SEARCH
検索詳細
牧田 快大学院国際文化学研究科 グローバル文化専攻講師
研究活動情報
■ 論文- AIM: Previous studies have reported atypical sensory responses in individuals with autism spectrum disorder (ASD) and their implications for social touch. Although adults with ASD often report discomfort with being touched by others, their preferences for the physical properties of objects are less well understood. In a prior study, we observed that, in typically developed (TD) adults, compliance (a physical correlate of softness) increased tactile pleasantness for deformable surfaces up to levels comparable to those of human body parts. In the present study, we conducted psychophysical experiments to test whether individuals with ASD show atypical affective responses to soft objects resembling human body parts. METHODS: Thirty-six adults with ASD and 36 TD adults numerically estimated the perceived pleasantness or softness while lightly pressing urethane rubbers with their right index fingers. RESULTS: The results revealed that pleasantness increased as a function of compliance, but this increase was significantly smaller for patients with ASD than TD adults, particularly at compliance levels including human body parts. However, the perceived softness increased as a function of compliance highly similarly between the ASD and TD groups. CONCLUSIONS: These findings demonstrate an atypical preference of individuals with ASD for soft objects such as human body parts, which may help explain their tendency to avoid social touch.2025年03月, Psychiatry and clinical neurosciences, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Abstract Childhood maltreatment is reportedly associated with atypical gray matter structures in the primary visual cortex (V1). This study explores the hypothesis that retinal structures, the sensory organs of vision, are associated with brain atypicality and child maltreatment and examines their interrelation. General ophthalmologic examinations, visual cognitive tasks, retinal imaging, and structural magnetic resonance imaging (MRI) were conducted in children and adolescents aged 9–18 years with maltreatment experiences (CM) and typically developing (TD) children. The retinal nerve fiber layer (RNFL), the most superficial of the ten distinct retinal layers, was found to be significantly thinner in both eyes in CM. While whole-brain analysis using Voxel-based morphometry revealed a significantly larger gray matter volume (GMV) in the thalamus in CM, no significant correlation with RNFL thickness was observed. However, based on region-of-interest analysis, a thinner RNFL was associated with a larger GMV in the right V1. Although it cannot be ruled out that this outcome resulted from maltreatment alone, CM demonstrated subclinical structural atypicality in the retina, which may also correlate with the immaturity of V1 development. Examination of retinal thickness offers a novel clinical approach to capturing characteristics associated with childhood maltreatment.Springer Science and Business Media LLC, 2024年05月, Scientific Reports, 14(1) (1)[査読有り]研究論文（学術雑誌）
- 2024年04月, NeuroImage[査読有り]研究論文（学術雑誌）
- 2023年10月, The Journal of Child & Brain Development, 英語[査読有り]研究論文（大学，研究機関等紀要）
- Introduction Infant stimuli attract caregiver attention and motivate parenting behavior. Studies have confirmed the existence of attentional bias toward infant face stimuli; however, relatively little is known about whether attentional bias exists for infant cry stimuli, which are as important as faces in child-rearing situations. Furthermore, scarce longitudinal evidence exists on how attentional bias toward infant crying changes through the postpartum period. Methods In the present study, we conducted an experiment to assess bias toward infant crying at two postpartum time points: at Time 1 (Mean = 75.24 days), 45 first-time mothers participated and at Time 2 (Mean = 274.33 days), 30 mothers participated. At both time points, the mothers participated in a Stroop task with infant crying and white noise as the stimuli. They were instructed to answer the color out loud as quickly and accurately as possible, while ignoring the sound. Four types of audio stimuli were used in this task (the cry of the mother’s own infant, the cry of an unfamiliar infant, white noise matched to the cry of the mother’s own infant, and white noise matched to the cry of an unfamiliar infant), one of which was presented randomly before each trial. Response time and the correct response rate for each condition were the dependent variables. Results For response time, the main effect of familiarity was significant, with longer response times when the participant’s infant’s cry was presented. In addition, response times were lower at Time 2 than at Time 1 in some conditions in which crying was presented. Discussion The results suggest that mothers may be less disturbed by infant crying as they gain more experience. Elucidating the characteristics of postpartum mothers’ changes in cognitive performance related to infants’ cries would be useful in fundamental and applied research to understand the process of parents’ adaptation to parenting.Frontiers Media SA, 2023年09月, Frontiers in Behavioral Neuroscience, 17, 1192275[査読有り]研究論文（学術雑誌）
- 2023年05月, Biol. Psychiatry, 93(9, Supplement) (9, Supplement), S103, 英語[査読有り]
- BACKGROUND: Methylphenidate, a first-line treatment for attention-deficit/hyperactivity disorder (ADHD), is thought to influence dopaminergic neurotransmission in the nucleus accumbens (NAc) and its associated brain circuitry, but this hypothesis has yet to be systematically tested. METHODS: We conducted a randomized, placebo-controlled, double-blind crossover trial including 27 children with ADHD. Children with ADHD were scanned twice with resting-state functional magnetic resonance imaging under methylphenidate and placebo conditions, along with assessment of sustained attention. We examined spontaneous neural activity in the NAc and the salience, frontoparietal, and default mode networks and their links to behavioral changes. Replicability of methylphenidate effects on spontaneous neural activity was examined in a second independent cohort. RESULTS: Methylphenidate increased spontaneous neural activity in the NAc and the salience and default mode networks. Methylphenidate-induced changes in spontaneous activity patterns in the default mode network were associated with improvements in intraindividual response variability during a sustained attention task. Critically, despite differences in clinical trial protocols and data acquisition parameters, the NAc and the salience and default mode networks showed replicable patterns of methylphenidate-induced changes in spontaneous activity across two independent cohorts. CONCLUSIONS: We provide reproducible evidence demonstrating that methylphenidate enhances spontaneous neural activity in NAc and cognitive control networks in children with ADHD, resulting in more stable sustained attention. Our findings identified a novel neural mechanism underlying methylphenidate treatment in ADHD to inform the development of clinically useful biomarkers for evaluating treatment outcomes.2023年05月, Biological psychiatry: Cognitive neuroscience and neuroimaging, 8(3) (3), 271 - 280, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2023年04月, Brain Imaging and Behavior, 17, 436 - 449, 英語[査読有り]研究論文（学術雑誌）
- 2023年04月, Developmental Cognitive Neuroscience, 60, 101209[査読有り]研究論文（学術雑誌）
- Reactive attachment disorder (RAD) is associated with socially and emotionally withdrawn/inhibited behaviors and reduced neural responses to rewards. Children and adolescents with RAD show aberrant attachment behaviors, and existing psychotherapies are difficult to maintain; therefore, pharmacological interventions to aid and boost treatment responses are needed. Oxytocin (OT) administration is known to promote reward functioning. We investigated whether single-use intranasal OT administration improved neural responses during reward processing in patients with RAD compared with healthy controls. Twenty-four male children and adolescents with RAD (10–18 years old) and 27 age- and sex-matched typically developing individuals (10–17 years old) were included in this randomized, double-blind, placebo-controlled, cross-over, functional magnetic resonance imaging study. Following a single intranasal OT (24 IU) or placebo administration, neural responses were investigated using a monetary reward task. In the RAD group, OT significantly increased subjective motivation scores, significantly enhanced activation in the right middle frontal gyrus, and reduced activation in the right precentral gyrus during the monetary reward task. Additional analyses revealed increased activation in the bilateral caudate at a more lenient threshold. Under placebo conditions, the severity of internalizing problems in patients with RAD was negatively correlated with ventral striatal activity. Moreover, the effect of OT on ventral striatum activity was positively associated with the severity of internalizing problems in patients with RAD. Intranasal OT administration enhanced activity in the reward pathway in male children and adolescents with RAD, suggesting that exogenous OT promotes reward processing and reward-related motivational behavior in these individuals. Further investigation is needed to fully understand the neural mechanisms of intranasal OT and identify novel targets for pediatric cases with RAD. Clinical trial registration: UMIN-CTR; UMIN000013215. URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000015419Frontiers Media SA, 2023年01月, Frontiers in Child and Adolescent Psychiatry, 1, 1056115, 英語[査読有り]研究論文（学術雑誌）
- Abstract A large longitudinal study on the impact of the COVID-19 pandemic on mental health in children is limited. This large-scale longitudinal observational study examines the pandemic’s effects on children’s mental health while considering the effects of parental care styles. The Adolescent Brain Cognitive Development Study is a large-scale, longitudinal multicenter study in the United States. Of the 11,875 children aged 9–12 years in its database, 4702 subjects were selected for this study. The child behavior checklist and parental monitoring questionnaire (PMQ) were used to assess children’s mental health and parental support styles, respectively. Data collected before and during the pandemic were compared. Withdrawn/depressed and attention problems significantly worsened during compared to before the COVID-19 pandemic (p < 0.001, withdrawn/depressed; 53.4 ± 5.7 to 53.7 ± 5.9, attention problems; 53.4 ± 5.4 to 53.6 ± 5.6). However, the T scores are in the normal range both before and during the crisis. Simple slope analysis found withdrawn/depressed problems and aggressive behavior worsened when the PMQ was 1 SD below the mean, and rule-breaking behavior was improved when the PMQ was 1 SD above the mean. While the COVID-19 pandemic exacerbated children’s depressive symptoms and attention issues, the effects may be minor. Additionally, parental involvement serve as a protective factor for the child’s mental health even during the pandemic.Springer Science and Business Media LLC, 2022年11月, Scientific Reports, 12, 19601[査読有り]研究論文（学術雑誌）
- Attention ability is one of the most important cognitive functions. It develops mainly during school age. However, the neural basis for the typical development of attentional functions has not been fully investigated. To clarify the development of the aforementioned function and its neural basis, this study examined brain function in children and adolescents during the performance of an attention network test (ANT) using functional magnetic resonance imaging. One hundred and sixty-three volunteers (8-23 years, 80 female) participated in this study. Using a modified version of ANT, we assessed the efficiency of two attentional functions-orienting and executive attention-by measuring how reaction time is affected by spatial cue location and flanker congruency and examined the functional brain areas-attentional networks-associated with two attentional functions. Consistent with the findings of previous studies, the superior parietal lobule, visual association cortex, left precentral gyrus, and supplementary motor area were activated during the orienting attention, while the anterior cingulate cortex, visual association cortex, lateral prefrontal cortex, thalamus, and caudate were activated during the executive attention. Moreover, negative correlations with age were found for activations in the inferior frontal gyrus, dorsomedial prefrontal cortex, and caudate nucleus in the orienting attention, while no correlations with age related to executive attention were found. In conclusion, this study revealed common and distinct features in the neural basis of the attentional functions in children and adolescents compared with that of adults and their developmental changes with age.2022年06月, Neuropsychopharmacology reports, 42(2) (2), 191 - 198, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Methylphenidate is a widely used first-line treatment for attention deficit/hyperactivity disorder (ADHD), but the underlying circuit mechanisms are poorly understood. Here we investigate whether a single dose of osmotic release oral system methylphenidate can remediate attention deficits and aberrancies in functional circuit dynamics in cognitive control networks, which have been implicated in ADHD. In a randomized placebo-controlled double-blind crossover design, 27 children with ADHD were scanned twice with resting-state functional MRI and sustained attention was examined using a continuous performance task under methylphenidate and placebo conditions; 49 matched typically-developing (TD) children were scanned once for comparison. Dynamic time-varying cross-network interactions between the salience (SN), frontoparietal (FPN), and default mode (DMN) networks were examined in children with ADHD under both administration conditions and compared with TD children. Methylphenidate improved sustained attention on a continuous performance task in children with ADHD, when compared to the placebo condition. Children with ADHD under placebo showed aberrancies in dynamic time-varying cross-network interactions between the SN, FPN and DMN, which were remediated by methylphenidate. Multivariate classification analysis confirmed that methylphenidate remediates aberrant dynamic brain network interactions. Furthermore, dynamic time-varying network interactions under placebo conditions predicted individual differences in methylphenidate-induced improvements in sustained attention in children with ADHD. These findings suggest that a single dose of methylphenidate can remediate deficits in sustained attention and aberrant brain circuit dynamics in cognitive control circuits in children with ADHD. Findings identify a novel brain circuit mechanism underlying a first-line pharmacological treatment for ADHD, and may inform clinically useful biomarkers for evaluating treatment outcomes.2022年05月, NeuroImage, 257, 119332 - 119332, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2022年03月, Frontiers in Neurology, 13, 782479, 英語[査読有り]研究論文（学術雑誌）
- The present study examined the relationship between DNA methylation differences and variations in brain structures involved in the development of attention-deficit hyperactivity disorder (ADHD). First, we used monozygotic (MZ) twins discordant (2 pairs of 4 individuals, 2 boys, mean age 12.5 years) for ADHD to identify candidate DNA methylation sites involved in the development of ADHD. Next, we tried to replicate these candidates in a case-control study (ADHD: N = 18, 15 boys, mean age 10.0 years; Controls: N = 62, 40 boys, mean age 13.9 years). Finally, we examined how methylation rates at those sites relate to the degree of local structural alterations where significant differences were observed between cases and controls. As a result, we identified 61 candidate DNA methylation sites involved in ADHD development in two pairs of discordant MZ twins, among which elevated methylation at a site in the sortilin-related Vps10p domain containing receptor 2 (SorCS2) gene was replicated in the case-control study. We also observed that the ADHD group had significantly reduced gray matter volume (GMV) in the precentral and posterior orbital gyri compared to the control group and that this volume reduction was positively associated with SorCS2 methylation. Furthermore, the reduced GMV regions in children with ADHD are involved in language processing and emotional control, while SorCS2 methylation is also negatively associated with emotional behavioral problems in children. These results indicate that SorCS2 methylation might mediate a reduced GMV in the precentral and posterior orbital gyri and therefore influence the pathology of children with ADHD.2022年01月, Frontiers in neuroscience, 15, 799761 - 799761, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Japanese English learners have difficulty speaking Double Object (DO; give B A) than Prepositional Object (PO; give A to B) structures which neural underpinning is unknown. In speaking, syntactic and phonological processing follow semantic encoding, conversion of non-verbal mental representation into a structure suitable for expression. To test whether DO difficulty lies in linguistic or prelinguistic process, we conducted functional magnetic resonance imaging. Thirty participants described cartoons using DO or PO, or simply named them. Greater reaction times and error rates indicated DO difficulty. DO compared with PO showed parieto-frontal activation including left inferior frontal gyrus, reflecting linguistic process. Psychological priming in PO produced immediately after DO and vice versa compared to after control, indicated shared process between PO and DO. Cross-structural neural repetition suppression was observed in occipito-parietal regions, overlapping the linguistic system in pre-SMA. Thus DO and PO share prelinguistic process, whereas linguistic process imposes overload in DO.2022年01月, Frontiers in human neuroscience, 15, 753245 - 753245, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Child maltreatment dysregulates the brain's oxytocinergic system, resulting in dysfunctional attachment patterns. However, how the oxytocinergic system in children who are maltreated (CM) is epigenetically affected remains unknown. We assessed differences in salivary DNA methylation of the gene encoding oxytocin (OXT) between CM (n = 24) and non-CM (n = 31), alongside its impact on brain structures and functions using multi-modal brain imaging (voxel-based morphometry, diffusion tensor imaging, and task and resting-state functional magnetic resonance imaging). We found that CM showed higher promoter methylation than non-CM, and nine CpG sites were observed to be correlated with each other and grouped into one index (OXTmi). OXTmi was significantly negatively correlated with gray matter volume (GMV) in the left superior parietal lobule (SPL), and with right putamen activation during a rewarding task, but not with white matter structures. Using a random forest regression model, we investigated the sensitive period and type of maltreatment that contributed the most to OXTmi in CM, revealing that they were 5-8 years of age and physical abuse (PA), respectively. However, the presence of PA (PA+) was meant to reflect more severe cases, such as prolonged exposure to multiple types of abuse, than the absence of PA. PA+ was associated with significantly greater functional connectivity between the right putamen set as the seed and the left SPL and the left cerebellum exterior. The results suggest that OXT promoter hypermethylation may lead to the atypical development of reward and visual association structures and functions, thereby potentially worsening clinical aspects raised by traumatic experiences.2021年11月, Translational psychiatry, 11(1) (1), 589 - 589, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2020年11月, Scientific Reports, 10(1) (1), Article number - 18903, 英語[査読有り]研究論文（学術雑誌）
- 2020年10月, Journal of Neural Engineering, 17(5) (5)[査読有り]研究論文（学術雑誌）
- 2020年10月, Journal of the American Academy of Child & Adolescent Psychiatry, 59(10(Supplement)) (10(Supplement)), S164 - S165, 英語研究論文（国際会議プロシーディングス）
- Childhood maltreatment is associated with altered brain structure and function and is a major risk factor for psychopathology, including reactive attachment disorder (RAD). However, whether changes to white matter microstructural integrity are associated with RAD is unclear. We used diffusion tensor imaging (DTI) to assess group differences in fractional anisotropy (FA) in patients with RAD (n = 25; mean age = 13.2) to typically developing (TD) controls (n = 33; mean age = 13.0). To further interpret differences in FA, additional parameters such as mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) were assessed. We found that FA values in the body of corpus callosum (CC) and in the projection and thalamic pathways, including the posterior limb of the internal capsule and corona radiata (anterior, posterior, and superior), were significantly higher in the RAD than in the TD group. Additionally, RAD group showed significantly lower RD values in the body of the CC and abovementioned pathways than TD group. Our findings indicate that RAD is associated with altered structure of the CC and projection and thalamic pathways, which may play a role in emotion regulation. The aberrant development of these tracts in RAD may reflect stress-related psychophysiological responses.Elsevier BV, 2020年09月, Psychiatry research. Neuroimaging, 303, Article number - 111129, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- OBJECTIVES: Multiple facets of human emotion underlie diverse and sparse neural mechanisms. Among the many existing models of emotion, the two-dimensional circumplex model of emotion is an important theory. The use of the circumplex model allows us to model variable aspects of emotion; however, such momentary expressions of one's internal mental state still lacks a notion of the third dimension of time. Here, we report an exploratory attempt to build a three-axis model of human emotion to model our sense of anticipatory excitement, "Waku-Waku" (in Japanese), in which people predictively code upcoming emotional events. APPROACH: Electroencephalography (EEG) data were recorded from 28 young adult participants while they mentalized upcoming emotional pictures. Three auditory tones were used as indicative cues, predicting the likelihood of the valence of an upcoming picture: positive, negative, or unknown. While seeing an image, the participants judged its emotional valence during the task and subsequently rated their subjective experiences on valence, arousal, expectation, and Waku-Waku immediately after the experiment. The collected EEG data were then analyzed to identify contributory neural signatures for each of the three axes. MAIN RESULTS: A three-axis model was built to quantify Waku-Waku. As expected, this model revealed the considerable contribution of the third dimension over the classical two-dimensional model. Distinctive EEG components were identified. Furthermore, a novel brain-emotion interface was proposed and validated within the scope of limitations. SIGNIFICANCE: The proposed notion may shed new light on the theories of emotion and support multiplex dimensions of emotion. With the introduction of the cognitive domain for a brain-computer interface, we propose a novel brain-emotion interface. Limitations of the study and potential applications of this interface are discussed.2020年07月, Journal of neural engineering, 17(3) (3), Article number - 036011, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Oxford University Press (OUP), 2020年04月, Cerebral Cortex Communications, 1(1) (1), 1 - 13, 英語
Abstract The lateral occipitotemporal cortex (LOTC) that responds to human bodies and body parts has been implicated in social development and neurodevelopmental disorders like autism spectrum disorder (ASD). Neuroimaging studies using a representational similarity analysis (RSA) revealed that body representation in the LOTC of typically developing (TD) adults is categorized into 3 clusters: action effector body parts, noneffector body parts, and face parts. However, its organization of younger people (i.e., children and adolescents) and its association with individual traits remain unclear. In this functional MRI study, TD adults and children/adolescents observed photographs of hands, feet, arms, legs, chests, waists, upper/lower faces, the whole body, and chairs. The univariate analysis showed that fewer child/adolescent participants showed left LOTC activation in response to whole-body images (relative to those of chairs) than adult participants. Contrastingly, the RSA on both age groups revealed a comparable body representation with 3 clusters of body parts in the bilateral LOTC. Hence, this result indicates that, although response to whole-body images can differ, LOTC body part representations for children/ adolescents and adults are highly similar. Furthermore, sensory atypicality is associated with spatial LOTC organization, suggesting the importance of this region for understanding individual difference, which is frequently observed in ASD.[査読有り]研究論文（学術雑誌） - Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) share high rates of comorbidity, with the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition now acknowledging the comorbid diagnosis of ASD and ADHD. Although structural abnormalities in the prefrontal cortex, cerebellum, and basal ganglia occur in both ASD and ADHD, no structural studies have focused exclusively on patients with comorbid ASD and ADHD. We thus aimed to clarify the structural features and developmental changes in patients with comorbid ASD and ADHD in a relatively large sample from two sites. Ninety-two patients were age-matched to 141 typically developing (TD) controls (age range: 5-16 years) and assessed for volumetric characteristics using structural magnetic resonance imaging (i.e. surface-based morphometry). While there were no significant differences in prefrontal cortex, cerebellum, and basal ganglia volumes, patients with ASD and ADHD exhibited significantly lower left postcentral gyrus volumes than TD controls. We observed significantly lower postcentral gyrus volumes exclusively in children and preadolescents, and not in adolescents. Our findings suggest that abnormal somatosensory, attributed to delayed maturation of the left postcentral gyrus, leads to the core symptoms experienced by patients with comorbid ASD and ADHD.2019年12月, Translational psychiatry, 9(1) (1), Article number - 332, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Informa UK Limited, 2018年10月, Social neuroscience, 14(5) (5), 618 - 630[査読有り]研究論文（学術雑誌）
- 2018年10月, Social neuroscience, 13(5) (5), 1 - 13, 英語[査読有り]研究論文（学術雑誌）
- Using appropriate stimuli to evoke emotions is especially important for researching emotion. Psychologists have provided several standardized affective stimulus databases-such as the International Affective Picture System (IAPS) and the Nencki Affective Picture System (NAPS) as visual stimulus databases, as well as the International Affective Digitized Sounds (IADS) and the Montreal Affective Voices as auditory stimulus databases for emotional experiments. However, considering the limitations of the existing auditory stimulus database studies, research using auditory stimuli is relatively limited compared with the studies using visual stimuli. First, the number of sample sounds is limited, making it difficult to equate across emotional conditions and semantic categories. Second, some artificially created materials (music or human voice) may fail to accurately drive the intended emotional processes. Our principal aim was to expand existing auditory affective sample database to sufficiently cover natural sounds. We asked 207 participants to rate 935 sounds (including the sounds from the IADS-2) using the Self-Assessment Manikin (SAM) and three basic-emotion rating scales. The results showed that emotions in sounds can be distinguished on the affective rating scales, and the stability of the evaluations of sounds revealed that we have successfully provided a larger corpus of natural, emotionally evocative auditory stimuli, covering a wide range of semantic categories. Our expanded, standardized sound sample database may promote a wide range of research in auditory systems and the possible interactions with other sensory modalities, encouraging direct reliable comparisons of outcomes from different researchers in the field of psychology.2018年08月, Behavior research methods, 50(4) (4), 1415 - 1429, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Elsevier Ireland Ltd, 2018年07月, Neuroscience Research, 132, 37 - 45, 英語[査読有り]研究論文（学術雑誌）
- 2017年05月, FRONTIERS IN HUMAN NEUROSCIENCE, 11, Article number - 00232, 英語[査読有り]研究論文（学術雑誌）
- 2017年02月, SCIENTIFIC REPORTS, 7, Article number - 40931, 英語[査読有り]研究論文（学術雑誌）
- Japanese Society for Physiological Psychology and Psychophysiology, 2016年12月, 生理心理学と精神生理学, 34(1) (1), 53 - 60, 日本語[査読有り]研究論文（学術雑誌）
- 2016年11月, Frontiers in Psychology, 7, Article number - 1763, 英語[査読有り]研究論文（学術雑誌）
- 2016年04月, Scientific Reports, 6, Article number - 24561, 英語[査読有り]研究論文（学術雑誌）
- 2016年03月, SOCIAL NEUROSCIENCE, 11(2) (2), 109 - 122, 英語[査読有り]研究論文（学術雑誌）
- 2015年08月, NEUROSCIENCE, 300, 474 - 492, 英語[査読有り]研究論文（学術雑誌）
- 2013年12月, MIND BRAIN AND EDUCATION, 7(4) (4), 213 - 224, 英語[査読有り]研究論文（学術雑誌）
- 2023年, 日本心理学会大会発表抄録集, 86thDNAメチル化と乳児泣き声に対する脳活動の関連
- 2023年, 日本精神神経学会総会プログラム・抄録集, 119thASDの非定型的な触覚の特徴と社会性の関連
- 2022年, 日本赤ちゃん学会学術集会抄録集(CD-ROM), 22nd産後2時点における乳児の泣き声に対する脳活動の変化
- 2021年, 日本発達心理学会大会プログラム(CD-ROM), 32nd反応性愛着障害の症状スクリーニング 日本語版愛着関係問題質問票(RPQ-J)の開発
- 2021年, 臨床薬理の進歩, (42) (42)児童青年期の反応性愛着障害におけるオキシトシン点鼻投与の効果-ランダム化二重盲検比較試験-
- 2021年, 日本心理学会大会発表論文集, 85th初産後の母親における乳児の泣き声に対する神経活動と共感性・行動賦活系の関連
- 2021年, 日本赤ちゃん学会学術集会プログラム・要旨集, 21st (CD-ROM)産後うつ傾向と我が子の泣き声に対する注意バイアスの関連
- (一社)日本小児精神神経学会, 2019年11月, 日本小児精神神経学会プログラム・抄録集, 122回, 63 - 63, 日本語反応性愛着障害児における脳白質線維構造解析
- 公益社団法人 日本心理学会, 2019年09月, 日本心理学会大会発表論文集, 83(0) (0), 2D - 015-2D-015, 日本語
- 公益社団法人 日本心理学会, 2019年09月, 日本心理学会大会発表論文集, 83(0) (0), 1A - 074-1A-074, 日本語
- 発達科学研究教育センター, 2019年06月20日, 発達研究 : 発達科学研究教育センター紀要, 33, 175 - 179, 日本語ADHD児の母親に対するペアレント・トレーニングの効果が子どもの実行機能改善に及ぼす影響の予備的検討(中間報告)
- 2019年06月09日, The Organization for Human Brain Mapping Annual Meeting (OHBM 2019), T463, 英語Effects of alloparenting status for brain development in children: Resting-state fMRI study[査読有り]
- (一社)日本児童青年精神医学会, 2018年10月, 日本児童青年精神医学会総会抄録集, 59回, P21 - 4, 日本語親子関係と養育環境が子の安静時脳機能に及ぼす影響
- 金原出版, 2018年06月01日, 小児科 = Pediatrics of Japan, 59(7) (7), 969 - 976, 日本語記事・総説・解説・論説等（学術雑誌）
- 公益社団法人 日本心理学会, 2018年, 日本心理学会大会発表論文集, 82(0) (0), 2PM - 087-2PM-087, 日本語
- 2015年, 日本ヒト脳機能マッピング学会プログラム・抄録集, 17th, 70, 日本語外国語産出能力の習熟過程に関わる大脳基底核の脳活動の可塑的変化
- 運転映像中に提示される視標の検出課題中の脳活動をfMRIによって測定した．実験では，水平線上の5カ所のうち1カ所に視標が提示され，実験協力者はできるだけ早くボタン押しを行った．実験条件は車速(60, 160km/h)×ピラー(垂直，傾斜)の4条件であった．反応時間の分散分析の結果，ピラー傾斜条件で右端（ピラーの外側）の視標検出が有意に遅いことがわかった．視標提示後2秒間の脳活動の分散分析の結果，ピラーと視標提示位置の交互作用が左楔前部に見られ，その活動は右端の視標提示時にピラー傾斜条件で活動が大きかった．先行研究でADHDや自閉症の青年に楔前部の過活動が報告されており，楔前部の活動はピラーの角度によって生じる運転と非関連な情報に注意が捕捉され，より注意のリソースが視標検出に必要になったことを反映していると考えられる．この結果は，脳活動測定を安全な自動車の設計へ利用できる可能性を示している．日本認知心理学会, 2015年, 日本認知心理学会発表論文集, 2015(0) (0), 27 - 27, 日本語
- 2014年10月, 第４回社会神経科学研究会抄録集, 33, 日本語隠喩的表現における面白さと見劣り効果の神経基盤の検討研究発表ペーパー・要旨（全国大会，その他学術会議）
- 日本人英語学習者のL2文産出処理の自動化に伴う神経基盤の変化―fMRI実験による検討―日本人英語学習者を対象にした行動実験により、統語的プライミング率は熟達度により異なることが示され、学習者の熟達化に伴い脳内の統語表象が変化する可能性が示唆されている(Nakagawa, Morishita, & Yokokawa, 2013)。本研究では、第二言語(L2)文産出能力の熟達化に伴う学習者の神経基盤の変化を明らかにするためにfMRI実験を行った。41名の日本人英語学習者が実験に参加し、参加者は提示される絵を見てその内容を口頭で説明することを連続的に行った。実験の結果、低熟達度群の学習者は、構造を持つ文を繰り返し産出するときと直前に構造を産出していないときの脳活動の差が大きく、その差は動作の開始に関わるとされる前帯状皮質においてみられた。一方、高熟達度群の学習者はその差が小さかった。このことは、第二言語運用能力の熟達化に伴い文産出の開始にかかる負荷が軽減される可能性を示唆している。一般社団法人電子情報通信学会, 2013年12月14日, 電子情報通信学会技術研究報告, 113(354(TL2013 47-60)) (354(TL2013 47-60)), 59 - 64, 日本語
- 2013年11月, 第３回社会神経科学研究会抄録集, 25, 日本語隠喩的表現における面白さの情動生起の神経基盤の検討研究発表ペーパー・要旨（全国大会，その他学術会議）
- 岐阜聖徳学園大学, 2013年, 岐阜聖徳学園大学教育実践科学研究センター紀要, (13) (13), 107 - 111, 日本語データに基づく文章構成スキルの習熟について : アカデミック・ライティング指導から
- cognitivesciencesociety.org, 2012年, Proceedings of the 34th Annual Meeting of the Cognitive Science Society, CogSci 2012, Sapporo, Japan, August 1-4, 2012The Role of the Amygdala in the Process of Humour Appreciation.[査読有り]
- 2012年, 日本ヒト脳機能マッピング学会プログラム・抄録集, 14th, 67, 日本語第二言語音声処理の自動化に関わる前頭前野二領域の脳活動の可塑的変化
- 2011年10月, 第１回社会神経科学研究会抄録集, 49, 日本語隠喩的表現における面白さと関連性の神経基盤の検討研究発表ペーパー・要旨（全国大会，その他学術会議）
- 未知語の模倣と反復による語彙学習の神経基盤と自動化プロセス本研究は,模倣と反復を取り入れた学習法における脳活動の神経基盤を解明することにある.そのために,fMRIを用いて,未知語の模倣と観察時における脳活動の変化を調べた.その結果,模倣と観察のいずれにおいても,反復回数の増加に伴って左腹側運動前野(BA6)からブローカ領域(BA44)の神経活動が低減した.この所見は,音声模倣学習の神経基盤が左半球前頭葉ミラーニューロン・システムにあることを示唆する.また,反復にともなう反応潜時の減少および,反応時間のモデル音長への接近から,学習効果が見られたことと,その後の学習実験より同様の結果が得られたことより,自動化プロセスへの解明の一歩が得られたと判断される.一般社団法人電子情報通信学会, 2009年07月11日, 電子情報通信学会技術研究報告, 109(140(TL2009 8-24)) (140(TL2009 8-24)), 17 - 22, 日本語
- 大阪教育大学教科教育学研究会, 2007年, 教科教育学論集, (6) (6), 93 - 109, 日本語英語教育講座における小学校英語活動サポート活動--北豊島小学校アフタースクールクラブにて
■ 講演・口頭発表等
- The Organization for Human Brain Mapping Annual Meeting 2021, 2021年06月, 英語Empathy and Behavioral Activation System Predict Neural Activation to Infant Crying in New Mothers
- 日本赤ちゃん学会第21回学術集会, 2021年06月, 日本語産後うつ傾向と我が子の泣き声に対する注意バイアスの関連
- 第63回 日本小児神経学会学術集会, 2021年05月, 英語Effects of methylphenidate on aberrant brain network dynamics in children with ADHD
- Society of Biological Psyciatry 2021 Virtual Meeting, 2021年05月, 英語Effects of Methylphenidate on Aberrant Brain Network Dynamics in Children With Attention-Deficit/Hyperactivity Disorder: A Randomized Controlled Clinical Trial
- ⽇本発達⼼理学会第32回⼤会, 2021年03月, 日本語反応性愛着障害の症状スクリーニング－日本語版愛着関係問題質問票（RPQ-J）の開発－
- 第25回 福井大学高エネルギー医学研究センター 研究発表会, 2021年02月, 日本語非侵襲的脳機能画像検査を用いた愛着障害の神経基盤の評価システム～オキシトシン点鼻による脳賦活変化～
- American Academy of Child and Adolescent Psychiatry (AACAP's) Virtual Annual Meeting, 2020年10月, 英語Structural Brain Abnormalities in Children and Adolescents with Comorbid Autism Spectrum Disorder
- 第62回日本小児神経学会学術集会, 2020年08月, 英語White matter tract abnormalities in children with reactive attachment disorder
- 第45回北米神経科学会年次総会, 2015年10月, 英語, 国際会議"Personality Traits Predict Insular Activation during Anticipation of Affective Pictures: an fMRI study."ポスター発表
- 第43回北米神経科学会年次総会, 2013年11月, 英語, 国際会議"The impact of second language proficiency on an automatic process of written words: an fMRI study."ポスター発表
- 第41回北米神経科学会年次総会, 2011年11月, 英語, 国際会議“The role of the right cerebellum during foreign language vocabulary learning enhanced by the phonological loop: an fMRI study.”ポスター発表
■ 共同研究・競争的資金等の研究課題
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 福井大学, 2021年04月01日 - 2025年03月31日不適切養育が子どもの心の発達に及ぼす影響：多角的手法による生物学的基盤の解明不適切養育（虐待やネグレクト等）を経験することで，神経発達症様の症状やトラウマ関連障害の症状が発現するリスクが高まり，多動性障害，気分障害，人格障害などの重篤な精神疾患へ推移していく可能性もある。このような症状は，重症化率，併存率も高く，治療応答性が低い。よってこのような子どもには，より早期の対応が望ましく，教育社会面での支援が急務である。しかし，現状では不適切養育を背景要因としたこのような疾患様は，そうでない他の発達障害との鑑別困難性から，適切な診断とそれに基づく対応の構築は未だ十分とは言えない。 本研究では，不適切養育を受けた子どもを主な対象とし，認知神経科学，小児発達学，分子生物学の手法を用いて，子どもの心の発達を多角的に，また同じ参加者を複数回計測することで縦断的に検討することを目的としている。計測内容は，質問紙による心理・臨床指標，MRIを用いた脳構造・脳機能データ，唾液採取による生体試料の収集である。本研究から得られる知見は，不適切養育を受けた子どもの心の発達の理解とその対応方策，社会的養育の在り方やその構築方法の確立に寄与するものである。 研究対象は児童青年期の不適切養育下にあった子ども（不適切養育群）と，対照となる子ども（定型群）である。同一対象に対して年１度の頻度で複数回データを収集することにより、横断データのみならず縦断データとしてその発達の過程を計測する。 初年度（令和３年度）は実験内容・実験環境の構築を行い、次年度以降のデータ収集・解析に向けて準備を整えている。
- 日本学術振興会, 科学研究費助成事業 基盤研究(A), 基盤研究(A), 福井大学, 2019年04月01日 - 2023年03月31日愛着障害の新たな客観的診断・支援法の開発ー少子化社会を克服するための戦略ー愛着障害を有する子どもの1）脳MR拡散テンソル画像（DTI）および2）視線計測検出装置による視線パターンによる社会性発達データを取得し、定型発達児を対照に群間解析を行った。その結果は、愛着障害の病態解明および病態特徴に基づいた治療方針の選択等を目指した臨床応用への発展に貢献した。
1）DSM-5の診断基準を満たした愛着障害（反応性アタッチメント障害）児31名（平均年齢：12.7歳）の拡散テンソル画像を用いて大脳白質の神経の走行性を調べてみた。定型発達児41名（平均年齢：12.5歳）と比べて、視床の灰白質容積と視床から前頭葉を繋げる白質線維（Anterior Thalamic Radiations）が増加していた(Jung et al., Cerebral Cortex 2020)。さらに、視床の灰白質容積の増加と臨床病状の評価尺度との関連性を調べたところ、視床の灰白質容積の増加と子どもの問題行動尺度との間に有意な関連性が認められた。今回の検討で、愛着障害児は感覚入力（視覚・聴覚・体性感覚）に重要な役割を担う視床と問題行動との間に関連性が示唆された。 2）乳児院や児童養護施設に入所する被虐待経験のある幼児（マルトリートメント群：以下CM）に視線計測を行った結果、非定型的視線パターンが確認され、社会行動特性との関連性も示唆された(Suzuki et al., Sci Rep 2020)。また社会性に関連すると言われている唾液中オキシトシンホルモン濃度が対照群（一般家庭養育下にあるCM歴のない幼児）に比べて低くその差異が認められ、視線や行動調整に関与している可能性が確認できた。先天的な発達課題に限らず、幼い時期に受けた養育的問題によって生じうる子どもの問題行動や社会性発達の課題を予測する簡便な一手段として、早期発見や早期療育に関連する有益な見解を得た。 - 日本学術振興会, 科学研究費助成事業 若手研究, 若手研究, 福井大学, 2018年04月01日 - 2021年03月31日, 研究代表者発達障害児の養育者の子育て困難の軽減・改善は，養育者の子どもに対する不適切な対応の予防につながる。そのためには発達障害児とその養育者の子育て困難の背景にある生物学的な脆弱性を特定し，子育て困難の軽減・改善に関連したメカニズムの解明が必要である。本研究では，特にADHDを持つ子どもとその養育者の子育て困難に焦点を当て，養育者に対する子育て支援方法であるペアレント・トレーニング（PT）の介入効果と，関連する脳神経科学的基盤の変化を縦断的アプローチにより検討する。 ADHDの診断を受けた児童とその母親が対象である。令和元年度内に，計26組に対してPTによる介入を実施し，開始直前，終了直後に計2回，子育て困難指標とADHD症状，またMRIを用いて脳機能・構造の計測を行った。尚、今回の解析対象は子どもの脳機能画像が取得できた10組で，母親の半数は先行してPTに参加（介入群：6名），残りの半数（待機群：4名）は介入群のPT終了3ヶ月後に改めて参加している。介入前後の変化は，介入群と待機群の比較検討を行った。 結果，PT受講群の母親の養育ストレス指標が有意に減少し，またADHD児の子どもの行動のチェックリストの内，「注意の問題」尺度が有意に減少していた。更にADHD児の脳機能については，受講群の子のみ母親のPT受講後に，受講前よりも前頭回内側部の活動が上昇していた。前頭回内側部は，社会的理解やコミュニケーション，自他の認知に関わることが知られている。これらから，PTによる母親への介入が母親の子に対する理解と養育環境の向上を導き，それにより子の社会的認知の上昇と機能的問題の軽減に結びついたと考えられる。競争的資金
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 生理学研究所, 2008年 - 2010年本研究課題により、未知のものを結びつける学習(対連合学習)をする際の神経システム要素を同定し、その中で特に左腹外側前頭前野(VLPFC)が重要な役割を果たしていることを明らかにした。またシステムの領域間因果性結合解析ツールとしてのDynamic Causal Modeling (DCM)の検証を複数の実験により行い、その有効性を確かめることが出来た。さらに未知の外国語学習の神経基盤について、小脳の関与を明らかにした。
- 脳の島皮質活動抽出方法特願2016-157238, 2016年08月10日, 国立大学法人広島大学, 特開2018-023586, 2018年02月15日, 特許第6742628号, 2020年07月31日特許権
- 乗員の感性向上システム特願2015-246009, 2015年12月17日, 国立大学法人広島大学, マツダ株式会社, 特開2017-109635, 2017年06月22日, 特許第6731718号, 2020年07月09日特許権
- 感性評価方法特願2016-116449, 2016年06月10日, 国立大学法人広島大学, 特開2017-074356, 2017年04月20日, 特許第6590411号, 2019年09月27日, 広島大学特許権
- Sensitivity evaluation method特願US 15/768,782, 2016年08月10日, 広島大学, 特開US 2018,0303370,A1, 2018年10月25日特許権