Research activity information

• Oct. 2013 日本口腔外科学会, ゴールドリボン賞, 学会での発表

  Kimoto Akira

  Japan society

• Zymosan-Treated SKG Mice: Assessing Effects of Systemic Inflammation on the Temporomandibular Joint.

  Kaito Uryu, Yasumasa Kakei, Sho Sendo, Ikuko Goto, Kengo Akashi, Keisuke Nishimum, Tatsuya Shirai, Junya Hirota, Daisuke Takeda, Manabu Shigeoka, Akira Kimoto, Takumi Hasegawa, Jun Saegusa, Masaya Akashi

  OBJECTIVES: The effects of systemic inflammation on the temporomandibular joint (TMJ) are poorly understood. This study aimed to establish a mouse model to study the effects of systemic inflammation on the TMJ. MATERIALS AND METHODS: SKG mice, a BALB/c strain with spontaneous onset of rheumatoid arthritis-like symptoms due to a spontaneous point mutation (W163C) in the gene encoding the SH2 domain of ZAP-70, were treated with zymosan (β-1,3-glucan). Synovitis, bone erosion, and cartilage damage in the TMJ were evaluated using established scores for animal models of inflammatory arthritis. Myeloperoxidase-positive areas and numbers of tartrate-resistant acid phosphatase (TRAP)-positive cells were compared between naive and zymosan-treated SKG mice. Correlations between TMJ inflammation scores and clinical scores for extremities were also assessed. RESULTS: There were significant differences in TMJ inflammation scores, including synovitis, bone erosion, and cartilage damage, between naive and high-dose zymosan-treated mice. There were significant differences in myeloperoxidase-positive areas and numbers of TRAP-positive cells between naive and zymosan-treated mice. There were significant correlations between TMJ inflammation scores and clinical scores for extremities. CONCLUSIONS: Systemic administration of zymosan efficiently induces TMJ inflammation in SKG mice. Zymosan-treated SKG mice offer a useful tool to investigate the effects of systemic inflammation on the TMJ.

  Dec. 2024, Oral diseases, English, International magazine

  Scientific journal


• ヒト下歯槽神経のバリア制御に関連する分子の解析

  平岡 佑二郎, 松村 恵実, 筧 康正, 武田 大介, 重岡 学, 木本 明, 長谷川 巧実, 明石 昌也

  (NPO)日本口腔科学会, Sep. 2024, 日本口腔科学会雑誌, 73(2) (2), 113 - 113, Japanese


• 当科における口腔癌癌患者の下顎の広範囲顎骨支持型装置に際し口腔前庭拡張術を要した11例

  高木 ひかる, 筧 康正, 白井 達也, 平岡 佑二郎, 有本 智美, 武田 大介, 木本 明, 長谷川 巧実, 明石 昌也

  (公社)日本顎顔面インプラント学会, Nov. 2023, Japanese Journal of Maxillo Facial Implants, 22(3) (3), 242 - 242, Japanese


• Photodynamic therapy with verteporfin accelerates apoptotic bleb formation in human ameloblastoma.

  Junya Yamashita, Akira Kimoto, Shun Teraoka, Yujiro Hiraoka, Daisuke Takeda, Yasumasa Kakei, Manabu Shigeoka, Takumi Hasegawa, Masaya Akashi

  OBJECTIVE: Although benign, ameloblastoma is a locally aggressive lesion in some patients and the development of additional treatments is needed. Verteporfin (VP) is a photosensitizer exhibiting considerable photocytotoxicity in various tumor cells. We aimed to investigate the effects of verteporfin photodynamic therapy (VP PDT) on ameloblastoma. METHODS: Eighteen patients who underwent surgery for ameloblastoma were randomly selected. We performed an immunohistochemical assessment to investigate the expression of low-density lipoprotein receptor (LDLR) and Yes-associated protein (YAP), targets of VP, in human ameloblastoma tissues and cultured human ameloblastoma cell line (HAM1). The effect of VP PDT on cell proliferation and apoptosis in HAM1 was analyzed. RESULTS: The expression of LDLR and YAP were detected in human ameloblastoma tissues and HAM1. LDLR expression was significantly higher in patients who had previously undergone surgery than in patients who were receiving it for the first time. The cytotoxic effect of the combination of low-concentration VP administration and laser irradiation was comparable to high-concentration VP administration with and without laser irradiation. The addition of laser irradiation to VP administration significantly accelerated apoptotic bleb formation compared with VP administration alone. CONCLUSION: VP PDT has the potential to become an additional treatment for large-sized ameloblastoma.

  Oct. 2023, Oral diseases, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Novel Imaging Technique for Analyzing Condylar Movement During Mastication in Patients With Jaw Deformities: Four-Dimensional Computed Tomography.

  Akira Kimoto, Junya Yamashita, Hiroaki Ohori, Noriyuki Negi, Toshinori Sekitani, Hiroki Komori, Atsushi Shioyasono, Chizu Tateishi, Takumi Hasegawa, Masaya Akashi

  OBJECTIVE: This study aimed to reveal characteristic condylar movements in patients with jaw deformities. STUDY DESIGN: Thirty patients with jaw deformities before surgery were enrolled and instructed to chew a cookie during 4-dimensional computed tomography (4DCT). The distance between the most anterior and posterior positions of the bilateral condyles on 4DCT images was measured and compared among patients with different skeletal classes. Correlations between the condylar protrusion and cephalometric values were also determined. RESULTS: The distances of condylar protrusion during mastication were significantly greater in the skeletal class II group than in the skeletal class III group (P=0.0002). Significant correlations were found between the distances of condylar protrusion during mastication and the sella-nasion-B point angle (r=-0.442, P=0.015), A point-nasion-B point angle (r=0.516, P=0.004), sella-nasion plane to ramus plane angle (r=0.464, P=0.01), sella-nasion plane to occlusal plane angle (r=0.367, P=0.047), and condylion-gonion length (r=-0.366, P=0.048). CONCLUSION: Motion analysis with 4DCT images revealed that condylar movement in patients with retrognathism was larger than in patients with mandibular prognathism. Skeletal structure was therefore correlated with condylar movement during mastication.

  Jul. 2023, The Journal of craniofacial surgery, English, International magazine

  Scientific journal


• 経皮的炭酸ガスペーストによるラット筋損傷モデルにおける瘢痕化防止と筋再生促進効果

  廣田 純也, 長谷川 巧実, 伊賀 利香, 八谷 奈苗, 黒澤 泉, 武田 大介, 筧 康正, 木本 明, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2023, 日本口腔科学会雑誌, 72(2) (2), 166 - 166, Japanese


• Expression of JCAD and EGFR in Perineurial Cell-Cell Junctions of Human Inferior Alveolar Nerve.

  Yujiro Hiraoka, Megumi Matsumura, Yasumasa Kakei, Daisuke Takeda, Manabu Shigeoka, Akira Kimoto, Takumi Hasegawa, Masaya Akashi

  Although perineurium has an important role in maintenance of the blood-nerve barrier, understanding of perineurial cell-cell junctions is insufficient. The aim of this study was to analyze the expression of junctional cadherin 5 associated (JCAD) and epidermal growth factor receptor (EGFR) in the perineurium of the human inferior alveolar nerve (IAN) and investigate their roles in perineurial cell-cell junctions using cultured human perineurial cells (HPNCs). In human IAN, JCAD was strongly expressed in endoneurial microvessels. JCAD and EGFR were expressed at various intensities in the perineurium. In HPNCs, JCAD was clearly expressed at cell-cell junctions. EGFR inhibitor AG1478 treatment changed cell morphology and the ratio of JCAD-positive cell-cell contacts of HPNCs. Therefore, JCAD and EGFR may have a role in the regulation of perineurial cell-cell junctions.

  Jun. 2023, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 71(6) (6), 221554231182193 - 221554231182193, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Efficacy and Long-Term Safety of Ibuprofen Gargle for Oral Lichen Planus: A Study Protocol of Randomized Crossover and Long-Term Extension Trials

  Yumi Kitahiro, Takeshi Ioroi, Yasumasa Kakei, Junya Yamashita, Akira Kimoto, Takumi Hasegawa, Asami Morioka, Kazuhiro Yamamoto, Masaya Akashi, Ikuko Yano

  Oral lichen planus (OLP) is a type of chronic and refractory stomatitis characterized by abnormal keratinization, which is often painful. There is no consensus regarding treatment options for OLP, particularly in the presence of pain. The current study protocol focuses on the short-term efficacy and long-term safety of an ibuprofen gargle for pain management in patients with OLP. Patients (n = 24) with painful OLP will be enrolled. During a crossover study period, patients in the ibuprofen–placebo (IP) group will receive an ibuprofen gargle (0.6%) on day 1, a placebo gargle on day 2, and an ibuprofen gargle on days 3–5 at least once daily. Patients in the placebo–ibuprofen (PI) group will receive a placebo gargle on day 1, an ibuprofen gargle on day 2, and an ibuprofen gargle on days 3–5 at least once daily. The primary endpoint of the crossover study period is the change in pain level as measured by a visual analogue scale score from before gargle administration to 5 min after gargle administration on days 1 and 2. The primary endpoint of the long-term extension study is assessment of long-term safety. The results of this study may support existing evidence regarding the effectiveness of ibuprofen rinses in treating OLP.

  MDPI AG, Jan. 2023, Methods and Protocols, 6(1) (1), 7 - 7

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 当科における口腔癌患者の広範囲顎骨支持型装置の成功率に関する後ろ向き観察研究

  早瀬 悠夏, 長谷川 巧実, 白井 達也, 平岡 佑二郎, 有本 智美, 武田 大介, 筧 康正, 木本 明, 明石 昌也

  (公社)日本顎顔面インプラント学会, Nov. 2022, Japanese Journal of Maxillo Facial Implants, 21(3) (3), 237 - 237, Japanese


• 口腔癌術後の再建組織より採取した分層植皮により顎堤形成術を施行した1例

  重永 一輝, 有本 智美, 武田 大介, 木本 明, 長谷川 巧実, 明石 昌也

  (公社)日本顎顔面インプラント学会, Nov. 2021, Japanese Journal of Maxillo Facial Implants, 20(3) (3), 189 - 189, Japanese


• Time to Recurrence Associated With Poor Prognosis in Japanese Oral Squamous Cell Carcinoma Patients

  Takumi Hasegawa, Erina Kobayashi, Rika Amano, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akira Kimoto, Akiko Sakakibara, Masaya Akashi

  Feb. 2021, JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, 21(3) (3), 856 - 864, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 舌下神経麻痺を契機に発見された前立腺癌脳転移の1例

  佐々木 亜紀, 木本 明, 八谷 奈苗, 村上 明希, 明石 昌也

  (NPO)日本口腔科学会, Sep. 2020, 日本口腔科学会雑誌, 69(3) (3), 245 - 245, Japanese


• 当科で歯科介入を行った高用量骨吸収抑制薬使用患者におけるMRONJ発症とリスク因子についての検討

  廣田 純也, 長谷川 巧実, 武田 大介, 筧 康正, 楠元 順哉, 榊原 晶子, 木本 明, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2020, 日本口腔科学会雑誌, 69(2) (2), 153 - 153, Japanese


• Neutrophil-lymphocyte ratio associated with poor prognosis in oral cancer: a retrospective study.

  Takumi Hasegawa, Tomoya Iga, Daisuke Takeda, Rika Amano, Izumi Saito, Yasumasa Kakei, Junya Kusumoto, Akira Kimoto, Akiko Sakakibara, Masaya Akashi

  BACKGROUND: Prognostic biomarkers provide essential information about a patient's overall outcome. However, existing biomarkers are limited in terms of either sample collection, such as requiring tissue specimens, or the process, such as prolonged time for analysis. In view of the need for convenient and non-invasive prognostic biomarkers for oral cancer, we aimed to investigate the prognostic values of neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio in patient survival. We also aimed to explore the associations of these ratios with the clinicopathologic characteristics of Japanese oral squamous cell carcinoma patients. METHODS: This study was a non-randomized retrospective cohort study in a tertiary referral center. We included 433 patients (246 men, 187 women) who underwent radical surgery for oral cancers between January 2001 and December 2013. We evaluated various risk factors for poor prognosis including neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio with univariate and multivariate analyses. The disease-specific survival and overall survival rates of patients were compared among the factors and biomarkers. RESULTS: In multivariable Cox proportional hazards analysis, high neutrophil-to-lymphocyte ratio (hazard ratio 2.87, 95% confidence interval 1.59-5.19, P <  0.001), moderately or poorly differentiated histology (hazard ratio 2.37, 95% confidence interval 1.32-4.25, P <  0.001), and extranodal extension (hazard ratio 1.95, 95% confidence interval 1.13-3.35, P = 0.016) were independent predictors of disease-specific survival. High neutrophil-to-lymphocyte ratio (hazard ratio 2.30, 95% confidence interval 1.42-3.72, P <  0.001), moderately or poorly differentiated (hazard ratio 1.72, 95% confidence interval 1.07-2.76, P = 0.025), and extranodal extension (hazard ratio 1.79, 95% confidence interval 1.13-2.84, P = 0.013) were independent predictors of overall survival. CONCLUSIONS: Neutrophil-to-lymphocyte ratio might be a potential independent prognostic factor in Japanese oral squamous cell carcinoma patients.

  Jun. 2020, BMC cancer, 20(1) (1), 568 - 568, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effects of preoperative dental examination and oral hygiene instruction on surgical site infection after hepatectomy: a retrospective study.

  Takumi Hasegawa, Daisuke Takeda, Motofumi Tanaka, Rika Amano, Izumi Saito, Yasumasa Kakei, Akira Kimoto, Takumi Fukumoto, Masaya Akashi

  PURPOSE: This study retrospectively investigated relationships among risk factors and post-hepatectomy surgical site infection (SSI) and other complications in patients who underwent hepatectomy for hepatocellular carcinoma (HCC). METHODS: We included 334 patients who underwent hepatectomies for liver cancers between January 2011 and December 2015 in this study. We evaluated risk factors for SSI and other post-hepatectomy complication, including demographic factors, preoperative factors, and preoperative intervention including oral management, perioperative factors, and length of hospital stay, with univariate and multivariate analyses. The oral management intervention included self-care instructions, extraction of infected teeth, removal of dental plaques and calculus (scaling), professional mechanical teeth cleaning, removal of tongue coating, and cleaning of dentures. SSI was defined in accordance with the guideline issued by the Centers for Disease Control and Prevention; it included purulent discharge from any incision or organ space within 30 days postoperatively, with or without microbiological evidence. Complications of grade II or greater, according to the Clavien-Dindo classification, were regarded as postoperative complications. RESULTS: We found bacterial infection of ascites (Odds ratio (OR) = 13.72), lack of preoperative oral management intervention (OR = 10.17), and severe liver fibrosis (OR = 2.76) to be associated with SSI and severe liver fibrosis (OR = 2.28), hypoalbuminemia (OR = 2.02), blood transfusion (OR = 1.86), and longer operation time (OR = 1.80) to be associated with postoperative complications. CONCLUSIONS: Preoperative oral management may reduce the risk of SSI in patients with HCC who undergo hepatectomy.

  May 2020, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(2) (2), 653 - 659, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 口腔癌に対するレーザー照射とその影響

  佐々木 崇良, 木本 明, 八谷 奈苗, 山下 淳也, 重岡 学, 明石 昌也

  (一社)日本レーザー歯学会, May 2020, 日本レーザー歯学会誌, 30(1) (1), 22 - 22, Japanese


• 【「歯科用レーザーの現在」】軟組織に対する歯科用レーザーの活用

  木本 明, 明石 昌也, 古森 孝英

  (一社)日本歯科理工学会, Sep. 2019, 日本歯科理工学会誌, 38(3) (3), 149 - 152, Japanese


• 歯科、口腔外科領域における進歩と課題 口腔がんに対するレーザー治療の応用 早期表在性舌がんに対するレーザー治療

  木本 明, 明石 昌也

  (NPO)日本レーザー医学会, Sep. 2019, 日本レーザー医学会誌, 40(3) (3), 265 - 265, Japanese


• Exploring a Novel Screening Method for Patients with Oral Squamous Cell Carcinoma: A plasma Metabolomics Analysis.

  Yui Enomoto, Akira Kimoto, Hiroaki Suzuki, Shin Nishiumi, Masaru Yoshida, Takahide Komori

  AIM: This study aimed to explore novel metabolite biomarker candidates for screening oral squamous cell carcinoma (OSCC). PATIENTS & METHODS: We collected plasma samples from 48 patients with OSCC and 29 with an oral disease and conducted a plasma metabolomics analysis of patients with OSCC using gas chromatography mass spectrometry. Then, we used the cross-validation procedure to ensure the accuracy of biomarker candidates. RESULTS: We selected four biomarker candidates against OSCC. Their sensitivity was more than 90%, and the AUC was over 0.9 according to the receiver operating characteristic curve analysis. CONCLUSIONS: The findings of this study suggest four potential metabolites as biomarkers for OSCC screening.

  Sep. 2018, The Kobe journal of medical sciences, 64(1) (1), E26-E35 - E35, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Elucidating the masticatory function and oral quality of life according to the range of mandibulectomy

  Michinori Maeda, Marina Hirose, Keinoshin Wada, Megumi Kishimoto, Masaya Akashi, Akira Kimoto, Takahide Komori, Yasuyuki Shibuya

  Elsevier Ltd, May 2018, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 30(3) (3), 220 - 224, English

  [Refereed]

  Scientific journal


• 金属アレルギーを伴う骨格性下顎前突患者に対し外科的矯正治療を行った1例

  塩屋園 敦, 立石 千鶴, 長谷川 巧実, 木本 明, 鈴木 泰明, 古土井 春吾, 古森 孝英, 神戸大学医学部附属病院歯科口腔外科矯正歯科診療班

  (NPO)日本顎変形症学会, May 2018, 日本顎変形症学会雑誌, 28(2) (2), 181 - 181, Japanese

  [Refereed]


• Simple Technique for Reducing the Buccal Fat Pad During Mandibular Orthognathic Surgery

  Kawase-KogaY, ShibataK, Kimoto Akira, WatanabeM, ChikazuD

  Sagittal split ramus osteotomy and intraoral vertical ramus osteotomy are commonly performed for the correction of jaw deformities. However, during mandibular orthognathic surgeries such as sagittal split ramus osteotomy and intraoral vertical ramus osteotomy , the authors sometimes encounter exposure of the buccal fat pad (BFP), which decreases the surgical field. The exposed BFP makes it difficult to perform these operations, may result in unexpected complications, and may increase the operation time. Therefore, the authors herein describe a simple, safe, and convenient technique for reducing the volume of the exposed BFP during mandibular orthognathic surgery using an electric knife in the coagulation mode.

  Feb. 2018, J Craniofac Surg, 29(4) (4), e404-e405, English, International magazine

  [Refereed]

  Scientific journal


• Usefulness of Early Plate Removal in Patients With Occlusal Discrepancies After Sagittal Split Ramus Osteotomy

  Kawase-KogaY, FujiiY, IkehataM, IkehataN, KonoM, Kimoto Akira, WatanabeM, ChikazuD

  The aim of this study was to evaluate the effects of early removal of fixed plates in patients with occlusal discrepancies after sagittal split ramus osteotomy (SSRO) with a focus on the positional relationship of the temporomandibular joint (TMJ). Sagittal split ramus osteotomy with/without Le Fort I osteotomy was performed on 98 patients with mandibular prognathism. Of these 98 patients, 15 with occlusal discrepancies and/or TMJ symptoms underwent early plate removal after SSRO. Finally, 12 consecutive patients were evaluated in this study: 7 underwent bilateral SSRO, 1 underwent unilateral SSRO, and 4 underwent bilateral SSRO with maxillary advancement. The axiolateral TMJ Schuller method was used to evaluate the TMJ position. The authors measured 3 spaces (anterior, superior, and posterior joint spaces) between the condyle and glenoid fossa in the sagittal plane. The anterior and superior joint spaces were significantly larger immediately after the operation than before the operation. After early plate removal, these spaces significantly decreased in size. The posterior joint space increased, but with no significant difference. Three months after SSRO, the size of each of the 3 spaces was closely related to its preoperative size. In conclusion, these results suggest that early removal of fixed plates is 1 treatment option for postoperative occlusal discrepancies after SSRO.

  Jan. 2018, J Craniofac Surg, 29(4) (4), 900 - 903, English, International magazine

  [Refereed]

  Scientific journal


• A Retrospective Evaluation of Partial Glossectomy for Early Tongue Cancer Using a Carbon Dioxide Laser

  Akira Kimoto, Hiroaki Suzuki, Junya Yamashita, Junichiro Takeuchi, Kousuke Matsumoto, Yui Enomoto, Takahide Komori

  Sep. 2017, PHOTOMEDICINE AND LASER SURGERY, 35(9) (9), 479 - 483, English

  [Refereed]

  Scientific journal


• Postradiotherapy Dental Implant Insertion Into Bone Grafts Harvested From Nonirradiated Tissue: Case Reports

  Kimoto Akira, ShibuyaY, KobayashiM, AkashiM, HasegawaT, SuzukiH, Komori Takahide

  Oct. 2016, Implant Dent, 25(5) (5), 715 - 9, English

  [Refereed]

  Scientific journal


• Concordance between clinical and histopathological diagnoses of oral lichen planus

  Yui Enomoto, Hiroaki Suzuki, Akira Kimoto, Tomoko Asai, Junichiro Takeuchi, Kousuke Matsumoto, Takahide Komori

  Elsevier Ltd, Sep. 2016, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 28(5) (5), 381 - 384, English

  [Refereed]

  Scientific journal


• 当科における埋伏智歯抜歯後神経系合併症に対する治療法の現状

  平岡 佑二郎, 明石 昌也, 松本 耕祐, 榊原 晶子, 木本 明, 長谷川 巧実, 鈴木 泰明, 南川 勉, 古土井 春吾, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2016, 日本口腔科学会雑誌, 65(2) (2), 176 - 177, Japanese


• 【最近の歯科におけるレーザーの応用】 口腔外科領域におけるレーザーの応用

  Komori Takahide, 榎本由依, 北山美登里, 小守紗也華, 松本耕祐, 木本明, 竹内純一郎, Suzuki Yasuaki

  Lasers are widely used in the oral and maxillofacial region surgeries. The CO₂ laser has been used in the treatment of diseases that occur in soft tissue because of its excellent incision and hemostatic abilities, and good results have been obtained. The Nd:YAG and KTP lasers have an affinity for pigmented tissues and penetrate soft tissues deeply. Using these characteristics, vascular malformations (hemangiomas) can be treated by photocoagulation with these lasers. In this paper, current status of oral and maxillofacial laser surgery is reported with some case presentations.

  Japan Society for Laser Surgery and Medicine, Apr. 2016, 日本レーザー医学会誌, 37(1号) (1号), 52 - 57, Japanese

  [Refereed]

  Scientific journal


• 口腔扁平苔癬に対する炭酸ガスレーザー蒸散療法の臨床評価に関する前向き研究

  松本耕祐, 榎本由依, 小野真嵩, 小守紗也華, 北山美登里, Kimoto Akira, Suzuki Yasuaki, Komori Takahide

  Dec. 2015, 日本レーザー歯学会誌, 26(3号) (3号), 124 - 129, Japanese

  [Refereed]

  Scientific journal


• 口腔白板症の臨床診断と病理組織診断の一致性についての検討 安全な口腔白板症のレーザー治療の実現に向けて

  榎本由依, Suzuki Yasuaki, 重岡學, 北山美登里, 松本耕祐, Kimoto Akira, 竹内純一郎, Komori Takahide

  Dec. 2015, 日本レーザー歯学会誌, 26(3号) (3号), 120 - 123, Japanese

  [Refereed]

  Scientific journal


• 口腔白板症の臨床診断と病理組織診断の一致性についての検討 -安全な口腔白板症のレーザー治療の実現に向けて-

  榎本由依, SUZUKI HIROAKI, 浅井知子, SHIGEOKA MANABU, 北山美登里, 松本耕祐, KIMOTO AKIRA, 竹内純一郎, KOMORI TAKAHIDE

  Dec. 2015, 日本レーザー歯学会誌, 26(3) (3), 120 - 3, Japanese

  [Refereed]

  Scientific journal


• 下顎臼歯部歯槽堤の頬側傾斜形態を考慮してサンドウィッチグラフトを応用した1例

  山下淳也, Kimoto Akira, Suzuki Yasuaki, Komori Takahide

  Nov. 2015, Japanese Journal of Maxillo Facial Implants, 14(3号) (3号), 193, Japanese

  Research society


• CT Evaluation of Morphology of Transferred Fibula for Implant Placement in Reconstructed Mandible

  Akashi Masaya, ShibuyaY, WanifuchiS, KusumotoJ, SakakibaraA, Kimoto Akira, Hasegawa Takumi, Suzuki Yasuaki, Hashikawa Kazunobu, Komori Takahide

  Oct. 2015, Implant Dent, 24(5) (5), 541 - 6, English

  [Refereed]

  Scientific journal


• 大理石骨病患者に対し矯正治療を行った1例

  北山美登里, 岡本奈那, 西村玲美, Kimoto Akira, Komori Takahide

  Sep. 2015, 障害者歯科, 36(3号) (3号), 423, Japanese

  Research society


• 口腔扁平苔癬に対する炭酸ガスレーザー蒸散療法の臨床評価に関する前向き研究(会議録)

  小野真嵩, 松本耕祐, 山下淳也, 小守紗也華, 榎本由依, 北山美登里, Kimoto Akira, Suzuki Yasuaki, Komori Takahide

  Aug. 2015, 日本レーザー歯学会誌, 26(2号) (2号), 90, Japanese

  Research society


• CO2レーザーによる舌早期癌に対する舌部分切除術に関する検討

  山下淳也, Kimoto Akira, 榎本由依, 松本耕祐, 小野真嵩, 筧康正, Suzuki Yasuaki, Komori Takahide

  (一社)日本レーザー歯学会, Aug. 2015, 日本レーザー歯学会誌, 26(2) (2), 89 - 90, Japanese

  Research society


• Clinical investigation of carbon dioxide laser treatment for lingual leukoplakia

  Kousuke Matsumoto, Hiroaki Suzuki, Tomoko Asai, Reina Wakabayashi, Yui Enomoto, Midori Kitayama, Manabu Shigeoka, Akira Kimoto, Junichiro Takeuchi, Hirokazu Yutori, Takahide Komori

  Elsevier Ltd, Jul. 2015, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 27(4) (4), 493 - 497, English

  [Refereed]

  Scientific journal


• Clinical investigation of carbon dioxide laser treatment for lingual leukoplakia

  Matsumoto K, SUZUKI HIROAKI, Asai T, Wakabayashi R, Enomoto Y, Kitayama M, SHIGEOKA MANABU, KIMOTO AKIRA, Takeuchi J, Yutori H, KOMORI TAKAHIDE

  Jul. 2015, J Oral Maxillofac Surg Med Pathol, 44(7) (7), 929 - 35, English

  [Refereed]

  Scientific journal


• 口腔白板症の臨床診断と病理組織診断の一致性および治療法についての検討

  榎本由依, Suzuki Yasuaki, 北山美登里, 重岡学, 松本耕祐, Kimoto Akira, 浅井知子, 竹内純一郎, Komori Takahide

  Apr. 2015, 日本レーザー歯学会誌, 26(1号) (1号), 56, Japanese

  Research society


• Clinical study of 19 cases resulting in dental implant removal

  Hiroaki Suzuki, Daiki Takahashi, Kenji Matsuo, Akira Kimoto, Kousuke Matsumoto, Takumi Hasegawa, Masaya Akashi, Takahide Komori

  Kobe University School of Medicine, 2015, Kobe Journal of Medical Sciences, 61(4) (4), E102 - E108, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Clinical investigation of carbon dioxide laser treatment for lingual leukoplakia

  MatsumotoK, Suzuki Yasuaki, AsaiT, WakabayashiR, EnomotoY, KitayamaM, ShigeokaM, Kimoto Akira, TakeuchiJ, YutoriH, Komori Takahide

  2015, Int J Oral Maxillofac Surg, 44(7) (7), 929 - 935, English

  [Refereed]

  Scientific journal


• 電気メス、レーザー等を用いた手術に関連するインシデントについて

  Suzuki Yasuaki, 筧 康正, 安岡 大介, 榎本 由依, 北山 美登里, Kimoto Akira, 松本 耕祐, 浅井 知子, 村田 真穂, Komori Takahide

  (一社)日本レーザー歯学会, Dec. 2014, 日本レーザー歯学会誌, 25(3) (3), 136 - 139, Japanese

  [Refereed]

  Scientific journal


• 著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った1例

  榎本 由依, 鈴木 泰明, 木本 明, 長谷川 巧実, 明石 昌也, 浅井 知子, 竹内 純一郎, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2014, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 144 - 144, Japanese


• 当科におけるインプラント242例907本埋入に関する臨床的検討

  川畑 真哉, 長谷川 巧実, 今井 佑輔, 木本 明, 明石 昌也, 鈴木 泰明, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2014, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 160 - 160, Japanese


• 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価

  明石 昌也, 渋谷 恭之, 鰐渕 聡, 木本 明, 長谷川 巧実, 鈴木 泰明, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2014, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 166 - 166, Japanese


• 口蓋に発生した嚢胞腺癌の1例

  高田 直樹, Shibuya Yasuyuki, Hasegawa Takumi, Kimoto Akira, 鈴木 泰明, Komori Takahide

  Cystadenocarcinoma is an uncommon salivary gland tumor that occurs in the palate. We report a rare case of cystadenocarcinoma arising in the palate. A 80-year-old man visited a certain hospital because of a painless swelling in the palate. A biopsy was performed, and adenocarcinoma was diagnosed histopathologically. He was therefore referred to our hospital to receive treatment for adenocarcinoma. He had a painless swelling, measuring 25 × 15 mm, in the left side of the palate. Computed tomography showed no evidence of cervical metastasis. Partial maxillectomy was performed, and the final histopathological diagnosis was cystadenocarcinoma. There was no evidence of recurrence or metastasis 20 months after the operation.

  Japanese Society of Oral and Maxillofacial Surgeons, Oct. 2014, 日本口腔外科学会雑誌, 60(10号) (10号), 561 - 565, Japanese

  [Refereed]

  Scientific journal


• 口腔癌再建術後の頸部感染評価目的でのCTの有用性

  明石 昌也, 古土井 春吾, 南川 勉, 木本 明, 榊原 晶子, 長谷川 巧実, 後藤 育子, 渋谷 恭之, 古森 孝英

  (NPO)日本口腔科学会, Sep. 2014, 日本口腔科学会雑誌, 63(4) (4), 381 - 381, Japanese


• レーザー治療後の経過観察中に悪性化を認めた口腔白板症3例の検討

  榎本由依, SUZUKI HIROAKI, 浅井知子, SHIGEOKA MANABU, 松本耕祐, KIMOTO AKIRA, 竹内純一郎, KOMORI TAKAHIDE

  Apr. 2014, 日本レーザー歯学会誌, 25(1) (1), 8 - 13, Japanese

  [Refereed]

  Scientific journal


• Clinical study of implant treatment for diabetic patients

  Enomoto Y, Suzuki Yasuaki, Kakei Y, Matsumoto K, Kimoto Akira, Komori Takahide

  2014, Oral Science in Japan, 49 - 50, English

  [Refereed]

  Scientific journal


• The long-term effects of red light-emitting diode irradiation on the proliferation and differentiation of osteoblast-like MC3T3-E1 cells

  Tomoko Asai, Hiroaki Suzuki, Midori Kitayama, Kousuke Matsumoto, Akira Kimoto, Manabu Shigeoka, Takahide Komori

  Kobe University School of Medicine, 2014, Kobe Journal of Medical Sciences, 60(1) (1), E12 - E18, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 舌に発生した平滑筋腫の1例

  木本 明, 渋谷 恭之, 浅野 真衣, 高田 直樹, 竹内 佑香, Komori Takahide

  Leiomyoma is a benign tumor of smooth muscle origin, and usually arises in the uterus, alimentary tract, and skin. Since the first report by Blanc in 1884, most reported leiomyomas have been angioleiomyomas. In the present report, we describe a rare type of leiomyoma arising in the tongue of a 25-year-old woman. The tumor was an 18 × 7 mm, well-demarcated, and slow growing mass located in the right margin of the tongue. The entire lesion was excised, and the pathological diagnosis was solid leiomyoma. The patient has been followed up for 1 year 2 months after surgery, without any evidence of recurrence.

  Japanese Society of Oral and Maxillofacial Surgeons, Aug. 2013, 日本口腔外科学会雑誌, 59(8号) (8号), 522 - 526, Japanese

  [Refereed]

  Scientific journal


• 上下顎歯肉に発生したメトトレキサート関連リンパ球増殖性疾患の1例

  木本 明, 鈴木 泰明, Furudoi Shungo, Takeuchi Junichi, 浅井 知子, Komori Takahide

  Abstract: Patients with rheumatoid arthritis often receive methotrexate (MTX). Recently, it has been shown that MTX can cause B cell lymphoma, non-Hodgkins lymphoma. B cell lymphoma caused by MTX is referred to as a methotrexate-associated lymphoproliferative disorder (MTX-LPD) and is recognized by the World Health Organization and included among immunodeficiency-associated LPD. We describe a rare case of MTX-LPD with osteonecrosis of the jaw of maxilla and mandible in which spontaneous complete remission was achieved.

  Japanese Society of Oral and Maxillofacial Surgeons, Mar. 2013, 日本口腔外科学会雑誌, 59(3号) (3号), 197 - 201, Japanese

  [Refereed]

  Scientific journal


• 小児の下顎骨に発生したEwing肉腫の1例

  浅井 知子, 南川 勉, 木本 明, 鈴木 泰明, 渋谷 恭之, Komori Takahide

  A case of Ewings sarcoma of the mandible in a young child is presented. A 12-year-old boy was referred to our hospital because of swelling of the cheek, which he noticed 2 months previously. Clinical examination revealed diffuse swelling of the cheek, and a fistula of the gingiva. CT examination revealed a sun-ray apiculated image. MR showed a contract-enhancing lesion in the left mandibular angle. FDG-PET and Ga-scintigraphy revealed no metastasis. Based on the results of histopathological analysis, Ewings sarcoma was diagnosed. The patient received combined chemotherapy, surgery, and radiotherapy. The patient has shown no evidence of recurrence or metastasis for 24 months.

  Japanese Society of Oral and Maxillofacial Surgeons, Feb. 2013, 日本口腔外科学会雑誌, 59(2号) (2号), 88 - 92, Japanese

  [Refereed]

  Scientific journal


• A novel gas chromatography mass spectrometry-based serum screening method for Oral squamous cell carcinoma

  Kimoto, A., Nishiumi, S., Kobayashi, T., Terashima, Y., Suzuki, H., Takeuchi, J., Azuma, T., Komori, T., Yoshida, M.

  2013, Head and Neck Oncology, 5(4) (4), 40, English

  [Refereed]

  Scientific journal


• Plexiform perineurioma of the lip: a case report and review of literature.

  Fumi Kawakami, Takanori Hirose, Akira Kimoto, Takahide Komori, Tomoo Itoh

  We describe a plexiform perineurioma, which is an extremely rare variant of soft tissue perineurioma. A 43-year-old Japanese man presented with a painless, well-demarcated, elastic, soft tumor measuring 2.0 × 1.9 cm on the upper lip that had persisted for three years. Microscopically, a plexiform tumor composed of minimally atypical spindle cells with wavy nuclei was located in the lamina propria of the oral mucosa. Tumor cells were concentrically arranged around small vessels and aligned in parallel with delicate collagen fibers on a fibromyxoid background in the hypocellular area. Tumor cells were immunohistochemically positive for EMA, GLUT-1, claudin-1, and CD34 and negative for S-100 protein. The histopathological and immunohistochemical profiles of the excised tumor indicated a diagnosis of plexiform perineurioma. The patient has remained free of recurrence for sixteen months. Intraoral soft tissue perineurioma is rare and two of the four reported plexiform perineuriomas, including that described herein, notably involved the intraoral area. According to previous reports, plexiform perineuriomas largely develop in middle-aged women without a history of type 1 or type 2 neurofibromatosis. The clinical courses of all reported plexiform perineuriomas have been benign.

  Oct. 2012, Pathology international, 62(10) (10), 704 - 8, English, International magazine

  [Refereed]

  Scientific journal


• 上顎歯肉癌術後に骨転移を疑った胸鎖関節炎の1例

  今井 佑輔, 南川 勉, 木本 明, 明石 昌也, 古森 孝英

  (NPO)日本口腔科学会, Jan. 2012, 日本口腔科学会雑誌, 61(1) (1), 128 - 129, Japanese


• Application of polyglycolic acid sheet and fibrin glue spray for partial glossectomy : Comparison with artificial dermis

  TAKEUCHI Junichiro, UMEDA Masahiro, MURATA Maho, KAKEI Yasumasa, KIMOTO Akira, SUZUKI Hiroaki, SHIGETA Takashi, RI Shinsho, KOMORI Takahide

  日本口腔外科学会, Jul. 2011, Japanese journal of oral and maxillofacial surgery, 57(7) (7), 394 - 400, Japanese


• 口腔白板症におけるCO2レーザー切除時の開放創に対するネオベールシートおよびボルヒールスプレーの使用経験

  竹内 純一郎, 鈴木 泰明, 木本 明, 松本 耕祐, 村田 真穂, 古森 孝英

  (一社)日本レーザー歯学会, Apr. 2010, 日本レーザー歯学会誌, 21(1) (1), 45 - 45, Japanese


• Nd:YAGレーザーを用いた深部凝固療法により処置を行った口腔血管腫の16例

  重岡 学, 鈴木 泰明, 梶 真人, 木本 明, 服部 真季, 松本 耕祐, 村田 真穂, 古森 孝英

  (一社)日本レーザー歯学会, Aug. 2008, 日本レーザー歯学会誌, 19(2) (2), 90 - 90, Japanese


• 外側舌リンパ節転移を認めた口底癌の1例

  木本 明, 南川 勉, 小林 正樹, 服部 真季, 明石 昌也, 澁谷 恭之, 横尾 聡, 梅田 正博, 古森 孝英

  (公社)日本口腔外科学会, Jun. 2007, 日本口腔外科学会雑誌, 53(6) (6), 400 - 400, Japanese


• Ror2シグナルからみた口腔粘膜治癒過程におけるCO2レーザーの有用性の検討

  鈴木 泰明, 木本 明, 時岡 早苗, 村田 真穂, 服部 真季, 松本 耕祐, 梶 真人, 古森 孝英

  (一社)日本レーザー歯学会, Apr. 2007, 日本レーザー歯学会誌, 18(1) (1), 57 - 57, Japanese


• 口腔白板症のレーザー治療と培養粘膜を用いた再生医療

  服部 真季, 鈴木 泰明, 松本 耕祐, 木本 明, 梶 真人, 村田 真穂, 尾島 泰公, 時岡 早苗, 横尾 聡, 古森 孝英

  (NPO)日本レーザー医学会, Jan. 2007, 日本レーザー医学会誌, 27(4) (4), 359 - 359, Japanese

• Clinical analysis of the chronological change in bone mass following sinus floor elevation

  Suzuki Hiroaki, Matsumoto Kousuke, Enomoto Yui, Kakei Yasumasa, Kimoto Akira, Akashi Masaya, Komori Takahide

  Japanese Stomatological Society, 2015, Oral science in Japan, 79 - 82, English


• 【全身疾患と抜歯-最新の知識による適切な対応-】 喘息・アレルギー疾患を有する患者の抜歯

  Kimoto Akira, Komori Takahide

  Jan. 2015, 歯科医療, 29(1号) (1号), 30 - 37, Japanese

  [Invited]

  Introduction commerce magazine


• 【全身疾患と抜歯-最新の知識による適切な対応-】 全身疾患を有する患者の抜歯の際に注意すべき基本的事項

  Komori Takahide, Akashi Masaya, Suzuki Yasuaki, 榊原晶子, Kimoto Akira, Minamikawa Tsutomu, Hasegawa Takumi, Furudoi Shungo

  (株)第一歯科出版, Jan. 2015, 歯科医療, 29(1号) (1号), 4 - 10, Japanese

  [Invited]

  Introduction scientific journal


• Successive macroglossia after toxic epidermal necrolysis

  Suzuki Yasuaki, Shibuya Y, Enomoto Y, Kimoto Akira, Matsumoto K, Kakei Y, Komori Takahide

  Japanese Stomatological Society, 2014, Oral Science in Japan, 79 - 81, English

  Introduction scientific journal


• Clinical experience with the application of polyglycolic acid sheets and fibrin glue spray after resection of buccal mucosal lesions: A pilot study

  Kakei Y, Suzuki Yasuaki, Enomoto Y, Kimoto Akira, Matsumoto K, Takeuchi J, Komori Takahide

  Japanese Stomatological Society, 2014, Oral Science in Japan, 69 - 71, English

  Introduction scientific journal


• A case report of dental treatment of Shy-Drager syndrome

  KIMOTO AKIRA

  30 Sep. 2011, 障害者歯科, 32(3) (3), 429 - 429, Japanese

• 全身疾患と抜歯 -最新の知識による適切な対応- / 全身疾患と抜歯 -最新の知識による適切な対応-

  古森孝英, 明石昌也, 鈴木泰明, 榊原晶子, Kimoto Akira, 南川勉, 長谷川巧, 古土井春吾

  Others, 第一歯科出版, 2015, Japanese

  Scholarly book


• 新こんな患者さんが歯科に来たときは？全身疾患・口腔外科疾患に対する診療マニュアル / アナフィラキシーへの対応

  Kimoto Akira, 高橋佑豪

  Others, 第一歯科出版, 2014, Japanese

  General book

• 神戸大学病院歯科口腔外科における過去10年間のレーザー治療に対する臨床的検討

  香西慎一, KIMOTO AKIRA, 八谷奈苗, 山下淳也, 松尾健司, 榎本由依, 松本耕祐, 北山美登里, SHIGEOKA MANABU, SUZUKI HIROAKI, KOMORI TAKAHIDE

  第30回記念日本レーザー歯学会学術大会, Oct. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• 三次元実態模型を用いた手術シミュレーションー当科における最近の使用経験

  鰐渕 聡, Akashi Masaya, Hashikawa Kazunobu, 筧 康正, 松本 耕祐, Kimoto Akira, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, 古森 孝英

  第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 下顎臼歯部頬側傾斜形態を考慮してサンドウィッチグラフト法を応用した1例

  山下 淳也, Kimoto Akira, Suzuki Yasuaki, 古森 孝英

  第60回日本口腔外科学会総会．, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• Search for oral cancer relates biomarker by metabolomics of plasma in tumor-bearing nude mice．

  榎本 由依, Kimoto Akira, 鰐渕 聡, Suzuki Yasuaki, 古森 孝英

  第60回日本口腔外科学会総会．, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• Nd：YAGレーザー光凝固療法を複数回行った口腔領域血管奇形5症例の臨床的検討

  小野 真嵩, 松本 耕祐, 山下 淳也, 小守 紗也華, 榎本 由衣, 北山 美登里, Kimoto Akira, Suzuki Yasuaki, 古森 孝英

  第60回日本口腔外科学会総会．, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• Evaluating the changes in the amount of bone augmentation after sinus lift using panoramic radiography: Comparison evaluations based on CT images．

  松尾 健司, Suzuki Yasuaki, 松本 耕祐, Kimoto Akira, Hasegawa Takumi, Akashi Masaya, 竹内 順一郎, 古森 孝英

  第60回日本口腔外科学会総会．, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• Effects of Red Light-Emitting Diode Irradiation on the Proliferation and Differentiation of Preosteoblastic MC3T3-E1 Cells

  SUZUKI HIROAKI, Asai T, Enomoto Y, Kitayama M, KIMOTO AKIRA, SHIGEOKA MANABU, Chikazu D, KOMORI TAKAHIDE

  22nd International conference on oral and maxillofacial surgery, Oct. 2015, Japanese, Mellbourne, Australia, International conference

  Poster presentation


• "EFFECTS OF RED LIGHT-EMITTING DIODE IRRADIATION ON THE PROLIFERATION AND DIFFERENTIATION OF PREOSTEOBLASTIC MC3T3-E1 CELLS,

  Suzuki Yasuaki, Asai T, Enomoto Y, Kitayama M, Matsumoto Kensuke, Kimoto Akira, Shigeoka M, Chikazu D, Komori Takahide

  22nd International conference on oral and maxilofacial surgery,, Oct. 2015, Japanese, メルボルン, オーストラリア, International conference

  Oral presentation


• 女児の下顎枝に生じたランゲルハンス細胞組織球症の1例

  定兼 啓倫, Kimoto Akira, 榎本 由依, 小林 正樹, Minamikawa Tsutomu, 古森 孝英

  第46回日本口腔外科学会近畿支部学術集会．, Jun. 2015, Japanese, 日本口腔外科学会, 神戸, Domestic conference

  Oral presentation


• 口腔扁平苔癬に対する炭酸ガスレーザー蒸散療法の臨床評価に関する前向き研究

  小野 真嵩, 松本 耕祐, 山下 淳也, 小守 紗也華, 榎本 由衣, 北山 美登里, Kimoto Akira, Suzuki Yasuaki, 古森 孝英

  日本レーザー歯学会, Jun. 2015, Japanese, 日本レーザー歯学会, 北海道, Domestic conference

  Oral presentation


• CO2レーザーによる舌早期癌に対する舌部分切除に関する検討

  山下 淳也, Kimoto Akira, 榎本 由依, 松本 耕祐, 小野 真嵩, 筧 康正, Suzuki Yasuaki, 古森 孝英

  日本レーザー歯学会, Jun. 2015, Japanese, 日本レーザー歯学会, 北海道, Domestic conference

  Oral presentation


• 口腔白板症の臨床診断の一致性および治療法についての検討

  榎本由依, SUZUKI HIROAKI, 北山美登里, SHIGEOKA MANABU, 松本耕祐, KIMOTO AKIRA, 浅井知子, 竹内純一郎, KOMORI TAKAHIDE

  第26回日本レーザー歯学会総会・学術大会, Dec. 2014, Japanese, 東京, Domestic conference

  Poster presentation


• 口腔白板症の臨床診断の一致性および治療法についての検討

  榎本 由依, Suzuki Yasuaki, 北山 美登里, 重岡 学, 松本 耕祐, Kimoto Akira, Asai Tomoko, 竹内 純一郎, Komori Takahide

  第26回日本レーザー歯学会, Dec. 2014, Japanese, 日本レーザー歯学会, 東京, Domestic conference

  Poster presentation


• 当科におけるインプラント242例907本埋入に関する臨床的検討

  川畑 真哉, Hasegawa Takumi, 今井 佑輔, Kimoto Akira, Akashi Masaya, Suzuki Yasuaki, Komori Takahide

  第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference

  Oral presentation


• 著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った症例

  榎本 由依, Suzuki Yasuaki, Kimoto Akira, Hasegawa Takumi, Akashi Masaya, 竹内 純一郎, Komori Takahide

  第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference

  Oral presentation


• 上顎洞底挙上術後の上顎洞粘膜肥厚の経時的変化に関する検討

  松本 耕祐, Suzuki Yasuaki, 筧 康正, Kimoto Akira, 李 進彰, Shibuya Yasuyuki, Komori Takahide

  第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference

  Oral presentation


• 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価

  Akashi Masaya, Shibuya Yasuyuki, 鰐渕 聡, Kimoto Akira, Hasegawa Takumi, Suzuki Yasuaki, Komori Takahide

  第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference

  Oral presentation


• 当科における上顎洞底挙上術後の骨量変化の臨床的検討

  寺岡 駿, Suzuki Yasuaki, 筧 康正, 石田 優, Kimoto Akira, Hasegawa Takumi, Asai Tomoko, 竹内 純一郎, Shibuya Yasuyuki, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 口腔癌再建術後の頸部感染評価目的でのCTの有用性

  Akashi Masaya, Furudoi Shungo, Minamikawa Tsutomu, Kimoto Akira, Sakakibara Akiko, Hasegawa Takumi, 後藤 育子, Shibuya Yasuyuki, Komori Takahide

  第68回日本口腔科学会学術総会, May 2014, Japanese, 日本口腔科学会, 東京, Domestic conference

  Oral presentation


• レーザー治療後を含め経過観察中に癌化を認めた口腔白板症例の検討

  榎本由依, SUZUKI HIROAKI, 浅井知子, 安岡大介, 浅井雅敏, SHIGEOKA MANABU, 松本耕祐, KIMOTO AKIRA, 竹内純一郎, KOMORI TAKAHIDE

  第25回日本レーザー歯学会総会・学術大会, Sep. 2013, Japanese, 東京, Domestic conference

  Oral presentation


• CO2レーザーにより切除された舌組織の病理組織学的診断に及ぼす障害の検討

  松本耕祐, SUZUKI HIROAKI, SHIGEOKA MANABU, KIMOTO AKIRA, 竹内純一郎, KOMORI TAKAHIDE

  第21回日本レーザー歯学会学術集会, Nov. 2009, Japanese, Domestic conference

  Oral presentation


• Nd:YAGレーザーを用いた深部凝固療法により処置を行った口腔血管腫の16例

  SHIGEOKA MANABU, SUZUKI HIROAKI, 梶真人, KIMOTO AKIRA, 服部真季, 松本耕祐, 村田真穂, KOMORI TAKAHIDE

  第19回日本レーザー歯学会学術集会, Nov. 2007, Japanese, Domestic conference

  Oral presentation

• 好中球に着眼したシェーグレン症候群の新規病理分類提案と治療薬探索

  後藤 育子, 西村 啓佑, 重岡 学, 木本 明, 明石 昌也, 明石 健吾, 筧 康正

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2023 - 31 Mar. 2026


• 顎骨壊死に対する腐骨分離促進療法の探索

  明石 昌也, 重岡 学, 有本 智美, 木本 明, 長谷川 巧実, 筧 康正

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2023 - 31 Mar. 2026


• 統合オミックス解析による口腔がん制御機構の解明と創薬標的の網羅的探索

  木本 明, 明石 昌也, 榎本 由依

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2021 - 31 Mar. 2024

  口腔がんの大部分は扁平上皮癌であり、標準的治療は手術とされている。また、補助療法として放射線治療、化学療法が併用されることが多いが、進行がんに対しては予後が悪く、制御が可能であった場合でも患者自身のQOLを著しく低下させる。そのため、根治治療を目的としながらも、可能な限り機能を温存することも口腔がんにおいては重要である。現在、口腔がんに対する化学療法は、シスプラチン(CDDP)や5-FU、ドセタキセルが使用されている。しかし、進行がんを制御するまでは至っておらず、副作用も多い。本研究では、統合オミックス解析を行い、口腔がんに特異的な代謝経路を探索する。また、それに関わる代謝酵素のうち、がんの増殖の制御に関わるものを導き出し、その阻害剤の効果を検討することで、将来的な口腔がんの新たな治療薬の開発をめざす。 今年度は、まずヒト由来口腔がん細胞株（OSC-19、HSC-3）のガスクロマトグラフィー質量分析を実施した。また、口腔がん患者の血漿メタボローム解析を実施し、得られたデータを統計ソフトを用いて多変量解析することで、口腔がん患者に特異的な代謝物の変動を探索している。次に、ヒト由来口腔がん細胞株と血漿メタボローム解析の結果と比較することで、特に著明な変化を示す代謝経路の探索を開始している。今後は、これらに加え、口腔がん生体材料のメタボローム解析を実施することで、さらに口腔がん特異的な代謝経路を絞っていく予定である。


• 血管・リンパ管新生に着眼した歯性感染症－顎骨骨髄炎移行メカニズム解明と治療法探索

  明石 昌也, 木本 明, 長谷川 巧実, 筧 康正

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2019 - 31 Mar. 2023

  骨粗鬆症などに対し用いられる骨吸収抑制薬や、口腔癌に対し施行される放射線照射等の医療行為が素因となる顎骨骨髄炎は、近年患者数の増加に伴い顎口腔外科領域において最も新たな治療法開発が期待される難治性疾患の一つである。本研究の目的は、近年感染の進展にも関与していることが明らかとなりつつある血管・リンパ管新生をターゲットとし、歯性感染症－顎骨骨髄炎移行メカニズムを解明することである。 研究の端緒として、まず血管新生のマーカーとなりうる分子の検討を行なった。近年動脈硬化や高血圧、腫瘍の増大における病的な状態における血管新生に関与している可能性が示唆されている血管内皮細胞間接着複合体構成分子に注目した。この分子についてはマウスやヒト培養細胞を用いた研究はこれまでに行われてきたが、ヒトの組織内での発現や局在部位を確認した報告は稀少であった。昨年度の研究結果より、この分子がヒトの組織内でも特に非炎症部位の血管に比べ炎症部位の微小血管等に発現が強く、病的な血管のマーカーとなり得る可能性が示唆され、この結果を英文査読付き学術誌に投稿し、採択された。次に、放射線性骨髄炎で顎骨内を感染がどのように侵入部から拡散し、特に顎関節方向へと拡散するのかを調査した。放射線性顎骨壊死では放射線性の影響と思われるダメージが皮質骨のすぐ内側で強く認められ、同部を介して感染が顎関節方向へ進展する可能性が考えられた。こうした下顎骨内をどのように感染が進展するかを手術検体を用いて詳細に調査した研究は希少であり、当該年度この研究成果を英文査読付き学術誌に投稿し、採択された。


• 血漿メタボローム解析による口腔がん術後再発・転移診断法の確立

  木本 明

  学術研究助成基金助成金／若手研究(B), Apr. 2017 - Mar. 2020, Principal investigator

  Competitive research funding


• メタボローム解析を用いたARONJに対する新規LED治療の開発

  鈴木 泰明

  学術研究助成基金助成金／基盤研究(C), Apr. 2017 - Mar. 2020

  Competitive research funding


• LED光を用いた頭頸部癌化学放射線療法に伴う口腔粘膜炎の新規治療法の開発

  古森 孝英

  学術研究助成基金助成金／挑戦的萌芽研究, Apr. 2015 - Mar. 2018

  Competitive research funding


• 網羅的メタボローム解析によるインプラントリスクファクター検出法の確立

  鈴木 泰明

  学術研究助成基金助成金／基盤研究(C), Apr. 2014 - Mar. 2017

  Competitive research funding


• 質量分析計を用いた口腔がんスクリーニングの実用化

  木本 明

  学術研究助成基金助成金／若手研究(B), Apr. 2014 - Mar. 2017, Principal investigator

  Competitive research funding


• メタボローム解析による口腔がん早期発見スクリーニング法の開発

  古森 孝英

  学術研究助成基金助成金／基盤研究(C), Apr. 2012 - Mar. 2015

  Competitive research funding