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KIMURA Atsushi
Graduate School of Medicine / Department of Medicine
Associate Professor

Researcher basic information

■ Research Areas
  • Life sciences / Psychiatry

Research activity information

■ Paper
  • Takashi Hirata, Akitoyo Hishimoto, Ikuo Otsuka, Satoshi Okazaki, Shuken Boku, Atsushi Kimura, Tadasu Horai, Ichiro Sora
    Background: Life expectancy is 10-20 years lower in patients with schizophrenia than in the general population. In addition, men with schizophrenia have an earlier age at onset, more pronounced deficit symptoms, poorer course, and poorer response to antipsychotic medications than women. Recent studies have indicated that loss of chromosome Y (LOY) in peripheral blood is associated with an increased risk of all-cause mortality. In order to elucidate the pathophysiology of male-specific features, we investigated the association between LOY and schizophrenia. Materials and methods: The present study included 360 Japanese men (146 patients with schizophrenia vs 214 controls). The relative amount of Y chromosome was defined as the ratio of chromosome Y to chromosome X (Y/X ratio) based on the fluorescent signal of co-amplified short sequences from the Y-X homologous amelogenin genes (AMELY and AMELX). Results: There was no significant difference in the frequency of LOY between the schizophrenia and control groups. However, longer duration of illness was associated with LOY after controlling for age and smoking status in the schizophrenia group (P=0.007, OR =1.11 [95% CI =1.03-1.19]). Conclusion: According to our results, schizophrenia may not have a remarkable effect on blood LOY; however, LOY may be associated with disease course in patients with schizophrenia.
    2018, Neuropsychiatric disease and treatment, 14, 2115 - 2122, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Association study of MIF promoter polymorphosms with suicide completers in the Japanese population
    SHINMYOU NAOFUMI, HISHIMOTO AKITOYO, OTSUKA IKUO, 岡崎 賢志, BOKU SHUKEN, MOURI KENTARO, HOURAI TADASU, 江口 典臣, KIMURA ATSUSHI, 山木 愛久, HIRATA TAKASHI, TAKAHASHI MOTONORI, UENO YASUHIRO, SHIRAKAWA OSAMU, SORA ICHIRO
    Sep. 2017, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 39回・47回, Japanese
    Research society

  • Shorter telomere length in suicide completers
    OTSUKA IKUO, HISHIMOTO AKITOYO, 泉 剛, BOKU SHUKEN, KIMURA ATSUSHI, 張 園, MOURI KENTARO, 岡崎 賢志, TAKAHASHI MOTONORI, UENO YASUHIRO, SHIRAKAWA OSAMU, SORA ICHIRO
    Sep. 2017, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 39回・47回, Japanese
    Research society

■ Lectures, oral presentations, etc.
  • ベンゾジアゼピン系薬と修正型電気けいれん療法（ｍECT）が奏功せずメマンチンが有効であった遅発性緊張病の１例
    新谷 敏夫, HISHIMOTO AKITOYO, 谷藤 貴紀, KIMURA ATSUSHI, SHINMYOU NAOFUMI, HOURAI TADASU, OTSUKA IKUO, AOYAMA SHINSUKE, SORA ICHIRO
    第124回 近畿精神神経学会, Feb. 2019, Japanese, 近畿精神神経学会, 和歌山, Domestic conference
    Oral presentation

  • Mosaic loss of chromosome Y in peripheral blood and its risk variants in men with schizophrenia
    平田 尚士, 岡﨑 賢志, OTSUKA IKUO, BOKU SHUKEN, AOYAMA SHINSUKE, 江口 典臣, KIMURA ATSUSHI, HOURAI TADASU, SORA ICHIRO, HISHIMOTO AKITOYO
    WFSBP Asia Pacific Regional Congress of Biological Psychiatry 2018 KOBE, Sep. 2018, English, Kobe, International conference
    Poster presentation

  • Loss of chromosome Y in blood, but not in brain, of suicide completers
    OTSUKA IKUO, 岡﨑 賢志, KIMURA ATSUSHI, HOURAI TADASU, 泉 剛, Motonori Takahashi, Yasuhiro Ueno, 白川 治, SORA ICHIRO, HISHIMOTO AKITOYO
    WFSBP Asia Pacific Regional Congress of Biological Psychiatry 2018 KOBE, Sep. 2018, English, Kobe, International conference
    Poster presentation

  • うつ病の診断で加療中に、著しい嚥下機能障害と非定型的な亜昏迷様症状を呈し診断に苦慮した１例
    塚本 亮, KIMURA ATSUSHI, SHINMYOU NAOFUMI, HOURAI TADASU, OTSUKA IKUO, TAMIYA HIROKO, AOYAMA SHINSUKE, BOKU SHUKEN, HISHIMOTO AKITOYO, SORA ICHIRO
    第123回近畿精神神経学会, Aug. 2018, Japanese, 近畿精神神経学会, 大阪, Domestic conference
    Oral presentation

  • 統合失調症症状とパーキンソン症状を合併した22ｑ11.2欠失症候群に対し修正型電気けいれん療法が奏功した１例
    谷藤 貴紀, HISHIMOTO AKITOYO, KIMURA ATSUSHI, 佐竹 渉, SORA ICHIRO
    第114回日本精神神経学会学術総会, Jun. 2018, Japanese, 日本精神神経学会, 神戸, Domestic conference
    Oral presentation

  • アルコール依存症にアルコール性心筋症が合併し、断酒により心機能が改善した症例
    塚本 亮, Hishimoto Akitoyo, Aoyama Shinsuke, Boku Shuken, Tamiya Hiroko, Otsuka Ikuo, Matsuyama Kenichi, Ichiro Sora
    第122回近畿精神神経学会, Feb. 2018, Japanese, 近畿精神神経学会, 京都, Domestic conference
    Oral presentation

  • SIRT1 遺伝子と自殺
    平田 尚士, Otsuka Ikuo, 岡崎 賢志, 山木 愛久, Boku Shuken, Hishimoto Akitoyo
    第36回躁うつ病の薬理・生物学的研究懇話会, Oct. 2017, Japanese, 東京, Domestic conference
    Oral presentation

  • 日本人自殺既遂者におけるMIF遺伝子プロモーター領域機能的多型の関連解析
    新名 尚史, Hishimoto Akitoyo, Otsuka Ikuo, 岡崎 賢志, Boku Shuken, 毛利 健太朗, 蓬莱 政, 江口 典臣, 木村 敦, 山木 愛久, 平田 尚士, Takahashi Motonori, Ueno Yasuhiro, 白川 治, Ichiro Sora
    第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会, Sep. 2017, Japanese, 日本生物学的精神医学会・日本神経精神薬理学会, 札幌, Domestic conference
    Poster presentation

  • 自殺既遂者におけるテロメア異常短縮
    Otsuka Ikuo, Hishimoto Akitoyo, 泉 剛, Boku Shuken, 木村 敦, 張 園, 毛利 健太朗, 岡崎 賢志, Takahashi Motonori, Ueno Yasuhiro, 白川 治, Ichiro Sora
    第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会, Sep. 2017, Japanese, 日本生物学的精神医学会・日本神経精神薬理学会, 札幌, Domestic conference
    Oral presentation

  • 全身性エリテマトーデス加療中に急性精神病状態を呈し診断に難渋した症例
    塚本 亮, Matsuyama Kenichi, Hishimoto Akitoyo, Aoyama Shinsuke, Boku Shuken, Tamiya Hiroko, Otsuka Ikuo, Ichiro Sora
    第121回近畿精神神経学会, Aug. 2017, Japanese, 近畿精神神経学会, 滋賀, Domestic conference
    Oral presentation

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