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KOTERAZAWA Yasufumi
University Hospital / Gastrointestinal Surgery
Assistant Professor

Research activity information

■ Paper
  • Yukari Adachi, Takeru Matsuda, Sachiko Inubushi, Keisuke Yasuda, Ryota Ito, Naoto Shirakami, Takaaki Tachibana, Masaki Imai, Hiroki Kagiyama, Takao Tsuneki, Masayuki Ando, Masafumi Saito, Yutaka Sugita, Taro Ikeda, Yasufumi Koterazawa, Tomoaki Aoki, Hitoshi Harada, Yasunori Otowa, Naoki Urakawa, Hironobu Goto, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Robert M Hoffman, Yoshihiro Kakeji
    BACKGROUND/AIM: Extracellular vesicles (EVs), including exosomes, are abundant in body fluids, and EV surface proteins can be profiled as potential minimally invasive biomarkers. CD147 (EMMPRIN/Basigin) is a tumor-associated surface glycoprotein implicated in cancer progression. CD9 and CD63 are tetraspanin membrane proteins widely used as EV markers. The present study aimed to evaluate the clinical significance of serum EV subsets double-positive for CD9 and CD63, or for CD9 and CD147 in patients with colorectal cancer (CRC) before and after tumor resection. MATERIALS AND METHODS: Sixteen patients with CRC were recruited, and paired pre- and postoperative serum samples were analyzed for CD9+ CD63+ EVs and CD9+ CD147+ EVs. Serum EVs were quantified using the ExoCounter system with antibody-conjugated beads. CD147 expression in resected tumor tissue was analyzed by immunohistochemistry. RESULTS: CD9+ CD63+ EVs were significantly reduced in postoperative samples compared with preoperative samples (p=0.0151). CD9+ CD147+ EVs also showed a significant postoperative decrease (p=0.0186). CD147 immunostaining was positive in 13 out of 16 resected tumors (81.3%). In patients with CD147 negative tumors (n=3), serum CD9+ CD147+ EV levels were low at both pre- and postoperative time points and remained unchanged. CONCLUSION: Serum CD9+ CD63+ and CD9+ CD147+ EV subsets decreased after CRC surgery, supporting their potential utility as minimally invasive liquid biopsy biomarkers of postoperative tumor burden. Future prospective clinical trials will determine whether these EV subsets are indeed biomarkers of postoperative residual tumor.
    May 2026, Anticancer research, 46(5) (5), 2345 - 2352, English, International magazine
    Scientific journal

  • Yasufumi Koterazawa, Hironobu Goto, Tomoaki Aoki, Masayuki Ando, Yutaka Sugita, Taro Ikeda, Hitoshi Harada, Yasunori Otowa, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    BACKGROUND: Esophageal squamous cell carcinoma (ESCC) and hepatic cirrhosis (HC) share major risk factors, including alcohol consumption and smoking. Consequently, patients with HC exhibit an elevated incidence of ESCC. Although HC is widely recognized to contribute to poor prognosis following esophagectomy for ESCC, the underlying mechanisms remain poorly understood. This study aimed to investigate the association between hepatic fibrosis evaluated using the fibrosis-4 (FIB-4) index and postoperative outcomes among patients with ESCC undergoing esophagectomy. METHODS: We retrospectively analyzed 461 patients with ESCC who underwent minimally invasive esophagectomy at Kobe University Hospital. Hepatic fibrosis was evaluated using the FIB-4 index, which estimates liver fibrosis based on routine blood test parameters. Patients were stratified into two groups: fibrosis-positive (FIB-4 > 2.67) and fibrosis-negative (FIB-4 ≤ 2.67). RESULTS: Among patients with cT1 tumors, overall survival (OS) did not differ significantly between the two groups. However, among those with ≥cT2 tumors, the fibrosis-positive group showed significantly worse OS than the fibrosis-negative group (P = 0.0148). Additionally, the fibrosis-positive group had a significantly higher incidence of poor response to preoperative chemotherapy (P = 0.0075). Postoperative serum albumin levels were markedly lower at 3, 6, and 12 months in the fibrosis-positive group (P = 0.015, 0.043, and 0.0066, respectively). While albumin levels recovered to baseline in the fibrosis-negative group within 12 months, no such recovery was observed in the fibrosis-positive group. CONCLUSIONS: Preoperative hepatic fibrosis is associated with poor response to preoperative chemotherapy and prolonged postoperative malnutrition, contributing to poorer long-term survival outcomes among patients with ESCC undergoing minimally invasive esophagectomy.
    Jan. 2026, Annals of surgical oncology, 33(1) (1), 444 - 452, English, International magazine
    Scientific journal

  • Taro Ikeda, Shingo Kanaji, Naoki Urakawa, Hitoshi Harada, Yutaka Sugita, Masayuki Ando, Yasufumi Koterazawa, Tomoaki Aoki, Yasunori Otowa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    BACKGROUND/AIM: Previous studies demonstrated the safety of laparoscopic gastrectomy in patients with locally advanced gastric cancer. However, the feasibility of minimally invasive surgery (MIS) following neoadjuvant chemotherapy (NAC) for locally advanced gastric cancer remains unclear. To our knowledge, no previous study has conducted a comprehensive analysis that evaluated NAC and surgical approach simultaneously. This study aimed to assess the feasibility of MIS for locally advanced gastric cancer after NAC using a four-arm comparison. PATIENTS AND METHODS: This study retrospectively analyzed 174 patients who underwent gastrectomy at Kobe University Hospital between January 2011 and July 2024. The patients were categorized into four groups based on NAC and surgical approaches: No NAC/open surgery (n=63), no NAC/MIS (n=49), NAC/open surgery (n=20), and NAC/MIS (n=42). We compared surgical and survival outcomes among the four groups. RESULTS: Patients in the group treated with NAC/MIS experienced less blood loss, fewer transfusions, and a shorter hospital stay. Additionally, compared with the NAC/open (20%) and no NAC/MIS (6.1%) groups, the rate of severe postoperative complications (grade ≥III) was lowest in the group treated with NAC/MIS, with no incidence of pancreatic fistula. The R0 resection rate was highest (97.6%) in the group treated with NAC/MIS. Although 5-year relapse-free survival and overall survival were higher in the group treated with NAC/MIS, the differences were not statistically significant. CONCLUSION: This four-arm study suggests that minimally invasive surgery after NAC for locally advanced gastric cancer may be technically and oncologically safe.
    Dec. 2025, Anticancer research, 45(12) (12), 5557 - 5566, English, International magazine
    Scientific journal

  • Hironobu Goto, Yasufumi Koterazawa, Tomoaki Aoki, Yutaka Sugita, Taro Ikeda, Hitoshi Harada, Yasunori Otowa, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji
    PURPOSE: Minimally invasive esophagectomy (MIE) is the standard surgical procedure. Robot-assisted MIE (RAMIE) was developed to overcome the problems associated with conventional MIE. This study investigated whether or not standardizing surgical procedures for RAMIE using soft coagulation scissors and Maryland bipolar forceps could improve short-term outcomes. METHODS: This study included 130 patients who underwent RAMIE. Clinicopathological characteristics and surgical outcomes were compared before and after standardization by two expert surgeons as well as between the standardized and trainee groups. A cumulative sum control chart (CUSUM) was used to evaluate changes in operative time. RESULTS: The console time during the thoracic procedure was shorter in the standardized group than in the pre-standardized group (P < 0.001). The rate of recurrent laryngeal nerve palsy was lower in the standardized group than in the pre-standardized group (P = 0.039). No significant differences were observed between the standardized and trainee groups. In the standardized and trainee groups, CUSUM clearly indicated that the console time peak occurred in the 12th and 16th cases. CONCLUSIONS: Standardization of surgical procedures using an appropriate device for each surgical step could improve surgical outcomes in RAMIE. Furthermore, it may facilitate safer and more efficient surgical training.
    Nov. 2025, Surgery today, English, Domestic magazine
    Scientific journal

  • Takeru Matsuda, Kimihiro Yamashita, Hiroshi Hasegawa, Ryuichiro Sawada, Yasufumi Koterazawa, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Shingo Kanaji, Yoshihiro Kakeji
    PURPOSE: To examine the clinical impact of transanal total mesorectal excision (TaTME) for locally advanced rectal cancer after neoadjuvant chemoradiotherapy (NACRT). METHODS: This retrospective study included 91 patients undergoing surgery for rectal cancer after NACRT between 2011 and 2022. Among them, 24, 22, and 45 patients underwent open (Open), conventional laparoscopic (Lap), and TaTME surgeries, respectively. We compared their clinical outcomes. RESULTS: Operative time, blood loss, transfusion, morbidity, and hospital stay were significantly lower in the TaTME group than in the Open or Lap groups. The multivariate regression analyses identified only the TaTME approach as a significant factor for reducing morbidity. Both 3 yrear relapse-free survival (RFS) and local recurrence-free survival (LRFS) were significantly better in the TaTME group than in the Open or Lap groups (3 yr RFS: 94.7%, 80.4%, and 66.7%, and 3 yr LRFS: 100%, 90.5%, and 82.2% for the TaTME, Lap, and Open groups, respectively). Multivariate analyses of potential risk factors for recurrence identified body mass index, combined resection, and pathological stage, but not the TaTME approach, as significant predictors of recurrence. CONCLUSION: TaTME reduced morbidity significantly in patients with locally advanced rectal cancer undergoing NACRT, compared with open or laparoscopic surgery.
    Oct. 2025, Surgery today, 55(10) (10), 1373 - 1382, English, Domestic magazine
    Scientific journal

  • Yasufumi Koterazawa, Hironobu Goto, Tomoaki Aoki, Ryuichiro Sawada, Taro Ikeda, Hitoshi Harada, Yasunori Otowa, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Daisuke Miyawaki, Ryohei Sasaki, Yoshihiro Kakeji
    PURPOSE: Esophagectomy and chemoradiotherapy (CRT) are the mainstays of treatment for esophageal squamous cell carcinoma (ESCC). Older patients often do not receive full standard treatment due to physiological limitations. This study aimed to assess the long-term prognosis of surgery or non-surgery treatment for older patients with resectable ESCC. METHODS: This retrospective study included 114 patients who underwent esophagectomy (surgery group) and 65 patients who underwent CRT/radiotherapy (RT) (non-surgery group) at Kobe University Hospital. Propensity score matching was performed to identify matched patients in each tumor stage, including those with cT1N0 ESCC and cT1N-positive or cT2/3N-any ESCC. For cT1N0 ESCC, each group (surgery and non-surgery) had 14 patients. For cT1N-positive or cT2/3N-any ESCC, each group had 34 patients. RESULTS: After propensity score matching, for patients with cT1N0, the overall survival (OS) of the surgery group was significantly better than that of the non-surgery groups (p = 0.016). For cT1N-positive or cT2/3N-any patients, no significant differences were observed in OS between the two groups (p = 0.85). Before matching, in patients with cT1N0 ESCC, those who underwent RT alone had worse OS than patients who underwent surgery or CRT (p = 0.0003). In patients with cT1N-positive or cT2/3N-any ESCC, those who underwent RT alone or surgery alone had worse OS than those who underwent neoadjuvant chemotherapy plus surgery or CRT (p = 0.023). CONCLUSIONS: Patients who could not receive chemotherapy had poor survival. An appropriate treatment strategy should be considered, taking into account their general condition, especially their ability to receive chemotherapy.
    Oct. 2025, Esophagus : official journal of the Japan Esophageal Society, 22(4) (4), 546 - 556, English, Domestic magazine
    Scientific journal

  • Hitoshi Harada, Shingo Kanaji, Moe Tsuboi, Saki Nakatani, Satoko Tabuchi, Ikuko Yamamoto, Yutaka Sugita, Taro Ikeda, Yasufumi Koterazawa, Tomoaki Aoki, Yasunori Otowa, Naoki Urakawa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Michiko Takahashi, Yoshihiro Kakeji
    BACKGROUND & AIMS: Oral nutritional supplements (ONS) administered after gastrectomies can prevent postoperative weight loss. However, the amount of additional energy to be added to energy requirements after gastrectomy is unclear. This study aimed to clarify dietary energy intake and its association with weight loss in postgastrectomy patients. METHODS: We performed a single-center, single-arm, open-label, non-randomized clinical trial. Fifty patients with gastric cancer who underwent distal or total gastrectomy were included in this study. Until 3 months postoperatively, the patients continuously consumed ONS and their intake was recorded. Additionally, the patients took photos of their regular diets. Hospital visits were made every 2 weeks to investigate calorie intake (from regular diet plus ONS), physical findings, and nutritional status. The primary endpoint was the percentage of body weight loss (%BWL) at 3 months after gastrectomy. RESULTS: Data were available for 45 patients. %BWL was 7.5 ± 5.1 % at 3 months postoperatively. The group with ONS intake <200 kcal/day tended to show a lower %BWL; however, this was not significant. No correlation was observed between ONS and regular dietary calorie intake. The required calorie intake was 1588 ± 157 kcal/day. Calorie intake from regular diet alone and from regular diet plus ONS were 1330 ± 280 and 1487 ± 300 kcal/day, respectively. The sufficient group, whose total calorie intake met the requirements, had significantly reduced body weight loss, compared with the insufficient group. CONCLUSIONS: After gastrectomy, regular diet alone often fails to meet nutritional requirements, and ONS supplementation may reduce %BWL at 3 months postoperatively by correcting energy deficits. This study was registered with the University Hospital Medical Information Network Clinical Trial Registry (UMIN-CTR; UMIN000047451; https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000054111).
    Oct. 2025, Clinical nutrition ESPEN, 69, 449 - 457, English, International magazine
    Scientific journal

  • Yasufumi Koterazawa, Hironobu Goto, Tomoaki Aoki, Ryuichiro Sawada, Taro Ikeda, Hitoshi Harada, Yasunori Otowa, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji
    BACKGROUND: Several studies have compared robot-assisted minimally invasive esophagectomy (RAMIE) with conventional minimally invasive surgery (C-MIE). However, the anatomical factors that may make certain patients more suitable for RAMIE remains unclear. This study compared the surgical outcomes of RAMIE with those of C-MIE in patients with narrow mediastinum and left-shifted esophagus. METHODS: Between January 2017 and December 2023, 260 patients with esophageal squamous cell carcinoma (ESCC) who underwent MIE (C-MIE or RAMIE) at Kobe University Hospital were included in the study. We developed a new index to assess the narrow mediastinum and left-shifted esophagus at the tracheal bifurcation level using computed tomography imaging. Cox proportional hazards regression analyses were performed to identify the prognostic factors. RESULTS: Patients with a narrow mediastinum and left-shifted esophagus had a higher incidence of recurrent laryngeal nerve (RLN) palsy and fewer lymph nodes dissections than other patients (p = 0.026 and p = 0.051, respectively). In the entire cohort, the operative time in the RAMIE group was longer than that in the C-MIE group (< 0.0001). No significant differences in other variables, including RLN palsy, were observed between the two groups. Among patients with narrow mediastinum and left-shifted esophagus, RAMIE was associated with longer operative time and fewer lymph nodes dissected from the left and right sides of the upper mediastinum compared to C-MIE (p < 0.0001, 0.0001, and 0.0001, respectively). Regarding the RLN palsy, there was no significant difference (p = 0.79). CONCLUSIONS: There are challenges in performing RAMIE in patients with a narrow mediastinal and left-shifted esophagus. Therefore, establishing an effective procedure for these patients is important.
    Jul. 2025, Surgical endoscopy, 39(7) (7), 4156 - 4165, English, International magazine
    Scientific journal

  • Shingo Kanaji, Naoki Urakawa, Hitoshi Harada, Taro Ikeda, Yasufumi Koterazawa, Tomoaki Aoki, Ryuichiro Sawada, Yasunori Otowa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    Outcomes for advanced gastric cancer are improving with multidisciplinary treatment combining surgical resection and perioperative chemotherapy. In Asia, the standard of care for pathological Stage (pStage) II gastric cancer involves tegafur-gimeracil-oteracil potassium for 1 year postoperatively after gastrectomy with D2 lymph node dissection or capecitabine plus oxaliplatin for 6 months postoperatively. For pStage III gastric cancer, a combination of tegafur, gimeracil, and oteracil potassium combined with docetaxel remains the standard postoperative treatment. However, perioperative chemotherapy combined with surgery is being developed to further improve outcomes, similar to approaches in Europe. In addition, the perioperative use of molecularly targeted agents, such as trastuzumab, and immune checkpoint inhibitors, such as pembrolizumab, is expected to improve outcomes. Furthermore, improved chemotherapy outcomes have increased opportunities for surgical intervention in Stage IV gastric cancer, which was previously not indicated for surgery. In this article, we reviewed multidisciplinary treatments for Stage II-IV gastric cancer, combining surgery and chemotherapy.
    Jul. 2025, International journal of clinical oncology, 30(7) (7), 1268 - 1275, English, Domestic magazine
    Scientific journal

  • Taro Oshikiri, Hironobu Goto, Takashi Kato, Gosuke Takiguchi, Yasufumi Koterazawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Tetsu Nakamura, Sae Murakami, Yoshihiro Kakeji
    Esophageal cancer has an overall five-year survival rate of < 20%. The McKeown esophagectomy is invasive and carries a high risk of anastomotic leakage. Robust prospective outcome data comparing non-placement versus placement of a cervical drainage tube during McKeown esophagectomy are lacking. This study aimed to evaluate whether the placement of a cervical drainage tube is useful. In this randomized controlled, noninferiority trial, 106 patients with histologically proven, surgically resectable esophageal carcinoma were randomized to either placement or non-placement of a cervical drainage tube. The primary outcome was the percentage of Clavien-Dindo grade 2 or higher anastomotic leakage. Secondary outcomes included the duration from surgery to oral intake, hospital stay, and type and dose of analgesics used during hospitalization. Fifty-two and 54 patients were randomized to McKeown esophagectomy with non-placement and placement of a cervical drainage tube, respectively. There was no significant difference in anastomotic leakage rates between the non-placement (12/52 [23%]) and placement (13/54 [24%]) of drainage tube. However, non-inferiority was not demonstrated (risk difference, -0.100 [-0.17, 0.15]; p = 0.0591). There were no significant differences in the secondary outcome measures. Non-inferiority of nonplacement of a drainage tube around the cervical anastomosis after McKeown esophagectomy to placement of that was not demonstrated. Further large multicenter studies are needed.Trial registration: Japan Registry of Clinical Trials (identification number jRCT1052180016).
    Jun. 2025, Scientific reports, 15(1) (1), 19698 - 19698, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takashi Kato, Hironobu Goto, Michiko Takahashi, Yasufumi Koterazawa, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji
    BACKGROUND: Enteral nutrition therapy in the early postoperative period is essential for patients with esophageal cancer following esophagectomy. HINEX® E-gel LC is an oligomeric formula with various nutrients, including dietary fiber pectin. It is expected to reduce symptoms, such as diarrhea, resulting in improved adherence and a decreased rate of weight loss. However, no reports have examined the adherence to or efficacy of nutritional support therapy using HINEX® E-gel LC after esophagectomy. METHODS: This is a single-institution, single-arm phase II trial. We plan to recruit 32 patients with esophageal cancer who have undergone minimally invasive esophagectomy (MIE) and place an enteral feeding tube. Enteral feeding is to be initiated on the second postoperative day, and the patient is to remain on enteral feeding at 300 kcal/day after discharge. The primary endpoint is adherence to enteral nutrition with HINEX® E-gel LC for up to 2 months postoperatively. The secondary endpoint is the association between the adherence to HINEX® E-gel LC and each nutritional parameter, such as hematological examination, body weight, and psoas muscle. DISCUSSION: Although enteral nutrition is usually initiated in the early postoperative period after esophagectomy, the use of fat-containing digestive agents in the early postoperative period is a novel approach. To the best of our knowledge, this study is the first to evaluate the safety and nutritional status of early postoperative enteral nutrition using fat-containing digestive agents after MIE. Efficient nutritional support therapy using fat-containing digestive agents is expected to be especially useful after esophagectomy when oral intake is significantly decreased.
    May 2025, The Kobe journal of medical sciences, 71(2) (2), E50-E55, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Masayuki Ando, Takeru Matsuda, Kimihiro Yamashita, Hiroshi Hasegawa, Ryuichiro Sawada, Yasufumi Koterazawa, Naoki Urakawa, Hironobu Goto, Shingo Kanaji, Yoshihiro Kakeji
    PURPOSE: Conventional laparoscopic surgery (CLS) for rectal cancer may sometimes be difficult. Robot-assisted laparoscopic surgery (RALS) is expected to overcome these technical challenges of CLS and provide better short-term outcomes. However, previous randomized controlled trials indicated that the safety and feasibility of RALS compared to CLS remain controversial; therefore, we assessed the safety and feasibility of RALS for rectal cancer compared with CLS. METHODS: This study retrospectively reviewed 702 patients who had undergone anterior resection by CLS or RALS for rectal malignancies from January 2009 to December 2023. Among the patients, 313 and 75 were included in the CLS and RALS groups, respectively. Short- and midterm outcomes of the two groups were compared after performing propensity score matching analysis (PSM) to adjust for patient and tumor characteristics. RESULTS: A total of 140 and 70 patients in the CLS and RALS groups, respectively, were matched using PSM. The bleeding amount and C-reactive protein (CRP) levels on postoperative days 1 and 3 were significantly lower, the operation time was longer, and the postoperative hospital stay was significantly shorter in the RALS group than in the CLS group. The Kaplan-Meier curves for cause-specific survival, relapse-free survival, and the cumulative incidence of local recurrence demonstrated no difference between the two groups. CONCLUSION: RALS for rectal cancer provided superior outcomes to CLS in terms of the bleeding amount, postoperative CRP levels, and postoperative hospital stay. The midterm oncological outcomes in RALS were comparable to those in CLS.
    May 2025, Langenbeck's archives of surgery, 410(1) (1), 165 - 165, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yasufumi Koterazawa, Hironobu Goto, Tatsuya Kaneko, Yuki Azumi, Ryuichiro Sawada, Taro Ikeda, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji
    PURPOSE: Elderly patients with esophageal squamous cell carcinoma (ESCC) have more comorbidities than young patients do. Elderly smokers have a high mortality rate owing to physical dysfunction. This study aimed to identify risk factors for long-term outcomes after minimally invasive esophagectomy (MIE) in elderly patients with ESCC. METHODS: This study included 110 elderly patients (aged ≥ 75 years) with ESCC who underwent MIE at Kobe University Hospital. Multivariate Cox proportional hazards regression analyses were performed to identify risk factors, including the geriatric nutritional risk index (GNRI), Charlson comorbidity index, and elderly smoker status, defined as smoking at the age of 70 years. RESULTS: Multivariate analysis identified that elderly smokers, cT or cN status (≥ cT2 or cN-positive), and GNRI (≤ 92) were independent prognostic factors for overall survival (p = 0.026, 0.019, and 0.038, respectively). For patients with ≥ cT2 or cN-positive ESCC, elderly smokers or patients with GNRI (≤ 92) have significantly worse survival (p = 0.038). Elderly smokers were at risk of death from other diseases five years postoperatively (p = 0.016). CONCLUSIONS: Elderly smokers, cT2 or cN positivity, and low GNRI were risk factors for poor survival. Furthermore, for patients with ≥ cT2 or cN-positive ESCC, these risk factors were associated with poor survival.
    May 2025, Surgery today, 55(5) (5), 659 - 667, English, Domestic magazine
    Scientific journal

  • Yuki Azumi, Naoki Urakawa, Shingo Kanaji, Hiroki Yokoo, Atsushi Shimada, Ryuichiro Sawada, Taro Ikeda, Yasufumi Koterazawa, Tomoaki Aoki, Hitoshi Harada, Yasunori Otowa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    BACKGROUND: Overlap anastomosis is widely used in gastrointestinal reconstruction during minimally invasive gastrectomy. The entry hole of the anastomosis is typically closed with hand-sewn sutures because of concerns about stenosis. This study aimed to compare the efficacy of linear stapler (LS) closure with that of hand-sewn closure of the entry hole in overlap anastomosis. METHODS: We included 172 patients who underwent overlap anastomosis during laparoscopic or robot-assisted total gastrectomy (TG, Roux-en-Y) or distal gastrectomy (DG, Roux-en-Y/Billroth II) between February 2020 and September 2024. The patients were divided into two groups based on the method of entry hole closure: the suturing group (S group) and the LS group. Surgical outcomes were retrospectively analyzed. RESULTS: There were no significant differences in patient characteristics or tumor staging between the two groups. TG was performed in 46 and 17 patients in the S and LS groups, respectively, whereas DG was performed in 41 and 68 patients in the S and LS groups, respectively. In TG patients, there was no significant difference in operative time, but the esophageal-jejunal overlap anastomosis time was significantly shorter in the LS group (38.3 vs. 20.5 min, P < 0.001). The incidence of postoperative complications was similar in both groups, and no cases of stenosis were observed in the LS group. In DG patients, the operative time and gastric-jejunal overlap anastomosis time were significantly shorter in the LS group (294 min vs. 253 min, P = 0.002; 28.5 vs. 9.0 min, P < 0.001). The length of postoperative hospital stay was significantly shorter in the LS group (13 vs. 11 days, P = 0.01). CONCLUSION: Using an LS to close the entry hole in an overlapping anastomosis during minimally invasive gastrectomy can reduce the anastomosis time and may be a safe option without increasing the risk of stenosis.
    May 2025, Surgical endoscopy, 39(5) (5), 3346 - 3353, English, International magazine
    Scientific journal

  • Naoki Urakawa, Shingo Kanaji, Ryuichiro Sawada, Yasufumi Koterazawa, Taro Ikeda, Hitoshi Harada, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    BACKGROUND: Neoadjuvant chemotherapy is widely recognized as the established treatment for advanced gastric cancer. However, predicting its efficacy before surgery remains challenging. AIM: The present study aimed to evaluate the effectiveness of 18F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) as a predictor of treatment response to the S-1+Oxaliplatin regimen (SOX). METHODS AND RESULTS: Thirty patients who underwent gastrectomy following neoadjuvant SOX between January 2021 and July 2023 were included. Patients underwent FDG-PET pre- and postsurgery. The maximum standardized uptake value (SUVmax) from FDG-PET was examined in relation to histological tumor response and prognosis. SUVmax decreased significantly after chemotherapy in all patients (p < 0.001), especially in those with Grade 1a, 2, and 3 tumors (p < 0.05). SUV reduction increased stepwise with the histological response grade. Optimal cut-off values for the percentage decrease in SUVmax (ΔSUVmax) predictive of histologic efficacy were identified as 53% (area under curve 0.855, p = 0.0018) for Grade 1b or higher and 75% (area under curve 0.806, p = 0.0044) for Grade 2 or higher. Patients with ΔSUVmax > 50% had improved recurrence-free survival (p = 0.027). CONCLUSION: FDG-PET may be useful as a predictor of treatment response in neoadjuvant SOX therapy for gastric cancer. The determination of the optimal ΔSUVmax value may enhance the precision of histological tumor response prediction.
    Apr. 2025, Cancer reports (Hoboken, N.J.), 8(4) (4), e70190, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 右上葉区域肺静脈分岐の破格を伴う食道癌に対してロボット支援食道切除術を行った1例
    金子 達也, 後藤 裕信, 小寺澤 康文, 青木 丈明, 金治 新悟, 掛地 吉弘
    Mar. 2025, 手術, 79(3) (3), 367 - 372

  • RIKUYA TORIGOE, TARO OSHIKIRI, HIRONOBU GOTO, YASUHUMI KOTERAZAWA, RYUICHIRO SAWADA, TARO IKEDA, HITOSHI HARADA, NAOKI URAKAWA, HIROSHI HASEGAWA, SHINGO KANAJI, KIMIHIRO YAMASHITA, TAKERU MATSUDA, YOSHIHIRO KAKEJI
    Anticancer Research USA Inc., Dec. 2024, Anticancer Research, 44(12) (12), 5485 - 5493
    Scientific journal

  • Hiroki Yokoo, Shingo Kanaji, Taro Ikeda, Yasufumi Koterazawa, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    Elsevier BV, Dec. 2024, Journal of Gastrointestinal Surgery, 101934 - 101934
    Scientific journal

  • Hiroshi Saiga, Taro Oshikiri, Hironobu Goto, Yasufumi Koterazawa, Takashi Kato, Yukari Adachi, Toshitatsu Takao, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Yuzo Kodama, Yoshihiro Kakeji
    Elsevier BV, Dec. 2024, Journal of Gastrointestinal Surgery, 28(12) (12), 2001 - 2007
    Scientific journal

  • Yasufumi Koterazawa, Hironobu Goto, Hiroshi Saiga, Yuki Azumi, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji
    Abstract Background Esophagectomy with lymphadenectomy is the primary treatment for esophageal squamous cell carcinoma (ESCC). However, intensive dissection of lymph nodes (LNs) along the recurrent laryngeal nerve (RLN) is associated with RLN palsy and pulmonary complications leading to poor survival. Therefore, this study aimed identify the risk factors for LNs metastasis along the RLN in patients with ESCC. Methods The present study included 168 patients with lower thoracic esophageal and esophagogastric junction (EGJ) squamous cell carcinoma who underwent esophagectomy with total mediastinal lymphadenectomy at Kobe University Hospital. Left/Right cervical paraesophageal (101 L/R), left/right recurrent nerve (106 recL/R), and left tracheobronchial LNs (106 tbL) were defined as LNs along the RLN. We evaluated the pathological distance between the proximal tumor boundary and the EGJ using images of the fixed specimen (PB‐EGJ length). Results LN metastasis along the RLN was observed in 19 (11%) patients. The percentage of patients with a longer PB‐EGJ length and cLNs metastasis was higher in the LNs metastasis along the RLN positive‐group than in the RLN‐negative group (p = 0.0075 and p = 0.013, respectively). The incidence of LNs metastasis along the RLN was 0% (95% confidence interval [CI] = 0–7.7%) when the PB‐EGJ length was <4 cm. Univariate analysis showed that patients with cLNs metastasis negative had a low risk for LNs metastasis along the RLN (odds ratio = 0.26 and 95% CI = 0.083–0.82). Conclusions Patients with a PB‐EGJ length <4 cm and negative for cLNs metastasis may be candidates for the omission of lymphadenectomy along the RLN.
    Lead, Wiley, Nov. 2024, World Journal of Surgery
    Scientific journal

  • Takeru Matsuda, Kimihiro Yamashita, Hiroshi Hasegawa, Ryuichiro Sawada, Yasufumi Koterazawa, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Shingo Kanaji, Yoshihiro Kakeji
    Springer Science and Business Media LLC, Sep. 2024, Surgery Today
    Scientific journal

  • Hironobu Goto, Taro Oshikiri, Yasufumi Koterazawa, Ryuichiro Sawada, Taro Ikeda, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    Springer Science and Business Media LLC, Sep. 2024, Esophagus, 22(1) (1), 59 - 67
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takao Tsuneki, Takeru Matsuda, Ryuichiro Sawada, Hiroshi Hasegawa, Kimihiro Yamashita, Yasufumi Koterazawa, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Shingo Kanaji, Yoshihiro Kakeji
    Springer Science and Business Media LLC, Jun. 2024, Surgery Today
    Scientific journal

  • Shingo Kanaji, Naoki Urakawa, Hitoshi Harada, Atsushi Shimada, Yasufumi Koterazawa, Ryuichiro Sawada, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji
    Springer Science and Business Media LLC, Jun. 2024, Langenbeck's Archives of Surgery, 409(1) (1)
    Scientific journal

  • Yasufumi Koterazawa, Hironobu Goto, Hiroshi Saiga, Takashi Kato, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji
    Springer Science and Business Media LLC, May 2024, Surgical Endoscopy, 38(7) (7), 3625 - 3635
    Scientific journal

  • 小寺澤 康文, 後藤 裕信, 掛地 吉弘
    (株)日本臨床社, May 2024, 日本臨床, 82(増刊3 食道癌2024) (増刊3 食道癌2024), 532 - 536, Japanese

  • Hironobu Goto, Taro Oshikiri, Takashi Kato, Yoshiaki Nagatani, Yohei Funakoshi, Yasufumi Koterazawa, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Hironobu Minami, Yoshihiro Kakeji
    Background In Japan, preoperative adjuvant chemotherapy followed by surgical resection is the standard treatment for patients with locally advanced esophageal squamous cell carcinoma. However, the risk of recurrence after surgical resection remains high. Although a randomized controlled trial evaluating the efficacy of nivolumab, a fully human monoclonal anti-programmed death 1 antibody, as postoperative adjuvant therapy after neoadjuvant chemoradiotherapy and surgery established its superior efficacy as adjuvant therapy, the efficacy for patients who received preoperative adjuvant chemotherapy has not been demonstrated. This study aims to elucidate the efficacy and safety of nivolumab as postoperative adjuvant therapy for patients with esophageal squamous cell carcinoma after preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. Methods This study is a multi-institutional, single-arm, Phase II trial. We plan to recruit 130 esophageal squamous cell carcinoma patients, who have undergone preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. If the patient did not have a pathological complete response, nivolumab is started as a postoperative adjuvant therapy within 4–16 weeks after surgery. The nivolumab dose is 480 mg/day every four weeks. Nivolumab is administered for up to 12 months. The primary endpoint is disease-free survival; the secondary endpoints are overall survival, distant metastasis-free survival, and incidence of adverse events. Discussion To our knowledge this study is the first trial establishing the efficacy of nivolumab as postoperative adjuvant therapy for patients with esophageal squamous cell carcinoma after preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. In Japan, preoperative adjuvant chemotherapy followed by surgery is a well-established standard treatment for resectable, locally advanced esophageal squamous cell carcinoma. Therefore, developing an effective postoperative adjuvant therapy has been essential for improving oncological outcomes.
    Public Library of Science (PLoS), Apr. 2024, PLOS ONE, 19(4) (4), e0299742 - e0299742
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yasufumi Koterazawa, Taro Oshikiri, Hironobu Goto, Takashi Kato, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    Lead, Springer Science and Business Media LLC, Feb. 2024, Annals of Surgical Oncology, 31(6) (6), 4018 - 4018
    Scientific journal

  • 後藤 裕信, 小寺澤 康文, 加藤 喬, 押切 太郎, 掛地 吉弘
    (株)日本臨床社, Jan. 2024, 日本臨床, 82(増刊1 ロボット支援手術) (増刊1 ロボット支援手術), 163 - 169, Japanese

  • Yasufumi Koterazawa, Taro Oshikiri, Hironobu Goto, Takashi Kato, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    Lead, Springer Science and Business Media LLC, Dec. 2023, Annals of Surgical Oncology, 31(4) (4), 2482 - 2489
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takashi Kato, Taro Oshikiri, Yasufumi Koterazawa, Hironobu Goto, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    Springer Science and Business Media LLC, Dec. 2023, Surgery Today
    Scientific journal

  • Yasufumi Koterazawa, Manabu Ohashi, Masaru Hayami, Rie Makuuchi, Satoshi Ida, Koshi Kumagai, Takeshi Sano, Souya Nunobe
    Lead, Springer Science and Business Media LLC, May 2023, Gastric Cancer, 26(5) (5), 823 - 832
    Scientific journal

  • Yasufumi Koterazawa, Manabu Ohashi, Masaru Hayami, Rie Makuuchi, Satoshi Ida, Koshi Kumagai, Takeshi Sano, Souya Nunobe
    Lead, Springer Science and Business Media LLC, Feb. 2023, Gastric Cancer, 26(3) (3), 451 - 459
    Scientific journal

  • Yasufumi Koterazawa, Manabu Ohashi, Masaru Hayami, Rie Makuuchi, Satoshi Ida, Koshi Kumagai, Takeshi Sano, Souya Nunobe
    Lead, Springer Science and Business Media LLC, May 2022, Gastric Cancer, 25(5) (5), 973 - 981
    Scientific journal

  • Yasufumi Koterazawa, Manabu Ohashi, Satoshi Hayami, Koshi Kumagai, Takeshi Sano, Souya Nunobe
    Objective: To identify the minimum length of esophageal resection to ensure a pathologically negative proximal margin (PM) in total gastrectomy for gastric cancer. Background: In total gastrectomy, a certain esophageal length is resected to obtain a pathologically negative PM because of the possibility of unexpected pathological esophageal invasion. However, a recommendation regarding the esophageal transection site in total gastrectomy has not been established. Methods: The data of patients who underwent total gastrectomy for gastric cancer from 2005 to 2018 were collected. We evaluated the length of unexpected pathological esophageal invasion (esophageal ΔPM) in each type of disease and each location of the gross proximal tumor boundary (PB) using the length between the PB and the esophagogastric junction (PB-EGJ length). Results: Of the 1005 patients eligible for this study, 277, 196, and 532 had cT1, cT2–4 expansive (Exp), and cT2–4 infiltrative (Inf) growth patterns, respectively. In cT1 and Exp, no unexpected pathological esophageal invasion occurred when the PB-EGJ length was >1 cm, whereas pathological esophageal invasion occurred in 20.0% of cT1 and 32.7% of Exp when the PB-EGJ length was ≤1 cm. The esophageal ΔPM was <1 cm. In Inf, no unexpected pathological esophageal invasion occurred when the PB-EGJ length was >3 cm, whereas pathological esophageal invasion occurred in 17.4% of patients when the PB-EGJ length was ≤3 cm. The esophageal ΔPM was <2 cm. Conclusions: New recommendations regarding the esophageal resection length required to ensure a pathologically negative PM in total gastrectomy are herein proposed.
    Lead, Ovid Technologies (Wolters Kluwer Health), Jan. 2022, Annals of Surgery Open, 3(1) (1), e127 - e127
    Scientific journal

  • Yasufumi Koterazawa, Taro Oshikiri, Gosuke Takiguchi, Naoki Urakawa, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Tetsu Nakamura, Satoshi Suzuki, Yoshihiro Kakeji
    Abstract Background Patients often experience severe weight loss after oesophagectomy. Enteral nutrition via a feeding jejunostomy tube (FT) is commonly practised. This study aimed to assess the effect of severe weight loss postoperatively and enteral nutrition via an FT on long-term prognosis after oesophagectomy. Methods This study analysed 317 patients who underwent minimally invasive oesophagectomy at Kobe University Hospital and Hyogo Cancer Center from 2010 to 2015. The patients’ body weight was evaluated at 3 months postoperatively. They were organised into the severe weight loss (n = 65) and moderate weight loss (n = 252) groups. Furthermore, they were categorised into the FT group (184 patients who had an FT placed during oesophagectomy) and no-FT group (133 patients without FT). Patients (119 per group) matched for the FT and no-FT groups were identified via propensity score matching. Results The 5-year overall survival (OS) rate in the severe weight loss group was significantly lower (p = 0.024). In the multivariate analysis, tumour invasion depth (pT3-4), preoperative therapy and severe weight loss had a worse OS (hazard ratio = 1.89; 95% confidence interval = 1.12–3.17, hazard ratio = 2.11; 95% confidence interval = 1.25–3.54, hazard ratio = 1.82; 95% confidence interval = 1.02–3.524, respectively). No significant differences in the number of severe weight loss patients and OS were found between the FT and no-FT groups. Conclusion Severe weight loss is significantly associated with poor OS. In addition, enteral nutrition via an FT did not improve the severe weight loss and OS.
    Lead, Springer Science and Business Media LLC, Dec. 2020, BMC Gastroenterology, 20(1) (1)
    Scientific journal

  • Shuichi Fujiwara, Teruya Kawamoto, Yohei Kawakami, Yasufumi Koterazawa, Hitomi Hara, Toshiyuki Takemori, Kazumichi Kitayama, Shunsuke Yahiro, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Michiyo Koyanagi-Aoi, Takashi Aoi, Ryosuke Kuroda, Toshihiro Akisue
    Abstract Background Cancer stem cells (CSCs) are considered to be responsible for tumor initiation, formation, and poor prognosis of cancer patients. However, the rarity of CSCs in clinical samples makes it difficult to elucidate characteristics of CSCs, especially in osteosarcoma (OS). The aim of this study is to verify whether it is possible to generate CSC-like cells by transducing defined factors into an OS cell line. Methods We retrovirally transduced the Octamer-binding transcription factor 3/4 (OCT3/4), Kruppel-like factor 4 (KLF4), and SRY-box transcription factor 2 (SOX2) genes into the MG-63 human OS cell line (MG-OKS). Parental and GFP-transduced MG-63 cells were used as negative control. We assessed the properties of the generated cells in vitro and in vivo. Multiple comparisons among groups were made using a one-way analysis of variance (ANOVA) followed by post hoc testing with Tukey’s procedure. Results MG-OKS cells in vitro exhibited the significantly increased mRNA expression levels of CSC markers (CD24,CD26, andCD133), decreased cell growth, increased chemoresistance and cell migration, and enhanced sphere formation. Notably, MG-OKS cells cultured under osteogenic differentiation conditions showed strongly positive staining for both Alizarin Red S and alkaline phosphatase, indicating osteogenesis of the cells. Gene ontology analysis of microarray data revealed significant upregulation of epidermal-related genes. Tumors derived from MG-OKS cells in vivo were significantly larger than those from other cells in μCT analysis, and immunohistochemical staining showed that Ki-67, osteocalcin, and HIF-1α-positive cells were more frequently detected in the MG-OKS-derived tumors. Conclusions In this study, we successfully generated OS CSC-like cells with significantly enhanced CSC properties following transduction of defined factors.
    Springer Science and Business Media LLC, Oct. 2020, Stem Cell Research & Therapy, 11(1) (1)
    Scientific journal

  • Yasufumi Koterazawa, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Yoshihiro Kakeji, Takashi Aoi
    In the original publication of the article, the following errors were noted and corrected in this correction.
    Oct. 2020, Journal of gastroenterology, 55(10) (10), 1010 - 1011, English, Domestic magazine

  • Kazumasa Horie, Taro Oshikiri, Yu Kitamura, Masaki Shimizu, Yuta Yamazaki, Hiroki Sakamoto, Sonoko Ishida, Yasufumi Koterazawa, Taro Ikeda, Masashi Yamamoto, Shingo Kanaji, Yoshiko Matsuda, Kimihiro Yamashita, Takeru Matsuda, Tetsu Nakamura, Satoshi Suzuki, Yoshihiro Kakeji
    INTRODUCTION: Recent advances in the treatment for esophageal cancer have improved the prognosis after esophagectomy, but they have led to an increased incidence of gastric tube cancer. In most patients who underwent retrosternal reconstruction, median sternotomy is performed; it is associated with a risk of postoperative bleeding and osteomyelitis, and pain often negatively affects respiration. Here, we report the first case of thoracoscopic retrosternal gastric conduit resection in the supine position (TRGR-S). MATERIALS AND SURGICAL TECHNIQUE: A 75-year-old male patient was placed in the supine position. Four ports were placed in the left chest wall. The gastric tube was separated from the epicardium, sternum, and left brachiocephalic vein. Because of adhesions between the gastric tube and the right pleura, combined resection of the right pleura was performed. The dorsal side of the gastric tube was dissected before the ventral side, enabling the gastric tube to be suspended from the back of the sternum and, thus, making it easier to expose the surgical field. Next, pedicled jejunal reconstruction via the presternal route was performed. There were no postoperative complications. The pathological diagnosis was signet ring cell carcinoma (pT1b, pN0, M0, pStage I), indicating R0 resection. DISCUSSION: TRGR-S does not require sternotomy, reducing the risk of postoperative bleeding and osteomyelitis. In the presence of adhesions, TRGR-S is safe and provides a good surgical view. It is also reliable procedure for resection of retrosternal gastric tube cancer, and it is ergonomic for surgeons.
    Jul. 2020, Asian journal of endoscopic surgery, 13(3) (3), 461 - 464, English, Domestic magazine
    Scientific journal

  • Yasufumi Koterazawa, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Yoshihiro Kakeji, Takashi Aoi
    Abstract Background The esophagus is known to be derived from the foregut. However, the mechanisms regulating this process remain unclear. In particular, the details of the human esophagus itself have been poorly researched. In this decade, studies using human induced pluripotent stem cells (hiPSCs) have proven powerful tools for clarifying the developmental biology of various human organs. Several studies using hiPSCs have demonstrated that retinoic acid (RA) signaling promotes the differentiation of foregut into tissues such as lung and pancreas. However, the effect of RA signaling on the differentiation of foregut into esophagus remains unclear. Methods We established a novel stepwise protocol with transwell culture and an air–liquid interface system for esophageal epithelial cell (EEC) differentiation from hiPSCs. We then evaluated the effect of all-trans retinoic acid (ATRA), which is a retinoic acid receptor (RAR)α, RARβ and RARγ agonist, on the differentiation from the hiPSC-derived foregut. Finally, to identify which RAR subtype was involved in the differentiation, we used synthetic agonists and antagonists of RARα and RARγ, which are known to be expressed in esophagus. Results We successfully generated stratified layers of cells expressing EEC marker genes that were positive for lugol staining. The enhancing effect of ATRA on EEC differentiation was clearly demonstrated with quantitative reverse transcription polymerase chain reaction, immunohistology, lugol-staining and RNA sequencing analyses. RARγ agonist and antagonist enhanced and suppressed EEC differentiation, respectively. RARα agonist had no effect on the differentiation. Conclusion We revealed that RARγ activation promotes the differentiation of hiPSCs-derived foregut into EECs.
    Lead, Springer Science and Business Media LLC, Jun. 2020, Journal of Gastroenterology, 55(8) (8), 763 - 774
    Scientific journal

  • Yasufumi Koterazawa, Taro Oshikiri, Gosuke Takiguchi, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Tetsu Nakamura, Yasuhiro Fujino, Masahiro Tominaga, Satoshi Suzuki, Yoshihiro Kakeji
    Lead, Springer Science and Business Media LLC, Jun. 2019, Annals of Surgical Oncology, 26(9) (9), 2899 - 2904
    Scientific journal

  • Yasufumi Koterazawa, Taro Oshikiri, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Tetsu Nakamura, Satoshi Suzuki, Yoshihiro Kakeji
    Lead, Oxford University Press (OUP), Apr. 2019, Diseases of the Esophagus
    Scientific journal

  • 【機能性消化管疾患診療の実際】嚥下障害・つまり感があれば器質性疾患に注意
    小寺澤 康文, 中村 哲, 掛地 吉弘
    Lead, (公社)日本医師会, Jan. 2019, 日本医師会雑誌, 147(10) (10), 1996 - 1996, Japanese

  • 第5回 食道がんに用いられる抗がん剤（消化器外科おくすりメモ）
    小寺澤 康文
    Lead, May 2018, 消化器外科NURSING, 23(5) (5), 64 - 65, Japanese

  • 第4回 食道がんに用いられる抗がん剤（消化器外科おくすりメモ）
    小寺澤 康文
    Lead, Apr. 2018, 消化器外科NURSING, 23(4) (4), 68 - 69, Japanese

  • Yasufumi Koterazawa, Tetsu Nakamura, Taro Oshikiri, Shingo Kanaji, Shinwa Tanaka, Tsukasa Ishida, Kimihiro Yamashita, Takeru Matsuda, Yoshinori Morita, Satoshi Suzuki, Yoshihiro Kakeji
    Lead, Springer Science and Business Media LLC, Mar. 2018, Surgery Today, 48(8) (8), 783 - 789
    Scientific journal

  • Yasufumi KOTERAZAWA, Shoichi KINUGASA, Hiroyuki MONMA, Hiroshige HORI, Shinji KISHI, Takeshi NAKAMURA
    Lead, Japan Surgical Association, 2017, Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 78(3) (3), 536 - 541
    Scientific journal

  • 吉田 真也, 石井 隆道, 小寺澤 康文, 松浦 正徒, 長井 和之, 姜 貴嗣, 伊丹 淳, 橋本 公夫, 京極 高久
    (一社)日本消化器外科学会, Aug. 2016, 日本消化器外科学会雑誌, 49(8) (8), 707 - 713, Japanese

  • 吉田 真也, 石原 美佐, 宇山 直樹, 小寺澤 康文, 住井 敦彦, 安川 大貴, 松浦 正徒, 伊丹 淳, 橋本 公夫, 京極 高久
    (一社)日本消化器外科学会, Jan. 2016, 日本消化器外科学会雑誌, 49(1) (1), 29 - 35, Japanese

  • 胆嚢捻転症の６手術例
    小寺澤 康文
    Lead, 2016, 腹部救急医学会雑誌, 36(4) (4), 813 - 817

  • 門脈腫瘍栓を伴う転移性肝癌に対して腹腔鏡下肝部分切除術を施行した左側胆嚢の1症例
    石井 隆道, 吉田 真也, 小寺澤 康文, 松浦 正徒, 長井 和之, 姜 貴嗣, 伊丹 淳, 京極 高久
    (一社)日本内視鏡外科学会, Dec. 2015, 日本内視鏡外科学会雑誌, 20(7) (7), OS278 - 3, Japanese

  • 当科における大腸癌の穿孔例の検討
    小寺澤 康文, 牧野 健太, 堀江 和正, 吉田 真也, 松浦 正徒, 長井 和之, 石井 隆道, 姜 貴嗣, 伊丹 淳, 京極 高久
    日本臨床外科学会, Oct. 2015, 日本臨床外科学会雑誌, 76(増刊) (増刊), 711 - 711, Japanese

  • 胃癌術後の異時性孤立性脾転移とS状結腸癌に対して腹腔鏡下に脾摘術とS状結腸切除術を施行した1例
    姜 貴嗣, 吉田 真也, 牧野 健太, 堀江 和正, 小寺澤 康文, 長井 和之, 松浦 正徒, 石井 隆道, 伊丹 淳, 京極 高久
    日本臨床外科学会, Oct. 2015, 日本臨床外科学会雑誌, 76(増刊) (増刊), 829 - 829, Japanese

  • Rhabdoid featureを呈した巨大横行結腸癌の1例
    松浦 正徒, 堀江 和正, 牧野 健太, 吉田 真也, 小寺澤 康文, 長井 和之, 石井 隆道, 姜 貴嗣, 伊丹 淳, 京極 高久
    日本臨床外科学会, Oct. 2015, 日本臨床外科学会雑誌, 76(増刊) (増刊), 852 - 852, Japanese

  • 腹腔鏡下胃管再建術は術後の横隔膜ヘルニアを助長するか
    伊丹 淳, 松浦 正徒, 小寺澤 康文, 吉田 真也, 住井 敦彦, 安川 大貴, 長井 和之, 石井 隆道, 姜 貴嗣, 京極 高久
    (NPO)日本食道学会, Jul. 2015, 日本食道学会学術集会プログラム・抄録集, 69回, 100 - 100, Japanese

  • 上部消化管 用手補助(HALS)を用いない腹腔鏡補助下胃管作成術の検討
    伊丹 淳, 吉田 真也, 小寺澤 康文, 安川 大貴, 住井 敦彦, 松浦 正徒, 長井 和之, 石井 隆道, 姜 貴嗣, 京極 高久
    (一社)日本外科学会, Apr. 2015, 日本外科学会定期学術集会抄録集, 115回, OP - 2, Japanese

  • 小寺澤 康文, 石井 隆道, 吉田 真也, 住井 敦彦, 安川 大貴, 京極 高久
    Lead, 日本臨床外科学会, Dec. 2014, 日本臨床外科学会雑誌, 75(12) (12), 3369 - 3374, Japanese

  • 嚢胞内腫瘍を呈した両側乳腺葉状腫瘍の1例
    吉田 真也, 奥野 敏孝, 小寺澤 康文, 住井 敦彦, 安川 大貴, 松浦 正徒, 長井 和之, 石井 隆道, 姜 貴嗣, 伊丹 淳, 京極 高久
    日本臨床外科学会, Oct. 2014, 日本臨床外科学会雑誌, 75(増刊) (増刊), 613 - 613, Japanese

  • 潰瘍性大腸炎穿孔後に人工肛門周囲に発症した壊疽性膿皮症の治療に難渋した1例
    松浦 正徒, 吉田 真也, 小寺澤 康文, 住井 敦彦, 安川 大貴, 長井 和之, 石井 隆道, 姜 貴嗣, 伊丹 淳, 京極 高久
    日本臨床外科学会, Oct. 2014, 日本臨床外科学会雑誌, 75(増刊) (増刊), 749 - 749, Japanese

  • S状結腸癌に対する腹腔鏡下S状結腸切除術(SRA温存D2廓清)
    安川 大貴, 小寺澤 康文, 吉田 真也, 住井 敦彦, 松浦 正徒, 長井 和之, 石井 隆道, 姜 貴嗣, 伊丹 淳, 京極 高久
    (一社)日本内視鏡外科学会, Oct. 2014, 日本内視鏡外科学会雑誌, 19(7) (7), 447 - 447, Japanese

  • 後期研修医による腹腔鏡下結腸右半切除術
    住井 敦彦, 小寺澤 康文, 吉田 真也, 安川 大貴, 松浦 正徒, 長井 和之, 石井 隆道, 姜 貴嗣, 伊丹 淳, 京極 高久
    (一社)日本内視鏡外科学会, Oct. 2014, 日本内視鏡外科学会雑誌, 19(7) (7), 448 - 448, Japanese

  • 腹腔鏡下幽門側胃切除術術前にダイナミックCT検査が有用であった腸回転異常症の1例
    松浦 正徒, 吉田 真也, 小寺澤 康文, 住井 敦彦, 安川 大貴, 長井 和之, 石井 隆道, 姜 貴嗣, 伊丹 淳, 京極 高久
    (一社)日本内視鏡外科学会, Oct. 2014, 日本内視鏡外科学会雑誌, 19(7) (7), 825 - 825, Japanese

  • 当科における腹腔鏡下胃全摘術の再建法の変遷と工夫点に関する検討
    伊丹 淳, 姜 貴嗣, 松浦 正徒, 小寺澤 康文, 吉田 真也, 住井 敦彦, 安川 大貴, 長井 和之, 石井 隆道, 京極 高久
    (一社)日本消化器外科学会, Jul. 2014, 日本消化器外科学会総会, 69回, RV - 5, Japanese

  • 長井 和之, 小寺澤 康文, 吉田 真也, 住井 敦彦, 安川 大貴, 松浦 正徒, 石井 隆道, 姜 貴嗣, 伊丹 淳, 京極 高久
    (一社)日本膵臓学会, Jun. 2014, 膵臓, 29(3) (3), 650 - 650, Japanese

  • 石井 隆道, 小寺澤 康文, 吉田 真也, 住井 敦彦, 安川 大貴, 松浦 正徒, 長井 和之, 姜 貴嗣, 伊丹 淳, 京極 高久
    (一社)日本外科学会, Mar. 2014, 日本外科学会雑誌, 115(臨増2) (臨増2), 586 - 586, Japanese

  • 伊丹 淳, 小寺澤 康文, 吉田 真也, 住井 敦彦, 安川 大貴, 松浦 正徒, 長井 和之, 石井 隆道, 姜 貴嗣, 京極 高久
    (一社)日本外科学会, Mar. 2014, 日本外科学会雑誌, 115(臨増2) (臨増2), 828 - 828, Japanese

  • 当科における腹腔鏡下肝切除術の導入の現状
    姜 貴嗣, 石井 隆道, 長井 和之, 小寺澤 康文, 吉田 真也, 安川 大貴, 住井 敦彦, 松浦 正徒, 伊丹 淳, 京極 高久
    (一社)日本内視鏡外科学会, Nov. 2013, 日本内視鏡外科学会雑誌, 18(7) (7), 559 - 559, Japanese

  • 当科における腹腔鏡下胃全摘術の現状
    伊丹 淳, 松浦 正徒, 姜 貴嗣, 小寺澤 康文, 吉田 真也, 住井 敦彦, 安川 大貴, 長井 和之, 石井 隆道, 京極 高久
    (一社)日本内視鏡外科学会, Nov. 2013, 日本内視鏡外科学会雑誌, 18(7) (7), 581 - 581, Japanese

  • 腹腔鏡下左側大腸癌手術における内側アプローチの工夫
    安川 大貴, 小寺澤 康文, 吉田 真也, 住井 敦彦, 松浦 正徒, 長井 和之, 石井 隆道, 姜 貴嗣, 伊丹 淳, 京極 高久
    (一社)日本内視鏡外科学会, Nov. 2013, 日本内視鏡外科学会雑誌, 18(7) (7), 649 - 649, Japanese

  • 腹腔鏡下直腸低位前方切除術で経肛門ドレーン留置後に憩室穿孔を発症した1例
    松浦 正徒, 吉田 真也, 小寺澤 康文, 住井 敦彦, 安川 大貴, 長井 和之, 石井 隆道, 姜 貴嗣, 伊丹 淳, 京極 高久
    日本臨床外科学会, Oct. 2013, 日本臨床外科学会雑誌, 74(増刊) (増刊), 591 - 591, Japanese

  • 食道癌、大腸癌の重複癌に遠隔(肝・肺)転移を認め、完全切除を施行した一例
    安川 大貴, 小寺澤 康文, 吉田 真也, 住井 敦彦, 松浦 正徒, 長井 和之, 石井 隆道, 姜 貴嗣, 伊丹 淳, 京極 高久
    日本臨床外科学会, Oct. 2013, 日本臨床外科学会雑誌, 74(増刊) (増刊), 839 - 839, Japanese

  • 術前に前区域領域を支配する右副肝管が疑われた胆石症に対して腹腔鏡下胆嚢摘出術を施行した一例
    前川 嵩太, 宇山 直樹, 小寺澤 康文, 吉田 真也, 住井 敦彦, 安川 大貴, 松浦 正徒, 石井 隆道, 姜 貴嗣, 伊丹 淳, 京極 高久
    日本臨床外科学会, Oct. 2013, 日本臨床外科学会雑誌, 74(増刊) (増刊), 1028 - 1028, Japanese

■ MISC
  • 藤原周一, Kawamoto Teruya, 青井貴之, 小寺澤康文, Hara Hitomi, 深瀬直政, 蒲田悦子, 竹森俊幸, 秋末敏宏, 黒田良祐
    (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8号) (8号), S1812 - S1812, Japanese
    [Refereed]

■ Lectures, oral presentations, etc.
  • 十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同手術における結腸間膜尾側からのアプローチの有用性の検討
    島田 淳司、原田 仁、金治 新悟、澤田 隆一郎、小寺澤 康文、裏川 直樹、後藤 裕信、長谷川 寛、山下 公大、松田 武、掛地 吉弘
    第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference
    Public symposium

  • 高齢の胃癌患者に対する術前化学療法の安全性についての検討
    向山 知佑、金治 新悟、小寺澤 康文、澤田 隆一郎、原田 仁、裏川 直樹、長谷川 寛、山下 公大、松田 武、掛地 吉弘
    第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference
    Oral presentation

  • 切除困難な胃GISTに対する術前イマチニブによる補助療法の有用性に関する検討
    安積 佑樹、裏川 直樹、原田 仁、金治 新悟、澤田 隆一郎、小寺澤 康文、後藤 裕信、長谷川 寛、山下 公大、松田 武、掛地 吉弘
    第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference
    Public symposium

  • The significance of conversion surgery following chemotherapy for clinical stage IV gastric cancer
    Harada H, Kanaji S, Sawada R, Koterazawa Y, Urakawa N, Goto H, Hasegawa H, Yamashita K, Matsuda T, Kakeji Y
    第96回日本胃癌学会総会, English, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference
    Oral presentation

  • 当院における進行胃癌に対するロボット支援下胃切除術の工夫
    裏川 直樹、金治 新悟、原田 仁、澤田 隆一郎、小寺澤 康文、後藤 裕信、長谷川 寛、山下 公大、松田 武、掛地 吉弘
    第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference
    Oral presentation

  • 食道胃接合部腺癌に対する腹腔鏡下経裂孔的再建における左横隔膜開放法の有用性
    金治 新悟、裏川 直樹、原田 仁、澤田 隆一郎、小寺澤 康文、後藤 裕信、長谷川 寛、山下 公大、松田 武、掛地 吉弘
    第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference
    Public symposium

  • 術前化学療法を施行した食道癌における腫瘍マーカーと生存転帰の検討
    鳥越 陸矢、後藤 裕信、加藤 喬、小寺澤 康文、澤田 隆一郎、原田 仁、裏川 直樹、長谷川 寛、金治 新悟、山下 公大、松田 武、掛地 吉弘
    第56回制癌剤適応研究会, Japanese, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, Japan, Domestic conference
    Oral presentation

  • 切除不能進行胃癌に対する conversion surgery の周術期化学療法の重要性及び治療成績
    横尾 拓樹、原田 仁、小寺澤 康文、裏川 直樹、後藤 裕信、長谷川 寛、金治 新悟、山下 公大、松田 武、掛地 吉弘
    第56回制癌剤適応研究会, Japanese, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, Japan, Domestic conference
    Public symposium

  • 鼠径リンパ節転移を伴う直腸・肛門管腺癌の術後成績；術前治療と選択的鼠径リンパ節郭清・直腸間膜全切除による治療戦略
    堀川 学、長谷川 寛、加藤 喬、澤田 隆一郎、小寺澤 康文、原田 仁、裏川 直樹、後藤 裕信、金治 新悟、山下 公大、松田 武、掛地 吉弘
    第56回制癌剤適応研究会, Japanese, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, Japan, Domestic conference
    Oral presentation

  • Clinical Significance of SUVmax on FDG-PET in Patients with Rectal Cancer Undergoing NACRT
    Tsuneki T, Matsuda T, Sawada R, Hasegawa H, Yamashita K, Koterazawa Y, Harada H, Urakawa N, Goto H, Kanaji S, Kakeji Y,
    The 19th Annual Academic Surgical Congress, English, Annual Academic Surgical Congress, Washington, D.C., United States, International conference
    Oral presentation

  • 高齢の胃癌患者に対する術前化学療法の安全性についての検討
    向山 知佑、金治 新悟、原田 仁、裏川 直樹、小寺澤 康文、澤田 隆一郎、後藤 裕信、長谷川 寛、山下 公大、松田 武、掛地 吉弘
    第207回近畿外科学会, Japanese, 関西医科大学 外科学講座, 枚方市, Japan, Domestic conference
    Oral presentation

  • リンパ節郭清個数からみる MIE における上縦隔リンパ節郭清の重要性
    小寺澤 康文、後藤 裕信、澤田 隆一郎、原田 仁、裏川 直樹、長谷川 寛、金治 新悟、山下 公大、松田 武、掛地 吉弘
    第207回近畿外科学会, Japanese, 関西医科大学 外科学講座, 枚方市, Japan, Domestic conference
    Oral presentation

  • 当院におけるTaTME併用大腸全摘術の手術成績
    澤田 隆一郎、松田 武、山下 公大、長谷川 寛、小寺澤 康文、原田 仁、裏川 直樹、後藤 裕信、金治 新悟、掛地 吉弘
    日本消化器病学会近畿支部第120回例会, Japanese, 神戸大学大学院医学研究科外科学講座 肝胆膵外科学分野, 神戸, Japan, Domestic conference
    Public symposium

  • 十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同手術における結腸間膜尾側からの腹腔鏡アプローチの有用性の検討
    島田 淳司、金治 新悟、澤田 隆一郎、小寺澤 康文、原田 仁、裏川 直樹、後藤 裕信、長谷川 寛、山下 公大、松田 武、掛地 吉弘
    第194回兵庫県外科医会学術集会, Japanese, 兵庫県外科医会, 神戸, Japan, Domestic conference
    Oral presentation

  • 深層学習アルゴリズムに基づくイメージングサイトメトリーを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索
    安達 祐里、山下 公大、長坂 暢、阿部 智喜、向山 知佑、常城 宇生、安藤 正恭、加藤 喬、小寺澤 康文、澤田 隆一郎、原田 仁、裏川 直樹、後藤 裕信、長谷川 寛、金治 新悟、松田 武、掛地 吉弘
    第36回日本バイオセラピィ学会学術集会総会, Japanese, 昭和大学医学部内科学講座腫瘍内科学部門, 東京, Japan, Domestic conference
    Oral presentation

  • 安全な Collard 変法吻合を目指した変革と短期成績
    加藤 喬、押切 太郎、小寺澤 康文、後藤 裕信、澤田 隆一郎、原田 仁、裏川 直樹、長谷川 寛、金治 新悟、山下 公大、松田 武、掛地 吉弘
    第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference
    Oral presentation

  • 下部進行直腸癌に対する TaTME 併用の有用性とラーニングカーブに関する検討
    澤田 隆一郎、松田 武、山下 公大、長谷川 寛、小寺澤 康文、原田 仁、裏川 直樹、後藤 裕信、金治 新悟、押切 太郎、掛地 吉弘
    第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference
    Oral presentation

  • ロボット支援食道切除における上縦隔リンパ節郭清手技と短期成績
    小寺澤 康文、押切 太郎、加藤 喬、澤田 隆一郎、原田 仁、裏川 直樹、後藤 裕信、長谷川 寛、金治 新悟、山下 公大、松田 武、掛地 吉弘
    第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference
    Oral presentation

  • ロボット支援胃切除術におけるリンパ節郭清時間の learning curve
    裏川 直樹、金治 新悟、小寺澤 康文、澤田 隆一郎、原田 仁、後藤 裕信、長谷川 寛、山下 公大、松田 武、押切 太郎、掛地 吉弘
    第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference
    Oral presentation

  • 多発リンパ節転移を伴う進行食道癌に対する Minimally invasive esophagectomy
    後藤 裕信、押切 太郎、加藤 喬、小寺澤 康文、澤田 隆一郎、原田 仁、裏川 直樹、長谷川 寛、金治 新悟、山下 公大、松田 武、掛地 吉弘
    第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference
    Oral presentation

  • 経肛門アプローチ併用による２チーム側方郭清の手術手技と手術成績
    松田 武、澤田 隆一郎、長谷川 寛、山下 公大、加藤 喬、小寺澤 康文、原田 仁、後藤 裕信、裏川 直樹、金治 新悟、押切 太郎、掛地 吉弘
    第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference
    Public symposium

  • 人間工学に基づく「鏡視下クロソイド・カーブ針」の開発
    松田 武、山下 公大、長谷川 寛、澤田 隆一郎、後藤 裕信、裏川 直樹、原田 仁、小寺澤 康文、金治 新悟、押切 太郎、掛地 吉弘
    第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference
    Oral presentation

  • 当院における腹腔鏡下スリーブ状胃切除術の短期治療成績の検討
    裏川 直樹、金治 新悟、原田 仁、澤田 隆一郎、小寺澤 康文、後藤 裕信、長谷川 寛、廣田 勇士、山下 公大、松田 武、掛地 吉弘
    第44回日本肥満学会・第41回日本肥満症治療学会学術集会, Japanese, 東北大学大学院医学系研究科 糖尿病代謝内科学分野・岩手医科大学医学部内科学講座 糖尿病・代謝・内分泌内科分野, 仙台, Japan, Domestic conference
    Poster presentation

  • 深層学習アルゴリズムに基づくイメージングサイトメトリーを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索
    安達 祐里、山下 公大、長坂 暢、澤田 隆一郎、長谷川 寛、松田 武、加藤 喬、小寺澤 康文、原田 仁、裏川 直樹、後藤 裕信、金治 新悟、押切 太郎、掛地 吉弘
    第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, Japan, Domestic conference
    Public symposium

  • 放射線治療において抗腫瘍効果に寄与する腫瘍内CD8+T細胞の動態
    阿部 智喜、山下 公大、向山 知佑、安藤 正恭、常城 宇生、安達 祐里、斎藤 雅史、加藤 喬、澤田 隆一郎、小寺澤 康文、原田 仁、裏川 直樹、後藤 裕信、長谷川 寛、金治 新悟、松田 武、押切 太郎、掛地 吉弘
    第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, Japan, Domestic conference
    Public symposium

  • 高齢者に対する食道切除後の腸瘻チューブ留置による栄養介入の重要性
    加藤 喬、押切 太郎、小寺澤 康文、後藤 裕信、澤田 隆一郎、原田 仁、裏川 直樹、長谷川 寛、金治 新悟、山下 公大、松田 武、掛地 吉弘
    第74回日本気管食道科学会総会ならびに学術講演会, Japanese, 独立行政法人国立病院機構 九州がんセンター 消化管外科, 福岡, Japan, Domestic conference
    Oral presentation

  • リンパ節郭清個数からみるMinimally invasive esophagectomyにおける上縦隔リンパ節郭清の重要性
    小寺澤 康文、加藤 喬、押切 太郎、澤田 隆一郎、原田 仁、裏川 直樹、後藤 裕信、長谷川 寛、金治 新悟、山下 公大、松田 武、掛地 吉弘
    第74回日本気管食道科学会総会ならびに学術講演会, Japanese, 独立行政法人国立病院機構 九州がんセンター 消化管外科, 福岡, Japan, Domestic conference
    Oral presentation

  • 十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同⼿術における結腸間膜尾側からの腹腔鏡アプローチの有⽤性の検討
    原田 仁、金治 新悟、澤田 隆一郎、小寺澤 康文、裏川 直樹、後藤 裕信、長谷川 寛、山下 公大、松田 武、掛地 吉弘
    第26回腹腔鏡内視鏡合同手術研究会, Japanese, 神戸大学 食道胃腸外科・神戸大学 国際がん医療・研究センター 消化器内科, 神戸, Japan, Domestic conference
    Oral presentation

  • Clinical Significance of SUVmax on FDG-PET to Predict Treatment Response and Outcomes in Patients with Rectal Cancer Undergoing NACRT
    Tsuneki T, Matsuda T, Sawada R, Hasegawa R, Yamashita K, Koterazawa Y, Harada H, Urakawa N, Goto H, Kanaji S, Kakeji Y
    IASGO-CME Advanced Post-Graduate Course in Kobe 2023, English, Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Graduate School of Medicine, Kobe University, Kobe, Japan, International conference
    Poster presentation

  • The advantage of geriatric nutritional risk index as a prognostic indicator for elderly patients with early gastric cancer after noncurative endoscopic resection
    Shimada A, Harada H, Kanaji S, Sawada R, Koterazawa Y, Urakawa N, Goto H, Hasegawa H, Yamashita K, Matsuda T, Kakeji Y
    IASGO-CME Advanced Post-Graduate Course in Kobe 2023, English, Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Graduate School of Medicine, Kobe University, Kobe, Japan, International conference
    Poster presentation

  • The significance of geriatric nutritional risk index as a prognostic factor for early gastric cancer in elderly patients after non-curative endoscopic resection
    Harada H, Kanaji S, Sawada R, Koterazawa Y, Urakawa N, Goto H, Hasegawa H, Yamashita K, Matsuda T, Oshikiri T, Kakeji Y
    The 3rd International Congress of the Asian Oncology Society (AOS2023), English, Department of Urology, Keio University School of Medicin, Yokohama, Japan, International conference
    Oral presentation

  • Albumin and derived neutrophil-to-lymphocyte ratio is a novel prognostic factor for patients with esophageal squamous cell carcinoma
    Abe T, Oshikiri T, Goto H, Koterazawa Y, Kato T, Sawada R, Harada H, Urakawa N, Hasegawa H, Kanaji S, Yamashita K, Matsuda T, Kakeji Y
    The 3rd International Congress of the Asian Oncology Society (AOS2023), English, Department of Urology, Keio University School of Medicin, Yokohama, Japan, International conference
    Oral presentation

  • 下部直腸癌に対するTaTMEの有用性とラーニングカーブ
    澤田 隆一郎、松田 武、山下 公大、長谷川 寛、小寺澤 康文、原田 仁、裏川 直樹、後藤 裕信、金治 新悟、押切 太郎、掛地 吉弘
    第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conference
    Public symposium

  • リンパ節転移比率からみるMinimally invasive esophagectomyにおける上縦隔リンパ節郭清の重要性
    小寺澤 康文、押切 太郎、澤田 隆一郎、原田 仁、裏川 直樹、後藤 裕信、長谷川 寛、金治 新悟、山下 公大、松田 武、掛地 吉弘
    第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conference
    Public symposium

  • 当院におけるロボット支援下結腸切除術の導入 10例の経験
    長谷川 寛、松田 武、澤田 隆一郎、山下 公大、小寺澤 康文、原田 仁、裏川 直樹、後藤 裕信、金治 新悟、押切 太郎、掛地 吉弘
    第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conference
    Public symposium

  • The advantage of geriatric nutritional risk index as a prognostic indictor for elderly patients with early gastric cancer after non-curative endoscopic resection
    Imai M, Harada H, Kanaji S, Sawada R, Koterazawa Y, Urakawa N, Goto H, Hasegawa H, Yamashita K, Matsuda T, Oshikiri T, Kakeji Y
    The Korea International Gastric Cancer Week 2023 (KINGCA WEEK 2023), English, The Korean Gastric Cancer Association, Seoul, Korea, Republic of, International conference
    Oral presentation

  • Efficacy of 18F-fluoro-2-deoxyglucose positron emission tomography as a predictor of treatment response to neoadjuvant chemotherapy for gastric cancer
    Yokoo H, Urakawa N, Kato T, Sawada R, Koterazawa Y, Harada H, Goto H, Hasegawa H, Kanaji S, Yamashita K, Matsuda T, Oshikiri T, Kakeji Y
    The Korea International Gastric Cancer Week 2023 (KINGCA WEEK 2023), English, The Korean Gastric Cancer Association, Seoul, Korea, Republic of, International conference
    Oral presentation

  • 深層学習に基づくイメージサイトメトリーによる直腸癌の新規予後因子の探索
    山下 公大、長坂 暢、澤田 隆一郎、長谷川 寛、松田 武、小寺澤 康文、裏川 直樹、後藤 裕信、金治 新悟、押切 太郎、掛地 吉弘
    第33回日本サイトメトリー学会学術集会, Japanese, 杏林大学大学院医学研究科 共同研究施設フロ−サイトメトリ−部門, Web, Japan, Domestic conference
    Poster presentation

  • 下部直腸癌に対するTaTMEの有用性とラーニングカーブ
    澤田 隆一郎、松田 武、山下 公大、長谷川 寛、小寺澤 康文、原田 仁、裏川 直樹、後藤 裕信、金治 新悟、押切 太郎、掛地 吉弘
    第99回大腸癌研究会学術集会, Japanese, 関西労災病院 外科, 尼崎, Japan, Domestic conference
    Oral presentation

  • 高齢者食道癌患者に対する胸腔鏡下食道切除術
    安達 祐里、後藤 裕信、押切 太郎、加藤 喬、小寺澤 康文、澤田 隆一郎、原田 仁、裏川 直樹、長谷川 寛、金治 新悟、山下 公大、松田 武、掛地 吉弘
    第66回関西胸部外科学会学術集会, Japanese, JCHO大阪病院, 大阪, Japan, Domestic conference
    Others

  • 進行食道癌に対するロボット支援下食道切除
    後藤 裕信、押切 太郎、加藤 喬、小寺澤 康文、澤田 隆一郎、原田 仁、裏川 直樹、長谷川 寛、金治 新悟、山下 公大、松田 武、掛地 吉弘
    第66回関西胸部外科学会学術集会, Japanese, JCHO大阪病院, 大阪, Japan, Domestic conference
    Public symposium

  • Routine Placement of Feeding Jejunostomy Tube During Esophagectomy Increases Postoperative Complications and Does Not Improve Postoperative Malnutrition
    Koterazawa Y
    18th ISDE World Congress for Esophageal Diseases, English, International Society for Diseases of the Esophagus, Web, Japan, International conference
    Oral presentation

  • レチノイン酸レセプターγはヒトiPS細胞から食道上皮への分化誘導を促進する
    小寺澤 康文、小柳 三千代、押切 太郎、掛地 吉弘、青井 貴之
    第72回日本気管食道科学会総会ならびに学術講演会, Japanese, 大分大学呼吸器・乳腺外科学講座, web開催, Japan, Domestic conference
    Public symposium

  • 胸部食道癌術後にsevereな体重減少を認める症例は予後不良であり、周術期に短期的な経腸栄養を行っても改善しない
    小寺澤 康文、押切 太郎、瀧口 豪介、裏川 直樹、長谷川 寛、金治 新悟、松田 佳子、山下 公大、松田 武、中村 哲、鈴木 知志、掛地 吉弘
    第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conference
    Poster presentation

  • When should esophagectomy be performed to non-curative superficial esophageal cancer after endoscopic resection?
    Ishida S, Nakamura T, Koterazawa Y, Takiguchi G, Urakawa N, Hasegawa H, Yamamoto M, Kanaji S, Matsuda Y, Yamashita K, Matsuda T, Oshikiri T, Suzuki S, Kakeji Y
    7th FACO Academic Conference, English, Chinese Society of Clinical Oncology, shanghai, China, International conference
    Poster presentation

  • 胸部食道癌に対し予防的頸部リンパ節郭清は省略可能か
    小寺澤 康文、押切 太郎、高橋 理彦、山本 将士、金治 新悟、山下 公大、松田 武、中村 哲、鈴木 知志、掛地 吉弘
    第30回日本消化器癌発生学会総会, Japanese, 一般社団法人 日本消化器癌発生学会, 横浜, Japan, Domestic conference
    Public symposium

  • 内視鏡治療後非治癒切除症例に対する食道切除術の意義と適応
    中村 哲、小寺澤 康文、瀧口 豪介、裏川 直樹、長谷川 寛、山本 将士、田中 心和、金治 新悟、松田 佳子、山下 公大、森田 圭紀、松田 武、押切 太郎、鈴木 知志、掛地 吉弘
    第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conference
    Public symposium

  • 胃管癌に対する低侵襲治療
    堀江 和正、中村 哲、小寺澤 康文、三浦 晋、瀧口 豪介、長谷川 寛、松田 佳子、山本 将士、金治 新悟、山下 公大、松田 武、押切 太郎、鈴木 知志、掛地 吉弘
    第28回消化器疾患病態治療研究会, Japanese, 愛知医科大学 消化管内科, 名古屋, Japan, Domestic conference
    Others

  • 85歳以上の高齢者胃癌手術症例に対する治療成績の検討
    小寺澤 康文、幕内 梨恵、速水 克、熊谷 厚志、佐野 武、布部 創也
    日本消化器外科学会, Japanese
    Public symposium

  • 胸部食道癌に対し予防的頸部リンパ節郭清は全例に必要か；予防的頸部郭清省略の検討
    小寺澤 康文、押切 太郎、長谷川 寛、山本 将士、金治 新悟、山下 公大、松田 武、中村 哲、鈴木 知志、掛地 吉弘
    第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conference
    Others

  • 胸部食道癌手術において経腸栄養tubeは前例に必要か？
    小寺澤 康文
    神戸消化器外科懇話会分科会, Japanese, 株式会社大塚製薬工場/イーエヌ大塚製薬株式会社, 神戸, Japan, Domestic conference
    Oral presentation

  • 胸部食道癌に対し予防的頸部リンパ節郭清は全例に必要か
    小寺澤 康文、押切 太郎、瀧口 豪介、長谷川 寛、山本 将士、金治 新悟、松田 佳子、山下 公大、松田 武、中村 哲、鈴木 知志、掛地 吉弘
    第28回日本癌病態治療研究会, Japanese, 埼玉医科大学総合医療センター 消化管・一般外科/ゲノム診療科, 川越, Japan, Domestic conference
    Public symposium

  • All-trans-レチノイン酸はヒトiPS細胞から食道上皮への分化誘導を促進する
    小寺澤 康文、押切 太郎、中村 哲、小柳 美千代、掛地 吉弘、青井 貴之
    第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conference
    Poster presentation

  • 食道切除再建術における経腸栄養tube留置の意義
    瀧口 豪介、押切 太郎、小寺澤 康文、三浦 晋、山本 将士、金治 新悟、松田 佳子、中村 哲、鈴木 知志、掛地 吉弘
    第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conference
    Poster presentation

  • ロボット支援下食道切除術の導入と初期治療成績
    中村 哲、小寺澤 康文、青木 丈明、瀧口 豪介、三浦 晋、山本 将士、金治 新悟、松田 武、鈴木 知志、掛地 吉弘
    第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conference
    Poster presentation

  • Routine placement of feeding jejunostomy tube during thoracoscopic esophagectomy increases postoperative complications and does not improve postoperative malnutrition
    Koterazawa Y, Oshikiri T, Hasegawa H, Yamamoto M, Kanaji S, Yamashita K, Matsuda T, Nakamura T, Suzuki S, Kakeji Y
    Korean Society of Endoscopic & Laparoscopic Surgeons, English
    Poster presentation

  • 胸部食道癌手術において経腸栄養tube は全例に必要か？
    小寺澤 康文、押切 太郎、長谷川 寛、山本 将士、金治 新悟、松田 佳子、山下 公大、松田 武、中村 哲、鈴木 知志、掛地 吉弘
    第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conference
    Poster presentation

  • リプログラミング因子を用いた人工骨肉腫幹細胞株の樹立
    藤原 周一、河本 旭哉、川上 洋平、小寺澤 康文、原 仁美、深瀬 直政、竹森 俊幸、北山 和道、秋末 敏宏、青井 貴之、黒田 良祐
    第2回日本サルコーマ治療研究学会学術集会, Japanese, 公益財団法人がん研究会有明病院 総合腫瘍科, 東京, Japan, Domestic conference
    Poster presentation

  • 内視鏡治療後非治癒切除症例に対する食道切除術の適応
    中村 哲、小寺澤 康文、掛地 吉弘
    JDDW2018（第26回日本消化器関連学会週間）, Japanese, 一般社団法人 日本消化器関連学会機構, 神戸, Japan, Domestic conference
    Others

  • A comparison of the clinical outcomes of esophagectomy and chemoradiotherapy after noncurative endoscopic submucosal dissection for esophageal squamous cell carcinoma
    Koterazawa Y, Nakamura T, Oshikiri T, Kanaji S, Tanaka S, Ishida T, Yamashita K, Matsuda T, Morita Y, Suzuki S, Kakeji Y
    ISDE world Congress for Esophageal Disease, English
    Oral presentation

  • Comparison of the clinical outcomes of esophagectomy  and chemoradiotherapy after noncurative endoscopic submucosal dissection for esophageal squamous cell carcinoma
    Koterazawa Y, Nakamura T, Oshikiri T, Kanaji S, Yamashita K, Matsuda T, Suzuki S, Kakeji Y
    The international society for Diseases of the Esophagus (ISDE), English, International Society for Diseases of the Esophagus, Vienna, Austria, International conference
    Oral presentation

  • 胸部食道癌手術において経腸栄養tube留置は省略できるか?
    小寺澤 康文、押切 太郎、 中村 哲、 長谷川 寛、 山本 将士、 金治 新悟、 山下 公大、 松田 武、 鈴木 知志、 掛地 吉弘
    第73回日本消化器外科学会総会, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Japan, Domestic conference
    Poster presentation

  • 胸部食道癌手術において経腸栄養tubeは全例に必要か？
    小寺澤 康文、押切 太郎、中村 哲、長谷川 寛、山本 将士、金治 新悟、山下 公大、松田 武、鈴木 知志、掛地 吉弘
    第72回日本食道学会学術集会, Japanese, 特定非営利活動法人 日本食道学会, 宇都宮, Japan, Domestic conference
    Poster presentation

  • 胸腔鏡下食道切除術に対する３Ｄ内視鏡の導入と治療成績
    中村 哲、小寺澤 康文、澤田 隆一郎、池田 太郎、渋谷 尚樹、青木 丈明、三浦 由紀子、原田 仁、中川 暁雄、西 将康、長谷川 寛、山本 将士、金治 新悟、松田 佳子、山下 公大、松田 武、押切 太郎、角 泰雄、鈴木 知志、掛地 吉弘
    第118回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 東京, Japan, Domestic conference
    Others

  • 食道癌内視鏡的粘膜下層剥離術後非治療切除症例に対する追加治療例の検討
    小寺澤 康文、中村 哲、長谷川 寛、山本 将士、金治 新悟、松田 佳子、山下 公大、松田 武、押切 太郎、角 泰雄、鈴木 知志、掛地 吉弘
    第118回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 東京, Japan, Domestic conference
    Others

  • 内視鏡的粘膜下層剥離術後非治癒切除症例に対する食道切除の意義とその役割
    小寺澤 康文、中村 哲、押切 太郎、鈴木 知志、掛地 吉弘
    第55回日本癌治療学会学術総会, Japanese, 兵庫医科大学外科, 横浜, Japan, Domestic conference
    Poster presentation

  • 腹腔鏡下食道亜全摘術を施行した食道炎症性腫瘤の1例
    澤田 隆一郎、押切 太郎、小寺澤 康文、松田 佳子、山下 公大、松田 武、角 泰雄、中村 哲、鈴木 知志、掛地 吉弘
    第30回近畿内視鏡外科研究会, Japanese, 京都大学 医学部 消化管外科, 大阪, Japan, Domestic conference
    Oral presentation

  • 炎症性食道腫瘤の1例
    澤田 隆一郎、押切 太郎、小寺澤 康文、三浦 由紀子、長谷川 寛、山本 将士、金治 新悟、松田 佳子、松田 武、角 泰雄、中村 哲、鈴木 知志、掛地 吉弘
    第200回近畿外科学会, Japanese, 近畿外科学会, 京都, Japan, Domestic conference
    Oral presentation

  • 縫合不全に対し食道ステントが有効であったイマチニブ投与後食道GISTの1例
    小寺澤 康文、中村 哲
    第60回関西胸部外科学会学術集会, Japanese, 兵庫医科大学 心臓血管外科, 大阪, Japan, Domestic conference
    Others

  • 内視鏡的粘膜下層剥離術後非治療切除症例に対する食道切除の意義とその役割
    小寺澤 康文、中村 哲、福岡 英志、山本 将士、金治 新悟、山下 公大、松田 武、押切 太郎、角 泰雄、鈴木 知志、掛地 吉弘
    第26回癌病態治療研究会, Japanese, 株式会社プランニングウィル, 横浜, Japan, Domestic conference
    Public symposium

  • 一般演題②
    小寺澤 康文
    第74回 阪神食道疾患検討会, Japanese, 阪神食道疾患検討会・日本化薬株式会社, 大阪, Japan, Domestic conference
    Oral presentation

■ Research Themes
  • OSNA法を用いた切除組織端に対する術中迅速病理診断の開発
    小寺澤 康文
    日本学術振興会, 科学研究費助成事業, 若手研究, 神戸大学, 01 Apr. 2024 - 31 Mar. 2026

  • Differentiation of human induced pluripotent stem cells into Barret esophageal epithelium
    Koterazawa Yasufumi
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Kobe University, Apr. 2019 - Mar. 2021
    The mechanisms regulating esophageal differentiation remain unclear. In particular, the details of the human esophagus itself have been poorly researched. In this decade, studies using human induced pluripotent stem cells (hiPSCs) have proven powerful tools for clarifying the developmental biology of various human organs. We established a novel stepwise protocol with transwell culture and an airliquid interface system for esophageal epithelial cell (EEC) differentiation from hiPSCs. We successfully generated stratified layers of cells expressing EEC marker genes that were positive for lugol staining. We then evaluated the effect of all-trans retinoic acid (ATRA), which is a retinoic acid receptor (RAR)α, RARβ and RARγ agonist, on the differentiation from the hiPSC-derived foregut. The enhancing effect of ATRA on EEC differentiation was clearly demonstrated. Finally, we revealed that RARγ activation promotes the differentiation of hiPSCs-derived foregut into EECs.

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