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KOTERAZAWA YasufumiUniversity Hospital / Gastrointestinal SurgeryAssistant Professor
Research activity information
■ Paper- Anticancer Research USA Inc., Dec. 2024, Anticancer Research, 44(12) (12), 5485 - 5493Scientific journal
- Elsevier BV, Dec. 2024, Journal of Gastrointestinal Surgery, 101934 - 101934Scientific journal
- Elsevier BV, Dec. 2024, Journal of Gastrointestinal Surgery, 28(12) (12), 2001 - 2007Scientific journal
- Abstract Background Esophagectomy with lymphadenectomy is the primary treatment for esophageal squamous cell carcinoma (ESCC). However, intensive dissection of lymph nodes (LNs) along the recurrent laryngeal nerve (RLN) is associated with RLN palsy and pulmonary complications leading to poor survival. Therefore, this study aimed identify the risk factors for LNs metastasis along the RLN in patients with ESCC. Methods The present study included 168 patients with lower thoracic esophageal and esophagogastric junction (EGJ) squamous cell carcinoma who underwent esophagectomy with total mediastinal lymphadenectomy at Kobe University Hospital. Left/Right cervical paraesophageal (101 L/R), left/right recurrent nerve (106 recL/R), and left tracheobronchial LNs (106 tbL) were defined as LNs along the RLN. We evaluated the pathological distance between the proximal tumor boundary and the EGJ using images of the fixed specimen (PB‐EGJ length). Results LN metastasis along the RLN was observed in 19 (11%) patients. The percentage of patients with a longer PB‐EGJ length and cLNs metastasis was higher in the LNs metastasis along the RLN positive‐group than in the RLN‐negative group (p = 0.0075 and p = 0.013, respectively). The incidence of LNs metastasis along the RLN was 0% (95% confidence interval [CI] = 0–7.7%) when the PB‐EGJ length was <4 cm. Univariate analysis showed that patients with cLNs metastasis negative had a low risk for LNs metastasis along the RLN (odds ratio = 0.26 and 95% CI = 0.083–0.82). Conclusions Patients with a PB‐EGJ length <4 cm and negative for cLNs metastasis may be candidates for the omission of lymphadenectomy along the RLN.Lead, Wiley, Nov. 2024, World Journal of SurgeryScientific journal
- Springer Science and Business Media LLC, Sep. 2024, Surgery TodayScientific journal
- Springer Science and Business Media LLC, Sep. 2024, Esophagus, 22(1) (1), 59 - 67Scientific journal
- Springer Science and Business Media LLC, Jun. 2024, Surgery TodayScientific journal
- Springer Science and Business Media LLC, Jun. 2024, Langenbeck's Archives of Surgery, 409(1) (1)Scientific journal
- Springer Science and Business Media LLC, May 2024, Surgical Endoscopy, 38(7) (7), 3625 - 3635Scientific journal
- (株)日本臨床社, May 2024, 日本臨床, 82(増刊3 食道癌2024) (増刊3 食道癌2024), 532 - 536, Japanese
- Background In Japan, preoperative adjuvant chemotherapy followed by surgical resection is the standard treatment for patients with locally advanced esophageal squamous cell carcinoma. However, the risk of recurrence after surgical resection remains high. Although a randomized controlled trial evaluating the efficacy of nivolumab, a fully human monoclonal anti-programmed death 1 antibody, as postoperative adjuvant therapy after neoadjuvant chemoradiotherapy and surgery established its superior efficacy as adjuvant therapy, the efficacy for patients who received preoperative adjuvant chemotherapy has not been demonstrated. This study aims to elucidate the efficacy and safety of nivolumab as postoperative adjuvant therapy for patients with esophageal squamous cell carcinoma after preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. Methods This study is a multi-institutional, single-arm, Phase II trial. We plan to recruit 130 esophageal squamous cell carcinoma patients, who have undergone preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. If the patient did not have a pathological complete response, nivolumab is started as a postoperative adjuvant therapy within 4–16 weeks after surgery. The nivolumab dose is 480 mg/day every four weeks. Nivolumab is administered for up to 12 months. The primary endpoint is disease-free survival; the secondary endpoints are overall survival, distant metastasis-free survival, and incidence of adverse events. Discussion To our knowledge this study is the first trial establishing the efficacy of nivolumab as postoperative adjuvant therapy for patients with esophageal squamous cell carcinoma after preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. In Japan, preoperative adjuvant chemotherapy followed by surgery is a well-established standard treatment for resectable, locally advanced esophageal squamous cell carcinoma. Therefore, developing an effective postoperative adjuvant therapy has been essential for improving oncological outcomes.Public Library of Science (PLoS), Apr. 2024, PLOS ONE, 19(4) (4), e0299742 - e0299742Scientific journal
- Lead, Springer Science and Business Media LLC, Feb. 2024, Annals of Surgical Oncology, 31(6) (6), 4018 - 4018Scientific journal
- (株)日本臨床社, Jan. 2024, 日本臨床, 82(増刊1 ロボット支援手術) (増刊1 ロボット支援手術), 163 - 169, Japanese
- Lead, Springer Science and Business Media LLC, Dec. 2023, Annals of Surgical Oncology, 31(4) (4), 2482 - 2489Scientific journal
- Springer Science and Business Media LLC, Dec. 2023, Surgery TodayScientific journal
- Lead, Springer Science and Business Media LLC, May 2023, Gastric Cancer, 26(5) (5), 823 - 832Scientific journal
- Lead, Springer Science and Business Media LLC, Feb. 2023, Gastric Cancer, 26(3) (3), 451 - 459Scientific journal
- Lead, Springer Science and Business Media LLC, May 2022, Gastric Cancer, 25(5) (5), 973 - 981Scientific journal
- Objective: To identify the minimum length of esophageal resection to ensure a pathologically negative proximal margin (PM) in total gastrectomy for gastric cancer. Background: In total gastrectomy, a certain esophageal length is resected to obtain a pathologically negative PM because of the possibility of unexpected pathological esophageal invasion. However, a recommendation regarding the esophageal transection site in total gastrectomy has not been established. Methods: The data of patients who underwent total gastrectomy for gastric cancer from 2005 to 2018 were collected. We evaluated the length of unexpected pathological esophageal invasion (esophageal ΔPM) in each type of disease and each location of the gross proximal tumor boundary (PB) using the length between the PB and the esophagogastric junction (PB-EGJ length). Results: Of the 1005 patients eligible for this study, 277, 196, and 532 had cT1, cT2–4 expansive (Exp), and cT2–4 infiltrative (Inf) growth patterns, respectively. In cT1 and Exp, no unexpected pathological esophageal invasion occurred when the PB-EGJ length was >1 cm, whereas pathological esophageal invasion occurred in 20.0% of cT1 and 32.7% of Exp when the PB-EGJ length was ≤1 cm. The esophageal ΔPM was <1 cm. In Inf, no unexpected pathological esophageal invasion occurred when the PB-EGJ length was >3 cm, whereas pathological esophageal invasion occurred in 17.4% of patients when the PB-EGJ length was ≤3 cm. The esophageal ΔPM was <2 cm. Conclusions: New recommendations regarding the esophageal resection length required to ensure a pathologically negative PM in total gastrectomy are herein proposed.Lead, Ovid Technologies (Wolters Kluwer Health), Jan. 2022, Annals of Surgery Open, 3(1) (1), e127 - e127Scientific journal
- Abstract Background Patients often experience severe weight loss after oesophagectomy. Enteral nutrition via a feeding jejunostomy tube (FT) is commonly practised. This study aimed to assess the effect of severe weight loss postoperatively and enteral nutrition via an FT on long-term prognosis after oesophagectomy. Methods This study analysed 317 patients who underwent minimally invasive oesophagectomy at Kobe University Hospital and Hyogo Cancer Center from 2010 to 2015. The patients’ body weight was evaluated at 3 months postoperatively. They were organised into the severe weight loss (n = 65) and moderate weight loss (n = 252) groups. Furthermore, they were categorised into the FT group (184 patients who had an FT placed during oesophagectomy) and no-FT group (133 patients without FT). Patients (119 per group) matched for the FT and no-FT groups were identified via propensity score matching. Results The 5-year overall survival (OS) rate in the severe weight loss group was significantly lower (p = 0.024). In the multivariate analysis, tumour invasion depth (pT3-4), preoperative therapy and severe weight loss had a worse OS (hazard ratio = 1.89; 95% confidence interval = 1.12–3.17, hazard ratio = 2.11; 95% confidence interval = 1.25–3.54, hazard ratio = 1.82; 95% confidence interval = 1.02–3.524, respectively). No significant differences in the number of severe weight loss patients and OS were found between the FT and no-FT groups. Conclusion Severe weight loss is significantly associated with poor OS. In addition, enteral nutrition via an FT did not improve the severe weight loss and OS.Lead, Springer Science and Business Media LLC, Dec. 2020, BMC Gastroenterology, 20(1) (1)Scientific journal
- Abstract Background Cancer stem cells (CSCs) are considered to be responsible for tumor initiation, formation, and poor prognosis of cancer patients. However, the rarity of CSCs in clinical samples makes it difficult to elucidate characteristics of CSCs, especially in osteosarcoma (OS). The aim of this study is to verify whether it is possible to generate CSC-like cells by transducing defined factors into an OS cell line. Methods We retrovirally transduced the Octamer-binding transcription factor 3/4 (OCT3/4), Kruppel-like factor 4 (KLF4), and SRY-box transcription factor 2 (SOX2) genes into the MG-63 human OS cell line (MG-OKS). Parental and GFP-transduced MG-63 cells were used as negative control. We assessed the properties of the generated cells in vitro and in vivo. Multiple comparisons among groups were made using a one-way analysis of variance (ANOVA) followed by post hoc testing with Tukey’s procedure. Results MG-OKS cells in vitro exhibited the significantly increased mRNA expression levels of CSC markers (CD24,CD26, andCD133), decreased cell growth, increased chemoresistance and cell migration, and enhanced sphere formation. Notably, MG-OKS cells cultured under osteogenic differentiation conditions showed strongly positive staining for both Alizarin Red S and alkaline phosphatase, indicating osteogenesis of the cells. Gene ontology analysis of microarray data revealed significant upregulation of epidermal-related genes. Tumors derived from MG-OKS cells in vivo were significantly larger than those from other cells in μCT analysis, and immunohistochemical staining showed that Ki-67, osteocalcin, and HIF-1α-positive cells were more frequently detected in the MG-OKS-derived tumors. Conclusions In this study, we successfully generated OS CSC-like cells with significantly enhanced CSC properties following transduction of defined factors.Springer Science and Business Media LLC, Oct. 2020, Stem Cell Research & Therapy, 11(1) (1)Scientific journal
- In the original publication of the article, the following errors were noted and corrected in this correction.Oct. 2020, Journal of gastroenterology, 55(10) (10), 1010 - 1011, English, Domestic magazine
- INTRODUCTION: Recent advances in the treatment for esophageal cancer have improved the prognosis after esophagectomy, but they have led to an increased incidence of gastric tube cancer. In most patients who underwent retrosternal reconstruction, median sternotomy is performed; it is associated with a risk of postoperative bleeding and osteomyelitis, and pain often negatively affects respiration. Here, we report the first case of thoracoscopic retrosternal gastric conduit resection in the supine position (TRGR-S). MATERIALS AND SURGICAL TECHNIQUE: A 75-year-old male patient was placed in the supine position. Four ports were placed in the left chest wall. The gastric tube was separated from the epicardium, sternum, and left brachiocephalic vein. Because of adhesions between the gastric tube and the right pleura, combined resection of the right pleura was performed. The dorsal side of the gastric tube was dissected before the ventral side, enabling the gastric tube to be suspended from the back of the sternum and, thus, making it easier to expose the surgical field. Next, pedicled jejunal reconstruction via the presternal route was performed. There were no postoperative complications. The pathological diagnosis was signet ring cell carcinoma (pT1b, pN0, M0, pStage I), indicating R0 resection. DISCUSSION: TRGR-S does not require sternotomy, reducing the risk of postoperative bleeding and osteomyelitis. In the presence of adhesions, TRGR-S is safe and provides a good surgical view. It is also reliable procedure for resection of retrosternal gastric tube cancer, and it is ergonomic for surgeons.Jul. 2020, Asian journal of endoscopic surgery, 13(3) (3), 461 - 464, English, Domestic magazineScientific journal
- Abstract Background The esophagus is known to be derived from the foregut. However, the mechanisms regulating this process remain unclear. In particular, the details of the human esophagus itself have been poorly researched. In this decade, studies using human induced pluripotent stem cells (hiPSCs) have proven powerful tools for clarifying the developmental biology of various human organs. Several studies using hiPSCs have demonstrated that retinoic acid (RA) signaling promotes the differentiation of foregut into tissues such as lung and pancreas. However, the effect of RA signaling on the differentiation of foregut into esophagus remains unclear. Methods We established a novel stepwise protocol with transwell culture and an air–liquid interface system for esophageal epithelial cell (EEC) differentiation from hiPSCs. We then evaluated the effect of all-trans retinoic acid (ATRA), which is a retinoic acid receptor (RAR)α, RARβ and RARγ agonist, on the differentiation from the hiPSC-derived foregut. Finally, to identify which RAR subtype was involved in the differentiation, we used synthetic agonists and antagonists of RARα and RARγ, which are known to be expressed in esophagus. Results We successfully generated stratified layers of cells expressing EEC marker genes that were positive for lugol staining. The enhancing effect of ATRA on EEC differentiation was clearly demonstrated with quantitative reverse transcription polymerase chain reaction, immunohistology, lugol-staining and RNA sequencing analyses. RARγ agonist and antagonist enhanced and suppressed EEC differentiation, respectively. RARα agonist had no effect on the differentiation. Conclusion We revealed that RARγ activation promotes the differentiation of hiPSCs-derived foregut into EECs.Lead, Springer Science and Business Media LLC, Jun. 2020, Journal of Gastroenterology, 55(8) (8), 763 - 774Scientific journal
- Lead, Springer Science and Business Media LLC, Jun. 2019, Annals of Surgical Oncology, 26(9) (9), 2899 - 2904Scientific journal
- Lead, Oxford University Press (OUP), Apr. 2019, Diseases of the EsophagusScientific journal
- Lead, (公社)日本医師会, Jan. 2019, 日本医師会雑誌, 147(10) (10), 1996 - 1996, Japanese【機能性消化管疾患診療の実際】嚥下障害・つまり感があれば器質性疾患に注意
- Lead, May 2018, 消化器外科NURSING, 23(5) (5), 64 - 65, Japanese第5回 食道がんに用いられる抗がん剤(消化器外科おくすりメモ)
- Lead, Apr. 2018, 消化器外科NURSING, 23(4) (4), 68 - 69, Japanese第4回 食道がんに用いられる抗がん剤(消化器外科おくすりメモ)
- Lead, Springer Science and Business Media LLC, Mar. 2018, Surgery Today, 48(8) (8), 783 - 789Scientific journal
- Lead, Japan Surgical Association, 2017, Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 78(3) (3), 536 - 541Scientific journal
- (一社)日本消化器外科学会, Aug. 2016, 日本消化器外科学会雑誌, 49(8) (8), 707 - 713, Japanese
- (一社)日本消化器外科学会, Jan. 2016, 日本消化器外科学会雑誌, 49(1) (1), 29 - 35, Japanese
- Lead, 2016, 腹部救急医学会雑誌, 36(4) (4), 813 - 817胆嚢捻転症の6手術例
- (一社)日本内視鏡外科学会, Dec. 2015, 日本内視鏡外科学会雑誌, 20(7) (7), OS278 - 3, Japanese門脈腫瘍栓を伴う転移性肝癌に対して腹腔鏡下肝部分切除術を施行した左側胆嚢の1症例
- 日本臨床外科学会, Oct. 2015, 日本臨床外科学会雑誌, 76(増刊) (増刊), 711 - 711, Japanese当科における大腸癌の穿孔例の検討
- 日本臨床外科学会, Oct. 2015, 日本臨床外科学会雑誌, 76(増刊) (増刊), 829 - 829, Japanese胃癌術後の異時性孤立性脾転移とS状結腸癌に対して腹腔鏡下に脾摘術とS状結腸切除術を施行した1例
- 日本臨床外科学会, Oct. 2015, 日本臨床外科学会雑誌, 76(増刊) (増刊), 852 - 852, JapaneseRhabdoid featureを呈した巨大横行結腸癌の1例
- (NPO)日本食道学会, Jul. 2015, 日本食道学会学術集会プログラム・抄録集, 69回, 100 - 100, Japanese腹腔鏡下胃管再建術は術後の横隔膜ヘルニアを助長するか
- (一社)日本外科学会, Apr. 2015, 日本外科学会定期学術集会抄録集, 115回, OP - 2, Japanese上部消化管 用手補助(HALS)を用いない腹腔鏡補助下胃管作成術の検討
- Lead, 日本臨床外科学会, Dec. 2014, 日本臨床外科学会雑誌, 75(12) (12), 3369 - 3374, Japanese
- 日本臨床外科学会, Oct. 2014, 日本臨床外科学会雑誌, 75(増刊) (増刊), 613 - 613, Japanese嚢胞内腫瘍を呈した両側乳腺葉状腫瘍の1例
- 日本臨床外科学会, Oct. 2014, 日本臨床外科学会雑誌, 75(増刊) (増刊), 749 - 749, Japanese潰瘍性大腸炎穿孔後に人工肛門周囲に発症した壊疽性膿皮症の治療に難渋した1例
- (一社)日本内視鏡外科学会, Oct. 2014, 日本内視鏡外科学会雑誌, 19(7) (7), 447 - 447, JapaneseS状結腸癌に対する腹腔鏡下S状結腸切除術(SRA温存D2廓清)
- (一社)日本内視鏡外科学会, Oct. 2014, 日本内視鏡外科学会雑誌, 19(7) (7), 448 - 448, Japanese後期研修医による腹腔鏡下結腸右半切除術
- (一社)日本内視鏡外科学会, Oct. 2014, 日本内視鏡外科学会雑誌, 19(7) (7), 825 - 825, Japanese腹腔鏡下幽門側胃切除術術前にダイナミックCT検査が有用であった腸回転異常症の1例
- (一社)日本消化器外科学会, Jul. 2014, 日本消化器外科学会総会, 69回, RV - 5, Japanese当科における腹腔鏡下胃全摘術の再建法の変遷と工夫点に関する検討
- (一社)日本膵臓学会, Jun. 2014, 膵臓, 29(3) (3), 650 - 650, Japanese
- (一社)日本外科学会, Mar. 2014, 日本外科学会雑誌, 115(臨増2) (臨増2), 586 - 586, Japanese
- (一社)日本外科学会, Mar. 2014, 日本外科学会雑誌, 115(臨増2) (臨増2), 828 - 828, Japanese
- (一社)日本内視鏡外科学会, Nov. 2013, 日本内視鏡外科学会雑誌, 18(7) (7), 559 - 559, Japanese当科における腹腔鏡下肝切除術の導入の現状
- (一社)日本内視鏡外科学会, Nov. 2013, 日本内視鏡外科学会雑誌, 18(7) (7), 581 - 581, Japanese当科における腹腔鏡下胃全摘術の現状
- (一社)日本内視鏡外科学会, Nov. 2013, 日本内視鏡外科学会雑誌, 18(7) (7), 649 - 649, Japanese腹腔鏡下左側大腸癌手術における内側アプローチの工夫
- 日本臨床外科学会, Oct. 2013, 日本臨床外科学会雑誌, 74(増刊) (増刊), 591 - 591, Japanese腹腔鏡下直腸低位前方切除術で経肛門ドレーン留置後に憩室穿孔を発症した1例
- 日本臨床外科学会, Oct. 2013, 日本臨床外科学会雑誌, 74(増刊) (増刊), 839 - 839, Japanese食道癌、大腸癌の重複癌に遠隔(肝・肺)転移を認め、完全切除を施行した一例
- 日本臨床外科学会, Oct. 2013, 日本臨床外科学会雑誌, 74(増刊) (増刊), 1028 - 1028, Japanese術前に前区域領域を支配する右副肝管が疑われた胆石症に対して腹腔鏡下胆嚢摘出術を施行した一例
■ Lectures, oral presentations, etc.
- 第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同手術における結腸間膜尾側からのアプローチの有用性の検討Public symposium
- 第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference高齢の胃癌患者に対する術前化学療法の安全性についての検討Oral presentation
- 第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference切除困難な胃GISTに対する術前イマチニブによる補助療法の有用性に関する検討Public symposium
- 第96回日本胃癌学会総会, English, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conferenceThe significance of conversion surgery following chemotherapy for clinical stage IV gastric cancerOral presentation
- 第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference当院における進行胃癌に対するロボット支援下胃切除術の工夫Oral presentation
- 第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference食道胃接合部腺癌に対する腹腔鏡下経裂孔的再建における左横隔膜開放法の有用性Public symposium
- 第56回制癌剤適応研究会, Japanese, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, Japan, Domestic conference術前化学療法を施行した食道癌における腫瘍マーカーと生存転帰の検討Oral presentation
- 第56回制癌剤適応研究会, Japanese, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, Japan, Domestic conference切除不能進行胃癌に対する conversion surgery の周術期化学療法の重要性及び治療成績Public symposium
- 第56回制癌剤適応研究会, Japanese, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, Japan, Domestic conference鼠径リンパ節転移を伴う直腸・肛門管腺癌の術後成績;術前治療と選択的鼠径リンパ節郭清・直腸間膜全切除による治療戦略Oral presentation
- The 19th Annual Academic Surgical Congress, English, Annual Academic Surgical Congress, Washington, D.C., United States, International conferenceClinical Significance of SUVmax on FDG-PET in Patients with Rectal Cancer Undergoing NACRTOral presentation
- 第207回近畿外科学会, Japanese, 関西医科大学 外科学講座, 枚方市, Japan, Domestic conference高齢の胃癌患者に対する術前化学療法の安全性についての検討Oral presentation
- 第207回近畿外科学会, Japanese, 関西医科大学 外科学講座, 枚方市, Japan, Domestic conferenceリンパ節郭清個数からみる MIE における上縦隔リンパ節郭清の重要性Oral presentation
- 日本消化器病学会近畿支部第120回例会, Japanese, 神戸大学大学院医学研究科外科学講座 肝胆膵外科学分野, 神戸, Japan, Domestic conference当院におけるTaTME併用大腸全摘術の手術成績Public symposium
- 第194回兵庫県外科医会学術集会, Japanese, 兵庫県外科医会, 神戸, Japan, Domestic conference十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同手術における結腸間膜尾側からの腹腔鏡アプローチの有用性の検討Oral presentation
- 第36回日本バイオセラピィ学会学術集会総会, Japanese, 昭和大学医学部内科学講座腫瘍内科学部門, 東京, Japan, Domestic conference深層学習アルゴリズムに基づくイメージングサイトメトリーを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索Oral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference安全な Collard 変法吻合を目指した変革と短期成績Oral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference下部進行直腸癌に対する TaTME 併用の有用性とラーニングカーブに関する検討Oral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conferenceロボット支援食道切除における上縦隔リンパ節郭清手技と短期成績Oral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conferenceロボット支援胃切除術におけるリンパ節郭清時間の learning curveOral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference多発リンパ節転移を伴う進行食道癌に対する Minimally invasive esophagectomyOral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference経肛門アプローチ併用による2チーム側方郭清の手術手技と手術成績Public symposium
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference人間工学に基づく「鏡視下クロソイド・カーブ針」の開発Oral presentation
- 第44回日本肥満学会・第41回日本肥満症治療学会学術集会, Japanese, 東北大学大学院医学系研究科 糖尿病代謝内科学分野・岩手医科大学医学部内科学講座 糖尿病・代謝・内分泌内科分野, 仙台, Japan, Domestic conference当院における腹腔鏡下スリーブ状胃切除術の短期治療成績の検討Poster presentation
- 第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, Japan, Domestic conference深層学習アルゴリズムに基づくイメージングサイトメトリーを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索Public symposium
- 第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, Japan, Domestic conference放射線治療において抗腫瘍効果に寄与する腫瘍内CD8+T細胞の動態Public symposium
- 第74回日本気管食道科学会総会ならびに学術講演会, Japanese, 独立行政法人国立病院機構 九州がんセンター 消化管外科, 福岡, Japan, Domestic conference高齢者に対する食道切除後の腸瘻チューブ留置による栄養介入の重要性Oral presentation
- 第74回日本気管食道科学会総会ならびに学術講演会, Japanese, 独立行政法人国立病院機構 九州がんセンター 消化管外科, 福岡, Japan, Domestic conferenceリンパ節郭清個数からみるMinimally invasive esophagectomyにおける上縦隔リンパ節郭清の重要性Oral presentation
- 第26回腹腔鏡内視鏡合同手術研究会, Japanese, 神戸大学 食道胃腸外科・神戸大学 国際がん医療・研究センター 消化器内科, 神戸, Japan, Domestic conference十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同⼿術における結腸間膜尾側からの腹腔鏡アプローチの有⽤性の検討Oral presentation
- IASGO-CME Advanced Post-Graduate Course in Kobe 2023, English, Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Graduate School of Medicine, Kobe University, Kobe, Japan, International conferenceClinical Significance of SUVmax on FDG-PET to Predict Treatment Response and Outcomes in Patients with Rectal Cancer Undergoing NACRTPoster presentation
- IASGO-CME Advanced Post-Graduate Course in Kobe 2023, English, Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Graduate School of Medicine, Kobe University, Kobe, Japan, International conferenceThe advantage of geriatric nutritional risk index as a prognostic indicator for elderly patients with early gastric cancer after noncurative endoscopic resectionPoster presentation
- The 3rd International Congress of the Asian Oncology Society (AOS2023), English, Department of Urology, Keio University School of Medicin, Yokohama, Japan, International conferenceThe significance of geriatric nutritional risk index as a prognostic factor for early gastric cancer in elderly patients after non-curative endoscopic resectionOral presentation
- The 3rd International Congress of the Asian Oncology Society (AOS2023), English, Department of Urology, Keio University School of Medicin, Yokohama, Japan, International conferenceAlbumin and derived neutrophil-to-lymphocyte ratio is a novel prognostic factor for patients with esophageal squamous cell carcinomaOral presentation
- 第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conference下部直腸癌に対するTaTMEの有用性とラーニングカーブPublic symposium
- 第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conferenceリンパ節転移比率からみるMinimally invasive esophagectomyにおける上縦隔リンパ節郭清の重要性Public symposium
- 第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conference当院におけるロボット支援下結腸切除術の導入 10例の経験Public symposium
- The Korea International Gastric Cancer Week 2023 (KINGCA WEEK 2023), English, The Korean Gastric Cancer Association, Seoul, Korea, Republic of, International conferenceThe advantage of geriatric nutritional risk index as a prognostic indictor for elderly patients with early gastric cancer after non-curative endoscopic resectionOral presentation
- The Korea International Gastric Cancer Week 2023 (KINGCA WEEK 2023), English, The Korean Gastric Cancer Association, Seoul, Korea, Republic of, International conferenceEfficacy of 18F-fluoro-2-deoxyglucose positron emission tomography as a predictor of treatment response to neoadjuvant chemotherapy for gastric cancerOral presentation
- 第33回日本サイトメトリー学会学術集会, Japanese, 杏林大学大学院医学研究科 共同研究施設フロ−サイトメトリ−部門, Web, Japan, Domestic conference深層学習に基づくイメージサイトメトリーによる直腸癌の新規予後因子の探索Poster presentation
- 第99回大腸癌研究会学術集会, Japanese, 関西労災病院 外科, 尼崎, Japan, Domestic conference下部直腸癌に対するTaTMEの有用性とラーニングカーブOral presentation
- 第66回関西胸部外科学会学術集会, Japanese, JCHO大阪病院, 大阪, Japan, Domestic conference高齢者食道癌患者に対する胸腔鏡下食道切除術Others
- 第66回関西胸部外科学会学術集会, Japanese, JCHO大阪病院, 大阪, Japan, Domestic conference進行食道癌に対するロボット支援下食道切除Public symposium
- 18th ISDE World Congress for Esophageal Diseases, English, International Society for Diseases of the Esophagus, Web, Japan, International conferenceRoutine Placement of Feeding Jejunostomy Tube During Esophagectomy Increases Postoperative Complications and Does Not Improve Postoperative MalnutritionOral presentation
- 第72回日本気管食道科学会総会ならびに学術講演会, Japanese, 大分大学呼吸器・乳腺外科学講座, web開催, Japan, Domestic conferenceレチノイン酸レセプターγはヒトiPS細胞から食道上皮への分化誘導を促進するPublic symposium
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conference胸部食道癌術後にsevereな体重減少を認める症例は予後不良であり、周術期に短期的な経腸栄養を行っても改善しないPoster presentation
- 7th FACO Academic Conference, English, Chinese Society of Clinical Oncology, shanghai, China, International conferenceWhen should esophagectomy be performed to non-curative superficial esophageal cancer after endoscopic resection?Poster presentation
- 第30回日本消化器癌発生学会総会, Japanese, 一般社団法人 日本消化器癌発生学会, 横浜, Japan, Domestic conference胸部食道癌に対し予防的頸部リンパ節郭清は省略可能かPublic symposium
- 第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conference内視鏡治療後非治癒切除症例に対する食道切除術の意義と適応Public symposium
- 第28回消化器疾患病態治療研究会, Japanese, 愛知医科大学 消化管内科, 名古屋, Japan, Domestic conference胃管癌に対する低侵襲治療Others
- 日本消化器外科学会, Japanese85歳以上の高齢者胃癌手術症例に対する治療成績の検討Public symposium
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conference胸部食道癌に対し予防的頸部リンパ節郭清は全例に必要か;予防的頸部郭清省略の検討Others
- 神戸消化器外科懇話会分科会, Japanese, 株式会社大塚製薬工場/イーエヌ大塚製薬株式会社, 神戸, Japan, Domestic conference胸部食道癌手術において経腸栄養tubeは前例に必要か?Oral presentation
- 第28回日本癌病態治療研究会, Japanese, 埼玉医科大学総合医療センター 消化管・一般外科/ゲノム診療科, 川越, Japan, Domestic conference胸部食道癌に対し予防的頸部リンパ節郭清は全例に必要かPublic symposium
- 第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conferenceAll-trans-レチノイン酸はヒトiPS細胞から食道上皮への分化誘導を促進するPoster presentation
- 第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conference食道切除再建術における経腸栄養tube留置の意義Poster presentation
- 第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conferenceロボット支援下食道切除術の導入と初期治療成績Poster presentation
- Korean Society of Endoscopic & Laparoscopic Surgeons, EnglishRoutine placement of feeding jejunostomy tube during thoracoscopic esophagectomy increases postoperative complications and does not improve postoperative malnutritionPoster presentation
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conference胸部食道癌手術において経腸栄養tube は全例に必要か?Poster presentation
- 第2回日本サルコーマ治療研究学会学術集会, Japanese, 公益財団法人がん研究会有明病院 総合腫瘍科, 東京, Japan, Domestic conferenceリプログラミング因子を用いた人工骨肉腫幹細胞株の樹立Poster presentation
- JDDW2018(第26回日本消化器関連学会週間), Japanese, 一般社団法人 日本消化器関連学会機構, 神戸, Japan, Domestic conference内視鏡治療後非治癒切除症例に対する食道切除術の適応Others
- ISDE world Congress for Esophageal Disease, EnglishA comparison of the clinical outcomes of esophagectomy and chemoradiotherapy after noncurative endoscopic submucosal dissection for esophageal squamous cell carcinomaOral presentation
- The international society for Diseases of the Esophagus (ISDE), English, International Society for Diseases of the Esophagus, Vienna, Austria, International conferenceComparison of the clinical outcomes of esophagectomy and chemoradiotherapy after noncurative endoscopic submucosal dissection for esophageal squamous cell carcinomaOral presentation
- 第73回日本消化器外科学会総会, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Japan, Domestic conference胸部食道癌手術において経腸栄養tube留置は省略できるか?Poster presentation
- 第72回日本食道学会学術集会, Japanese, 特定非営利活動法人 日本食道学会, 宇都宮, Japan, Domestic conference胸部食道癌手術において経腸栄養tubeは全例に必要か?Poster presentation
- 第118回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 東京, Japan, Domestic conference胸腔鏡下食道切除術に対する3D内視鏡の導入と治療成績Others
- 第118回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 東京, Japan, Domestic conference食道癌内視鏡的粘膜下層剥離術後非治療切除症例に対する追加治療例の検討Others
- 第55回日本癌治療学会学術総会, Japanese, 兵庫医科大学外科, 横浜, Japan, Domestic conference内視鏡的粘膜下層剥離術後非治癒切除症例に対する食道切除の意義とその役割Poster presentation
- 第30回近畿内視鏡外科研究会, Japanese, 京都大学 医学部 消化管外科, 大阪, Japan, Domestic conference腹腔鏡下食道亜全摘術を施行した食道炎症性腫瘤の1例Oral presentation
- 第200回近畿外科学会, Japanese, 近畿外科学会, 京都, Japan, Domestic conference炎症性食道腫瘤の1例Oral presentation
- 第60回関西胸部外科学会学術集会, Japanese, 兵庫医科大学 心臓血管外科, 大阪, Japan, Domestic conference縫合不全に対し食道ステントが有効であったイマチニブ投与後食道GISTの1例Others
- 第26回癌病態治療研究会, Japanese, 株式会社プランニングウィル, 横浜, Japan, Domestic conference内視鏡的粘膜下層剥離術後非治療切除症例に対する食道切除の意義とその役割Public symposium
- 第74回 阪神食道疾患検討会, Japanese, 阪神食道疾患検討会・日本化薬株式会社, 大阪, Japan, Domestic conference一般演題②Oral presentation
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Kobe University, Apr. 2019 - Mar. 2021Differentiation of human induced pluripotent stem cells into Barret esophageal epitheliumThe mechanisms regulating esophageal differentiation remain unclear. In particular, the details of the human esophagus itself have been poorly researched. In this decade, studies using human induced pluripotent stem cells (hiPSCs) have proven powerful tools for clarifying the developmental biology of various human organs. We established a novel stepwise protocol with transwell culture and an airliquid interface system for esophageal epithelial cell (EEC) differentiation from hiPSCs. We successfully generated stratified layers of cells expressing EEC marker genes that were positive for lugol staining. We then evaluated the effect of all-trans retinoic acid (ATRA), which is a retinoic acid receptor (RAR)α, RARβ and RARγ agonist, on the differentiation from the hiPSC-derived foregut. The enhancing effect of ATRA on EEC differentiation was clearly demonstrated. Finally, we revealed that RARγ activation promotes the differentiation of hiPSCs-derived foregut into EECs.