SEARCH
Search Details
AZUMI MahoUniversity Hospital / Obstetrics and GynecologyAssistant Professor
Research activity information
■ Paper- (一社)日本癌治療学会, Oct. 2025, 日本癌治療学会学術集会抄録集, 63回, O31 - 6, English卵巣がん患者の腟分泌液に含まれる細胞外小胞(EV)内miR-575の低下
- BACKGROUND/AIM: Ovarian cancer is asymptomatic in its early stages, and often diagnosed at advanced stages, leading to a high recurrence rate. In recent years, exosomes have been shown to be useful for early-detection, prognosis prediction, and treatment of cancer. Although many studies of cancer-related exosomes using other bodily fluids have been reported, there are few studies examining vaginal discharge, but none related to ovarian cancer. In this study, we investigated a method for early-detection of ovarian cancer using vaginal discharge, which are physically close to the fallopian tubes, where ovarian cancer originates, and can be easily collected from outside the body. MATERIALS AND METHODS: Vaginal discharge was collected from 30 patients with ovarian cancer and 29 patients with benign gynecological diseases, and exosomal miRNAs were extracted. Samples from each group were submitted to miRNA microarray in order to examine miRNAs with significant differences in expression levels. We further narrowed down the list to four miRNAs based on literature and microarray data and examined the expression levels of miRNAs in the malignant and benign groups by RT-qPCR. RESULTS: MiR-575 expression was significantly decreased in the malignant group compared to the benign group (p=0.00861). qPCR results were analyzed for several patient characteristics and no significant differences were found. CONCLUSION: This is the first study to investigate exosomal miRNAs in vaginal discharge of ovarian cancer. Exosomal miR-575 in vaginal discharge may be used as a biomarker for ovarian cancer.2025, Cancer genomics & proteomics, 22(3) (3), 382 - 396, English, International magazineScientific journal
- Radiotherapy (RT) is used to manage cervical cancer, and pelvic insufficiency fracture (PIF) is known as a late complication of RT. The present study identified risk factors for PIF after radiotherapy for cervical cancer, and investigated its incidence rate. It also considered the usefulness of positron emission tomography/magnetic resonance imaging (PET/MRI) in PIF diagnosis. A total of 149 patients with cervical cancer who received definitive or adjuvant RT with/without concurrent chemotherapy between January 2013 and December 2018 were investigated in the present study and followed up for more than one month after RT at Kobe University Hospital. The median follow-up period was 32 months (range, 1-87 months), and the median age of all patients was 66 years (age range, 34-90 years). Computed tomography (CT), MRI, PET/CT or PET/MRI were used for image examination. Among the 149 patients, 31 (20.8%) developed PIF. The median age of these patients was 69 years (age range, 44-87 years). Univariate analysis using the log-rank test demonstrated that age (≥60 years) was significantly associated with PIF. The median maximum standardized uptake value of PIF sites on PET/CT was 4.32 (range, 3.04-4.81), and that on PET/MRI was 3.97 (range, 1.21-5.96) (P=0.162). Notably, the detection time of PIF by PET/MRI was significantly earlier compared with PET/CT (P<0.05). The incidence of PIF after RT for cervical cancer was 20.8%, and age was significantly associated with risk factors for such fractures. Taken together, these results suggest that PET/MRI, which offers the advantage of decreased radiation exposure to the patient, is useful for diagnosing PIF and can detect it earlier than PET/CT imaging.Nov. 2021, Oncology letters, 22(5) (5), 776 - 776, English, International magazineScientific journal
- BACKGROUND: Serous endometrial intraepithelial carcinoma (SEIC) is now considered to represent an early stage of uterine serous carcinoma (USC). It is an intraepithelial lesion but has been reported to cause extrauterine metastases. We report a case of SEIC with serous ovarian carcinoma and lymph node metastasis. CASE PRESENTATION: A 57-year-old post-menopausal woman (gravida 3, para 2, SA1) was referred to our hospital with lower abdominal pain. An ultrasound and MRI showed that the ovary had swollen to 8 cm in size and had a solid lesion. The uterus was normal. The patient underwent exploratory laparoscopy on the suspicion of torsion of the ovarian tumor. Intraoperative findings showed a right ovarian tumor, but no ovarian tumor torsion was observed. A small amount of bloody ascites was found in the Douglas fossa, and bleeding was observed from the tumor itself. A right salpingo-oophorectomy was then performed. Histopathological results revealed a high-grade serous carcinoma. Forty days after the first surgery, we performed a staging laparotomy: a total abdominal hysterectomy, left salpingo-oophorectomy, systematic pelvic and paraaortic lymphadenectomy, and a partial omentectomy. A complete cytoreduction was achieved. In the pathological examination, the invasion of the serous carcinoma was observed in the left ovarian ligament, and lymph node metastasis was found in the paraaortic lymph nodes. Atypical columnar cells formed irregular papillary lesions which had proliferated in the endometrium, and this was diagnosed as SEIC. The final diagnosis was serous ovarian cancer, FIGO stage IIIA1(ii), pT2bN1M0, with SEIC. CONCLUSION: We report a case of SEIC with synchronous serous carcinoma of the adnexa uteri. Both were serous carcinomas and, thus, it was difficult to identify the primary lesion. The distinction between metastatic cancer and two independent primary tumors is important for an accurate diagnosis and tumor staging. Histological diagnostic criteria remain controversial, and further development of a method for differentiating between both diseases is required.Jun. 2021, Journal of ovarian research, 14(1) (1), 87 - 87, English, International magazineScientific journal
- (公社)日本婦人科腫瘍学会, Apr. 2020, 日本婦人科腫瘍学会雑誌, 38(2) (2), 193 - 199, Japanese
- Primary peritoneal carcinosarcomas which arise from extragenital locations are extremely rare. Carinosarcomas contain both carcinomatous and sarcomatous elements and can be mainly detected in the female genital tract. We herein report a case of primary peritoneal carcinosarcoma diagnosed by laparoscopic surgery and treated with olaparib. A 62-year-old woman referred to our hospital due to abdominal distension. From imaging findings, we suspected advanced primary peritoneal carcinoma, and laparoscopic surgery was thereafter performed. The pathological diagnosis was carcinosarcoma, and the patient received chemotherapy with docetaxel and carboplatin. After three cycles of chemotherapy, the interval debulking surgery was attempted but resulted in suboptimal results. Because the bilateral ovaries were observed with a normal size and normal findings, we considered that the most likely diagnosis was primary peritoneal carcinosarcoma. After the additional chemotherapy and a 6-month observation period, the tumor relapsed. The patient received chemotherapy again, and the peritoneal carcinosarcoma was judged to be a platinum-sensitive tumor. Oral administration of olaparib was thus initiated. Although a dose reduction was needed due to anemia, olaparib was effective, and the patient could continue the drug for another 7 months. This is the first report of primary peritoneal carcinosarcoma treated with olaparib and shows that it could be a treatment option for platinum-sensitive tumors.2020, Case reports in obstetrics and gynecology, 2020, 9106390 - 9106390, English, International magazineScientific journal
- (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 451 - 451, Japanese卵巣癌初回治療におけるdose-dense TC療法とTC+bevacizumab併用療法の比較
- (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 457 - 457, Japanese卵巣癌・腹膜癌の術前化学療法時の診断において、腹腔鏡下生検と体腔液Cell block法の比較検討
- (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 530 - 530, Japanese妊孕性温存手術を施行したI期の卵巣上皮性境界悪性腫瘍の予後に関する検討
- 「産婦人科の進歩」編集室, May 2019, 産婦人科の進歩, 71(2) (2), 230 - 230, Japanese
- 2023, 日本婦人科ロボット手術学会プログラム・抄録集(Web), 11th国産手術支援ロボットhinotoriの臨床導入に向けて
- 2021, 日本エンドメトリオーシス学会学術講演会プログラム・抄録集, 42nd子宮内膜症を合併した子宮奇形に対し,腹腔鏡下手術を施行した2例
- 2021, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 22nd血管内へ浸潤再発したdeep soft tissue leiomyomaの1例
- 2021, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 22nd非交通性副角子宮に対し腹腔鏡下摘出術を施行し,腺筋症の診断に至った一例
- 2021, 日本産科婦人科内視鏡学会学術講演会(Web), 61st経腟回収困難な巨大子宮筋腫に対する下腹部小開腹ハイブリッド手術の有用性
- 2021, 日本産科婦人科内視鏡学会学術講演会(Web), 61stTrousseau症候群を契機に判明した原発不明癌に対して腹腔鏡下腫瘍生検術を施行した一例
- 2021, 日本産科婦人科内視鏡学会学術講演会(Web), 61st定型化された腹腔鏡術式はロボット支援下子宮悪性腫瘍手術でも有用か
- 2021, 日本産科婦人科内視鏡学会学術講演会(Web), 61st75歳以上の高齢者に対する鏡視下手術の検討
- (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 451 - 451, Japanese卵巣癌初回治療におけるdose-dense TC療法とTC+bevacizumab併用療法の比較
- (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 457 - 457, Japanese卵巣癌・腹膜癌の術前化学療法時の診断において、腹腔鏡下生検と体腔液Cell block法の比較検討
- (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 476 - 476, Japanese子宮頸がんに対する放射線治療後不全骨折発症のリスクについての検討
- (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 530 - 530, Japanese妊孕性温存手術を施行したI期の卵巣上皮性境界悪性腫瘍の予後に関する検討
- 「産婦人科の進歩」編集室, May 2019, 産婦人科の進歩, 71(2) (2), 230 - 230, Japanese当院で経験した腹膜原発癌肉腫の2例