Research activity information

• 2007 日本心臓血管外科学会, 第37回日本心臓血管外科学会 最優秀演題, 感染性心内膜炎、大動脈炎症候群によるLV-Ao discontinuityに対する大動脈基部再建術

  Okada Kenji


• 2002 日本心臓財団, 第28回日本心臓財団研究奨励金賞, 移植後冠動脈硬化症進展におけるPPAR-γの意義

  Okada Kenji


• Nov. 1999 72nd Scientific Sessions of American Heart Association, Counand and Comroe Young Investigator Award, Council on Cardiopulmonary and Critical Care

  Okada Kenji

• Effects of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on cardiac surgery: A randomized controlled trial

  Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Kodai Komaki, Takumi Hirabayashi, Kumiko Wakida, Saori Saitoh, Takeshi Inoue, Tomoya Yamashita, Yoshitada Sakai, Michiko Takahashi, Kenji Okada, Ken-ichi Hirata

  Elsevier BV, Dec. 2024, Clinical Nutrition

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Intense impact of IL-1β expressing inflammatory macrophages in acute aortic dissection.

  Taishi Inoue, Takuo Emoto, Katsuhiro Yamanaka, Shunya Chomei, Shunsuke Miyahara, Hiroaki Takahashi, Ryohei Shinohara, Takeshi Kondo, Masayuki Taniguchi, Tomoyuki Furuyashiki, Tomoya Yamashita, Ken-Ichi Hirata, Kenji Okada

  There is no treatment for acute aortic dissection (AAD) targeting inflammatory cells. We aimed to identify the new therapeutic targets associated with inflammatory cells. We characterized the specific distribution of myeloid cells of both human type A AAD samples and a murine AAD model generated using angiotensin II (ANGII) and β-aminopropionitrile (BAPN) by single-cell RNA sequencing (scRNA-seq). We also examined the effect of an anti-interleukin-1β (IL-1β) antibody in the murine AAD model. IL1B+ inflammatory macrophages and classical monocytes were increased in human AAD samples. Trajectory analysis demonstrated that IL1B+ inflammatory macrophages differentiated from S100A8/9/12+ classical monocytes uniquely observed in the aorta of AAD. We found increased infiltration of neutrophils and monocytes with the expression of inflammatory cytokines in the aorta and accumulation of inflammatory macrophages before the onset of macroscopic AAD in the murine AAD model. In blocking experiments using an anti-IL-1β antibody, it improved survival of murine AAD model by preventing elastin degradation. We observed the accumulation of inflammatory macrophages expressing IL-1β in both human AAD samples and in a murine AAD model. Anti-IL-1β antibody could improve the mortality rate in mice, suggesting that it may be a treatment option for AAD.

  Jun. 2024, Scientific reports, 14(1) (1), 14893 - 14893, English, International magazine

  Scientific journal


• Impact of maximum phonation time on postoperative dysphagia and prognosis after cardiac surgery

  Masato Ogawa, Seimi Satomi-Kobayashi, Mari Hamaguchi, Kodai Komaki, Hifumi Kusu, Kazuhiro P. Izawa, Shunsuke Miyahara, Yoshitada Sakai, Ken-ichi Hirata, Kenji Okada

  Elsevier BV, Feb. 2024, JTCVS Open

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 血管疾患のゲノム、トランスクリプトーム解析 シングルセル解析を用いた、免疫をターゲットとした大動脈解離治療法開発

  江本 拓央, 井上 大志, 山中 勝弘, 山下 智也, 岡田 健次, 平田 健一

  (一社)日本脈管学会, Oct. 2023, 脈管学, 63(Suppl.) (Suppl.), S124 - S124, Japanese


• 腹部大動脈ステントグラフト留置術後早期に腹部大動脈十二指腸瘻を来した一例

  井上 大志, 大村 篤史, 中井 秀和, 阪口 和憲, 岡田 翼, 白木 宏長, 岩橋 大輔, 長谷川 翔太, 長命 俊也, 濱口 真里, 河野 敦則, 辻本 貴紀, 村上 優, 幸田 陽次郎, 山中 勝弘, 井上 武, 岡田 健次, 長谷川 寛, 中村 哲, 掛地 吉弘

  兵庫県外科医会, Mar. 2023, 兵庫県外科医会会誌, 57, 42 - 45, Japanese


• 【大動脈ステントグラフトの温故知新】EVARのエビデンスと長期成績向上に関する最近の話題

  元津 倫幸, 山口 雅人, 松代 啓吾, 佐々木 康二, 上嶋 英介, 岡田 卓也, 杉本 幸司, 村上 卓道, 中井 秀和, 山中 勝弘, 岡田 健次, 川崎 竜太

  (一社)日本インターベンショナルラジオロジー学会, Feb. 2023, 日本インターベンショナルラジオロジー学会雑誌, 37(1) (1), 2 - 12, Japanese


• Type 2 endoleakの抑制を目的とした腹部大動脈瘤に対するEndurantを用いたEVAR前の分枝塞栓術に関する多施設共同前向き臨床研究

  元津 倫幸, 山口 雅人, 佐々木 康二, 幸田 陽次郎, 宮原 俊介, 山中 勝弘, 高橋 宏明, 野村 佳克, 林 太郎, 後竹 康子, 岡田 健次

  (NPO)日本血管外科学会, 2023, 日本血管外科学会雑誌, 32(Suppl.) (Suppl.), O14 - 1, Japanese


• A new clinical classification and reconstructive strategy for post-sternotomy surgical site infection.

  Daiki Kitano, Hiroaki Takahashi, Tadashi Nomura, Kenji Okada, Hiroto Terashi, Shunsuke Sakakibara

  INTRODUCTION: Post-sternotomy surgical site infection (SSI) is a serious complication of cardiovascular surgery. Here, we proposed a new clinical classification and reconstructive strategy for this condition. METHODS: A retrospective study based on medical records was performed on 100 consecutive cases requiring wound management by plastic surgeons for post-sternotomy SSI at Kobe University Hospital between January 2009 and December 2021. We classified 100 cases into four categories according to the anatomical invasiveness of the infection (type 1, superficial SSI; type 2, sternal osteomyelitis; type 3, mediastinitis; and type 4, aortic graft infection). The standard treatment plan comprised initial debridement, negative pressure wound therapy with continuous irrigation, and reconstructive surgery. Reconstructive methods and their outcomes (in-hospital mortality rate, follow-up period, and infection recurrence rate) were investigated for each SSI category. RESULTS: There were nine SSI cases in type 1, 28 in type 2, 25 in type 3, and 38 in type 4. The pectoralis major (PM) muscle advancement flap was mainly selected in types 1 and 2 (100 and 70.4%, respectively), while the omental flap or latissimus dorsi (LD) myocutaneous flaps were mainly selected in types 3 and 4 (77.3 and 81.8%, respectively) for reconstructive surgery. The in-hospital mortality rates for types 1, 2, 3, 4 were 44.4, 3.6, 12.0, and 15.8%, respectively. The mean follow-up periods for types 1, 2, 3, 4 were 542.8, 1514.5, 1154.5, and 831.1 days, respectively. Infection recurrence rates for types 1, 2, 3, 4 were 0, 11.5, 13.3, and 19.2%, respectively. All of these recurrent cases, except for 4 cases of type 4 that required surgical intervention, were treated with conservative wound management. CONCLUSION: A volume-rich flap (omental or LD flap) was required to fill the dead space after debridement in mediastinitis (type 3) or aortic graft infection (type 4), whereas superficial SSI (type 1) or sternal osteomyelitis (type 2) received a less-invasive flap (PM muscle advancement flap). Our new classification method was based on the anatomical invasiveness of the infection, providing both a simple and easy diagnosis and definitive treatment strategy.

  Dec. 2022, Regenerative therapy, 21, 519 - 526, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Gut Microbiota Influence the Development of Abdominal Aortic Aneurysm by Suppressing Macrophage Accumulation in Mice.

  Ryohei Shinohara, Hitomi Nakashima, Takuo Emoto, Tomoya Yamashita, Yoshihiro Saito, Naofumi Yoshida, Taishi Inoue, Katsuhiro Yamanaka, Kenji Okada, Ken-Ichi Hirata

  BACKGROUND: Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease characterized by dilated abdominal aorta. Immune cells have been shown to contribute to the development of AAA, and that the gut microbiota is associated with numerous diseases, including cardiovascular diseases, by regulating immune systems or metabolic pathways of the host. However, the interaction between the gut microbiota and AAA remains unknown. METHODS: Apolipoprotein E-deficient male mice were fed a high-cholesterol diet and divided into three groups: the control group was maintained under normal water (control group), the oral AVNM group was maintained under drinking water supplemented with ampicillin, vancomycin, neomycin, and metronidazole, and the i.p. AVNM group was injected AVNM intraperitoneally. After 1 week of pretreatment with antibiotics, these mice were administrated Ang II via subcutaneous osmotic pumps for 4 weeks and euthanized to evaluate AAA formation. RESULTS: Depletion of gut microbiota by oral AVNM ameliorated the incidence of AAAs (control group: 58.9% versus oral AVNM group: 28.6% versus i.p. AVNM group: 75.0%, P = 0.0005) and prevented death due to ruptured aneurysms (control group: 11% versus oral AVNM group: 0% versus i.p. AVNM group: 15%). Oral AVNM suppressed monocyte storage in the spleen, but not in other organs. Despite possessing a higher level of cholesterol, recruitment of monocytes into the suprarenal aorta was suppressed in the oral AVNM group. In AVNM drinking mice, NOD1 ligand, a kind of PRR ligands, increased the development of AAAs and accumulation of macrophages in the aortae. CONCLUSIONS: The gut microbiota plays a critical role in AAA formation. Therefore, regulation of the microbiota or the immune system can be a therapeutic approach for AAA.

  Dec. 2022, Hypertension (Dallas, Tex. : 1979), 79(12) (12), 2821 - 2829, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Virtual Reality Computed Tomography Evaluation - Anatomy and Clinical Implications for Valve-Sparing Aortic Root Replacement.

  Takanori Tsujimoto, Takeo Tedoriya, Yasushi Yamauchi, Yutaka Okita, Kenji Okada

  BACKGROUND: Three-dimensional aortic root evaluation using virtual reality (VR) techniques for valve-sparing aortic root replacement (VSARR) preparation has not yet been implemented, so we demonstrated VR computed tomography (VR-CT) and assessed its utility for VSARR.Methods and Results: We enrolled 72 patients who underwent multidetector CT before elective VSARR for annuloaortic ectasia with tricuspid aortic valve. The geometries of their aortic roots were measured with a VR-CT workstation. The mean values of geometric height (GH), free margin length (FML), and commissural height (CH) were 17.2±2.4 mm, 36.0±5.2 mm, and 24.0±4.3 mm, respectively. The right coronary/noncoronary CH was significantly greater than the left coronary/right coronary and left coronary/noncoronary CH. The left coronary cusp had the shortest FML, intercommissural distances (ICD), and smallest central angle. Although the right coronary cusp had the largest values for FML, ICD, and central angle, the right coronary cusp had the lowest GH and EH. The VR-CT measurements strongly correlated with intraoperative alternatives, especially with mean GH (R2=0.75) and left coronary/noncoronary CH (R2=0.79). Furthermore, mean GH was observed to be significantly different among the selected graft size groups; therefore, the preoperative mean GH could play a significant role in graft sizing. CONCLUSIONS: VR-CT evaluation allows a thorough understanding of aortic root anatomy, which could facilitate VSAAR.

  Oct. 2022, Circulation journal : official journal of the Japanese Circulation Society, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Postoperative dysphagia as a predictor of functional decline and prognosis after undergoing cardiovascular surgery

  Masato Ogawa, Seimi Satomi-Kobayashi, Mari Hamaguchi, Kodai Komaki, Kazuhiro P Izawa, Shunsuke Miyahara, Takeshi Inoue, Yoshitada Sakai, Ken-ichi Hirata, Kenji Okada

  Abstract Aims Post-extubation dysphagia (PED), an often overlooked problem, is a common and serious complication associated with mortality and major morbidity after cardiovascular surgery. Dysphagia is considered an age-related disease, and evaluating its long-term effects is a pressing issue with rapidly progressing ageing worldwide. Therefore, we examined the effect of PED on functional status and long-term cardiovascular events in patients undergoing cardiovascular surgery. Methods and results This single-centre, retrospective cohort study included 712 patients who underwent elective cardiovascular surgery and met the inclusion criteria. Patients were divided into PED and non-PED groups based on their post-operative swallowing status. The swallowing status was assessed using the Food Intake Level Scale. Functional status was evaluated as hospital-associated disability (HAD), defined as a decrease in activities of daily living after hospital discharge compared with preoperative values. The patients were subsequently followed up to detect major adverse cardiac and cerebrovascular events (MACCEs). Post-extubation dysphagia was present in 23% of the 712 patients and was independently associated with HAD (adjusted odds ratio, 2.70). Over a 3.5-year median follow-up period, MACCE occurred in 14.1% of patients. Multivariate Cox proportional hazard analysis revealed HAD to be independently associated with an increased risk of MACCE (adjusted hazard ratio, 1.85), although PED was not significantly associated with MACCE. Conclusion Post-extubation dysphagia was an independent HAD predictor, with the odds of HAD occurrence being increased by 2.7-fold due to PED. Hospital-associated disability accompanied by PED is a powerful predictor of poor prognosis. Perioperative evaluation and management of the swallowing status, and appropriate therapeutic interventions, are warranted.

  Oxford University Press (OUP), Sep. 2022, European Journal of Cardiovascular Nursing, 22(6) (6), 602 - 609

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Spinal cord ischemia after elective endovascular abdominal aortic aneurysm repair in a patient with multiple occlusions of the intercostal and internal iliac arteries.

  Yojiro Koda, Katsuhiro Yamanaka, Atsushi Omura, Tomoyuki Gentsu, Masato Yamaguchi, Kenji Okada

  Spinal cord ischemia (SCI) after endovascular abdominal aortic aneurysm repair is a rare but devastating complication. Occlusion of the artery of Adamkiewicz or feeders to the collateral network for spinal cord circulation (such as the subclavian, intercostal, lumbar, and internal iliac arteries) is associated with the onset of SCI. We present a case of monoplegia owing to SCI after elective endovascular abdominal aortic aneurysm repair with coil embolization of the left internal iliac artery in an elderly patient with a history of arteriosclerosis obliterans and aortic dissection, preoperatively occluding multiple intercostal arteries and the right internal iliac artery.

  Sep. 2022, Journal of vascular surgery cases and innovative techniques, 8(3) (3), 447 - 449, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• RC time (resistance × compliance) is related to residual symptom after pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension.

  Kenichi Yanaka, Kazuhiko Nakayama, Yu Taniguchi, Hiroyuki Onishi, Yoichiro Matsuoka, Hidekazu Nakai, Kenji Okada, Toshiro Shinke, Noriaki Emoto, Ken-Ichi Hirata

  BACKGROUND: Right ventricular (RV) afterload is widely assessed by pulmonary vascular resistance (PVR). However, RV afterload is underestimated because PVR does not account for the pulsatile load. The pulsatile load is often evaluated by pulmonary arterial compliance (PAC). The RC (resistance-compliance) time, which is calculated from the product of PVR and PAC, is considered to remain constant under medical therapy. However, little is known on how RC time is affected by invasive therapy in chronic thromboembolic pulmonary hypertension (CTEPH). This study aimed to evaluate change of RC time in patients underwent pulmonary endarterectomy (PEA). Furthermore, we investigated the clinical relevance of RC time. METHODS: We reviewed consecutive 50 patients except for death case underwent PEA. Baseline clinical parameters including RC time before performing PEA and follow-up were evaluated. Patients was classified as decrease or non-decrease according to change of RC time. Furthermore, we classified patients into a NYHA I group who had no symptom after treatment and a residual symptom group in order to investigate the relationship of RC time to residual symptoms. RESULTS: RC time was significantly decreased after PEA (0.54 ± 0.16 to 0.45 ± 0.12 sec, p < 0.001). Residual symptom after PEA of Decrease group were significantly better than that of Non-decrease group in RC time (12 patients, 40% vs. 11 patients, 78.6%, p < 0.02). Furthermore, multivariate analysis revealed that only RC time after PEA was independently associated with residual symptom (OR 1.026, 95% CI 1.005-1.048; p = 0.017). CONCLUSIONS: RC time was decreased after PEA, and might be a possible indicator for predicting PEA success.

  Jun. 2022, International journal of cardiology. Heart & vasculature, 40, 101031 - 101031, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 腹部大動脈ステントグラフト留置術後早期に腹部大動脈十二指腸瘻を来した一例

  井上 大志, 大村 篤史, 中井 秀和, 長命 俊也, 濱口 真里, 河野 敦則, 辻本 貴紀, 村上 優, 幸田 陽次郎, 山中 勝弘, 井上 武, 岡田 健次, 長谷川 寛, 掛地 吉弘

  兵庫県外科医会, Mar. 2022, 兵庫県外科医会会誌, 56, 38 - 38, Japanese


• Impact of Frailty on Postoperative Dysphagia in Patients Undergoing Elective Cardiovascular Surgery.

  Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Kodai Komaki, Kazuhiro P Izawa, Mari Hamaguchi, Takeshi Inoue, Yoshitada Sakai, Ken-Ichi Hirata, Kenji Okada

  BACKGROUND: Postextubation dysphagia (PED) is a serious postoperative complication following cardiovascular surgery that can lead to a worse prognosis. On the other hand, frailty is a prognostic factor in patients who undergo cardiac surgery. OBJECTIVES: This study investigated the effect of frailty status on PED and impact of PED on postoperative complications. METHODS: This single-center retrospective cohort study included 644 consecutive patients who underwent elective cardiovascular surgery between May 1, 2014, and December 31, 2020; they were assigned to the PED or non-PED group based on postoperative swallowing status, and postoperative complications were investigated. Frailty status and physical functions, including walking speed, grip strength, Short Physical Performance Battery, and 6-minute walking distance, were preoperatively assessed; the frailty-status cutoff for predicting PED was determined from the receiver-operating characteristic curve. RESULTS: In this study cohort (mean age 67.7 years), the overall PED prevalence was 14.8%; preoperative frailty had a significantly higher prevalence in the PED group (50.0%) than in the non-PED group (20.3%; P < 0.001). PED correlated with a higher incidence of postoperative pneumonia and prolonged intensive care unit or hospital stay (P < 0.05 for all). After adjustment for confounders, multiple regression analysis revealed that preoperative frailty was independently associated with PED (P < 0.001). CONCLUSIONS: PED occurred commonly after cardiovascular surgery and increased the risk of postoperative complications. Preoperative frailty was independently associated with PED. The 6-minute walking distance was the most powerful predictor of PED. Evaluation of preoperative frailty status is important for risk stratification and prevention of postoperative morbidity in patients undergoing surgery.

  Feb. 2022, JACC. Asia, 2(1) (1), 104 - 113, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• ショックを伴う破裂性胸部大動脈瘤に対して、クラウド型モバイルネットワークを活用し、迅速な治療を行い救命し得た1例

  辻本 貴紀, 山中 勝弘, 長命 俊也, 山口 雅人, 杉本 幸司, 岡田 健次

  (NPO)日本血管外科学会, 2022, 日本血管外科学会雑誌, 31(2) (2), 97 - 101, Japanese


• 腹部大動脈瘤に対するEVARの長期成績と今後の改善点 EVARの長期成績を改善するための予防的大動脈分枝動脈塞栓術の有効性・安全性の検討(多施設共同前向き介入研究)

  山口 雅人, 山中 勝弘, 中井 秀和, 岡田 健次, 林 太郎, 野村 佳克, 杉本 幸司, 福田 哲也, 森 岳樹

  (NPO)日本血管外科学会, 2022, 日本血管外科学会雑誌, 31(Suppl.) (Suppl.), SY10 - 2, Japanese


• Gore Excluder Iliac Branch Endprothesis(IBE)52例の中期成績の検討

  後竹 康子, 高橋 宏明, 松尾 二郎, 杉本 貴樹, 林 太郎, 山口 雅人, 杉本 幸司, 岡田 健次

  (NPO)日本血管外科学会, 2022, 日本血管外科学会雑誌, 31(Suppl.) (Suppl.), PR16 - 2, Japanese


• 急性A型大動脈解離の治療戦略 急性A型大動脈解離に対するaggressive arch repair and direct carotid perfusion strategy

  大村 篤史, 村上 優, 長命 俊也, 岩橋 大輔, 阪口 和憲, 河野 敦則, 岡田 翼, 白木 宏長, 長谷川 翔太, 濱口 真理, 井上 大志, 辻本 貴紀, 幸田 陽次郎, 中井 秀和, 山中 勝弘, 井上 武, 岡田 健次

  (一社)日本脈管学会, Oct. 2021, 脈管学, 61(Suppl.) (Suppl.), S132 - S133, Japanese


• AAA未来へ向けたミッション 腹部大動脈瘤の治療成績 医療費にかかる問題は無視できるか?

  山中 勝弘, 坂口 和憲, 岡田 翼, 白木 宏長, 長谷川 翔太, 濱口 真里, 長命 俊哉, 井上 大志, 河野 敦規, 辻本 貴紀, 村上 優, 幸田 陽次郎, 中井 秀和, 大村 篤史, 井上 武, 岡田 健次

  (一社)日本脈管学会, Oct. 2021, 脈管学, 61(Suppl.) (Suppl.), S140 - S140, Japanese


• 大動脈手術におけるオープンステントグラフトの有用性と今後の課題 急性A型大動脈解離に使用するFrozen elephant trunkのステントサイズ6cmと9cm以上の比較成績

  河野 敦則, 井上 大志, 辻本 貴紀, 村上 優, 幸田 陽次郎, 中井 秀和, 山中 勝弘, 大村 篤史, 井上 武, 岡田 健次

  (一社)日本人工臓器学会, Oct. 2021, 人工臓器, 50(2) (2), S - 25, Japanese


• Prognostic Impact of Myocardial Extracellular Volume Fraction Assessment Using Dual-Energy Computed Tomography in Patients Treated With Aortic Valve Replacement for Severe Aortic Stenosis.

  Masataka Suzuki, Takayoshi Toba, Yu Izawa, Hiroshi Fujita, Keisuke Miwa, Yu Takahashi, Hiroyuki Toh, Hiroyuki Kawamori, Hiromasa Otake, Hidekazu Tanaka, Sei Fujiwara, Yoshiaki Watanabe, Atsushi K Kono, Kenji Okada, Ken-Ichi Hirata

  Background Myocardial extracellular volume fraction (ECV), measured by cardiac magnetic resonance imaging, is a useful prognostic marker for patients who have undergone aortic valve replacement (AVR) for aortic stenosis. However, the prognostic significance of ECV measurements based on computed tomography (CT) is unclear. This study evaluated the association between ECV measured with dual-energy CT and clinical outcomes in patients with aortic stenosis who underwent transcatheter or surgical AVR. Methods and Results We retrospectively enrolled 95 consecutive patients (age, 84.0±5.0 years; 75% women) with severe aortic stenosis who underwent preprocedural CT for transcatheter AVR planning. ECV was measured using iodine density images obtained by delayed enhancement dual-energy CT. The primary end point was a composite outcome of all-cause death and hospitalization for heart failure after AVR. The mean ECV measured with CT was 28.1±3.8%. During a median follow-up of 2.6 years, 22 composite outcomes were observed, including 15 all-cause deaths and 11 hospitalizations for heart failure. In Kaplan-Meier analysis, the high ECV group (≥27.8% [median value]) had significantly higher rates of composite outcomes than the low ECV group (<27.8%) (log-rank test, P=0.012). ECV was the only independent predictor of adverse outcomes on multivariable Cox regression analysis (hazards ratio, 1.25; 95% CI, 1.10‒1.41; P<0.001). Conclusions Myocardial ECV measured with dual-energy CT in patients who underwent aortic valve intervention was an independent predictor of adverse outcomes after AVR.

  Sep. 2021, Journal of the American Heart Association, 10(18) (18), e020655, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 【弓部大動脈瘤-いかに合併症をなくすか】弓部大動脈全置換術の標準化とその成績 術者の経験値は手術成績に影響を与えるか?

  大村 篤史, 井上 大志, 濱口 真理, 村上 優, 長命 俊也, 河野 敦則, 松尾 二郎, 辻本 貴紀, 幸田 陽次郎, 山中 勝弘, 井上 武, 岡田 健次

  (株)南江堂, Apr. 2021, 胸部外科, 74(4) (4), 297 - 303, Japanese


• 慢性B型解離性大動脈瘤に対する治療-オープンからステントグラフトまで- 慢性B型大動脈解離、広範囲大動脈瘤に対するopen surgery

  大村 篤史, 中井 秀和, 長命 俊也, 井上 大志, 濱口 真理, 河野 敦則, 松尾 二郎, 辻本 貴紀, 幸田 陽次郎, 村上 優, 山中 勝弘, 井上 武, 岡田 健次

  (一社)日本外科学会, Apr. 2021, 日本外科学会定期学術集会抄録集, 121回, DB - 1, Japanese


• Impact of Oral Health Status on Postoperative Complications and Functional Recovery After Cardiovascular Surgery

  Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Yasunori Tsuboi, Kodai Komaki, Nagisa Nanba, Kazuhiro P. Izawa, Takeshi Inoue, Yoshitada Sakai, Masaya Akashi, Ken ichi Hirata, Kenji Okada

  Mar. 2021, CJC Open, 3(3) (3), 276 - 284

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The role of balloon pulmonary angioplasty and pulmonary endarterectomy: Is chronic thromboembolic pulmonary hypertension still a life-threatening disease?

  Yu Taniguchi, Yoichiro Matsuoka, Hiroyuki Onishi, Kenichi Yanaka, Noriaki Emoto, Hidekazu Nakai, Kenji Okada, Kenichi Hirata

  BACKGROUND: The management of non-operable chronic thromboembolic pulmonary hypertension (CTEPH) has evolved with the availability of balloon pulmonary angioplasty (BPA) and pulmonary vasodilators. We launched the BPA program in 2011. The aim was to analyze the survival and treatment efficacy of our CTEPH treatment program in the modern management era. METHODS AND RESULTS: We retrospectively reviewed data from 143 consecutive CTEPH patients diagnosed from January 2011 (i.e. after the availability of BPA) to December 2019. Of forty-one patients who underwent pulmonary endarterectomy (PEA), 25 underwent additional BPA (Combination group) and the others were treated with only PEA (PEA group). Ninety patients underwent BPA (BPA group). The remaining 12 patients did not undergo any interventional treatments. The 1- and 5-year survival rates of operated patients (n = 41) were 97.4% and 90.0%, compared to 96.9% and 86.9% in not-operated patients (n = 102), respectively (p = 0.579). There was no mortality in the Combination group. Mean pulmonary artery pressure after treatments in the PEA only, Combination, and BPA only groups was 20.5 ± 6.7, 17.9 ± 4.9, and 20.7 ± 4.6 mmHg, respectively (p = 0.067, one-way ANOVA). Percent decrease of pulmonary vascular resistance in each treatment groups was -73.7 ± 11.3%, -74.3 ± 11.8%, and - 54.9 ± 22.5%, respectively (p < 0.01, one-way ANOVA). CONCLUSION: There was no significant difference in long-term survival between operated and not-operated CTEPH. Moreover, the Combination approach might have the potential to introduce notable improvements in the prognosis of CTEPH. BPA and PEA appear to be mutually complementary therapies in the modern management era.

  Mar. 2021, International journal of cardiology, 326, 170 - 177, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Preoperative frailty affects postoperative complications, exercise capacity, and home discharge rates after surgical and transcatheter aortic valve replacement.

  Kodai Komaki, Naofumi Yoshida, Seimi Satomi-Kobayashi, Yasunori Tsuboi, Masato Ogawa, Kumiko Wakida, Takayoshi Toba, Hiroyuki Kawamori, Hiromasa Otake, Atsushi Omura, Katsuhiro Yamanaka, Takeshi Inoue, Tomoya Yamashita, Yoshitada Sakai, Kazuhiro P Izawa, Kenji Okada, Ken-Ichi Hirata

  Assessment of frailty is important for risk stratification among the elderly with severe aortic stenosis (AS) when considering interventions such as surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). However, evidence of the impact of preoperative frailty on short-term postoperative outcomes or functional recovery is limited. This retrospective study included 234 consecutive patients with severe AS who underwent SAVR or TAVR at Kobe University Hospital between Dec 2013 and Dec 2019. Primary outcomes were postoperative complications, postoperative 6-min walking distance (6MWD), and home discharge rates. The mean age was 82 ± 6.6 years. There were 169 (SAVR: 80, TAVR: 89) and 65 (SAVR: 20, TAVR: 45) patients in the non-frail and frail groups, respectively (p = 0.02). The postoperative complication rates in the frail group were significantly higher than those in the non-frail group [30.8% (SAVR: 35.0%, TAVR: 28.9%) vs. 10.7% (SAVR: 15.0%, TAVR: 6.7%), p < 0.001]. The home discharge rate in the non-frail group was significantly higher than that in the frail group [85.2% (SAVR: 81.2%, TAVR: 88.8%) vs. 49.2% (SAVR: 55.0%, TAVR: 46.7%), p < 0.001]. The postoperative 6MWD in the non-frail group was significantly longer than that in the frail group [299.3 ± 87.8 m (SAVR: 321.9 ± 90.8 m, TAVR: 281.1 ± 81.3 m) vs. 141.9 ± 92.4 m (SAVR: 167.8 ± 92.5 m, TAVR: 131.6 ± 91.3 m), p < 0.001]. The TAVR group did not show a decrease in the 6MWD after intervention, regardless of frailty. We report for the first time that preoperative frailty was strongly associated with postoperative complications, 6MWD, and home discharge rates following both SAVR and TAVR. Preoperative frailty assessment may provide useful indications for planning better individualized therapeutic interventions and supporting comprehensive intensive care before and after interventions.

  Feb. 2021, Heart and vessels, 36(8) (8), 1234 - 1245, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A rare manifestation of primary cardiac intimal sarcoma: mimicking non-bacterial thrombotic endocarditis with severe mitral regurgitation.

  Saki Todo, Takayoshi Toba, Kenji Okada, Ken-Ichi Hirata

  Feb. 2021, European heart journal cardiovascular Imaging, English, International magazine

  Scientific journal


• 膵十二指腸動脈瘤に対してハイブリッド治療を行った2症例

  辻本 貴紀, 大村 篤史, 岡田 卓也, 山口 雅人, 杉本 幸司, 岡田 健次

  (NPO)日本血管外科学会, Feb. 2021, 日本血管外科学会雑誌, 30(1) (1), 7 - 12, Japanese


• The fate of aortic root and aortic regurgitation after supracoronary ascending aortic replacement for acute type A aortic dissection.

  Yuki Ikeno, Koki Yokawa, Katsuhiro Yamanaka, Takeshi Inoue, Hiroshi Tanaka, Kenji Okada, Yutaka Okita

  BACKGROUND: The aim of this study was to evaluate the fate of the preserved aortic root after supracoronary aortic replacement for acute type A aortic dissection. METHODS: Between October 1999 and March 2018, 339 patients underwent supracoronary aortic replacement for acute type A aortic dissection at our institution. Late outcomes were evaluated, including overall survival, aortic-related death, and aortic root-related reoperation. The median follow-up was 3.7 years (1.4-8.4 years). RESULTS: Operative mortality was 46 patients (13.6%). The cumulative incidences at 5 years for aortic root-related reoperation, aortic-related death, and non-aortic related death were 2.5%, 14.5% and 12.4%, respectively. Multivariable Cox hazard regression analysis demonstrated greater sinus of Valsalva diameter and number of commissural detachments to be significant risk factors for a composite outcome consisting of aortic-related death or aortic root-related reoperation. Mixed-effects regression demonstrated that sinus of Valsalva diameter significantly increased with time (P < .001), and aortic regurgitation significantly worsened (P < .001). CONCLUSIONS: Sinus of Valsalva diameter and commissural detachment were independent predictors of unfavorable outcomes after supracoronary aortic replacement. Close follow-up is particularly necessary for these patients, and aortic root replacement at the time of initial operation may lead to more favorable late outcomes.

  Feb. 2021, The Journal of thoracic and cardiovascular surgery, 161(2) (2), 483 - 493, English, International magazine

  Scientific journal


• Reimplantation for annular stabilization in bicuspid aortic valve repair.

  Hiroshi Tanaka, Kenji Okada, Yutaka Okita

  OBJECTIVES: To review the outcomes of bicuspid aortic valve repair with the reimplantation technique. PATIENTS AND METHODS: From 2006 to 2018, 46 patients with bicuspid aortic valve underwent the reimplantation procedure for aortic valve repair. Those patients were included in this study. The mean age was 45 ± 15 years and 44 were male. Preoperative echocardiography showed a mean ventriculoaortic junction diameter of 28 ± 3 mm. The mean diameter at the sinus of Valsalva was 41 ± 9 mm. The minimum cusp height was 19 ± 3 mm. Regarding cusp repair technique, central plication was used in 45 patients, free margin reinforcement in 10 patients, and patch repair in 4 patients. Follow-up was performed by annual echocardiography. RESULTS: There were no hospital deaths. All patients were found with either no/trivial or mild AR on postoperative transesophageal echocardiography. The postoperative ventriculoaortic junction diameter was 23 ± 2 mm and 83 ± 17% preoperatively. Freedom from moderate AR was 85 ± 6% at 5 years, and freedom from reoperation was 93 ± 4% at 5 years. CONCLUSIONS: Reimplantation for bicuspid aortic valve repair showed acceptable mid-term outcomes.

  Feb. 2021, General thoracic and cardiovascular surgery, 69(2) (2), 260 - 266, English, Domestic magazine

  Scientific journal


• Reply: We still have more to do in our life.

  Yutaka Okita, Yuki Ikeno, Kenji Okada

  Jan. 2021, The Journal of thoracic and cardiovascular surgery, English, International magazine


• Normative Aortic Valvar Measurements in Adults Using Cardiac Computed Tomography - A Potential Guide to Further Sophisticate Aortic Valve-Sparing Surgery.

  Yu Izawa, Shumpei Mori, Justin T Tretter, James A Quintessenza, Hiroyuki Toh, Takayoshi Toba, Yoshiaki Watanabe, Atsushi K Kono, Kenji Okada, Ken-Ichi Hirata

  BACKGROUND: A thorough understanding of the anatomy of the aortic valve is necessary for aortic valve-sparing surgery. Normal valvar dimensions and their relationships in the living heart, however, have yet to be fully investigated in a 3-dimensional fashion.Methods and Results:In total, 123 consecutive patients (66±12 years, Men 63%) who underwent coronary computed tomographic angiography were enrolled. Mid-diastolic morphology of the aortic roots, including height of the interleaflet triangles, geometric height, free margin length of each leaflet, effective height, and coaptation length were measured using multiplanar reconstruction images. Average height of the interleaflet triangle, geometric height, free margin length, effective height, and the coaptation length were 17.3±1.8, 14.7±1.3, 32.6±3.6, 8.6±1.4, and 3.2±0.8 mm, respectively. The right coronary aortic leaflet displayed the longest free margin length and shortest geometric height. Geometric height, free margin length, and effective height showed positive correlations with aortic root dimensions. Coaptation length, however, remained constant regardless of aortic root dimensions. CONCLUSIONS: Diversities, as well as characteristic relationships among each value involving the aortic root, were identified using living-heart datasets. The aortic leaflets demonstrated compensatory elongation along with aortic root dilatation to maintain constant coaptation length. These measurements will serve as the standard value for revealing the underlying mechanism of aortic regurgitation to plan optimal aortic valve-sparing surgery.

  Jan. 2021, Circulation journal : official journal of the Japanese Circulation Society, 85(7) (7), 1059 - 1067, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Malperfusionを伴う急性A型大動脈解離に対する治療戦略 頸動脈解離が急性A型大動脈解離の脳神経合併症に与える影響当院の手術戦略の変遷

  井上 大志, 大村 篤史, 山中 勝弘, 濱口 真里, 長命 俊也, 河野 敦則, 辻本 貴紀, 村上 優, 幸田 陽次郎, 中井 秀和, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2021, 日本血管外科学会雑誌, 30(Suppl.) (Suppl.), SY3 - 8, Japanese


• ステントによる内膜損傷をめぐる問題(RTADとd-SINE) 急性A型大動脈解離におけるFrozen elephant trunkのサイズ選択と遠隔成績 術前詳細なplanningは必要か?

  河野 敦則, 大村 篤志, 濱口 真里, 長命 俊也, 井上 大志, 辻本 貴紀, 幸田 陽次郎, 村上 優, 中井 秀和, 山中 勝弘, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2021, 日本血管外科学会雑誌, 30(Suppl.) (Suppl.), SY6 - 6, Japanese


• 若年者AAAの治療戦略(EVAR vs OS) 遠隔成績からみた腹部大動脈瘤の治療戦略

  山中 勝弘, 大村 篤史, 濱口 真里, 長命 俊也, 井上 大志, 河野 敦規, 辻本 貴紀, 村上 優, 幸田 陽次郎, 中井 秀和, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2021, 日本血管外科学会雑誌, 30(Suppl.) (Suppl.), SY7 - 1, Japanese


• 腹部大動脈瘤破裂に対する治療成績向上への取り組み 術式選択よりも重要なこと

  大村 篤史, 山中 勝弘, 中井 秀和, 長命 俊也, 井上 大志, 濱口 真理, 河野 敦則, 辻本 貴紀, 幸田 陽次郎, 村上 優, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2021, 日本血管外科学会雑誌, 30(Suppl.) (Suppl.), PR5 - 1, Japanese


• 胸部大動脈ステントグラフト内挿術後proximal adverse aortic eventに対するopen surgery

  大村 篤史, 山中 勝弘, 中井 秀和, 長命 俊也, 井上 大志, 濱口 真理, 河野 敦則, 辻本 貴紀, 幸田 陽次郎, 村上 優, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2021, 日本血管外科学会雑誌, 30(Suppl.) (Suppl.), O1 - 2, Japanese


• 再大動脈基部置換術の手術成績

  幸田 陽次郎, 長命 俊也, 井上 大志, 濱口 真里, 河野 敦則, 辻本 貴紀, 村上 優, 中井 秀和, 山中 勝弘, 大村 篤史, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2021, 日本血管外科学会雑誌, 30(Suppl.) (Suppl.), O3 - 2, Japanese


• 3次元フローティング画像を用いた大動脈基部の術前計測

  辻本 貴紀, 大村 篤史, 濱口 真里, 長命 俊也, 井上 大志, 河野 敦則, 松尾 二郎, 村上 優, 幸田 陽次郎, 中井 秀和, 山中 勝弘, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2021, 日本血管外科学会雑誌, 30(Suppl.) (Suppl.), O3 - 3, Japanese


• 当院におけるKommerell憩室に対する外科的治療の成績

  村上 優, 井上 大志, 長命 俊也, 濱口 真里, 河野 敦則, 辻本 貴紀, 松尾 二郎, 幸田 陽次郎, 中井 秀和, 山中 勝弘, 大村 篤史, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2021, 日本血管外科学会雑誌, 30(Suppl.) (Suppl.), O4 - 7, Japanese


• 急性A型大動脈解離に対する出血合併症減少の取り組み

  大村 篤史, 山中 勝弘, 中井 秀和, 長命 俊也, 井上 大志, 濱口 真理, 河野 敦則, 辻本 貴紀, 幸田 陽次郎, 村上 優, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2021, 日本血管外科学会雑誌, 30(Suppl.) (Suppl.), O12 - 5, Japanese


• 胸部大動脈瘤破裂に対するThoracic Endovascular Aortic Repairの遠隔予後の検討

  中井 秀和, 大村 篤史, 長命 俊也, 井上 大志, 濱口 真里, 河野 敦則, 辻本 貴紀, 幸田 陽次郎, 村上 優, 山中 勝弘, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2021, 日本血管外科学会雑誌, 30(Suppl.) (Suppl.), O28 - 2, Japanese


• Strategies to improve outcomes for acute type A aortic dissection with cerebral malperfusion.

  Toshihito Gomibuchi, Tatsuichiro Seto, Kazuki Naito, Shuji Chino, Toru Mikoshiba, Masaki Komatsu, Haruki Tanaka, Hajime Ichimura, Takateru Yamamoto, Ko Nakahara, Noburo Ohashi, Megumi Fuke, Yuko Wada, Kenji Okada

  OBJECTIVES: We aimed to identify predictors of postoperative permanent neurological deficits (PNDs) and evaluate the early management of cerebral perfusion in patients undergoing surgical repair of acute type A aortic dissection with cerebral malperfusion. METHODS: Between October 2009 and September 2018, a total of 197 patients with acute type A aortic dissection underwent aortic replacement. Of these, 42 (21.3%) patients had an imaging cerebral malperfusion (ICM). ICM was assessed preoperatively, which also revealed whether dissected supra-aortic branch vessels were occluded or narrowed by a thrombosed false lumen. After September 2017, early reperfusion and extra-anatomic revascularization were performed in cases with ICM. RESULTS: Hospital mortality rates for cases with ICM were 4.8% (2/42). Before September 2017, PND were observed in 6 patients (54.5%) with preoperative neurological symptoms (n = 11), and 7 patients (33.3%) without neurological symptoms (n = 21) in patients with ICM. Occlusion or severe stenosis of supra-aortic branch vessels (odds ratio, 7.66; P < 0.001), regardless of preoperative clinical neurological symptoms, was a risk factor for PND. After September 2017, 7 of 10 patients with ICM underwent early reperfusion and extra-anatomic revascularization. PND did not occur in any of these 7 patients. CONCLUSIONS: Occlusion or severe stenosis of supra-aortic branch vessels is a predictor of PND risk in patients undergoing surgery for acute type A aortic dissection. Early reperfusion and extra-anatomic revascularization may reduce the risk of neurological complications in patients with ICM, with or without neurological symptoms.

  Nov. 2020, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, English, International magazine

  Scientific journal


• Valve-sparing aortic root replacement after type A aortic dissection repairs.

  Noriyuki Abe, Kenji Okada, Hiroshi Tanaka, Yutaka Okita

  OBJECTIVE: Aortic root reoperation after aortic dissection repair sometimes requires aortic root replacement. A valve-preserving technique should be applied when the aortic cusp is normal. Valve-sparing aortic root reconstruction using the reimplantation technique resolves aortic valve regurgitation, root dilatation, and pseudoaneurysm in the proximal anastomosis. Our experience in aortic root reoperation is presented. METHODS: From January 2000 to March 2019, 26 patients underwent reoperative valve-sparing aortic root reconstruction using the reimplantation technique. The time from the initial operation to reoperation was 69.3 ± 51.6 months. Aortic root reoperation was required for a fragile wall at the previous proximal anastomosis or aortic root dilatation. We aimed to stabilize the aortic root without valve regurgitation. The native aortic cusp was aggressively preserved when nearly normal. Indications included root dilatation (n = 13), pseudoaneurysm of the previous proximal anastomosis (n = 11), and aortic valve regurgitation (n = 4). RESULTS: There was no early postoperative mortality. Follow-up was 49 ± 47 months (range 4-161 months). The 3, 5, and 10-year survival was 88.9% ± 7.4%, 88.9% ± 7.4%, and 77.8% ± 12.2%, respectively. Freedom from recurrence of a greater than moderate degree of aortic valve regurgitation at 3, 5, and 10 years was 86.5% ± 8.9%, 86.5% ± 8.9%, and 86.5% ± 8.9%, respectively. One patient underwent aortic valve replacement for recurrent aortic valve regurgitation 15 months after the valve-sparing reoperation. CONCLUSIONS: Midterm outcomes of reoperative valve-sparing aortic root reconstruction using the reimplantation technique and postoperative aortic valve performance were satisfactory.

  Nov. 2020, Asian cardiovascular & thoracic annals, 218492320977981 - 218492320977981, English, International magazine

  Scientific journal


• Mitral Ebstein's Anomaly Modified with a Scarred Rhabdomyoma in Tuberous Sclerosis: An Extremely Rare Cause of Mitral Insufficiency.

  Shun Yokota, Kensuke Matsumoto, Hidekazu Tanaka, Hidekazu Nakai, Kenji Okada, Ken-Ichi Hirata

  We present an extremely rare case of mitral Ebstein's anomaly that resulted in severe mitral regurgitation (MR). A 41-year-old woman with a history of tuberous sclerosis underwent surgery. Preoperatively, it was assumed that MR had occurred due to leaflet tethering related to left ventricular posterior wall motion asynergy due to a scarred rhabdomyoma. However, surgical inspection revealed a dysplastic posterior leaflet adhering to the ventricular wall, which was completely covered by the endocardium. Both congenital mitral Ebstein's anomaly and acquired wall motion abnormality due to a scarred rhabdomyoma may have contributed to the development of severe MR in this case.

  Nov. 2020, Internal medicine (Tokyo, Japan), English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 外傷性大動脈損傷に対する外科手術および血管内治療の成績

  後竹 康子, 杉本 貴樹, 殿城 秀人, 高橋 宏明, 魚谷 健祐, 山口 雅人, 杉本 幸司, 岡田 健次

  (一社)日本胸部外科学会, Oct. 2020, 日本胸部外科学会定期学術集会, 73回, CLO10 - 1, Japanese


• 感染性大動脈疾患 大動脈食道瘻の治療戦略 消化器外科の観点から

  中村 哲, 瀧口 豪介, 山中 勝弘, 大村 篤史, 押切 太郎, 井上 武, 岡田 健次, 掛地 吉弘

  (一社)日本胸部外科学会, Oct. 2020, 日本胸部外科学会定期学術集会, 73回, CWS3 - 3, Japanese


• 急性循環不全に対する最新の補助循環治療 急性冠症候群に対する冠動脈バイパス術後ECMO導入例におけるCentral ECMOの有効性

  中井 秀和, 井上 大志, 長命 俊哉, 河野 敦則, 辻本 貴紀, 松尾 二郎, 村上 優, 山中 勝弘, 大村 篤史, 井上 武, 岡田 健次

  (一社)日本人工臓器学会, Oct. 2020, 人工臓器, 49(2) (2), S - 87, Japanese


• Impact of shaggy aorta on outcomes of open thoracoabdominal aortic aneurysm repair.

  Koki Yokawa, Yuki Ikeno, Soichiro Henmi, Katsuhiro Yamanaka, Kenji Okada, Yutaka Okita

  BACKGROUND: The aim of this study was to evaluate the impact of diffuse aortic atherosclerosis-related thrombosis, or "shaggy aorta" on the outcomes of open thoracoabdominal aortic aneurysm repair (TAAA). METHODS: From October 1999 to March 2018, 251 patients underwent open TAAA repair using segmental-staged aortic clamping. Twenty-eight patients (11.2%) received emergent or urgent operations. Patients were classified into 3 groups: dissection aneurysm (139 patients, 55.4%), degenerative aneurysm without shaggy aorta (76 patients, 30.3%), and degenerative aneurysm with shaggy aorta (36 patients, 14.3%). Shaggy aorta was assessed using enhanced computed tomography and defined as patients with atheroma thickness ≥5 mm with irregular atheroma surface. Mean follow-up was 4.3 ± 4.1 years. RESULTS: Operative mortality was 8% (20 patients) and spinal cord injury occurred in 25 patients (10.0%), 16 of whom (6.4%) had permanent neurologic dysfunction. Operative mortality was significantly worse in patients with shaggy aorta (dissection: 2.2%, non-shaggy: 6.6%, and shaggy: 33.3%, P < .001) and shaggy aorta was a significant risk factor for spinal cord injury (dissection: 7.2%, non-shaggy: 6.6%, and shaggy: 27.8%, P < .003). Multivariable analysis demonstrated that shaggy aorta was a significant risk factor for composite outcome consisted of operative mortality, spinal cord injury, and acute renal failure (odds ratio, 4.78; 95% confidence interval, 1.91-12.3, P < .001). CONCLUSIONS: Preoperative enhanced computed tomography assessment of shaggy aorta could predict high-risk patients for open TAAA repair.

  Oct. 2020, The Journal of thoracic and cardiovascular surgery, 160(4) (4), 889 - 897, English, International magazine

  Scientific journal


• Successful Double-Catheter Coil Embolization of an Iatrogenic Subclavian Artery to Internal Jugular Vein Fistula After Minimally Invasive Cardiac Surgery.

  Kazuya Matsuo, Atsushi Fujita, Masaaki Kohta, Katsuhiro Yamanaka, Takeshi Inoue, Kenji Okada, Eiji Kohmura

  It is essential to establish cardiopulmonary bypass by percutaneous insertion of a large-bore catheter via both the femoral vein and internal jugular vein (IJV) for minimally invasive cardiac surgery (MICS). Complications associated with IJV catheterization during MICS have been reported in the literature; however, vascular injury of the subclavian artery (SCA) is rare. We herein present a rare case in which an iatrogenic arteriovenous fistula (AVF) between the right SCA and IJV after MICS was successfully treated by endovascular coil embolization. A 61-year-old man who had undergone mitral valve repair by MICS 10 months before presentation was referred because of pulsatile cervical bruit and tinnitus. Radiographic examination revealed a right SCA pseudoaneurysm associated with an AVF located between the right common carotid artery and vertebral artery. The AVF was completely occluded with detachable coils using a double-catheter technique to avoid coil migration into the IJV. This technique has been used to treat high-flow or complex AVFs, including pulmonary and renal AVFs. As shown in the present case, it is also useful to treat an iatrogenic AVF between the SCA and IJV.

  Oct. 2020, Annals of vascular surgery, 68, 571.e15-571.e20, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Treatment strategies for malperfusion syndrome secondary to acute aortic dissection.

  Yutaka Okita, Kenji Okada

  OBJECTIVE: Presenting our experience of treating patients with organ malperfusion secondary to acute aortic dissection. PATIENTS: Among 383 patients who underwent aortic repair for acute type A aortic dissection from 1999 to 2017, 107 patients were operated on because of vascular complications. Fourteen patients had coronary, 50 had brain, 3 had paraplegia, 13 had superior mesenteric artery, 21 had lower limb, and 16 had combined organ malperfusion. Age was 65.8 years. RESULTS: In coronary malperfusion, three had a preoperative percutaneous coronary intervention, and two had mechanical support. All underwent repair of the aorta. Hospital mortality was 28.5%. Fifty patients had brain malperfusion. Hemiplegia was found in 28 patients, transient ischemic attack in 10, and coma in 12. The level of consciousness was severe in 12, moderate in 18, and mild in 20. Twenty-eight percent died of a stroke. Nine had direct perfusion from the right common carotid artery, and the consciousness level was improved in 5 patients. Eight patients had mesenteric malperfusion. Four patients had a central aorta repair first, and four patients had peripheral intervention first. Three patients had a bypass grafting to the superior mesenteric artery, and one had a catheter intervention. Postoperative mortality was found in four patients due to bowel necrosis and six required resections of the bowel. CONCLUSION: Acute organ malperfusion caused by the aortic dissection requires accurate and prompt diagnosis to proceed with an appropriate intervention before repairing the central aorta for preventing irreversible organ damage.

  Oct. 2020, Journal of cardiac surgery, English, International magazine

  Scientific journal


• Thoracic Endovascular Aortic Repair for Ruptured Intercostal Patch Aneurysm Following Thoracoabdominal Aortic Aneurysm Repair.

  Soichiro Henmi, Hidekazu Nakai, Katsuhiro Yamanaka, Atsushi Omura, Takeshi Inoue, Kenji Okada

  Aneurysmal change of reconstructed intercostal arteries is believed to be a rare complication after thoracoabdominal aortic repair. To our knowledge, there is no guideline or randomized controlled trials regarding intercostal patch aneurysm management. Therefore, the optimal treatment is still controversial. We describe a successful case of emergent thoracic endovascular aortic repair for ruptured intercostal patch aneurysm in an 83-year-old man following thoracoabdominal aortic aneurysm repair. Our experience illustrated that gradual expansion of large blocks of aortic wall reconstruction should be closely monitored after primary thoracoabdominal aortic replacement.

  Sep. 2020, Annals of vascular diseases, 13(3) (3), 316 - 318, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 'Obliterated right ventricle': a rare case of cardiogenic shock caused by a massive right ventricular metastasis and pulmonary embolism from laryngeal squamous cell carcinoma.

  Keiko Sumimoto, Kensuke Matsumoto, Kenji Okada, Ken-Ichi Hirata

  Sep. 2020, European heart journal, 41(35) (35), 3378 - 3378, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• ラジオ波血管内焼灼術導入後の当院における成績と術後圧迫療法における重要性

  浜口 真里, 岡田 健次, 井上 大志, 辻本 貴紀, 邊見 宗一郎, 中井 秀和, 山中 勝弘, 大村 篤史, 井上 武

  日本静脈学会, Sep. 2020, 静脈学, 31(2) (2), 193 - 193, Japanese


• 若年者腹部大動脈瘤に対する治療戦略-開腹 vs EVAR-【開腹】遠隔成績からみた腹部大動脈瘤の治療戦略 EVAR vs. open

  山中 勝弘, 大村 篤史, 孟 順, 濱口 真里, 井上 大志, 辻本 貴紀, 邉見 聡一郎, 中井 秀和, 井上 武, 岡田 健次

  (一社)日本外科学会, Aug. 2020, 日本外科学会定期学術集会抄録集, 120回, DB - 1, Japanese


• 領域横断的チームで挑む高難度手術【Video】心臓大血管手技および人工心肺を要した肺・縦隔悪性腫瘍に対する手術戦略と成績

  井上 武, 孟 順, 濱口 真理, 井上 大志, 辻本 貴紀, 邉見 宗一郎, 中井 秀和, 山中 勝弘, 大村 篤史, 岡田 健次

  (一社)日本外科学会, Aug. 2020, 日本外科学会定期学術集会抄録集, 120回, WS - 8, Japanese


• Total arch replacement in octogenarians and nonagenarians: A single-center 18-year experience.

  Yuki Ikeno, Koki Yokawa, Katsuhiro Yamanaka, Takeshi Inoue, Hiroshi Tanaka, Kenji Okada, Yutaka Okita

  BACKGROUND: This study evaluates our 18-year experience of total arch replacement in the octogenarian and nonagenarian population. METHODS: Between October 1999 and March 2018, a total of 740 patients underwent total arch replacement at our institution. A total of 139 patients were aged 80 years or more (83.1 ± 2.8 years), and 601 patients were aged less than 80 years (66.9 ± 11.3 years). Early and late outcomes were compared between the groups. RESULTS: In the group aged 80 years or more, operative mortality occurred in 12 patients (8.6%) and significantly improved over time (P = .010). Operative mortality was significantly higher in the group aged 80 years or more (P = .033) when compared with the group aged less than 80 years (4.0%). Regarding postoperative complications, deep sternal wound infection, pneumonia, and tracheostomy occurred in significantly more patients in the group aged 80 years or more. In the group aged 80 years or more, there were 52 late deaths, with 4 aortic-related deaths. Overall survival was 55.4% ± 5.0% at 5 years and 32.2% ± 6.1% at 8 years. Multivariable Cox-hazard regression analysis demonstrated that chronic kidney disease, nonelective surgery, and concurrent procedures were significant risk factors for overall survival in the group aged 80 years or more. Cumulative incidence for reoperation was significantly lower in the group aged 80 years or more (8.7% at 5 years) compared with the group aged less than 80 years (14.2% at 5 years). CONCLUSIONS: Total arch replacement was performed with an acceptable overall survival in octogenarians and nonagenarians, although operative mortality was higher than in younger patients. However, older patients had a lesser burden of reoperation compared with younger patients.

  Aug. 2020, The Journal of thoracic and cardiovascular surgery, 160(2) (2), 346 - 356, English, International magazine

  Scientific journal


• Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo.

  Hajime Ichimura, Shin Kadota, Toshihide Kashihara, Mitsuhiko Yamada, Kuniaki Ito, Hideki Kobayashi, Yuki Tanaka, Naoko Shiba, Shinichiro Chuma, Shugo Tohyama, Tatsuichiro Seto, Kenji Okada, Koichiro Kuwahara, Yuji Shiba

  Accumulating evidence suggests that human pluripotent stem cell-derived cardiomyocytes can affect "heart regeneration", replacing injured cardiac scar tissue with concomitant electrical integration. However, electrically coupled graft cardiomyocytes were found to innately induce transient post-transplant ventricular tachycardia in recent large animal model transplantation studies. We hypothesised that these phenomena were derived from alterations in the grafted cardiomyocyte characteristics. In vitro experiments showed that human embryonic stem cell-derived cardiomyocytes (hESC-CMs) contain nodal-like cardiomyocytes that spontaneously contract faster than working-type cardiomyocytes. When transplanted into athymic rat hearts, proliferative capacity was lower for nodal-like than working-type cardiomyocytes with grafted cardiomyocytes eventually comprising only relatively matured ventricular cardiomyocytes. RNA-sequencing of engrafted hESC-CMs confirmed the increased expression of matured ventricular cardiomyocyte-related genes, and simultaneous decreased expression of nodal cardiomyocyte-related genes. Temporal engraftment of electrical excitable nodal-like cardiomyocytes may thus explain the transient incidence of post-transplant ventricular tachycardia, although further large animal model studies will be required to control post-transplant arrhythmia.

  Jul. 2020, Scientific reports, 10(1) (1), 11883 - 11883, English, International magazine

  Scientific journal


• Mid-term outcomes of valve-sparing root reimplantation with leaflet repair.

  Koki Yokawa, Soichiro Henmi, Hidekazu Nakai, Katsuhiro Yamanaka, Atsushi Omura, Takeshi Inoue, Yutaka Okita, Kenji Okada

  OBJECTIVES: Valve repair for aortic insufficiency (AI) requires a tailored surgical approach determined by the leaflet and aortic disease. In this study, we used a repair-oriented system for the classification of AI, and we elucidated long-term outcomes of aortic root reimplantation with this classification system. METHODS: From 1999 to 2018, a total of 197 patients underwent elective reimplantation (mean age: 52.7 ± 17.7 years; 80% male). The aortic valve was tricuspid in 143 patients, bicuspid in 51 patients and quadricuspid in 3 patients. A total of 93 patients had type I AI (aortic dilatation), 57 patients had type II AI (cusp prolapse) and 47 patients had type III AI (restrictive). In total, 104 of the 264 patients (39%) had more than 1 identified mechanism. RESULTS: In-hospital mortality was 0.5% (1/197). Mid-term follow-up (mean follow-up duration: 5.5 years) revealed a late mortality rate of 4.2% (9/197). Aortic valve reoperation was performed on 16 patients (8.0%). Rates of freedom from aortic valve replacement and freedom from aortic valve-related events at 10 years of follow-up were 87.0 ± 4.0% and 60.6 ± 6.0%, respectively; patients with type Ib AI (98.3 ± 1.7%; 80.7 ± 7.5%) had better outcomes than patients with type III AI (59.6 ± 15.6%; 42.2 ± 13.1%, P = 0.01). In patients with types II and III AI who had bicuspid aortic valves, rates of freedom from aortic valve-related events at 5 years of follow-up were 95.2 ± 4.7% and 71.7 ± 9.1%, respectively (P = 0.03). CONCLUSIONS: This repair-oriented system for classifying AI could help to predict the durable aortic valve repair techniques. Patient selection according to the classification is particularly important for long-term durability. CLINICAL TRIAL REGISTRATION NUMBER: B190050.

  Jul. 2020, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 58(1) (1), 138 - 144, English, International magazine

  Scientific journal


• Skeletal muscle quality affects patient outcomes in acute type A aortic dissection.

  Toshihito Gomibuchi, Tatsuichiro Seto, Shuji Chino, Toru Mikoshiba, Masaki Komatsu, Haruki Tanaka, Hajime Ichimura, Takateru Yamamoto, Noburo Ohashi, Megumi Fuke, Yuko Wada, Kenji Okada

  OBJECTIVES: Although skeletal muscle quantity is linked to surgical outcomes, quality remains unexamined. In this study, we evaluated whether skeletal muscle quality and quantity could predict surgical outcomes in acute type A aortic dissection (ATAAD). METHODS: Skeletal muscle quality and quantity were evaluated using computed tomography (CT) values and the psoas muscle mass index, respectively. From May 2004 to December 2017, 324 ATAAD patients underwent aortic replacement after CT scans and psoas muscle mass index measurements. Patients were grouped into intramuscular fat (IMF; n = 55) and non-IMF (n = 269) deposition groups. RESULTS: The mean ages of the patients were 72.3 ± 9.7 and 66.8 ± 12.1 years (P = 0.002), and hospital mortality rates were 3.6% (2/55) and 7.4% (20/269; P = 0.393) for IMF and non-IMF deposition groups, respectively. IMF deposition was a risk factor for a deterioration in activities of daily living at discharge by multivariable analysis [odds ratio 0.33, 95% confidence interval (CI) 0.16-0.69; P = 0.003]. The mean follow-up was 43.9 ± 36.8 months. The 5-year survival was significantly worse for the IMF deposition group (IMF 73.8% vs non-IMF 88.2%; P = 0.010). The multivariable Cox proportional hazard analysis showed that IMF deposition significantly predicted poor survival (hazard ratio 3.26, 95% CI 1.47-7.24; P = 0.004), unlike psoas muscle mass index and age. CONCLUSIONS: Skeletal muscle quality, defined by IMF deposition, was an independent predictor of overall survival and postoperative activities of daily living dependence risk in patients undergoing surgery for ATAAD. Thus, IMF deposition may be an additional risk factor for estimating late outcomes of ATAAD surgery.

  May 2020, Interactive cardiovascular and thoracic surgery, 30(5) (5), 739 - 745, English, International magazine

  Scientific journal


• Mid-term Outcomes and Predictors of Transarterial Embolization for Type II Endoleak After Endovascular Abdominal Aortic Aneurysm Repair.

  Hiroki Horinouchi, Takuya Okada, Masato Yamaguchi, Koji Maruyama, Koji Sasaki, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Ryota Kawasaki, Yoshikatsu Nomura, Atsushi Omura, Kenji Okada, Koji Sugimoto, Takamichi Murakami

  PURPOSE: To evaluate the mid-term outcomes of transarterial embolization (TAE) for type II endoleak after endovascular abdominal aortic aneurysm repair (EVAR) and investigate the predictors of sac enlargement after embolization. MATERIALS AND METHODS: We conducted a retrospective analysis of 55 patients [48 men and 7 women, median age 79.0 (interquartile ranges 74-82) years] who underwent TAE for type II endoleak from 2010 to 2018. The aneurysmal sac enlargement, endoleaks, aneurysm-related adverse event rate, and reintervention rate were evaluated. Patients' characteristics and clinical factors were evaluated for their association with sac enlargement. RESULTS: Fifty-five patients underwent TAE with technical success and were subsequently followed for a median of 636 (interquartile ranges 446-1292) days. The freedom from sac enlargement rates at 1, 3, and 5 years was 73.2%, 32.0%, and 26.7%, respectively. After initial TAE, the recurrent type II, delayed type I, and occult type III endoleak were identified in 39 (71%), 5 (9%), and 3 (5%) patients, respectively. Although a patient had aorto-duodenal fistula, there was no aneurysm-related death. The freedom from reintervention rates was 84.6%, 35.7%, and 17.0%, respectively. In the multivariate analysis, sac diameter > 55 mm at initial TAE (hazard ratios, 3.23; 95% confidence intervals, 1.22-8.58; P < 0.05) was a significant predictor of sac enlargement. CONCLUSION: TAE for type II endoleak was not effective in preventing sac enlargement, and reinterventions were required among the mid-term follow-up. The sac diameter > 55 mm at initial TAE was a significant predictor of sac enlargement.

  May 2020, Cardiovascular and interventional radiology, 43(5) (5), 696 - 705, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Mechanical Thrombectomy for Postoperative Stroke in a Patient with Acute Aortic Dissection Type A.

  Hiromu Kehara, Syuichi Urashita, Toshihito Gomibuchi, Kazunori Komatsu, Kouhei Takahashi, Katsuaki Tsukioka, Takamitsu Terasaki, Tetsuya Kono, Naomichi Wada, Yukinari Kakizawa, Jun-Ichi Koyama, Kenji Okada

  Mechanical thrombectomy has been proposed to expand the treatment time window and enhance revascularization. However, it is unclear whether its use can be extended to patients with occlusions in acute aortic dissection, especially the thoracic aorta. A 55-year-old man underwent graft replacement for acute aortic dissection type A. On postoperative day 2, he developed stroke and computed tomography showed occlusion of the right middle cerebral artery. Mechanical thrombectomy was performed by transbrachial approach. Although successful recanalization was achieved, he suffered hemorrhagic stroke. Since there is no other effective treatment and the neurologic outcome with conservative management is poor, we consider mechanical thrombectomy to be a viable therapeutic option for the treatment of postoperative stroke in patients with acute aortic dissection type A. However, further study is warranted regarding the safety of this technique.

  Apr. 2020, NMC case report journal, 7(2) (2), 71 - 74, English, Domestic magazine


• 大動脈基部病変に対する治療戦略 大動脈基部膿瘍に対する大動脈基部再建の方法及び成績

  辻本 貴紀, 大村 篤史, 殿城 秀斗, 孟 順, 井上 大志, 浜口 真里, 陽川 孝樹, 邉見 宗一郎, 中井 秀和, 山中 勝弘, 井上 武, 岡田 健次

  (NPO)日本心臓血管外科学会, Mar. 2020, 日本心臓血管外科学会学術総会抄録集, 50回, SY2 - 8, Japanese


• 重症大動脈弁狭窄症に対する外科的大動脈弁置換術の術前frail評価の有用性

  浜口 真里, 岡田 健次, 孟 順, 井上 大志, 辻本 貴紀, 陽川 孝樹, 邊見 宗一郎, 中井 秀和, 山中 勝弘, 大村 篤史, 井上 武

  (NPO)日本心臓血管外科学会, Mar. 2020, 日本心臓血管外科学会学術総会抄録集, 50回, PR19 - 5, Japanese


• 当院の急性A型大動脈解離の手術成績

  大村 篤史, 中井 秀和, 邉見 宗一郎, 孟 順, 井上 大志, 浜口 真理, 辻本 貴紀, 陽川 孝樹, 山中 勝弘, 井上 武, 岡田 健次

  (NPO)日本心臓血管外科学会, Mar. 2020, 日本心臓血管外科学会学術総会抄録集, 50回, PR24 - 2, Japanese


• 遠隔予後から見た70歳未満への冠動脈バイパス術における動脈グラフトの意義

  井上 武, 孟 順, 濱口 真理, 井上 大志, 辻本 貴紀, 陽川 孝樹, 邉見 宗一郎, 中井 秀和, 山中 勝弘, 大村 篤史, 岡田 健次

  (NPO)日本心臓血管外科学会, Mar. 2020, 日本心臓血管外科学会学術総会抄録集, 50回, O7 - 4, Japanese


• 当院の肺動脈血栓内膜摘除術の成績

  中井 秀和, 殿城 秀人, 孟 順, 濱口 真里, 井上 大志, 辻本 貴紀, 陽川 孝樹, 邉見 宗一郎, 山中 勝弘, 大村 篤史, 井上 武, 岡田 健次

  (NPO)日本心臓血管外科学会, Mar. 2020, 日本心臓血管外科学会学術総会抄録集, 50回, O11 - 2, Japanese


• ファロー四徴症術後遠隔期肺動脈弁逆流に対する肺動脈弁置換術の予後

  孟 順, 殿城 秀人, 濱口 真里, 井上 大志, 辻本 貴紀, 陽川 孝樹, 邉見 宗一郎, 中井 秀和, 山中 勝弘, 大村 篤史, 井上 武, 岡田 健次

  (NPO)日本心臓血管外科学会, Mar. 2020, 日本心臓血管外科学会学術総会抄録集, 50回, P44 - 6, Japanese


• 胸腹部大動脈瘤術後急性腎障害と早期遠隔期成績の検討

  邉見 宗一郎, 孟 順, 濱口 真里, 井上 大志, 辻本 貴紀, 陽川 孝樹, 中井 秀和, 山中 勝弘, 大村 篤史, 井上 武, 岡田 健次

  (NPO)日本心臓血管外科学会, Mar. 2020, 日本心臓血管外科学会学術総会抄録集, 50回, P52 - 3, Japanese


• Atypical Type 2 Endoleak from an Artery Supplying the Psoas Major Muscle Following Endovascular Repair in a Case of Isolated Common Iliac Artery Aneurysm.

  Hamada MAS, Okada T, Yamaguchi M, Gotake Y, Okada K, Sugimoto K, Murakami T

  Feb. 2020, Interventional Radiology, 5(1) (1), 19 - 22, English

  [Refereed]

  Scientific journal


• 当院におけるIliac Branch Endoprosthesisを用いたステントグラフト内挿術の成績

  濱口 真里, 中井 秀和, 殿城 秀斗, 孟 順, 井上 大志, 辻本 貴紀, 邊見 宗一郎, 山中 勝弘, 大村 篤史, 井上 武, 岡田 健次, 山口 雅人, 杉本 幸司

  (NPO)日本血管外科学会, 2020, 日本血管外科学会雑誌, 29(Suppl.) (Suppl.), P8 - 4, Japanese


• 慢性血栓塞栓症性肺高血圧症に対する肺動脈血栓内膜摘除術の脳合併症の検討

  中井 秀和, 大村 篤史, 殿城 秀人, 孟 順, 濱口 真里, 井上 大志, 辻本 貴紀, 邉見 宗一郎, 山中 勝弘, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2020, 日本血管外科学会雑誌, 29(Suppl.) (Suppl.), SY5 - 4, Japanese


• 二尖弁に対するReimplantation法の形態学的検討

  辻本 貴紀, 殿城 秀斗, 孟 順, 濱口 真里, 井上 大志, 邉見 宗一郎, 中井 秀和, 山中 勝弘, 大村 篤史, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2020, 日本血管外科学会雑誌, 29(Suppl.) (Suppl.), SY7 - 5, Japanese


• 胸部下行大動脈解離に対するTEVAR後の再手術成績

  井上 武, 殿城 秀斗, 孟 順, 濱口 真理, 井上 大志, 辻本 貴紀, 邉見 宗一郎, 中井 秀和, 山中 勝弘, 大村 篤史, 岡田 健次

  (NPO)日本血管外科学会, 2020, 日本血管外科学会雑誌, 29(Suppl.) (Suppl.), OP5 - 2, Japanese


• Tear-oriented plus aggressive arch strategy for acute type A aortic dissection(和訳中)

  大村 篤史, 山中 勝弘, 中井 秀和, 邉見 宗一郎, 殿城 秀斗, 孟 順, 濱口 真理, 井上 大志, 辻本 貴紀, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2020, 日本血管外科学会雑誌, 29(Suppl.) (Suppl.), OP15 - 2, English


• 大動脈関連感染における有茎大網充填術および広背筋・大胸筋皮弁移植術の治療成績

  孟 順, 邉見 宗一郎, 殿城 秀斗, 濱口 真里, 井上 大志, 辻本 貴紀, 中井 秀和, 山中 勝弘, 大村 篤史, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2020, 日本血管外科学会雑誌, 29(Suppl.) (Suppl.), OP16 - 1, Japanese


• 慢性解離性大動脈瘤手術の遠隔成績

  山中 勝弘, 殿城 秀斗, 孟 順, 濱口 真里, 井上 大志, 辻本 貴紀, 邉見 宗一郎, 中井 秀和, 大村 篤史, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2020, 日本血管外科学会雑誌, 29(Suppl.) (Suppl.), SF1 - 3, Japanese


• 炎症性血管疾患患者に対する冠動脈バイパス術の成績

  井上 大志, 大村 篤史, 殿城 秀人, 孟 順, 濱口 真里, 辻本 貴紀, 邉見 宗一郎, 中井 秀和, 山中 勝弘, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2020, 日本血管外科学会雑誌, 29(Suppl.) (Suppl.), SF2 - 2, Japanese


• 大動脈感染性疾患の治療成績

  山中 勝弘, 殿城 秀斗, 孟 順, 濱口 真里, 井上 大志, 辻本 貴紀, 邉見 宗一郎, 中井 秀和, 大村 篤史, 井上 武, 岡田 健次

  (NPO)日本血管外科学会, 2020, 日本血管外科学会雑誌, 29(Suppl.) (Suppl.), SF15 - 1, Japanese


• 当院におけるIliac Branch Endoprosthesisを用いたステントグラフト内挿術の成績

  濱口 真里, 中井 秀和, 殿城 秀斗, 孟 順, 井上 大志, 辻本 貴紀, 邊見 宗一郎, 山中 勝弘, 大村 篤史, 井上 武, 岡田 健次, 山口 雅人, 杉本 幸司

  (NPO)日本血管外科学会, 2020, 日本血管外科学会雑誌, 29(Suppl.) (Suppl.), P8 - 4, Japanese


• Effects of acute-phase multidisciplinary rehabilitation on unplanned readmissions after cardiac surgery.

  Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Yasunori Tsuboi, Kodai Komaki, Kumiko Wakida, Yasuko Gotake, Kazuhiro P Izawa, Yoshitada Sakai, Kenji Okada

  OBJECTIVES: The provision of inpatient programs that reduce the incidence of readmission after cardiac surgery remains challenging. Investigators have focused on multidisciplinary cardiac rehabilitation (CR) because it reduces the postoperative readmission rate; however, most previous studies used outpatient models (phase II CR). We retrospectively investigated the effect of comprehensive multidisciplinary interventions in the acute inpatient phase (phase I CR) on unplanned hospital readmission. METHODS: In a retrospective cohort study, we compared consecutive patients after cardiac surgery. We divided them into the multidisciplinary CR (multi-CR) group or conventional exercise-based CR (conv-CR) group according to their postoperative intervention during phase I CR. Multi-CR included psychological and educational intervention and individualized counseling in addition to conv-CR. The primary outcome was unplanned readmission rates between the groups. A propensity score-matching analysis was performed to minimize selection biases and the differences in clinical characteristics. RESULTS: In our cohort (n = 341), 56 (18.3%) patients had unplanned readmission during the follow-up period (median, 419 days). Compared with the conv-CR group, the multi-CR group had a significantly lower unplanned readmission rate (multivariable regression analysis; hazard ratio, 0.520; 95% confidence interval, 0.28-0.95; P = .024). A Kaplan-Meier analysis of our propensity score-matched cohort showed that, compared with the conv-CR group, the multi-CR group had a significantly lower incidence of readmission (stratified log-rank test, P = .041). CONCLUSIONS: In phase I, compared to conv-CR alone, multi-CR reduced the incidence of unplanned readmission. Early multidisciplinary CR can reduce hospitalizations and improve long-term prognosis after cardiac surgery.

  Dec. 2019, The Journal of thoracic and cardiovascular surgery, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Descending aortic replacement for intimal angiosarcoma.

  Koki Yokawa, Takeshi Inoue, Katsuhiro Yamanaka, Kenji Okada

  Aortic angiosarcoma is an exceedingly rare clinical entity. A significant delay in diagnosis can occur due to its rareness and lack of specific clinical manifestation. A 71-year-old woman was admitted to the emergency department owing to an acute episode of abdominal pain. A computed tomography (CT) scan showed thoraco-abdominal aortic occlusion and splenic infarction. The patient was initially treated with descending aortic replacement for degenerative atherothrombotic aneurysm. An FDG-positron emission tomography-CT scan and biopsy ultimately confirmed the diagnosis of aortic angiosarcoma. This case highlights the difficulties of making an early diagnosis of aortic angiosarcoma.

  Dec. 2019, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 56(6) (6), 1204 - 1205, English, International magazine

  Scientific journal


• 破裂性大動脈瘤に対する治療戦略 下行大動脈瘤破裂に対する胸部ステントグラフト内挿術の早期および遠隔成績

  中井 秀和, 殿城 秀人, 孟 順, 井上 大志, 陽川 孝樹, 邉見 宗一郎, 後竹 康子, 山中 勝弘, 大村 篤史, 井上 武, 山口 雅人, 杉本 幸司, 岡田 健次

  (一社)日本脈管学会, Oct. 2019, 脈管学, 59(Suppl.) (Suppl.), S133 - S133, Japanese

  [Refereed]


• Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績

  元津 倫幸, 山口 雅人, Hamada Mostafa, 佐々木 康二, 堀之内 宏樹, 上嶋 英介, 岡田 卓也, 祖父江 慶太郎, 後竹 康子, 中井 秀和, 山中 勝弘, 大村 篤史, 岡田 健次, 杉本 幸司, 村上 卓道

  (一社)日本脈管学会, Oct. 2019, 脈管学, 59(Suppl.) (Suppl.), S175 - S175, Japanese

  [Refereed]


• 腹部大動脈瘤ステントグラフト内挿術後open conversionに至った症例の検討

  山中 勝弘, 大村 篤史, 中井 秀和, 邉見 宗一郎, 陽川 孝樹, 岡田 卓也, 山口 雅人, 杉本 幸司, 井上 武, 岡田 健次

  (一社)日本脈管学会, Oct. 2019, 脈管学, 59(Suppl.) (Suppl.), S179 - S179, Japanese

  [Refereed]


• Hemolytic characteristics of three suctioning systems for use with a newly developed cardiopulmonary bypass system.

  Yuki Michinaga, Tamaki Takano, Takamitsu Terasaki, Souma Miyazaki, Noritoshi Kikuchi, Kenji Okada

  INTRODUCTION: We have been developing a closed-circuit cardiopulmonary bypass (CPB) system ("Dihead CPB") for application during coronary artery bypass grafting (CABG) and valve surgery. To strive for minimal hemolysis during Dihead CPB, we compared the hemolysis caused by three different suction systems and performed a clinical study with the newly applied suction system. MATERIALS & METHODS: We evaluated the hemolysis caused by roller-pump suction, the SmartSuction® Harmony® and wall suction systems with respect to suction speed and compared the systems by means of in vitro studies. A clinical study was also performed on 15 volunteers to assess hemolysis and the adequacy of the newly applied suction system with Dihead CPB. RESULTS: Pressure inside the suction cannula was -22.5 ± 0.1 mmHg at a maximum flow of 1.5 L/min for roller-pump suction and -43.4 ± 0.1 mmHg at -150 mmHg of the set vacuum pressure of wall suction. With the SmartSuction, the pressure inside the cannula varied from -76.3 ± 1.0 to -130.3 ± 1.5 mmHg, depending on suctioning conditions. Suction speed (to suction 50 ml of blood) was fastest with the SmartSuction (69.7 ± 3.58 s) whereas, with roller suction, it was 117.3 ± 8.47 s and with wall suction 96.9 ± 7.10 s. The SmartSuction had the highest hemolysis rate (2.00 ± 0.33%) vs. 0.61 ± 0.10% for roller suction and 0.41 ± 0.11% for wall suction (p<0.001). The clinical study with wall suction showed no significant increase in plasma free hemoglobin during or after CPB compared with before surgery. CONCLUSIONS: Wall suction had less hemolysis than roller suction or the SmartSuction in the in vitro study and the clinical study with wall suction showed efficient suction speed and acceptable hemolysis, suggesting that Dihead CPB with wall suction is feasible for CABG.

  Mar. 2019, Perfusion, 34(2) (2), 136 - 142, English, International magazine

  Scientific journal


• Establishment of a Healthcare System for Patients With Adult Congenital Heart Disease in Collaboration With Children's Hospital - The Nagano Model.

  Hirohiko Motoki, Satoshi Yasukochi, Kiyohiro Takigiku, Kohta Takei, Toru Okamura, Kazuhiro Kimura, Masatoshi Minamisawa, Ayako Okada, Tatsuya Saigusa, Soichiro Ebisawa, Tatsuichiro Seto, Morio Shoda, Kenji Okada, Koichiro Kuwahara

  BACKGROUND: Despite the best efforts of pediatricians, healthcare for adult patients with congenital heart disease (ACHD) has proven challenging because of the increased numbers. This study presents the process of establishing an ACHD care system as a collaborative effort between Shinshu University Hospital and Nagano Children's Hospital. Methods and Results: Establishing an outpatient clinic for transition, a cooperation agreement for in-patient care between the 2 hospitals, and quality management of diagnostic imaging and educational meetings for adult cardiologists were the 3 major challenges. Of the 99 patients who visited the transition clinic in the children's hospital between May 2014 and December 2016, 3 returned to the pediatrician's clinic. Between June 2013 and December 2017, 273 patients visited the ACHD center in Shinshu University Hospital. Until December 2017, mortality and fatal arrhythmia were noted in 3 and 2 cases, respectively. Catheter ablation for arrhythmia was performed in 12 cases, and 4 cases of pregnancy with moderate/severe ACHD or estimated as high risk were managed with healthy livebirths. Surgical interventions for moderate/severe ACHD were performed in collaboration with the children's hospital or Sakakibara Heart Institute. CONCLUSIONS: Patients were successfully transferred to adult cardiology departments. Surgical and nonsurgical interventions for ACHD were provided. Collaboration between adult and pediatric cardiologists assists in the establishment of healthcare systems for ACHD.

  Jan. 2019, Circulation journal : official journal of the Japanese Circulation Society, 83(2) (2), 424 - 431, English, Domestic magazine

  Scientific journal


• EVARにおける内腸骨動脈血流温存の意義・適応 腹部ステントグラフト内挿術における内腸骨動脈塞栓の影響

  後竹 康子, 河本 達也, 孟 順, 陽川 孝樹, 邊見 宗一郎, 中井 秀和, 山中 勝弘, 井上 武, 山口 雅人, 岡田 健次

  (NPO)日本血管外科学会, 2019, 日本血管外科学会雑誌, 28(Suppl.) (Suppl.), PR4 - 6, Japanese


• Analysis of surgical treatment of Masaoka stage III-IV thymic epithelial tumors.

  Kazutoshi Hamanaka, Tsutomu Koyama, Shunichiro Matsuoka, Tetsu Takeda, Kentaro Miura, Kyoko Yamada, Akira Hyogotani, Tatsuichiro Seto, Kenji Okada, Ken-Ichi Ito

  OBJECTIVE: The purpose of this study is to elucidate the outcomes after surgical resection of Masaoka stage III-IV thymic epithelial tumors. METHODS: We retrospectively reviewed patients with Masaoka stage III-IV thymic epithelial tumor who underwent surgical resection from January 1995 to January 2017. The clinicopathological features, surgical procedures, and postoperative outcomes were investigated. RESULTS: Thirteen patients with thymoma and 18 patients with thymic carcinoma were assessed. The postoperative Masaoka stages were III/IVa/IVb = 8/4/1 in thymoma and III/IVa/IVb = 11/2/5 in thymic carcinoma. In patients with thymoma, the World Health Organization pathological subtypes were A/B1/B2/B3 = 2/1/4/6. We performed combined resection and reconstruction for brachiocephalic vein or superior vena cava in 3 patients with thymoma and 7 patients with thymic carcinoma. In all patients, the patency rate of the grafts was very low for the left brachiocephalic vein and well maintained for the right brachiocephalic vein. Macroscopically and pathologically complete resection was achieved in 11 and 6 patients with thymoma, respectively, and in 15 and 9 patients with thymic carcinoma, respectively. The 10-year survival rates were 85.7% in thymoma and 70.3% in thymic carcinoma. Postoperative recurrences were observed in 2 and 9 patients with thymoma and thymic carcinoma, respectively. Recurrences were observed within 5 and 10 years after surgery in 2 patients with thymoma and within 2 years in all patients with thymic carcinoma. CONCLUSIONS: Patients with Masaoka stage III-IV thymic epithelial tumor showed relatively favorable long-term survival after surgical treatment. Therefore, aggressive surgical resection for complete resection may be a treatment option for these conditions.

  Dec. 2018, General thoracic and cardiovascular surgery, 66(12) (12), 731 - 735, English, Domestic magazine

  Scientific journal


• Impact of Frailty on Outcomes in Acute Type A Aortic Dissection.

  Toshihito Gomibuchi, Tatsuichiro Seto, Masaki Komatsu, Haruki Tanaka, Hajime Ichimura, Takateru Yamamoto, Noburo Ohashi, Yuko Wada, Kenji Okada

  BACKGROUND: Although frailty is used to predict morbidity and mortality, its effect on the outcomes of acute type A aortic dissection has not been examined. Therefore, the objective of this study was to evaluate the role of frailty in predicting postoperative morbidity and mortality of patients with acute type A aortic dissection. METHODS: A retrospective analysis of a prospectively maintained database was undertaken for all patients (n = 310) undergoing aortic surgery between May 2004 and March 2017. Frailty was evaluated using an index consisting of age more than 70 years, body mass index less than 18.5 kg/m2, serum creatinine greater than 1.2 mg/dL, anemia, history of stroke, hypoalbuminemia, and the psoas muscle area index. One point was given for each criterion met, for a frailty score between 0 and 7. Frailty was defined as a score of 3 or more. RESULTS: Of all patients, 106 (34.2%) were defined as frail. Inhospital mortality rates of frail versus nonfrail patients were not significantly different (10.4% versus 8.3%, respectively; p = 0.54). Incidences of postoperative major morbidities without reexploration for bleeding were also not statistically different. Five-year survival rates were significantly worse for frail patients than for nonfrail patients (57.7% versus 85.1%, respectively; p = 0.0001). A frailty score of 3 or greater was associated with late mortality, and long-term outcomes were clearly stratified by frailty score. CONCLUSIONS: Frailty, as defined using a seven-component frailty index, can serve as an independent predictor of the risk of late mortality for patients undergoing surgery for acute type A aortic dissection. Such frailty markers, all of which are easily assessed preoperatively, may provide valuable information for patient counseling and risk stratification before aortic surgery.

  Nov. 2018, The Annals of thoracic surgery, 106(5) (5), 1349 - 1355, English, International magazine

  Scientific journal


• Peripartum Iliac Arterial Aneurysm and Rupture in a Patient with Vascular Ehlers-Danlos Syndrome Diagnosed by Next-Generation Sequencing.

  Norimichi Koitabashi, Tomomi Yamaguchi, Daisuke Fukui, Takahide Nakano, Atsushi Umeyama, Kazuyoshi Toda, Ryuichi Funada, Masumi Ishikawa, Rie Kawamura, Kenji Okada, Atsushi Hatamochi, Tomoki Kosho, Masahiko Kurabayashi

  Vascular Ehlers-Danlos syndrome (vEDS), a genetic disorder caused by mutations in procollagen type III gene (COL3A1), may lead to fatal vascular complication during peripartum period because of the arterial fragility. We experienced a case of vEDS with peripartum life-threatening arterial rapture diagnosed by next-generation sequencing (NGS) and successfully treated the vascular complications. A 25-year-old female in pregnancy at 34 weeks had sudden and acute pain in the left lower abdomen. After successful delivery, her computed tomography scan showed a dissecting aneurysm of the left common iliac artery (CIA). Four days after delivery, she presented in hemorrhagic shock induced by arterial rupture in the CIA. Since her clinical presentations inferred vEDS even in the absence of familial history, we performed NGS-based genetic screening for inherited connective tissue disorders including vEDS with informed consent. Even though we started intensive medication, her iliac aneurysm was progressively enlarging within 3 weeks. After an urgent molecular diagnosis for vEDS (a splice-site mutation), cautious endovascular therapy for her CIA aneurysm was successfully performed. This is the first report for pretreatment molecular diagnosis of vEDS using NGS in an emergent situation of severe vascular complications.

  Sep. 2018, International heart journal, 59(5) (5), 1180 - 1185, English, Domestic magazine

  Scientific journal


• Valve-sparing aortic root replacement after double-switch operation for corrected transposition of the great arteries in a patient with ulcerative colitis.

  Toshihito Gomibuchi, Kenji Okada, Tatsuichiro Seto, Yutaka Okita

  Mosby Inc., Jun. 2018, The Journal of thoracic and cardiovascular surgery, 155(6) (6), e175-e176 - e176, English, International magazine

  Scientific journal


• Intraoperative detection of inferior vena caval tumor thrombus extending from metastatic lymph node of renal cell carcinoma using ultrasonography.

  Tomonori Minagawa, Daisuke Fukui, Kunihiko Shingu, Teruyuki Ogawa, Kenji Okada, Osamu Ishizuka

  Springer Tokyo, Apr. 2018, Journal of medical ultrasonics (2001), 45(2) (2), 367 - 370, English, Domestic magazine

  Scientific journal


• Nontraumatic Proximal Ulnar Artery Pseudoaneurysm Mimicking a Soft Tissue Tumor in Image Modality.

  Hiromu Kehara, Yuko Wada, Daisuke Fukui, Kunihiko Shingu, Tatsuichiro Seto, Kenji Okada

  Aneurysm of the proximal ulnar artery is extremely rare. Ultrasonography, computed tomography, and magnetic resonance imaging generally provide accurate diagnosis of aneurysm. A 29-year-old woman who had undergone an excision biopsy of a mass in her right arm by an orthopedic surgeon was referred to our department. We resected the mass and interposed it with a reversed great saphenous vein. Histopathological examination suggested that the mass was a pseudoaneurysm consisting of organized thrombi with recanalization. Clinicians should be aware of the possibility of misdiagnosis of soft tissue tumor in cases of pseudoaneurysm, especially if imaging examination reveals a density consistent with organized thrombus with recanalization.

  Feb. 2018, Annals of vascular surgery, 47, 279.e1-279.e5, English, International magazine

  Scientific journal


• Increased Expression of Y-Box-Binding Protein-1 in Hind-Limb Muscles During Regeneration from Ischemic Injury in Mice.

  Megumi Fuke, Makoto Narita, Yuko Wada, Tatsuichiro Seto, Kenji Okada, Jun Nakayama, Hiroto Izumi, Ken-Ichi Ito

  Critical limb ischemia (CLI) is the most severe complication of peripheral arterial disease (PAD). Understanding the molecular mechanisms underlying tissue repair after CLI is necessary for preventing PAD progression. Y-box binding protein-1 (YB-1) regulates the expression of many genes in response to environmental stresses. We aimed to determine whether YB-1 is involved in ischemic muscle regeneration. A mouse ischemic hind-limb model was generated; namely, the femoral, saphenous, and popliteal arteries in the left hind limb were ligated. The right hind limb, with skin incisions alone, served as control. Hind limbs (n = 3-5 for each time point) were examined on day 0 (before the operation) and on postoperative days 1, 2, 7, 10, and 14, and the biceps femoris, adductor, rectus femoris, and gracilis muscles were subjected to histopathological and immunohistochemical analyses. In ischemic limbs, myogenesis, triggered by an increase in myotubes, began on day 7; thereafter, regenerated muscles gradually increased in volume. RT-PCR analysis showed that YB-1 mRNA levels were increased in the limbs after ischemic injury, peaked on day 2, and subsequently decreased. On day 7, expression levels of MyoD and alpha-smooth muscle actin (αSMA) mRNAs were significantly higher in ischemic muscles than in control muscles. Immunohistochemical analysis revealed increased YB-1 immunoreactivity in myoblasts and myotubes on day 7, which was decreased by day 14. The immunoreactive αSMA and smooth muscle myosin heavy chain were transiently increased in myotubes. This is the first report showing the increased expression of YB-1 during muscle regeneration after ischemic injury.

  Jan. 2018, The Tohoku journal of experimental medicine, 244(1) (1), 53 - 62, English, Domestic magazine

  Scientific journal


• Surgical Repair of Cervical Aortic Arch With Brain Circulation Anomaly Through Clamshell Incision.

  Toshihito Gomibuchi, Tatsuichiro Seto, Takateru Yamamoto, Ko Nakahara, Noburo Ohashi, Yoshinori Ohtsu, Yuko Wada, Daisuke Fukui, Kenji Okada

  Sep. 2017, The Annals of thoracic surgery, 104(3) (3), e235-e237 - E237, English, International magazine

  Scientific journal


• Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model.

  Tatsuki Ogasawara, Satomi Okano, Hajime Ichimura, Shin Kadota, Yuki Tanaka, Itsunari Minami, Motonari Uesugi, Yuko Wada, Naoto Saito, Kenji Okada, Koichiro Kuwahara, Yuji Shiba

  Aug. 2017, Scientific reports, 7(1) (1), 8630 - 8630, English, International magazine

  Scientific journal


• [Brain Protection for Shaggy Aorta During Aortic Arch Surgery].

  Kenji Okada

  Although short and long-term outcomes of aortic surgeries have been improving over the past decade, the procedure is likely to be asscociated with life-threatening complications such as neurological deficits caused by suboptimal brain protection or heavily diseased aorta. Contemporary strategies for brain protection are deep hypothermic arrest with or without retrograde cerebral perfusion retrograde cerebral perfusion or selective antegrade cerebral perfusion. At the moment, majority of evidences failed to show the superiority of selective antegrade cerebral perfusion to retrograde one. Shaggy aorta( atherothrombotic aorta) was defined as very extensive atheromatous disease with diffuse ulcers associated with soft, loosely held debris and a paucity of actual thrombus and is the prototypical potential embolic source for neurological deficits. Non-physiological flow during cardiopulmonary bypass causes the detachment of atheroma and consequently the debris was washed away into the carotid arteries. Therefore, meticulous selection of cannulation site and type of cannula (a dispersion cannula) and complete exclusion of the diseased aorta contributed to avoiding permanent neurological deficits even when atherothrombotic aorta was present. Shaggy aorta combined with leukoaraiosis, extracranial carotid artery stenosis, and prolonged cardiopulmonary bypass time exponentially increased postoperative transient neurological deficits in patients undergoing total aortic arch replacement, and may therefore deserve special attention.

  Jul. 2017, Kyobu geka. The Japanese journal of thoracic surgery, 70(8) (8), 571 - 577, Japanese, Domestic magazine

  Scientific journal


• Shaggy aorta : 大動脈手術でいかに脳合併症を予防するか (特集 胸部外科領域における合併症予防のための周術期管理) -- (心臓血管領域)

  岡田 健次

  Jul. 2017, 胸部外科 = The Japanese journal of thoracic surgery, 70(8) (8), 571-577


• Biventricular support using a centrifugal pump in a 6 year old with fulminant myocarditis.

  Hiromu Kehara, Tamaki Takano, Takamitsu Terasaki, Kenji Okada

  Jun. 2017, Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 20(2) (2), 166 - 169, English, Domestic magazine

  Scientific journal


• [Current Status of Thoracic Endovascular Aortic Repair in Our Institution].

  Daisuke Fukui, Kenji Okada

  Within 8-year period between 2009 and 2016, we treated 215 patient with a strategy of primary thoracic endovascular aortic repair( TEVAR). In-hospital mortality was 4.4%( 8 cases). Thirty-two emergency cases was included and we treated 23 cases of zone 0 debranching TEVAR with chimney techinique in this period. In recent 2-year period between 2015 and 2016, we treated 44 cases of TEVAR without type I a endoleaks with 0% mortality(most of the them was zone 2~3 TEVAR in this period) on the one hand, and the number of open surgery for thoracic aorta was 80 on the other. TEVAR was also indicated for emergency and high risk cases even if their anatomical conditions were outside of instruction for use, and utilized for bridging or staged therapy for open surgery in our series. Standardization and refinement of endovascular procedures is considered to be important to improvement outcomes, and hybrid therapy or back up of open surgery should be collaborated with TEVAR for thoracic aortic aneurysm treatment.

  Apr. 2017, Kyobu geka. The Japanese journal of thoracic surgery, 70(4) (4), 244 - 250, Japanese, Domestic magazine

  Scientific journal


• 胸部大動脈瘤に対するステントグラフト治療の工夫と現状 (特集 胸部大動脈に対するステントグラフト治療up-to-date)

  福井 大祐, 岡田 健次

  Apr. 2017, 胸部外科 = The Japanese journal of thoracic surgery, 70(4) (4), 244-250


• Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts.

  Yuji Shiba, Toshihito Gomibuchi, Tatsuichiro Seto, Yuko Wada, Hajime Ichimura, Yuki Tanaka, Tatsuki Ogasawara, Kenji Okada, Naoko Shiba, Kengo Sakamoto, Daisuke Ido, Takashi Shiina, Masamichi Ohkura, Junichi Nakai, Narumi Uno, Yasuhiro Kazuki, Mitsuo Oshimura, Itsunari Minami, Uichi Ikeda

  Oct. 2016, Nature, 538(7625) (7625), 388 - 391, English, International magazine

  Scientific journal


• Closed Circuit Systemの低侵襲化に関する検討

  道永 祐希, 高野 環, 寺崎 貴光, 宮嵜 聡磨, 菊池 紀敏, 岡田 健次

  (一社)日本人工臓器学会, Oct. 2016, 人工臓器, 45(2) (2), S - 86, Japanese


• Surgical strategy for aortic prosthetic graft infection with (18)F-fluorodeoxyglucose positron emission tomography/computed tomography.

  Katsuhiro Yamanaka, Takashi Matsueda, Shunsuke Miyahara, Yoshikatsu Nomura, Toshihito Sakamoto, Naoto Morimoto, Takeshi Inoue, Masamichi Matsumori, Kenji Okada, Yutaka Okita

  A 30-year-old man with Marfan syndrome who underwent Crawford type II extension aneurysm repair about 9 years ago was referred to our hospital with persistent fever. Computed tomography (CT) showed air around the mid-descending aortic prosthetic graft. Because the air did not disappear in spite of intravenous antibiotics, (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) was performed. FDG-PET/CT revealed four high-uptake lesions. After dissecting the aortic graft particularly focusing on the high-uptake lesions, this patient underwent in situ graft re-replacement of descending aortic graft with a rifampicin-bonded gelatin-impregnated Dacron graft and omentopexy. The patient remains well without recurrent infection at 3 months after surgery.

  Sep. 2016, General thoracic and cardiovascular surgery, 64(9) (9), 549 - 51, English, Domestic magazine

  Scientific journal


• Glucagon-like peptide-1 prevented abdominal aortic aneurysm development in rats.

  Jie Yu, Keisuke Morimoto, Wulan Bao, Zhenhai Yu, Yutaka Okita, Kenji Okada

  Sep. 2016, Surgery today, 46(9) (9), 1099 - 107, English, Domestic magazine

  Scientific journal


• Endogenous superoxide dismutase activation by oral administration of riboflavin reduces abdominal aortic aneurysm formation in rats.

  Zhenhai Yu, Keisuke Morimoto, Jie Yu, Wulan Bao, Yutaka Okita, Kenji Okada

  Sep. 2016, Journal of vascular surgery, 64(3) (3), 737 - 45, English, International magazine

  Scientific journal


• Early and late outcomes of repaired acute DeBakey type I aortic dissection after graft replacement.

  Atsushi Omura, Shunsuke Miyahara, Katsuhiro Yamanaka, Toshihito Sakamoto, Masamichi Matsumori, Kenji Okada, Yutaka Okita

  Feb. 2016, The Journal of thoracic and cardiovascular surgery, 151(2) (2), 341 - 8, English, International magazine

  Scientific journal


• My Struggles in Writing Paper

  OKADA Kenji

  The Shinshu Medical Society, 2016, THE SHINSHU MEDICAL JOURNAL, 64(3) (3), 101 - 102, Japanese


• 当院ICUにおける植え込み型補助人工心臓HeartMate II植込術後管理導入プロセスの報告

  大津 義徳, 清水 彩里, 三田 篤義, 今村 浩, 山田 真理, 金子 香代, 塩原 まゆみ, 道永 祐希, 瀬戸 達一郎, 岡田 健次

  (一社)日本集中治療医学会, Jan. 2016, 日本集中治療医学会雑誌, 23(Suppl.) (Suppl.), 492 - 492, Japanese


• A cure with successful staged treatment of aortoesophageal fistula.

  Akiko Tanaka, Toshihito Sakamoto, Masamichi Matsumori, Tatsuya Imanishi, Tetsu Nakamura, Kenji Okada, Yutaka Okita

  Aortoesophageal fistula is a fatal disease which needs immediate control of bleeding and infection. We report a case of aortoesophageal fistula successfully treated with extra-anatomical bypass and complete resection of infected aorta and esophagus following endovascular repair. He was discharged after reconstruction of esophagus and recurrence of infection has not been observed for the past 5 years.

  Jan. 2016, General thoracic and cardiovascular surgery, 64(1) (1), 28 - 30, English, Domestic magazine

  Scientific journal


• Mid-Term Results of Valve-Sparing Aortic Root Replacement in Patients With Expanded Indications.

  Shunsuke Miyahara, Takashi Matsueda, Naoto Izawa, Katsuhiro Yamanaka, Toshihito Sakamoto, Yoshikatsu Nomura, Naoto Morimoto, Takeshi Inoue, Masamichi Matsumori, Kenji Okada, Yutaka Okita

  Sep. 2015, The Annals of thoracic surgery, 100(3) (3), 845 - 51, English, International magazine

  Scientific journal


• Pseudoaneurysm fistulated into the right atrium after double valve replacement.

  Hiromu Kehara, Tamaki Takano, Kazunori Komatsu, Takamitsu Terasaki, Kenji Okada

  We discuss a rare case of an ascending aorta pseudoaneurysm fistulating into the right atrium following prior aortic and mitral valve replacement. Transthoracic echocardiography and computed tomography revealed a pseudoaneurysm of the ascending aorta attached to the right atrium with fistulous communication. The pseudoaneurysm arose from the center of the former aortotomy. Emergency remedian sternotomy was performed without aneurysmal injury and with exposure of the left femoral artery and femoral vein. Aneurysmal resection and ascending aorta repair were performed without complication. Exposing peripheral vessels, and initiating cardiopulmonary bypass only after reentry, might be effective in resternotomy to approach ascending aorta pseudoaneurysms.

  Aug. 2015, The heart surgery forum, 18(4) (4), E143-5, English, International magazine

  Scientific journal


• Clinical outcomes of combined aortic root reimplantation technique and total arch replacement.

  Hitoshi Minami, Shunsuke Miyahara, Kenji Okada, Masamichi Matsumori, Hiroya Kano, Takeshi Inoue, Toshihito Sakamoto, Yutaka Okita

  Jul. 2015, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 48(1) (1), 152 - 7, English, International magazine

  Scientific journal


• Aortic arch aneurysm in a patient with cold agglutinin disease.

  Shunsuke Miyahara, Hiroya Kano, Kenji Okada, Yutaka Okita

  May 2015, Interactive cardiovascular and thoracic surgery, 20(5) (5), 687 - 687, English, International magazine

  Scientific journal


• B型大動脈解離に対する治療戦略 遠隔成績と問題点 心臓血管 B型解離に対する治療戦略

  松森 正術, 辻本 貴紀, 山本 真由子, 池野 友基, 後竹 康子, 松枝 崇, 井澤 直人, 山里 隆浩, 山中 勝弘, 宮原 俊介, 野村 佳克, 坂本 敏仁, 森本 直人, 井上 武, 岡田 健次, 大北 裕

  (一社)日本外科学会, Apr. 2015, 日本外科学会定期学術集会抄録集, 115回, SY - 7, Japanese


• 心臓血管 TEVAR後open conversionの治療戦略と成績

  池野 友基, 宮原 俊介, 辻本 貴紀, 山本 真由子, 後竹 康子, 松枝 崇, 井澤 直人, 山里 隆浩, 山中 勝弘, 坂本 敏仁, 野村 佳克, 森本 直人, 井上 武, 松森 正術, 岡田 健次, 大北 裕

  (一社)日本外科学会, Apr. 2015, 日本外科学会定期学術集会抄録集, 115回, PLS - 4, Japanese


• Aortic root replacement with a valve-sparing technique for quadricuspid aortic valve.

  Katsuhiro Yamanaka, Kenji Okada, Yutaka Okita

  Apr. 2015, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 47(4) (4), 741 - 3, English, International magazine

  Scientific journal


• Aggressive multiple surgical interventions to pulmonary artery sarcoma.

  Akiko Tanaka, Tomonori Shirasaka, Kenji Okada, Yutaka Okita

  Feb. 2015, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 47(2) (2), 384 - 5, English, International magazine

  Scientific journal


• 再手術に学ぶ初回手術の注意点 特に急性解離術後、中枢再手術症例の検討

  松森 正術, 辻本 貴紀, 山本 真由子, 池野 友基, 後竹 康子, 松枝 崇, 山里 隆浩, 井澤 直人, 山中 勝弘, 宮原 俊介, 野村 佳克, 坂本 敏仁, 森本 直人, 岡田 健次, 大北 裕

  (NPO)日本心臓血管外科学会, Jan. 2015, 日本心臓血管外科学会雑誌, 44(Suppl.) (Suppl.), 159 - 159, Japanese


• 高度石灰化を有する僧帽弁弁輪部に対する僧帽弁置換術

  松枝 崇, 辻本 貴紀, 池野 友基, 後竹 康子, 山里 隆浩, 伊澤 直人, 山中 勝弘, 宮原 俊介, 野村 佳克, 坂本 敏仁, 森本 直人, 井上 武, 松森 正術, 岡田 健次, 大北 裕

  (NPO)日本心臓血管外科学会, Jan. 2015, 日本心臓血管外科学会雑誌, 44(Suppl.) (Suppl.), 242 - 242, Japanese


• 再開胸による胸腹部大動脈手術の問題点

  森本 直人, 辻本 貴紀, 山本 真由子, 池野 友基, 後竹 康子, 山里 隆浩, 松枝 崇, 井澤 直人, 山中 勝弘, 宮原 俊介, 野村 佳克, 坂本 敏仁, 松森 正術, 岡田 健次, 大北 裕

  (NPO)日本心臓血管外科学会, Jan. 2015, 日本心臓血管外科学会雑誌, 44(Suppl.) (Suppl.), 286 - 286, Japanese


• 大動脈炎症候群に伴う大動脈基部病変に対する外科治療の遠隔期成績の検討

  宮原 俊介, 辻本 貴紀, 池野 友基, 後竹 康子, 松枝 崇, 山里 隆浩, 井澤 直人, 山中 勝弘, 坂本 敏仁, 野村 佳克, 森本 直人, 井上 武, 松森 正術, 岡田 健次, 大北 裕

  (NPO)日本心臓血管外科学会, Jan. 2015, 日本心臓血管外科学会雑誌, 44(Suppl.) (Suppl.), 294 - 294, Japanese


• 大動脈食道瘻手術症例に対する病理学的検討

  山里 隆浩, 辻本 貴紀, 山本 真由子, 池野 友基, 後竹 康子, 松枝 崇, 井澤 直人, 山中 勝弘, 宮原 俊介, 野村 佳克, 坂本 敏仁, 森本 直人, 松森 正術, 岡田 健次, 大北 裕

  (NPO)日本心臓血管外科学会, Jan. 2015, 日本心臓血管外科学会雑誌, 44(Suppl.) (Suppl.), 322 - 322, Japanese


• 当院における大動脈手術術後急性膵炎に関する検討

  井澤 直人, 松森 正術, 辻本 貴紀, 山本 真由子, 池野 友基, 後竹 康子, 松枝 崇, 山里 隆浩, 山中 勝弘, 宮原 俊介, 野村 佳克, 坂本 敏仁, 森本 直人, 岡田 健次, 大北 裕

  (NPO)日本心臓血管外科学会, Jan. 2015, 日本心臓血管外科学会雑誌, 44(Suppl.) (Suppl.), 386 - 386, Japanese


• 僧帽弁閉鎖不全症に合併する三尖弁閉鎖不全症による遠隔期心不全に関する検討

  坂本 敏仁, 辻本 貴紀, 池野 友基, 山里 隆浩, 後竹 康子, 松枝 崇, 井澤 直人, 宮原 俊介, 山中 勝弘, 野村 佳克, 森本 直人, 井上 武, 松森 正術, 岡田 健次, 大北 裕

  (NPO)日本心臓血管外科学会, Jan. 2015, 日本心臓血管外科学会雑誌, 44(Suppl.) (Suppl.), 441 - 441, Japanese


• A-5. 急性肺動脈血栓塞栓症に対する外科的肺動脈内血栓摘除術の検討

  中井 秀和, 松枝 崇, 宮原 俊介, 山中 勝弘, 井澤 直人, 坂本 敏仁, 野村 佳克, 井上 武, 松森 正樹, 岡田 健次, 大北 裕

  公益財団法人 日本心臓財団, 2015, 心臓, 47(7) (7), 871 - 871, Japanese


• Prediction of reversibility of intestinal mucosal damage after ischemia-reperfusion injury by plasma intestinal fatty acid-binding protein levels in pigs.

  Kano H, Okada K, Morimoto K, Bao W, Fukase K, Ito A, Okita Y

  2015, perfusion, 30(8) (8), 617 - 625

  [Refereed]


• 縦隔炎・胸骨骨髄炎における陰圧閉鎖療法の実際 (特集 陰圧閉鎖療法の理論と実際)

  榊原 俊介, 寺師 浩人, 岡田 健次

  Jan. 2015, Pepars, (97) (97), 64-71


• New indicator of postoperative delayed awakening after total aortic arch replacement.

  Tomonori Shirasaka, Kenji Okada, Hiroya Kano, Masamichi Matsumori, Takeshi Inoue, Yutaka Okita

  Jan. 2015, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 47(1) (1), 101 - 5, English, International magazine

  Scientific journal


• Influences of chronic obstructive pulmonary disease on outcomes of total arch replacement.

  Shunsuke Miyahara, Hidekazu Nakai, Naoto Izawa, Katsuhiro Yamanaka, Toshihito Sakamoto, Yoshikatsu Nomura, Takeshi Inoue, Masamichi Matsumori, Kenji Okada, Yutaka Okita

  Jan. 2015, The Annals of thoracic surgery, 99(1) (1), 72 - 8, English, International magazine

  Scientific journal


• Surgical strategy for aorta-related infection†.

  Katsuhiro Yamanaka, Atsushi Omura, Yoshikatsu Nomura, Shunsuke Miyahara, Tomonori Shirasaka, Toshihihito Sakamoto, Takeshi Inoue, Masamichi Matsumori, Hitoshi Minami, Kenji Okada, Yutaka Okita

  Dec. 2014, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 46(6) (6), 974 - 80, English, International magazine

  Scientific journal


• Strategies for the treatment of aorto-oesophageal fistula.

  Yutaka Okita, Katsuhiro Yamanaka, Kenji Okada, Masamichi Matsumori, Takeshi Inoue, Keigo Fukase, Toshihito Sakamoto, Shunsuke Miyahara, Tomonori Shirasaka, Naoto Izawa, Taimi Ohara, Yoshikatsu Nomura, Hidekazu Nakai, Yasuko Gotake, Hiroya Kano

  Nov. 2014, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 46(5) (5), 894 - 900, English, International magazine

  Scientific journal


• In situ total aortic arch replacement for infected distal aortic arch aneurysms with penetrating atherosclerotic ulcer.

  Kenji Okada, Katsuhiro Yamanaka, Toshihito Sakamoto, Takeshi Inoue, Masamichi Matsumori, Fumi Kawakami, Yutaka Okita

  Nov. 2014, The Journal of thoracic and cardiovascular surgery, 148(5) (5), 2096 - 100, English, International magazine

  Scientific journal


• Efficacy of nafamostat mesilate as anticoagulation during cardiopulmonary bypass for early surgery in patients with active infective endocarditis complicated by stroke.

  Toshihito Sakamoto, Hiroya Kano, Shunsuke Miyahara, Takeshi Inoue, Naoto Izawa, Yasuko Gotake, Masamichi Matsumori, Kenji Okada, Yutaka Okita

  Nov. 2014, The Journal of heart valve disease, 23(6) (6), 744 - 51, English, International magazine

  Scientific journal


• Controlled release of ascorbic acid from gelatin hydrogel attenuates abdominal aortic aneurysm formation in rat experimental abdominal aortic aneurysm model.

  Akiko Tanaka, Tomomi Hasegawa, Keisuke Morimoto, Wulan Bao, Jie Yu, Yutaka Okita, Yasuhiko Tabata, Kenji Okada

  Sep. 2014, Journal of vascular surgery, 60(3) (3), 749 - 58, English, International magazine

  [Refereed]

  Scientific journal


• Controlled release of ascorbic acid from gelatin hydrogel attenuates abdominal aortic aneurysm formation in rat experimental abdominal aortic aneurysm model

  Akiko Tanaka, Tomomi Hasegawa, Keisuke Morimoto, Wulan Bao, Jie Yu, Yutaka Okita, Yasuhiko Tabata, Kenji Okada

  Sep. 2014, JOURNAL OF VASCULAR SURGERY, 60(3) (3), 749 - 758, English

  Scientific journal


• Balloon pulmonary angioplasty: an additional treatment option to improve the prognosis of patients with chronic thromboembolic pulmonary hypertension.

  Yu Taniguchi, Kazuya Miyagawa, Kazuhiko Nakayama, Hiroto Kinutani, Toshiro Shinke, Kenji Okada, Yutaka Okita, Ken-ich Hirata, Noriaki Emoto

  Aug. 2014, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 10(4) (4), 518 - 25, English, International magazine

  Scientific journal


• Early patency rate and fate of reattached intercostal arteries after repair of thoracoabdominal aortic aneurysms

  Atsushi Omura, Katsuhiro Yamanaka, Shunsuke Miyahara, Toshihito Sakamoto, Takeshi Inoue, Kenji Okada, Yutaka Okita

  Jun. 2014, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 147(6) (6), 1861 - 1867, English

  Scientific journal


• Early patency rate and fate of reattached intercostal arteries after repair of thoracoabdominal aortic aneurysms.

  Atsushi Omura, Katsuhiro Yamanaka, Shunsuke Miyahara, Toshihito Sakamoto, Takeshi Inoue, Kenji Okada, Yutaka Okita

  Jun. 2014, The Journal of thoracic and cardiovascular surgery, 147(6) (6), 1861 - 7, English, International magazine

  [Refereed]

  Scientific journal


• Total arch replacement via antero-lateral thoracotomy with partial sternotomy in patients with a tracheostoma: report of two cases

  Shunsuke Miyahara, Takeshi Inoue, Hitoshi Minami, Kenji Okada, Yutaka Okita

  May 2014, SURGERY TODAY, 44(5) (5), 972 - 975, English

  Scientific journal


• Total arch replacement via antero-lateral thoracotomy with partial sternotomy in patients with a tracheostoma: report of two cases.

  Shunsuke Miyahara, Takeshi Inoue, Hitoshi Minami, Kenji Okada, Yutaka Okita

  May 2014, Surgery today, 44(5) (5), 972 - 5, English, Domestic magazine

  [Refereed]

  Scientific journal


• Orally administered dipeptidyl peptidase-4 inhibitor (alogliptin) prevents abdominal aortic aneurysm formation through an antioxidant effect in rats

  Wulan Bao, Keisuke Morimoto, Tomomi Hasegawa, Naoto Sasaki, Tomoya Yamashita, Kenichi Hirata, Yutaka Okita, Kenji Okada

  Apr. 2014, JOURNAL OF VASCULAR SURGERY, 59(4) (4), 1098 - 1108, English

  Scientific journal


• Orally administered dipeptidyl peptidase-4 inhibitor (alogliptin) prevents abdominal aortic aneurysm formation through an antioxidant effect in rats.

  Wulan Bao, Keisuke Morimoto, Tomomi Hasegawa, Naoto Sasaki, Tomoya Yamashita, Kenichi Hirata, Yutaka Okita, Kenji Okada

  Apr. 2014, Journal of vascular surgery, 59(4) (4), 1098 - 108, English, International magazine

  [Refereed]

  Scientific journal


• Subsequent shunt closure after targeted medical therapy can be an effective strategy for secundum atrial septal defect with severe pulmonary arterial hypertension: two case reports : strategy for ASD with severe PAH.

  Yu Taniguchi, Noriaki Emoto, Kazuya Miyagawa, Kazuhiko Nakayama, Hiroto Kinutani, Hidekazu Tanaka, Toshiro Shinke, Kenji Okada, Yutaka Okita, Ken-ich Hirata

  Mar. 2014, Heart and vessels, 29(2) (2), 282 - 5, English, Domestic magazine

  [Refereed]

  Scientific journal


• Subsequent shunt closure after targeted medical therapy can be an effective strategy for secundum atrial septal defect with severe pulmonary arterial hypertension: two case reports

  Yu Taniguchi, Noriaki Emoto, Kazuya Miyagawa, Kazuhiko Nakayama, Hiroto Kinutani, Hidekazu Tanaka, Toshiro Shinke, Kenji Okada, Yutaka Okita, Ken-ich Hirata

  Mar. 2014, HEART AND VESSELS, 29(2) (2), 282 - 285, English

  Scientific journal


• Outcome of elective total aortic arch replacement in patients with non-dialysis-dependent renal insufficiency stratified by estimated glomerular filtration rate

  Kenji Okada, Atsushi Omura, Hiroya Kano, Hidekazu Nakai, Shunsuke Miyahara, Hitoshi Minami, Yutaka Okita

  Mar. 2014, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 147(3) (3), 966 - +, English

  Scientific journal


• Outcome of elective total aortic arch replacement in patients with non-dialysis-dependent renal insufficiency stratified by estimated glomerular filtration rate.

  Kenji Okada, Atsushi Omura, Hiroya Kano, Hidekazu Nakai, Shunsuke Miyahara, Hitoshi Minami, Yutaka Okita

  Mar. 2014, The Journal of thoracic and cardiovascular surgery, 147(3) (3), 966 - 972, English, International magazine

  [Refereed]

  Scientific journal


• Mitral valve replacement versus annuloplasty for treating severe functional mitral regurgitation.

  Kazunori Yoshida, Kenji Okada, Shunsuke Miyahara, Atsushi Omura, Takeshi Inoue, Hitoshi Minami, Yutaka Okita

  OBJECTIVES: To improve the clinical outcome of patients with severe functional mitral regurgitation (FMR) associated with ischemic cardiomyopathy (ICM), we compared the therapeutic efficacy of mitral annuloplasty (MAP) with that of mitral valve replacement (MVR). METHODS: In a retrospective observation 63 consecutive patients underwent mitral valve surgery for severe ICM-FMR from November 1999 to March 2012. All patients had severe FMR (regurgitant volume >60 ml/beat) with Carpentier type I and type IIIb disease. Mean RV was 74.0 ± 35.0 ml/beat and coaptation depth was 12.7 ± 3.0 mm. Twenty-six patients (41.3 %) were treated by MVR with sparing of the subvalvular apparatus and 37 (58.7 %) by MAP. RESULTS: Total in-hospital mortality was 6.3 %. Kaplan-Meier survival estimates at 1 and 5 years were 84.2 and 78.6 % in the MVR group and 82.6 and 71.6 % in the MAP group, with no significant difference between groups (p = 0.758). Freedom from major adverse cardiac and cerebrovascular events (MACCE) at 5 years was 66.9 % for patients treated by MVR and 64.1 % for those treated by MAP (p = 0.866). At the last follow-up visit, >grade II MR had recurred in 4 annuloplasty patients (10.8 %). In multivariate analysis, independent predictors of increased late death and MACCE were significantly associated with residual pulmonary hypertension (late death: odds ratio = 25.0, p = 0.0009; MACCE: odds ratio = 31.3, p = 0.0001). CONCLUSIONS: Mitral valve replacement with sparing of the subvalvular apparatus is a safe and effective surgical alternative for patients with severe FMR.

  Jan. 2014, General thoracic and cardiovascular surgery, 62(1) (1), 38 - 47, English, Domestic magazine

  Scientific journal


• Mid-Term Results of Aortic Root Reimplantation in Patients with Severe Aortic Regurgitation

  Shunsuke Miyahara, Katsuhiro Yamanaka, Toshihito Sakamoto, Yoshikatsu Nomura, Takeshi Inoue, Masamichi Matsumori, Kenji Okada, Yutaka Okita

  2014, CARDIOLOGY, 128(2) (2), 127 - 127, English


• Efficacy of Nafamostat Mesilate as Anticoagulation During Cardiopulmonary Bypass on Early Surgery in Patients with Active Infective Endocarditis Complicated by Stroke

  Yutaka Okita, Toshihito Sakamoto, Kenji Okada, Hiroya Kano, Katsuhiro Yamanaka, Shunsuke Miyahara, Takeshi Inoue, Naoto Izawa, Yasuko Gotake, Masamichi Matsumori

  2014, CARDIOLOGY, 128(2) (2), 173 - 173, English


• Balloon Pulmonary Angioplasty Improves Clinical Status and Hemodynamics in Patients With Non-operable Chronic Thromboembolic Pulmonary Hypertension in Comparison to Pulmonary Endarterectomy in Operable Patients

  Kazuya Mivagawa, Noriaki Fmoto, Yu Taniguachi, Hiroto Kinutani, Kazuhiko Nakayama, Toshiro Shinke, Ken-ichi Hirata, Kenji Okada, Yutaka Okita

  Nov. 2013, CIRCULATION, 128(22) (22), -, English


• The Model for End-Stage Liver Disease (MELD) Predicts Early and Late Outcomes of Cardiovascular Operations in Patients With Liver Cirrhosis

  Naoto Morimoto, Kenji Okada, Yutaka Okita

  Nov. 2013, ANNALS OF THORACIC SURGERY, 96(5) (5), 1672 - 1678, English

  Scientific journal


• The model for end-stage liver disease (MELD) predicts early and late outcomes of cardiovascular operations in patients with liver cirrhosis.

  Naoto Morimoto, Kenji Okada, Yutaka Okita

  Nov. 2013, The Annals of thoracic surgery, 96(5) (5), 1672 - 8, English, International magazine

  [Refereed]

  Scientific journal


• [Total aortic arch replacement;our current surgical management and outcomes].

  Atsushi Omura, Kenji Okada, Hiroya Kano, Toshihito Sakamoto, Takeshi Inoue, Masamichi Matsumori, Yutaka Okita

  OBJECTIVE: We report our current surgical management and early and late outcomes of total arch replacement. METHOD: From October 1999 to December 2012, 372 consecutive patients (mean age 71.8±12.0) underwent total arch replacement through a median sternotomy at our institute. Mean Japan score (predicted 30 day mortality) was 8.0±9.2( median 4.4). Our current surgical approach included the following:(1) meticulous selection of arterial cannulation site and type of arterial cannula;(2) circulatory arrest at tympanic temperature (below 23 °C) and rectal temperature (below 30 °C);(3) antegrade selective cerebral perfusion and cerebral monitoring of regional cerebral saturation;(4) early rewarming just after distal anastomosis;(5)maintaining fluid balance below 1,000 ml during cardiopulmonary bypass. RESULTS: Overall 30 day and in-hospital mortality was 1.6%( 6/372) and 3.8%( 14/372), and was 1.0%(3/308)and 2.6% (8/308) in elective cases. Permanent neurologic deficit occurred in 2.2%(8/372) of patients. The mean follow up period were46±39months(range2~165 months). Survival at 5 and 10 years after surgery was 75.8±2.8% and 66.0±3.8%, respectively. During follow up period, there was only one total arch replacement related problem (proximal anastomosis aneurysm). Freedom from additional aortic surgery and aortic related event at 5 and 10 years was 90.8 ±2.2% and 86.1±3.4%,respectively. CONCLUSION: Our current approach for total aortic arch replacement was associated with low hospital mortality and morbidities and with favorable long-term outcome.

  Oct. 2013, Kyobu geka. The Japanese journal of thoracic surgery, 66(11) (11), 969 - 75, Japanese, Domestic magazine

  Scientific journal


• 慢性血栓塞栓性肺高血圧症に対する肺動脈カテーテル治療と血栓内膜摘除術の比較

  谷口 悠, Shinke Toshiro, 絹谷 洋人, 宮川 一也, 中山 和彦, 大竹 寛雅, 江本 憲昭, Hirata Ken-ichi, 岡田 健次, 大北 裕

  Sep. 2013, 日本心臓病学会誌, 8(Suppl.I) (Suppl.I), 389, Japanese

  Research society


• 大動脈四尖弁に対する自己弁温存基部置換術

  山中 勝弘, 大村 篤史, 白坂 知識, 宮原 俊介, 野村 佳克, 坂本 敏仁, 井上 武, 南 一司, Okada Kenji, Okita Yutaka

  Sep. 2013, 日本心臓血管外科学会雑誌, 42(5号) (5号), 412 - 415, Japanese

  [Refereed]

  Scientific journal


• Vegetation attached to the elephant trunk

  Akiko Tanaka, Toshihito Sakamoto, Kenji Okada, Yutaka Okita

  Sep. 2013, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 44(3) (3), 565 - 566, English


• Vegetation attached to the elephant trunk.

  Akiko Tanaka, Toshihito Sakamoto, Kenji Okada, Yutaka Okita

  Sep. 2013, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 44(3) (3), 565 - 6, English, International magazine

  [Refereed]

  Scientific journal


• Successful surgical treatment of aortoesophageal fistula after emergency thoracic endovascular aortic repair: Aggressive debridement including esophageal resection and extended aortic replacement

  Hiroshi Munakata, Katsuhiro Yamanaka, Kenji Okada, Yutaka Okita

  Jul. 2013, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 146(1) (1), 235 - 237, English


• Successful surgical treatment of aortoesophageal fistula after emergency thoracic endovascular aortic repair: aggressive débridement including esophageal resection and extended aortic replacement.

  Hiroshi Munakata, Katsuhiro Yamanaka, Kenji Okada, Yutaka Okita

  Jul. 2013, The Journal of thoracic and cardiovascular surgery, 146(1) (1), 235 - 7, English, International magazine

  [Refereed]

  Scientific journal


• Impact of Postoperative Cusp Configuration on Mid-Term Durability after Aortic Root Reimplantation

  Miyahara, Shunsuke, Omura, Atsushi, Sakamoto, Toshihito, Nomura, Yoshikatsu, Inoue, Takeshi, Minami, Hitoshi, Okada, Kenji, Okita, Yutaka

  Jul. 2013, JOURNAL OF HEART VALVE DISEASE, 22(4) (4), 509-516


• Impact of postoperative cusp configuration on midterm durability after aortic root reimplantation.

  Shunsuke Miyahara, Atsushi Omura, Toshihito Sakamoto, Yoshikatsu Nomura, Takeshi Inoue, Hitoshi Minami, Kenji Okada, Yutaka Okita

  BACKGROUND AND AIM OF THE STUDY: The study aim was to examine the echocardiographic features associated with recurrent aortic regurgitation (AR) after valve-preserving aortic root reconstruction surgery. METHODS: Echocardiographic data from 86 patients who underwent aortic root replacement with or without cusp repair were retrospectively reviewed. An analysis was conducted of the height difference between the level of the ventriculoaortic junction (VAJ) and the central free margin of the cusp, defined as the effective height (EH), and the length from the aortic annulus to the edge of the body of Arantius, defined as the geometric height (GH), in addition to root dimensions (diameter of VAJ, sinus of Valsalva, and sinotubular junction). RESULTS: All patients presented with < or = mild AR at discharge. After a median follow up duration of 46.4 months, the development of moderate AR or greater was observed in 14 patients. The overall actuarial freedom from moderate AR or greater, and freedom from reoperation at three and five years were 86.2 +/- 4.4% and 81.8 +/- 5.2%, and 94.0 +/- 3.0% and 91.8 +/- 3.6%, respectively. The postoperative EH (7.47 +/- 3.3 mm in > mild AR group, versus 8.81 +/- 2.1 mm in < or = mild AR group, p = 0.049), the incidence of postoperative eccentric jet (57.1% in > mild AR group versus 12.5% in < or = mild AR group, p = 0.0005) and cusp billowing (78.6% in > mild AR group versus 20.8% in < or = mild AR group, p < 0.0001) were significantly correlated with > mild AR in the follow up. There was also correlation between postoperative EH and the severity of recurrent AR at follow up (p = -0.33, p = 0.0019). CONCLUSION: Objective information on cusp configuration, such as EH, should play an important role in stabilizing the outcome of valve-sparing surgery.

  Jul. 2013, The Journal of heart valve disease, 22(4) (4), 509 - 16, English, International magazine

  [Refereed]

  Scientific journal


• Early and Midterm Outcomes of Open Surgical Correction After Thoracic Endovascular Aortic Repair

  Shunsuke Miyahara, Yoshikatsu Nomura, Tomonori Shirasaka, Hideto Taketoshi, Katsuhiro Yamanaka, Atsushi Omura, Toshihito Sakamoto, Takeshi Inoue, Hitoshi Minami, Kenji Okada, Yutaka Okita

  May 2013, ANNALS OF THORACIC SURGERY, 95(5) (5), 1584 - 1590, English

  Scientific journal


• Early and midterm outcomes of open surgical correction after thoracic endovascular aortic repair.

  Shunsuke Miyahara, Yoshikatsu Nomura, Tomonori Shirasaka, Hideto Taketoshi, Katsuhiro Yamanaka, Atsushi Omura, Toshihito Sakamoto, Takeshi Inoue, Hitoshi Minami, Kenji Okada, Yutaka Okita

  May 2013, The Annals of thoracic surgery, 95(5) (5), 1584 - 90, English, International magazine

  [Refereed]

  Scientific journal


• EVAR後type 2 endoleakに対する治療

  野村 佳克, 後竹 康子, 竹歳 秀人, 宮原 俊介, 白坂 知識, 坂本 敏仁, 大村 篤史, 井上 武, 南 一司, 岡田 健次, 宮本 直和, 山口 雅人, 井戸口 孝二, Sugimoto Koji, 大北 裕

  Apr. 2013, 日本血管外科学会雑誌, 22(2号) (2号), 455, Japanese

  Research society


• Effect of atherothrombotic aorta on outcomes of total aortic arch replacement.

  Kenji Okada, Atsushi Omura, Hiroya Kano, Takeshi Inoue, Takanori Oka, Hitoshi Minami, Yutaka Okita

  Apr. 2013, The Journal of thoracic and cardiovascular surgery, 145(4) (4), 984 - 991, English, International magazine

  [Refereed]

  Scientific journal


• Mitral valve repair in active infective endocarditis with cerebral infarction.

  Kenji Okada, Tomonori Shirasaka, Hiroya Kano, Yutaka Okita

  Apr. 2013, Asian cardiovascular & thoracic annals, 21(2) (2), 215 - 7, English, International magazine

  [Refereed]

  Scientific journal


• Effect of atherothrombotic aorta on outcomes of total aortic arch replacement

  Kenji Okada, Atsushi Omura, Hiroya Kano, Takeshi Inoue, Takanori Oka, Hitoshi Minami, Yutaka Okita

  Apr. 2013, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 145(4) (4), 984 - +, English

  Scientific journal


• 大動脈瘤に対するステントグラフト内挿術の適応拡大における問題点 IFU外症例に対するステントグラフト内挿術の治療成績

  Sugimoto Koji, 井戸口 孝二, 山口 雅人, 野村 佳克, 大北 裕

  (一社)日本外科学会, Mar. 2013, 日本外科学会雑誌, 114(臨増2) (臨増2), 737 - 737, Japanese

  Research society


• Total arch replacement using selective antegrade cerebral perfusion as the neuroprotection strategy.

  Yutaka Okita, Kenji Okada, Atsushi Omura, Hiroya Kano, Hitoshi Minami, Takeshi Inoue, Toshihito Sakamoto, Shunsuke Miyahara, Tomonori Shirasaka, Katsuhiro Yamanaka, Taimi Ohara, Yoshikatsu Nomura, Hidekazu Nakai

  BACKGROUND: Optimal neuro-protection strategy in aortic arch surgery is a controversial issue. The present study reported surgical outcomes of total arch replacement using selective antegrade cerebral perfusion (SACP). METHODS: From January 2002 to December 2012, 438 consecutive patients (mean age 69.1±13.4 years) underwent total arch replacement using SACP through a median sternotomy. Acute aortic dissection was present in 86 patients (18.3; 80 type A, 6 type B) and shaggy aorta in 36 (8.2%). Emergent/urgent surgery was required in 144 (32.9%). Our current approach included: (I) meticulous selection of arterial cannulation site and type of arterial cannula; (II) selective antegrade cerebral perfusion; (III) maintenance of minimal tympanic temperature between 20 and 23 °C; (IV) early re-warming after distal anastomosis; and (V) maintaining fluid balance below 1,000 mL during cardiopulmonary bypass. A woven Dacron four branch graft was used in all patients. RESULTS: Overall hospital mortality was 4.6% (20/438). Hospital mortality was 9.7% (14/144) in urgent/emergent surgery and 2.0% (6/294) in elective cases. Permanent neurological deficit occurred in 5.3% (23/438) of patients. Prolonged ventilation was necessary in 58 patients (13.2%). Multivariate analysis demonstrated that risk factors for hospital mortality were octogenarian (OR 4.45, P=0.03), brain malperfusion (OR 23.52, P=0.002) and cardiopulmonary bypass time (OR 1.07, P=0.04). The follow-up was completed in 97.9% with mean follow up of 2.3±2.3 years. Survival at 5 and 10 years after surgery was 79.6±3.3% and 71.2±5.0% respectively. In the acute type A dissection group, 10-year survival was 96.8±2.9%, while in the elective non-dissection group 5- and 10-year survival were 81.4±7.2% and 77.0±5.9% respectively. CONCLUSIONS: Our current approach for total aortic arch replacement utilizing SACP was associated with low hospital mortality and morbidities leading to favorable long-term outcome.

  Mar. 2013, Annals of cardiothoracic surgery, 2(2) (2), 169 - 74, English, International magazine

  [Refereed]

  Scientific journal


• Total arch replacement using antegrade cerebral perfusion

  Yutaka Okita, Kenji Okada, Atsushi Omura, Hiroya Kano, Hitoshi Minami, Takeshi Inoue, Shunsuke Miyahara

  Mar. 2013, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 145(3) (3), S63 - S71, English

  Scientific journal


• Total arch replacement using antegrade cerebral perfusion.

  Yutaka Okita, Kenji Okada, Atsushi Omura, Hiroya Kano, Hitoshi Minami, Takeshi Inoue, Shunsuke Miyahara

  Mar. 2013, The Journal of thoracic and cardiovascular surgery, 145(3 Suppl) (3 Suppl), S63-71 - S71, English, International magazine

  [Refereed]

  Scientific journal


• Surgical techniques of total arch replacement using selective antegrade cerebral perfusion.

  Yutaka Okita, Kenji Okada, Atsushi Omura, Hiroya Kano, Hitoshi Minami, Takeshi Inoue, Toshihito Sakamoto, Shunsuke Miyahara, Tomonori Shirasaka, Katsuhiro Yamanaka, Taimi Ohara, Yoshikatsu Nomura, Hidekazu Nakai

  Mar. 2013, Annals of cardiothoracic surgery, 2(2) (2), 222 - 8, English, International magazine

  [Refereed]

  Scientific journal


• Results of cardiac surgery in advanced liver cirrhosis.

  Naoto Morimoto, Kenji Okada, Yutaka Okita

  Feb. 2013, General thoracic and cardiovascular surgery, 61(2) (2), 79 - 83, English, Domestic magazine

  [Refereed]

  Scientific journal


• Extended replacement of the thoracic aorta

  Yutaka Hino, Kenji Okada, Takanori Oka, Takeshi Inoue, Akiko Tanaka, Atsushi Omura, Hiroya Kano, Yutaka Okita

  Jan. 2013, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 43(1) (1), 176 - 181, English

  Scientific journal


• Extended replacement of the thoracic aorta.

  Yutaka Hino, Kenji Okada, Takanori Oka, Takeshi Inoue, Akiko Tanaka, Atsushi Omura, Hiroya Kano, Yutaka Okita

  Jan. 2013, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 43(1) (1), 176 - 81, English, International magazine

  [Refereed]

  Scientific journal


• Direct visualization of the aortic cusp from the left ventricle during aortic root reimplantation

  Yutaka Okita, Takanori Oka, Shunsuke Miyahara, Kenji Okada

  Oct. 2012, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 144(4) (4), 981 - 982, English


• Direct visualization of the aortic cusp from the left ventricle during aortic root reimplantation.

  Yutaka Okita, Takanori Oka, Shunsuke Miyahara, Kenji Okada

  Oct. 2012, The Journal of thoracic and cardiovascular surgery, 144(4) (4), 981 - 2, English, International magazine

  [Refereed]

  Scientific journal


• Open reconstruction of thoracoabdominal aortic aneurysms.

  Yutaka Okita, Atsushi Omura, Katsuaki Yamanaka, Takeshi Inoue, Hiroya Kano, Rei Tanioka, Hitoshi Minami, Toshihito Sakamoto, Shunsuke Miyahara, Tomonori Shirasaka, Taimi Ohara, Hidekazu Nakai, Kenji Okada

  Technical details of our strategy for reconstructing the thoracoabdominal aorta are presented. Between October 1999 and June 2012, 152 patients underwent surgery for thoracoabdominal aortic aneurysms (Crawford classification type I =21, type II =43, type III =73, type IV =15). Mean age was 64.6±13.9 years. Sixty-three (41.4%) patients had aortic dissection, including acute type B dissection in 2 (1.2%) and ruptured aneurysms in 17 (11.2%). Eight (5.3%) patients had mycotic aneurysms, and 3 (2.0%) had aortitis. Emergent or urgent surgery was performed in 25 (16.4%) patients. Preoperative computed tomography (CT) scan or magnetic resonance (MR) angiography detected the Adamkiewicz artery in 103 (67.8%) patients. Cerebrospinal fluid drainage (CSFD) was performed in 115 (75.7%) patients and intraoperative motor evoked potentials were recorded in 97 (63.8%). One hundred and seven (70.4%) patients had reconstruction of the intercostal arteries from T7 to L2, 35 of which were reconstructed with the aortic patch technique and 72 with branched grafts. The mean number of reconstructed intercostal arteries was 3.1±2.5 pairs. Mild hypothermic partial cardiopulmonary bypass at 32-34 °C was used in 105 (69.1%) patients, left heart bypass was used in 4 (2.6%), and deep hypothermic cardiopulmonary bypass below 20 °C was used in 42 (27.6%). Thirty-day mortality was 9 (5.9%), and hospital mortality was 20 (13.2%). Independent risk factors for hospital mortality were emergency surgery (OR 13.4, P=0.003) and aortic cross clamping over 2 hours (OR 5.7, P=0.04). Postoperative spinal cord ischemia occurred in 16 (10.5%, 8 patients with paraplegia and 8 with paraparesis). Risk factors for developing spinal cord ischemic complications were prior surgery involving either the descending thoracic or the abdominal aorta (OR 3.75, P=0.05), diabetes mellitus (OR 5.49, P=0.03), and post-bypass hypotension <80 mmHg (OR 1.06, P=0.03). Postoperative survival at 5 years was 83.6±4.5%; 5-year survival was 47.5±8.6% in patients with spinal cord ischemia and 88.9±10.4% in those without spinal cord ischemia.

  Sep. 2012, Annals of cardiothoracic surgery, 1(3) (3), 373 - 80, English, International magazine

  Scientific journal


• Early and Late Results of Graft Replacement for Dissecting Aneurysm of Thoracoabdominal Aorta in Patients With Marfan Syndrome

  Atsushi Omura, Akiko Tanaka, Shunsuke Miyahara, Toshihito Sakamoto, Yoshikatsu Nomura, Takeshi Inoue, Takanori Oka, Hitoshi Minami, Kenji Okada, Yutaka Okita, John H. Calhoon

  Sep. 2012, ANNALS OF THORACIC SURGERY, 94(3) (3), 759 - 765, English

  Scientific journal


• Early and late results of graft replacement for dissecting aneurysm of thoracoabdominal aorta in patients with Marfan syndrome.

  Atsushi Omura, Akiko Tanaka, Shunsuke Miyahara, Toshihito Sakamoto, Yoshikatsu Nomura, Takeshi Inoue, Takanori Oka, Hitoshi Minami, Kenji Okada, Yutaka Okita

  Sep. 2012, The Annals of thoracic surgery, 94(3) (3), 759 - 65, English, International magazine

  [Refereed]

  Scientific journal


• Aggressive Surgical Treatment of Acute Pulmonary Embolism With Circulatory Collapse

  Hiroaki Takahashi, Kenji Okada, Masamichi Matsumori, Hiroya Kano, Atsushi Kitagawa, Yutaka Okita

  Sep. 2012, ANNALS OF THORACIC SURGERY, 94(3) (3), 785 - 791, English

  Scientific journal


• Aggressive surgical treatment of acute pulmonary embolism with circulatory collapse.

  Hiroaki Takahashi, Kenji Okada, Masamichi Matsumori, Hiroya Kano, Atsushi Kitagawa, Yutaka Okita

  Sep. 2012, The Annals of thoracic surgery, 94(3) (3), 785 - 91, English, International magazine

  [Refereed]

  Scientific journal


• Short and Midterm Outcomes of Elective Total Aortic Arch Replacement Combined With Coronary Artery Bypass Grafting

  Kenji Okada, Atsushi Omura, Hiroya Kano, Taimi Ohara, Tomonori Shirasaka, Katsuhiro Yamanaka, Shunsuke Miyahara, Toshihito Sakamoto, Akiko Tanaka, Takeshi Inoue, Takanori Oka, Hitoshi Minami, Yutaka Okita

  Aug. 2012, ANNALS OF THORACIC SURGERY, 94(2) (2), 530 - 536, English

  Scientific journal


• Short and midterm outcomes of elective total aortic arch replacement combined with coronary artery bypass grafting.

  Kenji Okada, Atsushi Omura, Hiroya Kano, Taimi Ohara, Tomonori Shirasaka, Katsuhiro Yamanaka, Shunsuke Miyahara, Toshihito Sakamoto, Akiko Tanaka, Takeshi Inoue, Takanori Oka, Hitoshi Minami, Yutaka Okita

  Aug. 2012, The Annals of thoracic surgery, 94(2) (2), 530 - 6, English, International magazine

  [Refereed]

  Scientific journal


• 三尖弁位の感染性心内膜炎に合併した疣贅塞栓の1例

  田中 亜紀子, 坂本 敏仁, Okada Kenji, 大北 裕

  Japan Heart Foundation, Jul. 2012, 心臓, 44(7号) (7号), 872 - 873, Japanese

  [Refereed]

  Scientific journal


• Recent advancements of total aortic arch replacement

  Kenji Okada, Atsushi Omura, Hiroya Kano, Toshihito Sakamoto, Akiko Tanaka, Takeshi Inoue, Yutaka Okita

  Jul. 2012, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 144(1) (1), 139 - 145, English

  Scientific journal


• Recent advancements of total aortic arch replacement.

  Kenji Okada, Atsushi Omura, Hiroya Kano, Toshihito Sakamoto, Akiko Tanaka, Takeshi Inoue, Yutaka Okita

  Jul. 2012, The Journal of thoracic and cardiovascular surgery, 144(1) (1), 139 - 45, English, International magazine

  [Refereed]

  Scientific journal


• Free-radical scavenger edaravone inhibits both formation and development of abdominal aortic aneurysm in rats

  Keisuke Morimoto, Tomomi Hasegawa, Akiko Tanaka, Bao Wulan, Jie Yu, Naoto Morimoto, Yutaka Okita, Kenji Okada

  Jun. 2012, JOURNAL OF VASCULAR SURGERY, 55(6) (6), 1749 - 1758, English

  Scientific journal


• Free-radical scavenger edaravone inhibits both formation and development of abdominal aortic aneurysm in rats.

  Keisuke Morimoto, Tomomi Hasegawa, Akiko Tanaka, Bao Wulan, Jie Yu, Naoto Morimoto, Yutaka Okita, Kenji Okada

  Jun. 2012, Journal of vascular surgery, 55(6) (6), 1749 - 58, English, International magazine

  [Refereed]

  Scientific journal


• 腹部大動脈瘤ステントグラフト内挿術の治療成績 IFU内vs IFU外

  Nomura Yoshikatsu, Yamaguchi Masato, Miyahara Shunsuke, Shirasaka Tomonori, Sakamoto Toshihito, Omura Atsushi, Tanaka Akiko, Inoue Takeshi, Oka Takanori, Minami Hitoshi, Sugimoto Koji, Okada Kenji, Okita Yutaka

  (NPO)日本血管外科学会, May 2012, 日本血管外科学会雑誌, 21(3) (3), 400 - 400, Japanese

  Research society


• 内臓動脈瘤に対する治療方針の検討

  Sakamoto Toshihito, Shirasaka Tomonori, Miyahara Shunsuke, Omura Atsushi, Nomura Yoshikatsu, Tanaka Akiko, Inoue Takeshi, Oka Takanori, Minami Hitoshi, Okada Kenji, Okita Yutaka, Yamaguchi Masato, Sugimoto Koji

  (NPO)日本血管外科学会, May 2012, 日本血管外科学会雑誌, 21(3) (3), 424 - 424, Japanese

  Research society


• 総腸骨動脈瘤に対するステントグラフト内挿術の治療成績

  Nomura Yoshikatsu, Miyahara Shunsuke, Shirasaka Tomonori, Sakamoto Toshihito, Omura Atsushi, Tanaka Akiko, Inoue Takeshi, Oka Takanori, Minami Hitoshi, Yamaguchi Masato, Sugimoto Koji, Okada Kenji, Okita Yutaka

  (NPO)日本血管外科学会, May 2012, 日本血管外科学会雑誌, 21(3) (3), 469 - 470, Japanese

  Research society


• Gianturco Z stent graftによるTEVARの遠隔期type III endoleakの治療経験

  Nomura Yoshikatsu, Shirasaka Tomonori, Miyahara Shunsuke, Omura Atsushi, Sakamoto Toshihito, Tanaka Akiko, Oka Takanori, Minami Hitoshi, Okada Kenji, Okada Takuya, Idoguchi Koji, Yamaguchi Masato, Sugimoto Koji, Okita Yutaka

  (NPO)日本血管外科学会, Apr. 2012, 日本血管外科学会雑誌, 21(2) (2), 162 - 162, Japanese

  Research society


• 腹部大動脈瘤の治療成績 EVAR vs Open Surgery

  Nomura Yoshikatsu, Shirasaka Tomonori, Miyahara Shunsuke, Sakamoto Toshihito, Omura Atsushi, Tanaka Akiko, Inoue Takeshi, Oka Takanori, Okada Kenji, Okita Yutaka, Yamaguchi Masato, Sugimoto Koji

  (NPO)日本心臓血管外科学会, Mar. 2012, 日本心臓血管外科学会雑誌, 41(Suppl.) (Suppl.), 444 - 444, Japanese

  Research society


• Impact of left ventricular afterload on longitudinal dyssynchrony in patients with severe aortic stenosis and preserved ejection fraction.

  Kohei Yamawaki, Hidekazu Tanaka, Kensuke Matsumoto, Mana Hiraishi, Tatsuya Miyoshi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Kazuko Norisada, Yuko Fukuda, Kazuhiro Tatsumi, Tetsuari Onishi, Kenji Okada, Yutaka Okita, Hiroya Kawai, Ken-ichi Hirata

  2012, Circulation journal : official journal of the Japanese Circulation Society, 76(3) (3), 744 - 51, English, Domestic magazine

  Scientific journal


• 狭小大動脈に発症した外傷性断裂に対すTEVAR施行例

  Shirasaka Tomonori, Miyahara Shunsuke, Nomura Yoshikatsu, Omura Atsushi, Sakamoto Toshihito, Tanaka Akiko, Munakata Hiroshi, Inoue Takeshi, Oka Takanori, Minami Hitoshi, Kitagawa Atsushi, Okada Kenji, Okita Yutaka, Okada Takuya, Idoguchi Koji, Yamaguchi Masato, Sugimoto Koji

  (NPO)日本血管外科学会, Dec. 2011, 日本血管外科学会雑誌, 20(7) (7), 1011 - 1011, Japanese

  Research society


• Lack of neurologic improvement after aortic repair for acute type A aortic dissection complicated by cerebral malperfusion: Predictors and association with survival

  Naoto Morimoto, Kenji Okada, Yutaka Okita

  Dec. 2011, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 142(6) (6), 1540 - 1544, English

  Scientific journal


• Lack of neurologic improvement after aortic repair for acute type A aortic dissection complicated by cerebral malperfusion: predictors and association with survival.

  Naoto Morimoto, Kenji Okada, Yutaka Okita

  Dec. 2011, The Journal of thoracic and cardiovascular surgery, 142(6) (6), 1540 - 4, English, International magazine

  [Refereed]

  Scientific journal


• Aortic Regurgitation After Valve-Sparing Aortic Root Replacement: Modes of Failure

  Takanori Oka, Yutaka Okita, Masamichi Matsumori, Kenji Okada, Hitoshi Minami, Hiroshi Munakata, Takeshi Inoue, Akiko Tanaka, Toshihito Sakamoto, Atsushi Omura, Takuo Nomura

  Nov. 2011, ANNALS OF THORACIC SURGERY, 92(5) (5), 1639 - U504, English

  Scientific journal


• Aortic regurgitation after valve-sparing aortic root replacement: modes of failure.

  Takanori Oka, Yutaka Okita, Masamichi Matsumori, Kenji Okada, Hitoshi Minami, Hiroshi Munakata, Takeshi Inoue, Akiko Tanaka, Toshihito Sakamoto, Atsushi Omura, Takuo Nomura

  Nov. 2011, The Annals of thoracic surgery, 92(5) (5), 1639 - 44, English, International magazine

  Scientific journal


• [Repair versus replacement of mitral valve for treating severe functional mitral regurgitation].

  Kazunori Yoshida, Takeshi Inoue, Hiroshi Munakata, Hitoshi Minami, Takanori Oka, Kenji Okada, Yutaka Okita

  BACKGROUND: The purpose of this study is to compare mitral valve replacement (MVR) to anuloplasty (MAP) in patients with severe functional mitral regurgitation (FMR). METHODS: Data of 43 patients with significant chronic FMR who underwent mitral valve operations from November 1999 through May 2011 were retrospectively analyzed. This reference group included patients who underwent MVR (n = 18) and MAP (undersized restrictive annuloplasty, n = 25). The mitral valve is replaced sparing the continuity between mitral valve and subvalvular apparatus. All patients had severe FMR, and 71.4% had New York Heart Association (NYHA) III or IV symptoms of heart failure, and 20% had preoperative intraaortic balloon pumping (IABP) insertion. The MVR group had significantly higher risk patients with complex jet and advanced coaptation depth (13.3 +/- 2.1 versus 11.1 +/- 2.3 mm, p = 0.04). RESULTS: Hospital mortality was 9.3%. No statistical difference was found between the 2 groups in term of intraoperative data. Kaplan-Meier survival estimates at 1, 5 years was 82.6, 72.3% in MVR group, and 77.8, 69.7% in MAP group (p = 0.98). Freedom from Cardiac-related event at 5 years was 62.7% for MVR compared to 56.8 % for MAP (p = 0.75). At the last follow-up, recurrence of MR II or greater was present in 4 (14.8%) patients in the MAP group and only one patient required re-operation because of worsening heart failure. In multivariable analysis, independent predictor of increased cardiac-related event was associated with residual pulmonary hypertension (HR, 3.0: p = 0.021). CONCLUSIONS: In high-risk patients with severe FMR. MVR seems to be a reasonable option.

  Oct. 2011, Kyobu geka. The Japanese journal of thoracic surgery, 64(11) (11), 963 - 7, Japanese, Domestic magazine

  Scientific journal


• Antioxidant properties of pioglitazone limit nicotinamide adenine dinucleotide phosphate hydrogen oxidase and augment superoxide dismutase activity in cardiac allotransplantation.

  Tomomi Hasegawa, Kenji Okada, Yutaka Okita, David J Pinsky

  Oct. 2011, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 30(10) (10), 1186 - 96, English, International magazine

  [Refereed]

  Scientific journal


• Patch annulo-aortoplasty in an adult patient with congenital supravalvular aortic stenosis and a small aortic annulus.

  Naoto Morimoto, Keisuke Morimoto, Yoshihisa Morimoto, Akiko Tanaka, Toshihito Sakamoto, Kenji Okada, Yutaka Okita

  A 39-year-old woman with familial homozygous hypercholesterolemia had supravalvular and valvular aortic stenosis. Modified Nick's procedure and aortic valve replacement was performed to relieve both the supravalvular and annular stenoses. At surgery, the ascending aorta was found to be narrowing at the level of the sinotubular junction, which was compatible with congenital supravalvular aortic stenosis. Histological examination of the aortic cusps showed sclerotic change due to hypercholesterolemia. These findings indicated that familial homozygous hypercholesterolemia caused valvular aortic stenosis and exacerbated congenital supravalvular aortic stenosis.

  Aug. 2011, General thoracic and cardiovascular surgery, 59(8) (8), 569 - 71, English, Domestic magazine

  Scientific journal


• Off-pump coronary artery bypass grafting in an octogenarian with situs inversus and dextrocardia: report of a case.

  Hiroaki Takahashi, Kenji Okada, Masamichi Matsumori, Yutaka Okita

  Aug. 2011, Surgery today, 41(8) (8), 1130 - 2, English, Domestic magazine

  Scientific journal


• Successful surgical management for aortic and mitral stenosis in homozygous familial hypercholesterolemia: a case report.

  Naoto Morimoto, Kenji Okada, Yutaka Okita

  Jul. 2011, General thoracic and cardiovascular surgery, 59(7) (7), 491 - 4, English, Domestic magazine

  [Refereed]

  Scientific journal


• 腹部大動脈瘤に対するEVAR後の機種別治療成績

  Nomura Yoshikatsu, Miyahara Shunsuke, Omura Atsushi, Sakamoto Toshihito, Tanaka Akiko, Fujita Yasuyuki, Munakata Hiroshi, Inoue Takeshi, Oka Takanori, Minami Hitoshi, Kitagawa Atsushi, Okada Kenji, Okita Yutaka, Yamaguchi Masato, Sugimoto Koji

  (一社)日本外科学会, May 2011, 日本外科学会雑誌, 112(臨増1-2) (臨増1-2), 833 - 833, Japanese

  Research society


• TEVARにおける脊髄虚血症例の検討

  Kitagawa Atsushi, Okita Yutaka, Okada Kenji, Minami Hitoshi, Oka Takanori, Inoue Takeshi, Munakata Hiroshi, Omura Atsushi, Nomura Yoshikatsu, Yamaguchi Masato, Sugimoto Koji, Sugimura Kazuro

  (一社)日本外科学会, May 2011, 日本外科学会雑誌, 112(臨増1-2) (臨増1-2), 832 - 832, Japanese

  Research society


• 当院における浅大腿動脈病変に対する治療成績

  Nomura Yoshikatsu, Sakamoto Toshihito, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Inoue Takeshi, Oka Takanori, Minami Hitoshi, Kitagawa Atsushi, Okada Kenji, Okita Yutaka, Yamaguchi Masato, Sugimoto Koji

  (NPO)日本血管外科学会, Apr. 2011, 日本血管外科学会雑誌, 20(2) (2), 350 - 350, Japanese

  Research society


• 大動脈気管支瘻、食道瘻、感染性胸部大動脈瘤に対するTEVAR

  Kitagawa Atsushi, Nomura Yoshikatsu, Omura Atsushi, Munakata Hiroshi, Inoue Takeshi, Oka Takanori, Minami Hitoshi, Yamaguchi Masato, Okada Kenji, Sugimoto Koji, Sugimura Kazuro, Okita Yutaka

  (NPO)日本血管外科学会, Apr. 2011, 日本血管外科学会雑誌, 20(2) (2), 304 - 304, Japanese

  Research society


• TEVARの急性期、遠隔期イベント発生に及ぼす危険因子の検討

  Kitagawa Atsushi, Yamaguchi Masato, Sugimoto Koji, Nomura Yoshikatsu, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Inoue Takeshi, Oka Takanori, Minami Hitoshi, Okada Kenji, Sugimura Kazuro, Okita Yutaka

  (NPO)日本心臓血管外科学会, Jan. 2011, 日本心臓血管外科学会雑誌, 40(Suppl.) (Suppl.), 261 - 261, Japanese

  Research society


• Ability of optical coherence tomography to visualize the entry port of spontaneous coronary artery dissection.

  Masayuki Nakagawa, Junya Shite, Toshiro Shinke, Hiromasa Otake, Kenji Okada, Yutaka Okita, Ken-ichi Hirata

  2011, Circulation journal : official journal of the Japanese Circulation Society, 75(10) (10), 2505 - 7, English, Domestic magazine

  Scientific journal


• Preoperative Carotid Reperfusion in Type A Aortic Dissection: How Safe Is it? Reply

  Hiroshi Munakata, Kenji Okada, Hiroya Kano, So Izumi, Yutaka Hino, Masamichi Matsumori, Yutaka Okita

  Nov. 2010, ANNALS OF THORACIC SURGERY, 90(6) (6), 2089 - 2089, English


• Activation of transglutaminase type 2 for aortic wall protection in a rat abdominal aortic aneurysm formation.

  Takashi Munezane, Tomomi Hasegawa, Suritala, Akiko Tanaka, Kenji Okada, Yutaka Okita

  Oct. 2010, Journal of vascular surgery, 52(4) (4), 967 - 74, English, International magazine

  Scientific journal


• Left atrial extension of metastatic lung tumor via pulmonary vein: report on the first case of Ewing sarcoma.

  Yohei Funakoshi, Toru Mukohara, Tomoko Kataoka, Hideo Tomioka, Naoko Chayahara, Yutaka Fujiwara, Naomi Kiyota, Tomonori Shirasaka, Takanori Oka, Kenji Okada, Yutaka Okita, Shigeo Hara, Tomoo Itoh, Soichi Fumita, Kazuhiko Nakagawa, Hironobu Minami

  Extension of metastatic lung tumors into the left atrium via pulmonary veins is rare. Here, we report the first case of Ewing sarcoma exhibiting such extension. A 31-year-old man with pulmonary metastasis from Ewing sarcoma presented with a mass in the left lung, extending to the left atrium through the left inferior pulmonary vein. As the patient was considered to be at risk of tumor embolism, the mass was excised surgically.

  Sep. 2010, Rare tumors, 2(3) (3), e53, English, International magazine


• Aortic root replacement through right anterolateral thoracotomy.

  Hideki Takahashi, Kenji Okada, Masamichi Matsumori, Yutaka Okita

  Sep. 2010, Interactive cardiovascular and thoracic surgery, 11(3) (3), 345 - 7, English, International magazine

  Scientific journal


• Pioglitazone preserves vein graft integrity in a rat aortic interposition model.

  Zhi Chen, Tomomi Hasegawa, Akiko Tanaka, Yutaka Okita, Kenji Okada

  Aug. 2010, The Journal of thoracic and cardiovascular surgery, 140(2) (2), 408 - 416, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Pioglitazone preserves vein graft integrity in a rat aortic interposition model

  Zhi Chen, Tomomi Hasegawa, Akiko Tanaka, Yutaka Okita, Kenji Okada

  Aug. 2010, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 140(2) (2), 408 - e1, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Excessively high systemic blood pressure in the early phase of reperfusion exacerbates early-onset paraplegia in rabbit aortic surgery.

  Bishow Pokhrel, Tomomi Hasegawa, So Izumi, Atsushi Ohmura, Hiroshi Munakata, Yutaka Okita, Kenji Okada

  Aug. 2010, The Journal of thoracic and cardiovascular surgery, 140(2) (2), 400 - 7, English, International magazine

  Scientific journal


• Excessively high systemic blood pressure in the early phase of reperfusion exacerbates early-onset paraplegia in rabbit aortic surgery

  Bishow Pokhrel, Tomomi Hasegawa, So Izumi, Atsushi Ohmura, Hiroshi Munakata, Yutaka Okita, Kenji Okada

  Aug. 2010, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 140(2) (2), 400 - 407, English

  [Refereed]

  Scientific journal


• Aneurysm expansion caused by an intercostal type II endoleak after thoracic endovascular aortic repair for secondary elephant trunk graft fixation

  Atsushi Kitagawa, Hitoshi Matsuda, Kenji Okada, Yutaka Okita

  Jun. 2010, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 139(6) (6), E128 - E130, English

  Scientific journal


• Aneurysm expansion caused by an intercostal type II endoleak after thoracic endovascular aortic repair for secondary elephant trunk graft fixation.

  Atsushi Kitagawa, Hitoshi Matsuda, Kenji Okada, Yutaka Okita

  Jun. 2010, The Journal of thoracic and cardiovascular surgery, 139(6) (6), e128-30 - E130, English, International magazine

  [Refereed]

  Scientific journal


• Controlled low-flow reperfusion after warm brain ischemia reduces reperfusion injury in canine model

  Hiroshi Munakata, Kenji Okada, Tomomi Hasegawa, Yutaka Hino, Hiroya Kano, Masamichi Matsumori, Yutaka Okita

  May 2010, PERFUSION-UK, 25(3) (3), 159 - 168, English

  Scientific journal


• Controlled low-flow reperfusion after warm brain ischemia reduces reperfusion injury in canine model.

  Hiroshi Munakata, Kenji Okada, Tomomi Hasegawa, Yutaka Hino, Hiroya Kano, Masamichi Matsumori, Yutaka Okita

  May 2010, Perfusion, 25(3) (3), 159 - 68, English, International magazine

  [Refereed]

  Scientific journal


• Augmentation of systemic blood pressure during spinal cord ischemia to prevent postoperative paraplegia after aortic surgery in a rabbit model

  So Izumi, Kenji Okada, Tomomi Hasegawa, Atsushi Omura, Hiroshi Munakata, Masamichi Matsumori, Yutaka Okita

  May 2010, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 139(5) (5), 1261 - 1268, English

  Scientific journal


• Augmentation of systemic blood pressure during spinal cord ischemia to prevent postoperative paraplegia after aortic surgery in a rabbit model.

  So Izumi, Kenji Okada, Tomomi Hasegawa, Atsushi Omura, Hiroshi Munakata, Masamichi Matsumori, Yutaka Okita

  May 2010, The Journal of thoracic and cardiovascular surgery, 139(5) (5), 1261 - 8, English, International magazine

  [Refereed]

  Scientific journal


• TEVARの適応と限界 Shaggy aortaはcontraindicationか?

  Kitagawa Atsushi, Okita Yutaka, Okada Kenji, Hasegawa Tomoki, Matsumori Masamichi, Minami Hitoshi, Munakata Hiroshi, Yamaguchi Masato, Sugimoto Koji, Sugimura Kazuro

  (一社)日本外科学会, Mar. 2010, 日本外科学会雑誌, 111(臨増2) (臨増2), 532 - 532, Japanese

  Research society


• 当院における企業製EVARの早期中期成績

  Kitagawa Atsushi, Okita Yutaka, Okada Kenji, Hasegawa Tomoki, Minami Hitoshi, Matsumori Masamichi, Munakata Hiroshi, Oka Takanori, Nomura Yoshikatsu, Omura Atsushi, Yamaguchi Masato, Sugimoto Koji, Sugimura Kazuro

  (NPO)日本心臓血管外科学会, Jan. 2010, 日本心臓血管外科学会雑誌, 39(Suppl.) (Suppl.), 373 - 373, Japanese

  Research society


• A Case of Two-stage Entire Aortic Replacement for a Case of Megaaorta Syndrome

  IZUMI So, MUNAKATA Hiroshi, MATSUMORI Masamichi, KITAGAWA Atsushi, OKADA Kenji, OKITA Yutaka

  A 69-year-old woman with back pain was admitted to our hospital 3 months previously due to a type-A acute aortic dissection with megaaorta syndrome. The aortic aneurysm extended from the ascending aorta to the bilateral iliac arteries. Initially, a total arch replacement with elephant trunk installation and an abdominal aortic aneurysm repair were performed simultaneously. One month after the first stage operation, the thoracoabdominal aortic aneurysm was repaired, applying distal perfusion, mild hypothermia, CSF drainage, segmental aortic clamping, reconstruction of intercostal and lumbar arteries, and edaravone for spinal cord protection. Transcranial motor evoked potentials (tc-MEP) were monitored during the operation. Although tc-MEPs disappeared due to spinal cord ischemia during aortic cross-clamping, the amplitude of tc-MEP recovered after hypertension treatment and a quick reattachment of the intercostal arteries. The 8th, 10th and 11th intercostal arteries and the 1st lumbar artery were reconstructed. This patient was discharged 20 days postoperatively without any neurologic deficit.

  JAPANESE SOCIETY FOR VASCULAR SURGERY, Dec. 2009, Jpn. J. Vasc. Surg., 18(7) (7), 695 - 700, Japanese


• A novel rat model of abdominal aortic aneurysm using a combination of intraluminal elastase infusion and extraluminal calcium chloride exposure.

  Akiko Tanaka, Tomomi Hasegawa, Zhi Chen, Yutaka Okita, Kenji Okada

  Dec. 2009, Journal of vascular surgery, 50(6) (6), 1423 - 32, English, International magazine

  Scientific journal


• 腹部大動脈瘤に対するEVAR 日本における適応と限界 Zenith AAAステントグラフト適応基準からの検討

  Kitagawa Atsushi, Okada Kenji

  (NPO)日本血管外科学会, Oct. 2009, 日本血管外科学会雑誌, 18(6) (6), 595 - 602, Japanese

  [Refereed]

  Scientific journal


• 【大動脈基部置換術】 自己弁温存 自己弁温存大動脈基部置換術における弁形成の有効性

  Okada Kenji

  Oct. 2009, 胸部外科, 62巻, 11号, pp. 971-977, Japanese

  [Refereed]

  Scientific journal


• Newly developed tissue-engineered material for reconstruction of vascular wall without cell seeding.

  Hiroaki Takahashi, Takenori Yokota, Eiichiro Uchimura, Shigeru Miyagawa, Takeyoshi Ota, Kei Torikai, Atsuhiro Saito, Koichiro Hirakawa, Katsukiyo Kitabayashi, Kenji Okada, Yoshiki Sawa, Yutaka Okita

  Oct. 2009, The Annals of thoracic surgery, 88(4) (4), 1269 - 76, English, International magazine

  Scientific journal


• Newly Developed Tissue-Engineered Material for Reconstruction of Vascular Wall Without Cell Seeding

  Hiroaki Takahashi, Takenori Yokota, Eiichiro Uchimura, Shigeru Miyagawa, Takeyoshi Ota, Kei Torikai, Atsuhiro Saito, Koichiro Hirakawa, Katsukiyo Kitabayashi, Kenji Okada, Yoshiki Sawa, Yutaka Okita

  Oct. 2009, ANNALS OF THORACIC SURGERY, 88(4) (4), 1269 - 1276, English

  [Refereed]

  Scientific journal


• Adjustment of Sinotubular Junction for Aortic Insufficiency Secondary to Ascending Aortic Aneurysm

  Naoto Morimoto, Masamichi Matsumori, Akiko Tanaka, Hiroshi Munakata, Kenji Okada, Yutaka Okita

  Oct. 2009, ANNALS OF THORACIC SURGERY, 88(4) (4), 1238 - 1243, English

  Scientific journal


• Adjustment of sinotubular junction for aortic insufficiency secondary to ascending aortic aneurysm.

  Naoto Morimoto, Masamichi Matsumori, Akiko Tanaka, Hiroshi Munakata, Kenji Okada, Yutaka Okita

  Oct. 2009, The Annals of thoracic surgery, 88(4) (4), 1238 - 43, English, International magazine

  [Refereed]

  Scientific journal


• Renoprotective immunosuppression by pioglitazone with low-dose cyclosporine in rat heart transplantation

  Yosuke Tanaka, Tomomi Hasegawa, Zhi Chen, Yutaka Okita, Kenji Okada

  Sep. 2009, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 138(3) (3), 744 - 751, English

  Scientific journal


• Renoprotective immunosuppression by pioglitazone with low-dose cyclosporine in rat heart transplantation.

  Yosuke Tanaka, Tomomi Hasegawa, Zhi Chen, Yutaka Okita, Kenji Okada

  Sep. 2009, The Journal of thoracic and cardiovascular surgery, 138(3) (3), 744 - 51, English, International magazine

  [Refereed]

  Scientific journal


• Leukoaraiosis and hippocampal atrophy predict neurologic outcome in patients who undergo total aortic arch replacement.

  Naoto Morimoto, Kenji Okada, Kensuke Uotani, Fumio Kanda, Yutaka Okita

  Aug. 2009, The Annals of thoracic surgery, 88(2) (2), 476 - 81, English, International magazine

  Scientific journal


• Leukoaraiosis and Hippocampal Atrophy Predict Neurologic Outcome in Patients Who Undergo Total Aortic Arch Replacement

  Naoto Morimoto, Kenji Okada, Kensuke Uotani, Fumio Kanda, Yutaka Okita

  Aug. 2009, ANNALS OF THORACIC SURGERY, 88(2) (2), 476 - 481, English

  [Refereed]

  Scientific journal


• Clinical significance of anastomotic leak in ascending aortic replacement for acute aortic dissection.

  Hiroshi Tanaka, Kenji Okada, Yujiro Kawanishi, Masamichi Matsumori, Yutaka Okita

  Aug. 2009, Interactive cardiovascular and thoracic surgery, 9(2) (2), 209 - 12, English, International magazine

  [Refereed]

  Scientific journal


• Bioprosthetic pulmonary and tricuspid valve replacement in carcinoid heart disease from ovarian primary cancer.

  Hiroaki Takahashi, Kenji Okada, Mitsuru Asano, Masamichi Matsumori, Yoshihisa Morimoto, Yutaka Okita

  Aug. 2009, Circulation journal : official journal of the Japanese Circulation Society, 73(8) (8), 1554 - 6, English, Domestic magazine

  [Refereed]

  Scientific journal


• Aortic regurgitation and coronary malperfusion secondary to intimo-intimal intussusception into the left ventricle in acute aortic dissection.

  Naoto Morimoto, Kenji Okada, Yutaka Okita

  Jul. 2009, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 36(1) (1), 189 - 90, English, International magazine

  Scientific journal


• Aortic regurgitation and coronary malperfusion secondary to intimo-intimal intussusception into the left ventricle in acute aortic dissection

  Naoto Morimoto, Kenji Okada, Yutaka Okita

  Jul. 2009, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 36(1) (1), 189 - 190, English

  [Refereed]

  Scientific journal


• 内臓動脈瘤に対する治療方針の検討

  坂本 敏仁, 白坂 知識, 大村 篤史, 野村 拓生, 野村 佳克, 田中 亜紀子, 高橋 宏明, 宗像 宏, 松森 正術, 北川 敦士, 南 一司, 長谷川 智巳, 岡田 健次, 大北 裕, 山口 雅人

  (NPO)日本血管外科学会, Apr. 2009, 日本血管外科学会雑誌, 18(2) (2), 386 - 386, Japanese

  [Refereed]


• Controlled Earlier Reperfusion for Brain Ischemia Caused by Acute Type A Aortic Dissection

  Hiroshi Munakata, Kenji Okada, Hiroya Kano, Sou Izumi, Yutaka Hino, Masamichi Matsumori, Yutaka Okita

  Apr. 2009, ANNALS OF THORACIC SURGERY, 87(4) (4), E27 - E28, English

  Link to Kobe Univ. Repository (Kernel)


• Controlled earlier reperfusion for brain ischemia caused by acute type A aortic dissection.

  Hiroshi Munakata, Kenji Okada, Hiroya Kano, Sou Izumi, Yutaka Hino, Masamichi Matsumori, Yutaka Okita

  Apr. 2009, The Annals of thoracic surgery, 87(4) (4), e27-8 - E28, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Palliative bidirectional Glenn anastomosis for unresectable metastasis in the right ventricle from renal cell carcinoma 16 years after nephrectomy.

  Naoto Morimoto, Keisuke Morimoto, Yoshihisa Morimoto, Toshihito Sakamoto, Akiko Tanaka, Masamichi Matsumori, Kenji Okada, Yutaka Okita

  Mar. 2009, The Journal of thoracic and cardiovascular surgery, 137(3) (3), 775 - 7, English, International magazine

  Scientific journal


• Palliative bidirectional Glenn anastomosis for unresectable metastasis in the right ventricle from renal cell carcinoma 16 years after nephrectomy

  Naoto Morimoto, Keisuke Morimoto, Yoshihisa Morimoto, Toshihito Sakamoto, Akiko Tanaka, Masamichi Matsumori, Kenji Okada, Yutaka Okita

  Mar. 2009, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 137(3) (3), 775 - 777, English

  [Refereed]

  Scientific journal


• Extended replacement of aortic arch aneurysms through left posterolateral thoracotomy

  Kenji Okada, Akiko Tanaka, Hiroshi Munakata, Masamichi Matsumori, Yoshihisa Morimoto, Yoshiaki Tanaka, Tadaaki Maehara, Yutaka Okita

  Feb. 2009, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 35(2) (2), 270 - 275, English

  Scientific journal


• Extended replacement of aortic arch aneurysms through left posterolateral thoracotomy.

  Kenji Okada, Akiko Tanaka, Hiroshi Munakata, Masamichi Matsumori, Yoshihisa Morimoto, Yoshiaki Tanaka, Tadaaki Maehara, Yutaka Okita

  Feb. 2009, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 35(2) (2), 270 - 5, English, International magazine

  Scientific journal


• Surgery for Extensive Thoracic Aortic Aneurysm

  Hiroshi Munakata, Kenji Okada, Akiko Tanaka, Masamichi Matsumori, Mitsuru Asano, Yoshihisa Morimoto, Yutaka Okita

  2009, ADVANCES IN UNDERSTANDING AORTIC DISEASES, 215 - +, English

  [Refereed]

  International conference proceedings


• Expanding Indications for Valve Sparing Procedures in Aortic Root Replacement

  Yutaka Okita, Masamichi Matsumori, Kenji Okada, Yoshihisa Morimoto, Mitsuru Asano, Hiroshi Munakata, Naoto Morimoto, Hiroaki Takahashi, Akiko Tanaka

  2009, ADVANCES IN UNDERSTANDING AORTIC DISEASES, 173 - +, English

  [Refereed]

  International conference proceedings


• Surgical Strategy in Aortic Lesion for Marfan Syndrome

  Akiko Tanaka, Kenji Okada, Hiroshi Munakata, Masamichi Matsumori, Yutaka Okita

  2009, ADVANCES IN UNDERSTANDING AORTIC DISEASES, 221 - +, English

  [Refereed]

  International conference proceedings


• DNA damage sensor protein hRad9, a novel molecular target for lung cancer treatment

  Takeshi Yuki, Yoshimasa Maniwa, Takefumi Doi, Kenji Okada, Wataru Nishio, Yoshitake Hayashi, Yutaka Okita

  Nov. 2008, ONCOLOGY REPORTS, 20(5) (5), 1047 - 1052, English

  Scientific journal


• Sivelestat attenuates postoperative pulmonary dysfunction after total arch replacement under deep hypothermia.

  Naoto Morimoto, Keisuke Morimoto, Yoshihisa Morimoto, Hiroaki Takahashi, Mitsuru Asano, Masamichi Matsumori, Kenji Okada, Yutaka Okita

  Oct. 2008, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 34(4) (4), 798 - 804, English, International magazine

  Scientific journal


• Sivelestat attenuates postoperative pulmonary dysfunction after total arch replacement under deep hypothermia

  Naoto Morimoto, Keisuke Morimoto, Yoshihisa Morimoto, Hiroaki Takahashi, Mitsuru Asano, Masamichi Matsumori, Kenji Okada, Yutaka Okita

  Oct. 2008, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 34(4) (4), 798 - 804, English

  Scientific journal


• Congenital quadricuspid aortic valve associated with severe regurgitation.

  Yujiro Kawanishi, Hiroshi Tanaka, Keitaro Nakagiri, Teruo Yamashita, Kenji Okada, Yutaka Okita

  Oct. 2008, Asian cardiovascular & thoracic annals, 16(5) (5), e40-1 - e41, English, International magazine

  Scientific journal


• Sinus node dysfunction after repair of partial anomalous pulmonary venous connection.

  Hiroaki Takahashi, Yoshihiro Oshima, Masahiro Yoshida, Masahiro Yamaguchi, Kenji Okada, Yutaka Okita

  OBJECTIVES: Sinus node dysfunction is known as a major complication after repair of partial anomalous pulmonary venous connection. We retrospectively analyzed the results of the atrial wall flap technique compared with the results of patch repair or direct suturing in the intra-atrial tunnel technique. METHODS: Between 1991 and 2007, 23 patients (mean age, 6 years; range, 5 months-17 years) with partial anomalous pulmonary venous connection underwent surgical intervention. The right anomalous pulmonary veins drained to either the right atrium or superior vena cava in 8 and 15 patients, respectively. Patients were divided into 2 groups: group F (n = 14), who had repair with an atrial flap, and group N (n = 9), who had repair without an atrial flap. All patients had normal sinus rhythm preoperatively. RESULTS: No patients had signs of superior vena cava or pulmonary venous obstruction within a mean follow-up of 4.8 years. One patient in group F required pacemaker implantation. In the early postoperative period, sinus node dysfunction developed in 93% of group F and 44% of group N patients (P < .01) and was prolonged until discharge in 57% of group F and 0% of group N patients (P < .01). At the most recent clinical visit, sinus node dysfunction was identified in 50% of group F patients, whereas all patients in group N had normal sinus rhythm (P < .02). CONCLUSIONS: The atrial flap technique, which requires incision or suture crossing the crista terminalis, could cause sinus node dysfunction, whereas the intra-atrial rerouting method with a patch or direct suture maintains normal sinus node function postoperatively.

  Aug. 2008, The Journal of thoracic and cardiovascular surgery, 136(2) (2), 329 - 34, English, International magazine

  Scientific journal


• Sinus node dysfunction after repair of partial anomalous pulmonary venous connection

  Hiroaki Takahashi, Yoshihiro Oshima, Masahiro Yoshida, Masahiro Yamaguchi, Kenji Okada, Yutaka Okita

  Aug. 2008, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 136(2) (2), 329 - 334, English

  Scientific journal


• Abdominal aortic aneurysm associated with horseshoe kidney.

  Yujiro Kawanishi, Hiroshi Tanaka, Keitaro Nakagiri, Teruo Yamashita, Kenji Okada, Yutaka Okita

  The optimal approach to abdominal aortic aneurysm with horseshoe kidney is still debated. We describe a successful abdominal aortic aneurysm repair through a left retroperitoneal approach in a 77-year-old woman with a horseshoe kidney.

  Jun. 2008, Asian cardiovascular & thoracic annals, 16(3) (3), e28-9, English, International magazine

  Scientific journal


• 急性肺動脈塞栓症に対する肺動脈内血栓摘除術の遠隔期成績の検討

  Okada Kenji

  May 2008, Therapeutic Research, 29巻, 5号, pp. 754-757, Japanese

  Scientific journal


• Reverse diastolic flow in the common carotid artery in severe aortic regurgitation, causing brain ischemia.

  Naoto Morimoto, Keisuke Morimoto, Yoshihisa Morimoto, Toshihito Sakamoto, Masamichi Matsumori, Kenji Okada, Yutaka Okita

  May 2008, The Journal of thoracic and cardiovascular surgery, 135(5) (5), 1176 - 7, English, International magazine

  Scientific journal


• Reverse diastolic flow in the common carotid artery in severe aortic regurgitation, causing brain ischemia

  Naoto Morimoto, Keisuke Morimoto, Yoshihisa Morimoto, Toshihito Sakamoto, Masamichi Matsumori, Kenji Okada, Yutaka Okita

  May 2008, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 135(5) (5), 1176 - 1177, English

  Scientific journal


• Aortic root replacement for destructive aortic valve endocarditis with left ventricular-aortic discontinuity.

  Kenji Okada, Hiroshi Tanaka, Hideki Takahashi, Naoto Morimoto, Hiroshi Munakata, Mitsuru Asano, Masamichi Matsumori, Yujiro Kawanishi, Keitaro Nakagiri, Yutaka Okita

  Mar. 2008, The Annals of thoracic surgery, 85(3) (3), 940 - 5, English, International magazine

  Scientific journal


• Aortic root replacement for destructive aortic valve endocarditis with left ventricular-aortic discontinuity

  Kenji Okada, Hiroshi Tanaka, Hideki Takahashi, Naoto Morimoto, Hiroshi Munakata, Mitsuru Asano, Masamichi Matsumori, Yujiro Kawanishi, Keitaro Nakagiri, Yutaka Okita

  Mar. 2008, ANNALS OF THORACIC SURGERY, 85(3) (3), 940 - 945, English

  Scientific journal


• Acute dissection of the innominate artery: a case of report.

  Hiroshi Munakata, Kenji Okada, Hiroshi Tanaka, Teruo Yamashita, Keitaro Nakagiri, Yutaka Okita

  Mar. 2008, General thoracic and cardiovascular surgery, 56(3) (3), 131 - 3, English, Domestic magazine

  Scientific journal


• Isolated pulmonary stenosis in an elderly person: report of a case.

  Takeyoshi Ota, Kenji Okada, Mitsuru Asano, Keitaro Nakagiri, Yutaka Okita

  2008, Surgery today, 38(12) (12), 1117 - 9, English, Domestic magazine

  Scientific journal


• Three cases of newly developed paraplegia after repairing type A acute aortic dissection.

  Yujiro Kawanishi, Kenji Okada, Keitaro Nakagiri, Atsushi Kitagawa, Hiroshi Tanaka, Masamichi Matsumori, Yutaka Okita

  Nov. 2007, The Annals of thoracic surgery, 84(5) (5), 1738 - 40, English, International magazine

  Scientific journal


• Three cases of newly developed paraplegia after repairing type a acute aortic dissection

  Yujiro Kawanishi, Kenji Okada, Keitaro Nakagiri, Atsushi Kitagawa, Hiroshi Tanaka, Masamichi Matsumori, Yutaka Okita

  Nov. 2007, ANNALS OF THORACIC SURGERY, 84(5) (5), 1738 - 1740, English

  Scientific journal


• Unicuspid aortic valve mimicking quadricuspid valve.

  Takeyoshi Ota, Kenji Okada, Yoshihisa Morimoto, Yutaka Okita

  Sep. 2007, Heart and vessels, 22(5) (5), 352 - 4, English, Domestic magazine

  Scientific journal


• Influence of perioperative hemodynamics on spinal cord ischemia in thoracoabdominal aortic repair.

  Yujiro Kawanishi, Kenji Okada, Masamichi Matsumori, Hiroshi Tanaka, Teruo Yamashita, Keitaro Nakagiri, Yutaka Okita

  Aug. 2007, The Annals of thoracic surgery, 84(2) (2), 488 - 92, English, International magazine

  Scientific journal


• Influence of Perioperative Hemodynamics on spinal cord ischemia in thoracoabdominal aortic repair

  Yujiro Kawanishi, Kenji Okada, Masamichi Matsumori, Hiroshi Tanaka, Teruo Yamashita, Keitaro Nakagiri, Yutaka Okita

  Aug. 2007, ANNALS OF THORACIC SURGERY, 84(2) (2), 488 - 492, English

  Scientific journal


• Total arch replacement for aneurysm of the aortic arch: factors influencing the distal anastomosis.

  Mitsuru Asano, Kenji Okada, Keitaro Nakagiri, Hiroshi Tanaka, Yujiro Kawanishi, Masamichi Matsumori, Hiroshi Munakata, Yutaka Okita

  Jun. 2007, Interactive cardiovascular and thoracic surgery, 6(3) (3), 283 - 7, English, International magazine

  Scientific journal


• The adverse effect of back-bleeding from lumbar arteries on spinal cord pathophysiology in a rabbit model.

  Yujiro Kawanishi, Kenji Okada, Hiroshi Tanaka, Teruo Yamashita, Keitaro Nakagiri, Yutaka Okita

  Jun. 2007, The Journal of thoracic and cardiovascular surgery, 133(6) (6), 1553 - 8, English, International magazine

  Scientific journal


• The adverse effect of back-bleeding from lumbar arteries on spinal cord pathophysiology in a rabbit model

  Yujiro Kawanishi, Kenji Okada, Hiroshi Tanaka, Teruo Yamashita, Keitaro Nakagiri, Yutaka Okita

  Jun. 2007, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 133(6) (6), 1553 - 1558, English

  [Refereed]

  Scientific journal


• Reducing the posterior wall length by using a small endoventricular patch for ischemic mitral regurgitation.

  Hiroshi Tanaka, Kenji Okada, Keitaro Nakagiri, Yujiro Kawanishi, Masamichi Matsumori, Yutaka Okita

  Jun. 2007, The Journal of thoracic and cardiovascular surgery, 133(6) (6), 1633 - 5, English, International magazine

  Scientific journal


• Reducing the posterior wall length by using a small endoventricular patch for ischemic mitral regurgitation

  Hiroshi Tanaka, Kenji Okada, Keitaro Nakagiri, Yujiro Kawanishi, Masamichi Matsumori, Yutaka Okita

  Jun. 2007, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 133(6) (6), 1633 - 1635, English

  [Refereed]

  Scientific journal


• Cardiopulmonary bypass using nafamostat mesilate for patients with infective endocarditis and recent intracranial hemorrhage.

  Takeyoshi Ota, Kenji Okada, Hiroya Kano, Yutaka Okita

  Jun. 2007, Interactive cardiovascular and thoracic surgery, 6(3) (3), 270 - 3, English, International magazine

  [Refereed]

  Scientific journal


• [Tricuspid regurgitation associated with heart failure].

  Kenji Okada, Yutaka Okita

  May 2007, Nihon rinsho. Japanese journal of clinical medicine, 65 Suppl 5, 512 - 6, Japanese, Domestic magazine

  Scientific journal


• Autologous fibrin-coated small-caliber vascular prostheses improve antithrombogenicity by reducing immunologic response

  Tomomi Hasegawa, Kenji Okada, Yoshihito Takano, Yoshiaki Hiraishi, Yutaka Okita

  May 2007, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 133(5) (5), 1268 - U50, English

  Scientific journal


• Autologous fibrin-coated small-caliber vascular prostheses improve antithrombogenicity by reducing immunologic response.

  Tomomi Hasegawa, Kenji Okada, Yoshihito Takano, Yoshiaki Hiraishi, Yutaka Okita

  May 2007, The Journal of thoracic and cardiovascular surgery, 133(5) (5), 1268 - 76, English, International magazine

  [Refereed]

  Scientific journal


• Comparison of distensibility of the aortic root and cusp motion after aortic root replacement with two reimplantation techniques: Valsalva graft versus tube graft.

  Masamichi Matsumori, Hiroshi Tanaka, Yujiro Kawanishi, Tetsuari Onishi, Keitaro Nakagiri, Teruo Yamashita, Kenji Okada, Yutaka Okita

  Apr. 2007, Interactive cardiovascular and thoracic surgery, 6(2) (2), 177 - 81, English, International magazine

  [Refereed]

  Scientific journal


• Controlled release of basic fibroblast growth factor from gelatin hydrogel sheet improves structural and physiological properties of vein graft in rat

  Tomonori Haraguchi, Kenji Okada, Yasuhiko Tabata, Yoshimasa Maniwa, Yoshitake Hayashi, Yutaka Okita

  Mar. 2007, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 27(3) (3), 548 - 555, English

  Scientific journal


• Controlled release of basic fibroblast growth factor from gelatin hydrogel sheet improves structural and physiological properties of vein graft in rat.

  Tomonori Haraguchi, Kenji Okada, Yasuhiko Tabata, Yoshimasa Maniwa, Yoshitake Hayashi, Yutaka Okita

  Mar. 2007, Arteriosclerosis, thrombosis, and vascular biology, 27(3) (3), 548 - 55, English, International magazine

  Scientific journal


• Usefulness of transcranial motor evoked potentials during thoracoabdominal aortic surgery.

  Yujiro Kawanishi, Hiroshi Munakata, Masamichi Matsumori, Hiroshi Tanaka, Teruo Yamashita, Keitaro Nakagiri, Kenji Okada, Yutaka Okita

  Feb. 2007, The Annals of thoracic surgery, 83(2) (2), 456 - 61, English, International magazine

  Scientific journal


• Usefulness of transcranial motor evoked potentials during thoracoabdominal aortic surgery

  Yujiro Kawanishi, Hiroshi Munakata, Masamichi Matsumori, Hiroshi Tanaka, Teruo Yamashita, Keitaro Nakagiri, Kenji Okada, Yutaka Okita

  Feb. 2007, ANNALS OF THORACIC SURGERY, 83(2) (2), 456 - 461, English

  [Refereed]

  Scientific journal


• Aortic Root Replacement for Destructive Aortic Valve Endocarditis or Aortitis

  Okada Kenji, Tanaka Hiroshi, Morimoto Naoto, Munakata Hiroshi, Asano Mitsuru, Matsumori Masamichi, Kitagawa Atsushi, Kawanishi Yujiro, Nakagiri Keitaro, Okita Yutaka

  Destructive aortic valve endocarditis or poor controlled aortitis cause the development of left ventricular-aortic discontinuity. We reported our experience with aortic root replacement for cases of severe aortic annular destruction. Between 1999 and 2006, 9 patients with severe aortic annular destruction underwent aortic root replacement at our institute. There were 8 men and one women with a mean age of 55 years. Seven patients were in New York Heart Association functional class III. Four of 9 patients had native valve endocarditis, 4 had prosthetic valve endocarditis (previous aortic valve replacements in 2, aortic root replacements in 2) and one had active aortitis with a detached mechanical valve. Radical debridement of the infected cavity and necrotic tissue was performed in all cases, followed by reconstruction of the aortic annulus using autologous or xenogenic pericardium in 3 cases. Antibiotic-saturated fibrin glue was applied to the cavity. Aortic root replacement was achieved with a pulmonary autograft (Ross procedure) in 4 and stentless aortic root xenograft in 4. One patient who had advanced liver cirrhosis underwent aortic valve replacement with a stentless xenograft by subcoronary implantation method. No mortality was observed during hospitalization and follow-up. Reoperation within 5 years was not necessary in 66.7% of the patients. Excellent outcome can be achieved by radical exclusion of the abscess cavity and viable pulmonary autograft or stentless aortic root xenograft in patients with severe aortic annular destruction.

  The Japanese Society for Cardiovascular Surgery, 2007, J. J. C. V. S., 36(6) (6), 315 - 320, Japanese


• Double-layered collagen gel hemisphere for cell invasion assay: Successful visualization and quantification of cell invasion activity

  Masahiko Takata, Yoshimasa Maniwa, Takefumi Doi, Yugo Tanaka, Kenji Okada, Wataru Nishio, Chiho Ohbayashi, Masahiro Yoshimura, Yoshitake Hayashi, Yutaka Okita

  2007, CELL COMMUNICATION AND ADHESION, 14(4) (4), 157 - 167, English

  Scientific journal


• Reconstruction of the intercostal arteries with small-branched grafts in patients with thoracoabdominal or descending aortic aneurysms.

  Yutaka Okita, Yujiro Kawanishi, Keitaro Nakagiri, Hiroshi Tanaka, Masamichi Matsumori, Mitsuru Asano, Teruo Yamashita, Kenji Okada

  An extent II thoracoabdominal aortic aneurysm of 60 mm diameter was exposed through the left 6(th) intercostal space and retroperitoneal approach. The partial cardiopulmonary bypass was initiated through the femoral arterial and venous cannulation. A knitted Dacron graft of 22 mm with four spatially orientated branches for the abdominal viscera and five branches for the intercostal arteries was utilized. The thoracoabdominal aorta was replaced with staged segmental aortic clamping. The proximal aorta, just distal to the left subclavian artery, was completely transected and anastomosed to the graft. The descending aorta was clamped at Th 10 level. The Th 8 and 9 intercostal arteries were clamped from the outside of the aorta. After opening the aorta, the left orifice of Th 8(th) and Th 9(th) intercostal arteries were anastomosed to the side branches of the graft, respectively. Similarly, the 10(th) and 11(th) intercostal arteries were reconstructed. After clamping the infra-renal portion of the abdominal aorta, four visceral arteries were perfused using an 8 French size balloon-tipped catheter. Each artery was anastomosed to the side branch of the graft. The distal anastomosis was performed and cardiopulmonary bypass was weaned-off.

  Jan. 2007, Multimedia manual of cardiothoracic surgery : MMCTS, 2007(219) (219), mmcts.2006.002014, English, International magazine

  Scientific journal


• Surgical experience for the pulmonary artery sarcoma.

  Ayako Maruo, Yutaka Okita, Kenji Okada, Teruo Yamashita, Satoshi Tobe, Nobuhiro Tanimura

  Dec. 2006, The Annals of thoracic surgery, 82(6) (6), 2014 - 6, English, International magazine

  Scientific journal


• Surgical experience for the pulmonary artery sarcoma

  Ayako Maruo, Yutaka Okita, Kenji Okada, Teruo Yamashita, Satoshi Tobe, Nobuhiro Tanimura

  Dec. 2006, ANNALS OF THORACIC SURGERY, 82(6) (6), 2014 - 2016, English

  [Refereed]

  Scientific journal


• Perforation of the Valsalva sinus after implantation of medtronic freestyle aortic bioprosthesis

  Nobuchika Ozaki, Yutaka Hino, Yuji Hanafusa, Teruo Yamashita, Kenji Okada, Takuro Tsukube, Yutaka Okita

  Dec. 2006, ANNALS OF THORACIC SURGERY, 82(6) (6), 2282 - 2285, English

  [Refereed]

  Scientific journal


• Perforation of the Valsalva sinus after implantation of Medtronic Freestyle aortic bioprosthesis.

  Nobuchika Ozaki, Yutaka Hino, Yuji Hanafusa, Teruo Yamashita, Kenji Okada, Takuro Tsukube, Yutaka Okita

  Dec. 2006, The Annals of thoracic surgery, 82(6) (6), 2282 - 5, English, International magazine

  Scientific journal


• Feasibility of preservation of subvalvular apparatus in mitral valve replacement with the On-X mechanical valve.

  Hiroshi Tanaka, Teruo Yamshita, Kenji Okada, Keitaro Nakagiri, Yujiro Kawanishi, Yutaka Okita

  Dec. 2006, The Journal of thoracic and cardiovascular surgery, 132(6) (6), 1470 - 1, English, International magazine

  Scientific journal


• Feasibility of preservation of subvalvular apparatus in mitral valve replacement with the On-X mechanical valve

  Hiroshi Tanaka, Teruo Yamshita, Kenji Okada, Keitaro Nakagiri, Yujiro Kawanishi, Yutaka Okita

  Dec. 2006, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 132(6) (6), 1470 - 1471, English

  [Refereed]

  Scientific journal


• New assessment of platelet deposition in small caliber vascular prostheses using technetium-99m apcitide scintigraphy in rabbit model.

  Tomomi Hasegawa, Kenji Okada, Yutaka Okita

  Oct. 2006, Journal of vascular surgery, 44(4) (4), 840 - 5, English, International magazine

  Scientific journal


• Resection of malignant fibrous histiocytoma involving the thoracoabdominal aorta with staged emobolization of the intercostal arteries

  Masamichi Matsumori, Ayako Maruo, Hiroshi Tanaka, Keitaro Nakagiri, Teruo Yamashita, Kenji Okada, Yutaka Okita

  Sep. 2006, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 132(3) (3), 681 - 683, English

  Scientific journal


• Resection of malignant fibrous histiocytoma involving the thoracoabdominal aorta with staged embolization of the intercostal arteries.

  Masamichi Matsumori, Ayako Maruo, Hiroshi Tanaka, Keitaro Nakagiri, Teruo Yamashita, Kenji Okada, Yutaka Okita

  Sep. 2006, The Journal of thoracic and cardiovascular surgery, 132(3) (3), 681 - 3, English, International magazine

  [Refereed]

  Scientific journal


• Disruption of the vascular prosthesis caused by aortic calcification after replacement of the thoracoabdominal aortic aneurysm

  Hiroshi Tanaka, Kenji Okada, Teruo Yamashita, Yujiro Kawanishi, Masamiti Matsumori, Yutaka Okita

  Sep. 2006, ANNALS OF THORACIC SURGERY, 82(3) (3), 1097 - 1099, English

  Scientific journal


• Disruption of the vascular prosthesis caused by aortic calcification after replacement of the thoracoabdominal aortic aneurysm.

  Hiroshi Tanaka, Kenji Okada, Teruo Yamashita, Yujiro Kawanishi, Masamiti Matsumori, Yutaka Okita

  Sep. 2006, The Annals of thoracic surgery, 82(3) (3), 1097 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Pathologic features of cryopreserved aortic allograft implanted in the active infection.

  Akitoshi Yamada, Kenji Okada, Rei Takahashi, Yutaka Okita

  Jul. 2006, The Journal of thoracic and cardiovascular surgery, 132(1) (1), 203 - 4, English, International magazine

  Scientific journal


• Accessory mitral valve causing left ventricular outflow tract obstruction and mitral insufficiency.

  Hiroshi Tanaka, Kenji Okada, Teruo Yamshita, Keitaro Nakagiri, Masamichi Matsumori, Yutaka Okita

  Jul. 2006, The Journal of thoracic and cardiovascular surgery, 132(1) (1), 160 - 1, English, International magazine

  Scientific journal


• Surgical treatment for Kommerell's diverticulum.

  Takeyoshi Ota, Kenji Okada, Shuichiro Takanashi, Shin Yamamoto, Yutaka Okita

  Mar. 2006, The Journal of thoracic and cardiovascular surgery, 131(3) (3), 574 - 8, English, International magazine

  Scientific journal


• Indium-111-oxine-labeled platelet scintigraphic images in the assessment of thrombogenicity in small-caliber prosthetic vascular grafts

  T Hasegawa, K Okada, Y Morimoto, Y Okita

  Mar. 2006, ASAIO JOURNAL, 52(2) (2), 140 - 144, English

  Scientific journal


• His239Arg SNP of HRAD9 is associated with lung adenocarcinoma.

  Yoshimasa Maniwa, Masahiro Yoshimura, Vladimir P Bermudez, Kenji Okada, Naoki Kanomata, Chiho Ohbayashi, Yoshihiro Nishimura, Yoshitake Hayashi, Jerard Hurwitz, Yutaka Okita

  Mar. 2006, Cancer, 106(5) (5), 1117 - 22, English, International magazine

  Scientific journal


• 大動脈造影下CTによるAdamkiewicz動脈の術前評価 経静脈造影CTとの比較

  魚谷健祐, TANIGUCHI, Takanori, KAWASAKI, Ryota, TSURUSAKI, Masakatsu, FUJII, Masahiko, SUGIMURA, Kazuro, 森本直人, OKADA, Kenji, OKITA, Yutaka

  Feb. 2006, 日本医学放射線学会雑誌, 65回抄録集, pp.S288-S288, Japanese

  International conference proceedings


• A localized intimomedial defect resulted in aortic regurgitation.

  Naoto Morimoto, Yutaka Okita, Kenji Okada, Teruo Yamashita, Keitaro Nakagiri, Ayako Maruo, Yujiro Kawanishi, Masamichi Matsumori, Mitsuru Asano

  Jan. 2006, The Journal of thoracic and cardiovascular surgery, 131(1) (1), 232 - 3, English, International magazine

  Scientific journal


• Aortic valve replacement for a case of anomalous origin of the left coronary artery from posterior sinus of Valsalva with intramural aortic course

  N Morimoto, Y Okita, K Okada, T Yamashita, M Matsumori

  Dec. 2005, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 130(6) (6), 1713 - 1714, English

  Scientific journal


• Thrombin-free fibrin coating on small caliber vascular prostheses has high antithrombogenicity in rabbit model.

  Tomomi Hasegawa, Kenji Okada, Yoshihito Takano, Yoshiaki Hiraishi, Yutaka Okita

  Nov. 2005, Artificial organs, 29(11) (11), 880 - 6, English, International magazine

  Scientific journal


• Surgery for gastric cancer combined with cardiac and aortic surgery.

  Yoshihiko Tsuji, Naoto Morimoto, Hiroshi Tanaka, Kenji Okada, Hitoshi Matsuda, Takuro Tsukube, Yoshihisa Watanabe, Yutaka Okita

  Nov. 2005, Archives of surgery (Chicago, Ill. : 1960), 140(11) (11), 1109 - 14, English, International magazine

  Scientific journal


• Hybrid small-caliber vascular prosthesis for coronary artery bypass grafting: A preliminary study of plasm in-treated fibrin-coated vascular prosthesis

  T Hasegawa, K Okada, Y Takano, Y Hiraishi, Y Yoshida, Y Okita

  Nov. 2005, ASAIO JOURNAL, 51(6) (6), 725 - 729, English

  Scientific journal


• Controlled release of basic fibroblast growth factor from gelatin hydrogel sheet promotes the optimal arterilization and increases the blood flow of vein graf in rat

  T Haraguchi, K Okada, Y Tabata, Y Maniwa, Y Okita

  Oct. 2005, CIRCULATION, 112(17) (17), U358 - U358, English

  Scientific journal


• 著明な接合不全を伴う重症僧帽弁閉鎖不全症に対して僧帽弁輪形成術を施行した1例

  辰巳和宏, KAWAI, Hiroya, 片岡俊哉, 大西哲存, 田中秀和, 溝口貴裕, YOKOYAMA, Mitsuhiro, OKADA, Kenji, OKITA, Yutaka

  Jul. 2005, 超音波医学, 32巻, 4号, pp.432-432, Japanese

  International conference proceedings


• Surgical results of acute aortic dissection complicated with cerebral malperfusion.

  Hiroshi Tanaka, Kenji Okada, Teruo Yamashita, Yoshihisa Morimoto, Yujiro Kawanishi, Yutaka Okita

  Jul. 2005, The Annals of thoracic surgery, 80(1) (1), 72 - 6, English, International magazine

  Scientific journal


• Surgical treatment for rupture of left ventricular free wall after acute myocardial infarction.

  Kenji Okada, Teruo Yamashita, Masamichi Matsumori, Yutaka Hino, Yuji Hanafusa, Nobuchika Ozaki, Yoshihiko Tsuji, Yutaka Okita

  Jun. 2005, Interactive cardiovascular and thoracic surgery, 4(3) (3), 203 - 6, English, International magazine

  [Refereed]

  Scientific journal


• Controlled release of basic fibroblast growth factor from gelatin hydrogel sheet inhibits neointimal hyperplasia and improves the patency of vein graft in rat

  T Haraguchi, K Okada, Y Tabata, Y Maniwa, Y Okita

  May 2005, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 25(5) (5), E69 - E69, English

  Scientific journal


• Successful valve repair for congenital bicuspid aortic valve and degenerated prolapsed mitral valve.

  Akiko Tanaka, Kenji Okada, Masamichi Matsumori, Nobuchika Ozaki, Yutaka Okita

  Japanese Association for Thoracic Surgery, May 2005, The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi, 53(5) (5), 290 - 2, English, Domestic magazine

  Scientific journal


• Successful surgery in a patient with a rupture of descending aorta complicated by acute type A aortic dissection through left-sided thoracotomy.

  Hiroshi Tanaka, Teruo Yamashita, Kenji Okada, Yutaka Okita

  Apr. 2005, Interactive cardiovascular and thoracic surgery, 4(2) (2), 116 - 7, English, International magazine

  [Refereed]

  Scientific journal


• A case with four-channel aortic dissection.

  Yutaka Okita, Kenji Okada, Takuro Tsukube, Yosuke Tanaka

  Feb. 2005, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 27(2) (2), 348 - 50, English, International magazine

  [Refereed]

  Scientific journal


• Accumulation of hRad9 protein in the nuclei of nonsmall cell lung carcinoma cells.

  Yoshimasa Maniwa, Masahiro Yoshimura, Vladimir P Bermudez, Takeshi Yuki, Kenji Okada, Naoki Kanomata, Chiho Ohbayashi, Yoshitake Hayashi, Jerard Hurwitz, Yutaka Okita

  Jan. 2005, Cancer, 103(1) (1), 126 - 32, English, International magazine

  [Refereed]

  Scientific journal


• 肺動脈肉腫の外科治療

  HANAFUSA,Yuji, OKADA, Kenji, OZAKI,Nobuchika, YAMASHITA,Teruo, MORIMOTO,Yoshihisa, 日野裕, OKITA, Yutaka, 戸部智, 谷村信宏

  Jun. 2004, Therapeutic Research, 25巻, 6号, pp. 1159-1161, Japanese

  [Refereed]

  Scientific journal


• Long-term outcome of postoperative interferon-alpha adjuvant therapy for non-metastatic renal cell carcinoma

  GOTOH,Akinobu, SHIRAKAWA, Toshiro, Hinata Nobuyuki, WADA,Yoshitaka, HARA, Isao, FUJISAWA, Masato, KAWABATA,Gaku, OKADA,Hiroshi, Arakawa Soichi, KAMIDONO,Sadao

  May 2004, International Journal Of Urology, Vol. 11, No. 5, pp. 257-263, English

  [Refereed]

  Scientific journal


• 【大動脈手術における脊髄保護】 脊髄保護に関する集学的アプローチ 胸腹部大動脈瘤の手術成績

  HANAFUSA,Yuji, OKADA, Kenji, 三村剛史, KAWANISHI, Yujiro, OZAKI,Nobuchika, YAMASHITA,Teruo, TSUJI,Yoshihiko, OKITA, Yutaka

  Apr. 2004, 胸部外科, 57巻, 4号, pp. 313-318, Japanese

  [Refereed]

  Scientific journal


• 脳合併症予知因子の検討

  HANAFUSA,Yuji, TSUKUBE,Takuro, MATSUDA,Hitoshi, OKADA, Kenji, OZAKI,Nobuchika, 日野裕, TANAKA, Hiroshi, 岩崎倫明, 原口知則, 吉田和則, 松森正術, 田中陽介, TSUJI,Yoshihiko, OKITA, Yutaka

  Mar. 2004, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 52巻, Suppl., pp. 87-87, Japanese

  International conference proceedings


• 透析患者に対する心大血管手術

  KITAGAWA, Atsushi, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Mar. 2004, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 52巻, Suppl., pp. 92-92, Japanese

  International conference proceedings


• 大動脈弁輪部膿瘍に対する基部置換術

  松森正術, 田中陽介, 岩崎倫明, 原口知則, 吉田和則, TANAKA, Hiroshi, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Mar. 2004, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 52巻, Suppl., pp. 109-109, Japanese

  International conference proceedings


• 大動脈炎症候群合併病変に対する外科治療

  田中陽介, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Mar. 2004, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 52巻, Suppl., pp. 128-128, Japanese

  International conference proceedings


• 多腔解離を来たした大動脈解離の手術症例の検討

  国久智成, TSUJI,Yoshihiko, 野村拓生, 橋本章太郎, 宗像宏, 田中陽介, 溝口和博, 日野裕, OZAKI,Nobuchika, OKADA, Kenji, OKITA, Yutaka

  Mar. 2004, 日本外科学会雑誌, 105巻, 臨増, pp. 452-452, Japanese

  International conference proceedings


• 縦隔炎に対するVAC(Vacuum-assisted suction drainage)の検討

  吉田和則, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Mar. 2004, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 52巻, Suppl., pp. 131-131, Japanese

  International conference proceedings


• 胸腹部大動脈手術における術中脊髄保護の臨床成績

  岩崎倫明, 田中陽介, 松森正術, 原口知則, 吉田和則, TANAKA, Hiroshi, KITAGAWA, Atsushi, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Mar. 2004, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 52巻, Suppl., pp. 109-109, Japanese

  International conference proceedings


• 胸部大動脈瘤術前冠動脈病変スクリーニングの検討

  日野裕, HANAFUSA,Yuji, YAMASHITA,Teruo, OZAKI,Nobuchika, OKADA, Kenji, TSUJI,Yoshihiko, OKITA, Yutaka

  Mar. 2004, 日本外科学会雑誌, 105巻, 臨増, pp. 575-575, Japanese

  International conference proceedings


• 胸部大動脈領域のPenetrating Atherosclerotic Ulcerに対する治療

  日野裕, HANAFUSA,Yuji, 尾崎義就, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Mar. 2004, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 52巻, Suppl., pp. 126-126, Japanese

  International conference proceedings


• 胸部下行,胸腹部大動脈瘤手術における,術前後の脊髄MRI,MRAの意義

  三村剛史, 太田壮美, 宗像宏, 松森正術, 山田章貴, 原口知則, 溝口和博, 日野裕, ハナフサ・ユウジ, YAMASHITA,Teruo, OZAKI,Nobuchika, OKADA, Kenji, TSUJI,Yoshihiko, OKITA, Yutaka

  Mar. 2004, 日本外科学会雑誌, 105巻, 臨増, pp. 444-444, Japanese

  International conference proceedings


• 急性B型大動脈解離に合併した大動脈分枝灌流障害(malperfusion)に対する血管内治療

  溝口和博, TSUJI,Yoshihiko, OKADA, Kenji, OZAKI,Nobuchika, HANAFUSA,Yuji, 日野裕, 太田壮美, 山田章貴, 野村佳克, SUGIMOTO,Kouji, OKITA, Yutaka

  Mar. 2004, 日本外科学会雑誌, 105巻, 臨増, pp. 572-572, Japanese

  International conference proceedings


• 弓部大動脈全置換術の実際

  OKITA, Yutaka, OKADA, Kenji, OZAKI,Nobuchika, YAMASHITA,Teruo, HANAFUSA,Yuji, 日野裕, 溝口和博, 松森正術, 太田壮美, 宗像宏, 原口知則, 山田章貴, 三村剛史, TSUJI,Yoshihiko

  Mar. 2004, 日本外科学会雑誌, 105巻, 臨増, pp. 168-168, Japanese

  International conference proceedings


• 感染性胸部及び胸腹部大動脈瘤の外科治療

  HANAFUSA,Yuji, TSUJI,Yoshihiko, OKADA, Kenji, OZAKI,Nobuchika, YAMASHITA,Teruo, 日野裕, 溝口和博, 原口知則, 松森正術, 山田章貴, 太田壮美, 三村剛史, 宗像弘, OKITA, Yutaka

  Mar. 2004, 日本外科学会雑誌, 105巻, 臨増, pp. 695-695, Japanese

  International conference proceedings


• 胃癌を合併した心大血管手術症例の検討

  TSUJI,Yoshihiko, 原口知則, 日野裕, HANAFUSA,Yuji, YAMASHITA,Teruo, OZAKI,Nobuchika, OKADA, Kenji, WATANABE,Yoshihisa, OKITA, Yutaka

  Mar. 2004, 日本外科学会雑誌, 105巻, 臨増, pp. 233-233, Japanese

  International conference proceedings


• Penetrating Atherosclerotic Ulcerに対するStent Graft内挿術の検討

  太田壮美, TSUJI,Yoshihiko, OKADA, Kenji, OZAKI,Nobuchika, YAMASHITA,Teruo, HANAFUSA,Yuji, 日野裕, OKITA, Yutaka

  Mar. 2004, 日本外科学会雑誌, 105巻, 臨増, pp. 444-444, Japanese

  International conference proceedings


• Bentall術後の大動脈炎症候群に対し全弓部置換術を施行した一例

  松森正術, 田中陽介, 岩崎倫明, 原口知則, 吉田和則, TANAKA, Hiroshi, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Mar. 2004, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 52巻, Suppl., pp. 128-128, Japanese

  International conference proceedings


• AMIによるBlow-out LV ruptureの3例

  藤田靖之, 岩崎倫明, 田中陽介, 原口知則, 吉田和則, TANAKA, Hiroshi, 北川敦史, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Mar. 2004, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 52巻, Suppl., pp. 134-134, Japanese

  International conference proceedings


• AAE,AR症例に対するST junction plicationの検討

  松森正術, YAMASHITA,Teruo, HANAFUSA,Yuji, 日野裕, 溝口和博, OZAKI,Nobuchika, OKADA, Kenji, TSUJI,Yoshihiko, OKITA, Yutaka

  Mar. 2004, 日本外科学会雑誌, 105巻, 臨増, pp. 687-687, Japanese

  International conference proceedings


• 91歳弓部大動脈瘤破裂の一治験例

  中川暁雄, 田中陽介, 松森正術, 岩崎倫明, 原口知明, 吉田和則, TANAKA, Hiroshi, KITAGAWA, Atsushi, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Mar. 2004, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 52巻, Suppl., pp. 127-127, Japanese

  International conference proceedings


• 80歳以上の胸部大動脈手術の成績と問題点

  TANAKA, Hiroshi, OKITA, Yutaka, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko

  Mar. 2004, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 52巻, Suppl., pp. 128-128, Japanese

  International conference proceedings


• 腹部大動脈瘤術後に合併した腸管虚血の検討

  日野裕, HANAFUSA,Yuji, YAMASHITA,Teruo, OZAKI,Nobuchika, OKADA, Kenji, TSUJI,Yoshihiko, OKITA, Yutaka

  Feb. 2004, 日本心臓血管外科学会雑誌, 33巻, Suppl., pp. 474-474, Japanese

  International conference proceedings


• 腹部大動脈瘤手術を要する弓部大動脈瘤全置換術症例の検討

  山田章貴, 宗像宏, 田中陽介, 三村剛史, 太田壮美, 松森正術, 原口智徳, HANAFUSA,Yuji, OZAKI,Nobuchika, YAMASHITA,Teruo, OKADA, Kenji, TSUJI,Yoshihiko, OKITA, Yutaka

  Feb. 2004, 日本心臓血管外科学会雑誌, 33巻, Suppl., pp. 355-355, Japanese

  International conference proceedings


• 特発性上腸間膜動脈限局性解離に対する1手術例

  TSUJI,Yoshihiko, 日野裕, OKADA, Kenji, MATSUDA,Hitoshi, OKITA, Yutaka

  Feb. 2004, 日本腹部救急医学会雑誌, 24巻, 2号, pp. 506-506, Japanese

  International conference proceedings


• 大動脈ステントグラフトの遠隔成績 再手術例の検討を中心に

  TSUJI,Yoshihiko, 宗像宏, 田中陽介, KITAGAWA, Atsushi, 日野裕, HANAFUSA,Yuji, OZAKI,Nobuchika, TANIGUCHI, Takanori, SUGIMOTO,Kouji, OKADA, Kenji, MATSUDA,Hitoshi, OKITA, Yutaka

  Feb. 2004, 日本心臓血管外科学会雑誌, 33巻, Suppl., pp. 376-376, Japanese

  International conference proceedings


• 消化管-胸部大動脈瘻症例の検討

  宗像宏, TSUJI,Yoshihiko, 国久智成, 三村剛司, 太田壮美, 山田彰貴, 松森正術, 原口知則, 日野裕, HANAFUSA,Yuji, YAMASHITA,Teruo, OZAKI,Nobuchika, OKADA, Kenji, OKITA, Yutaka

  Feb. 2004, 日本心臓血管外科学会雑誌, 33巻, Suppl., pp. 412-412, Japanese

  International conference proceedings


• 術前肝機能低下症例(ICG15分値≧20%)の手術成績

  田中陽介, HANAFUSA,Yuji, OZAKI,Nobuchika, YAMASHITA,Teruo, OKADA, Kenji, TSUJI,Yoshihiko, OKITA, Yutaka

  Feb. 2004, 日本心臓血管外科学会雑誌, 33巻, Suppl., pp. 475-475, Japanese

  International conference proceedings


• 左室流出路縫縮術を行ったRoss手術

  YAMASHITA,Teruo, 宗像宏, 三村剛史, 太田壮美, 松森正術, 山田章貴, 国久智成, 原口知則, 溝口和博, 日野裕, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, TSUJI,Yoshihiko, OKITA, Yutaka

  Feb. 2004, 日本心臓血管外科学会雑誌, 33巻, Suppl., pp. 218-218, Japanese

  International conference proceedings


• 胸腹部大動脈及び腸骨動脈領域に発生した吻合部瘤に対する治療成績

  田中陽介, HANAFUSA,Yuji, OZAKI,Nobuchika, YAMASHITA,Teruo, OKADA, Kenji, TSUJI,Yoshihiko, OKITA, Yutaka

  Feb. 2004, 日本心臓血管外科学会雑誌, 33巻, Suppl., pp. 412-412, Japanese

  International conference proceedings


• Ross手術の中期成績の検討

  松森正術, YAMASHITA,Teruo, 溝口和博, 日野裕, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, TSUJI,Yoshihiko, OKITA, Yutaka

  Feb. 2004, 日本心臓血管外科学会雑誌, 33巻, Suppl., pp. 199-199, Japanese

  International conference proceedings


• Kommerell憩室瘤の経験

  太田壮美, OKADA, Kenji, OZAKI,Nobuchika, TSUJI,Yoshihiko, YAMASHITA,Teruo, 日野裕, HANAFUSA,Yuji, 高梨秀一郎, 山本晋, OKITA, Yutaka

  Feb. 2004, 日本心臓血管外科学会雑誌, 33巻, Suppl., pp. 288-288, Japanese

  International conference proceedings


• Transbrachial arterial insertion of aortic occlusion balloon catheter in patients with shock from ruptured abdominal aortic aneurysm.

  Hitoshi Matsuda, Yosuke Tanaka, Yutaka Hino, Ritsu Matsukawa, Nobuchika Ozaki, Kenji Okada, Takuro Tsukube, Yoshihiko Tsuji, Yutaka Okita

  Dec. 2003, Journal of vascular surgery, 38(6) (6), 1293 - 6, English, International magazine

  [Refereed]

  Scientific journal


• 肺動脈瘻を合併した弓部大動脈瘤の一治験例

  藤田靖之, 岩崎倫明, 田中陽介, 原口知則, 吉田和則, TANAKA, Hiroshi, 北川敦史, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Oct. 2003, Circulation Journal, 67巻, Suppl.III, pp. 989-989, Japanese

  International conference proceedings


• 同時期に発見された肺癌と心大血管病変に対する外科療法の検討

  YOSHIMURA, Masahiro, MANIWA, Yoshimasa, 中井玲子, 岩永幸一郎, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Oct. 2003, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 51巻, 増刊, pp. 457-457, Japanese

  International conference proceedings


• 大動脈基部病変に対するreimplantation(David法)とRoss手術の術後心エコーの比較検討

  松森正術, 田中陽介, 原口知則, 岩崎倫明, 吉田和則, TANAKA, Hiroshi, KAWANISHI, Yujiro, KITAGAWA, Atsushi, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Oct. 2003, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 51巻, 増刊, pp. 368-368, Japanese

  International conference proceedings


• 胸部大動脈に対するステントグラフト治療の問題点とその対策

  TSUJI,Yoshihiko, 田中陽介, TANAKA, Hiroshi, 日野裕, HANAFUSA,Yuji, OZAKI,Nobuchika, SUGIMOTO,Kouji, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, OKITA, Yutaka

  Oct. 2003, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 51巻, 増刊, pp. 420-420, Japanese

  International conference proceedings


• 60歳代症例に対する生体弁移植の中期遠隔期成績

  日野裕, HANAFUSA,Yuji, 尾崎義就, OKADA, Kenji, TSUJI,Yoshihiko, OKITA, Yutaka

  Oct. 2003, The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, 51巻, 増刊, pp. 412-412, Japanese

  International conference proceedings


• The growth inhibitory effect of p21 adenovirus on androgen-dependent and -independent human prostate cancer cells

  GOTOH,Akinobu, SHIRAKAWA, Toshiro, WADA,Yoshitaka, FUJISAWA, Masato, OKADA,Hiroshi, KAMIDONO,Sadao, Hamada K

  Aug. 2003, Bju International, Vol. 92, No. 3, pp. 314-318, English

  [Refereed]

  Scientific journal


• 修正大血管転位症と診断され,19年後に高度左側房室弁逆流症に対して弁置換術を行った成人女性の1例

  田中秀和, KAWAI, Hiroya, 井関治, 野瀬貴久, 溝口貴裕, INOUE,Nobutaka, YOKOYAMA, Mitsuhiro, OKADA, Kenji, OKITA, Yutaka

  Jul. 2003, 日本小児循環器学会雑誌, 19巻, 4号, pp. 445-445, Japanese

  International conference proceedings


• 閉塞性動脈硬化症に対する血行再建術の治療成績

  KITAGAWA, Atsushi, 田中陽介, 岩崎倫明, 松森正術, TANAKA, Hiroshi, 原口知則, 吉田和則, 日野裕, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Jun. 2003, 日本血管外科学会雑誌, 12巻, 3号, pp. 323-323, Japanese

  International conference proceedings


• 複雑病変に対するendovascular surgeryの有用性

  MATSUDA,Hitoshi, 田中陽介, TANAKA, Hiroshi, 日野裕, HANAFUSA,Yuji, OZAKI,Nobuchika, SUGIMOTO,Kouji, OKADA, Kenji, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Jun. 2003, 日本血管外科学会雑誌, 12巻, 3号, pp. 408-408, Japanese

  International conference proceedings


• 腹部大動脈瘤破裂の検討

  吉田和則, OKITA, Yutaka, TSUJI,Yoshihiko, TSUKUBE,Takuro, MATSUDA,Hitoshi, OKADA, Kenji, OZAKI,Nobuchika, HANAFUSA,Yuji

  Jun. 2003, 日本血管外科学会雑誌, 12巻, 3号, pp. 353-353, Japanese

  International conference proceedings


• 当科における急性肺動脈塞栓症の治療経験

  日野裕, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Jun. 2003, 日本血管外科学会雑誌, 12巻, 3号, pp. 292-292, Japanese

  International conference proceedings


• 大動脈炎症候群合併病変に対する外科治療

  松森正術, 田中陽介, 岩崎倫明, 原口知則, 吉田和則, TANAKA, Hiroshi, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Jun. 2003, 日本血管外科学会雑誌, 12巻, 3号, pp. 279-279, Japanese

  International conference proceedings


• 臓器虚血を伴った急性大動脈解離の治療戦略

  TANAKA, Hiroshi, 原口知則, 日野裕, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, SUGIMOTO,Kouji, OKITA, Yutaka

  Jun. 2003, 日本血管外科学会雑誌, 12巻, 4号, pp. 512-512, Japanese

  International conference proceedings


• 胸腹部大動脈瘤の術後成績についての検討 脊髄保護を中心に

  HANAFUSA,Yuji, 日野裕, 田中陽介, 岩崎倫明, 原口知則, TANAKA, Hiroshi, 松森正術, KITAGAWA, Atsushi, 吉田和則, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Jun. 2003, 日本血管外科学会雑誌, 12巻, 3号, pp. 266-266, Japanese

  International conference proceedings


• Suprarenal,pararenal大動脈瘤手術における腎機能への影響

  田中陽介, 日野裕, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Jun. 2003, 日本血管外科学会雑誌, 12巻, 3号, pp. 363-363, Japanese

  International conference proceedings


• MNMSに対する治療法の検討

  岩崎倫明, 田中陽介, 松森正術, 原口知則, 吉田和則, 田中裕, KITAGAWA, Atsushi, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, NAKAMURA,Masahiko, OKITA, Yutaka

  Jun. 2003, 日本血管外科学会雑誌, 12巻, 3号, pp. 345-345, Japanese

  International conference proceedings


• B型解離性大動脈瘤は手術か保存的治療か

  原口知則, TSUJI,Yoshihiko, TSUKUBE,Takuro, MATSUDA,Hitoshi, OKADA, Kenji, OZAKI,Nobuchika, 花房雅治, 日野裕, 田中陽介, KITAGAWA, Atsushi, 松森正術, 吉田和則, 岩崎倫明, TANAKA, Hiroshi, OKITA, Yutaka

  Jun. 2003, 日本血管外科学会雑誌, 12巻, 3号, pp. 384-384, Japanese

  International conference proceedings


• 慢性透析患者に対する心大血管手術

  KITAGAWA, Atsushi, 田中陽介, 岩崎倫明, 松森正術, TANAKA, Hiroshi, KAWANISHI, Yujiro, 日野裕, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Apr. 2003, 日本心臓血管外科学会雑誌, 32巻, Suppl., pp. 155-155, Japanese

  International conference proceedings


• 大動脈基部機能温存を目指した再建術の工夫

  松森正術, 田中陽介, 岩崎倫明, TANAKA, Hiroshi, KAWANISHI, Yujiro, KITAGAWA, Atsushi, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Apr. 2003, 日本外科学会雑誌, 104巻, 臨増, pp. 551-552, Japanese

  International conference proceedings


• 重複大動脈瘤に対する治療戦略

  KITAGAWA, Atsushi, 田中陽介, 松森正術, 岩崎倫明, 原口知則, KAWANISHI, Yujiro, TANAKA, Hiroshi, 日野裕, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Apr. 2003, 日本外科学会雑誌, 104巻, 臨増, pp. 667-667, Japanese

  International conference proceedings


• 広範囲・多発・再発大動脈瘤症例の検討

  田中陽介, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Apr. 2003, 日本外科学会雑誌, 104巻, 臨増, pp. 667-667, Japanese

  International conference proceedings


• 血栓閉塞型大動脈解離(IMH)に対する手術適応

  岩崎倫明, 田中陽介, 松森正術, 田中裕, KAWANISHI, Yujiro, 北川敦, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Apr. 2003, 日本心臓血管外科学会雑誌, 32巻, Suppl., pp. 273-273, Japanese

  International conference proceedings


• ステントレス生体弁(Freestyle弁)の再手術経験

  田中陽介, 松森正術, 岩崎倫明, TANAKA, Hiroshi, KAWANISHI, Yujiro, KITAGAWA, Atsushi, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Apr. 2003, 日本心臓血管外科学会雑誌, 32巻, Suppl., pp. 252-252, Japanese

  International conference proceedings


• Marfan症候群,AAEに対する自己弁温存術式の検討

  松森正術, 田中陽介, 岩崎倫明, TANAKA, Hiroshi, KAWANISHI, Yujiro, KITAGAWA, Atsushi, HANAFUSA,Yuji, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Apr. 2003, 日本心臓血管外科学会雑誌, 32巻, Suppl., pp. 251-251, Japanese

  International conference proceedings


• Bentall手術後の大動脈炎症候群に対し弓部全置換術を施行した一例

  松森正術, OZAKI,Nobuchika, OKADA, Kenji, MATSUDA,Hitoshi, TSUKUBE,Takuro, TSUJI,Yoshihiko, OKITA, Yutaka

  Apr. 2003, Circulation Journal, 67巻, Suppl.II, pp. 827-827, Japanese

  International conference proceedings


• Rib-cross thoracotomy for replacement of the thoracoabdominal or total descending aorta.

  Takuro Tsukube, Masahiro Yoshimura, Hitoshi Matsuda, Kenji Okada, Ritsu Matsukawa, Yutaka Hino, Hirohisa Murakami, Yujiro Kawanishi, Yutaka Okita

  Jan. 2003, Journal of vascular surgery, 37(1) (1), 219 - 21, English, International magazine

  [Refereed]

  Scientific journal


• 人工弁

  岡田 健次, 大北 裕

  JAPANESE SOCIETY FOR ARTIFICIAL ORGANS, Dec. 2002, 人工臓器, 31(3) (3), 79 - 81, Japanese


• Reconstruction of right ventricular outflow tract with stentless xenografts in Ross procedure.

  Takuro Tsukube, Yujiro Kawanishi, Hirohisa Murakami, Yutaka Hino, Ritsu Matsukawa, Nobuchika Ozaki, Kenji Okada, Hitoshi Matsuda, Noboru Wakita, Masami Nishiwaki, Yutaka Okita

  To investigate whether the use of a stentless porcine aortic xenograft can be an alternative for right ventricular outflow tract (RVOT) reconstruction during the Ross procedure, 9 patients underwent the Ross procedure and RVOT reconstruction with a stentless xenograft since January 2000. After the aortic valve was replaced with a pulmonary autograft, a stentless xenograft with a xeno- pericardial roll was implanted in the RVOT. One patient required subsequent aortic valve replacement because of severe regurgitation of the pulmonary autograft. All patients recovered well from the operation. The right ventricle-pulmonary arterial pressure gradient was 18 +/- 7 mm Hg at discharge and was not significantly increased during the 2-year follow-up period. Although 1 patient died of ventricular arrhythmia 5 months after, his cardiac function was normal, and transpulmonary valve pressure was 19 mm Hg in the follow-up. The other 7 patients are currently in New York Heart Association functional Class I. Although long-term follow-up is required to explain the durability, the stentless xenograft with a pericardial roll is considered to be an alternative for reconstruction of the RVOT within 2 years after the Ross procedure.

  Dec. 2002, Artificial organs, 26(12) (12), 1055 - 9, English, International magazine

  Scientific journal

• Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績

  元津 倫幸, 山口 雅人, Hamada Mostafa, 佐々木 康二, 堀之内 宏樹, 上嶋 英介, 岡田 卓也, 祖父江 慶太郎, 後竹 康子, 中井 秀和, 山中 勝弘, 大村 篤史, 岡田 健次, 杉本 幸司, 村上 卓道

  (一社)日本脈管学会, Oct. 2019, 脈管学, 59(Suppl.) (Suppl.), S175 - S175, Japanese


• 【エンドリーク】Type II endoleakの制御を目的とした術前塞栓術

  山口 雅人, 元津 倫幸, 佐々木 康二, 岡田 卓也, 小出 裕, 杉本 幸司, 村上 卓道, 後竹 康子, 中井 秀和, 山中 勝弘, 岡田 健次, 林 太郎, 川崎 竜太, 森 岳樹, 魚谷 健祐, 谷口 尚範, 福田 哲也, 宮本 直和, 坂本 憲昭

  (一社)日本インターベンショナルラジオロジー学会, Sep. 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(1) (1), 28 - 35, Japanese


• Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績

  元津 倫幸, 山口 雅人, 佐々木 康二, 堀之内 宏樹, 谷 龍一郎, 上嶋 英介, 小出 裕, 岡田 卓也, 祖父江 慶太郎, 後竹 康子, 中井 秀和, 山中 勝弘, 岡田 健次, 杉本 幸司, 村上 卓道

  (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 255 - 255, Japanese


• 当院における大動脈解離に対するTEVARの治療成績

  岡田 卓也, 山口 雅人, 佐々木 康二, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 後竹 康子, 中井 秀和, 山中 勝弘, 岡田 健次, 杉本 幸司, 村上 卓道

  (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 259 - 259, Japanese


• 急性大動脈解離患者における術前のフレイル評価と生命予後の関係

  山本 周平, 五味渕 俊仁, 酒井 康成, 石田 昂彬, 三澤 加代子, 岡田 健次

  (一社)日本循環器学会, Mar. 2019, 日本循環器学会学術集会抄録集, 83回, CO2 - 6, Japanese


• Preoperative Embolization for the Prevention of Type II Endoleak

  山口雅人, 元津倫幸, 佐々木康二, 岡田卓也, 小出裕, 杉本幸司, 村上卓道, 後竹康子, 中井秀和, 山中勝弘, 岡田健次, 林太郎, 川崎竜太, 森岳樹, 魚谷健祐, 谷口尚範, 福田哲也, 宮本直和, 坂本憲昭

  2019, 日本インターベンショナルラジオロジー学会雑誌(Web), 34(1) (1)


• Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績

  元津倫幸, 山口雅人, HAMADA Mostafa, 佐々木康二, 堀之内宏樹, 上嶋英介, 岡田卓也, 祖父江慶太郎, 後竹康子, 中井秀和, 山中勝弘, 大村篤史, 岡田健次, 杉本幸司, 村上卓道

  2019, 脈管学(Web), 59(supplement) (supplement)


• Treatment solution by Miyahara et al.: Treatment of choice for aortic arch aneurysm in a patient with cold agglutinin disease.

  Shunsuke Miyahara, Hiroya Kano, Kenji Okada, Yutaka Okita

  May 2015, Interactive cardiovascular and thoracic surgery, 20(5) (5), 687 - 8, English, International magazine


• EVAR後type II endoleakに対する治療成績

  野村 佳克, 山中 勝弘, 深瀬 圭吾, 後竹 康子, 小原 大見, 井澤 直人, 白坂 知識, 宮原 俊介, 坂本 敏仁, 井上 武, 松森 正術, 山口 雅人, 杉本 幸司, 岡田 健次, 大北 裕

  (NPO)日本血管外科学会, Apr. 2014, 日本血管外科学会雑誌, 23(2) (2), 396 - 396, Japanese


• OP-098-7 異型大動脈縮窄症に対するextra-anatomical bypass(EAB)の検討(OP-098 大血管 胸部・その他,一般演題,第114回日本外科学会定期学術集会)

  村上 優, 松森 正術, 陽川 孝樹, 後竹 康子, 小原 大見, 井澤 直人, 白坂 知識, 宮原 俊介, 山中 勝弘, 坂本 敏仁, 野村 佳克, 深瀬 圭吾, 井上 武, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2014, 日本外科学会雑誌, 115(2) (2), 489 - 489, Japanese


• OP-097-3 解離性大動脈瘤のTEVAR術後に生じた大動脈食道ろうに対して根治術を思考した1例(OP-097 心臓 その他,一般演題,第114回日本外科学会定期学術集会)

  後竹 康子, 野村 佳克, 宮原 俊介, 山中 勝弘, 村上 優, 陽川 考樹, 小原 大見, 井澤 直人, 白坂 知識, 坂本 敏仁, 深瀬 圭吾, 井上 武, 松森 正術, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2014, 日本外科学会雑誌, 115(2) (2), 486 - 486, Japanese


• OP-097-7 慢性血栓塞栓性肺高血圧症手術症例の検討(OP-097 心臓 その他,一般演題,第114回日本外科学会定期学術集会)

  中井 秀和, 村上 優, 陽川 孝樹, 後竹 康子, 白坂 知識, 宮原 俊介, 山中 勝弘, 井澤 直人, 坂本 敏仁, 野村 佳克, 井上 武, 松森 正術, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2014, 日本外科学会雑誌, 115(2) (2), 487 - 487, Japanese


• PS-097-7 急性Stanford A型大動脈解離に対する大動脈基部置換術の遠隔期成績(PS-097 大血管 その他,ポスターセッション,第114回日本外科学会定期学術集会)

  宮原 俊介, 井澤 直人, 白坂 知識, 山中 勝弘, 坂本 敏仁, 野村 佳克, 深瀬 圭吾, 井上 武, 松森 正術, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2014, 日本外科学会雑誌, 115(2) (2), 769 - 769, Japanese


• PS-095-6 腎動脈下大動脈の屈曲がEVAR後の長期成績に与える影響(PS-095 大血管 ステントグラフト1,ポスターセッション,第114回日本外科学会定期学術集会)

  野村 佳克, 山中 勝弘, 深瀬 圭吾, 井戸口 孝二, 山口 雅人, 杉本 幸司, 村上 優, 陽川 孝樹, 後竹 康子, 小原 大見, 井澤 直人, 宮原 俊介, 白坂 知識, 坂本 敏仁, 井上 武, 松森 正術, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2014, 日本外科学会雑誌, 115(2) (2), 765 - 765, Japanese


• PS-170-5 人工血管が存在する縦隔洞炎に対する持続吸引洗浄の有用性(PS-170 心臓 その他-2,ポスターセッション,第114回日本外科学会定期学術集会)

  陽川 孝樹, 村上 優, 後竹 康子, 小原 大見, 井澤 直人, 白坂 知識, 宮原 俊介, 山中 勝弘, 坂本 敏仁, 野村 佳克, 深瀬 圭吾, 井上 武, 松森 正術, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2014, 日本外科学会雑誌, 115(2) (2), 915 - 915, Japanese


• 腎動脈下大動脈の屈曲がEVAR後の長期成績に与える影響

  野村 佳克, 山中 勝弘, 深瀬 圭吾, 井戸口 孝二, 山口 雅人, 杉本 幸司, 村上 優, 陽川 孝樹, 後竹 康子, 小原 大見, 井澤 直人, 宮原 俊介, 白坂 知識, 坂本 敏仁, 井上 武, 松森 正術, 岡田 健次, 大北 裕

  (一社)日本外科学会, Mar. 2014, 日本外科学会雑誌, 115(臨増2) (臨増2), 765 - 765, Japanese


• 循環器病の診断と治療に関するガイドライン(2011年度合同研究班報告) 【ダイジェスト版】弁膜疾患の非薬物治療に関するガイドライン(2012年改訂版)

  大北 裕, 岡田 行功, 尾辻 豊, 米田 正始, 中谷 敏, 松崎 益徳, 吉田 清, 小林 順二郎, 澤 芳樹, 高梨 秀一郎, 渡辺 弘之, Okada Kenji, 黒澤 博身, 高本 眞一, 鄭 忠和, 吉川 純一

  Jul. 2013, 日本心臓血管外科学会雑誌, 42(4号) (4号), 1 - 27, Japanese

  [Invited]

  Introduction scientific journal


• Surgical treatment for aortic periannular abscess/pseudoaneurysm caused by infective endocarditis.

  Kenji Okada, Yutaka Okita

  Apr. 2013, General thoracic and cardiovascular surgery, 61(4) (4), 175 - 81, English, Domestic magazine

  [Refereed]


• RSF-12-4 異型大動脈縮窄症に対し非解剖学バイパス術を行った1例(RSF 研修医の発表セッション,第113回日本外科学会定期学術集会)

  村上 優, 大村 篤史, 小原 大見, 山中 勝弘, 南 一司, 中井 秀和, 木下 史子, 後竹 康子, 白坂 知識, 宮原 俊介, 坂本 敏仁, 竹歳 秀人, 野村 佳克, 井上 武, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2013, 日本外科学会雑誌, 114(2) (2), 1079 - 1079, Japanese


• PS-159-6 腹部大動脈瘤形成過程における酸化ストレスの重要性(PS ポスターセッション,第113回日本外科学会定期学術集会)

  森本 圭介, 岡田 健次, 包 烏蘭, 干 潔, 魚 振海, 田中 亜紀子, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2013, 日本外科学会雑誌, 114(2) (2), 741 - 741, Japanese


• PS-034-2 活動期感染性心内膜炎に対する僧帽弁形成術(PS ポスターセッション,第113回日本外科学会定期学術集会)

  南 一司, 木下 史子, 後竹 康子, 中井 秀和, 小原 大見, 竹歳 秀人, 山中 勝弘, 宮原 俊介, 白坂 知識, 野村 佳克, 坂本 敏仁, 大村 篤史, 井上 武, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2013, 日本外科学会雑誌, 114(2) (2), 564 - 564, Japanese


• PS-030-1 超高齢者大動脈弁狭窄に対する大動脈弁置換術からの検討 : どのような症例に低侵襲治療が望まれるか(PS ポスターセッション,第113回日本外科学会定期学術集会)

  井上 武, 木下 史子, 後竹 康子, 中井 秀和, 小原 大見, 竹歳 秀人, 山中 勝弘, 白坂 知識, 野村 佳克, 坂本 敏仁, 大村 篤史, 南 一司, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2013, 日本外科学会雑誌, 114(2) (2), 559 - 559, Japanese


• PS-279-3 弓部大動脈置換術におけるThromboelastometry(ROTEM(R))の使用経験(PS ポスターセッション,第113回日本外科学会定期学術集会)

  中井 秀和, 木下 史子, 後竹 康子, 小原 大見, 白坂 知識, 宮原 俊介, 竹歳 秀人, 大村 篤史, 坂本 敏仁, 野村 佳克, 井上 武, 南 一司, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2013, 日本外科学会雑誌, 114(2) (2), 910 - 910, Japanese


• PD-10-5 急性A型大動脈解離の遠隔成績(PD パネルディスカッション,第113回日本外科学会定期学術集会)

  大村 篤史, 山中 勝弘, 小原 大見, 南 一司, 中井 秀和, 木下 史子, 後竹 康子, 白坂 知識, 宮原 俊介, 坂本 敏仁, 竹歳 秀人, 野村 佳克, 井上 武, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2013, 日本外科学会雑誌, 114(2) (2), 254 - 254, Japanese


• SF-040-5 エダラボンの抗酸化作用によるラット腹部大動脈瘤抑制効果の検討(SF-040 サージカルフォーラム(40)大血管 基礎,第112回日本外科学会定期学術集会)

  森本 圭介, 長谷川 智巳, 田中 亜紀子, 包 鳥蘭, 于 潔, 森本 直人, 大北 裕, 岡田 健次

  一般社団法人日本外科学会, 05 Mar. 2012, 日本外科学会雑誌, 113(2) (2), 339 - 339, Japanese


• SF-041-1 高齢者における大動脈弓部全置換術(SF-041 サージカルフォーラム(41)大血管 胸部,第112回日本外科学会定期学術集会)

  岡田 健次, 大村 篤史, 佐藤 雅信, 小原 大見, 山中 勝弘, 宮原 俊介, 白坂 知識, 坂本 敏仁, 田中 亜紀子, 井上 武, 岡 隆紀, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2012, 日本外科学会雑誌, 113(2) (2), 339 - 339, Japanese


• SF-040-3 アスコルビン酸徐放ハイドロゲルシートを用いた大動脈瘤の抑制(続報)(SF-040 サージカルフォーラム(40)大血管 基礎,第112回日本外科学会定期学術集会)

  田中 亜紀子, 小原 大見, 白坂 知識, 宮原 俊介, 山中 勝弘, 大村 篤史, 坂本 敏仁, 野村 佳克, 井上 武, 岡 隆紀, 南 一司, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2012, 日本外科学会雑誌, 113(2) (2), 338 - 338, Japanese


• VWS-1-5 機能的重症憎帽弁逆流に対する自己弁温存憎帽弁置換術の治療成績(VWS-1 ビデオワークショップ(1)機能的僧帽弁逆流に対する術式の工夫,第112回日本外科学会定期学術集会)

  吉田 和則, 宮原 俊介, 山中 勝弘, 大村 篤史, 坂本 敏仁, 野村 佳克, 田中 亜紀子, 井上 武, 岡 隆紀, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2012, 日本外科学会雑誌, 113(2) (2), 261 - 261, Japanese


• PS-105-8 脳内酸素モニタリングは大動脈弓部全置換術後の覚醒遅延を予測しうるか?(PS-105 大血管 胸部,ポスターセッション,第112回日本外科学会定期学術集会)

  白坂 知識, 岡田 健次, 加納 寛也, 佐藤 雅信, 小原 大見, 宮原 俊介, 山中 勝弘, 大村 篤史, 坂本 敏仁, 野村 佳克, 田中 亜紀子, 井上 武, 岡 隆紀, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2012, 日本外科学会雑誌, 113(2) (2), 702 - 702, Japanese


• VSY-6-5 当科における大動脈弁温存手術(VSY-6 ビデオシンポジウム(6)大動脈弁形成術および大動脈弁温存手術-適応と術式-,第112回日本外科学会定期学術集会)

  岡 隆紀, 佐藤 雅信, 竹歳 秀人, 小原 大見, 白坂 知識, 山中 勝弘, 宮原 俊介, 野村 佳克, 坂本 敏仁, 大村 篤史, 田中 亜紀子, 井上 武, 南 一司, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2012, 日本外科学会雑誌, 113(2) (2), 184 - 184, Japanese


• PS-154-1 自己弁温存大動脈基部置換術前後の弁形状の変化が遠隔期AR再発に及ぼす影響(心臓弁膜症,ポスターセッション,第112回日本外科学会定期学術集会)

  宮原 俊介, 小原 大見, 白坂 知識, 山中 勝弘, 大村 篤史, 坂本 敏仁, 野村 佳克, 田中 亜紀子, 井上 武, 岡 隆紀, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2012, 日本外科学会雑誌, 113(2) (2), 799 - 799, Japanese


• PS-153-6 ステントレス生体弁を用いた成人期右室流出路再建後の遠隔成績 : Ross手術を含めて(心臓小児・弁膜症,ポスターセッション,第112回日本外科学会定期学術集会)

  井上 武, 小原 大見, 佐藤 雅信, 宮原 俊介, 山中 勝弘, 白坂 知識, 野村 佳克, 坂本 敏仁, 大村 篤史, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2012, 日本外科学会雑誌, 113(2) (2), 798 - 798, Japanese


• SF-107-3 胸部大動脈感染病変に対する治療経験(SF-107 サージカルフォーラム(107)大血管 胸腹部,第112回日本外科学会定期学術集会)

  山中 勝弘, 佐藤 雅信, 小原 大見, 白坂 知識, 宮原 俊介, 野村 佳克, 坂本 敏仁, 大村 篤史, 田中 亜紀子, 井上 武, 岡 隆起, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2012, 日本外科学会雑誌, 113(2) (2), 431 - 431, Japanese


• Free Radical Scavenger Edaravone Inhibited Both Aneurysmal Formation and Progression in Rat Abdominal Aortic Aneurysm Model

  Keisuke Morimoto, Tomomi Hasegawa, Akiko Tanaka, Naoto Morimoto, Yutaka Okita, Kenji Okada

  Nov. 2011, CIRCULATION, 124(21) (21), English

  Summary international conference


• WS-5-3 Marfan症候群におけ心大血管病変に対する治療(WS5 ワークショップ(5)心大血管病変を有するマルファン症候群に対する集学的治療,第111回日本外科学会定期学術集会)

  田中 亜紀子, 宮原 俊介, 大村 篤史, 坂本 敏仁, 野村 拓生, 野村 佳克, 藤田 靖之, 宗像 宏, 岡 隆紀, 南 一司, 北川 敦士, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 25 May 2011, 日本外科学会雑誌, 112(1) (1), 294 - 294, Japanese


• SF-065-2 弁形成術を加えた自己弁温存大動脈基部置換術の中期遠隔成績(SF-065 サージカルフォーラム(65)心臓:手術-1,第111回日本外科学会定期学術集会)

  岡 隆紀, 佐藤 雅信, 宮原 俊介, 野村 拓生, 野村 佳克, 坂本 敏仁, 大村 篤史, 藤田 靖之, 田中 亜紀子, 宗像 宏, 井上 武, 南 一司, 北川 敦士, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 25 May 2011, 日本外科学会雑誌, 112(1) (1), 416 - 416, Japanese


• PS-007-1 心臓血管外科領域における重症患者の栄養状態悪化の危険因子の検討(PS-007 ポスターセッション(7)心臓:周術期管理-2,第111回日本外科学会定期学術集会)

  宮原 俊介, 佐藤 雅信, 白坂 知識, 大村 厚史, 坂本 敏仁, 野村 拓生, 野村 佳克, 田中 亜紀子, 藤田 靖之, 宗像 宏, 井上 武, 岡 隆紀, 南 一司, 北川 敦士, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 25 May 2011, 日本外科学会雑誌, 112(1) (1), 518 - 518, Japanese


• PS-006-5 ナファモスタットメシル酸塩併用によるヘパリンを減量した体外循環の検討(PS-006 ポスターセッション(6)心臓:周術期管理-1,第111回日本外科学会定期学術集会)

  坂本 敏仁, 佐藤 雅信, 宮原 俊介, 大村 篤史, 野村 拓生, 野村 佳克, 田中 亜紀子, 藤田 靖之, 宗像 宏, 井上 武, 北川 敦士, 岡 隆紀, 南 一司, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 25 May 2011, 日本外科学会雑誌, 112(1) (1), 517 - 517, Japanese


• VW-6-8 TEVAR後の合併症に対する再開胸症例の検討(VW6 ビデオワークショップ(6) 胸部大動脈疾患に対する手技的工夫,第111回日本外科学会定期学術集会)

  井上 武, 佐藤 雅信, 白坂 知識, 宮原 俊介, 大村 篤史, 坂本 敏仁, 野村 佳克, 野村 拓生, 田中 亜紀子, 藤田 靖之, 宗像 宏, 岡 隆紀, 南 一司, 北川 敦士, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 25 May 2011, 日本外科学会雑誌, 112(1) (1), 320 - 320, Japanese


• SF-101-2 急性B型大動脈解離遠隔期の成績(サージカルフォーラム(101)大血管:手術-1,第111回日本外科学会定期学術集会)

  宗像 宏, 佐藤 雅信, 白坂 知識, 宮原 俊介, 野村 拓生, 野村 佳克, 坂本 敏仁, 大村 篤史, 田中 亜紀子, 井上 武, 岡 隆紀, 南 一司, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 25 May 2011, 日本外科学会雑誌, 112(1) (1), 461 - 461, Japanese


• OP-178-1 大動脈弁形成術の手術・遠隔期成績(心臓-6,一般口演,第110回日本外科学会定期学術集会)

  野村 佳克, 白坂 知識, 野村 拓生, 坂本 敏仁, 大村 篤史, 田中 亜紀子, 宗像 宏, 松森 正術, 岡 隆紀, 長谷川 智巳, 南 一司, 北川 敦士, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2010, 日本外科学会雑誌, 111(2) (2), 560 - 560, Japanese


• SV-2-3-1 自己弁を温存した大動脈基部置換術(心臓・血管-3,特別ビデオセッション2,第110回日本外科学会定期学術集会)

  大北 裕, 松森 正術, 宗像 宏, 南 和司, 岡 隆紀, 岡田 健次

  一般社団法人日本外科学会, 05 Mar. 2010, 日本外科学会雑誌, 111(2) (2), 51 - 51, Japanese


• SF-065-4 自己弁温存大動脈基部置換術再手術症例の検討(心臓,サージカルフォーラム,第110回日本外科学会定期学術集会)

  松森 正術, 白坂 知識, 坂本 敏仁, 野村 拓生, 野村 佳克, 大村 篤史, 藤田 靖之, 田中 亜紀子, 宗像 宏, 南 一司, 長谷川 智己, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2010, 日本外科学会雑誌, 111(2) (2), 266 - 266, Japanese


• OP-160-5 胸腹部大動脈瘤手術における肋間動脈再建の検討(大血管-4,一般口演,第110回日本外科学会定期学術集会)

  大村 篤史, 泉 聡, 田中 亜紀子, 宗像 宏, 松森 正術, 岡 隆紀, 南 一司, 長谷川 智巳, 北川 敦士, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2010, 日本外科学会雑誌, 111(2) (2), 537 - 537, Japanese


• OP-267-3 大動脈瘤形成における組織型トランスグルタミナーゼの役割に関する実験的検討(血管基礎,一般口演,第110回日本外科学会定期学術集会)

  長谷川 智巳, 宗実 孝, 蘇日 他拉, 田中 亜紀子, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2010, 日本外科学会雑誌, 111(2) (2), 700 - 700, Japanese


• OP-267-5 ピオグリタゾン徐放ゼラチンシートによる静脈グラフト劣化抑制効果に関する実験的検討(血管基礎,一般口演,第110回日本外科学会定期学術集会)

  陳 志, 長谷川 智巳, 田中 亜紀子, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2010, 日本外科学会雑誌, 111(2) (2), 700 - 700, Japanese


• SF-050-5 アスコルビン酸徐放ゼラチンシートを用いた大動脈瘤発生の抑制(血管-1,サージカルフォーラム,第110回日本外科学会定期学術集会)

  田中 亜紀子, 陳 志, 長谷川 智巳, 岡田 健次, 田畑 康彦, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2010, 日本外科学会雑誌, 111(2) (2), 246 - 246, Japanese


• SF-050-3 B型大動脈解離の遠隔期おける偽腔血流形態の重要性(血管-1,サージカルフォーラム,第110回日本外科学会定期学術集会)

  宗像 宏, 白坂 知識, 野村 拓生, 野村 佳克, 大村 篤史, 坂本 敏仁, 藤田 靖之, 松森 正術, 南 一司, 岡 隆紀, 長谷川 智巳, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2010, 日本外科学会雑誌, 111(2) (2), 246 - 246, Japanese


• OP-007-4 高齢者弁膜症手術の成績と問題点(心・高齢者-2,一般口演,第110回日本外科学会定期学術集会)

  南 一司, 白坂 知識, 野村 拓生, 野村 佳克, 坂本 敏仁, 大村 篤史, 藤田 靖之, 田中 亜紀子, 宗像 宏, 松森 正術, 岡 隆紀, 北川 敦士, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2010, 日本外科学会雑誌, 111(2) (2), 309 - 309, Japanese


• OP-177-2 両側もしくは片側内胸動脈使用が冠動脈バイパス術遠隔成績に与える影響(心臓-5,一般口演,第110回日本外科学会定期学術集会)

  岡田 健次, 大村 篤志, 白坂 知識, 野村 拓生, 野村 佳克, 坂本 敏仁, 藤田 靖之, 田中 亜紀子, 宗像 宏, 松森 正術, 岡 隆紀, 南 一司, 北川 敦士, 長谷川 智己, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2010, 日本外科学会雑誌, 111(2) (2), 560 - 560, Japanese


• OP-173-5 上行大動脈遮断を要する心臓手術における術後脳合併症リスクの検討(心臓-1,一般口演,第110回日本外科学会定期学術集会)

  白坂 知識, 田中 亜希子, 宗像 宏, 松森 正術, 岡 隆紀, 南 一司, 長谷川 智巳, 北川 敦士, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2010, 日本外科学会雑誌, 111(2) (2), 556 - 556, Japanese


• OP-173-4 出血性合併症を有する患者に対する体外循環時ヘパリン減量のための工夫 : メシル酸ナファモスタットを併用した抗凝固による体外循環(心臓-1,一般口演,第110回日本外科学会定期学術集会)

  坂本 敏仁, 白坂 知識, 大村 篤史, 野村 拓生, 野村 佳克, 田中 亜紀子, 藤田 靖之, 宗像 宏, 松森 正術, 岡 隆紀, 北川 敦士, 南 一司, 長谷川 智巳, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2010, 日本外科学会雑誌, 111(2) (2), 556 - 556, Japanese


• 第40回日本心臓血管外科学術集会印象記

  Okada Kenji

  2010, 循環制御, 31巻, 1, pp. 1-3, Japanese

  Introduction scientific journal


• 心臓血管外科学研究の進歩

  Okada Kenji

  2010, 循環器専門医, 18巻, 2, pp. 312-316, Japanese

  Introduction scientific journal


• 急性A型大動脈解離を未然に防ぐ上行大動脈置換術

  Okada Kenji

  Nov. 2009, 循環器科, 66巻, 5号, pp. 550-554, Japanese

  Introduction scientific journal


• 人工臓器としてのステントグラフト 素材とデザインの問題点 自作ステントグラフトによるTEVARの遠隔成績

  北川 敦士, 田中 亜希子, 宗像 宏, 松森 正術, 南 一司, 長谷川 智巳, 岡田 健次, 山口 雅人, 杉本 幸司, 杉村 和朗, 大北 裕

  (一社)日本人工臓器学会, Oct. 2009, 人工臓器, 38(2) (2), S - 37, Japanese


• [Does aortic cusp repair influence the outcome of valve sparing aortic root replacement?]

  Okada Kenji

  Oct. 2009, Kyobu Geka, 62(11) (11), 971 - 7, English

  [Refereed]

  Introduction scientific journal


• 【臨床に必要な感染性心内膜炎の知識】 外科治療 手術手技を中心に

  Okada Kenji

  Jun. 2009, CIRCULATION Up-to-Date, 4巻, 3号, pp. 347-354, Japanese

  Introduction scientific journal


• EVAR : Is it Available for Most of Japanese AAA Patients?

  KITAGAWA Atsushi, OKADA Kenji, HASEGAWA Tomomi, MINAMI Kazushi, MATSUMORI Masamichi, MUNAKATA Hiroshi, NOMURA Yoshikatsu, YAMAGUCHI Masato, SUGIYAMA Kazuro, SUGIMOTO Koji

  14 Apr. 2009, 日本血管外科学会雑誌 = The Japanese journal of vascular surgery : official journal of the Japanese Society for Vascular Surgery, 18(2) (2), 145 - 145, English


• 医療コストからみた血管外科治療 胸部下行大動脈瘤における医療コストの比較 Open surgery vs TEVAR

  野村 佳克, 北川 敦士, 大北 裕, 岡田 健次, 長谷川 智巳, 南 一司, 松森 正術, 宗像 宏, 高橋 宏明, 田中 亜紀子, 大村 篤史, 坂本 敏仁, 山口 雅人, 杉村 和朗, 杉本 幸司

  (NPO)日本血管外科学会, Apr. 2009, 日本血管外科学会雑誌, 18(2) (2), 182 - 182, Japanese


• 当院に於ける腹部大動脈瘤に対するステントグラフトの早期成績と適応の限界

  野村 佳克, 北川 敦士, 白坂 知識, 坂本 敏仁, 大村 篤史, 野村 拓生, 田中 亜希子, 高橋 宏明, 宗像 宏, 松森 正樹, 長谷川 智巳, 岡田 健次, 大北 裕, 山口 雅人, 杉本 幸司

  (NPO)日本血管外科学会, Apr. 2009, 日本血管外科学会雑誌, 18(2) (2), 292 - 292, Japanese


• 緊急手術を要する胸部下行大動脈瘤の治療選択 胸部下行大動脈破裂 TEVARとopen surgeryの比較と問題点

  北川 敦士, 大北 裕, 岡田 健次, 長谷川 智己, 南 一司, 松森 正術, 宗像 宏, 野村 佳克, 田中 亜希子, 高橋 宏明, 泉 聡, 大村 篤史, 山口 雅人, 杉村 和朗, 杉本 幸司

  (NPO)日本心臓血管外科学会, Mar. 2009, 日本心臓血管外科学会雑誌, 38(Suppl.) (Suppl.), 134 - 134, Japanese


• HP-095-7 感染性胸部大動脈瘤に対する治療方針(大血管1,ハイブリッドポスター,第109回日本外科学会定期学術集会)

  中井 秀和, 小原 大見, 白坂 知識, 野村 拓生, 野村 佳克, 坂本 敏仁, 大村 篤史, 泉 聡, 田中 亜紀子, 高橋 宏明, 宗像 宏, 松森 正術, 北川 敦士, 長谷川 智巳, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 25 Feb. 2009, 日本外科学会雑誌, 110(2) (2), 558 - 558, Japanese


• SF-096-6 ピオグリタゾンによる静脈グラフト劣化抑制効果に関する実験的検討(大血管4,サージカルフォーラム,第109回日本外科学会定期学術集会)

  陳 志, 岡田 健次, 長谷川 智巳, 田中 亜紀子, 大北 裕

  一般社団法人日本外科学会, 25 Feb. 2009, 日本外科学会雑誌, 110(2) (2), 344 - 344, Japanese


• SF-065-5 自己弁温存大動脈基部置換術に及ぼす大動脈基部径の影響(心臓1,サージカルフォーラム,第109回日本外科学会定期学術集会)

  松森 正術, 中井 秀和, 小原 大見, 白坂 知識, 坂本 敏仁, 野村 拓生, 野村 佳克, 大村 篤史, 田中 亜紀子, 高橋 宏明, 宗像 宏, 長谷川 智巳, 北川 敦士, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 25 Feb. 2009, 日本外科学会雑誌, 110(2) (2), 306 - 306, Japanese


• VW-2-5 神戸大学病院における弓部大動脈瘤手術のスタンダード(虚血性心臓病と胸部大動脈瘤-教育病院における手術のスタンダード,ビデオワークショップ,第109回日本外科学会定期学術集会)

  長谷川 智巳, 中井 秀和, 白坂 知識, 坂本 敏仁, 大村 篤史, 野村 拓生, 野村 佳克, 田中 亜紀子, 高橋 宏明, 宗像 宏, 松森 正術, 北川 敦志, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 25 Feb. 2009, 日本外科学会雑誌, 110(2) (2), 182 - 182, Japanese


• SF-096-2 大動脈遮断中の血圧が脊髄虚血に及ぼす影響に関する実験的検討(大血管4,サージカルフォーラム,第109回日本外科学会定期学術集会)

  泉 聡, 岡田 健次, 長谷川 智巳, 大北 裕

  一般社団法人日本外科学会, 25 Feb. 2009, 日本外科学会雑誌, 110(2) (2), 343 - 343, Japanese


• HP-119-5 狭小大動脈弁輪症例に対する生体弁置換術症例の検討(心臓:後天性疾患(手術1),ハイブリッドポスター,第109回日本外科学会定期学術集会)

  高橋 宏明, 田中 亜紀子, 宗像 宏, 松森 正術, 長谷川 智巳, 北川 敦士, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 25 Feb. 2009, 日本外科学会雑誌, 110(2) (2), 599 - 599, Japanese


• VSY-3-6 弁輪破壊症例に対する弁膜症再手術症例の検討(心臓弁膜症に対する外科治療-弁膜症再手術のpitfalls-,ビデオシンポジウム,第109回日本外科学会定期学術集会)

  岡田 健次, 高橋 宏明, 中井 秀和, 白坂 知識, 野村 拓生, 坂本 敏仁, 大村 篤志, 田中 亜紀子, 宗像 宏, 松森 正術, 長谷川 智己, 大北 裕

  一般社団法人日本外科学会, 25 Feb. 2009, 日本外科学会雑誌, 110(2) (2), 117 - 117, Japanese


• 血管外科におけるカテーテル治療 胸部大動脈破裂に対する検討 TEVAR vs open surgery

  北川 敦士, 大北 裕, 岡田 健次, 長谷川 智己, 松森 正術, 宗像 宏, 野村 佳克, 山口 雅人, 杉村 和朗, 杉本 幸司

  (一社)日本外科学会, Feb. 2009, 日本外科学会雑誌, 110(臨増2) (臨増2), 185 - 185, Japanese


• In situで自己組織化するTissue-Engineered Vascular wall patchの肺動脈移植実験の検討

  高橋宏明, 澤芳樹, 内村英一郎, 齋藤充弘, 加来永一, 平川公一郎, 岡田健次, 大北裕

  2009, 医工学治療, 21(Supplement) (Supplement)


• 日本人におけるEVAR(Endovascular Aneurysm Repair)の解剖学的適合性

  北川 敦士, 大北 裕, 岡田 健次, 森本 喜久, 松森 正術, 宗像 宏, 川崎 竜太, 山口 雅人, 杉村 和朗, 杉本 幸司

  (一社)日本インターベンショナルラジオロジー学会, Jan. 2009, IVR: Interventional Radiology, 24(Suppl.) (Suppl.), 28 - 29, Japanese


• 【感染性心臓・大動脈疾患の治療】 感染性心内膜炎 大動脈弁および大動脈弁位人工弁

  Okada Kenji

  Jan. 2009, 日本外科学会雑誌, 110巻, 1号, pp. 7-11, Japanese

  Introduction scientific journal


• [Surgery for aortic valve endocarditis].

  Kenji Okada, Yutaka Okita

  Infective endocarditis is a life-threatening disease that should be diagnosed based on Duke's criteria as early as possible. A positive blood culture and echocardiographic findings, particularly those of a transesophageal echocardiogram, play a pivotal role in the process of confirming a diagnosis. Medical treatment using appropriate antibiotics against the identified microorganism is of primary importance, although infective endocarditis is often accompanied by intracardiac or extracardiac complications and must be converted to surgery. The timing of surgery for patients with brain complications is crucial but still controversial because the usage of heparin for cardiopulmonary bypass (CPB) may cause the complications to deteriorate. We demonstrated that a novel CPB strategy with nafamostat mesilate as an anticoagulant may be potentially safe and useful in preventing deterioration of recent intracranial hemorrhage. Destructive aortic valve endocarditis causes the development of left ventricular-aortic discontinuity. In the past 8 years, 9 patients with left ventricular-aortic discontinuity underwent aortic root replacement in our institution. Radical debridement of the aortic root abscess was performed in all cases, followed by aortic root replacement with a pulmonary autograft (Ross procedure) or a stentless aortic root xenograft. No mortality was observed during hospitalization and follow-up. Freedom from major adverse cardiac events was noted in 67% of the patients at 5 years.

  Jan. 2009, Nihon Geka Gakkai zasshi, 110(1) (1), 7 - 11, Japanese, Domestic magazine


• 136) 大動脈弁断裂の1例(第105回日本循環器学会近畿地方会)

  今西 純一, 高野 貴継, 正井 博之, 清水 雅俊, 三輪 陽一, 岡田 健次, 大北 裕

  社団法人日本循環器学会, 20 Oct. 2008, Circulation journal : official journal of the Japanese Circulation Society, 72, 1106 - 1106, Japanese


• 194) San Diego分類3型慢性肺動脈血栓塞栓症に対する肺動脈内膜摘除術(第105回日本循環器学会近畿地方会)

  森本 直人, 坂本 敏仁, 野村 拓生, 田中 亜紀子, 高橋 宏明, 宗像 宏, 松森 正術, 北川 敦士, 森本 喜久, 岡田 健次, 大北 裕

  社団法人日本循環器学会, 20 Oct. 2008, Circulation journal : official journal of the Japanese Circulation Society, 72, 1112 - 1112, Japanese


• 【大動脈瘤 基礎と臨床】 急性大動脈解離に対する外科治療と問題点

  Okada Kenji

  Sep. 2008, 医学のあゆみ, 226巻, 10号, pp. 905-913, Japanese

  Introduction scientific journal


• 【手術手順・看護のポイントがわかる 実践心臓血管外科手術マニュアル】 心臓血管外科領域で扱う疾患 弁膜疾患

  Okada Kenji

  Sep. 2008, オペナーシング, 巻, 2008秋季増刊, pp. 14-23, Japanese

  Introduction scientific journal


• Stenting of Left Main Trunk Occlusion due to Type A Aortic Dissection as a Bridge to Definitive Surgery

  SHIMIZU Masatoshi, MATSUKAWA Ritsu, OKADA Kenji, TAKANO Takatsugu, MASAI Hiroyuki, OKITA Yutaka

  日本心臓病学会, 15 Jul. 2008, J Cardiol Jpn Ed, 2(1) (1), 62 - 68, Japanese


• DP-107-2 血栓閉鎖型急性A型大動脈解離に対する治療成績(第108回日本外科学会定期学術集会)

  田中 亜紀子, 小竹 淳一朗, 宮原 俊介, 坂本 敏仁, 野村 拓生, 泉 聡, 高橋 英樹, 高橋 宏明, 宗像 宏, 森本 直人, 浅野 満, 松森 正術, 北川 敦士, 森本 喜久, 岡田 健次

  一般社団法人日本外科学会, 25 Apr. 2008, 日本外科学会雑誌, 109(2) (2), 558 - 558, Japanese


• DP-109-2 イヌ全脳虚血モデルを使用した再還流障害軽減のための研究(第108回日本外科学会定期学術集会)

  宗像 宏, 岡田 健次, 日野 裕, 泉 聡, 野村 拓生, 坂本 敏仁, 田中 亜紀子, 森本 直人, 高橋 英樹, 松森 正術, 浅野 満, 北川 敦士, 森本 喜久, 大北 裕

  一般社団法人日本外科学会, 25 Apr. 2008, 日本外科学会雑誌, 109(2) (2), 562 - 562, Japanese


• VS-2-4 活動期感染性心内膜炎,僧帽弁閉鎖不全に対する外科治療のTips and Pitfall(第108回日本外科学会定期学術集会)

  浅野 満, 宮原 俊介, 野村 拓生, 坂本 敏仁, 田中 亜紀子, 泉 聡, 高橋 英樹, 森本 直人, 宗像 宏, 松森 正術, 北川 敦士, 森本 喜久, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 25 Apr. 2008, 日本外科学会雑誌, 109(2) (2), 104 - 104, Japanese


• PD-2-4 頚動脈病変を伴うCABG症例の周術期脳梗塞予防戦略(第108回日本外科学会定期学術集会)

  岡田 健次, 泉 聡, 野村 拓生, 宮原 俊介, 坂本 敏仁, 田中 亜紀子, 高橋 英樹, 高橋 宏明, 宗像 宏, 森本 直人, 松森 正術, 浅野 満, 森本 喜久, 大北 裕

  一般社団法人日本外科学会, 25 Apr. 2008, 日本外科学会雑誌, 109(2) (2), 122 - 122, Japanese


• SF-018-5 全身血圧の脊髄虚血に及ぼす影響に関する実験的検討(第108回日本外科学会定期学術集会)

  泉 聡, 岡田 健次, Bishow Pokhrel, 小竹 淳一朗, 宮原 俊介, 坂本 敏仁, 野村 拓生, 田中 亜紀子, 高橋 英樹, 高橋 宏明, 森本 直人, 宗像 宏, 浅野 満, 松森 正術, 北川 敦士, 森本 喜久, 大北 裕

  一般社団法人日本外科学会, 25 Apr. 2008, 日本外科学会雑誌, 109(2) (2), 209 - 209, Japanese


• VD-008-2 術中大動脈解離の経験に学ぶ(第108回日本外科学会定期学術集会)

  森本 喜久, 岡田 健次, 浅野 満, 松森 正術, 北川 敦士, 森本 直人, 宗像 宏, 泉 聡, 高橋 英樹, 田中 亜紀子, 大北 裕

  一般社団法人日本外科学会, 25 Apr. 2008, 日本外科学会雑誌, 109(2) (2), 331 - 331, Japanese


• SY-2-3 血管再建後の人工血管感染に対する治療戦略(第108回日本外科学会定期学術集会)

  松森 正術, 小竹 淳一郎, 宮原 俊介, 野村 拓生, 坂本 敏仁, 泉 聡, 田中 亜紀子, 森本 直人, 高橋 英樹, 高橋 宏明, 宗像 宏, 浅野 満, 北川 敦士, 森本 善久, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 25 Apr. 2008, 日本外科学会雑誌, 109(2) (2), 89 - 89, Japanese


• SF-060-1 Scaffoldのみで生体内で自己組織化するTissue-Engineered Vascular wall patch(第108回日本外科学会定期学術集会)

  高橋 宏明, 澤 芳樹, 齋藤 充弘, 加来 永一, 平川 公一郎, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 25 Apr. 2008, 日本外科学会雑誌, 109(2) (2), Japanese


• 179) 部分肺静脈還流異常症の一例(第104回日本循環器学会近畿地方会)

  福田 優子, 江本 憲昭, 宮川 一也, 則定 加津子, 川森 裕之, 志手 淳也, 川合 宏哉, 吉田 明弘, 平田 健一, 田中 亜紀子, 松森 正術, 岡田 健次, 大北 裕

  社団法人日本循環器学会, 20 Apr. 2008, Circulation journal : official journal of the Japanese Circulation Society, 72, 1003 - 1003, Japanese


• 3 Contemporary Surgical Outcome for Thoracic Aortic Aneurysms(Symposium 4 (SY-04) (H) Recent Progress in the Treatment of Aortic Diseases,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Okada Kenji, Nakagiri Keitaro, Morimoto Yoshihisa, Asano Mitsuru, Matsumori Masamichi, Okita Yutaka

  Japanese Circulation Society, 01 Mar. 2008, Circulation journal : official journal of the Japanese Circulation Society, 72, 31 - 31, English


• EVAR for AAA 日本人における適応と限界

  北川 敦士, 大北 裕, 岡田 健次, 森本 喜久, 松森 正術, 浅野 満, 宗像 宏, 川崎 竜太, 杉村 和朗, 杉本 幸司

  (NPO)日本血管外科学会, Mar. 2008, 日本血管外科学会雑誌, 17(2) (2), 369 - 369, Japanese


• Scaffoldのみで生体内で自己組織化するTissue-Engineered Vascular wall patch

  高橋宏明, 澤芳樹, 齋藤充弘, 加来永一, 平川公一郎, 岡田健次, 大北裕

  2008, 日本外科学会雑誌, 109


• 143)肺動脈血栓内膜摘除術が奏功した若年発症の慢性肺動脈血栓塞栓症の一例(第103回日本循環器学会近畿地方会)

  浜田 晶子, 山下 智也, 吉田 明弘, 多和 秀人, 川森 裕之, 井上 通彦, 則定 加津子, 江本 憲昭, 川合 宏哉, 志手 淳也, 平田 健一, 横山 光宏, 松森 正術, 田中 裕史, 岡田 健次, 大北 裕

  社団法人日本循環器学会, 20 Oct. 2007, Circulation journal : official journal of the Japanese Circulation Society, 71, 1005 - 1005, Japanese


• 103)特異な病理所見を呈した大動脈弁閉鎖不全症に対しBentall手術を施行した1例(第103回日本循環器学会近畿地方会)

  山中 勝弘, 田中 亜紀子, 高橋 英樹, 高橋 宏明, 宗像 宏, 森本 直人, 松森 正術, 浅野 満, 北川 敦士, 川西 雄二郎, 田中 裕史, 中桐 啓太郎, 岡田 健次, 大北 裕, 大林 千穂, 植田 初枝, 由谷 親夫

  社団法人日本循環器学会, 20 Oct. 2007, Circulation journal : official journal of the Japanese Circulation Society, 71, 1000 - 1000, Japanese


• 【心不全 最新の基礎・臨床研究の進歩】 心不全の原因疾患(基礎疾患)別の臨床的事項 病態、発症機序(心不全)、治療 弁膜症 三尖弁閉鎖不全症

  Okada Kenji

  May 2007, 日本臨床, 65巻, 増刊5 心不全(下), pp. 512-516, Japanese

  Introduction scientific journal


• 腎動脈灌流障害を合併したB型大動脈解離に対する血管内治療の1例

  北川 敦士, 大北 裕, 岡田 健次, 中桐 啓太郎, 田中 裕史, 川西 雄二郎, 松森 正術, 宗像 宏, 山中 勝弘, 谷口 尚範, 川崎 竜太, 杉村 良朗, 杉本 幸司

  (NPO)日本血管外科学会, Apr. 2007, 日本血管外科学会雑誌, 16(3) (3), 603 - 603, Japanese


• 大動脈瘤に対するステントグラフト治療の遠隔成績と問題点 胸部下行大動脈疾患に対するステントグラフト手術の成績

  北川 敦士, 大北 裕, 岡田 健次, 中桐 啓太郎, 田中 裕史, 川西 雄二郎, 松森 正術, 宗像 宏, 高橋 英樹, 山中 勝宏, 谷口 尚範, 川崎 竜太, 杉本 和朗, 杉本 幸司

  (NPO)日本血管外科学会, Apr. 2007, 日本血管外科学会雑誌, 16(2) (2), 282 - 282, Japanese


• DP-036-1 B型大動脈解離の急性期手術症例の検討(第107回日本外科学会定期学術集会)

  浅野 満, 岡田 健次, 中桐 啓太郎, 田中 裕史, 川西 雄二郎, 松森 正術, 宗像 宏, 高橋 英樹, 泉 聡, 山中 勝弘, 大北 裕

  一般社団法人日本外科学会, 10 Mar. 2007, 日本外科学会雑誌, 108(2) (2), 400 - 400, Japanese


• 胸腹部大動脈瘤に対する治療戦略

  川西 雄二郎, 泉 聡, 宗像 宏, 高橋 英樹, 松森 正術, 浅野 満, 田中 裕史, 北川 敦士, 中桐 啓太郎, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 10 Mar. 2007, 日本外科学会雑誌, 108, 120 - 120, Japanese


• DP-033-6 急性大動脈解離に対する弓部部分置換術施行時の断端形成と遠隔期予後(第107回日本外科学会定期学術集会)

  田中 裕史, 岡田 健次, 中桐 啓太郎, 川西 雄二郎, 北川 敦士, 浅野 満, 松森 正術, 宗像 宏, 泉 聡, 高橋 英樹, 大北 裕

  一般社団法人日本外科学会, 10 Mar. 2007, 日本外科学会雑誌, 108(2) (2), 397 - 397, Japanese


• DP-103-3 感染性大動脈疾患に対するビタミンC及びバンコマイシン含浸徐放性ゼラチンシート被覆自家静脈グラフトの有用性に関する実験的検討(第107回日本外科学会定期学術集会)

  原口 知則, 岡田 健次, 田畑 泰彦, 真庭 謙昌, 大北 裕

  一般社団法人日本外科学会, 10 Mar. 2007, 日本外科学会雑誌, 108(2) (2), 530 - 530, Japanese


• 2 Surgical Treatment for Infective Endocarditis(Various Problems Encountered in the Course of Medical Treatment, and Timing of Surgical Therapy for Infective Endocarditis, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Okada Kenji, Matsumori Masamichi, Tanaka Hiroshi, Kawanishi Yujiro, Nakagiri Keitaro, Okita Yutaka

  Japanese Circulation Society, 01 Mar. 2007, Circulation journal : official journal of the Japanese Circulation Society, 71, 62 - 62, English


• 3 Current Surgery for Thoracic Aortic Aneurysm(Open surgery or Endovascular Repair for Aortic Aneurysm, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Nakagiri Keitaro, Yamanaka Katsuhiro, Tanaka Akiko, Izumi Satoshi, Takahashi Hideki, Munakata Hiroshi, Takahashi Hiroaki, Morimoto Naoto, Matsumori Masatsugu, Asano Mitsuru, Tanaka Hiroshi, Kawanishi Yujiro, Kitagawa Atsushi, Okada Kenji

  Japanese Circulation Society, 01 Mar. 2007, Circulation journal : official journal of the Japanese Circulation Society, 71, 56 - 56, English


• 胸部下行大動脈緊急破裂例に対する血管内治療の成績

  北川 敦士, 大北 裕, 岡田 健次, 中桐 啓太郎, 田中 裕史, 川西 雄二郎, 松森 正術, 浅野 満, 宗像 宏, 森本 直人, 泉 聡, 高橋 英樹, 上村 亮介, 山中 勝弘, 杉本 幸司, 谷口 尚範

  (一社)日本外科学会, Mar. 2007, 日本外科学会雑誌, 108(臨増2) (臨増2), 322 - 322, Japanese


• 97)胸部大動脈瘤に合併した急性B型大動脈解離の一例(第101回日本循環器学会近畿地方会)

  浅野 満, 岡田 健次, 山下 輝夫, 中桐 啓太郎, 田中 裕史, 川西 雄二郎, 松森 正術, 宗像 宏, 森本 直人

  社団法人日本循環器学会, 20 Oct. 2006, Circulation journal : official journal of the Japanese Circulation Society, 70, 1226 - 1226, Japanese


• 59)左肩急性化膿性関節炎と脳膿瘍を合併した活動性感染性心内膜炎に対する僧帽弁形成術の経験(第101回日本循環器学会近畿地方会)

  宗像 宏, 岡田 健次, 国久 智成, 森本 直人, 前川 貴代, 北原 淳一郎, 松森 正術, 浅野 満, 川西 雄二郎, 田中 裕史, 中桐 啓太郎, 山下 輝夫, 大北 裕

  社団法人日本循環器学会, 20 Oct. 2006, Circulation journal : official journal of the Japanese Circulation Society, 70, 1221 - 1221, Japanese


• Cell fusion was not essential for cardiomyogenesis from bone marrow stem cells

  Atsushi Kitagawa, Kenji Okada, Yutaka Okita, Richard D. Weisel, Donald A. G. Mickle, Ren-Ke Li

  Sep. 2006, CIRCULATION RESEARCH, 99(5) (5), E37 - E37, English

  Summary international conference


• 慢性肺動脈塞栓症に対する外科治療

  圓尾 文子, 大北 裕, 岡田 健次, 中桐 啓太郎, 山下 輝夫, 川西 雄二郎, 浅野 満, 松森 正術, 大田 壮美, 前川 貴代, 森本 直人, 宗像 宏, 坂本 敏仁

  一般社団法人日本外科学会, 05 Mar. 2006, 日本外科学会雑誌, 107(2) (2), 457 - 457, Japanese


• 大動脈弁手術における弁形成術の検討

  宗像 宏, 山下 輝夫, 岡田 健次, 坂本 敏仁, 前川 貴代, 森本 直人, 松森 正術, 浅野 満, 川西 雄二郎, 圓尾 文子, 中桐 啓太郎, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2006, 日本外科学会雑誌, 107(2) (2), 456 - 456, Japanese


• 胸部大動脈瘤に対するステントグラフト挿入術の中期成績

  坂本 敏仁, 森本 直人, 宗像 宏, 前川 貴代, 浅野 満, 松森 正術, 川西 雄二郎, 圓尾 文子, 山下 輝夫, 中桐 啓太郎, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2006, 日本外科学会雑誌, 107(2) (2), 517 - 517, Japanese


• Marfan症候群における大動脈基部置換術

  大北 裕, 松森 正術, 岡田 健次, 山下 輝夫, 中桐 啓太郎, 圓尾 文子, 田中 裕史, 川西 雄二郎, 浅野 満, 宗像 宏, 北原 淳一郎, 前川 貴代, 森本 直人, 国久 智成

  一般社団法人日本外科学会, 05 Mar. 2006, 日本外科学会雑誌, 107(2) (2), 146 - 146, Japanese


• 肝硬変合併開心術の術後肝不全発症に関する検討

  森本 直人, 坂本 敏仁, 宗像 宏, 前川 貴代, 松森 正術, 浅野 満, 川西 雄二郎, 中桐 啓太郎, 山下 輝夫, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2006, 日本外科学会雑誌, 107(2) (2), 281 - 281, Japanese


• 弁形成を追加した自己弁温存大動脈基部置換術の検討

  松森 正術, 坂本 敏仁, 森本 直人, 宗像 宏, 前川 貴代, 浅野 満, 川西 雄二郎, 圓尾 文子, 中桐 啓太郎, 山下 輝夫, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2006, 日本外科学会雑誌, 107(2) (2), 282 - 282, Japanese


• 変性疾患による僧帽弁閉鎖不全症に対する治療戦略の検討

  山下 輝夫, 大北 裕, 岡田 健次, 中桐 啓太郎, 圓尾 文子, 川西 雄二郎, 浅野 満, 松森 正術, 太田 壮美, 前川 貴代, 森本 直人, 宗像 宏, 坂本 敏仁

  一般社団法人日本外科学会, 05 Mar. 2006, 日本外科学会雑誌, 107(2) (2), 708 - 708, Japanese


• 肋間動脈を介するsteal現象が脊髄血流に及ぼす影響

  川西 雄二郎, 坂本 敏仁, 森本 直人, 宗像 宏, 前川 貴代, 松森 正術, 浅野 満, 圓尾 文子, 中桐 啓太郎, 山下 輝夫, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2006, 日本外科学会雑誌, 107(2) (2), 211 - 211, Japanese


• 大動脈基部病変を伴ったMarfan症候群に対する自己弁温存手術の検討

  岡田 健次, 松森 正術, 坂本 敏仁, 森本 直人, 前川 貴代, 宗像 宏, 川西 雄二郎, 浅野 満, 圓尾 文子, 中桐 啓太郎, 山下 輝夫, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2006, 日本外科学会雑誌, 107(2) (2), 212 - 212, Japanese


• 急性大動脈解離に対するReimplantation法の検討

  浅野 満, 岡田 健次, 坂本 敏仁, 森本 直人, 前川 貴代, 宗像 宏, 松森 正術, 川西 雄二郎, 中桐 啓太郎, 圓尾 文子, 山下 輝夫, 大北 裕

  一般社団法人日本外科学会, 05 Mar. 2006, 日本外科学会雑誌, 107(2) (2), 518 - 518, Japanese


• bFGF 含浸ゼラチンシートによるラット静脈グラフトの至 適動脈化に関する研究

  原口知則, 岡田健次, 真庭謙昌, 田畑泰彦, 大北裕

  2006, 第9 回日本組織工学会（2006.9.7－8. 京都）, Japanese

  [Refereed]


• 胸部大動脈瘤に対するステントグラフト内挿術の適応と問題点

  森本 直人, 松本 倫, 松森 正術, 太田 壮美, 川西 雄二郎, 圓尾 文子, 谷口 尚範, 森本 喜久, 山下 輝夫, 杉本 幸司, 岡田 健次, 大北 裕

  (NPO)日本血管外科学会, Jun. 2005, 日本血管外科学会雑誌, 14(3) (3), 360 - 360, Japanese


• 高齢者に対する胸部大動脈瘤手術の問題点と対策(第105回日本外科学会定期学術集会)

  岡田 健次, 森本 直人, 松森 正術, 山田 章貴, 川西 雄二郎, 田中 裕史, 森本 喜久, 山下 輝夫, 辻 義彦, 大北 裕

  一般社団法人日本外科学会, 05 Apr. 2005, 日本外科学会雑誌, 106, 566 - 566, Japanese


• 自己フィブリンコート小口径人工血管の開発(第105回日本外科学会定期学術集会)

  長谷川 智巳, 岡田 健次, 高野 良仁, 平石 嘉昭, 大北 裕

  一般社団法人日本外科学会, 05 Apr. 2005, 日本外科学会雑誌, 106, 574 - 574, Japanese


• Marfan 症候群に対する大動脈基部置換術の検討(第105回日本外科学会定期学術集会)

  松本 倫, 森本 直人, 太田 壮美, 山田 章貴, 松森 正樹, 川西 雄二郎, 田中 裕史, 森本 喜久, 山下 輝夫, 岡田 健次, 辻 義彦, 大北 裕

  一般社団法人日本外科学会, 05 Apr. 2005, 日本外科学会雑誌, 106, 567 - 567, Japanese


• 僧帽弁位感染性心内膜炎に対する弁形成術(第105回日本外科学会定期学術集会)

  山下 輝夫, 大北 裕, 岡田 健次, 森本 喜久, 田中 裕史, 川西 雄二郎, 松森 正術, 山田 章貴, 太田 壮美, 森本 直人

  一般社団法人日本外科学会, 05 Apr. 2005, 日本外科学会雑誌, 106, 106 - 106, Japanese


• 頚動脈狭窄を合併した虚血性心疾患に対する治療戦略(第105回日本外科学会定期学術集会)

  森本 直人, 松森 正術, 山田 章貴, 川西 雄二郎, 田中 裕史, 森本 喜久, 山下 輝夫, 辻 義彦, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Apr. 2005, 日本外科学会雑誌, 106, 265 - 265, Japanese


• 上行大動脈拡大を有する大動脈二尖弁に対する大動脈置換術の検討(第105回日本外科学会定期学術集会)

  松森 正術, 森本 直人, 太田 壮美, 山田 章貴, 田中 裕史, 川西 雄二郎, 森本 喜久, 山下 輝夫, 岡田 健次, 辻 義彦, 大北 裕

  一般社団法人日本外科学会, 05 Apr. 2005, 日本外科学会雑誌, 106, 345 - 345, Japanese


• 線維芽細胞増殖因子 (bFGF) 含浸ゼラチンシートがラット静脈グラフトの開存性に及ぼす影響(第105回日本外科学会定期学術集会)

  原口 知則, 岡田 健次, 大北 裕, 田畑 泰彦

  一般社団法人日本外科学会, 05 Apr. 2005, 日本外科学会雑誌, 106, 250 - 250, Japanese


• 胸腹部大動脈瘤手術における脊髄虚血の予測因子の検討(第105回日本外科学会定期学術集会)

  川西 雄二郎, 森本 直人, 松森 正術, 山田 章貴, 田中 裕史, 森本 喜久, 山下 輝夫, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 05 Apr. 2005, 日本外科学会雑誌, 106, 175 - 175, Japanese


• 胸部・腹部大動脈瘤に対する血管内治療と観血的手術の適応 多発性大動脈瘤に対するHybrid治療戦略

  辻 義彦, 森本 直人, 松森 正術, 山田 章貴, 田中 裕史, 川西 雄二郎, 日野 裕, 谷口 尚範, 森本 喜久, 中桐 啓太郎, 山下 輝夫, 杉本 幸司, 岡田 健次, 松田 均, 大北 裕

  (一社)日本外科学会, Apr. 2005, 日本外科学会雑誌, 106(臨増) (臨増), 81 - 81, Japanese


• New Platelet Scintigraphy with ^<99m>Technetium Apcitide to Assess Thrombogenicity of Small Caliber Vascular Prostheses(Nuclear Cardiology 6 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Hasegawa Tomomi, Okada Kenji, Okita Yutaka

  Japanese Circulation Society, 01 Mar. 2005, Circulation journal : official journal of the Japanese Circulation Society, 69, 281 - 281, English


• Cutting Edge 人工弁の現況と将来

  OKADA, Kenji, OKITA, Yutaka

  Feb. 2005, Medical Science Digest, 31巻, 2号, pp. 41-42, Japanese

  Introduction scientific journal


• 胸部・腹部大動脈病変に対するステントグラフト治療の功罪

  辻 義彦, 森本 直人, 山田 章貴, 田中 陽介, 日野 裕, 谷口 尚範, 森本 喜久, 中桐 啓太郎, 山下 輝夫, 岡田 健次, 杉本 幸司, 松田 均, 大北 裕

  (NPO)日本心臓血管外科学会, Jan. 2005, 日本心臓血管外科学会雑誌, 34(Suppl.) (Suppl.), 412 - 412, Japanese


• 人工血管と感染

  辻 義彦, 森本 直人, 太田 壮美, 山田 章貴, 松森 正術, 川西 雄二郎, 田中 裕史, 森本 喜久, 山下 輝夫, 岡田 健次, 吉村 雅裕, 大北 裕

  15 Sep. 2004, 人工臓器, 33(2) (2), S - 39, Japanese


• 大動脈弁位における人工弁の選択について

  山下 輝夫, 大北 裕, 辻 義彦, 岡田 健次, 森本 喜久

  15 Sep. 2004, 人工臓器, 33(2) (2), S - 35, Japanese


• 冠動脈シリーズ 外科的治療

  OKADA, Kenji, OKITA, Yutaka

  Aug. 2004, 兵庫県医師会医学雑誌, 47巻, 1号, pp. 43-48, Japanese

  Introduction scientific journal


• 58) 冠動脈疾患, 僧帽弁閉鎖不全症, 腹部大動脈瘤をともなった高齢者弓部大動脈瘤の一手術例(第96回日本循環器学会近畿地方会)

  山田 章貴, 田中 亜紀子, 松森 正術, 花房 雄治, 岡田 健次, 築部 卓郎, 大北 裕

  社団法人日本循環器学会, 20 Apr. 2004, Circulation journal : official journal of the Japanese Circulation Society, 68, 812 - 812, Japanese


• 胸部・腹部大動脈に発生したpenetrating atherosclerotic ulcer(PAU)の診断と外科治療

  辻 義彦, 田中 陽介, 宗像 宏, 太田 壯美, 山田 章貴, 松森 正術, 溝口 和博, 日野 裕, 谷口 尚範, 花房 雄治, 尾崎 喜就, 山下 輝夫, 岡田 健次, 杉本 幸司, 大北 裕

  (NPO)日本血管外科学会, Apr. 2004, 日本血管外科学会雑誌, 13(2) (2), 156 - 156, Japanese


• 当院における透析シャント不全に対する経皮的血管形成術の経験

  日野 裕, 花房 雄治, 尾崎 喜就, 山下 輝夫, 岡田 健次, 辻 義彦, 山口 雅人, 谷口 尚範, 杉本 幸司, 大北 裕

  (NPO)日本血管外科学会, Apr. 2004, 日本血管外科学会雑誌, 13(2) (2), 339 - 339, Japanese


• PS-147-5 Peroxisome Proliferator-Activated Receptor(PPAR)-γ活性化薬のラット異所性心移植における免疫抑制効果の検討

  田中 陽介, 岡田 健次, 長谷川 智巳, 岡田 守人, 大北 裕

  一般社団法人日本外科学会, 15 Mar. 2004, 日本外科学会雑誌, 105, 567 - 567, Japanese


• PS-149-6 当院における心筋梗塞後合併症に対する外科治療成績

  岡田 健次, 松森 正術, 山田 章貴, 原口 知則, 太田 壮美, 三村 剛史, 宗像 宏, 野村 佳克, 溝口 和博, 日野 裕, 花房 雄治, 山下 輝夫, 尾崎 喜就, 大北 裕

  一般社団法人日本外科学会, 15 Mar. 2004, 日本外科学会雑誌, 105, 571 - 571, Japanese


• PS-073-3 B型大動脈解離の治療成績

  原口 知則, 三村 剛史, 太田 壮美, 松森 正術, 山田 章貴, 国久 智成, 宗像 宏, 溝口 和博, 山下 輝夫, 日野 裕, 花房 雄治, 尾崎 喜就, 岡田 健次, 大北 裕

  一般社団法人日本外科学会, 15 Mar. 2004, 日本外科学会雑誌, 105, 452 - 452, Japanese


• VS-018-5 ラット胎児心筋上清共培養によるラット骨髄細胞から心筋細胞誘導の試み

  北川 敦士, 岡田 健次, 大北 裕, Li Ren-Ke, Weisel Richard D, Mickle Donald A. G.

  一般社団法人日本外科学会, 15 Mar. 2004, 日本外科学会雑誌, 105, 341 - 341, Japanese


• PS-225-3 冠動脈バイパス術に有用な小口径(3mm)人工血管の開発をめざして

  長谷川 智巳, 岡田 健次, 高野 良仁, 平石 嘉昭, 大北 裕

  一般社団法人日本外科学会, 15 Mar. 2004, 日本外科学会雑誌, 105, 686 - 686, Japanese


• PJ-184 Surgical treatment for left ventricular rupture following myocardial infarction(Cardiovascular Surgery/CABG 2 (IHD) : PJ31)(Poster Session (Japanese))

  Yamashita Teruo, Okada Kenji, Matsumori Masamichi, Hino Yutaka, Hanafusa Yuji, Ozaki Nobuchika, Okita Yutaka

  Japanese Circulation Society, 01 Mar. 2004, Circulation journal : official journal of the Japanese Circulation Society, 68, 525 - 525, English


• OJ-124 Aortic regurgitation and annulus size after aortic valve sparing operation for Marfan syndrome(Cardiovascular Surgery/CABG 1 (IHD) : OJ15)(Oral Presentation (Japanese))

  Ozaki Nobuchika, Okada Kenji, Tsuji Yoshihiko, Okita Yutaka

  Japanese Circulation Society, 01 Mar. 2004, Circulation journal : official journal of the Japanese Circulation Society, 68, 261 - 261, English


• PE-329 Penetrating Atherosclerotic Ulcer of the Aorta : Clinical Features and Treatments(Atherosclerosis, Clinical 6 (IHD) : PE56)(Poster Session (English))

  Tsuji Yoshihiko, Hino Yutaka, Ozaki Nobuchika, Okada Kenji, Matsuda Hitoshi, Tsukube Takuro, Okita Yutaka

  Japanese Circulation Society, 01 Mar. 2004, Circulation journal : official journal of the Japanese Circulation Society, 68, 442 - 442, English


• PE-309 The Experiment for improving the patency of the vein graft for CABG(Cardiovascular Surgery/CABG 3 (IHD) : PE53)(Poster Session (English))

  Haraguchi Tomonori, Okada Kenji, Okita Yutaka, Tabata Yasuhiko

  Japanese Circulation Society, 01 Mar. 2004, Circulation journal : official journal of the Japanese Circulation Society, 68, 437 - 437, English


• 腹部大動脈瘤における血管造影検査の意義

  宗像 宏, 岡田 健次, 杉本 幸司, 国久 智成, 三村 剛史, 太田 壮美, 松森 正術, 山田 章貴, 原口 知則, 日野 裕, 花房 雄治, 山下 輝夫, 尾崎 喜就, 大北 裕

  (一社)日本外科学会, Mar. 2004, 日本外科学会雑誌, 105(臨増) (臨増), 574 - 574, Japanese


• 【21世紀初頭の循環器医療を取り巻く社会的諸問題 循環器領域を若手にとって魅力的なものにするために】 改善への提言 大学での研究 外科

  OKADA, Kenji, OKITA, Yutaka

  Feb. 2004, Cardiovascular Med-Surg, 6巻, 1号, pp. 94-96, Japanese

  Introduction scientific journal


• 腸骨動脈ステントグラフト留置後のエンドリークに対しWallstentが有効であった一例

  山口 雅人, 杉本 幸司, Carlos A.Zamora, 岩間 祐基, 伊崎 健太, 鶴崎 正勝, 谷口 尚範, 森 岳樹, 杉村 和朗, 岡田 健次, 松田 均, 辻 義彦, 大北 裕

  (公社)日本医学放射線学会, Jan. 2004, 日本医学放射線学会雑誌, 64(1) (1), 71 - 71, Japanese


• 腹部大動脈瘤手術に血管造影は必要か?

  岡田 健次, 杉本 幸司, 日野 裕, 田中 裕史, 北川 敦士, 岩崎 倫明, 吉田 和則, 原口 知則, 松森 正術, 田中 陽介, 花房 雄治, 尾崎 喜就, 松田 均, 築部 卓郎, 大北 裕

  (NPO)日本血管外科学会, Jun. 2003, 日本血管外科学会雑誌, 12(3) (3), 247 - 247, Japanese


• 胸腹部大動脈手術における術中脊髄虚血障害への対策

  川西 雄二郎, 田中 陽介, 松森 正術, 岩崎 倫明, 田中 裕史, 北川 敦士, 日野 裕, 花房 雄治, 尾崎 喜就, 岡田 健次, 松田 均, 築部 卓郎, 大北 裕

  一般社団法人日本外科学会, 30 Apr. 2003, 日本外科学会雑誌, 104, 669 - 670, Japanese


• 心臓大血管術後感染症対策の標準化

  岡田 健次, 松田 均, 荒川 創一, 木下 承晧, 李 宗子, 黒川 敏子, 西庄 京子, 松川 律, 築部 卓郎, 大北 裕

  一般社団法人日本外科学会, 30 Apr. 2003, 日本外科学会雑誌, 104, 550 - 550, Japanese


• 虚血性心筋症に対する外科治療戦略

  築部 卓郎, 松森 正術, 原口 知則, 岩崎 倫明, 田中 裕史, 川西 雄二郎, 尾崎 喜就, 岡田 健次, 松田 均, 大北 裕

  一般社団法人日本外科学会, 30 Apr. 2003, 日本外科学会雑誌, 104, 490 - 490, Japanese


• 三尖弁形成術の遠隔成績についての検討

  松川 律, 杉 利秀, 田中 陽介, 津川 二郎, 川西 雄二郎, 日野 裕, 岡田 健次, 松田 均, 築部 卓郎, 大北 裕

  一般社団法人日本外科学会, 10 Mar. 2002, 日本外科学会雑誌, 103, 442 - 442, Japanese


• 大動脈弓部置換における左反回神経温存のための工夫

  松田 均, 川西 雄二郎, 日野 裕, 松川 律, 岡田 健次, 築部 卓郎, 大北 裕

  一般社団法人日本外科学会, 10 Mar. 2002, 日本外科学会雑誌, 103, 337 - 337, Japanese


• 胸部下行大動脈,胸腹部大動脈手術におけるMEPの検討

  川西 雄二郎, 村上 博久, 日野 裕, 松川 律, 岡田 健次, 松田 均, 築部 卓郎, 大北 裕

  一般社団法人日本外科学会, 10 Mar. 2002, 日本外科学会雑誌, 103, 329 - 329, Japanese


• 成人大動脈病変に対するRoss手術の検討

  築部 卓郎, 松田 均, 岡田 健次, 尾崎 喜就, 松川 律, 日野 裕, 村上 博久, 川西 雄二郎, 杉 利秀, 大北 裕

  一般社団法人日本外科学会, 10 Mar. 2002, 日本外科学会雑誌, 103, 317 - 317, Japanese


• 胸部・腹部大動脈瘤に対するステントグラフト内挿術の適応条件

  辻 義彦, 宗実 孝, 日野 裕, 松川 律, 岡田 健次, 松田 均, 築部 卓郎, 吉田 正人, 大北 裕

  一般社団法人日本外科学会, 10 Mar. 2002, 日本外科学会雑誌, 103, 107 - 107, Japanese


• Hepatocellular Carcinoma with a Sarcomatous Appearance : Report of a Case

  TSUJI YOSHIHIKO, OKADA KENJI, FUKUOKA MASATO, WATANABE YOSHIHISA, ATAKA KEIJI, MINAMI RIEKO, HANIOKA KEISUKE, TACHIBANA SHIRO, SAITO HIROSHI, SASADA AKINORI, OKITA YUTAKA

  01 Aug. 2001, Surg Today, 31(8) (8), 735 - 739, English


• Effectiveness of Dipyridamole Thallium 201 Scintigraphy in Deciding on Surgical Treatment of Abdominal Aortic Aneurysm Combined with Coronary Artery Disease

  OKADA Kenji, ANDO Motomi, OKITA Yutaka, MOROTA Tetsuro, TAKAMOTO Shinichi, KAWASHIMA Yasunaru

  01 Aug. 1995, 日本血管外科学会雑誌 = The Japanese journal of vascular surgery : official journal of the Japanese Society for Vascular Surgery, 4(4) (4), 543 - 547, Japanese

• 創傷のすべて －キズをもつすべての人のためにー / II 慢性創傷 ３．手術に伴う創傷 縦隔炎・胸骨骨髄炎．安部正敏，溝上祐子，寺師浩人（編）

  Okada Kenji

  Others, 克誠堂出版, 2012, Japanese

  Scholarly book


• 今日の心臓手術の適応と至適時期 / Topics －ステントグラフト治療か人工血管置換術か－

  Okada Kenji

  Joint work, 文光堂, 2011, Japanese

  Scholarly book


• 循環器疾患 最新の治療 2010-2011 / V章 弁膜疾患 7. 弁膜症の外科治療（感染性心内膜炎を除く）

  Okada Kenji

  Joint work, 南江堂, 2010, Japanese

  Scholarly book


• 循環器疾患 最新の治療 2008-2009 Current Therapy in Cardiovascular Disease / 循環器疾患 最新の治療 2008-2009 「II-18 冠動脈バイパス術後の外来管理」

  Okada Kenji

  Joint work, 南江堂, 2008, Japanese

  Scholarly book


• 社会人が学ぶ 医療技術・医療用機器 / 第11章 人工臓器

  Okada Kenji

  Joint work, 財団法人 神戸市産業振興財団, 2008, Japanese

  Textbook


• 「日本臨床」：2007年増刊、心不全（下）、－最新の基礎・臨床研究の進歩－ / 「三尖弁閉鎖不全症」

  OKADA KENJI

  Joint work, 日本臨床社, 2007, Japanese

  Scholarly book


• 「臨床心臓病学」 / 大動脈弁閉鎖不全、弁形成術

  OKADA KENJI

  Joint work, 文光堂, 2006, Japanese

  Textbook


• 「人工臓器・再生医療の最先端」 / ―臨床サイドから見た人工血管の課題―

  OKADA KENJI

  Joint work, 先端医療技術研究所, 2005, Japanese

  Scholarly book


• 「新 心臓血管外科ハンドブック」 / 術中管理 A. 人工心肺 ４. 脳保護法

  OKADA KENJI

  Joint work, 南江堂, 2005, Japanese

  Scholarly book


• Knack & Pitfalls 「弁膜症外科の要点と盲点」 / [X] 再手術のKnack & Pitfalls ２．手術術式（到達法、人工心肺アクセス、癒着剥離など）と手術成績

  OKADA KENJI

  Joint work, 文光堂, 2005, Japanese

  Scholarly book


• 「エキスパートに学ぶ大動脈瘤手術」 / 第Ⅲ章 下行大動脈・胸腹部大動脈瘤 d)超低体温・循環停止（逆行性脳灌流法）

  OKADA KENJI

  Joint work, メディカルレビュー社, 2003, Japanese

  Scholarly book

• 拡張型心筋症に対して植え込み型左室補助人工心臓装着術後、難治性心室頻拍と右心不全加療に難渋した一例

  山下 健太郎, 久松 恵理子, 末廣 英也, 永松 裕一, 黒瀬 潤, TANAKA HIDEKAZU, KIUCHI KUNIHIKO, INOUE TAKESHI, OKADA KENJI, HIRATA KENICHI

  第47回人工心臓と補助循環懇話会学術集会, Feb. 2019, Japanese, 佐賀, 症例は 47 歳女性。20 歳代より労作時呼吸困難を自覚し、39 歳時分娩 中に急性左心不全を発症した。心エコーにて左室拡大を伴うびまん性左 室収縮能低下を認め、拡張型心筋症と考え内服加療を開始したが心機能 の改善を認めず、41 歳時に機能性僧帽弁閉鎖不全症に対して、僧帽弁置 換術および三尖弁輪形成術を施行した。また持続性心室頻拍に対して、 同年 ICD 植込み術を施行した。45 歳時より NYHAⅢ-Ⅳの状態が続き、 BNP 1000-1500pg/mL と高値で推移した。46 歳時に精査加療目的で入院後、 強心剤依存の状態となり、心臓移植適応登録後、同年 11 月植込型左室 補助人工心臓(LVAD)装着術を施行した。術直後は良好な循環動態であっ たが、術後 1 日目より心電図波形が著明な低電位となり、心室頻拍(VT) が出現した。電気的除細動に加, Domestic conference

  Poster presentation


• 拡張型心筋症に対して左室補助人工心臓装着後、微小なくも膜下出血を繰り返し認めた一例

  久松恵理子, 山下健太郎, 永野雄一朗, TANAKA HIDEKAZU, INOUE TAKESHI, OKADA KENJI, HIRATA KENICHI

  第47回人工心臓と補助循環懇話会学術集会, Feb. 2019, Japanese, 佐賀, Domestic conference

  Poster presentation


• 慢性血栓塞栓性肺高血圧症に対する血栓内膜摘除術とバルーン肺動脈形成術のハイブリッド治療にて良好な結果を得られた一例

  o Kinutani, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Noriaki Emoto, Nakayama Kazuhiko, Yu Taniguchi, Yuto Shinkura, Hirata Ken-ichi, Yutaka Ohkita, Okada Kenji

  ストラクチャージャパン ライブデモンストレーション2014, Nov. 2014, Japanese, ストラクチャージャパン, 東京, Domestic conference

  Oral presentation


• Balloon Pulmonary Angioplasty can be an Alternative Treatment Strategy for the Management of Non-Operable Chronic Thromboembolic Pulmonary Hypertension.

  Taniguchi Y, Miyagawa K, Nakayama Kazuhiko, Kinutani H, Shinke Toshiro, Okada Kenji, Okita Yutaka, Hirata Ken-ichi, Emoto N

  INTERNATIONAL CTEPH CONFERENCE 2014, Jun. 2014, English, International CTEPH Association, パリ, フランス, International conference

  Poster presentation


• The impact of pancreatic fistula grade C on survival after panceatic resection ；analysis of 1,015 patients with pancreatic cancer in multicenter study

  Kawai M, Murakami Y, Tani M, Hirono S, Okada Kenji, Motoi F, Unno M, Sho M, Nakajima Y, Uemura K, Satoi S, A-Hon Kwon, Matsumoto Ippei, Goto Tadahiro, Honda G, Kurata M, Yamaue H

  The Society For Surgery Of The Alimentary Tract 55th Annual Meeting (DDW2014), May 2014, English, The Society for surgery of the Alimentary Tract, Chicago, USA, International conference

  Oral presentation


• Nephrin-podocin complex as a possible regulator of spermatogenesis

  Enatsu N, Fukuda T, Okada Kenji, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  109thAUA(American Urological Association)annual meeting, May 2014, English, American Urological Association, オーランド, アメリカ, International conference

  Poster presentation


• Impact of preoperative billiary drainage on short-and long-term outcome after pancreaticoduodenectomy for cancer of the head of pancreas

  Uemura K, Murakami Y, Kawai M, Okada Kenji, Matsumoto Ippei, Asari Sadaki, Satoi S, Yanagimoto H, Sho M, Akahori T, Honda G, Kurata M, Motoi F, Unno M

  The Society For Surgery Of The Alimentary Tract 55th Annual Meeting (DDW2014), May 2014, English, The Society for surgery of the Alimentary Tract, Chicago, USA, International conference

  Oral presentation


• 腎動脈下大動脈の屈曲がEVAR後の長期成績に与える影響

  Nomura Yoshikatsu, Yamanaka Katsuhiro, 深瀬 圭吾, 井戸口 孝二, Yamaguchi Masato, Sugimoto Koji, 村上 優, 陽川 孝樹, 後竹 康子, 小原 大見, 井澤 直人, Miyahara Shunsuke, 白坂 知識, Sakamoto Toshihito, Inoue Takeshi, Matsumori Masamichi, Okada Kenji, Okita Yutaka

  第115回日本外科学会総会, 2014, Japanese, 日本外科学会, 京都, Domestic conference

  Oral presentation


• EVAR後type II endoleakに対する治療成績

  Nomura Yoshikatsu, Yamanaka Katsuhiro, 深瀬 圭吾, 後竹 康子, 小原 大見, 井澤 直人, 白坂 知識, Miyahara Shunsuke, Sakamoto Toshihito, Inoue Takeshi, Matsumori Masamichi, Yamaguchi Masato, Sugimoto Koji, Okada Kenji, Okita Yutaka

  第42回日本血管外科学会総会, 2014, Japanese, 日本血管外科学会, 青森, Domestic conference

  Oral presentation


• Clinical outcome of tricyclic antidepressants in infertile men with ejaculatory disorders.

  Enatsu N, Yamaguchi Kohei, Okada Kenji, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  9hConference of the Pacific Rim Societyfor Fertility and Sterility, Nov. 2013, English, Conference of the Pacific Rim Societyfor Fertility and Sterility, 神戸, International conference

  Poster presentation


• 慢性肺血栓塞栓症 (CTEPH)治療におけるバルーン肺動脈形成術 (BPA)の位置づけと治療手技の実際

  Shinke Toshiro, 谷口 悠, 絹谷 洋人, 宮川 一也, Takaya Tomofumi, Nakayama Kazuhiko, Otake Hiromasa, 江本 憲昭, Hirata Ken-ichi, Okada Kenji, Okita Yutaka

  日本肺高血圧学会, Oct. 2013, Japanese, 日本肺高血圧学会, 東京, Domestic conference

  Public symposium


• 慢性血栓塞栓性肺高血圧症に対する薬物治療と経皮的肺動脈バルーン形成術の治療効果の検討

  谷口 悠, Shinke Toshiro, 絹谷 洋人, 宮川 一也, Nakayama Kazuhiko, Otake Hiromasa, 江本 憲昭, Hirata Ken-ichi, Okada Kenji, Okita Yutaka

  第61回心臓病学会, Sep. 2013, Japanese, Japanese College of Cardiology, 熊本, Domestic conference

  Oral presentation


• 慢性血栓塞栓性肺高血圧症に対する 肺動脈カテーテル形成術と血栓内膜摘除術の比較

  谷口悠, 江本憲昭, 絹谷洋人, 宮川一也, Otake Hiromasa, Shinke Toshiro, Hirata Ken-ichi, Okada Kenji, Okita Yutaka

  日本心臓病学会, Sep. 2013, Japanese, 日本心臓病学会, 熊本, Domestic conference

  Oral presentation


• Comparison between Balloon Pulmonary Angioplasty and Pulmonary Thromboendarterectomy on Chronic Thromboembolic Pulmonary Hypertension

  谷口 悠, 江本 憲昭, 絹谷 洋人, Nakayama Kazuhiko, Shinke Toshiro, Okada Kenji, Okita Yutaka, Hirata Ken-ichi

  第2回日本肺循環学会学術集会, Jun. 2013, Japanese, Japanease Pulmonary Circulation Society, 東京, Domestic conference

  Oral presentation


• EVAR後type 2 endoleakに対する治療

  Nomura Yoshikatsu, 後竹 康子, 竹歳 秀人, Miyahara Shunsuke, Shirasaka Tomonori, Sakamoto Toshihito, Omura Atsushi, Inoue Takeshi, 南 一司, Okada Kenji, 宮本 直和, Yamaguchi Masato, Idoguchi Koji, Sugimoto Koji, Okita Yutaka

  The 41st Annual Meating of The Japanese Society for The Vascular Surgery, May 2013, Japanese, The Japanese Society for The Vascular Surgery, 大阪, Domestic conference

  Oral presentation


• Clusterin has a possibility to protect the injury of testicular cells induced by heat shock stress

  Matsushita Kei, Yamaguchi Kohei, Enatsu N, Fuping Li, Okada Kenji, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  108thAUA(American Urological Association)annual meeting, May 2013, English, AUA(American Urological Association)annual meeting, サンディエゴ, アメリカ, International conference

  Poster presentation


• Candesartan ameliorates cisplatin induced testicular damage and change of expression pattern of testicular podocin and nephrin

  Enatsu N, Yamaguchi Kohei, Okada Kenji, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  108thAUA(American Urological Association)annual meeting, May 2013, English, AUA(American Urological Association)annual meeting, サンディエゴ, アメリカ, International conference

  Poster presentation


• 腹部大動脈瘤に対するステントグラフト内挿術の適応拡大における問題点

  Nomura Yoshikatsu, 後竹 康子, 木下 史子, 小原 大見, 中井 秀和, Yamanaka Katsuhiro, Shirasaka Tomonori, 竹歳 秀人, Miyahara Shunsuke, Sakamoto Toshihito, Omura Atsushi, Inoue Takeshi, 南 一司, Okada Kenji, Ueshima Eisuke, Idoguchi Koji, Yamaguchi Masato, Sugimoto Koji, Okita Yutaka

  The 113rd Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, The Japan Surgical Society, 福岡, Domestic conference

  Oral presentation


• Comprehensive evaluation of androgen replacement therapy for men with late-onset hypogonadism

  Yamaguchi Kohei, Okada Kenji, Enatsu N, Fuping Li, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  14ｔｈBiennial Meeting of the Asia-Pacific Society for Sexual Medicine (APSSM), Apr. 2013, English, Biennial Meeting of the Asia-Pacific Society for Sexual Medicine (APSSM), 金沢, International conference

  Oral presentation


• Candesartan ameliorates cisplatin induced testicular damage and change of expression pattern of testicular podocin and nephrin

  Enatsu N, Yamamichi F, Okada Kenji, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  28thEAU(European Association of Urology), Mar. 2013, English, EAU(European Association of Urology), ミラノ, イタリア, International conference

  Poster presentation


• 腹部大動脈瘤の治療成績 EVAR vs Open Surgery

  Nomura Yoshikatsu, 竹歳 秀人, 小原 大見, Shirasaka Tomonori, Miyahara Shunsuke, Yamanaka Katsuhiro, Sakamoto Toshihito, Omura Atsushi, 田中 亜紀子, Inoue Takeshi, 岡 隆紀, Okada Kenji, Okita Yutaka, Yamaguchi Masato, Sugimoto Koji

  The 43rd Annual Meating of the Japanese Society for Cardiovascular Surgery, Feb. 2013, Japanese, The Japanese Society for Cardiovascular Surgery, 東京, Domestic conference

  Oral presentation


• RA-GEF-2 function in mouse spermatogenesis

  Okada Kenji

  9th International Council on Archives, Feb. 2013, English, International Council on Archives, メルボルン, International conference

  Poster presentation


• Clusterin has a possibility to protect the injury of testicular cells induced by heat shock stress

  Matsushita Kei, Yamaguchi Kohei, Enatsu N, Fuping Li, Okada Kenji, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  10th International Congress of Andrology ( ICA), Feb. 2013, English, International Congress of Andrology ( ICA), メルボルン, オーストラリア, International conference

  Poster presentation


• Barlow症候群に対する僧帽弁形成術

  南 一司, Miyahara Shunsuke, Shirasaka Tomonori, 野村拓生, Nomura Yoshikatsu, Sakamoto Toshihito, Omura Atsushi, 田中亜紀子, 宗像 宏, Inoue Takeshi, 北川敦士, Okada Kenji, Okita Yutaka

  関西胸部外科学会, Jun. 2012, Japanese, 香川大学, 香川, Domestic conference

  Oral presentation


• 胸部大動脈瘤再手術例の検討

  南 一司, 佐藤雅信, Miyahara Shunsuke, Shirasaka Tomonori, Nomura Yoshikatsu, Sakamoto Toshihito, Omura Atsushi, 田中亜紀子, 宗像 宏, Inoue Takeshi, 岡 隆紀, 北川敦士, Okada Kenji, Okita Yutaka

  日本外科学会学術総会, Apr. 2012, Japanese, 琉球大学, 沖縄, Domestic conference

  Poster presentation


• Survey of outcome and safety with oseltamivir treatment in Japanese infants under 3 months of age with influenza.

  Morioka Ichiro, Nonoyama S, Tanaka-Taya K, Ihara T, Sugaya N, Ueta I, Kumagai T, Okada Kenji, Hosoya M, Okabe N, Morishima T

  Pediatric Academic Societies Annual Meeting, Apr. 2012, English, Boston, Oseltamivir treatments at 1.5-2.0 mg/kg twice daily appear to be safe in infants with influenza less than 3 months of age and lead to positive short-term outcomes with early initiation of oseltamivir at onset of influenza., International conference

  Poster presentation


• Efficacy of androgen replacement therapy in men with hypogonadal end-stage renal disease

  Yamaguchi Kohei, Okada Kenji, Matsushita Kei, Li F, Ando M, Chiba Koji, Mityake H, Fujisawa Masato

  28th Korea-Japan Urological Congress, Sep. 2011, English, Korea-Japan Urological Congress, スウォン, 韓国, International conference

  Oral presentation


• A case with spontaneous coronary dissection which entry point was detected by frequency domain OCT.

  Masayuki Nakagawa, Junya Shite, Shinke Toshiro, Otake Hiromasa, Daisuke Matsumoto, Hiroyuki Kawamori, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yuu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hirata Ken-ichi, Hitoshi Minami, Okada Kenji, Okita Yutaka

  第20回日本心血管インターベンション治療学会, Jul. 2011, English, 日本心血管インターベンション治療学会, 大阪, Domestic conference

  Oral presentation


• 自己弁温存大動脈基部置換術後AR 再発の検討

  岡隆紀, 佐藤雅信, Miyahara Shunsuke, Sakamoto Toshihito, 野村拓生, Omura Atsushi, Nomura Yoshikatsu, 藤田靖之, 田中亜紀子, 宗像宏, Inoue Takeshi, 南一司, 北川敦士, Okada Kenji, Okita Yutaka

  第41回日本心臓血管外科学会学術総会, Feb. 2011, Japanese, 日本心臓血管外科学会, 浦安, Domestic conference

  Oral presentation


• Surgical treatment for distal aortic arch aneurysm

  Okada Kenji, Omura Atsushi, Shirasaka Tomonori, 野村拓生, Nomura Yoshikatsu, 藤田靖之, 田中亜紀子, 宗像 宏, Matsumori Masamichi, 北川敦士, 岡 隆紀, 南 一司, 長谷川智巳, Okita Yutaka

  第41回日本心臓血管外科学会学術総会, Feb. 2011, Japanese, 日本心臓血管外科学会, 東京, Domestic conference

  Public symposium


• TEVAR の急性期、遠隔期イベント発生に及ぼす危険因子の検討

  北川敦士, Okita Yutaka, Okada Kenji, 岡 隆紀, 南一司, Inoue Takeshi, 宗像宏, 田中亜希子, Yamaguchi Masato, Sugimoto Koji, Sugimura Kazuro

  第41回日本心臓血管外科学会, Feb. 2011, Japanese, 日本心臓血管外科学会, 東京, Domestic conference

  Oral presentation


• Recent Advancements of Total Arch replacement in TEVAR Era

  Okada Kenji, Omura Atsushi, Shirasaka Tomonori, 野村拓生, Nomura Yoshikatsu, 藤田靖之, 田中亜紀子, 宗像 宏, Matsumori Masamichi, 北川敦士, 岡 隆紀, 南 一司, 長谷川智巳, Okita Yutaka

  The Society of Thoracic Surgeons 47th Annual Meeting, Jan. 2011, English, The Society of Thoracic Surgeons, San Diego, International conference

  Poster presentation


• Surgical treatment for ischemic mitral regurgitation

  Okada Kenji, 吉田和則, 佐藤雅信, Miyahara Shunsuke, 野村拓生, Nomura Yoshikatsu, Sakamoto Toshihito, Omura Atsushi, 藤田靖之, 田中亜紀子, 宗像 宏, Inoue Takeshi, 岡 隆紀, 南 一司, Okita Yutaka

  第24回日本冠疾患学会学術集会, Dec. 2010, Japanese, 日本冠疾患学会, 東京, Domestic conference

  Public symposium


• 日本人大動脈弁狭窄症患者におけるカテーテル大動脈弁置換術の適合性

  北川敦士, Okita Yutaka, Okada Kenji, 岡 隆紀, 南一司, Inoue Takeshi, 宗像宏, 田中亜希子, Yamaguchi Masato, Sugimoto Koji, Sugimura Kazuro

  第63回日本胸部外科学会, Oct. 2010, Japanese, 日本胸部外科学会, 岡山, Domestic conference

  Oral presentation


• 自己弁温存大動脈基部置換術の中期遠隔成績

  岡隆紀, Shirasaka Tomonori, Sakamoto Toshihito, 野村拓生, Omura Atsushi, Nomura Yoshikatsu, 藤田靖之, 田中亜紀子, 宗像宏, 南一司, 長谷川智己, 北川敦士, Okada Kenji, Okita Yutaka

  第63回日本胸部外科学会学術総会, Oct. 2010, Japanese, 日本胸部外科学会, 大阪, Domestic conference

  Others


• Total arch replacement for shaggy aorta

  Okada Kenji, Omura Atsushi, 佐藤雅信, Miyahara Shunsuke, 野村拓生, Nomura Yoshikatsu, Sakamoto Toshihito, 藤田靖之, 田中亜紀子, Inoue Takeshi, 宗像 宏, 岡 隆紀, 南 一司, 北川敦士, Okita Yutaka

  第63回日本胸部外科学会定期学術集会, Oct. 2010, Japanese, 日本胸部外科学会, 大阪, Domestic conference

  Public symposium


• 当科における弓部大動脈再建時の脳保護法の工夫

  岡隆紀, Shirasaka Tomonori, Sakamoto Toshihito, 野村拓生, Omura Atsushi, Nomura Yoshikatsu, 藤田靖之, 田中亜紀子, 宗像宏, Matsumori Masamichi, 南一司, 長谷川智己, 北川敦士, Okada Kenji, Okita Yutaka

  第53回関西胸部外科学会学術総会, Jun. 2010, Japanese, 日本胸部外科学会, 名古屋, Domestic conference

  Oral presentation


• 重症心不全に対する外科治療の中長期成績

  南 一司, Shirasaka Tomonori, 野村拓生, Nomura Yoshikatsu, Sakamoto Toshihito, Omura Atsushi, 田中亜紀子, 宗像 宏, Matsumori Masamichi, 岡 隆紀, 北川敦士, Okada Kenji, Okita Yutaka

  関西胸部外科学会, Jun. 2010, Japanese, 安藤太三, 名古屋, Domestic conference

  Oral presentation


• 広範囲胸部大動脈瘤に対するハイブリッド手術の問題点

  北川敦士, Okita Yutaka, Okada Kenji, 長谷川智巳, Matsumori Masamichi, 南一司, 宗像宏, 田中亜希子, Yamaguchi Masato, Sugimoto Koji, Sugimura Kazuro

  第53回関西胸部外科学会, Jun. 2010, Japanese, 関西胸部外科学会, 名古屋, Domestic conference

  Public symposium


• 自己弁温存大動脈基部置換術の遠隔成績

  岡隆紀, Shirasaka Tomonori, Sakamoto Toshihito, 野村拓生, Omura Atsushi, Nomura Yoshikatsu, 藤田靖之, 田中亜紀子, 宗像宏, Matsumori Masamichi, 南一司, 長谷川智己, 北川敦士, Okada Kenji, Okita Yutaka

  第38回日本血管外科学会学術総会, May 2010, Japanese, 日本血管外科学会, 大宮, Domestic conference

  Public symposium


• Outcome of Total Aortic Arch Replacement with Coronary Artery Disease

  Okada Kenji, Omura Atsushi, Shirasaka Tomonori, 野村拓生, Nomura Yoshikatsu, 藤田靖之, 田中亜紀子, 宗像 宏, Matsumori Masamichi, 北川敦士, 岡 隆紀, 南 一司, 長谷川智巳, Okita Yutaka

  第38回日本血管外科学会学術総会, May 2010, Japanese, 日本血管外科学会, 大宮, Domestic conference

  Public symposium


• Long-term outcome in CABG: bilateral or single use of IMA

  Okada Kenji, Omura Atsushi, Shirasaka Tomonori, 野村拓生, Nomura Yoshikatsu, Sakamoto Toshihito, 藤田靖之, 田中亜紀子, 宗像 宏, Matsumori Masamichi, 岡 隆紀, 南 一司, 北川敦士, 長谷川智己, Okita Yutaka

  第112回外科学会定期学術集会, Apr. 2010, Japanese, 日本外科学会, 名古屋, Domestic conference

  Oral presentation


• Activation of transglutaminase type 2 for aortic wall protection in a rat abdominal aortic aneurysm formation.

  長谷川智巳, 宗実 孝, 田中亜紀子, 蘇日他拉, Okada Kenji, Okita Yutaka

  第110回外科学会定期学術集会, Apr. 2010, Japanese, 日本外科学会, 名古屋, Domestic conference

  Oral presentation


• 自己弁温存大動脈基部置換術再手術症例の検討

  岡隆紀, Shirasaka Tomonori, Sakamoto Toshihito, 野村拓生, Omura Atsushi, Nomura Yoshikatsu, 藤田靖之, 田中亜紀子, 宗像宏, Matsumori Masamichi, 南一司, 長谷川智己, 北川敦士, Okada Kenji, Okita Yutaka

  第110回日本外科学会学術集会, Apr. 2010, Japanese, 日本外科学会, 名古屋, Domestic conference

  Oral presentation


• 高齢者弁膜症手術の成績と問題点

  南 一司, Shirasaka Tomonori, 野村拓生, Nomura Yoshikatsu, Sakamoto Toshihito, Omura Atsushi, 田中亜紀子, 宗像 宏, Matsumori Masamichi, 長谷川智巳, 北川敦士, Okada Kenji, Okita Yutaka

  日本外科学会学術総会, Apr. 2010, Japanese, 中尾昭公, 名古屋, Domestic conference

  Oral presentation


• Pioglitazone preserves vein graft integrity in a rat aortic interposition model.

  陳 志, 長谷川智巳, 田中亜紀子, Okada Kenji, Okita Yutaka

  第111回外科学会定期学術集会, Apr. 2010, Japanese, 日本外科学会, 名古屋, Domestic conference

  Oral presentation


• TEVARの適応と限界 Shaggy aortaはcontraindicationか?

  北川敦士, Okita Yutaka, Okada Kenji, 長谷川智巳, Matsumori Masamichi, 南一司, 宗像宏, 田中亜希子, Yamaguchi Masato, Sugimoto Koji, Sugimura Kazuro

  第110回日本外科学会, Apr. 2010, Japanese, 日本外科学会, 名古屋, Domestic conference

  Oral presentation


• 当院における80歳以上高齢者の心臓大血管手術の検討－正確なリスクファクターの把握－

  Hasegawa Tomoki, Omura Atsushi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Fujita Yasuyuki, Tanaka Akiko, Munakata Hiroshi, Matsumori Masamichi, Oka Takanori, Minami Hitoshi, Okada Kenji, Okita Yutaka

  日本心臓血管外科学会, Feb. 2010, Japanese, 日本心臓血管外科学会, 神戸, Domestic conference

  Oral presentation


• 大動脈弁形成術は標準治療となりうるか？

  Matsumori Masamichi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Oka Takanori, Minami Hitoshi, Hasegawa Tomoki, Okada Kenji, Okita Yutaka

  第41回日本心臓血管外科学会総会, Feb. 2010, Japanese, 日本心臓血管外科学会, 神戸, Domestic conference

  Public symposium


• 大動脈基部手術: valve sparing vs. Bentall procedure

  Matsumori Masamichi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Oka Takanori, Minami Hitoshi, Hasegawa Tomoki, Okada Kenji, Okita Yutaka

  第40回日本心臓血管外科学会総会, Feb. 2010, Japanese, 日本心臓血管外科学会, 神戸, Domestic conference

  [Invited]

  Invited oral presentation


• 急性大動脈解離における臓器灌流障害合併症例の検討

  Munakata Hiroshi, Omura Atsushi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Fujita Yasuyuki, Tanaka Akiko, Matsumori Masamichi, Oka Takanori, Minami Hitoshi, Hasegawa Tomoki, Kitagawa Atsushi, Okada Kenji, Okita Yutaka

  第40回日本心臓血管外科学会学術総会, Feb. 2010, Japanese, 日本心臓血管外科学会, 神戸, Domestic conference

  Poster presentation


• Outcomes of surgical intervention for active infective endocarditis

  Minami Hitoshi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Okada Kenji, Okita Yutaka

  日本心臓血管外科学会総会, Feb. 2010, Japanese, 日本心臓血管外科学会, 神戸, Domestic conference

  Oral presentation


• Which Conduit Is Better For Aortic Infection Disease ? Dacron graft

  Munakata Hiroshi, Shirasaka Tomonori, Nomura Yoshikatsu, Omura Atsushi, Sakamoto Toshihito, Fujita Yasuyuki, Tanaka Akiko, Matsumori Masamichi, Oka Takanori, Minami Hitoshi, Okada Kenji, Okita Yutaka

  第40回日本心臓血管外科学会学術総会, Feb. 2010, Japanese, 日本心臓血管外科学会, 神戸, Domestic conference

  [Invited]

  Invited oral presentation


• Standardized surgical procedure of total arch replacement in TEVAR era

  Okada Kenji, Omura Atsushi, Shirasaka Tomonori, Nomura Yoshikatsu, Sakamoto Toshihito, Fujita Yasuyuki, Tanaka Akiko, Munakata Hiroshi, Matsumori Masamichi, Oka Takanori, Minami Hitoshi, Kitagawa Atsushi, Okita Yutaka

  第40回日本心臓血管外科学会学術総会, Feb. 2010, Japanese, 日本心臓血管外科学会, 神戸, Domestic conference

  Public symposium


• 自作ステントグラフトによるTEVARの遠隔成績

  Kitagawa Atsushi, Tanaka Akiko, Munakata Hiroshi, Matsumori Masamichi, Minami Hitoshi, Hasegawa Tomoki, Okada Kenji, Yamaguchi Masato, Sugimoto Koji, Sugimura Kazuro, Okita Yutaka

  第47回日本人工臓器学会総会, Nov. 2009, Japanese, 日本人工臓器学会, 新潟, Domestic conference

  Public symposium


• Aortic root replacement with annular reconstruction for destructive aortic root abscess

  Okada Kenji

  平成21年度阪神心臓弁膜症シンポジウム, Oct. 2009, Japanese, 阪神心臓弁膜症シンポジウム, 西宮, Domestic conference

  Others


• Mitral valve repair for bileaflets prolapse and complex leision

  Minami Hitoshi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Okada Kenji, Okita Yutaka

  日本胸部外科学会総会, Oct. 2009, Japanese, 日本胸部外科学会, 仙台, Domestic conference

  Poster presentation


• The Relation Between The Intracranial Arteries And The Postoperative Brain Low-Perfusion Damage After Total Arch Replacement

  Munakata Hiroshi, Shirasaka Tomonori, Nomura Yoshikatsu, Sakamoto Toshihito, Tanaka Akiko, Matsumori Masamichi, Minami Hitoshi, Okada Kenji, Okita Yutaka

  第62回日本胸部外科学会学術総会, Oct. 2009, Japanese, 日本胸部外科学会, 横浜, Domestic conference

  Oral presentation


• Shaggy aorta症例に対するTEVAR---SMA閉塞バルーンの有用性

  Kitagawa Atsushi, Okita Yutaka, Okada Kenji, Hasegawa Tomoki, Minami Hitoshi, Matsumori Masamichi, Munakata Hiroshi, Tanaka Akiko, Nomura Yoshikatsu, Yamaguchi Masato, Sugimoto Koji, Sugimura Kazuro

  第62回日本胸部外科学会総会, Oct. 2009, Japanese, 日本胸部外科学会, 横浜, Domestic conference

  Oral presentation


• Midterm result of aortic cusp repair

  Matsumori Masamichi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Oka Takanori, Minami Hitoshi, Hasegawa Tomoki, Okada Kenji, Okita Yutaka

  第62回日本胸部外科学会総会, Oct. 2009, Japanese, 日本胸部外科学会, 横浜, Domestic conference

  Oral presentation


• Coronary artery bypass grafting in patients with impaired the left ventricle

  Okada Kenji, Omura Atsushi, Shirasaka Tomonori, Nomura Yoshikatsu, Sakamoto Toshihito, Tanaka Akiko, Munakata Hiroshi, Matsumori Masamichi, Minami Hitoshi, Hasegawa Tomoki, Okita Yutaka

  第62回日本胸部外科学会定期学術総会, Sep. 2009, Japanese, 日本胸部外科学会, 横浜, Domestic conference

  Oral presentation


• Standardized aortic surgery in TEVAR era

  Okada Kenji, Omura Atsushi, Munakata Hiroshi, Matsumori Masamichi, Kitagawa Atsushi, Okita Yutaka

  第57回日本心臓病学会学術集会, Sep. 2009, Japanese, 日本心臓病学会, 札幌, Domestic conference

  [Invited]

  Invited oral presentation


• Open Surgical Repair for Failed Thoracic Endovascular Repair

  Tanaka Akiko, Kitagawa Atsushi, Matsumori Masamichi, Okada Kenji, Okita Yutaka

  European Society of Vascular Surgery, Sep. 2009, English, European Society of Vascular Surgery, オスロ, ノルウェー, International conference

  Poster presentation


• Valve sparing aortic root replacement with aortic valve cusp repai for congenital bicuspid aortic valve

  Okada Kenji, Matsumori Masamichi, Okita Yutaka

  第20回関西心臓手術手技研究会, Jul. 2009, Japanese, CSLベーリング株式会社, 大阪, Domestic conference

  [Invited]

  Invited oral presentation


• 追加治療を要したTEVAR症例の検討

  Kitagawa Atsushi, Okita Yutaka, Okada Kenji, Hasegawa Tomoki, Minami Hitoshi, Matsumori Masamichi, Munakata Hiroshi, Tanaka Akiko, Nomura Yoshikatsu, Yamaguchi Masato, Sugimoto Koji, Sugimura Kazuro

  第52回関西胸部外科学会, Jun. 2009, Japanese, 関西胸部外科学会, 岡山, Domestic conference

  Oral presentation


• 成人期に施行された先天的大血管異常の手術成績

  Munakata Hiroshi, Omura Atsushi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Fujita Yasuyuki, Tanaka Akiko, Matsumori Masamichi, Oka Takanori, Minami Hitoshi, Hasegawa Tomoki, Kitagawa Atsushi, Okada Kenji, Okita Yutaka

  第52回関西胸部外科学会学術総会, Jun. 2009, Japanese, 関西胸部外科学会, 岡山, Domestic conference

  Oral presentation


• Long term results of surgery for ischemic mitral regurgitation

  Minami Hitoshi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Okada Kenji, Okita Yutaka

  関西胸部外科学会, Jun. 2009, Japanese, 関西胸部外科学会, 岡山, Domestic conference

  Oral presentation


• Marfan症候群に対する胸腹部大動脈瘤の治療戦略

  Matsumori Masamichi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Oka Takanori, Minami Hitoshi, Hasegawa Tomoki, Okada Kenji, Okita Yutaka

  第52回関西胸部外科学会, Jun. 2009, Japanese, 日本胸部外科学会, 岡山, Domestic conference

  Public symposium


• Does aortic cusp repair influence the outcome of Valve sparing aortic root replacement ?

  Matsumori Masamichi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Oka Takanori, Minami Hitoshi, Hasegawa Tomoki, Okada Kenji, Okita Yutaka

  society of heart valve disease, Jun. 2009, English, The Society for Heart Valve Disease, ベルリン, ドイツ, International conference

  Poster presentation


• Choradal Preservation in Patients with Mitral Stenosis Undergoing Mitral Valve Replacement

  Tanaka Akiko, Matsumori Masamichi, Okada Kenji, Okita Yutaka

  Society of Heart Valve Disease, Jun. 2009, English, Society of Heart Valve Disease, ベルリン, ドイツ, International conference

  Poster presentation


• Balloon protection of superior mesenteric artery to prevent mesenteric ischemia during TEVAR for shaggy aorta

  Kitagawa Atsushi, Okita Yutaka, Okada Kenji, Hasegawa Tomoki, Minami Kotaro, Munakata Hiroshi, Tanaka Akiko, Nomura Yoshikatsu, Yamaguchi Masato, Sugimoto Koji, Sugimura Kazuro

  The 10th Multidisciplinary European Endovascular Therapy, Jun. 2009, English, Multidisciplinary European Endovascular Therapy, カンヌ, フランス, International conference

  Oral presentation


• Aortic arch repair for the patients with renal insufficiency

  Minami Hitoshi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Okada Kenji, Okita Yutaka

  日本血管外科学会総会, May 2009, Japanese, 日本血管外科学会, 名古屋, Domestic conference

  Poster presentation


• 急性B型大動脈解離遠隔期の成績

  Munakata Hiroshi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Omura Atsushi, Tanaka Akiko, Matsumori Masamichi, Kitagawa Atsushi, Hasegawa Tomoki, Okada Kenji, Okita Yutaka

  第34回日本血管外科学会学術総会, May 2009, Japanese, 日本血管外科学会, 名古屋, Domestic conference

  Oral presentation


• Surgical outcome of patients with renal cell carcinoma extending to the inferior vena cava

  Okada Kenji, Shirasaka Tomonori, Sakamoto Toshihito, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Matsumori Masamichi, Minami Hitoshi, Hasegawa Tomoki, Okita Yutaka

  第37回日本血管外科学会総会, May 2009, Japanese, 日本血管外科学会, 名古屋, Domestic conference

  Oral presentation


• 炎症性大動脈疾患に対する大動脈基部置換術の検討

  Matsumori Masamichi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Oka Takanori, Minami Hitoshi, Hasegawa Tomoki, Okada Kenji, Okita Yutaka

  第37回日本血管外科学会総会, May 2009, Japanese, 日本血管外科学会, 名古屋, Domestic conference

  Oral presentation


• エラスターゼ/塩化カルシウム併用による新しいラット腹部大動脈モデルの開発

  Hasegawa Tomoki, Tanaka Akiko, Okada Kenji, Okita Yutaka

  日本血管外科学会, May 2009, Japanese, 日本血管外科学会, 名古屋, Domestic conference

  Oral presentation


• EVAR --- Is it available for most of Japanese AAA patients?

  Kitagawa Atsushi, Okita Yutaka, Okada Kenji, Hasegawa Tomoki, Minami Kotaro, Matsumori Masamichi, Nomura Yoshikatsu, Yamaguchi Masato, Sugimoto Koji, Sugimura Kazuro

  第36 回日本血管外科学会総会, May 2009, English, 日本血管外科学会, 名古屋, Domestic conference

  Oral presentation


• Re-do valve surgery complicated by destroyed annulus

  Okada Kenji, Shirasaka Tomonori, Sakamoto Toshihito, Tanaka Akiko, Munakata Hiroshi, Matsumori Masamichi, Okita Yutaka

  第109回日本外科学会定期学術総会, Apr. 2009, Japanese, 日本外科学会, 福岡, Domestic conference

  Public symposium


• Aortic root replacement with autologous pericardial patch annuloplasty for destructive root abscess

  Okada Kenji, Shirasaka Tomonori, Sakamoto Toshihito, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Matsumori Masamichi, Hasegawa Tomoki, Okita Yutaka

  第39回日本心臓血管外科学会学術総会, Apr. 2009, Japanese, 日本心臓血管外科学会学, 富山, Domestic conference

  Oral presentation


• 神戸大学病院における弓部大動脈瘤手術のスタンダード

  Hasegawa Tomoki, Shirasaka Tomonori, Sakamoto Toshihito, Omura Atsushi, Nomura Yoshikatsu, Tanaka Akiko, Munakata Hiroshi, Matsumori Masamichi, Okada Kenji, Okita Yutaka

  日本外科学会, Apr. 2009, Japanese, 日本外科学会, 福岡, Domestic conference

  Oral presentation


• 自己弁温存大動脈基部置換術の遠隔成績に及ぼす大動脈基部径の影響

  Matsumori Masamichi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Oka Takanori, Minami Hitoshi, Hasegawa Tomoki, Okada Kenji, Okita Yutaka

  第109回日本外科学会定期学術集会, Apr. 2009, Japanese, 日本外科学会, 福岡, Domestic conference

  Oral presentation


• 胸部大動脈破裂に対する検討： TEVAR vs open surgery

  Kitagawa Atsushi, Okita Yutaka, Okada Kenji, Hasegawa Tomoki, Minami Hitoshi, Matsumori Masamichi, Munakata Hiroshi, Tanaka Akiko, Nomura Yoshikatsu, Yamaguchi Masato, Sugimoto Koji, Sugimura Kazuro

  第61回日本外科学会総会, Apr. 2009, Japanese, 日本外科学会, 福岡, Domestic conference

  Public symposium


• 胸部下行大動脈破裂：TEVAR とopen surgery の比較と問題点

  Kitagawa Atsushi, Okita Yutaka, Okada Kenji, Hasegawa Tomoki, Minami Hitoshi, Matsumori Masamichi, Munakata Hiroshi, Tanaka Akiko, Nomura Yoshikatsu, Yamaguchi Masato, Sugimoto Koji, Sugimura Kazuro

  第39回日本心臓血管外科学会総会, Apr. 2009, Japanese, 日本心臓血管外科学会, 富山, Domestic conference

  Public symposium


• 急性B型大動脈解離に対する遠隔期保存的加療の限界

  Munakata Hiroshi, Shirasaka Tomonori, Sakamoto Toshihito, Nomura Yoshikatsu, Omura Atsushi, Tanaka Akiko, Matsumori Masamichi, Kitagawa Atsushi, Hasegawa Tomoki, Okada Kenji, Okita Yutaka

  第39回日本心臓血管外科学会学術総会, Apr. 2009, Japanese, 日本心臓血管外科学会, 富山, Domestic conference

  Oral presentation


• Mid-term result of aortic root replacement： Valve sparing vs Bentall

  Matsumori Masamichi, Sakamoto Toshihito, Nomura Yoshikatsu, Omura Atsushi, Tanaka Akiko, Munakata Hiroshi, Oka Takanori, Minami Hitoshi, Hasegawa Tomoki, Okada Kenji, Okita Yutaka

  第39回日本心臓血管外科学会総会, Apr. 2009, Japanese, 日本心臓血管外科学会, 富山, Domestic conference

  Oral presentation


• Comparative analysis of ruptured descending thoracic aortic aneurysms between TEVAR and open surgery

  Kitagawa Atsushi, Sugimoto Koji, Yamaguchi Masato, Okada Kenji, Okita Yutaka

  The 21th International Symposium on Endovascular Surgery, Jan. 2009, English, International Society of Endovascular Surgery, ハリウッド, アメリカ, International conference

  Poster presentation


• 肺動脈血栓内膜摘除術が奏功した若年発症の慢性肺動脈血栓塞栓症の一例

  Yamashita Tomoya, Yoshida Akihiro, Emoto Noriaki, Kawai Hiroya, Shite Junya, Hirata Kenichi, Yokoyama Mitsuhiro, Matsumori Masamichi, Okada Kenji, Okita Yutaka

  第103回日本日本循環器学会近畿地方会, Jun. 2007, Japanese, 日本循環器学会, 大阪, Domestic conference

  Oral presentation


• 下大静脈内腫瘍塞栓を合併した腎悪性腫瘍に対する治療成績の検討

  Nakagiri Keitaro, Tanaka Akiko, Munakata Hiroshi, Matsumori Masamichi, Asano Mitsuru, Tanaka Hiroshi, Kawanishi Yujiro, Kitagawa Atsushi, Okada Kenji, Okita Yutaka, Fujisawa Masato

  第35回日本血管外科学会, May 2007, Japanese, 日本血管外科学会, 名古屋, Domestic conference

  Oral presentation


• 著明な接合不全を伴う重症僧帽弁閉鎖不全症に対して僧帽弁輪形成術を施行した1例

  辰巳 和宏, KAWAI, Hiroya, 溝口 貴裕, 田中 秀和, 大西 哲存, 片岡 俊哉, YOKOYAMA, Mitsuhiro, OKADA, Kenji, OKITA, Yutaka

  日本心エコー図学会学術集会（第16回）, Apr. 2005, Japanese, 日本心エコー図学会, 神戸, Domestic conference

  Oral presentation


• 一過性に僧帽弁の可動制限による著明な接合不全を来たした重症僧帽弁閉鎖不全症に対して僧帽弁輪形成術を施行した1例

  辰巳 和宏, KAWAI, Hiroya, 溝口 貴裕, 田中 秀和, 大西 哲存, 片岡 俊哉, YOKOYAMA, Mitsuhiro, OKADA, Kenji, OKITA, Yutaka

  第29回日本超音波医学会関西地方会学術集会, Feb. 2005, Japanese, 日本超音波医学会, 神戸, Domestic conference

  Oral presentation


• 一過性に僧帽弁の可動制限による著明な接合不全を来たした重症僧帽弁閉鎖不全症に対して僧帽弁輪形成術を施行した1例

  辰巳 和宏, KAWAI, Hiroya, 溝口 貴裕, 田中 秀和, 大西 哲存, 片岡 俊哉, YOKOYAMA, Mitsuhiro, OKADA, Kenji, OKITA, Yutaka

  第2回先進心血管エコー研究会, Aug. 2004, Japanese, 大阪, Domestic conference

  Oral presentation

• European Association for Cardio-Thoracic Surgery


• 日本人工臓器学会


• 日本冠疾患学会


• 日本血管外科学会


• 日本冠動脈外科学会


• 日本循環器学会


• 日本心臓血管外科学会


• 日本胸部外科学会


• 日本外科学会

• Development of novel immune therapy against abdominal aortic aneurysm.

  江本 拓央, 井上 大志, 山中 勝弘, 岡田 健次, 山下 智也

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2024 - 31 Mar. 2027


• Clarifying the mechanisms of atherosclerotic cardiovascular diseases via genome and single cell integrated omics analyses.

  平田 健一, 井上 大志, 大竹 寛雅, 山中 勝弘, 江本 拓央, 岡田 健次, 山下 智也

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2023 - 31 Mar. 2026

  本研究の目的は、動脈硬化性疾患（冠動脈疾患CAD、大動脈瘤AA、大動脈弁狭窄症AS）のシングルセルアトラスの作成と全ゲノム解析を行い、トランスオミックス統合解析を行うことで、それぞれの疾患の相違点を炙り出し、疾患のリスク層別化を行い、発症メカニズムを解明することである。本研究では、これら3疾患について、1）病変部のシングルセル＋核RNAシークエンス（scRNAseq+snRNAseq）からシングルセルアトラスを作成、各々の疾患特異的マクロファージの同定を行うと同時に、2）T細胞レパトア解析から各々の疾患において、特徴的な抗原が存在するのかを明らかにする。さらには、3）Genotyping of Transcriptomes (GoT)による シングルセルレベルで骨髄のクローン性造血の関与を調べる解析と4）全ゲノム解析による遺伝素因とトランスクリプトームの関連を解析する、expression quantitative locus (eQTL)解析を行う。3)と4)の実施にて、ゲノム・トランスクリプトーム統合解析が達成できる。すでに、3疾患の少数サンプルでのシングルセルトランスクリプトーム解析は終了し、シングルセルアトラスの概要は見えてきている。CADでT細胞受容体レパトア解析が終了し論文報告を行った。AAでは、結果を受けマウスでの実験も同時実施しており、マクロファージやB細胞での疾患特異的な特徴のデータを得ている。ASでのクローン性造血(CH)の原因となる体細胞遺伝子変異の解析数を増加させており、少数患者でのGoT解析を進めている。まずは3)GoTの統合解析手法の確立を目指す。全ゲノム解析は実施できておらず、4)eQTLの実施までには、さらに時間が必要と考えられる。


• ヒト大動脈解離におけるシングルセルRNAシークエンスによる成因解析

  岡田 健次, 井上 大志, 山中 勝弘, 江本 拓央, 山下 智也

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2022 - 31 Mar. 2025


• 大動脈解離の発生と進展に好中球が与える影響の検討

  井上 大志, 山中 勝弘, 江本 拓央, 岡田 健次, 山下 智也

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2022 - 31 Mar. 2025


• 胸腹部大動脈術後脊髄再灌流障害の新たな細胞障害機序の解明と治療法の開発

  中井 秀和, 藤田 靖之, 山中 勝弘, 世古 義規, 川本 篤彦, 岡田 健次

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2021 - 31 Mar. 2024


• To identify the biomarker in cerebrospinal fluid to prevent the spinal cord ischemia reperfusion injury

  Yamanaka Katsuhiro

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2019 - 31 Mar. 2022

  We was not able to establish the mouse model of spinal cord ischemia-reperfusion.


• Construction of human myocardial tissue using biosheet consisting of completely self-tissue

  Wada Yuko

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Shinshu University, 01 Apr. 2018 - 31 Mar. 2021

  The purpose of this study was to show that biosheets made using in-body-tissue- architecture (IBTA) can be a new filling material for dysfunctional myocardium. First, a new left ventricular pressure-loaded ectopic heart transplant model was established, and then left ventricular wall replacement with a biosheets was performed using this model. It was shown that this biosheets has sufficient strength and flexibility to withstand anastomosis and sufficient thickness and strength to withstand left ventricular filling pressure. Cardiomyocyte infiltration was not occurred and electrical coupling with the host myocardium became the next issue, but we were able to obtain results that will lead to the future.


• Basic research on anti-infective properties of biotube

  Okada Kenji

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Shinshu University, 01 Apr. 2018 - 31 Mar. 2021

  The purpose of this study was to demonstrate the anti-infection property of biotubes by infection experiments. The biotubes are completely autologous in vivo tissue-engineered connective tissue tubes. Biotubes do not contain any artificial materials and are expected to be anti-infective. If the anti-infection property is demonstrated, it will be an important study for clinical application against infection. A model was created in which biotubes and artificial blood vessels were implanted into the abdominal aorta of rats. Staphylococcus aureus was implanted in those groups, but it was difficult to control the amount of Staphylococcus aureus.The results did not support the expected anti-infection properties of the biotubes.


• Pharmaceutical treatment for abdominal aortic aneurysms in rats

  OKADA Kenji, OKITA Yutaka

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2012 - 31 Mar. 2015, Principal investigator

  An ideal pharmaceutical treatment for abdominal aortic aneurysm (AAA) is to prevent aneurysm formation and development (further dilatation of pre-existing aneurysm). Recent studies have reported that oxidative stress with reactive oxygen species (ROS) is crucial in aneurysm formation. We have demonstrated that edaravone, a free-radical scavenger, attenuated vascular oxidative stress and inhibit AAA formation and development in rat AAA model. Based on the results, we also have proven the efficacy of other anti-oxidants, such as a gelatin hydrogel sheet incorporating ascorbic acid, a novel oral antidiabetic drug of Dipeptidyl peptidase-4 (DPP-4) inhibitor, and oral administration of riboflavin on the treatment of AAA.

  Competitive research funding


• Pioglitazone prevented the neointimal hyperplasia at the site of anastomosis

  OKADA Kenji, OKITA Yutaka

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 2008 - 2010, Principal investigator

  Small caliber (〓2mm) prosthetic graft for coronary artery bypass grafting has not been developed for clinical use. The major cause of sticking point is the neointimal hyperplasia at the site of anastomosis. In the current study, we used a rat aortic interposition model with autologous femoral vein. Oral dose of Pioglitazone successfully prevented graft degeneration including the neointimal hyperplasia at the anastomosis. We are now under investigation for the prevention of neointimal hyperplasia at the anastomosis of small-caliber vascular prosthesis.

  Competitive research funding


• Research of "Autologous fibrin coated small caliber vascular prostheses improve the antithrombogenicity by less immunological response"

  OKADA Kenji, OKITA Yutaka

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 2003 - 2004

  Introduction : Development of small caliber vascular prostheses is still challenging. Recently we have developed a new technique of fibrin coatings for vascular grafts. We hypothesized that autologous fibrin coatings could improve the antithrombogenicity of grafts by less immunological response. We also examine the graft healing characteristics after implantation. Methods : Knitted polyester fabric vascular prostheses, 2mm in internal diameter, were coated with autologous (rabbit, A-graft) or xenologous (human, X-graft) fibrin by modified ethanol method from plasma. Fifty Japanese white rabbits were implanted with the grafts in bilateral carotid arteries and divided into three groups by the selection of grafts in the individual rabbit : A&X-grafts (group I, n40), A&A-grafts (group II, n=5), X&X-grafts (group III, n=5). To evaluate graft patency, anti-graft serum antibody, ^<111>Indium platelet scintigraphy and histology, the grafts in group I were explanted on postoperative days (PODs) 1, 3, 7, 10, 14, 30, 60, 180 (n=5 for each). Serum levels of immunoglobulin G (IgG) and M (IgM), tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) in group II and III were measured serially to compare immunological, coagulative and fibrinolytic reactions. Rsults : All of grafts except one X-graft on POD 10 were patent without stenosis and thrombus. Monolayer endothelial-like cells were covered on the entire surface of the A-grafts on POD 60. In group I, the maximal anti-graft serum antibodies (0.17±0.02 optical density at 490 nm [O.D.]) and the maximal platelet deposition (10.3±1.6x10^6/mm^2) in A-grafts were significantly less than those in X-grafts (0.46±0.06 O.D. and 17.4±1.4x10^6/mm^2, respectively ; p<0.0001 in both). Although serum levels of IgG, IgM, tPA and PAI-1 were increased at the time of fibrin degradation of grafts during POD 7 to 14, those in group II were significantly less than those in group III (p<0.O1, ANOVA). The PAI-1/tPA ratio in both groups was decreased as platelet deposition of the grafts was increased. Conclusion : These findings suggest that autologous fibrin coatings improve the antithrombogenicity by less immunological response and have a potential use for hybrid small caliber vascular prostheses.