Research activity information

• Accurate estimation of hip range of motion using MediaPipe and inertial sensors with machine learning models.

  Takuma Maeda, Tomoyuki Kamenaga, Atsuyuki Inui, Toshiki Kitamura, Yuichi Kuroda, Masanori Tsubosaka, Naoki Nakano, Shinya Hayashi, Tomoyuki Matsumoto, Ryosuke Kuroda

  Accurate, objective assessment of hip joint range of motion (ROM) is essential for orthopedic diagnosis and rehabilitation. Conventional tools, such as goniometers, are limited by subjectivity, inter-observer variability, and poor compatibility with telemedicine applications. This study aimed to develop and validate a markerless, video-based system for estimating hip joint ROM by integrating human pose estimation (MediaPipe) with machine-learning models using inertial sensor data as the reference standard. Twenty healthy adult males performed hip flexion/extension, abduction/adduction, and internal/external rotation movements. Skeletal coordinates extracted from the videos were converted into geometric features and used to train five regression models (linear regression, ElasticNet, support vector regression, random forest, and LightGBM). Model performance was evaluated using the coefficient of determination (R²) and mean absolute error (MAE), and Shapley additive explanations (SHAP) were used to interpret feature contributions. Among the evaluated models, tree-based methods showed high predictive accuracy, and LightGBM was used for subsequent interpretability analyses across all directions of hip ROM (R² up to 0.94; MAE 4-6°), while inertial sensor validation confirmed high measurement accuracy of the reference data. SHAP analysis revealed that distinct geometric descriptors dominated flexion/extension, abduction/adduction, and internal/external rotation, indicating direction-specific biomechanical determinants of hip motion. These findings demonstrate that markerless, video-based estimation of hip ROM is feasible with promising accuracy and highlight the potential of this approach for telemedicine, remote rehabilitation monitoring, and future integration into gait and musculoskeletal modeling workflows.

  May 2026, BMC musculoskeletal disorders, English, International magazine

  Scientific journal


• Potential Effect of Imeglimin on Mitochondrial Function in Subsynovial Connective Tissue of Idiopathic Carpal Tunnel Syndrome.

  Yutaka Ehara, Yutaka Mifune, Atsuyuki Inui, Kohei Yamaura, Issei Shinohara, Masaya Kusunose, Shuya Tanaka, Daiji Nakabayashi, Tomoyuki Matsumoto, Ryosuke Kuroda

  Patients with idiopathic carpal tunnel syndrome (CTS) exhibit impaired mitochondrial function in the subsynovial connective tissue (SSCT) of the carpal tunnel. We hypothesized that Imeglimin, a compound known to enhance mitochondrial function, may improve mitochondrial activity in SSCT from these patients. This study aimed to evaluate the effects of Imeglimin on mitochondrial function in SSCT-derived cells obtained from patients with idiopathic CTS. SSCT samples were collected from 15 patients (mean age: 67.5  ±  9.7 years) who underwent carpal tunnel release surgery between April 2022 and March 2024. The cells were cultured under control conditions (Dulbecco's Modified Eagle Medium alone) or with 100 µM Imeglimin for 24 h. Mitochondrial function was assessed using multiple assays, including cell proliferation, superoxide dismutase (SOD) activity, apoptosis rate, mitochondrial volume, membrane potential, reactive oxygen species (ROS) production, gene expression related to mitochondrial biogenesis and antioxidant capacity, mitochondrial permeability transition pore opening, and ultrastructure by transmission electron microscopy. Statistical analyses were performed using the Mann-Whitney U test, one-way ANOVA, Kruskal-Wallis test, and Fisher's protected least significant difference test, with p  <  0.05 considered significant. Compared with the control group, the Imeglimin-treated group showed significantly increased cell proliferation, SOD activity, mitochondrial membrane potential, mitochondrial volume, cristae density, and expression of genes related to mitochondrial biogenesis and antioxidant defense. Apoptosis and mitochondrial ROS production were significantly reduced (p <  0.05). These findings suggest that Imeglimin may enhance mitochondrial function in SSCT-derived cells from patients with idiopathic CTS, offering a potential therapeutic strategy for mitochondrial dysfunction in CTS.

  Oct. 2025, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, English, International magazine

  Scientific journal


• Effects of glutaminase 1 inhibitor on rotator cuff derived cells: a preliminary report in 12 patients.

  Tatsuo Kato, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Shintaro Mukohara, Tomoya Yoshikawa, Issei Shinohara, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Yuichi Hoshino, Takehiko Matsushita, Tomoyuki Matsumoto, Ryosuke Kuroda

  BACKGROUND: Glutaminase 1 (GLS1) degrades glutamate into glutamine and ammonia, and is required for the survival of senescent human cells. GLS1 inhibitors contribute to the improvement of various pathological conditions associated with aging. Rotator cuff tears (RCT) increase with age, and recently the Stump classification has been proposed to evaluate the fragility of the torn rotator cuff site, with Type 3 being the most fragile and a high risk of re-tear after rotator cuff repair surgery. We hypothesized that GLS1 expression is upregulated in the degenerated rotator cuff and that GLS1 inhibitors would improve rotator cuff degeneration. In this study, we evaluated the effects of GLS1 inhibitors on human rotator cuff-derived cells. METHODS: Twelve patients who underwent surgery for RCT were included in this study. Rotator cuff tissue was harvested during arthroscopic repair for tissue and cell evaluation. Tissue evaluation involved quantitative assessment of mRNA expression of GLS1 using real-time PCR (qPCR) and immunostaining. Rotator cuff-derived cells were isolated and cultured, divided into four groups: (1) Control group (without IL-1β and GLS1 inhibitor), (2) IL-1β(-)/GLS1 inhibitor(+), (3) IL-1β(+)/GLS1 inhibitor(-), (4) IL-1β(+)/GLS1 inhibitor(+). Cell viability was evaluated by WST assay and mRNA expression was evaluated by qPCR at 48 h after treatment. The expression of p16 and Scleraxis (SCX) was also evaluated by fluorescent immunostaining. RESULTS: Tissue evaluation showed significantly higher expression of GLS1 in Stump classification Type 3. Cell viability was significantly decreased by IL-1β loading and increased by the GLS1 inhibitor. The mRNA expression levels of GLS1, IL-6, p16 and p21 were decreased by the GLS1 inhibitor. The mRNA expression of the tendon markers, type 1 collagen, Mohawk and SCX were increased by the GLS1 inhibitor. Immunostaining revealed that the GLS1 inhibitor decreased p16 expression and increased SCX expression. CONCLUSIONS: This study showed that GLS1 was upregulated in the degenerated rotator cuff, and that the administration of a GLS1 inhibitor decreased inflammation and aging markers while increasing cell viability and tendon markers in rotator cuff-derived cells. These results indicate that GLS1 inhibitors exert anti-inflammatory effects in rotator cuff tears, prevent age-related degeneration of the rotator cuff, and promote tendon repair.

  Oct. 2025, BMC musculoskeletal disorders, 26(1) (1), 935 - 935, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Dynamic Analysis of Ultrasound Images of the Median Nerve Using Particle Image Velocimetry.

  Issei Shinohara, Takahiro Furukawa, Atsuyuki Inui, Yutaka Mifune, Kohei Yamaura, Tomoyuki Matsumoto, Ryosuke Kuroda

  Carpal tunnel syndrome (CTS) diagnosis is typically confirmed through electrophysiologic studies and ultrasound (US) imaging. Recent studies have suggested that median nerve gliding is reduced in patients with CTS. This study employed particle image velocimetry (PIV) to analyze median nerve dynamics. Ultrasound movies were captured during finger flexion and extension for 20 healthy volunteers (control group) and 20 CTS patients (CTS group). These movies were then analyzed using the PIV method. Within a 10 x 10 mm² region of interest (ROI) that included the median nerve and flexor tendon, the velocity magnitude and vector direction of movement were examined using PIV software. The maximum and mean velocity magnitudes were compared between the two groups using the Mann-Whitney U test. The maximum velocity in the ROI was significantly lower in the CTS group (9.3 ± 3.0 mm/s) than in the control group (11.5 ± 3.4 mm/s). The mean velocity was also significantly lower in the CTS group (1.7 ± 0.3 mm/s) than in the control group (2.5 ± 0.7 mm/s). Regarding motor properties, transverse motor velocity was significantly lower in CTS patients than in controls, while vertical movement showed no significant difference between the two groups. This study applied the PIV method to US images for dynamic analysis of the median nerve, revealing reduced gliding of the median nerve and flexor tendon in CTS patients, particularly in transverse movements. The application of dynamic analysis using the PIV method has potential for use in diagnosis and rehabilitation of CTS.

  Sep. 2025, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 43(9) (9), 1673 - 1678, English, International magazine

  Scientific journal


• Preoperative Increases in T2-Weighted Fat-Suppressed Magnetic Resonance Imaging Signal Intensities Associated With Advanced Tissue Degeneration and Mitochondrial Dysfunction in Rotator Cuff Tears

  Masaya Kusunose, Yutaka Mifune, Atsuyuki Inui, Kohei Yamaura, Takahiro Furukawa, Tatsuo Kato, Ryosuke Kuroda

  Elsevier BV, Jun. 2025, Arthroscopy: The Journal of Arthroscopic & Related Surgery, 41(6) (6), 1705 - 1716

  Scientific journal


• Mitochondrial Dysfunction of the Subsynovial Connective Tissue in Patients With Carpal Tunnel Syndrome.

  Shuya Tanaka, Yutaka Mifune, Atsuyuki Inui, Kohei Yamaura, Takahiro Furukawa, Tatsuo Kato, Masaya Kusunose, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda

  In idiopathic carpal tunnel syndrome (CTS), fibrosis and thickening of the subsynovial connective tissue (SSCT) increase pressure within the carpal tunnel, resulting in median nerve entrapment. Mitochondrial dysfunction in tissues reportedly leads to senescent cell accumulation and various diseases through reduced adenosine triphosphate (ATP) and excessive reactive oxygen species (ROS) production; however, no reports have linked this to CTS. Therefore, this study aimed to evaluate mitochondrial function in SSCTs of patients with CTS. This study investigated SSCTs obtained during carpal tunnel release surgery in patients with CTS (CTS group) and those obtained during tendon transfer or tendon rupture surgery in patients without CTS (control group) from April 2021 to March 2023 at our hospital. Outcome measures included superoxide dismutase (SOD) activity, gene expression levels, immunofluorescence staining, ATP production assays, and transmission electron microscopy (TEM). p values were calculated using the Mann-Whitney U test. The CTS and control groups included 10 and 5 patients (mean age, 67.8 ± 9.57 and 65.4 ± 9.75 years), respectively. The CTS group exhibited decreased SOD activity (p = 0.026), increased gene expression of mitochondrial biosynthetic factors, and decreased mitochondrial ATP production (p = 0.027). The CTS group showed increased mitochondrial ROS production (p = 0.038) on immunofluorescence and larger mitochondrial area (p = 0.030) and fewer mitochondrial cristae (p = 0.045) on TEM. Multiple mitochondrial function assays suggested mitochondrial dysfunction of SSCTs in the CTS group. STATEMENT OF CLINICAL SIGNIFICANCE: This research provided important information on the histological changes in the subsynovial connective tissue within the carpal tunnel in carpal tunnel syndrome.

  May 2025, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 43(5) (5), 1045 - 1053, English, International magazine

  Scientific journal


• Using deep learning for ultrasound images to diagnose chronic lateral ankle instability with high accuracy.

  Masamune Kamachi, Kohei Kamada, Noriyuki Kanzaki, Tetsuya Yamamoto, Yuichi Hoshino, Atsuyuki Inui, Yuta Nakanishi, Kyohei Nishida, Kanto Nagai, Takehiko Matsushita, Ryosuke Kuroda

  The purpose of this study is to calculate diagnostic accuracy of chronic lateral ankle instability (CLAI) from a confusion matrix using deep learning (DL) on ultrasound images of anterior talofibular ligament (ATFL). The study included 30 ankles with no history of ankle sprains (control group), and 30 ankles diagnosed with CLAI (injury group). A total of 2000 images were prepared for each group by capturing ultrasound videos visualizing the fibers of ATFL under the anterior drawer stress. The images of 20 feet in each group were randomly selected and used for training data and the images of remaining 10 feet in each group were used as test data. Transfer learning was performed using 3 pretraining DL models, and the accuracy, precision, recall (sensitivity), specificity, F-measure, and the area under the receiver operating characteristic curve (AUC) were calculated based on the confusion matrix. The important features were visualized using occlusion sensitivity, a method for visualizing areas that are important for model prediction. DL was able to diagnose CLAI using ultrasound imaging with very high accuracy and AUC in three different learning models. In visualization of the region of interest, AI focused on the substance of the ATFL and its attachment on the fibula for the diagnosis of CLAI.

  Apr. 2025, Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology, 40, 1 - 6, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Quantitative Evaluation of Tendon Gliding Sounds and Their Classification Using Deep Learning Models.

  Daiji Nakabayashi, Atsuyuki Inui, Yutaka Mifune, Kohei Yamaura, Tatsuo Kato, Takahiro Furukawa, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda

  This study aims to develop and evaluate a deep learning (DL) model for classifying tendon gliding sounds recorded using digital stethoscopes (Nexteto, ShareMedical, Japan, Nagoya). Specifically, we investigate whether differences in tendon excursion and biomechanics produce distinct acoustic signatures that can be identified through spectrogram analysis and machine learning (ML). Tendon disorders often present characteristic tactile and acoustic features, such as clicking or resistance during movement. In recent years, artificial intelligence (AI) and ML have achieved significant success in medical diagnostics, particularly through pattern recognition in medical imaging. Leveraging these advancements, we recorded tendon gliding sounds from the thumb and index finger in healthy volunteers and transformed these recordings into spectrograms for analysis. Although the sample size was small, we performed classification based on the frequency characteristics of the spectrograms using DL models, achieving high classification accuracy. These findings indicate that AI-based models can accurately distinguish between different tendon sounds and strongly suggest their potential as a non-invasive diagnostic tool for musculoskeletal disorders. This approach could offer a non-invasive diagnostic tool for detecting tendon disorders such as tenosynovitis or carpal tunnel syndrome, potentially aiding early diagnosis and treatment planning.

  Apr. 2025, Cureus, 17(4) (4), e81790, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Evaluating ChatGPT's Performance in Classifying Pertrochanteric Fractures Based on Arbeitsgemeinschaft für Osteosynthesefragen/Orthopedic Trauma Association (AO/OTA) Standards.

  Mitsuaki Noda, Shunsuke Takahara, Shinya Hayashi, Atsuyuki Inui, Keisuke Oe, Takehiko Matsushita

  Introduction Generative Pre-Training Transformer (ChatGPT) has become widely recognized for its capability to generate text, synthesize complex information, and perform a variety of tasks without requiring human specialists for data collection. The latest iteration, ChatGPT-4, is a large multimodal model capable of integrating both text and image inputs, rendering it particularly promising for medical applications. However, its efficacy in analyzing radiographic images remains largely unexplored. Aim This study aims to (i) address the lack of data on the accuracy of ChatGPT in radiographic fracture classification into stable or unstable under the revised Arbeitsgemeinschaft für Osteosynthesefragen/Orthopedic Trauma Association (AO/OTA) classification system, and this procedure is also performed by surgeons, and (ii) compare the agreement between surgeons or ChatGPT-based performance. The study hypothesizes that the use of ChatGPT would achieve moderate agreement with orthopedic surgeons. Materials and methods Patients diagnosed with pertrochanteric fractures were retrospectively collected. Patients with both preoperative two-directional plain radiographs and CT scans (3D-CT) images were conditioned for enrollment into the study. Two orthopedic surgeons (observer 1 and observer 2, respectively) and one resident (observer 3) were once assigned to dichotomized groups into A1 (stable) or A2 (unstable) based on AO/OTA classification using two-directional plain radiographs. Prior to the ChatGPT study, all the anteroposterior images trimmed at the fractured side, attached with figure names including gender, and age, were inputted into OpenAI ChatGPT-4. Radiological evaluation prompts were designed to initiate ChatGPT's classification analysis of the uploaded radiographic images. A single observer (MN) decided the classification patterns by examining 3D CT scan images as well as plain radiographs. This judgment of A1 (stable) and A2 (unstable) was set as a benchmark to mark the results of observers and ChatGPT based on plain radiographs. Results The cohort consisted of 29 males and 90 females, with a mean age of 87 years after the data exclusion. The fractures were classified into A1 (stable) and A2 (unstable) groups based on CT imaging. The A1 group included 50 patients (13 males, 37 females; mean age: 86.2 ± 7.8 years), while the A2 group included 69 patients (16 males, 53 females; mean age: 87.0 ± 7.9 years). Kappa values for fracture classification between plain radiographs evaluated by the three observers and ChatGPT, compared to the CT-based gold standard, showed fair to moderate agreement: Observer 1: 0.494 (95% CI: 0.337-0.650), Observer 2: 0.390 (95% CI: 0.227-0.553), Observer 3: 0.360 (95% CI: 0.198-0.521), and ChatGPT: 0.420 (95% CI: 0.255-0.585). ChatGPT demonstrated accuracy, sensitivity, specificity, and positive and negative predictable values comparable to the human observers, suggesting moderate reliability. Conclusion This study demonstrates that ChatGPT can classify pertrochanteric fractures into A1 (stable) and A2 (unstable) under the Revised AO/OTA Classification System. Its moderate agreement with CT-based assessments (κ = 0.420) is comparable to the performance of orthopedic surgeons. Moreover, ChatGPT is straightforward to integrate into clinical workflows, requiring minimal data collection for training.

  Jan. 2025, Cureus, 17(1) (1), e78068, English, International magazine

  Scientific journal


• Quantification of Empty Lacunae in Tissue Sections of Osteonecrosis of the Femoral Head Using YOLOv8 Artificial Intelligence Model.

  Issei Shinohara, Atsuyuki Inui, Masatoshi Murayama, Yosuke Susuki, Qi Gao, Simon Kwoon-Ho Chow, Yutaka Mifune, Tomoyuki Matsumoto, Ryosuke Kuroda, Stuart B Goodman

  Histomorphometry is an important technique in the evaluation of non-traumatic osteonecrosis of the femoral head (ONFH). Quantification of empty lacunae and pyknotic cells on histological images is the most reliable measure of ONFH pathology, yet it is time and manpower consuming. This study focused on the application of artificial intelligence (AI) technology to tissue image evaluation. The aim of this study is to establish an automated cell counting platform using YOLOv8 as an object detection model on ONFH tissue images and to evaluate and validate its accuracy. From 30 ONFH model rabbits, 270 tissue images were prepared; based on evaluations by three researchers, ground truth labels were created to classify each cell in the image into two classes (osteocytes and empty lacunae) or three classes (osteocytes, pyknotic cells, and empty lacunae). Two and three classes were then annotated on each image. Transfer learning based on annotated data (80% for training and 20% for validation) was performed using YOLOv8n and YOLOv8x with different parameters. To evaluate the detection accuracy of the training model, the mean average precision (mAP (50)) and precision-recall curve were identified. In addition, the reliability of cell counting by YOLOv8 relative to manual cell counting was evaluated by linear regression analysis using five histological images unused in previous experiments. The mAP (50) for the detection of empty lacunae was 0.868 for the YOLOv8n and 0.883 for the YOLOv8x. The mAP (50) for the three classes was 0.735 for the YOLOv8n model and 0.750 for the YOLOv8x model. The quantification of empty lacunae by automated cell counting obtained in the learning was highly correlated with the manual counting data. The development of an AI-applied automated cell counting platform will significantly reduce the time and effort of manual cell counting in histological analysis.

  Dec. 2024, Journal of biomedical materials research. Part B, Applied biomaterials, 112(12) (12), e35512, English, International magazine

  Scientific journal


• Leveraging AI models for lesion detection in osteonecrosis of the femoral head and T1‐weighted MRI generation from radiographs

  Issei Shinohara, Atsuyuki Inui, Katherine Hwang, Masatoshi Murayama, Yosuke Susuki, Tomohiro Uno, Qi Gao, Mayu Morita, Simon Kwoon‐Ho Chow, Masanori Tsubosaka, Yutaka Mifune, Tomoyuki Matsumoto, Ryosuke Kuroda, Stuart B. Goodman

  Abstract This study emphasizes the importance of early detection of osteonecrosis of the femoral head (ONFH) in young patients on long‐term glucocorticoid therapy, including those with acute lymphoblastic leukemia, lupus, and other diagnoses. While X‐ray and magnetic resonance imaging (MRI) are standard imaging methods for staging ONFH, MRI can be costly and time‐consuming. The research focuses on utilizing artificial intelligence (AI) to enhance the evaluation of radiographic images for ONFH detection. The study involved analyzing X‐ray and MRI from 102 control hips and 104 ONFH‐affected hips at Association Research Circulation Osseous (ARCO) Stage II and IIIa. We employed transfer learning with the YOLOv8 model for object detection, using 80% of the data for training and 20% for validation, then assessed detection accuracy through mean average precision (mAP) and a precision‐recall curve. Additionally, AI generated synthetic MRI (sMRI) from X‐ray images using a Generative Adversarial Network (GAN) and evaluated their similarity to original MRI. Results showed that the mAP for ONFH detection was 0.923 for the YOLOv8n model and 0.951 for YOLOv8x. The GAN‐generated sMRI exhibited lower image quality compared with originals but maintained potential for lesion assessment. Intrarater reliability among evaluators was high. The findings indicate that AI techniques, particularly YOLOv8 for object detection and GAN for image generation, can effectively assist in ONFH screening, despite some limitations in the generated MRI quality.

  Wiley, Nov. 2024, Journal of Orthopaedic Research

  Scientific journal


• Assessing the Elasticity of the Flexor Pronator Muscles After Throwing Using Ultrasound Shear Wave Elastography.

  Shintaro Mukohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Issei Shinohara, Yuichi Hoshino, Takehiko Matsushita, Tomoyuki Matsumoto, Ryosuke Kuroda

  BACKGROUND: The medial ulnar collateral ligament (UCL) of the elbow joint is the primary restraint to valgus stress during the throwing motion. The flexor pronator muscles (FPMs) also stabilize the elbow joint against valgus forces; however, assessment of FPM stiffness in baseball players has been limited. PURPOSE: To use ultrasound shear wave elastography (USWE) to evaluate the change in tissue elasticity of the FPMs due to pitching. STUDY DESIGNS: Descriptive laboratory study. METHODS: Included were 14 healthy male amateur baseball players (mean age, 28.0 ± 2.6 years) who had played intermediate-level high school or college baseball. The tissue elasticity of the flexor digitorum superficialis (FDS) in the superficial layer of the FPMs and the flexor digitorum profundus (FDP) in the deep layer of the FPMs were measured using USWE before, immediately after, and 24 hours after a throwing session of 100 pitches. The intra- and interrater reliability of the measurements were evaluated using the Pearson correlation coefficient and intraclass correlation coefficient (ICC). The elasticity of each muscle was analyzed using repeated-measures analysis of variance followed by post hoc analysis. RESULTS: Reliability of the USWE measurements was good to excellent (intrarater ICCs, 0.78-0.94; interrater ICCs, 0.85-0.96). The mean tissue elasticity values before, immediately after, and 24 hours after pitching were 22.3 ± 4.4, 41.0 ± 13.8, and 38.3 ± 11.2 kPa, respectively, for the FDS and 27.1 ± 5.8, 48.0 ± 22.3, and 29.6 ± 11.5 kPa, respectively, for the FDP. For both the FDS and FDP, elasticity was significantly higher immediately after pitching than before pitching (P < .001 and P = .0027, respectively). While the elasticity of the FDS at 24 hours after pitching remained significantly higher compared with before pitching (P = .0011), the elasticity of the FDP at 24 hours decreased to the same level as before pitching (P = .91). CONCLUSION: Results using USWE indicated that the elasticity of the FDS did not decrease 24 hours after pitching and remained significantly higher than before pitching, suggesting that it may not be fully functioning as a dynamic stabilizer during this period. CLINICAL RELEVANCE: Pitching in such a condition may result in greater stress on the UCL and increase the risk of UCL injury.

  Nov. 2024, Orthopaedic journal of sports medicine, 12(11) (11), 23259671241298001 - 23259671241298001, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Posture Estimation Model Combined With Machine Learning Estimates the Radial Abduction Angle of the Thumb With High Accuracy.

  Issei Shinohara, Atsuyuki Inui, Yutaka Mifune, Kohei Yamaura, Ryosuke Kuroda

  The thumb function is complex, and accurate evaluation through images or videos is difficult. Pose estimation, a technology that uses artificial intelligence (AI) to estimate skeletal detection of the body, is gaining popularity. In this study, we combined the pose estimation library MediaPipe-Hands and five machine learning (ML) models to predict the radial abduction angle of the thumb. Radial abduction movements of 20 hands from 10 healthy volunteers were captured on video and processed into 5,000 images. Angle measurements by goniometer were used as true values to evaluate the angle reliability of the MediaPipe-Hands and the angle reliability of the MediaPipe-Hands combined with ML. The correlation coefficient (CC) between the angle measured by goniometry and the angle calculated by MediaPipe-Hands was 0.84. In contrast, applying ML to MediaPipe-Hands resulted in models with improved accuracy, and all models showed high CCs (0.94-099) with angle measurements taken by goniometry. The ML model also predicted the abduction angles when the camera was taken from three different angles. In visualizing the features that the AI deemed important, the ML model predicted the abduction angle by focusing on the tip distance between the thumb and index finger along with the angle of the metacarpophalangeal joint between the thumb and middle finger. These results enable angle estimation even without frontal imaging with a camera, and expansion of this system may lead to real-time functional assessment in telemedicine and rehabilitation without the need for physical contact.

  Oct. 2024, Cureus, 16(10) (10), e71034, English, International magazine

  Scientific journal


• Does the Instability of Pertrochanteric Fractures in the Elderly Correlate With Weakened Gluteal Muscles?

  Mitsuaki Noda, Shunsuke Takahara, Shinya Hayashi, Atsuyuki Inui, Keisuke Oe, Shin Osawa, Takehiko Matsushita

  Introduction Suboptimal outcomes were observed in cases of unstable pertrochanteric fractures, even when bone healing occurs without complications. This raises the question of whether factors beyond bone health integrity, such as the frailty of muscles, contribute to these less favorable results. Muscles, particularly the gluteal muscles, not only influence functional ability but also serve as a cushion that provides physical protection against external forces during falls. When gluteal muscles are thin or weak, their ability to absorb the impact from a fall diminishes, potentially leading to unstable fractures. In this study, we compared gluteal muscle-related indices, including cross-sectional area (CSA) and muscle density, between stable and unstable pertrochanteric fractures. The aim of this study was to employ a retrospective approach to investigate the causes of unstable fractures, with a focus on potential muscular pathology. It was hypothesized that reduced CSA and lower density of the gluteal muscles would be associated with unstable fractures. Material and methods Geriatric patients aged 70 years or older with pertrochanteric fractures requiring surgical intervention were retrospectively identified from databases. These fractures classified as stable (A1) or unstable (A2) based on the Revised Arbeitsgemeinschaft für Osteosynthesefragen (AO)/Orthopaedic Trauma Association (OTA) Classification were compared based on demographic variables (age, height, body mass index (BMI), and fracture laterality) as well as muscle-related indices. A multivariate logistic regression model was employed to identify predictors of unstable fractures. Independent variables included age at the time of surgery, height, BMI, and muscular metrics CSA and density of the gluteus maximus and gluteus medius. Results Out of 220 patients identified from the database, 111 patients with an average age of 88 years (ranging from 71 to 103 years) were included. This cohort consisted of 40 patients with stable fractures (A1) and 71 patients with unstable fractures (A2). Among the demographical data, only fracture laterality demonstrated a significant difference between the groups (p < 0.05). Regarding gluteal muscle data, the CSA/BMI of both the gluteus maximus and medius, as well as the density of the gluteus medius, did not show significant differences between the two groups. The only exception was the density of the gluteus maximus, which was significantly lower in the unstable group (p < 0.01). A binary logistic regression analysis was conducted to identify risk factors for unstable fractures. The analysis found that the density of the gluteus maximus was a statistically significant predictor, with an odds ratio of 0.959 (95% CI, 0.923 to 0.997; p = 0.03). To determine an optimal cut-off value, receiver operating characteristic (ROC) analysis was performed for the density of the gluteus maximus. The Youden index identified a cut-off value of 20.8 HU for the gluteus maximus density as the optimal threshold (area under the curve (AUC): 0.625; 95% CI: 0.520-0.730). Conclusion This retrospective study investigated whether unstable pertrochanteric fractures in elderly female patients were linked to weakened gluteal muscles, compared to stable fractures, and suggested this muscle weakness may contribute to poor functional outcomes. Our binary regression analysis indicated that decreased muscle density in the gluteus maximus increases the risk of unstable fractures.

  Oct. 2024, Cureus, 16(10) (10), e72159, English, International magazine

  Scientific journal


• Postoperative Gait Performance Following Pertrochanteric Fractures Is Influenced by the Preoperative Condition of the Gluteal Muscles.

  Mitsuaki Noda, Shunsuke Takahara, Atsuyuki Inui, Keisuke Oe, Shin Osawa, Takehiko Matsushita

  Introduction Amid an increasing number of patients with pertrochanteric fractures, early prediction of postoperative gait potential could reduce unnecessary rehabilitation and hospitalization. The relationship between preoperative gluteal muscle condition and postoperative gait outcomes remains unclear. The gluteal muscles are crucial for mobility, and their cross-sectional area (CSA) and fatty infiltration are indicators of physical function. Preoperative computed tomography (CT) provides quantitative data on muscle CSA and density, measured in Hounsfield Units (HU). This study aimed to identify which preoperative muscle index, CSA, BMI-adjusted CSA, or muscle density, best predicts postoperative gait ability. We hypothesized that a higher adjusted CSA and muscle density in the gluteus muscles would be associated with superior gait performance. Materials and methods Preoperative assessments included radiographs and CT scans. Patients under 75, with less than four weeks of follow-up, prior contralateral hip surgery, prefracture immobility, male patients, high-energy trauma, or conditions impairing physical performance were excluded. Gait performance was evaluated four weeks postoperatively, classifying patients into two groups: the 'parallel bar group,' requiring parallel bars, and the 'walker group,' walking independently. Patients underwent CM nailing. Preoperative CT scans measured the CSA and muscle density of the gluteus maximus and medius. Measurements were taken from the non-injured side to avoid interference from the fracture. Muscle borders were manually traced, and the CSA and muscle density in HU were calculated. Results Out of 81 patients, 49 met the inclusion criteria (mean age: 87). The patients were divided into the 'parallel bar group' (n=19) and the 'walker group' (n=30) based on postoperative gait performance. No significant differences in age, weight, height, or fracture laterality were observed between groups. The mean (and standard deviation (SD)) of CSA for the gluteus maximus in the 'parallel bar group'/in the 'walker group' was 2211.8 ± 469.8 mm²/2440.0 ± 586.2 mm², respectively (p=0.15), and for the gluteus medius, it was 1751.7 ± 415.2mm²/1869.1 ± 448.3mm², respectively (p=0.36). The mean (and SD) muscle density for the gluteus maximus in the 'parallel bar group'/in the 'walker group' was 13.6 ± 12.7 HU / 20.6 ± 13.0 HU (p=0.07), and for the gluteus medius, it was 25.2 ± 8.4 HU/31.8 ± 10.1 HU, respectively (p=0.02). The ROC curve identified a 30.9 HU cut-off for gluteus medius density, with sensitivity and specificity of 60.7% and 78.9%. The mean (and SD) of BMI-adjusted CSA for the gluteus maximus in the 'parallel bar group'/ in the 'walker group' was 116.4 ± 26.8 m²/106 kg/124.3 ± 29.2 m²/106 kg, respectively (p=0.35), and for the gluteus medius, it was 93.3 ± 27.2 m²/106 kg/95.4 ± 21.3m²/106kg, respectively (p=0.78). Conclusion This study analyzed preoperative CT images of women aged 75 and older with pertrochanteric fractures, comparing gluteal muscle CSA and density with postoperative walking ability. The gluteus medius density was significantly higher in the superior gait group, with a cut-off value of 30.9 HU. However, no significant differences were found in the gluteus maximus density, CSA, or BMI-adjusted CSA. These findings partially support the hypothesis, emphasizing the importance of muscle evaluation in predicting postoperative gait performance.

  Aug. 2024, Cureus, 16(8) (8), e68176, English, International magazine

  Scientific journal


• Estimation of Shoulder Joint Rotation Angle Using Tablet Device and Pose Estimation Artificial Intelligence Model.

  Shunsaku Takigami, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Kohei Yamaura, Tatsuo Kato, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Yutaka Ehara, Ryosuke Kuroda

  Traditionally, angle measurements have been performed using a goniometer, but the complex motion of shoulder movement has made these measurements intricate. The angle of rotation of the shoulder is particularly difficult to measure from an upright position because of the complicated base and moving axes. In this study, we attempted to estimate the shoulder joint internal/external rotation angle using the combination of pose estimation artificial intelligence (AI) and a machine learning model. Videos of the right shoulder of 10 healthy volunteers (10 males, mean age 37.7 years, mean height 168.3 cm, mean weight 72.7 kg, mean BMI 25.6) were recorded and processed into 10,608 images. Parameters were created using the coordinates measured from the posture estimation AI, and these were used to train the machine learning model. The measured values from the smartphone's angle device were used as the true values to create a machine learning model. When measuring the parameters at each angle, we compared the performance of the machine learning model using both linear regression and Light GBM. When the pose estimation AI was trained using linear regression, a correlation coefficient of 0.971 was achieved, with a mean absolute error (MAE) of 5.778. When trained with Light GBM, the correlation coefficient was 0.999 and the MAE was 0.945. This method enables the estimation of internal and external rotation angles from a direct-facing position. This approach is considered to be valuable for analyzing motor movements during sports and rehabilitation.

  May 2024, Sensors (Basel, Switzerland), 24(9) (9), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Estimating the Thumb Rotation Angle by Using a Tablet Device With a Posture Estimation Artificial Intelligence Model.

  Yutaka Ehara, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Kohei Yamaura, Tatsuo Kato, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Shunsaku Takigami, Ryosuke Kuroda

  MediaPipe Hand (MediaPipe) is an artificial intelligence (AI)-based pose estimation library. In this study, MediaPipe was combined with four machine learning (ML) models to estimate the rotation angle of the thumb. Videos of the right hands of 15 healthy volunteers were recorded and processed into 9000 images. The rotation angle of the thumb (defined as angle θ from the palmar plane, which is defined as 0°) was measured using an angle measuring device, expressed in a radian system. Angle θ was then estimated by the ML model by using parameters calculated from the hand coordinates detected by MediaPipe. The linear regression model showed a root mean square error (RMSE) of 12.23, a mean absolute error (MAE) of 9.9, and a correlation coefficient of 0.91. The ElasticNet model showed an RMSE of 12.23, an MAE of 9.95, and a correlation coefficient of 0.91; the support vector machine (SVM) model showed an RMSE of 4.7, an MAE of 2.5, and a correlation coefficient of 0.99. The LightGBM model achieved high values: an RMSE of 4.58, an MAE of 2.62, and a correlation coefficient of 0.99. Based on these findings, we concluded that the thumb rotation angle can be estimated with high accuracy by combining MediaPipe and ML.

  May 2024, Cureus, 16(5) (5), e59657, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Re-tear after arthroscopic rotator cuff tear surgery: risk analysis using machine learning.

  Issei Shinohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Tomoya Yoshikawa, Tatsuo Kato, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Yuichi Hoshino, Takehiko Matsushita, Makoto Mitani, Ryosuke Kuroda

  BACKGROUND: Postoperative rotator cuff retear after arthroscopic rotator cuff repair (ARCR) is still a major problem. Various risk factors such as age, gender, and tear size have been reported. Recently, magnetic resonance imaging-based stump classification was reported as an index of rotator cuff fragility. Although stump type 3 is reported to have a high retear rate, there are few reports on the risk of postoperative retear based on this classification. Machine learning (ML), an artificial intelligence technique, allows for more flexible predictive models than conventional statistical methods and has been applied to predict clinical outcomes. In this study, we used ML to predict postoperative retear risk after ARCR. METHODS: The retrospective case-control study included 353 patients who underwent surgical treatment for complete rotator cuff tear using the suture-bridge technique. Patients who initially presented with retears and traumatic tears were excluded. In study participants, after the initial tear repair, rotator cuff retears were diagnosed by magnetic resonance imaging; Sugaya classification types IV and V were defined as re-tears. Age, gender, stump classification, tear size, Goutallier classification, presence of diabetes, and hyperlipidemia were used for ML parameters to predict the risk of retear. Using Python's Scikit-learn as an ML library, five different AI models (logistic regression, random forest, AdaBoost, CatBoost, LightGBM) were trained on the existing data, and the prediction models were applied to the test dataset. The performance of these ML models was measured by the area under the receiver operating characteristic curve. Additionally, key features affecting retear were evaluated. RESULTS: The area under the receiver operating characteristic curve for logistic regression was 0.78, random forest 0.82, AdaBoost 0.78, CatBoost 0.83, and LightGBM 0.87, respectively for each model. LightGBM showed the highest score. The important factors for model prediction were age, stump classification, and tear size. CONCLUSIONS: The ML classifier model predicted retears after ARCR with high accuracy, and the AI model showed that the most important characteristics affecting retears were age and imaging findings, including stump classification. This model may be able to predict postoperative rotator cuff retears based on clinical features.

  Apr. 2024, Journal of shoulder and elbow surgery, 33(4) (4), 815 - 822, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Treatment of Osteoporosis in Men on Androgen Deprivation Therapy in Japan.

  Hanako Nishimoto, Atsuyuki Inui, Yutaka Mifune, Kohei Yamaura, Yukari Bando, Yasuyoshi Okamura, Takuto Hara, Tomoaki Terakawa, Ryosuke Kuroda

  Background and Objectives: Androgen deprivation therapy (ADT) for prostate cancer has greatly improved treatment outcomes. As patient survival rates have increased, reports of decreased bone density and increased bone fractures as side effects of ADT have emerged. The prevalence of osteoporosis in Japanese men was 4.6%. The purpose of this study was to evaluate the effect of osteoporosis treatment in prostate cancer patients who underwent ADT in Japan. Materials and Methods: The subjects were 33 male patients who had undergone ADT for prostate cancer, who were noted to have decreased bone density. Mean age was 76.2 ± 7.7 years (64-87). Medications included vitamin D in one case, bisphosphonates (BP) in 27 cases, and denosumab in five cases. The evaluation method examined the rate of change in bone mineral density (BMD) before osteoporosis treatment and 1 year after. For comparison, a group without osteoporosis treatment intervention (n = 33) was selected, and matched for prostate cancer treatment and age. The rate of change in trabecular bone score (TBS) was also calculated. Results: The percentage changes in BMD before and 1 year after treatment were as follows: lumbar spine, 7.1 ± 5.8% in the treatment group versus -3.9 ± 4.1% in the no treatment group; femoral neck, 5.5 ± 6.2% in the treatment group versus -0.9 ± 3.9% in the no treatment group; total femur, 6.6 ± 6.4% in the treatment group versus the no treatment group which was -1.7 ± 3.2%. In all cases, there was a clear significant difference (p < 0.01). The percent change in TBS was further calculated in the same manner. There was no significant difference between the two groups: +1.7 ± 3.8% in the treated group versus +0.3 ± 4.1% in the untreated group. Conclusions: Osteoporosis treatment in Japanese patients with prostate cancer on ADT therapy was found to significantly increase BMD compared to the untreated group. BP and denosumab were found to be very effective in increasing BMD.

  Mar. 2024, Medicina (Kaunas, Lithuania), 60(4) (4), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Lateral Collateral Ligament Reconstruction Using the Triceps Brachii Fascia for Posterolateral Rotatory Instability in Cubitus Varus: A Report of Two Cases.

  Tatsuya Ito, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Ryosuke Kuroda

  A combination of osteotomy and ligament reconstruction is recommended for posterolateral rotatory instability (PLRI) with large cubitus varus deformities. There is a lack of reports regarding ligament donor selection for ligament reconstruction of PLRI with cubitus varus. Two cases of PLRI with cubitus varus have been described. In case one, a 40-year-old woman presented with left elbow pain. She had a cubitus varus deformity, resulting from a childhood elbow fracture. Radiographs showed an 18-degree cubitus varus deformity. A lateral closing wedge osteotomy and double plate osteosynthesis were performed. The lateral collateral ligament (LCL) was reconstructed with autologous triceps fascia. Postoperative radiographs confirmed correction with 10 degrees of the carrying angle (CA). Bone union at the osteotomy site occurred six months later with excellent results. In case two, a 45-year-old man presented an arm with persistent right elbow instability with cubitus varus deformity. This was due to a childhood supracondylar fracture of the right humerus. Radiographs showed a cubitus varus deformity of 25 degrees on the right. The surgical procedure included a lateral wedge osteotomy, double plate fixation, and LCL reconstruction with autologous triceps fascia. Postoperative radiographs confirmed a corrected CA of 5 degrees. Bone union was achieved at the six-month follow-up with satisfactory results. The use of triceps fascia for LCL reconstruction for PLRI due to cubitus varus would provide a minimally invasive and reasonable treatment option.

  Feb. 2024, Cureus, 16(2) (2), e54530, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Posterior Protrusion Measures (PPM) for Three-Dimensional (3D) CT Classification of Pertrochanteric Fractures.

  Mitsuaki Noda, Shunsuke Takahara, Atsuyuki Inui, Keisuke Oe, Shin Osawa, Takehiko Matsushita

  Introduction We introduced a novel numerical index known as posterior protrusion measures (PPM), derived from lateral plain radiograph images, which effectively serves to distinguish stable from unstable pertrochanteric fractures. The present study aims to scrutinize PPM values among two classified fracture patterns, stable and unstable, within the three-dimensional (3D) CT classification system, establishing a numeric threshold for PPM to differentiate between these groups; explore the potential relationship between the PPM index and unclassified categories; investigate how groups divided by the PPM threshold value can predict fracture stability based on 3D CT. Materials and methods In this study, three observers were tasked with measuring PPM on a single occasion. The chi-square test assessed the association between each demographic parameter on a categorical scale and stable/unstable groups. Continuous variables were also subject to examination. Receiver operating characteristic (ROC) analysis was employed to determine optimal cut-off points of PPM for predicting the presence of stable versus unstable groups. Additionally, the chi-square test examined the linear relation between separated groups based on the defined threshold PPM value and the stable/unstable groups. Results A total of 106 pertrochanteric fractures were identified using CT scan images and plain radiographs in the 3D CT classification system, revealing the stable group of 35 patients and the unstable group of 71 patients. The PPM values for stable/unstable fractures were, on average (± standard deviation), 0.34±0.25/0.50±0.29 for observer 1, 0.31±0.23/0.57±0.31 for observer 2, and 0.41±0.29/0.57±0.26 for observer 3, respectively (p<0.01). We established 0.3 as the cut-off value for PPM. The average PPM value among three observers represented each patient to assess fracture stability. The group with PPM <0.3 included 27 patients (16 stable and 11 unstable), and the group with PPM ≥0.3 group comprised 79 patients (19 stable and 60 unstable; p<0.005). Conclusion The present study revealed a significant difference in PPM values among stable and unstable 3D CT classification groups. Additionally, a threshold PPM value of 0.3 suggests a pivotal point for differentiating fracture stability. This innovative methodology makes a substantial contribution to clinical endeavors, potentially circumventing the necessity for 3D CT scanning.

  Dec. 2023, Cureus, 15(12) (12), e51363, English, International magazine

  Scientific journal


• Intra-articular site-specific distribution of advanced glycation end products in the shoulder of patients with diabetes mellitus having rotator cuff tears.

  Tatsuo Kato, Issei Shinohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Tomoya Yoshikawa, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Advanced glycation end products (AGEs) are compounds formed due to aging and diabetes mellitus (DM). They activate NADPH oxidase (NOX) by binding to their receptors, thereby increasing the production of reactive oxygen species (ROS), which cause oxidative stress. In this study, we investigated the effects of AGEs on the tissues of the shoulder joint (such as rotator cuff synovium, and capsule) in patients with DM having rotator cuff tears. METHODS: This study included eight patients with DM who underwent surgical treatment for rotator cuff tears with contracture. The rotator cuff, synovium, and joint capsule were harvested at the time of surgery and evaluated by hematoxylin-eosin staining. Furthermore, immunostaining was used for evaluating AGEs and receptor for AGEs (RAGE), cell activity, ROS, and apoptosis. Quantitative real-time polymerase chain reaction (qPCR) was employed for the cellular evaluation of NOX, interleukins, RAGE, and collagen. RESULTS: The AGEs and RAGE staining as well as the ratio of ROS and apoptosis were in the following order: rotator cuff > joint capsule > synovium. In contrast, the cellular activity was significantly higher in the synovium than in the other regions. The type I collagen expression (as shown by qPCR) as well as the RAGE and NOX expressions were as follows: rotator cuff > joint capsule > synovium. Conversely, the expression of inflammatory cytokines (i.e., IL-6 and IL-1β) was higher in the synovium than in the other regions. CONCLUSIONS: Our study is among the first to evaluate the effects of AGEs on each tissue of the shoulder joint in patients with DM having rotator cuff tears and contractures. The accumulation of AGEs in each tissue of the shoulder joint could reveal the locations affected by DM, which can lead to a better understanding of the pathophysiology of DM-related shoulder diseases.

  Dec. 2023, Molecular biology reports, 50(12) (12), 10339 - 10349, English, International magazine

  Scientific journal


• Inter-observer Agreement and Reproducibility of Pertrochanteric Fracture Classification Using Plain Radiograph Versus Computed Tomogram Images: A Study of 523 Patients.

  Mitsuaki Noda, Shunsuke Takahara, Atsuyuki Inui, Shin Osawa, Takehiko Matsushita

  Background A precise preoperative imaging classification system for pertrochanteric fractures is imperative due to the reported unreliability of the current classification system, which relies solely on plain radiographs. This study aims to achieve two primary objectives: (i) elucidate the reproducibility of pertrochanteric fracture evaluation based on the Revised Arbeitsgemeinschaft für Osteosynthesefragen/Orthopedic Trauma Association (AO/OTA) Classification, comparing plain radiographs and computed tomography (CT) scan images, and (ii) investigate the consistency of fracture classification between both imaging modalities. Methods A total of 523 patients (112 males and 411 females, mean age 85 years) who had both preoperative plain radiographic and three-dimensional CT images were enrolled in this study. Following the Revised AO/OTA Classification, three individual observers initially classified the fractures in plain radiograph images as either Stable (A1) or Unstable (A2). Subsequently, they further categorized them into five sub-categories (A1.1, A1.2, A1.3, A2.2, and A2.3). The same classification system was applied to the CT scan images. Inter-observer agreement and consistency of fracture classification between plain radiographs and CT scan images were assessed. Results The inter-observer agreement for fractures classified as stable or unstable using only plain radiographs was found to be fair among the three observers, with a mean κ of 0.397 (95% CI: 0.316-0.478). However, inter-observer agreement improved significantly when using CT scans, with a mean κ of 0.590 (95% CI: 0.518-0.662). Our results demonstrated a consistency level between two graphical modalities ranging from fair to moderate, with κ values of 0.581, 0.383, and 0.335, respectively. It's worth noting that plain radiographic classification occasionally resulted in underestimations, with each observer identifying 16.1%, 34.0%, and 37.9%, respectively, of cases as A1 in plain radiographs that were classified as A2 in CT scans. Conclusions This study reveals a moderate to substantial level of inter-observer agreement for fracture classification when using CT scan images, in contrast to plain radiographs. Fracture evaluation relying solely on plain radiographs sometimes underestimates fracture classification and exhibits less consistency compared to using CT scan images.

  Nov. 2023, Cureus, 15(11) (11), e48413, English, International magazine

  Scientific journal


• Timing of retears after arthroscopic rotator cuff repair and associated factors: a retrospective analysis.

  Kohei Yamaura, Isao Fujibayashi, Takashi Kurosawa, Yutaka Mifune, Atsuyuki Inui, Takuma Ozaki, Makoto Mitani

  BACKGROUND: Retear after arthroscopic rotator cuff repair (ARCR) remains a complication of important concern. Few reports have evaluated retear timing and its associated patient characteristics in large cohorts. This study aimed to investigate retear timing and patient characteristics and factors associated with this parameter. METHODS: Of the 638 consecutive shoulders that underwent ARCR from August 2009 to November 2019, shoulders with retear complication within 1 year of surgery were included. Retears were defined as type IV or V of the Sugaya's classification, and magnetic resonance imaging was performed at 6 weeks, 3 months, 6 months, and 1 year after surgery. The distribution of patients with retears at the timing of retears was investigated. In addition, patients with retears were classified into the following two groups: early group with retears occurring at 6 weeks and 3 months postoperatively or late group with retears occurring between 6 months and 1 year postoperatively. Associated factors such as sex, age, tear size, pre and postoperative range of motion, surgical technique, and clinical outcome between the two groups were investigated. RESULTS: The 41 shoulders with retears were divided into four groups: 1) within 6 weeks after surgery (n = 9, 22.0%), 2) 6 weeks-to 3 months after surgery (n = 19, 46.3%), 3) 3-6 months after surgery (n = 11, 26.8%), and 4) 6 months-1 year after surgery (n = 2, 4.9%). In addition, there were significantly larger retear sizes in the Sugaya's classification in the early group compared to the late group (P = .013), while there were significantly more males in the late group compared to the early group (P = .030). CONCLUSION: The highest retear rate after ARCR was observed from 6 weeks to 3 months after surgery, with equivalent rates within 6 weeks and from 3 months to 6 months after surgery.

  Sep. 2023, Journal of shoulder and elbow surgery, 32(9) (9), 1929 - 1936, English, International magazine

  Scientific journal


• 上腕骨近位端骨折続発症に対するリバース型人工肩関節置換術の小経験

  牟田口 由紀子, 美舩 泰, 乾 淳幸, 西本 華子, 黒田 良祐

  当院で2021～2022年に上腕骨近位端骨折続発症に対してRSAを施行した7例の成績を報告した。男性1例、女性6例、手術時年齢は平均78.9歳、Boileau分類タイプ1が1例、タイプ3が5例、タイプ4が1例、初回骨折からRSAまでの期間は平均30.4ヵ月であった。JOAスコアは術前平均39.7点から術後78.9点に改善し、UCLAスコアは術前平均8点から術後24.1点に改善、Constantスコアは術前平均15.1点から術後42点に改善した。自動可動域は屈曲が術前平均34.3°から術後91.7°に改善し、外転が術前平均31.4°から術後95°に改善、外旋が術前平均0.7°から術後33.3°に改善した。これらの成績から上腕骨近位端骨折続発症に対してRSAは有用と考えられたが、過去に報告された腱板断裂や変形性肩関節症に対するRSAの成績と比較すると術後可動域が不良であり、成績向上のためには結節部の保護や解剖学的な修復が必要と考えられた。

  (一社)中部日本整形外科災害外科学会, Sep. 2023, 中部日本整形外科災害外科学会雑誌, 66(5) (5), 727 - 728, Japanese


• Measurement of Shoulder Abduction Angle with Posture Estimation Artificial Intelligence Model.

  Masaya Kusunose, Atsuyuki Inui, Hanako Nishimoto, Yutaka Mifune, Tomoya Yoshikawa, Issei Shinohara, Takahiro Furukawa, Tatsuo Kato, Shuya Tanaka, Ryosuke Kuroda

  Substantial advancements in markerless motion capture accuracy exist, but discrepancies persist when measuring joint angles compared to those taken with a goniometer. This study integrates machine learning techniques with markerless motion capture, with an aim to enhance this accuracy. Two artificial intelligence-based libraries-MediaPipe and LightGBM-were employed in executing markerless motion capture and shoulder abduction angle estimation. The motion of ten healthy volunteers was captured using smartphone cameras with right shoulder abduction angles ranging from 10° to 160°. The cameras were set diagonally at 45°, 30°, 15°, 0°, -15°, or -30° relative to the participant situated at a distance of 3 m. To estimate the abduction angle, machine learning models were developed considering the angle data from the goniometer as the ground truth. The model performance was evaluated using the coefficient of determination R2 and mean absolute percentage error, which were 0.988 and 1.539%, respectively, for the trained model. This approach could estimate the shoulder abduction angle, even if the camera was positioned diagonally with respect to the object. Thus, the proposed models can be utilized for the real-time estimation of shoulder motion during rehabilitation or sports motion.

  Jul. 2023, Sensors (Basel, Switzerland), 23(14) (14), English, International magazine

  Scientific journal


• Diagnosis of Developmental Dysplasia of the Hip by Ultrasound Imaging Using Deep Learning.

  Maki Kinugasa, Atsuyuki Inui, Shinichi Satsuma, Daisuke Kobayashi, Ryosuke Sakata, Masayuki Morishita, Izumi Komoto, Ryosuke Kuroda

  BACKGROUND: A timely diagnosis of developmental dysplasia of the hip (DDH) is important for satisfactory clinical outcomes. Ultrasonography is a useful tool for DDH screening; however, it is technically demanding. We hypothesized that deep learning could assist in the diagnosis of DDH. In this study, several deep-learning models were assessed to diagnose DDH on ultrasonograms. This study aimed to evaluate the accuracy of diagnoses made by artificial intelligence (AI) using deep learning on ultrasound images of DDH. METHODS: Infants who were up to 6 months old with suspected DDH were included. DDH diagnosis using ultrasonography was performed according to the Graf classification. Data on 60 infants (64 hips) with DDH and 131 healthy infants (262 hips) obtained from 2016 to 2021 were retrospectively reviewed. For deep learning, a MATLAB deep learning toolbox (MathWorks, Natick, MA, US) was used, and 80% of the images were used as training data, with the rest as validation data. Training images were augmented to increase data variation. In addition, 214 ultrasound images were used as test data to evaluate the AI's accuracy. Pre-trained models (SqueezeNet, MobileNet_v2, and EfficientNet) were used for transfer learning. Model accuracy was evaluated using a confusion matrix. The region of interest of each model was visualized using gradient-weighted class activation mapping (Grad-CAM), occlusion sensitivity, and image LIME. RESULTS: The best scores for accuracy, precision, recall, and F-measure were all 1.0 in each model. In DDH hips, the region of interest for deep learning models was the area lateral to the femoral head, including the labrum and joint capsule. However, for normal hips, the models highlighted the medial and proximal areas where the lower margin of the os ilium and the normal femoral head exist. CONCLUSIONS: Ultrasound imaging with deep learning can assess DDH with high accuracy. This system could be refined for a convenient and accurate diagnosis of DDH. LEVEL OF EVIDENCE: Level-Ⅳ.

  May 2023, Journal of pediatric orthopedics, English, International magazine

  Scientific journal


• Dynamic Analysis of the Coracohumeral Ligament Using Ultra-Sonography in Shoulder Contracture.

  Tatsuo Kato, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Tomoya Yoshikawa, Issei Shinohara, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Ryosuke Kuroda

  The coracohumeral ligament (CHL) is related to the range of motion of the shoulder joint. The evaluation of the CHL using ultrasonography (US) has been reported on the elastic modulus and thickness of the CHL, but no dynamic evaluation method has been established. We aimed to quantify the movement of the CHL by applying Particle Image Velocimetry (PIV), a technique used in the field of fluid engineering, to cases of shoulder contracture using the US. The subjects were eight patients, with 16 shoulders. The coracoid process was identified from the body surface, and a long-axis US image of the CHL parallel to the subscapularis tendon was drawn. The shoulder joint was moved from 0 degrees of internal/external rotation to 60 degrees of internal rotation at a rhythm of one reciprocation every 2 s. The velocity of the CHL movement was quantified by the PIV method. The mean magnitude velocity of CHL was significantly faster on the healthy side. The maximum magnitude velocity was significantly faster on the healthy side. The results suggest that the PIV method is helpful as a dynamic evaluation method, and in patients with shoulder contracture, the CHL velocity was significantly decreased.

  Apr. 2023, Sensors (Basel, Switzerland), 23(8) (8), English, International magazine

  Scientific journal


• Elicitation of Inhibitory Effects for AGE-Induced Oxidative Stress in Rotator Cuff-Derived Cells by Apocynin.

  Takahiro Furukawa, Takashi Kurosawa, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Yasuhiro Ueda, Takeshi Kataoka, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Issei Shinohara, Tatsuo Kato, Shuya Tanaka, Masaya Kusunose, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  Advanced glycation end-products (AGEs) play a critical supportive role during musculoskeletal disorders via glycosylation and oxidative stress. Though apocynin, identified as a potent and selective inhibitor of NADPH oxidase, has been reported to be involved in pathogen-induced reactive oxygen species (ROS), its role in age-related rotator cuff degeneration has not been well clarified. Therefore, this study aims to evaluate the in vitro effects of apocynin on human rotator cuff-derived cells. Twelve patients with rotator cuff tears (RCTs) participated in the study. Supraspinatus tendons from patients with RCTs were collected and cultured. After the preparation of RC-derived cells, they were divided into four groups (control group, control + apocynin group, AGEs group, AGEs + apocynin group), and gene marker expression, cell viability, and intracellular ROS production were evaluated. The gene expression of NOX, IL-6, and the receptor for AGEs (RAGE) was significantly decreased by apocynin. We also examined the effect of apocynin in vitro. The results showed that ROS induction and increasing apoptotic cells after treatment of AGEs were significantly decreased, and cell viability increased considerably. These results suggest that apocynin can effectively reduce AGE-induced oxidative stress by inhibiting NOX activation. Thus, apocynin is a potential prodrug in preventing degenerative changes of the rotor cuff.

  Apr. 2023, Current issues in molecular biology, 45(4) (4), 3434 - 3445, English, International magazine

  Scientific journal


• Comparative Study of Different Entry Spots on Postoperative Gluteus Medius Muscle Cross-Sectional Area in Patients With Intertrochanteric Fractures Nailing.

  Mitsuaki Noda, Shunsuke Takahara, Atsuyuki Inui, Keisuke Oe, Shin Osawa, Takehiko Matsushita

  Introduction In a preliminary study of cephalo-medullary (CM) nailing in patients with femoral intertrochanteric fractures, the authors of this study found a 25% to 30% decrease in muscle strength, especially abduction force, during the postoperative follow-up period. This decline was partially attributed to the entry point for the nail insertion causing damage to the gluteus medius tendon at the junction of the greater trochanter after reaming. Therefore, we assumed that changing the position of nail insertion to a "bald spot (BS)" could mitigate postoperative functional impairment. Automated computed tomography (CT) imaging of skeletal muscle cross-sectional area (CSA) and adipose tissue ratio (ATR) can show pathological changes on the operated side compared with the non-operated side. In this study, the authors quantified the difference in postoperative CSA and ATR of the gluteus medius muscle after bald spot nailing versus nail insertion through the conventional tip of the greater trochanter. It was hypothesized that bald spot nailing could avoid significant injury to the gluteus medius muscle. Materials and methods Patients with femoral intertrochanteric fractures were grouped according to the site of cephalo-medullary nailing: greater trochanteric tip (TIP) in 27 patients (8 men and 19 women, mean age 84.9±5.1 years) and BS in 16 patients (3 men and 13 women, mean age 86.9±6.2 years). The CSA and ATR of the gluteus medius muscles were assessed in three slices (A, B, and C from proximal to distal). Each slice was manually traced and automatically calculated based on its contour. Adipose tissue (-100 to -50 in Hounsfield units) in the designated area was distinguished by a bimodal image histogram resulting from the distribution of CT numbers of adipose tissue and muscle. The body mass index (BMI) was used to correct the CSA in each patient. Results In the TIP group, the mean CSA values (mm2) from the non-operated/operated sides were as follows: slice A, 2180.2 ± 616.5/1976.3 ± 421.2; slice B, 2112.3 ± 535.7/1857.7 ± 386.7; and slice C: 1671.8 ± 460.0/1404.1 ± 404.3 (p<0.01 in slices A, B, and C). In the BS group, slice A was 2044.1 ± 473.0/2016.9 ± 388.4; slice B was 2073.2 ± 540.7/1848.3 ± 411.1; and slice C was 1659.1 ± 477.2/1468.5 ± 341.7 (p=0.34 in slice A, and p<0.05 in slices B and C, respectively). The mean CSA values (mm2) of the non-operated minus operated side between the TIP/BS groups were as follows: slice A, 241.3 ± 424.3/-11.8 ± 285.6; slice B, 290.3 ± 313.0/211.8 ± 333.2; and slice C, 276.4 ± 270.4/162.8 ± 319.3 (p < 0.05 in slice A, 0.45, 0.24 in slices B, C, respectively). The mean adjusted CSA per BMI values (mm2) of the non-operated minus the operated side between the TIP/BS groups were slice A, 10.6 ± 19.7/-0.4 ± 14.8; slice B, 13.3 ± 15.0/10.1 ± 16.3; and slice C, 13.1 ± 13.4/ 8.7 ± 15.3 (p < 0.05 in slice A and 0.54 and 0.36 in slices B and C, respectively). Conclusion Nail insertion at the bald spot resulted in a significantly smaller decrease in the CSA of the gluteus medius muscle compared with the conventional tip entry. In addition, an examination of BMI-adjusted CSA showed that CSA was maintained in some image slices. These results suggest that nailing from the BS of the greater trochanter can reduce damage to the gluteus medius muscle and highlight the importance of imaging beyond the usual assessment of skeletal changes.

  Mar. 2023, Cureus, 15(3) (3), e36103, English, International magazine

  Scientific journal


• Foveal Triangular Fibrocartilage Complex Tear Repair with Nonabsorbent Suture Tape.

  Issei Shinohara, Atsuyuki Inui, Yutaka Mifune, Kohei Yamaura, Shintaro Mukohara, Ryosuke Kuroda

  PURPOSE: Arthroscopic repair is performed for fovea injuries of the triangular fibrocartilage complex (TFCC) when instability of the distal radioulnar joint results in pain, decreased grip strength, and mechanical symptoms. During TFCC repair, reconstruction of its attachment to the fovea is important. Nonabsorbent suture tapes have gained attention for ligament repair in the trapeziometacarpal joint, scapholunate ligament, and thumb metacarpophalangeal ligament. However, there are no reports of TFCC repair using suture tapes. We evaluated the early postoperative results of this approach. METHODS: Participants underwent arthroscopic suture tape repair of foveal TFCC tears and were observed for more than 1 year. All repairs were performed using suture tapes and an outside-in technique with a bone tunnel from the ulnar shaft to the fovea. The postoperative complications, postoperative wrist range of motion, grip strength, and the Modified Mayo Score were evaluated. RESULTS: Arthroscopic repair with a suture tape was performed for 20 hands using the outside-in technique. The ranges of motion for the operated and nonoperated hands were comparable 1 year after surgery (pronation, 84° ± 4°; supination, 83° ± 4°). The mean grip strength improved from 65% ± 13% before surgery to 89% ± 9% after a year. The mean Modified Mayo Score improved from 58 ± 11 before surgery to 91 ± 8 after a year. Postoperative complications included abnormal sensation of the dorsal ulnar side in 2 hands. CONCLUSIONS: After using a suture tape to attach the TFCC to the fovea, satisfactory function was achieved in the early postoperative period with grip strength restoration. For the repair of foveal TFCC tears, attachment to the ulnar fovea is important, and repair by a suture tape may be useful. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.

  Feb. 2023, The Journal of hand surgery, English, International magazine

  Scientific journal


• Screening for Osteoporosis from Blood Test Data in Elderly Women Using a Machine Learning Approach.

  Atsuyuki Inui, Hanako Nishimoto, Yutaka Mifune, Tomoya Yoshikawa, Issei Shinohara, Takahiro Furukawa, Tatsuo Kato, Shuya Tanaka, Masaya Kusunose, Ryosuke Kuroda

  The diagnosis of osteoporosis is made by measuring bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA). Machine learning, one of the artificial intelligence methods, was used to predict low BMD without using DXA in elderly women. Medical records from 2541 females who visited the osteoporosis clinic were used in this study. As hyperparameters for machine learning, patient age, body mass index (BMI), and blood test data were used. As machine learning models, logistic regression, decision tree, random forest, gradient boosting trees, and lightGBM were used. Each model was trained to classify and predict low-BMD patients. The model performance was compared using a confusion matrix. The accuracy of each trained model was 0.772 in logistic regression, 0.739 in the decision tree, 0.775 in the random forest, 0.800 in gradient boosting, and 0.834 in lightGBM. The area under the curve (AUC) was 0.595 in the decision tree, 0.673 in logistic regression, 0.699 in the random forest, 0.840 in gradient boosting, and 0.961, which was the highest, in the lightGBM model. Important features were BMI, age, and the number of platelets. Shapley additive explanation scores in the lightGBM model showed that BMI, age, and ALT were ranked as important features. Among several machine learning models, the lightGBM model showed the best performance in the present research.

  Feb. 2023, Bioengineering (Basel, Switzerland), 10(3) (3), English, International magazine

  Scientific journal


• Degree of Accuracy With Which Deep Learning for Ultrasound Images Identifies Osteochondritis Dissecans of the Humeral Capitellum.

  Issei Shinohara, Tomoya Yoshikawa, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Shintaro Mukohara, Tatsuo Kato, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Medical screening using ultrasonography (US) has been performed on young baseball players for early detection of osteochondritis dissecans (OCD) of the humeral capitellum. Deep learning (DL) and artificial intelligence (AI) techniques are widely adopted in the medical imaging research field. PURPOSE/HYPOTHESIS: The purpose of this study was to calculate the diagnostic accuracy using DL for US images of OCD. We hypothesized that using DL for US imaging would improve the prediction accuracy of OCD. STUDY DESIGN: Cohort study (Diagnosis); Level of evidence, 2. METHODS: A total of 40 elbows (mean age of patients, 12.1 years) that were suspected of having OCD at a medical checkup and later confirmed by radiographs and magnetic resonance imaging were included in the study. The affected elbows were used as the OCD group and the contralateral elbows as the control group. From US videos, 100 images per elbow were captured from different angles, and 4000 images of the elbows were prepared for both groups. Of these, 80% were randomly selected by DL models and used as training data; the remaining were used as test data. Transfer learning was conducted using 3 pretrained DL models. The confusion matrix and the area under the receiver operating characteristic curve (AUC) were used to evaluate the model, and the visualization of the areas deemed important by the DL models was also performed. Furthermore, OCD regions were detected using an automatic image recognition model based on DL. RESULTS: Classification of the OCD image by the DL model was performed; the best accuracy score was 0.87; the recall was 1.00. AUC was high for all DL models. Visualization of important features showed that AI predicted the presence of OCD by focusing on the irregularity or discontinuity of the surface of subchondral bone. In the detection of OCD task, the mean average precision was 0.83. CONCLUSION: The DL on US images identified OCD with high accuracy. The important features detected by the DL models correspond to the areas used by clinicians in screening the US images. The OCD was also detected with high accuracy using the object detection model. The AI model may be used in medical screening for OCD.

  Feb. 2023, The American journal of sports medicine, 51(2) (2), 358 - 366, English, International magazine

  Scientific journal


• Anatomical Assessment of Cephalic Vein and Superficial Branch of Radial Nerve Using High-Resolution Ultrasound Imaging

  Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Shintaro Mukouhara, Tomoya Yoshikawa, Ryosuke Kuroda

  Elsevier BV, 2023, Journal of Hand and Microsurgery, 15(1) (1), 41 - 44

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Demographic Survey of Pertrochanteric Fractures Based on the Revised Arbeitsgemeinschaft für Osteosynthesefragen/Orthopedic Trauma Association (AO/OTA) Classification Using 3D CT Scan Images.

  Mitsuaki Noda, Shunsuke Takahara, Ryota Nishida, Keisuke Oe, Atsuyuki Inui, Shin Osawa, Takehiko Matsushita

  Introduction A demographic survey of femoral pertrochanteric fractures provides several important information for the healthcare system of a country since this fracture is commonly seen in the elderly and has a poor postoperative functional prognosis that is a burden on society. The importance of accurately classifying pertrochanteric fractures as stable or unstable cannot be understated. However, the use of plain radiograph images alone is known to underestimate fracture severity with low inter- or intra-observer agreement. Computed tomography (CT) images offer information for a more accurate classification of pertrochanteric fractures. With this three-dimensional (3D) CT-based study using the revised Arbeitsgemeinschaft für Osteosynthesefragen/Orthopedic Trauma Association (AO/OTA) classification, the purpose of this study is to elucidate the epidemiological demography of patients with pertrochanteric fractures. Material and methods We retrospectively collected 808 patients from five hospitals, classified into two groups: stable (A1) or unstable (A2). Age, gender, fracture laterality, and surgery timing were identified as epidemiological variables. Patients with both preoperative plain radiographs and 3D CT scans were included in the study. The exclusion criteria were AO/OTA A3 type fractures, pathological fractures, previous ipsilateral surgery, 60 years old or younger, and conservatively treated patients. The primary outcome involved detailing the total number of fractures based on classification (A1 or A2) and variables. The secondary outcome involved a comparison between the A1 and A2 groups. Results The mean age of patients at the time of surgery was 85 years (range: 61-103 years). There were 637 female and 171 male patients. There were 463 left-sided fractures and 345 right-sided fractures. Of the 808 patients, 371 (45.9%) were classified to have A1 fractures, and 437 (54.1%) had A2 fractures. The age at surgery, gender, fracture laterality, and surgery timing between the A1 and A2 groups were compared. The mean and standard deviation of the age at surgery for patients in the A1 and A2 groups were 84.9±7.7 and 86.9±6.8, respectively. The number of patients for each age distribution of 61-69, 70-74, 75-79, 80-84, 85-89, 90-94, and 95 or older for the A1 and A2 groups was 18 and 7, 18 and 12, 43 and 44, 76 and 82, 107 and 132, 79 and 110, and 30 and 50, respectively, showing that the difference in categorial distribution was statistically significant (p=0.002). Overall, 278 females and 93 males were classified to have A1 fractures compared with 359 females and 78 males with A2 fractures (p=0.01). There were 166 right-sided and 205 left-sided stable A1 fractures and 179 right-sided and 258 left-sided A2 fractures (not significant (NS)). Among the total number of A1 and A2 surgeries by month, the most were in December with 77 surgeries (37 and 40, respectively), and the least was in June with 37 (18 and 19, respectively). The seasonal classification for A1 and A2 surgeries is as follows: spring with 172 (74 and 98, respectively), summer with 150 (70 and 80, respectively), autumn with 193 (90 and 103, respectively), and winter with 208 (97 and 111, respectively) (NS). Conclusion In this demographic study of 808 patients with pertrochanteric fractures classified by 3D CT images, 371 had A1 fractures and 437 had A2 fractures. A2 fractures were significantly more in females with an age peak of 85-89 years.

  Jan. 2023, Cureus, 15(1) (1), e33572, English, International magazine

  Scientific journal


• Sex Is Associated with the Success or Failure of Manipulation Alone for Joint Stiffness Associated with Rotator Cuff Repair.

  Kohei Yamaura, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Shintaro Mukohara, Tomoya Yoshikawa, Issei Shinohara, Tatsuo Kato, Takahiro Furukawa, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  Purpose: One-stage arthroscopic rotator cuff repair with manipulation has been recently performed for rotator cuff tears with shoulder stiffness, whereas some patients require capsular release due to severe stiffness that is difficult to treat with manipulation. The purpose of this study was to analyze patient backgrounds and related factors of success or failure of manipulation alone for the treatment of shoulder stiffness associated with rotator cuff tears. Methods: This study included 64 patients with rotator cuff tears and shoulder stiffness who underwent arthroscopic rotator cuff repair with manipulation alone or with manipulation and capsular release of the glenohumeral joint at our institution between January 2015 and September 2019. The patients were divided into two groups: those whose shoulder stiffness could be improved by manipulation alone (Manipulation group) and those whose stiffness could not be improved by manipulation alone and required capsular release (Capsular release addition group). Analysis was performed between the two groups regarding patient backgrounds and related factors, including rotator cuff tear morphology and range of motions pre- and postoperatively. Results: Exactly 45 patients and 19 patients were included in Manipulation group and Capsular release addition group, respectively. A comparison between the two groups showed that patient age (p = 0.0040), sex (p = 0.0005), and injury due to trauma (p = 0.0018) were significantly related to the success or failure of manipulation alone. Multivariate logistic regression analysis on these three factors showed that sex (odds ratio, 5.5; p = 0.048) was significantly associated with the success or failure of manipulation alone. In both groups, the passive ROM of all patients improved at the last postoperative follow-up compared to their pre-operative values (p < 0.001), except for internal rotation in the Capsular release addition group (p = 0.49). Conclusion: Young male patients who have shoulder stiffness associated with rotator cuff tears should be considered for arthroscopic capsular release rather than manipulation.

  Dec. 2022, Journal of clinical medicine, 11(23) (23), English, International magazine

  Scientific journal


• Novel therapy using a fish scale collagen scaffold for rotator cuff healing in rat models.

  Kohei Yamaura, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Shintaro Mukohara, Tomoya Yoshikawa, Issei Shinohara, Tatsuo Kato, Takahiro Furukawa, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Large and massive rotator cuff tears are challenging for surgeons because of postoperative complications such as repaired site retears. Recently, collagen extracted from fish scales has gained more attention because fish byproducts are considered a safer collagen source than other animal-derived scaffolds. This study aimed to evaluate the biological efficacy of tilapia scale-derived collagen scaffolds for rotator cuff repair in rat models. METHODS: The infraspinatus tendon was resected from the greater tuberosity of Sprague-Dawley rats. In the control group, the tendon edge was sutured directly to the humeral head. In the augmentation group, the repaired site was augmented with a tilapia scale-derived collagen scaffold. Histologic examinations were performed at 2 and 4 weeks postoperatively via safranin O and immunofluorescence staining (isolectin B4 and type II collagen) in the bone-tendon junction. For mechanical analysis, the ultimate failure load of the tendon-humeral head complex was evaluated at 6 weeks postoperatively. RESULTS: During safranin O staining, the repaired enthesis demonstrated greater proteoglycan staining in the augmentation group than in the control group at 4 weeks postoperatively. Compared to controls, the augmentation group had significantly higher vascular staining with isolectin B4 at 2 and 4 weeks postoperatively, type II collagen expression at 4 weeks postoperatively, and ultimate failure load at 6 weeks postoperatively. CONCLUSION: Augmentation therapy using tilapia scale-derived type I collagen scaffolds promoted angiogenesis and fibrocartilage regeneration at the enthesis and provided higher mechanical strength than controls.

  Dec. 2022, Journal of shoulder and elbow surgery, 31(12) (12), 2629 - 2637, English, International magazine

  Scientific journal


• Assessment of the Ulnar Collateral Ligament of the Elbow Using Ultrasonic Shear Wave Elastography in Professional Baseball Players.

  Tomoya Yoshikawa, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Kohei Yamaura, Shintaro Mukohara, Issei Shinohara, Yuichi Hoshino, Takehiko Matsuishita, Ryosuke Kuroda

  BACKGROUND: Injury to the ulnar collateral ligament (UCL) of the elbow can cause chronic pain and loss of throwing ability. Ultrasonic shear wave elastography (SWE) is a new imaging method that can be used for quantitative assessment of tissue elasticity. PURPOSE: To evaluate the properties of the UCL in professional baseball players using SWE. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: This study included 35 professional baseball players (mean age, 23.0 years) without elbow injuries. Both elbows of each player were examined using ultrasound, and comparisons between the dominant and nondominant arms were conducted. The thickness of the anterior bundle of the UCL at its midportion was measured in the resting position on ultrasound. We also measured the difference in the ulnohumeral joint space with and without gravity stress on the forearm. Tissue elasticity was evaluated using a built-in software program. The relationship between UCL elasticity and ultrasound findings was analyzed using the Pearson correlation coefficient. RESULTS: The mean ± SD thickness of the UCL was significantly greater in the dominant arm versus the nondominant arm (6.0 ± 1.4 vs 5.3 ± 1.3 mm; P = .004). The mean joint space difference was significantly wider in the dominant arm as compared with the nondominant arm (0.81 ± 0.42 vs 0.52 ± 0.31 mm; P = .002), and the mean UCL elasticity was lower in the dominant arm than in the nondominant arm (34.9 ± 11.6 vs 43.3 ± 10.6 kPa; P = .002). UCL elasticity was negatively correlated with UCL thickness (r = -0.27; P = .02) and joint space difference (r = -0.34; P = .003). CONCLUSION: In professional baseball players, the elbow UCL of the dominant arm demonstrated increased thickness, with a larger joint space gap on gravity stress and lower elasticity in SWE as compared with the nondominant arm. Greater medial joint laxity can be predicted by assessing the elasticity of the UCL using SWE.

  Dec. 2022, Orthopaedic journal of sports medicine, 10(12) (12), 23259671221138134 - 23259671221138134, English, International magazine

  Scientific journal


• Posterior Protrusion Measures (PPM) as an Innovative Index in Classifying Plain Lateral Radiograph Images of Pertrochanteric Fracture Using the Revised AO Foundation/Orthopaedic Trauma Association (AO/OTA) Classification.

  Mitsuaki Noda, Shunsuke Takahara, Atsuyuki Inui, Keisuke Oe, Shin Osawa, Takehiko Matsushita

  Introduction The absence of a precise fracture classification system that classifies pertrochanteric fractures into either stable or unstable contributes to a burden on healthcare and has several major implications. We propose an innovative graphical index, which we refer to as posterior protrusion measures (PPM), using plain lateral view radiograph images for the revised AO Foundation (Arbeitsgemeinschaft für Osteosynthesesfragen)/Orthopedic Trauma Association (AO/OTA) classification system. This study aims to: (i) introduce the use of PPM for classifying fractures into stable or unstable under the revised AO/OTA classification system and set the threshold numeric value, (ii) elucidate the reproducibility of inter and intra-observer agreement, and investigate the consistency of fracture classification using PPM versus computed tomography (CT) scan images. Materials and methods Out of 146 patients identified from the database, a total of 126 patients were enrolled in the study. Pertrochanteric fractures were classified as either stable or unstable. Three surgeons were assigned for PPM determination. Regarding the demographical data, the chi-square test was used to assess the significance of each parameter on a categorical scale between the two groups. The independent sample t-test or the Mann-Whitney U test was used to compare the two independent groups. Interclass correlation coefficient (ICC) values for continuous variables and kappa values (κ) for categorical variables were calculated to assess inter-observer and intra-observer agreement. Receiver-operating characteristic (ROC) analysis was used to determine optimal cut-off points of PPM to predict consistency between separate fracture classification groups, one using PPM values with a threshold derived from plain radiograph images, and the other using CT scan images. Results Among a total of 126 pertrochanteric fractures, the A1 (stable) group consisted of 39 patients (10 males, 29 females), whereas the A2 (unstable) group consisted of 87 patients (14 males, 73 females) (not significant, NS). Intraclass correlation coefficient (ICC) values of PPM for the inter-observer agreement were 0.796 (0.723-0.852), 0.664 (0.554-0.751), and 0.702 (0.601-0.781) at first examination and 0.729 (0.635-0.801) at the second. The intra-observer agreement was 0.869 (0.819-0.906) and 0.603 (0.480-0.703). We examined for consistency of fracture classification group of PPM values with a threshold of 0.4 (A1<0.4, A2=0.4 or more) and CT-based group. For the first examination, there was mostly "moderate" agreement in fracture classification (stable or unstable) between plain radiograph and CT scan images, κ (95%CI): 0.427 (0.266-0.588), 0.493 (0.335-0.651), and 0.359 (0.176-0.544), and for the second, 0.418 (0.251-0.585), and 0.451 (0.284-0.620), respectively. Conclusion We propose a supplementary tool, namely PPM that allows for possible alternative classification of pertrochanteric fractures into A1 (stable) and A2 (unstable) using plain radiograph images under the revised AO/OTA classification system. In this study, a PPM threshold value of 0.4 demonstrated a moderate inter- and intra-observer agreement. It is noteworthy to mention that there was a satisfactory consistency of fracture classification using PPM derived from plain radiograph images when compared to classification using CT scan images. In addition, the PPM method provides a numerical score.

  Dec. 2022, Cureus, 14(12) (12), e32898, English, International magazine

  Scientific journal


• Motion Analysis of the Extensor Carpi Ulnaris in Triangular Fibrocartilage Complex Injury Using Ultrasonography Images.

  Shuya Tanaka, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Tomoya Yoshikawa, Issei Shinohara, Takahiro Furukawa, Tatsuo Kato, Masaya Kusunose, Ryosuke Kuroda

  The subsheath of the extensor carpi ulnaris (ECU) tendon, a component of the triangular fibrocartilage complex (TFCC), is particularly important as it dynamically stabilizes the distal radioulnar joint. However, the relationship between TFCC injury and ECU dynamics remains unclear. This study aimed to analyze ECU movement and morphology using ultrasonography (US) images. Twenty wrists of patients with TFCC injury, who underwent TFCC repair, were included in the injury group, and 20 wrists of healthy volunteers were in the control group. For static image analysis, curvature and linearity ratios of the ECU in US long-axis images captured during radioulnar deviation were analyzed. For dynamic analysis of the ECU, the wrist was moved from radial deviation to ulnar deviation at a constant speed, and the velocity of the tendon was analyzed using particle image velocimetry. The static analysis showed that the ECU tendon was more curved in ulnar deviation in the injury group than in the control group, and the dynamic analysis showed that only vertical velocity toward the deep side during ulnar deviation was higher in the injury group. These results suggest that TFCC injury caused ECU curvature during ulnar deviation and increased the vertical velocity of the ECU during wrist deviation.

  Oct. 2022, Sensors (Basel, Switzerland), 22(21) (21), English, International magazine

  Scientific journal


• Efficacy of Abductor Pollicis Longus Suspension Arthroplasty Combined With Mini TightRope for Osteoarthritis of Thumb Carpometacarpal Joint

  Kohei Yamaura, Atsuyuki Inui, Yutaka Mifune, Shintaro Mukohara, Takahiro Furukawa, Ryosuke Kuroda

  Background: We aimed to evaluate the efficacy of abductor pollicis longus (APL) suspension arthroplasty with trapeziectomy combined with first and second metacarpal fixation using suture button device. Methods: Thirteen patients (14 thumbs) who underwent APL suspension arthroplasty combined with suture button device for osteoarthritis of the carpometacarpal joint of the thumb (Eaton grade III: 6 and IV: 8 thumbs) at our institution between 2015 and 2019 and were followed up for more than 24 months were included in the study. Preoperative and postoperative range of motion (ROM) of radial and palmar abduction, grip and key pinch strength, visual analog scale (VAS) scores for pain, and the trapezial space ratio (TSR) on radiographic images before and after surgery were statistically examined. Results: The mean age of the patients was 59.6 ± 8.1 years, and the mean follow-up period was 45.4 ± 12.2 months. While grip and pinch strength did not significantly change between preoperative and final follow-up measurements, the ROM of radial and palmar abduction and the VAS score at the latest follow-up were significantly better than the preoperative values ( P < .05). The mean TSR immediately after surgery and at the latest follow-up was 0.28 ± 0.089 and 0.22 ± 0.084, respectively, indicating a mean reduction rate of 23.3 ± 15.2%. Conclusions: This surgical technique showed significant improvement in the ROM of radial and palmar abduction and the VAS score for pain, and the combined fixation of the first and second metacarpals with suture button device suppressed the subsidence of the first metacarpal.

  SAGE Publications, Sep. 2022, HAND, 19(3) (3), 419 - 425

  Scientific journal


• Assessment of the upper limb muscles in patients with Fukuyama muscular dystrophy: Noninvasive assessment using visual ultrasound muscle analysis and shear wave elastography

  Harada R, Taniguchi-Ikeda M, Nagasaka M, Tatsiuya Nishii, Atsuyuki Inui, Tetsushi Yamamoto, Ichiro Morioka, Ryosuke Kuroda, Kazumoto Iijima, Kandai Nozu, Yoshitada Sakai, Tatsushi Toda

  May 2022, Neuromuscular Disorders

  Link to Kobe Univ. Repository (Kernel)


• Biochemical Markers of Aging (Advanced Glycation End Products) and Degeneration Are Increased in Type 3 Rotator Cuff Tendon Stumps With Increased Signal Intensity Changes on MRI.

  Issei Shinohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Tatsuo Kato, Takahiro Furukawa, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Advanced glycation end products (AGEs) are end products of protein glycation that bind to the receptor for AGEs (RAGE) and activate nicotinamide adenine dinucleotide phosphate oxidase (NOX), resulting in increased oxidative stress and rotator cuff fragility. Stump classification using the signal intensity ratio of the tendon rupture site to the deltoid muscle in the coronal view of T2-weighted fat-suppressed magnetic resonance imaging (MRI) scans is an indicator of clinical outcomes after rotator cuff repair surgery. Comparing the signal intensities of the deltoid (D) and rotator cuff tears (C), Ishitani et al. classified C/D <0.8 as type 1, 0.8 to 1.3 as type 2, and >1.3 as type 3. HYPOTHESIS/PURPOSE: It was hypothesized that the oxidative stress and collagen degeneration that occur in the rotator cuff due to accumulation of AGEs can be assessed on MRI scans (stump classification). Therefore, this study aimed to compare AGE-related factors in the rotator cuff tear site tissues based on stump classification. STUDY DESIGN: Descriptive laboratory study. METHODS: The authors included 30 patients (11 with type 1, 9 with type 2, and 10 with type 3; mean age, 62.3 years) who underwent surgery for complete rotator cuff tears at our hospital. Tendon tissue was harvested from the torn rotator cuff site during surgery for tissue and cell evaluation. RESULTS: There was no significant difference in the mean age according to stump classification. The number of patients with diabetes was significantly larger in type 3 than in the other types (P < .05). Tissue evaluation showed significantly higher expression of AGE and RAGE staining in type 3 than in the other types (~6.7-fold; P < .01). Cell evaluation showed that the expression rates of reactive oxygen species and apoptosis were significantly higher in type 3 than in the other types (~4.3-fold; P < .01). Gene expression by real-time polymerase chain reaction showed significantly higher RAGE (~5.1-fold), NOX (~5.3-fold), and IL (~3.0-fold) in type 3 than in the other types (P < .05). CONCLUSION: Stump classification type 3 exhibited the highest accumulation of AGEs and the highest oxidative stress and apoptosis, suggesting a high degree of degeneration and inflammation. Imaging based on stump classification reflects the degeneration and fragility of the torn rotator cuff site. CLINICAL RELEVANCE: This study provides evidence of a relationship between stump classification, which reflects rotator cuff fragility on MRI, and pathologies related to advanced glycation end products.

  Apr. 2022, The American journal of sports medicine, 3635465221090649 - 3635465221090649, English, International magazine

  Scientific journal


• Ultrasound With Artificial Intelligence Models Predicted Palmer 1B Triangular Fibrocartilage Complex Injuries.

  Issei Shinohara, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Shintaro Mukohara, Tomoya Yoshikawa, Ryosuke Kuroda

  PURPOSE: To calculate the diagnostic accuracy from the confusion matrix using deep learning (DL) on ultrasound (US) images of Palmer 1B triangular fibrocartilage complex (TFCC) injury. METHODS: Twenty-nine wrists of 15 healthy volunteers (11 men; mean age, 34.9 years ± 9.7) (control group) and 20 wrists of 17 patients (11 men; mean age 41.0 years ± 12.2) with TFCC injury (Palmer type IB) (injury group) were included in the study. The diagnosis of Palmer 1B TFCC injury was made using magnetic resonance imaging, computed tomography arthrography, and intraoperative arthroscopic findings. In total, 2,000 images were provided to each group, 80% of which were randomly selected by AI and used as training data; the remaining data were used as test data. Transfer learning was conducted using a pretrained 3 separate models (GoogLeNet, ResNet50, ResNet101). Model evaluation was performed using a confusion matrix. The area under a receiver operating characteristic curve was also calculated. The occlusion sensitivity was used to visualize the important features. RESULTS: For the prediction of TFCC injury by the DL model, the best score of accuracy was 0.85 in GoogLeNet, a recall was 1.0 in ResNet50 and ResNet101, and a specificity was 0.78 in GoogLeNet. In predicting the TFCC injury for the test data, the best score of the AUC was 0.97 on ResNet101. Visualization of important features showed that AI predicted the presence of injury by focusing on the morphology of the articular disc. CONCLUSIONS: US images using the DL model predicted Palmer 1B TFCC injury with high accuracy, with the best scores of 0.85 for accuracy on GoogLeNet, 1.00 for sensitivity on ResNet50 and ResNet101, and 0.78 for specificity on GoogLeNet. The use of DL for US imaging of Palmer 1B TFCC injury predicted the injury as well as magnetic resonance imaging and computed tomography arthrography LEVEL OF EVIDENCE: IV; retrospective case series study.

  Apr. 2022, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, English, International magazine

  Scientific journal


• Influence of Diabetes-Induced Glycation and Oxidative Stress on the Human Rotator Cuff.

  Tomoya Yoshikawa, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Kohei Yamaura, Shintaro Mukohara, Issei Shinohara, Ryosuke Kuroda

  Most shoulder rotator cuff tears (RCTs) are caused by non-traumatic age-related rotator cuff degeneration, of which hyperglycemia is a risk factor due to its glycation reaction and oxidative stress. We aimed to identify the influence of diabetes-induced glycation and oxidative stress in patients with non-traumatic shoulder RCTs. Twenty patients, aged over 50 years, with non-traumatic shoulder RCTs participated in this study. Patients with a history of diabetes mellitus or preoperative HbA1c ≥ 6.5% were assigned to the diabetic group (n = 10), and the rest to the non-diabetic group (n = 10). Cell proliferation; expression of genes related to oxidative stress, glycation reaction, inflammation, and collagen; intracellular reactive oxygen species (ROS) levels; and apoptosis rates were analyzed. The diabetic group had significantly lower cell proliferation than the non-diabetic group. In the diabetic group, the mRNA expression levels of NOX1, NOX4, IL6, RAGE, type III collagen, MMP2, TIMP1, and TIMP2 were significantly higher; type I collagen expression was significantly lower; and the rate of ROS-positive cells and apoptotic cells, as well as the expression of advanced glycation end-products (AGEs) and the receptor for AGEs (RAGE), was significantly higher. In conclusion, hyperglycemia caused by diabetes mellitus increased AGE and RAGE expression, and led to increased NOX expression, ROS production, and apoptosis in the human rotator cuff. This provides scope to find a preventive treatment for non-traumatic RCTs by inhibiting glycation and oxidative stress.

  Apr. 2022, Antioxidants (Basel, Switzerland), 11(4) (4), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Advanced glycation end products are associated with limited range of motion of the shoulder joint in patients with rotator cuff tears associated with diabetes mellitus.

  Issei Shinohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Tatsuo Kato, Takahiro Furukawa, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Most degenerative rotator cuff tears (RCTs) are associated with a limited range of motion (ROM) of the shoulder joint. Additionally, patients with diabetes mellitus (DM) show a higher frequency of limited ROM. Recently, advanced glycation end products (AGEs) of proteins have been observed to cause tissue fibrosis, primarily through abnormal collagen cross-linking and oxidative stress. In this study, we investigated the effect of AGEs on ROM limitation in the shoulder capsule and its relationship with DM in the patients with RCTs. METHODS: Sixteen patients (eight in the DM and non-DM groups) who underwent arthroscopic surgery for RCT with limited shoulder ROM were included in this study. AGE-related pathologies in both groups were compared, and the relationship between AGE accumulation and shoulder joint ROM was evaluated. Shoulder capsule tissue was harvested and subjected to histological and in vitro evaluation. RESULTS: The DM group displayed high levels of AGEs and reactive oxygen species (ROS), and reduced cell viability. There was a significant positive correlation between ROS expression, apoptosis, and preoperative hemoglobin A1c. ROS expression, apoptosis, and ROM of the shoulder joint showed a negative correlation. The NADPH oxidase (NOX) expression and collagen III/I ratio were significantly higher in the DM group than in the non-DM group. CONCLUSIONS: The DM group showed significant AGEs deposition in the shoulder capsule. Additionally, there was a significant association between AGEs and ROM limitation. Collectively, the findings suggest that the oxidative stress induced by AGEs deposition, which leads to fibrosis and local inflammation, might contribute to the limited ROM of the shoulder joint in patients with RCTs accompanied by DM.

  Mar. 2022, BMC musculoskeletal disorders, 23(1) (1), 271 - 271, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Antioxidant effect of nicotinamide mononucleotide in tendinopathy.

  Kohei Yamaura, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Shintaro Mukohara, Yuichi Hoshino, Takahiro Niikura, Ryosuke Kuroda

  BACKGROUND: A link between tendinopathy and oxidative stress has been recently reported. Nicotinamide mononucleotide (NMN) is a precursor of nicotinamide adenine dinucleotide, which plays an important role in cell redox homeostasis. The aim of this study was to evaluate the antioxidant effect of NMN on tendinopathy in vitro and in vivo. METHODS: Tenocytes from healthy Sprague-Dawley rats were cultured in regular glucose (RG) and high-glucose (HG) conditions with or without NMN, and were divided into four groups: RG NMN(-), RG NMN(+), HG NMN(-), and HG NMN(+). Cell viability, reactive oxygen species (ROS) accumulation, apoptotic rate, and mRNA expression of nicotinamide adenine dinucleotide phosphate oxidase (NOX)1, NOX4, interleukin (IL)6, sirtuin (SIRT)1, and SIRT6 were investigated. In addition, rats with collagenase-induced tendinopathy were treated with or without NMN. Immunostaining of NOX1 and NOX4; mRNA expression of SIRT1, SIRT6, and IL6; and superoxide dismutase (SOD) activity measurements in the Achilles tendon were performed. RESULTS: NMN increased the expression of SIRT1 and SIRT6 in rat tenocytes, but decreased the levels of NOX1, NOX4, IL6, ROS, and apoptosis. In Achilles tendons with collagenase-induced tendinopathy, NMN increased the mRNA expression of SIRT1 and SIRT6, as well as SOD activity; while suppressing protein expression of NOX1 and NOX4, and mRNA expression of IL6. CONCLUSION: The in vitro and in vivo results of this study show that NMN exerts an antioxidant effect on tendinopathy by promoting the expression of SIRT while inhibiting that of NOX.

  Mar. 2022, BMC musculoskeletal disorders, 23(1) (1), 249 - 249, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Diagnosis of Cubital Tunnel Syndrome Using Deep Learning on Ultrasonographic Images.

  Issei Shinohara, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Tatsuo Kato, Takahiro Furukawa, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  Although electromyography is the routine diagnostic method for cubital tunnel syndrome (CuTS), imaging diagnosis by measuring cross-sectional area (CSA) with ultrasonography (US) has also been attempted in recent years. In this study, deep learning (DL), an artificial intelligence (AI) method, was used on US images, and its diagnostic performance for detecting CuTS was investigated. Elbow images of 30 healthy volunteers and 30 patients diagnosed with CuTS were used. Three thousand US images were prepared per each group to visualize the short axis of the ulnar nerve. Transfer learning was performed on 5000 randomly selected training images using three pre-trained models, and the remaining images were used for testing. The model was evaluated by analyzing a confusion matrix and the area under the receiver operating characteristic curve. Occlusion sensitivity and locally interpretable model-agnostic explanations were used to visualize the features deemed important by the AI. The highest score had an accuracy of 0.90, a precision of 0.86, a recall of 1.00, and an F-measure of 0.92. Visualization results show that the DL models focused on the epineurium of the ulnar nerve and the surrounding soft tissue. The proposed technique enables the accurate prediction of CuTS without the need to measure CSA.

  Mar. 2022, Diagnostics (Basel, Switzerland), 12(3) (3), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• DDHの超音波画像に対する深層学習モデルを用いた画像分類

  衣笠 真紀, 乾 淳幸, 坂田 亮介, 河本 和泉, 小林 大介, 薩摩 眞一, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S931 - S931, Japanese


• Co-occurring Acromioclavicular Joint Cyst and Hemarthrosis of the Shoulder Associated With Rotator Cuff Tear Arthropathy.

  Takanobu Higashi, Yutaka Mifune, Hanako Nishimoto, Atsuyuki Inui, Yuichi Hoshino, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda

  Both acromioclavicular joint (ACJ) cysts and hemarthrosis of the shoulder are rare conditions of massive rotator cuff tear that eventually lead to cuff tear arthropathy. We herein report the first case of a patient with co-occurring ACJ cyst and hemarthrosis of the shoulder. An 80-year-old right-hand-dominant man presented to our outpatient department with a six-month history of repeatable right shoulder pain and swelling. Clinical examination revealed a 5 x 5 x 5 cm elastic hard or hard shoulder lump overlying the ACJ on skin with subcutaneous bleeding and swelling of the shoulder. Shoulder pain at rest and a fully reduced active range of motion (ROM), particularly in flexion and abduction, were also noted. Radiographs demonstrated moderate degeneration of the glenohumeral joint including a bone cyst of the humeral head. Magnetic resonance imaging (MRI) revealed a massive rotator cuff tear with atrophy of the supraspinatus, infraspinatus, and subscapularis muscles. The T2-weighted MRI images showed that the cyst was in direct contact with the markedly degenerated glenohumeral joint. Based on these findings, the patient was diagnosed with massive rotator cuff tear with ACJ cyst and hemarthrosis of the shoulder. The patient underwent distal clavicle resection and reverse total shoulder arthroplasty (RSA). At 12-month follow-up, the patient showed no pain symptoms, no recurrence of the cyst, and excellent ROM. We experienced a very rare case of ACJ cyst and hemarthrosis of the shoulder occurring simultaneously with rotator cuff tear arthropathy. This report is very valuable in that it suggests that RSA is useful for both ACJ cysts and hemarthrosis of the shoulders associated with rotator cuff tear arthropathy.

  Mar. 2022, Cureus, 14(3) (3), e23353, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Preoperative Evaluation of Thenar Muscles in Carpal Tunnel Syndrome by Ultrasonography.

  Issei Nagura, Takako Kanatani, Yoshifumi Harada, Fumiaki Takase, Atsuyuki Inui, Yutaka Mifune, Ryosuke Kuroda

  This article aims to evaluate the usefulness of ultrasonography for the measurement of thenar muscles in carpal tunnel syndrome (CTS). A total of 85 patients with CTS who had a carpal tunnel release procedure were included in this study. The transducer was applied onto the palmar surface of the hand perpendicularly to the longitudinal axis of the first metacarpal bone. Thenar atrophy was evaluated visually and classified using the visual grading scale. A nerve conduction test was performed and classified according to the electrophysiological severity scale. This technique is more precise than visual evaluation because it is a quantitative assessment.

  Feb. 2022, Hand clinics, 38(1) (1), 55 - 58, English, International magazine

  Scientific journal


• Accuracy and reliability of tridimensional electromagnetic sensor system for elbow ROM measurement.

  Kohei Yamaura, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takeshi Kataoka, Takashi Kurosawa, Shintaro Mukohara, Yuichi Hoshino, Takahiro Niikura, Kouki Nagamune, Ryosuke Kuroda

  BACKGROUND: While the precise measurement of the range of motion (ROM) of the elbow joint is important for clinical assessment and rehabilitation, problems include low accuracy and reproducibility in goniometer measurements due to the influence of soft tissue. The purpose of this study was to validate elbow joint motion analysis using a three-dimensional electromagnetic sensor system (EMS). METHODS: The accuracy and reproducibility of the EMS system were evaluated at four angles (0°, 45°, 90°, and 135°) using a model bone of the humerus and forearm. In addition, the maximum extension and maximum flexion of six elbows of six healthy volunteers were assessed by radiographic and EMS measurements. Accuracy was assessed by calculating the mean value of the measurement angle, standard deviation, Pearson's correlation coefficient, and the Bland-Altman method. Reproducibility was assessed by calculating the intra-rater and inter-rater reliabilities using intraclass correlation coefficients. RESULTS: In the model bone evaluation, the mean angles of the EMS measurement were 1.2° ± 2.0°, 45.4° ± 2.1°, 91.7° ± 2.4°, and 134.6° ± 2.7° at 0°, 45°, 90°, and 135°, respectively. In the in vivo evaluation, the elbow angles at the maximum extension with the EMS and radiographic angles were 4.7° ± 3.0° and 2.7° ± 2.0°, respectively, and the angles at maximum flexion were 131.8° ± 13.0° and 130.8° ± 4.5°, respectively. There were statistically significant correlations between the EMS and radiographic measurements; the Bland-Altman plots indicated that the two methods were almost in agreement for both extension and flexion. CONCLUSIONS: This method of measuring ROM of the elbow joint using EMS showed high accuracy, reliability, and reproducibility. The current results demonstrated the possibility of using the electromagnetic system to provide an accurate evaluation of the elbow joint in clinical settings.

  Jan. 2022, Journal of orthopaedic surgery and research, 17(1) (1), 60 - 60, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle.

  Issei Shinohara, Takeshi Kataoka, Yutaka Mifune, Atsuyuki Inui, Ryosuke Sakata, Hanako Nishimoto, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Tatsuo Kato, Takahiro Furukawa, Takehiko Matsushita, Ryosuke Kuroda

  Tendon rupture and nerve injury cause fatty infiltration of the skeletal muscle, and the adipokines secreted from the infiltrated adipocytes are known to contribute to chronic inflammation. Therefore, in this study, we evaluated the effects of the adipokines on chronic inflammation using a rat sciatic nerve-crushed injury model. In vitro and in vivo experiments showed that the expression of adiponectin was decreased (0.3-fold) and the expression of Il6 (~ 3.8-fold) and Tnf (~ 6.2-fold) was increased in the nerve-crushed group compared to that in the control group. It was also observed that the administration of an adiponectin receptor agonist decreased the levels of Il6 (0.38-fold) and Tnf (0.28-fold) and improved cellular viability (~ 1.9-fold) in vitro. Additionally, in the fatty infiltrated skeletal muscle, low adiponectin levels were found to be associated with chronic inflammation. Therefore, the local administration of adiponectin receptor agonists would prevent chronic inflammation.

  Jan. 2022, Scientific reports, 12(1) (1), 1557 - 1557, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Motion Analysis of Triangular Fibrocartilage Complex by Using Ultrasonography Images: Preliminary Analysis.

  Issei Shinohara, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Tatsuo Kato, Takahiro Furukawa, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  The triangular fibrocartilage complex (TFCC) is a significant stabilizer of the distal radioulnar joint. Diagnosing TFCC injury is currently difficult, but ultrasonography (US) has emerged as a low-cost, minimally invasive diagnostic tool. We aimed to quantitatively analyze TFCC by performing motion analysis by using US. Twelve healthy volunteers, comprising 24 wrists (control group), and 15 patients with TFCC Palmer type 1B injuries (injury group) participated. The US transducer was positioned between the ulnar styloid process and triquetrum and was tilted ulnarly 30° from the vertical line. The wrist was then actively moved from 10° of radial deviation to 20° of ulnar deviation in a 60-rounds-per-minute rhythm that was paced by a metronome. The articular disc displacement velocity magnitude was analyzed by using particle image velocimetry fluid measurement software. The mean area of the articular discs was larger on ulnar deviation in the control group. The mean articular disc area on radial deviation was larger in the injury group. The average articular disc velocity magnitude for the injury group was significantly higher than that for the control group. The results suggest that patients with TFCC injury lose articular disc cushioning and static stability, and subsequent abnormal motion can be analyzed by using US.

  Jan. 2022, Sensors (Basel, Switzerland), 22(1) (1), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Immediate Effects of Myofascial Release for Peripatellar Soft Tissue on the Knee Function of Patients with Knee Osteoarthritis: A Randomized Controlled Trial

  Yuichi ISAJI, Atsuyuki INUI, Kenta HIROSE, Takumi YAMADA

  Society of Physical Therapy Science, 2022, Rigakuryoho Kagaku, 37(2) (2), 165 - 169

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Assessment of posterior shoulder muscle stiffness related to posterior shoulder tightness in college baseball players using shear wave elastography

  美舩 泰, 篠原 一生, 加藤 達雄, 古川 隆浩, 乾 淳幸, 黒田 良祐

  南江堂, Nov. 2021, 整形外科, 72(12) (12), 1315 - 1318


• Combined therapy of platelet-rich plasma and basic fibroblast growth factor using gelatin-hydrogel sheet for rotator cuff healing in rat models.

  Takeshi Kataoka, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Shintaro Mukohara, Takehiko Matsushita, Takahiro Niikura, Yasuhiko Tabata, Ryosuke Kuroda

  INTRODUCTION: Excellent outcomes of arthroscopic rotator cuff repair for small and medium tears have been recently reported. However, re-tears after surgery have been a common complication after surgical repair of large and massive rotator cuff tears and often occur in early postoperative phase. It was previously reported that basic fibroblast growth factor and platelet-rich plasma enhanced rotator cuff tear healing. We hypothesized that this combined therapy could enhance rotator cuff healing after rotator cuff repair in a rat model. This study aimed to evaluate the efficacy of combined therapy of platelet-rich plasma and basic fibroblast growth factor with gelatin-hydrogel sheet. METHODS: To create a rotator cuff defect, the infraspinatus tendon of Sprague Dawley rat was resected from the greater tuberosity. The infraspinatus tendons were repaired and covered with gelatin-hydrogel sheet impregnated with PBS (control group), basic fibroblast growth factor (bFGF group), platelet-rich plasma (PRP group), or both basic fibroblast growth factor and platelet-rich plasma (combined group). Histological examinations were conducted using hematoxylin and eosin, safranin O, and immunofluorescence staining, such as Isolectin B4, type II collagen at 2 weeks postoperatively. For mechanical analysis, ultimate failure load of the tendon-humeral head complex was evaluated at 6 weeks postoperatively. RESULTS: In the hematoxylin and eosin staining, the tendon maturing score of the combined group was higher than that of the control group at postoperative 2 weeks. In the safranin O staining, stronger proteoglycan staining was observed in the combined group compared with the other groups at postoperative 2 weeks. Vascular staining with isolectin B4 in 3 treatment groups was significantly higher than that in the control group. Type II collagen expression in the combined group was significantly higher than those in the other groups. The ultimate failure load of the combined group was significantly higher than that of the control group. CONCLUSION: Combined therapy of basic fibroblast growth factor and platelet-rich plasma promoted angiogenesis, tendon maturing and fibrocartilage regeneration at the enthesis, which could enhance the mechanical strength. It was suggested that combined basic fibroblast growth factor and platelet-rich plasma might enhance both tendon and bone-tendon junction healing, and basic fibroblast growth factor and platelet-rich plasma might be synergistic.

  Oct. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 605 - 605, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Throwing elbow stress measured by wearable sensor and ultrasound evaluation

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 黒田 良祐

  金原出版, Oct. 2021, 整形･災害外科, 64(11) (11), 1407 - 1413


• A case of PLRI of the elbow with lateral collateral ligament reconstruction by triceps fascia

  NAKATANI Hanaha

  THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, Sep. 2021, The Central Japan Journal of Orthopaedic Surgery & Traumatology, 64(5) (5), 691 - 692, Japanese


• 機械学習モデルによる既存椎体骨折の有無の診断の試み

  乾 淳幸, 西本 華子, 美舩 泰, 新倉 隆宏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2021, 日本骨粗鬆症学会雑誌, 7(Suppl.1) (Suppl.1), 268 - 268, Japanese


• コロナ禍における骨粗鬆症患者の骨密度の推移

  西本 華子, 乾 淳幸, 美舩 泰, 丸野 文雅, 金谷 貴子, 新倉 隆宏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2021, 日本骨粗鬆症学会雑誌, 7(Suppl.1) (Suppl.1), 348 - 348, Japanese


• Sequential Changes in Posterior Shoulder Muscle Elasticity After Throwing as Assessed via Ultrasound Shear Wave Elastography.

  Kohei Yamaura, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takeshi Kataoka, Takashi Kurosawa, Shintaro Mukohara, Takahiro Niikura, Takeshi Kokubu, Ryosuke Kuroda

  Background: Improvements in ultrasound diagnostic equipment and techniques can enable muscle stiffness to be measured quantitatively as muscle elasticity using ultrasound shear wave elastography (USWE), where high muscle elasticity values represent muscle stiffness. Purpose: To use USWE to analyze the sequential changes in muscle elasticity in the posterior shoulder before and after pitching. Study Design: Descriptive laboratory study. Methods: The authors evaluated 14 baseball players who had played in high school or college at an intermediate level. The elasticity of the supraspinatus, infraspinatus (ISP), middle trapezius, lower trapezius (LT), rhomboideus, and serratus anterior muscles of the throwing shoulder was measured using USWE at 3 time points: before, immediately after, and 24 hours after a throwing session of 100 pitches. The authors analyzed the sequential changes in the mean elasticity values of the respective muscles at the 3 time points. Results: The mean elasticity values before, immediately after, and 24 hours after throwing were as follows: supraspinatus: 32.9, 53.4, 43.8 kPa; ISP: 22.7, 44.8, 43.7 kPa; middle trapezius: 45.1, 70.3, 59.9 kPa; LT: 32.8, 45.5, 46.5 kPa; rhomboideus: 29.1, 47.5, 38.8 kPa; and serratus anterior: 19.2, 36.9, 26.5 kPa, respectively. The mean elasticity values for all tested muscles were significantly higher immediately after throwing compared with before throwing (P ≤ .0086 for all), and elasticity values in the ISP and LT remained significantly higher 24 hours after throwing compared with before throwing (P ≤ .019 for both). Conclusion: The study results indicated that pitching significantly increased ISP and LT muscle elasticity even after 24 hours.

  Aug. 2021, Orthopaedic journal of sports medicine, 9(8) (8), 23259671211021362 - 23259671211021362, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A new quantitative evaluation system for distal radioulnar joint instability using a three-dimensional electromagnetic sensor.

  Shintaro Mukohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Tomoya Yoshikawa, Issei Shinohara, Yuichi Hoshino, Kouki Nagamune, Ryosuke Kuroda

  BACKGROUND: The accurate assessment of distal radioulnar joint (DRUJ) instability is still challenging as there is no established objective evaluation method. This study aimed to develop a noninvasive measurement method using a three-dimensional electromagnetic sensor system (EMS) to quantitatively assess and characterize the normal DRUJ movement in healthy volunteers. METHODS: The DRUJ movement was mimicked using both a block model and saw bone. Movement of the models was measured by EMS, and the accuracy and reproducibility of the measurements were assessed. In vivo measurement was performed in a sitting position with the elbow flexed and the forearm pronated. One sensor each was attached to the distal radial shaft and the ulnar head. The examiners fixed the distal radius and the carpal bones, moved the ulnar head from the dorsal to the volar side and measured the dorsovolar translation. The volar translation was measured by EMS and ultrasonography, and the correlation coefficient was calculated. The dorsovolar translation was evaluated in 14 healthy volunteers (7 men and 7 women) by three hand surgeons. The intraclass and inter-rater correlation coefficients (ICCs), the differences between the dominant and non-dominant sides and between men and women were assessed. RESULTS: The accuracy and reproducibility assessment results of the EMS showed high accuracy and reproducibility. In the comparison between EMS and ultrasonography, the correlation coefficient was 0.920 (p = 0.16 × 10-3). The ICC (1,5) for the intra-rater reliability was 0.856, and the ICC (2,5) for inter-rater reliability was 0.868. The mean ulnar head translation and difference between dominant and non-dominant sides were 6.00 ± 1.16 mm (mean ± SD) and - 0.12 ± 0.40 mm, respectively. There were no significant differences between any of the parameters. CONCLUSIONS: A new measurement method using EMS could evaluate DRUJ movement with high accuracy, reproducibility, and intra- and inter-rater reliability. In healthy volunteers, the dorsovolar ulnar head translation was 6.00 mm. The difference between the dominant and non-dominant sides was < 1.0 mm with no significant difference. EMS provided an objective, non-invasive, real-time assessment of dynamic changes in the DRUJ. These findings could be useful in the treatment of patients with DRUJ instability.

  Jul. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 452 - 452, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• In vitro and in vivo tenocyte-protective effectiveness of dehydroepiandrosterone against high glucose-induced oxidative stress.

  Shintaro Mukohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Tomoya Yoshikawa, Ryosuke Kuroda

  BACKGROUND: Dehydroepiandrosterone (DHEA), an adrenal steroid, has a protective role against diabetes. This study aimed to investigate the in vitro and in vivo protective effects of DHEA against high glucose-induced oxidative stress in tenocytes and tendons. METHODS: Tenocytes from normal Sprague-Dawley rats were cultured in low-glucose (LG) or high-glucose (HG) medium with or without DHEA. The experimental groups were: control group (LG without DHEA), LG with DHEA, HG without DHEA, and HG with DHEA. Reactive oxygen species (ROS) production, apoptosis, and messenger RNA (mRNA) expression of NADPH oxidase (NOX) 1 and 4, and interleukin-6 (IL-6) were determined. Further, diabetic rats were divided into a control group and a DHEA-injected group (DHEA group). NOX1 and NOX4 protein expression and mRNA expression of NOX1, NOX4, IL-6, matrix metalloproteinase (MMP)-2, tissue inhibitors of matrix metalloproteinase (TIMP)-2, and type I and III collagens in the Achilles tendon were determined. RESULTS: In rat tenocytes, DHEA decreased the expression of NOX1 and IL-6, ROS accumulation, and apoptotic cells. In the diabetic rat Achilles tendon, NOX1 protein expression and mRNA expression of NOX1, IL-6, MMP-2, TIMP-2, and type III collagen were significantly lower while type I collagen expression was significantly higher in the DHEA group than in the control group. CONCLUSIONS: DHEA showed antioxidant and anti-inflammatory effects both in vitro and in vivo. Moreover, DHEA improved tendon matrix synthesis and turnover, which are affected by hyperglycemic conditions. DHEA is a potential preventive drug for diabetic tendinopathy.

  Jun. 2021, BMC musculoskeletal disorders, 22(1) (1), 519 - 519, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effects of trochlear fragmentation on functional outcome in coronal shear fractures: a retrospective comparative study.

  Shintaro Mukohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Tomoya Yoshikawa, Takahiro Waki, Tsukasa Kuroda, Takahiro Niikura, Ryosuke Kuroda

  Background: Coronal shear fractures of the distal humerus are rare injuries, and fragmentation of the capitellum and trochlea with posterior comminution is challenging for surgeons. We retrospectively evaluated the functional outcomes of patients with coronal shear fractures managed with open reduction and internal fixation, focusing on the number of trochlea fragments in Dubberley type 3B fractures. Materials and methods: The functional outcomes of 25 patients, including 8 patients with type 3B fractures, with a mean age (and standard deviation) of 57 ± 20 years, were evaluated at a mean follow-up duration of 15 ± 9 months. Type 3B fractures were classified into two groups: those with two trochlea fragments or less group (group A) and those with three or more fragments (group B). Patient outcomes were assessed with clinical and radiographic examination, range of motion, and the Mayo Elbow Performance scale (MEPS). Results: Two patients with type 3B in group B experienced nonunion, and two patients with type 3B in group A and 1 patient with type 1B demonstrated avascular necrosis on radiographs. The average MEPS score was 96.3 points (range, 70-100), with 18 excellent, 5 good, and 1 fair results. The average range of motion was 10 ± 8 to 130 ± 12. The MEPS score worsened as Dubberley classification progressed from type 1 to type 3 (98.3 vs. 96.7 vs. 88, P = .014, respectively) and subtypes A to B (97.9 vs. 90, P = .014, respectively). In comparing groups A and B, the MEPS score was significantly worse in group B (93.8 vs. 76.3, P = .006). Conclusion: Our open reduction and internal fixation results were largely good, although functional outcomes were diminished as Dubberley classification progressed from type 1 to type 3 and subtype A to B. Type 3B fractures with three trochlea fragments or more in the elderly were the most difficult to treat with open reduction and internal fixation and possibly 1-term total elbow arthroplasty.

  May 2021, JSES international, 5(3) (3), 571 - 577, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Floating forearm associated with terrible triad injury and Essex-Lopresti injury: a case report and literature review.

  Issei Shinohara, Shunsuke Takahara, Atsuo Uefuji, Atsuyuki Inui, Yutaka Mifune, Katsuhito Ichimura, Hirotaka Nishihara, Kenta Kishimoto, Kenji Aoki, Hiroyuki Takayama, Natsuko Nakagawa, Toshihiko Harada

  Mar. 2021, JSES international, 5(2) (2), 320 - 327, English, International magazine


• Isolated Musculocutaneous Nerve Injury in a Professional Baseball Player: A Case Report.

  Takeshi Kataoka, Takeshi Kokubu, Yutaka Mifune, Atsuyuki Inui, Tetsuya Yamazaki, Ryosuke Kuroda

  Introduction: Musculocutaneous nerve lesion in a throwing athlete is a rare condition. We report the case of a professional baseball pitcher with an isolated musculocutaneous nerve lesion that occurred during a pitching motion. Case Presentation: The patient had radiating pain in the upper arm and weakness of elbow flexion. Physical examination revealed flaccid paralysis of the biceps brachii muscle and paresthesia in the right lateral forearm. Musculocutaneous nerve injury was suspected. Because some signs of recovery were observed within a few days, the patient received non-operative management. Nerve conduction studies at 2 weeks after the injury showed low-amplitude compound muscle action potential of the right biceps brachii muscle by stimulation of the musculocutaneous nerve. Needle electromyography showed markedly reduced motor unit potential recruitment in the biceps brachii muscle. He was diagnosed as having isolated musculocutaneous nerve injury. At 2 months after the injury, the muscle contraction and strength of the biceps brachii muscle improved. At 7 months after the injury, muscle weakness was fully recovered. His pitching ability returned to that of a competitive player. Conclusion: Because the neuroparalysis was incomplete and began to recover within a few days, we considered the pathology of this injury to be incomplete axonotmesis, which was successfully treated conservatively.

  Mar. 2021, Journal of orthopaedic case reports, 11(3) (3), 113 - 116, English, International magazine


• Conventional computed tomography software can be used for accurate pre-operative templating in bipolar hip arthroplasty: A preliminary report.

  Nobuaki Chinzei, Mitsuaki Noda, Hiroshi Nashiki, Takehiko Matsushita, Atsuyuki Inui, Shinya Hayashi

  Background: The aim of this study was to investigate the use of pre-operative templating for bipolar hip arthroplasty (BHA) for displaced femoral neck fracture using multiplanar reconstruction (MPR) of computed tomography (CT) images. Methods: Nineteen patients who underwent BHA were enrolled in this study. For pre- and post-operative evaluation, a CT scan was performed from the pelvis to the knee joints. MPR of the CT image was done using software to measure the femoral head cup diameter, offset, stem size, length of the modular neck, distance from the neck osteotomy, and femoral anteversion. We compared these parameters pre- and post-operatively. Results: Both the femoral head cup diameter and length of the modular neck were found to be significantly different between pre- and post-operative measurements, although the differences were minor. Other parameters, including the femoral offset, were not significantly different between the pre- and post-operative measurements. The size of the femoral stem, cup diameter, and length of the modular neck were consistent with the planned size and accurate (within ±1 size) in more than 84% cases. Conclusion: Our pre-operative templating approach for BHA using MPR of CT has potential clinical utility as a complementary tool for pre-operative planning using three-dimensional templating software. Moreover, this technique could be feasible in most hospitals without additional expenditure.

  Feb. 2021, Journal of clinical orthopaedics and trauma, 13, 1 - 8, English, International magazine

  Scientific journal


• Closed Compression Nailing Using a New-Generation Intramedullary Nail without Autologous Bone Grafting for Humeral Shaft Nonunion.

  Genta Fukumoto, Tomoaki Fukui, Keisuke Oe, Atsuyuki Inui, Yutaka Mifune, Ryosuke Kuroda, Takahiro Niikura

  Introduction: Although the recommended treatment for humeral shaft nonunion is compression plating with autologous bone grafting, we treated a case of humeral shaft nonunion with an intramedullary nail (IMN) without bone grafting. Presentation of Case. Osteosynthesis with IMN was performed on a 24-year-old man with a humeral shaft fracture at another hospital. However, bony union was not obtained 1 year after the first surgery, and he was referred to our institution. We treated the nonunion with exchange nailing without autologous bone grafting using compression function of the nail, leading to bony union at 7 months postoperatively. At the final follow-up 2 years and 4 months postoperatively, the patient had full range of motion in the left shoulder and elbow joints. Discussion. Compression plating with autologous bone grafting is reported to be the gold standard for the treatment of humeral shaft nonunion. IMN is advantageous for minimal invasion; however, the conventional type of IMN cannot apply compression force between fragments and does not have sufficient stability against rotational force. In this case, we used an IMN that could apply compression between the fragments and which had rotational stability via many screws. We did not perform bone grafting because the current nonunion was adjudged to be biologically active, and we achieved good functional results. Conclusion: We treated humeral shaft nonunion using IMN with compression, but without bone grafting, leading to successful clinical outcomes. This strategy might be an appropriate choice for the treatment of humeral shaft nonunion with biological activity.

  2021, Case reports in orthopedics, 2021, 5548729 - 5548729, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Anterior transolecranon fracture dislocation with an associated avulsion fracture of coronoid process of ulna in a child: a case report.

  Kohei Yamaura, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Takeshi Kataoka, Takashi Kurosawa, Shintaro Mukohara, Tomoya Yoshikawa, Takahiro Niikura, Takeshi Kokubu, Ryosuke Kuroda

  Jan. 2021, JSES international, 5(1) (1), 9 - 12, English, International magazine


• Relationship between Glenohumeral Internal Rotation Deficit and Shoulder Conditions in Professional Baseball Pitchers.

  Kohei Yamaura, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Shintaro Mukohara, Tomoya Yoshikawa, Yuichi Hoshino, Takahiro Niikura, Takeshi Kokubu, Ryosuke Kuroda

  BACKGROUND: Previous studies have reported that glenohumeral internal rotation deficit (GIRD) may increase the risk of throwing shoulder injuries. The purpose of this study was to analyze the conditions of throwing shoulder in professional baseball pitchers with GIRD by comparing with those in pitchers without GIRD. METHODS: In total, 26 male professional baseball pitchers participated in this study. We evaluated the passive range of motion (ROM) and isometric muscle strength at internal rotation (IR) and external rotation (ER) at 90° abduction, as well as the muscle thickness of the supraspinatus (SSP) and infraspinatus (ISP) by ultrasound. The pitchers were divided into two groups as follows: GIRD group who exhibit a loss of 20° or more in the throwing shoulder IR2, and the remaining participants who did not, in the non-GIRD group. RESULTS: In the GIRD group, the total range of motion (TRM) deficit (throwing - non-throwing) (p < 0.001), the muscle thickness ratio (throwing:non-throwing) of the SSP and ISP (p = 0.017 and p = 0.014, respectively), and the muscle strength ratio (throwing:non-throwing) of ER (p = 0.028) were significantly lower than those of the non-GIRD group. In contrast, the muscle strength ratio (throwing:non-throwing) of the IR (p = 0.0064) in the GIRD group was significantly higher than that in the non-GIRD group. CONCLUSIONS: We showed that GIRD had significant correlations with several conditions, such as atrophy of the SSP and ISP, weakness of ER strength, enhancement of IR strength, limitation of the TRM, and throwing side, all of which could be important factors for throwing shoulder injuries. LEVEL OF EVIDENCE: Level III; Cross-Sectional Case-Control Design; Prognosis Study.

  Dec. 2020, Journal of shoulder and elbow surgery, 30(9) (9), 2073 - 2081, English, International magazine

  Scientific journal


• Osteochondritis Dissecans of the Humeral Trochlea Treated with Mosaic-type Osteochondral Autologous Transplantation.

  Yoshifumi Harada, Atsuyuki Inui, Takeshi Kokubu, Yutaka Mifune, Hanako Nishimoto, Ryosuke Kuroda

  Introduction: The majority of osteochondritis dissecans (OCD) of the elbow occurs in the humeral capitellum in adolescence while OCD in the humeral trochlea is relatively rare. We report a rare case of OCD in the humeral trochlea, which underwent mosaic-type osteochondral autologous transplantation. Case Report: A 24-year-old man, who was a gymnastic athlete, complained of severe right elbow pain for 9 years. Image findings revealed a trochlear osteochondral defect with intra-articular loose body. Due to the large defect and duration of the disease, autologous osteochondral transplantation form femoral condyle was performed. Two years after surgery, the range of elbow motion was 0° in extension and 120° in flexion. He had no pain on his elbow. Conclusion: OCD in the humeral trochlea was treated with mosaic-type osteochondral autologous transplantation form femoral condyle. Despite the large trochlear defect, osteochondral transplantation yielded a satisfactory result and this treatment might be an option for treatment of trochlear OCD.

  Dec. 2020, Journal of orthopaedic case reports, 10(9) (9), 106 - 108, English, International magazine


• Reconstruction of Carpal Bone Loss of Septic Wrist Arthritis Using Induced Membrane Technique.

  Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Takahiro Niikura, Ryosuke Kuroda

  The induced membrane technique has been widely used for the reconstruction of the segmental bone defect. The technique requires two-stage surgery. The first surgery is debridement of the affected bone and replacement of the defect by cement spacer. The spacer is removed at the second surgery, and the defect is filled with cancellous bone. The use of the technique for septic wrist arthritis treatment has not been reported. We report two cases of septic wrist arthritis treated by the induced membrane technique. Radical debridement including the carpal bones was performed as a first surgery. The cement spacer was placed into the bone defect after first surgery; then cancellous bone was transplanted into the induced membrane several weeks later. External fixator or plate fixation was performed simultaneously. Bone formation was observed in both cases at several months after the reconstruction surgery. There was no pain or recurrence of infection in both cases. We consider this technique is a possible method for reconstruction, especially in a difficult case.

  Oct. 2020, Journal of hand and microsurgery, 12(Suppl 1) (Suppl 1), S54-S57, English, International magazine


• Muscle Strains in the Lower Extremity of Japanese Professional Baseball Players.

  Takeshi Kokubu, Yutaka Mifune, Noriyuki Kanzaki, Yuichi Hoshino, Kenichiro Kakutani, Atsuyuki Inui, Shingo Hashimoto, Ryosuke Kuroda

  Background: Predicting when athletes can return to play after muscle strains is not always simple because of difficulties in evaluating the severity of such injuries. Purpose/Hypothesis: The purpose of this study was to evaluate the use of magnetic resonance imaging (MRI) to classify lower extremity muscle strains in Japanese professional baseball players. The hypothesis was that MRI grading can be used to diagnose the severity of muscle strains in the lower extremity and predict return to play in athletes. Study Design: Case series; Level of evidence, 4. Methods: A total of 55 muscle strains occurred in the lower extremity of players on a professional baseball team between the 2006 and 2015 seasons; all players had undergone MRI examination. Age, player position, location of injury, cause of injury, and duration until return to play (in days) were extracted from the medical records. MRI scans were classified using the following system: grade 0, no abnormal findings; grade 1a, T2-weighted high intensity only between muscles; grade 1b, T2-weighted high intensity between muscles and in muscle belly; grade 2, injury of musculotendinous junction; and grade 3, rupture of tendon insertion. Results: The sites of injuries were distributed as follows: hamstrings (n = 33), quadriceps (n = 6), hip adductors (n = 6), and calves (n = 10). MRI findings revealed 9 muscle strains (16%), 19 grade 1a (34%), 19 grade 1b (34%), and 8 grade 2 muscle strains (16%). The length of time until return to training and competition, respectively, was 15 and 26 days for grade 1a injuries, 19 and 36 days for grade 1b injuries, and 55 and 69 days for grade 2 injuries. Conclusion: Players with grade 1 injuries took 4 to 5 weeks to return to play, whereas players with grade 2 injuries took 10 weeks to return. MRI can be useful for diagnosing lower extremity muscle strains and predicting the time to return to play.

  Oct. 2020, Orthopaedic journal of sports medicine, 8(10) (10), 2325967120956569 - 2325967120956569, English, International magazine

  Scientific journal


• Bilateral Collateral Ligament Reconstruction for Chronic Elbow Dislocation.

  Takeshi Kataoka, Takeshi Kokubu, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Shintaro Mukohara, Ryosuke Kuroda

  We report the case of a 37-year-old male with autism spectrum disorder who was hospitalized for chronic elbow dislocation. He had suffered a posterior elbow dislocation 5 months ago. His elbow dislocation was easily reduced, but the reduction position could not be maintained. Severe varus and valgus instabilities were observed in his right elbow. He was diagnosed with chronic elbow dislocation due to bilateral collateral ligament dysfunction and was surgically treated. Bilateral ligament reconstruction using the bilateral palmaris longus (PL) tendon combined with a temporary ulnohumeral joint fixation was performed. Cast immobilization was applied for 6 weeks. One year after surgery, his range of motion was -15° in extension, 140° in flexion, 80° in pronation, and 90° in supination. He did not face any problems in daily activities.

  Sep. 2020, The Kobe journal of medical sciences, 66(2) (2), E71-E74, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 糖尿病性腱障害モデルに対するアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1680 - S1680, Japanese


• 老化制御因子NMN(nicotinamide mononucleotide)の腱炎に対する抗炎症・酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1746 - S1746, Japanese


• 高血糖誘導酸化ストレスを与えた腱細胞に対するDHEAの効果

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1747 - S1747, Japanese


• 高血糖負荷による酸化ストレスを与えた腱細胞に対するquercetinの抗酸化作用の検討

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1758 - S1758, Japanese


• ウェアラブルセンサで測定した投球肘ストレスと超音波剪断波エラストグラフィで評価した前腕回内屈筋の組織弾性との相関

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1899 - S1899, Japanese


• 三次元電磁気センサを使用した遠位橈尺関節不安定性の定量評価法

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 吉川 智也, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1903 - S1903, Japanese


• ラット腱板修復モデルにおけるティラピア由来うろこコラーゲンの有効性の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1927 - S1927, Japanese


• 骨粗鬆症外来受診患者にたいする機械学習による骨密度予測

  乾 淳幸, 西本 華子, 美舩 泰, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2020, 日本骨粗鬆症学会雑誌, 6(Suppl.1) (Suppl.1), 244 - 244, Japanese


• Trabecular Bone Score(TBS)は治療の効果判定に有用か

  西本 華子, 乾 淳幸, 美舩 泰, 新倉 隆宏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2020, 日本骨粗鬆症学会雑誌, 6(Suppl.1) (Suppl.1), 254 - 254, Japanese


• 骨粗鬆症外来における機械学習を用いた骨密度予測

  乾 淳幸, 西本 華子, 美舩 泰, 新倉 隆宏, 黒田 良祐

  骨粗鬆症外来を受診した女性1781例(平均年齢73.1歳)を対象に、年齢、BMI、骨粗鬆症スクリーニング採血データの25項目からYAM値70%以上であるか否かを予測する2値分類を試みた。まず各特徴量に対しカーネル密度推定を行い、YAM値が70%以上の群と70%未満の群の分布を可視化した。次に機械学習用のソフトウェア(Prediction One)を使用し、勾配ブースティング決定木を用いて学習を行った。患者データの精度の検証を行い、YAM値が70%以上であればYes(A群)、70%未満であればNo(B群)とした。その結果、機械学習によるYAM値70%以上の骨粗鬆症患者の予測精度は80%以上と高かった。A群として判定される特徴量は重要なものから順に若年齢、高BMI、低BUN、高血小板数、高Hb値であった。B群として判定される特徴量は低BMI、高年齢、低Hb値、血清Alb低値、PINP高値で、これらのデータが骨粗鬆症と判断される因子と考えられた。

  (一社)中部日本整形外科災害外科学会, Jul. 2020, 中部日本整形外科災害外科学会雑誌, 63(4) (4), 631 - 632, Japanese


• 小脳性運動失調に対しRehabwareを用いてVirtual Reality課題を実施した一症例

  大川 直子, 乾 淳幸, 村中 由香, 伊藤 智永子, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 1 - 8, Japanese


• プロ野球投手の肩関節コンディションと股関節可動域スコアの関係

  美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 3 - 1, Japanese


• プロ野球投手におけるGlenohumeral internal rotation deficit(GIRD)に関連する因子の検討

  美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 3 - 2, Japanese


• Leap Motionを使用した仮想空間上での母指運動の評価

  乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 4 - 3, Japanese


• STT(scaphotrapezial trapezoidal)関節症に対してMini-TightRopeを用いたSuspensionplastyを行った2例

  美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 36(6) (6), 941 - 944, Japanese


• 三次元電磁気センサを使用した遠位橈尺関節不安定性の定量評価法の開発

  向原 伸太郎, 乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 吉川 智也, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O2 - 2, Japanese


• 粒子画像流速測定法による正中神経のエコー画像解析

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O3 - 4, Japanese


• 老化制御因子NMN(Nicotinamide Mononucleotide)の腱炎に対する抗炎症・酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O9 - 2, Japanese


• 手根管症候群の超音波画像に対するディープラーニング

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O62 - 1, Japanese


• Treatment of Locking of the Metacarpophalangeal Joint of the Thumb.

  Yoshifumi Harada, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Takeshi Kokubu, Fujioka Hiroyuki, Ryosuke Kuroda

  Locking of the thumb metacarpophalangeal joint is a relatively rare condition. We report successful treatment in 11 cases of locking of the thumb. Ten patients were diagnosed at an average of 3.2 days (range: 0-21 days) from the injury onset, whereas one patient was diagnosed at 4 months from the injury. Seven of 11 cases underwent successful manual reduction, whereas the other four cases required surgical treatment. Among the surgically treated cases, all cases had a sharp prominent of the radial condyle of the metacarpal head. Therefore, this case series showed 1 chronic case and 4 of 10 cases with a nonround shape of metacarpal heads requiring open reduction.

  Apr. 2020, Journal of hand and microsurgery, 12(1) (1), 62 - 66, English, International magazine

  Scientific journal


• Assessment of posterior shoulder muscle stiffness related to posterior shoulder tightness in college baseball players using shear wave elastography.

  Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takeshi Kataoka, Takashi Kurosawa, Kohei Yamaura, Shintaro Mukohara, Takahiro Niikura, Takeshi Kokubu, Toshihiro Akisue, Ryosuke Kuroda

  BACKGROUND: Limitations of shoulder range of motion (ROM) have been reported to be at high risk for shoulder disorders in baseball players. In this study, we assessed posterior shoulder muscle stiffness using shear wave elastography in baseball players with and without posterior shoulder tightness. MATERIALS AND METHODS: In total, 21 college baseball players volunteered to participate in this study. Passive ROMs for shoulder abduction and horizontal adduction were measured using a goniometer. Subsequently, we divided all participants into 2 groups based on the differences between bilateral shoulder ROMs: STIFF+ and STIFF- groups. Thickness and elasticity of the posterior and inferior shoulder muscles were assessed using ultrasound. RESULTS: Shoulder abduction ROM on the throwing side was 114.5° ± 5.3° and 131.3° ± 5.7° in the STIFF+ and STIFF- groups, respectively, which was significantly different between the 2 groups (P = .023). Horizontal adduction ROM on the throwing side was 96.6° ± 4.9° and 110.9° ± 4.8° in the STIFF+ and STIFF- groups, respectively, which was also significantly different between the 2 groups (P = .014). The elasticity of infraspinatus and lower trapezius in the STIFF+ group was significantly greater than that in the STIFF- group (P = .018 and .033, respectively). DISCUSSION: In this study, we found that the elasticity of infraspinatus and lower trapezius in stiff shoulders was significantly greater than that in nonstiff shoulders, which indicated that the infraspinatus and lower trapezius could be the key muscles in posterior shoulder tightness.

  Mar. 2020, Journal of shoulder and elbow surgery, 29(3) (3), 571 - 577, English, International magazine

  [Refereed]

  Scientific journal


• Does the duration to bipolar hip arthroplasty for femoral neck fracture influence on postoperative muscular strength?

  Nobuaki Chinzei, Mitsuaki Noda, Takehiko Matsushita, Atsuyuki Inui, Shin Osawa, Kenjiro Okimura, Masayasu Takahashi, Yasuhiro Saegusa

  BACKGROUND: The primary purpose of this study was to compare the postoperative muscular strength and functional performance between early versus late bipolar hip arthroplasty (BHA) intervention for femoral neck fracture classified by the duration from the onset to surgery. METHODS: Twenty-one patients who could walk at 12 months or more after BHA were enrolled into this study. We examined the muscular strength of hip flexion, extension, abduction, and knee extension of these patients. Time of one-leg standing, timed up and go test, pain grade by visual analog scale, and Barthel index were also evaluated as functional indices. We classified these patients into two groups by the duration from the onset to surgery, namely: within 3 days until BHA (early OP) and more than 4 days (late OP) to compare these indices at the latest follow-up. RESULTS: The mean days until operation were 2.3 days in the early-OP group and 5.9 days in the late-OP group, showing a significant difference between the two groups. Muscular strength and other functional indices were also found to have no significant differences between these two groups. CONCLUSION: Our study suggests that the delay to operate might not severely compromise the muscular strength around the hip joint for least 1.5 years among ambulatory patients.

  Feb. 2020, European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 30(2) (2), 251 - 256, English, International magazine

  Scientific journal


• Isolated Nerve Grafting for a Young Patient with a Complete Common Peroneal Nerve Palsy Following a Traumatic Knee Dislocation: A case report.

  Shintaro Mukohara, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Takeshi Kataoka, Takashi Kurosawa, Kohei Yamaura, Ryosuke Kuroda

  BACKGROUND: Common peroneal nerve (CPN) injury following a knee dislocation is a serious problem, and an optimal treatment is yet to be established. We report a case of complete CPN palsy following a knee dislocation treated with sural nerve grafting. CASE: A 19-year-old man suffered a knee injury during a hurdle race. Diagnosis in a previous hospital revealed a complex ligament injury with CPN palsy. Ten weeks following injury, he was admitted to our institution because of a lack of neurological improvement. Considering the grade 0 results obtained in the manual muscle test (MMT) of tibialis anterior (TA) and extensor hallucis longus (EHL), the patient was diagnosed with complete neurotmesis of CPN, and surgery was performed. Operative findings revealed CPN discontinuity and an extended nerve defect length of 15 cm; therefore, sural nerve grafting was performed to repair the CPN injury. One year postoperatively, a grade 1 result from MMT of TA and EHL indicated a gradual neurological recovery. Three years postoperatively, MMT of TA and EHL showed significant improvement to grade 4+ and grade 4, respectively, and he could walk and jog without a knee brace. DISCUSSION: Nerve graft length of >6 cm has shown limited success, and their efficacy for the treatment of CPN palsy following knee dislocations is controversial. However, young patients with complete CPN lesion are more likely to recover regardless of the length of nerve injury. Therefore, in such cases, nerve grafting can be considered as one of the treatments for complete CPN lesion following knee dislocations.

  Jan. 2020, The Kobe journal of medical sciences, 65(3) (3), E110-E113, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Optimal injection depth for collagenase clostridium histolyticum determined by ultrasonography in the treatment of dupuytren’s disease

  I. Nagura, T. Kanatani, Y. Harada, A. Inui, Y. Mifune, R. Kuroda, S. Lucchina

  Czech Medical Association J.E. Purkyne, 2020, Acta Chirurgiae Plasticae, 62(3-4) (3-4), 64 - 67, English

  Scientific journal


• Myofascial release on the patella alters the thickness of the fat pad and range of motion of knee osteoarthritis patients

  Yuichi Isaji, Atsuyuki Inui, Yutaka Sato, Kenta Hirose, Takumi Yamada

  Society of Physical Therapy Science (Rigaku Ryoho Kagakugakkai), 2020, Rigakuryoho Kagaku, 35(5) (5), 679 - 683, Japanese

  Scientific journal


• Evaluation of apocynin in vitro on high glucose-induced oxidative stress on tenocytes

  T. Kurosawa, Y. Mifune, A. Inui, H. Nishimoto, Y. Ueda, T. Kataoka, K. Yamaura, S. Mukohara, R. Kuroda

  British Editorial Society of Bone and Joint Surgery, 2020, Bone and Joint Research, 9(1) (1), 23 - 28, English

  Scientific journal


• 手術加療を行った真の神経原性胸郭出口症候群の3症例

  向原 伸太郎, 乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 吉川 智也, 関口 兼司, 黒田 良祐

  日本末梢神経学会, Dec. 2019, 末梢神経, 30(2) (2), 300 - 300, Japanese

  [Refereed]


• Minimally invasive plate osteosynthesis for humeral shaft nonunion: A report of two cases.

  Yoshihito Suda, Keisuke Oe, Tomoaki Fukui, Yutaka Mifune, Atsuyuki Inui, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Dec. 2019, Annals of medicine and surgery (2012), 48, 43 - 47, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Development of Measurement System for Radioulnar Instability by Using 3D Electromagnetic Sensor and Pressure Sensor

  Akito Nakano, Kouki Nagamune, Atsuyuki Inui, Shintaro Mukohara, Kohei Yamaura, Ryosuke Kuroda

  Institute of Electrical and Electronics Engineers Inc., Nov. 2019, 2019 IEEE International Conference on Electrical, Control and Instrumentation Engineering, ICECIE 2019 - Proceedings, English

  International conference proceedings


• Treatment of Nonunion of the Ulnar Styloid by Low-Intensity Pulsed Ultrasound in a Baseball Player.

  Toshikazu Tanaka, Atsuyuki Inui, Yutaka Mifune

  Oct. 2019, Journal of hand and microsurgery, 11(Suppl 1) (Suppl 1), S59-S60, English, International magazine

  Scientific journal


• Influence of advanced glycation end products on rotator cuff.

  Yutaka Mifune, Atsuyuki Inui, Tomoyuki Muto, Hanako Nishimoto, Takeshi Kataoka, Takashi Kurosawa, Kohei Yamaura, Shintaro Mukohara, Takahiro Niikura, Takeshi Kokubu, Ryosuke Kuroda

  BACKGROUND: Most rotator cuff tears are the result of age-related degenerative changes, but the mechanisms underlying these changes have not been reported. Recently, advanced glycation end products (AGEs) have been regarded as an important factor in senescence. Therefore, we hypothesized that AGEs would have detrimental effects on rotator cuff-derived cells. In this study, we investigated the influence of AGEs on rotator cuff-derived cells in vitro and ex vivo. METHODS: Rotator cuff-derived cells were obtained from human supraspinatus tendons. The cells were cultured in the following media: (1) regular medium with 500 μg/mL AGEs (High-AGEs), (2) regular medium with 100 μg/mL AGEs (Low-AGEs), and (3) regular medium alone (Control). Cell viability, secretion of vascular endothelial growth factor, and the expressions of hypoxia-inducible factor-1α, reactive oxygen species, and apoptosis were assessed after cultivation. An ex vivo tissue culture with AGEs was also performed to measure the tensile strength. RESULTS: Cell viability in the High-AGEs group was significantly suppressed relative to that in the Controls. The amount of vascular endothelial growth factor secretion was significantly greater in the High- and Low-AGEs groups than in the Controls. Immunofluorescence stain demonstrated enhancement of hypoxia-inducible factor-1α and reactive oxygen species expressions and cell apoptosis in the High- and Low-AGEs groups relative to that in the Controls. In ex vivo mechanical testing, tensile strength was significantly higher in the Control group than in the AGEs groups. DISCUSSION: These results indicated that AGEs caused age-related degenerative rotator cuff changes. The reduction of AGEs might prevent rotator cuff senescence-related degeneration.

  Aug. 2019, Journal of shoulder and elbow surgery, 28(8) (8), 1490 - 1496, English, International magazine

  [Refereed]

  Scientific journal


• 母指MP関節過伸展を伴う背側不安定症に対して掌側板修復術を施行した2例

  田中 悟, 乾 淳幸, 西本 華子, 美舩 泰, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Jul. 2019, 中部日本整形外科災害外科学会雑誌, 62(4) (4), 747 - 748, Japanese


• 上腕骨遠位coronal shear fractureの治療成績

  向原 伸太郎, 乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 黒田 司, 脇 貴洋, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S201 - S201, Japanese


• ラット腱板修復術モデルに対するbFGFおよびPRP同時投与の有効性の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 酒井 良忠, 秋末 敏宏, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 2 - 2, Japanese

  [Refereed]


• Molecular changes to tendons after collagenase-induced acute tendon injury in a senescence-accelerated mouse model.

  Yasuhiro Ueda, Atsuyuki Inui, Yutaka Mifune, Fumiaki Takase, Takeshi Kataoka, Takashi Kurosawa, Kohei Yamaura, Takeshi Kokubu, Ryosuke Kuroda

  BACKGROUND: Aging impairs tendon healing and is a potential risk factor for chronic tendinitis. During normal aging, tendons undergo structural and biomechanical degenerative changes, accompanied by a reduction in the number of tenocytes and changes to their properties. However, molecular changes in aged tendons under inflammatory conditions are not well understood. The present study analyzed the molecular changes in collagenase induced acute tendon injury using a senescence-accelerated mouse (SAM) model. METHODS: SAMP6 mice were used as an aging animal model and SAMR1 mice were used as a control to represent a senescence-resistant inbred strain. All the mice used in the study were 40 weeks old. Collagenase I from Clostridium histolyticum (20 μL) was injected percutaneously to the tendon-bone junction of the Achilles tendon. Two weeks after treatment, the Achilles tendons were harvested and stained using Picrosirius Red to determine collagen expression. Real-time PCR was performed to analyze gene expression of IL-6, tenomodulin, type I and type II collagen, MMP-9, TIMP-1, and TIMP-2. RESULTS: Collagenase injection resulted in significantly higher gene expression of IL-6 but significantly lower tenomodulin expression compared with the control in SAMP6 and SAMR1 mice. In SAMP6 mice, gene expression of type III collagen and MMP-9 was significantly higher in the collagenase-injected group compared with the control group. SAMP6 mice also showed lower expression of type I collagen, TIMP-1, and TIMP-2 in the collagenase-injected group compared with the control group. Picrosirius Red staining showed the highest expression of type III collagen in the collagenase-injected SAMP6 group compared with the other groups. CONCLUSIONS: The collagenase-injected SAMP6 group showed higher expression of IL-6, MMP-9, and type III collagen and lower expression of type I collagen, TIMP-1, and TIMP-2, which are known to suppress metalloproteinases. The results indicate that aging may lead to dysfunction of the tendon healing process after acute tendon injury.

  Mar. 2019, BMC musculoskeletal disorders, 20(1) (1), 120 - 120, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 骨釘による指関節固定を行った化膿性DIP関節炎の2例

  中林 大治, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒田 良祐

  骨釘を用いて関節固定を行った化膿性指関節炎2例を呈示した。症例1は30歳男性で、魚の背びれが右中指に刺さったことを契機に発症した。症例2は71歳男性で、右中指爪周囲炎の保存加療中に発症した。患者が多数回の手術を拒否したため一期的手術を選択し、病巣を掻把後に肘頭から採取した骨釘による関節固定を行った。症例1はZiehl-Neelsen染色の結果、非結核性抗酸菌感染の診断で6ヵ月間のCAM、EB、RFPの内服を行った。症例2は培養検査よりMSSAを検出したため12週間のCEX内服を行った。その後、2例ともに感染の再燃は無く、骨癒合が得られた。

  (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(2) (2), 225 - 226, Japanese


• 手根管症候群の母指球筋萎縮に対する肉眼的評価と超音波検査による評価の対比

  名倉 一成, 金谷 貴子, 原田 義文, 鷲見 正敏, 乾 淳幸, 美舩 泰, 黒田 良祐

  (株)医学書院, Mar. 2019, 臨床整形外科, 54(3) (3), 285 - 288, Japanese


• 胸腰椎椎体骨折におけるTrabecular Bone Score(TBS)とBone Mineral Density(BMD)とFRAXの骨折予測因子としての可能性 TBSの骨折予測因子としての働き

  西本 華子, 乾 淳幸, 美舩 泰, 新倉 隆宏, 楊 鴻生, 鷲見 正敏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Feb. 2019, 日本骨粗鬆症学会雑誌, 5(1) (1), 140 - 146, Japanese


• A case of a painful coalition between pisiform and hamate.

  Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Takahiro Niikura, Ryosuke Kuroda

  We report a case of the pisiform and hamate coalition in 13-years-old male. Interoperative findings revealed that the ulnar nerve runs over the hook of the hamate which is the nonanatomic site. Surgical resection of pisiform relieved the pain.

  2019, Case reports in plastic surgery & hand surgery, 6(1) (1), 35 - 37, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Case Series of Comminuted Olecranon Fracture Treated by Plate Fixation; Do We Have to Remove the Plate?

  Atsuyuki Inui, Tsukasa Kuroda, Takashi Kurosawa, Takeshi Kokubu, Yutaka Mifune, Hanako Nishimoto, Ryosuke Kuroda

  Comminuted olecranon fracture requires surgical intervention. Plate fixation has been performed on the majority of cases. We reviewed the cases of comminuted olecranon fracture in young and middle age treated by plate osteosynthesis and analyzed the functional outcome, complications and ratio and timing of hardware removal. Fifteen cases of comminuted olecranon fractures treated by plate fixation were reviewed. Bone union was achieved in all cases, the average range of motion at the final follow up was -11° in extension, 133° in flexion, 89° in pronation and 88° in supination. Hardware removal performed in 12 cases in average 8.3 months postoperatively, in 2 cases elbow joint contracture release was performed during the hardware removal. In the co-payment (+) group, 4 cases (67%) removed the plate at average six months postoperatively. On the other hand, no co-payment group (workman's compensation insurance or automobile liability insurance) underwent hardware removal surgery in 8 cases (89%) at 9.6 months postoperatively. There was no statistical difference between the timing or prevalence of hardware removal between the groups. The present study showed high removal rate of hardware despite the excellent clinical result. The surgeons should be aware that plate fixation of the olecranon fracture requires the removal of a plate in the majority of cases.

  Nov. 2018, The Kobe journal of medical sciences, 64(3) (3), E115-E118 - E118, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 尺骨近位部骨折に対するプレート固定術の治療成績

  黒澤尭, 美舩泰, 山裏耕平, 黒田司

  (一社)日本骨折治療学会, Sep. 2018, 骨折, 40(4) (4), 930 - 932, Japanese

  [Refereed]


• Rotator cuff tear healing process with graft augmentation of fascia lata in a rabbit model.

  Takeshi Kataoka, Takeshi Kokubu, Tomoyuki Muto, Yutaka Mifune, Atsuyuki Inui, Ryosuke Sakata, Hanako Nishimoto, Yoshifumi Harada, Fumiaki Takase, Yasuhiro Ueda, Takashi Kurosawa, Kohei Yamaura, Ryosuke Kuroda

  BACKGROUND: Fascia lata augmentation of massive rotator cuff tears has shown good clinical results. However, its biological effect during the early healing process is not clearly understood. The purpose of the study was to evaluate the biological efficacy of fascia lata augmentation during the early healing process of rotator cuff tears using a rabbit rotator cuff defect model. METHODS: The infraspinatus tendon was resected from the greater tuberosity of a rabbit to create a rotator cuff tear. The tendon edge was directly sutured to the humeral head. The rotator cuff repaired site was augmented with a fascia lata autograft (augmentation group, group A). The rotator cuff defect in the contralateral shoulder was repaired without augmentation (reattachment group, group R). A group with intact rotator cuff was set as the control group. Histological examinations and mechanical analysis were conducted 4 and 8 weeks postoperatively. RESULTS: In the HE staining, the tendon maturing score of group A was higher than that of group R at 4 weeks postoperatively. In the safranin O staining, proteoglycan staining at the repaired enthesis in group A at 4 weeks postoperatively was stronger than that in group R. Picrosirius red staining showed that type III and type I collagen in group A was more strongly expressed than that in group R at 4 weeks postoperatively. The ultimate failure load of the infraspinatus tendon-humeral head complex in group A was statistically higher than that in group R at 4 weeks postoperatively. The ultimate failure load of group A was similar to that of the control group. CONCLUSION: The biological and mechanical contribution of fascia lata augmentation for massive rotator cuff tears was analyzed in this study. Type III collagen was reported to be expressed during the tendon healing process. Although the biological action similar to natural ligament healing occurred around the fascia lata grafts, type III collagen was gradually replaced by type I collagen as the tissue matured. Our results suggest that fascia lata augmentation could stimulate biological healing and provide initial fixation strength of the repaired rotator cuff.

  Aug. 2018, Journal of orthopaedic surgery and research, 13(1) (1), 200 - 200, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Association of advanced glycation end products in Dupuytren disease.

  Fumiaki Takase, Yutaka Mifune, Atsuyuki Inui, Yasuhiro Ueda, Takeshi Kataoka, Takeshi Kokubu, Ryosuke Kuroda

  BioMed Central Ltd., Jun. 2018, Journal of orthopaedic surgery and research, 13(1) (1), 143 - 143, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Transcutaneous carbon dioxide application with hydrogel prevents muscle atrophy in a rat sciatic nerve crush model.

  Hanako Nishimoto, Atsuyuki Inui, Takeshi Ueha, Miho Inoue, Shiho Akahane, Risa Harada, Yutaka Mifune, Takeshi Kokubu, Kotaro Nishida, Ryosuke Kuroda, Yoshitada Sakai

  John Wiley and Sons Inc., Jun. 2018, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 36(6) (6), 1653 - 1658, English, International magazine

  [Refereed]

  Scientific journal


• The effects of high glucose condition on rat tenocytes in vitro and rat Achilles tendon in vivo

  Ueda Y, Inui A, Mifune Yutaka, Sakata R, Muto T, Harada Y, Takase F, Kataoka T, Kokubu T, Kuroda Ryosuke

  Jun. 2018, Bone Joint Res, 7(5) (5), 362 - 372, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Treatment of Chronic Bony Mallet Fingers by Dorsal Extension Block Pinning with Percutaneous Curettage.

  Fumiaki Takase, Kyoko Yamasaki, Takeshi Kokubu, Yutaka Mifune, Atsuyuki Inui, Ryosuke Kuroda

  Dorsal extension block pinning is a commonly performed surgical technique for acute bony mallet fingers. However, the treatment of chronic bony mallet finger remains controversial. We investigated the use of dorsal extension block pinning with percutaneous curettage for chronic bony mallet fingers. Seven patients with chronic bony mallet fingers were treated by dorsal extension block pinning with percutaneous curettage. The average age was 17 (range, 12-23) years, and the average time from injury to surgery was 20 (range, 7-49) weeks. Bone union was achieved in all patients. None of the patients experienced pain after bone union. The average loss of distal interphalangeal joint extension was 6 (range, 5-20) degrees, and the average flexion was 59 (range, 40-80) degrees. The Crawford functional score was excellent in three patients, good in two, and fair in two. Dorsal extension block pinning with percutaneous curettage could be a useful treatment for chronic bony mallet fingers.

  2018, Case reports in orthopedics, 2018, 7297951 - 7297951, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Olecranon Apophyseal Nonunion in Adolescent Judo Players: A Report of Two Cases.

  Kohei Yamaura, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Yasuhiro Ueda, Takeshi Kataoka, Takashi Kurosawa, Shintaro Mukohara, Takeshi Kokubu, Ryosuke Kuroda

  Olecranon apophyseal nonunion is an elbow injury from overuse that affects adolescent athletes such as baseball pitchers who participate in overhead throwing sports. However, such injury is rare in collision sports. Here, we report two patients with this condition who are Judo athletes. The purpose of this report was to describe three elbows with olecranon apophyseal nonunion in two adolescent patients participating in Judo. This is a case series; the level of evidence is 4. Two 15-year-old patients were evaluated. One suffered from unilateral and the other from bilateral chronic posterior elbow pain. They were diagnosed with olecranon apophyseal nonunion, which was treated using internal fixation and bone grafting. Radiographic evidence of the apophyseal union was observed four months postsurgery. Two elbows were treated with tension band wiring, then they underwent hardware removal six months postsurgery. Both patients returned to their previous levels of activities six months postsurgery. Internal fixation using autologous bone grafting was a useful treatment for these Judo athletes with olecranon apophyseal nonunion.

  2018, Case reports in orthopedics, 2018, 8256074 - 8256074, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• リバース型人工肩関節置換術の関節窩側スクリュー挿入設置の検討

  国分毅, Mifune Yutaka, 高瀬史明, 植田安洋, 片岡武史, 黒澤尭

  (一社)日本肩関節学会, Nov. 2017, 肩関節, 41(3) (3), 813 - 816, Japanese

  [Refereed]


• Cuff tear arthropathyに合併した肩鎖関節部嚢腫の1例

  黒澤尭, 国分毅, Mifune Yutaka, 高瀬史明, 植田安洋, 片岡武史

  (一社)日本肩関節学会, Sep. 2017, 肩関節, 41(2) (2), 637 - 639, Japanese

  [Refereed]


• Effect of platelet-rich plasma on degeneration change of rotator cuff muscles: In vitro and in vivo evaluations.

  Fumiaki Takase, Atsuyuki Inui, Yutaka Mifune, Ryosuke Sakata, Tomoyuki Muto, Yoshifumi Harada, Yasuhiro Ueda, Takeshi Kokubu, Masahiro Kurosaka

  Aug. 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 35(8) (8), 1806 - 1815, English, International magazine

  [Refereed]

  Scientific journal


• 臨床経験 肩腱板断裂に対するステロイド関節内注射の効果の検討

  坂田亮介, Mifune Yutaka, 原田義文, 高瀬史明, 植田安洋, 片岡武史, 国分毅

  (株)医学書院, May 2017, 臨床整形外科, 52(5) (5), 491 - 495, Japanese

  [Refereed]


• 糖負荷が腱細胞に及ぼす影響の検討

  植田安洋, Mifune Yutaka, 坂田亮介, 無藤智之, 原田義文, 高瀬史明, 片岡武史, 国分毅

  糖負荷がラットアキレス腱細胞に及ぼす影響について検討した。正常ラットアキレス腱細胞を高グルコース培地で培養した群(高グルコース群)と通常グルコース培地で培養した群(対照群)に分け、比較した。その結果、高グルコース群では腱細胞におけるNOX1、NOX4の発現量が増加し、酸化ストレスとなるROSの産生の増加を認めた。更に腱の主要構成成分である1型コラーゲンの発現が減少し、細胞増殖活性の低下がみられた。以上より、糖尿病における腱障害の一因として高血糖によって生じた酸化ストレスが関与している可能性が示唆された。

  (一社)日本肩関節学会, Mar. 2017, 肩関節, 40(3) (3), 1005 - 1008, Japanese

  [Refereed]


• Rotator cuff repair using cell sheets derived from human rotator cuff in a rat model.

  Yoshifumi Harada, Yutaka Mifune, Atsuyuki Inui, Ryosuke Sakata, Tomoyuki Muto, Fumiaki Takase, Yasuhiro Ueda, Takeshi Kataoka, Takeshi Kokubu, Ryosuke Kuroda, Masahiro Kurosaka

  Feb. 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 35(2) (2), 289 - 296, English, International magazine

  [Refereed]

  Scientific journal


• Effects of platelet-rich plasma and triamcinolone acetonide on interleukin-1β-stimulated human rotator cuff-derived cells

  T. Muto, T. Kokubu, Y. Mifune, A. Inui, R. Sakata, Y. Harada, F. Takase, M. Kurosaka

  British Editorial Society of Bone and Joint Surgery, Dec. 2016, Bone and Joint Research, 5(12) (12), 602 - 609, English

  Scientific journal


• Arthroscopic Rotator Cuff Repair With Graft Augmentation of Fascia Lata for Large and Massive Tears.

  Takeshi Kokubu, Yutaka Mifune, Atsuyuki Inui, Ryosuke Kuroda

  Elsevier B.V., Dec. 2016, Arthroscopy techniques, 5(6) (6), e1235-e1238 - e1238, English, International magazine

  [Refereed]

  Scientific journal


• High-resolution ultrasound in the diagnosis of trigger finger and evaluation of response to steroid injection.

  Yutaka Mifune, Atsuyuki Inui, Ryosuke Sakata, Yoshifumi Harada, Fumiaki Takase, Masahiro Kurosaka, Takeshi Kokubu

  Dec. 2016, Skeletal radiology, 45(12) (12), 1661 - 1667, English, International magazine

  [Refereed]

  Scientific journal


• 橈骨遠位端骨折に対するAPTUS2.5の使用経験

  原田義文, Kokubu Takeshi, Mifune Yutaka, 乾淳幸, 片岡武史, 黒坂昌弘

  平成24年〜25年の28例28手(男3例、女25例、平均年齢69歳)を対象とした。AO分類による骨折型はA-2が3例、A-3が5例、B-2が4例、B-3が8例、C-1が4例、C-2が2例、C-3が2例であった。関節可動域は掌屈・背屈ともに術後2週と比較して有意に改善し、握力も術後4週と比較して有意に改善した。Modified Mayo wrist scoreは術後6ヵ月で70%がgood以上であり、平均81点であった。Poorは0%であったがsatisfactoryは30%存在し、そのうち62.5%は関節内骨折であった。単純X線による矯正損失は術直後と最終評価時のvolar tilt、radial inclination、ulnar valianceいずれも有意差を認めなかった。1例で術後4週に正中神経領域に痺れを自覚し、手根管症候群の診断で手根管開放術を施行した。

  (一社)中部日本整形外科災害外科学会, Nov. 2016, 中部日本整形外科災害外科学会雑誌, 59(6) (6), 1115 - 1116, Japanese

  [Refereed]


• 高齢ラットにおける腱板組織への糖化最終生成物沈着の検討

  Mifune Yutaka, 乾淳幸, 坂田亮介, 原田義文, 高瀬史明, 植田安洋, 片岡武史, Kokubu Takeshi

  近年、老化の原因として糖化最終生成物(AGEs)が注目されている。著者等は以前、in vitroの実験においてAGEsが腱板由来細胞の活性酸素発現を増加させ、アポトーシス率を上昇させることを明らかにした。今回、高齢ラットを用いて、加齢に伴い腱板組織へのAGEs沈着量および腱板組織のアポトーシス発現量、腱板の力学的強度がどのように変化するか検討した。結果、AGEs沈着量とアポトーシス発現量は有意に増加し、力学的強度は有意に低下した。

  (一社)日本肩関節学会, Oct. 2016, 肩関節, 40(2) (2), 476 - 480, Japanese

  [Refereed]


• Ultrasound measurement of median nerve cross-sectional area at the inlet and outlet of carpal tunnel after carpal tunnel release compared to electrodiagnostic findings.

  Atsuyuki Inui, Hanako Nishimoto, Yutaka Mifune, Takeshi Kokubu, Ryosuke Sakata, Masahiro Kurosaka

  Sep. 2016, Archives of orthopaedic and trauma surgery, 136(9) (9), 1325 - 1330, English, International magazine

  [Refereed]

  Scientific journal


• 四肢骨格筋量は高齢者QOLに影響を及ぼすのか? 骨格筋指数とEQ-5Dを用いたQOL評価の相関関係

  西本華子, 乾淳幸, 笠原孝一, Sakai Yoshitada, Kuroda Ryosuke, 黒坂昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 332 - 332, Japanese

  [Refereed]


• 腋窩動脈損傷を伴った上腕骨近位部骨折の治療経験

  乾淳幸, Mifune Yutaka, 原田義文, 高瀬史明, 植田安洋, 黒坂昌弘

  (一社)日本骨折治療学会, Jun. 2016, 骨折, 38(3) (3), 577 - 580, Japanese

  [Refereed]


• 神経圧挫モデルでの神経・筋肉機能回復過程における炭酸ガス経皮吸収の効果について

  西本華子, 乾淳幸, 上羽岳志, 赤羽志保, 高瀬史明, 植田安洋, Kokubu Takeshi, Kurosaka Masahiro, Sakai Yoshitada

  (公社)日本リハビリテーション医学会, Jun. 2016, 日本整形外科学会雑誌, 89(JARM2016) (JARM2016), I238 - I238, Japanese


• 骨吸収マーカーTRACP-5bとHip Structural Analysisにおける断面係数の相関関係

  西本華子, 乾淳幸, Kuroda Ryosuke, 黒坂昌弘, Sakai Yoshitada

  (公社)日本リハビリテーション医学会, Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I17 - I17, Japanese

  [Refereed]


• Characterization of progenitor cells derived from torn human rotator cuff tendons by gene expression patterns of chondrogenesis, osteogenesis, and adipogenesis.

  Issei Nagura, Takeshi Kokubu, Yutaka Mifune, Atsuyuki Inui, Fumiaki Takase, Yasuhiro Ueda, Takeshi Kataoka, Masahiro Kurosaka

  Mar. 2016, Journal of orthopaedic surgery and research, 11, 40 - 40, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 金属アレルギーを伴う鎖骨偽関節に対して生体吸収素材を用いて骨接合を施行した1例

  大西洋輝, Kokubu Takeshi, Mifune Yutaka, 乾淳幸, 坂田亮介, 黒坂昌弘

  症例は74歳男性で、交通事故により右鎖骨骨幹部骨折を受傷した。受傷後2週にチタン製プレートを用いた観血的骨接合術が施行されたが、骨癒合は得られなかった。著者等の病院を紹介受診し、初診時の身体所見で右鎖骨部から前胸部にかけて広範囲に発赤を認めた。単純X線で鎖骨のプレートの明らかな破損は認められなかった。感染徴候に乏しかったため、金属アレルギーの可能性を考慮し金属パッチテストを行った。その結果、Coが陽性、Ti、Mn、Znが弱陽性であった。皮膚症状は金属アレルギーによるものと考え、ステロイド外用剤による治療を行った。受傷後9ヵ月の時点で偽関節となったため、生体吸収素材と自家骨移植を用いた観血的骨接合術を施行した。術後3ヵ月のCT画像で骨癒合が確認された。生体吸収素材は金属アレルギーにより金属製インプラントが使えない場合に有用な骨接合材の一つになり得ると考えられた。

  (一社)中部日本整形外科災害外科学会, Mar. 2016, 中部日本整形外科災害外科学会雑誌, 59(2) (2), 403 - 404, Japanese

  [Refereed]


• Regulation of lubricin/superficial zone protein by Wnt signalling in bovine synoviocytes.

  Atsuyuki Inui, Takashi Iwakura, A Hari Reddi

  Lubricin, homologous to superficial zone protein (SZP), functions as a boundary lubricant in articular cartilage and plays an essential role in the maintenance of joint function and homeostasis. Wnt signalling plays a key role in joint development, including synovial joint formation, and several Wnt proteins are expressed in the synovium and articular cartilage in arthritis. The aim of this study was to determine the role of Wnt signalling on SZP accumulation in synoviocytes. Isolated synoviocytes from bovine knee joints were cultured with Wnt proteins (Wnt-3a and Wnt-5a) and antagonists or agonists of the Wnt-β-catenin pathway or Wnt-Ca(2+) pathway in serum-free chemically defined medium. SZP accumulation in the culture medium was determined by enzyme-linked immunosorbent assay. Wnt-3a suppressed SZP accumulation via a Wnt-β-catenin-dependent pathway. In contrast, Wnt-5a stimulated SZP accumulation via a β-catenin independent pathway. The present investigation provides novel insights into the role of the Wnt signalling pathways in SZP accumulation in synoviocytes and their roles in the homeostasis of normal joints.

  Feb. 2016, Journal of tissue engineering and regenerative medicine, 10(2) (2), 172 - 7, English, International magazine

  Scientific journal


• Two Extension Block Kirschner Wires' Technique for Bony Mallet Thumb.

  Yutaka Mifune, Atsuyuki Inui, Fumiaki Takase, Yasuhiro Ueda, Issei Shinohara, Ryosuke Kuroda, Takeshi Kokubu

  Mallet fingers with an avulsion fracture of the distal phalanx or rupture of the terminal tendon of the extensor mechanism is known as a common injury, while mallet thumb is very rare. In this paper, the case of a 19-year-old woman with a sprained left thumb sustained while playing basketball is presented. Plain radiographs and computed tomography revealed an avulsion fracture involving more than half of the articular surface at the base of the distal phalanx. Closed reduction and percutaneous fixation were performed using the two extension block Kirschner wires' technique under digital block anesthesia. At 4 months postoperatively, the patient had achieved excellent results according to Crawford's evaluation criteria and had no difficulties in working or playing basketball. Various conservative and operative treatment strategies have been reported for management of mallet thumb. We chose the two extension block Kirschner wires' technique to minimize invasion of the extensor mechanism and nail bed and to stabilize the large fracture fragment.

  2016, Case reports in orthopedics, 2016, 8086594 - 8086594, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 肘部管症候群に対するPain Visionを用いた疼痛の定量的評価

  国分毅, 美舩泰, 西本華子, 無藤智之, 原田義文, 高瀬史明, 植田安洋

  日本肘関節学会, Dec. 2015, 日本肘関節学会雑誌, 22(2) (2), 373 - 375, Japanese

  [Refereed]


• 超高周波プローブを用いたエコーによる前腕表在神経の観察

  山崎善功, 乾淳幸, Kokubu Takeshi, Mifune Yutaka, 高瀬史明, Kurosaka Masahiro

  健常者41名82手(平均年齢32歳)を対象に、エコーを用いて前腕表在神経を観察した。エコー装置は22MHz高周波プローブを用いて、前腕での内側前腕皮神経および橈骨神経浅枝と静脈との位置関係を観察した。内側前腕皮神経と尺側皮静脈は肘関節皮線のレベルで固定し、次に橈骨神経浅枝と橈側皮静脈を橈骨茎状突起のレベルで固定した。各々について脈管と神経、体表から神経までの深さを測定し、Lichtらの分類により脈管と神経との距離が2mm未満である群を神経誤穿刺のhigh risk群とした。その結果、内側前腕皮神経と尺側皮静脈との距離の平均は1.4mmで、体表から神経までの深さの平均は4.4mmであった。High risk群の占める割合は34.6%であった。一方、橈骨神経浅枝と橈側皮静脈の距離の平均は1.1mmで、体表から神経までの深さの平均は2.7mmであった。High risk群の占める割合は82.7%であった。

  (一社)中部日本整形外科災害外科学会, Nov. 2015, 中部日本整形外科災害外科学会雑誌, 58(6) (6), 1139 - 1140, Japanese

  [Refereed]


• 腱板由来細胞シート移植による腱板修復部治癒の促進

  Mifune Yutaka, Kokubu Takeshi, 乾淳幸, 坂田亮介, 原田義文, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Sep. 2015, 中部日本整形外科災害外科学会雑誌, 58(秋季学会) (秋季学会), 264 - 264, Japanese


• 糖負荷が腱細胞に及ぼす影響の検討

  植田安洋, 乾淳幸, Mifune Yutaka, 無藤智之, 原田義文, 高瀬史明, Kokubu Takeshi, Kurosaka Masahiro

  (一社)日本肩関節学会, Sep. 2015, 日本整形外科学会雑誌, 42回(8号) (8号), 118 - 118, Japanese


• 中高年スポーツ競技者の肩腱板大・広範囲断裂に対する鏡視下腱板修復術の検討

  Kokubu Takeshi, Mifune Yutaka, 乾淳幸, 坂田亮介, 植田安洋, Kurosaka Masahiro

  肩腱板大・広範囲断裂に対して鏡視下腱板修復術を行った中高年スポーツ競技者13例の術後成績について検討した。その結果、全例で可動域は改善し、各臨床スコアおよび外転筋力は有意に回復した。術後半年のMRIにて再断裂を3例に認めた。再断裂例は非再断裂例と比べ、外転筋力が有意に低値を示した。スポーツ完全復帰率は85%(11例)と比較的良好であったが、他の2例は術前と同レベルにスポーツ復帰できず、いずれも再断裂例であった。

  (一社)中部日本整形外科災害外科学会, Sep. 2015, 中部日本整形外科災害外科学会雑誌, 58(5) (5), 1031 - 1032, Japanese

  [Refereed]


• 大・広範囲肩腱板断裂に対する大腿筋膜graft augmentation法を用いた鏡視下腱板修復術

  Kokubu Takeshi, Mifune Yutaka, 乾淳幸, 坂田亮介, 無藤智之, 原田義文, 高瀬史明, 植田安洋

  腱板断端を大結節まで引き出せない大・広範囲断裂肩腱板断裂症例20例(男性14例、女性6例:手術時平均年齢66.2歳)を対象に、内側の骨頭軟骨にsingle row(SR)法で縫着し、大腿筋膜でSR修復部を補強するgraft augmentation(GA)法による鏡視下腱板修復術を行った13例と従来のSR法7例の術後再断裂を評価し、臨床成績について検討した。その結果、術後MRIで再断裂はGA法2例(15%)、SR法6例(85%)に認めた。JOA、UCLA、Constantスコアは両群で術前より有意な改善を認め、GA法では外転筋力が有意に改善した。以上より、GA法は腱板の過緊張をさけて腱板修復を行うために再断裂予防が可能で、腱板大・広範囲断裂に対して有用な手術法であると考えられた。

  (一社)日本肩関節学会, Sep. 2015, 肩関節, 39(2) (2), 491 - 495, Japanese

  [Refereed]


• 金属アレルギーを伴う鎖骨偽関節に対して生体吸収素材を用い骨接合を施行した1例

  大西洋輝, Mifune Yutaka, Kokubu Takeshi, 乾淳幸, 坂田亮介, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Sep. 2015, 中部日本整形外科災害外科学会雑誌, 58(秋季学会) (秋季学会), 219 - 219, Japanese


• 筋脂肪分化におけるplatelet-rich-plasma投与効果の検討

  高瀬史明, 乾淳幸, Mifune Yutaka, 坂田亮介, 無藤智之, 原田義文, 植田安洋, Kokubu Takeshi, Kurosaka Masahiro

  (公社)日本整形外科学会, Sep. 2015, 日本整形外科学会雑誌, 89(8) (8), S1656 - S1656, Japanese


• マウス筋芽細胞の脂肪分化およびラット腱板断裂モデルにおけるplatelet-rich-plasma投与効果の検討

  高瀬史明, 乾淳幸, Mifune Yutaka, 坂田亮介, Kokubu Takeshi, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Sep. 2015, 中部日本整形外科災害外科学会雑誌, 58(秋季学会) (秋季学会), 265 - 265, Japanese


• Can Platelet-Rich Plasma Protect Rat Achilles Tendons From the Deleterious Effects of Triamcinolone Acetonide?

  Tomoyuki Muto, Takeshi Kokubu, Yutaka Mifune, Atsuyuki Inui, Ryosuke Sakata, Yoshifumi Harada, Fumiaki Takase, Yasuhiro Ueda, Ryosuke Kuroda, Masahiro Kurosaka

  SAGE Publications Ltd, Jul. 2015, Orthopaedic journal of sports medicine, 3(7) (7), 2325967115590968 - 2325967115590968, English, International magazine

  [Refereed]

  Scientific journal


• 陳旧性骨性槌指に対する経皮的骨接合術の小経験

  高瀬史明, Mifune Yutaka, 乾淳幸, 植田安洋, Kurosaka Masahiro

  (一社)日本骨折治療学会, Jun. 2015, 骨折, 37(Suppl.) (Suppl.), S269 - S269, Japanese


• 血管損傷を伴った上腕骨近位部骨折の治療経験

  乾淳幸, Mifune Yutaka, 高瀬史明, 植田安洋, Kurosaka Masahiro

  (一社)日本骨折治療学会, Jun. 2015, 骨折, 37(Suppl.) (Suppl.), S263 - S263, Japanese


• 腱板大・広範囲断裂に対する鏡視下大腿筋膜graft augmentation法の検討

  Kokubu Takeshi, Mifune Yutaka, 乾淳幸, 坂田亮介, 原田義文, 高瀬史明, 植田安洋, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4) (4), 172 - 172, Japanese


• Treatment and Diagnosis of Panner's Disease. A Report of Three Cases.

  Ryosuke Sakata, Hiroyuki Fujioka, Masaki Tomatsuri, Takeshi Kokubu, Yutaka Mifune, Atsuyuki Inui, Masahiro Kurosaka

  Avascular necrosis of the humeral capitellum (Panner's disease), a relatively rare disorder in the juvenile. We diagnosed three patients using radiographs and magnetic resonance imaging, who were previously misdiagnosed with osteochondritis dissecans of the humeral capitellum. All patients were successfully treated by restriction of sports activities using the upper extremities. It is often difficult to distinguish Panner's disease from osteochondritis dissecans of the humeral capitellum. Panner's disease has been reported to occur in boys between 7 and 10 years old, which is younger than susceptible age of osteochondritis dissecans. In MRI, low intensity area in the ossification center of the humeral capitellum in T1-weighted image is useful findings for diagnosis. For the treatment, the conservative treatment has been recommended in the early stage of Panner's disease, while surgical intervention is required in some cases of osteochondritis dissecans.

  Apr. 2015, The Kobe journal of medical sciences, 61(2) (2), E36-9, English, Domestic magazine

  Scientific journal


• 弾発指に対するステロイド腱鞘内注射の評価

  坂田亮介, 乾淳幸, Mifune Yutaka, 無藤智之, Kokubu Takeshi

  (一社)日本手外科学会, Apr. 2015, 日本手外科学会雑誌, 32(1) (1), 2 - 45, Japanese


• 腱板大・広範囲断裂に対する大腿筋膜graft augmentation法を用いた鏡視下腱板修復術

  Kokubu Takeshi, Mifune Yutaka, 乾淳幸, 無藤智之, 原田義文, 高瀬史明, 植田安洋, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2015, 日本整形外科学会雑誌, 89(3) (3), S924 - S924, Japanese


• 超高周波プローブを用いたエコーによる橈骨神経浅枝の解剖学的位置の検討

  乾淳幸, 山崎善功, Kokubu Takeshi, Mifune Yutaka, 無藤智之, 原田義文, 高瀬史明, 植田安洋, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2015, 日本整形外科学会雑誌, 89(3) (3), S503 - S503, Japanese


• 弾発指へのステロイド腱鞘内注射についての検討

  坂田亮介, Kokubu Takeshi, Mifune Yutaka, 乾淳幸, 原田義文, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Mar. 2015, 中部日本整形外科災害外科学会雑誌, 58(春季学会) (春季学会), 121 - 121, Japanese


• Pain visionを用いた手根管症候群のしびれの評価

  乾淳幸, Kokubu Takeshi, 美船泰, 西本華子, 原田義文, Kurosaka Masahiro

  (一社)日本手外科学会, Feb. 2015, 日本手外科学会雑誌, 31(5) (5), 709 - 711, Japanese

  [Refereed]


• Application of Pain Quantitative Analysis Device for Assessment of Postoperative Pain after Arthroscopic Rotator Cuff Repair.

  Yutaka Mifune, Atsuyuki Inui, Issei Nagura, Ryosuke Sakata, Tomoyuki Muto, Yoshifumi Harada, Fumiaki Takase, Masahiro Kurosaka, Takeshi Kokubu

  PURPOSE: The PainVision™ system was recently developed for quantitative pain assessment. Here, we used this system to evaluate the effect of plexus brachialis block on postoperative pain after arthroscopic rotator cuff repair. METHODS: Fifty-five patients who underwent arthroscopic rotator cuff repair were included in this study. First 26 cases received no plexus brachialis block (control group), and the next 29 cases received the plexus brachialis block before surgery (block group). Patients completed the visual analog scale at 4, 8, 16, and 24 hours after surgery, and the intensity of postoperative pain was assessed with PainVision™ at 16 hours. The postoperative use of non-steroidal anti-inflammatory agents was also recorded. RESULTS: The pain intensity at 16 hours after surgery assessed by PainVision™ was significantly lower in the block group than in the control group (block, 252.0 ± 47.8, control, 489.0 ± 89.1, P < 0.05). However, there were no differences in the VAS values at 16 hours between the 2 groups (block, 4.3 ± 0.6, control, 5.7 ± 0.4, P = N.S.). The pain intensity and VAS at 16 hours after surgery were highly correlated (r = 0.59, P = 0.006 in the block group and r = 0.62, P = 0.003 in the control group). The effect size of the assessment by PainVision™ was bigger than that of VAS (r=0.31 in VAS and 0.51 in Pain vision). CONCLUSION: The PainVision™ system could be useful to evaluate postoperative pain because it enables the quantification and comparison of pain intensity independent of individual pain thresholds.

  2015, The open orthopaedics journal, 9, 89 - 93, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Carpal Tunnel Syndrome Caused by Tumoral Calcinosis.

  Atsuyuki Inui, Takahiro Suzuki, Takeshi Kokubu, Ryosuke Sakata, Yutaka Mifune, Masahiro Kurosaka

  We present a case of carpal tunnel syndrome caused by systemic tumoral calcinosis. A 54-year-old woman experienced hand numbness that persisted for nine months. She had no family history or medical problem. A plain radiograph of her right wrist showed a calcified mass on the volar side of the wrist joint. The patient also experienced pain in her contralateral wrist joint and both right and left shoulders, which had calcification on radiography around the joint. Her condition was diagnosed as carpal tunnel syndrome caused by systemic tumoral calcinosis and a resection biopsy was performed. Histopathological analysis of the biopsied specimen showed basophile deposition inside the fibrous connective tissue. At 14 months after the treatment, she no longer had pain or numbness in her fingers and there was no recurrence of the mass. This patient's condition is considered as a case of nonfamilial, systemic primary tumoral calcinosis. Since incomplete resection leads to a recurrence of the lesion, a follow-up radiography examination is needed to monitor symptom recurrence.

  2015, Case reports in orthopedics, 2015, 170873 - 170873, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Dose- and time-dependent effects of triamcinolone acetonide on human rotator cuff-derived cells

  Kokubu Takeshi, Mifune Yutaka, Kurosaka Masahiro

  Dec. 2014, Bone Joint Res, 3(12) (12), 328 - 34, English

  [Refereed]

  Scientific journal


• A new bioabsorbable cotton-textured synthetic polymer scaffold for osteochondral repair.

  Ryosuke Sakata, Takeshi Kokubu, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Hiroyuki Fujioka, Ryosuke Kuroda, Masahiro Kurosaka

  PURPOSE: We have previously reported that a cylindrical bioabsorbable synthetic polymer scaffold made of poly (DL-lactide-co-glycolide) (PLG) can be used to repair osteochondral defects without using cultured cells in a rabbit model. This cylindrical scaffold has a solid and pre-formed design, which limits its widespread application. Therefore, we created a cotton-textured PLG scaffold, which would be superior to other scaffolds in terms of plastic property and operability. The purpose of the present study was to examine the efficacy of the cotton-textured PLG scaffold in the repair of osteochondral defects. METHODS: Cotton-textured PLG scaffolds were prepared using the electrospinning method and used to repair osteochondral defects produced on the right femoral condyle in 36 rabbits. As a control, the defect was left untreated. The outcomes of repair were examined histologically at postoperative weeks four, eight, and 12. RESULTS: In the untreated control group, the surface of the defect remained concave and the regenerated cartilaginous tissue partially covered the articular surface even at postoperative week 12. In the scaffold group, cartilaginous tissue covered the surface of the defect at postoperative week four, and the surface was smooth and the cartilaginous tissue was well regenerated and integrated with the native cartilage at postoperative week 12. CONCLUSIONS: The cotton-textured PLG scaffold could repair the osteochondral defect with good outcomes similar to those previously reported for the cylindrical scaffold, with its characteristic advantages of better plasticity and operability. We conclude that the cotton-textured PLG scaffold has potential for clinical application in comminuted osteochondral injury.

  Nov. 2014, International orthopaedics, 38(11) (11), 2413 - 20, English, International magazine

  [Refereed]

  Scientific journal


• Temporary inductions of matrix metalloprotease-3 (MMP-3) expression and cell apoptosis are associated with tendon degeneration or rupture after corticosteroid injection.

  Tomoyuki Muto, Takeshi Kokubu, Yutaka Mifune, Atsuyuki Inui, Yoshifumi Harada, Yoshifumi, Fumiaki Takase, Ryosuke Kuroda, Masahiro Kurosaka

  Corticosteroid injections are widely used to treat enthesopathy and tendinitis, but are also associated with possible side effects, such as tendon degeneration or rupture. However, the mechanism of tendon degeneration or rupture after corticosteroid injection remains controversial. The purpose of this study was to reveal the mechanism of tendon degeneration or rupture after injection of triamcinolone acetonide (TA) or prednisolone (PSL). Forty-two rats were divided into 3 groups: A normal saline injection group (control group), a TA injection group, and a PSL injection group; the normal saline or corticosteroid was injected around the Achilles tendon. One or 3 weeks after injection, the tendons were subjected to biomechanical testing and histological analysis. At 1 week, the biomechanical strength was significantly lower in the corticosteroid groups. Histological analysis, at 1-week post-injection, showed collagen attenuation, increased expression of MMP-3 and apoptotic cells in the corticosteroid groups. The histological changes and biomechanical weaknesses of the tendon were not seen at 3 weeks. These alterations appeared to be involved in tendon degeneration or rupture after corticosteroid injection.

  Oct. 2014, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(10) (10), 1297 - 304, English, International magazine

  [Refereed]

  Scientific journal


• 巨大骨嚢胞を伴った肘関節症に対して半拘束型の人工肘関節置換術を行った1例

  Kokubu Takeshi, Mifune Yutaka, Kurosaka Masahiro

  71歳男。13年来の両肘関節の痛みがあり、保存的加療を行った。疼痛が悪化し、夜間痛も出現した。単純X線では両肘の高度な関節破壊と右尺骨近位部に巨大な骨透過像を認めた。ACR/EULARのRA新分類基準では分類基準スコアが5点で関節リウマチには分類されなかった。骨嚢胞性変化を認めない左肘に対して人工肘関節置換術を施行した。同時に施行した右尺骨骨嚢胞の病理診断で、孤立性骨嚢胞および非特異的な滑膜炎と診断した。関節炎に対してはサラゾスルファピリジンの内服加療を開始した。3ヵ月後、右肘に対して人工肘関節置換術を施行した。術後は約3週のシーネ固定後、自動運動を中心としたリハビリテーションを開始した。術後4ヵ月での右肘の可動域は伸展-30°、屈曲140°であり、疼痛なく経過良好である。

  (一社)中部日本整形外科災害外科学会, Sep. 2014, 中部日本整形外科災害外科学会雑誌, 57(5) (5), 1061 - 1062, Japanese

  [Refereed]


• Immunohistochemical Localization of Bone Morphogenetic Proteins (BMPs) and their Receptors in Solitary and Multiple Human Osteochondromas.

  Araceli Cuellar, Atsuyuki Inui, Michelle A James, Dariusz Borys, A Hari Reddi

  The expression of bone morphogenetic proteins (BMPs) and their cognate receptors (BMPRs) in osteochondromas has not been investigated. We determined the immunohistochemical localization and distribution of BMP-2/4, -6 and -7; BMP receptors BMPR-1A, BMPR-1B and BMPR-2; signal transducing proteins phosphorylated Smad1/5/8; and BMP antagonist noggin in the cartilaginous cap of solitary (SO) and multiple (MO) human osteochondromas and compared these with bovine growth plate and articular cartilage. The distribution and localization patterns for BMP-6, BMP-7, BMPR-1A and BMPR-2 were similar between the cartilaginous cap and the growth plate. BMP-2/4 and BMPR-1B were present throughout the growth plate. However, BMP-2/4 and phosphorylated Smad1/5/8 were mainly detected in proliferating chondrocytes of the cartilaginous cap. Also, BMPR-1B was found in hypertrophic chondrocytes of SO and proliferating chondrocytes of MO. Noggin was observed in resting chondrocytes and, to a lesser extent, in clustered proliferating chondrocytes in SO. On the other hand, noggin in MO was observed in proliferating chondrocytes. Since BMPs can stimulate proliferation and hypertrophic differentiation of chondrocytes, these findings suggest that there is an imbalance of BMP-2/4 and noggin interactions that may lead to abnormal regulation of chondrocyte proliferation and differentiation in the cartilaginous cap of human osteochondromas.

  Jul. 2014, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 62(7) (7), 488 - 98, English, International magazine

  Scientific journal


• 鏡視下スーチャーブリッジ腱板修復術後の腱板再断裂症例の検討

  Kokubu Takeshi, Mifune Yutaka, Kurosaka Masahiro

  スーチャーブリッジ法による鏡視下肩腱板修復術を行った腱板完全断裂51例を対象に、MRIを用いて術後の再断裂について検討した。その結果、術後6ヵ月のMRIで再断裂は9例(17.6%)に認めた。再断裂の形態は、Choらの分類でType 1が2例(22.2%)、Type 2が7例(77.8%)であった。再断裂群は再断裂なし群と比較し、術前断裂サイズ3cm以上が有意に多く、術前棘上筋の筋萎縮率が有意に高かった。

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2014, JOSKAS:, 39(1) (1), 36 - 37, Japanese

  [Refereed]


• 皮質骨付き腸骨移植を併用した舟状骨骨折偽関節に対する骨接合術の治療成績

  乾 淳幸, Kokubu Takeshi, Mifune Yutaka, 西本 華子, 牧野 健

  (一社)日本手外科学会, Feb. 2014, 日本手外科学会雑誌:, 30(5) (5), 737 - 739, Japanese

  [Refereed]


• Management of intolerance to casting the upper extremities in claustrophobic patients.

  Issei Nagura, Takako Kanatani, Masatoshi Sumi, Atsuyuki Inui, Yutaka Mifune, Takeshi Kokubu, Masahiro Kurosaka

  INTRODUCTION: Some patients showed unusual responses to the immobilization without any objective findings with casts in upper extremities. We hypothesized their that intolerance with excessive anxiety to casts is due to claustrophobia triggered by cast immobilization. The aim of this study is to analyze the relevance of cast immobilization to the feeling of claustrophobia and discover how to handle them. METHODS: There were nine patients who showed the caustrophobic symptoms with their casts. They were assesed whether they were aware of their claustrophobis themselves. Further we investigated the alternative immobilization to casts. RESULTS: Seven out of nine cases that were aware of their claustrophobic tendencies either were given removable splints initially or had the casts converted to removable splints when they exhibited symptoms. The two patients who were unaware of their latent claustrophobic tendencies were identified when they showed similar claustrophobic symptoms to the previous patients soon after short arm cast application. We replaced the casts with removable splints. This resolved the issue in all cases. CONCLUSIONS: We should be aware of the claustrophobia if patients showed unusual responses to the immobilization without any objective findings with casts in upper extremities, where removal splint is practical alternative to cast to continue the treatment successfully.

  2014, TheScientificWorldJournal, 2014, 803047 - 803047, English, International magazine

  [Refereed]

  Scientific journal


• 上腕骨小頭離断性骨軟骨炎に対する保存療法での投球復帰の検討

  Kokubu Takeshi, Mifune Yutaka, 乾 淳幸, 無藤 智之, 原田 義文, 高瀬 史明

  日本肘関節学会, Jan. 2014, 日本肘関節学会雑誌, 21(1) (1), S96 - S96, Japanese

  [Refereed]


• Concurrent rotator cuff tear and axillary nerve palsy associated with anterior dislocation of the shoulder and large glenoid rim fracture: a "terrible tetrad".

  Fumiaki Takase, Atsuyuki Inui, Yutaka Mifune, Tomoyuki Muto, Yoshifumi Harada, Takeshi Kokubu, Masahiro Kurosaka

  We present a case of concurrent rotator cuff tear and axillary nerve palsy resulting from anterior dislocation of the shoulder and a large glenoid rim fracture-a "terrible tetrad." A 61-year-old woman fell on her right shoulder. Radiographs showed anterior dislocation of the shoulder with a glenoid rim fracture, and an MRI two months after injury revealed a rotator cuff tear. Upon referral to our hospital, physical and electrophysiological examinations revealed axillary nerve palsy. The axillary nerve palsy was incomplete and recovering, and displacement of the glenoid rim fracture was minimal and already united; therefore, we surgically repaired only the rotator cuff tear three months after injury. The patient recovered satisfactorily following the operation. In patients whose axillary nerve palsy is recovering, surgeons should consider operating on rotator cuff tears in an attempt to prevent rotator cuff degeneration.

  2014, Case reports in orthopedics, 2014, 312968 - 312968, English, International magazine

  [Refereed]

  Scientific journal


• 手根管症候群に対してPain Visionを用いた上肢機能障害評価の試み

  Kokubu Takeshi, Mifune Yutaka, Kurosaka Masahiro

  手根管症候群に対してPain Visionを用いた上肢機能障害評価について検討した。手根管症候群と診断され正中神経支配領域に痺れを有する30手を対象とし、手術を受けていない症例は13手、手術を受けた症例は17手であった。正中神経を手関節部で刺激し、短母指外転筋で導出した際の運動神経終末潜時と痺れ度の相関係数は-0.15、感覚神経伝搬速度と痺れ度の相関係数は-0.21であった。軽症群の痺れ度は平均129±230、重症群の痺れ度は123±142で両群間に有意差は認めなかった。患者自身の自覚症状スコアであるNRSと痺れ度の相関係数は0.47、Quick-DASHと痺れ度の相関関数は0.14と、NRSと痺れ度については有意に相関関係を認めた。

  (一社)中部日本整形外科災害外科学会, Jan. 2014, 中部日本整形外科災害外科学会雑誌, 57(1) (1), 219 - 220, Japanese

  [Refereed]


• 外側アンカーの違いによるSuture Bridge法の術後成績の検討

  Kokubu Takeshi, Mifune Yutaka, 乾 淳幸, 西本 華子, 無藤 智之, 原田 義文, 名倉 一成

  Suture Bridge法での外側アンカーとしてPanalok loop RCを使用した群(15例)とFootprint PKを使用した群(15例)の成績を比較検討した。比較項目は「使用アンカー数」「外側アンカー1個に対して用いたbridging suture数」「手術時間」「JOA score(術前と術後6ヵ月時)」「Constant score(術前と術後6ヵ月時)」「再断裂率」とした。検討の結果、「外側アンカー1個に対して用いたbridging suture数」にのみ有意な群間差が認められ、Footprint PK使用群で多かった(3.3本 vs 2.0本)。

  (一社)日本肩関節学会, Sep. 2013, 肩関節, 37(2) (2), 697 - 700, Japanese

  [Refereed]


• 肩関節症に対する人工肩関節置換術の治療経験

  Kokubu Takeshi, Mifune Yutaka, Kurosaka Masahiro

  当科で人工肩関節置換術を施行した肩関節症6例の術後短期成績について検討した。男性2例、女性4例で、手術時年齢は平均70.2歳、術後経過観察期間は平均21.5ヵ月であった。その結果、JOAスコアは術前54.3点が術後91.6点へ有意に改善し、特に疼痛スコアが有意に改善した。UCLAスコアは14.3点が32.3点へ有意に改善した。術後1年までの可動域の変化を検討すると、自動屈曲と自動外転は術前と比べ術後9ヵ月以降に有意な改善を示し、自動外旋は術後3ヵ月以降に有意な改善を示した。また、外転筋力は術後6ヵ月以降に有意な改善を認めた。

  (一社)中部日本整形外科災害外科学会, Sep. 2013, 中部日本整形外科災害外科学会雑誌, 56(5) (5), 1085 - 1086, Japanese

  [Refereed]


• 手根管症候群に対するpain visionを用いた上肢機能障害評価の試み

  Kokubu Takeshi, Mifune Yutaka, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Sep. 2013, 中部日本整形外科災害外科学会雑誌, 56(秋季学会) (秋季学会), 121 - 121, Japanese


• トリアムシノロンアセトニドの腱細胞脆弱化は適正な使用量、投与間隔で回避できる

  Kokubu Takeshi, Mifune Yutaka, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2013, 日本整形外科学会雑誌, 87(8) (8), S1494 - S1494, Japanese


• Volar dislocation of index and middle finger carpometacarpal joints: a case report

  Inui A, Kokubu Takeshi, Mifune Yutaka

  Aug. 2013, J Hand Surg Eur Vol, English

  [Refereed]

  Scientific journal


• ヒト腱板由来細胞シートを用いたラット腱板断裂修復術の検討

  Mifune Yutaka, Kokubu Takeshi, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2013, 日本整形外科学会雑誌, 87(8) (8), S1495 - S1495, Japanese


• 鏡視下スーチャーブリッジ腱板修復術後の腱板再断裂症例の検討

  Kokubu Takeshi, Mifune Yutaka, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4) (4), 444 - 444, Japanese


• トリアムシノロンアセトニドの抗炎症作用に対するPRP併用の影響

  Kokubu Takeshi, Mifune Yutaka, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4) (4), 349 - 349, Japanese


• ヒト腱板由来細胞に対するトリアムシノロンアセトニドの影響 投与量、投与間隔の検討

  Kokubu Takeshi, Mifune Yutaka, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(3) (3), S687 - S687, Japanese


• 糖化最終生成物が腱板由来細胞に与える影響に関する検討

  Mifune Yutaka, Kokubu Takeshi, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(2) (2), S405 - S405, Japanese


• スーチャーブリッジ法による鏡視下腱板修復術後の腱板再断裂の評価

  Kokubu Takeshi, Mifune Yutaka, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(3) (3), S811 - S811, Japanese


• Stimulation of superficial zone protein accumulation by hedgehog and Wnt signaling in surface zone bovine articular chondrocytes.

  Takashi Iwakura, Atsuyuki Inui, A Hari Reddi

  OBJECTIVE: To determine the roles of the hedgehog and Wnt signaling pathways in accumulation of superficial zone protein (SZP) in surface zone articular chondrocytes. METHODS: Explant cultures of disks of surface zone cartilage or isolated chondrocytes from the surface zone of articular cartilage of bovine stifle joints were cultured in serum-free chemically defined medium. Accumulation of SZP in the culture medium, in response to hedgehog proteins (sonic hedgehog [SHH] and Indian hedgehog [IHH]), Wnt proteins (Wnt-3a, Wnt-5a, and Wnt-11), agonists of the Wnt/β-catenin pathway (glycogen synthase kinase 3β [GSK-3β] inhibitors), and antagonists of the Wnt/β-catenin pathway, was investigated. The interaction between transforming growth factor β1 (TGFβ1) and hedgehog proteins or antagonists of the Wnt/β-catenin pathway was also investigated. RESULTS: Hedgehog proteins stimulated SZP accumulation. Activation of the Wnt/β-catenin pathway by Wnt-3a and GSK-3β inhibitors led to inhibition of SZP accumulation; however, Wnt-5a and Wnt-11 had no influence on SZP accumulation. Conversely, antagonists of the Wnt/β-catenin pathway stimulated SZP accumulation. In addition, there were combinatorial effects of TGFβ1 and hedgehog proteins or antagonists of the Wnt/β-catenin pathway on SZP accumulation. CONCLUSION: SHH and IHH signaling has a stimulatory effect on SZP accumulation in surface zone cartilage and isolated articular chondrocytes. These findings provide insight into the regulatory mechanisms of articular cartilage homeostasis and maintenance by morphogens.

  Feb. 2013, Arthritis and rheumatism, 65(2) (2), 408 - 17, English, International magazine

  Scientific journal


• Regeneration of rotator cuff tear using electrospun poly(d,l-Lactide-Co-Glycolide) scaffolds in a rabbit model.

  Atsuyuki Inui, Takeshi Kokubu, Yutaka Mifune, Ryosuke Sakata, Hanako Nishimoto, Kotaro Nishida, Toshihiro Akisue, Ryosuke Kuroda, Makoto Satake, Hiroaki Kaneko, Hiroyuki Fujioka

  Dec. 2012, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 28(12) (12), 1790 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Human stem cells and articular cartilage regeneration.

  Atsuyuki Inui, Takashi Iwakura, A Hari Reddi

  The regeneration of articular cartilage damaged due to trauma and posttraumatic osteoarthritis is an unmet medical need. Current approaches to regeneration and tissue engineering of articular cartilage include the use of chondrocytes, stem cells, scaffolds and signals, including morphogens and growth factors. Stem cells, as a source of cells for articular cartilage regeneration, are a critical factor for articular cartilage regeneration. This is because articular cartilage tissue has a low cell turnover and does not heal spontaneously. Adult stem cells have been isolated from various tissues, such as bone marrow, adipose, synovial tissue, muscle and periosteum. Signals of the transforming growth factor beta superfamily play critical roles in chondrogenesis. However, adult stem cells derived from various tissues tend to differ in their chondrogenic potential. Pluripotent stem cells have unlimited proliferative capacity compared to adult stem cells. Chondrogenesis from embryonic stem (ES) cells has been studied for more than a decade. However, establishment of ES cells requires embryos and leads to ethical issues for clinical applications. Induced pluripotent stem (iPS) cells are generated by cellular reprogramming of adult cells by transcription factors. Although iPS cells have chondrogenic potential, optimization, generation and differentiation toward articular chondrocytes are currently under intense investigation.

  Nov. 2012, Cells, 1(4) (4), 994 - 1009, English, International magazine

  Scientific journal


• Ligament regeneration using an absorbable stent-shaped poly-L-lactic acid scaffold in a rabbit model.

  Hanako Nishimoto, Takeshi Kokubu, Atsuyuki Inui, Yutaka Mifune, Kotaro Nishida, Hiroyuki Fujioka, Kumiko Yokota, Chiaki Hiwa, Masahiro Kurosaka

  PURPOSE: Ligaments are frequently damaged in sports activities and trauma, and severe ligament injury can lead to joint instability and osteoarthritis. In this study, we aimed to regenerate the medial collateral ligament (MCL) using an absorbable stent-shaped poly-L-lactic acid (PLLA) scaffold in a rabbit model to examine the biocompatibility and mechanical properties. METHODS: Twenty-three Japanese white rabbits were used in this study. MCL defects were surgically created in the knee joints and then reconstructed using stent-shaped PLLA scaffolds. As controls, flexor digitorum longus (FDL) tendons were implanted into the contralateral knees. Seven rabbits were sacrificed at three time points, conducted four, eight and 16 weeks after the operation. The regenerated tissues were histologically evaluated using fibre alignment scoring, morphology of fibroblast scoring and immunohistochemical analysis of types I and III collagen. The regenerated tissues were also biomechanically evaluated by measuring the ultimate failure load and stiffness. RESULTS: At four weeks post-operation, spindle-shaped cells were observed on the inside of the scaffolds. At eight weeks, maturation of the regenerated tissues and collagen fibre alignment parallel to the ligaments was observed. At 16 weeks, the fibre alignment had become denser. The fibre alignment and morphology of fibroblast scores significantly increased in a time-dependent manner. Expression of type I collagen was more strongly observed in the scaffold group at eight and 16 weeks post-operation than at four weeks. Type III collagen was also observed at four, eight and 16 weeks post-operation. A thin layer of fibrocartilage was observed at the ligament-bone junction at eight and 16 weeks. The ultimate failure load of the scaffold group was 46.7 ± 20.7 N, 66.5 ± 11.0 N and 74.3 ± 11.5 N at four, eight and 16 weeks post-operation, respectively. There was no statistical difference between the normal MCL and the scaffold group at 16 weeks post-operation. CONCLUSIONS: The stent-shaped PLLA scaffold allowed for MCL regeneration with type I collagen expression and fibrocartilage formation and resulted in sufficient mechanical function.

  Nov. 2012, International orthopaedics, 36(11) (11), 2379 - 86, English, International magazine

  [Refereed]

  Scientific journal


• Reconstruction of the elbow joint with extracorporeal irradiated bone graft associated with low intensity pulsed ultrasound in malignant soft tissue tumor.

  Kenta Kishimoto, Hiroyuki Fujioka, Toshihiro Akisue, Takeshi Kokubu, Hitomi Hara, Issei Nagura, Atsuyuki Inui, Narikazu Toyokawa, Minoru Doita, Masahiro Kurosaka

  Apr. 2012, Journal of shoulder and elbow surgery, 21(4) (4), e1-4 - E4, English, International magazine

  [Refereed]

  Scientific journal


• Localization of vascular endothelial growth factor during the early stages of osteochondral regeneration using a bioabsorbable synthetic polymer scaffold.

  Ryosuke Sakata, Takeshi Kokubu, Issei Nagura, Narikazu Toyokawa, Atsuyuki Inui, Hiroyuki Fujioka, Masahiro Kurosaka

  Feb. 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 30(2) (2), 252 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Application of layered poly (L-lactic acid) cell free scaffold in a rabbit rotator cuff defect model.

  Atsuyuki Inui, Takeshi Kokubu, Hiroyuki Fujioka, Issei Nagura, Ryosuke Sakata, Hanako Nishimoto, Masaru Kotera, Takashi Nishino, Masahiro Kurosaka

  BACKGROUND: This study evaluated the application of a layered cell free poly (L-lactic acid) (PLLA) scaffold to regenerate an infraspinatus tendon defect in a rabbit model. We hypothesized that PLLA scaffold without cultivated cells would lead to regeneration of tissue with mechanical properties similar to reattached infraspinatus without tendon defects. METHODS: Layered PLLA fabric with a smooth surface on one side and a pile-finished surface on the other side was used. Novel form of layered PLLA scaffold was created by superimposing 2 PLLA fabrics. Defects of the infraspinatus tendon were created in 32 rabbits and the PLLA scaffolds were transplanted, four rabbits were used as normal control. Contralateral infraspinatus tendons were reattached to humeral head without scaffold implantation. Histological and mechanical evaluations were performed at 4, 8, and 16 weeks after operation. RESULTS: At 4 weeks postoperatively, cell migration was observed in the interstice of the PLLA fibers. Regenerated tissue was directly connected to the bone composed mainly of type III collagen, at 16 weeks postoperatively. The ultimate failure load increased in a time-dependent manner and no statistical difference was seen between normal infraspinatus tendon and scaffold group at 8 and 16 weeks postoperatively. There were no differences between scaffold group and reattach group at each time of point. The stiffness did not improve significantly in both groups. CONCLUSIONS: A novel form of layered PLLA scaffold has the potential to induce cell migration into the scaffold and to bridge the tendon defect with mechanical properties similar to reattached infraspinatus tendon model.

  Dec. 2011, Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT, 3, 29 - 29, English, International magazine

  [Refereed]

  Scientific journal


• 股関節ブロックを併用した大腿骨頸部骨折に対する局所麻酔下骨接合術

  乾 淳幸, 高橋 完靖, 新倉 隆宏, 李 相亮, 大江 啓介, 黒坂 昌弘

  (一社)日本骨折治療学会, Dec. 2011, 骨折, 33(4) (4), 889 - 891, Japanese

  [Refereed]


• Pyogenic granuloma in a finger of a rheumatoid arthritis patient.

  Atsuyuki Inui, Hiroyuki Fujioka, Toshihiro Akisue, Takeshi Kokubu, Masahiro Kurosaka

  Pyogenic granuloma is benign soft tissue tumor which mainly occurs in gingiva, lips, tongue and finger. We report the patient of pyogenic granuloma in the distal phalanx of the index finger of the rheumatoid patient. The tumor enlarged rapidly and surgical excision was performed. Pathological examination showed lobular hyperplasia of capillary vessels and the expression of vascular endothelial growth factor at capillary vessels in inside of tumor.

  Jan. 2011, The Kobe journal of medical sciences, 56(4) (4), E162-4, English, Domestic magazine

  Scientific journal


• Potency of double-layered poly L-lactic acid scaffold in tissue engineering of tendon tissue.

  Atsuyuki Inui, Takeshi Kokubu, Takeshi Makino, Issei Nagura, Narikazu Toyokawa, Ryosuke Sakata, Masaru Kotera, Takashi Nishino, Hiroyuki Fujioka, Masahiro Kurosaka

  A successful scaffold for use in tendon tissue engineering requires a high affinity for living organisms and the ability to maintain its mechanical strength until maturation of the regenerated tissue. We compared two types of poly(L-lactic acid) (PLLA) scaffolds for use in tendon regeneration, a plain-woven PLLA fabric (fabric P) with a smooth surface only and a double layered PLLA fabric (fabric D) with a smooth surface on one side and a rough (pile-finished) surface on the other side. These two types of fabric were implanted into the back muscles of rabbits and evaluated at three and six weeks after implantation. Histological examination showed collagen tissues were highly regenerated on the rough surface of fabric D. On the other hand, liner cell attachment was seen in the smooth surface of fabric P and fabric D. The total DNA amount was significantly higher in fabric D. Additionally, mechanical examination showed fabric P had lost its mechanical strength by six weeks after implantation, while the strength of fabric D was maintained. Fabric D had more cell migration on one side and less cell adhesion on the other side and maintained its initial strength. Thus, a novel form of double-layered PLLA fabric has the potential to be used as a scaffold in tendon regeneration.

  Dec. 2010, International orthopaedics, 34(8) (8), 1327 - 32, English, International magazine

  [Refereed]

  Scientific journal


• Electrospun synthetic polymer scaffold for cartilage repair without cultured cells in an animal model.

  Narikazu Toyokawa, Hiroyuki Fujioka, Takeshi Kokubu, Issei Nagura, Atsuyuki Inui, Ryosuke Sakata, Makoto Satake, Hiroaki Kaneko, Masahiro Kurosaka

  PURPOSE: The purpose of our study was to explore the possibility that an electrospun bioabsorbable scaffold could be used in the treatment of a full-thickness articular defect without the addition of exogenous cells in a rabbit model. METHODS: Two types of poly(D,L-lactide-co-glycolide) (PLG) scaffolds, a solid cylindrical type and a cannulated tubular type, were made with the electrospinning method. Osteochondral defects, 5 mm in diameter and 5 mm in depth, made on the femoral condyles of rabbits were filled with these scaffolds, and the repair process was investigated histologically. RESULTS: In the groups in which the defect was filled with the scaffold, fibrous tissue at the articular surface of the scaffold was observed at postoperative week 2. Thereafter cartilage at the articular surface and bone at the subchondral zone were regenerated, and the repaired cartilage was maintained through postoperative week 24. By contrast, the untreated defect was filled with hematoma at postoperative week 2; thereafter regenerated cartilage and bone were observed. However, the surface of the articular cartilage was not regular, and regenerated cartilage was not well organized. The histologic scores of the groups in which the defect was filled with cannulated tubular electrospun PLG scaffolds were significantly higher than those of the untreated defect group at postoperative weeks 12 and 24 (P < .01). CONCLUSIONS: The electrospun PLG scaffold could repair a 5-mm osteochondral defect created in the rabbit model without exogenous cultured cells. CLINICAL RELEVANCE: The electrospun PLG scaffold could repair full-thickness osteochondral defects. The cannulated type of PLG scaffold has the possibility to lead not only to good regeneration of cartilage but also to easy transplantation by use of a guidewire through the cannulas in the scaffold.

  Mar. 2010, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 26(3) (3), 375 - 83, English, International magazine

  Scientific journal


• Stress fracture of the fifth metatarsal bone as a late complication of total knee arthroplasty.

  Hiroyuki Fujioka, Takeshi Kokubu, Takeshi Makino, Hiroaki Hirata, Issei Nagura, Atsuyuki Inui, Juichi Tanaka, Shinichi Yoshiya, Masahiro Kurosaka

  A 64-year-old man had undergone a right total knee arthroplasty (TKA) as treatment for osteoarthritis of the knee. Six months after the TKA, the patient sustained a stress fracture of the left fifth metatarsal bone, which was a contralateral side of the TKA, without any apparent trauma or cause. The fracture was treated with internal fixation using a screw and low-intensity pulsed ultrasound treatment was added. During two-year followup after internal fixation of the fifth metatarsal fracture, he had no complaints in the knee or foot. The patient felt anxiety of breakage or loosening of the implant of TKA and the patient had been walking bearing mainly on his left leg and foot which was a contralateral side of the TKA. The cause of the stress fracture of the fifth metatarsal bone was speculated to be excessive stress of weight bearing to the left foot during walking. The physicians should be aware of the risk of stress fracture of the fifth metatarsal bone as one of a rare late complication associated with TKA. It is very important to educate the patients, explaining the risk of breakage or loosening of the implant of TKA and instructing the adequate physical and mental benefits of walking.

  Feb. 2010, The Kobe journal of medical sciences, 55(4) (4), E93-7, English, Domestic magazine

  Scientific journal


• Treatment of subungual glomus tumor.

  Hiroyuki Fujioka, Takeshi Kokubu, Toshihiro Akisue, Issei Nagura, Narikazu Toyokawa, Atsuyuki Inui, Ryosuke Sakata, Masahiro Kurosaka

  We report four cases of chronic obscure pain in the finger tips. High-resolution magnetic resonance imaging (HR-MRI) findings helped diagnose the existence of a mass at the subungual area and all patients were treated with excision and biopsy. The pathological diagnosis was glomus tumor. HR-MRI is useful in the diagnosis of patients with subungual glomus tumor.

  Jun. 2009, The Kobe journal of medical sciences, 55(1) (1), E1-4, English, Domestic magazine

  Scientific journal


• The effect of porosity and mechanical property of a synthetic polymer scaffold on repair of osteochondral defects.

  Risa Ikeda, Hiroyuki Fujioka, Issei Nagura, Takeshi Kokubu, Narikazu Toyokawa, Atsuyuki Inui, Takeshi Makino, Hiroaki Kaneko, Minoru Doita, Masahiro Kurosaka

  We have made three types of poly (DL-lactide-co-glycolide) (PLG) scaffolds (porosity: scaffold I 80 +/- 0.9%, II 85 +/- 0.8%, III 92 +/- 0.7%; compression module determined with 10% strain: scaffold I 0.26 MPa, II 0.091 MPa, III 0.0047 MPa). Osteochondral defects made in the femoral condyle of rabbits were treated with these scaffolds and the possibilities of cartilage repair were investigated histologically. At post-operative weeks 6 and 12, histological scores in the groups of scaffolds II and III were significantly higher than the score in the group of scaffold I. Scaffolds II and III, which have higher porosity than scaffold I, allow better migration of bone marrow cells and better replacement of the scaffold with bone and cartilage than scaffold I. This study suggests that higher porosity allowing bone marrow cells to migrate to the scaffold is important in repairing osteochondral defects.

  Jun. 2009, International orthopaedics, 33(3) (3), 821 - 8, English, International magazine

  Scientific journal


• Anterosuperior dislocation of the shoulder joint in an older patient with Parkinson's disease.

  Tokio Matsuzaki, Takeshi Kokubu, Issei Nagura, Narikazu Toyokawa, Atsuyuki Inui, Hiroyuki Fujioka, Minoru Doita, Masahiro Kurosaka

  An 83-year-old woman, subsequently diagnosed with Parkinson's disease, fell on her right shoulder. Radiographs showed the humeral head dislocated anterosuperiorly. The supraspinatus tendon was massively disrupted and judged irreparable. The subscapularis tendon was repaired, however re-dislocation of the humeral head was confirmed after the surgery but further treatment was rejected as she was almost pain free and had a low activity level. The patient was followed up for one year after surgery and her shoulder became almost pain-free, but range of motion with active elevation was limited. In such cases a goal of absence or reduction of pain rather than real repair might be considered appropriate.

  Mar. 2009, The Kobe journal of medical sciences, 54(5) (5), E237-40, English, Domestic magazine

  Scientific journal


• Shoulder fracture dislocation associated with axillary artery injury: A case report

  Atsuyuki Inui, Takeshi Kokubu, Hiroyuki Fujioka, Narikazu Toyokawa, Keitaro Nakagiri, Minoru Doita, Masahiro Kurosaka

  Mar. 2009, Journal of Shoulder and Elbow Surgery, 18(2) (2), e14 - e16, English

  Scientific journal


• Stress fracture of the first rib in a high school weight lifter.

  Hiroyuki Fujioka, Takeshi Kokubu, Takeshi Makino, Issei Nagura, Narikazu Toyokawa, Atsuyuki Inui, Ryosuke Sakata, Masahiro Kurosaka

  A 17-year-old boy, who played a weight lifting in high school, sustained stress fracture of the first rib without any causes. We successfully treated first rib stress fracture with limitation of using the upper extremity and with using low-intensity pulsed ultrasound. Key pointsStress fracture of the first rib in a weight lifter was successfully treated with limitation of sports activity and with LIPUS treatment.

  2009, Journal of sports science & medicine, 8(2) (2), 308 - 10, English, International magazine

  Scientific journal

• 上腕骨遠位部骨折術後に生じた尺骨神経麻痺に対して腱移行および神経移行を行った1例

  伊達知宏, 乾淳幸, 美舩泰, 西本華子, 吉川智也, 黒田良祐

  2022, 中部日本整形外科災害外科学会雑誌, 65


• 腱細胞における高血糖ストレスに対するQuercetinの抗酸化作用

  吉川 智也, 美舩 泰, 乾 淳幸, 山裏 耕平, 篠原 一生, 国分 毅

  (一社)日本肩関節学会, Nov. 2021, 肩関節, 45(3) (3), 438 - 438, Japanese


• ラット腱板修復モデルにおけるティラピア由来うろこコラーゲンの有効性の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 吉川 智也, 篠原 一生, 国分 毅

  (一社)日本肩関節学会, Nov. 2021, 肩関節, 45(3) (3), 439 - 439, Japanese


• 腱板断裂を伴う関節拘縮に対する徒手的受動術の成否に関する因子の検討

  美舩 泰, 乾 淳幸, 山裏 耕平, 吉川 智也, 篠原 一生, 国分 毅

  (一社)日本肩関節学会, Nov. 2021, 肩関節, 45(3) (3), 460 - 460, Japanese


• 小中学生野球肘検診における肘離断性骨軟骨炎予測因子の検討

  吉川 智也, 美舩 泰, 乾 淳幸, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2021, 日本臨床スポーツ医学会誌, 29(4) (4), S236 - S236, Japanese


• 深層学習による肘OCDエコー画像の病変検出モデルの作成

  乾 淳幸, 美舩 泰, 吉川 智也, 黒田 良祐, 古川 隆浩

  (一社)日本臨床スポーツ医学会, Oct. 2021, 日本臨床スポーツ医学会誌, 29(4) (4), S237 - S237, Japanese


• 機械学習モデルによる既存椎体骨折の有無の診断の試み

  乾 淳幸, 西本 華子, 美舩 泰, 新倉 隆宏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2021, 日本骨粗鬆症学会雑誌, 7(Suppl.1) (Suppl.1), 268 - 268, Japanese


• コロナ禍における骨粗鬆症患者の骨密度の推移

  西本 華子, 乾 淳幸, 美舩 泰, 丸野 文雅, 金谷 貴子, 新倉 隆宏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2021, 日本骨粗鬆症学会雑誌, 7(Suppl.1) (Suppl.1), 348 - 348, Japanese


• リバース人工肩関節置換術術後1年の可動域良好群と不良群での術前因子の比較

  加藤 達雄, 美舩 泰, 乾 淳幸, 西本 華子, 向原 伸太郎, 国分 毅

  (一社)中部日本整形外科災害外科学会, Sep. 2021, 中部日本整形外科災害外科学会雑誌, 64(秋季学会) (秋季学会), 129 - 129, Japanese


• 糖尿病を伴う肩腱板断裂における肩関節内組織別AGEs(advanced glycation end-products)沈着量とその影響に関する検討

  篠原 一生, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1503 - S1503, Japanese


• 術後の腱板修復に影響を与える因子 ラット腱板修復モデルにおけるティラピア由来うろこコラーゲンの有効性の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 向原 伸太郎, 吉川 智也, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1592 - S1592, Japanese


• AIモデルによる肘関節離断性骨軟骨炎の超音波画像診断

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1644 - S1644, Japanese


• 人工知能モデルによる関節リウマチへの生物学的製剤治療効果の予測

  前田 俊恒, 林 申也, 乾 淳幸, 黒田 雄一, 中野 直樹, 西本 華子, 橋本 慎吾, 美舩 泰, 松本 知之, 松原 司, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1732 - S1732, Japanese


• 糖尿病患者における糖化・酸化ストレスが腱板に及ぼす影響

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1741 - S1741, Japanese


• 糖尿病の有無による腱板断裂患者の関節包へのAGEs(advanced glycation end-products)沈着量の検討

  篠原 一生, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1742 - S1742, Japanese


• 三次元電磁気センサを使用した遠位橈尺関節不安定性の定量化

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 吉川 智也, 篠原 一生, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1744 - S1744, Japanese


• Deep learningを用いたTFCC損傷のエコー画像診断

  篠原 一生, 乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1745 - S1745, Japanese


• 粒子画像流速測定法によるTFCC(triangular fibrocartilage complex)損傷の超音波断層像の評価

  篠原 一生, 乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1746 - S1746, Japanese


• 糖尿病性腱障害に対するquercetin投与効果の検討

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1829 - S1829, Japanese


• リバース型人工肩関節置換術における上腕骨外方化の効果

  国分 毅, 美舩 泰, 乾 淳幸

  (一社)日本肩関節学会, Aug. 2021, 肩関節, 45(1) (1), 163 - 166, Japanese


• 超音波による軟部組織動態の定量化 粒子画像流速測定法による手根管症候群の神経の動態解析

  乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒澤 堯, 黒田 良祐

  日本整形外科超音波学会, Jul. 2021, 日本整形外科超音波学会学術集会プログラム・抄録集, 32回, 74 - 74, Japanese


• ディープラーニングによる手根管症候群の超音波画像診断

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  日本整形外科超音波学会, Jul. 2021, 日本整形外科超音波学会学術集会プログラム・抄録集, 32回, 144 - 144, Japanese


• ディープラーニングによる手根管症候群の超音波画像診断の試み

  乾 淳幸, 西本 華子, 美舩 泰, 山裏 耕平, 向原 伸太郎, 吉川 智也, 篠原 一生

  日本末梢神経学会, Jun. 2021, 末梢神経, 32(1) (1), 112 - 117, Japanese


• 高齢女性におけるQOL評価別身体能力

  西本 華子, 乾 淳幸, 美舩 泰, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2021, The Japanese Journal of Rehabilitation Medicine, 58(特別号) (特別号), 1 - 7, Japanese


• 腱板断裂を伴う関節拘縮に対する全身麻酔下徒手的受動術の成否に関する因子の検討

  美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2021, The Japanese Journal of Rehabilitation Medicine, 58(特別号) (特別号), 3 - 3, Japanese


• 手根管症候群の超音波画像に対するディープラーニング

  乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎

  (一社)日本手外科学会, Apr. 2021, 日本手外科学会雑誌, 37(6) (6), 857 - 860, Japanese


• 深層学習の手法による肘管症候群のエコー画像診断

  乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 篠原 一生, 黒田 良祐

  (一社)日本手外科学会, Apr. 2021, 日本手外科学会雑誌, 38(1) (1), PD6 - 5, Japanese


• 三次元電磁気センサを使用した遠位橈尺関節不安定性の定量化

  向原 伸太郎, 乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 吉川 智也, 篠原 一生, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2021, 日本手外科学会雑誌, 38(1) (1), O2 - 03, Japanese


• 超音波断層像を用いた三角繊維軟骨複合体の動態解析

  篠原 一生, 乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本手外科学会, Apr. 2021, 日本手外科学会雑誌, 38(1) (1), O2 - 10, Japanese


• 腱細胞における高血糖誘導酸化ストレスに対するQuercetin投与効果の検討

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 黒田 良祐

  (一社)日本手外科学会, Apr. 2021, 日本手外科学会雑誌, 38(1) (1), O3 - 01, Japanese


• 超音波検査による母指球筋の筋厚と筋面積による評価

  名倉 一成, 金谷 貴子, 原田 義文, 高瀬 史明, 乾 淳幸, 美舩 泰

  (一社)日本手外科学会, Apr. 2021, 日本手外科学会雑誌, 38(1) (1), O23 - 33, Japanese


• 手指外傷におけるインドシアニングリーン(ICG)蛍光造影の有用性の検討

  大崎 健夫, 乾 淳幸, 野村 正, 橋川 和信, 寺師 浩人

  (一社)日本手外科学会, Apr. 2021, 日本手外科学会雑誌, 38(1) (1), O46 - 04, Japanese


• ディープラーニングによるエコー画像での正中神経の位置検出

  乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 篠原 一生, 黒田 良祐

  (一社)日本手外科学会, Apr. 2021, 日本手外科学会雑誌, 38(1) (1), O46 - 07, Japanese


• ラット腱板修復モデルにおけるティラピア由来うろこコラーゲンの有効性の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 向原 伸太郎, 吉川 智也, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S122 - S122, Japanese


• 機械学習による骨粗鬆症外来受診患者の骨密度予測

  乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 篠原 一生, 楊 鴻生, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S476 - S476, Japanese


• ウェアラブルセンサで測定した投球肘ストレスと超音波剪断波エラストグラフィで評価した前腕回内屈筋群の組織弾性との相関の検討

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S520 - S520, Japanese


• 肩甲部に発生したガングリオンに対して関節鏡視下手術を行った2例

  名倉 一成, 高瀬 史明, 原田 義文, 乾 淳幸, 美舩 泰, 黒田 良祐

  症例1は38歳男で、職業は理容師であった。当科受診の約2ヵ月前に誘因なく右肩甲部に痛みと痺れ感が出現した。症状が改善しないため近医を受診し、MRIで異常を指摘され当科に紹介された。症例2は26歳男で、職業は自動車製造業であった。当科受診の約3ヵ月前に誘因なく右肩関節に痛みが出現し、増強したため受診した。両例ともMRIで棘窩切痕部に腫瘤性病変を認め、棘窩切痕部に発生したガングリオンによる肩甲上神経麻痺と診断した。関節鏡視下手術を行い、術中所見として両例とも上方関節唇の損傷を認めたが、腫瘤との交通性は認めなかった。アプローチ方法は両例とも肩峰下滑液包側から肩甲棘に向かってアプローチし、同定した基部のガングリオンを掻爬した後にアンカーを用いて関節唇修復を行い、痛みは消失した。

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2021, JOSKAS, 46(1) (1), 24 - 25, Japanese


• ディープラーニングによる肘管症候群のエコー画像診断

  乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S865 - S865, Japanese


• 超音波断層像を用いた三角線維軟骨複合体の動態解析

  篠原 一生, 乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S880 - S880, Japanese


• 腱細胞における高血糖誘導酸化ストレスに対するquercetinの抗酸化作用の検討

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S883 - S883, Japanese


• 高血糖誘導酸化ストレスを与えた腱細胞に対するDHEAの効果

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 吉川 智也, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S884 - S884, Japanese


• 上腕三頭筋膜による外側側副靱帯再建を行った肘関節後外側回旋不安定症の一例

  中谷 英巴, 美舩 泰, 乾 淳幸, 西本 華子, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2021, 中部日本整形外科災害外科学会雑誌, 64(春季学会) (春季学会), 163 - 163, Japanese


• Double LCP platingによる手関節固定術の治療経験

  若松 亮太, 乾 淳幸, 美舩 泰, 原 仁美, 西本 華子, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2021, 中部日本整形外科災害外科学会雑誌, 64(春季学会) (春季学会), 168 - 168, Japanese


• 超音波検査による手根管開放術後の母指球筋萎縮改善の評価

  名倉 一成, 金谷 貴子, 原田 義文, 高瀬 史明, 乾 淳幸, 美舩 泰

  (一社)日本手外科学会, Jan. 2021, 日本手外科学会雑誌, 37(3) (3), 268 - 270, Japanese


• コラゲナーゼ注射療法における皮膚裂傷発生の検討

  原田 義文, 金谷 貴子, 高瀬 史明, 乾 淳幸, 美舩 泰, 名倉 一成

  (一社)日本手外科学会, Jan. 2021, 日本手外科学会雑誌, 37(3) (3), 373 - 376, Japanese


• 神経・筋超音波の臨床における進歩 末梢神経に対するエコーガイド下インターベンション

  乾 淳幸

  日本末梢神経学会, Dec. 2020, 末梢神経, 31(2) (2), 244 - 246, Japanese


• ディープラーニングによる手根管症候群の超音波画像診断の試み

  乾 淳幸, 西本 華子, 美舩 泰, 山裏 耕平, 向原 伸太郎, 吉川 智也, 篠原 一生, 黒田 良祐

  日本末梢神経学会, Dec. 2020, 末梢神経, 31(2) (2), 279 - 279, Japanese


• 超音波検査とM波による手根管開放術後の母指球筋萎縮改善の評価

  名倉 一成, 金谷 貴子, 原田 義文, 高瀬 史明, 乾 淳幸, 美舩 泰

  日本末梢神経学会, Dec. 2020, 末梢神経, 31(2) (2), 341 - 342, Japanese


• 終末糖化産物に対するアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 山裏 耕平, 吉川 智也

  (一社)日本肩関節学会, Nov. 2020, 肩関節, 44(3) (3), 494 - 494, Japanese


• 良好な腱板修復により大・広範囲腱板断裂の筋萎縮は改善するか?

  国分 毅, 美舩 泰, 乾 淳幸

  (一社)日本肩関節学会, Nov. 2020, 肩関節, 44(3) (3), 505 - 505, Japanese


• 腱板断裂での偽性麻痺と三角筋の複合筋活動電位の相関性

  名倉 一成, 原田 義文, 美舩 泰, 乾 淳幸

  (一社)日本肩関節学会, Nov. 2020, 肩関節, 44(2) (2), 366 - 368, Japanese


• リバース型人工肩関節置換術における肩甲下筋腱修復が与える影響

  国分 毅, 美舩 泰, 乾 淳幸

  (一社)日本肩関節学会, Nov. 2020, 肩関節, 44(2) (2), 418 - 420, Japanese


• 高齢者の肘関節脱臼に対してテープ付きアンカーを用いて靱帯修復を行った1例

  元野 紘平, 乾 淳幸, 美舩 泰, 福井 友章, 新倉 隆宏, 黒田 良祐

  84歳女性。歩行中、転倒にて受傷した。X線およびCT所見より肘関節後方脱臼に橈骨頭骨折、尺骨鈎状突起骨折を合併した損傷と診断され、非観血的脱臼整復と外固定が行なわれた。しかし、整復後も不安定性が強く、脱臼を繰り返したため、受傷14日にテープ付きアンカーを用いた靱帯修復術を施行した。更に後療法として、術後は2週間にわたりシーネ装着下で自動屈曲運動を中心に可動域訓練を開始し、その後、シーネ除去下での自動・他動可動域訓練に移行した。目下、術後6ヵ月経過で肘関節は伸展-30°、屈曲130°であり、不安定性はみられていない。

  (一社)中部日本整形外科災害外科学会, Nov. 2020, 中部日本整形外科災害外科学会雑誌, 63(6) (6), 899 - 900, Japanese


• 肩関節拘縮に対する徒手的受動術の成否に関する因子の検討

  美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 篠原 一生, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 172 - 172, Japanese


• リバース型人工肩関節置換術の術後成績 Inlay型とonlay型の比較

  国分 毅, 美舩 泰, 乾 淳幸

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 276 - 276, Japanese


• ラット腱板修復モデルにおけるうろこコラーゲンの有効性の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 吉川 智也, 篠原 一生, 国分 毅

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 293 - 293, Japanese


• 腱細胞における高血糖ストレスに対するQuercetinの抗酸化作用

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 293 - 293, Japanese


• NMNの腱炎に対する抗炎症・酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 吉川 智也, 篠原 一生, 国分 毅

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 294 - 294, Japanese


• 腱板断裂における偽性麻痺と三角筋の複合筋活動電位の相関性

  名倉 一成, 原田 義文, 高瀬 史明, 乾 淳幸, 美舩 泰

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 300 - 300, Japanese


• 上腕骨遠位coronal shear fractureの治療成績

  向原 伸太郎, 美舩 泰, 乾 淳幸, 黒田 司, 脇 貴洋, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 112 - 112, Japanese


• 高齢女性変形性膝関節症患者の膝蓋骨周囲軟部組織に対する筋膜リリースが膝関節屈曲可動域と膝蓋下脂肪体の厚みに及ぼす即時効果の検討

  伊佐次 優一, 乾 淳幸, 佐藤 優, 廣瀬 健太, 山田 拓実

  (一社)理学療法科学学会, Oct. 2020, 理学療法科学, 35(5) (5), 679 - 683, Japanese


• 肩関節拘縮に対する徒手的受動術の成否に関する因子の検討

  美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 篠原 一生, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 172 - 172, Japanese


• リバース型人工肩関節置換術の術後成績 Inlay型とonlay型の比較

  国分 毅, 美舩 泰, 乾 淳幸

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 276 - 276, Japanese


• ラット腱板修復モデルにおけるうろこコラーゲンの有効性の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 吉川 智也, 篠原 一生, 国分 毅

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 293 - 293, Japanese


• 腱細胞における高血糖ストレスに対するQuercetinの抗酸化作用

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 293 - 293, Japanese


• NMNの腱炎に対する抗炎症・酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 吉川 智也, 篠原 一生, 国分 毅

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 294 - 294, Japanese


• 腱板断裂における偽性麻痺と三角筋の複合筋活動電位の相関性

  名倉 一成, 原田 義文, 高瀬 史明, 乾 淳幸, 美舩 泰

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 300 - 300, Japanese


• 骨粗鬆症外来受診患者にたいする機械学習による骨密度予測

  乾 淳幸, 西本 華子, 美舩 泰, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2020, 日本骨粗鬆症学会雑誌, 6(Suppl.1) (Suppl.1), 244 - 244, Japanese


• Trabecular Bone Score(TBS)は治療の効果判定に有用か

  西本 華子, 乾 淳幸, 美舩 泰, 新倉 隆宏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2020, 日本骨粗鬆症学会雑誌, 6(Suppl.1) (Suppl.1), 254 - 254, Japanese


• 糖尿病性腱障害モデルに対するアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1680 - S1680, Japanese


• 老化制御因子NMN(nicotinamide mononucleotide)の腱炎に対する抗炎症・酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1746 - S1746, Japanese


• 高血糖誘導酸化ストレスを与えた腱細胞に対するDHEAの効果

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1747 - S1747, Japanese


• 高血糖負荷による酸化ストレスを与えた腱細胞に対するquercetinの抗酸化作用の検討

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1758 - S1758, Japanese


• ウェアラブルセンサで測定した投球肘ストレスと超音波剪断波エラストグラフィで評価した前腕回内屈筋の組織弾性との相関

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1899 - S1899, Japanese


• 三次元電磁気センサを使用した遠位橈尺関節不安定性の定量評価法

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 吉川 智也, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1903 - S1903, Japanese


• ラット腱板修復モデルにおけるティラピア由来うろこコラーゲンの有効性の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1927 - S1927, Japanese


• 化膿性肩関節炎の治療経験

  吉川 智也, 美舩 泰, 乾 淳幸, 黒澤 尭, 山裏 耕平, 国分 毅

  (一社)日本肩関節学会, Sep. 2020, 肩関節, 44(1) (1), 175 - 178, Japanese


• 骨粗鬆症外来における機械学習を用いた骨密度予測

  乾 淳幸, 西本 華子, 美舩 泰, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Jul. 2020, 中部日本整形外科災害外科学会雑誌, 63(4) (4), 631 - 632, Japanese


• 三次元電磁気センサを使用した遠位橈尺関節不安定性の定量評価法の開発

  向原 伸太郎, 乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 吉川 智也, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O2 - 2, Japanese


• 粒子画像流速測定法による正中神経のエコー画像解析

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O3 - 4, Japanese


• 老化制御因子NMN(Nicotinamide Mononucleotide)の腱炎に対する抗炎症・酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O9 - 2, Japanese


• コラゲナーゼ注射療法における皮膚裂傷発生の検討

  原田 義文, 金谷 貴子, 高瀬 史明, 乾 淳幸, 美舩 泰, 名倉 一成

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O36 - 2, Japanese


• 手術を必要とした手指関節脱臼の治療経験

  国分 毅, 乾 淳幸, 美舩 泰, 筒井 美緒, 黒田 司

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), P10 - 4, Japanese


• 超音波検査による手根管開放術後の母指球筋萎縮改善の評価

  名倉 一成, 金谷 貴子, 原田 義文, 高瀬 史明, 乾 淳幸, 美舩 泰

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O48 - 3, Japanese


• 手根管症候群の超音波画像に対するディープラーニング

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O62 - 1, Japanese


• 大広範囲腱板断裂に対する大腿筋膜補強を併用した鏡視下腱板修復術

  国分 毅, 竹森 俊幸, 美舩 泰, 乾 淳幸, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 90 - 90, Japanese


• 骨粗鬆症外来における機械学習を用いた骨密度予測

  乾 淳幸, 西本 華子, 美舩 泰, 新倉 隆宏, 楊 鴻生, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 150 - 150, Japanese


• 高齢者肘関節脱臼に対してテープ付きアンカーを用いた靱帯修復を行なった一例

  元野 紘平, 乾 淳幸, 美舩 泰, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 206 - 206, Japanese


• STT(scaphotrapezial trapezoidal)関節症に対してMini-TightRopeを用いたSuspensionplastyを行った2例

  美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 36(6) (6), 941 - 944, Japanese


• コラゲナーゼ注射療法における伸展操作時の皮膚裂傷と超音波検査所見との関係

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 36(6) (6), 1036 - 1038, Japanese


• デュプイトラン拘縮 Dupuytren拘縮のコラゲナーゼ注射療法におけるSTチューブ長選択について

  金谷 貴子, 名倉 一成, 原田 義文, 美舩 泰, 乾 淳幸

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 36(6) (6), 1078 - 1078, Japanese


• デュプイトラン拘縮 コラゲナーゼ注射療法における伸展操作時の皮膚裂傷発生についての検討

  名倉 一成, 金谷 貴子, 原田 義文, 美舩 泰, 乾 淳幸

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 36(6) (6), 1079 - 1079, Japanese


• 膝・肩関節 Unstable painful shoulder(UPS)に対して鏡視下手術を行った1例

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  関西関節鏡・膝研究会, Mar. 2020, 関西関節鏡・膝研究会プログラム・演題抄録, 32回, 25 - 25, Japanese


• 超音波検査を用いた手根管症候群における母指球筋の術後1年での変化

  名倉 一成, 原田 義文, 乾 淳幸

  日本整形外科超音波学会, Mar. 2020, 日本整形外科超音波学会会誌, 31(1) (1), 68 - 71, Japanese


• 機械学習による骨粗鬆症外来での骨折リスク予測の試み

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S642 - S642, Japanese


• Shear wave elastographyを用いた投球動作による前腕屈筋群の組織弾性変化についての検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 国分 毅, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S702 - S702, Japanese


• 超音波検査を用いた手根管症候群における母指球筋の術後変化

  名倉 一成, 金谷 貴子, 原田 義文, 高瀬 史明, 乾 淳幸, 美舩 泰, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S822 - S822, Japanese


• 高血糖誘導酸化ストレスを与えた腱細胞に対するDHEAの効果

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S836 - S836, Japanese


• 老化制御因子NMN(nicotinamide mononucleotide)の腱炎に対する抗炎症・酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S837 - S837, Japanese


• ディープラーニングによる手根管症候群のエコー画像診断

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 吉川 智也, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1075 - S1075, Japanese


• 治療薬別のtrabecular bone score(TBS)値およびbone mineral density(BMD)値の2年間の推移

  西本 華子, 乾 淳幸, 美舩 泰, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 吉川 智也, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1146 - S1146, Japanese


• プロ野球投手におけるglenohumeral internal rotation deficit(GIRD)に関連する因子の検討

  美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 吉川 智也, 国分 毅, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1258 - S1258, Japanese


• 右肘関節開放脱臼骨折に合併したMycobacterium fortuitum感染症の1例

  村尾 仁美, 乾 淳幸, 西本 華子, 美舩 泰, 黒田 良祐

  52歳女性。自動車事故で右肘関節開放脱臼骨折を受傷し、前医で観血的骨接合術と靱帯修復術を受けた。その後、再脱臼を繰り返し、当科紹介受診となった。受傷後2ヵ月に大腿筋膜をグラフトとした右肘内外側側副靱帯再建術を施行したが、術後34日に創部より排膿を認めた。血液検査で炎症反応の上昇を認め、一般細菌培養は全て陰性であった。 セファゾリンとST合剤の経口投与を開始し、外側の病巣掻爬術と橈骨インプラントの抜釘術を施行した。再建靱帯が融解しており、これを除去した。内側に炎症の波及はなく、内側の靱帯は温存した。術後、抗酸菌培養からMycobacterium fortuitumが検出された。セフメタゾールとアミカシンの点滴を開始し、創部の腫脹が速やかに消退した。点滴開始後14日にモキシフロキサシンとST合剤の経口投与に変更し、術後30日にCRPが陰性化した。約6ヵ月間、抗生剤を継続し、以後感染の再発を認めていない。

  (一社)中部日本整形外科災害外科学会, Jan. 2020, 中部日本整形外科災害外科学会雑誌, 63(1) (1), 121 - 122, Japanese


• 末梢神経のエコーについて

  乾 淳幸

  日本末梢神経学会, Dec. 2019, 末梢神経, 30(2) (2), 220 - 221, Japanese


• 手根管症候群手術症例における超音波検査による母指球筋萎縮とM波の評価

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰

  日本末梢神経学会, Dec. 2019, 末梢神経, 30(2) (2), 277 - 277, Japanese


• 神経障害性疼痛に対する末梢神経ハイドロリリースの治療効果

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  日本末梢神経学会, Dec. 2019, 末梢神経, 30(2) (2), 284 - 284, Japanese


• 肘頭裂離骨折を伴った上腕三頭筋腱皮下断裂の治療経験

  国分 毅, 美舩 泰, 乾 淳幸, 片岡 武史, 黒澤 尭

  日本肘関節学会, Dec. 2019, 日本肘関節学会雑誌, 26(2) (2), 120 - 122, Japanese


• 化膿性肘関節炎後の関節症性変化に対して人工関節置換術を行った1例

  名倉 一成, 原田 義文, 乾 淳幸, 美舩 泰

  日本肘関節学会, Dec. 2019, 日本肘関節学会雑誌, 26(2) (2), 239 - 241, Japanese


• プロ野球投手におけるGlenohumeral internal rotation deficit(GIRD)の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 片岡 武史, 黒澤 堯, 国分 毅

  (一社)日本肩関節学会, Nov. 2019, 肩関節, 43(4) (4), 925 - 925, Japanese


• ラット腱板断裂モデルに対するbFGFとPRP同時投与の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 黒澤 尭, 山裏 耕平, 国分 毅

  (一社)日本肩関節学会, Nov. 2019, 肩関節, 43(4) (4), 934 - 934, Japanese


• 腱板再断裂症例の術前危険因子

  国分 毅, 美舩 泰, 乾 淳幸

  (一社)日本肩関節学会, Nov. 2019, 肩関節, 43(4) (4), 938 - 938, Japanese


• ばね指治療にみられるPIP/IP関節屈曲拘縮に関与する因子の検討

  原田 義文, 金谷 貴子, 名倉 一成, 乾 淳幸, 美舩 泰, 国分 毅

  (一社)日本手外科学会, Nov. 2019, 日本手外科学会雑誌, 36(2) (2), 40 - 42, Japanese


• 超音波検査を用いた手根管症候群における母指球筋萎縮の質的評価

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰

  (一社)日本手外科学会, Nov. 2019, 日本手外科学会雑誌, 36(2) (2), 72 - 74, Japanese


• リバース型人工肩関節置換術における肩甲下筋腱修復が与える影響

  国分 毅, 美舩 泰, 乾 淳幸

  (一社)日本肩関節学会, Oct. 2019, 日本肩関節学会抄録集, 46回, 128 - 128, Japanese


• プロ野球投手におけるGIRDに関連する因子の検討

  美舩 泰, 乾 淳幸, 山裏 耕平, 西本 華子, 片岡 武史, 黒澤 堯, 向原 伸太郎, 吉川 智也, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2019, 日本肩関節学会抄録集, 46回, 131 - 131, Japanese


• 腱板断裂での偽性麻痺と三角筋の複合筋活動電位の相関性

  名倉 一成, 原田 義文, 乾 淳幸, 美舩 泰

  (一社)日本肩関節学会, Oct. 2019, 日本肩関節学会抄録集, 46回, 151 - 151, Japanese


• 終末糖化産物に対するアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2019, 日本肩関節学会抄録集, 46回, 288 - 288, Japanese


• 化膿性肩関節炎の治療経験

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2019, 日本肩関節学会抄録集, 46回, 295 - 295, Japanese


• 良好な腱板修復により大・広範囲腱板断裂の筋萎縮は改善するか?

  国分 毅, 美舩 泰, 乾 淳幸

  (一社)日本肩関節学会, Oct. 2019, 日本肩関節学会抄録集, 46回, 340 - 340, Japanese


• プロ野球投手の肩関節コンディションと股関節可動域スコアの関係

  美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 吉川 智也, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2019, 日本肩関節学会抄録集, 46回, 360 - 360, Japanese


• 腱細胞における高血糖ストレスに対するNMNの抗酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 黒澤 堯, 向原 伸太郎, 吉川 智也, 国分 毅

  (一社)日本肩関節学会, Oct. 2019, 日本肩関節学会抄録集, 46回, 374 - 374, Japanese


• 化膿性肩関節炎に対する治療経験

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(秋季学会) (秋季学会), 147 - 147, Japanese


• 肘関節開放脱臼骨折に合併したMycobacterium fortuitum感染症の一例

  村尾 仁美, 乾 淳幸, 美舩 泰, 西本 華子, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(秋季学会) (秋季学会), 149 - 149, Japanese


• Vocabulary 終末糖化産物

  黒澤 尭, 美舩 泰, 乾 淳幸, 黒田 良祐

  (株)南江堂, Sep. 2019, 整形外科, 70(10) (10), 1104 - 1104, Japanese


• 腱板断裂における三角筋複合活動電位と術前肩関節機能の相関

  名倉 一成, 原田 義文, 美舩 泰, 乾 淳幸

  (一社)日本肩関節学会, Sep. 2019, 肩関節, 43(2) (2), 552 - 554, Japanese


• 肩腱板由来細胞における終末糖化産物による酸化ストレスに対するアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1694 - S1694, Japanese


• 高血糖誘導酸化ストレスを与えた腱細胞に対するDHEAの効果

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 尭, 山裏 耕平, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1698 - S1698, Japanese


• 糖尿病性腱障害モデルに対するアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1699 - S1699, Japanese


• 高血糖ストレスモデルを用いたラット腱細胞における老化制御因子NMN(nicotinamide mononucleotide)の抗酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 尭, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1699 - S1699, Japanese


• 三次元電磁気センサを使用した前腕回旋運動の定量的評価の試み

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 尭, 山裏 耕平, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1769 - S1769, Japanese


• 骨格筋不動化による筋萎縮・脂肪細胞浸潤と慢性炎症の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 国分 毅, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1867 - S1867, Japanese


• 治療薬別のTrabecular Bone Score(TBS)値およびBone Mineral Density(BMD)値の2年間の推移 TBSは治療の効果判定に有用か

  西本 華子, 乾 淳幸, 美舩 泰, 今堀 正也, 新倉 隆宏, 鷲見 正敏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2019, 日本骨粗鬆症学会雑誌, 5(Suppl.1) (Suppl.1), 283 - 283, Japanese


• Vocabulary 終末糖化産物

  黒澤 尭, 美舩 泰, 乾 淳幸, 黒田 良祐

  (株)南江堂, Sep. 2019, 整形外科, 70(10) (10), 1104 - 1104, Japanese


• 三次元電磁気センサを使用した前腕回旋運動の定量的評価の試み

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 尭, 山裏 耕平, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1769 - S1769, Japanese


• 高血糖誘導酸化ストレスを与えた腱細胞に対するDHEAの効果

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 尭, 山裏 耕平, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1698 - S1698, Japanese


• 糖尿病性腱障害モデルに対するアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1699 - S1699, Japanese


• 高血糖ストレスモデルを用いたラット腱細胞における老化制御因子NMN(nicotinamide mononucleotide)の抗酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 尭, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1699 - S1699, Japanese


• 骨格筋不動化による筋萎縮・脂肪細胞浸潤と慢性炎症の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 国分 毅, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1867 - S1867, Japanese


• 肩腱板由来細胞における終末糖化産物による酸化ストレスに対するアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1694 - S1694, Japanese


• 変形性膝関節症患者における膝蓋骨周囲への対する筋膜リリースの治療効果 膝関節屈曲可動域・膝蓋下脂肪体の肥厚に着目して

  伊佐次 優一, 乾 淳幸, 竹井 仁

  日本整形外科超音波学会, Jul. 2019, 日本整形外科超音波学会学術集会プログラム・抄録集, 31回, 68 - 68, Japanese


• 神経障害性疼痛に対するエコーガイド下ハイドロリリースの治療効果

  乾 淳幸, 黒澤 尭

  日本整形外科超音波学会, Jul. 2019, 日本整形外科超音波学会学術集会プログラム・抄録集, 31回, 81 - 81, Japanese


• 超音波検査を用いた手根管症候群における母指球筋の経時的変化

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰

  日本整形外科超音波学会, Jul. 2019, 日本整形外科超音波学会学術集会プログラム・抄録集, 31回, 85 - 85, Japanese


• 母指MP関節過伸展を伴う背側不安定症に対して掌側板修復術を施行した2例

  田中 悟, 乾 淳幸, 西本 華子, 美舩 泰, 黒田 良祐

  症例1は22歳女性で、数年前から仕事でよく手を使うようになってから左母指MP関節の背側不安定性を自覚し、疼痛も伴ったため当科を受診した。単純レントゲンストレス撮影では両母指MP関節の背側亜脱臼を認め、掌側板を中手骨頭に縫縮し、開放していたA1 pulleyも補強として同部位に一緒に縫合した。術後27ヵ月時点で不安定性や疼痛はなく、母指MP関節可動域は屈曲50°、伸展0°となり、レントゲン画像やエコーではエンドポイントがみられた。症例2は48歳男性で、2年前に工事現場の振動工具で右母指を過伸展受傷した際に亜脱臼感を自覚し、その後も不安定性が続いていたため当科を受診した。手術は症例1と同様の手技で行い、開放したA1 pulleyごと掌側板をsuture anchorを用いて中手骨頭に縫縮した。術後10ヵ月時点で不安定性や疼痛はなく、母指MP関節可動域は伸展0°でエコーではエンドポイントを認めた。

  (一社)中部日本整形外科災害外科学会, Jul. 2019, 中部日本整形外科災害外科学会雑誌, 62(4) (4), 747 - 748, Japanese


• 超音波検査を用いた手根管症候群における母指球筋の経時的変化

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰

  日本整形外科超音波学会, Jul. 2019, 日本整形外科超音波学会学術集会プログラム・抄録集, 31回, 85 - 85, Japanese


• 上腕骨遠位coronal shear fractureの治療成績

  向原 伸太郎, 乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 黒田 司, 脇 貴洋, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S201 - S201, Japanese


• 投球動作における肩関節周囲筋組織弾性の経時的変化

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 堯, 向原 伸太郎, 国分 毅, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 333 - 333, Japanese


• プロ野球投手における肩関節コンディションと股関節可動域制限スコアの関係(Hip stiffness score has correlations with range of motion and muscle power of throwing shoulder in professional baseball pitchers)

  美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 国分 毅, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 347 - 347, English


• 高齢者女性におけるロコモスキャンと運動能力の比較

  西本 華子, 乾 淳幸, 美舩 泰, 片岡 武史, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 350 - 350, Japanese


• 若年者の外傷性膝関節脱臼に伴う総腓骨神経麻痺に対して神経移植術を施行した1例

  田中 悟, 乾 淳幸, 向原 伸太郎, 山裏 耕平, 黒澤 堯, 片岡 武史, 西本 華子, 美舩 泰, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 552 - 552, Japanese


• モーションキャプチャセンサによる、手指運動角度の測定

  乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 2 - 6, Japanese


• 投球動作における肩関節周囲筋組織弾性の経時的変化

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 堯, 向原 伸太郎, 国分 毅, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 333 - 333, Japanese


• プロ野球投手における肩関節コンディションと股関節可動域制限スコアの関係(Hip stiffness score has correlations with range of motion and muscle power of throwing shoulder in professional baseball pitchers)

  美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 国分 毅, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 347 - 347, English


• 高齢者女性におけるロコモスキャンと運動能力の比較

  西本 華子, 乾 淳幸, 美舩 泰, 片岡 武史, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 350 - 350, Japanese


• 若年者の外傷性膝関節脱臼に伴う総腓骨神経麻痺に対して神経移植術を施行した1例

  田中 悟, 乾 淳幸, 向原 伸太郎, 山裏 耕平, 黒澤 堯, 片岡 武史, 西本 華子, 美舩 泰, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 552 - 552, Japanese


• ラット腱板修復術モデルに対するbFGFおよびPRP同時投与の有効性の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 酒井 良忠, 秋末 敏宏, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 2 - 12, Japanese


• モーションキャプチャセンサによる、手指運動角度の測定

  乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 2 - P1, Japanese


• 尺側手根中手関節脱臼骨折の治療経験

  国分 毅, 筒井 美緒, 乾 淳幸, 美舩 泰, 黒田 司

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 35(6) (6), 1205 - 1208, Japanese


• 三次元電磁気センサーを用いた肘関節可動域の定量評価法の開発

  山裏 耕平, 乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 向原 伸太郎, 国分 毅, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), O2 - 5, Japanese


• 超音波検査を用いた手根管症候群における母指球筋萎縮の質的評価

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), O30 - 2, Japanese


• ジャイロセンサを利用した、ウエラブル上肢運動モニタリングシステムの開発

  乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), P1 - 2, Japanese


• モーションキャプチャーセンサを使用した手指外転角度の測定

  乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), P1 - 3, Japanese


• 三次元電磁気センサを使用した前腕回旋運動の定量的評価の試み

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), P1 - 5, Japanese


• STT(scaphotrapezial trapezoidal)関節症に対してMini-TightRopeを用いたSuspensionplastyを行った2例

  美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 国分 毅

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), P31 - 2, Japanese


• 剪断波超音波エラストグラフィを用いた野球選手における肘内側側副靱帯の組織弾性測定

  黒澤 尭, 乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 山裏 耕平, 向原 伸太郎, 国分 毅

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), BP1 - 5, Japanese


• 神経損傷後の骨格筋不動化による筋萎縮・脂肪細胞浸潤と脂肪組織炎症の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 国分 毅, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), BP2 - 6, Japanese


• ばね指治療にみられるPIP/IP関節屈曲拘縮に関与する因子について

  原田 義文, 金谷 貴子, 名倉 一成, 乾 淳幸, 美舩 泰, 国分 毅

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), O40 - 5, Japanese


• Dupuytren拘縮に対するコラゲナーゼ注入後の組織内拡散についての検討

  金谷 貴子, 名倉 一成, 原田 義文, 吉川 智也, 美舩 泰, 乾 淳幸

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), O45 - 2, Japanese


• コラゲナーゼ注射療法における伸展操作時の皮膚裂傷と超音波検査所見との関係

  名倉 一成, 金谷 貴子, 原田 義文, 美舩 泰, 乾 淳幸

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), O45 - 3, Japanese


• Dupuytren拘縮のコラゲナーゼ注射療法に対するSTチューブ長選択の実際

  金谷 貴子, 名倉 一成, 原田 義文, 吉川 智也, 美舩 泰, 乾 淳幸

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), O45 - 6, Japanese


• 三次元電磁気センサーを用いた肘関節可動域の定量評価法の開発

  山裏 耕平, 乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 向原 伸太郎, 国分 毅, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), O2 - 5, Japanese


• 超音波検査を用いた手根管症候群における母指球筋萎縮の質的評価

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), O30 - 2, Japanese


• ジャイロセンサを利用した、ウエラブル上肢運動モニタリングシステムの開発

  乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), P1 - 2, Japanese


• モーションキャプチャーセンサを使用した手指外転角度の測定

  乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), P1 - 3, Japanese


• 三次元電磁気センサを使用した前腕回旋運動の定量的評価の試み

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), P1 - 5, Japanese


• STT(scaphotrapezial trapezoidal)関節症に対してMini-TightRopeを用いたSuspensionplastyを行った2例

  美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 国分 毅

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), P31 - 2, Japanese


• 剪断波超音波エラストグラフィを用いた野球選手における肘内側側副靱帯の組織弾性測定

  黒澤 尭, 乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 山裏 耕平, 向原 伸太郎, 国分 毅

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), BP1 - 5, Japanese


• 神経損傷後の骨格筋不動化による筋萎縮・脂肪細胞浸潤と脂肪組織炎症の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 国分 毅, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), BP2 - 6, Japanese


• ばね指治療にみられるPIP/IP関節屈曲拘縮に関与する因子について

  原田 義文, 金谷 貴子, 名倉 一成, 乾 淳幸, 美舩 泰, 国分 毅

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), O40 - 5, Japanese


• Dupuytren拘縮に対するコラゲナーゼ注入後の組織内拡散についての検討

  金谷 貴子, 名倉 一成, 原田 義文, 吉川 智也, 美舩 泰, 乾 淳幸

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), O45 - 2, Japanese


• コラゲナーゼ注射療法における伸展操作時の皮膚裂傷と超音波検査所見との関係

  名倉 一成, 金谷 貴子, 原田 義文, 美舩 泰, 乾 淳幸

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), O45 - 3, Japanese


• Dupuytren拘縮のコラゲナーゼ注射療法に対するSTチューブ長選択の実際

  金谷 貴子, 名倉 一成, 原田 義文, 吉川 智也, 美舩 泰, 乾 淳幸

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), O45 - 6, Japanese


• 尺側手根中手関節脱臼骨折の治療経験

  国分 毅, 筒井 美緒, 乾 淳幸, 美舩 泰, 黒田 司

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 35(6) (6), 1205 - 1208, Japanese


• 手根管症候群における超音波検査を用いた母指球筋の質的評価

  名倉 一成, 金谷 貴子, 原田 義文, 鷲見 正敏, 乾 淳幸, 美舩 泰, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S254 - S254, Japanese


• 医学部5年次bed side learningにおけるシリコン製スポンジを用いた腱縫合実習

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 尭, 片岡 武史, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S297 - S297, Japanese


• 超音波エラストグラフィー法にて測定した、肩甲帯の疼痛に対する筋膜間ブロックの治療効果

  乾 淳幸, 黒澤 堯

  肩甲帯の疼痛に対してエコーガイド下にハイドロリリースを行った患者14例を対象に、ストレインエラストグラフィ法で僧帽筋の筋硬度(Stain ratio)を測定し、治療前後で比較した。疼痛スコア(NRS)で評価した治療効果は治療前7.3±1.4から治療後4.2±1.9と有意に低下した。Strain ratioは治療前2.9±2.1から治療後5.2±3.7と有意に上昇した。

  日本整形外科超音波学会, Mar. 2019, 日本整形外科超音波学会会誌, 30(1) (1), 74 - 77, Japanese


• 超音波検査を用いた手根管症候群における母指球筋の筋輝度の評価

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸

  手根管症候群(CTS)は進行し重症化すると母指球筋萎縮をきたす。著者等は母指球筋の評価方法として、超音波診断装置で短母指外転筋(APB)と母指対立筋(OPP)の筋厚を測定する方法について報告してきた。今回、CTSと診断され手術を受けた症例69手を対象に、APB・OPPの筋輝度をImageJで評価し、電気生理学的重症度(Stage)別で比較した。結果、重症度が高くなるほど筋輝度はAPB・OPPとも高値を示し、特にStage 4・5では有意な高値を示した。

  日本整形外科超音波学会, Mar. 2019, 日本整形外科超音波学会会誌, 30(1) (1), 84 - 87, Japanese


• ラット腱板断裂に対するbFGFおよびPRP含浸ゼラチンハイドロゲルシート移植術の有効性の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (一社)日本移植学会, Mar. 2019, 移植, 53(6) (6), 389 - 389, Japanese


• 母指MP関節過伸展を伴う背側不安定症に対して掌側板修復術を施行した2例

  田中 悟, 乾 淳幸, 西本 華子, 美舩 泰, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(春季学会) (春季学会), 159 - 159, Japanese


• 肩腱板不全損傷に対する鏡視下腱板修復術の検討

  国分 毅, 美舩 泰, 乾 淳幸, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(春季学会) (春季学会), 188 - 188, Japanese


• 神経損傷後の骨格筋萎縮・脂肪細胞浸潤と脂肪組織炎症の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 堯, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(春季学会) (春季学会), 246 - 246, Japanese


• 大・広範囲腱板断裂の腱板筋萎縮は腱板修復により改善するのか

  国分 毅, 美舩 泰, 乾 淳幸, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(3) (3), S786 - S786, Japanese


• ラット腱板修復モデルにおけるbFGFおよびPRP含侵ゼラチンハイドロゲルシート移植術の有効性の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 国分 毅, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(3) (3), S1111 - S1111, Japanese


• 高血糖ストレスモデルを用いたラット腱細胞における老化制御因子NMNの抗炎症・酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 尭, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(3) (3), S1257 - S1257, Japanese


• 手根管症候群における超音波検査を用いた母指球筋の質的評価

  名倉 一成, 金谷 貴子, 原田 義文, 鷲見 正敏, 乾 淳幸, 美舩 泰, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S254 - S254, Japanese


• 医学部5年次bed side learningにおけるシリコン製スポンジを用いた腱縫合実習

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 尭, 片岡 武史, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S297 - S297, Japanese


• 骨釘による指関節固定を行った化膿性DIP関節炎の2例

  中林 大治, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒田 良祐

  骨釘を用いて関節固定を行った化膿性指関節炎2例を呈示した。症例1は30歳男性で、魚の背びれが右中指に刺さったことを契機に発症した。症例2は71歳男性で、右中指爪周囲炎の保存加療中に発症した。患者が多数回の手術を拒否したため一期的手術を選択し、病巣を掻把後に肘頭から採取した骨釘による関節固定を行った。症例1はZiehl-Neelsen染色の結果、非結核性抗酸菌感染の診断で6ヵ月間のCAM、EB、RFPの内服を行った。症例2は培養検査よりMSSAを検出したため12週間のCEX内服を行った。その後、2例ともに感染の再燃は無く、骨癒合が得られた。

  (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(2) (2), 225 - 226, Japanese


• 肘頭裂離骨折を伴った上腕三頭筋腱皮下断裂の治療経験

  国分 毅, 美舩 泰, 乾 淳幸, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎

  日本肘関節学会, Feb. 2019, 日本肘関節学会雑誌, 26(1) (1), S50 - S50, Japanese


• 化膿性肘関節炎後の関節症性変化に対して人工関節置換術を行った1例

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰

  日本肘関節学会, Feb. 2019, 日本肘関節学会雑誌, 26(1) (1), S103 - S103, Japanese


• 上顆炎 高血糖ストレスモデルを用いたラット腱細胞におけるNMN(Nicotinamide Mononucleotide)の抗酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 片岡 武史, 黒澤 尭, 向原 伸太郎, 国分 毅

  日本肘関節学会, Feb. 2019, 日本肘関節学会雑誌, 26(1) (1), S105 - S105, Japanese


• Shear Wave Elastographyを用いた投球動作による前腕屈筋群の組織弾性変化についての検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 山裏 耕平, 向原 伸太郎, 国分 毅, 黒田 良祐

  日本肘関節学会, Feb. 2019, 日本肘関節学会雑誌, 26(1) (1), S127 - S127, Japanese


• 上腕骨遠位coronal shear fractureの治療成績

  向原 伸太郎, 美舩 泰, 乾 淳幸, 片岡 武史, 黒澤 堯, 山裏 耕平, 国分 毅

  日本肘関節学会, Feb. 2019, 日本肘関節学会雑誌, 26(1) (1), S152 - S152, Japanese


• Shear Wave Elastographyを用いた投球動作による前腕屈筋群の組織弾性変化についての検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 山裏 耕平, 向原 伸太郎, 国分 毅, 黒田 良祐

  日本肘関節学会, Feb. 2019, 日本肘関節学会雑誌, 26(1) (1), S127 - S127, Japanese


• 手根管症候群における超音波検査での母指球筋の筋輝度の評価

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰

  (一社)日本手外科学会, Jan. 2019, 日本手外科学会雑誌, 35(4) (4), 637 - 639, Japanese


• シリコンチューブを用いた注射深度コントロールはコラゲナーゼ注射時の皮膚障害を減少させる

  原田 義文, 金谷 貴子, 名倉 一成, 乾 淳幸, 美舩 泰, 国分 毅

  (一社)日本手外科学会, Dec. 2018, 日本手外科学会雑誌, 35(3) (3), 524 - 527, Japanese


• プロ野球選手の下肢肉離れ 10年間の調査

  国分 毅, 美舩 泰, 乾 淳幸, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Nov. 2018, 日本臨床スポーツ医学会誌, 26(4) (4), S174 - S174, Japanese


• 70歳未満の広範囲腱板断裂に対する大腿筋膜補強による鏡視下修復術

  国分 毅, 美舩 泰, 乾 淳幸, 山裏 耕平, 黒田 良祐

  70歳未満の広範囲腱板断裂症例の術後臨床成績について検討した。2011年以降に当科で鏡視下腱板修復術を施行した症例のうち、腱板断端でフットプリントを覆うことができなかった70歳未満の腱板広範囲断裂13例(男性9例、女性4例、平均63.2歳)を対象とし、single row(SR)法施行群とSR修復部を大腿筋膜で補強する大腿筋膜補強(GA)法施行群に分類した。術前から最終経過観察時のJOAスコア、UCLAスコア、ConstantスコアはGA群もSR群も有意に改善していた。再断裂は術後6ヵ月で撮影したMRIにて、GA群で8例中2例、SR群で5例中4例に認めた。術前後の外転筋力は、GA法は術前2.3kgが最終経過観察時5.5kgに有意に改善したが、SR法では1.5kgが2.9kgと改善するも有意差は認めなかった。最終経過観察時の手術に対する満足度はGA群が5点満点で4.7点、SR群では4.2点で有意差は認めなかったがGA群の方が高値であった。

  (一社)中部日本整形外科災害外科学会, Nov. 2018, 中部日本整形外科災害外科学会雑誌, 61(6) (6), 1215 - 1216, Japanese


• 臨床経験 ST法(Silicone tube法)を用いたDupuytren拘縮に対するコラゲナーゼ注射法におけるチューブ長の選択

  金谷 貴子, 名倉 一成, 原田 義文, 美舩 泰, 乾 淳幸

  (株)医学書院, Oct. 2018, 臨床整形外科, 53(10) (10), 927 - 931, Japanese


• 投球動作による肩関節周囲筋組織弾性の経時的変化

  山裏 耕平, 美舩 泰, 乾 淳幸, 植田 安洋, 片岡 武史, 黒澤 堯, 国分 毅

  (一社)日本肩関節学会, Oct. 2018, 肩関節, 42(4) (4), 813 - 813, Japanese


• CAT・HFTと肩後方筋群の筋厚・弾性率の関係

  美舩 泰, 乾 淳幸, 植田 安洋, 片岡 武史, 黒澤 尭, 山裏 耕平, 国分 毅

  (一社)日本肩関節学会, Oct. 2018, 肩関節, 42(4) (4), 821 - 821, Japanese


• 骨釘による指関節固定を行った化膿性DIP関節炎の2例

  中林 大治, 黒田 良祐, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史

  (一社)中部日本整形外科災害外科学会, Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 138 - 138, Japanese


• プロ野球投手におけるGlenohumeral internal rotation deficit(GIRD)の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 198 - 198, Japanese


• ラット腱板修復モデルに対するゼラチンハイドロゲルシートを用いたbFGFとPRP同時投与の有効性

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 堯, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 257 - 257, Japanese


• 腱板断裂に対する大腿筋膜補強法とスーチャーブリッジ法の比較

  国分 毅, 美舩 泰, 乾 淳幸

  (一社)日本肩関節学会, Sep. 2018, 肩関節, 42(2) (2), 495 - 498, Japanese


• 化膿性肩関節炎に対する治療経験

  名倉 一成, 原田 義文, 乾 淳幸, 美舩 泰

  (一社)日本肩関節学会, Sep. 2018, 肩関節, 42(2) (2), 543 - 547, Japanese


• ラット腱板断裂モデルに対するbFGFとPRP同時投与の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 国分 毅

  (一社)日本肩関節学会, Sep. 2018, 日本肩関節学会抄録集, 45回, 151 - 151, Japanese


• 腱板再断裂症例の術前危険因子

  国分 毅, 美舩 泰, 乾 淳幸, 片岡 武史, 山裏 耕平

  (一社)日本肩関節学会, Sep. 2018, 日本肩関節学会抄録集, 45回, 172 - 172, Japanese


• プロ野球投手におけるGIRDの検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 片岡 武史, 黒澤 堯, 向原 伸太郎, 国分 毅

  (一社)日本肩関節学会, Sep. 2018, 日本肩関節学会抄録集, 45回, 187 - 187, Japanese


• 腱板断裂での三角筋の複合筋活動電位と術前の肩関節機能の相関性

  名倉 一成, 原田 義文, 乾 淳幸, 美舩 泰

  (一社)日本肩関節学会, Sep. 2018, 日本肩関節学会抄録集, 45回, 229 - 229, Japanese


• 野球選手における棘下筋萎縮に関連する因子の検討

  美舩 泰, 乾 淳幸, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 国分 毅

  (一社)日本肩関節学会, Sep. 2018, 日本肩関節学会抄録集, 45回, 258 - 258, Japanese


• 骨粗鬆症患者におけるEQ-5D効用値と身体部位の疼痛スコアの関連

  乾 淳幸, 西本 華子, 美舩 泰, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2018, 日本骨粗鬆症学会雑誌, 4(Suppl.1) (Suppl.1), 280 - 280, Japanese


• ラット腱板修復モデルにおけるゼラチンハイドロゲルシートを用いたbFGFとPRP同時投与の有効性の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 黒澤 尭, 山裏 耕平, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1907 - S1907, Japanese


• アポシニンは肩腱板由来細胞において終末糖化産物による酸化ストレスに対して抑制効果を示す

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 山裏 耕平, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1908 - S1908, Japanese


• 高血糖ストレスモデルを用いたラット腱細胞における老化制御因子NMN(nicotinamide mononucleotide)の抗炎症・酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 尭, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S2037 - S2037, Japanese


• 筋膜リリース・Hydro-releaseを科学する 超音波エラストグラフィー法にて測定した、肩甲帯の疼痛に対する筋膜間ブロックの治療効果

  乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  日本整形外科超音波学会, Jul. 2018, 日本整形外科超音波学会学術集会プログラム・抄録集, 30回, 53 - 53, Japanese


• Shear Wave Elastographyを用いた投球動作による前腕屈筋群の組織弾性変化についての検討

  黒澤 尭, 乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  日本整形外科超音波学会, Jul. 2018, 日本整形外科超音波学会学術集会プログラム・抄録集, 30回, 94 - 94, Japanese


• 超音波検査を用いた手根管症候群における母指球筋の筋輝度の評価

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰

  日本整形外科超音波学会, Jul. 2018, 日本整形外科超音波学会学術集会プログラム・抄録集, 30回, 157 - 157, Japanese


• 若年成人に発生した非定型大腿骨骨折の3例

  李 相亮, 大江 啓介, 福井 友章, 乾 淳幸, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jul. 2018, 骨折, 40(Suppl.) (Suppl.), S495 - S495, Japanese


• 若年成人に発生した非定型大腿骨骨折の3例

  李 相亮, 大江 啓介, 福井 友章, 乾 淳幸, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jul. 2018, 骨折, 40(Suppl.) (Suppl.), S495 - S495, Japanese


• 高齢者女性における下肢筋肉量と筋力・運動能力の比較

  西本 華子, 乾 淳幸, 美舩 泰, 植田 安洋, 片岡 武史, 黒澤 尭, 山裏 耕平, 酒井 良忠, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018, JOSKAS, 43(4) (4), 442 - 442, Japanese


• ラット腱板断裂モデルに対するb-FGFおよびPRP含侵ゼラチンハイドロゲルシート移植術の有効性の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 黒澤 堯, 山裏 耕平, 国分 毅, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018, JOSKAS, 43(4) (4), 492 - 492, Japanese


• プロ野球投手におけるGlenohumeral internal rotation deficit(GIRD)の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 尭, 国分 毅, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018, JOSKAS, 43(4) (4), 659 - 659, Japanese


• 福山型筋ジストロフィーの筋病変に対する超音波を用いた低侵襲評価

  原田 理沙, 池田 真理子, 西本 華子, 井上 美帆, 伊達 安理, 乾 淳幸, 三浦 靖史, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 1 - 2, Japanese


• 老化が腱炎に及ぼす影響の検討

  植田 安洋, 乾 淳幸, 美舩 泰, 片岡 武史, 黒澤 堯, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 1 - 2, Japanese


• Shear Wave Elastographyを用いた野球選手の肘内側側副靱帯の評価

  美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 2 - 1, Japanese


• 低TBS(Trabecular Bone Score)値の症例におけるBMD(Bone Mineral Density)の値による特徴

  西本 華子, 乾 淳幸, 美舩 泰, 井上 美帆, 植田 安洋, 片岡 武史, 原田 理沙, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 2 - 2, Japanese


• 筋膜間ブロックに対する、超音波エラストグラフィー法による治療評価

  乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 堯, 山裏 耕平, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 3 - 5, Japanese


• 超音波検査にて注射至適深度決定後ST法によるコラゲナーゼ注射は皮膚障害を減少させる

  原田 義文, 金谷 貴子, 名倉 一成, 乾 淳幸, 美舩 泰, 国分 毅

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S138 - S138, Japanese


• Dupuytren拘縮に対するSTチューブを用いたコラゲナーゼ注入法におけるチューブ長選択について

  金谷 貴子, 名倉 一成, 原田 義文, 美舩 泰, 乾 淳幸

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S140 - S140, Japanese


• 高血糖ストレスモデルを用いたラット腱細胞におけるアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 山裏 耕平, 黒田 良祐

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S161 - S161, Japanese


• マウスアキレス腱炎における老化の影響の検討

  植田 安洋, 乾 淳幸, 美舩 泰, 国分 毅, 黒田 良祐

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S162 - S162, Japanese


• ロープ状シリコン製スポンジを用いた腱縫合実習

  乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 堯, 山裏 耕平, 黒田 良祐

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S515 - S515, Japanese


• 橈骨遠位端骨折後変形治癒に対する骨移植を用いたOpen Wedge Osteotomyの術後成績

  美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 堯, 山裏 耕平, 黒田 司, 国分 毅, 黒田 良祐

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S565 - S565, Japanese


• 尺側手根中手関節脱臼骨折の治療経験

  国分 毅, 筒井 美緒, 黒田 司, 美舩 泰, 乾 淳幸

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S634 - S634, Japanese


• エコー装置を用いた橈骨神経浅枝・尺骨神経背側枝の観察

  乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 堯, 山裏 耕平, 黒田 良祐

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S659 - S659, Japanese


• 手根管症候群における超音波検査での母指球筋の筋輝度の評価

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S704 - S704, Japanese


• 母指CM関節障害に対するMini-TightRopeを用いたSuspensionplastyの治療成績

  山裏 耕平, 乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 堯, 国分 毅, 黒田 良祐

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S763 - S763, Japanese


• 橈骨遠位端骨折歴のある患者のバランス能力と筋量についての検討

  西本 華子, 乾 淳幸, 植田 安洋, 片岡 武史, 黒澤 堯, 山裏 耕平, 美舩 泰, 黒田 良祐

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S786 - S786, Japanese


• 広範囲腱板断裂に対する大腿筋膜補強による鏡視下修復術

  国分 毅, 美舩 泰, 乾 淳幸, 山裏 耕平, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2018, 中部日本整形外科災害外科学会雑誌, 61(春季学会) (春季学会), 236 - 236, Japanese


• 母指CM関節症に対するMini-TightRopeを用いたThompson変法併用療法の治療成績

  山裏 耕平, 乾 淳幸, 美舩 泰, 西本 華子, 国分 毅, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2018, 中部日本整形外科災害外科学会雑誌, 61(春季学会) (春季学会), 261 - 261, Japanese


• 症候性豆状骨有鉤骨癒合症の1例

  乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2018, 中部日本整形外科災害外科学会雑誌, 61(春季学会) (春季学会), 289 - 289, Japanese


• 手根管症候群手術症例における超音波検査を用いた母指球筋の質的評価

  名倉 一成, 金谷 貴子, 原田 義文, 鷲見 正敏, 乾 淳幸, 美舩 泰, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(2) (2), S164 - S164, Japanese


• 手関節背側部における皮神経のエコー画像解析

  乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 尭, 山裏 耕平, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(2) (2), S168 - S168, Japanese


• 腱板再断裂に対するアプローチ 腱板再断裂症例の検討 術前の危険因子について

  国分 毅, 美舩 泰, 乾 淳幸, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(2) (2), S355 - S355, Japanese


• 低TBS(trabecular bone score)値の症例におけるBMD(bone mineral density)の値による特徴 TBSとBMDが乖離する症例の検討

  西本 華子, 乾 淳幸, 美舩 泰, 植田 安洋, 片岡 武史, 黒澤 尭, 山裏 耕平, 楊 鴻生, 鷲見 正敏, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(3) (3), S840 - S840, Japanese


• 腰椎椎体骨折におけるtrabecular bone scoreとbone mineral densityの比較 TBSの骨折予測因子としての働き

  西本 華子, 乾 淳幸, 美舩 泰, 植田 安洋, 片岡 武史, 黒澤 尭, 山裏 耕平, 楊 鴻生, 鷲見 正敏, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(3) (3), S1096 - S1096, Japanese


• 青年〜中年期における尺骨肘頭骨折に対するプレート固定術の治療成績

  乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 堯, 山裏 耕平, 国分 毅

  日本肘関節学会, Jan. 2018, 日本肘関節学会雑誌, 25(1) (1), S96 - S96, Japanese


• Shear Wave Elastographyを用いた野球選手の肘内側側副靱帯の評価

  美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 堯, 山裏 耕平, 国分 毅

  日本肘関節学会, Jan. 2018, 日本肘関節学会雑誌, 25(1) (1), S120 - S120, Japanese


• 投球動作における肘関節周囲筋群の組織弾性はどのように変化するか?

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 山裏 耕平, 国分 毅, 黒田 良祐

  日本肘関節学会, Jan. 2018, 日本肘関節学会雑誌, 25(1) (1), S121 - S121, Japanese


• 小児経肘頭脱臼骨折の1例

  山裏 耕平, 乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 堯, 国分 毅, 黒田 良祐

  日本肘関節学会, Jan. 2018, 日本肘関節学会雑誌, 25(1) (1), S145 - S145, Japanese


• Dupuytren拘縮へのコラゲナーゼ注射療法における超音波検査法の活用

  原田 義文, 金谷 貴子, 名倉 一成, 乾 淳幸, 美舩 泰

  (一社)日本手外科学会, Jan. 2018, 日本手外科学会雑誌, 34(4) (4), 563 - 565, Japanese


• Dupuytren拘縮に対する注射療法の薬液の拡散の検討

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰

  (一社)日本手外科学会, Dec. 2017, 日本手外科学会雑誌, 34(3) (3), 305 - 307, Japanese


• 手根管症候群手術症例における電気生理学的重症度と超音波検査を用いた母指球筋厚値の比較検討

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰

  (一社)日本手外科学会, Dec. 2017, 日本手外科学会雑誌, 34(3) (3), 326 - 328, Japanese


• 手根管症候群手術症例における超音波検査による母指球筋萎縮とM波の評価

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰

  日本末梢神経学会, Dec. 2017, 末梢神経, 28(2) (2), 308 - 308, Japanese


• プロ野球投手に発症した筋皮神経単独損傷の1例

  山裏 耕平, 国分 毅, 乾 淳幸, 美舩 泰, 黒田 良祐

  日本末梢神経学会, Dec. 2017, 末梢神経, 28(2) (2), 319 - 319, Japanese


• 高周波ブローブエコー装置を用いた、手関節背側部の皮神経の観察

  乾 淳幸, 美舩 泰, 名倉 一成, 金谷 貴子, 国分 毅

  日本末梢神経学会, Dec. 2017, 末梢神経, 28(2) (2), 372 - 372, Japanese


• 老化促進モデルマウスにおける肩腱板付着部(enthesis)の検討

  美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 片岡 武史, 黒澤 尭, 国分 毅

  (一社)日本肩関節学会, Nov. 2017, 肩関節, 41(4) (4), 850 - 850, Japanese


• ウサギ腱板断裂修復モデルを用いた自家大腿筋膜補強術の実験的検討

  片岡 武史, 無藤 智之, 美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 黒澤 尭, 国分 毅

  (一社)日本肩関節学会, Nov. 2017, 肩関節, 41(4) (4), 851 - 851, Japanese


• 大腿筋膜補強による鏡視下腱板修復術術後のMRI変化

  国分 毅, 美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 片岡 武史, 黒澤 尭

  (一社)日本肩関節学会, Nov. 2017, 肩関節, 41(4) (4), 862 - 862, Japanese


• 非定型抗酸菌症性DIP関節炎に対して骨釘による関節固定を行った1例

  片岡 武史, 美舩 泰, 乾 淳幸, 国分 毅

  (一社)日本手外科学会, Nov. 2017, 日本手外科学会雑誌, 34(2) (2), 197 - 198, Japanese


• 化膿性手関節炎に伴う手根骨欠損に対しMasquelet法による再建を行った1例

  乾 淳幸, 美舩 泰, 片岡 武史, 国分 毅

  (一社)日本手外科学会, Nov. 2017, 日本手外科学会雑誌, 34(2) (2), 198 - 198, Japanese


• 非結核性抗酸菌性DIP関節炎に対して骨釘による一期的関節固定を行った1例

  楠瀬 正哉, 美舩 泰, 乾 淳幸, 植田 安洋, 片岡 武史, 黒沢 尭, 山裏 耕平, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Nov. 2017, 中部日本整形外科災害外科学会雑誌, 60(6) (6), 1095 - 1095, Japanese


• 化膿性肩関節炎に対する治療経験

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2017, 日本肩関節学会抄録集, 44回, 195 - 195, Japanese


• 腱板断裂に対する大腿筋膜補強法とスーチャーブリッジ法の比較

  国分 毅, 谷口 充, 美舩 泰, 乾 淳幸

  (一社)日本肩関節学会, Oct. 2017, 日本肩関節学会抄録集, 44回, 249 - 249, Japanese


• 投球動作における肩関節周囲筋組織弾性の経時的変化

  山裏 耕平, 美舩 泰, 乾 淳幸, 黒澤 尭, 片岡 武史, 植田 安洋, 西本 華子, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2017, 日本肩関節学会抄録集, 44回, 326 - 326, Japanese


• CAT・HFTと肩後方筋群の弾性率の関係

  美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 尭, 山裏 耕平, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2017, 日本肩関節学会抄録集, 44回, 330 - 330, Japanese


• 超音波装置を用いた野球選手の肘内側側副靱帯の観察

  乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 尭, 山裏 耕平, 黒田 良祐, 国分 毅

  (一社)日本肩関節学会, Oct. 2017, 日本肩関節学会抄録集, 44回, 331 - 331, Japanese


• 腰椎椎体骨折におけるTrabecular Bone Score(TBS)とBMDの比較 TBSの骨折予測因子としての働き

  西本 華子, 乾 淳幸, 美舩 泰, 楊 鴻生, 酒井 良忠, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2017, 中部日本整形外科災害外科学会雑誌, 60(秋季学会) (秋季学会), 144 - 144, Japanese


• 尺骨肘頭骨折に対するプレート固定術の治療成績

  黒澤 尭, 乾 淳幸, 美舩 泰, 西本 華子, 黒田 司, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2017, 中部日本整形外科災害外科学会雑誌, 60(秋季学会) (秋季学会), 241 - 241, Japanese


• 上腕骨骨幹部骨折に伴う橈骨神経麻痺に超音波検査を行った1例

  名倉 一成, 原田 義文, 乾 淳幸, 美舩 泰, 国分 毅

  (一社)日本肩関節学会, Sep. 2017, 肩関節, 41(2) (2), 620 - 622, Japanese


• 腰椎椎体骨折におけるTrabecular Bone Score(TBS)とBone Mineral Density(BMD)の比較 腰椎椎体骨折におけるTBSの骨折予測因子としての働き

  西本 華子, 乾 淳幸, 美舩 泰, 片岡 武史, 鷲見 正敏, 酒井 良忠, 黒田 良祐, 楊 鴻生

  (一社)日本骨粗鬆症学会, Sep. 2017, 日本骨粗鬆症学会雑誌, 3(Suppl.1) (Suppl.1), 298 - 298, Japanese


• 若年成人に発生した非定型大腿骨骨折の3例

  李 相亮, 新倉 隆宏, 岩倉 崇, 乾 淳幸, 黒田 良祐, 酒井 良忠

  (一社)日本骨粗鬆症学会, Sep. 2017, 日本骨粗鬆症学会雑誌, 3(Suppl.1) (Suppl.1), 347 - 347, Japanese


• 野球選手における肘内側側副靱帯のエコー装置による観察

  乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒田 良祐

  (公社)日本リハビリテーション医学会, Sep. 2017, The Japanese Journal of Rehabilitation Medicine, 54(秋季特別号) (秋季特別号), S257 - S257, Japanese


• 腰椎椎体骨折におけるTrabecular Bone Score(TBS)とBone Mineral Density(BMD)の比較

  西本 華子, 乾 淳幸, 井上 美帆, 植田 安洋, 片岡 武史, 岩本 安理, 美舩 泰, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, Sep. 2017, The Japanese Journal of Rehabilitation Medicine, 54(秋季特別号) (秋季特別号), S257 - S257, Japanese


• 不動化に伴う骨格筋内脂肪細胞浸潤と脂肪組織炎症の検討

  片岡 武史, 乾 淳幸, 美舩 泰, 坂田 亮介, 西本 華子, 高瀬 史明, 植田 安洋, 黒澤 尭, 国分 毅, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1862 - S1862, Japanese


• ウサギ腱板広範囲断裂モデルにおける大腿筋膜移植補強術の修復部の治癒促進効果の検討

  片岡 武史, 国分 毅, 無藤 智之, 美舩 泰, 乾 淳幸, 西本 華子, 高瀬 史明, 植田 安洋, 黒澤 尭, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1866 - S1866, Japanese


• 腱炎における老化の影響の検討

  植田 安洋, 乾 淳幸, 美舩 泰, 国分 毅, 高瀬 史明, 片岡 武史, 黒澤 尭, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1869 - S1869, Japanese


• 高血糖ストレスモデルを用いたラット腱細胞におけるアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 植田 安洋, 片岡 武史, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1870 - S1870, Japanese


• 尺骨近位部骨折に対するプレート固定術の治療成績

  黒澤 尭, 乾 淳幸, 美舩 泰, 高瀬 史明, 植田 安洋, 片岡 武史, 黒田 司, 黒田 良祐

  (一社)日本骨折治療学会, Jul. 2017, 骨折, 39(Suppl.) (Suppl.), S364 - S364, Japanese


• Masquelet法による再建を行った化膿性手関節炎の1例

  乾 淳幸, 美舩 泰, 黒澤 尭, 黒田 良祐

  (一社)日本骨折治療学会, Jul. 2017, 骨折, 39(Suppl.) (Suppl.), S423 - S423, Japanese


• 肩腱板不全断裂に対するアンカーを用いた鏡視下修復術の検討

  国分 毅, 美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 片岡 武史, 黒澤 尭, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 461 - 461, Japanese


• 四肢骨格筋量は高齢者女性QOLに影響を及ぼすのか? 骨格筋指数とEQ-5Dを用いたQOL評価

  西本 華子, 乾 淳幸, 美舩 泰, 片岡 武史, 酒井 良忠, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 601 - 601, Japanese


• 超音波検査による投球障害肩を引き起こす因子の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 高瀬 史明, 植田 安洋, 国分 毅, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 819 - 819, Japanese


• CAT・HFTと肩後方筋群の弾性率の関係

  美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 片岡 武史, 黒澤 尭, 西本 華子, 国分 毅, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 820 - 820, Japanese


• Combined Abduction TestおよびHorizontal Flexion Testと肩後方筋群の弾性率の関係

  美舩 泰, 乾 淳幸, 片岡 武史, 酒井 良忠, 秋末 敏宏, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2017, The Japanese Journal of Rehabilitation Medicine, 54(特別号) (特別号), 1 - 2, Japanese


• 野球選手における超音波検査を用いた筋弾性率と筋厚の評価

  片岡 武史, 美舩 泰, 乾 淳幸, 酒井 良忠, 秋末 敏宏, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2017, The Japanese Journal of Rehabilitation Medicine, 54(特別号) (特別号), 1 - 3, Japanese


• Pain Visionにより測定した手根管症候群手術前後のしびれの変化

  乾 淳幸, 美舩 泰, 片岡 武史, 西本 華子, 国分 毅, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2017, 中部日本整形外科災害外科学会雑誌, 60(春季学会) (春季学会), 183 - 183, Japanese


• 四肢骨格筋量は高齢者QOLに影響を及ぼすのか? 骨格筋指数とEQ-5Dを用いたQOL評価の相関関係

  西本 華子, 乾 淳幸, 楊 鴻生, 酒井 良忠, 鷲見 正敏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2017, 中部日本整形外科災害外科学会雑誌, 60(春季学会) (春季学会), 206 - 206, Japanese


• デュピュイトレン拘縮へのコラゲナーゼ注射におけるエコー検査を用いた工夫

  原田 義文, 金谷 貴子, 名倉 一成, 乾 淳幸, 国分 毅

  (一社)日本手外科学会, Apr. 2017, 日本手外科学会雑誌, 34(1) (1), S203 - S203, Japanese


• Dupuytren拘縮におけるAdvanced glycation end products(AGEs)の関与の検討

  高瀬 史明, 美舩 泰, 乾 淳幸, 植田 安洋, 国分 毅

  (一社)日本手外科学会, Apr. 2017, 日本手外科学会雑誌, 34(1) (1), S209 - S209, Japanese


• デュピトラン拘縮に対する注射療法の薬液の拡散の検討

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 国分 毅

  (一社)日本手外科学会, Apr. 2017, 日本手外科学会雑誌, 34(1) (1), S308 - S308, Japanese


• 手根管症候群のしびれに対するPain Visionによる評価

  乾 淳幸, 美舩 泰, 片岡 武史, 黒澤 尭, 国分 毅

  (一社)日本手外科学会, Apr. 2017, 日本手外科学会雑誌, 34(1) (1), S463 - S463, Japanese


• 老化がアキレス腱縫合術後の腱・筋に及ぼす影響の検討

  植田 安洋, 乾 淳幸, 美舩 泰, 高瀬 史明, 国分 毅

  (一社)日本手外科学会, Apr. 2017, 日本手外科学会雑誌, 34(1) (1), S687 - S687, Japanese


• 上腕二頭筋腱断裂に対してソフトアンカーにて修復を行った1例

  名倉 一成, 乾 淳幸, 美舩 泰, 国分 毅

  50歳男。高所での作業中にバランスを崩して転落しそうになった際、左前腕回外位、左肘屈曲位で体を支えようとして受傷し、左肘に痛みと異音を自覚した。MRIで肘関節前方に水腫と遠位上腕二頭筋腱の断裂を認めたため、遠位上腕二頭筋腱断裂と診断して受傷後約2週で手術を行った。上腕二頭筋腱の遠位のデブリドマン後、橈骨粗面のfoot printを鋭匙にて新鮮化し、Suturefix ultra anchorを2本挿入した。肘関節屈曲60度で上腕二頭筋腱の遠位から中枢へ約2cm程度アンカーからの糸を各々縫合して修復を行った。術後はギプスシーネを約3週間行い、その後は伸展制限付きの装具に変更してリハビリを施行した。術後3ヵ月で仕事に復帰し、術後4ヵ月時点で疼痛なく、術前0度であった伸展の可動域は-5となり、画像所見では修復した遠位上腕二頭筋の連続性を認め、経過良好であった。

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2017, JOSKAS, 42(1) (1), 8 - 9, Japanese


• 腱板大・広範囲断裂に対する大腿筋膜補強法の経時的術後経過

  国分 毅, 美舩 泰, 乾 淳幸, 坂田 亮介, 原田 義文, 高瀬 史明, 植田 安洋, 片岡 武史

  (一社)日本肩関節学会, Mar. 2017, 肩関節, 40(4) (4), 1102 - 1102, Japanese


• 骨吸収マーカーTRACP-5bとhip structural analysisの断面係数は相関するか 病態把握における意義

  西本 華子, 乾 淳幸, 笠原 孝一, 酒井 良忠, 鷲見 正敏, 楊 鴻生, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(2) (2), S51 - S51, Japanese


• 手根管症候群手術症例における超音波検査を用いた母指球筋萎縮の評価

  名倉 一成, 金谷 貴子, 原田 義文, 鷲見 正敏, 乾 淳幸, 美舩 泰, 国分 毅, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(2) (2), S263 - S263, Japanese


• 内反肘に伴う後外側回旋不安定症に対して半拘束型人工肘関節置換術を行った1例

  黒澤 尭, 国分 毅, 美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 片岡 武史

  日本肘関節学会, Jan. 2017, 日本肘関節学会雑誌, 24(1) (1), S67 - S67, Japanese


• 柔道選手に発症した肘頭骨端線閉鎖不全の2例

  美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 片岡 武史, 黒澤 尭, 国分 毅

  日本肘関節学会, Jan. 2017, 日本肘関節学会雑誌, 24(1) (1), S147 - S147, Japanese


• 手根管症候群手術症例における超音波検査による母指球筋萎縮の評価

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰, 国分 毅

  日本末梢神経学会, Dec. 2016, 末梢神経, 27(2) (2), 254 - 254, Japanese


• ハイドロゲルを使用した経皮的炭酸ガス投与はラット末梢神経損傷を改善させる

  乾 淳幸, 西本 華子, 美舩 泰, 国分 毅, 酒井 良忠, 黒田 良祐

  日本末梢神経学会, Dec. 2016, 末梢神経, 27(2) (2), 276 - 276, Japanese


• 手根管症候群手術症例における超音波検査による母指球筋萎縮の客観的評価

  名倉 一成, 金谷 貴子, 乾 淳幸, 美舩 泰, 国分 毅

  (一社)日本手外科学会, Dec. 2016, 日本手外科学会雑誌, 33(3) (3), 219 - 221, Japanese


• 鏡視下烏口鎖骨靱帯再建術後感染にて抜釘を施行した1例

  名倉 一成, 乾 淳幸, 美舩 泰, 国分 毅

  25歳女。交通事故で左肩鎖関節脱臼を受傷した。Rockwood type IIIの新鮮肩鎖関節脱臼と診断し、全身麻酔下に人工靱帯を用いた鏡視下烏口鎖骨靱帯再建術を施行した。術後X線では肩鎖関節脱臼の整復は不十分で、亜脱臼が残存していた。術後1週に39度台の発熱を認め、鎖骨遠位部の術創が離開し浸出液を認めた。デブリドマンを施行したが、創部は治癒せず、術後3ヵ月に抜釘術を施行した。術中所見で鎖骨遠位部のDog Bone Button上の縫合糸周囲に肉芽組織を認め、病理組織学的にリンパ球を主体とした炎症細胞の浸潤を認めた。抜釘後に肩鎖関節の再脱臼を認めたが、創部は治癒した。本例は、アトピー性皮膚炎の既往があり体格が小さく、皮膚状態を考慮し肩鎖関節脱臼を整復する必要があった。しかし、整復不十分で不安定性が残存したためストレスがかかり、創部の離開、治癒不全から感染を引き起こした可能性が考えられた。

  (一社)日本肩関節学会, Oct. 2016, 肩関節, 40(2) (2), 757 - 759, Japanese


• リバース型人工肩関節置換術における関節窩側スクリュー挿入角度の検討

  国分 毅, 美舩 泰, 乾 淳幸, 高瀬 史明, 黒澤 尭, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 252 - 252, Japanese


• 腱板断裂性肩関節症に合併したacromioclavicular joint cystの1例

  黒澤 尭, 国分 毅, 美舩 泰, 乾 淳幸, 植田 安洋, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 310 - 310, Japanese


• 大腿筋膜補強による鏡視下腱板修復術術後のMRI変化

  国分 毅, 美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 片岡 武史, 黒澤 尭

  (一社)日本肩関節学会, Sep. 2016, 日本肩関節学会抄録集, 43回, 119 - 119, Japanese


• リバース型人工肩関節置換術の関節窩側スクリュー挿入角度の検討

  国分 毅, 美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 片岡 武史, 黒澤 尭

  (一社)日本肩関節学会, Sep. 2016, 日本肩関節学会抄録集, 43回, 133 - 133, Japanese


• 上腕骨骨幹部骨折に伴う橈骨神経麻痺に超音波検査を行った1例

  名倉 一成, 原田 義文, 乾 淳幸, 美舩 泰, 国分 毅

  (一社)日本肩関節学会, Sep. 2016, 日本肩関節学会抄録集, 43回, 161 - 161, Japanese


• Cuff tear arthropathyに合併した肩鎖関節部嚢腫の1例

  黒澤 尭, 国分 毅, 美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 片岡 武史

  (一社)日本肩関節学会, Sep. 2016, 日本肩関節学会抄録集, 43回, 187 - 187, Japanese


• ウサギ腱板広範囲断裂モデルに対する自家大腿筋膜補強術の検討

  片岡 武史, 国分 毅, 無藤 智之, 美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 黒澤 尭

  (一社)日本肩関節学会, Sep. 2016, 日本肩関節学会抄録集, 43回, 290 - 290, Japanese


• 老化促進モデルマウスにおける肩腱板付着部(enthesis)の検討

  美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 片岡 武史, 黒沢 尭, 黒田 良祐, 国分 毅

  (一社)日本肩関節学会, Sep. 2016, 日本肩関節学会抄録集, 43回, 292 - 292, Japanese


• 骨吸収マーカーTRACP-5bとHip Structural Analysisにおける断面係数は相関するのか? TRACP-5bの病態把握における意義について

  西本 華子, 乾 淳幸, 笠原 孝一, 酒井 良忠, 黒田 良祐, 鷲見 正敏, 楊 鴻生

  (一社)日本骨粗鬆症学会, Sep. 2016, 日本骨粗鬆症学会雑誌, 2(Suppl.1) (Suppl.1), 210 - 210, Japanese


• 老人性骨粗鬆症モデルマウスにおける肩腱板付着部(enthesis)の検討

  美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 片岡 武史, 黒澤 尭, 黒田 良祐, 国分 毅

  (一社)日本骨粗鬆症学会, Sep. 2016, 日本骨粗鬆症学会雑誌, 2(Suppl.1) (Suppl.1), 264 - 264, Japanese


• ウサギ腱板断裂修復モデルに対する自家大腿筋膜補強術の検討

  片岡 武史, 国分 毅, 無藤 智之, 美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1433 - S1433, Japanese


• 骨吸収マーカーTRACP-5bとhip structural analysisにおける断面係数の相関関係

  西本 華子, 乾 淳幸, 笠原 孝一, 酒井 良忠, 黒田 良祐, 黒坂 昌弘, 鷲見 正敏, 楊 鴻生

  (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1746 - S1746, Japanese


• 老化がアキレス腱縫合術後の腱に及ぼす影響の検討

  植田 安洋, 乾 淳幸, 美舩 泰, 国分 毅, 原田 義文, 高瀬 史明, 片岡 武史, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1791 - S1791, Japanese


• エストロゲン欠乏がラット腱細胞に及ぼす影響の検討

  乾 淳幸, 西本 華子, 美舩 泰, 高瀬 史明, 植田 安洋, 片岡 武史, 酒井 良忠, 国分 毅, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1791 - S1791, Japanese


• 超音波検査による屈筋腱断裂術後の修復過程の評価

  名倉 一成, 金谷 貴子, 原田 義文, 鷲見 正敏, 乾 淳幸, 美舩 泰, 国分 毅

  日本整形外科超音波学会, Jul. 2016, 日本整形外科超音波学会学術集会プログラム・抄録集, 28回, 68 - 68, Japanese


• 上腕二頭筋腱断裂に対してソフトアンカーにて修復を行った1例

  名倉 一成, 乾 淳幸, 美舩 泰, 国分 毅

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 483 - 483, Japanese


• 肩甲骨関節窩骨折に対する鏡視下骨接合術の治療成績

  国分 毅, 美舩 泰, 乾 淳幸, 原田 義文, 高瀬 史明, 植田 安洋, 片岡 武史, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 525 - 525, Japanese


• 老化モデルマウスにおけるアキレス腱修復後の筋腱の脂肪変性の検討

  乾 淳幸, 西本 華子, 美舩 泰, 黒坂 昌弘, 酒井 良忠

  (公社)日本リハビリテーション医学会, Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I238 - I238, Japanese


• ラット卵巣摘出モデルを使用した更年期障害における腱鞘炎発症の分子メカニズムの解明

  西本 華子, 乾 淳幸, 上羽 岳志, 国分 毅, 黒坂 昌弘, 酒井 良忠

  女性健康科学研究会, May 2016, 女性健康科学研究会受賞研究報告集, 5(1) (1), 39 - 43, Japanese


• Pain visionを使用した手根管症候群におけるしびれの評価

  乾 淳幸, 国分 毅, 美舩 泰, 坂田 亮介, 原田 義文, 高瀬 史明, 植田 安洋, 黒坂 昌弘, 西本 華子, 藤岡 宏幸

  (一社)日本手外科学会, Apr. 2016, 日本手外科学会雑誌, 32(6) (6), 1127 - 1127, Japanese


• 手根管症候群手術症例における超音波検査による母指球筋萎縮の客観的評価

  名倉 一成, 金谷 貴子, 乾 淳幸, 美舩 泰, 国分 毅

  (一社)日本手外科学会, Apr. 2016, 日本手外科学会雑誌, 33(1) (1), S119 - S119, Japanese


• 手根管症候群の電気生理学的重症度分類の治療法選択に対する役割

  金谷 貴子, 名倉 一成, 国分 毅, 美舩 泰, 乾 淳幸

  (一社)日本手外科学会, Apr. 2016, 日本手外科学会雑誌, 33(1) (1), S122 - S122, Japanese


• ラット坐骨神経圧挫モデルに対するハイドロゲルを使用した経皮的炭酸ガス投与

  乾 淳幸, 西本 華子, 植田 安洋, 美舩 泰, 国分 毅

  (一社)日本手外科学会, Apr. 2016, 日本手外科学会雑誌, 33(1) (1), S238 - S238, Japanese


• Dupuytren拘縮におけるAdvanced glycation end products(AGEs)の関与の検討

  高瀬 史明, 乾 淳幸, 植田 安洋, 片岡 武史, 国分 毅

  (一社)日本手外科学会, Apr. 2016, 日本手外科学会雑誌, 33(1) (1), S256 - S256, Japanese


• 橈骨遠位端骨折に対するAPTUS2.5の使用経験

  原田 義文, 国分 毅, 美舩 泰, 乾 淳幸, 片岡 武史, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2016, 中部日本整形外科災害外科学会雑誌, 59(春季学会) (春季学会), 227 - 227, Japanese


• 糖化最終生成物の腱板細胞に対する影響と加齢に伴う腱板組織へ影響

  美舩 泰, 国分 毅, 乾 淳幸, 原田 義文, 植田 安洋, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2016, 中部日本整形外科災害外科学会雑誌, 59(春季学会) (春季学会), 233 - 233, Japanese


• 骨吸収マーカーTRACP-5bとHip Structural Analysisにおける断面係数の相関関係

  西本 華子, 乾 淳幸, 酒井 良忠, 黒坂 昌弘, 鷲見 正敏, 楊 鴻生

  (一社)中部日本整形外科災害外科学会, Mar. 2016, 中部日本整形外科災害外科学会雑誌, 59(春季学会) (春季学会), 238 - 238, Japanese


• 骨性マレットサムの治療経験

  篠原 一生, 美舩 泰, 国分 毅, 乾 淳幸, 高瀬 史明, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2016, 中部日本整形外科災害外科学会雑誌, 59(春季学会) (春季学会), 325 - 325, Japanese


• 腱板断裂 病態に応じた治療戦略 腱板修復術における新しい補強方法の可能性

  国分 毅, 美舩 泰, 乾 淳幸, 原田 義文, 高瀬 史明, 植田 安洋, 片岡 武史, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2016, 日本整形外科学会雑誌, 90(2) (2), S351 - S351, Japanese


• 炭酸ガス経皮吸収はラット坐骨神経圧挫モデルの運動機能を回復させる

  乾 淳幸, 西本 華子, 上羽 岳志, 国分 毅, 美舩 泰, 植田 安洋, 黒坂 昌弘, 酒井 良忠

  (公社)日本整形外科学会, Mar. 2016, 日本整形外科学会雑誌, 90(3) (3), S641 - S641, Japanese


• 手根管症候群手術症例における超音波検査を用いた母指球筋萎縮の評価

  名倉 一成, 金谷 貴子, 鷲見 正敏, 坂田 亮介, 乾 淳幸, 美舩 泰, 国分 毅, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2016, 日本整形外科学会雑誌, 90(3) (3), S838 - S838, Japanese


• 化膿性肩関節炎の鏡視下術後に両下肢麻痺をきたし治療に難渋した1例

  名倉 一成, 国分 毅, 乾 淳幸, 美舩 泰, 黒坂 昌弘

  63歳男。肝硬変で、約2週間続く右肩痛と40℃の発熱、局所の発赤・腫脹を主訴とした。血液検査でCRP値と白血球数の上昇を認め、関節穿刺液で白血球増多とグラム陽性球菌を認めた。化膿性肩関節炎と診断し、関節鏡視下に病巣掻爬を行った。術中、関節内の軽度の滑膜増生と広範囲の腱板断裂を認め、関節内の滑膜組織を切除・洗浄し、Penroseドレーンを留置した。術後3日に両下肢麻痺が出現し、MRIでTh10/11レベルの胸椎化膿性脊椎炎を認めた。病巣掻爬と胸椎固定術を行い、術中組織から右肩関節と同じくグラム陽性球菌が検出された。術後、右肩と麻痺症状は徐々に改善し、右肩は初回手術のみで感染の鎮静化が得られた。しかし、背部創は治癒せずに離開し、創部からMRSAが検出された。術後1.5ヵ月に抜釘術を行い、ようやく創治癒を得た。術後2年の現在、右肩関節の可動域制限が残存するが、感染の再燃は認めていない。

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2016, JOSKAS, 41(1) (1), 58 - 59, Japanese


• 超音波検査を用いた手根管症候群の母指球筋萎縮の評価法

  名倉 一成, 金谷 貴子, 鷲見 正敏, 乾 淳幸, 美舩 泰, 国分 毅

  (株)医学書院, Jan. 2016, 臨床整形外科, 51(1) (1), 77 - 80, Japanese


• 中学野球部引退後にモザイクプラスティーを行った上腕骨小頭離断性骨軟骨炎の術後成績

  国分 毅, 美舩 泰, 乾 淳幸, 高瀬 史明, 片岡 武史, 黒坂 昌弘

  日本肘関節学会, Jan. 2016, 日本肘関節学会雑誌, 23(1) (1), S82 - S82, Japanese


• 陳旧性肘関節脱臼に対して両側側副靱帯再建を行った1例

  片岡 武史, 国分 毅, 美舩 泰, 乾 淳幸, 坂田 亮介, 原田 義文, 高瀬 史明, 植田 安洋, 黒坂 昌弘

  日本肘関節学会, Jan. 2016, 日本肘関節学会雑誌, 23(1) (1), S87 - S87, Japanese


• 中学野球部引退後にモザイクプラスティーを行った上腕骨小頭離断性骨軟骨炎の術後成績

  国分 毅, 美舩 泰, 乾 淳幸, 原田 義文, 高瀬 史明, 植田 安洋, 片岡 武史

  日本肘関節学会, 2016, 日本肘関節学会雑誌, 23(2) (2), 379 - 381, Japanese


• 中学野球部引退後にモザイクプラスティーを行った上腕骨小頭離断性骨軟骨炎の術後成績

  国分 毅, 美舩 泰, 乾 淳幸, 原田 義文, 高瀬 史明, 植田 安洋, 片岡 武史

  日本肘関節学会, 2016, 日本肘関節学会雑誌, 23(2) (2), 379 - 381, Japanese


• 超高周波プローブを用いたエコーによる橈骨神経浅枝の正常解剖

  乾淳幸, Kokubu Takeshi, Mifune Yutaka, 藤岡宏幸, Kurosaka Masahiro

  (一社)日本手外科学会, Jan. 2016, 日本手外科学会雑誌, 32(4) (4), 471 - 473, Japanese

  Meeting report


• 受傷後3ヵ月以上経過した陳旧性骨性槌指に対する石黒法による治療経験

  高瀬 史明, 国分 毅, 美舩 泰, 乾 淳幸, 坂田 亮介, 山崎 京子

  (一社)日本手外科学会, Dec. 2015, 日本手外科学会雑誌, 32(3) (3), 195 - 198, Japanese


• 成人ばね指へのステロイド腱鞘内注射の検討

  坂田 亮介, 乾 淳幸, 美舩 泰, 無藤 智之, 原田 義文, 国分 毅

  (一社)日本手外科学会, Dec. 2015, 日本手外科学会雑誌, 32(3) (3), 308 - 310, Japanese


• 手根管症候群手術例における電気生理学的重症度との関連

  金谷 貴子, 名倉 一成, 国分 毅, 美舩 泰, 乾 淳幸, 鷲見 正敏

  日本末梢神経学会, Dec. 2015, 末梢神経, 26(2) (2), 317 - 317, Japanese


• 手根管症候群手術症例における超音波検査による母指球筋萎縮の評価

  名倉 一成, 金谷 貴子, 鷲見 正敏, 乾 淳幸, 美舩 泰, 国分 毅

  日本末梢神経学会, Dec. 2015, 末梢神経, 26(2) (2), 319 - 319, Japanese


• 超音波検査による母指球筋萎縮の評価

  名倉 一成, 金谷 貴子, 乾 淳幸, 美船 泰, 国分 毅

  (一社)日本手外科学会, Nov. 2015, 日本手外科学会雑誌, 32(2) (2), 55 - 57, Japanese


• 糖負荷が腱細胞に及ぼす影響の検討

  植田 安洋, 乾 淳幸, 美舩 泰, 無藤 智之, 原田 義文, 高瀬 史明, 国分 毅, 黒坂 昌弘

  (公社)日本整形外科学会, Sep. 2015, 日本整形外科学会雑誌, 89(8) (8), S1687 - S1687, Japanese


• 神経圧挫モデルでの神経・筋肉機能回復過程における炭酸ガス経皮吸収の効果について

  西本 華子, 乾 淳幸, 上羽 岳志, 赤羽 志保, 高瀬 史明, 植田 安洋, 国分 毅, 黒坂 昌弘, 酒井 良忠

  (公社)日本整形外科学会, Sep. 2015, 日本整形外科学会雑誌, 89(8) (8), S1699 - S1699, Japanese


• 腱板大・広範囲断裂に対する大腿筋膜補強法の経時的術後経過

  国分 毅, 美舩 泰, 乾 淳幸, 坂田 亮介, 原田 義文, 高瀬 史明, 植田 安洋, 片岡 武史

  (一社)日本肩関節学会, Sep. 2015, 日本肩関節学会抄録集, 42回, 137 - 137, Japanese


• 高齢ラットにおける腱板組織への糖化最終生成物沈着の検討

  美舩 泰, 乾 淳幸, 坂田 亮介, 原田 義文, 高瀬 史明, 植田 安洋, 片岡 武史, 国分 毅

  (一社)日本肩関節学会, Sep. 2015, 日本肩関節学会抄録集, 42回, 191 - 191, Japanese


• 鏡視下烏口鎖骨靱帯再建術後感染にて抜釘を施行した1例

  名倉 一成, 金谷 貴子, 乾 淳幸, 美舩 泰, 国分 毅

  (一社)日本肩関節学会, Sep. 2015, 日本肩関節学会抄録集, 42回, 201 - 201, Japanese


• 腱板断裂に対するステロイド関節内注射の効果の検討

  坂田 亮介, 乾 淳幸, 美舩 泰, 原田 義文, 高瀬 史明, 植田 安洋, 片岡 武史, 国分 毅

  (一社)日本肩関節学会, Sep. 2015, 日本肩関節学会抄録集, 42回, 238 - 238, Japanese


• 化膿性肩関節炎の鏡視下術後に両下肢麻痺をきたし治療に難渋した1例

  名倉 一成, 乾 淳幸, 美舩 泰, 国分 毅, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4) (4), 527 - 527, Japanese


• 超音波検査による母指球筋萎縮の評価

  名倉 一成, 金谷 貴子, 美舩 泰, 乾 淳幸, 国分 毅

  (一社)日本手外科学会, Apr. 2015, 日本手外科学会雑誌, 32(1) (1), 2 - 14, Japanese


• 超高周波プローブを用いたエコーによる橈骨神経浅枝の正常解剖

  乾 淳幸, 国分 毅, 美舩 泰, 藤岡 宏幸, 黒坂 昌弘

  (一社)日本手外科学会, Apr. 2015, 日本手外科学会雑誌, 32(1) (1), 2 - 4, Japanese


• 超音波検査による母指球筋厚の評価

  名倉 一成, 金谷 貴子, 乾 淳幸, 美船 泰, 国分 毅

  (一社)日本手外科学会, Apr. 2015, 日本手外科学会雑誌, 31(6) (6), 920 - 922, Japanese


• 陳旧性骨性槌指の若年例に対する石黒法による治療経験

  高瀬史明, Mifune Yutaka, 乾淳幸, Kokubu Takeshi, 山崎京子

  (一社)日本手外科学会, Apr. 2015, 日本手外科学会雑誌, 32(1) (1), 1 - 46, Japanese

  Meeting report


• 高血糖が腱細胞に及ぼす影響についての検討

  植田安洋, 乾淳幸, Mifune Yutaka, 高瀬史明, Kokubu Takeshi

  (一社)日本手外科学会, Apr. 2015, 日本手外科学会雑誌, 32(1) (1), 1 - 15, Japanese

  Meeting report


• 画像診断 超音波検査による母指球筋評価の試み

  名倉 一成, 金谷 貴子, 乾 淳幸, 美舩 泰, 国分 毅

  著者らは超音波検査を用いた短母指外転筋(APB)および母指対立筋(OPP)の評価方法を考案し、健常ボランティア68例を対象に検討した。その結果、今回対象とした20〜30歳代の健常人では、OPP、APBの測定値において標準偏差のばらつきの少ない測定結果が得られた。OPP、APBは男女とも20〜30歳代間での差がなく、右側で大きい傾向を示したが、左側との有意差はなかった。男女間での比較では、男性の20歳代APB(右、左)および30歳代APB(右)において同年代の女性よりも有意に高値であったことから、測定値を個体間で比較する際には男女を分けて検討する必要があると思われた。

  (株)南江堂, Mar. 2015, 整形外科, 66(3) (3), 241 - 243, Japanese


• 関節鏡視下に開窓掻爬骨移植を施行した上腕骨近位部骨嚢腫の1例

  名倉 一成, 国分 毅, 乾 淳幸, 美舩 泰, 黒坂 昌弘

  24歳女。明らかな誘因のない右肩関節痛を主訴とした。初診時の右肩単純X線・CT像では上腕骨近位に周囲との境界明瞭な骨透亮像を認め、MRIにて上腕骨近位にT1強調像で低信号・T2強調像で高信号を呈する腫瘤性病変と、三角筋下に一部高信号部分を認めた。上腕骨近位部骨嚢腫による病的骨折の診断で、全身麻酔下関節鏡視下手術を行い、透視を併用しながら骨皮質の菲薄部位を開窓し、腫瘍内壁を掻爬して人工骨を充填した。術後2ヵ月で可動域は左右差なく回復し、職場復帰した。術後半年経過現在、痛みや可動域制限なく再発を認めていない。

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2015, JOSKAS, 40(1) (1), 74 - 75, Japanese


• 超音波検査による母指球筋評価の試み

  名倉 一成, 金谷 貴子, 鷲見 正敏, 乾 淳幸, 美舩 泰, 国分 毅, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2015, 日本整形外科学会雑誌, 89(2) (2), S256 - S256, Japanese


• 超高周波プローブを用いたエコーによる前腕表在神経の観察

  山崎 善功, 乾 淳幸, 国分 毅, 美舩 泰, 高瀬 史明, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2015, 中部日本整形外科災害外科学会雑誌, 58(春季学会) (春季学会), 85 - 85, Japanese


• 超音波検査による手根管症候群の母指球筋萎縮の評価

  名倉 一成, 金谷 貴子, 美舩 泰, 乾 淳幸, 国分 毅, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2015, 中部日本整形外科災害外科学会雑誌, 58(春季学会) (春季学会), 85 - 85, Japanese


• 中高年スポーツ競技者の肩腱板大・広範囲断裂に対する鏡視下腱板修復術の検討

  国分 毅, 美舩 泰, 乾 淳幸, 坂田 亮介, 植田 安洋, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2015, 中部日本整形外科災害外科学会雑誌, 58(春季学会) (春季学会), 172 - 172, Japanese


• 肘部管症候群に対するPain Visionを用いた疼痛の定量的評価

  乾 淳幸, 国分 毅, 美舩 泰, 無藤 智之, 原田 義文, 高瀬 史明, 西本 華子, 植田 安洋, 黒坂 昌弘

  日本肘関節学会, Jan. 2015, 日本肘関節学会雑誌, 22(1) (1), S128 - S128, Japanese


• 超音波検査による母指球筋の客観的評価の検討

  名倉 一成, 金谷 貴子, 鷲見 正敏, 乾 淳幸, 美舩 泰, 国分 毅

  日本末梢神経学会, Dec. 2014, 末梢神経, 25(2) (2), 335 - 335, Japanese


• ステロイドとPlatelet rich plasma(PRP)の正常腱組織に対する影響

  無藤 智之, 美舩 泰, 乾 淳幸, 原田 義文, 高瀬 史明, 国分 毅, 名倉 一成

  ステロイドとPlatelet rich plasma(PRP)の正常腱組織に対する影響について検討した。雄性SDラットを用い、生理食塩水注射群(C群)、トリアムシノロンアセトニド(T)注射群(T群)、T+PRP注射群(TP群)、PRP注射群(P群)に分けた。アキレス腱はC群のコラーゲン繊維の走行は正常腱組織様であったが、T群では組織表層への細胞浸潤、空胞形成を認めたが、TP群とP群では変化は認めなかった。最大破断強度はT群では有意に低下したが、TP群では有意な低下は認めなかった。弾性率はT群では有意に低下したが、TP群では有意な低下を認めなかった。T群とTP群の間に有意差を認めた。

  (一社)日本肩関節学会, Nov. 2014, 肩関節, 38(3) (3), 1028 - 1030, Japanese


• Platelet rich plasmaによる腱板由来細胞の脂肪分化抑制

  美舩 泰, 乾 淳幸, 無藤 智之, 原田 義文, 高瀬 史明, 国分 毅, 名倉 一成

  腱板断裂の断端部に脂肪変性が起こっているか否か検討するとともに、Platelet rich plasma(PRP)が腱板由来細胞の脂肪分化を抑制するか検討した。方法は、鏡視下腱板修復術施行例6例の術前に腱板断裂組織を採取して凍結切片を作成し、オイルレッドO染色を行うことで脂肪変性の有無を調べた。さらに、採取した腱板組織の一部から腱板由来細胞を分離し、これをPRP存在下に脂肪分化培地で培養し、脂肪分化能およびcell viabilityの評価を行った。結果、オイルレッドO染色陽性の脂肪変性が6例中3例(50%)で認められた。PRPは腱板由来細胞の脂肪変性を抑制し、また、脂肪変性が誘導されている状態であってもPRPは腱板由来細胞のviabilityを高めることが示唆された。

  (一社)日本肩関節学会, Oct. 2014, 肩関節, 38(2) (2), 556 - 559, Japanese


• 低出力超音波パルスによるヒト腱板断裂組織由来細胞の腱分化能への影響

  名倉 一成, 国分 毅, 乾 淳幸, 美舩 泰, 原田 義文, 無藤 智之, 高瀬 史明

  著者等は、腱板修復術の成績を向上させるためには腱付着部の再生が重要と考え、ヒト腱板断裂組織由来細胞の多分化能について研究を行ってきた。今回、低出力超音波パルス(LIPUS)照射によって腱骨移行部の修復を促進すれば早期に力学的な強度が回復するのではないかと考え、ヒト腱板断裂組織由来細胞の腱分化能への影響について検討した。方法は、鏡視下腱板修復術施行例4例から分離したヒト腱板断裂組織由来細胞を平面培養し、LIPUS照射群とコントロール群に分け、腱分化の指標として[Type I collagen(collagen I)][Type III collage(collagen III)][Scleraxis(SCX)]の発現をreal-time PCR法で解析した。結果、培養5日目にはコントロール群に比べてLIPUS照射群で3指標とも有意な発現増強を認めたが、培養10日目にはcollage Iとcollage IIIの発現に有意な群間差なく、SCXの発現はLIPUS群が有意に低かった。

  (一社)日本肩関節学会, Oct. 2014, 肩関節, 38(2) (2), 591 - 594, Japanese


• 鏡視下腱板修復術後の腱板再断裂が筋力に及ぼす影響

  国分 毅, 美舩 泰, 乾 淳幸, 無藤 智之, 原田 義文, 高瀬 史明, 名倉 一成

  腱板完全断裂に対して鏡視下修復術を行い術後1年以上観察しえた52例を対象とし、術後1年時のMRI所見から再断裂群(14例)と非再断裂群(38例)に分け、術前と術後6ヵ月・1年時の「外転筋力健患比」「棘上筋萎縮率」を群間比較した。結果、術前には両指標とも有意な群間差は認めなかった。術後6ヵ月時の「外転筋力健患比」は非再断裂群のみ術前に比べて有意に改善し、両群間に有意差を認めた。術後6ヵ月時の「棘上筋萎縮率」は、非再断裂群で術前に比べて僅かに低下したのに対して再断裂群は上昇し、有意な群間差を認めた。術後1年時の「外転筋力健患比」は両群とも術後6ヵ月時に比べて有意に改善したが、群間差は術後6ヵ月時よりも拡大した。術後1年時の「棘上筋萎縮率」は、非再断裂群で術後6ヵ月時に比べて有意に低下し、再断裂群は術後6ヵ月時と大差なく、群間差は拡大した。

  (一社)日本肩関節学会, Oct. 2014, 肩関節, 38(2) (2), 599 - 602, Japanese


• 問題症例の筋電図・伝導検査 高位正中神経麻痺の2症例

  Sekiguchi Kenji, 野田 佳克, 藤堂 紘之, 乾 淳幸, 美舩 泰, 国分 毅, Kanda Fumio, Toda Tatsushi

  (一社)日本臨床神経生理学会, Oct. 2014, 臨床神経生理学, 42(5) (5), 267 - 267, Japanese

  Meeting report


• 大腿筋膜graft augmentation法を用いた鏡視下腱板修復術

  国分 毅, 美舩 泰, 乾 淳幸, 無藤 智之, 原田 義文, 高瀬 史明, 植田 安洋

  (一社)日本肩関節学会, Sep. 2014, 日本肩関節学会抄録集, 41回, 147 - 147, Japanese


• マウス筋芽細胞の脂肪分化及び筋分化に対するPRP投与効果の検討

  高瀬 史明, 乾 淳幸, 美舩 泰, 無藤 智之, 原田 義文, 植田 安洋, 国分 毅

  (一社)日本肩関節学会, Sep. 2014, 日本肩関節学会抄録集, 41回, 169 - 169, Japanese


• 糖化最終生成物が腱板細胞に与える影響

  美舩 泰, 乾 淳幸, 無藤 智之, 原田 義文, 高瀬 史明, 植田 安洋, 国分 毅

  (一社)日本肩関節学会, Sep. 2014, 日本肩関節学会抄録集, 41回, 170 - 170, Japanese


• 石灰化病変により手根管症候群をきたした1例

  Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Sep. 2014, 中部日本整形外科災害外科学会雑誌, 57(5) (5), 1203 - 1204, Japanese

  Meeting report


• Bone morphoenetic protein(BMP)-3bによるヒト肩腱板由来細胞の脂肪分化制御

  Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2014, 日本整形外科学会雑誌, 88(8) (8), S1436 - S1436, Japanese

  Meeting report


• ラット腱板断裂に対するヒト腱板由来細胞シートを用いた腱板修復術

  Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2014, 日本整形外科学会雑誌, 88(8) (8), S1439 - S1439, Japanese

  Meeting report


• 関節鏡視下に開窓掻爬骨移植を施行した上腕骨近位部骨嚢腫の1例

  名倉 一成, 金谷 貴子, 鷲見 正敏, 乾 淳幸, 美舩 泰, 国分 毅, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2014, JOSKAS, 39(4) (4), 226 - 226, Japanese


• 拘縮を伴う腱板断裂に対するマニピュレーションと鏡視下関節包切離術を併用した鏡視下腱板修復術の検討

  Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2014, JOSKAS, 39(4) (4), 339 - 339, Japanese

  Meeting report


• 化膿性肩関節炎に対するペンローズドレーン留置と鏡視下病巣掻爬の有効性

  国分 毅, 美舩 泰, 乾 淳幸, 無藤 智之, 原田 義文, 高瀬 史明, 黒坂 昌弘

  (一社)日本骨・関節感染症学会, Jun. 2014, 日本骨・関節感染症学会プログラム・抄録集, 37回, 79 - 79, Japanese


• 示指MP関節側副靱帯修復後の超音波検査が有用であった1例

  名倉 一成, 金谷 貴子, 鷲見 正敏, 乾 淳幸, 美舩 泰, 国分 毅

  17歳女。バレーボールの際に左示指にボールが当たって受傷した。保存的加療で改善せず、左示指MP関節の痛みと不安定感が残存した。単純X線像では、基節骨近位橈側に剥離骨片を認めた。MRIでは、T1およびT2強調像において示指MP関節橈側に高信号を示す骨片を認め、それに連続する低信号を示す膨隆した側副靱帯を認めた。超音波検査所見では基節骨より剥離した骨片と緊張の低下した側副靱帯を認めた。左示指MP関節部橈側側副靱帯損傷と診断し、手術加療を施行した。術後3週間のギプス固定を行い、その後可動域訓練を開始した。術後経過は良好で、術後1年経過時には可動域制限やMP関節部の痛みや不安定感は消失していた。

  (一社)中部日本整形外科災害外科学会, May 2014, 中部日本整形外科災害外科学会雑誌, 57(3) (3), 647 - 648, Japanese


• トリアムシノロンアセトニドによる腱脆弱化は適正な使用量、投与間隔で回避できる

  原田 義文, 美舩 泰, 乾 淳幸, 西本 華子, 酒井 良忠, 黒坂 昌弘

  (公社)日本リハビリテーション医学会, May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S309 - S309, Japanese


• 超音波検査を用いたばね指に対する腱鞘内トリアムシノロン注射の治療効果に関する検討

  美舩 泰, 乾 淳幸, 原田 義文, 酒井 良忠, 黒坂 昌弘

  (公社)日本リハビリテーション医学会, May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S310 - S310, Japanese


• 手根管症候群のしびれの評価におけるPain Visionの有用性の検討

  乾 淳幸, 美舩 泰, 西本 華子, 原田 義文, 酒井 良忠, 黒坂 昌弘

  (公社)日本リハビリテーション医学会, May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S373 - S373, Japanese


• マウス筋芽細胞の脂肪分化および筋分化に対するplatelet-rich-plasma投与効果の検討

  高瀬 史明, 乾 淳幸, 美舩 泰, 無藤 智之, 国分 毅

  (一社)日本手外科学会, Apr. 2014, 日本手外科学会雑誌, 31(1) (1), 1 - 7, Japanese


• ヒト腱由来細胞シートを用いたラット腱付着部修復

  原田 義文, 美舩 泰, 国分 毅, 乾 淳幸, 無藤 智之

  (一社)日本手外科学会, Apr. 2014, 日本手外科学会雑誌, 31(1) (1), 1 - 9, Japanese


• ステロイド注射の腱に対する弊害はplatelet rich plasmaにより予防できるか?

  無藤 智之, 美舩 泰, 乾 淳幸, 原田 義文, 国分 毅

  (一社)日本手外科学会, Apr. 2014, 日本手外科学会雑誌, 31(1) (1), 1 - 16, Japanese


• 超音波検査による母指球筋の評価

  名倉 一成, 金谷 貴子, 国分 毅, 美舩 泰, 乾 淳幸

  (一社)日本手外科学会, Apr. 2014, 日本手外科学会雑誌, 31(1) (1), 1 - 42, Japanese


• ばね指に対する腱鞘内トリアムシノロン注射の治療効果に関する検討

  美舩 泰, 乾 淳幸, 原田 義文, 高瀬 史明, 国分 毅

  (一社)日本手外科学会, Apr. 2014, 日本手外科学会雑誌, 31(1) (1), 2 - 17, Japanese


• 手根管症候群のしびれに対するPain Visionを用いた評価の検討

  Kurosaka Masahiro

  (一社)日本手外科学会, Apr. 2014, 日本手外科学会雑誌, 31(1) (1), 1 - 2, Japanese

  Meeting report


• 手根管症候群診断時におけるPain visionの有用性についての検討

  乾 淳幸, 国分 毅, 美舩 泰, 西本 華子, 無藤 智之, 原田 義文, 高瀬 史明, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(2) (2), S101 - S101, Japanese


• 鏡視下腱板修復術において術前疼痛が術後疼痛に与える影響に関する検討

  美舩 泰, 国分 毅, 乾 淳幸, 無藤 智之, 原田 義文, 高瀬 史明, 名倉 一成, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(2) (2), S218 - S218, Japanese


• 特発性手根管症候群の正中神経の断面積と神経伝導速度についての検討 術後1年のフォローアップを施行して

  西本 華子, 国分 毅, 乾 淳幸, 美舩 泰, 原田 義文, 名倉 一成, 酒井 良忠, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(2) (2), S227 - S227, Japanese


• 腱板断裂に対する治療の将来展望 鏡視下腱板修復術 suture bridge法と大腿筋膜graft augmentation法

  国分 毅, 美舩 泰, 乾 淳幸, 無藤 智之, 原田 義文, 高瀬 史明, 名倉 一成, 谷口 充, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(2) (2), S379 - S379, Japanese


• 屈筋腱断裂術後の修復過程におけるエコーの有効性

  名倉 一成, 金谷 貴子, 鷲見 正敏, 乾 淳幸, 美舩 泰, 国分 毅, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(3) (3), S794 - S794, Japanese


• 腱板大・広範囲断裂に対する大腿筋膜graft augmentation法を用いた鏡視下腱板修復術の検討

  国分 毅, 美舩 泰, 乾 淳幸, 原田 義文, 高瀬 史明, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2014, 中部日本整形外科災害外科学会雑誌, 57(春季学会) (春季学会), 102 - 102, Japanese


• 肩関節脱臼骨折に腱板断裂および腋窩神経麻痺を合併した一例

  高瀬 史明, 国分 毅, 美舩 泰, 乾 淳幸, 無藤 智之, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2014, 中部日本整形外科災害外科学会雑誌, 57(春季学会) (春季学会), 181 - 181, Japanese


• 巨大骨嚢胞を伴う肘関節症に対して人工肘関節置換術を行った1例

  林 範人, 国分 毅, 美舩 泰, 乾 淳幸, 秋末 敏宏, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2014, 中部日本整形外科災害外科学会雑誌, 57(春季学会) (春季学会), 184 - 184, Japanese


• 関節鏡視下手術が有用であった肘滑膜性骨軟骨腫症の1例

  名倉 一成, 国分 毅, 乾 淳幸, 美舩 泰, 黒坂 昌弘

  症例は30歳女性で、2年前より右肘関節の伸展制限が持続し、近医にてX線撮影を受けるも異常は指摘されず、その後も症状は改善しないため、当科を受診した。初診時、単純X線では異常所見はなかったが、MRIにて肘関節内に滑膜組織の増生、T1強調像で等信号、T2強調像で不均一な高信号を呈する腫瘤性病変を認めた。以上より、肘滑膜性骨軟骨腫症と診断し、関節鏡視下に遊離体摘出と滑膜切除を行った。術後は肘関節の可動域訓練を中心とした理学療法を施行し、肘伸展制限は術前の-25°から術後は-5°、屈曲は術前130°から術後140°に改善した。術後1年経過した現在、再発は認めず、良好に経過している。

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2014, JOSKAS, 39(1) (1), 4 - 5, Japanese


• サルコペニアが高齢者の慢性疼痛発症に及ぼす因子についての検討

  乾 淳幸, 酒井 良忠, 西本 華子

  三井住友海上福祉財団, 2014, 研究結果報告書集 : 交通安全等・高齢者福祉, 20, 53 - 55, Japanese


• 肘滑膜性軟骨腫症に対して関節鏡視下手術が有用であった1例

  名倉 一成, 美舩 泰, 乾 淳幸, 原田 義文, 無藤 智之, 国分 毅

  30歳女。明らかな外傷歴がなく、約2年前から右肘関節の伸展制限を自覚した。症状が改善しないため受診した。初診時の現症では右肘関節の明らかな腫脹、熱感および圧痛は認めなかった。伸展制限を認めたが、運動時痛や右上肢の知覚障害は認めなかった。右肘単純X線写真では明らかな異常を認めず、MRIにて肘関節内に滑膜組織の増生、T1強調像で等信号、T2強調像で不均一な高信号を呈する腫瘤性病変を認めた。滑膜性骨軟骨腫症を疑い、肘関節内の腫瘤性病変に対して全身麻酔下に関節鏡視下手術を行った。術中は関節内に充満した多数の白色遊離体と増生した滑膜を認めた。前方および後方の関節内から十分に遊離体を摘出し、増生した滑膜組織を切除した。術後は、肘関節の可動域訓練を中心とした理学療法を施行し、術前の肘伸展制限は-25→-5°、屈曲は130→140°まで改善した。現在、術後1年経過し、疼痛なく職場復帰している。

  日本肘関節学会, Dec. 2013, 日本肘関節学会雑誌, 20(2) (2), 135 - 137, Japanese


• 上肢術後固定に対して閉所恐怖症状を呈した患者に対する工夫

  名倉 一成, 金谷 貴子, 乾 淳幸, 美船 泰, 国分 毅

  2009〜2012年に上肢術後外固定を行った患者のなかに、固定直後から閉塞感と不安感を強く訴え、固定の除去を希望した者が8名いた。内訳は男性5名、女性3名、年齢35〜56歳であった。閉所恐怖症状の自覚があったのは6名、自覚がなかったのは2名であり、自覚があった6名のうち外固定と閉所恐怖症状との関連性を認識していたのは2名であった。対応策として、患者に対し外固定と閉所恐怖症状との関連性を説明した後、固定用包帯を薄くしたり、ギプスに割入れを行って隙間から皮膚を見せるようにしたところ、症状は全例改善し、治療を続行することができた。代表例として、閉所恐怖症状の自覚があり、固定との関連性を認識していた1例と、閉所恐怖症状の自覚がなかった1例を提示した。

  (一社)日本手外科学会, Nov. 2013, 日本手外科学会雑誌, 30(2) (2), 170 - 172, Japanese


• 示指MP関節側副靱帯修復後の超音波検査が有用であった1例

  名倉 一成, 金谷 貴子, 鷲見 正敏, 乾 淳幸, 美舩 泰, 国分 毅

  (一社)中部日本整形外科災害外科学会, Sep. 2013, 中部日本整形外科災害外科学会雑誌, 56(秋季学会) (秋季学会), 241 - 241, Japanese


• ヒト腱板由来細胞シートを用いたラット腱板断裂修復術

  原田 義文, 美舩 泰, 国分 毅, 乾 淳幸, 無藤 智之, 高瀬 史明, 名倉 一成, 黒坂 昌弘

  (一社)日本肩関節学会, Sep. 2013, 肩関節, 38(1) (1), 178 - 178, Japanese


• Platelet rich plasmaによる腱板由来細胞の脂肪分化抑制

  美舩 泰, 国分 毅, 乾 淳幸, 無藤 智之, 原田 義文, 高瀬 史明, 名倉 一成, 黒坂 昌弘

  (一社)日本肩関節学会, Sep. 2013, 肩関節, 38(1) (1), 179 - 179, Japanese


• ステロイドとplatelet rich plasmaの腱に対する影響

  無藤 智之, 国分 毅, 美舩 泰, 乾 淳幸, 原田 義文, 高瀬 史明, 名倉 一成, 黒坂 昌弘

  (一社)日本肩関節学会, Sep. 2013, 肩関節, 38(1) (1), 180 - 180, Japanese


• 低出力超音波パルスによるヒト腱板組織由来細胞の腱分化への影響

  名倉 一成, 国分 毅, 美舩 泰, 乾 淳幸, 原田 義文, 無藤 智之, 高瀬 史明

  (一社)日本肩関節学会, Sep. 2013, 肩関節, 38(1) (1), 210 - 210, Japanese


• 鏡視下腱板修復術後の腱板再断裂が筋力に及ぼす影響

  国分 毅, 美舩 泰, 乾 淳幸, 無藤 智之, 原田 義文, 高瀬 史明, 名倉 一成

  (一社)日本肩関節学会, Sep. 2013, 肩関節, 38(1) (1), 241 - 241, Japanese


• HedgehogおよびWntシグナルによる、関節表層軟骨におけるsuperficial zone protein分泌制御

  岩倉 崇, 乾 淳幸, Reddi Hari A.

  (公社)日本整形外科学会, Aug. 2013, 日本整形外科学会雑誌, 87(8) (8), S1332 - S1332, Japanese


• 関節鏡視下手術が有用であった肘滑膜性軟骨腫症の1例

  名倉 一成, 金谷 貴子, 鷲見 正敏, 国分 毅, 乾 淳幸, 美舩 泰, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4) (4), 228 - 228, Japanese


• 皮質骨付き腸骨移植を併用した舟状骨骨折偽関節に対する骨接合術の治療成績

  乾 淳幸, 美舩 泰, 西本 華子, 国分 毅, 牧野 健

  (一社)日本手外科学会, Apr. 2013, 日本手外科学会雑誌, 30(1) (1), 2 - 16, Japanese


• 上肢術後固定に対して閉所恐怖症状を呈した患者に対する工夫

  名倉 一成, 金谷 貴子, 乾 淳幸, 美舩 泰, 国分 毅

  (一社)日本手外科学会, Apr. 2013, 日本手外科学会雑誌, 30(1) (1), 2 - 30, Japanese


• 橈骨遠位端骨折に対する掌側ロッキングプレートを用いた骨接合術の検討

  Kokubu Takeshi, Mifune Yutaka, 乾 淳幸, 名倉 一成, 黒田 司

  (一社)日本手外科学会, Apr. 2013, 日本手外科学会雑誌, 30(1) (1), 1 - 55, Japanese

  Meeting report


• ステント状ポリ-L-乳酸scaffoldを用いた家兎モデルでの靱帯再生の検討

  西本 華子, Kokubu Takeshi, Mifune Yutaka, 乾 淳幸, 無藤 智之

  (一社)日本手外科学会, Apr. 2013, 日本手外科学会雑誌, 30(1) (1), 2 - 31, Japanese

  Meeting report


• 肩関節症に対する人工肩関節置換術の治療経験

  茨木 一行, 国分 毅, 美舩 泰, 乾 淳幸, 西本 華子, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2013, 中部日本整形外科災害外科学会雑誌, 56(春季学会) (春季学会), 114 - 114, Japanese


• 糖化ストレス抑制による高齢者における変性肩腱板断裂予防の可能性

  美舩 泰, 国分 毅, 乾 淳幸

  三井住友海上福祉財団, 2013, 研究結果報告書集 : 交通安全等・高齢者福祉, 19, 125 - 128, Japanese


• 生体吸収性ステント状PLLA scaffoldを用いたウサギ内側々副靱帯再生

  西本 華子, 国分 毅, 美舩 泰, 乾 淳幸, 無藤 智之, 原田 義文, 藤岡 宏幸

  日本肘関節学会, Jan. 2013, 日本肘関節学会雑誌, 20(1) (1), S39 - S39, Japanese


• 上腕骨滑車部離断性骨軟骨炎の1例

  原田 義文, 国分 毅, 美舩 泰, 乾 淳幸, 西本 華子, 無藤 智之, 名倉 一成

  日本肘関節学会, Jan. 2013, 日本肘関節学会雑誌, 20(1) (1), S128 - S128, Japanese


• ポリ乳酸・グリコール酸(PLG)スカフォールドを使用した家兎肩腱板再生の試み

  乾 淳幸, 国分 毅, 坂田 亮介, 美舩 泰, 無藤 智之, 藤岡 宏幸

  スカフォールド作成について、スカフォールドが家兎の肩腱板欠損モデルのおいても有効であるという仮説に基づき、エレクトロスピニング法で作成したPLGスカフォールドを家兎肩腱板欠損に移植し、線維軟骨を介した組織再生を得ることができた。肉眼的には欠損部は白色を帯びた組織で再生されており、感染や強い炎症の兆候は認められなかった。組織学評価では、術後4週のHE染色でスカフォールド内に細胞が侵入してきているが、腱骨移行部ではスカフォールド線維が残存し、骨や腱骨移行部の線維軟骨の再生は確認されなかった。術後8週時点でスカフォールドはほぼ吸収され、腱骨移行部には細胞密度の高い組織が腱の長軸方向に配列している像が確認できた。術後16週時点では腱骨移行部に線維軟骨様の組織が認められたが、腱骨移行部でのタイドマークは確認されなかった。術後16週に行った免疫染色では骨部分と、再生腱全体に1型コラーゲンの発現が認められた。2型コラーゲンによる免疫染色では腱骨移行部の線維軟骨様の組織に強い発現が認められた。3型コラーゲンによる免疫染色では腱骨移行部には発現を認めず、再生腱部分に弱い発現が認められた。このスカフォールドは腱板再生の人工材料と成り得る可能性が示唆された。

  (一社)日本肩関節学会, Sep. 2012, 肩関節, 36(3) (3), 913 - 916, Japanese


• 【肩の腱板-基礎から学ぶ臨床-】人工吸収性材料による肩腱板の再生 家兎棘下筋腱による検討

  国分 毅, 乾 淳幸, 美舩 泰, 黒坂 昌弘

  (株)メジカルビュー社, Jul. 2012, 関節外科, 31(7) (7), 742 - 748, Japanese


• ヒト腱板組織由来細胞の軟骨分化の可能性

  名倉 一成, 国分 毅, 西本 華子, 坂田 亮介, 乾 淳幸, 牧野 健

  腱付着部は組織学的にdirect insertionと呼ばれる4層構造を呈しており、腱実質が非石灰化線維軟骨、石灰化線維軟骨を介して骨へと連続的に移行している。そこに介在する軟骨は、腱付着部での力学的ストレスを軽減するなどの大切な役割を果たしており、ヒト腱板断裂修復術後の良好な成績には腱付着部の再生が重要と考えられる。そこで今回、腱板断裂患者から採取した断裂組織を用いて、同組織由来細胞における軟骨分化の可能性について検討した。その結果、ヒト腱板断裂組織由来細胞には骨髄間葉系幹細胞と同様な幹細胞が存在し、至適な環境にあれば軟骨に分化して腱付着部の再生に関与する可能性が示唆された。

  (一社)日本肩関節学会, Nov. 2011, 肩関節, 35(3) (3), 829 - 832, Japanese


• ポリ乳酸グリコール酸シートを使用した家兎肩腱板再生の試み

  乾 淳幸, 国分 毅, 美舩 泰, 坂田 亮介, 西本 華子, 無藤 智之, 名倉 一成, 藤岡 宏幸, 黒坂 昌弘

  (一社)日本肩関節学会, Sep. 2011, 肩関節, 36(1) (1), 66 - 66, Japanese


• ポリ乳酸グリコール酸(PLG)スキャフォールドを用いたウサギ肩腱板再生

  国分 毅, 美舩 泰, 乾 淳幸, 名倉 一成, 坂田 亮介, 西本 華子, 無藤 智之, 藤岡 宏幸, 佐竹 真, 福平 由佳子, 兼子 博章, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1093 - S1093, Japanese


• 成人上腕骨遠位部骨折に対する治療成績

  牧野 健, 国分 毅, 名倉 一成, 乾 淳幸, 坂田 亮介, 西本 華子, 池田 里砂, 黒坂 昌弘, 藤岡 宏幸

  (公社)日本整形外科学会, Feb. 2011, 日本整形外科学会雑誌, 85(2) (2), S142 - S142, Japanese


• ヒト断裂腱板組織由来細胞の多分化能についての検討

  名倉 一成, 国分 毅, 牧野 健, 西本 華子, 坂田 亮介, 乾 淳幸, 池田 里砂, 黒坂 昌弘

  (公社)日本整形外科学会, Feb. 2011, 日本整形外科学会雑誌, 85(2) (2), S158 - S158, Japanese


• 成人上腕骨顆部骨折に対するLCP distal humerus plateの使用経験

  乾 淳幸, 牧野 健, 名倉 一成, 黒坂 昌弘

  (一社)日本骨折治療学会, Feb. 2011, 骨折, 33(1) (1), 61 - 63, Japanese


• 生体吸収性ナノファイバーscaffoldを用いた骨軟骨修復

  坂田 亮介, 国分 毅, 名倉 一成, 西本 華子, 牧野 健, 豊川 成和, 乾 淳幸, 兼子 博章, 藤岡 宏幸, 黒坂 昌弘

  日本肘関節学会, Jan. 2011, 日本肘関節学会雑誌, 18(1) (1), S61 - S61, Japanese


• 上腕骨通顆骨折に対するLCP Distal Humerus Plateの使用経験

  乾 淳幸, 牧野 健, 国分 毅, 名倉 一成, 豊川 成和

  外側にLCP Distal Humerus Plate(DHP)を用いて骨接合術を行った、上腕骨通顆骨折8例(男性1例、女性7例、73.9歳)について検討した。全例、平均4ヵ月で骨癒合が得られた。また、術後平均2.2週で可動域訓練を行ったところ、肘関節可動域は伸展:平均-26.4度、屈曲:平均125度となり、JOAスコアは平均78.3点であった。術後神経麻痺を生じた症例、偽関節に至った症例はなかったが、サポート付きプレートを使用しない症例では骨癒合の遷延化もみられ、十分な固定性が得られないと判断した症例に対しては内側にもプレートを使用したdouble plate固定を考慮すべきだと考えられた。

  日本肘関節学会, Dec. 2010, 日本肘関節学会雑誌, 17(2) (2), 143 - 145, Japanese


• 舟状骨偽関節に伴う変形性手関節症に対する部分手関節固定術の治療成績

  乾 淳幸, 藤岡 宏幸, 坂田 亮介, 豊川 成和, 名倉 一成, 国分 毅, 牧野 健, 黒坂 昌弘

  舟状骨骨折偽関節に続発する関節症(SNAC wrist)に対し、部分手関節固定術(有頭・有鉤・月状・三角骨関節固定術)を施行したので、その臨床成績を検討した。対象は1995〜2008年に加療した6症例(全例男性、平均年齢50歳)で、受傷から手術までの期間は平均18年、Watson等の分類でstage 2が1例、stage 3が5例であった。1)骨癒合は全例で得られ、疼痛は全例で改善した。2)4例で疼痛が消失し、5例は現職に復帰可能であった。3)握力は手術前後で変化は認められなかった。4)手関節の可動域は術前と比較して術後は有意な低下が認められた。5)Cooneyの機能評価では平均69.2点であり、good 4例、fair 1例、poor 1例であった。6)項目別に検討すると、疼痛や職業復帰といった項目では高い点数が得られていたが、可動域や握力の点数は低かった。

  (一社)日本骨折治療学会, Dec. 2010, 骨折, 32(4) (4), 679 - 681, Japanese


• 腱組織再生に適した生体吸収性高分子scaffoldの形状の検討

  乾 淳幸, 国分 毅, 牧野 健, 名倉 一成, 坂田 亮介, 黒坂 昌弘

  腱組織再生に適した生体吸収性高分子scaffoldの形状を検討するため、ポリ-L-乳酸線維(PLLA)により表面平滑・裏面羽毛状のSheetDと、両面平滑のSheetPを作製し、家兎の背筋筋膜上に移植して移植後3週・6週に評価を行った。組織学的に、SheetDではPLLA間隙に良好な細胞侵入を認め、特に起毛側では膠原線維がsheet外側まで広がっていた。SheetPではPLLA間隙に組織はほとんど侵入せず、膠原線維はsheet周囲を取り巻くように存在していた。摘出sheetの長軸方向引っ張り試験では、初期強度を100%とした場合、SheetDの平均最大破断強度は移植後3週131.1%、6週96.9%、SheetPはそれぞれ87.5%、57.4%であった。破断に要したエネルギーは、SheetDで3週後106%、6週後75.9%、SheetPはそれぞれ74.3%、37.7%であった。移植後6週での引き剥がし試験では、SheetDの起毛側で平均31.3N、平滑側で23.1N、SheetPでは23.6Nの力を要した。以上、表面平滑・裏面羽毛状のPLLA製sheetは組織再生に有用であると考えられた。

  (一社)日本手外科学会, Nov. 2010, 日本手外科学会雑誌, 27(2) (2), 17 - 19, Japanese


• 【肩関節・肩甲帯部疾患 病態・診断・治療の現状】治療 保存的治療と手術的治療の現状 その他 化膿性肩関節炎 化膿性肩関節炎に対する鏡視下デブリドマンと開放性ドレナージ

  国分 毅, 名倉 一成, 乾 淳幸, 坂田 亮介, 西本 華子, 牧野 健, 黒坂 昌弘

  2005〜2009年の間に化膿性肩関節炎に対して治療を行った8例の成績を報告した。治療内容は、全身麻酔下で鏡視下デブリドマンを施行しドレーン留置したものが3例、局所麻酔下でドレーン留置した後、二期的に鏡視下デブリドマンとドレーン再留置を行ったものが3例、事前に局所麻酔下でドレーン留置し鏡視下デブリドマンを予定したが、感染徴候が軽快したため前処置のみで十分であったものが2例であった。最終処置からCRP陰性化までの期間は、術後化膿性脊椎炎を合併した1例を除くと平均28.1日(5〜53日)で、感染の再燃を認めた症例はなかった。最終観察時のJOAスコアは、統合失調症で意思疎通困難な1例を除くと平均85.3点(76〜100点)であった。代表例1例を提示した。

  (株)南江堂, Oct. 2010, 別冊整形外科, (58) (58), 206 - 209, Japanese


• Enthesisの基礎 構造と機能 EnthesisにおけるX型コラーゲンの発現とその意義

  藤岡 宏幸, 国分 毅, 名倉 一成, 豊川 成和, 乾 淳幸, 坂田 亮介, 黒坂 昌弘

  ラットアキレス腱付着部の成長過程や腱断裂後の修復過程を組織学的に解析し、enthesisにおけるX型コラーゲン発現の意義を考察した。各過程で摘出したアキレス腱に対し、H-E染色による組織学的解析と抗X型コラーゲン抗体を用いた免疫組織学的解析を行った結果、X型コラーゲンは線維軟骨の石灰化に先立って発現しており、X型コラーゲンが細胞外基質に一過性に発現する状態は進行する石灰化を、細胞内に持続的に発現する状態は石灰化の停止を示唆している可能性があると考えられた。また、腱付着部を再縫着した場合には術後早期に多数の軟骨細胞が出現し、細胞外基質にX型コラーゲンの発現が認められた。X型コラーゲンは腱付着部における石灰化の制御に重要な役割を果たしており、切離された腱付着部を修復するためには、腱付着部を元の位置に縫着することが重要と考えられた。

  (公社)日本整形外科学会, Sep. 2010, 日本整形外科学会雑誌, 84(9) (9), 562 - 566, Japanese


• ヒト腱板組織由来細胞の軟骨分化の可能性

  名倉 一成, 国分 毅, 西本 華子, 坂田 亮介, 乾 淳幸, 牧野 健

  (一社)日本肩関節学会, Sep. 2010, 肩関節, 35(1) (1), 49 - 49, Japanese


• 化膿性肩関節炎に対する鏡視下デブリドマンと開放性ドレナージ

  国分 毅, 名倉 一成, 乾 淳幸, 坂田 亮介, 西本 華子, 牧野 健

  (一社)日本肩関節学会, Sep. 2010, 肩関節, 35(1) (1), 90 - 90, Japanese


• ヒト断裂腱板組織由来細胞の軟骨分化についての検討

  名倉 一成, 国分 毅, 牧野 健, 西本 華子, 坂田 亮介, 乾 淳幸, 池田 里砂, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1193 - S1193, Japanese


• 生体吸収性scaffoldを用いた骨軟骨修復におけるvascular endotherial growth factor局在の検討

  坂田 亮介, 藤岡 宏幸, 牧野 健, 国分 毅, 名倉 一成, 豊川 成和, 乾 淳幸, 兼子 博章, 佐竹 真, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1194 - S1194, Japanese


• 肩腱板断裂に対するスーチャーブリッジ法による鏡視下腱板修復術

  国分 毅, 名倉 一成, 牧野 健, 池田 里砂, 豊川 成和, 乾 淳幸, 坂田 亮介, 西本 華子, 藤田 健司

  腱板断裂サイズ3cm以下の完全断裂に対する鏡視下修復術をスーチャーブリッジ法で行い術後6ヵ月以上観察しえた11例の治療成績について調査し、同修復術を重層固定法で行った10例の成績と群間比較した。その結果、以下の評価項目すべてにおいて有意な群間差は認められなかった。1)術後3ヵ月・6ヵ月時のJOAスコア。2)術後3ヵ月・6ヵ月時の関節可動域。3)術後6ヵ月時のMRIによるcuff integrity(菅谷らの分類)。

  (一社)日本肩関節学会, Aug. 2010, 肩関節, 34(3) (3), 833 - 836, Japanese


• 成人上腕骨顆部骨折に対するLCP Distal Humerus Plateの使用経験

  乾 淳幸, 牧野 健, 国分 毅, 名倉 一成, 坂田 亮介, 西本 華子, 黒坂 昌弘

  (一社)日本骨折治療学会, Jul. 2010, 骨折, 32(Suppl.) (Suppl.), S203 - S203, Japanese


• 高齢者大腿骨頸部骨折に対し、股関節ブロックおよび局所麻酔にて骨接合術を施行した症例の検討

  乾 淳幸, 高橋 完靖, 三輪 雅彦, 新倉 隆宏, 李 相亮, 大江 啓介, 黒坂 昌弘

  (一社)日本骨折治療学会, Jul. 2010, 骨折, 32(Suppl.) (Suppl.), S250 - S250, Japanese


• 高齢者上腕骨遠位部骨折に対するLCP Distal Humerus Plateの使用経験

  西本 華子, 牧野 健, 乾 淳幸, 国分 毅, 名倉 一成, 黒坂 昌弘

  著者らは高齢者上腕骨遠位部骨折に対するLCP Distal Humerus Plate(DHP)の使用経験を報告した。対象は2007年9月〜2009年9月までにDHPを用いて骨接合術を行った8例(全例女性、平均年齢82.5歳)であった。受傷機転は転倒7例、交通事故1例で、骨折型はAO分類でA2:5例、B2:1例、C2:2例であった。術後平均経過観察期間9.6ヵ月の結果、1)全例で骨癒合が得られ、骨癒合期間は平均4.1ヵ月であった。2)最終時の肘関節可動域(平均)は伸展-28.8°、屈曲123°、JOA scoreは平均75.6点であった。3)合併症はplateの皮下突出による痛みが2例、尺骨神経領域のしびれが1例であった。

  (一社)中部日本整形外科災害外科学会, Jul. 2010, 中部日本整形外科災害外科学会雑誌, 53(4) (4), 905 - 906, Japanese


• DTJ screwを用いた鏡視下骨性バンカート修復の1例

  国分 毅, 名倉 一成, 牧野 健, 乾 淳幸, 坂田 亮介, 西本 華子, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2010, JOSKAS, 35(4) (4), 373 - 373, Japanese


• 高齢者上腕骨遠位部骨折に対するLCP Distal Humerus Plateの使用経験

  西本 華子, 牧野 健, 乾 淳幸, 国分 毅, 名倉 一成, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2010, 中部日本整形外科災害外科学会雑誌, 53(春季学会) (春季学会), 116 - 116, Japanese


• 手掌部動脈瘤の1例

  西本 華子, 牧野 健, 国分 毅, 名倉 一成, 乾 淳幸, 坂田 亮介, 黒坂 昌弘, 藤岡 宏幸

  (一社)中部日本整形外科災害外科学会, Mar. 2010, 中部日本整形外科災害外科学会雑誌, 53(2) (2), 480 - 480, Japanese


• 腱組織再生に適した生体吸収性高分子scaffoldの形状の検討

  乾 淳幸, 国分 毅, 牧野 健, 名倉 一成, 豊川 成和

  (一社)日本手外科学会, Mar. 2010, 日本手の外科学会雑誌, 27(1) (1), S300 - S300, Japanese


• 指屈筋腱pulley切除が指屈曲角度に与える影響 屍体手を用いた観察

  乾 淳幸, 牧野 健, 国分 毅, 坂田 亮介, 黒坂 昌弘

  (一社)日本手外科学会, Mar. 2010, 日本手の外科学会雑誌, 27(1) (1), S310 - S310, Japanese


• 鏡視下生検術が有用であったリウマチ肩の1例

  名倉 一成, 国分 毅, 坂田 亮介, 乾 淳幸, 豊川 成和, 藤岡 宏幸, 黒坂 昌弘

  約1年前から右肩関節痛を自覚し、右上腕骨頭の異常陰影を指摘されていた60歳女性症例について検討した。右肩関節に腫脹と軽度の熱感を認めた。可動域制限はあったが、インピンジメントサイン・棘上筋・棘下筋の負荷テストは陰性であった。朝のこわばりや他関節の疼痛、および腫脹はみられなかった。単純X線像で上腕骨頭と関節窩の骨破壊像の進行を認めた。MRIでは、T1強調像で低信号、T2強調像で不均一な高信号を呈す上腕骨頭の異常陰影や関節水腫を認めた。C反応性タンパク(CRP):0.47mg/dl、リウマトイド因子(RF):陰性、赤沈:22mm(1h)、抗CCP抗体:陽性であった。各種細菌培養はすべて陰性であった。病理診断目的で関節鏡視下滑膜切除を行った。術中、滑膜増殖と上腕骨頭部の破壊を、病理組織検査では炎症細胞の浸潤を認め、RAと診断した。炎症所見が乏しい肩関節初発のRA診断には、抗CCP抗体や画像診断に加え、関節鏡視下の滑膜生検術が有用であると考えられた。

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2010, JOSKAS, 35(1) (1), 236 - 237, Japanese


• 小児上腕骨外顆骨折の治療

  藤岡 宏幸, 田中 寿一, 吉矢 晋一, 乾 淳幸, 黒坂 昌弘, 辻 充男

  小児上腕骨外顆骨折13例(平均5.3歳)について検討した。新鮮骨折はWadsworth分類I型6例、II型2例、III型3例の計11例で、偽関節は受傷後1年および9年経過例の計2例であった。新鮮骨折のI型6例はギプス包帯固定にて保存的治療とし、II型2例は徒手整復および経皮的鋼線刺入を施行し、III型3例は観血的骨接合術を行った。偽関節例は、受傷直後に観血的骨接合術を行ったが骨癒合が得られなかった1例、初期治療時に保存的治療を行ったが骨癒合が得られず9年後に受診した1例で、腸骨移植および引き寄せ締結法にて骨接合術を行った。その結果、新鮮例および偽関節例の全例で骨癒合が得られ、骨の成長障害や肘関節可動域制限などもなく、経過良好であった。

  (一社)日本骨折治療学会, Feb. 2010, 骨折, 32(1) (1), 39 - 42, Japanese


• 上腕骨通顆骨折に対するLCP Distal Humerus Plateの使用経験

  乾 淳幸, 牧野 健, 国分 毅, 名倉 一成, 豊川 成和, 坂田 亮介, 西本 華子

  日本肘関節学会, Jan. 2010, 日本肘関節学会雑誌, 17(1) (1), S62 - S62, Japanese


• 上腕骨骨折に合併した橈骨神経麻痺症例の検討

  乾 淳幸, 藤岡 宏幸, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 黒坂 昌弘

  上腕骨骨折に合併した橈骨神経麻痺症例11例(男性8例、女性3例、受傷時年齢5〜74歳、平均年齢25歳)について検討した。骨折に対しては1例に保存的治療、10例に骨接合術が行われ、神経障害に対する治療としては早期に神経の展開を行ったのは4例(早期展開群)、経過観察を行ったのは7例(経過観察群)であった。その結果、1)早期展開群では3例に神経剥離が行なわれ、麻痺の完全回復までの平均期間は3.7ヵ月であった。一方、経過観察群では5例が麻痺の回復傾向を認めず、受傷後平均2.7ヵ月の時点で神経を展開し、4例に神経剥離、1例に神経移植が行なわれた。2)経過観察群で神経剥離を行った4例は、神経回復までに平均8ヵ月を要し、完全回復に至らない症例もみられた。また、神経移植症例は早期展開群、経過観察群ともMMT2以下と回復不良であったため、後日腱移行術が行なわれた。

  (一社)日本骨折治療学会, Dec. 2009, 骨折, 31(4) (4), 702 - 704, Japanese


• 層状構造の生体吸収性高分子scaffoldによる腱・靱帯組織再生の試み

  乾 淳幸, 国分 毅, 藤岡 宏幸, 名倉 一成, 池田 里砂, 豊川 成和, 坂田 亮介, 黒坂 昌弘, 小寺 賢, 西野 孝

  (公社)日本整形外科学会, Aug. 2009, 日本整形外科学会雑誌, 83(8) (8), S1057 - S1057, Japanese


• 生体吸収性ナノファイバーscaffoldを用いた培養細胞を用いない骨軟骨修復

  豊川 成和, 藤岡 宏幸, 牧野 健, 国分 毅, 名倉 一成, 池田 里砂, 乾 淳幸, 坂田 亮介, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2009, 日本整形外科学会雑誌, 83(8) (8), S1191 - S1191, Japanese


• 生体吸収性高分子scaffold単独移植による軟骨再生 気孔率の違いによる効果について

  池田 里砂, 藤岡 宏幸, 牧野 健, 国分 毅, 名倉 一成, 豊川 成和, 乾 淳幸, 坂田 亮介, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2009, 日本整形外科学会雑誌, 83(8) (8), S1191 - S1191, Japanese


• ポリ-L-乳酸(PLLA)を用いたscaffoldによる肩腱板再生の検討

  乾 淳幸, 国分 毅, 藤岡 宏幸, 名倉 一成, 豊川 成和

  ポリ-L-乳酸(PLLA)を用いた新しい足場を兎棘下筋腱欠損モデルに移植して修復し、肩腱板再生における効果を検討した。足場として、PLLA繊維を使用し表面が平滑で、裏面がパイル状のシート(PLLAシート)を用いた。兎の背筋筋膜下にPLLAシートを移植した実験では、シートの平滑側には膠原線維の増生を殆ど認めなかったが、起伏に富むパイル側ではシートの周囲から深部にまで青染する膠原線維の増生を認めた。さらに、このPLLAシートを二重合わせとした足場を頼下筋腱欠損部へ移植した実験では表面の平滑な部分では癒着が少なく、内部のパイル状構造には良好に細胞が侵入して接着した。棘下筋腱欠損部への移植実験において、欠損部の中央部分には線維様組織が再生している像が確認されたが、腱付着部には正常のenthesisと同様の線維軟骨を介した再生は認めなかった。腱板組織の再生に有利な可能性が示唆された。

  (一社)日本肩関節学会, Aug. 2009, 肩関節, 33(3) (3), 729 - 732, Japanese


• 鏡視下腱板修復術の術後成績 術前拘縮の影響について

  国分 毅, 名倉 一成, 豊川 成和, 乾 淳幸, 坂田 亮介, 藤岡 宏幸

  2005年9月〜2008年1月にMRIで腱板断裂と診断し、3ヵ月以上の保存療法に抵抗した症例に鏡視下腱板修復術(ARCR)を施行し、術後6ヵ月以上経過観察できた27肩(男11肩・女16肩、39〜83歳・平均63.3歳)を対象に、術前の拘縮の有無で2群に分け術後成績を検討した。2群は術前に拘縮のあった拘縮あり群11肩、なかった拘縮なし群16肩とした。JOAスコアは術前・術後6ヵ月で拘縮あり群60.8±11.4点・87.0±8.7点、拘縮なし群70.6±12.4点・89.6±7.6点と両群とも有意に改善した。可動域の項目でも拘縮あり群のスコアは有意に改善し、術前にみられた2群間の有意差は6ヵ月でみられなくなった。疼痛と機能の各項目では、術前、術後で両群間に有意差は認めなかったが両群ともスコアは有意に改善していた。

  (一社)日本肩関節学会, Jul. 2009, 肩関節, 33(2) (2), 389 - 392, Japanese


• 遠位橈尺関節障害に対する関節形成術

  藤岡 宏幸, 国分 毅, 坂田 亮介, 乾 淳幸, 黒坂 昌弘, 山崎 京子

  Sauve-Kapandji法で関節形成術を行った遠位橈尺関節障害(DRUJ)6例の治療成績を報告した。男性3例、女性3例、手術時年齢56〜78歳、術後観察期間は6ヵ月〜1年であった。手術方法は、手関節背尺側より皮切を行い、尺骨茎状突起の遠位端より約15cmmの位置で骨切りし、さらに最初の骨切りより約15mm近位の位置で骨切りを追加して骨切除を行い、骨欠損を作製した。次にDRUJの関節軟骨を橈骨側・尺骨側とも掻爬し、尺骨遠位部を橈骨に内固定した。内固定にはcannulated screwを用いた。術後の手関節可動域平均値は、背屈47°(術前53°)、掌屈43°(術前49°)、回内87°(術前83°)、回外74°(術前78°)であり、術前後で大きな変化はなかった。術後の握力平均値は28.4kg(術前27.8kg)であり、術前後で大きな変化はなかった。最終観察時には全例で手関節の運動時痛が消失していた。

  (一社)中部日本整形外科災害外科学会, May 2009, 中部日本整形外科災害外科学会雑誌, 52(3) (3), 623 - 624, Japanese


• 骨接合術後に偽関節となった舟状骨骨折の検討

  乾 淳幸, 藤岡 宏幸, 国分 毅, 名倉 一成, 豊川 成和, 黒坂 昌弘

  初回治療で骨接合術を行ったが偽関節となった舟状骨骨折に対して再度骨接合術(サルベージ手術)を行った5例6手の治療成績を報告した。男性4例、女性1例、年齢19〜39歳、初回手術からサルベージ手術までの間隔は平均13.6ヵ月であった。サルベージ手術の方法は、初回手術の内固定材料を抜釘、偽関節部を掻爬の後、腸骨移植を行い、抜釘後のscrew holeには皮質骨の骨釘移植を行った。内固定にはDTJ screwまたはmini Herbert screwを用いた。後療法として8週間のギプス固定を行い、低出力超音波パルスを併用した。全例で骨癒合が得られ、手関節の平均可動域は掌屈83°(術前59°)、背屈75°(術前59°)に改善、握力も健側比平均93%(術前71%)に改善した。代表例1例を提示した。

  (一社)中部日本整形外科災害外科学会, May 2009, 中部日本整形外科災害外科学会雑誌, 52(3) (3), 631 - 632, Japanese


• Freiberg病に対する自家骨軟骨移植術の一例

  藤岡 宏幸, 名倉 一成, 国分 毅, 豊川 成和, 乾 淳幸, 坂田 亮介, 牧野 健, 黒坂 昌弘, 戸祭 正喜, 吉矢 晋一

  (一社)日本足の外科学会, May 2009, 日本足の外科学会雑誌, 30(1) (1), S126 - S126, Japanese


• 骨接合術と骨軟骨移植を併用して治療した距骨骨軟骨傷害の一例

  藤岡 宏幸, 国分 毅, 名倉 一成, 豊川 成和, 乾 淳幸, 坂田 亮介, 黒坂 昌弘

  15歳男。患者はサッカー中に誘因なく右足関節痛が生じた。X線正面像では距骨外側に骨の透過像がみられ、側面像では距骨前外側の分離した骨軟骨片が認められた。MRI所見を含め、距骨骨軟骨傷害Anderson分類StageIIIと診断され、手術を施行したところ、距骨前外側に長径3cm、横径2cm程度の遊離した骨軟骨片が確認された。また母床には骨硬化と骨嚢腫が認められた。そこで、遊離した骨軟骨を2本のDTJ screwで固定し、更に骨釘移植の効果を狙って、大腿骨顆部から採取した直径4.5mmの骨軟骨柱を移植した。その結果、術後4ヵ月でほぼ元のスポーツ活動レベルに復帰、術後8ヵ月のX線では骨軟骨片の癒合も確認された。

  (一社)日本足の外科学会, May 2009, 日本足の外科学会雑誌, 30(2) (2), 1 - 4, Japanese


• 【手根不安定症の治療戦略】SLAC wristとSNAC wrist

  藤岡 宏幸, 国分 毅, 名倉 一成, 豊川 成和, 乾 淳幸, 坂田 亮介, 黒坂 昌弘

  (株)メジカルビュー社, Apr. 2009, 関節外科, 28(4) (4), 516 - 521, Japanese


• スーチャーブリッジ法による鏡視下肩腱板修復術の検討

  国分 毅, 名倉 一成, 藤岡 宏幸, 豊川 成和, 乾 淳幸, 坂田 亮介, 藤田 健司, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2009, 日本整形外科学会雑誌, 83(3) (3), S446 - S446, Japanese


• 層状構造の生体吸収性高分子(PLLA)scaffoldによる腱組織再生の試み

  乾 淳幸, 国分 毅, 藤岡 宏幸, 名倉 一成, 黒坂 昌弘

  (一社)日本手外科学会, Mar. 2009, 日本手の外科学会雑誌, 26(1) (1), S154 - S154, Japanese


• 手根管症候群重症例に対する手掌刺激による複合筋活動電位の検討

  金谷 貴子, 藤岡 宏幸, 黒坂 昌弘, 乾 淳幸, 山崎 京子

  (一社)日本手外科学会, Mar. 2009, 日本手の外科学会雑誌, 26(1) (1), S268 - S268, Japanese


• 舟状骨骨折偽関節に対する腸骨移植を併用した骨接合術の治療成績

  豊川 成和, 藤岡 宏幸, 国分 毅, 名倉 一成, 乾 淳幸, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2009, 中部日本整形外科災害外科学会雑誌, 52(春季学会) (春季学会), 157 - 157, Japanese


• 骨接合術にて骨癒合が得られなかった舟状骨骨折に対するサルベージ手術の検討

  藤岡 宏幸, 国分 毅, 名倉 一成, 豊川 成和, 乾 淳幸, 黒坂 昌弘, 蔭山 敬久, 戸祭 正喜, 奥野 宏昭, 田中 寿一, 吉矢 晋一

  (公社)日本整形外科学会, Feb. 2009, 日本整形外科学会雑誌, 83(2) (2), S87 - S87, Japanese


• 生体吸収性高分子scaffoldの気孔率が軟骨修復に与える影響

  藤岡 宏幸, 池田 里砂, 名倉 一成, 国分 毅, 豊川 成和, 乾 淳幸, 坂田 亮介, 黒坂 昌弘, 兼子 博章, 佐竹 真

  (一社)日本移植学会, Feb. 2009, 移植, 44(1) (1), 142 - 142, Japanese


• 小児上腕骨顆上骨折の新鮮例の治療経験

  藤岡 宏幸, 国分 毅, 乾 淳幸, 黒坂 昌弘, 平中 崇文, 辻 充男

  著者らは小児上腕骨顆上骨折新鮮例の治療成績を検討した。対象は1995〜2006年までに治療した小児上腕骨顆上骨折66例(男児33例、女児33例、平均年齢6.1歳)であった。骨折型は阿部の分類で1型29例、2型1例、3型9例、4型27例で、治療は1型全例に徒手整復ギプス包帯固定が行われ、他は観血的治療が施行された。1)Flynnによる骨折治療評価ではcosmetic factorはexcellent:60例、good:6例、functional factorはexcellent:62例、good:4例と良好な成績であった。2)術前に神経血管障害を4型の27例中8例(全体の12%、4型の30%)に認められ、上腕動脈の血行障害3例中2例は骨折整復で回復し、1例は血栓除去術が施行された。一方、神経麻痺5例中3例は保存的に治療し、2例は神経剥離術が行われた。尚、8例全例で後遺症なく良好な回復が確認された。

  (一社)日本骨折治療学会, Feb. 2009, 骨折, 31(1) (1), 118 - 120, Japanese


• 小児上腕骨外顆骨折の新鮮例の治療経験

  藤岡 宏幸, 国分 毅, 名倉 一成, 豊川 成和, 乾 淳幸, 坂田 亮介, 黒坂 昌弘, 平中 崇文, 辻 充男

  日本肘関節学会, Jan. 2009, 日本肘関節学会雑誌, 16(1) (1), S50 - S50, Japanese


• Monteggia骨折を来たしたpycnodysostosisの1例

  名倉 一成, 藤岡 宏幸, 国分 毅, 坂田 亮介, 乾 淳幸, 豊川 成和, 森 裕之, 三谷 誠, 鍋島 祐次, 黒坂 昌弘

  日本肘関節学会, Jan. 2009, 日本肘関節学会雑誌, 16(1) (1), S78 - S78, Japanese


• Panner病の一例

  坂田 亮介, 藤岡 宏幸, 国分 毅, 名倉 一成, 豊川 成和, 乾 淳幸, 黒坂 昌弘

  日本肘関節学会, Jan. 2009, 日本肘関節学会雑誌, 16(1) (1), S81 - S81, Japanese


• Pyogenic granulomaの1例

  布居 理沙, 藤岡 宏幸, 国分 毅, 名倉 一成, 乾 淳幸, 豊川 成和, 坂田 亮介, 秋末 敏宏, 岸本 健太, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Jan. 2009, 中部日本整形外科災害外科学会雑誌, 52(1) (1), 253 - 253, Japanese


• 手根管開放術後1年における電気生理学的回復についての検討

  金谷 貴子, 藤岡 宏幸, 乾 淳幸, 黒坂 昌弘, 山崎 京子

  2004〜2006年に手根管症候群(CTS)で手根管開放術を施行した81手(男13名、女60名、年齢39〜92歳)を対象に電気生理学的回復を短母指外転筋遠位潜時(DML)と感覚神経伝導速度(SCV)を用いて検討した。電気生理伝導度は1期:正常、2期:DML遅延+SCV正常、3期:DML遅延+SCV低下、4期:DML遅延+SCV測定不能、5期:DML、SCV測定不能と分類した。術前分類は2期2手、3期13手、4期33手、5期33手で4期と5期で約80%を占め、各期での年齢に有意差は認めなかった。術後1年の分類は1期22手、2期33手、3期15手、4期9手、5期2手で、有意に2期が多く、また1、2期を合わせると約79%となり、術前に比べ改善を認めた。術前2期は術後が1期7手、2期5手、3期のままの1手もDMLは改善し全例でDML、SCVの両方または片方が改善し、12手93%が1期以上改善した。術前は1期3手、2期14手、3期7手、4期7手、5期2手で、31手94%が1期以上改善した。ただし、5期では1、2期への回復は3、4期に比べ有意に劣り、術後1年で3、4期に留まったものが多かったことは重症度が進むにつれて軸索変性の占める割合は増加していったものと推測された。

  (一社)日本手外科学会, Dec. 2008, 日本手の外科学会雑誌, 25(3) (3), 197 - 200, Japanese


• 小児化膿性肘関節炎の1例

  豊川 成和, 国分 毅, 乾 淳幸, 名倉 一成, 藤岡 宏幸

  11ヵ月男児。突然泣き出し左肘を動かさなくなり、翌日発熱と左肘腫脹が出現した。受診時、左肘関節前方に腫脹・硬結があり、血液検査で炎症反応を認め、MRIで肘関節内にT1強調像で等信号、T2強調像で高信号の関節液の貯留を疑わせる領域を認めた。関節液穿刺で黄褐色混濁液を採取したため、化膿性肘関節炎を疑い抗生剤投与を行ったが改善なく、全身麻酔下に関節鏡視下洗浄術を行った。橈骨頭の外側を約1cm縦切開し、鈍的に皮下組織を剥離した後、関節鏡で関節内を観察した。関節内の関節軟骨は正常であったが、滑膜は関節内に軽度増生していた。鏡視を行いながら関節内を関節鏡用灌流液で洗浄することで、関節内に存在していたdebrisの除去を確認した。入院時の血液および関節液培養検査ではインフルエンザ桿菌が検出された。術後は抗生剤投与を行い、炎症所見および症状は消失し退院となり、術後6ヵ月の現在、再発は認めていない。

  日本肘関節学会, Dec. 2008, 日本肘関節学会雑誌, 15(2) (2), 163 - 165, Japanese


• Clinical Outcome of Arthroscopic Repair in Rotator Cuff Tears with Shoulder Stiffness

  KOKUBU Takeshi

  25 Oct. 2008, 関節鏡, 33(3) (3), 67 - 67, Japanese


• 観血的治療を要したMTP関節脱臼の3例

  乾 淳幸, 櫻井 敦志, 澤村 悟, 川北 晃平

  症例1(19歳男性)。バイクにて転倒受傷し、単純X線で第4・5MTP関節背側脱臼および第3中骨頸部骨折と診断された。症例2(52歳男性)。バイクにて転倒受傷し、単純X線・CTにて第3・4・5MTP関節背側脱臼と診断された。症例3(33歳女性)。自動車事故にて両大腿骨骨折等の多発外傷を受傷し、各々に骨接合術を行ったが、受傷後6ヵ月に前足部の変形を認め、第2MTP関節陳旧性脱臼と診断された。いずれの症例も徒手整復不可能で、観血的整復を行った結果、新鮮例の症例1、2はそれぞれ術後14ヵ月、術後2ヵ月で愁訴を認めず、成績良好であった。だが、陳旧例の症例3は術後に関節症変化が進行し、歩行時痛の持続を認め、成績不良であった。3例とも手術は背側進入で行ったが、整復阻害因子は深横中足靱帯・底側板・屈筋腱であった。

  (一社)日本骨折治療学会, Oct. 2008, 骨折, 30(3) (3), 391 - 393, Japanese


• 若年スポーツ選手に生じた橈骨遠位端骨折後の変形に対する治療経験

  藤岡 宏幸, 国分 毅, 名倉 一成, 豊川 成和, 乾 淳幸, 坂田 亮介, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2008, 日本臨床スポーツ医学会誌, 16(4) (4), S141 - S141, Japanese


• 小指PIP関節不安定症に対する靱帯再建術の一例

  藤岡 宏幸, 国分 毅, 名倉 一成, 豊川 成和, 乾 淳幸, 坂田 亮介, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2008, 日本臨床スポーツ医学会誌, 16(4) (4), S141 - S141, Japanese


• 鏡視下腱板修復術の術後成績 術前拘縮の影響について

  国分 毅, 名倉 一成, 豊川 成和, 乾 淳幸, 坂田 亮介, 藤岡 宏幸

  (一社)日本肩関節学会, Oct. 2008, 肩関節, 33(1) (1), 72 - 72, Japanese


• ポリ-L-乳酸(PLLA)を用いたscaffoldによる肩腱板再生の検討

  乾 淳幸, 国分 毅, 藤岡 宏幸, 名倉 一成, 豊川 成和

  (一社)日本肩関節学会, Oct. 2008, 肩関節, 33(1) (1), 101 - 101, Japanese


• 上腕骨顆部・顆上部骨折に合併した神経麻痺症例の検討

  乾 淳幸, 藤岡 宏幸, 国分 毅, 豊川 成和, 池田 里砂, 黒坂 昌弘, 金谷 貴子

  (一社)日本手外科学会, Sep. 2008, 日本手の外科学会雑誌, 24(5) (5), 825 - 825, Japanese


• 骨接合術後に偽関節になった舟状骨骨折の検討

  乾 淳幸, 藤岡 宏幸, 国分 毅, 名倉 一成, 豊川 成和, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Sep. 2008, 中部日本整形外科災害外科学会雑誌, 51(秋季学会) (秋季学会), 172 - 172, Japanese


• 【野球肘の診断と治療】後方型野球肘に対する治療

  藤岡 宏幸, 国分 毅, 名倉 一成, 豊川 成和, 乾 淳幸, 黒坂 昌弘

  (株)メジカルビュー社, Aug. 2008, 関節外科, 27(8) (8), 1084 - 1088, Japanese


• 生体吸収性高分子(PLLA)を使用したcell-free scaffoldによる肩腱板修復の試み

  乾 淳幸, 国分 毅, 藤岡 宏幸, 豊川 成和, 名倉 一成, 黒坂 昌弘, 小寺 賢, 西野 孝

  (公社)日本整形外科学会, Aug. 2008, 日本整形外科学会雑誌, 82(8) (8), S945 - S945, Japanese


• Enthesisの基礎 構造と機能 EnthesisにおけるX型コラーゲンの発現とその意義

  藤岡 宏幸, 国分 毅, 名倉 一成, 豊川 成和, 乾 淳幸, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2008, 日本整形外科学会雑誌, 82(8) (8), S1140 - S1140, Japanese


• 上腕骨外顆偽関節に対する骨接合術症例の検討

  乾 淳幸, 藤岡 宏幸, 国分 毅, 豊川 成和, 黒坂 昌弘

  当科で2001〜2006年に上腕骨外顆偽関節に対して骨接合術を行った3例の成績を報告した。全例男性、年齢はそれぞれ4歳・11歳・36歳、受傷から手術までの期間は1〜33年であった。手術方法は、小児2例には8の字締結法、成人1例にはDTJ screwによる接合術を行い、全例に腸骨移植を併施した。治療成績は全例で骨癒合が得られ、小児例では2例とも可動域制限は認めなかったが、成人例では20°の伸展制限を認めた。

  (一社)中部日本整形外科災害外科学会, Jul. 2008, 中部日本整形外科災害外科学会雑誌, 51(4) (4), 701 - 702, Japanese


• Treatment for Periprosthetic Fractures Following Total Hip Arthroplasty and Hemiarthroplasty

  川上洋平, 澤村悟, 櫻井敦志, 島直子, 川北晃平, 乾淳幸, 矢野智則, 織邊隆

  (株)医学書院, Jul. 2008, 臨床整形外科, 43(7) (7), 663 - 667, Japanese


• 小児上腕骨顆上骨折の新鮮例の治療経験

  藤岡 宏幸, 乾 淳幸, 国分 毅, 豊川 成和, 新倉 隆宏, 三輪 雅彦, 黒坂 昌弘, 平中 崇文, 辻 充男, 坂井 宏成

  (一社)日本骨折治療学会, May 2008, 骨折, 30(Suppl) (Suppl), S48 - S48, Japanese


• 上腕骨骨折に合併した橈骨神経麻痺症例の検討

  乾 淳幸, 藤岡 宏幸, 国分 毅, 豊川 成和, 三輪 雅彦, 酒井 良忠, 黒坂 昌弘

  (一社)日本骨折治療学会, May 2008, 骨折, 30(Suppl) (Suppl), S96 - S96, Japanese


• 骨接合術と骨軟骨移植を併用して治療した距骨骨軟骨傷害の一例

  藤岡 宏幸, 国分 毅, 名倉 一成, 豊川 成和, 乾 淳幸, 黒坂 昌弘

  (一社)日本足の外科学会, May 2008, 日本足の外科学会雑誌, 29(1) (1), S79 - S79, Japanese


• 上腕骨外顆偽関節に対する骨接合術症例の検討

  乾 淳幸, 藤岡 宏幸, 国分 毅, 豊川 成和, 池田 里砂, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2008, 中部日本整形外科災害外科学会雑誌, 51(春季学会) (春季学会), 77 - 77, Japanese


• 手根管開放術後一年における電気生理学的回復についての検討

  金谷 貴子, 藤岡 宏幸, 乾 淳幸, 黒坂 昌弘, 山崎 京子

  (一社)日本手外科学会, Mar. 2008, 日本手の外科学会雑誌, 25(1) (1), S35 - S35, Japanese


• ラット下肢同種移植における抗αβ-T CELLモノクローナル抗体とFK506の短期投与による免疫学的寛容獲得について

  金谷 貴子, 藤岡 宏幸, LanzettaMarco, 国分 毅, 乾 淳幸

  (一社)日本手外科学会, Mar. 2008, 日本手の外科学会雑誌, 25(1) (1), S70 - S70, Japanese


• 小児Monteggia骨折の治療経験

  藤岡 宏幸, 国分 毅, 豊川 成和, 乾 淳幸, 池田 里砂, 黒坂 昌弘, 名倉 一成, 小林 大介, 薩摩 真一

  (公社)日本整形外科学会, Feb. 2008, 日本整形外科学会雑誌, 82(2) (2), S143 - S143, Japanese


• 小児上腕骨外顆偽関節の治療経験

  藤岡 宏幸, 国分 毅, 豊川 成和, 乾 淳幸, 池田 里砂, 黒坂 昌弘, 新倉 隆宏, 金谷 貴子, 牧野 健

  日本肘関節学会, Jan. 2008, 日本肘関節学会雑誌, 15(1) (1), S72 - S72, Japanese


• 小児化膿性肘関節炎の1例

  豊川 成和, 国分 毅, 乾 淳幸, 池田 里砂, 藤岡 宏幸, 黒坂 昌弘, 名倉 一成

  日本肘関節学会, Jan. 2008, 日本肘関節学会雑誌, 15(1) (1), S80 - S80, Japanese


• 骨折後の骨感染症に対する血管柄付き腓骨移植術

  藤岡 宏幸, 国分 毅, 豊川 成和, 乾 淳幸, 黒坂 昌弘, 牧野 健

  下肢の骨折後に発生した骨感染症に対して病巣掻爬ののち血管柄付き腓骨移植術を行った4例の成績を報告した。骨折の内訳は大腿骨骨折2例、脛骨骨折2例で、起炎菌は全例MRSAであった。全例で感染の鎮静化と骨癒合が得られたが、慢性骨髄炎に至っていた1例では術後2年時に感染が再燃した。一方、感染性偽関節と考えられた他の3例は術後3年以上経過しても感染の再燃はなかった。

  (一社)中部日本整形外科災害外科学会, Jan. 2008, 中部日本整形外科災害外科学会雑誌, 51(1) (1), 167 - 168, Japanese


• 尿道断裂を伴った骨盤骨折の3例

  乾 淳幸, 澤村 悟, 桜井 敦志, 島 直子, 川北 晃平

  症例1:33歳男。作業中にショベルカーが下腹部にあたり受傷した。左下腹部に開放創があり、両恥骨骨折、大腿骨骨幹部骨折、大腿動脈損傷を認め、逆行性尿道造影で尿道断裂を認めた。内視鏡的に尿道再建術と大腿動脈修復術を行い、骨盤骨折に対し保存的治療を行った。後日、大腿骨骨幹部骨折に対し骨接合術を行い、排尿障害なく転院となった。症例2:70歳男。落下した鉄板が下腹部に直撃し受傷した。両恥骨骨折と右仙骨骨折を認め、造影CTで膀胱周囲に大量の血腫を認め、循環動態不安定のため両内腸骨動脈塞栓術を行った。逆行性尿道造影で尿道断裂を認め、膀胱瘻造設と内視鏡的尿道再建術を行った。後方骨盤輪損傷も認めたため骨盤創外固定術を追加した。尿道狭窄による排尿困難のため泌尿器科的処置を複数回要したが、骨盤は骨癒合が得られ、独歩可能となった。症例3:46歳男。倒れてきた鉄材に下腹部を挟まれ受傷した。右下腹部に開放創があり、右恥坐骨骨折を認めた。循環動態が不安定で、造影CTで会陰部に血管外漏出を認めたため選択的動脈塞栓術を行った。逆行性尿道造影で尿道断裂を認めたため、膀胱瘻造設術と内視鏡的尿道再建術を行った。しかし、その後も血圧不安定で、再度の造影CTで同部位に血管外漏出を認め、動脈塞栓術を再施行した。創は開放創としたが、会陰部の壊死が進行し瘻孔を形成したため、人工肛門造設術を行った。

  (一社)中部日本整形外科災害外科学会, Nov. 2007, 中部日本整形外科災害外科学会雑誌, 50(6) (6), 1053 - 1054, Japanese


• 肘頭骨端線閉鎖不全の治療経験

  藤岡 宏幸, 国分 毅, 豊川 成和, 乾 淳幸, 久保 晴司, 黒田 良祐, 土井田 稔, 黒坂 昌弘, 藤田 健司

  (一社)日本臨床スポーツ医学会, Oct. 2007, 日本臨床スポーツ医学会誌, 15(4) (4), S150 - S150, Japanese


• 骨折後の骨感染症に対する血管柄付き腓骨移植術

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