Research activity information

• Mar. 2016 日本循環器学会, Circ J Award, 優秀論文賞

  Mori K, Ishida T, Yasuda T, Hasokawa M, Monguchi T, Sasaki M, Kondo K, Nakajima H, Shinohara M, Shinke T, Irino Y, Toh R, Nishimura K, Hirata K.


• Jul. 2013 日本動脈硬化学会, 第5回JAT賞, 原著論文

  SunL, Ishida Tatsuro, OkadaT, YasudaT, HaraT, TohR, ShinoharaM, YamashitaT, RikitakeY, HirataK

  Japan society


• Sep. 2004 成人血管病研究振興財団, Young Investigator Okamoto Award, Japan Vascular Disease Research Foundation, ＨＤＬ代謝と動脈硬化の成因における血管内皮リパーゼの作用

  ISHIDA Tatsuro

• ACLY Promotes Cardiac Fibrosis via the Regulation of DNL and Histone Acetylation

  Naoya Kuwahara, Manabu Nagao, Masakazu Shinohara, Kenta Kaneshiro, Takuo Emoto, Takeshi Yoshida, Terunobu Fukuda, Makoto Nishimori, Seimi Satomi-Kobayashi, Hiromasa Otake, Ken-Ichi Hirata, Tatsuro Ishida, Ryuji Toh

  BACKGROUND: ATP citrate lyase (ACLY) is a key enzyme in de novo lipogenesis that generates acetyl-CoA from citrate. Although fatty acids are required for energy production and biomass synthesis in the heart, the regulatory mechanisms of ACLY-mediated de novo lipogenesis in pathological cardiac fibroblasts remain unknown. The aim of this study was to investigate the biological role of ACLY in cardiac remodeling. METHODS: Adeno-associated virus serotype 9-mediated shRNA targeting Acly was intravenously injected into C57BL/6J male mice. The mice were subsequently continuously infused with a mixture of angiotensin II and phenylephrine. Cardiac phenotypes were evaluated via histological staining. Cell proliferation assays, stable isotope tracing with 13C-labeled glucose, and chromatin immunoprecipitation assays were performed using human cardiac fibroblasts. RESULTS: ACLY expression was upregulated in the heart sections of mice treated with angiotensin II/phenylephrine, in particular in fibrotic areas. Masson trichrome staining revealed that Acly gene silencing significantly reduced cardiac fibrosis in these mice. Both siRNA-mediated ACLY knockdown and pharmacological ACLY inhibition suppressed the proliferation and expression of fibrous proteins in cultured human cardiac fibroblasts stimulated with transforming growth factor-β. Mechanistically, ACLY inhibition reduced de novo lipogenesis, limiting the fatty acid supply essential for cellular growth and proliferation. It also decreased H3K9 and H3K27 acetylation, in addition to the presence of acetylated H3K9 and H3K27 at the promoter regions of fibrotic genes. CONCLUSIONS: Our findings demonstrate that ACLY plays an important role in maladaptive cardiac fibrosis. ACLY could be a novel therapeutic target to prevent the development of heart failure.

  Ovid Technologies (Wolters Kluwer Health), Mar. 2025, Hypertension

  Scientific journal


• Increased Red Cell Superoxide Dismutase Activity Is Associated with Cancer Risk: A Hidaka Cohort Study

  Shin-ichiro Tanaka, Yoshio Fujioka, Takeshi Tsujino, Tatsuro Ishida, Ken-ichi Hirata

  Nov. 2024, CANCER RESEARCH COMMUNICATIONS, 4(11) (11), 2868 - 2876, English

  Scientific journal


• Assessment of transthyretin instability in patients with wild-type transthyretin amyloid cardiomyopathy.

  Takuya Iino, Manabu Nagao, Hidekazu Tanaka, Sachiko Yoshikawa, Junko Asakura, Makoto Nishimori, Masakazu Shinohara, Amane Harada, Shunsuke Watanabe, Tatsuro Ishida, Ken-Ichi Hirata, Ryuji Toh

  Sep. 2024, Scientific reports, 14(1) (1), 20508 - 20508, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Overview of the 88th th Annual Scientific Meeting of the Japanese Circulation Society (JCS2024) ― The Future of Cardiology - Challenges in Overcoming Cardiovascular Disease ―

  Hidekazu Tanaka, Tatsuro Ishida, Takuo Emoto, Manabu Nagao, Yu Izawa, Terunobu Fukuda, Takayoshi Toba, Eriko Hisamatsu, Yu Taniguchi, Kimitake Imamura, Mitsuru Takami, Hiroyuki Kawamori, Hiromasa Otake, Koji Fukuzawa, Ryuji Toh, Seimi Satomi-Kobayashi, Tomoya Yamashita, Ken-ichi Hirata

  Sep. 2024, CIRCULATION JOURNAL, 88(9) (9), 1502 - 1508, English

  Scientific journal


• Overview of the 88^th Annual Scientific Meeting of the Japanese Circulation Society (JCS2024) ― The Future of Cardiology - Challenges in Overcoming Cardiovascular Disease

  Hidekazu Tanaka, Tatsuro Ishida, Takuo Emoto, Manabu Nagao, Yu Izawa, Terunobu Fukuda, Takayoshi Toba, Eriko Hisamatsu, Yu Taniguchi, Kimitake Imamura, Mitsuru Takami, Hiroyuki Kawamori, Hiromasa Otake, Koji Fukuzawa, Ryuji Toh, Seimi Satomi-Kobayashi, Tomoya Yamashita, Ken-ichi Hirata

  Sep. 2024, CIRCULATION JOURNAL, 88(9) (9), 1502 - 1508, English

  Scientific journal


• Impaired Cholesterol Uptake Capacity in Patients with Hypertriglyceridemia and Diabetes Mellitus.

  Yutaro Seto, Manabu Nagao, Takuya Iino, Amane Harada, Katsuhiro Murakami, Keiko Miwa, Masakazu Shinohara, Makoto Nishimori, Sachiko Yoshikawa, Junko Asakura, Tomoo Fujioka, Tatsuro Ishida, Ken-Ichi Hirata, Ryuji Toh

  Apr. 2024, The journal of applied laboratory medicine, 9(4) (4), 728 - 740, English, International magazine

  [Refereed]

  Scientific journal


• Stress-induced stenotic vascular remodeling via reduction of plasma omega-3 fatty acid metabolite 4-oxoDHA by noradrenaline.

  Makoto Nishimori, Naomi Hayasaka, Kazunori Otsui, Nobutaka Inoue, Junko Asakura, Manabu Nagao, Ryuji Toh, Tatsuro Ishida, Ken-Ichi Hirata, Tomoyuki Furuyashiki, Masakazu Shinohara

  Feb. 2024, Scientific reports, 14(1) (1), 4178 - 4178, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Are Omega-3 Fatty Acids A Magic Potion?

  Tatsuro Ishida

  2024, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 31(2) (2), 117 - 118, English


• Association Between Serum 3-Hydroxyisobutyric Acid and Prognosis in Patients With Chronic Heart Failure - An Analysis of the KUNIUMI Registry Chronic Cohort.

  Wataru Fujimoto, Manabu Nagao, Makoto Nishimori, Masakazu Shinohara, Makoto Takemoto, Koji Kuroda, Soichiro Yamashita, Junichi Imanishi, Masamichi Iwasaki, Takafumi Todoroki, Masanori Okuda, Hidekazu Tanaka, Tatsuro Ishida, Ryuji Toh, Ken-Ichi Hirata

  Dec. 2023, Circulation journal : official journal of the Japanese Circulation Society, 88(1) (1), 110 - 116, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Plasma cystine/methionine ratio is associated with left ventricular diastolic function in patients with heart disease.

  Junko Asakura, Manabu Nagao, Masakazu Shinohara, Makoto Nishimori, Sachiko Yoshikawa, Takuya Iino, Yutaro Seto, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-Ichi Hirata, Ryuji Toh

  Aug. 2023, Heart and vessels, 38(12) (12), 1422 - 1430, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Impact of High-Density Lipoprotein Function, Rather Than High-Density Lipoprotein Cholesterol Level, on Cardiovascular Disease Among Patients With Familial Hypercholesterolemia.

  Hayato Tada, Hirofumi Okada, Atsushi Nohara, Ryuji Toh, Amane Harada, Katsuhiro Murakami, Takuya Iino, Manabu Nagao, Tatsuro Ishida, Ken-Ichi Hirata, Masayuki Takamura, Masa-Aki Kawashiri

  May 2023, Circulation journal : official journal of the Japanese Circulation Society, 87(6) (6), 806 - 812, English, Domestic magazine

  Scientific journal


• Association of Serum Levels of Cholesterol Absorption and Synthesis Markers with the Presence of Cardiovascular Disease: The CACHE Study CVD Analysis.

  Shunsuke Katsuki, Tetsuya Matoba, Yusuke Akiyama, Hiroshi Yoshida, Kazuhiko Kotani, Hisako Fujii, Mariko Harada-Shiba, Yutaka Ishibashi, Tatsuro Ishida, Yasushi Ishigaki, Daijiro Kabata, Yasuki Kihara, Satoshi Kurisu, Daisaku Masuda, Kota Matsuki, Takeshi Matsumura, Kenta Mori, Tomoko Nakagami, Masamitsu Nakazato, Satsuki Taniuchi, Hiroaki Ueno, Shizuya Yamashita, Hisako Yoshida, Hiroyuki Tsutsui, Tetsuo Shoji

  Apr. 2023, Journal of atherosclerosis and thrombosis, 30(12) (12), 1766 - 1777, English, Domestic magazine

  Scientific journal


• Fully automated immunoassay for cholesterol uptake capacity to assess high-density lipoprotein function and cardiovascular disease risk.

  Katsuhiro Murakami, Amane Harada, Ryuji Toh, Takuya Kubo, Keiko Miwa, Jeeeun Kim, Maria Kiriyama, Takuya Iino, Youichi Nishikawa, Shin-Nosuke Uno, Kohei Akatsuchi, Manabu Nagao, Tatsuro Ishida, Ken-Ichi Hirata

  Feb. 2023, Scientific reports, 13(1) (1), 1899 - 1899, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Association between Familial Hypercholesterolemia and Serum Levels of Cholesterol Synthesis and Absorption Markers: The CACHE Study FH Analysis.

  Kota Matsuki, Mariko Harada-Shiba, Mika Hori, Masatsune Ogura, Yusuke Akiyama, Hisako Fujii, Yutaka Ishibashi, Tatsuro Ishida, Yasushi Ishigaki, Daijiro Kabata, Yasuki Kihara, Kazuhiko Kotani, Satoshi Kurisu, Daisaku Masuda, Tetsuya Matoba, Takeshi Matsumura, Kenta Mori, Tomoko Nakagami, Masamitsu Nakazato, Satsuki Taniuchi, Hiroaki Ueno, Shizuya Yamashita, Hiroshi Yoshida, Hisako Yoshida, Tetsuo Shoji

  Jan. 2023, Journal of atherosclerosis and thrombosis, 30(9) (9), 1152 - 1164, English, Domestic magazine

  Scientific journal


• Serum Values of Cholesterol Absorption and Synthesis Biomarkers in Japanese Healthy Subjects: The CACHE Study HEALTHY Analysis

  Yutaka Ishibashi, Hiroshi Yoshida, Kazuhiko Kotani, Yusuke Akiyama, Hisako Fujii, Mariko Harada-Shiba, Tatsuro Ishida, Yasushi Ishigaki, Daijiro Kabata, Yasuki Kihara, Satoshi Kurisu, Daisaku Masuda, Tetsuya Matoba, Kota Matsuki, Takeshi Matsumura, Kenta Mori, Tomoko Nakagami, Masamitsu Nakazato, Satsuki Taniuchi, Hiroaki Ueno, Shizuya Yamashita, Shozo Yano, Hisako Yoshida, Shoji Tetsuo

  2023, Journal of Atherosclerosis and Thrombosis, 30(10) (10), 1336 - 1349, English

  Scientific journal


• Relationship between Diabetes Mellitus and Serum Lathosterol and Campesterol Levels: The CACHE Study DM Analysis.

  Takeshi Matsumura, Yasushi Ishigaki, Tomoko Nakagami, Yusuke Akiyama, Yutaka Ishibashi, Tatsuro Ishida, Hisako Fujii, Mariko Harada-Shiba, Daijiro Kabata, Yasuki Kihara, Kazuhiko Kotani, Satoshi Kurisu, Daisaku Masuda, Tetsuya Matoba, Kota Matsuki, Kenta Mori, Masamitsu Nakazato, Satsuki Taniuchi, Hiroaki Ueno, Shizuya Yamashita, Hiroshi Yoshida, Hisako Yoshida, Tetsuo Shoji

  Sep. 2022, Journal of atherosclerosis and thrombosis, 30(7) (7), 735 - 753, English, Domestic magazine

  Scientific journal


• Inhibition of glutaminase 1-mediated glutaminolysis improves pathological cardiac remodeling.

  Sachiko Yoshikawa, Manabu Nagao, Ryuji Toh, Masakazu Shinohara, Takuya Iino, Yasuhiro Irino, Makoto Nishimori, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-Ichi Hirata

  May 2022, American journal of physiology. Heart and circulatory physiology, 322(5) (5), H749-H761 - H761, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Association of Kidney Function with Serum Levels of Cholesterol Absorption and Synthesis Markers: The CACHE Study CKD Analysis.

  Tetsuo Shoji, Yusuke Akiyama, Hisako Fujii, Mariko Harada-Shiba, Yutaka Ishibashi, Tatsuro Ishida, Yasushi Ishigaki, Daijiro Kabata, Yasuki Kihara, Kazuhiko Kotani, Satoshi Kurisu, Daisaku Masuda, Tetsuya Matoba, Kota Matsuki, Takeshi Matsumura, Kenta Mori, Tomoko Nakagami, Masamitsu Nakazato, Satsuki Taniuchi, Hiroaki Ueno, Shizuya Yamashita, Hisako Yoshida, Hiroshi Yoshida

  Mar. 2022, Journal of atherosclerosis and thrombosis, 29(12) (12), 1835 - 1848, English, Domestic magazine

  Scientific journal


• Association between urinary N-acetyl-β-glucosaminidase activity-urinary creatinine concentration ratio and risk of disability and all-cause mortality.

  Shin-Ichiro Tanaka, Yoshio Fujioka, Takeshi Tsujino, Tatsuro Ishida, Ken-Ichi Hirata

  2022, PloS one, 17(3) (3), e0265637, English, International magazine

  Scientific journal


• 古典的冠疾患リスク因子を有さない症例に対する虚血性心疾患スクリーニングにおけるアポリポタンパク質B-48濃度測定の有用性

  増田 大作, 山下 静也, 田中 克尚, 岡田 健志, 小関 正博, 西田 誠, 森 健太, 石田 達郎, 平田 健一

  (一社)日本動脈硬化学会, Oct. 2021, 日本動脈硬化学会総会プログラム・抄録集, 53回, 212 - 212, Japanese


• Effects of Elaidic Acid on HDL Cholesterol Uptake Capacity.

  Takuya Iino, Ryuji Toh, Manabu Nagao, Masakazu Shinohara, Amane Harada, Katsuhiro Murakami, Yasuhiro Irino, Makoto Nishimori, Sachiko Yoshikawa, Yutaro Seto, Tatsuro Ishida, Ken-Ichi Hirata

  Sep. 2021, Nutrients, 13(9) (9), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 動脈硬化リスクの至適管理に関する最前線 アポリポ蛋白B-48濃度は残存するCVリスクと薬の有効性を評価する有用なマーカーである(Front Lines of Optimal Management of Atherosclerosis Risks Apolipoprotein B-48 Concentration is a Useful Marker for Evaluating Residual CV Risk and the Effectiveness of Medication)

  Masuda Daisaku, Yamashita Shizuya, Tanaka Katsunao, Okada Takeshi, Koseki Masahiro, Nishida Makoto, Mori Kenta, Hirata Ken-ichi, Ishida Tatsuro

  (一社)日本循環器学会, Mar. 2021, 日本循環器学会学術集会抄録集, 85回, SY11 - 2, English


• Critical role of glutamine metabolism in cardiomyocytes under oxidative stress.

  Koichi Watanabe, Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Masakazu Shinohara, Takuya Iino, Sachiko Yoshikawa, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-Ichi Hirata

  Jan. 2021, Biochemical and biophysical research communications, 534, 687 - 693, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Fibronectin-containing High-Density Lipoprotein is Associated with Cancer Cell Adhesion and Proliferation.

  Eriko Hisamatsu, Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Takuya Iino, Tetsuya Hara, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-Ichi Hirata

  A large amount of evidence suggests that high-density lipoprotein (HDL) has anti-atherosclerotic properties. HDL-cholesterol (HDL-C) has also been widely used as a marker of cardiovascular disease. Recently, it was reported that plasma HDL-C levels are inversely correlated with cancer risk. However, the relationship between HDL and cancer pathophysiology remains unknown. Here, we sought to investigate the effect of HDL on cancer progression. First, we focused on fibronectin-an essential extracellular matrix glycoprotein-as an HDL-associated protein and found that only 7.4% of subjects in this study had fibronectin in HDL isolated from their plasma. The fibronectin-containing HDL (FN-HDL) increased the phosphorylation of focal adhesion kinase (FAK) in HeLa cells compared to HDL without fibronectin, further inducing the phosphorylation in a dose-dependent manner. Second, we found that fibronectin-treated HDL activated the phosphorylation of FAK, and its upstream effector blocked the phosphorylation induced by FN-HDL. Finally, we demonstrated that FN-HDL promoted cancer cell proliferation and adhesion compared to HDL without fibronectin. Our study showed the possible mechanism by which FN-HDL enhanced cancer cell proliferation and adhesion via the FAK signaling pathway. Further investigation of the roles of HDL components in tumorigenesis might provide novel insight into cancer pathophysiology.

  Aug. 2020, The Kobe journal of medical sciences, 66(1) (1), E40-E48, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 新規マウス静脈血栓塞栓症モデルの構築(Establishment of Novel Murine Venous Thromboembolism Model)

  Okano Mitsumasa, Hara Tetsuya, Nishimori Makoto, Nagao Manabu, Irino Yasuhiro, Kobayashi Seimi, Shinohara Masakazu, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  (一社)日本循環器学会, Jul. 2020, 日本循環器学会学術集会抄録集, 84回, PE64 - 5, English


• Adding Alirocumab to Rosuvastatin Helps Reduce the Vulnerability of Thin-Cap Fibroatheroma

  Yoichiro Sugizaki, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-ichi Yanaka, Hiroyuki Yamamoto, Akira Nagasawa, Hiroyuki Onishi, Ryo Takeshige, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Toshiro Shinke, Tatsuro Ishida, Ken-ichi Hirata

  Jun. 2020, JACC: Cardiovascular Imaging, 13(6) (6), 1452 - 1454, English

  Scientific journal


• In Vivo Imaging of Venous Thrombus and Pulmonary Embolism Using Novel Murine Venous Thromboembolism Model.

  Mitsumasa Okano, Tetsuya Hara, Makoto Nishimori, Yasuhiro Irino, Seimi Satomi-Kobayashi, Masakazu Shinohara, Ryuji Toh, Farouc A Jaffer, Tatsuro Ishida, Ken-Ichi Hirata

  Apr. 2020, JACC. Basic to translational science, 5(4) (4), 344 - 356, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Association of cholesterol uptake capacity, a novel indicator for HDL functionality, and coronary plaque properties: An optical coherence tomography-based observational study.

  Toshihiko Oshita, Ryuji Toh, Yuichiro Nagano, Koji Kuroda, Yoshinori Nagasawa, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Takuya Kubo, Takuya Iino, Manabu Nagao, Yasuhiro Irino, Tetsuya Hara, Masakazu Shinohara, Hiromasa Otake, Toshiro Shinke, Katsuyuki Nakajima, Tatsuro Ishida, Ken-Ichi Hirata

  Apr. 2020, Clinica chimica acta; international journal of clinical chemistry, 503, 136 - 144, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Novel Indicator for HDL Functionality.

  Yasuhiro Irino, Ryuji Toh, Tatsuro Ishida

  Nov. 2019, Journal of atherosclerosis and thrombosis, 26(11) (11), 945 - 946, English, Domestic magazine

  Link to Kobe Univ. Repository (Kernel)


• Serum elaidic acid concentration and risk of dementia: The Hisayama study.

  Honda T, Ohara T, Shinohara M, Hata J, Toh R, Yoshida D, Shibata M, Ishida T, Hirakawa Y, Irino Y, Sakata S, Uchida K, Kitazono T, Kanba S, Hirata KI, Ninomiya T

  Oct. 2019, Neurology, 93(22) (22), e2053-e2064 - E2064, English, International magazine

  [Refereed]

  Scientific journal


• Serum concentration of full-length- and carboxy-terminal fragments of endothelial lipase predicts future cardiovascular risks in patients with coronary artery disease.

  Nagao M, Miyashita K, Mori K, Irino Y, Toh R, Hara T, Hirata KI, Shinohara M, Nakajima K, Ishida T

  Jul. 2019, Journal of clinical lipidology, 13(5) (5), 839 - 846, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effect of Rosuvastatin and Eicosapentaenoic Acid on Neoatherosclerosis: The LINK-IT Trial.

  Kuroda K, Otake H, Shinohara M, Kuroda M, Tsuda S, Toba T, Nagano Y, Toh R, Ishida T, Shinke T, Hirata KI

  Jul. 2019, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 15(12) (12), e1099-e1106 - +, English, International magazine

  [Refereed]

  Scientific journal


• Impaired Cholesterol-Uptake Capacity of HDL Might Promote Target-Lesion Revascularization by Inducing Neoatherosclerosis After Stent Implantation.

  Yuichiro Nagano, Hiromasa Otake, Takayoshi Toba, Koji Kuroda, Yuto Shinkura, Natsuko Tahara, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Akira Nagasawa, Hiroyuki Onishi, Yoichiro Sugizaki, Ryo Takeshige, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Toshihiko Oshita, Yasuhiro Irino, Hiroyuki Kawamori, Tatsuro Ishida, Ryuji Toh, Toshiro Shinke, Ken-Ichi Hirata

  May 2019, Journal of the American Heart Association, 8(9) (9), e011975, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Establishment of Femoral Vein Ligation Model: a New DVT Imaging Model

  Tetsuya Hara, Mitsumasa Okano, Makoto Nishimori, Koichi Watanabe, Yasuhiro Irino, Seimi Kobayashi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata

  May 2019, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 39, English


• Identification of novel serum markers for the progression of coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia.

  Masashi Shiomi, Hiroaki Takeda, Yasuhiro Irino, Norie Kimura, Satoshi Yamada, Nobue Kuniyoshi, Akio Kikumori, Yu Koike, Tomonari Koike, Masaru Yoshida, Yoshihiro Izumi, Masakazu Shinohara, Takeshi Bamba, Tatsuro Ishida

  May 2019, Atherosclerosis, 284, 18 - 23, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Elevated Serum Elaidic Acid Predicts Risk of Repeat Revascularization After Percutaneous Coronary Intervention in Japan

  Oshita T, Toh Ryuji, Shinohara M, Mori K, Irino Y, Nagao M, Hara T, Otake H, Ishida T, Hirata Ken-ichi

  Mar. 2019, Circ J, 83(5) (5), 1032 - 1038, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Species differences in lipoprotein lipase and hepatic lipase activities: comparative studies of animal models of lifestyle-related diseases

  Kimura N, Kikumori A, Kawase D, Okano M, Fukamachi K, Ishida Tatsuro, Nakajima K, SHIOMI MASASHI

  Feb. 2019, Exp Anim, 68(3) (3), 267 - 275, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Enhancing Blockchain Traceability with DAG-based Tokens

  Hiroki Watanabe, Tatsuro Ishida, Shigenori Ohashi, Shigeru Fujimura, Atsushi Nakadaira, Kota Hidaka, Jay Kishigami

  2019, 2019 IEEE INTERNATIONAL CONFERENCE ON BLOCKCHAIN (BLOCKCHAIN 2019), 220 - 227, English

  International conference proceedings


• Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, vs. Cholesterol Efflux Capacity in Association With Coronary Plaque Lipid Burden.

  Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Kouichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Seimi Kobayashi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake, Tatsuro Ishida, Ken-ichi Hirata

  Nov. 2018, CIRCULATION, 138, English


• Establishment of Novel Deep Venous Thrombosis Model Suitable for In Vivo Imaging.

  Mitsumasa Okano, Tetsuya Hara, Makoto Nishimori, Koichi Watanabe, Toshihiko Oshita, Yasuhiro Irino, Seimi Kobayashi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata

  Nov. 2018, CIRCULATION, 138, English


• Reduction of 5-ipoxygenase Derived Docosahexaenoic Acid Metabolites Under Social Mental Stress: Their Function for Maintenance of Heme Oxygenase-1 Expression in Macrophage

  Makoto Nishimori, Masakazu Shinohara, Kouichi Watanabe, Mitsumasa Okano, Toshihiko Oshita, Kenta Mori, Tetsuya Hara, Yasuhiro Irino, Seimi Kobayashi, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata

  Nov. 2018, CIRCULATION, 138, English


• Impact of serum cholesterol esterification rates on the development of diabetes mellitus in a general population

  Tanaka SI, Fujioka Y, Tsujino T, Ishida T, Hirata Ken-ichi

  BACKGROUND: Lecithin:cholesterol acyltransferase (LCAT) plays an important role in cholesterol esterification in serum. Serum LCAT activity is elevated in patients with serum high triglyceride and low high-density lipoprotein-cholesterol (HDL-C) concentrations, both of which are related to metabolic syndrome and subsequent diabetes mellitus, referred to as lipotoxicity. We hypothesized that increased serum LCAT activity could predict future risk of diabetes mellitus in a general Japanese population. METHODS: We prospectively studied 1496 individuals aged 20-86 years without histories of diabetes mellitus at baseline. Serum lipid concentrations, glucose parameters, and LCAT activity measured as the serum cholesterol esterification rate, were evaluated. RESULTS: During 11 years of follow-up, 46 newly diagnosed patients with diabetes mellitus were reported. After adjustment for plasma glycosylated hemoglobin A1c (HbA1c) levels, the relative risks (RRs) for the development of diabetes mellitus were 5.45 [95% confidence interval (95% CI) 2.37-12.55; P <  0.001] for body-mass index, 0.22 (95% CI, 0.09-0.53; P = 0.001) for HDL-C, 4.81 (95% CI, 1.96-11.77; P = 0.001) for triglyceride, and 4.64 (95% CI, 1.89-11.41; P = 0.001) for LCAT activity. After adjustment for HbA1c, total cholesterol, triglyceride, HDL-C, phospholipid, and free fatty acid levels, the RR of LCAT activity for future risk of diabetes mellitus remained significant (RR, 4.93; 95% CI,1.32-18.41; P = 0.018). In this analysis, we found a significant association between LCAT activity and risk of diabetes mellitus in men but not in women. CONCLUSION: Increased serum cholesterol esterification rate is a potent predictor for future diabetes mellitus.

  Jul. 2018, Lipids Health Dis, 17(1) (1), 180 - 180, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Identification of Novel Lipid Markers for Coronary Atherosclerosis in WHHLMI Rabbits, an Animal Model of Familial Hypercholesterolemia

  Masashi Shiomi, Hiroaki Takeda, Yasuhiro Irino, Satoshi Yamada, Nobue Kuniyoshi, Yui Koike, Tomonari Koike, Yasuhiro Izumi, Masakazu Shinohara, Yakeshi Bamba, Tatsuro Ishida

  Elsevier BV, Jun. 2018, Atherosclerosis Supplements, 32, 67 - 68

  Scientific journal


• Progression of calcific aortic valve sclerosis in WHHLMI rabbits

  Tetsuya Hara, Norie Tsukada, Mitsumasa Okano, Tatsuro Ishida, Ken-ichi Hirata, Masashi Shiomi

  Elsevier Ireland Ltd, Jun. 2018, Atherosclerosis, 273, 8 - 14, English, International magazine

  [Refereed]

  Scientific journal


• 新規マウス血栓モデルによる赤血球凝集主体のDVT生体イメージング

  岡野光真, Hara Tetsuya, 渡部晃一, 尾下寿彦, 津田成康, 入野康宏, 小林成美, 篠原正和, 杜隆嗣, 石田達郎, 平田健一

  日本臨床分子医学会, Apr. 2018, 日本臨床分子医学会学術総会プログラム・抄録集 55回, 55回, 58 - 58, Japanese


• 再構成HDLのphospholipid組成はその抗炎症作用に影響する(Phospholipid Composition of Reconstitute High Density Lipoproteins Affects Their Anti-inflammatory Effects)

  岡野 光真, 入野 康宏, 篠原 正和, 田中 伸明, 尾下 寿彦, 津田 成康, 渡部 晃一, 森 健太, 原 哲也, 小林 成美, 杜 隆嗣, 石田 達郎, 平田 健一

  (一社)日本循環器学会, Mar. 2018, 日本循環器学会学術集会抄録集, 82回, PJ015 - 1, English


• 高血圧患者における高塩分食品・調味料の使用習慣に基づいた塩分摂取量簡易評価方法の検討

  脇田久美子, 三ヶ尻礼子, 田渕聡子, 山西美沙, 赤毛弘子, 玉田萌子, 西田ひかる, 中谷早希, 金谷沙紀, 森智子, 向山万為子, 中村美仁, 山本育子, 松田佳子, 高橋路子, 小川渉, Kobayashi Seimi, 石田達郎, 大瀬良知子, 栗原伸公

  Jan. 2018, 日本病態栄養学会誌, 21(Supple) (Supple), 125, Japanese

  Symposium


• Eicosapentaenoic acid-enriched high-density lipoproteins exhibit anti-atherogenic properties

  Nobuaki Tanaka, Yasuhiro Irino, Masakazu Shinohara, Shigeyasu Tsuda, Takeshige Mori, Manabu Nagao, Toshihiko Oshita, Kenta Mori, Tetsuya Hara, Ryuji Toh, Tatsuro Ishida, Ken-Ichi Hirata

  Japanese Circulation Society, 2018, Circulation Journal, 82(2) (2), 596 - 601, English, Domestic magazine

  [Refereed]

  Scientific journal


• Eicosapentaenoic acid-enriched high-density lipoproteins exhibit anti-atherogenic properties

  Nobuaki Tanaka, Yasuhiro Irino, Masakazu Shinohara, Shigeyasu Tsuda, Takeshige Mori, Manabu Nagao, Toshihiko Oshita, Kenta Mori, Tetsuya Hara, Ryuji Toh, Tatsuro Ishida, Ken-Ichi Hirata

  Japanese Circulation Society, 2018, Circulation Journal, 82(2) (2), 596 - 601, English

  [Refereed]

  Scientific journal


• An enzyme-linked immunosorbent assay for measuring GPIHBP1 levels in human plasma or serum

  MiyashitaK, FukamachiI, NagaoM, Ishida Tatsuro, KobayashiJ, MachidaT, NakajimaK, MurakamiM, PlougM, BeigneuxAP, YoungSG, NakajimaK

  Nov. 2017, J Clin Lipidol, 12(1) (1), 203 - 210, English, International magazine

  [Refereed]

  Scientific journal


• The impact of serum trans fatty acids concentration on plaque vulnerability in patients with coronary artery disease: Assessment via optical coherence tomography

  Yoshinori Nagasawa, Toshiro Shinke, Ryuji Toh, Tatsuro Ishida, Hiromasa Otake, Tomofumi Takaya, Daisuke Sugiyama, Takayosi Toba, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Natsuko Tahara, Yuto Shinkura, Kenzo Uzu, Daiji Kashiwagi, Koji Kuroda, Yuichiro Nagano, Hiroyuki Yamamoto, Kenichi Yanaka, Yoshiro Tsukiyama, Ken-ichi Hirata

  Oct. 2017, ATHEROSCLEROSIS, 265, 312 - 317, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Novel mechanism of regulation of the 5-lipoxygenase/leukotriene B-4 pathway by high-density lipoprotein in macrophages

  Shigeyasu Tsuda, Masakazu Shinohara, Toshihiko Oshita, Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Tetsuya Hara, Yasuhiro Irino, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata

  Oct. 2017, SCIENTIFIC REPORTS, 7(1) (1), 12989 - 12989, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Cholesterol Uptake Capacity: A New Measure of HDL Functionality for Coronary Risk Assessment.

  Amane Harada, Ryuji Toh, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Takuya Kubo, Yasuhiro Irino, Kenta Mori, Nobuaki Tanaka, Kunihiro Nishimura, Tatsuro Ishida, Ken-Ichi Hirata

  BACKGROUND: Recent studies have shown that the cholesterol efflux capacity of HDL is a better predictor of cardiovascular disease (CVD) than HDL cholesterol. However, the standard procedures used for measuring cholesterol efflux capacity involve radioisotope-labeled cholesterol and cultured macrophages. Thus, a simpler method to measure HDL functionality is needed for clinical application. METHODS: We established a cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which we named cholesterol "uptake capacity," using fluorescently labeled cholesterol and an anti-apolipoprotein A1 antibody. We quantified cholesterol uptake capacity of apolipoprotein B (apoB)-depleted serum samples from patients with coronary artery disease who had previously undergone revascularization. RESULTS: This assay system exhibited high reproducibility (CV <10%) and a short processing time (<6 h). The myeloperoxidase-mediated oxidation of apoB-depleted serum impaired cholesterol uptake capacity. Cholesterol uptake capacity correlated significantly with cholesterol efflux capacity (r2 = 0.47, n = 30). Furthermore, cholesterol uptake capacity correlated inversely with the requirement for revascularization because of recurrence of coronary lesions in patients with optimal control of LDL cholesterol (P < 0.01, n = 156). A multivariate analysis adjusted for traditional coronary risk factors showed that only cholesterol uptake capacity remained significant (odds ratio, 0.48; 95% CI, 0.29-0.80; P = 0.0048). CONCLUSIONS: Cholesterol uptake capacity assay evaluates the functionality of HDL in a sensitive and high-throughput manner without using radioisotope label and cells. This assay system could be used for the assessment of CVD risk in the clinical settings.

  Sep. 2017, The journal of applied laboratory medicine, 2(2) (2), 186 - 200, English, International magazine

  Scientific journal


• High-density lipoprotein protects cardiomyocytes from oxidative stress via the PI3K/mTOR signaling pathway

  Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Hideto Nakajima, Toshihiko Oshita, Shigeyasu Tsuda, Tetsuya Hara, Masakazu Shinohara, Tatsuro Ishida, Ken-ichi Hirata

  Sep. 2017, FEBS OPEN BIO, 7(9) (9), 1402 - 1409, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo

  Tetsuya Hara, Tomoko Monguchi, Noriko Iwamoto, Masaya Akashi, Kenta Mori, Toshihiko Oshita, Mitsumasa Okano, Ryuji Toll, Yasuhiro Irino, Masakazu Shinohara, Yui Yamashita, Go Shioi, Mikio Furuse, Tatsuro Ishida, Ken-ichi Hirata

  Sep. 2017, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 37(9) (9), 1667 - +, English, International magazine

  [Refereed]

  Scientific journal


• Excessive intake of trans fatty acid accelerates atherosclerosis through promoting inflammation and oxidative stress in a mouse model of hyperlipidemia

  Tomoko Monguchi, Tetsuya Hara, Minoru Hasokawa, Hideto Nakajima, Kenta Mori, Ryuji Toh, Yasuhiro Irino, Tatsuro Ishida, Ken-ichi Hirata, Masakazu Shinohara

  Jul. 2017, JOURNAL OF CARDIOLOGY, 70(1-2) (1-2), 121 - 127, English, International magazine

  [Refereed]

  Scientific journal


• Enhanced Impact of Cholesterol Absorption Marker on New Atherosclerotic Lesion Progression After Coronary Intervention During Statin Therapy

  Kenta Mori, Tatsuro Ishida, Shigeyasu Tsuda, Toshihiko Oshita, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Ryuji Toh, Ken-ichi Hirata

  2017, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 24(2) (2), 123 - 132, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Association between serum elaidic acid concentration and insulin resistance in two Japanese cohorts with different lifestyles

  Kiyotaka Itcho, Yoko Yoshii, Haruya Ohno, Kenji Oki, Masakazu Shinohara, Yasuhiro Irino, Ryuji Toh, Tatsuro Ishida, Ken-Ichi Hirata, Masayasu Yoneda

  Japan Atherosclerosis Society, 2017, Journal of Atherosclerosis and Thrombosis, 24(12) (12), 1206 - 1214, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A possible role for HLA-DRB1*04:06 in statin-related myopathy in Japanese patients

  Kimie Sai, Kouji Kajinami, Hironobu Akao, Mizuho Iwadare, Ryoko Sato-Ishida, Yasuyuki Kawai, Kenji Takeda, Takashi Tanimoto, Takashi Yamano, Takashi Akasaka, Tatsuro Ishida, Ken-ichi Hirata, Keijiro Saku, Shusuke Yagi, Takeshi Soeki, Masataka Sata, Masafumi Ueno, Shunichi Miyazaki, Aya Shiraki, Jun-ichi Oyama, Koichi Node, Koichi Sugamura, Hisao Ogawa, Kouichi Kurose, Keiko Maekawa, Yumiko Matsuzawa, Takuya Imatoh, Ryuichi Hasegawa, Yoshiro Saito

  Dec. 2016, DRUG METABOLISM AND PHARMACOKINETICS, 31(6) (6), 467 - 470, English, International magazine

  [Refereed]

  Scientific journal


• 2-Aminobutyric acid modulates glutathione homeostasis in the myocardium

  Yasuhiro Irino, Ryuji Toh, Manabu Nagao, Takeshige Mori, Tomoyuki Honjo, Masakazu Shinohara, Shigeyasu Tsuda, Hideto Nakajima, Seimi Satomi-Kobayashi, Toshiro Shinke, Hidekazu Tanaka, Tatsuro Ishida, Okiko Miyata, Ken-Ichi Hirata

  Nov. 2016, SCIENTIFIC REPORTS, 6, 36749 - 36749, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• beta-Hydroxybutyrate elevation as a compensatory response against oxidative stress in cardiomyocytes

  Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Takeshige Mori, Hideto Nakajima, Tetsuya Hara, Tomoyuki Honjo, Seimi Satomi-Kobayashi, Toshiro Shinke, Hidekazu Tanaka, Tatsuro Ishida, Ken-ichi Hirata

  Jul. 2016, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 475(4) (4), 322 - 328, English, International magazine

  [Refereed]

  Scientific journal


• Comparison of telmisartan/amlodipine and telmisartan/hydrochlorothiazide in the treatment of Japanese patients with uncontrolled hypertension: The TAT-Kobe study

  Kensuke Kondo, Ryuji Toh, Tatsuro Ishida, Kenta Mori, Tomoyuki Yasuda, Ken-Ichi Hirata

  Lippincott Williams and Wilkins, 2016, Blood Pressure Monitoring, 21(3) (3), 171 - 177, English, International magazine

  [Refereed]

  Scientific journal


• Dawn of a new era: The far lower, the far better low-density lipoprotein cholesterol story in Japan

  Tatsuro Ishida

  Japanese Circulation Society, 2016, Circulation Journal, 80(9) (9), 1903 - 1904, English, Domestic magazine

  [Refereed]

  Scientific journal


• Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan

  Kenta Mori, Tatsuro Ishida, Tomoyuki Yasuda, Minoru Hasokawa, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Hideto Nakajima, Masakazu Shinohara, Toshiro Shinke, Yasuhiro Irino, Ryuji Toh, Kunihiro Nishimura, Ken-ichi Hirata

  Sep. 2015, CIRCULATION JOURNAL, 79(9) (9), 2017 - +, English, Domestic magazine

  [Refereed]

  Scientific journal


• Trans-fatty acid promotes thrombus formation in mice by aggravating antithrombogenic endothelial functions via Toll-like receptors

  Kensuke Kondo, Tatsuro Ishida, Tomoyuki Yasuda, Hideto Nakajima, Kenta Mori, Nobuaki Tanaka, Takeshige Mori, Tomoko Monguchi, Masakazu Shinohara, Yasuhiro Irino, Ryuji Toh, Yoshiyuki Rikitake, Kazunobu Kiyomizu, Yoshiaki Tomiyama, Junichiro Yamamoto, Ken-ichi Hirata

  Apr. 2015, MOLECULAR NUTRITION & FOOD RESEARCH, 59(4) (4), 729 - 740, English, International magazine

  [Refereed]

  Scientific journal


• Combination of Invasive and Non-Invasive Vascular Examinations: Usefulness from the Preemptive Aspect

  Tomofumi Takaya, Tatsuro Ishida

  2015, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 22(10) (10), 1027 - 1029, English, Domestic magazine

  [Refereed]

  Scientific journal


• Administration of high dose eicosapentaenoic acid enhances anti-inflammatory properties of high-density lipoprotein in Japanese patients with dyslipidemia

  Nobuaki Tanaka, Tatsuro Ishida, Manabu Nagao, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kenta Mori, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Yasuhiro Irino, Ryuji Toh, Masakazu Shinohara, Ken-ichi Hirata

  Dec. 2014, ATHEROSCLEROSIS, 237(2) (2), 577 - 583, English, International magazine

  [Refereed]

  Scientific journal


• Endothelial Lipase

  安田知行, Ishida Tatsuro

  Jul. 2014, The Lipid, 25(3) (3), 78(274) - 85(281), Japanese

  [Refereed][Invited]

  Scientific journal


• 急性冠症候群発症時の血清および血栓中の脂肪酸組成(Serum and Thrombus Fatty Acid Composition at the Onset of Acute Coronary Syndrome)

  Yasuda Tomoyuki, Irino Yasuhiro, Shimizu Hiroki, Mori Kenta, Mori Takeshige, Hatazawa Keiko, Matsuzoe Hiroki, Tsuji Takayuki, Inoue Michihiko, Kumagai Hiroyuki, Takami Kaoru, Norisada Kazuko, Nakamura Hiroaki, Nanahoshi Masakazu, Kadotani Makoto, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi, Ohnishi Yoshio

  (一社)日本循環器学会, Mar. 2014, Circulation Journal, 78(Suppl.I) (Suppl.I), 31 - 32, English


• Plasma Activity of Endothelial Lipase Impacts High-Density Lipoprotein Metabolism and Coronary Risk Factors in Humans

  Li Sun, Tatsuro Ishida, Kazuya Miyashita, Noriaki Kinoshita, Kenta Mori, Tomoyuki Yasuda, Ryuji Toh, Katsuyuki Nakajima, Shigeyuki Imamura, Ken-ichi Hirata

  2014, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 21(4) (4), 313 - 321, English, Domestic magazine

  [Refereed]

  Scientific journal


• Serum myeloperoxidase/paraoxonase 1 ratio as potential indicator of dysfunctional high-density lipoprotein and risk stratification in coronary artery disease

  Yoko Haraguchi, Ryuji Toh, Minoru Hasokawa, Hideto Nakajima, Tomoyuki Honjo, Kazunori Otsui, Kenta Mori, Maki Miyamoto-Sasaki, Masakazu Shinohara, Kunihiro Nishimura, Tatsuro Ishida, Ken-ichi Hirata

  Elsevier Ireland Ltd, 2014, Atherosclerosis, 234(2) (2), 288 - 294, English, International magazine

  [Refereed]

  Scientific journal


• Vasospasm of Atherosclerotic Coronary Arteries Precipitates Acute Ischemic Myocardial Damage in Myocardial Infarction–Prone Strain of the Watanabe Heritable Hyperlipidemic Rabbits

  Masashi Shiomi, Tatsuro Ishida, Tsutomu Kobayashi, Norihisa Nitta, Akinaga Sonoda, Satoshi Yamada, Tomonari Koike, Nobue Kuniyoshi, Kiyoshi Murata, Ken-ichi Hirata, Takashi Ito, Peter Libby

  OBJECTIVE: This study tested the hypothesis that vasospasm can trigger coronary plaque injury and acute ischemic myocardial damage. APPROACH AND RESULTS: Myocardial infarction-prone strain of the Watanabe heritable hyperlipidemic rabbits received an intravenous bolus of ergonovine maleate (0.45 µmol/kg) during intravenous infusion of norepinephrine (12 nmol/kg per minute) to provoke coronary spasm in vivo. After this treatment, coronary angiography demonstrated vasospasm, and the ECG showed ischemic abnormalities (ST depression/elevation and T-wave inversion) in 77% of animals (23/30). These changes normalized after nitroglycerin injection. In rabbits that demonstrated these ECG findings for >20 minutes, echocardiograms showed left ventricular wall motion abnormality. Serum levels of heart-type fatty acid-binding protein, cardiac troponin-I, and myoglobin increased markedly 4 hours after spasm provocation. In coronary lesions of myocardial infarction-prone strain of the Watanabe heritable hyperlipidemic rabbits with provoked coronary spasm, we observed intimal injury in 60.9% in the form of endothelial cell protrusions (39.1%), denudation (30.4%), and macrophage extravasation (56.5%). Plaque disruption with luminal thrombus, however, was only seen in 2 of 23 animals (8.7%), and mural microthrombus was rarely observed (4.3%). CONCLUSIONS: These observations show that provocation of vasospasm in myocardial infarction-prone strain of the Watanabe heritable hyperlipidemic rabbits associates with subsequent ischemic myocardial damage. Although treatment with spasmogens altered aspects of plaque morphology, for example, endothelial protrusion and macrophage emigration, thrombosis was rare in these animals with chronic atherosclerotic disease.

  Ovid Technologies (Wolters Kluwer Health), Nov. 2013, Arteriosclerosis, Thrombosis, and Vascular Biology, 33(11) (11), 2518 - 2523, English, International magazine

  [Refereed]

  Scientific journal


• 食事による血管内皮リパーゼ誘導が血清HDLコレステロール値に及ぼす影響についての検討

  杜 隆嗣, Ishida Tatsuro, Hirata Ken-ichi

  Sep. 2013, 日本内分泌学会雑誌, 89(2号) (2号), 755, Japanese

  Research society


• Fasting serum concentration of apolipoprotein B48 represents residual risks in patients with new-onset and chronic coronary artery disease

  Kenta Mori, Tatsuro Ishida, Tomoyuki Yasuda, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Minoru Hasokawa, Hideto Nakajima, Yoko Haraguchi, Li Sun, Masakazu Shinohara, Ryuji Toh, Kunihiro Nishimura, Ken-ichi Hirata

  Jun. 2013, Clinica Chimica Acta, 421, 51 - 56, English, International magazine

  [Refereed]

  Scientific journal


• 冠スパズム誘導によるWHHLMIウサギの冠動脈プラーク傷害と急性心筋虚血の発生

  小池 智也, Ishida Tatsuro, 山田 悟士, 国吉 信恵, ユウ・イン, Hirata Ken-ichi, 伊藤 隆, 塩見 雅志

  Jun. 2013, 日本動脈硬化学会総会プログラム・抄録集, (45回) (45回), 236, Japanese

  Research society


• Nectin-Like Molecule-5 Regulates Intimal Thickening After Carotid Artery Ligation in Mice

  Fumie Kureha, Seimi Satomi-Kobayashi, Yoshiki Kubo, Mitsuo Kinugasa, Tatsuro Ishida, Yoshimi Takai, Ken-ichi Hirata, Yoshiyuki Rikitake

  Jun. 2013, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(6) (6), 1206 - +, English, International magazine

  [Refereed]

  Scientific journal


• Increased serum cholesterol esterification rates predict coronary heart disease and sudden death in a general population

  Shin-Ichiro Tanaka, Tomoyuki Yasuda, Tatsuro Ishida, Yoshio Fujioka, Takeshi Tsujino, Tetsuo Miki, Ken-Ichi Hirata

  May 2013, Arteriosclerosis, Thrombosis, and Vascular Biology, 33(5) (5), 1098 - 1104, English

  [Refereed]

  Scientific journal


• Endothelial Lipase Modulates Pressure Overload-Induced Heart Failure Through Alternative Pathway for Fatty Acid Uptake

  Hideto Nakajima, Tatsuro Ishida, Seimi Satomi-Kobayashi, Kenta Mori, Tetsuya Hara, Naoto Sasaki, Tomoyuki Yasuda, Ryuji Toh, Hidekazu Tanaka, Hiroya Kawai, Ken-ichi Hirata

  May 2013, HYPERTENSION, 61(5) (5), 1002 - +, English, International magazine

  [Refereed]

  Scientific journal


• Pitavastatin increases HDL particles functionally preserved with cholesterol efflux capacity and antioxidative actions in dyslipidemic patients

  Maki Miyamoto-Sasaki, Tomoyuki Yasuda, Tomoko Monguchi, Hideto Nakajima, Kenta Mori, Ryuji Toh, Tatsuro Ishida, Ken-Ichi Hirata

  2013, Journal of Atherosclerosis and Thrombosis, 20(9) (9), 708 - 716, English, Domestic magazine

  [Refereed]

  Scientific journal


• Isolated Primary Cardiac Sarcoidosis Presenting as Acute Heart Failure

  Yoichiro Sugizaki, Hidekazu Tanaka, Junichi Imanishi, Akihide Konishi, Tomoya Yamashita, Toshiro Shinke, Tatsuro Ishida, Hiroya Kawai, Ken-ichi Hirata

  2013, INTERNAL MEDICINE, 52(1) (1), 71 - 74, English, Domestic magazine

  [Refereed]

  Scientific journal


• ELISA System for Human Endothelial Lipase

  Tatsuro Ishida, Kazuya Miyashita, Mamoru Shimizu, Noriaki Kinoshita, Kenta Mori, Li Sun, Tomoyuki Yasuda, Shigeyuki Imamura, Katsuyuki Nakajima, Kimber L. Stanhope, Peter J. Havel, Ken-ichi Hirata

  Dec. 2012, CLINICAL CHEMISTRY, 58(12) (12), 1656 - 1664, English, International magazine

  [Refereed]

  Scientific journal


• Comparison of medium-dose losartan/hydrochlorothiazide and maximal-dose angiotensin II receptor blockers in the treatment of Japanese patients with uncontrolled hypertension: the Kobe-CONNECT Study

  Ryuji Toh, Tatsuro Ishida, Kunihiro Nishimura, Hidemi Nonaka, Yoshimichi Inoue, Yasuo Kitagawa, Masakuni Suematsu, Takashi Miki, Noriaki Emoto, Ken-ichi Hirata

  Nov. 2012, HYPERTENSION RESEARCH, 35(11) (11), 1080 - 1086, English, International magazine

  [Refereed]

  Scientific journal


• Effect of Cytochrome P450 2C19 Polymorphism on Target Lesion Outcome After Drug-Eluting Stent Implantation in Japanese Patients Receiving Clopidogrel

  Ryo Nishio, Toshiro Shinke, Hiromasa Otake, Takahiro Sawada, Yoko Haraguchi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Junya Shite, Ken-ichi Hirata

  Oct. 2012, CIRCULATION JOURNAL, 76(10) (10), 2348 - 2355, English, Domestic magazine

  [Refereed]

  Scientific journal


• 高血圧治療におけるアンジオテンシンII受容体拮抗薬(ARB)/利尿剤併用療法とアンジオテンシンII受容体拮抗薬(ARB)/Ca拮抗薬併用療法との有用性比較に関する研究

  Ishida Tatsuro, Toh Ryuji, Yasuda Tomoyuki, Hirata Kenichi

  Sep. 2012, 日本高血圧学会総会プログラム・抄録集35回, 468, Japanese

  Research society


• Identification of Biomarkers of Stent Restenosis With Serum Metabolomic Profiling Using Gas Chromatography/Mass Spectrometry

  Minoru Hasokawa, Masakazu Shinohara, Hiroshi Tsugawa, Takeshi Bamba, Eiichiro Fukusaki, Shin Nishiumi, Kunihiro Nishimura, Masaru Yoshida, Tatsuro Ishida, Ken-ichi Hirata

  Aug. 2012, CIRCULATION JOURNAL, 76(8) (8), 1864 - 1873, English, Domestic magazine

  [Refereed]

  Scientific journal


• Osteoblast-like Differentiation of Cultured Human Coronary Artery Smooth Muscle Cells by Bone Morphogenetic Protein Endothelial Cell Precursor-derived Regulator (BMPER)

  Seimi Satomi-Kobayashi, Mitsuo Kinugasa, Reiko Kobayashi, Kinta Hatakeyama, Yusuke Kurogane, Tatsuro Ishida, Noriaki Emoto, Yujiro Asada, Yoshimi Takai, Ken-ichi Hirata, Yoshiyuki Rikitake

  Aug. 2012, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(36) (36), 30336 - 30345, English, International magazine

  [Refereed]

  Scientific journal


• The effect of poloxamer 407 on the functional properties of HDL in mice

  Tomoyuki Yasuda, Thomas P. Johnston, Masakazu Shinohara, Michihiko Inoue, Tatsuro Ishida

  May 2012, JOURNAL OF PHARMACY AND PHARMACOLOGY, 64(5) (5), 677 - 687, English, International magazine

  Scientific journal


• Endothelial lipase mediates HDL levels in normal and hyperlipidemic rabbits

  Jifeng Zhang, Jifeng Zhang, Ying Yu, Kae Nakamura, Tomonari Koike, Ahmed Bilal Waqar, Xiaowei Zhang, Enqi Liu, Kazutoshi Nishijima, Shuji Kitajima, Masashi Shiomi, Zhongxia Qi, Jingwei Yu, Mark J. Graham, Rosanne M. Crooke, Tatsuro Ishida, Ken ichi Hirata, Eva Hurt-Camejo, Y. Eugene Chen, Jianglin Fan

  Aim: Existing evidence suggests that endothelial lipase (EL) plays an important role in high-densitylipoprotein (HDL) metabolism. Because rabbits are a useful animal model for the study of human lipid metabolism and atherosclerosis, we characterized rabbit EL (rEL) expression and investigated its relationship with plasma HDL levels in normal and hyperlipidemic rabbits. Methods: We cloned the rEL cDNA and analyzed the EL tissue expression using Northern blotting, real-time RT-PCR, Western blotting, and in situ hybridization. We evaluated the effects of rEL antisense on plasma HDL levels. Results: We found that rEL mRNA was highly expressed in cholesterol synthesis-related organs, including the liver, testis, and adrenal along with its expression in the lung, kidney, bone marrow, and small intestine. Interestingly, Watanabe heritable hyperlipidemic (WHHL) rabbits, a model of human familial hypercholesterolemia, had lower plasma levels of HDLs than normal rabbits. The plasma HDL levels in WHHL rabbits were inversely associated with high levels of plasma rEL proteins and hepatic expression of rEL mRNA. Injection of rEL-specific antisense oligonucleotides into rabbits resulted in the el

  Apr. 2012, Journal of Atherosclerosis and Thrombosis, 19, 213 - 226


• FGD5 Mediates Proangiogenic Action of Vascular Endothelial Growth Factor in Human Vascular Endothelial Cells

  Yusuke Kurogane, Muneaki Miyata, Yoshiki Kubo, Yuichi Nagamatsu, Ramendra K. Kundu, Akiyoshi Uemura, Tatsuro Ishida, Thomas Quertermous, Ken-ichi Hirata, Yoshiyuki Rikitake

  Apr. 2012, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 32(4) (4), 988 - U316, English, International magazine

  Scientific journal


• HMG-CoA還元酵素阻害薬(スタチン)投与後に増加したHDLの抗動脈硬化作用の検討

  Yasuda Tomoyuki, Ishida Tatsuro, Hirata Kenichi

  Feb. 2012, 日本内科学会雑誌, 101(Suppl.) (Suppl.), 279, Japanese

  [Refereed]

  Scientific journal


• Expression of Endothelial Lipase Correlates with the Size of Neointima in a Murine Model of Vascular Remodeling

  Li Sun, Tatsuro Ishida, Takeaki Okada, Tomoyuki Yasuda, Tetsuya Hara, Ryuji Toh, Masakazu Shinohara, Tomoya Yamashita, Yoshiyuki Rikitake, Ken-ichi Hirata

  2012, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 19(12) (12), 1110 - 1127, English, Domestic magazine

  [Refereed]

  Scientific journal


• Orally Administered Eicosapentaenoic Acid Induces Rapid Regression of Atherosclerosis Via Modulating the Phenotype of Dendritic Cells in LDL Receptor-Deficient Mice

  Kenji Nakajima, Tomoya Yamashita, Tomoyuki Kita, Masafumi Takeda, Naoto Sasaki, Kazuyuki Kasahara, Masakazu Shinohara, Yoshiyuki Rikitake, Tatsuro Ishida, Mitsuhiro Yokoyama, Ken-ichi Hirata

  Sep. 2011, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 31(9) (9), 1963 - U124, English, International magazine

  [Refereed]

  Scientific journal


• Species differences of macrophage very low-density-lipoprotein (VLDL) receptor protein expression

  Sadao Takahashi, Takashi Ito, Yasuo Zenimaru, Jinya Suzuki, Isamu Miyamori, Masao Takahashi, Masafumi Takahashi, Takafumi Ishida, Tatsuro Ishida, Ken-ichi Hirata, Tokuo T. Yamamoto, Tadao Iwasaki, Hiroaki Hattori, Masashi Shiomi

  Apr. 2011, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 407(4) (4), 656 - 662, English, International magazine

  [Refereed]

  Scientific journal


• Impact of cytochrome P450 2C19*2 polymorphism on intra-stent thrombus after drug-eluting stent implantation in Japanese patients receiving clopidogrel

  Takahiro Sawada, Toshiro Shinke, Junya Shite, Tomoyuki Honjo, Yoko Haraguchi, Ryo Nishio, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Hiroyuki Kawamori, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Ken-ichi Hirata

  2011, Circulation Journal, 75(1) (1), 99 - 105, English, Domestic magazine

  [Refereed]

  Scientific journal


• Targeted deletion of endothelial lipase increases HDL particles with anti-inflammatory properties both in vitro and in vivo

  Tetsuya Hara, Tatsuro Ishida, Yoko Kojima, Hanayo Tanaka, Tomoyuki Yasuda, Masakazu Shinohara, Ryuji Toh, Ken-ichi Hirata

  Jan. 2011, JOURNAL OF LIPID RESEARCH, 52(1) (1), 57 - 67, English, International magazine

  Scientific journal


• Pitavastatin Reduces Elevated IL-18 levels in Japanese Subjects with Hypercholesterolemia: Sub-analysis of Kansai Investigation of Statin for Hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN)

  Yoshio Fujioka, Akira Fukuda, Tatsuro Ishida, Shinji Kagimoto, Yoshio Nakamura, Akane Iwakura, Kyoko Hara, Taizo Yamamoto, Akira Kuroe, Michihiro Ohya, Shinpei Fujimoto, Yoshiyuki Hamamoto, Sachiko Honjo, Hiroki Ikeda, Koichiro Nabe, Kinsuke Tsuda, Ataru Taniguchi, Kiyoshi Tanaka, Hiroyuki Koshiyama, Noriaki Kume, Ken-ichi Hirata

  2011, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 18(1) (1), 8 - 15, English

  [Refereed]

  Scientific journal


• Oral Administration of an Active Form of Vitamin D-3 (Calcitriol) Decreases Atherosclerosis in Mice by Inducing Regulatory T Cells and Immature Dendritic Cells With Tolerogenic Functions

  Masafumi Takeda, Tomoya Yamashita, Naoto Sasaki, Kenji Nakajima, Tomoyuki Kita, Masakazu Shinohara, Tatsuro Ishida, Ken-ichi Hirata

  Dec. 2010, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30(12) (12), 2495 - U305, English, International magazine

  [Refereed]

  Scientific journal


• Endothelial cell-selective adhesion molecule modulates atherosclerosis through plaque angiogenesis and monocyte-endothelial interaction

  Michihiko Inoue, Tatsuro Ishida, Tomoyuki Yasuda, Ryuji Toh, Tetsuya Hara, Husni M. Cangara, Yoshiyuki Rikitake, Kazuki Taira, Li Sun, Ramendra K. Kundu, Thomas Quertermous, Ken-ichi Hirata

  Sep. 2010, MICROVASCULAR RESEARCH, 80(2) (2), 179 - 187, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A rare case of pericardial hemangioma with bloody pericardial effusion.

  Kazuya Omura, Tetsuari Onishi, Kohei Yamawaki, Alaa Marbrouk Salem Omar, Maki Kanzawa, Tatsuro Ishida, Junya Shite, Hiroya Kawai, Tomoo Itoh, Yutaka Okita, Ken-Ichi Hirata

  A 78-year-old woman presented with leg edema and exertional dyspnea. Echocardiography revealed a smooth-surfaced mass adjacent to the left atrium in the pericardial cavity with a massive pericardial effusion. Pericardiocentesis resulted in the drainage of a bloody effusion. Magnetic resonance imaging documented a mass having isointensity on T1- and hyperintensity on T2-weighted images. In addition, the mass was evenly enhanced with gadolinium 10 min after administration. By surgical resection, a 25 × 30 mm in diameter tumor was excised together with a left atrial wall portion. The pathological examination made a final diagnosis as hemangioma. Based on these findings, we report the rare case of pericardial hemangioma with a bloody pericardial effusion, which presented with heart failure symptoms. Although bloody pericardial effusion is considered a supportive characteristic for malignant tumors, we could preoperatively make a precise diagnosis of benign hemangioma by means of several imaging modalities.

  Aug. 2010, Journal of cardiology cases, 2(1) (1), e15-e19, English, Domestic magazine


• Role of endothelial cell-selective adhesion molecule in hematogeneous metastasis

  Husni M. Cangara, Tatsuro Ishida, Tetsuya Hara, Li Sun, Ryuji Toh, Yoshiyuki Rikitake, Ramendra K. Kundu, Thomas Quertermous, Ken-ichi Hirata, Yoshitake Hayashi

  Jul. 2010, MICROVASCULAR RESEARCH, 80(1) (1), 133 - 141, English

  [Refereed]

  Scientific journal


• Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo

  Yoko Kojima, Tatsuro Ishida, Li Sun, Tomoyuki Yasuda, Ryuji Toh, Yoshiyuki Rikitake, Akira Fukuda, Noriaki Kume, Hiroyuki Koshiyama, Ataru Taniguchi, Ken-ichi Hirata

  Jul. 2010, CARDIOVASCULAR RESEARCH, 87(2) (2), 385 - 393, English, International magazine

  [Refereed]

  Scientific journal


• Role of endothelial cell-selective adhesion molecule in hematogeneous metastasis

  Husni M. Cangara, Tatsuro Ishida, Tetsuya Hara, Li Sun, Ryuji Toh, Yoshiyuki Rikitake, Ramendra K. Kundu, Thomas Quertermous, Ken-ichi Hirata, Yoshitake Hayashi

  Jul. 2010, Microvascular Research, 80(1) (1), 133 - 141, English, International magazine

  [Refereed]

  Scientific journal


• Interaction of endothelial cell-selective adhesion molecule and MAGI-1 promotes mature cell-cell adhesion via activation of RhoA

  Ritsuko Kimura, Tatsuro Ishida, Masamitsu Kuriyama, Ken-ichi Hirata, Yoshitake Hayashi

  Apr. 2010, GENES TO CELLS, 15(4) (4), 385 - 396, English, International magazine

  [Refereed]

  Scientific journal


• 冠動脈疾患と血清ミエロペルオキシダーゼ(MPO) ステント内再狭窄予知マーカーとしての有用性

  Toh Ryuji, Ishida Tatsuro, Hirata Kenichi

  Mar. 2010, 大和証券ヘルス財団研究業績集, 巻, 33号, pp. 131-136, Japanese

  [Refereed]

  Scientific journal


• 治療法の選択に苦慮した重症肺血栓塞栓症の1例

  Ishida Tatsuro, Kawai Hiroya, Hirata Kenichi

  May 2009, Therapeutic Research, 30巻, 5号, pp. 577-580, Japanese

  [Refereed]

  Scientific journal


• RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice

  Li Sun, Tatsuro Ishida, Tomoyuki Yasuda, Yoko Kojima, Tomoyuki Honjo, Yasuhiko Yamamoto, Hiroshi Yamamoto, Shun Ishibashi, Ken-ichi Hirata, Yoshitake Hayashi

  May 2009, CARDIOVASCULAR RESEARCH, 82(2) (2), 371 - 381, English, International magazine

  [Refereed]

  Scientific journal


• Endothelial cell-selective adhesion molecule regulates albuminuria in diabetic nephropathy

  Tetsuya Hara, Tatsuro Ishida, Husni M. Cangara, Ken-ichi Hirata

  May 2009, MICROVASCULAR RESEARCH, 77(3) (3), 348 - 355, English, International magazine

  Scientific journal


• 抗精神病薬治療中に発症した慢性心筋炎の一剖検例

  Ishida Tatsuro, Kawai Hiroya, Hirata Kenichi

  Apr. 2009, Circulation Journal, 73巻, Suppl.II, pp. 948-948, Japanese

  International conference proceedings


• Targeted inactivation of endothelial lipase attenuates lung allergic inflammation through raising plasma HDL level and inhibiting eosinophil infiltration

  Hiroshi Otera, Tatsuro Ishida, Teruaki Nishiuma, Kazuyuki Kobayashi, Yoshikazu Kotani, Tomoyuki Yasuda, Ramendra K. Kundu, Thomas Quertermous, Ken-ichi Hirata, Yoshihiro Nishimura

  Apr. 2009, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 296(4) (4), L594 - L602, English, International magazine

  [Refereed]

  Scientific journal


• CPAより蘇生に成功し、ICD植込みを行った冠攣縮性狭心症の一症例

  Ishida Tatsuro, Kawai Hiroya, Hirata Kenichi

  Apr. 2009, Circulation Journal, 73巻, Suppl.II, pp. 943-943, Japanese

  International conference proceedings


• 生活習慣病における医学、薬学の萠芽的研究 生活習慣病に合併する低HDL血症の成因における血管内皮リパーゼの関与

  Ishida Tatsuro

  Feb. 2009, 医科学応用研究財団研究報告, 26巻, , pp. 155-159, Japanese

  [Refereed]

  Scientific journal


• Role of endothelial lipase in plasma HDL levels in a murine model of hypertriglyceridemia

  Hanayo Tanaka, Tatsuro Ishida, Thomas P. Johnston, Tomoyuki Yasuda, Tomomi Ueyama, Yoko Kojima, Ramendra K. Kundu, Thomas Quertermous, Yuichi Ishikawa, Ken-Ichi Hirata

  Japan Atherosclerosis Society, 2009, Journal of Atherosclerosis and Thrombosis, 16(4) (4), 327 - 338, English, Domestic magazine

  [Refereed]

  Scientific journal


• 透析患者の動脈硬化性病変進展における低栄養、炎症と血管内皮リパーゼの関係

  藤井 秀毅, 福田 亨, 田中 元子, 児島 陽子, 石田 達郎, 平田 健一, 深川 雅史

  (公財)日本腎臓財団, Nov. 2008, 腎臓, 31(2) (2), 144 - 150, Japanese


• 心臓再同期療法を施行し術直後より左室拡張能の改善を認めた心ファブリー病の一例

  Ishida Tatsuro, Kawai Hiroya, Hirata Kenichi

  Oct. 2008, Circulation Journal, 72巻, Suppl.III, pp. 1102-1102, Japanese

  International conference proceedings


• 心臓再同期療法を施行した心ファブリー病の一例

  Kawai Hiroya, Ishida Tatsuro, Hirata Kenichi

  Aug. 2008, 日本心臓病学会誌, 2巻, Suppl.I, pp. 514-514, Japanese

  International conference proceedings


• 動脈硬化形成過程におけるendothelial-selective adhesion molecule(ESAM)の役割について

  Ishida Tatsuro, Hirata Kenichi

  Jun. 2008, 日本動脈硬化学会総会プログラム・抄録集, 巻, 40回, pp. 202-202, Japanese

  International conference proceedings


• 抗CD3抗体の経口投与はCD4 LAP 制御性T細胞を誘導して動脈硬化形成を抑制する(英語)

  Ishida Tatsuro, Hirata Kenichi

  Jun. 2008, 日本動脈硬化学会総会プログラム・抄録集, 巻, 40回, pp. 202-202, Japanese

  International conference proceedings


• 血管内皮リパーゼの血中濃度と血清HDL値との関係

  Ishida Tatsuro, Hirata Kenichi

  Feb. 2008, 日本内科学会雑誌, 97巻, Suppl., pp. 142-142, Japanese

  International conference proceedings


• Putative role of endothelial lipase in dialysis patients with hypoalbuminemia and inflammation

  Hideki Fujii, Akira Fukuda, Motoko Tanaka, Yoko Kojima, Tatsuro Ishida, Ken-ichi Hirata, Masafumi Fukagawa

  2008, AMERICAN JOURNAL OF NEPHROLOGY, 28(6) (6), 974 - 981, English, International magazine

  [Refereed]

  Scientific journal


• Endothelial lipase is increased by inflammation and promotes LDL uptake in macrophages.

  Tomoyuki Yasuda, Ken-Ichi Hirata, Tatsuro Ishida, Yoko Kojima, Hanayo Tanaka, Takeaki Okada, Thomas Quertermous, Mitsuhiro Yokoyama

  AIM: Endothelial lipase (EL) is a member of the lipoprotein lipase family that regulates HDL metabolism. EL is known to act as a bridging molecule for monocytes or lipoproteins in vascular endothelial cells. We investigated the role and regulatory mechanisms of EL expression in macrophages. METHODS: Macrophages originating from wild-type (EL+/+) and EL-deficient (EL-/-) mice were stimulated with lipopolysaccharide (LPS). The expression of EL mRNA was evaluated by northern blotting. DiI-LDL was used to measure the uptake of native low-density lipoprotein (nLDL). RESULTS: LPS increased EL mRNA levels by increasing intracellular oxidative stress in the macrophages. LPS did not affect EL expression in macrophages derived from Toll-like receptor 4 (TLR4) gene mutant mice, C3H/HeJ. The uptake of nLDL after LPS-treatment was significantly lower in macrophages from EL-/- mice than those from EL+/+ mice. Simvastatin suppressed the LPS-induced upregulation of EL expression and uptake of nLDL. CONCLUSIONS: EL expression is upregulated by LPS via TLR4 and promotes the uptake of nLDL by macrophages. Simvastatin inhibits the LPS-induced up-regulation and uptake in macrophages. Thus, our findings provide a novel role for EL in lipoprotein metabolism and would expand the range of anti-atherogenic effects of statins.

  Aug. 2007, Journal of atherosclerosis and thrombosis, 14(4) (4), 192 - 201, English, Domestic magazine

  Scientific journal


• Echocardiographic findings of intracardiac mass.

  Hidekazu Tanaka, Hiroya Kawai, Tatsuro Ishida, Akihiro Yoshida, Mitsuhiro Yokoyama

  Aug. 2007, Journal of cardiology, 50(2) (2), 155 - 7, English, International magazine

  Scientific journal


• Endothelial Lipase Gene Polymorphism is Associated With Acute Myocardial Infarction, Independently of High-Density Lipoprotein-Cholesterol Levels

  HIRATA KENICHI, ISHIDA TAKESHI, HASHIMOTO MASAYOSHI, AKITA HOZUKA

  BACKGROUND: Endothelial lipase (EL) is a major determinant of high-density lipoprotein-cholesterol (HDL-C) metabolism and promotes monocytes recruitment. The local expression of EL could influence atherogenesis directly, in addition to its systemic role in HDL metabolism. The EL gene has a common 584C/T polymorphism, but it is unclear whether this polymorphism is associated with HDL-C levels or acute myocardial infarction (AMI). METHODS AND RESULTS: A case-control study of 107 AMI patients and 107 control subjects was conducted. T allele frequency was lower in the AMI group than in controls (0.18 vs 0.26, p<0.05). No significant association was found between the 584C/T polymorphism and HDL-C levels. Multivariate regression analyses showed that the association of the T allele with AMI was statistically significant and independent of other risk factors when age, sex, hypertension, hypercholesterolemia, and diabetes mellitus were included in the analyses (odds ratio (OR), 0.52; 95% confidence interval (95% CI) 0.28-0.98; p=0.04). However, when smoking status was included, the association of the T allele with AMI did not remain statistically significant (OR, 0.61; 95% CI 0.32-1.18; p=0.14). CONCLUSIONS: The 584C/T polymorphism of the EL gene was associated with AMI independently of HDL-C levels and thus may be involved in the pathogenesis of AMI.

  Jun. 2007, Circulation Journal, Vol. 71, No. 6, pp. 842-6(6) (6), 842 - 6, English, Domestic magazine

  Scientific journal


• Ventilator-induced lung injury is reduced in transgenic mice that overexpress endothelial nitric oxide synthase.

  Kaori Takenaka, Yoshihiro Nishimura, Teruaki Nishiuma, Akihiro Sakashita, Tomoya Yamashita, Kazuyuki Kobayashi, Miyako Satouchi, Tatsuro Ishida, Seinosuke Kawashima, Mitsuhiro Yokoyama

  Although mechanical ventilation (MV) is an important supportive strategy for patients with acute respiratory distress syndrome, MV itself can cause a type of acute lung damage termed ventilator-induced lung injury (VILI). Because nitric oxide (NO) has been reported to play roles in the pathogenesis of acute lung injury, the present study explores the effects on VILI of NO derived from chronically overexpressed endothelial nitric oxide synthase (eNOS). Anesthetized eNOS-transgenic (Tg) and wild-type (WT) C57BL/6 mice were ventilated at high or low tidal volume (Vt; 20 or 7 ml/kg, respectively) for 4 h. After MV, lung damage, including neutrophil infiltration, water leakage, and cytokine concentration in bronchoalveolar lavage fluid (BALF) and plasma, was evaluated. Some mice were given N(omega)-nitro-L-arginine methyl ester (L-NAME), a potent NOS inhibitor, via drinking water (1 mg/ml) for 1 wk before MV. Histological analysis revealed that high Vt ventilation caused severe VILI, whereas low Vt ventilation caused minimal VILI. Under high Vt conditions, neutrophil infiltration and lung water content were significantly attenuated in eNOS-Tg mice compared with WT animals. The concentrations of macrophage inflammatory protein-2 in BALF and plasma, as well as plasma tumor necrosis factor-alpha and monocyte chemoattractant protein-1, also were decreased in eNOS-Tg mice. L-NAME abrogated the beneficial effect of eNOS overexpression. In conclusion, chronic eNOS overexpression may protect the lung from VILI by inhibiting the production of inflammatory chemokines and cytokines that are associated with neutrophil infiltration into the air space.

  Jun. 2006, American journal of physiology. Lung cellular and molecular physiology, 290(6) (6), L1078-86, English, International magazine

  Scientific journal


• 善玉コレステロールの制御機構の解明と生活習慣との関係

  ISHIDA, Tatsuro, HIRATA, Kenichi, YOKOYAMA, Mitsuhiro

  Mar. 2006, 健康医科学研究助成論文集, 21号, pp.11-18, Japanese

  Scientific journal


• 動脈硬化Update 2005 血管内皮リパーゼのHDL代謝と血管病変形成過程における役割

  児島陽子, HIRATA, Kenichi, ISHIDA, Tatsuro, 安田知行, YOKOYAMA, Mitsuhiro

  Jan. 2006, Therapeutic Research, 27巻, 1号, pp.69-69, Japanese

  International conference proceedings


• Xenogenic smooth muscle cell immunization reduces neointimal formation in balloon-injured rabbit carotid arteries

  M Shinohara, S Kawashima, T Yamashita, T Takaya, R Toh, T Ishida, T Ueyama, N Inoue, KI Hirata, M Yokoyama

  Nov. 2005, CARDIOVASCULAR RESEARCH, 68(2) (2), 249 - 258, English, International magazine

  Scientific journal


• 血管内皮リパーゼはマウス血管リモデリング形成を制御する

  岡田武哲, HIRATA, Kenichi, ISHIDA, Tatsuro, 児島陽子, 安田知行, 田中華代, 平和樹, YOKOYAMA, Mitsuhiro

  Oct. 2005, 脈管学, 45巻, 10号, pp.824-824, Japanese

  International conference proceedings


• 高中性脂肪血症にともなう低HDL血症における血管内皮リパーゼの役割

  田中華代, HIRATA, Kenichi, ISHIDA, Tatsuro, 児島陽子, 岡田武哲, 平和樹, YOKOYAMA, Mitsuhiro

  Jul. 2005, 日本動脈硬化学会総会プログラム・抄録集, pp.214-214, Japanese

  [Refereed]

  International conference proceedings


• Increased expression of endothelial lipase in rat models of hypertension

  Y Shimokawa, K Hirata, T Ishida, Y Kojima, N Inoue, T Quertermous, M Yokoyama

  Jun. 2005, CARDIOVASCULAR RESEARCH, 66(3) (3), 594 - 600, English, International magazine

  Scientific journal


• 血管内皮リパーゼは血管壁への単核細胞接着を仲介する 炎症における役割の可能性(Endothelial lipase mediates monocyte adhesion to the vessel wall: A potential role in inflammation)

  児島陽子, HIRATA, Kenichi, ISHIDA, Tatsuro, 下川泰史, INOUE,Nobutaka, KAWASHIMA, Seinosuke, YOKOYAMA, Mitsuhiro

  Jan. 2005, 血管, 28巻, 1号, pp. 23-23, Japanese

  International conference proceedings


• Endothelial lipase遺伝子多型は急性心筋梗塞の発症と関連する

  清水政克, KANAZAWA, Kenji, HIRATA, Kenichi, ISHIDA, Tatsuro, 松田康章, MIYAMOTO, Yoshitomo, AKITA, Hozuka, YOKOYAMA, Mitsuhiro

  Jan. 2005, 血管, 28巻, 1号, pp. 26-26, Japanese

  International conference proceedings


• Endothelial lipase modulates monocyte adhesion to the vessel wall - A potential role in inflammation

  Y Kojma, K Hirata, T Ishida, Y Shimokawa, N Inoue, S Kawashima, T Quertermous, M Yokoyama

  Dec. 2004, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(52) (52), 54032 - 54038, English, International magazine

  [Refereed]

  Scientific journal


• Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice

  T Ishida, SSY Choi, RK Kundu, J Spin, T Yamashita, K Hirata, Y Kojima, M Yokoyama, AD Cooper, T Quertermous

  Oct. 2004, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(43) (43), 45085 - 45092, English

  [Refereed]

  Scientific journal


• 血管細胞とマクロファージの接着における血管内皮リパーゼの役割

  児島陽子, HIRATA, Kenichi, ISHIDA, Tatsuro, INOUE,Nobutaka, KAWASHIMA, Seinosuke, YOKOYAMA, Mitsuhiro

  Sep. 2004, 脈管学, 44巻, 9号, pp. 551-551, Japanese

  International conference proceedings


• スタチンによる血管内皮リパーゼの発現調節

  児島陽子, HIRATA, Kenichi, ISHIDA, Tatsuro, INOUE,Nobutaka, 川嶋成之亮, YOKOYAMA, Mitsuhiro

  Jul. 2004, 日本動脈硬化学会総会プログラム・抄録集, pp. 199-199, Japanese

  International conference proceedings


• Endothelial lipase is synthesized by hepatic and aorta endothelial cells and its expression is altered in apoE-deficient mice

  Yu Kenneth C-W, David Christopher, Kadambi Sujata, Stahl Andreas, Hirata Ken-Ichi, ISHIDA, Tatsuro, Quertermous Thomas, Cooper Allen D, Choi Sungshin Y

  Jun. 2004, Journal Of Lipid Research, Vol. 45, No. 9, pp. 1614-1623, 1614 - 1623, English

  [Refereed]

  Scientific journal


• An anti-proliferative gene BTG1 regulates angiogenesis in vitro

  K Iwai, K Hirata, T Ishida, S Takeuchi, T Hirase, Y Rikitake, Y Kojima, N Inoue, S Kawashima, M Yokoyama

  Apr. 2004, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 316(3) (3), 628 - 635, English, International magazine

  [Refereed]

  Scientific journal


• Molecular cloning of nonsecreted endothelial cell-derived lipase isoforms

  T Ishida, Z Zheng, HL Dichek, HJ Wang, Moreno, I, E Yang, RK Kundu, S Talbi, KI Hirata, LL Leung, T Quertermous

  Jan. 2004, GENOMICS, 83(1) (1), 24 - 33, English

  [Refereed]

  Scientific journal


• アミオダロン加療中に間質性肺炎,薬剤性肝炎及び膵炎を伴った陳旧性心筋梗塞の1例

  小林憲恭, KITAZAWA, Souhei, KITAZAWA, Riko, KONDO, Takeshi, 藤本昌代, 岸本健太, ISHIDA, Tatsuro, INOUE,Nobutaka, YOKOYAMA, Mitsuhiro, MAEDA,Sakan

  Oct. 2003, 診断病理, 20巻, 4号, pp. 328-330, 328 - 330, Japanese

  [Refereed]

  Scientific journal


• 動脈硬化防御機構とコレステロール逆転送系 内皮由来リパーゼは血清HDLコレステロール値の主要な規定因子である

  HIRATA, Kenichi, ISHIDA, Tatsuro, SungshinChoi, AllenCooper, ThomasQuertermous, 児島陽子, 平瀬徹明, INOUE,Nobutaka, KAWASHIMA, Seinosuke, YOKOYAMA, Mitsuhiro

  Sep. 2003, 日本動脈硬化学会総会プログラム・抄録集, pp. 121-121, Japanese

  International conference proceedings


• 全身性炎症におけるマクロファージと血管細胞との接着における内皮由来リパーゼの役割

  児島陽子, HIRATA, Kenichi, ISHIDA, Tatsuro, 岩井健二, 下川泰史, INOUE,Nobutaka, 川嶋成之亮, YOKOYAMA, Mitsuhiro

  Sep. 2003, 日本動脈硬化学会総会プログラム・抄録集, pp. 168-168, Japanese

  International conference proceedings


• 血管壁細胞におけるリゾフォスファチジルコリン受容体の発現と機能

  岩井健二, HIRATA, Kenichi, RIKITAKE, Yoshiyuki, ISHIDA, Tatsuro, 児島陽子, 下川泰史, 平瀬徹明, INOUE,Nobutaka, 川嶋成之亮, YOKOYAMA, Mitsuhiro

  Sep. 2003, 日本動脈硬化学会総会プログラム・抄録集, pp. 171-171, Japanese

  International conference proceedings


• 血管病研究の新しい展開 血管内皮リパーゼの病的血管壁での発現制御とその機能

  ISHIDA, Tatsuro, HIRATA, Kenichi, 児島陽子, 岩井健二, YOKOYAMA, Mitsuhiro

  Sep. 2003, 日本動脈硬化学会総会プログラム・抄録集, pp. 129-129, Japanese

  International conference proceedings


• ラット内皮由来リパーゼのクローニングと高血圧モデルラットにおける発現制御の解析

  下川泰史, HIRATA, Kenichi, 児島陽子, 岩井健二, ISHIDA, Tatsuro, 平瀬徹明, INOUE,Nobutaka, KAWASHIMA, Seinosuke, YOKOYAMA, Mitsuhiro

  Sep. 2003, 日本動脈硬化学会総会プログラム・抄録集, pp. 158-158, Japanese

  International conference proceedings


• Targeted disruption of endothelial cell-selective adhesion molecule inhibits angiogenic processes in vitro and in vivo

  T Ishida, RK Kundu, E Yang, K Hirata, YD Ho, T Quertermous

  Sep. 2003, JOURNAL OF BIOLOGICAL CHEMISTRY, 278(36) (36), 34598 - 34604, English

  [Refereed]

  Scientific journal


• Immunohistochemical localization of endothelial cell-derived lipase in atherosclerotic human coronary arteries

  H Azumi, K Hirata, T Ishida, Y Kojiam, Y Rikitake, S Takeuchi, N Inoue, S Kawashima, Y Hayashi, H Itoh, T Quertermous, M Yokoyama

  Jun. 2003, CARDIOVASCULAR RESEARCH, 58(3) (3), 647 - 654, English, International magazine

  [Refereed]

  Scientific journal


• Endothelial lipase is a major determinant of HDL level

  Tatsuro Ishida, Sungshin Choi, Ramendra K. Kundu, Ken-ichi Hirata, Edward M. Rubin, Allen D. Cooper, Thomas Quertermous

  The American Society for Clinical Investigation, 2003, Journal of Clinical Investigation, 111(3) (3), 347 - 355, English

  [Refereed]

  Scientific journal


• Decreased expression of arginase II in the kidneys of Dahl salt-sensitive rats.

  Sachiyo Iwata, Takeshi Tsujino, Yoshihiro Ikeda, Tatsuro Ishida, Tomomi Ueyama, Tomomi Gotoh, Masataka Mori, Mitsuhiro Yokoyama

  Arginase catalyzes the hydrolysis of arginine to urea and ornithine. Urea is not only an important solute for concentrating urine but also inhibits Na-K-2Cl cotransport. To elucidate the roles of arginase in the development of salt-sensitive hypertension, we examined arginase activity and expression in the kidney and other organs of Dahl/Rapp salt-sensitive (SS) and salt-resistant (SR) rats before and after 4 weeks' administration of a 4% NaCl or control diet. At 4 weeks of age, arginase activity in the kidney was lower in SS rats than in SR rats. Kidney arginase activity was lower in SS rats than in SR rats at 8 weeks of age, and salt loading did not alter arginase activity. Arginase II (the dominant isoform in the kidney) mRNA and protein in the kidney of salt-loaded SS rats were also lower than those of salt-loaded SR rats. Arginase activities in the liver and cerebellum did not differ between SS and SR rats. To examine the effect of urea, the product of arginase reaction, on the development of hypertension, SS rats were given a 4% NaCl diet containing 5% kaolin or 5% urea. Six-week urea supplementation attenuated the development of hypertension in SS rats. These findings suggest that decreased arginase expression in the kidney may be at least partially responsible for the salt-sensitive hypertension in SS rats.

  May 2002, Hypertension research : official journal of the Japanese Society of Hypertension, 25(3) (3), 411 - 8, English, International magazine

  Scientific journal


• Local overexpression of monocyte chemoattractant protein-1 at vessel wall induces infiltration of macrophages and formation of atherosclerotic lesion: synergism with hypercholesterolemia.

  Masayuki Namiki, Seinosuke Kawashima, Tomoya Yamashita, Masanori Ozaki, Tetsuaki Hirase, Tatsuro Ishida, Nobutaka Inoue, Ken-ichi Hirata, Akihiro Matsukawa, Ryuichi Morishita, Yasufumi Kaneda, Mitsuhiro Yokoyama

  Monocyte/macrophage infiltration to the arterial wall is an initial step in atherosclerosis, and monocyte chemoattractant protein-1 (MCP-1) is thought to play a central role in the recruitment of these cells. In the present study, we examined the role of local expression of MCP-1 at the vessel wall in the initiation and development of atherosclerosis. We transfected the cDNA encoding rat MCP-1 into the vessel wall of the rabbit carotid artery with the use of the hemagglutinating virus of Japan (HVJ)-liposome method. The rabbits were divided into the following groups: (1) those fed normal chow and transfected with MCP-1-HVJ, (2) those fed a high cholesterol diet (1% cholesterol) and transfected with MCP-1-HVJ, and (3) those fed a high cholesterol diet and transfected with control-HVJ. Prescribed diets were started 2 weeks before transfection and were continued for another 2 weeks. In group 1, vascular lesion formation was not found, and anti-rabbit monocyte/macrophage antibody (RAM-11) staining for monocytes/macrophages was negative, although anti-rat MCP-1 antibody (R-17) staining for rat MCP-1 was positive mainly in endothelial cells. Cholesterol feeding increased plasma cholesterol levels to 1801+/-444 mg/dL in group 2. In group 2, all rabbits displayed neointimal formation with infiltration of RAM-11-positive cells, and a part of the lesion was also positive for Sudan III lipid staining. In group 3, hypercholesterolemia did not induce the infiltration of monocytes/macrophages and subsequent lesion formation in the vessel wall despite definite upregulation of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 on the endothelium. To initiate atherosclerotic changes, local MCP-1 overexpression at the vessel is not sufficient, and activation of other factors induced by hypercholesterolemia is required.

  Jan. 2002, Arteriosclerosis, thrombosis, and vascular biology, 22(1) (1), 115 - 20, English, International magazine

  Scientific journal


• Cloning of an Immunoglobulin Family Adhesion Molecule Selectively Expressed by Endothelial Cells

  Ken-Ichi Hirata, Tatsuro Ishida, Kalyani Penta, Mehrdad Rezaee, Eugene Yang, Jay Wohlgemuth, Thomas Quertermous

  May 2001, Journal of Biological Chemistry, 276(19) (19), 16223 - 16231, English

  [Refereed]

  Scientific journal


• Serotonin-induced hypercontraction through 5-hydroxytryptamine 1B receptors in atherosclerotic rabbit coronary arteries

  Tatsuro Ishida, Seinosuke Kawashima, Ken-Ichi Hirata, Tsuyoshi Sakoda, Yasushi Shimokawa, Yoichi Miwa, Nobutaka Inoue, Tomomi Ueyama, Masashi Shiomi, Hozuka Akita, Mitsuhiro Yokoyama

  Lippincott Williams and Wilkins, Mar. 2001, Circulation, 103(9) (9), 1289 - 1295, English

  [Refereed]

  Scientific journal


• Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy

  T Ueyama, S Kawashima, T Sakoda, Y Rikitake, T Ishida, M Kawai, T Yamashita, S Ishido, H Hotta, M Yokoyama

  Jun. 2000, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 32(6) (6), 947 - 960, English

  [Refereed]

  Scientific journal


• Regulated expression of endothelial cell-derived lipase

  Ken-Ichi Hirata, Tatsuro Ishida, Hidetsugu Matsushita, Phillip S. Tsao, Thomas Quertermous

  Academic Press Inc., May 2000, Biochemical and Biophysical Research Communications, 272(1) (1), 90 - 93, English

  [Refereed]

  Scientific journal


• Resistance to endotoxin shock in transgenic mice overexpressing endothelial nitric oxide synthase

  Tomoya Yamashita, Seinosuke Kawashima, Yoshitaka Ohashi, Masaori Ozaki, Tomomi Ueyama, Tatsuro Ishida, Nobutaka Inoue, Ken-Ichi Hirata, Hozuka Akita, Mitsuhiro Yokoyama

  Lippincott Williams and Wilkins, Feb. 2000, Circulation, 101(8) (8), 931 - 937, English

  [Refereed]

  Scientific journal


• T102C polymorphism of the serotonin (5-HT) 2A receptor gene in patients with non-fatal acute myocardial infarction

  Shinichiro Yamada, Hozuka Akita, Kenji Kanazawa, Tatsuro Ishida, Ken-Ichi Hirata, Keiichi Ito, Seinosuke Kawashima, Mitsuhiro Yokoyama

  2000, Atherosclerosis, 150(1) (1), 143 - 148, English

  [Refereed]

  Scientific journal


• Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase

  Yoshitaka Ohashi, Seinosuke Kawashima, Ken-Ichi Hirata, Tomoya Yamashita, Tatsuro Ishida, Nobutaka Inoue, Tsuyoshi Sakoda, Hiroki Kurihara, Yoshio Yazaki, Mitsuhiro Yokoyama

  The American Society for Clinical Investigation, Dec. 1998, Journal of Clinical Investigation, 102(12) (12), 2061 - 2071, English

  [Refereed]

  Scientific journal


• 5-HT(1Dβ) receptor mediates the supersensitivity of isolated coronary artery to serotonin in variant angina

  Tatsuro Ishida, Ken-Ichi Hirata, Tsuyoshi Sakoda, Kenji Kanazawa, Seinosuke Kawashima, Hozuka Akita, Mitsuhiro Yokoyama

  American College of Chest Physicians, 1998, Chest, 113(1) (1), 243 - 244, English

  [Refereed]

  Scientific journal


• Disparity between serotonin- and acetylcholine-provoked coronary artery spasm

  Kenji Kanazawa, Masakum Suematsu, Tatsuro Ishida, Ken-Ichi Hirata, Seixosuke Kawasihma, Hozuka Aktta, Mitsuhiro Yokoyama

  John Wiley and Sons Inc., 1997, Clinical Cardiology, 20(2) (2), 146 - 152, English

  [Refereed]

  Scientific journal

• 酸化ストレスに対するα-ケトグルタル酸の心筋細胞保護作用

  渡部 晃一, 杜 隆嗣, 西森 誠, 岡野 光真, 入野 康宏, 原 哲也, 篠原 正和, 小林 成美, 石田 達郎, 平田 健一

  (一社)日本心臓病学会, Sep. 2019, 日本心臓病学会学術集会抄録, 67回, P - 206, Japanese


• 日本人において血清トランス脂肪酸濃度の上昇は経皮的冠動脈インターベンション後の再血行再建術発生の独立したリスク因子となる

  尾下 寿彦, 杜 隆嗣, 篠原 正和, 森 健太, 入野 康宏, 長尾 学, 原 哲也, 大竹 寛雅, 石田 達郎, 平田 健一

  (一社)日本動脈硬化学会, Jul. 2019, 日本動脈硬化学会総会プログラム・抄録集, 51回, 2 - 3, Japanese


• HDL機能性の新しい指標であるコレステロール取り込み能とコレステロール排出能の冠動脈プラーク特性に関連した比較(Comparison of Cholesterol Uptake Capacity, a Novel Indicator for HDL-functionality, and Cholesterol Efflux Capacity in Association with Coronary Plaque Properties)

  尾下 寿彦, 杜 隆嗣, 岡野 光真, 渡部 晃一, 西森 誠, 永野 雄一朗, 原田 周, 村上 克洋, 桐山 真利亜, 吉川 景子, 三輪 桂子, 小林 成美, 篠原 正和, 原 哲也, 入野 康宏, 大竹 寛雅, 石田 達郎, 平田 健一

  (一社)日本循環器学会, Mar. 2019, 日本循環器学会学術集会抄録集, 83回, PJ100 - 3, English


• わが国におけるトランス脂肪酸の動脈硬化性疾患への影響

  Ishida Tatsuro

  Nov. 2018, Therapeutic Research, 39(11) (11), 905 - 906, Japanese

  [Invited]

  Introduction commerce magazine


• Cardioprotective Effects of High-Density Lipoprotein Beyond its Anti-Atherogenic Action

  Nagao M, Nakajima H, Ryuji T, Hirata Ken-ichi, Ishida Tatsuro

  Oct. 2018, J Atheroscler Thromb, 25(10) (10), 985 - 993, English, Domestic magazine

  [Refereed]

  Book review

  Link to Kobe Univ. Repository (Kernel)


• Development of markers for progression of coronary plaques using WHHLMI rabbits, an animal model of familial hypercholesterolemia

  Masashi Shiomi, Hiroaki Takeda, Yasuhiro Irino, Satoshi Yamada, Nobue Kuniyoshi, Yu Ying, Tomonari Koike, Yoshihiro Izumi, Masakazu Shinohara, Takeshi Bamba, Tatsuro Ishida

  Elsevier BV, Aug. 2018, Atherosclerosis, 275, e247 - e247


• 【脂質異常と冠動脈疾患】 基礎 脂質と血管リモデリング

  Hara Tetsuya, Ishida Tatsuro

  (株)メディカルレビュー社, Jul. 2018, Cardiac Practice, 29(2) (2), 97 - 101, Japanese

  Introduction commerce magazine


• HDL代謝異常症と動脈硬化

  Toh Ryuji, Ishida Tatsuro

  Jul. 2018, Heart View, 22(7) (7), 649 - 656, Japanese

  [Invited]

  Introduction commerce magazine


• 高血圧患者における食塩摂取量簡易評価方法の検討

  脇田久美子, 脇田久美子, 三ヶ尻礼子, 田渕聡子, 山西美沙, 山下弘子, 玉田萌子, 西田ひかる, 山本育子, 松田佳子, 松田佳子, 高橋路子, 高橋路子, 小川渉, 小川渉, 小林成美, 杜隆嗣, 石田達郎, 大瀬良知子, 栗原伸公

  2018, 日本静脈経腸栄養学会雑誌, 33(1) (1)


• Modulation of high-density lipoprotein function via cardiac rehabilitation

  Seimi Satomi-Kobayashi, Tatsuro Ishida

  Japan Atherosclerosis Society, 2018, Journal of Atherosclerosis and Thrombosis, 25(2) (2), 128 - 130, English, Domestic magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• 【家族性高コレステロール血症(FH)up to date】 FH治療の実際 FHヘテロ接合体の薬物治療 通常治療でここまでできる

  篠原正和, 石田達郎, Hirata Ken-ichi

  Nov. 2017, Modern Physician, 37(11号) (11号), 1167 - 1170, Japanese

  [Invited]

  Introduction commerce magazine


• Compensatory Accumulation of aHydroxybutyrate Accompanied by SCOT Downregulation in Failing Hearts

  Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Takeshige Mori, Tetsuya Hara, Tomoyuki Honjo, Seimi Satomi-Kobayasi, Toshiro Shinke, Hidekazu Tanaka, Tatsuro Ishida, Ken-ichi Hirata

  Nov. 2016, CIRCULATION, 134, English

  Summary international conference


• Cholesterol Uptake Capacity, a Novel Measure of High Density Lipoprotein Functionality for Coronary Risk Stratification

  Amane Harada, Ryuji Toh, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Takuya Kubo, Keiko Miwa, Yasuhiro Irino, Kenta Mori, Nobuaki Tanaka, Tatsuro Ishida, Ken-ichi Hirata

  Nov. 2016, CIRCULATION, 134, English

  Summary international conference


• De Novo Leukotriene B-4 Production From High-Density Lipoprotein (HDL) in Recurrent Cardiovascular Disease Patients Deteriorates Anti-Inflammatory Properties of HDL

  Shigeyasu Tsuda, Masakazu Shinohara, Toshihiko Oshita, Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Tetsuya Hara, Yasuhiro Irino, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata

  Nov. 2016, CIRCULATION, 134, English

  Summary international conference


• Impaired HDL uptake capacity which measure HDL functionality may associate with target lesion revascularization through provoking neoatherosclerosis formation after stent implantation

  Yuichiro Nagano, Hiromasa Otake, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Yasuhiro Irino, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Koji Kuroda, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Yoshinori Nagasawa, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Toshiro Shinke, Tatsuro Ishida, Ryuji Toh, Ken-Ichi Hirata

  Nov. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B136 - B136, English

  [Refereed]

  Summary international conference


• 【機能性脂質・脂肪酸の多彩な生理活性と病態形成】 トランス脂肪酸と血管医学

  篠原正和, Ishida Tatsuro, Hirata Ken-ichi

  メディカルレビュー社, Jul. 2016, 血管医学, 17(2号) (2号), 183 - 190, Japanese

  [Invited]

  Introduction commerce magazine


• 高比重リポ蛋白(HDL)の抗炎症効果はリン脂質構成に依存する

  田中 伸明, 入野 康弘, 篠原 正和, 尾下 寿彦, 津田 成康, 長尾 学, 森 健茂, 森 健太, 中島 英人, 原 哲也, 杜 隆嗣, 石田 達郎, 平田 健一

  (一社)日本動脈硬化学会, Jun. 2016, 日本動脈硬化学会総会プログラム・抄録集, 48回, 242 - 242, Japanese


• THE IMPACT OF SERUM TRANS FATTY ACIDS CONCENTRATION ON PLAQUE VULNERABILITY IN PATIENTS WITH CORONARY ARTERY DISEASE UNDER MANAGEMENT OF CONVENTIONAL RISK FACTORS: ASSESSMENT VIA OPTICAL COHERENCE TOMOGRAPHY

  Yoshinori Nagasawa, Toshiro Shinke, Ryuji Toh, Hiromasa Otake, Tomofumi Takaya, Takayoshi Toba, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Daiji Kashiwagi, Koji Kuroda, Yuto Shinkura, Natsuko Tahara, Hiroyuki Yamamoto, Yoshiro Tsukiyama, Kenichi Yanaka, Yuichiro Nagano, Tatsuro Ishida, Ken-Ichi Hirata

  Apr. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 361 - 361, English

  Summary international conference


• 【脂質異常症の臨床 見落としていませんか】 知っておくべき病態生理と診療の進め方 典型例から学ぶ 高HDL-C血症

  篠原正和, Ishida Tatsuro

  Apr. 2016, Medical Practice, 33(4号) (4号), 575 - 580, Japanese

  [Invited]

  Introduction scientific journal


• 高HDL-C血症

  篠原正和, Ishida Tatsuro

  2016, Medical Practice, Japanese

  [Invited]

  Introduction commerce magazine


• HDL 定量検査から機能検査へ HDLの抗炎症能の分子機序と評価方法

  田中伸明, Ishida Tatsuro

  日本臨床検査医学会 ; 1953-, Jan. 2016, 臨床病理, 64(1) (1), 49 - 56, Japanese

  Introduction scientific journal


• Targeted Disruption of JCAD/KIAA1462, a Coronary Artery Disease-associated Gene Product, Inhibits Angiogenic Processes in Vitro and in Vivo

  Tetsuya Hara, Tomoko Monguchi, Masaya Akashi, Noriko Iwamoto, Kenta Mori, Ryuji Toh, Yasuhiro Irino, Masakazu Shinohara, Mikio Furuse, Tatsuro Ishida, Ken-ichi Hirata

  Nov. 2015, CIRCULATION, 132, English

  Summary international conference


• 【原発性脂質異常症:疾患概念の整理と最近の進歩】 原発性低脂血症 家族性低HDLコレステロール血症の分子機構

  Hara Tetsuya, Ishida Tatsuro

  Aug. 2015, Pharma Medica, 33(8号) (8号), 57 - 60, Japanese

  [Refereed]

  Introduction commerce magazine


• 【LDL/HDLコレステロールを標的とした動脈硬化症の新しい治療ストラテジー】 機能不全HDLに対する治療戦略

  入野康宏, Ishida Tatsuro, Toh Ryuji

  Apr. 2015, 血管医学, 16(1) (1), 53 - 60, Japanese

  [Invited]

  Introduction commerce magazine


• EX VIVO SIMULATION OF THE IMMUNE RESPONSE AGAINST OXDIZED LOW-DENSITY LIPOPROTEIN AS ANEW RISK STRATIFICATION IN CORONARY ARTERY DISEASE

  Tomoyuki Honjo, Ryuji Toh, Nobuaki Tanaka, Masato Mitsuhashi, Kenta Mori, Takeshige Mori, Manabu Nagao, Tatsuro Ishida, Ken-ichi Hirata

  Mar. 2015, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65(10) (10), A1604 - A1604, English

  Summary international conference


• Oral Administration of Eicosapentaenoic Acid Ameliorates Anti-inflammatory Functions of High-Density Lipoprotein in Dyslipidemic Patients

  Nobuaki Tanaka, Tatsuro Ishida, Manabu Nagao, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kenta Mori, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Ryuji Toh, Ken-ichi Hirata

  Nov. 2014, CIRCULATION, 130, English

  Summary international conference


• 2-Aminobutyric Acid, a Potential Indicator of Oxidative Stress in Failing Hearts

  Ryuji Toh, Yasuhiro Irino, Takeshige Mori, Manabu Nagao, Tomoyuki Honjo, Seimi Satomi-Kobayashi, Tatsuro Ishida, Okiko Miyata, Ken-Ichi Hirata

  Oct. 2014, JOURNAL OF CARDIAC FAILURE, 20(10) (10), S186 - S186, English

  Summary international conference


• GCMSを用いた心不全バイオマーカー探索

  入野 康宏, 杜 隆嗣, 森 健茂, 長尾 学, 本庄 友行, 小林 成美, 新家 俊郎, Ishida Tatsuro, 宮田 興子, Hirata Ken-ichi

  (一社)日本医用マススペクトル学会, Sep. 2014, JSBMS Letters, 39(Suppl.) (Suppl.), 66 - 66, Japanese

  Meeting report


• 【HDL機能と病態・創薬】 HDLを標的とした動脈硬化性疾患治療の現状と未来 endothelial lipase

  安田知行, Ishida Tatsuro

  Jul. 2014, The Lipid, 25(3) (3), 274 - 281, Japanese

  [Invited]

  Introduction commerce magazine


• 高比重リポ蛋白による心筋細胞保護作用の検討

  中島 英人, Ishida Tatsuro, Hirata Ken-ichi

  Jun. 2014, 日本動脈硬化学会総会プログラム・抄録集, (46回) (46回), 241, Japanese

  Meeting report


• 【栄養素から考える心血管病】 飽和脂肪酸・コレステロールと心血管病

  中島 英人, Ishida Tatsuro, Hirata Ken-ichi

  科学評論社, Jun. 2014, 循環器内科, 75(6号) (6号), 563 - 570, Japanese

  Introduction commerce magazine


• 機能不全HDLの簡便な臨床評価法としての血清MPO/PON1比測定の有用性

  杜 隆嗣, Ishida Tatsuro, 西村 邦宏, 平田 健一

  Feb. 2014, 日本内科学会雑誌, 103(Suppl.) (Suppl.), 149, Japanese

  Meeting report


• 【リパーゼの臨床的意義】 脂質代謝、動脈硬化における機能と臨床的意義 血管内皮リパーゼの炎症と血清HDL代謝における役割

  Ishida Tatsuro, Hirata Ken-ichi

  Oct. 2013, The Lipid, 24(4号) (4号), 353 - 362, Japanese

  [Invited]

  Introduction commerce magazine


• 【脂質異常症-基礎・臨床研究の最新知見-】 脂質異常症による粥状硬化発症進展機序

  Ishida Tatsuro, Hirata Ken-ichi

  Jun. 2013, 日本臨床, 71(増刊3 脂質異常症) (増刊3 脂質異常症), 21 - 28, Japanese

  [Invited]

  Introduction commerce magazine


• 【HDLの多面的作用とその異常-善玉HDLと悪玉HDL】 HDL結合蛋白とその作用

  中島 英人, Ishida Tatsuro

  医歯薬出版, May 2013, 医学のあゆみ, 245(6号) (6号), 496 - 500, Japanese

  Introduction scientific journal


• PITAVASTATIN INCREASES HDL PARTICLES WITH PRESERVED ANTI-ATHEROSCLEROTIC PROPERTIES IN DYSLIPIDEMIC PATIENTS

  Tomoyuki Yasuda, Tatsuro Ishida, Maki Miyamoto-Sasaki, Tomoko Monguchi, Ken-ichi Hirata

  Mar. 2013, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 61(10) (10), E2033 - E2033, English

  Summary international conference


• Postprandial Increases of Circulating Mass of Endothelial Lipase Impact Plasma High-Density Lipoprotein-Cholesterol Concentrations

  Tatsuro Ishida, Kenta Mori, Tomoyuki Yasuda, Ken-ichi Hirata, Kazuya Miyashita, Noriaki Kinoshita, Katsuyuki Nakajima, Kimber Stanhope, Peter J. Havel

  Nov. 2012, CIRCULATION, 126(21) (21), English

  Summary international conference


• Increase in Exogenous Lipoproteins Characterized by Apolipoprotein B48 and Cholesterol Absorption/Synthesis Markers Represents Residual Risks for Coronary Artery Disease during Intensive LDL-Lowering Therapy

  Kenta Mori, Tatsuro Ishida, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Minoru Hasokawa, Hideto Nakajima, Yoko Haraguchi, Li Sun, Tomoyuki Yasuda, Ryuji Toh, Ken-ichi Hirata

  Nov. 2012, CIRCULATION, 126(21) (21), English

  Summary international conference


• Endothelial Lipase in the Heart Modulates Pressure Overload-Induced Heart Failure through Fatty Acid Utilization

  Hideto Nakajima, Tatsuro Ishida, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Kenta Mori, Minoru Hasokawa, Yoko Haraguchi, Tomoyuki Yasuda, Li Sun, Ryuji Toh, Seimi Kobayashi, Ken-Ichi Hirata

  Nov. 2012, CIRCULATION, 126(21) (21), English

  Summary international conference


• 糖尿病合併症と炎症 糖尿病性動脈硬化における脂質異常の役割の新知見

  Ishida Tatsuro, Hirata Kenichi

  Jul. 2012, 糖尿病合併症, 26(1号) (1号), 28 - 30, Japanese

  [Invited]

  Introduction scientific journal


• 急性心筋梗塞症のメカニズムに迫る臨床病理と動物モデルから動脈硬化性プラーク不安定化・破綻の原因を探る 冠動脈病変破綻におけるMMP陽性マクロファージとスパズムの役割

  Shiomi Masashi, Ishida Tatsuro, Hirata Kenichi, Ito Takashi

  Jul. 2012, 日本動脈硬化学会総会プログラム・抄録集, (44回) (44回), 146, Japanese

  [Refereed]

  Meeting report


• 【心臓・血管リモデリングからみた循環器疾患】 脂質異常症による血管リモデリングと粥状硬化の発症機序

  Ishida Tatsuro, Hirata Kenichi

  科学評論社, Jul. 2012, 循環器内科, 72(1号) (1号), 35 - 42, Japanese

  [Refereed]

  Introduction scientific journal


• 血管内皮リパーゼの血中濃度と活性が血清HDL-C値と冠動脈硬化に及ぼす影響の検討

  Ishida Tatsuro

  Mar. 2012, 循環医学研究年報, (4号) (4号), 4 - 5, Japanese

  Meeting report


• The impact of paraoxonase-1 activity on the incidence of intra-stent thrombus after drug-eluting stent implantation in the Japanese CYP2C19*2 carriers receiving clopidogrel

  Ryo Nishio, Junya Shite, Toshiro Shinke, Hiromasa Otake, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Yoko Haraguchi, Tatsuro Ishida

  Nov. 2011, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58(20) (20), B49 - B49, English

  Summary international conference


• Fasting Apolipoprotein B48 is a Novel Marker for Residual Risks in Coronary Artery Disease During Intensive LDL-Lowering Therapy

  Kenta Mori, Tatsuro Ishida, Maki Sasaki, Kensuke Kondo, Minoru Hasokawa, Hideto Nakajima, Yoko Haraguchi, Li Sun, Ryuji Toh, Tomoyuki Yasuda, Masakazu Shinohara, Kunihiro Nishimura, Ken-Ichi Hirata

  Nov. 2011, CIRCULATION, 124(21) (21), English

  Summary international conference


• 心房細動および心房粗動に対するカテーテルアブレーション後に心室細動を発症した一例

  杉崎陽一郎, 藤原竜童, 今西純一, 山下智也, 武居明日美, 石田達郎, 吉田明弘, 志手淳也, 川合宏哉, 平田健一

  2011, 日本循環器学会近畿地方会(Web), 112th


• 【動脈硬化を診る リスク評価と病態の検査】 脂質・リポ蛋白の検査 リポ蛋白の調節因子 血管内皮リパーゼ

  Ishida Tatsuro

  Dec. 2010, Medical Technology, 38巻, 13号, pp. 1361-1365, Japanese

  Introduction scientific journal


• Serum Myeloperoxidase/Paraoxonase 1 Ratio Is an Independent Predictor for Repeat Revascularization After Percutaneous Coronary Intervention

  Yoko Haraguchi, Ryuji Toh, Minoru Hasokawa, Hideto Nakajima, Tomoyuki Honjo, Kazunori Otsui, Kunihiro Nishimura, Tatsuro Ishida, Ken-ichi Hirata

  Nov. 2010, CIRCULATION, 122(21) (21), English

  Summary international conference


• Update on the Role of Endothelial Lipase in High-Density Lipoprotein Metabolism, Reverse Cholesterol Transport, and Atherosclerosis

  Tomoyuki Yasuda, Tatsuro Ishida, Daniel J. Rader

  Nov. 2010, CIRCULATION JOURNAL, 74(11) (11), 2263 - 2270, English

  Book review


• 【コレステロール吸収・リポ蛋白代謝研究から新たな脂質異常症治療へ】 HDL代謝における血管内皮リパーゼの役割と治療への応用

  Ishida Tatsuro, Hirata Kenichi

  Aug. 2010, 医学のあゆみ, 234巻, 7-8, pp. 775-780, Japanese

  Introduction scientific journal


• Endothelial Lipase Reduces Lesion Formation in Mouse Model of Vascular Remodeling via Modulating HDL levels

  Li Sun, Tatsuro Ishida, Yoshiyuki Rikitake, Ken-Ichi Hirata

  Jul. 2010, CIRCULATION, 122(2) (2), E291 - E291, English

  Summary international conference


• 【新しい脂質代謝改善薬の可能性を探る 動脈硬化性疾患治療薬】 新しい脂質代謝/動脈硬化改善薬 多価不飽和脂肪酸製剤

  Ishida Tatsuro, Hirata Kenichi

  May 2010, Mebio, 27巻, 5号, pp. 76-86, Japanese

  Introduction scientific journal


• 血管内皮リパーゼの臨床的意義 (代謝) -- (臨床分野での進歩)

  石田 達郎, 平田 健一

  中外医学社, 2010, Annual review. 糖尿病・代謝・内分泌, 2010, 152 - 159, Japanese


• Inactivation of Endothelial Lipase Increases Anti-inflammatory HDL Particles

  Tetsuya Hara, Tatsuro Ishida, Yoko Kojima, Ken-ichi Hirata

  Nov. 2009, CIRCULATION, 120(18) (18), S469 - S469, English

  Summary international conference


• 【HDLを再考する】 HDLの異化の制御のCardiovascular Riskにおける役割を考える

  Ishida Tatsuro, Hirata Kenichi

  先端医学社, Apr. 2009, Vascular Medicine, 5巻, 2号, pp. 127-134(2) (2), 127 - 134, Japanese

  Introduction scientific journal


• OE-358 Inactivation of Endothelial Lipase Increases "Good Cholesterol"(OE61,Lipid Disorders (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  Hara Tetsuya, Ishida Tatsuro, Kojima Yoko, Hirata Kenichi

  Japanese Circulation Society, 01 Mar. 2009, Circulation journal : official journal of the Japanese Circulation Society, 73, 265 - 265, English


• Effect of Pitavastatin on Serum Concentrations of Endothelial Lipase and High-Density Lipoprotein Cholesterol in Humans

  Li Sun, Tatsuro Ishida, Kojima Yoko, Tomoyuki Yasuda, Akira Fukuda, Fumie Kureha, Kenichi Hirata

  Oct. 2008, CIRCULATION, 118(18) (18), S370 - S370, English

  Summary international conference


• Targeted Inactivation of Receptor for Advanced Glycation Products Reduced Oxidative LDL-Induced Inflammation and Atherosclerosis in Non-Diabetic LDL Receptor-/- Mice

  Li Sun, Tatsuro Ishida, Masamitsu Kuriyama, Tomoyoki Yasuda, Tetsuya Hara, Kenichi Hirata, Yoshitake Hayashi

  Oct. 2008, CIRCULATION, 118(18) (18), S481 - S481, English

  Summary international conference


• Role of Endothelial Cell-Selective Adhesion Molecule in the Progression of Atherosclerosis

  Michihiko Inoue, Tatsuro Ishida, Tetsuya Hara, Cangara M. Husni, Li Sun, Ken-ichi Hirata

  Oct. 2008, CIRCULATION, 118(18) (18), S502 - S502, English

  Summary international conference


• PE-219 Endothelial Lipase is a Key Molecule of Postprandial Hypertriglycemia in Mice(Metabolism/Biochemistry/Energetics(02)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Fukuda Akira, Ishida Tatsuro, Yasuda Tomoyuki, Hirata Kenichi

  Japanese Circulation Society, 01 Mar. 2008, Circulation journal : official journal of the Japanese Circulation Society, 72, 414 - 415, English


• PJ-343 High Glucose Stimulation Reduced Endothelial Cell-Selective Adhesion Molecule (ESAM) Expression : A Potential Role in Albuminuria in Diabetic Microangiopathy(Kidney/Renal circulation(06)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Hara Tetsuya, Ishida Tatsuro, Yasuda Tomoyuki, Okada Takeaki, Fukuda Akira, Inoue Michihiko, Kureha Fumie, Hirata Kenichi

  Japanese Circulation Society, 01 Mar. 2008, Circulation journal : official journal of the Japanese Circulation Society, 72, 597 - 598, English


• OE-175 Role of Endothelial Cell-selective Adhesion Molecule (ESAM) in Tumor Angiogenesis and Metastasis(Molecular biology, vascular(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Cangara Husni, Ishida Tatsuro, Kuriyama Masamitsu, Hara Tetsuya, Inoue Michihiko, Hayashi Yoshitake, Hirata Kenichi

  Japanese Circulation Society, 01 Mar. 2008, Circulation journal : official journal of the Japanese Circulation Society, 72, 224 - 224, English


• PE-155 RAGE Deficiency Inhibit the Atherosclerosis Progression in non diabetic Low-Density Lipoprotein Receptor Knockout Mice(Atherosclerosis, basic(04)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Sun Li, Ishida Tatsuro, Kuriyama Masamitsu, Yasuda Tomoyoki, Hara Tetsuya, Hayashi Yoshitake, Hirata Kenichi

  Japanese Circulation Society, 01 Mar. 2008, Circulation journal : official journal of the Japanese Circulation Society, 72, 399 - 399, English


• OE-207 Endothelial lipase selectively regulates HDL metabolism in rabbits(Lipid disorders(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Yasuda Tomoyuki, Ishida Tatsuro, Okada Takeaki, Fukuda Akira, Hara Tetsuya, Inoue Michihiko, Ohno Fumie, Hirata Kenichi

  Japanese Circulation Society, 01 Mar. 2008, Circulation journal : official journal of the Japanese Circulation Society, 72, 232 - 232, English


• 【脂質代謝異常症診療の新展開】 期待される治療標的 血管内皮リパーゼを分子標的としたHDL増加療法の可能性

  Ishida Tatsuro, Hirata Kenichi

  医学の世界社, Mar. 2008, ホルモンと臨床, 56巻, 3号, pp. 293-300(3) (3), 293 - 300, Japanese

  Introduction scientific journal


• 【脂質異常症の臨床 ガイドラインの日常診療への応用】 脂質異常症の薬物療法オーバービュー フィブラート、EPAのエビデンス

  Ishida Tatsuro, Hirata Kenichi

  Mar. 2008, Modern Physician, 28巻, 3号, pp. 383-387, Japanese

  Introduction scientific journal


• Overexpression of endothelial lipase in the liver promotes the clearance of plasma lipids but accelerates liver steatosis in a mouse model of metabolic syndrome

  Tomoyuki Yasuda, Tatsuro Ishida, Yoko Kojima, Hanayo Tanaka, Takeaki Okada, Akira Fukuda, Tetsuya Hara, Michihiko Inoue, Ken-ichi Hirata

  Oct. 2007, CIRCULATION, 116(16) (16), 240 - 240, English

  Summary international conference


• PE-457 Endothelial Lipase is Increased by Inflammation and Promotes LDL Uptake in Macrophages(Infection/Inflammation/Immunity-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Yasuda Tomoyuki, Hirata Kenichi, Ishida Tatsuro, Kojima Yoko, Tanaka Hanayo, Okada Takeaki, Taira Kazuki, Yokoyama Mitsuhiro

  Japanese Circulation Society, 01 Mar. 2007, Circulation journal : official journal of the Japanese Circulation Society, 71, 439 - 439, English


• FRS-042 Targeted Inactivation of Endothelial Cell-selective Adhesion Molecule Inhibits Susceptibility to Atherosclerosis in Apoprotein-E-deficient Mice(Vascular Biology in Endothelial Cells (basic), The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Taira Kazuki, Hirata Kenichi, Ishida Tatsuro, Kojima Yoko, Yasuda Tomoyuki, Okada Takeaki, Tanaka Hanayo, Yokoyama Mitsuhiro

  Japanese Circulation Society, 01 Mar. 2007, Circulation journal : official journal of the Japanese Circulation Society, 71, 126 - 126, English


• OE-113 Over-expression of Endothelial Lipase in the Liver Exacerbated Hepatic Steatosis in a Mouse Model of Metabolic Syndrome(Diabetes/Obesity/Metabolic syndrome-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Yasuda Tomoyuki, Hirata Kenichi, Ishida Tatsuro, Kojima Yoko, Tanaka Hanayo, Okada Takeaki, Taira Kazuki, Fukuda Akira, Yokoyama Mitsuhiro

  Japanese Circulation Society, 01 Mar. 2007, Circulation journal : official journal of the Japanese Circulation Society, 71, 179 - 179, English


• PJ-666 EL Overexpression in the Vessel Wall doesn't Affect Atherosclerotic Lesion Formation in ApoE-KO mice(Molecular biology, vascular-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Okada Takeaki, Hirata Kenichi, Ishida Tatsuro, Kojima Yoko, Yasuda Tomoyuki, Tanaka Hanayo, Taira Kazuki, Fukuda Akira

  Japanese Circulation Society, 01 Mar. 2007, Circulation journal : official journal of the Japanese Circulation Society, 71, 638 - 638, English


• 3 The Role of Endothelial Lipase in HDL Metabolism and Atherosclerosis : A New Therapeutic Target for Raising HDL-Cholesterol(Hypoalphalipoproteinemia, Its Pathogenesis and Treatments, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Hirata Ken-ichi, Ishida Tatsuro, Yokoyama Mitsuhiro

  Japanese Circulation Society, 01 Mar. 2007, Circulation journal : official journal of the Japanese Circulation Society, 71, 65 - 65, English


• OE-058 Endothelial Lipase is Responsible for the Low Selrum HDL Level in the Chemically Induced Murine Model of Hyperlipidemia(Lipid disorders-1 (H) OE10,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

  Tanaka Hanayo, Hirata Ken-ichi, Ishida Tatsuro, Kojima Yoko, Yasuda Tomoyuki, Okada Takeaki, Taira Kazuki, Yokoyama Mitsuhiro

  Japanese Circulation Society, 01 Mar. 2006, Circulation journal : official journal of the Japanese Circulation Society, 70, 163 - 163, English


• OE-076 Endothelial Lipase-Deficient Mice are Protected Against Lipopolysaccharide-Induced Cardiac Inflammation and Left Ventricular Dysfunction(Infection/Inflammation/Immunity-1 (H) OE13,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

  Kojima Yoko, Hirata Kenichi, Ishida Tatsuro, Yasuda Tomoyuki, Okada Takeaki, Tanaka Hanayo, Taira Kazuki, Yokoyama Mitsuhiro

  Japanese Circulation Society, 01 Mar. 2006, Circulation journal : official journal of the Japanese Circulation Society, 70, 167 - 167, English


• PJ-241 A Sandwich Enzyme-linked Immunosorbent Assay for Human Endothelial Lipase Concentration(Lipid disorders-3 (H) PJ41,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

  Kojima Yoko, Hirata Kenichi, Ishida Tatsuro, Yasuda Tomoyuki, Okada Takeaki, Tanaka Hanayo, Taira Kazuki, Yokoyama Mitsuhiro

  Japanese Circulation Society, 01 Mar. 2006, Circulation journal : official journal of the Japanese Circulation Society, 70, 549 - 549, English


• Xenogenic smooth muscle cell immunization reduces neointimal formation in balloon-injured rabbit carotid arteries

  M Shinohara, S Kawashima, T Yamashita, T Takaya, R Toh, T Ishida, T Ueyama, N Inoue, KI Hirata, M Yokoyama

  Oct. 2005, CIRCULATION, 112(17) (17), U225 - U225, English

  Summary international conference


• 【女性における心血管疾患】 Cardiac Syndrome Xの病態の把握と治療

  児島陽子, HIRATA, Kenichi, ISHIDA, Tatsuro, YOKOYAMA, Mitsuhiro

  Oct. 2005, Cardiac Practice, 16巻, 4号, pp.381-386, Japanese

  Introduction scientific journal


• Targeted Disruption of Endothelial Lipase Reduced Susceptibility to Mortality in Endotoxin Shock(Infection/Inflammation/Immunity 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Kojima Yoko, Hirata Kenichi, Ishida Tatsuro, Okada Takeaki, Tanaka Hanayo, Yokoyama Mitsuhiro

  Japanese Circulation Society, 01 Mar. 2005, Circulation journal : official journal of the Japanese Circulation Society, 69, 207 - 207, English


• Endothelial Lipase Overexpression Accelerates Lesion Formation in Mouse Model of Vascular Remodeling (Molecular Biology, Vascular 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Okada Takeaki, Hirata Kenichi, Ishida Tatsuro, Kojima Yoko, Tanaka Hanayo, Taira Kazuki, Yokoyama Mitsuhiro

  Japanese Circulation Society, 01 Mar. 2005, Circulation journal : official journal of the Japanese Circulation Society, 69, 632 - 632, English


• Targeted Inactivation of Endothelial Lipase Reduced Atherosclerosis in Apolipoprotein-E Deficient Mice(Atherosclerosis, Basic 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Ishida Tatsuro, Hirata Kenichi, Kojima Yoko, Yamashita Tomoya, Tanaka Hanayo, Okada Takeaki, Quertermous Thomas, Yokoyama Mitsuhiro

  Japanese Circulation Society, 01 Mar. 2005, Circulation journal : official journal of the Japanese Circulation Society, 69, 260 - 260, English


• OJ-064 Identification of non-secreted endothelial cell-derived lipase (EDL) isoforms in human endothelial cells(Lipid Disorders 1 (H) : OJ8)(Oral Presentation (Japanese))

  Ishida Tatsuro, Hirata Kenichi, Kojima Yoko, Quertermous Thomas

  Japanese Circulation Society, 01 Mar. 2004, Circulation journal : official journal of the Japanese Circulation Society, 68, 246 - 246, English


• 【循環器疾患における最近のメガトライアル】 高脂血症・動脈硬化

  ISHIDA, Tatsuro, HIRATA, Kenichi, YOKOYAMA, Mitsuhiro

  Jan. 2004, Cardiac Practice, 15巻, 1号, pp. 23-32, Japanese

  Introduction scientific journal


• 【循環器疾患治療に必要な薬の知識】 抗狭心症薬

  ISHIDA, Tatsuro, YOKOYAMA, Mitsuhiro

  メディカ出版, Aug. 2003, ハートナーシング, 16巻, 8号, pp. 800-808(8) (8), 821 - 827, Japanese

  Introduction scientific journal


• Targeted Disruption and Overexpression of Endothelial Cell-Derived Lipase Modulates Plasma HDL and LDL Cholesterol Levels

  Ishida Tatsuro, Hirata Ken-ichi, Choi Sungshin, Cooper Allen, Quertermous Thomas, Yokoyama Mitsuhiro

  Japanese Circulation Society, 01 Mar. 2003, Circulation journal : official journal of the Japanese Circulation Society, 67, 627 - 628, English


• Role of Endothelial Cell-Derived Lipase in Monocyte Adhesion to Endothelial Cells

  Shimokawa Yasushi, Hirata Ken-ichi, Kojima Yoko, Iwai Kenji, Ishida Tatsuro, Hirase Tetsuaki, Inoue Nobutaka, Kawashima Seinosuke, Yokoyama Mitsuhiro

  Japanese Circulation Society, 01 Mar. 2003, Circulation journal : official journal of the Japanese Circulation Society, 67, 220 - 220, English


• Inflammatory response induces the expression of endothelial cell-derived lipase

  Y Kojima, Y Shimokawa, Y Rikitake, K Iwai, N Inoue, T Ishida, K Hirata

  Nov. 2002, CIRCULATION, 106(19) (19), 123 - 123, English

  Summary international conference


• Endothelial lipase: A new lipase on the block

  Sungshin Y. Choi, Ken-Ichi Hirata, Tatsuro Ishida, Thomas Quertermous, Allen D. Cooper

  01 Nov. 2002, Journal of Lipid Research, 43(11) (11), 1763 - 1769, English

  Book review


• Molecular cloning and expression analysis of rat endothelial cell-derived lipase

  Y Shimokawa, K Hirata, S Takeuchi, Y Rikitake, K Iwai, Y Kojima, N Inoue, S Kawashima, T Ishida, T Quertermous, M Yokoyama

  Apr. 2002, CIRCULATION, 105(14) (14), E105 - E105, English

  Summary international conference


• Lysophosphatidylcholine increases the secretion of matrix metalloproteinase 2 through the activation of NADH/NADPH oxidase in cultured aortic endothelial cells

  Nobutaka Inoue, Saori Takeshita, Dayaun Gao, Tatsuro Ishida, Seinosuke Kawashima, Hozuka Akita, Riichi Tawa, Hiromu Sakurai, Mitsuhiro Yokoyama

  2001, Atherosclerosis, 155(1) (1), 45 - 52, English


• P172 動脈硬化血管における血管内皮由来リパーゼ(EDL)の発現

  安積 啓, 平田 健一, 竹内 重人, 力武 良行, 井上 信孝, 川嶋 成乃亮, 横山 光宏, 石田 達郎, Thomas Quertermous, 林 祥剛, 伊東 宏

  社団法人日本循環器学会, 01 Mar. 2000, Japanese circulation journal, 64, 502 - 502, Japanese


• 0511 イムノグロブリンスーパーファミリーに属する血管内皮細胞特異的接着分子(ESAM)のクローニングと機能解析

  平田 健一, 石田 達郎, THOMAS QUERTERMOUS

  社団法人日本循環器学会, 01 Mar. 2000, Japanese circulation journal, 64, 313 - 313, Japanese


• Resistance to endotoxin shack in transgenic mice overexpressing endothelial nitric oxide synthase

  T Yamashita, S Kawashima, M Ozaki, Y Ohashi, T Ishida, N Inoue, K Hirata, M Yokoyama

  Nov. 1999, CIRCULATION, 100(18) (18), 113 - 113, English

  Summary international conference


• Nitric oxide overproduced by endothelial cells prevents vascular remodeling in the mouse carotid artery

  T Yamashita, S Kawashima, M Ozaki, Y Ohashi, S Takeuchi, T Ishida, N Inoue

  Nov. 1999, CIRCULATION, 100(18) (18), 3 - 3, English

  Summary international conference


• 0591 内皮型NO合成酵素過剰発現マウスでのNOに対する血管弛緩反応低下の機序

  山下 智也, 川嶋 成乃亮, 大橋 佳隆, 尾崎 正憲, 石田 達郎, 井上 信孝, 横山 光宏

  社団法人日本循環器学会, 01 Mar. 1999, Japanese circulation journal, 63(1) (1), 297 - 297, Japanese


• 0413 内皮型一酸化窒素合成酵素(eNOS)過剰発現マウスにおけるイソプロテレノール負荷による心肥大作用の減弱

  尾崎 正憲, 川嶋 成乃亮, 大橋 佳隆, 山下 智也, 平岡 栄治, 上山 知己, 石田 達郎, 井上 信孝, 横山 光宏

  社団法人日本循環器学会, 01 Mar. 1999, Japanese circulation journal, 63(1) (1), 251 - 251, Japanese


• 0923 内皮型NO合成酵素過剰発現マウスはエンドトキシンショックに抵抗性を示す

  山下 智也, 川嶋 成乃亮, 大橋 佳隆, 尾崎 正憲, 石田 達郎, 井上 信孝, 横山 光宏

  社団法人日本循環器学会, 01 Mar. 1999, Japanese circulation journal, 63(1) (1), 381 - 381, Japanese


• 0918 マウス頚動脈結紮内膜肥厚モデルにおける内皮型NO合成酵素過剰発現の影響

  山下 智也, 川嶋 成乃亮, 大橋 佳隆, 尾崎 正憲, 安積 啓, 石田 達郎, 井上 信孝, 横山 光宏

  社団法人日本循環器学会, 01 Mar. 1999, Japanese circulation journal, 63(1) (1), 380 - 380, Japanese


• Extracellular signal-regulated kinase(ERK)の活性化は心筋細胞肥大を誘導する 組換えアデノウイルスを用いた検討

  上山 知己, 川嶋 成乃亮, 力武 良行, 佐古田 剛, 石田 達郎, 岡田 美樹, 並木 雅行, 横山 光宏

  (一社)日本循環器学会, Mar. 1999, Japanese Circulation Journal, 63(Suppl.I) (Suppl.I), 252 - 252, Japanese


• Endothelin-1 activates p38 mitogen-activated protein kinase via endothelin-A receptor in rat myocardial cells

  Tomomi Ueyama, Seinosuke Kawashima, Tsuyoshi Sakoda, Yoshiyuki Rikitake, Tatsuro Ishida, Miki Kawai, Masayuki Namiki, Mitsuhiro Yokoyama

  1999, Molecular and Cellular Biochemistry, 199(1-2) (1-2), 119 - 124, English


• Identification of mRNA for 5-HT1 and 5-HT2 receptor subtypes in human coronary arteries

  ISHIDA T

  1999, Cardiovasc Res, 41, 267 - 274


• Reduced relaxations to NO/cGMP-mediated vasodilators in transgenic mice overexpressing endothelial nitric oxide synthase

  T Yamashita, Y Ohashi, S Kawashima, M Ozaki, T Ishida, T Sakoda, N Inoue, K Hirata, M Yokoyama

  Oct. 1998, CIRCULATION, 98(17) (17), 44 - 44, English

  Summary international conference


• NITRIC OXIDE IS PRODUCED VIA 5-HT_1B AND 5-HT_2B RECEPTOR ACTIVATION IN HUMAN CORONARY ARTERY ENDOTHELIAL CELLS

  Ishida Tatsuro, Kawashima Seinosuke, Hirata Ken-ichi, Yokoyama Mitsuhiro

  The aim of this study is to clarify the serotonin (5-HT) receptor subtypes responsible for 5-HT-induced nitric oxide (NO) production in cultured human coronary artery endothelial cells (HCAECs). Reverse transcription-polymerase chain reactions revealed that HCAECs possessed only 5-HT1B and 5-HT2B receptor mRNAs. 5-HT (0.001-10 mumol/L) induced nitrite production from HCAEC. A selective 5-HT1B/1D agonist sumatriptan (0.01-10 mumol/L) caused nitrite production. A selective 5-HT2 agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI, 0.01-10 mumol/L) also mimicked the effect of 5-HT. The 5-HT-induced nitrite production was completely inhibited by the nonselective 5-HT1/2 antagonist methiothepin (0.1 mumol/L), but not by the 5-HT2A/2C antagonist ketanserin (0.1 mumol/L). Each of these agonists evoked the elevation of intracellular Ca2+ concentration in HCAECs. These findings suggest that 5-HT-induced NO production is mediated by both of 5-HT1B and 5-HT2B receptor activation in HCAECs. Thus, the 5-HT-evoked endothelium-dependent relaxation of human coronary arteries in vivo might be evoked by net effects of the activation of these receptor subtypes.

  Kobe University, Apr. 1998, The Kobe journal of the medical sciences, 44(2) (2), 51 - 63, English


• 0458 内皮型一酸化窒素合成酵素過剰発現トランスジェニックマウスの作製と解析

  大橋 佳隆, 川嶋 成乃亮, 山下 智也, 尾崎 正憲, 石田 達郎, 平田 健一, 佐古田 剛, 井上 信孝, 横山 光宏, 栗原 裕基

  社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62, 219 - 219, Japanese


• 0461 内皮型NO合成酵素過剰発現マウスにおける血管反応性

  山下 智也, 大橋 佳隆, 川嶋 成乃亮, 尾崎 正憲, 石田 達郎, 井上 信孝, 平田 健一, 横山 光宏

  社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62, 220 - 220, Japanese


• 0462 内皮型NO合成酵素過剰発現マウスにおけるNOに対する血管弛緩反応低下の機序

  山下 智也, 大橋 佳隆, 川嶋 成乃亮, 尾崎 正憲, 石田 達郎, 井上 信孝, 平田 健一, 横山 光宏

  社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62, 220 - 220, Japanese


• 0507 動脈硬化冠動脈における5-HT1B受容体を介する過剰収縮反応とその機序の解析

  石田 達郎, 川嶋 成乃亮, 平田 健一, 佐古田 剛, 鷲見 宜彦, 秋田 穂束, 横山 光宏, 塩見 雅志

  社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62, 232 - 232, Japanese


• 0453 ヒト冠動脈内皮細胞におけるセロトニンによる一酸化窒素産生機序

  石田 達郎, 川嶋 成乃亮, 力武 良行, 佐古田 剛, 井上 信孝, 鷲見 宜彦, 横山 光宏

  社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62, 218 - 218, Japanese


• P021 動脈硬化腸骨動脈のセロトニン(5-HT)に対する過剰収縮反応と塩酸サルポグレラート(SAR)の効果

  鷲見 宜彦, 石田 達郎, 佐古田 剛, 川嶋 成乃亮, 横山 光宏, 塩見 雅志

  社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62, 390 - 390, Japanese


• Generation of transgenic mice overexpressing endothelial cell nitric oxide synthase in the vascular wall

  Y Ohashi, S Kawashima, T Yamashita, K Hirata, S Mikami, T Ishida, T Sakoda, N Inoue, M Yokoyama

  Oct. 1997, CIRCULATION, 96(8) (8), 3073 - 3073, English

  Summary international conference


• 49) 摘出冠動脈のスマトリプタンに対するsupersensitvityを認めた異型狭心症の一例

  石田 達郎, 平田 健一, 三上 修司, 金澤 健司, 竹内 素志, 川嶋 成乃亮, 秋田 穂束, 横山 光宏

  社団法人日本循環器学会, 20 Aug. 1997, Japanese circulation journal, 61, 681 - 681, Japanese


• P495 MOLECULAR ANALYSIS OF SEROTONIN (5-HYDROXY-TRYPTAMINE; 5-HT) RECEPTOR SUBTYPES IN HUMAN CORONARY ARTERIES

  Ishida Tatsuro, Sakoda Tsuyoshi, Hirata Ken-ichi, Inoue Nobutaka, Kawashima Seinosuke, Yokoyama Mitsuhiro

  Japanese Circulation Society, 20 Jun. 1997, Japanese circulation journal, 61(7) (7), 621 - 621, English


• 0677 5-HT 2A RECEPTOR T102C POLYMORPHISM IS ASSOCIATED WITH ACUTE MYOCARDIAL INFARCTION

  Yamada Shinichiro, Akita Hozuka, Kanazawa Kenji, Ishida Tatsuro, Hirata Ken-ichi, Ito Keiichi, Terashima Masahiro, Matsuda Yasuaki, Yokoyama Mitsuhiro

  Japanese Circulation Society, 20 Jun. 1997, Japanese circulation journal, 61(7) (7), 572 - 572, English


• 0683 THE N-TERMINAL MYRISTOYLATION IS IMPORTANT FOR STRETCH-INDUCED ACTIVATION OF ENDOTHELIAL CELL NITRIC OXIDE SYNTHASE

  Inoue Nobutaka, Sakoda Tsuyoshi, Ishida Tatsuro, Takeshita Saori, Yamochi Wataru, Hirata Ken-ichi, Kawashima Seinosuke, Yokoyama Mitsuhiro

  Japanese Circulation Society, 20 Jun. 1997, Japanese circulation journal, 61(7) (7), 573 - 573, English


• P495 RNase protection assayによるヒト冠動脈におけるセロトニン受容体の発現検討

  石田 達郎, 佐古田 剛, 平田 健一, 井上 信孝, 川嶋 成乃亮, 横山 光宏

  社団法人日本循環器学会, 05 Mar. 1997, Japanese circulation journal, 61, 509 - 509, Japanese


• 0683 機械的伸展刺激による血管内皮NO合成酵素活性化におけるN末端ミリスチン酸結合の果たす役割

  井上 信孝, 佐古田 剛, 石田 達郎, 竹下 佐織, 矢持 亘, 大橋 佳隆, 平田 健一, 川嶋 成乃亮, 横山 光宏

  社団法人日本循環器学会, 05 Mar. 1997, Japanese circulation journal, 61, 282 - 282, Japanese


• 0677 セロトニン2Aレセプター遺伝子多型性と心筋梗塞との関連性の検討

  山田 慎一郎, 秋田 穂束, 石田 達郎, 平田 健一, 金澤 健司, 伊東 桂一, 寺島 正浩, 松田 康章, 横山 光宏

  社団法人日本循環器学会, 05 Mar. 1997, Japanese circulation journal, 61, 281 - 281, Japanese


• P222 血管の過剰収縮に関与するセロトニン(5HT)1B受容体の細胞内情報伝達機構

  佐古田 剛, 川嶋 成乃亮, 石田 達郎, 井上 信孝, 平田 健一, 横山 光宏

  社団法人日本循環器学会, 05 Mar. 1997, Japanese circulation journal, 61, 440 - 440, Japanese


• Serotonin-mediated regulation of 5-HT2A receptor mRNA via activation of protein kinase C in vascular smooth muscle cells

  ISHIDA Tatsuro, SAKODA Tsuyoshi, HIRATA Ken-ichi, YAMAGUCHI Tsutomu, OHASHI Yoshitaka, KAWASHIMA Seinosuke, YOKOYAMA Mitsuhiro

  Japanese Circulation Society, 20 Jun. 1996, Japanese circulation journal, 60(7) (7), 502 - 502, English


• 136) アンジオテンシン変換酵素遺伝子並びにアンジオテンシノーゲン遺伝子の多様性と生検心筋所見(日本循環器学会 第79回近畿地方会)

  櫻本 博也, 川合 宏哉, 石田 達郎, 川嶋 成乃亮, 横山 光宏, 横田 慶之

  社団法人日本循環器学会, 20 Feb. 1996, Japanese circulation journal, 59, 1048 - 1048, Japanese


• 1154 血管細胞におけるエンドセリン変換酵素(ECE-1)の発現と動脈硬化による変動

  松浦 啓, 川嶋 成乃亮, 山口 務, 金澤 健司, 三上 修司, 大橋 佳隆, 石田 達郎, 矢持 亘, 横山 光宏

  社団法人日本循環器学会, 20 Feb. 1996, Japanese circulation journal, 60, 337 - 337, Japanese


• P194 血管平滑筋細胞の5-HT2A受容体mRNAのセトロニン(5-HT)による発現増加機構

  石田 達郎, 佐古田 剛, 平田 健一, 山口 務, 大橋 佳隆, 川嶋成乃 亮, 横山 光宏

  社団法人日本循環器学会, 20 Feb. 1996, Japanese circulation journal, 60, 397 - 397, Japanese


• P227 レニンアンジオテンシン系関連遺伝子多様性と特発性拡張型心筋症における心筋細胞肥大

  櫻本 博也, 秋田 穂束, 竹内 素志, 末松 正邦, 川合 宏哉, 佐古田 剛, 安住 吉弘, 石田 達郎, 横山 光宏, 横田 慶之

  社団法人日本循環器学会, 20 Feb. 1996, Japanese circulation journal, 60, 405 - 405, Japanese


• P308 低分子量G蛋白質rhoAp21の心肥大に及ぼす影響

  佐古田 剛, 川嶋 成乃亮, 上山 知己, 平岡 栄治, 石田 達郎, 平田 健一, 横山 光宏

  社団法人日本循環器学会, 20 Feb. 1996, Japanese circulation journal, 60, 426 - 426, Japanese


• Relationship Between Morphology of Coronary Artery and Serum Cholesterol Value in Patients with Ischemic Heart Disease Assessed by Intravascular Ultrasound.

  KANAZAWA Kenji, SUEMATSU Masakuni, TAKEUCHI Motoshi, KURODA Ryohei, OHASHI Yoshitaka, KURODA Yuichi, MIWA Yoichi, ISHIDA Tatsuro, YOKOYAMA Mitsuhiro

  Japanese Circulation Society, 20 Jun. 1995, Japanese circulation journal, 59(7) (7), 402 - 403, English


• Coronary Artery Wall Characteristics of Spastic Sites in Patients With Vasospastic Angina Assessed by Intravascular Ultrasound-Comparison Between Acetylcholine-and Serotonin-induced Coronary Spasm

  KANAZAWA Kenji, SUEMATSU Masakuni, TAKEUCHI Motoshi, KURODA Ryohei, OHASHI Yoshitaka, KURODA Yuichi, ISHIDA Tatsuro, YOKOYAMA Mitsuhiro

  Japanese Circulation Society, 20 Jun. 1995, Japanese circulation journal, 59(7) (7), 519 - 519, English


• MOLECULAR ANALYSIS OF 5-HYDROXY-TRIPTAMINE RECEPTORS IN HUMAN CORONARY ARTERIES

  ISHIDA Tatsuro, SAKODA Tsuyoshi, HIRATA Ken-ichi, UEYAMA Tomomi, MIKAMI Shuji, KANAZAWA Kenji, YAMOCHI Wataru, SUEMATSU Masakuni, KAWASHIMA Seinosuke, YOKOYAMA Mitsuhiro

  Japanese Circulation Society, 20 Jun. 1995, Japanese circulation journal, 59(7) (7), 473 - 473, English


• 0432 血管内超音波画像法による虚血性心疾患患者の非有意狭窄部位冠動脈壁性状と血清コレステロール値の比較検討

  金澤 健司, 末松 正邦, 竹内 素志, 黒田 良平, 大橋 佳隆, 黒田 祐一, 三輪 陽一, 石田 達郎, 横山 光宏

  社団法人日本循環器学会, 01 Mar. 1995, Japanese circulation journal, 59, 151 - 151, Japanese


• 1344 ヒト冠動脈に存在するセロトニンレセプターの遺伝子レベルにおける検討

  石田 達郎, 平田 健一, 佐古田 剛, 三上 修司, 金澤 健司, 矢持 亘, 末松 正邦, 川嶋 成乃亮, 横山 光宏

  社団法人日本循環器学会, 01 Mar. 1995, Japanese circulation journal, 59, 381 - 381, Japanese


• 0710 拡張型心筋症におけるアンギオテンシン変換酵素遺伝子の多様化とβ遮断薬療法

  櫻本 博也, 横田 慶之, 清水 雅俊, 川合 宏哉, 安住 吉弘, 井上 聡子, 石田 達郎, 佐古田 剛, 川嶋 成乃亮, 横山 光宏

  社団法人日本循環器学会, 01 Mar. 1995, Japanese circulation journal, 59, 221 - 221, Japanese


• P605 血管内超音波画像法による冠攣縮性狭心症患者のアセチルコリン、セロトニンに対する攣縮部位壁性状の検討

  金澤 健司, 末松 正邦, 竹内 素志, 黒田 良平, 大橋 佳隆, 黒田 祐一, 石田 達郎, 川嶋 成乃亮, 横山 光宏

  社団法人日本循環器学会, 01 Mar. 1995, Japanese circulation journal, 59, 553 - 553, Japanese


• Oxidized LDL and Unsaturated Fatty Acids Inhibit Receptor-Mediated Ca^<2+> Mobilization in Cultured Endothelial Cells

  Miwa Yoichi, Hirata Ken-ichi, Ishida Tatsuro, Kuroda Ryohei, Ohashi Yoshitaka, Kuroda Yuichi, Suematsu Masakuni, Kawashima Seinosuke, Yokoyama Mitsuhiro

  Japanese Circulation Society, 20 Jun. 1994, Japanese circulation journal, 58(7) (7), 453 - 453, English


• Oxidative lipoprotein and lysophosphatidylcholine upregulate cNOS mRNA expression in bovine aortic endothelial cells

  Miki Nobuhiko, Hirata Ken-ichi, Sakoda Tsuyoshi, Ishida Tatsuro, Ohashi Yositaka, Yamaguchi Tsutomu, Suematsu Masakuni, Mitsuhiro Yokoyama

  Japanese Circulation Society, 20 Jun. 1994, Japanese circulation journal, 58(7) (7), 469 - 469, English


• Angiographic Analysis of Spastic Sites Where Serotonin and Acetylcholine Provoked Coronary Vasospasms

  Kanazawa Kenji, Suematsu Masakuni, Takeuchi Motoshi, Kuroda Ryohei, Ohashi Yoshitaka, Kuroda Yuichi, Miwa Yoichi, Ishida Tatsuro, Yokoyama Mitsuhiro

  Japanese Circulation Society, 20 Jun. 1994, Japanese circulation journal, 58(7) (7), 478 - 478, English


• サイトカインによる内皮細胞由来NOS発現調節 : 第58回日本循環器学会学術集会

  三木 信彦, 平田 健一, 佐古田 剛, 石田 達郎, 大橋 佳隆, 山口 務, 末松 正邦, 横山 光宏

  社団法人日本循環器学会, 01 Mar. 1994, Japanese circulation journal, 58, 419 - 419, Japanese


• 酸化LDLおよび不飽和脂肪酸による内皮依存性血管弛緩反応抑制機序 : 第58回日本循環器学会学術集会

  三輪 陽一, 平田 健一, 石田 達郎, 黒田 良平, 大橋 佳隆, 黒田 祐一, 末松 正邦, 川嶋 成乃亮, 横山 光宏

  社団法人日本循環器学会, 01 Mar. 1994, Japanese circulation journal, 58, 28 - 28, Japanese

• 熱血循環器学 / 心血管病イベントと脂質リスク管理

  杜隆嗣, Ishida Tatsuro

  Others, 洋學社, 2019, Japanese

  Textbook


• 心血管事故を予防するための糖尿病治療戦略 / 糖尿病やメタボリックシンドローム（メタボ）に脂質異常症が高頻度に認められます。その動脈硬化における役割を教えてください

  Ishida Tatsuro, 平田健一

  Others, 文光堂, 2016, Japanese

  Scholarly book


• 疾患モデルの作製と利用−脂質代謝異常と関連疾患 / 血管内皮リパーゼ

  安田知行, Ishida Tatsuro

  Others, エル・アイ・シー, 2015, Japanese

  Scholarly book


• わかりやすい内科学第４版 / 動脈硬化

  Ishida Tatsuro, 石川雄一

  Others, 文光堂, 2014, Japanese

  Textbook


• Lipoproteins - Role in Health and Diseases / Genetically Modified Animal Models for Lipoprotein Research

  Shiomi Masashi, Koike Tomonari, Ishida Tatsuro

  Others, University Campus STeP Ri, 2012, English

  Scholarly book


• 循環器研修医ノート 改訂第2版 / 急性冠症候群における薬物療法

  Toh Ryuji, Ishida Tatsuro

  Joint work, 診断と治療社, Mar. 2010, Japanese

  Scholarly book


• 循環器ストレス学 / 脂質異常症、メタボリックシンドロームとストレス応答

  Ishida Tatsuro

  Joint work, 南山堂, Mar. 2010, Japanese

  Textbook


• Annual Review糖尿病・代謝・内分泌2010 / 血管内皮リパーゼの臨床的意義

  Ishida Tatsuro

  Joint work, 中外医学社, Jan. 2010, Japanese

  Scholarly book


• DATA UPDATE循環系 / JELIS

  Ishida Tatsuro

  Joint work, 先端医学社, 2009, Japanese

  Scholarly book


• Principles of molecular cardiology / Molecular biology applications in cardiovascular medicine

  YangE, WassermanSM, Ishida Tatsuro, TabibiazarR, QuertermousT

  Others, The Humana Press, 2005, English

  Scholarly book

• Novel Deep Venous Thrombosis Model Enabled Visualization of Thrombus Formation and Organization Process in vivo.

  Mitsumasa Okano, Tetsuya Hara, Makoto Nishimori, Koichi Watanabe, Toshihiko Oshita, Yasuhiro Irino, Satomi-Kobayashi Seimi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata

  第83回 日本循環器学会学術集会, Mar. 2019, English, 日本循環器学会, 横浜, Background: The pathogenesis of DVT (deep venous thrombosis) is still unclear, largely due to a lack of an appropriate animal model. Although stasis is a major cause of DVT formation, IVC (inferior vena cava) stasis model is not suitable for in vivo imaging because of its deep location. Method: We established a novel murine DVT model, suitable for real-time in vivo imaging. Thr, Domestic conference

  Oral presentation


• Comparison of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, and Cholesterol Efflux Capacity in Association with Coronary Plaque Properties

  Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Koichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Satomi-Kobayashi Seimi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake, Tatsuro Ishida, Kenichi Hirata

  第83回 日本循環器学会学術集会, Mar. 2019, English, 日本循環器学会, 横浜, Background: Cholesterol efflux capacity (CEC) measurement is not instantly applicable in clinical settings, because the procedures require cultured cells and are time consuming. Recently, we established a simple, high-throughout, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as “cholesterol uptake capacity (, Domestic conference

  Poster presentation


• 生活習慣病モデル動物におけるリポタンパクリパーゼ／肝性リパーゼ活性の検討

  木村 紀恵, 菊森 明生, 川瀬 大輔, 岡野 光真, 深町 久美子, ISHIDA TATSURO, 中嶋 克行, SHIOMI MASASHI

  第140回関西実験動物研究会, Dec. 2018, Japanese, 関西実験動物研究会, 京都, LPL/HTGL活性はマウスでヘパリン投与5分後に、ラット及びウサギで15-30分後に最大となった。マウスではヘパリン投与前の血漿で高いHTGL活性が認められたが、ラットやウサギでは極めて低値であった。LPL/HTGL活性測定値のCV値は4％以下であった。マウスやラットでは、LPL/HTGL活性値は給餌によって上昇したが、ウサギでは上昇しなかった。正常動物との比較では、WHHLMIウサギはLPL/HTGL活性ともに摂食時、絶食時ともに高値であったが、Zucker fattyラットは給餌下のHTGL活性に差が認められなかった。KK-Ayマウスでは、絶食下ではICRと差が認められず、給餌下でLPL/HTGL活性ともに低値であった。ヘパリン投与後のLPL/HTGL活性の上昇にともないリポタンパク中性脂肪は一過性に顕著に低下した。 ヒト用に開発されたLPL/, Domestic conference

  Oral presentation


• Comparison of Clinical Utility Between Cholesterol Uptake Capacity, a Novel Indicator of HDL Functionality, and Cholesterol Efflux Capacity

  Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Koichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Satomi-Kobayashi Seimi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake, Tatsuro Ishida, Ken-ichi Hirata

  第35回 国際心臓研究学会日本部会, Dec. 2018, English, 国際心臓研究学会日本部会, 東京, Background: Cholesterol efflux capacity (CEC) measurement is not instantly applicable in clinical settings, because the methods require cultured cells, and the procedures are time consuming. Recently, we established a simple, high-throughout, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as “cholesterol upta, Domestic conference

  Poster presentation


• 新規マウス血栓モデルによるDVT生体イメージング

  岡野 光真, HARA TETSUYA, 西森 誠, 渡部 晃一, 尾下 寿彦, IRINO YASUHIRO, Satomi-Kobayashi Seimi, SHINOHARA MASAKAZU, TOH RYUJI, ISHIDA TATSURO, HIRATA KENICHI

  第1回 日本腫瘍循環器学会, Nov. 2018, Japanese, 日本腫瘍循環器学会, 東京, 背景: 担癌患者では血栓形成傾向による静脈血栓症の合併が多いが、深部静脈血栓症(DVT)の詳細な機序は未だに不明である。血流鬱滞はDVT形成要因の一つであるが、既存の下大静脈結紮モデルは時間空間解像度の観点から生体イメージングには適さない。リアルタイムイメージングに用いられる既存の血栓モデルは内皮傷害による血小板血栓であり、DVT形成機序の理解には新たな静脈血栓モデルが求められる。方法: 大腿静脈結紮による血流鬱滞と蛍光顕微鏡観察による光照射で、リアルタイムに形成されるマウスDVTモデルを確立した。結果: 本モデルの血栓は、血管長軸方向に伸展する形態かつフィブリンを伴う赤色血栓であり、ヒトDVTに病態生理学的に類似する。また好発部位である静脈弁に血栓が形成されやすく、血栓溶解や血栓塞栓子遊離の観察も可能である。血栓形成時には赤血球凝集が先行し、既存の, Domestic conference

  Oral presentation


• 高比重リポタンパクによる酸化ストレスに対する心保護作用は PI3K/mTOR シグナリング経路を介する

  渡部晃一, TOH RYUJI, 西森誠, 岡野光真, 尾下寿彦, 林友鴻, 長尾学, IRINO YASUHIRO, HARA TETSUYA, SHINOHARA MASAKAZU, Satomi-Kobayashi Seimi, ISHIDA TATSURO, HIRATA KENICHI

  第1回 日本腫瘍循環器学会, Nov. 2018, Japanese, 日本腫瘍循環器学会, 東京, 背景：高比重リポタンパク (High-density lipoprotein；HDL) は心血管系に対して多面的な効果を有することが知られている。HDLがドキソルビシンによる活性酸素種の生成を介した心筋障害から細胞保護効果を示すことが報告されているが、心筋細胞に対して及ぼす直接的な影響は十分に明らかにされていない。目的：HDLが酸化ストレス下において心筋細胞へ及ぼす効果を検証する。方法と結果：H9C2細胞に対して、HDLによる前処理を加えた後にH2O2 による酸化ストレス刺激を加えると、HDLの容量依存性に細胞保護効果を示すことを明らかにした。HDLによる処理は、H9C2細胞のAktのリン酸化を有意に増加させ、一方PI3K阻害剤であるLY294002、mTOR阻害剤であるラパマイシンを投与することにより、Aktのリン酸化ならびにHDLの有する抗アポト, Domestic conference

  Oral presentation


• Reduction of 5-Lipoxygenase Derived Docosahexaenoic Acid Metabolites Under Social Mental Stress: Their Function for Maintenance of Heme Oxygenase-1 Expression in Macrophage

  Makoto Nishimori, Masakazu Shinohara, Kouichi Watanabe, Mitsumasa Okano, Toshihiko Oshita, Kenta Mori, Tetsuya Hara, Yasuhiro Irino, Satomi-Kobayashi Seimi, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata

  American Heart Association's 2018 Scientific Sessions, Nov. 2018, English, シカゴ, Epidemiological studies reveal an association between social mental stresses and incidence of cardiovascular disease. Although hyperactivation of sympathetic nerve system is reported to induce systemic inflammation, little is known regarding precise mechanisms how social mental stress induces systemic inflammation and cardiovascular events. We have developed liquid chromatograp, International conference

  Poster presentation


• Establishment of Novel Deep Venous Thrombosis Model Suitable for in vivo Imaging

  Mitsumasa Okano, Tetsuya Hara, Makoto Nishimori, Koichi Watanabe, Toshihiko Oshita, Yasuhiro Irino, Satomi-Kobayashi Seimi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata

  American Heart Association Scientific Sessions 2018., Nov. 2018, English, American Heart Association, シカゴ, Backgrounds: The pathogenesis of DVT (deep venous thrombosis) is still unclear, largely due to a lack of an appropriate animal model. Although stasis is a major cause of DVT formation, IVC (inferior vena cava) stasis model is not suitable for in vivo imaging because of its deep location. Real-time imaging in other thrombosis models including FeCl3 and laser injury showed the ro, International conference

  Oral presentation


• Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, Versus Cholesterol Efflux Capacity in Association with Coronary Plaque Lipid Burden

  Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Koichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Satomi-Kobayashi Seimi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake, Tatsuro Ishida, Kenichi Hirata

  American Heart Association Scientific Sessions 2018., Nov. 2018, English, American Heart Association, シカゴ, Background: Cholesterol efflux capacity (CEC) measurement is not instantly applicable in clinical settings, because the methods require cultured cells, and the procedures are time consuming. Recently, we established a simple, high-throughout, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as “cholesterol upta, International conference

  Poster presentation


• Elevation of Serum Trans-fatty Acids Level as a Possible Risk for Target Lesion Revascularization After Coronary Intervention

  Toshihiko Oshita, Ryuji Toh, Kenta Mori, Yasuhiro Irino, Masakazu Shinohara, Hiromasa Otake, Tatsuro Ishida, Kenichi Hirata

  第66回 日本心臓病学会学術集会, Aug. 2018, English, 日本心臓病学会, 大阪, L) (92.7% vs. 70.0%, p=0.004). In addition, the cox proportional hazard models revealed that elevated serum EA level to be an independent element in predicting of TLR after adjusting for traditional coronary risks (HR, 1.06; 95% CI, 1.00-1.12; p=0.04).Conclusions: The present findings indicated that the elevation of serum TFAs could be a cardiovascular risk in Japan., Domestic conference

  Oral presentation


• Understanding of HDL Cholesterol Efflux Capacity: Towards Clinical Application

  Ryuji Toh, Tatsuro Ishida, Kenichi Hirata

  第50回 日本動脈硬化学会総会・学術集会, Jul. 2018, English, 日本動脈硬化学会, 大阪, While there is a controversy regarding a causal relationship between high-density lipoprotein cholesterol (HDL-C) and cardiovascular disease (CVD), recent studies have demonstrated that the cholesterol efflux capacity (CEC) of HDL is associated with CVD incidence. However, there are several limitations to current CEC assays. First, CEC measurement is not instantly applicable in, Domestic conference

  Public symposium


• Searching for modulating factor of cholesterol uptake capacity, a novel indicator for HDL functionality

  Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Shigeyasu Tsuda, Koichi Watanabe, Satomi-Kobayashi Seimi, Tetsuya Hara, Masakazu Shinohara, Yasuhiro Irino, Katsuhiro Murakami, Amane Harada, Tatsuro Ishida, Kenichi Hirata

  第50回 日本動脈硬化学会総会・学術集会, Jul. 2018, Japanese, 日本動脈硬化学会, 大阪, Background: Recently, we established a simple, high-throughput, cell-free assay system to evaluate the capacity of high-density lipoprotein (HDL) to accept additional cholesterol, named cholesterol uptake capacity (CUC). CUC could be an indicator of HDL function for coronary risk stratification. In this study, we sought to identify modulating factors of CUC. Methods: We used nu, Domestic conference

  Poster presentation


• Real-Time in Vivo Imaging of Thrombosis Initiated by Red Blood Cell Aggregation in Novel Murine Stasis Model of DVT

  Mitsumasa Okano, Tetsuya Hara, Makoto Nishimori, Koichi Watanabe, Toshihiko Oshita, Shigeyasu Tsuda, Kenta Mori, Yasuhiro Irino, Satomi-Kobayashi Seimi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata

  第50回 日本動脈硬化学会総会・学術集会, Jul. 2018, Japanese, 日本動脈硬化学会, 大阪, Background: Stasis is a major cause of DVT (deep venous thrombosis) formation. IVC (inferior vena cava) stasis model is not suitable for in vivo imaging because of its deep location. Real-time imaging in other thrombosis models including FeCl3 and laser injury showed the roles of platelets and leukocytes in the initiation of DVT, but they are mainly caused by endothelial injury, Domestic conference

  Poster presentation


• Novel murine deep venous thrombosis (DVT) model enables real-time in vivo imaging of clinically relevant DVT.

  Mitsumasa Okano, Tetsuya Hara, Yasuhiro Irino, Satomi-Kobayashi Seimi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata

  International Academy of Cardiology Annual Scientific Sessions 2018 23rd World Congress on Heart Disease, Jul. 2018, English, International Academy of Cardiology, ボストン, Background: The pathogenesis of deep venous thrombosis (DVT) is still unclear, largely due to a lack of an adequate animal model. Although stasis is a major cause of DVT formation, inferior vena cava stasis model is not suitable for in vivo imaging because of its deep location. Other thrombosis models allowing in vivo imaging such as FeCl3 and laser injury induce platelet throm, International conference

  Oral presentation


• HDLから産生される機能性脂質：HDL-細胞間相互作用に与える影響

  SHINOHARA MASAKAZU, ISHIDA TATSURO

  第50回 日本動脈硬化学会総会・学術集会, Jul. 2018, Japanese, 日本動脈硬化学会, 大阪, HDLを構成するApo A-Iは流動性が高く、様々なタンパク質がHDL上に共存することが知られ ている。我々は、HDL上に機能性脂質を産生する酵素群が存在しているという仮説を立て検 証した。 健常人と動脈硬化病変を繰り返す患者の保存血漿からHDLを精製し、それぞれのHDLから産 生される機能性脂質を包括的に解析したところ、動脈硬化症例HDLから炎症惹起性のロイコ トリエンB4(LTB4)が産生されることを見出した。HDLに含有されるタンパク質をウェスタンブロット法にて評価すると、動脈硬化症例のHDLではLTB4産生に関わる酵素群が検出され た。一方、健常人のHDLではLTB4産生に関わる酵素群は全く検出されない。したがって、こ れらの酵素群は血液中を循環している間にHDL上に“移ってきた”可能性が高い。動脈硬化症例 HDL, Domestic conference

  Public symposium


• A Novel Mechanism of Regulation of the 5-Lipoxygenase/Leukotrien B4 pathway by High-density Lipoprotein in Macrophages

  Shigeyasu Tsuda, Masakazu Shinohara, Toshihiko Oshita, Manabu Nagao, Tetsuya Hara, Yasuhiro Irino, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata

  第50回 日本動脈硬化学会総会・学術集会, Jul. 2018, Japanese, 日本動脈硬化学会, 大阪, High-density lipoprotein (HDL) interacts with various cells, particularly macrophages, in functional cell-HDL interactions. Here, we found that HDL “protein quality” and “lipid quality” play critical roles in HDL functions. HDL from healthy volunteers (HDLHealthy) and recurrent coronary atherosclerotic disease patients (HDLCAD) was prepared. To analyze functional HDL-macrophage, Domestic conference

  Poster presentation


• WHHLMIウサギにおける冠動脈病変の発生・進行に関わる血漿マーカーの同定

  SHIOMI MASASHI, 竹田 浩章, IRINO YASUHIRO, ユウ イン, 小池 智也, 和泉 自泰, SHINOHARA MASAKAZU, 馬場 健史, ISHIDA TATSURO

  第50回日本動脈硬化学会総会・学術集会, Jun. 2018, Japanese, 日本動脈硬化学会, 大阪, 冠動脈病変の程度には大きな個体差が認められたが、リポタンパク脂質と大動脈病変では両群間に統計的な差は認められなかった。リピドーム解析において、冠動脈病変が重度のウサギでは4月齢と8月齢でセラミド（d18:1-18:0, d18:1-18:2, d18:1-20:2, d18:1-22:0, d18:1-22:1, d18:1-22:2, d18:1-22:4, 全セラミド）が高値を示し、20月齢でトリアシルグリセロール44：0と44:1が低値を示した。リピドーム解析で検出されたこれらのパラメータは冠動脈病変重症化の血中マーカーとして有用であると考えられる。, Domestic conference

  Poster presentation


• Identification of novel lipid markers for coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia

  Masashi Shiomi, Hiroaki Takeda, Yasuhiro Irino, Satoshi Yamada, Nobue Kuniyoshi, Yu Ying, Tomonari Koike, Yoshihiro Izumi, Masakazu Shinohara, Takeshi Bamba, Tatsuro Ishida

  ISA 2018, Jun. 2018, English, International Atherosclerosis Society, Toronto, [Purpose] We have previously suggested that risk factors for coronary atherosclerosis may be different from those for aortic atherosclerosis. To identify specific markers for coronary atherosclerosis, we have performed comprehensive analysis of plasma of WHHLMI rabbits, which spontaneously develop coronary atherosclerosis. [Methods] WHHLMI rabbits (n=20) were fed a standard cho, International conference

  Poster presentation


• WHHLMIウサギにおける冠動脈病変の発生・進行に関わる血漿マーカー

  SHIOMI MASASHI, 竹田 浩章, IRINO YASUHIRO, ユウ イン, 小池 智也, 和泉 自泰, SHINOHARA MASAKAZU, 馬場 健史, ISHIDA TATSURO

  第65回日本実験動物学会総会・学術集会, May 2018, Japanese, 日本実験動物学会, 富山, [Purpose] The purpose of this study is to identify biomarkers for coronary lesions. [Methods] Ultracentrifugation of plasma lipoproteins, metabolome analyses and lipidome analyses of plasma were performed. Coronary lesions were evaluated by cross-sectional narrowing. The severity of aortic lesions was evaluated by percentage of lesion area on aortic surface. [Results] Despite, Domestic conference

  Poster presentation


• Development of markers for progression of coronary plaques using WHHLMI rabbits, an animal model of familial hypercholesterolemia

  Masashi Shiomi, Hiroaki Takeda, Yasuhiro Irino, Satoshi Yamada, Nobue Kuniyoshi, Yu Ying, Tomonari Koike, Yoshihiro Izumi, Masakazu Shinohara, Takeshi Bamba, Tatsuro Ishida

  ESC Congrss 2018, May 2018, English, European Atherosclerosis Society, Lisbon, [Purpose] To identify novel markers for cardiovascular disease, comprehensive plasma analyses were performed using WHHLMI rabbits which spontaneously develop coronary atherosclerosis. [Methods] WHHLMI rabbits were fed a standard chow. Plasma were collected from 20 WHHLMI rabbits under fasting at intervals of 4 months from 4 months of age. Lipoprotein was fractionated with an ul, International conference

  Poster presentation


• 新規マウス血栓モデルによる赤血球凝集主体のDVT生体イメージング

  岡野 光真, HARA TETSUYA, 西森 誠, 渡部 晃一, 尾下 寿彦, 津田 成康, IRINO YASUHIRO, Satomi-Kobayashi Seimi, SHINOHARA MASAKAZU, TOH RYUJI, ISHIDA TATSURO, HIRATA KENICHI

  第55回 日本臨床分子医学会学術集会, Apr. 2018, Japanese, 日本臨床分子医学会, 京都, 背景: 血流鬱滞はDVT形成要因の一つであるが、既存の下大静脈結紮モデルは時間・空間解像度の観点から生体イメージングには適さない。リアルタイムイメージングに用いられる既存の血栓モデルは内皮傷害による血小板血栓であり、DVT形成機序の理解には新たな静脈血栓モデルが求められる。方法: 大腿静脈結紮による血流鬱滞と蛍光顕微鏡観察による励起光照射で、リアルタイムに形成されるマウスDVTモデルを確立した。結果: 本モデルの血栓は、血管長軸方向に伸展する形態かつフィブリンネットワークを伴う赤色血栓であり、ヒトDVTに病理生態学的に類似する。また好発部位である静脈弁や血管合流部など血流鬱滞部が起始部になりやすい。血栓形成時には赤血球凝集が先行し、内皮傷害血栓モデルに見られる血小板や白血球は目立たず、フィブリンとともに遅れて集積して器質化する。器質化の程度によって、, Domestic conference

  Poster presentation


• HDL機能の新規評価法“Cholesteroluptakecapacity”とOCT解析によ る冠動脈プラーク病変性状の比較検討

  尾下寿彦, TOH RYUJI, IRINO YASUHIRO, 黒田浩史, 永野雄一郎, 長澤圭典, OTAKE HIROMASA, SHINKE TOSHIRO, ISHIDA TATSURO, HIRATA KENICHI

  第55回 日本臨床分子医学会学術集会, Apr. 2018, Japanese, 日本臨床分子医学会, 京都, 【背景】 高比重リポ蛋白（HDL）の、コレステロールをマクロファージより引き抜く能力cholesterol efflux capacityがHDL中のコレステロール（HDL-C）値より心血管疾患のリスク評価に優れるが、その従来の測定法は放射性同位体や培養細胞を要すなど臨床応用は非現実的であった。当施設で、HDLのコレステロール取り込み能をより簡便に評価できる新規HDL機能評価法“cholesterol uptake capacity (CUC)”を構築し、臨床応用を目指している。この引き抜き能と動脈硬化病変のプラーク性状の関係性に関しこれまでに十分評価はされていない。【方法】 冠動脈病変に対し冠動脈造影検査および光干渉断層映像法（OCT）を施行した135例でCUCを測定しOCT画像解析によるプラーク性状との比較検討を行った。OCT画像上、脂質プラーク, Domestic conference

  Poster presentation


• Relationships between Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, and Morphologic Features of Coronary Plaque

  Toshihiko Oshita, Toh Ryuji, Yuichiro Nagano, Koji Kuroda, Yoshinori Nagasawa, Amane Harada, Katsuhiro Murakami, Irino Yasuhiro, Hara Tetsuya, Shinohara Masakazu, Otake Hiromasa, Shinke Toshiro, Ishida Tatsuro, Hirata Ken-ichi

  The 82th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2018, English, Japanese Circulation Society, 大阪, Background: Recently, we established a simple, high-throughput, cell-free assay system to evaluate the capacity of high-density lipoprotein (HDL) to accept additional cholesterol, named cholesterol uptake capacity (CUC). In this study, we sought to clarif, Domestic conference

  Poster presentation


• Phospholipid Composition of Reconstitute High Density Lipoproteins Affects their Anti-inflammatory Effects

  Mitsumasa Okano, Irino Yasuhiro, Shinohara Masakazu, Nobuaki Tanaka, Toshihiko Oshita, Shigeyasu Tsuda, Koichi Watanabe, Kenta Mori, Hara Tetsuya, Ishida Tatsuro, Hirata Ken-ichi, Toh Ryuji

  The 82th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2018, English, Japanese Circulation Society, 大阪, Objective:We previously reported that oral administration of eicosapentaenoic acid (EPA) generates EPA-rich high-density lipoprotein (HDL) particles with a variety of anti-inflammatory properties, highlighting the relationship between phospholipid species, Domestic conference

  Poster presentation


• Novel mechanism of regulation of the 5-lipoxygenase/leukotriene B4 pathway by high-density lipoprotein in macrophages

  Shigeyasu Tsuda, Shinohara Masakazu, Toshihiko Oshita, Manabu Nagao, Hara Tetsuya, Irino Yasuhiro, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  The 82th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2018, English, Japanese Circulation Society, 大阪, High-density lipoprotein (HDL) interacts with various cells, particularly macrophages, in functional cell-HDL interactions. Here, we found that HDL protein quality and lipid quality play critical roles in HDL functions. HDL fractions from healthy voluntee, Domestic conference

  Poster presentation


• In Vivo Imaging Revealed Platelet- and Leukocyte- independent Initiation of Deep Venous Thrombosis (DVT) in Novel Murine DVT Model

  Mitsumasa Okano, Hara Tetsuya, Toshihiko Oshita, Shigeyasu Tsuda, Koichi Watanabe, Kobayashi Seimi, Irino Yasuhiro, Shinohara Masakazu, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  The 82th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2018, English, Japanese Circulation Society, 大阪, Background: Although past reports showed the role of platelets and leukocytes in the initiation of DVT, the underlying mechanism is not fully understood.Method: We established a novel DVT model, suitable for in vivo imaging; DVT can be formed and visualiz, Domestic conference

  Poster presentation


• Impaired HDL cholesterol uptake capacity which measure HDL functionality might promote neoatherosclerosis formation after stent implantation

  Yuichiro Nagano, Otake Hiromasa, Amane Harad, Katsuhiro Murakami, Toshihiko Oshita, Irino Yasuhiro, Takayoshi Toba, Koji Kuroda, Natsuko Tahara, Yuto Shinkura, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Akira Nagasawa, Hiroyuki Onishi, Youichirou Sugizaki, RyoTakeshige, Hiroyuki Kawamori, Shinke Toshiro, Ishida Tatsuro, Toh Ryuji, Hirata Ken-ichi

  American College Of Cardiology 67th Annual Scientific Session(ACC2018), Mar. 2018, English, American College Of Cardiology, オーランド, 米国, International conference

  Poster presentation


• Identification of Determinants of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality

  Toshihiko Oshita, Toh Ryuji, Mitsumasa Okano, Shigeyasu Tsuda, Ko-ichi Watanabe, Kobayashi Seimi, Hara Tetsuya, Shinohara Masakazu, Irino Yasuhiro, Katsuhiro Murakami, Amane Harada, Ishida Tatsuro, Hirata Ken-ichi

  The 82th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2018, English, Japanese Circulation Society, 大阪, Background: Recently, we established a simple, high-throughput, cell-free assay system to evaluate the capacity of high-density lipoprotein (HDL) to accept additional cholesterol, named cholesterol uptake capacity (CUC), and demonstrated its feasibility f, Domestic conference

  Poster presentation


• 高塩分食品・調味料等の使用習慣に基づいた食塩摂取量簡易評価方法の検討

  脇田 久美子, 三ヶ尻 礼子, 田渕 聡子, 山西 美沙, 山下 弘子, 山本 育子, Matsuda Yoshiko, Takahashi Michiko, Ogawa Wataru, Kobayashi Seimi, Toh Ryuji, Ishida Tatsuro, 大瀬良 知子, 栗原 伸公

  第3回日本心臓リハビリ―ション学会近畿支部地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference

  Poster presentation


• 高塩分食品・調味料等の使用習慣に基づいた食塩摂取量簡易評価方法の検討

  脇田 久美子, 三ヶ尻 礼子, 田渕 聡子, 山西 美沙, 山本 育子, Matsuda Yoshiko, Takahashi Michiko, Ogawa Wataru, Kobayashi Seimi, Toh Ryuji, Ishida Tatsuro, 赤毛 弘子, 大瀬良 知子, 栗原 伸公

  第3回 日本心臓リハビリテーション学会 近畿地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference

  Poster presentation


• 高血圧患者における高塩分食品・調味料の使用習慣に基づいた塩分摂取量簡易評価方法の検討

  脇田 久美子, 三ヶ尻 礼子, 田渕 聡子, 山西 美沙, 赤毛 弘子, 玉田 萌子, 西田 ひかる, 中谷 早希, 金谷 沙紀, 森 智子, 向山 万為子, 中村 美仁, 山本 育子, Matsuda Yoshiko, Takahashi Michiko, Ogawa Wataru, Kobayashi Seimi, Ishida Tatsuro, 大瀬良 知子, 栗原 伸公

  第21回病態栄養学会年次学術集会, Jan. 2018, Japanese, 日本病態栄養学会, 京都, Domestic conference

  Oral presentation


• Progression of Calcific Aortic Valve Sclerosis in WHHL Rabbits, an Animal Model of Aortic Valve Stenosis

  Hara Tetsuya, Norie Tsukada, Ishida Tatsuro, Hirata Ken-ichi, Shiomi Masashi

  American Heart Association Scientific sessions 2017, Nov. 2017, English, American Heart Association, Anaheim, USA, Background: Recent development of transcatheter aortic valve implantation (TAVI) improved the therapeutic strategy of aortic valve stenosis (AS). However, the pathogenesis of calcification in aortic valve remains largely unknown, mostly due to the lack of, International conference

  Poster presentation


• Novel Mechanism of High-Density Lipoprotein to Regulate 5-Lipoxygenase/Leukotriene B4 Pathway in Macrophages.

  Shigeyasu Tsuda, Shinohara Masakazu, Mitsumasa Okano, Toshihiko Oshita, Manabu Nagao, Hara Tetsuya, Irino Yasuhiro, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  The Scientific Sessions of the American Heart Association, 2017, Nov. 2017, English, the American Heart Association, Anahaim, 米国, International conference

  Poster presentation


• Association of Coronary Lipidic Plaque Burden with Impairment of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality: OCT-based Observation Study

  Toshihiko Oshita, Toh Ryuji, Yuichiro Nagano, Koji Kuroda, Yoshinori Nagasawa, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Irino Yasuhiro, Otake Hiromasa, Shinke Toshiro, Ishida Tatsuro, Hirata Ken-ichi

  American Heart Association Scientific sessions 2017, Nov. 2017, English, American Heart Association, Anaheim, USA, Background: Recent studies have shown that the capacity of high density lipoprotein (HDL) to stimulate cholesterol efflux from lipid-laden macrophages is a better predictor of cardiovascular disease than overall HDL cholesterol level. However, the convent, International conference

  Oral presentation


• Role of exogenous lipids in progression of coronary lesion during LDL-C lowering therapy

  Ishida Tatsuro, Hirata Ken-ichi, Sakaguchi Kazuhiko

  The 15th Annual Meeting of Japanese Society of Hospital General Medicine, Sep. 2017, Japanese, Japanese Society of Hospital General Medicine, 浦安, なし, Domestic conference

  Oral presentation


• Novel mechanism of high-density lipoprotein to regulate 5-lipoxygenase/leukotrien B4 pathway in macrophages

  Tsuda S, Shinohara Masakazu, Oshita T, Nagao M, Hara Tetsuya, Irino Yasuhiro, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  The 49th Annual Scientific Meeting of the Japan Atherosclerosis Society, Jul. 2017, Japanese, Japan Atherosclerosis Society, 広島, High-density lipoprotein (HDL) interacts with various cells, particularly macrophages, in functional cell-HDL interactions. Here, we found that HDL “protein quality” and “lipid quality” play critical roles in HDL functions. HDL from healthy volunteers (HD, Domestic conference

  Poster presentation


• Elevated serum trans-fatty acid as a risk for cardiovascular event recurrence in Japan

  Oshita T, Toh Ryuji, Irino Yasuhiro, Shinohara Masakazu, Shinke Toshiro, Ishida Tatsuro, Hirata Ken-ichi

  The 49th Annual Scientific Meeting of the Japan Atherosclerosis Society, Jul. 2017, Japanese, Japan Atherosclerosis Society, 広島, Background: Trans-fatty acids (TFAs) intake has been known to increase cardiovascular risk in Western countries. Recently, we demonstrated that serum TFA concentration was elevated in young patients with coronary artery disease in Japan. In this study, we, Domestic conference

  Poster presentation


• Consumption of Beverages Sweetened with Fructose or High Fructose Corn Syrup (HFCS), but not Glucose for 2 weeks Impairs Cholesterol Efflux Capacity compared with Aspartame in Men and Women

  Kenta Mori, Candice A Price, Vivien Lee, Marinelle V Nunez, Guoxia X Chen, Desiree M Sigala, Ishida Tatsuro, Peter J Havel, Kimber L Stanhope

  The 49th Annual Scientific Meeting of the Japan Atherosclerosis Society, Jul. 2017, Japanese, Japan Atherosclerosis Society, 広島, Diet intervention studies have demonstrated that consumption of sugar-sweetened beverages (SSBs) at 25% of energy requirements (Ereq) increases circulating triglycerides and lipoprotein risk factors for cardiovascular disease (CVD), while circulating HDL-, Domestic conference

  Poster presentation


• Cardioprotective effects of high-density lipoprotein against oxidative stress by regulating PI3K/mTOR signaling pathway

  Nagao M, Toh Ryuji, Irino Yasuhiro, Nakajima H, Okano M, Oshita T, Tsuda S, Hara Tetsuya, Shinohara Masakazu, Ishida Tatsuro, Hirata Ken-ichi

  The 49th Annual Scientific Meeting of the Japan Atherosclerosis Society, Jul. 2017, Japanese, Japan Atherosclerosis Society, 広島, The inverse relationships between circulating high density lipoprotein cholesterol (HDL-C) levels and incidence of coronary heart disease have been demonstrated in multiple human population studies. On the other hand, it has been also shown that low plas, Domestic conference

  Poster presentation


• A pediatric ETV6-ABL1-positive acute lymphoblastic leukemia case with ETV6-ABL1-indepent acquired resistance to tyrosine kinase inhibitor

  Uemura S, Hasegawa D, Shono Akemi, Thwin KKM, Nino N, Takafuji S, Mori Takeshi, Tamura A, Yamamoto N, Saito A, Kishimoto K, Ishida Tatsuro, Kosaka Y, Iijima Kazumoto, Nishimura Noriyuki

  Pediatric Cancer Research, May 2017, English, American association for cancer research, Atlanta, USA, International conference

  Poster presentation


• Inverse Association Between HDL Cholesterol Uptake Capacity And Coronary Atherosclerotic Burden: OCT-based Observation Study

  Toshihiko Oshita, Toh Ryuji, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Kenta Mori, Irino Yasuhiro, Otake Hiromasa, Shinke Toshiro, Ishida Tatsuro, Hirata Ken-ichi

  The 82st Annual Scientific Meetign of the Japanese Circulation Society, Mar. 2017, English, Japanese Circulation Society, 金沢, Background: High-Density lipoprotein (HDL) function is a better predictor of cardiovascular disease than HDL cholesterol level. Recently, we established a simple, high-throughout, cell-free assay system to evaluate "cholesterol uptake capacity (CUC)" as a, Domestic conference

  Oral presentation


• Elevated Serum Trans-fatty Acid is a Predictive Cardiovascular Risk in Japan

  Toshihiko Oshita, Toh Ryuji, Kenta Mori, Irino Yasuhiro, Shinohara Masakazu, Shinke Toshiro, Ishida Tatsuro, Hirata Ken-ichi

  The 83st Annual Scientific Meetign of the Japanese Circulation Society, Mar. 2017, Japanese, Japanese Circulation Society, 金沢, Background: Trans-fatty acids (TFAs) intake has been known to increase cardiovascular risk in Western countries. Recently, we demonstrated that serum TFA concentration was elevated in young patients with coronary artery disease in Japan. In this study, we, Domestic conference

  Oral presentation


• De novo leukotriene B4 production from high density lipoproteins (HDL) in recurrent cardiovascular disease patients attenuates anti-inflammatory properties of HDL

  Shigeyasu Tsuda, Shinohara Masakazu, Mitsumasa Okano, Toshihiko Oshita, Manabu Nagao, Hara Tetsuya, Irino Yasuhiro, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  The 81st Annual Scientific Meetign of the Japanese Circulation Society, Mar. 2017, English, Japanese Circulation Society, 金沢, We recently reported that serum myeloperoxidase/paraoxonase-1 (MPO/PON1) ratio could be a useful marker for high density lipoprotein (HDL) function and elevated ratio correlated to recurrent cardiovascular diseases. We hypothesized that HDL from high MPO/, Domestic conference

  Oral presentation


• Clinical and Practical Assessment of Dysfunctional HDL in Cardiovascular Risk Stratification

  Ishida Tatsuro, Toh Ryuji, Otake Hiromasa, Shinke Toshiro, Amane Harada, Hirata Ken-ichi

  The 85st Annual Scientific Meetign of the Japanese Circulation Society, Mar. 2017, English, Japanese Circulation Society, 金沢, While there is a controversy regarding the clinical significance of high-density lipoprotein cholesterol (HDL-C), recent studies have highlighted the quality of HDL particle as a novel target for cardiovascular risk stratification. However, it is difficul, Domestic conference

  Keynote oral presentation


• 2-aminobutyric acid as a newly identified modulator of glutathione homeostasis in failing myocardium

  Manabu Nagao, Toh Ryuji, Irino Yasuhiro, Tanaka Hidekazu, Shinke Toshiro, Ishida Tatsuro, Hirata Ken-ichi

  The 84st Annual Scientific Meetign of the Japanese Circulation Society, Mar. 2017, English, Japanese Circulation Society, 金沢, We conducted a comprehensive quantification of serum metabolites using gas chromatography-mass spectrometry in patients with atrial septal defect to find clues for understanding myocardial metabolic regulation, and demonstrated that circulating 2-aminobut, Domestic conference

  Oral presentation


• Compensatory Accumulation of Myocardial β-Hydroxybutyrate Accompanied by SCOT Downregulation in Response to Oxidative Stress

  Manabu Nagao, Toh Ryuji, Irino Yasuhiro, Takeshige Mori, Hara Tetsuya, Tomoyuki Honjo, Kobayashi Seimi, Shinke Toshiro, Tanaka Hidekazu, Ishida Tatsuro, Hirata Ken-ichi

  ISHR 2016, Dec. 2016, Japanese, International Society for Heart Research, 東京, Recent studies have shown that the ketone body -hydroxybutyrate (βOHB) acts not only as a carrier of energy but also as a signaling molecule that has a role in diverse cellular functions. Circulating βOHB levels have been previously reported to be increa, Domestic conference

  Oral presentation


• De Novo Leukotriene B4 Production from High-Density Lipoprotein (HDL) in Recurrent Cardiovascular Disease Patients Deteriorates Anti-inflammatory Properties of HDL

  Shigeyasu Tsuda, Shinohara Masakazu, Toshihiko Oshita, Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Hara Tetsuya, Irino Yasuhiro, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  American Heart Association Scientific sessions 2016, Nov. 2016, English, American Heart Association, New Orleans, USA, Background- We recently reported that serum myeloperoxidase/paraoxonase 1 (MPO/PON1) ratio could be used as a useful marker for high density lipoprotein (HDL) function and elevated MPO/PON1 ratio correlated to recurrent cardiovascular diseases. We hypothe, International conference

  Oral presentation


• Compensatory Accumulation of βHydroxybutyrate Accompanied by SCOT Downregulation in Failing Hearts

  Manabu Nagao, Toh Ryuji, Irino Yasuhiro, Takeshige Mori, Hara Tetsuya, Tomoyuki Honjo, Kobayashi Seimi, Shinke Toshiro, Tanaka Hidekazu, Ishida Tatsuro, Hirata Ken-ichi

  American Heart Association Scientific sessions 2016, Nov. 2016, English, American Heart Association, New Orleans, USA, Background and ObjectiveCirculating levels of ketone bodies have been previously reported to be increased in patients with congestive heart failure (HF). Recent studies have shown that the ketone body β-hydroxybutyrate (βOHB) acts not only as a carrier of, International conference

  Poster presentation


• Cholesterol Uptake Capacity: A New Measure of HDL Functionality for Coronary Risk Stratification

  Amane Harada, Toh Ryuji, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Takuya Kubo, Irino Yasuhiro, Kenta Mori, Nobuaki Tanaka, Kunihiro Nishimura, Ishida Tatsuro, Hirata Ken-ichi

  American Heart Association Scientific sessions 2016, Nov. 2016, English, American Heart Association, New Orleans, USA, Introduction: Recent studies have shown that the capacity of high-density lipoprotein (HDL) to stimulate cholesterol efflux from lipid-laden macrophages is a better predictor of cardiovascular disease status than overall HDL cholesterol (HDL-C) concentrat, International conference

  Poster presentation


• Reemergence of a translocation t(11;19)(q23;p13.1) in the absence of leukemia

  Saito A, Hasegawa D, Uemura S, Nino N, Takafuji S, Yokoi T, Tahara T, Tamura A, Kozaki A, Kishimoto K, Ishida Tatsuro, Kawasaki K, Yamamoto Nobuyuki, Mori Takeshi, Nishimura Noriyuki, Kosaka Y

  第79回日本血液学会学術集会, Oct. 2016, Japanese, 日本血液学会, 横浜, Domestic conference

  Poster presentation


• Aggressive double-hit leukemia/lymphoma with t(14;18)(q32;q21) and t(8;21)(q24;q11.2)

  Uemura S, Hasegawa D, Nino N, Takafuji S, Yokoi T, Tahara T, Tamura A, Saito A, Kozaki A, Kishimoto K, Ishida Tatsuro, Kawasaki K, Yamamoto Nobuyuki, Mori Takeshi, Hayakawa A, Nishimura Noriyuki, Kosaka Y

  第78回日本血液学会学術集会, Oct. 2016, Japanese, 日本血液学会, 横浜, Domestic conference

  Poster presentation


• Impact of cholesterol uptake/efflux capacity of HDL on coronary artery disease

  Toh Ryuji, Ishida Tatsuro, 原田周, 吉田智一, Hirata Ken-ichi

  64th Annual Scientific Session of the Japanese College of Cardiology, Sep. 2016, Japanese, Japanese College of Cardiology, 東京, 高比重リポ蛋白（HDL）粒子は多彩な動脈硬化抑制作用を持ち、これまではHDLの量的指標として血漿HDLコレステロール（HDL-C）濃度が用いられてきた。しかし、最近の介入試験ではHDL-C上昇薬の心血管イベント抑制効果は証明されず、HDLの機能、とくにコレステロール引抜き能と動脈硬化との関係が重要視されている。従来のコレステロール引抜きの測定には、放射性標識コレステロールを培養マクロファージに取り込ませ、HDLの代用としてポリエチレングリコールによるアポB除去血清に引き抜かれたコレステロールを測定するため、簡便性や再現性で多くの問題があった。我々は、 放射性同位元素や培養細胞を用いずに、血清中のHDL粒子に蛍光標識コレステロールを直接取込ませ、プレートに固相化したアポA-I抗体でHDLを捕捉した後のHDLの蛍光強度を「HDL特異的コレステロール取込み, Domestic conference

  [Invited]

  Nominated symposium


• Cholesterol uptake capacity, a new concept of HDL functionality, for risk stratification in coronary artery disease

  Toh Ryuji, Harada A, Murakami K, Kiriyama M, Yoshikawa K, Miwa Kuniko, Irino Yasuhiro, Mori K, Tanaka N, Nishimura K, Ishida Tatsuro, Hirata Ken-ichi

  68th AACC Annual Scientific Meeting & Clinical Lab Expo, Aug. 2016, English, American Sciety of Clinical Chemistry, Philadelphia, USA, International conference

  Poster presentation


• Anti-inflammatory function of HDL depends on its phospholipid composision

  田中伸明, Irino Yasuhiro, Shinohara Masakazu, 津田成康, 長尾学, 森健茂, 森健太, Hara Tetsuya, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  48th Annual Scientific Session of the Japanese Society of Atherosclerosis, Jul. 2016, Japanese, Japanese Society of Atherosclerosis, 東京, Domestic conference

  Poster presentation


• Evaluation of anti-inflammatory- and cholesterol efflux activities of HDL and its role in coronary artery disease

  Ishida Tatsuro

  48th Annual Scientific Session of the Japanese Society of Atherosclerosis, Jul. 2016, Japanese, Japanese Society of Atherosclerosis, 東京, HDL粒子は、コレステロール逆転送、抗炎症、抗酸化などの多彩な動脈硬化抑制作用を持ち、これまでは血漿HDLコレステロール(HDL-C)値がHDLの量的指標と考えられてきた。しかし、最近の介入試験ではHDL-C上昇薬の心血管イベント抑制効果は証明されず、HDLの機能評価が重要視されるようになった。HDL粒子はリン脂質や蛋白量が豊富で、それぞれがHDLの多彩な機能を担っている。 HDLリン脂質の脂肪酸組成は冠動脈疾患の重症度と相関する。培養血管内皮細胞をHDLと共培養し、VCAM-1の発現量を指標にHDLの抗炎症能を評価すると、飽和脂肪酸やトランス脂肪酸に富むHDLは抗炎症作用が減弱したのに対して、n-３系不飽和脂肪酸に富むHDLは抗炎症作用が増強していた。 一方、抗酸化酵素であるパラオキソナーゼ1（PON1）はHDL中に存在し、その血中濃度はHDLの抗, Domestic conference

  [Invited]

  Nominated symposium


• HDLの抗炎症能・コレステロール引抜き能の評価方法の確立と動脈硬化における意義.

  Ishida Tatsuro

  第48回日本動脈硬化学会総会・学術集会, Jul. 2016, Japanese, 日本動脈硬化学会, 東京, Domestic conference

  Oral presentation


• Treatment of dyslipidemia including exogenous lipids

  Ishida Tatsuro

  The 29th Japanese Coronary Association, Nov. 2015, Japanese, Japanese Coronary Association, 札幌, アテローム性動脈硬化疾患を予防する上で血清脂質の管理は最も重要であり、ガイドラインではスタチンによるLDLの管理が推奨されている。スタチン投与後の残余リスクとして、低HDL血症や高トリグリセリド血症の重要性も認識されてはいるが、治療薬の選択が困難で適切に管理されていないことが多い。肝臓由来のLDLを内因性脂質と捕らえると、食事由来の外因系脂質は、コレステロール、脂肪酸、リン脂質、中性脂肪など多彩であり、動脈硬化惹起性成分も多く含まれている。冠動脈疾患患者やスタチン投与患者では、外因系脂質マーカー（アポB48、トランス脂肪酸、コレステロール吸収マーカー等）が上昇し、これがステント治療後の新規病変の出現と関連している。とくに糖尿病患者では、外因系脂質の影響が強くスタチン投与後の動脈硬化リスクとなっており、症例によって積極的介入が必要性が示唆される。最近は, Domestic conference

  [Invited]

  Invited oral presentation


• Risk evaluation of trans fat in Japan

  Ishida Tatsuro

  日本臨床栄養学会2015年度認定臨床栄養医研修会, Nov. 2015, Japanese, Japanese Society of Clinical Nutrition, 大阪, Domestic conference

  [Invited]

  Invited oral presentation


• Targeted Disruption of JCAD/KIAA1462, a Coronary Artery Disease-associated Gene Product, Inhibits Angiogenic Processes in Vitro and in Vivo.

  Tetsuya Hara, Tomoko Monguchi, Akashi Masaya, Noriko Iwamoto, Kenta Mori, Toh Ryuji, Irino Yasuhiro, Shinohara Masakazu, Mikio Furuse, Ishida Tatsuro, Hirata Ken-ichi

  American Heart Association Scientic Session 2015., Nov. 2015, English, American Heart Association, Orlando, USA, Background: Recent genome-wide association studies newly identified the human KIAA1462 gene as a new locus for coronary artery disease. However, the function of the gene product, named JCAD (junctional protein associated with coronary artery disease), is, International conference

  Poster presentation


• Serum Trans Fatty Acid Level impacts Coronary artery disease in Japanese Young Generation

  Kenta Mori, Ishida Tatsuro, Tomoyuki Yasuda, Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Hideto Nakajima, Tetsuya Hara, Tomoyuki Honjo, Irino Yasuhiro, Shinohara Masakazu, Toh Ryuji, Hirata Ken-ichi

  The 49th Annual Scientific Meeting of the Japanese Atherosclerosis Society, Jul. 2015, Japanese, Japanese Atherosclerosis Society, 仙台, Background: Although the adverse effect of dietary trans fatty acids (TFA) on coronary artery disease (CAD) has been well recognized in western countries, its impact remains unclear in Japan. We investigated the impact of serum TFA concentration and TFA i, Domestic conference

  Poster presentation


• Serum Myeloperoxidase/Paraoxonase 1 Ratio Predicts Recurrent Coronary Artery Disease

  Shigeyasu Tsuda, Toh Ryuji, Kenta Mori, Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Tomoko Monguchi, Hideto Nakajima, Tomoyuki Honjo, Shinohara Masakazu, Kunihiro Nishimura, Ishida Tatsuro, Hirata Ken-ichi

  The 49th Annual Scientific Meeting of the Japanese Atherosclerosis Society, Jul. 2015, Japanese, Japanese Atherosclerosis Society, 仙台, Myeloperoxidase (MPO) is major leukocyte enzyme that oxidizes lipoproteins. High density lipoprotein (HDL) contains paraoxonase 1 (PON1), which hydrolyzes oxidized phospholipids. We recently reported that serum MPO/PON1 ratio could be a useful marker for, Domestic conference

  Poster presentation


• Immunoreactivity against Lipopolysaccharide from Porphyromonas Gingivalis Can Predict Secondary Prevention of Coronary Atherosclerosis

  Nobuaki Tanaka, Tomoyuki Honjo, Toh Ryuji, Masato Mitsuhashi, Manabu Nagao, Takeshige Mori, Tomoko Monguchi, Kenta Mori, Ishida Tatsuro, Hirata Ken-ichi

  The 49th Annual Scientific Meeting of the Japanese Atherosclerosis Society, Jul. 2015, Japanese, Japanese Atherosclerosis Society, 仙台, Observational studies support an association between periodontal disease (PD) and coronary artery disease (CAD). We aimed to develop a novel blood test to predict secondary prevention of CAD by using lipopolysaccharide from Porphyromonas gingivalis (Pg) w, Domestic conference

  Poster presentation


• 冠動脈疾患二次予防における予測因子としての血清ミエロペルオキシダーゼ/パラオキソナーゼ1比の有用性についての検討

  Shigeyasu Tsuda, Toh Ryuji, Kenta Mori, Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Tomoko Monguchi, Hideto Nakajima, Tomoyuki Honjo, Shinohara Masakazu, Kunihiro Nishimura, Ishida Tatsuro, Hirata Ken-ichi

  The 15th Annual Scientific Meeting of the NO Society of Japan, Jun. 2015, Japanese, NO Society of Japan, 大阪, 【背景】ミエロペルオキシダーゼ（MPO）はHDLの主要リポ蛋白であるApoA-1を酸化修飾し、HDLのコレステロール引き抜き能を減弱させる。他方、パラオキソナーゼ１（PON1）はApoA-Iと結合しHDL自体の酸化を抑制し、またeNOSの活性化し、NOを介してHDLによる血管内皮機能の制御に関与する。近年、HDL上でMPOはPON1を酸化し、その活性を低下させるとともに、PON1がMPOによるリポ蛋白の酸化修飾を抑制し、両者のバランスがHDL機能に重要な役割を担っていることが示唆されている。我々はこれまでに、血中におけるMPO/PON1比がHDLのコレステロール引き抜き能や抗炎症作用を反映し、さらに経皮的冠動脈形成術（PCI）後の患者において再PCIを要した群では要さなかった群よりも有意にMPO/PON1比が高かったことを報告した。しかしながら、MP, Domestic conference

  Oral presentation


• 2-Aminobutyric acid reflects myocardial redox state in doxorubicin-induced cardiomyopathy

  Manabu Nagao, Toh Ryuji, Irino Yasuhiro, Takeshige Mori, Tomoyuki Honjo, Kobayashi Seimi, Shinohara Masakazu, Shinke Toshiro, Ishida Tatsuro, Hirata Ken-ichi

  11th International Conference of the Metabolomics Society (Metabolomics 2015), Jun. 2015, English, Metaboomics Society, San Francisco, USA, Introduction:Clinical usage of doxorubicin (DOX) as a chemotherapeutic drug is limited by cumulative dose-related cardiotoxicity caused by oxidative stress. Empiric dose limitation is insufficient to prevent DOX-induced cardiotoxicity due to a great varia, International conference

  Poster presentation


• Serum myeloperoxidase/paraoxonase 1 ration predicts recurrent coronary artery disease

  Tsuda S, Toh Ryuji, Mori K, Nagao M, Tanaka N, Mori Takeshi, Monguchi T, Nakajima H, Honjo T, Shinohara Masakazu, Nishimura K, Ishida Tatsuro, Hirata Ken-ichi

  ATVB/PVD2015, May 2015, English, American Heart Association, San Francisco, USA, OBJECTIVE: Myeloperoxidase (MPO) promotes oxidation of lipoproteins, while paraoxonase 1 (PON1) has antioxidant properties against atherosclerosis. We reported that serum MPO/PON1 ratio is a potential indicator of dysfunctional high-density lipoprotein a, International conference

  Poster presentation


• Analyses of Serum and Thrombus Fatty Acid Composition at the onset of Acute Coronary Syndrome in Japan

  Tomoyuki Yasuda, Makoto Kadotani, Hiroki Shimizu, Yasuhiro Irio, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi, Yoshio Ohnishi

  17th INTERNATIONAL SYMPOSIUM ON ATHEROSCLEROSIS, May 2015, English, INTERNATIONAL SOCIETY OF ATHEROSCLEROSIS, Amsterdam, Netherland, International conference

  Poster presentation


• Increased Serum Cholesterol Esterification Rates is associated with Future Coronary Heart Disease and Sudden Death in a General Population

  Shin-ichiro Tanaka, Tomoyuki Yasuda, Ishida Tatsuro, Yoshio Fujioka, Takeshi Tsujino, Tetsuo Miki, Hirata Ken-ichi

  The 79th Annual Scientific Meeting of the Japanese Circulation Society, Apr. 2015, English, Japanese Circulation Society, 大阪, Background: Cholesterol esterification takes place in plasma high-density lipoprotein-cholesterol (HDL-C) fraction, which is catalyzed by plasma Lecithin:Cholesterol Acyltransferase (LCAT). Therefore, this reaction is thought to be important in reverse ch, Domestic conference

  Oral presentation


• Immunoreactivity against Lipopolysaccharide from Porphyromonas Gingivalis Can Predict Secondary Prevention of Coronary Artery Disease

  Nobuaki Tanaka, Tomoyuki Honjo, Toh Ryuji, Masato Mitsuhashi, Manabu Nagao, Takeshige Mori, Tomoko Monguchi, Kenta Mori, Ishida Tatsuro, Hirata Ken-ichi

  The 79th Annual Scientific Meeting of the Japanese Circulation Society, Apr. 2015, English, Japanese Circulation Society, 大阪, Background: Observational studies support an association between periodontal disease (PD) and coronary artery disease (CAD). We aimed to develop a novel blood test to predict secondary prevention of CAD by using lipopolysaccharide from Porphyromonas gingi, Domestic conference

  Oral presentation


• Immune Response Against Oxdized Low-Density Lipoprotein as a New Risk Stratification in Coronary Artery Disease

  Tomoyuki Honjo, Toh Ryuji, Nobuaki Tanaka, Masato Mitsuhashi, Kenta Mori, Takeshige Mori, Manabu Nagao, Ishida Tatsuro, Hirata Ken-ichi

  The 79th Annual Scientific Meeting of the Japanese Circulation Society, Apr. 2015, English, Japanese Circulation Society, 大阪, Background: We aimed to develop a novel blood test for risk stratification in coronary artery disease (CAD) by the immune response against oxidized low-density lipoprotein (oxLDL). Methods: A total of 43 patients with prior history of CAD were enrolled. H, Domestic conference

  Poster presentation


• Feasibility of 2-Aminobutyric acid as a biomarker for early detection of doxorubicin-induced cardiotoxicity

  Manabu Nagao, Toh Ryuji, Irino Yasuhiro, Takeshige Mori, Tomoyuki Honjo, Kobayashi Seimi, Shinohara Masakazu, Shinke Toshiro, Ishida Tatsuro, Hirata Ken-ichi

  The 79th Annual Scientific Meeting of the Japanese Circulation Society, Apr. 2015, English, Japanese Circulation Society, 大阪, Background:Empiric dose limitation is insufficient to prevent doxorubicin (DOX)-induced cardiotoxicity due to a great variability in individual DOX tolerance. Recently, we revealed that 2-aminobutyric acid (2-AB) was produced as a byproduct of glutathione, Domestic conference

  Oral presentation


• Ex Vivo Simulation of the Immune Response Against Oxdized Low-Density Lipoprotein as a New Risk Stratification in Coronary Artery Disease

  Tomoyuki Honjo, Toh Ryuji, Nobuaki Tanaka, Masato Mitsuhashi, Kenta Mori, Takeshige Mori, Manabu Nagao, Ishida Tatsuro, Hirata Ken-ichi

  American College of Cardiology Scientific Session 2015, Mar. 2015, English, American college of Cardiology, サンディエゴ, アメリカ, Background: Although previous reports showed that circulating oxidized low-density lipoprotein (oxLDL) levels correlated with the severity of coronary artery disease (CAD), the clinical utility of oxLDL as a biomarker is not established yet. We have recently developed a new system that can quantify the accurate expression of leukocyte mRNA by real time polymerase chain reactio, International conference

  Poster presentation


• Oral administration of eicosapentaenoic acid ameliorates anti-inflammatory functions of high-density lipoprotein in dyslipidemic patients

  Nobuaki Tanaka, Ishida Tatsuro, Manabu Nagao, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kenta Mori, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Toh Ryuji, Hirata Ken-ichi

  American Heart Association Scientific Sessions 2014, Nov. 2014, English, American Heart Association, シカゴ, アメリカ, Objective:Previous studies have reported that inflammation converts high-density lipoprotein (HDL) to dysfunctional form lacking its anti-inflammatory properties. However, little is known about pharmacological therapy to improve HDL function. It has been recently postulated that fatty acid component in HDL-phospholipids modulates HDL functions. We investigated the effect of, International conference

  Poster presentation


• Circulating levels of 2-Aminobutyric acid reflect myocardial redox state in patients with atrial septal defects

  Irino Yasuhiro, Toh Ryuji, Takeshige Mori, Manabu Nagao, Tomoyuki Honjo, Kobayashi Seimi, Shinke Toshiro, Ishida Tatsuro, Okiko Miyata, Hirata Ken-ichi

  American Heart Association Scientific Sessions 2014, Nov. 2014, English, American Heart Association, シカゴ, アメリカ, Heart failure (HF) is a major cause of morbidity and mortality worldwide. However, conventional biomarkers are insufficient to detect early stage of HF and identification of more sensitive markers is an urgent task. We conducted the comprehensive quantification of water-soluble metabolites in blood of atrial septal defect (ASD) patients using a gas chromatograph-mass spectromet, International conference

  Poster presentation


• 2-Aminobutyric acid, a potential indicator of oxidative stress in failing hearts

  Toh Ryuji, Irino Yasuhiro, Takeshige Mori, Manabu Nagao, Tomoyuki Honjo, Kobayashi Seimi, Ishida Tatsuro, Okiko Miyata, Hirata Ken-ichi

  The 18th Annual Scientific Meeting of the Japanese Heart Failure Society, Oct. 2014, Japanese, The Japanese Heart Failure Society, 大阪, Early diagnosis of heart failure (HF) remains difficult and identification of more sensitive biomarkers than conventional ones is an urgent task. We conducted the comprehensive quantification of water-soluble metabolites in blood of atrial septal defect (ASD) patients using a gas chromatograph-mass spectrometry. We found the mean level of 2-Aminobutyric acid (2-AB) in ASD patie, Domestic conference

  Oral presentation


• Exploration of biomarkers for the detection of heart failure

  Irino Yasuhiro, Toh Ryuji, 森 健茂, 長尾 学, 本庄 友行, Kobayashi Seimi, Shinke Toshiro, Ishida Tatsuro, 宮田 興子, Hirata Ken-ichi

  The 39th Annual Meeting of the Japanese Soxiety for Biomedical Mass Spectrometry, Oct. 2014, Japanese, The Japanese Soxiety for Biomedical Mass Spectrometry, 千葉, (Background) Heart failure (HF) is a major cause of morbidity and mortality worldwide. However, conventional biomarkers are insufficient to detect early stage of HF and identification of more sensitive markers is an urgent task.(Methods) We conducted the comprehensive quantification of water-soluble metabolites in blood of atrial septal defect (ASD) patients using a gas chromat, Domestic conference

  Poster presentation


• High susceptibility of atherosclerotic coronary arteries to the onset of vasospasm and angina pectoris due to coronary spasm in WHHLMI rabbits

  Yin Yu, Koike Tomonari, Ishida Tatsuro, Satoshi Yamada, Shiori Tamura, Nobue Kuniyoshi, Hirata Ken-ichi, Shiomi Masashi

  The 2nd Sino-Japan Rabbit Model Meeting, Aug. 2014, English, Japanese Association of Rabbit Bioscience, Changchun, China, Coronary atherosclerosis of WHHLMI rabbits showed high susceptibility to the onset of vasospasm and angina pectoris-like symptoms due to coronary spasm., International conference

  Oral presentation


• High-density lipoprotein excerts a variety of protective effects for cardiomyocyte.

  中島英人, Ishida Tatsuro, Hirata Ken-ichi

  The 46th Annual Sientific Meeting of the Japan Atherosclerosis Society, Jul. 2014, English, Japan Atherosclerosis Society, 東京, 疫学•臨床研究から、低脂血症は非虚血性心不全の増悪因子であることや、血清高比重リポ蛋白コレステロール(HDL-C)値が心不全死亡リスクと逆相関傾向を示すことが報告され, 血清脂質が心不全修飾因子として作用することが示唆されている。HDLはコレステロール逆転送以外に抗炎症作用、抗酸化作用、抗アポトーシス作用、内皮機能改善作用など多面的作用を有することが知られている。そこで我々は、HDLが培養心筋細胞に及ぼす影響について検討した。ラット新生仔から分離した心筋細胞を用いて、HDLによる種々の心筋細胞保護作用を検討した。培養心筋細胞を、蛍光性脂溶性分子であるDiIで標識したHDLを添加して培養したところ、DiI標識HDLの心筋細胞内への顕著な取り込みを認めた。すなわち、HDL由来の脂質成分が心筋細胞に取り込まれ、利用される可能性が示された。つぎに、血清を除去, Domestic conference

  Poster presentation


• Serum trans fatty acid concentration can be controlled by treatments with ezetimibe or EPA

  Takeshige Mori, Ishida Tatsuro, Nobuaki Tanaka, Tomoko Monguchi, Kenta Mori, Maki Sasaki, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Tomoyuki Yasuda, Irino Yasuhiro, Toh Ryuji, Hirata Ken-ichi

  The 46th Annual Sientific Meeting of the Japan Atherosclerosis Society, Jul. 2014, English, Japan Atherosclerosis Society, 東京, Objective: Trans fatty acids (TFA) have various pro-atherogenic effects, and cause adverse health effects including cardiovascular diseases. However, little is known regarding pharmacological treatments to attenuate TFA effects. We evaluated the effects of ezetimibe and eicosapentaenoic acid (EPA) on serum TFA concentration.Methods: A prospective intervention study was perform, Domestic conference

  Poster presentation


• Inflammation-Activated Angptl3-Endothelial Lipase System Regulates Serum HDL-C Levels in Acute Coronary Syndrome

  Kenta Mori, Ishida Tatsuro, Kazuya miyashita, Noriaki Kinoshita, Hideto Nakajima, Tomoyuki Yasuda, Toh Ryuji, Masahito Kawata, Susumu Sakamoto, Katsuyuki Nakajima, Hirata Ken-ichi

  The 46th Annual Sientific Meeting of the Japan Atherosclerosis Society, Jul. 2014, English, Japan Atherosclerosis Society, 東京, Backgrounds: It has been recognized that serum high-density lipoprotein cholesterol (HDL-C) concentrations are reduced in acute myocardial infarction. Endothelial lipase (EL) is a regulator of HDL-C and EL expression is regulated in acute inflammatory response. We investigate the association of circulating EL mass and HDL-C in acute coronary syndrome (ACS).Methods: Serum sampl, Domestic conference

  Poster presentation


• Impact of endothelial lipase on the low HDL-cholesterol level under inflammatory conditions

  Ishida Tatsuro, Hirata Ken-ichi

  The 46th Annual Sientific Meeting of the Japan Atherosclerosis Society, Jul. 2014, English, Japan Atherosclerosis Society, 東京, Endothelial lipase (EL) has been reported to regulate the metabolism of high-density lipoprotein cholesterol (HDL-C). Existing data suggest that inhibition of EL in humans would be expected to increase HDL-C levels. However, it has not been definitively established whether the effect of EL activity on HDL-C levels translates into effects on reverse cholesterol transport or at, Domestic conference

  [Invited]

  Nominated symposium


• Eicosapentaenoic acid improves anti-inflammatory functions of high-density lipoprotein in dyslipidemic patients

  Nobuaki Tanaka, Ishida Tatsuro, Manabu Nagao, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kenta Mori, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honj, Toh Ryuji, Hirata Ken-ichi

  The 46th Annual Sientific Meeting of the Japan Atherosclerosis Society, Jul. 2014, English, Japan Atherosclerosis Society, 東京, Objective: Dysfunctional high-density lipoprotein (HDL) lacks its anti-inflammatory properties and promotes atherosclerosis. However, little is known regarding pharmacologic therapies improving HDL function. We investigated the effect of eicosapentaenoic acid (EPA) on HDL functions.Methods: Patients with dyslipidemia were treated with 1800 mg/day EPA for 4 weeks, and HDL frac, Domestic conference

  Poster presentation


• Effect of trans fatty acid on inflammation, oxidative stress, and atherosclerosis in a murine model of atherosclerosis

  門口倫子, Ishida Tatsuro, 中島英人, 安田知行, 近藤健介, 森健太, 佐々木真希, Shinohara Masakazu, Toh Ryuji, Hirata Ken-ichi

  The 14th Annual Sientific Meeting of the NO Society of Japan, May 2014, Japanese, NO Society of Japan, Saga, Japan, 【目的】疫学的研究によりトランス脂肪酸(TFA)が心血管疾患の危険因子であることが証明されている。しかし、TFAの炎症惹起や動脈硬化促進作用の機序は完全には明らかになっていない。今回我々は、LDL受容体欠損マウス(LDL-R KOマウス)とマウスのマクロファージ由来細胞株であるRAW264.7を用いて、TFAが炎症・動脈硬化・酸化ストレスに与える影響を調べた。また、TFAとToll-like受容体4(TLR4)シグナル伝達経路の関与について検討した。【方法】1) 動物実験：６週齢の雄のLDL-R KOマウスを、トランス群（普通食+0.5％コレステロール+5%エライジン酸(v/v)）、シス群（普通食+0.5％コレステロール+5%オレイン酸(v/v)）、対照群(普通食＋0.5％コレステロール)に分けた。８週間負荷後、血中の脂質・脂肪酸プロファイル・酸化L, Domestic conference

  Poster presentation


• Trans fatty acid increases thrombogeneity of endothelial cells via TLR-dependent pathway

  近藤健介, Ishida Tatsuro, 安田知行, 長尾学, 森健茂, 田中伸明, 門口倫子, 森健太, 佐々木真希, 中島英人, Toh Ryuji, Hirata Ken-ichi

  The 14th Annual Sientific Meeting of the NO Society of Japan, May 2014, Japanese, NO Society of Japan, Saga, Japan, 目的：トランス脂肪酸（Trans Fatty Acid: TFA ）は、血管内の炎症を惹起し心筋梗塞発症のリスクを増加させることが知られているが、血管内皮機能に対する直接の作用には不明な点が多い。血管内皮細胞は、血栓形成•抑制に関与する多彩な分子を発現し、血栓形成を制御している。そこで我々は、TFAが血管内皮細胞の抗血栓性に及ぼす影響とその分子機序を検討した。方法：ヒト臍帯静脈内皮細胞(HUVEC)を、種々の濃度のTFA(エライジン酸)、または対照としてシス脂肪酸(CFA, オレイン酸)にて刺激を行い、トロンボモジュリン（TM）、Tissue Factor Pathway Inhibitor（TFPI）、plasminogen activator inhibitor-1（PAI-1）、組織因子（TF）、およびtumor necrosis factor, Domestic conference

  Poster presentation


• Effect of apoB-100-derived pepitide vaccine on blood pressure and renal function

  本庄友行, Toh Ryuji, PK Shah, Ishida Tatsuro, Hirata Ken-ichi

  The 14th Annual Sientific Meeting of the NO Society of Japan, May 2014, Japanese, NO Society of Japan, Saga, Japan, 背景：Angiotensin II （AngII）による血圧上昇および腎障害には、活性酸素種（ROS）や炎症性サイトカイン産生に代表される腎実質の炎症や腎線維化が関係していると考えられている。また、我々は最近apoB-100由来のペプチドワクチン（p210ワクチン）が、CD8＋T細胞の免疫調整を介してapoE(-/-)マウスの動脈硬化を抑制し、更にはAngIIによる大動脈瘤をも抑制することを報告した。活性化されたT細胞はAngIIによる血圧上昇に重要な役割を持っていることから、本研究ではAngIIに対するp210ワクチンの血圧および腎障害への効果について検討した。方法と結果：オスapoE(-/-)に対し7・10・12週齢時に、p210ワクチン（p210群）もしくはコントロール2群（cBSA群・PBS群）を皮下注にて投与した。10週齢時に浸透圧ポンプを, Domestic conference

  Poster presentation


• Impact of Serum Mass of Endothelial Lipase on Serum High-Density Lipoprotein-Cholesterol Concentrations in Acute Myocardial Infarction

  Kenta Mori, Ishida Tatsuro, Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Toh Ryuji, Masahito Kawata, Susumu Sakamoto, Hirata Ken-ichi

  The 78th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2014, Japanese, Japanese Circulation Society, 東京, Backgrounds; Endothelial lipase (EL) is a regulator of serum HDL-C level. EL is upregulated in inflammation and inactivated by angiopoietin-like protein 3 (ANGPTL3). However, its significance in acute myocardial infarction (AMI) remains unknown. We investigated the role of circulating EL in AMI.Methods; Serum samples were collected over time from AMI patients. EL and ANGP, Domestic conference

  Poster presentation


• Impact of oral eicosapentaenoic acid therapy on High-Density Lipoprotein function in patients with high risk of atherosclerosis

  Nobuaki Tanaka, Ishida Tatsuro, Manabu Nagao, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kenta Mori, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Toh Ryuji, Hirata Ken-ichi

  The 78th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2014, Japanese, Japanese Circulation Society, 東京, Objective: Previous studies have shown that dysfunctional high-density lipoprotein (HDL) lacks anti-inflammatory functions and promotes atherosclerosis. However, the therapy improving HDL function is not currently available. We aimed to evaluate the effect of oral administration of eicosapentaenoic acid (EPA) on HDL functions.Methods and Results: Patients with one or more cor, Domestic conference

  Poster presentation


• Effect of cholesteryl ester transfer protein inhibitor on anti-inflammatory properties of high-density lipoproteins

  Kenta Mori, Ishida Tatsuro, Tomoyuki Yasuda, Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Shiomi Masashi, Hirata Ken-ichi

  The 78th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2014, Japanese, Japanese Circulation Society, 東京, Background: Recent clinical trials using cholesteryl ester transfer protein (CETP) inhibitors failed to establish any beneficial effect on clinical outcomes, while the detailed mechanism remains unclear. We investigated the effect of torcetrapib, a CETP inhibitor, on the quality of high-density lipoproteins using dyslipidemic rabbits. Method:Myocardial Infarction-Prone Watanab, Domestic conference

  Oral presentation


• 食事による血管内皮リパーゼ誘導が血清HDLコレステロール値に及ぼす影響についての検討

  Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  第17回日本心血管内分泌代謝学会学術総会, Nov. 2013, Japanese, 日本心血管内分泌代謝学会, 大阪, Domestic conference

  Poster presentation


• 難治性高血圧症患者におけるロサルタンカリウム・ヒドロクロロチアジドの左室肥大に対する効果：Kobe-CONNECT試験心エコー図サブ解析

  大西 哲在, Toh Ryuji, Ishida Tatsuro, 江本 憲昭, 川合 宏哉, Hirata Ken-ichi, 横山 光弘

  第61回心臓病学会, Sep. 2013, Japanese, Japanese College of Cardiology, 熊本, Domestic conference

  Oral presentation


• Damages of coronray plaques and development of acute myocardial ischemia induced by coronary casospasm in WHHLMI rabbits

  Koike Tomonari, Ishida Tatsuro, 山田 悟士, 国吉 信恵, Yu Ying, Hirata Ken-ichi, 伊藤 隆, Shiomi Masashi

  The 45th Annual Scientific Meeting of the Japan Atherosclerosis Society, Jul. 2013, Japanese, the Japan Atherosclerosis Society, 東京, We provoked coronary vasospasm in WHHLMI rabbits and observed that coronary spasm caused disruption of coronary plaques and occurrence of acute myocardial ischemia., Domestic conference

  Poster presentation


• Dietary intake of trans-fatty acid accelerates thrombus formation through inhibiting anti-thrombogenic actions of vascular endothelium

  近藤健介, Ishida Tatsuro, 安田知行, 山本順一郎, 門口倫子, 森健太, 佐々木真希, 破磯川実, 原口英子, 中島英人, 篠原正和, Toh Ryuji, Hirata Ken-ichi

  The 45th Annual Scientific Meeting of the Japan Atherosclerosis Socienty, Jul. 2013, Japanese, Japan Atherosclerosis Socienty, 東京, Purpose: Although trans-fatty acid (TFA) is known to promote atherosclerosis, the role of TFA in thrombus formation remains unknown. We investigated the mechanism of TFA in thrombogenesis in vitro and in vivo.Methods and Results:C57BL6 mouse were treated with TFA (2% elaidic acid), cis-fatty acid (2% oleic acid) or normal chow diet for 4 weeks and thrombus formations induced b, Domestic conference

  Poster presentation


• Trans-fatty acid accelerates thrombus formation in vivo through inhibiting endothelial anti-thrombogenic actions

  Kensuke Kondo, Tomoyuki Yasuda, Tomoko Monguchi, Kenta Mori, Minoru Hasokawa, Yoko Haraguchi, Hideto Nakajima, Masakazu Shinohara, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  The 81st Congress of the European Atherosclerosis Society (EAS 2013), Jun. 2013, English, European Atherosclerosis Society, Lyon, France, [Purpose]Excessive intake of trans-fatty acids (TFA) has been reported to increase the risk of myocardial infarction (MI), but the detailed mechanism has not been elucidated. We aimed to investigate the effect of TFA on thrombus formation in vitro and in vivo. [Methods]C57BL6 mouse were fed with TFA (2% elaidic acid), cis-fatty acid (2% oleic acid) or normal chow diet for 4 wee, International conference

  Poster presentation


• Role of endothelial lipase in high-density lipoprotein (HDL) metabolism in humans

  Ishida Tatsuro, Hirata Ken-ichi

  The 81st Congress of the European Atherosclerosis Society (EAS 2013), Jun. 2013, English, European Atherosclerosis Society, Lyon, France, Purpose: Endothelial lipase (EL) has been implicated in the regulation of plasma HDL-cholesterol levels. However, the detailed role of EL in HDL metabolism cardiovascular disease (CVD) has been incompletely understood in humans. We aimed to better characterize the impact of plasma EL mass and activity in plasma HDL-cholesterol level in human subjects.Methods: Plasma samples we, International conference

  Poster presentation


• Increases of Serum Mass of Endothelial Lipase Impact Plasma High-Density Lipoprotein-Cholesterol Concentrations in Acute Myocardial Infarction

  Kenta Mori, Ishida Tatsuro, Kazuya Miyashita, Noriaki Kinoshita, Hideto Nakajima, Tomoyuki Yasudaa, Ryuji Tohc, Masahito Kawatad, Susumu Sakamotod, Katsuyuki Nakajima, Hirata Ken-ichi

  The 81st Congress of the European Atherosclerosis Society (EAS 2013), Jun. 2013, English, European Atherosclerosis Society, Lyon, France, Objective: Endothelial lipase (EL) is a regulator of serum high-density lipoprotein cholesterol (HDL-C) concentrations. Although EL expression is highly regulated in acute inflammation, its functional significance remains unknown. We aimed to investigate the association of circulating EL mass and HDL-C levels in acute myocardial infarction (AMI) in humans. Methods: Serum sampl, International conference

  Poster presentation


• Impact of Serum Trans Fatty Acid Level in Risks of Coronary Artery Disease in Japan

  Kenta Mori, Ishida Tatsuro, Nobuaki Tanaka, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Minoru Hasokawa, Hideto Nakajima, Yoko Haraguchi, Li Sun, Tomoyuki Yasuda, Masakazu Shinohara, Toh Ryuji, Hirata Ken-ichi

  The 81st Congress of the European Atherosclerosis Society (EAS 2013), Jun. 2013, English, European Atherosclerosis Society, Lyon, France, Aim: Trans fatty acids (TFA) have been reported to have a variety of atherogenic properties. Dietary intake of TFA in Japan is much lower than that in western countries, and it remains unknown whether serum concentration of TFA is a coronary risk in Japan. We aim to investigate the significance of TFA in coronary artery disease (CAD) in Japan.Methods: Fasting serum samples wer, International conference

  Poster presentation


• Trans fatty acids increase inflammatory cytokines in plasma and aorta and decrease fatty acid elongation in LDL receptor knockout mice

  Minoru Hasokawa, Masakazu Shinohara, Tomoyuki Yasuda, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  The 77th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, TFAs promote arteriosclerosis multiple mechanisms including upregulation of inflammatory cytokines, promotion of LDL oxidation, and inhibition of the fatty acid elongation., Domestic conference

  Poster presentation


• Serum Trans Fatty Acid concentration is a Risk Factors for Coronary Artery Disease in Japan

  Kenta Mori, Ishida Tatsuro, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Minoru Hasokawa, Hideto Nakajima, Yoko Haraguchi, Li Sun, Tomoyuki Yasuda, Masakazu Shinohara, Toh Ryuji, Hirata Ken-ichi

  The 77th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, The serum TFA concentration is a risk factor of CAD in Japan, and would cause a serious health problem particularly in the young generation. TFA has unrecognized adverse health effects in atherosclerosis., Domestic conference

  Poster presentation


• Exogenous and Intestinal Derived lipids Reflected Residual Risks for Coronary Artery Disease during LDL-Lowering Therapy

  Kenta Mori, Ishida Tatsuro, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Minoru Hasokawa, Hideto Nakajima, Yoko Haraguchi, Li Sun, Tomoyuki Yasuda, Masakazu Shinohara, Toh Ryuji, Hirata Ken-ichi

  The 77th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, Serum concentration of apoB48, cholesterol absorption markers, and TFA is a predictor of coronary lesion progression during LDL-lowering therapy. These exogenous lipids would be possible therapeutic targets in secondary prevention of CAD., Domestic conference

  Poster presentation


• Excessive intake of Trans-fatty acid accelerates thrombus formation in vivo through inhibiting endothelial anti-thrombogenic actions.

  近藤健介, 安田知之, 山本 順一郎, 門口倫子, 森 健太, 佐々木真希, 破磯川実, 原口英子, 中島英人, 篠原正和, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  The 77th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, Excessive intake of TFA accelerates the thrombus formation through inhibiting the anti-thrombogenic actions of endothelial cells.TFA would play an important role in the development of vascular diseases., Domestic conference

  Poster presentation


• Elevation of plasma BMPER levels in patients with coronary artery disease

  Kobayashi Seimi, Ishida Tatsuro, Hirata Ken-ichi, Rikitake Yoshiyuki

  第77回日本循環器学会総会, Mar. 2013, Japanese, 日本循環器学会, 横浜, BMPER levels were elevated in patients with coronary artery disease., Domestic conference

  Oral presentation


• Effect of overexpression of endothelial lipase on HDL metabolism and HDL anti-atherogenic properties in rabbits

  Tomoyuki Yasuda, Ishida Tatsuro, Kenta Mori, Hirata Ken-ichi

  The 77th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, uman EL reduced HDL-C and HDL anti-oxidative property in rabbits. Considering that lipid profile of rabbits resembles that of humans, alteration of EL expression or activity may improve HDL levels and anti-oxidant properties without affecting LDL-C levels, Domestic conference

  Oral presentation


• Endothelial Lipase would be a molecular target for HDL-raising therapy

  Ishida Tatsuro

  WINPTECH 2013, Feb. 2013, English, Integrated Research Center of Kobe University, 神戸, lasma EL mass and activity are determinants of plasma HDL-C levels, and correlated with risks in cardiovascular diseases. Because inhibition of plasma EL activity increased anti-inflammatory HDL particles, EL may represent a novel target for HDL-raising, International conference

  [Invited]

  Invited oral presentation


• Postprandial increases of circulating EL mass impact plasma HDL-C concentrations

  Ishida Tatsuro, Tomoyuki Yasuda, Hirata Ken-ichi, Kazuya Miyashita, Noriaki Kinoshita, Katsuyuki Nakajima, Kimber Stanhope, Peter J. Havel

  Scientific Sessions 2012 American Heart Assosiation, Nov. 2012, English, American Heart Assosiation, Los Angeles, Plasma EL mass is increased during postprandial conditions and this is associated with a decrease of circulating angtptl3 levels. The postprandial increase of EL mass was significantly correlated with the decrease of plasma HDL-C levels. Thus, EL action, International conference

  Poster presentation


• Increase in Exogenous Lipoproteins Characterized by Apolipoprotein B48 and Cholesterol Absorption/Synthesis Markers Represent Residual Risks for Coronary Artery Disease during Intensive LDL-Lowering Therapy

  Kenta Mori, Ishida Tatsuro, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Minoru Hasokawa, Hideto Nakajima, Yoko Haraguchi, Li Sun, Tomoyuki Yasuda, Hirata Ken-ichi

  Scientific Sessions 2012 American Heart Assosiation, Nov. 2012, English, American Heart Assosiation, Los Angeles, During the intensive lipid-lowering therapy by statins, cholesterol absorption predominates over cholesterol synthesis and serum apoB48 level is concomitantly increased, which leads to the progression of de novo lesions. Fasting apoB48 and cholesterol a, International conference

  Poster presentation


• Endothelial lipase in the heart modulates pressure overload-induced heart failure through fatty acid utilization

  Hideto Nakajima, Ishida Tatsuro, Michiko Monguchi, Maki Sasaki, Kensuke Kondo, Kenta Mori, Minoru Hasokawa, Yoko Haraguchi, Tomoyuki Yasuda, Toh Ryuji, Kobayashi Seimi, Hirata Ken-ichi

  Scientific Sessions 2012 American Heart Assosiation, Nov. 2012, English, American Heart Assosiation, Los Angeles, We have provided a novel finding that EL may be an alternative candidate to provide FA to the heart and regulate cardiac function. This effect seemed relevant particularly under the inflammatory condition where the action of LPL is downregulated., International conference

  Poster presentation


• 正常カロリーの高脂肪・フルクトース食によるWHHLMIウサギへのメタボリックシンドロームの誘導

  Shiomi Masashi, Tsutomu Kobayashi, Norihisa Nitta, Akinaga Sonoda, Kiyoshi Murata, Hirata Ken-ichi, Takashi Ito, Ishida Tatsuro

  5th Congress of Asian Federation of Laboratory Animal Science, Oct. 2012, English, Asian Federation of Laboratory Animal Science, Bangkok, Thailand, Objective: Cardiovascular disease (CVD) is a leading cause of death in the world and acute coronary syndromes (ACS) are the most important in it. However the mechanism of ACS are not clarified, because of no appropriate animal models. Therefore, we tried to develop an animal model for ACS using WHHLMI rabbits, which suffer from hypercholesterolemia and severe coronary atheroscl, International conference

  Poster presentation


• Comparision of Efficacy between Angiotensin II Receptor Blocker/Hydrochlorothiazide and Angiotensin II Receptor Blocker/Calcium Channel Blocker for Uncontrolled Hypertensive Patients

  近藤 健介, Ishida Tatsuro, Toh Ryuji, 安田 知行, Hirata Ken-ichi

  The 35th Annual Scientific Meeting of the Japanese Society of Hypertension, Sep. 2012, Japanese, Japanese Society of Hypertension, 名古屋, In comparision of telmisartan/HCTZ and telmisartan/amlodipine group , there were no significant differences in efficacy and safety after 12 weeks. In combination with ARB and diuretics, although we should care for increasing uric acid and aldosterone, thi, Domestic conference

  Poster presentation


• 冠動脈スパズムは、冠動脈病変の損傷、破綻を誘発する

  Shiomi Masashi, 小林 努, 新田 哲久, 園田 明永, 山田 悟士, 国吉 信恵, 村田 喜代史, Hirata Ken-ichi, 伊藤 隆, Ishida Tatsuro

  第1回ウサギバイオリサーチ研究会, Aug. 2012, Japanese, ウサギバイオリサーチ研究会, 宮崎, 【背景と目的】すべての不安定な冠動脈病変が破綻するわけではない。不安定病変に破綻をもたらす因子を明らかにすることは、急性冠症候群の病態の解明と予防法の開発に重要である。本研究では、高コレステロール血症と重度の冠動脈病変が自然発症するWHHLMIウサギに冠動脈スパズムを誘発し、冠動脈スパズムが冠動脈病変の傷害および破綻の原因になることを確認した。【方法】麻酔下でWHHLMIウサギ30匹に、ノルエピネフリン持続静注下にエルゴノビンを耳介周縁動脈から投与し、冠動脈スパズムを誘発した。スパズムの発生は、冠動脈造影と心電図で確認し、左心室の運動度をechocardiogramで評価し、血清中の心筋虚血マーカー（fatty acid binding protein (FABP), トロポニン―I, ミオグロビン）を測定した。実験終了後ウサギを安楽死し、生理食塩水, Domestic conference

  Oral presentation


• 冠動脈病変の破綻におけるMMP陽性マクロファージとスパズムの役割

  Shiomi Masashi, Ishida Tatsuro, 小林 努, 新田 哲久, 園田 明永, 國吉 信恵, 村田 喜代司, Hirata Ken-ichi, 伊藤 隆

  44th Annual Meeting of Japan Atherosclerosis Socienty, Jul. 2012, Japanese, Japan Atherosclerosis Socienty, 福岡, Purpose: We examined the role of MMP-positive macrophages and vasospasm in provocation of coronary plaque rupture using WHHLMI rabbits, an animal model of hypercholesterolemia and coronary atherosclerosis.Methods: Under anesthesia, coronary vasospasm was evoked in WHHLMI rabbits by intravenous injection of ergonovine during norepinephrine infusion. Provocation of coronary vasos, Domestic conference

  Public symposium


• Trans fatty acid is a modulator of serum lipoprotein metabolism and coronary artery disease in Japanese subjects

  破磯川 実, 篠原 正和, 門口 倫子, 佐々木 真希, 近藤 健介, 森 健太, 中島 英人, 原口 英子, 安田 知行, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  The 44th Annual Scientific Meeting of the Japan Atherosclerosis Society, Jul. 2012, Japanese, Japan Atherosclerosis Society, 福岡, Serum level of trans fatty acids was a predictor of coronary artery disease in Japanese patientns., Domestic conference

  Poster presentation


• Serum Myeloperoxidase/Paraoxonase 1 ratio is an independent predictor for recurrent stenosis after percutaneous coronary intervention through modulating quality of HDL

  原口 英子, Ishida Tatsuro, 門口 倫子, 佐々木 真希, 近藤 健介, 森 健太, 破磯川 実, 中島 英人, 安田 知行, Hirata Ken-ichi

  The 44th Annual Scientific Meeting of the Japan Atherosclerosis Society, Jul. 2012, Japanese, Japan Atherosclerosis Society, 福岡, Serum Myeloperoxidase/Paraoxonase 1 ratio was a predictor of recurrent stenosis after percutaneous coronary intervention through modulating quality of lipoproteins, Domestic conference

  Poster presentation


• Pitavastatin increases "functional" high density lipoprotein cholesterol in dyslipidemic patients

  佐々木 真希, 安田 知行, Ishida Tatsuro, 門口 倫子, 近藤 健介, 森 健太, 破磯川 実, 中島 英人, 原口 英子, Hirata Ken-ichi

  The 44th Annual Scientific Meeting of the Japan Atherosclerosis Society, Jul. 2012, Japanese, Japan Atherosclerosis Society, 福岡, Pitavastatin increased functional high density lipoprotein particles with anti-inflammatory properties in dyslipidemic patients, Domestic conference

  Poster presentation


• Generation of a high-sensitive and reliable ELISA system that can quantitatively measure human serum mass of endothelial lipase

  宮下かずや, Ishida Tatsuro, 安田知行, 孫麗, 木下憲明, 中嶋克行, Hirata Ken-ichi

  The 44th Annual Scientific Meeting of the Japan Atherosclerosis Society, Jul. 2012, Japanese, Japan Atherosclerosis Society, 福岡, We have generated a high-sensitive and reliable ELISA system that can quantitatively measure human serum mass of endothelial lipase., Domestic conference

  Poster presentation


• Fasting serum concentration of apolipoprotein B48 is a putative predictor of coronary risk in patients with coronary artery disease

  森 健太, Ishida Tatsuro, 門口 倫子, 佐々木 真希, 近藤 健介, 破磯川 実, 中島 英人, 原口 英子, Toh Ryuji, 安田 知行, 篠原 正和, 西村 邦弘, Hirata Ken-ichi

  The 44th Annual Scientific Meeting of the Japan Atherosclerosis Society, Jul. 2012, Japanese, Japan Atherosclerosis Society, 福岡, Fasting serum concentration of apolipoprotein B48 is a putative predictor of coronary risk in patients with coronary artery disease in Japanese subjects., Domestic conference

  Poster presentation


• Association of plasma concentration and enzymatic activity of endothelial lipase and coronary artery diseases.

  孫麗, Ishida Tatsuro, 森健太, 安田知行, 中島英人, 破磯川実, 原口英子, 佐々木真希, 近藤健介, Hirata Ken-ichi

  The 12th Annual Scientific Meeting of the NO Society of Japan, Jun. 2012, Japanese, The NO Society of Japan, 神戸, We measured protein concentration and enzymatic activity of endothelial lipase and investiaged the impacts on coronary artery diseases., Domestic conference

  Poster presentation


• Serum Myeloperoxidase/Paraoxonase 1 ratio affects recurrent stenosis after percutaneous coronary intervention through modulating quality of lipoproteins

  原口 英子, Ishida Tatsuro, 門口 倫子, 佐々木 真希, 近藤 健介, 森 健太, 破磯川 実, 中島 英人, 安田 知行, Hirata Ken-ichi

  The 12th Annual Scientific Meeting of the NO Society of Japan, Jun. 2012, Japanese, The NO Society of Japan, 神戸, Serum Myeloperoxidase/Paraoxonase 1 ratio was a predictor of recurrent stenosis after percutaneous coronary intervention through modulating quality of lipoproteins, Domestic conference

  Poster presentation


• Minimal residual disease monitoring in neuroblastoma patients by a set of real-time RT-PCR markers.

  Tanaka A, Hasegawa D, Hartomo TB, Ishida Tatsuro, Kawasaki K, Kosaka Y, Iijima Kazumoto, Matsuo M, Nishio Hisahide, Nishimura Noriyuki

  Advances in Neuroblastoma Research 2012 Conference, Jun. 2012, English, Tronto, Background: Minimal residual disease (MRD) is derived from tumor-initiating cells (TICs) consisting of only a small population of tumor, and its activation leads to tumor relapse. Because over 50% of high-risk neuroblastoma patients experience tumor relap, International conference

  Poster presentation


• Coronary Plaque Rupture, Relation of MMP-Positive Macrophages and Coronary Spasm

  Shiomi Masashi, Tsutomu Kobayashi, Norihisa Nitta, Akinaga Sonoda, Kiyoshi Murata, Hirata Ken-ichi, Takashi Ito, Ishida Tatsuro

  80th European Atherosclerosis Society Congress, May 2012, English, European Atherosclerosis Society, Milan, Italy, Object: In this study we examined how coronary vasospasm injures coronary atherosclerotic plaques using WHHLMI rabbits, an animal model for hypercholesterolemia, coronary atherosclerosis, and myocardial infarction.Methods: Coronary vasospasm was provoked in WHHLMI rabbits by intravenous injection of ergonovine during norepinephrine infusion. Provocation of coronary vasospasm w, International conference

  Poster presentation


• The Impact Of Paraoxonase 1 Activity On The Incidence Of Intra Stent Thrombus After Drug Eluting Stent Implantation In The 日本語 Cyp2c19 Loss Of Function Polymorphism Carriers

  Ryo Nishio, Shinke Toshiro, Otake Hiromasa, Yoko Haraguchi, Junya Shite, Hirata Ken-ichi, Ishida Tatsuro, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Junya Shite

  ACC12 i2, Mar. 2012, English, ACC12 i2, シカゴ, アメリカ, International conference

  Oral presentation


• Plasma mass and activity of endothelial lipase are associated with coronary risk factors in humans

  Ishida Tatsuro, Kenta Mori, Sun Li, Tomoyuki Yasuda, Hirata Ken-ichi

  The XVI International Symposium on Atherosclerosis (ISA2012), Mar. 2012, English, International Atherosclerosis Society, シドニー, オーストラリア, International conference

  Public symposium


• FGD5 Regulates VEGF-induced Pro-angiogenic Activities of Endothelial Cells

  Yusuke Kurogane, Miyata Muneaki, Yoshiki Kubo, Yoshiki Kubo, Yuichi Nagamatsu, Ishida Tatsuro, Ramendra K Kundu, Thomas Quertermous, Hirata Ken-ichi, Rikitake Yoshiyuki

  XVI International Symposium on Atherosclerosis (ISA2012), Mar. 2012, English, 国際動脈硬化学会, シドニー, オーストラリア, International conference

  Poster presentation


• Establishment of a novel, high-sensitive elisa system for human endothelial lipase

  Ishida Tatsuro, Miyashita K, Kinoshita N, Seito S, Hirata Ken-ichi, Nakajima K

  HDL Satellite symposium 2012, Mar. 2012, English, International Atherosclerosis Society, ケアンズ, オーストラリア, International conference

  Poster presentation


• Cholesterol Absorption and Synthesis Markers Predict Atherosclerotic Lesion Progression in Patients with Coronary Artery Disease

  Kenta Mori, Ishida Tatsuro, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Minoru Hasokawa, Hideto Nakajima, Yoko Haraguchi, Sun Li, Toh Ryuji, Tomoyuki Yasuda, Masakazu Shinohara, Kunihiro Nishimura, Hirata Ken-ichi

  The XVI International Symposium on Atherosclerosis (ISA2012), Mar. 2012, English, International Atherosclerosis Society, シドニー, オーストラリア, International conference

  Poster presentation


• Cholesterol Absorption/Synthesis Markers Modulate the Progression of Coronary Atherosclerotic Lesions

  Kenta Mori, Ishida Tatsuro, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Minoru Hasokawa, Hideto Nakajima, Yoko Haraguchi, Toh Ryuji, Tomoyuki Yasuda, Masakazu Shinohara, Kunihiro Nishimura, Hirata Ken-ichi

  第76回日本循環器学​会学術集会, Mar. 2012, Japanese, 日本循環器学会, 福岡, Domestic conference

  Poster presentation


• Cardiac endothelial lipase expression is augmented in the early stage of heart failure

  Hideto Nakajima, Ishida Tatsuro, Tomoko monguchi, Kensuke Kondo, Kenta Mori, Maki Sasaki, Minoru Hasokawa, Yoko Haraguchi, Tomoyuki Yasuda, Kobayashi Seimi, Hirata Ken-ichi

  The XVI International Symposium on Atherosclerosis (ISA2012), Mar. 2012, English, The Australian Atherosclerosis Society, シドニー, オーストラリア, International conference

  Poster presentation


• Cardiac Endothelial Lipase Expression is Augmented in a Murine Model of Heart Failure

  Hideto Nakajima, Ishida Tatsuro, Tomoko monguchi, Kensuke Kondo, Kenta Mori, Maki Sasaki, Minoru Hasokawa, Yoko Haraguchi, Tomoyuki Yasuda, Kobayashi Seimi, Hirata Ken-ichi

  日本循環器学会学術集会, Mar. 2012, Japanese, 日本循環器学会, 福岡, Domestic conference

  Oral presentation


• Fasting Apolipoprotein B48 is a Novel Marker for Residual Risks in Coronary Artery Disease During Intensive LDL-Lowering Therapy

  Kenta Mori, Ishida Tatsuro, Maki Sasaki, Kensuke Kondo, Yoko Haraguchi, Minoru Hasokawa, Hideto Nakajima, Sun Li, Toh Ryuji, Tomoyuki Yasuda, Masakazu Shinohara, Kunihiro Nishimura, Hirata Ken-ichi

  American Heart Association Scientific Session, Nov. 2011, English, American Heart Association, オーランド, アメリカ, International conference

  Oral presentation


• Role of dyslipidemia in diabetic vascular diseases

  Ishida Tatsuro, Hirata Ken-ichi

  第26回日本糖尿病合併症学会総会, Oct. 2011, Japanese, 日本糖尿病合併症学会, 大宮, Domestic conference

  [Invited]

  Invited oral presentation


• Efficacy of medium-dose losartan/hydrochlorothiazide or maximal-dose angiotensin II receptor blockers for uncontrolled hypertensive patients; The Kobe-CONNECT Study

  Ishida Tatsuro, Toh Ryuji, 江本憲昭, Hirata Ken-ichi

  第34回日本高血圧学会総会, Oct. 2011, Japanese, 日本高血圧学会, 宇都宮, Domestic conference

  Poster presentation


• CORONARY SPASM INJURES CORONARY LESIONS OF WHHLMI RABBITS.

  Kobayashi Takashi, Ito T, Ishida Tatsuro, Nitta N, Sonoda A, Kuniyoshi N, Yamada S, Murata K, Hirata Ken-ichi, Shiomi Masashi

  9th International Congress on Coronary Artery Disease, Oct. 2011, English, Venice, Italy, International conference

  Poster presentation


• Regulation of VEGF-induced Pro-angiogenic Activities of Endothelial Cells by FGD5

  Yusuke Kurogane, Rikitake Yoshiyuki, Ishida Tatsuro, Hirata Ken-ichi

  第75回日本循環器学会総会・学術集会, Aug. 2011, English, 日本循環器学会, 横浜, Domestic conference

  Oral presentation


• Involvement of NFkB in BMPER-induced Osteogenic Differentiation of Human Coronary Artery Smooth Muscle Cells

  Kobayashi Seimi, Rikitake Yoshiyuki, Mitsuo Kinugasa, Mitsuo Kinugasa, Ishida Tatsuro, Noriaki Emoto, Noriaki Emoto, Hirata Ken-ichi

  第75回日本循環器学会総会・学術集会, Aug. 2011, English, 日本循環器学会, 横浜, Domestic conference

  Oral presentation


• Increased expression of endothelial lipase in a murine model of heart failure

  中島英人, Ishida Tatsuro, 近藤健介, 森健太, 佐々木真希, 破磯川実, 原口英子, 安田知行, 篠原正和, Kobayashi Seimi, Hirata Ken-ichi

  第43回日本動脈硬化学会総会・学術集会, Jul. 2011, Japanese, 日本動脈硬化学会, 札幌, Domestic conference

  Poster presentation


• FGD5 Regulates VEGF-induced Pro-angiogenic Activities of Endothelial Cells

  Yusuke Kurogane, Rikitake Yoshiyuki, Miyata Muneaki, Yoshiki Kubo, Yuichi Nagamatsu, Ishida Tatsuro, Thomas Quertermous, Hirata Ken-ichi

  第43回日本動脈硬化学会総会・学術集会, Jul. 2011, Japanese, 日本動脈硬化学会, 札幌, Domestic conference

  Poster presentation


• Developement of an Animal Model for coronary spastic angina

  Kobayashi Takashi, Ishida Tatsuro, Nitta N, Sonoda A, Kobayashi S, Ito T, Murata K, Hirata Ken-ichi, Shiomi Masashi

  The 43rd Annual Scientific Meeting of the Japanese Atherosclerosis Society., Jul. 2011, Japanese, 日本動脈硬化学会, 札幌, Domestic conference

  Poster presentation


• BMPER Induced Osteogenic Differentiation in Human Coronary Artery Smooth Muscle Cells via NFkB Activation

  Kobayashi Seimi, Rikitake Yoshiyuki, Mitsuo Kinugasa, Mitsuo Kinugasa, Ishida Tatsuro, Noriaki Emoto, Noriaki Emoto, Hirata Ken-ichi

  第43回日本動脈硬化学会総会・学術集会, Jul. 2011, Japanese, 日本動脈硬化学会, 札幌, Domestic conference

  Poster presentation


• WHHLMI Rabbits with Coronary Lesions are a good Animal Model for Coronary Spastic Angina

  Kobayashi Takashi, Ishida Tatsuro, Nitta N, Sonoda A, Ito T, Kuniyoshi-Hirayama N, Yamada S, Kobayashi S, Miyagawa K, Murata K, Hirata Ken-ichi, Shiomi Masashi

  4th International Rabbit Biotechnology Meeting, Jun. 2011, English, Agricultural Biotechnology Center, Hungary, Budapest, Humgary, International conference

  Poster presentation


• Role of endothelial lipase in HDL metabolism and atherosclerosis in humans.

  Ishida Tatsuro, Toh Ryuji, Li Sun, Tomoyuki Yasuda, Hirata Ken-ichi

  第43回日本動脈硬化学会総会・学術集会, Jun. 2011, English, 欧州動脈硬化学会, ヨーテボリ, スウェーデン, International conference

  Public symposium


• Oral administration of an active form vitamin D3 (calcitriol) decreases atherosclerosis in mice via inducing regulatory T cells and immature dendritic cells with tolerogenic functions.

  Yamashita Tomoya, Masafumi Takeda, Sasaki Naoto, Kenji Nakajima, Tomoyuki Kita, Masakazu Shinohara, Ishida Tatsuro, Hirata Ken-ichi

  Arteriosclerosis, Thrombosis,and Vascular Biology 2011, Apr. 2011, English, American Heart Association, シカゴ, 米国, International conference

  [Invited]

  Invited oral presentation


• Regulation of VEGF-induced Pro-angiogenic Activities of Endothelial Cells by FGD5

  Yusuke Kurogane, Rikitake Yoshiyuki, Ishida Tatsuro, Hirata Ken-ichi

  第75回日本循環器学会総会・学術集会, Mar. 2011, English, 日本循環器学会, 横浜, Domestic conference

  Oral presentation


• Involvement of NFkB in BMPER-induced Osteogenic Differentiation of Human Coronary Artery Smooth Muscle Cells

  Kobayashi Seimi, Rikitake Yoshiyuki, Mitsuo Kinugasa, Ishida Tatsuro, Noriaki Emoto, Hirata Ken-ichi

  第75回日本循環器学会総会・学術集会, Mar. 2011, English, 日本循環器学会, 横浜, Domestic conference

  Oral presentation


• Hypertriglycemia lowers plasma HDL-C levels and generates “dysfunctional HDL” in mice

  安田知行, Ishida Tatsuro, Thomas P. Johnston, 井上通彦, Hirata Ken-ichi

  第75回日本循環器学会総会, Mar. 2011, English, 日本循環器学会, 横浜, Domestic conference

  Oral presentation


• GasChromatography-MassSpectrometry (GC-MS) based Hydrophilic Metabolomics analysis of the serum in Patients with Coronary Artery Diseases (CAD)

  破磯川実, 篠原正和, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  第75回日本循環器学会総会, Mar. 2011, English, 日本循環器学会, 横浜, Domestic conference

  Poster presentation


• 長期に経過を観察し、ステロイド中止により再燃した慢性心筋炎の一例

  永松裕一, Yamashita Tomoya, 漁 恵子, 松田康章, Ishida Tatsuro, Yoshida Akihiro, 志手淳也, 川合宏哉, Hirata Ken-ichi

  第110回日本循環器学会近畿地方会, Nov. 2010, Japanese, 日本循環器学会, 京都, Domestic conference

  Oral presentation


• The WHHLMI Rabbit as a Model Animal for Coronary Spastic Angina.

  小林 努, Ishida Tatsuro, 新田 哲久, 園田 明永, 伊藤 隆, 平山 信恵, 山田 悟士, Kobayashi Seimi, 宮川 一也, 村田 喜代史, Hirata Ken-ichi, Shiomi Masashi

  4th Congress of Asian Federation of Laboratory Animal Science, Nov. 2010, English, Asian Federation of Laboratory Animal Science, Taipei, Taipei International Congress Center (Taiwan), International conference

  Poster presentation


• Serum myeloperoxidase/paraoxonase 1 ratio is an independent predictor for repeat revascularization after percutaneous coronary intervention.

  原口英子, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  Scientific Sessions 2010 American Heart Association., Nov. 2010, English, American Heart Association, シカゴ, アメリカ, International conference

  Poster presentation


• Usefulness of myeloperoxidase and paraoxonase1 as a serum marker for second prevention of coronary artery diseases.

  原口 英子, Toh Ryuji, 破磯川 実, 中島 英人, 本庄 友行, 乙井 一典, 西村 邦宏, Ishida Tatsuro, Hirata Ken-ichi

  第33回日本高血圧学会, Oct. 2010, Japanese, 日本高血圧学会, 福岡, Domestic conference

  Oral presentation


• Serum myeloperoxidase level is an independent predictor for stent-restenosis in states of well-controlled low-density lipoprotein cholesterol level

  破磯川 実, Toh Ryuji, 原口 英子, 中島 英人, 本庄 友行, 乙井 一典, 西村 邦宏, Ishida Tatsuro, Hirata Ken-ichi

  第42回日本動脈硬化学会, Oct. 2010, Japanese, 日本高血圧学会, 福岡, Domestic conference

  Oral presentation


• 不安定狭心症のモデル動物としてのWHHLMIウサギの有用性。

  小林 努, Ishida Tatsuro, 新田 哲久, 園田 明永, 伊藤 隆, 平山 信恵, 山田 悟士, Kobayashi Seimi, 宮川 和也, 村田 喜代史, Hirata Ken-ichi, Shiomi Masashi

  第4回ウサギフォーラム, Jul. 2010, Japanese, ウサギフォーラム, 秋田, 秋田大学 (日本), Domestic conference

  Oral presentation


• The WHHLMI Rabbit Is a Suitable Animal Model for Human Unstable Angina.

  小林 努, Ishida Tatsuro, 宮川 和也, 平山 信恵, 山田 悟士, 伊藤 隆, Hirata Ken-ichi, Shiomi Masashi

  第42回日本動脈硬化学会総会., Jul. 2010, Japanese, 日本動脈硬化学, 岐阜, 長良川国際会議場 (日本), Domestic conference

  Poster presentation


• Plasma EL activity is a regulator of plasma HDL-cholesterol level and a target for HDL-raising therapies

  Ishida Tatsuro, 孫 麗, Toh Ryuji, Hirata Ken-ichi

  第42回日本動脈硬化学会, Jul. 2010, Japanese, 日本高血圧学会, 福岡, Domestic conference

  Public symposium


• WHHLMI rabbit is an animal model for angina and/or coronary spasms.

  小林 努, 伊藤 隆, 山田 悟士, 平山 信恵, Hirata Ken-ichi, Ishida Tatsuro, Shiomi Masashi

  78th European Atherosclerosis Society Congress,, Jun. 2010, English, European Atherosclerosis Society, Hamburg, Congress Center Hamburg (Germany), International conference

  Poster presentation


• The WHHLMI Rabbit Is a Suitable Animal Model for Human Unstable Angina.

  小林 努, Ishida Tatsuro, 平山 信恵, 山田 悟士, 伊藤 隆, Hirata Ken-ichi, Shiomi Masashi

  第57回日本実験動物学会総会, May 2010, Japanese, 日本実験動物学会, 京都, 京都テルサ (日本), Domestic conference

  Poster presentation


• 冠動脈疾患二次予防の血清バイオマーカーとしてのMyeloperoxidaseおよびParaoxonase 1の有用性.

  原口英子, Toh Ryuji, 破磯川実, 中島英人, 本庄友行, 乙井一典, 西村邦宏, Ishida Tatsuro, Hirata Ken-ichi

  第33回日本高血圧学会総会, Apr. 2010, Japanese, 日本高血圧学会, 福岡, Domestic conference

  Oral presentation


• Serum Myeloperoxidase Level is an Independent Predictor for Stent-restenosis

  Toh Ryuji, Nishimura Kunihiro, Ishida Tatsuro, Hirata Kenichi

  第74回 日本循環器学会総会・学術集会（JCS2010）, Mar. 2010, English, 日本循環器学会, 京都, Domestic conference

  Oral presentation


• Plasma EL activity is inversely correlated with the HDL-cholesterol level in humans

  Ishida Tatsuro, Toh Ryuji, Hirata Kenichi

  第74回 日本循環器学会総会・学術集会（JCS2010）, Mar. 2010, English, 日本循環器学会, 京都, Domestic conference

  Oral presentation


• BMP binding endothelial regulator (BMPER) is a novel regulator of human coronary artery calcification

  Kobayashi Seimi, Rikitake Yoshiyuki, Ishida Tatsuro, Emoto Noriaki, Hirata Kenichi

  第74回日本循環器学会総会, Mar. 2010, English, 日本循環器学会, 京都, Domestic conference

  Oral presentation


• Inactivation of endothelial lipase increases anti-inflammatory HDL particles.

  原哲也, Ishida Tatsuro, 児島陽子, Hirata Kenichi

  Scientific Sessions 2009 American Heart Association, Nov. 2009, English, American Heart Association, オーランド, アメリカ, International conference

  Oral presentation


• Inhibition of endothelial lipase can raise anti-atherogenic HDL particles

  Ishida Tatsuro, Yasuda Tomoyuki, Hirata Kenichi

  第41回日本動脈硬化学会総会•学術集会, Jul. 2009, Japanese, 日本動脈硬化学会, 下関, Domestic conference

  Public symposium


• 大動脈弁閉鎖不全症を伴った大動脈炎症候群の一例

  Ishida Tatsuro, Kawai Hiroya, Hirata Kenichi, Hayashi Hiroki, Tsuji Goh

  日本循環器学会 第107回近畿地方会, Jun. 2009, Japanese, 日本循環器学会, 大阪, Domestic conference

  Oral presentation


• 抗精神病薬治療中に発症した慢性心筋炎の一剖検例

  Toh Ryuji, Ishida Tatsuro, Yoshida Akihiro, Shite Junya, Kawai Hiroya, Hirata Kenichi

  日本循環器学会 第106回近畿地方会, Nov. 2008, Japanese, 日本循環器学会, 神戸, Domestic conference

  Oral presentation


• Targeted Deletion Of Endothelial Lipase Protects Against Allergic Asthma Through Raising Plasma HDL Level And Attenuating Eosinophil Infiltration

  Ishida Tatsuro, Yasuda Tomoyuki, Nishimura Yoshihiro, Hirata Kenichi

  アメリカ心臓病学会2008, Nov. 2008, English, アメリカ心臓病学会, ニューオリンズ, アメリカ, International conference

  Poster presentation


• Targetd inactivation of receptor for advanced glycation products reduced oxidative LDL-induced inflammation and atherosclerosis in non-diabetic LDL receptor-/- mice

  Ishida Tatsuro, Yasuda Tomoyuki, Hirata Kenichi, Hayashi Yoshitake

  アメリカ心臓病学会2008, Nov. 2008, English, アメリカ心臓病学会, ニューオリンズ, アメリカ, International conference

  Poster presentation


• Role of endothelial cell-selective adhesion molecule in the progression of atherosclerosis

  Ishida Tatsuro, Hirata Kenichi

  アメリカ心臓病学会2008, Nov. 2008, English, アメリカ心臓病学会, ニューオリンズ, アメリカ, International conference

  Oral presentation


• Effect of pitavastatin on serum concentrations of endothelial lipase and high-density lipoprotein cholesterol in humans.

  Ishida Tatsuro, Yasuda Tomoyuki, Hirata Kenichi

  アメリカ心臓病学会2008, Nov. 2008, English, アメリカ心臓病学会, ニューオリンズ, アメリカ, International conference

  Oral presentation


• CPAより蘇生に成功し、ICD植込みを行った冠攣縮性狭心症の一症例

  Yamashita Tomoya, Ishida Tatsuro, Yoshida Akihiro, Shite Junya, Kawai Hiroya, Hirata Kenichi

  日本循環器学会 第106回近畿地方会, Nov. 2008, Japanese, 日本循環器学会, 神戸, Domestic conference

  Oral presentation


• 大動脈炎症候群に伴う血管病変が原因と考えられた肺高血圧の１例

  Toh Ryuji, Ishida Tatsuro, Kawai Hiroya, Emoto Noriaki, Hirata Kenichi, Tsuji Goh, Kumagai Shunichi

  日本内科学会 第186回近畿地方会, Sep. 2008, Japanese, 日本内科学会, 京都, Domestic conference

  Oral presentation


• 心臓再同期療法を施行した心ファブリー病の一例

  Kawai Hiroya, Fukuzawa Koji, Ishida Tatsuro, Yoshida Akihiro, Hirata Kenichi

  日本心臓病学会 第56回学術集会, Sep. 2008, Japanese, 日本心臓病学会, 東京, Domestic conference

  Poster presentation


• role of endothelial cell-selective adhesion molecule (ESAM) in atherogenesis

  Ishida Tatsuro, Hirata Kenichi

  第40回日本動脈硬化学会総会•学術集会, Jul. 2008, Japanese, 日本動脈硬化学会, つくば, Domestic conference

  Poster presentation


• 家兎における血管内皮リパーゼの過剰発現が血清脂質に及ぼす影響

  Ishida Tatsuro, Yasuda Tomoyuki, Hirata Kenichi

  第３回ウサギフォーラム, Jul. 2008, Japanese, ウサギフォーラム, 神戸, Domestic conference

  Oral presentation


• マウスマクロファージ細胞における超低比重リポタンパク (VLDL)受容体発現の欠如ーヒトおよびウサギ動脈硬化巣との相違ー

  Ito Takashi, Sasaki Naoto, Ishida Tatsuro, Hirata Kenichi, Shiomi Masashi

  第３回ウサギフォーラムー医療に貢献する実験用ウサギの新しい展開, Jul. 2008, Japanese, ウサギフォーラム, 神戸, Domestic conference

  Oral presentation


• Role of endothelial lipase in the HDL-raising effects of statins

  Ishida Tatsuro, Yasuda Tomoyuki, Hirata Kenichi

  第40回日本動脈硬化学会総会•学術集会, Jul. 2008, Japanese, 日本動脈硬化学会, つくば, Domestic conference

  Public symposium


• 心臓再同期療法を施行し術直後より左室拡張能の改善を認めた心ファブリー病の一例

  Fukuzawa Koji, Ishida Tatsuro, Yoshida Akihiro, Kawai Hiroya, Hirata Kenichi

  日本循環器学会 第105回近畿地方会, Jun. 2008, Japanese, 日本循環器学会, 大阪, Domestic conference

  Oral presentation


• 血管内皮リパーゼの血中濃度と血清HDL値との関係

  Ishida Tatsuro, Yasuda Tomoyuki, Hirata Kenichi

  第105回 内科学会講演会, Apr. 2008, Japanese, 日本内科学会, 東京, Domestic conference

  Poster presentation


• Role of endothelial cell-selective adhesion molecule (ESAM) in tumor angiogenesis and metastasis

  Ishida Tatsuro, Yasuda Tomoyuki, Hayashi Yoshitake, Hirata Kenichi

  第72回日本循環器学会総会・学術総会, Mar. 2008, English, 日本循環器学会, 福岡, Domestic conference

  Oral presentation


• RAGE Deficiency Inhibit the Atherosclerosis Progression in now diabetic Low-Density Lipoprotein Receptor Knockout Mice

  Ishida Tatsuro, Yasuda Tomoyuki, Hayashi Yoshitake, Hirata Kenichi

  第72回日本循環器学会総会・学術総会, Mar. 2008, English, 日本循環器学会, 福岡, Domestic conference

  Poster presentation


• High glucose stimulation reduced endothelial cell-selective adhesion molecule (ESAM) expression: a potential role in albuminuria in diabetic microangiopaty

  Ishida Tatsuro, Yasuda Tomoyuki, Hirata Kenichi

  第72回日本循環器学会総会・学術総会, Mar. 2008, Japanese, 日本循環器学会, 福岡, Domestic conference

  Poster presentation


• Endothelial lipase selectively regulates HDL metabolism in rabbits

  Yasuda Tomoyuki, Ishida Tatsuro, Hirata Kenichi

  第72回日本循環器学会総会・学術総会, Mar. 2008, English, 日本循環器学会, 福岡, Domestic conference

  Oral presentation


• Endothelial lipase regulates postprandial hypertriglyceridemia

  Ishida Tatsuro, Yasuda Tomoyuki, Hirata Kenichi

  第72回日本循環器学会総会・学術総会, Mar. 2008, English, 日本循環器学会, 福岡, Domestic conference

  Poster presentation


• ウサギ内皮リパーゼの同定及び組織発現についての検討

  YU Ying, 張 継峰, KOIKE TOMONARI, 範 江林, ISHIDA TATSURO, HIRATA KENICHI

  第3回ウサギフォーラム, 2008, Japanese, Domestic conference

  Poster presentation


• Overexpression of endothelial lipase in the liver promotes the clearance of plasma lipids but accelerates liver steatosis in a mouse model of metabolic syndrome

  Yasuda Tomoyuki, Ishida Tatsuro, Hirata Kenichi

  第７9回AmericanHeartAssociationScientificSession, Nov. 2007, English, The American Heart Association, Orland, アメリカ, International conference

  Oral presentation


• Endothelial Lipase Knock Out mouseにおけるNASH（非アルコール性脂肪性肝炎）の病態解析

  Miki Akira, Yano Yoshihiko, Seo Yasushi, Azuma Takeshi, Yasuda Tomoyuki, Ishida Tatsuro, Hirata Kenichi, Hayashi Yoshitake

  第４９回日本消化器病学会大会, Oct. 2007, Japanese, 日本消化器病学会, 神戸, Domestic conference

  Oral presentation


• LDL receptor upregulation during inflammation promotes the uptake of triglyceride-rich lipoproteins in macrophages

  Yasuda Tomoyuki, Ishida Tatsuro, Hirata Kenichi

  第39回日本動脈硬化学会総会・学術集会, Jul. 2007, Japanese, 日本動脈硬化学会, 大阪, Domestic conference

  Poster presentation


• 化学療法が著効した心臓原発悪性リンパ腫の１例

  Tanaka Hidekazu, Ishida Tatsuro, Yoshida Akihiro, Kawai Hiroya, Hirata Kenichi, Yokoyama Mitsuhiro

  第182回日本内科学会近畿地方会, May 2007, Japanese, 日本内科学会, 大阪, Domestic conference

  Oral presentation


• The Role of Endothelial Lipase in HDL Metabolism and Atherosclerosis: A New Therapeutic Target for Raising HDL-Cholesterol

  HIRATA KENICHI, Ishida Tatsuro, Yokoyama Mitsuhiro

  第7１回日本循環器学会総会・学術集会, Mar. 2007, English, 日本循環器学会, 神戸, Domestic conference

  [Invited]

  Invited oral presentation


• Targeted inactivation of endothelial cell-selective adhesion molecule inhibits susceptibility to atherosclerosis in apoprotein-E-deficient mice.

  HIRATA KENICHI, Ishida Tatsuro, Yokoyama Mitsuhiro

  第7１回日本循環器学会総会・学術集会, Mar. 2007, English, 日本循環器学会, 神戸, Domestic conference

  Oral presentation


• Over-expression of endothelial lipase in the liver promoted the clearance of plasma lipids and induced steatosis in a mouse model of metabolic syndrome

  HIRATA KENICHI, Ishida Tatsuro, Yokoyama Mitsuhiro

  第7１回日本循環器学会総会・学術集会, Mar. 2007, English, 日本循環器学会, 神戸, Domestic conference

  Oral presentation


• Endothelial lipase is increased by inflammation and promotes LDL uptake in macrophages.

  HIRATA KENICHI, Ishida Tatsuro, Yokoyama Mitsuhiro

  第7１回日本循環器学会総会・学術集会, Mar. 2007, English, 日本循環器学会, 神戸, Domestic conference

  Poster presentation


• EL Overexpression in the Vessel Wall doesn't Affect Atherosclerotic Lesion Formation in ApoE-KO mice

  HIRATA KENICHI, Ishida Tatsuro, Yokoyama Mitsuhiro

  第7１回日本循環器学会総会・学術集会, Mar. 2007, Japanese, 日本循環器学会, 神戸, Domestic conference

  Poster presentation


• 脂質、糖代謝における血管内皮リパーゼ（EL）の役割

  HIRATA KENICHI, Ishida Tatsuro, Yokoyama Mitsuhiro

  第38回 日本動脈硬化学会, Jul. 2006, Japanese, 日本動脈硬化学会, 東京, Domestic conference

  Poster presentation


• Simvastatin inhibits LPS-induced LDL uptake through suppression of EL expression in macrophages.

  HIRATA KENICHI, Ishida Tatsuro, Yokoyama Mitsuhiro

  14th International Symposium on Atherosclerosis, Jun. 2006, English, International Society of Atherosclerosis, Roma, International conference

  Poster presentation


• Role of Endothelial Lipase in Low Serum High-Density Lipoprotein (HDL) Level Associated with Hypertriglyceridemia

  Ishida Tatsuro, HIRATA KENICHI, Yokoyama Mitsuhiro

  第79回米国心臓協会学術集会, Jun. 2006, English, 米国心臓協会, シカゴ, International conference

  Oral presentation


• Endothelial lipase modulates lesion formation in mouse model of vascular remodeling

  HIRATA KENICHI, Ishida Tatsuro, Yokoyama Mitsuhiro

  第79回米国心臓協会学術集会, Jun. 2006, English, 米国心臓協会, シカゴ, International conference

  Poster presentation


• 血管内皮リパーゼはマウス血管リモデリング形成を制御する。

  岡田 武哲, HIRATA, Kenichi, ISHIDA, Tatsuro, 児島 陽子, 安田 知行, 田中 華代, 平 和樹, YOKOYAMA, Mitsuhiro

  日本脈管学会（第４６回）, Dec. 2005, Japanese, 日本脈管学会, 大阪, Domestic conference

  Oral presentation


• Role of endothelial lipase in HDL metabolism and atherosclerosis

  ISHIDA, Tatsuro

  Youngnam Intervention Meeting, Dec. 2005, English, プサン, International conference

  Oral presentation


• Xenogenic Smooth Muscle Cell Immunization Reduces Neointimal Formation in Balloon-Injured Rabbit Carotid Arteries

  Masakazu Shinohara, KAWASHIMA, Seinosuke, YAMASHITA,Tomoya, Tomofumi Takaya, Ryuji Toh, ISHIDA, Tatsuro, Tomomi Ueyama, INOUE,Nobutaka, Ken-ichi Hirata, YOKOYAMA, Mitsuhiro

  第７8回American Heart Association Scientific Session, Nov. 2005, English, American Heart Association, ダラス, International conference

  Oral presentation


• 高中性脂肪血症にともなう低HDL血症における血管内皮リパーゼの役割

  田中 華代, HIRATA, Kenichi, ISHIDA, Tatsuro, 児島 陽子, 安田 知行, 岡田 武哲, 平 和樹, YOKOYAMA, Mitsuhiro

  日本動脈硬化学会総会（第37回）, Jul. 2005, Japanese, 日本動脈硬化学会, 東京, Domestic conference

  Poster presentation


• Endothelial lipase deficiency increased plasma cholesterol but reduced susceptibility to atherosclerosis in apoE deficient mice

  ISHIDA, Tatsuro, Ken-ichi Hirata, Yoko Kojima, Thomas Quertermous, YOKOYAMA, Mitsuhiro

  European Atherosclerosis Society 75th Congress, Apr. 2005, English, プラハ, International conference

  Poster presentation


• 血管細胞とマクロファージの接着における血管内皮リパーゼの役割

  児島 陽子, HIRATA, Kenichi, ISHIDA, Tatsuro, INOUE,Nobutaka, KAWASHIMA, Seinosuke, YOKOYAMA, Mitsuhiro

  第34回心脈管作動物質学会, Feb. 2005, Japanese, 京都, Domestic conference

  Oral presentation


• Endothelial lipase遺伝子多型は急性心筋梗塞の発症と関連する

  清水 政克, KANAZAWA, Kenji, HIRATA, Kenichi, ISHIDA, Tatsuro, 松田 康章, MIYAMOTO, Yoshitomo, AKITA, Hozuka, YOKOYAMA, Mitsuhiro

  第34回 日本心脈管作動物質学会, Feb. 2005, Japanese, 日本心脈管作動物質学会, 京都, Domestic conference

  [Invited]

  Invited oral presentation


• 血管細胞とマクロファージの接着における血管内皮リパーゼの役割

  児島 陽子, HIRATA, Kenichi, ISHIDA, Tatsuro, INOUE,Nobutaka, KAWASHIMA, Seinosuke, YOKOYAMA, Mitsuhiro

  第45回日本脈管学会総会, Oct. 2004, Japanese, 日本脈管学会, 札幌, Domestic conference

  Oral presentation


• スタチンによる血管内皮リパーゼの発現調節

  児島 陽子, HIRATA, Kenichi, ISHIDA, Tatsuro, INOUE,Nobutaka, KAWASHIMA, Seinosuke, YOKOYAMA, Mitsuhiro

  第36回日本動脈硬化学会総会, Jul. 2004, Japanese, 日本動脈硬化学会, 福岡, Domestic conference

  Oral presentation


• Identification of non-secreted endothelial cell-derived lipase (EDL) isoforms in human endothelial cells

  ISHIDA, Tatsuro, HIRATA, Kenichi, 児島 陽子, Thomas Quertermous, KAWASHIMA, Seinosuke, YOKOYAMA, Mitsuhiro

  第68回日本循環器学会総会・学術集会, Mar. 2004, Japanese, 日本循環器学会, 東京, Domestic conference

  Oral presentation


• Targeted Deletion of Endothelial Cell-Selective Adhesion Molecule Attenuate Monocyte-Endothelial Cell Adhesion Both In Vitro and In Vivo

  ISHIDA, Tatsuro, Thomas Quertermous

  第７６回American Heart Association Scientific Session, Nov. 2003, English, American Heart Association, オーランド, International conference

  Oral presentation


• 全身性炎症におけるマクロファージと血管細胞との接着における内皮由来リパーゼの役割

  児島 陽子, HIRATA, Kenichi, ISHIDA, Tatsuro, 岩井 健二, 下川 泰史, INOUE,Nobutaka, KAWASHIMA, Seinosuke, YOKOYAMA, Mitsuhiro

  第35回日本動脈硬化学会, Sep. 2003, Japanese, 日本動脈硬化学会, 京都, Domestic conference

  Poster presentation


• 若手企画モーニングセミナー 血管内皮リパーゼの病的血管壁での発現制御とその機能

  ISHIDA, Tatsuro, HIRATA, Kenichi, 児島 陽子, 岩井 健二, YOKOYAMA, Mitsuhiro

  第35回日本動脈硬化学会, Sep. 2003, Japanese, 日本動脈硬化学会, 京都, Domestic conference

  Oral presentation


• 孤立性心筋内転移をきたした子宮頸癌の一例

  田村 勇, ISHIDA, Tatsuro, INOUE,Nobutaka, KAWAI, Hiroya, 田中 秀和, 上田 亮介, KAWASHIMA, Seinosuke, YOKOYAMA, Mitsuhiro

  第171回日本内科学会近畿地方会, Sep. 2003, Japanese, 日本内科学会, 大阪, Domestic conference

  Oral presentation


• 血管壁細胞におけるリゾフォスファチジルコリン受容体の発現と機能

  岩井 健二, HIRATA, Kenichi, RIKITAKE, Yoshiyuki, ISHIDA, Tatsuro, 児島 陽子, 下川 泰史, 平瀬 徹明, INOUE,Nobutaka, KAWASHIMA, Seinosuke, YOKOYAMA, Mitsuhiro

  第35回日本動脈硬化学会, Sep. 2003, Japanese, 日本動脈硬化学会, 京都, Domestic conference

  Poster presentation


• ラット内皮由来リパーゼのクローニングと高血圧モデルラットにおける発現制御

  下川 泰史, HIRATA, Kenichi, ISHIDA, Tatsuro, 児島 陽子, 岩井 健二, 平瀬 徹明, INOUE,Nobutaka, KAWASHIMA, Seinosuke, YOKOYAMA, Mitsuhiro

  第35回日本動脈硬化学会, Sep. 2003, Japanese, 日本動脈硬化学会, 京都, Domestic conference

  Poster presentation


• シンポジウム 血管内皮リパーゼは血清HDLコレステロール値の主要な規定因子である

  HIRATA, Kenichi, ISHIDA, Tatsuro, 児島 陽子, 平瀬 徹明, INOUE,Nobutaka, KAWASHIMA, Seinosuke, YOKOYAMA, Mitsuhiro

  第35回日本動脈硬化学会, Sep. 2003, Japanese, 日本動脈硬化学会, 京都, Domestic conference

  Oral presentation


• Alterd expression of endothelial cell-derived lipase in diseased vessel wall and its impact on HDL metabolism

  ISHIDA, Tatsuro, Ken-ichi Hirata, Yoko Kojima, Choi S, A Cooper, Thomas Quertermous, YOKOYAMA, Mitsuhiro

  第１３回国際動脈硬化学会学術会議, Sep. 2003, English, 国際動脈硬化学会, 京都, International conference

  Oral presentation

• Japan Atherosclerosis Society

  Apr. 2003 - Present


• Japanese Society of Internal Medicine

  Aug. 1990 - Present


• Japanese Circulation Society

  Apr. 1990 - Present


• 日本高血圧学会

• 超高齢社会における健康寿命延伸に寄与する脂質代謝物の探索的研究

  石田 達郎, 杜 隆嗣, 長尾 学, 篠原 正和

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2024 - 31 Mar. 2027


• 網羅的手法を用いたHDL機能を規定する因子の基礎臨床融合研究

  石田 達郎

  学術研究助成基金助成金／基盤研究(C), Apr. 2018 - Mar. 2021, Principal investigator

  Competitive research funding


• 新規HDL機能評価法を用いた糖代謝異常患者に対する急性冠症候群発症阻止の戦略

  新家 俊郎

  学術研究助成基金助成金／基盤研究(C), Apr. 2017 - Mar. 2020

  Competitive research funding


• Discovery of novel treatment strategy for aortic calcification through CT imaging and metabolome analysis

  Takaya Tomofumi, TOH Ryushi, SHINKE Toshiro, ISHIDA Tatsuro, HIRATA Ken-ichi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2015 - 31 Mar. 2018

  Establishment of comprehensive method for quantification of calcified lesions in aorta: using CT imaging, we developed widely applicable methodology which easily enables us to re-construct three dimensional(3D) image of calcified lesions in aorta. This method allows us to evaluate global and local quantification of calcified lesions, which provides useful information for cardiovascular physicians and cardiovascular surgeons. Serum metabolite profiling which reflects calcified lesion volume in aorta: hydrophilic small molecule metabolites in serum samples from patients who received aortic CT imaging were comprehensively analyzed with gas chromatography mass spectrometry (GC/MS). Through GC/MS based metabolome analysis, we found five metabolites showed statistically significant correlation with calcified lesion volume in aorta. We propose that the mathematical function with these five metabolites could be used as quantitative biomarker which reflects calcified lesion volume in aorta.


• 新規ＨＤＬ機能評価法の実用化と冠動脈疾患リスクの層別化

  石田 達郎

  学術研究助成基金助成金／基盤研究(C), Apr. 2015 - Mar. 2018, Principal investigator

  Competitive research funding


• The role of Trans-fatty acids in deep venous thrombosis

  Hideto Nakajima, TOH RYUJI, ISHIDA TATSUEO

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Kobe University, 01 Apr. 2015 - 31 Mar. 2017

  (1) Five percent of elaidic acid treatment increased the serum concentration of elaidic acid at almost 100-fold. This indicates oral elaidic acid treatment actually increase the circulating elaidic acid level and incorporated into the organs in mice. (2) Afte the 4 weeks of treatment of elaidic acid or oleic acis as a control, we performed IVC ligation to induce deep venous thrombosis. Unfortunately, 6 mice died after the operation. We did not observe statistical significance, but there maybe a tendency that elaidic acid augments the DVT formation. We therefore add 10 more mice to have final conclusion.


• 世界初の急性冠症候群疾患モデルの実現

  小池 智也

  学術研究助成基金助成金／基盤研究(C), Apr. 2014 - Mar. 2017

  Competitive research funding


• 我国におけるトランス脂肪酸の動脈硬化リスクとしての評価

  新家 俊郎

  学術研究助成基金助成金／基盤研究(C), Apr. 2014 - Mar. 2017

  Competitive research funding


• 血管内皮接着因子ＪＣＡＤが心血管病発症に及ぼす影響の解明

  川合 宏哉

  学術研究助成基金助成金／基盤研究(C), Apr. 2013 - Mar. 2016

  Competitive research funding


• 血管内皮リパーゼのＤｙｓｆｕｎｃｔｉｏｎａｌ ＨＤＬと動脈硬化の成因に及ぼす影響

  石田 達郎

  科学研究費補助金／基盤研究(C), Apr. 2012 - Mar. 2015, Principal investigator

  Competitive research funding


• 高比重リポ蛋白による心保護作用についての検討

  川合 宏哉

  科学研究費補助金／基盤研究(C), Apr. 2010 - Mar. 2013

  Competitive research funding


• Effect of altered expression of endothelial lipase on plasma lipids and atherosclerosis in rabbits

  SUN Li, ISHIDA Tatsuro, YASUDA Tomoyuki

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Kobe University, 2011 - 2012

  Endothelial lipase (EL) regulates circulating high-density lipoprotein-cholesterol (HDL-C) levels. There is a discrepancy of EL effect in lipid profiles between mise and humans. Therefore, we investigated the effect of altered EL expression on lipid profile and HDL anti-atherogenic properties in rabbits. Adenovirus encoding human EL (AdhEL) was injected into Japanese white rabbits, which induced hEL overexpression. Consequently, serum HDL-C levels were significantly decreased, while LDL-C levels were not affected. Lipoprotein fractions isolated from humans, rabbits and mice were treated with the EL-rich medium, and measured free fatty acids liberated from the lipoprotein substrates. The hEL hydrolyzed HDL from all three species, while it hydrolyzed mouse LDL much greater than rabbit- and human-LDL. Serum paraoxonase activity, a major component of HDL anti-oxidant properties, significantly reducedin EL-overexpressing rabbits, whereas serum cholesterol efflux capacity did not change despite of the reduced HDL levels. In conclusion, Human EL reduced HDL-C and HDL anti-oxidative property in rabbits. Considering that lipid profile of rabbits resembles that of humans, alteration of EL expression or activity may improve HDLlevels and anti-oxidant properties without affecting LDL-C levels in humans.


• Role of endothelial lipase in anti-inflammatory properties of high-density lipoprotein

  HARA Tetsuya, ISHIDA Tatsuro, HIRATA Ken-ichi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Kobe University, 2010 - 2011

  Inhibition of endothelial lipase(EL) increases plasma high-density lipoprotein cholesterol(HDL-C) level. In this study, we assessed the functional quality of HDL isolated from EL-/-and WT mice. Anti-inflammatory functions of HDL, such as PON-1 or PAF-AH activities, inhibition of cytokine-induced VCAM-1 expression, inhibition of LDL oxidation, were similar between WT and EL-/-mice. In contrast, lipopolysaccharideneutralizing capacity of HDL was higher in EL-/-mice than in WT mice. Intravenous injection of HDL isolated from EL-/-mice improved the mortality in LPS-treated mice. Thus, EL inactivation increased plasma HDL particles with preserved anti-inflammatory and anti-atherosclerotic functions.


• 心筋梗塞発症および冠動脈病変不安定化に関わるバイオマーカーの同定

  塩見 雅志

  科学研究費補助金／基盤研究(B), 2011

  Competitive research funding


• 血管内皮リパーゼによる血清ＨＤＬコレステロール値の制御と生活習慣の関連性の検討

  石川 雄一

  科学研究費補助金／基盤研究(C), 2010

  Competitive research funding


• To discover a novel therapy for preventing atherosclerosis by modulating the interaction between endothelial cell s- monocytes

  YASUDA Tomoyuki, ISHIDA Tatsuro

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Kobe University, 2008 - 2009

  Our aim is to analyze the effect of ESAM on the progression of atherosclerosis. We generated ESAM / apoE double knockout mice and analyzed atherosclerosis lesion size. We also generated ESAM expression reduced endothelial cell by SiRNA method. We found that ESAM inhibition reduced the invasion of monocytes through endothelial cells and ESAM deficiency reduced atherosclerosis in apoE knockout mice. ESAM inhibition might be a novel therapy for preventing atherosclerosis.


• 血清中血管内皮リパーゼ酵素活性の測定法確立と血清ＨＤＬ値の関連の検討

  石田 達郎

  科学研究費補助金／基盤研究(C), 2009, Principal investigator

  Competitive research funding


• 腫瘍血管新生を標的とした新規の抗腫瘍療法の確立

  石田 達郎

  科学研究費補助金／基盤研究(C), 2007, Principal investigator

  Competitive research funding


• 血管内皮リパーゼを標的としたメタボリックシンドロームの病態解明と新規治療法の開発

  平田 健一

  科学研究費補助金／基盤研究(C), 2007

  Competitive research funding


• 糖尿病の脂質代謝異常および動脈硬化の成因にはたす血管内皮リパーゼの役割の解明

  平田 健一

  科学研究費補助金／基盤研究(C), 2005

  Competitive research funding


• 血管内皮特異的接着分子を標的とした糖尿病性血管障害の病態解明と治療法の開発

  石田 達郎

  科学研究費補助金／基盤研究(C), 2005, Principal investigator

  Competitive research funding