Research activity information

• Dec. 2023 日本プロセス化学会, 2023 JSPC優秀賞, 医薬品製造プロセスにおける濃縮・溶媒交換への膜分離技術の適用

  熊谷和夫, Ralph Rolly Gonzales, 黒田貴一, 森田悠司, 間中敦史, 村瀬辰史, 田中洋明, 田中雅巳, 勝川幹基, 松山秀人


• Apr. 2017 The 5th Asian Graduate Student Symposium on Membrane Engineering, The Best Student Oral Presentation Award at AGSM5, Characterization of separation function of Amphotericin B for biomimetic water purification membrane

  Toru Takai, Daisuke Saeki, Kazuo Kumagai, Hideto Matsuyama

  International society

• Optimization of OARO-RO hybrid systems for the ammonium nitrogen recovery for wastewater treatment using an explainable machine learning

  Xiao Xu, Jian Zhang, Chuang Li, Zhaohuan Mai, Liheng Dai, Erda Deng, Kecheng Guan, Pengfei Zhang, Kazuo Kumagai, Susumu Hasegawa, Yuqing Lin, Keizo Nakagawa, Tomohisa Yoshioka, Hideto Matsuyama

  Elsevier BV, Sep. 2026, Desalination, 634, 120311 - 120311

  [Refereed]

  Scientific journal


• Selective concentration of sewage by forward osmosis for methane fermentation

  Yasunao Okamoto, Haruto Morishita, Atsushi Matsuoka, Ralph Rolly Gonzales, Susumu Hasegawa, Gen Yoshida, Kazuo Kumagai, Eiji Kamio, Tooru Kitagawa, Tomohisa Yoshioka, Keizo Nakagawa, Hideto Matsuyama

  Elsevier BV, Jan. 2026, Journal of Water Process Engineering, 81, 109193 - 109193

  [Refereed]

  Scientific journal


• Evaluation of simultaneous recovery of NH4+_N and high-purity water from wastewaters by OARO-RO

  Xiao Xu, Keizo Nakagawa, Kazuo Kumagai, Xueru Yan, Zhaohuan Mai, Susumu Hasegawa, Tomohisa Yoshioka, Hideto Matsuyama

  Elsevier BV, Jan. 2026, Journal of Membrane Science, 738, 124867 - 124867

  [Refereed]

  Scientific journal


• Concentration of high boiling point organic solvents by osmotically assisted reverse osmosis

  Mengyang Hu, Kazuo Kumagai, Yasushi Mino, Kecheng Guan, Toshiyuki Kawashima, Hideto Matsuyama

  Aug. 2025, Water Research, English

  [Refereed]

  Scientific journal


• Antimicrobial and antiviral activities and reaction mechanisms of an organic photocatalyst upon visible-light irradiation

  Hayato Shiroma, Atsushi Chikamoto, Masanori Kameoka, Kazuo Kumagai, Hideto Matsuyama, Yuichi Ichihashi

  Abstract Organic photocatalyst 9,10-dicyanoanthracene (CN-anthracene) has been demonstrated to exhibit antimicrobial activity upon visible-light irradiation. By evaluating these dependencies, this research aims to clarify the underlying mechanisms of its photocatalytic action and provide insights into its practical applications in diverse antimicrobial scenarios. This study examined the light and temperature dependence of the antimicrobial activity of CN-anthracene to further investigate its photocatalytic properties in detail. The antimicrobial activity was evaluated using the colony count method with Escherichia coli (E. coli) as the target organism. The results indicated that the antimicrobial rate increased with the light intensity and that the antimicrobial activity was above a certain level regardless of the temperature in the expected indoor temperature range. The antiviral activity of the photocatalyst was investigated using a median tissue culture infectious dose (TCID50) assay. The results showed that the photocatalyst exhibited high viral activity against both enveloped and non-enveloped viruses. Furthermore, the presence of reactive oxygen species (·OH and · $${\text{O } }_{ { 2 } }^{ - }$$ O 2 - ), which are believed to play a critical role in the observed antibacterial and antiviral activities, was confirmed. These findings demonstrate that CN-anthracene exhibits high antibacterial and antiviral activities under visible light, highlighting its potential as a novel tool for combating infectious diseases.

  May 2025, Research on Chemical Intermediates, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Efficient and high-density immobilization of animal cells by a microfiber with both swelling and cell adhesion properties and its application to exosome production

  Naofumi Shiomi, Pengfei Zhang, Shuji Nakatsuka, Kazuo Kumagai, Hideto Matsuyama

  Apr. 2025, Biotechnology Letters

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Treatment of high-strength wastewater with coupled flocculation and membrane filtration prior to ammoniacal nitrogen enrichment by osmotically assisted reverse osmosis

  Ralph Rolly Gonzales, Keizo Nakagawa, Susumu Hasegawa, Kazuo Kumagai, Atsushi Matsuoka, Yasunao Okamoto, Zhan Li, Zhaohuan Mai, Tomohisa Yoshioka, Tomoyuki Hori, Hideto Matsuyama

  Elsevier BV, Jan. 2025, Separation and Purification Technology, 352, 128159 - 128159

  [Refereed]

  Scientific journal


• Utilization of Okara as a Culture Medium by Membrane Concentration Process for High Oil Production by Oleaginous Yeast, Lipomyces starkeyi

  Hiroya Taki, Kentaro Mine, Mana Miyamoto, Jiro Seto, Shinji Matsuo, Kazuo Kumagai, Hideto Matsuyama

  In the original publication [...]

  Dec. 2024, Fermentation, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Establishment of an artificial urine model in vitro and rat or pig model in vivo to evaluate urinary crystal adherence

  Kana Hayashi, Katsumi Shigemura, Hiroshi Tanimoto, Kazuo Kumagai, Ralph Rolly Gonzales, Young-Min Yang, Koki Maeda, Hideto Matsuyama, Masato Fujisawa

  Abstract The current study aimed to establish an experimental model in vitro and in vivo of urinary crystal deposition on the surface of ureteral stents, to evaluate the ability to prevent crystal adhesion. Non-treated ureteral stents were placed in artificial urine under various conditions in vitro. In vivo, ethylene glycol and hydroxyproline were administered orally to rats and pigs, and urinary crystals and urinary Ca were investigated by Inductively Coupled Plasma-Optical Emission Spectrometer. in vitro, during the 3- and 4-week immersion periods, more crystals adhered to the ureteral stent in artificial urine model 1 than the other artificial urine models (p < 0.01). Comparing the presence or absence of urea in the composition of the artificial urine, the artificial urine without urea showed less variability in pH change and more crystal adhesion (p < 0.05). Starting the experiment at pH 6.3 resulted in the highest amount of crystal adhesion to the ureteral stent (p < 0.05). In vivo, urinary crystals and urinary Ca increased in rat and pig experimental models. This experimental model in vitro and in vivo can be used to evaluate the ability to prevent crystal adhesion and deposition in the development of new ureteral stents to reduce ureteral stent-related side effects in patients.

  Springer Science and Business Media LLC, May 2024, Scientific Reports, 14(1) (1), 12001

  [Refereed]

  Scientific journal


• Isopropanol concentration by osmotically assisted reverse osmosis

  Mengyang Hu, Kazuo Kumagai, Ralph Rolly Gonzales, Yu-Hsuan Chiao, Kecheng Guan, Takahiro Kawakatsu, Hideto Matsuyama

  Elsevier BV, Mar. 2024, Journal of Membrane Science, 697, 122581 - 122581

  [Refereed]

  Scientific journal


• Hybrid osmotically assisted reverse osmosis and reverse osmosis (OARO-RO) process for minimal liquid discharge of high strength nitrogenous wastewater and enrichment of ammoniacal nitrogen

  Ralph Rolly Gonzales, Keizo Nakagawa, Kazuo Kumagai, Susumu Hasegawa, Atsushi Matsuoka, Zhan Li, Zhaohuan Mai, Tomohisa Yoshioka, Tomoyuki Hori, Hideto Matsuyama

  Elsevier BV, Nov. 2023, Water Research, 246, 120716 - 120716

  [Refereed]

  Scientific journal


• Simple bio-inspired coating of ureteral stent for protein and bacterial fouling and calcium encrustation control

  Ralph Rolly Gonzales, Kazuo Kumagai, Zhe Yang, Youngmin Yang, Katsumi Shigemura, Hideto Matsuyama

  Encrustation, caused by deposition of calcium and magnesium salts present in urine, is a common problem of indwelling urinary devices, such as ureteral stent. Encrustation was also found to be related to urinary tract infections; thus, it is necessary to prepare ureteral stents with antibacterial and antifouling surfaces to mitigate the occurrence of encrustation. In this study, commercial ureteral stent was coated with polydopamine (PDA), formed from self-polymerization of dopamine. The PDA coating was optimized in terms of dopamine concentration, pH, and coating time using response surface methodology. The chosen response parameters for optimization were calcium oxalate (CaC2 O4 ) encrustation and protein adsorption. Optimized PDA coating conditions were determined to be the following: pH 9.0, 2 mg/mL DA, and 3 days coating. The optimized PDA-coated ureteral stent exhibited outstanding resistance against CaC2 O4 encrustation, protein fouling, and bacterial adhesion due to its hydrophilic and functional coating layer. In comparison with the pristine ureteral stent, PDA coating was able to suppress approximately 97% and 87% of CaC2 O4 and protein adsorption, respectively. The PDA-coated ureteral stent was compared against those of commercially available ureteral stents and found to have superior encrustation and protein fouling mitigation performance. Finally, PDA coating was found to be highly stable for a storage period of 90 days, whether stored in wet or dry conditions.

  Aug. 2023, Journal of biomedical materials research. Part B, Applied biomaterials, 111(8) (8), 1511 - 1522, English, International magazine

  [Refereed]

  Scientific journal


• Simple and Economical Downstream Process Development for Edible Oil Production from Oleaginous Yeast Lipomyces starkeyi

  Hiroya Taki, Kentaro Mine, Shinji Matsuo, Kazuo Kumagai, Hideto Matsuyama

  The production of palm oil, which is used in various foods, is associated with environmental destruction and climate change risks; therefore, there is an urgent need for sustainable alternatives. “Yeast oil” produced by Lipomyces starkeyi, an oil-producing yeast, is expected to solve these problems because its fatty acid composition is similar to that of palm oil. To date, we have successfully developed yeast oil as an edible alternative to palm oil. However, conventional processes, including cell collection and lyophilization, are difficult to industrialize in terms of equipment and cost. Therefore, a method for extracting yeast oil from the emulsified liquid generated by crushing the culture was investigated. It is presumed that the emulsified state is stable owing to the components derived from yeast cells and metabolites; thus, solid–liquid filtration separation was attempted before extraction. The extraction recovery ratio of yeast oil was 98.2% when a hexane/ethanol mixture (3:1) was added to the residue after filtration. Furthermore, the energy consumption and processing cost of this new process were estimated to be 26% and 34%, respectively, of that of conventional methods, suggesting that the new process has potential for practical applications.

  MDPI AG, May 2023, Processes, 11(5) (5), 1458 - 1458

  [Refereed]

  Scientific journal


• Applicability and antibacterial activity of polycyclic aromatic compound derivatives used as photocatalysts for water oxidation

  Yuichi Ichihashi, Tomoya Sekiguchi, Koki Hiramatsu, Yuya Tokui, Kazuo Kumagai, Hideto Matsuyama, Keita Taniya, Satoru Nishiyama

  Elsevier BV, May 2023, Applied Catalysis B: Environmental, 325, 122326 - 122326

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Unveiling the impact of imidazole derivative with mechanistic insights into neutralize interfacial polymerized membranes for improved solute-solute selectivity

  Titik Istirokhatun, Yuqing Lin, Ken Kinooka, Qin Shen, Pengfei Zhang, Yuandong Jia, Atsushi Matsuoka, Kazuo Kumagai, Tomohisa Yoshioka, Hideto Matsuyama

  Elsevier BV, Feb. 2023, Water Research, 230, 119567 - 119567

  [Refereed]

  Scientific journal


• Ammoniacal nitrogen concentration by osmotically assisted reverse osmosis

  Ralph Rolly Gonzales, Keizo Nakagawa, Susumu Hasegawa, Atsushi Matsuoka, Kazuo Kumagai, Tomohisa Yoshioka, Hideto Matsuyama

  Elsevier BV, Jan. 2023, Journal of Membrane Science, 665, 121122 - 121122

  [Refereed]

  Scientific journal


• Simulation of Thermoresponsive Draw Solute-Driven Forward Osmosis for Enhanced Pure Water Production in Seawater Desalination

  Michimasa Kishimoto, Ralph Rolly Gonzales, Shohei Goda, Masahiro Yasukawa, Atsuo Kumano, Eiji Kamio, Kazuo Kumagai, Hideto Matsuyama

  Jul. 2021, Industrial & Engineering Chemistry Research, 60(26) (26), 9548 - 9559

  [Refereed]

  Scientific journal


• Effect of branch structure of thermoresponsive oligomers on draw solution performance in forward osmosis process

  Asuka Inada, Kenichiro Yumiya, Kazuo Kumagai, Hideto Matsuyama

  Elsevier BV, Jan. 2021, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 609, 125659 - 125659

  [Refereed]

  Scientific journal


• Effect of the molecular weights of thermoresponsive polyalkylene glycol draw solutes on forward osmosis performance

  Asuka Inada, Kazuo Kumagai, Hideto Matsuyama

  Elsevier BV, Dec. 2020, Separation and Purification Technology, 252, 117462 - 117462

  [Refereed]

  Scientific journal


• Morpholine derivatives as thermoresponsive draw solutes for forward osmosis desalination

  Asuka Inada, Tomoki Takahashi, Kazuo Kumagai, Hideto Matsuyama

  Jun. 2019, Industrial and Engineering Chemistry Research, 58(27) (27), 12253 - 12260, English

  [Refereed]

  Scientific journal


• Development of thermoresponsive star oligomers with a glycerol backbone as the draw solute in forward osmosis process

  Asuka Inada, Kenichiro Yumiya, Tomoki Takahashi, Kazuo Kumagai, Yoko Hashizume, Hideto Matsuyama

  Mar. 2019, Journal of Membrane Science, 574, 147 - 153, English

  [Refereed]

  Scientific journal


• Inexpensive High-Throughput Screening of Kinase Inhibitors Using One-Step Enzyme-Coupled Fluorescence Assay for ADP Detection

  Riyo Maruki Imamura, Kazuo Kumagai, Hirofumi Nakano, Takayoshi Okabe, Tetsuo Nagano, Hirotatsu Kojima

  Mar. 2019, SLAS DISCOVERY, 24(3) (3), 284 - 294, English

  [Refereed]

  Scientific journal


• Streptococcus属細菌のクオラムセンシング伝達経路を阻害する低分子化合物の探索

  石井 誠志, 福井 健二, 横島 聡, 熊谷 和夫, 紅山 容子, 兒玉 哲也, 福山 透, 岡部 隆義, 長野 哲雄, 小島 宏建, 矢野 貴人

  生命科学系学会合同年次大会運営事務局, Dec. 2017, 生命科学系学会合同年次大会, 2017年度, [4AT26 - 1420)], Japanese


• Identification of novel selective P2Y(6) receptor antagonists by high-throughput screening assay

  Masaaki Ito, Shin-ichiro Egashira, Kazuki Yoshida, Tomoko Mineno, Kazuo Kumagai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Michio Ui, Isao Matsuoka

  Jul. 2017, LIFE SCIENCES, 180, 137 - 142, English

  [Refereed]

  Scientific journal


• High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway

  Seiji Ishii, Kenji Fukui, Satoshi Yokoshima, Kazuo Kumagai, Youko Beniyama, Tetsuya Kodama, Tohru Fukuyama, Takayoshi Okabe, Tetsuo Nagano, Hirotatsu Kojima, Takato Yano

  Jun. 2017, SCIENTIFIC REPORTS, 7, 4029, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A novel diacylglycerol kinase alpha-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response

  Ke Liu, Naoko Kunii, Megumi Sakuma, Atsumi Yamaki, Satoru Mizuno, Mayu Sato, Hiromichi Sakai, Sayaka Kado, Kazuo Kumagai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Yasuhito Shirai, Fumio Sakane

  Mar. 2016, JOURNAL OF LIPID RESEARCH, 57(3) (3), 368 - 379, English

  [Refereed]

  Scientific journal


• 浸透圧差が駆動力、FO膜による発電システム－海水淡水化のエネルギーコスト削減に期待－

  松山 秀人, 高橋 智輝, 三好 太郎, 熊谷 和夫

  加工技術研究会, 2015, コンバーテック, 43(12) (12), 10 - 13, Japanese

  Scientific journal


• High-Throughput Screening System To Identify Small Molecules That Induce Internalization and Degradation of HER2

  Masayuki Isa, Daisuke Asanuma, Shigeyuki Namiki, Kazuo Kumagai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Kenzo Hirose

  Oct. 2014, ACS CHEMICAL BIOLOGY, 9(10) (10), 2237 - 2241, English

  [Refereed]

  Scientific journal


• Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2

  Megumi Tarui, Hideo Shindou, Kazuo Kumagai, Ryo Morimoto, Takeshi Harayama, Tomomi Hashidate, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Takahide Nagase, Takao Shimizu

  Jul. 2014, JOURNAL OF LIPID RESEARCH, 55(7) (7), 1386 - 1396, English

  [Refereed]

  Scientific journal


• The DEAH-Box RNA Helicase DHX15 Activates NF-kappa B and MAPK Signaling Downstream of MAVS During Antiviral Responses

  Kenta Mosallanejad, Yusuke Sekine, Seiko Ishikura-Kinoshita, Kazuo Kumagai, Tetsuo Nagano, Atsushi Matsuzawa, Kohsuke Takeda, Isao Naguro, Hidenori Ichijo

  Apr. 2014, SCIENCE SIGNALING, 7(323) (323), ra40, English

  [Refereed]

  Scientific journal


• Development of a highly sensitive, high-throughput assay for glycosyltransferases using enzyme-coupled fluorescence detection

  Kazuo Kumagai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano

  Feb. 2014, ANALYTICAL BIOCHEMISTRY, 447, 146 - 155, English

  [Refereed]

  Scientific journal


• SPF-5506-A(4), a new peptaibol inhibitor of amyloid beta-peptide formation produced by Trichoderma sp.

  Nobuo Hosotani, Kazuo Kumagai, Shigeyuki Honda, Akira Ito, Takuro Shimatani, Ikutaro Saji

  Mar. 2007, JOURNAL OF ANTIBIOTICS, 60(3) (3), 184 - 190, English

  [Refereed]

  Scientific journal


• SPF-32629 A and B, novel human chymase inhibitors produced by Penicillium sp. (Journal of Antibiotics (2006) 59, (29-34))

  Shimatani, T., Hosotani, N., Ohnishi, M., Kumagai, K., Saji, I.

  2007, Journal of Antibiotics, 60(11) (11)

  [Refereed]

  Scientific journal


• A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord

  Shinjiro Kaneko, Akio Iwanami, Masaya Nakamura, Akiyoshi Kishino, Kaoru Kikuchi, Shinsuke Shibata, Hirotaka J. Okano, Takeshi Ikegami, Ayako Moriya, Osamu Konishi, Chikao Nakayama, Kazuo Kumagai, Toru Kimura, Yasufumi Sato, Yoshio Goshima, Masahiko Taniguchi, Mamoru Ito, Zhigang He, Yoshiaki Toyama, Hideyuki Okano

  Dec. 2006, NATURE MEDICINE, 12(12) (12), 1380 - 1389, English

  [Refereed]

  Scientific journal


• SPF-32629 A and B, novel human chymase inhibitors produced by Penicillium sp.

  T Shimatani, N Hosotani, M Ohnishi, K Kurnagai, Saji, I

  Jan. 2006, JOURNAL OF ANTIBIOTICS, 59(1) (1), 29 - 34, English

  [Refereed]

  Scientific journal


• Antimycins A(10)similar to A(16), seven new antimycin antibiotics produced by Streptomyces spp. SPA-10191 and SPA-8893

  N Hosotani, K Kumagai, H Nakagawa, T Shimatani, Saji, I

  Jul. 2005, JOURNAL OF ANTIBIOTICS, 58(7) (7), 460 - 467, English

  [Refereed]

  Scientific journal


• New 24-membered macrolides SPA-6952A and B produced by Streptomyces sp.

  N Hosotani, K Kumagai, H Nakagawa, T Shimatani, Saji, I

  Jun. 2005, JOURNAL OF ANTIBIOTICS, 58(6) (6), 409 - 411, English

  [Refereed]

  Scientific journal


• In vitro and in vivo characterization of a novel semaphorin 3A inhibitor, SM-216289 or xanthofulvin

  K Kikuchi, A Kishino, O Konishi, K Kumagai, N Hosotani, Saji, I, C Nakayama, T Kimura

  Oct. 2003, JOURNAL OF BIOLOGICAL CHEMISTRY, 278(44) (44), 42985 - 42991, English

  [Refereed]

  Scientific journal


• Axonal regeneration after administration of semaphorin 3A inhibitor into the injured spinal cord

  S Kaneko, A Iwanami, M Nakamura, S Miyao, A Kishino, K Kikuchi, T Kimura, K Kumagai, Y Toyama, H Okano

  Oct. 2003, JOURNAL OF NEUROTRAUMA, 20(10) (10), 1133 - 1133, English

  [Refereed]


• Xanthofulvin, a novel semaphorin inhibitor produced by a strain of Penicillium

  K Kumagai, N Hosotani, K Kikuchi, T Kimura, Saji, I

  Jul. 2003, JOURNAL OF ANTIBIOTICS, 56(7) (7), 610 - 616, English

  [Refereed]

  Scientific journal


• Pharmacological profile of a new orally active growth hormone secretagogue, SM-130686

  J Nagamine, R Nagata, H Seki, N Nomura-Akimaru, Y Ueki, K Kumagai, M Taiji, H Noguchi

  Dec. 2001, JOURNAL OF ENDOCRINOLOGY, 171(3) (3), 481 - 489, English

  [Refereed]

  Scientific journal


• Oxindole derivatives as orally active potent growth hormone secretagogues

  T Tokunaga, WE Hume, T Umezome, K Okazaki, Y Ueki, K Kumagai, S Hourai, J Nagamine, H Seki, M Taiji, H Noguchi, R Nagata

  Dec. 2001, JOURNAL OF MEDICINAL CHEMISTRY, 44(26) (26), 4641 - 4649, English

  [Refereed]

  Scientific journal


• Synthesis and biological evaluation of oxindole derivatives as novel growth hormone secretagogues.

  R Nagata, T Tokunaga, WE Hume, T Umezome, K Okazaki, Y Ueki, K Kumagai, J Nagamine, H Seki, M Taiji, H Noguchi

  Aug. 2001, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 222, U670 - U670, English

  [Refereed]


• Oxindole derivatives as orally active potent growth hormone secretagogues.

  R Nagata, T Tokunaga, EW Hume, K Okazaki, Y Ueki, K Kumagai, J Nagamine, H Seki, M Taiji, H Noguchi

  Aug. 2000, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 220, U591 - U591, English

  [Refereed]


• (2R-trans)-2-butyl-5-heptylpyrrolidine as a potent sigma receptor ligand produced by Streptomyces longispororuber

  K Kumagai, K Shono, H Nakayama, Y Ohno, Saji, I

  May 2000, JOURNAL OF ANTIBIOTICS, 53(5) (5), 467 - 473, English

  [Refereed]

  Scientific journal


• ENANTIOSELECTIVE HYDROLYSIS OF (RS)-2-ISOPROPYL-4'-CHLOROPHENYLACETONITRILE BY PSEUDOMONAS SP B21C9

  S MASUTOMO, A INOUE, K KUMAGAI, R MURAI, S MITSUDA

  Apr. 1995, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 59(4) (4), 720 - 722, English

  [Refereed]


• INCREASED ANTI-HIV-1 ACTIVITY OF CD4 CDR3-RELATED SYNTHETIC PEPTIDES BY SCRAMBLING AND FURTHER STRUCTURAL MODIFICATIONS, INCLUDING D-ISOMERIZATION AND DIMERIZATION

  K KUMAGAI, K TOKUNAGA, M TSUTSUMI, K IKUTA

  Sep. 1993, FEBS LETTERS, 330(2) (2), 117 - 121, English

  [Refereed]

  Scientific journal


• PC-766B, A NEW MACROLIDE ANTIBIOTIC PRODUCED BY NOCARDIA-BRASILIENSIS .2. ISOLATION, PHYSICOCHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION

  K KUMAGAI, A FUKUI, S TANAKA, M IKEMOTO, K MORIGUCHI, S NABESHIMA

  Jul. 1993, JOURNAL OF ANTIBIOTICS, 46(7) (7), 1139 - 1144, English

  [Refereed]

  Scientific journal


• PC-766B, A NEW MACROLIDE ANTIBIOTIC PRODUCED BY NOCARDIA-BRASILIENSIS .1. TAXONOMY, FERMENTATION AND BIOLOGICAL-ACTIVITY

  K KUMAGAI, K TAYA, A FUKUI, M FUKASAWA, M FUKUI, S NABESHIMA

  Jun. 1993, JOURNAL OF ANTIBIOTICS, 46(6) (6), 972 - 978, English

  [Refereed]

  Scientific journal


• CHARACTERIZATION OF A UNIQUE SCRAMBLED PEPTIDE DERIVED FROM THE CD4 CDR3-RELATED REGION WHICH SHOWS SUBSTANTIAL ACTIVITY FOR BLOCKING HIV-1 INFECTION

  K OHKI, K KUMAGAI, S MITSUDA, T TAKANO, T KIMURA, K IKUTA

  Apr. 1993, VACCINE, 11(6) (6), 682 - 686, English

  [Refereed]

  Scientific journal


• T1801 A, B, C, AND D, NEW QUINONE AND HYDROQUINONE ANTIBIOTICS PRODUCED BY A STRAIN OF PSEUDOMONAS

  K KUMAGAI, M KATO, S NABESHIMA, S TSUYUMU

  Sep. 1992, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 56(9) (9), 1439 - 1442, English

  [Refereed]

  Scientific journal


• Selective killing of HIV-infected cells by liposomes composed of dimyristoylphosphatidylcholine/phosphatidylserine/cholesterol

  K. Kumagai, S. Nabeshima, S. Kato, M. Watanabe, K. Ikuta

  1991, Antiviral Chemistry and Chemotherapy, 2(3) (3), 143 - 148, English

  [Refereed]

  Scientific journal

• 浸透圧補助逆浸透法（Osmotically Assisted Reverse Osmosis）による有機溶剤水溶液の 高濃度膜濃縮

  熊谷和夫

  Jun. 2026, 分離技術, 56(3) (3), 166 - 170

  [Invited]


• メタン発酵にむけた正浸透膜法による都市下水の濃縮

  岡本泰直, 松岡淳, 松岡淳, GONZALES Ralph Rolly, 長谷川進, 吉田弦, 熊谷和夫, 神尾英治, 神尾英治, 北河享, 吉岡朋久, 中川敬三, 松山秀人, 松山秀人

  2024, 化学工学会年会研究発表講演要旨集(CD-ROM), 89th


• 神戸大学先端膜工学センターにおける産学連携の取り組み

  KUMAGAI KAZUO, 西原 圭志, MATSUYAMA HIDETO

  産学連携学会, Dec. 2015, 産学連携学, 12(1) (1), 3 - 9, Japanese

  [Refereed][Invited]

  Introduction scientific journal


• 創薬スクリーニングに有用な高感度かつ低コストの糖転移酵素およびキナーゼのアッセイ系の開発

  KUMAGAI KAZUO, KOJIMA HIROTATSU, OKABE TAKAYOSHI, NAGANO TETSUO

  和光純薬工業株式会社, Apr. 2015, 和光純薬時報, 83(2) (2), 14 - 17, Japanese

  [Invited]

  Introduction other


• High throughput screening system for development of anti-cancer drugs inducing HER2 internalization

  Masayuki Isa, Daisuke Asanuma, Shigeyuki Namiki, Kazuo Kumagai, Hirotatsu Kojima, Tajayoshi Okabe, Tetsuo Nagano, Kenzo Hirose

  2013, JOURNAL OF PHARMACOLOGICAL SCIENCES, 121, 232P - 232P, English

  Summary international conference

• The Role of Exosomes in Metabolic Syndrome and Cell Therapy, in Advances in Metabolic Syndrome and Hypoglycemia

  Naofumi Shiomi, Pengfei Zhang, Kazuo Kumagai, Hideto Matsuyama

  Joint work, Feb. 2026, ISBN: 9781836357094


• 生命科学から創薬へのイノベーション（第11章 低分子化合物スクリーニング技術開発─アカデミアでの大規模スクリーニングを可能にするアッセイシステムの開発─）

  KUMAGAI kazuo, NAGANO Tetsuo

  Joint work, 南山堂, Oct. 2014, Japanese

  Scholarly book


• 研究成果を薬につなげるアカデミア創薬の戦略と実例（第1章2. アカデミア創薬における化合物スクリーニングのポイント－偽陽性ヒットをいかに見極めるか）

  熊谷 和夫

  Joint work, 羊土社, Jan. 2014, Japanese

  Scholarly book

• 浸透圧補助逆浸透（OARO）法による有機溶剤水溶液濃縮における共存成分の影響

  熊谷和夫, 細川智子, 松山秀人

  日本膜学会第48年会, Jun. 2026


• 医薬品製造プロセスにおける濃縮・溶媒交換への膜分離技術の適用

  熊谷和夫, Ralph Rolly Gonzales, 黒田貴一, 森田悠司, 間中敦史, 村瀬辰史, 田中洋明, 田中雅巳, 勝川幹基, 松山秀人

  日本プロセス化学会2023ウィンターシンポジウム, Dec. 2023

  [Invited]

  Invited oral presentation


• 浸透圧補助逆浸透法（OARO）による高沸点有機溶媒水溶液の高度濃縮

  熊谷和夫, MengYang Hu, 川島敏行, 松山秀人

  日本膜学会「第45年会」・ 「膜シンポジウム2023」合同大会, Nov. 2023

  Oral presentation


• 医薬品製造プロセスにおける濃縮・溶媒交換への膜分離技術の適用

  熊谷和夫, Ralph Rolly Gonzales, 黒田貴一, 森田悠司, 間中敦史, 村瀬辰史, 田中洋明, 田中雅巳, 勝川幹基, 松山秀人

  日本プロセス化学会2023サマーシンポジウム, Aug. 2023

  Poster presentation


• 浸透圧補助逆浸透法（OARO）膜プロセスによるイソプロパノール水溶液の高度濃縮

  熊谷和夫, MengYang Hu, 川勝孝博, 松山秀人

  日本膜学会 膜シンポジウム2022, Nov. 2022

  Oral presentation


• Development of Steric Thermoresponsive Block-co-oligomers having Glycerol Substructure as Draw Solute for Forward Osmosis Process

  K. Kumagai, A. Inada, K. Yumiya, Y. Hashizume, H. Matsuyama

  The 12th Conference of the Aseanian Membrane Society (AMS 12), Jul. 2019, English, International conference

  Poster presentation


• 温度応答性モルフォリン誘導体の相分離性評価と正浸透法への応用

  INADA ASUKA, TAKAHASHI TOMOKI, KUMAGAI KAZUO, MATSUYAMA HIDETO

  化学工学会第84年会, Mar. 2019, Japanese, 化学工学会, 東京, Domestic conference

  Oral presentation


• 神戸大学先端膜工学センター／先端膜工学研究推進機構における産学官連携の取り組み

  NISHIHARA KEISHI, KUMAGAI KAZUO, SHINTANI TAKUJI, MATSUYAMA HIDETO

  産学連携学会第16回大会, Jun. 2018, Japanese, 山口, Domestic conference

  Oral presentation


• 脂質二分子膜のアルキル鎖長がAmphotericin Bの物質透過性に及ぼす影響

  SAEKI DAISUKE, 高井徹, KUMAGAI KAZUO, MATSUYAMA HIDETO

  日本膜学会第40年会, May 2018, Japanese, 東京, Domestic conference

  Oral presentation


• 鎖長の異なる脂質二分子膜におけるAmphotericin Bの水/イオン透過性評価

  高井 徹, SAEKI DAISUKE, KUMAGAI KAZUO, MATSUYAMA HIDETO

  化学工学会第83回年会, Mar. 2018, Japanese, 大阪, Domestic conference

  Poster presentation


• 研究設備共用化の取り組み

  KUMAGAI KAZUO

  地域イノベーション戦略支援プログラム活動報告会, Feb. 2018, Japanese, 神戸, Domestic conference

  Oral presentation


• Characterization of membrane performance of supported lipid bilayers incorporating amphotericin B as water channels

  Toru Takai, Daisuke Saeki, Kazuo Kumagai, Hideto Matsuyama

  2017 International Congress on Membranes and Membrane Processes (ICOM2017), Jul. 2017, English, USA(San Francisco), International conference

  Poster presentation


• 水処理膜を指向したAmphotericin Bのリン脂質二分子膜中での物質透過性評価

  高井 徹, SAEKI DAISUKE, KUMAGAI KAZUO, MATSUYAMA HIDETO

  日本膜学会第39年会, May 2017, Japanese, 東京, Domestic conference

  Poster presentation


• Characterization of Separation Function of Amphotericin B for Biomimetic Water Purification Membrane

  Toru Takai, Daisuke Saeki, Kazuo Kumagai, Hideto Matsuyama

  The 5th Asian Graduate Student Symposium on Membrane Engineering (AGSM5), Apr. 2017, English, JAPAN（KOBE), Domestic conference

  Oral presentation


• 酵素カップリング法を用いた糖転移酵素の高感度蛍光HTSアッセイ系の開発

  KUMAGAI KAZUO, 小島 宏建, 岡部 隆義, 長野 哲雄

  日本薬学会第135年会（神戸）, Mar. 2015, Japanese, 神戸（神戸学院大学・兵庫医療大学）, Domestic conference

  Poster presentation


• 酵素カップリング法によるキナーゼの新しい高感度蛍光HTSアッセイ系の開発

  成瀬 健, KUMAGAI KAZUO, 今村 理世, 小島 宏建, 岡部 隆義, 長野 哲雄, 定村 佳房

  日本薬学会第135年会（神戸）, Mar. 2015, Japanese, Domestic conference

  Poster presentation


• アカデミアで創薬スクリーニング研究を行う際の課題とそれを可能とする新規HTSアッセイ系の開発―キナーゼ及び糖転移酵素を創薬標的として―

  KUMAGAI KAZUO

  日本薬学会第135年会（神戸）, Mar. 2015, Japanese, 神戸（神戸学院大学・兵庫医療大学）, Domestic conference

  Public discourse


• サリチル酸配糖化酵素を用いた抵抗性誘導剤の標的ベース探索

  TANIGAWA Yurika, WATANABE Megumi, KUMAGAI Kazuo, KOUZAI Yusuke, YAMANAKA Yurie, KIMURA Mamiko, INAGAKI Yoshishige, YAMAMOTO Mikihiro, ICHINOSE Yuki, TOYODA Kazuhiro, NOUTOSHI Yoshiteru

  日本植物病理学会関西部会, Sep. 2014, Japanese, 日本植物病理学会関西部会, 富山大学, Domestic conference

  Poster presentation


• High-throughput screeningによるPAF生合成酵素（LPCAT2）阻害剤の同定

  TARUI Megumi, SHINDOU Hideo, MORIMOTO Ryo, HARAYAMA Takeshi, HASHIDATE Tomomi, KUMAGAI Kazuo, NAGANO Tetsuo, NAGASE Takahide, SHIMIZU Takao

  第56回日本脂質生化学会大会, Jun. 2014, Japanese, 日本脂質生化学会, 近畿大学, Domestic conference

  Oral presentation

• 有機溶剤超ろ過（OSRO）膜の創製に基づく革新分離プロセスの基盤的構築

  松山 秀人, 後藤 雅宏, 都留 稔了, 吉岡 朋久, 長澤 寛規, 中川 敬三, 松岡 淳, 熊谷 和夫

  日本学術振興会, 科学研究費助成事業, 基盤研究(A), 神戸大学, 01 Apr. 2025 - 31 Mar. 2029


• 革新省エネ分離技術による廃水からの希少資源循環

  根岸雄一, 松山秀人, 岡本泰直, 熊谷和夫, 川勝孝博, 北河享

  環境省, 環境研究総合推進費, 東北大学、神戸大学、栗田工業株式会社, Apr. 2025 - Mar. 2028


• 希薄有機溶媒水溶液の新たな膜ろ過分離による高度濃縮法の開発

  科研費 基盤研究（C）, Apr. 2023 - Mar. 2026


• 排ガス・廃水中希薄有害物質の無害化・利用技術開発

  国立研究開発法人新エネルギー・産業技術総合開発機構（NEDO）, エネルギー・環境新技術先導研究プログラム, May 2021 - Mar. 2023, Coinvestigator

• 正浸透膜モジュール発電システム

  岸本通雅, 熊谷和夫, 松山秀人

  特願2019-159194, 01 Sep. 2019, 国立大学法人神戸大学, 特開2021-037441, 11 Mar. 2021

  Patent right