Research activity information

• Laparoscopic Anterior-Approach Right Posterior Sectionectomy for Huge Hepatocellular Carcinoma: Technique and Short-Term Outcomes.

  Takeshi Urade, Masahiro Kido, Shohei Komatsu, Kenji Fukushima, Toshihiko Yoshida, Keisuke Arai, Kosuke Iguchi, Masayuki Akita, Takuya Mizumoto, Jun Ishida, Yoshihide Nanno, Hiroaki Yanagimoto, Takumi Fukumoto

  BACKGROUND: Laparoscopic liver resection is technically demanding for hepatocellular carcinoma (HCC) ≥10 cm in the right liver. In open liver resection, the anterior approach is established for large right-lobe tumors because it avoids parenchymal compression during mobilization.1, 2 However, its laparoscopic use remains limited,3 particularly in right posterior sectionectomy (RPS). This study describes the technique and perioperative outcomes of laparoscopic RPS using the anterior approach for huge HCCs. METHODS: Among 799 minimally invasive liver resections performed between 2011 and 2025, four men (median age 72.5 years, range 60-84) with huge tumors (median diameter 11.5 cm, range 10-12) underwent laparoscopic (extended) RPS with an anterior approach. As the tumor bulk caused firm adhesion to the diaphragm and retroperitoneum, the right lobe was left in situ. Parenchymal transection was initiated caudally and progressed cranially along the right inferior vena cava. The specimen was detached only after the transection. Patients were placed in the left hemilateral decubitus position with French lithotomy, and clamp-crushing was used for transection. RESULTS: Two standard and two extended RPSs were completed. The median operative time was 524 minutes (range 418-603), and blood loss was 80 mL (range 10-550); no transfusions were required. The median weight was 753.5 g (range 450-934). No Clavien-Dindo ≥IIIa complications occurred. The median postoperative stay was 11 days (range 9-16). All margins were negative. CONCLUSIONS: Laparoscopic anterior-approach RPS is feasible and safe for huge right posterior HCCs, enabling secure transection without mobilization and yielding favorable short-term outcomes.

  Aug. 2026, Annals of surgical oncology, 33(8) (8), 7061 - 7062, English, International magazine

  Scientific journal


• Clinical impact of indocyanine green fluorescence imaging on perioperative outcomes in laparoscopic anatomical liver segmentectomy.

  Motochika Hamanaka, Takeshi Urade, Shohei Komatsu, Kenji Fukushima, Shinichi So, Toshihiko Yoshida, Keisuke Arai, Kosuke Iguchi, Masayuki Akita, Takuya Mizumoto, Jun Ishida, Yoshihide Nanno, Sadaki Asari, Hiroaki Yanagimoto, Masahiro Kido, Takumi Fukumoto

  BACKGROUND: Laparoscopic anatomical segmentectomy is technically demanding due to the lack of visible surface landmarks identifying segmental borders. While indocyanine green (ICG) fluorescence imaging offers real-time navigation, its specific impact on anatomical orientation remains understudied. We evaluated the clinical impact of ICG fluorescence guidance on perioperative efficiency and outcomes in laparoscopic anatomical segmentectomy. METHODS: We analyzed 78 consecutive patients (2017-2025) undergoing laparoscopic anatomical segmentectomy, stratified into ICG-guided (n = 51, negative staining) and conventional (n = 27) groups. Endpoints included perioperative outcomes (operative time, complications, and hospital stay), anatomical precision (RMSE between simulated volume and specimen weight), and long-term prognosis (RFS/OS) in a hepatocellular carcinoma (HCC) subgroup operated before 2023. RESULTS: While the non-ICG group included a higher proportion of high-difficulty cases according to the IWATE criteria (85.2 vs. 58.8%; p = 0.022), the ICG group demonstrated a substantially shorter median operative time (369 vs. 478 min; p < 0.001). Notably, the ICG group achieved zero major morbidity (Clavien-Dindo ≥ IIIa), whereas the conventional group had a rate of 22.2% (p < 0.001). The ICG group also showed superior anatomical precision with a lower RMSE (46.97 vs. 59.36). Intraoperative blood loss and R0 resection rates were comparable. Subgroup analysis confirmed that the ICG group maintained superior efficiency even in the later study period. In the HCC subset, RFS and OS were comparable between the groups (p = 0.352 and p = 0.080, respectively), indicating the oncological safety of the ICG-guided approach. CONCLUSIONS: ICG fluorescence guidance with negative staining improves operative efficiency and safety in laparoscopic anatomical segmentectomy. By visualizing the otherwise invisible demarcation, this technique streamlines parenchymal transection and is associated with reduced major morbidity. While the baseline difficulty imbalance warrants cautious interpretation, our findings suggest that ICG navigation provides a feasible and promising approach for improving surgical precision and outcomes.

  Jul. 2026, Surgical endoscopy, 40(7) (7), 5751 - 5759, English, International magazine

  Scientific journal


• Postoperative liver function trajectories and risk factors after hepatectomy for hepatocellular carcinoma.

  Masaki Omori, Shohei Komatsu, Motochika Hamanaka, Masahiro Kido, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Toshihiko Yoshida, Keisuke Arai, Dongha Lee, Masayuki Akita, Takuya Mizumoto, Jun Ishida, Yoshihide Nanno, Hiroaki Yanagimoto, Takumi Fukumoto

  PURPOSE: Hepatectomy is a curative treatment for hepatocellular carcinoma (HCC) but deteriorating postoperative liver function can limit its benefits, especially for patients with borderline resectable (BR) HCC. We evaluated postoperative liver function trajectories and their impact on long-term survival. METHODS: The subjects of this retrospective analysis were 790 patients who underwent initial curative hepatectomy, stratified by resectability (R, BR1, BR2) and modified albumin-bilirubin (mALBI) grade. Liver function was assessed via ALBI scores pre- and postoperatively. Deterioration was defined as an ALBI score ratio < 0.9. RESULTS: Median overall survival (OS) differed significantly, being 109.9, 54.4, and 40.4 months for the R, BR1, and BR2 groups, respectively (p < 0.001). While functional status at POD 90 influenced recurrence-free survival, deterioration at POD 180 was identified as a robust independent predictor of OS (HR 1.53, p = 0.005). Notably, no single preoperative or perioperative factor was a significant predictor of this long-term functional decline at POD 180. Postoperative recovery was heterogeneous, with 47.5% of patients with mALBI grade 2a improving to grade 1 by POD 180. CONCLUSIONS: Post-hepatectomy liver function at POD 180 is a key determinant of long-term survival. As this late deterioration is difficult to predict perioperatively, continuous monitoring of hepatic reserve is essential to maintain eligibility for subsequent multidisciplinary therapies.

  Jun. 2026, Surgery today, English, Domestic magazine

  Scientific journal


• Prognostic impact of malnutrition based on the global leadership initiative on malnutrition criteria in older patients undergoing liver resection for hepatocellular carcinoma.

  Satoshi Omiya, Takeshi Urade, Shohei Komatsu, Kenji Fukushima, Shinichi So, Toshihiko Yoshida, Keisuke Arai, Masayuki Akita, Takuya Mizumoto, Jun Ishida, Yoshihide Nanno, Sadaki Asari, Hiroaki Yanagimoto, Masahiro Kido, Takumi Fukumoto

  PURPOSE: This study aimed to evaluate preoperative malnutrition using the Global Leadership Initiative on Malnutrition (GLIM) criteria and determine whether its prognostic impact after initial liver resection (LR) differs between older (≥70 years) and younger (<70 years) patients with hepatocellular carcinoma (HCC). METHODS: This retrospective analysis included 330 patients with HCC who underwent LR between January 2011 and December 2019 at our institution. Overall survival (OS), recurrence-free survival (RFS), postoperative recurrence patterns, and treatment strategies for recurrence were compared between the two groups. RESULTS: Among the 330 patients with HCC, 150 and 180 were classified into younger and older groups, respectively. Preoperative severe malnutrition was independently associated with OS (p=0.001) and RFS (p=0.044) in older patients and with RFS (p=0.039), but not OS, in younger patients. Moreover, in older patients, preoperative malnutrition was associated with a lower rate of aggressive treatments for intrahepatic recurrence (p=0.018) and a higher rate of extrahepatic recurrence (p=0.023) after LR, which was not observed in younger patients. CONCLUSIONS: Severe malnutrition, as per the GLIM criteria, is a significant independent predictor of OS and RFS in older patients with HCC who underwent LR. Preoperative malnutrition was associated with the treatment strategies for intrahepatic recurrence and the rate of extrahepatic recurrence in this population.

  Jun. 2026, Surgery today, English, Domestic magazine

  Scientific journal


• Intraoperative frozen section analysis of the portal or superior mesenteric vein transection margin in pancreatectomy with venous resection for pancreatic cancer.

  Jun Ishida, Hirochika Toyama, Yoshihide Nanno, Takuya Mizumoto, Dongha Lee, Masayuki Akita, Keisuke Arai, Toshihiko Yoshida, Shinichi So, Takeshi Urade, Kenji Fukushima, Shohei Komatsu, Sadaki Asari, Hiroaki Yanagimoto, Masahiro Kido, Takumi Fukumoto

  BACKGROUND: Portomesenteric vein (PMV) resection is performed for pancreatic ductal adenocarcinoma with venous invasion. However, positive transection margins may lead to local recurrence. This study aimed to evaluate whether routine intraoperative frozen section analysis (FSA) reduces positive PMV transection margins. METHODS: This retrospective study reviewed patients who underwent pancreatectomy with PMV resection at Kobe University Hospital from 2010 to 2020. Routine FSA of the PMV transection margin was introduced in 2017. Clinicopathological factors and the incidence of positive PMV transection margins were compared between patients who underwent FSA (PMV frozen [+]) and those who did not (PMV frozen [-]). Cox regression was used to assess the prognostic effect of margin status. RESULTS: A total of 115 patients were included (57 in the PMV frozen [+] group and 58 in the PMV frozen [-] group). The rate of positive PMV transection margins was significantly lower in the PMV frozen (+) group than in the PMV frozen (-) group (1.8% vs 17.2%, respectively; P =.003). Multivariate logistic regression analysis demonstrated that intraoperative FSA of the PMV transection margin was an independent factor associated with a reduced risk of positive PMV transection margins on final pathological diagnosis (odds ratio, 13.7 [95% CI, 1.61-116.7]; P =.017). However, the positive PMV transection margin was not associated with overall survival (hazard ratio, 0.96 [95% CI, 0.31-2.50; P =.937). CONCLUSION: Routine FSA of the PMV transection margin markedly reduces positive PMV transection margins after pancreatectomy. However, the prognostic effect of a positive PMV transection margin remains unclear. Larger prospective studies are needed to determine its prognostic relevance.

  Jun. 2026, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 30(6) (6), 102410 - 102410, English, International magazine

  Scientific journal


• The convenience of contrast-enhanced intraoperative ultrasonic cholangiography in liver resection: a study protocol for a randomized, prospective, off-label trial.

  Takeshi Urade, Kentaro Oji, Masahiro Kido, Shohei Komatsu, Hidetoshi Gon, Kenji Fukushima, Shinichi So, Toshihiko Yoshida, Keisuke Arai, Hayata Sano, Sae Murakami, Takumi Fukumoto

  BACKGROUND: Intraoperative cholangiography (IOC) is widely used to delineate biliary anatomy and confirm ductal integrity during liver resection. However, conventional radiographic IOC requires a C-arm set-up, may interrupt the operative workflow, and exposes patients and operating-room personnel to ionizing radiation. Contrast-enhanced intraoperative ultrasonic cholangiography (CE-IOUSC) combines intrabiliary injection of highly diluted perfluorobutane microbubbles (Sonazoid®) with contrast harmonic ultrasonography, enabling real-time visualization that can be repeated on demand without radiation. We hypothesize that CE-IOUSC provides superior procedural convenience while maintaining biliary visualization and safety. METHODS: This is a single-center, open-label, randomized, parallel-group, phase III comparative trial. Adults (≥ 20 years) scheduled for liver resection, including living donors, are eligible when cholecystectomy and transcystic catheterization via the cystic duct are feasible. After informed consent, participants are randomized 1:1 (stratified by liver condition: normal vs. impaired) to CE-IOUSC or conventional radiographic IOC using a computer-generated sequence. In both arms, cholangiography is performed twice-before and after bile duct division-with additional imaging permitted as clinically required. Conventional IOC uses diluted iothalamate contrast (Urografin®) under C-arm fluoroscopy. CE-IOUSC uses 1,000-fold diluted Sonazoid® administered through the cystic duct and evaluated using intraoperative ultrasonography in contrast mode. Cross-over "rescue" cholangiography with the alternative modality is allowed when the assigned method is unsuccessful or inadequate. The primary endpoint is the cumulative time required to complete intraoperative cholangiography, including any additional imaging and repeated attempts. Secondary endpoints include surgeon-rated usability (5-point Likert questionnaire completed by the primary operator immediately after surgery), detectability of biliary structures (segmental visualization rates assessed by predefined criteria), postoperative biliary complications (bile leak or stricture graded by Clavien-Dindo), cross-over rescue efficacy, and safety outcomes (procedure-related adverse events and perioperative laboratory changes). Outcomes will be analyzed primarily on an intention-to-treat basis. DISCUSSION: This trial will quantify whether CE-IOUSC improves the efficiency and usability of intraoperative biliary imaging without compromising visualization or patient safety. The results will inform evidence-based adoption of ultrasound-based cholangiography as a practical alternative to conventional radiographic IOC in liver resection. TRIAL REGISTRATION: Japan Registry of Clinical Trials (jRCT), jRCTs051230202.

  May 2026, BMC surgery, 26(1) (1), English, International magazine

  Scientific journal


• Preliminary clinical outcomes of shoelace repair with internal brace for ulnar collateral ligament injuries with chronic avulsion bone fragments in student baseball players.

  Yasuhiro Mitsui, Kazuto Higuchi, Koji Hara, Ryunosuke Abe, Syuichiro Sakai, Toshihiko Yoshida

  BACKGROUND: Ulnar collateral ligament (UCL) repair with internal brace augmentation has demonstrated promising results. Traditionally, chronic avulsion bone fragments (BFs) at the UCL attachment site have been considered as indications for reconstruction. We applied a shoelace repair technique combined with internal bracing in student baseball players with and without such BFs. We hypothesized that favorable clinical outcomes could be achieved regardless of the presence of BFs. This study aimed to evaluate the clinical outcomes of shoelace repair with internal brace technique. METHODS: Eighteen student baseball players who underwent shoelace repair with internal brace were included. Based on pre-operative radiographs and computed tomography scans, patients were classified into those with BFs (n = 8) and those without (n = 10). Post-operative outcomes were assessed and compared between the 2 groups using Japan Orthopedic Association sports score, disabilities of the arm, shoulder, and hand sports module, Kerlan-Jobe Orthopedic Clinic score, and time to return to play (RTP). RESULTS: All the patients returned to play. No significant differences were observed between the groups in sports scores (P = .73, P = .74, P = .93, respectively), time to RTP (P = .58), or Conway scale (P = .67). No complications were observed in either group. CONCLUSION: Shoelace repair with internal brace may be a viable surgical option for UCL injuries with chronic avulsion BFs in carefully selected young athletes with minimal ligament degeneration and good tissue quality, particularly when early RTP is prioritized.

  May 2026, JSES international, 10(3) (3), 101649 - 101649, English, International magazine

  Scientific journal


• Frey術後の腹腔内遺残膵石が腹腔内膿瘍を形成した1例

  山下 光, 南野 佳英, 浅利 貞毅, 石田 潤, 水本 拓也, 李 東河, 大川 太資, 中村 浩之, 秋田 真之, 荒井 啓輔, 田井 謙太郎, 吉田 俊彦, 浦出 剛史, 福島 健司, 小松 昇平, 柳本 泰明, 木戸 正浩, 福本 巧

  兵庫県外科医会, Mar. 2026, 兵庫県外科医会会誌, 60, 29 - 29, Japanese


• Utility of Oncological Resectability Criteria in Recurrent Hepatocellular Carcinoma After Hepatectomy.

  Nobuaki Ishihara, Shohei Komatsu, Toshifumi Tada, Takanori Matsuura, Eisuke Ueshima, Keitaro Sofue, Masaki Omori, Masahiro Kido, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Kentaro Tai, Toshihiko Yoshida, Keisuke Arai, Hiroaki Yanagimoto, Yuzo Kodama, Takamichi Murakami, Takumi Fukumoto

  INTRODUCTION: Recurrent hepatocellular carcinoma (HCC) after hepatectomy remains a major clinical challenge, necessitating effective prognostic stratification. The oncological resectability criteria recently proposed by the Japan Liver Cancer Association and the Japanese Society of Hepato-Biliary-Pancreatic Surgery have not yet been validated in recurrent settings. This study aimed to evaluate the prognostic utility of these criteria in patients with recurrent HCC after hepatectomy. METHODS: This retrospective study included 505 patients with recurrent HCC following initial hepatectomy. Patients were classified into three groups-resectable (R), borderline resectable 1 (BR1), and borderline resectable 2 (BR2)-based on the oncological resectability criteria. Post-recurrence survival was evaluated using the Kaplan-Meier method, and multivariate analysis was performed to identify clinical factors associated with post-recurrence survival. RESULTS: Among the 505 patients, 248 patients were classified as R, 80 as BR1, and 177 as BR2. The median post-recurrence survival was 73.4 months for the R group, 33.6 months for the BR1 group, and 12.4 months for the BR2 group (p < 0.001). Multivariate analysis identified BR1/BR2 classification (p < 0.001), modified albumin-bilirubin grade 2b or 3 (p < 0.001), and recurrence within 1 year (p = 0.004) as independent predictors of poor post-recurrence survival. CONCLUSIONS: The oncological resectability criteria effectively stratified post-recurrence survival in patients with recurrent HCC. These findings suggest that a multidisciplinary approach may benefit patients with BR1 or BR2 recurrence. Further studies are warranted to explore optimal treatment strategies for recurrent HCC.

  Mar. 2026, Hepatology research : the official journal of the Japan Society of Hepatology, 56(3) (3), 368 - 376, English, International magazine

  Scientific journal


• Delayed Initiation of S-1 Adjuvant Chemotherapy Impairs Survival in Patients With Curatively Resected Pancreatic Cancer.

  Dongha Lee, Hirochika Toyama, Yoshihide Nanno, Hiroyuki Nakamura, Taisuke Okawa, Takuya Mizumoto, Jun Ishida, Masayuki Akita, Keisuke Arai, Toshihiko Yoshida, Shinichi So, Tsuyoshi Urade, Kenji Fukushima, Shohei Komatsu, Sadaki Asari, Hiroaki Yanagimoto, Masahiro Kido, Takumi Fukumoto

  BACKGROUND/AIM: The prognostic impact of the timing of adjuvant chemotherapy initiation in patients with resected pancreatic cancer is unclear. Therefore, this study aimed to investigate whether delayed initiation of S-1 adjuvant chemotherapy affects the survival of patients with resectable pancreatic cancer. PATIENTS AND METHODS: Patients who received S-1 adjuvant chemotherapy after undergoing R0/R1 resection were grouped according to whether adjuvant chemotherapy was initiated <60 (n=36) or ≥60 days (n=27) after surgery. Correlations between the time to chemotherapy initiation, clinicopathological factors, and survival were analyzed. RESULTS: The median and mean times to chemotherapy initiation were 58 and 61 days, respectively. The delayed group had worse 2-year overall (57% vs. 80%, p=0.032) and recurrence-free survival (35% vs. 54%, p=0.044) rates than the early group. These results were similar in patients who completed S-1 adjuvant chemotherapy. In multivariate analysis, delayed initiation of chemotherapy, R1 resection, and tumor size (≥40 mm) were independent prognostic factors for poor overall survival. The delayed group had more patients with severe postoperative complications (Clavien-Dindo grade ≥III) (30% vs. 8%, p=0.028) and delayed recovery of serum albumin levels (postoperative days 7, 14, and 30: p=0.040, 0.004, and 0.003, respectively) than the early group. CONCLUSION: Delayed initiation of S-1 adjuvant chemotherapy had an adverse impact on survival and was correlated with severe postoperative complications and delayed recovery of postoperative nutritional status.

  Feb. 2026, Anticancer research, 46(2) (2), 987 - 999, English, International magazine

  Scientific journal


• 肝細胞癌腫瘍学的切除可能性分類に基づいた肝切除および薬物療法治療成績の検証

  小松 昇平, 多田 俊史, 上嶋 英介, 松浦 敬憲, 祖父江 慶太郎, 木戸 正浩, 福島 健司, 浦出 剛史, 吉田 俊彦, 荒井 啓輔, 南野 佳英, 柳本 泰明, 児玉 裕三, 村上 卓道, 福本 巧

  (株)アークメディア, Jan. 2026, 肝胆膵, 92(1) (1), 112 - 114, Japanese


• Assessment of surgical difficulty in multiple laparoscopic liver resection using the aggregate value of scores based on the IWATE criteria.

  Daisuke Takimoto, Hidetoshi Gon, Shohei Komatsu, Kenji Fukushima, Takeshi Urade, Toshihiko Yoshida, Kentaro Tai, Keisuke Arai, Hiroaki Yanagimoto, Masahiro Kido, Takumi Fukumoto

  BACKGROUND: No studies exist regarding the methods for evaluating the surgical difficulty of multiple laparoscopic liver resection (MLLR). Hence, this study aimed to evaluate the usefulness of total scores calculated using the IWATE criteria for each resection site to assess the surgical difficulty of MLLR. METHODS: Medical records of patients who underwent MLLR at Kobe University Hospital between 2010 and 2023 were retrospectively reviewed. First, the total difficulty score was calculated for each patient by summing the IWATE criteria scores for all resection sites. Subsequently, we analyzed the correlation between this total difficulty score and surgical outcomes of MLLR. Finally, receiver operating characteristic analysis was employed to determine the optimal cutoff value of the total difficulty score. This cutoff value was used to categorize patients into the high- and low-total difficulty score groups, allowing for a comparison of their surgical outcomes. RESULTS: This study included 63 patients. The total difficulty score correlated with operation time [r = 0.54, 95% confidential interval (CI): 0.34-0.70, P < 0.001] and blood loss (r = 0.27, 95% CI: 0.03-0.90, P = 0.029), and was associated with postoperative complications (odds ratio: 1.33, 95% CI: 1.14-1.60, P < 0.001). Patients with total difficulty scores ≤ 11 and ≥ 12 were included in the low- and high-score groups, respectively. The high-score group exhibited longer operation times (481 min vs. 372 min, P = 0.001), greater blood loss (110 ml vs. 50 ml, P = 0.005), and higher overall complication rates (71% vs. 29%, P = 0.001) than the low-score group. CONCLUSIONS: The total difficulty score based on the IWATE criteria may be a useful tool for assessing surgical difficulty in MLLR.

  Jan. 2026, Surgical endoscopy, 40(1) (1), 182 - 191, English, International magazine

  Scientific journal


• Exploring the potential utility of modified difficulty scores based on the IWATE criteria for assessing the surgical difficulty of laparoscopic repeat liver resection.

  Hidetoshi Gon, Shohei Komatsu, Tatsuki Kusuhara, Daisuke Takimoto, Kenji Fukushima, Takeshi Urade, Toshihiko Yoshida, Kentaro Tai, Keisuke Arai, Hiroaki Yanagimoto, Masahiro Kido, Takumi Fukumoto

  BACKGROUND: Laparoscopic repeat liver resection (LRLR) is more challenging than initial laparoscopic liver resection in some cases because of intra-abdominal adhesions and liver deformation caused by previous operations. However, there are insufficient reports on difficulty scoring systems for LRLR. In this study, we aimed to explore whether the IWATE criteria and its modified scoring system could effectively predict surgical outcomes in patients undergoing LRLR. METHODS: Patients who underwent LRLR at the Kobe University Hospital between 2014 and 2024 were enrolled. We assessed the correlation between difficulty scores based on the IWATE criteria and LRLR surgical outcomes. The correlation between the modified difficulty scores and LRLR surgical outcomes were also evaluated. The modified difficulty scores were calculated by adding 2 points for ipsilateral recurrence and 1 point for a previous history of open liver resection to the original difficulty scores of the IWATE criteria. RESULTS: Eighty-four patients who underwent LRLR were enrolled. The median value of the IWATE criteria and modified difficulty score was 4 and 6, respectively. The median operation time and blood loss were 287 min and 10 mL, respectively. Nineteen (23%) patients experienced postoperative complications, wherein four (5%) had Clavien-Dindo grade ≥ IIIa complications. The IWATE criteria difficulty score correlated with operation time (r = 0.52, 95% confidential interval CI 0.35-0.66, P < 0.001) and blood loss (r = 0.26, 95% CI 0.05-0.45, P = 0.018), while the modified difficulty score correlated with operation time (r = 0.53, 95% CI 0.36-0.67, P < 0.001), blood loss (r = 0.31, 95% CI 0.11-0.49, P = 0.004), and overall postoperative complications (odds ratio 1.34 [interquartile range 1.23, 1.47], P = 0.019). CONCLUSIONS: The IWATE criteria and modified difficulty score may be useful for assessing LRLR surgical difficulty. Additionally, the modified difficulty score may more precisely predict the risk of postoperative complications.

  Dec. 2025, Surgical endoscopy, 39(12) (12), 8228 - 8236, English, International magazine

  Scientific journal


• Using the comprehensive complication index to assess the impact of Global Leadership Initiative on Malnutrition (GLIM)-defined malnutrition on postoperative complications after resection for biliary tract cancer.

  Yuki Okazoe, Hiroaki Yanagimoto, Daisuke Tsugawa, Masayuki Akita, Takuya Mizumoto, Toshihiko Yoshida, Shinichi So, Jun Ishida, Takeshi Urade, Yoshihide Nanno, Kenji Fukushima, Hidetoshi Gon, Shohei Komatsu, Sadaki Asari, Hirochika Toyama, Masahiro Kido, Takumi Fukumoto

  PURPOSE: The Global Leadership Initiative on Malnutrition (GLIM) criteria, proposed in 2018, provide universal diagnostic standards for malnutrition, a known risk factor for postoperative complications in patients with various cancers. However, its impact on surgery for biliary tract cancer (BTC) remains unclear. This study evaluates the relationship between GLIM-defined malnutrition and postoperative complications after resection for BTC. METHODS: The subjects of this retrospective study were patients who underwent pancreaticoduodenectomy or major hepatectomy with extrahepatic bile duct resection for BTC between January, 2013 and December, 2021. The comprehensive complication index (CCI), an indicator of postoperative complications, was calculated based on the total number and severity of postoperative complications. RESULTS: GLIM-defined malnutrition was diagnosed in143 (71.1%) of the total 201 patients. The median CCI was significantly higher in the GLIM-defined malnutrition group than in the non-malnutrition group (37.2 vs. 28.3; P < 0.001). Multivariate logistic regression analysis revealed that GLIM-defined malnutrition (odds ratio 2.87 [95% confidence interval 1.38-5.96], P = 0.005) and intraoperative blood loss > 1,000 mL (odds ratio 3.77 [95% confidence interval 1.06-13.47], P = 0.041) were independent predictors of high morbidity (CCI ≥ 37.1). CONCLUSION: Preoperative GLIM-defined malnutrition was closely associated with increased postoperative complications in patients who underwent resection for BTC.

  May 2025, Surgery today, 55(11) (11), 1598 - 1608, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Factors associated with resorption of calcific deposits in the shoulder with extracorporeal shock wave therapy.

  Shuichiro Sakai, Yasuhiro Mitsui, Azusa Miyamoto, Kazuto Higuchi, Toshihiko Yoshida, Koji Hara, Masafumi Gotoh

  BACKGROUND: Focused extracorporeal shock wave therapy (FSWT) is effective for treating calcific tendinitis of the shoulder. However, only a few reports exist on the factors related to calcium resorption after FSWT. Thus, this study aimed to investigate the factors associated with calcium resorption. METHODS: In 117 shoulders with chronic calcific rotator cuff tendinitis, FSWT was administered 9 times once every 2 weeks (a total of 16 weeks). After 9 sessions of FSWT, the shoulders were radiographed and categorized into complete resorption (CR) and incomplete resorption (ICR) groups. Evaluated parameters included age; duration of disease; Gärtner classification; size of calcium deposits; presence of blood flow around calcium deposits using the Doppler function of the ultrasound imaging system; Japanese Orthopaedic Association score; University of California at Los Angeles (UCLA) score; Disability of the Arm, Shoulder, and Hand score; and tenderness. RESULTS: The CR group included 93 shoulders (79.4%) and the ICR group included 24 shoulders (20.6%). In the two-arm comparison, CR showed significantly longer disease duration (P = .012) and high tenderness (P = .0013). Blood flow around calcium deposits was observed in 79.5% of shoulders in the CR group (P < .0001) and 29.1% in the ICR group. Type 1 Gärtner classification (P = .0009) was observed in 28 shoulders (30.1%) in the CR group and 17 shoulders (70.8%) in the ICR group. The 2 groups had no significant differences in age, size of calcium deposits, Japanese Orthopaedic Association score, or University of California at Los Angeles score. Multiple logistic regression analysis was performed using the following items that showed significant differences: absence of blood flow (odds ratio [OR], 8.51, 95% confidence interval [CI]: 2.24-22.8), Gärtner classification (OR, 5.60, 95%CI: 1.73-13.3), and duration of disease (OR, 1.06, 95%CI: 0.97-1.26). Longer disease duration, Gärtner type 1, and absence of blood flow around calcium deposits resulted in difficulty in calcium resorption. CONCLUSION: Patients with Gärtner type 1 with prolonged disease duration and absence of blood flow around calcium deposits may have difficulty in achieving complete resorption.

  May 2025, Journal of shoulder and elbow surgery, 34(5) (5), 1208 - 1215, English, International magazine

  Scientific journal


• Biomarker-guided strategy for Denver peritoneovenous shunts in refractory ascites: a retrospective single-center study.

  Yuhi Shimura, Shohei Komatsu, Yoshimasa Hashimoto, Miho Nishio, Yu Hashimoto, Michihiko Yoshida, Toshihiko Yoshida, Kenji Fukushima, Itsuo Fujita, Takumi Fukumoto

  PURPOSE: This study aimed to evaluate the utility of peritoneovenous shunt (PVS) placement for refractory ascites (RA) based on preoperative biomarkers. METHODS: This retrospective cohort study included patients with malignant and cirrhotic RA undergoing PVS placement treated at Sumoto Itsuki Hospital between January 2001 and March 2024. The efficacy of PVSs was defined according to the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE). The usefulness of the prognostic nutritional index, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and C-reactive protein-to-albumin ratio as prognostic indicators for the efficiency of PVS was evaluated. RESULTS: In total, 149 consecutive patients (malignant RA, n = 100; cirrhotic RA, n = 49) were included in this study. PVS placement satisfied the efficacy criteria for ascites in 102 (68%) patients in the entire cohort. The estimated glomerular filtration rate (eGFR) ≤ 30 mL/min/1.73 m2 was an independent predictor for the inefficacy of PVSs (odds ratio: 2.82, 95% CI: 1.04-7.73, P = 0.042). Based on receiver operating characteristic curve and multivariate analysis of the entire cohort, NLR ≥ 5.8 was an independent risk factor for death within 1 week after PVS placement (odds ratio: 18.2, 95% CI: 2.07-29.7, P = 0.016). CONCLUSION: PVS placement for RA may be a treatment option when preoperative eGFR is > 30 mL/min/1.73 m2 and NLR is < 5.8.

  Apr. 2025, Langenbeck's archives of surgery, 410(1) (1), 140 - 140, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Comparison of the surgical difficulty between segment 7 and 8 partial liver resection untilizing the laparoscopic and open approaches.

  Hidetoshi Gon, Akihiro Fujisawa, Shohei Komatsu, Motofumi Tanaka, Kenji Fukushima, Takeshi Urade, Toshihiko Yoshida, Keisuke Arai, Jun Ishida, Yoshihide Nanno, Daisuke Tsugawa, Hiroaki Yanagimoto, Hirochika Toyama, Masahiro Kido, Takumi Fukumoto

  PURPOSE: We aimed to investigate the differences in surgical difficulty between laparoscopic partial liver resections of segments 7 and 8. METHODS: We analyzed 173 patients who underwent partial liver resections of segments 7 or 8 between 2010 and 2022 at two institutions. We investigated differences in the surgical outcomes of each procedure using propensity score matching. We compared these outcomes with those of open partial liver resections for segments 7 and 8 to determine whether the differences were unique to the laparoscopic approach. RESULTS: Thirty and 54 patients underwent laparoscopic partial liver resections of segments 7 and 8. In the matched cohort (22 in each group), the operation time was significantly longer (377 vs. 278 min, P = 0.020) and the proportion of postoperative complications significantly higher in segment 7 (27% vs. 0%, P = 0.008). Forty-one and 48 patients underwent open partial liver resections of segments 7 and 8, respectively. There were no significant differences in the surgical outcomes between the segments in the matched cohort (20 in each group). CONCLUSIONS: Laparoscopic partial liver resections of segment 7 may be more challenging than that of segment 8. This difference in difficulty was not observed in open partial liver resections.

  Apr. 2025, Surgery today, 55(10) (10), 1383 - 1392, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Impact of depth of body cavity at the upper-right portion of the abdomen on open and laparoscopic liver resection of segment 7.

  Hidetoshi Gon, Shohei Komatsu, Hirotoshi Soyama, Motofumi Tanaka, Masahiro Kido, Kenji Fukushima, Takeshi Urade, Shinichi So, Toshihiko Yoshida, Keisuke Arai, Daisuke Tsugawa, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto

  PURPOSE: The impact of body-cavity depth on open (OLR) and laparoscopic liver resection (LLR) of segment 7 remains unclear. Therefore, we investigated the influence of body-cavity depth at the upper-right portion of the abdomen on LLR and OLR of segment 7. METHODS: In total, 101 patients who underwent segment-7 liver resection over 2010-2023 were included. Body-cavity depth was measured from the abdominal-wall surface to the deepest site on the right side of the liver. Patients were categorized into shallow (< 18.4 cm) and deep (≥ 18.4 cm) populations based on median body-cavity depth. We compared surgical outcomes between OLR and LLR in shallow and deep populations after propensity-score adjustments. RESULTS: In OLR and LLR groups, 27 and 22 patients in the shallow population, respectively, and 26 and 26 patients were included in the deep population, respectively, were included. The OLR group in the deep population had significantly greater blood loss than the corresponding LLR group (difference: 144 mL, 95% confidence interval (CI): [50, 238], P = 0.004). Other surgical outcomes, including operative time, were similar between groups. In the shallow population, the OLR group had significantly shorter operative time (difference: - 54 mL, 95% CI: [-101, - 6], P = 0.028) and similar blood loss than the LLR group. CONCLUSIONS: For segment-7 liver resection, LLR is likely favorable for patients with a deep body cavity, with similar operative time and lower blood loss compared to OLR. Body-cavity depth could be a useful indicator for determining the suitable surgical approach for segment-7 liver resection.

  Jan. 2025, Langenbeck's archives of surgery, 410(1) (1), 37 - 37, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• GLIM Criteria as Prognostic Factor in Patients Undergoing Adjuvant S-1 Chemotherapy for Biliary Tract Cancer.

  Ryunosuke Konaka, Hiroaki Yanagimoto, Daisuke Tsugawa, Masayuki Akita, Takuya Mizumoto, Toshihiko Yoshida, Shinichi Sou, Jun Ishida, Yoshihide Nanno, Takeshi Urade, Kenji Fukushima, Hidetoshi Gon, Shohei Komatsu, Sadaki Asari, Masahiro Kido, Hirochika Toyama, Takumi Fukumoto

  BACKGROUND/AIM: Biliary tract cancers (BTCs) have poor prognoses, with limited curative options beyond surgical resection. Adjuvant S-1 chemotherapy has shown survival benefits in Japanese patients undergoing resection for BTC. However, prognostic factors influencing survival in these patients remain uncertain. In this study, we aimed to investigate the efficacy of preoperative nutritional status using the Global Leadership Initiative on Malnutrition (GLIM) criteria as a prognostic factor in patients receiving adjuvant S-1 chemotherapy for BTC. PATIENTS AND METHODS: In this retrospective study, excluding intrahepatic cholangiocarcinoma, we evaluated 58 patients who underwent curative surgery for BTC at Kobe University from 2013 to 2022, followed by adjuvant S-1 chemotherapy. Nutritional status was classified by GLIM criteria into normal/moderate and severe malnutrition groups. Overall (OS) and recurrence-free (RFS) survival were analyzed using Kaplan-Meier and Cox proportional hazards models. RESULTS: Of the 58 patients, 3.4% had no malnutrition, 72.5% had moderate malnutrition, and 24.1% had severe malnutrition. Patients with severe malnutrition had significantly worse 5-year OS (24.7% vs. 52.5%, p=0.0014) and RFS (34.3% vs. 52.0%, p=0.0066). Severe malnutrition was an independent prognostic factor for poorer OS (hazard ratio=3.40, 95% confidence interval=1.46-7.94; p=0.0047) and RFS (hazard ratio=2.48, 95% confidence interval=1.07-5.76; p=0.035). No significant difference in S-1 completion rates was observed. CONCLUSION: Severe malnutrition, as defined by GLIM criteria, is a poor prognostic factor in patients with BTCs undergoing adjuvant S-1 chemotherapy.

  2025, Cancer diagnosis & prognosis, 5(5) (5), 557 - 565, English, International magazine

  Scientific journal


• Treatment Outcomes of Tyrosine Kinase Inhibitors and Durvalumab Plus Tremelimumab After Atezolizumab Plus Bevacizumab for Hepatocellular Carcinoma.

  Nobuaki Ishihara, Shohei Komatsu, Yoshihiko Yano, Yoshimi Fujishima, Jun Ishida, Masahiro Kido, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Toshihiko Yoshida, Kentaro Tai, Keisuke Arai, Hiroaki Yanagimoto, Hirochika Toyama, Takanori Matsuura, Toshifumi Tada, Yuzo Kodama, Takumi Fukumoto

  BACKGROUND/AIM: Atezolizumab plus bevacizumab (AteBev) is widely used as a first-line treatment for advanced hepatocellular carcinoma (HCC). However, evidence regarding the optimal drug sequence following AteBev treatment is limited. This study aimed to compare the treatment outcomes between tyrosine kinase inhibitors (TKIs) and durvalumab plus tremelimumab (DurTre) following AteBev treatment. PATIENTS AND METHODS: Overall, 134 consecutive patients who received AteBev for advanced HCC were enrolled in this study. Treatment outcomes were retrospectively compared between TKIs (AteBev→TKI group) and DurTre (AteBev→DurTre group). RESULTS: The AteBev→TKI and Ate→DurTre groups included 46 and 7 patients, respectively. The AteBev→TKI group had significantly longer median progression-free survival after second-line treatment (3.6 vs. 0.94 months, p<0.001). The disease control rate was significantly higher in the AteBev→TKI group (p=0.020). The serum alpha-fetoprotein levels significantly decreased at one month in the AteBev→TKI group (0.909 vs. 1.435, p=0.035), whereas the albumin-bilirubin score significantly decreased at one month in the AteBev→TKI group (0.875 vs. 0.952, p=0.017). Each group reported no new unmanageable adverse events. CONCLUSION: TKIs may be a more optimal drug sequence than DurTre after AteBev treatment from an oncological perspective. TKIs following AteBev treatment require careful monitoring for deteriorating liver function.

  Jan. 2025, Anticancer research, 45(1) (1), 251 - 260, English, International magazine

  Scientific journal


• Laparoscopic Liver Resection for Hepatocellular Adenomas in Pediatric Glycogen Storage Disease Type Ia: A Case With Consideration for Future Transplantation.

  Kentaro Oji, Takeshi Urade, Ryosuke Bo, Masahiro Kido, Shohei Komatsu, Hidetoshi Gon, Kenji Fukushima, Shinichi So, Toshihiko Yoshida, Kentaro Tai, Keisuke Arai, Takumi Fukumoto

  A 13-year-old girl presented with enlarging hepatocellular adenomas and a history of glycogen storage disease type Ia. Her liver function was well controlled by nutritional therapy. The options of resection and transplantation were considered, and the patient was successfully treated with laparoscopic liver resection. However, pathology revealed fatty liver, indicating that subsequent surgical treatment may be necessary. Herein, we report the patient's clinical progress, including the strategy for determining the surgical approach. In cases where the patient is a low priority for transplantation, laparoscopic liver resection is an important therapeutic choice, even though regrowth of residual lesions has been reported.

  2025, Asian journal of endoscopic surgery, 18(1) (1), e70090, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Usefulness of A Portal Vein Stent for Sinistral Portal Hypertension: A Case Report.

  Daisuke Takimoto, Jun Ishida, Hirochika Toyama, Yoshihide Nanno, Takuya Mizumoto, Toshihiko Yoshida, Takeshi Urade, Kenji Fukushima, Hidetoshi Gon, Daisuke Tsugawa, Shohei Komatsu, Hiroaki Yanagimoto, Masahiro Kido, Takumi Fukumoto

  INTRODUCTION: Portal vein (PV) and splenic vein (SV) stenosis are known complications of pancreatoduodenectomy (PD) and often lead to portal hypertension. PV stenosis extending to the SV confluence can result in sinistral portal hypertension (SPH), characterized by gastrointestinal varices and splenomegaly in the presence of normal liver function. There is no standardized treatment strategy for SPH following PD. CASE PRESENTATION: A 42-year-old female underwent robot-assisted PD for a pancreatic neuroendocrine tumor without immediate PV complications. Postoperatively, the patient experienced fluid retention; however, this did not pose a problem, and no therapeutic intervention was necessary. Two months later, imaging revealed PV stenosis and SV obstruction. Eleven months after surgery, the patient presented with melena, and imaging confirmed the presence of gastroesophageal varices with severe PV stenosis and complete SV obstruction. Endoscopic variceal ligation was performed, and the hemodynamic status of the portal system was assessed using computed tomography during arterial portography (CTAP). CTAP showed communication between the superior mesenteric vein and the SV via the middle colic vein. Therefore, we decided to perform PV stenting. The stent was successfully placed, resulting in a significant improvement in the esophageal varices. The patient was discharged on postoperative day 4, receiving anticoagulant therapy, with no further complications. CONCLUSIONS: This case demonstrates the efficacy of PV stenting after careful hemodynamic assessment in a patient who developed SPH due to PV stenosis and SV obstruction following PD.

  2025, Surgical case reports, 11(1) (1), English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 【肝癌診療2024】肝細胞癌集学的治療の進歩

  小松 昇平, 木戸 正浩, 権 英寿, 福島 健司, 浦出 剛史, 宗 慎一, 吉田 俊彦, 田井 謙太郎, 荒井 啓輔, 柳本 泰明, 外山 博近, 福本 巧

  (株)へるす出版, Sep. 2024, 消化器外科, 47(9) (9), 1059 - 1070, Japanese


• Comparison of laparoscopic liver resection for the ventral versus the dorsal areas of segment 8.

  Kentaro Oji, Takeshi Urade, Masahiro Kido, Shohei Komatsu, Hidetoshi Gon, Nobuaki Yamasaki, Kenji Fukushima, Shinichi So, Toshihiko Yoshida, Keisuke Arai, Masayuki Akita, Jun Ishida, Yoshihide Nanno, Daisuke Tsugawa, Sadaki Asari, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto

  PURPOSE: The technical difficulties of laparoscopic liver resection (LLR) are greatly associated with the location of liver tumors. Since segment 8 (S8) contains a wide area, the difficulty of LLR for S8 tumors may vary depending on the location within the segment, such as the ventral (S8v) and dorsal (S8d) area, but the difference is unclear. METHODS: We retrospectively investigated 30 patients who underwent primary laparoscopic partial liver resection for liver tumors in S8 at Kobe University Hospital between January 2018 and June 2023. RESULTS: Thirteen and 17 patients underwent LLR for S8v and S8d, respectively. The operation time was significantly longer (S8v 203[135-259] vs. S8d 261[186-415] min, P = 0.002) and the amount of blood loss was significantly higher (10[10-150] vs. 10[10-200] mL, P = 0.034) in the S8d group than in the S8v group. No significant differences were observed in postoperative complications or postoperative length of hospital stay. Additionally, intraoperative findings revealed that the rate at which the case performed partial liver mobilization in the S8d group was higher (2[15.4%] vs. 8[47.1%], P = 0.060) and the median parenchymal transection time of the S8d group was longer (102[27-148] vs. 129[37-175] min, P = 0.097) than those in the S8v group, but there were no significant differences. CONCLUSION: The safety of LLR for the S8d was comparable to that of LLR for S8v, although LLR for S8d resulted in longer operative time and more blood loss. THE TRIAL REGISTRATION NUMBER: B230165 (approved at December 26, 2023).

  Aug. 2024, Langenbeck's archives of surgery, 409(1) (1), 243 - 243, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Impact of bile leak on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection.

  Hidetoshi Gon, Shohei Komatsu, Hirotoshi Soyama, Motofumi Tanaka, Kenji Fukushima, Takeshi Urade, Shinichi So, Toshihiko Yoshida, Keisuke Arai, Jun Ishida, Yoshihide Nanno, Daisuke Tsugawa, Hiroaki Yanagimoto, Hirochika Toyama, Masahiro Kido, Takumi Fukumoto

  PURPOSE: The impact of postoperative bile leak on the prognosis of patients with hepatocellular carcinoma who underwent liver resection is controversial. This study aimed to investigate the prognostic impact of bile leak for patients with hepatocellular carcinoma who underwent liver resection. METHODS: Patients with hepatocellular carcinoma who underwent liver resection between 2009 and 2019 at Kobe University Hospital and Hyogo Cancer Center were included. After propensity score matching between the bile leak and no bile leak groups, differences in 5-year recurrence-free and overall survival rates were evaluated using the Kaplan-Meier method. RESULTS: A total of 781 patients, including 43 with postoperative bile leak, were analyzed. In the matched cohort, 40 patients were included in each group. The 5-year recurrence-free survival rates after liver resection were 35% and 32% for the bile leak and no bile leak groups, respectively (P = 0.857). The 5-year overall survival rates were 44% and 54% for the bile leak and no bile leak groups, respectively (P = 0.216). CONCLUSION: Overall, bile leak may not have a profound negative impact on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection.

  Jul. 2024, Langenbeck's archives of surgery, 409(1) (1), 233 - 233, English, International magazine

  Scientific journal


• Complete response to tremelimumab plus durvalumab treatment in hepatocellular carcinoma with a bile duct tumor thrombus: A case report.

  Nobuaki Ishihara, Shohei Komatsu, Masahiro Kido, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Toshihiko Yoshida, Keisuke Arai, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto

  Tremelimumab plus durvalumab (Dur/Tre) is the first-line treatment for advanced hepatocellular carcinoma (HCC) worldwide. The present report describes the case of a 68-year-old man diagnosed with advanced HCC and a bile duct tumor thrombus (BDTT) who achieved a complete response to Dur/Tre therapy. The BDTT progressed to the bifurcation of the left and right hepatic ducts. Over time, both the tumors and BDTT progressively decreased in size, and a complete response was confirmed using the Response Evaluation Criteria in Solid Tumors (version 1.1.) 6 months after treatment administration. Subsequently, immune-related adverse events, including type 1 diabetes mellitus and diabetic ketoacidosis, emerged, leading to treatment discontinuation. The patient was undergoing outpatient follow-up in a drug-free state with no signs of recurrence 290 days after the initial administration of Dur/Tre. Although long-term and meticulous observations are required, the present findings could influence the choice of systemic chemotherapy for advanced HCC.

  Jul. 2024, Oncology letters, 28(1) (1), 332 - 332, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Current Roles of Ramucirumab in the Sequential Treatment of Unresectable Hepatocellular Carcinoma.

  Akira Koizumi, Shohei Komatsu, Satoshi Omiya, Yoshihiko Yano, Yoshimi Fujishima, Jun Ishida, Masahiro Kido, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Shinichi So, Toshihiko Yoshida, Keisuke Arai, Ryosuke Fujinaka, Yuhi Shimura, Hiroaki Yanagimoto, Hirochika Toyama, Yoshihide Ueda, Yuzo Kodama, Takumi Fukumoto

  BACKGROUND/AIM: The treatment algorithm for systemic therapies for advanced hepatocellular carcinoma (HCC) has changed dramatically; however, the therapeutic landscape for sequential second-line or later-line treatments, including ramucirumab, remains controversial. This study aimed to investigate the role of ramucirumab for treating HCC. PATIENTS AND METHODS: We retrospectively analyzed data from 17 patients with advanced HCC who received ramucirumab, and 8 of them who received lenvatinib re-administration after ramucirumab treatment failure. RESULTS: The median overall survival of 17 patients treated with ramucirumab was 11.5 months. The median ratios of the 1-month post-treatment α-fetoprotein (AFP) levels and albumin-bilirubin (ALBI) scores to the pre-treatment AFP levels and ALBI scores following ramucirumab treatment were 0.880 and 0.965, respectively. The median ratios of the 1-month post-treatment AFP and ALBI levels to the pre-treatment levels were 1.587 and 0.970 for mALBI grade 1/2a, and 1.313 and 0.936 for mALBI grade 2b/3, respectively. Six of the eight patients who received lenvatinib rechallenge treatment exhibited a decrease in AFP levels one month post-lenvatinib treatment. Deterioration of liver function 3 months post-lenvatinib treatment was noted in five of the eight patients who received lenvatinib rechallenge treatment after ramucirumab. CONCLUSION: Ramucirumab may be equally useful in patients with unresectable HCC who have poor liver function or whose liver function is aggravated by other therapies. Rechallenge treatment with lenvatinib after ramucirumab may be a valid treatment option for HCC.

  May 2024, Anticancer research, 44(5) (5), 2055 - 2061, English, International magazine

  Scientific journal


• The Albumin-bilirubin Grade as Prognostic Indicator for Recurrent Hepatocellular Carcinoma Needing Repeat Liver Resection.

  Hidetoshi Gon, Shohei Komatsu, Satoshi Omiya, Masahiro Kido, Kenji Fukushima, Takeshi Urade, Toshihiko Yoshida, Keisuke Arai, Jun Ishida, Yoshihide Nanno, Daisuke Tsugawa, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto

  BACKGROUND/AIM: This study aimed to evaluate the utility of the albumin-bilirubin grade for predicting the prognosis after repeat liver resection for patients with recurrent hepatocellular carcinoma. PATIENTS AND METHODS: Ninety patients with intrahepatic recurrent hepatocellular carcinoma who underwent repeat liver resection at our institution between 2005 and 2019 were retrospectively analyzed. Cox proportional-hazards regression models evaluated independent preoperative prognostic factors, including the albumin-bilirubin grade. Prognosis differences between patients with albumin-bilirubin grades 1 and 2 were analyzed using the Kaplan-Meier method. RESULTS: Cox proportional-hazards regression analysis revealed that albumin-bilirubin grade 2 (p=0.003) and early recurrence within one year from the initial surgery (p=0.001) were independently associated with poor recurrence-free survival, and albumin-bilirubin grade 2 (p=0.020) was independently associated with poor overall survival. The five-year recurrence-free (31% and 17%, respectively) and overall (86% and 60%, respectively) survival rates after repeat liver resection for patients with albumin-bilirubin grades 1 and 2 were significantly different between groups (both p=0.003). CONCLUSION: The albumin-bilirubin grade is useful for preoperatively predicting favorable survival rates after repeat liver resection for patients with recurrent hepatocellular carcinoma. Patients with an albumin-bilirubin grade 1 are better candidates for surgical treatment of recurrent hepatocellular carcinoma.

  May 2024, Anticancer research, 44(5) (5), 2031 - 2038, English, International magazine

  Scientific journal


• Optimal cutoff values of drain amylase for predicting pancreatic fistula are different between open and laparoscopic distal pancreatectomy.

  Jun Ishida, Hirochika Toyama, Sadaki Asari, Tadahiro Goto, Yoshihide Nanno, Toshihiko Yoshida, Shinichi So, Takeshi Urade, Kenji Fukushima, Hidetoshi Gon, Daisuke Tsugawa, Shohei Komatsu, Hiroaki Yanagimoto, Masahiro Kido, Takumi Fukumoto

  BACKGROUND: Drainage fluid amylase (DFA) is useful for predicting clinically relevant postoperative pancreatic fistula (CR-POPF) after distal pancreatectomy (DP). However, difference in optimal cutoff value of DFA for predicting CR-POPF between open DP (ODP) and laparoscopic DP (LDP) has not been investigated. This study aimed to identify the optimal cutoff values of DFA for predicting CR-POPF after ODP and LDP. METHODS: Data for 294 patients (ODP, n = 127; LDP, n = 167) undergoing DP at Kobe University Hospital between 2010 and 2021 were reviewed. Propensity score matching was performed to minimize treatment selection bias. Receiver operating characteristic (ROC) analysis was performed to determine the optimal cutoff values of DFA for predicting CR-POPF for ODP and LDP. Logistic regression analysis for CR-POPF was performed to investigate the diagnostic value of DFA on postoperative day (POD) three with identified cutoff value. RESULTS: In the matched cohort, CR-POPF rates were 24.7% and 7.9% after ODP and LDP, respectively. DFA on POD one was significantly lower after ODP than after LDP (2263 U/L vs 4243 U/L, p < 0.001), while the difference was not significant on POD three (543 U/L vs 1221 U/L, p = 0.171). ROC analysis revealed that the optimal cutoff value of DFA on POD one and three for predicting CR-POPF were different between ODP and LDP (ODP, 3697 U/L on POD one, 1114 U/L on POD three; LDP, 10564 U/L on POD one, 6020 U/L on POD three). Multivariate analysis showed that DFA on POD three with identified cutoff value was the independent predictor for CR-POPF both for ODP and LDP. CONCLUSIONS: DFA on POD three is an independent predictor for CR-POPF after both ODP and LDP. However, the optimal cutoff value for it is significantly higher after LDP than after ODP. Optimal threshold of DFA for drain removal may be different between ODP and LDP.

  Mar. 2024, Surgical endoscopy, 38(5) (5), 2699 - 2708, English, International magazine

  Scientific journal


• Utility of plasma D-dimer for diagnosis of venous thromboembolism after hepatectomy.

  Taiichiro Miyake, Hiroaki Yanagimoto, Daisuke Tsugawa, Masayuki Akita, Riki Asakura, Keisuke Arai, Toshihiko Yoshida, Shinichi So, Jun Ishida, Takeshi Urade, Yoshihide Nanno, Kenji Fukushima, Hidetoshi Gon, Shohei Komatsu, Sadaki Asari, Hirochika Toyama, Masahiro Kido, Tetsuo Ajiki, Takumi Fukumoto

  BACKGROUND: Venous thromboembolism (VTE) is a potentially fatal complication of hepatectomy. The use of postoperative prophylactic anticoagulation in patients who have undergone hepatectomy is controversial because of the risk of postoperative bleeding. Therefore, we hypothesized that monitoring plasma D-dimer could be useful in the early diagnosis of VTE after hepatectomy. AIM: To evaluate the utility of monitoring plasma D-dimer levels in the early diagnosis of VTE after hepatectomy. METHODS: The medical records of patients who underwent hepatectomy at our institution between January 2017 and December 2020 were retrospectively analyzed. Patients were divided into two groups according to whether or not they developed VTE after hepatectomy, as diagnosed by contrast-enhanced computed tomography and/or ultrasonography of the lower extremities. Clinicopathological factors, including demographic data and perioperative D-dimer values, were compared between the two groups. Receiver operating characteristic curve analysis was performed to determine the D-dimer cutoff value. Univariate and multivariate analyses were performed using logistic regression analysis to identify significant predictors. RESULTS: In total, 234 patients who underwent hepatectomy were, of whom (5.6%) were diagnosed with VTE following hepatectomy. A comparison between the two groups showed significant differences in operative time (529 vs 403 min, P = 0.0274) and blood loss (530 vs 138 mL, P = 0.0067). The D-dimer levels on postoperative days (POD) 1, 3, 5, 7 were significantly higher in the VTE group than in the non-VTE group. In the multivariate analysis, intraoperative blood loss of > 275 mL [odds ratio (OR) = 5.32, 95% confidence interval (CI): 1.05-27.0, P = 0.044] and plasma D-dimer levels on POD 5 ≥ 21 μg/mL (OR = 10.1, 95%CI: 2.04-50.1, P = 0.0046) were independent risk factors for VTE after hepatectomy. CONCLUSION: Monitoring of plasma D-dimer levels after hepatectomy is useful for early diagnosis of VTE and may avoid routine prophylactic anticoagulation in the postoperative period.

  Jan. 2024, World journal of clinical cases, 12(2) (2), 276 - 284, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Efficacy and safety of laparoscopic liver resection for hepatocellular carcinoma in segment 8: a propensity score-matched two-center study.

  Nobuaki Yamasaki, Hidetoshi Gon, Hisoka Yamane, Toshihiko Yoshida, Hirotoshi Soyama, Masahiro Kido, Motofumi Tanaka, Shohei Komatsu, Daisuke Tsugawa, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto

  BACKGROUND: The safety and efficacy of laparoscopic liver resection (LLR) have been reported worldwide. However, those of LLR for tumors located in Couinaud's segment 8 are not sufficiently investigated. METHODS: We retrospectively analyzed 108 patients who underwent liver resection for hepatocellular carcinoma (HCC) in segment 8 at Kobe University Hospital and Hyogo Cancer Center between January 2010 and December 2021. The patients were categorized in LLR and open liver resection (OLR) groups, and 1:1 propensity score matching (PSM) was performed to compare surgical outcomes between the groups. RESULTS: Forty-seven and 61 patients underwent LLR and OLR, respectively. After PSM, each group contained 34 patients. There was no significant difference in operation time between the groups (331 min vs. 330 min, P = 0.844). Patients in the LLR group had significantly less blood loss (30 mL vs. 468 mL, P < 0.001) and shorter length of postoperative hospital stay (10 days vs. 12 days, P = 0.015) than those in the OLR group. There was no significant difference in the occurrence of postoperative complications between the groups (12% vs. 9%, P = 0.690). Further, the 1-year cumulative incidence of recurrence was not significantly different between the groups (16% vs. 19%, P = 0.734). CONCLUSIONS: The surgical outcomes and short-term prognosis of LLR were similar or better than those of OLR. LLR could be an effective and safe procedure, even for lesions located in segment 8, which is considered a difficult anatomical location for LLR.

  Nov. 2023, Surgical endoscopy, 37(11) (11), 8438 - 8446, English, International magazine

  Scientific journal


• Advantages of the Laparoscopic Approach for the Initial Operation in Patients who Underwent Repeat Hepatectomy.

  Hidetoshi Gon, Shohei Komatsu, Masahiro Kido, Kenji Fukushima, Takeshi Urade, Shinichi So, Toshihiko Yoshida, Keisuke Arai, Jun Ishida, Yoshihide Nanno, Daisuke Tsugawa, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto

  BACKGROUND: Less intra-abdominal adhesions are expected following laparoscopic surgery. Although an initial laparoscopic approach for primary liver tumors may have advantages in patients who require repeat hepatectomies for recurrent liver tumors, this has not been sufficiently investigated. METHODS: Patients who underwent repeat hepatectomies for recurrent liver tumors at our hospital between 2010 and 2022 were retrospectively analyzed. Of 127 patients, 76 underwent laparoscopic repeat hepatectomy (LRH), of whom 34 patients initially underwent laparoscopic hepatectomy (L-LRH) and 42, open hepatectomy (O-LRH). Fifty-one patients underwent open hepatectomy as both the initial and second operation (O-ORH). We analyzed surgical outcomes between L-LRH and O-LRH groups and between L-LRH and O-ORH groups using propensity-matching analysis for each pattern. RESULTS: Twenty-one patients each were included in L-LRH and O-LRH propensity-matched cohorts. The L-LRH group had a lower rate of postoperative complications than the O-LRH group (0 vs 19%, P = 0.036). When we compared surgical outcomes between L-LRH and O-ORH groups in another matched cohort with 18 patients in each group, in addition to the lower rate of postoperative complications, the L-LRH group had additional favorable surgical outcomes including shorter operation time and lower blood loss volume than the O-ORH group (291 vs 368 min, P = 0.037 and 10 vs 485 mL, P < 0.0001). CONCLUSIONS: An initial laparoscopic approach would be favorable for patients undergoing repeat hepatectomies, as it leads to lower risk of postoperative complications. Compared with O-ORH, the advantage of the laparoscopic approach may be enhanced when it is repeatedly adopted.

  Aug. 2023, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 27(8) (8), 1621 - 1631, English, International magazine

  Scientific journal


• Factors Predicting Over-Time Weight Increase After Liver Transplantation: A Retrospective Study.

  Yuhi Shimura, Kaori Kuramitsu, Masahiro Kido, Shohei Komatsu, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Shinichi So, Toshihiko Yoshida, Keisuke Arai, Daisuke Tsugawa, Tadahiro Goto, Sadaki Asari, Hiroaki Yanagimoto, Hirochika Toyama, Tetsuo Ajiki, Takumi Fukumoto

  BACKGROUND: Post-transplantation weight control is important for long-term outcomes; however, few reports have examined postoperative weight change. This study aimed to identify perioperative factors contributing to post-transplantation weight change. METHODS: Twenty-nine patients who underwent liver transplantation between 2015 and 2019 with an overall survival of >3 years were analyzed. RESULTS: The median age, model for end-stage liver disease score, and preoperative body mass index (BMI) of the recipients were 57, 25, and 23.7, respectively. Although all but one recipient lost weight, the percentage of recipients who gained weight increased to 55% (1 month), 72% (6 months), and 83% (12 months). Among perioperative factors, recipient age ≤50 years and BMI ≤25 were identified as risk factors for weight gain within 12 months (P < .05), and patients with age ≤50 years or BMI ≤25 recipients gained weight more rapidly (P < .05). The recovery time of serum albumin level ≥4.0 mg/dL was not statistically different between the 2 groups. The weight change during the first 3 years after discharge was represented by an approximately straight line, with 18 and 11 recipients showing a positive and negative slope, respectively. Body mass index ≤23 was identified as a risk factor for a positive slope of weight gain (P <.05). CONCLUSIONS: Although postoperative weight gain implies recovery after transplantation, recipients with a lower preoperative BMI should strictly manage body weight as they may be at higher risk of rapid weight increase.

  May 2023, Transplantation proceedings, 55(4) (4), 924 - 929, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• ロボット支援下腹会陰式直腸切断術後に8mmポートサイトヘルニアを発症した1例

  古谷 晃伸, 福岡 英志, 毛利 康一, 吉田 俊彦, 秋山 真吾, 山岸 農, 村田 晃一, 大坪 大, 山根 秘我, 沢 秀博, 田中 基文, 鈴木 知志, 藤野 泰宏, 富永 正寛

  (株)癌と化学療法社, Feb. 2023, 癌と化学療法, 50(2) (2), 221 - 223, Japanese


• Antibody responses and SARS-CoV-2 infection after BNT162b2 mRNA booster vaccination among healthcare workers in Japan.

  Hidetoshi Igari, Haruna Asano, Shota Murata, Toshihiko Yoshida, Kenji Kawasaki, Takahiro Kageyama, Key Ikeda, Hiromi Koshikawa, Yoshio Okuda, Misao Urushihara, Hitoshi Chiba, Misuzu Yahaba, Toshibumi Taniguchi, Kazuyuki Matsushita, Ichiro Yoshino, Koutaro Yokote, Hiroshi Nakajima

  INTRODUCTION: Vaccine effectiveness against SARS-CoV-2 infections decreases due to waning immunity, and booster vaccination was therefore introduced. We estimated the anti-spike antibody (AS-ab) recovery by booster vaccination and analyzed the risk factors for SARS-CoV-2 infections. METHODS: The subjects were health care workers (HCWs) in a Chiba University Hospital vaccination cohort. They had received two doses of vaccine (BNT162b2) and a booster vaccine (BNT162b2). We retrospectively analyzed AS-ab titers and watched out for SARS-CoV-2 infection for 90 days following booster vaccination. RESULTS: AS-ab titer eight months after two-dose vaccinations had decreased to as low as 587 U/mL (median, IQR (interquartile range) 360-896). AS-ab titer had then increased to 22471 U/mL (15761-32622) three weeks after booster vaccination. There were no significant differences among age groups. A total of 1708 HCWs were analyzed for SARS-CoV-2 infection, and 48 of them proved positive. SARS-CoV-2 infections in the booster-vaccinated and non-booster groups were 1.8% and 4.0%, respectively, and were not significant. However, when restricted to those 20-29 years old, SARS-CoV-2 infections in the booster-vaccinated and non-booster groups were 2.9% and 13.6%, respectively (p = 0.04). After multivariate logistic regression, COVID-19 wards (adjusted odds ratio (aOR):2.9, 95% confidence interval (CI) 1.5-5.6) and those aged 20-49 years (aOR:9.7, 95%CI 1.3-71.2) were risk factors for SARS-CoV-2 infection. CONCLUSIONS: Booster vaccination induced the recovery of AS-ab titers. Risk factors for SARS-CoV-2 infection were HCWs of COVID-19 wards and those aged 20-49 years. Increased vaccination coverage, together with implementing infection control, remains the primary means of preventing HCWs from SARS-CoV-2 infection.

  Nov. 2022, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 28(11) (11), 1483 - 1488, English, International magazine

  Scientific journal


• Suitability of Laparoscopic Liver Resection of Segment VII: a Retrospective Two-Center Study.

  Hidetoshi Gon, Hisoka Yamane, Toshihiko Yoshida, Masahiro Kido, Motofumi Tanaka, Kaori Kuramitsu, Shohei Komatsu, Kenji Fukushima, Takeshi Urade, Shinichi So, Yoshihide Nanno, Daisuke Tsugawa, Tadahiro Goto, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto

  BACKGROUND: Resecting liver tumors located in Couinaud's segment VII is challenging; the efficacy and safety of laparoscopic liver resection for segment VII lesions compared to open liver resection remain unclear. METHODS: Medical records of 84 patients who underwent liver resection of segment VII at Kobe University Hospital and Hyogo Cancer Center between 2010 and 2021 were retrospectively analyzed. Surgical outcomes were compared between laparoscopic liver resection and open liver resection groups using propensity matching analysis. RESULTS: Thirty-one and 53 patients underwent laparoscopic liver resection and open liver resection, respectively. After propensity matching, 29 patients were included in each group. The laparoscopic liver resection group had a significantly longer operation time (407 vs. 305 min, P = 0.002), lower blood loss (100 vs. 230 mL, P = 0.004), and higher postoperative alanine aminotransferase levels (436 vs. 252 IU/L, P = 0.008) than the open liver resection group. In patients with liver cirrhosis, the proportion of patients with postoperative liver-specific complications was higher in the laparoscopic liver resection group than in the open liver resection group (57% vs 11%, P = 0.049), although there was no significant difference in postoperative liver-specific complication rates between the groups in patients without liver cirrhosis. CONCLUSIONS: For liver resection of segment VII, laparoscopic liver resection led to higher postoperative liver damage than open liver resection. Open liver resection may be better for patients with liver cirrhosis to avoid postoperative liver-specific complications. Laparoscopic liver resection could be an acceptable procedure for patients without liver cirrhosis, with some merits such as less blood loss.

  Nov. 2022, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 26(11) (11), 2274 - 2281, English, International magazine

  Scientific journal


• A case of intraductal papillary neoplasm of the bile duct accompanied by intraductal papillary mucinous neoplasm of the pancreas and hepatocellular carcinoma.

  Takumi Kitahama, Hisoka Yamane, Koichi Mohri, Eiji Fukuoka, Toshihiko Yoshida, Takashi Yamagishi, Hironobu Goto, Akinobu Furutani, Dai Otsubo, Taku Matsumoto, Motofumi Tanaka, Yasuhiro Fujino, Masahiro Tominaga

  A 73-year-old man with mixed-type intraductal papillary mucinous neoplasm of the pancreas body was followed up for 14 years. Based on imaging findings, the intraductal papillary mucinous neoplasm of the pancreas met the high-risk stigmata, and new hepatic masses were suspected to be intraductal papillary neoplasms of the bile duct. With a diagnosis of intraductal papillary mucinous neoplasm of the pancreas and intraductal papillary neoplasm of the bile duct, the patient had undergone left lateral hepatectomy and distal pancreatectomy. Based on pathology, the pancreatic specimen was diagnosed as a high-grade intraductal papillary mucinous neoplasm of the pancreas, and the hepatic specimen was diagnosed as an intraductal papillary neoplasm of the bile duct and hepatocellular carcinoma. The intraductal papillary neoplasms of the bile duct and hepatocellular carcinoma were adjacent to each other. Fifteen months after surgery, recurrence in the remnant pancreas was detected. The patient had undergone residual total pancreatectomy, with no recurrence thirty months after the second resection. This case demonstrates that second surgery for metachronous high-risk lesions in the remnant pancreas of patients with intraductal papillary mucinous neoplasm of the pancreas and intraductal papillary neoplasm of the bile duct may also be considered to improve survival.

  Oct. 2021, Clinical journal of gastroenterology, 14(5) (5), 1536 - 1543, English, Domestic magazine

  Scientific journal


• Hepatocellular carcinoma recurrence in the extrahepatic bile duct wall: A case report.

  Taku Matsumoto, Toshihiko Yoshida, Takashi Yamagishi, Hironobu Goto, Dai Otsubo, Akinobu Furutani, Hisoka Yamane, Yasuhiro Fujino, Masahiro Tominaga

  We should know that hepatocellular carcinoma can progress as if it replaces the bile duct wall itself.

  Mar. 2021, Clinical case reports, 9(3) (3), 1561 - 1565, English, International magazine

  Scientific journal


• A case of laparoscopic anterior resection for rectal cancer with duplication of the inferior vena cava using preoperative 3D computed tomography angiography.

  Akinobu Furutani, Sachiko Yoshida, Toshihiko Yoshida, Masayasu Nishi, Takashi Yamagishi, Hironobu Goto, Dai Otsubo, Hisoka Yamane, Taku Matsumoto, Yasuhiro Fujino, Masahiro Tominaga

  We report the case of a patient with duplication of the inferior vena cava (DIVC) who underwent anterior laparoscopic resection for rectal cancer. A 66-year-old woman presented with abnormal lung shadows on a chest x-ray during a routine health checkup. She was diagnosed with rectal cancer and lung metastasis using colonoscopy and thoracoabdominal computed tomography (CT). In addition, a 3D CT angiography revealed double inferior vena cava, one on either side of the aorta. The preoperative diagnosis was rectal cancer cT3N0M1a(Lung) cStage IVA with DIVC, and a two-stage surgery was planned. The first stage was high anterior laparoscopic resection. This was safely performed because the pre-hypogastric nerve fascia was preserved and the left inferior vena cava was not visualized during the surgery. During the second stage of the surgery, video-assisted thoracoscopic left lower lobectomy was performed and no recurrence was observed for >6 months after the second surgery.

  Sep. 2020, Journal of surgical case reports, 2020(9) (9), rjaa223, English, International magazine

  Scientific journal


• Novel biodegradable magnesium alloy clips compared with titanium clips for hepatectomy in a rat model.

  Takeshi Urade, Toshihiko Yoshida, Naoko Ikeo, Kosuke Naka, Masahiro Kido, Hirochika Toyama, Kimihiko Ueno, Motofumi Tanaka, Toshiji Mukai, Takumi Fukumoto

  BACKGROUND: The use of surgical metal clips is crucial for ligating vessels in various operations. The currently available metal clips have several drawbacks; they are permanent and interfere with imaging techniques such as computed tomography (CT) or magnetic resonance (MR) imaging and carry the potential risk of endo-clip migration. We recently developed a novel magnesium (Mg) alloy for biodegradable clips that reduces artifacts on CT imaging. This study aimed to examine the tolerance, biodegradability, and biocompatibility of the Mg alloy clips compared with those of standard titanium (Ti) clips in hepatectomy. METHODS: Thirty Wistar rats were divided into two groups based on the clip used (groups A and B). The vascular pedicle, including hepatic artery, portal vein, bile duct, and hepatic vein of the left lateral lobe, was ligated with the Ti clip in group A or the Mg alloy clip in group B, and then the left lateral lobe was removed. The rats were sacrificed at 1, 4, 12, 24, and 36 weeks after surgery. Clinical and histological evaluations were performed. Absorption rate was calculated by measuring the clip volume. RESULTS: Although the Mg alloy clips showed biodegradability over time, there were no significant differences in the serum concentration of Mg between the two groups. The remaining volume ratio of Mg alloy clips was 95.5, 94.3, 80.0, 36.2, and 16.7% at 1, 4, 12, 24, and 36 weeks, respectively. No side effects occurred. Most of the microscopic changes were similar in both groups. CONCLUSIONS: The new biodegradable Mg alloy clips are safe and feasible in vessel ligation for hepatectomy in a rat model and reduce artifacts in CT imaging compared with the standard Ti clips.

  Sep. 2019, BMC surgery, 19(1) (1), 130 - 130, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Laparoscopic anatomical segment 3 segmentectomy for hepatocellular carcinoma accompanied by hypoplasia of the right hepatic lobe.

  Hisoka Yamane, Sachiko Yoshida, Toshihiko Yoshida, Masayasu Nishi, Takashi Yamagishi, Hironobu Goto, Dai Otsubo, Akinobu Furutani, Taku Matsumoto, Yasuhiro Fujino, Masahiro Tominaga

  We report a case of laparoscopic anatomical segment 3 segmentectomy for hepatocellular carcinoma (HCC) accompanied by hypoplasia of the right hepatic lobe. An 80-year-old man was admitted with a suspicion of HCC diagnosed by computed tomography during follow-up for thyroid cancer. Dynamic computed tomography showed 40-mm HCC in segment 3 and hypoplasia of the right hepatic lobe with the Chilaiditi sign. We performed laparoscopic anatomical segment 3 segmentectomy. There were no postoperative complications, and the patient was discharged 6 days postoperatively. This procedure can be performed safely and is technically feasible, but special attention should be paid to anatomical alterations to avoid fatal surgical complications.

  Jul. 2019, Journal of surgical case reports, 2019(7) (7), rjz213, English, International magazine

  Scientific journal


• Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth.

  Takeshi Harada, Shinji Matsumoto, Suguru Hirota, Hirokazu Kimura, Shinsuke Fujii, Yuuya Kasahara, Hidetoshi Gon, Toshihiko Yoshida, Tomoo Itoh, Naotsugu Haraguchi, Tsunekazu Mizushima, Takehiro Noda, Hidetoshi Eguchi, Satoshi Nojima, Eiichi Morii, Takumi Fukumoto, Satoshi Obika, Akira Kikuchi

  ADP-ribosylation factor-like 4c (ARL4C) is identified as a small GTP-binding protein, which is expressed by Wnt and EGF signaling and plays an important role in tubulogenesis of cultured cells and the ureters. ARL4C is little expressed in adult tissues, but it is highly expressed in lung cancer and colorectal cancer and shown to represent a molecular target for cancer therapy based on siRNA experiments. This study revealed that ARL4C is highly expressed in primary hepatocellular carcinoma (HCC) tumors and colorectal cancer liver metastases, and that ARL4C expression is associated with poor prognosis for these cancers. Chemically modified antisense oligonucleotides (ASO) against ARL4C effectively reduced ARL4C expression in both HCC and colorectal cancer cells and inhibited proliferation and migration of these cancer cells in vitro ARL4C ASOs decreased the PIK3CD mRNA levels and inhibited the activity of AKT in HCC cells, suggesting that the downstream signaling of ARL4C in HCC cells is different from that in lung and colon cancer cells. In addition, subcutaneous injection of ARL4C ASO was effective in reducing the growth of primary HCC and metastatic colorectal cancer in the liver of immunodeficient mice. ARL4C ASO accumulated in cancer cells more efficiently than the surrounding normal cells in the liver and decreased ARL4C expression in the tumor. These results suggest that ARL4C ASO represents a novel targeted nucleic acid medicine for the treatment of primary and metastatic liver cancers.

  Mar. 2019, Molecular cancer therapeutics, 18(3) (3), 602 - 612, English, International magazine

  Scientific journal


• Laparoscopic hepatectomy for liver metastasis of lung large-cell neuroendocrine carcinoma: A case report.

  Hisoka Yamane, Sachiko Yoshida, Toshihiko Yoshida, Masayasu Nishi, Takashi Yamagishi, Hironobu Goto, Dai Otsubo, Akinobu Furutani, Taku Matsumoto, Yasuhiro Fujino, Kazuyoshi Kajimoto, Toshiko Sakuma, Masahiro Tominaga

  INTRODUCTION: Lung large-cell neuroendocrine carcinoma (LCNEC) is an aggressive and a rare type of lung cancer, and the prognosis of LCNEC with distant metastasis is extremely poor, with a five-year survival rate of 0%. Here, we report a case of laparoscopic hepatectomy for liver metastasis of lung LCNEC. PRESENTATION OF CASE: A 63-year-old man received a routine physical examination, and abnormal chest radiographic findings were observed; chest computed tomography (CT) in our hospital revealed that the patient had left pneumothorax and a lesion measuring 18 mm in the inferior lingular segment of the lung. The patient underwent thoracoscopic lobectomy, and the final pathological diagnosis was lung LCNEC. Four years after surgery, abdominal CT revealed a mass measuring 27 mm in the liver. The patient underwent laparoscopic partial hepatectomy, and postoperative pathological examination showed liver metastasis of LCNEC. There was no sign of recurrence 6 months after hepatectomy. DISCUSSION: LCNEC with distant metastasis has a poor response to systemic chemotherapy, and the median survival time of patients with distant metastasis is estimated to be approximately 6 months, with a five-year survival rate of 0%. Although the common site of metastasis from LCNEC is the liver, there are no previous reports of hepatectomy for liver metastasis of LCNEC. CONCLUSION: We report a case of laparoscopic hepatectomy for liver metastasis of lung LCNEC. It is suggested that surgical resection for solitary distant metastasis of LCNEC may improve prognosis.

  2019, International journal of surgery case reports, 65, 40 - 43, English, International magazine

  Scientific journal


• Development of a simple indocyanine green measurement method using an automated biochemical analyser.

  Yuka Sato, Masanori Seimiya, Toshihiko Yoshida, Yuji Sawabe, Eisaku Hokazono, Susumu Osawa, Kazuyuki Matsushita

  Background The indocyanine green retention rate is important for assessing the severity of liver disorders. In the conventional method, blood needs to be collected twice. In the present study, we developed an automated indocyanine green method that does not require blood sampling before intravenous indocyanine green injections and is applicable to an automated biochemical analyser. Methods The serum samples of 471 patients collected before and after intravenous indocyanine green injections and submitted to the clinical laboratory of our hospital were used as samples. The standard procedure established by the Japan Society of Hepatology was used as the standard method. In the automated indocyanine green method, serum collected after an intravenous indocyanine green injection was mixed with the saline reagent containing a surfactant, and the indocyanine green concentration was measured at a dominant wavelength of 805 nm and a complementary wavelength of 884 nm. Results The coefficient of variations of the within- and between-run reproducibilities of this method were 2% or lower, and dilution linearity passing the origin was noted up to 10 mg/L indocyanine green. The reagent was stable for four weeks or longer. Haemoglobin, bilirubin and chyle had no impact on the results obtained. The correlation coefficient between the standard method (x) and this method (y) was r=0.995; however, slight divergence was noted in turbid samples. Conclusion Divergence in turbid samples may have corresponded to false negativity with the standard procedure. Our method may be highly practical because blood sampling before indocyanine green loading is unnecessary and measurements are simple.

  Jul. 2018, Annals of clinical biochemistry, 55(4) (4), 491 - 495, English, International magazine

  Scientific journal


• 消化器外科の診断・手技・治療に役立つ先進技術 マグネシウム合金を用いた新規生体吸収性外科クリップの開発 イヌ胆嚢摘出モデルでの安全性と忍容性の検討

  吉田 俊彦, 福本 巧, 浦出 剛史, 木戸 正浩, 外山 博近, 浅利 貞毅, 味木 徹夫, 池尾 直子, 向井 敏司, 具 英成

  (一社)日本消化器外科学会, Jul. 2017, 日本消化器外科学会総会, 72回, O3 - 6, Japanese


• Development of a new biodegradable operative clip made of a magnesium alloy: Evaluation of its safety and tolerability for canine cholecystectomy.

  Toshihiko Yoshida, Takumi Fukumoto, Takeshi Urade, Masahiro Kido, Hirochika Toyama, Sadaki Asari, Tetsuo Ajiki, Naoko Ikeo, Toshiji Mukai, Yonson Ku

  BACKGROUND: Operative clips used to ligate vessels in abdominal operation usually are made of titanium. They remain in the body permanently and form metallic artifacts in computed tomography images, which impair accurate diagnosis. Although biodegradable magnesium instruments have been developed in other fields, the physical properties necessary for operative clips differ from those of other instruments. We developed a biodegradable magnesium-zinc-calcium alloy clip with good biologic compatibility and enough clamping capability as an operative clip. In this study, we verified the safety and tolerability of this clip for use in canine cholecystectomy. METHODS: Nine female beagles were used. We performed cholecystectomy and ligated the cystic duct by magnesium alloy or titanium clips. The chronologic change of clips and artifact formation were compared at 1, 4, 12, 18, and 24 weeks postoperative by computed tomography. The animals were killed at the end of the observation period, and the clips were removed to evaluate their biodegradability. We also evaluated their effect on the living body by blood biochemistry data. RESULTS: The magnesium alloy clip formed much fewer artifacts than the titanium clip, and it was almost absorbed at 6 months postoperative. There were no postoperative complications and no elevation of constituent elements such as magnesium, calcium, and zinc during the observation period in both groups. CONCLUSION: The novel magnesium alloy clip demonstrated sufficient sealing capability for the cystic duct and proper biodegradability in canine models. The magnesium alloy clip revealed much fewer metallic artifacts in CT than the conventional titanium clip.

  Jun. 2017, Surgery, 161(6) (6), 1553 - 1560, English, International magazine

  Scientific journal


• Wetting Induced Oxidation of Pt-based Nano Catalysts Revealed by In Situ High Energy Resolution X-ray Absorption Spectroscopy.

  Yi-Tao Cui, Yoshihisa Harada, Hideharu Niwa, Tatsuya Hatanaka, Naoki Nakamura, Masaki Ando, Toshihiko Yoshida, Kenji Ishii, Daiju Matsumura, Hiroshi Oji, Hironori Ofuchi, Masaharu Oshima

  In situ high energy resolution fluorescence detection X-ray absorption spectroscopy (HERFD-XAS) was used to systematically evaluate interactions of H2O and O2 adsorbed on Pt and Pt3Co nanoparticle catalysts in different particle sizes. The systematic increase in oxidation due to adsorption of different species (H2O adsorption May 2017, Scientific reports, 7(1) (1), 1482 - 1482, English, International magazine

  Scientific journal


• 新規マグネシウム合金を用いた生体吸収性外科クリップの開発

  吉田 俊彦, 福本 巧, 味木 徹夫, 木戸 正浩, 外山 博近, 浅利 貞毅, 浦出 剛史, 池尾 直子, 向井 敏司, 具 英成

  (一社)日本消化器外科学会, Jul. 2016, 日本消化器外科学会総会, 71回, P1 - 10, Japanese


• Low-Dose Antiviral Treatment for Hepatitis C Virus Following Living Donor Liver Transplantation without Splenectomy

  Toshihiko Yoshida, Atsushi Takebe, Takumi Fukumoto, Masahiro Kido, Motofumi Tanaka, Kaori Kuramitsu, Hisoka Kinoshita, Shinichi So, Keisuke Arai, Yonson Ku

  May 2016, TRANSPLANTATION, 100, S211 - S211, English


• Fabrication of a magnesium alloy with excellent ductility for biodegradable clips.

  Naoko Ikeo, Ryota Nakamura, Kosuke Naka, Toshiaki Hashimoto, Toshihiko Yoshida, Takeshi Urade, Kenji Fukushima, Hikaru Yabuuchi, Takumi Fukumoto, Yonson Ku, Toshiji Mukai

  UNLABELLED: To develop a biodegradable clip, the equivalent plastic strain distribution during occlusion was evaluated by the finite element analysis (FEA) using the material data of pure Mg. Since the FEA suggested that a maximum plastic strain of 0.40 is required to allow the Mg clips, the alloying of magnesium with essential elements and the control of microstructure by hot extrusion and annealing were conducted. Mechanical characterization revealed that the Mg-Zn-Ca alloy obtained by double extrusion followed by annealing at 673K for 2h possessed a fracture strain over 0.40. The biocompatibility of the alloy was confirmed here by investigating its degradation behavior and the response of extraperitoneal tissue around the Mg-Zn-Ca alloy. Small gas cavity due to degradation was observed following implantation of the developed Mg-Zn-Ca clip by in vivo micro-CT. Histological analysis, minimal observed inflammation, and an only small decrease in the volume of the implanted Mg-Zn-Ca clip confirmed its excellent biocompatibility. FEA using the material data for ductile Mg-Zn-Ca also showed that the clip could occlude the simulated vessel without fracture. In addition, the Mg-Zn-Ca alloy clip successfully occluded the renal vein. Microstructural observations using electron backscattering diffraction confirmed that dynamic recovery occurred during the later stage of plastic deformation of the ductile Mg-Zn-Ca alloy. These results suggest that the developed Mg-Zn-Ca alloy is a suitable material for biodegradable clips. STATEMENT OF SIGNIFICANCE: Since conventional magnesium alloys have not exhibited significant ductility for applying the occlusion of vessels, the alloying of magnesium with essential elements and the control of microstructure by hot extrusion and annealing were conducted. Mechanical characterization revealed that the Mg-Zn-Ca alloy obtained by double extrusion followed by annealing at 673K for 2h possessed a fracture strain over 0.40. The biocompatibility of the alloy was confirmed by investigating its degradation behavior and the response of extraperitoneal tissue around the Mg-Zn-Ca alloy. Finite element analysis using the material data for the ductile Mg-Zn-Ca alloy also showed that the clip could occlude the simulated vessel without fracture. In addition, the Mg-Zn-Ca alloy clip successfully occluded the renal vein. Microstructural observations using electron backscattering diffraction confirmed that dynamic recovery occurred during the later stage of plastic deformation of the ductile Mg-Zn-Ca alloy.

  Jan. 2016, Acta biomaterialia, 29, 468 - 476, English, International magazine

  Scientific journal


• 大腸癌肝転移に対する肝切除時期についての検討

  吉田 俊彦, 福本 巧, 木戸 正浩, 武部 敦志, 田中 基文, 蔵満 薫, 木下 秘我, 福島 健司, 浦出 剛史, 宗 慎一, 味木 徹夫, 外山 博近, 浅利 貞毅, 後藤 直大, 松本 拓, 具 英成

  (一社)日本消化器外科学会, Oct. 2015, 日本消化器外科学会雑誌, 48(Suppl.2) (Suppl.2), 188 - 188, Japanese


• [Long-term survival in a patient receiving multidisciplinary therapy for hepatocellular carcinoma with left iliac bone metastasis].

  Shinichi So, Masahiro Kido, Takumi Fukumoto, Atsushi Takebe, Motofumi Tanaka, Hisoka Kinoshita, Kaori Kuramitsu, Daisuke Tsugawa, Kenji Fukushima, Takeshi Urade, Toshihiko Yoshida, Sadaki Asari, Taro Okazaki, Makoto Shinzeki, Ippei Matsumoto, Tetsuo Ajiki, Yonson Ku

  The patient was a 79-year-old man diagnosed with a single 9.3-cm hepatocellular carcinoma (HCC) in the medial segment of the liver, and left iliac bone metastasis. Initially, the patient was treated with a hepatic arterial infusion of low-dose FP (cisplatin/5-fluorouracil) at another hospital. Here, the patient received particle therapy for the left iliac bone metastasis at a total dose of 52.8 Gy in 4 fractions. Subsequently, he underwent medial segmentectomy of the liver to treat the primary HCC. Eleven months later, the first intrahepatic recurrence occurred, and the tumor was treated with percutaneous radiofrequency ablation (RFA). A second intrahepatic recurrence was detected 39 months later, which was also treated with percutaneous RFA. The patient remains well, with no evidence of tumor recurrence.

  Nov. 2014, Gan to kagaku ryoho. Cancer & chemotherapy, 41(12) (12), 2107 - 9, Japanese, Domestic magazine

  [Refereed]

  Scientific journal


• [A case of resection of a metastatic liver tumor that recurred after particle beam therapy].

  Toshihiko Yoshida, Atsushi Takebe, Takumi Fukumoto, Masahiro Kido, Motofumi Tanaka, Kaori Kuramitsu, Hisoka Kinoshita, Daisuke Tsugawa, Kenji Fukushima, Takeshi Urade, Shinichi So, Tetsuo Ajiki, Ippei Matsumoto, Makoto Shinzeki, Taro Okazaki, Sadaki Asari, Tadahiro Goto, Taku Matsumoto, Yonson Ku

  Recently, the indications for particle beam therapy have been expanded to include metastatic liver tumors. However, its adverse effects on the treated liver are unclear, and the possibility of local recurrence after treatment should not be ignored. A 65-year-old man with advanced rectal carcinoma underwent low anterior resection. Resectable metastatic liver tumors were detected after adjuvant chemotherapy; however, he opted to undergo particle beam therapy. Nine months after treatment, a local recurrence was detected around the treated area, and central bisegmentectomy of the liver was performed as a salvage operation. The operation was technically complicated owing to severe adhesions and inflammatory changes in the liver parenchyma around the treated area. Pathological examination revealed advanced liver fibrosis at the treated area, in contrast with normal parenchyma in the untreated area. Although the procedure requires advanced surgical techniques, salvage surgery is a feasible option for recurrent liver tumors after particle beam therapy.

  Nov. 2014, Gan to kagaku ryoho. Cancer & chemotherapy, 41(12) (12), 2071 - 3, Japanese, Domestic magazine

  [Refereed]

  Scientific journal


• 同時性腸骨転移を伴う肝細胞癌に対し集学的治療を行い長期生存を得た1例

  宗 慎一, 木戸 正浩, 福本 巧, 武部 敦志, 田中 基文, 木下 秘我, 蔵満 薫, 津川 大介, 福島 健司, 浦出 剛史, 吉田 俊彦, 浅利 貞毅, 岡崎 太郎, 新関 亮, 松本 逸平, 味木 徹夫, 具 英成

  (株)癌と化学療法社, Nov. 2014, 癌と化学療法, 41(12) (12), 2107 - 2109, Japanese


• 粒子線治療後に局所再発した転移性肝癌の1切除例

  吉田 俊彦, 武部 敦志, 福本 巧, 木戸 正浩, 田中 基文, 蔵満 薫, 木下 秘我, 津川 大介, 福島 健司, 浦出 剛史, 宗 慎一, 味木 徹夫, 松本 逸平, 新関 亮, 岡崎 太郎, 浅利 貞毅, 後藤 直大, 松本 拓, 具 英成

  (株)癌と化学療法社, Nov. 2014, 癌と化学療法, 41(12) (12), 2071 - 2073, Japanese


• [The role of preoperative percutaneous isolated hepatic perfusion and hepatectomy in multidisciplinary treatment].

  Toshihiko Yoshida, Masahiro Kido, Takumi Fukumoto, Shohei Komatsu, Masanori Takahashi, Atsushi Takebe, Motofumi Tanaka, Kaori Kuramitsu, Hisoka Kinoshita, Tetsuo Ajiki, Ippei Matsumoto, Makoto Shinzeki, Taro Okazaki, Sadaki Asari, Yonson Ku

  We report a case of multiple bilobar hepatocellular carcinoma( HCC) that was successfully treated with a multidisciplinary treatment including preoperative percutaneous isolated hepatic perfusion and hepatectomy. The patient was a 61- year-old man who was detected as having HCC mainly in segment 4 and 8 of the liver and multiple bilobar intrahepatic metastasis during follow-up evaluation for chronic hepatitis B. Curative resection was difficult because the patient had insufficient liver function and because of the location of the tumor. Hence, we performed preoperative percutaneous isolated hepatic perfusion (PIHP) to control the multiple HCC. Seven weeks after the PIHP, the tumor size had reduced, and therefore we performed an extended left hepatic lobectomy. In addition to these treatment modalities, we performed transcatheter arterial chemoembolization (TACE) 3 times owing to recurrent HCC in the right liver lobe. Considering that HCC in segment 8 can be treated with TACE, we performed partial hepatectomy. As of the last follow-up visit, the patient was alive without disease recurrence. Thus, preoperative PIHP may improve the resectability rate in patients with multiple bilobar HCC for which curative resection is difficult to perform.

  Nov. 2013, Gan to kagaku ryoho. Cancer & chemotherapy, 40(12) (12), 1822 - 4, Japanese, Domestic magazine

  [Refereed]

  Scientific journal


• 集学的治療における術前経皮的肝灌流化学療法と肝切除の位置付け

  吉田 俊彦, 木戸 正浩, 福本 巧, 小松 昇平, 高橋 応典, 武部 敦志, 田中 基文, 蔵満 薫, 木下 秘我, 味木 徹夫, 松本 逸平, 新関 亮, 岡崎 太郎, 浅利 貞毅, 具 英成

  (株)癌と化学療法社, Nov. 2013, 癌と化学療法, 40(12) (12), 1822 - 1824, Japanese

• -

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  -, Aug. 2026, Japanese, Domestic conference

  Oral presentation


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  -, Jul. 2026, Japanese, Domestic conference

  Public symposium


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  -, Jul. 2026, Japanese, Domestic conference

  Public symposium


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  -, Jul. 2026, Japanese, Domestic conference

  Public symposium


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  -, Jul. 2026, Japanese, Domestic conference

  Public symposium


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  -, Jul. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jul. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jul. 2026, Japanese, Domestic conference

  Oral presentation


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  -, Jul. 2026, Japanese, Domestic conference

  Public symposium


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  -, Jul. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jul. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jul. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jul. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jul. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jul. 2026, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jun. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jun. 2026, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Jun. 2026, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jun. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jun. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jun. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jun. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jun. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jun. 2026, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Jun. 2026, Japanese, Domestic conference

  Public symposium


• Comparison of Open and Laparoscopic Partial Resection for Caudate Lobe Tumors: Surgical Outcomes According to Tumor Location

  Takimoto D, Urade T, Kido M, Komatsu S, Fukushima K, Yoshida T, Arai K, Asari S, Nanno Y, Yanagimoto H, Fukumoto T

  -, May 2026, English, Domestic conference

  Poster presentation


• Infectious Complications After Hepatectomy in Patients With Prior Biliary-Enteric Anastomosis

  Sano H, Urade T, Takebe A, Tanaka M, Komatsu S, Fukushima K, Yoshida T, Arai K, Kido M, Matsumoto I, Fukumoto T

  -, May 2026, English, Domestic conference

  Oral presentation


• Enhancing Recruitment and Retention of Young Surgeons: The Kobe University Model of Career Support and Training Programs

  Komatsu S, Fukushima K, Mizumoto T, Yoshida T, Ishida J, Nanno Y, Urade T, Yanagimoto H, Kido M, Fukumoto T

  -, May 2026, English, Domestic conference

  Public symposium


• A Retrospective Study on the Prognosis of All Disappearing Colorectal Liver Metastases

  Shimura Y, Yoshida T, Komatsu S, Kido M, Fukushima K, Urade T, Arai K, Asari S, Yanagimoto H, Fukumoto

  -, May 2026, English, Domestic conference

  Public symposium


• Robot-assisted liver resection with da Vinci and hinotori: a single-center comparative study

  Urade T, Komatsu S, Fukushima K, So S, Yoshida T, Arai K, Iguchi K, Nanno Y, Yanagimoto H, Kido M, Fukumoto T

  -, May 2026, English, Domestic conference

  Public symposium


• Significance of Conversion Therapy Following Atezolizumab Plus Bevacizumab for Unresectable Advanced Hepatocellular Carcinoma

  Fukushima K, Komatsu S, Kido M, Urade T, Yoshida T, Arai K, Ishida J, Nanno Y, Asari S, Yanagimoto H, Fukumoto T

  -, May 2026, English, Domestic conference

  Public symposium


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  -, Apr. 2026, Japanese, Domestic conference

  Oral presentation


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  -, Apr. 2026, Japanese, Domestic conference

  Oral presentation


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  -, Apr. 2026, Japanese, Domestic conference

  Poster presentation


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  -, Apr. 2026, Japanese, Domestic conference

  Poster presentation


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  -, Apr. 2026, Japanese, Domestic conference

  Poster presentation


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  -, Apr. 2026, Japanese, Domestic conference

  Poster presentation


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  -, Apr. 2026, Japanese, Domestic conference

  Poster presentation


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  -

  -, Apr. 2026, Japanese, Domestic conference

  Poster presentation


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  -

  -, Apr. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Apr. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Apr. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Apr. 2026, Japanese, Domestic conference

  Public symposium


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  -

  -, Apr. 2026, Japanese, Domestic conference

  Public symposium


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  -

  -, Apr. 2026, Japanese, Domestic conference

  Public symposium


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  -

  -, Apr. 2026, Japanese, Domestic conference

  Public symposium


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  -, Apr. 2026, Japanese, Domestic conference

  Public symposium


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  -, Apr. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Feb. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Feb. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Feb. 2026, Japanese, Domestic conference

  Oral presentation


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  -, Feb. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Feb. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Feb. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jan. 2026, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jan. 2026, Japanese, Domestic conference

  Oral presentation


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  -, Dec. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Dec. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Dec. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Dec. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Dec. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Dec. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Dec. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Dec. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Dec. 2025, Japanese, Domestic conference

  Public symposium


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  -

  -, Dec. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Nov. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Nov. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Nov. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Nov. 2025, Japanese, Domestic conference

  Public symposium


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  -

  -, Nov. 2025, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Nov. 2025, Japanese, Domestic conference

  Public symposium


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  -

  -, Nov. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Nov. 2025, Japanese, Domestic conference

  Public symposium


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  -

  -, Nov. 2025, Japanese, Domestic conference

  Public discourse


• -

  -

  -, Oct. 2025, Japanese, Domestic conference

  Poster presentation


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  -

  -, Oct. 2025, Japanese, Domestic conference

  Poster presentation


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  -

  -, Oct. 2025, Japanese, Domestic conference

  Poster presentation


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  -

  -, Oct. 2025, Japanese, Domestic conference

  Poster presentation


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  -

  -, Oct. 2025, Japanese, Domestic conference

  Poster presentation


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  -

  -, Oct. 2025, Japanese, Domestic conference

  Poster presentation


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  -

  -, Oct. 2025, Japanese, Domestic conference

  Poster presentation


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  -

  -, Oct. 2025, Japanese, Domestic conference

  Poster presentation


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  -

  -, Oct. 2025, Japanese, Domestic conference

  Poster presentation


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  -

  -, Sep. 2025, Japanese, Domestic conference

  Others


• -

  -

  -, Sep. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Sep. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Aug. 2025, Japanese, Domestic conference

  Poster presentation


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  -

  -, Jul. 2025, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Jul. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jul. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jul. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jul. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jul. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jul. 2025, Japanese, Domestic conference

  Public symposium


• A Case of Successful Conversion Hepatectomy Following Durvalumab plus Tremelimumab Therapy under Nasogastric Feeding for Advanced Vp4 Hepatocellular Carcinoma

  Sano H, Fukushima K, Komatsu S, Kido M, Urade T, So S, Yoshida T, Tai K, Arai K, Iguchi K, Nanno Y, Asari S, Yanagimoto H, Kodama T, Fukumoto T

  The 15th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE2025), Jul. 2025, English, International conference

  Poster presentation


• Impact of tumor size on liver regeneration after hepatectomy

  Takimoto D, Komatsu S, Kido M, Gon H, Fukushima K, Urade T, Yoshida T, Tai K, Arai K, Fujinaka R, Nanno Y, Asari S, Yanagimoto H, Fukumoto T

  The 15th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE2025), Jul. 2025, English, International conference

  Poster presentation


• Prognostic and predictive value of lymphocyte-to-monocyte transition in hepatocellular carcinoma patients treated with atezolizumab plus bevacizumab

  Omori M, Komatsu S, Tada T, Ishihara N, Matsuura T, Ueshima E, Kido M, Gon H, Fukushima K, Urade T, Yoshida T, Tai K, Arai K, Yanagimoto H, Fukumoto T

  The 15th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE2025), Jul. 2025, English, International conference

  Poster presentation


• Evaluation of Nutritional Risk Assessment Methods for Hepatectomy in Hepatocellular Carcinoma

  Oji K, Urade T, Kido M, Komatsu S, Fukushima K, Yoshida T, Tai K, Arai K, Fukumoto T

  The 15th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE2025), Jul. 2025, English, International conference

  Poster presentation


• Outcomes and Indications of Curative Conversion Therapy After Immunotherapy

  Tai K, Komatsu S, Tada T, Matsuura T, Ueshima E, Omori M, Ishihara N, Kido M, Gon H, Fukushima K, Urade T, Yoshida T, Arai K, Yanagimoto H, Fukumoto T

  The 15th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE2025), Jul. 2025, English, International conference

  Poster presentation


• Impact of Initial Hepatectomy With Hilar Manipulation on Short-Term Outcomes of Repeat Hepatectomy for Recurrent Liver Cancer

  Arai K, Gon H, Komatsu S, Fukushima K, Kido M, Urade T, So S, Yoshida T, Tai K, Akita M, Yanagimoto H, Mizumoto T, Ishida J, Nanno Y, Fukumoto T

  The 15th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE2025), Jul. 2025, English, International conference

  Poster presentation


• Treatment strategy for Colorectal liver metastases based on liver resection and the benefit of preoperative chemotherapy

  Yoshida T, Komatsu S, Kido M, Gon H, Fukushima K, Urade T, So S, Tai K, Arai K, Iguchi K, Nanno Y, Ishida J, Mizumoto T, Yanagimoto H, Fukumoto T

  The 15th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE2025), Jul. 2025, English, International conference

  Poster presentation


• Laparoscopic right posterior sectionectomy using the anterior approach for huge hepatocellular carcinoma

  Urade T, Kido M, Komatsu S, Fukushima K, So S, Yoshida T, Tai K, Arai K, Iguchi K, Mizumoto T, Ishida J, Nanno Y, Asari S, Yanagimoto H, Fukumoto T

  The 15th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE2025), Jul. 2025, English, International conference

  Poster presentation


• Impact of Post-Hepatectomy Liver Failure on Long-Term Liver Function and Prognosis in Patients with Hepatocellular Carcinoma

  Fukushima K, Komatsu S, Kido M, Urade T, So S, Yoshida T, Tai K, Arai K, Iguchi K, Mizumoto T, Ishida J, Nanno Y, Asari S, Yanagimoto H, Fukumoto T

  The 15th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE2025), Jul. 2025, English, International conference

  Poster presentation


• Prognostic and predictive value of lymphocyte-to-monocyte transition in hepatocellular carcinoma patients treated with atezolizumab plus bevacizumab

  Omori M, Komatsu S, Tada T, Ishihara N, Matsuura T, Ueshima E, Kido M, Gon H, Fukushima K, Urade T, Yoshida T, Tai K, Arai K, Yanagimoto H, Fukumoto T

  The 15th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE2025), Jul. 2025, English, International conference

  Oral presentation


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  -

  -, Jul. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jul. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jul. 2025, Japanese, Domestic conference

  Oral presentation


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  -

  -, Jul. 2025, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Jul. 2025, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Jul. 2025, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Jul. 2025, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Jul. 2025, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Jul. 2025, Japanese, Domestic conference

  Invited oral presentation


• -

  -

  -, Jul. 2025, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Jun. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Jun. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Jun. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Jun. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Jun. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Jun. 2025, Japanese, Domestic conference

  Poster presentation


• Comparison of short-term outcomes between open and laparoscopic surgery for multiple liver resections

  Takimoto D, Urade T, Kido M, Komatsu S, Gon H, Fukushima K, Yoshida T, Tai K, Arai K, Yanagimoto H, Toyama H, Fukumoto T

  ILLS2025, Jun. 2025, English, International conference

  Poster presentation


• Impact of malnutrition on short- and long-term outcomes in laparoscopic liver resection for hepatocellular carcinoma

  Oji K, Urade T, Kido M, Komatsu S, Fukushima K, So S, Yoshida T, Tai K, Arai K, Fukumoto T

  ILLS2025, Jun. 2025, English, International conference

  Oral presentation


• Re-staining method with indocyanine green fluorescence imaging for laparoscopic liver resection

  Urade T, Kido M, Komatsu S, Gon H, Fukushima K, Yoshida T, Tai K, Arai K, Yanagimoto H, Toyama H, Fukumoto T

  ILLS2025, Jun. 2025, English, International conference

  Oral presentation


• Nutritional Status Assessed by GLIM and PNI as Predictors of Textbook Outcome in Liver Resection for Hepatocellular Carcinoma

  Oji K, Urade T, Kido M, Komatsu S, Gon H, Fukushima K, Yoshida T, Arai K, Yanagimoto H, Toyama H, Fukumoto T

  -, Jun. 2025, English, Domestic conference

  Poster presentation


• Effects of simultaneous portal and hepatic vein ligation for the induction of liver regeneration: Arat model of liver venous deprivation

  Fujinaka R, Urade T, Kido M, Komatsu S, Gon H, Fukushima K, Yoshida T, Asari S, Yanagimoto H, Toyama H, Fukumoto T

  -, Jun. 2025, English, Domestic conference

  Poster presentation


• Outcomes of Immune Checkpoint Inhibitors for Recurrent Hepatocellular Carcinoma After Major Hepatectomy or sectionectomy

  Tai K, Komatsu S, Kido M, Gon H, Fukushima K, Urade T, Yoshida T, Arai K, Yanagimoto H, Toyama H, Fukumoto T

  -, Jun. 2025, English, Domestic conference

  Poster presentation


• Re-staining method with indocyanine green fluorescence imaging for laparoscopic anatomical liver resection

  Urade T, Kido M, Komatsu S, Gon H, Fukushima K, Yoshida T, Tai K, Arai K, Yanagimoto H, Toyama H, Fukumoto T

  -, Jun. 2025, English, Domestic conference

  Poster presentation


• Comparison of the utility of liver reserve and fibrosis indicators in predicting posthepatectomy liver failure after right hepatectomy for hepatocellular carcinoma

  Fukushima K, Komatsu S, Kido M, Gon H, Urade T, Yoshida T, Tai K, Arai K, Yanagimoto H, Toyama H, Fukumoto T

  -, Jun. 2025, English, Domestic conference

  Poster presentation


• -

  -

  -, Jun. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, May 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, May 2025, Japanese, Domestic conference

  Public symposium


• -

  -

  -, May 2025, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Apr. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2025, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Apr. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Apr. 2025, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Mar. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Mar. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Mar. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Mar. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Feb. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jan. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jan. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jan. 2025, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jan. 2025, Japanese, Domestic conference

  Oral presentation


• Comprehensive analysis of altered lipid and amino acid metabolism in patients undergoing pancreatoduodenectomy

  Nanno Y, Toyama H, Ishida J, Mizumoto T, Akita M, Arai K, Tai K, Yoshida T, So S, Urade T, Fukushima K, Gon H, Tsugawa D, Komatsu S, Yanagimoto H, Kido M, Fukumoto T

  APA/JPS/CAP/IAP 2024, Dec. 2024, Japanese, International conference

  Oral presentation


• -

  -

  -, Dec. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Dec. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Dec. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Dec. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Dec. 2024, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Dec. 2024, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Nov. 2024, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Nov. 2024, Japanese, Domestic conference

  Public symposium


• Postoperative complications assessed by the comprehensive complication index (CCI) are associated with early recurrence after curative resection for biliary tract cancer

  Okazoe Y, Yanagimoto H, Akita M, Tsugawa D, Arai K, Yoshida T, So S, Ishida J, Nanno Y, Urade T, Fukushima K, Gon H, Komatsu S, Asari S, Toyama H, Kido M, Fukumoto T

  -, Oct. 2024, Japanese, Domestic conference

  Poster presentation


• Clinical Significance of Laparoscopic 0-mm Margin Liver Resection for Vascular in Patients with Hepatocellular Carcinoma

  Shimura Y, Urade T, Kido M, Komatsu S, Gon H, Fukushima K, Yoshida T, Arai K, Asari S, Yanagimoto H, Toyama H, Fukumoto T

  -, Oct. 2024, Japanese, Domestic conference

  Poster presentation


• -

  楠原 達樹, 小松 昇平, 徳丸 直郎, 寺嶋 千貴, 木戸 正浩, 権 英寿, 福島 健司, 浦出 剛史, 吉田 俊彦, 荒井 啓輔, 秋田 真之, 石田 潤, 南野 佳英, 津川 大介, 浅利 貞毅, 柳本 泰明, 外山 博近, 沖本 智昭, 福本 巧

  -, Oct. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Oct. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Oct. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Oct. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Oct. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Oct. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Oct. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Oct. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Oct. 2024, Japanese, Domestic conference

  Oral presentation


• -

  浦出 剛史, Kido M, Komatsu S, Gon H, Fukushima K, So S, Yoshida T, Tai K, Arai K, Oji K, Fukumoto T

  ILLS2024, Oct. 2024, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Sep. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Sep. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Sep. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Sep. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jul. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jul. 2024, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Jul. 2024, Japanese, Domestic conference

  Public symposium


• Textbook outcomes in initial liver resection for hepatocellular carcinoma: a study with malnutrition grade by the GLIM criteria.

  Oji K, Urade T, Omiya S, Kido M, Komatsu S, Gon H, Fukushima K, So S, Yoshida T, Arai K, Akita M, Ishida J, Nanno Y, Tsugawa D, Asari S, Yanagimoto H, Toyama H, Fukumoto T

  The 14th Asia-Pacific Primary Liver Cancer Expert Meeting 2024 (APPLE), Jul. 2024, Japanese, International conference

  Poster presentation


• Clinical significance of hepatectomy for Hepatocellular Carcinoma Associated with Lymph Node and/or Distant Metastases

  Fukushima K, Komatsu S, Kido M, Gon H, Urade T, So S, Yoshida T, Arai K, Yanagimoto H, Toyama H, Fukumoto T

  The 14th Asia-Pacific Primary Liver Cancer Expert Meeting 2024 (APPLE), Jul. 2024, Japanese, International conference

  Poster presentation


• -

  -

  -, Jul. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jul. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jul. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jul. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jul. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jul. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jul. 2024, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Jul. 2024, Japanese, Domestic conference

  Public symposium


• -

  Koizumi A, Urade T, Kido M, Komatsu S, Gon H, Fukushima K, Yoshida T, Arai K, Yanagimoto H, Toyama H, Fukumoto T

  -, Jun. 2024, Japanese, Domestic conference

  Public symposium


• Clinical significance of hepatectomy for hepatocellular carcinoma associated with lymph node and/ or distant metastases

  Fukushima K, Komatsu S, Kido M, Gon H, Urade T, So S, Yoshida T, Arai K, Yanagimoto H, Toyama H, Fukumoto T

  -, Jun. 2024, Japanese, Domestic conference

  Public symposium


• Treatment outcomes of hepatectomy and systemic chemotherapy based on the oncological criteria of resectability

  Komatsu S, Ishihara N, Kido M, Gon H, Fukushima K, Urade T, Yoshida T, Arai K, Yanagimoto H, Toyama H, Fukumoto T

  -, Jun. 2024, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Jun. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2024, English, International conference

  Poster presentation


• -

  -

  -, Jun. 2024, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Jun. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, May 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Apr. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2024, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Apr. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Apr. 2024, Japanese, Domestic conference

  Oral presentation


• Utility of ALBI grade for predicting prognoses in patients who underwent repeat hepatectomy

  Kusuhara T, Gon H, Kido M, Komatsu S, Fukushima K, Urade T, So S, Yoshida T, Arai K, Nanno Y, Tsugawa D, Asari S, Yanagimoto H, Toyama H, Fukumoto T

  The 33rd Annual Meeting the Asian Pacific Association for the Study of the Liver (APASL2024), Mar. 2024, English, Domestic conference

  Poster presentation


• Multidisciplinary treatment strategy for macroscopic portal vein tumor thrombus

  Komatsu S, Yano Y, Kido M, Gon H, Fukushima K, Urade T, Yoshida T, Arai K, Ishihara N, Yanagimoto H, Toyama H, Ueda Y, Fukumoto T

  The 33rd Annual Meeting the Asian Pacific Association for the Study of the Liver (APASL2024), Mar. 2024, English, Domestic conference

  Poster presentation


• A comparative study of laparoscopic liver resection for the segment 4 superior and inferior area

  Koizumi A, Urade T, Kido M, Komatsu S, Gon H, Fukushima K, So S, Yoshida T, Arai K, Nanno Y, Tsugawa D, Asari S, Yanagimoto H, Toyama H, Fukumoto T

  The 33rd Annual Meeting the Asian Pacific Association for the Study of the Liver (APASL2024), Mar. 2024, English, Domestic conference

  Oral presentation


• The Efficacy of Total Tumor Volume in Patients with Colorectal Liver Metastases

  Shimura Y, Komatsu S, Fujisawa A, Kido M, Gon H, Fukushima K, Yoshida T, Arai K, Akita M, Ishida J, Nanno Y, Tsugawa D, Fukumoto T

  The 33rd Annual Meeting the Asian Pacific Association for the Study of the Liver (APASL2024), Mar. 2024, English, Domestic conference

  Oral presentation


• -

  -

  -, Feb. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jan. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jan. 2024, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Dec. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Dec. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Dec. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Dec. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Dec. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Dec. 2023, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Dec. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Dec. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Nov. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Nov. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Nov. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Nov. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Nov. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Nov. 2023, English, Domestic conference

  Poster presentation


• -

  -

  -, Nov. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Nov. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Nov. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Nov. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Nov. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Nov. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Nov. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Sep. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Sep. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Sep. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Sep. 2023, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Sep. 2023, English, Domestic conference

  Oral presentation


• A comparative study of laparo-scopic liver resection for the segment 8 dorsal and ventral area

  Oji K, Urade T, Kido M, Komatsu S, Gon H, Fukushima K, So S, Yoshida T, Arai K, Akita M, Ishida J, Nanno Y, Tsugawa D, Goto T, Asari S, Yanagimoto H, Toyama H, Fukumoto T

  4th World Congress of International Laparoscopic liver Society（ILLS）, Sep. 2023, English, International conference

  Oral presentation


• Short-term impact of laparoscopic liver resection with 0-mm surgical margin for HCC

  Shimura Y, Urade T, Kido M, Komatsu S, Gon H, Fukushima K, So S, Yoshida T, Arai K, Tsugawa D, Yanagimoto H, Toyama H, Fukumoto T

  4th World Congress of International Laparoscopic liver Society（ILLS）, Sep. 2023, English, International conference

  Oral presentation


• Acceptability of Laparoscopic Liver Resection of Segment I: A Retrospective Study

  Fujinaka R, Urade T, Kido M, Komatsu S, Gon H, Fukushima K, So S, Yoshida T, Tsugawa D, Asari S, Yanagimoto H, Toyama H, Fukumoto T

  4th World Congress of International Laparoscopic liver Society（ILLS）, Sep. 2023, English, International conference

  Oral presentation


• Laparoscopic segmentectomy2 versus left lateral sectionecto-my for liver tumors in segment2

  Urade T, Kido M, Komatsu S, Gon H, Fukushima K, So S, Yoshida T, Arai K, Omiya S, Shimura Y, Yanagimoto H, Toyama H, Fukumoto T

  4th World Congress of International Laparoscopic liver Society（ILLS）, Sep. 2023, English, International conference

  Oral presentation


• Impact of malnutrition diagnosed by the GLIM criteria on postoperative complications after pancreaticoduodenectomy for biliary tract cancer

  Okazoe Y, Yanagimoto H, Tsugawa D, Akita M, Okawa T, Omiya S, Arai K, Yoshida T, So S, Ishida J, Urade T, Nanno Y, Fukushima K, Gon H, Komatsu S, Asari S, Toyama H, Kido M, Ajiki T, Fukumoto T

  45th ESPEN Congress, Sep. 2023, English, International conference

  Poster presentation


• Impact of malnutrition diagnosed by the GLIM criteria on outcome of elderly patients with hepatocellular carcinoma after liver resection

  Omiya S, Urade T, Komatsu S, Kido M, So S, Gon H, Fukushima K, Yoshida T, Arai K, Okazoe Y, Akita M, Ishida J, Nanno Y, Tsugawa D, Asari S, Yanagimoto H, Toyama H, Fukumoto T

  45th ESPEN Congress, Sep. 2023, English, International conference

  Poster presentation


• -

  -

  -, Sep. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jul. 2023, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Jul. 2023, Japanese, Domestic conference

  Oral presentation


• A study for infectious complication of hepatectomies in patients with preexisting bilioenteric anastomosis

  Oji K, Urade T, Kido M, Kuramitsu K, Komatsu S, Gon H, Fukushima K, So S, Yoshida T, Arai K, Akita M, Ishida J, Nanno Y, Tsugawa D, Goto T, Asari S, Yanagimoto H, Toyama H, Ajiki T, Fukumoto T

  -, Jun. 2023, English, Domestic conference

  Poster presentation


• Successful biliary drainage using hybrid EUS-BD for stricture of choledochojejunostomy

  Tsugawa D, Yanagimoto H, Akita M, Arai K, Yoshida T, Ishida J, Nanno Y, Urade T, Fukushima K, Gon H, Komatsu S, Kuramitsu K, Goto T, Asari S, Toyama H, Kido M, Ajiki T, Fukumoto T

  -, Jun. 2023, English, Domestic conference

  Poster presentation


• Intended destination for a board certified surgeon under 45

  Arai K, Komatsu S, Kido M, Kuramitsu K, Gon H, Fukushima K, Urade T, So S, Yoshida T, Akita M, Ishida J, Nanno Y, Tsugawa D, Goto T, Asari S, Yanagimoto H, Toyama H, Ajiki T, Fukumoto T

  -, Jun. 2023, English, Domestic conference

  Oral presentation


• Prognostic significance of malnutrition diagnosed by the GLIM criteria for resected extrahepatic cholangiocarcinoma: A single-center retrospective study

  Okazoe Y, Yanagimoto H, Tsugawa D, Akita M, Omiya S, Arai K, Yoshida T, So S, Ishida J, Urade T, Nanno Y, Fukushima K, Gon H, Komatsu S, Kuramitsu K, Goto T, Asari S, Toyama H, Kido M, Ajiki T, Fukumoto T

  -, Jun. 2023, English, Domestic conference

  Oral presentation


• The optimal treatment strategy of therapeutic intervention using total tumor volume in patients with colorectal liver metastases

  Shimura Y, Komatsu S, Kido M, Kuramitsu K, Gon H, Fukushima K, Urade T, So S, Yoshida T, Arai K, Tsugawa D, Goto T, Yanagimoto H, Toyama H, Fukumoto T

  -, Jun. 2023, English, Domestic conference

  Oral presentation


• Improvement in stapler pancreatic transection to reduce pancreatic fistula after laparoscopic distal pancreatectomy: twelve-year experience at a single high-volume center

  Ishida J, Toyama H, Asari S, Goto T, Nanno Y, Fukuoka H, Ami K, Akita M, Arai K, Yoshida T, So S, Urade T, Fukushima K, Gon H, Tsugawa D, Komatsu S, Kuramitsu K, Yanagimoto H, Kido M, Ajiki T, Fukumoto T

  -, Jun. 2023, English, Domestic conference

  Oral presentation


• Anterior approach for open rigththepatectomy for huge hepatocellular carcinoma

  Urade T, Kido M, Kuramitsu K, Komatsu S, Gon H, Fukushima K, So S, Yoshida T, Arai K, Omiya S, Fujinaka R, Akita M, Ishida J, Nanno Y, Tsugawa D, Goto T, Asari S, Yanagimoto H, Toyama H, Ajiki T, Fukumoto T

  -, Jun. 2023, English, Domestic conference

  Public symposium


• -

  -

  -, Jun. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Jun. 2023, Japanese, Domestic conference

  Public symposium


• -

  -

  -, Jun. 2023, Japanese, Domestic conference

  Public symposium


• The factors of predicting over-time weight increase after liver transplantation

  Shimura Y, Kuramitsu K, Kido M, Komatsu S, Gon H, Fukushima K, Urade T, So S, Yoshida T, Arai K, Tsugawa D, Goto T, Asari S, Yanagimoto H, Toyama H, Fukumoto T

  ILTS2023, May 2023, English, International conference

  Poster presentation


• Indication of liver transplantation in the treatment of newly categorized acute-on-chronic liver failure in Japan

  Kuramitsu K, Komatsu S, Kido M, Tsugawa D, Gon H, Fukushima K, Goto T, Yanagimoto H, So S, Arai K, Yoshida T, Ajiki T, Toyama H, Fukumoto T

  ILTS2023, May 2023, English, International conference

  Poster presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Poster presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Oral presentation


• -

  -

  -, Apr. 2023, Japanese, Domestic conference

  Oral presentation