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OH Tenen
University Hospital / Radiation Oncology
Other

Researcher basic information

■ Research Areas
  • Life sciences / Radiology

Research activity information

■ Paper
  • Ryuji Shimada, Keitaro Sofue, Tianyuan Wang, Takeaki Ishihara, Eisuke Ueshima, Yoshiko Ueno, Akiko Kusaka, Takamichi Murakami
    Cine-magnetic resonance imaging (MRI) has been used to track respiratory-induced motion of the liver and tumor and assist in the accurate delineation of tumor volume. Recent developments in compressed sensitivity encoding (SENSE; CS) have accelerated temporal resolution while maintaining contrast resolution. This study aimed to develop and assess hepatobiliary phase (HBP) cine-MRI scans using CS. Phantom was imaged using cine-MRI and signal intensity (SI) and contrast ratio (CR) measured to determine the optimal flip-angle turbo field echo (TFE) prepulse delay. We performed cine-MRI in 20 patients for one minute, with images taken every 0.5 s after administration of gadoxetic acid contrast agent. Acquired images had three different acceleration factors (SENSE, CS without denoising [CS-no], and CS with strong denoising [CS-strong]). The image quality of the HBP cine MRI was quantitatively and qualitatively analyzed. In the phantom study, a flip angle of 30 °and TFE prepulse delay of 150 ms were optimal for clinical imaging. In a clinical study, CS-strong showed the highest signal-to-noise ratio and comparable contrast ratio among the three sequences. The CS-strong group showed a significantly higher image quality (P < 0.01), except for motion smoothness (P = 0.11). CS with denoising improved the tumor-to-liver contrast and image quality in high-temporal-resolution HBP cine MRI.
    Dec. 2024, Scientific reports, 14(1) (1), 31347 - 31347, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Peter J K Tokuda, Yusuke Demizu, Tianyuan Wang, Nobuyoshi Fukumitsu, Takeshi Suzuki, Sho Kurihara, Eiso Hiyama, Shuhei Karakawa, Yoshiyuki Kosaka, Ryohei Sasaki, Takumi Fukumoto, Masaki Kokubo, Toshinori Soejima
    Space-making particle therapy, which consists of surgical placement of a spacer followed by particle therapy, has become a solution to the problem of normal organs being exposed to a high radiation dose. A bioabsorbable spacer is particularly suitable for this purpose, but is not widely used. Surgical placement of a spacer is performed mostly to protect the digestive tract, but can also be used to protect the kidneys. Therefore, we have been interested in the use of space-making particle therapy to preserve renal function. A 14 month-old boy with intermediate-risk retroperitoneal rhabdomyosarcoma underwent surgery with placement of a bioabsorbable spacer following neoadjuvant chemotherapy and then received proton beam therapy of 41.4 Gy (relative biological effectiveness) in 23 fractions. In the 41 months since PBT, he has survived without local recurrence or signs of renal impairment. This report describes the first-ever case of surgical placement of a bioabsorbable spacer with the aim of preserving renal function during proton beam therapy. Space-making particle therapy is an innovative solution for peritoneal tumors adjacent to the kidneys.
    Oct. 2024, International cancer conference journal, 13(4) (4), 476 - 480, English, International magazine
    Scientific journal

  • Shohei Komatsu, Tianyuan Wang, Kazuki Terashima, Yusuke Demizu, Makoto Anzai, Masaki Suga, Tomohiro Yamashita, Osamu Suzuki, Tomoaki Okimoto, Ryohei Sasaki, Takumi Fukumoto
    BACKGROUND: Particle therapy (PT) has favorable dose distribution and high curability. However, radiotherapy for malignant tumors adjacent to the gastrointestinal tract is contraindicated owing to its low tolerance. To overcome this, combination treatment with surgery to make a space between the tumor and adjacent gastrointestinal tract followed by PT has been developed. Several materials have been used for the spacer, and we have recently developed the absorbable polyglycolic acid (PGA) spacer, which has been used since 2019. This study is the first report of consecutive case series of spacer placement surgery using the PGA spacer. STUDY DESIGN: Fifty consecutive patients undergoing spacer placement surgery with the PGA spacer were evaluated. Postoperative laboratory data, morbidity related to the treatment, and spacer volume after treatment were evaluated. RESULTS: There were no treatment-related deaths, and all but two patients completed combination treatment. The median ratios of post-operative PGA spacer volume to the pre-treatment volume were 96.9%, 87.7%, and 74.6% at weeks 2, 4, and 8, respectively. The spacer volume was maintained at 80% at 7 weeks and was predicted to be 50% at 15 weeks and 20% in 24 weeks. CONCLUSIONS: Spacer placement surgery using the PGA spacer was feasible and tolerable. The PGA spacers maintained sufficient thickness during the duration of subsequent PT. Combination treatment using the PGA spacer is innovative and has the potential to become a new standard curative local treatment.
    Sep. 2023, Journal of the American College of Surgeons, English, International magazine
    Scientific journal

  • Tianyuan Wang, Keitaro Sofue, Ryuji Shimada, Takeaki Ishihara, Ryuichi Yada, Masanori Miyamoto, Ryohei Sasaki, Takamichi Murakami
    To develop and investigate the feasibility of sub-second temporal resolution volumetric T1-weighted four-dimensional (4D-) MRI in comparison with 4D-CT for respiratory-correlated motion assessment using an MRI/CT-compatible phantom. Sub-second high temporal resolution (0.5 s) gradient-echo T1-weighted 4D-MRI was developed using a volumetric acquisition scheme with compressed sensing. An MRI/CT-compatible motion phantom (simulated liver tumor) with three sinusoidal movements of amplitudes and two respiratory patterns was introduced and imaged with 4D-MRI and 4D-CT to investigate the geometric accuracy of the target movement. The geometric accuracy, including centroid position, volume, similarity index of dice similarity coefficient (DSC), and Hausdorff distance (HD), was systematically evaluated. Proposed 4D-MRI achieved a similar geometric accuracy compared with 4D-CT regarding the centroid position, volume, and similarity index. The observed position differences of the absolute average centroid were within 0.08 cm in 4D-MRI and 0.03 cm in 4D-CT, less than the 1-pixel resolution for each modality. The observed volume difference in 4D-MRI/4D-CT was within 0.73 cm3 (4.5%)/0.29 cm3 (2.1%) for a large target and 0.06 cm3 (11.3%)/0.04 cm3 (11.6%) for a small target. The observed DSC values for 4D-MRI/4D-CT were at least 0.93/0.95 for the large target and 0.83/0.84 for the small target. The maximum HD values were 0.25 cm/0.31 cm for the large target and 0.21 cm/0.15 cm for the small target. Although 4D-CT potentially exhibit superior numerical accuracy in phantom studies, the proposed high temporal resolution 4D-MRI demonstrates sub-millimetre geometric accuracy comparable to that of 4D-CT. These findings suggest that the 4D-MRI technique is a viable option for characterizing motion and generating phase-dependent internal target volumes within the realm of radiotherapy.
    Sep. 2023, Scientific reports, 13(1) (1), 15685 - 15685, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 奥村 圭祐, 若山 司, 松田 大志, 松本 賢治, 椋本 成俊, 矢田 隆一, 王 天縁, 西谷 隆治, 日下 亜起子, 武村 哲浩
    (公社)日本放射線技術学会, Sep. 2021, 日本放射線技術学会雑誌, 77(9) (9), 959 - 967, Japanese

  • Keisuke Okumura, Tsukasa Wakayama, Taishi Matsuda, Kenji Matsumoto, Naritoshi Mukumoto, Ryuichi Yada, Tianyuan Wang, Takaharu Nishitani, Akiko Kusaka, Akihiro Takemura
    PURPOSE: For whole-breast irradiation after breast-conserving surgery, computed tomography simulation (CTS) and irradiation are generally performed during free breathing. In treatment planning, there are three techniques: field-in-field (FIF), physical wedge (PW), and enhanced dynamic wedge (EDW). The aim of this study was to investigate the impact of respiratory motion on doses for these three irradiation techniques. METHODS: All doses were measured using an ionization chamber in a cylindrical phantom on a respiratory motion platform. Doses for each technique were measured with and without phantom motion. The dose without phantom motion was defined as the reference. The reference was compared to the dose with the phantom motion. The positions of the isocenter with respect to the ranges of phantom motion were set as exhale and intermediate. The phantom motion amplitude was set to 5 mm or 10 mm. The respiratory phase to initiate irradiation was varied as inhale, intermediate-inhale, exhale and intermediate-exhale. RESULTS: When the motion amplitude was 10 mm, the dose differences for the FIF, PW, and EDW techniques were 4.2%, 0.5%, and 0.8%, respectively, at the maximum. However, the dose difference for the FIF technique was -0.5% when the isocenter position was set to the intermediate phase of phantom motion. CONCLUSION: We found that the dose difference per fraction was reduced when the respiratory phase during CTS image acquisition was set to the intermediate phase. Meanwhile, the dose differences per fraction for the PW and EDW techniques were less affected by the respiratory motion.
    2021, Nihon Hoshasen Gijutsu Gakkai zasshi, 77(9) (9), 959 - 967, Japanese, Domestic magazine
    Scientific journal

  • Ryuichi Yada, Kazusuke Maenaka, Shuji Miyamoto, Go Okada, Aki Sasakura, Motoi Ashida, Masashi Adachi, Tatsuhiko Sato, Tianyuan Wang, Hiroaki Akasaka, Naritoshi Mukumoto, Yasuyuki Shimizu, Ryohei Sasaki
    Aug. 2020, MEDICAL PHYSICS, English
    [Refereed]
    Scientific journal

  • Tianyuan Wang, Sachiko Inubushi, Naoko Ikeo, Keisuke Okumura, Hiroaki Akasaka, Ryuichi Yada, Kenji Yoshida, Daisuke Miyawaki, Takeaki Ishihara, Ai Nakaoka, Toshiji Mukai, Ryohei Sasaki
    PURPOSE: Develop a novel biocompatible solid fiducial marker that prevents radiopaque imaging artifacts and also maintains high imaging contrast for kilovoltage X-ray image-guided radiation therapy. METHODS: The fiducial marker was made of pure zinc. An in-house water-equivalent phantom was designed to evaluate artifacts and visibility under various simulated treatment scenarios. Image artifacts were quantitatively assessed in terms of the metal artifact index (MAI) on kilovoltage computed tomography (CT) and cone-beam CT (CBCT) scans. Marker visibility was evaluated on two types of kilovoltage planar X-ray images in terms of the contrast-to-background ratio (CBR). Comparisons with a conventional gold fiducial marker were conducted. RESULTS: Use of a zinc rather than a gold marker mitigates imaging artifacts. The MAI near the zinc marker decreased by 76, 79, and 77 % in CT, and by 77 (81), 74 (80), and 79 (85) % in CBCT full-fan (half-fan) scans, when using one-, two- and three-marker phantom settings, respectively. The high-contrast part of the zinc marker exhibited CBRs above 2.00 for 28/32 exposures under four (lung, tissue, low-density bone, and high-density bone) different simulation scenarios, making its visibility comparable to that of the gold marker (30/32 exposures with CBRs > 2.00). CONCLUSIONS: We developed a biocompatible, artifact-robust, and highly visible solid zinc fiducial marker. Although further evaluation is needed in clinical settings, our findings suggest its feasibility and benefits for kilovoltage X-ray image-guided radiation therapy.
    Jul. 2020, Medical physics, English, International magazine
    [Refereed]
    Scientific journal

  • Ryuichi Yada, Kazusuke Maenaka, Shuji Miyamoto, Go Okada, Aki Sasakura, Motoi Ashida, Masashi Adachi, Tatsuhiko Sato, Tianyuan Wang, Hiroaki Akasaka, Naritoshi Mukumoto, Yasuyuki Shimizu, Ryohei Sasaki
    2020, Medical Physics
    [Refereed]
    Scientific journal

  • 放射線治療 QOLを考慮した局所治療 小児がんに対する吸収性スペーサー留置を併用した粒子線治療
    佐々木 良平, 出水 祐介, 岩田 宏満, 亀井 美智, 文野 誠久, 赤坂 浩亮, 王 天縁, 妹尾 悟史, 犬伏 祥子, 宮脇 大輔, 吉田 賢史, 小松 昇平, 福本 巧
    (一社)日本小児血液・がん学会, Sep. 2019, 日本小児血液・がん学会雑誌, 56(2) (2), 148 - 152, Japanese
    [Refereed]

  • Ryohei Sasaki, Yusuke Demizu, Tomohiro Yamashita, Shohei Komatsu, Hiroaki Akasaka, Daisuke Miyawaki, Kenji Yoshida, Tianyuan Wang, Tomoaki Okimoto, Takumi Fukumoto
    Elsevier {BV}, May 2019, Advances in Radiation Oncology, 4(4) (4), 729 - 737
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiroaki Akasaka, Naritoshi Mukumoto, Masao Nakayama, Tianyuan Wang, Ryuichi Yada, Yasuyuki Shimizu, Sachiko Inubushi, Katsusuke Kyotani, Keisuke Okumura, Masanori Miyamoto, Ai Nakaoka, Kenta Morita, Yuya Nishimura, Chiaki Ogino, Ryohei Sasaki
    2019, Applied Nanoscience (Switzerland)
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Tianyuan Wang, Takeaki Ishihara, Atsushi Kono, Naoki Yoshida, Hiroaki Akasaka, Naritoshi Mukumoto, Ryuichi Yada, Yasuo Ejima, Kenji Yoshida, Daisuke Miyawaki, Kenichiro Kakutani, Kotaro Nishida, Noriyuki Negi, Toshiaki Minami, Yuuichi Aoyama, Satoru Takahashi, Ryohei Sasaki
    Aug. 2017, PHYSICS IN MEDICINE AND BIOLOGY, 62(15) (15), 6226 - 6245, English
    [Refereed]
    Scientific journal

  • Hiroaki Akasaka, Naritoshi Mukumoto, Masao Nakayama, Tianyuan Wang, Ryuichi Yada, Yasuyuki Shimizu, Saki Osuga, Yuki Wakahara, Ryohei Sasaki
    InTech, May 2017, Radiotherapy
    In book

  • Evaluation of a small animal irradiation system for animal experiments using EBT3 model GAFCHROMIC ™ film
    Yasuyuki Shimizu, Hiroaki Akasaka, Daisuke Miyawaki, Naritoshi Mukumoto, Masao Nakayama, Tianyuan Wang, Saki Osuga, Sachiko Inubushi, Ryuichi Yada, Yasuo Ejima, Kenji Yoshida, Takeaki Ishihara, Ryohei Sasaki
    Jan. 2017, Kobe Journal of Medical Sciences, 63(3) (3), E84 - E91, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Evaluation of a Small Animal Irradiation System for Animal Experiments Using EBT3 Model GAFCHROMIC Film
    SHIMIZU Yasuyuki, AKASAKA Hiroaki, MIYAWAKI Daisuke, MIYAWAKI Daisuke, MUKUMOTO Naritoshi, NAKAYAMA Masao, WANG Tianyuan, OSUGA Saki, INUBUSHI Sachiko, YADA Ryuichi, EJIMA Yasuo, YOSHIDA Kenji, YOSHIDA Kenji, ISHIHARA Takeaki, ISHIHARA Takeaki, SASAKI Ryohei, SASAKI Ryohei
    2017, Kobe Journal of Medical Sciences (Web), 63(3) (3), E84‐E91 (WEB ONLY), English

  • Hiroaki Akasaka, Yoshiyuki Mizushina, Kenji Yoshida, Yasuo Ejima, Naritoshi Mukumoto, Tianyuan Wang, Sachiko Inubushi, Masao Nakayama, Yuki Wakahara, Ryohei Sasaki
    Nov. 2016, RADIATION ONCOLOGY, 11, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

■ MISC
  • 放射線治療 QOLを考慮した局所治療 小児がんに対する吸収性スペーサー留置を併用した粒子線治療
    佐々木 良平, 出水 祐介, 岩田 宏満, 亀井 美智, 文野 誠久, 赤坂 浩亮, 王 天縁, 妹尾 悟史, 犬伏 祥子, 宮脇 大輔, 吉田 賢史, 小松 昇平, 福本 巧
    (一社)日本小児血液・がん学会, Sep. 2019, 日本小児血液・がん学会雑誌, 56(2) (2), 148 - 152, Japanese

  • 小児がんに対する吸収性スペーサー留置を併用した粒子線治療
    佐々木良平, 出水祐介, 岩田宏満, 亀井美智, 文野誠久, 赤坂浩亮, 王天縁, 妹尾悟史, 犬伏祥子, 宮脇大輔, 吉田賢史, 小松昇平, 福本巧
    2019, 日本小児血液・がん学会雑誌(Web), 56(2) (2)

  • ヘリカル式強度変調放射線治療におけるMLC latencyモデルの評価手法の検討
    上原和之, 溝延数房, 沖裕也, 王天縁, 西村英輝, 馬屋原博, 原田文, 門脇伸行, 佐々木良平
    2019, 日本放射線腫瘍学会高精度放射線外部照射部会学術大会プログラム・抄録集, 32nd

  • 放射線治療:QOLを考慮した局所治療 小児がんに対する吸収性スペーサーの開発
    佐々木 良平, 岩田 宏満, 亀井 美智, 出水 祐介, 文野 誠久, 中尾 朋平, 淡河 恵津世, 王 天縁, 妹尾 悟史, 犬伏 祥子
    (一社)日本小児血液・がん学会, Oct. 2018, 日本小児血液・がん学会雑誌, 55(4) (4), 169 - 169, Japanese

  • MLCの違いによる照射野外線量の検討
    赤坂 浩亮, 椋本 成俊, 王 天縁, 清水 康之, 大須賀 彩希, 吉田 賢史, 佐々木 良平, 南 利明, 吉田 直碁, 西尾 卓郎, 西谷 隆治, 青山 裕一
    (公社)日本医学放射線学会, Feb. 2017, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 41 - 41, Japanese

  • 眼瞼周囲皮膚癌に対する新規眼球シールド使用時の線量分布の検討
    椋本 成俊, 宮脇 大輔, 赤坂 浩亮, 王 天縁, 清水 康之, 上薗 玄, 吉田 賢史, 江島 泰生, 佐々木 良平, 吉田 直碁, 表田 真弓, 西谷 隆治, 南 利明, 青山 裕一
    (公社)日本医学放射線学会, Feb. 2016, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 44 - 44, Japanese

■ Lectures, oral presentations, etc.
  • 放射線治療:QOLを考慮した局所治療 小児がんに対する吸収性スペーサーの開発
    SASAKI RYOHEI, 岩田 宏満, 亀井 美智, 出水 祐介, 文野 誠久, 中尾 朋平, 淡河 恵津世, OH TENEN, 妹尾 悟史, 犬伏 祥子
    第60回日本小児血液がん学会, Nov. 2018, Japanese, 日本小児血液がん学会, 京都, Domestic conference
    [Invited]
    Nominated symposium

■ Research Themes
  • Development of Helium Ion CT imaging system
    王 天縁, 沖本 智昭, 山下 智弘, 佐々木 良平, 出水 祐介, 赤城 卓, 徳丸 直郎, 松尾 圭朗
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2024 - 31 Mar. 2027

  • Development of Helium Ion CT Image System for Particle Therapy
    王 天縁, 沖本 智昭, 佐々木 良平, 出水 祐介, 赤城 卓, 徳丸 直郎, 松尾 圭朗
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2021 - 31 Mar. 2024
    本申請はクリニカルクエスチョンに基づき、これまでに解決出来なかった粒子線治療計画時における粒子飛程不確かさ問題の解決に向け、治療室の中で取得可能となる粒子線に基づくイオンCT (Ion Computed Tomography; ICT) 画像システムの新規開発である。申請者らが目指しているヘリウム(Helium)という重い粒子のICTは、軽い陽子(Proton)より物質中の散乱が少なく、重い炭素重粒子(Carbon)より物質中の原子核破砕反応の発生率も少ないため、臨床応用に耐えうる高解像度CT画像の取得に使う粒子として、最も適切であると考えられる。 ヘリウムICT撮影系のシステム構築： 申請者らは兵庫県立粒子線医療センターのシンクロトロン加速器により生成される150 MeV/uエネルギーのヘリウム粒子を使う。このシステムは拡大照射法であり、コーンビームの投影データを一気に収集できる。これにより撮影時間を短縮することが出来る。粒子線の照射ポートが水平方向に固定されているため、ローテーションテーブルを用いて、数度ごとに投影データを取得する。本申請では空間分解能の高い投影データを取得するため、シンチレーションとCMOSカメラを組み合わせた暗箱を作成する。シンチレーションには線エネルギー移行量(LET)に対する直線性に優れているジンクセルファイド(ZnS)を使用する。これによって線量を低いところまで正確に測定し、且つ検出器の空間分解能を0.5mm2程度にまで向上させる。

  • Development of Radiosensitizing Fiducial Marker by Nano Particle Delivery
    Wang Tianyuan
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Kobe University, 01 Apr. 2019 - 31 Mar. 2021
    This research is a novel development of an implantable therapeutic marker capable of delivering inorganic nanoparticles. The applicants developed independently using the radiosensitizing effect as a factor for radiotherapy . We found that nanoparticles of titanium oxide generate a large amount of hydroxyl radicals upon X-ray irradiation. In order to extremely improve this sensitization efficiency, we aim to develop a new therapeutic device that utilizes a visible metal marker that is implanted near the tumor, and the nanoparticles released from the marker are directly incorporated into the tumor, producing the greatest anti-tumor effect during the irradiation period.

  • 王 天縁
    学術研究助成基金助成金／若手研究(B), Apr. 2017 - Mar. 2019, Principal investigator
    Competitive research funding

  • 佐々木 良平
    科学研究費一部基金／基盤研究(B), Apr. 2016 - Mar. 2019
    Competitive research funding

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