamichi Murakami
    The authors are sorry to report that the overall survival reported in their recently published paper was incorrect [...].
    2021年03月, Cancers, 13(6) (6), 英語, 国際誌

  • 超高精細CTのための深層学習に基づくイメージ超解像処理(Deep-learning-based Image Super Resolution for Super High-resolution Computed Tomography)
    Nishio Mizuho, Yamagishi Yosuke, Matsuo Hidetoshi, Kagawa Kiyosumi, Negi Noriyuki, Kono Atsushi, Murakami Takamichi
    (公社)日本医学放射線学会, 2021年03月, 日本医学放射線学会学術集会抄録集, 80回, S203 - S203, 英語

  • 西岡 瑛子, 上野 嘉子, 村上 卓道
    ＜Point!＞・転移性卵巣腫瘍と原発性卵巣腫瘍はそれぞれ患者の予後や治療方針が異なるため、これらの鑑別は臨床的意義が高く、画像検査は非侵襲的診断法として重要な役割を果たす。しかし転移性卵巣腫瘍はその原発巣によって病理学的特徴が異なり、様々な形態を呈しうる。・原発巣により一定の傾向はあるものの、転移性卵巣腫瘍の画像所見は原発性卵巣腫瘍とオーバーラップする点が多い。術前診断は困難な場合も多く、画像所見や臨床所見などを総合的に考える必要がある。・本稿では一般的な転移性卵巣腫瘍の画像的特徴とともに、原発巣ごとのポイントや鑑別を要する原発性卵巣腫瘍についてまとめた。(著者抄録)
    (株)診断と治療社, 2021年03月, 産科と婦人科, 88(Suppl.) (Suppl.), 384 - 392, 日本語

  • Maruyama K, Okada T, Ueha T, Isohashi K, Ikeda H, Kanai Y, Sasaki K, Gentsu T, Ueshima E, Sofue K, Nogami M, Yamaguchi M, Sugimoto K, Sakai Y, Hatazawa J, Murakami T
    Carbon dioxide (CO2) treatment is reported to have an antitumor effect owing to the improvement in intratumoral hypoxia. Previous studies were based on histological analysis alone. In the present study, the improvement in intratumoral hypoxia by percutaneous CO2 treatment in vivo was determined using 18F-fluoromisonidazole positron emission tomography-computed tomography (18F-FMISO PET-CT) images. Twelve Japanese nude mice underwent implantation of LM8 tumor cells in the dorsal subcutaneous area 2 weeks before percutaneous CO2 treatment and 18F-FMISO PET-CT scans. Immediately after intravenous injection of 18F-FMISO, CO2 and room air were administered transcutaneously in the CO2-treated group (n=6) and a control group (n=6), respectively; each treatment was performed for 10 minutes. PET-CT was performed 2 h after administration of 18F-FMISO. 18F-FMISO tumor uptake was quantitatively evaluated using the maximum standardized uptake value (SUVmax), tumor-to-liver ratio (TLR), tumor-to-muscle ratio (TMR), metabolic tumor volume (MTV) and total lesion glycolysis (TLG). Mean ± standard error of the mean (SEM) of the tumor volume was not significantly different between the two groups (CO2-treated group, 1.178±0.450 cm3; control group, 1.368±0.295 cm3; P=0.485). Mean ± SEM of SUVmax, TLR, MTV (cm3) and TLG were significantly lower in the CO2-treated group compared with the control group (0.880±0.095 vs. 1.253±0.071, P=0.015; 1.063±0.147361 vs. 1.455±0.078, P=0.041; 0.353±0.139 vs. 1.569±0.438, P=0.015; 0.182±0.070 vs. 1.028±0.338, P=0.015), respectively. TMR was not significantly different between the two groups (4.520±0.503 vs. 5.504±0.310; P=0.240). In conclusion, 18F-FMISO PET revealed that percutaneous CO2 treatment improved intratumoral hypoxia in vivo. This technique enables assessment of the therapeutic effect in CO2 treatment by imaging, and may contribute to its clinical application.
    2021年03月, Oncology letters, 21(3) (3), 207 - 207, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Ito J, Nogami M, Morita Y, Sakaguchi K, Komada H, Hirota Y, Sugawara K, Tomori Y, Zeng F, Murakami T, Ogawa W
    AIM: To investigate the relationships between various clinical variables and the metformin-induced accumulation of fluorodeoxyglucose (FDG) in the intestine, with distinction between the intestinal wall and lumen, in individuals with type 2 diabetes who were receiving metformin treatment and underwent 18 F-labelled FDG ([18 F]FDG) positron emission tomography (PET)-MRI. MATERIALS AND METHODS: We evaluated intestinal accumulation of [18 F]FDG with both subjective (a five-point visual scale determined by two experienced radiologists) and objective analyses (measurement of the maximum standardized uptake value [SUVmax ]) in 26 individuals with type 2 diabetes who were receiving metformin and underwent [18 F]FDG PET-MRI. [18 F]FDG accumulation within the intestinal wall was discriminated from that in the lumen on the basis of SUVmax . RESULTS: SUVmax for the large intestine was correlated with blood glucose level (BG) and metformin dose, but not with age, body mass index, HbA1c level or estimated glomerular filtration rate (eGFR). SUVmax for the small intestine was not correlated with any of these variables. Visual scale analysis yielded essentially similar results. Metformin dose and eGFR were correlated with SUVmax for the wall and lumen of the large intestine, whereas BG was correlated with that for the wall. Multivariable analysis identified metformin dose as an explanatory factor for SUVmax in the wall and lumen of the large intestine after adjustment for potential confounders including BG and eGFR. CONCLUSIONS: Metformin dose is an independent determinant of [18 F]FDG accumulation in the wall and lumen of the large intestine in individuals treated with this drug.
    Wiley, 2021年03月, Diabetes Obesity and Metabolism, 23(3) (3), 692 - 699, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Oe K, Zeng F, Fukui T, Nogami M, Murakami T, Matsumoto T, Kuroda R, Niikura T
    BACKGROUND: Recently, a standardized uptake value (SUV) has been used to evaluate bone single-photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected nonunion to compare hypertrophic nonunion and non-hypertrophic nonunion using volume-based parameters. METHODS: We evaluated 23 patients with uninfected nonunion who underwent SPECT acquisition 3 h after an injection of 99mTc-hydroxymethylene diphosphonate or 99mTc-methylene diphosphonate from April 2014 to November 2019. We reconstructed the acquired data and performed voxel-based quantitative analysis using the GI-BONE software. Quantitative parameters, maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean) in the high and low uptake areas of nonunion were compared between hypertrophic nonunion and non-hypertrophic nonunion. The contralateral limb was used as a control, and the ratios of the quantitative parameters were calculated. RESULTS: The values for the quantitative parameters (high uptake area/low uptake area, respectively), SUVmax control ratio (12.13 ± 4.95/6.44 ± 4.71), SUVpeak control ratio (11.65 ± 4.58/6.45 ± 4.64), and SUVmean control ratio (11.94 ± 5.03/6.28 ± 4.95) for hypertrophic nonunion were higher than those for non-hypertrophic nonunion (7.82 ± 4.76/3.41 ± 2.09 (p = 0.065/0.12), 7.56 ± 4.51/3.61 ± 2.23 (p = 0.065/0.22), and 7.59 ± 5.18/3.05 ± 1.91 (p = 0.076/0.23)). CONCLUSIONS: SUVmax, SUVpeak, and SUVmean control ratios obtained from bone SPECT images can quantitatively evaluate the biological activity of nonunions and may be an effective evaluation method for treatment decisions, especially the necessity of autologous bone grafting.
    2021年02月, Journal of orthopaedic surgery and research, 16(1) (1), 125 - 125, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Aoki T, Kubota K, Kubo S, Eguchi S, Izumi N, Kokudo N, Sakamoto M, Shiina S, Takayama T, Nakashima O, Matsuyama Y, Murakami T, Kudo M
    BACKGROUND: Non-curative (debulking) hepatic resection for hepatocellular carcinoma (HCC) is occasionally applied for selected cases with bulky tumors or for oncologic emergency cases; however, the clinical usefulness of this procedure has not yet been fully evaluated. The aim of the present study was to evaluate the patient outcomes of non-curative hepatic resections for HCC using data from bi-annual nationwide surveys conducted in Japan. METHOD: Data of 1084 non-curative hepatic resections for HCC were collected. The patient outcomes were compared with those of curative resections, transcatheter arterial chemoembolization (TACE), and hepatic arterial infusion chemotherapy (HAIC). RESULTS: Patient survival after the non-curative resection was poorer than that after curative resection (P < 0.001) and was especially dismal in cases with extrahepatic tumor spread (lymph node metastasis, peritoneal seeding, or distant metastasis). As compared to cases receiving TACE without surgery, non-curative resections for multiple intrahepatic tumors were applied to cases with advanced tumors with good liver functional reserve. The survival outcomes were significantly more favorable in the TACE group, but the results became similar after propensity score matching of the patients. The survival outcome of patients receiving non-curative resections was better than that of cases treated by HAIC, with median survival times of 26.0 months and 10.0 months, respectively. CONCLUSION: The indications for non-curative hepatic resection in patients with HCC should be judged cautiously, especially in patients with extrahepatic tumor spread. This treatment approach may be beneficial for selected patients with intermediate- or advanced-stage HCC limited in liver and with good liver functional reserve.
    2021年02月, World journal of surgery, 45(2) (2), 607 - 614, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Koh DM, Ba-Ssalamah A, Brancatelli G, Fananapazir G, Fiel MI, Goshima S, Ju SH, Kartalis N, Kudo M, Lee JM, Murakami T, Seidensticker M, Sirlin CB, Tan CH, Wang J, Yoon JH, Zeng M, Zhou J, Taouli B
    OBJECTIVES: The 9th International Forum for Liver Magnetic Resonance Imaging (MRI) was held in Singapore in September 2019, bringing together radiologists and allied specialists to discuss the latest developments in and formulate consensus statements for liver MRI, including the applications of gadoxetic acid-enhanced imaging. METHODS: As at previous Liver Forums, the meeting was held over 2 days. Presentations by the faculty on days 1 and 2 and breakout group discussions on day 1 were followed by delegate voting on consensus statements presented on day 2. Presentations and discussions centered on two main meeting themes relating to the use of gadoxetic acid-enhanced MRI in primary liver cancer and metastatic liver disease. RESULTS AND CONCLUSIONS: Gadoxetic acid-enhanced MRI offers the ability to monitor response to systemic therapy and to assist in pre-surgical/pre-interventional planning in liver metastases. In hepatocellular carcinoma, gadoxetic acid-enhanced MRI provides precise staging information for accurate treatment decision-making and follow-up post therapy. Gadoxetic acid-enhanced MRI also has potential, currently investigational, indications for the functional assessment of the liver and the biliary system. Additional voting sessions at the Liver Forum debated the role of multidisciplinary care in the management of patients with liver disease, evidence to support the use of abbreviated imaging protocols, and the importance of standardizing nomenclature in international guidelines in order to increase the sharing of scientific data and improve the communication between centers. KEY POINTS: • Gadoxetic acid-enhanced MRI is the preferred imaging method for pre-surgical or pre-interventional planning for liver metastases after systemic therapy. • Gadoxetic acid-enhanced MRI provides accurate staging of HCC before and after treatment with locoregional/biologic therapies. • Abbreviated protocols for gadoxetic acid-enhanced MRI offer potential time and cost savings, but more evidence is necessary. The use of gadoxetic acid-enhanced MRI for the assessment of liver and biliary function is under active investigation.
    2021年02月, European radiology[Epub ahead of print], 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Tsurusaki M, Sofue K, Onishi H, Goshima S, Higaki A, Isoda H, Haradome H, Ishii K, Murakami T
    PURPOSE: To identify predictive factors for truncation artifacts (TAs) in the arterial phase of Gd-EOB-DTPA-enhanced MRI in a multicenter study in Japan. MATERIALS AND METHODS: Data on patient factors (age, sex, weight, presence of viral hepatitis, and other conditions) and imaging parameters (e.g., triggering, voxel size, matrix, k-space ordering, acquisition time, reduction factor, flip angle, fat suppression, field strength, injection rate, and saline volume) were obtained. Univariate and multivariate analyses were performed to investigate the correlation of these parameters. RESULTS: We evaluated 1444 patients from 43 institutions who were scanned using GE, Siemens, Philips, or Toshiba MRI equipment (501, 354, 349, and 240 patients, respectively). The total incidence of TAs was 12.5% (17.2, 3.6, 15.7, and 12.1%, respectively). The matrix [odds ratio (OR) 0.13], flip angle (OR 5.77), use of fat suppression (OR 0.106), and field strength (OR 0.092) used in the Philips equipment significantly increased the incidence of TAs in MRI examination. CONCLUSIONS: The incidence of TAs in the arterial phase is influenced by several patient factors and imaging parameters. Especially, Siemens and Toshiba equipment had a significantly lower frequency of TAs. This indicates that such vendor-specific technology used in the dynamic sequence may have a TA-resistant effect.
    Springer Science and Business Media LLC, 2021年02月, Japanese journal of radiology, 39(2) (2), 165 - 177, 英語, 国内誌
    研究論文（学術雑誌）

  • Tsurusaki M, Sofue K, Hori M, Sasaki K, Ishii K, Murakami T, Kudo M
    Dual-energy computed tomography (DECT) is an imaging technique based on data acquisition at two different energy settings. Recent advances in CT have allowed data acquisitions and simultaneous analyses of X-rays at two energy levels, and have resulted in novel developments in the field of abdominal imaging. The use of low and high X-ray tube voltages in DECT provide fused images that improve the detection of liver tumors owing to the higher contrast-to-noise ratio (CNR) of the tumor compared with the liver. The use of contrast agents in CT scanning improves image quality by enhancing the CNR and signal-to-noise ratio while reducing beam-hardening artifacts. DECT can improve detection and characterization of hepatic abnormalities, including mass lesions. The technique can also be used for the diagnosis of steatosis and iron overload. This article reviews and illustrates the different applications of DECT in liver imaging.
    MDPI AG, 2021年01月, Diagnostics (Basel, Switzerland), 11(2) (2), 161 - 161, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • 肺転移の診断能と融合画像精度におけるZTE併用FDG PET/MRIとPET/CTとの比較
    犬養 純子, 野上 宗伸, 曽 菲比, 立花 美保, 久保 和広, 栗本 貴子, 村上 卓道
    (一社)日本核医学会, 2021年, 核医学, 58(Suppl.) (Suppl.), S196 - S196, 日本語

  • 深層学習を用いたZTE MRIによる胸部PET/MRIの吸収補正に関する定量的検証
    野上 宗伸, 松尾 秀俊, 西尾 瑞穂, 曽 菲比, 犬養 純子, 立花 美保, 栗本 貴子, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2021年, 核医学, 58(Suppl.) (Suppl.), S196 - S196, 英語

  • 非感染性偽関節に対する骨SPECTの定量評価(Quantitative evaluation of bone SPECT for uninfected nonunion)
    曽 菲比, 大江 啓介, 野上 宗伸, 犬養 純子, 立花 美保, 久保 和広, 福井 友章, 新倉 隆宏, 黒田 良祐, 村上 卓道
    (一社)日本核医学会, 2021年, 核医学, 58(Suppl.) (Suppl.), S198 - S198, 英語

  • 犬養 純子, 野上 宗伸, 曽 菲比, 立花 美保, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2021年, 核医学, 58(1) (1), 79 - 79, 日本語

  • 立花 美保, 野上 宗伸, 犬養 純子, 曽 菲比, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2021年, 核医学, 58(1) (1), 79 - 80, 日本語

  • 野上 宗伸, 立花 美保, 犬養 純子, 曽 菲比, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2021年, 核医学, 58(1) (1), 80 - 80, 日本語

  • 肺転移の診断能と融合画像精度におけるZTE併用FDG PET/MRIとPET/CTとの比較
    犬養 純子, 野上 宗伸, 曽 菲比, 立花 美保, 久保 和広, 栗本 貴子, 村上 卓道
    (一社)日本核医学会, 2021年, 核医学, 58(Suppl.) (Suppl.), S196 - S196, 日本語

  • 非感染性偽関節に対する骨SPECTの定量評価(Quantitative evaluation of bone SPECT for uninfected nonunion)
    曽 菲比, 大江 啓介, 野上 宗伸, 犬養 純子, 立花 美保, 久保 和広, 福井 友章, 新倉 隆宏, 黒田 良祐, 村上 卓道
    (一社)日本核医学会, 2021年, 核医学, 58(Suppl.) (Suppl.), S198 - S198, 英語

  • 【血管内治療における抗血栓療法】外傷性・医原性血管損傷に対するバイアバーン留置後の抗血栓療法
    岡田 卓也, 松代 啓吾, Hamada Mostafa, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    外傷性・医原性血管損傷に対するバイアバーンステントグラフト留置後の抗血栓療法には定まった見解はなく、治療担当医の判断に委ねられている。浅大腿動脈の閉塞性疾患に対するバイアバーン留置後の抗血栓療法に準じた治療が行われることが多いが、治療血管の部位や再出血のリスクなどを鑑みて調整する必要がある。腹部分枝では、血管の蛇行や血管周囲の炎症や感染など、グラフト閉塞の原因となり得る因子がある一方で、必ずしも長期開存が求められない場合もある。腸骨動脈では、グラフト閉塞の可能性は基本的に低いと思われるため、場合によっては抗血栓療法を行わないのも一つの選択肢である。反対に、鎖骨下動脈では確実な開存性を担保したい場合が多く、抗血栓療法は必須と考える。外傷性・医原性出血に対するバイアバーンステントグラフトの長期成績はいまだ不明であり、さらなるエビデンスの構築が望まれる。(著者抄録)
    (一社)日本血管内治療学会, 2021年, 日本血管内治療学会誌, 22(1) (1), 50 - 53, 日本語

  • 深層学習を用いたZTE MRIによる胸部PET/MRIの吸収補正に関する定量的検証
    野上 宗伸, 松尾 秀俊, 西尾 瑞穂, 曽 菲比, 犬養 純子, 立花 美保, 栗本 貴子, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2021年, 核医学, 58(Suppl.) (Suppl.), S196 - S196, 英語

  • CT or MRI CT、MRIどっちを依頼?(No.10) 肝 超音波検査で肝に腫瘤が疑われた
    祖父江 慶太郎, 村上 卓道
    (公社)日本医師会, 2021年01月, 日本医師会雑誌, 149(10) (10), 1808 - 1809, 日本語

  • 工藤 正俊, 泉 並木, 久保 正二, 國土 典宏, 坂元 亨宇, 椎名 秀一朗, 高山 忠利, 建石 良介, 中島 収, 村上 卓道, 松山 裕, 高橋 新, 宮田 裕章, 田村 利恵, 上妻 智子, 日本肝癌研究会追跡調査委員会
    第21回全国原発性肝癌追跡調査においては、546施設から2010年1月1日から2011年12月31日までの2年間の22,134例の新規症例と41,956例の追跡症例が集計された。基礎統計は、第21回新規登録症例を対象として死因、既往歴、臨床診断、画像診断、治療法別の各因子、病理診断、再発、剖検についてまとめた。第20回調査と比較し、肝細胞癌における臨床診断時の高齢化、女性の増加、非B非C肝癌の増加、腫瘍径の縮小の傾向が、治療においては切除の割合の増加、局所療法におけるラジオ波焼灼療法の増加が認められた。1998年から2011年まで新規登録症例の中で最終予後が生存または死亡となった症例(不明を除く)について肝細胞癌、肝内胆管癌、混合型肝癌の治療法別、背景因子別累積生存率を算出した。肝細胞癌については腫瘍個数、腫瘍径、肝障害度、Child-Pugh分類を組み合わせることにより背景因子を揃えて、治療法別(肝切除、局所療法、肝動脈塞栓療法(TACE))、肝動注化学療法の累積生存率を算出し、また、1978年から2011年までの新規登録症例を4期に分け、累積生存率を算出した。新規登録症例数は経時的に増加し、肝細胞癌の予後の改善が著しいことが明らかとなった。本追跡調査が原発性肝癌の研究および診療の進歩に役立つことを期待する。(著者抄録)
    (一社)日本肝臓学会, 2020年12月, 肝臓, 61(12) (12), 645 - 691, 日本語

  • 工藤 正俊, 泉 並木, 久保 正二, 國土 典宏, 坂元 亨宇, 椎名 秀一朗, 高山 忠利, 建石 良介, 中島 収, 村上 卓道, 松山 裕, 高橋 新, 宮田 裕章, 田村 利恵, 上妻 智子, 日本肝癌研究会追跡調査委員会
    第21回全国原発性肝癌追跡調査においては、546施設から2010年1月1日から2011年12月31日までの2年間の22,134例の新規症例と41,956例の追跡症例が集計された。基礎統計は、第21回新規登録症例を対象として死因、既往歴、臨床診断、画像診断、治療法別の各因子、病理診断、再発、剖検についてまとめた。第20回調査と比較し、肝細胞癌における臨床診断時の高齢化、女性の増加、非B非C肝癌の増加、腫瘍径の縮小の傾向が、治療においては切除の割合の増加、局所療法におけるラジオ波焼灼療法の増加が認められた。1998年から2011年まで新規登録症例の中で最終予後が生存または死亡となった症例(不明を除く)について肝細胞癌、肝内胆管癌、混合型肝癌の治療法別、背景因子別累積生存率を算出した。肝細胞癌については腫瘍個数、腫瘍径、肝障害度、Child-Pugh分類を組み合わせることにより背景因子を揃えて、治療法別(肝切除、局所療法、肝動脈塞栓療法(TACE))、肝動注化学療法の累積生存率を算出し、また、1978年から2011年までの新規登録症例を4期に分け、累積生存率を算出した。新規登録症例数は経時的に増加し、肝細胞癌の予後の改善が著しいことが明らかとなった。本追跡調査が原発性肝癌の研究および診療の進歩に役立つことを期待する。(著者抄録)
    (一社)日本肝臓学会, 2020年12月, 肝臓, 61(12) (12), 645 - 691, 日本語

  • Horinouchi H, Ueshima E, Sofue K, Komatsu S, Okada T, Yamaguchi M, Fukumoto T, Sugimoto K, Murakami T
    BACKGROUND: Postoperative biliary strictures are commonly related to accidental bile duct injuries or occur at the site of biliary anastomosis. The first-line treatment for benign biliary strictures is endoscopic therapy, which is less invasive and repeatable. However, recanalization for biliary complete obstruction is technically challenging to treat. The present report describes a successful case of treatment by extraluminal recanalization for postoperative biliary obstruction using a transseptal needle. CASE PRESENTATION: A 66-year-old woman had undergone caudal lobectomy for the treatment of hepatocellular carcinoma. The posterior segmental branch of the bile duct was injured and repaired intraoperatively. Three months after the surgery, the patient had developed biliary leakage from the right hepatic bile duct, resulting in complete biliary obstruction. Since intraluminal recanalization with conventional endoscopic and percutaneous approaches with a guidewire failed, extraluminal recanalization using a transseptal needle with an internal lumen via percutaneous approach was performed under fluoroscopic guidance. The left lateral inferior segmental duct was punctured, and an 8-F transseptal sheath was introduced into the ostium of right hepatic duct. A transseptal needle was advanced, and the right hepatic duct was punctured by targeting an inflated balloon that was placed at the end of the obstructed right hepatic bile duct. After confirming successful puncture using contrast agent injected through the internal lumen of the needle, a 0.014-in. guidewire was advanced into the right hepatic duct. Finally, an 8.5-F internal-external biliary drainage tube was successfully placed without complications. One month after the procedure, the drainage tube was replaced with a 10.2-F drainage tube to dilate the created tract. Subsequent endoscopic internalization was performed 5 months after the procedure. At the 1-year follow-up examination, there was no sign of biliary obstruction and recurrence of hepatocellular carcinoma. CONCLUSIONS: Recanalization using a transseptal needle can be an alternative technique for rigid biliary obstruction when conventional techniques fail.
    2020年12月, Surgical case reports, 6(1) (1), 304 - 304, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Matsuo H, Nishio M, Kanda T, Kojita Y, Kono A, Hori M, Teshima M, Otsuki N, Nibu K, Murakami T
    Abstract We hypothesized that, in discrimination between benign and malignant parotid gland tumors, high diagnostic accuracy could be obtained with a small amount of imbalanced data when anomaly detection (AD) was combined with deep leaning (DL) model and the L2-constrained softmax loss. The purpose of this study was to evaluate whether the proposed method was more accurate than other commonly used DL or AD methods. Magnetic resonance (MR) images of 245 parotid tumors (22.5% malignant) were retrospectively collected. We evaluated the diagnostic accuracy of the proposed method (VGG16-based DL and AD) and that of classification models using conventional DL and AD methods. A radiologist also evaluated the MR images. ROC and precision-recall (PR) analyses were performed, and the area under the curve (AUC) was calculated. In terms of diagnostic performance, the VGG16-based model with the L2-constrained softmax loss and AD (local outlier factor) outperformed conventional DL and AD methods and a radiologist (ROC-AUC = 0.86 and PR-ROC = 0.77). The proposed method could discriminate between benign and malignant parotid tumors in MR images even when only a small amount of data with imbalanced distribution is available.
    Springer Science and Business Media LLC, 2020年12月, Scientific Reports, 10(1) (1), 19388 - 19388, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Nishio M, Noguchi S, Matsuo H, Murakami T
    Abstract This study aimed to develop and validate computer-aided diagnosis (CXDx) system for classification between COVID-19 pneumonia, non-COVID-19 pneumonia, and the healthy on chest X-ray (CXR) images. From two public datasets, 1248 CXR images were obtained, which included 215, 533, and 500 CXR images of COVID-19 pneumonia patients, non-COVID-19 pneumonia patients, and the healthy samples, respectively. The proposed CADx system utilized VGG16 as a pre-trained model and combination of conventional method and mixup as data augmentation methods. Other types of pre-trained models were compared with the VGG16-based model. Single type or no data augmentation methods were also evaluated. Splitting of training/validation/test sets was used when building and evaluating the CADx system. Three-category accuracy was evaluated for test set with 125 CXR images. The three-category accuracy of the CAD system was 83.6% between COVID-19 pneumonia, non-COVID-19 pneumonia, and the healthy. Sensitivity for COVID-19 pneumonia was more than 90%. The combination of conventional method and mixup was more useful than single type or no data augmentation method. In conclusion, this study was able to create an accurate CADx system for the 3-category classification. Source code of our CADx system is available as open source for COVID-19 research.
    Springer Science and Business Media LLC, 2020年12月, Scientific Reports, 10(1) (1), 17532
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Akamine Y, Ueda Y, Ueno Y, Sofue K, Murakami T, Yoneyama M, Obara M, Cautere MV
    PURPOSE: Hierarchical clustering (HC), an unsupervised machine learning (ML) technique, was applied to multi-parametric MR (mp-MR) for prostate cancer (PCa). The aim of this study is to demonstrate HC can diagnose PCa in a straightforward interpretable way, in contrast to deep learning (DL) techniques. METHODS: HC was constructed using mp-MR including intravoxel incoherent motion, diffusion kurtosis imaging, and dynamic contrast-enhanced MRI from 40 tumor and normal tissues in peripheral zone (PZ) and 23 tumor and normal tissues in transition zone (TZ). HC model was optimized by assessing the combinations of several dissimilarity and linkage methods. Goodness of HC model was validated by internal methods. RESULTS: Accuracy for differentiating tumor and normal tissue by optimal HC model was 96.3% in PZ and 97.8% in TZ, comparable to current clinical standards. Relationship between input (DWI and permeability parameters) and output (tumor and normal tissue cluster) was shown by heat maps, consistent with literature. CONCLUSION: HC can accurately differentiate PCa and normal tissue, comparable to state-of-the-art diffusion based parameters. Contrary to DL techniques, HC is an operator-independent ML technique producing results that can be interpreted such that the results can be knowledgeably judged.
    Elsevier BV, 2020年12月, Magnetic Resonance Imaging, 74, 90 - 95, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • 急性上腸間膜動脈閉塞症のIVR 塞栓症と動脈解離
    小出 裕, 松代 啓吾, 丸山 晃司, 川崎 竜太, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, 2020年10月, 日本医学放射線学会秋季臨床大会抄録集, 56回, S67 - S67, 日本語

  • 腹部人工血管置換術後遠隔期に被覆瘤外への出血に対し経動脈的塞栓術を行った2例
    松代 啓吾, 川崎 竜太, 小出 裕, 丸山 晃司, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, 2020年10月, 日本医学放射線学会秋季臨床大会抄録集, 56回, S145 - S145, 日本語

  • 外傷性上腕動脈損傷に対しステント留置術を施行した1例
    伊崎 健太, 木下 知恵子, 酒井 英郎, 池田 覚, 佐野 秀, 当广 美樹, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, 2020年10月, 日本医学放射線学会秋季臨床大会抄録集, 56回, S147 - S147, 日本語

  • 孤立性上腸間膜動脈解離に対しステント留置術を行った難渋例
    小出 裕, 松代 啓吾, 丸山 晃司, 川崎 竜太, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, 2020年10月, 日本医学放射線学会秋季臨床大会抄録集, 56回, S147 - S147, 日本語

  • 胸部PET/MRIの吸収補正 別症例のCTを用いてZTEから偽CTを深層学習により作成する検討
    野上 宗伸, 松尾 秀俊, 西尾 瑞穂, 曽 菲比, 犬養 純子, Wiesinger Florian, Kaushik Sandeep, 栗本 貴子, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2020年10月, 核医学, 57(Suppl.) (Suppl.), S157 - S157, 英語

  • 中咽頭腫瘍として発症したGiant cell tumor of tendon sheath
    小路田 泰之, 神田 知紀, 村上 卓道
    (公社)日本医学放射線学会, 2020年10月, 日本医学放射線学会秋季臨床大会抄録集, 56回, S134 - S134, 日本語

  • 肺病変に関するPET/MRIにおけるZero-TE法の診断能について
    Zeng Feibi, 野上 宗伸, 犬養 純子, 上野 嘉子, 神田 知紀, 祖父江 慶太郎, 久保 和広, 栗本 貴子, 村上 卓道
    (一社)日本核医学会, 2020年10月, 核医学, 57(Suppl.) (Suppl.), S155 - S155, 英語

  • 悪性腫瘍の全身FDG PET/MRIにおけるBSREMを用いた高速撮像と診断能の検討
    犬養 純子, 野上 宗伸, 曽 菲比, 渡邊 慶明, 西尾 瑞穂, 神田 知紀, 祖父江 慶太郎, 河野 敦, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2020年10月, 核医学, 57(Suppl.) (Suppl.), S174 - S174, 日本語

  • 肺病変に関するPET/MRIにおけるZero-TE法の診断能について
    Zeng Feibi, 野上 宗伸, 犬養 純子, 上野 嘉子, 神田 知紀, 祖父江 慶太郎, 久保 和広, 栗本 貴子, 村上 卓道
    (一社)日本核医学会, 2020年10月, 核医学, 57(Suppl.) (Suppl.), S155 - S155, 英語

  • 胸部PET/MRIの吸収補正 別症例のCTを用いてZTEから偽CTを深層学習により作成する検討
    野上 宗伸, 松尾 秀俊, 西尾 瑞穂, 曽 菲比, 犬養 純子, Wiesinger Florian, Kaushik Sandeep, 栗本 貴子, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2020年10月, 核医学, 57(Suppl.) (Suppl.), S157 - S157, 英語

  • 悪性腫瘍の全身FDG PET/MRIにおけるBSREMを用いた高速撮像と診断能の検討
    犬養 純子, 野上 宗伸, 曽 菲比, 渡邊 慶明, 西尾 瑞穂, 神田 知紀, 祖父江 慶太郎, 河野 敦, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2020年10月, 核医学, 57(Suppl.) (Suppl.), S174 - S174, 日本語

  • 急性上腸間膜動脈閉塞症のIVR 塞栓症と動脈解離
    小出 裕, 松代 啓吾, 丸山 晃司, 川崎 竜太, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, 2020年10月, 日本医学放射線学会秋季臨床大会抄録集, 56回, S67 - S67, 日本語

  • 治療適応の基準を満たさない腎血管筋脂肪腫の破裂
    元津 倫幸, 山口 雅人, 佐々木 康二, Hamada M.A.S., 上嶋 英介, 岡田 卓也, 祖父江 慶太郎, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, 2020年10月, 日本医学放射線学会秋季臨床大会抄録集, 56回, S144 - S144, 日本語

  • 腹部人工血管置換術後遠隔期に被覆瘤外への出血に対し経動脈的塞栓術を行った2例
    松代 啓吾, 川崎 竜太, 小出 裕, 丸山 晃司, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, 2020年10月, 日本医学放射線学会秋季臨床大会抄録集, 56回, S145 - S145, 日本語

  • 外傷性上腕動脈損傷に対しステント留置術を施行した1例
    伊崎 健太, 木下 知恵子, 酒井 英郎, 池田 覚, 佐野 秀, 当广 美樹, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, 2020年10月, 日本医学放射線学会秋季臨床大会抄録集, 56回, S147 - S147, 日本語

  • 孤立性上腸間膜動脈解離に対しステント留置術を行った難渋例
    小出 裕, 松代 啓吾, 丸山 晃司, 川崎 竜太, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, 2020年10月, 日本医学放射線学会秋季臨床大会抄録集, 56回, S147 - S147, 日本語

  • Numoto I, Tsurusaki M, Oda T, Yagyu Y, Ishii K, Murakami T
    PURPOSE: To evaluate the efficacy and safety of transcatheter arterial embolization (TAE) for pseudoaneurysms occurring secondary to pancreatitis or because of leakage of pancreatic juice after pancreatectomy. MATERIALS AND METHODS: This retrospective study included 42 consecutive patients (38 males and 4 females; mean age, 60 years; range, 33-80 years) who underwent TAE for bleeding visceral artery pseudoaneurysms between March 2004 and December 2018. The technical and clinical success rates, incidence of recurrent bleeding, complications, including pancreatitis, and overall survival after TAE were evaluated. RESULTS: Of the 42 enrolled patients, 23 had bleeding due to a complication of pancreatectomy and 19 had bleeding as a complication of pancreatitis. TAE with N-butyl cyanoacrylate (NBCA) or NBCA plus microcoils recurrent bleeding or inability to control bleeding was 15.8% (3 of 19) following TAE with NBCA and 17.4% (4 of 23) following TAE with coils. No clinically significant ischemic events of the pancreas or duodenum were observed in the embolized areas. Serum amylase did not increase compared with the initial levels after any of the procedures. At 30 days after TAE, 32 patients were alive. CONCLUSION: TAE has a high success rate for the management of hemorrhage, with few complications. The procedure appears to be safe and effective for pseudoaneurysms associated with either pancreatitis or pancreatectomy.
    2020年09月, Cancers, 12(10) (10), 2733 - 2733, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Tsujita Y, Sofue K, Komatsu S, Yamaguchi T, Ueshima E, Ueno Y, Kanda T, Okada T, Nogami M, Yamaguchi M, Tsurusaki M, Hori M, Fukumoto T, Murakami T
    PURPOSE: Accurate prediction of post-hepatectomy liver failure (PHLF) is important in advanced hepatocellular carcinoma (HCC). We aimed to retrospectively evaluate the utility of gadoxetic acid-enhanced MRI for predicting PHLF in patients who underwent anatomic hepatectomy for HCC with portal vein invasion. METHODS: Forty-one patients (32 men, 9 women) were included. Hepatobiliary-phase MR images were acquired 20 min after injection of gadoxetic acid using a 3D fat-suppressed T1-weighted spoiled gradient-echo sequence. Liver-spleen ratio (LSR), remnant hepatocellular uptake index (rHUI), and HUI were calculated. The severity of PHLF was defined according to the International Study Group of Liver Surgery. Differences in LSR between the resected liver and the remnant liver, and HUI and rHUI/HUI between no/mild and severe PHLF were compared using the Wilcoxon signed-rank test and Wilcoxon rank-sum test, respectively. Univariate and multivariate logistic regression analyses were performed to identify predictors of severe PHLF. Areas under the receiver operating characteristic curves (AUCs) of rHUI and rHUI/HUI were calculated for predicting severe PHLF. RESULTS: Nine patients developed severe PHLF. LSR of the remnant liver was significantly higher than that of the resected liver (P < 0.001). Severe PHLF demonstrated significantly lower rHUI (P < 0.001) and rHUI/HUI (P < 0.001) compared with no/mild PHLF. Multivariate logistic regression analysis showed that decreased rHUI (P = 0.012, AUC=0.885) and rHUI/HUI (P = 0.002, AUC=0.852) were independent predictors of severe PHLF. CONCLUSION: Gadoxetic acid-enhanced MRI can be a promising noninvasive examination for assessing global and regional liver function, allowing estimation of the functional liver remnant and accurate prediction of severe PHLF before hepatic resection.
    2020年09月, European journal of radiology, 130, 109189 - 109189, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • メトホルミンは消化管内腔へのFluorode-oxyglucose(FDG)排泄を促進させる
    森田 靖子, 野上 宗伸, 坂口 一彦, 岡田 裕子, 廣田 勇士, 田守 義和, 曽 菲比, 村上 卓道, 小川 渉
    (一社)日本糖尿病学会, 2020年08月, 糖尿病, 63(Suppl.1) (Suppl.1), S - 115, 日本語

  • アンギオ室での急変対応におけるチーム医療 ハートフルチームビルディング
    小出 裕, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2020年08月, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 136 - 136, 日本語

  • EVAR後の瘤径拡大例に対するトラネキサム酸投与の有用性
    松代 啓吾, 川崎 竜太, 丸山 晃司, 小出 裕, 野村 佳克, 山口 雅人, 岡田 卓也, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2020年08月, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 166 - 166, 日本語

  • 腎動脈瘤に対しバイアバーンを留置した1例
    伊崎 健太, 木下 知恵子, 池田 覚, 酒井 英郎, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2020年08月, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 252 - 253, 日本語

  • 骨転移の痛みのマネージメント 脊椎転移に対する経皮的椎体形成術の適応について考える
    岡田 卓也, 佐々木 康二, 角谷 賢一朗, 宮脇 大輔, 酒井 良忠, 坂下 明大, 今村 善宣, 山口 雅人, 杉本 幸司, 村上 卓道
    (NPO)日本緩和医療学会, 2020年08月, Palliative Care Research, 15(Suppl.) (Suppl.), S37 - S37, 日本語

  • 液体塞栓物質(NBCA)を極める! エキスパートへの道 膵領域の急性出血に対するNBCAを用いた動脈塞栓術の検討
    佐々木 康二, 岡田 卓也, 山口 雅人, Hamada Mostafa, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2020年08月, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 122 - 122, 日本語

  • 骨転移疼痛に対する集学的治療 -この痛みをどう治療するか- 骨転移に対する骨セメント治療 経皮的椎体形成術の適応を考える
    岡田 卓也, 佐々木 康二, Hamada M.A.S., 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2020年08月, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 131 - 131, 日本語

  • 大動脈解離に対するIVR 大動脈解離に対するIVRの現況と課題
    山口 雅人, 岡田 卓也, 佐々木 康二, 元津 倫幸, 上嶋 英介, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2020年08月, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 133 - 133, 日本語

  • ドセタキセル含浸薬剤溶出性ビーズの基礎的検討
    谷 龍一郎, 岡田 卓也, 上嶋 英介, 篠原 正和, 元津 倫幸, 佐々木 康二, Hamada M.A.S, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2020年08月, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 282 - 282, 日本語

  • Yamada Y, Masuda A, Sofue K, Murakami T, Kodama Y
    Background and Aims: Imaging tools for predicting pancreatic atrophy after steroid therapy in autoimmune pancreatitis (AIP) have not been established. As delayed equilibrium-phase contrast enhancement in computed tomography (CE-CT) may reflect interstitial fibrosis, we evaluated the ability of equilibrium-phase CT imaging for predicting pancreatic atrophy. Methods: Forty-six steroid-treated AIP patients who underwent contrast-enhanced CT at our university hospital were included in this retrospective study. CT attenuation (Hounsfield units [HU]) values in noncontrast images (NC) and equilibrium-phase images (EP) and the differences in HU values between NC and EP images (SUB) were measured. Pancreatic volume was measured in CE-CT before (Volpre) and after (Volpost) steroid therapy. The volume reduction rate was calculated. The relationships of CT values with pancreatic atrophy, Volpost, volume reduction rate, and diabetes exacerbation were investigated. Results: CT values in the EP and SUB images before steroid therapy were associated with pancreatic atrophy after steroid therapy (atrophy vs nonatrophy 114.5 ± 12.8 vs 99.5 ± 11.1, P = 0.0002; 70.9 ± 14.72 vs 57.2 ± 13.1, P = 0.003, respectively), but CT values in NC images were not (P = 0.42). CT values in EP and SUB images before steroid therapy were correlated with Volpost (EP images r = -0.70, P = 0.002; SUB images r = -0.68, P = 0.03) and volume reduction rate after steroid therapy (EP images: r = -0.55, P < 0.0001; SUB images r = -0.45, P = 0.002). Diabetes exacerbation was associated with higher EP and SUB values (P = 0.009 and P = 0.04, respectively). Conclusion: Equilibrium-phase contrast CT imaging may facilitate prediction of pancreatic atrophy after steroid therapy in AIP.
    2020年08月, JGH open : an open access journal of gastroenterology and hepatology, 4(4) (4), 677 - 683, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Ueno Y, Tamada T, Takeuchi M, Sofue K, Takahashi S, Kamishima Y, Urase Y, Kido A, Hinata N, Harada K, Fujisawa M, Miyaji Y, Murakami T
    American Roentgen Ray Society, 2020年07月, American Journal of Roentgenology[Epub ahead of print]
    [査読有り]
    研究論文（学術雑誌）

  • Morita Y, Nogami M, Sakaguchi K, Okada Y, Hirota Y, Sugawara K, Tamori Y, Zeng F, Murakami T, Ogawa W
    OBJECTIVE: Positron emission tomography (PET)-computed tomography has revealed that metformin promotes the intestinal accumulation of [18F]fluorodeoxyglucose (FDG), a nonmetabolizable glucose derivative. It has remained unknown, however, whether this accumulation occurs in the wall or intraluminal space of the intestine. We here addressed this question with the use of [18F]FDG PET-MRI, a recently developed imaging method with increased accuracy of registration and high soft-tissue contrast. RESEARCH DESIGN AND METHODS: Among 244 individuals with type 2 diabetes who underwent PET-MRI, we extracted 24 pairs of subjects matched for age, BMI, and HbA1c level who were receiving treatment with metformin (metformin group) or were not (control group). We evaluated accumulation of [18F]FDG in different portions of the intestine with both a visual scale and measurement of maximum standardized uptake value (SUVmax), and such accumulation within the intestinal wall or lumen was discriminated on the basis of SUVmax. RESULTS: SUVmax of the jejunum, ileum, and right or left hemicolon was greater in the metformin group than in the control group. [18F]FDG accumulation in the ileum and right or left hemicolon, as assessed with the visual scale, was also greater in the metformin group. SUVmax for the intraluminal space of the ileum and right or left hemicolon, but not that for the intestinal wall, was greater in the metformin group than in the control group. CONCLUSIONS: Metformin treatment was associated with increased accumulation of [18F]FDG in the intraluminal space of the intestine, suggesting that this drug promotes the transport of glucose from the circulation into stool.
    2020年07月, Diabetes Care, 43(7) (7), 1 - 7, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Yasuyo Urase, Mizuho Nishio, Yoshiko Ueno, Atsushi K. Kono, Keitaro Sofue, Tomonori Kanda, Takaki Maeda, Munenobu Nogami, Masatoshi Hori, Takamichi Murakami
    The usefulness of sparse-sampling CT with deep learning-based reconstruction for detection of metastasis of malignant ovarian tumors was evaluated. We obtained contrast-enhanced CT images (n = 141) of ovarian cancers from a public database, whose images were randomly divided into 71 training, 20 validation, and 50 test cases. Sparse-sampling CT images were calculated slice-by-slice by software simulation. Two deep-learning models for deep learning-based reconstruction were evaluated: Residual Encoder-Decoder Convolutional Neural Network (RED-CNN) and deeper U-net. For 50 test cases, we evaluated the peak signal-to-noise ratio (PSNR) and structural similarity (SSIM) as quantitative measures. Two radiologists independently performed a qualitative evaluation for the following points: entire CT image quality; visibility of the iliac artery; and visibility of peritoneal dissemination, liver metastasis, and lymph node metastasis. Wilcoxon signed-rank test and McNemar test were used to compare image quality and metastasis detectability between the two models, respectively. The mean PSNR and SSIM performed better with deeper U-net over RED-CNN. For all items of the visual evaluation, deeper U-net scored significantly better than RED-CNN. The metastasis detectability with deeper U-net was more than 95%. Sparse-sampling CT with deep learning-based reconstruction proved useful in detecting metastasis of malignant ovarian tumors and might contribute to reducing overall CT-radiation exposure.
    MDPI AG, 2020年06月, Applied Sciences, 10(13) (13), 4446 - 4446
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Horinouchi H, Okada T, Yamaguchi M, Maruyama K, Sasaki K, Gentsu T, Ueshima E, Sofue K, Kawasaki R, Nomura Y, Omura A, Okada K, Sugimoto K, Murakami T
    PURPOSE: To evaluate the mid-term outcomes of transarterial embolization (TAE) for type II endoleak after endovascular abdominal aortic aneurysm repair (EVAR) and investigate the predictors of sac enlargement after embolization. MATERIALS AND METHODS: We conducted a retrospective analysis of 55 patients [48 men and 7 women, median age 79.0 (interquartile ranges 74-82) years] who underwent TAE for type II endoleak from 2010 to 2018. The aneurysmal sac enlargement, endoleaks, aneurysm-related adverse event rate, and reintervention rate were evaluated. Patients' characteristics and clinical factors were evaluated for their association with sac enlargement. RESULTS: Fifty-five patients underwent TAE with technical success and were subsequently followed for a median of 636 (interquartile ranges 446-1292) days. The freedom from sac enlargement rates at 1, 3, and 5 years was 73.2%, 32.0%, and 26.7%, respectively. After initial TAE, the recurrent type II, delayed type I, and occult type III endoleak were identified in 39 (71%), 5 (9%), and 3 (5%) patients, respectively. Although a patient had aorto-duodenal fistula, there was no aneurysm-related death. The freedom from reintervention rates was 84.6%, 35.7%, and 17.0%, respectively. In the multivariate analysis, sac diameter > 55 mm at initial TAE (hazard ratios, 3.23; 95% confidence intervals, 1.22-8.58; P < 0.05) was a significant predictor of sac enlargement. CONCLUSION: TAE for type II endoleak was not effective in preventing sac enlargement, and reinterventions were required among the mid-term follow-up. The sac diameter > 55 mm at initial TAE was a significant predictor of sac enlargement.
    2020年05月, Cardiovascular and interventional radiology, 43(5) (5), 696 - 705, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Horinouchi H, Sofue K, Nishii T, Maruyama K, Sasaki K, Gentsu T, Ueshima E, Okada T, Yamaguchi M, Sugimoto K, Murakami T
    PURPOSE: To assess the utility of whole-aorta CT angiography (CTA) with 15 mL contrast material (CM) on time-resolved imaging for endovascular abdominal aortic repair (EVAR). METHODS: Twenty-six patients with a high-risk of post-contrast acute kidney injury (PC-AKI) underwent CTA with 15 mL CM using temporal maximum intensity projection (tMIP-CTA) generated from time-resolved imaging. The aortoiliac CT values were measured. Two observers measured the arterial diameters in unenhanced CT and tMIP-CTA images, and image quality was evaluated on a 5-point scale. The presence of the accessory renal artery, inferior mesenteric artery (IMA) occlusion, and instructions for use (IFU) of EVAR were evaluated. RESULTS: CT examinations were successfully performed, and no patients developed PC-AKI. The mean CT values of the whole aorta were 267.5 ± 51.4 HU, which gradually decreased according to the distal levels of the aorta. Bland-Altman analysis revealed excellent agreement for the external arterial diameter measurements between unenhanced CT and tMIP-CTA. Excellent interobserver agreement was achieved for the measurements of the external (ICCs, 0.910-0.992) and internal arterial diameters (ICCs, 0.895-0.993). Excellent or good overall image quality was achieved in 24 (92 %) patients. The presence of the accessory renal artery, IMA occlusion and the assessment of IFU were in 100 % agreement. Multivariate analysis revealed aortic volume as the most significant independent factor associated with strong aortic enhancement (p = 0.004). CONCLUSIONS: Whole-aorta tMIP-CTA on time-resolved imaging is useful for maintaining contrast enhancement and image quality for EVAR planning, and can substantially reduce the amount of CM.
    2020年05月, European journal of radiology, 126, 108861 - 108861, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Zeng F, Nogami M, Ueno Y R, Kanda T, Sofue K, Kubo K, Kurimoto T, Murakami T
    OBJECTIVES: This study aimed to evaluate the diagnostic performance of the lung zero-echo time (ZTE) sequence in FDG PET/MRI for detection and differentiation of lung lesions in oncologic patients in comparison with conventional two-point Dixon-based MR imaging. METHODS: In this single-institution retrospective study approved by the institutional review board, 209 patients with malignancies (97 men and 112 women; age range, 17-89 years; mean age, 66.5 ± 12.9 years) underwent 18F-FDG PET/MRI between August 2017 and August 2018, with diagnostic Dixon and ZTE under respiratory gating acquired simultaneously with PET. Image analysis was performed for PET/Dixon and PET/ZTE fused images by two readers to assess the detectability and differentiation of lung lesions. The reference standard was pathological findings and/or the data from a chest CT. The detection and differentiation abilities were evaluated for all lesions and subgroups divided by lesion size and maximum standardized uptake value (SUVmax). RESULTS: Based on the reference standard, 227 lung lesions were identified in 113 patients. The detectability of PET/ZTE was significantly better than that of PET/Dixon for overall lesions, lesions with a SUVmax less than 3.0 and lesions smaller than 4 mm (p < 0.01). The diagnostic performance of PET/ZTE was significantly better than that of PET/Dixon for overall lesions and lesions smaller than 4 mm (p < 0.01). CONCLUSIONS: ZTE can improve diagnostic performance in the detection and differentiation of both FDG-avid and non-FDG-avid lung lesions smaller than 4 mm in size, yielding a promising tool to enhance the utility of FDG PET/MRI in oncology patients with lung lesions. KEY POINTS: • The detection rate of PET/ZTE for lesions with a SUVmax of less than 1.0 was significantly better than that of PET/Dixon. • The performance for differentiation of PET/ZTE for lesions that were even smaller than 4 mm in size were significantly better than that of PET/Dixon. • Inter-rater agreement of PET/ZTE for the differentiation of lesions less than 4 mm in size was substantial and better than that of PET/Dixon.
    2020年04月, European Radiology, 30(9) (9), 4995 - 5003, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Tai K, Komatsu S, Sofue K, Kido M, Tanaka M, Kuramitsu K, Awazu M, Gon H, Tsugawa D, Yanagimoto H, Toyama H, Murakami S, Murakami T, Fukumoto T
    BACKGROUND: Although total tumour volume (TTV) may have prognostic value for hepatic resection in certain solid cancers, its importance in colorectal liver metastases (CRLM) remains unexplored. This study investigated its prognostic value in patients with resectable CRLM. METHOD: This was a retrospective review of patients who underwent hepatic resection for CRLM between 2008 and 2017 in a single institution. TTV was measured from CT images using three-dimensional construction software; cut-off values were determined using receiver operating characteristic (ROC) curve analyses. Potential prognostic factors, overall survival (OS) and recurrence-free survival (RFS) were determined using multivariable and Kaplan-Meier analyses. RESULTS: Some 94 patients were included. TTV cut-off values for OS and RFS were 100 and 10 ml respectively. Right colonic primary tumours, primary lymph node metastasis and bilobar liver metastasis were included in the multivariable analysis of OS; a TTV of 100 ml or above was independently associated with poorer OS (hazard ratio (HR) 6·34, 95 per cent c.i. 2·08 to 17·90; P = 0·002). Right colonic primary tumours and primary lymph node metastasis were included in the RFS analysis; a TTV of 10 ml or more independently predicted poorer RFS (HR 1·90, 1·12 to 3·57; P = 0·017). The 5-year OS rate for a TTV of 100 ml or more was 41 per cent, compared with 67 per cent for a TTV below 100 ml (P = 0·006). Corresponding RFS rates with TTV of 10 ml or more, or less than 10 ml, were 14 and 58 per cent respectively (P = 0·009). A TTV of at least 100 ml conferred a higher rate of unresectable initial recurrences (12 of 15, 80 per cent) after initial hepatic resection. CONCLUSION: TTV was associated with RFS and OS after initial hepatic resection for CRLM; TTV of 100 ml or above was associated with a higher rate of unresectable recurrence.
    2020年04月, BJS open, 4(3) (3), 456 - 466, 英語, 国際誌
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Sofue K, Onoda M, Tsurusaki M, Morimoto D, Yada N, Kudo M, Murakami T
    BACKGROUND: Differentiation between inflammation and fibrosis is an important clinical distinction in patients with chronic liver disease, which has been difficult so far with MR elastography. PURPOSE: To investigate whether dual-frequency MR elastography can estimate necroinflammation of the liver and improve diagnostic performance for the staging of liver fibrosis. STUDY TYPE: Retrospective. SUBJECTS: In all, 30 patients (14 males, 16 females) with chronic liver disease. FIELD STRENGTH/SEQUENCE: 1.5T/dual-frequency MR elastography at 60-Hz and 80-Hz vibration frequencies. [Correction added on November 12, 2019, after first online publication: The field strength in the preceding sentence was corrected.] ASSESSMENT: Necroinflammation activity and fibrosis were assessed using the METAVIR scoring system. Stiffness values at 60-Hz (G60-Hz ) and 80-Hz (G80-Hz ) were obtained with an MR elastogram. The difference value between G80-Hz and G60-Hz (ΔG) was calculated. Four values (G60-Hz , G80-Hz , G60-Hz - ΔG, and G80-Hz  + ΔG) were generated to estimate necroinflammation and fibrosis. STATISTICAL TESTS: The ΔG were correlated with necroinflammation activity grade and fibrosis stage using Spearman's rank correlation. Diagnostic performance of the four values for necroinflammation activity grade and fibrous stage was assessed by using area under the receiver operating characteristic curve (AUC). RESULTS: The mean value of G80-Hz (6.23 ± 3.67 kPa) was significantly higher than that of G60-Hz (5.27 ± 3.14 kPa) (P < 0.0001). The ΔG demonstrated a strong correlation with necroinflammation grade (ρ = 0.625, P < 0.001) and no correlation with fibrosis stage (ρ = 0.306, P = 0.113). The AUC of the G80-Hz and G80-Hz  + ΔG showed higher accuracy for necroinflammation, and optimal cutoff values yielded better discrimination of ≥A1, ≥A2, and = A3. The AUC demonstrated that all the generated values had high diagnostic performance (≥0.87 for all) for fibrosis. DATA CONCLUSION: Dual-frequency MR elastography shows potential in estimating necroinflammation of the liver and may improve diagnostic performance for staging liver fibrosis. LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:1053-1064.
    2020年04月, Journal of magnetic resonance imaging : JMRI, 51(4) (4), 1053 - 1064, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Komatsu S, Yano Y, Sofue K, Kido M, Tanaka M, Kuramitsu K, Awazu M, Gon H, Yamamoto A, Yanagimoto H, Toyama H, Kodama Y, Murakami T, Fukumoto T
    BACKGROUND: The present study aimed to assess the clinical features of patients who received lenvatinib treatment for unresectable hepatocellular carcinoma (HCC). METHODS: The clinical characteristics, adverse events, and radiological responses were evaluated for 51 consecutive patients. RESULTS: Of the study subjects, 37 patients had Child-Pugh class A (CPA) liver function, and 14 patients had Child-Pugh class B (CPB) liver function. The overall response rates in the CPA and CPB groups were 42.9% and 25.0%, respectively, and disease control rates were 82.9% and 83.3%, respectively, without significant difference (p = 0.2621 and 0.9697). There was no significant difference between CPA and CPB groups regarding the incidence of adverse events, except for hepatic coma. No significant difference was observed in the relative dose intensity between the CPA and CPB groups, for the first month, 1-2 months, or 2-3 months (p = 0.2368, 0.9368, and 0.9293). CONCLUSION: The comparable outcomes between the CPA and CPB groups suggest the acceptability of lenvatinib treatment in patients with impaired liver function, at least in the acute phase. With careful follow-up, the dose can be relatively intensified, even in patients with impaired liver function and this may contribute to offering comparable treatment.
    2020年03月, HPB : the official journal of the International Hepato Pancreato Biliary Association[Epub ahead of print], 22(10) (10), 1450 - 1456, 英語, 国際誌
    研究論文（学術雑誌）

  • 子宮広間膜に発生した平滑筋肉腫の1例
    宮崎 亜樹, 上野 嘉子, 田中 宇多留, 祖父江 慶太郎, 村上 卓道, 原 重雄, 藤倉 航平, 伊藤 智雄, 蝦名 康彦, 山田 秀人, 前田 哲雄
    (公社)日本医学放射線学会, 2020年02月, Japanese Journal of Radiology, 38(Suppl.) (Suppl.), 38 - 38, 日本語

  • 線維軟骨塞栓症が疑われた若年者脊髄梗塞の1例
    藤原 康弘, 神田 知紀, 上野 嘉子, 岡田 卓也, 祖父江 慶太郎, 前田 隆樹, 野上 宗伸, 山口 雅人, 杉本 幸司, 村上 卓道, 大塚 喜久
    (公社)日本医学放射線学会, 2020年02月, Japanese Journal of Radiology, 38(Suppl.) (Suppl.), 40 - 40, 日本語
    [査読有り]

  • Kanda T, Miyazaki A, Zeng F, Ueno Y, Sofue K, Maeda T, Nogami M, Kitajima K, Murakami T
    The optic nerve is morphologically classified as a peripheral nerve, but histologically it shares characteristics with the central nerves. Diseases that affect vision and the optic nerve are many and varied: optic neuritis, demyelination (multiple sclerosis, acute disseminated encephalomyelitis, neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody-related disorders), drugs, collagen disease, vasculitis, infection, trauma, vascular abnormalities, tumours, and non-tumoural masses. In this review, we summarise the magnetic resonance imaging findings for various pathological conditions that cause deterioration in visual acuity.
    INT SCIENTIFIC INFORMATION INC, 2020年02月, Polich Journal of Radiology, 85, e67 - e81, 英語
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Kozuki R, Kono A, Tanaka C, Tahara J, Inukai J, Feibi Z, Nogami M, Yoneda K, Akashi K, Murakami T
    2020年02月, Japanese Archive of cases conference of clinical nuclear medicine, 2, 1 - 9
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Hamada MAS, Okada T, Yamaguchi M, Gotake Y, Okada K, Sugimoto K, Murakami T
    2020年02月, Interventional Radiology, 5(1) (1), 19 - 22, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Zech CJ, Ba-Ssalamah A, Berg T, Chandarana H, Chau GY, Grazioli L, Kim MJ, Lee JM, Merkle EM, Murakami T, Ricke J, B Sirlin C, Song B, Taouli B, Yoshimitsu K, Koh DM
    OBJECTIVES: The 8th International Forum for Liver Magnetic Resonance Imaging (MRI), held in Basel, Switzerland, in October 2017, brought together clinical and academic radiologists from around the world to discuss developments in and reach consensus on key issues in the field of gadoxetic acid-enhanced liver MRI since the previous Forum held in 2013. METHODS: Two main themes in liver MRI were considered in detail at the Forum: the use of gadoxetic acid for contrast-enhanced MRI in patients with liver cirrhosis and the technical performance of gadoxetic acid-enhanced liver MRI, both opportunities and challenges. This article summarises the expert presentations and the delegate voting on consensus statements discussed at the Forum. RESULTS AND CONCLUSIONS: It was concluded that gadoxetic acid-enhanced MRI has higher sensitivity for the diagnosis of hepatocellular carcinoma (HCC), when compared with multidetector CT, by utilising features of hyperenhancement in the arterial phase and hypointensity in the hepatobiliary phase (HBP). Recent HCC management guidelines recognise an increasing role for gadoxetic acid-enhanced MRI in early diagnosis and monitoring post-resection. Additional research is needed to define the role of HBP in predicting microvascular invasion, to better define washout during the transitional phase in gadoxetic acid-enhanced MRI for HCC diagnosis, and to reduce the artefacts encountered in the arterial phase. Technical developments are being directed to shortening the MRI protocol for reducing time and patient discomfort and toward utilising faster imaging and non-Cartesian free-breathing approaches that have the potential to improve multiphasic dynamic imaging. KEY POINTS: • Gadoxetic acid-enhanced MRI provides higher diagnostic sensitivity than CT for diagnosing HCC. • Gadoxetic acid-enhanced MRI has roles in early-HCC diagnosis and monitoring post-resection response. • Faster imaging and free-breathing approaches have potential to improve multiphasic dynamic imaging.
    2020年01月, European Radiology, 30(1) (1), 370 - 382, 英語, 国際誌
    [査読有り]

  • Ueshima E, Nishiofuku H, Takaki H, Hirata Y, Kodama H, Tanaka T, Kichikawa K, Yamakado K, Okada T, Sofue K, Yamaguchi M, Sugimoto K, Murakami T
    Introduction: The underlying mechanism involved in the recurrence of hepatoma after hepatic arterial embolization (HAE) is not adequately examined. An immunosuppressive cytokine, transforming growth factor β1 (TGF-β1), can lead to tumor progression and is affected by hypoxia in various cancers. The study aimed to assess the effect of HAE on the expression of TGF-β1 in a rat hepatoma model. Methods: Sprague-Dawley rats bearing N1S1 hepatoma cells underwent HAE (HAE group, n = 5) or sham treatment (sham group, n = 4). The animals were euthanized at 48 h, and liver tissues were harvested. Immunohistochemistry (IHC) and quantitative polymerase chain reaction (qPCR) were performed to compare the expression of TGF-β1 and hypoxia-inducible factor 1α (HIF-1α) between the HAE and sham groups. In vitro experiments with the N1S1 cell line were also performed under normoxic (21% O2) or hypoxic (1% O2) conditions for 48 h, and the expression of TGF-β1 and HIF-1α was assessed with western blotting and enzyme-linked immunosorbent assay. Statistical data comparisons were performed by Student t test. Results: IHC showed that both the TGF-β1-positive and HIF-1α-positive tumor peripheral areas were larger in the HAE group (6.59 ± 2.49 and 10.26 ± 4.14%; p < 0.001, respectively) than in the sham group (0.34 ± 0.41 and 0.40 ± 0.84% respectively). Similarly, qPCR showed that the mRNA expression levels of TGF-β1 and HIF-1α were higher (1.95 ± 0.38-fold and 1.62 ± 0.37-fold; p < 0.001 and p = 0.002, respectively) in the HAE group than those in the sham group. TGF-β1 expression was suppressed when HIF-1α inhibitors were added (p = 0.001), and HIF-1α expression was upregulated when exogenous TGF-β1 was added (p = 0.033) in N1S1 cells. Conclusion: HAE enhanced local TGF-β1 expression in a rat hepatoma model. In vitro experiments suggest that HAE-induced hypoxic stress may trigger the interdependent expression of TGF-β1 and HIF-1α.
    2020年01月, Liver cancer, 9(1) (1), 63 - 72, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Isaka Y, Hayashi H, Aonuma K, Horio M, Terada Y, Doi K, Fujigaki Y, Yasuda H, Sato T, Fujikura T, Kuwatsuru R, Toei H, Murakami R, Saito Y, Hirayama A, Murohara T, Sato A, Ishii H, Takayama T, Watanebe M, Awai K, Oda S, Murakami T, Yagyu Y, Joki N, Komatsu Y, Miyauchi T, Ito Y, Miyazawa R, Kanno Y, Ogawa T, Koshi E, Kosugi T, Yasuda Y
    2020年01月, Japanese journal of radiology, 38(1) (1), 3 - 46, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Maruyama K, Sofue K, Horinouchi H, Okada T, Ueshima E, Gentsu T, Sasaki K, Yamaguchi M, Sugimoto K, Murakami T
    OBJECTIVE: The aim of this study was to assess the utility of 70-kilovoltage-peak (kVp) contrast-enhanced computed tomography (CECT) for visualization and identification of the right adrenal vein (RAV) in comparison with that of conventional 120-kVp CECT. METHODS: This retrospective study included patients who underwent adrenal venous sampling with concurrent biphasic 120-kVp (120-kVp group, n = 43) or 70-kVp (70-kVp group, n = 47) CECT. Signal-to-noise ratios, contrast-to-noise ratios, longitudinal lengths, conspicuity scores, RAV detection rates, and size-specific dose estimates were compared between the 2 groups. RESULTS: In comparison with the 120-kVp group, the 70-kVp group had significantly higher signal-to-noise and contrast-to-noise ratios (P < 0.001-P = 0.033), greater longitudinal lengths (P < 0.001-P = 0.002), superior conspicuity scores for the RAV (P < 0.001), higher RAV detection rates (P = 0.015-P = 0.033), and lower size-specific dose estimates (P < 0.001). CONCLUSIONS: Seventy-kilovoltage-peak CECT has advantages over conventional 120-kVp CECT and is potentially useful for noninvasive assessment of the precise anatomy of the RAV.
    2020年01月, J Comput Assist Tomogr, 44(1) (1), 153 - 159
    [査読有り]
    研究論文（学術雑誌）

  • Kudo M, Izumi N, Kubo S, Kokudo N, Sakamoto M, Shiina S, Tateishi R, Nakashima O, Murakami T, Matsuyama Y, Takahashi A, Miyata H, Takayama T
    In the 20th Nationwide Follow-up Survey of Primary Liver Cancer in Japan, data from 21 075 new patients and 40 769 previously followed patients were compiled from 544 institutions over a 2-year period from 1 January 2008 to 31 December 2009. Compared with the previous 19th survey, the population of patients with hepatocellular carcinoma (HCC) was older at the time of clinical diagnosis, included more female patients, included more patients with non-B non-C HCC, had smaller tumor diameters and more frequently received radiofrequency ablation as local ablation therapy. Cumulative survival rates were calculated for HCC, intrahepatic cholangiocarcinoma, and combined hepatocellular cholangiocarcinoma (combined HCC and intrahepatic cholangiocarcinoma) by treatment type and by background characteristics for patients newly registered between 1998 and 2009 whose final outcome was survival or death. Cumulative survival rates for HCC were calculated by dividing patients by combinations of background factors (number of tumors, tumor diameter, and Child-Pugh grade) and by treatment types (hepatectomy, local ablation therapy, and transcatheter arterial chemoembolization). Cumulative survival rates and median overall survival in patients treated by resection, transcatheter arterial chemoembolization, and local ablation therapy were calculated. The same values were also calculated by the registration date by dividing patients newly registered between 1978 and 2009 into four time period groups . The results of the analysis show that the prognosis of HCC is improving dramatically. It is expected that the data obtained from this nationwide follow-up survey will contribute to advancing clinical research, including the design of clinical trials, as well as the treatment strategy of primary liver cancer in the clinical practice setting.
    2020年01月, Hepatology research : the official journal of the Japan Society of Hepatology, 50(1) (1), 15 - 46, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Aoki T, Kubota K, Hasegawa K, Kubo S, Izumi N, Kokudo N, Sakamoto M, Shiina S, Takayama T, Nakashima O, Matsuyama Y, Murakami T, Kudo M
    BACKGROUND: The impact of a wide surgical margin on the outcome of patients with hepatocellular carcinoma (HCC) has not been evaluated in relation to the type of liver resection performed, anatomical or non-anatomical. The aim of this study was to evaluate the impact of surgical margin status on outcomes in patients undergoing anatomical or non-anatomical resection for solitary HCC. METHODS: Data from patients with solitary HCC who had undergone non-anatomical partial resection (Hr0 group) or anatomical resection of one Couinaud segment (HrS group) between 2000 and 2007 were extracted from a nationwide survey database in Japan. Overall and recurrence-free survival associated with the surgical margin status and width were evaluated in the two groups. RESULTS: A total of 4457 patients were included in the Hr0 group and 3507 in the HrS group. A microscopically positive surgical margin was associated with poor overall survival in both groups. A negative but 0-mm surgical margin was associated with poorer overall and recurrence-free survival than a wider margin only in the Hr0 group. In the HrS group, the width of the surgical margin was not associated with patient outcome. CONCLUSION: Anatomical resection with a negative 0-mm surgical margin may be acceptable. Non-anatomical resection with a negative 0-mm margin was associated with a less favourable survival outcome.
    2020年01月, The British journal of surgery, 107(1) (1), 113 - 120, 英語, 国際誌
    [査読有り]

  • Isaki Y, Hayashi H, Aonuma K, Horio M, Terada Y, Doi K, Fujigaki Y, Yasuda H, Sato T, Fujikura T, Kuwatsuru R, Toei H, Murakami R, Saito Y, Hirayama A, Murohara T, Sato A, Ishii H, Takayama T, Watanabe M, Awai K, Oda S, Murakami T, Yagyu Y, Joki N, Komatsu Y, Miyauchi T, Ito Y, Miyazawa R, Kanno Y, Ogawa T, Koshi E, Kosugi T, Yasuda Y
    2019年11月, Circulation journal : official journal of the Japanese Circulation Society, 83(12) (12), 2572 - 2607, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Kokudo N, Takemura N, Hasegawa K, Takayama T, Kubo S, Shimada M, Nagano H, Hatano E, Izumi N, Kaneko S, Kudo M, Iijima H, Genda T, Tateishi R, Torimura T, Igaki H, Kobayashi S, Sakurai H, Murakami T, Watadani T, Matsuyama Y
    The fourth version of Clinical Practice Guidelines for Hepatocellular Carcinoma was revised by the Japan Society of Hepatology, according to the methodology of evidence-based medicine and partly to the Grading of Recommendations Assessment, Development, and Evaluation system, which was published in October 2017 in Japanese. New or revised recommendations were described, herein, with a special reference to the surveillance, diagnostic, and treatment algorithms.
    2019年10月, Hepatology Research, 49(10) (10), 1109 - 1113, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • 腎障害患者におけるヨード造影剤使用に関するガイドライン2018
    猪阪 善隆, 林 宏光, 青沼 和隆, 斎藤 能彦, 平山 篤志, 室原 豊明, 桑鶴 良平, 粟井 和夫, 村上 卓道, 菅野 義彦, 小松 康宏, 藤垣 嘉秀, 堀尾 勝, 佐藤 明, 高山 忠輝, 渡邉 真言, 石井 秀樹, 村上 隆介, 柳生 行伸, 藤榮 博史, 尾田 済太郎, 寺田 典生, 安田 日出夫, 常喜 信彦, 小川 智也, 林 宏樹, 藤倉 知行, 佐藤 太一, 土井 研人, 宮内 隆政, 伊藤 雄伍, 宮沢 亮, 古志 衣里, 小杉 智規, 安田 宜成, 興梠 征典, 鳴海 善文, 対馬 義人, 木村 剛, 玉木 長良, 島袋 朋子, 「腎障害患者におけるヨード造影剤使用に関するガイドライン」作成委員会, 日本腎臓学会, 日本医学放射線学会, 日本循環器学会
    (一社)日本腎臓学会, 2019年10月, 日本腎臓学会誌, 61(7) (7), 933 - 1081, 日本語

  • 全身PET/MRI撮像における高速化への試み BSREM再構成における指摘β値の検討
    野上 宗伸, 曽 菲比, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2019年10月, 核医学, 56(Suppl.) (Suppl.), S166 - S166, 英語
    [査読有り]

  • 当院における脾動脈瘤に対する動脈塞栓術の治療成績
    岡田 卓也, 佐々木 康二, Hamada Mostafa, 堀之内 宏樹, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本脈管学会, 2019年10月, 脈管学, 59(Suppl.) (Suppl.), S140 - S140, 日本語
    [査読有り]

  • Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績
    元津 倫幸, 山口 雅人, Hamada Mostafa, 佐々木 康二, 堀之内 宏樹, 上嶋 英介, 岡田 卓也, 祖父江 慶太郎, 後竹 康子, 中井 秀和, 山中 勝弘, 大村 篤史, 岡田 健次, 杉本 幸司, 村上 卓道
    (一社)日本脈管学会, 2019年10月, 脈管学, 59(Suppl.) (Suppl.), S175 - S175, 日本語
    [査読有り]

  • Kudo M, Ikeda M, Ueshima K, Sakamoto M, Shiina S, Tateishi R, Hasegawa K, Furuse J, Miyayama S, Murakami T, Yamashita T, Kokudo N
    Response Evaluation Criteria in Solid Tumors (RECIST) is inappropriate to assess the direct effects of treatment on hepatocellular carcinoma (HCC) by locoregional therapies, such as radiofrequency ablation and transarterial chemoembolization. Therefore, establishment of response evaluation criteria solely devoted to HCC is needed in clinical practice, as well as in clinical trials of HCC treatment, such as systemic therapies, which cause necrosis of the tumor. Response Evaluation Criteria in Cancer of the Liver (RECICL) was revised in 2019 by the Liver Cancer Study Group of Japan based on the 2015 version of RECICL, which was commonly used in Japan. The major revised points of the RECICL 2019 are as follows: (i) CEA and CA19-9 have been newly added as tumor markers that should be recorded for use as criteria in the response evaluation for intrahepatic cholangiocarcinoma; (ii) the criteria now state that the details of molecular targeted therapy should be specified; and (iii) specific methods for overall evaluation are now described. Also, as an assessment of overall TE4 requires that TE4 is achieved in all nodules (even non-target lesions), the same calculation methods described above are used. We hope this new treatment response criteria, RECICL, proposed by the Liver Cancer Study Group of Japan will benefit the HCC treatment response evaluation in the setting of daily clinical practice and clinical trials as well, not only in Japan, but also internationally.
    2019年09月, Hepatology Research, 49(9) (9), 981 - 989, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • 奇静脈弓経由でカテーテル塞栓術を施行し得た食道静脈瘤の1例
    岡崎 仁志, 伊崎 健太, 木下 知恵子, 酒井 英郎, 白川 裕, 尹 聖哲, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, 2019年09月, 日本医学放射線学会秋季臨床大会抄録集, 55回, S515 - S515, 日本語

  • 特発性孤立性SMA解離に対するステント留置直後に遠位閉塞をきたした1例
    木下 めぐ美, 川崎 竜太, 丸山 晃司, 清家 翔平, 野村 佳克, 長谷川 翔大, 辻本 貴紀, 松森 正術, 村上 博久, 田中 裕史, 向原 伸彦, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2019年09月, 日本インターベンショナルラジオロジー学会雑誌, 34(1) (1), 81 - 81, 日本語

  • 直腸静脈瘤に対して上直腸静脈直接穿刺法で塞栓術を行った1例
    元津 倫幸, 岡田 卓也, 小出 裕, 佐々木 康二, Hamada M.A.S., 堀之内 宏樹, 谷 龍一郎, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2019年09月, 日本インターベンショナルラジオロジー学会雑誌, 34(1) (1), 79 - 79, 日本語
    [査読有り]

  • Ueno Y, Takeuchi M, Tamada T, Sofue K, Takahashi S, Kamishima Y, Hinata N, Harada K, Fujisawa M, Murakami T
    A Vesical Imaging-Reporting and Data System (VI-RADS) based on multiparametric magnetic resonance imaging (mp-MRI) was developed to provide accurate information for the diagnosis of muscle-invasive bladder cancers (MIBCs). In this study we evaluated the interobserver agreement and diagnostic performance of VI-RADS. We retrospectively evaluated data for 74 consecutive patients with bladder cancer who had undergone mp-MRI before transurethral resection in a single institution from January 2010 to August 2018. Five readers assessed the probability of the presence of MIBC using VI-RADS scores. The interobserver agreement was assessed by measuring intraclass correlation coefficients (ICCs). Receiver operating characteristic (ROC) analysis was used to evaluate the MIBC diagnostic performance. The area under the ROC curve (AUC) was estimated for ordinal score assessments. Our study demonstrated that interobserver agreement was excellent among five readers (ICC 0.85, 95% confidence interval 0.80-0.89) and the diagnostic performance of VI-RADS was represented as a pooled AUC of 0.90 (95% confidence interval 0.87-0.93). PATIENT SUMMARY: We evaluated the interobserver agreement and diagnostic performance of a new scoring system based on magnetic resonance imaging called a Vesical Imaging-Reporting and Data System (VI-RADS) for muscle-invasive bladder cancer. Our results indicate that VI-RADS is suitable as a comprehensive tool for appropriate treatment planning for patients with bladder cancer.
    2019年07月, European urology, 76(1) (1), 54 - 56, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Maruyama K, Sofue K, Okada T, Koide Y, Ueshima E, Iguchi G, Tani R, Gentsu T, Horinouchi H, Sasaki K, Yamaguchi M, Sugimoto K, Murakami T
    PURPOSE: To evaluate the advantages of intraprocedural CT during adrenal venous sampling (AVS) to confirm accurate catheterization of the right adrenal vein (RAV). MATERIALS AND METHODS: This single-institution study included 106 patients (mean age 52.4 years; range 28-74 years) with primary aldosteronism who performed contrast-enhanced CT (CECT) before AVS following AVS between January 2011 and March 2018. After catheterization of the RAV under fluoroscopic guidance, unenhanced CT images were obtained to confirm catheter position on unified CT angiography system. Catheter repositioning was performed when the catheter was inaccurately positioned. Venography findings were classified into two groups: (1) presumably cannulated in the RAV (presumed RAV group) and (2) obscured visualization of the RAV because of collateral vessels (obscured RAV group). Success rates of AVS were compared using Fisher's exact test. RESULTS: The overall success of AVS was achieved in 104 patients (98.1%). Catheter was deviated into the IVC during intraprocedural CT in four patients. Fourteen patients (14.0%) required catheter repositioning by intraprocedural CT images, and accurate catheterization in the RAV was eventually accomplished. The success rate of AVS was significantly higher in the presumed RAV group (90.1% [73/81]) than that in the obscured RAV group (68.4% [13/19]) (p = 0.024). If intraprocedural CT was not acquired during AVS, the success rate of AVS would have been significantly lower (84.9% [90/106]) compared with that use of intraprocedural CT (98.1% [104/106]) (p < 0.001). CONCLUSIONS: Intraprocedural unenhanced CT by referring to the preprocedural CECT before AVS enables the confirmation of accurate catheterization of the RAV. LEVEL OF EVIDENCE: Level 4, case series.
    2019年04月, Cardiovascular and interventional radiology, 42(4) (4), 542 - 551, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Zeng F, Nogami M, Okunaga T, Kubo K, Murakami T
    2019年04月, Japanese Archive, Cases Conference of Clinical Nuclear Medicine (NMJ), 1, 13 - 16, 英語
    [査読有り]
    研究論文（大学，研究機関等紀要）

  • Tani R, Sofue K, Sugimoto K, Katayama N, Hamada Mostafa A.S, Maruyama K, Horinouchi H, Gentsu T, Ueshima E, Koide Y, Okada T, Yamaguchi M, Murakami T
    PURPOSE: To assess the safety and efficacy of transarterial embolization (TAE) and to evaluate the utility of contrast-enhanced computed tomography (CE-CT) for life-threatening spontaneous retroperitoneal hemorrhage (SRH). METHODS: Nineteen patients underwent TAE following CE-CT for life-threatening SRH. CE-CT and angiographic findings, technical successes, and clinical successes were evaluated. The diagnostic performance of CE-CT for the detection of active bleeding arteries was also assessed by two independent readers. RESULTS: Active extravasation of contrast material was accurately observed in 78.9‒84.2% of the patients on CE-CT. Angiograms revealed active extravasation in 37 arteries of 15 patients (78.9%), and 4 patients showed no sign of active bleeding. Sensitivity, positive predictive value, and accuracy rate of CE-CT for the detection of active bleeding vessels was 59.5%, 62.9‒71.0% and 55.6‒60.0% respectively. The successful embolization of 48 intended arteries was achieved in all the patients, including empirical TAE in four patients. Hemodynamic stabilization was achieved in 17 patients (89.5%) with a significant decrease in transfusion (p < 0.001). CONCLUSION: TAE is a technically safe and clinically effective treatment method for life-threatening SRH. CE-CT has moderate capability for accurate identification of active bleeding arteries. TAE including arteries that potentially distribute anatomic territory of the hematoma is essential.
    2019年04月, Japanese journal of radiology, 37(4) (4), 328 - 335, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Gentsu T, Okada T, Yamaguchi M, Horinouchi H, Katayama N, Ueshima E, Koide Y, Sofue K, Gotake Y, Nomura Y, Tanaka H, Okita Y, Sugimoto K, Murakami T
    PURPOSE: To evaluate the incidence of type II endoleak (EL-II) and aneurysm enlargement after endovascular aneurysm repair (EVAR) using the Endurant stent graft in patients with abdominal aortic aneurysm (AAA) with occluded inferior mesenteric artery (IMA). MATERIALS AND METHODS: Between 2012 and 2017, 103 patients who underwent EVAR using the Endurant stent graft for AAA with occluded IMA (50 patients with prophylactic embolized IMA and 53 with spontaneous occluded IMA) were retrospectively reviewed. The incidence of EL-II and aneurysm enlargement was evaluated. Predictive factors for persistent EL-II were evaluated based on patient characteristics, preprocedural anatomical characteristics, intraprocedural details, and postprocedural complications. RESULTS: Incidence rates of early EL-II and persistent EL-II were 6.8% (7/103 patients) and 4.9% (5/103 patients), respectively. Aneurysm enlargement was found in 10 patients (9.7%), including all 5 patients with persistent EL-II, 3 with de novo EL-II, and 2 with no EL-II. The rates of freedom from aneurysm enlargement at 1, 2, and 3 years were 98.7%, 97.0%, and 93.1% for the group without persistent EL-II, and 80.0%, 60.0%, and 20.0% for the group with persistent EL-II (p < 0.001), respectively. The maximum aneurysm diameter (odds ratio (OR), 1.16; 95% confidence interval (CI), 1.01-1.34; p = 0.0362) and the number of patent lumbar arteries (OR, 2.72; 95% CI, 1.07-6.90; p = 0.0357) were predictive of persistent EL-II. CONCLUSIONS: The incidence of EL-II after EVAR using the Endurant stent graft for AAA with occluded IMA was low, but most early EL-II persisted and resulted in aneurysm enlargement. Level of Evidence Level 4, Case Series.
    2019年04月, Cardiovascular and interventional radiology, 42(4) (4), 505 - 512, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 膵悪性リンパ腫の1例
    千葉 輝明, 高橋 一肇, 朝戸 信行, 松久保 祐子, 足利 竜一朗, 辻江 正徳, 村上 卓道
    (公社)日本医学放射線学会, 2019年02月, Japanese Journal of Radiology, 37(Suppl.) (Suppl.), 40 - 40, 日本語

  • 透析に合併したびまん性肺胞隔壁型アミロイドーシスの1例
    浜川 岳文, 松木 充, 鈴木 絢子, 土居 秀平, 沼本 勲男, 小田 晃義, 小塚 健倫, 村上 卓道
    (公社)日本医学放射線学会, 2019年02月, Japanese Journal of Radiology, 37(Suppl.) (Suppl.), 40 - 40, 日本語

  • Yamamuro M, Asai Y, Yamada K, Ozaki Y, Matsumoto M, Murakami T
    Springer Science and Business Media LLC, 2019年01月, Medical Biological Engineering Computing, 57(1) (1), 289 - 298
    [査読有り]
    研究論文（学術雑誌）

  • Keitaro Sofue, Masakatsu Tsurusaki, Takamichi Murakami
    Computed tomography (CT) has always played a major role in liver imaging. Recent advances in magnetic resonance imaging (MRI) and ultrasound, such as three-dimensional high-resolution sequences, parallel imaging techniques, and new contrast agents, have also increased the popularity and utilization of these imaging methods (Bryant et al. 2004 Lee et al. 2000). Nevertheless, development of multidetector-row CT technology has helped CT continue to excel in its already established indications, i.e., detection and characterization of hepatic lesions, and to add new clinical indications, i.e., CT angiography for pre-procedural mapping and liver perfusion (Sahani et al., AJR 179(1):53–59, 2002 Sahani et al., Comput Assist Tomogr 28(4):478–484, 2004 Guiney et al., Radiology 229(2):401–407, 2003 Schroeder et al., Radiology 224(2):586–591, 2002). The rapid pace of development of this technology has challenged radiologists in terms of the cost of replacement of scanners, optimization of CT protocols for existing indications, and development of protocols for the new applications made possible by multidetector-row CT technology. This paper discusses the advantages of multidetector-row CT for liver imaging, suggests guidelines to improve image quality through optimization of scanning protocols and strategies for administration of contrast, and reviews the potential clinical applications.
    Springer Verlag, 2019年, Medical Radiology, 447 - 489, 英語
    論文集(書籍)内論文

  • 曽 菲比, 野上 宗伸, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2019年, 核医学, 56(1) (1), 155 - 155, 日本語

  • 野上 宗伸, 曽 菲比, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2019年, 核医学, 56(1) (1), 155 - 155, 日本語

  • Sofue K, Itoh T, Takahashi S, Schmidt B, Shimada R, Negi N, Sugimura K, Murakami T
    2018年11月, Investigative Radiology, 53(11) (11), 673 - 680, 英語
    [査読有り][招待有り]
    研究論文（学術雑誌）

  • Motosugi U, Murakami T, Lee JM, Fowler KJ, Heiken JP, Sirlin CB, LI-RADS HBA Working Group
    2018年11月, J Magn Reson Imaging, 48(5) (5), 1169 - 1171
    [査読有り]

  • Sofue K, Tsurusaki M, Mileto A, Hyodo T, Sasaki K, Nishi T, Chikugo T, Yada N, Kudo M, Sugimura K, Murakami T
    AIM: To investigate whether iodine density measurements from contrast-enhanced dual-energy computed tomography (CT) data can non-invasively stage liver fibrosis. METHODS: This single-center, prospective study was approved by our IRB with written informed consent. Forty-seven consecutive patients (26 men and 21 women; mean age, 63.1 years) with chronic liver disease underwent contrast-enhanced dual-energy CT of the liver (non-contrast, arterial, portal venous, and equilibrium phase images), followed by liver biopsy. Iodine density of liver and aorta were obtained by two independent observers. Iodine uptake of the liver (Δ Liver), representing the difference in iodine density between equilibrium phase and non-contrast images, was calculated and normalized by aorta (Δ Liver/Aorta). We accounted for contrast agent distribution volume by using hematocrit level. Accuracy of iodine density measurements for staging liver fibrosis was assessed by using receiver operating characteristic (ROC) curves. Multivariate linear regression analysis was used to assess the impact of independent variables (liver fibrosis stage and patient-related confounders) on iodine uptake. RESULTS: The Δ Liver/Aorta significantly increased and moderately correlated with METAVIR liver fibrosis stage (ρ = 0.645, P < 0.001). Areas under the ROC curve ranged from 0.795 to 0.855 for discriminating each liver fibrosis score (≥F1-F4). METAVIR fibrosis stage was the most significant independent factor associated with Δ Liver (P = 0.005) and Δ Liver/Aorta (P < 0.001). CONCLUSION: Hepatic extracellular volume fraction with contrast-enhanced dual-energy CT can non-invasively stage liver fibrosis in chronic liver diseases. This technique could prove useful for monitoring disease progression and treatment response, potentially reducing the need for liver biopsy.
    2018年11月, Hepatology Research, 48(12) (12), 1008 - 1019, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Ueno YR, Tamada T, Takahashi S, Tanaka U, Sofue K, Kanda T, Nogami M, Ohno Y, Hinata N, Fujisawa M, Murakami T
    2018年09月, Korean J Radiol, 19(5) (5), 832 - 837, 英語
    [査読有り][招待有り]
    研究論文（学術雑誌）

  • Tsurusaki M, Oda T, Sofue K, Numoto I, Yagyu Y, Kashiwagi N, Murakami T
    British Institute of Radiology, 2018年09月, The British Journal of Radiology, 91(1092) (1092), ePub ahead of print - 20180124, 英語
    [査読有り][招待有り]
    研究論文（学術雑誌）

  • Kanda T, Wakabayashi Y, Zeng F, Ueno Y, Sofue K, Maeda T, Nogami M, Murakami T
    2018年09月, Jpn J Radiol, 36(9) (9), 519 - 527, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 縦隔発生の骨外性骨肉腫の一例
    岸田 雄治, 大野 良治, 関 紳一郎, 神保 直江, 伊藤 智雄, 田中 雄悟, 真庭 謙昌, 村上 卓道
    (公社)日本医学放射線学会, 2018年09月, 日本医学放射線学会秋季臨床大会抄録集, 54回, S523 - S523, 日本語
    [査読有り]

  • Hayato Kaida, Koichi Azuma, Akihiko Kawahara, Eiji Sadashima, Satoshi Hattori, Shinzo Takamori, Jun Akiba, Kiminori Fujimoto, Axel Rominger, Takamichi Murakami, Kazunari Ishii, Masatoshi Ishibashi
    Introduction: To assess the correlation among 18F-FDG uptake, Glut1, pStat1 and pStat3, and to investigate the relationship between the prognosis and 18F-FDG uptake and these molecular markers in surgically resected non-small cell lung cancer (NSCLC) patients. Results: Knockdown of Glut1 led to a significant increase in pStat1 expression. Glut1 expression positively correlated with the SUVmax, SUVmean, and TLG significantly (P<0.001). pStat3 expression negatively correlated with all PET parameters significantly (P<0.001). pStat1 had positive weak correlations with the SUVmax and SUVmean. All PET parameters and Glut1 were significantly associated with DFS (P<0.05). TLG, MTV, Glut1 and pStat1 were significantly associated with OS (P<0.05). Conclusion: pStat3 and Glut1 may be associated with 18F-FDG uptake mechanism. TLG, MTV, and Glut1 may be independent prognostic factors. Methods: The SUVmax, SUVmean, MTV and TLG of primary lesions were calculated in 140 patients. The expressions of Glut1 and Stat pathway proteins in NSCLC cell lines were examined by immune blots. Excised tumor tissue was analyzed by immunohistochemistry. OS and DFS were evaluated by the Kaplan-Meier method. The difference in survival between subgroups was analyzed by log-rank test. The prognostic significance of clinicopathological, molecular and PET parameters was assessed by Cox proportional hazard regression analysis.
    2018年08月, Oncotarget, 9(62) (62), 31971 - 31984, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Yuichi Wakabayashi, Ryuichi Takahashi, Tomonori Kanda, Feibi Zeng, Munenobu Nogami, Kazunari Ishii, Takamichi Murakami
    PURPOSE: We developed a new analytical method to quantify the dopamine transporter (DAT) radiation dose in the striatum on [123I] FP-CIT single-photon emission computed tomography (SPECT). This method is based on the dopamine transporter standardized uptake value (DaTSUV). The purpose of this study was to compare DaTSUV with the classical specific binding ratio (SBR) in the discrimination of dopaminergic neurodegenerative diseases (dNDD) from non-dNDD. METHOD: Seventy-seven consecutive patients who underwent DaTscan were included. Patients were divided into a dNDD group (n = 44; 24 men, 20 women; median age 73 years) and a non-dNDD group (n = 33; 14 men, 19 women; median age 75 years) based on their clinical diagnoses. The relationship between each method was evaluated by Pearson's correlation coefficient. Differences in SBR and DaTSUV in each group were evaluated by t test. Pairwise comparison of receiver operating characteristic (ROC) curve analysis was performed to compare the discriminating abilities of each method according to the standard error of the area under the curve (AUC). A value of p < 0.05 was considered statistically significant. RESULT: There was a significant strong correlation between DaTSUV and SBR (r = 0.910 [95% CI = 0.862-0.942], p < 0.001). The dNDD group showed significantly lower SBR (3.48 [1.25-7.91] vs 6.58 [3.81-11.1], p < 0.001) and DaTSUV (4.91 [1.59-13.6] vs 8.61 [2.29-15.6], p < 0.001) than the non-dNDD group. The discriminating ability of SBR (AUC = 0.918) was significantly higher than that of DaTSUV (AUC = 0.838, p = 0.0176). CONCLUSION: DaTSUV has a good correlation with SBR, but it could not exceed SBR for discriminating dNDD from non-dNDD.
    2018年08月, Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 39(8) (8), 1401 - 1407, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Nobuo Kashiwagi, Shin Ichi Nakatsuka, Takamichi Murakami, Eisuke Enoki, Kazuhiro Yamamoto, Katsuyuki Nakanishi, Takaaki Chikugo, Yoshitaka Kurisu, Masatomo Kimura, Tomoko Hyodo, Akio Tsukabe, Takahide Kakigi, Yasuhiko Tomita, Kazunari Ishii, Yoshifumi Narumi, Yukinobu Yagyu, Noriyuki Tomiyama
    OBJECTIVES: To report MR imaging features of mammary analogue secretory carcinoma (MASC) and acinic cell carcinoma (AciCC) of the salivary gland based on the latest version of the World Health Organization (WHO) 2017 classification of head and neck tumours. METHODS: MR images in 4 patients with MASC and 4 with AciCC were reviewed for margin characteristics, the presence of pathological cervical nodes, the presence of a cystic component and interface between cystic and solid component, signal intensity of the cystic components on T1 weighted images, and signal intensity of the solid component on T1 and T2 weighted images. RESULTS: All the MASCs and AciCCs had well-defined boundaries, and 1 AciCC had pathological nodes. All 4 MASCs presented as predominantly cystic tumours with papillary projection of the solid component. All 4 AciCCs presented as solid tumours. The signal intensity of the cystic components on T1 weighted images was entirely hyperintense in 2, and partly hyperintense demonstrating fluid-fluid level in 2. In all the MASCs, the signal intensity of the solid components on T1 weighted images was intermediate. In the AciCCs, the signal intensity of the solid components on T1 weighted images was high in 2 tumours and intermediate in 2. The signal intensity of the solid components on T2 weighted images varied from low to high in both MSACs and AciCCs. CONCLUSIONS: All 4 MASCs had a large cystic component, including areas of high signal intensity on T1 weighted images. The solid component appeared as a papillary projection into the cystic component. All 4 AciCCs presented as solid tumours, 2 of which showed high signal intensity on T1 weighted images.
    2018年07月, Dento maxillo facial radiology, 47(5) (5), 20170218 - 20170218, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Julia Sauerbeck, Kazunari Ishii, Chisa Hosokawa, Hayato Kaida, Franziska T Scheiwein, Kohei Hanaoka, Axel Rominger, Matthias Brendel, Peter Bartenstein, Takamichi Murakami
    PURPOSE: In subjects with amyloid deposition, striatal accumulation of 11C-Pittsburgh compound B (PiB) demonstrated by positron emission tomography (PET) is related to the stage of Alzheimer's disease (AD). In this study, we investigated the correlation between striatal and cortical non-displaceable binding potential (BPND). METHODS: Seventy-three subjects who complained of cognitive disturbance underwent dynamic PiB-PET studies and showed positive PiB accumulation were retrospectively selected. These subjects included 34 AD, 26 mild cognitive impairment, 2 frontotemporal lobar degeneration, 2 Parkinson's disease, 5 dementia with Lewy bodies, and 4 undefined diagnosis patients. Individual BPND images were produced from the dynamic data of the PiB-PET study, and voxel-based analyses were performed to estimate the correlations between striatal and other regional cortical BPND measures. RESULTS: There were highly significant correlations between striatal and prefrontal BPND, with the highest correlation being demonstrated in left Brodmann area 11. We found that almost all of the high cortical BPND values correlated with striatal BPND values, with the exception of the occipital cortex with low correlation. CONCLUSION: Our study demonstrated positive correlations in amyloid deposits between the striatum and other cortical areas with functional and anatomical links. The amyloid distribution in the brain is not random, but spreads following the functional and anatomical connections.
    2018年07月, Annals of nuclear medicine, 32(6) (6), 398 - 403, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Sofue K, Itoh T, Takahashi S, Schmidt B, Shimada R, Negi N, Sugimura K, Murakami T
    2018年06月, Investigative Radilogy, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Feibi Zeng, Munenobu Nogami, Taiichiro Shirai, Yoh Zen, Takamichi Murakami
    Iron overload is a major complication in blood transfusion procedures. This report presents a case of malignant lymphoma, in which the findings of bone marrow involvement were discordant between 18F-FDG PET imaging studies and MRI with diffusion-weighted imaging studies. In this case, the PET imaging studies were positive for malignant lymphoma, whereas the MRI studies were negative. Iron deposition in the reticuloendothelial system due to posttransfusion iron overload was considered to be the cause of the decrease in signal intensity on diffusion-weighted imaging, resulting in a false-negative finding on MRI.
    Lippincott Williams and Wilkins, 2018年05月, Clinical Nuclear Medicine, 43(5) (5), 361 - 362, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yasunori Minami, Tomohiro Minami, Satoru Hagiwara, Hiroshi Ida, Kazuomi Ueshima, Naoshi Nishida, Takamichi Murakami, Masatoshi Kudo
    Objectives: To assess the clinical feasibility of US-US image overlay fusion with evaluation of the ablative margin in radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). Methods: Fifty-three patients with 68 HCCs measuring 0.9–4.0 cm who underwent RFA guided by US-US overlay image fusion were included in this retrospective study. By an overlay of pre-/postoperative US, the tumor image could be projected onto the ablative hyperechoic zone. Therefore, the ablative margin three-dimensionally could be shown during the RFA procedure. US-US image overlay was compared to dynamic CT a few days after RFA for assessment of early treatment response. Accuracy of graded response was calculated, and the performance of US-US image overlay fusion was compared with that of CT using a Kappa agreement test. Results: Technically effective ablation was achieved in a single session, and 59 HCCs (86.8 %) succeeded in obtaining a 5-mm margin on CT. The response with US-US image overlay correctly predicted early CT evaluation with an accuracy of 92.6 % (63/68) (k = 0.67 95 % CI: 0.39–0.95). Conclusion: US-US image overlay fusion can be proposed as a feasible guidance in RFA with a safety margin and predicts early response of treatment assessment with high accuracy. Key points: • US-US image overlay fusion visualizes the ablative margin during RFA procedure. • Visualizing the margin during the procedure can prompt immediate complementary treatment. • US image fusion correlates with the results of early evaluation CT.
    Springer Verlag, 2018年05月, European Radiology, 28(5) (5), 1986 - 1993, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hayato Kaida, Koichi Azuma, Uhi Toh, Akihiko Kawahara, Eiji Sadashima, Satoshi Hattori, Jun Akiba, Nobuhiro Tahara, Axel Rominger, Kazunari Ishii, Takamichi Murakami, Masatoshi Ishibashi
    Objective: To assess the correlations between dual-phase uorine-18 uorodeoxyglucose (18F-FDG) uptake and clinicopathological and immunohistochemical prognostic factors in patients with surgically resected breast cancer stage I-III. Subjects and Methods: We retrospectively analyzed the cases of 105 patients. We calculated the maximum standardized uptake value (SUVmax) at 85min (SUV1), SUVmax at 125min (SUV2) and the retention index [RI]. Spearman's rank correlation test, the Kruskal-Wallis test and receiver operating characteristic (ROC) analysis were performed to assess the association between 18F-FDG uptake and the clinicopathological and immunohistochemical factors: glucose transporter-1 (Glut-1), estrogen receptor alpha (ERα), ERβ, progesterone receptor (PR), human epidermal growth factor 2 (Her2), mammalian target of rapamycin (mTOR), and P70S6kinase (P70S6). Results: The SUV1 and SUV2 values were correlated with Glut-1, pathological tumor size, ERα negativity, and pathological stage (all P values were < 0.05), but not with mTOR, P70S6, ERβ, PR, Her2 or other factors. The SUV1 and SUV2 in the triple negative subtype were signi-cantly higher than those of the hormone receptor-positive subtype (P< 0.05). The RI was associated with pathological tumor size alone. In the ROC analysis of Glut-1, the areas under the curve for SUV1 and SUV2 were signicantly larger than for RI (SUV1, P=0.032, SUV2, P=0.022). Conclusion: Glucose transporter-1, estrogen receptor alpha negativity and nuclear grade might affect the high 18F-FDG uptake in breast cancer. The SUVmax might be more useful than the RI for predicting the Glut-1 expression and the aggressiveness of breast cancer.
    P.Ziti and Co, 2018年01月, Hellenic Journal of Nuclear Medicine, 21(1) (1), 35 - 42, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Kaida H, Ishii K, Hanada S, Tohda Y, Murakami T
    A 78-year-old man had fever, persistent wheezing, and serum C-reactive protein elevation. Malignant lymphoma was suspected because of mediastinal lymph nodes swelling on CT and soluble interleukin 2 receptor elevation. Symmetric F-18-FDG uptake in the tracheobronchial tree and bilateral auricles was observed on PET/CT. He was finally diagnosed as having relapsing polychondritis by auricular cartilage biopsy. F-18-FDG PET/CT may have crucial role in evaluating the extent of inflammation and deciding the biopsy site of relapsing polychondritis.
    LIPPINCOTT WILLIAMS & WILKINS, 2018年01月, Clinical Nuclear Medicine, 43(1) (1), 25 - 27, 英語
    [査読有り]

  • Volumetric parameterを用いた食道癌切除患者の予後因子の検討
    甲斐田 勇人, 石井 一成, 細川 知紗, 柳生 行伸, 任 誠雲, 兵頭 朋子, 山田 穣, 細野 眞, 安田 卓司, 村上 卓道
    (一社)日本核医学会, 2017年09月, 核医学, 54(Suppl.) (Suppl.), S193 - S193, 日本語

  • Fukui H, Kashiwagi N, Murakami T, Watanabe Y, Hyodo T, Ishii K, Yamakawa M, Takahashi H, Tomiyama N
    The infraorbital canal (IOC), which runs in the roof of the maxillary sinus, is a useful anatomical landmark for the infraorbital nerve (ION) on computed tomography (CT) images. Enlargement of the IOC on CT images is thought to be a pathological state that usually affects the ION. However, we have frequently observed enlargement of the IOC in patients with a history of radical surgery of the maxillary sinus: so-called Caldwell-Luc (CL) surgery. In this study, the size of the IOC of the maxillary sinus was compared between patients with a history of CL surgery (post-CL IOCs) and those with no history of CL surgery (control IOCs). A total of 347 consecutive patients who underwent facial CT from January 2014 to October 2014 for various indications were evaluated. After excluding groove-type IOCs and IOCs with pathological lesions that could affect their diameters, 47 post-CL IOCs in 26 patients were finally compared with 504 control IOCs in 252 patients. To evaluate IOC size, the short-axis diameter of the IOC was measured on a reconstructed coronal image at the level of the posterior pole of the eyeball. The short-axis diameters of the post-CL IOCs and control IOCs were 3.0 +/- 0.6 and 1.4 +/- 0.3 mm, respectively (p < 0.005). The short-axis diameters of post-CL IOCs are significantly enlarged (approximately double the diameter) compared to those of control IOCs.
    SPRINGER, 2017年09月, Jpn J Radiol, 35(9) (9), 532 - 538, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hasegawa H, Ashikaga R, Okajima K, Wakayama T, Miyoshi M, Nishimura Y, Murakami T
    Purpose This study aimed to compare the detectability of neoplastic lesion enhancement after gadolinium-based contrast media injection in three-dimensional T1-weighted black blood Cube (3D-T1W BB Cube) and three-dimensional T1-weighted fast spoiled gradient-echo (3D-T1W fast SPGR) images obtained with 1.5-T magnetic resonance imaging (MRI). Materials and methods Phantom and clinical studies were performed to compare the lesion detectability and contrast ratio (CR) between 3D-T1W BB Cube and 3D-T1W fast SPGR pulse sequences. Results In the phantom study, the CRs for 3D-T1W BB Cube and 3D-T1W fast SPGR were equivalent at low gadolinium concentrations (0.125-1.25 mmol/l). In the clinical study, the detectability in the two modalities was similar for enhanced lesions >= 5 mm, but was significantly better in 3D-T1W BB Cube for lesions <5 mm (p = 0.011). Similarly, the CRs in both modalities were similar for lesions >= 5 mm (0.66 +/- 0.36 vs. 0.56 +/- 0.30, p = 0.153), but significantly lower in 3D-T1W BB Cube images for lesions <5 mm ( 0.29 +/- 0.19 vs. 0.39 +/- 0.21, p = 0.006). Conclusions Contrast 3D-T1W BB Cube imaging appears more sensitive than 3D-T1W fast SPGR imaging for detecting neoplastic lesion enhancement in the clinical setting using a 1.5-T MRI scanner, particularly for lesions <5 mm in diameter.
    SPRINGER, 2017年08月, Jpa J Radiol, 35(8) (8), 463 - 471, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Shimomura K, Araki F, Kono Y, Asai Y, Murakami T, Hyodo T, Okamura M, Matsumoto K, Monzen H, Nishimura Y
    The purpose of this study was to obtain the fraction by weight of the elemental composition and mass density of a humanoid tissue phantom that includes lung tissue, soft tissue, and bone tissue, by using dual energy computed tomography (DECT). The fraction by weight and the mass density for tissue-equivalent materials were calculated by means of a least-squares method with a linear attenuation coefficient, using monochromatic photon energies of 10-140keV, as obtained from DECT. The accuracy of calculated values for the fractions by weight of H (hydrogen), C (carbon), N (nitrogen), and O (oxygen) as verified by comparing the values with those that were analyzed using the combustion technique. The fraction by weight for other elements was confirmed by comparing with the analyzed values by means of energy dispersive photon spectroscopy. The calculated mass densities for each tissue were compared with those that were obtained by dividing the weight by volume. The calculated values of the fraction by weight that were obtained by means of DECT had differences of 1.9%, 9.2%, 6.6%, 7.8%, 0.8%, and 0.2% at a maximum for H, C, N, O, P (phosphorus), and Ca (calcium), respectively, from the reference values analyzed by the combustion technique and energy dispersive photon spectroscopy. The difference in the mass density for tissue was 0.011g/cm3 at a maximum. This study demonstrated the fraction by weight and the mass density of the humanoid tissue-equivalent materials that were calculated by means of DECT were expected high accuracy.
    2017年07月, Phys Med, 39, 59 - 66, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Masafumi Toguchi, Masakatsu Tsurusaki, Norihisa Yada, Keitaro Sofue, Tomoko Hyodo, Minori Onoda, Isao Numoto, Mitsuru Matsuki, Izumi Imaoka, Masatoshi Kudo, Takamichi Murakami
    Purpose: To evaluate the quantitative measurement of liver stiffness (LS), compare the diagnostic performance of magnetic resonance elastography (MRE) and ultrasound-based transient elastography (TE), and evaluate two different MRE-based LS measurement methods. Methods: Between October 2013 and January 2015, 116 consecutive patients with chronic liver disease underwent MRE to measure LS (kilopascals; kPa). Of the 116 patients, 51 patients underwent both TE and liver biopsy, and the interval between the liver biopsy and both the MRE and TE was less than 90 days. MRE-derived LS values were measured on the anterior segment of the right lobe (single small round regions of interest per slice; srROIs) and whole right lobe of the liver (free hand region of interest; fhROI), and these values were correlated with pathological fibrosis grades and diagnostic performance. Results: Pathological fibrosis stage was significantly correlated with srROIs (r = 0.87, p < 0.001), fhROI (r = 0.80, p < 0.001), and TE (r = 0.73, p < 0.001). For detection of significant fibrosis (>= F2), advanced fibrosis (>= F3), and cirrhosis, the area under the curve (AUC) associated with the srROIs was largest, and there was a significant difference between srROIs and TE (0.93 vs. 0.82, p = 0.006), srROIs and fhROI (0.93 vs. 0.89, p = 0.04) for detection of >= F2. For advanced fibrosis and cirrhosis detection, AUCs were not significant (0.92-0.96). Conclusions: MRE and TE detected liver fibrosis with comparable accuracy. In particular, the srROIs method was effective for detecting of significant fibrosis.
    SPRINGER, 2017年06月, ABDOMINAL RADIOLOGY, 42(6) (6), 1659 - 1666, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Wakabayashi Y, Ishii K, Hosokawa C, Hyodo T, Kaida H, Yamada M, Yagyu Y, Tsurusaki M, Kozuka T, Sugimura K, Murakami T
    2017年05月, Kobe J Med Sci, 62(5) (5), E136 - E141
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Nobuyuki Asato, Masakatsu Tsurusaki, Keitaro Sofue, Yoko Hieda, Takashi Katsube, Kazuhiro Kitajima, Takamichi Murakami
    Purpose To evaluate the diagnostic efficacy of gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) vs. contrast-enhanced computed tomography (CE-CT) in the detection of liver metastasis in colorectal carcinoma patients. Materials and methods One-hundred fifty-eight consecutive patients with histopathologically confirmed colorectal carcinoma underwent EOB-MRI and CE-CT; 68 patients had 105 surgically confirmed liver metastases. Diagnostic analyses were performed according to sensitivity and positive predictive value (PPV) for liver metastasis detection in combined arterial- and hepatocyte-phase images vs. CE-CT by three readers blinded to clinical data. Diagnostic accuracy and sensitivity were evaluated using the alternative free-response receiver operating characteristic method. Results The overall sensitivity of EOB-MRI (91.4%) was significantly higher than that of CE-CT (80.9%, p < 0.001); the higher sensitivity of EOB-MRI was observed especially in smaller-sized lesions (73.3 vs. 56.0% for lesions <= 1 cm; 91.9 vs. 80.8% for lesions > 1 cm and <= 2 cm; 99.2 vs. 95.7% for lesions > 2 cm). EOB-MRI showed a significantly greater area under the receiver operating characteristic curve (Az value = 0.970) compared with CE-CT (Az value = 0.899, p < 0.01). Conclusion EOB-MRI provided higher detectability for liver metastases, especially for smaller-sized lesions, than CE-CT in patients with colorectal carcinoma.
    SPRINGER, 2017年04月, JAPANESE JOURNAL OF RADIOLOGY, 35(4) (4), 197 - 205, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tomoko Hyodo, Norihisa Yada, Masatoshi Hori, Osamu Maenishi, Peter Lamb, Kosuke Sasaki, Minori Onoda, Masatoshi Kudo, Teruhito Mochizuki, Takamichi Murakami
    Purpose: To assess the clinical accuracy and reproducibility of liver fat quantification with the multimaterial decomposition (MMD) algorithm, comparing the performance of MMD with that of magnetic resonance (MR) spectroscopy by using liver biopsy as the reference standard. Materials and Methods: This prospective study was approved by the institutional ethics committee, and patients provided written informed consent. Thirty-three patients suspected of having hepatic steatosis underwent non-contrast material-enhanced and triple-phase dynamic contrast-enhanced dual-energy computed tomography (CT) (80 and 140 kVp) and single-voxel proton MR spectroscopy within 30 days before liver biopsy. Percentage fat volume fraction (FVF) images were generated by using the MMD algorithm on dual-energy CT data to measure hepatic fat content. FVFs determined by using dual-energy CT and percentage fat fractions (FFs) determined by using MR spectroscopy were compared with histologic steatosis grade (0-3, as defined by the nonalcoholic fatty liver disease activity score system) by using Jonck-heere-Terpstra trend tests and were compared with each other by using Bland-Altman analysis. Real non-contrast-enhanced FVFs were compared with triple-phase contrast-enhanced FVFs to determine the reproducibility of MMD by using Bland-Altman analyses. Results: Both dual-energy CT FVF and MR spectroscopy FF increased with increasing histologic steatosis grade (trend test, P <.001 for each). The Bland-Altman plot of dual-energy CT FVF and MR spectroscopy FF revealed a proportional bias, as indicated by the significant positive slope of the line regressing the difference on the average (P < .001). The 95% limits of agreement for the differences between real non-contrast- enhanced and contrast-enhanced FVFs were not greater than about 2%. Conclusion: The MMD algorithm quantifying hepatic fat in dual-energy CT images is accurate and reproducible across imaging phases. (C) RSNA, 2017
    RADIOLOGICAL SOC NORTH AMERICA, 2017年04月, RADIOLOGY, 283(1) (1), 108 - 118, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yasunori Minami, Masahiro Takita, Masakatsu Tsurusaki, Yukinobu Yagyu, Kazuomi Ueshima, Takamichi Murakami, Masatoshi Kudo
    AimTo investigate whether plain cone-beam computed tomography (CT) immediately after conventional transcatheter arterial chemoembolization (c-TACE) can help to predict tumor response semiquantitatively in patients with hepatocellular carcinoma (HCC). MethodsAnalysis was carried out retrospectively on 262 targeted HCCs in 169 patients treated with c-TACE. Dynamic CT was performed at baseline and 1-4months after c-TACE. Receiver-operating characteristic curve analysis was undertaken to evaluate whether voxel values of cone-beam CT could predict a complete response and to identify the cut-off value. Final tumor response assessment and early prediction using the retention pattern of iodized oil, the cut-off value of the density, and the combination of the cut-off density value and retention pattern of iodized oil in HCCs on postprocedural cone-beam CT were compared. ResultsComplete response was obtained in 72.9% of lesions. According to the pattern of iodized oil uptake, the sensitivity, specificity, and accuracy for predicting complete response were 85.9%, 70.4%, and 81.7%, respectively by excellent uptake on cone-beam CT. The area under the curve was 0.86 with the optimal cut-off at a voxel value of 200.13. According to not only the density but also the homogeneity of iodized oil retention, the sensitivity, specificity, and accuracy values for predicting complete response were 86.4%, 95.8%, and 88.9%, respectively. The predictive accuracy was significantly better than that of the pattern of iodized oil retention only (P=0.019). ConclusionThe combination of density and visual estimate of homogeneity is superior to either alone in predicting tumor response of c-TACE in HCC patients.
    WILEY, 2017年03月, HEPATOLOGY RESEARCH, 47(3) (3), E113 - E119, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masafumi Toguchi, Masakatsu Tsurusaki, Isao Numoto, Syojiro Hidaka, Miho Yamakawa, Nobuyuki Asato, SungWoon Im, Yukinobu Yagyu, Mitsuru Matsuki, Yoshifumi Takeyama, Takamichi Murakami
    To evaluate the feasibility and safety of the Amplatzer vascular plug (AVP) for preoperative common hepatic embolization (CHA) before distal pancreatectomy with en bloc celiac axis resection (DP-CAR) to redistribute blood flow to the stomach and liver via the superior mesenteric artery (SMA). Four patients (3 males, 1 female; median age 69 years) with locally advanced pancreatic body cancer underwent preoperative CHA embolization with AVP. After embolization, SMA arteriography was performed to confirm the alteration of blood flow from the SMA to the proper hepatic artery. In three of four patients, technical successes were achieved with sufficient margin from the origin of gastroduodenal artery. In one patient, the margin was less than 5 mm, although surgery was successfully performed without any problem. Eventually, all patients underwent the DP-CAR without arterial reconstruction or liver ischemia. AVP application is feasible and safe as an embolic procedure for preoperative CHA embolization of DP-CAR.
    SPRINGER, 2017年03月, CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 40(3) (3), 445 - 449, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 捻転を呈した漿膜下子宮筋腫の2例
    浜川 岳文, 松木 充, 沼本 勲男, 小田 晃義, 福井 秀行, 兵頭 朋子, 任 誠雲, 柳生 行伸, 今岡 いずみ, 鶴崎 正勝, 石井 一成, 村上 卓道
    日本画像医学会, 2017年02月, Japanese Journal of Diagnostic Imaging, 35(1) (1), 96 - 96, 日本語

  • ANCA関連腎炎に合併した縦隔線維症の1例
    日高 正二朗, 小塚 健倫, 浜川 岳文, 福井 秀行, 渡口 真史, 山田 穣, 任 誠雲, 柏木 伸夫, 細川 知紗, 鶴崎 正勝, 今岡 いずみ, 松木 充, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, 2017年02月, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 48 - 48, 日本語

  • 膀胱子宮内膜症の経過を追った2例
    沼本 勲男, 今岡 いずみ, 若林 雄一, 藤谷 哲也, 山川 美穂, 兵頭 朋子, 甲斐田 勇人, 柳生 行伸, 熊野 正士, 鶴崎 正勝, 松木 充, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, 2017年02月, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 49 - 49, 日本語

  • 上顎洞術後変化としての眼窩下管拡大
    福井 秀行, 柏木 伸夫, 任 誠雲, 甲斐田 勇人, 柳生 行伸, 小塚 健倫, 細川 知紗, 熊野 正士, 鶴崎 正勝, 松木 充, 今岡 いずみ, 石井 一成, 細野 眞, 村上 卓道
    (公社)日本医学放射線学会, 2017年02月, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 54 - 54, 日本語

  • Tomoko Hyodo, Masatoshi Hori, Peter Lamb, Kosuke Sasaki, Tetsuya Wakayama, Yasutaka Chiba, Teruhito Mochizuki, Takamichi Murakami
    Purpose: To assess the ability of fast-kilovolt-peak switching dualenergy computed tomography (CT) by using the multimaterial decomposition (MMD) algorithm to quantify liver fat. Materials and Methods: Fifteen syringes that contained various proportions of swine liver obtained from an abattoir, lard in food products, and iron (saccharated ferric oxide) were prepared. Approval of this study by the animal care and use committee was not required. Solid cylindrical phantoms that consisted of a polyurethane epoxy resin 20 and 30 cm in diameter that held the syringes were scanned with dual-and single-energy 64-section multidetector CT. CT attenuation on single-energy CT images (in Hounsfield units) and MMD-derived fat volume fraction (FVF; dual-energy CT FVF) were obtained for each syringe, as were magnetic resonance (MR) spectroscopy measurements by using a 1.5-T imager (fat fraction [ FF] of MR spectroscopy). Reference values of FVF (FVF ref) were determined by using the Soxhlet method. Iron concentrations were determined by inductively coupled plasma optical emission spectroscopy and divided into three ranges (0 mg per 100 g, 48.1-55.9 mg per 100 g, and 92.6-103.0 mg per 100 g). Statistical analysis included Spearman rank correlation and analysis of covariance. Results: Both dual-energy CT FVF (rho = 0.97; P < .001) and CT attenuation on single-energy CT images (rho = 20.97; P < .001) correlated significantly with FVF ref for phantoms without iron. Phantom size had a significant effect on dual-energy CT FVF after controlling for FVF ref (P < .001). The regression slopes for CT attenuation on single-energy CT images in 20-and 30-cm-diameter phantoms differed significantly (P = .015). In sections with higher iron concentrations, the linear coefficients of dual-energy CT FVF decreased and those of MR spectroscopy FF increased (P < .001). Conclusion: Dual-energy CT FVF allows for direct quantification of fat content in units of volume percent. Dual-energy CT FVF was larger in 30-cm than in 20-cm phantoms, though the effect of object size on fat estimation was less than that of CT attenuation on single-energy CT images. In the presence of iron, dual-energy CT FVF led to underestimateion of FVFref to a lesser degree than FF of MR spectroscopy led to overestimation of FVFref. (C) RSNA, 2016
    RADIOLOGICAL SOC NORTH AMERICA, 2017年02月, RADIOLOGY, 282(2) (2), 381 - 389, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Nobuo Kashiwagi, Eisuke Enoki, Chisa Hosokawa, Kenta Sakaguchi, Takamichi Murakami
    LIPPINCOTT WILLIAMS & WILKINS, 2017年02月, CLINICAL NUCLEAR MEDICINE, 42(2) (2), 131 - 132, 英語
    [査読有り]

  • H. Takahashi, K. Ishii, N. Kashiwagi, Y. Watanabe, H. Tanaka, T. Murakami, N. Tomiyama
    AIM: To evaluate the performance of apparent diffusion coefficient (ADC) mapping compared with voxel-based morphometry and to demonstrate the clinical usefulness of ADC mapping in the diagnosis of Alzheimer's disease (AD). MATERIALS AND METHODS: The study population comprised 31 patients with AD (group A) and 24 patients without dementia (group B) who underwent three-dimensional (3D) T1weighted imaging (WI) and two- dimensional (2D) echo-planar diffusion-weighted imaging (DWI) at 3 T. The volume and ADC of the regional grey matter (GM) in the bilateral hippocampi, precunei, and the anterior and posterior cingulate gyri were calculated using a voxelbased method for automatic segmentation of brain structures. The significance of intergroup differences in each volume and ADC of all regional GM was tested using analysis of variance (ANOVA) with Bonferroni correction. Intergroup regional GM differences in each volume and ADC were evaluated using statistical parametric mapping (SPM). RESULTS: In group A, the volumes of the precunei (mean value: group A/B = 18.93/21.48 cm(3)) and the anterior cingulate gyri (mean value: group A/B = 6.1/7.81 cm(3)) were significantly less than in group B (p < 0.05). The ADC in group A was significantly larger than that in group B in the bilateral hippocampi (mean value: group A/B = right 1020.79x10(6)/ 877.23x10(-6) mm(2)/s; left 1072.89x10(-6)/900.2x10(-6) mm(2)/s) and posterior cingulate gyri (mean value: group A/B = 1006.77x10-(6)/876.88x10(-6) mm(2)/s; p < 0.05). SPM showed that the areas of increased ADC were more extensive than the areas of decreased volume in the bilateral hippocampi, precunei, and posterior cingulate gyri in group A, compared with those in group B (p < 0.001). CONCLUSION: Evaluation of ADC mapping can quantify changes in brain water diffusivity and may improve the performance of automatic morphometric diagnosis of AD. 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
    W B SAUNDERS CO LTD, 2017年02月, CLINICAL RADIOLOGY, 72(2) (2), 108 - 115, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yasuharu Imai, Kazuhiro Katayama, Masatoshi Hori, Takayuki Yakushijin, Kenji Fujimoto, Toshifumi Itoh, Takumi Igura, Mitsuru Sakakibara, Manabu Takamura, Masakatsu Tsurusaki, Hiroto Takahashi, Katsuyuki Nakanishi, Noriaki Usuki, Koh Tsuji, Hiroshi Ohashi, Tonsok Kim, Tetsuo Takehara, Takamichi Murakami
    Background: We prospectively compared the efficacy of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) with that of dynamic multidetector computed tomography (MDCT) for detection of recurrent hypervascular hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). Methods: Institutional review board approval and written informed consent were obtained for this multicenter study. Ninety-seven HCC patients treated with curative RFA underwent both Gd-EOB-DTPA-enhanced MRI and dynamic MDCT every 3-4 months. HCC diagnosis was made based on the typical enhancement pattern of HCC on MRI and/or CT by on-site consensus reading. Two blinded observers independently assessed image datasets to compare diagnostic accuracy, sensitivity, specificity, and the areas under the receiver operating characteristic curve (AUROC). Results: Recurrence was observed in 48 of 97 patients. Among these, 22 were diagnosed by both Gd-EOB-DTPA-enhanced MRI and MDCT; the remainder were diagnosed by only one of these 2 modalities. Recurrence was diagnosed in more patients by Gd-EOB-DTPA-enhanced MRI than by MDCT (44 vs. 26 patients, p < 0.001). Patient-based analysis revealed that the accuracy, sensitivity, and AUROC of Gd-EOB-DTPA-enhanced MRI were significantly higher than those of MDCT for both observers (p < 0.005). The AUROC of Gd-EOB-DTPA-enhanced MRI and MDCT was 0.95 and 0.76 for observer 1 and 0.90 and 0.74 for observer 2, respectively. The. values for MRI and MDCT were 0.83 and 0.70, respectively. Conclusions: Compared with dynamic MDCT, Gd-EOB-DTPA-enhanced MRI had higher diagnostic accuracy and sensitivity for detection of recurrent hypervascular HCC and may be a better tool for following patients after RFA. (C) 2017 S. Karger AG, Basel
    KARGER, 2017年, LIVER CANCER, 6(4) (4), 349 - 359, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Aerosol deposition of inhaled corticosteroids/long-acting Ɓ2-agonists in the peripheral airways of patients with asthma using functional respiratory imaging, a novel imaging technolog.
    Iwanaga T, Kozuka T, Nakanishi J, Yamada K, Nishiyama O, Sano H, Murakami T, Tohda Y
    2017年, Pulm Ther (in press)
    [査読有り]

  • Okada M, Murakami T, Kuwatsuru R, Nakamura Y, Isoda H, Goshima S, Hanaoka R, Haradome H, Shinagawa Y, Kitao A, Fujinaga Y, Marugami N, Yuki M, Ichikawa T, Higaki A, Hori M, Fujii S, Matsui O
    Purpose: To identify biochemical factors associated with liver enhancement over time on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) images and predict the optimal time point of the hepatobiliary phase in various clinical settings. Materials and Methods: This study was approved by the institutional review boards, and written informed consent was obtained from the 1903 patients enrolled. Simple and multiple logistic regression analyses were performed to investigate the biochemical factors associated with liver-to-spleen contrast (LSC) of at least 1.5 in the hepatobiliary phase. Changes in LSC and lesion-to-liver contrast (LLC) of lesions over time (at 5, 10, 15, and 20 minutes) were investigated with a linear mixed-effects model in patients and lesions. For LSC, the optimal cutoff value was determined with receiver operating characteristic analysis of the most significant variable. Differences in LSC and LLC were analyzed in various clinical settings. Results: Ultimately, 1870 patients were evaluated, as 33 were excluded according to study criteria. Prothrombin (PT) activity, total bilirubin level (P=.020), and total cholesterol level (P=.005) were significantly associated with LSC of at least 1.5 at 20 minutes, and PT activity was identified as the most significant factor (odds ratio, 1.271; 95% confidence interval: 1.109, 1.455; P=.001). LSC of at least 1.5 at 20 minutes with PT activity of at least 86.9% and less than 86.9% occurred in 555 of 626 patients (88.6%) and 388 of 575 patients (67.5%), respectively. Satisfactory liver enhancement at 20 minutes was significantly more likely to be achieved by patients with hepatitis B virus than by those with hepatitis C virus (P<.001) and by patients with metastasis than by those with hepatocellular carcinoma (P<.001). No significant difference in LLC was observed in patients examined at 1.5 and 3.0 T (P=.133). Conclusion: Hepatic enhancement is significantly associated with PT activity, total bilirubin level, and total cholesterol level. PT activity of at least 86.9% could be used to shorten examination times at Gd-EOB-DTPA-enhanced MR imaging. (C) RSNA, 2016
    RADIOLOGICAL SOC NORTH AMERICA, 2016年11月, Radiology, 281(2) (2), 474 - 483, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 経カテーテル動脈塞栓術を施行した腹部内臓動脈瘤の4例
    朝戸 信行, 高橋 一肇, 足利 竜一朗, 沼本 勲男, 柳生 行伸, 鶴崎 正勝, 村上 卓道
    (一社)日本脈管学会, 2016年10月, 脈管学, 56(Suppl.) (Suppl.), S212 - S213, 日本語

  • 薬剤動態に基づいたアミロイドイメージングに対する雑音低減アルゴリズム
    木村 裕一, 藤井 康介, 山田 誉大, 細川 知紗, 坂田 宗之, 石井 一成, 村上 卓道
    (一社)日本核医学会, 2016年10月, 核医学, 53(Suppl.) (Suppl.), S277 - S277, 日本語

  • 非小細胞肺癌のFDG集積とGlut-1、pStat-1、pStat-3での予後因子の検討
    甲斐田 勇人, 東 公一, 河原 明彦, 服部 聡, 倉田 精二, 高森 信三, 藤本 公則, 鹿毛 政義, 石井 一成, 村上 卓道, 石橋 正敏
    (一社)日本核医学会, 2016年10月, 核医学, 53(Suppl.) (Suppl.), S283 - S283, 日本語

  • Hayato Kaida, Koichi Azuma, Akihiko Kawahara, Masafumi Yasunaga, Yuhei Kitasato, Satoshi Hattori, Tomoki Taira, Hiroki Ureshino, Masayoshi Kage, Kazunari Ishii, Takamichi Murakami, Masatoshi Ishibashi
    Purpose: We examined whether fluorine-18 fluorodeoxyglucose (FDG) uptake is related to the mammalian target of rapamycin (mTOR) signal pathway and its related proteins in pancreatic cancer patients. Methods: We retrospectively studied 53 pancreatic cancer patients who underwent FDG positron emission tomography (PET) or FDG PET/CT, and complete curative surgical resection. The SUV max, the tumor to nontumor activity of pancreas [T/N (P)] ratio and the T/N of liver [T/N (L)] ratio were calculated. The expressions of glucose transporter-1( Glut-1) and mTOR pathway proteins in pancreas cell lines were examined by immune blots. Excised tumor tissue was analyzed by immunohistochemistry using monoclonal antibodies for Glut-1, epidermal growth factor receptor (EGFR), mTOR, p70S6kinase (p70S6) and S6 ribosomal protein (S6). Results: The expressions of Glut-1, EGFR and p70S6 were significantly correlated with the SUV max, T/N (P) ratio and T/N (L) ratio. The expressions of mTOR and S6 were not correlated with all parameters. The expression of Glut-1 was positively correlated with the expressions of EGFR and p70S6, but not with mTOR or S6. S6 was positively correlated with p70S6. Conclusions: Glut-1, EGFR and p70S6 expressions are associated with the FDG uptake mechanism of pancreatic cancer. FDG uptake may predict the levels of EGFR and p70S6 expressions, and FDG uptake reflects glucose metabolism and cancer progression. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
    ELSEVIER IRELAND LTD, 2016年10月, EUROPEAN JOURNAL OF RADIOLOGY, 85(10) (10), 1804 - 1810, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 松木 充, 浜川 岳文, 小田 晃義, 沼本 勲男, 福井 秀行, 任 誠雲, 柳生 行伸, 村上 卓道
    (株)学研メディカル秀潤社, 2016年09月, 画像診断, 36(12) (12), 1171 - 1183, 日本語

  • 逐次近似応用再構成法が超急性期脳梗塞CT画像におけるZスコアマッピングに与える影響
    渡邊 翔太, 坂口 健太, 細野 眞, 石井 一成, 村上 卓道, 市川 勝弘
    (公社)日本放射線技術学会, 2016年09月, 日本放射線技術学会雑誌, 72(9) (9), 813 - 813, 日本語

  • Masakatsu Tsurusaki, Keitaro Sofue, Takamichi Murakami
    A variety of imaging techniques, including ultrasonography (US), multidetector computed tomography (MDCT), magnetic resonance imaging (MRI) and positron emission tomography combined with CT scan (PET/CT), are available for diagnosis and treatment planning in liver metastasis. Contrast-enhanced MDCT is a relatively non-invasive, widely available and standardized method for hepatic work-up. Gadoxetic acid (gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid; EOB Primovist (R)]) is a recently developed liver-specific hepatobiliary MR contrast agent that offers both dynamic imaging as well as liver-specific static hepatocyte imaging, referred to as the hepatobiliary phase. Following contrast injection, this technique reveals dynamic vascular phases (arterial, portal venous and delayed phases), in addition to the hepatobiliary phase upon uptake by functional hepatocytes. The overall sensitivity of gadoxetic acid-enhanced MRI was significantly higher than that of contrast-enhanced CT. Specifically, the higher sensitivity of gadoxetic acid-enhanced MRI was observed in lesions smaller than 1cm in diameter. Gadoxetic acid-enhanced MRI is considered an extremely useful tool for the diagnosis of liver metastases. Future studies will focus on diagnostic algorithms involving combinations of modalities such as MRI, MDCT and/or F-18-fluorodeoxyglucose PET/CT, which may impact the treatment plan for these patients.
    WILEY, 2016年08月, HEPATOLOGY RESEARCH, 46(9) (9), 853 - 861, 英語
    [査読有り]

  • 仰臥位と腹臥位CTの重力差による動的評価とCT値による客観評価を用いた進行食道癌における新しい大動脈壁浸潤評価法
    田中 裕美子, 白石 治, 熊野 正士, 曽我部 俊介, 岩間 密, 安田 篤, 新海 政幸, 今野 元博, 今本 治彦, 村上 卓道, 奥野 清隆, 安田 卓司
    切除困難な局所進行食道癌cT4(大動脈)も化学療法(ChT)/化学放射線療法(CRT)の進歩に伴い治癒切除率が向上し、より精度の高い深達度診断が求められている。我々は通常の仰臥位CTでのcT4診断(Picus角(PA)≧90度)に加え、重力差を利用した腹臥位CTとの比較による動的評価法を考案し、その有用性を検討した。対象は初診時仰臥位造影CTでcT3以深の食道癌22例(cT3/T4=17/5)35測定、全例ChT/CRTを先行し18例で手術を施行。腫瘍-大動脈壁間距離(T-A D)とPAを仰/腹CTで測定し、最終深達度(fT4=R1、2、fT3.5=R0 and著明な瘢痕化(+)、fT3=R0 and瘢痕化(-)、非手術例はEUS所見)と比較した。全35測定の平均後縦隔前後径(下縦隔)は仰/腹の順に12.3/26.0mmで、PA<60度(21測定)の平均T-A DとPAは3.0/4.4mm、23.2/16度と腹臥位で距離は延長し角度は縮小した(p<0.05)。治療前PA≧60度の10例はfT3/T3.5/T4=5/2/3。fT3は腹臥位で全例PAは減少しT-A Dも3/5例で延長、fT3.5はいずれかが不変、fT4は両方不変であった。以上より、仰/腹CTにおけるT-A D/PAの比較はT3(両方変化)、T3.5(いずれか不変)、T4(両方不変)を鑑別できる可能性が示唆された。(著者抄録)
    近畿大学医学会, 2016年06月, 近畿大学医学雑誌, 41(1-2) (1-2), 27 - 38, 日本語

  • Masafumi Toguchi, Mitsuru Matsuki, Isao Numoto, Masakatsu Tsurusaki, Izumi Imaoka, Kazunari Ishii, Rikiya Yamashita, Yuki Inada, Shuichi Monzawa, Hisato Kobayashi, Takamichi Murakami
    There are three types of breast cancer recurrence which can occur after initial treatment: local, regional, and distant. Distant metastases are more frequent than local and regional recurrences. It usually occurs several years after the primary breast cancer, although it is sometimes diagnosed at the same time as the primary breast cancer. Although the common distant metastases are bone, lung and liver, breast cancer has the potential to metastasize to almost any region of the body. Early detection and treatment of distant metastases improves the prognosis, therefore radiologists and clinicians should recognize the possibility of metastasis from breast cancer and grasp the imaging characteristics. In this report, we demonstrate the imaging characteristics of metastases from breast cancer to uncommon sites.
    SPRINGER, 2016年06月, JAPANESE JOURNAL OF RADIOLOGY, 34(6) (6), 400 - 408, 英語
    [査読有り]

  • 仰臥位と腹臥位CTにおける重力差とCT値による客観評価を用いた新しい進行食道癌大動脈浸潤の評価の有用性
    田中 裕美子, 白石 治, 熊野 正士, 曽我部 俊介, 岩間 密, 安田 篤, 新海 政幸, 今野 元博, 今本 治彦, 村上 卓道, 安田 卓司
    (一社)日本外科学会, 2016年04月, 日本外科学会定期学術集会抄録集, 116回, OP - 2, 日本語

  • Takeshi Miyata, Masayuki Kitano, Shunsuke Omoto, Kumpei Kadosaka, Ken Kamata, Hajime Imai, Hiroki Sakamoto, Naoshi Nisida, Yogesh Harwani, Takamichi Murakami, Yoshifumi Takeyama, Yasutaka Chiba, Masatoshi Kudo
    AIM: To assess the usefulness of contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) for lymph node metastasis in pancreatobiliary carcinoma. METHODS: All patients suspected of pancreatobiliary carcinoma with visible lymph nodes after standard EUS between June, 2009 and January, 2012 were enrolled. In the primary analysis, patients with successful EUS-fine needle aspiration (FNA) were included. The lymph nodes were assessed by several standard EUS variables (short and long axis lengths, shape, edge characteristic and echogenicity), color Doppler EUS variable [central intranodal blood vessel (CIV) presence] and CH-EUS variable (heterogeneous/homogeneous enhancement patterns). The diagnostic accuracy relative to EUS-FNA was calculated. In the second analysis, N-stage diagnostic accuracy of CH-EUS was compared with EUS-FNA in patients who underwent surgical resection. RESULTS: One hundred and nine patients (143 lymph nodes) fulfilled the criteria. The short axis cutoff >= 13 mm predicted malignancy with a sensitivity and specificity of 72% and 85%, respectively. These values were 72% and 63% for the long axis cut-off >= 20 mm, 62% and 75% for the round shape variable, 81% and 30% for the sharp edge variable, 66% and 61% for the hypoechogenicity variable, 70% and 72% for the CIV-absent variable, and 83% and 91% for the heterogeneous CH-EUS-enhancement variable, respectively. CH-EUS was more accurate than standard and color Doppler EUS, except the short axis cut-off. Notably, three patients excluded because of EUS-FNA failure were correctly N-staged by CH-EUS. CONCLUSION: CH-EUS complements standard and color Doppler EUS and EUS-FNA for assessment of lymph node metastases.
    BAISHIDENG PUBLISHING GROUP INC, 2016年03月, WORLD JOURNAL OF GASTROENTEROLOGY, 22(12) (12), 3381 - 3391, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • 上顎洞術後変化としての眼窩下管拡大
    福井 秀行, 柏木 伸夫, 任 誠雲, 甲斐田 勇人, 柳生 行伸, 小塚 健倫, 細川 知紗, 熊野 正士, 鶴崎 正勝, 松木 充, 今岡 いずみ, 細野 眞, 石井 一成, 村上 卓道
    日本画像医学会, 2016年02月, Japanese Journal of Diagnostic Imaging, 34(1) (1), 116 - 116, 日本語

  • IgG4関連疾患によると思われる冠動脈病変の1例
    千葉 輝明, 松木 充, 今岡 いずみ, 熊野 正士, 小塚 健倫, 柏木 伸夫, 柳生 行伸, 足利 竜一朗, 鶴崎 正勝, 石井 一成, 村上 卓道, 平野 豊, 樋野 尚一
    (公社)日本医学放射線学会, 2016年02月, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 55 - 55, 日本語

  • 当院における胃粘膜下腫瘍に対する18F-FDG PET検査
    沼本 勲男, 松木 充, 福井 秀行, 若林 雄一, 渡口 真史, 千葉 輝明, 山田 穣, 柏木 伸夫, 細川 知紗, 小塚 健倫, 細野 眞, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, 2016年02月, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 56 - 56, 日本語

  • Yoshito Tsushima, Tsuneo Ishiguchi, Takamichi Murakami, Hiromitsu Hayashi, Katsumi Hayakawa, Kunihiko Fukuda, Yukunori Korogi, Hideharu Sugimoto, Yasuo Takehara, Yoshifumi Narumi, Yasuaki Arai, Ryohei Kuwatsuru, Kengo Yoshimitsu, Kazuo Awai, Masayuki Kanematsu, Ryo Takagi
    To help establish consensus on the safe use of contrast media in Japan. Questionnaires were sent to accredited teaching hospitals with radiology residency programs. The reply rate was 45.4 % (329/724). For contrast-induced nephropathy (CIN), chronic and acute kidney diseases were considered a risk factor in 96.7 and 93.6 %, respectively, and dehydration in 73.9 %. As preventive actions, intravenous hydration (89.1 %) and reduction of iodinated contrast media dose (86.9 %) were commonly performed. For nephrogenic systemic fibrosis (NSF), chronic and acute kidney diseases were considered risk factors in 98.5 and 90.6 %, respectively, but use of unstable gadolinium-based contrast media was considered a risk factor in only 55.6 %. A renal function test was always (63.5 % in iodinated; 65.7 % in gadolinium) or almost always (23.1; 19.8 %) performed, and estimated glomerular filtration rate (eGFR) was the parameter most frequently used (80.8; 82.6 %). For the patients with risk factors for acute adverse reaction (AAR), steroid premedication or/and change of contrast medium were frequent preventive actions, but intravenous steroid administration immediately before contrast media use was still performed. Our questionnaire survey revealed that preventive actions against CIN were properly performed based on patientsE1/4 eGFR. Preventive actions against NSF and AAR still lacked consensus.
    SPRINGER, 2016年02月, JAPANESE JOURNAL OF RADIOLOGY, 34(2) (2), 130 - 139, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tatsuo Inoue, Tomoko Hyodo, Keiko Korenaga, Takamichi Murakami, Yasuharu Imai, Atsushi Higaki, Takeshi Suda, Toru Takano, Kennichi Miyoshi, Masahiko Koda, Hironori Tanaka, Hiroko Iijima, Hironori Ochi, Masashi Hirooka, Kazushi Numata, Masatoshi Kudo
    Background It remains unknown whether Kupffer-phase images in Sonazoid-enhanced ultrasonography (US) can be used to predict hypervascularization of borderline lesions. Therefore, we aimed to clarify whether Kupffer-phase images in Sonazoid-enhanced ultrasonography can predict subsequent hypervascularization in hypovascular borderline lesions detected on hepatobiliary-phase gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (GdEOB-DTPA)-enhanced magnetic resonance imaging. Methods From January 2008 to March 2012, 616 low-intensity hypovascular nodules were detected in hepatobiliary-phase images of Gd-EOB-DTPA-enhanced MRI at nine institutions. Among these, 167 nodules, which were confirmed as hypovascular by Gd-EOB-DTPA-enhanced MRI and Sonazoid-enhanced US, were evaluated in this study. Potential hypervascularization factors were selected based on their clinical significance and the results of previous reports. The Kaplan-Meier model and log-rank test were used for univariate analysis and the Cox regression model was used for multivariate analysis. Results The cumulative incidence of hypervascularization of borderline lesions was 18, 37, and 43 % at 1, 2, and 3 years, respectively. Univariate analyses showed that tumor size (p = 0.0012) and hypoperfusion on Kupffer-phase images in Sonazoid-enhanced US (p = 0.004) were associated with hypervascularization of the tumor. Multivariate analysis showed that tumor size [HR: 1.086, 95 % confidence interval = 1.027-1.148, p = 0.004] and hypo perfusion on Kupffer-phase images [HR: 3.684, 95 % confidence interval = 1.798-7.546, p = 0.0004] were significantly different. Conclusions Kupffer-phase images in Sonazoid-enhanced US and tumor diameter can predict hypervascularization of hypointense borderline lesions detected on hepatobiliary-phase Gd-EOB-DTPA-enhanced MRI.
    SPRINGER JAPAN KK, 2016年02月, JOURNAL OF GASTROENTEROLOGY, 51(2) (2), 144 - 152, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masatoshi Kudo, Kazuomi Ueshima, Shoji Kubo, Michiie Sakamoto, Masatoshi Tanaka, Iwao Ikai, Junji Furuse, Takamichi Murakami, Masumi Kadoya, Norihiro Kokudo
    The Response Evaluation Criteria in Solid Tumors (RECIST) is inappropriate to assess the direct effects of treatment on hepatocellular carcinoma (HCC) by locoregional therapies such as radiofrequency ablation (RFA) and transarterial chemoembolization (TACE). Therefore, establishment of response evaluation criteria solely devoted to HCC is needed urgently in clinical practice as well as in clinical trials of HCC treatment, such as molecular-targeted therapies, which cause necrosis of the tumor. The Response Evaluation Criteria in Cancer of the Liver (RECICL) was revised in 2015 by the Liver Cancer Study Group of Japan based on the 2009 version of RECICL, which was commonly used in Japan. Major revised points of the RECICL 2015 is to define the target lesions of two lesions per organ or three lesions per liver, up to a maximum of five lesions. The second revised point is that setting the timing at which the overall treatment response has been changed. The third point is that the definition of treatment effect 1 has been changed to more than 50% tumor enlargement, excluding the area of necrosis after treatment. Overall evaluation of treatment response has been amended to make it possible to evaluate the overall response including extrahepatic lesions by systemic therapy, which is similar to RECIST ormodified RECIST. We hope this new treatment response criteria, RECICL, proposed by the Liver Cancer Study Group of Japan will benefit HCC treatment response evaluation in the setting of daily clinical practice and clinical trials, not only in Japan, but also internationally.
    WILEY, 2016年01月, HEPATOLOGY RESEARCH, 46(1) (1), 3 - 9, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Minami Y, Takita M, Tsurusaki M, Yagyu Y, Ueshima K, Murakami T, Kudo M
    2016年, Hepatol Res (in press)
    [査読有り]

  • Nobuo Kashiwagi, Takamichi Murakami, Masafumi Toguchi, Katsuyuki Nakanishi, Shojiro Hidaka, Hideyuki Fukui, Masatomo Kimura, Mutsukazu Kitano, Noriyuki Tomiyama
    Objectives: To present and characterize CT and MR imaging findings of metastases to the parotid nodes. Methods: CT (n=10) and MR (n=11) images from 14 patients with metastases to the parotid nodes were reviewed. The primary tumour sites were the ocular adnexa in five patients, facial skin in four patients, upper aerodigestive tract in four patients and thyroid gland in one patient. CT and MR images were evaluated with emphasis on the size and number of parotid tumours, their location in the parotid gland, the presence of associated clinically pathological cervical nodes or previous history of cervical node metastasis, margin characteristics and the presence of central necrosis. Results: A total of 18 tumours were identified in 14 patients, with an average maximal cross-sectional diameter of 19mm (7-44 mm). 12 patients had a single parotid tumour and 2 patients had unilateral multiple tumours; 12 tumours in 10 patients were located in the parotid tail, 6 tumours in 4 patients were located in the superficial lobe and no tumour was noted in the deep lobe. In the superficial lobe, four of six tumours were located in the pretragal area. Three of nine patients whose primary sites were the ocular adnexa or skin had associated clinically pathological cervical nodes. None of these patients had a previous history of cervical node metastasis. All five patients with other primary sites had associated pathological cervical nodes or a history of such. 11 tumours had well-defined margins and 7 tumours had ill-defined margins. Post-contrast images showed central necrosis in 2 of 11 tumours. Conclusions: Metastases to the parotid nodes tend to present as solitary parotid masses with two preferential sites.
    BRITISH INST RADIOLOGY, 2016年, DENTOMAXILLOFACIAL RADIOLOGY, 45(8) (8), 英語
    [査読有り]
    研究論文（学術雑誌）

  • Sakaguchi K, Hosono M, Imamura T, Takahara N, Hayashi M, Yakushiji Y, Ishii K, Murakami T
    2016年, EJNMMI Physics (in press)
    [査読有り]

  • Yuki Makino, Yasuharu Imai, Takumi Igura, Sachiyo Kogita, Yoshiyuki Sawai, Kazuto Fukuda, Takayuki Iwamoto, Junya Okabe, Manabu Takamura, Norihiko Fujita, Masatoshi Hori, Tetsuo Takehara, Masatoshi Kudo, Takamichi Murakami
    Background and Aims: Extracted-overlay fusion imaging is a novel computed tomography/magnetic resonance-ultrasonography (CT/MR-US) imaging technique in which a target tumor with a virtual ablative margin is extracted from CT/MR volume data and synchronously overlaid on US images. We investigated the applicability of the technique to intraoperative evaluation of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). Methods: This retrospective study analyzed 85 HCCs treated with RFA using extracted-overlay fusion imaging for guidance and evaluation. To perform RFA, an electrode was inserted targeting the tumor and a virtual 5-mm ablative margin overlaid on the US image. Following ablation, contrast-enhanced US (CEUS) was performed to assess the ablative margin, and the minimal ablative margins were categorized into three groups: (I) margin <0 mm (protrusion), (II) margin 0 to <5 mm, and (III) margin >= 5 mm. Margin assessment was based on the positional relationship between the overlaid tumor plus margin and the perfusion defect of the ablation zone. Tumors in group I underwent repeat ablation until they were in groups II or III. The final classifications were compared with those obtained by retrospectively created fusion images of pre- and post-RFA CT or MR imaging (CT-CT/MR-MR fusion imaging). Results: Treatment evaluation was impossible using CEUS in six HCCs because the tumors were located far below the body surface. Of the remaining 79 HCCs, the categorizations of minimal ablative margins between CEUS extracted-overlay fusion imaging and CT-CT/MR-MR fusion imaging were in agreement for 72 tumors (91.1%) (Cohen's quadratic-weighted kappa coefficient 0.66, good agreement, p<0.01). Conclusions: Extracted-overlay fusion imaging combined with CEUS is feasible for the evaluation of RFA and enables intraoperative treatment evaluation without the need to perform contrast-enhanced CT. Copyright (C) 2016 S. Karger AG, Basel
    KARGER, 2016年, LIVER CANCER, 5(4) (4), 269 - 279, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Mika Yamamuro, Kanako Yamada, Yoshiyuki Asai, Koji Yamada, Yoshiaki Ozaki, Masao Matsumoto, Takamichi Murakami
    Mammography, the most effective early breast cancer detection technique, is associated with the risk of missed lesions in dense breasts, and excessive X-ray exposure. Accurate estimations of glandularity and radiation dose are important during screening. We propose a novel, inexpensive method for accurate glandularity quantification using pixel values in clinical digital mammograms and X-ray exposure spectra. Glandularities were calculated for 314 mammograms in Japanese women, and the Dance formula c-factor was applied to estimate breast doses. To investigate the relationship between breast thickness and missed lesions, images were classified into four categories based on the rate of missed lesions, and correlated with breast thickness. Glandularity decreased with increasing compressed breast thickness, indicating that commonly used breast doses (assumed 50% glandularity) significantly overestimate thin breasts and underestimate thick breasts. The missed lesion rate was higher for thinner compressed breast thicknesses. Accurate glandularity estimation could thus promote individualized screening mammography.
    SPRINGER INT PUBLISHING AG, 2016年, BREAST IMAGING, IWDM 2016, 9699, 377 - 384, 英語
    [査読有り]
    研究論文（国際会議プロシーディングス）

  • Yasuyuki Yamashita, Sadayuki Murayama, Masahiro Okada, Yoshiyuki Watanabe, Masako Kataoka, Yasushi Kaji, Keiko Imamura, Yasuo Takehara, Hiromitsu Hayashi, Kazuko Ohno, Kazuo Awai, Toshinori Hirai, Kazuyuki Kojima, Shuji Sakai, Naofumi Matsunaga, Takamichi Murakami, Kengo Yoshimitsu, Toshifumi Gabata, Kenji Matsuzaki, Eriko Tohno, Yasuhiro Kawahara, Takeo Nakayama, Shuichi Monzawa, Satoru Takahashi
    Diagnostic imaging is undoubtedly important in modern medicine, and final clinical decisions are often made based on it. Fortunately, Japan has the highest numbers of diagnostic imaging instruments, such as CT and MRI devices, and boasts easy access to them as well as a high level of diagnostic accuracy. In consequence, a very large number of imaging examinations are performed, but diagnostic instruments are installed in so many medical facilities that expert management of these examinations tends to be insufficient. Particularly, in order to avoid risks, clinicians have recently become indifferent to indications of imaging modalities and tend to rely on CT or MRI resulting in increasing the number of imaging examinations in Japan. This is a serious problem from the viewpoints of avoidance of unnecessary exposure and medical economy. Under these circumstances, the Japan Radiological Society and Japanese College of Radiology jointly initiated the preparation of new guidelines for diagnostic imaging. However, the field of diagnostic imaging is extremely wide, and it is impossible to cover all diseases. Therefore, in drafting the guidelines, we selected important diseases and focused on "showing evidence and suggestions in the form of clinical questions (CQs)" concerning clinically encountered questions and "describing routine imaging techniques presently considered to be standards to guarantee the quality of imaging examinations". In so doing, we adhered to the basic principles of assuming the readers to be "radiologists specializing in diagnostic imaging", "simultaneously respecting the global standards and attending to the situation in Japan", and "making the guidelines consistent with those of other scientific societies related to imaging". As a result, the guidelines became the largest ever, consisting of 152 CQs, nine areas of imaging techniques, and seven reviews, but no other guidelines in the world summarize problems concerning diagnostic imaging in the form of CQs. In this sense, the guidelines are considered to reflect the abilities of diagnostic radiologists in Japan. The contents of the guidelines are essential knowledge for radiologists, but we believe that they are also of use to general clinicians and clinical radiological technicians. While the number and contents of CQs are still insufficient, and while chapters such as those on imaging in children and emergency imaging need to be supplemented, the guidelines will be serially improved through future revisions. Lastly, we would like to extend our sincere thanks to the 153 members of the drafting committee who authored the guidelines, 12 committee chairpersons who coordinated their efforts, six members of the secretariat, and affiliates of related scientific societies who performed external evaluation.
    SPRINGER, 2016年01月, JAPANESE JOURNAL OF RADIOLOGY, 34(1) (1), 43 - 79, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masakatsu Tsurusaki, Keitaro Sofue, Hiroyoshi Isoda, Masahiro Okada, Kazuhiro Kitajima, Takamichi Murakami
    Gadoxetic acid-enhanced magnetic resonance imaging (MRI) has an important role in preoperative evaluation of hepatocellular carcinoma (HCC). However, no studies have prospectively performed intraindividual comparison of gadoxetic acid-enhanced 3T MRI and multidetector-row computed tomography (MDCT) with histopathological examination for the detection of HCCs. We prospectively compared the efficacies of gadoxetic acid-enhanced MRI and multiphasic contrast-enhanced MDCT with that of histopathological examination, used as a reference standard, for the detection of HCC in surgical candidates. The study was approved by the institutional review boards at each of four centers. Patients scheduled to undergo multiphasic CT, gadoxetic acid-enhanced MRI, and liver surgery were prospectively included in this study. The diagnostic abilities of MRI and CT were evaluated and compared on the basis of sensitivity and positive predictive value for detection of and differentiation between HCCs and benign lesions. Fifty-four patients with 83 histopathologically confirmed HCCs were included in the study. Combined interpretation of the dynamic and hepatobiliary phases of gadoxetic acid-enhanced MRI showed statistically higher sensitivity for lesion detection (83 %) than did interpretation of multiphasic MDCT images (70 %; p < 0.001). The mean area under each alternative free-response receiver operating characteristics curve was significantly higher for MR images (0.927) than for CT images (0.864, p < 0.01). The sensitivity for preoperative detection of HCCs was higher for gadoxetic acid-enhanced MRI than for multiphasic MDCT imaging.
    SPRINGER JAPAN KK, 2016年01月, JOURNAL OF GASTROENTEROLOGY, 51(1) (1), 71 - 79, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tetsuro Araki, Mizuki Nishino, Wei Gao, Josee Dupuis, Gary M. Hunninghake, Takamichi Murakami, George R. Washko, George T. O'Connor, Hiroto Hatabu
    To investigate CT appearance and size of the thymus in association with participant characteristics. 2540 supposedly healthy participants (mean age 58.9 years, 51 % female) were evaluated for the CT appearance of thymic glands with four-point scores (according to the ratio of fat and soft tissue), size and morphology. These were correlated with participants' age, sex, BMI and smoking history. Of 2540 participants, 1869 (74 %) showed complete fatty replacement of the thymus (Score 0), 463 (18 %) predominantly fatty attenuation (Score 1), 172 (7 %) half fatty and half soft-tissue attenuation (Score 2) and 36 (1 %) solid thymic gland with predominantly soft-tissue attenuation (Score 3). Female participants showed less fatty degeneration of the thymus with higher thymic scores within age 40-69 years (P < 0.001). Participants with lower thymic scores showed higher BMI (P < 0.001) and were more likely to be former smokers (P < 0.001) with higher pack-years (P = 0.04). Visual assessment with four-point thymic scores revealed a sex difference in the fatty degeneration of the thymus with age. Women show significantly higher thymic scores, suggesting less fat content of the thymus, during age 40-69 years. Cigarette smoking and high BMI are associated with advanced fatty replacement of the thymus. aEuro cent 74 % of participants (mean age 58.9 years) demonstrated complete fatty thymus. aEuro cent Women show less fatty thymus compared to men at ages 40-69 years. aEuro cent Smoking and high BMI are associated with advanced fatty degeneration in thymus.
    SPRINGER, 2016年01月, EUROPEAN RADIOLOGY, 26(1) (1), 15 - 24, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Chisa Hosokawa, Kazunari Ishii, Yuichi Kimura, Tomoko Hyodo, Makoto Hosono, Kenta Sakaguchi, Kimio Usami, Kenji Shimamoto, Yuzuru Yamazoe, Takamichi Murakami
    The goal of this study was to clarify whether binding potential (BP) images using C-11-Pittsburgh compound B (C-11-PiB) and dynamic PET can reliably detect cortical amyloid deposits for patients whose C-11-PiB PET static images are ambiguous and whether visual ratings are affected by white matter retention. Methods: Static and BP images were constructed for 85 consecutive patients with cognitive impairment after C-11-PiB dynamic PET. Cortical uptake was visually assessed as positive, negative, or equivocal for both types of images. Quantitatively, the standardized uptake value ratio (SUVR) from the static image, the nondisplaceable BP from the dynamic image for mean gray matter uptake, and the ratio of gray matter uptake to white matter retention were compared among C-11-PiB-positive, C-11-PiB-equivocal, and C-11-PiB-negative groups. Results: Forty-three scans were visually assessed as C-11-PiB-positive in both the static and the BP images. Ten scans were C-11-PiB-equivocal in the static images. In 8 of them, the BP images were C-11-PiB-positive, whereas the other 2 were C-11-PiB-equivocal. Thirty-two scans were assessed as C-11-PiB-negative in the static images. In the BP images, 4 were C-11-PiB-positive and 2 were C-11-PiB-equivocal. The mean gray matter uptake of C-11-PiB in SUVR and nondisplaceable BP, respectively, showed statistically significant differences among the C-11-PiB-positive, C-11-PiB-equivocal, and C-11-PiB-negative groups. The ratio of gray matter uptake to white matter retention was lower in the BP images than static images from the C-11-PiB-negative and C-11-PiB-equivocal groups, whereas it was higher in the C-11-PiB-positive group. Conclusion: C-11-PiB PET BP images can clarify visual interpretation of clinical static C-11-PiB-equivocal images by reducing the interference of nonspecific white matter retention. We conclude that C-11-PiB-equivocal PET findings on static images reflect cortical amyloid deposits, which can be verified using BP images. Furthermore, quantitative assessments, such as SUVR and nondisplaceable BP, are of no use for correctly rating equivocal visual findings.
    SOC NUCLEAR MEDICINE INC, 2015年12月, JOURNAL OF NUCLEAR MEDICINE, 56(12) (12), 1910 - 1915, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 甲斐田 勇人, 石井 一成, 村上 卓道, 田原 宣広, 本多 亮博, 福本 義弘, 石橋 正敏
    (一社)日本核医学会, 2015年11月, 核医学, 52(4) (4), 403 - 403, 日本語

  • SungWoon Im, Ryuichiro Ashikaga, Yukinobu Yagyu, Tetsuya Wakayama, Mitsuharu Miyoshi, Tomoko Hyodo, Izumi Imaoka, Seishi Kumano, Kazunari Ishii, Takamichi Murakami
    The purpose of this study was to investigate the usefulness of T1W black-blood Cube (BB Cube) and T1W BB Cube fluid-attenuated inversion recovery (BB Cube-FLAIR) sequences for contrast-enhanced brain imaging, by evaluating flow-related artefacts, detectability, and contrast ratio (CR) of intracranial lesions among these sequences and T1W-SE. Phantom studies were performed to determine the optimal parameters of BB Cube and BB Cube-FLAIR. A clinical study in 23 patients with intracranial lesions was performed to evaluate the usefulness of these two sequences for the diagnosis of intracranial lesions compared with the conventional 2D T1W-SE sequence. The phantom study revealed that the optimal parameters for contrast-enhanced T1W imaging were TR/TE = 500 ms/minimum in BB Cube and TR/TE/TI = 600 ms/minimum/300 ms in BB Cube-FLAIR imaging. In the clinical study, the degree of flow-related artefacts was significantly lower in BB Cube and BB Cube-FLAIR than in T1W-SE. Regarding tumour detection, BB Cube showed the best detectability; however, there were no significant differences in CR among the sequences. At 1.5 T, contrast-enhanced BB Cube was a better imaging sequence for detecting brain lesions than T1W-SE or BB Cube-FLAIR. aEuro cent Cube is a single-slab 3D FSE imaging sequence. aEuro cent We applied a black-blood (BB) imaging technique to T1W Cube. aEuro cent At 1.5 T, contrast-enhanced T1W BB Cube was valuable for detecting brain lesions.
    SPRINGER, 2015年11月, EUROPEAN RADIOLOGY, 25(11) (11), 3175 - 3186, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Kazushi Numata, Hiroyuki Fukuda, Hiromi Nihonmatsu, Masaaki Kondo, Akito Nozaki, Makoto Chuma, Manabu Morimoto, Takashi Oshima, Masahiro Okada, Takamichi Murakami, Shigeo Takebayashi, Shin Maeda, Yoshiaki Inayama, Masayuki Nakano, Katsuaki Tanaka
    We evaluated the use of tumor vessel patterns observed during arterial-phase contrast-enhanced ultrasonography (US) to differentiate regenerative nodules (RN) from early hepatocellular carcinoma (HCC) or high-grade dysplastic nodules (HGDN) in patients with chronic liver disease. Pathologically confirmed lesions (83 early HCC, 6 HGDN, and 13 RN with mean maximal diameters of 15.4, 15.3, and 16.2 mm, respectively) were enrolled in this retrospective study. We performed contrast-enhanced US using a perflubutane-based contrast agent. We then classified the tumor vessels observed during the arterial phase of contrast-enhanced US into two patterns: peripheral vessels (centripetal pattern) and central vessels (centrifugal pattern). Eighty-one (97.6%) of the 83 early HCC exhibited various enhancement patterns (hypovascular, 44.6%; isovascular, 25.3%; and hypervascular, 27.7%) and a peripheral vessel pattern, while the remaining 2 lesions (2.4%) exhibited hypovascular enhancement and a central vessel pattern. All 6 HGDN lesions were hypovascular with a peripheral vessel pattern. Twelve (92.3%) of the 13 RN were hypovascular with a central vessel pattern, and the remaining one (7.7%) was hypervascular with a central vessel pattern. When lesions exhibiting a central vessel pattern during arterial-phase contrast-enhanced US were diagnosed as RN, the sensitivity, specificity, and accuracy of these diagnoses were 100%, 97.8%, and 98.0%, respectively. The tumor vessel patterns observed during arterial-phase contrast-enhanced US may be useful for differentiating RN from early HCC or HGDN in patients with chronic liver disease.
    SPRINGER, 2015年10月, ABDOMINAL IMAGING, 40(7) (7), 2372 - 2383, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 上腸間膜静脈血栓症による急性腸管虚血に対しTIPSを施行した1例
    沼本 勲男, 鶴崎 正勝, 柳生 行伸, 渡口 真史, 山川 美帆, 任 誠雲, 松木 充, 村上 卓道, 萩原 智, 工藤 正俊, 吉藤 竹仁, 船内 正憲
    (一社)日本インターベンショナルラジオロジー学会, 2015年09月, IVR: Interventional Radiology, 30(3) (3), 283 - 283, 日本語

  • 膵癌のFDG集積とmTOR関連マーカーとの相関性に関する分子病理学的検討
    甲斐田 勇人, 東 公一, 河原 明彦, 安永 昌史, 服部 聡, 倉田 精二, 廣瀬 靖光, 鹿毛 政義, 石井 一成, 村上 卓道, 石橋 正敏
    (一社)日本核医学会, 2015年09月, 核医学, 52(3) (3), 248 - 248, 日本語

  • PiB陰性例の18F-FDG PETによる脳代謝分布の検討
    細川 知紗, 石井 一成, 若林 雄一, 兵頭 朋子, 花田 一志, 甲斐田 勇人, 細野 眞, 木村 裕一, 村上 卓道
    (一社)日本核医学会, 2015年09月, 核医学, 52(3) (3), 262 - 262, 日本語

  • アミロイドイメージングにおける組織放射能時間曲線に対するパターン認識による参照領域設定アルゴリズム
    木村 裕一, 山田 誉大, 細川 知紗, 石井 一成, 村上 卓道
    (一社)日本核医学会, 2015年09月, 核医学, 52(3) (3), 293 - 293, 日本語

  • 超急性期脳梗塞症例に対する頭部単純CT画像を用いたコンピューター支援診断システムの開発
    渡邊 翔太, 坂口 健太, 細野 眞, 石井 一成, 村上 卓道
    (公社)日本放射線技術学会, 2015年09月, 日本放射線技術学会雑誌, 71(9) (9), 896 - 896, 日本語

  • Tetsuro Araki, Mizuki Nishino, Oscar E. Zazueta, Wei Gao, Josee Dupuis, Yuka Okajima, Jeanne C. Latourelle, Ivan O. Rosas, Takamichi Murakami, George T. O'Connor, George R. Washko, Gary M. Hunninghake, Hiroto Hatabu
    Objective: To investigate the prevalence and distribution of paraseptal emphysema on chest CT images in the Framingham Heart Study (FHS) population, and assess its impact on pulmonary function. Also pursued was the association with interstitial lung abnormalities. Materials and methods: We assessed 2633 participants in the FHS for paraseptal emphysema on chest CT. Characteristics of the participants, including age, sex, smoking status, clinical symptoms, and results of pulmonary function tests, were compared between those with and without paraseptal emphysema. The association between paraseptal emphysema and interstitial lung abnormalities was investigated. Results: Of the 2633 participants, 86 (3%) had pure paraseptal emphysema (defined as paraseptal emphysema with no other subtypes of emphysema other than paraseptal emphysema or a very few centrilobular emphysema involved) in at least one lung zone. The upper zone of the lungs was almost always involved. Compared to the participants without paraseptal emphysema, those with pure paraseptal emphysema were significantly older, and were more frequently male and smokers (mean 64 years, 71% male, mean 36 pack-years, P < 0.001) and had significantly decreased FEV1/FVC% (P = 0.002), and diffusion capacity of carbon monoxide (DLCO) (P = 0.002). There was a significant association between pure paraseptal emphysema and interstitial lung abnormalities (P < 0.001). Conclusions: The prevalence of pure paraseptal emphysema was 3% in the FHS population, predominantly affects the upper lung zone, and contributes to decreased pulmonary function. Cigarette smoking, aging, and male gender were the factors associated with the presence of paraseptal emphysema. Significant association between paraseptal emphysema and interstitial lung abnormalities was observed. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
    ELSEVIER IRELAND LTD, 2015年07月, EUROPEAN JOURNAL OF RADIOLOGY, 84(7) (7), 1413 - 1418, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 肝細胞癌の診断・治療の最前線 ダイナミックCT・MRI診断
    村上卓道, 朝戸信行, 熊野正士, 鶴﨑正勝
    2015年06月, 消化器外科, 38(6) (6), 877 - 886
    [査読有り]

  • NAFLDにおけるDual energy CTを用いた肝脂肪変性定量評価の有用
    岡部 純弥, 澤井 良之, 福田 和人, 井倉 技, 小来田 幸世, 今井 康陽, 磯谷 圭介, 米澤 稔, 藤田 典彦, 兵頭 朋子, 辻川 華子, 阿部 時也, 橋口 明典, 坂元 亨宇, 村上 卓道
    (一社)日本肝臓学会, 2015年04月, 肝臓, 56(Suppl.1) (Suppl.1), A359 - A359, 日本語

  • Nobuo Kashiwagi, Takashi Fujii, Kinji Nishiyama, Katsuyuki Nakanishi, Noriyuki Tomiyama, Yukinobu Yagyu, Masakatsu Tsurusaki, Mutsukazu Kitano, Takamichi Murakami
    A case of advanced parotid cancer in which long-term control was achieved by superselective intra-arterial cisplatin infusion with concomitant radiotherapy is reported. A 63-year-old woman with parotid squamous cell carcinoma was referred to our hospital. Magnetic resonance images revealed extraparotid extension of the tumor, indicating that complete resection would be difficult. Consequently, intra-arterial cisplatin infusion with concomitant radiotherapy was planned as an alternative therapy. Superselective intra-arterial infusion of cisplatin (100 mg/m(2)) was performed six times, at intervals of 7-9 days. The arteries chosen for superselective infusion were the posterior auricular artery, the transverse facial artery and the intrinsic parotid artery originating directly from the external carotid artery. Concurrently, external radiotherapy of a total of 50 Gy in 25 fractions was also performed. The patient achieved a complete response and has remained free of disease recurrence 5 years after treatment. Intra-arterial cisplatin infusion with concomitant radiotherapy can be a practical option for patients with unresectable parotid squamous cell carcinoma.
    OXFORD UNIV PRESS, 2015年04月, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 45(4) (4), 378 - 380, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 膵頭十二指腸切除後膵液瘻に対する予測因子としての内臓脂肪量測定の有用性
    荒木麻利子, 松本正孝, 中多靖幸, 亀井敬子, 石川 原, 中居卓也, 村上卓道, 竹山宣典
    2015年03月, 近畿大学医学雑誌, 39(3) (3), 125 - 132

  • Minori Onoda, Tomoko Hyodo, Takamichi Murakami, Masahiro Okada, Tatsuro Uto, Masatoshi Hori, Tosiaki Miyati
    Objective: To compare signal intensity (SI) correction using scale and rescale slopes with SI correction using SIs of spleen and muscle for quantifying multiphase hepatic contrast enhancement with Gd-EOB-DTPA by assessing their correlation with T-1 values generated from Look-Locker turbo-field-echo (LL-TFE) sequence data (ER-T-1). Materials and methods: Thirty patients underwent Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) in this prospective clinical study. For each patient, breath-hold T-1-weighted fat-suppressed three-dimensional (3D) gradient echo sequences (e-THRIVE) were acquired before and 2 (first phase), 10 (second phase), and 20 min (third phase) after intravenous Gd-EOB-DTPA. Look-Locker turbo-fieldecho (LL-TFE) sequences were acquired before and 1.5 (first phase), 8 (second phase), and 18 min (third phase) postcontrast. The liver parenchyma enhancement ratios (ER) of each phase were calculated using the SI from e-THRIVE sequences (ER-SI) and the T-1 values generated from LL-TFE sequence data (ER-T-1) respectively. ER-SIs were calculated in three ways: (1) comparing with splenic SI (ER-SI-s), (2) comparing with muscle SI (ER-SI-m), (3) using scale and rescale slopes obtained from DICOM headers (ER-SI-c), to eliminate the effects of receiver gain and scaling. For each of the first, second and third phases, correlation and agreement were assessed between each ER-SI and ER-T-1. Results: In the first phase, all ER-SIs correlated weakly with ER-Ti. In the second and third phases, ER-SI-c showed a stronger linear correlation with ER-Ti (r(2) =0.71-0.72, p <0.01) than did ER-SI-s (r(2) =0.37-0.39, p <0.01) or ER-SI-m (r(2) =0.30-0.41, p <0.01). Conclusion: SI correction using scale and rescale slopes from DICOM data is the most acceptable algorithm for evaluating delayed-phase Gd-EOB-DTPA hepatic enhancement. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
    ELSEVIER IRELAND LTD, 2015年03月, EUROPEAN JOURNAL OF RADIOLOGY, 84(3) (3), 339 - 345, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Norihiro Kokudo, Kiyoshi Hasegawa, Masaaki Akahane, Hiroshi Igaki, Namiki Izumi, Takafumi Ichida, Shinji Uemoto, Shuichi Kaneko, Seiji Kawasaki, Yonson Ku, Masatoshi Kudo, Shoji Kubo, Tadatoshi Takayama, Ryosuke Tateishi, Takashi Fukuda, Osamu Matsui, Yutaka Matsuyama, Takamichi Murakami, Shigeki Arii, Masatoshi Okazaki, Masatoshi Makuuchi
    The 3rd version of Clinical Practice Guidelines for Hepatocellular Carcinoma was revised by the Japan Society of Hepatology, according to the methodology of evidence-based medicine, which was published in October 2013 in Japanese. Here, we briefly describe new or changed recommendations with a special reference to the two algorithms for surveillance, diagnosis, and treatment.
    WILEY-BLACKWELL, 2015年02月, HEPATOLOGY RESEARCH, 45(2) (2), 123 - 127, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masahiro Okada, Takamichi Murakami, Norihisa Yada, Kazushi Numata, Minori Onoda, Tomoko Hyodo, Tatsuo Inoue, Kazunari Ishii, Masatoshi Kudo
    PurposeTo compare four imaging approaches in cirrhotic estimation; pre-enhancement T1 relaxation time (T1RT), reduction rate (RR) of T1RT, signal-based liver-to-muscle ratio (L/M ratio) on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI), and liver stiffness measurement (LSM) of US elastography. Materials and MethodsConsecutive 58 patients with chronic liver diseases who underwent both Gd-EOB-DTPA-enhanced MRI and FibroScan were analyzed. Four imaging approaches were evaluated by fibrosis score from liver biopsy and receiver operating characteristic (ROC) analysis. ResultsRR was found to be inversely correlated with LSM (r=-0.65). RR decreased with degree of fibrosis (F0-F1, 58.56.2%, versus F2-F3-F4, 48.8 +/- 11.7%, P=0.010, F0-F1-F2, 58.2 +/- 6.2% versus F3-F4, 45.5 +/- 12.3%, P=0.010 and F0-F1, 58.5 +/- 6.2%, versus F2-F3, 52.1 +/- 12.0%, P=0.0038). LSM increased with degree of fibrosis (F0-F1, 5.4 +/- 2.2 kPa versus F2-F3-F3, 19.3 +/- 15.5 kPa, P=0.0011 and F0-F1-F2, 6.8 +/- 3.6 kPa versus F3-F4, 23.8 +/- 17.1 kPa, P=0.0029 and F0-F1, 5.4 +/- 2.2 kPa, versus F2-F3, 11.4 +/- 7.2 kPa, P=0.0098). Area under ROC curves were 0.83 (F3-F4), 0.72 (F2-F3-F4), 0.68 (F2-F3) for RR and 0.83 (F3-F4), 0.88 (F2-F3-F4), 0.81 (F2-F3) for LSM in discriminating between patients with fibrosis. ConclusionThe capability by LSM was better than those by RR of T1RT, pre-enhancement T1RT, and L/M ratio to differentiate F2, but LSM and RR of T1RT showed the same value to differentiate F3. J. Magn. Reson. Imaging 2015;41:329-338.(c) 2013 Wiley Periodicals, Inc.
    WILEY-BLACKWELL, 2015年02月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 41(2) (2), 329 - 338, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Chisa Hosokawa, Kazunari Ishii, Tomoko Hyodo, Kenta Sakaguchi, Kimio Usami, Kenji Shimamoto, Yuzuru Yamazoe, Makoto Hosono, Kazushi Hanada, Masami Ueda, Kazuma Saigo, Takamichi Murakami
    We have encountered occasional equivocal findings when assessing cerebral cortical amyloid retention with C-11-Pittsburgh compound B (PiB) PET. We investigated the diagnostic significance of equivocal PiB PET findings. This retrospective study included 101 consecutive patients complaining of cognitive disorders (30 Alzheimer's disease, 25 mild cognitive impairment, 8 Lewy body disease, 7 frontotemporal lobar degeneration, 31 others) who underwent both C-11-PiB PET and F-18-fluorodeoxy-d-glucose (FDG) PET. We visually classified PiB-positive, PiB-equivocal or PiB-negative ratings according to cortical uptake. For quantitative assessments of PiB PET, standard uptake values referred to cerebellar cortex (SUVR) were calculated in regional template volume of interests (frontal, temporoparietal, precuneus/posterior cingulate cortex, cerebral white matter and cerebellar cortex). The results of visual assessment were compared with the regional and mean cortical SUVRs and cortical-to-white matter ratio of PiB uptake, as well as clinical and FDG PET findings. Among the 101 scans, 41 were PiB negative, 11 were PiB equivocal, and 49 were rated PiB positive in the visual assessments. The mean cortical SUVR and cortical-to-white matter ratio were 0.97 +/- A 0.07 and 0.57 +/- A 0.21 in PiB-negative, 1.51 +/- A 0.17 and 0.75 +/- A 0.06 in PiB equivocal and 2.10 +/- A 0.33 and 0.97 +/- A 0.11 in PiB-positive group, respectively. Nine of 11 subjects with PiB-equivocal findings had cognitive impairments and FDG distribution compatible with Alzheimer's disease or dementia with Lewy bodies. We considered equivocal visual findings on PiB PET equivalent to PiB-positive with slight cortical uptake. In addition, slight cortical amyloid deposits were considered to cause cerebral metabolic abnormality and cognitive impairment. Although mean cortical SUVR was more sensitive than visual assessment because of low cortical-to-white matter contrast due to non-specific accumulation in white matter, it is important not to overlook small amounts of cortical uptake of PiB in visual inspection for exact diagnosis.
    SPRINGER, 2015年02月, ANNALS OF NUCLEAR MEDICINE, 29(2) (2), 164 - 169, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tetsuro Araki, Mizuki Nishino, Wei Gao, Josée Dupuis, George R. Washko, Gary M. Hunninghake, Takamichi Murakami, George T. O'Connor, Hiroto Hatabu
    Purpose: To investigate the prevalence and CT image characteristics of anterior mediastinal masses in a population-based cohort and their association with the demographics of the participants. Materials and methods: Chest CT scans of 2571 Framingham Heart Study participants (mean age 58.9 years, 51% female) were evaluated by two board-certified radiologists with expertise in thoracic imaging for the presence of anterior mediastinal masses, their shape, contour, location, invasion of adjacent structures, fat content, and calcification. For participants with anterior mediastinal masses, a previous cardiac CT scan was reviewed for interval size change of the masses, when available. The demographics of the participants were studied for any association with the presence of anterior mediastinal masses. Results: Of 2571, 23 participants (0.9%, 95% CI: 0.6-1.3) had anterior mediastinal masses on CT. The most common CT characteristics were oval shape, lobular contour, and midline location, showing soft tissue density (median 32.1. HU). Fat content was detected in a few cases (9%, 2/23). Six out of eight masses with available prior cardiac CT scans demonstrated an interval growth over a median period of 6.5 years. No risk factors for anterior mediastinal masses were detected among participants' demographics, including age, sex, BMI, and cigarette smoking. Conclusions: The prevalence of anterior mediastinal masses is 0.9% in the Framingham Heart Study. Those masses may increase in size when observed over 5-7 years. Investigation of clinical significance in incidentally found anterior mediastinal masses with a longer period of follow-up would be necessary.
    Elsevier Ltd, 2015年01月, European Journal of Radiology Open, 2, 26 - 31, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yasunori Minami, Tomohiro Minami, Hirokazu Chishina, Tadaaki Arizumi, Masahiro Takita, Satoshi Kitai, Norihisa Yada, Satoru Hagiwara, Masakatsu Tsurusaki, Yukinobu Yagyu, Kazuomi Ueshima, Naoshi Nishida, Takamichi Murakami, Masatoshi Kudo
    Objective: To investigate whether balloon-occluded transcatheter arterial chemoembolization (b-TACE) can produce a more dense accumulation of iodized oil in various stages of hepatocellular carcinoma (HCC), from single to uncountable, to overcome inferior local control. Materials and Methods: We studied 27 patients with HCC, including single to uncountable multiple lesions, who underwent b-TACE between August 2013 and April 2015. Dynamic CT was performed at baseline and 1-3 months after b-TACE. The treatment effect (TE) after b-TACE was evaluated using the Response Evaluation Criteria in Cancer of the Liver (RECICL) proposed by the Liver Cancer Study Group of Japan. Results: In the countable HCC group, contrast-enhanced CT demonstrated RECICL TE4 in 43.8% (14/32), TE3 in 12.5% (4/32), TE2 in 37.5% (12/32), and TEl in 6.3% (2/32) of patients. For the TACE-naive cohort, the objective response rate was 52.9%. The objective response rate was 60% for the previously lACE-treated cohort. In the uncountable multiple HCC group, the objective response rate was 0% (0/10), with progressive disease in 90% (9/10) of patients. Conclusion: Our observations suggested that b-TACE did not reduce the efficacy of retreatment for HCC with an insufficient outcome from conventional TACE, but it could not improve the efficacy of treatment for uncountable multiple HCCs. (C) 2015 S. Karger AG, Basel
    KARGER, 2015年, ONCOLOGY, 89(Suppl2) (Suppl2), 27 - 32, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Chiun Hsu, Bang-Bin Chen, Chien-Hung Chen, Ming-Chih Ho, Jason Chia-Hsien Cheng, Norihiro Kokudo, Takamichi Murakami, Winnie Yeo, Jinsil Seong, Ji-Dong Jia, Kwan-Hyub Han, Ann-Lii Cheng
    A key mission of the Asia-Pacific Primary Liver Cancer Expert (APPLE) Association is to ensure a coherent view for management of hepatocellular carcinoma (HCC) and to advance new treatment for this difficult disease. At the 5th APPLE meeting, held in July 2014 in Taipei, Taiwan, an APPLE consensus development program was established to facilitate discussion among experts in the Asia-Pacific region on pertinent issues for HCC management, including (1) surgery for intermediate/advanced-stage disease, (2) prevention of HCC recurrence after curative treatment, (3) optimizing imaging diagnosis, (4) radiotherapy: current practice and future clinical trials, and (5) the role of cytotoxic chemotherapy. A pre-congress questionnaire was undertaken with the consensus development committee members to help understand the current practice patterns for HCC in the Asia-Pacific region and to identify issues relating to optimal patient care and further clinical trials for which consensus needs to be developed. In this report, the results of the questionnaire are presented, and the pertinent issues identified by each consensus group for further discussion and consensus development are summarized. Copyright (C) 2015 S. Karger AG, Basel
    KARGER, 2015年, LIVER CANCER, 4(2) (2), 96 - 105, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yasunori Minami, Takamichi Murakami, Masayuki Kitano, Toshiharu Sakurai, Naoshi Nishida, Masatoshi Kudo
    Cone-beam CT (CBCT) is generated during a rotational sweep of the C-arm around the patient, and can be a valuable imaging technique, providing in situ cross-sectional imaging. It is easy to evaluate the morphologic characteristics of hepatic arteries from multiple views with the use of various reconstruction techniques, such as maximum intensity projection (MIP) and volume rendering. CBCTangiography is capable of providing more information than the standard 2-dimensional angiography in visualizing hepatocellular carcinomas (HCCs) and targeting tumors though precise microcatheter placement in close proximity to HCCs. It can also be useful in evaluating treatment success at the time of the procedure. It is anticipated that CBCT could reduce radiation exposure, the overall procedure time and contrast material use because it allows immediate feedback for an efficient angiographic procedure. Therefore, CBCT angiography is an exciting technology with the potential to significantly impact the practice of interventional radiology. The purpose of this article is to provide a review of the principles, clinical applications and technique of CBCT angiography for HCC treatment. (C) 2015 S. Karger AG, Basel
    KARGER, 2015年, DIGESTIVE DISEASES, 33(6) (6), 759 - 764, 英語
    [査読有り]

  • Bang-Bin Chen, Takamichi Murakami, Tiffany Ting-Fang Shih, Michiie Sakamoto, Osamu Matsui, Byung-Ihn Choi, Myeong-Jin Kim, Jeong Min Lee, Ren-jie Yang, Meng-Su Zeng, Ran-Chou Chen, Ja-Der Liang
    Current novel imaging techniques in the diagnosis of hepatocellular carcinoma (HCC), with the latest evidence in this field, was discussed at the Asia-Pacific Primary Liver Cancer Expert (APPLE) meeting held in Taipei, Taiwan, in July 2014. Based on their expertise in a specific area of research, the novel imaging group comprised 12 participants from Japan, South Korea, Taiwan, and China and it included 10 abdominal radiologists, one hepatologist, and one pathologist. The expert participants discussed topics related to HCC imaging that were divided into four categories: (i) detection method, (ii) diagnostic method, (iii) evaluation method, and (iv) functional method. Consensus was reached on 10 statements; specific comments on each statement were provided to explain the rationale for the voting results and to suggest future research directions. Copyright (C) 2015 S. Karger AG, Basel
    KARGER, 2015年, LIVER CANCER, 4(4) (4), 215 - 227, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masakatsu Tsurusaki, Takamichi Murakami
    Transcatheter arterial chemoembolization (TACE) is performed worldwide for patients with intermediate-stage hepatocellular carcinoma (HCC). TACE has produced survival advantages in two randomized controlled trials and a meta-analysis, and is currently the mainstay of treatment for this stage of HCC. However, there are currently no global guidelines regarding the dose, choice or combination of cytotoxic agents for TACE; therefore, it is difficult to compare data from different TACE studies. In Japan, most of the TACE procedures have been based on iodized oil as conventional TACE, utilizing the microembolic and drug-carrying characteristic of iodized oil. Superselective TACE with lipiodol is the primary TACE procedure that has reported satisfactory levels of local control associated with a lower risk of complications. Conversely, TACE performed using drug-eluting beads has been widely used in western countries, and this has shown similar tumor response and median survival compared to conventional TACE. Moreover, the combination of TACE and molecular targeted agents is now ongoing to evaluate the synergistic effect. In this review, the indication, technical issues, and complications of TACE are reviewed. Copyright (C) 2015 S. Karger AG, Basel
    KARGER, 2015年, LIVER CANCER, 4(3) (3), 165 - 175, 英語
    [査読有り]

  • Yuki Makino, Yasuharu Imai, Takumi Igura, Masatoshi Hori, Kazuto Fukuda, Yoshiyuki Sawai, Sachiyo Kogita, Norihiko Fujita, Tetsuo Takehara, Takamichi Murakami
    To assess the feasibility of fusion of pre- and post-ablation gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-MRI) to evaluate the effects of radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC), compared with similarly fused CT images This retrospective study included 67 patients with 92 HCCs treated with RFA. Fusion images of pre- and post-RFA dynamic CT, and pre- and post-RFA Gd-EOB-DTPA-MRI were created, using a rigid registration method. The minimal ablative margin measured on fusion imaging was categorized into three groups: (1) tumor protruding outside the ablation zone boundary, (2) ablative margin 0-< 5.0 mm beyond the tumor boundary, and (3) ablative margin a parts per thousand yen5.0 mm beyond the tumor boundary. The categorization of minimal ablative margins was compared between CT and MR fusion images. In 57 (62.0%) HCCs, treatment evaluation was possible both on CT and MR fusion images, and the overall agreement between them for the categorization of minimal ablative margin was good (kappa coefficient = 0.676, P < 0.01). MR fusion imaging enabled treatment evaluation in a significantly larger number of HCCs than CT fusion imaging (86/92 [93.5%] vs. 62/92 [67.4%], P < 0.05). Fusion of pre- and post-ablation Gd-EOB-DTPA-MRI is feasible for treatment evaluation after RFA. It may enable accurate treatment evaluation in cases where CT fusion imaging is not helpful.
    SPRINGER, 2015年01月, ABDOMINAL IMAGING, 40(1) (1), 102 - 111, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Kazunari Ishii, Chisa Hosokawa, Tomoko Hyodo, Kenta Sakaguchi, Kimio Usami, Kenji Shimamoto, Makoto Hosono, Yuzuru Yamazoe, Takamichi Murakami
    There is evidence that some cases of patients with dementia with Lewy bodies (DLB) can demonstrate Alzheimer disease (AD) like reduced glucose metabolism without amyloid deposition. The aim of this study was to clarify whether regional hypometabolism is related to amyloid deposits in the DLB brain and measure the degree of regional hypometabolism. Ten consecutive subjects with DLB and 10 AD patients who underwent both Pittsburgh compound B (PiB)-PET and F-18-fluoro-2-deoxyglucose (FDG)-PET were included in this study. Regional standardized uptake value ratio (SUVR)s normalised to cerebellar cortices were calculated in the FDG- and PiB-PET images. All AD patients and five DLB patients showed amyloid deposits (PiB positive). In the DLB group the parietotemporal and occipital metabolism were significantly lower than those in the AD group but there was no difference between the posterior cingulate hypometabolism between DLB and AD groups. There were no differences in regional glucose metabolism between PiB positive and negative DLB patients. In the DLB brain, it is suggested that decreased regional glucose metabolism is unrelated to amyloid deposits, although the hypometabolic area overlaps with the AD hypometabolic area and the degree of parietotemporal and occipital hypometabolism in DLB brain is much larger than that in AD brain.
    SPRINGER, 2015年01月, ANNALS OF NUCLEAR MEDICINE, 29(1) (1), 78 - 83, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 無水エタノールを用いた経皮経肝門脈塞栓術後に著明な血小板減少を認めた1例
    朝戸 信行, 柳生 行伸, 鶴崎 正勝, 沼本 勲男, 渡口 真史, 山川 美帆, 任 誠雲, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2014年12月, IVR: Interventional Radiology, 29(4) (4), 436 - 436, 日本語

  • Yukinobu Yagyu, Masakatsu Tsurusaki, Kazutoshi Kamiyama, Hajime Kitagaki, Takamichi Murakami
    To evaluate the feasibility and technical aspects of transcatheter arterial chemoembolization (TACE) for non-resectable hepatocellular carcinoma (HCC) using a 3.5-French (Fr) catheter system. This study included 328 consecutive cases of HCC among 232 patients who underwent TACE procedures using both a 3.5-Fr catheter system and a microcatheter fitted to a 3.5-Fr system between April 2009 and November 2011. We assessed the ability to reach the catheter into the proper hepatic artery (PHA), main hepatic branch, segmental artery, and subsegmental or sub-subsegmental artery. The feasibility was rated according to the following factors: (1) the number of arteries that could be used to reach the target artery/total number of procedures using the 3.5-Fr system, (2) the rate of successful completion of the procedures without changing over to the 4-Fr system and (3) the reasons for changing over the 4-Fr system. TACE of the PHA (27 sessions), RHA/LHA (103 sessions), segmental (31 sessions), or subsegmental/sub-subsegmental arteries (162 sessions) was performed. The rate of successfully reaching the target artery using the 3.5-Fr system was 93% (306/328 sessions). We were unable to reach the target artery in 22 sessions, including 11/8/3 procedures targeting the sub-subsegmental artery, subsegmental artery, and RHA/LHA, respectively. We changed over to the 4-Fr system in six sessions; therefore, the rate of successful completion of the procedures without changing over to the 4-Fr system was 98% (322/328 sessions). TACE of the target artery can be successfully performed using the 3.5-Fr system in most patients with HCC.
    SPRINGER, 2014年12月, ABDOMINAL IMAGING, 39(6) (6), 1304 - 1308, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 若林 雄一, 石井 一成, 河内 崇, 細川 知紗, 山川 美帆, 兵頭 朋子, 任 誠雲, 鶴崎 正勝, 足利 竜一郎, 松木 充, 細野 眞, 北村 登, 村上 卓道
    (一社)日本核医学会, 2014年11月, 核医学, 51(4) (4), 438 - 439, 日本語

  • 下肢静脈疾患におけるMR venographyの有用性及び造影CTとのすみわけについて
    朝戸 信行, 保田 知生, 柳生 行伸, 今岡 いずみ, 鶴崎 正勝, 村上 卓道
    (一社)日本脈管学会, 2014年10月, 脈管学, 54(Suppl.) (Suppl.), S164 - S164, 日本語

  • Keitaro Sofue, Masakatsu Tsurusaki, Takamichi Murakami, Shunsuke Onoe, Hiroyuki Tokue, Kentaro Shibamoto, Yasuaki Arai, Kazuro Sugimura
    To compare diagnostic performance in the detection of colorectal liver metastases between 64-detector-row contrast-enhanced CT (CE-CT) alone and the combination of CE-CT and gadoxetic acid-enhanced MRI (EOB-MRI) at 3.0T, and to assess whether EOB-MRI in addition to CE-CT results in a change to initially planned operative strategy. A total of 39 patients (27 men, mean age 65 years) with 85 histopathologically confirmed liver metastases were included. At EOB-MRI, unenhanced (T1- and T2-weighted), dynamic, and hepatocyte-phase images were obtained. At CE-CT, four-phase dynamic contrast-enhanced images were obtained. One on-site reader and three off-site readers independently reviewed both CE-CT alone and the combination of CE-CT and EOB-MRI. Sensitivity, positive predictive value, and alternative free-response receiver operating characteristic (AFROC) method were calculated. Differences in therapeutic strategy before and after the EOB-MRI examination were also evaluated. Sensitivity and area under the AFROC curve with the combination of CE-CT and EOB-MRI were significantly superior to those with CE-CT alone. Changes in surgical therapy were documented in 13 of 39 patients. The combination of CE-CT and EOB-MRI may provide better diagnostic performance than CE-CT alone for the detection of colorectal liver metastases, and EOB-MRI in addition to CE-CT resulted in changes to the planned operative strategy in one-third of the patients. aEuro cent Accurate preoperative imaging is essential for surgical planning and successful hepatic resection. aEuro cent Combination of CE-CT and EOB-MRI is useful to detect colorectal liver metastases. aEuro cent EOB-MRI combined with CE-CT contributes to determine the correct therapeutic strategy.
    SPRINGER, 2014年10月, EUROPEAN RADIOLOGY, 24(10) (10), 2532 - 2539, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 軽症アルツハイマー病の18F-FDG PETと11C-PiB PET検査の経時的画像変化の検討
    細川 知紗, 石井 一成, 兵頭 朋子, 坂口 健太, 宇佐美 公男, 若林 雄一, 鶴崎 正勝, 松木 充, 細野 眞, 村上 卓道
    (一社)日本核医学会, 2014年09月, 核医学, 51(3) (3), 284 - 284, 日本語

  • Masahiro Okada, Tetsuya Wakayama, Norihisa Yada, Tomoko Hyodo, Kazushi Numata, Yuki Kagawa, Daisuke Nishiyama, Keizo Miyakoshi, Takamichi Murakami
    To investigate optimal flip angle (FA) of three-dimensional fat-suppressed T1-weighted image on Gd-EOB-DTPA-enhanced MRI. Forty-five patients with 35 hepatocellular carcinomas (HCCs) and 16 liver metastases (METs) were investigated. Signal-to-noise ratio (SNR), tumor-to-liver contrast (TLC) of HCC and MET, visual image quality (IQ) and lesion conspicuity (LeCo) were evaluated at hepatobiliary phase with different FAs (FA15A degrees-30A degrees-45A degrees-60A degrees in 13 patients, FA5A degrees-10A degrees-15A degrees-20A degrees-25A degrees in 32 patients). TLC gradually showed better in range from FA15A degrees to FA60A degrees and FA5A degrees to FA25A degrees, but SNRs gradually decreased. SNR and TLC-MET at FA15A degrees were significantly better than those at FA45A degrees and FA60A degrees. SNR at FA10A degrees was significantly higher than at FA5A degrees, FA20A degrees, and FA25A degrees. TLC-HCC and TLC-MET at FA5A degrees were inferior to other FAs. IQs and LeCos at FA15A degrees and FA30A degrees were superior to those at FA45A degrees and FA60A degrees. IQs at FA5A degrees and FA25A degrees were significantly lower than those at FA10A degrees-20A degrees, although LeCos for HCC and MET at FA25A degrees were superior to those at FA5A degrees-20A degrees. FA ranging from 10A degrees to 20A degrees is suitable for hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI, to image HCC and MET.
    SPRINGER, 2014年08月, ABDOMINAL IMAGING, 39(4) (4), 694 - 701, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hideko Ohama, Yasuharu Imai, Osamu Nakashima, Sachiyo Kogita, Manabu Takamura, Masatoshi Hori, Yasushi Seki, Yoshiyuki Sawai, Takumi Igura, Kazuto Fukuda, Yuki Makino, Osakuni Morimoto, Masahiko Ohsawa, Michiie Sakamoto, Takamichi Murakami
    Little is known about the difference in enhancement patterns of hepatocellular carcinoma (HCC) during multistep hepatocarcinogenesis between the post-vascular phase of Sonazoid-enhanced ultrasonography (SEUS) and hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine (Gd-EOB-DTPA)-enhanced MRI, as well as uptakes of Sonazoid and Gd-EOB-DTPA by HCC. Seventy patients with 73 histologically proven HCCs (33 hypovascular well-differentiated HCCs and 40 progressed HCCs) and 9 dysplastic nodules (DNs) were enrolled. Enhancement patterns of the lesions on the post-vascular phase of SEUS and hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI were evaluated. Uptakes of Sonazoid and Gd-EOB-DTPA were assessed by Sonazoid enhancement index and EOB enhancement ratio in relation to immunohistochemistry of CD68 and organic anion transporting polypeptide 8 (OATP8), respectively. On the post-vascular phase of SEUS, none of the 9 DNs and 3 of 33 hypovascular well-differentiated HCCs (9 %) were hypoechoic, whereas 3 of 9 DNs (33 %) and 31 of 33 hypovascular well-differentiated HCCs (94 %) showed hypointensity on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI. Of 31 progressed HCCs, 95 and 93 % were hypoechoic and hypointense on the post-vascular phase of SEUS and hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI, respectively. Sonazoid enhancement indexes decreased in progressed HCCs, correlating with lower Kupffer cell numbers (P < 0.001). EOB enhancement ratios decreased in hypovascular well-differentiated and progressed HCCs, as OATP8 expression declined (P < 0.001). In stepwise hepatocarcinogenesis, uptake of Sonazoid starts decreasing later than that of Gd-EOB-DTPA. Although signal reductions on the post-vascular phase of SEUS or hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI suggest HCC, hypoechoic appearance on the post-vascular phase of SEUS might be HCC-specific, particularly progressed HCC.
    SPRINGER JAPAN KK, 2014年06月, JOURNAL OF GASTROENTEROLOGY, 49(6) (6), 1081 - 1093, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 岡田 真広, 兵頭 朋子, 矢田 典久, 安座間 喜明, 伊良波 裕子, 村山 貞之, 工藤 正俊, 村上 卓道
    学研メディカル秀潤社, 2014年05月, 画像診断, 34(7) (7), 753 - 759

  • Comparison between SUV and BP images acquired using 11C-PIB PET: Questionable PIB accumulation in SUV images
    Chisa Hosokawa, Kazunari Ishii, Yuichi Kimura, Kenta Sakaguchi, Makoto Hosono, Takamichi Murakami
    SOC NUCLEAR MEDICINE INC, 2014年05月, JOURNAL OF NUCLEAR MEDICINE, 55, 英語
    [査読有り]

  • H. Takahashi, K. Ishii, C. Hosokawa, T. Hyodo, N. Kashiwagi, M. Matsuki, R. Ashikaga, T. Murakami
    BACKGROUND AND PURPOSE: Alzheimer disease is the most common neurodegenerative disorder with dementia, and a practical and economic biomarker for diagnosis of Alzheimer disease is needed. Three-dimensional arterial spin-labeling, with its high signal-to-noise ratio, enables measurement of cerebral blood flow precisely without any extrinsic tracers. We evaluated the performance of 3D arterial spin-labeling compared with SPECT, and demonstrated the 3D arterial spin-labeled imaging characteristics in the diagnosis of Alzheimer disease. MATERIALS AND METHODS: This study included 68 patients with clinically suspected Alzheimer disease who underwent both 3D arterial spin-labeling and SPECT imaging. Two readers independently assessed both images. Kendall W coefficients of concordance (K) were computed, and receiver operating characteristic analyses were performed for each reader. The differences between the images in regional perfusion distribution were evaluated by means of statistical parametric mapping, and the incidence of hypoperfusion of the cerebral watershed area, referred to as "borderzone sign" in the 3D arterial spin-labeled images, was determined. RESULTS: Readers showed K = 0.82/0.73 for SPECT/3D arterial spin-labeled imaging, and the respective areas under the receiver operating characteristic curve were 0.82/0.69 for reader 1 and 0.80/0.69 for reader 2. Statistical parametric mapping showed that the perisylvian and medial parieto-occipital perfusion in the arterial spin-labeled images was significantly higher than that in the SPECT images. Borderzone sign was observed on 3D arterial spin-labeling in 70% of patients misdiagnosed with Alzheimer disease. CONCLUSIONS: The diagnostic performance of 3D arterial spin-labeling and SPECT for Alzheimer disease was almost equivalent. Three-dimensional arterial spin-labeled imaging was more influenced by hemodynamic factors than was SPECT imaging.
    AMER SOC NEURORADIOLOGY, 2014年05月, AMERICAN JOURNAL OF NEURORADIOLOGY, 35(5) (5), 906 - 911, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hiroto Takahashi, Masahiro Okada, Tomoko Hyodo, Syojiro Hidaka, Yuki Kagawa, Mitsuru Matsuki, Masakatsu Tsurusaki, Takamichi Murakami
    Purpose: To investigate whether low-dose dynamic CT of the liver with iterative reconstruction can reduce both the radiation dose and the amount of contrast medium. Materials and methods: This study was approved by our institutional review board. 113 patients were randomly assigned to one of two groups. Group A/group B (fifty-eight/fifty-five patients) underwent liver dynamic CT at 120/100 kV, with 0/40% adaptive statistical iterative reconstruction (ASIR), with a contrast dose of 600/480 mg I/kg, respectively. Radiation exposure was estimated based on the manufacturer's phantom data. The enhancement value of the hepatic parenchyma, vessels and the tumor-to-liver contrast of hepatocellular carcinomas (HCCs) were compared between two groups. Two readers independently assessed the CT images of the hepatic parenchyma and HCCs. Results: The mean CT dose indices: 6.38/4.04 mGy, the dose-length products: 194.54/124.57 mGy cm, for group A/group B. The mean enhancement value of the hepatic parenchyma and the tumor-to-liver contrast of HCCs with diameters greater than 1 cm in the post-contrast all phases did not differ significantly between two groups (P > 0.05). The enhancement values of vessels in group B were significantly higher than that in group A in the delayed phases (P < 0.05). Two reader's confidence levels for the hepatic parenchyma in the delayed phases and HCCs did not differ significantly between the groups (P > 0.05). Conclusions: Low-dose dynamic CT with ASIR can reduce both the radiation dose and the amount of contrast medium without image quality degradation, compared to conventional dynamic CT without ASIR. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
    ELSEVIER IRELAND LTD, 2014年04月, EUROPEAN JOURNAL OF RADIOLOGY, 83(4) (4), 684 - 691, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 静脈診断 下肢静脈疾患におけるMR venographyの有用性について
    朝戸 信行, 保田 知生, 柳生 行伸, 鶴崎 正勝, 今岡 いずみ, 村上 卓道
    (一社)日本静脈学会, 2014年03月, 静脈学, 25(2) (2), 243 - 243, 日本語

  • 多発結節影を呈した肺アミロイドーシスの1例
    日高 正二朗, 小塚 健倫, 柳生 行伸, 柏木 伸夫, 今岡 いずみ, 松木 充, 足利 竜一朗, 細野 眞, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, 2014年02月, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 39 - 39, 日本語

  • 蠕動運動の月経周期による変化を観察した双角子宮の1例
    荒木 哲朗, 今岡 いずみ, 日高 正二朗, 岡田 真広, 柳生 行伸, 松木 充, 足利 竜一朗, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, 2014年02月, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 40 - 40, 日本語

  • 腫瘤形成した慢性唾液腺炎のFDG-PET/CT所見
    細川 知紗, 柏木 伸夫, 松久保 祐子, 山田 穣, 任 誠雲, 兵頭 朋子, 高橋 洋人, 柳生 行伸, 岡田 真広, 小塚 健倫, 今岡 いずみ, 鶴崎 正勝, 松木 充, 足利 竜一郎, 細野 眞, 石井 一成, 村上 卓道, 筑後 雅章
    (公社)日本医学放射線学会, 2014年02月, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 45 - 45, 日本語

  • MR imaging of hydrogel scleral buckle as a late complication after retinal detachment surgery
    Ashikaga R, Im S, Yagyu Y, Abe K, Ono Y, Matsumoto C, Murakami T
    2014年01月, Acta Med Kinki Univ, 38(2) (2), 111 - 113

  • Masakatsu Tsurusaki, Masahiko Okada, Hiroyuki Kuroda, Mitsuru Matsuki, Kazunari Ishii, Takamichi Murakami
    Positron emission tomography (PET) is widely available and its application with 2-[F-18] fluoro-2-deoxy-D-glucose (F-18-FDG) in oncology has become one of the standard imaging modalities in diagnosing and staging of tumors, and monitoring the therapeutic efficacy in hepatic malignancies. Recently, investigators have measured glucose utilization in liver tumors using F-18-FDG and positron emission tomography/computer tomography (PET/CT) in order to establish a diagnosis of tumors, assess their biologic characteristics and predict therapeutic effects on hepatic malignancies. The PET/CT with F-18-FDG may further enhance the hepatic malignancy diagnostic algorithm by accurate diagnosis, staging, restaging and evaluating its biological characteristics, which can benefit the patients suffering from primary and metastatic hepatic tumors such as hepatocellular carcinoma (HCC), cholangiocarcinoma (CCC), and metastatic liver tumor.
    SPRINGER JAPAN KK, 2014年01月, JOURNAL OF GASTROENTEROLOGY, 49(1) (1), 46 - 56, 英語
    [査読有り]

  • H. Takahashi, N. Kashiwagi, T. Chikugo, K. Nakanishi, Y. Tomita, T. Murakami
    AIM: To report the magnetic resonance imaging (MRI) and corresponding histopathological features of squamous cell carcinoma (SCC) originating in the parotid gland. MATERIALS AND METHODS: The MRI images of seven patients with histopathologically proven SCC originating in the parotid gland were reviewed retrospectively, with an emphasis on tumour size, shape, contour definition, extraparotid infiltration, signal characteristics, and the presence of central necrosis. These were correlated with the microscopic findings of the surgical specimens. RESULTS: The tumours ranged in size from 3.9-7 cm (mean 4.7 cm). All tumours had an ill-defined margin with extraparotid infiltration, which seemed to reflect the invasive growth of the tumour cells on histopathological examination. The solid portions of the tumours showed predominantly low to intermediate signal intensities on T2-weighted images, which seemed to reflect the high cellularity, intercellular bridges, and/or keratin pearl formation observed at histopathological examination. Five of the seven tumours had central necrosis. CONCLUSION: A relatively large tumour with central necrosis is a useful imaging feature of SCCs originating in the parotid gland, in addition to the well-recognized indicators of parotid malignancy, such as an ill-defined margin, extraparotid infiltration, and low to intermediate signal intensity on T2-weighted images. (C) 2013 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
    W B SAUNDERS CO LTD, 2014年01月, CLINICAL RADIOLOGY, 69(1) (1), 41 - 44, 英語
    研究論文（学術雑誌）

  • Ken Kamata, Masayuki Kitano, Masatoshi Kudo, Hiroki Sakamoto, Kumpei Kadosaka, Takeshi Miyata, Hajime Imai, Kiyoshi Maekawa, Takaaki Chikugo, Masashi Kumano, Tomoko Hyodo, Takamichi Murakami, Yasutaka Chiba, Yoshifumi Takeyama
    Background and study aims: Pancreatic ductal adenocarcinomas (PDAC) sometimes arise in patients with intraductal papillary mucinous neoplasms (IPMNs). This study examined the incidence of PDACs concomitant to or derived from branch duct IPMNs. The usefulness of endoscopic ultrasonography (EUS) relative to other imaging methods for detecting these tumors was also assessed. Patients and methods: This retrospective study used data from clinical records and imaging studies that were collected prospectively. During 2001-2009, 167 consecutive patients with IPMNs underwent EUS, ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI). The 102 patients whose branch duct IPMNs lacked mural nodules/symptoms and thus did not qualify for resection were followed up by semiannual EUS and annual ultrasonography, CT, and MRI. The sensitivity and specificity with which the four modalities detected IPMN-derived and -concomitant PDACs at the first examination and throughout the study period were evaluated. The rate of PDAC development during follow-up was analyzed by the Kaplan-Meier method. Results: A total of 17 IPMN-derived and 11 IPMN-concomitant PDACs were diagnosed at the first examination. Lesions that did not qualify for resection or chemotherapy were followed up for a median of 42 months. Seven IPMN-concomitant PDACs and no IPMN-derived PDACs were detected during follow-up. The 3- and 5-year rates of IPMN-concomitant PDAC development were 4.0% and 8.8%, respectively. At the first examination, EUS was superior to other imaging modalities in terms of IPMN-derived and -concomitant PDAC detection. Throughout the study period, including follow-up, EUS was significantly better at detecting IPMN-concomitant PDACs than the other modalities. Conclusions: IPMN-concomitant PDACs are quite often found at diagnosis and during follow-up.EUS examination of the whole pancreas plays an important role in the management of IPMNs as it allows the early detection of these small invasive carcinomas.
    GEORG THIEME VERLAG KG, 2014年01月, ENDOSCOPY, 46(1) (1), 22 - 29, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masahiro Okada, Takamichi Murakami
    Computed tomography (CT) is essential for the diagnosis of liver tumors. In the CT criteria of hypervascular hepatocellular carcinoma (HCC), the diagnosis is based on hemodynamic findings, such as arterial enhancement, followed by washout in the portal-venous and/or equilibrium phase. In this chapter, typical and atypical findings (HCC mimickers) of HCC on CT and current diagnostic techniques to image HCC were stated.
    Springer US, 2014年01月, Abdomen and Thoracic Imaging: An Engineering and Clinical Perspective, 317 - 346, 英語
    [査読有り]
    論文集(書籍)内論文

  • Ken Kamata, Masayuki Kitano, Masatoshi Kudo, Hiroki Sakamoto, Kumpei Kadosaka, Takeshi Miyata, Hajime Imai, Kiyoshi Maekawa, Takaaki Chikugo, Masashi Kumano, Tomoko Hyodo, Takamichi Murakami, Yasutaka Chiba, Yoshifumi Takeyama
    Georg Thieme Verlag, 2014年, Endoscopy, 46(4) (4), 358, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masashi Kono, Tatsuo Inoue, Masatoshi Kudo, Hirokazu Chishina, Tadaaki Arizumi, Masahiro Takita, Satoshi Kitai, Norihisa Yada, Satoru Hagiwara, Yasunori Minami, Kazuorni Ueshima, Naoshi Nishida, Takamichi Murakami
    Objective:The purpose of this study was to evaluate the risk factors for local recurrence with radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) measuring <= 2 cm. Methods: This study involved 234 patients with 274 HCCs measuring cm who had undergone RFA as the initial treatment. The mean tumor diameter was 1.478 cm. The median follow-up period was 829 days. We evaluated the post-RFA cumulative local recurrence rate and analyzed the risk factors contributing to clinical outcomes. Results: Cumulative local recurrence rates were 9, 19 and 19% at 1,2 and 3 years, respectively. Among the 145 cases with a complete safety margin (SM) after RFA, only 4 developed local tumor recurrence and the cumulative rates of local tumor recurrence at 1, 2 and 3 years were 2, 3 and 3%, respectively. Among the 129 cases with incomplete SM, local tumor recurrence developed in 34 and the cumulative rates of local tumor progression at 1, 2 and 3 years were 14, 36 and 36%, respectively. In multivariate analysis, significant risk factors were tumor location (liver surface), irregular gross type and SM <5 mm. Conclusion: Even with HCC measuring cm, location and gross type of tumor should be carefully evaluated before RFA is performed. (C) 2014 S. Karger AG, Basel
    KARGER, 2014年, DIGESTIVE DISEASES, 32(6) (6), 670 - 677, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Murakami T, Tsurusaki M, Hyodo T, Imai Y
    Informa UK Limited, 2014年, Journal of Hepatocellular Carcinoma, 1, 101 - 108
    [査読有り]
    研究論文（学術雑誌）

  • Takamichi Murakami, Masakatsu Tsurusaki
    Most liver tumors are benign and hypervascular, and it is important to avoid unnecessary interventions for benign lesions. This review describes the typical and atypical imaging features of common hypervascular benign liver tumors and outlines a general approach to distinguishing between benign and malignant hepatic lesions. There are many types of benign liver tumors that need to be differentiated from hepatocellular carcinoma (HCC). Therefore, it is very important to know the imaging characteristics of benign tumors. Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging is helpful in diagnosing hypervascular pseudotumors, focal nodular hyperplasia, and nodular lesions associated with alcohol-induced hepatitis. There are also some hypervascular malignant tumors, such as cholangiocarcinoma, cholangiolocellular carcinoma, mixed type tumors, and metastatic liver tumors, which also required differentiation from HCC. Copyright (C) 2014 S. Karger AG, Basel
    KARGER, 2014年, LIVER CANCER, 3(2) (2), 85 - 96, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yasunori Minami, Yukinobu Yagyu, Takamichi Murakami, Masatoshi Kudo
    Purpose: New tracking navigation imaging software was used to evaluate the usefulness of three dimensional (3D) CT angiography for transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). Materials and Methods: Fifty-two patients with 73 HCCs were enrolled in this study retrospectively. Rotational angiography was performed from the hepatic artery for evaluation of the tumor feeding vessels. Arteries feeding the tumor were traced automatically by adjusting the region of interest around the targeted tumor on axial and coronal images using tracking navigation imaging with 3D cone-beam CT angiography. Results: Using final selective angiographic findings as the gold standard, the detection of feeding vessels was 90.4% (66/73) for tracking navigation imaging and 50.7% (37/73) for celiac trunk angiography. This difference was statistically significant (Wilcoxon rank sum test, p < 0.001). The sensitivity, specificity, positive predictive value, and negative predictive value for the detection of feeding arteries were 97.1% (66/68), 80.0% (4/5), 98.5% (66/67), and 66.7% (4/6), respectively. The kappa coefficient had a value of 0.638 (95% CI: 0.471-0.805), which is considered to indicate a good degree of agreement. With the as-sistance of tracking navigation imaging, the disease control rate of TACE for HCC was 67.3% (35/52) according to the modified Response Evaluation Criteria in Solid Tumors. During follow- up periods of 1-11 months, 10 patients (19.2%) remained cancer-free after TACE. Conclusion: Tracking navigation imaging with 3D cone-beam CT angiography should be useful for TACE in HCC patients with complicated feeding arteries. Copyright (C) 2014 S. Karger AG, Basel
    KARGER, 2014年, LIVER CANCER, 3(1) (1), 53 - 61, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yuko Matsukubo, Nobuo Kashiwagi, Masanobu Uemura, Sachiyo Tatsumi, Hiroto Takahashi, Tomoko Hyodo, Noriyuki Tomiyama, Ryuichiro Ashikaga, Kazunari Ishii, Takamichi Murakami
    Introduction: The aim of this study was to investigate the prevalence of intravertebral pneumatocyst (IVP) of the cervical spine by age group, compared with that of intradiscal vacuum (IDV). Methods: We investigated 500 consecutive patients who underwent cervical computed tomography (CT) from May 2012 to May2013 for various indications. CT datasets were assessed for the presence of IVPs and IDVs with stratification by age. Results: IVPs of the cervical spine were detected in 8 % (7 of 86 subjects) of patients in their forties or below, 30 % (23 of 75) in their fifties, 49 % (67 of 136) in their sixties, 55 % (76 of 137) in their seventies, and 60 % (40 of 66) in their eighties or over. IDVs of the cervical spine were detected in 6, 25, 48, 54, and 57 %, respectively. Coexistence of both phenomena was identified in 4, 17, 33, 40, and 43 %, respectively. Conclusion: IVPs of the cervical spine are a common incidental finding, increasing in prevalence with age and more common than IDV in all age groups. © 2013 Springer-Verlag Berlin Heidelberg.
    11, 2013年11月, Neuroradiology, 55(11) (11), 1341 - 1344, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 細川 知紗, 石井 一成, 木村 裕一, 兵頭 朋子, 坂口 健太, 宇佐美 公男, 細野 眞, 村上 卓道
    (一社)日本核医学会, 2013年11月, 核医学, 50(4) (4), 327 - 327, 日本語

  • Yuki Kagawa, Masahiro Okada, Yukinobu Yagyu, Seishi Kumano, Masayuki Kanematsu, Masayuki Kudo, Takamichi Murakami
    Background: A new multiphasic fast imaging technique, known as volume helical shuttle technique, is a breakthrough for liver imaging that offers new clinical opportunities in dynamic blood flow studies. This technique enables virtually real-time hemodynamics assessment by shuttling the patient cradle back and forth during serial scanning. Purpose: To determine optimal scan timing of hepatic arterial-phase imaging for detecting hypervascular hepatocellular carcinoma (HCC) with maximum tumor-to-liver contrast by volume helical shuttle technique. Material and Methods: One hundred and one hypervascular HCCs in 50 patients were prospectively studied by 64-channel multidetector-row computed tomography (MDCT) with multiphasic fast imaging technique. Contrast medium containing 600 mg iodine per kg body weight was intravenously injected for 30 s. Six seconds after the contrast arrival in the abdominal aorta detected with bolus tracking, serial 12-phase imaging of the whole liver was performed during 24-s breath-holding with multiphasic fast imaging technique during arterial phase. By placing regions of interest in the abdominal aorta, portal vein, liver parenchyma, and hypervascular HCCs on the multiphase images, time-density curves of anatomical regions and HCCs were composed. Timing of maximum tumor-to-liver contrast after the contrast arrival in the abdominal aorta was determined. Results: For the detection of hypervascular HCC at arterial phase, mean time and value of maximum tumor-to-liver contrast after the contrast arrival were 21 s and 38.0 HU, respectively. Conclusion: Optimal delay time for the hepatic arterial-phase imaging maximizing the contrast enhancement of hypervascular HCCs was 21 s after arrival of contrast medium in the abdominal aorta.
    ROYAL SOC MEDICINE PRESS LTD, 2013年10月, ACTA RADIOLOGICA, 54(8) (8), 843 - 850, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Mitsuru Matsuki, Takamichi Murakami, Hiroshi Juri, Shushi Yoshikawa, Yoshifumi Narumi
    Background: While CT is widely used in medical practice, a substantial source of radiation exposure is associated with an increased lifetime risk of cancer. Therefore, concerns to dose reduction in CT examinations are increasing and an iterative reconstruction algorithm, which allow for dose reduction by compensating image noise in the image reconstruction, has been developed. Purpose: To investigate the performance of low-dose abdominal CT using adaptive iterative dose reduction 3D (AIDR 3D) compared to routine-dose CT using filtered back projection (FBP). Material and Methods: Fifty-eight patients underwent both routine-dose CT scans using FBP and low-dose CT scans using AIDR 3D in the abdomen. The image noise levels, signal-to-noise ratios (SNRs), and contrast-to-noise ratios (CNRs) of the aorta, portal vein, liver, and pancreas were measured and compared in both scans. Visual evaluations were performed. The volume CT dose index (CTDIvol) was measured. Results: Image noise levels on low-dose CT images using AIDR 3D were significantly lower than, or not significantly different from, routine-dose CT images using FBP in reviewing the data on the basis of all patients and the three BMI groups. SNRs and CNRs on low-dose CT images using AIDR 3D were significantly higher than, or not significantly different from, routine-dose CT images using FBP in reviewing the data on the basis of all patients and the three BMI groups. In visual evaluation of the images, there were no statistically significant differences between the scans in all organs independently of BMI. The average CTDIvol at routine-dose and low dose CT was 21.4 and 10.8 mGy, respectively. Conclusion: Low-dose abdominal CT using AIDR 3D allows for approximately 50% reduction in radiation dose without a degradation of image quality compared to routine-dose CT using FBP independently of BMI.
    SAGE PUBLICATIONS LTD, 2013年10月, ACTA RADIOLOGICA, 54(8) (8), 869 - 875, 英語
    [査読有り]
    研究論文（学術雑誌）

  • ポリドカノールフォームB-RTOにてショックを来した胃静脈瘤の1例
    鶴崎 正勝, 朝戸 信行, 日高 正二郎, 柳生 行伸, 松木 充, 村上 卓道, 丸山 光也, 神山 和俊, 中村 友則
    (一社)日本インターベンショナルラジオロジー学会, 2013年10月, IVR: Interventional Radiology, 28(4) (4), 490 - 490, 日本語

  • 出血を繰り返した腹壁静脈門脈短絡に対して直接穿刺による硬化療法を施行した1例
    朝戸 信行, 柳生 行伸, 鶴崎 正勝, 日高 正二朗, 任 誠雲, 柏木 伸夫, 松木 充, 足利 竜一朗, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2013年10月, IVR: Interventional Radiology, 28(4) (4), 490 - 490, 日本語

  • Yuki Makino, Yasuharu Imai, Takumi Igura, Masatoshi Hori, Kazuto Fukuda, Yoshiyuki Sawai, Sachiyo Kogita, Hideko Ohama, Yasushi Matsumoto, Masanori Nakahara, Shinichiro Zushi, Masanori Kurokawa, Keisuke Isotani, Manabu Takamura, Norihiko Fujita, Takamichi Murakami
    Aim: To demonstrate the usefulness of the computed tomography (CT) fusion imaging for the evaluation of treatment effect of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). Methods: Eighty-five patients with 94 HCC with complete ablation judged on conventional side-by-side interpretation of pre-RFA and post-RFA CT at the time of RFA were included in this retrospective study. CT data was retrospectively used to create fusion images of pre-RFA and post-RFA CT using automatic rigid registration and manual correction referring to intrahepatic structures and hepatic contours around a tumor. Clinical factors including a minimal ablative margin (MAM) measured on fusion images were examined to prove risk factors for local tumor progression (LTP). Results: LTP was observed in 13 (13.8%) tumors with a median follow up of 21.0 months (range, 2-75). The mean MAM on the fusion image was 1.4 +/- 3.1mm and 23 tumors (24.5%) were judged to be protruding from the ablation zone. Multivariate analysis revealed that protruding from the ablation zone was the only significant factor for LTP (hazard ratio, 7.09; 95% confidential interval, 2.26-22.3; P<0.001). Conclusion: Some HCC were assessed as incomplete ablation on the CT fusion images, although considered completely ablated on side-by-side images at the time of treatment, and incomplete ablation was revealed to be the only independent risk factor for LTP. The CT fusion imaging enables quantitative and accurate evaluation of treatment effect of RFA.
    WILEY-BLACKWELL, 2013年09月, HEPATOLOGY RESEARCH, 43(9) (9), 950 - 958, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tomoaki Ichikawa, Masahiro Okada, Hiroshi Kondo, Hironobu Sou, Takamichi Murakami, Masayuki Kanematsu, Shushi Yoshikawa, Kazuhito Shiosakai, Akiko Hayakawa, Kazuo Awai, Kengo Yoshimitsu, Yasuyuki Yamashita
    Rationale and Objectives: To determine the recommended iodine dose of contrast material (CM) for hepatic arterial-dominant phase (HAP) and hepatic parenchymal phase (HPP) imaging to assess hypervascular hepatocellular carcinoma (HCC). Materials and Methods: This was a prospective study including 348 patients with hypervascular HCC in 77 hospitals as a postmarketing surveillance to investigate the effects of body weight-tailored dose of CM (300 mgl/mL of iohexol) for hepatic multiphasic contrast-enhanced multidetector-row computed tomography imaging. Informed consent was obtained from all patients who were enrolled. The tumor-to-liver contrast (TLC) of HAP images was assessed qualitatively (QL-TLC) and quantitatively (QT-TLC [HU]; computed tomography [CT] value of tumor-CT value of hepatic parenchyma). Minimal and sufficient QT-TLC were defined as CT values corresponding to the median and 75% of QL-TLC assigned with "good," respectively. The recommended iodine dose was estimated by the relationship between iodine dose (mgl/kg) and QT-TLC. Results: There was a good correlation between QL-TLC and QT-TLC. The recommended iodine dose of CM for HAP imaging was considered to be in the range of 567-647 mgl/kg based on minimal (33.7 HU) and sufficient QT-TLC (40.9 HU). Meanwhile, the recommended dose of CM for HPP imaging was 572 mgl/kg as a dose that gives hepatic enhancement more than 50 HU during HPP imaging. Conclusions: The recommended iodine dose of CM for HAP and HPP imaging may be different, being 567-647 mgl/kg and 572 mgl/kg, respectively, in assessing hypervascular HCC.
    ELSEVIER SCIENCE INC, 2013年09月, ACADEMIC RADIOLOGY, 20(9) (9), 1130 - 1136, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 細川 知紗, 石井 一成, 木村 裕一, 兵頭 朋子, 細野 眞, 坂口 健太, 宇佐美 公男, 村上 卓道
    (一社)日本核医学会, 2013年09月, 核医学, 50(3) (3), S182 - S182, 日本語

  • Masatoshi Hori, Tonsok Kim, Hiromitsu Onishi, Izumi Imaoka, Yuki Kagawa, Takamichi Murakami, Atsushi Nakamoto, Takashi Ueguchi, Mitsuaki Tatsumi, Takayuki Enomoto, Tadashi Kimura, Noriyuki Tomiyama
    To prospectively assess the efficacy of 3-T magnetic resonance (MR) imaging using the three-dimensional turbo spin-echo T2-weighted and diffusion-weighted technique (3D-TSE/DW) compared with that of conventional imaging using the two-dimensional turbo spin-echo T2-weighted and dynamic contrast-enhanced technique (2D-TSE/DCE) for the preoperative staging of endometrial cancer, with pathological analysis as the reference standard. Seventy-one women with endometrial cancer underwent MR imaging using 3D-TSE/DW (b = 1,000 s/mm(2)) and 2D-TSE/DCE. Two radiologists independently assessed the two imaging sets. Accuracy, sensitivity, and specificity for staging were analysed with the McNemar test; the areas under the receiver operating characteristic curve (Az) were compared with a univariate z-score test. The results for assessing deep myometrial invasion, accuracy, sensitivity, specificity and Az, respectively, were as follows: 3D-TSE/DW-observer 1, 87 %, 95 %, 85 % and 0.96; observer 2, 92 %, 84 %, 94 % and 0.95; 2D-TSE/DCE-observer 1, 80 %, 79 %, 81 % and 0.89; observer 2, 86 %, 84 %, 87 % and 0.86. Most of the values were higher with 3D-TSE/DW without significant differences (P > 0.12). For assessing cervical stromal invasion, there were no significant differences in those values for both observers (P > 0.6). Accuracy of 3D-TSE/DW was at least equivalent to that of the conventional technique for the preoperative assessment of endometrial cancer.
    SPRINGER, 2013年08月, EUROPEAN RADIOLOGY, 23(8) (8), 2296 - 2305, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Christoph J. Zech, Carlo Bartolozzi, Paulette Bioulac-Sage, Pierce K. Chow, Alejandro Forner, Luigi Grazioli, Alexander Huppertz, Herve Laumonier, Jeong Min Lee, Takamichi Murakami, Jens Ricke, Claude B. Sirlin
    OBJECTIVE. This article reviews topics discussed during the Fifth International Forum for Liver MRI (with a focus on gadoxetic acid-enhanced MRI), which was held in Munich, Germany, in September 2011. CONCLUSION. Growing evidence shows that gadoxetic acid-enhanced MRI has high sensitivity and specificity for diagnosing liver tumors. Hepatobiliary phase imaging adds new information for the characterization of borderline lesions. However, there is a need to develop standardized criteria for interpretation of gadoxetic acid-enhanced MRI in patients with cirrhosis or other risk factors for hepatocellular carcinoma. © American Roentgen Ray Society.
    1, 2013年07月, American Journal of Roentgenology, 201(1) (1), 97 - 107, 英語
    [査読有り]

  • Rieko Okada, Takeshi Okuda, Naoki Nakano, Kazuhiko Nishimatsu, Hiroyuki Fukushima, Minori Onoda, Toshiho Otsuki, Kazunari Ishii, Takamichi Murakami, Amami Kato
    The aim of this study was to identify the location associated with primitive sentence processing. Processing related to generation and comprehension of sentences ("sentence processing") is postulated to be largely divided into syntactic processing (processing related to the formation of sentences and to verb reflection and particles) and verb information (argument structure and thematic role). Numerous lesion studies and functional brain imaging studies on unimpaired individuals have suggested that the left inferior frontal gyrus (IFG) is involved in syntactic processing. In addition, some studies have reported that the area from the left parietal lobe to the posterior superior temporal gyrus is involved in processing information such as argument structure and thematic role. However, studies on sentence processing using functional brain imaging have used complex sentences as tasks, raising the possibility that the results show the demands on not only language processing, but also on working memory. To clarify the brain areas involved in basic sentence processing in human language, there is a need to examine tasks involved in sentence processing that assume more primitive processing with minimal demands on working memory. The present study used sentence-completion tasks in the Japanese language that include basic sentence processing. The results showed activation in the left IFG and left parietal lobe, suggesting that these areas are involved in sentence processing. We then investigated the proportion of patients showing impaired sentence processing from among patients with aphasia and a lesion in the left IFG or from the parietal lobe to the posterior superior temporal gyrus. Four of 5 patients (80%) with lesions mostly in the left IFG showed impaired sentence processing, suggesting that this site plays a critical role in sentence processing. Of the 4 patients with lesions mostly in the area from the left parietal lobe to the posterior superior temporal gyrus, 1 patient (25%) showed impaired sentence processing. Unlike the other 3 subjects, this subject exhibited impaired recalling of verbs. This area is mainly involved in lexical-semantics and the present results suggest that verb information within that field became impaired, in turn causing impaired sentence processing. (C) 2013 Elsevier Ltd. All rights reserved.
    PERGAMON-ELSEVIER SCIENCE LTD, 2013年07月, JOURNAL OF NEUROLINGUISTICS, 26(4) (4), 470 - 478, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Nobuo Kashiwagi, Takamichi Murakami, Katsuyuki Nakanishi, Osamu Maenishi, Kaoru Okajima, Hiroto Takahashi, Mio Sakai, Yasuhiko Tomita, Kyoichi Terao, Noriyuki Tomiyama
    Background: Although pleomorphic adenomas account for over 90% of all benign submandibular gland tumors, the imaging features of submandibular pleomorphic adenomas have not been reported in a large number of cases. Purpose: To assess the conventional magnetic resonance imaging (MRI) findings for predicting the submandibular pleomorphic adenoma. Material and Methods: MR studies of 42 pleomorphic adenomas and 28 other types of tumor were reviewed. MR images were assessed for the presence of hyperintense areas on T2-weighted images (first sign), a well-defined margin (second sign), and presence of crescent-shaped compression of the ipsilateral normal submandibular gland (third sign). Results: For identifying submandibular pleomorphic adenoma, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 97.6%, 50.0%, 74.5%, 93.3%, and 78.6% for the first sign, 95.2%, 46.4% 72.7%, 86.7%, and 75.7% for the second sign, and 23.8%, 100%, 86.7%, 46.7%, and 54.3% for the third sign, respectively. Combining the first and second findings achieved to 85.7% specificity and 90.9% accuracy. Conclusion: Although non-specific, submandibular pleomorphic adenomas usually have hyperintense areas on T2-weighted images and well-defined margins. In addition, crescent-shaped compression of the ipsilateral normal gland seems to represent a highly specific sign.
    2013年06月, Acta Radiologica, 54(5) (5), 511 - 515, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Takashi Katsube, Masahiro Okada, Seishi Kumano, Izumi Imaoka, Yuki Kagawa, Masatoshi Hori, Kazunari Ishii, Noboru Tanigawa, Yasuharu Imai, Masatoshi Kudo, Takamichi Murakami
    2013年06月, European Journal of Radiology, 82(6) (6), 1039, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Spontaneous regression of a cervical desmoid tumor
    Y. Matsukubo, N. Kashiwagi, R. Ashikaga, M. Hosono, T. Murakami, T. Sato, K. Mori, K. Doi
    Although desmoid tumors have benign histological features composed of normal fibroblastic to myofibroblastic proliferations in a fibrous stroma, this tumors often show aggressive clinical behaviors with local invasiveness and a high recurrence rate. Herein, we present a case of spontaneous regression of a cervical desmoid tumor. Serial MRI findings seemed to reflect naturally-occurring histological changes.
    2013年03月, Japanese Journal of Clinical Radiology, 58(3) (3), 459 - 462, 日本語
    研究論文（学術雑誌）

  • Tomoko Hyodo, Takamichi Murakami, Yasuharu Imai, Masahiro Okada, Masatoshi Hori, Yuki Kagawa, Sachiyo Kogita, Seishi Kumano, Masatoshi Kudo, Teruhito Mochizuki
    Purpose: To identify patient characteristics and magnetic resonance (MR) imaging findings associated with subsequent hypervascularization in hypovascular nodules that show hypointensity on hepatobiliary phase gadoxetic acid-enhanced MR images in patients with chronic liver diseases. Materials and Methods: Institutional review board approval was obtained, and informed consent was waived. At multiple follow-up gadoxetic acid-enhanced MR imaging examinations of 68 patients, 160 hypovascular nodules were retrospectively reviewed. A Cox regression model for hypervascularization was developed to explore the association of baseline characteristics, including patient factors (Child-Pugh classification, etiology of liver disease, history of local therapy for hepatocellular carcinoma [HCC], and coexistence of hypervascular HCC) and MR imaging findings (fat content, signal intensity on T2-weighted images, and nodule size). In addition, the growth rate was calculated as the reciprocal of tumor volume doubling time to investigate its relationship with subsequent hypervascularization by using receiver operating characteristic and Kaplan-Meier analyses. Results: The prevalence of subsequent hypervascularization was 31% (50 of 160 nodules). Independent Cox multivariable predictors of increased risk of hypervascularization were hyperintensity on T2-weighted images (hazard ratio [HR] = 8.7; 95% confidence interval [CI]: 3.6, 20.8), previous local therapy for hypervascular HCC (HR = 5.0; 95% CI: 1.8, 13.6), Child-Pugh B cirrhosis (HR = 3.6; 95% CI: 1.4, 9.5) and coexistence of hypervascular HCC (HR = 2.0; 95% CI: 1.0, 3.8). The mean growth rate was significantly higher in nodules that showed subsequent hypervascularization than in those without hypervascularization. Kaplan-Meier analysis based on the receiver operating characteristic cutoff level (1.8 x 10(-3)/day [tumor volume doubling time, 542 days]) showed that nodules with a higher growth rate had a significantly higher incidence of hypervascularization (P = 5.2 x 10(-8), log-rank test). Conclusion: Hyperintensity on T2-weighted images is an independent and strong risk factor at baseline for subsequent hypervascularization in hypovascular nodules in patients with chronic liver disease. Tumor volume doubling time of less than 542 days was associated with a high rate of subsequent hypervascularization. (C)RSNA, 2013
    RADIOLOGICAL SOC NORTH AMERICA, 2013年02月, RADIOLOGY, 266(2) (2), 480 - 490, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 大腿四頭筋血腫の経過で隣接骨の皮質過形成をきたした1例
    森田 敬裕, 柏木 伸夫, 兵頭 朋子, 柳生 行伸, 小塚 健倫, 熊野 正士, 今岡 いずみ, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, 2013年02月, Japanese Journal of Radiology, 31(Suppl.I) (Suppl.I), 47 - 47, 日本語

  • 外傷性神経腫の1例
    藤谷 哲也, 柏木 伸夫, 今岡 いずみ, 熊野 正士, 石井 一成, 足利 竜一朗, 村上 卓道, 前西 修, 楠原 廣久, 磯貝 典孝
    (公社)日本医学放射線学会, 2013年02月, Japanese Journal of Radiology, 31(Suppl.I) (Suppl.I), 53 - 53, 日本語

  • Dual-energy CTによる肝脂肪定量 ファントム実験によるsingle-energy CTおよびMRSとの比較
    兵頭 朋子, 岡田 真広, 工藤 正幸, 鶴崎 正勝, 足利 竜一朗, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, 2013年02月, 日本医学放射線学会学術集会抄録集, 72回, S251 - S251, 日本語

  • 3次元ボリュームCT画像データと肝自動抽出ソフトウェアを用いた肝容積測定
    堀 雅敏, 金 東石, 大西 裕満, 中本 篤, 富山 憲幸, 小林 省吾, 丸橋 繁, 永野 浩昭, 村上 卓道
    (公社)日本医学放射線学会, 2013年02月, 日本医学放射線学会学術集会抄録集, 72回, S285 - S285, 日本語
    [査読有り]

  • Yuki Makino, Yasuharu Imai, Hideko Ohama, Takumi Igura, Sachiyo Kogita, Yoshiyuki Sawai, Kazuto Fukuda, Manabu Takamura, Hiroshi Ohashi, Takamichi Murakami
    Objectives: To investigate the usefulness of the ultrasonography (US) fusion imaging system for radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). Methods: Since the US fusion imaging system became available in 2010, we have conducted RFA with this system in all cases. The characteristics of 75 patients with 120 HCCs and 89 patients with 123 HCCs who underwent RFA before the introduction of this system (period A) and after it (period B), respectively, were retrospectively compared. Results: Significant difference in the characteristics of the patients and HCCs between the two periods was found only in the proportion of HCCs with poor conspicuity on grayscale US treated with RFA (1.7%, 2/120 for period A vs. 15.4%, 19/123 for period B, p < 0.01). Among the 19 HCCs with poor conspicuity on grayscale US for period B, 5 and 9 HCCs were identified on grayscale US and contrast-enhanced US, respectively, by the use of the US fusion imaging system, whereas the 5 remaining undetectable HCCs were treated by using the system in conjunction with reference images displayed side-by-side with grayscale US. Conclusion: Since the introduction of the US fusion imaging system, it has become possible to perform RFA for HCCs with poor conspicuity on grayscale US. Copyright (C) 2013 S. Karger AG, Basel
    KARGER, 2013年, ONCOLOGY, 84, 44 - 50, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masahiro Okada, Hiroshi Kondo, Hironobu Sou, Takamichi Murakami, Masayuki Kanematsu, Tomoaki Ichikawa, Shushi Yoshikawa, Kazuhito Shiosakai, Akiko Hayakawa, Kazuo Awai, Kengo Yoshimitsu, Yasuyuki Yamashita
    Purpose: To investigate four different contrast protocols to detect hypervascular hepatocellular carcinoma (HCC) most adaptable for patients at any body weight (BW) in clinical practice. Materials and methods: A post-marketing surveillance of liver dynamic CT was prospectively performed by four different protocols in 415 patients: Protocol-A, BW-tailored dose of contrast media (CM: iohexol 300 mgI/mL), fixed injection duration (30s), fixed scan timing at arterial phase (AP); Protocol-B, BW-tailored dose of CM, fixed injection duration (30s), by bolus tracking; Protocol-C, BW-tailored dose of CM, fixed injection flow rate, by bolus tracking; Protocol-D, 100 mL constant of CM at any BW, fixed scan timing. Scan timing and tumor conspicuity at AP was scored qualitatively. The quantitative CT values of aorta and tumor liver contrast (TLC) were obtained. Results: The qualitative rate assessed "good" as scan timing of AP in Protocol-C was significantly lower than those in Protocols A and D (difference: 16.6%, 17.4%, P = 0.0069, P = 0.0140, respectively). Scatter plot of Protocol-D (R-2 = 0.1283) at AP showed significant inverse relationship between TLC and BW (P = 0.0053), although not significant in Protocols A, B, C. Conclusion: In patients with higher BW, protocols of BW-tailored dose of CM and/or fixed injection duration have no dependence on BW to diagnose hypervascular HCCs.
    SPRINGER INTERNATIONAL PUBLISHING AG, 2013年, SPRINGERPLUS, 2(2) (2), 367 - 378, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tatsuo Inoue, Tomoko Hyodo, Takamichi Murakami, Yukihisa Takayama, Akihiro Nishie, Atsushi Higaki, Keiko Korenaga, Azusa Sakamoto, Yukio Osaki, Hiroshi Aikata, Kazuaki Chayama, Takeshi Suda, Toru Takano, Kennichi Miyoshi, Masahiko Koda, Kazushi Numata, Hironori Tanaka, Hiroko Iijima, Hironori Ochi, Masashi Hirooka, Yasuharu Imai, Masatoshi Kudo
    Objective: We aimed to investigate the natural outcome of nonhypervascular lesions detected in the hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI by performing a longitudinal study retrospectively enrolled in a nationwide manner. Methods: Between February 2008 and March 2011, 224 patients with 504 nodules that were diagnosed as nonhypervascular by imaging were recruited from institutions that participated in the present study. We examined the natural outcome of nonhypervascular lesions and evaluated the risk factors. Results: Of the 504 nodules, 173 (34.3%) showed hypervascular transformation. The overall cumulative incidence of hypervascular transformation was 14.9% at 12 months and 45.8% at 24 months. Multivariate analysis using the Cox regression model revealed previous treatment history for hepatocellular carcinoma (HCC relative risk = 1.498 p = 0.036, 95% CI 1.03-2.19) and hyperintensity on T2-weighted images (relative risk = 1.724 p = 0.015, 95% CI 1.11-2.67) were identified as independent factors for hypervascular transformation. Conclusions: Patients who have a previous treatment history for HCC and with hypointense nodules showing hyperintensity on T2-weighted images need careful follow-up because of the high incidence of hypervascular transformation.
    S. Karger AG, 2013年, Digestive Diseases, 31(5-6) (5-6), 472 - 479, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yuki Makino, Yasuharu Imai, Takumi Igura, Sachiyo Kogita, Yoshiyuki Sawai, Kazuto Fukuda, Masatoshi Hori, Masatoshi Kudo, Takamichi Murakami
    Objectives: We developed a novel technique of the extracted-overlay function in CT/MR-ultrasonography (US) fusion imaging for radiofrequency ablation (RFA), in which only a tumor extracted from CT/MR images with a virtual ablative margin of arbitrary thickness is overlaid on US. The usefulness of this function is investigated in this preliminary report. Methods: The volume data of the extracted tumor with a virtual ablative margin were created on an image-processing workstation, and transported into a US unit equipped with a CT/MR-US fusion imaging system. After the positional registration of US and transported images, the extracted tumor with an ablative margin could be overlaid on US. In RFA, using this function, an electrode was inserted targeting the overlaid tumor with an ablative safety margin of 5 mm on US, and the treatment effect was evaluated by dynamic CT. Treatment results of 23 consecutive hepatocellular carcinomas (HCCs) that underwent RFA using this function were retrospectively analyzed. Results: Complete tumor ablation was achieved in 22 (95.7%) and 1 (4.3%) HCCs in 1 and 2 treatment sessions, respectively. Conclusions: Due to the visualization of an extracted tumor with an ablative safety margin on a US image, even during and after ablation, this function is useful for treatment planning and guidance of RFA. (C) 2013 S. Karger AG, Basel
    KARGER, 2013年, DIGESTIVE DISEASES, 31(5-6) (5-6), 485 - 489, 英語
    [査読有り]
    研究論文（学術雑誌）

  • ダイナミックマルチスライスCTにおける多血性肝細胞癌検出に最適な造影剤量の検討
    藤谷哲也, 熊野正士, 村上卓道
    2012年11月, 近畿大学医学雑誌, 37(3,4) (3,4), 155 - 162

  • The Usefullness of Conventional MR imaging in Establishing the Daiagnosis of Submandibular Pleomorphic Adenoma.
    柏木伸夫, 高橋洋人, 前西 修, 岡嶋 馨, 村上卓道, 石井一成, 中西克之
    2012年11月

  • Seishi Kumano, Masahiro Okada, Taro Shimono, Masatomo Kuwabara, Yukinobu Yagyu, Izumi Imaoka, Ryuichiro Ashikaga, Kazunari Ishii, Takamichi Murakami
    Purpose: The purpose of this study was to evaluate the accuracy of T-staging of gastric cancer by air-filling multidetector-row CT (air-MDCT) compared with water-filling MDCT (hydro-MDCT). Materials and methods: One hundred fifteen patients with histologically diagnosed gastric cancer were included in this study. Fifty-eight patients underwent air-MDCT, and the remaining 57 had hydro-MDCT using a 64-channel scanner. Based on the volumetric data of contrast-enhanced MDCT obtained about 75 s after intravenously injecting 525 mg iodine per kilogram patients weight (525 mgI/kg) nonionic contrast material at the rate of 2 ml/s, oblique coronal and oblique sagittal multi-planar reformatted images perpendicular to the stomach wall, including the tumor, were reconstructed on a workstation. Mural invasion of gastric cancer into the gastric wall, as visualized by CT, was classified according to the TNM classification, and the results of T-staging by MDCT were compared with those by pathologic analysis after surgery. Results: Correct assessment of T-staging by air-CT was achieved in 48 of 58 patients (83%), and that by hydro-MDCT was 49 of 57 patients (86%). The sensitivity, specificity, and accuracy of the technique in determining the invasion of serosa were 88%, 93%, and 91% for air-CT and 83%, 95%, and 91% for hydro-CT. There were no significant differences between hydro-MDCT and air-MDCT in sensitivity (P = 0.73), specificity (P = 0.71) and accuracy (P = 0.98). Conclusion: Air-MDCT is a very valuable tool in T-staging of gastric cancer as well as hydro-MDCT. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
    ELSEVIER IRELAND LTD, 2012年11月, EUROPEAN JOURNAL OF RADIOLOGY, 81(11) (11), 2953 - 2960, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tetsuya Fujigai, Seishi Kumano, Masahiro Okada, Tomoko Hyodo, Izumi Imaoka, Yukinobu Yagyu, Ryuichiro Ashikaga, Kazunari Ishii, Takamichi Murakami
    Purpose: The purpose of this study is to prospectively investigate the optimal dose of contrast medium for the depiction of hypervascular hepatocellular carcinoma (HCC) during the hepatic arterial phase (HAP), portal venous phase (PVP) and delayed phase (DP) of dynamic MDCT. Materials and methods: The study included 128 patients, out of these patients, 36 patients were found to have 56 hypervascular HCCs. Sixty-three patients were assigned to receive a dose of 525 mgI/kg with protocol A, and 62 received a dose of 630 mgI/kg with protocol B. Measurements of the attenuation values of the abdominal aorta, portal vein, hepatic vein, hepatic parenchyma and HCC during the HAP, PVP and DP were taken. Tumor-liver contrast (TLC) was calculated from the attenuation value of the hepatic parenchyma and HCC. Results: The aortic attenuation value with protocol B (351, 166, and 132 HU) was significantly higher than that with protocol A (313, 153, and 120 HU) during all the phases, (P < 0.01 for all phases). The hepatic enhancement from unenhanced baseline with protocol B (25.2, 63.6, 50.6 HU) was significantly higher than that with protocol A (20.2, 55.1 and 43.0 HU) during all the phases, (P < 0.01 for all phases). The TLC with protocol B (37.4, -11.8 and -13.6 HU) was significantly higher than that with protocol A (28.0, -9.8 and -12.1 HU) during HAP (P = 0.042). Conclusion: The administration of 630 mgI/kg of body weight depicts hypervascular HCC more clearly during HAP and shows sufficient hepatic enhancement of 50 HU during DP. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
    ELSEVIER IRELAND LTD, 2012年11月, EUROPEAN JOURNAL OF RADIOLOGY, 81(11) (11), 2978 - 2983, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 【年齢別特徴をふまえた脳神経画像診断-小児から成人まで-】感染症
    松木 充, 藤谷 哲也, 松久保 祐子, 高橋 洋人, 柏木 伸夫, 足利 竜一郎, 石井 一成, 村上 卓道
    (株)学研メディカル秀潤社, 2012年10月, 画像診断, 32(13) (13), 1252 - 1267, 日本語

  • 脳血管性認知症のcilostazol投与前後における脳血流変化の検討
    花田 一志, 細野 眞, 辻井 農亜, 船津 浩二, 明石 浩幸, 原田 毅, 三川 和歌子, 池田 真優子, 白川 治, 村上 卓道
    日本臨床精神神経薬理学会・日本神経精神薬理学会, 2012年10月, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 22回・42回, 146 - 146, 日本語
    [査読有り]

  • Tatsuo Inoue, Masatoshi Kudo, Mina Komuta, Sosuke Hayaishi, Taisuke Ueda, Masahiro Takita, Satoshi Kitai, Kinuyo Hatanaka, Norihisa Yada, Satoru Hagiwara, Hobyung Chung, Toshiharu Sakurai, Kazuomi Ueshima, Michiie Sakamoto, Osamu Maenishi, Tomoko Hyodo, Masahiro Okada, Seishi Kumano, Takamichi Murakami
    We aimed to evaluate gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for the detection of hepatocellular carcinomas (HCCs) and dysplastic nodules (DNs) compared with dynamic multi-detector row computed tomography (MDCT), and to discriminate between HCCs and DNs. Eighty-six nodules diagnosed as HCC or DNs were retrospectively investigated. Gd-EOB-DTPA-enhanced MRI and dynamic MDCT were compared with respect to their diagnostic ability for hypervascular HCCs and detection sensitivity for hypovascular tumors. The ability of hepatobiliary images of Gd-EOB-DTPA-enhanced MRI to discriminate between these nodules was assessed. We also calculated the EOB enhancement ratio of the tumors. For hypervascular HCCs, the diagnostic ability of Gd-EOB-DTPA-enhanced MRI was significantly higher than that of MDCT for tumors less than 2 cm (p = 0.048). There was no difference in the detection of hypervascular HCCs between hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI (43/45: 96%) and dynamic MDCT (40/45: 89%), whereas the detection sensitivity of hypovascular tumors by Gd-EOB-DTPA-enhanced MRI was significantly higher than that by dynamic MDCT (39/41: 95% vs. 25/41: 61%, p = 0.001). EOB enhancement ratios were decreased in parallel with the degree of differentiation in DNs and HCCs, although there was no difference between DNs and hypovascular well-differentiated HCCs. The diagnostic ability of Gd-EOB-DTPA-enhanced MRI for hypervascular HCCs less than 2 cm was significantly higher than that of MDCT. For hypovascular tumors, the detection sensitivity of hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI was significantly higher than that of dynamic Gd-EOB-DTPA-enhanced MRI and dynamic MDCT. It was difficult to distinguish between DNs and hypovascular well-differentiated HCCs based on the EOB enhancement ratio.
    SPRINGER JAPAN KK, 2012年09月, JOURNAL OF GASTROENTEROLOGY, 47(9) (9), 1036 - 1047, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 兵頭 朋子, 岡田 真広, 矢田 典久, 前西 修, 香川 祐毅, 任 誠雲, 柏木 伸夫, 柳生 行伸, 今岡 いずみ, 松木 充, 足利 竜一朗, 石井 一成, 工藤 正俊, 村上 卓道
    近畿大学医学会, 2012年09月, 近畿大学医学雑誌, 37(3-4) (3-4), 18A - 18A, 日本語

  • T. Hyodo, S. Kumano, F. Kushihata, M. Okada, M. Hirata, T. Tsuda, Y. Takada, T. Mochizuki, T. Murakami
    Recent developments in imaging technology have enabled CT and MR cholangiopancreatography (MRCP) to provide minimally invasive alternatives to endoscopic retrograde cholangiopancreatography for the pre- and post-operative assessment of biliary disease. This article describes anatomical variants of the biliary tree with surgical significance, followed by comparison of CT and MR cholangiographies. Drip infusion cholangiography with CT (DIC-CT) enables high-resolution three-dimensional anatomical representation of very small bile ducts (e. g. aberrant branches, the caudate branch and the cystic duct), which are potential causes of surgical complications. The disadvantages of DIC-CT include the possibility of adverse reactions to biliary contrast media and insufficient depiction of bile ducts caused by liver dysfunction or obstructive jaundice. Conventional MRCP is a standard, non-invasive method for evaluating the biliary tree. MRCP provides useful information, especially regarding the extrahepatic bile ducts and dilated intrahepatic bile ducts. Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced MRCP may facilitate the evaluation of biliary structure and excretory function. Understanding the characteristics of each type of cholangiography is important to ensure sufficient perioperative evaluation of the biliary system.
    BRITISH INST RADIOLOGY, 2012年07月, BRITISH JOURNAL OF RADIOLOGY, 85(1015) (1015), 887 - 896, 英語
    [査読有り]

  • Takashi Katsube, Masahiro Okada, Seishi Kumano, Izumi Imaoka, Yuki Kagawa, Masatoshi Hori, Kazunari Ishii, Noboru Tanigawa, Yasuharu Imai, Masatoshi Kudo, Takamichi Murakami
    Purpose: To investigate the usefulness of T2* mapping of liver on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI for estimating liver function. Materials and methods: 33 patients were classified into 3 groups as follows: normal liver function (NLF) (n = 7); mild liver damage (MLD) (n = 16) with Child-Pugh A; severe liver damage (SLD) (n = 10) with Child-Pugh B. T2*-weighted gradient-echo (T2* W-GRE) and T1-weighted gradient-echo (T1W-GRE) images were obtained before and after Gd-EOB-DTPA administration (3, 8, 13, and 18 min; 5, 10,15, and 20 min; respectively). T2* mapping of liver was calculated from T2* W-GRE, then T2* values of liver and T2* reduction rates of T2* value between pre-and post-contrast enhancement were measured. The increase rates of liver-to-muscle signal intensity (LMS) ratio on T1W-GRE between pre-and post-contrast enhancement were calculated. Results: T2* values on pre-and post-contrast showed no significant differences among three groups. Significant differences in T2* reduction rates were found among groups, and those of LCB were lower than those of other groups (NLF: MLD: SLD, 3.8: 6.0: 0.6% at 3 min, 8.2: 10.3: 1.0% at 8 min, 10.7: 11.5: 1.2% at 13 min, and 16.1: 13.2: 3.5% at 18 min, respectively) (P < 0.05). Significant differences in increase rates of LMS ratio on T1W-GRE were identified (NLF: MLD: SLD, 1.53: 1.46: 1.35 at 5 min, 1.68: 1.64: 1.37 at 10 min, 1.79: 1.76: 1.44 at 15 min, and 1.89: 1.78: 1.49 at 20 min, respectively). Conclusion: T2* reduction rate and increase rate of LMS ratio on T1W-GRE may allow us estimation of liver function according to Child-Pugh score. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
    ELSEVIER IRELAND LTD, 2012年07月, EUROPEAN JOURNAL OF RADIOLOGY, 81(7) (7), 1460 - 1464, 英語
    [査読有り]
    研究論文（学術雑誌）

  • N. Kashiwagi, K. Dote, K. Kawano, Y. Tomita, T. Murakami, K. Nakanishi, Y. Araki, K. Mori, N. Tomiyama
    Objective: The aim of this study was to correlate the MRI appearance and pathological findings in each grade of the mucoepidermoid carcinoma (MEC) of the parotid gland. Methods: We reviewed surgically proven MECs of parotid glands in 20 patients. Pathologically, 5 tumours were high-grade, 3 were intermediate and 12 were low-grade. MR images were evaluated with emphasis on signal intensities on T-2 weighted images, margin characteristics and lymph node metastasis, correlating these with pathological features. Results: Among the high-grade MECs, four out of five tumours showed inhomogeneous low to intermediate signal intensity on T-2 weighted images, reflecting high cellularity. All tumours had an ill-defined margin, reflecting invasive tumour growth. Among the intermediate-grade MECs, all three tumours showed intermediate signal intensity on T-2 weighted images and two tumours had an ill-defined margin. Among the low-grade MECs, 11 of the 12 tumours had a hyperintense area on T-2 weighted images because of the existence of abundant mucin secreting cells. Seven tumours had an ill-defined margin, reflecting peritumoural inflammatory changes rather than invasive tumour growth. Lymph node metastasis was seen in three high-grade MECs. Conclusion: MECs of the parotid gland show variable MRI findings reflecting their histological nature, which seems to have certain tendencies depending on the tumour grade.
    BRITISH INST RADIOLOGY, 2012年06月, BRITISH JOURNAL OF RADIOLOGY, 85(1014) (1014), 709 - 713, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masahiro Okada, Kazunari Ishii, Kazushi Numata, Tomoko Hyodo, Seishi Kumano, Masayuki Kitano, Masatoshi Kudo, Takamichi Murakami
    BACKGROUND: Excretion of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) in the bile may be related to liver function, because of elimination from the liver after preferential uptake by hepatocytes. The purpose of this study was to investigate the relation between liver and biliary enhancement in patients with or without liver dysfunction, and to compare the tumor-to-liver contrast in these patients. METHODS: Forty patients [group 1: normal liver and Child-Pugh class A in 20 patients, group 2: Child-Pugh class B in 18 patients and Child-Pugh C in 2] were evaluated. All patients underwent MR imaging of the liver using a 1.5-Tesla system. T1-weighted 3D images were obtained at 5, 10, 15 and 20 minutes after Gd-EOB-DTPA injection. The relation between group 3 (total bilirubin <1.8 mg/dL) and group 4 (total bilirubin >= 1.8 mg/dL) was investigated at 20 minutes. Liver and biliary signals were measured, and compared between groups 1 and 2 or groups 3 and 4. Tumor-to-liver ratio was also evaluated between groups 1 and 2. Scheffes post-hoc test after two-way repeated-measures ANOVA and Pearson's correlation test were used for statistical analysis. RESULTS: Liver enhancement showed significant difference at all time points between groups 1 and 2. Biliary enhancement did not show a significant difference between groups 1 and 2 at 5 minutes, but did at 10, 15 and 20 minutes. At 20 minutes, significant differences between groups 3 and 4 were seen for liver and biliary enhancement. At all time points, liver enhancement correlated with biliary enhancement in both groups. At 5 minutes and 20 minutes, statistical differences between groups 1 and 2 were seen for tumor-to-liver ratio. CONCLUSIONS: The degree of biliary enhancement has a close correlation to that of liver enhancement. It is especially important that insufficient liver enhancement causes lower tumor-to-liver contrast in the hepatobiliary phase of Gd-EOB-DTPA.
    ZHEJIANG UNIV SCH MEDICINE, 2012年06月, HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, 11(3) (3), 307 - 313, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Izumi Imaoka, Takayuki Nakatsuka, Tetsuro Araki, Takashi Katsube, Masahiro Okada, Seishi Kumano, Kazunari Ishii, Ryuichiro Ashikaga, Tomoyuki Okuaki, Marc Van Cauteren, Takamichi Murakami
    Background: Previous literature demonstrated that the T2* value of the uterine junctional zone was lower than that of peripheral myometrium by using BOLD MR imaging. We expect T2* mapping image may add more information to T2-weighted images of the uterine myometrium. Purpose: To evaluate whether T2* mapping software would reproduce the result of previous report, and to apply the software to benign uterine diseases. Material and Methods: Five healthy volunteers and 19 patients clinically suspected of having benign pelvic disease were imaged using a 1.5T MR system. All women were of reproductive age, and all provided informed consent. Sagittal T2* images using a multishot EPI sequence were obtained. T2* values were calculated and color T2* maps reconstructed using a T2* fitting tool. Results: The uterine zones could be identified in all 24 examinations on the T2* maps. In addition, a thin "4th zone" was seen between the endometrium and the JZ (junctional zone) in 19 of 24 examinations. The T2* value of JZ was significantly lower than that of peripheral myometrium (PM) (P < 0.001). No significant difference in the T2* value of the JZ or of PM was noted between normal uterus and uterus with leiomyomas and/or adenomyosis. Conclusion: A quantitative T2* map can easily be obtained using the PRIDE software T2* fitting tool, and the software reproduces the result from previous report. T2* value of the junctional zone was lower than that of peripheral myometrium regardless of having benign myometrial diseases.
    ROYAL SOC MEDICINE PRESS LTD, 2012年05月, ACTA RADIOLOGICA, 53(4) (4), 473 - 477, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Detachable coilのアンラベルに対してgooseneck snareでコイル除去を行った1例
    柳生 行伸, 任 誠雲, 朝戸 信行, 香川 祐毅, 森田 敬裕, 日高 正二朗, 柏木 伸夫, 足利 竜一朗, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2012年05月, IVR: Interventional Radiology, 27(2) (2), 214 - 214, 日本語

  • Hiromitsu Onishi, Tonsok Kim, Yasuharu Imai, Masatoshi Hori, Hiroaki Nagano, Yasuhiro Nakaya, Takahiro Tsuboyama, Atsushi Nakamoto, Mitsuaki Tatsumi, Seishi Kumano, Masahiro Okada, Manabu Takamura, Kenichi Wakasa, Noriyuki Tomiyama, Takamichi Murakami
    To retrospectively compare the accuracy of detection of hypervascular hepatocellular carcinoma (HCC) by multiphasic multidetector CT and by gadoxetate disodium-enhanced MR imaging. After ethical approval, we analysed a total of 73 hypervascular HCC lesions from 31 patients suspected of having HCC, who underwent both gadoxetate disodium-enhanced MR imaging and multiphasic multidetector CT. Five blinded observers independently reviewed CT images, as well as dynamic MR images alone and combined with hepatobiliary phase MR images. Diagnostic accuracy (Az values), sensitivities and positive predictive values were compared by using the Scheffe post hoc test. The mean Az value for dynamic and hepatobiliary phase MR combined (0.81) or dynamic MR images alone (0.78) was significantly higher than that for CT images (0.67, P < 0.001, 0.005, respectively). The mean sensitivity of the combined MR images (0.67) was significantly higher than that of dynamic MR alone (0.52, P < 0.05) or CT images (0.44, P < 0.05). The mean positive predictive values were 0.96, 0.95 and 0.94, for CT, dynamic MR alone and combined MR images, respectively. Compared with multiphasic multidetector CT, gadoxetate disodium-enhanced MR imaging combining dynamic and hepatobiliary phase images results in significantly improved sensitivity and diagnostic accuracy for detection of hypervascular HCC. aEuro cent Gadoxetate disodium is a new liver-specific MR imaging contrast agent. Gadoxetate disodium-enhanced MRI helps the assessment of patients with liver disease. aEuro cent It showed high diagnostic accuracy for the detection of hepatocellular carcinoma.
    SPRINGER, 2012年04月, EUROPEAN RADIOLOGY, 22(4) (4), 845 - 854, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Kazunari Ishii, Kohei Hanaoka, Masahiro Okada, Seishi Kumano, Yoshihiro Komeya, Norio Tsuchiya, Makoto Hosono, Takamichi Murakami
    The aim of this study was to elucidate the regional differences between brain perfusion single photon emission computed tomography (SPECT) images reconstructed with a uniform attenuation correction using Chang's method (AC-Chang) and a non-uniform attenuation correction with CT using SPECT/CT (AC-CT). SPECT images of a phantom with and without head holder were obtained, and reconstructed images of AC-Chang and AC-CT were compared. Twenty-eight consecutive patients with brain disease examined by SPECT/CT brain perfusion imaging were selected, and images were reconstructed with AC-Chang and AC-CT. The AC-Chang and AC-CT reconstructed images were then compared by voxel-based analysis using three-dimensional stereotactic surface projections. Counts in the frontal area of the AC-Chang phantom image with head holder were higher than those in the posterior area. Counts in the frontal area of the AC-Chang clinical images were significantly higher than those in the AC-CT images, while the counts in the margin of the frontal lobe and posterior margin of the parietal, occipital cortices and cerebellum of the AC-Chang images were significantly lower. Relative frontal perfusion was 5.0% higher and relative cerebellar perfusion was 4.6% lower in the AC-Chang images relative to the AC-CT images, on average. We demonstrated the frontal dominant hyper-perfusion and parieto-occipital and cerebellar hypo-perfusion in brain SPECT images reconstructed with AC-Chang compared to those reconstructed with AC-CT. We suggest that to obtain an accurate attenuation-corrected brain perfusion SPECT image, attenuation correction by Chang's method is inadequate.
    SPRINGER, 2012年04月, ANNALS OF NUCLEAR MEDICINE, 26(3) (3), 241 - 247, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yoshifumi Nakauchi, Yoshitaka Iwanaga, Shinichiro Ikuta, Masayuki Kudo, Kazuhiro Kobuke, Takamichi Murakami, Shunichi Miyazaki
    Objective To assess the feasibility of quantitative myocardial perfusion imaging (MPI) in acute myocardial infarction (AMI), using multi-row detector CT (MDCT) with a model-based deconvolution method. Design, setting, patients and interventions Fifteen normal subjects with normal coronary arteries and 26 patients with AMI after reperfusion therapy underwent MPI with MDCT. Perfusion parameters: tissue blood flow (TBF), tissue blood volume (TBV) and mean transit time (MTT) were obtained and compared with clinical parameters, angiography and single-photon emission CT (SPECT) data. Furthermore, the MPI data were compared with data from myocardial magnetic resonance (MR) in 10 subjects. Results The TBF and TBV of infarcted myocardium were significantly lower than those of non-infarcted areas (TBF, 51.96 +/- 19.42 vs 108.84 +/- 13.29 ml/100 g/min, p<0.01; TBV, 4.47 +/- 2.23 vs 9.79 +/- 2.58 ml/100 g, p<0.01). The MTT of infarcted areas did not differ from that of non-infarcted areas. The defect areas on TBV colour maps were significantly associated with peak creatine kinase level, QRS score and SPECT defect score. The ratio of TBF or TBV in the epicardial to endocardial side was significantly higher in infarct myocardium with good collateral circulation than in myocardium with poor/no collateral circulation (p<0.01 for both). The TBF measurements with CT- and MR-MPI were in good agreement by linear regression analysis (R=0.55, p<0.01). Conclusions This study demonstrated that MDCT perfusion imaging with deconvolution analysis could quantitatively detect myocardial perfusion abnormalities in patients with AMI and may provide the basis for the non-invasive and quantitative assessment of myocardial infarction.
    B M J PUBLISHING GROUP, 2012年04月, HEART, 98(7) (7), 566 - 572, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Nobuo Kashiwagi, Takamichi Murakami, Takaaki Chikugo, Yasuhiko Tomita, Kiyoshi Kawano, Katsuyuki Nakanishi, Kazunori Mori, Noriyuki Tomiyama
    Background: Carcinoma ex pleomorphic adenoma (CXPA) is a rare aggressive epithelial malignancy arising from a primary or recurrent benign mixed tumor. Only a few case reports describing the radiologic features of CXPA have been published. Purpose: To describe and characterize the magnetic resonance (MR) imaging findings of CXPA in the parotid gland and correlate them with pathologic findings. Material and Methods: The MR images of surgically proven CXPA in the parotid gland of five men and five women ranging in age from 28 to 75 years (mean 52 years) were retrospectively reviewed. All MR images were evaluated with emphasis on the size, margin characteristics, extraparotid infiltration, the presence of an encapsulated component, and signal intensity on T2-weighted or short-inversion-time inversion recovery (STIR) images. Results: The average maximal diameter was 4.3 cm. All 10 tumors had ill-defined boundaries, and seven tumors showed extraparotid infiltration, reflecting invasive growth of the malignant component identified on histological examination. Eight tumors had a round encapsulated component and seven of those signal intensities were a mixture of hypo- and hyperintensity on T2-weighted or STIR images. Histological correlation of these components revealed fibrously encapsulated tumors containing hyalinization and myxoid tissue, suggesting degenerated pleomorphic adenoma. Invasive malignant components had non-specific and various signal intensities. Conclusion: An invasive parotid mass co-existing with a round encapsulated component is suggestive of carcinoma ex pleomorphic adenoma.
    ROYAL SOC MEDICINE PRESS LTD, 2012年04月, ACTA RADIOLOGICA, 53(3) (3), 303 - 306, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tomomaro Etoh, Yoh Watanabe, Izumi Imaoka, Takamichi Murakami, Hiroshi Hoshiai
    We report a rare case of adenomyoma localized only in the left fallopian tube mimicking tubal malignant tumor. A 45-year-old woman presented with mild pelvic pain, dysmenorrhea and left adnexal mass. Magnetic resonance imaging showed a solid tumor, suspected primary cancer of the fallopian tube, and serum carbohydrate antigen 125 was elevated to 72 U/mL (normal; 035). At surgery, the tumor was revealed as a left fallopian tube tumor without torsion. Postoperative histopathology showed that the tumor included bundle-like growing non-atypical leiomyoma cells and ectopic normal endometrium accompanied with endometrial stroma and we diagnosed primary adenomyoma of the left fallopian tube. Adenomyoma localized only in the fallopian tube is a rare entity and it can occur only in the fallopian tube.
    WILEY-BLACKWELL, 2012年04月, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 38(4) (4), 721 - 723, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 肝腫瘍造影超音波過去5年の総括と今後の展望 肝細胞癌診断におけるSonazoid造影USの有用性についてEOB造影MRIとの比較
    小来田 幸世, 今井 康陽, 大濱 日出子, 福田 和人, 井倉 技, 澤井 良之, 関 康, 中島 収, 村上 卓道
    (公社)日本超音波医学会, 2012年04月, 超音波医学, 39(Suppl.) (Suppl.), S238 - S238, 日本語

  • Masaru Kubota, Takamichi Murakami, Hiroaki Nagano, Hidetoshi Eguchi, Shigeru Marubashi, Shogo Kobayashi, Hiroshi Wada, Masahiro Tanemura, Keizo Dono, Shoji Nakamori, Masato Sakon, Morito Monden, Masaki Mori, Yuichiro Doki
    BACKGROUND AND AIMS: The purpose of this prospective study was to demonstrate the ability to measure pancreatic tumor tissue blood flow (TBF) with a noninvasive method using xenon inhalation computed tomography (xenon-CT) and to correlate TBF with histological features, particularly microvascular density (MVD). METHODS: TBFs of pancreatic tumors in 14 consecutive patients were measured by means of xenon-CT at diagnosis and following therapy. Serial abdominal CT scans were obtained before and after inhalation of nonradioactive xenon gas. TBF was calculated using the Fick principle. Furthermore, intratumoral microvessels were stained with anti-CD34 monoclonal antibodies before being quantified by light microscopy (×200). We evaluated MVD based on CD34 expression and correlated it with TBF. RESULTS: The quantitative TBF of pancreatic tumors measured by xenon CT ranged from 22.3 to 111.4 ml/min/100 g (mean ± SD, 59.6 ± 43.9 ml/min/100 g). High correlation (r = 0.885, P < 0.001) was observed between TBF and intratumoral MVD. CONCLUSION: Xenon-CT is feasible in patients with pancreatic tumors and is able to accurately estimate MVD noninvasively.
    3, 2012年03月, Digestive diseases and sciences, 57(3) (3), 801 - 5, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • EOB造影MRIとSonazoid造影USを用いた肝細胞癌の検出と分化度診断
    大濱 日出子, 今井 康陽, 小来田 幸世, 福田 和人, 井倉 技, 澤井 良之, 牧野 祐紀, 関 康, 森本 修邦, 高村 学, 竹内 真, 中島 収, 村上 卓道
    (一財)日本消化器病学会, 2012年03月, 日本消化器病学会雑誌, 109(臨増総会) (臨増総会), A272 - A272, 日本語

  • Masayuki Kitano, Masatoshi Kudo, Kenji Yamao, Tadayuki Takagi, Hiroki Sakamoto, Takamitsu Komaki, Ken Kamata, Hajime Imai, Yasutaka Chiba, Masahiro Okada, Takamichi Murakami, Yoshifumi Takeyama
    OBJECTIVES: Contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS), a novel technology, visualizes parenchymal perfusion in the pancreas. This study prospectively evaluated how accurately CH-EUS characterizes pancreatic lesions and compared its diagnostic ability with that of contrast-enhanced multidetector-row computed tomography (MDCT) and endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA). METHODS: A total of 277 consecutive patients with pancreatic solid lesions that were detected by conventional EUS underwent CH-EUS for evaluation of vascularity. After infusing an ultrasound contrast, CH-EUS was performed by using an echoendoscope and a specific mode for contrast harmonic imaging. On the basis of the intensity of enhancement, the lesions were categorized into four patterns: nonenhancement, hypoenhancement, isoenhancement, and hyperenhancement. For comparison, all patients underwent MDCT. The ability of CH-EUS to differentiate ductal carcinomas from the other solid tumors, particularly small lesions (<= 2 cm in diameter) was assessed, and compared with the differentiating abilities of MDCT and EUS-FNA. RESULTS: In terms of reading the CH-EUS images, the kappa-coefficient of the interobserver agreement test was 0.94 (P<0.001). CH-EUS-depicted hypoenhancement diagnosed ductal carcinomas with a sensitivity and specificity of 95.1% (95% confidence interval (CI) 92.7-96.7%) and 89.0% (95% CI 83.0-93.1%), respectively. For diagnosing small carcinomas by CH-EUS, the sensitivity and specificity were 91.2% (95% CI 82.5-95.1%) and 94.4% (95% CI 86.2-98.1%), respectively. CH-EUS-depicted hypervascular enhancement diagnosed neuroendocrine tumors with a sensitivity and specificity of 78.9% (95% CI 61.4-89.7%) and 98.7% (95% CI 96.7-98.8%), respectively. Although CH-EUS and MDCT did not differ significantly in diagnostic ability with regard to all lesions, CH-EUS was superior to MDCT in diagnosing small (<= 2 cm) carcinomas (P<0.05). In 12 neoplasms that MDCT failed to detect, 7 ductal carcinomas and 2 neuroendocrine tumors had hypoenhancement and hyperenhancement on CH-EUS, respectively. When CH-EUS was combined with EUS-FNA, the sensitivity of EUS-FNA increased from 92.2 to 100%. CONCLUSIONS: CH-EUS is useful for characterizing conventional EUS-detected solid pancreatic lesions. EUS equipped with contrast harmonic imaging may play an important role in the characterization of small tumors that other imaging methods fail to depict and may improve the diagnostic yield of EUS-FNA.
    NATURE PUBLISHING GROUP, 2012年02月, AMERICAN JOURNAL OF GASTROENTEROLOGY, 107(2) (2), 303 - 310, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Naoto Hayasaka, Nobuo Nagai, Naoyuki Kawao, Atsuko Niwa, Yoshichika Yoshioka, Yuki Mori, Hiroshi Shigeta, Nobuo Kashiwagi, Masaaki Miyazawa, Takao Satou, Hideaki Higashino, Osamu Matsuo, Takamichi Murakami
    Background: There is an increasing need for animal disease models for pathophysiological research and efficient drug screening. However, one of the technical barriers to the effective use of the models is the difficulty of non-invasive and sequential monitoring of the same animals. Micro-CT is a powerful tool for serial diagnostic imaging of animal models. However, soft tissue contrast resolution, particularly in the brain, is insufficient for detailed analysis, unlike the current applications of CT in the clinical arena. We address the soft tissue contrast resolution issue in this report. Methodology: We performed contrast-enhanced CT (CECT) on mouse models of experimental cerebral infarction and hepatic ischemia. Pathological changes in each lesion were quantified for two weeks by measuring the lesion volume or the ratio of high attenuation area (%HAA), indicative of increased vascular permeability. We also compared brain images of stroke rats and ischemic mice acquired with micro-CT to those acquired with 11.7-T micro-MRI. Histopathological analysis was performed to confirm the diagnosis by CECT. Principal Findings: In the models of cerebral infarction, vascular permeability was increased from three days through one week after surgical initiation, which was also confirmed by Evans blue dye leakage. Measurement of volume and %HAA of the liver lesions demonstrated differences in the recovery process between mice with distinct genetic backgrounds. Comparison of CT and MR images acquired from the same stroke rats or ischemic mice indicated that accuracy of volumetric measurement, as well as spatial and contrast resolutions of CT images, was comparable to that obtained with MRI. The imaging results were also consistent with the histological data. Conclusions: This study demonstrates that the CECT scanning method is useful in rodents for both quantitative and qualitative evaluations of pathologic lesions in tissues/organs including the brain, and is also suitable for longitudinal observation of the same animals.
    PUBLIC LIBRARY SCIENCE, 2012年02月, PLOS ONE, 7(2) (2), e32342, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 顎下腺多形腺腫のMR像
    柏木 伸夫, 筑後 孝章, 中西 克之, 岡嶋 馨, 友田 要, 高橋 洋人, 森 一功, 村上 卓道
    (公社)日本医学放射線学会, 2012年02月, 日本医学放射線学会学術集会抄録集, 71回, S262 - S262, 日本語

  • 慢性GVHDに伴う舌papillomatosisから発生した舌癌の1例
    加藤 里枝子, 勝部 敬, 下野 太郎, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, 2012年02月, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 41 - 41, 日本語

  • Gd-EOB-DTPA造影MRIでの肝機能評価の試み T1 Mapping法を用いて
    勝部 敬, 岡田 真広, 熊野 正士, 藤谷 哲也, 森田 敬裕, 今岡 いずみ, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, 2012年02月, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 43 - 43, 日本語

  • 高速多相撮像を用いた多血性肝細胞癌の最適撮像時間の検討
    香川 祐毅, 岡田 真広, 柳生 行伸, 小塚 健倫, 熊野 正士, 今岡 いずみ, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, 2012年02月, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 47 - 47, 日本語

  • Dual energy CTを用いた肝脂肪の定量評価 ファントム実験と初期臨床経験
    兵頭 朋子, 岡田 真広, 矢田 典久, 工藤 正幸, 香川 祐毅, 熊野 正士, 石井 一成, 工藤 正俊, 村上 卓道
    (公社)日本医学放射線学会, 2012年02月, 日本医学放射線学会学術集会抄録集, 71回, S272 - S272, 日本語

  • ASIRを用いた低電圧肝Dynamic-CTによる被曝低減と造影剤量低減に関する報告
    日高 正二朗, 高橋 洋人, 岡田 真広, 兵頭 朋子, 香川 祐毅, 今岡 いずみ, 石井 一成, 足利 竜一朗, 工藤 正俊, 村上 卓道
    (公社)日本医学放射線学会, 2012年02月, 日本医学放射線学会学術集会抄録集, 71回, S273 - S273, 日本語

  • Yoh Watanabe, Hidekatsu Nakai, Izumi Imaoka, Takamichi Murakami, Hiroshi Hoshiai
    Carcinoma meningitis with uterine cervical cancer is an extremely rare event. We present the clinicopathologic characteristics and diagnostic imaging findings of a patient with advanced small-cell neuroendocrine carcinoma of the cervix who had developed carcinoma meningitis during systematic chemotherapy.
    WILEY-BLACKWELL, 2012年01月, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 38(1) (1), 336 - 339, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Takamichi Murakami, Masahiro Okada, Tomoko Hyodo
    Detection, characterization, staging, and treatment monitoring are major roles of diagnostic imaging of liver cancers. Developments in multidetector-row computed tomography (MDCT) technology have increased the spatial and temporal resolution of CT to allow more precise evaluation of the hemodynamics of liver tumors and improve the diagnostic accuracy of dynamic MDCT. The high spatial and temporal resolutions of dynamic MDCT enable us to reconstruct 3-dimensional (3D) images that are very useful for pretreatment evaluation. Dynamic MR imaging with fast 3D T-1-weighted gradient echo imaging sequence using nonspecific contrast medium can be highly sensitive for detecting hypervascular HCC. However, the use of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), a contrast medium specific to hepatic tissue, offers greater diagnostic ability and, so, has become essential to liver imaging. MR imaging with Gd-EOB-DTPA may replace CT during hepatic arteriography and CT during arterioportography.
    JPN SOC MAGNETIC RESONANCE IN MEDICINE, 2012年, MAGNETIC RESONANCE IN MEDICAL SCIENCES, 11(2) (2), 75 - 81, 英語
    [査読有り]

  • Yuki Makino, Yasuharu Imai, Takumi Igura, Hideko Ohama, Sachiyo Kogita, Yoshiyuki Sawai, Kazuto Fukuda, Hiroshi Ohashi, Takamichi Murakami
    A multimodality fusion imaging system has been introduced for the clinical practice of diagnosis and treatment of hepatocellular carcinoma (HCC), especially for loco-regional treatment. An ultrasonography (US) fusion imaging system can provide a side-by-side display of real-time US images and any cross-sectional images of multiplanar reconstruction of CT or MRI that synchronize real-time US. The US fusion imaging system enables us to perform radiofrequency ablation (RFA) for HCCs difficult to detect on conventional US safely. Besides, we can evaluate the treatment effects of RFA easily at the bedside by combining the contrast-enhanced US and the US fusion imaging system. Fusion images of pre- and post-RFA CT have been utilized for the assessment of the treatment effects of RFA. Although the treatment effects of RFA have been conventionally evaluated, comparing pre- and post-RFA CT side-by-side, the evaluation tends to be in-accurate. On CT fusion images, the tumor and the ablation zone are overlaid and we can grasp the positional relation easily, leading to quantitative and more accurate evaluation. The multi modality fusion imaging system has become quite an important tool for loco-regional treatment of HCC because of its usefulness for both the guidance during the RFA procedure and the evaluation of its treatment effects. Copyright (C) 2012 S. Karger AG, Basel
    KARGER, 2012年, DIGESTIVE DISEASES, 30(6) (6), 580 - 587, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hiromitsu Onishi, Takamichi Murakami, Tonsok Kim, Masatoshi Hori, Keigo Osuga, Mitsuaki Tatsumi, Hiroki Higashihara, Noboru Maeda, Takahiro Tsuboyama, Atsushi Nakamoto, Kaname Tomoda, Noriyuki Tomiyama
    Purpose: To investigate the validity of determining the contrast medium dose based on body surface area (BSA) for the abdominal contrast-enhanced multi-detector row CT comparing with determining based on body weight (BW). Materials and methods: Institutional review committee approval was obtained. In this retrospective study, 191 patients those underwent abdominal contrast-enhanced multi-detector row CT were enrolled. All patients received 96 mL of 320 mg I/mL contrast medium at the rate of 3.2 mL. The iodine dose required to enhance 1 HU of the aorta at the arterial phase and that of liver parenchyma at portal venous phase per BSA were calculated (EU(BSA)) and evaluated the relationship with BSA. Those per BW were also calculated (EU(BW)) and evaluated. Estimated enhancement values (EEVs) of the aorta and liver parenchyma with two protocols for dose decision based on BSA and BW were calculated and patient-to-patient variability was compared between two protocols using the Levene test. Results: The mean of EU(BSA) and EU(BW) were 0.0621 g I/m(2)/HU and 0.00178 g I/kg/HU for the aorta, and 0.342 g I/m(2)/HU and 0.00978 g I/kg/HU for the liver parenchyma, respectively. In the aortic enhancement, EU(BSA) was almost constant regardless of BSA, and the mean absolute deviation of the EEV with the BSA protocol was significantly lower than that with the BW protocol (P < .001), although there was no significant difference between two protocols in the hepatic parenchymal enhancement (P = .92). Conclusion: For the aortic enhancement, determining the contrast medium dose based on BSA was considered to improve patient-to-patient enhancement variability. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
    ELSEVIER IRELAND LTD, 2011年12月, EUROPEAN JOURNAL OF RADIOLOGY, 80(3) (3), 643 - 647, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 今井 康陽, 井倉 技, 小来田 幸世, 澤井 良之, 大濱 日出子, 牧野 祐紀, 福田 和人, 黒川 正典, 森本 修邦, 関 康, 高村 学, 村上 卓道
    (株)医薬情報研究所, 2011年12月, 新薬と臨牀, 60(12) (12), 2519 - 2519, 日本語

  • 兵頭 朋子, 岡田 真広, 香川 祐毅, 熊野 正士, 任 誠雲, 柏木 伸夫, 柳生 行伸, 今岡 いずみ, 足利 竜一朗, 石井 一成, 工藤 正俊, 村上 卓道
    近畿大学医学会, 2011年12月, 近畿大学医学雑誌, 36(3-4) (3-4), 13A - 13A, 日本語

  • 米矢 吉宏, 細野 眞, 土屋 典生, 熊野 正士, 山田 譲, 任 誠雲, 柳生 行伸, 石井 一成, 足利 竜一朗, 西村 恭昌, 村上 卓道
    (一社)日本核医学会, 2011年09月, 核医学, 48(3) (3), S272 - S272, 日本語

  • 柏木伸夫, 村上卓道, 筑後孝章
    2011年09月, ACTA Radiol, 52(9) (9), 951 - 953

  • Masahiro Okada, Takashi Katsube, Seishi Kumano, Yuki Kagawa, Tetsuro Araki, Natsuko Tsuda, Tomoyuki Okuaki, Izumi Imaoka, Noboru Tanigawa, Kazunari Ishii, Takamichi Murakami
    Background: Non-invasive MR imaging is expected to be used for accurate diagnosis and quantification of non-alcoholic steatohepatitis (NASH), because NASH is a progressive fatty liver disease. New MR techniques, such as fat fraction ratio (FFR) and T2* value measurement, have attracted an increasing attention, because those techniques can measure quantitative parameters of fibrosis, fat and iron deposition in the liver. Purpose: To investigate the potential of FFR and T2* value in NASH with pre-enhancement, gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) or super-paramagnetic iron oxide (SPIO)-enhanced MRI. Material and Methods: Twenty-eight rats were divided equally into four groups (one control group and three NASH groups). All rats underwent unenhanced, Gd-EOB-DTPA, and SPIO-enhanced MRI. The T2* value of the liver was measured for each image sequence, and then changes in T2* values before and after each injection were analyzed using Dunnett's test. The reduction rate of T2* value before and 13 min after injection of Gd-EOB-DTPA or SPIO was analyzed using Mann-Whitney's U test. Moreover, FFR of the liver was measured before enhancement, and the relationship between fat fraction and the calculated fat area percentage on a pathological specimen was examined using Spearman's correlation test. Results: On pre-enhancement, FFR and T2* value were 26.0% +/- 12.0% and 21.5 +/- 4.2 ms for all NASH groups, and 0.9% +/- 0.5% and 30.8 +/- -5.5 ms for control, respectively. Both FFR and T2* values were significantly different between the NASH and control groups. The reduction rate of T2* value was significantly lower in the NASH groups than in the control group on SPIO-enhanced MRI, though there was no significant difference on Gd-EOB-DTPA-enhanced MRI. FFR was correlated with the calculated fat area percentage for the pathological specimen. Conclusion: Pre-enhancement FFR, T2* value measurement and reduction rate of T2* value on SPIO-enhanced MRI may help estimate the progress of liver fat deposition and fibrosis in NASH.
    ROYAL SOC MEDICINE PRESS LTD, 2011年07月, ACTA RADIOLOGICA, 52(6) (6), 658 - 664, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masahiro Okada, Tonsok Kim, Takamichi Murakami
    The purpose of this article is to explain the role of advanced liver CT imaging, including perfusion CT, dual-energy CT, and volume helical shuttle (VHS) scanning, with regard to its clinical applications. Perfusion CT is a promising method for calculating hepatic blood flow and portal blood flow, including microcirculation, using a color-encoded display of parameters obtained from the liver time-density curve, with iodine contrast agent. Tumor angiogenesis and assessment of the response to antiangiogenesis treatment (e.g., Sorafenib) can be analyzed by perfusion CT of the liver. VHS scan has very high temporal resolution due to the reciprocating movement employed during scanning, enabling the acquisition of 24 scans of the whole liver in the arterial dominant phase during a 40-s breath hold, and a reduction in radiation dose. Dual-energy CT enables differentiation of materials and tissues based on their CT density values, using two different energy spectra. This method includes a low tube voltage CT technique that increases the contrast enhancement of vascular structures while simultaneously reducing radiation dose. Images obtained at the preferred settings of low tube voltage and high tube current, with dose reduction in the hepatic arterial phase, are useful for detecting hypervascular hepatocellular carcinoma.
    SPRINGER, 2011年06月, ABDOMINAL IMAGING, 36(3) (3), 273 - 281, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Takashi Katsube, Masahiro Okada, Seishi Kumano, Masatoshi Hori, Izumi Imaoka, Kazunari Ishii, Masatoshi Kudo, Hajime Kitagaki, Takamichi Murakami
    Objectives: To investigate the ability of T1 mapping of liver on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging for the estimation of liver function. Materials and Methods: Local institutional review board approved this study. Ninety-one patients (64 men, 27 women; mean age, 67.4 years) were classified into 4 groups as follows: normal liver function (NLF), n = 16; chronic hepatitis (CH), n = 38; liver cirrhosis with Child-Pugh A (LCA), n = 20; and liver cirrhosis with Child-Pugh B (LCB), n = 17. Look-Locker sequences (single slice multiphase imaging using gradient-echo sequence with inversion recovery pulse) were obtained before and at 3, 8, 13, and 18 minutes after Gd-EOB-DTPA administration. T1 mapping of liver parenchyma was calculated from the Look-Locker sequence. T1 relaxation time of liver and reduction rate of T1 relaxation time between pre- and postcontrast enhancement were measured. The Bonferroni t test was used for comparisons between the 4 groups. Results: Precontrast T1 relaxation times were significantly longer for LCA and LCB than for NLF, and that of LCB was longer than that of chronic hepatitis (P < 0.05). Postcontrast T1 relaxation times were significantly longer for LCB than for other groups at all time points. Those of LCA were longer than those of NLF at all time points. Reduction rates were significantly lower for LCB than for the other groups at >= 8 minutes. Conclusions: Evaluation of hepatic uptake of Gd-EOB-DTPA using T1 mapping of liver parenchyma can help estimate liver function.
    LIPPINCOTT WILLIAMS & WILKINS, 2011年04月, INVESTIGATIVE RADIOLOGY, 46(4) (4), 277 - 283, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yuki Kagawa, Masahiro Okada, Seishi Kumano, Takashi Katsube, Izumi Imaoka, Noboru Tanigawa, Kazunari Ishii, Masatoshi Kudo, Takamichi Murakami
    Purpose: To investigate optimal delay time of hepatic arterial phase in Gadoxetate-enhanced MR for detecting hypervascular hepatocellular carcinoma (HCC). Materials and Methods: Forty-five patients with 85 hypervascular HCCs and 9 patients with 16 hypervascular HCCs underwent Gadoxetate-and Gd-DTPA-enhanced MR at 1.5 Tesla (T) system, respectively. All HCCs were analyzed 10-38 s after injection using a time-resolved dynamic MR sequence with keyhole data sampling. Seven sequential phase images (1 phase 4 s) were obtained during a single breath hold of 28 s. Time-intensity curves of the abdominal aorta, liver parenchyma, and HCC were obtained, then aortic contrast arrival time, time of peak HCC enhancement, duration time of HCC and aortic enhancement, and time delay from aortic contrast arrival to peak enhancement of HCC were measured. Results: Aortic contrast arrival time was 15.1 +/- 2.9 s, time of peak HCC enhancement 29.9 +/- 4.6 s, duration time of HCC enhancement 17.4 +/- 6.4 s postinjection of Gadoxetate. Duration of aortic enhancement (23.6 +/- 3.5 s) of Gadoxetate-enhanced MR was significantly less than that of Gd-DTPA-enhanced MR (26.3 +/- 2.8 s) (P < 0.0059). Conclusion: Peak enhancement time of HCC on Gadoxetate-enhanced MR imaging occurred at 14.6 +/- 4.6 s after aortic contrast arrival.
    WILEY-BLACKWELL, 2011年04月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 33(4) (4), 864 - 872, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Naoto Hayasaka, Kazuyuki Aoki, Saori Kinoshita, Shoutaroh Yamaguchi, John K. Wakefield, Sachiyo Tsuji-Kawahara, Kazumasa Horikawa, Hiroshi Ikegami, Shigeharu Wakana, Takamichi Murakami, Ram Ramabhadran, Masaaki Miyazawa, Shigenobu Shibata
    Regulators of G protein signaling (RGS) are a multi-functional protein family, which functions in part as GTPase-activating proteins (GAPs) of G protein alpha-subunits to terminate G protein signaling. Previous studies have demonstrated that the Rgs16 transcripts exhibit robust circadian rhythms both in the suprachiasmatic nucleus (SCN), the master circadian light-entrainable oscillator (LEO) of the hypothalamus, and in the liver. To investigate the role of RGS16 in the circadian clock in vivo, we generated two independent transgenic mouse lines using lentiviral vectors expressing short hairpin RNA (shRNA) targeting the Rgs16 mRNA. The knockdown mice demonstrated significantly shorter free-running period of locomotor activity rhythms and reduced total activity as compared to the wild-type siblings. In addition, when feeding was restricted during the daytime, food-entrainable oscillator (FEO)-driven elevated food-anticipatory activity (FAA) observed prior to the scheduled feeding time was significantly attenuated in the knockdown mice. Whereas the restricted feeding phase-advanced the rhythmic expression of the Per2 clock gene in liver and thalamus in the wild-type animals, the above phase shift was not observed in the knockdown mice. This is the first in vivo demonstration that a common regulator of G protein signaling is involved in the two separate, but interactive circadian timing systems, LEO and FEO. The present study also suggests that liver and/or thalamus regulate the food-entrained circadian behavior through G protein-mediated signal transduction pathway(s).
    PUBLIC LIBRARY SCIENCE, 2011年03月, PLOS ONE, 6(3) (3), 1 - 7, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Gd-EOB-DTPA造影MRIにおけるHCCのT1値の経時的変化について T1 mappingを用いた定量的な検討
    森田 敬裕, 熊野 正士, 岡田 真広, 兵頭 朋子, 柏木 伸夫, 柳生 行伸, 今岡 いずみ, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, 2011年02月, 日本医学放射線学会学術集会抄録集, 70回, S275 - S276, 日本語

  • SSFSE像におけるHCCに対するEOB造影の経時的影響 1.5Tと3.0Tの比較
    荒木 哲朗, 岡田 真広, 熊野 正士, 柳生 行伸, 柏木 伸夫, 小塚 健倫, 今岡 いずみ, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, 2011年02月, 日本医学放射線学会学術集会抄録集, 70回, S276 - S276, 日本語

  • Gd-EOB-DTPA造影MRI肝細胞相で検出された慢性障害肝の乏血性結節 多血化の危険因子
    兵頭 朋子, 岡田 真広, 香川 祐毅, 熊野 正士, 堀 雅敏, 石井 一成, 今井 康陽, 望月 輝一, 工藤 正俊, 村上 卓道
    (公社)日本医学放射線学会, 2011年02月, 日本医学放射線学会学術集会抄録集, 70回, S342 - S343, 日本語

  • 減弱を考慮した副腎皮質アドステロール摂取率の簡易的な算出方法
    大塚 正和, 花岡 宏平, 宇佐美 公男, 澄田 貢, 石井 一成, 村上 卓道, 細野 眞
    (公社)日本放射線技術学会, 2011年02月, 日本放射線技術学会総会学術大会予稿集, 67回, 320 - 320, 日本語

  • 坂口 健太, 高田 裕史, 宇佐美 公男, 米矢 吉宏, 土屋 典生, 熊野 正士, 細野 眞, 花岡 宏平, 大塚 正和, 井上 亮, 新谷 祐子, 吉田 修平, 森元 英夫, 宇都 辰郎, 澄田 貢, 柿木 崇秀, 柳生 行伸, 石井 一成, 足利 竜一郎, 村上 卓道
    (一社)日本核医学会, 2011年02月, 核医学, 48(1) (1), 63 - 64, 日本語

  • 収集時間の減少が123I-IMP脳血流SPECT/CT検査に与える影響について
    花岡 宏平, 坂口 健太, 大塚 正和, 澄田 貢, 石井 一成, 村上 卓道, 細野 眞
    (公社)日本放射線技術学会, 2011年02月, 日本放射線技術学会総会学術大会予稿集, 67回, 251 - 251, 日本語

  • 高速多相撮像を用いた多血性肝細胞癌の最適な撮像時間の検討
    香川祐毅, 岡田真広, 村上卓道
    2011年01月, 近大医学雑誌, 36(1) (1), 19 - 24

  • Takahashi R, Ishii K, Kakigi T, Yokoyama K, Mori E, Murakami T
    1, 2011年01月, Dement Geriatr Cogn Disord Extra, 1, 381 - 392
    [査読有り]

  • Alaboudy A, Inoue T, Hatanaka K, Chung H, Hyodo T, Kumano S, Murakami T, Moustafa EF, Kudo M
    Objective: To clarify the diagnostic ability of combining imaging methods to diagnose hepatocellular carcinoma (HCC) using Sonazoid (R)-enhanced ultrasound (US), gadolinium diethylene-triamine-pentaacetic acid-enhanced (Gd-EOB-DTPA) magnetic resonance imaging (MRI), and contrast-enhanced computed tomography (CECT). Methods: A total of 32 patients who underwent surgical resection for HCC were studied. Sonazoid-enhanced US, Gd-EOB-DTPA MRI, CECT, and intraoperative contrast-enhanced ultrasonography were done for all patients. The definitive diagnosis of HCC in those patients was based on histopathological confirmation. Results: A total of 50 histologically proven HCCs were obtained from 32 patients; their mean (+/-SD) age was 68.3 years +/-8.1. The mean (+/-SD) nodule size was 2.6 cm +/- 1.9. Twenty percent were well-differentiated HCC, 64% were moderately differentiated HCC, 10% were poorly differentiated HCC, 4% were combined HCC and CCC, and 2% were HCC with severe necrosis. The overall diagnostic sensitivity of CEUS, CECT, and Gd-EOB-DTPA MRI was 72, 74, and 86%, respectively; however, there was no significant difference between the three imaging modalities in diagnosing typical HCC (p = 0.092). When combining the diagnostic ability of the different imaging modalities, the diagnostic sensitivity of Sonazoid-enhanced US and Gd-EOB-DTPA MRI was 90%, while addition of Sonazoid-enhanced US to CECT and CECT to Gd-EOB-DTPA MRI had a sensitivity of 82 and 88%, respectively. There was no significant difference between the three imaging combinations (p = 0.970). Conclusion: Sonazoid-enhanced US and Gd-EOB-DTPA MRI can be confidently used in daily clinical practice for the management of HCC. Copyright (C) 2011 S. Karger AG, Basel
    KARGER, 2011年, Oncology, 81(Suppl 1) (Suppl 1), 66 - 72, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Takamichi Murakami, Yasuharu Imai, Masahiro Okada, Tomoko Hyodo, Won-Jae Lee, Myeong-Jin Kim, Tonsok Kim, Byung Ihn Choi
    Detection, characterization, staging, and treatment monitoring are major roles in imaging diagnosis in liver cancers. Contrast-enhanced ultrasonography (CEUS) using micro-bubble contrast agents has expanded the role of US in the detection and diagnosis of liver nodules in patients at high risk of hepatocellular carcinoma (HCC). CEUS provides an accurate differentiation between benign and malignant liver nodules, which is critical for adequate management of HCC and is also useful for guidance of percutaneous local therapy of HCC and postprocedure monitoring of the therapeutic response. The technology of multidetector-row computed tomography (MDCT) has increased spatial and temporal resolutions of computed tomography (CT). It has made possible a more precise evaluation of the hemodynamics of liver tumor, and the diagnostic accuracy of dynamic MDCT has improved. Perfusion CT can measure tissue perfusion parameters quantitatively and can assess segmental hepatic function. Dynamic MDCT with high spatial and temporal resolution enables us to reconstruct 3- and 4-dimensional imaging, which is very useful for pretreatment evaluation. Dual-energy CT makes possible the differentiation of materials and tissues in images obtained based on the differences in iodine and water densities. Monochromatic images, which can be reconstructed by dual-energy CT data, provide some improvement in contrast and show a higher contrast-to-noise ratio for hypervascular HCCs. Dynamic magnetic resonance imaging with fast imaging sequence of 3-dimensional Fourier transformation T(1)-weighted gradient echo and nonspecific contrast medium can show high detection sensitivity of hypervascular HCC. However, the hepatic tissue-specific contrast medium, gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid, has become an essential contrast medium for liver imaging because of its higher diagnostic ability. It may replace CT during hepatic arteriography and during arterioportography. Copyright (C) 2011 S. Karger AG, Basel
    KARGER, 2011年, ONCOLOGY, 81, 86 - 99, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 拡散強調像で大脳白質に広範な高信号を認めたShaken Baby Syndromeの1例
    朝戸 信行, 下野 太郎, 加藤 里枝子, 藤谷 哲也, 森田 敬裕, 柿木 崇秀, 香川 祐毅, 安藤 理奈, 栗生 明博, 勝部 敬, 桑原 雅知, 柳生 行伸, 岡田 真広, 熊野 正士, 今岡 いずみ, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, 2011年01月, Japanese Journal of Radiology, 29(Suppl.I) (Suppl.I), 50 - 50, 日本語

  • 照射野外固定の卵巣病変およびその機能性変化
    香川 祐毅, 今岡 いずみ, 加藤 里枝子, 安藤 里奈, 桑原 雅知, 岡田 真広, 熊野 正士, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, 2011年01月, Japanese Journal of Radiology, 29(Suppl.I) (Suppl.I), 57 - 57, 日本語

  • Sachiyo Kogita, Yasuharu Imai, Masahiro Okada, Tonsok Kim, Hiromitsu Onishi, Manabu Takamura, Kazuto Fukuda, Takumi Igura, Yoshiyuki Sawai, Osakuni Morimoto, Masatoshi Hori, Hiroaki Nagano, Kenichi Wakasa, Norio Hayashi, Takamichi Murakami
    To retrospectively investigate enhancement patterns of hepatocellular carcinoma (HCC) and dysplastic nodule (DN) in the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced MRI in relation to histological grading and portal blood flow. Sixty-nine consecutive patients with 83 histologically proven HCCs and DNs were studied. To assess Gd-EOB-DTPA uptake, we calculated the EOB enhancement ratio, which is the ratio of the relative intensity of tumorous lesion to surrounding nontumorous area on hepatobiliary phase images (post-contrast EOB ratio) to that on unenhanced images (pre-contrast EOB ratio). Portal blood flow was evaluated by CT during arterial portography. Post-contrast EOB ratios significantly decreased as the degree of differentiation declined in DNs (1.00 +/- 0.14) and well, moderately and poorly differentiated HCCs (0.79 +/- 0.19, 0.60 +/- 0.27, 0.49 +/- 0.10 respectively). Gd-EOB-DTPA uptake, assessed by EOB enhancement ratios, deceased slightly in DNs and still more in HCCs, while there was no statistical difference in the decrease between different histological grades of HCC. Reductions in portal blood flow were observed less frequently than decreases in Gd-EOB-DTPA uptake in DNs and well-differentiated HCCs. Reduced Gd-EOB-DTPA uptake might be an early event of hepatocarcinogenesis, preceding portal blood flow reduction. The hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI may help estimate histological grading, although difficulties exist in differentiating HCCs from DNs.
    SPRINGER, 2010年10月, EUROPEAN RADIOLOGY, 20(10) (10), 2405 - 2413, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masahiro Okada, Yasuharu Imai, Tonsok Kim, Sachiyo Kogita, Manabu Takamura, Seishi Kumano, Hiromitsu Onishi, Masatoshi Hori, Kazuto Fukuda, Norio Hayashi, Kenichi Wakasa, Michiie Sakamoto, Takamichi Murakami
    Purpose: To compare enhancenent patterns of hepatocellular carcinoma (HCC) and dysplastic nodule (DN) between gadoxetate- and ferucarbotran-enhanced MRI. Materials and Methods: Patients recruited from ultrasound surveillance for HCC in chronic liver diseases were enrolled in this prospective study approved by institutional review board. Thirty-six patients with 37 histologically proven HCC, including 22 well-differentiated HCCs (wHCC), 15 moderately to poorly differentiated HCCs (mpHCCs), and 4 DNs, underwent gadoxetate-enhanced and ferucarbotran-enhanced MRI. We compared hepatobiliary phase image of gadoxetate-enhanced MRI with ferucarbotran-enhanced MR image regarding signal intensity of HCC and DN relative to surrounding liver parenchyma. We calculated contrast ratios between tumor and liver on pre-enhancement, hepatobiliary phase of gadoxetate-enhanced MRI and ferucarbotran-enhanced MRI. Results: On ferucarbotran-enhanced MRI, all mpHCCs showed hyper-intensity, while 14 wHCCs (14/22; 63%) showed iso-intensity. On hepatobiliary phase of gadoxetate-enhanced MRI, 13 mpHCCs (13/15; 86%) and 20 wHCCs (20/22; 91%) showed hypo-intensity. Two DNs and the other two showed iso- and hypo-intensity, respectively, on gadoxetate-enhanced MRI, whereas all DNs revealed iso-intensity on ferucarbotran-enhanced MRI. Gadoxetate-postcontrast ratio was significantly lower than ferucarbotran-postcontrast ratio in wHCC (P = 0.015). Conclusion: The uptake function of hepatocytes that are targeted by gadoxetate is more sensitive than that of Kupffer cells targeted by ferucarbotran in stepwise hepatocarcinogenesis.
    JOHN WILEY & SONS INC, 2010年10月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 32(4) (4), 903 - 913, 英語
    [査読有り]
    研究論文（学術雑誌）

  • RI標識モノクローナル抗体療法におけるIn-Zevalin、FDGの腫瘍集積と奏効の関係について
    花岡 宏平, 細野 眞, 米矢 吉宏, 土屋 典生, 山添 譲, 宇佐美 公男, 澄田 貢, 石井 一成, 村上 卓道
    (一社)日本核医学会, 2010年09月, 核医学, 47(3) (3), 432 - 432, 日本語

  • Estimation of Liver Function Using T1 Mapping on Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid-enhanced Magnetic Resonance Imaging.
    Katsube T, Okada M, Kumano S, Hori M, Imaoka I, Ishii K, Kudo M, Kitagaki H, Murakami T
    Lippincott Williams & Wilkins, 2010年08月, Invest Radiol, 46, 277 - 283, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masahiro Okada, Norihide Sato, Kazunari Ishii, Kaname Matsumura, Makoto Hosono, Takamichi Murakami
    Malignant lymphoma is the most common form of hematologic cancer, yet because of advanced methods of assessment, the traditional histology-based classification of lymphoma is insufficient for understanding lymphoma imaging. Still, radiologists should be familiar with the imaging findings in lymphoma. Integrated positron emission tomography (PET) computed tomography (CT) allows improved diagnostic accuracy, and uptake of 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) can help predict response during treatment. The sensitivity and specificity of FDG PET are superior to those of gallium 67 scintigraphy in all but indolent lymphoma. Both magnetic resonance (MR) imaging and CT allow excellent assessment of bone texture, but FDG PET is superior in demonstrating bone marrow metabolic activity. Thus, FDG PET is important in both the primary diagnosis and the evaluation of therapy in lymphoma. It may be difficult to determine whether residual abnormalities seen after the completion of chemotherapy radiation therapy represent residual tumor or fibrotic tissue, but PET/CT may allow more accurate diagnosis than MR imaging or CT, thereby helping identify patients who require more intensive treatment. Some diagnostic pitfalls are encountered at FDG PET. However, anatomic CT helps localize and define disease and avoid these potential pitfalls. (c) RSNA, 2010 . radiographics.rsna.org
    RADIOLOGICAL SOC NORTH AMERICA, 2010年07月, RADIOGRAPHICS, 30(4) (4), 939 - 960, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Takamichi Murakami
    5, 2010年05月, Journal of Japanese Society of Gastroenterology, 107(5) (5), 693 - 702, 日本語
    [査読有り]
    研究論文（学術雑誌）

  • Masahiro Okada, Takeshi Isoda, Seishi Kumano, Yuki Kagawa, Tetsuro Araki, Hiromitsu Onishi, Masatoshi Hori, Tonsok Kim, Yasuyuki Motokui, Takeshi Wada, Takamichi Murakami
    Kupffer cell imaging is a powerful tool for the detection of liver cancer. This diagnostic procedure depends on the faculty of the reticuloendothelial system (RES) which takes up foreign bodies, including small particles. The current study aimed to develop a novel RES targeting liposomal contrast agent that functionalized with serine or mannose, the moiety specifically binding to a corresponding receptor on phagocytic cells. Liposomes loaded with non-ionic X-ray contrast media, lohexol, were prepared by supercritical carbon dioxide reverse-phase evaporation method and were intravenously injected to healthy rabbits in order to evaluate the liver parenchymal enhancement in X-ray computed tomography (CT). From 10 to 40 min after injection, the mean enhancement value of the liver parenchyma approached 45 and 34 Hounsfield units (HU) when serine-modified iodinated liposomal contrast agent (ILCA) and mannose-modified ILCA were applied, respectively. The tumor-to-liver contrast values were also evaluated after the administration of the prepared ILCA to rabbits with VX-2 carcinoma. For serine-modified ILCA, tumor-to-liver contrast was 82 HU at 1 min and >24 HU at 10-40 min; for mannose-modified ILCA, the values were 58 HU at 0.5 min and >21 HU at 10-40 min. These vales estimated from the region of intrest and the imaging figures of liver indicate the potential of ILCA for clinical use. Copyright (C) 2010 John Wiley & Sons, Ltd.
    WILEY-HINDAWI, 2010年05月, CONTRAST MEDIA & MOLECULAR IMAGING, 5(3) (3), 140 - 146, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tomoaki Ichikawa, Kazuhiro Saito, Naoki Yoshioka, Akihiro Tanimoto, Takehiko Gokan, Yasuo Takehara, Takeshi Kamura, Toshifumi Gabata, Takamichi Murakami, Katsuyoshi Ito, Shinji Hirohashi, Akihiro Nishie, Yoko Saito, Hiroaki Onaya, Ryohei Kuwatsuru, Atsuko Morimoto, Koji Ueda, Masayo Kurauchi, Josy Breuer
    Objectives: To prospectively evaluate the safety and efficacy of combined unenhanced and gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) imaging compared with unenhanced MR imaging and triphasic contrast-enhanced spiral computed tomography (CT) for the detection and characterization of focal liver lesions. Materials and Methods: The study was reviewed and approved by the institutional review board at each of the 15 centers involved in the study, and informed written consent was given by all patients. In total, 178 patients with suspected focal hepatic lesions (based, in most patients, on CT, tumor marker and ultrasound examinations) underwent combined MR imaging with a single, rapid injection of Gd-EOB-DTPA 0.025 mmol/kg, including T1-weighted dynamic and delayed MR images 20 to 40 minutes postinjection. Triphasic contrast-enhanced CT, the comparator examination, was performed within 4 weeks of MR imaging. Standard of references (SOR) were resection histopathology and intraoperative ultrasonography, or combined CT during arterial portography and CT hepatic arteriography; in cases where, although the major lesions were treated, some lesion(s) were not treated, follow-up superparamagnetic iron oxide-enhanced MR imaging was additionally performed. All images were assessed for differences in lesion detection and characterization (specific lesion type) by on-site readers and 3, blinded (off-site) reviewers. All adverse events (AEs) occurring within 72 hours after Gd-EOB-DTPA administration were reported. Results: Overall, 9.6% of patients who received Gd-EOB-DTPA reported 21 drug-related AEs. A total of 151 patients were included in the efficacy analysis. Combined MR imaging showed statistically higher sensitivity in lesion detection (67.5%-79.5%) than unenhanced MR imaging (46.5%-59.1%; P < 0.05 for all). Combined MR imaging also showed higher sensitivity in lesion detection than CT (61.1%-73.0%), with the results being statistically significant (P < 0.05) for on-site readers and 2 of 3 blinded readers. Higher sensitivity in lesion detection with combined MR imaging compared with CT was also clearly demonstrated in the following subgroups: lesions with a diameter <= 20 mm (lesions <= 10 mm: 38.0%-55.4% vs. 26.1%-47.3%, respectively; lesions 10-20 mm: 71.1%-87.3% vs. 65.7%-78.4%, respectively); in cirrhotic patients (64.5%-75.4% vs. 54.5%-70.3%, respectively); and in patients with hepatocellular carcinoma (66.6%-78.6% vs. 59.1%-71.6%, respectively). Combined MR imaging demonstrated a higher proportion of correctly characterized lesions (50.5%-72.1%) than unenhanced MR imaging (30.2%-50.0%; P < 0.05 for all), whereas there were no significant differences compared with CT (49.0%-68.1%), except for one blinded reader (P < 0.05). Conclusion: In this study, hepatocyte-specific Gd-EOB-DTPA was shown to be safe and to improve the detection and characterization of focal hepatic lesions compared with unenhanced MR imaging. When compared with spiral CT, Gd-EOB-DTPA enhanced MRI seems to be beneficial especially for the detection for smaller lesions or hepatocellular carcinoma underlying cirrhotic liver.
    LIPPINCOTT WILLIAMS & WILKINS, 2010年03月, INVESTIGATIVE RADIOLOGY, 45(3) (3), 133 - 141, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Akihiro Kuriu, Taro Shimono, Masatomo Kuwabara, Ryuichiro Ashikaga, Makoto Hosono, Takamichi Murakami
    We report a case of fourth ventricular mixed germ cell tumor (GCT) in a 20-year-old man. Neuroradiological investigations revealed a fourth ventricular hemorrhagic tumor with adipose tissue. We suspected mixed GCT because adipose tissue was seen preoperatively, but mixed GCT occurring after childhood in this location has not previously been reported. We describe herein the imaging findings for mixed GCT and discuss the differential diagnoses of fourth ventricular tumors with adipose tissue. © 2010 Japan Radiological Society.
    2, 2010年02月, Japanese Journal of Radiology, 28(2) (2), 166 - 168, 英語
    [査読有り]
    研究論文（学術雑誌）

  • MRIおよびCTを用いた画像的肝機能評価
    岡田 真広, 熊野 正士, 勝部 敬, 香川 祐毅, 栗生 明博, 今岡 いずみ, 石井 一成, 今井 康陽, 工藤 正俊, 村上 卓道
    (公社)日本医学放射線学会, 2010年02月, 日本医学放射線学会学術集会抄録集, 69回, S134 - S134, 日本語

  • SPECT/CTによる脳血流SPECTの減弱補正効果
    栗生 明博, 石井 一成, 米谷 吉宏, 柳生 行伸, 熊野 正士, 足利 竜一朗, 細野 眞, 村上 卓道
    (公社)日本医学放射線学会, 2010年02月, 日本医学放射線学会学術集会抄録集, 69回, S183 - S184, 日本語

  • 油性造影剤マイオジールの頭蓋内MRI所見についての検討
    下野 太郎, 足利 竜一朗, 柳生 行伸, 桑原 雅知, 勝部 敬, 栗生 明博, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, 2010年02月, 日本医学放射線学会学術集会抄録集, 69回, S206 - S206, 日本語

  • 3T MRI高分解能画像による正常子宮の蠕動評価
    安藤 理奈, 今岡 いずみ, 香川 祐毅, 加藤 里枝子, 柳生 行伸, 岡田 真広, 熊野 正士, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, 2010年02月, 日本医学放射線学会学術集会抄録集, 69回, S274 - S275, 日本語

  • Gd-EOB-DTPA造影MRIと肝機能評価 T1 Mapping法を用いて
    勝部 敬, 岡田 真広, 熊野 正士, 香川 祐毅, 栗生 明博, 奥秋 知幸, 今岡 いずみ, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, 2010年02月, 日本医学放射線学会学術集会抄録集, 69回, S293 - S293, 日本語

  • 多血性肝細胞癌におけるGd-EOB-DTPA造影ダイナミックMRIの診断能 造影ダイナミックCTとの比較
    大西 裕満, 村上 卓道, 今井 康陽, 金 東石, 堀 雅敏, 坪山 尚寛, 中本 篤, 中矢 泰裕, 高村 学, 熊野 正士
    (公社)日本医学放射線学会, 2010年02月, 日本医学放射線学会学術集会抄録集, 69回, S243 - S243, 日本語
    [査読有り]

  • Akihiro Kuriu, Taro Shimono, Masatomo Kuwabara, Ryuichiro Ashikaga, Makoto Hosono, Takamichi Murakami
    We report a case of fourth ventricular mixed germ cell tumor (GCT) in a 20-year-old man. Neuroradiological investigations revealed a fourth ventricular hemorrhagic tumor with adipose tissue. We suspected mixed GCT because adipose tissue was seen preoperatively, but mixed GCT occurring after childhood in this location has not previously been reported. We describe herein the imaging findings for mixed GCT and discuss the differential diagnoses of fourth ventricular tumors with adipose tissue.
    SPRINGER, 2010年02月, JAPANESE JOURNAL OF RADIOLOGY, 28(2) (2), 166 - 168, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 64列多列化CTを用いた新しい定量的心筋灌流イメージング法
    中内祥文, 岩永善高, 生田新一郎, 村上卓道
    2010年, 近畿大学医学雑誌, 35(3,4) (3,4)

  • 三次元CT画像を用いた冠動脈の起始異常および開口部起始位置の解剖学的調査
    工藤正幸, 村上卓道
    2010年, 近畿大学医学雑誌, 35(3,4) (3,4), 177 - 184

  • MR cholangiopancreatography at 3.0 T: Intra-individual comparative study with MR cholangiopancreatography at 1.5 T for clinical patients.
    大西裕満, 村上卓道, 金 東石
    2010年, Invest Radiol, 44, 559 - 565

  • Hiroki Higashihara, Takamichi Murakami, Tonsok Kim, Masatoshi Hori, Hiromitsu Onishi, Saki Nakata, Keigo Osuga, Kaname Tomoda, Hironobu Nakamura
    Purpose: To evaluate ability of ferucarbotran-enhanced MR imaging (MRI) in differentiating metastases from nonsolid benign lesions of the liver according to signal-intensity characteristics. Materials and methods: Sixty-six consecutive patients, who had 138 focal hepatic lesions (26 cysts, 11 hemangiomas,and 101 metastases), underwent ferucarbotran-enhanced MRI. The signal-intensity pattern of each kind of lesion relative to the liver parenchyma on ferucarbotran-enhanced T2* and heavily T1-weighted gradient-echo images were assessed and categorized into the following three categories: high-intensity and iso-intensity, respectively (category A), high and low (category B), and iso- and low-intensity (category C). For category B, lesions were subdivided into two groups based on single-shot half-Fourier RARE images: category B1 (not significantly high-intensity) and category B2 (significantly high-intensity). Results: Category A had 11 hemangiomas and 2 metastatic tumors, category B1 had 97 metastatic tumors, category B2 had 2 metastatic tumors and 9 cysts, and category C had 17 cysts. When a tumor with a signal intensity of category A was considered to be hemangioma, category Ell metastasis, and category B2 and C cyst, the diagnostic accuracy for differentiating these lesions was 97% (134/138). Conclusion: The combination of signal-intensity pattern on ferucarbotran-enhanced T2*- and heavily T1-weighted gradient-echo MRI has ability to differentiate liver metastases from nonsolid benign lesions. However, T2-weighted single-shot half-Fourier RARE imaging should also be employed to achieve better performance. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
    ELSEVIER IRELAND LTD, 2010年01月, EUROPEAN JOURNAL OF RADIOLOGY, 73(1) (1), 125 - 130, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Natsuko Tsuda, Masahiro Okada, Takamichi Murakami
    Purpose: We investigated whether the gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI was useful for nonalcoholic steatohepatitis (NASH) staging based on the severity of liver fibrosis. Materials and methods: Twenty-one male Sprague-Dawley rats aged 7 weeks, weighing about 150 g in NASH group were fed a choline-deficient diet for 4, 7 or 10 weeks, and seven rats in the control group were fed a standard diet (n = 7). After the feeding period, the rats were subjected to contrast-enhanced MRI (2D-FLASH; TR/TE = 101/2.9 ms, flip angle 90 degrees). Gd-DTPA (0.1 mmol Gd/kg) and Gd-EOB-DTPA (0.025 mmol Gd/kg) were injected at 24-h intervals, and the speed of contrast injection was 1 mL/s. Signal intensities of the liver were measured and the relative enhancement (RE), the time of maximum RE (T(max)) and elimination half-life of RE (T(1/2)) in the liver were compared. The fibrosis rate (%) was calculated with the following formula: fibrosis/whole area x 100. Results: The fibrosis rates of each group were as follows: 0.52, 0.79, 2.84, and 0.50% (4, 7, 10 weeks and control groups). The fibrosis rate of the 10 weeks group was significantly higher than the control and 4 or 7 weeks groups. Although there was no difference between the T(max) and T(1/2) of each group after Gd-DTPA injection, the T(max) and T(1/2) of the 10 weeks group were significantly prolonged in comparison with the control and 4 or 7 weeks groups after Gd-EOB-DTPA injection (p < 0.01). There was a significant correlation between the fibrosis rate and T(max) or T(1/2) after Gd-EOB-DTPA injection (r = 0.90 or 0.97). Conclusion: It was possible to assess the progress of liver fibrosis in NASH by evaluating the signal intensity-time course on Gd-EOB-DTPA-enhanced MRI. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
    ELSEVIER IRELAND LTD, 2010年01月, EUROPEAN JOURNAL OF RADIOLOGY, 73(1) (1), 137 - 142, 英語
    [査読有り]
    研究論文（学術雑誌）

  • A. Okada, Y. Morita, H. Fukunishi, K. Takeichi, T. Murakami
    Objectives To describe the learning curve effect of magnetic resonance-guided focused ultrasound surgery (MRgFUS) on the outcomes of patients treated for uterine fibroids in four centers in Japan. Methods The extent of fibroid ablation (often used to measure treatment success) was evaluated using the non-perfused volume (NPV) ratio in 287 Japanese patients. The patients were divided into two equal groups according to the chronological treatment time and results were compared between these groups to estimate the learning curve effect. Results were also compared with published data from clinical trials. Results The NPV ratio increased chronologically, from 39.3% to 54.0% (P < 0.001), indicating increasing effectiveness of the treatment with experience. The mean NPV ratios for the entire patient population were over double that of previous clinical trials 46.6% vs. 21.9%; P < 0.001). No serious complications were reported. Conclusion The learning process and accumulation of data on MRgFUS enable the optimization of treatments in order to safely achieve large NPV ratios and sustained clinical benefit. Copyright (C) 2009 ISUOG. Published by John Wiley & Sons, Ltd.
    JOHN WILEY & SONS LTD, 2009年11月, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 34(5) (5), 579 - 583, 英語
    研究論文（学術雑誌）

  • Akihiro Tanimoto, Jeong Min Lee, Takamichi Murakami, Alexander Huppertz, Masatoshi Kudo, Luigi Grazioli
    Discussion at the 2nd Forum for Liver MRI: The International Primovist (R) User Meeting on the use of the hepatocyte-specific contrast agent gadolinium-ethoxybenzyl-diethylene triamine penta-acetic acid (Gd-EOB-DTPA) is reported. Changes to the currently recommended Gd-EOB-DTPA imaging protocol were identified that can reduce the overall examination time. The potential benefits of 3-T MR imaging using Gd-EOB-DTPA have yet to be fully explored. Data show that Gd-EOB-DTPA-enhanced MRI allows identification of liver lesions and provides a differential diagnosis of hepatocellular nodules in the non-cirrhotic and cirrhotic liver, based on vascularity, during the dynamic arterial, portal-venous and late phases, and during the hepatocytespecific phase. Current European, American and Japanese guidelines for the diagnosis of hepatocellular carcinoma need to take into account the recent rapid advances in liver imaging. Based on published clinical trials and the experience of the attendees in the use of Gd-EOB-DTPA in liver imaging, a new simplified, non-invasive diagnostic algorithm was proposed that would be applicable to both Eastern and Western clinical practice in the evaluation of hepatocarcinogenesis and hepatocellular carcinoma. Preliminary clinical experience suggests that Gd-EOB-DTPA may also provide an innovative and cost-effective one-stop approach for staging rectal cancer using whole-body imaging.
    SPRINGER, 2009年10月, EUROPEAN RADIOLOGY, 19(5) (5), S975 - S989, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hiromitsu Onishi, Tonsok Kim, Masatoshi Hori, Takamichi Murakami, Mitsuaki Tatsumi, Yasuhiro Nakaya, Atsushi Nakamoto, Keigo Osuga, Kaname Tomoda, Hironobu Nakamura
    Objectives: To prospectively evaluate the image quality and diagnostic accuracy of magnetic resonance cholangiopancreatography (MRCP) at 3.0 T compared with that at 1.5 T used for patients. Materials and Methods: This study was approved by our institutional review board, and informed consent was obtained from all patients. Three-dimensional MRCP with both a 1.5-T system and a 3.0-T system was administered to 33 consecutive patients suspected of having biliary and/or pancreatic diseases. For 3-dimensional MRCP imaging, a respiratory-triggered Fast Recovery Fast Spin Echo sequence with the parallel imaging technique was used for both systems. The spatial resolution at 1.5 T was matched to that at 3.0 T, and matrix size was 512 X 160, field of view (FOV) 36 X 36 cm, slice thickness 2 mm, and the number of slices ranged from 44 to 54. Repetition time varied according to the patients' respiratory cycles, which ranged from 3000 milliseconds to 6000 milliseconds, and effective echo time, ranging from 391 milliseconds to 482 milliseconds, was automatically determined by the systems. Contrast of imaging of the common bile duct versus that of the periductal tissue was quantitatively evaluated. The image quality for homogeneity of signal intensity, image noise, susceptibility artifacts, and overall imaging quality and diagnostic accuracy for stenoses of bile and main pancreatic ducts and for pancreatic cystic lesions were qualitatively evaluated. The results for 1.5- and 3.0-T were then compared statistically, by using the paired t test for quantitative evaluation of contrast between the common bile duct and the periductal tissue, the Wilcoxon signed rank test for visual evaluation of the image quality, and the McNemar chi(2) test for evaluation of sensitivity and specificity for diagnostic purposes. A P value of less than 0.05 was considered to indicate a statistically significant difference. Results: Contrast of the common bile duct versus that of the periductal tissue at 3.0 T was superior to that at 1.5 T (P < 0.001). In the visual evaluation, image quality at 3.0 T was superior to that at 1.5 T for evaluation of image noise (P < 0.001), overall image quality (P < 0.001), and delineation of intrahepatic bile ducts (P < 0.01) and the main pancreatic duct (P < 0.05), whereas there were no significant differences in homogeneity of signal intensity and in susceptibility artifacts. The diagnostic accuracy for 3.0 T was approximately equivalent to that for 1.5 T. Conclusion: Our results for patients with biliary and pancreatic diseases demonstrate a marked improvement in contrast of the common bile duct versus that of the periductal tissue and image quality including image noise at 3.0 T compared by 1.5 T when identical spatial resolution configuration were used. The results suggest that 3.0 T may allow higher spatial resolution and offer promise for improved diagnosis in MRCP, although further investigations using optimize scan parameters will be needed before its full potential can be achieved.
    LIPPINCOTT WILLIAMS & WILKINS, 2009年09月, INVESTIGATIVE RADIOLOGY, 44(9) (9), 559 - 565, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masatoshi Hori, Tonsok Kim, Takamichi Murakami, Izumi Imaoka, Hiromitsu Onishi, Atsushi Nakamoto, Yasuhiro Nakaya, Kaname Tomoda, Tateki Tsutsui, Takayuki Enomoto, Tadashi Kimura, Hironobu Nakamura
    Purpose: To prospectively compare magnetic resonance imaging (MRI) at 3.0 T and 1.5 T in the same patients for preoperative evaluation of endometrial carcinoma. Materials and Methods: Thirty consecutive patients with endometrial carcinoma underwent MRI at both 3.0 T and 1.5 T as well as surgery. Quantitative and qualitative analyses were performed. Two radiologists independently evaluated images. MR findings were compared with surgicopathologic findings. Results: Image homogeneity of T2-weighted images at 3.0 T was significantly inferior to that at 1.5 T (P = 0.007). The scores of image homogeneity and susceptibility artifacts were not significantly different between 3.0 T gadolinium-enhanced imaging and 1.5 T imaging (P = 0.09 and 0.36). Kappa statistics showed good interobserver agreement between the two radiologists for local-regional staging on T2-weighted images (kappa>0.6). The area under the receiver operating characteristic curve (Az) values for T2-weighted imaging in terms of myometrial invasion, cervical invasion, and lymph node metastases were 0.88 (3.0 T) versus 0.91 (1.5 T), 0.84 versus 0.83, and 0.94 versus 0.95 for reader 1, respectively. There were no significant differences between imaging at 3.0 T and at 1.5 T in Az values for either reader (P > 0.35). Conclusion: 3.0 T MRI is an equivalent imaging modality to 1.5 T imaging for presurgical evaluation of endometrial carcinoma, although not significantly superior to 1.5 T imaging.
    JOHN WILEY & SONS INC, 2009年09月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 30(3) (3), 621 - 630, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 統計的逐次近似法の割合を変化させたCT画像の物理評価
    小西 達朗, 黒川 敏昭, 多田 佳司, 上村 正信, 山田 浩司, 坂口 健太, 村上 卓道, 工藤 正幸
    (公社)日本放射線技術学会, 2009年09月, 日本放射線技術学会雑誌, 65(9) (9), 1298 - 1298, 日本語

  • Seishi Kumano, Masahiko Uemura, Toyoaki Haraikawa, Masaaki Hirata, Keiichi Kikuchi, Tonsok Kim, Masahiro Okada, Teruhito Mochizuki, Takamichi Murakami
    Purpose. The aim of this study was to evaluate the efficacy of double arterial phase dynamic magnetic resonance imaging (MRI) with the sensitivity encoding technique (SENSE dynamic MRI) for detection of hypervascular hepatocellular carcinoma (HCC) in comparison with double arterial phase dynamic multidetector-row helical computed tomography (dynamic MDCT). Materials and methods. A total of 28 patients with 66 hypervascular HCCs underwent both double arterial SENSE dynamic MRI and dynamic MDCT. The diagnosis of HCC was based on surgical resection (n = 7), biopsy (n = 10), or a combination of CT during arterial portography (CTAP), CT during hepatic arteriography (CTA), and/or the 6-month follow-up CT (n = 49). Based on alternative-free response receiving operating characteristic (ROC) analysis, the diagnostic performance for detecting HCC was compared between double arterial phase SENSE dynamic MRI and double arterial phase dynamic MDCT. Results. The mean sensitivity, positive predictive value, and mean A(z) values for hypervascular HCCs were 72%, 80%, and 0.79, respectively, for SENSE dynamic MRI and 66%, 92%, and 0.78, respectively, for dynamic MDCT. The mean sensitivity for double arterial phase SENSE dynamic MRI was higher than that for double arterial phase dynamic MDCT, but the difference was not statistically significant. Conclusion. Double arterial phase SENSE dynamic MRI is as valuable as double arterial phase dynamic MDCT for detecting hypervascular HCCs.
    SPRINGER, 2009年07月, JAPANESE JOURNAL OF RADIOLOGY, 27(6) (6), 229 - 236, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hiromitsu Onishi, Norikazu Masuda, Kayo Takechi, Takahiro Nakayama, Masayuki Tatsuta, Naoki Mihara, Manabu Takamura, Yutaka Inoue, Keiko Kuriyama, Yoshikazu Kotsuma, Hiroshi Furukawa, Takamichi Murakami, Hironobu Nakamura
    Rationale and Objectives. The aim of this study was to evaluate the breast cancer diagnostic capability of "dual-side readout" computed radiography-based mammography (DRCRM) with a 50-mu m pixel size compared to that of conventional film-screen mammography (FSM). Materials and Methods. Thirty patients who were scheduled for surgical treatment for breast cancer and 10 normal volunteers were enrolled. All 30 patients underwent surgical treatment, and breast cancer was proved histopathologically. Twenty-eight patients had 35 invasive carcinomas, and the remaining two had ductal carcinomas in situ. Each of the 40 women underwent both DRCRM and FSM (with double exposure and the same view, without removing compression). Three observers retrospectively interpreted the mammograms independently and evaluated and rated masses and class categories. The accuracy of the detection of masses was evaluated with alternative free-response receiver-operating characteristic analysis. Sensitivity for the detection of masses and of cancers was also evaluated. Results. The mean areas under the alternative free-response receiver-operating characteristic curves in the detection of the masses were 0.88 for DRCRM and 0.91 for FSM (P = .08). The corresponding values for mean sensitivity for the detection of masses were 0.74 and 0.77 (P = .48) and those for the detection of cancers 0.79 and 0.84 (P = .20). Conclusion. No significant differences were observed between DRCRM and FSM for diagnosis of breast cancers.
    ELSEVIER SCIENCE INC, 2009年07月, ACADEMIC RADIOLOGY, 16(7) (7), 836 - 841, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masahiro Okada, Taro Shimono, Yoshihiro Komeya, Rina Ando, Yuki Kagawa, Takashi Katsube, Masatomo Kuwabara, Yukinobu Yagyu, Seishi Kumano, Izumi Imaoka, Norio Tsuchiya, Ryuichiro Ashikaga, Makoto Hosono, Takamichi Murakami
    To investigate whether integrated fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) can differentiate benign from adrenal malignant lesions on the basis of maximum standardized uptake value (SUV(max)), tumor/liver (T/L) SUV(max) ratio, and CT attenuation value (Hounsfield Units; HU) of unenhanced CT obtained from FDG-PET/CT data. We studied 30 patients with 35 adrenal lesions (16 adrenal benign lesions, size 16 +/- A 5 mm, in 15 patients; and 19 adrenal malignant lesions, 24 +/- A 12 mm, in 15 patients) who had confirmed primary malignancies (lung cancer in 23 patients, lymphoma in 2, esophageal cancer in 2, hypopharyngeal cancer in 1, prostate cancer in 1, and 1 patient in whom lesions were detected at cancer screening). All patients underwent PET/CT at 1 h post FDG injection. Diagnosis of adrenal malignant lesions was based on interval growth or reduction after chemotherapy. An adrenal mass that remained unchanged for over 1 year was the standard used to diagnose adrenal benign lesions. Values of FDG uptake and CT attenuation were measured by placing volumetric regions of interest over PET/CT images. Adrenal uptake of SUV(max) a parts per thousand yen 2.5 was considered to indicate a malignant lesion; SUV(max) < 2.5 was considered to indicate a benign lesion. In further analysis, 1.8 was employed as the threshold for the T/L SUV(max) ratio. Unenhanced CT obtained from PET/CT data was considered positive for adrenal malignant lesions based on a CT attenuation value a parts per thousand yen 10 HU; lesions with a value < 10 HU were considered adrenal benign lesions. Mann-Whitney's U test was used for statistical analyses. SUV(max) in adrenal malignant lesions (7.4 +/- A 3.5) was higher than that in adrenal benign lesions (2.1 +/- A 0.5, p < 0.05). The CT attenuation value of adrenal malignant lesions (27.6 +/- A 11.9 HU) was higher than that of adrenal benign lesions (10.1 +/- A 12.3 HU, p < 0.05). In differentiating between adrenal benign and malignant lesions, a CT threshold of 10 HU corresponded to a sensitivity of 57%, specificity of 94%, accuracy of 74%, positive predictive value of 92% and negative predictive value of 65%. An SUV(max) cut-off value of 2.5 corresponded to a sensitivity of 89%, specificity of 94%, accuracy of 91%, positive predictive value of 94% and negative predictive value of 88%. The T/L SUV(max) ratio was 1.0 +/- A 0.2 for adrenal benign lesions and 4.5 +/- A 3.0 for adrenal malignant lesions. And T/L SUV(max) ratio cut-off value of 1.8 corresponded to a sensitivity of 85%, specificity of 100%, accuracy of 91%, positive predictive value of 100% and negative predictive value of 83%. FDG-PET/CT with additional SUV(max) analysis improves the diagnostic accuracy of adrenal lesions in cancer patients.
    SPRINGER, 2009年06月, ANNALS OF NUCLEAR MEDICINE, 23(4) (4), 349 - 354, 英語
    研究論文（学術雑誌）

  • Masahiro Okada, Taro Shimono, Yoshihiro Komeya, Rina Ando, Yuki Kagawa, Takashi Katsube, Masatomo Kuwabara, Yukinobu Yagyu, Seishi Kumano, Izumi Imaoka, Norio Tsuchiya, Ryuichiro Ashikaga, Makoto Hosono, Takamichi Murakami
    To investigate whether integrated fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) can differentiate benign from adrenal malignant lesions on the basis of maximum standardized uptake value (SUV(max)), tumor/liver (T/L) SUV(max) ratio, and CT attenuation value (Hounsfield Units; HU) of unenhanced CT obtained from FDG-PET/CT data. We studied 30 patients with 35 adrenal lesions (16 adrenal benign lesions, size 16 +/- A 5 mm, in 15 patients; and 19 adrenal malignant lesions, 24 +/- A 12 mm, in 15 patients) who had confirmed primary malignancies (lung cancer in 23 patients, lymphoma in 2, esophageal cancer in 2, hypopharyngeal cancer in 1, prostate cancer in 1, and 1 patient in whom lesions were detected at cancer screening). All patients underwent PET/CT at 1 h post FDG injection. Diagnosis of adrenal malignant lesions was based on interval growth or reduction after chemotherapy. An adrenal mass that remained unchanged for over 1 year was the standard used to diagnose adrenal benign lesions. Values of FDG uptake and CT attenuation were measured by placing volumetric regions of interest over PET/CT images. Adrenal uptake of SUV(max) a parts per thousand yen 2.5 was considered to indicate a malignant lesion; SUV(max) < 2.5 was considered to indicate a benign lesion. In further analysis, 1.8 was employed as the threshold for the T/L SUV(max) ratio. Unenhanced CT obtained from PET/CT data was considered positive for adrenal malignant lesions based on a CT attenuation value a parts per thousand yen 10 HU; lesions with a value < 10 HU were considered adrenal benign lesions. Mann-Whitney's U test was used for statistical analyses. SUV(max) in adrenal malignant lesions (7.4 +/- A 3.5) was higher than that in adrenal benign lesions (2.1 +/- A 0.5, p < 0.05). The CT attenuation value of adrenal malignant lesions (27.6 +/- A 11.9 HU) was higher than that of adrenal benign lesions (10.1 +/- A 12.3 HU, p < 0.05). In differentiating between adrenal benign and malignant lesions, a CT threshold of 10 HU corresponded to a sensitivity of 57%, specificity of 94%, accuracy of 74%, positive predictive value of 92% and negative predictive value of 65%. An SUV(max) cut-off value of 2.5 corresponded to a sensitivity of 89%, specificity of 94%, accuracy of 91%, positive predictive value of 94% and negative predictive value of 88%. The T/L SUV(max) ratio was 1.0 +/- A 0.2 for adrenal benign lesions and 4.5 +/- A 3.0 for adrenal malignant lesions. And T/L SUV(max) ratio cut-off value of 1.8 corresponded to a sensitivity of 85%, specificity of 100%, accuracy of 91%, positive predictive value of 100% and negative predictive value of 83%. FDG-PET/CT with additional SUV(max) analysis improves the diagnostic accuracy of adrenal lesions in cancer patients.
    SPRINGER, 2009年06月, ANNALS OF NUCLEAR MEDICINE, 23(4) (4), 349 - 354, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tatsushige Iwamoto, Yoshihiro Takasugi, Kenji Hiramatsu, Yoshihisa Koga, Tatsuo Konishi, Kensuke Kozuka, Takamichi Murakami
    The incidence of a tracheal bronchus-that is, a congenitally abnormal bronchus originating from the trachea or main bronchi-is 0.1%-2%. Serious hypoxia and atelectasis can develop in such patients with intubation and one-lung ventilation. We experienced a remarkable decrease in peripheral oxygen saturation (Sp(O2)) and a rise in airway pressure during placement of a double-lumen endobronchial tube in a patient with patent ductus arteriosus and tracheal bronchus. Substitution of the double-lumen tube with a bronchial blocker tube provided secure isolation of the lung intraoperatively. A type I tracheal bronchus and segmental tracheal stenosis were identified on postoperative three-dimensional (3D) computed tomographic (CT) images. Preoperative examination of chest X-rays, CT images, and preoperative tracheal 3D images should preempt such complications and assist in securing safe and optimal one-lung ventilation.
    SPRINGER JAPAN KK, 2009年05月, JOURNAL OF ANESTHESIA, 23(2) (2), 260 - 265, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masatoshi Hori, Tonsok Kim, Takamichi Murakami, Izumi Imaoka, Hiromitsu Onishi, Kaname Tomoda, Tateki Tsutsui, Takayuki Enomoto, Tadashi Kimura, Hironobu Nakamura
    Purpose: To prospectively evaluate the efficacy of 3.0-T magnetic resonance (MR) imaging in the preoperative staging of cervical carcinoma compared with that at 1.5-T imaging, with surgery and pathologic analysis as the reference standards. Materials and Methods: Institutional review board approval and informed consent were obtained. Thirty-one consecutive patients (age range, 27-71 years; mean age, 51.1 years) underwent 3.0-and 1.5-T MR imaging. Quantitative and qualitative analyses were performed. Two radiologists independently evaluated images in terms of local-regional staging. MR findings were compared with surgicopathologic findings. Results: Mean tumor signal-to-noise ratios, mean cervical stroma signal-to-noise ratios, and mean tumor-to-cervical stroma contrast-to-noise ratios at 3.0-T imaging were significantly higher than those at 1.5-T imaging (P = 9.1 x 10(-6), P = 1.8 x 10(-6), and P = .008, respectively). Image homogeneity at 3.0-T imaging was significantly inferior to that at 1.5-T imaging (P = .005). There were no significant differences in terms of the degree of susceptibility artifacts. Interobserver agreement between the two radiologists for local-regional staging was good or excellent (kappa = 0.65-0.89). Sensitivity, specificity, and area under the receiver operating characteristic curve for radiologist 1 in the evaluation of parametrial invasion were (a) 75% for both 3.0-and 1.5-T imaging, (b) 70% for both 3.0-and 1.5-T imaging, and (c) 0.82 for 3.0-T imaging and 0.85 for 1.5-T imaging, respectively. Corresponding values for vaginal invasion were (a) 67% for both 3.0-and 1.5-T imaging, (b) 68% for 3.0-T imaging and 72% for 1.5-T imaging, and (c) 0.62 for 3.0-T imaging and 0.67 for 1.5-T imaging, respectively. Corresponding values for lymph node metastases were (a) 57% for both 3.0-and 1.5-T imaging, (b) 83% for 3.0-T imaging and 88% for 1.5-T imaging, and (c) 0.72 for 3.0-T imaging and 0.78 for 1.5-T imaging, respectively. Neither radiologist noted significant differences between values obtained with 3.0-T imaging and those obtained with 1.5-T imaging (P > .5 for all comparison pairs). Conclusion: In this study, 3.0-T MR imaging was characterized by high diagnostic accuracy in the presurgical evaluation of patients with cervical carcinoma, although 3.0-T imaging was not significantly superior to 1.5-T imaging. (c) RSNA, 2009
    RADIOLOGICAL SOC NORTH AMERICA, 2009年04月, RADIOLOGY, 251(1) (1), 96 - 104, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Taro Shimono, Makoto Hosono, Ryuichiro Ashikaga, Seishi Kumano, Izumi Imaoka, Yukinobu Yagyu, Masahiro Okada, Masatomo Kuwabara, Takamichi Murakami
    We have occasionally seen ring-shaped lateral ventricular nodules < 1 cm in diameter during routine brain magnetic resonance imaging (MRI). We investigated retrospectively clinical and MRI findings of the nodules. Review of radiological records was performed for 39,607 patients who underwent brain MRI between January 2001 and April 2008. Nodules were assessed for number, location, shape, and signal intensity, which was determined based on the range of signal intensity from gray to white matter on T1- and T2-weighted imaging. Fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted imaging (DWI), contrast enhancement characteristics, and serial MRI changes of nodules were assessed when available. Nine of 39,607 patients (0.023%) showed the nodules. No symptoms associated with the nodules. Among the nine patients, 11 nodules were identified (one nodule in seven patients (77.8%) and two nodules in two patients (22.2%)). Location was limited to the roof of the body for six nodules (54.5%) and the frontal horn for five patients (45.5%). All nodules (100%) were round and isointense on T1- and T2-weighted imaging. On FLAIR imaging of eight nodules, six (75%) were hyperintense, and two (25%) were isointense. On DWI of seven nodules, all nodules (100%) were isointense. None of seven nodules (0%) examined using postcontrast MRI showed enhancement. None of eight nodules (0%) examined using serial MRI (range, 4-60 months) showed changes in morphology over time. These nodules were incidentally encountered and shared similar MRI features. Although pathological confirmation was lacking in our cases, these nodules may be of nonaggressive nature.
    SPRINGER, 2009年03月, NEURORADIOLOGY, 51(3) (3), 145 - 150, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tonsok Kim, Takamichi Murakami, Masatoshi Hori, Hiromitsu Onishi, Kaname Tomoda, Hironobu Nakamura
    Purpose: To compare 3.0T and 1.5T MR systems in terms of the effect of superparamagnetic iron oxide (SPIO) on tumor-to-liver contrast in 12*-weighted gradient-echo MRI. Materials and Methods: SPIO-enhanced gradient-echo MR images of the liver with four different TEs (3, 5.3, 6.5, and 8.5 msec) were obtained by means of 1.5T and 3.0T systems. Quantitative analyses of relative signal intensities (SIs) and relative tumor contrast and qualitative analyses of image quality and lesion conspicuity of the liver were performed in 22 patients, 16 of whom had malignant liver tumors. Results: With both 1.5T and 3.0T, at TE = 8.4 msec, the relative SI of liver and relative tumor contrast were significantly (P < 0. 0 1) lower and higher, respectively. than that for any of the other TEs. There were no significant differences in the relative SI of the liver, relative tumor contrast, image quality, and tumor conspicuity for the same TE between the 1.5T and 3.0T systems. Conclusion: Our results showed that the effect of SPIO on tumor-to-liver contrast at T2*-weighted gradient-echo imaging was similar for the 1.5T and 3.0T systems, and that the 8.4-msec TE was optimal of the four TEs used in this study at 3.0T.
    JOHN WILEY & SONS INC, 2009年03月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 29(3) (3), 595 - 600, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 勝部 敬, 下野太郎, 村上卓道
    小脳萎縮を呈したNeuroacanthocytosisの兄弟例を報告した。
    AMER SOC NEURORADIOLOGY, 2009年02月, AJNR Am J Neuroradiol, 30(2) (2), 386 - 388, 英語
    研究論文（学術雑誌）

  • Recovery Coefficient(RC)-SUV部分容積効果補正による肺癌リンパ節転移の評価
    米矢 吉宏, 細野 眞, 花岡 宏平, 宇佐美 公男, 高田 裕史, 坂口 健太, 岡田 真広, 土屋 典生, 香川 祐毅, 村上 卓道
    (公社)日本医学放射線学会, 2009年02月, 日本医学放射線学会学術集会抄録集, 68回, S318 - S318, 日本語

  • 非造影の3テスラMRIにおける肝悪性腫瘍の検出能 1.5テスラMRIとの比較
    大西 裕満, 金 東石, 堀 雅敏, 村上 卓道, 巽 光朗, 中矢 泰裕, 中本 篤, 坪山 尚寛, 友田 要, 中村 仁信
    (公社)日本医学放射線学会, 2009年02月, 日本医学放射線学会学術集会抄録集, 68回, S344 - S344, 日本語
    [査読有り]

  • 多段階発癌・早期肝細胞癌の画像診断と病理・病態-c.MRI・SPIP造影MRI-
    熊野正士, 村上卓道, 今井康陽
    2009年, 画像診断, 29(6) (6), 584 - 590

  • Gd-EOB-DTPAの登場による肝画像診断におけるMRIの役割と可能性
    岡田真広, 熊野正士, 香川祐毅, 勝部 敬, 今岡いずみ, 工藤正俊, 村上卓道, 今井康陽
    2009年, 日獨医報, 54, 80 - 93

  • RFA治療後の肝細胞癌再発症例
    村上卓道, 岡田真広, 中居卓也, 工藤正俊
    2009年, EOB-PrimovistR Enhanced MRI Practical Report EOB-PrimovistR Enhanced MRI Practical Report, 1, 1 - 4

  • 熊野正士, 柳生行伸, 村上卓道
    2009年, 肝胆膵画像, 11, 63 - 68

  • MRI T2強調像にて低信号を呈した卵巣粘液嚢胞腺癌の1例
    桑原雅知, 今岡いずみ, 村上卓道
    2009年, 画像診断アトラス, 14, 72 - 73

  • 村上卓道, 岡田真広, 熊野正士
    2009年, 肝胆膵画像, 11(5) (5), 539 - 551

  • 新しい早期肝細胞がんの診断法－Gd-EOB-DTPA造影MRI
    今井康陽, 岡田真広, 村上卓道
    2009年, 日本医師会雑誌, 138(6) (6), 1106

  • 肝癌の診断 肝臓perfusion CT.
    南 康範, 工藤 正俊, 村上 卓道
    2009年, 日本臨床, 67, 342 - 345

  • MDCTは肝癌の診断に有用か？
    熊野正士, 村上卓道
    中外医学社, 2009年, 現場の疑問に答える 肝臓病診療Q＆A, 202 - 205

  • 肝臓：肝臓の画像診断
    岡田真広, 村上卓道, 沼田和司
    2009年, Annual Review 消化器

  • 大西裕満, 村上 卓道, 金東石
    Purpose: To prospectively investigate, by means of a pre-and postexamination questionnaire, the types and frequency of adverse reactions to ferucarbotran (Resovist), a superparamagnetic iron oxide (SPIO) contrast agent. Materials and Methods: This study was approved by the ethics committee of each of the institutions involved, and all patients gave written informed consent. One questionnaire asking about baseline symptoms before the injection of ferucarbotran, and one about adverse events over a period of seven days after injection were given to 315 patients who under-went ferucarbotran-enhanced magnetic resonance imaging (MRI) of the liver at several institutions. The data for baseline symptoms were used for reference to exclude false-positive adverse reactions and were also compared with the adverse event data to determine with McNemar's chi-squared test the incidence of each symptom. Results: Before MR examination, 249 clinical symptoms were reported by 102 of 315 patients (32.4%). After the injection of ferucarbotran, 169 adverse events were observed in 78 patients (24.8%). Eventually, 70 adverse events occurring in 45 patients (14.3%) were judged to be adverse reactions to ferucarbotran, defined as possibly or definitely ferucarbotran -related events. All reactions were of mild intensity. Conclusion: Ferucarbotran can be considered safe for clinical use in liver MRI.
    JOHN WILEY & SONS INC, 2009年01月, JOURNAL OF MAGNETIC RESONANCE IMAGING(in press)., 29(1) (1), 106 - 111, 英語
    研究論文（学術雑誌）

  • Hiromitsu Onishi, Takamichi Murakami, Tonsok Kim, Masatoshi Hori, Shinji Hirohashi, Mitsuru Matsuki, Yoshifumi Narumi, Yasuharu Imai, Kousuke Sakurai, Hironobu Nakamura
    Purpose: To prospectively investigate, by means of a pre-and postexamination questionnaire, the types and frequency of adverse reactions to ferucarbotran (Resovist), a superparamagnetic iron oxide (SPIO) contrast agent. Materials and Methods: This study was approved by the ethics committee of each of the institutions involved, and all patients gave written informed consent. One questionnaire asking about baseline symptoms before the injection of ferucarbotran, and one about adverse events over a period of seven days after injection were given to 315 patients who under-went ferucarbotran-enhanced magnetic resonance imaging (MRI) of the liver at several institutions. The data for baseline symptoms were used for reference to exclude false-positive adverse reactions and were also compared with the adverse event data to determine with McNemar's chi-squared test the incidence of each symptom. Results: Before MR examination, 249 clinical symptoms were reported by 102 of 315 patients (32.4%). After the injection of ferucarbotran, 169 adverse events were observed in 78 patients (24.8%). Eventually, 70 adverse events occurring in 45 patients (14.3%) were judged to be adverse reactions to ferucarbotran, defined as possibly or definitely ferucarbotran -related events. All reactions were of mild intensity. Conclusion: Ferucarbotran can be considered safe for clinical use in liver MRI.
    JOHN WILEY & SONS INC, 2009年01月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 29(1) (1), 106 - 111, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masahiro Okada, Takamichi Murakami, Seishi Kumano, Masatomo Kuwabara, Taro Shimono, Makoto Hosono, Hitoshi Shiozaki
    To assess whether integrated fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) can improve the diagnostic accuracy of metastatic regional lymph nodes (LNs) in esophageal cancer compared with contrast enhanced CT (CECT). We examined 180 consecutive patients with esophageal cancer by integrated PET/CT between April 2006 and March 2007. Eighteen patients (M:F 14:4) underwent radical esophagectomy after evaluations by PET/CT and CECT of 5-7-mm-thick slices 70-80 s after injection. Regional LNs of esophageal cancer were retrospectively reviewed on CECT images by two blinded evaluators on the basis of the following cutoff sizes: 7 mm for all regional LNs (Protocol A), 10 mm for paratracheal LNs (Protocol B), and 7 mm for others. In addition, the maximum standardized uptake value (SUVmax) on PET/CT was evaluated for positive uptake by LNs. Of 210 LNs excised at surgery, 25 were positive and 185 were negative for metastasis at pathology. The PET/CT images identified 15 true-positive and 184 truenegative LNs, whereas CECT identified 15 true positives and 176 true negatives in Protocol A, and 14 true positives and 180 true negative in Protocol B. The sensitivity, specificity, accuracy, positive, and negative predictive values of PET/CT were respectively 60.0%, 99.5%, 94.8%, 93.8%, and 94.8%, whereas those of CECT were 60.0%, 95.1%, 91.0%, 62.5%, and 94.6% (Protocol A) and 56.0%, 97.3%, 92.4%, 73.7%, and 94.2% (Protocol B). A comparison of the two CECT protocols revealed fewer false-positive LNs in Protocol B, but slightly lower sensitivity in Protocol B than in Protocol A. Substantial numbers of false-positive LNs were determined by CECT in the paratracheal regions (6 of 9, 66.7%) and CECT revealed central necrosis in 4 of 15 (26.7%) true-positive LNs > 1.8 cm. The mean SUVmax on PET/CT was 2.9 (range 1.7-5.5) in true-positive LNs. The smallest LN metastasis detectable by PET/CT was 6 mm. Integrated PET/CT improves the PPV of regional LNs when compared with CECT.
    SPRINGER, 2009年01月, ANNALS OF NUCLEAR MEDICINE, 23(1) (1), 73 - 80, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 米矢 吉宏, 細野 眞, 花岡 宏平, 宇佐美 公男, 高田 裕史, 坂口 健太, 岡田 真広, 土屋 典生, 香川 祐毅, 任 誠雲, 村上 卓道
    (一社)日本核医学会, 2008年09月, 核医学, 45(3) (3), S205 - S205, 日本語

  • OOKP(歯根部利用人工角膜)手術後のCT像
    桑原 雅知, 下野 太郎, 勝部 敬, 藤谷 哲也, 松久保 祐子, 足利 竜一朗, 細野 眞, 村上 卓道, 福田 昌彦, 濱田 傑
    (公社)日本医学放射線学会, 2008年09月, 日本医学放射線学会秋季臨床大会抄録集, 44回, S500 - S500, 日本語

  • Masatomo Kuwabara, Taro Shimono, Mami Toyomasu, Mitsuaki Shioyama, Yoshiyuki Mitsui, Eiji Yoshinaga, Akira Kawada, Makoto Hosono, Takamichi Murakami, Susumu Kusunoki
    Relapsing polychondritis is a rare autoimmune disease characterized by recurrent inflammation of cartilage in multiple sites of the body, including the auricles. Central nervous system involvement appears rare. We encountered a case of relapsing polychondritis with encephalitis that could be diagnosed by the unique appearance of the auricle with signal hyperintensity on diffusion-weighted magnetic resonance imaging.
    SPRINGER, 2008年08月, RADIATION MEDICINE, 26(7) (7), 438 - 441, 英語
    研究論文（学術雑誌）

  • 桑原 雅知, 下野 太郎, 村上 卓道
    Relapsing polychondritis is a rare autoimmune disease characterized by recurrent inflammation of cartilage in multiple sites of the body, including the auricles. Central nervous system involvement appears rare. We encountered a case of relapsing polychondritis with encephalitis that could be diagnosed by the unique appearance of the auricle with signal hyperintensity on diffusion-weighted magnetic resonance imaging.
    SPRINGER, 2008年08月, Radiat Med, 26(7) (7), 438 - 441, 英語
    研究論文（学術雑誌）

  • Masatomo Kuwabara, Taro Shimono, Mami Toyomasu, Mitsuaki Shioyama, Yoshiyuki Mitsui, Eiji Yoshinaga, Akira Kawada, Makoto Hosono, Takamichi Murakami, Susumu Kusunoki
    Relapsing polychondritis is a rare autoimmune disease characterized by recurrent inflammation of cartilage in multiple sites of the body, including the auricles. Central nervous system involvement appears rare. We encountered a case of relapsing polychondritis with encephalitis that could be diagnosed by the unique appearance of the auricle with signal hyperintensity on diffusion-weighted magnetic resonance imaging. © 2008 Japan Radiological Society.
    7, 2008年08月, Radiation Medicine - Medical Imaging and Radiation Oncology, 26(7) (7), 438 - 441, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Teruaki Yoh, Makoto Hosono, Yoshihiro Komeya, Sung-Woon Im, Ryuichiro Ashikaga, Taro Shimono, Norio Tsuchiya, Masahiro Okada, Kazushi Hanada, Yukinobu Yagyu, Yasumasa Nishimura, Takamichi Murakami
    Objective The objective of our study was to evaluate diagnostic ability and features of quantitative indices of three modalities: uptake rate on norcholesterol scintigraphy, computed tomography (CT) attenuation value, and fat suppression on chemical-shift magnetic resonance imaging (MRI) for characterizing adrenal adenomas. Methods Image findings of norcholesterol scintigraphy, CT, and MRI were reviewed for 78 patients with functioning (n = 48) or nonfunctioning (n = 30) adrenal masses. The norcholesterol uptake rate, attenuation value on unenhanced CT, and suppression on in-phase to opposed-phase MRI were measured for adrenal masses. Results The norcholesterol uptake rate, CT attenuation value, and MR suppression index showed the sensitivity of 60%, 82%, and 100%, respectively, for functioning adenomas of < 2.0 cm, and 96%, 79%, and 67%, respectively, for those of >= 2.0 cm. A statistically significant correlation was observed between size and norcholesterol uptake, and between CT attenuation value and MR suppression index. Regarding norcholesterol uptake, the adenoma-to-contralateral gland ratio was significantly higher in cortisol releasing than in aldosterone-releasing adenomas. Conclusions The norcholesterol uptake rate was reliable for characterization of adenomas among adrenal masses of >= 2.0 cm. CT attenuation value and MR suppression index were well correlated with each other, and were useful regardless of mass size.
    SPRINGER, 2008年07月, ANNALS OF NUCLEAR MEDICINE, 22(6) (6), 513 - 519, 英語
    研究論文（学術雑誌）

  • Teruaki Yoh, Makoto Hosono, Yoshihiro Komeya, Sung-Woon Im, Ryuichiro Ashikaga, Taro Shimono, Norio Tsuchiya, Masahiro Okada, Kazushi Hanada, Yukinobu Yagyu, Yasumasa Nishimura, Takamichi Murakami
    Objective The objective of our study was to evaluate diagnostic ability and features of quantitative indices of three modalities: uptake rate on norcholesterol scintigraphy, computed tomography (CT) attenuation value, and fat suppression on chemical-shift magnetic resonance imaging (MRI) for characterizing adrenal adenomas. Methods Image findings of norcholesterol scintigraphy, CT, and MRI were reviewed for 78 patients with functioning (n = 48) or nonfunctioning (n = 30) adrenal masses. The norcholesterol uptake rate, attenuation value on unenhanced CT, and suppression on in-phase to opposed-phase MRI were measured for adrenal masses. Results The norcholesterol uptake rate, CT attenuation value, and MR suppression index showed the sensitivity of 60%, 82%, and 100%, respectively, for functioning adenomas of < 2.0 cm, and 96%, 79%, and 67%, respectively, for those of >= 2.0 cm. A statistically significant correlation was observed between size and norcholesterol uptake, and between CT attenuation value and MR suppression index. Regarding norcholesterol uptake, the adenoma-to-contralateral gland ratio was significantly higher in cortisol releasing than in aldosterone-releasing adenomas. Conclusions The norcholesterol uptake rate was reliable for characterization of adenomas among adrenal masses of >= 2.0 cm. CT attenuation value and MR suppression index were well correlated with each other, and were useful regardless of mass size.
    SPRINGER, 2008年07月, ANNALS OF NUCLEAR MEDICINE, 22(6) (6), 513 - 519, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masahiro Okada, Takamichi Murakami, Seishi Kumano, Izumi Imaoka, Taro Shimono, Ryuichiro Ashikaga, Makoto Hosono
    OBJECTIVE. The purpose of our study was to evaluate whether simultaneous injection into cubital veins bilaterally at one half of the standard injection rate achieves similar hepatic and aortic enhancement on MDCT as the conventional injection rate into a single cubital vein. MATERIALS AND METHODS. Thirty-two patients underwent multiphase MDCT because they were suspected of having a hepatic tumor. Patients were assigned to one of the following two groups: group A, 100 mL of 370 mg I/mL of contrast medium injected into a unilateral cubital vein (one-route) via a 20-gauge cannula at a rate of 4 mL/s; or group B, 50 mL of contrast medium injected into the cubital veins bilaterally (two-route) via 24-gauge cannulas at 2 mL/s. Peak contrast enhancement of the liver and abdominal aorta for groups A and B was measured using regions of interest and compared; arrival time of the contrast media was also compared using a bolus-tracking system. Analysis was performed using Wilcoxon's signed rank test. RESULTS. Peak aortic enhancement of groups A and B was 367 +/- 67 H and 361 +/- 113 H (p = 0.61, not significant), respectively, and peak hepatic enhancement of groups A and B was 56 +/- 11 H and 56 +/- 16 H (p = 0.88, not significant), respectively. Mean arrival time to the aorta of group B (19.4 +/- 3.4 seconds) was significantly later compared with that of group A (15.5 +/- 3.5 seconds) (p = 0.005). CONCLUSION. The slower two-route injection produced the same aortic and hepatic enhancement as the faster one-route method with faster injection, but the arrival time of the contrast medium was later using the two-route method.
    AMER ROENTGEN RAY SOC, 2008年06月, AMERICAN JOURNAL OF ROENTGENOLOGY, 190(6) (6), W323 - W326, 英語
    研究論文（学術雑誌）

  • Takatoshi Kitada, Takamichi Murakami, Noriyoshi Kuzushita, Kaori Minamitani, Kazuya Nakajo, Keigo Osuga, Eiji Miyoshi, Hironobu Nakamura, Bunichiro Kishino, Shinji Tamura, Norio Hayashi
    Aim: Real-time virtual sonography (RVS) can synchronize B-mode ultrasound (US) images with multiplanar reconstruction (MPR)-computed tomography (CT) images on the same screen in real time. The purpose of this study was to evaluate the effectiveness of RVS for radiofrequency ablation therapy (RFA) of hepatocellular carcinomas (HCC) in which it was difficult to identify contours or margins by B-mode US. Methods: Sixty-three consecutive patients with a solitary HCC of less than 3.5 cm in diameter were enrolled in this study. Thirty-nine patients with HCC clearly detectable by B-mode US underwent conventional RFA, while the remaining 24 with obscure tumor lesions underwent RVS-guided RFA. A follow-up study of RFA treatment was performed every 3 months using enhanced CT imaging of the arterial and portal phase (at least 24 months). The accuracy of needle insertion was confirmed by measuring the gap between the needle insertion line and the center of the tumor from MPR-CT images. Results: The local recurrence rate of the RVS-guided RFA group was similar to that of the conventional RFA group (8.3% vs 7.7%), despite the difficulty of detecting tumor lesions in the former group. The mean gap between the needle insertion line and the center of the tumor was 1.6 mm (0-3.2 mm) in eight patients treated with RVS-guided RFA. Conclusion: RVS-guided RFA can be useful for treating HCC that are difficult to detect by B-mode US.
    WILEY-BLACKWELL, 2008年06月, HEPATOLOGY RESEARCH, 38(6) (6), 565 - 571, 英語
    研究論文（学術雑誌）

  • 無水エタノールによる腎動脈塞栓術が著効した低形成腎による腎性高血圧の1女児例
    田端信忠, 伊豆亜加音, 井上智弘, 岡田 満, 篠原 徹, 任 誠雲, 坪山尚寛, 栁生行伸, 村上卓道, 竹村 司
    腎低形成による腎性高血圧に対して、腎機能廃絶を目的とした無水エタノールによる腎動脈塞栓術を実施したが、開腹することなく低侵襲的であり、腎摘除術に比する効果が得られた。症例の適応条件を充分に考慮することで、腎摘除術に代わる治療法であると考えられた。
    2008年06月, 小児高血圧研究会誌, 5(1) (1)

  • Takatoshi Kitada, Takamichi Murakami, Noriyoshi Kuzushita, Kaori Minamitani, Kazuya Nakajo, Keigo Osuga, Eiji Miyoshi, Hironobu Nakamura, Bunichiro Kishino, Shinji Tamura, Norio Hayashi
    Aim: Real-time virtual sonography (RVS) can synchronize B-mode ultrasound (US) images with multiplanar reconstruction (MPR)-computed tomography (CT) images on the same screen in real time. The purpose of this study was to evaluate the effectiveness of RVS for radiofrequency ablation therapy (RFA) of hepatocellular carcinomas (HCC) in which it was difficult to identify contours or margins by B-mode US. Methods: Sixty-three consecutive patients with a solitary HCC of less than 3.5 cm in diameter were enrolled in this study. Thirty-nine patients with HCC clearly detectable by B-mode US underwent conventional RFA, while the remaining 24 with obscure tumor lesions underwent RVS-guided RFA. A follow-up study of RFA treatment was performed every 3 months using enhanced CT imaging of the arterial and portal phase (at least 24 months). The accuracy of needle insertion was confirmed by measuring the gap between the needle insertion line and the center of the tumor from MPR-CT images. Results: The local recurrence rate of the RVS-guided RFA group was similar to that of the conventional RFA group (8.3% vs 7.7%), despite the difficulty of detecting tumor lesions in the former group. The mean gap between the needle insertion line and the center of the tumor was 1.6 mm (0-3.2 mm) in eight patients treated with RVS-guided RFA. Conclusion: RVS-guided RFA can be useful for treating HCC that are difficult to detect by B-mode US.
    WILEY-BLACKWELL, 2008年06月, HEPATOLOGY RESEARCH, 38(6) (6), 565 - 571, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masahiro Okada, Takamichi Murakami, Seishi Kumano, Izumi Imaoka, Taro Shimono, Ryuichiro Ashikaga, Makoto Hosono
    OBJECTIVE. The purpose of our study was to evaluate whether simultaneous injection into cubital veins bilaterally at one half of the standard injection rate achieves similar hepatic and aortic enhancement on MDCT as the conventional injection rate into a single cubital vein. MATERIALS AND METHODS. Thirty-two patients underwent multiphase MDCT because they were suspected of having a hepatic tumor. Patients were assigned to one of the following two groups: group A, 100 mL of 370 mg I/mL of contrast medium injected into a unilateral cubital vein (one-route) via a 20-gauge cannula at a rate of 4 mL/s; or group B, 50 mL of contrast medium injected into the cubital veins bilaterally (two-route) via 24-gauge cannulas at 2 mL/s. Peak contrast enhancement of the liver and abdominal aorta for groups A and B was measured using regions of interest and compared; arrival time of the contrast media was also compared using a bolus-tracking system. Analysis was performed using Wilcoxon's signed rank test. RESULTS. Peak aortic enhancement of groups A and B was 367 +/- 67 H and 361 +/- 113 H (p = 0.61, not significant), respectively, and peak hepatic enhancement of groups A and B was 56 +/- 11 H and 56 +/- 16 H (p = 0.88, not significant), respectively. Mean arrival time to the aorta of group B (19.4 +/- 3.4 seconds) was significantly later compared with that of group A (15.5 +/- 3.5 seconds) (p = 0.005). CONCLUSION. The slower two-route injection produced the same aortic and hepatic enhancement as the faster one-route method with faster injection, but the arrival time of the contrast medium was later using the two-route method.
    AMER ROENTGEN RAY SOC, 2008年06月, AMERICAN JOURNAL OF ROENTGENOLOGY, 190(6) (6), W323 - W326, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 香川 祐毅, 細野 眞, 米矢 吉宏, 岡田 真広, 土屋 典生, 花岡 宏平, 宇佐美 公男, 高田 裕史, 坂口 健太, 葉 輝明, 任 誠雲, 柳生 行伸, 足利 竜一朗, 村上 卓道
    ファントム実験で得られた回復係数(RCs)を用い、部分容積効果の影響を受けやすいリンパ節のStandardized uptake values(SUV)補正を行うことで、肺癌および食道癌での縦隔リンパ節転移の診断能が向上するか検討した。肺癌においても食道癌においても、リンパ節転移の診断には、ROC解析でsizeよりもSUVmaxとcSUVmaxでの評価の方が大きなAzを示し、高い診断能を有した。SUVmaxとcSUVmaxの比較では、補正によりAzがやや低下し、小病変の低いSUVmaxが過大に補正されて診断能を損なった可能性があった。食道癌の転移陽性リンパ節は肺癌の転移陽性リンパ節に比してsizeが小さく、SUVmaxが低い傾向があり、腫瘍ごとにリンパ節転移のsize、SUVmaxについて指標を設定する必要が考えられた。
    産業開発機構(株), 2008年06月, 映像情報Medical, 40(6) (6), 618 - 619, 日本語

  • Koji Mikami, Takamichi Murakami, Atsuya Okada, Keigo Osuga, Kaname Tomoda, Hironobu Nakamura
    Purpose. The aim of this study was to assess the feasibility and effectiveness of magnetic resonance ( MRI)-guided focused ultrasound ( MRIgFUS) ablation for uterine fibroids and to identify the candidates for this treatment. Materials and methods. A total of 48 patients with a symptomatic uterine fibroid underwent MRIgFUS. The percent ablation volume was calculated, and the patients' characteristics and the MR imaging features of the fibroids that might predict the effect of this treatment were assessed. Changes in the symptoms related to the uterine fibroid were assessed at 6 and 12 months. Results. The planned target zone were successfully treated in 32 patients with bulk-related and menstrual symptoms but unsuccessfully treated in the remaining 16 patients. These 16 patients were obese or their uterine fibroid showed heterogeneous high signal intensity on T2-weighted images. The 32 successfully treated patients were followed up for 6 months. At the 6-month follow-up, bulk-related and menstrual symptoms were diminished in 60% and 51% of patients, respectively. Among them, 17 patients were followed up for 12 months, and 9 of them who showed alleviation of bulk-related symptoms at 6 months had further improvement. The mean percent ablation volume of those nine patients was 51%. In 5 ( 33%) of the 15 patients with alleviation of menstrual symptoms at 6 months, the symptoms became worse at 12 months. There was a significant difference in the mean percent ablation volume between patients with alleviation of menstrual symptoms and those without ( 54% vs. 37%; P = 0.03). Conclusion. MRIgFUS ablation is a safe, effective treatment for nonobese patients with symptomatic fibroids that show low signal intensity on T2-weighted images. Ablation of more than 50% of the fibroid volume may be needed with a short-term follow-up.
    SPRINGER, 2008年05月, RADIATION MEDICINE, 26(4) (4), 198 - 205, 英語
    研究論文（学術雑誌）

  • 第7章 治療効果の評価と追加治療：CTによる治療効果評価：
    岡田 真広, 村上 卓道
    中山書店, 2008年05月, 大﨑住夫編 肝癌ラジオ波凝固療法の実践テクニック, 220 - 228

  • 第6章 RFAの新しい展開：HIFU臨床開発の現況
    村上 卓道
    中山書店, 2008年05月, 大﨑住夫編 肝癌ラジオ波凝固療法の実践テクニック, 203

  • Koji Mikami, Takamichi Murakami, Atsuya Okada, Keigo Osuga, Kaname Tomoda, Hironobu Nakamura
    Purpose. The aim of this study was to assess the feasibility and effectiveness of magnetic resonance (MRI)-guided focused ultrasound (MRIgFUS) ablation for uterine fibroids and to identify the candidates for this treatment. Materials and methods. A total of 48 patients with a symptomatic uterine fibroid underwent MRIgFUS. The percent ablation volume was calculated, and the patients' characteristics and the MR imaging features of the fibroids that might predict the effect of this treatment were assessed. Changes in the symptoms related to the uterine fibroid were assessed at 6 and 12 months. Results. The planned target zone were successfully treated in 32 patients with bulk-related and menstrual symptoms but unsuccessfully treated in the remaining 16 patients. These 16 patients were obese or their uterine fibroid showed heterogeneous high signal intensity on T2-weighted images. The 32 successfully treated patients were followed up for 6 months. At the 6-month follow-up, bulk-related and menstrual symptoms were diminished in 60% and 51% of patients, respectively. Among them, 17 patients were followed up for 12 months, and 9 of them who showed alleviation of bulk-related symptoms at 6 months had further improvement. The mean percent ablation volume of those nine patients was 51%. In 5 (33%) of the 15 patients with alleviation of menstrual symptoms at 6 months, the symptoms became worse at 12 months. There was a significant difference in the mean percent ablation volume between patients with alleviation of menstrual symptoms and those without (54% vs. 37% P = 0.03). Conclusion. MRIgFUS ablation is a safe, effective treatment for nonobese patients with symptomatic fibroids that show low signal intensity on T2-weighted images. Ablation of more than 50% of the fibroid volume may be needed with a short-term follow-up. © 2008 Japan Radiological Society.
    4, 2008年05月, Radiation Medicine - Medical Imaging and Radiation Oncology, 26(4) (4), 198 - 205, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hot Spot Tracking for Focused Ultrasound Surgery of Liver using Filtered Venography
    D. Kokuryo, E. Kumamoto, A. Okada, T. Murakami, S. Fujii, T. Kaihara, K. Kuroda
    2008年05月, Proc. 16th ISMRM Scientific Meeting and Exhibition, 1229 - 1229, 英語
    [査読有り]
    研究論文（国際会議プロシーディングス）

  • Taro Shimono, Takahiro Tsuboyama, Masatomo Kuwabara, Sung-woon Im, Yukinobu Yagyu, Izumi Imaoka, Ryuichiro Ashikaga, Makoto Hosono, Takamichi Murakami
    Purpose. Motion artifact is problematic in the diagnosis of Creutzfeldt-Jakob disease (CJD) because of dementia. The purpose was to compare the occurrence of this artifact between a diffusion-weighted (DW) magnetic resonance ( MR) imaging sequence and conventional sequences. Materials and methods. Ten MR examinations comprising T2- weighted, T1- weighted, DW, and fl uidattenuated inversion recovery imaging in seven CJD patients were retrospectively evaluated. The occurrence of motion artifacts on each sequence were assessed, and the examination was classifi ed into four groups as follows: group A, motion artifact not revealed on DW imaging but revealed on one or more other sequences; group B, revealed on DW imaging and one or more other sequences; group C, not revealed on any sequences; and group D, revealed on DW imaging but not on any other sequences. Results. The 10 MR examinations were classifi ed as eight group A ( 80%), one B ( 10%), one C ( 10%), and zero D ( 0%). Conclusion. Motion artifacts are likely to occur in any conventional imaging sequences in CJD, but the fastimaging ability of DW imaging can reduce this artifact. The combination of an absence of motion artifact on DW imaging and the presence on conventional sequences may be one of the frequent fi ndings of CJD.
    SPRINGER, 2008年04月, RADIATION MEDICINE, 26(3) (3), 151 - 155, 英語
    研究論文（学術雑誌）

  • Taro Shimono, Takahiro Tsuboyama, Masatomo Kuwabara, Sung-Woon Im, Yukinobu Yagyu, Izumi Imaoka, Ryuichiro Ashikaga, Makoto Hosono, Takamichi Murakami
    Purpose. Motion artifact is problematic in the diagnosis of Creutzfeldt-Jakob disease (CJD) because of dementia. The purpose was to compare the occurrence of this artifact between a diffusion-weighted (DW) magnetic resonance (MR) imaging sequence and conventional sequences. Materials and methods. Ten MR examinations comprising T2-weighted, T1-weighted, DW, and fluid-attenuated inversion recovery imaging in seven CJD patients were retrospectively evaluated. The occurrence of motion artifacts on each sequence were assessed, and the examination was classified into four groups as follows: group A, motion artifact not revealed on DW imaging but revealed on one or more other sequences group B, revealed on DW imaging and one or more other sequences group C, not revealed on any sequences and group D, revealed on DW imaging but not on any other sequences. Results. The 10 MR examinations were classified as eight group A (80%), one B (10%), one C (10%), and zero D (0%). Conclusion. Motion artifacts are likely to occur in any conventional imaging sequences in CJD, but the fast-imaging ability of DW imaging can reduce this artifact. The combination of an absence of motion artifact on DW imaging and the presence on conventional sequences may be one of the frequent findings of CJD. © 2008 Japan Radiological Society.
    3, 2008年04月, Radiation Medicine - Medical Imaging and Radiation Oncology, 26(3) (3), 151 - 155, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 大動脈解離後に発症した下腸間膜動脈領域の虚血性腸炎
    任 誠雲, 下野 太郎, 柳生 行伸, 清水 利栄, 葉 輝明, 坪山 尚寛, 桑原 雅知, 小塚 健倫, 今岡 いずみ, 足利 竜一朗, 村上 卓道, 米矢 吉宏, 土屋 典生, 岡田 真広, 細野 眞, 井上 剛裕, 梅原 泰, 土手 健作
    (公社)日本医学放射線学会, 2008年04月, Radiation Medicine, 26(Suppl.I) (Suppl.I), 47 - 47, 日本語

  • 卵巣腫瘤との鑑別が困難であった限局性腹膜偽粘液腫の1例
    清水 利栄, 今岡 いずみ, 下野 太郎, 桑原 雅知, 小塚 健倫, 葉 輝明, 任 誠雲, 坪山 尚寛, 柳生 行伸, 熊野 正士, 足利 竜一朗, 村上 卓道, 米矢 吉宏, 土屋 典生, 岡田 真広, 細野 眞
    (公社)日本医学放射線学会, 2008年04月, Radiation Medicine, 26(Suppl.I) (Suppl.I), 50 - 50, 日本語

  • Azzam A. Khankan, Takamichi Murakami, Hiromitsu Onishi, Masaki Matsushita, Riccardo Iannaccone, Yoshiko Aoki, Takeshi Tono, Tonsok Kim, Masatoshi Hori, Keigo Osuga, Roberto Passariello, Hironobu Nakamura
    Purpose: To determine the usefulness of nonenhanced T1-weighted spoiled gradient-recalled acquisition in the steady-state (SPGR) MRI in the early assessment of the efficacy of radio frequency (RF) therapy for hepatocellular carcinoma (HCC). Materials and Methods: A total of 23 patients with 28 HCC nodules treated with percutaneous RF ablation underwent nonenhanced MRI within two days after the RF procedure and contrast-enhanced computed tomography (CT) one week after. MR assessment of ablation efficacy according to the concentric zonal pattern on T1-weighted SPGR imaging was compared with the one-week CT and presence of local recurrence by means of follow-up study for 12 months or more. Results: In 18 of 28 ablated nodules, SPGR images revealed a central hyperintense zone covering the entire tumor, CT showed a nonenhanced area covering the entire tumor, and no local recurrence was demonstrated in the follow-up studies. In nine of 28 nodules, the central hyperintense zone did not cover the entire tumor; and local recurrence was demonstrated in three nodules. In the remaining one nodule, no signal change was seen in the treated area on SPGR images and CT showed the presence of residual viable tumor. Conclusion: Nonenhanced T1-weighted MRI was considered useful for early assessment of the efficacy of RF therapy for HCC.
    JOHN WILEY & SONS INC, 2008年03月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 27(3) (3), 546 - 551, 英語
    研究論文（学術雑誌）

  • Azzam A. Khankan, Takamichi Murakami, Hiromitsu Onishi, Masaki Matsushita, Riccardo Iannaccone, Yoshiko Aoki, Takeshi Tono, Tonsok Kim, Masatoshi Hori, Keigo Osuga, Roberto Passariello, Hironobu Nakamura
    Purpose: To determine the usefulness of nonenhanced T1-weighted spoiled gradient-recalled acquisition in the steady-state (SPGR) MRI in the early assessment of the efficacy of radio frequency (RF) therapy for hepatocellular carcinoma (HCC). Materials and Methods: A total of 23 patients with 28 HCC nodules treated with percutaneous RF ablation underwent nonenhanced MRI within two days after the RF procedure and contrast-enhanced computed tomography (CT) one week after. MR assessment of ablation efficacy according to the concentric zonal pattern on T1-weighted SPGR imaging was compared with the one-week CT and presence of local recurrence by means of follow-up study for 12 months or more. Results: In 18 of 28 ablated nodules, SPGR images revealed a central hyperintense zone covering the entire tumor, CT showed a nonenhanced area covering the entire tumor, and no local recurrence was demonstrated in the follow-up studies. In nine of 28 nodules, the central hyperintense zone did not cover the entire tumor; and local recurrence was demonstrated in three nodules. In the remaining one nodule, no signal change was seen in the treated area on SPGR images and CT showed the presence of residual viable tumor. Conclusion: Nonenhanced T1-weighted MRI was considered useful for early assessment of the efficacy of RF therapy for HCC.
    JOHN WILEY & SONS INC, 2008年03月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 27(3) (3), 546 - 551, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yasuharu Imai, Takamichi Murakami, Masatoshi Hori, Kazuto Fukuda, Tonsok Kim, Taro Marukawa, Hisashi Abe, Masatomo Kuwabara, Hiromitu Onishi, Kyo Tsuda, Yoshiyuki Sawai, Masanori Kurokawa, Norio Hayashi, Morito Monden, Hironobu Nakamura
    Aim: Recently, many diagnostic modalities have been developed for the detection of hepatocellular carcinoma (HCC). Of these, a less invasive and more accurate diagnostic procedure is desirable. This study was undertaken to compare combined dynamic multidetector row helical computerized tomography (MDCT) and superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI) with combined CT hepatic arteriography (CTHA) and CT during arterial portography (CTAP) for the detection of hypervascular HCC. Methods: Forty-eight patients with 56 pathologically proved hypervascular HCCs (less than 5.0 cm in diameter) underwent dynamic MDCT and SPIO-enhanced MRI, as well as CTHA and CTAP. The images were reviewed by four independent and blinded readers on a tumor-by-tumor basis. Results: The mean areas under alternative-free response receiver operating characteristic curve (Az) for combined dynamic MDCT and SPIO-enhanced MRI (IV set) and combinedCTHA and CTAP (IA set) were comparable (0.948 and 0.969, respectively, P > 0.05), although the Az value of the IV set was significantly lower than that of the IA set in HCCs smaller than or equal to 1.5 cm (0.867 and 0.937, respectively, P = 0.033). The mean sensitivity and positive predictive value of the IV set were similar to those of the IA set. Conclusions: Combined dynamic MDCT and SPIO-enhanced MRI showed a diagnostic accuracy comparable to intra-arterial contrast-enhanced CT (CTHA and CTAP) for hypervascular HCC, and may be a useful diagnostic option prior to curative treatments of hypervascular HCC, although a limitation exists in detecting HCCs smaller than or equal to 1.5 cm.
    BLACKWELL PUBLISHING, 2008年02月, HEPATOLOGY RESEARCH, 38(2) (2), 147 - 158, 英語
    研究論文（学術雑誌）

  • Yasuharu Imai, Takamichi Murakami, Masatoshi Hori, Kazuto Fukuda, Tonsok Kim, Taro Marukawa, Hisashi Abe, Masatomo Kuwabara, Hiromitu Onishi, Kyo Tsuda, Yoshiyuki Sawai, Masanori Kurokawa, Norio Hayashi, Morito Monden, Hironobu Nakamura
    Aim: Recently, many diagnostic modalities have been developed for the detection of hepatocellular carcinoma (HCC). Of these, a less invasive and more accurate diagnostic procedure is desirable. This study was undertaken to compare combined dynamic multidetector row helical computerized tomography (MDCT) and superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI) with combined CT hepatic arteriography (CTHA) and CT during arterial portography (CTAP) for the detection of hypervascular HCC. Methods: Forty-eight patients with 56 pathologically proved hypervascular HCCs (less than 5.0 cm in diameter) underwent dynamic MDCT and SPIO-enhanced MRI, as well as CTHA and CTAP. The images were reviewed by four independent and blinded readers on a tumor-by-tumor basis. Results: The mean areas under alternative-free response receiver operating characteristic curve (Az) for combined dynamic MDCT and SPIO-enhanced MRI (IV set) and combinedCTHA and CTAP (IA set) were comparable (0.948 and 0.969, respectively, P > 0.05), although the Az value of the IV set was significantly lower than that of the IA set in HCCs smaller than or equal to 1.5 cm (0.867 and 0.937, respectively, P = 0.033). The mean sensitivity and positive predictive value of the IV set were similar to those of the IA set. Conclusions: Combined dynamic MDCT and SPIO-enhanced MRI showed a diagnostic accuracy comparable to intra-arterial contrast-enhanced CT (CTHA and CTAP) for hypervascular HCC, and may be a useful diagnostic option prior to curative treatments of hypervascular HCC, although a limitation exists in detecting HCCs smaller than or equal to 1.5 cm.
    BLACKWELL PUBLISHING, 2008年02月, HEPATOLOGY RESEARCH, 38(2) (2), 147 - 158, 英語
    [査読有り]
    研究論文（学術雑誌）

  • T2* fitting toolによる子宮筋層と子宮良性病変の評価
    今岡 いずみ, 坪山 尚寛, 柳生 行伸, 下野 太郎, 熊野 正士, 村上 卓道, 奥秋 知幸, 小山 望
    (公社)日本医学放射線学会, 2008年02月, 日本医学放射線学会学術集会抄録集, 67回, S213 - S213, 日本語

  • 原発性肺癌のリンパ節転移の評価におけるrecovery coefficient(RC) SUV補正の有用性
    米矢 吉宏, 細野 眞, 花岡 宏平, 宇佐見 公男, 高田 裕史, 坂口 健太, 岡田 真広, 土屋 典生, 香川 祐毅, 村上 卓道
    (公社)日本医学放射線学会, 2008年02月, 日本医学放射線学会学術集会抄録集, 67回, S376 - S376, 日本語

  • 転移性肝がんの診断【近畿大学医学部附属病院】
    岡田 真広, 熊野 正士, 畑中 絹世, 工藤 正俊, 村上 卓道
    2008年, INNEVISION INNEVISION, 23, 6 - 11

  • 腎癌摘出後14年目に生じた膵転移に対してPET-CTとDynamic CTを施行した1例 腎癌の遠隔転移におけるPET-CTの役割
    松久保祐子, 岡田 真広, 村上 卓道
    2008年, 核医学症例検討会症例集, 29, 15 - 16

  • 岡田 真広, 熊野 正士, 村上 卓道
    2008年, 肝胆膵画像, 10, 25 - 33

  • びまん性肝疾患・脾
    金 東石, 村上 卓道
    メディカルサイエンスインターナショナル, 2008年, 腹部のMRI, 5 - 44

  • 腎癌の遠隔転移におけるPET-CTの役割
    松久保祐子, 岡田 真広, 村上 卓道
    2008年, 核医学症例検討会症例集, 29, 15 - 16

  • 診断に苦慮した上衣腫の2例
    荒木哲朗, 下野 太郎, 村上 卓道
    2008年, 臨床放射線, 53, 1141 - 1145

  • 肝臓ダイナミックCTにおけるイオメプロール350mgl/mLの投与方法および投与量に関する検討（臨床第Ⅱ/Ⅲ相試験）-体重比用量群と固定用量群との多施設共同ランダム化比較試験-
    粟井和夫, 村上 卓道, 山下康行
    2008年, 臨床医薬, 24, 575 - 597

  • 転移性肝がんの診断
    岡田 真広, 熊野 正士, 村上 卓道
    2008年, Innervison Innervison, 23(5) (5), 6 - 11

  • Takahiro Tsuboyama, Izumi Imaoka, Taro Shimono, Takayuki Nakatsuka, Ryuichiro Ashikaga, Tomoyuki Okuaki, Nozomu Koyama, Takamichi Murakami
    Purpose: We evaluated the ability of the PRESTO (principles of echo shifting with a train of observations) technique to reveal small veins and microbleeds in the human brain. Materials and Methods: In an experimental study, we calculated contrast-to-noise ratio (CNR) between a cerebral parenchymal phantom and human venous blood using 3 sequences of 3-dimensional (3D)-PRESTO, 3D-gradient recalled echo (GRE), and 3D-GRE echo-planar imaging (EPI). Then, we examined 7 healthy volunteers and 5 patients with venous angiomas or traumatic brain injuries using the 3D-PRESTO technique. In volunteer studies, MR venographies were reconstructed from 10-mm, 15-mm, and 20-mm thickness data using the minimum-intensity-projection (MinIP) technique. Three radiologists identified deep brain venous anatomy and counted the visible left medullary veins. In clinical studies, we evaluated the lesion conspicuity of small venous diseases and microbleeds. Results: In the phantom study, 3D-PRESTO showed the highest CNR. In all volunteer studies, the deep brain venous anatomy was readily identified in the MinIP images at each thickness. The mean numbers of counted left medullary veins were 5.1 for 10 mm, 5.9 for 15 mm, and 6.7 for 20 mm in the MinIP images. The difference was significant between 10-mm and 20-mm MinIP images (P=0.02). In patient studies, abnormal small veins and microbleeds were clearly revealed. Conclusion: High-resolution MR venography using 3D-PRESTO technique can clearly depict small veins and microbleeds in the human brain.
    2, 2008年, Magnetic Resonance in Medical Sciences, 7(2) (2), 73 - 77, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Motoko Nishiura, Takeshi Johkoh, Shuji Yamamoto, Osamu Honda, Takenori Kozuka, Mitsuhiro Koyama, Noriyuki Tomiyama, Seiki Hamada, Takamichi Murakami, Takashi Matsumoto, Yoshifumi Narumi, Hironobu Nakamura
    Purpose. The aim of this study was to evaluate the decreasing of cardiac motion artifact and whether the extent of ground-glass attenuation of idiopathic pulmonary fibrosis (IPF) was accurately assessed by electrocardiography (ECG)-triggered high-resolution computed tomography (HRCT) by 0.5-s/rotation multidetector-row CT (MDCT). Materials and methods. ECG-triggered HRCT were scanned at the end-diastolic phase by a MDCT scanner with the following scan parameters axial four-slice mode, 0.5 mm collimation, 0.5-s/rotation, 120 kVp, 200 mA/rotation, high-frequency algorithm, and half reconstruction. In 42 patients with IPF, both conventional HRCT (ECG gating(-), full reconstruction) and ECG-triggered HRCT were performed at the same levels (10-mm intervals) with the above scan parameters. The correlation between percent diffusion of carbon monoxide of the lung (%DLCO) and the mean extent of ground-glass attenuation on both conventional HRCT and ECG-triggered HRCT was evaluated with the Spearman rank correlation coefficient test. Results. The correlation between %DLCO and the mean extent of ground-glass attenuation on ECG-triggered HRCT (observer A: r = -0.790, P < 0.0001 observer B: r = -0.710, P < 0.0001) was superior to that on conventional HRCT (observer A: r = -0.395, P < 0.05 observer B: r = -0.577, P = 0.002) for both observers. Conclusion. ECG-triggered HRCT by 0.5 s/rotation MDCT can reduce the cardiac motion artifact and is useful for evaluating the extent of ground-glass attenuation of IPF. © 2007 Japan Radiological Society.
    2007年12月, Radiation Medicine - Medical Imaging and Radiation Oncology, 25(10) (10), 523 - 528, 英語
    研究論文（学術雑誌）

  • Hirokazu Uyama, Hiroaki Nagano, Hideji Nakamura, Takamichi Murakami, Hironobu Nakamura, Morito Monden, Norio Hayashi
    Background: Patients with advanced hepatocellular carcinoma (HCC) need an effective treatment modality because of the poor prognosis of the disease. From an in vitro study, beta-interferon (IFN-beta) has been reported to enhance the antiproliferative effects of doxorubicin on HCC cell lines. In the present study, we investigated the therapeutic effects of combined IFN-beta and doxorubicin intra-arterial injection therapy on patients with advanced HCC. Methods: IFN-beta (3 MIU) and doxorubicin (10 mg/bodyweight) were given by one-shot intra-arterial injection through an arterial port to patients with advanced HCC. One treatment course consisted of three intra-arterial injections per week for 4 weeks. Three courses were conducted and evaluation was done monthly. Results: Eleven patients with advanced HCC were treated with combined IFN-beta and doxorubicin. One patient enteredcomplete remission (CR), seven patients were evaluated as having stable disease (SD) and three as having progressive disease (PD). The mean overall survival was 10 months. The mean survival for CR and SD patients was 15 months, and that for PD patients was 6 months (P = 0.0464, log-rank test). Decrease of serum total bilirubin was observed for all patients. Conclusion: Combined IFN-beta and doxorubicin intra-arterial therapy offers an effective chemotherapy option for patients with advanced HCC by improving liver function and having tolerable side-effects.
    BLACKWELL PUBLISHING, 2007年12月, HEPATOLOGY RESEARCH, 37(12) (12), 1018 - 1025, 英語
    研究論文（学術雑誌）

  • Hirokazu Uyama, Hiroaki Nagano, Hideji Nakamura, Takamichi Murakami, Hironobu Nakamura, Morito Monden, Norio Hayashi
    Background: Patients with advanced hepatocellular carcinoma (HCC) need an effective treatment modality because of the poor prognosis of the disease. From an in vitro study, beta-interferon (IFN-beta) has been reported to enhance the antiproliferative effects of doxorubicin on HCC cell lines. In the present study, we investigated the therapeutic effects of combined IFN-beta and doxorubicin intra-arterial injection therapy on patients with advanced HCC. Methods: IFN-beta (3 MIU) and doxorubicin (10 mg/bodyweight) were given by one-shot intra-arterial injection through an arterial port to patients with advanced HCC. One treatment course consisted of three intra-arterial injections per week for 4 weeks. Three courses were conducted and evaluation was done monthly. Results: Eleven patients with advanced HCC were treated with combined IFN-beta and doxorubicin. One patient enteredcomplete remission (CR), seven patients were evaluated as having stable disease (SD) and three as having progressive disease (PD). The mean overall survival was 10 months. The mean survival for CR and SD patients was 15 months, and that for PD patients was 6 months (P = 0.0464, log-rank test). Decrease of serum total bilirubin was observed for all patients. Conclusion: Combined IFN-beta and doxorubicin intra-arterial therapy offers an effective chemotherapy option for patients with advanced HCC by improving liver function and having tolerable side-effects.
    BLACKWELL PUBLISHING, 2007年12月, HEPATOLOGY RESEARCH, 37(12) (12), 1018 - 1025, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Motoko Nishiura, Takeshi Johkoh, Shuji Yamamoto, Osamu Honda, Takenori Kozuka, Mitsuhiro Koyama, Noriyuki Tomiyama, Seiki Hamada, Takamichi Murakami, Takashi Matsumoto, Yoshifumi Narumi, Hironobu Nakamura
    Purpose. The aim of this study was to evaluate the decreasing of cardiac motion artifact and whether the extent of ground-glass attenuation of idiopathic pulmonary fibrosis (IPF) was accurately assessed by electrocardiography (ECG)-triggered high-resolution computed tomography (HRCT) by 0.5-s/rotation multidetector-row CT (MDCT). Materials and methods. ECG-triggered HRCT were scanned at the end-diastolic phase by a MDCT scanner with the following scan parameters axial four-slice mode, 0.5 mm collimation, 0.5-s/rotation, 120 kVp, 200 mA/rotation, high-frequency algorithm, and half reconstruction. In 42 patients with IPF, both conventional HRCT (ECG gating(-), full reconstruction) and ECG-triggered HRCT were performed at the same levels (10-mm intervals) with the above scan parameters. The correlation between percent diffusion of carbon monoxide of the lung (%DLCO) and the mean extent of ground-glass attenuation on both conventional HRCT and ECG-triggered HRCT was evaluated with the Spearman rank correlation coefficient test. Results. The correlation between %DLCO and the mean extent of ground-glass attenuation on ECG-triggered HRCT (observer A: r = -0.790, P < 0.0001 observer B: r = -0.710, P < 0.0001) was superior to that on conventional HRCT (observer A: r = -0.395, P < 0.05 observer B: r = -0.577, P = 0.002) for both observers. Conclusion. ECG-triggered HRCT by 0.5 s/rotation MDCT can reduce the cardiac motion artifact and is useful for evaluating the extent of ground-glass attenuation of IPF. © 2007 Japan Radiological Society.
    10, 2007年12月, Radiation Medicine - Medical Imaging and Radiation Oncology, 25(10) (10), 523 - 528, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 腎血管性高血圧患者に対して腎動脈塞栓術が著効した1例
    任 誠雲, 柳生 行伸, 桑原 雅知, 坪山 尚寛, 下野 太郎, 清水 利栄, 小塚 健倫, 今岡 いずみ, 熊野 正士, 葉 輝明, 細野 眞, 土屋 典生, 岡田 真広, 米矢 吉宏, 村上 卓道, 竹村 司
    (一社)日本インターベンショナルラジオロジー学会, 2007年10月, IVR: Interventional Radiology, 22(4) (4), 495 - 495, 日本語

  • recovery coefficient(RC)に基づくSUV補正を用いた肺癌リンパ節転移の評価
    米矢 吉宏, 細野 眞, 花岡 宏平, 宇佐見 公男, 高田 裕史, 坂口 健太, 任 誠雲, 土屋 典生, 岡田 真広, 葉 輝明, 村上 卓道
    (一社)日本核医学会, 2007年10月, 核医学, 44(3) (3), 287 - 287, 日本語

  • [Advancement of the imaging for hepatic malignancies].
    Kumano S, Okada M, Imaoka I, Shimono T, Hosono M, Murakami T
    9, 2007年09月, Gan to kagaku ryoho. Cancer & chemotherapy, 34, 1357 - 1360
    [査読有り]

  • Riccardo Iannaccone, Francesca Piacentini, Takamichi Murakami, Valerie Paradis, Jacques Belghiti, Masatoshi Hori, Tonsok Kim, Francois Durand, Kenichi Wakasa, Morito Monden, Hironobu Nakamura, Roberto Passariello, Valerie Vilgrain
    Purpose: To retrospectively evaluate the clinical, pathologic, and helical computed tomographic ( CT) and magnetic resonance ( MR) imaging findings of hepatocellular carcinoma ( HCC) in patients with nonalcoholic fatty liver disease ( NAFLD). Materials and Methods: Institutional review board approval was obtained for this study; the need for patient informed consent was waived. Clinical, pathologic, and imaging findings were retrospectively evaluated in 22 men ( mean age, 64.5 years) with HCC and NAFLD. Helical CT and MR images were reviewed for morphologic features such as tumor size, margins, necrosis, and degree of enhancement. Results: Obesity, diabetes, and hypertension were common findings and were observed in 12 ( 55%), 14 ( 64%), and 13 ( 59%) of the 22 patients, respectively. The serum alpha-fetoprotein level was elevated in eight patients ( 36%). All patients had pathologic evidence of NAFLD. HCC was well-differentiated in seven patients, moderately differentiated in 11, and poorly differentiated in four. Large tumors ( mean diameter, 8.4 cm) were depicted at CT and/or MR imaging in all patients. Twenty-one patients had a solitary or dominant mass. At imaging, tumor margins were well defined in 17 patients, with a smooth surface in 17, and there was evidence of a tumor capsule in 15. Necrosis was depicted in 16 patients. There was no evidence of calcifications, central scar, fat, or abdominal lymphadenopathy. CT was performed in 20 patients. HCC was hypoattenuating on unenhanced CT scans in 14 patients, heterogeneously hyperattenuating in the arterial phase in 20, and hypoattenuating in the portal phase in 14. MR imaging was performed in 16 patients. HCC was hyperintense compared with liver parenchyma at T2-weighted MR imaging in all 16 patients, hypointense at T1-weighted imaging in 14, heterogeneously hyperintense at arterial phase T1-weighted imaging in 16, and hypointense at portal phase T1-weighted imaging in 14. Conclusion: HCC in patients with NAFLD is more likely to manifest as a large solitary or dominant mass characterized by smooth and possibly encapsulated margins, necrosis, and hyper-vascularity. (c) RSNA, 2007.
    RADIOLOGICAL SOC NORTH AMERICA, 2007年05月, RADIOLOGY, 243(2) (2), 422 - 430, 英語
    研究論文（学術雑誌）

  • Riccardo Iannaccone, Francesca Piacentini, Takamichi Murakami, Valerie Paradis, Jacques Belghiti, Masatoshi Hori, Tonsok Kim, Francois Durand, Kenichi Wakasa, Morito Monden, Hironobu Nakamura, Roberto Passariello, Valerie Vilgrain
    Purpose: To retrospectively evaluate the clinical, pathologic, and helical computed tomographic ( CT) and magnetic resonance ( MR) imaging findings of hepatocellular carcinoma ( HCC) in patients with nonalcoholic fatty liver disease ( NAFLD). Materials and Methods: Institutional review board approval was obtained for this study; the need for patient informed consent was waived. Clinical, pathologic, and imaging findings were retrospectively evaluated in 22 men ( mean age, 64.5 years) with HCC and NAFLD. Helical CT and MR images were reviewed for morphologic features such as tumor size, margins, necrosis, and degree of enhancement. Results: Obesity, diabetes, and hypertension were common findings and were observed in 12 ( 55%), 14 ( 64%), and 13 ( 59%) of the 22 patients, respectively. The serum alpha-fetoprotein level was elevated in eight patients ( 36%). All patients had pathologic evidence of NAFLD. HCC was well-differentiated in seven patients, moderately differentiated in 11, and poorly differentiated in four. Large tumors ( mean diameter, 8.4 cm) were depicted at CT and/or MR imaging in all patients. Twenty-one patients had a solitary or dominant mass. At imaging, tumor margins were well defined in 17 patients, with a smooth surface in 17, and there was evidence of a tumor capsule in 15. Necrosis was depicted in 16 patients. There was no evidence of calcifications, central scar, fat, or abdominal lymphadenopathy. CT was performed in 20 patients. HCC was hypoattenuating on unenhanced CT scans in 14 patients, heterogeneously hyperattenuating in the arterial phase in 20, and hypoattenuating in the portal phase in 14. MR imaging was performed in 16 patients. HCC was hyperintense compared with liver parenchyma at T2-weighted MR imaging in all 16 patients, hypointense at T1-weighted imaging in 14, heterogeneously hyperintense at arterial phase T1-weighted imaging in 16, and hypointense at portal phase T1-weighted imaging in 14. Conclusion: HCC in patients with NAFLD is more likely to manifest as a large solitary or dominant mass characterized by smooth and possibly encapsulated margins, necrosis, and hyper-vascularity. (c) RSNA, 2007.
    RADIOLOGICAL SOC NORTH AMERICA, 2007年05月, RADIOLOGY, 243(2) (2), 422 - 430, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Daniele Marin, Riccardo Iannaccone, Andrea Laghi, Carlo Catalano, Takamichi Murakami, Masatoshi Hori, Tonsok Kim, Roberto Passariello
    Purpose: To intraindividually compare the enhancement pattern of focal nodular hyperplasia (FNH) after dynamic administration of two bolus-injectable liver-specific MR contrast agents, ferucarbotran and gadobenate dimeglumine. Materials and Methods: A total of 19 patients with 24 FNHs underwent gadobenate dimeglumine- and ferucarbotran-enhanced MRI during the hepatic arterial-dominant phase (HAP; 25 seconds), the portal-venous phase (PVP; 60 seconds), and the equilibrium phase (EP; 180 seconds). Hepatospecific phases were acquired on T1-weighted images 120 minutes after gadobenate dimeglumine administration, and on T2-weighted images 10 minutes after ferucarbotran administration. Lesion enhancement was independently analyzed by two observers. The kappa statistic was determined to evaluate the agreement between the enhancement patterns of the lesions. Results: On gadobenate dimeglumine- enhanced MR images during HAP, PVP, and EP, FNHs were: hyperintense (24/20/13); isointense (0/4/11); and hypointense (0/0/0). On ferucarbotran-enhanced MR images during HAP, PVP, and EP, FNHs were: hyperintense (2/0/0); isointense (16/9/14); and hypointense (6/15/10). Overall, poor agreement between both contrast agents was observed. During the hepatospecific phases, most (20/24; 83%) FNHs showed a typical enhancement pattern during the delayed hepatospecific phase. Conclusion: The dynamic enhancement pattern of FNHs is significantly different between gadobenate: dimeglumine- and ferucarbotran-enhanced MRI. With respect to hepatospecific phase, the majority of FNHs showed a typical behavior on both contrast agents.
    JOHN WILEY & SONS INC, 2007年04月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 25(4) (4), 775 - 782, 英語
    研究論文（学術雑誌）

  • 肝がんと闘う. 世界に冠たる日本の診療.
    工藤 正俊, 村上 卓道
    22: 1
    2007年04月, INNERVISION INNERVISION, 22(4) (4), 1 - 2

  • Kazuhiko Hashimoto, Takamichi Murakami, Keizo Dono, Masatoshi Hori, Tonsok Kim, Masayuki Kudo, Shigeru Marubashi, Atsushi Miyamoto, Yutaka Takeda, Hiroaki Nagano, Koji Umeshita, Hironobu Nakamura, Morito Monden
    The purpose of this study was to compare measurements of hepatic tissue blood flow (TBF) calculated by xenon and perfusion CT. Seven patients with normal liver and eight with chronic liver disease underwent both xenon and perfusion CT. During xenon CT examinations, serial abdominal CT scans were obtained every minute before and during 4 min of nonradioactive 25% (v/v) xenon gas inhalation and 5 min of administration of oxygen-rich air. Hepatic arterial and portal venous TBF were measured separately with a special imaging system using the Kety-Schmidt expression based on the Fick principle (AZ-7000W; Anzai Medical Co.). The hepatic arterial fraction (HAF) was calculated as follows: [hepatic arterial TBF/(hepatic arterial TBF + portal venous TBF)]. During perfusion CT examinations, total hepatic TBF and HAF were also calculated from the enhanced CT cine image data on a workstation using a commercially available software package based on a deconvolution algorithm (CT Perfusion 3 GE Healthcare, USA). Total hepatic TBF measured by xenon and perfusion CT was 82.9 +/- 15 and 82.8 +/- 18 ml/min/100 g, respectively. The measured values by the two techniques showed a significant correlation (R-2 = 0.657, P < 0.05). HAF measured by xenon and perfusion CT was 26.6 +/- 11 and 21.8 +/- 13%, respectively. The measured values by the two techniques also showed a significant correlation (R-2 = 0.869, P < 0.05). We conclude that there was a good correlation between hepatic TBF quantified by xenon CT and perfusion CT.
    SPRINGER, 2007年04月, DIGESTIVE DISEASES AND SCIENCES, 52(4) (4), 943 - 949, 英語
    研究論文（学術雑誌）

  • Natsuko Tsuda, Masahiro Okada, Takamichi Murakami
    RATIONALE AND OBJECTIVES: To investigate the potential of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) for the differential diagnosis of nonalcoholic steatohepatitis (NASH) and fatty liver (FL). METHODS: Twenty-one male rats were divided into 3 groups. Seven rats in the NASH group were fed a choline-deficient diet for 10 weeks, and the 7 rats in the FL group were fed a standard diet also containing 1% (wt/wt) orotic acid for 4 weeks. As a control, 7 rats were fed a standard diet. After the feeding period, all rats were subjected to contrast-enhanced dynamic and delayed MRI with a 2D-FLASH technique. Gd-DTPA (0.1 mmol Gd/kg) and Gd-EOB-DTPA (0.025 mmol Gd/kg) were injected into the tail vein at 24-hour intervals. Signal intensities of the liver were measured for each MR image and the relative enhancement (RE) was calculated. In addition, the time of maximum RE (Tmax) and the half-life of RE (T1/2) in liver were compared. After MRI, the liver was histologically analyzed to evaluate steatosis, hepatitis, and fibrosis. RESULTS: Diffuse macrovesicular steatosis and severe fibrosis were observed in the NASH group, whereas diffuse microvesicular steatosis and rare fibrosis were observed in the FL group. Immediately after the Gd-DTPA injection, the RE in the liver of each group temporarily increased, and thereafter, rapid RE reduction was observed. However, a continuous increase and subsequent slow reduction of RE were induced after the Gd-EOB-DTPA injection. Although there was no difference between the Tmax and T1/2 of each group after the Gd-DTPA injection, Tmax and T1/2 of the NASH group were significantly prolonged in comparison with FL and control groups after the Gd-EOB-DTPA injection (P < 0.01). CONCLUSIONS: It was possible to differentiate NASH and FL by evaluating the SI time course on Gd-EOB-DTPA enhanced MRI. © 2007 Lippincott Williams & Wilkins, Inc.
    2007年04月, Investigative Radiology, 42(4) (4), 242 - 247, 英語
    研究論文（学術雑誌）

  • Kazuhiko Hashimoto, Takamichi Murakami, Keizo Dono, Masatoshi Hori, Tonsok Kim, Masayuki Kudo, Shigeru Marubashi, Atsushi Miyamoto, Yutaka Takeda, Hiroaki Nagano, Koji Umeshita, Hironobu Nakamura, Morito Monden
    The purpose of this study was to compare measurements of hepatic tissue blood flow (TBF) calculated by xenon and perfusion CT. Seven patients with normal liver and eight with chronic liver disease underwent both xenon and perfusion CT. During xenon CT examinations, serial abdominal CT scans were obtained every minute before and during 4 min of nonradioactive 25% (v/v) xenon gas inhalation and 5 min of administration of oxygen-rich air. Hepatic arterial and portal venous TBF were measured separately with a special imaging system using the Kety-Schmidt expression based on the Fick principle (AZ-7000W; Anzai Medical Co.). The hepatic arterial fraction (HAF) was calculated as follows: [hepatic arterial TBF/(hepatic arterial TBF + portal venous TBF)]. During perfusion CT examinations, total hepatic TBF and HAF were also calculated from the enhanced CT cine image data on a workstation using a commercially available software package based on a deconvolution algorithm (CT Perfusion 3 GE Healthcare, USA). Total hepatic TBF measured by xenon and perfusion CT was 82.9 +/- 15 and 82.8 +/- 18 ml/min/100 g, respectively. The measured values by the two techniques showed a significant correlation (R-2 = 0.657, P < 0.05). HAF measured by xenon and perfusion CT was 26.6 +/- 11 and 21.8 +/- 13%, respectively. The measured values by the two techniques also showed a significant correlation (R-2 = 0.869, P < 0.05). We conclude that there was a good correlation between hepatic TBF quantified by xenon CT and perfusion CT.
    SPRINGER, 2007年04月, DIGESTIVE DISEASES AND SCIENCES, 52(4) (4), 943 - 949, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Daniele Marin, Riccardo Iannaccone, Andrea Laghi, Carlo Catalano, Takamichi Murakami, Masatoshi Hori, Tonsok Kim, Roberto Passariello
    Purpose: To intraindividually compare the enhancement pattern of focal nodular hyperplasia (FNH) after dynamic administration of two bolus-injectable liver-specific MR contrast agents, ferucarbotran and gadobenate dimeglumine. Materials and Methods: A total of 19 patients with 24 FNHs underwent gadobenate dimeglumine- and ferucarbotran-enhanced MRI during the hepatic arterial-dominant phase (HAP; 25 seconds), the portal-venous phase (PVP; 60 seconds), and the equilibrium phase (EP; 180 seconds). Hepatospecific phases were acquired on T1-weighted images 120 minutes after gadobenate dimeglumine administration, and on T2-weighted images 10 minutes after ferucarbotran administration. Lesion enhancement was independently analyzed by two observers. The kappa statistic was determined to evaluate the agreement between the enhancement patterns of the lesions. Results: On gadobenate dimeglumine- enhanced MR images during HAP, PVP, and EP, FNHs were: hyperintense (24/20/13); isointense (0/4/11); and hypointense (0/0/0). On ferucarbotran-enhanced MR images during HAP, PVP, and EP, FNHs were: hyperintense (2/0/0); isointense (16/9/14); and hypointense (6/15/10). Overall, poor agreement between both contrast agents was observed. During the hepatospecific phases, most (20/24; 83%) FNHs showed a typical enhancement pattern during the delayed hepatospecific phase. Conclusion: The dynamic enhancement pattern of FNHs is significantly different between gadobenate: dimeglumine- and ferucarbotran-enhanced MRI. With respect to hepatospecific phase, the majority of FNHs showed a typical behavior on both contrast agents.
    JOHN WILEY & SONS INC, 2007年04月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 25(4) (4), 775 - 782, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Natsuko Tsuda, Masahiro Okada, Takamichi Murakami
    Rationale and Objectives: To investigate the potential of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) for the differential diagnosis of nonalcoholic steatohepatitis (NASH) and fatty liver (FL). Methods: Twenty-one male rats were divided into 3 groups. Seven rats in the NASH group were fed a choline-deficient diet for 10 weeks, and the 7 rats in the FL group were fed a standard diet also containing 1% (wt/wt) orotic acid for 4 weeks. As a control, 7 rats were fed a standard diet. After the feeding period, all rats were subjected to contrast-enhanced dynamic and delayed MRI with a 2D-FLASH technique. Gd-DTPA (0.1 mmol Gd/kg) and Gd-EOB-DTPA (0.025 mmol Gd/kg) were injected into the tail vein at 24-hour intervals. Signal intensities of the liver were measured for each MR image and the relative enhancement (RE) was calculated. In addition, the time of maximum RE (T-max) and the half-life of RE (T-1/2) in liver were compared. After MRI, the liver was histologically analyzed to evaluate steatosis, hepatitis, and fibrosis. Results: Diffuse macrovesicular steatosis and severe fibrosis were observed in the NASH group, whereas diffuse microvesicular steatosis and rare fibrosis were observed in the FL group. Immediately after the Gd-DTPA injection, the RE in the liver of each group temporarily increased, and thereafter, rapid RE reduction was observed. However, a continuous increase and subsequent slow reduction of RE were induced after the Gd-EOB-DTPA injection. Although there was no difference between the T-max and T-1/2 of each group after the Gd-DTPA injection, T-max and T-1/2 of the NASH group were significantly prolonged in comparison with FL and control groups after the Gd-EOB-DTPA injection (P < 0.01). Conclusions: It was possible to differentiate NASH and FL by evaluating the SI time course on Gd-EOB-DTPA enhanced MRI.
    LIPPINCOTT WILLIAMS & WILKINS, 2007年04月, INVESTIGATIVE RADIOLOGY, 42(4) (4), 242 - 247, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 肝門部胆管癌術後に生じた門脈狭窄に対して門脈ステント留置を行った1例
    児玉 彩, 柳生 行伸, 桑原 雅知, 任 誠雲, 米矢 吉宏, 土屋 典生, 岡田 真広, 坪山 尚寛, 葉 輝明, 清水 利栄, 小塚 健倫, 今岡 いずみ, 下野 太郎, 足利 竜一朗, 細野 眞, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2007年04月, IVR: Interventional Radiology, 22(2) (2), 266 - 266, 日本語

  • S. Takahashi, M. Takamura, S. Yamamoto, M. Kudo, Y. Narumi, T. Murakami, H. Nakamura
    Purpose: To determine the effects of detector configuration, as well as vessel orientation, on the depiction accuracy of arterial stenosis using four-channel multidetector-row helical computed tomography (MDCT) angiography in vitro. Material and Methods: Five acrylic vessel phantoms (3 mm in diameter with 25 or 50% stenosis, or 5 mm with 25, 50, or 75% stenosis) were scanned with a four-channel MDCT scanner at five vessel orientations (0, 30, 45, 60, and 90 to the z-axis) using 4 x 1.25, 2.5, 3.75, and 5.0-mm detector configurations at beam pitches of 0.75 and 1.5. The percentage of stenosis was calculated by the ratio of the full width at half maximum for stenotic and non-stenotic portions of the phantom, and compared to the actual known values. Results: A detector configuration of 4 x 1.25 mm provided good reproducibility, as well as high accuracy for assessing vessel stenosis, while a 4 x 2.5-mm or wider detector configuration caused underestimations of stenosis. Although the phantoms perpendicular to the z-axis were underestimated, the errors were kept in clinically acceptable ranges using the 4 x 1.25-mm detector configuration. Conclusion: Four-channel MDCT accurately discerns stenosis for vessel phantoms of 3 or 5 mm in diameter at any orientation when using a detector configuration of 4 x 1.25 mm.
    TAYLOR & FRANCIS LTD, 2007年03月, ACTA RADIOLOGICA, 48(2) (2), 173 - 179, 英語
    研究論文（学術雑誌）

  • クロイツフェルト・ヤコブ病(CJD)のMRI診断において詳細な読影をする前に可能性を想起できるか?
    下野 太郎, 坪山 尚寛, 桑原 雅知, 任 誠雲, 柳生 行伸, 今岡 いずみ, 小塚 健倫, 足利 竜一朗, 細野 眞, 村上 卓道
    (公社)日本医学放射線学会, 2007年02月, 日本医学放射線学会学術集会抄録集, 66回, S306 - S307, 日本語

  • Katsuyuki Nakanishi, Midori Kobayashi, Kazunori Nakaguchi, Miyaji Kyakuno, Nobuyuki Hashimoto, Hiromitsu Onishi, Noboru Maeda, Saki Nakata, Masatomo Kuwabara, Takamichi Murakami, Hironobu Nakamura
    Purpose: We assessed the diagnostic value of whole body magnetic resonance (MR) imaging (WB-MRI) using diFfusion-weighted images (DWI) for detecting bone metastasis and compared it with that of skeletal scintigraphy (SS). Materials and Methods: Thirty patients with malignancies (breast cancer, 17 patients prostate cancer, 9 and one patient each, thyroid cancer, liposarcoma, leiomyosarcoma, and extraskeletal Ewing sarcoma) underwent both WB-MRI and SS to detect bone metastasis. All patients were followed more than 6 months by MR imaging, SS, or computed tomographic (CT) examination. For WB-MRI, patients were placed in feet rest supine position with table-top extender and quadrature body coil. We acquired DWI (axial plane from lower neck to proximal femur) (single shot short TI inversion-recovery [STIR]: repetition time [TR] 6243/echo time [TE] 59/inversion time [TI] 180 ms b value: 600 s/mm2 5-mm slice thickness 112×112 matrix), T1-weighted fast spin echo (T1WI), and STIR (sagittal plane of total spine images and coronal plane of whole body images) images. Four blinded readers independently and separately interpreted images of combined MR sequences of Twister (session 1) and T1WI+STIR+DWI (session 2). Results: In 10 of 30 patients, we detected a total of 52 metastatic bone lesions in the other 20, follow-up examinations conformed no metastatic bone lesions. For these 52 lesions, for session 2, the mean sensitivity was 96z and the positive predictive value (PPV) was 98z. Those values were superior to those of session 1 (sensitivity: 88z PPV: 95z) and those of SS (sensitivity: 96z PPV: 94z). Conclusion: WB-MRI that included DWI was useful for detecting bone metastasis.
    2007年, Magnetic Resonance in Medical Sciences, 6(3) (3), 147 - 155, 英語
    研究論文（学術雑誌）

  • MR撮像法の臨床応用脂肪抑制法の原理
    中塚 隆之, 西松 和彦, 村上 卓道
    2007年, 日独医報, 52(3) (3), 371 - 388

  • TAGEにおける抗癌剤：併用する抗癌剤よその効果
    前田 登, 村上 卓道, 大須賀慶悟
    2007年, 肝胆膵, 55(5) (5), 805 - 812

  • 卵巣腫瘍と鑑別が困難であった限局性腹膜偽粘液腫の一例
    清水利栄, 今岡 いずみ, 下野 太郎, 葉輝明, 任 誠雲, 坪山尚寛, 足利 竜一朗, 村上 卓道
    2007年, 臨床放射線, 52, 700 - 703

  • Seishi Kumano, Takaharu Tsuda, Hiroaki Tanaka, Masaaki Hirata, Tonsok Kim, Takamichi Murakami, Eiji Sugihara, Hisashi Abe, Hirotaka Yamashita, Nobuaki Kobayashi, Teruhito Mochizuki
    PURPOSE: The purpose of this study was to evaluate the efficacy of 3-dimensional computed tomographic angiography (3D CTA) using 16-channel multidetector-row helical computed tomography (MDCT) in the preoperative visualization of laparoscopic gastrectomy for early gastric cancer. MATERIALS AND METHODS: Twenty consecutive patients with early gastric cancer who underwent computed tomographic (CT) examination using 16-channel MDCT (0.625 mm x 16) before surgery were included in this study. At a rate of 4 mL/s, 2 mL/kg of 300 mg I/mL contrast material was intravenously injected. Timing for arterial phase scanning was determined by using a test bolus injection. Portal phase imaging was performed 70 seconds after the start of bolus injection. By using volume rendering and maximum intensity projection techniques, 3D CT angiograms of perigastric vessels were reconstructed from CT images of 0.625-mm thickness on computer workstations. RESULTS: In all cases, the left gastric artery (LGA) and the right gastric artery were correctly identified on 3D CTA, and the left gastric vein was also depicted on 3D CTA in all cases. In 2 cases, the aberrant left hepatic artery from LGA was correctly identified on 3D CTA. In 1 case, the accessory LGA from the left hepatic artery was correctly identified on 3D CTA. The variations of the veins included the left gastric vein flowing into the portal vein in 10 cases: the splenic vein in 9 and the junction of the portal and splenic veins in 1. CONCLUSIONS: A 3D CTA reconstructed from 16-channel MDCT images clearly revealed perigastric vascular anatomy in all cases, which is important for laparoscopic gastrectomy. Three-dimensional CTA is useful for the preoperative visualization of laparoscopic gastrectomy. © 2007 Lippincott Williams & Wilkins, Inc.
    2007年01月, Journal of Computer Assisted Tomography, 31(1) (1), 93 - 97, 英語
    研究論文（学術雑誌）

  • Seishi Kumano, Takaharu Tsuda, Hiroaki Tanaka, Masaaki Hirata, Tonsok Kim, Takamichi Murakami, Eiji Sugihara, Hisashi Abe, Hirotaka Yamashita, Nobuaki Kobayashi, Teruhito Mochizuki
    Purpose: The purpose of this study was to evaluate the efficacy of 3-dimensional computed tomographic angiography (3D CTA) using 16-channel multidetector-row helical computed tomography (MDCT) in the preoperative visualization of laparoscopic gastrectomy for early gastric cancer. Materials and Methods: Twenty consecutive patients with early gastric cancer who underwent computed tomographic (CT) examination using 16-channel MDCT (0.625 mm x 16) before surgery were included in this study. At a rate of 4 mL/s, 2 mL/kg of 300 mg I/mL contrast material was intravenously injected. Timing for arterial phase scanning was determined by using a test bolus injection. Portal phase imaging was performed 70 seconds after the start of bolus injection. By using volume rendering and maximum intensity projection techniques, 31) CT angiograms of perigastric vessels were reconstructed from CT images of 0.625-mm thickness on computer workstations. Results: In all cases, the left gastric artery (LGA) and the right gastric artery were correctly identified on 3D CTA, and the left gastric vein was also depicted on 3D CTA in all cases. In 2 cases, the aberrant left hepatic artery from LGA was correctly identified on 3D CTA. In I case, the accessory LGA from the left hepatic artery was correctly identified on 3D CTA. The variations of the veins included the left gastric vein flowing into the portal vein in 10 cases: the splenic vein in 9 and the junction of the portal and splenic veins in 1. Conclusions: A 3D CTA reconstructed from 16-channel MDCT images clearly revealed perigastric vascular anatomy in all cases, which is important for laparoscopic gastrectomy. Three-dimensional CTA is useful for the preoperative visualization of laparoscopic gastrectomy.
    LIPPINCOTT WILLIAMS & WILKINS, 2007年01月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 31(1) (1), 93 - 97, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Katsuyuki Nakanishi, Midori Kobayashi, Kazunori Nakaguchi, Miyaji Kyakuno, Nobuyuki Hashimoto, Hiromitsu Onishi, Noboru Maeda, Saki Nakata, Masatomo Kuwabara, Takamichi Murakami, Hironobu Nakamura
    Purpose: We assessed the diagnostic value of whole body magnetic resonance (MR) imaging (WB-MRI) using diFfusion-weighted images (DWI) for detecting bone metastasis and compared it with that of skeletal scintigraphy (SS). Materials and Methods: Thirty patients with malignancies (breast cancer, 17 patients prostate cancer, 9 and one patient each, thyroid cancer, liposarcoma, leiomyosarcoma, and extraskeletal Ewing sarcoma) underwent both WB-MRI and SS to detect bone metastasis. All patients were followed more than 6 months by MR imaging, SS, or computed tomographic (CT) examination. For WB-MRI, patients were placed in feet rest supine position with table-top extender and quadrature body coil. We acquired DWI (axial plane from lower neck to proximal femur) (single shot short TI inversion-recovery [STIR]: repetition time [TR] 6243/echo time [TE] 59/inversion time [TI] 180 ms b value: 600 s/mm2 5-mm slice thickness 112×112 matrix), T1-weighted fast spin echo (T1WI), and STIR (sagittal plane of total spine images and coronal plane of whole body images) images. Four blinded readers independently and separately interpreted images of combined MR sequences of Twister (session 1) and T1WI+STIR+DWI (session 2). Results: In 10 of 30 patients, we detected a total of 52 metastatic bone lesions in the other 20, follow-up examinations conformed no metastatic bone lesions. For these 52 lesions, for session 2, the mean sensitivity was 96z and the positive predictive value (PPV) was 98z. Those values were superior to those of session 1 (sensitivity: 88z PPV: 95z) and those of SS (sensitivity: 96z PPV: 94z). Conclusion: WB-MRI that included DWI was useful for detecting bone metastasis.
    3, 2007年, Magnetic Resonance in Medical Sciences, 6(3) (3), 147 - 155, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tonsok Kim, Takamichi Murakami, Satoru Takahashi, Masatoshi Hori, Shirou Takahara, Naotsugu Ichimaru, Akihiko Okuyama, Yoshifumi Narumi, Hironobu Nakamura
    Purpose. The purpose of this study was to clarify and compare the accuracy of contrast-enhanced computed tomography (CT) angiography using multidetector-row helical CT (MDCT angiography) and gadolinium-enhanced MR angiography using three-dimensional Fourier transformation gradient-echo sequence (3D MR angiography) for preoperative evaluation of renal arteries in living renal donors. Materials and methods. A total of 42 living renal donor candidates underwent both MDCT angiography and 3D MR angiography before digital subtraction angiography (DSA). Each MDCT angiogram and 3D MR angiogram was prospectively interpreted, and the findings were compared with the DSA results. Results. MDCT angiography identified all of the 12 supernumerary arteries detected by DSA, whereas 3D MR angiography identified only 8. MDCT angiography identified all of the 19 proximal arterial branches detected by DSA, whereas 3D MR angiography identified only 16. Conclusion. A more accurate depiction of renal arteries in living renal donors can be achieved with MDCT angiography than with 3D MR angiography. © Japan Radiological Society 2006.
    2006年11月, Radiation Medicine - Medical Imaging and Radiation Oncology, 24(9) (9), 617 - 624, 英語
    研究論文（学術雑誌）

  • Taishi Hata, Masataka Ikeda, Shoji Nakamori, Rei Suzuki, Tonsok Kim, Masayoshi Yasui, Ichiro Takemasa, Masakazu Ikenaga, Hirofumi Yamamoto, Masayuki Ohue, Takamichi Murakami, Mitsugu Sekimoto, Masato Sakon, Morito Monden
    The aim of the study was to evaluate the usefulness of serial lung perfusion scintigraphy prospectively using single-photon emission computed tomographic image (SPECT) in screening for pulmonary embolism (PE) after elective surgery for gastrointestinal malignancy. PE was examined pre- and postoperatively with SPECT. Diagnosis of PE was based on segmental perfusion defect visualization in at least two of three planes on a SPECT image compared with preoperative SPECT images. Final diagnosis was determined by detection of embolus with multidetector helical CT (MDCT). No perioperative anticoagulant was used. Thirty-four patients were enrolled. One patient was excluded because of thrombophilia. In preoperative scans, nonsegmental defects were detected in 11 and a segmental defect in 1 patient, who was then diagnosed as PE preoperatively. Among 21 patients with normal preoperative SPECT, 2 had nonsegmental and 5 had segmental defects postoperatively. Among 11 patients with nonsegmental preoperative SPECT, 7 had nonsegmental and 4 had segmental defects postoperatively. Postoperative segmental defects were differentiated by their shape only and there was no need to compare pre- and postoperative SPECT. MDCT confirmed four patients with PE among nine with segmental defects postoperatively. Our results of screening for PE by visualization at least two planes of SPECT images suggest that postoperative SPECT scan is suitable for the diagnosis of postoperative PE.
    SPRINGER, 2006年11月, DIGESTIVE DISEASES AND SCIENCES, 51(11) (11), 2073 - 2080, 英語
    研究論文（学術雑誌）

  • Taishi Hata, Masataka Ikeda, Shoji Nakamori, Rei Suzuki, Tonsok Kim, Masayoshi Yasui, Ichiro Takemasa, Masakazu Ikenaga, Hirofumi Yamamoto, Masayuki Ohue, Takamichi Murakami, Mitsugu Sekimoto, Masato Sakon, Morito Monden
    The aim of the study was to evaluate the usefulness of serial lung perfusion scintigraphy prospectively using single-photon emission computed tomographic image (SPECT) in screening for pulmonary embolism (PE) after elective surgery for gastrointestinal malignancy. PE was examined pre- and postoperatively with SPECT. Diagnosis of PE was based on segmental perfusion defect visualization in at least two of three planes on a SPECT image compared with preoperative SPECT images. Final diagnosis was determined by detection of embolus with multidetector helical CT (MDCT). No perioperative anticoagulant was used. Thirty-four patients were enrolled. One patient was excluded because of thrombophilia. In preoperative scans, nonsegmental defects were detected in 11 and a segmental defect in 1 patient, who was then diagnosed as PE preoperatively. Among 21 patients with normal preoperative SPECT, 2 had nonsegmental and 5 had segmental defects postoperatively. Among 11 patients with nonsegmental preoperative SPECT, 7 had nonsegmental and 4 had segmental defects postoperatively. Postoperative segmental defects were differentiated by their shape only and there was no need to compare pre- and postoperative SPECT. MDCT confirmed four patients with PE among nine with segmental defects postoperatively. Our results of screening for PE by visualization at least two planes of SPECT images suggest that postoperative SPECT scan is suitable for the diagnosis of postoperative PE.
    SPRINGER, 2006年11月, DIGESTIVE DISEASES AND SCIENCES, 51(11) (11), 2073 - 2080, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tonsok Kim, Takamichi Murakami, Satoru Takahashi, Masatoshi Hori, Shirou Takahara, Naotsugu Ichimaru, Akihiko Okuyama, Yoshifumi Narumi, Hironobu Nakamura
    Purpose. The purpose of this study was to clarify and compare the accuracy of contrast-enhanced computed tomography (CT) angiography using multidetector-row helical CT (MDCT angiography) and gadolinium-enhanced MR angiography using three-dimensional Fourier transformation gradient-echo sequence (3D MR angiography) for preoperative evaluation of renal arteries in living renal donors. Materials and methods. A total of 42 living renal donor candidates underwent both MDCT angiography and 3D MR angiography before digital subtraction angiography (DSA). Each MDCT angiogram and 3D MR angiogram was prospectively interpreted, and the findings were compared with the DSA results. Results. MDCT angiography identified all of the 12 supernumerary arteries detected by DSA, whereas 3D MR angiography identified only 8. MDCT angiography identified all of the 19 proximal arterial branches detected by DSA, whereas 3D MR angiography identified only 16. Conclusion. A more accurate depiction of renal arteries in living renal donors can be achieved with MDCT angiography than with 3D MR angiography. © Japan Radiological Society 2006.
    9, 2006年11月, Radiation Medicine - Medical Imaging and Radiation Oncology, 24(9) (9), 617 - 624, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Carlos Valls, Ricardo Iannacconne, Esther Alba, Takamichi Murakami, Masatoshi Hori, Roberto Passariello, Valerie Vilgrain
    The purpose of this article is to provide an update on imaging techniques useful for detection and characterization of fat in the liver. Imaging findings of liver steatosis, both diffuse steatosis and focal fatty change, as well as focal fatty sparing, are presented. In addition, we will review computed tomography (CT) and magnetic resonance (MR) findings of focal liver lesions with fatty metamorphosis, including hepatocellular carcinoma, hepatocellular adenoma, focal nodular hyperplasia, angiomyolipoma, lipoma, and metastases.
    SPRINGER, 2006年10月, EUROPEAN RADIOLOGY, 16(10) (10), 2292 - 2308, 英語
    研究論文（学術雑誌）

  • Carlos Valls, Ricardo Iannacconne, Esther Alba, Takamichi Murakami, Masatoshi Hori, Roberto Passariello, Valerie Vilgrain
    The purpose of this article is to provide an update on imaging techniques useful for detection and characterization of fat in the liver. Imaging findings of liver steatosis, both diffuse steatosis and focal fatty change, as well as focal fatty sparing, are presented. In addition, we will review computed tomography (CT) and magnetic resonance (MR) findings of focal liver lesions with fatty metamorphosis, including hepatocellular carcinoma, hepatocellular adenoma, focal nodular hyperplasia, angiomyolipoma, lipoma, and metastases.
    SPRINGER, 2006年10月, EUROPEAN RADIOLOGY, 16(10) (10), 2292 - 2308, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Assessment of the severity of liver disease and fibrotic change: The usefulness of hepatic CT perfusion imaging
    Kazuhiko Hashimoto, Takamichi Murakami, Keizo Dono, Masatoshi Hori, Tonsok Kim, Masayuki Kudo, Shigeru Marubashi, Atsushi Miyamoto, Yutaka Takeda, Hiroaki Nagano, Koji Umeshita, Hironobu Nakamura, Morito Monden
    This study assessed the utility of CT perfusion for quantitative assessment of liver function and fibrosis. Tissue blood flow (TBF), tissue blood volume (TBV), mean transit time (MTT) and hepatic arterial fraction (HAF) were measured with CT perfusion using the deconvolution algorithm in 38 patients with chronic liver diseases and 10 patients without liver disease. Using Child-Pugh classification, 21 patients were classified as Child A, 10 as Child B, and 7 as Child C. In 20 patients, the degree of fibrosis was quantitated in surgically-resected specimens and compared with the perfusion parameters. The mean TBF, TBV, MTT and HAF of patients without liver disease were 103.9 +/- 18 ml/min/100 g, 12.5 +/- 2.0 ml/100 g, 11.1 +/- 1.6 sec and 18.4 +/- 5.6%, respectively (+/- SD). The mean TBF of patients with Child A, B and C were 95.1 +/- 24, 86.7 +/- 29 and 75.5 +/- 6.5 ml/min/100 g, respectively. TBF tended to decrease with the severity of chronic liver disease. The mean HAF of patients with Child A, B and C were 18.6 +/- 8.3, 29.8 +/- 11.2 and 40.2 +/- 11.1%, respectively. HAF of patients without liver disease was significantly different from those of Child B and C (p < 0.05, each). However, there were no significant differences in TBV and MTT between each groups. HAF correlated significantly with the degree of fibrosis (R-2-0.588, p < 0.05). Our results showed that parameters of CT perfusion correlated significantly with the severity of liver fibrosis and cirrhosis. Quantitative measurement of hepatic tissue blood flow by CT perfusion is useful for evaluation of the severity of disease and fibrotic change.
    PROFESSOR D A SPANDIDOS, 2006年10月, ONCOLOGY REPORTS, 16(4) (4), 677 - 683, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Real-time Virtual Sonography(RVS)ガイド下ラジオ波焼灼療法(RFA)の有用性についての検討
    北田 学利, 村上 卓道, 葛下 典由, 松田 高明, 南谷 かおり, 中条 和也, 大須賀 慶吾, 三善 英知, 中村 仁信, 岸野 文一郎, 田村 信司, 林 紀夫
    (一社)日本肝臓学会, 2006年09月, 肝臓, 47(Suppl.2) (Suppl.2), A455 - A455, 日本語

  • Assessment of the severity of liver disease and fibrotic change: The usefulness of hepatic CT perfusion imaging.
    橋本和彦, 村上 卓道
    2006年08月, Oncology Reports, 16, 677 - 683

  • Automated segmentation of liver from 3D CT images
    Amir H. Foruzan, Reza A. Zoroofi, Yoshinobu Sato, Masatoshi Hori, Takamichi Murakami, Hironobu Nakamura, Shinichi Tamura
    Liver automatic segmentation is very valuable for corresponding quantitative evaluations Automatic segmentation of liver using CT images is difficult due to similar intensity with respect to its surrounding tissues, poor in-plane and inter-plane resolutions, and partial volume effect. In this research, we propose a hybrid approach as follows. We generate color CT images using a heuristic transfer function followed by estimating the liver regions of the color images by a wavelet based texture based approach. We then calculate the cross correlation of the histogram of the liver with a small windows within each slice and finalize the liver mask by employing a level set algorithm. The proposed algorithm is not sensitive to the shape, size and gray scales of the liver. The success of the techniques in the presence of the available randomly selected data set is around 90%.
    SPRINGER HEIDELBERG, 2006年06月, INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY, 1, 71 - 73, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Keigo Osuga, Koji Mikami, Hiroki Higashihara, Noboru Maeda, Takahiro Tsuboyama, Masatomo Kuwabara, Hiromitsu Onishi, Masatoshi Hori, Tonsok Kim, Kaname Tomoda, Takamichi Murakami, Hironobu Nakamura
    Transcatheter embolotherapy (TCE), a common procedure for interventional radiologists, comprises transcatheter delivery of embolic agents into target vessels in order to eliminate lesions or lesion-associated symptoms. Good knowledge of delivery catheters and embolic agents is essential to optimize embolization techniques and to obtain the desired therapeutic outcomes. In this review, we describe the principles and techniques of TCE for peripheral arterial and venous lesions featuring visceral aneurysms, peripheral and pulmonary arteriovenous malformations (AVMs), and varicoceles. © 2006 Japan Radiological Society.
    4, 2006年05月, Radiation Medicine - Medical Imaging and Radiation Oncology, 24(4) (4), 309 - 314, 英語
    [査読有り]

  • N Tanigawa, A Komemushi, S Kariya, H Kojima, Y Shomura, K Ikeda, N Omura, T Murakami, S Sawada
    Purpose: To prospectively investigate the relationship between initial clinical response and bone marrow edema pattern on preprocedural magnetic resonance (MR) images in vertebral bodies selected For percutaneous vertebroplasty (PVP). Materials and Institutional review board approval and written informed Methods: consent were obtained. PVP was performed for osteoporotic compression fractures in 80 consecutive patients (mean age. 72.4 years: range. 44-85 years : 67 women and 14 men: 157 vertebrae). Patients were divided into three groups according to the proportion of the vertebra in which the bone marrow edema pattern was observed on sagittal MR images: group 1.50% or more of the vertebra; group 2, less than 50%; group 3. no edema pattern observed. By using Wilcoxon rank sum test, Fisher exact test.. and Wilcoxon signed rank test. groups were examined for differences in treatment efficacy, which was defined as the difference between preprocedural and postprocedural pain as assessed by means Of visual analog scale (VAS) score at 1-3 days after PVP. Results: Forty-four patients were assigned to group 1, 14 to group 2, and 22 to group 3. No significant difference was seen between the groups with respect to age. sex. number of treated vertebrae, or preprocedural VAS score. In group 1, VAS score decreased from 7.5 before the procedure to 2.9 after (improvement of 4.6). In group 2. the score decreased front 6.8 to 3.1 (improvement. or 3.7). fit group 3, the score decreased from 7.0 to 4.3 (improvement of 2.7). Improvement was significantly greater in group than in group 3 (P <.005). Conclusion: PVP resulted in significantly greater clinical improvement in patients with an extensive bone marrow edema pattern than it) those without this pattern. (c) RSNA, 2006.
    RADIOLOGICAL SOC NORTH AMERICA, 2006年04月, RADIOLOGY, 239(1) (1), 195 - 200, 英語
    研究論文（学術雑誌）

  • H Onishi, T Murakami, T Kim, M Hori, R Iannaccone, M Kuwabara, H Abe, S Nakata, K Osuga, K Tomoda, R Passariello, H Nakamura
    Purpose: To retrospectively compare the accuracy in detection of hepatic metastases among contrast material-enhanced multi-detector row computed tomography (CT) alone, superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging alone, and a combination of contrast-enhanced CT and SPIO-enhanced MR imaging. Material and Methods: The ethics committee did not require its approval or informed consent for this retrospective study, which was compliant with Declaration of Helsinki principles. Data in 38 patients (22 men, 16 women; mean age, 64.5 years: range, 35-78 years) suspected of having hepatic metastases who underwent both contrast-enhanced CT and SPIO-enhanced MR imaging were retrospectively analyzed. Twenty-one of the 38 patients had 61 metastases. Seventeen of the 61 metastases were confirmed histologically; the remaining 44 metastases were defined with imaging follow-up. At MR imaging, SPIO-enhanced heavily T1-weighted images, T2*-weighted gradient echo images, and T2-weighted fast spin-echo images were evaluated. Contrast-enhanced multi-detector row CT images obtained in the portal phase were evaluated. Four blinded observers independently reviewed CT images, MR images. Diagnostic accuracy was evaluated by using the alternative free-response receiver operating characteristic (AFROC) method. Sensitivities and positive predictive values were also analyzed with the Fisher protected least significant difference test and generalized estimating equations. Results: The mean area under the AFROC curve for the combined approach (0.70) was significantly higher than that for SPIO-enhanced MR imaging alone (0.58. P < .05, Fisher protected least significant difference test), and there was no significant difference between each of them and that for contrast-enhanced CT alone (0.66). For all lesions, the mean sensitivity of combined imaging (0.59) was significantly higher than that of CT (0.48) or MR imaging (0.43) alone (P < .05, Fisher protected least significant difference test and generalized estimating equations). For all lesions, the mean positive predictive values were 0.82, 0.89, and 0.81, for combined MR and CT, CT alone, and MR alone, respectively. Conclusion: The addition of SPIO-enhanced MR imaging to contrast-enhanced multi-detector row CT (ie, combined analysis of SPIO-enhanced MR images and contrast-enhanced CT images) can improve sensitivity in the detection of hepatic metastases, although this improvement in sensitivity was not significant at AFROC analysis. (c) RSNA 2006.
    RADIOLOGICAL SOC NORTH AMERICA, 2006年04月, RADIOLOGY, 239(1) (1), 131 - 138, 英語
    研究論文（学術雑誌）

  • Masatomo Kuwabara, Yoshifumi Narumi, Satoru Takahashi, Yoshinobu Sato, Tonsok Kim, Takamichi Murakami, Hironobu Nakamura
    Purpose. The aim of this study was to evaluate the correlation between the renal artery cross-sectional area measured by multidetector computed tomography (MDCT) and the nephrogram area calculated by renal arteriography in potential living renal donors with duplicated renal arteries. Materials and methods. Medical records of 18 patients with duplicated renal arteries who underwent both MDCT angiography and renal arteriography between 2001 and 2003 were retrospectively reviewed. All 20 kidneys were evaluated. Renal artery cross-sectional areas were measured using the workstation to which the CT data were transferred the nephrogram areas on the digitized angiographic images were calculated using public domain software. Bland-Altman analysis was performed to compare the cross-sectional area ratio of the accessory arteries to the main renal arteries, with the ratios obtained from the nephrogram areas calculated from the arteriograms. Results. The mean cross-sectional areas of the accessory and main renal arteries were 6.78 and 20.9 mm2, respectively. The ratio of the nephrogram areas calculated from the arteriograms ranged from 0.094 to 0.809. Bland-Altman analysis showed no significant difference. Conclusion. It is possible to predict the supply volume of accessory renal arteries by measuring the cross-sectional area of the accessory and main renal arteries in potential living renal donors. © 2006 Japan Radiological Society.
    2006年04月, Radiation Medicine - Medical Imaging and Radiation Oncology, 24(3) (3), 195 - 201, 英語
    研究論文（学術雑誌）

  • M Hori, T Murakami, T Kim, R Iannaccone, H Abe, H Onishi, K Tomoda, C Catalano, R Passariello, H Nakamura
    Purpose: To investigate the role of ferucarbotran-enhanced. dynamic MR imaging using multishot spin-echo echo-planar sequence in the evaluation of hemodynamics of focal hepatic lesions. Materials and Methods: Sixty-three focal hepatic lesions (24 benign and 39 malignant) from 53 consecutive patients who underwent both ferucarbotran-enhanced MR imaging and dynamic computed tomography (CT) were included fit this study. MR imaging was performed with a 1.5-T scanner with a phased-array coil. T2-weighted multishot spin-echo echo-planar sequences (TR/TE = 1714-2813/80 msec) were obtained during a single breathhold before and 15, 60, 120, 180, and 600 seconds after intravenous injection of ferucarbotran. The enhancement patterns of lesions were classified into three categories by a study coordinator on the basis of dynamic CT images as hypervascular, hypovascular. and hemangioma type. The study coordinator created mean contrast-to-noise ratio of lesions vs. time curves for each enhancement pattern for quantitative analyses. Moreover, three radiologists separately and blindly reviewed MR images. and then assigned three confidence scores for the three enhancement patterns to each lesion. Sensitivity. specificity, and receiver operating characteristic analyses were performed. Results: Quantitative analyses showed characteristic enhancement Curves for each enhancement pattern. Mean sensitivities/specificities were 0.816/0.882, 0.897/0.863, and 0.800/0.989 for hypervascular, hypovascular, and hemangioma types, respectively. Mean areas under the receiver operating characteristic curve were 0.886 for hypervascular type and 0.913 for hypovascular type. Conclusion: Ferucarbotran-enhanced dynamic MR imaging can be used to successfully characterize the hemodynamics of focal hepatic lesions.
    JOHN WILEY & SONS INC, 2006年04月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 23(4) (4), 509 - 519, 英語
    研究論文（学術雑誌）

  • H Onishi, T Murakami, T Kim, M Hori, R Iannaccone, M Kuwabara, H Abe, S Nakata, K Osuga, K Tomoda, R Passariello, H Nakamura
    Purpose: To retrospectively compare the accuracy in detection of hepatic metastases among contrast material-enhanced multi-detector row computed tomography (CT) alone, superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging alone, and a combination of contrast-enhanced CT and SPIO-enhanced MR imaging. Material and Methods: The ethics committee did not require its approval or informed consent for this retrospective study, which was compliant with Declaration of Helsinki principles. Data in 38 patients (22 men, 16 women; mean age, 64.5 years: range, 35-78 years) suspected of having hepatic metastases who underwent both contrast-enhanced CT and SPIO-enhanced MR imaging were retrospectively analyzed. Twenty-one of the 38 patients had 61 metastases. Seventeen of the 61 metastases were confirmed histologically; the remaining 44 metastases were defined with imaging follow-up. At MR imaging, SPIO-enhanced heavily T1-weighted images, T2*-weighted gradient echo images, and T2-weighted fast spin-echo images were evaluated. Contrast-enhanced multi-detector row CT images obtained in the portal phase were evaluated. Four blinded observers independently reviewed CT images, MR images. Diagnostic accuracy was evaluated by using the alternative free-response receiver operating characteristic (AFROC) method. Sensitivities and positive predictive values were also analyzed with the Fisher protected least significant difference test and generalized estimating equations. Results: The mean area under the AFROC curve for the combined approach (0.70) was significantly higher than that for SPIO-enhanced MR imaging alone (0.58. P < .05, Fisher protected least significant difference test), and there was no significant difference between each of them and that for contrast-enhanced CT alone (0.66). For all lesions, the mean sensitivity of combined imaging (0.59) was significantly higher than that of CT (0.48) or MR imaging (0.43) alone (P < .05, Fisher protected least significant difference test and generalized estimating equations). For all lesions, the mean positive predictive values were 0.82, 0.89, and 0.81, for combined MR and CT, CT alone, and MR alone, respectively. Conclusion: The addition of SPIO-enhanced MR imaging to contrast-enhanced multi-detector row CT (ie, combined analysis of SPIO-enhanced MR images and contrast-enhanced CT images) can improve sensitivity in the detection of hepatic metastases, although this improvement in sensitivity was not significant at AFROC analysis. (c) RSNA 2006.
    RADIOLOGICAL SOC NORTH AMERICA, 2006年04月, RADIOLOGY, 239(1) (1), 131 - 138, 英語
    [査読有り]
    研究論文（学術雑誌）

  • N Tanigawa, A Komemushi, S Kariya, H Kojima, Y Shomura, K Ikeda, N Omura, T Murakami, S Sawada
    Purpose: To prospectively investigate the relationship between initial clinical response and bone marrow edema pattern on preprocedural magnetic resonance (MR) images in vertebral bodies selected For percutaneous vertebroplasty (PVP). Materials and Institutional review board approval and written informed Methods: consent were obtained. PVP was performed for osteoporotic compression fractures in 80 consecutive patients (mean age. 72.4 years: range. 44-85 years : 67 women and 14 men: 157 vertebrae). Patients were divided into three groups according to the proportion of the vertebra in which the bone marrow edema pattern was observed on sagittal MR images: group 1.50% or more of the vertebra; group 2, less than 50%; group 3. no edema pattern observed. By using Wilcoxon rank sum test, Fisher exact test.. and Wilcoxon signed rank test. groups were examined for differences in treatment efficacy, which was defined as the difference between preprocedural and postprocedural pain as assessed by means Of visual analog scale (VAS) score at 1-3 days after PVP. Results: Forty-four patients were assigned to group 1, 14 to group 2, and 22 to group 3. No significant difference was seen between the groups with respect to age. sex. number of treated vertebrae, or preprocedural VAS score. In group 1, VAS score decreased from 7.5 before the procedure to 2.9 after (improvement of 4.6). In group 2. the score decreased front 6.8 to 3.1 (improvement. or 3.7). fit group 3, the score decreased from 7.0 to 4.3 (improvement of 2.7). Improvement was significantly greater in group than in group 3 (P <.005). Conclusion: PVP resulted in significantly greater clinical improvement in patients with an extensive bone marrow edema pattern than it) those without this pattern. (c) RSNA, 2006.
    RADIOLOGICAL SOC NORTH AMERICA, 2006年04月, RADIOLOGY, 239(1) (1), 195 - 200, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M Hori, T Murakami, T Kim, R Iannaccone, H Abe, H Onishi, K Tomoda, C Catalano, R Passariello, H Nakamura
    Purpose: To investigate the role of ferucarbotran-enhanced. dynamic MR imaging using multishot spin-echo echo-planar sequence in the evaluation of hemodynamics of focal hepatic lesions. Materials and Methods: Sixty-three focal hepatic lesions (24 benign and 39 malignant) from 53 consecutive patients who underwent both ferucarbotran-enhanced MR imaging and dynamic computed tomography (CT) were included fit this study. MR imaging was performed with a 1.5-T scanner with a phased-array coil. T2-weighted multishot spin-echo echo-planar sequences (TR/TE = 1714-2813/80 msec) were obtained during a single breathhold before and 15, 60, 120, 180, and 600 seconds after intravenous injection of ferucarbotran. The enhancement patterns of lesions were classified into three categories by a study coordinator on the basis of dynamic CT images as hypervascular, hypovascular. and hemangioma type. The study coordinator created mean contrast-to-noise ratio of lesions vs. time curves for each enhancement pattern for quantitative analyses. Moreover, three radiologists separately and blindly reviewed MR images. and then assigned three confidence scores for the three enhancement patterns to each lesion. Sensitivity. specificity, and receiver operating characteristic analyses were performed. Results: Quantitative analyses showed characteristic enhancement Curves for each enhancement pattern. Mean sensitivities/specificities were 0.816/0.882, 0.897/0.863, and 0.800/0.989 for hypervascular, hypovascular, and hemangioma types, respectively. Mean areas under the receiver operating characteristic curve were 0.886 for hypervascular type and 0.913 for hypovascular type. Conclusion: Ferucarbotran-enhanced dynamic MR imaging can be used to successfully characterize the hemodynamics of focal hepatic lesions.
    JOHN WILEY & SONS INC, 2006年04月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 23(4) (4), 509 - 519, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masatomo Kuwabara, Yoshifumi Narumi, Satoru Takahashi, Yoshinobu Sato, Tonsok Kim, Takamichi Murakami, Hironobu Nakamura
    Purpose. The aim of this study was to evaluate the correlation between the renal artery cross-sectional area measured by multidetector computed tomography (MDCT) and the nephrogram area calculated by renal arteriography in potential living renal donors with duplicated renal arteries. Materials and methods. Medical records of 18 patients with duplicated renal arteries who underwent both MDCT angiography and renal arteriography between 2001 and 2003 were retrospectively reviewed. All 20 kidneys were evaluated. Renal artery cross-sectional areas were measured using the workstation to which the CT data were transferred the nephrogram areas on the digitized angiographic images were calculated using public domain software. Bland-Altman analysis was performed to compare the cross-sectional area ratio of the accessory arteries to the main renal arteries, with the ratios obtained from the nephrogram areas calculated from the arteriograms. Results. The mean cross-sectional areas of the accessory and main renal arteries were 6.78 and 20.9 mm2, respectively. The ratio of the nephrogram areas calculated from the arteriograms ranged from 0.094 to 0.809. Bland-Altman analysis showed no significant difference. Conclusion. It is possible to predict the supply volume of accessory renal arteries by measuring the cross-sectional area of the accessory and main renal arteries in potential living renal donors. © 2006 Japan Radiological Society.
    3, 2006年04月, Radiation Medicine - Medical Imaging and Radiation Oncology, 24(3) (3), 195 - 201, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 肝癌治療におけるReal-time Virtual Sonography(RVS)の有用性
    北田 学利, 村上 卓道, 松田 高明, 中城 和也, 南谷 かおり, 桜井 康介, 大須賀 慶吾, 三善 英知, 田村 信司, 中村 仁信, 林 紀夫, 岸野 文一郎
    (一社)日本肝臓学会, 2006年04月, 肝臓, 47(Suppl.1) (Suppl.1), A67 - A67, 日本語

  • Usefulness of the real-time virtual sonography on radiofrequency ablation of heparocellular carcinomas
    Takatoshi Kitada, Takamichi Murakami, Takaaki Matsuda, Kaori Minamitani, Kosuke Sakurai, Keigo Osuga, Noriyoshi Kuzushita, E. J. Miyoshi, Shinji Tamura, Hironobu Nakamura, Norio Hayashi, Bunichiro Kishino
    W B SAUNDERS CO-ELSEVIER INC, 2006年04月, GASTROENTEROLOGY, 130(4) (4), A775 - A775, 英語
    [査読有り]

  • T Murakami, H Onishi, K Mikami, R Iannaccone, MP Federle, T Kim, M Hori, A Okada, T Marukawa, H Higashihara, R Passariello, H Nakamura
    Objective: To find the optimal scan timing for early arterial phase hepatic CT with adequate arterial enhancement after the aortic contrast arrival. Methods: Sixty patients were divided randomly into three groups, each of which received 2.0 mL/kg of the 300 mgI/mL contrast medium with an injection duration of 30 seconds (Group A, mean rate 3.6 mL/sec); of 25 seconds (13, 4.6 mL/sec); of 30 seconds (3.6 mL/sec) followed by a saline chaser (C). Results: After the contrast arrival, aortic enhancement increased rapidly for 6-15 seconds (mean, 10 seconds) to the initial peak enhancement in all groups, and then, increased moderately to the maximum aortic enhancement over the following 19, 13, and 21 seconds, respectively. The mean maximum aortic enhancement in Group B (392 HU) and C (360 HU) were significantly higher than that in A (326 HU), respectively. The difference between the initial and maximum aortic enhancement was less than 50 HU. Conclusion: The optimal timing of the early arterial phase for hepatic CT arteriography is 10-15 seconds after the aortic arrival.
    LIPPINCOTT WILLIAMS & WILKINS, 2006年03月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 30(2) (2), 206 - 211, 英語
    研究論文（学術雑誌）

  • 太田英夫, 村上 卓道
    2006年03月, 肝臓, 47, 152 - 160

  • T Murakami, H Onishi, K Mikami, R Iannaccone, MP Federle, T Kim, M Hori, A Okada, T Marukawa, H Higashihara, R Passariello, H Nakamura
    Objective: To find the optimal scan timing for early arterial phase hepatic CT with adequate arterial enhancement after the aortic contrast arrival. Methods: Sixty patients were divided randomly into three groups, each of which received 2.0 mL/kg of the 300 mgI/mL contrast medium with an injection duration of 30 seconds (Group A, mean rate 3.6 mL/sec); of 25 seconds (13, 4.6 mL/sec); of 30 seconds (3.6 mL/sec) followed by a saline chaser (C). Results: After the contrast arrival, aortic enhancement increased rapidly for 6-15 seconds (mean, 10 seconds) to the initial peak enhancement in all groups, and then, increased moderately to the maximum aortic enhancement over the following 19, 13, and 21 seconds, respectively. The mean maximum aortic enhancement in Group B (392 HU) and C (360 HU) were significantly higher than that in A (326 HU), respectively. The difference between the initial and maximum aortic enhancement was less than 50 HU. Conclusion: The optimal timing of the early arterial phase for hepatic CT arteriography is 10-15 seconds after the aortic arrival.
    LIPPINCOTT WILLIAMS & WILKINS, 2006年03月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 30(2) (2), 206 - 211, 英語
    [査読有り]
    研究論文（学術雑誌）

  • GISTのイマチニブ治療に対する耐性・再進行の診断 CTとPETの比較
    金 東石, 坪山 尚寛, 村上 卓道, 堀 雅敏, 大西 裕満, 友田 要, 西田 俊朗, 中村 仁信
    (公社)日本医学放射線学会, 2006年02月, 日本医学放射線学会学術集会抄録集, 65回, S298 - S298, 日本語

  • T Yasumoto, T Murakami, H Yamamoto, M Hori, R Iannaccone, T Kim, H Abe, M Kuwabara, K Yamasaki, N Kikkawa, H Arimoto, R Passariello, H Nakamura
    OBJECTIVE. The objective of our study was to assess the value of two-way interpretation (i.e., from rectum to cecum and vice versa) compared with one-way interpretation (i.e., from rectum to cecum only) in terms of polyp detection and interpretation time on MDCT colonography. MATERIALS AND METHODS. Fifty consecutive patients underwent both CT colonography and conventional colonoscopy. Three radiologists independently analyzed the CT colonographic examinations of each patient using a primary 3D method. All examinations were analyzed using two techniques: navigation from rectum to cecum only (one-way) and navigation from rectum to cecum and vice versa (two-way). Sensitivity and positive predictive value were calculated on both a per-polyp basis and a per-patient basis. Alternative free-response receiver operating characteristic (ROC) curve analysis was estimated, and image interpretation time was documented. RESULTS. One hundred fifty-five polyps were depicted in 45 patients by colonoscopy. The mean sensitivity of CT colonography for polyp detection with two-way (88.4%) was significantly superior to that with one-way (78.1%) (p < 0.01). The mean positive predictive value of each observer with one-way was 66.7%, whereas that with two-way was 65.8%. The mean area under the alternative free-response ROC curve (A(z) value) with two-way (0.827) was higher than that with one-way (0.816), but there was not a statistically significant difference. The average interpretation time of each observer with two-way (39 min) was statistically significantly longer than that with one-way (25 min) (p < 0.01). CONCLUSION. When using a primary 3D interpretation technique at CT colonography, complete 3D navigation from rectum to cecum and from cecum to rectum is mandatory to maximize polyp detection. The image interpretation time for two-way interpretation is statistically significantly longer than that with one-way interpretation.
    AMER ROENTGEN RAY SOC, 2006年01月, AMERICAN JOURNAL OF ROENTGENOLOGY, 186(1) (1), 85 - 89, 英語
    研究論文（学術雑誌）

  • S Kumano, T Murakami, T Kim, M Hori, R Iannaccone, S Nakata, H Onishi, K Osuga, K Tomoda, C Catalano, H Nakamura
    PURPOSE: To evaluate retrospectively the accuracy of multi-detector row computed tomography (CT) in the assessment of serosal invasion in patients with gastric cancer. MATERIALS AND METHODS: The Ethics Committee does not require approval or informed consent for retrospective studies. Forty-one consecutive patients (24 men, 17 women; mean age, 68 years) with gastric cancer were included in this study. All patients were given 600 mL of tap water to drink and were positioned prone or supine on the scanning table. The detector row configuration included four detector rows, a section thickness of 1.25 mm, a pitch of 6, and a reconstruction interval of 0.63 mm. Transverse and multiplanar reconstruction images were simultaneously evaluated by two independent observers to assess the depth of tumor invasion in the gastric wall (ie, T stage). T staging at multi-detector row CT was compared with T staging at histologic evaluation (reference standard), which was performed by means of surgical or histologic examination of the resected specimen. We also calculated the sensitivity, specificity, and accuracy of multi-detector row CT for each observer in the assessment of serosal invasion. RESULTS: Analysis of interobserver agreement showed substantial or almost perfect agreement (nonweighted kappa value of 0.78 and weighted kappa value of 0.85). Correct assessment of gastric wall invasion was 80% and 85% for observers 1 and 2, respectively. The sensitivity, specificity, and accuracy of multi-detector row CT in the assessment of serosal invasion were 90%, 95%, and 93%, respectively, for observer 1 and 80%, 97%, and 93%, respectively, for observer 2. Overstaging occurred in six patients, and understaging occurred in five patients. All understaged tumors were scirrhous subtype gastric cancer. CONCLUSION: Multi-detector row CT scanning of patients with gastric cancer gave 93% accuracy in the assessment of serosal invasion in patients with gastric cancer. (c) RSNA, 2005.
    RADIOLOGICAL SOC NORTH AMERICA, 2006年01月, RADIOLOGY, 237(3) (3), 961 - 966, 英語
    研究論文（学術雑誌）

  • Masatoshi Hori, Tonsok Kim, Takamichi Murakami, Hiromitsu Onishi, Naohiro Tsuboyama, Keigo Osuga, Kaname Tomoda, Hironobu Nakamura, Masaya Hirano, Atsushi Nozaki
    A tetrahedral gradient diffusion sequence for body imaging for a 1.5T scanner was implemented, and we compared the quality of images acquired with the new technique and with the conventional orthogonal technique. Image quality was better using the tetrahedral technique in terms of signal homogeneity in the right liver lobe and signal loss artifact in the left lobe, and the technique was considered useful for magnetic resonance imaging in the upper abdomen.
    2006年, Magnetic Resonance in Medical Sciences, 5(4) (4), 201 - 206, 英語
    研究論文（学術雑誌）

  • Atsuya Okada, Takamichi Murakami, Koji Mikami, Hiromitsu Onishi, Noboru Tanigawa, Taro Marukawa, Hironobu Nakamura
    Focused ultrasound surgery (FUS) is a method of noninvasive focal thermal ablation. Temperature-sensitive phase-difference magnetic resonance (MR) imaging allows monitoring of the focal point and measurement of tissue temperature elevation in real time, ensuring delivery of a therapeutic dose. A newly developed respiratory monitoring system enables us to track liver tumors, which move with respiration. We report our initial experience using MR-guided FUS with respiratory gating in successfully treating a hepatocellular carcinoma 15 mm in diameter.
    2006年, Magnetic Resonance in Medical Sciences, 5(3) (3), 167 - 171, 英語
    研究論文（学術雑誌）

  • S Kumano, T Murakami, T Kim, M Hori, R Iannaccone, S Nakata, H Onishi, K Osuga, K Tomoda, C Catalano, H Nakamura
    PURPOSE: To evaluate retrospectively the accuracy of multi-detector row computed tomography (CT) in the assessment of serosal invasion in patients with gastric cancer. MATERIALS AND METHODS: The Ethics Committee does not require approval or informed consent for retrospective studies. Forty-one consecutive patients (24 men, 17 women; mean age, 68 years) with gastric cancer were included in this study. All patients were given 600 mL of tap water to drink and were positioned prone or supine on the scanning table. The detector row configuration included four detector rows, a section thickness of 1.25 mm, a pitch of 6, and a reconstruction interval of 0.63 mm. Transverse and multiplanar reconstruction images were simultaneously evaluated by two independent observers to assess the depth of tumor invasion in the gastric wall (ie, T stage). T staging at multi-detector row CT was compared with T staging at histologic evaluation (reference standard), which was performed by means of surgical or histologic examination of the resected specimen. We also calculated the sensitivity, specificity, and accuracy of multi-detector row CT for each observer in the assessment of serosal invasion. RESULTS: Analysis of interobserver agreement showed substantial or almost perfect agreement (nonweighted kappa value of 0.78 and weighted kappa value of 0.85). Correct assessment of gastric wall invasion was 80% and 85% for observers 1 and 2, respectively. The sensitivity, specificity, and accuracy of multi-detector row CT in the assessment of serosal invasion were 90%, 95%, and 93%, respectively, for observer 1 and 80%, 97%, and 93%, respectively, for observer 2. Overstaging occurred in six patients, and understaging occurred in five patients. All understaged tumors were scirrhous subtype gastric cancer. CONCLUSION: Multi-detector row CT scanning of patients with gastric cancer gave 93% accuracy in the assessment of serosal invasion in patients with gastric cancer. (c) RSNA, 2005.
    RADIOLOGICAL SOC NORTH AMERICA, 2006年01月, RADIOLOGY, 237(3) (3), 961 - 966, 英語
    [査読有り]
    研究論文（学術雑誌）

  • T Yasumoto, T Murakami, H Yamamoto, M Hori, R Iannaccone, T Kim, H Abe, M Kuwabara, K Yamasaki, N Kikkawa, H Arimoto, R Passariello, H Nakamura
    OBJECTIVE. The objective of our study was to assess the value of two-way interpretation (i.e., from rectum to cecum and vice versa) compared with one-way interpretation (i.e., from rectum to cecum only) in terms of polyp detection and interpretation time on MDCT colonography. MATERIALS AND METHODS. Fifty consecutive patients underwent both CT colonography and conventional colonoscopy. Three radiologists independently analyzed the CT colonographic examinations of each patient using a primary 3D method. All examinations were analyzed using two techniques: navigation from rectum to cecum only (one-way) and navigation from rectum to cecum and vice versa (two-way). Sensitivity and positive predictive value were calculated on both a per-polyp basis and a per-patient basis. Alternative free-response receiver operating characteristic (ROC) curve analysis was estimated, and image interpretation time was documented. RESULTS. One hundred fifty-five polyps were depicted in 45 patients by colonoscopy. The mean sensitivity of CT colonography for polyp detection with two-way (88.4%) was significantly superior to that with one-way (78.1%) (p < 0.01). The mean positive predictive value of each observer with one-way was 66.7%, whereas that with two-way was 65.8%. The mean area under the alternative free-response ROC curve (A(z) value) with two-way (0.827) was higher than that with one-way (0.816), but there was not a statistically significant difference. The average interpretation time of each observer with two-way (39 min) was statistically significantly longer than that with one-way (25 min) (p < 0.01). CONCLUSION. When using a primary 3D interpretation technique at CT colonography, complete 3D navigation from rectum to cecum and from cecum to rectum is mandatory to maximize polyp detection. The image interpretation time for two-way interpretation is statistically significantly longer than that with one-way interpretation.
    AMER ROENTGEN RAY SOC, 2006年01月, AMERICAN JOURNAL OF ROENTGENOLOGY, 186(1) (1), 85 - 89, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Atsuya Okada, Takamichi Murakami, Koji Mikami, Hiromitsu Onishi, Noboru Tanigawa, Taro Marukawa, Hironobu Nakamura
    Focused ultrasound surgery (FUS) is a method of noninvasive focal thermal ablation. Temperature-sensitive phase-difference magnetic resonance (MR) imaging allows monitoring of the focal point and measurement of tissue temperature elevation in real time, ensuring delivery of a therapeutic dose. A newly developed respiratory monitoring system enables us to track liver tumors, which move with respiration. We report our initial experience using MR-guided FUS with respiratory gating in successfully treating a hepatocellular carcinoma 15 mm in diameter.
    3, 2006年, Magnetic Resonance in Medical Sciences, 5(3) (3), 167 - 171, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masatoshi Hori, Tonsok Kim, Takamichi Murakami, Hiromitsu Onishi, Naohiro Tsuboyama, Keigo Osuga, Kaname Tomoda, Hironobu Nakamura, Masaya Hirano, Atsushi Nozaki
    A tetrahedral gradient diffusion sequence for body imaging for a 1.5T scanner was implemented, and we compared the quality of images acquired with the new technique and with the conventional orthogonal technique. Image quality was better using the tetrahedral technique in terms of signal homogeneity in the right liver lobe and signal loss artifact in the left lobe, and the technique was considered useful for magnetic resonance imaging in the upper abdomen.
    4, 2006年, Magnetic Resonance in Medical Sciences, 5(4) (4), 201 - 206, 英語
    [査読有り]
    研究論文（学術雑誌）

  • R Iannaccone, C Catalano, F Mangiapane, T Murakami, A Lamazza, E Fiori, A Schillaci, D Marin, Nofroni, I, M Hori, R Passariello
    PURPOSE: To prospectively evaluate the diagnostic accuracy of low-radiation-close computed tomographic (CT) colonography for detection of colorectal polyps by using two sequential colonoscopies, with the second colonoscopy as the reference standard. MATERIALS AND METHODS: The study was local ethics committee approved, and all patients gave written informed consent. Colonographic images were acquired by using a low-dose multi-detector row CT protocol (effective milliampere-second setting, 10 mAs). Three observers interpreted the CT colonographic data separately and independently by using a two-dimensional technique. Initial conventional colonoscopy was performed by an endoscopist unaware of the CT colonographic findings. Second colonoscopy performed within 2 weeks by a colonoscopist aware of both the CT colonographic and the initial colonoscopic findings served as the reference standard. The sensitivities of CT colonography and initial colonoscopy were calculated on a per-polyp and a per-patient basis. Specificities and positive and negative predictive values also were calculated on a per-patient basis. RESULTS: Eighty-eight patients underwent CT colonography and initial conventional colonoscopy on the same day. Per-polyp sensitivities were 62% and 83% for CT colonography and initial colonoscopy, respectively. Sensitivities for detection of polyps 6 mm in diameter or larger were 86% and 84% for CT colonography and initial colonoscopy, respectively. Initial colonoscopy failed to depict 16 polyps, six of which were correctly detected with CT colonography. For identification of patients with polyps 6 mm in diameter or larger, CT colonography and initial colonoscopy, respectively, had sensitivities of 84% and 90%, specificities of 82% and 100%, positive predictive values of 70% and 100%, and negative predictive values of 91% and 95%. CONCLUSION: Low-dose CT colonography compares favorably with colonoscopy for detection of colorectal polyps 6 mm in diameter or larger, with markedly decreased performance for detection of polyps 5 mm in diameter or smaller. (c) RSNA, 2005.
    RADIOLOGICAL SOC NORTH AMERICA, 2005年12月, RADIOLOGY, 237(3) (3), 927 - 937, 英語
    研究論文（学術雑誌）

  • R Iannaccone, C Catalano, F Mangiapane, T Murakami, A Lamazza, E Fiori, A Schillaci, D Marin, Nofroni, I, M Hori, R Passariello
    PURPOSE: To prospectively evaluate the diagnostic accuracy of low-radiation-close computed tomographic (CT) colonography for detection of colorectal polyps by using two sequential colonoscopies, with the second colonoscopy as the reference standard. MATERIALS AND METHODS: The study was local ethics committee approved, and all patients gave written informed consent. Colonographic images were acquired by using a low-dose multi-detector row CT protocol (effective milliampere-second setting, 10 mAs). Three observers interpreted the CT colonographic data separately and independently by using a two-dimensional technique. Initial conventional colonoscopy was performed by an endoscopist unaware of the CT colonographic findings. Second colonoscopy performed within 2 weeks by a colonoscopist aware of both the CT colonographic and the initial colonoscopic findings served as the reference standard. The sensitivities of CT colonography and initial colonoscopy were calculated on a per-polyp and a per-patient basis. Specificities and positive and negative predictive values also were calculated on a per-patient basis. RESULTS: Eighty-eight patients underwent CT colonography and initial conventional colonoscopy on the same day. Per-polyp sensitivities were 62% and 83% for CT colonography and initial colonoscopy, respectively. Sensitivities for detection of polyps 6 mm in diameter or larger were 86% and 84% for CT colonography and initial colonoscopy, respectively. Initial colonoscopy failed to depict 16 polyps, six of which were correctly detected with CT colonography. For identification of patients with polyps 6 mm in diameter or larger, CT colonography and initial colonoscopy, respectively, had sensitivities of 84% and 90%, specificities of 82% and 100%, positive predictive values of 70% and 100%, and negative predictive values of 91% and 95%. CONCLUSION: Low-dose CT colonography compares favorably with colonoscopy for detection of colorectal polyps 6 mm in diameter or larger, with markedly decreased performance for detection of polyps 5 mm in diameter or smaller. (c) RSNA, 2005.
    RADIOLOGICAL SOC NORTH AMERICA, 2005年12月, RADIOLOGY, 237(3) (3), 927 - 937, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Prospective respiratory-triggered multidetector row CT (MDCT) for abdominal examinations: Initial experience with a prototype
    Markus Fahrni, Takamichi Murakami, Masatoshi Hori, Tonsok Kim, Toru Matsumura, Masayuki Kudo, Shigeru Sase, Kaname Tomoda, Hironobu Nakamura
    Purpose: To develop a prototype for prospective respiratory-triggered multidetector row computed tomography (MDCT) for abdominal examinations and to assess its feasibility. Materials and Methods: The prototype consisted of the following components: an MDCT unit, personal computer (PC), and a respiratory motion detector in the form of a wearable belt with sensors to measure differences in pressure caused by breathing excursions. The registered signals were processed by the PC. The abdominal MDCT images of 10 healthy volunteers were obtained with an incremental axial technique in the expiration phase during normal breathing. Multiplanar reformations (MPR) were then performed. On the basis of the precision of these reconstructions, two radiologists then assessed the accuracy and applicability of the system. Results: Coronal and sagittal MPR images from these prospective respiratory-gated examinations were found to be accurate. In particular, the continuity of borders and surfaces of scanned organs proved the exactness of the previously acquired respiration-correlated axial source images. Conclusion: This prototype is feasible to perform prospective respiratory-triggered abdominal MDCT examinations during normal respiration without breathhold. This system may be useful for patients with reduced compliance in holding their breath.
    2005年11月, Radiation Medicine - Medical Imaging and Radiation Oncology, 23(7) (7), 528 - 531, 英語
    研究論文（学術雑誌）

  • S Hayashi, K Dono, J Shimizu, T Murakami, M Takamura, T Kim, M Hori, ZH Lu, H Nagano, S Nakamori, M Sakon, H Nakamura, M Monden
    Background. A new Xenon computed tomography (CT) system was developed to measure both hepatic arterial and portal venous tissue blood flow (HATBF/ PVTBF) non-invasively. Despite its clinical trial, the effect of prostaglandin El (PGE1) on hepatic hemodynamics is not well investigated. In a rabbit model, we evaluated the accuracy of this system by comparing it with the electromagnetic blood flowmeter (EMBF), the pharmacological effect of PGE1 on the fractional hepatic hemodynamics. Materials and methods. Seven NZW-rabbits were used. Serial abdominal CT scan was obtained every min before and during the 4 min inhalation of the Xenon gas, followed by 5 min administration of oxygen air. From these images, HATBF and PVTBF were separately calculated with a special new imaging system. We also used EMBF during laparotomy, and directly measured the hepatic arterial and portal venous flow with or without PGE1 administration. Results. Xenon CT showed HATBF of 18.4 +/- 4.5 (ml/min/100 g) and PVTBF of 69.4 +/- 15.0, was almost identical with those of EMBF (19.8 +/- 5.7 and 67.2 +/- 19.1, respectively). After PGE1 administration, Xenon CT showed 22.9 +/- 4.6 and 76.5 +/- 20.5, while those with EMBF were 21.0 +/- 6.5 and 84.7 +/- 21.6, respectively. There were significant correlations (P < 0.01) in total HTBF, HATBF, and PVTBF between results of Xenon CT and EMBF. Conclusions. Xenon CT with a newly developed imaging system enables us to measure the fractional hepatic tissue blood flow in rabbits, differentially and accurately. Venous administration of PGE1 increased total hepatic blood flow, mainly affecting the portal blood flow. (c) 2005 Elsevier Inc. All rights reserved.
    ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005年11月, JOURNAL OF SURGICAL RESEARCH, 129(1) (1), 24 - 30, 英語
    研究論文（学術雑誌）

  • S Hayashi, K Dono, J Shimizu, T Murakami, M Takamura, T Kim, M Hori, ZH Lu, H Nagano, S Nakamori, M Sakon, H Nakamura, M Monden
    Background. A new Xenon computed tomography (CT) system was developed to measure both hepatic arterial and portal venous tissue blood flow (HATBF/ PVTBF) non-invasively. Despite its clinical trial, the effect of prostaglandin El (PGE1) on hepatic hemodynamics is not well investigated. In a rabbit model, we evaluated the accuracy of this system by comparing it with the electromagnetic blood flowmeter (EMBF), the pharmacological effect of PGE1 on the fractional hepatic hemodynamics. Materials and methods. Seven NZW-rabbits were used. Serial abdominal CT scan was obtained every min before and during the 4 min inhalation of the Xenon gas, followed by 5 min administration of oxygen air. From these images, HATBF and PVTBF were separately calculated with a special new imaging system. We also used EMBF during laparotomy, and directly measured the hepatic arterial and portal venous flow with or without PGE1 administration. Results. Xenon CT showed HATBF of 18.4 +/- 4.5 (ml/min/100 g) and PVTBF of 69.4 +/- 15.0, was almost identical with those of EMBF (19.8 +/- 5.7 and 67.2 +/- 19.1, respectively). After PGE1 administration, Xenon CT showed 22.9 +/- 4.6 and 76.5 +/- 20.5, while those with EMBF were 21.0 +/- 6.5 and 84.7 +/- 21.6, respectively. There were significant correlations (P < 0.01) in total HTBF, HATBF, and PVTBF between results of Xenon CT and EMBF. Conclusions. Xenon CT with a newly developed imaging system enables us to measure the fractional hepatic tissue blood flow in rabbits, differentially and accurately. Venous administration of PGE1 increased total hepatic blood flow, mainly affecting the portal blood flow. (c) 2005 Elsevier Inc. All rights reserved.
    ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005年11月, JOURNAL OF SURGICAL RESEARCH, 129(1) (1), 24 - 30, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Prospective respiratory-triggered multidetector row CT (MDCT) for abdominal examinations: Initial experience with a prototype
    Markus Fahrni, Takamichi Murakami, Masatoshi Hori, Tonsok Kim, Toru Matsumura, Masayuki Kudo, Shigeru Sase, Kaname Tomoda, Hironobu Nakamura
    Purpose: To develop a prototype for prospective respiratory-triggered multidetector row computed tomography (MDCT) for abdominal examinations and to assess its feasibility. Materials and Methods: The prototype consisted of the following components: an MDCT unit, personal computer (PC), and a respiratory motion detector in the form of a wearable belt with sensors to measure differences in pressure caused by breathing excursions. The registered signals were processed by the PC. The abdominal MDCT images of 10 healthy volunteers were obtained with an incremental axial technique in the expiration phase during normal breathing. Multiplanar reformations (MPR) were then performed. On the basis of the precision of these reconstructions, two radiologists then assessed the accuracy and applicability of the system. Results: Coronal and sagittal MPR images from these prospective respiratory-gated examinations were found to be accurate. In particular, the continuity of borders and surfaces of scanned organs proved the exactness of the previously acquired respiration-correlated axial source images. Conclusion: This prototype is feasible to perform prospective respiratory-triggered abdominal MDCT examinations during normal respiration without breathhold. This system may be useful for patients with reduced compliance in holding their breath.
    7, 2005年11月, Radiation Medicine - Medical Imaging and Radiation Oncology, 23(7) (7), 528 - 531, 英語
    [査読有り]
    研究論文（学術雑誌）

  • [Radiofrequency ablation for hepatocellular carcinoma and liver metastases].
    Yasumoto T, Murakami T, Katsumoto Y, Hashimoto T, Noda S, Murata K, Kinuta M, Nakamura H
    11, 2005年10月, Gan to kagaku ryoho. Cancer & chemotherapy, 32, 1596 - 1599
    [査読有り]

  • [Successful treatment of combined intraarterial (5-fluorouracil and adriamycin and cisplatin) infusion chemotherapy for advanced hepatocellular carcinoma with multiple intrahepatic metastases and/or portal vein thrombosis--two case reports].
    Kato H, Nagano H, Ota H, Nakamura M, Wada H, Yoshioka S, Noda T, Bazarragchaa D, Marubashi S, Miyamoto A, Takeda Y, Umeshita K, Dono K, Murakami T, Nakamura H, Monden M
    11, 2005年10月, Gan to kagaku ryoho. Cancer & chemotherapy, 32, 1842 - 1845
    [査読有り]

  • Quantitative tissue blood flow evaluation of pancreatic tumor: Comparison between xenon CT technique and perfusion CT technique based on deconvolution analysis
    Hisashi Abe, Takamichi Murakami, Masaru Kubota, Tonsok Kim, Masatoshi Hori, Masayuki Kudo, Kazuhiko Hashimoto, Shoji Nakamori, Keizo Dono, Kaname Tomoda, Morito Monden, Hironobu Nakamura
    Purpose: There has been one report that tissue blood flow (TBF) quantification with xenon CT was effective in predicting the therapeutic response to an anticancer drug in pancreatic cancer. The purpose of this study was to evaluate the correlation between the TBF of pancreatic tumors calculated with xenon CT and those with perfusion CT, in order to evaluate whether perfusion CT could replace xenon CT. Materials and Methods: Nine patients with pathologically proved pancreatic tumors who underwent both xenon CT and perfusion CT were included. Results: Quantitative TBF of pancreatic tumors measured by perfusion CT ranged from 22.1 to 196.2 ml/min/100 g (mean±SD, 52.6±54.8 ml/min/100 g). In contrast, those obtained by xenon CT ranged from 10.3 to 173.6 ml/min/100 g (mean±SD, 47.9±49.4 ml/min/100 g). There was a good linear correlation between xenon CT and perfusion CT (y=0.8537x+2.48, R2=0.895: p< 0.05). Conclusion: The TBF of pancreatic tumors measured by xenon CT and perfusion CT techniques showed a close linear correlation. We can expect that perfusion CT based on the deconvolution algorithm may replace xenon CT to predict the effect of pancreatic tumor treatment with anticancer drugs.
    2005年08月, Radiation Medicine - Medical Imaging and Radiation Oncology, 23(5) (5), 364 - 370, 英語
    研究論文（学術雑誌）

  • Quantitative tissue blood flow evaluation of pancreatic tumor: Comparison between xenon CT technique and perfusion CT technique based on deconvolution analysis
    Hisashi Abe, Takamichi Murakami, Masaru Kubota, Tonsok Kim, Masatoshi Hori, Masayuki Kudo, Kazuhiko Hashimoto, Shoji Nakamori, Keizo Dono, Kaname Tomoda, Morito Monden, Hironobu Nakamura
    Purpose: There has been one report that tissue blood flow (TBF) quantification with xenon CT was effective in predicting the therapeutic response to an anticancer drug in pancreatic cancer. The purpose of this study was to evaluate the correlation between the TBF of pancreatic tumors calculated with xenon CT and those with perfusion CT, in order to evaluate whether perfusion CT could replace xenon CT. Materials and Methods: Nine patients with pathologically proved pancreatic tumors who underwent both xenon CT and perfusion CT were included. Results: Quantitative TBF of pancreatic tumors measured by perfusion CT ranged from 22.1 to 196.2 ml/min/100 g (mean±SD, 52.6±54.8 ml/min/100 g). In contrast, those obtained by xenon CT ranged from 10.3 to 173.6 ml/min/100 g (mean±SD, 47.9±49.4 ml/min/100 g). There was a good linear correlation between xenon CT and perfusion CT (y=0.8537x+2.48, R2=0.895: p< 0.05). Conclusion: The TBF of pancreatic tumors measured by xenon CT and perfusion CT techniques showed a close linear correlation. We can expect that perfusion CT based on the deconvolution algorithm may replace xenon CT to predict the effect of pancreatic tumor treatment with anticancer drugs.
    5, 2005年08月, Radiation Medicine - Medical Imaging and Radiation Oncology, 23(5) (5), 364 - 370, 英語
    [査読有り]
    研究論文（学術雑誌）

  • T Murakami, M Takamura, T Kim, M Hori, MP Federle, H Onishi, K Tomoda, H Nakamura
    Rationale and objectives: The purpose of this study is to assess the diagnostic impact of double phase computed tomography during hepatic arteriography for hepatocellular carcinoma. Materials and methods: 118 hepatocellular carcinomas in 73 cirrhotic patients who underwent double phase computed tomography during hepatic arteriography were enrolled in this study. Double phase computed tomography during hepatic arteriography consisted of computed tomography images obtained at 5-10 s (first phase) and 40-50 s (second phase) after the initiation of an intraarterial administration of 40-60 ml of contrast medium through the hepatic artery. Diagnostic accuracy of the first phase computed tomography during hepatic arteriography alone and double phase computed tomography during hepatic arteriography images for hepatocellular carcinoma were separately analyzed by three blinded readers independently. Alternative-free response receiver operating characteristic curves were constructed to compare each set of computed tomography during hepatic arteriography images. Results: The detection sensitivity of the double phase CTHA for HCC (mean, 83.1%) was significantly higher than that of the first phase CTHA alone (mean, 73.4%) (P < 0.01). Moreover. the positive predictive value of the double phase CTHA (mean, 93.7%) was higher than that of the first phase CTHA alone (87.4%). The area under the AFROC curve (Az value) of the double phase CTHA (mean, 0.88) was significantly higher than that of the first phase CTHA alone (mean, 0.77) (P < 0.05). Conclusions: Double phase computed tomography during hepatic arteriography can improve the diagnostic accuracy of hepatocellular carcinoma. © 2004 Elsevier Ireland Ltd. All rights reserved.
    ELSEVIER IRELAND LTD, 2005年05月, EUROPEAN JOURNAL OF RADIOLOGY, 54(2) (2), 246 - 252, 英語
    研究論文（学術雑誌）

  • T Murakami, M Takamura, T Kim, M Hori, MP Federle, H Onishi, K Tomoda, H Nakamura
    Rationale and objectives: The purpose of this study is to assess the diagnostic impact of double phase computed tomography during hepatic arteriography for hepatocellular carcinoma. Materials and methods: 118 hepatocellular carcinomas in 73 cirrhotic patients who underwent double phase computed tomography during hepatic arteriography were enrolled in this study. Double phase computed tomography during hepatic arteriography consisted of computed tomography images obtained at 5-10 s (first phase) and 40-50 s (second phase) after the initiation of an intraarterial administration of 40-60 ml of contrast medium through the hepatic artery. Diagnostic accuracy of the first phase computed tomography during hepatic arteriography alone and double phase computed tomography during hepatic arteriography images for hepatocellular carcinoma were separately analyzed by three blinded readers independently. Alternative-free response receiver operating characteristic curves were constructed to compare each set of computed tomography during hepatic arteriography images. Results: The detection sensitivity of the double phase CTHA for HCC (mean, 83.1%) was significantly higher than that of the first phase CTHA alone (mean, 73.4%) (P < 0.01). Moreover. the positive predictive value of the double phase CTHA (mean, 93.7%) was higher than that of the first phase CTHA alone (87.4%). The area under the AFROC curve (Az value) of the double phase CTHA (mean, 0.88) was significantly higher than that of the first phase CTHA alone (mean, 0.77) (P < 0.05). Conclusions: Double phase computed tomography during hepatic arteriography can improve the diagnostic accuracy of hepatocellular carcinoma. © 2004 Elsevier Ireland Ltd. All rights reserved.
    ELSEVIER IRELAND LTD, 2005年05月, EUROPEAN JOURNAL OF RADIOLOGY, 54(2) (2), 246 - 252, 英語
    [査読有り]
    研究論文（学術雑誌）

  • R Iannaccone, A Laghi, C Catalano, P Rossi, F Mangiapane, T Murakami, M Hori, F Piacentini, Nofroni, I, R Passariello
    PURPOSE: To determine, by using multi-detector row helical computed tomography (CT), the added value of obtaining unenhanced and delayed phase scans in addition to biphasic (hepatic arterial and portal venous phases) scans in the detection of hepatocellular carcinoma (HCC) in patients with cirrhosis. MATERIALS AND METHODS: Local ethical committee approval and patient consent were obtained. One hundred ninety-five patients (129 men, 66 women; mean age, 61 years; age range, 39-78 years) with 250 HCCs underwent multi-detector row helical CT of the liver. A quadruple-phase protocol that included unenhanced, hepatic arterial, portal venous, and delayed phases was performed. Analysis of images from hepatic arterial and portal venous phases combined, hepatic arterial and portal venous phases with the unenhanced phase, hepatic arterial and portal venous phases with the delayed phase, and all phases combined was performed separately by three independent radiologists. Relative sensitivity, positive predictive value, and area under the receiver operating characteristic curve (A,) were calculated for each reading session. RESULTS: Mean sensitivity and positive predictive values, respectively, for HCC detection were 88.8% (666 of 750 readings) and 97.8% (666 of 681 readings) for the combined hepatic arterial and portal venous phases, 89.2% (669 of 750 readings) and 97.8% (669 of 684 readings) for hepatic arterial and portal venous phases with the unenhanced phase, 92.8% (696 of 750 readings) and 97.3% (696 of 715 readings) for hepatic arterial and portal venous phases with the delayed phase, and 92.8% (696 of 750 readings) and 97.3% (696 of 715 readings) for all four phases combined. The reading sessions in which delayed phase images were available for interpretation showed significantly (P <.05) superior sensitivity and A, values. CONCLUSION: Unenhanced phase images are not effective for HCC detection. Because of the significant increase in HCC detection, a delayed phase can be a useful adjunct to biphasic CT in patients at risk for developing HCC.
    RADIOLOGICAL SOC NORTH AMERICA, 2005年02月, RADIOLOGY, 234(2) (2), 460 - 467, 英語
    研究論文（学術雑誌）

  • R Iannaccone, A Laghi, C Catalano, P Rossi, F Mangiapane, T Murakami, M Hori, F Piacentini, Nofroni, I, R Passariello
    PURPOSE: To determine, by using multi-detector row helical computed tomography (CT), the added value of obtaining unenhanced and delayed phase scans in addition to biphasic (hepatic arterial and portal venous phases) scans in the detection of hepatocellular carcinoma (HCC) in patients with cirrhosis. MATERIALS AND METHODS: Local ethical committee approval and patient consent were obtained. One hundred ninety-five patients (129 men, 66 women; mean age, 61 years; age range, 39-78 years) with 250 HCCs underwent multi-detector row helical CT of the liver. A quadruple-phase protocol that included unenhanced, hepatic arterial, portal venous, and delayed phases was performed. Analysis of images from hepatic arterial and portal venous phases combined, hepatic arterial and portal venous phases with the unenhanced phase, hepatic arterial and portal venous phases with the delayed phase, and all phases combined was performed separately by three independent radiologists. Relative sensitivity, positive predictive value, and area under the receiver operating characteristic curve (A,) were calculated for each reading session. RESULTS: Mean sensitivity and positive predictive values, respectively, for HCC detection were 88.8% (666 of 750 readings) and 97.8% (666 of 681 readings) for the combined hepatic arterial and portal venous phases, 89.2% (669 of 750 readings) and 97.8% (669 of 684 readings) for hepatic arterial and portal venous phases with the unenhanced phase, 92.8% (696 of 750 readings) and 97.3% (696 of 715 readings) for hepatic arterial and portal venous phases with the delayed phase, and 92.8% (696 of 750 readings) and 97.3% (696 of 715 readings) for all four phases combined. The reading sessions in which delayed phase images were available for interpretation showed significantly (P <.05) superior sensitivity and A, values. CONCLUSION: Unenhanced phase images are not effective for HCC detection. Because of the significant increase in HCC detection, a delayed phase can be a useful adjunct to biphasic CT in patients at risk for developing HCC.
    RADIOLOGICAL SOC NORTH AMERICA, 2005年02月, RADIOLOGY, 234(2) (2), 460 - 467, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 子宮筋腫に対するMRIガイド集束超音波治療における拡散強調画像の有用性
    礒橋 佳也子, 岡田 篤哉, 丸川 太朗, 三上 恒治, 村上 卓道, 中村 仁信, Keserci Bilgin
    (公社)日本医学放射線学会, 2005年02月, 日本医学放射線学会学術集会抄録集, 64回, S380 - S380, 日本語

  • 子宮筋腫に対するMRガイド下集束超音波治療の有用性
    岡田 篤哉, 丸川 太朗, 礒橋 佳也子, 三上 恒治, 村上 卓道, 中村 仁信, Keserci Bilgin
    (公社)日本医学放射線学会, 2005年02月, 日本医学放射線学会学術集会抄録集, 64回, S381 - S381, 日本語

  • 5-FU, CDDP, Adriamucin (FAP)による肝動注化学療法が著効した進行肝細胞癌の2例
    加藤 仁, 村上 卓道
    2005年, 癌と化学療法, 32, 1842 - 1845

  • GDAコイル法におけるマイクロネスター・コイルの有用性
    大須賀 慶悟, 村上 卓道
    留置法として側孔付カテーテルを胃十二指腸動脈(GDA)に留置するGDAコイル法におけるマイクロネスター・コイル(MNC)の有用性について留置工夫も含めて検討した.切除不能肝胆道系悪性腫瘍に対してMNCを用いてGDAコイル法を施行した25例を対象とした.プッシュ法で52個,フラッシュ法で5個,合計57個のMNCをGDAに留置した.全コイルで留置は成功した.14例計17個で側枝アンカー法による留置を行い,膵・十二指腸枝の効率的な側枝塞栓が得られた.MNC留置直後の造影では,いずれもほぼ即時的な血管閉塞を認めた.MNCの位置は血管内で安定し,近位側への逸脱や末梢への移動・迷入は認めなかった.1週間後のポート造影では,全例でGDAの再開通を認めなかった
    (一社)日本インターベンショナルラジオロジー学会, 2005年, IVR会誌, 20(4) (4), 406 - 410, 日本語

  • 血管塞栓用マイクロネスター・コイルの使用経験
    大須賀 慶悟, 村上 卓道
    マイクロネスター・コイル(MNC)は,主に肺動静脈奇形(AVM)や精索静脈瘤で使われているが,動脈での用途も広い.そこで,MNCを動脈で臨床試用した.症例1(65歳女).右腎AVMに対してMNCを留置した.塞栓直後の腎動脈造影で,AVMの描出は完全に消失し,健常部はほぼ温存された.1年後の造影CTでは静脈瘤の血栓化と縮小を認めており完治と考えられた.症例2(58歳男).門脈浸潤を伴う肝細胞癌に対して,GDAコイル法により動注用カテーテルを留置した.総肝動脈造影では,胃十二指腸動脈(GDA)は比較的太くてまっすぐな走行を示した.MNCでGDAの塞栓を行った.塞栓直後の血管造影にてGDAの閉塞を認めた.1週間後のポート造影でもGDAの再開通は認めなかった
    (一社)日本インターベンショナルラジオロジー学会, 2005年, IVR会誌, 20(3) (3), 285 - 288, 日本語

  • [Hepatic arterial infusion chemotherapy (HAIC)--hepatocellular carcinoma].
    Osuga K, Murakami T, Nakata S, Tomoda K, Nagano H, Monden M, Nakamura H
    13, 2004年12月, Gan to kagaku ryoho. Cancer & chemotherapy, 31, 2114 - 2117
    [査読有り]

  • Original report. Hepatic nodular lesions associated with abnormal development of the portal vein.
    T Kim, T Murakami, E Sugihara, M Hori, K Wakasa, H Nakamura
    OBJECTIVE. We reviewed the medical records including pathologic descriptions, CT images, MR images, and digital subtraction angiograms of three patients with hepatic lesions that were associated with abnormal development of the portal vein-patent ductus venosus or congenital absence of the portal vein-to clarify the imaging characteristics of these abnormalities. CONCLUSION. Two-phase helical CT and MRI, including MR angiography and dynamic studies, are useful for the diagnosis of patent ductus venosus and congenital absence of the portal vein. MRI may more effectively reveal hepatic lesions than two-phase helical CT under such abnormal conditions in which the liver has only the arterial but not the portal blood supply.
    AMER ROENTGEN RAY SOC, 2004年11月, AMERICAN JOURNAL OF ROENTGENOLOGY, 183(5) (5), 1333 - 1338, 英語
    研究論文（学術雑誌）

  • R Iannaccone, A Laghi, C Catalano, F Mangiapane, A Lamazza, A Schillaci, G Sinibaldi, T Murakami, P Sammartino, M Hori, F Piacentini, Nofroni, I, Stipa, V, R Passariello
    Aims: We prospectively compared the performance of low-dose multidetector computed tomographic colonography (CTC) without cathartic preparation with that of colonoscopy for the detection of colorectal polyps. Methods: A total of 203 patients underwent low-dose CTC without cathartic preparation followed by colonoscopy. Before CTC, fecal tagging was achieved by adding diatrizoate meglumine and diatrizoate sodium to regular meals. No subtraction of tagged feces was performed. Colonoscopy was performed 3-7 days after CTC. Three readers interpreted the CTC examinations separately and independently using a primary 2-dimensional approach using multiplanar reconstructions and 3-dimensional images for further characterization. Colonoscopy with segmental unblinding was used as reference standard. The sensitivity of CTC was calculated both on a per-polyp and a per-patient basis. For the latter, specificity, positive predictive values, and negative predictive values were also calculated. Results: CTC had an average sensitivity of 95.5% (95% confidence interval [CI], 92.1%99%) for the identification of colorectal polyps greater than or equal to8 mm. With regard to per-patient analysis, CTC yielded an average sensitivity of 89.9% (95% CI, 86%-93.7%), an average specificity of 92.2% (95% CI, 89.5%94.9%), an average positive predictive value of 88% (95% CI, 83.3%-91.5%), and an average negative predictive value of 93.5% (95% CI, 90.9%-96%). Interobserver agreement was high on a per-polyp basis (K statistic range, .61-.74) and high to excellent on a per-patient basis (K statistic range, .79-.91). Conclusions: Low-dose multidetector CTC without cathartic preparation compares favorably with colonoscopy for the detection of colorectal polyps.
    W B SAUNDERS CO, 2004年11月, GASTROENTEROLOGY, 127(5) (5), 1300 - 1311, 英語
    研究論文（学術雑誌）

  • T Kim, T Murakami, E Sugihara, M Hori, K Wakasa, H Nakamura
    OBJECTIVE. We reviewed the medical records including pathologic descriptions, CT images, MR images, and digital subtraction angiograms of three patients with hepatic lesions that were associated with abnormal development of the portal vein-patent ductus venosus or congenital absence of the portal vein-to clarify the imaging characteristics of these abnormalities. CONCLUSION. Two-phase helical CT and MRI, including MR angiography and dynamic studies, are useful for the diagnosis of patent ductus venosus and congenital absence of the portal vein. MRI may more effectively reveal hepatic lesions than two-phase helical CT under such abnormal conditions in which the liver has only the arterial but not the portal blood supply.
    AMER ROENTGEN RAY SOC, 2004年11月, AMERICAN JOURNAL OF ROENTGENOLOGY, 183(5) (5), 1333 - 1338, 英語
    [査読有り]
    研究論文（学術雑誌）

  • R Iannaccone, A Laghi, C Catalano, F Mangiapane, A Lamazza, A Schillaci, G Sinibaldi, T Murakami, P Sammartino, M Hori, F Piacentini, Nofroni, I, Stipa, V, R Passariello
    Aims: We prospectively compared the performance of low-dose multidetector computed tomographic colonography (CTC) without cathartic preparation with that of colonoscopy for the detection of colorectal polyps. Methods: A total of 203 patients underwent low-dose CTC without cathartic preparation followed by colonoscopy. Before CTC, fecal tagging was achieved by adding diatrizoate meglumine and diatrizoate sodium to regular meals. No subtraction of tagged feces was performed. Colonoscopy was performed 3-7 days after CTC. Three readers interpreted the CTC examinations separately and independently using a primary 2-dimensional approach using multiplanar reconstructions and 3-dimensional images for further characterization. Colonoscopy with segmental unblinding was used as reference standard. The sensitivity of CTC was calculated both on a per-polyp and a per-patient basis. For the latter, specificity, positive predictive values, and negative predictive values were also calculated. Results: CTC had an average sensitivity of 95.5% (95% confidence interval [CI], 92.1%99%) for the identification of colorectal polyps greater than or equal to8 mm. With regard to per-patient analysis, CTC yielded an average sensitivity of 89.9% (95% CI, 86%-93.7%), an average specificity of 92.2% (95% CI, 89.5%94.9%), an average positive predictive value of 88% (95% CI, 83.3%-91.5%), and an average negative predictive value of 93.5% (95% CI, 90.9%-96%). Interobserver agreement was high on a per-polyp basis (K statistic range, .61-.74) and high to excellent on a per-patient basis (K statistic range, .79-.91). Conclusions: Low-dose multidetector CTC without cathartic preparation compares favorably with colonoscopy for the detection of colorectal polyps.
    W B SAUNDERS CO, 2004年11月, GASTROENTEROLOGY, 127(5) (5), 1300 - 1311, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Embolic effects of superabsorbent polymer microspheres in rabbit renal model: Comparison with tris-acryl gelatin microspheres and polyvinyl alcohol
    Azzam Anwar Khankan, Keigo Osuga, Shinichi Hori, Eiichi Morii, Takamichi Murakami, Hironobu Nakamura
    Purpose: We have developed a spherical embolic agent, superabsorbent polymer microspheres (SAP-MS). The aim of this study was to examine the embolic effects of SAP-MS in comparison with polyvinyl alcohol (PVA) particles and tris-acryl gelatin microsphere (Embosphere Microsphere EM) in a rabbit renal model. Materials and Methods: The right kidneys of nine rabbits were embolized with the given agents: PVA (180-300 μm) (n=3), EM (100-300 μm) (n=3), and SAP-MS (106-150 μm) (n=3). The embolized kidneys were evaluated by angiography and histology after one week. Results: Renal artery occlusion and prominent coagulative necrosis were confirmed regardless of agent. PVA aggregated in the proximal vessels with tiny fragments migrating into glomeruli. Both EM and SAP-MS traveled distally up to the interlobular artery level, and a single particle achieved cross-sectional vessel occlusion. SAP-MS was markedly swollen, deformed, and conformed to the vessel lumen compared with the constantly spherical EM. Mild perivascular reaction was seen with both microspheres. Conclusion: SAP-MS resulted in targeted end-organ infarction in the rabbit renal model and showed different mechanical properties from other agents.
    6, 2004年11月, Radiation Medicine - Medical Imaging and Radiation Oncology, 22(6) (6), 384 - 390, 英語
    [査読有り]
    研究論文（学術雑誌）

  • H Onishi, M Matsushita, T Murakami, T Tono, S Okamoto, Y Aoki, R Iannaccone, M Hori, T Kim, K Osuga, K Tomoda, R Passariello, H Nakamura
    Rationale and Objectives. The purpose of this study was to evaluate the utility of magnetic resonance (MR) imaging for indicating the extent of true tissue necrosis of the liver after radiofrequency (RF) ablation in comparison with histopathologic findings in dog models and an autopsy case. Materials and Methods. RF ablation of the liver parenchyma was performed on three dogs under general anesthesia. MR appearances of the RF-ablated regions on T1-weighted fast-low angle shot (FLASH; repetition time/echo time [TR/TE]/flip angle: 120/3.8/70), T2-weighted turbo spin echo (3000/80/echo train = 25) and contrast-enhanced T1-weighted images were compared with histopathologic findings. An autopsy case with hepatocellular carcinoma was also enrolled in this study. Results. All ablated regions showed three zones on T1-weighted FLASH images: a central zone with low intensity, a broad hyperintense middle zone, and a surrounding hypointense band. The central and middle zones corresponded to the degrees of coagulation necrosis observed during histopathologic examination, whereas no viable cells were seen in these zones during the microscopic examination using nicotinamide adenine dinucleotide diaphorase stain. The surrounding hypointense band corresponded to sinusoidal congestion in the acute phase and to fibrotic change in the subacute phase. Conclusion. MR imaging using the FLASH sequence can accurately determine the extent of the necrotic area after RF ablation.
    ASSOC UNIV RADIOLOGISTS, 2004年10月, ACADEMIC RADIOLOGY, 11(10) (10), 1180 - 1189, 英語
    研究論文（学術雑誌）

  • H Onishi, M Matsushita, T Murakami, T Tono, S Okamoto, Y Aoki, R Iannaccone, M Hori, T Kim, K Osuga, K Tomoda, R Passariello, H Nakamura
    Rationale and Objectives. The purpose of this study was to evaluate the utility of magnetic resonance (MR) imaging for indicating the extent of true tissue necrosis of the liver after radiofrequency (RF) ablation in comparison with histopathologic findings in dog models and an autopsy case. Materials and Methods. RF ablation of the liver parenchyma was performed on three dogs under general anesthesia. MR appearances of the RF-ablated regions on T1-weighted fast-low angle shot (FLASH; repetition time/echo time [TR/TE]/flip angle: 120/3.8/70), T2-weighted turbo spin echo (3000/80/echo train = 25) and contrast-enhanced T1-weighted images were compared with histopathologic findings. An autopsy case with hepatocellular carcinoma was also enrolled in this study. Results. All ablated regions showed three zones on T1-weighted FLASH images: a central zone with low intensity, a broad hyperintense middle zone, and a surrounding hypointense band. The central and middle zones corresponded to the degrees of coagulation necrosis observed during histopathologic examination, whereas no viable cells were seen in these zones during the microscopic examination using nicotinamide adenine dinucleotide diaphorase stain. The surrounding hypointense band corresponded to sinusoidal congestion in the acute phase and to fibrotic change in the subacute phase. Conclusion. MR imaging using the FLASH sequence can accurately determine the extent of the necrotic area after RF ablation.
    ASSOC UNIV RADIOLOGISTS, 2004年10月, ACADEMIC RADIOLOGY, 11(10) (10), 1180 - 1189, 英語
    [査読有り]
    研究論文（学術雑誌）

  • T Murakami, M Hori, T Kim, K Hashimoto, K Dono, S Hayashi, E Sugihara, H Nagano, S Sase, M Sakon, M Monden, H Nakamura
    Objective: The purpose of this study was to separately measure the arterial and portal venous tissue blood flow (TBF) of hepatocellular carcinoma (HCC) with a noninvasive method using xenon inhalation CT (xenon-CT) and to differentiate between well-differentiated HCCs and moderately and poorly differentiated HCCs. Materials and Methods: Total, arterial and portal venous TBFs of 38 surgically proven HCC nodules from 38 patients were measured by means of xenon-CT. Serial abdominal CT scans were obtained before and after inhalation of nonradioactive xenon gas. TBF was computed using the Fick principle, after which the correlation between TBF and pathologic features of the tumors was determined. Results: Total, arterial, and portal venous TBFs of HCC were 125.7 +/- 59.9 mL/min/100g, 102.5 +/- 37.3, and 22.2 +/- 11.4, respectively, and the corresponding findings for hepatic parenchyma were 67.3 +/- 13.1, 25.2 +/- 9.6, and 42.4 +/- 11.0. Total and arterial TBFs of HCC were significantly higher than those of the hepatic parenchyma (P < 0.01), whereas portal venous TBF of HCC was significantly lower than that of hepatic parenchyma (P < 0.01). Arterial TBF of moderately or poorly differentiated HCC (120.4 +/- 38.2) was significantly higher than that of well-differentiated HCC (60.4 +/- 43.5) (P < 0.01). Conclusions: Arterial and portal venous TBFs of HCC could be measured separately, noninvasively, and safely with xenon-CT. Correlation between TBF and pathologic features of tumors indicate that xenon-CT can be used to differentiate between well-differentiated HCCs and moderately and poorly differentiated HCCs.
    LIPPINCOTT WILLIAMS & WILKINS, 2004年04月, INVESTIGATIVE RADIOLOGY, 39(4) (4), 210 - 215, 英語
    研究論文（学術雑誌）

  • S Goshima, M Kanematsu, M Matsuo, T Murakami, M Hori, M Takamura, H Kondo, N Kako, N Moriyama, H Nakamura, H Hoshi
    The purpose of our study was to assess whether respiratory-triggered multishot fast spin echo (MS-FSE) and breath-hold half-Fourier single-shot fast spin echo (SS-FSE) images, in addition to breath-hold T-2*-weighted gradient recalled echo (GRE) images, increase observer performance in the detection of malignant hepatic tumors with ferumoxide-enhanced magnetic resonance (MR) imaging. Ferumoxide-enhanced MR images obtained from 48 patients with 83 malignant hepatic tumors were retrospectively reviewed by three independent off-site readers. In the first image review, GRE images alone were reviewed. Then, MS-FSE images were added for the first combination review. Finally, SS-FSE images were added for the second combination review. Observer performances were tested by McNemar's test and receiver-operating-characteristic analysis for the clustered data. Sensitivity for hepatocellular carcinomas, metastases, and malignant hepatic tumors overall was significantly (p < 0.05) higher with GRE and MS-FSE combined and GRE, MS-FSE and SS-FSE combined than with GRE alone. For metastases, the Az value was significantly (p < 0.05) higher with GRE and MS-FSE combined, and GRE, MS-FSE and SS-FSE combined than with GRE alone. We confirmed the incremental value of ferumoxide-enhanced MR imaging by obtaining MS-FSE and SS-FSE images in addition to GRE images in the detection of malignant hepatic tumors. (C) 2004 Elsevier Inc. All rights reserved.
    ELSEVIER SCIENCE INC, 2004年04月, MAGNETIC RESONANCE IMAGING, 22(3) (3), 379 - 388, 英語
    研究論文（学術雑誌）

  • T Murakami, M Hori, T Kim, K Hashimoto, K Dono, S Hayashi, E Sugihara, H Nagano, S Sase, M Sakon, M Monden, H Nakamura
    Objective: The purpose of this study was to separately measure the arterial and portal venous tissue blood flow (TBF) of hepatocellular carcinoma (HCC) with a noninvasive method using xenon inhalation CT (xenon-CT) and to differentiate between well-differentiated HCCs and moderately and poorly differentiated HCCs. Materials and Methods: Total, arterial and portal venous TBFs of 38 surgically proven HCC nodules from 38 patients were measured by means of xenon-CT. Serial abdominal CT scans were obtained before and after inhalation of nonradioactive xenon gas. TBF was computed using the Fick principle, after which the correlation between TBF and pathologic features of the tumors was determined. Results: Total, arterial, and portal venous TBFs of HCC were 125.7 +/- 59.9 mL/min/100g, 102.5 +/- 37.3, and 22.2 +/- 11.4, respectively, and the corresponding findings for hepatic parenchyma were 67.3 +/- 13.1, 25.2 +/- 9.6, and 42.4 +/- 11.0. Total and arterial TBFs of HCC were significantly higher than those of the hepatic parenchyma (P < 0.01), whereas portal venous TBF of HCC was significantly lower than that of hepatic parenchyma (P < 0.01). Arterial TBF of moderately or poorly differentiated HCC (120.4 +/- 38.2) was significantly higher than that of well-differentiated HCC (60.4 +/- 43.5) (P < 0.01). Conclusions: Arterial and portal venous TBFs of HCC could be measured separately, noninvasively, and safely with xenon-CT. Correlation between TBF and pathologic features of tumors indicate that xenon-CT can be used to differentiate between well-differentiated HCCs and moderately and poorly differentiated HCCs.
    LIPPINCOTT WILLIAMS & WILKINS, 2004年04月, INVESTIGATIVE RADIOLOGY, 39(4) (4), 210 - 215, 英語
    [査読有り]
    研究論文（学術雑誌）

  • S Goshima, M Kanematsu, M Matsuo, T Murakami, M Hori, M Takamura, H Kondo, N Kako, N Moriyama, H Nakamura, H Hoshi
    The purpose of our study was to assess whether respiratory-triggered multishot fast spin echo (MS-FSE) and breath-hold half-Fourier single-shot fast spin echo (SS-FSE) images, in addition to breath-hold T-2*-weighted gradient recalled echo (GRE) images, increase observer performance in the detection of malignant hepatic tumors with ferumoxide-enhanced magnetic resonance (MR) imaging. Ferumoxide-enhanced MR images obtained from 48 patients with 83 malignant hepatic tumors were retrospectively reviewed by three independent off-site readers. In the first image review, GRE images alone were reviewed. Then, MS-FSE images were added for the first combination review. Finally, SS-FSE images were added for the second combination review. Observer performances were tested by McNemar's test and receiver-operating-characteristic analysis for the clustered data. Sensitivity for hepatocellular carcinomas, metastases, and malignant hepatic tumors overall was significantly (p < 0.05) higher with GRE and MS-FSE combined and GRE, MS-FSE and SS-FSE combined than with GRE alone. For metastases, the Az value was significantly (p < 0.05) higher with GRE and MS-FSE combined, and GRE, MS-FSE and SS-FSE combined than with GRE alone. We confirmed the incremental value of ferumoxide-enhanced MR imaging by obtaining MS-FSE and SS-FSE images in addition to GRE images in the detection of malignant hepatic tumors. (C) 2004 Elsevier Inc. All rights reserved.
    ELSEVIER SCIENCE INC, 2004年04月, MAGNETIC RESONANCE IMAGING, 22(3) (3), 379 - 388, 英語
    [査読有り]
    研究論文（学術雑誌）

  • S Kobayashi, M Hori, K Dono, H Nagano, K Umeshita, S Nakamori, M Sakon, K Osuga, K Umetani, T Murakami, H Nakamura, M Monden
    Background/Aims: The aim of this study was to visualize hepatic microvessels (less than 100 mum in diameter) in vivo, which could not be visualized by conventional X-ray angiography, by using synchrotron radiation (ultra-bright and monochromatic X-ray). Methods: Five female Balb/c nu/nu mice were used. To investigate the hepatic microvessels under nearly physiologic conditions, we performed in vivo aortography under anesthesia with 370 mgI/ml nonionic iodine contrast medium using monochromatic 17-keV X-rays generated by a synchrotron. Images were captured with a pixel matrix size of 1024 x 1024 at a rate of 30 pictures/s. The field of view was 7 mm x 7 mm and thus the pixel size was approximately 7 mum. Captured images were evaluated both qualitatively and quantitatively. Results: Small hepatic arterial and portal venous branches of the liver were visualized separately during one sequential aortogram. The minimum diameter of the vessels observed was approximately 20 mum, and the vessels which ran parallel to the hepatic artery were observed and it seemed to be intrahepatic peribiliary arterial plexus. Conclusions: Our new experimental model would be useful for visualization of changes in the hepatic microcirculation under nearly physiologic conditions. (C) 2003 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
    ELSEVIER SCIENCE BV, 2004年03月, JOURNAL OF HEPATOLOGY, 40(3) (3), 405 - 408, 英語
    研究論文（学術雑誌）

  • S Kobayashi, M Hori, K Dono, H Nagano, K Umeshita, S Nakamori, M Sakon, K Osuga, K Umetani, T Murakami, H Nakamura, M Monden
    Background/Aims: The aim of this study was to visualize hepatic microvessels (less than 100 mum in diameter) in vivo, which could not be visualized by conventional X-ray angiography, by using synchrotron radiation (ultra-bright and monochromatic X-ray). Methods: Five female Balb/c nu/nu mice were used. To investigate the hepatic microvessels under nearly physiologic conditions, we performed in vivo aortography under anesthesia with 370 mgI/ml nonionic iodine contrast medium using monochromatic 17-keV X-rays generated by a synchrotron. Images were captured with a pixel matrix size of 1024 x 1024 at a rate of 30 pictures/s. The field of view was 7 mm x 7 mm and thus the pixel size was approximately 7 mum. Captured images were evaluated both qualitatively and quantitatively. Results: Small hepatic arterial and portal venous branches of the liver were visualized separately during one sequential aortogram. The minimum diameter of the vessels observed was approximately 20 mum, and the vessels which ran parallel to the hepatic artery were observed and it seemed to be intrahepatic peribiliary arterial plexus. Conclusions: Our new experimental model would be useful for visualization of changes in the hepatic microcirculation under nearly physiologic conditions. (C) 2003 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
    ELSEVIER SCIENCE BV, 2004年03月, JOURNAL OF HEPATOLOGY, 40(3) (3), 405 - 408, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Efficacy of multi-slice helical CT venography for the diagnosis of deep venous thrombosis: Comparison with venous sonography
    Tonsok Kim, Takamichi Murakami, Masatoshi Hori, Seishi Kumano, Masato Sakon, Hironobu Nakamura
    Objective: The purpose of this study was to assess the efficacy of contrast enhanced multislice helical CT (MSCT) venography for the diagnosis of deep venous thrombosis (DVT) in comparison with venous sonography. Materials and Methods: MSCT was used to obtain contiguous, 5-mm thick axial CT images from the diaphragm to the ankles of 27 patients after intravenous injection of contrast material. These patients were clinically suspected of having DVT. The same patients underwent venous sonography before CT examination. The detectability of DVT with MSCT venography was compared with that with venous sonography. Results: MSCT venography detected DVT in 21 patients, but venous sonography did so in only 17. MSCT venography detected DVT missed by venous sonography in five patients, while venous sonography detected DVT missed by MSCT venography in one patient. Conclusion: MSCT venography can be expected to make a valuable contribution to the diagnosis of DVT and to the prophylaxis of pulmonary embolism.
    2, 2004年03月, Radiation Medicine - Medical Imaging and Radiation Oncology, 22(2) (2), 77 - 81, 英語
    [査読有り]
    研究論文（学術雑誌）

  • S Takahashi, T Murakami, M Takamura, T Kim, M Hori, Y Narumi, H Nakamura
    Purpose: To evaluate the usefulness of half-dose contrast-enhanced magnetic resonance (MR) angiography for depicting the abdominal aorta and its major branches. Materials and Methods: A total of 72 consecutive patients were randomly assigned to one of four groups that underwent MR angiography after receiving different concentrations (original or diluted to 50%) and total amounts (single or half-dose) of gadolinium chelate injected at different rates (1 or 0.5 mL/second). The signal-to-noise ratio (SNR) and contrast-to-noise ratio, (CNR) of the abdominal aorta and of the common and external iliac arteries were calculated, and two blinded readers rated the respective image qualities. Results: The SNR and CNR of the abdominal aorta and the common iliac artery in the 0.5 mL/second groups were statistically significantly lower than those in the 1 mL/second groups. The differences in overall image quality across the four groups were not statistically significant. Conclusion: Half-dose MR angiography using diluted contrast medium injected at a rate of 1 mL/second depicted the abdominal aorta and its branches as clearly as using a full single dose.
    JOHN WILEY & SONS INC, 2004年02月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 19(2) (2), 194 - 201, 英語
    研究論文（学術雑誌）

  • S Takahashi, T Murakami, M Takamura, T Kim, M Hori, Y Narumi, H Nakamura
    Purpose: To evaluate the usefulness of half-dose contrast-enhanced magnetic resonance (MR) angiography for depicting the abdominal aorta and its major branches. Materials and Methods: A total of 72 consecutive patients were randomly assigned to one of four groups that underwent MR angiography after receiving different concentrations (original or diluted to 50%) and total amounts (single or half-dose) of gadolinium chelate injected at different rates (1 or 0.5 mL/second). The signal-to-noise ratio (SNR) and contrast-to-noise ratio, (CNR) of the abdominal aorta and of the common and external iliac arteries were calculated, and two blinded readers rated the respective image qualities. Results: The SNR and CNR of the abdominal aorta and the common iliac artery in the 0.5 mL/second groups were statistically significantly lower than those in the 1 mL/second groups. The differences in overall image quality across the four groups were not statistically significant. Conclusion: Half-dose MR angiography using diluted contrast medium injected at a rate of 1 mL/second depicted the abdominal aorta and its branches as clearly as using a full single dose.
    JOHN WILEY & SONS INC, 2004年02月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 19(2) (2), 194 - 201, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 中村将人, 村上 卓道
    2004年, 肝臓, 45, 320 - 328

  • 井上 隆弘, 村上 卓道
    2004年, 肝臓, 45(9) (9), 499 - 504

  • MRI造影剤Gd-EOB-DTPA/SH L 569Bシリンジ製剤の有用性に関する評価
    村上 卓道, 中村仁信
    2004年, 新薬と臨床, 53, 1162 - 1172

  • Embolic effects of superabsorbent polymer microspheres in rabbit renal model: comparison with tris-acryl gelatin microspheres and polyvinyl alcohol.
    Khankan AA, 村上 卓道
    2004年, Radiat Med, 2, 384 - 390

  • Efficacy of multi-slice helical CT venography for the diagnosis of deep venous thrombosis. Comparison with venous sonography.
    金 東石, 村上 卓道
    2004年, Radiat Med, 22, 77 - 81

  • S Takiguchi, M Sekimoto, Y Fujiwara, T Yasuda, M Yano, M Hod, T Murakami, H Nakamura, M Monden
    Background: Laparoscopic extended lymph node dissection for gastric cancer is difficult to perform because it requires dissection with preservation of vessels. Therefore, an intraoperative navigation system for the angioarchitecture would be helpful. Recent enhanced volume-rendering, computed tomography (CT) can produce clear intra:luminal three-dimensional (3D) images. This advanced radiological technology can provide 3D angiographic images reconstructed in the same view as would be observed from a laparoscope inserted into the abdominal cavity. We report our experience with laparoscopic gastrectomy with radical lymph node dissection using this advanced radiological technology. Methods: 3D CT angiographic images from the celiac axis to the proper hepatic artery were reconstructed in two ways preoperatively. The first was only 3D angiographic images that were reconstructed as the laparoscopic view (LapView 3D CT angiography). The second was LapView 3D CT angiography with images of the body of the pancreas, which was more useful for intraoperative navigation in comprehensing anatomy. Two monitors were placed over the shoulder of the patient during surgery. One monitor, which was controlled by the image mixer, projected the laparoscopic images with picture in picture of 3D CT angiographic images. The surgeon performed the surgery with reference to this monitor during lymph node dissection. Results: 3D angiographic CT clearly showed all vessels of interest in laparoscopic lymph node dissection for gastric cancer in 10 cases. The anatomy of vessels appeared as if looking beyond visible surface. LapView 3D CT angiography was useful for laparoscopic navigation surgery.
    SPRINGER-VERLAG, 2004年01月, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 18(1) (1), 106 - 110, 英語
    研究論文（学術雑誌）

  • T Sasaki, T Hasegawa, T Kimura, A Okada, T Murakami, T Sugiura, K Ohsuga
    Background: For giant gastric varices in association with portal hypertension, endoscopic treatment often is difficult. Although balloon-occluded retrograde transvenous obliteration (B-RTO) has been performed successfully in adult cirrhotic patients, there has been no report in pediatric patients. Methods: A 10-year-old girl with biliary atresia (BA) who had been free of jaundice after hepatic portoenterostomy was detected to have isolated gastric fundal varices by routine endoscopy. They gradually enlarged up to 4 cm in diameter, showing a tense appearance, so prophylactic treatment was conducted. Magnetic resonance angiography showed the blood flow of the varices mainly drained by a large gastrorenal shunt. A balloon catheter was introduced into the gastrorenal shunt via the femoral vein and was inflated to occlude the outflow of the varices. Five percent ethanolamine oleate was injected into the varices, and the outflow occlusion was kept for more than 30 minutes. Extensive thrombosis was achieved by an additional embolotherapy after 17 months. Throughout the course, the patient has been doing well without bleeding or worsening of the liver function tests. Conclusions: B-RTO for isolated gastric fundal varices has been performed safely in a pediatric patient and seems effective in reducing the variceal size and tension. (C) 2004 Elsevier Inc. All rights reserved.
    W B SAUNDERS CO, 2004年01月, JOURNAL OF PEDIATRIC SURGERY, 39(1) (1), 130 - 132, 英語
    研究論文（学術雑誌）

  • Detection of malignant hepatic tumors with ferumoxides-enhanced MRI: Comparison of five gradient-recalled echo sequences with different TEs
    M Matsuo, M Kanematsu, K Itoh, T Murakami, Y Maetani, H Kondo, S Goshima, N Kako, H Hoshi, J Konishi, N Moriyama, H Nakamura
    OBJECTIVE. The purpose of our study was to compare the detectability of malignant hepatic tumors on ferumoxides -enhanced MRI using five gradient-recalled echo sequences at different TEs. MATERIALS AND METHODS. Ferumoxides-enhanced MRIs obtained in 31 patients with 50 malignant hepatic tumors (33 hepatocellular carcinomas, 17 metastases) were reviewed retrospectively by three independent offsite radiologists. T1-weighted gradient-recalled echo images with TEs of 1.4 and 4.2 msec; T2*-weighted gradient-recalled echo images with TEs of 6, 8, and 10 msec; and T2-weighted fast spin-echo images of livers were randomly reviewed on a segment-by-segment basis. Observer performance was tested using the McNemar test and receiver operating characteristic analysis for the clustered data. Lesion-to-liver contrast-to-noise ratio was also assessed. RESULTS. Mean lesion-to-liver contrast-to-noise ratios were negative and lower with gradient-recalled echo at 1.4 msec than with the other sequences. Sensitivity was higher (P < 0.05) with gradient-recalled echo at 6, 8, and 10 msec and fast spin-echo sequences (75-83%) than with gradient-recalled echo sequences at 1.4 and 4.2 msec (46-48%), and was higher (p < 0.05) with gradient-recalled echo sequence at 8 msec (83%) than with gradient-recalled echo at 6 msec and fast spin-echo sequences (75-78%). Specificity was comparably high with all sequences (95-98%). The area under the receiver operating characteristic curve (A,) was greater (p < 0.05) with gradient-recalled echo at 6, 8, and 10 msec and fast spin-echo sequences (A(Z) = 0.91-0.93) than with gradient-recalled echo sequences at 1.4 and 4.2 msec (A(z) = 0.82-0.85). CONCLUSION. In the detection of malignant hepatic tumors, gradient-recalled echo sequences at 8 msec showed the highest sensitivity and had an Az value and lesion-to-liver contrast-to-noise ratio comparable with values from gradient-recalled echo sequences at 6 and 10 msec and fast spin-echo sequences.
    AMER ROENTGEN RAY SOC, 2004年01月, AMERICAN JOURNAL OF ROENTGENOLOGY, 182(1) (1), 235 - 242, 英語
    研究論文（学術雑誌）

  • M Matsuo, M Kanematsu, K Itoh, T Murakami, Y Maetani, H Kondo, S Goshima, N Kako, H Hoshi, J Konishi, N Moriyama, H Nakamura
    OBJECTIVE. The purpose of our study was to compare the detectability of malignant hepatic tumors on ferumoxides -enhanced MRI using five gradient-recalled echo sequences at different TEs. MATERIALS AND METHODS. Ferumoxides-enhanced MRIs obtained in 31 patients with 50 malignant hepatic tumors (33 hepatocellular carcinomas, 17 metastases) were reviewed retrospectively by three independent offsite radiologists. T1-weighted gradient-recalled echo images with TEs of 1.4 and 4.2 msec; T2*-weighted gradient-recalled echo images with TEs of 6, 8, and 10 msec; and T2-weighted fast spin-echo images of livers were randomly reviewed on a segment-by-segment basis. Observer performance was tested using the McNemar test and receiver operating characteristic analysis for the clustered data. Lesion-to-liver contrast-to-noise ratio was also assessed. RESULTS. Mean lesion-to-liver contrast-to-noise ratios were negative and lower with gradient-recalled echo at 1.4 msec than with the other sequences. Sensitivity was higher (P < 0.05) with gradient-recalled echo at 6, 8, and 10 msec and fast spin-echo sequences (75-83%) than with gradient-recalled echo sequences at 1.4 and 4.2 msec (46-48%), and was higher (p < 0.05) with gradient-recalled echo sequence at 8 msec (83%) than with gradient-recalled echo at 6 msec and fast spin-echo sequences (75-78%). Specificity was comparably high with all sequences (95-98%). The area under the receiver operating characteristic curve (A,) was greater (p < 0.05) with gradient-recalled echo at 6, 8, and 10 msec and fast spin-echo sequences (A(Z) = 0.91-0.93) than with gradient-recalled echo sequences at 1.4 and 4.2 msec (A(z) = 0.82-0.85). CONCLUSION. In the detection of malignant hepatic tumors, gradient-recalled echo sequences at 8 msec showed the highest sensitivity and had an Az value and lesion-to-liver contrast-to-noise ratio comparable with values from gradient-recalled echo sequences at 6 and 10 msec and fast spin-echo sequences.
    AMER ROENTGEN RAY SOC, 2004年01月, AMERICAN JOURNAL OF ROENTGENOLOGY, 182(1) (1), 235 - 242, 英語
    [査読有り]
    研究論文（学術雑誌）

  • T Sasaki, T Hasegawa, T Kimura, A Okada, T Murakami, T Sugiura, K Ohsuga
    Background: For giant gastric varices in association with portal hypertension, endoscopic treatment often is difficult. Although balloon-occluded retrograde transvenous obliteration (B-RTO) has been performed successfully in adult cirrhotic patients, there has been no report in pediatric patients. Methods: A 10-year-old girl with biliary atresia (BA) who had been free of jaundice after hepatic portoenterostomy was detected to have isolated gastric fundal varices by routine endoscopy. They gradually enlarged up to 4 cm in diameter, showing a tense appearance, so prophylactic treatment was conducted. Magnetic resonance angiography showed the blood flow of the varices mainly drained by a large gastrorenal shunt. A balloon catheter was introduced into the gastrorenal shunt via the femoral vein and was inflated to occlude the outflow of the varices. Five percent ethanolamine oleate was injected into the varices, and the outflow occlusion was kept for more than 30 minutes. Extensive thrombosis was achieved by an additional embolotherapy after 17 months. Throughout the course, the patient has been doing well without bleeding or worsening of the liver function tests. Conclusions: B-RTO for isolated gastric fundal varices has been performed safely in a pediatric patient and seems effective in reducing the variceal size and tension. (C) 2004 Elsevier Inc. All rights reserved.
    W B SAUNDERS CO, 2004年01月, JOURNAL OF PEDIATRIC SURGERY, 39(1) (1), 130 - 132, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M Hori, T Murakami, T Kim, K Tomoda, H Nakamura
    Computed tomography (CT) and magnetic resonance imaging (MRI) are useful for detection and characterization of liver tumors, and widely used in clinical practice. By using dynamic CT and MRI with extracellular contrast material or MRI with liver-specific contrast material, we can investigate the morphological, hemodynamical and functional nature of focal hepatic lesions. Tumors often show characteristic findings on CT and MRI. Thus, we can correctly establish a diagnosis of liver tumors based on those findings. In this article, we describe the role of CT scan and MRI in the differentiation of liver tumors as well as presenting some typical CT and MR images. Copyright (C) 2004 S. Karger AG, Basel.
    KARGER, 2004年, DIGESTIVE DISEASES, 22(1) (1), 39 - 55, 英語
    [査読有り]

  • T Murakami, M Hori, T Kim, S Kawata, H Abe, H Nakamura
    It is important to diagnose hepatocellular carcinoma (HCC) correctly and in early stage, because viral hepatitis and liver cirrhosis are often complicated by HCC. Non-contrast and enhanced CT and MRI are very useful to visualize and diagnose HCC objectively. Especially, CT and MR imaging with dynamic study is essential to diagnose HCC, because it is usually hypervascular. Dynamic CT and MR study also improve differential diagnosis in the characterization of the tumor. However, to perform useful dynamic study, it is necessary to use a CT unit which can make a helical scan, or a MR system with fast imaging technique available that can obtain more than 15 slices within a single breath hold. Tissue specific contrast medium, such as superparamagnetic iron oxide that is available only on MRI, is also useful for diagnosis of HCC. Copyright (C) 2004 S. Karger AG, Basel.
    KARGER, 2004年, INTERVIROLOGY, 47(3-5) (3-5), 209 - 226, 英語
    [査読有り]
    研究論文（学術雑誌）

  • T. Hashimoto, H. Nakamura, S. Hori, K. Tomoda, T. Mitani, T. Murakami, T. Kozuka, M. Monden, K. Wakasa, M. Sakurai
    Two patients with mixed hepatocellular and cholangiocellular carcinoma underwent partial hepatectomy after magnetic resonance (MR) imaging. Correlation is made with the histopathologic manifestations. In both cases the tumors showed relative low signal intensities on T1-weighted spin-echo (SE) images and high signal intensities on T2-weighted SE images. Dynamic MR imaging showed the enhancement from the periphery of the tumor to the inner area gradually and the enhancement continued into the delayed phase. With both cases fibrosis was marked in the inner area of the tumor compared to the peripheral area. The extent and degree of fibrotic tissue is considered to reflect the enhancement on dynamic MR imaging. © 1994 Springer-Verlag New York Inc.
    Springer-Verlag, 2004年, Abdominal Imaging, 19(5) (5), 430 - 432, 英語
    [査読有り]
    研究論文（学術雑誌）

  • T Murakami, T Kim, M Hori, MP Federle
    RADIOLOGICAL SOC NORTH AMERICA, 2003年12月, RADIOLOGY, 229(3) (3), 931 - 932, 英語

  • J Masumoto, Y Sato, M Hori, T Murakami, T Johkoh, H Nakamura, S Tamura
    A similarity measure for nonrigid volume registration with known joint distribution of a targeted tissue is developed to process tissue slide at the boundaries between the targeted and non-targeted tissues. Pre-segmentation of the targeted tissue is unnecessary. This measure is applied to registering volumes acquired at different time-phases in dynamic CT scans of the liver using contrast materials and can be derived for the case where only the joint distribution of the targeted tissue is known. The similarity measure is formulated as a likelihood by introducing a concept termed 'exclusivity condition' and embedded into a cost function for nonrigid registration to be combined with the smoothness term. In addition, a practical method for estimating the joint distribution of the liver from unregistered clinical CT data is described. We demonstrate experimentally that tissue slide is effectively processed by this proposed measure using simulated dynamic CT data generated from a software phantom and clinical CT data of eight patients. (C) 2003 Elsevier B.V. All rights reserved.
    ELSEVIER SCIENCE BV, 2003年12月, MEDICAL IMAGE ANALYSIS, 7(4) (4), 553 - 564, 英語
    研究論文（学術雑誌）

  • J Masumoto, Y Sato, M Hori, T Murakami, T Johkoh, H Nakamura, S Tamura
    A similarity measure for nonrigid volume registration with known joint distribution of a targeted tissue is developed to process tissue slide at the boundaries between the targeted and non-targeted tissues. Pre-segmentation of the targeted tissue is unnecessary. This measure is applied to registering volumes acquired at different time-phases in dynamic CT scans of the liver using contrast materials and can be derived for the case where only the joint distribution of the targeted tissue is known. The similarity measure is formulated as a likelihood by introducing a concept termed 'exclusivity condition' and embedded into a cost function for nonrigid registration to be combined with the smoothness term. In addition, a practical method for estimating the joint distribution of the liver from unregistered clinical CT data is described. We demonstrate experimentally that tissue slide is effectively processed by this proposed measure using simulated dynamic CT data generated from a software phantom and clinical CT data of eight patients. (C) 2003 Elsevier B.V. All rights reserved.
    ELSEVIER SCIENCE BV, 2003年12月, MEDICAL IMAGE ANALYSIS, 7(4) (4), 553 - 564, 英語
    [査読有り]
    研究論文（学術雑誌）

  • J Masumoto, Y Sato, M Hori, T Murakami, T Johkoh, H Nakamura, S Tamura
    A similarity measure for nonrigid volume registration with known joint distribution of a targeted tissue is developed to process tissue slide at the boundaries between the targeted and non-targeted tissues. Pre-segmentation of the targeted tissue is unnecessary. This measure is applied to registering volumes acquired at different time-phases in dynamic CT scans of the liver using contrast materials and can be derived for the case where only the joint distribution of the targeted tissue is known. The similarity measure is formulated as a likelihood by introducing a concept termed 'exclusivity condition' and embedded into a cost function for nonrigid registration to be combined with the smoothness term. In addition, a practical method for estimating the joint distribution of the liver from unregistered clinical CT data is described. We demonstrate experimentally that tissue slide is effectively processed by this proposed measure using simulated dynamic CT data generated from a software phantom and clinical CT data of eight patients. (C) 2003 Elsevier B.V. All rights reserved.
    ELSEVIER SCIENCE BV, 2003年12月, MEDICAL IMAGE ANALYSIS, 7(4) (4), 553 - 564, 英語
    [査読有り]
    研究論文（学術雑誌）

  • T Murakami, T Kim, M Hori, MP Federle
    RADIOLOGICAL SOC NORTH AMERICA, 2003年12月, RADIOLOGY, 229(3) (3), 931 - 932, 英語
    [査読有り]

  • Dose investigation of superparamagnetic iron oxide (SPIO) SH U 555 A in liver MR imaging
    Hirohashi Shinji, Ichikawa Tomoaki, Tanimoto Akihiro, Isobe Yoshinori, Hachiya Junichi, Saito Kazuhiro, Isoda Hiroyoshi, Nishimura Hiroshi, Kuwatsuru Ryohei, Gokan Takehiko, Murakami Takamichi, Nakano Shigeyuki, Seriu Taku
    SH U 555 A, a new superparamagnetic iron oxide(SPIO)contrast agent for liver MR imaging, was investigated in terms of safety and efficacy. Eighty-four patients with suspected malignant liver tumor were randomly allocated to two groups: the L dose group (8 μmol Fe/kg) and H dose group (12 μmol Fe/kg). Efficacy was qualitatively evaluated through blinded reading of the MR images. Assessment of the images revealed no consistent differences between the L and H dose groups. During the 3- to 4-day observation period, a total of 16 adverse events were observed in 11 patients: 8 patients in the L dose group and 3 patients in the H dose group. Nasal bleeding occurred in 2 of these cases in the H dose group 2 and 4 days, respectively, after injection. Although patients in the H dose group showed a significantly larger transient decrease in Coagulation Factor XI at 4-6 hr post-injection (p. i.) than patients in the L dose group, analysis of covariance revealed an estimated 6.5% difference. There was no prolongation of APTT or change in Factor XI at 72-96 hr p. i. Because there were no clinically significant differences between the L and H doses, both were considered to be safe and effective.
    9, 2003年11月, Nippon Acta Radiologica, 63(9) (9), 539 - 550, 日本語
    [査読有り]
    研究論文（学術雑誌）

  • Using superparamagnetic iron oxide-enhanced MRI to differentiate metastatic hepatic tumors and nonsolid benign lesions
    S Kumano, T Murakami, T Kim, M Hori, A Okada, T Sugiura, Y Noguchi, S Kawata, K Tomoda, H Nakamura
    OBJECTIVE. We evaluated the ability of superparamagnetic iron oxide (SPIO)-enhanced MRI to differentiate solid metastatic tumors and nonsolid benign lesions by clarifying the characteristic signal-intensity pattern of each lesion on SPIO-enhanced T2-weighted and heavily T1-weighted gradient-echo images. MATERIALS AND METHODS. SPIO-enhanced MRI was performed using a 1.5-T system in 33 consecutive patients without cirrhosis who had 81 focal hepatic lesions (42 cysts, 13 hemangiomas, 26 metastatic tumors). The relative signal intensity of lesions on SPIO-enhanced heavily T1- and T2-weighted gradient-echo images was classified into one of the following three categories: high intensity, isointensity, or low intensity relative to the surrounding liver parenchyma. The diagnostic accuracy for differentiating solid metastatic tumors from nonsolid benign lesions (cysts or hemangiomas) was determined. RESULTS. A combination of the relative signal intensity of the lesion on T2- and heavily T1-weighted gradient-echo images could be classified into the following five categories: high intensity and high intensity (category 1), high intensity and isointensity (category 2), high intensity and low intensity (category 3), isointensity and isointensity (category 4), and isointensity and low intensity (category 5). According to these categories, category 1 contained two hemangiomas, category 2 had 11 hemangiomas, category 3 had 25 metastatic tumors and two cysts, category 4 had three cysts, and category 5 had 37 cysts and one metastatic tumor. When a tumor with a relative signal intensity of categories I or 2 was considered to be a hemangioma (category 3 metastatic tumors and categories 4 and 5 cysts), diagnostic accuracy for characterizing such hepatic lesions was 96% (78/81). CONCLUSION. When evaluating metastatic liver tumors on SPIO-enhanced MRI, we recommend that heavily T1- and T2-weighted gradient-echo images be obtained with our parameters to exclude hemangiomas or cysts.
    AMER ROENTGEN RAY SOC, 2003年11月, AMERICAN JOURNAL OF ROENTGENOLOGY, 181(5) (5), 1335 - 1339, 英語
    研究論文（学術雑誌）

  • S Kumano, T Murakami, T Kim, M Hori, A Okada, T Sugiura, Y Noguchi, S Kawata, K Tomoda, H Nakamura
    OBJECTIVE. We evaluated the ability of superparamagnetic iron oxide (SPIO)-enhanced MRI to differentiate solid metastatic tumors and nonsolid benign lesions by clarifying the characteristic signal-intensity pattern of each lesion on SPIO-enhanced T2-weighted and heavily T1-weighted gradient-echo images. MATERIALS AND METHODS. SPIO-enhanced MRI was performed using a 1.5-T system in 33 consecutive patients without cirrhosis who had 81 focal hepatic lesions (42 cysts, 13 hemangiomas, 26 metastatic tumors). The relative signal intensity of lesions on SPIO-enhanced heavily T1- and T2-weighted gradient-echo images was classified into one of the following three categories: high intensity, isointensity, or low intensity relative to the surrounding liver parenchyma. The diagnostic accuracy for differentiating solid metastatic tumors from nonsolid benign lesions (cysts or hemangiomas) was determined. RESULTS. A combination of the relative signal intensity of the lesion on T2- and heavily T1-weighted gradient-echo images could be classified into the following five categories: high intensity and high intensity (category 1), high intensity and isointensity (category 2), high intensity and low intensity (category 3), isointensity and isointensity (category 4), and isointensity and low intensity (category 5). According to these categories, category 1 contained two hemangiomas, category 2 had 11 hemangiomas, category 3 had 25 metastatic tumors and two cysts, category 4 had three cysts, and category 5 had 37 cysts and one metastatic tumor. When a tumor with a relative signal intensity of categories I or 2 was considered to be a hemangioma (category 3 metastatic tumors and categories 4 and 5 cysts), diagnostic accuracy for characterizing such hepatic lesions was 96% (78/81). CONCLUSION. When evaluating metastatic liver tumors on SPIO-enhanced MRI, we recommend that heavily T1- and T2-weighted gradient-echo images be obtained with our parameters to exclude hemangiomas or cysts.
    AMER ROENTGEN RAY SOC, 2003年11月, AMERICAN JOURNAL OF ROENTGENOLOGY, 181(5) (5), 1335 - 1339, 英語
    [査読有り]
    研究論文（学術雑誌）

  • [A case of successful treatment of advanced hepatocellular carcinoma with tumor thrombi in the major portal branches and inferior vena cava with combined intraarterial 5-fluorouracil, adriamycin and cisplatin therapy].
    Ota H, Nagano H, Sakon M, Yamamoto T, Nakamura M, Marubashi S, Miyamoto A, Dono K, Umeshita K, Nakamori S, Murakami T, Nakamura H, Monden M
    11, 2003年10月, Gan to kagaku ryoho. Cancer & chemotherapy, 30, 1673 - 1677
    [査読有り]

  • Abdominal applications of multislice CT
    Kim Tonsok, Murakami Takamichi, Nakamura Hironobu
    Multislice helical CT has made it possible to obtain thinner images with wider coverage at a higher speed in comparison with single-slice helical CT and has improved temporal and spatial resolution. The higher speed available with multislice CT has enabled double arterial phase imaging of the liver and both arterial and pancreatic phase imaging of the pancreas in a single breath-hold. Just as multislice CT has improved the diagnoses of hepatic tumors and pancreatic tumors, it has also improved the quality of three-dimensional imaging, such as multiplanar reformation and CT angiography, by its thinner images. CT angiography is replacing conventional angiography for presurgical evaluation.
    8, 2003年08月, Nippon Acta Radiologica, 63(8) (8), 369 - 377, 日本語
    [査読有り]
    研究論文（学術雑誌）

  • J Shimizu, H Oka, K Dono, M Sakon, M Takamura, T Murakami, S Hayashi, H Nagano, S Nakamori, K Umeshita, S Sase, M Gotoh, K Wakasa, H Nakamura, M Monden
    The aim of this study was to quantitatively measure tissue blood flow (TBF) in hepatocellular carcinoma (HCC) by a noninvasive method using xenon (Xe) inhalation/CT scans and to correlate the measured TBF with histological features. TBF was measured in HCC with xenon-enhanced CT (xenon/CT) in 20 patients. In 15 patients with HCC diagnosed as hypervascular tumors by conventional CT, TBF of the tumors was significantly higher than that of noncancerous liver tissue (151.1 +/- 20 vs 42.6 +/- 20 ml/min/100 g). Histologically, these tumors were diagnosed as moderately-to-poorly differentiated HCC. In contrast, in five patients with hypovascular HCC, TBF of HCC was almost comparable to that of the noncancerous regions (45.3 +/- 6 vs 48.3 +/- 6 ml/min/100 g). All these tumors were well-differentiated HCC. In conclusions, the measured values of TBF correlate with the clinicopathologic features of liver tumors and nontumorous liver tissue in patients with HCC.
    KLUWER ACADEMIC/PLENUM PUBL, 2003年08月, DIGESTIVE DISEASES AND SCIENCES, 48(8) (8), 1510 - 1516, 英語
    研究論文（学術雑誌）

  • T Murakami, T Kim, S Kawata, M Kanematsu, MP Federle, M Hori, A Okada, S Kumano, E Sugihara, K Tomoda, H Nakamura
    Purpose: We evaluated the optimal timing of arterial phase imaging for detection of hypervascular hepatocellular carcinoma by using triple arterial phase imaging with multi detector-row helical computed tomography. Materials and Methods: Forty-nine patients with 90 hypervascular hepatocellular carcinomas (3 to 50 mm in diameter; mean, 18.7 mm) under-went triple arterial phase imaging of the whole liver using a multidetector-row helical computed tomography. At 20 seconds, 30 seconds, and 40 seconds after intravenous administration of 100 mL of 300 mgI/mL of nonionic contrast medium at a rate of 4 mL/s, early, middle, and late arterial phase images were obtained serially during a single breath-hold with an interscan delay of 5 seconds. Detector-row configurations of 4 mm x 4, scan pitch of 5.5, and scan time of 5 seconds for each phase were used. Forty prospective reconstruction images of 5-mm thickness for each phase were obtained. The images from each phase were interpreted separately for detection of hypervascular hepatocellular carcinoma by 3 observers independently who were unaware of tumor burden in the liver. Sensitivity, positive predictive value, and area under the receiver operating characteristic curve values for each arterial phase were calculated and compared statistically. Results: The mean sensitivity and positive predictive values for hypervascular hepatocellular carcinoma diagnosis of blind readers were 37% and 87% for the early arterial phase, 73% and 85% for the middle arterial phase, and 49% and 81% for the late arterial phase, respectively. The middle arterial phase imaging showed significantly superior sensitivity compared with the early and late arterial phase for detecting hepatocellular carcinoma (P < 0.05). Mean area under the receiver operating characteristic curve value of the middle arterial phase imaging (0.84) was significantly higher that that of the early (0.56) or late arterial phase (0.62; P < 0.05). Conclusion: If a single arterial phase is used for diagnosis of hypervascular hepatocellular carcinoma, the middle phase (delay time of 30 seconds) is optimal.
    LIPPINCOTT WILLIAMS & WILKINS, 2003年08月, INVESTIGATIVE RADIOLOGY, 38(8) (8), 497 - 503, 英語
    研究論文（学術雑誌）

  • Jun Masumoto, Masatoshi Hori, Yoshinobu Sato, Takamichi Murakami, Takeshi Johkoh, Hironobu Nakamura, Shinichi Tamura
    With practical applications of multislice CT, high-speed imaging has drastically become possible in recent years as compared with the past and imaging the liver twice during the time a patient holds his breath once has become possible in liver CT imaging using contrast media. Thus, three-dimensional images of two time phases differing in the circulatory state of a contrast medium are obtainable without positional discrepancies. The authors propose an automated liver area extracting (segmenting) method using three-dimensional CT images of two time phases of a contrast medium for extracting the shape of the liver. This method first constructs a two-dimensional characteristic (feature) space having the CT values of time phases on each axis from the three-dimensional images of a two time phase portion imaged immediately after and 10-plus seconds after the infusion of a contrast medium. The method extracts areas showing changes in the contrast medium corresponding to the liver in this space and generates images with the liver region emphasized using these. The method then determines the liver region by performing opening and closing procedures on the liver area-emphasized images generated. Finally, it determines the liver region by a three-dimensional component connecting procedure using geometric shape characteristics of the blood vessels, tumors, and so on. The efficacy of using images of two time phases simultaneously has been verified by applying the proposed method to nine cases. © 2003 Wiley Periodicals, Inc.
    2003年08月, Systems and Computers in Japan, 34(9) (9), 71 - 82, 英語
    [査読有り]
    研究論文（学術雑誌）

  • T Murakami, T Kim, S Kawata, M Kanematsu, MP Federle, M Hori, A Okada, S Kumano, E Sugihara, K Tomoda, H Nakamura
    Purpose: We evaluated the optimal timing of arterial phase imaging for detection of hypervascular hepatocellular carcinoma by using triple arterial phase imaging with multi detector-row helical computed tomography. Materials and Methods: Forty-nine patients with 90 hypervascular hepatocellular carcinomas (3 to 50 mm in diameter; mean, 18.7 mm) under-went triple arterial phase imaging of the whole liver using a multidetector-row helical computed tomography. At 20 seconds, 30 seconds, and 40 seconds after intravenous administration of 100 mL of 300 mgI/mL of nonionic contrast medium at a rate of 4 mL/s, early, middle, and late arterial phase images were obtained serially during a single breath-hold with an interscan delay of 5 seconds. Detector-row configurations of 4 mm x 4, scan pitch of 5.5, and scan time of 5 seconds for each phase were used. Forty prospective reconstruction images of 5-mm thickness for each phase were obtained. The images from each phase were interpreted separately for detection of hypervascular hepatocellular carcinoma by 3 observers independently who were unaware of tumor burden in the liver. Sensitivity, positive predictive value, and area under the receiver operating characteristic curve values for each arterial phase were calculated and compared statistically. Results: The mean sensitivity and positive predictive values for hypervascular hepatocellular carcinoma diagnosis of blind readers were 37% and 87% for the early arterial phase, 73% and 85% for the middle arterial phase, and 49% and 81% for the late arterial phase, respectively. The middle arterial phase imaging showed significantly superior sensitivity compared with the early and late arterial phase for detecting hepatocellular carcinoma (P < 0.05). Mean area under the receiver operating characteristic curve value of the middle arterial phase imaging (0.84) was significantly higher that that of the early (0.56) or late arterial phase (0.62; P < 0.05). Conclusion: If a single arterial phase is used for diagnosis of hypervascular hepatocellular carcinoma, the middle phase (delay time of 30 seconds) is optimal.
    LIPPINCOTT WILLIAMS & WILKINS, 2003年08月, INVESTIGATIVE RADIOLOGY, 38(8) (8), 497 - 503, 英語
    [査読有り]
    研究論文（学術雑誌）

  • J Shimizu, H Oka, K Dono, M Sakon, M Takamura, T Murakami, S Hayashi, H Nagano, S Nakamori, K Umeshita, S Sase, M Gotoh, K Wakasa, H Nakamura, M Monden
    The aim of this study was to quantitatively measure tissue blood flow (TBF) in hepatocellular carcinoma (HCC) by a noninvasive method using xenon (Xe) inhalation/CT scans and to correlate the measured TBF with histological features. TBF was measured in HCC with xenon-enhanced CT (xenon/CT) in 20 patients. In 15 patients with HCC diagnosed as hypervascular tumors by conventional CT, TBF of the tumors was significantly higher than that of noncancerous liver tissue (151.1 +/- 20 vs 42.6 +/- 20 ml/min/100 g). Histologically, these tumors were diagnosed as moderately-to-poorly differentiated HCC. In contrast, in five patients with hypovascular HCC, TBF of HCC was almost comparable to that of the noncancerous regions (45.3 +/- 6 vs 48.3 +/- 6 ml/min/100 g). All these tumors were well-differentiated HCC. In conclusions, the measured values of TBF correlate with the clinicopathologic features of liver tumors and nontumorous liver tissue in patients with HCC.
    KLUWER ACADEMIC/PLENUM PUBL, 2003年08月, DIGESTIVE DISEASES AND SCIENCES, 48(8) (8), 1510 - 1516, 英語
    [査読有り]
    研究論文（学術雑誌）

  • AA Khankan, M Maeda, K Osuga, T Murakami, H Nakamura
    We report a case of left external iliac artery lesions as a complication of post-kidney transplantation due to vascular clamp application injury. The lesions were proximal stenosis and distal occlusion just near the graft anastomosis site and they were diagnosed incidentally during the embolization for arteriovenous fistula. Angiography confirmed the diagnosis and it was managed successfully by percutaneous interventional techniques.
    SPRINGER-VERLAG, 2003年03月, CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 26(2) (2), 186 - 188, 英語
    研究論文（学術雑誌）

  • E Sugihara, T Murakami, T Kim, M Hori, M Takamura, S Kawata, A Okada, AA Khankan, K Tomoda, H Nakamura
    Purpose: The technique of double-phase echo chemical shift gradient-echo magnetic resonance (MR) imaging with the fast low-angle shot sequence (double-echo FLASH) provides in-phase and opposed-phase (double-phase) images simultaneously. The purpose of this study was to assess whether the dynamic study with a combination of in-phase and opposed-phase (double-phase) echo images improves the detectability of hypervascular hepatocellular carcinoma (HCC) compared with that with either in-phase or opposed-phase images alone. Method: Thirty-seven patients with 107 hypervascular HCCs who underwent the whole-liver double-phase echo dynamic MR imaging were enrolled in the study. Three radiologists blindly read in-phase images alone, opposed-phase images alone, and then double-phase images together. Sensitivity and positive predictive values as well as the areas below the alternative-free response receiver operating characteristic curve (Az values) for each imaging technique were calculated and compared statistically. Results: The mean sensitivity, positive predictive values, and Az values for hypervascular HCCs were 51%, 77%, and 0.52 for in-phase imaging; 55%, 86%, and 0.58 for opposed-phase imaging; and 57%, 84%, and 0.63 for double-phase imaging, respectively. The mean sensitivity for opposed-phase imaging was significantly higher than that for in-phase imaging (P < 0.05), and the mean sensitivity for double-phase imaging was higher than that for in-phase imaging (P < 0.01). The mean Az value for the double-phase imaging was significantly higher than that for in-phase imaging (P < 0.01). Conclusion: Dynamic MR imaging with double-phase images was recommended for the detection of hypervascular HCC.
    LIPPINCOTT WILLIAMS & WILKINS, 2003年03月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 27(2) (2), 110 - 116, 英語
    研究論文（学術雑誌）

  • AA Khankan, M Maeda, K Osuga, T Murakami, H Nakamura
    We report a case of left external iliac artery lesions as a complication of post-kidney transplantation due to vascular clamp application injury. The lesions were proximal stenosis and distal occlusion just near the graft anastomosis site and they were diagnosed incidentally during the embolization for arteriovenous fistula. Angiography confirmed the diagnosis and it was managed successfully by percutaneous interventional techniques.
    SPRINGER-VERLAG, 2003年03月, CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 26(2) (2), 186 - 188, 英語
    [査読有り]
    研究論文（学術雑誌）

  • E Sugihara, T Murakami, T Kim, M Hori, M Takamura, S Kawata, A Okada, AA Khankan, K Tomoda, H Nakamura
    Purpose: The technique of double-phase echo chemical shift gradient-echo magnetic resonance (MR) imaging with the fast low-angle shot sequence (double-echo FLASH) provides in-phase and opposed-phase (double-phase) images simultaneously. The purpose of this study was to assess whether the dynamic study with a combination of in-phase and opposed-phase (double-phase) echo images improves the detectability of hypervascular hepatocellular carcinoma (HCC) compared with that with either in-phase or opposed-phase images alone. Method: Thirty-seven patients with 107 hypervascular HCCs who underwent the whole-liver double-phase echo dynamic MR imaging were enrolled in the study. Three radiologists blindly read in-phase images alone, opposed-phase images alone, and then double-phase images together. Sensitivity and positive predictive values as well as the areas below the alternative-free response receiver operating characteristic curve (Az values) for each imaging technique were calculated and compared statistically. Results: The mean sensitivity, positive predictive values, and Az values for hypervascular HCCs were 51%, 77%, and 0.52 for in-phase imaging; 55%, 86%, and 0.58 for opposed-phase imaging; and 57%, 84%, and 0.63 for double-phase imaging, respectively. The mean sensitivity for opposed-phase imaging was significantly higher than that for in-phase imaging (P < 0.05), and the mean sensitivity for double-phase imaging was higher than that for in-phase imaging (P < 0.01). The mean Az value for the double-phase imaging was significantly higher than that for in-phase imaging (P < 0.01). Conclusion: Dynamic MR imaging with double-phase images was recommended for the detection of hypervascular HCC.
    LIPPINCOTT WILLIAMS & WILKINS, 2003年03月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 27(2) (2), 110 - 116, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Esophageal varices: Diagnosis with gadolinium-enhanced MR imaging of the liver for patients with chronic liver damage
    M Matsuo, M Kanematsu, T Kim, M Hori, M Takamura, T Murakami, H Kondo, N Moriyama, H Nakamura, H Hoshi
    OBJECTIVE. The purpose of our study was to evaluate the value of gadolinium-enhanced MR imaging of the liver in the detection and grading of esophageal varices in patients with chronic liver damage. MATERIALS AND METHODS. Three independent off-site radiologists retrospectively reviewed MR images of the liver obtained in 72 patients with chronic liver damage, including 49 patients with untreated esophageal varices. All patients had undergone gastrointestinal endoscopy within 2 weeks of MR imaging. Both MR and endoscopic images were reviewed to determine whether esophageal varices were present and, if so, to determine the grade of the varices. Observer performances were tested with reciever operating characteristic curve analysis using the jackknife dispersion test. Correlations between the grades of the varices determined using MR images and those determined using endoscopic images were tested. RESULTS. Sensitivity for detection of esophageal varices was significantly (p < 0.01) higher for the combination of unenhanced and gadolinium-enhanced MR images (81%) than for the unenhanced MR images alone (51%). The receiver operating characteristic curve analysis (area under the curve, [A(z)]) showed that performance using the combination of the unenhanced and gadolinium-enhanced MR images (A(z) = 0.641) was superior to that using unenhanced MR images alone (A(z) = 0.586). A statistically significant positive correlation (p < 0.05) was found between the grades determined using MR imaging and the grades determined using endoscopy. CONCLUSION. Our results suggest the potential value of diagnosing the presence and grade of esophageal varices on MR imaging of the liver for patients with chronic liver damage. Gadolinium-enhanced MR imaging may increase the potential value.
    AMER ROENTGEN RAY SOC, 2003年02月, AMERICAN JOURNAL OF ROENTGENOLOGY, 180(2) (2), 461 - 466, 英語
    研究論文（学術雑誌）

  • Detection of hepatocellular carcinoma: Comparison of dynamic MR imaging with dynamic double arterial phase helical CT
    Y Noguchi, T Murakami, T Kim, M Hori, K Osuga, S Kawata, S Kumano, A Okada, T Sugiura, H Nakamura
    OBJECTIVE. Three-dimensional (313) Fourier transformation-enhanced fast gradient-echo sequences with a special spectral inversion recovery pulse and fat suppression developed for abdominal imaging, including MR angiography, can show enhanced areas clearly. The purpose of this study was to evaluate the efficacy of dynamic MR imaging with the pulse sequences for the detection of hypervascular hepatocellular carcinoma by comparing it with that of dynamic helical CT with double arterial phase imaging. SUBJECTS AND METHODS. Fifty-three patients with 103 hypervascular hepatocellular carcinoma nodules who underwent both dynamic MR imaging with 3D Fourier transformation-enhanced fast gradient-echo sequences with a special spectral inversion recovery pulse and dynamic helical CT with double arterial phase imaging were enrolled in the study. For dynamic MR imaging, unenhanced, arterial, portal venous, and equilibrium phase images were obtained before and approximately 19, 60, and 120 sec, respectively, after injection of gadopentetate dimeglumine. Three observers independently interpreted the images obtained with each technique in a blinded manner and in random order. RESULTS. Mean sensitivity and positive predictive values of CT for hypervascular hepatocellular carcinoma (66% and 97%, respectively) were higher than those of MR imaging (63% and 96%, respectively), but there was no significant difference in detecting sensitivity among the observers (p < 0.05). CT and MR imaging were complementary, with some tumors undetected by CT but revealed on MR imaging. There was also no significant difference in A(z) values between CT (0.74) and MR imaging (0.71) (p < 0.05). CONCLUSION. Dynamic MR imaging with 3D Fourier transformation-enhanced fast gradient-echo sequences with a special spectral inversion recovery pulse is recommended to improve the detection of hypervascular hepatocellular carcinoma nodules in addition to the use of dynamic helical CT with double arterial phase imaging.
    AMER ROENTGEN RAY SOC, 2003年02月, AMERICAN JOURNAL OF ROENTGENOLOGY, 180(2) (2), 455 - 460, 英語
    研究論文（学術雑誌）

  • Y Noguchi, T Murakami, T Kim, M Hori, K Osuga, S Kawata, S Kumano, A Okada, T Sugiura, H Nakamura
    OBJECTIVE. Three-dimensional (313) Fourier transformation-enhanced fast gradient-echo sequences with a special spectral inversion recovery pulse and fat suppression developed for abdominal imaging, including MR angiography, can show enhanced areas clearly. The purpose of this study was to evaluate the efficacy of dynamic MR imaging with the pulse sequences for the detection of hypervascular hepatocellular carcinoma by comparing it with that of dynamic helical CT with double arterial phase imaging. SUBJECTS AND METHODS. Fifty-three patients with 103 hypervascular hepatocellular carcinoma nodules who underwent both dynamic MR imaging with 3D Fourier transformation-enhanced fast gradient-echo sequences with a special spectral inversion recovery pulse and dynamic helical CT with double arterial phase imaging were enrolled in the study. For dynamic MR imaging, unenhanced, arterial, portal venous, and equilibrium phase images were obtained before and approximately 19, 60, and 120 sec, respectively, after injection of gadopentetate dimeglumine. Three observers independently interpreted the images obtained with each technique in a blinded manner and in random order. RESULTS. Mean sensitivity and positive predictive values of CT for hypervascular hepatocellular carcinoma (66% and 97%, respectively) were higher than those of MR imaging (63% and 96%, respectively), but there was no significant difference in detecting sensitivity among the observers (p < 0.05). CT and MR imaging were complementary, with some tumors undetected by CT but revealed on MR imaging. There was also no significant difference in A(z) values between CT (0.74) and MR imaging (0.71) (p < 0.05). CONCLUSION. Dynamic MR imaging with 3D Fourier transformation-enhanced fast gradient-echo sequences with a special spectral inversion recovery pulse is recommended to improve the detection of hypervascular hepatocellular carcinoma nodules in addition to the use of dynamic helical CT with double arterial phase imaging.
    AMER ROENTGEN RAY SOC, 2003年02月, AMERICAN JOURNAL OF ROENTGENOLOGY, 180(2) (2), 455 - 460, 英語
    [査読有り]

  • M Matsuo, M Kanematsu, T Kim, M Hori, M Takamura, T Murakami, H Kondo, N Moriyama, H Nakamura, H Hoshi
    OBJECTIVE. The purpose of our study was to evaluate the value of gadolinium-enhanced MR imaging of the liver in the detection and grading of esophageal varices in patients with chronic liver damage. MATERIALS AND METHODS. Three independent off-site radiologists retrospectively reviewed MR images of the liver obtained in 72 patients with chronic liver damage, including 49 patients with untreated esophageal varices. All patients had undergone gastrointestinal endoscopy within 2 weeks of MR imaging. Both MR and endoscopic images were reviewed to determine whether esophageal varices were present and, if so, to determine the grade of the varices. Observer performances were tested with reciever operating characteristic curve analysis using the jackknife dispersion test. Correlations between the grades of the varices determined using MR images and those determined using endoscopic images were tested. RESULTS. Sensitivity for detection of esophageal varices was significantly (p < 0.01) higher for the combination of unenhanced and gadolinium-enhanced MR images (81%) than for the unenhanced MR images alone (51%). The receiver operating characteristic curve analysis (area under the curve, [A(z)]) showed that performance using the combination of the unenhanced and gadolinium-enhanced MR images (A(z) = 0.641) was superior to that using unenhanced MR images alone (A(z) = 0.586). A statistically significant positive correlation (p < 0.05) was found between the grades determined using MR imaging and the grades determined using endoscopy. CONCLUSION. Our results suggest the potential value of diagnosing the presence and grade of esophageal varices on MR imaging of the liver for patients with chronic liver damage. Gadolinium-enhanced MR imaging may increase the potential value.
    AMER ROENTGEN RAY SOC, 2003年02月, AMERICAN JOURNAL OF ROENTGENOLOGY, 180(2) (2), 461 - 466, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 非剛体レジストレーションを適用した多時相腹部造影ＣＴ画像からの肝臓領域自動抽出法
    桝本潤, 村上 卓道
    2003年, コンピュータ支援画像診断学会論文誌, 7, 1 - 10

  • 5-FU,CDDP,Adriamycinの3剤併用動注療法によりCRが得られた進行肝細胞癌(Vp4,Vv3,IM3)の１例
    太田英夫, 村上 卓道
    2003年, 癌と化学療法, 30, 1673 - 1677

  • 超常磁性体酸化鉄製剤SH U 555AのMRI肝臓造影における用量検討
    廣橋伸治, 村上 卓道
    2003年, 日本医放会誌, 63, 539 - 550

  • 工藤 正幸, 村上 卓道, 堀 雅敏, 中村 仁信
    公益社団法人 日本放射線技術学会, 2003年, 日本放射線技術学会雑誌, 59(9) (9), 1032 - 1033, 日本語

  • Yumi Noguchi, Takamichi Murakami, Tonsok Kim, Masatoshi Hori, Keigo Osuga, Syuji Kawata, Atsuya Okada, Takashi Sugiura, Kaname Tomoda, Yoshifumi Narumi, Hironobu Nakamura
    Purpose: The technique of double-echo chemical shift gradient echo magnetic resonance imaging (MRI) with the fast low-angle shot (double-echo FLASH) sequence provides in-phase and opposed-phase images in a single breath hold. The purpose of this study was to evaluate the efficacy of dynamic MRI with double-echo FLASH imaging for the detection of hypervascular hepatocellular carcinoma by comparing it with dynamic helical computed tomography (CT) imaging with double arterial phase. Materials and Methods: Twenty-nine patients with 67 hypervascular hepatocellular carcinoma nodules who underwent both dynamic MRI with double-echo FLASH imaging (repetition time/echo time/flip angle: 160/3.6, 7.0/80c) and dynamic helical CT imaging with double arterial phase were enrolled in the study. For dynamic MRI, precontrast, arterial, portal venous, and equilibrium phase images were obtained before and approximately 19, 60, and 120 seconds, respectively, after intravenous injection of 0.1 mmol/kg of gadopentetate dimeglumine at a rate of 2 ml/s. For dynamic CT imaging, quadraphase images, including early arterial, late arterial, portal venous, and equilibrium phases, were obtained serially approximately 20, 30, 70, and 180 seconds, respectively, after intravenous administration of 2 ml/kg of 300 mgI/ml of nonionic contrast medium at a rate of 5 ml/s. Three masked observers independently interpreted images obtained with each technique in random order, separately and without patient identifiers. Sensitivity and positive predictive values as well as the area below the alternative-free response receiver operating characteristic curve (Az) for each imaging technique were calculated and compared statistically. Results: Mean sensitivity and positive predictive values of MRI for hypervascular hepatocellular carcinoma were 48% and 94%, respectively, and those of CT imaging were 47% and 91%, respectively. In 11 (38%) of the 29 patients, at least one observer judged dynamic MRI to be superior, whereas in 5 patients (17%), dynamic CT was judged to be superior. There was no significant difference in the sensitivity and positive predictive values between these techniques (p > 0.05). There was no significant difference either in mean Az values between CT (0.55) and MRI (0.57) (p = 0.61). Conclusion: Dynamic MRI with double-echo FLASH imaging can detect hypervascular hepatocellular carcinoma as well as dynamic helical CT imaging with double arterial phase.
    2002年11月, Journal of Computer Assisted Tomography, 26(6) (6), 981 - 987, 英語
    研究論文（学術雑誌）

  • Embolization of high flow arteriovenous malformations: Experience with use of superabsorbent polymer microspheres
    K Osuga, S Hori, H Kitayoshi, AA Khankan, A Okada, T Sugiura, T Murakami, K Hosokawa, H Nakamura
    PURPOSE: To determine efficacy, safety, and requirements for adjunctive embolization or surgery in the treatment of symptomatic arteriovenous malformations (AVMs) with superabsorbent polymer microsphere (SAP-MS) particles. MATERIALS AND METHODS: SAP-MS particles (sodium acrylate and vinyl alcohol copolymer) are nonbiodegradable spheres with a precisely calibrated diameter. SAP-MS particles swell by absorbing fluids and become soft and deformable. Twenty-five patients (16 men, nine women; mean age, 32 y; range 12-66 y) with symptomatic facial (n = 5), upper- (n = 8) and lower- (n = 12) extremity AVMs were treated primarily (n = 23) or preoperatively (n = 2) by transarterial embolization (TAE) treatment with use of SAP-MS particles. Direct puncture embolization (DPE; n = 4) and/or surgical intervention (n = 5; ie, skin graft, resection, or amputation) were required. Surgical specimens from the resected (n = 2) and the amputated (n = 2) patients were evaluated histologically. Follow-up study, including clinical findings and imaging studies, was performed at intervals ranging from 3 months to 1 year. Clinical outcome was evaluated retrospectively, depending on the subjective improvement of symptoms and signs, according to the medical records. RESULTS: Seventy-two TAEs (range, 1-11; mean, 2.8) and 12 DPEs (range, 1-3; mean, 2.4) were performed during the mean follow-up period of 38 months (range, 7-110 mo). Twenty patients (80%) experienced symptom improvement by embolotherapy alone (n = 17) or in combination with surgery (n = 3). One lip and two finger AVMs were totally removed by surgical excision or amputation after TAE treatment. In diffuse upper- (n = 1) and lower- (n = 1) extremity AVMs, the symptoms were uncontrolled. No nerve injury or skin necrosis was observed after TAE treatment with SAP-MS particles. Mucosal necrosis was induced by DPE with ethanol in one patient. Histologically, SAP-MS particles penetrated intralesional vessels and conformed to the vessel lumen, resulting in tight vessel occlusion. Minimal perivascular reaction was observed. CONCLUSION: SAP-MS particles were used safely in TAE treatment of AVM. TAE treatment with use of SAP-MS particles was suitable for certain symptomatic AVMs, but diffuse AVMs remain a challenge and a combination of alternative methods will be necessary for further strategy.
    LIPPINCOTT WILLIAMS & WILKINS, 2002年11月, JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 13(11) (11), 1125 - 1133, 英語
    研究論文（学術雑誌）

  • Embolization of high flow arteriovenous malformations: Experience with use of superabsorbent polymer microspheres
    K Osuga, S Hori, H Kitayoshi, AA Khankan, A Okada, T Sugiura, T Murakami, K Hosokawa, H Nakamura
    PURPOSE: To determine efficacy, safety, and requirements for adjunctive embolization or surgery in the treatment of symptomatic arteriovenous malformations (AVMs) with superabsorbent polymer microsphere (SAP-MS) particles. MATERIALS AND METHODS: SAP-MS particles (sodium acrylate and vinyl alcohol copolymer) are nonbiodegradable spheres with a precisely calibrated diameter. SAP-MS particles swell by absorbing fluids and become soft and deformable. Twenty-five patients (16 men, nine women; mean age, 32 y; range 12-66 y) with symptomatic facial (n = 5), upper- (n = 8) and lower- (n = 12) extremity AVMs were treated primarily (n = 23) or preoperatively (n = 2) by transarterial embolization (TAE) treatment with use of SAP-MS particles. Direct puncture embolization (DPE; n = 4) and/or surgical intervention (n = 5; ie, skin graft, resection, or amputation) were required. Surgical specimens from the resected (n = 2) and the amputated (n = 2) patients were evaluated histologically. Follow-up study, including clinical findings and imaging studies, was performed at intervals ranging from 3 months to 1 year. Clinical outcome was evaluated retrospectively, depending on the subjective improvement of symptoms and signs, according to the medical records. RESULTS: Seventy-two TAEs (range, 1-11; mean, 2.8) and 12 DPEs (range, 1-3; mean, 2.4) were performed during the mean follow-up period of 38 months (range, 7-110 mo). Twenty patients (80%) experienced symptom improvement by embolotherapy alone (n = 17) or in combination with surgery (n = 3). One lip and two finger AVMs were totally removed by surgical excision or amputation after TAE treatment. In diffuse upper- (n = 1) and lower- (n = 1) extremity AVMs, the symptoms were uncontrolled. No nerve injury or skin necrosis was observed after TAE treatment with SAP-MS particles. Mucosal necrosis was induced by DPE with ethanol in one patient. Histologically, SAP-MS particles penetrated intralesional vessels and conformed to the vessel lumen, resulting in tight vessel occlusion. Minimal perivascular reaction was observed. CONCLUSION: SAP-MS particles were used safely in TAE treatment of AVM. TAE treatment with use of SAP-MS particles was suitable for certain symptomatic AVMs, but diffuse AVMs remain a challenge and a combination of alternative methods will be necessary for further strategy.
    LIPPINCOTT WILLIAMS & WILKINS, 2002年11月, JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 13(11) (11), 1125 - 1133, 英語
    [査読有り]
    研究論文（学術雑誌）

  • [A case of postoperative multiple hepatic metastasis from gastric cancer successfully treated by percutaneous microwave coagulation therapy and hepatic arterial infusion chemotherapy].
    Yamamoto T, Nagano H, Sakon M, Yasuda T, Takemoto H, Tsujino T, Ota H, Dono K, Umeshita K, Nakamori S, Yano M, Osuga K, Murakami T, Nakamura H, Monden M
    12, 2002年11月, Gan to kagaku ryoho. Cancer & chemotherapy, 29, 2429 - 2432
    [査読有り]

  • Y Noguchi, T Murakami, T Kim, M Hori, K Osuga, S Kawata, A Okada, T Sugiura, K Tomoda, Y Narumi, H Nakamura
    Purpose: The technique of double-echo chemical shift gradient echo magnetic resonance imaging (MRI) With the fast low-angle shot (double-echo FLASH) sequence provides in-phase and opposed-phase images in a single breath hold. The purpose of this study was to evaluate the efficacy of dynamic MRI with double-echo FLASH imaging for the detection of hypervascular hepatocellular carcinoma by comparing it With dynamic helical computed tomography (CT) imaging With double arterial phase. Materials and Methods: Twenty-nine patients with 67 hypervascular hepatocellular carcinoma nodules Who underwent both dynamic MRI with double-echo FLASH imaging (repetition time/echo time/flip angle: 160/3.6, 7.0/80degrees) and dynamic helical CT imaging with double arterial phase were enrolled in the study. For dynamic MRI, precontrast, arterial. portal venous, and equilibrium phase images were obtained before and approximately 19, 60, and 120 seconds, respectively, after intravenous injection of 0.1 mmol/kg of gadopentetate dimeglumine at a rate of 2 ml/s. For dynamic CT imaging, quadraphase images, including early arterial, late arterial, portal venous, and equilibrium phases, were obtained serially approximately 20, 30, 70, and 180 seconds, respectively, after intravenous administration of 2 ml/kg of 300 mgl/ml of nonionic contrast medium at a rate of 5 ml/s. Three masked observers independently interpreted images obtained With each technique in random order, separately and without patient identifiers. Sensitivity and positive predictive values as well as the area below the alternative-free response receiver operating characteristic curve (Az) for each imaging technique were calculated and compared statistically. Results: Mean sensitivity and positive predictive values of MRI for hypervascular hepatocellular carcinoma Were 48% and 94%, respectively, and those of CT imaging were 47% and 91%, respectively. In 11 (38%) of the 29 patients, at least one observer judged dynamic MRI to be superior, whereas in 5 patients (17%), dynamic CT was judged to be superior. There was no significant difference in the sensitivity and positive predictive values between these techniques (p > 0.05). There was no significant difference either in mean Az values between CT (0.55) and MRI (0.57) (p = 0.61). Conclusion: Dynamic MRI with double-echo FLASH imaging can detect hypervascular hepatocellular carcinoma as well as dynamic helical CT imaging with double arterial phase.
    LIPPINCOTT WILLIAMS & WILKINS, 2002年11月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 26(6) (6), 981 - 987, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M Hori, T Murakami, T Kim, K Tsuda, S Takahashi, A Okada, M Takamura, H Nakamura
    Purpose: The purpose of this study was to compare the diagnostic performance of superparamagnetic iron oxide (SPIO)-enhanced MRI for the detection of hypervascular hepatocellular carcinoma (HCC) with dynamic helical CT. Methods: SPIO-enhanced MR and dynamic helical CT images obtained from 41 patients with 52 hypervascular HCCs (5-130 mm; mean, 27 mm) were retrospectively analyzed. MRI were obtained with 1.5 T scanners using T2-weighted and proton density-weighted spin-echo (or fast spin-echo) sequences for all cases and a T2*-weighted gradient echo sequence for 36 cases. Four blinded observers reviewed images independently. Diagnostic accuracy was evaluated using alternative-free response receiver operating characteristic (AFROC) method. Sensitivities and positive predictive values (PPV) were also evaluated. Results: The areas under the AFROC curves for each observer were greater for MR than for CT (means, 0.81 and 0.76; p < 0.05). The mean sensitivities for MR and CT were 0.75 and 0.71, respectively (p = 0.13). The mean PPVs were 0.83 and 0.79 (p = 0.21). Conclusion: SPIO-enhanced MRI showed slightly better diagnostic performance than dynamic helical CT for the detection of hypervascular HCCs.
    LIPPINCOTT WILLIAMS & WILKINS, 2002年09月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 26(5) (5), 701 - 710, 英語
    研究論文（学術雑誌）

  • Transarterial embolization for large hepatocellular carcinoma with use of superabsorbent polymer microspheres: Initial experience
    K Osuga, AA Khankan, S Hori, A Okada, T Sugiura, M Maeda, H Nagano, A Yamada, T Murakami, H Nakamura
    The authors report the initial experience with transarterial embolization of large hepatocellular carcinoma (HCC) with use of superabsorbent polymer microsphere (SAP-MS) particles. Six patients with nine HCCs (mean diameter, 8.2 cm) underwent 10 embolization procedures. Two patients underwent surgery later. In follow-up, tumor necrosis, postembolization syndrome, and laboratory data were assessed. Complete necrosis in three nodules, nearly complete necrosis in three nodules, and partial necrosis in three nodules were observed. Histologically, SAP-MS occluded intratumoral vessels tightly without ischemic damage of normal hepatic tissue. Postprocedural pain was minimal. No deterioration of liver function occurred. Our initial experience suggests that embolization with use of SAP-MS leads to extensive tumor necrosis of large nodular HCC, sparing use of chemotherapeutic agents.
    LIPPINCOTT WILLIAMS & WILKINS, 2002年09月, JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 13(9) (9), 929 - 934, 英語
    研究論文（学術雑誌）

  • Transarterial embolization for large hepatocellular carcinoma with use of superabsorbent polymer microspheres: Initial experience
    K Osuga, AA Khankan, S Hori, A Okada, T Sugiura, M Maeda, H Nagano, A Yamada, T Murakami, H Nakamura
    The authors report the initial experience with transarterial embolization of large hepatocellular carcinoma (HCC) with use of superabsorbent polymer microsphere (SAP-MS) particles. Six patients with nine HCCs (mean diameter, 8.2 cm) underwent 10 embolization procedures. Two patients underwent surgery later. In follow-up, tumor necrosis, postembolization syndrome, and laboratory data were assessed. Complete necrosis in three nodules, nearly complete necrosis in three nodules, and partial necrosis in three nodules were observed. Histologically, SAP-MS occluded intratumoral vessels tightly without ischemic damage of normal hepatic tissue. Postprocedural pain was minimal. No deterioration of liver function occurred. Our initial experience suggests that embolization with use of SAP-MS leads to extensive tumor necrosis of large nodular HCC, sparing use of chemotherapeutic agents.
    LIPPINCOTT WILLIAMS & WILKINS, 2002年09月, JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 13(9) (9), 929 - 934, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M Hori, T Murakami, T Kim, K Tsuda, S Takahashi, A Okada, M Takamura, H Nakamura
    Purpose: The purpose of this study was to compare the diagnostic performance of superparamagnetic iron oxide (SPIO)-enhanced MRI for the detection of hypervascular hepatocellular carcinoma (HCC) with dynamic helical CT. Methods: SPIO-enhanced MR and dynamic helical CT images obtained from 41 patients with 52 hypervascular HCCs (5-130 mm; mean, 27 mm) were retrospectively analyzed. MRI were obtained with 1.5 T scanners using T2-weighted and proton density-weighted spin-echo (or fast spin-echo) sequences for all cases and a T2*-weighted gradient echo sequence for 36 cases. Four blinded observers reviewed images independently. Diagnostic accuracy was evaluated using alternative-free response receiver operating characteristic (AFROC) method. Sensitivities and positive predictive values (PPV) were also evaluated. Results: The areas under the AFROC curves for each observer were greater for MR than for CT (means, 0.81 and 0.76; p < 0.05). The mean sensitivities for MR and CT were 0.75 and 0.71, respectively (p = 0.13). The mean PPVs were 0.83 and 0.79 (p = 0.21). Conclusion: SPIO-enhanced MRI showed slightly better diagnostic performance than dynamic helical CT for the detection of hypervascular HCCs.
    LIPPINCOTT WILLIAMS & WILKINS, 2002年09月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 26(5) (5), 701 - 710, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Multidetector CT: Diagnostic impact of slice thickness on detection of hypervascular hepatocellular carcinoma
    S Kawata, T Murakami, T Kim, M Hori, MP Federle, S Kumano, E Sugihara, S Makino, H Nakamura, M Kudo
    OBJECTIVE. The objective of our study was to evaluate the diagnostic impact of varying slice thickness on multidetector CT to optimize detection of hypervascular hepatocellular carcinoma. MATERIALS AND METHODS. Forty-three patients with 87 hypervascular hepatocellular carcinomas (diameter: range, 3-80 mm; mean, 22 mm) and 19 patients with either chronic hepatitis or liver cirrhosis and without hepatocellular carcinoma who had undergone early arterial and late arterial phase imaging of the entire liver on multidetector CT were retrospectively enrolled in this study. The detector row configuration was 2.5 x 4 mm, the pitch was 6, and the scanning time was 10.5 sec for each phase. All patients received contrast medium (2 mL/kg of body weight) at a rate of 5 mL/sec; the mean scanning delay for the early arterial phase was 19.0 sec, and the mean delay for the late arterial phase was 34.5 sec. Eighty 2.5-mm-thick reconstruction images, forty 5-mm-thick reconstruction images, and twenty-six 7.5-mm-thick reconstruction images were obtained for each phase. Each image set was interpreted separately by three observers to detect hypervascular hepatocellular carcinoma by viewing images on a workstation monitor. Sensitivity, positive predictive value, and area under the receiver operating characteristic curve (A(z)) were calculated. We used retrospectively excellent follow-up and imaging or pathologic proof as the gold standard. RESULTS. The mean sensitivity and positive predictive value for hypervascular hepatocellular carcinoma were 76% and 69% on 2.5-mm images, 73% and 69% on 5-mm, images, and 67% and 76% on 7.5-mm images, respectively. No significant difference in sensitivity among the images was detected, except by one observer who reported a significant difference in the sensitivity between 2.5- and 7.5-mm images (p < 0.05) and between 5- and 7.5-mm images (p < 0.05). The mean A(z) values were 0.79, 0.80, and 0.78 for 2.5-, 5-, and 7.5-mm images, respectively. No significant difference in A(z) values among the images obtained with different slice thicknesses was detected. CONCLUSION. For multidetector CT identification of hypervascular hepatocellular carcinoma, we found little or no advantage in reducing slice thickness to less than 5 mm.
    AMER ROENTGEN RAY SOC, 2002年07月, AMERICAN JOURNAL OF ROENTGENOLOGY, 179(1) (1), 61 - 66, 英語
    研究論文（学術雑誌）

  • S Kawata, T Murakami, T Kim, M Hori, MP Federle, S Kumano, E Sugihara, S Makino, H Nakamura, M Kudo
    OBJECTIVE. The objective of our study was to evaluate the diagnostic impact of varying slice thickness on multidetector CT to optimize detection of hypervascular hepatocellular carcinoma. MATERIALS AND METHODS. Forty-three patients with 87 hypervascular hepatocellular carcinomas (diameter: range, 3-80 mm; mean, 22 mm) and 19 patients with either chronic hepatitis or liver cirrhosis and without hepatocellular carcinoma who had undergone early arterial and late arterial phase imaging of the entire liver on multidetector CT were retrospectively enrolled in this study. The detector row configuration was 2.5 x 4 mm, the pitch was 6, and the scanning time was 10.5 sec for each phase. All patients received contrast medium (2 mL/kg of body weight) at a rate of 5 mL/sec; the mean scanning delay for the early arterial phase was 19.0 sec, and the mean delay for the late arterial phase was 34.5 sec. Eighty 2.5-mm-thick reconstruction images, forty 5-mm-thick reconstruction images, and twenty-six 7.5-mm-thick reconstruction images were obtained for each phase. Each image set was interpreted separately by three observers to detect hypervascular hepatocellular carcinoma by viewing images on a workstation monitor. Sensitivity, positive predictive value, and area under the receiver operating characteristic curve (A(z)) were calculated. We used retrospectively excellent follow-up and imaging or pathologic proof as the gold standard. RESULTS. The mean sensitivity and positive predictive value for hypervascular hepatocellular carcinoma were 76% and 69% on 2.5-mm images, 73% and 69% on 5-mm, images, and 67% and 76% on 7.5-mm images, respectively. No significant difference in sensitivity among the images was detected, except by one observer who reported a significant difference in the sensitivity between 2.5- and 7.5-mm images (p < 0.05) and between 5- and 7.5-mm images (p < 0.05). The mean A(z) values were 0.79, 0.80, and 0.78 for 2.5-, 5-, and 7.5-mm images, respectively. No significant difference in A(z) values among the images obtained with different slice thicknesses was detected. CONCLUSION. For multidetector CT identification of hypervascular hepatocellular carcinoma, we found little or no advantage in reducing slice thickness to less than 5 mm.
    AMER ROENTGEN RAY SOC, 2002年07月, AMERICAN JOURNAL OF ROENTGENOLOGY, 179(1) (1), 61 - 66, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Small hypervascular hepatocellular carcinoma revealed by double arterial phase CT performed with single breath-hold scanning and automatic bolus tracking
    T Kim, T Murakami, M Hori, M Takamura, S Takahashi, A Okada, S Kawata, M Cruz, MP Federle, H Nakamura
    OBJECTIVE. The purpose of this study was to evaluate the usefulness of double arterial phase CT for the detection of small hypervascular hepatocellular carcinomas, using an automated bolus-tracking technique to initiate the hepatic arterial phase CT. MATERIALS AND METHODS. Double arterial and late phase contrast-enhanced helical CT scans were obtained on 287 consecutive patients suspected of having hepatocellular carcinoma. These included 56 patients with 90 small (less than or equal to3 cm) hepatocellular carcinomas and 50 patients with no hepatocellular carcinomas. CT scans of these patients were interpreted by three reviewers. The first arterial phase scan was initiated automatically 10 sec after the bolus-tracking program detected the threshold enhancement of 50 H in the abdominal aorta. Three. reviewers interpreted the late phase CT scans in combination with the first, second, or both hepatic arterial phases. Measures of the reviewers detection of hepatocellular carcinoma included analysis of interobserver variation, sensitivity, specificity, and area under receiver operating characteristic curve (A(z)). RESULTS. The time elapsed from bolus initiation to threshold aortic enhancement ranged from 10 to 24 sec (mean, 13 see), resulting in initiation of the first arterial phase CT scan from 20 to 34 see (mean, 23 see). The combination of late phase CT and both first and second arterial phase images showed significantly better performance than the combination of the late phase and either the first or second arterial phases, although the difference was most evident in comparison with the combination of second arterial and late phases. CONCLUSION. An automated bolus-tracking program can be used to optimize the timing of hepatic arterial phase CT. Multiphasic CT performed using this technique is useful in detection of small hepatocellular carcinoma.
    AMER ROENTGEN RAY SOC, 2002年04月, AMERICAN JOURNAL OF ROENTGENOLOGY, 178(4) (4), 899 - 904, 英語
    研究論文（学術雑誌）

  • T Kim, T Murakami, M Hori, M Takamura, S Takahashi, A Okada, S Kawata, M Cruz, MP Federle, H Nakamura
    OBJECTIVE. The purpose of this study was to evaluate the usefulness of double arterial phase CT for the detection of small hypervascular hepatocellular carcinomas, using an automated bolus-tracking technique to initiate the hepatic arterial phase CT. MATERIALS AND METHODS. Double arterial and late phase contrast-enhanced helical CT scans were obtained on 287 consecutive patients suspected of having hepatocellular carcinoma. These included 56 patients with 90 small (less than or equal to3 cm) hepatocellular carcinomas and 50 patients with no hepatocellular carcinomas. CT scans of these patients were interpreted by three reviewers. The first arterial phase scan was initiated automatically 10 sec after the bolus-tracking program detected the threshold enhancement of 50 H in the abdominal aorta. Three. reviewers interpreted the late phase CT scans in combination with the first, second, or both hepatic arterial phases. Measures of the reviewers detection of hepatocellular carcinoma included analysis of interobserver variation, sensitivity, specificity, and area under receiver operating characteristic curve (A(z)). RESULTS. The time elapsed from bolus initiation to threshold aortic enhancement ranged from 10 to 24 sec (mean, 13 see), resulting in initiation of the first arterial phase CT scan from 20 to 34 see (mean, 23 see). The combination of late phase CT and both first and second arterial phase images showed significantly better performance than the combination of the late phase and either the first or second arterial phases, although the difference was most evident in comparison with the combination of second arterial and late phases. CONCLUSION. An automated bolus-tracking program can be used to optimize the timing of hepatic arterial phase CT. Multiphasic CT performed using this technique is useful in detection of small hepatocellular carcinoma.
    AMER ROENTGEN RAY SOC, 2002年04月, AMERICAN JOURNAL OF ROENTGENOLOGY, 178(4) (4), 899 - 904, 英語
    [査読有り]
    研究論文（学術雑誌）

  • H Yoshimura, T Murakami, T Kim, H Nakamura, N Hirabuki, M Sakon, K Wakasa, Y Inoue
    We report two cases of angiomyolipoma of the liver, where small amounts of fat on computed tomography, magnetic resonance imaging, and angiography made distinguishing this tumor from other hypervascular tumors difficult. Recognizing the imaging features of no capsule, hypervascularity of the tumor including the fat component, and early venous drainage may be helpful for correctly diagnosing angiomyolipoma of the liver.
    SPRINGER-VERLAG, 2002年03月, ABDOMINAL IMAGING, 27(2) (2), 184 - 187, 英語
    研究論文（学術雑誌）

  • Percutaneous microwave tumor coagulation for hepatocellular carcinomas with interruption of segmental hepatic blood flow
    T Ishida, T Murakami, T Shibata, Y Inoue, M Takamura, T Niinobu, T Sato, H Nakamura
    PURPOSE: To assess the effect of hepatic artery occlusion with or without hepatic venous outflow interruption on coagulation diameter during percutaneous microwave coagulation therapy (PMCT) for hepatocellular carcinoma (HCC) by a prospective and randomized trial. MATERIALS AND METHODS: Thirty-one patients with 36 HCCs (10-38 mm in diameter) were randomly separated into two treatment groups as follows: group 1 (14 tumors in 14 patients) was treated with PMCT in conjunction with both segmental hepatic artery embolization with gelatin sponge particles and temporary interruption of hepatic venous flow by means of a 6-F balloon catheter to reduce the portal venous flow; group 2 (22 tumors in 17 patients) was treated with PMCT with segmental hepatic artery embolization only. PMCT under ultrasound (US) guidance was performed with 2,450 MHz of microwave frequency at 40-60 W and a needle applicator 1.6 mm in diameter. The coagulated area was measured at the maximum diameter perpendicular to the needle tract on enhanced computed tomography (CT) performed immediately after PMCT. The local effect of the treatment was evaluated by follow-up enhanced CT (6-33 mo). RESULTS: Patients in group I had a significantly larger coagulation area (mean +/- SD = 42.9 mm +/- 8.3), with coagulation times of 5.3 min +/- 1.4, than patients in group 2 (32.6 mm +/- 8.0), with coagulation times of 4.2 min +/- 1.3 (P <.05). Follow-up enhanced CT showed no local enhancement of the tumor, indicating complete necrosis and no local recurrence, except for four tumors. There were no major complications after PMCT except liver abscess that developed after PMCT in one patient with pneumobilia. CONCLUSIONS: PMCT with combined hepatic arterial embolization and temporary hepatic venous flow interruption can coagulate significantly larger volumes of tumor than PMCT with only hepatic arterial embolization.
    LIPPINCOTT WILLIAMS & WILKINS, 2002年02月, JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 13(2) (2), 185 - 191, 英語
    研究論文（学術雑誌）

  • Percutaneous microwave tumor coagulation for hepatocellular carcinomas with interruption of segmental hepatic blood flow
    T Ishida, T Murakami, T Shibata, Y Inoue, M Takamura, T Niinobu, T Sato, H Nakamura
    PURPOSE: To assess the effect of hepatic artery occlusion with or without hepatic venous outflow interruption on coagulation diameter during percutaneous microwave coagulation therapy (PMCT) for hepatocellular carcinoma (HCC) by a prospective and randomized trial. MATERIALS AND METHODS: Thirty-one patients with 36 HCCs (10-38 mm in diameter) were randomly separated into two treatment groups as follows: group 1 (14 tumors in 14 patients) was treated with PMCT in conjunction with both segmental hepatic artery embolization with gelatin sponge particles and temporary interruption of hepatic venous flow by means of a 6-F balloon catheter to reduce the portal venous flow; group 2 (22 tumors in 17 patients) was treated with PMCT with segmental hepatic artery embolization only. PMCT under ultrasound (US) guidance was performed with 2,450 MHz of microwave frequency at 40-60 W and a needle applicator 1.6 mm in diameter. The coagulated area was measured at the maximum diameter perpendicular to the needle tract on enhanced computed tomography (CT) performed immediately after PMCT. The local effect of the treatment was evaluated by follow-up enhanced CT (6-33 mo). RESULTS: Patients in group I had a significantly larger coagulation area (mean +/- SD = 42.9 mm +/- 8.3), with coagulation times of 5.3 min +/- 1.4, than patients in group 2 (32.6 mm +/- 8.0), with coagulation times of 4.2 min +/- 1.3 (P <.05). Follow-up enhanced CT showed no local enhancement of the tumor, indicating complete necrosis and no local recurrence, except for four tumors. There were no major complications after PMCT except liver abscess that developed after PMCT in one patient with pneumobilia. CONCLUSIONS: PMCT with combined hepatic arterial embolization and temporary hepatic venous flow interruption can coagulate significantly larger volumes of tumor than PMCT with only hepatic arterial embolization.
    LIPPINCOTT WILLIAMS & WILKINS, 2002年02月, JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 13(2) (2), 185 - 191, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 経皮的マイクロターゼ凝固療法および5-FU, Adriamycin, Cisplatin肝動注化学療法が奏効した胃癌術後肝転移の１例
    山本為義, 村上 卓道
    2002年, 癌と化学療法, 29, 2439 - 2432

  • マルチスライスCTによる腹部領域における低濃度製剤の有用性：240mgI/ml製剤によるCT angiography
    河田修治, 村上 卓道
    2002年, 映像情報, 34, 900 - 904

  • Intrahepatic recurrences of hepatocellular carcinoma after hepatectomy - Analysis based on tumor hemodynamics
    M Sakon, H Nagano, S Nakamori, K Dono, K Umeshita, T Murakami, H Nakamura, M Monden
    Hypothesis: Surgical margin, ie, the area of possible local intrahepatic metastasis, is controversial in hepatectomy for hepatocellular carcinoma. Design: The blood drainage area of turner was identified preoperatively by abdominal helical computed tomographic scan under hepatic arteriography and excised as surgical margin. The specimens were pathologically examined on the basis of the corresponding computed tomographic images. Setting: University hospital Patients: From June 2, 1997, to April 24, 2000, 67 patients with hepatocellular carcinoma who underwent curative hepatic resection. Main Outcome Measure: Intrahepatic recurrence. Results: Blood drainage area of tumor could be classified into the following types. The marginal type (drainage into the peritumorous area) was frequent (50 cases) and excised mostly by nonanatomic, limited resection. Portal vein type (drainage into the portal branches) was less common (12 cases) and resected mostly by anatomically systematic hepatectomy. The remaining 5 cases were of the hypovascular type and underwent limited resection. Multiple nodules were frequently found inside the drainage area (4 of 8 cases) and were moderate or poorly differentiated hepatocellular carcinoma, consistent with intrahepatic metastasis. Solitary nodules were mostly outside the drainage area (11 of 12 cases) and contained well-differentiated hepatocellular carcinoma (7 of 10 cases), suggesting multicentric carcinogenesis. Intrahepatic recurrences were commonly found in bilateral or contralateral lobes (17 of 19 cases) and divided into 2 groups with a few (less than or equal to4) and multiple ( E:8) recurrent nodules. Conclusions: Surgical margin varied according to tumor hemodynamics. Tumor recurrences may result not only from multicentric carcinogenesis but also from intrahepatic metastasis via systemic circulation.
    AMER MEDICAL ASSOC, 2002年01月, ARCHIVES OF SURGERY, 137(1) (1), 94 - 99, 英語
    研究論文（学術雑誌）

  • Osakuni Morimoto, Hiroaki Nagano, Masato Sakon, Hidetoshi Eguchi, Atsushi Miyamoto, Motoi Kondo, Isao Arai, Tameyoshi Yamamoto, Keizo Dono, Koji Umeshita, Manabu Takamura, Takamichi Murakami, Shoji Nakamori, Hironobu Nakamura, Morito Monden
    We report the case of a liver abscess associated with microwave coagulation therapy (MCT). A 67-year-old man underwent a pylorus-preserving pancreatoduodenectomy for bile duct cancer in August 1998. In June 1999, abdominal computed tomography (CT) showed three low-density areas in his liver. With a diagnosis of multiple metastatic liver tumors, we applied MCT to each liver tumor. The patient presented with fever after therapy. Abdominal CT showed a hepatic abscess, which was treated by percutaneous transhepatic abscess drainage under ultrasonography. A bacteriological examination of the pus material revealed the presence of Enterococcus faecalis and Candida albicans. Treatment resulted in a rapid resolution of symptoms. Our case indicated that care should be exercised in using MCT for the treatment of liver tumors in patients who have undergone reconstructive surgery of the biliary tract.
    2002年, Surgery today, 32(5) (5), 454 - 7, 英語, 国内誌

  • High dose rate endovascular brachytherapy in aorto-iliac lesion for the prevention of restenosis
    Hideya Yamazaki, Kaname Tomoda, Hiroya Shiomi, Munehiro Maeda, Shuji Kawata, Atsuya Okada, Takamichi Murakami, Hironobu Nakamura, Eiichi Tanaka, Takehiro Inoue, Toshihiko Inoue
    This study examined the applicability of endovascular brachytherapy to larger del arteries such as the abdominal aorta and iliac artery. Endovascular brachytherapy using an Ir-192 HDR source was administered 11 times to nine patients who had undergone percutaneous transluminal angioplasty (PTA) between 1995 and 1999. The follow-up lasted 13 to 55 months after treatment (median, 24 months). Eight of the 11 lesions have been controlled so far. Although one case developed thrombus inside the stent five months later, recanalization was achieved by means of retreatment. One patient who underwent low-dose irradiation (6 Gy) without stent implantation showed restenosis five months after treatment. We used a centering catheter that did not block the blood stream for exact centering of the radiation source in larger vessels such as the abdominal aorta. Although endovascular brachytherapy is a promising and safe procedure, careful follow-up is needed to detect untoward reactions such as thrombosis.
    2002年, Radiation Medicine - Medical Imaging and Radiation Oncology, 20(1) (1), 25 - 32, 英語
    研究論文（学術雑誌）

  • Multi-detector row helical CT angiography of hepatic vessels: Depiction with dual-arterial phase acquisition during single breath hold
    S Takahashi, T Murakami, M Takamura, T Kim, M Hori, Y Narumi, H Nakamura, M Kudo
    PURPOSE: To determine by using multi-detector row computed tomography (CT), in a triphasic hepatic dynamic study, which included single breath-hold dual-arterial phase acquisition, the accuracy and frequency of visualization of the small hepatic arterial and portal venous anatomy with angiographic correlation. MATERIALS AND METHODS: In 62 patients, pre- and postcontrast triphasic helical CT were performed by using a multi-detector row CT scanner, with 2.5-mm detector row collimation, at a pitch of 6. The first and second arterial phases were performed during a single breath hold. One reader, blinded to the results of the angiography, reviewed the first arterial phase images on a cine display to assess hepatic arterial anatomy. Visualization of the portal vein and its branches was assessed by using second arterial and portal venous phase images. RESULTS: Major arterial trunks (celiac, hepatic, superior mesenteric, and left gastric) were depicted in all cases. Visualization of small arteries was as follows: right and left hepatic, 62 (100%) of 62; middle hepatic, 52 (87%) of 60; cystic, 47 (90%) of 52; right gastric, 50 (89%) of 56; and right and left inferior phrenic, 57 (92%) and 55 (89%) of 62 respectively Subsegmental or more peripheral branches of the portal vein were depicted in 83% of cases during the second arterial phase and in 96% during the portal phase. There was no difference in degree of visualization in these two phases. CONCLUSION: Multi-detector row CT angiography was able to depict the hepatic vascular anatomy.
    RADIOLOGICAL SOC NORTH AMERICA, 2002年01月, RADIOLOGY, 222(1) (1), 81 - 88, 英語
    研究論文（学術雑誌）

  • Jun Masumoto, Yoshinobu Sato, Masatoshi Hori, Takamichi Murakami, Takeshi Johkoh, Hironobu Nakamura, Shinichi Tamura
    Springer, 2002年, Medical Image Computing and Computer-Assisted Intervention - MICCAI 2002, 5th International Conference, Tokyo, Japan, September 25-28, 2002, Proceedings, Part II, 493 - 500
    [査読有り]

  • S Takahashi, T Murakami, M Takamura, T Kim, M Hori, Y Narumi, H Nakamura, M Kudo
    PURPOSE: To determine by using multi-detector row computed tomography (CT), in a triphasic hepatic dynamic study, which included single breath-hold dual-arterial phase acquisition, the accuracy and frequency of visualization of the small hepatic arterial and portal venous anatomy with angiographic correlation. MATERIALS AND METHODS: In 62 patients, pre- and postcontrast triphasic helical CT were performed by using a multi-detector row CT scanner, with 2.5-mm detector row collimation, at a pitch of 6. The first and second arterial phases were performed during a single breath hold. One reader, blinded to the results of the angiography, reviewed the first arterial phase images on a cine display to assess hepatic arterial anatomy. Visualization of the portal vein and its branches was assessed by using second arterial and portal venous phase images. RESULTS: Major arterial trunks (celiac, hepatic, superior mesenteric, and left gastric) were depicted in all cases. Visualization of small arteries was as follows: right and left hepatic, 62 (100%) of 62; middle hepatic, 52 (87%) of 60; cystic, 47 (90%) of 52; right gastric, 50 (89%) of 56; and right and left inferior phrenic, 57 (92%) and 55 (89%) of 62 respectively Subsegmental or more peripheral branches of the portal vein were depicted in 83% of cases during the second arterial phase and in 96% during the portal phase. There was no difference in degree of visualization in these two phases. CONCLUSION: Multi-detector row CT angiography was able to depict the hepatic vascular anatomy.
    RADIOLOGICAL SOC NORTH AMERICA, 2002年01月, RADIOLOGY, 222(1) (1), 81 - 88, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Intrahepatic recurrences of hepatocellular carcinoma after hepatectomy - Analysis based on tumor hemodynamics
    M Sakon, H Nagano, S Nakamori, K Dono, K Umeshita, T Murakami, H Nakamura, M Monden
    Hypothesis: Surgical margin, ie, the area of possible local intrahepatic metastasis, is controversial in hepatectomy for hepatocellular carcinoma. Design: The blood drainage area of turner was identified preoperatively by abdominal helical computed tomographic scan under hepatic arteriography and excised as surgical margin. The specimens were pathologically examined on the basis of the corresponding computed tomographic images. Setting: University hospital Patients: From June 2, 1997, to April 24, 2000, 67 patients with hepatocellular carcinoma who underwent curative hepatic resection. Main Outcome Measure: Intrahepatic recurrence. Results: Blood drainage area of tumor could be classified into the following types. The marginal type (drainage into the peritumorous area) was frequent (50 cases) and excised mostly by nonanatomic, limited resection. Portal vein type (drainage into the portal branches) was less common (12 cases) and resected mostly by anatomically systematic hepatectomy. The remaining 5 cases were of the hypovascular type and underwent limited resection. Multiple nodules were frequently found inside the drainage area (4 of 8 cases) and were moderate or poorly differentiated hepatocellular carcinoma, consistent with intrahepatic metastasis. Solitary nodules were mostly outside the drainage area (11 of 12 cases) and contained well-differentiated hepatocellular carcinoma (7 of 10 cases), suggesting multicentric carcinogenesis. Intrahepatic recurrences were commonly found in bilateral or contralateral lobes (17 of 19 cases) and divided into 2 groups with a few (less than or equal to4) and multiple ( E:8) recurrent nodules. Conclusions: Surgical margin varied according to tumor hemodynamics. Tumor recurrences may result not only from multicentric carcinogenesis but also from intrahepatic metastasis via systemic circulation.
    AMER MEDICAL ASSOC, 2002年01月, ARCHIVES OF SURGERY, 137(1) (1), 94 - 99, 英語
    [査読有り]
    研究論文（学術雑誌）

  • High dose rate endovascular brachytherapy in aorto-iliac lesion for the prevention of restenosis
    Hideya Yamazaki, Kaname Tomoda, Hiroya Shiomi, Munehiro Maeda, Shuji Kawata, Atsuya Okada, Takamichi Murakami, Hironobu Nakamura, Eiichi Tanaka, Takehiro Inoue, Toshihiko Inoue
    This study examined the applicability of endovascular brachytherapy to larger del arteries such as the abdominal aorta and iliac artery. Endovascular brachytherapy using an Ir-192 HDR source was administered 11 times to nine patients who had undergone percutaneous transluminal angioplasty (PTA) between 1995 and 1999. The follow-up lasted 13 to 55 months after treatment (median, 24 months). Eight of the 11 lesions have been controlled so far. Although one case developed thrombus inside the stent five months later, recanalization was achieved by means of retreatment. One patient who underwent low-dose irradiation (6 Gy) without stent implantation showed restenosis five months after treatment. We used a centering catheter that did not block the blood stream for exact centering of the radiation source in larger vessels such as the abdominal aorta. Although endovascular brachytherapy is a promising and safe procedure, careful follow-up is needed to detect untoward reactions such as thrombosis.
    1, 2002年, Radiation Medicine - Medical Imaging and Radiation Oncology, 20(1) (1), 25 - 32, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Osakuni Morimoto, Hiroaki Nagano, Masato Sakon, Hidetoshi Eguchi, Atsushi Miyamoto, Motoi Kondo, Isao Arai, Tameyoshi Yamamoto, Keizo Dono, Koji Umeshita, Manabu Takamura, Takamichi Murakami, Shoji Nakamori, Hironobu Nakamura, Morito Monden
    We report the case of a liver abscess associated with microwave coagulation therapy (MCT). A 67-year-old man underwent a pylorus-preserving pancreatoduodenectomy for bile duct cancer in August 1998. In June 1999, abdominal computed tomography (CT) showed three low-density areas in his liver. With a diagnosis of multiple metastatic liver tumors, we applied MCT to each liver tumor. The patient presented with fever after therapy. Abdominal CT showed a hepatic abscess, which was treated by percutaneous transhepatic abscess drainage under ultrasonography. A bacteriological examination of the pus material revealed the presence of Enterococcus faecalis and Candida albicans. Treatment resulted in a rapid resolution of symptoms. Our case indicated that care should be exercised in using MCT for the treatment of liver tumors in patients who have undergone reconstructive surgery of the biliary tract.
    5, 2002年, Surgery today, 32(5) (5), 454 - 7, 英語, 国内誌
    [査読有り]

  • Masatoshi Hori, Takamichi Murakami, Tonsok Kim, Hironobu Nakamura
    Both computed tomography arterial portography (CTAP) and CT hepatic arteriography (CTHA) are CT techniques with angiographic assistance. The detection sensitivity of these techniques is high because marked lesion contrast can be obtained using direct delivery of contrast materials to the liver parenchyma or the tumors. The use of CTAP and CTHA may improve therapeutic results after transarterial embolization therapy for hepatocellular carcinomas because of their high diagnostic accuracy. Findings on CTAP or CTHA can sometimes help characterize the hepatic focal lesions. Thus, CTAP and CTHA are frequently performed as pretreatment examinations, although they are invasive compared to intravenous (IV) contrast-enhanced CT or magnetic resonance imaging. However, there are some potential pitfalls, such as nontumorous perfusion abnormalities. CTAP and CTHA are less effective for evaluation of patients with cirrhosis and portal hypertension. This article presents a current overview of CTAP and CTHA technique for diagnosis of hepatic neoplasms. Copyright 2002, Elsevier Science (USA). All rights reserved.
    W.B. Saunders, 2002年, Techniques in Vascular and Interventional Radiology, 5(3) (3), 164 - 169, 英語
    [査読有り]

  • Usefulness of newly developed interactive multiplanar reconstruction viewer for large amount of image sets by multidetector-row CT: evaluation of invasion to surrounding organs of esophageal carcinoma
    T Johkoh, S Yamamoto, T Murakami, M Hori, O Honda, T Kozuka, M Koyama, M Tsubamoto, S Hamada, Y Narum, H Nakamura
    SPRINGER-VERLAG BERLIN, 2002年, CARS 2002: COMPUTER ASSISTED RADIOLOGY AND SURGERY, PROCEEDINGS, 1025 - 1025, 英語
    [査読有り]
    研究論文（国際会議プロシーディングス）

  • R Kuwatsuru, M Kadoya, K Ohtomo, A Tanimoto, S Hirohashi, T Murakami, Y Tanaka, K Yoshikawa, H Katayama
    RATIONALE AND OBJECTIVES. To compare gadobenate dimeglumine (Gd-BOPTA) with gadopentetate dimeglumine (Gd-DTPA) for magnetic resonance imaging of the liver. METHODS. The contrast agent Gd-BOPTA or Gd-DTPA was administered at a dose of 0.1 mmol/kg to 257 patients suspected of having malignant liver tumors. Dynamic phase images, spin-echo images obtained within 10 minutes of injection, and delayed images obtained 40 to 120 minutes after injection were acquired. All postcontrast images were compared with unenhanced TI-weighted and T2-weighted images obtained immediately before injection. A full safety assessment was performed. RESULTS. The contrast efficacy for dynamic phase imaging was moderately or markedly improved in 90.9% (110/121) and 87.9% (109/124) of patients for Gd-BOPTA and Gd-DTPA, respectively. At 40 to 120 minutes after injection, the corresponding improvements were 21.7% (26/120) and 11.6% (14/121) for spin-echo sequences and 44.5% (53/119) and 19.0% (23/121) for breath-hold gradient-echo sequences, respectively. The differences at 40 to 120 minutes after injection were statistically significant (P < 0.02). Increased information at 40 to 120 minutes after injection compared with information acquired within 10 minutes of injection was available for 24.0% (29/121) of patients with Gd-BOPTA and for 14.5% (18/124) of patients with Gd-DTPA (P < 0.03). Adverse events were seen in 4.7% (6/128) and 1.6% (2/127) of patients receiving Gd-BOPTA and Gd-DTPA, respectively. The difference was not statistically significant. CONCLUSIONS. The efficacy of Gd-BOPTA is equivalent to that of Gd-DTPA for liver imaging during the dynamic phase and superior during the delayed (40-120 minutes) phase of contrast enhancement. Both agents are safe for use in magnetic resonance imaging of the liver.
    LIPPINCOTT WILLIAMS & WILKINS, 2001年11月, INVESTIGATIVE RADIOLOGY, 36(11) (11), 632 - 641, 英語
    研究論文（学術雑誌）

  • Pancreatic mass due to chronic pancreatitis: Correlation of CT and MR imaging features with pathologic findings
    T Kim, T Murakami, M Takamura, M Hori, S Takahashi, S Nakamori, M Sakon, Y Tanji, K Wakasa, H Nakamura
    OBJECTIVE. The purpose of this study was to identify helical CT and MR imaging features of pancreatic masses (focal enlargement) due to chronic pancreatitis and their correlation with pathologic findings. CONCLUSION. When histologic fibrosis is uniformly present through the pancreas in patients with chronic pancreatitis, there is no demarcation of masses due to chronic pancreatitis. When there is a greater degree of histologic fibrosis in the masslike part of the pancreas. the mass is often demarcated from the remaining pancreas, and the enhancement pattern on two-phase helical CT and dynamic gadolinium-enhanced MR imaging mimics that of pancreatic adenocarcinoma.
    AMER ROENTGEN RAY SOC, 2001年08月, AMERICAN JOURNAL OF ROENTGENOLOGY, 177(2) (2), 367 - 371, 英語
    研究論文（学術雑誌）

  • MR cholangiography with volume rendering: Receiver operating characteristic curve analysis in patients with choledocholithiasis
    H Kondo, M Kanematsu, Y Shiratori, K Itoh, T Murakami, M Hori, Yasuda, I, M Matsuo, H Nakamura, H Hoshi, H Moriwaki
    OBJECTIVE. The purpose of our study was to compare observer performances for the diagnosis of choledocholithiasis using MR cholangiography with volume-rendered, maximum-intensity-projection, and thick-section half-Fourier rapid acquisition with relaxation enhancement sequences. MATERIALS AND METHODS. The images from three types of MR cholangiography performed on 43 patients with biliary calculi were retrospectively analyzed. Image review was conducted for two anatomic compartments (upper biliary tract and common bile duct). A total of 86 compartments, including 19 with bile duct calculi, were reviewed by three independent off-site gastrointestinal radiologists. Observer performance was determined by receiver operating characteristic curve analysis, image quality was subjectively judged by three radiologists. RESULTS. Sensitivity was higher with volume-rendered MR cholangiography (58%) than with thick-section (54%, not significant) and maximum-intensity-projection MR cholangiography (47%, p < 0.07). Specificity was higher with volume-rendered MR cholangiography (92%) than with thick-section (86%, p < 0.03) and maximum-intensity-projection MR cholangiography (88%, not significant). Accuracy was higher with volume-rendered MR cholangiography (84%) than with thick-section and maximum-intensity-projection MR cholangiography (79% for both, not significant). Observer performance with volume-rendered MR cholangiography (A(z) = 0.791-0.952) was batter than that with thick-section (A(z) = 0.722-0.834) and maximum-intensity-projection MR cholangiography (A(z) = 0.771-0.87). Image quality was better with maximum-intensity-projection MR cholaniography and thick-section MR cholangiography than with volume-rendered MR cholangiography (p < 0.0001). CONCLUSION. Observer performance with volume-rendered MR cholangiography was better than th at with maximum-intensity-projection and thick-section MR cholangiography for the diagnosis of choledocholithiasis. Volume rendering may be an efficient technique for the reconstruction of MR cholangiography.
    AMER ROENTGEN RAY SOC, 2001年05月, AMERICAN JOURNAL OF ROENTGENOLOGY, 176(5) (5), 1183 - 1189, 英語
    研究論文（学術雑誌）

  • Microwave coagulation therapy with interruption of hepatic blood in- or outflow: An experimental study
    M Takamura, T Murakami, T Shibata, T Ishida, T Niinobu, S Kawata, J Shimizu, T Kim, M Monden, H Nakamura
    PURPOSE: To determine how interruption of hepatic blood in- or outflow affects the coagulation diameter of microwave coagulation therapy (MCT) in the liver. MATERIALS AND METHODS: Laparotomic MCT at 60 W for 1 minute was performed in 11 Landrace pigs. MCT was performed under six different conditions: without occlusion (Group N; in seven lobes of seven pigs); with occlusion of the hepatic artery (Group A; in five lobes of five pigs); with occlusion of the portal vein (Group P;in five lobes of five pigs); with occlusion of the hepatic artery and portal vein (Group AP; in six lobes of six pigs); with occlusion of the hepatic vein (Group V; in five lobes of four pigs); and with occlusion of the hepatic artery and vein (Group AV; in seven lobes of seven pigs). The maximum diameters for each group were compared. RESULTS: The coagulation diameters (mean +/- SD) were 8.5 mm +/- 2.0, 10.0 mm +/- 1.6, 14.3 mm +/- 2.5, 14.4 mm +/- 2.4, 13.0 mm +/- 0.8, and 14.4 mm +/- 1.5 for Groups N, A, P,AP, V, and AV, respectively. The coagulation diameters for groups P, AP, V, and AV were statistically larger than those for groups N and A (P < .05). There was no significant difference between the coagulation diameters of Groups P, AP, V, and AV. CONCLUSION: The coagulation diameter depends mainly on the portal venous flow. In addition of direct interruption of the portal vein, interruption of the hepatic vein can also result in a substantial increase in the coagulation diameter.
    LIPPINCOTT WILLIAMS & WILKINS, 2001年05月, JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 12(5) (5), 619 - 622, 英語
    研究論文（学術雑誌）

  • Hypervascular hepatocellular carcinoma: Detection with double arterial phase multi-detector row helical CT
    T Murakami, T Kim, M Takamura, M Hori, S Takahashi, MP Federle, K Tsuda, K Osuga, S Kawata, H Nakamura, M Kudo
    PURPOSE: To assess whether double arterial phase imaging with multi-detector row helical computed tomography improves detection of hypervascular hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Fifty-one patients with 96 hypervascular HCCs underwent double arterial phase imaging of the entire liver. At measured delay after intravenous administration of 2 mL/kg of contrast medium at a rate of 5 mL/sec, the early and late arterial phase images were obtained serially during a single breath hold with interscan delay of 5.0 seconds. Detector row configuration of 2.5 x 4 mm, pitch of 6, and scanning time of 10.5 seconds for each phase were used. Forty 5-mm-thick reconstruction images were obtained for each phase. Each image set was interpreted separately by three observers, who were unaware of tumor burden in the liver, to detect hypervascular HCC. Sensitivity, positive predictive value, and area below the receiver operating characteristic curve (A(z)) for early and late arterial phases separately and together were calculated. RESULTS: Mean sensitivity and positive predictive value for hypervascular HCC were 54% and 85% for the early arterial phase, 78% and 83% for the late arterial phase, and 86% and 92% for the double arterial phase, respectively. Double arterial phase imaging showed significantly superior sensitivity compared with early or late arterial phase imaging alone for detecting HCC (P < .05). The mean A(z) value for double arterial phase was significantly higher than that for early or late arterial phase imaging alone (P < .05). Double arterial phase imaging showed the lowest number of false-positive lesions. CONCLUSION: Double arterial phase imaging is recommended to improve detection of hypervascular HCCs and reduce false-positive lesions.
    RADIOLOGICAL SOC NORTH AMER, 2001年03月, RADIOLOGY, 218(3) (3), 763 - 767, 英語
    研究論文（学術雑誌）

  • 門脈内腫瘍 (Vp3)を伴う肝細胞癌に対しTAEを施行し3年以上の長期生存を得た1例
    山本為義, 村上 卓道
    2001年, 癌と化学療法, 28, 1718 - 1723

  • マルチスライスCT画像からの肝臓領域自動抽出
    桝本 潤, 村上 卓道
    2001年, 信学論, (9) (9), 2150 - 2161

  • T Murakami, T Kim, M Takamura, J Shimizu, M Hori, K Dono, K Takachi, N Kato, T Miyazawa, M Sakon, M Monden, H Nakamura
    The purpose of this study was to investigate whether regional liver damage could be detected by means of enhanced MR imaging with a superparamagnetic iron oxide (SH U 555A) in an ischemia-reperfusion model of rat liver. Ischemic liver damage was induced in the right lobe by vascular clamping for 0 (sham), 30 (I-30), 60 (I-60), and 90 minutes (I-90), There was no significant difference in relative enhancement (RE) between the ischemic and nonischemic lobes in the sham, I-30 and I-60 groups, while RE of the ischemic lobe was significantly lower than that of its nonischemic counterpart in the I-90 group as seen on SH U 555A enhanced proton density spin echo images (P < 0.05). Histological examination revealed that iron deposits were significantly smaller in the ischemic than the nonischemic lobe in the I-90 group (P < 0.05), although there was no significant difference in the number of Kupffer cells. Our results indicate that severe regional liver damage can be evaluated by MR imaging with SH U 555A.
    KLUWER ACADEMIC/PLENUM PUBL, 2001年01月, DIGESTIVE DISEASES AND SCIENCES, 46(1) (1), 148 - 155, 英語
    研究論文（学術雑誌）

  • M Cruz, T Murakami, K Tsuda, H Kurachi, T Enomoto, T Kim, S Takahashi, H Nakamura
    A myxoid leiomyoma of the uterus is radiologically described. Sonography showed a large mass extending from the renal hilum to the pelvis. Enhanced computed tomography and magnetic resonance imaging findings denoted cystic and myxoid components. Magnetic resonance imaging demonstrated flow voids between the mass and the uterus, indicating likely origin from the uterus. Exploratory laparotomy showed a huge leiomyomatous mass.
    SPRINGER-VERLAG, 2001年01月, ABDOMINAL IMAGING, 26(1) (1), 98 - 101, 英語
    研究論文（学術雑誌）

  • A case of postoperative multiple hepatic metastasis from esophageal cancer successfully treated by surgical resection and hepatic arterial infusion chemotherapy
    H. Nagano, M. Sakon, T. Yasuda, K. Dono, S. Nakamori, M. Yano, K. Umeshita, H. Shiozaki, A. Okada, T. Murakami, H. Nakamura, M. Monden
    A 66-year-old male who underwent radical resection for esophageal cancer (stage IV) was diagnosed with multiple hepatic metastasis 1 year and 3 months after the surgery. He underwent hepatic resection and received systemic chemotherapy (FAP: 5-FU, ADR, CDDP), as the post-operative adjuvant therapy. One year and 3 months later, there was a huge recurrence in the residual liver and hepatic arterial infusion chemotherapy (FAP) was performed. The recurrent lesion disappeared completely after 3 sessions of arterial infusion chemotherapy. The arterial infusion chemotherapy was continued in the outpatient clinic and the recurrent lesion is well controlled. At present, this patient has returned to social life, 2 years and 3 months after the hepatic resection. The utility of hepatic arterial infusion chemotherapy and hepatectomy for postoperative multiple hepatic metastasis from esophageal cancer was shown in the present case.
    2001年, Gan to kagaku ryoho. Cancer & chemotherapy, 28(11) (11), 1628 - 1631, 日本語
    研究論文（学術雑誌）

  • S Takahashi, T Kim, T Murakami, A Okada, M Hori, Y Narumi, H Nakamura
    To assess the ability of gadolinium enhancement to suppress the overlapping vessel signals that diminish the image quality of magnetic resonance cholangiopancreatography (MRCP), we obtained MRCP before and after intravenous injection of gadolinium. Signal intensity ratio of the common bile duct to the main pancreatic duct was significantly improved after the injection of contrast media. The image quality of the postcontrast MRCP was better than that of the precontrast one.
    SPRINGER-VERLAG, 2000年09月, ABDOMINAL IMAGING, 25(5) (5), 511 - 513, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M Matsuo, M Kanematsu, T Murakami, T Kim, M Hori, H Kondo, H Nakamura, H Hoshi
    The purpose of our study was to evaluate the supplementary value of breath-hold fat-suppressed T2-weighted magnetic resonance (MR) imaging with half-Fourier single-shot fast spin-echo (SE) or multishot SE echoplanar (EP) sequences combined with respiratory-triggered fat-suppressed fast SE T2-weighted MR imaging for detection and characterization of focal hepatic lesions. MR images in 42 patients with 82 solid, malignant and 77 nonsolid. benign lesions were analyzed. Image review was conducted on a segment-by-segment basis; in all, 333 liver segments were reviewed separately for solid and nonsolid lesions by three Independent radiologists. For solid lesions. observer performance with receiver-operating-characteristic (ROC) analysis in one radiologist and specificity in another significantly Improved after adding single-shot fast SE Images. For nonsolid lesions, observer performance with ROC analysis in one radiologist and specificity in another significantly improved after adding single-shot fast SE images. Combining breath-hold half-Fourier single-shot fast SE imaging with respiratory-triggered fast SE imaging may be recommended for improved detection and characterization of focal hepatic lesions. (C) 2000 Wiley-Liss, Inc.
    JOHN WILEY & SONS INC, 2000年09月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 12(3) (3), 444 - 452, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Ｘ線CT画像からの肝腫瘤自動抽出の検討
    桝本 潤, 堀 雅敏, 佐藤 嘉伸, 村上 卓道, 上甲 剛, 中村 仁信, 田村 進一
    2000年06月, 信学論 (D-II), 日本語
    [査読有り]
    研究論文（学術雑誌）

  • 木村 拓也, 長谷川 利路, 大植 孝治, 帆足 孝也, 岡田 正, 村上 卓道, 中村 健治
    (一社)日本小児外科学会, 2000年05月, 日本小児外科学会雑誌, 36(3) (3), 568 - 568, 日本語

  • Takashi Shibata, Takamichi Murakami, Norio Ogata
    BACKGROUND. Although percutaneous microwave coagulation is relatively noninvasive therapy for patients with hepatic tumors, coagulation of tumors is sometimes incomplete and local recurrence occurs. The authors hypothesized that the cause of incomplete coagulation was a cooling effect in surrounding hepatic blood flow. To prove this hypothesis and to improve the efficacy of this therapy, they interrupted hepatic blood flow during the treatment and measured the amount of tumor tissue coagulated by microwave. METHODS. The authors first performed an animal experiment on pigs. After laparotomy, the liver of an anesthetized pig was coagulated by microwave with or without interruption of hepatic blood flow the interruption was achieved by squeezing hepatic blood vessels. Next, the authors applied the microwave coagulation percutaneously to 25 human patients with primary or metastatic carcinoma in the liver with or without intraoperative temporary interruption of hepatic blood flow the interruption was achieved by inflating balloon catheters inserted in the hepatic blood vessels through femoral vessels. RESULTS. The greatest dimension of area of normal liver tissue coagulated by microwave with blood flow interruption was significantly (P < 0.001) larger (18.8 ± 1.0 mm, n = 4) than without it (9.8 ± 1.7 mm, n = 4) in the experiment with pigs. In human hepatic tumors, the greatest dimension of the area coagulated by microwave with blood flow interruption was also significantly (P < 0.001) larger (41.1 ± 9.3 mm, n = 14) than without it (26.9 ± 8.5 mm, n = 11). The local recurrence rate of the tumor during a period of 6 months after the treatment was lower (P < 0.05) with blood flow interruption (7%) than without it (45%). CONCLUSIONS. Intraoperative interruption of hepatic blood flow increases the areas of primary and metastatic hepatic tumors coagulated by microwave. It is expected to increase the efficacy of percutaneous microwave coagulation therapy for patients with hepatic tumors.
    2000年01月, Cancer, 88(2) (2), 302 - 311, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 木村 拓也, 長谷川 利路, 大植 孝治, 帆足 孝也, 岡田 正, 村上 卓道, 中村 健治
    特定非営利活動法人 日本小児外科学会, 2000年, 日本小児外科学会雑誌, 36(3) (3), 150 - 150, 日本語

  • Helical CT imaging of gastric cancer: Normal wall appearance and the potential for staging
    K. Kadowaki, T. Murakami, H. Yoshioka, T. Kim, S. Takahashi, K. Tomoda, Y. Narumi, H. Nakamura
    Purpose: To evaluate the CT appearance of the normal gastric wall and the effectiveness of contrast enhanced helical CT for T-staging of gastric cancer. Methods: For the basic experiment, two resected stomachs with gastric cancer were filled with water and examined by helical CT imaging. For the clinical study, 59 consecutive patients with gastric cancer who had received preoperative helical CT examination and had also been operated on were entered in this study. Helical CT images were evaluated independently by three radiologists without knowledge of histological staging results. Results: The basic examination of a histopathological correlation with CT images revealed that the inner layer with high attenuation corresponded to the mucosa and the muscular layer of the mucosa, the middle layer with low attenuation to the submucosal layer consisting of coarse tissues and containing fatty tissues, and the outer layer with slightly high attenuation to the proper muscle with serosa. The clinical study revealed that the rate of correct diagnosis through consensus reading was 66.1%. Conclusion: The entire stomach with a well-stained mucosa can be visualized by contrast enhanced helical CT. However, T-staging of gastric cancer by helical CT did not appear to improve the accuracy of staging.
    2000年, Radiation Medicine - Medical Imaging and Radiation Oncology, 18(1) (1), 47 - 54, 英語
    [査読有り]
    研究論文（学術雑誌）

  • MR imaging of mesenteric hemangioma: A case report
    M. Takamura, T. Murakami, H. Kurachi, T. Kim, T. Enomoto, Y. Narumi, H. Nakamura
    A 62-year-old woman presented with a mobile abdominal palpable mass. She underwent MR examination twice. Because of the mobility of the mass, it was out of the field of view on the first MR examination. The second MR examination detected the mass, which showed heterogeneous signal intensity including low and high intensity on T2-weighted spin echo images. The mass, which was cavernous hemangioma with old hemorrhage, was difficult to differentiate from fibroma or thecoma of the ovary or subserosal leiomyoma of the uterus.
    2000年, Radiation Medicine - Medical Imaging and Radiation Oncology, 18(1) (1), 67 - 69, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Scintigraphic and MR perfusion imaging in preoperative evaluation for lung volume reduction surgery: Pilot study results
    T. Johkoh, N. L. Muller, P. V. Kavanagh, Y. Cartier, J. R. Mayo, N. Tomiyama, T. Murakami, H. Naito, H. Nakamura, H. Moriya
    Purpose: To compare MR perfusion imaging with perfusion scintigraphy in the evaluation of patients with pulmonary emphysema being considered for lung volume reduction surgery. Patients and Methods: Six patients with pulmonary emphysema and two normal individuals were evaluated by MR perfusion imaging, perfusion scintigraphy, and selective bilateral pulmonary angiography. MR images were obtained with an enhanced fast gradient recalled echo with three-dimensional Fourier transformation technique (efgre 3D) (6.3/1.3 flip angle, 30° field of view, 45-48 cm matrix, 256x160). The presence or absence of perfusion defects in each segment was evaluated by two independent observers. Results: Using angiography as the gold standard, the sensitivity, specificity, and accuracy of MR perfusion imaging in detecting focal perfusion abnormalities were 90%, 87%, and 89%, respectively, while those of perfusion scintigraphy were 71%, 76%, and 71%, respectively. The diagnostic accuracy of MR perfusion imaging was significantly higher than that of scintigrapy (p< 0.001, McNemar test). There was good agreement between two observers for MR perfusion imaging (kappa statistic, 0.66) and only moderate agreement for perfusion scintigraphy (kappa statistic, 0.51). Conclusion: MR perfusion imaging is superior to perfusion scintigraphy in the evaluation of pulmonary parenchymal perfusion in patients with pulmonary emphysema.
    2000年, Radiation Medicine - Medical Imaging and Radiation Oncology, 18(5) (5), 277 - 281, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Takuya Kimura, Toshimichi Hasegawa, Takaharu Oue, Takaya Hoashi, Takamichi Murakami, Kenji Nakamura, Akira Okada
    Although transjugular intrahepatic portosystemic shunt (TIPS) is widely accepted in adults, there have been few successful reports in infants. The authors describe a 2-year-old boy with postoperative biliary atresia who underwent TIPS for uncontrollable lower intestinal bleeding and achieved hemostasis. Massive melena developed, which was not controlled by conservative therapy and devascularization. A shunt was created between the right hepatic vein and the right portal vein with a 6- x 50-mm Wallstent. After TIPS, the porto-systemic pressure gradient decreased from 15 to 11 mm Hg, and collaterals markedly reduced. He has not had recurrent bleeding for over 7 months. TIPS may be a technically feasible and effective treatment to control intestinal bleeding in infants. However, further experience and long-term follow-up will be required. Copyright (C) 2000 by W.B. Saunders Company.
    2000年, Journal of Pediatric Surgery, 35(11) (11), 1597 - 1599, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 村上 卓道, 高村 学, 清水 潤三, 中森 正二, 柴田 高, 石田 毅, 左近 賢人, 門田 守人, 中村 仁信
    膵癌の転移性肝腫瘍に対し, バルーンカテーテルおよびSpherexR併用区域肝血流遮断下マイクロ波凝固療法 (MCT) を施行し, 著効した症例を経験した. 75歳, 男性. 根治手術不可の膵癌に対し, 化学療法および放射線療法を施行され, 主腫瘍は縮小したが, 肝左葉外側区域に25mm大, 右葉後下区域に45mm大の転移を認めた. 肝の担癌区域を還流する肝静脈をバルーンカテーテルで閉塞し, 更に同区域に流入する肝動脈を細動脈レベルで一過性に閉塞する微少デンプン粒子 (SpherexR) で塞栓することによって, 担癌区域の肝血流による冷却効果を低下させMCTを行った. 1.6mm径砲弾型深部用電極を用いて, 右葉の腫瘍は60W, 4分間凝固, 左葉の腫瘍は2分凝固で, 腫瘍を完全凝固できた. 術後SpherexRで塞栓した血管はすべて再開通が見られ, また合併症も見られなかった.
    The Japan Society of Hepatology, 1999年11月, 肝臓, 40(11) (11), 626 - 630, 日本語

  • Clinical late phase II trials of MultiHance (R) (Gd-BOPTA) for the magnetic resonance imaging of liver tumors in Japan
    R Kuwatsuru, M Kadoya, K Ohtomo, A Tanimoto, S Hirohashi, T Murakami, Y Tanaka, K Yoshikawa, H Katayama
    Objective: The purpose of the study was to evaluate the safety and efficacy of Gd-BOPTA for liver imaging and to determine the most appropriate clinical dose to administer. Methods: Gd-BOPTA was administered at a dose of 0.05 (group A), 0.1 (group B), or 0.2 (group C) mmol/kg to 201 patients suspected of having malignant liver tumors who had been referred for magnetic resonance imaging. Dynamic phase images (T1-weighted gradient echo sequences obtained during breath-hold), images obtained within 10 min of Gd-BOPTA injection (spin echo images) and delayed images obtained at 40-120 min after Gd-BOPTA injection (T1-weighted spin echo and gradient echo sequences during breath-hold) were acquired. All post-contrast images were compared with pre-contrast images (T1- and T2-weighted sequences) obtained immediately prior to Gd-BOPTA administration. Safety was assessed in terms of the incidence of adverse events. Results: The contrast efficacy for the dynamic study was classified as (+++) in 39.7% (27/68), 55.4% (36/65), and 47.0% (31/66) for groups A, B, and C, respectively. The contrast efficacy within 10 min of the injection was classified as (+++) in 7.6% (5/66); 16.9% (11/65), and 12.5% (8/64) for groups A, B, and C, respectively. The contrast efficacy at 40-120 min post-injection was classified as (+++) in 4.4% (3/68), 21.5% (14/65), and 20.0% (13/65) for groups A, B, and C, respectively with significant differences noted between groups A and B and groups A and C. As regards safety, the overall incidence of adverse reactions was 3.5% (7/199). Conclusion: Gd-BOPTA is a safe and efficacious contrast agent for use in both dynamic phase imaging and delayed (40-120 min) static imaging. A dose of 0.1 mmol/kg Gd-BOPTA appears to be the ideal dose for use in liver imaging in Japan.
    LIPPINCOTT WILLIAMS & WILKINS, 1999年11月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 23, S65 - S74, 英語
    [査読有り]
    研究論文（学術雑誌）

  • T Kim, T Murakami, S Takahashi, M Hori, M Sakon, S Nakamori, K Wakasa, H Nakamura
    We present two cases of ductal adenocarcinoma of the pancreas with intratumoral calcification. The two cases indicate two different etiologies for intratumoral calcification in ductal adenocarcinoma. Thus, the possibility of adenocarcinoma should be considered when a tumor with intratumoral calcification is found, although the incidence of intratumoral calcification in the ductal adenocarcinoma of the pancreas remains rare.
    SPRINGER VERLAG, 1999年11月, ABDOMINAL IMAGING, 24(6) (6), 610 - 613, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Detection of hepatocellular carcinoma: Comparison of low- and high-spatial-resolution dynamic MR images
    M Kanematsu, H Hoshi, T Murakami, K Itoh, M Hori, H Kondo, H Nakamura
    OBJECTIVE, The purpose of our study was to compare the diagnostic performance of low- and high-spatial-resolution gadolinium chelate-enhanced triphasic dynamic gradient-recalled echo (GRE) MR images in the detection of hepatocellular carcinoma. MATERIALS AND METHODS. Triphasic dynamic MR images obtained with low (256 x 128) and high (512 x 224) image matrices in 28 patients with 65 hepatocellular carcinomas (HCCs) were retrospectively analyzed. Image review was conducted on a segment-by-segment basis; a total of 215 liver segments, including 56 segments with tumor burden, were reviewed for the presence of HCC by three independent radiologists. Detectability was evaluated with relative sensitivity, specificity, and receiver operating characteristic (ROC) analysis. Image quality was evaluated with rank order analysis. RESULTS. Relative sensitivity was statistically significantly better with high-spatial-resolution images than with low-spatial-resolution images (p < .005). Relative specificity was statistically significantly better with low-spatial-resolution images than with high-spatial-resolution images (p < .001). Diagnostic accuracy determined by ROC curve analysis was marginally higher with high-spatial-resolution (area under ROC curve [A(z)] = .97) than with low-spatial-resolution (A(z) = .94, p < .09) images. Image quality was statistically significantly better with high-spatial-resolution images (p < .005). CONCLUSION. High-spatial-resolution dynamic CURE images were superior to low-spatial-resolution images in sensitivity of detecting HCC and in image quality. Triphasic dynamic GRE imaging in the screening and follow-up programs of patients with suspected HCC should be performed using high image matrices.
    AMER ROENTGEN RAY SOC, 1999年11月, AMERICAN JOURNAL OF ROENTGENOLOGY, 173(5) (5), 1207 - 1212, 英語
    [査読有り]
    研究論文（学術雑誌）

  • T Obi, T Murakami, M Takatsu, S Kusunoki, M Serizawa, K Mizoguchi, R Koike, Y Nishimura
    A previously reported patient presenting sensory-dominant neuropathy with antiganglioside antibodies, bound preferentially to polysialogangliosides including GD1b, was autopsied. While axonal degeneration was predominant in the sural nerve, many demyelinated fibers were present in the spinal roots. Dorsal roots had undergone significant damage. These pathological findings were well correlated with the electrophysiological results showing decreased F-wave conduction velocities and conduction blocks in motor nerves and decreased or absent sensory action potentials in sensory nerves, with distribution of GD1b in nerve tissues such as dorsal root ganglia and paranodal myelin in the ventral and dorsal roots. (C) 1999 John Wiley & Sons, Inc.
    JOHN WILEY & SONS INC, 1999年10月, MUSCLE & NERVE, 22(10) (10), 1426 - 1431, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Evaluation of gadobenate dimeglumine in hepatocellular carcinoma: Results from phase II and phase III clinical trials in Japan
    A Tanimoto, R Kuwatsuru, M Kadoya, K Ohtomo, S Hirohashi, T Murakami, K Hiramatsu, K Yoshikawa, H Katayama
    To evaluate the clinical efficacy of gadobenate dimeglumine (Gd-BOPTA)-enhanced magnetic resonance imaging for hepatocellular carcinoma (HCC), we reviewed the results of clinical phase II and III trials in Japan. Gd-BOPTA was administered at a dose of 0.1 mmol/kg to 139 patients who were suspected to have HCC. Dynamic phase images (breath-hold T1-weighted gradient echo [GRE)], spin-echo (SE) images obtained within 10 minutes of injection, and delayed breath-hold GRE images obtained 40-120 minutes after injection were evaluated, All post-contrast images were compared with T1- and Ta-weighted pre-contrast images. The contrast efficacy for the dynamic study was classified as (+++) or (++) in 92.1% (128/139), in 43.1% (59/ 137) with SE within 10 minutes of injection, and in 43.2% (60/139) with breath-hold GRE at delayed phase, The increase in lesion-liver contrast-to-noise ratio was best at the arterial phase of dynamic breath-hold GRE. Liver signal-to-noise ratio showed a mean 52.3% increase in delayed phase, Additional information at delayed phase compared with images acquired within 10 minutes of injection (including the dynamic study) was classified as (+++) or (++) in 28.1% (39/139), With regard to safety, the overall incidence of adverse reactions was 5.0% (7/141) of the patients who were suspected to have HCC, all of whom recovered within 12 hours without any sequelae, No clinically important changes were observed in the blood and urine laboratory tests. It was concluded that Gd-BOPTA was well tolerated and effective in both dynamic study and delayed static imaging for the diagnosis of HCC. (C) 1999 Wiley-Liss, Inc.
    JOHN WILEY & SONS INC, 1999年09月, JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 10(3) (3), 450 - 460, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Optimal phases of dynamic CT for detecting hepatocellular carcinoma: evaluation of unenhanced and triple-phase images
    T Kim, T Murakami, S Takahashi, K Tsuda, K Tomoda, Y Narumi, H Oi, M Sakon, H Nakamura
    Background: To determine the optimal phases of dynamic computed tomography (CT) for detecting hepatocellular carcinoma (HCC). Methods: Fifty-two patients with 85 HCC Modules were examined by means of unenhanced and triple-phase CT images of the whole liver. The time for obtaining the arterial-phase images was 25-55 s after intravenous bolus injection of contrast material, the time for obtaining the portal venous-phase images was 65-100 s, and the time for obtaining late-phase images was 145 s to 4 min. Detectability of the HCC nodules for all phases was statistically compared. Results: The detection rates for the arterial- and late-phase images were significantly higher than for the unenhanced and portal venous-phase images (p < 0.01). The combination of arterial- and late-phase images showed the same number of HCC nodules in the same number of patients as did the combination of unenhanced and triple-phase images. Conclusion: The combination of the arterial- and late-phase imagings was best for detecting HCC nodules.
    SPRINGER VERLAG, 1999年09月, ABDOMINAL IMAGING, 24(5) (5), 473 - 480, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Diffusion-weighted single-shot echoplanar MR imaging for liver disease
    T Kim, T Murakami, S Takahashi, M Hori, K Tsuda, H Nakamura
    OBJECTIVE. The aims of this study were to determine apparent diffusion coefficients (ADCs) of the abdominal organs and liver lesions, to determine the effect of the magnitude of b values on the ADCs, and to determine whether measured ADCs of liver tumors help differentiate benign from malignant lesions. SUBJECTS AND METHODS. Six healthy volunteers and 126 patients were examined with diffusion-weighted single shot echoplanar imaging using multiple b values (maximum, 846 sec/mm(2)). The ADCs of the liver, spleen, kidney, 49 malignant liver lesions (33 hepatocellular carcinomas, 15 metastatic liver tumors, and one cholangiocellular carcinoma), and 30 benign lesions (17 cysts, 12 hemangiomas, and one angiomyolipoma) were calculated. RESULTS. The ADCs of the abdominal organs and liver lesions showed smaller values when calculated with the greater maximum b values. The ADCs of the benign lesions calculated with all the b values of less than 850 sec/mm(2) (2.49 +/- 1.39 x 10(-3) mm(2)/sec) were significantly (p = .0024) greater than those of the malignant lesions (1.01 +/- 0.38 x 10(-3) mm(2)/sec). When the maximum b value is 846 sec/mm(2), use of a threshold ADC of 1.6 x 10(-3) mm(2)/sec would result in a sensitivity of 98% and a specificity of 80% for differentiation of malignant liver lesions from benign lesions. CONCLUSION. Measurement of ADC has good potential for characterizing liver lesions, but the calculated ADCs could be affected by the magnitude of the maximum b value.
    AMER ROENTGEN RAY SOC, 1999年08月, AMERICAN JOURNAL OF ROENTGENOLOGY, 173(2) (2), 393 - 398, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Evaluation of regional liver function by gadolinium-EOB-DTPA-enhanced MR imaging
    J Shimizu, K Dono, M Gotoh, Y Hasuike, T Kim, T Murakami, M Sakon, K Umeshita, H Nagano, S Nakamori, N Kato, T Miyazawa, H Nakamura, M Monden
    We evaluated the role of magnetic resonance (MR) imaging with gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA), in estimating regional liver function in a rat ischemia-reperfusion model. Ischemic liver damage was induced in the right lobe by vascular clamping for 0 (sham), 30 (I-30), 60 (I-60), and 90 min (I-90 group). The ischemic lobes in the I-60 and I-90 groups was clearly visualized as a high intensity area in the T1 images at late phase of Gd-EOB-DTPA enhancement, Moreover, the T1/2 of signal intensity in ischemic lobes significantly correlated with the duration of vascular clamping. We also observed significant correlation between T1/2 and ATP concentration in the liver tissue (r = -0.719, P = 0.04). Our results indicate that MR imaging with Gd-EOB-DTPA is useful for evaluation of regional liver function in rats.
    KLUWER ACADEMIC/PLENUM PUBL, 1999年07月, DIGESTIVE DISEASES AND SCIENCES, 44(7) (7), 1330 - 1337, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Pancreatic CT imaging: Effects of different injection rates and doses of contrast material
    T Kim, T Murakami, S Takahashi, A Okada, M Hori, Y Narumi, H Nakamura
    PURPOSE: To assess the effects of the intravenous injection rate and dose of contrast material on pancreatic computed tomography (CT). MATERIALS AND METHODS: A total of 126 patients were divided at random into four groups with different injection rates and doses. Groups 1 and 2 underwent injection of 2 mt per kilogram of body weight of 300 mg of iodine per milliliter of contrast material, and groups 3 and 4 underwent injection of 1.5 mL/kg. The injection rate was 5 mL/sec for groups 1 and 3 and 3 mL/sec for groups 2 and 4. Single-level serial CT scanning was performed at the level of the pancreatic head, and the pancreatic enhancement value was calculated. RESULTS: The maximum pancreatic enhancement value was 99 HU +/- 18 (mean +/- SD) for group 1, 90 HU +/- 18 for group 2, 86 HU +/- 15 for group 3, and 74 HU +/- 13 for group 4. There were significant differences in the maximum pancreatic enhancement value between groups 1 and 2 (P =.045), between groups 3 and 4 (P =.001), between groups 1 and 3 (P =.016), and between groups 2 and 4 (P =.001). CONCLUSION: Both a higher dose and a faster injection rate increased the maximum pancreatic enhancement value.
    RADIOLOGICAL SOC NORTH AMER, 1999年07月, RADIOLOGY, 212(1) (1), 219 - 225, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M Kanematsu, H Hoshi, T Murakami, K Itoh, M Hori, Y Inaba, H Kondo, R Yokoyama, H Nakamura
    The purpose of our study was to compare the diagnostic accuracy of fat-suppressed T2-weighted magnetic resonance (MR) images obtained with conventional spin-echo (SE), respiratory-triggered fast SE, and breath-hold multishot SE echoplanar (EP) sequences for the detection of hepatocellular carcinoma and metastases. Images obtained with the three sequences in 17 patients (15 with cirrhosis) with 31 hepatocellular carcinomas and 14 patients with 45 metastases were retrospectively analyzed, Image review was conducted on a segment-by-segment basis; in all, 248 liver segments were reviewed separately and independently for detection of solid, malignant lesions. Diagnostic accuracy was evaluated with receiver-operating-characteristic (ROC) curve analysis, Diagnostic accuracy for hepatocellular carcinoma as determined by ROC curve analysis was better by a statistically significant amount for conventional SE (Az = 0.95) images when compared with respiratory-triggered fast SE (Az = 0.83, P < 0.05) and breath-hold multishot SE EP (Az = 0.80, P < 0.05) images, Conventional SE MR sequences should not be replaced with respiratory-triggered fast SE or breath-hold multishot SE EP sequences for T2-weighted MR imaging of patients with hepatocellular carcinoma in cirrhosis, unless sufficient contrast-enhanced dynamic MR imaging Is subsequently performed. J. Magn. Reson. Imaging 1999; 10:25-32, 1999. (C) 1999 Wiley-Liss, Inc.
    JOHN WILEY & SONS INC, 1999年07月, JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 10(1) (1), 25 - 32, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Focal hepatic lesion detection: Comparison of four fat-suppressed T2-weighted MR imaging pulse sequences
    M Kanematsu, H Hoshi, K Itoh, T Murakami, M Hori, H Kondo, R Yokoyama, H Nakamura
    PURPOSE: To evaluate fat-suppressed T2-weighted magnetic resonance (MR) imaging with conventional spin-echo (SE), breath-hold fast SE, respiratory-triggered fast SE, and breath-hold multishot SE echo-planar sequences for the detection of focal hepatic lesions. MATERIALS AND METHODS: Fat-suppressed T2-weighted MR images obtained with the four sequences in 55 patients with 81 solid and 129 nonsolid lesions were retrospectively analyzed. Image review was conducted on a serment-by-segment basis; a total of 440 liver segments were reviewed separately for solid and nonsolid lesions by three independent radiologists. Diagnostic accuracy was evaluated with receiver operating characteristic analysis. RESULTS: The mean lesion-to-liver contrast-to-noise ratio was highest on the multishot SE echo-planar images of both solid and nonsolid lesions. Fat-suppressed respiratory-triggered fast SE images had significantly better (P < .05) or comparative detectability of both solid and nonsolid lesions compared with the other types of images. Image quality was best on the respiratory-triggered fast SE images. CONCLUSION: Fat-suppressed respiratory-triggered fast SE imaging should replace fat-suppressed conventional SE imaging as a standard T2-weighted imaging examination in the detection of focal hepatic lesions.
    RADIOLOGICAL SOC NORTH AMER, 1999年05月, RADIOLOGY, 211(2) (2), 363 - 371, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 時間変化情報を用いたマルチスライスCT画像からの肝臓領域の自動抽出
    桝本 潤, 佐藤 嘉伸, 堀 雅敏, 村上 卓道, 上甲 剛, 中村 仁信, 田村 進一
    1999年05月, 信学技報, 99(427) (427), 51 - 58, 日本語
    [査読有り]
    研究論文（学術雑誌）

  • T Murakami, T Kim, T Sugiura, M Hori, M Takamura, K Wakasa, H Nakamura
    LIPPINCOTT WILLIAMS & WILKINS, 1999年03月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 23(2) (2), 320 - 322, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 柴田 高, 新居延 高宏, 稲田 正己, 石田 毅, 井上 豊, 村上 卓道
    肝動脈塞栓化学療法施行後, 局所再発肝細胞癌に対して, 肝動脈肝静脈バルーン阻血にて担癌葉の肝血流を低下させ, 経皮的にマイクロ波電極を腫瘍に刺入, 1回のマイクロ波凝固治療により腫瘍および周辺部非癌組織を広範囲に凝固し得た症例を経験した. 症例は64歳C型肝炎加療中肝S6に3cm大の肝細胞癌を認め, 初回治療として肝動脈塞栓化学療法を施行したが6カ月後リピオドールの欠損部に2cm大の局所再発を認め本治療を施行した. 治療後の造影CTおよび造影MRIにて腫瘍を含め最大5cm径の球状のマイクロ波凝固が可能であった. 術後2日間の発熱を認めたのみで術後疼痛の訴えは認めなかった. 血液検査では術翌日GOT, GPTの軽度上昇を認めたが術後5日目に低下を確認したため術後6日目に退院した. 術後12日目の造影CTでも広範囲凝固を確認し, 腫瘍マーカーも正常化した.
    The Japan Society of Hepatology, 1999年01月, 肝臓, 40(1) (1), 42 - 46, 日本語

  • A case of fallopian tube carcinoma: Successful preoperative diagnosis with MR imaging
    H. Kurachi, T. Maeda, T. Murakami, K. Tsuda, Y. Narumi, H. Nakamura, A. Miyake, Y. Murata
    We report a case of fallopian tube carcinoma, successfully diagnosed preoperatively. The patient was a 64-year-old woman. Transvaginal sonography and computed tomography showed a cystic and solid tumor on the left side of the uterus, suggesting ovarian cancer. The tumor was, however, suspected to be a fallopian tube carcinoma on MR imaging. MR images showed a solid mass surrounded by a tube-shaped cystic part. At surgery, a solid and cystic tumor was found in the left fallopian tube. MR imaging may be useful to assist in the diagnosis of fallopian tube carcinoma.
    1999年, Radiation Medicine - Medical Imaging and Radiation Oncology, 17(1) (1), 63 - 66, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M. Kanematsu, H. Hoshi, T. Yamada, T. Murakami, T. Kim, M. Kato, R. Yokoyama, H. Nakamura
    Purpose: The purpose of this study was to assess the imaging findings of pathologically-proved small hepatic nodules 2 cm in size or smaller detected with ultrasonography in cirrhotic patients with suspected hepatocellular carcinoma (HCC). Materials and Methods: We evaluated sonographically detected 32 small hepatic nodules which were pathologically confirmed in 23 consecutive cirrhotic patients who were suspected of having HCC. Twenty-six lesions were confirmed with ultrasonographically-guided aspiration needle- core biopsy, and six with definitive surgery. Ultrasonographic examination records were retrospectively reviewed. CT, and MR images obtained with various imaging techniques were retrospectively reviewed by two radiologists in a blind fashion. Results: The 32 hepatic nodules were comprised of seven focal fatty changes, two large regenerative nodules, three low-grade dysplastic nodules, five high-grade dysplastic nodules, and fifteen HCCs. Ultrasonography showed various echogenicity for the hepatic nodules. The signal-intensity characteristics with T1-weighted spin-echo, in-phase gradient-recalled-echo, and dynamic MR imagings may be useful in distinguishing HCC from nonHCC nodules. Conclusions: Nearly half of small hepatic nodules detected with ultrasonography were nonHCC nodules. Ultrasonographic findings may not be reliable in characterizing small hepatic nodules in cirrhosis. CT and MR imaging obtained with the various techniques are still insensitive to these hepatic nodules.
    1999年01月, Abdominal Imaging, 24(1) (1), 47 - 55, 英語
    [査読有り]
    研究論文（学術雑誌）

  • MR imaging of non-squamous vaginal tumors
    K Tsuda, T Murakami, H Kurachi, Y Narumi, T Kim, S Takahashi, K Tomoda, H Ohi, Y Murata, H Nakamura
    We reviewed the MR images and pathologic findings of five cases of primary vaginal neoplasms of non-squamous origin. Histologic types consisted one case each of adenocarcinoma, adenosarcoma, melanoma, lymphoma, and neurilemoma. Magnetic resonance imaging was found useful for evaluating the type and the extension of vaginal tumors.
    SPRINGER VERLAG, 1999年, EUROPEAN RADIOLOGY, 9(6) (6), 1214 - 1218, 英語
    [査読有り]
    研究論文（学術雑誌）

  • MRI of cervical adenocarcinoma with cystic components
    M Takamura, T Murakami, H Kurachi, Y Narumi, K Tsuda, T Enomoto, Y Murata, H Nakamura
    We encountered two cases of endocervical well-differentiated adenocarcinoma with cystic components. Magnetic resonance findings of the first case showed cystic lesion with enhanced mural nodule in the uterine cervix. The second case showed multicystic lesion in the uterine cervix. The cystic walls were thickening in the postcontrast T-weighted image. The cervical adenocarcinoma with cystic components should be added to one of differential diagnosis of the uterine cervical cystic lesion. (C) Elsevier Science Inc., 1999.
    ELSEVIER SCIENCE INC, 1999年01月, CLINICAL IMAGING, 23(1) (1), 40 - 43, 英語
    [査読有り]
    研究論文（学術雑誌）

  • MR imaging patterns of gadolinium retention within liver neoplasms
    MS Peterson, T Murakami, RL Baron
    Background: To determine the spectrum of appearances of gadolinium retention within cholangiocarcinoma (CCA) and other liver neoplasms. Methods: Two hundred ten patients underwent hepatic magnetic resonance imaging (MRI) at 1.5 T with precontrast T1- and T2-weighted spin-echo (SE) images and delayed Gd-DTPA- or gadoteridol-(0.1 mmol/kg) enhanced T1-weighted SE images. Postcontrast images were evaluated for lesions suspicious for tumors, and lesion signal intensity was characterized as homogeneously or heterogeneously hypo-, iso-, mildly hyper-, or markedly hyperintense to liver. Data from 94 patients with benign or malignant neoplasms are presented. Results: Imaging demonstrated 237 malignant neoplasms (121 hepatocellular carcinoma [HCC], 26 CCA, 17 colon carcinoma metastases, 73 other tumors) and 28 benign neoplasms (22 hemangioma, six focal nodular hyperplasia [FNH]). One hundred forty malignant lesions appeared as homogeneous postcontrast (29 hypointense, 75 isointense, 17 mildly hyperintense, 19 markedly hyperintense) and 97 as heterogeneous (15 isointense, 50 mildly hyperintense, 32 markedly hyperintense). Malignant lesions showing homogeneous, mildly or markedly hyperintense signal intensity postcontrast included 10 CCA, seven HCC, six epithelioid hemangioendothelioma, eight neuroendocrine tumor metastases, three adenocarcinoma metastases of unknown origin, and one breast carcinoma metastasis. Hemangiomas appeared as homogeneous postcontrast in 19 lesions (six isointense, one mildly hyperintense, 12 markedly hyperintense) and as heterogeneous in three lesions (markedly hyperintense). FNH appeared as homogeneous postcontrast in one lesion (isointense) and as heterogeneous in five lesions tone isointense, four mildly hyperintense). Conclusion: Homogeneous gadolinium retention on delayed postcontrast images of malignant hepatic neoplasms is seen in a high percentage of CCA lesions and less commonly with other neoplasms.
    SPRINGER VERLAG, 1998年11月, ABDOMINAL IMAGING, 23(6) (6), 592 - 599, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M Hori, T Murakami, T Kim, S Takahashi, H Oi, K Tomoda, Y Narumi, H Nakamura
    Purpose: The purpose of our work was to determine the usefulness of double-phase helical CT during arterial portography (CTAP) for the detection of hypervascular hepatocellular carcinoma (HCC). Method: Eighty-four patients with 176 hypervascular HCC nodules underwent double-phase CTAP. Hypervascular HCCs were diagnosed by iodized oil CT after transcatheter arterial chemoembolization (TACE). The first-phase images were obtained 30 s after the initiation of injection of a nonionic iodinated contrast medium into the superior mesenteric artery or splenic artery, and the second-phase images were obtained after 70 s. These images were interpreted separately for detection of HCC. Results: The double-phase CTAP detected two nodules and six nodules that were missed by the first- and second-phase images, respectively. The sensitivity for hyper vascular HCC nodules was 89% for the first phase, 91% for the second phase, and 93% for the first phase and second phase combined. The double-phase CTAP showed significantly superior sensitivity to the first-phase CTAP for detecting HCC nodules (p < 0.05). However, there was no statistically significant difference between the sensitivities of the double-phase CTAP and the second-phase CTAP. The positive predictive Values of the double-phase images were inferior to those of either the first-phase or the second-phase images alone. Conclusion: Double-phase helical CTAP was found to be no better than second-phase CTAP alone for the detection of hypervascular HCC nodules.
    LIPPINCOTT WILLIAMS & WILKINS, 1998年11月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 22(6) (6), 861 - 867, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 柴田 高, 新居延 高宏, 村上 卓道, 石田 毅
    The Japan Society of Hepatology, 1998年05月, 肝臓, 39(5) (5), 356 - 357, 日本語

  • Experimental hepatic dysfunction: Evaluation by NMR imaging with Gd-EOB-DTPA
    T Murakami, TS Kim, M Gotoh, Y Hasuike, N Kato, T Miyazawa, M Monden, H Nakamura
    ASSOC UNIV RADIOLOGISTS, 1998年04月, ACADEMIC RADIOLOGY, 5, S80 - S82, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Gd-DTPA enhanced multi-shot echo-planar MRI: 転移性肝腫瘍と肝実質のコントラストの向上
    金 東石, 村上 卓道, 高橋 哲, 岡田 篤哉, 堀 雅敏, 宮原 伸浩, 友田 要, 鳴海 善文, 大井 博道, 中村 仁信
    1998年04月, 日本医放会誌, 58(5) (5), 235 - 237, 日本語
    [査読有り]
    研究論文（学術雑誌）

  • Helical CT angiography of living renal donors: Comparison with 3D Fourier transformation phase contrast MRA
    K Tsuda, T Murakami, T Kim, Y Narumi, S Takahashi, K Tomoda, S Takahara, A Okuyama, H Oi, H Nakamura
    Purpose: The purpose of this study was to determine whether helical CT angiography (CTA) or MR angiography (MRA) is the optimal method to use as a preoperative examination for anatomic arterial assessment of Living renal donors. Method: Eighteen candidates to be renal donors underwent helical CTA, 3D Fourier transformation phase contrast (3D-FT-PC) MRA, and digital subtraction angiography (DSA). The CTA and MRA were interpreted separately by three readers independently, and these results were correlated with the findings of DSA. Results: DSA showed nine accessory renal arteries and 10 prehilar branches. CTA revealed seven or eight accessory renal arteries. MRA showed six or seven accessory arteries. Of 10 prehilar branches, 7-9 branches were detected with CTA and 5-8 branches with MRA. Conclusion: Helical CTA is superior to 3D-FT-PC MRA for evaluating the arterial anatomy of living renal donors.
    LIPPINCOTT WILLIAMS & WILKINS, 1998年03月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 22(2) (2), 186 - 193, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Sensitivity in detection of hypervascular hepatocellular carcinoma by helical CT with intra-arterial injection of contrast medium, and by helical CT and MR imaging with intravenous injection of contrast medium
    M Hori, T Murakami, H Oi, T Kim, S Takahashi, M Matsushita, K Tomoda, Y Narumi, K Kadowaki, H Nakamura
    Purpose: To determine the effectiveness of i.a, contrast-enhanced helical CT and of i.v. contrast-enhanced helical CT and MR imaging, in detecting hypervascular hepatocellular carcinoma (HCC). Material and Methods: Fifty patients with 125 hypervascular HCC nodules underwent helical CT both during arterial portography (CTAP) and during hepatic arteriography (CTHA). Helical CT and MR imaging of the entire liver with i.v, administration of contrast medium were also performed. Helical CT images were obtained at 30-33 s (arterial-phase CT) and at 5 min (equilibrium-phase CT) after the initiation of an i.v. bolus injection of contrast medium. After T1- and T2-weighted spin-echo MR imaging, gradient-echo images during breath-holding were obtained prior to and 20 s, 1 min, and 2 min after the bolus administration of 0.1 mmol/kg of gadopentetate dimeglumine (dynamic MR). The sensitivity and positive predictive value of the various techniques were evaluated and compared. Results. In terms of sensitivity for hypervascular HCC nodules of less than 1 cm in diameter, CTAP (90%) and CTHA (88%) were significantly superior to dynamic MR imaging (44%), arterial-phase CT (39%), spin-echo MR imaging (20%), and equilibrium-phase CT (7%) (p<0.001). However, there was no significant difference in the techniques with regard to the detection of lesions equal to or more than 2 cm in diameter. Conclusion: For detecting small hypervascular HCCs, helical CT with i.a. contrast enhancement is superior to helical CT and MR imaging with i.v. enhancement.
    MUNKSGAARD INT PUBL LTD, 1998年03月, ACTA RADIOLOGICA, 39(2) (2), 144 - 151, 英語
    [査読有り]
    研究論文（学術雑誌）

  • MRI appearance of ruptured corpus luteum
    S. Takahashi, T. Murakami, Y. Narumi, H. Kurachi, K. Tsuda, T. Kim, K. Tomoda, H. Nakamura, Y. Murata
    A 20-year-old woman was admitted complaining of lower abdominal pain. Transabdominal ultrasound revealed a fluid collection in the pouch of Douglas and an irregularly shaped ovary with cystic lesions. Malignant cystic mass of the right ovary was highly suspected from the ultrasound findings. Transvaginal peritoneal centesis yielded a bloody fluid, but the pregnancy test was negative. On the third day of admission, menstruation began. MR examination performed four days after the initial onset of pain showed a subacute hematoma just adjacent to the right ovary, and segmental interruption of the right ovarian cortex. Based on these MR findings and the patient's history, subacute hemorrhage from the right ovarian corpus luteum was suspected, and this was confirmed with surgical exploration.
    1998年, Radiation Medicine - Medical Imaging and Radiation Oncology, 16(6) (6), 487 - 489, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Microwave Hepatic Tumor Coagulation Therapy during Stoppage of Hepatic Blood Flow Using Balloon Catheters
    Takamichi Murakami, Takashi Shibata, Takeshi Ishida, Tadayuki Satoh, Hironobu Nakamura
    The usefulness of microwave hepatic tumor coagulation therapy (MTC) with stoppage of hepatic blood flow using a balloon catheter was assessed. By placing a 5-French balloon catheter in a hepatic artery and 6-French balloon catheter in a hepatic vein, hepatic arterial and portal venous flow of the liver segment including the tumor was interrupted. The effects of balloon occlusion were evaluated by CT during arterial portography. MTC with stoppage of hepatic flow was performed for two patients with metastatic liver tumor 2cm in diameter. Enhanced CT obtained after MTC showed no enhancement of the tumor, indicating complete necrosis. There were no complications and the two patients were discharged within 4 days after MTC. MTC with stoppage of hepatic blood flow is effective for treatment of hepatic metastatic tumor.
    1998年, Nippon Acta Radiologica, 58(7) (7), 369 - 371, 日本語
    [査読有り]
    研究論文（学術雑誌）

  • Spectrally selected efgre3d による全肝3D-Dynamic studyの有用性
    高橋 哲, 金 東石, 村上 卓道, 堀 雅敏, 岡田 篤哉, 中田 早紀, 津田 恭, 鳴海 善文, 友田 要, 大井 博道, 中村 仁信
    Three-dimensional gadolinium-enhanced dynamic MRI of whole liver using the spectrally selected enhanced fast gradient recall sequence (spec IR-efgre3d) was performed in five patients with HCC. Ten HCC nodules were confirmed by CTA, CTAP and Lipiodol CT, and all of them were detected with dynamic MRI. MIP images reconstructed from 3D gadolinium-enhanced dynamic MR studies clearly showed the main portal vein and its branches in all cases. Portal vein thrombosis was also demonstrated with the MIP images.
    1998年, 日本医放会誌, 58(3) (3), 99 - 101, 日本語
    [査読有り]
    研究論文（学術雑誌）

  • CT arterial portography and CT arteriography with a triple-lumen balloon catheter
    T Murakami, H Oi, M Hori, T Kim, S Takahashi, M Matsushita, Y Narumi, H Nakamura
    Purpose: To evaluate the usefulness of the triple-lumen balloon catheter in the serial performance of CT arterial portography (CT-AP) and CT arteriography (CT-A). Material and Methods: A combined CT-AP and CT-A examination of 58 patients was carried out in which a cobra-type triple-lumen balloon catheter was used. CT-AP was performed by injecting contrast medium either into the splenic artery through a side-hole in the catheter proximal to the balloon inflated in the common hepatic artery, or into the superior mesenteric artery through an end-hole in the catheter. Then CT-A was serially performed by delivering contrast medium either to the common hepatic artery or the proper hepatic artery from the end-hole, or to the accessory right hepatic artery through a side-hole proximal to the inflated balloon. Results: Sufficient CT-APs were obtained in 53 of the 58 patients (91%), CT-A in 42 (72%), and both in 42 (72%). Incomplete CT-AP was due to technical failure or anatomical anomaly, as was incomplete CT-A. No complications were seen. Conclusion: The triple-lumen balloon catheter technique is useful and convenient in the serial performance of CT-AP and CT-A.
    MUNKSGAARD INT PUBL LTD, 1997年07月, ACTA RADIOLOGICA, 38(4) (4), 553 - 557, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Superparamagnetic iron oxide enhanced magnetic resonance imaging of rat liver with hepatocellular carcinoma and benign hyperplastic nodule
    T Ishida, T Murakami, N Kato, M Takahashi, T Miyazawa, K Tsuda, K Tomoda, Y Narumi, H Nakamura
    RATIONALE AND OBJECTIVES. The authors assess the potential of a new superparamagnetic iron oxide (SPIO) in grading hepatocellular carcinoma (HCC) histologically and in differentiating HCC from benign hyperplastic nodule (HPN). METHODS. Nine Wistar rats (with poorly to moderately differentiated HCC, well-differentiated HCC, and HPN) received drinking water containing N-nitrosomorpholine, and were examined by magnetic resonance imaging (4.7 tesla). Spin-echo images (repetition time/echo time, 600/24.5 mseconds) were obtained before and 15 minutes after intravenous administration of 10 mu mol Fe/kg of SH U 555A. RESULTS. poorly to moderately differentiated and well-differentiated HCC showed no significant change in signal-to-noise ratio (SNR) 15 minutes after contrast, whereas HPN showed a significant decrease in SNR. The contrast-to-noise ratio (CNR) between each kind of tumor and adjacent liver parenchyma showed a significant increase at 15 minutes after contrast. CONCLUSIONS. The SPIO discussed in this article may help to differentiate HCC from HPN, but it remains difficult to grade hepatocellular carcinoma histologically.
    LIPPINCOTT-RAVEN PUBL, 1997年05月, INVESTIGATIVE RADIOLOGY, 32(5) (5), 282 - 287, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hepatocellular carcinoma patients showing long-term complete responses to chemoembolization
    T Hashimoto, H Nakamura, K Tomoda, T Murakami, K Nakanishi, K Tsuda, T Ishida, T Kim, Y Narumi
    W B SAUNDERS CO, 1997年04月, SEMINARS IN ONCOLOGY, 24(2) (2), 26 - 28, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Overestimation ratio of hepatic lesion size on spiral CT arterial portography: An indicator of malignancy
    M. Kanematsu, H. Hoshi, T. Imaeda, T. Murakami, T. Yamada, Y. Nishigaki, Y. Nandate, R. Yokoyama, H. Nakamura
    Purpose: To assess the reliability of the size-overestimation ratio obtained from spiral CT arterial portography (CTAP) and spiral equilibrium- phase CT (EPCT) in distinguishing malignant focal hepatic lesions from benign ones. Methods: The CTAP images and EPCT images obtained five minutes after CTAP in 39 patients with focal hepatic lesions were retrospectively analyzed. Fifty-eight lesions (hepatocellular carcinoma [HCC], 33 metastasis, 10 liver cyst, 10 cavernous hemangioma, 2 adenomatous hyperplasia [AH], 2 focal nodular hyperplasia [FNH], 1) had their sizes measured on CTAP and EPCT images using the calipers on the CT console. Results: The size-overestimation ratios (CTAP/EPCT) were 1.24 ± 0.15 in HCC, 1.28 ± 0.26 in metastasis, 1.02 ± 0.23 in liver cyst, 0.98 ± 0.34 in cavernous hemangioma, 0.94 ± 0.39 in AH, and 1.00 in FNH. Mean size-overestimation ratios for benign- and malignant-lesion groups were 1.00 ± 0.37 and 1.25 ± 0.18, respectively (p < 0.0001). When a cutoff level was set at 1.05, sensitivity and specificity for malignancy were 91% and 93%, respectively. Conclusions: In comparison with EPCT, CTAP significantly overestimates the size of malignant hepatic tumors. This phenomenon may be an indicator of hepatic malignancy.
    1997年, Radiation Medicine - Medical Imaging and Radiation Oncology, 15(5) (5), 267 - 272, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Trial of a Detachable Y-shaped Tube with Two Valves for Serial Examinations of CT Arterial Portography and CT Hepatic Arteriography
    Takamichi Murakami, Kaname Tomoda, Tsutomu Sakamoto, Tonsok Kim, Kyo Tsuda, Satoru Takahashi, Atsuya Okada, Takashi Sugiura, Yoshifumi Narumi, Hironobu Nakamura
    In five patients with hepatocellular carcinoma, CT arterial portography (CTAP) and CT hepatic arteriography (CTHA) were performed serially by using a newly developed detachable Y-shaped tube with two valves that could be attached to a conventional angiographic sheath. Two catheters could be inserted into the conventional angiographic sheath without blood backflow by using the Y-shaped tube. One catheter could be easily and safety placed on the common or proper hepatic artery, and the other on the superior mesenteric artery. This detachable Y-shaped tube with two valves could make it easy to perform serial CTAP and CTHA examinations.
    1997年, Nippon Acta Radiologica, 57(7) (7), 430 - 432, 日本語
    [査読有り]
    研究論文（学術雑誌）

  • A case of hepatocellular carcinoma detected by dynamic CT and MRI but not digital subtraction angiography
    Atsushi Omae, Kazuhiro Katayama, Takuya Miyagi, Norihiro Enomoto, Akihiko Ito, Hirotaka Nagai, Yoshiki Ito, Hideki Hagiwara, Kiyoshi Mochizuki, Akinori Kasahara, Takamichi Murakami, Kaname Tomoda, Hironobu Nakamura, Norio Hayashi
    1997年01月, Japanese Journal of Gastroenterology, 94(1) (1), 56 - 61, 日本語
    [査読有り]
    研究論文（学術雑誌）

  • Combined hepatocellular and cholangiocellular carcinoma
    T. Murakami, T. Kim, K. Tomoda, Y. Narumi, M. Sakon, K. Wakasa, H. Nakamura
    A patient with combined hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCC) underwent partial hepatectomy, and the correlation between the pathological and radiological findings was examined retrospectively. The tumor showed hypoattenuation and hypoenhancement relative to the surrounding liver parenchyma on noncontrast and postcontrast CT, respectively. Both the HCC and CCC components of the tumor showed hypointensity and heterogeneous hyperintensity on T1- and T2-weighted spin echo images, respectively. While the HCC component of the tumor showed hyperenhancement relative to the liver parenchyma on arterial phase images of dynamic MR imaging, the CCC component showed hypoenhancement. When components with different degrees of vascularity are seen in a hepatic tumor, combined HCC and CCC should be considered.
    1997年, Radiation Medicine - Medical Imaging and Radiation Oncology, 15(4) (4), 243 - 246, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Spontaneous bacterial peritonitis in Cirrhosis: Enhancement of ascites on delayed MR imaging
    M. Kanematsu, H. Hoshi, T. Murakami, K. Tsuda, R. Yokoyama, H. Nakamura
    Delayed contrast enhancement of ascites in MR imaging performed in a 61- year-old cirrhotic patient who developed spontaneous bacterial peritonitis is discussed. Delayed T1-weighted spin-echo MR images after the IV injection of gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) showed remarkable enhancement of ascites. The ascites showed marked elevation in total protein value and neutrophil count, establishing a diagnosis of spontaneous bacterial peritonitis. This case suggests the potency of delayed-enhancement MR imaging for the prediction of spontaneous bacterial peritonitis in cirrhotic patients.
    1997年, Radiation Medicine - Medical Imaging and Radiation Oncology, 15(3) (3), 185 - 187, 英語
    [査読有り]
    研究論文（学術雑誌）

  • CT guided percutaneous microwave tumor coagulation therapy for local recurrence of rectal cancer
    T. Ishida, M. Yoshii, T. Murakami, T. Sato, T. Niinobu, T. Shibata
    Purpose: To evaluate the usefulness of the CT guided percutaneous microwave tumor coagulation (PMTC) therapy for local recurrence of rectal cancer. Materials and Methods: The CT guided PMTC was performed for two patients with local recurrence of rectal cancer. Maximum axial diameter of the tumor was 30 mm on CT images. With patients in the prone position on the CT table, a 14-gauge needle-electrode was used to penetrate the tumor under epidural and local anesthesia. PMTC was performed with an output of 60 watts for 60 seconds at a time. Effects of the PMTC were evaluated by CT images obtained three months after the therapy. Results: In both cases, there was no evidence of tumor growth on the CT images. Clinical symptoms disappeared soon after the therapy, and no major complication was observed. Conclusion: The CT guided PMTC therapy was useful for local recurrence of rectal cancer.
    1997年, Japanese Journal of Cancer and Chemotherapy, 24(12) (12), 1851 - 1853, 日本語
    [査読有り]
    研究論文（学術雑誌）

  • The change of hepatic energy status after transcatheter arterial embolization (TAE) for hepatocellular carcinoma - A study using 31P-MRS
    K. Taniguchi, T. Kaminaga, M. Sakon, K. Umeshita, T. Yamada, Y. Takeda, N. Higaki, T. Aoki, H. Ohzato, Y. Hasuike, M. Gotoh, T. Murakami, H. Nakamura, M. Monden
    In six patients with hepatocellular carcinoma, adenosine triphosphate (ATP), phosphomonoester (PME), phosphoric acid (Pi), and pH were measured before and after transcatheter arterial embolization (TAE), using 31P- magnetic resonance spectroscopy (MRS). The effectiveness of TAE was judged by the extent of lipiodol accumulation within the tumor and change in serum alphafetoprotein level. The pH within the tumor decreased 2 -9 days after TAE in all the cases, and βATP/Pi ratio decreased when TAE was effective, whereas the ratio did not decrease when TAE was ineffective. The βATP/Pi ratio measured by 31P-MRS seems to be a useful, non-invasive marker of the anti-tumor effect of TAE, although further investigation is needed.
    1997年, Japanese Journal of Cancer and Chemotherapy, 24(12) (12), 1632 - 1634, 日本語
    [査読有り]
    研究論文（学術雑誌）

  • Preliminary Evaluation of the Apparent Diffusion Coefficient of the Kidney with a Spiral IVIM Sequence
    Kyo Tsuda, Takamichi Murakami, Kousuke Sakurai, Koushi Harada, Tonsok Kim, Satoru Takahashi, Kaname Tomoda, Yoshifumi Narumi, Hironobu Nakamura, Masaaki Izumi, Tetsuji Tsukamoto
    We examined the usefulness of the spiral intravoxel incoherent motion (IVIM) sequence in measuring the apparent diffusion coefficient (ADC)of the kidneys. Five volunteers and five patients with chronic renal failure underwent diffusion-sensitive magnetic resonance imaging of the kidneys with the spiral IVIM sequence. The ADC values in patients with chronic renal failure were significantly lower than those in the renal cortex of volunteers. The mean value of ADC in patients with chronic renal failure was lower than that in volunteers, although there was no statistically significant difference. In volunteers, the ADC of the renal cortex was significantly higher than that of the renal medulla. The phantom study indicated that the accuracy of ADC depended on the signal to noise ratio. A spiral IVIM sequence with a high enough signal to noise ratio may be useful in evaluating renal function, especially that of the cortex.
    1997年, Nippon Acta Radiologica, 57(1) (1), 19 - 22, 日本語
    [査読有り]
    研究論文（学術雑誌）

  • Dynamic MR imaging for extraserosal invasion of advanced gastric cancer
    H Oi, M Matsushita, T Murakami, H Nakamura
    Dynamic magnetic resonance (MR) images in 37 patients with gastric cancers were obtained by a two-dimensional fast multiplanar spoiled gradient technique. The degree of tumor invasion was classified into four grades regarding a low-intensity band between the stomach and surrounding fat. Advanced gastric cancer was strongly enhanced, appearing as a thickened wall, by the contrast medium during the early to delayed phases of dynamic studies, The extent of invasion of the adjacent organs was diagnosed by the difference in enhancement between the tumor and the parenchyma, The sensitivity of extraserosal invasion was 93%, Dynamic MR diagnosis is useful for evaluating the extent of gastric carcinoma.
    SPRINGER VERLAG, 1997年01月, ABDOMINAL IMAGING, 22(1) (1), 35 - 40, 英語
    [査読有り]
    研究論文（学術雑誌）

  • MR imaging of cervical carcinoma: Comparison among T2-weighted, dynamic, and postcontrast T1-weighted images with histopathological correlation
    K Tsuda, T Murakami, H Kurachi, H Ogawa, H Oi, A Miyake, Y Narumi, H Nakamura
    Background: To identify the reasons for misdiagnosis of the degree of stromal invasion by uterine cervical cancer with various magnetic resonance sequences. Methods: T2-weighted, dynamic, and postcontrast T1-weighted images were obtained in the sagittal plane in 20 patients with uterine cervical cancer, After evaluating these sequences for the degree of stromal invasion, histologic specimens were directly correlated with these images. Results: The degree of stromal invasion was correctly diagnosed in 15 of the 20 cases on T2-weighted images, in 12 on dynamic images, and in eight on postcontrast T1-weighted images. All misdiagnoses were due to overestimation. Histologically, peritumoral stroma showed inflammation or edema in two patients, whereas no histological abnormality was found in the other patients. A hyperintense rim, i.e., a peritumoral enhanced ring-shaped structure, was observed on the enhanced images of five patients. The hyperintense rim corresponded to the periphery of the tumor in three patients and to the cervical stroma in two patients. Conclusion: T2-weighted images permitted the most accurate evaluation of stromal invasion by uterine tumors. Overdiagnosis may be due to an abnormal intensity of the cervical stroma, which was observed more frequently on dynamic and postcontrast T1-weighted images than on T2-weighted images.
    SPRINGER VERLAG, 1997年01月, ABDOMINAL IMAGING, 22(1) (1), 103 - 107, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hepatic malignancies: Usefulness of acquisition of multiple arterial and portal venous phase images at dynamic gadolinium-enhanced MR imaging
    MS Peterson, RL Baron, T Murakami
    PURPOSE: To determine whether liver tumor detection is increased by acquiring multiple dynamic arterial phase and portal venous phase magnetic resonance (MR) images. MATERIALS AND METHODS: Dynamic MR imaging was performed in 205 patients at 1.5 T with use of a fast spoiled gradient-echo technique (repetition time, 9-12 msec; echo time, 2.1-3.0 msec; flip angle, 30 degrees). During intravenous bolus injection of gadopentetate dimeglumine or gadoteridol (0.1 mmol/kg), nine images were acquired at each of 10-12 locations over approximately 120 seconds. The number of tumors detected on arterial phase and portal venous phase images and unenhanced T1- and T2-weighted spin-echo (SE) images was evaluated separately. Data obtained in 75 patients with proved malignancies were analyzed. RESULTS: At imaging, 220 malignant tumor nodules were depicted. At prospective review of all images, 110 hepatocellular carcinomas (HCCs) were detected: 82 (75%) on unenhanced T1-weighted SE images, 83 (75%) on unenhanced T2-weighted SE images, 92 (84%) on arterial phase images, and 76 (69%) on portal venous phase images. At prospective review, eight HCCs were detected on only arterial phase images, one on only portal venous phase images, nine on both arterial and portal venous phase images, and 11 on only unenhanced SE images. The 18 additional HCCs detected prospectively on only dynamic images increased HCC detection by 21% over prospective detection on only SE images. Detection of non-HCC tumors (including metastases) did not increase with dynamic images. CONCLUSION Acquisition of multiple dynamic arterial phase and portal venous phase images increased detection of HCC but not metastases.
    RADIOLOGICAL SOC NORTH AMER, 1996年11月, RADIOLOGY, 201(2) (2), 337 - 345, 英語
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    研究論文（学術雑誌）

  • Vaginal arteriovenous malformation: MR imaging
    K Matsumoto, H Kurachi, T Murakami, Y Narumi, K Tsuda, K Yoshino, H Nakamura, A Miyake
    Vaginal arteriovenous malformations (AVMs), although rare, can lead to life-threatening complications. We report the first case of a vaginal AVM whose diagnosis and follow-up were performed by magnetic resonance imaging (MRI), MRI findings of the AVM are the blood flow-related features within the tumor, such as the phase-shift artifact, paradoxical enhancement, and flow voids.
    SPRINGER VERLAG, 1996年11月, ABDOMINAL IMAGING, 21(6) (6), 554 - 556, 英語
    [査読有り]
    研究論文（学術雑誌）

  • The bladder and bladder tumors: Imaging with three dimensional display of helical CT data
    Y Narumi, T Kumatani, Y Sawai, K Kuriyama, C Kuroda, S Takahashi, T Kim, K Tsuda, T Murakami, H Nakamura
    AMER ROENTGEN RAY SOC, 1996年11月, AMERICAN JOURNAL OF ROENTGENOLOGY, 167(5) (5), 1134 - 1135, 英語
    [査読有り]
    研究論文（学術雑誌）

  • MR evaluation of mediopatellar plica
    K Nakanishi, M Inoue, T Ishida, T Murakami, K Tsuda, J Ikezoe, H Nakamura
    Purpose: Evaluation of the usefulness of MR imaging for diagnosing mediopatellar plica (MP) of the knee joint. Material and Methods: We prospectively examined MR images of 40 knee joints in 30 patients with symptoms. The pulse sequences were SE T1-weighted images (600/26 ms), T2-weighted images (1800/70), and FLASH images (320/15/flip angle 90 degrees). When a low-intensity band was found above the medial condyle of the femur on T1-weighted and T2-weighted MR images, we defined it as MP. We compared these MR findings with arthroscopic findings, including the SAKAKIBARA classification of MP. Results: In 29 of the 40 knee joints in which MP was arthroscopically found, 27 were correctly diagnosed as having MP on MR. In the remaining 11 without MP, 9 were correctly diagnosed by MR. Conclusion: MR images are useful not only for detecting MP but also for evaluating its extension. Our results suggest that MR imaging is useful as a screening method for detecting MP before arthroscopy.
    MUNKSGAARD INT PUBL LTD, 1996年07月, ACTA RADIOLOGICA, 37(4) (4), 567 - 571, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Ciliated foregut cyst in cirrhotic liver
    T Murakami, A Imai, H Nakamura, K Tsuda, T Kanai, K Wakasa
    We encountered a patient with a ciliated hepatic foregut cyst with accompanying liver cirrhosis, which was hard to distinguish from well-differentiated hepatocellular carcinoma. A lesion 2 cm in diameter was found in the subcapsular region of the medial segment of the liver. It was slightly hypoechoic on ultrasonography, of high attenuation on nonenhanced computed tomography (CT), of high intensity on T-1-weighted spin echo images of magnetic resonance imaging (MRI), and of isointensity on T-2-weighted spin echo images. It was not enhanced in the arterial phase images of MRI, and was shown as a complete perfusion defect on CT arterial portography. The cyst was enucleated and found to be filled with bloody mucinous fluid.
    SPRINGER VERLAG, 1996年06月, JOURNAL OF GASTROENTEROLOGY, 31(3) (3), 446 - 449, 英語
    [査読有り]
    研究論文（学術雑誌）

  • CT and NIR imaging of abdominal liposarcoma
    T Kim, T Murakami, H Oi, K Tsuda, M Matsushita, K Tomoda, H Fukuda, H Nakamura
    OBJECTIVE. CT and MR images were reviewed to correlate the histologic subtypes of abdominal liposarcoma with the radiologic findings. SUBJECTS AND METHODS. Ten patients with liposarcoma who underwent CT or MR imaging before surgery were included in this study, CT and MR imaging findings for these patients were compared retrospectively with histologic findings. RESULTS. Major histologic subtypes found in our group of patients were five well-differentiated, three myxoid, one pleomorphic, and one round-cell liposarcomas. The well-differentiated subtype consisted of lipoma-like and/or sclerosing components. The predominant attenuation and signal intensity characteristics of the lipoma-like components on CT and MR images resembled those of fat, whereas the predominant attenuation and signal intensity characteristics of the sclerosing components resembled those of muscle. The myxoid subtype showed, on unenhanced images, predominant attenuation and signal intensity characteristics that resembled those of water; on contrast-enhanced images, this subtype showed gradual reticular enhancement. The appearance of the round-cell and pleomorphic subtypes was that of heterogeneous, nonfatty tumors, Their characteristics were indistinguishable from those of other malignant soft-tissue masses. CONCLUSION. Each histologic subtype of abdominal liposarcoma showed different CT attenuation or MR imaging signal intensity characteristics. A clear understanding of these findings should prove helpful in the diagnosis of liposarcoma.
    AMER ROENTGEN RAY SOC, 1996年04月, AMERICAN JOURNAL OF ROENTGENOLOGY, 166(4) (4), 829 - 833, 英語
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    研究論文（学術雑誌）

  • Value of gonadotropin-releasing hormone agonist in diagnosing peritoneal pseudocysts
    H Kurachi, T Murakami, T Maeda, K Tsuda, O Higashiguchi, H Nakamura, A Miyake
    MUNKSGAARD INT PUBL LTD, 1996年03月, ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 75(3) (3), 294 - 297, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Dynamic MR imaging and early-phase helical CT for detecting small intrahepatic metastases of hepatocellular carcinoma
    H Oi, T Murakami, T Kim, M Matsushita, H Kishimoto, H Nakamura
    OBJECTIVE. We performed a study to evaluate the sensitivities of multislice dynamic MR imaging and early-phase helical CT as noninvasive methods for detecting small intrahepatic metastases of hepatocellular carcinomas. MATERIALS AND METHODS. Dynamic and spin-echo MR imaging and early- and delayed-phase helical CT of the liver were performed for patients with multiple hepatocellular carcinomas before transcatheter arterial chemoembolization. Forty-nine patients had 242 intrahepatic metastases less than 3 cm in diameter. Using iodized-oil CT after transcatheter arterial chemoembolization as a gold standard, the sensitivity of MR imaging for detecting intrahepatic metastases was compared with that of CT. RESULTS. Of the 242 nodules, 225 were diagnosed as hepatocellular carcinomas by iodized-oil CT. Of these, dynamic MR imaging depicted 140 nodules and early-phase CT depicted 106. The sensitivities of dynamic MR imaging and early-phase CT were significantly Superior to those of spin-echo MR imaging (p < .0001) and delayed-phase CT (p < .0001) for tumors less than 1 cm in diameter. CONCLUSION. Dynamic MR imaging and early-phase CT of the liver are the most sensitive noninvasive means of detecting small intrahepatic metastases of hepatocellular carcinomas before and after treatment.
    AMER ROENTGEN RAY SOC, 1996年02月, AMERICAN JOURNAL OF ROENTGENOLOGY, 166(2) (2), 369 - 374, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 3DFT-flash MR imaging of pancreatic cancer with gadopentetate dimeglumine
    T. Murakami, K. Tsuda, H. Nakamura, K. Osuga, K. Tomoda, S. Hori, M. Miyata, M. Monden, K. Wakasa
    Purpose: We evaluated the usefulness of dynamic 3-dimensional Fourier transformation (3DFT) fast low angle shot (FLASH) MR imaging using gadopentetate dimeglumine (Gd-DTPA) to assess the extent of pancreatic cancer. Material and Methods: Breath-hold 3DFT-FLASH MR images (20/4 25° flip angle 7 partitions 3-5-mm slice thickness) were obtained before the administration of 0.1 mmol/kg of Gd-DTPA, just after (early phase), and 1 and 2 min (late phases) after in 14 patients with pancreatic cancer. All patients underwent surgical removal or laparotomy. We compared the findings of T1-, T2-, and postcontrast T1-weighted spin-echo (conventional SE) and 3DFT-FLASH imaging with histologic or surgical findings. Results: Dynamic MR images could delineate the pancreatic tumors more clearly than the conventional SE images, and were useful for diagnosing vessel invasion. The contrast-to-noise ratio between the pancreatic cancer and the surrounding pancreatic parenchyma was significantly higher with the dynamic 3DFT-FLASH image than with the conventional SE images (p0.01). Conclusion: Dynamic 3DFT-FLASH MR imaging with Gd-DTPA is useful in delineating and evaluating the extent of pancreatic cancer. Copyright © Acta Radiologica 1996.
    1996年, Acta Radiologica, 37(2) (2), 190 - 194, 英語
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    研究論文（学術雑誌）

  • DETECTION OF HYPERVASCULAR HEPATOCELLULAR-CARCINOMA BY DYNAMIC MRI AND DYNAMIC SPIRAL CT
    T KIM, T MURAKAMI, H OI, M MATSUSHITA, H KISHIMOTO, H IGARASHI, H NAKAMURA, J OKAMURA
    Objective: Our goal was to evaluate the detectability of hypervascular hepatocellular carcinomas (HCCs) by multislice dynamic MRI and dynamic spiral CT. Materials and Methods: Prior to transcatheter arterial chemoembolization (TACE) with iodized oil, the liver was subjected to T1- and T7-weighted SE-MRI, multislice dynamic MRI after intravenous bolus injection of Gd-DTPA, early phase imaging with spiral CT (dynamic spiral CT) after intravenous bolus injection of contrast medium (at a rate of 2 or 3 ml/s), and delayed phase CT in 64 patients with 208 HCC nodules. The detectability of HCCs by MRI and CT was evaluated retrospectively compared with CT after TACE as a gold standard. Results: The detectability of nodules <1 cm in diameter was superior with dynamic MRI (67%) and dynamic spiral CT (50%) in comparison with SE-MRI (26%) and delayed phase CT (11%) (p < 0.01). The detectability of these tumors with dynamic MRI was significantly superior to that with dynamic spiral CT using an injection rate of 2 ml/s (p < 0.01), but not significantly different from that of dynamic spiral CT using a rate of 3 ml/s. Conclusion: Dynamic MRI and dynamic spiral CT are comparable for detecting hypervascular intrahepatic metastases of HCC.
    LIPPINCOTT-RAVEN PUBL, 1995年11月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 19(6) (6), 948 - 954, 英語
    [査読有り]
    研究論文（学術雑誌）

  • INTRAMURAL INVASION OF GASTRIC-CANCER - EVALUATION BY CT WITH WATER-FILLING METHOD
    K TSUDA, S HORI, T MURAKAMI, H NAKAMURA, K TOMODA, K NAKANISHI, H SHIOZAKI
    Objective: Our goal was to clarify the ability of CT to evaluate intramural invasion of gastric cancer. Materials and Methods: We reviewed bolus-enhanced CT images performed with orally administered 40-600 ml of water in 59 early gastric cancers and 22 advanced gastric cancers mimicking early gastric cancers macroscopically. Results: CT was able to reveal 49% of early gastric cancers and 68% of advanced gastric cancers mimicking early cancers. Twenty-seven gastric tumors were detected in two or three layered structure of wall. Morphologic features of early gastric cancers are strong enhancement without wall thickening and thickened inner layer with normal middle and outer layers. Morphologic features of early advanced gastric cancers are a thickened wall with disappeared middle and outer layers and transmural enhancement with wall thickening. If one of these features was used to predict whether the tumor was early or early advanced gastric cancer in detected cases, specificity was 93-100%, sensitivity was 7-72%, and positive predictive value was 80-100%. Conclusion: We evaluated whether the wall pattern of gastric tumors on CT can provide useful information about intramural invasion.
    LIPPINCOTT-RAVEN PUBL, 1995年11月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 19(6) (6), 941 - 947, 英語
    [査読有り]
    研究論文（学術雑誌）

  • DETECTABILITY OF HYPERVASCULAR HEPATOCELLULAR-CARCINOMA BY ARTERIAL PHASE IMAGES OF MR AND SPIRAL CT
    T MURAKAMI, T KIM, H OI, H NAKAMURA, H IGARASHI, M MATSUSHITA, J OKAMURA, T KOZUKA
    The ability of arterial phase images of breath-hold MR imaging and spiral CT to detect hypervascular hepatocellular carcinomas (HCCs) was evaluated. Prior to transcatheter arterial chemoembolization (TACE) with iodized oil, MR images and spiral CT during i.v. bolus injection of contrast medium (IV-MR imaging and IV-spiral CT) and spiral CT during intraarterial injection of contrast media through catheter (IA-spiral CT) of the entire liver were obtained in 24 consecutive patients with 93 HCCs. In the detection of HCCs less than 1 cm in diameter, IA-spiral CT (87.3%) was superior to IV-MR imaging (63.5%) and IV-spiral CT (54.0%) (p <0.001). There was no significant difference in detectability in any tumor size between IV-MR imaging and IV-spiral CT IA-spiral CT was the best for detecting hypervascular HCCs, and there was no significant difference between IV-MR imaging and IV-spiral CT.
    MUNKSGAARD INT PUBL LTD, 1995年07月, ACTA RADIOLOGICA, 36(4) (4), 372 - 376, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Cervical invasion of endometrial carcinoma - evaluation by parasagittal MR imaging
    T. Murakami, H. Kurachi, H. Nakamura, K. Tsuda, A. Miyake, K. Tomoda, S. Hori, T. Kozuka
    Twenty-seven consecutive patients were examined by T2-(1 800/70 ms) and postcontrast T1-weighted (600/15) spin echo (SE) or dynamic (200/15) SE MR imaging to determine the usefulness of parasagittal MR imaging in assessing cervical invasion of endometrial carcinoma. The images were obtained in a direction parallel to the longitudinal axis of the uterus (parasagittal). The cervical epithelium, being hyperintense on the late phase dynamic and postcontrast T1-weighted SE images, had disappeared partially or totally in all 4 patients with cervical invasion. The enhanced cervical epithelium was completely seen in one patient with the tumor protruding into the cervical canal in a polyp-like form without cervical epithelial invasion. The same was also seen in the 22 patients with the tumor remaining in the corpus cavity. The enhanced parasagittal MR images facilitated the evaluation of the extent of the endometrial carcinoma.
    1995年05月, Acta Radiologica, 36(3) (3), 248 - 253, 英語
    [査読有り]
    研究論文（学術雑誌）

  • MRI OF PLACENTAL POLYPS
    H KURACHI, T MAEDA, T MURAKAMI, K TSUDA, M SAKATA, H NAKAMURA, A MIYAKE
    Objective: Placental polyp is intrauterine polypoid placental tissue retained after delivery or abortion and may cause life-threatening bleeding. We studied the value of MRI in diagnosing placental polyps. Material and Methods: Two women, 26 and 32 years old, with histologically proven placental polyp were included in this study. These patients were treated with local injections of methotrexate or transcatheter arterial embolization. The MR images before and after these treatments were studied retrospectively. Results: High intensity pedunculated masses of 3-4 cm in size were observed in the expanded uterine cavity on T2-weighted and contrast-enhanced T1-weighted SE images. Bloody contents were observed around the masses. Placental polyps were more intensely enhanced than the myometrium by the contrast media, and the enhanced T1-weighted images indicated the retained placental tissues with an adherent part to the myometrium. Magnetic resonance imaging was also useful in following up the reduction in the size of the lesions and in the blood flow after the treatments. Conclusions: Magnetic resonance imaging may be useful in diagnosing and following up placental polyps.
    LIPPINCOTT-RAVEN PUBL, 1995年05月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 19(3) (3), 444 - 448, 英語
    [査読有り]
    研究論文（学術雑誌）

  • CERVICAL INVASION OF ENDOMETRIAL CARCINOMA - EVALUATION BY PARASAGITTAL MR-IMAGING
    T MURAKAMI, H KURACHI, H NAKAMURA, K TSUDA, A MIYAKE, K TOMODA, S HORI, T KOZUKA
    Twenty-seven consecutive patients were examined by T2-(1 800/70 ms) and postcontrast T1-weighted (600/15) spin echo (SE) or dynamic (200/15) SE MR imaging to determine the usefulness of parasagittal MR imaging in assessing cervical invasion of endometrial carcinoma. The images were obtained in a direction parallel to the longitudinal axis of the uterus (parasagittal). The cervical epithelium, being hyperintense on the late phase dynamic and postcontrast T1-weighted SE images, had disappeared partially or totally in all 4 patients with cervical invasion. The enhanced cervical epithelium was completely seen in one patient with the tumor protruding into the cervical canal in a polyp-like form without cervical epithelial invasion. The same was also seen in the 22 patients with the tumor remaining in the corpus cavity. The enhanced parasagittal MR images facilitated the evaluation of the extent of the endometrial carcinoma.
    MUNKSGAARD INT PUBL LTD, 1995年05月, ACTA RADIOLOGICA, 36(3) (3), 248 - 253, 英語
    [査読有り]
    研究論文（学術雑誌）

  • HEPATOCELLULAR-CARCINOMA - EFFICACY OF TRANSCATHETER OILY CHEMOEMBOLIZATION IN RELATION TO MACROSCOPIC AND MICROSCOPIC PATTERNS OF TUMOR-GROWTH AMONG 100 PATIENTS WITH PARTIAL-HEPATECTOMY
    T HASHIMOTO, H NAKAMURA, S HORI, K TOMODA, K NAKANISHI, T MURAKAMI, T KOZUKA, M MONDEN, M GOTOH, C KURODA, K WAKASA, M SAKURAI
    Purpose: To evaluate the efficacy of transcatheter oily chemoembolization (TOCE) for hepatocellular carcinoma (HCC) on the basis of microscopic and macroscopic findings postembolization. Methods: HCCs ranging in size from 0.5 to 13 cm (mean 3.6 cm) were obtained from partial hepatectomies of 100 consecutive patients who had undergone TOCE between 20 and 246 days (mean 59.5 days) prior to surgery. The efficacy of TOCE was assessed on the basis of the necrotic to live cell ratio of the tumors. The microscopic pattern of tumor growth was grouped into expanding type (complete capsule formation) and replacing type (incomplete or no capsule). There were five types of macroscopic groupings: single nodule, single nodule with extranodular growth (SNE), contiguous and noncontiguous multinodular, and massive growth type. Results: Among 79 cases with the expanding type, 29 (37%) had 100% HCC necrosis, but none with 100% necrosis were in the replacing type. By macroscopic grouping, the efficacy of TOCE decreased from the single nodule type (50% of patients had 100% necrosis) to the SNE type (21%), and the other types (9%). Conclusion: TOCE appears to be most efficacious for HCC with the expanding growth pattern and HCC forming single nodules. Poor results are to be expected in HCC of replacing growth type and multinodular or massive growth types.
    SPRINGER VERLAG, 1995年03月, CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 18(2) (2), 82 - 86, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Super selective angiography using flow guide catheter (MAGIC HO 1)
    K. Tomoda, S. Hori, T. Murakami, K. Nakanishi, T. Hashimoto, T. Ishida, K. Tsuda, H. Nakamura, M. Matsushita
    A new type of flow guide catheter was developed for hepatic angiography and embolization. The catheter consists of two components the distal portion is a flexible part and has a ball tip at the end, so that it can be easily advanced to the periphery, but the proximal portion has a hard shaft. It has superior maneuver ability compared with the present type of supple catheter. Catheterization of the hepatic artery can be achieved more easily using this new type catheter.
    1995年, Japanese Journal of Clinical Radiology, 40(3) (3), 319 - 323, 日本語
    研究論文（学術雑誌）

  • TIME-OF-FLIGHT MR-ANGIOGRAPHY OF PORTAL SYSTEM AND COLLATERALS IN PORTAL-HYPERTENSION USING A 2-DFT FAST SPOILED GRADIENT RECALLED STEADY-STATE PRECESSION TECHNIQUE
    T MURAKAMI, H IGARASHI, H OI, M MATSUSHITA, T KIM, H KISHIMOTO, H NAKAMURA, J OKAMURA, T KOZUKA
    MR angiographic examinations were performed in 26 patients. Approximately 30 contiguous fast spoiled GRASS images (8.1/3.1/30 degrees, TR/TE/flip angle) were acquired during single breath-holding for about 35 s, and then new images were reconstructed with maximum intensity projection technique. Spoiled GRASS images (40/ 12/40) of 2 to 3 slices were taken during breath-holding for about 13 s, and these processes were repeated to obtain about 30 individual images for conventional MR angiography. The new MR angiograms were compared quantitatively and qualitatively with conventional MR angiograms with arterial portography as the gold standard. The new MR angiograms could visualize blood vessels with smooth margins, and provided almost the same anatomic information about the portal Vein and collateral vessels as the conventional MR angiograms. Contrast-to-noise ratios between the portal or hepatic Vein and liver parenchyma were significantly higher with fast spoiled GRASS images. The new MR angiograms using fast spoiled GRASS images provided useful diagnostic mapping of the collateral Venous pathways within a shorter examination time.
    MUNKSGAARD INT PUBL LTD, 1994年11月, ACTA RADIOLOGICA, 35(6) (6), 581 - 585, 英語
    [査読有り]
    研究論文（学術雑誌）

  • MR-IMAGING OF MIXED HEPATOCELLULAR AND CHOLANGIOCELLULAR CARCINOMA
    T HASHIMOTO, H NAKAMURA, S HORI, K TOMODA, T MITANI, T MURAKAMI, T KOZUKA, M MONDEN, K WAKASA, M SAKURAI
    Two patients with mixed hepatocellular and cholangiocellular carcinoma underwent partial hepatectomy after magnetic resonance (MR) imaging. Correlation is made with the histopathologic manifestations. In both cases the tumors showed relative low signal intensities on T1-weighted spin-echo (SE) images and high signal intensities on T2-weighted SE images. Dynamic MR imaging showed the enhancement from the periphery of the tumor to the inner area gradually and the enhancement continued into the delayed phase. With both cases fibrosis was marked in the inner area of the tumor compared to the peripheral area. The extent and degree of fibrotic tissue is considered to reflect the enhancement on dynamic MR imaging.
    SPRINGER VERLAG, 1994年09月, ABDOMINAL IMAGING, 19(5) (5), 430 - 432, 英語
    [査読有り]
    研究論文（学術雑誌）

  • TRANSTHORACIC PERCUTANEOUS ETHANOL INJECTION INTO THE LIVER
    K TOMODA, S HORI, H NAKAMURA, T HASHIMOTO, T MURAKAMI, K TSUDA, T ISHIDA, T KOZUKA
    RATIONALE AND OBJECTIVES. The feasibility of the new transthoracic approach of percutaneous ethanol injection through the lower lung to the subphrenic region of the liver was evaluated in normal rats. METHODS. Fourteen normal rats received percutaneous ethanol injection. A 22-gauge fine needle was inserted into the liver via the thoracic cage and through the lower lung parenchyma under computed tomographic (CT) guidance. After ethanol (0.1-0.2 mL) was injected, three follow-up CT scans were performed: immediately after, 1 day after, and 1 week after the initial injection. All animals were killed 1 week after injection to evaluate macroscopic changes of the diaphragm and pleura. RESULTS. No major complications were observed. Minor complications were observed in six rats; these included one pneumothorax (7%) and five band-like and streaky shadows (presumably pulmonary hemorrhages) (35%) on the CT scan obtained immediately after the procedure. However, all complications had disappeared spontaneously in the follow-up CT scan obtained 1 day after the procedure. At autopsy, no pleural changes were seen. CONCLUSIONS. This study demonstrates that percutaneous ethanol injection through the lower lung parenchyma is achievable. Although this study was performed only in normal rats, the transthoracic approach can be a complementary method of ultrasound-guided percutaneous ethanol injection for tumors in the subphrenic region of the liver. Further study will be needed in abnormal livers and then in human subjects to verify the safety and efficacy of this procedure.
    LIPPINCOTT-RAVEN PUBL, 1994年09月, INVESTIGATIVE RADIOLOGY, 29(9) (9), 839 - 841, 英語
    [査読有り]
    研究論文（学術雑誌）

  • EXTRASEROSAL INVASION IN ADVANCED GASTRIC-CANCER - EVALUATION WITH MR-IMAGING
    M MATSUSHITA, H OI, T MURAKAMI, N TAKATA, T KIM, H KISHIMOTO, H NAKAMURA, S OKAMOTO, J OKAMURA
    PURPOSE: To evaluate the usefulness of magnetic resonance (MR) imaging in the diagnosis of extraserosal invasion in advanced gastric cancer. MATERIALS AND METHODS: MR imaging was performed in 48 patients with advanced gastric cancer, and the results were correlated with the histopathologic findings. Images perpendicular to the gastric wall with cancer were obtained with spoiled gradient-recalled acquisition in the steady state (GRASS). The degree of serosal invasion was classified on the basis of the appearance of a low-signal-intensity band around the lesion. RESULTS: Advanced gastric cancer appeared as a thickened wall of high signal intensity after the administration of contrast material. A low-signal-intensity band disappeared or showed irregularity in the area of extraserosal invasion by the gastric cancer. The MR imaging-determined grade correlated with the histopathologic findings for 11 of 14 (79%) pT2 tumors, 23 of 24 (96%) pT3 tumors, and eight of 10 (80%) pT4 tumors. The overall accuracy was 88%. CONCLUSION: Presence of a low-signal-intensity band at MR imaging is useful for the preoperative evaluation of serosal invasion.
    RADIOLOGICAL SOC NORTH AMER, 1994年07月, RADIOLOGY, 192(1) (1), 87 - 91, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 5-YEAR SURVIVAL AFTER TRANSCATHETER CHEMOEMBOLIZATION FOR HEPATOCELLULAR-CARCINOMA
    H NAKAMURA, T MITANI, T MURAKAMI, T HASHIMOTO, K TSUDA, K NAKANISHI, T ISHIDA, K TOMODA, S HORI, T KOZUKA, M MONDEN, C KURODA
    The 5-year cumulative survival rate of 443 patients who underwent transcatheter chemoembolization (TCE) for non-resectable hepatocellular carcinoma (HCC) before December 1986 was 8.0%, and 29 patients survived for 5 years or more. Of these 29 patients, 25 were men and 4 were women; their mean age was 63.9 years. Macroscopic classification showed lesions of the single nodular type in 16 cases, the multiple nodular type in 10 cases, and the massive type in 3 cases; 12 of the single nodular lesions measured 5 cm or less in size. The TNM classification showed lesions of stage I in 3 cases, stage II in 14 cases, stage III in 6 cases, and stage IV in 6 cases. Lesions classified as Child A were found in 23 patients, and they were thus much more common than Child B lesions (2 patients) and Child C lesions (1 patient). The response was analyzed in relation to the use of iodized oil (Lipiodol). It was used in 215 of the patients, and the 5-year cumulative survival rate of those patients was 12.9% (23 of them survived for 5 years or more). Lipiodol was not used in 228 patients, and they showed a 5-year cumulative survival rate of 3.4%, with 6 patients surviving for 5 years or more. The 6 patients with stage III disease and the 6 with stage IV disease received Lipiodol. TCE with Lipiodol thus contributed greatly in prolonging the survival of patients with HCC complicated by intrahepatic metastases or intraportal tumor thrombi.
    SPRINGER VERLAG, 1994年02月, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 33, S89 - S92, 英語
    [査読有り]
    研究論文（学術雑誌）

  • NEW DEVELOPMENT OF TRANSARTERIAL IMMUNOEMBOLIZATION (TIE) FOR THERAPY OF HEPATOCELLULAR-CARCINOMA WITH INTRAHEPATIC METASTASES
    T KANAI, M MONDEN, M SAKON, M GOTOH, K UMESHITA, Y HASUIKE, H NAKANO, T MONDEN, T MURAKAMI, H NAKAMURA, K WAKASA, M SAKURAI, J OKAMURA, T MORI
    The prognosis of patients with multiple hepatocellular carcinoma (HCC) remains disappointing. In this study, we devised a new therapeutic modality for HCC consisting of transarterial immunoembolization (TIE) using OK-432 and fibrinogen and then analyzed the preliminary results. In the first series, we applied the treatment to 19 patients with advanced HCC who had proved to be insensitive to several previous conventional treatments. In all, 14 patients (74%) with unresected HCC have currently survived for between 2 and 16 months after TIE. The remaining 5 patients died at 17, 14, 8, 7, and 4 months after TIE. The serum levels of tumor markers decreased in all of the patients, and a marked reduction in tumor size was observed in six patients after TIE. A high fever occurred in all cases, and abdominal pain and loss of appetite were also observed after TIE. However, deterioration of liver function was negligible. After confirmation of the safety of this method, we started a second study series in which this TIE treatment was selected as the first choice. Six patients have been treated to date. All patients in this group underwent hepatic resection at 6-48 days following TIE. Histological examination of the resected specimens following TIE showed massive infiltration of mononuclear cells around tumor cell nests and lytic necrosis as well as coagulation necrosis of the main tumor and the intrahepatic metastases. In conclusion, our results indicate that TIE may be a safe and promising therapy for patients with HCC.
    SPRINGER VERLAG, 1994年02月, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 33, S48 - S54, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hironobu Nakamura, Takashi Mitani, Takamichi Murakami, Toru Hashimoto, Kyo Tsuda, Katsuyuki Nakanishi, Takeshi Ishida, Kaname Tomoda, Shinichi Hori, Takahiro Kozuka, Morito Monden, Chikazumi Kuroda
    The 5-year cumulative survival rate of 443 patients who underwent transcatheter chemoembolization (TCE) for non-resectable hepatocellular carcinoma (HCC) before December 1986 was 8.0%, and 29 patients survived for 5 years or more. Of these 29 patients, 25 were men and 4 were women their mean age was 63.9 years. Macroscopic classification showed lesions of the single nodular type in 16 cases, the multiple nodular type in 10 cases, and the massive type in 3 cases 12 of the single nodular lesions measured 5 cm or less in size. The TNM classification showed lesions of stage I in 3 cases, stage II in 14 cases, stage III in 6 cases, and stage IV in 6 cases. Lesions classified as Child A were found in 23 patients, and they were thus much more common than Child B lesions (2 patients) and Child C lesions (1 patient). The response was analyzed in relation to the use of iodized oil (Lipiodol). It was used in 215 of the patients, and the 5-year cumulative survival rate of those patients was 12.9% (23 of them survived for 5 years or more). Lipiodol was not used in 228 patients, and they showed a 5-year cumulative survival rate of 3.4%, with 6 patients surviving for 5 years or more. The 6 patients with stage III disease and the 6 with stage IV disease received Lipiodol. TCE with Lipiodol thus contributed greatly in prolonging the survival of patients with HCC complicated by intrahepatic metastases or intraportal tumor thrombi. © 1994 Springer-Verlag.
    Springer-Verlag, 1994年01月, Cancer Chemotherapy and Pharmacology, 33(1) (1), S89 - S92, 英語
    研究論文（学術雑誌）

  • Doses of epirubicin used in oily chemoembolization of hepatocellular carcinoma
    H. Nakamura, T. Murakami, K. Tomoda, K. Nakanishi, S. Hori, H. Oi, I. Tsukaguchi, H. Watanabe, M. Masuike, Y. Inoue
    Epirubicin (EPIR), an anticancer agent, has recently been used with increasing frequency in transcatheter oily chemoembolization (TOCE) of hepatocellular carcinoma. We conducted a dose-finding study of EPIR with regard to its safety. One hundred thirty-four patients were divided into five groups according to the EPIR doses (mg/m2), Group A (< 30 mg/m2), Group B (≥30-< 40 mg/m2), Group C (≥40-< 50 mg/m2), Group D (≥50-< 60 mg/m2), and Group E (≥60 mg/m2). The number of leukocytes decreased at 2 weeks but recovered at 4 weeks with no significant differences among the groups. However, there were significantly fewer leukocytes in Group E than in Groups A to D. There were no significant differences among the groups in either the number of erythrocytes or platelets. The number of platelets tended to remain at increased levels even at 4 weeks. Liver function as represented by GOT, GPT, LDH, and total bilirubin was not aggravated, but tended to improve. GOT and LDH in Groups D and E, in particular, improved significantly at 4 weeks, probably because of the antitumor effect of TOCE. These results suggest that EPIR can be administered up to 50 mg/m2 for TOCE.
    1994年, Japanese Journal of Cancer and Chemotherapy, 21(13) (13), 2218 - 2221, 日本語
    [査読有り]
    研究論文（国際会議プロシーディングス）

  • Lymphangioma of the mesentery and small intestine: A case report showing a solid tumor with a cystic component on US and CT
    K. Tsuda, T. Murakami, H. Nakamura, T. Kozuka, H. Yamanishi, M. Miyata, H. Fukuda
    We encountered a patient with multiple lymphangiomas of the mesentery and small intestine. Ultrasonography and computed tomography showed a mesenteric tumor composed of a solid component with a small cystic part. This unusual appearance made the differential diagnosis between lymphangioma and other intra-abdominal solid tumors difficult.
    1994年, Radiation Medicine - Medical Imaging and Radiation Oncology, 12(5) (5), 241 - 243, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 3DFT-FISP MRI WITH GADOPENTETATE DIMEGLUMINE IN DIFFERENTIAL-DIAGNOSIS OF SMALL LIVER-TUMORS
    H NAKAMURA, T MURAKAMI, T ISHIDA, K TSUDA, T HASHIMOTO, K NAKANISHI, T MITANI, K TOMODA, S HORI, T KOZUKA
    Objective: We assessed the value of dynamic sequential three-dimensional Fourier transformation (3DFT) MRI in differentiating various types of small liver tumors. Materials and Methods: Forty-seven patients with 65 liver masses <3 cm in size (42 hepatocellular carcinomas, 11 hemangiomas, 12 metastatic tumors) were studied by 3DFT fast imaging with steady-state precession (FISP) MRI [TR(ms)/TE(ms)/flip angle (degrees): 20/8/30]. The slab thickness was 21-35 mm, and there were seven partitions. The 3DFT-FISP MR images were obtained immediately after 0.1 mmol/kg of gadopentetate dimeglumine was administered intravenously over 2-3 s (early phase), 60 s after (late phase I), and 120 s after (late phase II). Results: Eighty-six percent of small hepatocellular carcinomas showed hyperintense enhancement relative to the surrounding liver parenchyma and iso- or hypointense enhancement with or without capsular enhancement in the late phase. Eighty-two percent of small hemangiomas showed peripheral globular enhancement in the early phase and total hyperintense or peripheral enhancement in the late phases. Ninety-two percent of the small metastatic liver tumors showed doughnut-like ring enhancement in the early phase. Conclusion: By dynamic 3DFT-FISP MRI, we were able to accurately evaluate the hemodynamics and morphological findings of each type of small liver tumor.
    LIPPINCOTT-RAVEN PUBL, 1994年01月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 18(1) (1), 49 - 54, 英語
    [査読有り]
    研究論文（学術雑誌）

  • DISPLAY OF MR ANGIOGRAMS - MAXIMUM INTENSITY PROJECTION VERSUS 3-DIMENSIONAL RENDERING
    T MURAKAMI, T KASHIWAGI, H NAKAMURA, K TSUDA, M AZUMA, K TOMODA, S HORI, T KOZUKA
    Objective: The purpose of this study is to clarify the most useful technique of MR imaging in demonstrating the collateral venous pathways due to portal hypertension. Subjects: Twenty-eight cirrhotic patients with collateral venous pathways due to portal hypertension and three patients without them were studied. We evaluated the detectability of collateral vessels of flow-enhanced transverse MR images by time of flight effect, projection MR angiography using the maximum intensity projection technique and three-dimensional (3D) computer graphic images, by using the arterial portography as the standard. Results: Flow-enhanced transverse MR images showed 98% of the collateral vessels detected by angiography, however, the connection of each vessel was obscure. Fully 81% of the collateral vessels were seen by projection MR angiography, and 98% of them by the 3D computer graphic images. Conclusion: The detectability of collateral vessels of 3D computer graphic imaging was better than that of the projection MR angiography and was as accurate as that of transverse MR imaging. 3D Computer graphic images provided complex anatomical information in a more easily understood fashion than either transverse MR images or projection MR angiography.
    ELSEVIER SCI IRELAND LTD, 1993年09月, EUROPEAN JOURNAL OF RADIOLOGY, 17(2) (2), 95 - 100, 英語
    [査読有り]
    研究論文（学術雑誌）

  • IMAGING OF PERITONEAL PSEUDOCYSTS - VALUE OF MR-IMAGING COMPARED WITH SONOGRAPHY AND CT
    H KURACHI, T MURAKAMI, H NAKAMURA, S HORI, A MIYAKE, T KOZUKA, O TANIZAWA
    OBJECTIVE. Peritoneal pseudocysts are created when fluid arising from the ovary is trapped by peritoneal adhesions. We studied the value of MR imaging, compared with sonography and CT, for detecting these abnormalities. SUBJECTS AND METHODS. Nine women, 27 to 49 years old, who had surgically proved peritoneal pseudocysts were included in the study. All nine patients were premenopausal, and eight had a history of pelvic surgery. All patients were examined with MR imaging and sonography, and five were also examined with CT. Imaging findings were analyzed and compared with the surgical findings. RESULTS. Sonograms in all nine patients showed a thick-walled cyst that contained focal echoes indicating nodules, making it difficult to differentiate these lesions from cystic ovarian tumors. In eight of the nine patients, the fluid in the pseudocysts had low signal intensity on T1-weighted MR images and high signal intensity on T2-weighted spin-echo MR images, suggesting that the fluid was serous. The pseudocyst had an irregular shape on MR images in seven patients and on CT scans in three patients. However, MR provided more information than CT did about the nature of the fluid within the pseudocyst. CONCLUSION. Our study suggests that MR imaging is more useful than sonography and CT for determining the characteristic findings of peritoneal pseudocysts.
    AMER ROENTGEN RAY SOC, 1993年09月, AMERICAN JOURNAL OF ROENTGENOLOGY, 161(3) (3), 589 - 591, 英語
    [査読有り]
    研究論文（学術雑誌）

  • DETECTION OF VIABLE TUMOR-CELLS IN HEPATOCELLULAR-CARCINOMA FOLLOWING TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION WITH IODIZED OIL - PATHOLOGICAL CORRELATION WITH DYNAMIC TURBO-FLASH MR-IMAGING WITH GD-DTPA
    T MURAKAMI, H NAKAMURA, S HORI, K TOMODA, T MITANI, K NAKANISHI, T HASHIMOTO, K TSUDA, T KOZUKA, M MONDEN, K WAKASA
    To evaluate the effect of transcatheter arterial chemoembolization (TACE) with iodized oil for hepatocellular carcinoma (HCC), dynamic turbo-fast low angle shot (turbo-FLASH) (TR/TE/flip angle/TI, 8.5/4.6/10/200) MR imaging with gadopentetate dimeglumine was performed in 10 patients with HCC after TACE with iodized oil and before partial hepatectomy. Immediately after 0.05 mmol/kg b.w. of gadopentetate dimeglumine was administered intravenously, 10 images were obtained in the first 20 s (early phase). Then, one image every 30 s from 1 to 3 min (late phase), and images at 5 min and 7 min (delayed phase) were obtained serially. In the early phase, HCC showed no enhancement in 5 patients, partial hyperintense enhancement in 4, and total hyperintense enhancement in one. Viable regions of the tumor, evaluated at histopathology, showed hyperintense enhancement relative to the surrounding liver parenchyma in the early phase, while necrotic regions showed no enhancement. Both viable and necrotic regions showed lower signal intensities than the surrounding liver parenchyma in both late and delayed phases. By using dynamic turbo-FLASH MR imaging, we were able to accurately evaluate the effect of TACE with iodized oil for HCC in 8 of the 10 patients. In 2 patients, in whom small viable cells were seen in the HCC, viable regions could not be detected with our technique. It is concluded that turbo-FLASH dynamic MR imaging was useful for evaluating the effect of TACE for HCC.
    MUNKSGAARD INT PUBL LTD, 1993年07月, ACTA RADIOLOGICA, 34(4) (4), 399 - 403, 英語
    [査読有り]
    研究論文（学術雑誌）

  • ANGIOMYOLIPOMA OF THE LIVER - ULTRASOUND, CT, MR-IMAGING AND ANGIOGRAPHY
    T MURAKAMI, H NAKAMURA, S HORI, K NAKANISHI, T MITANI, T KOZUKA, Y KIMURA, M MONDEN, K WAKASA, M SAKURAI
    Angiomyolipoma, a rare benign liver tumor, was observed in a 50-year-old woman examined with US, CT, MR imaging and angiography. Dynamic studies using CT and MR imaging were valuable in differentiating the disease from hepatocellular carcinoma with fat deposits.
    MUNKSGAARD INT PUBL LTD, 1993年07月, ACTA RADIOLOGICA, 34(4) (4), 392 - 394, 英語
    [査読有り]
    研究論文（学術雑誌）

  • A case of splenic sarcoidosis
    K. Tsuda, T. Murakami, H. Nakamura, S. Hori, K. Tomoda, T. Mitani, T. Hashimoto, T. Kozuka
    1993年, Japanese Journal of Clinical Radiology, 38(5) (5), 613 - 616, 日本語
    研究論文（学術雑誌）

  • ACALCULOUS CHOLECYSTITIS (PANNICULITIS) ASSOCIATED WITH WEBER-CHRISTIAN DISEASE
    T ISHIDA, H NAKAMURA, S HORI, T MARUKAWA, T MITANI, T MURAKAMI, M NISHIKAWA, K NAKANISHI, S MAESHIMA, M MITOMO, T KOZUKA
    Acalculous cholecystitis occurred in a patient with Weber-Christian disease. It reflected a panniculitis similar to that which developed in the orbit, abdominal cavity, and the retroperitoneal space.
    ELSEVIER SCIENCE INC, 1993年01月, CLINICAL IMAGING, 17(1) (1), 56 - 58, 英語
    [査読有り]
    研究論文（学術雑誌）

  • PELIOSIS OF THE SPLEEN WITH INTRAPERITONEAL HEMORRHAGE
    K TSUDA, H NAKAMURA, T MURAKAMI, T KOZUKA, M YOSHII, K ISOZAKI, Y TSUKAHARA, M TAKAMI, M HANADA
    We encountered a patient with steroid-related peliosis of the spleen, a rare disease characterized by multiple blood-filled cavities in the splenic parenchyma, with spontaneous intraperitoneal hemorrhage. The ultrasonographic, computed tomographic, and angiographic images were compared with pathologic findings of the material obtained surgically.
    SPRINGER VERLAG, 1993年, ABDOMINAL IMAGING, 18(3) (3), 283 - 285, 英語
    [査読有り]
    研究論文（学術雑誌）

  • SUBLUXATION OF THE PATELLA - EVALUATION OF PATELLAR ARTICULAR-CARTILAGE WITH MR IMAGING
    K NAKANISHI, M INOUE, K HARADA, J IKEZOE, T MURAKAMI, H NAKAMURA, T KOZUKA
    In patients with subluxation of the patella, injury of the patellar articular cartilage is frequently observed, and correct evaluation of this cartilage injury is extremely important for the management of these patients. Magnetic Resonance (MR) studies were performed on 102 patellofemoral (PF) joints of 51 patients with subluxation of the patella and 20 PF joints of 10 healthy volunteers. In 77 of the 102 PF joints with subluxation, arthroscopy and/or operation were performed. MR images were obtained with spin-echo and FLASH sequences, and para-axial images were obtained. We retrospectively analysed the MR findings of the 77 joints with special attention to the surface and thickness of the cartilage, and classified them into four grades. These MR grades were compared with the grades on arthroscopy, and the following results were obtained: MR grade 0, normal cartilage (n = 27, sensitivity 90.9%, specificity 74.2%); MR grade 1, thickening of the cartilage (n = 24, sensitivity 50%, specificity 89.1%); MR grade 2, surface irregularity of the cartilage (n = 20, sensitivity 85%, specificity 94.7%); MR grade 3, loss of the cartilage (n = 6, sensitivity 100%, specificity 100%). Although the early changes observed by arthroscopy were underestimated from the MR images, MR imaging proved to be extremely useful for evaluating moderately or advanced patellar cartilage injury.
    BRITISH INST RADIOLOGY, 1992年08月, BRITISH JOURNAL OF RADIOLOGY, 65(776) (776), 662 - 667, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Koh Tokunaga, Hironobu Nakamura, Taro Marukawa, Takashi Mitani, Takamichi Murakami, Masanori Nishikawa, Chikazumi Kuroda, Takahiro Kozuka
    Adrenal venous blood samples drawn before and after stimulation with adrenocorticotropic hormone (ACTH) were analysed in 32 consecutive patients with primary aldosteronism. Twenty-six patients had aldosterone-producing adenomas and six patients had bilateral hyperplasia. The ratio of higher to lower levels of aldosterone in the right and left adrenals (aldosterone ratio), aldosterone to cortisol ratio (A/C ratio), and the ratio of higher to lower levels of A/C ratio in the right and left adrenals (ratio of A/C ratios) were calculated. We used both aldosterone ratio and ratio of A/C ratios as a means of diagnosis, a ratio of 3.0 or more for unilateral adenoma, and less than 3.0 for bilateral hyperplasia. With ACTH stimulation, correct characterization of lesions increased from 91% (29 of 32) to 97% (31 of 32) by aldosterone ratio and from 84% (27 of 32) to 97% (30 of 31) by ratio of A/C ratios. Correct diagnosis of bilateral hyperplasia increased markedly from 67% (4 of 6) to 100% and 50% (3 of 6) to 83% (5 of 6) with use of each criterion. In patients with adenoma, aldosterone ratio rose in 54% (14 of 26) from the pre-stimulation levels. Before stimulation, it ranged from 1.5 to 115.9 (mean 34.8), and afterwards, from 2.1 to 1097.9 (mean 95.5). In contrast, in all patients with bilateral hyperplasia aldosterone ratio fell to less than 3.0 following stimulation with ACTH. With ACTH stimulation, aldosterone ratio increased in patients with adenoma and decreased in patients with hyperplasia. Measurement of A/C ratio is used to ensure correct access to the adrenal veins, but it was useful in only one case and aldosterone ration was a more reliable diagnostic parameter than ratio of A/C ratios in both pre-and post-ACTH stimulations. Assay of aldosterone levels and calculation of aldosterone ratios before and after ACTH stimulation were valuable in locating small adenomas in the right and left adrenal and especially in differentiating bilateral hyperplasia from adenoma. © 1992 Springer-Verlag.
    Springer-Verlag, 1992年05月, European Radiology, 2(3) (3), 223 - 229, 英語
    [査読有り]
    研究論文（学術雑誌）

  • RETROPERITONEAL SCHWANNOMAS SIMULATING ADRENAL-TUMORS
    S MAESHIMA, H NAKAMURA, M NISHIKAWA, T MURAKAMI, T MITANI, T MARUKAWA, S HORI, T KOZUKA, M IRIMOTO
    Tumors in the area of the adrenal were detected by chance in two patients who underwent a regular physical check-up. On arteriography the tumors were found to be fed by the adrenal artery. The diagnosis was retroperitoneal schwannoma, but in both patients it was difficult to differentiate the schwannoma from an adrenal tumor preoperatively.
    ELSEVIER SCIENCE INC, 1992年04月, CLINICAL IMAGING, 16(2) (2), 121 - 124, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Dose finding of epirubicin in transcatheter hepatic chemoembolization
    H. Nakamura, T. Murakami, T. Mitani, K. Nakanishi, S. Hori, T. Kozuka, I. Tsukaguchi, H. Oi, M. Matsushita, T. Hosoki
    1992年, Gan to kagaku ryoho. Cancer & chemotherapy, 19(13) (13), 2271 - 2274, 日本語
    研究論文（学術雑誌）

  • Dynamic MR studies of hepatocellular carcinoma with portal vein tumor thrombosis
    T. Mitani, H. Nakamura, T. Murakami, M. Nishikawa, S. Maeshima, K. Nakanishi, T. Marukawa, K. Harada, S. Hori, T. Kozuka
    1992年, Radiation Medicine - Medical Imaging and Radiation Oncology, 10(6) (6), 232 - 234, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Pancreatic angiography using balloon catheter occlusion and a vasoconstrictor
    H. Nakamura, S. Hori, K. Tomoda, T. Mitani, T. Murakami, T. Hashimoto, K. Nakanishi, S. Maejima, K. Tsuda, T. Kozuka, S. Sawada, S. Furui
    1992年, Radiation Medicine - Medical Imaging and Radiation Oncology, 10(2) (2), 48 - 49, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Stage III, IV hepatocellular carcinoma patients surviving more than five years after transcatheter chemoembolization
    H. Nakamura, T. Mitani, T. Murakami, T. Hashimoto, K. Nakanishi, S. Maeshima, K. Tsuda, K. Tomoda, S. Hori, T. Kozuka, M. Monden, C. Kuroda
    1992年, Japanese Journal of Cancer and Chemotherapy, 19(10) (10), 1756 - 1758, 日本語
    [査読有り]
    研究論文（国際会議プロシーディングス）

  • SIDEROTIC NODULES IN HEPATIC CIRRHOSIS DISAPPEARING AFTER BILIARY HEMORRHAGE - MR IMAGING
    T MURAKAMI, H NAKAMURA, C KURODA, S HORI, T MARUKAWA, T KOZUKA, M MONDEN, K WAKASA
    Magnetic resonance demonstrated siderotic regenerating nodules in a patient with hepatocellular carcinoma with accompanying liver cirrhosis. The siderosis disappeared when iron deficiency anemia developed in association with biliary hemorrhage. Magnetic resonance was sensitive enough to follow changes in the siderosis. The mechanism of iron deposition in regenerating nodules that accompanied liver cirrhosis did not seem to be related to the severity of the liver damage.
    LIPPINCOTT-RAVEN PUBL, 1991年11月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 15(6) (6), 1039 - 1041, 英語
    [査読有り]
    研究論文（学術雑誌）

  • N. Fujita, K. Harada, T. Murakami, Y. Akai, T. Kozuka
    The effects of to‐and‐fro pulsatile flow, i.e., an oscillatory fluid motion with no net flow, on signal intensity in gated spin‐echo magnetic resonance imaging are considered both theoretically and experimentally. On the basis of hydrodynamic principles, to‐and‐fro pulsatile flow at large Womersley numbers consists of uniform inner flow and boundary‐layer‐type flow adjacent to a tube wall. Therefore, the velocity profile is “trapezoidal” rather than parabolic at all times during the pulsation period. Contrary to the absence of phase dispersion and loss of signal within the inner flow where no velocity gradient exists, large velocity differences cause phase dispersion and, hence, loss of signal within the boundary layer, whose thickness is inversely proportional to the Womersley number. An understanding of these features of to‐and‐fro pulsatile flow provides the theoretical basis of cerebrospinal fluid flow phenomena in magnetic resonance imaging, since this type of flow exists in cerebrospinal fluid pathways. © 1990 Academic Press, Inc. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
    1990年, Magnetic Resonance in Medicine, 15(2) (2), 275 - 286, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Cystic adventitial disease of the popliteal artery
    K. Itoh, H. Fukuoka, A. Naitoh, M. Senba, S. Katsuta, Y. Fukuda, K. Dohi, T. Murakami
    1988年, Japanese Journal of Clinical Radiology, 33(10) (10), 1159 - 1161, 日本語
    [査読有り]
    研究論文（学術雑誌）

■ MISC
  • 胸部X線画像のAI診断における診断能の評価について
    北村竜也, 西尾瑞穂, 西尾瑞穂, 池島健吾, 猿丸歩, 村垣善浩, 村上卓道, 保多隆裕
    2024年, 日本生体医工学会大会プログラム・抄録集(Web), 63rd

  • 肥満は腸管内腔グルコース排泄を増強する
    森田靖子, 坂口一彦, 野上宗伸, 野上宗伸, 曽菲比, 西坂まり華, 伊藤潤, 金子景弘, 末松那都, 山田倫子, 山田倫子, 菅原健二, 廣田勇士, 村上卓道, 村上卓道, 小川渉, 小川渉
    2023年, 糖尿病(Web), 66(Suppl) (Suppl)

  • 胸部PET/MRIの減弱補正:高速Zero-TE MRIを用いた深層学習によるノイズ除去および擬似CT生成
    野上宗伸, 野上宗伸, 松尾秀俊, 西尾瑞穂, 立花美保, 井上純子, 曽菲比, 久保和広, 栗本貴子, 村上卓道, 村上卓道
    2023年, 核医学(Web), 60(Supplement) (Supplement)

  • ZTE MRIから2.5次元法深層学習で生成した骨要素を含む減弱補正が胸部領域のSUVに与える影響
    立花美保, 野上宗伸, 野上宗伸, 松尾秀俊, 西尾瑞穂, 井上純子, 曽菲比, 栗本貴子, 久保和広, 村上卓道, 村上卓道
    2023年, 核医学(Web), 60(Supplement) (Supplement)

  • Ⅱ CT：2-3. CTを用いたびまん性肝疾患の診断と定量評価の可能性：特集 肝疾患における画像診断の進歩－腹部超音波, CT, MRI－
    祖父江慶太郎, 村上卓道
    2022年09月01日, 消化器内科, 33(334) (334), 63 - 6368

  • 18 F-FDG PET/MRIを用いた全身画像診断 -PETとDWIBSの比較
    曽菲比, 野上宗伸, 村上卓道
    2022年06月, 臨床画像, 38(6) (6), 86 - 93, 日本語
    [査読有り]

  • 矢部慎二, 祖父江慶太郎, 堀 雅敏, 村上卓道
    インナビネット, 2022年04月, INNERVISION, 37(4) (4), 2 - 5, 日本語, 国内誌

  • 上野嘉子, 祖父江慶太郎, 今岡いずみ, 村上卓道
    子宮頸癌・子宮体癌（内膜癌）においては生検が比較的容易であるため，初回診断時の画像検査は，病理組織学検査で癌が確定した後の進行期分類のために行われるべきである．MRIは，そのコントラストの高さから子宮癌の局所浸潤評価において重要な役割を果たし，近年では，リンパ節転移の評価にFDG-PET/CTの有用性が示されている．婦人科癌の進行期分類には国際産婦人科連合（International Federation of Gynecology and Obstetrics；FIGO）が用いられており，本項ではFIGO分類に基づいた病期診断法について概説する．
    (株)学研メディカル秀潤社, 2022年03月, 画像診断(増刊号), 42(4) (4), S184 - S195, 日本語, 国内誌

  • 祖父江慶太郎, 上嶋英介, 上野嘉子, 村上卓道
    わが国で広く用いられている『臨床・病理 原発性肝癌取扱い規約 第6版補訂版』は2019年1月に第6版補訂版が出版され，国際対がん連合（Union for International Cancer Control；UICC）による『TNM分類 第8版』 との整合性が図られているが，両者の間には少なからず相違が存在する．本稿では『原発性肝癌取扱い規約 第6版補訂版』に準拠しながら，肝細胞癌および肝内胆管癌の画像による病期診断についてCTおよびMRIを中心に概説する．
    (株)学研メディカル秀潤社, 2022年03月, 画像診断(増刊号), 42(4) (4), S106 - S119, 日本語
    [査読有り]

  • 14．子宮：局所進展とリンパ節転移に力点をおいた画像による癌の病期診断
    上野嘉子, 祖父江慶太郎, 今岡いずみ, 村上卓道
    2022年02月28日, 画像診断増刊号, 42(4) (4), S184 - S195, 日本語
    [査読有り]

  • 特集：非B非C型肝癌の治療：6．非B非C型肝癌の治療：（3）肝動脈化学塞栓術
    佐々木康二, 上嶋英介, 岡田卓也, 山口雅人, 杉本幸司, 村上卓道
    日本メディカルセンター, 2022年02月, 臨床消化器内科, 37(3) (3), 304 - 310, 日本語
    [査読有り]

  • 肝癌治療効果判定基準 第6版 2021年度改訂版
    工藤正俊, 池田公史, 上嶋一臣, 坂元亨宇, 椎名秀一朗, 建石良介, 能祖一裕, 長谷川 潔, 古瀬純司, 宮山四朗, 村上卓道, 山下竜也, 國土典宏
    2021年12月, 肝臓(12) (12), 823 - 829

  • 上嶋英介, 祖父江慶太郎, 村上卓道
    「要約」: 肝内胆管癌は, 発育形態により腫瘤形成型, 胆管浸潤型, 胆管内発育型の三つのタイプに分類される一方で, 組織学的には由来となる胆管レベルにより分類される. 2019年に発刊された最新のWHO分類 第5版では, large duct type, small duct typeの二つのタイプに分類され, 本邦の肝癌取扱い規約において単独の疾患として扱われる細胆管癌はsmall duct typeに含まれるようになった. 各タイプにより組織学的特徴や予後が異なり, CTやMRIなどの診断モダリティーによる画像所見も異なる. それぞれに特徴的な所見, 他疾患との鑑別に注意を要すべき所見もあり, これらについて概説する. また, 肝内胆管癌の前癌病変に位置付けられる胆管内乳頭状腫瘍, 肝粘液性嚢胞性腫瘍の画像所見についても併せて述べる.
    2021年09月, 胆と膵, 42(9) (9), 815 - 822

  • 西尾瑞穂, 小林大悟, 松尾秀俊, 西岡瑛子, 浦瀬靖代, 尾上宏治, 石藏礼一, 村上卓道
    2021年07月, 医用画像情報学会雑誌, 38(2) (2), 53 - 56
    [査読有り]

  • 上嶋英介, 祖父江慶太郎, 村上卓道
    Japan Society of Hepatology, 2021年05月01日, 肝臓, 62(5) (5), 229 - 239
    [査読有り]

  • 上野嘉子, 浦瀬靖代, 祖父江慶太郎, 村上卓道
    ＜文献概要＞腎泌尿器領域の正常変異,奇形,腫瘍類似病変を中心に,代表的な画像と診断のポイントについて概説する。
    (株)メジカルビュー社, 2021年04月, 臨床画像増刊号, 37(13) (13), 128 - 150, 日本語

  • 山本雄也, 上野嘉子, 松田耕平, 野上宗伸, 出口雅士, 上原慶一郎, 三木智子, 村上卓道
    金原出版(株), 2021年04月, 臨床画像, 66(4) (4), 381 - 385, 日本語

  • 特集1：地力が伸ばせる腹部画像診断：婦人科・腎・泌尿器：卵巣腫瘍・卵巣茎捻転
    浦瀬靖代, 上野嘉子, 宇野礼奈, 今岡いずみ, 祖父江慶太郎, 村上卓道
    2021年02月, 臨床画像, 37(2) (2), 230 - 244

  • 慢性血栓塞栓性肺高血圧症患者における低侵襲・高精度な肺動脈平均圧の予測モデル作成
    吉井隆浩, 松尾秀俊, 高橋真依, 西尾瑞穂, 河野淳, 谷口悠, 平田健一, 村上卓道
    2021年, 医療情報学連合大会論文集(CD-ROM), 41st

  • 深層学習を用いたZTE MRIによる胸部PET/MRIの吸収補正に関する定量的検証
    野上宗伸, 松尾秀俊, 西尾瑞穂, 曽菲比, 犬養純子, 立花美保, 栗本貴子, 久保和広, 村上卓道, 村上卓道
    2021年, 核医学(Web), 58(Supplement) (Supplement)

  • 非感染性偽関節に対する骨SPECTの定量的評価
    曽菲比, 大江啓介, 野上宗伸, 犬養純子, 立花美保, 久保和広, 福井友章, 新倉隆宏, 黒田良祐, 村上卓道
    2021年, 核医学(Web), 58(Supplement) (Supplement)

  • 肺転移の診断能と融合画像精度におけるZTE併用FDG PET/MRIとPET/CTとの比較
    犬養純子, 野上宗伸, 曽菲比, 立花美保, 久保和広, 栗本貴子, 村上卓道
    2021年, 核医学(Web), 58(Supplement) (Supplement)

  • 50歳代女性に生じ術前診断が困難であった卵巣卵黄嚢腫瘍の一例
    田川純麗, 上野嘉子, 浦瀬靖代, 今岡いずみ, 祖父江慶太郎, 神田知紀, 野上宗伸, 鷲尾佳一, 山崎友維, 寺井義人, 小松正人, 村上卓道
    2021年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging, 22nd (CD-ROM)

  • 当院における内臓動脈瘤に対する血管内治療の経験
    山口雅人, 松永直樹, 佐々木康二, 元津倫幸, 岡田卓也, 杉本幸司, 村上卓道
    2021年, 脈管学(Web), 61(supplement) (supplement)

  • 大学病院における遺伝的アルゴリズムを用いた当直予定表作成システムの開発
    松尾秀俊, 松永卓明, 佐々木康二, 岡田卓也, 西尾瑞穂, 河野淳, 村上卓道
    2021年, 医療情報学連合大会論文集(CD-ROM), 41st

  • 脊髄に発生したdiffuse midline glioma,H3K27M-mutantの3例
    小路田泰之, 神田知紀, 上野嘉子, 西尾瑞穂, 河野淳, 祖父江慶太朗, 野上宗伸, 前田隆樹, 堀雅敏, 村上卓道
    2021年, 日本神経放射線学会プログラム・抄録集, 50th

  • 主治医が求める読影レポートの書き方 泌尿生殖器領域に求められるレポートの書き方
    上野嘉子, 浦瀬靖代, 祖父江慶太郎, 村上卓道
    2021年, 臨床画像, 37(1) (1)

  • 第1回「日本専門医機構」認定放射線科専門医の更新、あるいは移行はどうすればよいですか？
    村上卓道
    2021年01月, 臨床画像, 37(1) (1), 150 - 156

  • 新連載：先生、日本専門医機構認定専門医制度について聞かせてください！
    村上卓道
    2021年01月, 臨床画像, 37(1) (1), 149

  • 子宮内膜癌のMRI
    上野嘉子, 今岡いずみ, 浦瀬靖代, 神田知紀, 祖父江慶太郎, 堀 雅敏, 村上卓道
    2020年11月, 画像診断, 40(13) (13), 1299 - 1310

  • 西岡瑛子, 前田隆樹, 村上卓道
    ＜文献概要＞『急性腹症診療ガイドライン 2015』によると,日本での急性腹症における疾患頻度は診断群分類別包括評価(diagnosis procedure combination;DPC)からは圧倒的に腸管感染症と虫垂炎が多く,急性腹症の場合,腸管感染症・炎症性腸疾患(inflammatory bowel disease;IBD)は常に念頭におくべき疾患である。特に若年者ではこれらの割合が高い。
    (株)メジカルビュー社, 2020年09月, 臨床画像, 36(9) (9), 986 - 995, 日本語

  • 河野 淳, 浦瀬靖代, 渡邊慶明, 村上卓道
    (株)学研メディカル秀潤社, 2020年08月, 画像診断, 40(10) (10), 1141 - 1149, 日本語

  • 浦瀬靖代, 上野嘉子, 神田知紀, 祖父江慶太郎, 小川悟史, 稲場礼奈, 神保直江, 村上卓道
    症例は30歳代男性で、神経線維腫症1型(NF1)で通院中であった。MRIで偶発的に膀胱腫瘤を指摘された。NF1を背景にもち、MRIでの特徴的な信号パターンおよび膀胱鏡で粘膜下腫瘤であったことから、神経線維腫を疑った。根治的切除となると尿路変更術を必要とし、症状がない現状では過大な侵襲であり、かつ切除断端から再発する可能性が高いと考えられ、神経線維腫の診断確定およびmalignant peripheral nerve sheath tumor(MPNST)の除外目的に、三角部の腫瘤よりTUR-BTを施行した。膀胱三角部の腫瘤は容易に切除可能であり、出血もほとんどみられなかった。摘出された腫瘤の組織像では、myxoidな成分を伴う粗な短紡錘形細胞の走行を認め、配列は粗であった。末梢神経に巻き付くように進展する形態を示す部位もみられた。MPNSTを疑うような細胞の異型性はみられなかった。以上より、蔓状神経線維腫と診断された。
    金原出版(株), 2020年05月, 臨床放射線, 65(5) (5), 487 - 490, 日本語

  • 山口 尊, 祖父江慶太郎, 村上卓道
    肝脂肪・肝線維化の評価においては、肝生検による組織学的評価がゴールドスタンダードであるが、その侵襲性の高さから繰り返し評価することが困難であり、サンプリングエラーや病理医間の評価のバラツキも問題となる。そのため近年、画像を用いた非侵襲的な定量的評価法が研究されてきた。一般に、肝脂肪・肝線維化の評価にはMRIが最も正確であるとされるが、検査コストの高さや検査時間の長さが問題となり、超音波検査による評価は再現性の低さや検者間の技術差が弱点となる。CTは、日常臨床で頻用される画像モダリティであり、比較的短時間・低コストで検査を行うことができ、再現性も高いため、びまん性肝疾患の定量評価やフォローアップにおける利用価値が高い。本稿では、CTによる肝脂肪定量・肝線維化推定の実際と今後の展望について概説する。(著者抄録)
    (株)インナービジョン, 2020年04月, INNERVISION, 35(5) (5), 14 - 16, 日本語

  • 外科医が知っておきたい画像診断：5. 肝
    鶴崎正勝, 村上卓道
    2020年04月, 消化器外科, 43(4) (4), 425 - 431

  • 島田隆史, 祖父江慶太郎, 野田知寛, 上田 優, 堀井慎太郎, 曽宮雄一郎, 勝又康友, 日下亜起子, 村上卓道
    上腹部における造影MRI検査では、2008年1月よりガドキセト酸ナトリウム(gadoxetic acid disodium:EOB)の臨床使用が開始されてから、肝臓MRI検査の診断能が大きく向上したのは周知の事実である。しかし、臨床的には注入時間が短いことに起因する撮像タイミングの課題や、動脈相における呼吸性アーチファクト(transient severe motion artifact:TSM)などの問題も確認され、さまざまな対策が試みられている。本稿では、その両者を解決できる可能性のある"4D FreeBreathing"(フィリップス社)が当院に導入されたので、初期経験と問題点を含めて概説する。(著者抄録)
    (株)インナービジョン, 2020年03月, INNERVISION, 35(4) (4), 21 - 24, 日本語

  • 胎児MRIの頭部画像を用いたディープラーニングによる胎児の週数予測
    小路田泰之, 松尾秀俊, 神田知紀, 西尾瑞穂, 河野淳, 祖父江慶太郎, 野上宗伸, 村上卓道
    2020年, 日本神経放射線学会プログラム・抄録集, 49th

  • 悪性腫瘍の全身FDG PET/MRIにおけるBSREMを用いた高速撮像と診断能の検討
    犬養純子, 野上宗伸, 曽菲比, 渡邊慶明, 西尾瑞穂, 神田知紀, 祖父江慶太郎, 河野敦, 久保和広, 村上卓道
    2020年, 核医学(Web), 57(Supplement) (Supplement)

  • 胸部PET/MRIの吸収補正:別症例のCTを用いてZTEから偽CTを深層学習により作成する検討
    野上宗伸, 松尾秀俊, 西尾瑞穂, 曽菲比, 犬養純子, WIESINGER Florian, KAUSHIK Sandeep, 栗本貴子, 久保和広, 村上卓道
    2020年, 核医学(Web), 57(Supplement) (Supplement)

  • マネジメントに苦慮する疾患:Is it benign,malignant or insignificant?6.前立腺clinically insignificant cancerの診断とマネジメントにおけるMRIの役割
    上野嘉子, 玉田勉, 浦瀬靖代, 祖父江慶太郎, 高橋哲, 高橋哲, 村上卓道
    2020年, 日獨医報, 65(1) (1)

  • 曽 菲比, 野上宗伸, 村上 卓道
    2020年01月, 臨床画像, 36(1) (1), 72 - 77

  • 外科医とがん登録―NCDから見えてきたわが国のがん治療の実態―7.肝がん登録
    工藤正俊, 泉 並木, 久保正二, 國土典宏, 坂元亨宇, 椎名秀一朗, 高山忠利, 建石良介, 中島 収, 松山 裕, 村上卓道
    2019年11月01日, 日本外科学会雑誌, 120(6) (6), 663‐670, 日本語

  • 当院における脾動脈瘤に対する動脈塞栓術の治療成績
    岡田 卓也, 佐々木 康二, Hamada Mostafa, 堀之内 宏樹, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本脈管学会, 2019年10月, 脈管学, 59(Suppl.) (Suppl.), S140 - S140, 日本語

  • Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績
    元津 倫幸, 山口 雅人, Hamada Mostafa, 佐々木 康二, 堀之内 宏樹, 上嶋 英介, 岡田 卓也, 祖父江 慶太郎, 後竹 康子, 中井 秀和, 山中 勝弘, 大村 篤史, 岡田 健次, 杉本 幸司, 村上 卓道
    (一社)日本脈管学会, 2019年10月, 脈管学, 59(Suppl.) (Suppl.), S175 - S175, 日本語

  • 気管内挿管後に舌壊死を来した1例
    浦瀬 靖代, 神田 知紀, 小路田 泰之, 上野 嘉子, 祖父江 慶太郎, 前田 隆樹, 野上 宗伸, 村上 卓道
    (公社)日本医学放射線学会, 2019年09月, 日本医学放射線学会秋季臨床大会抄録集, 55回, S558 - S558, 日本語

  • 最新のエビデンスに基づくステントグラフト治療の現況と課題 大動脈解離
    山口 雅人, 岡田 卓也, 元津 倫幸, 佐々木 康二, 堀之内 宏樹, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, 2019年09月, 日本医学放射線学会秋季臨床大会抄録集, 55回, S408 - S408, 日本語

  • 直腸静脈瘤に対して上直腸静脈直接穿刺法で塞栓術を行った1例
    元津 倫幸, 岡田 卓也, 小出 裕, 佐々木 康二, Hamada M.A.S., 堀之内 宏樹, 谷 龍一郎, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2019年09月, 日本インターベンショナルラジオロジー学会雑誌, 34(1) (1), 79 - 79, 日本語

  • 特発性孤立性SMA解離に対するステント留置直後に遠位閉塞をきたした1例
    木下 めぐ美, 川崎 竜太, 丸山 晃司, 清家 翔平, 野村 佳克, 長谷川 翔大, 辻本 貴紀, 松森 正術, 村上 博久, 田中 裕史, 向原 伸彦, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2019年09月, 日本インターベンショナルラジオロジー学会雑誌, 34(1) (1), 81 - 81, 日本語

  • 【エンドリーク】Type II endoleakの制御を目的とした術前塞栓術
    山口 雅人, 元津 倫幸, 佐々木 康二, 岡田 卓也, 小出 裕, 杉本 幸司, 村上 卓道, 後竹 康子, 中井 秀和, 山中 勝弘, 岡田 健次, 林 太郎, 川崎 竜太, 森 岳樹, 魚谷 健祐, 谷口 尚範, 福田 哲也, 宮本 直和, 坂本 憲昭
    (一社)日本インターベンショナルラジオロジー学会, 2019年09月, 日本インターベンショナルラジオロジー学会雑誌, 34(1) (1), 28 - 35, 日本語

  • アミロイド沈着により著明な石灰化を呈した前縦隔リンパ腫の1例
    松尾 秀俊, 岸田 雄治, 神田 知紀, 神保 直江, 伊藤 智雄, 田中 雄悟, 眞庭 謙昌, 村上 卓道
    (公社)日本医学放射線学会, 2019年09月, 日本医学放射線学会秋季臨床大会抄録集, 55回, S550 - S550, 日本語

  • 気管内挿管後に舌壊死を来した1例
    浦瀬 靖代, 神田 知紀, 小路田 泰之, 上野 嘉子, 祖父江 慶太郎, 前田 隆樹, 野上 宗伸, 村上 卓道
    (公社)日本医学放射線学会, 2019年09月, 日本医学放射線学会秋季臨床大会抄録集, 55回, S558 - S558, 日本語

  • 工藤正俊, 泉 並木, 久保正二, 國土典宏, 坂元亨宇, 椎名秀一朗, 高山忠利, 建石良介, 中島 収, 村上卓道, 松山 裕, 田村利恵, 上妻智子
    2019年08月, 肝臓, 60(8) (8), 258 - 293

  • 村上卓道
    2019年08月, 日本磁気共鳴医学会雑誌, 39(3) (3), 72 - 75

  • 特集 転移性肝癌：画像診断
    鶴崎正勝, 村上卓道
    2019年06月, 消化器外科, 42(7) (7), 1025 - 1031

  • 上野嘉子, 浦瀬靖代, 田中宇多留, 神田知紀, 村上卓道
    2019年06月, 画像診断, 39(7) (7), 733 - 744, 日本語

  • 肝細胞癌に対する放射線照射治療後の経動脈的化学塞栓療法の安全性の検討
    小出 裕, ムスタファ・ハマダ, 上嶋 英介, 堀之内 宏樹, 佐々木 康二, 元津 倫幸, 谷 龍一郎, 岡田 卓也, 祖父江 慶太郎, 山口 雅人, 石田 淳, 石原 武明, 佐々木 良平, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 226 - 226, 日本語

  • 当院における経腟分娩後の産道出血に対する動脈塞栓術の検討
    佐々木 康二, 岡田 卓也, HAMADA MOSTAFA, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 239 - 239, 日本語

  • Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績
    元津 倫幸, 山口 雅人, 佐々木 康二, 堀之内 宏樹, 谷 龍一郎, 上嶋 英介, 小出 裕, 岡田 卓也, 祖父江 慶太郎, 後竹 康子, 中井 秀和, 山中 勝弘, 岡田 健次, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 255 - 255, 日本語

  • 当院における大動脈解離に対するTEVARの治療成績
    岡田 卓也, 山口 雅人, 佐々木 康二, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 後竹 康子, 中井 秀和, 山中 勝弘, 岡田 健次, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 259 - 259, 日本語

  • 腸骨動脈慢性閉塞性病変の血管内治療における術前MRIを用いた血栓塞栓性合併症の予測
    丸山 晃司, 川崎 竜太, 木下 めぐ美, 清家 翔平, 岡田 卓也, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 285 - 285, 日本語

  • CTで認識できない骨病変に対するCTガイド下骨生検の検討
    谷 龍一郎, 岡田 卓也, 佐々木 康二, HAMADA MOSTAFA, 堀之内 宏樹, 元津 倫幸, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 314 - 314, 日本語

  • 幼少時の肝外傷が原因と思われる著明なA-Pシャントに対し動脈塞栓術を施行した1例(Hepatic A-P fistula because of remote traumatic liver laceration: report of successful embolization)
    秋田 玄武, 伊崎 健太, 木下 知恵子, 酒井 英郎, 岡田 寛史, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 343 - 343, 英語

  • 肝細胞癌に対する放射線照射治療後の経動脈的化学塞栓療法の安全性の検討
    小出 裕, ムスタファ・ハマダ, 上嶋 英介, 堀之内 宏樹, 佐々木 康二, 元津 倫幸, 谷 龍一郎, 岡田 卓也, 祖父江 慶太郎, 山口 雅人, 石田 淳, 石原 武明, 佐々木 良平, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2019年05月, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 226 - 226, 日本語

  • 香川清澄, 根宜典行, 祖父江慶太郎, 村上卓道
    2019年04月, 臨床画像 - 特集:症候別画像診断プロトコル -, 35(4) (4), 180 - 181, 日本語

  • 祖父江 慶太郎, 上嶋 英介, 上野 嘉子, 岡田 卓也, 山口 雅人, 杉本 幸司, 鶴崎 正勝, 村上 卓道
    ＜文献概要＞Point 1.肝細胞癌の診断において画像診断はきわめて重要な位置を占め,ダイナミックCT・MRIによる血流評価はその基本である.2.肝細胞特異性造影剤(Gd-EOB-DTPA)の臨床導入は,肝細胞癌の診断体系を変化させるほどのインパクトを与えている.
    (株)学研メディカル秀潤社, 2019年04月, 画像診断, 39(6) (6), 623 - 631, 日本語

  • 上野嘉子, 玉田 勉, 高橋 哲, 村上卓道
    2019年04月, 臨床画像, 35(5) (5), 530 - 538, 日本語

  • 皮質病変を認めた非アルコール性Wernicke脳症の1例
    鈴木 絢子, 松木 充, 村上 卓道
    (公社)日本医学放射線学会, 2019年02月, Japanese Journal of Radiology, 37(Suppl.) (Suppl.), 44 - 44, 日本語

  • 肺癌手術にて病理診断されたMultiple minute pulmonary meningothelial-like nodulesの1例
    和田 祐太郎, 松木 充, 土居 秀平, 鈴木 絢子, 沼本 勲男, 小田 晃義, 山田 穣, 兵頭 朋子, 任 誠雲, 甲斐田 勇人, 柳生 行伸, 細川 知紗, 小塚 健倫, 柏木 伸夫, 鶴崎 正勝, 今岡 いずみ, 細野 眞, 石井 一成, 村上 卓道, 榎木 英介
    (公社)日本医学放射線学会, 2019年02月, Japanese Journal of Radiology, 37(Suppl.) (Suppl.), 40 - 40, 日本語

  • 当院における脾動脈瘤に対する動脈塞栓術の治療成績
    岡田卓也, 佐々木康二, HAMADA Mostafa, 堀之内宏樹, 元津倫幸, 上嶋英介, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    2019年, 脈管学(Web), 59(supplement) (supplement)

  • TypeII endoleakの制御を目的とした術前塞栓術
    山口雅人, 元津倫幸, 佐々木康二, 岡田卓也, 小出裕, 杉本幸司, 村上卓道, 後竹康子, 中井秀和, 山中勝弘, 岡田健次, 林太郎, 川崎竜太, 森岳樹, 魚谷健祐, 谷口尚範, 福田哲也, 宮本直和, 坂本憲昭
    2019年, 日本インターベンショナルラジオロジー学会雑誌(Web), 34(1) (1)

  • Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績
    元津倫幸, 山口雅人, HAMADA Mostafa, 佐々木康二, 堀之内宏樹, 上嶋英介, 岡田卓也, 祖父江慶太郎, 後竹康子, 中井秀和, 山中勝弘, 大村篤史, 岡田健次, 杉本幸司, 村上卓道
    2019年, 脈管学(Web), 59(supplement) (supplement)

  • 直腸静脈瘤に対して上直腸静脈直接穿刺法で塞栓術を行った1例
    元津倫幸, 岡田卓也, 小出裕, 佐々木康二, HAMADA M.A.S., 堀之内宏樹, 谷龍一郎, 上嶋英介, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    2019年, 日本インターベンショナルラジオロジー学会雑誌(Web), 34(1) (1)

  • 大動脈解離
    山口雅人, 岡田卓也, 元津倫幸, 佐々木康二, 堀之内宏樹, 杉本幸司, 村上卓道
    2019年, 日本医学放射線学会秋季臨床大会抄録集, 55th

  • 前立腺移行域癌診断におけるQuantitative Multiparametric MRIの有用性
    浦瀬靖代, 上野嘉子, 祖父江慶太郎, 堀井慎太郎, 京谷勉輔, 田中宇多留, 板東由加里, 日向信之, 藤澤正人, 上原慶一郎, 高橋哲, 村上卓道
    2019年, 泌尿器画像診断・治療技術研究会プログラム・抄録, 7th

  • 静脈洞血栓をきたしたRendu‐Osler‐Weber病の一例
    神田知紀, 宮崎亜紀, 曽菲比, 上野嘉子, 祖父江慶太郎, 前田隆樹, 野上宗伸, 村上卓道
    2019年, 日本神経放射線学会プログラム・抄録集, 48th, 101, 日本語

  • 工藤正俊, 池田公史, 上嶋一臣, 坂元亨宇, 椎名秀一朗, 建石良介, 長谷川潔, 古瀬純司, 宮山四朗, 村上卓道, 山下竜也, 國土典宏
    一般社団法人 日本肝臓学会, 2019年01月, 肝臓, 60(2) (2), 55 - 62, 日本語

  • 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    2018年12月, 臨床放射線, 63(12) (12), 122 - 125

  • 肝癌治療のイノベーション－シミュレーション・ナビゲーション技術の新展開－
    鶴﨑正勝, 南 康範, 村上卓道
    2018年12月, 肝胆膵, 77(6) (6), 1199 - 1205

  • 肝動脈塞栓術がTGF-β発現に与える影響 ラット肝癌モデルによる検討
    上嶋 英介, 岡田 卓也, 山口 雅人, 杉本 幸司, 村上 卓道, 西尾福 英之, 田中 利洋, 吉川 公彦, 高木 治行, 児玉 大志, 山門 亨一郎
    (一社)日本インターベンショナルラジオロジー学会, 2018年11月, IVR: Interventional Radiology, 33(3) (3), 317 - 317, 日本語

  • 破裂性十二指腸静脈瘤に対してバルーン閉塞下逆行性静脈瘤塞栓術を施行した1例
    小出 裕, 岡田 卓也, 佐々木 康二, 元津 倫幸, Hamada M.A.S., 谷 龍一郎, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2018年11月, IVR: Interventional Radiology, 33(3) (3), 317 - 318, 日本語

  • 【救急IVR手技詳説 with WEB動画】手技詳説 非血管IVR 画像ガイド下穿刺 超音波ガイド下穿刺
    祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    金原出版(株), 2018年11月, 臨床放射線, 63(12) (12), 1582 - 1585, 日本語
    [招待有り]
    記事・総説・解説・論説等（学術雑誌）

  • 【救急IVR手技詳説 with WEB動画】手技詳説 血管IVR 胸部 胸部大動脈損傷
    山口 雅人, 丸山 晃司, 杉本 幸司, 村上 卓道, 森 岳樹, 築部 卓郎
    金原出版(株), 2018年11月, 臨床放射線, 63(12) (12), 1392 - 1395, 日本語
    記事・総説・解説・論説等（学術雑誌）

  • FDG PET/MRにおける呼吸同期下MR吸収補正と画像再構成法の影響
    野上 宗伸, 曽 菲比, 若林 雄一, 上野 嘉子, 神田 知紀, 祖父江 慶太郎, 栗本 貴子, 久保 和広, 村上 卓道
    (一社)日本核医学会, 2018年11月, 核医学, 55(Suppl.) (Suppl.), S209 - S209, 英語

  • PET/CTと1.5Tおよび3T PET/MRIにおける非小細胞肺癌の臨床病期診断脳に関する比較検討
    大野 良治, 青柳 康太, 油井 正生, 岸田 雄治, 関 紳一郎, 吉川 武, 野上 宗伸, 村上 卓道
    (一社)日本核医学会, 2018年11月, 核医学, 55(Suppl.) (Suppl.), S202 - S202, 英語

  • 山口雅人, 丸山晃司, 杉本幸司, 村上卓道, 森 岳樹, 築部卓郎
    2018年11月, 臨床放射線, 63(12) (12), 122 - 125, 日本語

  • 頭頸部癌による急性出血に対する動脈塞栓術の検討
    小出 裕, 岡田 卓也, 佐々木 康二, 元津 倫幸, 谷 龍一郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本救急医学会, 2018年10月, 日本救急医学会雑誌, 29(10) (10), 464 - 464, 日本語

  • Four-dimensional CT(4DCT)による咀嚼時の下顎頭前方滑走の解析
    関谷 俊範, 明石 昌也, 筧 康正, 根宜 典行, 西尾 卓郎, 星野 貴志, 櫻井 玲, 泉谷 信行, 日下 亜起子, 古森 孝英, 村上 卓道
    (公社)日本診療放射線技師会, 2018年09月, JART: 日本診療放射線技師会誌, 65(9) (9), 1011 - 1011, 日本語

  • 中長期成績からみた腹部大動脈瘤ステントグラフトの功罪 IMA閉塞例におけるEVAR後のType 2エンドリークの検討 予防的IMA塞栓術は有用か?
    岡田 卓也, 元津 倫幸, 山口 雅人, 佐々木 康二, Hamada Mostafa, 谷 龍一郎, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 杉本 幸司, 村上 卓道, 後竹 康子, 中井 秀和, 山中 勝弘, 田中 裕史
    (一社)日本脈管学会, 2018年09月, 脈管学, 58(Suppl.) (Suppl.), S107 - S107, 日本語

  • 翼口蓋窩に生じた筋上皮腫の1例
    立花 美保, 神田 知紀, 田中 宇多留, 上野 嘉子, 祖父江 慶太郎, 前田 隆樹, 野上 宗伸, 村上 卓道, 神澤 真紀, 伊藤 智雄
    (公社)日本医学放射線学会, 2018年09月, 日本医学放射線学会秋季臨床大会抄録集, 54回, S536 - S536, 日本語

  • IVRの進歩がどのように門脈圧亢進症の治療を変えたのか? 肝細胞癌門脈腫瘍栓に対するEMS留置術
    鶴崎 正勝, 沼本 勲男, 小田 晃義, 門場 智也, 柳生 行伸, 祖父江 慶太郎, 杉本 幸司, 村上 卓道
    (一社)日本門脈圧亢進症学会, 2018年08月, 日本門脈圧亢進症学会雑誌, 24(3) (3), 86 - 86, 日本語

  • 兵頭朋子, 矢田典久, 前西 修, 松木 充, 村上卓道
    1 CT値とは 2 線維化 2.1 びまん性の肝線維化 2.2 限局性の線維化 3 脂肪化 3.1 びまん性の肝脂肪化 3.2 肝脂肪定量の方法論 3.3 限局性の脂肪化 3.4 Dual-energy CT 4 CTイメージングの多様化と注意点
    (一社)日本肝臓学会, 2018年08月, 肝臓, 59(8) (8), 393 - 406, 日本語
    [招待有り]

  • 鶴崎正勝, 祖父江慶太郎, 村上卓道
    2018年05月, 臨牀消化器内科, 3(6) (6), 599 - 604, 日本語

  • 鈴木 絢子, 沼本 勲男, 松木 充, 小田 晃義, 柳生 行伸, 小塚 健倫, 石井 一成, 榎木 英介, 村上 卓道
    78歳男。腹部鈍痛を主訴とした。近医にて血液検査で炎症反応高値、汎血球減少、ALP上昇、肝機能障害、腎機能障害を認めた。腹部骨盤CTでは体腔液貯留、肝・副腎腫大、椎体・仙骨・腸骨・大腿骨の骨髄濃度の上昇を認め、腎盂腎炎疑いで4週間加療するも発熱と腹水増加を呈した。紹介受診時には体温38℃で、血液生化学検査所見の改善はみられなかった。胸部・腹部骨盤CTでは胸腹水増加、全身浮腫増悪、全身の多発リンパ腫大を認めた。骨髄生検では原発性骨髄線維症grade MF1相当であった。鼠径リンパ節生検ではhyaline-vascular typeのCastleman病類似の組織像を認めた。TAFRO症候群と診断した。
    金原出版(株), 2018年05月, 臨床放射線, 63(5) (5), 553 - 557, 日本語

  • バッドキアリ症候群に伴う急性肝不全に対して肝移植までのbridging therapyとしてTIPSを施行した1例
    沼本勲男, 鶴崎正勝, 小田晃義, 柳生行伸, 鈴木絢子, 土居秀平, 柏木伸夫, 村上卓道, 上嶋一臣, 工藤正俊
    (一社)日本インターベンショナルラジオロジー学会, 2018年05月01日, IVR, 33(1) (1), 67 - 67, 日本語

  • 渡邊 翔太, 坂口 健太, 細野 眞, 石井 一成, 村上 卓道, 市川 勝弘

    The purpose of this study was to evaluate the effect of a hybrid-type iterative reconstruction method on Z-score mapping of hyperacute stroke in unenhanced computed tomography (CT) images. We used a hybrid-type iterative reconstruction [adaptive statistical iterative reconstruction (ASiR)] implemented in a CT system (Optima CT660 Pro advance, GE Healthcare). With 15 normal brain cases, we reconstructed CT images with a filtered back projection (FBP) and ASiR with a blending factor of 100% (ASiR100%). Two standardized normal brain data were created from normal databases of FBP images (FBP-NDB) and ASiR100% images (ASiR-NDB), and standard deviation (SD) values in basal ganglia were measured. The Z-score mapping was performed for 12 hyperacute stroke cases by using FBP-NDB and ASiR-NDB, and compared Z-score value on hyperacute stroke area and normal area between FBP-NDB and ASiR-NDB. By using ASiR-NDB, the SD value of standardized brain was decreased by 16%. The Z-score value of ASiR-NDB on hyperacute stroke area was significantly higher than FBP-NDB (p<0.05). Therefore, the use of images reconstructed with ASiR100% for Z-score mapping had potential to improve the accuracy of Z-score mapping.

    公益社団法人 日本放射線技術学会, 2018年04月, 日本放射線技術学会雑誌, 74(4) (4), 375 - 381, 日本語
    [査読有り]

  • 孤立性内臓動脈解離のCT所見
    福井秀行, 松木充, 任誠雲, 甲斐田勇人, 柳生行伸, 小塚健倫, 細川知紗, 熊野正士, 柏木伸夫, 鶴崎正勝, 今岡いずみ, 細野眞, 石井一成, 村上卓道
    2018年02月25日, Japanese Journal of Radiology, 36(Supplement) (Supplement), 34, 日本語

  • IVR後の画像診断 Ch. 5 金属コイルを用いた動脈塞栓術後の画像診断
    岡田卓也, 曽宮雄一郎, 香川清澄, 前林知樹, Hamada M.A, S, 佐々木康二, 元津倫幸, 谷 龍一郎, 上嶋英介, 小出 裕, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    2018年02月, IVR会誌, 33, 137 - 143, 日本語

  • 神経核内封入体病の1例
    沼本 勲男, 松木 充, 福井 秀行, 若林 雄一, 日高 正二郎, 渡口 真史, 藤谷 哲也, 山川 美帆, 兵頭 朋子, 山田 穣, 任 誠雲, 甲斐田 勇人, 柳生 行伸, 柏木 伸夫, 細川 知紗, 小塚 健倫, 鶴崎 正勝, 今岡 いずみ, 細野 眞, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, 2018年02月, Japanese Journal of Radiology, 36(Suppl.) (Suppl.), 27 - 27, 日本語
    [査読有り]

  • Ⅱ．肝癌の診断：ダイナミックCT・MRI
    祖父江慶太郎, 鶴﨑正勝, 村上卓道
    2018年02月, 日本臨床, 76(2) (2), 211 - 217

  • 胎児臍帯ヘルニア破裂の一例
    西岡瑛子, 上野嘉子, 谷村憲司, 森実真由美, 山田秀人, 大片祐一, 尾藤祐子, 村上卓道
    2018年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging, 19th

  • IMA閉塞例におけるEVAR後のType2エンドリークの検討:予防的IMA塞栓術は有用か?
    岡田卓也, 元津倫幸, 山口雅人, 佐々木康二, HAMADA Mostafa, 谷龍一郎, 上嶋英介, 小出裕, 祖父江慶太郎, 杉本幸司, 村上卓道, 後竹康子, 中井秀和, 山中勝弘, 田中裕史
    2018年, 脈管学(Web), 58(supplement) (supplement)

  • 低侵襲手術に対応する病期診断
    高橋哲, 上野嘉子, 古川順也, 日向信之, 寺川智章, 藤澤正人, 村上卓道
    2018年, 泌尿器画像診断・治療技術研究会プログラム・抄録, 6th, 27, 日本語

  • 腎腫瘍のFDG‐PET:画像と病理所見の対比
    上野嘉子, 野上宗伸, 高橋哲, 高橋哲, 山崎隆, 山崎隆, 寺川智章, 日向信之, 田中宇多留, 藤澤正人, 伊藤智雄, 村上卓道
    2018年, 泌尿器画像診断・治療技術研究会プログラム・抄録, 6th, 51, 日本語

  • Hepatic Guideの有用性. 特集「肝癌治療のイノベーション-シミュレーション・ナビゲーション技術の新展開-」
    南 知宏, 南 康範, 工藤正俊, 鶴﨑正勝, 柳生行伸, 村上卓道
    2018年, 肝胆膵, 77, 1161 - 1165, 日本語
    [査読有り]

  • 特集 肝癌診療A to Z：2．肝癌画像診断のアップデート：CT，MRI
    鶴﨑正勝, 祖父江慶太郎, 村上卓道
    2017年10月, 肝癌クリニカルアップデート, 3(2) (2), 115

  • 動態に基づいたアミロイドイメージング雑音除去アルゴリズムの性能評価
    山田 誉大, 木村 裕一, 藤井 康介, 渡辺 翔吾, 永岡 隆, 花岡 宏平, 細川 知紗, 石井 一成, 村上 卓道
    (一社)日本核医学会, 2017年09月, 核医学, 54(Suppl.) (Suppl.), S210 - S210, 日本語

  • 呼吸同期FDG PET/CTによる放射線治療計画について
    花岡 宏平, 奥村 雅彦, 西村 泰昌, 門前 一, 渡邊 翔太, 柴田 侑亮, 細野 眞, 石井 一成, 村上 卓道
    (一社)日本核医学会, 2017年09月, 核医学, 54(Suppl.) (Suppl.), S167 - S167, 日本語

  • 動態に基づいたアミロイドイメージング雑音除去アルゴリズムの性能評価
    山田 誉大, 木村 裕一, 藤井 康介, 渡辺 翔吾, 永岡 隆, 花岡 宏平, 細川 知紗, 石井 一成, 村上 卓道
    (一社)日本核医学会, 2017年09月, 核医学, 54(Suppl.) (Suppl.), S210 - S210, 日本語

  • 呼吸同期FDG PET/CTによる放射線治療計画について
    花岡 宏平, 奥村 雅彦, 西村 泰昌, 門前 一, 渡邊 翔太, 柴田 侑亮, 細野 眞, 石井 一成, 村上 卓道
    (一社)日本核医学会, 2017年09月, 核医学, 54(Suppl.) (Suppl.), S167 - S167, 日本語

  • 画像診断のイノベーションー診断・治療のアプローチをどう変えたか
    村上卓道
    2017年09月, CLINICIAN, 64(9) (9), 82 - 89

  • Prognostic impact of F-18-FDG PET parameters and molecular markers expression in resected non-small cell lung cancer patients.
    Hayato Kaida, Koichi Azuma, Akihiko Kawahara, Eiji Sadashima, Satoshi Hattori, Jun Akiba, Axel Rominger, Shinzo Takamori, Kiminori Fujimoto, Makoto Hosono, Kazunari Ishii, Takamichi Murakami, Masatoshi Ishibashi
    SOC NUCLEAR MEDICINE INC, 2017年05月, JOURNAL OF NUCLEAR MEDICINE, 58, 英語
    研究発表ペーパー・要旨（国際会議）

  • MRI diffusion imageを用いたADC値とシクロスポリン腎症の検討
    宮崎 紘平, 杉本 圭相, 宮沢 朋生, 塩谷 拓嗣, 岡田 満, 村上 卓道, 竹村 司
    (一社)日本小児腎臓病学会, 2017年05月, 日本小児腎臓病学会雑誌, 30(1Suppl.) (1Suppl.), 208 - 208, 日本語

  • 宮崎 紘平, 杉本 圭相, 宮沢 朋生, 塩谷 拓嗣, 岡田 満, 村上 卓道, 竹村 司
    (一社)日本小児腎臓病学会, 2017年05月, 日本小児腎臓病学会雑誌, 30(1Suppl.) (1Suppl.), 208 - 208, 日本語

  • 【動脈・静脈の疾患(上)-最新の診断・治療動向-】動脈・静脈疾患の検査 動脈疾患の検査 動脈疾患のCT
    河野 淳, 鶴崎 正勝, 杉本 幸司, 村上 卓道
    (株)日本臨床社, 2017年05月, 日本臨床, 75(増刊4 動脈・静脈の疾患(上)) (増刊4 動脈・静脈の疾患(上)), 160 - 165, 日本語

  • X線の性質を応用した新しい検査手法：医療用デュアルエネルギーX線CTの最近の技術
    村上卓道
    2017年05月, 非破壊検査, 66(5) (5), 217 - 221

  • 祖父江 慶太郎, 村上 卓道, 鶴崎 正勝, 山口 雅人, 杉本 幸司, 杉村 和朗
    金原出版(株), 2017年04月, 臨床放射線, 62(4) (4), 497 - 505, 日本語
    [招待有り]
    記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）

  • FDG-PET/CTで集積を認めた異所性甲状腺癌の一例
    甲斐田 勇人, 石井 一成, 細川 知紗, 仁 誠雲, 細野 眞, 村上 卓道, 花岡 宏平, 乾 浩己
    (一社)日本核医学会, 2017年02月, 核医学, 54(1) (1), 668 - 669, 日本語

  • FDG-PET/CTで集積を認めた異所性甲状腺癌の一例
    甲斐田 勇人, 石井 一成, 細川 知紗, 仁 誠雲, 細野 眞, 村上 卓道, 花岡 宏平, 乾 浩己
    (一社)日本核医学会, 2017年02月, 核医学, 54(1) (1), 668 - 669, 日本語

  • 【Multi-Organ Disease-臓器からアプローチする全身疾患-】肝胆膵 変性・代謝性疾患
    祖父江 慶太郎, 鶴崎 正勝, 村上 卓道, 丸山 晃司, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 栄介, 岡田 卓也, 山口 雅人, 杉本 幸司, 杉村 和朗
    金原出版(株), 2016年11月, 臨床放射線, 61(11) (11), 1439 - 1443, 日本語
    記事・総説・解説・論説等（学術雑誌）

  • 肺動静脈瘻の存在診断、IVR治療後の効果判定にに経頭蓋ドプラーエコー検査が有用であった一例
    沼本 勲男, 鶴崎 正勝, 小田 晃義, 日高 正二朗, 朝戸 信行, 任 誠雲, 柳生 行伸, 松木 充, 大槻 俊輔, 村上 卓道
    (一社)日本脈管学会, 2016年10月, 脈管学, 56(Suppl.) (Suppl.), S239 - S239, 日本語

  • 経カテーテル動脈塞栓術を施行した腹部内臓動脈瘤の4例
    朝戸信行, 高橋一肇, 足利竜一朗, 沼本勲男, 柳生行伸, 鶴崎正勝, 村上卓道
    (一社)日本脈管学会, 2016年10月, 脈管学(Web), 56(supplement) (supplement), S212‐S213(J‐STAGE) - S213, 日本語

  • 認知症患者における線条体アミロイド沈着の検討
    細川 知紗, 石井 一成, Sauerbeck Julia, Sheiwein Franziska, 甲斐田 勇人, 兵頭 朋子, 山田 穣, 細野 眞, 花岡 宏平, 村上 卓道
    (一社)日本核医学会, 2016年10月, 核医学, 53(Suppl.) (Suppl.), S276 - S276, 日本語

  • DP-CAR(腹腔動脈合併尾側膵切除術)前にAmplatzer Vascular Plugを用いて総肝動脈塞栓を行った4症例
    渡口 真史, 鶴崎 正勝, 沼本 勲男, 日高 正二朗, 朝戸 信行, 山川 美帆, 任 誠雲, 柳生 行伸, 松木 充, 竹山 宜典, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2016年04月, IVR: Interventional Radiology, 31(Suppl.) (Suppl.), 248 - 248, 日本語

  • 祖父江慶太郎, 鶴崎正勝, 村上卓道, 上田優, 奥秋知幸, 杉村和朗
    造影ダイナミックMRIは、実質臓器の解剖や血流を詳細に把握できると同時に、腫瘤性病変の血行動態を評価することが可能である。近年、肝臓を対象とした造影MRI検査では、肝特異性造影剤であるGd-EOB-DTPAを用いたダイナミックスタディが一般的である。Gd-EOB-DTPAは、投与量の約50%は通常の細胞外液性造影剤と同様に腎臓から排泄され、残りの50%は肝細胞に取り込まれた後に胆汁に排泄される特性を有しており、細胞外液性造影剤と同様のダイナミックスタディによる血流診断能と、高い腫瘍-肝コントラストを誇る肝細胞相による病変の検出能向上が同時に実現されている。一方で、Gd-EOB-DTPA造影剤の規定投与量は従来の細胞外液性造影剤の1/2と少ないため、動脈相における最適撮像タイミングの設定が難しく、超高速撮像法の有用性が示唆されている。本稿では、Gd-EOB-DTPAを用いた造影MRI動脈相撮像における特徴を述べた後に、view sharingを用いた超高速撮像法による動脈相の多時相撮像について解説する。(著者抄録)
    (株)インナービジョン, 2016年04月, INNERVISION, 31(5号) (5号), 60 - 61, 日本語
    [招待有り]
    記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）

  • 鶴崎正勝, 村上卓道, 祖父江慶太郎
    (株)インナービジョン, 2016年04月, INNERVISION, 31(5号) (5号), 2 - 5, 日本語
    [招待有り]
    記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）

  • 【これだけは知っておきたいCT/MRIの基本:研修医の必須知識】腫瘍性病変 肝・胆・膵
    祖父江 慶太郎, 岡田 卓也, 山口 雅人, 杉本 幸司, 杉村 和朗, 鶴崎 正勝, 村上 卓道
    (株)メジカルビュー社, 2016年04月, 臨床画像, 32(4月増刊) (4月増刊), 186 - 195, 日本語
    [招待有り]
    記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）

  • HCCに対するDEB-TACE時に発生したVascular lakeの検討
    沼本 勲男, 鶴崎 正勝, 渡口 真史, 日高 正二朗, 山川 美帆, 任 誠雲, 柳生 行伸, 村上 卓道, 田北 雅弘, 萩原 智, 南 康範, 上嶋 一臣, 西田 直生志, 工藤 正俊, 朝戸 信行
    (一社)日本インターベンショナルラジオロジー学会, 2016年04月, IVR: Interventional Radiology, 31(Suppl.) (Suppl.), 156 - 156, 日本語

  • 当院における大腸内視鏡不完全症例に対するCT colonographyの活用
    松木充, 朝戸信行, 山川美帆, 藤谷哲也, 任誠雲, 兵頭朋子, 柳生行伸, 鶴崎正勝, 熊野正士, 今岡いずみ, 足利竜一朗, 石井一成, 村上卓道
    (公社)日本医学放射線学会, 2016年02月25日, Japanese Journal of Radiology, 34(Supplement) (Supplement), 57 - 57, 日本語

  • 細川 知紗, 石井 一成, Sauerbeck Julia, Scheiwein Franziska, 甲斐田 勇人, 山田 穣, 兵頭 朋子, 細野 眞, 花岡 宏平, 村上 卓道
    (一社)日本核医学会, 2016年02月, 核医学, 53(1) (1), 561 - 561, 日本語

  • 広範な骨盤内浸潤を伴った子宮内膜症の一例
    小田晃義, 松木充, 今岡いずみ, 沼本勲男, 福井秀行, 日高正二郎, 兵頭朋子, 小谷泰史, 任誠雲, 柳生行伸, 柏木伸夫, 小塚健倫, 鶴崎正勝, 万代昌紀, 村上卓道
    2016年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging, 17th

  • 薬剤動態に基づいたアミロイドイメージングに対する雑音低減アルゴリズム
    木村裕一, 藤井康介, 山田誉大, 細川知紗, 坂田宗之, 石井一成, 村上卓道
    2016年, 核医学(Web), 53(Supplement) (Supplement)

  • 肺動静脈瘻の存在診断,IVR治療後の効果判定に経頭蓋ドプラーエコー検査が有用であった一例
    沼本勲男, 鶴崎正勝, 小田晃義, 日高正二朗, 朝戸信行, 任誠雲, 柳生行伸, 松木充, 大槻俊輔, 村上卓道
    2016年, 脈管学(Web), 56(supplement) (supplement), S239(J‐STAGE), 日本語

  • 認知症患者における線条体アミロイド沈着の検討
    細川知紗, 石井一成, SAUERBECK Julia, SHEIWEIN Franziska, 甲斐田勇人, 兵頭朋子, 山田穣, 細野眞, 花岡宏平, 村上卓道
    2016年, 核医学(Web), 53(Supplement) (Supplement), 1230(J‐STAGE), 日本語

  • 11C‐PiB PET陽性認知症の線条体集積の検討
    細川知紗, 石井一成, SAUERBECK Julia, SCHEIWEIN Franziska, 甲斐田勇人, 山田穣, 兵頭朋子, 細野眞, 花岡宏平, 村上卓道
    2016年, 核医学(Web), 53(1) (1), 561(J‐STAGE), 日本語

  • 石井一成, 細川知紗, 兵頭朋子, 坂口健太, 宇佐美公男, 島元健次, 細野眞, 山添穰, 村上卓道
    2016年, 臨床核医学, 49(6) (6), 89 - 90, 日本語
    [査読有り]

  • 診断のための基本知識：画像診断：
    今岡いずみ, 福井秀行, 村上卓道
    2015年12月, 癌診療指針のための病理診断プラクティス 婦人科腫瘍, 10 - 18
    [査読有り]

  • Introducing the Glucose Metabolism to Amyloid Deposition Ratio Image
    K. Ishii, R. Takahashi, Y. Wakabyashi, C. Hosokawa, H. Kaida, T. Murakami
    SPRINGER, 2015年10月, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 42, S546 - S546, 英語
    研究発表ペーパー・要旨（国際会議）

  • The correlation of dual phase F-18-FDG PET/CT to immunohistochemical prognostic factors in breast cancer patients
    Hayato Kaida, Uhi Toh, Akihiko Kawahara, Seiji Kurata, Yasumitsu Hirose, Masayoshi Kage, Kazunari Ishii, Takamichi Murakami, Masatoshi Ishibashi
    SOC NUCLEAR MEDICINE INC, 2015年05月, JOURNAL OF NUCLEAR MEDICINE, 56(3) (3), 英語
    研究発表ペーパー・要旨（国際会議）

  • Increased Pittsburgh Compound B accumulation in the regional white matters of Alzheimer brain
    Yuichi Wakabayashi, Kazunari Ishii, Chisa Hosokawa, Tomoko Hyodo, Takenori Kozuka, Takamichi Murakami, Kazuro Sugimura
    SOC NUCLEAR MEDICINE INC, 2015年05月, JOURNAL OF NUCLEAR MEDICINE, 56(3) (3), 英語
    研究発表ペーパー・要旨（国際会議）

  • Dual energy CTの現状と展望－次世代の標準的CTに向けて－肝・胆・膵
    鶴崎正勝, 村上卓道
    2015年04月, 臨床画像, 31(4) (4), 483 - 489
    [査読有り]

  • 後縦隔に発生したectopic neural tissueの1例
    朝戸信行, 松木充, 福井秀行, 藤谷哲也, 任誠雲, 千葉輝明, 高橋洋人, 兵頭朋子, 山田稔, 柳生行伸, 鶴崎正勝, 岡田真広, 柏木伸夫, 細川知紗, 小塚健倫, 今岡いずみ, 足利竜一朗, 石井一成, 村上卓道
    (公社)日本医学放射線学会, 2015年02月25日, Jpn J Radiol, 33(Supplement) (Supplement), 77 - 77, 日本語

  • Gd-EOB-DTPA造影剤を用いたMRIによる肝機能評価の試み
    勝部 敬, 北垣 一, 村上卓道
    2015年02月, G.I.Research, 23(2) (2), 58 - 64
    [査読有り]

  • どのようなときにGd-EOB-DTPA造影MRIを行うか
    工藤正俊, 今井康陽, 村上卓道
    2015年, 肝癌診療マニュアル 第3版, 日本肝臓学会編集, 医学書院, 東京, 47 - 50, 日本語
    [査読有り][招待有り]

  • Cone-beam CT angiography（tracking navitation imagingも含めて）
    南 康範, 村上卓道, 工藤正俊
    2015年, 最新肝癌学, 73, 579 - 581, 日本語
    [査読有り]

  • 画像診断 CT:Dual energy CT
    鶴﨑正勝, 村上卓道
    2015年01月, 日本臨床 最新肝癌学－基礎と臨床の最新研究動向－, 73(1) (1), 513 - 518

  • Flight Plan for Liverを用いたTACE
    柳生行伸, 鶴﨑正勝, 南 康範, 工藤正俊, 村上卓道
    2015年01月, 肝胆膵, 70(1) (1), 15 - 23

  • 工藤正俊, 上嶋一臣, 久保正二, 坂元享宇, 田中正俊, 猪飼伊和夫, 古瀬純司, 村上卓道, 角谷眞澄, 國土典宏
    2015年01月, 肝臓, 56(3) (3), 116 - 121, 日本語

  • 腹部のCT
    松木 充, 村上卓道
    2014年10月, 消化器病診療（第2版）, 290 - 292

  • 鑑別を要する多血性病変：画像診断のポイント
    鶴﨑正勝, 村上卓道
    2014年09月, Hepatology Practice5 肝癌の診療を極める－基本から最前線まで－, 107 - 113

  • 出血を繰り返した腹壁静脈門脈短絡に対して直接穿刺による硬化療法を施行した一例
    鶴崎正勝, 朝戸信行, 沼本勲男, 渡口真史, 山川美帆, 任誠雲, 柳生行伸, 村上卓道
    2014年08月31日, 日本門脈圧こう進症学会雑誌, 20(3) (3), 101, 日本語

  • シェーマで納得!基礎から学べるCT/MRI腹部画像診断に役立つサイン 肝・脾
    松木充, 沼本勲男, 福井秀行, 若林雄一, 渡口真史, 朝戸信行, 山川美帆, 兵頭朋子, 柳生行伸, 熊野正士, 鶴崎正勝, 村上卓道, 東山央, 稲田悠紀
    2014年08月26日, 臨床画像, 30(8) (8), 828 - 839, 日本語

  • 松木 充, 沼本 勲男, 福井 秀行, 若林 雄一, 渡口 真史, 朝戸 信行, 山川 美帆, 兵頭 朋子, 今岡 いずみ, 鶴崎 正勝, 村上 卓道, 東山 央, 稲田 悠紀
    (株)学研メディカル秀潤社, 2014年08月, 画像診断, 34(10) (10), 1205 - 1216, 日本語

  • 吉川秀司, 岡田真広, 近藤浩史, 曺 博信, 村上卓道, 兼松雅之, 市川智章, 早川晶子, 塩境一仁, 栗井和夫, 吉満研吾, 山下康行
    2014年08月, 日本放射線技術学会雑誌, 70(8) (8), 805 - 813

  • 肝動脈化学塞栓療法
    鶴﨑正勝, 村上卓道
    2014年08月, 外科, 76(8) (8), 864 - 869

  • Comparison between SUV and BP images acquired using 11C-PIB PET: Questionable PIB accumulation in SUV images
    Chisa Hosokawa, Kazunari Ishii, Yuichi Kimura, Kenta Sakaguchi, Makoto Hosono, Takamichi Murakami
    SOC NUCLEAR MEDICINE INC, 2014年05月, JOURNAL OF NUCLEAR MEDICINE, 55, 英語
    研究発表ペーパー・要旨（国際会議）

  • 頭蓋底の画像診断
    柏木伸夫, 村上卓道
    2014年05月, 臨床放射線, 59(5) (5), 657 - 677

  • Value of EUS in early detection of pancreatic ductal adenocarcinomas in patients with intraductal papillary mucinous neoplasms. (vol 46, pg 22, 2014)
    Ken Kamata, Masayuki Kitano, Masatoshi Kudo, Hiroki Sakamoto, Kumpei Kadosaka, Takeshi Miyata, Hajime Imai, Kiyoshi Maekawa, Takaaki Chikugo, Masashi Kumano, Tomoko Hyodo, Takamichi Murakami, Yasutaka Chiba, Yoshifumi Takeyama
    GEORG THIEME VERLAG KG, 2014年04月, ENDOSCOPY, 46(4) (4), 358 - 358, 英語
    その他

  • 肝臓病理に画像診断はどこまで迫れたか Dual energy CTを用いた肝脂肪変性定量評価の有用性 肝生検標本を用いた脂肪変性定量との比較
    倉橋 知英, 澤井 良之, 福田 和人, 井倉 技, 小来田 幸世, 今井 康陽, 磯谷 圭介, 米澤 稔, 藤田 典彦, 兵頭 朋子, 辻川 華子, 阿部 時也, 橋口 明典, 坂本 亨宇, 村上 卓道
    (一社)日本肝臓学会, 2014年04月, 肝臓, 55(Suppl.1) (Suppl.1), A128 - A128, 日本語

  • 肝動脈化学塞栓療法(TACE)不応の肝細胞癌に対するソラフェニブの効果
    村上 卓道, 山門 亨一郎, 宮山 士朗, 狩野 光伸
    (株)ライフ・サイエンス, 2014年03月, Progress in Medicine, 34(3) (3), 455 - 461, 日本語

  • plain cone-beam CTによる肝動脈塞栓術の定量的治療効果予測
    南 康範, 南 知宏, 有住 忠晃, 田北 雅弘, 北井 聡, 矢田 典久, 井上 達夫, 萩原 智, 上嶋 一臣, 西田 直生志, 工藤 正俊, 柳生 行伸, 村上 卓道
    (一財)日本消化器病学会, 2014年03月, 日本消化器病学会雑誌, 111(臨増総会) (臨増総会), A275 - A275, 日本語

  • 画像診断ガイドライン-知っておきたいポイント- 消化器-肝癌-
    村上卓道
    2014年03月, 臨床放射線, 59(3) (3), 413 - 421

  • 画像をめぐるコミュニケーションの問題
    足利竜一朗, 村上卓道
    2013年11月, 臨床画像, 29(11) (11), 1336 - 1339

  • 肝脂肪変性の非侵襲的な定量評価におけるDual energy CTの有用性の検討
    倉橋 知英, 今井 康陽, 澤井 良之, 福田 和人, 井倉 技, 小来田 幸世, 磯谷 圭介, 米澤 稔, 藤田 典彦, 工藤 正幸, 兵頭 朋子, 岡田 真広, 村上 卓道
    (一社)日本肝臓学会, 2013年11月, 肝臓, 54(Suppl.3) (Suppl.3), A798 - A798, 日本語

  • Gd‐EOB‐DTPA造影MRIをさらに深く知る 9.Gd‐EOB‐DTPA造影MRIによる転移性肝腫瘍の検出と鑑別
    鶴崎正勝, 兵頭朋子, IM Sung‐Woom, 岡田真広, 松木充, 足利竜一朗, 石井一成, 村上卓道
    2013年11月, 日獨医報, 58(2) (2), 203 - 211, 日本語

  • 黄疸
    鶴﨑正勝, 村上卓道
    2013年10月, 臨床画像, 29(10) (10), 160 - 167

  • 門脈圧亢進症の血行動態 十二指腸静脈瘤におけるMD-CTを用いた経カテーテル的治療術前の血行動態の把握とその有用性
    鶴崎 正勝, 中村 友則, 朝戸 信行, 任 誠雲, 柳生 行伸, 杉本 幸司, 村上 卓道
    2013年08月, 日本門脈圧亢進症学会雑誌, 19(3号) (3号), 78, 日本語

  • 自然縮小を来した頸部デスモイド腫瘍の1例
    松久保祐子, 村上卓道, 柏木伸夫, 佐藤隆夫, 足利竜一朗, 細野 眞, 森 一功, 土井勝美
    2013年03月, 臨床放射線, 58(3) (3), 459 - 462

  • 肝癌の早期発見 CT,MRI検査
    今井康陽, 村上卓道, 金 東石, 永野浩昭
    2013年02月, 臨牀と研究, 90(2) (2), 64 - 69

  • 子宮体癌リンパ節術後再発による消化管出血に対してcovered stent留置およびコイル塞栓術を行った1例
    柳生 行伸, 任 誠雲, 日高 正二朗, 荒木 哲朗, 足利 竜一朗, 村上 卓道, 中井 英勝, 飛梅 孝子
    (一社)日本インターベンショナルラジオロジー学会, 2013年02月, IVR: Interventional Radiology, 28(1) (1), 108 - 108, 日本語

  • 3D Arterial spin labelingによるアルツハイマー病の脳灌流画像 SPECTとの比較(Brain perfusion imaging of Alzheimer's disease with 3D arterial spin labeling: Comparison with brain perfusion SPECT)
    高橋 洋人, 石井 一成, 柏木 伸夫, 宮越 敬三, 花岡 宏平, 村上 卓道
    (公社)日本医学放射線学会, 2013年02月, 日本医学放射線学会学術集会抄録集, 72回, S282 - S282, 英語

  • Gd-EOB-DTPA造影MRIによる転移性肝腫瘍の検出と鑑別
    鶴﨑正勝, 兵頭朋子, 任 誠雲, 岡田真広, 松木 充, 足利竜一朗, 石井一成, 村上卓道
    2013年02月, 日獨医報, 58(2) (2), 66 - 74

  • 肝腫瘍のDual Energy Imaging
    河野雄輝, 村上卓道, 上村正信, 宇都辰郎, 岡田真広, 兵頭朋子, 鶴﨑正勝, 松木 充
    2013年01月, 映像情報Medical, 45(1) (1), 20 - 25

  • 言語課題における「難易度」と脳賦活領域:fMRIによる検討
    岡田理恵子, 中野直樹, 宮内正晴, 石井一成, 村上卓道, 大槻俊輔, 加藤天美
    2013年, 日本ヒト脳機能マッピング学会プログラム・抄録集, 15th, 84, 日本語

  • 血管侵襲の診断：血管造影を施行しない場合
    柳生行伸, 村上卓道
    2013年, 診療ガイドラインに沿った肝癌治療の要点と盲点, 41 - 43

  • Ｖ診断法・画像診断
    柏木伸夫, 村上卓道
    2013年, 肩こりの臨床, 136 - 143

  • EOB-MRIの早期肝癌と異型結節（DN)の識別診断能：EOB-MRIによる早期肝癌の診断能：生検標本との対比：
    今井康陽, 村上卓道
    2013年, EOB-MRI/Sonazoid超音波による肝癌の診断と治療, 131 - 137

  • EOB-MRI/Sonazoid超音波による肝癌の診断と治療
    岡田真広, 村上卓道
    2013年, EOB-MRI/Sonazoid超音波による肝癌の診断と治療, 59 - 65

  • EOB-MRIの基本的知識：最適な撮像法：Philips
    村上卓道, 岡田真広
    2013年, EOB-MRI/Sonazoid超音波による肝癌の診断と治療, 37 - 45

  • MRI応用自在：MRガイド下集束超音波療法（MR-GUIDED FUS)
    村上卓道
    2013年, Medical View, 225 - 226

  • 肝細胞癌のすべて2012 肝癌の診断アルゴリズム コンセンサスに基づく診療ガイドライン
    今井康陽, 小来田幸世, 高村学, 大西裕満, 金東石, 永野浩昭, 岡田真広, 村上卓道
    2012年12月28日, 肝胆膵, 65(6) (6), 1171 - 1179, 日本語

  • Gd-EOB-DTPA造影MRIにおけるLook-Lockerシーケンスを用いたMR relaxometry
    小野田 農, 村上卓道, 岡田真広, 兵頭朋子, 松木 充, 石井一成, 宇都辰郎
    2012年12月, 臨床画像, 28(12) (12), 1444 - 1451

  • 消化救急疾患の画像診断 消化管閉塞－3. 絞扼性腸閉塞－
    松木 充, 日高正二朗, 任 誠雲, 兵頭朋子, 山田 穣, 柳生行伸, 鶴崎正勝, 岡田真広, 細川知紗, 小塚健倫, 今岡いずみ, 村上卓道
    2012年12月, 画像診断, 32(14) (14), 1417 - 1418

  • CT診断
    岡田真広, 村上卓道
    金芳堂, 2012年11月, 放射線医学消化器画像診断・IVR, 84 - 97

  • MRI診断
    岡田真広, 村上卓道
    2012年11月, 放射線医学消化器画像診断・IVR, 98 - 109

  • レビー小体型認知症の頭頂側頭連合野の代謝低下はアミロイド沈着によらない
    石井一成, 兵頭朋子, 坂口健太, 花岡宏平, 宇佐美公男, 島元健次, 山添譲, 山田穣, 松木充, 細野眞, 村上卓道
    2012年11月, 核医学, 49(4) (4), 435, 日本語

  • Detection of Small Concomitant Carcinomas Distinct From Intraductal Papillary Mucinous Neoplasms Under the Surveillance of the Whole Pancreas Using EUS
    K. Kamata, M. Kitano, M. Kudo, H. Sakamoto, K. Kadosaka, T. Miyata, H. Imai, T. Komaki, K. Maekawa, T. Chikugo, M. Kumano, T. Hyodo, T. Murakami, Y. Takeyama
    LIPPINCOTT WILLIAMS & WILKINS, 2012年10月, PANCREAS, 41(7) (7), 1143 - 1143, 英語
    研究発表ペーパー・要旨（国際会議）

  • 近畿大学医学部放射線医学教室放射線診断学部門主任教授 村上卓道氏インタビュー 更なる高速化と低被ばく化に長足の進歩を遂げた高性能CTは、病院のプレゼンスを高める格好の"武器"です (総特集 高性能CTが約束する病院の"発信力")
    村上 卓道
    エム・イー振興協会 ; 1975-, 2012年10月, 月刊新医療, 39(10) (10), 28 - 31, 日本語

  • Dual energy CTにおけるCT値精度の検証
    霜村康平, 河野雄輝, 浅井義行, 奥村雅彦, 松本賢治, 西村恭昌, 兵頭朋子, 村上卓道, 荒木不次男
    2012年09月13日, 医学物理 Supplement, 32(3) (3), 147 - 148, 日本語

  • 〈原著〉ダイナミックマルチスライスCTにおける多血性肝細胞癌検出に最適な造影剤量の検討
    藤谷 哲也, 熊野 正士, 村上 卓道
    [抄録] (目的)64チャンネルマルチスライスCT（MDCT）を用いた肝臓ダイナミックスタディーにおける，肝細胞癌検出のための最適な造影剤量を前向きに検討する． (対象と方法) 対象は肝細胞癌（HCC）が既知又は疑われ，64列MDCTでダイナミックMDCTを施行した128例である．このうち36名が合計56結節の多血性HCCを罹患していた． 63名の患者に525mgヨード/kg（mgI/kg）の造影剤が用いられ（プロトコールＡ），62名の患者に630mgI/kgの造影剤が用いられた（プロトコールＢ）． 造影剤の注入時間は30秒とした． 動脈相，門脈相，平衡相，各相における腹部大動脈，門脈，肝静脈，肝実質とHCCのCT値を計測した．HCCの計測値から肝実質の計測値を引いた値を腫瘍-肝実質コントラスト（TLC）と定義し，プロトコールＡ，Ｂの間で比較した． 統計的分析はMann-Whitney U testを用いた． なお，この研究は，臨床試験審査委員会の承認と患者の同意が得られている． (結果) 大動脈の動脈相，門脈相，平衡相，各相におけるCT値は，プロトコールＡでそれぞれ313，153，120HU，プロトコールＢでそれぞれ351，166，132HUであり，すべての相において，大動脈の造影効果はプロトコールＢの方がＡより有意に高かった（P＜0.01）． 門脈の各相におけるCT値は，プロトコールＡでそれぞれ146，167，122HU，プロトコールＢで163，190，136HUであり，すべての相において，門脈のCT値はプロトコールＢの方がＡより高かった（P＝0.023，P＜0.001，P＜0.001）．肝静脈の各相におけるCT値は，プロトコールＡでそれぞれ124，112，111HU，プロトコールＢで126，139，124HUであり，門脈相，平衡相ともに，肝静脈のCT値は有意にプロトコールＢの方が高かった（P＜0.001）． 肝実質の各相におけるCT値は，プロトコールＡで77，112，100HU，プロトコールＢで82，121，108HUであり，肝実質の造影値は門脈相，平衡相で有意にプロトコールＢの方が高かった（P＜0.001）． TLCの各相における値はプロトコールＡで28.0，－9.8，－12.1HU，プロトコールＢで37.4，－11.8，－13.6HUであり，TLCは動脈相でプロトコールＢの方が有意に高かった（P＝0.042）． (結論)630mgI/kg量の造影剤投与の方が，525mgI/kgよりも動脈相における多血性HCCの肝臓とのコントラストをより向上させた． また，平衡相において50HU以上の十分な肝実質造影を呈した．
    近畿大学医学会, 2012年09月, 近畿大学医学雑誌, 37(3) (3), 155 - 162, 日本語

  • 認知症における脳FDG‐PET早期撮像の可能性について
    兵頭朋子, 石井一成, 坂口健太, 花岡宏平, 宇佐美公男, 島元健次, 山添譲, 山田穣, 松木充, 細野眞, 村上卓道
    2012年08月31日, 核医学, 49(3) (3), 294, 日本語

  • 腹腔鏡下大腸癌手術のための3D-CT angiography (特集 消化管画像診断 : 最近のトピックス)
    松木 充, 村上 卓道
    金原出版, 2012年08月, 臨床放射線, 57(8) (8), 1037 - 1044, 日本語

  • 肝細胞癌治療の現状と画像診断 肝細胞癌の治療効果判定基準(criteria)の比較
    岡田真広, 兵頭朋子, 村上卓道
    2012年07月25日, 画像診断, 32(9) (9), 882 - 888, 日本語

  • 進行肝癌の診断：画像診断
    鶴﨑正勝, 村上卓道
    2012年06月, 肝胆膵, 65(6) (6), 1085 - 1092

  • TACEにおけるインターベンション支援アプリケーションの臨床的有用性
    栁生行伸, 村上卓道
    2012年05月, Innervison, 27(5) (5), 66 - 70

  • MR relaxometryによる慢性肝障害診断-EOB造影とSPIO造影MRIを用いた肝機能評価の有用性
    岡田真広, 兵頭朋子, 村上卓道
    2012年05月, Innervison Innervison, 27(5) (5), 22 - 25

  • EOB-MRI:CTAP,SPIO-MRIとの比較
    今井康陽, 村上卓道, 岡田真広, 小来田幸世, 高村 学, 大西裕満, 金 東石
    2012年04月, 肝胆膵画像, 14(4) (4), 330 - 338

  • 兵頭朋子, 岡田真広, 香川祐毅, 今井康陽, 望月輝一, 工藤正俊, 村上卓道
    2012年04月, 肝胆膵画像, 14(4) (4), 365 - 368

  • 今井康陽, 高村学, 大西裕満, KIM T, 岡田真広, 村上卓道
    2012年03月01日, 内科, 109(3) (3), 408 - 413, 日本語

  • 131I甲状腺内用療法におけるSPECT/CTを用いた甲状腺重量測定について
    花岡宏平, 大塚正和, 吉田修平, 井上亮, 石井一成, 村上卓道, 細野眞
    2012年02月29日, 日本放射線技術学会総会学術大会予稿集, 68th, 185-186, 日本語

  • X-rayイメージングのNext Innovation-Dual Energy CTの臨床
    兵頭朋子, 村上卓道
    2012年02月, 日獨医放, 57(2) (2), 177 - 191

  • 18F-FDG PET/CTにてsuperscanを呈した腎癌骨転移の1例
    兵頭 朋子, 石井 一成, 細野 眞, 阪本 祐一, 米矢 吉宏, 柳生 行伸, 土屋 典生, 熊野 正士, 足利 竜一朗, 中村 一郎, 植村 天受, 村上 卓道
    (一社)日本核医学会, 2011年11月, 核医学, 48(4) (4), 471 - 471, 日本語

  • ASSESSMENT OF HEPATOBILIARY PHASE GD-EOB-DTPA-ENHANCED MRI FOR HCC AND DYSPLASTIC NODULES AND COMPARISON OF DETECTION ABILITY VERSUS MDCT
    Tatsuo Inoue, Masatoshi Kudo, Arizumi Tadaaki, Sousuke Hayaishi, Masahiro Takita, Satoshi Kitai, Norihisa Yada, Satoru Hagiwara, Yasunori Minami, Kazuomi Ueshima, Masahiro Okada, Hyodo Tomoko, Takamichi Murakami
    WILEY-BLACKWELL, 2011年10月, HEPATOLOGY, 54, 899A - 899A, 英語
    研究発表ペーパー・要旨（国際会議）

  • 肝－肝組織特異性MR造影剤を用いた肝機能MR診断を中心に
    村上卓道, 岡田真広
    2011年09月, Innervison, 26(9) (9), 11 - 14

  • Innova4100の最新IVR支援機能の使用経験と将来展望－マルチモダリティイメージングのIVRへの応用
    村上卓道
    2011年07月, Innervison, 26(7) (7), 90 - 92

  • 今井康陽, 小来田幸世, 井倉 技, 澤井良之, 大濱日出子, 福田和人, 関 康, 高村 学, 岡田真広, 村上卓道
    近年，multidetector-row CT（MDCT），MRIの撮像高速化などの各種画像機器の技術開発は著しく，加えて超音波造影剤ペルフルブタン・Sonazoid®，MRI造影剤Gd-EOB-DTPAの新しい肝特異性造影剤の登場により，形態，血流面からだけでなく，肝網内系や肝細胞機能からも診断が可能となり，肝細胞癌の非侵襲的な画像診断法は飛躍的に進歩した．また，Volume navigation®，Real time virtual sonography®などのmultimodality fusion imagingも肝細胞癌の診断，治療支援に有用性が高い．このように多様化した各診断法の特性を理解し，相補的に組み合わせて肝細胞癌の診断を行うことが重要である．
    The Japanese Society of Gastroenterology, 2011年06月, 日本消化器病学会雑誌, 108(6) (6), 916 - 927, 日本語

  • 肝癌に対するCT・MRI診断-CTAPは必要か？-
    村上卓道, 岡田真広, 兵頭朋子, 今井康陽
    2011年05月, 外科治療, 105(5) (5), 443 - 452

  • Assessment of Hepatobilliary Phase Gd-EOB-DTPA-Enhanced MRI for HCC and Borderline Lesions and Comparison of Detection Ability Versus MDCT
    Tatsuo Inoue, Masatoshi Kudo, Mina Komuta, Michiie Sakamoto, Masahiro Okada, Takamichi Murakami
    W B SAUNDERS CO-ELSEVIER INC, 2011年05月, GASTROENTEROLOGY, 140(5) (5), S920 - S920, 英語
    研究発表ペーパー・要旨（国際会議）

  • EOB造影MRI肝細胞相のみで同定し得た乏血性高分化型肝細胞癌―Volume Navigationを用いた診断と治療
    大濱日出子, 井倉技, 今井康陽, 福田和人, 澤井良之, 小来田幸世, 土本雄亮, 牧野祐紀, 水本塁, 宇都宮大輔, 岩崎哲也, 中松大, 松本康史, 中原征則, 厨子慎一郎, 黒川正典, 関康, 高村学, 竹内真, 村上卓道
    (一財)日本消化器病学会, 2011年03月15日, 日本消化器病学会雑誌, 108(臨増総会) (臨増総会), A322 - A322, 日本語

  • 転移性肝腫瘍診断における有用性
    朝戸信行, 岡田真弘, 熊野正士, 藤谷哲也, 柳生行伸, 柏木伸夫, 小塚健倫, 今岡いずみ, 足利竜一朗, 石井一成, 村上卓道
    2011年03月, 臨床画像, 27(3) (3), 342 - 347

  • 〈原著〉高速多相性CT撮像を用いた多血性肝細胞癌の最適な撮像時間の検討
    香川 祐毅, 岡田 真広, 柳生 行伸, 熊野 正士, 石井 一成, 村上 卓道
    [抄録] 肝細胞癌の画像診断において，肝ダイナミックCTは必須の検査である．肝ダイナミックCT検査では，一般に造影前，動脈相，門脈相，平衡相を撮像することが多く，多血性肝細胞癌の診断のためには，動脈相の早期濃染をとらえることが最も重要である．本検討で我々は，多血性肝細胞癌患者25症例43結節に対して，64列マルチスライスCTを用いた高速多相撮像（volume helical shuttle；VHS）による肝ダイナミック撮像を行い，動脈相の最適なタイミングを調べた．撮像プロトコールは，ヨード系造影剤（600mgl/kg）を注入時間一定（30秒）で静脈内投与し，bolus tracking法を利用して造影剤が肝臓レベルの腹部大動脈に到達してから6秒後より，全肝を2秒撮像で，計12相（6往復）撮像した．得られた12相の動脈相画像の大動脈，門脈，肝実質，肝細胞癌にviewer画面上で関心領域を置き，time density curve（TDC）を作成した．造影剤到達から多血性肝細胞癌と肝実質のコントラストが最も高くなるタイミング，すなわち腫瘍/肝実質コントラスト（tumor-liver contrast；TLC）が最大となる時間とその最大値を計測した．結果であるが，TLCの最大値は35.6Hounsfield unit（HU）で大動脈への造影剤到達から約21秒後に認めた．多血性肝細胞癌を診断する際には，動脈相における早期濃染を最適な条件下で撮像することが重要であり，そのタイミングとして大動脈への造影剤到達後21秒で撮像するのが肝要と考えられた．
    近畿大学医学会, 2011年03月, 近畿大学医学雑誌, 36(1) (1), 19 - 24, 日本語

  • MDCTが術前に有用であった仮性胸部大動脈瘤の1例
    中内祥文, 岩永善高, 小夫家和宏, 金田敏夫, 西野貴子, 佐賀俊彦, 村上卓道, 宮崎俊一
    2011年02月15日, 日独医報, 55(3/4) (3/4), 319, 日本語

  • 加藤里枝子, 今岡いずみ, 岡田真広, 村上卓道, 栗生明博
    25歳女。不正出血を主訴とした。MRIで骨盤内に脂肪を含んだだるま型の腫瘤を認め、その腹側に不整形の充実性腫瘍が存在していた。充実性腫瘍はT1強調像で低信号、T2強調像で高信号、内部樹枝状の低信号を示し、乳頭状に発育していた。造影CTでは充実性腫瘍が淡い増強効果を示し、複数の腹膜播種を疑う病変もあり、上皮性癌または境界悪性腫瘍を疑い、切除術を施行した。右卵巣に脂肪を含むだるま型の腫瘤の間に充実性腫瘍を認め、一部漿膜が破綻し、露出して体網が癒着していた。病理組織所見で、だるま型腫瘤は角化重層扁平上皮に囲まれたcystがあり、壁に皮膚付属器や軟骨組織を認め、成熟嚢胞性奇形腫と診断した。これとは別に大小不同の濃染核をもつ円柱状の異型細胞が繊毛状或いは乳頭腺管状に配列して増殖・浸潤しており、卵巣漿液性腺癌と診断した。二つの組織は近接していたが移行像は認めず、collision tumorと考えられた。
    金原出版(株), 2011年, 臨床放射線, 56(13) (13), 1833 - 1836, 日本語

  • 消化器疾患の画像診断の進歩Perfusion CT 消化器疾患の最新医療
    村上卓道, 岡田真広
    2011年, 先端医療シリーズ, 42, 295 - 298

  • 各種造影剤の種類と用法（X線検査，CT，MRI，US）
    村上卓道, 岡田真広
    2011年, 放射線医学 放射線医学総論, 1, 82 - 91

  • 分子標的治療薬導入後の肝細胞癌治療戦略－放射線科医の立場から－
    松井 修, 荒井保明, 村上卓道, 宮山士朗, 稲葉吉隆, 池田公史
    2011年, 新薬と臨床, 60, 11 - 27
    [査読有り]

  • Iterative reconstruction CT
    村上卓道, 岡田真広, 今岡いずみ, 工藤正幸
    2011年01月, 映像情報Medical, 43(1) (1), 28 - 31

  • 岡田真広, 香川祐毅, 熊野正士, 柳生行伸, 任誠雲, 今岡いずみ, 足利竜一朗, 石井一成, 山田浩司, 工藤正幸, 工藤正俊, 村上卓道
    2011年01月, 肝胆膵画像, 13(1) (1), 37 - 44

  • Clinical Challenge
    香川祐毅, 岡田真広, 村上卓道
    2011年01月, 肝胆膵画像, 13(1) (1), 6 - 7

  • 肝臓画像診断の進歩
    岡田真広, 村上卓道, 今井康陽
    2011年, Annual Review 2011消化器, 189 - 194

  • 肝特異性造影剤と多段階発癌
    今井康陽, 村上卓道
    2011年01月, The LIVER CANCER JOURNAL, 3(1) (1), 6 - 14

  • 〈原著〉64列多列化CTを用いた新しい定量的心筋灌流イメージング法
    中内 祥文, 岩永 善高, 生田 新一郎, 工藤 正幸, 村上 卓道, 宮崎 俊一
    [抄録] 目的：コンピューター断層撮影（CT）と逆積分解析法を用いた定量的な組織灌流定量的評価法が心筋灌流分析に適用できるかは不明である．今回，我々は64列多列化CTと逆積分法を用いて算出した定量的心筋灌流イメージング法の評価を行った． 方法：正常例10例と急性心筋梗塞（AMI）患者19例で組織血流量（TBF），組織血液量（TBV），平均通過時間（MTT）の３つの灌流指標を逆積分解析によって算出し，single photon emission computed tomography（SPECT）像を含む臨床指標との比較を行った． 結果：正常例における左心室心筋のTBFは，128.44±20.79ml/100g/minであり，従来の報告と近似していた．AMI患者では，梗塞領域のTBFとTBVは非梗塞領域より有意に低値であった（p＜0.01）．梗塞領域のMTTは，非梗塞領域より延長していた（p＜0.01）．TBVカラーマップにおける血流低下領域の面積は，血清クレアチンキナーゼピーク値，QRSスコア，SPECT欠損スコアと有意な正の相関を示した（p＜0.05）．TBFの心外膜側/心内膜側比は，側副血行路が発達した群で乏しい群に比較して有意に高値であった（p＜0.01）． 結論：AMI患者における心筋灌流異常を，当方法を用いて初めて定量的に検出できた．当方法はAMIの臨床評価に有用であることが示唆された．
    近畿大学医学会, 2010年12月, 近畿大学医学雑誌, 35(3) (3), 167 - 175, 日本語

  • 〈原著〉三次元CT画像を用いた冠動脈の起始異常および開口部起始位置の解剖学的調査
    工藤 正幸, 村上 卓道, 中内 祥文, 宮崎 俊一, 重吉 康史
    [抄録]近年，冠動脈病変の評価において，マルチスライスCT（MDCT）による心電図同期再構成法を用いた冠動脈の血管撮影の有用性が確立されてきている．冠動脈の走行状態や起始分岐異常分類に関する研究は多いが，起始位置の幾何学的な形態調査研究は少ない．本研究はMDCTによって得られた三次元画像を用い，邦人の冠動脈起始異常の発現率およびその分岐形態の幾何学的情報についての解剖学的調査研究である．分岐異常を有した症例は1,053例中，高位起始症例が0例，左前下行枝と左回旋枝が分離して起始する症例が８例（0.755％），右冠動脈が左冠尖から分岐する症例が６例（0.570％）の合計14例（1.330％）認められた．正常分岐症例の評価における冠動脈の分岐角度は，左冠動脈に比べ右冠動脈が有意に鈍角で，左右冠動脈間の分離角度は139.9°±17.3離れて分岐しており，男女間では有意差は無かった．Valsalva洞底部から冠動脈起始部までの距離は，左冠動脈（10.84±2.80mm）に比べ右冠動脈（11.94±3.05mm）の方が有意に高い位置で分岐し，男女間では左右冠動脈とも男性の方が高い位置で分岐していた．三次元画像による冠動脈の起始位置の形態評価で，冠動脈の起始の形態は個人差が大きいことが判明し，本邦におけるデータベースを構築できた．これは今後，冠動脈形成術施行時の術前評価や解剖教育などに貢献できる．
    近畿大学医学会, 2010年12月, 近畿大学医学雑誌, 35(3) (3), 177 - 184, 日本語

  • 当施設での国産FPD biplane装置の使用経験
    布川知史, 中川修宏, 辻潔, 植嶋利文, 木村貴明, 畠中剛久, 内山卓也, 上田傑, 橋場久幸, 坂田育弘, 加藤天美, 村上卓道
    (NPO)日本脳神経血管内治療学会, 2010年11月01日, J Neuroendovascular Ther, 4(4) (4), 384 - 384, 日本語

  • 肝細胞癌に対する最近のMDCT診断
    熊野正士, 岡田真広, 村上卓道, 工藤正幸
    2010年10月, Pharma Medica Pharma Medica, 28(10) (10), 19 - 22

  • 早期肝細胞癌と異型結節の鑑別におけるEOB造影MRIの有用性
    今井康陽, 村上 卓道, 岡田 真広, 大西裕満
    2010年10月, Pharma Medica Pharma Medica, 28(10) (10), 23 - 27

  • EOB・プリモビスト造影MRI―肝機能評価への可能性―(肝臓のEOB・プリモビスト造影MRI―本検査を有効に活用するための理解すべき課題 7)
    岡田真広, 勝部敬, 香川祐毅, 兵頭朋子, 熊野正士, 今岡いずみ, 石井一成, 今井康陽, 工藤正俊, 村上卓道
    2010年09月, 日獨医報, 55(2) (2), 179 - 186, 日本語

  • Gd-EOB-DTPA造影MRIの臨床的インパクト
    岡田 真広, 今井 康陽, 村上 卓道
    2010年08月15日, 日本磁気共鳴医学会雑誌, 30(3) (3), 100 - 109, 日本語

  • 村上 卓道
    近年，超音波（US）検査では造影剤を用いた肝腫瘍の検査法が進歩した．マルチスライスCT（MDCT）では空間・時間分解能が向上し，3次元画像に動態情報（時間軸）が加わった4次元画像が登場してきている．MRIは，Gd-EOB-DTPAなどの肝組織特異性造影剤が臨床応用され，肝腫瘍の診断能が向上した．PET-CT検査は，全身CTでとらえた病変の代謝情報から悪性度を評価でき，手術適応の決定や治療効果判定に利用されている．血管造影では，cone-beam CT装置による3次元血管造影が精度の高いIVR治療に貢献している．それぞれの検査法の特徴をよく理解した上で，最適な検査法をうまく組み合わせた総合画像診断（マルチモダリティー）を行うことが重要である．
    The Japanese Society of Gastroenterology, 2010年05月05日, 日本消化器病學會雜誌 = The Japanese journal of gastro-enterology, 107(5) (5), 693 - 702, 日本語

  • 肝癌の診断 肝癌スクリーニングにおける画像診断 －Gd-EOB-DTPA 造影MRIを中心に
    今井康陽, 村上卓道, 岡田真広
    日本メディカルセンテアー, 2010年05月, 臨床消化器内科, 25(4) (4), 423 - 436

  • EOB造影MRIによる多血性肝細胞癌診断におけるsubtraction画像の有用性
    土本雄亮, 今井康陽, 香川祐毅, 岡田真広, 橋本博美, 小来田幸世, 澤井良之, 井倉技, 福田和人, 松本康史, 中原征則, 厨子慎一郎, 黒川正典, 丸川太郎, 高村学, 村上卓道
    (一社)日本肝臓学会, 2010年04月30日, 肝臓, 51(Supplement 1) (Supplement 1), A201 - A201, 日本語

  • 肝細胞癌におけるEOB造影MRI肝細胞相の造影効果―組織分化度および門脈血流との対比
    小来田幸世, 今井康陽, 土本雄亮, 福田和人, 井倉技, 澤井良之, 黒川正典, 高村学, 丸川太朗, 大西裕満, 堀雅敏, 金東石, 岡田真広, 村上卓道
    (一社)日本肝臓学会, 2010年04月30日, 肝臓, 51(Supplement 1) (Supplement 1), A196 - A196, 日本語

  • EOB造影MRIによる多血性肝細胞癌診断におけるsubtraction画像の有用性
    土本雄亮, 今井康陽, 香川祐毅, 岡田真広, 橋本博美, 小来田幸世, 澤井良之, 井倉技, 福田和人, 黒川正典, 高村学, 村上卓道
    (一財)日本消化器病学会, 2010年03月15日, 日本消化器病学会雑誌, 107(臨増総会) (臨増総会), A304 - A304, 日本語

  • 熊野正士, 岡田真広, 村上卓道
    2010年, 肝胆膵画像, 12(5) (5), 585 - 591

  • 肝がん(肝細胞がん)の診断・治療におけるアルゴリズム－ソナゾイド造影USとEOB造影MRIを中心に
    今井康陽, 岡田真広, 村上卓道, 関 康
    2010年, INNERVISION, 25(5) (5), 9 - 12

  • 肝画像診断におけるCT PerfusionとVolume Helical Shuttleの有用性
    岡田真広, 香川祐毅, 村上卓道, 工藤正幸
    2010年, 映像情報Medical, 42, 266 - 271

  • マルチモダリティによるAbdominai Imaging
    村上卓道
    2010年, INNERVISION INNERVISION, 25(4) (4), 2 - 6

  • 拡散強調像において広範な大脳高信号を呈したShaken baby syndromeの2例
    朝戸信行, 香川祐毅, 村上卓道
    2010年, 臨床放射線, 55(4) (4), 553 - 557

  • MRIでPeritoneal inclusion cystの長期経過を追った1例
    加藤里枝子, 香川祐毅, 今岡いずみ, 村上卓道
    2010年, 臨床放射線, 55(7) (7), 919 - 923

  • 64列MDCTを用いた心筋血流イメージングの定量分析
    中内祥文, 岩永善高, 生田新一郎, 村上卓道, 宮崎俊一
    2009年11月25日, 日本冠疾患学会雑誌, 15(4) (4), 350, 日本語

  • Quantitative Analysis of Myocardial Perfusion Imaging by Using 64 Channels Multi Detector-row Computed Tomography
    Yoshifumi Nakauchi, Shinichiro Ikuta, Masayuki Kudo, Takamichi Murakami, Shunichi Miyazaki
    LIPPINCOTT WILLIAMS & WILKINS, 2009年11月, CIRCULATION, 120(18) (18), S374 - S374, 英語
    研究発表ペーパー・要旨（国際会議）

  • 私が期待する4次元MDCT診断と心臓CT検査 (特集 だから私は、このモダリティに期待する)
    村上 卓道
    エム・イ-振興協会, 2009年08月, 月刊新医療, 36(8) (8), 80 - 83, 日本語

  • Assessment of lymph node metastasis esophageal cancer with SUV correction based on count recovery on 18F-FDG PET/CT
    Yoshihiro Komeya, Makoto Hosono, Norio Tsuchiya, Masahiro Okada, Yuki Kagawa, Kohei Hanaoka, Kimio Usami, Yuzuru Yamazoe, Takamichi Murakami, Tetsuo Itoh
    SOC NUCLEAR MEDICINE INC, 2009年05月, JOURNAL OF NUCLEAR MEDICINE, 50, 英語
    研究発表ペーパー・要旨（国際会議）

  • 早期肝癌診断におけるGd‐EOB‐DTPA‐MRIの有用性について
    小来田幸世, 今井康晴, 福田和人, 澤井良之, 岩崎哲也, 土本雄亮, 下野沙織, 中松大, 湯口清徳, 池添世里子, 北川晶規, 松本康史, 中原征則, 厨子慎一郎, 黒川正典, 森本修邦, 高村学, 足立史朗, 岡田真広, 熊野正士, 村上卓道
    (一社)日本肝臓学会, 2009年04月30日, 肝臓, 50(Supplement 1) (Supplement 1), A369 - A369, 日本語

  • 経過中に間質肉腫への悪性転化が疑われた前立腺cystic epithelial-stromal tumorの一例
    荒木 哲朗, 桑原 雅知, 今岡 いずみ, 下野 太郎, 柳生 行伸, 熊野 正士, 香川 祐毅, 清水 利栄, 葉 輝明, 任 誠雲, 坪山 尚寛, 小塚 健倫, 岡田 真広, 米矢 吉宏, 足利 竜一朗, 細野 眞, 村上 卓道, 清水 信貴, 植村 天受, 前西 修, 木村 雅友, 筑後 孝章
    (公社)日本医学放射線学会, 2009年04月, Japanese Journal of Radiology, 27(Suppl.) (Suppl.), 55 - 55, 日本語

  • 13 ガドキセト酸ナトリウムを用いた肝ダイナミック撮像におけるタイミングの検討(MR検査 肝臓-Gd-EOB-DTPA,第36回日本放射線技術学会秋季学術大会)
    小松 みゆき, 中塚 隆之, 西松 和彦, 上田 傑, 澄田 貢, 香川 祐毅, 村上 卓道
    公益社団法人日本放射線技術学会, 2008年09月20日, 日本放射線技術學會雜誌, 64(9) (9), 日本語

  • 上腹部領域における3テスラMRIの初期経験
    大西裕満, 金東石, 堀雅敏, 坪山尚寛, 東原大樹, 前田登, 桑原雅知, 三上恒治, 大須賀慶悟, 友田要, 中村仁信, 村上卓道
    (公社)日本医学放射線学会, 2008年04月25日, Radiation Medicine, 26(Suppl.I) (Suppl.I), 43 - 43, 日本語

  • 93) 造影後期MRIとFDG-PETで早期診断と治療効果判定を評価した心サルコイドーシスの1例(第104回日本循環器学会近畿地方会)
    武輪 光彦, 谷口 貢, 岩永 善高, 石瀬 卓郎, 小林 直也, 平野 豊, 宮崎 俊一, 筑後 孝章, 足利 竜一朗, 村上 卓道, 細野 眞
    社団法人日本循環器学会, 2008年04月20日, Circulation journal : official journal of the Japanese Circulation Society, 72(0) (0), 日本語

  • 3T MRIによる子宮体癌のT2強調像:1.5Tとの比較
    堀雅敏, 金東石, 大西裕満, 中矢泰裕, 巽光朗, 大須賀慶悟, 友田要, 中村仁信, 今岡いずみ, 村上卓道
    (公社)日本医学放射線学会, 2008年02月28日, 日本医学放射線学会総会抄録集, 67th, S341 - S341, 日本語

  • 肝細胞癌の画像診断とIVRによる治療：CTの役割と最新動向.
    村上 卓道
    2008年02月, Clinician Clinician, 55, 180 - 188

  • 集束超音波治療における磁気共鳴による非侵襲・自己参照型温度分布画像化のための目標点追尾
    黒田輝, 国領大介, 熊本悦子, 岡田篤哉, 村上卓道
    2008年, Thermal Medicine, 24(Supplement) (Supplement)

  • 救急単純Ｘ線診断：胸腹部急性疾患を中心に：肺炎の単純Ｘ線所見
    小塚健倫, 村上 卓道
    2008年, 救急医学, 32, 1763 - 1768

  • Perfusion CT.
    村上 卓道
    2008年, Clinician, 55, 1199 - 1206

  • 骨関節画像診断の最前線 新しい撮影法，撮影装置と画像処理 全身MRI
    中西克之, 村上 卓道
    2008年, 臨床画像, 24(11) (11), 1352 - 1360

  • 造影CTにおける至適造影剤投与方法を探る 投与量からみた造影剤の使い分け
    熊野 正士, 桑原 雅知, 村上 卓道
    産業開発機構, 2008年, 映像情報Medical, 40(8) (8), 686 - 689, 日本語

  • 子宮頸癌 MR撮影と読影の基本
    今岡 いずみ, 安藤理奈, 村上 卓道
    2008年, 画像診断, 28(7) (7), 613 - 621

  • 最新腹部MDCT診断
    村上 卓道, 葉 輝明, 柳生 行伸
    2008年, 近畿大学医学会雑誌, 33, 3 - 7

  • 内分泌臓器の画像診断：膵・副腎・卵巣
    熊野 正士, 今岡 いずみ, 岡田 真広, 村上 卓道
    2008年, 総合臨床, 57, 427 - 432

  • 腹部の最新MDCT診断.
    村上 卓道
    2008年, 伊丹市医師会誌, 154, 2 - 6

  • 肝癌診療の最近の進歩と問題点：CT・MRI診断.
    岡田 真広, 村上 卓道
    2008年, 外科治療, 98, 133 - 146

  • 三上恒治, 村上 卓道
    2008年01月, 臨床婦人科産科, 62, 48 - 51

  • 黒田 輝, 国領 大介, 熊本 悦子, ロハス ジョナタン, 岡田 篤哉, 村上 卓道
    本研究の狙いは, 呼吸性の移動・変形をする肝臓内に設定した治療目標部位に対して, 治療用超音波の焦点をガイドするための磁気共鳴技術の開発である. ここに提案する我々の方法では血管を肝組織の追尾に使うこととした. 自由呼吸下における肝の矢状面におけるシネ画像をフィルタリングすることによって血管断面の重心を求め, それを解析することにより肝組織の並進距離と伸縮距離を解析した. 超音波焦点を置くべき治療目標点を, 血管の瞬時位置に基づいて推定した. 2名の健常ボランティアに対する実験において血管輪郭を描くためには, 空間マトリクスの大きさとして128×128が必要であった. 肝の並進距離は頭尾方向において19.6±3.6 mm, 腹背方向において3.1±1.4 mmであった. 伸縮距離は頭尾方向において3.7±1.1 mm, 腹背方向において3.0±1.2 mmであった. 検討に用いた血管の組み合わせでは, 目標点の実測位置と推定位置のずれが, 頭尾方向で0.7±0.5 mm, 腹背方向で0.6±0.4, 直線距離にして1.0±0.5 mmであった. 生体熱伝導方程式によって温度上昇をシミュレートした結果, 完全に息止めをした場合に較べて, 焦点周囲における肝組織の温度上昇のロスは20％程度であった. これらの結果は, 血管重心位置の実測に基づく提案法が臓器内の特定部位の動的な捕捉と, 加温領域をカバーする温度分布撮像面の追尾に, 十分な能力を有することを示した.
    Japanese Society for Thermal Medicine, 2007年12月20日, 日本ハイパーサーミア学会誌 = Japanese journal of hyperthermic oncology, 23(4) (4), 181 - 193, 英語

  • 4.Shuttle helical scanによる腹部造影検査 : DSAとの比較(一般演題抄録,第62回近畿大学医学会学術講演会)
    香川 祐毅, 柳生 行伸, 村上 卓道, 下野 太郎, 桑原 雅知, 任 誠雲, 坪山 尚寛, 荒木 哲朗, 松久保 祐子, 安藤 理奈, 葉 輝明, 熊野 正士, 今岡 いずみ, 足利 竜一郎, 米矢 吉宏, 土屋 典生, 岡田 真広, 細野 眞
    近畿大学, 2007年09月, 近畿大学医学雑誌, 32(3) (3), 日本語

  • 放射線科医に必要な妊娠，胎児，新生児の画像診断：放射線診断から不妊医療へのアプローチ
    今岡 いずみ, 任誠雲, 村上 卓道
    2007年07月, 画像診断, 27(7) (7), 792 - 801

  • 肝細胞癌治療としてのIVR：外科医 が知っておくべきIVRのすべて：肝胆膵領域におけるIVRの適応と限界
    村上 卓道, 柳生行伸, 熊野 正士
    2007年07月, 外科治療, 97, 34 - 43

  • 今岡 いずみ, 村上 卓道
    2007年06月, 臨婦産, 61, 801 - 805

  • MRIの進歩・普及がCTとの関係に与える変化とは
    村上 卓道
    2007年05月, 新医療, 34, 48 - 51

  • 64列MDCTの検査と診断Ⅱ 脳神経領域
    足利 竜一朗, 柳生行伸, 村上 卓道
    2007年05月, Innervison Innervison, 22(5) (5), 106 - 109

  • Disseminated peritoneal leiomyomatosisの一例
    東原大樹, 金東石, 堀雅敏, 中城和也, 前田登, 大西裕満, 桑原雅知, 三上恒治, 中田早紀, 大須賀慶悟, 友田要, 村上卓道, 中村仁信
    (公社)日本医学放射線学会, 2007年04月25日, Radiation Medicine, 25(Suppl.I) (Suppl.I), 72 - 72, 日本語

  • 3Dグラジエントエコー法(LAVAシーケンス)による肝のダイナミックMRI:初期経験の報告
    前田登, 村上卓道, 堀雅敏, 金東石, 大西裕満, 桑原雅知, 東原大樹, 坪山尚寛, 三上恒治, 大須賀慶悟, 友田要, 中村仁信
    (公社)日本医学放射線学会, 2007年04月25日, Radiation Medicine, 25(Suppl.I) (Suppl.I), 77 - 77, 日本語

  • フェルカルボトラン造影MRIを用いた肝腫瘤性病変の鑑別について
    東原大樹, 村上卓道, 金東石, 堀雅敏, 大西裕満, 中田早紀, 桑原雅知, 安部久志, KHANKAN Azzam, 三上恒治, 大須賀慶悟, 友田要, 高橋哲, 鳴海善文, 中村仁信
    (公社)日本医学放射線学会, 2007年04月25日, Radiation Medicine, 25(Suppl.I) (Suppl.I), 61 - 61, 日本語

  • 腹部造影CTにおける至適撮像条件の基礎的検討
    大西裕満, 村上卓道, 三上恒治, 金東石, 堀雅敏, 東原大樹, 大須賀慶悟, 中田早紀, 桑原雅知, 安部久志, KHANKAN Azzam, 友田要, 中村仁信, 岡田篤哉, 丸川太朗
    (公社)日本医学放射線学会, 2007年04月25日, Radiation Medicine, 25(Suppl.I) (Suppl.I), 61 - 61, 日本語

  • 腹部MRI画像診断の最近の話題
    熊野 正士, 村上 卓道, 金東石
    2007年04月, Medico Medico, 38, 133 - 135

  • 3テスラ装置におけるMRCPの画質評価:1.5テスラ装置との比較
    大西裕満, 金東石, 堀雅敏, 村上卓道, 中矢泰裕, 大須賀慶悟, 巽光朗, 三上恒治, 友田要, 中村仁信
    (公社)日本医学放射線学会, 2007年02月28日, 日本医学放射線学会学術集会抄録集, 66th, S348 - S348, 日本語

  • MRCP用経口消化管陰性造影剤ボースデルの3テスラ環境における至適濃度の検討
    大西裕満, 金東石, 堀雅敏, 村上卓道, 中矢泰裕, 東原大樹, 前田登, 大須賀慶悟, 友田要, 中村仁信
    (公社)日本医学放射線学会, 2007年02月28日, 日本医学放射線学会学術集会抄録集, 66th, S348 - S348, 日本語

  • 骨盤部の3T MRI:T2強調FSE撮像パラメータの最適化
    堀雅敏, 金東石, 大西裕満, 中矢泰裕, 巽光朗, 大須賀慶悟, 友田要, 中村仁信, 村上卓道
    (公社)日本医学放射線学会, 2007年02月28日, 日本医学放射線学会学術集会抄録集, 66th, S340 - S340, 日本語

  • Automated Determination of the Liver Boundary in CT Data Based on Anatomical Knowledge and Level Set Method
    Foruzan Amir. H., Zoroofi Raza A., Sato Yoshinobu, HORI Masatoshi, MURAKAMI Takamichi, NAKAMURA Hironobu, TAMURA Shinichi
    Automatic determination of the liver boundary in CT images is difficult due to similar intensity of liver with respect to its surrounding tissues, poor in-plane and inter-plane resolutions, and partial volume effect. Assumptions made in previous liver segmentation algorithms cannot be used to all cases since liver shape and location varies much in abdomen. In this article, we first estimate an initial mask to find intensity of liver accurately. We then convert gray-scale CT images to colored images so that separate liver tissues in lower slices can be seen well. The borders of these estimated tissues are used as the initial border of liver and tuned by active contour method. We extract the required parameters of each dataset from itself. Results are in agreement with the proposed method.
    一般社団法人電子情報通信学会, 2007年01月20日, 電子情報通信学会技術研究報告. MI, 医用画像, 106(510) (510), 83 - 86, 英語

  • 強力集束超音波療法の現状とこれから 集束超音波治療のための磁気共鳴による非侵襲・自己参照型温度分布画像化法
    黒田輝, 国領大介, 熊本悦子, ROJAS Jonathan, BILGIN Keserci, 岡田篤哉, 村上卓道
    2007年, Thermal Medicine, 23(Supplement) (Supplement)

  • 磁気共鳴による非侵襲・自己参照型温度分布画像化法の実用化
    黒田輝, 黒田輝, 国領大介, 熊本悦子, ROJAS Jonathan, 岡田篤哉, 村上卓道
    2007年, Thermal Medicine, 23(Supplement) (Supplement)

  • 肝悪性腫瘍における画像診断の進歩
    熊野 正士, 岡田 真広, 村上 卓道
    2007年, 癌と化学療法

  • びまん性肝疾患におけるCT/MRIの役割肝胆膵
    村上 卓道, 岡田 真広, 熊野 正士, 今岡 いずみ, 下野 太郎, 足利 竜一朗
    2007年, 肝胆膵における画像診断の新展開, 55(4) (4), 607 - 617

  • 肝癌の描出と肝機能評価 最新のMDCTとMRI
    村上 卓道, 熊野 正士, 岡田 真広, 柳生 行伸, 下野 太郎, 今岡 いずみ, 足利 竜一朗
    2007年, 臨床放射線, 52(8) (8), 996 - 1005

  • 64列MDCTの検査と診断 Ⅱ 脳神経領域
    足利 竜一朗, 栁生 行伸, 桑原 雅知, 坪山 尚寛, 任 誠雲, 下野 太郎, 小塚 健倫, 熊野 正士, 今岡 いずみ, 村上 卓道, 米矢 吉宏, 岡田 真広, 土屋 典生, 細野 眞, 山田 浩司, 黒川 敏昭, 霜村 康平, GEメディカルシステム
    64列MDCTの臨床画像を供覧し、その実際について述べた。
    インナービジョン, 2007年, INNERVISION, 22(5) (5), 106 - 109

  • 慢性膵炎：治療：予後改善からみた適応と限界：膵炎後仮性動脈瘤に対する血管内治療
    栁生 行伸, 村上 卓道
    2006年12月, 肝胆膵, 53, 567 - 571

  • 胸部領域：胸部領域の造影CTにおけるMPR技術と3D再構成技術の臨床的有用性
    村上 卓道, 小塚 健倫
    2006年11月, Innervison Innervison, 21(11) (11), 58 - 62

  • 上腹部消化器系のCT・MRIお勧め撮像法
    村上 卓道
    2006年10月, 臨床画像

  • Step up MRI 2006 － クリニカル3T MRIの幕開け 領域別3T MRIの臨床的有用性 － 骨盤部における有用性.
    堀雅敏, 村上 卓道
    2006年09月, Innervision Innervision, 21, 15 - 18

  • 胸部領域：PET/CTの有用性
    岡田 真広, 村上 卓道
    2006年08月, Innervison Innervison, 21, 55 - 59

  • 64列MDCTによる肝臓のダイナミックCT撮像法の最適化
    村上 卓道
    2006年08月, 映像情報, 38, 749 - 755

  • Keigo Osuga, Koji Mikami, Hiroki Higashihara, Noboru Maeda, Takahiro Tsuboyama, Masatomo Kuwabara, Hiromitsu Onishi, Masatoshi Hori, Tonsok Kim, Kaname Tomoda, Takamichi Murakami, Hironobu Nakamura
    Transcatheter embolotherapy (TCE), a common procedure for interventional radiologists, comprises transcatheter delivery of embolic agents into target vessels in order to eliminate lesions or lesion-associated symptoms. Good knowledge of delivery catheters and embolic agents is essential to optimize embolization techniques and to obtain the desired therapeutic outcomes. In this review, we describe the principles and techniques of TCE for peripheral arterial and venous lesions featuring visceral aneurysms, peripheral and pulmonary arteriovenous malformations (AVMs), and varicoceles. © 2006 Japan Radiological Society.
    2006年05月, Radiation Medicine - Medical Imaging and Radiation Oncology, 24(4) (4), 309 - 314, 英語
    書評論文,書評,文献紹介等

  • 橋本和彦, 村上 卓道
    2006年05月, 消化器画像, 8, 313 - 320

  • 画像診断とIVRのための腹部血管解剖【1】骨盤 その2 子宮動脈塞栓術(UAE)に関する血管解剖
    坪山尚寛, 大須賀慶悟, 金東石, 堀雅敏, 三上恒治, 桑原雅知, 大西裕満, 東原大樹, 前田登, 友田要, 村上卓道, 中村仁信
    2006年04月30日, 日独医報, 51(1) (1), 133 - 138, 日本語

  • 村上 卓道, 大西 裕満, 金 東石, 掘 雅敏, 中村 仁信
    一般社団法人 日本肝臓学会, 2006年04月25日, 肝臓 = ACTA HEPATOLOGICA JAPONICA, 47(4) (4), 181 - 186, 日本語

  • NBCAによる塞栓術を施行した前下膵十二指腸動脈瘤破裂の1例
    三上 恒治, 友田 要, 村上 卓道, 大須賀 慶悟, 桑原 雅知, 東原 大樹, 大西 裕満, 堀 雅敏, 金 東石, 中村 仁信
    (一社)日本インターベンショナルラジオロジー学会, 2006年04月, IVR: Interventional Radiology, 21(2) (2), 213 - 213, 日本語

  • 脾動脈分岐直後の広基性動脈瘤に対してコイル塞栓術を施行した1例
    前田 登, 大須賀 慶悟, 東原 大樹, 坪山 尚寛, 三上 恒治, 大西 裕満, 桑原 雅知, 堀 雅敏, 金 東石, 友田 要, 中村 仁信, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, 2006年04月, IVR: Interventional Radiology, 21(2) (2), 216 - 216, 日本語

  • 子宮筋腫に対するMRガイド下集束超音波治療;2年間経過観察した1例
    三上恒治, 大須賀慶悟, 友田要, 中村仁信, 岡田篤哉, 村上卓道
    (一社)日本インターベンショナルラジオロジー学会, 2006年04月01日, IVR, 21(2) (2), 222 - 222, 日本語

  • 外傷性ひAVFに対してNBCAにて塞栓術を施行した1例
    坪山尚寛, 大須賀慶悟, 東原大樹, 前田登, 大西裕満, 桑原雅知, 三上恒治, 堀雅敏, 金東石, 友田要, 中村仁信, 村上卓道
    2006年04月01日, IVR, 21(2) (2), 216, 日本語

  • NBCAによる塞栓術を施行した前下すい十二指腸動脈りゅう破裂の1例
    三上恒治, 友田要, 村上卓道, 大須賀慶悟, 桑原雅知, 東原大樹, 大西裕満, 堀雅敏, 金東石, 中村仁信
    2006年04月01日, IVR, 21(2) (2), 213, 日本語

  • 動脈塞栓術を行った外傷性持続勃起症の1例
    東原大樹, 大須賀慶悟, 大西裕満, 前田登, 桑原雅知, 堀雅敏, 金東石, 中田早紀, 友田要, 村上卓道, 中村仁信, 高尾徹也, 辻村晃, 奥山明彦, 松宮清美
    2006年04月01日, IVR, 21(2) (2), 214, 日本語

  • ひ動脈分岐直後の広基性動脈りゅうに対してコイル塞栓術を施行した1例
    前田登, 大須賀慶悟, 東原大樹, 坪山尚寛, 三上恒治, 大西裕満, 桑原雅知, 堀雅敏, 金東石, 友田要, 中村仁信, 村上卓道
    2006年04月01日, IVR, 21(2) (2), 216, 日本語

  • 大西裕満, 村上 卓道
    2006年04月, 臨床婦人科産科, 60, 383 - 387

  • 村上 卓道, 大西裕満
    The Japan Society of Hepatology, 2006年04月, 肝臓, 47(4) (4), 181 - 186, 日本語

  • 四肢AVMに対するTRICKSを用いた造影MRAの検討
    東原大樹, 大須賀慶悟, 金東石, 堀雅敏, 大西裕満, 前田登, 三上恒治, 友田要, 村上卓道, 中村仁信
    (公社)日本医学放射線学会, 2006年02月25日, 日本医学放射線学会学術集会抄録集, 65th, S280-S281 - S281, 日本語

  • 上腹部のMPG多軸印可(等方性)拡散強調MRI
    堀雅敏, 村上卓道, 金東石, 大西裕満, 桑原雅知, 大須賀慶悟, 友田要, 中村仁信, 平野勝也, 野崎敦
    (公社)日本医学放射線学会, 2006年02月25日, 日本医学放射線学会学術集会抄録集, 65th, S269 - S269, 日本語

  • 上腹部領域における3テスラMRIの初期経験
    大西裕満, 金東石, 堀雅敏, 村上卓道, 東原大樹, 前田登, 坪山尚寛, 大須賀慶悟, 友田要, 中村仁信
    (公社)日本医学放射線学会, 2006年02月25日, 日本医学放射線学会学術集会抄録集, 65th, S199 - S199, 日本語

  • GDAコイル法におけるマイクロネスター・コイルの安全な留置に関する検討
    前田登, 大須賀慶悟, 坪山尚寛, 東原大樹, 三上恒治, 堀雅敏, 金東石, 友田要, 村上卓道, 中村仁信
    (公社)日本医学放射線学会, 2006年02月25日, 日本医学放射線学会学術集会抄録集, 65th, S334 - S334, 日本語

  • ISSVA分類に基づいた血管腫・血管奇形の臨床診断及び問題点
    大須賀慶悟, 東原大樹, 坪山尚寛, 前田登, 三上恒治, 堀雅敏, 金東石, 友田要, 村上卓道, 中村仁信
    (公社)日本医学放射線学会, 2006年02月25日, 日本医学放射線学会学術集会抄録集, 65th, S340-S341 - S341, 日本語

  • MDCTを用いたすい内分泌腫ようの撮影タイミングの検討
    坪山尚寛, 金東石, 村上卓道, 堀雅敏, 大須賀慶悟, 三上恒治, 友田要, 中村仁信
    2006年02月25日, 日本医学放射線学会学術集会抄録集, 65th, S296, 日本語

  • MDCTを用いた膵内分泌腫瘍の撮影タイミングの検討
    坪山 尚寛, 金 東石, 村上 卓道, 堀 雅敏, 大須賀 慶悟, 三上 恒治, 友田 要, 中村 仁信
    (公社)日本医学放射線学会, 2006年02月, 日本医学放射線学会学術集会抄録集, 65回, S296 - S296, 日本語

  • ちょっとハイレベルの日常遭遇する婦人科疾患:腹膜病変：嚢胞性中皮腫
    津田恭, 村上 卓道
    2006年02月, 画像診断, 26, 192 - 193

  • 近傍濃淡情報を用いた分岐点解析による肝臓CT画像からの血管3次元木構造の抽出手法
    山本 宗主, 桝本 潤, 堀 雅敏, 佐藤 嘉伸, 村上 卓道, 中村 仁信, 田村 進一
    肝臓手術計画において血管構造の抽出、認識は重要である.我々は臨床現場で利用可能な, 簡便な操作と許容範囲内の処理時間を満たす追跡方血管中心線抽出手法を提案する.提案手法では, 初期情報として追跡開始位置・方向を決定するための画像上の2点を必要とする.追跡方向の検出および分岐・端点の判定では, 現在地を中心とした球内部の濃淡情報を解析することで適切な閾値設定による血管領域の抽出が可能かを判定し, 閾値設定が可能な位置においては推定した閾値を用いた領域拡張法を用いた検出アルゴリズムを, 閾値設定が困難と判断された位置では, 球内部において高い画素値の集中する方向を検出するアルゴリズムをそれぞれ使い分けて追跡を行う.提案手法を14例の肝動脈造影CT画像に適用し, 医師が視認出来る亜区域枝の8割の抽出に成功した.
    一般社団法人電子情報通信学会, 2006年01月20日, 電子情報通信学会技術研究報告. MI, 医用画像, 105(579) (579), 57 - 60, 日本語

  • 腹部領域における3T MRIの画質改善法
    上口貴志, 小山佳寛, 川原雅昭, 小水満, 堀雅敏, 金東石, 村上卓道
    2006年, 日本放射線技術学会総会学術大会予稿集, 62nd

  • 肝癌のRFA治療におけるReal-time Virtual Sonography(RVS)の有用性
    北田 学利, 村上 卓道, 松田 高明, 中城 和也, 南谷 かおり, 桜井 康介, 大須賀 慶悟, 田村 信司, 中村 仁信, 岸野 文一郎
    (公社)日本超音波医学会, 2006年01月, 超音波医学, 33(1) (1), 97 - 97, 日本語

  • 集束超音波治療
    村上 卓道, 岡田篤哉
    2006年, 4, 96 - 99

  • 女性生殖器の画像診断 卵巣腫瘍
    今岡 いずみ, 清水利栄, 任誠雲, 坪山 尚寛, 下野 太郎, 足利 竜一朗, 村上 卓道
    2006年, 日獨医報, 51, 418 - 427

  • 症例５ 婦人科
    任誠雲, 今岡 いずみ, 村上 卓道
    2006年, クリニカルプラクティス Clinical Practice, 25, 45 - 50

  • Perfusion CTによる肝腫瘍の血流動態診断
    橋本和彦, 村上 卓道
    2006年01月, Radiology Frontier Radiology Frontier, 9, 47 - 52

  • 原理,読影の基礎 (今月の臨床 婦人科の新しい画像診断法--PETを中心として) -- (ポジトロンエミッショントモグラフィ(PET))
    巽 光朗, 村上 卓道, 中村 仁信
    医学書院, 2005年11月, 臨床婦人科産科, 59(11) (11), 1444 - 1447, 日本語

  • 卵巣腫瘍と紛らわしかった虫垂粘液腺癌の1例
    桑原雅知, 中城和也, 前田登, 坪山尚寛, 東原大樹, 大西裕満, 三上恒治, 中田早紀, 堀雅敏, 大須賀慶悟, 金東石, 村上卓道, 友田要, 中村仁信, 安部久志
    2005年09月05日, 日本医学放射線学会秋季臨床大会抄録集, 41st, S488, 日本語

  • 非肝硬変症例と肝硬変症例における門脈への造影剤到達時間の検討
    大西裕満, 村上卓道, 金東石, 堀雅敏, 大須賀慶悟, 中田早紀, 三上恒治, 桑原雅知, 東原大樹, 前田登, 坪山尚寛, 友田要, 中村仁信
    2005年09月05日, 日本医学放射線学会秋季臨床大会抄録集, 41st, S486, 日本語

  • 癌性腹膜炎と鑑別が難しかった右腎盂癌に合併した結核性腹膜炎の一例
    前田登, 東原大樹, 桑原雅知, 中城和也, 坪山尚寛, 大西裕満, 三上恒治, 中田早紀, 堀雅敏, 大須賀慶悟, 金東石, 村上卓道, 友田要, 中村仁信
    2005年09月05日, 日本医学放射線学会秋季臨床大会抄録集, 41st, S489, 日本語

  • 膵頭十二指腸切除術後の胃十二指腸動脈断端部仮性動脈瘤に対して経カテーテル的塞栓術による止血に難渋した1例
    三上恒治, 友田要, 村上卓道, 大須賀慶悟, 東原大樹, 大西裕満, 桑原雅知, 堀雅敏, 金東石, 中村仁信
    2005年09月05日, 日本医学放射線学会秋季臨床大会抄録集, 41st, S537, 日本語

  • 副腎原発のGanglioneuromaの一例
    東原大樹, 金東石, 堀雅敏, 中田早紀, KHANKAN Azzam, 大西裕満, 桑原雅知, 安部久志, 大須賀慶悟, 友田要, 村上卓道, 中村仁信, 高橋哲, 鳴海善文
    (公社)日本医学放射線学会, 2005年07月25日, 日本医学放射線学会雑誌, 65(3) (3), 323 - 323, 日本語

  • MDCTを用いた造影CTに対しSPIO造影MRI検査を追加することの意義について―転移性肝腫ようにおける検出能の比較検討
    大西裕満, 村上卓道, 堀雅敏, 金東石, 桑原雅知, 安部久志, 大須賀慶悟, 中田早紀, 東原大樹, KHANKAN Azzam, 三原直樹, 友田要, 中村仁信
    2005年07月25日, 日本医学放射線学会雑誌, 65(3) (3), 322, 日本語

  • NBCAによる塞栓術を施行した前下膵十二指腸動脈瘤破裂の1例
    三上 恒治, 友田 要, 村上 卓道, 大須賀 慶悟, 桑原 雅知, 東原 大樹, 大西 裕満, 堀 雅敏, 金 東石, 中村 仁信
    (一社)日本インターベンショナルラジオロジー学会, 2005年07月, IVR: Interventional Radiology, 20(3) (3), 330 - 330, 日本語

  • 動脈塞栓術を行った外傷性持続勃起症の1例
    東原大樹, 大須賀慶悟, 大西裕満, 前田登, 桑原雅知, 堀雅敏, 金東石, 中田早紀, 友田要, 村上卓道, 中村仁信, 高尾徹也, 辻村晃, 奥山明彦, 松宮清美
    (一社)日本インターベンショナルラジオロジー学会, 2005年07月01日, IVR, 20(3) (3), 330 - 330, 日本語

  • NBCAによる塞栓術を施行した前下すい十二指腸動脈りゅう破裂の1例
    三上恒治, 友田要, 村上卓道, 大須賀慶悟, 桑原雅知, 東原大樹, 大西裕満, 堀雅敏, 金東石, 中村仁信
    2005年07月01日, IVR, 20(3) (3), 330, 日本語

  • 腸間膜のCastleman病の1例
    東原 大樹, 金 東石, 堀 雅敏, 中田 早紀, Khankan Azzam, 大西 裕満, 桑原 雅知, 安部 久志, 杉浦 孝司, 大須賀 慶悟, 友田 要, 村上 卓道, 中村 仁信, 高橋 哲, 鳴海 善文
    バイエル薬品(株), 2005年06月, 日独医報, 50(2) (2), 393 - 393, 日本語

  • 浸潤性発育を示した右副腎原発悪性リンパ腫の1例
    中田 早紀, 金 東石, 堀 雅敏, 大須賀 慶悟, 杉浦 孝司, 安部 久志, 桑原 雅知, 大西 裕満, 横江 勇, 東原 大樹, Khankan Azzam, 友田 要, 村上 卓道, 中村 仁信, 高橋 哲, 鳴海 善文
    バイエル薬品(株), 2005年06月, 日独医報, 50(2) (2), 399 - 399, 日本語

  • 成人型Wilms腫瘍の1例
    大西 裕満, 金 東石, 安部 久志, 村上 卓道, 堀 雅敏, 大須賀 慶悟, 杉浦 孝, 中田 早紀, 桑原 雅知, Khankan Azzam, 東原 大樹, 友田 要, 中村 仁信, 高橋 哲, 鳴海 善文, 星田 義彦
    バイエル薬品(株), 2005年06月, 日独医報, 50(2) (2), 400 - 400, 日本語

  • 生体肝移植右葉グラフトにおけるドナー・レシピエントの術後肝容積の長期的推移(第105回日本外科学会定期学術集会)
    久保田 勝, 堂野 恵三, 橋本 和彦, 丸橋 繁, 宮本 敦史, 永野 浩昭, 堀 雅敏, 村上 卓道, 梅下 浩司, 門田 守人
    一般社団法人日本外科学会, 2005年04月05日, 日本外科学会雑誌, 106, 223 - 223, 日本語

  • 【マルチモダリティによるAbdominal Imaging(臨床編) 日常臨床における戦略と選択】肝腫瘍(インターベンションも含めて) 肝腫瘍の診断と治療 肝細胞がんと転移性肝腫瘍におけるCT,MRIの診断と治療 大阪大学医学部附属病院
    桑原 雅知, 東原 大樹, 大西 裕満, 三上 恒治, Khankan Azzam, 安部 久志, 中田 早紀, 堀 雅敏, 大須賀 慶悟, 金 東石, 村上 卓道, 友田 要, 中村 仁信
    (株)インナービジョン, 2005年04月, INNERVISION, 20(6) (6), 1 - 5, 日本語

  • NBCAにて塞栓術を施行した顔面AVMの2例
    大須賀慶悟, KHANKAN Azzam, 友田要, 村上卓道, 三上恒治, 東原大樹, 金東石, 堀雅敏, 中田早紀
    2005年04月01日, IVR, 20(2) (2), 220, 日本語

  • IFN‐α併用5‐FU肝動注療法に伴う血小板減少症に対して部分的ひ動脈塞栓術が有効であった肝細胞癌の1例
    三上恒治, 村上卓道, 大須賀慶悟, 友田要, 中村仁信, 永野浩昭, 門田守人, 丸川太朗
    2005年04月01日, IVR, 20(2) (2), 213 - 214, 日本語

  • HCCに対するTAEの治療成績
    桑原雅知, 村上卓道, 三上恒治, 大西裕満, 中田早紀, 堀雅敏, 大須賀慶悟, 金東石, 友田要
    (公社)日本医学放射線学会, 2005年02月25日, 日本医学放射線学会学術集会抄録集, 64th, S264 - S264, 日本語

  • 320mg濃度ヨード造影剤を用いた腹部CTにおける造影能の検討
    大西裕満, 村上卓道, 金東石, 堀雅敏, 大須賀慶悟, 中田早紀, 三上恒治, 東原大樹, 友田要
    (公社)日本医学放射線学会, 2005年02月25日, 日本医学放射線学会学術集会抄録集, 64th, S354 - S354, 日本語

  • フェルカルボトラン造影MRIを用いた肝腫りゅう性病変の鑑別
    東原大樹, 村上卓道, 金東石, 堀雅敏, 大西裕満, 中田早紀, 安部久志, 大須賀慶悟, 友田要
    2005年02月25日, 日本医学放射線学会学術集会抄録集, 64th, S278, 日本語

  • 肝腫りゅう濃染パターンの評価:Multi‐shot SE EPIシーケンスによるSPIO造影dynamic MRIの有用性
    堀雅敏, 村上卓道, 金東石, 安部久志, 大西裕満, 桑原雅知, 中田早紀, 大須賀慶悟, 友田要
    2005年02月25日, 日本医学放射線学会学術集会抄録集, 64th, S277, 日本語

  • 慢性ウィルス性肝炎に合併した原発性肝腫よう外科切除例の検討
    金東石, 村上卓道, 堀雅敏, 安部久志, 大西裕満, 桑原雅知, 中田早紀, 大須賀慶悟, 友田要
    2005年02月25日, 日本医学放射線学会学術集会抄録集, 64th, S273, 日本語

  • R Iannaccone, C Catalano, F Mangiapane, R Passariello, T Murakami, M Hori
    W B SAUNDERS CO, 2005年02月, GASTROENTEROLOGY, 128(2) (2), 522 - 523, 英語
    速報，短報，研究ノート等（学術雑誌）

  • TIPSが有効であった肝性胸水の1例
    東原 大樹, 大須賀 慶悟, 友田 要, Khankan Azzam, 大西 裕満, 金 東石, 堀 雅敏, 三原 直樹, 中田 早紀, 桑原 雅知, 安部 久志, 高橋 哲, 鳴海 善文, 村上 卓道, 中村 仁信, 宇山 宏和, 伊藤 裕章
    (一社)日本インターベンショナルラジオロジー学会, 2005年02月, IVR: Interventional Radiology, 20(2) (2), 213 - 213, 日本語

  • 3次元CT画像を用いた門脈末梢部の大局位置情報に基づく肝区域の推定
    山本 宗主, 堀 雅敏, 佐藤 嘉伸, 村上 卓道, 中村 仁信, 田村 進一
    肝臓手術計画において, 血管構造解析および肝区域の推定は重要である.我々は, 肝区域推定に必要となる門脈の解剖学的ラベル付けを目的とし, 正常変異と呼ばれる門脈分岐構造のバリエーションや, 複数の血管に同一のラベルが付けられる場合においても正しくラベル付けが行える手法を提案する.まず抽出された門脈をグラフ構造化する.ユーザは, 手動で定義する分割平面および分割平面付近のラベル付けを適切に行うためのマージン空間幅によってグラフを階層的に分割していくことでラベル付けを行う.マージン空間内においては, 適切なラベル付けを部分木の大局的情報に基づく後処理によって決定する.本手法を実装したツールを専門医が用い, 正常変異例を含む12例に対してラベル付けを行い, 11例について, 専門医が正しいとする結果を得ることを確認した.また, 本手法の性能評価実験を行い, マージン空間幅を設けることによる分割結果の安定性の検証を行った.
    一般社団法人電子情報通信学会, 2005年01月15日, 電子情報通信学会技術研究報告. MI, 医用画像, 104(580) (580), 169 - 174, 日本語

  • Signa Excite HD 1.5TによるLAVA sequenceを用いた腹部MR診断:Routine clinical MRI
    金 東石, 村上 卓道
    産業開発機構, 2005年, 映像情報Medical, 2006年(14) (14), 62 - 67, 日本語

  • 肝臓のMDCT：最適撮像法とその有用性
    村上 卓道
    2005年, Rad Fan Rad Fan, 12, 9 - 13

  • 1.5テスラMRI撮影装置Signa Excite HDの初期使用経験：上腹部造影ダイナミック用高速撮像シーケンスLAVAを中心に
    大西裕満, 村上 卓道
    2005年, Rad Fan Rad Fan, 3, 54 - 56

  • 64列ボリュームCT:LightSpeed VCT臨床使用経験
    村上 卓道, 金 東石
    2005年, Innervision Innervision, 20, 115 - 118

  • 集束超音波治療
    村上 卓道, 岡田篤哉
    2005年, Cancer Frontier Cancer Frontier, 7, 158 - 165

  • 集束超音波治療装置ExAblate2000を用いた子宮筋腫の治療
    三上恒治, 村上 卓道
    2005年, Medical Science Digest Medical Science Digest, 31, 223 - 226

  • 集束超音波療法
    村上 卓道
    2005年, 綜合臨床, 54, 1088

  • 金 東石, 村上 卓道
    2005年, 消化器画像, 7, 264 - 266

  • 肝良性腫瘍および腫瘍類似病変の画像診断：肝血管筋脂肪腫
    金 東石, 村上 卓道
    2005年, 画像診断, 25, 291 - 296

  • 肝細胞癌（HCC）：TAEの現況：阪大病院におけるTAEの現況
    大須賀慶悟, 村上 卓道
    2005年, IVR会誌, 20, 52 - 53

  • Mikami K, 村上 卓道
    集束超音波療法 (Focused Ultrasound Surgery;FUS) は, 焦点域の組織のみを壊死させる低侵襲性熱凝固治療である.50年前より超音波ガイドによるFUS治療の臨床応用が報告されてきたが, 不正確な位置情報, 温度測定法の欠如, 治療効果の評価法の欠如により十分な治療成績が得られていなかった.しかしながら, MRIガイドによる正確な位置情報の取得と治療中の温度計測により安全で正確な治療が可能になった.また造影MRIにより治療直後に治療効果を評価することが可能となった.本稿ではMRIガイド下FUS治療の原理, 治療方法と最近の臨床応用について述べる.
    Japanese Society for Thermal Medicine, 2005年, Jpn J Hyperthermic Oncol, 21(3) (3), 129 - 137, 英語

  • Multi‐phasic MDCTによる肝細胞癌の門脈腫よう栓の診断能
    金東石, 村上卓道, 堀雅敏, 安部久志, 大西裕満, 中田早紀, 友田要, 大須賀慶悟, 桑原雅知
    2004年09月25日, 日本医学放射線学会雑誌, 64(6) (6), S415, 日本語

  • MDCTを用いた造影CTにSPIO造影MRIを追加する意義について―転移性肝腫ようにおける検出能の比較
    大西裕満, 村上卓道, 堀雅敏, 金東石, 桑原雅知, 安部久志, 大須賀慶悟, 中田早紀, 三上恒治
    2004年09月15日, 日本磁気共鳴医学会雑誌, 24(Supplement(Sept)) (Supplement(Sept)), 273, 日本語

  • 特異な発育形態を示した子宮癌肉腫の1例
    安部 久志, 村上 卓道, 金 東石, 堀 雅敏, 中田 早紀, 桑原 雅知, 大西 裕満, Khankan Azzam, 大須賀 慶悟, 友田 要, 中村 仁信, 高橋 哲, 鳴海 善文
    (公社)日本医学放射線学会, 2004年09月, 日本医学放射線学会雑誌, 64(6) (6), S418 - S418, 日本語

  • 村上 卓道, 安富 正幸
    大腸癌診療の画像診断においては,原発巣の描出,進達度診断と共に,転移巣の発見および鑑別診断が重要になってくる.原発巣の描出には一般的にはバリウム注腸造影や大腸ファイバーが行われており,その精度と有用性は疑うべくもない.しかしこれらの検査は,腫瘍の形態や壁の硬さなどの様子を内腔より観察するものであり,壁内外や他臓器への進展度(T分類),リンパ節転移(N分類),遠隔転移(M分類)を評価することはできない.
    近年,CTやMRIでは高速撮像法が飛躍的に進歩し,時間,空間分解能の高い画像が撮れるようになった.特に,近年臨床応用可能となったマルチスライスCTでは,従来のヘリカルCTに比して10倍以上の高速撮像が可能であり,広い範囲を薄いスライス厚で撮像できるようになった.この画像から,描出に関しては腸管内腔からの3次元画像である仮想内視鏡像を作成することができる.また,腫瘍と接する壁に垂直な画像を再構成することもできるため,腫瘍の壁浸潤も評価できる.更に,広い範囲のリンパ節,遠隔転移の評価も可能である.このように,腫瘍のみならず転移巣も詳細に評価することができる.一方,MRIはマルチスライス CT程の空間分解能はないが,そのコントラスト分解能の高さから腫瘍の壁内浸潤を評価しやすい.広い範囲の代謝の更新した部分を描出できるPETは,原発巣の描出にも有用とされているが,現在は主に局所再発の有無やリンパ節転移,遠隔転移の有無の評価に用いられている.前述のMDCTとの融合像(CT-PET像)を用いれば,更に描出能の向上が期待できる.
    大腸がんの転移しやすい臓器としては,門脈血流の帰る肝臓が第一に挙げられる.肝転移は,手術や動注化学療法など比較的治療できる可能性が高い部位であり,またその有無は原発巣の手術の適応にもかかわってくるため,その評価は非常に重要である.従来は,動脈性門脈造影下CT(CTAP)がもっとも描出能が高く有用とされていたが,その侵襲性の高さや高額な検査費用が問題であった.最近は肝臓の網内系に選択的に取り込まれる超常磁性体酸化鉄粒子(Superparamagnetic iron oxide,SPIO)を用いた造影MRIがCTAPに劣らない診断能があるとされている.
    MDCT,MRI,PETをうまく組み合わせることにより,腫瘍のみならず転移巣も詳細に,低侵襲に評価することができる.
    日本大腸肛門病学会, 2004年09月01日, 日本大腸肛門病学会雑誌, 57(9) (9), 487 - 487, 日本語

  • すい腫よう血流の定量的評価:Xe‐CTとperfusion‐CTにおける比較検討
    安部久志, 村上卓道, 金東石, 堀雅敏, 大須賀慶悟, 河田修治, 中田早紀, KHANKAN A, 桑原雅知
    2004年07月25日, 日本医学放射線学会雑誌, 64(5) (5), 344, 日本語

  • OP-3-088 perfusion CTを用いた直腸癌局所再発に対する新しい画像診断法の試み(大腸11)
    木谷 光太郎, 大植 雅之, 堀 雅敏, 工藤 正幸, 関本 貢嗣, 山本 浩文, 池田 正孝, 村上 卓道, 中村 仁信, 門田 守人
    一般社団法人日本消化器外科学会, 2004年07月01日, 日本消化器外科学会雑誌, 37(7) (7), 1113 - 1113, 日本語

  • 膵に発生したlymphoepithelial cystの1例
    坪山 尚寛, 金 東石, 大西 裕満, 安部 久志, 桑原 雅知, 中田 早紀, 河田 修治, 堀 雅敏, 大須賀 慶悟, 友田 要, 村上 卓道, 中村 仁信
    (公社)日本医学放射線学会, 2004年07月, 日本医学放射線学会雑誌, 64(5) (5), 344 - 345, 日本語

  • 慢性DICでひ出血を合併した下肢静脈奇形の1例
    大須賀慶悟, 古妻理之, 友田要, 村上卓道, 中村仁信, 鵜飼勲, 池田正孝
    2004年07月01日, IVR, 19(3) (3), 296, 日本語

  • 肝cavernous hemangioma with severe hyalinization 術前診断に苦慮した肝腫瘤
    桑原 雅知, 大西 裕満, 安部 久志, Khankan Azzam, 松村 太, 中田 早紀, 堀 雅敏, 大須賀 慶悟, 杉浦 孝司, 高橋 哲, 金 東石, 鳴海 善文, 友田 要, 村上 卓道, 岡田 篤哉, 中村 仁信
    バイエル薬品(株), 2004年04月, 日独医報, 49(1) (1), 124 - 125, 日本語

  • 嚢胞性腫瘤を呈した腎嫌色素細胞癌の1例
    桑原 雅知, 鳴海 善文, 高橋 哲, 堀 雅敏, 三宅 修, 辻本 裕一, 青笹 克之, Fahrni M, Khankan A, 安部 久志, 杉原 英治, 河田 修治, 中田 早紀, 大須賀 慶悟, 村上 卓道, 友田 要, 中村 仁信
    バイエル薬品(株), 2004年04月, 日独医報, 49(1) (1), 141 - 141, 日本語

  • T Murakami, M Hori, T Kim, K Hashimoto, K Dono, S Hayashi, E Sugihara, H Nagano, S Sase, M Sakon, M Monden, H Nakamura
    Objective: The purpose of this study was to separately measure the arterial and portal venous tissue blood flow (TBF) of hepatocellular carcinoma (HCC) with a noninvasive method using xenon inhalation CT (xenon-CT) and to differentiate between well-differentiated HCCs and moderately and poorly differentiated HCCs. Materials and Methods: Total, arterial and portal venous TBFs of 38 surgically proven HCC nodules from 38 patients were measured by means of xenon-CT. Serial abdominal CT scans were obtained before and after inhalation of nonradioactive xenon gas. TBF was computed using the Fick principle, after which the correlation between TBF and pathologic features of the tumors was determined. Results: Total, arterial, and portal venous TBFs of HCC were 125.7 +/- 59.9 mL/min/100g, 102.5 +/- 37.3, and 22.2 +/- 11.4, respectively, and the corresponding findings for hepatic parenchyma were 67.3 +/- 13.1, 25.2 +/- 9.6, and 42.4 +/- 11.0. Total and arterial TBFs of HCC were significantly higher than those of the hepatic parenchyma (P < 0.01), whereas portal venous TBF of HCC was significantly lower than that of hepatic parenchyma (P < 0.01). Arterial TBF of moderately or poorly differentiated HCC (120.4 +/- 38.2) was significantly higher than that of well-differentiated HCC (60.4 +/- 43.5) (P < 0.01). Conclusions: Arterial and portal venous TBFs of HCC could be measured separately, noninvasively, and safely with xenon-CT. Correlation between TBF and pathologic features of tumors indicate that xenon-CT can be used to differentiate between well-differentiated HCCs and moderately and poorly differentiated HCCs.
    LIPPINCOTT WILLIAMS & WILKINS, 2004年04月, INVESTIGATIVE RADIOLOGY, 39(4) (4), 210 - 215, 英語

  • PS-126-6 Perfusion CT(Deconvolution法)による肝組織血流量測定の検討
    橋本 和彦, 堂野 恵三, 左近 賢人, 丸橋 繁, 宮本 敦史, 永野 浩昭, 梅下 浩司, 中森 正二, 堀 雅俊, 村上 卓道, 工藤 正幸, 中村 仁信, 門田 守人
    一般社団法人日本外科学会, 2004年03月15日, 日本外科学会雑誌, 105, 536 - 536, 日本語

  • 鉄とリピオドールを含んだCT,MRI両用造影剤の試作-ウサギ肝での実験
    桑原 雅知, 村上 卓道, 堀 雅敏, Natsag J, 大西 裕満, Fahrni M, Khankan A, 安部 久志, 河田 修治, 中田 早紀, 大須賀 慶悟, 金 東石, 中村 仁信, 宇山 宏和, 友田 要, 高橋 哲, 鳴海 善文
    (公社)日本医学放射線学会, 2004年03月, 日本医学放射線学会雑誌, 64(3) (3), 167 - 167, 日本語

  • 当院における高吸水性ポリマーSAP‐MSを用いたUAEの初期検討
    坪山尚寛, 大須賀慶悟, アッザム カンカン, 河田修治, 中田早紀, 友田要, 村上卓道, 中村仁信, 堀信一
    (公社)日本医学放射線学会, 2004年02月25日, 日本医学放射線学会雑誌, 64(2) (2), S238 - S238, 日本語

  • Deconvolution法を用いたCT perfusion解析ソフトによる肝動脈,門脈血流の分離定量的評価
    村上卓道, 堀雅敏, 金東石, 大須賀慶悟, 友田要, 中村仁信, 工藤正幸
    (公社)日本医学放射線学会, 2004年02月25日, 日本医学放射線学会雑誌, 64(2) (2), S103 - S103, 日本語

  • 門脈の発達異常に伴う肝内門脈の欠損・低形成の画像診断
    金東石, 安部久志, 村上卓道, 堀雅敏, 大須賀慶悟, 友田要, 中田早紀, 桑原雅知, 大西裕満
    (公社)日本医学放射線学会, 2004年02月25日, 日本医学放射線学会雑誌, 64(2) (2), S283 - S283, 日本語

  • 横隔膜原発のlocalized fibrous tumorの一例
    東原 大樹, 上田 忠, 三原 直樹, 金 東石, 野中 健太郎, 尹 亨亮, 築山 正嗣, 今北 正美, 河田 修治, 友田 要, 村上 卓道, 中村 仁信
    (公社)日本医学放射線学会, 2004年01月, 日本医学放射線学会雑誌, 64(1) (1), 67 - 67, 日本語

  • 妊娠時に偶然発見され,嚢胞性腫瘤を呈した腎嫌色素細胞癌の一例
    桑原 雅知, 堀 雅敏, 中田 早紀, 大須賀 慶悟, 村上 卓道, 友田 要, 中村 仁信, 鳴海 善文, 高橋 哲, 三宅 修, 辻本 裕一, 青笹 克之
    (公社)日本医学放射線学会, 2004年01月, 日本医学放射線学会雑誌, 64(1) (1), 69 - 69, 日本語

  • 肝腫瘍の診断ストラテジー肝特異性MRI造影剤をどう活用する？
    工藤 正俊, 泉 並木, 村上卓道
    2004年, Rad Fan, 2(7) (7), 2 - 8

  • 肝細胞癌治療の進歩：動注
    大須賀慶悟, 村上 卓道
    2004年, 癌と化学療法, 31, 2114 - 2117

  • びまん性肝疾患とその病態診断：肝硬変を含む
    大西裕満, 村上 卓道
    2004年, 臨床放射線, 49, 1393 - 1401

  • 新しい子宮筋腫治療とその問題点：子宮筋腫のMR guided Focused Ultrasound治療
    村上 卓道, 三上恒治
    2004年, 産婦人科の世界, 56, 959 - 966

  • MRガイド下Focused Ultrasound治療
    村上 卓道, 三上恒治
    2004年, 映像情報Medical, 36, 1104 - 1109

  • MDCT of the abdomen: 腹部領域におけるMDCTの臨床応用
    村上 卓道
    2004年, Innervision Innervision, 19, 114 - 115

  • Step up MRI 2004:領域別MRIの位置づけ:肝臓
    中田早紀, 村上 卓道
    2004年, Innervision Innervision, 19, 11 - 14

  • CTパーフュージョン
    橋本和彦, 村上 卓道
    2004年, 臨床画像, 20, 1058 - 1064

  • 肝癌の局所治療：集束超音波療法
    三上恒治, 村上 卓道
    2004年, 消化器内視鏡, 16, 625 - 630

  • MRガイド下集束超音波治療
    村上 卓道, 三上恒治
    2004年, Medical Science Digest Medical Science Digest, 30, 368 - 372

  • Real time navigation surgery using 3D CT in laparoscopic gastric surgery
    S Takiguchi, M Sekimoto, M Hiroshi, Y Fujiwara, T Yasuda, M Yano, M Hori, T Murakami, H Nakamura, M Monden
    Laparoscopic surgery has enabled to perform minute operation through the enlarged visual field, and aggressively promoted lymph node dissection surgery which has been considered complicated so far. On the other hand, it was clarified that it has difficulty in grasping anatomy due to the enlarged visual field. We have integrated CT technology and computer technology and developed the technique to convert real time 3D CT to the visual field from the same angle as that of endoscopic field during surgery, which has been used in the clinical setting. This system enables ensured lymph node dissection by proceeding surgery, grasping the anatomy. Endoscopic surgery has the feature of constant monitoring in performing surgery, thus it has environment facilitating to refer to image information using the submonitor. Hereafter, by spread of such supporting system, more ensured surgery will be carried out.
    MEDIMOND PUBLISHING CO, 2004年, PROCEEDINGS OF THE 9TH WORLD CONGRESS OF ENDOSCOPIC SURGERY, 69 - 76, 英語

  • T Murakami, M Hori, T Kim, S Kawata, H Abe, H Nakamura
    It is important to diagnose hepatocellular carcinoma (HCC) correctly and in early stage, because viral hepatitis and liver cirrhosis are often complicated by HCC. Non-contrast and enhanced CT and MRI are very useful to visualize and diagnose HCC objectively. Especially, CT and MR imaging with dynamic study is essential to diagnose HCC, because it is usually hypervascular. Dynamic CT and MR study also improve differential diagnosis in the characterization of the tumor. However, to perform useful dynamic study, it is necessary to use a CT unit which can make a helical scan, or a MR system with fast imaging technique available that can obtain more than 15 slices within a single breath hold. Tissue specific contrast medium, such as superparamagnetic iron oxide that is available only on MRI, is also useful for diagnosis of HCC. Copyright (C) 2004 S. Karger AG, Basel.
    KARGER, 2004年, INTERVIROLOGY, 47(3-5) (3-5), 209 - 226, 英語

  • M Hori, T Murakami, T Kim, K Tomoda, H Nakamura
    Computed tomography (CT) and magnetic resonance imaging (MRI) are useful for detection and characterization of liver tumors, and widely used in clinical practice. By using dynamic CT and MRI with extracellular contrast material or MRI with liver-specific contrast material, we can investigate the morphological, hemodynamical and functional nature of focal hepatic lesions. Tumors often show characteristic findings on CT and MRI. Thus, we can correctly establish a diagnosis of liver tumors based on those findings. In this article, we describe the role of CT scan and MRI in the differentiation of liver tumors as well as presenting some typical CT and MR images. Copyright (C) 2004 S. Karger AG, Basel.
    KARGER, 2004年, DIGESTIVE DISEASES, 22(1) (1), 39 - 55, 英語
    書評論文,書評,文献紹介等

  • 肝細胞癌診断におけるDynamic Multidetector CTの撮像法
    村上 卓道, 金 東石
    2004年, 映像情報Medical, 36, 786 - 372

  • 大腸画像診断の進歩：その他の画像診断：MDCT,MRI,PET,SPIOなど
    村上 卓道, 堀 雅敏
    2004年, 外科治療, 91, 12 - 20

  • 転移性肝腫瘍患者におけるフェルカルボトラン造影MRIの使用経験：マルチスライスCTとの比較
    村上 卓道, 堀 雅敏
    2004年, 日獨医報, 49, 23 - 31

  • TAEと動注化学療法
    中村仁信, 村上 卓道
    2004年, Medico, 35, 136 - 138

  • 肝・胆・膵腫瘍の診断：マルチスライスCTを中心に
    金 東石, 村上 卓道
    2004年, 日磁医誌, 24, 16 - 23

  • マルチスライスCT血管造影
    村上 卓道
    2004年, Clinician Clinician, 51, 329 - 335

  • PET画像診断での3D、フュージョンイメージング
    堀 雅敏, 村上 卓道
    2004年, 新医療, 31(3) (3), 88 - 90

  • 腹空鏡下手術における3D CTによるリアルタイムナビゲーションサージェリー
    瀧口修司, 村上 卓道
    2004年, 外科治療, 90(1) (1), 21 - 27

  • 子宮筋腫に対するMR下集束超音波治療 (MR guided focused ultrasound therapy)
    村上 卓道, 岡田篤哉
    2004年, 映像情報, 35, 70 - 75

  • Motion sensor を用いた腹腔鏡手術用 3D CT simulation および Real time navigation surgery の有用性について
    瀧口 修司, 関本 貢嗣, 宮田 博志, 藤原 義之, 安田 卓司, 矢野 雅彦, 堀 雅敏, 村上 卓道, 中村 仁信, 桝本 潤, 佐藤 嘉信, 田村 進一, 門田 守人
    2003年12月30日, Journal of Japan Society of Computer Aided Surgery : J.JSCAS, 5(3) (3), 325 - 326, 日本語

  • 肝胆膵のCT angiography (特集 ここまでわかる消化器疾患の三次元画像アトラス)
    村上 卓道, 金 東石, 堀 雅敏
    永井書店, 2003年11月, 外科治療 = Surgical therapy : 外科系臨床雑誌, 89(5) (5), 499 - 506, 日本語

  • 65.腹腔鏡下胃癌リンパ節郭清におけるピットフォールとその対策 : 3D CT angiographyを用いた術中Navigation(再建術式とその機能評価(V))(第32回胃外科・術後障害研究会)
    瀧口 修司, 関本 貢嗣, 藤原 義之, 安田 卓司, 矢野 雅彦, 堀 雅敏, 村上 卓道, 門田 守人
    一般社団法人日本消化器外科学会, 2003年09月01日, 日本消化器外科学会雑誌, 36(9) (9), 1356 - 1356, 日本語

  • T Murakami, T Kim, S Kawata, M Kanematsu, MP Federle, M Hori, A Okada, S Kumano, E Sugihara, K Tomoda, H Nakamura
    Purpose: We evaluated the optimal timing of arterial phase imaging for detection of hypervascular hepatocellular carcinoma by using triple arterial phase imaging with multi detector-row helical computed tomography. Materials and Methods: Forty-nine patients with 90 hypervascular hepatocellular carcinomas (3 to 50 mm in diameter; mean, 18.7 mm) under-went triple arterial phase imaging of the whole liver using a multidetector-row helical computed tomography. At 20 seconds, 30 seconds, and 40 seconds after intravenous administration of 100 mL of 300 mgI/mL of nonionic contrast medium at a rate of 4 mL/s, early, middle, and late arterial phase images were obtained serially during a single breath-hold with an interscan delay of 5 seconds. Detector-row configurations of 4 mm x 4, scan pitch of 5.5, and scan time of 5 seconds for each phase were used. Forty prospective reconstruction images of 5-mm thickness for each phase were obtained. The images from each phase were interpreted separately for detection of hypervascular hepatocellular carcinoma by 3 observers independently who were unaware of tumor burden in the liver. Sensitivity, positive predictive value, and area under the receiver operating characteristic curve values for each arterial phase were calculated and compared statistically. Results: The mean sensitivity and positive predictive values for hypervascular hepatocellular carcinoma diagnosis of blind readers were 37% and 87% for the early arterial phase, 73% and 85% for the middle arterial phase, and 49% and 81% for the late arterial phase, respectively. The middle arterial phase imaging showed significantly superior sensitivity compared with the early and late arterial phase for detecting hepatocellular carcinoma (P < 0.05). Mean area under the receiver operating characteristic curve value of the middle arterial phase imaging (0.84) was significantly higher that that of the early (0.56) or late arterial phase (0.62; P < 0.05). Conclusion: If a single arterial phase is used for diagnosis of hypervascular hepatocellular carcinoma, the middle phase (delay time of 30 seconds) is optimal.
    LIPPINCOTT WILLIAMS & WILKINS, 2003年08月, INVESTIGATIVE RADIOLOGY, 38(8) (8), 497 - 503, 英語

  • 次世代の画像解析ソフトウェア 治療に役立つ腹部MDCT三次元画像
    村上卓道, 堀雅敏, 大須賀慶悟, 友田要, 中村仁信, 金東石
    2003年07月, Innervision, 18(7) (7), 16 - 17, 日本語

  • E Sugihara, T Murakami, T Kim, M Hori, M Takamura, S Kawata, A Okada, AA Khankan, K Tomoda, H Nakamura
    Purpose: The technique of double-phase echo chemical shift gradient-echo magnetic resonance (MR) imaging with the fast low-angle shot sequence (double-echo FLASH) provides in-phase and opposed-phase (double-phase) images simultaneously. The purpose of this study was to assess whether the dynamic study with a combination of in-phase and opposed-phase (double-phase) echo images improves the detectability of hypervascular hepatocellular carcinoma (HCC) compared with that with either in-phase or opposed-phase images alone. Method: Thirty-seven patients with 107 hypervascular HCCs who underwent the whole-liver double-phase echo dynamic MR imaging were enrolled in the study. Three radiologists blindly read in-phase images alone, opposed-phase images alone, and then double-phase images together. Sensitivity and positive predictive values as well as the areas below the alternative-free response receiver operating characteristic curve (Az values) for each imaging technique were calculated and compared statistically. Results: The mean sensitivity, positive predictive values, and Az values for hypervascular HCCs were 51%, 77%, and 0.52 for in-phase imaging; 55%, 86%, and 0.58 for opposed-phase imaging; and 57%, 84%, and 0.63 for double-phase imaging, respectively. The mean sensitivity for opposed-phase imaging was significantly higher than that for in-phase imaging (P < 0.05), and the mean sensitivity for double-phase imaging was higher than that for in-phase imaging (P < 0.01). The mean Az value for the double-phase imaging was significantly higher than that for in-phase imaging (P < 0.01). Conclusion: Dynamic MR imaging with double-phase images was recommended for the detection of hypervascular HCC.
    LIPPINCOTT WILLIAMS & WILKINS, 2003年03月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 27(2) (2), 110 - 116, 英語

  • Deconvolution法を用いたCT perfusion 解析ソフトによる肝動脈,門脈血流の分離定量的評価
    村上卓道, 堀雅敏, 河田修治, 杉原栄治, 中田早紀, 大須賀慶悟, 金東石, 中村仁信, 工藤正幸
    (公社)日本医学放射線学会, 2003年02月25日, 日本医学放射線学会雑誌, 63(2) (2), S130 - S130, 日本語

  • 8列型マルチディテクターCTを用いたCT angiographyによる上腹部領域の動脈描出能
    河田修治, 堀雅敏, 杉原英治, 大須賀慶悟, 中田早紀, 桑原雅知, 中村仁信, 村上卓道, 金東石
    (公社)日本医学放射線学会, 2003年02月25日, 日本医学放射線学会雑誌, 63(2) (2), S190-S191 - S191, 日本語

  • 躯幹部CT用呼吸同期システムの試作
    堀雅敏, 河田修治, 杉原栄治, 中田早紀, 大須賀慶悟, 中村仁信, 村上卓道, 金東石, 工藤正幸
    (公社)日本医学放射線学会, 2003年02月25日, 日本医学放射線学会雑誌, 63(2) (2), S212 - S212, 日本語

  • 超音波凝固療法：肝細胞癌に対する経皮的MCT
    石田 毅, 村上 卓道
    2003年, Radiology Frontier Radiology Frontier, 6, 265 - 268

  • 堀 雅俊, 村上 卓道
    2003年, 消化器画像, 5, 816 - 823

  • 肝胆膵のCT angiography
    村上 卓道, 金 東石
    2003年, 外科治療, 89, 499 - 506

  • 腹部のマルチスライスCT（上腹部を中心に）
    金 東石, 村上 卓道
    2003年, 日本医学放射線学会雑誌, 63, 369 - 377

  • 上腹部・骨盤部領域のマルチスライスCT：上腹部領域での応用
    金 東石, 村上 卓道
    2003年, 日獨医報, 48, 200 - 208

  • 肝 マルチスライスCTによる肝疾患の診断
    堀 雅敏, 村上 卓道
    2003年, Innervision Innervision, 18(3) (3), 68 - 72

  • 肝の絨毛性前腸嚢胞:Ciliated foregut cyst of the liver
    村上 卓道, 中村 仁信
    2003年, Clinician Clinician, 51, 213 - 217

  • High flow AVMに対する血管内治療の役割と外科治療との関わり
    大須賀 慶悟, 岡田 篤哉, 杉浦 考司, 前田 宗広, 村上 卓道, 中村 仁信, 細川 亙, 川崎 富夫, 堀 信一, 北吉 光
    血管外科症例検討会, 2002年12月, 血管外科, 21(1) (1), 184 - 184, 日本語

  • Evaluation of arterial stenosis of lower extremities with multidetector-row CT angiography (MDCTA): Comparison to conventional digital subtraction angiography (DSA)
    E Sugihara, T Kim, S Kawata, S Kumano, T Murakami, H Nakamura
    RADIOLOGICAL SOC NORTH AMERICA, 2002年11月, RADIOLOGY, 225, 160 - 160, 英語
    研究発表ペーパー・要旨（国際会議）

  • Quantitative assessment of each histological grade of hepatocellular carcinoma tissue blood flow with xenon-enhanced CT
    E Sugihara, T Murakami, S Hayashi, K Dono, K Tomoda, H Nakamura
    RADIOLOGICAL SOC NORTH AMERICA, 2002年11月, RADIOLOGY, 225, 392 - 392, 英語
    研究発表ペーパー・要旨（国際会議）

  • High spatial resolution hepatic CT microangiography with a synchrotron radiation system: Experimental study with rats
    M Hori, S Kobayashi, T Murakami, K Umetani, M Monden, H Nakamura
    RADIOLOGICAL SOC NORTH AMERICA, 2002年11月, RADIOLOGY, 225, 391 - 391, 英語
    研究発表ペーパー・要旨（国際会議）

  • Usefulness of newly developed interactive multiplanar reconstruction viewer for large amount of image sets by multidetector-row CT: Evaluation of invasion to surrounding organs by esophageal carcinoma
    T Johkoh, T Murakami, S Yamamoto, O Honda, H Nakamura, T Amano
    RADIOLOGICAL SOC NORTH AMERICA, 2002年11月, RADIOLOGY, 225, 548 - 548, 英語
    研究発表ペーパー・要旨（国際会議）

  • Multidetector CT angiography of upper abdominal arteries using an eight-detector row CT scanner
    S Kawata, T Murakami, T Kim, M Hori, K Tomoda, H Nakamura
    RADIOLOGICAL SOC NORTH AMERICA, 2002年11月, RADIOLOGY, 225, 353 - 353, 英語
    研究発表ペーパー・要旨（国際会議）

  • Evaluation of renal arteries in living renal donors: Comparison of the accuracy of contrast-enhanced CT angiography using multidetector-row helical CT and gadolinium-enhanced MR angiography using 3D Fourier transformation gradient echo
    T Kim, T Murakami, S Takahashi, M Hori, M Takamura, H Nakamura
    RADIOLOGICAL SOC NORTH AMERICA, 2002年11月, RADIOLOGY, 225, 348 - 349, 英語
    研究発表ペーパー・要旨（国際会議）

  • Y Noguchi, T Murakami, T Kim, M Hori, K Osuga, S Kawata, A Okada, T Sugiura, K Tomoda, Y Narumi, H Nakamura
    Purpose: The technique of double-echo chemical shift gradient echo magnetic resonance imaging (MRI) With the fast low-angle shot (double-echo FLASH) sequence provides in-phase and opposed-phase images in a single breath hold. The purpose of this study was to evaluate the efficacy of dynamic MRI with double-echo FLASH imaging for the detection of hypervascular hepatocellular carcinoma by comparing it With dynamic helical computed tomography (CT) imaging With double arterial phase. Materials and Methods: Twenty-nine patients with 67 hypervascular hepatocellular carcinoma nodules Who underwent both dynamic MRI with double-echo FLASH imaging (repetition time/echo time/flip angle: 160/3.6, 7.0/80degrees) and dynamic helical CT imaging with double arterial phase were enrolled in the study. For dynamic MRI, precontrast, arterial. portal venous, and equilibrium phase images were obtained before and approximately 19, 60, and 120 seconds, respectively, after intravenous injection of 0.1 mmol/kg of gadopentetate dimeglumine at a rate of 2 ml/s. For dynamic CT imaging, quadraphase images, including early arterial, late arterial, portal venous, and equilibrium phases, were obtained serially approximately 20, 30, 70, and 180 seconds, respectively, after intravenous administration of 2 ml/kg of 300 mgl/ml of nonionic contrast medium at a rate of 5 ml/s. Three masked observers independently interpreted images obtained With each technique in random order, separately and without patient identifiers. Sensitivity and positive predictive values as well as the area below the alternative-free response receiver operating characteristic curve (Az) for each imaging technique were calculated and compared statistically. Results: Mean sensitivity and positive predictive values of MRI for hypervascular hepatocellular carcinoma Were 48% and 94%, respectively, and those of CT imaging were 47% and 91%, respectively. In 11 (38%) of the 29 patients, at least one observer judged dynamic MRI to be superior, whereas in 5 patients (17%), dynamic CT was judged to be superior. There was no significant difference in the sensitivity and positive predictive values between these techniques (p > 0.05). There was no significant difference either in mean Az values between CT (0.55) and MRI (0.57) (p = 0.61). Conclusion: Dynamic MRI with double-echo FLASH imaging can detect hypervascular hepatocellular carcinoma as well as dynamic helical CT imaging with double arterial phase.
    LIPPINCOTT WILLIAMS & WILKINS, 2002年11月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 26(6) (6), 981 - 987, 英語

  • 肝細胞癌と胆管細胞癌の同時重複癌の1例
    安部久志, 村上卓道, 金東石, 大須賀慶悟, 堀雅敏, 河田修治, 杉原英治, 友田要, 中村仁信
    (公社)日本医学放射線学会, 2002年10月01日, 日本医学放射線学会雑誌, 62(11) (11), S385 - S385, 日本語

  • M Hori, T Murakami, T Kim, K Tsuda, S Takahashi, A Okada, M Takamura, H Nakamura
    Purpose: The purpose of this study was to compare the diagnostic performance of superparamagnetic iron oxide (SPIO)-enhanced MRI for the detection of hypervascular hepatocellular carcinoma (HCC) with dynamic helical CT. Methods: SPIO-enhanced MR and dynamic helical CT images obtained from 41 patients with 52 hypervascular HCCs (5-130 mm; mean, 27 mm) were retrospectively analyzed. MRI were obtained with 1.5 T scanners using T2-weighted and proton density-weighted spin-echo (or fast spin-echo) sequences for all cases and a T2*-weighted gradient echo sequence for 36 cases. Four blinded observers reviewed images independently. Diagnostic accuracy was evaluated using alternative-free response receiver operating characteristic (AFROC) method. Sensitivities and positive predictive values (PPV) were also evaluated. Results: The areas under the AFROC curves for each observer were greater for MR than for CT (means, 0.81 and 0.76; p < 0.05). The mean sensitivities for MR and CT were 0.75 and 0.71, respectively (p = 0.13). The mean PPVs were 0.83 and 0.79 (p = 0.21). Conclusion: SPIO-enhanced MRI showed slightly better diagnostic performance than dynamic helical CT for the detection of hypervascular HCCs.
    LIPPINCOTT WILLIAMS & WILKINS, 2002年09月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 26(5) (5), 701 - 710, 英語

  • Multidetector CT: Diagnostic impact of slice thickness on detection of hypervascular hepatocellular carcinoma
    S Kawata, T Murakami, T Kim, M Hori, MP Federle, S Kumano, E Sugihara, S Makino, H Nakamura, M Kudo
    OBJECTIVE. The objective of our study was to evaluate the diagnostic impact of varying slice thickness on multidetector CT to optimize detection of hypervascular hepatocellular carcinoma. MATERIALS AND METHODS. Forty-three patients with 87 hypervascular hepatocellular carcinomas (diameter: range, 3-80 mm; mean, 22 mm) and 19 patients with either chronic hepatitis or liver cirrhosis and without hepatocellular carcinoma who had undergone early arterial and late arterial phase imaging of the entire liver on multidetector CT were retrospectively enrolled in this study. The detector row configuration was 2.5 x 4 mm, the pitch was 6, and the scanning time was 10.5 sec for each phase. All patients received contrast medium (2 mL/kg of body weight) at a rate of 5 mL/sec; the mean scanning delay for the early arterial phase was 19.0 sec, and the mean delay for the late arterial phase was 34.5 sec. Eighty 2.5-mm-thick reconstruction images, forty 5-mm-thick reconstruction images, and twenty-six 7.5-mm-thick reconstruction images were obtained for each phase. Each image set was interpreted separately by three observers to detect hypervascular hepatocellular carcinoma by viewing images on a workstation monitor. Sensitivity, positive predictive value, and area under the receiver operating characteristic curve (A(z)) were calculated. We used retrospectively excellent follow-up and imaging or pathologic proof as the gold standard. RESULTS. The mean sensitivity and positive predictive value for hypervascular hepatocellular carcinoma were 76% and 69% on 2.5-mm images, 73% and 69% on 5-mm, images, and 67% and 76% on 7.5-mm images, respectively. No significant difference in sensitivity among the images was detected, except by one observer who reported a significant difference in the sensitivity between 2.5- and 7.5-mm images (p < 0.05) and between 5- and 7.5-mm images (p < 0.05). The mean A(z) values were 0.79, 0.80, and 0.78 for 2.5-, 5-, and 7.5-mm images, respectively. No significant difference in A(z) values among the images obtained with different slice thicknesses was detected. CONCLUSION. For multidetector CT identification of hypervascular hepatocellular carcinoma, we found little or no advantage in reducing slice thickness to less than 5 mm.
    AMER ROENTGEN RAY SOC, 2002年07月, AMERICAN JOURNAL OF ROENTGENOLOGY, 179(1) (1), 61 - 66, 英語

  • 胆道閉鎖症術後患児に生じた孤立性胃静脈りゅうに対するバルーン閉塞下逆行性経静脈的静脈りゅう塞栓術(BRTO)の経験
    佐々木隆士, 長谷川利路, 木村拓也, 岡田正, 村上卓道, 杉浦孝司
    2002年05月20日, 日本小児外科学会雑誌, 38(3) (3), 483, 日本語

  • The diagnostic value of Tl-201 SPECT in bronchioloalveolar lung carcinoma (BAC).
    M Miyagawa, Sakamoto, I, N Tomiyama, T Murakami, S Hosoi, T Mochizuki, J Ikezoe
    SOC NUCLEAR MEDICINE INC, 2002年05月, JOURNAL OF NUCLEAR MEDICINE, 43(5) (5), 300P - 300P, 英語
    研究発表ペーパー・要旨（国際会議）

  • Small hypervascular hepatocellular carcinoma revealed by double arterial phase CT performed with single breath-hold scanning and automatic bolus tracking
    T Kim, T Murakami, M Hori, M Takamura, S Takahashi, A Okada, S Kawata, M Cruz, MP Federle, H Nakamura
    OBJECTIVE. The purpose of this study was to evaluate the usefulness of double arterial phase CT for the detection of small hypervascular hepatocellular carcinomas, using an automated bolus-tracking technique to initiate the hepatic arterial phase CT. MATERIALS AND METHODS. Double arterial and late phase contrast-enhanced helical CT scans were obtained on 287 consecutive patients suspected of having hepatocellular carcinoma. These included 56 patients with 90 small (less than or equal to3 cm) hepatocellular carcinomas and 50 patients with no hepatocellular carcinomas. CT scans of these patients were interpreted by three reviewers. The first arterial phase scan was initiated automatically 10 sec after the bolus-tracking program detected the threshold enhancement of 50 H in the abdominal aorta. Three. reviewers interpreted the late phase CT scans in combination with the first, second, or both hepatic arterial phases. Measures of the reviewers detection of hepatocellular carcinoma included analysis of interobserver variation, sensitivity, specificity, and area under receiver operating characteristic curve (A(z)). RESULTS. The time elapsed from bolus initiation to threshold aortic enhancement ranged from 10 to 24 sec (mean, 13 see), resulting in initiation of the first arterial phase CT scan from 20 to 34 see (mean, 23 see). The combination of late phase CT and both first and second arterial phase images showed significantly better performance than the combination of the late phase and either the first or second arterial phases, although the difference was most evident in comparison with the combination of second arterial and late phases. CONCLUSION. An automated bolus-tracking program can be used to optimize the timing of hepatic arterial phase CT. Multiphasic CT performed using this technique is useful in detection of small hepatocellular carcinoma.
    AMER ROENTGEN RAY SOC, 2002年04月, AMERICAN JOURNAL OF ROENTGENOLOGY, 178(4) (4), 899 - 904, 英語

  • Xenon CTによる膵腫瘍組織血流量
    久保田 勝, 堂野 恵三, 林 昇甫, 金 東石, 加藤 友朗, 永野 浩昭, 梅下 浩司, 中森 正二, 村上 卓道, 左近 賢人, 門田 守人
    一般社団法人日本外科学会, 2002年03月10日, 日本外科学会雑誌, 103, 612 - 612, 日本語

  • Lapview 3D angio CTを用いた術中Navigationによる腹腔鏡下手術
    瀧口 修司, 関本 貢嗣, 藤原 義之, 安田 卓司, 田村 茂行, 矢野 雅彦, 熊野 正士, 金 東石, 村上 卓道, 門田 守人
    一般社団法人日本外科学会, 2002年03月10日, 日本外科学会雑誌, 103, 689 - 689, 日本語

  • Multislice CTとautomatic bolus trackingを用いた肝のdouble arterial phase CT
    KIM T, 村上卓道, 河田修治, 安部久志, 堀雅敏, 熊野正士, 岡田篤哉, 大須賀慶悟, 中村仁信
    (公社)日本医学放射線学会, 2002年03月10日, 日本医学放射線学会雑誌, 62(3) (3), S58-S59 - S59, 日本語

  • 放射光を用いた3D肝脈管微細構造描出の試み
    小林 省吾, 堂野 恵三, 堀 雅敏, 梅谷 啓二, 上杉 健太郎, 新井 勲, 近藤 礎, 永野 浩昭, 梅下 浩司, 中森 正二, 左近 賢人, 村上 卓道, 大須賀 慶悟, 中村 仁信, 門田 守人
    一般社団法人日本外科学会, 2002年03月10日, 日本外科学会雑誌, 103(0) (0), 日本語

  • T Murakami, T Kim, S Takahashi, H Nakamura
    SPRINGER-VERLAG, 2002年03月, ABDOMINAL IMAGING, 27(2) (2), 139 - 146, 英語

  • Percutaneous microwave tumor coagulation for hepatocellular carcinomas with interruption of segmental hepatic blood flow
    T Ishida, T Murakami, T Shibata, Y Inoue, M Takamura, T Niinobu, T Sato, H Nakamura
    PURPOSE: To assess the effect of hepatic artery occlusion with or without hepatic venous outflow interruption on coagulation diameter during percutaneous microwave coagulation therapy (PMCT) for hepatocellular carcinoma (HCC) by a prospective and randomized trial. MATERIALS AND METHODS: Thirty-one patients with 36 HCCs (10-38 mm in diameter) were randomly separated into two treatment groups as follows: group 1 (14 tumors in 14 patients) was treated with PMCT in conjunction with both segmental hepatic artery embolization with gelatin sponge particles and temporary interruption of hepatic venous flow by means of a 6-F balloon catheter to reduce the portal venous flow; group 2 (22 tumors in 17 patients) was treated with PMCT with segmental hepatic artery embolization only. PMCT under ultrasound (US) guidance was performed with 2,450 MHz of microwave frequency at 40-60 W and a needle applicator 1.6 mm in diameter. The coagulated area was measured at the maximum diameter perpendicular to the needle tract on enhanced computed tomography (CT) performed immediately after PMCT. The local effect of the treatment was evaluated by follow-up enhanced CT (6-33 mo). RESULTS: Patients in group I had a significantly larger coagulation area (mean +/- SD = 42.9 mm +/- 8.3), with coagulation times of 5.3 min +/- 1.4, than patients in group 2 (32.6 mm +/- 8.0), with coagulation times of 4.2 min +/- 1.3 (P <.05). Follow-up enhanced CT showed no local enhancement of the tumor, indicating complete necrosis and no local recurrence, except for four tumors. There were no major complications after PMCT except liver abscess that developed after PMCT in one patient with pneumobilia. CONCLUSIONS: PMCT with combined hepatic arterial embolization and temporary hepatic venous flow interruption can coagulate significantly larger volumes of tumor than PMCT with only hepatic arterial embolization.
    LIPPINCOTT WILLIAMS & WILKINS, 2002年02月, JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 13(2) (2), 185 - 191, 英語

  • MRIガイド下血管系IVRシステム In vivoにおけるcatheter tracking study
    安部久志, 村上卓道, 黒田輝, 熊本悦子, 岡田篤哉, BILGIN K, AZZAM K, 堀雅敏, 中村仁信
    2002年, 日本医学放射線学会雑誌, 62(3) (3)

  • Multi-detector row helical CT angiography of hepatic vessels: Depiction with dual-arterial phase acquisition during single breath hold
    S Takahashi, T Murakami, M Takamura, T Kim, M Hori, Y Narumi, H Nakamura, M Kudo
    PURPOSE: To determine by using multi-detector row computed tomography (CT), in a triphasic hepatic dynamic study, which included single breath-hold dual-arterial phase acquisition, the accuracy and frequency of visualization of the small hepatic arterial and portal venous anatomy with angiographic correlation. MATERIALS AND METHODS: In 62 patients, pre- and postcontrast triphasic helical CT were performed by using a multi-detector row CT scanner, with 2.5-mm detector row collimation, at a pitch of 6. The first and second arterial phases were performed during a single breath hold. One reader, blinded to the results of the angiography, reviewed the first arterial phase images on a cine display to assess hepatic arterial anatomy. Visualization of the portal vein and its branches was assessed by using second arterial and portal venous phase images. RESULTS: Major arterial trunks (celiac, hepatic, superior mesenteric, and left gastric) were depicted in all cases. Visualization of small arteries was as follows: right and left hepatic, 62 (100%) of 62; middle hepatic, 52 (87%) of 60; cystic, 47 (90%) of 52; right gastric, 50 (89%) of 56; and right and left inferior phrenic, 57 (92%) and 55 (89%) of 62 respectively Subsegmental or more peripheral branches of the portal vein were depicted in 83% of cases during the second arterial phase and in 96% during the portal phase. There was no difference in degree of visualization in these two phases. CONCLUSION: Multi-detector row CT angiography was able to depict the hepatic vascular anatomy.
    RADIOLOGICAL SOC NORTH AMERICA, 2002年01月, RADIOLOGY, 222(1) (1), 81 - 88, 英語

  • Masatoshi Hori, Takamichi Murakami, Tonsok Kim, Hironobu Nakamura
    Both computed tomography arterial portography (CTAP) and CT hepatic arteriography (CTHA) are CT techniques with angiographic assistance. The detection sensitivity of these techniques is high because marked lesion contrast can be obtained using direct delivery of contrast materials to the liver parenchyma or the tumors. The use of CTAP and CTHA may improve therapeutic results after transarterial embolization therapy for hepatocellular carcinomas because of their high diagnostic accuracy. Findings on CTAP or CTHA can sometimes help characterize the hepatic focal lesions. Thus, CTAP and CTHA are frequently performed as pretreatment examinations, although they are invasive compared to intravenous (IV) contrast-enhanced CT or magnetic resonance imaging. However, there are some potential pitfalls, such as nontumorous perfusion abnormalities. CTAP and CTHA are less effective for evaluation of patients with cirrhosis and portal hypertension. This article presents a current overview of CTAP and CTHA technique for diagnosis of hepatic neoplasms. Copyright 2002, Elsevier Science (USA). All rights reserved.
    W.B. Saunders, 2002年, Techniques in Vascular and Interventional Radiology, 5(3) (3), 164 - 169, 英語
    書評論文,書評,文献紹介等

  • 肝造影ＣＴ検査におけるイオパミドールの臨床評価 ?体重比用量群と固定用量群との多施設比較試験-
    山本和宏, 村上 卓道
    2002年, 日獨医報, 47, 549 - 568

  • 治療に役立つ腹部Multidetector-row helical CT (MDCT)三次元画像
    村上 卓道, 堀 雅敏
    2002年, Innervision Innervision, 17(12) (12), 44 - 45

  • 肝・胆・膵の画像診断
    金 東石, 村上 卓道
    2002年, 総合臨床, 51, 1443 - 1447

  • MRIの肝組織特異性造影剤
    村上 卓道
    2002年, Radiology Frontier Radiology Frontier, 5, 271 - 274

  • 腹部領域：肝の造影MRI
    村上 卓道
    2002年, Innervision Innervision, 17, 20 - 25

  • 腹部領域におけるマルチスライスCT診断
    村上 卓道, 金 東石
    2002年, 映像情報Medical, 34, 117 - 124

  • 堀 雅俊, 村上 卓道
    2002年, 臨床婦人科学, 56, 612 - 615

  • マルチディテクターCT：撮像, 再構成そして読影：肝臓領域
    金 東石, 村上 卓道
    2002年, 臨床画像, 18, 534 - 542

  • 異なる時相間におけるCT腹部肝臓領域の非剛体レジストレーションの検討
    桝本 潤, 村上 卓道
    2002年, 信学技報, 89, 59 - 64

  • 映像による治療支援のあるべき姿
    中村仁信, 村上 卓道
    2002年, 映像情報, 34, 434 - 437

  • New technique of embolic coil placement for exclusion of the splenic artery aneurysms
    M Maeda, K Osuga, Y Morita, A Okada, T Murakami, H Nakamura
    RADIOLOGICAL SOC NORTH AMERICA, 2001年11月, RADIOLOGY, 221, 202 - 202, 英語
    研究発表ペーパー・要旨（国際会議）

  • Supplementary value of multi-shot and single-shot fast SE imaging in ferumoxide-enhanced MR imaging for detection of malignant hepatic tumors. Observer performance study using McNemar's test and ROC analysis for clustered data
    M Matsuo, M Kanematsu, T Murakami, M Hori, M Takamura, H Hoshi
    RADIOLOGICAL SOC NORTH AMERICA, 2001年11月, RADIOLOGY, 221, 401 - 401, 英語
    研究発表ペーパー・要旨（国際会議）

  • Detection of hypervascular hepatocellular carcinoma with dynamic MR imaging: Which is best - Opposed-phase, in-phase, or double-phase gradient-echo MR imaging?
    E Sugihara, T Murakami, T Kim, M Hori, M Takamura, H Nakamura
    RADIOLOGICAL SOC NORTH AMERICA, 2001年11月, RADIOLOGY, 221, 305 - 305, 英語
    研究発表ペーパー・要旨（国際会議）

  • Magnetic compression anastomosis of the vascular system in experimental dog models: Feasibility study
    T Sugiura, E Yamanouchi, T Murakami, H Nakamura
    RADIOLOGICAL SOC NORTH AMERICA, 2001年11月, RADIOLOGY, 221, 415 - 415, 英語
    研究発表ペーパー・要旨（国際会議）

  • Preoperative evaluation of living renal donors: Comparison of multidetector-row helical CT angiography and 3D MR angiography
    T Kim, T Murakami, S Takahashi, M Takamura, Y Narumi, H Abe
    RADIOLOGICAL SOC NORTH AMERICA, 2001年11月, RADIOLOGY, 221, 633 - 633, 英語
    研究発表ペーパー・要旨（国際会議）

  • Double arterial phase imaging of the liver with use of multidetector-row helical CT and automatic bolus tracking technique
    T Kim, T Murakami, M Hori, S Kawata, S Kumano, H Nakamura
    RADIOLOGICAL SOC NORTH AMERICA, 2001年11月, RADIOLOGY, 221, 490 - 490, 英語
    研究発表ペーパー・要旨（国際会議）

  • Quantitative assessment of hepatic tumor tissue blood flow with Xenon-enhanced CT
    T Murakami, J Shimizu, S Hayashi, T Kim, K Dono, H Nakamura
    RADIOLOGICAL SOC NORTH AMERICA, 2001年11月, RADIOLOGY, 221, 576 - 576, 英語
    研究発表ペーパー・要旨（国際会議）

  • Quantitative assessment of hepatic damage by measuring the hepatic tissue blood flow with Xenon-enhanced CT
    T Murakami, S Hayashi, M Takamura, T Kim, K Dono, H Nakamura
    RADIOLOGICAL SOC NORTH AMERICA, 2001年11月, RADIOLOGY, 221, 496 - 496, 英語
    研究発表ペーパー・要旨（国際会議）

  • Effect of iodine concentration of contrast material on vascular enhancement and contrast of hypervascular hepatocelluar carcinoma in patients with chronic liver disease
    T Kim, T Murakami, E Sugihara, M Hori, S Kawata, H Nakamura
    RADIOLOGICAL SOC NORTH AMERICA, 2001年11月, RADIOLOGY, 221, 576 - 577, 英語
    研究発表ペーパー・要旨（国際会議）

  • Breath-hold T2-weighted imaging of hepatic lesions by using fast recovery, fast spin-echo sequence
    T Kim, T Murakami, S Takahashi, M Hori, M Takamura, H Nakamura
    RADIOLOGICAL SOC NORTH AMERICA, 2001年11月, RADIOLOGY, 221, 304 - 305, 英語
    研究発表ペーパー・要旨（国際会議）

  • A newly developed Xenon CT imaging for separately measurement of the hepatic arterial and portal venous tissue blood flow: An animal study
    S Hayashi, T Murakami, J Shimizu, M Takamura, K Dono, H Nakamura
    RADIOLOGICAL SOC NORTH AMERICA, 2001年11月, RADIOLOGY, 221, 110 - 110, 英語
    研究発表ペーパー・要旨（国際会議）

  • 腎移植後の合併症に対して血管内治療が有用であった1症例
    KAHNKAHN A, 前田宗宏, 牧野茂, 岡田篤哉, 大須賀慶悟, 杉浦孝司, 村上卓道, 中村仁信
    (一社)日本インターベンショナルラジオロジー学会, 2001年10月31日, IVR, 16(4) (4), 383 - 383, 日本語

  • Fat suppressed 3Dgradient echo法を用いたdynamic MRIとdynamic helical CTの肝細胞癌検出能の比較
    野口由美, 村上卓道, 金東石, 堀雅敏, 高村学, 大須賀慶悟, 河田修治, 杉原英治, 中村仁信
    (公社)日本医学放射線学会, 2001年10月25日, 日本医学放射線学会雑誌, 61(12) (12), 707 - 707, 日本語

  • Fat suppressed 3D gradient echo法を用いたdynamic MRIとdynamic helical CTの肝細胞癌検出能の比較
    野口由美, 村上卓道, 金東石, 堀雅敏, 大須賀慶悟, 河田修治, 杉浦孝司, 岡田篤哉, 中村仁信
    断層映像研究会, 2001年09月30日, 断層映像研究会雑誌, 28(3) (3), 166 - 166, 日本語

  • 放射光を用いた肝動脈・門脈のReal Time Micro‐angiographyの試み
    小林省吾, 堂野恵三, 新井勲, 近藤礎, 左近賢人, 堀雅俊, 大須賀慶悟, 村上卓道, 門田守人
    2001年09月25日, 肝臓, 42(Supplement 2) (Supplement 2), A444, 日本語

  • Fat suppressed 3D gradient echo法を用いたdynamic MRIとdynamic helical CTの肝細胞癌検出能の比較
    野口由美, 村上卓道, 金東石, 堀雅敏, 高村学, 大須賀慶悟, 河田修治, 杉原英治, 中村仁信
    2001年09月20日, 日本磁気共鳴医学会雑誌, 21(Supplement) (Supplement), 166, 日本語

  • Pancreatic mass due to chronic pancreatitis: Correlation of CT and MR imaging features with pathologic findings
    T Kim, T Murakami, M Takamura, M Hori, S Takahashi, S Nakamori, M Sakon, Y Tanji, K Wakasa, H Nakamura
    OBJECTIVE. The purpose of this study was to identify helical CT and MR imaging features of pancreatic masses (focal enlargement) due to chronic pancreatitis and their correlation with pathologic findings. CONCLUSION. When histologic fibrosis is uniformly present through the pancreas in patients with chronic pancreatitis, there is no demarcation of masses due to chronic pancreatitis. When there is a greater degree of histologic fibrosis in the masslike part of the pancreas. the mass is often demarcated from the remaining pancreas, and the enhancement pattern on two-phase helical CT and dynamic gadolinium-enhanced MR imaging mimics that of pancreatic adenocarcinoma.
    AMER ROENTGEN RAY SOC, 2001年08月, AMERICAN JOURNAL OF ROENTGENOLOGY, 177(2) (2), 367 - 371, 英語

  • PP212050 Xenon CTを用いた膵組織血流量測定
    久保田 勝, 堂野 恵三, 林 昇甫, 高村 学, 金 東石, 永野 浩昭, 梅下 浩司, 中森 正二, 村上 卓道, 左近 賢人, 中村 仁信, 門田 守人
    一般社団法人日本消化器外科学会, 2001年07月01日, 日本消化器外科学会雑誌, 34(7) (7), 1103 - 1103, 日本語

  • PP104110 Xenon CTによる肝組織血流測定法で生体部分肝移植後のグラフト肝梗塞を診断し得た一例
    林 昇甫, 堂野 恵三, 左近 賢人, 久保田 勝, 永野 浩昭, 中森 正二, 梅下 浩司, 高村 学, 村上 卓道, 中村 仁信, 門田 守人
    一般社団法人日本消化器外科学会, 2001年07月01日, 日本消化器外科学会雑誌, 34(7) (7), 966 - 966, 日本語

  • 末梢動脈りゅうに対するコイル塞栓手技に関する実験的検討
    前田宗宏, 大須賀慶悟, 岡田篤哉, 杉浦孝司, 村上卓道, 中村仁信
    2001年07月01日, IVR, 16(3) (3), 278, 日本語

  • 循環器の画像診断ガイド IV.疾患の画像診断 11.大静脈疾患 2)Budd‐Chiari症候群
    前田宗宏, 大須賀慶悟, 村上卓道, 中村仁信
    2001年05月30日, 綜合臨床, 50, 1746 - 1752, 日本語

  • DSMの基礎と臨床 スフェレックスを用いた肝血流遮断下マイクロウェーブ腫瘍凝固療法
    高村 学, 村上 卓道, 岡田 篤哉, 大須賀 慶悟, 金 東石, 中村 仁信, 永野 浩昭, 中森 正二, 堂野 恵三, 左近 賢人
    (株)メディカルレビュー社, 2001年05月, Radiology Frontier, 4(2) (2), 162 - 162, 日本語

  • Microwave coagulation therapy with interruption of hepatic blood in- or outflow: An experimental study
    M Takamura, T Murakami, T Shibata, T Ishida, T Niinobu, S Kawata, J Shimizu, T Kim, M Monden, H Nakamura
    PURPOSE: To determine how interruption of hepatic blood in- or outflow affects the coagulation diameter of microwave coagulation therapy (MCT) in the liver. MATERIALS AND METHODS: Laparotomic MCT at 60 W for 1 minute was performed in 11 Landrace pigs. MCT was performed under six different conditions: without occlusion (Group N; in seven lobes of seven pigs); with occlusion of the hepatic artery (Group A; in five lobes of five pigs); with occlusion of the portal vein (Group P;in five lobes of five pigs); with occlusion of the hepatic artery and portal vein (Group AP; in six lobes of six pigs); with occlusion of the hepatic vein (Group V; in five lobes of four pigs); and with occlusion of the hepatic artery and vein (Group AV; in seven lobes of seven pigs). The maximum diameters for each group were compared. RESULTS: The coagulation diameters (mean +/- SD) were 8.5 mm +/- 2.0, 10.0 mm +/- 1.6, 14.3 mm +/- 2.5, 14.4 mm +/- 2.4, 13.0 mm +/- 0.8, and 14.4 mm +/- 1.5 for Groups N, A, P,AP, V, and AV, respectively. The coagulation diameters for groups P, AP, V, and AV were statistically larger than those for groups N and A (P < .05). There was no significant difference between the coagulation diameters of Groups P, AP, V, and AV. CONCLUSION: The coagulation diameter depends mainly on the portal venous flow. In addition of direct interruption of the portal vein, interruption of the hepatic vein can also result in a substantial increase in the coagulation diameter.
    LIPPINCOTT WILLIAMS & WILKINS, 2001年05月, JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 12(5) (5), 619 - 622, 英語

  • T Murakami, K Mochizuki, H Nakamura
    Because recent advances in medical care decrease the mortality rate due to liver cirrhosis itself, many cirrhotic patients die due to hepatocellular carcinoma. Accordingly, the role of radiology in the evaluation of the patient with cirrhosis is primarily to characterize the morphologic manifestations of the disease, evaluate the hepatic and extrahepatic vasculature, assess the effects of portal hypertension, and detect hepatic tumors. When the latter are identified, a critical role of imaging technology is to differentiate hepatocellular carcinoma from other nodular lesions, such as dysplastic nodules and regenerating nodules. Screening strategies for patients with cirrhosis have been proposed to facilitate the detection of small, asymptomatic hepatocellular carcinomas. Dynamic studies using computed tomography (CT) and magnetic resonance imaging (MRI) are very useful for the diagnosis of hepatic tumors previously detected by ultrasound, as well as for screening. In Japan, patients with documented cirrhosis typically undergo serum alpha-fetoprotein testing and/or PIVKA-II (protein induced by Vitamin K absence or antagonist II) measurements every 2 months, ultrasound every 3 months, and CT or MRI every 6 months. This has resulted in great success in detecting small hepatocellular carcinomas (less than 2 cm in diameter) and early-stage well-differentiated hepatocellular carcinomas.
    THIEME MEDICAL PUBL INC, 2001年05月, SEMINARS IN LIVER DISEASE, 21(2) (2), 213 - 224, 英語
    書評論文,書評,文献紹介等

  • 肝切除後の胆管閉塞に対する山内法の経験
    杉浦孝司, 岡田篤哉, 大須賀慶悟, 村上卓道, 中村仁信, 山内栄五郎
    (公社)日本医学放射線学会, 2001年04月25日, 日本医学放射線学会雑誌, 61(5) (5), 253 - 253, 日本語

  • 2歳幼児に対するTIPSの経験
    岡田篤哉, 村上卓道, 前田宗宏, 大須賀慶悟, 高橋哲, 杉浦孝司, 河田修治, 中村仁信, 中村健治
    (一社)日本インターベンショナルラジオロジー学会, 2001年04月01日, IVR, 16(2) (2), 191 - 192, 日本語

  • コイルアンカー併用コイル塞栓術が有効であった医原性大動脈・下大静脈ろうの1例
    前田宗宏, 中田早紀, 保本卓, 岡田篤哉, 河田修治, 大須賀慶悟, 杉浦孝司, 村上卓道, 中村仁信
    2001年04月01日, IVR, 16(2) (2), 189, 日本語

  • PP1396 膵腫瘍血流測定に対する新しい試み : Xenon CTを用いた膵組織血流量測定法を用いて
    久保田 勝, 林 昇甫, 堂野 恵三, 永野 浩昭, 中森 正二, 梅下 浩司, 高村 学, 金 東石, 村上 卓道, 左近 賢人, 中村 仁信, 門田 守人
    一般社団法人日本外科学会, 2001年03月10日, 日本外科学会雑誌, 102, 572 - 572, 日本語

  • PP1134 肝線維化の進行度と肝組織血流量の関係 : Xenon CTを用いた肝動脈門脈組織血流量分別測定法を用いて
    林 昇甫, 堂野 恵三, 左近 賢人, 久保田 勝, 永野 浩昭, 中森 正二, 梅下 浩司, 高村 学, 金 東石, 村上 卓道, 若狭 研一, 中村 仁信, 門田 守人
    一般社団法人日本外科学会, 2001年03月10日, 日本外科学会雑誌, 102, 507 - 507, 日本語

  • 胆道閉鎖症術後の難治性消化管出血例に対する経頚静脈的肝内門脈静脈短絡術(TIPS)の試み
    長谷川利路, 木村拓也, 佐々木隆士, 岡田正, 村上卓道, 中村健治
    2001年03月10日, 日本外科学会雑誌, 102, 56, 日本語

  • Hypervascular hepatocellular carcinoma: Detection with double arterial phase multi-detector row helical CT
    T Murakami, T Kim, M Takamura, M Hori, S Takahashi, MP Federle, K Tsuda, K Osuga, S Kawata, H Nakamura, M Kudo
    PURPOSE: To assess whether double arterial phase imaging with multi-detector row helical computed tomography improves detection of hypervascular hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Fifty-one patients with 96 hypervascular HCCs underwent double arterial phase imaging of the entire liver. At measured delay after intravenous administration of 2 mL/kg of contrast medium at a rate of 5 mL/sec, the early and late arterial phase images were obtained serially during a single breath hold with interscan delay of 5.0 seconds. Detector row configuration of 2.5 x 4 mm, pitch of 6, and scanning time of 10.5 seconds for each phase were used. Forty 5-mm-thick reconstruction images were obtained for each phase. Each image set was interpreted separately by three observers, who were unaware of tumor burden in the liver, to detect hypervascular HCC. Sensitivity, positive predictive value, and area below the receiver operating characteristic curve (A(z)) for early and late arterial phases separately and together were calculated. RESULTS: Mean sensitivity and positive predictive value for hypervascular HCC were 54% and 85% for the early arterial phase, 78% and 83% for the late arterial phase, and 86% and 92% for the double arterial phase, respectively. Double arterial phase imaging showed significantly superior sensitivity compared with early or late arterial phase imaging alone for detecting HCC (P < .05). The mean A(z) value for double arterial phase was significantly higher than that for early or late arterial phase imaging alone (P < .05). Double arterial phase imaging showed the lowest number of false-positive lesions. CONCLUSION: Double arterial phase imaging is recommended to improve detection of hypervascular HCCs and reduce false-positive lesions.
    RADIOLOGICAL SOC NORTH AMER, 2001年03月, RADIOLOGY, 218(3) (3), 763 - 767, 英語

  • 血管奇形に対するOpen‐MRIガイド下硬化療法の臨床的有用性と問題点
    大須賀慶悟, 岡田篤哉, 杉浦孝司, 杉原英治, 前田宗宏, 村上卓道, 中村仁信, 堀信一, 高田晃一
    (公社)日本医学放射線学会, 2001年02月20日, 日本医学放射線学会雑誌, 61(2) (2), S245-S246 - S246, 日本語

  • 肝のmulti‐phasic CTにおける高濃度造影剤の効果
    金東石, 杉原英治, 村上卓道, 堀雅敏, 高村学, 河田修治, 岡田篤哉, 大須賀慶悟, 中村仁信
    (公社)日本医学放射線学会, 2001年02月20日, 日本医学放射線学会雑誌, 61(2) (2), S44 - S44, 日本語

  • T Murakami, T Kim, M Takamura, J Shimizu, M Hori, K Dono, K Takachi, N Kato, T Miyazawa, M Sakon, M Monden, H Nakamura
    The purpose of this study was to investigate whether regional liver damage could be detected by means of enhanced MR imaging with a superparamagnetic iron oxide (SH U 555A) in an ischemia-reperfusion model of rat liver. Ischemic liver damage was induced in the right lobe by vascular clamping for 0 (sham), 30 (I-30), 60 (I-60), and 90 minutes (I-90), There was no significant difference in relative enhancement (RE) between the ischemic and nonischemic lobes in the sham, I-30 and I-60 groups, while RE of the ischemic lobe was significantly lower than that of its nonischemic counterpart in the I-90 group as seen on SH U 555A enhanced proton density spin echo images (P < 0.05). Histological examination revealed that iron deposits were significantly smaller in the ischemic than the nonischemic lobe in the I-90 group (P < 0.05), although there was no significant difference in the number of Kupffer cells. Our results indicate that severe regional liver damage can be evaluated by MR imaging with SH U 555A.
    KLUWER ACADEMIC/PLENUM PUBL, 2001年01月, DIGESTIVE DISEASES AND SCIENCES, 46(1) (1), 148 - 155, 英語

  • Double arterial phase multi-detector row helical CT in diagnosis of hepatocellular carcinoma.
    村上 卓道
    2001年, Medical Imaging International, 11, 14 - 16

  • 肝脾の造影CTでの造影剤注入法
    村上 卓道
    2001年, 日本医事新報, 4060, 114 - 115

  • 新しい塞栓物質SAP-microsphere
    大須賀慶悟, 村上 卓道
    2001年, 日本臨床, 59, 534 - 538

  • 肝のMRI（撮像法と造影剤）
    村上 卓道
    2001年, 日磁医誌, 21, 251 - 2634

  • ＣＴ体積データからの肝臓領域抽出ソフト: Liver CT Analyzer
    堀 雅敏, 村上 卓道
    2001年, Innervision Innervision, 16(12) (12), 62 - 64

  • 肝臓の立体データ
    堀 雅敏, 村上 卓道
    2001年, Medical Technology Medical Technology, 29(12) (12), 1272 - 1274

  • 三次元画像診断, CT. 腹部：肝, 胆, 膵, 脾, 門脈
    金 東石, 村上 卓道
    2001年, 総合臨床, 50(11) (11), 3096 - 3012

  • 腹部造影MDCTの再新動向
    村上 卓道, 中村仁信
    2001年, 新医療, 322, 102 - 105

  • マルチスライスCTとの比較におけるMRIの有用性:肝臓
    野口由美, 村上 卓道
    2001年, Innervision Innervision, 16(9) (9), 28 - 31

  • エキスパートによるRSNA最新リポート 1. MRIの最新技術と臨床応用の動向：腹部を中心に
    堀 雅敏, 村上 卓道
    2001年, Innervision Innervision, 16(3) (3), 11 - 12

  • マルチスライスCTの臨床応用：肝臓疾患への応用
    村上 卓道, 金 東石
    2001年, 臨床画像, 17, 306 - 313

  • 限局性結節性過形成
    金 東石, 村上 卓道
    2001年, 消化器画像, 3, 17 - 20

  • Helical high-resolution CT by multidetector-row CT system in the paracardiac lung areas: Decrease of cardiac motion artifact by using multisector reconstruction under ECG gating
    T Johkoh, T Murakami, Y Narumi, H Nakamura, K Sasaki, M Kudo
    RADIOLOGICAL SOC NORTH AMER, 2000年11月, RADIOLOGY, 217, 438 - 438, 英語
    研究発表ペーパー・要旨（国際会議）

  • Double arterial phase imaging with use of half-second helical CT and automatic bolus tracking technique for detecting small hypervascular hepatocellular carcinoma
    T Kim, T Murakami, M Hori, M Takamura, S Takahashi, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 2000年11月, RADIOLOGY, 217, 369 - 369, 英語
    研究発表ペーパー・要旨（国際会議）

  • Microwave coagulation therapy with interruption of hepatic in- or out-flow: An experimental study
    M Takamura, T Murakami, T Shibata, T Ishida, J Shimizu, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 2000年11月, RADIOLOGY, 217, 539 - 540, 英語
    研究発表ペーパー・要旨（国際会議）

  • Systematically-built CT angiography of the hepatic and pancreatic vessels: Comparison of maximum intensity projection images, volume rendering images, and axial source images with conventional digital subtraction angiography
    S Kawata, T Kim, M Takamura, S Takahashi, T Murakami, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 2000年11月, RADIOLOGY, 217, 417 - 417, 英語
    研究発表ペーパー・要旨（国際会議）

  • Single vs half dose contrast enhanced three-dimensional MR angiography for the abdominal aorta and pelvis
    S Takahashi, T Kim, T Murakami, M Hori, M Takamura, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 2000年11月, RADIOLOGY, 217, 132 - +, 英語
    研究発表ペーパー・要旨（国際会議）

  • New technique on GDA coil method catheter placement for hepatic arterial chemoinfusion therapy: Initial clinical experience
    M Maeda, A Okada, K Osuga, S Kawata, T Murakami, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 2000年11月, RADIOLOGY, 217, 378 - 378, 英語
    研究発表ペーパー・要旨（国際会議）

  • Evaluation of optimal timing of the arterial phase imaging for the detection of hypervascular hepatocellular carcinoma by using triple arterial phase imaging of multidetector-row helical CT
    T Murakami, T Kim, S Takahashi, M Hori, M Takamura, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 2000年11月, RADIOLOGY, 217, 367 - 367, 英語
    研究発表ペーパー・要旨（国際会議）

  • Multidetector row helical CT angiography of the pancreatic vessels
    S Takahashi, T Kim, M Takamura, M Hori, T Murakami, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 2000年11月, RADIOLOGY, 217, 541 - 541, 英語
    研究発表ペーパー・要旨（国際会議）

  • ECG triggering high-resolution CT by 0.5-second/rotation multidetector-row CT: The decreasing of cardiac motion artifact and the precise evaluation of the extent of ground-glass attenuation of idiopathic pulmonary fibrosis
    T Johkoh, S Yamamoto, N Tomiyama, T Murakami, Y Narumi, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 2000年11月, RADIOLOGY, 217, 124 - 124, 英語
    研究発表ペーパー・要旨（国際会議）

  • Technical optimization of multi-detector helical CT for depicting renal arterial stenosis: A phantom study
    S Takahashi, S Yamamoto, M Kudo, M Takamura, T Murakami, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 2000年11月, RADIOLOGY, 217, 107 - 107, 英語
    研究発表ペーパー・要旨（国際会議）

  • Automatic liver segmentation for dynamic helical CT images: An effective technique by using two-phase volume data
    M Hori, J Masumoto, Y Sato, T Murakami, S Tamura, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 2000年11月, RADIOLOGY, 217, 208 - 208, 英語
    研究発表ペーパー・要旨（国際会議）

  • Usefulness of MR cholangiography with volume rendering: Receiver-operating-characteristic curve analysis in patients with cholelithiasis
    H Kondo, M Kanematsu, K Itoh, T Murakami, M Hori, H Hoshi
    RADIOLOGICAL SOC NORTH AMER, 2000年11月, RADIOLOGY, 217, 170 - 170, 英語
    研究発表ペーパー・要旨（国際会議）

  • 胆道閉鎖症術後2才児の難治性消化管出血に対する頚静脈的肝内門脈静脈短絡術(TIPS)の経験
    帆足孝也, 長谷川利路, 木村拓也, 佐々木隆士, 村上卓道, 岡田正
    2000年09月30日, 肝臓, 41(Supplement 2) (Supplement 2), A401, 日本語

  • 進行肝癌(Stage IV‐A)に対する治療法の選択 その適応と限界について 動注化学塞栓療法(TAE)の適応と限界について
    中村仁信, 河田修治, 高村学, 大須賀慶悟, 村上卓道
    肉眼的進行度がStage III以上の肝細胞癌症例に対しては,腫瘍の広がりや高度の血管侵襲のために手術不能となることが多く,肝動脈塞栓療法(TAE)や動注化学療法といった経カテーテル的療法を中心とした治療がとられることが多い.TAEは反復して施行できる点で,進行肝癌の治療に有効である.ただし,肉眼的分類の違いにより,その治療方針は異なり,腫瘍が結節型で被膜を有していれば,TAEのよい適応となるが,塊状型では結節型ほどの治療効果は期待できない.全肝に対するTAEが不可能な肝予備能の低い症例に対しても,マイクロカテーテル等の開発により超選択的カテーテル法が可能になりTAEの適応が拡大してきている
    (株)癌と化学療法社, 2000年09月15日, 癌と化学療法, 27(10) (10), 1509 - 1515, 日本語

  • Superparamagnetic iron oxide-enhanced magnetic resonance images of hepatocellular carcinoma: Correlation with histological grading
    Y Imai, T Murakami, S Yoshida, M Nishikawa, M Ohsawa, K Tokunaga, M Murata, K Shibata, S Zushi, M Kurokawa, T Yonezawa, S Kawata, M Takamura, H Nagano, M Sakon, M Monden, K Wakasa, H Nakamura
    Superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging has been used for the detection of hepatic tumors. However, little is known about this technique in relation to hepatocellular carcinoma (HCC). The aim of this study was to investigate whether SPIO-enhanced MR imaging can be useful in assessing histological grades of HCC. The authors studied histologically proven tumors including 31 HCCs and 6 dysplastic nodules. The ratio of the Kupffer-cell count in the tumorous tissue relative to that in the nontumorous tissue (Kupffer-cell-count ratio) decreased as HCCs became less well differentiated. The ratio of the intensity of the tumorous lesion to that of the nontumorous area on SPIO-enhanced MR images (SPIO intensity ratio) correlated inversely with Kupffer-cell-count ratio in HCCs and dysplastic nodules (r = -.826, P < .001) and increased as the degree of differentiation of HCCs decreased, indicating that the uptake of SPIO in HCCs decreased as the degree of differentiation of HCCs declined. All of the dysplastic nodules and some well-differentiated HCCs showed hypointense or isointense enhancement, relative to the surrounding liver parenchyma, indicating greater or similar uptake of SPIO in the tumor when compared with nontumorous areas, These results suggest that SPIO-enhanced MR imaging reflects Kupffer-cell numbers in HCCs and dysplastic nodules, and is useful for estimation of histological grading in HCCs, although uncertainties persist in differentiating dysplastic nodules from well-differentiated HCCs.
    W B SAUNDERS CO, 2000年08月, HEPATOLOGY, 32(2) (2), 205 - 212, 英語

  • マルチスライスCT画像からの肝臓領域自動抽出
    桝本 潤, 佐藤 嘉伸, 堀 雅敏, 村上 卓道, 上甲 剛, 中村 仁信, 田村 進一
    2000年07月25日, Medical imaging technology, 18(4) (4), 405 - 406, 日本語

  • PP95 Xe/CTによる肝組織血流量測定の有用性 : 胆道癌および膵癌での検討
    清水 潤三, 堂野 恵三, 左近 賢人, 林 昇甫, 高村 学, 村上 卓道, 永野 浩昭, 中森 正二, 梅下 浩司, 岡 博史, 中村 仁信, 門田 守人
    一般社団法人日本消化器外科学会, 2000年07月01日, 日本消化器外科学会雑誌, 33(7) (7), 1031 - 1031, 日本語

  • PP1420 Xenon CTを用いた肝組織血流測定による肝切除術後の高ビリルビン血症の予測
    林 昇甫, 堂野 恵三, 清水 潤三, 永野 浩昭, 中森 正二, 梅下 浩司, 左近 賢人, 高村 学, 村上 卓道, 中村 仁信, 門田 守人
    一般社団法人日本消化器外科学会, 2000年07月01日, 日本消化器外科学会雑誌, 33(7) (7), 1252 - 1252, 日本語

  • Multishot echo-planar imaging with gadopentetate dimeglumine - Preliminary study of efficacy for detection of hypovascular metastatic liver tumors
    T Murakami, T Kim, M Hori, M Takamura, K Tsuda, S Takahashi, Y Narumi, H Nakamura
    Objective: To evaluate the usefulness of sequential T2-weighted spin-echo type multishot echo-planar (T2-EP) imaging with gadopentetate dimeglumine for the detection of hypovascular metastatic liver tumors. Material and Methods. Fifteen consecutive patients with 56 proven hypovascular metastatic liver tumors were included in the study. Three observers blindly and independently read the whole-liver images obtained with T2-weighted spin-echo, T2-weighted single-shot fast spin-echo, T1-weighted fast multiplanar spoiled GRASS and T3-EP images obtained before and 25, 60, 90 and 120 s after injection of 0.2 mmol/kg b.w. of gadopentetate dimeglumine. The diagnostic accuracy was estimated by calculating the area under the observer-specific binomial receiver operating characteristics curves (Az). Results. T2-EP images obtained 60 s after contrast injection showed significantly higher contrast-to-noise (C/N) ratios than the other imaging techniques. A combination of all phases of the T2-EP images produced the highest sensitivity and specificity. In terms of the Az value, the diagnostic accuracy for tumor detection achieved with a combination of all phases of the T2-EP images was significantly higher than that with T1-SPGR and T2-SSFSE images (p<0.01). The Az values of the T2-EP images (Az=0.975) were higher than those of T2-CSE images (Az=0.948), but the difference was not significant. Conclusion: Our preliminary study revealed that sequential imaging with enhanced T2-EP images was useful for the detection of hypovascular metastatic liver tumors because of its superior CM ratio and sensitivity.
    MUNKSGAARD INT PUBL LTD, 2000年05月, ACTA RADIOLOGICA, 41(3) (3), 263 - 268, 英語

  • Single breath-hold T2-weighted MR imaging of the liver: Value of single-shot fast spin-echo and multishot spin-echo echoplanar imaging
    M Hori, T Murakami, T Kim, M Kanematsu, K Tsuda, S Takahashi, M Takamura, H Hoshi, H Nakamura
    OBJECTIVE. The objective of our study was to evaluate the efficacy of single breath-hold T2-weighted MR imaging for detection of focal hepatic lesions. MATERIALS AND METHODS. T2-weighted MR images were retrospectively reviewed from 51 patients with 85 solid and 59 nonsolid lesions using the following four sequences: conventional spin-echo, respiratory-triggered fast spin-echo, single-shot fast spin-echo, and multishot spin-echo echoplanar imaging. Images were reviewed on a hepatic segment-by-seg ment basis; T2-weighted images of a total of 408 hepatic segments were reviewed separately and independently for solid and nonsolid lesions by four radiologists. Quantitative, qualitative, and receiver operating characteristic analyses were performed. RESULTS. For solid lesions, no significant differences were seen among the lesion-to-liver contrast-to-noise ratios with the four sequences. In terms of solid lesion detection, no significant difference was seen between the diagnostic accuracy of multishot spin-echo echoplanar (A(z) = 0.90) and respiratory-triggered fast spin-echo (A(z) = 0.91) imaging, which showed the best performance of the four sequences. For nonsolid lesion detection, respiratory-triggered fast spin-echo and single-shot fast spin-echo imaging were judged the best (A(z) = 0.94). CONCLUSION. Breath-hold single-shot fast spin-echo and multishot spin-echo echoplanar sequences can be substituted for conventional spin-echo and respiratory-triggered fast spin-echo T2-weighted sequences.
    AMER ROENTGEN RAY SOC, 2000年05月, AMERICAN JOURNAL OF ROENTGENOLOGY, 174(5) (5), 1423 - 1431, 英語

  • Preoperative detection of malignant hepatic tumors: Comparison of combined methods of MR imaging with combined methods of CT
    H Kondo, M Kanematsu, H Hoshi, T Murakami, T Kim, M Hori, M Matsuo, H Nakamura
    OBJECTIVE, We compared radiologists' performance on combined unenhanced, gadolinium-enhanced, and ferumoxides-enhanced MR imaging with their performance on helical CT during arterial portography (CTAP) and biphasic CT during hepatic arteriography (CTHA) for the preoperative detection of malignant hepatic rumors. SUBJECTS AND METHODS. MR images and CT scans obtained in 33 patients were retrospectively analyzed. Images of the liver were reviewed on a segment-by-segment basis; a total of 261 segments with 39 hepatocellular carcinomas and 21 metastases were independently reviewed by three radiologists who were invited from outside institutions. Unenhanced and gadolinium-enhanced MR images were reviewed first, then ferumoxides-enhanced MR images were added for combined review. CTAP images and biphasic CTHA images were reviewed together. RESULTS. Sensitivity for the detection of hepatic tumors was analogous for combined unenhanced gadolinium-enhanced, and ferumoxides-enhanced MR images (86%) and for combined CTAP images and biphasic CTHA images (87%). Specificity was higher with MR images (95%, p < 0.01) than with CT images (91%). Radiologists' performances were improved (A(z) = 0.962, p = 0.0502) by combining ferumoxides-enhanced MR images with unenhanced and gadolinium-enhanced MR images (A(z) = 0.950), and were analogous for combined unenhanced, gadolinium-enhanced, and ferumoxides-enhanced MR images and for combined CTAP images and biphasic CTHA images (A(z) = 0.959). CONCLUSION. Radiologists' performances on combined unenhanced, gadolinium-enhanced, and ferumoxides-enhanced MR imaging compared with their performances on combined helical CTAP and biphasic CTHA are analogous for the preoperative detection of malignant hepatic tumors. Such a dedicated combination of MR imaging may obviate the need for more invasive angiographically assisted helical CT for the preoperative detection of malignant hepatic tumors.
    AMER ROENTGEN RAY SOC, 2000年04月, AMERICAN JOURNAL OF ROENTGENOLOGY, 174(4) (4), 947 - 954, 英語

  • 日本の医療経済からみた肝のCT,MR診断
    村上 卓道
    2000年03月01日, 日本磁気共鳴医学会雑誌, 20(2) (2), 64 - 72, 日本語

  • M Sakon, H Nagano, J Shimizu, M Kondo, S Nakamori, K Dono, K Umeshita, H Nakamura, T Murakami, M Monden
    WILEY-LISS, 2000年03月, JOURNAL OF SURGICAL ONCOLOGY, 73(3) (3), 179 - 181, 英語

  • リザーバー留置(DGAcoil法,SpAcoil法)の新しい手技の開発 コイルアンカーとスリット状側孔の検討
    前田 宗宏, 岡田 篤哉, 河田 修治, 高村 学, 大須賀 慶悟, Cruz Modesto, 村上 卓道, 大井 博道, 中村 仁信, 村田 昌之
    (公社)日本医学放射線学会, 2000年02月, 日本医学放射線学会雑誌, 60(2) (2), S128 - S128, 日本語

  • 肝・胆・すい疾患における画像診断の進歩とIVR 2. 原発性肝細胞癌のIVRのこれまでと将来
    村上卓道, 河田修治, 大須賀慶悟, 中村仁信
    2000年01月01日, IVR, 15(1) (1), 16 - 21, 日本語

  • Multidetector row helical CT angiography of the hepatic vessel: Separate depiction of hepatic arterial, portal, and venous anatomy
    S Takahashi, T Murakami, T Kim, M Takamura, Y Narumi, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 1999年11月, RADIOLOGY, 213P, 126 - 126, 英語
    研究発表ペーパー・要旨（国際会議）

  • Automated detection of focal hepatic lesions in abdominal CT images
    M Hori, J Masumoto, Y Sato, T Murakami, T Johkoh, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 1999年11月, RADIOLOGY, 213P, 365 - 365, 英語
    研究発表ペーパー・要旨（国際会議）

  • Preoperative detection of hepatic tumors: Comparison of combined unenhanced T1-and T2-weighted, gadolinium-enhanced triphasic, and ferumoxides-enhanced MR vs combined CTAP and biphasic CTHA
    H Kondo, M Kanematsu, H Hoshi, T Murakami, T Kim, M Hori
    RADIOLOGICAL SOC NORTH AMER, 1999年11月, RADIOLOGY, 213P, 171 - 171, 英語
    研究発表ペーパー・要旨（国際会議）

  • Clinical late phase III trials of multihance (Gd-BOPTA) for the MR imaging of liver tumors in Japan: Comparison with magnevist
    R Kuwatsuru, M Kadoya, K Ohtomo, A Tanimoto, S Hirohashi, T Murakami
    RADIOLOGICAL SOC NORTH AMER, 1999年11月, RADIOLOGY, 213P, 339 - 339, 英語
    研究発表ペーパー・要旨（国際会議）

  • FSE hepatic lesion detection with T2-weighted MR images: Supplementary value of fat-suppressed halt-fourier single-shot FSE vs multishot SE EP images to fat-suppressed respiratory-triggered FSE images
    M Matsuo, M Kanematsu, H Hoshi, T Murakami, T Kim, M Hori
    RADIOLOGICAL SOC NORTH AMER, 1999年11月, RADIOLOGY, 213P, 428 - 428, 英語
    研究発表ペーパー・要旨（国際会議）

  • The usefulness of double arterial phase imaging of multislice helical CT for the detection of hypervascular hepatocellular carcinoma
    T Murakami, T Kim, S Takahashi, M Takamura, Y Narumi, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 1999年11月, RADIOLOGY, 213P, 126 - 126, 英語
    研究発表ペーパー・要旨（国際会議）

  • Multidetector row helical CT angiography of the renal vessel: Usefulness of single breath-hold dual-phase acquisition
    S Takahashi, T Kim, M Takamura, Y Narumi, T Murakami, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 1999年11月, RADIOLOGY, 213P, 432 - 432, 英語
    研究発表ペーパー・要旨（国際会議）

  • 肝疾患に用いるMRI高速撮像法と応用
    村上 卓道, 堀 雅敏, 金 東石, 中村 仁信
    1999年09月01日, 日本磁気共鳴医学会雑誌, 19(6) (6), 399 - 414, 日本語

  • Effects of injection rates of contrast material on arterial phase hepatic CT - Reply
    T Kim, T Murakami, H Nakamura
    AMER ROENTGEN RAY SOC, 1999年07月, AMERICAN JOURNAL OF ROENTGENOLOGY, 173(1) (1), 238 - 238, 英語
    速報，短報，研究ノート等（学術雑誌）

  • MEN1型膵内分泌腫瘍の局在診断
    金 東石, 村上 卓道, 中村 仁信
    1999年06月30日, 内分泌外科 = Endocrine surgery, 16(2) (2), 101 - 104, 日本語

  • 1417 膵頭十二指腸切除術後の周術期における肝動脈閉塞症例の検討
    辻 慶久, 中森 正二, 左近 賢人, 塩崎 憲, 大島 聡, 青木 太郎, 永野 浩昭, 堂野 恵三, 梅下 浩司, 村上 卓道, 中村 仁信, 門田 守人
    一般社団法人日本消化器外科学会, 1999年06月01日, 日本消化器外科学会雑誌, 32(6) (6), 1927 - 1927, 日本語

  • VS3-8 血流動態よりみた肝細胞癌に対する肝切除 : Xenon/CTによる腫瘍内血流からの分化度の判定と血管造影下CTによる切除範囲の決定
    永野 浩昭, 左近 賢人, 清水 潤三, 梅下 浩司, 岸本 慎一, 江口 英利, 宮本 敦史, 近藤 礎, 堂野 恵三, 中森 正二, 村上 卓道, 中村 仁信, 門田 守人
    一般社団法人日本消化器外科学会, 1999年06月01日, 日本消化器外科学会雑誌, 32(6) (6), 1430 - 1430, 日本語

  • 1140 肝細胞癌切除例における術前TAEの効果について
    江口 英利, 永野 浩昭, 左近 賢人, 梅下 浩司, 岸本 慎一, 宮本 敦史, 近藤 礎, 堂野 恵三, 中森 正二, 村上 卓道, 中村 仁信, 門田 守人
    一般社団法人日本消化器外科学会, 1999年06月01日, 日本消化器外科学会雑誌, 32(6) (6), 1854 - 1854, 日本語

  • 肝腫瘤性病変の診断 : CT
    村上 卓道, 中村 仁信
    1999年04月15日, Journal of medical ultrasonics = 超音波医学, 26(4) (4), 292 - 292, 日本語

  • Quantitative assessment of the regional hepatic tissue bloodflow (RHTBF) with xenon-enhanced CT
    J Shimizu, K Dono, M Sakon, M Takamura, T Murakami, H Nagano, S Nakamori, K Umeshita, H Nakamura, S Sase, H Oka, M Monden
    W B SAUNDERS CO-ELSEVIER INC, 1999年04月, GASTROENTEROLOGY, 116(4) (4), A1276 - A1276, 英語
    研究発表ペーパー・要旨（国際会議）

  • Percutaneous microwave hepatic tumor coagulation with segmental hepatic blood flow occlusion in seven patients
    T Murakami, T Shibata, T Ishida, T Niinobu, T Satoh, M Takamura, N Shibata, M Takami, H Nakamura
    OBJECTIVE, We assess the: usefulness of microwave hepatic tumor coagulation therapy with balloon occlusion of segmental hepatic blood flow for eight recurrent metastatic hepatic tumors in seven patients. CONCLUSION, Limited early experience with microwave hepatic tumor coagulation therapy and segmental hepatic blood Bow occlusion has been positive, suggesting that further clinical evaluation is warranted.
    AMER ROENTGEN RAY SOC, 1999年03月, AMERICAN JOURNAL OF ROENTGENOLOGY, 172(3) (3), 637 - 640, 英語

  • 肝特異性MRI用造影剤SH U 555 Aの肝腫瘍性疾患における有効性の検討 : 造影CTとの比較を中心に
    村上 卓道, 中村 仁信, 米虫 節夫, 廣橋 伸治, 尾野 亘, 打田 日出夫, 池田 耕士, 村田 貴史, 黒川 弘晶, 田中 敬正, 藤井 広一, 石田 修, 冨永 了, 中尾 宣夫, 吉川 明輝, 前田 ひろ子, 佐藤 守男
    1999年03月01日, 日本磁気共鳴医学会雑誌, 19(2) (2), 113 - 131, 日本語

  • Expandable metallic stent 挿入時の Vater 乳頭部の開存と胆道感染
    清水 潤三, 永野 浩昭, 左近 賢人, 堂野 恵三, 奥山 正樹, 武田 裕, 中森 正二, 梅下 浩司, 後藤 満一, 金 東石, 村上 卓道, 友田 要, 鳴海 善文, 中村 仁信, 門田 守人
    1999年02月25日, 胆道 = Journal of Japan Biliary Association, 13(1) (1), 32 - 38, 日本語

  • P-696 MRI造影剤super paramagnetic iron oxide (SPIO)による虚血再潅流障害時の肝網内系機能評価
    堂野 恵三, 清水 潤三, 左近 賢人, 高村 学, 村上 卓道, 加藤 直樹, 永野 浩昭, 中森 正二, 梅下 浩司, 中村 仁信, 門田 守人
    一般社団法人日本外科学会, 1999年02月10日, 日本外科学会雑誌, 100, 485 - 485, 日本語

  • P-417 Xe/CTを用いた肝組織血流量測定 : 門脈動脈分別測定の試み
    清水 潤三, 堂野 恵三, 左近 賢人, 高村 学, 村上 卓道, 宮本 敦史, 江口 英利, 奥山 正樹, 岸本 慎一, 永野 浩昭, 中森 正二, 梅下 浩司, 岡 博史, 中村 仁信, 門田 守人
    一般社団法人日本外科学会, 1999年02月10日, 日本外科学会雑誌, 100, 416 - 416, 日本語

  • 示I-239 PTPE前後での肝組織血流量の変化をXe/CTで評価し得た肝門部胆管癌の一例
    清水 潤三, 堂野 恵三, 左近 賢人, 高村 学, 村上 卓道, 近藤 礎, 柏崎 正樹, 宮本 敦史, 江口 英利, 奥山 正樹, 岸本 慎一, 合田 潔, 永野 浩昭, 中森 正二, 梅下 浩司, 岡 博史, 中村 仁信, 門田 守人
    一般社団法人日本消化器外科学会, 1999年02月01日, 日本消化器外科学会雑誌, 32(2) (2), 616 - 616, 日本語

  • Y Yoshida, Y Imai, T Murakami, M Nishikawa, M Kurokawa, T Yonezawa, K Tokunaga, Y Fukushima, K Wakasa, T Kim, H Nakamura, M Sakon, M Monden
    Two rare cases of small intrahepatic cholangiocarcinoma with marked hypervascularity are reported. Dynamic computed tomographic and magnetic resonance images of the two cases revealed strong enhancement of the whale tumor on the early phase and prolonged enhancement on the late and delayed phases. In both cases, the tumors turned out to be well-differentiated tubular cholangiocarcinoma that contained a large number of tumor cells and few interstitial fibrous tissues. These results suggest that some intrahepatic cholangiocarcinoma should be differentiated from other hypervascular hepatic tumors, especially hepatocelluar carcinoma, and that prolonged enhancement of the tumor on late and delayed phases of dynamic images could be of diagnostic value.
    SPRINGER VERLAG, 1999年01月, ABDOMINAL IMAGING, 24(1) (1), 66 - 68, 英語

  • Percutaneous microwave hepatic tumor coagulation therapy with stopping the hepatic blood flow: Experimental study
    M Takamura, T Murakami, T Shibata, T Ishida, T Niinobu, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 1998年11月, RADIOLOGY, 209P, 448 - 449, 英語
    研究発表ペーパー・要旨（国際会議）

  • 肝細胞癌における超常磁性酸化鉄SH U 555 Aの経時的造影効果の検討 : 臨床前期第II相試験
    谷本 伸弘, 平松 京一, 大友 邦, 村上 卓道, 中村 仁信
    1998年10月15日, 日本磁気共鳴医学会雑誌, 18(7) (7), 418 - 430, 日本語

  • Superparamagnetic iron oxide-enhanced MR imaging of hepatocellular carcinoma - Correlation with histological grading and tumor vascularity
    Y Imai, M Nishikawa, M Kurokawa, S Zushi, T Yonezawa, S Yoshida, K Tokunaga, M Murata, K Shibata, T Shimano, M Osawa, T Murakami, H Nakamura
    W B SAUNDERS CO, 1998年10月, HEPATOLOGY, 28(4) (4), 246A - 246A, 英語
    研究発表ペーパー・要旨（国際会議）

  • Effects of injection rates of contrast material on arterial phase hepatic CT
    T Kim, T Murakami, S Takahashi, K Tsuda, K Tomoda, Y Narumi, H Oi, H Nakamura
    OBJECTIVE. Our goal was to assess the effects of the IV injection rate of contrast material on arterial phase hepatic CT. SUBJECTS AND METHODS. One hundred patients were randomly divided into four groups of 25 with different injection rates of 90 ml of contrast material: 2, 3, 4, or 5 ml/sec. Single-level serial CT was performed at the level of the middle section of the main portal vein before injection and every 2 sec from 12 sec to 60 sec after injection of contrast material, The enhancement value was calculated as the difference in attenuation value between the unenhanced and contrast-enhanced images for the aorta and liver parenchyma. The duration of the arterial phase was defined as the interval beginning when the enhancement value for the aorta reached 100 H and ending when the value for the liver parenchyma reached 20 H. RESULTS. Faster injection rates increased the maximum enhancement of the aorta. Although faster injection rates decreased the time from injection to the beginning and the end of the arterial phase, faster injection rates did not decrease the duration of the arterial phase itself. CONCLUSION. A faster injection rate increases arterial enhancement of the liver, and the duration of the arterial phase remains the same as that occurring with a slower injection rate, We hypothesize that faster injection rates can provide better results using CT to reveal hypervascular liver tumors.
    AMER ROENTGEN RAY SOC, 1998年08月, AMERICAN JOURNAL OF ROENTGENOLOGY, 171(2) (2), 429 - 432, 英語

  • Evaluation of regional liver function by gadolinium-EOB-DTPA enhanced MR imaging.
    J Shimizu, K Dono, M Gotoh, Y Hasuike, T Kim, T Murakami, M Sakon, K Umeshita, H Nagano, S Nakamori, N Kato, T Miyazawa, H Nakamura, M Monden
    W B SAUNDERS CO, 1998年04月, GASTROENTEROLOGY, 114(4) (4), A1342 - A1342, 英語
    研究発表ペーパー・要旨（国際会議）

  • Takamichi Murakami, Tonsok Kim, Hironobu Nakamura
    Virus hepatitis and liver cirrhosis are found at high incidence in Asia, and they require not only biochemical examination of blood but also subsequent imaging, because they are often complicated by hepatocellular circinoma (HCC). It is, therefore, very important to know the specific appearance of hepatitis, liver cirrhosis, and HCC when we diagnose these diffuse liver diseases. Liver necrosis due to severe hepatitis is seen as high intensity on T2-weighted spin echo images. Regeneration is seen as low intensity on T2-weighted images. Morphologic and pathologic changes of cirrhotic liver are well demonstrated by MR imaging techniques. Fibrotic septum with inflammatory cell infiltration or rich pseudo bile duct show high intensity on T2-weighted images, and regenerating nodules shows low intensity. Gradient echo images show regenerating nodules with iron deposition as low-intensity nodules due to susceptibility artifact. MRI also has the potential to evaluate function of diffuse liver disease, cirrhosis, and hepatitis. MRI can visualize and diagnose HCC objectively. Dynamic MRI is very useful for diagnosing HCC. It is also applied for evaluation of effect after transcatheter arterial chemoembolization, because it shows enhancement only in the viable region at an arterial phase. MRI is less invasive and is thus an extremely important form of liver imaging.
    1998年03月, Journal of Magnetic Resonance Imaging, 8(2) (2), 346 - 358, 英語
    書評論文,書評,文献紹介等

  • Preoperative staging of endometrial carcinoma: Diagnostic effect of T2-weighted fast spin-echo MR imaging
    S Takahashi, T Murakami, Y Narumi, H Kurachi, K Tsuda, T Kim, T Enomoto, K Tomoda, A Miyake, Y Murata, H Nakamura
    PURPOSE: To evaluate the usefulness of T2-weighted fast spin-echo magnetic resonance (MR) imaging with a 512 x 256 matrix for assessment of the preoperative stage of endometrial carcinoma. MATERIALS AND METHODS: Twenty-eight women with histopathologically proved endometrial carcinoma underwent preoperative T2-weighted fast spin-echo, dynamic T1-weighted fast spin-echo, and postcontrast T1-weighted spin-echo MR imaging with a phased-array surface coil. The uterine long-axis planes in each sequence were reviewed at separate sessions by three radiologists blinded to the histopathologic data. RESULTS: For the diagnosis of myometrial invasion, no statistically significant differences were found among T2-weighted imaging, dynamic imaging, and postcontrast T1-weighted imaging. For the diagnosis of deep myometrial invasion, T2-weighted and dynamic images showed higher specificity than postcontrast T1-weighted images (T2-weighted, 89%; dynamic, 88%; and postcontrast T1-weighted, 80%). For cervical invasion, T2-weighted and dynamic images showed larger areas under receiver operating characteristic curves than did postcontrast T1-weighted images (T2-weighted, 0.78; dynamic, 0.71; and postcontrast T1-weighted, 0.67). CONCLUSION: T2-weighted imaging is useful for identifying the stage of endometrial carcinoma.
    RADIOLOGICAL SOC NORTH AMER, 1998年02月, RADIOLOGY, 206(2) (2), 539 - 547, 英語

  • Advanced hepatocellular carcinoma: therapeutic results in 110 patients and therapeutic strategy
    Y. Inoue, T. Ishida, T. Murakami, H. Nakamura
    The prognoses of 110 patients with advanced hepatocellular carcinoma (HCC) in stages III and IV were studied retrospectively. These patients were treated mainly by transarterial chemoembolization (TAE) or chemoinfusion using Lipiodol. Some of the patients underwent percutaneous ethanol injection therapy (PEIT) or tumor resection following TAE. Hepatic function, tumor stage, vascular involvement, type of tumor invasion, number of tumors and number of treatments affected the prognosis of the patients. The prognosis was better in the Child A group than in Child B and C. In the Child C group, the prognosis was markedly poor, and was least affected by any treatment. The prognoses in the patients with multiple nodular lesions, massive or diffuse lesions, were much poorer than those with a few nodular lesions. Tumor thrombosis in the central portal vein and distant metastasis greatly exacerbated the therapeutic results. Repeat therapy yielded a favorable therapeutic result when hepatic function was tolerable. Surgical intervention and PEIT were an effective therapy in a few patients. In advanced HCC, liver function and tumor extension should be fully evaluated, and it is important to determine the most effective therapeutic modalities to improve the survival of patients.
    1998年, Gan to kagaku ryoho. Cancer & chemotherapy, 25(12) (12), 1857 - 1864, 日本語
    書評論文,書評,文献紹介等

  • Imaging of renal mass lesions
    Y. Narumi, S. Takahashi, K. Tsuda, T. Kim, A. Okada, M. Hori, N. Miyahara, K. Tomoda, H. Oi, H. Nakamura, T. Murakami, C. Kuroda
    This review illustrates several imaging approaches for characterization and staging of renal masses with special attention to imaging findings that change the treatment options. CT is the method of choice for the evaluation of renal masses and MR imaging gives additional information to CT especially when the following findings are to be evaluated characterization of the content of the complicated cyst, demonstration of tumoral pseudocapsule, evaluation of venous thrombus and adjacent organ invasion for renal cell carcinoma. It should be stressed that integrated imaging approach is required for making decision in the treatment of renal masses.
    1998年, Japanese Journal of Clinical Radiology, 43(4) (4), 435 - 447, 日本語
    書評論文,書評,文献紹介等

  • Focal hepatic lesion detection: Comparison of four T2-weighted MR imaging pulse sequences
    M Kanematsu, H Hoshi, T Murakami, Y Inaba, M Hori, Y Nandate, R Yokoyama, H Nakamura
    PURPOSE: To evaluate T2-weighted magnetic resonance (MR) imaging with conventional spin-echo, breath-hold fast spin-echo, respiratory-triggered fast spin-echo, and breath-hold multishot spin-echo echo-planar sequences for detection of focal hepatic lesions. MATERIALS AND METHODS: T2-weighted MR images obtained with the four sequences in 56 patients with 107 solid and 124 nonsolid lesions were retrospectively analyzed. Image review was conducted on a liver segment-by-segment basis; a total of 408 liver segments were reviewed separately and independently for solid and nonsolid lesions by three radiologists. Diagnostic accuracy was evaluated with receiver operating characteristic analysis. RESULTS: Lesions-to-liver contrast-to-noise ratio was highest with multishot echo-planar images of both solid and nonsolid lesions. Diagnostic accuracy for solid lesions was statistically significantly better with conventional spin-echo images than with any other type of image (P<.0001). Diagnostic accuracy for nonsolid lesions was statistically significantly better with respiratory-triggered fast spin-echo images than with any other type of image (P<.0001). Image quality was best with breath-hold fast spin-echo images. CONCLUSION: Conventional spin-echo MR imaging should not be replaced with breath-hold fast spin-echo or multishot spin-echo echo-planar imaging, despite the shorter acquisition times that are possible with the latter two sequences.
    RADIOLOGICAL SOC NORTH AMER, 1998年01月, RADIOLOGY, 206(1) (1), 167 - 175, 英語

  • Detection of hepatocellular carcinoma in patients with cirrhosis: MR imaging versus angiographically assisted helical CT
    M Kanematsu, H Hoshi, T Murakami, Y Inaba, T Kim, T Yamada, M Kato, R Yokoyama, H Nakamura
    OBJECTIVE. The purpose of our study was to compare the combination of conventional spin-echo, phase-shift gradient-recalled echo (GRE), and triple-phasic dynamic GRE MR imaging with the combination of helical CT hepatic arteriography (CTA) and CT performed during arterial portography (CTAP) in the preoperative detection of hepatocellular carcinoma (HCC). MATERIALS AND METHODS, Thirty-seven patients with cirrhosis underwent MR imaging and angiographically assisted CT imaging. Paired T1- and T2-weighted spin-echo images, paired in-phase and out-of-phase GRE images, triple-phasic dynamic GRE images, the combined MR images, and the paired CTA and CTAP images were retrospectively and independently reviewed by three radiologists. Image review was done on a segment-by-segment basis, Of the 280 liver segments, 58 segments contained 79 HCCs that were 0.5-8.0 cm(mean, 2.0 cm) in diameter. The diagnostic value of each pair of images was rated by means of receiver operating characteristic curve analysis. RESULTS. The diagnostic accuracy of combined CTA and CTAP (mean area under the receiver operating characteristic curve [Az] = 0.94) was significantly better than that of spin-echo (Az = 0.86, p <.0001), phase-shift GRE (Az = 0.83, p <.0001), dynamic GRE (Az = 0.85, (p <.0001), and all combined (Az = 0.91, p <.001) MR imaging, The relative sensitivity of combined CTA and CTAP (89%) was also significantly (p <.0005) better than that of the combined MR imaging (75%). CONCLUSION, Angiographically assisted helical CT imaging was superior to MR imaging combined with conventional spin-echo, phase-shift GRE, and triple-phasic dynamic GRE techniques in the detection of HCC in patients with cirrhosis. The noninvasive dedicated combined MR imaging could not obviate invasive angiographically assisted CT imaging. Combined CTA and CTAP is recommended, especially in the preoperative examination of patients with HCC.
    AMER ROENTGEN RAY SOC, 1997年12月, AMERICAN JOURNAL OF ROENTGENOLOGY, 169(6) (6), 1507 - 1515, 英語

  • Signal intensity and morphologic behavior of the prostatic lesions on endorectal coil MR imaging: A prospective study
    M Cruz, K Tsuda, Y Narumi, T Murakami, S Takahashi, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 1997年11月, RADIOLOGY, 205, 46 - 46, 英語
    研究発表ペーパー・要旨（国際会議）

  • Small hepatic nodules in cirrhosis detected with ultrasonography: Correlation with CT, MR imaging, and histologic findings
    M Kanematsu, H Hoshi, T Yamada, T Murakami, T Kim, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 1997年11月, RADIOLOGY, 205, 1314 - 1314, 英語
    研究発表ペーパー・要旨（国際会議）

  • Effects of different rates and volumes of contrast material on enhancement of the pancreas with CT
    T Kim, T Murakami, S Takahashi, Y Narumi, H Oi, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 1997年11月, RADIOLOGY, 205, 625 - 625, 英語
    研究発表ペーパー・要旨（国際会議）

  • T2-weighted MR imaging of focal hepatic lesions: Comparison of conventional SE, breath-hold fast SE, respiratory-triggering fast SE, and breathhold multishot SE echo-planar imagings
    M Kanematsu, H Hoshi, T Murakami, Y Inaba, M Hori, Y Nandate
    RADIOLOGICAL SOC NORTH AMER, 1997年11月, RADIOLOGY, 205, 1195 - 1195, 英語
    研究発表ペーパー・要旨（国際会議）

  • Detection of hepatocellular carcinoma: Combined conventional spin-echo, phase-shift gradient-recalled-echo, and triple-phasic dynamic MR imagings versus angiographically-assisted helical CT
    M Kanematsu, H Hoshi, T Murakami, Y Inaba, T Kim, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 1997年11月, RADIOLOGY, 205, 14 - 14, 英語
    研究発表ペーパー・要旨（国際会議）

  • M Kanematsu, H Hoshi, T Yamada, Y Nandate, M Kato, R Yokoyama, T Murakami, H Nakamura
    Purpose: Overestimating the size of hepatic malignancy with helical CT during arterial portography (CTAP) can be a potential pitfall in determining liver resection area. We evaluated the prevalence and extent of overestimation of hepatic malignancy on CTAP in correlation with helical equilibrium phase CT (EPCT) and pathologic findings. Method: CTAP and EPCT in 47 histologically proven malignant hepatic tumors [33 hepatocellular carcinomas (HCCs) and 14 metastases] in 39 patients were retrospectively studied. Nineteen tumors were resected and pathologically evaluated. Results: The size overestimation ratios (CTAP/EPCT) ranged from 1.02 to 1.56 (mean +/- SD 1.24 +/- 0.16) in HCC and from 1.00 to 2.48 (1.34 +/- 0.42) in metastasis. In 19 surgical specimens, the overestimation ratios (CTAP/specimen) ranged from 1.05 to 1.45 (1.20 +/- 0.13) in HCC and from 1.10 to 1.38 (1.22 +/- 0.10) in metastasis. Histopathologically, flattening of parenchymal structures (100%), atrophy of hepatic cords (95%), sinusoidal congestions (95%), fibrosis and ductular proliferation (58%), and no tumor were seen in peritumoral parenchyma corresponding to perilesional perfusion defects with CTAP. Conclusion: CTAP frequently and significantly overestimates the size of malignant hepatic tumors. This phenomenon is attributable to either benign histopathological changes in the perilesional liver parenchyma caused by parenchymal compression or portal venous obstruction by malignant liver tumors or to a siphoning effect by hypervascular neoplasms.
    LIPPINCOTT-RAVEN PUBL, 1997年09月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 21(5) (5), 713 - 719, 英語

  • Aberrant right posterior biliary duct: Detection by intravenous cholangiography with helical CT
    T Murakami, T Kim, K Tomoda, Y Narumi, M Sakon, M Monden, H Nakamura
    LIPPINCOTT-RAVEN PUBL, 1997年09月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 21(5) (5), 733 - 734, 英語

  • 造影剤を用いたダイナミック撮像法 (97〜98年版ル-チンクリニカルMRI UP TO DATE) -- (先進MR医学の臨床応用)
    村上 卓道, 金 東石, 鳴海 善文
    産業開発機構, 1997年08月25日, 映像情報, 28(25) (25), 57 - 62, 日本語

  • T Kim, T Murakami, Y Hasuike, M Gotoh, N Kato, M Takahashi, T Miyazawa, Y Narumi, M Monden, H Nakamura
    To investigate the potential of gadolinium (Gd)-ethoxybenzyl (EOB)-diethylenetriamine-pentaacetic acid (DTPA) for evaluating liver function, chemically induced hepatitis animal models were studied, The rats in group 1 underwent intraperitoneal administration of 2.0 ml/kg and those in group 2 underwent intraperitoneal administration of .5 ml/kg of 50% (V/V) carbon tetrachloride (CCl4) solution. The rats in group 3 served as controls. For rats of each group, the signal intensity of the liver was measured on T1-weighted spin-echo NIR images acquired before and until 60 minutes after an intravenous injection of Gd-EOB-DTPA, The remaining rats in each group underwent indocyanine green test, serologic examination, or measurement of prothrombin time. Liver enhancement was compared with results of the other examinations, The degree of liver enhancement with Gd-EOB-DTPA was decreased and the washout of contrast was prolonged in the CCl4-administered groups, In this animal model, both hepatic dysfunction and liver enhancement were dose-dependent, MRI with Gb-EOB-DTPA has the potential to evaluate hepatic function.
    SOC MAGNETIC RESONANCE IMAGING, 1997年07月, JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 7(4) (4), 683 - 688, 英語

  • Helical CT during arterial portography and hepatic arteriography for detecting hypervascular hepatocellular carcinoma
    T Murakami, H Oi, M Hori, T Kim, S Takahashi, K Tomoda, Y Narumi, H Nakamura
    OBJECTIVE. We assessed whether helical CT hepatic arteriography (CTHA) improves detection of hypervascular hepatocellular carcinoma (HCC) when used in conjunction with helical CT obtained during arterial portography (CTAP). SUBJECTS AND METHODS, One hundred two patients with 254 hypervascular HCC nodules underwent both CTHA and CTAP. CTHA and CTAP were separately interpreted for detection of hypervascular HCC nodules by three observers who were unaware of tumor burden in the liver. Iodized oil CT performed 1 week and 1 month after transcatheter arterial chemoembolization with iodized oil was the gold standard. Sensitivity and positive predictive value for CTHA alone, CTAP alone, and CTAP and CTHA combined were calculated and compared using the McNemar test. RESULTS, We found no significant difference between the sensitivity of CTAP (85%) and CTHA (87%) for revealing hypervascular HCC nodules. The combination of CTAP and CTHA showed significantly higher sensitivity than either CTAP or CTHA alone for revealing HCC nodules smaller than 20 mm in diameter (p < .01). CONCLUSION, The combination of CTHA and CTAP is recommended to improve the detection sensitivity of small hypervascular HCC nodules.
    AMER ROENTGEN RAY SOC, 1997年07月, AMERICAN JOURNAL OF ROENTGENOLOGY, 169(1) (1), 131 - 135, 英語

  • 瀰慢性肝疾患のMRI : 今までの成果と今後の展望
    村上 卓道, 津田 恭, 金 東石, 友田 要, 鳴海 善文, 中村 仁信
    1997年06月01日, 日本磁気共鳴医学会雑誌, 17(4) (4), 199 - 207, 日本語

  • 416 MRI 造影剤 Gd-EOB-DTPA による部分肝機能評価(<特集>第50回日本消化器外科学会総会)
    清水 潤三, 堂野 恵三, 後藤 満一, 加藤 直樹, 高橋 昌哉, 宮澤 友明, 金 東石, 村上 卓道, 中村 仁信, 武田 裕, 三好 秀幸, 大里 浩樹, 梅下 浩司, 武田 力, 左近 賢人, 門田 守人
    一般社団法人日本消化器外科学会, 1997年06月01日, 日本消化器外科学会雑誌, 30(6) (6), 1458 - 1458, 日本語

  • Detection and characterization of hepatic tumors: Value of combined helical CT hepatic arteriography and CT during arterial portography
    M Kanematsu, H Hoshi, T Imaeda, T Murakami, Y Inaba, R Yokoyama, H Nakamura
    OBJECTIVE. The purpose of our study was to evaluate the diagnostic accuracy of combining helical CT hepatic arteriography (CTA) with helical CT during arterial portography (CTAP) for detecting and characterizing hepatic tumors. MATERIALS AND METHODS. From January 1994 to September 1995, combined helical CTA and CTAP were performed in 52 patients (38 men and 14 women, 37-83 years old [mean, 64.1 years old]) with suspected primary or metastatic hepatic tumors before they were evaluated for hepatic resection. Retrospectively, two radiologists reviewed the CTAP images alone and subsequently matched CTA and CTAP images. The radiologists recorded a confidence level on a five-point scale for their evaluation of visible perfusion abnormalities as true lesions, and diagnostic accuracy was assessed using receiver-operating-characteristic analysis. Using the data sets obtained at the interpretation sessions by the radiologists, we determined sensitivities for CTAP alone and for combined CTA and CTAP in 28 malignant hepatic tumors that were confirmed in 19 patients who underwent definitive surgery. RESULTS. CTA revealed one hepatocellular carcinoma in a patient with severe cirrhosis and six adenomatous hyperplasias in another cirrhotic patient that CTAP failed to reveal. In comparison with CTAP alone, the combination of CTA and CTAP allowed significantly more accurate detection of lesions (area under receiver-operating-characteristic curve: 0.889 for CTAP alone versus 0.954 for CTA and CTAP combined, p < .01). The combination of CTA and CTAP also significantly raised the accuracy for characterizing hepatic tumors. Sensitivities far malignant hepatic tumors revealed in the 19 patients who underwent surgery were identical: 93% (26 of 28 tumors) with CTAP alone and with CTA and CTAP combined. CONCLUSION. Although combining CTA and CTAP does not significantly increase sensitivity for detecting hepatic tumors, the combined techniques significantly raise specificity in detecting hepatic rumors and accuracy in characterizing hepatic tumors.
    AMER ROENTGEN RAY SOC, 1997年05月, AMERICAN JOURNAL OF ROENTGENOLOGY, 168(5) (5), 1193 - 1198, 英語

  • T2*-weighted dynamic MR imaging in renal artery or vein stenosis
    Y Tsushima, T Murakami, H Kuruma, T Kondo, S Kusano
    AMER ROENTGEN RAY SOC, 1997年04月, AMERICAN JOURNAL OF ROENTGENOLOGY, 168(4) (4), 1041 - 1043, 英語

  • 井上 正宏, 長谷川 利路, 草深 竹志, 佐々木 隆士, 福井 雄一, 福澤 正洋, 鎌田 振吉, 岡田 正, 村上 卓道
    特定非営利活動法人 日本小児外科学会, 1997年, 日本小児外科学会雑誌, 33(7) (7), 1171 - 1171, 日本語

  • Detectability of hepatocellular carcinoma: Comparison between CT with intraarterial injection and CT and MR imaging with intravenous injection of contrast material
    M Hori, T Murakami, H Oi, T Kim, S Takahashi, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 1996年11月, RADIOLOGY, 201, 1576 - 1576, 英語
    研究発表ペーパー・要旨（国際会議）

  • Size overestimation of hepatic malignancy at spiral CT during arterial portography: Correlation with findings at equilibrium-phase CT and pathologic examination
    M Kanematsu, H Hoshi, T Imaeda, S Mizuno, R Yokoyama, T Murakami
    RADIOLOGICAL SOC NORTH AMER, 1996年11月, RADIOLOGY, 201, 89 - 89, 英語
    研究発表ペーパー・要旨（国際会議）

  • Receiver operating characteristic analysis in preoperative staging of uterine endometrial carcinoma with MR imaging: Diagnostic impact of high-resolution T2-weighted images
    S Takahashi, T Murakami, K Tsuda, Y Narumi, T Kim, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 1996年11月, RADIOLOGY, 201, 594 - 594, 英語
    研究発表ペーパー・要旨（国際会議）

  • Preliminary experience with endorectal power Doppler imaging of the prostate and prostatic lesions: Comparison with color Doppler imaging
    Y Narumi, S Takahashi, M Murata, K Tsuda, T Murakami, H Nakamura
    RADIOLOGICAL SOC NORTH AMER, 1996年11月, RADIOLOGY, 201, 221 - 221, 英語
    研究発表ペーパー・要旨（国際会議）

  • CT angiography of living renal donors with spiral scanning: Comparison with 3D Fourier transform phase-contrast MR angiography
    K Tsuda, T Murakami, T Kim, S Takahashi, Y Narumi, S Takahara
    RADIOLOGICAL SOC NORTH AMER, 1996年11月, RADIOLOGY, 201, 1592 - 1592, 英語
    研究発表ペーパー・要旨（国際会議）

  • Unenhanced and triple-phase dynamic CT of the whole liver: Optimization of CT protocol for detecting hepatocellular carcinoma
    T Kim, T Murakami, S Takahashi, K Tsuda, K Tomoda, Y Narumi
    RADIOLOGICAL SOC NORTH AMER, 1996年11月, RADIOLOGY, 201, 1211 - 1211, 英語
    研究発表ペーパー・要旨（国際会議）

  • Staging of bladder cancer: Review of 160 cases
    Y Narumi, K Tsuda, S Takahashi, T Murakami, H Nakamura, N Hosomi
    RADIOLOGICAL SOC NORTH AMER, 1996年11月, RADIOLOGY, 201, 203 - 203, 英語
    研究発表ペーパー・要旨（国際会議）

  • Hepatocellular carcinoma: MR imaging with mangafodipir trisodium (Mn-DPDP)
    T Murakami, RL Baron, MS Peterson, JH Oliver, PL Davis, Confer, SR, MP Federle
    PURPOSE: To determine the efficacy of manganese (II) N,N'-dipyridoxylethylenediamino-N,N'-diacetate 5,5'bis(phosphate) (DPDP) at magnetic resonance (MR) imaging for evaluation of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: MR imaging at 1.5 T was performed in 20 patients with 65 HCC nodules. T1- and T2-weighted spin-echo and T1-weighted gradient-recalled-echo images were obtained before and after administration of 5 mu mol/kg Mn-DPDP. Readers individually evaluated the pre- and postcontrast images for detection of tumor nodules, with Subsequent consensus reading for interpretation discrepancies. Quantitative measurements of tumor-liver contrast-to-noise ratio (C/N) wore also performed. Enhancement characteristics were correlated with histologic tumor differentiation. RESULTS: Precontrast images depicted 50 lesions in 17 patients, and postcontrast images depicted 49 lesions in 20 patients. Combination of pre- and postcontrast images enabled detection of 53 lesions in 20 patients. Three lesions (three patients) were seen only on postcontrast images. Four lesions (three patients) were seen only on precontrast images. Reader evaluation of tumor conspicuity showed a significant preference for precontrast T2-weighted SE images (P < .01). Quantitative evaluation showed a significant increase in C/N on postcontrast T1-weighted images (P < .01). Well-differentiated lesions showed significantly greater enhancement than that of poorly differentiated lesions (P < .05). CONCLUSION: Mn-DPDP-enhanced MR imaging depicts HCC tumors not visualized with unenhanced studies. The degree of tumor enhancement correlates with histologic differentiation.
    RADIOLOGICAL SOC NORTH AMER, 1996年07月, RADIOLOGY, 200(1) (1), 69 - 77, 英語

  • 18 肝排泄型MRI造影剤 Gd-EOB-DTPA を用いた大量肝切除後の肝機能評価(<特集>第48回日本消化器外科学会総会)
    清水 潤三, 後藤 満一, 堂野 恵三, 蓮池 康徳, 金 東石, 村上 卓道, 大里 浩樹, 梅下 浩司, 左近 賢人, 中村 仁信, 門田 守人
    一般社団法人日本消化器外科学会, 1996年06月01日, 日本消化器外科学会雑誌, 29(6) (6), 1297 - 1297, 日本語

  • 高速シネフェーズコントラストMR imagingによる呼吸停止下門脈血流測定
    原田 貢士, 田中 寿, 柏木 伸夫, 中村 仁信, 稲葉 文隆, 村上 卓道, 櫻井 康介, 津田 恭, 金 東石, Nakamura Hironobu, Harada Koshi, Kashiwagi Nobuo, Tanaka Hisashi, Kim Tonsoku, Tsuda Kyo, Sakurai Kosuke, Murakami Takamichi, Inaba Fumitaka, カシワギ ノブオ, ナカムラ ヒロノブ, ハラダ コウシ, タナカ ヒサシ, キム トンソク, ツダ キョウ, サクライ コウスケ, ムラカミ タカミチ, イナバ フミタカ
    日本医学放射線学会, 1996年03月25日, 日本医学放射線学会雑誌, 56(4) (4), 217 - 219, 日本語

  • Cirrhosis of the liver: MR imaging with mangafodipir trisodium (Mn-DPDP)
    T Murakami, RL Baron, MP Federle, MS Peterson, JH Oliver, PL Davis, Confer, SR
    PURPOSE: To evaluate the usefulness of manganese (II) N, N'-dipyridoxylethylenediamine-N, N'-diacetate 5,5'-bis(phosphate) (Mn-DPDP) in magnetic resonance (MR) imaging of cirrhotic livers. MATERIALS AND METHODS: Fifty-eight patients (mean age, 58.8 years), 29 with and 29 without cirrhosis, underwent MR imaging before and after intravenous administration of 5 mu mol/kg Mn-DPDP. Enhancement effects were assessed quantitatively and qualitatively. Histologic confirmation was obtained in 51 patients. RESULTS: Liver parenchyma in both patient groups enhanced significantly on T1-weighted spin-echo and gradient-recalled-echo (GRE) images (P < .01). However, cirrhotic livers enhanced significantly less than noncirrhotic livers on T1-weighted GRE images (P <.05). Fourteen cirrhotic livers had heterogeneous enhancement of parenchyma; enhancement was more prominent on GRE images. Decreased enhancement was seen in patients with confluent fibrosis (n = 5), diffuse fibrosis (n = 6), and siderotic regenerating nodules (n = 4). Increased enhancement was seen in patients with benign regenerating nodules (n = 4). CONCLUSION: Mn-DPDP is useful in patients with cirrhosis.
    RADIOLOGICAL SOC NORTH AMER, 1996年02月, RADIOLOGY, 198(2) (2), 567 - 572, 英語

  • Liver necrosis and regeneration after fulminant hepatitis: Pathologic correlation with CT and MR findings
    T Murakami, RL Baron, MS Peterson
    PURPOSE: To characterize computed tomographic (CT) and magnetic resonance (MR) findings of liver necrosis and regeneration after fulminant hepatitis. MATERIALS AND METHODS: Three patients with fulminant hepatitis underwent CT before orthotopic liver transplantation; one also underwent MR imaging. These findings were retrospectively reviewed and compared with gross and histologic findings obtained after transplantation. RESULTS: Regions of liver necrosis demonstrated low attenuation on CT scans before contrast material was administered and enhanced to attenuation equal to or greater than that of liver regeneration on postcontrast CT images. Conversely, nodular liver regeneration demonstrated hyperattenuation on precontrast and hypoattenuatian on postcontrast CT images, which simulated neoplastic lesions. The necrotic liver parenchyma was seen as high and low intensity on T2- and T1-weighted MR images, respectively, whereas areas of regeneration appeared as hypo- and hyperintense. CONCLUSION: Characteristic patterns of liver regeneration after fulminant hepatitis may be seen at CT and MR imaging. Recognition of this regeneration process may avoid an incorrect diagnosis of malignancy.
    RADIOLOGICAL SOC NORTH AMER, 1996年01月, RADIOLOGY, 198(1) (1), 239 - 242, 英語

  • DELAYED RETENTION OF GADOLINIUM WITHIN LIVER NEOPLASMS DETECTED WITH CONTRAST-ENHANCED MR-IMAGING
    MS PETERSON, T MURAKAMI, RL BARON
    RADIOLOGICAL SOC NORTH AMER, 1995年11月, RADIOLOGY, 197, 176 - 176, 英語
    研究発表ペーパー・要旨（国際会議）

  • DYNAMIC GADOLINIUM-ENHANCED MR-IMAGING OF HEPATIC MALIGNANCIES - UTILITY OF ARTERIAL AND PORTAL VENOUS PHASE IMAGES
    MS PETERSON, RL BARON, T MURAKAMI
    RADIOLOGICAL SOC NORTH AMER, 1995年11月, RADIOLOGY, 197, 176 - 176, 英語
    研究発表ペーパー・要旨（国際会議）

  • MR-IMAGING OF CERVICAL-CARCINOMA - COMPARISON BETWEEN T2-WEIGHTED, DYNAMIC, AND POSTCONTRAST T1-WEIGHTED IMAGES WITH HISTOPATHOLOGIC CORRELATION
    K TSUDA, T MURAKAMI, H KURACHI, H OGAWA, A MIYAKE, H NAKAMURA
    RADIOLOGICAL SOC NORTH AMER, 1995年11月, RADIOLOGY, 197, 475 - 475, 英語
    研究発表ペーパー・要旨（国際会議）

  • EFFICACY OF MN-DPDP-ENHANCED MR-IMAGING IN THE EVALUATION OF HEPATOCELLULAR-CARCINOMA
    T MURAKAMI, RL BARON, MP FEDERLE, MS PETERSON, JH OLIVER, PL DAVIS
    RADIOLOGICAL SOC NORTH AMER, 1995年11月, RADIOLOGY, 197, 414 - 415, 英語
    研究発表ペーパー・要旨（国際会議）

  • Hypervascularな小肝細胞癌のSpiral CTによる全肝Dynamic CT
    金 東石, 大井 博道, 村上 卓道, 松下 正樹, 岸本 陽督, 高島 庄太夫, 中村 仁信, 小塚 隆弘
    日本医学放射線学会, 1995年04月25日, 日本醫學放射線學會雜誌, 55(5) (5), 296 - 299, 日本語

  • A CASE OF NONMETASTATIC TROPHOBLASTIC DISEASE FOLLOWED BY MAGNETIC-RESONANCE-IMAGING
    K FUKAMI, H KURACHI, T MURAKAMI, K TSUDA, T MAEDA, H NAKAMURA, A MIYAKE
    The consecutive findings of the magnetic resonance (MR) imaging in a patient with nonmetastatic trophoblastic disease are reported. On MR image, there are noted two kinds of MR findings which suggest the existence of trophoblastic disease; one was a typical hypervascular mass of heterogeneous signal intensity within myometrium, and the other was the increase in myometrial and parametrial flow void. The former finding appeared only for a short period while the disease was highly active. The latter finding well paralleled the serum human chorionic gonadotropin (hCG) level, and the remarkable flow void, indicating dilatated blood vessels, disappeared with the complete remission of the disease. These findings suggest that MR imaging may be useful for diagnosing and following gestational trophoblastic disease.
    MUNKSGAARD INT PUBL LTD, 1995年03月, ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 74(3) (3), 233 - 235, 英語
    記事・総説・解説・論説等（学術雑誌）

  • CONTRAST-ENHANCED MR-IMAGING OF INTRAHEPATIC CHOLANGIOCARCINOMA - PATHOLOGICAL CORRELATION STUDY
    T MURAKAMI, H NAKAMURA, K TSUDA, T ISHIDA, K TOMODA, S HORI, M MONDEN, T KANAI, K WAKASA, M SAKURAI, T KOZUKA
    The authors describe the enhanced magnetic resonance (MR) imaging appearance of intrahepatic cholangiocarcinoma. The MR images of eight patients with intrahepatic cholangiocarcinoma who underwent MR examination within 3 weeks before partial hepatectomy were retrospectively studied. The MR images, including a dynamic study, were compared directly with pathologic and histologic findings. The peripheral region of the medullary subtype of cholangiocarcinoma, with many tumor cells, showed greater enhancement relative to liver parenchyma in the early phase. The peripheral region of the scirrhous subtype, with fewer tumor cells showed less enhancement in the early phase. In one patient, the thin rim of the medullary tumor showed less enhancement in the late phase, and this rim corresponded to the peripheral region of the medullary tumor with many tumor cells. The central region of tumors with a large amount of fibrous tissue showed prolonged enhancement in the late and delayed phases. The thin rim of liver parenchyma around the tumor showed less enhancement in the early phase and greater enhancement in the late phase; this rim corresponded to congestive liver parenchyma with dilated sinusoids. Intrahepatic cholangiocarcinoma shows various enhancement patterns, which depend on both the histologic subtype and the degree and distribution of fibrosis within the tumor.
    SOC MAGNETIC RESONANCE IMAGING, 1995年03月, JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 5(2) (2), 165 - 170, 英語

  • 肝腫瘍性病変の鑑別における3DFT-FISP法を用いたDynamic-MR imagingの有用性
    石田 毅, 村上 卓道, 堀 信一, 友田 要, 三谷 尚, 小塚 隆弘, 門田 守人, 若狭 研一, 橋本 達, 中村 仁信, 津田 恭, 中西 克之, Hashimoto Toru, Mitani Takashi, Tomoda Kaname, Hori Shinichi, Nakanishi katsuyuki, Tsuda Kyo, Nakamura Hironobu, Murakami Takamichi, Ishida Takeshi, Kozuka Takahiro, Monden Morito, Wakasa Kenichi, トモダ カナメ, ワカサ ケンイチ, モンデン モリト, コヅカ タカヒロ, ハシモト トオル, ミタニ タカシ, ホリ シンイチ, ナカニシ カツユキ, ツダ キョウ, ナカムラ ヒロノブ, ムラカミ タカミチ, イシダ タケシ
    日本医学放射線学会, 1994年02月25日, 日本医学放射線学会雑誌, 54(2) (2), 101 - 108, 日本語

  • Appearance of low intensity band seen around the abdominal organs on gradient echo image
    T. Murakami, M. Matushita, H. Igarashi, H. Oi, T. Kim, H. Yamazaki, H. Nakamura, T. Kozuka
    To clarify the mechanism of appearance of low intensity band seen around the abdominal organ, we performed phantom study. The resected intestine, which filled with water and fixed in the salad oil, was obtained by spoiled GRASS MR imaging with variable TEs and fixed TR. On in phase image, low intensity band was seen in low frequency side of frequency encoding direction of surface of the intestine, and high intensity band in high frequency side. On out of phase image, low intensity band is seen all around the intestine. Our phantom study verified that the appearance of low intensity band on out of phase gradient echo image is due to both the misregistration and signal void caused by chemical shift artifact.
    1993年07月25日, Nippon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 53(7) (7), 862 - 864

  • 経皮経胸郭的肝穿刺術の実験的検討
    津田 恭, 中村 仁信, 石田 毅, 友田 要, 堀 信一, 橋本 達, 村上 卓道, 三谷 尚, 中西 克之, 小塚 隆弘, Nakamura Hironobu, Ishida Takeshi, Tsuda Kyo, Nakanishi Katsuyuki, Mitani Takashi, Murakami Takamichi, Hashimoto Toru, Hori Shinichi, Tomoda Kaname, Kozuka Takahiro, イシダ タケシ, コズカ タカヒロ, ナカムラ ヒロノブ, ツダ キョウ, ナカニシ カツユキ, ミタニ タカシ, ムラカミ タカミチ, ハシモト トオル, ホリ シンイチ, トモダ カナメ
    日本医学放射線学会, 1993年04月25日, 日本医学放射線学会雑誌, 53(4) (4), 475 - 477, 日本語

  • RESPONSE TO TRANSCATHETER OILY CHEMOEMBOLIZATION IN HEPATOCELLULAR-CARCINOMA 3-CM OR LESS - A STUDY IN 50 PATIENTS WHO UNDERWENT SURGERY
    H NAKAMURA, T LIU, S HORI, H MITANI, T MURAKAMI, T KOZUKA, C KURODA, M MONDEN, M SAKURAI, K WAKASA
    The response of 50 patients who underwent hepatectomy for hepatocellular carcinoma measuring 3 cm or less (at the time of surgery) to transcatheter oily chemoembolization was evaluated. The response was assessed in 5 categories, A: complete necrosis (100 %), B: necrosis of at least 95 %, C: at least 80 %, but less than 95 %, D: at least 50 % but less than 80 %, and E: less than 50 % of the tumor cells. Response A was observed in 19 patients (38 %), B in 7 (14 %), C in 9 (18 %), D in 7 (14 %), and E in 8 (16 %). These results were classified with respect to the histological degree of tumor differentiation, the WHO histological classification, the microscopic patterns of tumor growth, and macroscopic classification The response was evaluated in relation to the histological grade of tumor differentiation and the WHO histological classification in all categories of response except response A, and there was no significant difference between the categories. The response was obviously better with the expansive type than with the replacing type. Single nodular type lesions were more responsive than the single nodular type lesions with extranodular growth and the contiguous multinodular type. Pretreatment estimation of the microscopic patterns of tumor growth and macroscopic classification appears to be valuable in predicting prognosis.
    H G E UPDATE MEDICAL PUBL LTD., 1993年02月, HEPATO-GASTROENTEROLOGY, 40(1) (1), 6 - 9, 英語

  • TREATMENT OF HEPATOCELLULAR-CARCINOMA BY CHEMOEMBOLIZATION - EVALUATION WITH 3DFT MR IMAGING
    T MURAKAMI, H NAKAMURA, K TSUDA, K NAKANISHI, S HORI, K TOMODA, T MITANI, T KOZUKA, M MONDEN, K WAKASA
    OBJECTIVE. We evaluated the usefulness of an MR imaging technique that used dynamic three-dimensional Fourier transformation (3DFT) fast imaging with steady-state precession (FISP) with gadopentetate dimeglumine for detecting viable regions of hepatocellular carcinoma following transcatheter arterial chemoembolization with iodized oil (Lipiodol). Images obtained with the 3DFT FISP technique were directly correlated with hepatectomy specimens. SUBJECTS AND METHODS. Dynamic 3DFT FISP MR imaging was performed after transcatheter arterial chemoembolization and before partial hepatectomy in 10 patients with 10 tumors of hepatocellular carcinoma. Imaging parameters were 20/8/30-degrees (TR/TE/flip angle) with a slab thickness of 21-75 mm and seven or 15 partitions. 3DFT FISP images were obtained at the slice level where a tumor had been detected on T1- and/or T2-weighted spin-echo MR images before, just after (early phase), and 1 and 2 min after (late phase) IV administration of gadopentetate dimeglumine (0.1 mmol/kg). We directly compared the dynamic MR images of the 10 patients with the gross and microscopic findings. RESULTS. On early-phase images, tumors of hepatocellular carcinoma showed no enhancement in three patients and partial intense enhancement in seven. Viable regions of the tumor showed intense enhancement relative to the surrounding liver parenchyma in the early phase, whereas necrotic regions showed no enhancement in either the early or the late phase. Both viable and necrotic regions had lower signal intensities than did the surrounding liver parenchyma in the late phase. By using dynamic 3DFT MR imaging, we were able to accurately assess the effect of transcatheter arterial chemoembolization with iodized oil in nine of the 10 patients. However, in one patient in whom microscopically viable cells were seen in the capsule of the carcinoma, viable regions could not be detected with our technique. CONCLUSION. Dynamic 3DFT MR imaging was useful in differentiating viable regions of hepatocellular carcinoma from necrotic regions following transcatheter arterial chemoembolization with iodized oil.
    AMER ROENTGEN RAY SOC, 1993年02月, AMERICAN JOURNAL OF ROENTGENOLOGY, 160(2) (2), 295 - 299, 英語

  • 新しい血管塞栓物質の研究-高吸水性ポリマー・リピオドール懸濁液-
    堀 信一, 前島 宗也, 三谷 尚, 村上 卓道, 中西 克之, 小塚 隆弘, 井上 悦男, 黒田 知純, 中村 仁信, 友田 要, 橋本 達, 石田 毅, Nakamura Hironobu, Nakanishi Katsumi, Murakami Takamichi, Mitani Takashi, Ishida Tsuyoshi, Hashimoto Toru, Tomoda Kaname, Maeshima Souya, Hori Shinichi, Kozuka Takahiro, Inoue Etsuo, Kuroda Chikazumi, ムラカミ タカミチ, クロダ チカズミ, イノウエ エツオ, コズカ タカヒロ, ナカムラ ヒロノブ, ナカニシ カツミ, ミタニ タカシ, イシダ ツヨシ, ハシモト トオル, トモダ カナメ, マエシマ ソウヤ, ホリ シンイチ
    日本医学放射線学会, 1993年01月25日, 日本医学放射線学会雑誌, 53(1) (1), 50 - 56, 日本語

  • 膝蓋内側滑膜ヒダのMR imaging
    友田 要, 中西 克之, 堀 信一, 井上 雅裕, 村上 卓道, 津田 恭, 三谷 尚, 橋本 達, 前島 宗也, 中村 仁信, 小塚 隆弘, Hori Shinichi, Tomoda Kaname, Maeshima Souya, Hashimoto Toru, Mitani Takashi, Tsuda Kyou, Murakami Takamichi, Inoue Masahiro, Nakanishi Katsuyuki, Nakamura Hironobu, Kozuka Takahiro, マエシマ ソウヤ, コズカ タカヒロ, ナカムラ ヒロノブ, ホリ シンイチ, トモダ カナメ, ハシモト トオル, ミタニ タカシ, ツダ キョウ, ムラカミ タカミチ, イノウエ マサヒロ, ナカニシ カツユキ
    日本医学放射線学会, 1992年12月25日, 日本医学放射線学会雑誌, 52(12) (12), 1647 - 1652, 日本語

  • 画像でみる生体情報-1-肝のMRI
    中村 仁信, 村上 卓道, 小塚 隆弘
    中山書店, 1992年12月, モレキュラ-メディシン, 30(1) (1), p92 - 95, 日本語

  • TREATMENT OF ESSENTIAL GROSS HEMATURIA - EXPERIMENTAL AND CLINICAL-STUDY OF RENAL ARTERIAL INFUSION OF MIXTURE OF AUTOLOGOUS BLOOD AND IOPAMIDOL
    S HORI, T MITANI, K TOMODA, H NAKAMURA, T HASHIMOTO, T MURAKAMI
    RADIOLOGICAL SOC NORTH AMER, 1992年11月, RADIOLOGY, 185, 259 - 260, 英語
    研究発表ペーパー・要旨（国際会議）

  • 3次元フーリエ変換FISP法による肝細胞癌のDynamic MR imaging
    三谷 尚, 門田 守人, 橋本 達, 村上 卓道, 中村 仁信, 堀 信一, 友田 要, 中西 克之, 津田 恭, 若狭 研一, Monden Morito, Hashimoto Toru, Mitani Takashi, Tsuda Kyo, Nakanishi Katsuyuki, Tomoda Kaname, Hori Shinichi, Nakamura Hironobu, Murakami Takamichi, Wakasa Kenichi, ハシモト トオル, ワカサ ケンイチ, モンデン モリト, ミタニ タカシ, ツダ キョウ, ナカニシ カツユキ, トモダ カナメ, ホリ シンイチ, ナカムラ ヒロノブ, ムラカミ タカミチ
    日本医学放射線学会, 1992年07月25日, 日本医学放射線学会雑誌, 52(7) (7), 1030 - 1032, 日本語

  • CT AND MRI OF SIDEROTIC REGENERATING NODULES IN HEPATIC CIRRHOSIS
    T MURAKAMI, H NAKAMURA, S HORI, K NAKANISHI, T MITANI, K TSUDA, T KOZUKA, K WAKASA, M MONDEN
    The demonstration by CT of siderotic regenerating liver nodules in cirrhosis was evaluated and compared with that of MR imaging retrospectively in 27 patients with histologically diagnosed hepatic cirrhosis. Only in one of the two patients with marked iron deposits in regenerating nodules did CT demonstrate multiple high density nodules. In the other patient with marked iron deposits and in seven of the nine patients with moderate iron deposits, the liver parenchyma on CT was demonstrated as heterogeneous and of slightly high density without focal nodules. In 8 patients with mild to moderate iron deposits and in the 10 with no iron deposits, the liver parenchyma was homogeneous on CT. Multiple low intensity nodules in the liver were seen on fast low-angle shot (FLASH) MR images in all 17 patients with iron deposits in regenerating nodules. No low intensity nodules were seen on FLASH MR images in the 10 patients with no iron deposits. If there are iron deposits above a certain level, siderotic regenerating nodules may appear as nodules of high density on CT or as heterogeneous regions of high density liver parenchyma. Magnetic resonance is more sensitive than CT in demonstrating siderotic regenerating nodules.
    LIPPINCOTT-RAVEN PUBL, 1992年07月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 16(4) (4), 578 - 582, 英語

  • Inversion recovery snapshot FLASH 法によるTI時間の違いを利用した肝細胞癌と肝血管腫の鑑別の検討
    三谷 尚, 前島 宗也, 橋本 達, 津田 恭, 村上 卓道, 中西 克之, 中村 仁信, 堀 信一, 友田 要, 小塚 隆弘, Maeshima Soya, Hashimoto Toru, Mitani Takashi, Tomoda Kaname, Hori Shinichi, Nakamura Hironobu, Nakanishi Katsuyuki, Murakami Takamichi, Tsuda Kyo, Kozuka Takahiro, ハシモト トオル, コズカ タカヒロ, マエシマ ソヤ, ミタニ タカシ, トモダ カナメ, ホリ シンイチ, ナカムラ ヒロノブ, ナカニシ カツユキ, ムラカミ タカミチ, ツダ キョウ
    日本医学放射線学会, 1992年06月25日, 日本医学放射線学会雑誌, 52(6) (6), 838 - 840, 日本語

  • 肝硬変再生結節のMRI-病理像,MR像および血液学的所見の対比-
    若狭 研一, 小塚 隆弘, 桜井 幹己, 門田 守人, 村上 卓道, 黒田 知純, 中村 仁信, 堀 信一, 丸川 太朗, Monden Morito, Wakasa Kenichi, Sakurai Masami, Kozuka Takahiro, Marukawa Taro, Hori Shinichi, Nakamura Hironobu, Kuroda Chikazumi, Murakami Takamichi, サクライ マサミ, モンデン モリト, ワカサ ケンイチ, コズカ タカヒロ, マルカワ タロウ, ホリ シンイチ, ナカムラ ヒロノブ, クロダ チカズミ, ムラカミ タカミチ
    日本医学放射線学会, 1992年03月25日, 日本医学放射線学会雑誌, 52(3) (3), 279 - 285, 日本語

  • DIFFERENTIATION BETWEEN HEPATOMA AND HEMANGIOMA WITH INVERSION-RECOVERY SNAPSHOT FLASH MRI AND GD-DTPA
    T MURAKAMI, T MITANI, H NAKAMURA, S HORI, T MARUKAWA, K NAKANISHI, M NISHIKAWA, C KURODA, T KOZUKA
    Thirty-eight patients with focal liver tumors (20 hepatomas, 18 hemangiomas) were studied by dynamic sequential inversion recovery (IR) snapshot fast low angle shot (FLASH) MR imaging with Gd-DTPA. Immediately after 0.05 mmol/kg Gd-DTPA was administered intravenously for 2-3 s followed by flushing with normal saline for 4-5 s, 10 images were obtained in the first 20 s (time zero is the end of flush, early phase). Then, one image every 30 s from 1 to 3 min (late phase) and images at 5 min and 7 min (delayed phase) were obtained serially. Hepatomas showed total enhancement in 18 of 20 patients in the early phase, and isointense or low intensity enhancement with respect to the surrounding liver parenchyma in 18 patients in the late to delayed phases. Hemangiomas showed peripheral enhancement in 14 patients in the early phase, but did not show total enhancement (except for two hemangiomas < 3 cm in size) in the early phase, and showed high intensity enhancement in 15 patients in the late phase. Ninety percent of hepatomas and 82% of hemangiomas showed their characteristic enhancement patterns in the early to delayed phases. We conclude that dynamic sequential IR snapshot FLASH MR images enhanced with Gd-DTPA can facilitate differentiation between hepatomas and hemangiomas.
    LIPPINCOTT-RAVEN PUBL, 1992年03月, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 16(2) (2), 198 - 205, 英語

  • 膝蓋骨亜脱臼症候群のMRI
    櫻井 康介, 金 尚元, 藤田 典彦, 小塚 隆弘, 中西 克之, 井上 雅裕, 原田 貢士, 村上 卓道, Nakanishi Katsuyuki, Kozuka Takahiro, Sakurai Kousuke, Fujita Norihiko, Kim Shogen, Murakami Takamichi, Harada Koushi, Inoue Masahiro, コズカ タカヒロ, サクライ コウスケ, フジタ ノリヒコ, キム ショウゲン, ムラカミ タカミチ, ハラダ コウシ, イノウエ マサヒロ, ナカニシ カツユキ
    日本医学放射線学会, 1991年04月25日, 日本医学放射線学会雑誌, 51(4) (4), 387 - 393, 日本語

  • 門脈腫瘍塞栓合併肝細胞癌のダイナミックMRI
    原田 貢士, 中村 仁信, 堀 信一, 三谷 尚, 村上 卓道, 西川 正則, 前島 宗也, 中西 克之, 丸川 太朗, 小塚 隆弘, Nakamura Hironobu, Hori Shinichi, Harada Koushi, Marukawa Taro, Nakanishi Katsuyuki, Maeshima Souya, Nishikawa Masanori, Murakami Takamichi, Mitani Takashi, Kozuka Takahiro, ホリ シンイチ, コヅカ タカヒロ, ナカムラ ヒロノブ, ハラダ コウセイ, マルカワ タロウ, ナカニシ カツユキ, マエシマ ソウヤ, ニシザワ マサノリ, ムラカミ タカミチ, ミタニ タカシ
    日本医学放射線学会, 1991年02月25日, 日本医学放射線学会雑誌, 51(2) (2), 188 - 190, 日本語

  • REGENERATING NODULES IN HEPATIC CIRRHOSIS - MR FINDINGS WITH PATHOLOGICAL CORRELATION
    T MURAKAMI, C KURODA, T MARUKAWA, K HARADA, K WAKASA, M SAKURAI, M MONDEN, A KASAHARA, S KAWATA, T KOZUKA
    AMER ROENTGEN RAY SOC, 1990年12月, AMERICAN JOURNAL OF ROENTGENOLOGY, 155(6) (6), 1227 - 1231, 英語

  • 肝腫瘍性病変のDynamic-MRI-Inversion recovery snap shot FLASH法による検討-
    黒田 知純, 原田 貢士, 徳永 仰, 小塚 隆弘, 村上 卓道, 三谷 尚, 西川 正則, 中西 克之, 丸川 太朗, Kozuka Takahiro, Kuroda Chikazumi, Tokunaga Koh, Harada Koushi, Marukawa Taro, Nakanishi Katsuyuki, Nishikawa Masanori, Mitani Takashi, Murakami Takamichi, トクナガ コウ, コヅカ タカヒロ, クロダ チカズミ, ハラダ コウシ, マルカワ タロウ, ナカニシ カツユキ, ニシカワ マサノリ, ミタニ タカシ, ムラカミ タカミチ
    日本医学放射線学会, 1990年11月25日, 日本医学放射線学会雑誌, 50(11) (11), 1451 - 1453, 日本語

  • サンプリング周波数帯域のMR画像に与える影響
    原田 貢士, 金 尚元, 小塚 隆弘, 櫻井 康介, 藤田 典彦, 村上 卓道, Kim Shongwon, Sakurai Kousuke, Fujita Norihiko, Kozuka Takahiro, Harada Koushi, Murakami Takamichi, フジタ ノリヒコ, サクライ コウスケ, ムラカミ タカミチ, コヅカ タカヒロ, ハラダ コウシ, キム ションウォン
    日本医学放射線学会, 1990年08月25日, 日本医学放射線学会雑誌, 50(8) (8), 910 - 917, 日本語

  • 三方向diffusion encodingを用いた拡散係数イメージングの研究
    村上 卓道, 中西 克之, 小塚 隆弘, 原田 貢士, 藤田 典彦, 櫻井 康介, 金 尚元, Sakurai Kousuke, Harada Koushi, Kozuka Takahiro, Murakami Takamichi, Nakanishi Katsuyuki, Kin Syogen, Fujita Norihiko, ハラダ コウシ, コズカ タカヒロ, ムラカミ タカミチ, ナカニシ カツユキ, キン ショウゲン, フジタ ノリヒコ, サクライ コウスケ
    日本医学放射線学会, 1990年02月25日, 日本医学放射線学会雑誌, 50(2) (2), 198 - 200, 日本語

  • 腰椎MRIにおけるMultiple Spin Echo法とLow Flip Angle Gradient Echo法の対比
    藤田 典彦, 村上 卓道, 原田 貢士, 小塚 隆弘, Fujita Norihiko, Murakami Takamichi, Kozuka Takahiro, Harada Koushi, ハラダ コウシ, コズカ タカヒロ, ムラカミ タカミチ, フジタ ノリヒコ
    日本医学放射線学会, 1989年07月25日, 日本医学放射線学会雑誌, 49(7) (7), 850 - 856, 日本語

  • CTにおける新しい肝造影剤Lipiodol-Iopamidol Emulsionによる試み
    小塚 隆弘, 橋本 達, 鳴海 善文, 堀 信一, 村上 卓道, 西川 正則, 藤田 典彦, Nishikawa Masanori, Hori Shinichi, Narumi Yoshifumi, Kozuka Takahiro, Hashimoto Touru, Fujita Norihiko, Murakami Takamichi, ホリ シンイチ, ナルミ ヨシフミ, コズカ タカヒロ, ハシモト トオル, フジタ ノリヒコ, ムラカミ タカミチ, ニシカワ マサノリ
    日本医学放射線学会, 1988年12月25日, 日本医学放射線学会雑誌, 48(12) (12), 1503 - 1510, 日本語

■ 書籍等出版物
  • 消化器内科 第33号( vol.4)
    祖父江慶太郎, 村上卓道
    共著, Ⅱ CT：2-3. CTを用いたびまん性肝疾患の診断と定量評価の可能性：特集 肝疾患における画像診断の進歩－腹部超音波, CT, MRI－, 医学出版, 2022年09月, ISBN: 9784287920336

  • 日本インターベンショナルラジオロジー学会雑誌 36巻3号
    上嶋 英介, 祖父江 慶太郎, 松代 啓吾, 佐々木 康二, 元津 倫幸, 岡田 卓也, 山口 雅人, 杉本 幸司, 村上 卓道
    共著, TACEにおける腫瘍微小環境の変化と分子標的薬・免疫治療併用の意義 P.244-253, J-STAGE, 2022年08月

  • 臨床画像38巻6号
    曽菲比, 野上宗伸, 村上卓道
    共著, 特集 放射線診断医を悩ませる全身イメージング 18F–FDG PET/MRIを用いた全身画像診断−PETとDWIBSの比較−, メジカルビュー社（ISSN 0911-1069）, 2022年06月

  • Innervision Vol.37 No.4
    矢部慎二, 祖父江慶太郎, 堀 雅敏, 村上卓道
    共著, 特集：Precious Medicine時代の Abdominal Imaging 2022 腹部画像診断の最新動向とすぐそこの未来に備えて【後編：CT，XA/DR，核医学】：V CT：腹部領域における技術の到達点および臨床の最前線：1．CTによる腹部画像診断の最新動向と未来への展望：1）腹部領域におけるdual energy CTを中心としたCT技術の有用性と可能性 37(4):2-5, Innervision Vol.37 No.4, 2022年04月, ISBN: 9784910561127

  • 消化器画像診断の勘ドコロNEO
    大西裕満, 村上卓道
    共著, Ⅱ各論編：肝・膵：海綿状血管腫 p98-99, メジカルビュー社, 2021年07月, 日本語, ISBN: 9784758316187

  • 消化器画像診断の勘ドコロNEO
    大西裕満, 村上卓道
    共著, Ⅱ各論編：肝・膵：肝細胞腺癌 p96-97, メジカルビュー社, 2021年07月, 日本語, ISBN: 9784758316187

  • 消化器画像診断の勘ドコロNEO
    大西裕満, 村上卓道
    共著, Ⅱ各論編：肝・膵：肝内胆管癌 p92-93, メジカルビュー社, 2021年07月, 日本語, ISBN: 9784758316187

  • 消化器画像診断の勘ドコロNEO
    大西裕満, 村上卓道
    共著, Ⅱ各論編：肝・膵：転移性肝癌 p90-91, メジカルビュー社, 2021年07月, 日本語, ISBN: 9784758316187

  • 消化器画像診断の勘ドコロNEO
    大西裕満, 村上卓道
    共著, Ⅱ各論編：肝・膵：肝細胞癌 p86-89, メジカルビュー社, 2021年07月, 日本語, ISBN: 9784758316187

  • 消化器画像診断の勘ドコロNEO
    大西裕満, 村上卓道
    共著, Ⅱ各論編：総説：肝・脾CT撮像の考え方とおさえどころ p52-58, メジカルビュー社, 2021年07月, 日本語, ISBN: 9784758316187

  • 肝臓専門医テキスト改訂第3版
    祖父江慶太郎, 村上卓道
    共著, Ⅱ章 Ａ 検査 7 画像診断 p120-150, 南江堂, 2020年11月, 1299-1310, 日本語, ISBN: 9784524227716
    学術書

  • 肝癌診療マニュアル第4版
    鶴﨑正勝, 吉満研吾, 村上卓道
    共著, 第7章,肝癌の治療効果判定 B,TACEの治療効果判定 p232-234, 医学書院, 2020年04月, 日本語, ISBN: 9784260040815

  • 肝癌診療マニュアル第4版
    田中利洋, 宮山士朗, 村上卓道
    共著, 第6章,肝癌の治療 C,肝癌治療の実際 3,肝動脈化学塞栓法(TACE) d,Beads TACEとConventional TACE をどう使い分けるか p144-146, 医学書院, 2020年04月, 日本語, ISBN: 9784260040815

  • 肝癌診療マニュアル第4版
    宮山士朗, 村上卓道
    共著, 第6章,肝癌の治療 C,肝癌治療の実際 3,肝動脈化学塞栓法(TACE) a,Conventional TACE p134-138, 医学書院, 2020年04月, 日本語, ISBN: 9784260040815

  • 肝癌診療マニュアル第4版
    今井康陽, 工藤正俊, 泉 並木, 村上卓道, 熊田 卓
    共著, 第5章,肝癌の診断 C,肝癌診断のアルゴリズム 2,乏血性肝細胞性結節（異型結節、早期肝癌）の自然経過と治療対応 p84-87, 医学書院, 2020年04月, 日本語, ISBN: 9784260040815

  • 肝癌診療マニュアル第4版
    建石良介, 工藤正俊, 泉 並木, 村上卓道
    共著, 第5章,肝癌の診断 C,肝癌診断のアルゴリズム 1,肝細胞癌の診断アルゴリズム p82-84, 医学書院, 2020年04月, 日本語, ISBN: 9784260040815

  • 肝癌診療マニュアル第4版
    斎藤 聡, 今井康陽, 村上卓道, 工藤正俊
    共著, 第5章,肝癌の診断 B,画像診断 3,どのようなときにGd-EOB-DTPA p58-61, 医学書院, 2020年04月, 日本語, ISBN: 9784260040815

  • 肝癌診療マニュアル第4版
    吉満研吾, 村上卓道
    共著, 第5章,肝癌の診断 B,画像診断 2,CTとMRIの使い分け p56-58, 医学書院, 2020年04月, 日本語, ISBN: 9784260040815

  • 肝癌診療マニュアル第4版
    祖父江慶太郎, 吉満研吾, 村上卓道
    共著, 第5章,肝癌の診断 B,画像診断 1,総論 p53-56, 医学書院, 2020年04月, 53-56, 日本語
    学術書

  • 第3版MRIデータブック
    村上卓道
    分担執筆, FUS, in phase/out of phase, chemical shift artifact p44,116,142, メジカルビュー社, 2019年11月

  • 新臨床静脈学
    岡田卓也, 京谷勉輔, 宮崎亜樹, 村上卓道
    共著, 総論Ⅲ章:検査法(検体, 画像) 3,画像診断 C,MRI p83-88, メジカルビュー社, 2019年10月, 83-88
    学術書

  • Springer Nature Switzerland AG
    Sofue K, Tsurusaki M, Murakami T
    共著, Multislice CT, Fourth Edition p447-489, Springer, 2019年

  • ここまできた肝臓病診療
    鶴﨑正勝, 祖父江慶太郎, 村上卓道
    共著, 画像診断 血管造影, 中山書店, 2017年10月

  • プリンシプル消化器疾患の臨床3 ここまできた肝臓病診療
    甲斐田勇人, 石井一成, 村上卓道
    共著, 画像診断 核医学検査, 中山書店, 2017年10月

  • 放射線治療学改訂6版
    村上卓道
    分担執筆, 24展望：新しい画像診断と放射線治療, 南山堂, 2017年07月, ISBN: 9784525270964

  • 画像診断ガイドライン 2016年版
    村上 卓道
    共編者(共編著者), 金原出版, 2016年09月, ISBN: 4307071050

  • Key所見からよむ肝胆膵脾の画像診断 肝臓編
    村上卓道, 村上 卓道, 吉満 研吾, 兼松 雅之, 赤羽 正章, 鶴﨑 正勝
    監修, メジカルビュー社, 2016年04月, 日本語, ISBN: 4758315914

  • Key所見からよむ肝胆膵脾の画像診断 胆膵脾編
    村上卓道, 村上 卓道, 吉満 研吾, 兼松 雅之, 赤羽 正章, 鶴﨑 正勝
    監修, メジカルビュー社, 2016年03月, ISBN: 4758315922

  • MRI応用自在, MRガイド下集束超音波療法（MR-GUIDED FUS)
    村上 卓道
    共著, メジカルビュー社, 2013年10月

  • 肝胆膵脾のCT・MRI診断
    村上, 卓道, 岡田, 真広
    共著, 金芳堂, 2013年10月, 日本語, ISBN: 9784765315814

  • 科学的根拠に基づく肝癌診療ガイドライン 2013年版
    村上 卓道
    共編者(共編著者), 金原出版, 2013年10月, ISBN: 4307203186

  • 画像診断ガイドライン 2013年版
    村上 卓道
    共編者(共編著者), 金原出版, 2013年07月, ISBN: 4307070933

  • EOB-MRI/Sonazoid超音波による肝癌の診断と治療, EOB-MRIの早期肝癌と異型結節（DN)の識別診断能：EOB-MRIによる早期肝癌の診断能：生検標本との対比
    今井 康陽, 村上 卓道
    共著, 医学書院, 2013年06月

  • EOB-MRI/Sonazoid超音波による肝癌の診断と治療, EOB-MRIの基本的知識：EOB-MRIによる肝機能評価
    岡田 真広, 村上 卓道
    共著, 医学書院, 2013年06月

  • EOB-MRI/Sonazoid超音波による肝癌の診断と治療, EOB-MRIの基本的知識：最適な撮像法
    村上 卓道, 岡田 真広
    共著, 医学書院, 2013年06月

  • 画像診断
    柏木 伸夫, 村上 卓道
    共著, 克誠堂, 2013年05月

  • 診療ガイドラインに沿った肝癌治療の要点と盲点, 血管侵襲の診断：血管造影を施行しない場合
    柳生 行伸, 村上 卓道
    共著, 文光堂, 2013年03月

  • 消化器画像診断・IVR
    楢林 勇, 杉村 和朗, 廣田 省三, 村上 卓道
    金芳堂, 2012年11月, 日本語, ISBN: 9784765315463

  • 放射線医学 消化器画像診断・IVR
    楢林 勇, 杉村 和朗, 廣田 省三, 村上 卓道
    共編者(共編著者), 金芳堂, 2012年11月, ISBN: 4765315460

  • 肝癌診療マニュアル 第2版, 肝癌の診断 画像診断 どのようなときにGd-EOB-MRIを行うか.
    工藤 正俊, 井上 達夫, 村上 卓道
    共著, 医学書院, 東京, 2010年07月

  • medicina medicina, CT・MRIアトラスupdate 正常解剖と読影のポイント；子宮
    安藤理奈, 藤谷哲也, 村上 卓道
    共著, 医学書院, 2009年11月

  • 腹部画像診断アトラス, Prostatic cystic epithelial stromal tumorとその再発巣の悪性転化の一例
    荒木哲朗, 桑原雅知, 村上 卓道
    共著, 2008年

  • 肝臓病の最新治療, Multidetector-row CT
    村上 卓道, 大西裕満
    共著, 2007年04月

  • Medico Medico, 腹部MRI画像診断の最近の話題
    熊野 正士, 村上 卓道, 今岡 いずみ, 下野 太郎, 金 東石
    共著, 千代田開発株式会社, 2007年04月

  • Annual Review 2007 消化器, 肝臓：肝癌の画像診断
    岡田 真広, 村上 卓道
    共著, 中外医薬社, 2007年01月

  • 臨床画像, 上腹部消化器系のCT・MRIお勧め撮像法
    村上 卓道
    単著, メジカルビュー社, 2006年09月

  • Knack & Pitfalls 肝臓外科の要点と盲点 第２版, 手術を前提とした総合画像診断 幕内 雅敏，高山 忠利 編
    堀 雅敏, 村上 卓道
    共著, 文光堂, 2006年04月

  • 腹部画像診断の勘ドコロ, 画像診断：第２章肝・脾：CT撮像の考え方と診断学レビュー：高橋雅士監修, 兼松雅之編
    村上 卓道, 大西裕満
    共著, メジカルビュー社, 2006年03月

  • 肝臓病の最新治療, Multidetector-row CT
    村上 卓道
    共著, 先端医療技術研究所, 2006年

  • 肝臓外科の要点と盲点, 肝腫瘍診断のKnack & Pitfalls, 手術を前提とした総合画像診断
    堀 雅敏, 村上 卓道
    共著, 文光堂, 2006年

  • MRIデータブック, FUS, in phase/out of phase, chemical shift artifact
    村上 卓道
    共著, メディカルビュー社, 2006年

  • 肝転移のすべて, MRI
    金 東石, 村上 卓道
    共著, 長井書店, 2005年

  • Medical Radiology, Diagnostic Imaging, Diagnostic Imaging, Multidetector-Row CT Angiography
    村上 卓道
    共著, Springer-Verlag Berlin-Heidelberg-New York, 2004年

  • Managing patient dose in computed tomography, Managing patient dose in computed tomography
    村上 卓道
    共著, The International Commission on Radiological Protection, 2004年

  • 肝疾患 治療 コンセンサス2004, 肝細胞癌 局所療法 Radiological Intervention (肝動脈塞栓療法)
    村上 卓道
    共著, アークメディア, 2004年

  • 改訂版応用自在, MRガイド下集束超音波療法
    村上 卓道
    共著, メディカルビュー社, 2004年

  • 肝疾患Review 2004, 肝癌の診断, 治療の進歩：MDCTによる肝細胞癌診断の進歩
    村上 卓道
    共著, 日本メディカルセンター, 2004年

  • CTにおける患者線量の管理, ICRP Publication 87
    村上 卓道
    共著, 日本アイソトープ協会, 2004年

  • 肝の最新MRI
    村上 卓道
    共著, 金原出版, 2004年

  • The Asian-Oceanian Textbook of Radiology, Diseases of the liver and biliary three.
    村上 卓道
    共著, Singapore, TTG Asia Media Pte Ltd, 2003年

  • 画像診断, 最近の肝の画像診断
    村上 卓道
    共著, 秀潤社, 2003年

  • Murakami T, Kim T, Takahashi S, Nakamura H. Diseases of the liver and biliary three. In: Peh WCG and Hiramatsu Y, ed. The Asian-Oceanian Textbook of Radiology.
    Singapore, TTG Asia Media Pte Ltd,, 2003年

  • 腹部・骨盤部造影検査のキーワード132
    土屋, 一洋, 村上, 卓道
    共著, メジカルビュー社, 2002年12月, 日本語, ISBN: 4758308063

  • IVRの技法
    村上 卓道, 中村仁信, 中村 仁信, 村上 卓道, 沢田 敏, 谷川 昇
    共編者(共編著者), 南江堂, 2002年11月, ISBN: 4524222952

  • Scanographie volumique multicoupe: Principles, applications et perspectives, Etude dynamique du carcinome hepato-cellulaire. Angioscanner des vaisseaux pancreatiques
    村上 卓道
    共著, Masson, Paris, 2002年

  • 婦人科検査マニュアル：データの読み方から評価まで, 画像診断：MRI
    津田 恭, 村上 卓道
    共著, 医学書院, 2002年

  • 胸腹部・骨盤部CT・MRI診断のキーワード160
    土屋, 一洋, 村上, 卓道
    共著, メジカルビュー社, 2002年01月, 日本語, ISBN: 4895539474

  • Murakami T. Etude dynamique du carcinome hepato-cellulaire. Angioscanner des vaisseaux pancreatiques. In: Blum A, ed. Scanographie volumique multicoupe: Principles, applications et perspectives.
    Masson, Paris., 2002年

  • Multidetector Helical CTのすべて, Multidetector CTによる膵疾患の診断
    金 東石, 村上 卓道
    共著, 金原出版, 2001年

  • IVR器材と手技・ポイント, 経皮的胆嚢ドレナージ
    岡田篤哉, 村上 卓道
    共著, メジカルビュー社, 2001年

  • 全身性疾患，フィルムリーディング, 肝臓のびまん性病変
    村上 卓道
    共著, 医学書院, 2001年

  • Upper放射線医学，画像診断学, 肝、胆、膵、脾
    井上 豊, 村上 卓道
    共著, 南山堂, 2001年

  • Intervertional Radiology ; Lipiodol Chemoembolization
    II chakak, 1999年

  • Liver Cancer : Arterial embolization
    Churchill Livingstone, 1997年

  • 日本インターベンショナルラジオロジー学会雑誌36(3)

  • 18 F-FDG PET/MRIを用いた全身画像診断 -PETとDWIBSの比較-

■ 講演・口頭発表等
  • Usefulness of the Contrast Enhancement Boost technique combined with virtual monoenergetic images in dual-energy CT for the evaluation of hypervascular hepatocellular carcinoma.
    Yabe S, Sofue K, Hori M, Maebayashi T, Nishigaki M, Tsujita Y, Yamaguchi T, Ueshima E, Murakami T
    European Congress of Radiology 2023, 2023年03月, 英語

  • Advanced CT techniques in the evaluation of hepatocellular carcinoma: Roles of ultra-high-resolution CT, dual-energy CT, contrast enhancement boost technique, and radiomics. Radiological Society of North America.
    Hori M, Sofue K, Yabe S, Nishigaki M, Akino N, Yamaguchi T, Tsujita Y, Ueshima E, Negi N, Kusaka A, Murakami T
    108th Scientific Assembly and Annual Meeting., 2022年11月

  • Radiomic Features of Hepatocellular Carcinoma at Ultra-High-Resolution CT with a 1024 Matrix: Dependencies on Matrix Size and Reconstruction Algorithm. Radiological Society of North America.
    Hori M, Sofue K, Akino N, Nishigaki M, Yabe S, Yamaguchi T, Tsujita Y, Ueshima E, Murakami T
    108th Scientific Assembly and Annual Meeting., 2022年11月, 英語

  • 巨大静脈瘤を伴う腎動静脈瘻に対し経動脈的塞栓および静脈血紮にて腎機能温存下に治療しえた1例.
    八幡 宥徳, 上嶋英介, 幸田陽次郎, 宮原俊介, 松代啓吾, 佐々木康二, 元津倫幸, 岡田卓也, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    第28回兵庫県IVR懇話会, 2022年11月

  • Novel deep learning-based noise reduction for zero echo time MRI on PET/MRI: Utility of half-minute lung imaging for oncology patients.
    Nogami M, Tachibana M, Inukai J, Zeng F, Kurimoto T, Kubo K, Murakami T
    The 35th Annual Congress of the European Association of Nuclear Medicine., 2022年10月, 英語

  • Zero-TE MR-based Attenuation Correction with Deep Learning Approach: Impact of bone components on Attenuation Correction for chest FDG PET/MRI.
    Tachibana M, Nogami M, Matsuo H, Nishio M, Inukai J, Zeng F, Kurimoto T, Kubo K, Murakami T
    The 35th Annual Congress of the European Association of Nuclear Medicine., 2022年10月, 英語

  • Respiratory-gated FDG PET/CT versus PET/MRI with zero-echo time: Assessment of the capability to detect and differentiate lunglesions and the precision of fused images.
    Inukai J, Nogami M, Zeng F, Tachibana M, Sakamoto S, Takenaka D, Kubo K, Kurimoto T, Murakami T
    The 35th Annual Congress of the European Association of Nuclear Medicine., 2022年10月, 英語

  • New CT techniques in abdominal radiology. Application of novel imaging techniques in abdominal imaging. Special Focus Sessions 3, Abdomen.
    Murakami T
    AOCR2022 ＆ KCR2022., 2022年09月, 英語
    [招待有り]
    口頭発表（招待・特別）

  • Time- synchronized FDG PET/MRI with Bayesian penalized likelihood reconstruction algorithm.
    Tachibana M, Nogami M, Inukai J, Zeng F, Kurimoto T, Kubo K, Murakami T
    The 13th Congress of the World Federation of Nuclear Medicine and Biology., 2022年09月, 英語

  • Assessment of region-based detection and differentiation capability of rapid whole-body FDG PET/MRI scans using a combination of Bayesian penalized likelihood PET reconstruction and abbreviated whole-body MRI in oncology patients.
    Inukai J, Nogami M, Tachibana M, Zeng F, Kubo K, Murakami T
    The 13th Congress of the World Federation of Nuclear Medicine and Biology., 2022年09月, 英語

  • Added Value of Contrast Enhancement Boost Images in Routine Multiphasic Contrast-Enhanced CT in Diagnosis of Small Hypervascular Hepatocellular Carcinoma.
    Yabe S, Sofue K, Hori M, Maebayashi T, Nishigaki M, Tsujita Y, Yamaguchi T, Ueshima E, Murakami T
    European Congress of Radiology 2022., 2022年07月, 英語
    口頭発表（一般）

  • 心臓病変を認めたErdheim Chester病の1例
    杉山直生, 橋村宏美, 河野 淳, 野上宗伸, 村上卓道, 高橋宗史, 藤川良一, 伊澤 有, 鳥羽敬義, 原 重雄
    第331回日本医学放射線学会関西地方会, 2022年06月, 日本語
    口頭発表（一般）

  • Embolization Induced Tumor-Associated Macrophage Polarization in Tumor Immune Microenvironment can be Reprogrammed by Lenvatinib in a Rat Hepatoma Model
    Ueshima E, Sofue K, Takaki H, Hirata Y, Kodama H, Hamada M, Matsushiro K, Sasaki K, Gentsu T, Okada T, Yamaguchi M, Yamakado K, Sugimoto K, Murakami T
    Society of Interventional Radiology 2022, 2022年06月, 英語

  • Utility of abbreviated MRI combined with Bayesian penalized likelihood PET reconstruction during rapid whole-body FDG PET/MRI in oncology patients: Assessment of the detection and differentiation capabilities in different regions of the body.
    Inukai J, Nogami M, Tachibana M, Zeng F, Kubo K, Murakami T
    SNMMI 2022 Annual Meeting., 2022年06月, 英語

  • Diagnostic utility of time-synchronized FDG PET/MRI with the Bayesian penalized likelihood reconstruction algorithm for T-classification of uterine endometrial cancer.
    Tachibana M, Nogami M, Inukai J, Zeng F, Kubo K, Kurimoto T, Murakami T
    SNMMI 2022 Annual Meeting., 2022年06月

  • Preemptive aortic side branch embolization before EVAR with ENDURANT:A prospective multicenter study
    Gentsu T, Yamaguchi M, Sasaki K, Kawasaki R, Horinouchi H, Sakamoto N, Uotani K, Miyamoto N, Fukuda T, Taniguchi T, Mori T, Ueshima E, OkadaT, Sgugimoto K, Murakami T
    Asia Pacific Society Cardiovascular and interventional Radiology. 2022, 2022年06月, 英語

  • Preemptive aortic side branch embolization before EVAR with ENDURANT:A prospective multicenter study.
    Gentsu T, Yamaguchi M, Sasaki K, Kawasaki R, Horinouchi H, Sakamoto N, Uotani K, Miyamoto N, Fukuda T, Taniguchi T, Mori T, Ueshima E, OkadaT, Sgugimoto K, Murakami T
    Asia Pacific Society Cardiovascular and interventional Radiology., 2022年06月, 英語
    口頭発表（一般）

  • 画像診断のCutting edge－線維化・脂肪化・腫瘍性状診断：指定発表 肝画像診断のCutting edge
    村上卓道
    第58回日本肝臓学会総会 パネルディスカッション5, 2022年06月, 日本語
    シンポジウム・ワークショップパネル（指名）

  • パネルディスカッション5：画像診断のCutting edge－線維化・脂肪化・腫瘍性状診断：【指定発表】肝画像診断のCutting edge
    村上卓道
    第58回日本肝臓学会総会, 2022年06月, 日本語, 国内会議
    [招待有り]
    シンポジウム・ワークショップパネル（指名）

  • 多血性肝細胞癌診断におけるCE boost技術の有用性の検討
    矢部慎二, 祖父江慶太郎, 堀雅敏, 辻田有志, 山口尊, 上嶋英介, 上野嘉子, 村上卓道
    第58回日本肝癌研究会 パネルディスカッション1, 2022年05月, 日本語

  • パネルディスカッション1：多血性肝細胞癌診断におけるCE boost技術の有用性の検討
    矢部慎二, 祖父江慶太郎, 堀雅敏, 辻田有志, 山口尊, 上嶋英介, 上野嘉子, 村上卓道
    第58回日本肝癌研究会, 2022年05月, 日本語
    シンポジウム・ワークショップパネル（公募）

  • Lenvatinib投与による塞栓術後の腫瘍関連マクロファージ極性化の制御効果：ラット肝癌モデルでの検討
    上嶋英介, 祖父江慶太郎, 高木治行, 平田 豊, 児玉大志, 岡田卓也, 山口雅人, 山門亨一郎, 杉本幸司, 村上卓道
    第81回日本医学放射線学会総会, 2022年04月, ジャワ語
    ポスター発表

  • 多血性小肝細胞癌診断におけるCEboost技術の有用性の検討
    矢部慎二, 祖父江慶太郎, 堀 雅敏, 辻田有志, 山口 尊, 上嶋英介, 村上卓道
    第81回日本医学放射線学会総会, 2022年04月, 日本語
    シンポジウム・ワークショップパネル（公募）

  • Added Value of Contrast Enhancement Boost Images in Routine Multiphasic Contrast-Enhanced CT in Diagnosis of Small Hypervascular Hepatocellular Carcinoma.
    Yabe S, Sofue K, Hori M, Maebayashi T, Nishigaki M, Tsujita Y, Yamaguchi T, Ueshima E, Murakami T
    European Congress of Radiology 2022., 2022年03月, 英語

  • 特別講演「肝臓MRIの最近の話題」
    村上 卓道
    第39回岐阜放射線医学セミナー, 2022年03月, 日本語
    [招待有り]
    口頭発表（招待・特別）

  • 特別講演Ⅱ「画像診断法の進歩とAI役割」
    村上卓道
    第22回桜山イメージングセミナー, 2022年03月, 名古屋, 国内会議
    口頭発表（招待・特別）

  • 特別講演「TACEにおける肝癌微小環境の変化と全身化学療法併用の意義」
    村上卓道
    生涯教育講座 県北肝・代謝疾患研究会（Web開催）, 2022年02月, 国内会議
    口頭発表（招待・特別）

  • IVR医の職業被曝による左右非対称顔面皮膚変化についての調査研究
    米虫 敦, 谷川 昇, 奥田逸子, 白川崇子, ウッドハムス玲子, 煎本正博, 米虫隆貴, 葛西健一郎, 村上卓道
    第70回関西IVR研究会（Web開催）, 2022年02月, 国内会議
    口頭発表（一般）

  • 超高精細CTで同定し得た肝外側副血行路からTACEを行った肝細胞癌の1例
    松代啓吾, 上嶋英介, Mostafa Hamada, 佐々木康二, 元津倫幸, 岡田卓也, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    第70回関西IVR研究会（Web開催）, 2022年02月, 国内会議
    口頭発表（一般）

  • 直腸静脈瘤に対して内視鏡装置バルーンによる血流コントロールを併用したPTOの1例
    谷 龍一郎, 富田 優, 宮本直和, 林 宏樹, 吉江智郎, 川端直樹, 梅野晃弘, 上月瞭平, 難波富美子, 濱中章洋, 足立秀治, 杉本幸司, 村上卓道
    第70回関西IVR研究会（Web開催）, 2022年02月, 国内会議
    口頭発表（一般）

  • 指導者講習会「日本専門医機構と放射線科領域の専門医制度について」
    村上卓道
    第330回日本医学放射線学会関西地方会（Web開催）, 2022年02月

  • Session16: Diagnosis of HCC: Imaging Evaluation of HCC in the Systemic Treatment Era.
    Murakami T
    APASL Oncology 2021(Hybrid), 2021年12月, 英語, 国際会議

  • 大学病院における遺伝的アルゴリズムを用いた当直予定表作成システムの開発
    松尾秀俊, 松永卓明, 佐々木康二, 岡田卓也, 西尾瑞穂, 河野 淳, 村上卓道
    第41回医療情報学連合学会, 2021年11月
    ポスター発表

  • 慢性血栓塞栓性肺高血圧症患者における低侵襲・高精度な肺動脈平均圧の予測モデル作成
    吉井隆浩, 松尾秀俊, 高橋真依, 西尾瑞穂, 河野 淳, 谷口 悠, 平田健一, 村上 卓道
    第41回医療情報学連合学会, 2021年11月
    ポスター発表

  • 深層学習を用いたZTE MRIによる胸部PET/MRIの吸収補正に関する定量的検証
    野上宗伸, 松尾秀俊, 西尾瑞穂, 曽 菲比, 犬養純子, 立花美保, 栗本貴子, 久保和広, 村上卓道
    第61回日本核医学会学術総会, 2021年11月
    口頭発表（一般）

  • 肺転移の診断能と融合画像精度におけるZTE併用FDG PET/MRIとPET/CTとの比較
    犬養純子, 野上宗伸, 曽 菲比, 立花美保, 久保和広, 栗本貴子, 村上卓道
    第61回日本核医学会学術総会, 2021年11月
    口頭発表（一般）

  • Use of AI for liver lesion characterization: Radiomics, artificial intelligence, and deep learning: current and future roles in liver imaging, including gadoxetic acid MRI.
    Murakami T
    The 10th Global Liver Forum(online), 2021年10月, 英語

  • SessionⅣ 胸部：左房内膜肉腫の一例
    田川純麗, 橋村宏美, 河野 淳, 村上卓道, 伊澤 有, 鳥羽敬義, 清田尚臣, 井上 武, 小松正人
    第329回日本医学放射線学会関西地方会（ハイブリッド開催）, 2021年10月
    口頭発表（一般）

  • Advanced CT and MRI for Hepatocellular Carcinoma.
    Murakami T, Hori M, Sofue K
    JSH International Liver Conference 2021, 2021年10月, 英語, 福岡
    [招待有り]
    シンポジウム・ワークショップパネル（指名）

  • 新型コロナウイルス肺炎の画像診断と人口知能の応用：基礎から学ぶ新型コロナウイルス
    村上卓道
    第81回日本医学放射線学会「レントゲンの日記念」市民公開講座, 2021年10月, 日本語
    [招待有り]
    公開講演，セミナー，チュートリアル，講習，講義等

  • 肝臓MRI－最新の話題－
    村上卓道
    肝臓MRIセミナー, 2021年10月, 日本語
    公開講演，セミナー，チュートリアル，講習，講義等

  • 50歳代女性に生じ術前診断が困難であった卵巣卵黄嚢腫瘍の一例
    田川純麗, 上野嘉子, 浦瀬靖代, 今岡いずみ, 祖父江慶太郎, 神田知紀, 野上宗伸, 鷲尾佳一, 山崎友維, 寺井義人, 小松正人, 村上卓道
    第22回JSAWI（Web開催）, 2021年09月, 日本語
    ポスター発表

  • 慢性血栓塞栓性肺高血圧症患者における、重回帰分析を使用した肺動脈平均圧推定についての検討
    髙橋真依, 松尾秀俊, 西尾瑞穂, 松永卓明, 河野 淳, 村上卓道, 谷口 悠, 平田健一
    第57回日本医学放射線学会秋季臨床大会（Web開催）, 2021年09月, 日本語
    口頭発表（一般）

  • 薬物療法時代における画像評価のポイント
    村上卓道
    肝細胞癌Meet The Expert in 播磨, 2021年09月, 日本語
    公開講演，セミナー，チュートリアル，講習，講義等

  • 上腹部CE-boostにおいてboost回数が造影効果および画質に及ぼす影響
    矢部慎二, 祖父江慶太郎, 堀 雅敏, 辻田有志, 山口 尊, 上嶋英介, 上野嘉子, 村上卓道
    最先端CT研究会2021（ハイブリッド開催）, 2021年07月, 日本語
    口頭発表（一般）

  • EVAR後の内腸骨動脈瘤をUp-and-over techniqueを用いてExcluder IBEで治療した1例
    佐々木康二, 岡田卓也, 山口雅人, 松代啓吾, 元津倫幸, 上嶋英介, 杉本幸司, 村上卓道
    第69回関西IVR研究会（Web開催）, 2021年07月

  • 多血性肝細胞癌描出向上におけるCE boost技術の有用性およびboost加算回数が画像に及ぼす影響
    矢部慎二, 祖父江慶太郎, 堀 雅敏, 辻田有志, 山口 尊, 上嶋英介, 上野嘉子, 村上卓道
    第57回日本肝癌研究会, 2021年07月

  • 当院における大動脈解離に伴う腎動脈狭窄に対するステント留置術の中期成績
    小出 裕, 川崎竜太, 松代啓吾, 丸山晃司, 岡田卓也, 山口雅人, 杉本幸司, 村上卓道
    第27回日本血管内治療学会学術総会, 2021年07月

  • 急性期・亜急性期大動脈解離に対するPETTICOAT法のremodeling効果に関する評価
    元津倫幸, 山口雅人, 佐々木康二, モスタファ・ハマダ, 上嶋英介, 岡田卓也, 杉本幸司, 村上卓道, 中井秀和, 山中勝弘, 大村篤史, 岡田健次
    第27回日本血管内治療学会学術総会, 2021年07月

  • 急激に症状が進行する動脈硬化性腎動脈病変に対して経皮的腎動脈形成術(PTRA) を行った2例
    谷 龍一郎, 宮本直和, 津田成康, 田頭 達, 山田愼一郎, 梅野晃弘, 上月瞭平, 難波富美子, 大森美佳, 足立秀治, 粟野考次郎, 冨田 優, 杉本幸司, 村上卓道
    第27回日本血管内治療学会学術総会, 2021年07月

  • シンポジウム8：大動脈ステントグラフト治療成績向上のための挑戦－shaggy aortaの克服を含めて－：EVER時のIMA・LA塞栓術併用による遠隔期治療成績向上の取り組み
    元津倫幸, 山口雅人, 佐々木康二, モスタファ・ハマダ, 上嶋英介, 岡田卓也, 杉本幸司, 村上卓道, 中井秀和, 山中勝弘, 大村篤史, 岡田健次
    第27回日本血管内治療学会学術総会, 2021年07月, 日本語
    シンポジウム・ワークショップパネル（公募）

  • Compressed Sensing-Sensitivity Encoding (CS-SENSE) may improve the image quality of 3D T2-weighted turbo spin-echo imaging in prostate MRI: Preliminary study
    上野嘉子, 祖父江慶太郎, 堀井慎太郎, 島田隆史, 曽宮雄一郎, 西岡瑛子, 浦瀬靖代, 村上卓道
    第80回日本医学放射線学会総会, 2021年04月

  • CE boost技術を用いたダイナミック造影CTにおける多血性肝細胞癌描出能向上の試み
    矢部慎二, 祖父江慶太郎, 堀 雅敏, 上嶋英介, 辻田有志, 山口 尊, 上野嘉子, 村上卓道
    第27回肝血流動態・機能イメージング研究会（Web開催）, 2021年01月

  • Impact of Oncologic Intervention on Tumor Microenvironment
    Murakami T
    Japan-Korea Joint symposium（Web開催／第56回日本肝癌研究会併設）, 2020年12月, 英語
    [招待有り]
    シンポジウム・ワークショップパネル（指名）

  • シンポジウム4：肝内胆管癌診療ガイドラインについて：肝内胆管癌診療ガイドライン（案） 画像診断法について
    藤永康成, 村上卓道, 角谷眞澄
    第56回日本肝癌研究会（Web開催）, 2020年12月

  • シンポジウム4：肝内胆管癌診療ガイドラインについて：CQ解説CQ 1 有効なスクリーニング法はあるか？CQ 2 診断に有用な臨床検査は何か？
    南 康範, 工藤正俊, 杉本勝俊, 糸井隆夫, 藤永康成, 角谷眞澄, 村上卓道
    第56回日本肝癌研究会（Web開催）, 2020年12月

  • 門脈腫瘍栓 Vp2～4 を伴う肝細胞癌に対する術後肝不全予測：EOB-MRI の有用性
    辻田有志, 祖父江慶太郎, 山口 尊, 上嶋英介, 上野嘉子, 小松昇平, 木戸正浩, 福本 巧, 堀 雅敏, 村上卓道
    第56回日本肝癌研究会（Web開催）, 2020年12月

  • 悪性腫瘍の全身FDG PET/MRIにおけるBSREMを用いた高速撮像と診断能の検討
    犬養純子, 野上宗伸, 曽 菲比, 渡邊慶明, 西尾瑞穂, 神田知紀, 祖父江慶太郎, 河野 淳, 久保和広, 村上卓道
    第60回日本核医学会学術総会, 2020年11月

  • 基調講演「CT・MRIによる肝脂肪化の評価」
    村上卓道
    第24回日本肝臓学会大会, 2020年11月, 日本語, 神戸
    [招待有り]
    口頭発表（基調）

  • Combination of ultra-high-resolution computed tomography (U-HRCT) and low tube voltage technique at abdominal CT angiography: phantom study
    Tani W, Negi N, Kusaka A, Hori M, Murakami T
    106th Radiological Society of North America, Scientific Assembly and Annual Meeting (RSNA2020)(Online), 2020年11月

  • Diagnostic Accuracy of Deep Learning with Anomaly Detection for a Small Amount and Highly Biased Dataset: Discrimination of Magnetic Resonance Images between Benign and Malignant Parotid Tumors
    Matsuo H, Kojita Y, Nishio M, Kanda T, Kono A, Otsuki N, Nibu K, Murakami T
    106th Radiological Society of North America, Scientific Assembly and Annual Meeting (RSNA2020)(Online), 2020年11月

  • Association of psoas muscle lean volume measured on dual-energy CT with relative dose intensity in patients with hepatocellular carcinoma treated with Lenvatinib
    Yamaguchi T, Sofue K, Ueshima E, Tsujita Y, Ueno Y, Okada T, Yamaguchi M, Nogami M, Hori M, Murakami T
    106th Radiological Society of North America, Scientific Assembly and Annual Meeting (RSNA2020)(Online), 2020年11月

  • 治療適応の基準を満たさない腎血管筋脂肪腫の破裂
    元津倫幸, 山口雅人, 佐々木康二, Hamada M.A.S, 上嶋英介, 岡田卓也, 祖父江慶太郎, 杉本幸司, 村上卓道
    第30回日本救急放射線研究会（Web開催）, 2020年10月

  • Comparison of the image quality and precision of fused lung images acquired by FDG PET/MRI with ZTE and PET/CT
    Inukai J, Nogami M, Zeng F, Kurimoto T, Murakami T
    33th Annual Congress of the European Association of Nuclear Medicine (EANM 2020)(Online), 2020年10月

  • シンポジウム5：大動脈解離に対するIVR：大動脈解離に対するIVRの現況と課題
    山口雅人, 岡田卓也, 佐々木康二, 元津倫幸, 上嶋英介, 杉本幸司, 村上卓道
    第49回日本IVR学会総会, 2020年08月

  • アンギオ室での急変対応におけるチーム医療～ハートフル チームビルディング～
    小出 裕, 山口雅人, 杉本幸司, 村上卓道
    第49回日本IVR学会総会, 2020年08月

  • シンポジウム4：骨転移疼痛に対する集学的治療－この痛みをどう治療するか－：骨転移に対する骨セメント治療－経皮的椎体形成術の適応を考える－
    岡田卓也, 佐々木康二, Hamada M.A.S, 元津倫幸, 上 英介, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    第49回日本IVR学会総会, 2020年08月

  • 腎動脈瘤に対しバイアバーンを留置した1例
    伊崎健太, 木下知恵子, 池田 覚, 酒井英郎, 杉本幸司, 村上卓道
    第49回日本IVR学会総会, 2020年08月

  • ドセタキセル含浸薬剤溶出性ビーズの基礎的検討
    谷 龍一郎, 岡田卓也, 上嶋英介, 篠原正和, 元津倫幸, 佐々木康二, Hamada M.A, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    第49回日本IVR学会総会, 2020年08月

  • EVAR後の瘤径拡大例に対するトラネキサム酸投与の有用性
    松代啓吾, 川崎竜太, 丸山晃司, 小出 裕, 野村佳克, 山口雅人, 岡田卓也, 杉本幸司, 村上 卓道
    第49回日本IVR学会総会, 2020年08月

  • シンポジウム1：液体塞栓物質（NBCA）を極める！エキスパートへの道：膵領域の急性出血に対するNBCAを用いた動脈塞栓術の検討
    佐々木康二, 岡田卓也, 山口雅人, Hamada M.A.S, 元津倫幸, 上嶋英介, 祖父江慶太郎, 杉本幸司, 村上卓道
    第49回日本IVR学会総会, 2020年08月

  • Diagnostic performance of rapid whole-body FDG PET/MRI in oncology patients: Assessment of optimal beta-value for block sequential regularized expectation maximization (BSREM) reconstruction and combination of whole-body MR sequences
    Inukai J, Nogami M, Zeng F, Watanabe Y, Nishio M, Kanda T, Sofue K, Kono A. Kubo K, Murakami T
    Society of Nuclear Medicine and Molecular Imaging Annual Meeting (SNMMI 2020)(Online), 2020年07月

  • Classification of MR Images between Benign and Malignant Parotid Tumors using Deep Learning
    Matsuo H, Kojita Y, Nishio M, Kanda T, Kono A, Otsuki N, Nibu K, Murakami T
    The 32th Annual Meeting of European Congress of Radiology (ECR 2020)(Online), 2020年07月

  • Clinical applications of dual-energy CT for the quantitative imaging in diffuse liver diseases
    Yamaguchi T, Sofue K, Ueshima E, Tsujita Y, Kanda T, Nogami M, Murakami T
    The 32th Annual Meeting of European Congress of Radiology (ECR 2020)(Online), 2020年07月

  • 膀胱癌診断におけるVI-RADSの妥当性の検討：Likert法との比較
    上野嘉子, 玉田 勉, 竹内 充, 祖父江慶太郎, 髙橋 哲, 上嶋佑樹, 村上卓道
    第79回日本医学放射線学会総会（Web開催）, 2020年05月, 英語, the Japan Radiological Society, Web開催, "[Objective] To evaluate the inter-observer agreement and diagnostic performa nce of Vesical Imaging-Reporting And Data System (VI-RADS) for muscle-invasi ve bladder cancer (MIBC) , in comparison with Likert scale.[Materials and Me thods] A total of 111 consecutive patients who had undergone mp-MRI before t rans-urethral resection of bladder tumor participated in this study. Five re aders retrospectively assessed the probability of the presence of MIBCs with Likert and VI-RADS scores. The inter-observer agreement was assessed by mea suring intraclass correlation coefficients (ICC). Receiver operating charact eristic (ROC) analysis was used to evaluate the diagnostic performance for M IBCs. Areas under the ROC curves (AUC) were estimated for ordinal score asse ssments.[Results] Out of 111 patients, 57 had MIBCs. Inter-observer agreemen t was excellent for Likert and VI-RADS scores (ICC; 0.81 vs 0.81). AUCs show ed no significant difference between the Likert and VI-RADS scores for all r eaders (P>0.05). [Conclusion] The VI-RADS score showed an excellent inter -observer agreement and high diagnostic performance for MIBCs equivalent to the Likert scale. ", 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 単純結節周囲増殖型、多結節融癒合型、低文化の病態と悪性度－TACE治療の観点から－ 肝細胞癌の画像による肉眼分類・腫瘍分化度の臨床判断
    Shimada R, Sofue K, Kyotani K, Wang T, Ueno Y, Ishihara T, Horii S, Nogami M, Kusaka A, Murakami T
    肝臓内科×放射線科 座談会, 2020年03月, 日本語, 株式会社エーザイ, 大阪, 日本国, 国内会議
    [招待有り]
    その他

  • 特別講演「肝疾患の画像診断・評価の最近の話題：LI-RADSver.2018 CT/MRI, Dual-Energy CT」
    村上卓道
    肝疾患の画像診断・評価アップデート, 2020年01月, 日本語, 国内会議
    [招待有り]
    口頭発表（招待・特別）

  • 教育講演「肝細胞癌の画像診断」
    村上卓道
    2019年度日本肝臓学会後期教育講演会, 2019年12月, 日本語
    [招待有り]
    公開講演，セミナー，チュートリアル，講習，講義等

  • 教育講演「放射線医療におけるAIの役割を考える」
    村上卓道
    日本放射線技術学会近畿支部 第63回学術大会, 2019年12月, 日本語
    [招待有り]
    公開講演，セミナー，チュートリアル，講習，講義等

  • 脊柱管内進展を伴った脊椎骨転移に対する経皮的椎体形成術の検討
    岡田卓也, 佐々木康二, 角谷賢一郎, 宮脇大輔, 元津倫幸, 上嶋英介, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    第9回緩和IVR研究会, 2019年12月, 日本語, 東京, 国内会議
    口頭発表（一般）

  • Prediction of Pancreatic Atrophy after Steroid Therapy in Autoimmune Pancreatitis using Extracellular Volume Fraction in Contrast-Enhanced Computed Tomography
    Sofue K, Masuda A, Yamada Y, Yamaguchi T, Tsujita Y, Ueshima E, Ueno Y, Nogami M, Murakami T
    105th Radiological Society of North America, Scientific Assembly and Annual Meeting (RSNA2019), 2019年12月

  • Development and Assessment of Respiratory Motion-Resolved Hepatobiliary Phase Cine-MRI using Compressed SENSE for Stereotactic Body Radiotherapy in Liver Tumor
    Shimada R, Sofue K, Kyotani K, Wang T, Ueno Y, Ishihara T, Horii S, Nogami M, Kusaka A, Murakami T
    105th Radiological Society of North America, Scientific Assembly and Annual Meeting (RSNA2019), 2019年12月

  • Utility of Extracellular Volume Fraction Measured from Multiphasic Contrast-Enhanced Computed Tomography for the Estimation of Pancreatic Fibrosis
    Sofue K, Ueno Y, Ueshima E, Tani R, Horinouchi H, Maruyama K, Okada T, Yamaguchi M, Sugimoto K, Murakami T
    105th Radiological Society of North America, Scientific Assembly and Annual Meeting (RSNA2019), 2019年12月

  • 膵腫瘍と鑑別が困難であった脾動脈解離にともなった仮性動脈瘤の一例
    田原潤子, 辻田有志, 祖父江慶太郎, 山口 尊, 神田知紀, 岡田卓也, 河野 淳, 前田隆樹, 野上宗伸, 山口雅人, 杉本幸司, 村上卓道
    第323回日本医学放射線学会関西地方会, 2019年11月, 国内会議
    口頭発表（一般）

  • 肝切除後胆管閉塞に対し非解剖学経路で経皮的胆道形成を施行した1例
    堀之内宏樹, 上嶋英介, 杉本幸司, 祖父江慶太郎, 佐々木康二, MAS Hamada, 元津倫幸, 岡田卓也, 山口雅人, 村上卓道
    第26回兵庫県IVR懇話会, 2019年11月, 国内会議
    口頭発表（一般）

  • 腎血管筋脂肪種と診断してTAEを行った一例
    河野泰秀, 岡田卓也, 渡邊早奈絵, 後藤 一, 岩間祐基, 杉本幸司, 村上卓道
    第26回兵庫県IVR懇話会, 2019年11月, 国内会議
    口頭発表（一般）

  • シンポジウム：最新のエビデンスに基づくステントグラフと治療の現況と課題「大動脈解離」
    山口雅人, 岡田卓也, 元津倫幸, 佐々木康二, 堀之内宏樹, 杉本幸司, 村上卓道
    第55回日本医学放射線学会秋期臨床大会, 2019年10月
    シンポジウム・ワークショップパネル（指名）

  • 当院における脾動脈瘤に対する動脈塞栓術の治療成績
    岡田卓也, 佐々木康二, Hamada Mostafa, 堀之内宏樹, 元津倫幸, 上嶋英介, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    第60回日本脈管学会総会, 2019年10月
    シンポジウム・ワークショップパネル（公募）

  • 特別企画「日本脈管学会認定脈管専門医制度を考える」
    村上卓道
    第60回日本脈管学会総会, 2019年10月, 日本語
    [招待有り]
    口頭発表（招待・特別）

  • Iliac Branch Endoprosthesisを用いたステントグラフと内挿術の初期成績
    元津倫幸, 山口雅人, Hamada Mostafa, 佐々木康二, 堀之内宏樹, 上嶋英介, 岡田卓也, 祖父江慶太郎, 後竹康子, 中井秀和, 山中勝弘, 大村篤史, 岡田健次, 杉本幸司, 村上卓道
    第60回日本脈管学会総会, 2019年10月
    口頭発表（一般）

  • 3D-Imaging for Liver Cirrhosis and Portal Hypertension
    Murakami T
    JSH International Liver Conference 2019, 2019年10月

  • 特別講演「EOB-MRIのoverview」
    村上卓道
    第二回Advanced Diagnostic Imaging Conference in Hamamatsu, 2019年10月, 日本語
    [招待有り]
    口頭発表（招待・特別）

  • 特別講演「肝機能画像診断とAIの役割」
    村上卓道
    第11回伊丹・尼崎肝疾患懇話会, 2019年10月, 日本語
    [招待有り]
    口頭発表（招待・特別）

  • Application of hierarchical clustering to multi-parametric MR in prostate: Explainable machine learning techinique
    Akamine Y, Ueda Y, Ueno Y, Sofue K, Murakami T, Yneyama M, Obara M, Cauteren MV
    第47回日本磁気共鳴医学会大会, 2019年09月
    ポスター発表

  • Denoising parameter dependence of prostate 3D T2 weighted images in Compressed Sensing MRI
    Horii S, Kyotani K, Somiya H, Shimada R, Yoshida N, Noda T, Murakami T
    第47回日本磁気共鳴医学会大会, 2019年09月
    口頭発表（一般）

  • Liver MRI using Compressed Sensing; Respiratory Motion-Resolved Hepatobiliary Phase Cine-MRI
    Shimada R, Kyotani K, Sofue K, Horii S, Somiya H, Wang T, Ishihara T, Murakami T
    第47回日本磁気共鳴医学会大会, 2019年09月
    口頭発表（一般）

  • 筋腫分娩様の所見を呈し、術前診断が困難であった子宮平滑筋肉腫の1例
    犬養純子, 浦瀬靖代, 神田知紀, 上野嘉子, 田中宇多留, 祖父江慶太郎, 前田隆樹, 野上宗伸, 松本培世, 蝦名康彦, 寺井義人, 原 重雄, 今岡いずみ, 石井一成, 村上卓道
    The 20th Annual Symposium Japanese Society for the Advancement of Women’s Imaging (JSAWI2019), 2019年09月
    口頭発表（一般）

  • 卵巣腫瘍と鑑別を要した肝細胞癌の骨盤内播
    峯 凪り, 小路田泰之, 神田知紀, 浦瀬靖代, 上野嘉子, 祖父江慶太郎, 前田隆樹, 野上宗伸, 寺井義人, 山田秀人, 原 重雄, 村上卓道
    The 20th Annual Symposium Japanese Society for the Advancement of Women’s Imaging (JSAWI2019), 2019年09月
    口頭発表（一般）

  • 特別講演「Li-RADSの紹介と肝細胞癌の治療効果判定」
    村上卓道
    第18回Radiology Seminar Izumo, 2019年09月, 日本語
    [招待有り]
    口頭発表（招待・特別）

  • Case Discussion. Session: Diagnosis and staging of HCC. APPLE Academy 2019
    Murakami T
    The 10th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE2019), 2019年08月
    口頭発表（招待・特別）

  • Imaging diagnosis of HCC. Session: Diagnosis and staging of HCC. APPLE Academy 2019
    Murakami T
    The 10th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE2019), 2019年08月
    口頭発表（招待・特別）

  • 特別講演「肝臓 EOB-MRIのoverview」
    村上卓道
    第4回富山画像診断講演会, 2019年07月, 日本語
    [招待有り]
    口頭発表（招待・特別）

  • 腫瘍・血栓の画像診断の進歩とAIの役割
    村上卓道
    Onco-Cardiology フォーラム in 淡路～Cancer VTE 診断から治療まで～, 2019年07月, 日本語
    シンポジウム・ワークショップパネル（指名）

  • 肝画像診断の進歩と治療への応用
    村上卓道
    第9回大阪神戸放射線医学研究会, 2019年07月

  • 特別講演「画像診断の進歩とAIの役割」
    村上卓道
    Meet the Expert 2019, 2019年07月, 日本語
    [招待有り]
    口頭発表（招待・特別）

  • 特別講演「専門医制度の動向とAI画像診断と放射線科医の関り」
    村上卓道
    第36回飛鳥放射線医学セミナープログラム, 2019年07月, 日本語
    [招待有り]
    公開講演，セミナー，チュートリアル，講習，講義等

  • 頭部MRIで広範囲な病変を認めた自己免疫性脳炎の1例
    田中千暁, 小路田泰之, 神田知紀, 上野嘉子, 岡田卓也, 祖父江慶太郎, 前田隆樹, 野上宗伸, 山口雅人, 杉本幸司, 村上卓道
    第322回日本医学放射線学会関西地方会, 2019年06月, 日本語, 国内会議
    口頭発表（一般）

  • 当院における大動脈解離に対するTEVARの治療成績
    岡田卓也, 山口雅人, 佐々木康二, 堀之内宏樹, 元津倫幸, 谷龍一郎, 上嶋英介, 小出裕, 祖父江慶太郎, 後竹康子, 中井秀和, 山中勝弘, 岡田健次, 杉本幸司, 村上卓道
    第48回日本IVR学会総会, 2019年05月, 日本語, JSIR, 福岡, 国内会議
    口頭発表（一般）

  • TAE for postpartum hemorrhage due to genital tract injury after vaginal delivery
    佐々木康二, 岡田卓也, Mostafa Hamada, 元津倫幸, 堀之内宏樹, 谷 龍一郎, 上嶋英介, 小出 裕, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    第48回日本IVR学会総会, 2019年05月, 日本語, 国内会議
    口頭発表（一般）

  • Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績
    元津倫幸, 山口雅人, 佐々木康二, 堀之内宏樹, 谷 龍一郎, 上嶋英介, 小出 裕, 岡田卓也, 祖父江慶太郎, 杉本幸司, 村上卓道, 後竹康子, 中井秀和, 山中勝弘, 岡田健次
    第48回日本IVR学会総会, 2019年05月, 日本語, 国内会議
    口頭発表（一般）

  • 特別講演「LI-RADSの紹介と肝細胞癌に対する分子標的治療薬の画像効果判定」
    村上卓道
    肝癌化学療法セミナー, 2019年06月, 日本語
    口頭発表（招待・特別）

  • 特別講演「画像診断の進歩とAIの役割」
    村上卓道
    県立姫路循環器病センター院内学術講演会, 2019年06月, 日本語
    口頭発表（招待・特別）

  • Malignant Primary Liver Tumors
    Murakami T
    Asian Congress of Abominal Radiology, 2019年05月, 英語, Chengdu

  • Malignant Primary Liver Tumors
    Murakami T
    International Society for Magnetic Resonance in Medicine (ISMRM 2019), 2019年05月

  • Long-term Outcome of Transarterial Embolization for Type II Endoleakafter Endovascular Abdominal Aortic Aneurysm Repair
    Horinouchi H, Yamaguchi M, Okada T, Sasaki K, Gentsu T, Gotake Y, Okada K, Sugimoto K, Murakami T
    Global Embolization Cancer Symposium Technologies (GEST2019), 2019年05月

  • 骨盤画像の基礎知識
    村上卓道
    第107回日本泌尿器科学会総会, 2019年04月, 日本語
    口頭発表（招待・特別）

  • 特別講演「肝EOB・造影MRIのoverview」
    村上卓道
    第59回滋賀MRI研究会, 2019年03月, 日本語, 草津, 国内会議
    [招待有り]
    口頭発表（招待・特別）

  • 肝細胞癌に対する放射線照射治療後の経動脈的化学塞栓療法の安全性の検討
    上嶋英介, 岡田卓也, 山口雅人, 杉本幸司, 村上卓道, 西尾福英之, 田中利洋, 吉川公彦, 高木治行, 児玉大志, 山門亨一郎
    第19回関西肝癌局所療法研究会, 2019年03月, 日本語, 国内会議
    口頭発表（一般）

  • Multi-Parametric Approach Among CEST Imaging, DWI and FDG-PET/CT for Diagnosis of Solitary Pulmonary Nodule
    Ohno Y, Yui M, Kishida Y, Seki S, Kyotani K, Yoshikawa T, Murakami T
    The 31st Annual Meeting of European Congress of Radiology (ECR 2019), 2019年02月

  • Inspiratory/Expiratory Xenon-Enhanced Area-Detector CT with 3D Motion Analysis: Utility for Pulmonary Functional Loss Assessment and Clinical Stage Classification of COPD
    Ohno Y, Fujisawa Y, Sugihara N, Kishida Y, Seki S, Yoshikawa T, Koyama H, Murakami T
    The 31st Annual Meeting of European Congress of Radiology (ECR 2019), 2019年02月

  • Inspiratory/ Expiratory 3D Pulmonary MR Imaging with UTE: Capability for Pulmonary Functional Loss Assessment and Clinical Stage Classification in Smokers as Compared with Thin-Section CT
    Ohno Y, Yui M, Kishida Y, Seki S, Yoshikawa T, Murakami T
    The 31st Annual Meeting of European Congress of Radiology (ECR 2019), 2019年02月

  • Comparison of Therapeutic Outcome Prediction between Perfusion Matrix on Dynamic Perfusion Area-Detector CT (ADCT) and MRI and FDG-PET/CT in Small Cell Lung Cancer Patients with Limited Disease
    Ohno Y, Fujisawa Y, Yui M, Kishida Y, Seki S, Yoshikawa T, Murakami T
    The 31st Annual Meeting of European Congress of Radiology (ECR 2019), 2019年02月

  • Comparison of Quantitative Capability among DWI with FASE and EPI Sequence at 1.5T or 3T Systems and FDG-PET/CT: for Differentiating Malignant from Benign Solitary Pulmonary Nodules
    Ohno Y, Yui M, Lee HY, Koyama H, Kishida Y, Seki S, Yoshikawa T, Kassai Y, Murakami T
    The 31st Annual Meeting of European Congress of Radiology (ECR 2019), 2019年02月

  • Comparison of Capability for TNM Stage Assessment among Whole-Body MRI and PET/MRI at Different Field Strength and FDG-PET/CT in Non-Small Cell Lung Cancer
    Ohno Y, Aoyagi K, Yui M, Kishida Y, Seki S, Yoshikawa T, Murakami T
    The 31st Annual Meeting of European Congress of Radiology (ECR 2019), 2019年02月

  • Comparison of Capability for Nodule Component Measurement and Management on Follow-Up CT Examinations between 3D CADv Systems with and without CNN
    Ohno Y, Yaguchi A, Aoyagi K, Kishida Y, Seki S, Ueno Y, Yoshikawa T, Murakami T
    The 31st Annual Meeting of European Congress of Radiology (ECR 2019), 2019年02月

  • 3D Oxygen-Enhanced MRI at 3T System versus Thin-Section CT: Quantitative Capability for Pulmonary Functional Loss Assessment and Clinical Stage Classification in Smokers
    Ohno Y, Yui M, Kishida Y, Seki S, Yoshikawa T, Murakami T
    The 31st Annual Meeting of European Congress of Radiology (ECR 2019), 2019年02月

  • 3D Computer-Aided CT Texture Analysis with Machine Learning: Capability to Play as Second Reader for Radiological Finding Assessment in Patients with Interstitial Lung Disease
    Ohno Y, Yaguchi A, Takenaka D, Yoshikawa T, Kishida Y, Seki S, Murakami T
    The 31st Annual Meeting of European Congress of Radiology (ECR 2019), 2019年02月

  • 特別講演「画像診断の進歩とAIの役割を考える」
    村上卓道
    西宮市内科医科学術講演会, 2019年02月, 日本語
    口頭発表（招待・特別）

  • 肝動脈塞栓術は免疫抑制性サイトカイン発現に与える影響 ~ラット肝癌モデルによる検討~
    上嶋英介, 小出 裕, M.A.S. Hamada, 堀之内宏樹, 岡田卓也, 佐々木康二, 元津倫幸, 谷 龍一郎, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    第1回宮崎関西放射線研究会, 2019年02月, 日本語, 国内会議
    [招待有り]
    口頭発表（招待・特別）

  • AIと放射線診断医の関わりを考える SessionⅡ 近未来医療におけるAIの役割
    村上卓道
    神戸医療連携セミナー, 2019年01月, 日本語, 神戸, 国内会議
    口頭発表（一般）

  • AIと放射線診断医の関わりを考える
    村上卓道
    教育研究委員会後期研修会, 2019年01月, 日本語, 神戸, 国内会議
    [招待有り]
    口頭発表（一般）

  • 特別講演「肝の最新画像 診断と治療への応用」
    村上卓道
    第69回なにわ臨床画像研究会, 2019年01月, 日本語, 国内会議
    [招待有り]
    口頭発表（招待・特別）

  • 特別講演「分子標的治療薬の画像的効果判定」
    村上卓道
    Lenvatinib Meet The Experts in Hyogo, 2019年01月, 日本語
    [招待有り]
    口頭発表（招待・特別）

  • 肺結節の良・悪性鑑別診断におけるComputed DWIとPET/CTとの比較検討
    岸田雄治, 大野良治, 油井正生, 葛西由守, 関 紳一郎, 吉川 武, 村上卓道
    第11回呼吸機能イメージング研究会学術集会, 2019年01月, 日本語, 国内会議
    口頭発表（一般）

  • 当院における経腟分娩後の産道出血に対する動脈塞栓術の検討
    佐々木康二, 岡田卓也, ハマダ モスタファ, 元津倫幸, 谷 龍一郎, 上嶋英介, 小出 裕, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    兵庫県IVR懇話会, 2018年11月, 日本語, 国内会議
    口頭発表（一般）

  • Gd－EOB－DTPA造影MRIのoverview
    村上卓道
    第51回高知県放射線科医会総会学術講演会, 2018年11月, 日本語, 国内会議
    口頭発表（招待・特別）

  • What Radiologists Need to Focus on Renal Imaging for Preventing Pathological Upstaging of Clinical T1 to Pathological T3 Renal Cancer Managed by Partial Nephrectomy
    Takahashi S, Ueno Y, Negi N, Kagawa K, Tanaka U, Murakami T
    104th Radiological Society of North America, Scientific Assembly and Annual Meeting (RSNA2018), 2018年11月, 英語, Chicago, 国際会議
    ポスター発表

  • Comparison of TNM Stage Evaluation Capability among Whole-Body MRI at 1.5T and 3T MR Systems, PET/MRI at 1.5T and 3T MR Systems and PET/CT in Non-small Cell Lung Cancer Patients
    Ohno Y, Kishida Y, Seki S, Yoshikawa T, Aoyaki K, Yui M, Koyama H, Murakami T
    104th Radiological Society of North America, Scientific Assembly and Annual Meeting (RSNA2018), 2018年11月, 英語, Chicago, 国際会議
    ポスター発表

  • Solitary Pulmonary Nodules: Comparison of Differentiation Capability Among Actual Diffusion-Weighted Imaging and Computed Diffusion-Weighted Imaging at Different b Values and FDG-PET/CT
    Kishida Y, Ohno Y, Yui M, Kassai Y, Seki S, Yoshikawa T, Kyotani K, Murakami T
    104th Radiological Society of North America, Scientific Assembly and Annual Meeting (RSNA2018), 2018年11月, 英語, Chicago, 国際会議
    ポスター発表

  • Whole-Lung Dynamic Contrast-Enhanced Perfusion Area-Detector CT: Capability for Pulmonary Function Assessment and Morphological Change Evaluation in Stage IA Non-Small Cell Lung Cancer
    Ohno Y, Fujisawa Y, Sugihara N, Kishida Y, Seki S, Yoshikawa T, Murakami T
    104th Radiological Society of North America, Scientific Assembly and Annual Meeting (RSNA2018), 2018年11月, 英語, Chicago, 国際会議
    ポスター発表

  • Utility of extracellular volume fraction measured from multiphasic contrast-enhanced computed tomography for the estimation of pancreatic fibrosis
    Sofue K, Ueno Y, Tani R, Horinouchi H, Maruyama K, Ueshima E, Okada T, Yamaguchi M, Sugimoto K, Murakami T
    104th Radiological Society of North America, Scientific Assembly and Annual Meeting (RSNA2018), 2018年11月, 英語, Chicago, 国際会議
    ポスター発表

  • Comparison of total gadolinium retention in human bone tissue after injection of gadoterate meglumine versus gadodiamide in patients with normal renal function
    Maeda T, Hara H, Akisue T, Kuroda R, Fujii M, Murakami T
    104th Radiological Society of North America, Scientific Assembly and Annual Meeting (RSNA2018), 2018年11月, 英語, Chicago, 国際会議
    ポスター発表

  • New and updated topics in targeted therapies for the treatment of advanced and metastatic renal cell carcinoma: What radiologists should know
    Ueno Y, Tamada T, Takahashi S, Sofue K, Tanaka U, Murakami T
    104th Radiological Society of North America, Scientific Assembly and Annual Meeting (RSNA2018), 2018年11月, 英語, Chicago, 国際会議
    ポスター発表

  • IMA閉塞例におけるEVAR後のType2エンドリークの検討 予防的IMA塞栓術は有用か？
    岡田卓也, 元津倫幸, 山口雅人, 佐々木康二, ハマダモスタファ, 谷 龍一郎, 上嶋英介, 小出 裕, 祖父江慶太郎, 杉本幸司, 村上卓道, 後竹康子, 中井秀和, 山中勝弘, 田中裕史
    第59回日本脈管学会総会, 2018年10月, 日本語, 広島, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 翼口蓋窩に生じた筋上皮腫の1例
    立花美保, 神田知紀, 田中宇多留, 上野嘉子, 祖父江慶太郎, 前田隆樹, 野上宗伸, 村上卓道, 神澤真紀, 伊藤智雄
    第54回日本医学放射線学会秋季臨床大会（第31回頭頸部放射線研究会）, 2018年10月, 日本語, 国内会議
    口頭発表（一般）

  • Dual energy CT for Liver Imaging
    Murakami T
    SVR X BASE 2018, 2018年10月, 英語, Bayer Korea, Seoul, 国際会議
    口頭発表（招待・特別）

  • 肝画像診断の進歩と治療への応用
    村上卓道
    第26回鹿児島画像診断カンファレンス, 2018年10月, 日本語, 国内会議
    口頭発表（招待・特別）

  • EVAR術前のIMA/LA塞栓
    佐々木康二, 山口雅人, 元津倫幸, ハマダモスタファ, 谷 龍一郎, 上嶋英介, 小出 裕, 岡田卓也, 祖父江慶太郎, 杉本幸司, 村上卓道
    兵庫Coil Embolization Conference, 2018年10月, 日本語, 国内会議
    公開講演，セミナー，チュートリアル，講習，講義等

  • シミュレーションからナビゲーション：放射線領域での技術の到達点と今後の展望
    鶴﨑正勝, 工藤正俊, 村上卓道
    第13回肝癌治療シミュレーション（ナビゲーション）研究会, 2018年09月, 日本語, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 乏血性結節の診断とマネージメント
    村上卓道
    第46回日本磁気共鳴医学会大会 (JSMRM2018), 2018年09月, 日本語, 国内会議
    口頭発表（招待・特別）

  • 妊娠を契機に発見され、MRIにて術前診断された卵巣線維腫症の一例
    浦瀬靖代, 神田知紀, 上野嘉子, 田中宇多留, 今福仁美, 山田秀人, 谷 明穂, 神澤真紀, 村上 卓道
    第19回JSAWI, 2018年09月, 日本語, 淡路, 国内会議
    ポスター発表

  • 腎腫瘍のPET: 画像と病理所見との対比
    上野嘉子, 野上宗伸, 山崎 隆, 祖父江慶太郎, 髙橋 哲, 田中宇多留, 寺川智章, 日向信之, 藤澤正人, 伊藤智雄, 村上卓道
    第6回 泌尿器画像診断・治療技術研究会, 2018年09月, 日本語, Japanese Society of Uroradiologic and Therapeutic Technology (JSURT), 京都, 国内会議
    口頭発表（一般）

  • 肝腫瘍画像診断の進歩と治療への応用
    村上卓道
    Autumn Seminar in IZUMO, 2018年09月, 日本語, 島根大学医学部附属病院放射線科, 出雲, 国内会議
    口頭発表（招待・特別）

  • 妊娠を契機に発見され、MRIにて術前診断された卵巣線維腫症の一例
    浦瀬靖代, 神田知紀, 上野嘉子, 田中宇多留, 今福仁美, 山田秀人, 谷 明穂, 神澤真紀, 村上卓道
    第19回JSAWIシンポジウム2019, 2018年08月, 日本語, Japanese Society for the Advancement of Womens' Imaging (JSAWI), 淡路, 国内会議
    口頭発表（一般）

  • フォーラム「肝画像診断の進歩とIVR治療への応用」
    村上卓道
    神鋼記念病消化器センターフォーラム, 2018年07月, 日本語, 神戸, 国内会議
    その他

  • サテライトシンポジウム「肝腫瘍の画像診断：最新情報を含めて」
    村上卓道
    第59回栃木県放射線科医会, 2018年07月, 日本語, 栃木, 国内会議
    シンポジウム・ワークショップパネル（指名）

  • Retinal Vasculopathy with Cerebral leukoencephalopathy (RVCL) の一例
    田中千賀, 神田知紀, 上野嘉子, 岡田卓也, 祖父江慶太郎, 前田隆樹, 野上宗伸, 山口雅人, 杉本幸司, 村上卓道
    第51回兵庫県磁気共鳴医学研究会, 2018年07月, 日本語, 兵庫県放射線医会, 神戸, 国内会議
    口頭発表（一般）

  • 悪性腫瘍を対象としたFDG PET/MRにおけるZero TE法による肺野病変の評価
    野上宗伸, 曽 菲比, 栗本貴子, 久保和広, 村上卓道
    第51回日本核医学近畿地方会, 2018年07月, 日本語, Japanese Society of Nuclear Medicine (JSNM), 和歌山, 国内会議
    口頭発表（一般）

  • 肝画像診断の進歩
    村上卓道
    宮崎放射線科医会・宮崎県画像医学研究会合同学術講演会, 2018年07月, 日本語, 宮崎, 国内会議
    口頭発表（招待・特別）

  • 画像診断の進歩とAIの必要性
    村上卓道
    兵庫県立柏原病院第2回オープンセミナー, 2018年07月, 日本語, 丹波, 国内会議
    口頭発表（招待・特別）

  • 肝画像診断の進歩とIVR治療への応用
    村上卓道
    第39回播淡画像診断研究会, 2018年07月, 日本語, 神戸, 国内会議
    口頭発表（招待・特別）

  • Prediction of fibroglandular density and breast dose based on physical characteristics and lifestyle habits
    Yamamuro M, Asai Y, Yamada K, Ozaki Y, Matsumoto M, Murakami T
    International Union for Physical and Engineering Sciences in Medicine (IUPESM) 2018, 2018年06月, 英語, International Union for Physical and Engineering Sciences in Medicine, Prague, 国際会議
    口頭発表（一般）

  • Development of fibroglandular-variable breast phantom and its application to quantitative assessment of undetectable lesion rate in digital mammography
    Yamamuro M, Asai Y, Yamada K, Ozaki Y, Matsumoto M, Murakami T
    International Union for Physical and Engineering Sciences in Medicine (IUPESM) 2018, 2018年06月, 英語, International Union for Physical and Engineering Sciences in Medicine (IUPESM), Prague, 国際会議
    口頭発表（一般）

  • 教育講演「肝細胞癌の画像治療効果判定」
    村上卓道
    第54回日本肝臓学会総会, 2018年06月, 日本語, 大阪, 国内会議
    シンポジウム・ワークショップパネル（指名）

  • シンポジウム「肝内胆管癌: 臨床診断」
    工藤正俊, 角谷真澄, 村上卓道, 糸井隆夫, 海野倫明
    第54回日本肝癌研究会, 2018年06月, 日本語, 久留米, 国内会議
    シンポジウム・ワークショップパネル（指名）

  • 線維軟骨塞栓症が疑われた若年者脊髄梗塞の一例
    藤原康弘, 神田知紀, 上野嘉子, 岡田卓也, 祖父江慶太郎, 前田隆樹, 野上宗伸, 山口雅人, 杉本幸司, 村上卓道, 大塚喜久
    第319回日本医学放射線学会関西地方会, 2018年06月, 日本語, 大阪, 国内会議
    口頭発表（一般）

  • シンポジウム「RFA 治療の効果測定：Hepatic Guideの有効性 」（パネルディスカッション５「画像人団の新展開」）
    南 知宏, 村上卓道, 工藤正俊
    第54回日本肝臓学会総会, 2018年06月, 日本語, The Japan Society of Hepatology, 大阪, 国内会議
    シンポジウム・ワークショップパネル（指名）

  • パネルディスカッション「Gd-EOB-DTPA-MRI による肝細胞癌診断 overview」
    村上卓道
    神戸放射線科医学学術交流会, 2018年06月, 日本語, 神戸, 国内会議
    シンポジウム・ワークショップパネル（指名）

  • パネルディスカッション「肝内胆管癌: 臨床診断」
    工藤正俊, 角谷真澄, 村上卓道, 糸井隆夫, 海野倫明
    第54回日本肝癌研究会, 2018年06月, 日本語, 日本肝癌研究会, 久留米, 国内会議
    シンポジウム・ワークショップパネル（指名）

  • 肝細胞癌に対する呼吸同期粒子線治療のための経動脈的マーカー留置術の安全性と有用性の評価
    元津倫幸, 寺嶋千貴, 松尾圭朗, 永野史子, 出水祐介, 徳丸直郎, 沖本智昭, 杉本幸司, 村上卓道
    第54回日本肝癌研究会, 2018年06月, 日本語, 日本肝癌研究会, 久留米, 国内会議
    口頭発表（一般）

  • 破裂性十二指腸静脈瘤に対してバルーン閉塞下逆行性静脈瘤塞栓術を施行した一例
    小出 裕, 岡田卓也, 佐々木康二, 元津倫幸, Hamada MAS, 谷 龍一郎, 上嶋英介, 祖父江慶太郎, 村上卓道
    第65回関西IVR研究会, 2018年06月, 日本語, Japanese Society of Interventional Radiology (JSIR), 大阪, 国内会議
    口頭発表（一般）

  • 肝動脈塞栓術がTGF-β発現に与える影響：ラット肝癌モデルによる検討
    上嶋英介, 岡田卓也, 山口雅人, 杉本幸司, 村上卓道, 西尾福英之, 田中利洋, 吉川公彦, 高木治行, 児玉大志, 山門亨一郎
    第65回関西IVR研究会, 2018年06月, 日本語, Japanese Society of Interventional Radiology (JSIR), 大阪, 国内会議
    口頭発表（一般）

  • 肝細胞癌の画像治療効果判定
    村上卓道
    第54回日本肝臓学会総会, 2018年06月
    公開講演，セミナー，チュートリアル，講習，講義等

  • Guidelines for diagnosis of hepatocellular carcinoma
    Murakami T
    Japanese-German Radiological Affiliation. 19th workshop. Bi-Annual Meeting, 2018年05月, 英語, Japanese-German Radiological Affiliation (JGRA), Okayama, 国際会議
    シンポジウム・ワークショップパネル（指名）

  • Embolization for acute hemorrhage in patients with head and neck cancer
    Koide Y, Okada T, Mostafa H, Sasaki K, Maruyama K, Horinouchi H, Gentsu T, Tani R, Ueshima E, Sofue K, Yamaguchi M, Sugimoto K, Murakami T
    The The 47th Annual Meeting of the Japanese Society of Interventional Radiology & the 13th international symposium of interventional radiology, 2018年05月, 英語, Japanese Society of Interventional Radiology (JSIR), Tokyo, 国際会議
    口頭発表（一般）

  • The feasibility of preoperative embolization for partial resection of hypervascular spinal tumor
    Tani R, Ueshima E, Hamada M, Sasaki K, Maruyama K, Horinouch H, Gentsu T, Koide Y, Okada T, Sofue K, Yamaguchi M, Sugimoto K, Murakami T
    The 47th Annual Meeting of the Japanese Society of Interventional Radiology & the 13th international symposium of interventional radiology, 2018年05月, 英語, Japanese Society of Interventional Radiology (JSIR), Tokyo, 国際会議
    口頭発表（一般）

  • Embolization with NBCA for acute bleeding from pancreatic and peripancreatic arteries
    Sasaki K, Okada T, Mostafa H, Maruyama K, Horinouchi H, Gentsu T, Tani R, Ueshima E, Koide Y, Sofue K, Yamaguchi M, Sugimoto K, Murakami T
    The 47th Annual Meeting of the Japanese Society of Interventional Radiology & the 13th international symposium of interventional radiology, 2018年05月, 英語, Japanese Society of Interventional Radiology (JSIR), Tokyo, 国際会議
    口頭発表（一般）

  • Neoplastic lesions in the non-cirrhotic liver (non-cystic)
    Murakami T
    Asian Society of Abdominal Radiology, Educational Lecture Course, 2018年05月, 英語, Asian Society of Abdominal Radiology (ASAR), Singapore, 国際会議
    口頭発表（招待・特別）

  • Dual / spectral CT: role in liver imaging
    Murakami T
    Asian Society of Abdominal Radiology, Invited lecture, 2018年05月, 英語, SingEx, Singapore, 国際会議
    [招待有り]
    口頭発表（招待・特別）

  • 術前診断が困難であった副腎血管肉腫の1例
    宮崎亜樹, 上野嘉子, 田中宇多留, 祖父江慶太郎, 髙橋 哲, 日向信之, 藤澤正人, 原 重雄, 藤倉航平, 伊藤智雄, 村上卓道
    第32回日本腹部放射線学会, 2018年05月, 日本語, 鎌倉, 国内会議
    口頭発表（一般）

  • Cine MRIを用いた閉経後女性の子宮蠕動の評価
    山川美帆, 今岡いずみ, 兵頭朋子, 沼本勲男, 小田晃義, 川本誠一, 村上卓道
    第77回日本医学放射線学会総会, 2018年04月, 日本語, 横浜, 国内会議
    口頭発表（一般）

  • 核医学イメージングを用いての前立腺癌の再発や転移診断
    甲斐田勇人, 石井一成, 細川知紗, 山田 穣, 細野 眞, Rominger A, Bartenstein P, 村上卓道
    第77回日本医学放射線学会総会, 2018年04月, 日本語, 横浜, 国内会議
    口頭発表（一般）

  • 肝画像診断の進歩と治療への応用
    村上卓道
    神緑会北支部総会学術講演会, 2018年03月, 日本語, 神戸, 国内会議
    口頭発表（招待・特別）

  • 肝癌の最新画像診断と治療への応用
    村上卓道
    奈良県医師会放射線部会学術講演会, 2018年03月, 日本語, 奈良, 国内会議
    口頭発表（招待・特別）

  • 子宮広間膜に発生した平滑筋肉種の一例
    宮﨑亜樹, 上野嘉子, 田中宇多留, 祖父江慶太郎, 村上卓道, 原 重雄, 藤倉航平, 伊藤智雄, 蝦名康彦, 山田秀人, 前田哲雄
    第318回日本医学放射線学会関西地方会, 2018年02月, 日本語, 大阪, 国内会議
    口頭発表（一般）

  • バッドキアリ症候群に伴う急性肝不全に対して肝移植までのBridging therapyとしてTIPSを施工した1例
    沼本勲男, 鶴﨑正勝, 小田晃義, 柳生行伸, 鈴木絢子, 土居秀平, 柏木伸夫, 村上卓道, 上嶋一臣, 工藤正俊
    第63回中部・第64回関西IVR合同研究会, 2018年02月, 日本語, 長久手, 国内会議
    口頭発表（一般）

  • 術後膵液漏による腹腔動脈仮性瘤に対し、VIABAHNにより肝血流が温存可能であった1例
    小田晃義, 鶴﨑正勝, 沼本勲男, 柳生行伸, 鈴木絢子, 土居秀平, 柏木伸夫, 村上卓道, 松本逸平, 竹山宜典
    第63回中部・第64回関西IVR合同研究会, 2018年02月, 日本語, 長久手, 国内会議
    口頭発表（一般）

  • 教育講演「肝臓の画像診断とカテーテル治療」
    村上卓道
    近畿薬剤師合同学術大会2018, 2018年02月

  • 治療法の選択に影響を与える肝画像診断の進歩
    村上卓道
    第42回日本肝臓学会西部会, 2017年12月, 日本語, 福岡, 国内会議
    シンポジウム・ワークショップパネル（指名）

  • Virtual Unenhanced Algorithms for Fast-Kilovolt Switching Dual-Energy CT: Comparison Between Dedicated and Non-dedicated Softwares for Assessment of Liver Fat Content
    Hyodo T, Yada N, Maenishi O, Sasaki K, Kono Y, Murakami T
    103th Radiological Society of North America, 2017年11月

  • Iodine Density Imaging using Dual-energy CT in Patients with Hepatocellular Carcinoma After Transcatheter Arterial Chemoembolization: Quantitative Assessment of Ethiodized Oil Retention for Predicting Tumor Recurrence
    Hyodo T, Yagyu Y, Kono Y, Murakami T
    103th Radiological Society of North America, 2017年11月

  • Quantitative Magnetic Resonance Parameters and Their Relationship to Liver Fibrosis and Necroinflammation
    Sakamoto T, Onoda M, Hyodo T, Tsurusaki M, Nishimatsu K, Murakami T
    103th Radiological Society of North America, 2017年11月

  • Dual-Energy CT for Noninvasive Staging of Liver Fibrosis: Accuracy of Iodine Density Measurements from Contrast-Enhanced Data
    Sofue K, Tsurusaki M, Hyodo T, Murakami T
    103th Radiological Society of North America, 2017年11月

  • 乳腺密度がマンモグラフィでの模擬病変試料検出率に及ぼす影響
    山室美佳, 浅井義行, 山田浩司, 尾崎吉明, 松本政雄, 村上卓道
    第27回日本乳癌検診学会学術総会, 2017年11月

  • 指導者講習
    村上卓道
    第317回日本医学放射線学会関西地方会, 2017年11月

  • 皮質病変を認めた非アルコール性ウェルニッケ脳症の一例
    鈴木絢子, 松木 充, 土居秀平, 沼本勲男, 小田晃義, 藤谷哲也, 兵頭朋子, 山田 穣, 任 誠雲, 甲斐田勇人, 柳生行伸, 柏木伸夫, 細川知紗, 小塚健倫, 鶴﨑正勝, 今岡いずみ, 細野 眞, 石井一成, 村上卓道
    第317回日本医学放射線学会関西地方会, 2017年11月

  • 後腹膜発生動静脈奇形の一例
    土居秀平, 松木 充, 鈴木絢子, 沼本勲男, 小田晃義, 藤谷哲也, 兵頭朋子, 山田 穣, 任 誠雲, 甲斐田勇人, 柳生行伸, 柏木伸夫, 細川知紗, 小塚健倫, 鶴﨑正勝, 今岡いずみ, 細野 眞, 石井一成, 村上卓道
    第317回日本医学放射線学会関西地方会, 2017年11月

  • Prognostic assessment of 18F-FDG uptake using dual point imaging and partial volume correction in resected non-small cell lung cancer patients
    Kaida H, Azumi K, Kawahara A, Takamori S, Kage M, Fujimoto K, Axel Rominger, Ishii K, Murakami T, Ishibashi M
    European Association of Nuclear Medicine(EANM) 2017, 2017年10月

  • Volumetric parameterを用いた食道癌切除患者の予後因子の検討
    甲斐田勇人, 石井一成, 細川知紗, 柳生行伸, 任 誠雲, 兵頭朋子, 山田 穣, 細野 眞, 村上卓道, 安田卓司
    第57回日本核医学会学術総会, 2017年10月

  • 肝癌の最新画像診断と治療への応用
    村上卓道
    肝臓がんの画像診断と治療の最前線, 2017年09月

  • 指導者講習2
    村上卓道
    第53回日本医学放射線学会秋季臨床大会, 2017年09月

  • Advanced CT and MR Imaging for Improving Diagnosis and Treatment Quality
    Murakami T
    7th International Symposium in Computational Medical and Health Technology, 2017年09月

  • SAMIの紹介と肝画像診断の進歩
    村上卓道
    SAMI2017, 2017年07月

  • Dual-Energy CTから得られたヨード密度画像を用いた肝線維化の評価
    祖父江慶太郎, 鶴﨑正勝, 兵頭朋子, 佐々木公祐, 矢田典久, 工藤正俊, 杉村和朗, 村上卓道
    SAMI2017, 2017年07月

  • 新専⾨医制度の解説
    村上卓道
    JCRミッドサマーセミナー2017, 2017年07月

  • FDG-PET/CTで集積を認めた異所性甲状腺癌の一例
    甲斐田勇人, 石井一成, 細川知紗, 任 雲誠, 細野 眞, 村上卓道, 花岡宏平, 乾 浩己
    第50回日本核医学会近畿地方会, 2017年07月

  • 肝癌診療ガイドライン第4版公聴会：エビデンスとコンセンサス：第4版改訂のコンセプト
    村上卓道
    第53回日本肝癌研究会, 2017年07月

  • 十二指腸ブルンネル腺過誤腫の1例
    小田晃義, 松木 充, 沼本勲男, 福井秀行, 任 誠雲, 兵頭朋子, 柳生行伸, 鶴﨑正勝, 今岡いずみ, 石井一成, 村上卓道
    第31回日本腹部放射線学会, 2017年06月

  • TAFRO症候群の1例
    鈴木絢子, 沼本勲男, 松木 充, 小田晃義, 山田 穣, 兵頭朋子, 任 誠雲, 甲斐田勇人, 柳生行伸, 細川知紗, 小塚健倫, 柏木伸夫, 鶴﨑正勝, 今岡いずみ, 石井一成, 榎木英介, 村上卓道
    第31回日本腹部放射線学会, 2017年06月

  • 肝細胞癌のIVR治療～HCV・HBVにおいて～
    村上卓道
    第2回東京・神奈川肝疾患研究会, 2017年06月

  • Prognostic impact of 18F-FDG PET parameters and molecular markers expression in resected non-small cell lung cancer patients
    Kaida H, Azuma K, Kwahara A, Sadashima E, Hattori S, Akiba J, Rominger A, Rakamori S, Fujimoto K, Hosono M, Ishii K, Murakami R, Ishibashi M
    SNMMI 2017 Annual Meeting, 2017年06月

  • 当院におけるIVR穿刺技術教育の現状や課題
    鶴﨑正勝, 土居秀平, 鈴木絢子, 沼本勲男, 小田晃義, 柳生行伸, 柏木伸夫, 村上卓道
    第63回関西INTERVENTIONAL RADIOLOGY研究会, 2017年06月

  • 肝臓の画像診断 EOB-MRIによる肝細胞癌診断：ガイドラインにおける位置づけとそのエビデンス
    村上卓道
    平成29年度日本肝臓学会教育講演会, 2017年06月

  • Gd-EOB-DTPA-MRIによる肝細胞癌診断overview
    村上卓道
    南大阪肝癌診療セミナー－診断から治療まで－, 2017年06月

  • 腎細胞癌術前にNBCAにて腎動脈塞栓術を行った3例の病理学的検討
    沼本勲男, 鶴﨑正勝, 小田晃義, 任 誠雲, 柳生行伸, 柏木伸夫, 筑後孝章, 村上卓道
    第46回日本IVR学会総会, 2017年05月

  • 無水エタノールを用いた同側穿刺法による術前門脈塞栓術～「シース注入法」の有用性の検討～
    小田晃義, 鶴﨑正勝, 沼本勲男, 任 誠雲, 柳生行伸, 柏木伸夫, 中村友則, 竹山宜典, 村上卓道
    第46回日本IVR学会総会, 2017年05月

  • Estimation of Lobar Liver Function using Gadoxetic Acid-Enhanced MR Imaging: Comparison with 99mTc-GSA SPECT Imaging
    Sofue K, Tsurusaki M, Murakami T, Kitajima K, Yamaguchi M, Sugimoto K, Tanaka U, Takahashi S, Sugimura K
    26th International Society for Magnetic Resonance in Medicine, 2017年04月

  • Japan perspectives
    Murakami T
    The 6th Asian Congress of Abdominal Radiology, 2017年04月

  • 食道癌切除患者におけるFDG集積の予後検討
    甲斐田勇人, 石井一成, 細川知紗, 柳生行伸, 任 誠雲, 兵頭朋子, 山田 穣, 細野 眞, 安田卓司, 村上卓道
    第76回日本医学放射線学会総会, 2017年04月

  • 画像診断アルゴリズムと臨床的対応
    村上卓道
    第76回日本医学放射線学会総会, 2017年04月

  • 肝動脈塞栓術後の肝細胞癌局所再発予測：ヨード密度画像によるリピオドール定量
    兵頭朋子, 柳生行伸, 沼本勲男, 鶴﨑正勝, 任 誠雲, 上嶋一臣, 工藤正俊, 村上卓道
    第76回日本医学放射線学会総会, 2017年04月

  • 指導者講習
    村上卓道
    第76回日本医学放射線学会総会, 2017年04月

  • Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma:correlation with histological grading and portal blood flow
    Murakami T
    European Congress of Radiology 2017, 2017年03月

  • MRスペクトロスコピーによる生体ファントム脂肪定量
    兵頭朋子, 河野雄輝, 村上卓道
    第36回日本画像医学会, 2017年02月

  • 転移性耳下腺腫瘍のCT MRI所見
    柏木伸夫, 任 誠雲, 甲斐田勇人, 柳生行伸, 小塚建倫, 細川知紗, 松木 充, 鶴﨑正勝, 今岡いずみ, 細野 眞, 石井一成, 村上卓道
    第315回日本医学放射線学会関西地方会, 2017年02月

  • 直接穿刺による硬化療法を施行した腹壁静脈瘤の2例
    沼本勲男, 鶴﨑正勝, 小田晃義, 日高正二朗, 柳生行伸, 柏木伸夫, 村上卓道
    第62回関西Interventional Radiology研究会, 2017年02月

  • 肝胆膵：治療に役立つ肝胆膵画像診断：Development of Liver imaging for Diagnosis and Treatment of HCC
    村上卓道
    第30回 JCRミッドウィンターセミナー, 2017年01月

  • Algorithm for reference region delineation for amyloid imaging using pattern recognition scheme and kinetics of administered Aβ probe－considering the number of clusters－
    Yamada T, Kimura Y, Nagaoka T, Hosokawa C, Murakami T, Ishii K
    Human Amyloid Imaging Conference 2017, 2017年01月

  • Noise reduction algorithm for amyloid imaging without loss of image resolution
    Kimura Y, Fujii K, Yamada T, Hosokawa C, Sakata M, Murakami T, Ishii K
    Human Amyloid Imaging Conference 2017, 2017年01月

  • Gd-EOB-DTPA-MRIによる肝細胞癌診断overview
    村上卓道
    平成28年度奈良県MR Conference特別講演会, 2016年12月

  • Therapy Evaluation of Hepatocellular Carcinoma after Radio-frequency Ablation and Stereotactic Body Radiotherapy by CT, MR and US: Updated Interpretation
    Okada M, Numata K, Takeda A, Tanaka K, Murakami T, Murayama S
    102th Radiological Society of North America, 2016年11月

  • Usefulness of Double Frequency MR Elastography for Assessment of the Necroinflammation on Liver Stiffness Measurements
    Onoda T, Hyodo T, Murakami T, Tsurusaki M, Sakamoto T, Miyati T
    102th Radiological Society of North America, 2016年11月

  • 認知症患者における線条体アミロイド沈着の検討
    細川知紗, 石井一成, Sauerbeck J, Scheiwein F, 甲斐田勇人, 兵頭朋子, 山田 穣, 細野 眞, 花岡宏平, 村上卓道
    第56回日本核医学会学術総会, 2016年11月

  • 非小細胞肺癌のFDG集積とGlut-1, pStat1, pStat3での予後因子の検討
    甲斐田勇人, 東 公一, 河原明彦, 服部 聡, 藤本公則, 高森信三, 藤本公則, 高森信三, 石井一成, 村上卓道, 石橋正敏
    第56回日本核医学会学術総会, 2016年11月

  • 骨盤鬱滞症候群に対し、卵巣静脈塞栓術が奏功した1例
    小田晃義, 鶴﨑正勝, 柳生行伸, 沼本勲男, 日高正二朗, 任 誠雲, 柏木伸夫, 松木 充, 村上卓道
    第23回兵庫県IVR懇話会, 2016年10月

  • EOB-MRIの最適撮像法－GALIREO study（国内45施設における多施設試験）の結果を含めて－
    村上卓道
    第44回日本磁気共鳴医学会大会, 2016年09月

  • 広範な骨盤内浸潤を伴った子宮内膜症の一例
    小田晃義, 松木 充, 今岡いずみ, 沼本勲男, 福井秀行, 日高正二朗, 兵頭朋子, 小谷泰史, 任 誠雲, 柳生行伸, 柏木伸夫, 小塚健倫, 鶴﨑正勝, 万代昌紀, 村上卓道
    JSAWI2016, 2016年09月

  • FDG-PET/CTを契機に発見された再発性多発軟骨炎の一例
    甲斐田勇人, 石井一成, 細川知紗, 細野 眞, 村上卓道
    PETサマーセミナーin熊本, 2016年08月

  • 画像診断
    村上卓道
    平成28年度日本肝臓学会教育講演会, 2016年08月

  • 新しい専門医制度について
    村上卓道
    JCRミッドサマーセミナー2016, 2016年07月

  • 11C-PiB PET陽性認知症の線条体集積の有無の検討
    細川知紗, 石井一成, Julia Sauerbeck, Franziska Scheiwein, 甲斐田勇人, 兵頭朋子, 山田 穣, 細野 眞, 花岡宏平, 村上卓道
    第49回日本核医学会近畿地方会, 2016年07月

  • EOB-MRI肝細胞相で低信号を示す非多血性結節の多血化
    村上卓道
    第52回日本肝癌研究会, 2016年07月

  • 体幹部コイル塞栓術におけるPODTM(Penumbra Occlusion Device)の初期経験
    小田晃義, 鶴﨑正勝, 柳生行伸, 沼本勲男, 日高正二朗, 柏木伸夫, 松木 充, 村上卓道
    第61回関西Interventional Radiology研究会, 2016年06月

  • 十二指腸リンパ節瘻を合併した膵結核の1例
    渡口真史, 松木 充, 沼本勲男, 福井秀行, 若林雄一, 山川美帆, 任 誠雲, 兵頭朋子, 柳生行伸, 鶴崎正勝, 今岡いずみ, 石井一成, 田中利絵, 今井 元, 石川 原, 竹山宜典, 前西 修, 村上卓道
    第30回日本腹部放射線学会, 2016年06月

  • 副腎結核の1例
    沼本勲男, 松木 充, 渡口真史, 福井秀行, 若林雄一, 山川美帆, 任 誠雲, 兵頭朋子, 柳生行伸, 鶴﨑正勝, 今岡いずみ, 石井一成, 村上卓道
    第30回日本腹部放射線学会, 2016年06月

  • Cerebral glucose metabolic reduction patterns of PiB accumulation positive and negative cognitive disordered subjects
    Hosokawa C, Ishii K, Kimura Y, Kaida Y, Wakabayashi Y, Hyodo T, Hosono M, Murakami T
    SNMMI 2016 Annual Meeting, 2016年06月

  • 孤立性腹部内臓動脈解離のCT所見
    福井秀行, 松木 充, 小田晃義, 沼本勲男, 日高正二朗, 任 誠雲, 兵頭朋子, 柳生行伸, 小塚健倫, 鶴﨑正勝, 今岡いずみ, 石井一成, 村上卓道
    第313回公益社団法人日本医学放射線学会関西地方会, 2016年06月

  • New development of MDCT liver imaging
    Murakami T
    Japanese-German Bi-Annual Meeting 2016 Preliminary schedule of the scientific meeting, 2016年06月

  • Increased Pittsburgh Compound B accumulation in the white matter of Alzheimer brain
    Wakabayashi Y, Ishii K, Hosokawa C, Hyodo T, Kaida H, Yamada M, Yagyu Y, Tsurusaki M, Sugimura K, Murakamai T
    日本分子イメージング学会 第11回総会・学術集会, 2016年05月

  • HCC に対するDEB－TACE 時に発生したVascular lake の検討
    沼本勲男, 鶴﨑正勝, 渡口真史, 日高正二朗, 山川美帆, 任 誠雲, 柳生行伸, 村上卓道, 田北雅弘, 萩原 智, 南 康範, 上嶋一臣, 西田直生志, 工藤正俊, 朝戸信行
    第45回日本IVR学会総会, 2016年05月

  • DP-CAR（腹腔動脈合併尾側膵切除術）前にAmplatzer Vascular Plug を用いて総肝動脈塞栓を行った４症例
    渡口真史, 鶴﨑正勝, 沼本勲男, 日高正二朗, 朝戸信行, 山川美帆, 任 誠雲, 柳生行伸, 松木 充, 竹山宜典, 村上卓道
    第45回日本IVR学会総会, 2016年05月

  • 膵炎や膵手術に伴う仮性動脈瘤に対するカテーテル的塞栓術
    沼本勲男, 鶴﨑正勝, 渡口真史, 山川美帆, 朝戸信行, 任 誠雲, 柳生行伸, 村上卓道
    第75回日本医学放射線学会総会, 2016年04月
    ポスター発表

  • 転移性耳下腺腫瘍のCT,MRI所見
    柏木伸夫, 日高正二朗, 福井秀行, 柳生行伸, 中西克之, 小塚健倫, 石井一成, 沼本勲男, 筑後孝章, 村上卓道
    第75回日本医学放射線学会総会, 2016年04月
    口頭発表（一般）

  • Dual-energy CTを用いた肝ダイナミックCTの造影剤量低減
    兵頭朋子, 熊野正士, 中西順子, 矢田典久, 鶴﨑正勝, 工藤正俊, 村上卓道
    第75回日本医学放射線学会総会, 2016年04月
    ポスター発表

  • 最新の肝癌画像診断
    村上卓道
    第75回日本医学放射線学会総会, 2016年04月
    シンポジウム・ワークショップパネル（指名）

  • 認知障害の11C PiB PETでの線条体集積と脳糖代謝の相関
    細川知紗, 石井一成, 木村雄一, 甲斐田勇人, 若林雄一, 兵頭朋子, 山田 穣, 小塚健倫, 細野 眞, 村上卓道
    第75回日本医学放射線学会総会, 2016年04月, 国際会議
    口頭発表（一般）

  • Advanced liver imaging: Improved treatment decision
    Murakami T
    European Congress of Radiology 2016, 2016年03月

  • 上顎洞術後変化としての眼窩下管拡大
    福井秀行, 柏木伸夫, 任 誠雲, 甲斐田勇人, 柳生行伸, 小塚健倫, 細川知紗, 熊野正士, 鶴﨑正勝, 松木 充, 今岡いずみ, 細野 眞, 石井一成, 村上卓道
    第35回日本画像医学会, 2016年02月

  • MRスペクトロスコピーによる生体ファントム脂肪定量
    兵頭朋子, 鶴﨑正勝, 村上卓道
    第35回日本画像医学会, 2016年02月

  • CT and MR Imaging for Diagnosis and Treatment of HCC
    Murakami T
    25th Conference of the Asian Pacific Association for the Study of the Liver, 2016年02月

  • 神経核内封入体病の1例
    沼本勲男, 松木 充, 福井秀行, 若林雄一, 日高正二朗, 渡口真史, 藤谷哲也, 山川美帆, 兵頭朋子, 山田 穣, 任 誠雲, 甲斐田勇人, 柳生行伸, 柏木伸夫, 細川知紗, 小塚健倫, 鶴﨑正勝, 今岡いずみ, 細野 眞, 石井一成, 村上卓道
    第312回日本医学放射線学会関西地方会, 2016年02月

  • USガイド鎖骨下静脈アプローチによる中心静脈ポート留置に伴った胸肩峰動脈分枝損傷に対し動脈塞栓術を施行した1例
    日高正二朗, 鶴﨑正勝, 沼本勲男, 渡口真史, 山川美帆, 任 誠雲, 柳生行伸, 村上卓道
    第59回中部IVR研究会・第60回関西INTERVENTIONAL RADIOLOGY研究会, 2016年02月

  • DCビーズを用いたDEB-TACE後に腫瘍破裂を来した当院での1例
    沼本勲男, 鶴﨑正勝, 日高正二朗, 渡口真史, 山川美帆, 任 誠雲, 柳生行伸, 松木 充, 村上卓道, 萩原 智, 工藤正俊
    第59回中部IVR研究会・第60回関西INTERVENTIONAL RADIOLOGY研究会, 2016年02月

  • DP-CAR（腹腔動脈合併尾側膵切除術）術前にAmplatzer Vascular Plugを用いて総肝動脈塞栓を行った3症例
    渡口真史, 鶴﨑正勝, 沼本勲男, 山川美帆, 任 誠雲, 柳生行伸, 松木 充, 村上卓道, 竹山宜典
    第59回中部IVR研究会・第60回関西INTERVENTIONAL RADIOLOGY研究会, 2016年02月

  • 最新の肝画像診断と治療への応用
    村上卓道
    第12回神戸肝臓病研究会, 2016年02月

  • 肝線維化診断におけるMR elastographyの有用性の検討：生検検体を用いたTransient elastographyとの比較
    渡口真史, 鶴﨑正勝, 兵頭朋子, 沼本勲男, 熊野正士, 松木 充, 村上卓道, 矢田典久, 工藤正俊
    第22回肝血流動態・機能イメージ研究会, 2016年02月

  • Bizarre parosteal osteochondromatous proliferation of the sternum
    Fukui H, Kashiwagi N, Enoki E, Nakajima Y, Numoto I, Wakabayashi Y, Toguchi M, Asato N, Yamakawa M, Im S, Hyodo T, Yagyu Y, Kumano M, Tsurusaki M, Imaoka I, Matsuki M, Ishii K, Murakami T
    第27回日本骨軟部放射線研究会, 2016年01月

  • Iodine Load Reduction at Hepatic Dynamic CT using Virtual Monochromatic Imaging with a Fast kVp Switching Dual-Energy CT
    Hyodo T, Kumano M, Nakanishi J, Uemura M, Kudo M, Murakami T, Toguchi M, Fukui H, Yada N, Ishii K, Mochizuki T
    101th Radiological Society of North America- Scientific Poster, 2015年11月

  • GDAコイル法による肝動注リザーバー留置後に胆道出血をきたした一例
    沼本勲男, 鶴﨑正勝, 渡口真史, 日高正二朗, 山川美帆, 任 誠雲, 柳生行伸, 松木 充, 村上卓道
    第40回リザーバー研究会, 2015年11月, 国内会議

  • アミロイドイメージングにおける組織放射能時間曲線に対するパターン認識による参照領域設定アルゴリズム
    木村裕一, 山田誉大, 永岡 隆, 細川知紗, 石井一成, 村上卓道
    第55回日本核医学会学術総会, 2015年11月

  • PiB陰性例の18F-FDG PETによる脳代謝分布の検討
    細川知紗, 石井一成, 若林雄一, 兵頭朋子, 花田一志, 甲斐田隼人, 細野 眞, 木村裕一, 村上卓道
    第55回日本核医学会学術総会, 2015年11月

  • 膵癌のFDG集積とmTOR関連マーカーとの相関性に関する分子病理学的検討
    甲斐田勇人, 東 公一, 河原明彦, 安永昌史, 服部 聡, 倉田精二, 廣瀬靖光, 鹿毛政義, 石井一成, 村上卓道, 石橋正敏
    第55回日本核医学会学術総会, 2015年11月

  • 上顎洞術後変化としての眼窩下管拡大
    福井秀行, 柏木伸夫, 任 誠雲, 甲斐田勇人, 柳生行伸, 小塚健倫, 細川知紗, 熊野正士, 鶴﨑正勝, 松木 充, 今岡いずみ, 石井一成, 細野 眞, 村上卓道
    第311回公益社団法人日本医学放射線学会関西地方会, 2015年10月, 国内会議
    口頭発表（一般）

  • ガイドラインからみた肝臓画像診断の進め方
    村上 卓道
    第50回兵庫県放射線医学総会, 2015年10月

  • Therapy planning and dose prescription in radioiodine-131 therapy for hyperthyroidism using radioiodine-123 SPECT/CT imaging
    Hanaoka K, Hosono M, Otsuka M, Asai Y, Okumura M, Ishii K, Murakami T
    EANM’15-Annual Congress of the European Association of Nuclear Medicine, 2015年10月

  • Introducing the glucose metabolism to amyloid deposition ratio image
    Ishii K, Takahashi R, Wakabayashi Y, Hosokawa C, Kaida H, Murakami T
    EANM’15-Annual Congress of the European Association of Nuclear Medicine, 2015年10月

  • The correlation between 18F-FDG uptake and Glut-1, Stat-1 and Stat-3 in non-small cell lung cancer patients
    Kaida H, Azuma K, Kawahara A, Hattori S, Takamori S, Sadashima E, Fujimoto K, Kage M, Kurata S, Hirose Y, Ishii K, Murakami T, Ishibashi M
    EANM’15-Annual Congress of the European Association of Nuclear Medicine, 2015年10月

  • 腹部画像診断の進歩
    村上 卓道
    日本消化器病学会近畿支部第49回教育講演, 2015年09月

  • アルツハイマー病診断におけるADCmapの臨床有用性の検討
    高橋洋人, 石井一成, 渡邉嘉之, 田中 壽, 有澤亜津子, 松尾千聡, 村上卓道
    第43回日本核磁気共鳴医学会大会, 2015年09月

  • ガイドラインから見た肝癌画像診断の進め方
    村上卓道
    2015JCRミッドサマーセミナー, 2015年07月, 国内会議

  • PET検診で発見されたFDG集積を伴う解離性大動脈瘤の一例
    甲斐田勇人, 石井一成, 村上卓道, 田原宣広, 本多亮博, 福本義弘, 石橋正敏
    第48回日本核医学会近畿地方会, 2015年07月, 国内会議

  • 最新の肝画像診断と治療への応用
    村上卓道
    岩手臨床画像セミナー, 2015年07月, 国内会議

  • Multimodality fusion imaging for HCC Toward Improved Treatment Decisions
    村上卓道
    第11回宮崎消化器内科セミナー, 2015年07月, 国内会議

  • New Insigths in Imaging:New CT Technology for the Liver Imaging
    Murakami T
    The 6th Asia-Pacific Primary Liver Cancer Expert Meeting, 2015年07月, 国際会議

  • GDAコイル法による肝動注リザーバー留置後に胆道出血をきたした一例
    日高正二朗, 鶴﨑正勝, 柳生行伸, 沼本勲男, 渡口真史, 山川美帆, 任 誠雲, 松木 充, 村上卓道
    第59回関西INTERVENTIONAL RADIOLOGY研究会, 2015年06月, 国内会議

  • 上腸間膜静脈血栓症による急性腸管虚血に対しTIPSを施行した一例
    沼本勲男, 鶴﨑正勝, 柳生行伸, 渡口真史, 山川美帆, 任 誠雲, 松木 充, 村上卓道, 萩原 智, 工藤 正俊, 吉藤竹仁, 船内正憲
    第59回関西INTERVENTIONAL RADIOLOGY研究会, 2015年06月, 国内会議

  • 卵巣提索のうっ滞所見が明瞭であった卵巣線維腫茎捻転の1例
    福井秀行, 松木 充, 沼本勲男, 若林雄一, 渡口真史, 朝戸信行, 山川美帆, 任 誠雲, 兵頭朋子, 柳生行伸, 熊野正士, 鶴﨑正勝, 今岡いずみ, 足利竜一朗, 石井一成, 村上卓道
    第29回日本腹部放射線学会, 2015年06月, 国内会議

  • 肝細胞腺腫から移行したと思われる高分化型肝細胞癌の1例
    渡口真史, 松木 充, 兵頭朋子, 柳生行伸, 今岡いずみ, 鶴﨑正勝, 足利竜一朗, 村上卓道, 任 誠雲, 山川美帆, 朝戸信行, 若林雄一, 福井秀行, 沼本勲男, 中居卓也, 石川 原, 竹山宜典, 榎木英介
    第29回日本腹部放射線学会, 2015年06月, 国内会議

  • 腎周囲腔発生sclerosing variant of PEComaの1例
    山川美帆, 松木 充, 沼本勲男, 福井秀行, 若林雄一, 渡口真史, 朝戸信行, 千葉輝明, 任 誠雲, 兵頭朋子, 柳生行伸, 細川知紗, 熊野正士, 鶴﨑正勝, 今岡いずみ, 足利竜一朗, 石井一成, 筑後孝章, 植村天受, 村上卓道
    第29回日本腹部放射線学会, 2015年06月, 国内会議

  • 膀胱子宮内膜症の経過を追った2例
    沼本勲男, 今岡いずみ, 若林雄一, 藤谷哲也, 山川美帆, 兵頭朋子, 甲斐田勇人, 柳生行伸, 熊野正士, 鶴﨑正勝, 松木 充, 石井一成, 村上卓道
    第310回日本医学放射線学会関西地方会, 2015年06月, 国内会議

  • ANCA関連後縦隔線維症の一例
    日高正二朗, 小塚健倫, 福井秀行, 渡口真史, 山田 穣, 任 誠雲, 柏木伸夫, 細川知紗, 鶴﨑正勝, 今岡いずみ, 松木 充, 石井一成, 村上卓道
    第310回日本医学放射線学会関西地方会, 2015年06月, 国内会議

  • Increased Pittsburgh Compound B accumulation in the regional white matters of Alzheimer brain
    Wakabayashi Y, Ishii K, Hosokawa C, Hyodo T, Kozuka T, Murakami T, Sugimura K
    2015 Annual Meeting of Society of Nuclear Medicine and Molecular Imaging, 2015年06月, 国際会議

  • The correlation of dual phase 18F-FDG PET/CT to immunohistochemical prognostic factors in breast cancer patients
    Kaida H, Toh U, Kawahara A, Kurata S, Hirose Y, Kage M, Ishii K, Murakamai T, Ishibashi M
    2015 Annual Meeting of Society of Nuclear Medicine and Molecular Imaging, 2015年06月, 国際会議

  • Evaluation of the outcome after occlusive complication of implantable port-catheter system for hepatic arterial infusion chemotherapy
    Yamakawa M, Tsurusaki M, Numoto I, Toguchi M, Asato N, Im S, Yagyu Y, Kashiwagi N, Matsuki M, Murakami T
    JSIR,ISIR&APCIO, 2015年05月, 国際会議

  • Transcatheter embolization for bleeding visceral artery pseudoaneurysm in the patients with pancreatitis or pancreatic surgery
    Numoto I, Tsurusaki M, Toguchi M, Yamakawa M, Asato N, Im S, Yagyu Y, Murakami T
    JSIR,ISIR&APCIO, 2015年05月, 国際会議

  • 肝腫瘍の画像診断：鑑別のポイント
    村上卓道
    第51回日本肝臓学会総会, 2015年05月, 国内会議

  • 肝画像診断の進歩
    村上卓道
    第51回日本肝臓学会総会, 2015年05月, 国内会議

  • 肝細胞癌に対するRFA後の再発診断：EOB造影MRIと造影CTの前向き比較試験
    今井康陽, 片山和宏, 村上卓道
    第51回日本肝臓学会総会, 2015年05月, 国内会議

  • 早期肝細胞癌の画像所見と治療戦略
    今井康陽, 小来田幸世, 村上卓道
    第51回日本肝臓学会総会, 2015年05月, 国内会議

  • NAFLDにおけるDual energy CTを用いた肝脂肪変性定量評価の有用
    岡部純弥, 澤井良之, 福田和人, 井倉 技, 小来田幸世, 今井康陽, 磯谷圭介, 米澤 稔, 藤田典彦, 兵頭朋子, 辻川華子, 阿部時也, 橋口明典, 坂元亨宇, 村上卓道
    第51回日本肝臓学会総会, 2015年05月, 国内会議

  • PIB-PETによるAD脳の白質でのアミロイド集積亢進について
    若林雄一, 石井一成, 細川知紗, 兵頭朋子, 山田 穣, 柳生行伸, 鶴﨑正勝, 小塚健倫, 杉村和朗, 村上卓道
    第74回日本医学放射線学会総会, 2015年04月, 国内会議

  • Iodine Load Reduction at Hepatic Dynamic CT: Usefulness of the Virtual Monochromatic Imaging using a Fast kVp Switching Dual-Energy CT
    Hyodo T, Nakanishi J, Asato N, Tsurusaki M, Matsuki M, Uemura M, Kudo M, Murakami T
    The 27th European Congress of Radiology - Scientific Exhibit, 2015年03月, 国際会議

  • Recent progress of multimodality imaging for HCC
    Murakami T
    22th International Seoul Radiology Symposium, 2015年02月, 国際会議

  • Dual energy CTを用いた肝脂肪変性定量評価の有用性～肝生検標本を用いた脂肪変性定量との比較
    岡部純弥, 澤井良之, 小来田幸世, 井倉 技, 福田和人, 磯谷圭介, 藤田典彦, 今井康陽, 辻井華子, 阿部時也, 橋口明典, 坂元亨宇, 村上卓道
    第21回肝血流動態・機能イメージ研究会, 2015年02月, 国内会議

  • 当院における肝細胞癌に対するディーシービーズⓇを用いたDEB-TACEの治療成績
    渡口真史, 鶴﨑正勝, 柳生行伸, 沼本勲男, 朝戸信行, 山川美帆, 任 誠雲, 松木 充, 村上卓道, 井上達夫, 萩原 智, 南 康範, 上嶋一臣, 工藤正俊
    第21回肝血流動態・機能イメージ研究会, 2015年02月, 国内会議

  • plain cone-beam CTによる肝動脈塞栓術の早期治療効果予測（第2報）
    南 康範, 村上卓道, 工藤正俊
    第21回肝血流動態・機能イメージ研究会, 2015年02月, 国内会議

  • Imaging of Uncommon Site Metastases from Breast Cancer: A Pictorial Review
    Toguchi M, Matsuki M, Hyodo T, Murakami T, Imaoka I, ishii K, Tsurusaki M, Kumano S
    100th Radiological Society of North America- Education Exhibit, 2014年11月, 国際会議

  • Noninvasive Assessment of Liver Fibrosis with Iodine Quantification Using Dual-energy CT in Chronic Liver Disease
    Asato N, Tsurusaki M, Hyodo T, Matsuki M, Ishii K, Murakami T
    100th Radiological Society of North America- Scientific Poster, 2014年11月, 国際会議

  • A Multi-Material Decomposition Algorithm for Liver Fat Quantification in Dual-Energy CT: Reproducibility of the Method, and Comparison with MR Spectroscopy
    Hyodo T, Yada N, Maenishi O, Lamb P, Sasaki K, Murakami T, Tsurusaki M, Ishii K, Matsuki M, Kumano M, Mochizuki T
    100th Radiological Society of North America- Scientific Paper, 2014年11月, 国際会議

  • Diagnosis of Dementia with Lewy Bodies (DLB) with Neuroimaging Techniques
    Ishii K, Hosokawa C, Hyodo T, Takahashi H, Kashiwagi N, Murakami T, Matsuki M, Ashikaga R
    100th Radiological Society of North America- Education Exhibit, 2014年11月, 国際会議

  • CT Imaging of Various Gastric Lesions: A Pictorial Review
    Matsuki M, Hyodo T, Kumano S, Tsurusaki M, Ishii K, Murakami T
    100th Radiological Society of North America- Education Exhibit., 2014年11月, 国際会議

  • Non-Surgical Management for Hepatocellular Carcinoma with Vascular Tumor Thrombus
    Tsurusaki M, Murakami T, Asato N, Yagyu Y, Kumano S, Matsuki M
    100th Radiological Society of North America- Education Exhibit, 2014年11月, 国際会議

  • Liver Dysfunction Imaging on MRI: Are You Working on Quantifying Fat, Fibrosis and Iron of the Liver?
    Okada M, Wakayama T, Koga T, Tsuchiya N, Murakami T, Murayama S
    100th Radiological Society of North America- Education Exhibit, 2014年11月, 国際会議

  • Advanced Liver Imaging
    村上卓道
    第1回医療と画像診断フォーラム, 2014年11月, 国内会議

  • Multimodality fusion imaging for HCC：Toward Improved Treatment Decisions
    村上卓道
    相模原肝細胞癌セミナー, 2014年11月, 国内会議

  • Gd-EOB-DTPA-MRIによる肝細胞癌診断overview
    村上卓道
    第3回鹿児島EOBセミナー, 2014年11月, 国内会議

  • 軽症アルツハイマー症の18F- FDG PETと11C-PiB PET検査の経時的画像変化の検討
    細川知紗, 石井一成, 兵頭朋子, 坂口健太, 宇佐美公男, 若林雄一, 鶴﨑正勝, 松木 充, 細野 眞, 村上卓道
    第54回日本核医学会学術総会, 2014年11月, 国内会議

  • 下肢静脈疾患におけるMR venographyの有用性及び造影CTとのすみわけについて
    朝戸信行, 保田知生, 柳生行伸, 今岡いずみ, 鶴﨑正勝, 村上卓道
    第55回日本脈管学会総会, 2014年10月, 国内会議

  • 当院における胃粘膜下腫瘍に対する18F-FDG PET 検査
    沼本勲男, 松木 充, 福井秀行, 若林雄一, 渡口真史, 千葉輝明, 山田 穣, 柏木伸夫, 細川知紗, 小塚健倫, 細野 眞, 石井一成, 村上 卓道
    第308回日本医学放射線学会関西地方会, 2014年10月, 国内会議

  • 当院における内視鏡不完全症例に対するCT colonography の活用
    松木 充, 朝戸信行, 山川美帆, 藤谷哲也, 任 誠雲, 兵頭朋子, 柳生行伸, 鶴﨑正勝, 熊野正士, 今岡いずみ, 足利竜一朗, 石井一成, 村上卓道
    第308回日本医学放射線学会関西地方会, 2014年10月, 国内会議

  • IgG4 関連疾患によると思われる冠動脈病変の一例
    千葉輝明, 松木 充, 今岡いずみ, 熊野正士, 小塚健倫, 柏木伸夫, 柳生行伸, 足利竜一朗, 鶴﨑正勝, 石井一成, 村上卓道, 平野 豊, 樋野尚一
    第308回日本医学放射線学会関西地方会, 2014年10月, 国内会議

  • Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition
    Ishii K, Hosokawa C, Hyodo T, Sakaguchi K, Usami K, Shimamoto K, Yamazoe Y, Hosono M, Hanada K, Ueda M, Saigo K, Murakami T
    EANM’14-Annual Congress of the European Association of Nuclear Medicine, 2014年10月, 国際会議

  • Dual energy CTを用いた肝脂肪変性定量評価の有用性～肝生検標本を用いた脂肪変性定量との比較
    岡部純弥, 澤井良之, 福田和人, 井倉 技, 小来田幸世, 今井康陽, 磯谷圭介, 辻井華子, 坂元亨宇, 村上卓道
    第9回肝癌治療シミュレーション研究会, 2014年09月, 国内会議

  • AOCR2014-AOSOR Conjoint Session：Advanced Liver Imaging
    Murakami T, Tsurusaki M, Hyodo T, Imai Y
    The 15th Asian Oceanian Congress of Radiology, 2014年09月, 国際会議

  • Investigation of 11C-PiB-equivocal PET Findings
    Hosokawa C, Ishii K, Hyodo T, Wakabayashi Y, Im S, Tsurusaki M, Imaoka I, Kozuka T, Matsuki M, Ashikaga R, Hosono M, Murakami T
    The 15th Asian Oceanian Congress of Radiology, 2014年09月, 国際会議

  • Hypervascular Focal Nodular Hyperplasia-like Nodules in Chronic Alcoholic Liver Disease Mimicking Hepatocellular Carcinoma
    Im S, Tsurusaki M, Hidaka S, Asato N, Hyodo T, Matsuki M, Ishii K, Murakami T
    The 15th Asian Oceanian Congress of Radiology, 2014年09月, 国際会議

  • 嗜銀顆粒性認知症と考えられた１例
    若林雄一, 石井一成, 河内 崇, 細川知紗, 山川美帆, 兵頭朋子, 任 誠雲, 鶴﨑正勝, 松木 充, 細野 眞, 北村 登, 村上卓道
    第47回日本核医学会近畿地方会, 2014年07月

  • Optimizing Imaging Diagnosis
    Murakami T
    Asia-Pacific Primary Liver Cancer Expert Meeting, 2014年07月, 国際会議

  • 無水エタノールを用いた経皮経肝門脈塞栓術後に著明な血小板減少を認めた一例
    朝戸信行, 柳生行伸, 鶴﨑正勝, 沼本勲男, 渡口真史, 山川美帆, 任 誠雲, 村上卓道
    第57回関西Interventional Radiology研究会, 2014年07月, 国内会議

  • TOF完全修復後遠隔期肺動脈弁置換術（PVR）の心機能評価
    千葉輝明, 濵田星紀, 上野高義, 金澤 達, 梁川雅弘, 本多 修, 村上卓道, 富山憲幸
    第79回日本心臓血管放射線研究会, 2014年07月, 国内会議

  • A case of multifocal nodular steatosis in the liver with chronic hepatitis C
    Hyodo T, Matsukubo Y, Matsuki M, Kitai S, Inoue T, Chikugo T, Sato T, Murakami T
    第28回日本腹部放射線学会, 2014年06月

  • A case of solid variant serous cystic neoplasm of the pancreas associated with von Hippel-Lindau disease
    Numoto I, Asato N, Matsuki M, Fukui H, Fujigai T, Chiba t, Im S, Hyodo T, Yamada M, Yagyu Y, Kashiwagi N, Hosokawa C, Kozuka T, Imaoka I, Tsurusaki M, Ashikaga R, Ishii K, Murakami T
    第28回日本腹部放射線学会, 2014年06月

  • Gd-EOB-DTPA-MRIによる肝細胞癌診断overview
    村上卓道
    EOB・プリモビストセミナー, 2014年06月, 国内会議

  • PET approaches for diagnosis of dementia in Japan
    Ishii K, Hosokawa C, Murakami T
    17th Workshops of Japanese-German Radiological Affiliation, 2014年06月, 国際会議

  • 肝特異性造影剤を用いた早期肝細胞癌の診断と治療戦略
    小来田幸世, 今井康陽, 澤井良之, 井倉 技, 福田和人, 関 康, 森本修邦, 中島 収, 坂元亨宇, 熊田 卓, 村上卓道
    第50回日本肝癌研究会, 2014年06月, 国内会議

  • Fusion imageを用いた経皮的局所治療のイノベーション
    井倉 技, 澤井良之, 小来田幸世, 福田和人, 村上卓道, 今井康陽
    第50回日本肝癌研究会, 2014年06月, 国内会議

  • Dual-energy CTを用いた肝脂肪定量
    兵頭朋子, 矢田典久, 前西 修, 工藤正幸, 朝戸信行, 柳生行伸, 鶴﨑正勝, 松木 充, 足利竜一朗, 石井一成, 工藤正俊, 村上卓道
    第50回日本肝癌研究会, 2014年06月, 国内会議

  • アルコール性肝障害に併発したFNH-like nodule、肝細胞癌の画像、病理学的所見の比較検討
    澤井良之, 鶴﨑正勝, 福田和人, 井倉 技, 小来田幸世, 大橋寛嗣, 大濱日出子, 津田和宏, 樋口和秀, 中島 収, 佐々木素子, 中沼安二, 北尾 梓, 松井 修, 村上卓道, 今井康陽
    第50回日本肝癌研究会, 2014年06月, 国内会議

  • 肝細胞癌診断アルゴリズムにおけるEOB-MRIの位置付け
    今井康陽, 村上卓道
    第50回日本肝癌研究会, 2014年06月, 国内会議

  • Tracking Navigation System of Cone-Beam CT Angiography（FlightPlan）支援TACEの有用性
    村上卓道
    第50回日本肝癌研究会, 2014年06月, 国内会議

  • Interventional radiologyにおける支援画像「FlightPlan」の有用性
    南 康範, 南 知宏, 千品寛和, 有住忠晃, 田北雅弘, 北井 聡, 矢田典久, 萩原 智, 井上達夫, 上嶋一臣, 西田直生志, 工藤正俊, 柳生行伸, 鶴﨑正勝, 村上卓道
    第50回日本肝癌研究会, 2014年06月, 国内会議

  • 肝疾患におけるIVRの進歩
    村上卓道
    第50回日本肝臓学会総会, 2014年05月, 国内会議

  • Dual energy CTを用いた肝脂肪変性定量評価の有用性～肝生検標本を用いた脂肪変性定量との比較
    倉橋知英, 澤井良之, 福田和人, 井倉 技, 小来田幸世, 今井康陽, 磯谷圭介, 米澤 稔, 藤田典彦, 兵頭朋子, 辻川華子, 阿部時也, 橋口明典, 坂本亨宇, 村上卓道
    第50回日本肝臓学会総会, 2014年05月, 国内会議

  • plain cone-beam CTによる肝動脈塞栓術の定量的治療効果予測
    南 康範, 村上卓道, 工藤正俊
    第50回日本肝臓学会総会, 2014年05月, 国内会議

  • Fusion image を用いた経皮的局所治療成績向上のための工夫-Extracted-overlay gunctionを用いたRFA治療支援と効果判定に関する検討-
    井倉 技, 今井康陽, 小来田幸世, 澤井良之, 福田和人, 磯谷圭介, 藤田典彦, 牧野祐紀, 村上卓道
    第50回日本肝臓学会総会, 2014年05月, 国内会議

  • EOB-MRIとSonazoid造影USによる早期肝細胞癌の診断と治療選択
    今井康陽, 村上卓道, 熊田 卓
    第100回日本消化器病学会総会, 2014年04月, 国内会議

  • plain cone-beam CTによる肝動脈塞栓術の定量的治療効果予測
    南 康範, 南 知宏, 有住忠晃, 田北雅弘, 北井 聡, 矢田典久, 井上達夫, 萩原 智, 上嶋一臣, 西田直生志, 工藤正俊, 柳生行伸, 村上卓道
    第100回日本消化器病学会総会, 2014年04月, 国内会議

  • Dual-energy CTを用いた肝脂肪定量アルゴリズムの臨床的有用性
    兵頭朋子, 矢田典久, 前西 修, 工藤正幸, 朝戸信行, 鶴﨑正勝, 松木 充, 石井一成, 工藤正俊, 村上卓道
    第73回日本医学放射線学会総会, 2014年04月, 国内会議

  • 多時相撮影ASL-MR潅流像を用いた脳血流評価によるアルツハイマー病診断
    高橋洋人, 石井一成, 柏木伸夫, 足利竜一朗, 松木 充, 村上卓道
    第73回日本医学放射線学会総会, 2014年04月, 国内会議

  • Dual energy CTを用いたdynamic CTによる肝線維化の評価
    朝戸信行, 鶴﨑正勝, 兵頭朋子, 松木 充, 工藤正幸, 石井一成, 村上卓道
    第73回日本医学放射線学会総会, 2014年04月, 国内会議

  • Conebeam CTを用いたIVR支援機能
    村上 卓道
    第73回日本医学放射線学会総会, 2014年04月, 国内会議

  • 11C-PIB PET陽性の集積分布パターンとFDG PETの対比
    細川知紗, 石井一成, 兵頭朋子, 山田 穣, 柏木伸夫, 鶴﨑正勝, 今岡いずみ, 松木 充, 細野 眞, 村上卓道
    第73回日本医学放射線学会総会, 2014年04月, 国内会議

  • Extracted-overlay functionを用いたRFA治療支援と効果判定に関する検討
    井倉 技, 村上 卓道, 小来田 幸世, 澤井 良之, 福田 和人, 今井 康陽
    第16回関西肝癌局所療法研究会, 2014年03月, 大阪, 国内会議

  • 当院におけるマイクロバルーン閉塞下肝動脈化学塞栓療法（B-TACE）導入後の検討
    田北雅弘, 千品寛和, 有住忠晃, 北井 聡, 井上達夫, 矢田典久, 荻原 智, 上嶋一臣, 西田直生志, 朝戸信行, 任 誠雲, 柳生行伸, 鶴﨑正勝, 村上卓道, 工藤正俊
    第16回関西肝癌局所療法研究会, 2014年03月, 国内会議

  • Extracted overlay functionを用いたRFA治療支援と効果判定に関する検討
    井倉 技, 村上 卓道, 牧野 祐紀, 小来田 幸世, 澤井 良之, 福田 和人, 今井 康陽
    第20回肝血流動態・機能イメージ研究会, 2014年02月, 大阪, 国内会議

  • Dual energy CTを用いたdynamicCTによる肝線維化の評価
    朝戸 信行, 村上 卓道, 鶴﨑 正勝, 兵頭 朋子, 福井 秀行, 任 誠雲, 栁生 行伸, 岡田 真広, 今岡 いずみ, 松木 充, 足利 竜一朗, 矢田 典久, 前西 修, 工藤 正俊, 工藤 正幸
    第20回肝血流動態・機能イメージ研究会, 2014年02月, 国内会議

  • plain cone-beam CTによる肝動脈塞栓術の定量的治療効果予測
    南 康範, 南 知宏, 有住忠晃, 田北雅弘, 北井 聡, 矢田典久, 井上達夫, 萩原 智, 上嶋一臣, 西田直生志, 工藤正俊, 柳生行伸, 村上卓道
    第20回肝血流動態・機能イメージ研究会, 2014年02月, 国内会議

  • EOB-MRIと造影超音波検査による乏血性結節の多血化因子の検討
    井上達夫, 兵頭朋子, 千品寛和, 有住忠晃, 田北雅弘, 北井 聡, 矢田典久, 萩原 智, 上嶋一臣, 西田直生志, 村上卓道, 工藤正俊
    第20回肝血流動態・機能イメージ研究会, 2014年02月, 国内会議

  • Treatment Planning for Gastric Cancer: The Role of CT Gastrography
    Kumano M, Murakami M, Tsuboyama T, Juri H, Yamamoto K, Narumi Y
    99th Radiological Society of North America, 2013年12月, chicago, 国際会議

  • Low Tube Voltage CT with Iterative Reconstruction for the Diagnosis of Hepatocellular Carcinoma? HCC?
    Okada M, Takahashi H, Kono Y, Hyodo T, Ishii K, Murakami M
    99th Radiological Society of North America, 2013年12月, Chicago, 国際会議

  • Aging Effect on Cerebral Blood Flow Measurements in Brain Perfusion Imaging with 3D Arterial Spin Labeling.
    Takahashi H, Ishii K, Kashiwagi N, Miyagoshi K, Matsuki M, Murakami M
    99th Radiological Society of North America, 2013年12月, Chicago, 国際会議

  • Cholangiolocellular Carcinoma: Comparison between Hemodynamic Pattern of Dynamic CT and Histopathologic Findings
    Tsurusaki M, Sofue K, Hyodo T, Okada M, Matsuki M, Murakami M, Ojima H
    99th Radiological Society of North America, 2013年12月, 国際会議

  • Diagnostic Efficacy of Gadoxetic Acid-enhanced MR Imaging in the Detection of Hepatic Metastasis from Colorectal Carcinoma: Prospective Comparison with Contrast-enhanced CT in the Same Patients
    Tsurusaki M, Hieda Y, Sofue K, Hyodo T, Matsuki M, Murakami M, Okada M, Arai Y
    99th Radiological Society of North America, 2013年12月, Chicago, 国際会議

  • Dual-Energy Computed Tomography for the Evaluation of Hypovascular Hepatic Metastases? Associations of the Optimal Monochromatic Level with Regard to the Metastasis-to-Liver Contrast Noise Ratio to Patient Size?
    Matsuki M, Murakami M, Hyodo T, Okada M, Tsurusaki M
    99th Radiological Society of North America, 2013年12月, Chicago, 国際会議

  • Quantitative Correlation between Liver Fat and Biopsy Score Using Multi-material Decomposition and Fast-kV Switching Dual-energy CT.
    Kudo M, Hyodo T, Murakami M, Lamb P, Mendonça PRS, Uemura M
    99th Radiological Society of North America, 2013年12月, Chicago, 国際会議

  • Comparison of Four Contrast Injection Protocols with a Combination of Fixed Injection Duration and Patients'Body-weight-Tailored Dose of Contrast Material for Multiphasic Hepatic CT: A Prospective Randomized Study
    Tsurusaki M, Sofue K, Hyodo T, Yagyu Y, Matsuki M, Murakami M, Okada M
    99th Radiological Society of North America, 2013年12月, Chicago, 国際会議

  • Applications of the Fast kVp Switching Dual Energy CT for Hepatopancreato-biliary Imaging.
    Hyodo T, Okada M, Kudo M, Tsurusaki M, Mochizuki T, Ishii K, Murakami M
    99th Radiological Society of North America, 2013年12月, Chicago, 国際会議

  • 後縦隔に発生したectopic neural tissueの1例
    朝戸信行, 松木 充, 福井秀行, 藤谷哲也, 任 誠雲, 千葉輝明, 高橋洋人, 兵頭朋子, 山田 穣, 柳生行伸, 鶴﨑正勝, 岡田真広, 柏木伸夫, 細川知紗, 小塚健倫, 今岡いずみ, 足利竜一朗, 石井一成, 村上卓道
    第305回日本医学放射線学会関西地方会, 2013年11月, 大阪, 国内会議

  • Optoease IVC filterが心腔へ逸脱した腎細胞癌下大静脈腫瘍塞栓の一例
    鶴﨑正勝, 朝戸信行, 福井秀行, 任 誠雲, 柳生行伸, 松木 充, 村上卓道
    第20回兵庫県IVR懇話会, 2013年11月, 第20回兵庫県IVR懇話会, 神戸, 国内会議

  • Role of Multimodality Fusion Imaging in HCC.
    村上卓道
    3rd APASL Single Topic Conference HCC IN 3D, 2013年11月, Cebu, 国際会議

  • ガイドラインから見た肝癌画像診断の進め方
    村上卓道
    第31回熊本肝癌研究会, 2013年11月, 第31回熊本肝癌研究会, 熊本, 国内会議

  • 画像診断ガイドラインからみた、肝癌画像診断の進め方
    村上卓道
    第49回日本医学放射線学会秋季臨床大会, 2013年10月, 名古屋, 国内会議

  • Dual energy CTによる肝脂肪変性の非侵襲的な定量
    澤井良之, 今井康陽, 村上卓道
    第55回日本消化器病学会大会, 2013年10月

  • Dual energy CTによる肝脂肪変性の非侵襲的な定量評価
    澤井良之, 今井康陽, 村上卓道
    第17回日本肝臓学会大会, 2013年10月, 東京, 国内会議

  • MRIで診断し得た妊娠中の卵巣捻転の一例
    山田 穣, 今岡いずみ, 柳生行伸, 岡田真広, 鶴﨑正勝, 松木 充, 村上卓道, 小谷泰史, 万代昌紀
    JSAWI2013, 2013年09月, 兵庫, 国内会議

  • 頭部造影MRIにおけるBlack Blood (BB) CUBE, BB CUBE-FLAIR法の有用性：1.5T・MR装置での検討
    任 誠雲, 足利竜一朗, 日高正二朗, 柳生行伸, 若山哲也, 三好光晴, 石井一成, 村上卓道
    第41回日本磁気共鳴医学会大会, 2013年09月, 第41回日本磁気共鳴医学会大会, 徳島, 国内会議

  • ASL-MR潅流画像によるAlzheimer's disease(AD)の診断においてBorderzonesignが与える影響
    高橋洋人, 石井一成, 柏木伸夫, 宮越敬三, 足利竜一朗, 松木 充, 村上卓道
    第41回日本磁気共鳴医学会大会, 2013年09月, 徳島, 第41回日本磁気共鳴医学会大会

  • 全肝ダイナミックスタディ
    村上卓道
    第41回日本磁気共鳴医学会大会, 2013年09月, 第41回日本磁気共鳴医学会大会, 徳島, 国内会議

  • 大腸癌肝転移早期発見における3T-MRIを用いたGd-EOB-DTPA造影MRIの有用性
    鶴﨑正勝, 稗田洋子, 祖父江慶太郎, 村上卓道
    日本消化器病学会近畿支部第99回例会, 2013年09月, 日本消化器病学会近畿支部第99回例会, 大阪, 国内会議

  • RFA治療における新しいoverlay機能を用いたシミュレーションの有用性に関する検討
    井倉 技, 牧野祐紀, 小来田幸世, 澤井良之, 福田和人, 村上卓道, 今井康陽
    第8回肝癌治療シミュレーション研究会, 2013年09月, 第8回肝癌治療シミュレーション研究会, 東京, 国内会議

  • 大腸癌肝転移の術前画像診断：Gd-EOB-DTPA造影MRIの有用性
    鶴﨑正勝, 祖父江慶太郎, 尾上俊介, 兵頭朋子, 岡田真広, 松木 充, 村上卓道
    第13回関西肝血流動態イメージ研究会, 2013年07月, 大阪, 国内会議

  • Volume Navigation におけるextracted-overlay functionを用いたRFA治療支援・効果判定
    牧野祐紀, 今井康陽, 小来田幸世, 澤井良之, 井倉 技, 福田和人, 村上卓道
    第13回関西肝血流動態イメージ研究会, 2013年07月, 大阪, 国内会議

  • 11C-PIB-PET SUV画像の視覚判定と定量評価
    細川知紗, 石井一成, 木村裕一, 兵頭朋子, 細野 眞, 坂口健太, 宇佐美公男, 村上卓道
    第46回日本核医学会近畿地方会, 2013年07月, 第46回日本核医学会近畿地方会, 大阪, 国内会議

  • EOB造影MRIとSonazoid造影USによる乏血性肝細胞癌の診断
    小来田幸世, 今井康陽, 中島 収, 兵頭朋子, 岡田真広, 井倉 技, 澤井良之, 福田和人, 関 康, 坂元亨宇, 工藤正俊, 村上卓道
    第49回日本肝癌研究会, 2013年07月, 第49回日本肝癌研究会, 東京, 国内会議

  • Volume Navigation systemにおけるextracted-overlay functionを用いたRFA治療支援・効果判定
    牧野祐紀, 井倉 技, 小来田幸世, 澤井良之, 福田和人, 今井康陽, 村上卓道
    第49回日本肝癌研究会, 2013年07月, 第49回日本肝癌研究会, 東京, 国内会議

  • 肝原発神経内分泌腫瘍の1例
    田中梨絵, 井上達夫, 千品寛和, 有住忠晃, 田北雅弘, 北井 聡, 矢田典久, 荻原 智, 南 康範, 上嶋一臣, 西田直生志, 工藤正俊, 兵頭朋子, 村上卓道
    第13回関西肝血流動態イメージ研究会, 2013年07月

  • 出血を繰り返した腹壁静脈門脈短絡に対して直接穿刺による硬化療法を施行した一例
    朝戸信行, 柳生行伸, 鶴﨑正勝, 日高正二朗, 任 誠雲, 柏木伸夫, 松木 充, 足利竜一朗, 村上卓道
    日本INTERVENTIONALRADIOLOGY学会第34回関西地方会, 2013年06月, 大阪, 国内会議

  • ポリドカノールフォームB-RTOにてショックを来した胃静脈瘤の1例
    鶴﨑正勝, 朝戸信行, 日高正二朗, 柳生行伸, 松木 充, 村上卓道, 丸山光也, 神山和俊, 中村友則
    日本INTERVENTIONALRADIOLOGY学会第34回関西地方会, 2013年06月, 大阪, 国内会議

  • 後腹膜原発のlipomatous hemangiopericytomaの1例
    朝戸信行, 鶴﨑正勝, 日高正二朗, 松久保祐子, 兵頭朋子, 柳生行伸, 岡田真広, 今岡いずみ, 松木 充, 足利竜一朗, 石井一成, 村上卓道
    第27回日本腹部放射線研究会, 2013年06月, 宇都宮, 国内会議

  • 消化管病変を伴ったSchonlein-Henoch紫斑病の3例
    日高正二朗, 松木 充, 任 誠雲, 兵頭朋子, 山田 穣, 柳生行伸, 鶴﨑正勝, 岡田真広, 柏木伸夫, 細川知紗, 小塚健倫, 今岡いずみ, 足利竜一朗, 石井一成, 村上卓道
    第304回日本医学放射線学会関西地方会, 2013年06月, 大阪, 国内会議

  • F-18 FDG-PET/CT検査にて経過観察しえた原発性肝神経内分泌腫瘍の1例
    兵頭朋子, 松木 充, 井上達夫, 木村雅友, 岡田真広, 柳生行伸, 鶴﨑正勝, 足利竜一朗, 石井一成, 村上卓道
    第27回日本腹部放射線研究会, 2013年06月, 宇都宮, 国内会議

  • Quantitative assessment of liver fat with dual energy CT: comparison with MR spectroscopy
    Hyodo T, Kudo M, Lamb P, Mendonca PRS, Okada M, Yada N, Maenishi O, Ishii K, Murakami T
    Computer Assisted Radiology and Surgery, 27th Intemational Congress and Exhibition, 2013年06月, ドイツ, 国際会議

  • 3D Artlrial spin labelingによるアルツハイマー病の脳潅琉画像：SPECTとの比較
    高橋洋人, 石井一成, 柏木伸夫, 宮越敬三, 花岡宏平, 村上卓道
    第72回日本医学放射線学会総会, 2013年04月, 横浜, 国内会議

  • Dual-energy CTによる肝脂肪定量：ファントム実験によるsingle-energy CTおよびMRSとの比較
    兵頭朋子, 岡田真広, 工藤正幸, 鶴﨑正勝, 足利竜一朗, 石井一成, 村上卓道
    第72回日本医学放射線学会総会, 2013年04月, 横浜, 国内会議

  • HCCに対する3Frシステムを用いたTACEはルーチンとなりうるか？
    鶴﨑正勝, 神山和俊, 安藤慎司, 中村 恩, 柳生行伸, 松木 充, 北垣 一, 村上卓道
    第72回日本医学放射線学会総会, 2013年04月, 横浜, 国内会議

  • Cholangiolocellular Carcinomas of the Liver: Multiphasic Helical CT Findings
    Tsurusaki M, Hidaka S, Sofue K, Ojima H, Hyodo T, Matsuki M, Murakami T
    The 4th Asian Congress of Abdominal Radiology, 2013年03月, Taiwan, 国際会議

  • Advanced MDCT imaging of the liver
    Murakami T
    The 4th Asian Congress of Abdominal Radiology, 2013年03月, Taiwan, 国際会議

  • Phantom study of liver fat quantification in dual-energy CT: comparison to single-energy CT and MR spectroscopy.
    Hyodo T, Okada M, Kudo M, Ishii K, Mochizuki T, Murakami T
    25th European Congress of Radiology, 2013年03月, Vienna, 国際会議

  • Desmoid tumors in the head and neck: MR imaging features.
    Arisawa A, Kashiwagi N, Murakami T, Nakanishi K, Tomiyama N
    25th European Congress of Radiology, 2013年03月, Vienna, 国際会議

  • 肝細胞癌におけるGb-EOB-DTPA造影MRI：撮像の最適化と診断機能
    村上卓道
    バイエル画像診断WEBカンファレンス, 2013年02月, 大阪, 国内会議

  • 頸椎における椎体内ガスと椎間板内ガスの頻度
    松久保祐子, 柏木伸夫, 上村正信, 辰巳幸代, 高橋洋人, 今岡いずみ, 鶴﨑正勝, 松木 充, 足利竜一朗, 石井一成, 村上卓道
    第42回神経放射線学会, 2013年02月, 北九州市, 国内会議

  • 放射線治療併用選択的動注化学療法にて、長期寛解が得られた耳下腺癌の一例
    柏木伸夫, 中西克之, 寺尾恭一, 村上卓道
    第42回神経放射線学会, 2013年02月, 北九州市, 国内会議

  • アルコール性肝障害に合併した多血性肝過形成結節の検討～画像所見を中心に～
    日高正二朗, 鶴﨑正勝, 兵頭朋子, 任 誠雲, 柳生行伸, 岡田真広, 松木 充, 足利竜一朗, 石井一成, 村上卓道
    第19回肝血流動態イメージ研究会, 2013年01月, 東京, 国内会議

  • Quantitative Evaluation of Hepatobiliary Function: A Compartment Model Analysis with Gadoxetic Acid-enhanced MRI
    Onoda M, Hyodo T, Okada M, Myati T, Murakami T, Uto T
    98th Radiological Society of North America, 2012年11月, アメリカ, 国際会議

  • The Usefullness of Conventional MR imaging in Establishing the Daiagnosis of Submandibular Pleomorphic Adenoma
    Kashiwagi N, Takahashi H, Maenishi O, Nakanishi K, Okajima K, Murakami T, Ishii K
    98th Radiological Society of North America, 2012年11月, アメリカ, 国際会議

  • Distinguishing Neurodegeneratice Dementia with MRI,FDG-PET,and PiB-PET
    Ishii K, Hyodo T, Yamada Y, Takahashi H, Okada M, Murakami T
    98th Radiological Society of North America, 2012年11月, アメリカ

  • Can Virtual Monochromatic Image with Dual-Energy CT Correct Beam Hardening Effect and Reduce Contrast Agent? Phantom Experiment.
    Kudo M, Hyodo T, Yamada K, Sengupta S, Murakami T
    98th Radiological Society of North America, 2012年11月, アメリカ, 国際会議

  • Endometrial Cancer:Preoperative Staging Using 3D T2-weighted Turbo Spin-Echo and Diffusion-weighted MR Imaging at 3.0 T
    Hori M, Kim T, Onishi H, Imaoka I, Murakami T, Tomiyama N
    98th Radiological Society of North America, 2012年11月, アメリカ, 国際会議

  • Preoperative Evaluation of Hepatocellular Carcinoma Between Gadoxetic Acid-enhanced MR Imaging and Contrast-enhanced CT Compared with Histopathological Examinations:A Multicenter, Phase Ⅲ study
    Tsurusaki M, Isoda H, Okada M, Sofue K, Sugimura K, Murakami T
    98th Radiological Society of North America, 2012年11月, アメリカ, 国際会議

  • Brain Perfusion Imaging of Alzheimer’s Disease with 3D Arterial Spin Labeling:Comparison with Brain Perfusion SPECT
    Takahashi H, Ishii K, Kashiwagi N, Miyakoshi K, Hanada K, Murakami T
    98th Radiological Society of North America, 2012年11月, アメリカ, 国際会議

  • Various Techniques of Interventional Repair for the Maintenance of Subcutaneous Autogenous Arteriovenous Fistula for Hemodialysis
    Tsurusaki M, Kamiyama K, Ando S, Nakamura M, Kitagaki H, Murakami T
    98th Radiological Society of North America, 2012年11月, アメリカ, 国際会議

  • 腫瘤形成した慢性顎下腺炎のFDG-PET/CT所見
    細川知紗, 柏木伸夫, 松久保祐子, 山田 穣, 任 誠雲, 兵頭朋子, 高橋洋人, 柳生行伸, 岡田真広, 小塚健倫, 今岡いずみ, 鶴﨑正勝, 松木 充, 足利竜一朗, 細野 眞, 石井一成, 村上卓道
    第302回日本医学放射線学会関西地方会, 2012年11月, 大阪, 国内会議

  • Preoperative Evaluation of Hepatocellular Carcinoma Between Gadoxetic Acid-enhanced MR Imaging and Contrast-enhanced CT Compared with Histopathological Examinations:A Multicenter, Phase ? study
    Tsurusaki M, Isoda H, Okada M, Sofue K, Sugimura K, Murakami T
    98th Radiological Society of North America, 2012年11月, アメリカ, 国際会議

  • How to Use Liver Imaging Reporting and Data System (LI-RADS) in Patients with Hepatocellular Carcinoma (HCC)
    Okada M, Murakami T, Numata K, Kudo M, Zech CJ, Nakano M
    98th Radiological Society of North America, 2012年11月

  • 認知症における脳FDG-PET早期撮像の可能性について
    兵頭朋子, 石井一成, 坂口健太, 花岡宏平, 宇佐美公男, 島元健次, 山添 譲, 山田 穣, 松木 充, 細野 眞, 村上卓道
    第52回日本核医学会学術総会, 2012年10月, 札幌, 国内会議

  • 最近の躯幹部MDCT診断
    村上卓道
    第3回市立川西病院医療連携勉強会, 2012年09月, 兵庫県, 国内会議

  • EOB-MRI肝細胞相におけるFlip angle(FA)の変化がコントラスト特性に与える影響
    西山大輔, 岡田真広, 若山哲也, 香川祐毅, 宮越敬三, 兵頭朋子, 高橋洋人, 今岡いずみ, 松木 充, 足利竜一朗, 石井一成, 村上卓道
    第40回日本磁気共鳴医学会大会, 2012年09月, 京都, 国内会議

  • レビー小体型認知症の頭頂側頭連合野の代謝低下はアミロイド沈着によらない
    石井一成, 兵頭朋子, 坂口健太, 花岡宏平, 宇佐美公男, 島本健次, 山添 譲, 山田 穣, 松木 充, 細野 眞, 村上卓道
    第45回日本核医学会近畿地方会, 2012年07月, 京都, 国内会議

  • 肝血行動態解析によるソラフェニブ治療効果の早期予測-CT perfusionを用いて
    兵頭朋子, 岡田真広, 香川祐毅, 日高正二朗, 任 誠雲, 柳生行伸, 上嶋一臣, 矢田典久, 工藤正幸, 石井一成, 工藤正俊, 村上卓道
    第48回日本肝癌研究会, 2012年07月, 石川, 国内会議

  • RFA治療効果判定におけるCT fusion imageの有用性
    牧野祐樹, 今井康陽, 井倉 技, 澤井良之, 小来田幸世, 福田和人, 大濱日出子, 宇都宮大輔, 水本 塁, 松本康史, 中原征則, 厨子慎一郎, 黒川正典, 磯谷圭介, 米澤 稔, 高村 学, 藤田典彦, 堀 雅敏, 村上卓道
    第48回日本肝癌研究会, 2012年07月, 石川, 国内会議

  • High risk noduleの自然経過と多血化因子
    今井康陽, 兵頭朋子, 岡田真広, 小来田幸世, 工藤正俊, 村上卓道
    第48回日本肝癌研究会, 2012年07月, 石川, 国内会議

  • 多血性肝細胞癌の検出：Gd-EOB-DTPA造影MRIとMDCTの比較
    金 東石, 大西裕満, 今井康陽, 堀 雅敏, 長野浩昭, 中矢泰裕, 坪山尚寛, 中本 篤, 巽 光朗, 熊野正士, 岡田真広, 高村 学, 若狭研一, 富山憲幸, 村上卓道
    第48回日本肝癌研究会, 2012年07月, 石川, 国内会議

  • 肝疾患の最新MDCT診断
    村上卓道
    第48回日本肝癌研究会, 2012年07月, 石川, 国内会議

  • Dual energy CTを用いた肝脂肪の定量評価：ファントム実験と初期臨床経験
    兵頭朋子, 岡田真広, 矢田典久, 前西 修, 香川祐毅, 任 誠雲, 柏木伸夫, 柳生行伸, 今岡いずみ, 松木 充, 足利竜一朗, 石井一成, 工藤正俊, 村上卓道
    第71回近畿大学医学会学術講演会, 2012年07月, 大阪, 国内会議

  • 子宮体癌リンパ節術後再発による消化管出血に対してcoveredstent留置およびコイル塞栓術を行った一例
    柳生行伸, 任 誠雲, 日高正二朗, 荒木哲朗, 足利竜一朗, 村上卓道, 中井英勝, 飛海孝子
    日本interventional radiology学会 第32回関西地方会, 2012年07月, 大阪, 国内会議

  • 放射線治療併用選択的動注化学療法にて、長期寛解が得られた耳下腺癌の一例
    柏木伸夫, 中西克之, 藤井 隆, 寺尾恭一, 西山謹司, 日高正二朗, 柳生行伸, 村上卓道
    日本interventional radiology学会 第32回関西地方会, 2012年07月, 大阪, 国内会議

  • CT perfusionによる肝血行動態解析：sorafenib投与による背景肝血流の変化と肝細胞癌治療効果
    兵頭朋子, 岡田真広, 香川祐毅, 日高正二朗, 柳生行伸, 上嶋一臣, 矢田典久, 松木 充, 足利竜一朗, 石井一成, 工藤正俊, 村上卓道
    第12回関西肝血流動態イメージ研究会, 2012年06月, 大阪, 国内会議

  • EOB造影MRIによる多血性肝細胞癌の診断-肝細胞造影相の有用性について
    今井康陽, 金 東石, 村上卓道
    第48回日本肝臓学会総会, 2012年06月, 第48回日本肝臓学会総会, 石川, 国内会議

  • Asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on MRI (AVIM)
    Ishii K, Murakami M, Okada M
    16th Workshops of Japanese-German Radiological Affiliation, 2012年05月, Munster, 国際会議

  • Imaging for liver fibrosis in patients with chronic liver disease: comparison between T1 mapping of Gd-EOB-DTPA enhanced MRI and US elastography
    Okada M, Murakami M, Ishii K
    16th Workshops of Japanese-German Radiological Affiliation, 2012年05月, Munster, 国際会議

  • Optimal scan timing of hepatocyte phase with Primocist-MRI using T1 mapping
    Murakami T
    International Primocist Advisory Board, 2012年05月

  • 耳下腺原発扁平上皮癌のMRI所見：病理所見との対比と考察
    高橋洋人, 柏木伸夫, 筑後孝章, 中西克之, 冨田裕彦, 村上卓道
    第71回日本医学放射線学会学術集会, 2012年04月, 横浜, 国内会議

  • HCCのカテーテル治療の最前線：TACE施行の精度を上げる？：Fligthplan for Liverと3D Roadmap
    村上卓道
    第71回日本医学放射線学術集会, 2012年04月, 横浜, 国内会議

  • Hypovascular nodules presenting with hypointensity in the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI in cirrhotic patients: Risk factors for hypervascularization. American Roentgen Ray Society Annual Meeting
    Hyodo T, Okada M, Kagawa Y, Kumano S, Imaoka I, Hori M, Ishii K, Imai Y, Mochizuki T, Kudo M, Murakami T
    JRS 2011 Annual Meeting award winning scientific electronic exhibits, 2012年04月, Vancouver, 国際会議

  • Dual energy CTを用いた肝脂肪の定量評価：ファントム実験と初期臨床経験
    兵頭朋子, 岡田真広, 矢田典久, 工藤正幸, 香川祐毅, 熊野正士, 石井一成, 工藤正俊, 村上卓道
    第71回日本医学放射線学会学術集会, 2012年04月, 横浜, 国内会議

  • 顎下腺多形腫瘍のMR像
    柏木伸夫, 筑後孝章, 中西克之, 岡嶋 馨, 友田 要, 高橋洋人, 森 一功, 村上卓道
    第71回日本医学放射線学会総会, 2012年04月, 国内会議

  • MDCTにおける肝臓の最適造影法と新しいCT撮像法
    村上卓道
    浜松放射線フォーラム2012, 2012年03月, 静岡, 国内会議

  • How to use Gd-EOB-DTPA in liver MRI: Breakthrough for the detection of early hepatocellular carcinoma
    Okada M, Christoph J.Zech, Imai Y, Maximilian Reiser, Murakami T
    24th Eeuroopean Congress of Radiology, 2012年03月, Vienna, 国際会議

  • The efficacy of contrast protocol in liver dynamic CT: multicentre prospective study in community hospitals in Japan. 24th European Congress of Radiology-Scientific Paper
    Okada M, Kondo H, Sou H, Murakami T, kanematsu M, Ichikawa T, Awai K, Yoshimitsu K, Yamashita Y
    24th European Congress of Radiology-Scientific Paper, 2012年03月, Vienna, 国際会議

  • The hepatocellular carcinoma to liver parenchyma contrast on Gd-EOB-DTPA enhanced MRI: Is the measured signal inetensity available for quantitative evaluation
    Morita T, Kumano S, Okada T, Hyodo T, Yagyu Y, Imaoka I, Ishii K, Ashikaga R, Murakami T
    24th Eeuroopean Congress of Radiology, 2012年03月, Vienna, 国際会議

  • 自然消退をきたした頚部デスモイド腫瘍の一例
    松久保祐子, 柏木伸夫, 柳生行伸, 小塚健倫, 熊野正士, 今岡いずみ, 石井一成, 足利竜一朗, 細野 眞, 西川正則, 森 一功, 佐藤隆夫, 村上卓道
    第300回日本医学放射線学会関西地方会, 2012年03月, 大阪, 国内会議

  • MDCTにおける肝臓の最適造影法
    村上卓道
    南大阪CT MEETING, 2012年02月, 大阪府, 国内会議

  • 頭頸部デスモイド腫瘍のMRI所見
    有澤亜津子, 柏木伸夫, 酒井美緒, 村上卓道, 冨田裕彦, 中西克之
    第23回骨軟部放射線研究会, 2012年01月, 東京, 国内会議

  • Interventional radiology における新しい支援画像「FightPlan」の初期臨床経験
    南 康範, 有住忠晃, 早石宗右, 田北雅弘, 北井 聡, 矢田典久, 井上達夫, 萩原 智, 上嶋一臣, 工藤正俊, 柳生行伸, 村上卓道
    第18回肝血流動態イメージ研究会, 2012年01月, 神戸, 国内会議

  • EOB造影MRIとSonazoid造影USによる早期肝細胞癌の検出
    小来田幸世, 今井康陽, 大濱日出子, 福田和人, 井倉 技, 澤井良之, 牧野祐紀, 関 康, 森本修邦, 高村 学, 中島 収, 村上卓道
    第18回肝血流動態イメージ研究会, 2012年01月

  • Assessment of hepatobiliary phase Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection ability versus MDCT.
    井上 達夫, 工藤 正俊, 有住 忠晃, 早石 宗右, 田北 雅弘, 北井 聡, 矢田 典久, 萩原 智, 南 康範, 上嶋 一臣, 岡田 真広, 兵頭 朋子, 村上 卓道
    The 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), 2011年11月, San Francisco, USA

  • Updated Liver Function Imaging by MRI and CT: Quantification Analysis for Hepatic Steatosis, Fibrosis, and Siderosis.
    Okada M, Wakayama T, Okuaki T, Kudo M, Kudo M, Murakami T
    RSNA - Educational Poster Session, 2011年11月, Chicago, 国際会議

  • Advanced CT Evaluation for Liver Imaging: Perfusion CT, Ultrafast Arterial Scanning of Whole Liver and Dual-Energy CT.
    Yamada K, Okada M, Kudo M, Yada N, Kudo M, Murakami T
    RSNA - Educational Poster Session, 2011年11月, Chicago

  • Atypical Imaging of Liver Hemangioma: Pictorial Review by Gd-EOB-DTPA-enhanced MRI, Dynamic CT and Sonography.
    Okada M, Numata K, Hyodo T, Kagawa Y, Kudo M, Murakami T
    RSNA - Scientific Poster Session, 2011年11月, Chicago, 国際会議

  • Hepatocellular Carcinoma: Pictorial Review for the Planning of Therapy and the Evaluation after Therapy.
    Okada M, Numata K, Hyodo T, Kagawa Y, Kudo M, Murakami T
    RSNA - Educational Poster Session, 2011年11月, Chicago

  • Evaluation of Angiogenesis after Antiangiogenic Therapy Using Liver CT Perfusion: Additional Detailed Capillary-level Hemodynamics in Patients with Advanced Hepatocellular Carcinoma.
    Okada M, Yada N, Ueshima K, Kudo M, Kudo M, Murakami T
    RSNA - Scientific Poster Session, 2011年11月, Chicago

  • Evaluation of Degree of Hepatic Fibrosis: Comparison T1 Mapping Technique of Gd-EOB-DTPA Enhanced MRI with US Elastography.
    Okada M, Yada N, Onoda M, Kumano S, Kudo M, Murakami T
    RSNA - Scientific Poster Session, 2011年11月, Chicago, 国際会議

  • Hypovascular Nodules on the Hepatobiliary Phase of Gd-EOB-DTPA Enhanced MRI in the Cirrhotic Liver: Baseline Patient Characteristics, MRI Findings and Tumor Growth Kinetics for Prediction of Hypervascularization .
    Hyodo T, Okada M, Hori M, Imai Y, Kudo M, Murakami T
    RSNA - Scientific Poster Session, 2011年11月, Chicago, 国際会議

  • Low Tube Voltage Technique CT with Iterative Reconstruction Increases Vascular Enhancement and Reduces Both Radiation Dose and the Amount of Iodine Contrast Agent in the Liver Dynamic Study.
    Takahashi H, Okada M, Hyodo T, Kagawa Y, Kudo M, Murakami T
    RSNA - Scientific Poster Session, 2011年11月, Chicago, 国際会議

  • Evaluation of Hepatic Enhancement of Gd-EOB-DTPA: Comparison of T1 Value and Signal Intensity
    Onoda M, Hyodo T, Murakami T, Okada M, Kumano S, Miyati T
    RSNA - Scientific Poster Session, 2011年11月, 国際会議

  • Preoperative Evaluation of Hepatocellular Carcinoma between Gadoxetic Acid-enhanced MR Imaging and Contrast-enhanced CT Compared with Histopatho logical Examinations A Multicenter, Phase III Study
    Tsurusaki M, Isoda H, Okada M, Shioyama Y, Sofue K, Arai Y
    RSNA - Scientific Poster Session, 2011年11月, Chicago, 国際会議

  • In Vitro Evaluation of Coronary Artery Stents by 64ch MDCT: Improvement in Luminal Visualization Using High Definition Scan Mode with Adaptive Statistical Iterative Reconstruction Technique.
    Hyodo T, Nakauchi Y, Yamada K, Kudo M, Mochizuki T, Murakami T, Okada M, Ishi K
    RSNA - Scientific Paper session, 2011年11月, Chicago., 国際会議

  • Distinguishing Idiopathic Normal Pressure Hydrocephalus from Neurodegenerative Diseases: Diagnostic Criteria, Imaging Characteristics, and Avoidance of Pitfalls.
    Ishii K, Kashiwagi N, Tsukabe A, Ashikaga R, Murakami T
    RSNA – Education Exhibits, 2011年11月, Chicago

  • Primary Squamous Cell Carcinoma of the Parotid Gland: A Pictorial Review
    Takahashi H, Kashiwagi N, Nakanishi K, Tomita T, Chikugo T, Murakami T
    RSNA – Education Exhibits, 2011年11月

  • Indium-111-Zevalin-SPECT/CT and FDG-PET/CT as quantitative evaluation in radioimmunotherapy for B-cell non-Hodgkin’s lymphoma
    Hanaoka K, Hosono M, Yamazoe Y, Tatsumi Y, Komeya Y, Tsuchiya N, Ishii K, Usami K, Murakami T, Uto T
    Annual Congress of the European Association of Nuclear Medicine, 2011年10月, Birmingham, 国際会議

  • ストロンチウム-89を2回投与した骨転移症例の検討
    米矢吉宏, 細野 眞, 土屋典生, 熊野正士, 山田 譲, 任 誠雲, 柳生行伸, 石井一成, 足利竜一朗, 西村恭昌, 村上卓道
    第51回日本核医学会学術総会, 2011年10月, 茨城, 国内会議

  • 慢性肝疾患においてEOB-MRI肝細胞相にみられる低信号乏血性結節の多血化と増大速度について
    岡田真広, 今井康陽, 村上卓道
    第15回日本肝臓学会大会, 2011年10月, 福岡, 国内会議

  • EOB造影MRIにて肝実質と肝細胞癌との定量的コントラストに用いる信号強度の有用性について
    森田敬裕, 熊野正士, 岡田真広, 兵頭朋子, 柳生行伸, 柏木伸夫, 小塚健倫, 今岡いずみ, 石井一成, 足利竜一朗, 村上卓道
    第39回日本磁気共鳴医学大会, 2011年09月, 福岡, 国内会議

  • Gd-EOB-DTPAの取り込み定量評価法の検討：T1値と信号値の比較
    小野田 農, 宮地利明, 西松和彦, 中塚隆之, 福島弘之, 上田 傑, 宇都辰郎, 村上卓道
    第39日本磁気共鳴医学大会, 2011年09月, 福岡, 国内会議

  • 最新の肝ＣＴ診断と治療への応用
    村上卓道
    神戸放射線診断・治療講演会, 2011年09月, 国内会議

  • 慢性肝疾患においてEOB－MRI肝細胞相にみられる低信号乏血性結節の多血化と増大速度について
    岡田真広, 今井康陽, 村上卓道
    第53回日本消化器病学会, 2011年09月, 福岡, 国内会議

  • 肝癌2次検診におけるEOB造影MRIの有用性についての検討
    今井康陽, 井倉 技, 村上卓道
    第53回日本消化器病学会, 2011年09月, 福岡, 国内会議

  • Assessment of hepatobiliary phase Gd-EOB-DTPA-Enhanced MRI for HCC and dysplastic nodules and comparison of detection ability versus MDCT.
    井上 達夫, 工藤 正俊, 北井 聡, 有住 忠晃, 南 康範, 上嶋 一臣, 岡田 真広, 村上 卓道
    International Liver Cancer Association Fifth Annual Conference (ILCA) 2011, 2011年09月, Hong Kong, China

  • 肝癌TACEにおける各種navigation imageの有用性 第2回大阪消化器画像・IVR研究会
    柳生行伸, 村上卓道
    第2回大阪消化器画像・IVR研究会, 2011年09月, 大阪, 国内会議

  • Initial Experience and Clinical Trial using GSI (Gemstone Spectrum Imaging) for liver disease.
    Murakami T
    Dual-Energy CT Update: Experience in Severance Hospital, 2011年09月, Seoul, 国際会議

  • Interventional radiologyにおける新しい支援画像「FlightPlan」の初期臨床経験.
    南 康範, 足立 哲平, 有住 忠晃, 早石 宗右, 田北 雅弘, 北井 聡, 矢田 典久, 井上 達夫, 萩原 智, 上嶋 一臣, 工藤 正俊, 村上 卓道, 柳生 行伸
    日本消化器病学会近畿支部第95回例会, 2011年08月, 大阪国際交流センター, 大阪

  • F-FDG PET/CT にてsuperscanを呈した腎癌骨転移の1例
    兵頭朋子, 石井一成, 細野眞, 阪本祐一, 米矢吉宏, 柳生行伸, 土屋典生, 熊野正士, 足利竜一朗, 中村一郎, 植村天受, 村上卓道
    第44回日本核医学会近畿地方会, 2011年07月, 兵庫, 国内会議

  • CT perfusionを用いた肝細胞癌に対するソラフェニブの効果判定の検討
    香川祐毅, 岡田真広, 兵頭朋子, 上嶋一臣, 矢田典久, 井上達生, 日高正二郎, 柳生行伸, 熊野正士, 柏木伸夫, 小塚健倫, 今岡いずみ, 足利竜一朗, 石井一成, 工藤正幸, 北野雅之, 工藤正俊, 村上卓道
    第11回関西肝血流動態イメージ研究会, 2011年07月, 国内会議

  • Correlation between biliary and liver enhancement on Gd-EOB-DTPA enhanced MR
    Okada M, Ishii K, Hyodo T, Kumano S, Kagawa Y, Yada N, Inoue T, Ueshima K, Kitano M, Kudo M, Murakami T
    The 2nd Asia-Pacific Primary Liver Cancer Expert Meeting, 2011年07月, 大阪, 国内会議

  • EOB-Primovist MRI of HCC: Toward ImprovedTreatment Decisions
    Murakami T
    The 2nd Asia-Pacific Primary Liver Cancer Expert Meeting, 2011年07月

  • ガドキセト酸ナトリウム造影MRI肝細胞相で低信号を呈する乏血性結節の多血化予測
    兵頭朋子, 岡田真広, 香川祐毅, 熊野正士, 任誠雲, 柏木伸夫, 柳生行伸, 今岡いずみ, 足利竜一朗, 石井一成, 工藤正俊, 村上卓道
    第70回近畿大学医学会学術講演会, 2011年07月

  • 高速多相性CT撮像を用いた動脈相12相による多血性肝細胞癌の濃染パターンの検討
    岡田真広, 香川祐毅, 兵頭明子, 熊野正士, 柳生行伸, 今井康陽, 足利竜一朗, 石井一成, 工藤正俊, 村上卓道
    第47回日本肝癌研究会, 2011年07月

  • 慢性肝疾患においてEOB-MRI肝細胞相で低信号を示す乏血性結節の多血化に関する因子の検討
    小来田幸世, 今井康陽, 兵頭朋子, 岡田真広, 香川祐毅, 澤井良之, 井倉 技, 熊野正士, 堀 雅敏, 工藤正俊, 村上卓道
    第47回日本肝臓学会総会, 2011年06月, 国内会議

  • 外傷性神経腫の1例
    藤谷哲也, 柏木伸夫, 前西 修, 楠原廣久, 磯貝典孝, 今岡いずみ, 熊野正士, 石井一成, 足利竜一朗, 村上卓道
    第298回日本医学放射線学会関西地方会, 2011年06月, 大阪

  • 慢性肝疾患においてEOB-MRI肝細胞相で低信号を示す乏血性結節の多血化に関与する因子の検討.
    小来田幸世, 今井康陽, 兵頭朋子, 岡田真広, 香川祐毅, 澤井良之, 井倉 技, 熊野正士, 堀 雅敏, 工藤正俊, 村上卓道
    第47回日本肝臓学会総会, 2011年06月

  • Clinical impact of CT attenuation correction by SPECT/CT in brain perfusion images.
    Ishii K, Hanaoka K, Okada M, Kumano S, Komeya Y, Tsuchiya N, Hosono M, Murakami T
    2011 Annual Meeting of Society of Nuclear Medicine, 2011年06月, San Antonio, 国際会議

  • 小腸イレウスをきたした硬化性腸間膜炎の1例
    兵頭朋子, 熊野正士, 津田孝治, 上田和毅, 杉浦史哲, 前西 修, 木村雅友, 望月輝一, 村上卓道
    第25回日本腹部放射線研究会, 2011年06月, 大阪

  • Detachable coilのアンラベルに対してgooseneck snareでコイル除去を行った一例
    柳生行伸, 任誠雲, 朝戸信行, 香川祐毅, 森田敬裕, 日高正二朗, 柏木伸夫, 足利竜一朗, 村上卓道
    日本IVR学会 第30回関西地方会 第51回関西INTERVENTIONAL RADIOLOGY研究会, 2011年06月

  • 耳下腺粘表皮癌におけるMRI所見と組織学的悪性度との関連性の検討
    柏木 伸夫, 土手 健作, 村上 卓道, 川野 潔
    第70回日本医学放射線学会総会, 2011年05月, Web開催, 国内会議

  • 耳下腺多形腺腫由来癌のMRI所見
    柏木 伸夫, 筑後 孝章, 村上 卓道, 川野潔
    第70回日本医学放射線学会総会, 2011年05月, Web開催, 国内会議

  • Gd-EOB-DTPA造影MRI肝細胞相で検出された慢性障害肝の乏血性結節：多血化の危険因子
    兵頭 朋子, 岡田 真広, 村上 卓道, 堀 雅敏, 今井康陽
    第70回日本医学放射線学会学術集会, 2011年05月, Web開催, 国内会議

  • ＥＯＢプリモビストＭＲＩで肝画像診断は決まりか！？ 治療前（手術前）評価として「経静脈性造影検査で十分」
    村上卓道
    第1回Advanced MR研究会, 2011年05月, 大阪

  • Gd-EOB-DTPA造影剤MRIにおけるHCCのT1値の経時的変化について－T1 mappingを用いた定量的な検討
    森田敬裕, 熊野 正士, 村上 卓道
    第70回日本医学放射線学会学術集会, 2011年05月, Web開催

  • SSFSE像におけるHCCに対するEOB造影の経時的影響：1.5Tと3.0Tの比較
    荒木哲朗, 岡田真広, 熊野正士, 柳生行伸, 柏木伸夫, 小塚健倫, 今岡いずみ, 石井一成, 足利竜一朗, 村上卓道
    第70回日本医学放射線学会学術集会, 2011年05月, Web開催

  • Hypovascular nodules presented with hypointensity on the hepatobiliary phase of Gd-EOB-DTPA enhanced MRI in the cirrhotic liver: Implications for developing hypervascular hepatocellular carcinoma.
    Hyodo T, Okada M, Kagawa Y, Kogita S, Kumano S, Imaoka I, Hori MI, K, Imai Y, Mochizuki T, Kudo M, Murakami T
    The International Society for Magnetic Resonance in Medicine 19th Annual Meeting., 2011年05月, 国際会議

  • Reproducibility of Apparent Diffusion Coefficients in the Normal Uterus During the Menstrual Cycle at 3T MR Imaging.
    Tsukabe A, Imaoka I, Araki T, Nishimatsu K, Okada M, Kumano S, Ishii K, Ashikaga R, Cauteren MV, Murakami T
    The International Society for Magnetic Resonance in Medicine 19th Annual Meeting., 2011年05月, Montreal, 国際会議

  • Evaluation of the Effectiveness of Slice Selective Gradient Reversal Technique in Diffusion Weighted Imaging of the Female Pelvis at 3T MR Imaging.
    Tsukabe A, Imaoka I, Araki T, Nishimatsu K, Okada M, Kumano S, Ishii K, Ashikaga R, Cauteren MV, Murakami T
    The International Society for Magnetic Resonance in Medicine 19th Annual Meeting., 2011年05月, Montreal, 国際会議

  • 膵Perfusion検査におけるパラメーター正常値の検討；Milesらの論文との比較
    岡田真広, 香川祐毅, 兵頭朋子, 熊野正士, 工藤正幸, 北野雅之, 工藤正俊, 竹山宣典, 村上卓道
    第2回膵Perfusion CT画像研究会, 2011年05月, 東京, 国内会議

  • Optimal parameter setting for hepatobiliary phase of Gd-EOB-DTPA enhanced liver MRI
    Okada M, Ishii K, Kagawa Y, Hyodo T, Wakayama T, Kumano S, Murakami T
    The 3rd Asian Congress of Abdominal Radiology (ACAR),, 2011年05月, Beijing, 国際会議

  • Innova 4100 の最新IVR支援機能の使用経験と将来展望
    村上卓道
    第40回日本IVR学会, 2011年05月, 青森, 国内会議

  • 肝臓内脂肪蓄積量の定量評価と２型糖尿病における病態解析
    村田佳織, 川畑由美子, 山内孝哲, 能宗伸輔, 原田剛史, 馬場谷 成, 廣峰義久, 伊藤裕進, 森口将典, 山片里美, 東本貴弘, 朴 忠勇, 武友保憲, 塚部明大, 岡田真広, 村上卓道, 池上博司
    第54回日本糖尿病学会年次学術集会, 2011年05月, 札幌市, 国内会議

  • Assessment of hepatobilliary phase Gd-EOB-DTPA-Enhanced MRI for HCC and borderline lesions and comparison of detection ability versus MDCT.
    井上 達夫, 工藤 正俊, 岡田 真広, 村上 卓道, 小無田, 美菜, 坂元, 亨
    Digestive Disease Week (DDW) 2011, 2011年05月, Chicago, USA

  • MDCT and MR imaging of Hepatobiliary and Pancreatic disease
    Murakami T
    The 3rd Asian Congress of Abdominal Radiology (ACAR), 2011年05月

  • Hypovascular nodules presented with hypointensity on the hepatobiliary phase of Gd-EOB-DTPA enhanced MRI in the cirrhotic liver: Clinical implications
    Hyodo T, Okada M, Kagawa Y, Kogita S, Kumano S, Hori M, Mochizuki T, Kudo M, Murakami T
    The 23rd European Congress of Radiology - Scientific Paper, 2011年03月, Vienna, 国際会議

  • Carcinoma ex pleomorphic adenoma of the parotid gland: MR imaging findings with pathologic correlation
    Kashiwagi N, Yamada D, Chikugo H, Tomita Y, Nakanishi K, Kawano T, Murakami T
    The 23rd European Congress of Radiology-Scientific Paper, 2011年03月, Vienna, 国際会議

  • Gd-EOB-DTPA造影MRI肝細胞相で低信号を呈する乏血性結節の多血化について
    兵頭朋子, 岡田真広, 香川祐毅, 小来田幸世, 熊野正士, 今岡いずみ, 堀 雅俊, 石井一成, 今井 康陽, 望月 輝一, 工藤正俊, 村上 卓道
    日本消化器学会近畿支部第94回例会, 2011年02月, 大阪国際会議場，大阪

  • 大腿四頭筋血腫の経過で隣接骨の皮質過形成をきたした一例
    森田敬裕, 柏木伸夫, 柳生行伸, 小塚健倫, 熊野正士, 今岡いずみ, 石井一成, 足利竜一朗, 村上卓道
    第297回日本医学放射線学会関西地方会, 2011年02月, 大阪, 国内会議

  • 肝癌のCT・MRI診断～抽出から機能まで
    村上卓道
    第17回南阪神肝疾患病診連携セミナー, 2011年02月, 大阪, 国内会議

  • EOB-MRI肝細胞相のみ同定し得た乏血性高分化型肝細胞癌 ? Volume Navigaionを用いた診断及び穿刺治療
    大濱日出子, 井倉 技, 今井康陽, 福田和人, 澤井良之, 小来田 幸世, 土本 雄亮, 牧野祐紀, 水本 塁, 宇都宮大輔, 岩崎哲也, 中松 大, 松本康史, 中原征則, 厨子 慎一郎, 黒川正典, 関 康, 高村 学, 竹内 真, 村上 卓道
    第17回肝血流動態イメージ研究会, 2011年01月, 横浜, 国内会議

  • Gd-EOB-DTPA造影MRI肝細胞相にて低信号を呈する乏血性結節：多血化予測は可能か
    兵頭朋子, 岡田真広, 香川祐毅, 小来田 幸世, 熊野正士, 今岡いずみ, 堀 雅俊, 石井一成, 今井康陽, 望月輝一, 工藤正俊, 村上卓道
    第17回肝血流動態イメージ研究会, 2011年01月, 横浜, 国内会議

  • Update of Dose Reduction Strategies Using 64-Detector Cardiac CT Imaging
    工藤 正幸, 岡田 真広, 村上 卓道
    RSNA - Scientific Poster Session, 2010年11月, RSNA - Scientific Poster Session, Chicago, 国際会議

  • RI標識モノクローナル抗体療法におけるIn-Zevalin, FDGの腫瘍集積と奏功について
    花岡宏平, 細野 眞, 村上 卓道
    第50回日本核医学会学術総会, 2010年11月, 埼玉

  • Incidence and Risk Factors of Developing Hypervascular Hepatocellular Carcinoma from Hypo-intense Nodules at Hepatobiliary Phase of Gd-EOB-DTPA-enhanced MRI in Patients with Chronic Liver Disease
    岡田 真広, 香川 祐毅, 村上 卓道, 堀 雅敏
    RSNA - Scientific Poster Session, 2010年11月, Chicago, 国際会議

  • CT Perfusion Imaging in Abdomen Made Easy
    荒木 哲朗, 岡田 真広, 村上 卓道, 工藤 正幸
    RSNA - Scientific Poster Session, 2010年11月, Chicago, 国際会議

  • Optimal Imaging Delay of Dynamic CT for Hypervascular Hepatocellular Carcinomas: Investigation by Continuous Ultrafast Arterial Scanning of Whole Liver
    香川 祐毅, 岡田 真広, 村上 卓道
    RSNA - Scientific Poster Session, 2010年11月, Chicago, 国際会議

  • Primovist MR Imaging of Liver Tumor ? Towards Improved Treatment Decision.
    村上 卓道
    2nd Asia Pacfic Bayer Scharing Expert Syposium on Targeted Therapy 2010., 2010年10月, Seoul

  • Definition of target volumes by PET/CT for radiation therapy planning using moving phantom.
    花岡 宏平, 村上 卓道
    European Association of Nuclear Medicine, 2010年10月, vienne, 国際会議

  • Can Gd-EOB-DTPA-enhanced MRI discriminate between dysplastic nodules and early-to- well-differentiated HCC?
    井上 達夫, 工藤 正俊, 早石 宗右, 上田 泰輔, 田北 雅弘, 北井 聡, 畑中 絹世, 矢田 典久, 萩原 智, 南 康範, 鄭 浩柄, 上嶋 一臣, 岡田 真広, 熊野 正士, 村上 卓道, 坂元 亨宇
    18th United European Gastroenterology Week (UEGW) 2010, 2010年10月, Barcelona, Spain

  • 肝臓EOB造影MRI診断
    村上 卓道
    INNOVATIVE AZE 2010 TOKYO, 2010年09月, 東京, 国内会議

  • 乳幼児心臓CTA検査における造影剤濃希釈法の検討
    河野 雄輝, 山田 浩司, 村上 卓道
    第27回日本放射線技術総合学術大会, 2010年09月, 青森, 国内会議

  • ３T MRIを用いた正常子宮T１値、T２*値の測定
    荒木哲朗, 塚部明大, 村上 卓道
    第38回日本磁気共鳴医学会大会, 2010年09月, つくば

  • ３T MRIを用いた月経周期における正常子宮のADC値評価
    塚部明大, 荒木哲朗, 村上 卓道
    第38回日本磁気共鳴医学会大会, 2010年09月, つくば

  • Publication of Academic Journal: Situation in Japan
    村上 卓道
    Asian Radiology Round Table Symposia., 2010年08月, Jeju Korea

  • 各種画像診断の基礎と医療裁判における画像診断の不確実性
    村上 卓道
    「医師と語る」, 2010年07月, 大阪, 国内会議

  • EOB造影MRI
    村上 卓道
    第56回千駄木肝カンファレンス, 2010年07月, 東京, 国内会議

  • 進行型肝細胞癌に対するSorafenib治療効果判定における肝CT Perfusion検査
    岡田 真広, 村上 卓道
    第10回関西肝血流動態イメージ研究会, 2010年07月, 大阪

  • 肝細胞癌におけるEOB造影MRIの造影パターンの多様性についての検討
    小来田 幸世, 村上 卓道
    第10回関西肝血流動態イメージ研究会, 2010年07月, 大阪

  • MDCTが術前に有用であった仮性胸部大動脈瘤の１例
    中内 祥文, 村上 卓道
    第７１回心臓血管放射線研究会, 2010年07月, 熊本

  • 高速多相撮像を用いた多血性肝細胞癌の最適撮像時間の検討.
    香川 祐毅, 村上 卓道
    第295回日本医学放射線学会関西地方会, 2010年07月, 大阪

  • 呼吸同期装置を用いない呼吸同期SPECT法の検討.
    坂口健太, 村上 卓道
    第43回 日本核医学会近畿地方会, 2010年07月, 大阪

  • ストロンチウム-89を2回投与した骨転移症例の検討.
    米矢 吉宏, 村上 卓道
    第43回 日本核医学会近畿地方会, 2010年07月, 大阪

  • 肝・胆・膵のMRI MRCP診断
    村上 卓道
    第4回神鋼病診連携消化器病懇話会, 2010年07月, 神戸, 国内会議

  • MDCTでの腹部領域における最新技術および最新情報～４D Imaging を中心に～
    村上 卓道
    第２６回三重総合画像研究会, 2010年06月, 三重, 国内会議

  • 進行型肝細胞癌症例に対するSorafenib治療前後の肝CT Perfusion検査
    岡田 真広, 村上 卓道
    第2回日本肝がん分子標的治療研究会, 2010年06月, 東京, 国内会議

  • 卵巣漿液性腺癌と成熟嚢胞性奇形腫のcollision tumorの1例
    加藤里枝子, 村上 卓道
    第24回腹部放射線研究会, 2010年06月, 軽井沢

  • 残胎盤による出血に対して子宮動脈塞栓術で子宮温存治療ができた1例
    朝戸 信行, 村上 卓道
    日本IVR学会第28会関西地方会, 2010年06月, 大阪

  • EOB造影MRIによる多血性肝細胞癌診断におけるsubtraction画像の有用性
    土本 雄亮, 香川 祐毅, 岡田 真広, 村上 卓道, 今井 康陽
    第46回日本肝臓学会総会, 2010年05月, 山形, 国内会議

  • Gd-EOB-DTPA造影MRIによる多血性肝細胞癌および乏血性肝細胞癌の抽出能の検討
    井倉 技, 岡田 真広, 村上 卓道, 今井 康陽
    第46回日本肝臓学会総会, 2010年05月, 山形, 国内会議

  • 肝細胞癌におけるEOB造影MRI肝細胞相の造影効果－組織分化度および門脈血流との対比
    小来田 幸世, 岡田 真広, 村上 卓道
    第46回日本肝臓学会総会, 2010年05月, 山形, 国内会議

  • Conebeam CTを用いた血管系IVR
    村上 卓道
    第39回日本IVR学会総会, 2010年05月, 国内会議

  • 油性造影剤マイオジールの頭蓋内MRI所見についての検討
    下野 太郎, 村上 卓道
    第69回日本医学放射線学会学術集会, 2010年04月, 横浜

  • Gd‐EOB‐DTPA造影MRIと肝機能評価：T1 Mapping法を用いて
    勝部 敬, 村上 卓道
    第69回日本医学放射線学会学術集会, 2010年04月, 横浜

  • ３T MRI高分解能画像による正常子宮の蠕動評価
    安藤理奈, 村上 卓道
    第69回日本医学放射線学会学術集会, 2010年04月, 横浜

  • MRIおよびCTを用いた画像的肝機能評価
    岡田 真広, 村上 卓道
    第69回日本医学放射線学会学術集会, 2010年04月, 横浜

  • SPECT/CTによる脳血流SPECTの減弱補正効果
    栗生 明博, 村上 卓道
    第69回日本医学放射線学会学術集会, 2010年04月, 横浜

  • 肝癌画像診断と肝動脈塞栓療法の最新の動向
    村上 卓道
    肝癌診療の最前線～ミリプラ新発売記念講演会～, 2010年04月, 大阪

  • CT/MRIを用いた肝機能診断
    村上 卓道
    第1回膵 Perfusion CT画像研究会, 2010年04月, 新潟

  • 造影MRIによる多血性肝細胞癌におけるsubtraction画像の有用性
    土本 雄亮, 村上 卓道
    第96回日本消化器病学会総会, 2010年04月, 新潟

  • CT/MRIを用いた部分肝機能診断
    村上 卓道
    Perfusion CTを用いた重症急性膵炎予後予測に関する検討会, 2010年03月, 京都

  • Gd-EOB-DTPA造影MRIでの肝機能評価の試み：T1mappingを用いて
    勝部 敬, 村上 卓道
    第294回日本医学放射線学会関西地方会, 2010年02月, 大阪

  • 肝細胞癌検出における肝ダイナミックCTの至適造影剤投与量の検討
    藤谷 哲也, 村上 卓道
    第294回日本医学放射線学会関西地方会, 2010年02月, 大阪

  • 慢性GVHDに伴う舌papillomatosisから発生した舌癌の一例
    加藤里枝子, 村上 卓道
    第294回日本医学放射線学会関西地方会, 2010年02月, 大阪

  • 消化器領域における画像診断の新展開 肝細胞癌におけるEOB造影MRI肝細胞相の造影効果－組織分化度および門脈血流との対比
    小来田 幸世, 村上 卓道
    日本消化器病学会近畿支部 第92回例会, 2010年02月, 大阪

  • 肝細胞癌の治療方針決定におけるEOB-MRIの役割
    村上 卓道
    第29回日本画像医学会, 2010年02月, 東京

  • Malignancy grading of primary hepatocellular carcinoma by liver-specific contrast agent and hemodynamic alteration
    岡田 真広, 熊野 正士, 工藤 正俊, 村上 卓道
    Radiological Society of North America 2009 95th Scientific Assembly and Annual Meeting(RSNA), 2009年12月, Chicago,USA

  • Hypervascular Hepatocellular Carcinomas: Detection with Gd-EOB-DTPA-enhanced MR Imaging and Contrast-enhanced Dynamic MDCT.
    大西 裕満, 村上 卓道
    95th Radiological Society of North America., 2009年12月, Chicago

  • Update of Liver Functional Imaging for Diffuse and Focal Liver Disease: Hepatic Perfusion CT and Liver-specific Contrast-enhanced MR.
    岡田 真広, 栗生 明博, 村上 卓道
    95th Radiological Society of North America., 2009年11月, chicago

  • The Updated Imaging Diagnosis of Malignant Lymphoma Based on WHO Classification.
    岡田 真広, 香川 祐毅, 村上 卓道
    95th Radiological Society of North America., 2009年11月, chicago

  • Patterns of Local Recurrence of Hepatocellular Carcinoma and Liver Metastasis after Radiofrequency Ablation and Transcatheter Arterial Chemoembolization: Analysis by Multimodality Imaging.
    勝部 敬, 岡田 真広, 村上 卓道
    95th Radiological Society of North America., 2009年11月, chicago

  • Comparison of Enhancement Patterns of Histologically Confirmed Hepatocellular Carcinoma between Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid- and Ferucarbotran- enhanced Magnetic Resonance Imaging.
    岡田 真広, 村上 卓道, 今井 康陽
    95th Radiological Society of North America, 2009年11月, chicago

  • Malignancy Grading of Primary Hepatocellular Carcinoma by Liver-specific Contrast Agent and Hemodynamic Alteration.
    岡田 真広, 村上 卓道, 今井 康陽
    95th Radiological Society of North America, 2009年11月, chicago

  • Preliminary Study for Liver Fat Fraction and T2* Measurement with T2*-weighted MR Imaging in Experimental Rats with Nonalcoholic Steatohepatitis.
    岡田 真広, 勝部 敬, 村上 卓道
    95th Radiological Society of North America., 2009年11月, chicago

  • Correlation of Hepatic Function and Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid -enhanced Magnetic Resonance: Analysis by Using T2* Mapping.
    勝部 敬, 岡田 真広, 村上 卓道
    95th Radiological Society of North America., 2009年11月, chicago

  • Optimal Contrast D ose for Depiction of Hypervascular HCC at Dynamic MDCT.
    熊野 正士, 村上 卓道
    95th Radiological Society of North America., 2009年11月, chicago

  • 4Dスキャン－Volume Helical Shuttleの開発と臨床応用
    村上 卓道
    GECT Advanced Technology Symposium, 2009年11月, 大阪

  • 腹部領域の最新画像診断・IVR
    村上 卓道
    草津栗東医師会学術講演会, 2009年11月, 草津

  • 肝細胞癌のMRI診断CTとの棲み分け
    村上 卓道
    第37回日本磁気共鳴医学会大会, 2009年10月, 第37回日本磁気共鳴医学会大会, 横浜, 国内会議

  • EOB・プリモビストの肝細胞癌診断アルゴリズムに与えるインパクト
    村上 卓道
    JDDW, 2009年10月, JDDW, 京都

  • NASHモデルラットにおけるSPIO造影 MRI投与前後のT2＊Valueの評価
    岡田 真広, 勝部 敬, 村上 卓道
    第37回日本磁気共鳴医学会大会, 2009年10月, 横浜, 国内会議

  • ３D-T2強調像による女性骨盤内血管の抽出の検討
    森田敬裕, 今岡 いずみ, 村上 卓道
    第37回日本磁気共鳴医学会大会, 2009年10月, 横浜, 国内会議

  • 32 channel coil を用いた3T EOB-Primovist-MRI:6 channel coil との比較
    熊野 正士, 岡田 真広, 村上 卓道
    第37回日本磁気共鳴医学会大会, 2009年10月, 横浜, 国内会議

  • Gd-EOB-DTPA造影MRIと肝機能評価：T１ Mapping法を用いて
    勝部 敬, 岡田 真広, 村上 卓道
    第37回日本磁気共鳴医学会大会, 2009年10月, 横浜, 国内会議

  • 3T32chコイルシムテムによるGd-EOB-DTPA造影剤MRI
    村上 卓道
    第37回日本磁気共鳴医学会大会, 2009年10月, 横浜, 国内会議

  • recovery coefficient (RC) ?SUV補正を用いた食道癌のリンパ節転移の評価
    米矢 吉宏, 細野 眞, 村上 卓道
    第49回日本核医学会学術総会, 2009年10月, 第49回日本核医学会学術総会, 旭川市, 国内会議

  • 腹部領域MDCTの最新動向
    村上 卓道
    第51回日本消化器画像診断研究会, 2009年09月, 第51回日本消化器画像診断研究会, 仙台

  • EOBあるいはSPIO造影MRI T2*valueの評価：正常肝ラットとNASHラットの対比
    岡田 真広, 村上 卓道
    第4回肝癌治療シミュレーション研究会, 2009年09月, 第4回肝癌治療シミュレーション研究会, 神戸

  • Nonalcoholic steatohepatitis (NASH）with MR imaging : Usefulness of liver fat fraction and T2* measurement in experimental rats.
    岡田 真広, 村上 卓道
    2009年09月, Bologna

  • 新しい肝特異性造影剤Gd-EOB-DTPAを用いたMRI画像診断の役割と可能性
    岡田 真広, 村上 卓道
    第45回日本肝癌研究会, 2009年07月, 第45回日本肝癌研究会, 福岡

  • Gd-EOB-DTPA－MRIによる早期肝細胞癌の診断－組織分化度および門脈血流との対比
    小来田幸世, 村上 卓道
    第45回日本肝癌研究会, 2009年07月, 第45回日本肝癌研究会, 福岡

  • 肝細胞癌検出におけるGd=EOB-DTPA造影MRIとSonazoid造影超音波との比較
    今井康陽, 村上 卓道
    第45回日本肝癌研究会, 2009年07月, 第45回日本肝癌研究会, 福岡

  • EOB・プリモビスト造影MRIの動脈相におけるアーテファクトの原因とその対策について
    村上 卓道
    第3回関西EOB・プリモビストセミナー, 2009年07月, 第3回関西EOB・プリモビストセミナー, 大阪

  • 拡散強調像で大脳白質に広範な高信号を認めたShaken Baby Syndromeの一例
    朝戸信行, 下野 太郎, 村上 卓道
    第292回関西地方会, 2009年07月, 第292回関西地方会, 大阪, shaken baby syndromeの1例を解説報告した。, 国内会議

  • Estimation of Hepatic Function by T2* Value Mapping with Gadolinium-Ethocybenzyl-Diethylenetriamine Pentaacetic Acid Enhanced Magnetic Resonance Imaging.
    勝部 敬, 村上 卓道
    The 2nd Asian Congress of Abdominal Radiology (ACAR), 2009年06月, The 2nd Asian Congress of Abdominal Radiology (ACAR), Seoul

  • The optimal scan time of Gd-EOB-DTPA enhanced MR cholangiography and comparison with conventional unenhanced MRCP.
    岡田 真広, 村上 卓道
    The 2nd Asian Congress of Abdominal Radiology (ACAR), 2009年06月, The 2nd Asian Congress of Abdominal Radiology (ACAR), Seoul

  • 肝臓.消化器画像診断の最前線；CT・MRIと中心に
    村上 卓道
    日本消化器病学会近畿支部第30回教育講演会, 2009年06月, 日本消化器病学会近畿支部第30回教育講演会, 京都

  • 早期肝癌診断におけるGd-EOB-DTPA-MRIの有用性について
    小来田幸世, 村上 卓道
    第45回日本肝臓学会総会, 2009年06月, 第45回日本肝臓学会総会, 神戸, 国内会議

  • 右後腹膜気管支原性嚢胞の１例 第23回腹部放射線研究会
    松久保祐子, 村上 卓道
    第23回腹部放射線研究会, 2009年06月, 第23回腹部放射線研究会, 岡山

  • Measurement of regional cerebral blood flow associated with cilostazol tehrapy in vascular dementia.
    花田 一志, 細野 眞, 村上 卓道
    ISM 2009 Annual Meeting, 2009年06月, ISM 2009 Annual Meeting, Tront, 国際会議

  • Assessment of lymph node metastasis in esophageal cancer with SUV correction based on count recovery on 18F-FDG PET/CT.
    米矢 吉宏, 細野 眞, 村上 卓道
    ISM2009 Annual Meeting, 2009年06月, ISM2009 Annual Meeting, Toronto, 国際会議

  • 三次元・四次元画像を用いた最新の躯幹部画像診断・IVR
    村上 卓道
    日本歯科放射線学会第50回記念学術大会, 2009年05月, 日本歯科放射線学会第50回記念学術大会, 大阪

  • ワークショップ：肝胆膵領域の画像診断の進歩 肝細胞癌診断におけるGd-EOB-DTPA-MRIの有用性について
    今井康陽, 村上 卓道
    第95回日本消化器病学会, 2009年05月, 第95回日本消化器病学会, 札幌

  • コーンビームCTを用いてコイル塞栓術を施行した内臓動脈瘤の2例
    栗生 明博, 村上 卓道, 足利 竜一朗
    第38回日本IVR学会総会, 2009年05月, 第38回日本IVR学会総会, 大阪, 国内会議

  • マルチモダリティーイメージングによるIVR支援
    村上 卓道
    第38回IVR学会総会, 2009年05月, 第38回IVR学会総会, 大阪, 国内会議

  • 最新肝画像診断，IVR治療
    村上 卓道
    第68回日本医学放射線学会学術集会, 2009年05月, 第68回日本医学放射線学会学術集会, 横浜, 国内会議

  • Signal intensity changes during physiological movement: comparison of uterine myometrium and myocardium.
    荒木哲郎, 村上 卓道
    International Society for Magnetic Resonance in Medicine., 2009年04月, International Society for Magnetic Resonance in Medicine., Honolulu.

  • Gd-EOB-DTPAと肝機能との相関：T2＊Map-ping法を用いて
    勝部 敬, 岡田 真広, 村上 卓道
    第68回日本医学放射線学会学術集会, 2009年04月, 第68回日本医学放射線学会学術集会, 横浜, 国内会議

  • Reconery Cofficient(RC)-SUV部分容積効果補正による肺癌リンパ節転移の評価
    米矢 吉宏, 細野 眞, 村上 卓道
    第68回日本医学放射線学会学術集会, 2009年04月, 第68回日本医学放射線学会学術集会, 横浜, 国内会議

  • 胃癌原発巣の化学療法効果判定：MDCTを用いた胃癌壁厚測定の有用性
    熊野 正士, 桑原 雅知, 村上 卓道
    第68回日本医学放射線学会学術集会, 2009年04月, 第68回日本医学放射線学会学術集会, 横浜, 国内会議

  • 医療における放射線防護の国際動向
    細野 眞, 米矢 吉宏, 村上 卓道
    第68回日本医学放射線学会学術集会, 2009年04月, 第68回日本医学放射線学会学術集会, 横浜, 国内会議

  • 下垂体卒中のMRI所見とその所見の成因機序に関する検討
    下野 太郎, 村上 卓道
    第68回日本医学放射線学会総会, 2009年04月, 第68回日本医学放射線学会総会, 横浜, 下垂体卒中のMRI所見とその所見の成因機序に関する検討した。, 国内会議

  • Optimal Scan Techniques of Dynamic MDCT Imaging for Liver Tumors.
    村上 卓道
    17th Annual Diagnostic Imaging Update on Maui., 2009年03月, 17th Annual Diagnostic Imaging Update on Maui., Maui

  • 多列検出器CTによる三次元臨床画像データを用いた心臓血管解剖講義の試み A trial of a cardiovascular anatomy lecture using three-dimensional clinical imaging by Multi detector-row CT scanner
    工藤正幸, 村上 卓道
    第114回日本解剖学総会・全国学術集会, 2009年03月, 第114回日本解剖学総会・全国学術集会, 岡山

  • Hepatocellular carcinomas with Gd-EOB-DTPA enhanced MRI: Time-intensity analysis from portal dominant phase to hepatobiliary phase.
    岡田 真広, 荒木哲朗, 村上 卓道
    European Congress of Radiology, 2009年03月, European Congress of Radiology, Vienna

  • Gd-EOB-DTPAと肝機能の相関：T2* Mapping法を用いて
    岡田 真広, 村上 卓道
    第20回消化器機能画像研究会, 2009年02月, 第20回消化器機能画像研究会, 大阪

  • 硬化療法の併用が有用であった重症感染症後腸腰筋膿瘍の1例
    朝戸信行, 村上 卓道
    日本IVR学会第25回関西地方会, 2009年02月, 日本IVR学会第25回関西地方会, 大阪

  • 転移性肝腫瘍の検出能における2時間遅延像FDG-PETの検討
    荒木哲朗, 村上 卓道
    第291回日本放射線学会関西地方回, 2009年02月, 第291回日本放射線学会関西地方回, 大阪

  • 診断に苦慮した頚髄pilocytic astrocytomaの１例
    森田敬裕, 下野 太郎, 村上 卓道
    第291回 日本医学放射線学会関西地方会, 2009年02月, 第291回 日本医学放射線学会関西地方会, 大阪, 頸髄pilocytic astrocytomaの1例を解説報告した, 国内会議

  • 肝細胞特異性造影剤の肝細胞癌診断アルゴリズムに与えるインパクト
    村上 卓道
    第28回日本画像医学会, 2009年02月, 第28回日本画像医学会, 東京

  • EOB・プリモビスト造影MRIの最適撮像法と臨床的有用性
    村上 卓道
    第2回広島EOB・プリモビストセミナー, 2009年02月, 第2回広島EOB・プリモビストセミナー, 広島

  • EOB・プリモビスト注の撮像法と有用性
    村上 卓道
    北海道EOB・プリモビストセミナー, 2009年02月, 北海道EOB・プリモビストセミナー, 北海道

  • 腹部MDCT診断：最適撮像法とボリュームデータを用いた4次元画像の有用性
    村上 卓道
    肝臓ダイナミックＣＴセミナー, 2009年02月, 肝臓ダイナミックＣＴセミナー, 金沢

  • Advances in the Diagnosis of HCC: Toward Improved Treatment Decisions.
    村上 卓道
    19th Conference of the Asian Pacific Association for the study of the liver., 2009年02月, 19th Conference of the Asian Pacific Association for the study of the liver., Hong Kong.

  • 肝細胞癌診断におけるGd-EOB-DTPA-MRIの有用性についての検討
    村上 卓道
    第15回肝血流動態イメージ研究会, 2009年01月, 第15回肝血流動態イメージ研究会, 横浜

  • EOB・プリモビスト注の撮像法と肝癌診断におけるインパクト
    村上 卓道
    第2回千葉EOB・プリモビストセミナー, 2009年01月, 第2回千葉EOB・プリモビストセミナー, 千葉

  • Malignant Lymphoma Post Therapy:Usefulness and Pitfalls Using FDG-PET/CT Compared to CT, MRI, and Ga Sxintigraphy.
    岡田 真広, 細野 眞, 村上 卓道
    94rd Radiological Society of North America, 2008年12月, 94rd Radiological Society of North America, Chicago, 国際会議

  • Whole-body MRI with DWI (Diffusion-weighted) for Detecting Metastatic Bone Tumor:Are STIR Images Necessary for Detecting Metastatic Bone Lesions?
    中西 克之, 村上 卓道
    94rd Radiological Society of North America, 2008年12月, 94rd Radiological Society of North America, Chicago, 国際会議

  • How to Use Liver-Spectific Contrast Agents on MRI and Sonography:Enhancement Patterns of Kupffer, Sinusoid, and Hepatocyte Using Superparamagnetic Iron Oxide, Gd-EOB-DTPA, Galactose-Palmitic Acid, and NC100100.
    岡田 真広, 熊野 正士, 村上 卓道
    94rd Radiological Society of North America, 2008年12月, 94rd Radiological Society of North America, Chicago, 国際会議

  • Contrast-enhanced MRI and CT for Biliary System:Advantage and Pitfall of Imaging with Gd-EOB-DTPA and lotroxic Acid Meglumine.
    熊野 正士, 岡田 真広, 村上 卓道
    94rd Radiological Society of North America, 2008年12月, 94rd Radiological Society of North America, Chicago, 国際会議

  • Emergency CT Examination:Important Issues for the Diagnosis of Gastrointestinal Perforation.
    荒木 哲朗, 岡田 真広, 村上 卓道
    94rd Radiological Society of North America, 2008年12月, 94rd Radiological Society of North America, Chicago, 国際会議

  • Is the Use of Lower Tube Voltage (kVp) Useful for Reduction of Patient's Dose for Coronary Artery Calcium Score (CACS) Scanning? Results from Phantom Study.
    工藤 正幸, 村上 卓道
    94rd Radiological Society of North America., 2008年12月, 94rd Radiological Society of North America., Chicago, 国際会議

  • EOB・プリモビスト注の肝癌診断におけるインパクト
    村上 卓道
    九州EOB・プリモビスト講演会, 2008年11月, 九州EOB・プリモビスト講演会, 博多

  • 最近の肝CT・MRI診断の進歩
    村上 卓道
    第7回山梨Body Imaging 研究会, 2008年11月, 第7回山梨Body Imaging 研究会, 甲府, 国内会議

  • 肝細胞がんの診断とカテーテル治療：最新の動向
    村上 卓道
    静岡肝がんフォーラム, 2008年11月, 静岡肝がんフォーラム, 静岡, 国内会議

  • 未来の医療と放射線：腹部画像診断の現状と将来
    村上 卓道
    第19回大阪府放射線技師会学術大会, 2008年11月, 第19回大阪府放射線技師会学術大会, 大阪, 国内会議

  • 64例 MDCT を用いた胃癌深達度診断：Hydro-CTとair filling-CT との比較
    熊野 正士, 桑原 雅知, 村上 卓道
    第290回 日本医学放射線学会関西地方会, 2008年11月, 第290回 日本医学放射線学会関西地方会, 大阪

  • 肝特異性 MRI造影剤 Gd-EOB-DTPA を用いた血流動態解析
    香川祐毅, 岡田 真広, 村上 卓道
    第290回 日本医学放射線学会関西地方会, 2008年11月, 第290回 日本医学放射線学会関西地方会, 大阪

  • シンポジウム12：肝癌診療ガイドラインと診療最前線 肝癌診療におけるGd-EOB-DTPA 造影MRIの有用性
    小来田幸世, 村上 卓道
    第50回日本消化器病学会大会, 2008年10月, 第50回日本消化器病学会大会, 東京

  • 64ch-MDCTによるHelical Scan を用いたWhole Brain CT Perfusion検査の試み
    工藤正幸, 村上 卓道
    第36回日本放射線技術学会秋季学術大会, 2008年10月, 第36回日本放射線技術学会秋季学術大会, 軽井沢

  • Delayed enhancement analysis for small hypervascular hepatocellular carcinomas on Gd-EOB-DTPA enhanced MRI:time-intensity analysis of portal dominant phase and hepatobiliary phase.
    荒木哲朗, 岡田 真広, 村上 卓道
    12th Asia Oceania Congress of Radiology, 2008年10月, 12th Asia Oceania Congress of Radiology, Seoul, 国際会議

  • Quantitative measurement of whole brain CT perfusion parameters and CT angiography using non-stop detector row CT scanner(MDCT) :initial experience.
    工藤 正俊, 村上 卓道
    12th Asia Oceania Congress of Radiology, 2008年10月, 12th Asia Oceania Congress of Radiology, Seoul, 国際会議

  • T-staging of gastric cancer of air-filling multidetector-row CT:comparison with hydro-multidetector-row CT.
    熊野 正士, 岡田 真広, 村上 卓道
    12th Asia Oceania Congress of Radiology, 2008年10月, 12th Asia Oceania Congress of Radiology, Seoul, 国際会議

  • T staging of stomach cancer:CT and MR imaging.
    村上 卓道
    12th Asia Oceania Congress of Radiology, 2008年10月, 12th Asia Oceania Congress of Radiology, Seoul, 国際会議

  • Dynamic MDCT of hepatocellular carcinoma.
    村上 卓道
    12th Asia Oceania Congress of Radiology, 2008年10月, 12th Asia Oceania Congress of Radiology, Seoul, 国際会議

  • OOKP(歯根部利用人工角膜)手術後のCT像
    桑原 雅知, 下野 太郎, 勝部 敬, 藤谷 哲也, 松久保 祐子, 足利 竜一朗, 福田 昌彦, 濱田 傑, 細野 眞, 村上 卓道
    第44回日本医学放射線学会秋季臨床大会, 2008年10月, 第44回日本医学放射線学会秋季臨床大会, 福島, 国内会議

  • 最新の肝のMDCT・MRI診断
    村上 卓道
    第33回大阪肝臓を語る会, 2008年10月, 第33回大阪肝臓を語る会, 大阪, 国内会議

  • Primovist-enhanced MRI of HCC in cirrhotic and non-cirrhotic patients: Optimized protocol conditions and comparison to other modalities.
    村上 卓道
    The seventh Bayer Schering Pharma AG International Advisory Board Meeting., 2008年10月, The seventh Bayer Schering Pharma AG International Advisory Board Meeting., Kyoto, 国内会議

  • Impact of Primovist on current diagnpostic and therapeutic algorithms in HCC.
    村上 卓道
    The second international Forum for Liver MRI 2008, 2008年10月, The second international Forum for Liver MRI 2008, Kyoto, 国内会議

  • 卵巣内膜症性嚢胞に認めた結節が自然経過にて消失した一例
    香川祐毅, 村上 卓道
    第9回JSAWI, 2008年09月, 第9回JSAWI, 淡路

  • MR imaging of the liver lesion.
    村上 卓道
    Visions for the feature of MRI, 2008年09月, Visions for the feature of MRI, Berlin, 国際会議

  • IRパルス付近3D B-TEF法を用いたEOB・Primovist造影後期相における胆管抽出の検討
    中塚隆之, 西松和彦, 村上 卓道
    第36回日本磁気共鳴医学会大会 2008年9月, 2008年09月, 第36回日本磁気共鳴医学会大会 2008年9月, 旭川, 国内会議

  • 副所見を含めて考える卵巣癌の組織分類
    安藤理奈, 今岡 いずみ, 村上 卓道
    第36回日本磁気共鳴医学会大会, 2008年09月, 第36回日本磁気共鳴医学会大会, 旭川, 国内会議

  • 子宮Junctional zone (JZ) を含めた子宮筋層と心筋収縮の比較
    荒木哲朗, 今岡 いずみ, 村上 卓道
    第36回日本磁気共鳴医学会大会, 2008年09月, 第36回日本磁気共鳴医学会大会, 旭川, 国内会議

  • EOB・プリモビスト造影MRIの至適撮像タイミングと臨床的有用性
    村上 卓道
    第36回日本磁気共鳴医学会大会, 2008年09月, 第36回日本磁気共鳴医学会大会, 旭川市, 国内会議

  • GD-EOB-DTPAによる多血性HCC動脈血流解析：Gd-DTPAとの比較も含めて
    岡田 真広, 香川祐毅, 村上 卓道
    第36回日本磁気共鳴医学会大会, 2008年09月, 第36回日本磁気共鳴医学会大会, 旭川, 国内会議

  • Optimal Scan Technique and New Imaging Technique of MDCT of the Liver Tumor
    村上 卓道
    Invited lecture in University of Chicago, 2008年08月, Invited lecture in University of Chicago, Chicago, 国際会議

  • EOB・プリモビスト造影剤MRIの特徴と期待
    村上 卓道
    第49回日本消化器画像診断研究会, 2008年08月, 第49回日本消化器画像診断研究会, 東大阪

  • 肝癌の診断と治療：画像診断とカテーテル治療
    村上 卓道
    日本肝臓学会平成20年度肝癌撲滅運動市民公開講座, 2008年08月, 日本肝臓学会平成20年度肝癌撲滅運動市民公開講座, 大阪狭山市

  • EOB・プリモビスト造影MRIの特徴と臨床的有用性
    村上 卓道
    第24回放射線技師総合学術大会, 2008年07月, 第24回放射線技師総合学術大会, 札幌

  • 腹部先端画像診断：CT, PETなど
    村上 卓道
    第3回医療連携ネットワークカンファレンス, 2008年07月, 第3回医療連携ネットワークカンファレンス, 大阪

  • EOB・プリモビスト造影MRIの特徴と期待
    村上 卓道
    第5回山口MRI Update, 2008年06月, 第5回山口MRI Update, 宇部, 国内会議

  • Adrenal masses: The additional value of FDG-PET/CT for cancer patients.
    岡田 真広, 細野 眞, 村上 卓道
    55th annual meeting of Society of Nuclear Medicine, 2008年06月, 55th annual meeting of Society of Nuclear Medicine, New Orleans, 国際会議

  • Utility of partial volume correction based on count recovery on FDG PET/CT in lymph node metastasis of lung cancer
    米矢 吉宏, 細野 眞, 村上 卓道
    55th annual meeting of Society of Nuclear Medicine, 2008年06月, 55th annual meeting of Society of Nuclear Medicine, New Orleans, 国際会議

  • New insight into the pathogenesis of malignant lymphoma by integrated FDG-PET/CT
    岡田 真広, 細野 眞, 村上 卓道
    55th annual meeting of Society of Nuclear Medicine, 2008年06月, 55th annual meeting of Society of Nuclear Medicine, New Orleans, 国際会議

  • Evaluation of lymph node metastases in esophageal cancer with SUV correction for partial volume effect on FDG PET/CT
    香川祐毅, 細野 眞, 村上 卓道
    55th annual meeting of Society of Nuclear Medicine, 2008年06月, 55th annual meeting of Society of Nuclear Medicine, New Orleans, 国際会議

  • 肝癌治療におけるCone beam CTの有用性
    柳生行伸, 桑原 雅知, 村上 卓道
    第８回関西肝血流動態イメージ研究会, 2008年06月, 第８回関西肝血流動態イメージ研究会, 大阪, 国内会議

  • 肝特異性MRI造影剤Gd-EOB-DTPAを用いた多血性HCCの血流動態
    岡田 真広, 香川祐毅, 村上 卓道
    第８回関西肝血流動態イメージ研究会, 2008年06月, 第８回関西肝血流動態イメージ研究会, 大阪, 国内会議

  • 婦人科疾患のMRI診断
    村上 卓道
    第100回山形県産婦人科集談会, 2008年06月, 第100回山形県産婦人科集談会, 山形

  • 主膵管との交通を有したため術前診断が困難であった膵内分泌腫瘍の一例
    香川祐毅, 桑原 雅知, 村上 卓道
    第22回腹部放射線研究会, 2008年06月, 第22回腹部放射線研究会, つくば

  • MRI T2強調画像にて低信号を呈した卵巣粘液嚢胞腺癌の一例
    桑原 雅知, 今岡 いずみ, 村上 卓道
    第22回腹部放射線研究会, 2008年06月, 第22回腹部放射線研究会, つくば

  • 肝腫瘍診断におけるEOB・プリモビスト造影MRI
    村上 卓道
    第一回関西EOB・プリモビストセミナー, 2008年06月, 第一回関西EOB・プリモビストセミナー, 大阪

  • MDCT, MRI画像診断によるHCCのRFA治療効果判定
    岡田 真広, 熊野 正士, 村上 卓道
    第44回日本肝癌研究会, 2008年05月, 第44回日本肝癌研究会, 大阪

  • 腹部領域における64列MDCTの有用性
    村上 卓道
    第18回青葉画像研究会, 2008年05月, 第18回青葉画像研究会, 仙台市, 国内会議

  • Clinical utility of 4D volumetric data of MDCT for upper abdominal disease.
    村上 卓道
    The 10th annual international symposium on multidetector-row CT., 2008年05月, The 10th annual international symposium on multidetector-row CT., Las Vegas

  • Optimal scan technique of early and late arterial phase MDCT imaging of the liver tumor.
    村上 卓道
    The 10th annual international symposium on multidetector-row CT., 2008年05月, The 10th annual international symposium on multidetector-row CT., Las Vegas., 国際会議

  • 64ch-MDCTによるHelical Scanを用いたWhole Brain CT Perfusion検査の試み
    工藤正幸, 村上 卓道
    第64回日本放射線技術学会学術大会, 2008年04月, 第64回日本放射線技術学会学術大会

  • Scan timing of EOB-Primovist dynamic MRI of the Liver.
    村上 卓道
    Bayer Schering Pharma AG International Advisory Board Meeting., 2008年04月, Bayer Schering Pharma AG International Advisory Board Meeting., Milan, 国際会議

  • EOB・プリモビスト造影MRIの特徴と期待
    村上 卓道
    第一回北陸EOB・プリモビストセミナー, 2008年04月, 第一回北陸EOB・プリモビストセミナー, 金沢, 国内会議

  • 原発性肺癌のリンパ節転移の評価におけるrecovery coefficient(RC)－SUV補正の有用性
    米矢 吉宏, 細野 眞, 村上 卓道
    第67回日本医学放射線学学術集会, 2008年04月, 第67回日本医学放射線学学術集会, 横浜

  • 3TMRIによる子宮体癌のT2強調像：1.5Tとの比較
    堀 雅敏, 今岡 いずみ, 村上 卓道, 金 東石
    第67回日本医学放射線学会学術集会, 2008年04月, 第67回日本医学放射線学会学術集会, 横浜

  • 側脳室内壁付着結節：これ、何ですか？
    下野 太郎, 足利 竜一朗, 村上 卓道
    第67回日本医学放射線学会学術集会, 2008年04月, 第67回日本医学放射線学会学術集会, 横浜

  • T2＊fitting toolによる子宮筋腫と子宮良性病変の評価
    今岡 いずみ, 柳生行伸, 村上 卓道, 奥秋知幸, 小
    第67回日本医学放射線学会学術集会, 2008年04月, 第67回日本医学放射線学会学術集会, 横浜

  • リポソーム化造影剤による動物モデルの肝臓腫瘍造影研究
    荒木哲朗, 岡田 真広, 村上 卓道, 大西裕満, 磯田武寿
    第67回日本医学放射線学会学術集会, 2008年04月, 第67回日本医学放射線学会学術集会, 横浜

  • ガドニウム造影多時相ダイナミック検査による肝臓シネMRIの初期検討
    熊野 正士, 岡田 真広, 村上 卓道, 奥秋知幸, 小山
    第67回日本医学放射線学会学術集会, 2008年04月, 第67回日本医学放射線学会学術集会, 横浜

  • アンケート方式による肝特異性造影剤フェルカルボトラン(リゾビスト)の安全調査
    大西裕満, 村上 卓道, 金東石
    第67回日本医学放射線学会学術集会, 2008年04月, 第67回日本医学放射線学会学術集会, 横浜

  • 悪性リンパ腫のPET-CTとMRI診断
    岡田 真広, 下野 太郎, 村上 卓道, 佐藤範英
    第67回日本医学放射線学会学術集会, 2008年04月, 第67回日本医学放射線学会学術集会, 横浜

  • 食道癌リンパ節のPET/CTによる評価
    岡田 真広, 細野 眞, 村上 卓道
    第108回核医学症例検討会, 2008年02月, 第108回核医学症例検討会, 大阪, 国内会議

  • 悪性リンパ腫のPET-CT診断に関するReview
    岡田 真広, 細野 眞, 村上 卓道
    第27回日本画像医学会, 2008年02月, 第27回日本画像医学会, 東京, 国内会議

  • 子宮頸癌再発による外腸骨動脈?S状結腸瘻の一例
    松久保祐子, 柳生行伸, 村上 卓道
    第24回中部・第23回関西合同地方会（第44回関西IVR研究会）, 2008年02月, 第24回中部・第23回関西合同地方会（第44回関西IVR研究会）, 大阪, 国内会議

  • TACE術前にHelical Shuttle scanを施行した一例
    柳生行伸, 熊野 正士, 村上 卓道
    第19回消化器機能画像研究会, 2008年02月, 第19回消化器機能画像研究会, 大阪, 国内会議

  • EOB・プリモビストによって肝画像診断はどう変わっていくか？
    村上 卓道
    第27回日本画像医学会, 2008年02月, 第27回日本画像医学会, 東京

  • 診断に苦慮したependymomaの2例
    荒木 哲朗, 下野 太郎, 村上 卓道
    第288回 日本医学放射線学会関西地方会, 2008年02月, 第288回 日本医学放射線学会関西地方会, 大阪

  • Whole Body MRI with Diffeusion-weighted Image for Detecting Skeletal,Lymph Nodal, and Other Incidental Lesions.
    中西 克之, 村上 卓道, 小林 美登利
    93rd Radiologocal Society of North America, 2007年12月, 93rd Radiologocal Society of North America, Chicago, 国際会議

  • 肝臓MRI診断の最前線：新しい肝特異性MR造影剤は画像診断をいかに変えるか
    村上 卓道
    第8回国際造影超音波シンポジウム, 2007年12月, 第8回国際造影超音波シンポジウム, 大阪, 国内会議

  • 造影後期MRIとFDG-PETで早期診断と治療効果判定を評価した心サルコイドーシスの一例
    武輪光彦, 谷口 貢, 村上 卓道
    第104回日本循環器学会近畿地方会, 2007年12月, 第104回日本循環器学会近畿地方会, 京都

  • Development of Dynamic Pitch Helical Reconstruction Algorithm for Continuous Helical Shuttle Scan of 64ch MDCT with Advanced Table Control.
    萩原明, 工藤 正俊, 村上 卓道, 柳生行伸
    93rd Radiological Society of North America, 2007年12月, 93rd Radiological Society of North America, Chicago, 国際会議

  • Recovery Coefficoent(RC)に基づくSUV補正用いた肺癌リンパ節転移の評価
    米矢 吉宏, 細野 眞, 村上 卓道
    第47回日本核医学会学術総会, 2007年11月, 第47回日本核医学会学術総会, 仙台, 国内会議

  • 新しい肝特異性MR造影剤
    村上 卓道
    RSNA2007後援会, 2007年11月, RSNA2007後援会, シカゴ, 国際会議

  • Wide Spectrum of Malignant Lymphoma:New Insight into the Pathogenesis of Lymphoid Malignancies in PET-CT and MRI.
    岡田 真広, 米矢 吉宏, 村上 卓道
    93rd Radiological Society of North America, 2007年11月, 93rd Radiological Society of North America, Chicago, 国際会議

  • Comparison of integrated FDG-PET/CT with IV-contrast enhanced CT for the evalution of metastatic regional lymph nodes in esophageal cancer patients.
    岡田 真広, 桑原 雅知, 村上 卓道
    93rd Radiological Society of North America, 2007年11月, 93rd Radiological Society of North America, Chicago, 国際会議

  • T-staging og Gastric Cancer of Air-filling Multi-detector Row CT:Vomparison with Hydro-Multidetector Row CT.
    熊野 正士, 桑原 雅知, 村上 卓道
    93rd Radiologocal Society of North America, 2007年11月, 93rd Radiologocal Society of North America, Chicago, 国際会議

  • MR Cholangiopancreatography at 3.0 T:Intraindividual Comparative Studu with MR Cholangiopancreatography at 1.5 T.
    大西 裕満, 村上 卓道, 金 東石
    93rd Radiological Society of North America, 2007年11月, 93rd Radiological Society of North America, Chicago, 国際会議

  • 腹部の造影MDCT診断：ボリュームデータの有用性
    村上 卓道
    第58回香川画像診断談話会, 2007年11月, 第58回香川画像診断談話会, 国内会議

  • 腹部領域における64列MDCTの有用性
    村上 卓道
    第43回日本医学放射線学会秋季臨床大会, 2007年10月, 第43回日本医学放射線学会秋季臨床大会, 名古屋, 国内会議

  • 消化管奇形を伴ったミュラー管形成異常の画像所見
    香川 祐毅, 今岡 いずみ, 村上 卓道
    ＪＳＡＷ, 2007年09月, ＪＳＡＷ, 淡路, 国内会議

  • 3テスラMRIにおける肝腫瘤性病変のコントラスト：1.5テスラMRIとの比較
    大西 裕満, 村上 卓道, 金 東石
    第35回日本磁気共鳴医学会, 2007年09月, 第35回日本磁気共鳴医学会, 神戸, 国内会議

  • 3T 1MRIによる子宮癌のT2強調像：1.5Tとの比較
    堀 雅敏, 村上 卓道, 金 東石
    第35回日本磁気共鳴医学会, 2007年09月, 第35回日本磁気共鳴医学会, 神戸, 国内会議

  • Gd-EOB-DTPA造影MRIにおけるNASH肝線維化評価：NASH staging
    津田奈津子, 岡田 真広, 村上 卓道
    第35回日本磁気共鳴医学会, 2007年09月, 第35回日本磁気共鳴医学会, 神戸, 国内会議

  • 拡散強調像を用いた全身MRI
    中西 克之, 村上 卓道, 小林美登利
    第35回日本磁気共鳴医学会, 2007年09月, 第35回日本磁気共鳴医学会, 神戸, 国内会議

  • 3D-PRESTOを用いた高分解能MR Vnographyの検討
    坪山尚寛, 今岡 いずみ, 中塚隆之, 村上 卓道, 松本光代, 奥秋智幸, 小山望
    日本磁気共鳴医学会, 2007年09月, 日本磁気共鳴医学会, 神戸, 国内会議

  • PRESTOを用いた深部脳静脈の描出の検討
    中塚隆之, 坪山尚寛, 今岡 いずみ, 村上 卓道, 奥秋智幸, 小山望, 松本光代
    日本磁気共鳴医学会, 2007年09月, 日本磁気共鳴医学会, 神戸, 国内会議

  • T2* fitting toolによる子宮筋層評価
    今岡 いずみ, 中塚隆之, 坪山尚寛, 村上 卓道, 松本光代, 奥秋智幸, 小山望
    日本磁気共鳴医学会, 2007年09月, 日本磁気共鳴医学会, 神戸

  • 遅延造影MRIとFDG-PETで評価した心サルコイドーシスの一例
    芦澤憲太郎, 武輪光彦, 村上 卓道
    第24回循環器内科・外科フォーラム, 2007年09月, 第24回循環器内科・外科フォーラム, 大阪

  • 肝癌の画像診断とカテーテル治療
    村上 卓道
    日本肝臓学会平成19年度肝癌撲滅運動市民公開講座, 2007年09月, 日本肝臓学会平成19年度肝癌撲滅運動市民公開講座, 堺市

  • 腹部の造影MDCTの最適撮像法を中心に
    村上 卓道
    奈良CT conference, 2007年09月, 奈良CT conference, 奈良

  • 腎癌摘出後14年目に生じた膵転移に対してPET-CTとDynamic CTを施行した一例 腎癌の遠隔転移におけるPET-CTの役割
    松久保祐子, 岡田 真広, 村上 卓道
    第107会核医学会症例検討会, 2007年08月, 第107会核医学会症例検討会, 大阪, 国内会議

  • 無水エタノールによる腎動脈塞栓術が著効した低形成腎による腎性高血圧の1女児例
    田端 信忠, 伊豆 亜加音, 井上 智弘, 篠原 徹, 任 誠雲, 坪山 尚寛, 栁生 行伸, 村上 卓道, 竹村 司
    第14回小児高血圧研究会, 2007年08月, 第14回小児高血圧研究会, 慶應義塾大学（東京都）, 国内会議

  • 肝特異性MRI造影GD-EOB-DTPAによるNASHと脂肪肝の鑑別診断の可能性
    岡田 真広, 村上 卓道, 津田奈津子
    第7回関西肝血流動態イメージ研究会, 2007年07月, 第7回関西肝血流動態イメージ研究会, 大阪, 国内会議

  • 腹部のMRI診断
    村上 卓道
    堺市医師会外科医会学術講演会, 2007年07月, 堺市医師会外科医会学術講演会, 大阪

  • 消化器疾患の最新のMDCT
    村上 卓道
    伊丹市医師会第４回消化器勉強会, 2007年07月, 伊丹市医師会第４回消化器勉強会, 伊丹

  • 腹部の造影MDCT：最適撮像法とvolume dataの有用性
    村上 卓道
    放射線診療フォーラム, 2007年07月, 放射線診療フォーラム, 福岡

  • Hepatocellular carcinoma by multimodality imaging:MSCT,US,MRI and PET.
    岡田 真広, 熊野 正士, 村上 卓道
    18 th annual Meeting ESGAR 2007, 2007年06月, 18 th annual Meeting ESGAR 2007, Lisbon, Portugal, 国際会議

  • 肝癌に対する画像診断アルゴリズムの構築：多血性および乏血性肝細胞癌の画像診断のアルゴリズム
    小来田幸世, 村上 卓道, 今井康陽
    第４３回日本肝癌研究会, 2007年06月, 第４３回日本肝癌研究会, 東京, 国内会議

  • 肝癌に対する画像診断アルゴリズムの構築：多血性および乏血性肝細
    小来田幸世, 村上 卓道
    第４３回日本肝癌研究会, 2007年06月, 第４３回日本肝癌研究会, 東京

  • 腹部MDCTの最適撮像法とその臨床的有用性
    村上 卓道
    第51回島根画像診断研究会, 2007年06月, 第51回島根画像診断研究会, 出雲

  • 経過中に間質肉腫への悪性転化が疑われた前立腺 cysticepithelial-stromaltumorの一例
    荒木哲朗, 桑原 雅知, 村上 卓道
    第289回日本医学放射線学会関西地方会（第358回レントゲンアーベント）, 2007年06月, 第289回日本医学放射線学会関西地方会（第358回レントゲンアーベント）, 国内会議

  • 前立腺 cystic epithelial-stromal tumor とその再発巣の悪性転化の一例
    荒木哲朗, 桑原 雅知, 村上 卓道
    第21回腹部放射線研究会, 2007年06月, 第21回腹部放射線研究会, 宮崎, 国内会議

  • Effect of attenuation correction on wall motion quantification in Tl-201 ECG-gated myocardial SPECT. Assessment of lymph node metastasis in lung cancer with SUV correction based on count recovery in FDG PET/CT.
    細野 眞, 米矢 吉宏, 村上 卓道
    54th Annual Meeting of Society of Nuclear Medicine., 2007年06月, 54th Annual Meeting of Society of Nuclear Medicine., Washington DC., 国際会議

  • Assessment of lymph node metastasis in lung cancer with SUV correction based on count recovery in FDG PET/CT.
    米矢 吉宏, 細野 眞, 村上 卓道
    54th Annual Meeting of Society of Nuclear Medicine., 2007年06月, 54th Annual Meeting of Society of Nuclear Medicine., Washington DC., 国際会議

  • Optimization of 3D-PRESTO (principles of echo shifting with a train of observations)sequence for T2* sensitized high-resolution MR venography.
    中塚隆之, 坪山 尚寛, 今岡 いずみ, 下野 太郎, 村上 卓道, 蟇目, 福島, 奥秋智幸, 小山望, 松本光代
    ISMRM, 2007年05月, ISMRM, Berlin, 国際会議

  • Assessment of the Uterine Myometrium Using T2* Relaxometry with a Correction of Magnetic Filed Inhomogeneity
    今岡 いずみ, 中塚隆之, 村上 卓道
    JOINT ANNUAL MEETING ISMRM-ESMRMB, 2007年05月, JOINT ANNUAL MEETING ISMRM-ESMRMB, BERLIN,GERMANY, 国際会議

  • MR Cholangiopancreatography at 3.0 T:Intraindividual Comparative Study with MR Cholangiopancreatography at 1.5 T
    大西裕満, 村上 卓道, 金東石
    JOINT ANNUAL MEETING ISMRM-ESMRMB, 2007年05月, JOINT ANNUAL MEETING ISMRM-ESMRMB, BERLIN,GERMANY, 国際会議

  • Potential of Gd-EOB-DAPA for Differential Diagnosis of Nonalcoholic Steatohepatitis and Fatty Liver in Rats Using Magnetic Resonance Imaging
    津田奈津子, 村上 卓道
    OINT ANNUAL MEETING ISMRM-ESMRMB, 2007年05月, OINT ANNUAL MEETING ISMRM-ESMRMB, BERLIN,GERMANY, 国際会議

  • T2* Sensitized High Resolution MR Venography Using 3D-PRESTO(Principles of Echo Shifting with a Train of Observations)
    坪山 尚寛, 今岡 いずみ, 村上 卓道
    JOINT ANNUAL MEETING ISMRM-ESMRMB, 2007年05月, JOINT ANNUAL MEETING ISMRM-ESMRMB, BERLIN,GERMANY, 国際会議

  • Calcifications as Clue to Diagnosis in Abdominal Diseases : Effectiveness of CT and MRI
    任誠雲, 岡田 真広, 村上 卓道
    第66回日本医学放射線学会学術集会, 2007年04月, 第66回日本医学放射線学会学術集会, 横浜, 国内会議

  • Utility of MRI,CT and PET for Peritoneal Dissemination and Abdominal Wall Metastasis
    米矢 吉宏, 岡田 真広, 村上 卓道, 松村要
    2007年04月, 国内会議

  • 悪性リンパ腫のPET-CT診断
    岡田 真広, 細野 眞, 村上 卓道, 竹内亮, 佐藤範英
    第66回日本医学放射線学会学術集会, 2007年04月, 第66回日本医学放射線学会学術集会, 横浜, 国内会議

  • MRCP用経口消化管陰性造影剤ボースデルの３テスラ環境における至適濃度の検討
    大西裕満, 村上 卓道, 金東石
    第66回日本医学放射線学会学術集会, 2007年04月, 第66回日本医学放射線学会学術集会, 横浜, 国内会議

  • 3テスラ装置におけるMRCPの画質評価：1.5テスラ装置との比較
    大西裕満, 村上 卓道, 金東石
    第66回日本医学放射線学会学術集会, 2007年04月, 第66回日本医学放射線学会学術集会, 横浜, 国内会議

  • 骨盤部の3T MRI：T2強調FSE撮影パラメーターの最適化
    堀雅敏, 村上 卓道, 金東石
    第66回日本医学放射線学会学術集会, 2007年04月, 第66回日本医学放射線学会学術集会, 横浜, 国内会議

  • クロイツフェルト・ヤコブ病(CJD)のMRI診断において詳細な読影をする前に可能性を想起できるか？
    下野 太郎, 坪山 尚寛, 村上 卓道
    第66回日本医学放射線学会学術集会, 2007年04月, 第66回日本医学放射線学会学術集会, 横浜, 国内会議

  • フェルカルボトラン造影MRIにおけるT1強調像撮影タイミングについての検討
    熊野 正士, 村上 卓道, 平田雅昭
    第66回日本医学放射線学会学術集会, 2007年04月, 第66回日本医学放射線学会学術集会, 横浜, 国内会議

  • T2※強調gradient echo MRIにおける肝腫瘍のコントラストに対するSPIOの影響：3.0Tと1.5Tの比較
    金東石, 村上 卓道, 堀雅敏
    第66回日本医学放射線学会学術集会, 2007年04月, 第66回日本医学放射線学会学術集会, 横浜, 国内会議

  • The New Myocardial Perfusion Imaging using 64-slice Multi Detector Computed Tomography.
    中内 祥文, 生田 新一郎, 村上 卓道
    71st Annual Scientific Meeting of the Japanese Circulation Society., 2007年03月, 71st Annual Scientific Meeting of the Japanese Circulation Society., Kobe, 国内会議

  • 腎血管性高血圧患者に対して腎動脈塞栓術が著効した一例
    任誠雲, 足利 竜一朗, 村上 卓道
    日本ＩＮＴＥＲＶＥＮＴＩＯＮＡＬ ＲＡＤＩＯＬＯＧＹ学会 第21回関西地方会（第42回関西ＩＮＴＥＲＶＥＮＴＩＯＮＡＬ ＲＡＤＩＯＬＯＧＹ研究会）, 2007年02月, 日本ＩＮＴＥＲＶＥＮＴＩＯＮＡＬ ＲＡＤＩＯＬＯＧＹ学会 第21回関西地方会（第42回関西ＩＮＴＥＲＶＥＮＴＩＯＮＡＬ ＲＡＤＩＯＬＯＧＹ研究会）, 大阪, 国内会議

  • ヘリカルシャトルスキャンによるボリュームスキャン
    柳生行伸, 村上 卓道, 金東石
    第18回 消化器機能画像研究会, 2007年02月, 第18回 消化器機能画像研究会, 大阪

  • 肝癌のCT,MRI診断
    村上 卓道
    第40回福井肝癌研究会, 2007年02月, 第40回福井肝癌研究会, 福井

  • MDCTによる画像診断
    村上 卓道
    第52回鳥取県東部医師会医学セミナー, 2007年02月, 第52回鳥取県東部医師会医学セミナー, 鳥取

  • 肝のMDCT診断
    村上 卓道
    第1回大阪肝臓病ワークショップ, 2007年, 第1回大阪肝臓病ワークショップ, 大阪

  • T2-Weighted MR Imaging of the Pelvis at 3.0 Tesla:Optimum Routine Fast Spin-Echo Sequencec
    堀雅敏, 村上 卓道, 金東石
    JOINT ANNUAL MEETING ISMRM-ESMRMB, 2007年, JOINT ANNUAL MEETING ISMRM-ESMRMB, BERLIN,GERMANY, 国際会議

  • 腹部の造影MDCT：最適撮像法とvolume dataの有用性
    村上 卓道
    放射線診療学術講演会, 2007年, 放射線診療学術講演会, 大阪

  • 卵巣腫瘤との鑑別が困難であった限局性腹膜偽粘液腫の一例
    清水利栄, 今岡 いずみ, 下野 太郎, 桑原 雅知, 小塚 健倫, 葉輝明, 坪山 尚寛, 柳生行伸, 熊野 正士, 足利 竜一朗, 村上 卓道, 米矢 吉宏, 土屋 典生, 岡田 真広, 細野 眞
    日本医学放射線学会関西地方会, 2006年11月, 日本医学放射線学会関西地方会, 国内会議

  • MR Imaging of the pelvis at 3.0 tesla : How to do it.
    堀雅敏, 村上 卓道, 金東石
    92nd Radiological Society of North America., 2006年11月, 92nd Radiological Society of North America., Chicago., 国際会議

  • PET first : Malignant Lymphoma.
    岡田 真広, 細野 眞, 村上 卓道, 竹内亮, 佐藤範英
    92nd Radiological Society of North America., 2006年11月, 92nd Radiological Society of North America., Chicago., 国際会議

  • Whole-body MRI with using diffusion-weighted whole-body images with background suppression (DWIBS) for detecting metastatic bone tumor : comparison with bone scintigram (BS).
    Nakanishi K, 村上 卓道, Kobayashi M
    92nd Radiological Society of North America., 2006年11月, 92nd Radiological Society of North America., Chicago., 国際会議

  • Abdominal calcifications : Pictorial review of liver, spleen, gallbladder, kidney, peritoneum, and vascular structure lesions.
    任誠雲, 岡田 真広, 村上 卓道
    92nd Radiological Society of North America., 2006年11月, 92nd Radiological Society of North America., Chicago., 国際会議

  • MR Imaging, CT, and PET in patients with cancer of peritoneum and abdominal wall.
    米矢 吉宏, 岡田 真広, 村上 卓道
    92nd Radiological Society of North America., 2006年11月, 92nd Radiological Society of North America., Chicago., 国際会議

  • Optimal scanning protocol of 3 tesla MR imaging for the upper abdominal diseases.
    大西裕満, 村上 卓道, 金東石
    92nd Radiological Society of North America., 2006年11月, 92nd Radiological Society of North America., Chicago., 国際会議

  • Multidetector-Row CT of the liver : Optimal imaging protocol.
    堀雅敏, 村上 卓道
    92nd Radiological Society of North America., 2006年11月, 92nd Radiological Society of North America., Chicago., 国際会議

  • Biliary obstruction : Value of imaging for choledocholithiasis, pancreas, and bile duct cancer.
    岡田 真広, 任誠雲, 村上 卓道
    92nd Radiological Society of North America, 2006年11月, 92nd Radiological Society of North America, Chicago., 国際会議

  • Hepatocellular carcinoma, cholangiocarcinoma, and liver metastasis by multimodality imaging : MSCT, US, MRI, and PET.
    岡田 真広, 柳生行伸, 村上 卓道
    92nd Radiological Society of North America., 2006年11月, 92nd Radiological Society of North America., Chicago., 国際会議

  • MR Imaging of the upper abdomen at 3 tesla: Comparison with imaging at 1.5 tesla.
    大西裕満, 村上 卓道
    92nd Radiological Society of North America., 2006年11月, 92nd Radiological Society of North America., Chicago., 国際会議

  • Diagnosis of recurrence of gastrointestinal stromal tumor after treatment with imatinib mesylate by using MDCT and FDG-PET.
    金東石, 坪山 尚寛, 村上 卓道
    92nd Radiological Society of North America., 2006年11月, 92nd Radiological Society of North America., Chicago., 国際会議

  • Assessment of 4D MDCT abdominal angiography by using non-stop continuous helical shuttle scan technique.
    工藤 正俊, 村上 卓道
    92nd Radiological Society of North America., 2006年11月, 92nd Radiological Society of North America., Chicago., 国際会議

  • Image-guided Radioltherapy:現状と将来, 肝癌の描出と肝機能診断 ?最新のMDCTとMRI-
    村上 卓道
    日本放射線腫瘍学会第19回学術大会, 2006年11月, 日本放射線腫瘍学会第19回学術大会, 仙台

  • 16列から64列MDCTにおける腹部疾患の最適撮像法と臨床応用
    村上 卓道
    第10回東部放射線研究会, 2006年11月, 第10回東部放射線研究会, 福山, 国内会議

  • Pulmonary hyalinizing granulomaが強く疑われMalignant mesotheliomaを合併した一例：FDG－PET/CTによる良悪性の検討
    岡田 真広, 細野 眞, 村上 卓道, 松村要
    第4２回日本医学放射線学会秋季臨床大会, 2006年10月, 第4２回日本医学放射線学会秋季臨床大会, 福岡, 国内会議

  • 腹部の最新MDCT診断
    村上 卓道
    第14回いわき腹部画像研究会, 2006年10月, 第14回いわき腹部画像研究会, いわき市, 国内会議

  • 肝臓dynamic CTにおける至適造影法
    村上 卓道
    第42回日本医学放射線学会秋季大会, 2006年10月, 第42回日本医学放射線学会秋季大会, 福岡, 国内会議

  • 64 channel MDCT of upper abdomen: Optimal scan technique and clinical utility.
    村上 卓道
    Invited lecture in Seoul National University College of Medicine., 2006年09月, Invited lecture in Seoul National University College of Medicine., Seoul., 国際会議

  • CT and MR staging of gastric cancer
    村上 卓道
    The 16th International Seoul Radiology Symposium: CT colonography & Update in Gastrointestinal Imagi, 2006年09月, The 16th International Seoul Radiology Symposium: CT colonography & Update in Gastrointestinal Imagi, Seoul, 国際会議

  • 消化器疾患のMDCT診断
    村上 卓道
    85回日本消化器病学会近畿支部例会, 2006年09月, 85回日本消化器病学会近畿支部例会, 大阪, 国内会議

  • MDCTにおける腹部疾患の３次元画像診断
    村上 卓道
    第48回滋賀肝疾患研究会, 2006年09月, 第48回滋賀肝疾患研究会, 草津, 国内会議

  • 腹部領域におけるMDCTの撮像法と臨床応用
    村上 卓道
    第17回徳島CT研究会, 2006年09月, 第17回徳島CT研究会, 徳島, 国内会議

  • 放射線医学とCT
    村上 卓道
    臨床医工学・情報学スキルアップ講座 高度診断治療コース 医用画像情報学, 2006年08月, 臨床医工学・情報学スキルアップ講座 高度診断治療コース 医用画像情報学, 大阪

  • 肝門部胆管癌術後に生じた門脈狭窄に対して門脈ステント留置を行った1例
    児玉 彩, 柳生 行伸, 村上 卓道
    第20回関西地方会（第41回関西IVR研究会）, 2006年07月, 第20回関西地方会（第41回関西IVR研究会）, 大阪, 国内会議

  • 進行肝癌に対するIFN併用化学療法の有用性に関する多施設共同研究－厚労科研（肝炎対策研究事業）－
    永野浩明, 村上 卓道
    第４２回日本肝癌研究会, 2006年07月, 第４２回日本肝癌研究会, 東京, 国内会議

  • Real-time Virtual Sonography(RVS)ガイド下ラジオ波焼灼療法の有用性についての検討
    北田学利, 村上 卓道, 葛下典由
    第４２回日本肝癌研究会, 2006年07月, 第４２回日本肝癌研究会, 東京, 国内会議

  • MDCTにおける腹部疾患の３次元画像診断
    村上 卓道
    第14回東神戸消化器疾患セミナー, 2006年07月, 第14回東神戸消化器疾患セミナー, 神戸, 国内会議

  • 早期肝癌における血流動態とSPIO造影MRIの造影効果
    村上 卓道, 今井康陽, 堀 雅敏
    第４２回日本肝癌研究会, 2006年07月, 第４２回日本肝癌研究会, 東京, 国内会議

  • 64列MDCTにおける腹部領域の最適撮像法と臨床応用
    村上 卓道
    第5回近畿MDCT技術・診断研究会, 2006年07月, 第5回近畿MDCT技術・診断研究会, 大阪, 国内会議

  • 肝胆膵疾患のインターベンショナルラジオロジー（IVR)
    村上 卓道
    第13回南大阪肝胆膵懇話会, 2006年07月, 第13回南大阪肝胆膵懇話会, 大阪, 国内会議

  • 腹部MDCT診断
    村上 卓道
    平成18年度新緑会学術講演会, 2006年07月, 平成18年度新緑会学術講演会, 大阪, 国内会議

  • SPIO造影MRIの肝細胞癌診療における役割と留意点
    村上 卓道
    第42回日本肝癌研究会, 2006年07月, 第42回日本肝癌研究会, 東京, 国内会議

  • 大動脈解離後に発症した下腸間膜動脈領域の虚血性腸炎
    任 誠雲, 下野 太郎, 清水 利栄, 葉 輝明, 米矢 吉宏, 坪山 尚寛, 桑原 雅知, 土屋 典生, 岡田 真広, 小塚 健倫, 今岡 いずみ, 足利 竜一朗, 細野 眞, 井上 剛裕, 梅原 泰, 土手 健作, 村上 卓道
    第283回日本医学放射線学会関西地方会, 2006年06月, 第283回日本医学放射線学会関西地方会, 大阪, 症例は73歳男性で、主訴は下痢。大動脈解離(DebakeyI型)術後1週間より発症。CTで解離の及んでいた下腸間膜動脈の閉塞を認め、虚血性腸炎と考えた。解離術後に発生する腸管虚血は稀な合併症で、上腸間膜動脈閉塞が原因となることが多く、下腸間膜動脈が原因となることは極めて稀（本邦１９８５～０３年の間で３例）である。虚血性腸炎発症時期は術後数週からという報告が多い。本症例でも術後1週間から発症しており、虚血性腸炎は解離術後から発症までにはタイムラグがあることを知っておくことは重要である。, 国内会議

  • 腹部MDCT診断
    村上 卓道
    第6回南大阪核医学カンファレンス, 2006年06月, 第6回南大阪核医学カンファレンス, 国内会議

  • 肝のダイナミックMDCTの撮像法とその有用性
    村上 卓道
    114回日本医学放射線学会北日本地方会, 2006年06月, 114回日本医学放射線学会北日本地方会, 秋田, 国内会議

  • 肝腫瘍のMRI診断：3Tを含めて
    村上 卓道
    第17回京都MRI研究会, 2006年06月, 第17回京都MRI研究会, 京都, 国内会議

  • Treatment of uterine myoma with MR guided focused ultrasound: Clinical application in Japan.
    村上 卓道
    11th Congress of the World Federation for Ultrasound in Medicine and Biology 2006,, 2006年06月, 11th Congress of the World Federation for Ultrasound in Medicine and Biology 2006,, Seoul, 国際会議

  • Feasibility of Diffusion-weighted MR Imaging and ADC map to predict necrosis of uterine fibroids during MR Imaging-guided Focused Ultrasound Surgery.
    岡田篤哉, 村上 卓道
    14th International Society for Magnetic Resonance in Medicine., 2006年05月, 14th International Society for Magnetic Resonance in Medicine., Seattle, 国際会議

  • Stepping-Table Gadolinium-Enhanced MR Angiography for the Run-Off Study of Lower Extremity Arteries: Two-Injection Techniques Using Combination of TRICKS for the Calf and Two-Step Scanning Technique with Automated Bolus-Detection Algorithm for the Abdomen
    金 東石, 村上 卓道
    14th International Society for Magnetic Resonance in Medicine., 2006年05月, 14th International Society for Magnetic Resonance in Medicine., Seattle, 国際会議

  • Isotropic Diffusion Weighted MR Imaging with Tetrahedral Gradients in the Upper Abdomen.
    堀 雅敏, 村上 卓道, 桑原 雅知
    14th International Society for Magnetic Resonance in Medicine., 2006年05月, 14th International Society for Magnetic Resonance in Medicine., Seattle

  • 腹部のMDCT診断：撮像法と臨床応用
    村上 卓道
    第222回Open Film Conference, 2006年05月, 第222回Open Film Conference, 群馬大学医学部

  • 腎granular cell carcinomaの一例
    栁生 行伸, 下野 太郎, 岡田 真広, 任 誠雲, 葉 輝明, 米矢 吉宏, 堀川 重樹, 植村 天受, 筑後 孝章, 細野 眞, 村上 卓道
    第20回腹部放射線研究会, 2006年05月, 第20回腹部放射線研究会, 東京, 腹部CTにて左腎腫瘍を指摘されて当院泌尿器科受診。腹部CTでは均一で骨格筋と同程度のCT値であり、内部に小さな石灰化がみられた。脂肪成分は指摘できず。造影CT早期相では均一によく造影されて、後期相では周囲の腎よりも低吸収であったがtime density curve 上は漸増性を示していた。MRI T2強調画像では骨格筋と同程度の低信号であり、chemical shift imageでは微少脂肪成分は指摘できず、in phase, opposed phaseとも腫瘤は腎実質よりも高信号を示していた。Dynamic studyではCT同様均一に造影されている。T2強調画像で腫瘍そのものが低信号を示しており、被膜の同定は不可能であった。脂肪成分が少ない血管筋脂肪腫との鑑別に苦慮したが、clear cell carcinoma以外の悪性腫瘍の可能性も考え、左腎摘出術を施行。Gerota筋膜表面の血管は強く怒張し、易出血性であった。左腎上極の癒着も著しかった。割面は灰白色で均一であった。組織診断はgranurlar cell carcinomaであった。, 国内会議

  • 大腸癌肝転移の診断
    村上 卓道
    日本消化器外科学会教育集会, 2006年02月, 日本消化器外科学会教育集会, 横浜, 国内会議

  • 肝癌のMDCT診断
    村上 卓道
    第34回北摂肝癌研究会, 2006年01月, 第34回北摂肝癌研究会, 大阪, 国内会議

  • 腹部のMDCT：最適撮像法とその臨床応用
    村上 卓道
    日本医学放射線学会・日本放射線専門医会 第19回冬季セミナー, 2006年01月, 日本医学放射線学会・日本放射線専門医会 第19回冬季セミナー, 東京, 国内会議

  • 消化器疾患のMDCT診断
    村上 卓道
    85回日本消化器病学会近畿支部例会, 2006年, 85回日本消化器病学会近畿支部例会, 大阪, 国内会議

  • Feasibility of Diffusion-weighted MR Imaging and ADC Map to Predict Necrosis of Uterine Fibroids during MR Imaging-guided Focused Ultrasound Surgery.
    Okada A, 村上 卓道
    91st Radiological Society of North America, 2005年12月, 91st Radiological Society of North America, Chicago, 国際会議

  • The Precision and Effectiveness of Real-time Virtual Sonography on Radiofrequency Ablation for Hepatocellular Carcinoma.
    村上 卓道, Kitada T
    91st Radiological Society of North America, 2005年12月, 91st Radiological Society of North America, Chicago, 国際会議

  • Detection of Portal Vein Tumor Thrombosis in Patients with Hepatocellular Carcinoma: Comparison of Multi-phasic, Multi-slice CT, and MR Imaging including Gadolinium-enhanced Multi-phasic Imaging.
    Kim T, 村上 卓道
    91st Radiological Society of North America, 2005年12月, 91st Radiological Society of North America, Chicago, 国際会議

  • Optimal Scanning Protocol of 64-channel Multi-detector Row CT for Upper Abdominal Disease.
    村上 卓道, Kim T
    91st Radiological Society of North America, 2005年12月, 91st Radiological Society of North America, Chicago, 国際会議

  • Diagnosis of Liver Tumors: Role of Multi-Detector Row CT and MR Imaging.
    Hori M, 村上 卓道
    91st Radiological Society of North America, 2005年12月, 91st Radiological Society of North America, Chicago, 国際会議

  • Software-based Image fusion for Whole-body PET/CT and PET/MR.
    Hori M, 村上 卓道
    91st Radiological Society of North America, 2005年12月, 91st Radiological Society of North America, Chicago, 国際会議

  • Imaging Findings of Congenital Portosystemic Shunt.
    Abe H, 村上 卓道
    91st Radiological Society of North America, 2005年12月, 91st Radiological Society of North America, Chicago, 国際会議

  • Reduction of Patient’s Dose in Cerebral CT Angiography by Axial Scan of 64 Channel multi-Detector Row CT Scanner: Vessel Phantom Study.
    Kudo M, 村上 卓道
    91st Radiological Society of North America, 2005年12月, 91st Radiological Society of North America, Chicago, 国際会議

  • Percutaneously Implanted Port-Catheter System for Hepatic Arterial infusion Chemotherapy of Hepatocellular Carcinoma.
    Khankan AA, 村上 卓道
    91st Radiological Society of North America, 2005年12月, 91st Radiological Society of North America, Chicago, 国際会議

  • 腹部のMDCTの撮像法とボリュームデータの臨床利用
    村上 卓道
    山形MDCT研究会, 2005年11月, 山形MDCT研究会, 山形, 国内会議

  • 腹部のMDCT：最適撮像法とその臨床応用
    村上 卓道
    第4回北摂MDCTフォーラム, 2005年11月, 第4回北摂MDCTフォーラム, 大阪, 国内会議

  • 腹部領域の造影CT診断：肝臓のMDCT診断：最適撮像法とその有用性
    村上 卓道
    第41回日本医学放射線学会秋季大会, 2005年10月, 第41回日本医学放射線学会秋季大会, 広島, 国内会議

  • MR-guided focused ultrasound surgery.
    村上 卓道, Okada A
    Asia Pacific Cancer Conference, 2005年09月, Asia Pacific Cancer Conference, Seoul, 国際会議

  • 肝臓の画像診断：CT, MRIを中心に
    村上 卓道
    第２回関空肝臓病研究会, 2005年09月, 第２回関空肝臓病研究会, 泉佐野, 国内会議

  • 腹部のMDCT：最適撮像法とVolume dataの利用法
    村上 卓道
    第3回埼玉MDCT研究会, 2005年09月, 第3回埼玉MDCT研究会, 埼玉, 国内会議

  • MRガイド下Focused Ultrasound治療
    村上 卓道
    第19回超音波ドプラ研究会, 2005年09月, 第19回超音波ドプラ研究会, 東京, 国内会議

  • 肝癌のMDCT診断：最適撮像法と有用性
    村上 卓道
    第40回近畿肝癌談話会, 2005年08月, 第40回近畿肝癌談話会, 大阪, 国内会議

  • 肝臓dynamic CTにおける至適造影法：撮像タイミングを中心に MDCT至適造影法を語る会
    村上 卓道
    第1回学術集会：肝臓dynamic CT, 2005年08月, 第1回学術集会：肝臓dynamic CT, 東京, 国内会議

  • 腹部のMDCT診断：最適撮像法とボリュームデータの臨床応用
    村上 卓道
    第１２回関西CT技術シンポジウム, 2005年08月, 第１２回関西CT技術シンポジウム, 大阪, 国内会議

  • 腹部のMDCT：最適撮像法とVolume dataの利用法
    村上 卓道
    MDCTシンポジウム, 2005年07月, MDCTシンポジウム, 盛岡, 国内会議

  • 64列MDCTによる肝臓領域の撮像法について
    村上 卓道
    第11回大阪画像診断学術講演会, 2005年07月, 第11回大阪画像診断学術講演会, 大阪, 国内会議

  • 腹部のMDCT：最適撮像法とVolume dataの利用法
    村上 卓道
    MDCTシンポジウム, 2005年06月, MDCTシンポジウム, 仙台, 国内会議

  • 肝細胞癌の治療適応決定におけるSPIO-MRIの診断法と有用性
    村上 卓道
    第41回日本肝臓学会総会, 2005年06月, 第41回日本肝臓学会総会, 大阪, 国内会議

  • Multidetector-row CT of the abdomen disease: Clinical utility of volumetric data.
    村上 卓道
    Invited lecture in Samsung Medical Center of Sungkyunkwan University School of Medicine, 2005年05月, Invited lecture in Samsung Medical Center of Sungkyunkwan University School of Medicine, Seoul, 国際会議

  • Optimal injection and scanning technique of MDCT of the liver tumor.
    村上 卓道
    Invited lecture in Severance Hospital of Yonsei University College of Medicine, 2005年05月, Invited lecture in Severance Hospital of Yonsei University College of Medicine, Seoul, 国際会議

  • MR-guided focused ultrasound. Symposium of High Intensity Focused Ultrasound Therapy.
    村上 卓道
    In Samsung Medical Center of Sungkyunkwan University School of Medicine, 2005年05月, In Samsung Medical Center of Sungkyunkwan University School of Medicine, Seoul, 国際会議

  • MR-guided focused ultrasound
    村上 卓道
    Invited lecture in Seoul National University College of Medicine, 2005年05月, Invited lecture in Seoul National University College of Medicine, Seoul, 国際会議

  • Multidetector-row CT of the abdomen disease: Optimal scanning technique and Clinical utility of volumetric data.
    村上 卓道
    Invited lecture in Asan Medical Center of University of Ulsan College of Medicine, 2005年05月, Invited lecture in Asan Medical Center of University of Ulsan College of Medicine, Seoul, 国際会議

  • The role of SPIO enhanced MR imaging of the liver.
    村上 卓道
    Invited lecture in Asan Medical Center of University of Ulsan College of Medicine, 2005年05月, Invited lecture in Asan Medical Center of University of Ulsan College of Medicine, Seoul, 国際会議

  • MR-guided focused ultrasound surgery for uterine fibroid.
    村上 卓道, Okada A
    The 9th International Symposium on Interventional Radiology & New Vascular Imaging, 2005年05月, The 9th International Symposium on Interventional Radiology & New Vascular Imaging, Awaji, 国内会議

  • 腹部のMSCT診断
    村上 卓道
    MSCT Forum in Kanazawa, 2005年05月, MSCT Forum in Kanazawa, 金沢, 国内会議

  • 肝細胞癌の診断におけるSPIO-MRIの有用性と役割
    村上 卓道
    第91回日本消化器病学会総会, 2005年04月, 第91回日本消化器病学会総会, 東京, 国内会議

  • Optimal injection and scanning technique of arterial imaging of liver tumor.
    村上 卓道
    Abdominal Radiology Course 2005, 2005年03月, Abdominal Radiology Course 2005, San Antonio, 国際会議

  • Development and diagnostic usefulness of PET-MR fusion imaging software for the abdomen.
    Hori M, 村上 卓道
    The 34th Annual Postgraduate Course and the SGR and the 30th Scientific Assembly of the SUR, 2005年03月, The 34th Annual Postgraduate Course and the SGR and the 30th Scientific Assembly of the SUR, San Antonio, Texas, 国際会議

  • Diagnosis of Portal Vein Tumor Thrombosis in Patients with Hepatocellular Carcinoma by Means of Multi-phasic Contrast Enhanced Multi-slice CT.
    Kim T, 村上 卓道
    The 34th Annual Postgraduate Course and the SGR and the 30th Scientific Assembly of the SUR, 2005年03月, The 34th Annual Postgraduate Course and the SGR and the 30th Scientific Assembly of the SUR, San Antonio, Texas, 国際会議

  • MRガイド下Focused Ultrasound治療
    村上 卓道
    第20回高度先進医療研究会, 2005年02月, 第20回高度先進医療研究会, 東京, 国内会議

  • Comparison of the Hepatic Perfusion Parameters in Patients with Normal and Chronic Liver Disease
    Kudo M, 村上 卓道
    90th Radiological Society of North America, 2004年12月, 90th Radiological Society of North America, Chicago, 国際会議

  • Normal Liver Perfusion Value Measurements by Means of Deconvolution Analysis of Serial CT Images for Potential Living Liver Donors: Animal Experimental Study and Human Study
    Kudo M, 村上 卓道
    90th Radiological Society of North America, 2004年12月, 90th Radiological Society of North America, Chicago, 国際会議

  • Evaluation of Arterial Blood Flow Speed by Means of Double Mini-bolus Test Injection Technique at CT
    Kim T, 村上 卓道
    90th Radiological Society of North America, 2004年12月, 90th Radiological Society of North America, Chicago, 国際会議

  • Development and diagnostic usefulness of fusion imaging software for PET/CT without unified scanner
    Hori M, 村上 卓道
    90th Radiological Society of North America, 2004年12月, 90th Radiological Society of North America, Chicago, 国際会議

  • Quantitative assessment of hepatic damage and fibrosis grade by means of CT perfusion imaging
    Hashimoto K, 村上 卓道
    90th Radiological Society of North America, 2004年12月, 90th Radiological Society of North America, Chicago, 国際会議

  • Optimal Scan Timing of Double Arterial Phase Imaging after Arrival of Contrast Medium to the Abdominal Aorta on Dynamic Multi-Detector CT of the Liver.
    村上 卓道, Onishi H
    90th Radiological Society of North America, 2004年12月, 90th Radiological Society of North America, Chicago, 国際会議

  • Simultaneous Measurement of Regional Hepatic Tissue Blood Flow by Xenon CT and Perfusion CT: A Validation Study.
    Hashimoto K, 村上 卓道
    90th Radiological Society of North America, 2004年12月, 90th Radiological Society of North America, Chicago, 国際会議

  • Comparison MR Imaging-guided Focused Ultrasound Surgery with Uterine Artery Embolization in the Management of Fibroid-related Menorrhagia.
    Mikami K, 村上 卓道
    90th Radiological Society of North America, 2004年12月, 90th Radiological Society of North America, Chicago, 国際会議

  • Evaluation of Optimal Timing of Arterial Phase Imaging for the Detection of Hypervascular Hepatocellular Carcinoma with Multi-Detector Row Helical CT.
    Takamura M, 村上 卓道
    90th Radiological Society of North America, 2004年12月, 90th Radiological Society of North America, Chicago, 国際会議

  • The role of SPIO enhanced MR imaging of the liver: The strategy and experience of imaging diagnosis of HCC in Osaka University/Japan
    村上 卓道
    2004 International Symposium of HCC, 2004年11月, 2004 International Symposium of HCC, Taipei, 国際会議

  • 腹部領域におけるMDCT診断
    村上 卓道
    香川消化器病研究会, 2004年11月, 香川消化器病研究会, 香川, 国内会議

  • 放射線医学的治療：IVRと放射線治療
    村上 卓道
    第28回大阪府医師会医学会総会 第36回医療近代化シンポジウム, 2004年11月, 第28回大阪府医師会医学会総会 第36回医療近代化シンポジウム, 大阪, 国内会議

  • 大腸癌診療における画像診断の進歩：MDCT, MRI, PET
    村上 卓道
    第59回日本大腸肛門病学会総会, 2004年11月, 第59回日本大腸肛門病学会総会, 久留米, 国内会議

  • ワークショップ：肝細胞癌診断における各種診断法の評価：肝細胞癌の描出：Dynamic MDCT, Dynamic MRI, SPIO造影MRI, CTHA, CTAPの比較検討
    村上 卓道
    第8回日本肝臓学会大会 第46回日本消化器病学会大会 DDW-JAPAN, 2004年10月, 第8回日本肝臓学会大会 第46回日本消化器病学会大会 DDW-JAPAN, 福岡, 国内会議

  • 肝胆膵の造影MDCT:最適造影剤注入法と撮像タイミングを中心に
    村上 卓道
    第32回日本放射線技術学会 秋季大会, 2004年10月, 第32回日本放射線技術学会 秋季大会, 大阪, 国内会議

  • Percutaneous microwave coagulation therapy and radiofrequency ablation for hepatocellular carcinoma with arterial and /or venous blockage of blood flow.
    Fahrni M, 村上 卓道
    Cirse, 2004年09月, Cirse, Barcelona, 国際会議

  • Multidetector-CT of the liver disease
    村上 卓道
    MDCT symposium in Korea, 2004年09月, MDCT symposium in Korea, Kwangju, 国際会議

  • 腹部MDCT：最適撮像法と機能診断法
    村上 卓道
    第14回誰にでもわかる画像診断の会, 2004年09月, 第14回誰にでもわかる画像診断の会, 大阪, 国内会議

  • 消化器系疾患のMDCT診断：2Dから4Dまで
    村上 卓道
    第10回北海道造影画像セミナー, 2004年09月, 第10回北海道造影画像セミナー, 札幌, 国内会議

  • 子宮筋腫の治療：子宮筋腫に対する集束超音波療法（Focused Ultrasound Surgery）
    村上 卓道
    The 5th annual symposium Japanese society for the advancement of women’s imaging (JSAWI), 2004年09月, The 5th annual symposium Japanese society for the advancement of women’s imaging (JSAWI), 淡路, 国内会議

  • 肝癌の画像診断
    村上 卓道
    臨床研究・教育支援センター 社会人医学教育セミナー, 2004年08月, 臨床研究・教育支援センター 社会人医学教育セミナー, 大阪, 国内会議

  • CT・MRI時代の超音波：肝腫瘍のCT・MRI
    村上 卓道
    日本超音波学会第28回関西地方会, 2004年08月, 日本超音波学会第28回関西地方会, 大阪, 国内会議

  • 肝のDynamic MR and MDCT
    村上 卓道
    第7回北海道動態診断セミナー, 2004年06月, 第7回北海道動態診断セミナー, 札幌, 国内会議

  • 肝癌の診断と治療: MDCTとSPIO造影MRIを用いた肝細胞癌の検出－CTHA, CTAPとの比較検討－
    今井 康陽, 村上 卓道
    第40回肝臓学会総会, 2004年06月, 第40回肝臓学会総会, 浦安, 国内会議

  • CT and angio CT of HCC
    村上 卓道
    10 th Asia Oceanian Congress of Radiology, 2004年05月, 10 th Asia Oceanian Congress of Radiology, Singapore, 国際会議

  • 肝腫瘍診断における造影MDCT
    村上 卓道
    第63回日本医学放射線学会, 2004年04月, 第63回日本医学放射線学会, 横浜, 国内会議

  • Targeted transarterial chemoembolization of hepatic tumors using the unified computed tomography-angiography system
    Khankan AA, 村上 卓道
    Society of Interventional Radiology, 2004年03月, Society of Interventional Radiology, Phoenix, 国際会議

  • Hepatocellular carcinoma treated with radiofrequency ablation: an early evaluation with magnetic resonance imaging
    Khankan AA, 村上 卓道
    Society of Interventional Radiology, 2004年03月, Society of Interventional Radiology, Phoenix, 国際会議

  • Invasive pancreatic cancer developed during the follow-up observation of intraductal papillary mucinous tumor
    Kim T, 村上 卓道
    Abdominal Radiology Course 2004, 2004年03月, Abdominal Radiology Course 2004, Scottsdale, 国際会議

  • MR imaging- guided focused ultrasound surgery in the management of symptomatic uterine fibroids: Initial experience and clinical evaluation
    Mikami K, 村上 卓道
    European Congress of Radiology, 2004年03月, European Congress of Radiology, Vienna, 国際会議

  • Real Time Navigation Surgery Using 3D CT in Laparoscopic Gastric Surgery
    Takiguchi S, 村上 卓道
    Ninth World Congress of Endoscopic, 2004年02月, Ninth World Congress of Endoscopic, Cancun, Mexico, 国際会議

  • 最適化されたdynamic MDCTとSPIO-MRIによる肝癌の診断
    村上 卓道
    第4回Tokyo contrast enhanced liver MR meeting (TCEL MR meeing), 2004年02月, 第4回Tokyo contrast enhanced liver MR meeting (TCEL MR meeing), 東京, 国内会議

  • 胆膵のMDCT・MRCP
    村上 卓道
    第9回阪神腹部画像診断治療研究会, 2004年02月, 第9回阪神腹部画像診断治療研究会, 西宮, 国内会議

  • 肝胆膵領域におけるマルチスライスCTの臨床応用
    村上 卓道
    第23回日本画像医学会, 2004年02月, 第23回日本画像医学会, 東京, 国内会議

  • 大腸癌画像診断の最近の進歩
    村上 卓道
    第60回大腸癌研究会, 2004年01月, 第60回大腸癌研究会, 大阪, 国内会議

  • AFROC analysis for diagnosis of elevated lesion of colon at multidetector-row CT colonography: Can two-way observation improve the diagnosis of lesion?
    Yasumoto T, 村上 卓道
    89th Radiological Society of North America, 2003年12月, 89th Radiological Society of North America, Chicago, 国際会議

  • Non-rigid volume registration for dynamic CT data of the liver
    Masumoto J, 村上 卓道
    89th Radiological Society of North America, 2003年12月, 89th Radiological Society of North America, Chicago, 国際会議

  • Noninvasive method for calculating relative ratio of corresponding blood supplying area in renal donor with duplicated renal arteries using multidetector CT.
    Kuwabara M, 村上 卓道
    89th Radiological Society of North America, 2003年12月, 89th Radiological Society of North America, Chicago, 国際会議

  • Percutaneous microwave coagulation therapy (PMCT) and radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) with interruption of arterial and/or portal venous blood flow: Is portal blood flow interruption effective for PMCT
    Fahrni M, 村上 卓道
    89th Radiological Society of North America, 2003年12月, 89th Radiological Society of North America, Chicago, 国際会議

  • Quantitative tissue blood flow evaluation of pancreatic tumor: Comparison between xenon CT and perfusion CT-based on deconvolution analysis
    Abe H, 村上 卓道
    89th Radiological Society of North America, 2003年12月, 89th Radiological Society of North America, Chicago, 国際会議

  • Multi-detector row helical CT imaging of hepatocellular carcinoma
    村上 卓道, Kim T
    89th Radiological Society of North America, 2003年12月, 89th Radiological Society of North America, Chicago, 国際会議

  • Iron and iodized oil emulsion (I-I Emulsion) has a possibility of enhancing an effect of radiofrequency ablation therapy (RFA) of hepatic tumor
    Uyama H, 村上 卓道
    11th United European Gastroenterology week, 2003年11月, 11th United European Gastroenterology week, Madrid, 国際会議

  • Test injection technique of abdominal MDCT
    村上 卓道
    Invited lecture. Radiology. Rome University Medical School, 2003年11月, Invited lecture. Radiology. Rome University Medical School, Rome, 国際会議

  • MR Imaging of liver tumor: Superparamagnetic iron oxide
    村上 卓道
    Invited lecture. Radiology. Rome University Medical School, 2003年11月, Invited lecture. Radiology. Rome University Medical School, Rome, 国際会議

  • MDCT imaging of the abdomen with respiratory gating system: Prospective trigerring and retrospective gating.
    村上 卓道
    4rd International Workshop on Multislice CT, 3D Imaging, Virtual Endoscopy., 2003年11月, 4rd International Workshop on Multislice CT, 3D Imaging, Virtual Endoscopy., Rome, 国際会議

  • 腹部腫瘍に対する凍結治療の有用性：他のintervention治療との比較：子宮筋腫に対する集束超音波療法(FUS)
    村上 卓道
    第30回日本低温医学会総会, 2003年11月, 第30回日本低温医学会総会, 札幌, 国内会議

  • 集束超音波治療
    村上 卓道
    第４回つきじ放射線研究会, 2003年10月, 第４回つきじ放射線研究会, 東京, 国内会議

  • 胆膵疾患のMDCT診断
    村上 卓道
    第3回阪神胆膵疾患研究会, 2003年10月, 第3回阪神胆膵疾患研究会, 甲子園, 国内会議

  • 肝転移に対する新しいアプローチ：低侵襲・Cost effectiveな肝転移診断
    村上 卓道
    第45回日本消化器病学会大会, 2003年10月, 第45回日本消化器病学会大会, 大阪, 国内会議

  • コンセンサスミーティング・治療 肝細胞癌：局所療法-Radiological Intervention
    村上 卓道
    第7回日本肝臓学会大会 第45回日本消化器病学会大会 DDW-JAPAN, 2003年10月, 第7回日本肝臓学会大会 第45回日本消化器病学会大会 DDW-JAPAN, 大阪, 国内会議

  • 造影剤を用いた肝血流画像・機能画像の進歩, 肝疾患の病態にどこまで肉薄できるか：ＣＴ
    村上 卓道
    第39回日本医学放射線学会秋期臨床大会, 2003年10月, 第39回日本医学放射線学会秋期臨床大会, 神戸, 国内会議

  • 子宮筋腫に対する集束超音波療法
    村上 卓道
    第3回子宮動脈塞栓療法研究会, 2003年09月, 第3回子宮動脈塞栓療法研究会, 東京, 国内会議

  • 肝癌の集束超音波法の現状と今後の展望：肝癌治療への可能性
    村上 卓道
    腹腔鏡談話会, 2003年09月, 腹腔鏡談話会, 東京, 国内会議

  • 転移性肝癌におけるMDCT、SPIO-MRIの役割
    村上 卓道
    大腸癌治療サマーセミナー, 2003年08月, 大腸癌治療サマーセミナー, 大阪, 国内会議

  • MRCP with a Combination of Respiratory-triggered 3D Fast Recovery Fast Spin-echo (FRFSE) Sequence and a Parallel Imaging Technique: A comparison with 2D Single-shot Fast Spin-echo (SSFSE) Sequence
    Hori M, 村上 卓道
    Eleventh International Society for Magnetic Resonance in Medicine, 2003年07月, Eleventh International Society for Magnetic Resonance in Medicine, Toronto, 国際会議

  • よくある疾患：腹部編
    村上 卓道
    第22回東京MRI研究会, 2003年07月, 第22回東京MRI研究会, 東京, 国内会議

  • MDCTおよびSPIO-MRIによる腹部の画像診断
    村上 卓道
    第7回平成外科カンファレンス, 2003年06月, 第7回平成外科カンファレンス, 大阪, 国内会議

  • 腹部のＭＤＣＴ診断
    村上 卓道
    第17回Hepato－Gastroenterology Today for the post graduate（H-GPT）, 2003年06月, 第17回Hepato－Gastroenterology Today for the post graduate（H-GPT）, 島根, 国内会議

  • A newly developed iron and iodized oil emulsion (I-I emulsion) for enhancing an effect of radiofrequency ablation therapy (RFA) of hepatic tumor
    Uyama H, 村上 卓道
    Digestive Disease Week 2003, 2003年05月, Digestive Disease Week 2003, Orlando, 国際会議

  • 子宮筋腫・乳腺腫瘍に対するFUS：開発状況の紹介
    三上恒治, 村上 卓道
    第19回日本医工学治療学会, 2003年05月, 第19回日本医工学治療学会, 札幌, 国内会議

  • 肝細胞癌に対する血流遮断下熱凝固療法と肝切除の比較
    石田 毅, 村上 卓道
    第３２回日本血管造影・Interventional Radiology総会, 2003年05月, 第３２回日本血管造影・Interventional Radiology総会, 神戸, 国内会議

  • 治療における腹部MDCTの応用
    村上 卓道
    第4回岡山マルチスライスCTセミナー, 2003年03月, 第4回岡山マルチスライスCTセミナー, 岡山, 国内会議

  • IVR技術による組織デリバリィ
    村上 卓道
    第２回日本再生医療学会大会, 2003年03月, 第２回日本再生医療学会大会, 神戸, 国内会議

  • Quantitative evaluation of hepatic tissue perfusion by using deconvolution analysis
    村上 卓道, Hori M
    Abdominal Radiology Course 2003, 2003年02月, Abdominal Radiology Course 2003, Cancun, Mexico, 国際会議

  • 肝癌治療における腹部MDCTの術前・術後評価
    村上 卓道
    第40回京都肝疾患懇話会, 2003年02月, 第40回京都肝疾患懇話会, 京都, 国内会議

  • 肝癌のＭＤＣＴ・ＭＲ診断
    村上 卓道
    第8回筑後肝癌研究会, 2003年02月, 第8回筑後肝癌研究会, 久留米, 国内会議

  • 子宮筋腫・乳腺腫瘍に対するFUS；開発状況の紹介
    村上 卓道
    第22回日本画像医学会, 2003年02月, 第22回日本画像医学会, 東京, 国内会議

  • Quantitative assessent of each histological grade of hepatocellular carcinoma tissue blood flow with xenon-enhanced CT
    Sugihara E, 村上 卓道
    88th Radiological Society of North America, 2002年12月, 88th Radiological Society of North America, Chicago, 国際会議

  • Evaluation of arterial stenosis of lower extremities with multidetector-row CT angiography (MDCTA): Comparison to conventional digital subtraction angiography
    Sugihara E, 村上 卓道
    88th Radiological Society of North America, 2002年12月, 88th Radiological Society of North America, Chicago, 国際会議

  • Evaluation of renal arteries in living renal donors: Comparison of the accuracy of contrast-enhanced CT angiography using multidetector-row helical CT and gadolinium-enhanced MR angiographyusing 3D Fourier transformation gradient echo
    Kim T, 村上 卓道
    88th Radiological Society of North America, 2002年12月, 88th Radiological Society of North America, Chicago, 国際会議

  • Multidetector CT angiography of upper abdominal arteries using an eight-detector row CT scanner
    Kawata S, 村上 卓道
    88th Radiological Society of North America, 2002年12月, 88th Radiological Society of North America, Chicago, 国際会議

  • Usefulness of newly developed interactive multiplanar reconstruction viewer for large amount of image sets by multidetector-row CT: Evaluation of invasion to surrounding organs b esophageal carcinoma
    Johkoh T, 村上 卓道
    88th Radiological Society of North America, 2002年12月, 88th Radiological Society of North America, Chicago, 国際会議

  • High spatial resolution hepatic CT microangiography with synchrotron radiation system: Experimental study with rats
    Hori M, 村上 卓道
    88th Radiological Society of North America, 2002年12月, 88th Radiological Society of North America, Chicago, 国際会議

  • 肝腫瘍の治療とMDCT
    村上 卓道
    第一回肝疾患・診療の最前線, 2002年11月, 第一回肝疾患・診療の最前線, 大阪, 国内会議

  • 腹部のMDCT診断
    村上 卓道
    近畿医療技術専門学校放射線科学友会講演会, 2002年11月, 近畿医療技術専門学校放射線科学友会講演会, 大阪, 国内会議

  • 腹部のMDCT
    村上 卓道
    西宮MDCT講演会, 2002年11月, 西宮MDCT講演会, 西宮, 国内会議

  • 肝癌IVR治療効果判定；CT（腫瘍のCTによる治療効果予測, 効果判定）
    村上 卓道
    第31回断層映像研究会, 2002年11月, 第31回断層映像研究会, 高知, 国内会議

  • 肝組織特異性造影剤の撮像法
    村上 卓道
    第30回日本放射線技術学会秋季学術大会, 2002年10月, 第30回日本放射線技術学会秋季学術大会, 島根, 国内会議

  • 新しいMRI用造影剤SPIOの臨床応用：SPIO製剤の基本的撮像方法とその特徴
    村上 卓道
    第38回日本医学放射線学会秋期臨床大会, 2002年10月, 第38回日本医学放射線学会秋期臨床大会, 秋田, 国内会議

  • 肝腫瘍の造影MDCT
    村上 卓道
    第38回日本医学放射線学会秋期臨床大会, 2002年10月, 第38回日本医学放射線学会秋期臨床大会, 秋田, 国内会議

  • Multidetector-row CT in liver imaging
    村上 卓道
    Asian Pacific Association for the Society of the Liver Meeting, 2002年09月, Asian Pacific Association for the Society of the Liver Meeting, Taipei, 国際会議

  • 肝細胞癌に対する血流遮断下経皮的ラジオ波凝固法
    石田 毅, 村上 卓道
    日本血管造影・Interventional Radiology学会 第12回関西地方会, 2002年09月, 日本血管造影・Interventional Radiology学会 第12回関西地方会, 京都, 国内会議

  • 肝のＭＤＣＴ・ＭＲ診断
    村上 卓道
    第４４回腹部画像診断カンファレンス, 2002年08月, 第４４回腹部画像診断カンファレンス, 大阪, 国内会議

  • MSCT Imaging of the Liver Tumor. 3rd International Workshop on Multislice CT, 3D Imaging
    村上 卓道
    Virtual Endoscopy, 2002年06月, Virtual Endoscopy, Rome, 国際会議

  • MSCT Imaging of Stomach Cancer. 3rd International Workshop on Multislice CT, 3D Imaging
    村上 卓道
    Virtual Endoscopy, 2002年06月, Virtual Endoscopy, Rome, 国際会議

  • 肝の造影MRI －SPIOを中心として
    村上 卓道
    第10回三重総合画像診断研究会, 2002年06月, 第10回三重総合画像診断研究会, 津, 国内会議

  • Three-dimensional visualization of catheter using stereoscopic MR images
    Kumamoto E, 村上 卓道
    10th International Society for Magnetic Resonance in Medicine, 2002年05月, 10th International Society for Magnetic Resonance in Medicine, Honolulu, 国際会議

  • Fusion of SPIO-enhanced MR images and volume data sets obtained with multi-detector row helical CT scanner: Improved ability for hepatic tumor diagnosis
    Hori M, 村上 卓道
    10th International Society for Magnetic Resonance in Medicine, 2002年05月, 10th International Society for Magnetic Resonance in Medicine, Honolulu, 国際会議

  • Hepatic tissue specific contrast MR media
    村上 卓道
    The 8th International Symposium on Interventional Radiology & New Vascular Imaging, 2002年05月, The 8th International Symposium on Interventional Radiology & New Vascular Imaging, 東京, 国際会議

  • 大腸癌のCT・MRI診断：局所および肝転移
    村上 卓道
    第1回大腸癌治療フォーラム, 2002年05月, 第1回大腸癌治療フォーラム, 大阪, 国内会議

  • 肝の造影MRI：超常磁性酸化鉄粒子（SPIO）を中心に
    村上 卓道
    阪神画像診断研究会, 2002年05月, 阪神画像診断研究会, 甲子園, 国内会議

  • 肝疾患のＭＲＩ診断
    村上 卓道
    造影ＭＲシンポジウム, 2002年03月, 造影ＭＲシンポジウム, 大阪, 国内会議

  • 肝の造影CT・MRI
    村上 卓道
    第40回京滋奈良消化器画像医学研究会, 2002年02月, 第40回京滋奈良消化器画像医学研究会, 京都, 国内会議

  • 肝細胞癌の画像診断：新しい造影剤と診断機器の進歩：マルチスライス(MDCT)を用いた肝細胞癌の診断：至適撮像法と診断能, 再構成3D画像の臨床応用
    村上 卓道
    第21回日本画像医学会, 2002年02月, 第21回日本画像医学会, 東京, 国内会議

  • MRIの肝組織特異性造影剤
    村上 卓道
    第12回近畿MRI講演会, 2002年01月, 第12回近畿MRI講演会, 大阪, 国内会議

  • 消化器病変のＭＤＣＴ診断
    村上 卓道
    第5回阪神腹部画像治療研究会, 2002年01月, 第5回阪神腹部画像治療研究会, 甲子園, 国内会議

  • Detection of hypervascular hepatocellular carcinoma with dynamic MR imaging: Which Is best opposed-phase, in-phase, or double-phase gradient-echo MR imaging?
    Sugihara E, 村上 卓道
    87th Radiological Society of North America., 2001年12月, 87th Radiological Society of North America., Chicago, 国際会議

  • New technique of embolic coil placement for exclision of the splenic artery aneurysms.
    Maeda M, 村上 卓道
    87th Radiological Society of North America, 2001年12月, 87th Radiological Society of North America, Chicago, 国際会議

  • Newly developed software for interactive multiplanar reconstruction view: Demonstration on note PC
    Yamamoto S, 村上 卓道
    87th Radiological Society of North America, 2001年11月, 87th Radiological Society of North America, Chicago, 国際会議

  • Preoperative evaluation of living renal donors: Comparison of muotidetector-row helical CT angiography and 3D MR angiography
    Kim T, 村上 卓道
    87th Radiological Society of North America, 2001年11月, 87th Radiological Society of North America, Chicago

  • Effect of iodine concentration of contrast material on vascular carcinoma in patients with chronic liver disease
    Kim T, 村上 卓道
    87th Radiological Society of North America, 2001年11月, 87th Radiological Society of North America, Chicago, 国際会議

  • Quantitative assessment of hepatic tumor tissue blood flow with xenon-enhanced CT
    村上 卓道, Shimizu J
    87th Radiological Society of North America, 2001年11月, 87th Radiological Society of North America, Chicago, 国際会議

  • Quantitative assessment of hepatic damage by measuring the hepatic tissue blood flow with xenon-enhanced CT
    村上 卓道, Hayashi S
    87th Radiological Society of North America, 2001年11月, 87th Radiological Society of North America, Chicago, 国際会議

  • Double arterial phase imaging of the liver with use of multidetector-row helical CT and automatic bolus tracking technique
    Kim T, 村上 卓道
    87th Radiological Society of North America, 2001年11月, 87th Radiological Society of North America, Chicago, 国際会議

  • Magnetic compression anastomosis of the vascular system in experimental dog models: Feasibility study.
    Sugiura T, 村上 卓道
    87th Radiological Society of North America., 2001年11月, 87th Radiological Society of North America., Chicago, 国際会議

  • Supplementary value of multi-shot and single?shot fast SE imaging in ferumoxide-enhanced MR imaging for detection of malignant hepatic tumors: Observe performance study using McNemar’s test and ROC analysis for clustered data
    Matsuo M, 村上 卓道
    87th Radiological Society of North America, 2001年11月, 87th Radiological Society of North America, Chicago, 国際会議

  • Breath-hold T2-weighted imaging of hepatic lesions by using fast recovery, fast spin ?echo sequence.
    Kim T, 村上 卓道
    87th Radiological Society of North America, 2001年11月, 87th Radiological Society of North America, Chicago., 国際会議

  • A newly developed xenon CT imaging for separately measurement of the hepatic arterial and portal venous tissue blood flow: An animal study.
    Hayashi S, 村上 卓道
    87th Radiological Society of North America., 2001年11月, 87th Radiological Society of North America., Chicago, 国際会議

  • 腹部ＭＤＣＴプロトコール；よりよいダイナミックスタディー・ＣＴアンギオのために
    村上 卓道
    第8回大阪画像診断学術講演会（ODIS）, 2001年10月, 第8回大阪画像診断学術講演会（ODIS）, 大阪, 国内会議

  • 最近の肝ＭＲＩ
    村上 卓道
    第２５回四国MRI研究会, 2001年10月, 第２５回四国MRI研究会, 高松, 国内会議

  • 食道及び胃癌のらせんＣＴ及びＭＲＩ
    村上 卓道
    43回日本消化器病学会大会, 2001年10月, 43回日本消化器病学会大会, 京都, 国内会議

  • 胆道疾患の診断－現況と将来：ＣＴ・ＭＲＩ
    村上 卓道
    第９０回大阪胆道疾患研究会, 2001年09月, 第９０回大阪胆道疾患研究会, 大阪, 国内会議

  • 腹部領域におけるＭＤＣＴの適応：Liver
    村上 卓道
    第一回国際ＭＤＣＴシンポジウム, 2001年09月, 第一回国際ＭＤＣＴシンポジウム, 東京, 国内会議

  • 肝・胆・膵の画像診断
    村上 卓道
    播淡画像診断研究会, 2001年06月, 播淡画像診断研究会, 西明石, 国内会議

  • 肝血流遮断下経皮的マイクロ波腫瘍凝固療法
    村上 卓道, 柴田 高
    第23回日本癌局所療法研究会, 2001年06月, 第23回日本癌局所療法研究会, 大阪, 国内会議

  • 肝の造影マルチスライスＣＴ
    村上 卓道
    第10回放射線と造影剤シンポジウム（CMRS）, 2001年05月, 第10回放射線と造影剤シンポジウム（CMRS）, 東京, 国内会議

  • 最新の肝のＣＴ、ＭＲ診断
    村上 卓道
    第４回兵庫肝臓フォーラム, 2001年04月, 第４回兵庫肝臓フォーラム, 神戸, 国内会議

  • 肝癌のＭＤＣＴ・ＭＲ診断
    村上 卓道
    第４回東京肝腫瘍診断研究会, 2001年03月, 第４回東京肝腫瘍診断研究会, 東京, 国内会議

  • 肝細胞癌の血行動態はどこまでわかったか：キセノンＣＴによる肝細胞癌血流の定量的評価の試み
    村上 卓道
    第７回肝血流動態イメージ研究会, 2001年02月, 第７回肝血流動態イメージ研究会, 東京, 国内会議

  • 肝の造影ＭＲＩ
    村上 卓道
    第20回日本画像医学会, 2001年01月, 第20回日本画像医学会, 四日市, 国内会議

  • New CT techniques in abdominal radiology. Application of novel imaging techniques in abdominal imaging.
    Murakami T
    AOCR2022 ＆ KCR2022.

■ 所属学協会
  • Radiological Society of North America

  • Society of Gastrointestinal Radiologists

  • インターベンショナルラジオロジー学会

  • 日本血管造影

  • 日本肝臓学会

  • 日本消化器病学会

  • 日本核磁気共鳴医学会

  • 北米放射線学会

  • 日本医学学放射線学会

■ Works_作品等
  • CT/MR装置による腹部領域の機能画像診療ソフトウェアの臨床的有用性の研究及び開発
    2005年

  • CT/MR装置による機能画像診断システムの構築とその臨床的有用性の検証
    2003年

  • 造影剤MRIによる、Radio Frequency(RF)治療の肝腫瘍モデルに対する治療効果判定の可能性の検討
    2003年

■ 共同研究・競争的資金等の研究課題
  • 肝細胞癌に対する免疫療法の治療効果を予測する非侵襲的バイオマーカー開発
    村上 卓道, 鶴崎 正勝, 上嶋 英介, 小松 正人, 祖父江 慶太郎
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2023年04月01日 - 2026年03月31日

  • 人工知能を用いた膵癌CT自動診断システム開発とスクリーニング・早期診断への応用
    祖父江 慶太郎, 村上 卓道, 上嶋 英介, 上野 嘉子, 増田 充弘
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2022年04月 - 2025年03月
    腹部造影CT画像に対して画像AI技術を用い、膵腫瘤および膵癌に付随する頻度の高い二次所見（主膵管拡張、主膵管狭窄、膵萎縮）の自動検出による膵癌自動診断システムの構築を試みた。深層学習を用いて、膵実質、膵管、腫瘤の各領域を自動抽出し、抽出結果に基づき膵腫瘤性病変ならびに二次所見の有無を判定可能なAIエンジンを構築した。トレーニングセット・バリデーションセットとして膵癌群587例、対照群432例を用い、テストデータとして関連施設より収集した膵癌群62例、対照群90症例を対象に、膵腫瘤検出AI単独による膵癌検出精度ならびに膵腫瘤検出AIと二次所見検出AIの組合せによる膵癌検出精度を評価・算出した。 テストデータにおける腫瘤検出AIのみによる膵癌検出能は、感度73.3%、特異度96.7%であった。腫瘤検出AIと二次所見検出AIの組合せによる膵癌検出能は、感度93.5%、特異度84.4%であった。二次所見検出AIを組み合わせることにより検出感度が向上するとともに、腫瘤検出AI単独では検出できなかったTisやT1等の小膵癌に対しても検出成功例が増加した。

  • 門脈血流・肝機能定量MRIによる分離門脈血流・肝機能評価の検討
    小松 昇平, 村上 卓道, 福本 巧, 祖父江 慶太郎
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2021年04月 - 2024年03月
    実験用ファントムを用いたMRI基礎研究によって門脈分枝血流および分肝機能評価（Gd-EOB-DTPA造影剤の定量測定）に最適なパラメータを設定する。次に肝癌術前症例に対して門脈血流・肝機能定量MRIを実施し、各区域の門脈血流量および肝機能を定量測定することで普遍的な分離門脈血流・肝機能評価を行う。つまりMRIで定量的門脈血流ならびに肝機能測定を行い、術前・術後の肝区域毎の分肝機能を定量し、区域レベルでの詳細な機能評価・機能推移を実現する。将来的に肝切除対象例における残存予定区域のみで算出されたより精度の高い肝予備能評価法を確立することを目標としている。現在動態ファントムを用いた血流評価の準備を進めている。また現在使用されている造影MRIの肝血流と肝機能の関連を検討し、学会発表予定である。

  • 上嶋英介, 平田 豊, 児玉大志, 祖父江慶太郎, 村上卓道
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2020年04月 - 2023年03月
    luciferase遺伝子導入N1S1ラット肝癌細胞を用いて同種移植肝癌モデルを作成した。腫瘍移植後7日目に頸動脈より細経のマイクロカテーテルを挿入し、肝動脈 を選択し、破砕したゼラチン物質にて腫瘍動脈の塞栓術を行った。さらに1週間後にIVISにて腫瘍壊死および残存組織の発光をIVISにて確認した。その後、 Sacrificeを行い、肝癌移植・辺縁部をまとめて摘出し、mRNA抽出を行い、microarrayによる網羅的遺伝子解析を行った。TAE群ではTAMに関与する遺伝子群の発現が増加傾向にあり、これらはLenvatinib併用群では減少する傾向にあった。TAEにより生じた腫瘍免疫微小環境のTAM増加に向かう変化がLenvatinibにより修正されうる可能性が示唆された。さらにラット脛骨より骨髄細胞を採取し、M-CSF投与によりマクロファージへと分化させ た。同骨髄由来マクロファージとN1S1細胞を用いてマクロファージ極性変化を評価した。Lenvatinibとマクロファージのみに投与しても極性変化は見られなかっ たが、N1S1のConditioned mediumを加えるとマクロファージ極性変化が生じ、Lenvatinib投与により改善が見られた。よって、Lenvatinibはマクロファージに作 用するのではなく、腫瘍細胞に作用し、その結果、腫瘍より放出されるサイトカインによりマクロファージ極性変化が生じることが予想された。 以上の結果をまとめて、関連学会にて報告、英文校正を経て関連学会雑誌に投稿中である。

  • 説明できるAIの基盤技術開発／モジュール型モデルによる深層学習のホワイトボックス化
    鈴木賢治, 村上卓道, 堀 雅敏, 河野 淳
    国立研究開発法人新エネルギー・産業技術総合開発機構 人と共に進化する次世代人工知能に関する技術開発事業, NEDO, 東京工業大学, 2020年04月 - 2022年03月, 研究分担者
    本研究の目的は、Dual-Energy CTで撮像したダイナミック造影CTから得られるヨードマップを用いて膵癌内部の線維性間質の多寡を定量測定することにより、非侵襲的に膵癌の悪性度ならびに治療抵抗性の予測を行うことである． 前の先行研究として、膵癌線維化マーカーであるCollagen fiberならびに活性化膵星細胞と予後との関連を後方視的に評価した。手術加療が行われた通常型膵管癌162症例に対してCollagen量を評価するEVG染色、活性化膵星細胞を評価するα-SMA染色を行い評価したところ、Collagen fiberおよびα-SMA陽性細胞が高度の膵癌は生存率が延長する傾向にあった。また線維化高度な膵癌では腫瘍内のCD8陽性T細胞が多いことも判明した。この結果から、膵癌においては線維化が高度な症例で予後が良く、腫瘍内免疫状態とも関連している可能性が示唆された。続いて造影CT平衡相画像から線維化を予測可能かを評価した。線維化予測指標としてECV fractionを利用して38例において評価を行った所、ECV fractionとCollagen fiberの程度に中等度の相関が見られたが（ρ=0.602、P=0.028）、α-SMA陽性細胞との程度には相関は認められなかった（ρ=0.317、P=0.346）。造影CT平衡相における評価は検討症例数を増やすとともに、ヒストグラム解析の追加を検討している。 また膵実質の線維化の有無を造影CT平衡相画像から評価できるかどうかの検討を行った。造影CTから算出されたECV fractionと組織的な膵線維化には相関関係があり（ρ=0.439、P<0.001）、臨床的な術後膵液瘻の予測因子として病変が浸潤癌かどうか、ECV fraction低値であることが多変量解析で判明した。 なお、Dual-Energy CTを用いた膵癌線維性間質の評価を行うための研究に対しては臨床症例の集積を行っており、106例の症例集積が得られたため今後評価を行う。
    競争的資金

  • 祖父江慶太郎, 村上卓道, 上嶋英介, 上野嘉子, 増田充弘
    日本学術振興会 科学研究費助成事業 基盤研究(C), 2019年04月 - 2022年03月
    競争的資金

  • 村上卓道, 鶴崎正勝, 祖父江慶太郎
    日本学術振興会 科学研究費助成事業 基盤研究(C), 2019年04月 - 2022年03月, 研究代表者
    競争的資金

  • 浅井義行, 村上卓道
    日本学術振興会 科学研究費助成事業 基盤研究(C), 2018年04月 - 2021年03月
    競争的資金

  • 甲斐田勇人, 村上卓道, 石井一成, 加藤天美, 伊藤彰彦, 河原明彦, 服部 聡
    日本学術振興会 科学研究費助成事業 基盤研究(C), 2016年04月 - 2021年03月
    競争的資金

  • 鶴﨑正勝, 村上卓道, 祖父江慶太郎
    日本学術振興会 科学研究費助成事業 基盤研究(C), 2017年04月 - 2020年03月
    競争的資金

  • 脂肪定量MRIによるNASHスクリーニング：R2*を用いた至適カットオフ値の検討
    祖父江 慶太郎, 村上 卓道, 鶴崎 正勝
    日本学術振興会, 科学研究費助成事業, 若手研究(B), 神戸大学, 2015年04月01日 - 2019年03月31日
    MRIによる肝の脂肪定量の際に同時に得られるR2*値を利用してGd-EOB-DTPA造影剤の取り込みを定量・数値化できるかどうかの研究を行った． ファントム実験においてはR2*値による造影剤定量は，R1値による造影剤定量とほぼ同等の定量精度が得られることが分かった．臨床研究においては血液生化学的な指標であるMELD scoreやICG 15分停滞率との相関が得られ，R2*値による肝機能定量の有用性が示唆された．一方で，画質の安定性が悪く特に肝左葉では計測値に信頼性が乏しいこと，背景肝実質への過剰鉄沈着例においては定量ができないことが判明し，R2* mapでの肝機能定量における限界と考えられた．

  • 兵頭朋子, 村上卓道, 河野雄輝
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 近畿大学, 2016年04月 - 2019年03月
    目的は、デュアルエナジーCTデータから再構成したヨード密度画像によって、肝細胞癌の肝動脈化学塞栓術(TACE)による局所制御を早期予測しうるかを明らかにすることである。ファントム実験によって、ヨード密度画像では、高濃度ヨードにおいても定量の線形性が保たれ、この点で従来のCT値より優れることが判明した。臨床研究では、ヨード化ケシ油脂肪酸エチルエステルを用いたTACE(Lp-TACE)後のヨード密度画像を用い、画素値のヒストグラム性状を考慮した自動形態解析によって肝細胞癌の局所再発を予測する方法を考案した。形態解析のパラメータは従来の視覚評価に比べ、局所無再発期間との関連性が強かった。

  • 村上卓道, 鶴﨑正勝, 兵頭朋子
    日本学術振興会 科学研究費助成事業 基盤研究(C), 2014年04月 - 2019年03月, 研究代表者
    競争的資金

  • 慢性ウイルス性肝炎の病態把握（重症度・治療介入時期・治療効果判定・予後予測）のための非侵襲的病態診断アルゴリズムの確立
    工藤正俊, 村上卓道
    日本医療研究開発機構, 感染症実用化研究事業 肝炎等克服実用化研究事業, 近畿大学, 2014年04月 - 2017年03月

  • 認知症早期診断のための画像検査実現に向けたPET アミロイドイメージングおよび糖代謝撮像・MRI 形態撮像の統合手法の開発
    木村裕一, 村上卓道, 石井一成, 細川知紗, 岡田志麻
    近畿大学, 21世紀研究開発奨励金, 近畿大学, 2015年04月 - 2016年03月

  • PET、MRIを用いた画像統合解析による変性性認知症の病態解明ならびに早期診断法の開発
    石井一成, 村上卓道, 楠 進, 三井良之, 白川 治, 花田一志
    近畿大学, 21世紀研究開発奨励金, 近畿大学, 2011年04月 - 2014年03月

  • 石井一成, 村上卓道, 熊野正士, 岡田真広
    日本学術振興会 科学研究費助成事業 基盤研究(C), 2011年04月 - 2014年03月
    競争的資金

  • 慢性ウイルス性肝疾患の非侵襲的線維化評価法の開発と臨床的有用性の確立
    工藤正俊, 村上卓道
    厚生労働科学研究費補助金, 難病・がん等の疾患分野の医療の実用化研究事業（肝炎関係研究分野）, 近畿大学, 2011年04月 - 2013年03月

  • 医療用X線防御材料の軽量化
    村上卓道, 坂田尚英, 松本 守
    研究成果展開事業, 研究成果最適展開支援プログラム（A-STEP）, 近畿大学, 2011年04月 - 2012年03月

  • MRIガイド下集束超音波治療のための血管樹状構造に基づく肝臓三次元動態追尾
    熊本 悦子, 黒田 輝, 村上 卓道, 國領 大介
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2010年 - 2012年
    MR ガイド下集束超音波治療においては MRI の持つ軟部組織識別能力と温度分布画像化能力を組み合わせて用いることができるが,これまで比較的動きの少ない子宮筋腫などに用いられてきた.本研究課題では,肝臓の呼吸性移動・変形について MR マルチスライス画像およびステレオスコピック画像を用いて解析した.さらに,その知見に基づき,肝臓の組織の移動・変形にしたがって集束超音波の照射点を追尾する手法を提案しその有効性を示した.

  • 慢性障害肝に発生する乏血性結節の多段階発癌予測に関する実証的研究：肝特異性造影剤Gd-EOB-DTPA造影MRIを用いて
    兵頭朋子, 岡田真広, 村上卓道
    大阪対ガン協会, ガン研究助成奨励金, 近畿大学, 2010年04月 - 2011年03月

  • 工藤正俊, 宗像 浩, 村上卓道, 福永豊和
    日本学術振興会 科学研究費助成事業 基盤研究(B), 2006年04月 - 2009年03月
    競争的資金

  • 黒田 輝, 村上卓道
    日本学術振興会 科学研究費助成事業 基盤研究(C), 2006年04月 - 2009年03月
    競争的資金

  • 八木哲也, 堀 雅敏, 村上 卓道
    日本学術振興会 科学研究費助成事業 特定領域研究, 2005年04月 - 2007年03月
    競争的資金

  • 八木哲也, 堀 雅敏, 村上 卓道
    日本学術振興会 科学研究費助成事業 特定領域研究, 2004年04月 - 2005年03月
    競争的資金

  • 悪性腫瘍に対する高周波熱凝固療法の新しい治療展開：腫瘍内磁性体注入による抗腫瘍効果の増強
    谷川 昇, 澤田 敏, 村上卓道
    日本私立学校振興共済事業団, 大学院教育研究特別経費, 大阪大学, 2003年04月 - 2004年03月

  • 術中における多次元画像の獲得と利用
    田村進一, 橋本昭洋, 中村仁信, 佐藤嘉伸, 中島義和, 中本将彦, 笹間俊彦, 萩原兼一, 藤本典幸, 伊野文彦, 竹村治雄, 鳥脇純一郎, 森 健策, 目加田慶人, 平野 靖, 上甲 剛, 村瀬研也, 小縣裕二, 窪田英明, 村上卓道, 堀 雅敏, 田中 寿, 中西克之, 友田 要, 玉木康博, 田村 学
    日本学術振興会, 未来開拓学術研究推進事業研究プロジェクト, 大阪大学, 1999年04月 - 2003年03月

  • マルチスライスCTの低線量化への応用研究
    中村仁信, 村上卓道, 上甲 剛, 鳴海善文
    文部科学省科学技術振興事業団, 計算科学技術活用型特定研究開発推進事業, 大阪大学, 2000年04月 - 2001年03月

  • 前田宗宏, 高橋 哲, 岡田篤哉, 富山憲幸, 村上卓道, 濱田星紀, 津田 恭, 内藤博昭
    日本学術振興会 科学研究費助成事業 基盤研究(C), 1999年04月 - 2001年03月
    競争的資金

  • 村上卓道
    日本学術振興会 科学研究費助成事業 奨励研究(A), 1999年04月 - 2000年03月, 研究代表者
    競争的資金

  • 村上卓道
    日本学術振興会 科学研究費助成事業 奨励研究(A), 1997年04月 - 1998年03月, 研究代表者
    競争的資金

  • 中村仁信, 鳴海善文, 友田 要, 村上卓道
    日本学術振興会 科学研究費助成事業 奨励研究(A), 1996年04月 - 1997年03月
    競争的資金

  • 村上卓道
    日本学術振興会 科学研究費助成事業 奨励研究(A), 1996年04月 - 1997年03月, 研究代表者
    競争的資金

  • 腹部放射線診断支援治療
    その他の研究制度
    競争的資金

  • 腹部放射線診断学
    その他の研究制度
    競争的資金

  • Interventional Radiology of Abdominal Disease
    The Other Research Programs
    競争的資金

  • Dignostic Radiology of abdominal Disease
    The Other Research Programs
    競争的資金

■ 産業財産権
  • 医療用画像の領域抽出方法
    特許第3486615号
    特許権

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