Research activity information

• Ifenprodil inhibits nicotine-induced addiction-like behaviors in mice.

  Soichiro Ide, Naotaka Izuo, Yuiko Ikekubo, George R Uhl, Ichiro Sora, Atsumi Nitta, Kazutaka Ikeda

  Nicotine addiction remains a global public health problem, with high relapse rates and limited long-term success from current treatments. This highlights the need for new therapeutic strategies that target novel mechanisms of nicotine addiction. Ifenprodil, a GluN2B-containing N-methyl-d-aspartate receptor antagonist and G protein-activated inwardly rectifying potassium inhibitor, among other actions, potentially offers a new approach. The present study investigated the efficacy of ifenprodil in reducing nicotine-induced addiction-like behaviors. We evaluated effects of systemic ifenprodil administration on nicotine-induced behaviors in mice using two experimental paradigms: a lateral hypothalamus intracranial self-stimulation (lhICSS) test using a rate-frequency procedure and a two-bottle choice preference test. Dopamine transporter (DAT) knockout (KO) and wild-type mice were used to investigate nicotine's effects on reward-related behavior. Nicotine and ifenprodil were delivered via intraperitoneal injection. In wild-type mice, acute nicotine (0.1-1.0 mg/kg) had no significant effect on lhICSS rates across stimulation frequencies, although a low dose (0.1 mg/kg) produced a modest increase. The 0.1 mg/kg dose of nicotine but not higher doses (0.3 or 1.0 mg/kg) significantly enhanced lhICSS rates in DAT-KO mice. Pretreatment with ifenprodil (1-10 mg/kg) dose-dependently reduced the nicotine-induced enhancement of reward in DAT-KO mice. In wild-type males, ifenprodil acutely decreased nicotine preference in the two-bottle choice test following chronic nicotine exposure. These findings indicate that ifenprodil suppresses nicotine-related behaviors primarily in mice on a hyperdopaminergic (DAT-KO) background. Although further validation in wild-type models is warranted to clarify the translational generalizability of these findings, ifenprodil may be a novel approach for the treatment of nicotine addiction.

  Jan. 2026, Life sciences, 384, 124116 - 124116, English, International magazine

  Scientific journal


• μオピオイド受容体遺伝子一塩基多型による喘息免疫応答亢進機序の解析

  宮坂 智充, 川上 佳織, 曽良 一郎, 川上 和義, 有川 智博, 豊島 かおる, 宍戸 史, 佐々木 雅史, 高柳 元明, 大野 勲, 中村 豊

  (一社)日本呼吸器学会, Mar. 2024, 日本呼吸器学会誌, 13(増刊) (増刊), 301 - 301, Japanese


• Effectiveness of the Step-by-Step Interpersonal Adaptation Program for Patients with Severe and Chronic Schizophrenia Who Experience Extreme Difficulty in Social Participation (SIAP-SCS): A Retrospective Study

  Takeshi Kojina, Kayano Yotsumoto, Yuko Nishimura, Tomoe Ebisu, Tadasu Horai, Shinsuke Aoyama, Ichiro Sora, Takeshi Hashimoto

  Informa UK Limited, Feb. 2024, Occupational Therapy in Mental Health, 1 - 17

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization.

  Yuki Moriya, Yoshiyuki Kasahara, Kana Ishihara, Frank Scott Hall, Yoko Hagino, René Hen, Kazutaka Ikeda, George R Uhl, Ichiro Sora

  The psychostimulant drug methamphetamine (METH) causes euphoria in humans and locomotor hyperactivity in rodents by acting on the mesolimbic dopamine (DA) pathway and has severe abuse and addiction liability. Behavioral sensitization, an increased behavioral response to a drug with repeated administration, can persist for many months after the last administration. Research has shown that the serotonin 1B (5-HT1B) receptor plays a critical role in the development and maintenance of drug addiction, as well as other addictive behaviors. This study examined the role of 5-HT1B receptors in METH-induced locomotor sensitization using 5-HT1B knockout (KO) mice. To clarify the action of METH in 5-HT1B KO mice the effects of METH on extracellular levels of DA (DAec) and 5-HT (5-HTec) in the caudate putamen (CPu) and the nucleus accumbens (NAc) were examined. Locomotor sensitization and extracellular monoamine levels were determined in wild-type mice (5-HT1B +/+), heterozygous 5-HT1B receptor KO (5-HT1B +/-) mice and homozygous 5-HT1B receptor KO mice (5-HT1B -/-). Behavioral sensitization to METH was enhanced in 5-HT1B -/- mice compared to 5-HT1B +/+ mice but was attenuated in 5-HT1B +/- mice compared to 5-HT1B +/+ and 5-HT1B -/- mice. In vivo, microdialysis demonstrated that acute administration of METH increases DAec levels in the CPu and NAc of 5-HT1B KO mice compared to saline groups. In 5-HT1B +/- mice, METH increased 5-HTec levels in the CPu, and DAec levels in the NAc were higher than in others.5-HT1B receptors play an important role in regulating METH-induced behavioral sensitization.

  Oct. 2023, Behavioural pharmacology, 34(7) (7), 393 - 403, English, International magazine

  Scientific journal


• μオピオイド受容体欠損マウスにおけるδオピオイド受容体作動薬の相加効果による絶望感軽減の雌雄差

  森屋 由紀, 笠原 好之, 嶋田 政史, 榊原 泰史, 藤井 秀明, 長瀬 博, 井手 聡一郎, 池田 和隆, Hall Scott, Uhl George, 曽良 一郎

  (一社)日本神経精神薬理学会, Sep. 2023, 日本神経精神薬理学会年会プログラム・抄録集, 53回, 173 - 173, English


• 動物モデル1(難治性喘息) 気管支喘息における樹状細胞機能の亢進に関するμオピオイド受容体遺伝子一塩基多型

  宮坂 智充, 川上 佳織, 曽良 一郎, 川上 和義, 有川 智博, 豊島 かおる, 宍戸 史, 佐々木 雅史, 高柳 元明, 大野 勲, 中村 豊

  (一社)日本アレルギー学会, Aug. 2023, アレルギー, 72(6-7) (6-7), 892 - 892, Japanese


• 動物モデル1(難治性喘息) 気管支喘息における樹状細胞機能の亢進に関するμオピオイド受容体遺伝子一塩基多型

  宮坂 智充, 川上 佳織, 曽良 一郎, 川上 和義, 有川 智博, 豊島 かおる, 宍戸 史, 佐々木 雅史, 高柳 元明, 大野 勲, 中村 豊

  (一社)日本アレルギー学会, Aug. 2023, アレルギー, 72(6-7) (6-7), 892 - 892, Japanese


• Telencephalon Organoids Derived from an Individual with ADHD Show Altered Neurodevelopment of Early Cortical Layer Structure.

  Danmeng Zhang, Noriomi Eguchi, Satoshi Okazaki, Ichiro Sora, Akitoyo Hishimoto

  Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that occurs in early childhood and can persist to adulthood. It can affect many aspects of a patient's daily life, so it is necessary to explore the mechanism and pathological alterations. For this purpose, we applied induced pluripotent stem cell (iPSC)-derived telencephalon organoids to recapitulate the alterations occurring in the early cerebral cortex of ADHD patients. We found that telencephalon organoids of ADHD showed less growth of layer structures than control-derived organoids. On day 35 of differentiation, the thinner cortex layer structures of ADHD-derived organoids contained more neurons than those of control-derived organoids. Furthermore, ADHD-derived organoids showed a decrease in cell proliferation during development from day 35 to 56. On day 56 of differentiation, there was a significant difference in the proportion of symmetric and asymmetric cell division between the ADHD and control groups. In addition, we observed increased cell apoptosis in ADHD during early development. These results show alterations in the characteristics of neural stem cells and the formation of layer structures, which might indicate key roles in the pathogenesis of ADHD. Our organoids exhibit the cortical developmental alterations observed in neuroimaging studies, providing an experimental foundation for understanding the pathological mechanisms of ADHD.

  Mar. 2023, Stem cell reviews and reports, 19(5) (5), 1482 - 1491, English, International magazine

  Scientific journal


• Role for μ-opioid receptor in antidepressant effects of δ-opioid receptor agonist KNT-127

  Yuki Moriya, Yoshiyuki Kasahara, Masafumi Shimada, Yasufumi Sakakibara, Hideaki Fujii, Hiroshi Nagase, Soichiro Ide, Kazutaka Ikeda, F. Scott Hall, George R. Uhl, Ichiro Sora

  Mar. 2023, Journal of Pharmacological Sciences, 151(3) (3), 135 - 141, English, Domestic magazine

  Scientific journal


• Preventive effects of preoperative ramelteon on postoperative delirium in Asian elderly population: A randomized, double-blind, placebo-controlled trial, and a systematic review and meta-analysis.

  Takaki Tanifuji, Ikuo Otsuka, Satoshi Okazaki, Tadasu Horai, Ryuhei So, Kyoichi Shiroiwa, Kentaro Mouri, Motofumi Tanaka, Nobuko Ohmoto, Ichiro Sora, Midori Hirai, Takumi Fukumoto, Yonson Ku, Akitoyo Hishimoto

  Oct. 2022, Asian journal of psychiatry, 78, 103282 - 103282, English, International magazine


• 喘息免疫応答の亢進に関与するヒトμオピオイド受容体遺伝子-塩基多型

  宮坂 智充, 川上 佳織, 宮田 敏, 佐藤 美希, 目時 弘仁, 曽良 一郎, 山内 広平, 豊島 かおる, 宍戸 史, 佐々木 雅史, 高柳 元明, 大野 勲, 中村 豊

  日本臨床生理学会, Oct. 2022, 日本臨床生理学会雑誌, 52(4) (4), 58 - 58, Japanese


• Retention and impairment of neurocognitive functions in mild cognitive impairment and Alzheimer's disease with a comprehensive neuropsychological test.

  Lu Yao, Shinsuke Aoyama, Atushi Ouchi, Yasuji Yamamoto, Ichiro Sora

  AIM: MATRICS Consensus Cognitive Battery was developed by the National Institute of Mental Health to establish acceptance criteria for measuring cognitive changes in schizophrenia and can be used to assess cognitive functions in other psychiatric disorders. We used a Japanese version of MATRICS Consensus Cognitive Battery to explore the changes in multiple cognitive functions in patients with mild cognitive impairment and mild Alzheimer's disease. METHODS: We administered the Japanese version of MATRICS Consensus Cognitive Battery to 11 patients with mild cognitive impairment (MCI), 11 patients with Alzheimer's disease, and 27 healthy controls. All Japanese versions of MATRICS Consensus Cognitive Battery domain scores were converted to t-scores using sample means and standard deviations and were compared for significant performance differences among healthy control, MCI, and mild Alzheimer's disease groups. RESULTS: Compared with healthy controls, patients with MCI and mild Alzheimer's disease demonstrated the same degree of impairment to processing speed, verbal learning, and visual learning. Reasoning and problem-solving showed significant impairments only in mild Alzheimer's disease. Verbal and visual abilities in working memory showed different performances in the MCI and mild Alzheimer's disease groups, with the Alzheimer's disease group demonstrating significantly more deficits in these domains. No significant difference was found among the groups in attention/vigilance and social cognition. CONCLUSIONS: The Japanese version of MATRICS Consensus Cognitive Battery can be used to elucidate the characteristics of cognitive dysfunction of normal aging, MCI, and mild dementia in clinical practice.

  Jun. 2022, Neuropsychopharmacology reports, 42(2) (2), 174 - 182, English, International magazine

  Scientific journal


• Improving polygenic prediction in ancestrally diverse populations

  Yunfeng Ruan, Yen-Feng Lin, Yen-Chen Anne Feng, Chia-Yen Chen, Max Lam, Zhenglin Guo, Yong Min Ahn, Kazufumi Akiyama, Makoto Arai, Ji Hyun Baek, Wei J. Chen, Young-Chul Chung, Gang Feng, Kumiko Fujii, Stephen J. Glatt, Kyooseob Ha, Kotaro Hattori, Teruhiko Higuchi, Akitoyo Hishimoto, Kyung Sue Hong, Yasue Horiuchi, Hai-Gwo Hwu, Masashi Ikeda, Sayuri Ishiwata, Masanari Itokawa, Nakao Iwata, Eun-Jeong Joo, Rene S. Kahn, Sung-Wan Kim, Se Joo Kim, Se Hyun Kim, Makoto Kinoshita, Hiroshi Kunugi, Agung Kusumawardhani, Jimmy Lee, Byung Dae Lee, Heon-Jeong Lee, Jianjun Liu, Ruize Liu, Xiancang Ma, Woojae Myung, Shusuke Numata, Tetsuro Ohmori, Ikuo Otsuka, Yuji Ozeki, Sibylle G. Schwab, Wenzhao Shi, Kazutaka Shimoda, Kang Sim, Ichiro Sora, Jinsong Tang, Tomoko Toyota, Ming Tsuang, Dieter B. Wildenauer, Hong-Hee Won, Takeo Yoshikawa, Alice Zheng, Feng Zhu, Lin He, Akira Sawa, Alicia R. Martin, Shengying Qin, Hailiang Huang, Tian Ge

  Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As existing genome-wide association studies (GWAS) have been conducted predominantly in individuals of European descent, the limited transferability of PRS reduces their clinical value in non-European populations, and may exacerbate healthcare disparities. Recent efforts to level ancestry imbalance in genomic research have expanded the scale of non-European GWAS, although most remain underpowered. Here, we present a new PRS construction method, PRS-CSx, which improves cross-population polygenic prediction by integrating GWAS summary statistics from multiple populations. PRS-CSx couples genetic effects across populations via a shared continuous shrinkage (CS) prior, enabling more accurate effect size estimation by sharing information between summary statistics and leveraging linkage disequilibrium diversity across discovery samples, while inheriting computational efficiency and robustness from PRS-CS. We show that PRS-CSx outperforms alternative methods across traits with a wide range of genetic architectures, cross-population genetic overlaps and discovery GWAS sample sizes in simulations, and improves the prediction of quantitative traits and schizophrenia risk in non-European populations.

  Springer Science and Business Media LLC, May 2022, Nature Genetics, 54(5) (5), 573 - 580, English, International magazine

  [Refereed]

  Scientific journal


• Psychological symptoms and related risk factors among healthcare workers and medical students during the early phase of the COVID‐19 pandemic in Japan

  Takaki Tanifuji, Shinsuke Aoyama, Yutaka Shinko, Kentaro Mouri, Saehyeon Kim, Seimi Satomi‐Kobayashi, Masakazu Shinohara, Seiji Kawano, Ichiro Sora

  AIM: The aim of this study was to investigate the mental health status of healthcare workers and medical students during the early phase of the COVID-19 pandemic. METHODS: An online questionnaire was administered to 637 students and 3189 healthcare workers from May to July, 2020. The patient healthcare questionnaire-9 (PHQ-9) and state anxiety (A-State) of the state-trait anxiety inventory-form (STAI) were used to assess depression and anxiety symptoms, respectively. Individuals were categorized into severe (15 or higher) depression and severe (50-51 or higher) anxiety groups. RESULTS: Healthcare workers and those taking care of COVID-19 patients had a higher risk of severe depression (PHQ-9 scores >15) than other comparison groups. Students and men also had a higher risk of severe anxiety (STAI > 50-51). Multivariable logistic regression analysis showed that healthcare workers had a fivefold higher risk of developing severe depression symptoms (adjusted odds ratio [OR] = 4.99, confidence interval [CI] 2.24-5.97, P-value < 0.001) and those taking care of COVID-19 patients had 2.8-fold higher risk of developing severe depression symptoms (OR 2.75, CI 1.36-5.53, P-value = 0.005). CONCLUSION: Both medical students and healthcare workers have been experiencing depression and anxiety symptoms during the first wave of the pandemic. Our findings showed a high rate of severe anxiety symptoms in medical students and a high rate of severe depression symptoms in healthcare workers. Those who treated COVID-19 patients were at greater risk of developing major depressive disorder than those who treated non-COVID-19 patients.

  Wiley, Mar. 2022, Psychiatry and Clinical Neurosciences Reports, 1(1) (1), e5, English, International magazine

  Scientific journal


• Searching for biomarkers in schizophrenia and psychosis: Case-control study using capillary electrophoresis and liquid chromatography time-of-flight mass spectrometry and systematic review for biofluid metabolites.

  Saehyeon Kim, Satoshi Okazaki, Ikuo Otsuka, Yutaka Shinko, Tadasu Horai, Naofumi Shimmyo, Takashi Hirata, Naruhisa Yamaki, Takaki Tanifuji, Shuken Boku, Ichiro Sora, Akitoyo Hishimoto

  Metabolomics has been attracting attention in recent years as an objective method for diagnosing schizophrenia. In this study, we analyzed 378 metabolites in the serum of schizophrenia patients using capillary electrophoresis- and liquid chromatography-time-of-flight mass spectrometry. Using multivariate analysis with the orthogonal partial least squares method, we observed significantly higher levels of alanine, glutamate, lactic acid, ornithine, and serine and significantly lower levels of urea, in patients with chronic schizophrenia compared to healthy controls. Additionally, levels of fatty acids (15:0), (17:0), and (19:1), cis-11-eicosenoic acid, and thyroxine were significantly higher in patients with acute psychosis than in those in remission. Moreover, we conducted a systematic review of comprehensive metabolomics studies on schizophrenia over the last 20 years and observed consistent trends of increase in some metabolites such as glutamate and glucose, and decrease in citrate in schizophrenia patients across several studies. Hence, we provide substantial evidence for metabolic biomarkers in schizophrenia patients through our metabolomics study.

  Mar. 2022, Neuropsychopharmacology reports, 42(1) (1), 42 - 51, English, International magazine

  Scientific journal


• The A118G single-nucleotide polymorphism in OPRM1 is a risk factor for asthma severity.

  Kaori Kawakami, Tomomitsu Miyasaka, Yutaka Nakamura, Hirohito Metoki, Satoshi Miyata, Miki Sato, Ichiro Sora, Kohei Yamauchi, Kazuyoshi Kawakami, Julie A Blendy, Tasuku Kawano, Hiroaki Shimokawa, Motoaki Takayanagi, Isao Ohno, Tomoko Takahashi

  BACKGROUND: Although population studies have implicated emotional burden in asthma severity, the underlying genetic risk factors are not completely understood. We aimed to evaluate the genetic influence of a functional single-nucleotide polymorphism (SNP) in the stress-related μ-opioid receptor gene (OPRM1; A118G SNP, rs1799971) on asthma severity. METHODS: We initially assessed disease severity in asthmatic outpatients carrying A118G. Using an ovalbumin-induced experimental asthma rodent model harboring the functionally equivalent SNP, we investigated the mechanism by which this SNP influences the allergic immune response. RESULTS: Among 292 outpatients, 168 underwent airway hyperresponsiveness (AHR) to methacholine testing. Compared with patients carrying the AA and AG genotypes, those carrying the GG genotype exhibited enhanced AHR. The stress levels were presumed to be moderate among patients and were comparable among genotypes. Compared with Oprm1 AA mice, GG mice demonstrated aggravated asthma-related features and increased pulmonary interleukin-4+CD4+ effector and effector memory T cells under everyday life stress conditions. Intraperitoneal naloxone methiodide injection reduced effector CD4+ T cell elevation associated with increased eosinophil numbers in bronchoalveolar lavage fluid of GG mice to the levels in AA mice, suggesting that elevated Th2 cell generation in the bronchial lymph node (BLN) of GG mice induces enhanced eosinophilic inflammation. CONCLUSIONS: Without forced stress exposure, patients with asthma carrying the OPRM1 GG genotype exhibit enhanced AHR, attributable to enhanced Th2 cell differentiation in the regional lymph node. Further research is necessary to elucidate the role of the OPRM1 A118G genotype in the Th2 cell differentiation pathway in the BLN.

  Jan. 2022, Allergology international : official journal of the Japanese Society of Allergology, 71(1) (1), 55 - 65, English, International magazine

  Scientific journal


• COVID-19パンデミックよる医療従事者および大学生の心理的影響とリスク因子

  谷藤 貴紀, 青山 慎介, 新光 穣, 金 世賢, 小林 成美, 篠原 正和, 河野 誠司, 曽良 一郎

  (公社)日本精神神経学会, Sep. 2021, 精神神経学雑誌, (2021特別号) (2021特別号), S609 - S609, Japanese


• 精神病性障害に対するブレクスピプラゾールの使用経験

  蓬莱 政, 青山 慎介, 木村 敦, 新名 尚史, 平田 尚士, 岡崎 賢志, 江口 典臣, 山木 愛久, 新光 穣, 曽良 一郎

  (公社)日本精神神経学会, Sep. 2021, 精神神経学雑誌, (2021特別号) (2021特別号), S572 - S572, Japanese


• 喘息・食物アレルギー 気管支リンパ節でのTh2細胞の分化に関与するヒトμオピオイド受容体遺伝子一塩基多型

  宮坂 智充, 川上 佳織, 中村 豊, 宮田 敏, 佐藤 美希, 目時 弘仁, 曽良 一郎, 山内 広平, 河野 資, 下川 宏明, 高柳 元明, 高橋 知子, 大野 勲

  (一社)日本アレルギー学会, Aug. 2021, アレルギー, 70(6-7) (6-7), 802 - 802, Japanese


• 気管支喘息におけるTh2型免疫応答の亢進に関与するμオピオイド受容体遺伝子一塩基多型

  宮坂 智充, 川上 佳織, 中村 豊, 宮田 敏, 目時 弘仁, 曽良 一郎, 山内 広平, 河野 資, 下川 宏明, 高柳 元明, 高橋 知子, 大野 勲

  (一社)日本呼吸器学会, Apr. 2021, 日本呼吸器学会誌, 10(増刊) (増刊), 169 - 169, Japanese


• 気管支喘息におけるTh2型免疫応答の亢進に関与するμオピオイド受容体遺伝子一塩基多型

  宮坂 智充, 川上 佳織, 中村 豊, 宮田 敏, 目時 弘仁, 曽良 一郎, 山内 広平, 河野 資, 下川 宏明, 高柳 元明, 高橋 知子, 大野 勲

  (一社)日本呼吸器学会, Apr. 2021, 日本呼吸器学会誌, 10(増刊) (増刊), 169 - 169, Japanese


• Dual actions of 5-MeO-DIPT at the serotonin transporter and serotonin 5-HT1A receptor in the mouse striatum and prefrontal cortex.

  Yoko Hagino, Frank Scott Hall, George R Uhl, Ichiro Sora, Kazutaka Ikeda

  AIMS: 5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a synthetic orally active hallucinogenic tryptamine analogue. The present study examined whether the effects of 5-MeO-DIPT involve the serotonin transporter (SERT) and serotonin 5-hydroxytryptamine-1A (5-HT1A ) receptor in the striatum and prefrontal cortex (PFC). METHODS: We investigated the effects of 5-MeO-DIPT on extracellular 5-HT (5-HTex ) and dopamine (DAex ) levels in the striatum and PFC in wildtype and SERT knockout (KO) mice using in vivo microdialysis, and for comparison the effects of the 5-HT1A receptor antagonist WAY100635 and the 5-HT1A receptor agonist 8-OH-DPAT on 5-HTex . RESULTS: 5-MeO-DIPT decreased 5-HTex levels in the striatum, but not PFC. In SERT-KO mice, 5-MeO-DIPT did not affect 5-HTex levels in the striatum or PFC. In the presence of WAY100635, 5-MeO-DIPT substantially increased 5-HTex levels, suggesting that 5-MeO-DIPT acts on SERT and these effects are masked by its 5-HT1A actions in the absence of WAY100635. 8-OH-DPAT decreased 5-HTex levels in the striatum and PFC in wildtype mice. WAY100635 antagonized the 8-OH-DPAT-induced decrease in 5-HTex levels. In SERT-KO mice, 8-OH-DPAT did not decrease 5-HTex levels in the striatum and PFC. 5-MeO-DIPT dose-dependently increased DAex levels in the PFC, but not striatum, in wildtype and SERT-KO mice. The increase in DAex levels that was induced by 5-MeO-DIPT was not antagonized by WAY100635. CONCLUSION: 5-MeO-DIPT influences both 5-HTex and DAex levels in the striatum and PFC. 5-MeO-DIPT dually acts on SERT and 5-HT1A receptors so that elevations in 5-HTex levels produced by reuptake inhibition are limited by actions of the drug on 5-HT1A receptors.

  Mar. 2021, Neuropsychopharmacology reports, 41(1) (1), 91 - 101, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Epigenetic Clock Analysis in Children With Fetal Alcohol Spectrum Disorder.

  Satoshi Okazaki, Ikuo Otsuka, Yutaka Shinko, Tadasu Horai, Takashi Hirata, Naruhisa Yamaki, Ichiro Sora, Akitoyo Hishimoto

  BACKGROUND: Fetal alcohol spectrum disorder (FASD) is characterized by severe clinical impairment, considerable social burden, and high mortality and morbidity, which are due to various malformations, sepsis, and cancer. As >50% of deaths from FASD occur during the first year of life, we hypothesized that there is the acceleration of biological aging in FASD. Several recent studies have established genome-wide DNA methylation (DNAm) profiles as "epigenetic clocks" that can estimate biological aging, and FASD has been associated with differential DNAm patterns. Therefore, we tested this hypothesis using epigenetic clocks. METHODS: We investigated 5 DNAm-based measures of epigenetic age (HorvathAge, HannumAge, SkinBloodAge, PhenoAge, and GrimAge) and telomere length (DNAmTL) using 4 independent publicly available DNAm datasets; 2 datasets were derived from buccal epithelium, and the other 2 datasets were derived from peripheral blood. RESULTS: Compared with controls, children with FASD exhibited an acceleration of GrimAge in 1 buccal and 2 blood datasets. No significant difference was found in other DNAm ages and DNAmTL. Meta-analyses showed a significant acceleration of GrimAge in the blood samples but not in the buccal samples. CONCLUSIONS: This study provides novel evidence regarding accelerated epigenetic aging in children with FASD.

  Feb. 2021, Alcoholism, clinical and experimental research, 45(2) (2), 329 - 337, English, International magazine

  [Refereed]

  Scientific journal


• Association of Two Variable Number of Tandem Repeats in the Monoamine Oxidase A Gene Promoter with Schizophrenia.

  Takaki Tanifuji, Satoshi Okazaki, Ikuo Otsuka, Tadasu Horai, Yutaka Shinko, Saehyeon Kim, Ichiro Sora, Akitoyo Hishimoto

  Background: Monoamine oxidase-A (MAO-A) decomposes dopamine and serotonin, and decreased MAO-A expression increases monoamine levels and is related to the pathophysiology of schizophrenia. Previous studies have reported that variable number of tandem repeats (VNTR), namely, upstream (u)VNTR, and some single nucleotide polymorphisms (SNPs) in the MAOA gene are associated with schizophrenia. Methods: We investigated the two VNTRs and their related SNPs (rs6323 and rs1137070) in the MAOA gene promoter in 859 patients with schizophrenia and 826 healthy controls. Distal (d)VNTR and uVNTR were genotyped with fluorescence-based fragment polymerase chain reaction assays, and rs6323 and rs1137070 with TaqMan SNP genotyping assays. Results: Neither the genotype nor allelic frequency of the VNTRs or SNPs showed significant differences between the schizophrenia and control groups. On the other hand, analysis of the dVNTR-uVNTR-rs6323-rs1137070 haplotype showed significant association for nine repeats (9R)-3R-T-C in female patients (corrected p = 0.0006, odds ratio [confidence interval] = 2.17 [1.446-3.257]). Conclusion: Our findings provide novel evidence that MAOA gene polymorphisms are associated with an increased risk of developing schizophrenia in females.

  2021, Neuropsychiatric disease and treatment, 17, 3315 - 3323, English, International magazine

  Scientific journal


• Effect of Feru-guard 100M on amyloid-beta deposition in individuals with mild cognitive impairment.

  Kenichi Matsuyama, Yasuji Yamamoto, Ichiro Sora

  AIM: Many researchers argue that Alzheimer's disease is at least partly caused by deposition of amyloid beta (Aβ) in the brain. Ferulic acid (FA) and Angelica archangelica (AA) are candidate agents for reducing Aβ and improving cognitive function. Feru-guard 100M is a supplement containing FA and AA extract. Using this supplement, we planned to assess the effect of FA and AA on Aβ deposition in the human brain. METHODS: This was an open-label, interventional multi-institutional joint study of Kobe University and the Institute of Biomedical Research and Innovation (Kobe, Japan). Seventeen subjects diagnosed with mild cognitive impairment were divided into two groups: the intervention group (n = 10) and the control group (n = 7). The subjects in the intervention group used Feru-guard 100M every day for 48 weeks, whereas the subjects in the control group did not use the supplement. We assessed the differences between the two groups by examining Aβ deposition and brain atrophy at 48 weeks and cognitive function every 24 weeks. We used carbon-11-labelled Pittsburgh compound B (PiB) positron emission tomography to evaluate Aβ deposition. RESULTS: There were no significant differences in Aβ deposition, brain atrophy, and cognitive function between the two groups. Specifically, differences in Aβ deposition change in seven regions of interest examined with PiB positron emission tomography, brain atrophy change in four indicators of voxel-based morphometry, and cognitive impairment measured by five psychological tests were not significantly between the two groups. CONCLUSION: Treatment with Feru-guard 100M, a supplement containing FA and AA extract, for 48 weeks did not reduce cortical PiB retention, which reflects Aβ deposition. It also did not suppress the aggravation of brain atrophy or decline in cognitive function.

  Last, Aug. 2020, Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 20(5) (5), 726 - 736, English, International magazine

  [Refereed]

  Scientific journal


• 気管支喘息の増悪におけるμオピオイド受容体遺伝子一塩基多型の関与

  川上 佳織, 宮坂 智充, 中村 豊, 宮田 敏, 目時 弘仁, 曽良 一郎, 山内 広平, 河野 資, 下川 宏明, 高柳 元明, 高橋 知子, 大野 勲

  (一社)日本呼吸器学会, Aug. 2020, 日本呼吸器学会誌, 9(増刊) (増刊), 324 - 324, Japanese


• ADHD患者由来の大脳皮質オルガノイドで見られた大脳皮質発達の遅延(Telencephalon organoid derived from ADHD patient showed delayed development of cerebral cortex)

  張 丹夢, 江口 典臣, 岡崎 賢志, 曽良 一郎

  日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会, Aug. 2020, 日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集, 50回・42回・4回, 201 - 201, English


• メタボローム解析による統合失調症血液バイオマーカーの探究

  金 世賢, 岡崎 賢志, 大塚 郁夫, 新光 穣, 木村 敦, 蓬莱 政, 新名 尚史, 平田 尚士, 谷藤 貴紀, 山木 愛久, 青山 慎介, 菱本 明豊, 曽良 一郎

  日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会, Aug. 2020, 日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集, 50回・42回・4回, 190 - 190, Japanese


• 自殺完遂者の死後脳におけるケモカインの変化

  新光 穣, 大塚 郁夫, 岡崎 賢志, 蓬莱 政, 朴 秀賢, 高橋 玄倫, 上野 易弘, 曽良 一郎, 菱本 明豊

  日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会, Aug. 2020, 日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集, 50回・42回・4回, 197 - 197, Japanese


• 気管支喘息の増悪におけるμオピオイド受容体遺伝子一塩基多型の関与

  川上 佳織, 宮坂 智充, 中村 豊, 宮田 敏, 目時 弘仁, 曽良 一郎, 山内 広平, 河野 資, 下川 宏明, 高柳 元明, 高橋 知子, 大野 勲

  (一社)日本呼吸器学会, Aug. 2020, 日本呼吸器学会誌, 9(増刊) (増刊), 324 - 324, Japanese


• A reciprocal inhibition model of alternations between under-/overemotional modulatory states in patients with PTSD.

  Toshinori Chiba, Kentaro Ide, Jessica E Taylor, Shuken Boku, Hiroyuki Toda, Tetsufumi Kanazawa, Sumie Kato, Yuka Horiuchi, Akitoyo Hishimoto, Toru Maruyama, Taisuke Yamamoto, Miyako Shirakawa, Ichiro Sora, Mitsuo Kawato, Ai Koizumi

  Patients with posttraumatic stress disorder (PTSD) appear to manifest two opposing tendencies in their attentional biases and symptoms. However, whether common neural mechanisms account for their opposing attentional biases and symptoms remains unknown. We here propose a model in which reciprocal inhibition between the amygdala and ventromedial prefrontal cortex (vmPFC) predicts synchronized alternations between emotional under- and overmodulatory states at the neural, behavioral, and symptom levels within the same patients. This reciprocal inhibition model predicts that when the amygdala is dominant, patients enter an emotional undermodulatory state where they show attentional bias toward threat and manifest re-experiencing symptoms. In contrast, when the vmPFC is dominant, patients are predicted to enter an emotional overmodulatory state where they show attentional bias away from threat and avoidance symptoms. To test the model, we performed a behavioral meta-analysis (total N = 491), analyses of own behavioral study (N = 20), and a neuroimaging meta-analysis (total N = 316). Supporting the model, we found the distributions of behavioral attentional measurements to be bimodal, suggesting alternations between the states within patients. Moreover, attentional bias toward threat was related to re-experiencing symptoms, whereas attentional bias away from threat was related with avoidance symptoms. We also found that the increase and decrease of activity in the left amygdala activity was related with re-experiencing and avoidance symptoms, respectively. Our model may help elucidate the neural mechanisms differentiating nondissociative and dissociative subtypes of PTSD, which usually show differential emotional modulatory levels. It may thus provide a new venue for therapies targeting each subtype.

  Jul. 2020, Molecular psychiatry, 26(9) (9), 5023 - 5039, English, International magazine

  [Refereed]

  Scientific journal


• Decelerated epigenetic aging associated with mood stabilizers in the blood of patients with bipolar disorder.

  Satoshi Okazaki, Shusuke Numata, Ikuo Otsuka, Tadasu Horai, Makoto Kinoshita, Ichiro Sora, Tetsuro Ohmori, Akitoyo Hishimoto

  There is high mortality among patients with bipolar disorder (BD). Studies have reported accelerated biological aging in patients with BD. Recently, Horvath and Hannum et al. independently developed DNA methylation (DNAm) profiles as "epigenetic clocks," which are the most accurate biological age estimate. This led to the development of two accomplished measures of epigenetic age acceleration (EAA) using blood samples, namely, intrinsic and extrinsic EAA (IEAA and EEAA, respectively). IEAA, which is based on Horvath's clock, is independent of blood cell counts and indicates cell-intrinsic aging. On the other hand, EEAA, which is based on Hannum's clock, is associated with age-dependent changes in blood cell counts and indicates immune system aging. Further, Lu et al. developed the "GrimAge" clock, which can strongly predict the mortality risk, and DNAm-based telomere length (DNAmTL). We used a DNAm dataset from whole blood samples obtained from 30 patients with BD and 30 healthy controls. We investigated Horvath EAA, IEAA, Hannum EAA, EEAA, Grim EAA, DNAmTL, and DNAm-based blood cell composition. Compared with controls, there was a decrease in Horvath EAA and IEAA in patients with BD. Further, there was a significant decrease in Horvath EAA and IEAA in patients with BD taking medication combinations of mood stabilizers (including lithium carbonate, sodium valproate, and carbamazepine) than in those taking no medication/monotherapy. This study provides novel evidence indicating decelerated epigenetic aging associated with mood stabilizers in patients with BD.

  May 2020, Translational psychiatry, 10(1) (1), 129 - 129, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• ATP and repetitive electric stimulation increases leukemia inhibitory factor expression in astrocytes: A potential role for astrocytes in the action mechanism of electroconvulsive therapy.

  Soichiro Maruyama, Shuken Boku, Satoshi Okazaki, Hiroki Kikuyama, Yoshito Mizoguchi, Akira Monji, Ikuo Otsuka, Ichiro Sora, Tetsufumi Kanazawa, Akitoyo Hishimoto, Hiroshi Yoneda

  AIM: Electroconvulsive therapy (ECT) is effective for psychiatric disorders. However, its action mechanism remains unclear. We previously reported that transcription factor 7 (TCF7) was increased in patients successfully treated with ECT. TCF7 regulates Wnt pathway, which regulates adult hippocampal neurogenesis. Adult hippocampal neurogenesis is involved in the pathophysiology of psychiatric disorders. Astrocytes play a role in adult hippocampal neurogenesis via neurogenic factors. Of astrocyte-derived neurogenic factors, leukemia inhibitory factor (LIF) and fibroblast growth factor 2 (FGF2) activate Wnt pathway. In addition, adenosine triphosphate (ATP), released from excited neurons, activates astrocytes. Therefore, we hypothesized that ECT might increase LIF and/or FGF2 in astrocytes. To test this, we investigated the effects of ATP and electric stimulation (ES) on LIF and FGF2 expressions in astrocytes. METHODS: Astrocytes were derived from neonatal mouse forebrain and administered ATP and ES. The mRNA expression was estimated with quantitative reverse-transcription polymerase chain reaction. Protein concentration was measured with ELISA. RESULTS: ATP increased LIF, but not FGF2, expression. Multiple ES, but not single, increased LIF expression. Knockdown of P2X2 receptor (P2X2R) attenuated ATP-induced increase of LIF mRNA expression. In contrast, P2X3 and P2X4 receptors intensified it. CONCLUSION: P2X2R may mediate ATP-induced LIF expression in astrocytes and multiple ES directly increases LIF expression in astrocytes. Therefore, both ATP/P2X2R and multiple ES-induced increases of LIF expression in astrocytes might mediate the efficacy of ECT on psychiatric disorders. Elucidating detailed mechanisms of ATP/P2X2R and multiple ES-induced LIF expression is expected to result in the identification of new therapeutic targets for psychiatric disorders.

  May 2020, Psychiatry and clinical neurosciences, 74(5) (5), 311 - 317, English, International magazine

  [Refereed]

  Scientific journal


• Accelerated extrinsic epigenetic aging and increased natural killer cells in blood of suicide completers.

  Satoshi Okazaki, Ikuo Otsuka, Tadasu Horai, Takashi Hirata, Motonori Takahashi, Yasuhiro Ueno, Shuken Boku, Ichiro Sora, Akitoyo Hishimoto

  BACKGROUND: Studies suggest aberrant DNA methylation in victims of suicide. Recently, DNA methylation profiles have been developed for determining "epigenetic age," which is the most accurate estimate of biological age. Subsequently, two refined measures of epigenetic age acceleration have been expanded for blood samples as intrinsic and extrinsic epigenetic age acceleration (IEAA and EEAA, respectively). IEAA involves pure epigenetic aging independent of blood cell composition, whereas EEAA involves immunosenescence in association with blood cell composition. METHODS: We investigated epigenetic age acceleration using two independent DNA methylation datasets: a brain dataset from 16 suicide completers and 15 non-psychiatric controls and a blood dataset compiled using economical DNA pooling technique from 56 suicide completers and 60 living healthy controls. In the blood dataset, we considered IEAA and EEAA, as well as DNA methylation-based blood cell composition. RESULTS: There was no significant difference in universal epigenetic age acceleration between suicide completers and controls in both brain and blood datasets. Blood of suicide completers exhibited an increase in EEAA, but not in IEAA. We additionally found that suicide completers had more natural killer cells but fewer granulocytes compared to controls. CONCLUSION: This study provides novel evidence for accelerated extrinsic epigenetic aging in suicide completers and for the potential application of natural killer cells as a biomarker for suicidal behavior.

  Mar. 2020, Progress in neuro-psychopharmacology & biological psychiatry, 98, 109805 - 109805, English, International magazine

  [Refereed]

  Scientific journal


• オピオイド受容体遺伝子-塩基多型と喘息重症度の解析

  原田 真裕美, 宮坂 智充, 川上 佳織, 中村 豊, 宮田 敏, 佐藤 美希, 目時 弘仁, 曽良 一郎, 山内 広平, 河野 資, 下川 宏明, 高柳 元明, 高橋 知子, 大野 勲

  (公社)日本薬学会, Mar. 2020, 日本薬学会年会要旨集, 140年会, 27I - pm07S, Japanese


• 軽度認知障害・軽度アルツハイマー型認知症における記憶モニタリング

  林 敦子, 古和 久朋, 立花 久嗣, 阪井 一雄, 山本 泰司, 青山 慎介, 曽良 一郎

  (一社)日本高次脳機能障害学会, Mar. 2020, 高次脳機能研究, 40(1) (1), 36 - 36, Japanese


• Chemokine alterations in the postmortem brains of suicide completers.

  Yutaka Shinko, Ikuo Otsuka, Satoshi Okazaki, Tadasu Horai, Shuken Boku, Motonori Takahashi, Yasuhiro Ueno, Ichiro Sora, Akitoyo Hishimoto

  Suicide is a major health problem in the modern world. However, its physiological mechanisms have not been well elucidated yet. Immunological disturbances have been reported in psychiatric disorders such as major depressive disorder (MDD), bipolar disorder (BP), and schizophrenia. Some studies have also suggested an association between immunological alterations especially neuroinflammation, and suicide. Chemokines play important roles in inflammation, and studies investigating chemokines in psychiatric diseases such as schizophrenia, MDD, and BP have reported chemokine dysregulations. However, there have been very few studies on the association between chemokines and suicide. We studied chemokine alterations in the postmortem brains of suicide completers and compared them to those of controls. We obtained brain tissue samples of the dorsolateral prefrontal cortex from 16 suicide completers and 23 controls. We examined the concentrations of chemokines and related substances in the brain tissue from these two groups using the Bio-Plex Pro™ Human Chemokine Panel 40-Plex. We performed multiple regression analysis with covariates. The levels of CCL1, CCL8, CCL13, CCL15, CCL17, CCL19, CCL20, CXCL11, and IL-10 were significantly decreased, whereas the IL-16 levels were significantly increased in the suicide completers after adjustment with the Benjamini-Hochberg method to control for type Ⅰ errors (Q < 0.05). The observed chemokine alterations might suggest the presence of suicide-specific immunological mechanisms.

  Jan. 2020, Journal of psychiatric research, 120, 29 - 33, English, International magazine

  [Refereed]

  Scientific journal


• A Single Medical Marker for Diagnosis of Methamphetamine Addiction - DNA Methylation of SHATI/NAT8L Promoter Sites from Patient Blood.

  Kusui Yuka, Daisuke Nishizawa, Junko Hasegawa, Kyosuke Uno, Hajime Miyanishi, Hiroshi Ujike, Norio Ozaki, Toshiya Inada, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Mitsuhiko Yamada, Naoki Kondo, Moo-Jun Won, Nobuya Naruse, Kumi Uehara-Aoyama, Kazutaka Ikeda, Atsumi Nitta

  BACKGROUND: Methamphetamine (METH) is one of the most widely distributed psychostimulants worldwide. Despite active counter measures taken by different countries, neither overall usage of METH nor the frequency of repeat users has reduced over the past decade. METH induces abuse and dependence as it acts on the central nervous system and temporarily stimulates the brain. The recidivism rate for abuse of stimulants in Japan is very high and therefore prevention of repeated usage is paramount. However, we lack information about the relationship between METH users and genomic changes in humans in Japan, which would provide important information to aid such efforts. OBJECTIVE: Shati/Nat8l is a METH-inducible molecule and its overexpression has protective effects on the brain upon METH usage. Here we investigated the effect of METH usage on DNA methylation rates at the promoter site of SHATI/NAT8L. We used DNA samples from human METH users, who are usually difficult to recruit in Japan. METHODS: We measured DNA methylation at SHATI/NAT8L promoter sites by pyrosequencing method using 193 samples of METH users and 60 samples of healthy subjects. In this method, DNA methylation is measured by utilizing the property that only non-methylated cytosine changes to urasil after bisulfite conversion. RESULTS: We found that the rate of DNA methylation at six CpG islands of SHATI/NAT8L promoter sites is significantly higher in METH users when compared to healthy subjects. CONCLUSION: These results suggest that the DNA methylation rate of SHATI/NAT8L promotor regions offers a new diagnostic method for METH usage.

  2020, Current pharmaceutical design, 26(2) (2), 260 - 264, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population.

  Ikuo Otsuka, Masato Akiyama, Osamu Shirakawa, Satoshi Okazaki, Yukihide Momozawa, Yoichiro Kamatani, Takeshi Izumi, Shusuke Numata, Motonori Takahashi, Shuken Boku, Ichiro Sora, Ken Yamamoto, Yasuhiro Ueno, Tatsushi Toda, Michiaki Kubo, Akitoyo Hishimoto

  Suicide is a significant public health problem worldwide, and several Asian countries including Japan have relatively high suicide rates on a world scale. Twin, family, and adoption studies have suggested high heritability for suicide, but genetics lags behind due to difficulty in obtaining samples from individuals who died by suicide, especially in non-European populations. In this study, we carried out genome-wide association studies combining two independent datasets totaling 746 suicides and 14,049 non-suicide controls in the Japanese population. Although we identified no genome-wide significant single-nucleotide polymorphisms (SNPs), we demonstrated significant SNP-based heritability (35-48%; P < 0.001) for completed suicide by genomic restricted maximum-likelihood analysis and a shared genetic risk between two datasets (Pbest = 2.7 × 10-13) by polygenic risk score analysis. This study is the first genome-wide association study for suicidal behavior in an East Asian population, and our results provided the evidence of polygenic architecture underlying completed suicide.

  Nov. 2019, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 44(12) (12), 2119 - 2124, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Major depressive disorder-associated SIRT1 locus affects the risk for suicide in women after middle age.

  Takashi Hirata, Ikuo Otsuka, Satoshi Okazaki, Kentaro Mouri, Tadasu Horai, Shuken Boku, Motonori Takahashi, Yasuhiro Ueno, Ichiro Sora, Osamu Shirakawa, Akitoyo Hishimoto

  A recent genome-wide association study (GWAS) for major depressive disorder (MDD) in Chinese women identified a single-nucleotide polymorphism (SNP), rs12415800, near the Sirtuin1 (SIRT1) gene as one of the top candidate loci. However, no study has shown a genetic association between SIRT1 and completed suicide, which is one of the most serious outcomes of MDD. In this study, 778 suicide completers and 760 controls in a Japanese population were genotyped for two SNPs in strong linkage disequilibrium (rs12415800 and rs4746720 in 3'UTR). We found significant associations between both SNPs and completed suicide among women aged ≥50 years. Additional analysis using postmortem brain tissues (10 suicide brains and 13 non-suicide brains) revealed the following: while SIRT1 gene expression in the prefrontal cortex did not differ between suicide and non-suicide brains, DNAJC12 gene expression, potentially implicated by the SNPs genotyped here, was significantly decreased in suicide brains (p = 0.003). In conclusion, regarding the genetic association of SIRT1 with MDD that was previously identified in women by the Chinese GWAS, we successfully validated our results using a female suicidal cohort in the same Asian population with the same direction of allelic effect.

  Aug. 2019, Psychiatry research, 278, 141 - 145, English, International magazine

  [Refereed]

  Scientific journal


• 統合失調症におけるマクロファージ遊走阻止因子(MIF)の血清濃度増加と遺伝子多型関連解析

  岡崎 賢志, 大塚 郁夫, 渡部 雄一郎, 朴 秀賢, 新名 尚史, 平田 尚士, 蓬莱 政, 染矢 俊幸, 曽良 一郎, 菱本 明豊

  (公社)日本精神神経学会, Jun. 2019, 精神神経学雑誌, (2019特別号) (2019特別号), S441 - S441, Japanese


• 統合失調症におけるY染色体モザイク欠損の検討

  平田 尚士, 菱本 明豊, 大塚 郁夫, 岡崎 賢志, 朴 秀賢, 木村 敦, 蓬莱 政, 曽良 一郎

  Last, (公社)日本精神神経学会, Jun. 2019, 精神神経学雑誌, (2019特別号) (2019特別号), S473 - S473, Japanese


• 男性アルコール依存症患者の骨密度低下に関する横断的研究

  蓬莱 政, 菱本 明豊, 大塚 郁夫, 新名 尚史, 岡崎 賢志, 毛利 健太朗, 朴 秀賢, 曽良 一郎

  Last, (公社)日本精神神経学会, Jun. 2019, 精神神経学雑誌, (2019特別号) (2019特別号), S749 - S749, Japanese


• 自殺既遂者の血液・脳組織におけるY染色体喪失の解析

  木村 敦, 菱本 明豊, 平田 尚士, 山本 愛久, 蓬莱 政, 新名 尚史, 大塚 郁夫, 岡崎 賢志, 朴 秀賢, 曽良 一郎

  Last, (公社)日本精神神経学会, Jun. 2019, 精神神経学雑誌, (2019特別号) (2019特別号), S759 - S759, Japanese


• Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice.

  Yoshiyuki Kasahara, Yasufumi Sakakibara, Takashi Hiratsuka, Yuki Moriya, Klaus-Peter Lesch, F Scott Hall, George R Uhl, Ichiro Sora

  AIM: Repeated psychostimulant drug treatment, including methamphetamine, in rodents readily produces behavioral sensitization, which reflects altered brain function caused by repeated drug exposure. Dendritic remodeling of medium spiny neurons in the nucleus accumbens is thought to be an essential mechanism underlying behavioral sensitization. We recently showed that chronic methamphetamine treatment did not produce behavioral sensitization in serotonin transporter knockout mice. METHODS: In this study, we report the spine density of medium spiny neurons in the nucleus accumbens after repeated methamphetamine injection to examine morphological alterations in serotonin transporter knockout mice. RESULTS: Golgi-COX staining clearly showed that the spine density of medium spiny neurons in the nucleus accumbens increased following repeated methamphetamine treatment in both wild-type and serotonin transporter knockout mice. CONCLUSIONS: Our results suggested that augmented serotonergic neurotransmission produced by serotonin transporter deletion prevents the development of behavioral sensitization in a manner that is independent of dendritic remodeling in the nucleus accumbens.

  Jun. 2019, Neuropsychopharmacology reports, 39(2) (2), 130 - 133, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Epigenetic clock analysis of blood samples from Japanese schizophrenia patients.

  Satoshi Okazaki, Ikuo Otsuka, Shusuke Numata, Tadasu Horai, Kentaro Mouri, Shuken Boku, Tetsuro Ohmori, Ichiro Sora, Akitoyo Hishimoto

  The accelerated aging hypothesis of schizophrenia (SCZ) has been proposed. DNA methylation profiles were developed for determining "epigenetic age." Here, we assessed intrinsic and extrinsic epigenetic age acceleration (IEAA and EEAA, respectively) in SCZ. We examined two independent cohorts of Japanese ancestry. The first cohort consisted of 80 patients with SCZ under long-term or repeated hospitalization and 40 controls, with the economical DNA pooling technique. The second cohort consisted of 24 medication-free patients with SCZ and 23 controls. Blood of SCZ subjects exhibited decreased EEAA in the first cohort (p = 0.0162), but not in the second cohort. IEAA did not differ in either cohort. We performed replication analyses using publicly available datasets from European ancestry (three blood and one brain datasets). One blood dataset showed increased EEAA in SCZ (p = 0.0228). Overall, our results provide evidence for decreased EEAA in SCZ associated with hospitalization in the Japanese population.

  Feb. 2019, NPJ schizophrenia, 5(1) (1), 4 - 4, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Current Status of Neurofeedback for Post-traumatic Stress Disorder: A Systematic Review and the Possibility of Decoded Neurofeedback.

  Toshinori Chiba, Tetsufumi Kanazawa, Ai Koizumi, Kentarou Ide, Vincent Taschereau-Dumouchel, Shuken Boku, Akitoyo Hishimoto, Miyako Shirakawa, Ichiro Sora, Hakwan Lau, Hiroshi Yoneda, Mitsuo Kawato

  Background: Post-traumatic stress disorder (PTSD) is a neuropsychiatric affective disorder that can develop after traumatic life-events. Exposure-based therapy is currently one of the most effective treatments for PTSD. However, exposure to traumatic stimuli is so aversive that a significant number of patients drop-out of therapy during the course of treatment. Among various attempts to develop novel therapies that bypass such aversiveness, neurofeedback appears promising. With neurofeedback, patients can unconsciously self-regulate brain activity via real-time monitoring and feedback of the EEG or fMRI signals. With conventional neurofeedback methods, however, it is difficult to induce neural representation related to specific trauma because the feedback is based on the neural signals averaged within specific brain areas. To overcome this difficulty, novel neurofeedback approaches such as Decoded Neurofeedback (DecNef) might prove helpful. Instead of the average BOLD signals, DecNef allows patients to implicitly regulate multivariate voxel patterns of the BOLD signals related with feared stimuli. As such, DecNef effects are postulated to derive either from exposure or counter-conditioning, or some combination of both. Although the exact mechanism is not yet fully understood. DecNef has been successfully applied to reduce fear responses induced either by fear-conditioned or phobic stimuli among non-clinical participants. Methods: Follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review was conducted to compare DecNef effect with those of conventional EEG/fMRI-based neurofeedback on PTSD amelioration. To elucidate the possible mechanisms of DecNef on fear reduction, we mathematically modeled the effects of exposure-based and counter conditioning separately and applied it to the data obtained from past DecNef studies. Finally, we conducted DecNef on four PTSD patients. Here, we review recent advances in application of neurofeedback to PTSD treatments, including the DecNef. This review is intended to be informative for neuroscientists in general as well as practitioners planning to use neurofeedback as a therapeutic strategy for PTSD. Results: Our mathematical model suggested that exposure is the key component for DecNef effects in the past studies. Following DecNef a significant reduction of PTSD severity was observed. This effect was comparable to those reported for conventional neurofeedback approach. Conclusions: Although a much larger number of participants will be needed in future, DecNef could be a promising therapy that bypasses the unpleasantness of conscious exposure associated with conventional therapies for fear related disorders, including PTSD.

  2019, Frontiers in human neuroscience, 13, 233 - 233, English, International magazine

  [Refereed]

  Scientific journal


• Mice deficient in protein tyrosine phosphatase receptor type Z (PTPRZ) show reduced responsivity to methamphetamine despite an enhanced response to novelty.

  Akihiro Fujikawa, Yukihiro Noda, Hideko Yamamoto, Naomi Tanga, Gaku Sakaguchi, Satoko Hattori, Wen-Jie Song, Ichiro Sora, Toshitaka Nabeshima, Goro Katsuura, Masaharu Noda

  Methamphetamine (METH), a commonly abused drug, elevates extracellular dopamine (DA) levels by inducing DA efflux through the DA transporter (DAT). Emerging evidence in rodent models suggests that locomotor responses to a novel inescapable open field may predict behavioral responses to abused drugs; METH produces more potent stimulant effects in high responders to novelty than in low responders. We herein found that mice deficient in protein tyrosine phosphatase receptor type Z (Ptprz-KO) exhibited an enhanced behavioral response to novelty; however, METH-induced hyperlocomotion was significantly lower in Ptprz-KO than in wild-type mice when METH was administered at a non-toxic dose of 1 mg per kg body weight (bdw). Single-cell RT-PCR revealed that the majority of midbrain DA neurons expressed PTPRZ. No histological alterations were observed in the mesolimbic or nigrostriatal dopaminergic pathways in Ptprz-KO brains; however, a significant decrease was noted in brain DA turnover, suggesting functional alterations. In vivo microdialysis experiments revealed that METH-evoked DA release in the nucleus accumbens was significantly lower in Ptprz-KO mice than in wild-type mice. Consistent with this result, Ptprz-KO mice showed significantly fewer cell surface DAT as well as weaker DA uptake activity in striatal synaptosomes prepared 1 hr after the administration of METH than wild-type mice, while no significant differences were observed in the two groups treated with saline. These results indicate that the high response phenotype of Ptprz-KO mice to novelty may not be simply attributed to hyper-dopaminergic activity, and that deficits in PTPRZ reduce the effects of METH by reducing DAT activity.

  2019, PloS one, 14(8) (8), e0221205, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Mitochondrial DNA copy number of peripheral blood in bipolar disorder: The present study and a meta-analysis.

  Naruhisa Yamaki, Ikuo Otsuka, Shusuke Numata, Masaya Yanagi, Kentaro Mouri, Satoshi Okazaki, Shuken Boku, Tadasu Horai, Tetsuro Ohmori, Osamu Shirakawa, Ichiro Sora, Akitoyo Hishimoto

  Numerous evidence indicated mitochondrial abnormalities in the pathophysiology of bipolar disorder (BD); however, it remains unclear whether aberrant mitochondrial DNA (mtDNA) copy number (cn) occur in BD due to the conflicting results in previous studies. Here, peripheral blood mtDNAcn in 69 BD patients and 54 controls were analysed via qPCR. BD patients had significantly lower mtDNAcn compared to controls (regardless of their BD type [BD I or II]). Meta-analysis for all previous BD-mtDNAcn studies combining our results with previously published studies failed to identify any significant association. Meanwhile, Asian-specific meta-analysis remarkably revealed lower mtDNAcn in BD patients.

  Nov. 2018, Psychiatry research, 269, 115 - 117, English, International magazine

  [Refereed]

  Scientific journal


• Reward-enhancing effect of methylphenidate is abolished in dopamine transporter knockout mice: A model of attention-deficit/hyperactivity disorder.

  Soichiro Ide, Yuiko Ikekubo, Jennifer Hua, Yukio Takamatsu, George R Uhl, Ichiro Sora, Kazutaka Ikeda

  AIM: Attention-deficit/hyperactivity disorder is a heterogeneous neurobiological disorder that is characterized by inattention, impulsivity, and an increase in motor activity. Although methylphenidate has been used as a medication for decades, unknown is whether methylphenidate treatment can cause drug dependence in patients with attention-deficit/hyperactivity disorder. This study investigated the reward-enhancing effects of methylphenidate using intracranial self-stimulation in an animal model of attention-deficit/hyperactivity disorder, dopamine transporter knockout mice. METHODS: For the intracranial self-stimulation procedures, the mice were trained to nosepoke to receive direct electrical stimulation via an electrode that was implanted in the lateral hypothalamus. After the acquisition of nosepoke responding for intracranial self-stimulation, the effects of methylphenidate on intracranial self-stimulation were investigated. RESULTS: In the progressive-ratio procedure, dopamine transporter knockout mice exhibited an increase in intracranial self-stimulation compared with wild-type mice. Treatment with 5 and 10 mg/kg methylphenidate increased intracranial self-stimulation responding in wild-type mice. Methylphenidate at the same doses did not affect intracranial self-stimulation responding in dopamine transporter knockout mice. We then investigated the effects of high-dose methylphenidate (60 mg/kg) in a rate-frequency procedure. High-dose methylphenidate significantly decreased intracranial self-stimulation responding in both wild-type and dopamine transporter knockout mice. CONCLUSIONS: These results suggest that low-dose methylphenidate alters the reward system (ie, increases intracranial self-stimulation responding) in wild-type mice via dopamine transporter inhibition, whereas dopamine transporter knockout mice do not exhibit such alterations. High-dose methylphenidate appears to suppress intracranial self-stimulation responding not through dopamine transporter inhibition but rather through other mechanisms. These results support the possibility that methylphenidate treatment for attention-deficit/hyperactivity disorder does not increase the risk of drug dependence, in attention-deficit/hyperactivity disorder patients with dopamine transporter dysfunction.

  Sep. 2018, Neuropsychopharmacology reports, 38(3) (3), 149 - 153, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Longer telomeres in elderly schizophrenia are associated with long-term hospitalization in the Japanese population.

  Yuan Zhang, Akitoyo Hishimoto, Ikuo Otsuka, Yuichiro Watanabe, Shusuke Numata, Hidenaga Yamamori, Shuken Boku, Tadasu Horai, Toshiyuki Someya, Tetsuro Ohmori, Ryota Hashimoto, Ichiro Sora

  Several previous studies have investigated an association between leukocyte telomere length (LTL) and schizophrenia (SCZ). However, results have been largely inconsistent, partially due to the relatively small sample sizes in each study and heterogeneity caused by various uncontrolled confounders (e.g., duration of illness or hospitalization, lifetime antipsychotic dose, and LTL assay methods). Here, we investigate the association of LTL with SCZ with the quantitative polymerase chain reaction method in independent cohorts consisting of 1241 patients with SCZ and 1042 controls (the largest independent sample in this field). Furthermore, we examined whether duration of hospitalization and lifetime antipsychotic dose had an effect on LTL in SCZ. In all samples, we observed significantly longer LTL in patients with SCZ relative to controls. In subgroup analyses, we observed that longer telomeres in SCZ were only visible in elderly patients and not in patients under 50 years old. Moreover, significantly longer LTL in elderly patients with SCZ was only specific to those with long-term hospitalization, but not outpatients or those with short-term hospitalization. This may be because the former received more appropriate lifestyle management. Meanwhile, lifetime antipsychotic dose had no effect on LTL. Our findings suggest that consideration of the effect of age and duration of hospitalization on LTL may improve our understanding of controversial results obtained in previous studies of telomeres in SCZ.

  Last, Aug. 2018, Journal of psychiatric research, 103, 161 - 166, English, International magazine

  [Refereed]

  Scientific journal


• 初期臨床研修における復職支援「Back-on-trackプログラム」の実践と課題

  木村真希, 坂口一彦, 伊藤智雄, Maniwa Yoshimasa, 河野誠司, 木村敦, Ichiro Sora

  (一社)日本医学教育学会, Jul. 2018, 医学教育, 49(Suppl.) (Suppl.), 237 - 237, Japanese


• 統合失調症症状とパーキンソン症状を合併した22q11.2欠損症候群に対し修正型電気けいれん療法が奏功した1例

  谷藤貴紀, Hishimoto Akitoyo, 木村敦, 青山慎介, 佐竹渉, Ichiro Sora

  (公社)日本精神神経学会, Jun. 2018, 精神神経学雑誌, (2018特別号) (2018特別号), S340 - S340, Japanese


• Increased serum levels and promoter polymorphisms of macrophage migration inhibitory factor in schizophrenia.

  Satoshi Okazaki, Akitoyo Hishimoto, Ikuo Otsuka, Yuichiro Watanabe, Shusuke Numata, Shuken Boku, Naofumi Shimmyo, Makoto Kinoshita, Emiko Inoue, Tetsuro Ohmori, Toshiyuki Someya, Ichiro Sora

  BACKGROUND: Numerous studies have suggested that an immune system imbalance plays an important role in schizophrenia. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine. It plays multiple roles in various biological processes, including inflammation and neurogenesis. Furthermore, several exhaustive serum proteomic profiling studies have identified MIF as a potential biomarker of schizophrenia. Here, we investigate MIF protein levels in serum and postmortem prefrontal cortex in patients with schizophrenia and controls. Moreover, we investigate the association of two functional polymorphisms in the MIF gene promoter region (MIF-794CATT5-8 microsatellite and MIF-173G/C single-nucleotide polymorphism [SNP]) with schizophrenia. METHODS: We measured serum MIF levels with an enzyme-linked immunosorbent assay (ELISA) (51 patients vs. 86 controls) and postmortem brain MIF levels with a western blotting assay (18 patients vs. 22 controls). Subsequently, we genotyped the MIF-794CATT5-8 microsatellite with a fluorescence-based fragment assay and the MIF-173G/C SNP with a TaqMan SNP genotyping assay (1483 patients vs. 1454 controls). RESULTS: Serum MIF levels were significantly higher in patients with schizophrenia than in controls (p=0.00118), and were positively correlated with antipsychotic dose (Spearman's r=0.222, p=0.0402). In addition, an earlier age of onset was observed in patients with a high serum MIF level (≥40ng/mL) than those with a low serum MIF level (<40ng/mL) (p=0.0392). However, postmortem brain MIF levels did not differ between patients with schizophrenia and controls. The association study revealed that the CATT6-G haplotype was nominally significantly associated with schizophrenia (p=0.0338), and that the CATT6 allele and CATT6-G haplotype were significantly associated with female adolescent-onset schizophrenia (AsOS) (corrected p=0.0222 and p=0.0147, respectively). CONCLUSIONS: These results suggest that serum MIF level is a potential pharmacodynamic and/or monitoring marker of schizophrenia, and is related to a novel antipsychotic effect beyond dopamine antagonism. Furthermore, the MIF gene polymorphisms are associated with the risk for schizophrenia especially in adolescent females, and are potential stratification markers of schizophrenia. Further studies of MIF are warranted to elucidate the pathophysiology of schizophrenia and the effects of antipsychotics.

  Last, Apr. 2018, Progress in neuro-psychopharmacology & biological psychiatry, 83, 33 - 41, English, International magazine

  [Refereed]

  Scientific journal


• Self-organizing cortex generated from human iPSCs with combination of FGF2 and ambient oxygen.

  Noriomi Eguchi, Ichiro Sora, Keiko Muguruma

  Elsevier B.V., Apr. 2018, Biochemical and biophysical research communications, 498(4) (4), 729 - 735, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Loss of chromosome Y in blood, but not in brain, of suicide completers.

  Atsushi Kimura, Akitoyo Hishimoto, Ikuo Otsuka, Satoshi Okazaki, Shuken Boku, Tadasu Horai, Takeshi Izumi, Motonori Takahashi, Yasuhiro Ueno, Osamu Shirakawa, Ichiro Sora

  Men have a higher rate of completed suicide than women, which suggests that sex chromosome abnormalities may be related to the pathophysiology of suicide. Recent studies have found an aberrant loss of chromosome Y (LOY) in various diseases; however, no study has investigated whether there is an association between LOY and suicide. The purpose of this study was to determine whether LOY occurs in men who completed suicide. Our study consisted of 286 male Japanese subjects comprised of 140 suicide completers without severe physical illness (130 post-mortem samples of peripheral blood and 10 brains) and 146 age-matched control subjects (130 peripheral blood samples from healthy individuals and 16 post-mortem brains). LOY was measured as the chromosome Y/chromosome X ratio of the fluorescent signal of co-amplified short sequences from the Y-X homologous amelogenin genes (AMELY and AMELX). Regression analyses showed that LOY in the blood of suicide completers was significantly more frequent than that found in controls (odds ratio = 3.50, 95% confidence interval = 1.21-10.10), but not in the dorsolateral prefrontal cortex (DLPFC) region of brain. Normal age-dependent LOY in blood was found in healthy controls (r = -0.353, p < 0.001), which was not seen in suicide completers (r = -0.119, p = 0.177). DLPFC tissue had age-dependent LOY (B = -0.002, p = 0.015), which was independent of phenotype. To our knowledge, this is the first study demonstrating that LOY in blood is associated with suicide completion. In addition, our findings are the first to also indicate that age-dependent LOY may occur not only in blood, but also in specific brain regions.

  Last, 2018, PloS one, 13(1) (1), e0190667, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A cross-sectional study exploring useful indicators for low bone mineral density in male alcoholic patients.

  Tadasu Horai, Akitoyo Hishimoto, Ikuo Otsuka, Tatsuhiro So, Kentaro Mouri, Naofumi Shimmyo, Shuken Boku, Noriaki Okishio, Ichiro Sora

  Background: Alcohol dependence induces low bone mineral density (BMD), predicting osteoporosis, while low and moderate alcohol consumption may even increase BMD. In recent years, undercarboxylated osteocalcin (ucOC) and tartrate-resistant acid phosphatase-5b (TRACP-5b), bone turnover markers, have gained special interest as useful indicators of low BMD. However, it remains unclear whether other alcohol-related variables (eg, duration of abstinence and continuous drinking) are linked to aberrant BMD. In addition, no previous study has investigated whether ucOC or TRACP-5b is clinically useful to predict low BMD not only in the general population, but also in alcohol-dependent subjects. Patients and methods: We recruited 275 male alcohol-dependent subjects and collected information about their drinking habits, comorbid diseases, smoking history and walking exercise behavior. BMD in each subject was determined by ultrasonography. Serum liver enzymes (AST, ALT, ALP, ChE, γ-GTP and LDH), ucOC and TRACP-5b were measured in all subjects. T-scores were calculated according to BMD for all subjects. Results: The mean T-scores of our subjects were negatively shifted compared to the general population (-0.75±1.36 SD). We divided our subjects into a normal BMD group (n=137) and a low BMD group (n=138) according to their T-scores (T-score ≥-1 SD, normal BMD; T-score <-1 SD, low BMD). Multivariate logistic regression analysis showed that body mass index (BMI) was negatively associated with low BMD (95% CI: 0.75-0.90). By contrast, long abstinence period (95% CI: 1.40-4.21), smoking (95% CI: 1.30-5.56), hypertension (95% CI: 1.04-3.76), lactate dehydrogenase (LDH) (95% CI: 1.00-1.01) and ucOC (95% CI: 1.04-1.22) were positively associated with low BMD. Conclusion: In alcohol-dependent males, smoking habits and higher ucOC are associated with low BMD. Our study suggests that smoking cessation may prevent lower BMD, and ucOC may predict lower BMD in alcohol-dependent individuals.

  Last, 2018, Neuropsychiatric disease and treatment, 14, 663 - 669, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Neurocognitive Impairments Are More Severe in the Binge-Eating/Purging Anorexia Nervosa Subtype Than in the Restricting Subtype.

  Hiroko Tamiya, Atushi Ouchi, Runshu Chen, Shiho Miyazawa, Yoritaka Akimoto, Yasuhiro Kaneda, Ichiro Sora

  Frontiers Media S.A., 2018, Frontiers in psychiatry, 9, 138 - 138, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Investigation of chromosome Y loss in men with schizophrenia.

  Takashi Hirata, Akitoyo Hishimoto, Ikuo Otsuka, Satoshi Okazaki, Shuken Boku, Atsushi Kimura, Tadasu Horai, Ichiro Sora

  Background: Life expectancy is 10-20 years lower in patients with schizophrenia than in the general population. In addition, men with schizophrenia have an earlier age at onset, more pronounced deficit symptoms, poorer course, and poorer response to antipsychotic medications than women. Recent studies have indicated that loss of chromosome Y (LOY) in peripheral blood is associated with an increased risk of all-cause mortality. In order to elucidate the pathophysiology of male-specific features, we investigated the association between LOY and schizophrenia. Materials and methods: The present study included 360 Japanese men (146 patients with schizophrenia vs 214 controls). The relative amount of Y chromosome was defined as the ratio of chromosome Y to chromosome X (Y/X ratio) based on the fluorescent signal of co-amplified short sequences from the Y-X homologous amelogenin genes (AMELY and AMELX). Results: There was no significant difference in the frequency of LOY between the schizophrenia and control groups. However, longer duration of illness was associated with LOY after controlling for age and smoking status in the schizophrenia group (P=0.007, OR =1.11 [95% CI =1.03-1.19]). Conclusion: According to our results, schizophrenia may not have a remarkable effect on blood LOY; however, LOY may be associated with disease course in patients with schizophrenia.

  Last, 2018, Neuropsychiatric disease and treatment, 14, 2115 - 2122, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Larger Numbers of Glial and Neuronal Cells in the Periaqueductal Gray Matter of μ-Opioid Receptor Knockout Mice.

  Kazumasu Sasaki, Frank Scott Hall, George R Uhl, Ichiro Sora

  Background: μ-opioid receptor knockout (MOP-KO) mice display baseline hyperalgesia. We have recently identified changes in tissue volume in the periaqueductal gray matter (PAG) using magnetic resonance imaging voxel-based morphometry. Changes in the structure and connectivity of this region might account for some behavior phenotypes in MOP-KO mice, including hyperalgesia. Methods: Adult male MOP-KO and wild-type (WT) mice were studied. Immunohistochemistry was performed to detect microglia, astrocytes, and neurons in the PAG using specific markers: ionized calcium-binding adaptor molecule 1 (Iba-1) for microglia, glial fibrillary acidic protein (GFAP) for astrocytes, and the neuronal nuclei antigen (NeuN; product of the Rbfox3 gene) for neurons, respectively. Cell counting was performed in the four parallel longitudinal columns of the PAG (dorsomedial, dorsolateral, lateral, and ventrolateral) at three different locations from bregma (-3.5, -4.0, and -4.5 mm). Results: The quantitative analysis showed larger numbers of well-distributed Iba1-IR cells (microglia), NeuN-IR cells (neurons), and GFAP-IR areas (astrocytes) at all the anatomically distinct regions examined, namely, the dorsomedial (DM) PAG, dorsolateral (DL) PAG, lateral (L) PAG, and ventrolateral (VL) PAG, in MOP-KO mice than in control mice. Conclusions: The cellular changes in the PAG identified in this paper may underlie aspects of the behavioral alterations produced by MOP receptor deletion, and suggest that alterations in the cellular structure of the PAG may contribute to hyperalgesic states.

  2018, Frontiers in psychiatry, 9, 441 - 441, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Brain hyperserotonemia causes autism-relevant social deficits in mice.

  Miho Tanaka, Atsushi Sato, Shinya Kasai, Yoko Hagino, Hiroko Kotajima-Murakami, Hirofumi Kashii, Yukio Takamatsu, Yasumasa Nishito, Masumi Inagaki, Masashi Mizuguchi, F Scott Hall, George R Uhl, Dennis Murphy, Ichiro Sora, Kazutaka Ikeda

  Background: Hyperserotonemia in the brain is suspected to be an endophenotype of autism spectrum disorder (ASD). Reducing serotonin levels in the brain through modulation of serotonin transporter function may improve ASD symptoms. Methods: We analyzed behavior and gene expression to unveil the causal mechanism of ASD-relevant social deficits using serotonin transporter (Sert) knockout mice. Results: Social deficits were observed in both heterozygous knockout mice (HZ) and homozygous knockout mice (KO), but increases in general anxiety were only observed in KO mice. Two weeks of dietary restriction of the serotonin precursor tryptophan ameliorated both brain hyperserotonemia and ASD-relevant social deficits in Sert HZ and KO mice. The expression of rather distinct sets of genes was altered in Sert HZ and KO mice, and a substantial portion of these genes was also affected by tryptophan depletion. Tryptophan depletion in Sert HZ and KO mice was associated with alterations in the expression of genes involved in signal transduction pathways initiated by changes in extracellular serotonin or melatonin, a derivative of serotonin. Only expression of the AU015836 gene was altered in both Sert HZ and KO mice. AU015836 expression and ASD-relevant social deficits normalized after dietary tryptophan restriction. Conclusions: These findings reveal a Sert gene dose-dependent effect on brain hyperserotonemia and related behavioral sequelae in ASD and a possible therapeutic target to normalize brain hyperserotonemia and ASD-relevant social deficits.

  2018, Molecular autism, 9, 60 - 60, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Association of CYP2D6 polymorphisms and extrapyramidal symptoms in schizophrenia patients receiving risperidone: a retrospective study.

  Takahiro Ito, Kazuhiro Yamamoto, Fuminori Ohsawa, Ikuo Otsuka, Akitoyo Hishimoto, Ichiro Sora, Midori Hirai, Ikuko Yano

  Background: Risperidone is mainly metabolized by cytochrome P450 (CYP) 2D6 in the liver. The gene encoding CYP2D6 is highly polymorphic. The average steady-state plasma concentration of risperidone active moiety is higher in the CYP2D6 intermediate metabolizers (IMs) compared with that in the extensive metabolizers (EMs). An association between drug-induced extrapyramidal symptoms scale (DIEPSS) score and CYP2D6 polymorphisms has not been reported to date. This study investigates the association of CYP2D6 polymorphisms with the severity of extrapyramidal symptoms in schizophrenia patients receiving risperidone therapy. Methods: Schizophrenia patients undergoing risperidone treatment were recruited for the study in the Kobe University Hospital. We evaluated extrapyramidal symptoms of schizophrenia using the DIEPSS. CYP2D6*10 and CYP2D6*14 were analyzed using TaqMan® assays, and CYP2D6*5 was analyzed using the long-PCR method. Patients with CYP2D6*1/*5, *1/*14, *5/*10, *10/*10, and *10/*14 were classified as IMs, and patients with CYP2D6*1/*1 and *1/*10 were classified as EMs. Patients with CYP2D6*5/*5, *5/*14, and *14/*14 were classified as poor metabolizers (PMs). Results: A total of 22 patients were included in the study. No patients were classified as PMs. The dose of risperidone (mg/day) was not significantly different between EMs (n = 15) and IMs (n = 7) (median with the interquartile range: 4.0 (2.0-6.0) vs. 4.0 (2.0-7.0) mg, p = 0.31). The age and disease duration of schizophrenia were not significantly different between the EMs and IMs. The DIEPSS score in the IMs was significantly higher than that in the EMs (median with the interquartile range: 5.0 (3.5-6.5) vs. 0.0 (0.0-3.0), p < 0.001). The multiple regression analysis showed that CYP2D6 IMs is a significant risk factor for the DIEPSS (p < 0.05). Conclusion: Special attentions should be paid to the onset of extrapyramidal symptoms in schizophrenia patients identified as CYP2D6 IM undergoing risperidone therapy.

  2018, Journal of pharmaceutical health care and sciences, 4, 28 - 28, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Rare PDCD11 variations are not associated with risk of schizophrenia in Japan.

  Satoshi Hoya, Yuichiro Watanabe, Akitoyo Hishimoto, Ayako Nunokawa, Naoshi Kaneko, Tatsuyuki Muratake, Naofumi Shinmyo, Ikuo Otsuka, Shujiro Okuda, Emiko Inoue, Hirofumi Igeta, Masako Shibuya, Jun Egawa, Naoki Orime, Ichiro Sora, Toshiyuki Someya

  Nov. 2017, Psychiatry and clinical neurosciences, 71(11) (11), 780 - 788, English, International magazine

  [Refereed]

  Scientific journal


• 衝動制御障害とドパミン系

  SORA ICHIRO

  Lead, Movement Disorder Society of Japan (MDSJ), Oct. 2017, パーキンソン病・運動障害疾患コングレスプログラム・抄録集 11回, 11回, 58 - 58, Japanese

  Symposium


• 当院の電気けいれん療法における実績と報告

  加賀野井, 秀和, SHIROIWA KYOICHI, AOYAMA SHINSUKE, BOKU SHUKEN, OTSUKA IKUO, HISHIMOTO AKITOYO, SORA ICHIRO

  (公社)日本精神神経学会, Sep. 2017, 精神神経学雑誌, 119(9) (9), 696 - 696, Japanese


• 神戸大学医学部附属病院における精神科ショートケア開設後の現状と課題

  神志那 武, TAMIYA HIROKO, BOKU SHUKEN, 村瀬 裕美, 渕脇 綾乃, 干飯 雅昭, HISHIMOTO AKITOYO, SORA ICHIRO

  (公社)日本精神神経学会, Sep. 2017, 精神神経学雑誌, 119(9) (9), 704 - 704, Japanese


• 自殺既遂者におけるテロメア異常短縮(Shorter telomere length in suicide completers)

  大塚 郁夫, 菱本 明豊, 泉 剛, 朴 秀賢, 木村 敦, 張 園, 毛利 健太朗, 岡崎 賢志, 高橋 玄倫, 上野 易弘, 白川 治, 曽良 一郎

  日本生物学的精神医学会・日本神経精神薬理学会, Sep. 2017, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 39回・47回, 156 - 156, English

  Research society


• 視神経膠腫治療の経過中に幻覚妄想、精神運動興奮を認めた下垂体機能低下症の1例

  内田杏子, MATSUYAMA KENICHI, MOURI KENTARO, AOYAMA SHINSUKE, HISHIMOTO AKITOYO, SORA ICHIRO

  (公社)日本精神神経学会, Sep. 2017, 精神神経学雑誌, 119(9) (9), 702 - 702, Japanese


• Rare FBXO18 variations and risk of schizophrenia: Whole-exome sequencing in two parent-affected offspring trios followed by resequencing and case-control studies.

  Satoshi Hoya, Yuichiro Watanabe, Akitoyo Hishimoto, Ayako Nunokawa, Emiko Inoue, Hirofumi Igeta, Ikuo Otsuka, Masako Shibuya, Jun Egawa, Ichiro Sora, Toshiyuki Someya

  Aug. 2017, Psychiatry and clinical neurosciences, 71(8) (8), 562 - 568, English, International magazine

  [Refereed]

  Scientific journal


• Aberrant telomere length and mitochondrial DNA copy number in suicide completers.

  Ikuo Otsuka, Takeshi Izumi, Shuken Boku, Atsushi Kimura, Yuan Zhang, Kentaro Mouri, Satoshi Okazaki, Kyoichi Shiroiwa, Motonori Takahashi, Yasuhiro Ueno, Osamu Shirakawa, Ichiro Sora, Akitoyo Hishimoto

  Jun. 2017, Scientific reports, 7(1) (1), 3176 - 3176, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Neurocognitive profile of euthymic Japanese patients with bipolar disorder.

  Nozomi Ishisaka, Satomi Shimano, Tomofumi Miura, Keisuke Motomura, Machiko Horii, Hisako Imanaga, Junji Kishimoto, Yasuhiro Kaneda, Ichiro Sora, Shigenobu Kanba

  Blackwell Publishing, Jun. 2017, Psychiatry and clinical neurosciences, 71(6) (6), 373 - 382, English, International magazine

  [Refereed]

  Scientific journal


• Distinct Roles of Opioid and Dopamine Systems in Lateral Hypothalamic Intracranial Self-Stimulation.

  Soichiro Ide, Takehiro Takahashi, Yukio Takamatsu, George R Uhl, Hiroaki Niki, Ichiro Sora, Kazutaka Ikeda

  Oxford University Press, May 2017, The international journal of neuropsychopharmacology, 20(5) (5), 403 - 409, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Optimizing outcomes in clozapine rechallenge following neutropenia using human leukocyte antigen typing: A case report.

  Naruhisa Yamaki, Akitoyo Hishimoto, Ikuo Otsuka, Toru Sasada, Shuken Boku, Takeo Saito, Yuka Yasuda, Hidenaga Yamamori, Masashi Ikeda, Manabu Ikeda, Ichiro Sora, Nakao Iwata, Ryota Hashimoto

  Apr. 2017, Psychiatry and clinical neurosciences, 71(4) (4), 289 - 290, English, International magazine

  [Refereed]


• A ssociation study of MIF promoter polymorphisms with suicide completers in the Japanese population

  Naofumi Shimmyo, Akitoyo Hishimoto, Ikuo Otsuka, Satoshi Okazaki, Shuken Boku, Kentaro Mouri, Tadasu Horai, Motonori Takahashi, Yasuhiro Ueno, Osamu Shirakawa, Ichiro Sora

  Last, 2017, NEUROPSYCHIATRIC DISEASE AND TREATMENT, 13, 899 - 908, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The cell cycle-related genes as biomarkers for schizophrenia.

  Satoshi Okazaki, Shuken Boku, Ikuo Otsuka, Kentaro Mouri, Shinsuke Aoyama, Kyoichi Shiroiwa, Ichiro Sora, Aiko Fujita, Yutaka Shirai, Osamu Shirakawa, Masahiro Kokai, Akitoyo Hishimoto

  Oct. 2016, Progress in neuro-psychopharmacology & biological psychiatry, 70, 85 - 91, English, International magazine

  [Refereed]

  Scientific journal


• Contribution of Translational Genetic Research to Our Understanding of Nicotine Dependence

  F. S. Hall, Y. Arime, Y. Saber, I. Sora

  Elsevier Inc., Sep. 2016, Negative Affective States and Cognitive Impairments in Nicotine Dependence, 111 - 132, English, Co-authored internationally

  [Refereed]

  In book


• 男性アルコール依存症患者における骨密度減少のリスクファクターに関する横断研究(The risk factors of low bone mineral density in male alcoholic patients: cross-sectional study)

  蓬莱 政, 菱本 明豊, 毛利 健太朗, 朴 秀賢, 江口 典臣, 新名 尚史, 木村 敦, 曽良 一郎

  Last, (一社)日本神経精神薬理学会, Jul. 2016, 日本神経精神薬理学会年会プログラム・抄録集, 46回, 223 - 223, English


• 好中球減少にてクロザピンを一時中止したのち再投与した統合失調症の一例

  大塚郁夫, 笹田徹, 菱本明豊, Ichiro Sora

  Last, (一社)日本神経精神薬理学会, Jul. 2016, 日本神経精神薬理学会年会プログラム・抄録集 46回, 46回, 164 - 164, Japanese


• ニコチン依存におけるCDH13の役割 マウス神経前駆細胞と統合失調症臨床サンプルを用いた解析(Possible role of CDH13 in nicotine dependence: Investigations on mouse neural progenitors and schizophrenia patients)

  大塚 郁夫, 菱本 明豊, 朴 秀賢, 岡崎 賢志, 毛利 健太朗, 曽良 一郎

  Last, (一社)日本神経精神薬理学会, Jul. 2016, 日本神経精神薬理学会年会プログラム・抄録集, 46回, 220 - 220, English


• KIF17の脳内タンパク減少とミスセンス変異は統合失調症と関連する(A decrease in protein level and a missense polymorphism of KIF17 are associated with schizophrenia)

  菱本 明豊, 毛利 健太朗, ラッタアッパ・ワラパット, 朴 秀賢, 曽良 一郎

  Last, (一社)日本神経精神薬理学会, Jul. 2016, 日本神経精神薬理学会年会プログラム・抄録集, 46回, 210 - 210, English


• [Biological review of completed suicide].

  Ikuo Otsuka, Ichiro Sora, Akitoyo Hishimoto

  Japanese Society of Neuropsychopharmacology, Jun. 2016, Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 36(3) (3), 55 - 61, Japanese, Domestic magazine

  [Refereed]

  Scientific journal


• Methamphetamine induced changes of monoamine neurotransmission in 5-HT1B KO mice

  Yuki Moriya, Yoko Hagino, Scott F. Hall, Rene Hen, Kazutaka Ikeda, Yoshiyuki Kasahara, Ichiro Sora, George R. Uhl

  Jun. 2016, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 19, 159 - 159, English


• Effects of chronic tryptophan depletion on autism spectrum disorder like behaviors in serotonin transporter knockout and heterozygous mice

  Miho Tanaka, Atsushi Sato, Yoko Hagino, Ichiro Sora, Dennis Murphy, Kazutaka Ikeda

  Jun. 2016, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 19, 171 - 171, English


• The risk factors of low bone mineral density in male alcoholic patients: cross-sectional study

  Tadasu Horai, Shunken Boku, Noriomi Eguchi, Akitoyo Hishimoto, Atsushi Kimura, Kentaro Mori, Naofumi Shinmyo, Ichiro Sora

  Jun. 2016, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 19, 164 - 164, English


• Possible role of CDH13 in nicotine dependence: Investigations on mouse neural progenitors and schizophrenia patients

  Ikuo Otsuka, Akitoyo Hishimoto, Shuken Boku, Satoshi Okazaki, Kentaro Mouri, Ichiro Sora

  Jun. 2016, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 19, 160 - 160, English


• A decrease in protein level and a missense polymorphism of KIF17 are associated with schizophrenia

  Akityo Hishimoto, Shuken Boku, Hiroki Ishiguro, Kentaro Mori, Woraphat Ratta-apha, Ichiro Sora

  Jun. 2016, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 19, 213 - 213, English


• Genetic polymorphisms commonly associated with sensitivity to addictive substances

  Ikeda Kazutaka, Nishizawa Daisuke, Fukuda Ken-ichi, Hayashida Masakazu, Higuchi Susumu, Sugimura Haruhiko, Sora Ichiro

  Last, Jun. 2016, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 19, 28

  [Refereed]


• Phencyclidine (Angel Dust, PCP) and Fos Immunoreactivity

  Hideko Yamamoto, Wakako Sawada, Etsuko Kamegaya, Yoko Hagino, Kazutaka Ikeda, Ichiro Sora, Masayoshi Mishina, Toshifumi Yamamoto

  Elsevier Inc., Apr. 2016, Neuropathology of Drug Addictions and Substance Misuse, 2, 604 - 613, English

  [Refereed]

  In book


• Slow synaptic transmission mediated by TRPV1 channels in CA3 interneurons of the hippocampus.

  Noriomi Eguchi, Akitoyo Hishimoto, Ichiro Sora, Masahiro Mori

  Mar. 2016, Neuroscience letters, 616, 170 - 6, English, International magazine

  [Refereed]

  Scientific journal


• Rare truncating variations and risk of schizophrenia: Whole-exome sequencing in three families with affected siblings and a three-stage follow-up study in a Japanese population.

  Yuichiro Watanabe, Ayako Nunokawa, Masako Shibuya, Masashi Ikeda, Akitoyo Hishimoto, Kenji Kondo, Jun Egawa, Naoshi Kaneko, Tatsuyuki Muratake, Takeo Saito, Satoshi Okazaki, Ayu Shimasaki, Hirofumi Igeta, Emiko Inoue, Satoshi Hoya, Takuro Sugai, Ichiro Sora, Nakao Iwata, Toshiyuki Someya

  Jan. 2016, Psychiatry research, 235, 13 - 8, English, International magazine

  [Refereed]

  Scientific journal


• 当科における「神経性食欲不振症の教育入院」プログラムの紹介

  勝又知子, 井上貴裕, 原口千代, 奥小路明子, 内田杏子, 田宮裕子, Ichiro Sora

  Last, (一社)日本総合病院精神医学会, Jan. 2016, 総合病院精神医学, 28(1) (1), 62 - 63, Japanese


• A decrease in protein level and a missense polymorphism of KIF17 are associated with schizophrenia.

  Woraphat Ratta-Apha, Kentaro Mouri, Shuken Boku, Hiroki Ishiguro, Satoshi Okazaki, Ikuo Otsuka, Ichiro Sora, Tadao Arinami, Osamu Shirakawa, Akitoyo Hishimoto

  Dec. 2015, Psychiatry research, 230(2) (2), 424 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Region-Specific Dendritic Spine Loss of Pyramidal Neurons in Dopamine Transporter Knockout Mice

  Ichiro Sora, Yosefu Arime, Frank Hall, George R. Uhl, Yoshiyuki Kasahara

  Dec. 2015, NEUROPSYCHOPHARMACOLOGY, 40, S222 - S222, English


• Association analysis of the HLA-DRB1*01 and HLA-DRB1*04 with schizophrenia by tag SNP genotyping in the Japanese population.

  Woraphat Ratta-apha, Shuken Boku, Kentaro Mouri, Satoshi Okazaki, Ikuo Otsuka, Yuichiro Watanabe, Ayako Nunokawa, Toshiyuki Someya, Osamu Shirakawa, Ichiro Sora, Akitoyo Hishimoto

  Sep. 2015, Psychiatry research, 229(1-2) (1-2), 627 - 8, English, International magazine

  [Refereed]

  Scientific journal


• 治療域濃度リチウムによる単球系細胞における遺伝子発現への影響

  兪 志前, 小野 千晶, 相場 節也, 菊地 淑恵, 曽良 一郎, 松岡 洋夫, 富田 博秋

  日本生物学的精神医学会・日本神経精神薬理学会, Sep. 2015, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 37回・45回, 194 - 194, Japanese

  [Refereed]


• 薬剤師、若手医師向け臨床神経精神薬理 モノアミン神経伝達と向精神薬

  Ichiro Sora

  Sep. 2015, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集37回・45回, 131, Japanese

  Research society


• 統合失調症における細胞周期関連遺伝子に着目した3段階mRNA発現解析(A three-stage mRNA expression study to identify cell cycle-related genes associated with schizophrenia)

  岡崎 賢志, 菱本 明豊, 朴 秀賢, 毛利 健太朗, 白岩 恭一, 大塚 郁夫, 白井 豊, 藤田 愛子, 白川 治, 湖海 正尋, 曽良 一郎

  Last, 日本生物学的精神医学会・日本神経精神薬理学会, Sep. 2015, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 37回・45回, 172 - 172, English

  Symposium


• 統合失調症におけるCadherin13遺伝子多型解析(Association analysis of the Cadherin 13 gene with schizophrenia in the Japanese population)(英語)

  大塚郁夫, 渡部雄一郎, Hishimoto Akitoyo, 朴秀賢, 毛利健太朗, 白岩恭一, 岡崎賢志, 布川綾子, 白川治, 染矢俊幸, Ichiro Sora

  Sep. 2015, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集37回・45回, 201, Japanese

  Symposium


• Factors predicting work outcome in Japanese patients with schizophrenia: role of multiple functioning levels.

  Chika Sumiyoshi, Philip D Harvey, Manabu Takaki, Yuko Okahisa, Taku Sato, Ichiro Sora, Keith H Nuechterlein, Kenneth L Subotnik, Tomiki Sumiyoshi

  Elsevier Inc., Sep. 2015, Schizophrenia research. Cognition, 2(3) (3), 105 - 112, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies.

  Daisuke Nishizawa, Shinya Kasai, Junko Hasegawa, Naomi Sato, Hidetaka Yamada, Fumihiko Tanioka, Makoto Nagashima, Ryoji Katoh, Yasuo Satoh, Megumi Tagami, Hiroshi Ujike, Norio Ozaki, Toshiya Inada, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Mitsuhiko Yamada, Naoki Kondo, Moo-Jun Won, Nobuya Naruse, Kumi Uehara-Aoyama, Masanari Itokawa, Kazutaka Ohi, Ryota Hashimoto, Kumpei Tanisawa, Tomio Arai, Seijiro Mori, Motoji Sawabe, Makiko Naka-Mieno, Yoshiji Yamada, Miki Yamada, Noriko Sato, Masaaki Muramatsu, Masashi Tanaka, Yoko Irukayama-Tomobe, Yuki C Saito, Takeshi Sakurai, Masakazu Hayashida, Haruhiko Sugimura, Kazutaka Ikeda

  BACKGROUND: Many genetic and environmental factors are involved in the etiology of nicotine dependence. Although several candidate gene variations have been reported by candidate gene studies or genome-wide association studies (GWASs) to be associated with smoking behavior and the vulnerability to nicotine dependence, such studies have been mostly conducted with subjects with European ancestry. However, genetic factors have rarely been investigated for the Japanese population as GWASs. To elucidate genetic factors involved in nicotine dependence in Japanese, the present study comprehensively explored genetic contributors to nicotine dependence by using whole-genome genotyping arrays with more than 200,000 markers in Japanese subjects. RESULTS: The subjects for the GWAS and replication study were 148 and 374 patients, respectively. A two-stage GWAS was conducted using the Fagerström Test for Nicotine Dependence (FTND), Tobacco Dependence Screener (TDS), and number of cigarettes smoked per day (CPD) as indices of nicotine dependence. For the additional association analyses, patients who underwent major abdominal surgery, patients with methamphetamine dependence/psychosis, and healthy subjects with schizotypal personality trait data were recruited. Autopsy specimens with various diseases were also evaluated. After the study of associations between more than 200,000 marker single-nucleotide polymorphisms (SNPs) and the FTND, TDS, and CPD, the nonsynonymous rs2653349 SNP (located on the gene that encodes orexin [hypocretin] receptor 2) was selected as the most notable SNP associated with FTND, with a p value of 0.0005921 in the two-stage GWAS. This possible association was replicated for the remaining 374 samples. This SNP was also associated with postoperative pain, the initiation of methamphetamine use, schizotypal personality traits, and susceptibility to goiter. CONCLUSIONS: Although the p value did not reach a conventional genome-wide level of significance in our two-stage GWAS, we obtained significant results in the subsequent analyses that suggest that the rs2653349 SNP (Val308Ile) could be a genetic factor that is related to nicotine dependence and possibly pain, schizotypal personality traits, and goiter in the Japanese population.

  Aug. 2015, Molecular brain, 8(1) (1), 50 - 50, English, International magazine

  [Refereed]

  Scientific journal


• 結核性髄膜炎に罹患後、多彩な精神症状を認めた1例

  古野和歌子, 青山慎介, Ichiro Sora

  Last, Aug. 2015, 精神神経学雑誌, 117(8号) (8号), 683, Japanese

  [Refereed]

  Scientific journal


• 危険ドラッグの連続使用により幻覚・精神運動興奮を呈した1例

  山木愛久, 田宮裕子, Ichiro Sora

  Last, Aug. 2015, 精神神経学雑誌, 117(8号) (8号), 688, Japanese

  [Refereed]

  Scientific journal


• 危険ドラッグの臨床症状への影響および遺伝子多型との関連の検討

  岡崎賢志, Hishimoto Akitoyo, 朴秀賢, 毛利健太朗, 竹村幸洋, 麻生克郎, 山本訓也, Ichiro Sora

  Last, (一社)日本アルコール・アディクション医学会, Aug. 2015, 日本アルコール・薬物医学会雑誌, 50(4) (4), 230 - 230, Japanese

  Research society


• Methylone-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters.

  Ying-Shan Piao, Frank Scott Hall, Yuki Moriya, Miki Ito, Arihisa Ohara, Ruri Kikura-Hanajiri, Yukihiro Goda, Klaus-Peter Lesch, Dennis L Murphy, George R Uhl, Ichiro Sora

  Last, Jun. 2015, Behavioural pharmacology, 26(4) (4), 345 - 52, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Sex differences in the effects of adolescent social deprivation on alcohol consumption in μ-opioid receptor knockout mice.

  Yuki Moriya, Yoshiyuki Kasahara, F Scott Hall, Yasufumi Sakakibara, George R Uhl, Hiroaki Tomita, Ichiro Sora

  Last, Apr. 2015, Psychopharmacology, 232(8) (8), 1471 - 82, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• FUNCTIONAL RECOVERY IN PATIENTS WITH SCHIZOPHRENIA: PREDICTING FACTORS FOR WORK OUTCOME

  Chika Sumiyoshi, Manabu Takaki, Yuko Okahisa, Taku Sato, Ichiro Sora, Keith H. Nuechterlein, Kenneth N. Subotnik, Philip D. Harvey, Tomiki Sumiyoshi

  Mar. 2015, SCHIZOPHRENIA BULLETIN, 41, S192 - S192, English


• 血清マイクロRNAの定性的解析による統合失調症の診断・病態マーカーの探索

  Hishimoto Akitoyo, 毛利健太朗, 朴秀賢, 岡崎賢志, 白岩恭一, Ichiro Sora

  Last, (公財)先進医薬研究振興財団, Mar. 2015, 先進医薬研究振興財団研究成果報告集, 2014年度(2014年度) (2014年度), 24 - 25, Japanese

  Research society


• 反復性うつ病の入院治療中に多飲水行動を呈した1例

  小林 明美, 石丸 綾子, 笹田 徹, 白岩 恭一, 毛利 健太朗, 山本 泰司, 菱本 明豊, 田中 究, Ichiro Sora

  Last, Feb. 2015, 精神神経学雑誌, 117(2号) (2号), 161, Japanese

  Research society


• 自殺企図の原因となった難治性胃痛に対して機能性ディスペプシアと診断し、うつ病との並行治療により改善を認めた1例

  高田 佳, 奥小路 明子, 田宮 裕子, 田中 究, Ichiro Sora

  Last, Feb. 2015, 精神神経学雑誌, 117(2号) (2号), 158, Japanese

  Research society


• Therapeutic concentration of lithium stimulates complement C3 production in dendritic cells and microglia via GSK-3 inhibition.

  Zhiqian Yu, Chiaki Ono, Setsuya Aiba, Yoshie Kikuchi, Ichiro Sora, Hiroo Matsuoka, Hiroaki Tomita

  Feb. 2015, Glia, 63(2) (2), 257 - 70, English, International magazine

  [Refereed]

  Scientific journal


• Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment.

  Moe Igari, Hao-Wei Shen, Yoko Hagino, Setsu Fukushima, Yoshiyuki Kasahara, Klaus-Peter Lesch, Dennis L Murphy, Frank Scott Hall, George R Uhl, Kazutaka Ikeda, Nobuo Yaegashi, Ichiro Sora

  Last, Feb. 2015, Behavioural pharmacology, 26(1-2) (1-2), 167 - 79, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and Shows Associations with Dependence-Like Behavior in Genomic Association Study

  K. Uno, D. Nishizawa, S. Seo, K. Takayama, S. Matsumura, N. Sakai, K. Ohi, T. Nabeshima, R. Hashimoto, N. Ozaki, J. Hasegawa, N. Sato, F. Tanioka, H. Sugimura, K. -I. Fukuda, S. Higuchi, H. Ujike, T. Inada, N. Iwata, I. Sora, M. Iyo, N. Kondo, M. -J. Won, N. Naruse, K. Uehara-Aoyama, M. Itokawa, M. Yamada, K. Ikeda, Y. Miyamoto, A. Nitta

  2015, CURRENT MOLECULAR MEDICINE, 15(3) (3), 265 - 274, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Region-Specific Dendritic Spine Loss of Pyramidal Neurons in Dopamine Transporter Knockout Mice

  Y. Kasahara, Y. Arime, F. S. Hall, G. R. Uhl, I. Sora

  Last, 2015, CURRENT MOLECULAR MEDICINE, 15(3) (3), 237 - 244, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Improvement of Learning and Increase in Dopamine Level in the Frontal Cortex by Methylphenidate in Mice Lacking Dopamine Transporter

  Y. Takamatsu, Y. Hagino, A. Sato, T. Takahashi, S. Y. Nagasawa, Y. Kubo, M. Mizuguchi, G. R. Uhl, I. Sora, K. Ikeda

  Last, 2015, CURRENT MOLECULAR MEDICINE, 15(3) (3), 245 - 252, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• 統合失調症妊産婦の育児支援の有用性についての1例

  奥小路 明子, 佐々木 雅明, 松井 裕介, Ichiro Sora

  Last, Jan. 2015, 精神神経学雑誌, 117(1号) (1号), 58, Japanese

  Research society


• 甲状腺機能亢進により幻覚・意識障害を呈した症状精神病の1例

  山木 愛久, 西田 典充, 白岩 恭一, 田宮 裕子, 田中 究, Ichiro Sora

  Last, Jan. 2015, 精神神経学雑誌, 117(1号) (1号), 57 - 58, Japanese

  Research society


• 刑事精神鑑定において初めて広汎性発達障害と診断した1例

  佐々木 雅明, 岩本 直子, 笹田 徹, 松井 裕介, 田中 究, Ichiro Sora

  Last, Jan. 2015, 精神神経学雑誌, 117(1号) (1号), 59, Japanese

  Research society


• Specific regions display altered grey matter volume in μ-opioid receptor knockout mice: MRI voxel-based morphometry.

  Kazumasu Sasaki, Akira Sumiyoshi, Hiroi Nonaka, Yoshiyuki Kasahara, Kazutaka Ikeda, F Scott Hall, George R Uhl, Masahiko Watanabe, Ryuta Kawashima, Ichiro Sora

  Last, Jan. 2015, British journal of pharmacology, 172(2) (2), 654 - 67, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Association analysis of the Cadherin13 gene with schizophrenia in the Japanese population.

  Ikuo Otsuka, Yuichiro Watanabe, Akitoyo Hishimoto, Shuken Boku, Kentaro Mouri, Kyoichi Shiroiwa, Satoshi Okazaki, Ayako Nunokawa, Osamu Shirakawa, Toshiyuki Someya, Ichiro Sora

  Last, 2015, Neuropsychiatric disease and treatment, 11, 1381 - 93, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 神戸大学医学部附属病院におけるblonanserinの投与状況について

  白岩 恭一, 毛利 健太朗, 笹田 徹, 大塚 郁夫, 大本 暢子, Hishimoto Akitoyo, Ichiro Sora

  Last, Nov. 2014, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集24回・44回, 174, Japanese

  [Refereed]

  Symposium


• ドーパミントランスポーター欠損マウスにおけるメチルフェデートとアトモキセチンの週齢別効果(The effectiveness of methylphenidate and atomoxetine in the dopamine transporter knockout(DAT-KO) mice by postnatal development)(英語)

  長澤 セーラ, 高松 幸雄, 佐藤 敦志, 柏井 洋文, 久保 有美子, 水口 雅, Ichiro Sora, 池田 和隆

  Nov. 2014, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集 24回・44回, 206, Japanese

  Research society


• Developmental alterations in anxiety and cognitive behavior in serotonin transporter mutant mice.

  Yasufumi Sakakibara, Yoshiyuki Kasahara, F Scott Hall, Klaus-Peter Lesch, Dennis L Murphy, George R Uhl, Ichiro Sora

  Last, Oct. 2014, Psychopharmacology, 231(21) (21), 4119 - 33, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• SEX DIFFERENCES IN THE EFFECTS OF CHRONIC SOCIAL ISOLATION ON ALCOHOL CONSUMPTION IN MU-OPIOID RECEPTOR KNOCKOUT MICE

  Y. Moriya, Y. Kasahara, F. S. Hall, G. R. Uhl, I. Sora

  Sep. 2014, ALCOHOL AND ALCOHOLISM, 49, English


• 慢性疼痛に対しduloxetineが奏効した4症例の検討

  大塚 郁夫, 白岩 恭一, 毛利 健太朗, 笹田 徹, Hishimoto Akitoyo, Ichiro Sora

  Last, Aug. 2014, 臨床精神薬理, 17(8号) (8号), 1151 - 1156, Japanese

  [Refereed]

  Scientific journal


• GABAergic neurons in the ventral tegmental area receive dual GABA/enkephalin-mediated inhibitory inputs from the bed nucleus of the stria terminalis.

  Takehiro Kudo, Kohtarou Konno, Motokazu Uchigashima, Yuchio Yanagawa, Ichiro Sora, Masabumi Minami, Masahiko Watanabe

  Jun. 2014, The European journal of neuroscience, 39(11) (11), 1796 - 809, English, International magazine

  [Refereed]

  Scientific journal


• Association analysis of putative cis-acting polymorphisms of interleukin-19 gene with schizophrenia.

  Satoshi Okazaki, Yuichiro Watanabe, Akitoyo Hishimoto, Toru Sasada, Kentaro Mouri, Kyoichi Shiroiwa, Noriomi Eguchi, Woraphat Ratta-Apha, Ikuo Otsuka, Ayako Nunokawa, Naoshi Kaneko, Masako Shibuya, Toshiyuki Someya, Osamu Shirakawa, Ichiro Sora

  Last, Apr. 2014, Progress in neuro-psychopharmacology & biological psychiatry, 50, 151 - 6, English, International magazine

  [Refereed]

  Scientific journal


• A rare MIR138-2 gene variation is associated with schizophrenia in a Japanese population.

  Yuichiro Watanabe, Masako Shibuya, Ayako Nunokawa, Naoshi Kaneko, Hirofumi Igeta, Jun Egawa, Toshiyuki Someya, Akitoyo Hishimoto, Kentaro Mouri, Ichiro Sora

  Last, Mar. 2014, Psychiatry research, 215(3) (3), 801 - 2, English, International magazine

  [Refereed]

  Scientific journal


• Haplotype analysis of the DISC1 Ser704Cys variant in Japanese suicide completers.

  Woraphat Ratta-apha, Akitoyo Hishimoto, Kentaro Mouri, Kyoichi Shiroiwa, Toru Sasada, Masakuni Yoshida, Satoshi Okazaki, Irwan Supriyanto, Migiwa Asano, Yasuhiro Ueno, Osamu Shirakawa, Ichiro Sora

  Last, Jan. 2014, Psychiatry research, 215(1) (1), 249 - 51, English, International magazine

  [Refereed]

  Scientific journal


• Cocaine-related disorders

  F. Scott Hall, Ichiro Sora

  Cambridge University Press, Jan. 2014, Behavioral Genetics of the Mouse Volume II: Genetic Mouse Models of Neurobehavioral Disorders, 350 - 378, English

  In book


• The involvement of glucocorticoids in psychological stress-induced exacerbations of experimental allergic asthma.

  Kaori Okuyama, Kazuhisa Dobashi, Tomomitsu Miyasaka, Naoki Yamazaki, Toshiaki Kikuchi, Ichiro Sora, Motoaki Takayanagi, Hirohito Kita, Isao Ohno

  2014, International archives of allergy and immunology, 163(4) (4), 297 - 306, English, International magazine

  [Refereed]

  Scientific journal


• 認知行動療法が奏効した重度神経性食欲不振症の1例

  原口 千代, 勝又 知子, 石丸 綾子, 玉岡 文子, 田宮 裕子, 田中 究, Ichiro Sora

  Last, Jan. 2014, 総合病院精神医学, 26(1号) (1号), 90 - 91, Japanese

  [Refereed]

  Symposium


• 軽度知的障害を合併しclozapineが奏功しなかった統合失調症の1例

  山木 愛久, 白岩 恭一, 山本 泰司, 田中 究, Ichiro Sora

  Last, Jan. 2014, 精神神経学雑誌, 116(1号) (1号), 90, Japanese

  Symposium


• 我々はいかにして彼を同意無能力と判定したか 慢性腎臓病を伴う統合失調症患者の透析導入検討に際して

  宋 龍平, 毛利 健太郎, 田宮 裕子, 田中 究, Ichiro Sora

  Last, Jan. 2014, 精神神経学雑誌, 116(1号) (1号), 91, Japanese

  Symposium


• Genome-wide association study identifies a potent locus associated with human opioid sensitivity

  D. Nishizawa, K. Fukuda, S. Kasai, J. Hasegawa, Y. Aoki, A. Nishi, N. Saita, Y. Koukita, M. Nagashima, R. Katoh, Y. Satoh, M. Tagami, S. Higuchi, H. Ujike, N. Ozaki, T. Inada, N. Iwata, I. Sora, M. Iyo, N. Kondo, M-J Won, N. Naruse, K. Uehara-Aoyama, M. Itokawa, M. Koga, T. Arinami, Y. Kaneko, M. Hayashida, K. Ikeda

  Jan. 2014, MOLECULAR PSYCHIATRY, 19(1) (1), 55 - 62, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Decreased vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) function in knockout mice affects aging of dopaminergic systems

  F. S. Hall, K. Itokawa, A. Schmitt, R. Moessner, I. Sora, K. P. Lesch, G. R. Uhl

  Jan. 2014, NEUROPHARMACOLOGY, 76(Pt.A) (Pt.A), 146 - 155, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout.

  Frank Scott Hall, Ichiro Sora, René Hen, George R Uhl

  2014, PloS one, 9(12) (12), e115009, English, International magazine

  [Refereed]

  Scientific journal


• Association analysis of the DISC1 gene with schizophrenia in the Japanese population and DISC1 immunoreactivity in the postmortem brain.

  Woraphat Ratta-Apha, Akitoyo Hishimoto, Kentaro Mouri, Kyoichi Shiroiwa, Toru Sasada, Masakuni Yoshida, Irwan Supriyanto, Yasuhiro Ueno, Migiwa Asano, Osamu Shirakawa, Hideru Togashi, Yoshimi Takai, Ichiro Sora

  Last, Dec. 2013, Neuroscience research, 77(4) (4), 222 - 7, English, International magazine

  [Refereed]

  Scientific journal


• A short version of the measurement and treatment research to improve cognition in schizophrenia consensus cognitive battery.

  Yasuhiro Kaneda, Ichiro Sora

  Last, Nov. 2013, Schizophrenia research, 150(2-3) (2-3), 600 - 1, English, International magazine

  [Refereed]

  Scientific journal


• Association study of BDNF with completed suicide in the Japanese population.

  Woraphat Ratta-Apha, Akitoyo Hishimoto, Masakuni Yoshida, Yasuhiro Ueno, Migiwa Asano, Osamu Shirakawa, Ichiro Sora

  Last, Oct. 2013, Psychiatry research, 209(3) (3), 734 - 6, English, International magazine

  [Refereed]

  Scientific journal


• Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia.

  Masashi Ikeda, Yuko Okahisa, Branko Aleksic, Mujun Won, Naoki Kondo, Nobuya Naruse, Kumi Aoyama-Uehara, Ichiro Sora, Masaomi Iyo, Ryota Hashimoto, Yoshiya Kawamura, Nao Nishida, Taku Miyagawa, Masatoshi Takeda, Tsukasa Sasaki, Katsushi Tokunaga, Norio Ozaki, Hiroshi Ujike, Nakao Iwata

  Sep. 2013, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(10) (10), 1864 - 70, English, International magazine

  [Refereed]

  Scientific journal


• 依存のゲノム科学 テーラーメイド依存治療に向けて 覚せい剤依存・精神病の遺伝的脆弱性要因

  Ichiro Sora

  Aug. 2013, 日本アルコール・薬物医学会雑誌, 48(4号) (4号), 97, Japanese

  Research society


• Impaired cliff avoidance reaction in dopamine transporter knockout mice.

  Motoyasu Yamashita, Yasufumi Sakakibara, F Scott Hall, Yohtaro Numachi, Sumiko Yoshida, Hideaki Kobayashi, Osamu Uchiumi, George R Uhl, Yoshiyuki Kasahara, Ichiro Sora

  Last, Jun. 2013, Psychopharmacology, 227(4) (4), 741 - 9, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• MATRICSコンセンサス認知機能評価バッテリー日本語版の計量心理学的特性

  兼田 康宏, 大森 哲郎, 岡久 祐子, 住吉 太幹, 朴 盛弘, 上岡 義典, 高木 学, 西山 志満子, 中込 和幸, Ichiro Sora

  Last, (公社)日本精神神経学会, May 2013, 精神神経学雑誌, (2013特別) (2013特別), S - 629, Japanese

  Research society


• Measurement and Treatment Research toImprove Cognition in Schizophrenia Consensus Cognitive Battery: validation of the Japanese version.

  Yasuhiro Kaneda, Tetsuro Ohmori, Yuko Okahisa, Tomiki Sumiyoshi, Shenghong Pu, Yoshinori Ueoka, Manabu Takaki, Kazuyuki Nakagome, Ichiro Sora

  Last, Apr. 2013, Psychiatry and clinical neurosciences, 67(3) (3), 182 - 8, English, International magazine

  [Refereed]

  Scientific journal


• Exclusive expression of VMAT2 in noradrenergic neurons increases viability of homozygous VMAT2 knockout mice.

  Arihisa Ohara, Yoshiyuki Kasahara, Hideko Yamamoto, Harumi Hata, Hideaki Kobayashi, Yohtaro Numachi, Ichiro Miyoshi, F Scott Hall, George R Uhl, Kazutaka Ikeda, Ichiro Sora

  Last, Mar. 2013, Biochemical and biophysical research communications, 432(3) (3), 526 - 32, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• The role of serotonin in the effects of psychostimulant drugs: Behavioral studies of addictionand abuse-related phenotypes in knockout mice

  Yuki Moriya, Frank Scott Hall, Ichiro Sora

  Nova Science Publishers, Inc., Mar. 2013, Serotonin: Biosynthesis, Regulation and Health Implications, 191 - 212, English

  In book


• Active behaviours produced by antidepressants and opioids in the mouse tail suspension test.

  Esther Berrocoso, Kazutaka Ikeda, Ichiro Sora, George R Uhl, Pilar Sánchez-Blázquez, Juan Antonio Mico

  Feb. 2013, The international journal of neuropsychopharmacology, 16(1) (1), 151 - 62, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine.

  Osamu Uchiumi, Yoshiyuki Kasahara, Asami Fukui, F Scott Hall, George R Uhl, Ichiro Sora

  Last, Jan. 2013, Neuropharmacology, 64, 348 - 56, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.

  Seiji Hayashizaki, Shinobu Hirai, Yumi Ito, Yoshiko Honda, Yosefu Arime, Ichiro Sora, Haruo Okado, Tohru Kodama, Masahiko Takada

  2013, PloS one, 8(10) (10), e75975, English, International magazine

  [Refereed]

  Scientific journal


• リチウムの単球系細胞における免疫関連遺伝子の発現誘導(Therapeutic concentration of lithium stimulates immune related gene expressions in differentiated monocytic cells)

  兪 志前, 小野 千晶, 相場 節也, 曽良 一郎, 富田 博秋

  日本臨床精神神経薬理学会・日本神経精神薬理学会, Oct. 2012, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 22回・42回, 195 - 195, English

  [Refereed]


• Involvement of the frontal lobe and executive function in deception: A NIRS study

  M. Sato, S. Miyazawa, D. Suzuki, S. Iwasaki, I. Sora

  Sep. 2012, INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 85(3) (3), 415 - 415, English


• GENETIC VULNERABILITY OF METHAMPHETAMINE ADDICTION

  I. Sora

  Sep. 2012, ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 36, 28A - 28A, English


• MCCB日本語版による社会生活評価

  曽良一郎, 宮澤志保, 東海林渉, 佐藤拓, 住吉チカ, 住吉太幹, 兼田康宏, 上埜高志, 大森哲郎, 中込和幸, 佐藤博俊, 伊藤文晃, 松岡洋夫

  May 2012, 厚生労働科学研究費補助金（障害者対策総合研究事業（精神障害分野））「統合失調症における社会生活機能障害の評価・支援－MATRICS-CCB日本語版による認知機能障害の評価と治療計画への応用－平成23年度総括・分担研究報告書（研究代表者：曽良一郎）, 5 - 16, Japanese

  Research society


• MCCB日本語版による認知機能評価と社会生活機能について

  曽良一郎, 宮澤志保, 東海林渉, 佐藤拓, 住吉チカ, 住吉太幹, 兼田康宏, 上埜高志, 大森哲郎, 中込和幸, 佐藤博俊, 伊藤文晃, 松岡洋夫

  May 2012, 厚生労働科学研究費補助金（障害者対策総合研究事業（精神障害分野））「統合失調症における社会生活機能障害の評価・支援－MATRICS-CCB日本語版による認知機能障害の評価と治療計画への応用－平成21~23年度総合研究報告書（研究代表者：曽良一郎）, 7 - 23, Japanese

  Research society


• [Evaluation of therapy for schizophrenic patients with cognitive disorder].

  Ichiro Sora

  Nov. 2011, Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 31(5-6) (5-6), 239 - 239, Japanese, Domestic magazine

  [Refereed]

  Scientific journal


• [Neuronal development of the hyperdopaminergic animal model].

  Yoshiyuki Kasahara, Yosefu Arime, Yumiko Kubo, Asami Fukui, Ichiro Sora

  Last, 5-6, Nov. 2011, Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 31(5-6) (5-6), 195 - 9, Japanese, Domestic magazine

  [Refereed]

  Scientific journal


• [Catecholamine neurotransmission].

  Ichiro Sora

  Oct. 2011, Nihon rinsho. Japanese journal of clinical medicine, 69 Suppl 8, 224 - 7, Japanese, Domestic magazine

  [Refereed]

  Scientific journal


• Decreased response to social defeat stress in mu-opioid-receptor knockout mice

  Hiroshi Komatsu, Arihisa Ohara, Kazumasu Sasaki, Hiromi Abe, Hisaki Hattori, F. Scott Hall, George R. Uhl, Ichiro Sora

  Oct. 2011, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 99(4) (4), 676 - 682, English, International magazine

  Scientific journal


• No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population

  Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Tsuyoshi Kitajima, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Christoph U. Correll, Nakao Iwata

  Oct. 2011, HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 26(7) (7), 445 - 450, English, International magazine

  Scientific journal


• Animal models of attention-deficit/hyperactivity disorder

  Yosefu Arime, Yumiko Kubo, Ichiro Sora

  Sep. 2011, Biological and Pharmaceutical Bulletin, 34(9) (9), 1373 - 1376, English, Domestic magazine

  Scientific journal


• Lack of association between translin-associated factor X gene (TSNAX) and methamphetamine dependence in the Japanese population

  Taro Kishi, Tomo Okochi, Tsuyoshi Kitajima, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Christoph U. Correll, Nakao Iwata

  Aug. 2011, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 35(7) (7), 1618 - 1622, English, International magazine

  Scientific journal


• Four mood stabilizers commonly induce FEZ1 expression in human astrocytes

  Zhiqian Yu, Chiaki Ono, Helen B. Kim, Hiroshi Komatsu, Yoichiro Tanabe, Nobutaka Sakae, Keiichi I. Nakayama, Hiroo Matsuoka, Ichiro Sora, William E. Bunney, Hiroaki Tomita

  Aug. 2011, BIPOLAR DISORDERS, 13(5-6) (5-6), 486 - 499, English, International magazine

  Scientific journal


• Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population

  Tomoko Yoshimura, Hinako Usui, Nagahide Takahashi, Akira Yoshimi, Shinichi Saito, Branko Aleksic, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Norio Ozaki

  Jul. 2011, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 35(5) (5), 1268 - 1272, English, International magazine

  Scientific journal


• 双極性障害治療薬のアストロサイトにおける発現プロファイルへの影響．

  兪志前, 小野千晶, 田邊陽一郎, 小松浩, 松岡洋夫, 曽良一郎, 富田博秋

  アルタ出版(株), May 2011, Bipolar Disorder研究会年会報, 9, 13 - 14, Japanese

  [Refereed]

  Scientific journal


• Effect of chronic lithium treatment on gene expression profile in mouse microglia and brain dendritic cells

  Zhiqian Yu, Chiaki Ono, Ichiro Sora, Hiroaki Tomita

  Apr. 2011, Japanese Journal of Neuropsychopharmacology, 31(2) (2), 101 - 102, English, Domestic magazine

  [Refereed]

  Scientific journal


• (-)-Pentazocine induces visceral chemical antinociception, but not thermal, mechanical, or somatic chemical antinociception, in mu-opioid receptor knockout mice

  Soichiro Ide, Masabumi Minami, George R. Uhl, Masamichi Satoh, Ichiro Sora, Kazutaka Ikeda

  Apr. 2011, MOLECULAR PAIN, 7, 23 - 23, English, International magazine

  Scientific journal


• Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese

  T. Okochi, T. Kishi, M. Ikeda, T. Kitajima, Y. Kinoshita, K. Kawashima, T. Okumura, T. Tsunoka, Y. Fukuo, T. Inada, M. Yamada, N. Uchimura, M. Iyo, I. Sora, N. Ozaki, H. Ujike, N. Iwata

  Mar. 2011, CURRENT NEUROPHARMACOLOGY, 9(1) (1), 151 - 154, English, International magazine

  Scientific journal


• Association Between 5HT1b Receptor Gene and Methamphetamine Dependence

  H. Ujike, M. Kishimoto, Y. Okahisa, M. Kodama, M. Takaki, T. Inada, N. Uchimura, M. Yamada, N. Iwata, M. Iyo, I. Sora, N. Ozaki

  Mar. 2011, CURRENT NEUROPHARMACOLOGY, 9(1) (1), 163 - 168, English, International magazine

  Scientific journal


• Association Study of Serine Racemase Gene with Methamphetamine Psychosis

  E. Yokobayashi, H. Ujike, T. Kotaka, Y. Okahisa, M. Takaki, M. Kodama, T. Inada, N. Uchimura, M. Yamada, N. Iwata, M. Iyo, I. Sora, N. Ozaki, S. Kuroda

  Mar. 2011, CURRENT NEUROPHARMACOLOGY, 9(1) (1), 169 - 175, English, International magazine

  Scientific journal


• Association Study of Two Cannabinoid Receptor Genes, CNR1 and CNR2, with Methamphetamine Dependence

  Y. Okahisa, M. Kodama, M. Takaki, T. Inada, N. Uchimura, M. Yamada, N. Iwata, M. Iyo, I. Sora, N. Ozaki, H. Ujike

  Mar. 2011, CURRENT NEUROPHARMACOLOGY, 9(1) (1), 183 - 189, English, International magazine

  Scientific journal


• Association between the Regulator of G-protein Signaling 9 Gene and Patients with Methamphetamine Use Disorder and Schizophrenia

  Y. Okahisa, M. Kodama, M. Takaki, T. Inada, N. Uchimura, M. Yamada, N. Iwata, M. Iyo, I. Sora, N. Ozaki, H. Ujike

  Mar. 2011, CURRENT NEUROPHARMACOLOGY, 9(1) (1), 190 - 194, English, International magazine

  Scientific journal


• MOP Reduction During Long-Term Methamphetamine Withdrawal was Restored by Chronic Post-Treatment with Fluoxetine

  H. Yamamoto, Y. Takamatsu, K. Imai, E. Kamegaya, Y. Hagino, M. Watanabe, T. Yamamoto, I. Sora, H. Koga, K. Ikeda

  Mar. 2011, CURRENT NEUROPHARMACOLOGY, 9(1) (1), 73 - 78, English, International magazine

  Scientific journal


• Effects of MDMA on Extracellular Dopamine and Serotonin Levels in Mice Lacking Dopamine and/or Serotonin Transporters

  Y. Hagino, Y. Takamatsu, H. Yamamoto, T. Iwamura, D. L. Murphy, G. R. Uhl, I. Sora, K. Ikeda

  Mar. 2011, CURRENT NEUROPHARMACOLOGY, 9(1) (1), 91 - 95, English, International magazine

  Scientific journal


• Effect of chronic lithium treatment on gene expression profile in mouse microglia and brain dendritic cells

  Zhiqian Yu, Chiaki Ono, Yoichiro Tanabe, Ichiro Sora, Hiroaki Tomita

  2011, NEUROSCIENCE RESEARCH, 71(2) (2), E122 - E122, English


• Serotonin 6 receptor gene is associated with methamphetamine-induced psychosis in a Japanese population

  Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Tsuyoshi Kitajima, Kunihiro Kawashima, Hiroshi Naitoh, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

  Jan. 2011, DRUG AND ALCOHOL DEPENDENCE, 113(1) (1), 1 - 7, English, International magazine

  Scientific journal


• 動物モデルを用いた喘息病態と治療法開発 精神的ストレス誘発性喘息の病態とμ-オピオイド受容体の関与

  奥山 香織, 河野 資, 大河原 雄一, 曽良 一郎, 櫻田 忍, 高柳 元明, 大野 勲

  (一社)日本アレルギー学会, Oct. 2010, アレルギー, 59(9-10) (9-10), 1353 - 1353, Japanese


• Antidepressant-Like Effect of Venlafaxine Is Abolished in mu-Opioid Receptor-Knockout Mice

  Soichiro Ide, Shunsuke Fujiwara, Masayuki Fujiwara, Ichiro Sora, Kazutaka Ikeda, Masabumi Minami, George R. Uhl, Kumatoshi Ishihara

  Sep. 2010, JOURNAL OF PHARMACOLOGICAL SCIENCES, 114(1) (1), 107 - 110, English, Domestic magazine

  Scientific journal


• PROKR2 is associated with methamphetamine dependence in the Japanese population

  Taro Kishi, Tsuyoshi Kitajima, Tomoko Tsunoka, Takenori Okumura, Tomo Okochi, Kunihiro Kawashima, Toshiya Inada, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

  Aug. 2010, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 34(6) (6), 1033 - 1036, English, International magazine

  Scientific journal


• The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population

  Hideaki Kobayashi, Hiroshi Ujike, Nakao Iwata, Toshiya Inada, Mitsuhiko Yamada, Yoshimoto Sekine, Naohisa Uchimura, Masaomi Iyo, Norio Ozaki, Masanari Itokawa, Ichiro Sora

  Aug. 2010, BEHAVIORAL AND BRAIN FUNCTIONS, 6, 50 - 50, English, International magazine

  Scientific journal


• 気分安定薬バルプロ酸およびラモトリギン投与によるヒト脳細胞遺伝子発現変化のマイクロアレイ解析による包括的検討

  田邊 陽一郎, 田中 千晶, 兪 志前, 小松 浩, 木村 好, 羽藤 愛, 松岡 洋夫, 曽良 一郎, 富田 博秋

  ニューロン由来のヒト神経細胞由来SK-N-SH細胞と、アストロサイト由来のU-87MG細胞、オリゴデンドロサイト由来のOL細胞を用いて、バルプロ酸とラモトリギン投与による脳細胞遺伝子発現変化を解析した。その結果、バルプロ酸はヒストン脱アセチル化酵素の遺伝子発現を抑制し、ラモトリギンは脳由来神経栄養因子や血管内皮増殖因子の遺伝子発現を促進することが確認された。

  アルタ出版(株), Jun. 2010, Bipolar Disorder, 8, 61 - 69, Japanese


• Enhanced carbonyl stress in a subpopulation of schizophrenia.

  Makoto Arai, Hiroko Yuzawa, Izumi Nohara, Tetsuo Ohnishi, Nanako Obata, Yoshimi Iwayama, Seiichi Haga, Tomoko Toyota, Hiroshi Ujike, Mayumi Arai, Tomoe Ichikawa, Atsushi Nishida, Yoko Tanaka, Aizo Furukawa, Yuuzou Aikawa, Osamu Kuroda, Kazuhiro Niizato, Ryosuke Izawa, Kazuhiko Nakamura, Norio Mori, Daisuke Matsuzawa, Kenji Hashimoto, Masaomi Iyo, Ichiro Sora, Masaaki Matsushita, Yuji Okazaki, Takeo Yoshikawa, Toshio Miyata, Masanari Itokawa

  CONTEXT: Various factors are involved in the pathogenesis of schizophrenia. Accumulation of advanced glycation end products, including pentosidine, results from carbonyl stress, a state featuring an increase in reactive carbonyl compounds (RCOs) and their attendant protein modifications. Vitamin B(6) is known to detoxify RCOs, including advanced glycation end products. Glyoxalase I (GLO1) is one of the enzymes required for the cellular detoxification of RCOs. OBJECTIVES: To examine whether plasma levels of pentosidine and serum vitamin B(6) are altered in patients with schizophrenia and to evaluate the functionality of GLO1 variations linked to concomitant carbonyl stress. DESIGN: An observational biochemical and genetic analysis study. SETTING: Multiple centers in Japan. PARTICIPANTS: One hundred six individuals (45 schizophrenic patients and 61 control subjects) were recruited for biochemical measurements. Deep resequencing of GLO1 derived from peripheral blood or postmortem brain tissue was performed in 1761 patients with schizophrenia and 1921 control subjects. MAIN OUTCOME MEASURES: Pentosidine and vitamin B(6) concentrations were determined by high-performance liquid chromatographic assay. Protein expression and enzymatic activity were quantified in red blood cells and lymphoblastoid cells using Western blot and spectrophotometric techniques. RESULTS: We found that a subpopulation of individuals with schizophrenia exhibit high plasma pentosidine and low serum pyridoxal (vitamin B(6)) levels. We also detected genetic and functional alterations in GLO1. Marked reductions in enzymatic activity were associated with pentosidine accumulation and vitamin B(6) depletion, except in some healthy subjects. Most patients with schizophrenia who carried the genetic defects exhibited high pentosidine and low vitamin B(6) levels in contrast with control subjects with the genetic defects, suggesting the existence of compensatory mechanisms. CONCLUSIONS: Our findings suggest that GLO1 deficits and carbonyl stress are linked to the development of a certain subtype of schizophrenia. Elevated plasma pentosidine and concomitant low vitamin B(6) levels could be the most cogent and easily measurable biomarkers in schizophrenia and should be helpful for classifying heterogeneous types of schizophrenia on the basis of their biological causes.

  Jun. 2010, Archives of general psychiatry, 67(6) (6), 589 - 97, English, International magazine

  Scientific journal


• MCCB日本語版の妥当性・信頼性の検討

  曽良一郎, 佐藤拓, 東海林渉, 宮澤志保, 住吉チカ, 住吉太幹, 兼田康宏, 上埜高志

  May 2010, 厚生労働科学研究費補助金（こころの健康科学研究事業）「統合失調症における社会生活機能障害の評価・支援－MATRICS-CCB日本語版による認知機能障害の評価と治療計画への応用－平成21年度総括・分担研究報告書（研究代表者：曽良一郎）, 5 - 15, Japanese

  Research society


• Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population

  Tomoko Tsunoka, Taro Kishi, Tsuyoshi Kitajima, Tomo Okochi, Takenori Okumura, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Hiroshi Naitoh, Toshiya Inada, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

  May 2010, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 34(4) (4), 639 - 644, English, International magazine

  Scientific journal


• Progesterone reduces hyperactivity of female and male dopamine transporter knockout mice

  Cheryl A. Frye, Ichiro Sora

  May 2010, BEHAVIOURAL BRAIN RESEARCH, 209(1) (1), 59 - 65, English, International magazine

  Scientific journal


• Impaired spatial working memory and decreased frontal cortex BDNF protein level in dopamine transporter knockout mice

  BingJin Li, Yosefu Arime, F. Scott Hall, George R. Uhl, Ichiro Sora

  Last, Feb. 2010, EUROPEAN JOURNAL OF PHARMACOLOGY, 628(1-3) (1-3), 104 - 107, English, International magazine, Co-authored internationally

  Scientific journal


• Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients

  Taro Kishi, Tomoko Tsunoka, Masashi Ikeda, Tsuyoshi Kitajima, Kunihiro Kawashima, Tomo Okochi, Takenori Okumura, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

  Feb. 2010, NEUROPHARMACOLOGY, 58(2) (2), 452 - 456, English, International magazine

  Scientific journal


• The role of FABPs in postnatal hippocampal neurogenesis and function

  Miho Matsumata, Motoko Maekawa, Yosefu Arime, Yuji Owada, Ichiro Sora, Takeo Yoshikawa, Noriko Osumi

  2010, NEUROSCIENCE RESEARCH, 68, E171 - E171, English


• Prefrontal Norepinephrine Transporter Blockade Ameliorates Deficits of Prepulse Inhibition in Dopamine Transporter Knockout Mice via Cortico-subcortical Glutamate Projections

  Y. Arime, S. Hall, G. Uhl, I. Sora

  2010, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 13, 59 - 59, English


• Effect of chronic lithium treatment on gene expression profile in mouse microglia and brain dendritic cells

  Z. Yu, C. Ono, Y. Tanabe, I. Sora, H. Tomita

  2010, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 13, 133 - 134, English


• Mood stabilizers-mediated gene expression in human astrocytes

  Zhiqian Yu, Chiaki Ono, Yoichiro Tanabe, Ichiro Sora, Hiroaki Tomita

  2010, NEUROSCIENCE RESEARCH, 68, E317 - E317, English


• Combination of cell culture assays and knockout mouse analyses for the study of opioid partial agonism.

  Ide S, Minami M, Sora I, Ikeda K

  Nonselective opioid partial agonists, such as buprenorphine, butorphanol, and pentazocine, have been widely used as analgesics and for anti-addiction therapy. However, the precise molecular mechanisms underlying the therapeutic and rewarding effects of these drugs have not been clearly delineated. Recent success in developing mu-opioid receptor knockout (MOP-KO) mice has elucidated the molecular mechanisms underlying the effects of morphine and other opioids. We have revealed the in vivo roles of MOPs in the effects of opioid partial agonists by using MOP-KO mice for behavioral tests (e.g., several kinds of antinociceptive tests for analgesic effects, conditioned place preference test for dependence). The combination of the cell culture assays using cDNA for mu, delta, and kappa opioid receptors and the behavioral tests using MOP-KO mice has provided novel theories on the molecular mechanisms underlying the effects of opioid ligands, especially opioid partial agonists.

  2010, Methods in molecular biology (Clifton, N.J.), 617, 363 - 374, English, International magazine

  [Refereed]

  Scientific journal


• Transgenic mice in the study of drug addiction and the effects of psychostimulant drugs

  Ichiro Sora, BingJin Li, Moe Igari, F. Scott Hall, Kazutaka Ikeda

  2010, ADDICTION REVIEWS 2, 1187, 218 - 246, English, International magazine, Co-authored internationally

  Scientific journal


• The Involvement of mu-Opioid Receptors in the Central Nervous System in the Worsening of Allergic Airway Inflammation by Psychological Stress in Mice

  Kaori Okuyama, Kana Wada, Shinobu Sakurada, Hirokazu Mizoguchi, Hiroshi Komatsu, Ichiro Sora, Gen Tamura, Yuichi Ohkawara, Motoaki Takayanagi, Isao Ohno

  2010, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 152(4) (4), 342 - 352, English, International magazine

  Scientific journal


• Reduced emotional and corticosterone responses to stress in mu-opioid receptor knockout mice

  Soichiro Ide, Ichiro Sora, Kazutaka Ikeda, Masabumi Minami, George R. Uhl, Kumatoshi Ishihara

  Jan. 2010, NEUROPHARMACOLOGY, 58(1) (1), 241 - 247, English, International magazine

  Scientific journal


• Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery

  Kenichi Fukuda, Masakazu Hayashida, Soichiro Ide, Naoko Saita, Yoshihiko Kokita, Shinya Kasai, Daisuke Nishizawa, Yasukazu Ogai, Junko Hasegawa, Makoto Nagashima, Megumi Tagami, Hiroshi Komatsu, Ichiro Sora, Hisashi Koga, Yuzuru Kaneko, Kazutaka Ikeda

  Dec. 2009, PAIN, 147(1-3) (1-3), 194 - 201, English, International magazine

  Scientific journal


• Deletion of mu-opioid receptor in mice does not affect the minimum alveolar concentration of volatile anaesthetics and nitrous oxide-induced analgesia

  T. Koyama, T. Mayahara, T. Wakamatsu, I. Sora, K. Fukuda

  Nov. 2009, BRITISH JOURNAL OF ANAESTHESIA, 103(5) (5), 744 - 749, English, International magazine

  Scientific journal


• カルボニルストレス性統合失調症の病態に関する研究

  新井 誠, 湯澤 公子, 小幡 菜々子, 野原 泉, 新井 麻友美, 市川 智恵, 豊田 倫子, 大西 哲生, 氏家 寛, 曽良 一郎, 岡崎 祐士, 吉川 武男, 宮田 敏男, 糸川 昌成

  (公社)日本生化学会, Sep. 2009, 日本生化学会大会プログラム・講演要旨集, 82回, 4P - 550, Japanese


• 気管支喘息 病態生理 精神的ストレス誘発性喘息におけるグルココルチコイド受容体およびμ-オピオイド受容体の関与

  奥山 香織, 和田 佳奈, 河野 資, 大河原 雄一, 田村 弦, 曽良 一郎, 高柳 元明, 大野 勲

  (一社)日本アレルギー学会, Sep. 2009, アレルギー, 58(8-9) (8-9), 1295 - 1295, Japanese


• Stress and methylphenidate treatment, both modulate neuronal activity in an animal model for ADHD

  A. G. Schmitt, F. S. Hall, M. Perona, G. Ortega, M. Hofmann, Sora, I, G. R. Uhl, P. Riederer, K. P. Lesch, M. Gerlach, E. Gruenblatt

  Sep. 2009, PHARMACOPSYCHIATRY, 42(5) (5), 240 - 241, English


• Side effects of opioid and gene variants

  Ichiro Sora, Hiroshi Komatsu, Moe Igari, Soichiro Ide, Kazutaka Ikeda, Naoto Shimoyama

  Sep. 2009, Japanese Journal of Anesthesiology, 58(9) (9), 1109 - 1111, Japanese, Domestic magazine

  Scientific journal


• COCAINE-CONDITIONED LOCOMOTION IN DOPAMINE TRANSPORTER, NOREPINEPHRINE TRANSPORTER AND SEROTONIN TRANSPORTER KNOCKOUT MICE

  F. S. Hall, X. -F. Li, J. Randall-Thompson, I. Sora, D. L. Murphy, K. -P. Lesch, M. Caron, G. R. Uhl

  Sep. 2009, NEUROSCIENCE, 162(4) (4), 870 - 880, English, International magazine

  Scientific journal


• Association between KCNJ6 (GIRK2) Gene Polymorphisms and Postoperative Analgesic Requirements after Major Abdominal Surgery

  Daisuke Nishizawa, Makoto Nagashima, Ryoji Katoh, Yasuo Satoh, Megumi Tagami, Shinya Kasai, Yasukazu Ogai, Wenhua Han, Junko Hasegawa, Naohito Shimoyama, Ichiro Sora, Masakazu Hayashida, Kazutaka Ikeda

  Sep. 2009, PLOS ONE, 4(9) (9), e7060, English, International magazine

  Scientific journal


• G72 gene is associated with susceptibility to methamphetamine psychosis

  Tatsuya Kotaka, Hiroshi Ujike, Yuko Okahisa, Manabu Takaki, Kenji Nakata, Masafumi Kodama, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Shigetoshi Kuroda

  Aug. 2009, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 33(6) (6), 1046 - 1049, English, International magazine

  Scientific journal


• A functional polymorphism in estrogen receptor alpha gene is associated with Japanese methamphetamine induced psychosis

  Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Tomo Okochi, Tomoko Tsunoka, Takenori Okumura, Toshiya Inada, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

  Aug. 2009, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 33(5) (5), 895 - 898, English, International magazine

  Scientific journal


• Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population

  Tomo Okochi, Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoko Kinoshita, Kunihiro Kawashima, Takenori Okumura, Tomoko Tsunoka, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Hiroshi Ujike, Nakao Iwata

  Aug. 2009, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 33(5) (5), 903 - 905, English, International magazine

  Scientific journal


• Neurobsychopharmacological effects of methylphenidate

  Kazutaka Ikeda, Yukio Takamatsu, Yoko Hagino, Ichiro Sora

  Jun. 2009, Japanese Journal of Neuropsychopharmacology, 29(3) (3), 121 - 123, Japanese


• Genetic variants of D2 but not D3 or D4 dopamine receptor gene are associated with rapid onset and poor prognosis of methamphetamine psychosis

  Hiroshi Ujike, Takeshi Katsu, Yuko Okahisa, Manabu Takaki, Masafumi Kodama, Toshiya Inada, Naohisa Uchimura, Mitsuhiko Yamada, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Shigetoshi Kuroda

  Jun. 2009, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 33(4) (4), 625 - 629, English, International magazine

  Scientific journal


• An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis

  Kazuhiko Nakamura, Yoshimoto Sekine, Noriyoshi Takei, Yasuhide Iwata, Katsuaki Suzuki, Ayyappan Anitha, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Nakao Iwata, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Hiroshi Ujike, Norio Mori

  May 2009, NEUROSCIENCE LETTERS, 455(2) (2), 120 - 123, English, International magazine

  Scientific journal


• Depletion of Serotonin and Selective Inhibition of 2B Receptor Suppressed Tumor Angiogenesis by Inhibiting Endothelial Nitric Oxide Synthase and Extracellular Signal-Regulated Kinase 1/2 Phosphorylation

  Masanori Asada, Satoru Ebihara, Shinsuke Yamanda, Kaijun Niu, Tatsuma Okazaki, Ichiro Sora, Hiroyuki Arai

  Apr. 2009, NEOPLASIA, 11(4) (4), 408 - U117, English, International magazine

  Scientific journal


• 稀な遺伝子変異をもつ症例を出発点とした統合失調症感受性遺伝子の同定

  新井 誠, 湯澤 公子, 野原 泉, 小幡 菜々子, 大西 哲生, 豊田 倫子, 羽賀 誠一, 曽良 一郎, 氏家 寛, 松下 正明, 岡崎 祐士, 吉川 武男, 宮田 敏男, 糸川 昌成

  (公財)先進医薬研究振興財団, Mar. 2009, 精神薬療研究年報, (41) (41), 95 - 96, Japanese


• mu-Opioid receptor-independent fashion of the suppression of sodium currents by mu-opioid analgesics in thalamic neurons

  Keisuke Hashimoto, Taku Amano, Akiko Kasakura, George R. Uhl, Ichiro Sora, Norio Sakai, Naoko Kuzumaki, Tsutomu Suzuki, Minoru Narita

  Mar. 2009, NEUROSCIENCE LETTERS, 453(1) (1), 62 - 67, English, International magazine

  Scientific journal


• Association Study Between the PIK4CA Gene and Methamphetamine Use Disorder in a Japanese Population

  Nobuhisa Kanahara, Ryosuke Miyatake, Yoshimoto Sekine, Toshiya Inada, Norio Ozaki, Nakao Iwata, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Ichiro Sora, Hiroshi Ujike, Masaomi Iyo, Kenji Hashimoto

  Mar. 2009, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 150B(2) (2), 233 - 238, English, International magazine

  Scientific journal


• Prefrontal NET blockade ameliorates prepulse inhibition deficits in dopamine transporter knockout mice

  Yosefu Arime, Yoshiyuki Kasahara, Ichiro Sora

  2009, NEUROSCIENCE RESEARCH, 65, S252 - S252, English


• D5 dopamine receptor is involved in the functional modification of dopamine transporter

  Seiji Hayashizaki, Shinobu Hirai, Yumi Ito, Yoshiko Honda, Yosefu Arime, Ichiro Sora, Tohru Kodama, Haruo Okado, Masahiko Takada

  2009, NEUROSCIENCE RESEARCH, 65, S256 - S256, English


• MONOAMINE TRANSPORTER AS A TARGET MOLECULE FOR PSYCHOSTIMULANTS

  Ichiro Sora, BingJin Li, Setsu Fumushima, Asami Fukui, Yosefu Arime, Yoshiyuki Kasahara, Hiroaki Tomita, Kazutaka Ikeda

  2009, ADVANCES IN NEUROPHARMACOLOGY, 85, 29 - 33, English, International magazine, Co-authored internationally

  Scientific journal


• Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence

  Yuko Okahisa, Hiroshi Ujike, Tatsuya Kotaka, Yukitaka Morita, Masafumi Kodama, Toshiya Inada, Mitsuhiko Yamada, Nakao Iwata, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Shigetoshi Kuroda

  2009, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 63(3) (3), 417 - 422, English, International magazine

  Scientific journal


• Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype

  Masakazu Hayashida, Makoto Nagashima, Yasuo Satoh, Ryoji Katoh, Megumi Tagami, Soichiro Ide, Shinya Kasai, Daisuke Nishizawa, Yasukazu Ogai, Junko Hasegawa, Hiroshi Komatsu, Ichiro Sora, Kenichi Fukuda, Hisashi Koga, Kazuo Hanaoka, Kazutaka Ikeda

  Nov. 2008, PHARMACOGENOMICS, 9(11) (11), 1605 - 1616, English, International magazine

  Scientific journal


• Association Study Between Polymorphisms in Glutathione-Related Genes and Methamphetamine Use Disorder in a Japanese Population

  Tasuku Hashimoto, Kenji Hashimoto, Ryosuke Miyatake, Daisuke Matsuzawa, Yoshimoto Sekine, Toshiya Inada, Norio Ozaki, Nakao Iwata, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Ichiro Sora, Hiroshi Ujike, Masaomi Iyo

  Oct. 2008, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 147B(7) (7), 1040 - 1046, English, International magazine

  Scientific journal


• Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions

  Maria T. G. Perona, Shonna Waters, Frank Scott Hall, Ichiro Sora, Klaus-Peter Lesch, Dennis L. Murphy, Marc Caron, George R. Uhl

  Sep. 2008, BEHAVIOURAL PHARMACOLOGY, 19(5-6) (5-6), 566 - 574, English, International magazine

  Scientific journal


• Reduced tumor growth in a mouse model of schizophrenia, lacking the dopamine transporter

  Masanori Asada, Satoru Ebihara, Yohtaro Numachi, Tatsuma Okazaki, Shinsuke Yamanda, Kazutaka Ikeda, Hiroyasu Yasuda, Ichiro Sora, Hiroyuki Arai

  Aug. 2008, INTERNATIONAL JOURNAL OF CANCER, 123(3) (3), 511 - 518, English, International magazine

  Scientific journal


• The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population

  Makiko Kishimoto, Hiroshi Ujike, Yuko Okahisa, Tatsuya Kotaka, Manabu Takaki, Masafumi Kodama, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Shigetoshi Kuroda

  Aug. 2008, BEHAVIORAL AND BRAIN FUNCTIONS, 4, 37 - 37, English, International magazine

  Scientific journal


• Methylphenidate and stress exert influences on synaptic protein expression in a mouse model for attention-deficit/hyperactivity disorder

  E. Gruenblatt, S. F. Hall, M. Kreutzfeldt, M. T. Perona, S. Nietzer, I. Sora, G. R. Uhl, R. Riederer, K. -P. Lesch, M. Gerlach, A. G. Schmitt

  Jul. 2008, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 11, 232 - 232, English


• Hyperthermic and lethal effects of methamphetamine: Roles of dopamine D1 and D2 receptors

  Miki Ito, Yohtaro Numachi, Arihisa Ohara, Ichiro Sora

  Jun. 2008, NEUROSCIENCE LETTERS, 438(3) (3), 327 - 329, English, International magazine

  Scientific journal


• Dopamine D1 receptor-induced signaling through TrkB receptors in striatal neurons

  Yuriko Iwakura, Hiroyuki Nawa, Ichiro Sora, Moses V. Chao

  Jun. 2008, JOURNAL OF BIOLOGICAL CHEMISTRY, 283(23) (23), 15799 - 15806, English, International magazine

  Scientific journal


• Abolished thermal and mechanical antinociception but retained visceral chemical antinociception induced by butorphanol in mu-opioid receptor knockout mice

  Soichiro Ide, Masabumi Minami, Kumatoshi Ishihara, George R. Uhl, Masamichi Satoh, Ichiro Sora, Kazutaka Ikeda

  Jun. 2008, NEUROPHARMACOLOGY, 54(8) (8), 1182 - 1188, English, International magazine

  Scientific journal


• ストレス誘発性喘息の機序 μ-オピオイド受容体を介した制御性T細胞誘導の抑制

  奥山 香織, 和田 佳奈, 櫻田 忍, 曽良 一郎, 高柳 元明, 大野 勲

  (一社)日本呼吸器学会, May 2008, 日本呼吸器学会雑誌, 46(増刊) (増刊), 231 - 231, Japanese


• Genome-wide association for methamphetamine dependence

  George R. Uhl, Tomas Drgon, Qing-Rong Liu, Catherine Johnson, Donna Walther, Tokutaro Komiyama, Mutsuo Harano, Yoshimoto Sekine, Toshiya Inada, Norio Ozaki, Masaomi Iyo, Nakao Iwata, Mitsuhiko Yamada, Ichiro Sora, Chih-Ken Chen, Hsing-Cheng Liu, Hiroshi Ujike, Shih-Ku Lin

  Mar. 2008, ARCHIVES OF GENERAL PSYCHIATRY, 65(3) (3), 345 - 355, English, Co-authored internationally

  [Refereed]

  Scientific journal


• Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence

  Kyohei Otani, Hiroshi Ujike, Ayumu Sakai, Yuko Okahisa, Tatsuya Kotaka, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Shigetoshi Kuroda

  Mar. 2008, NEUROSCIENCE LETTERS, 434(1) (1), 88 - 92, English, International magazine

  Scientific journal


• [Drug dependence and methylphenidate].

  Ichiro Sora, Moe Ikari, Kazutaka Ikeda

  2008, Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 110(10) (10), 941 - 5, Japanese, Domestic magazine

  Scientific journal


• Association Study between Casein Kinase 1 Epsilon Gene and Methamphetamine Dependence

  T. Kotaka, H. Ujike, Y. Morita, M. Kishimoto, Y. Okahisa, T. Inada, M. Harano, T. Komiyama, T. Hori, M. Yamada, Y. Sekine, N. Iwata, M. Iyo, I. Sora, N. Ozaki, S. Kuroda

  2008, DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES, 1139, 43 - 48, English, International magazine

  [Refereed]

  Scientific journal


• Short Allele of 5-HTTLPR as a Risk Factor for the Development of Psychosis in Japanese Methamphetamine Abusers

  Norikazu Ezaki, Kazuhiko Nakamura, Yoshimoto Sekine, Ismail Thanseem, Ayyappan Anitha, Yasuhide Iwata, Masayoshi Kawai, Kiyokazu Takebayashi, Katsuaki Suzuki, Nori Takei, Masaomi Iyo, Toshiya Inada, Nakao Iwata, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Ichiro Sora, Hiroshi Ujike, Norio Mori

  2008, DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES, 1139, 49 - 56, English, International magazine

  Scientific journal


• Association Study of the Calcineurin A Gamma Subunit Gene (PPP3CC) and Methamphetamine-Use Disorder in a Japanese Population A Collaborative Study by the Japanese Genetics Initiative for Drug Abuse

  Y. Kinoshita, M. Ikeda, H. Ujike, T. Kitajima, Y. Yamanouchi, B. Aleksic, T. Kishi, K. Kawashima, T. Ohkouchi, N. Ozaki, T. Inada, M. Harano, T. Komiyama, T. Hori, M. Yamada, Y. Sekine, M. Iyo, I. Sora, N. Iwata

  2008, DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES, 1139, 57 - 62, English, International magazine

  Scientific journal


• Prostate Apoptosis Response 4 Gene Is Not Associated with Methamphetamine-Use Disorder in the Japanese Population

  Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Masaomi Iyo, Ichiro Sora, Yoshimoto Sekine, Norio Ozaki, Hiroshi Ujike, Nakao Iwata

  2008, DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES, 1139, 83 - 88, English, International magazine

  Scientific journal


• Glutamate Cysteine Ligase Modifier (GCLM) Subunit Gene Is Not Associated with Methamphetamine-Use Disorder or Schizophrenia in the Japanese Population

  Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Horie, Mitsuhiko Yamada, Masaomi Iyo, Ichiro Sora, Yoshimoto Sekine, Norio Ozaki, Hiroshi Ujike, Nakao Iwata

  2008, DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES, 1139, 63 - 69, English, International magazine

  Scientific journal


• Alpha4 and Beta2 Subunits of Neuronal Nicotinic Acetylcholine Receptor Genes Are Not Associated with Methamphetamine-Use Disorder in the Japanese Population

  Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Masaomi Iyo, Ichiro Sora, Yoshimoto Sekine, Norio Ozaki, Hiroshi Ujike, Nakao Iwata

  2008, DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES, 1139, 70 - 82, English, International magazine

  Scientific journal


• The dysbindin gene (DTNBP1) is associated with methamphetamine psychosis

  Makiko Kishimoto, Hiroshi Ujike, Yasuko Motohashi, Yuji Tanaka, Yuko Kahisa, Tatsuya Kotaka, Mutsuo Harano, Toshiya Inada, Mitsuhiko Yamada, Tokutaro Komiyama, Toru Hori, Yoshimoto Sekine, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Shigetoshi Kuroda

  Jan. 2008, BIOLOGICAL PSYCHIATRY, 63(2) (2), 191 - 196, English, International magazine

  Scientific journal


• Lack of association between polymorphisms in the 5 ' upstream region of the DISC1 gene and mood disorders

  Makoto Arai, Nanako Obata, Thessa T. J. P. Kockelkorn, Kazuo Yamada, Tomoko Toyota, Seiichi Haga, Yuuki Yoshida, Hiroshi Ujike, Ichiro Sora, Kazuhiko Ikeda, Takeo Yoshikawa, Masanari Itokawa

  Dec. 2007, PSYCHIATRIC GENETICS, 17(6) (6), 357 - 357, English, International magazine


• Methamphetamine-induced hyperthermia and lethal toxicity: Role of the dopamine and serotonin transporters

  Yohtaro Numachi, Arihisa Ohara, Motoyasu Yamashita, Setsu Fukushima, Hideaki Kobayashi, Harurmi Hata, Hidekazu Watanabe, F. Scott Hall, Klaus-Peter Lesch, Dennis L. Murphy, George R. Uhl, Ichiro Sora

  Last, Oct. 2007, EUROPEAN JOURNAL OF PHARMACOLOGY, 572(2-3) (2-3), 120 - 128, English, International magazine, Co-authored internationally

  Scientific journal


• 精神的ストレスはμ-オピオイド受容体活性化を介し制御性T細胞の誘導を抑制することにより喘息を悪化させる

  奥山 香織, 和田 佳奈, 土橋 和久, 櫻田 忍, 曽良 一郎, 高柳 元明, 大野 勲

  (一社)日本アレルギー学会, Sep. 2007, アレルギー, 56(8-9) (8-9), 1078 - 1078, Japanese


• Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: Evidence of genotype specific sexual dimorphic epistasis

  Martin O. Job, Amanda Tang, F. Scott Hall, Ichiro Sora, George R. Uhl, Susan E. Bergeson, Rueben A. Gonzales

  Sep. 2007, BIOLOGICAL PSYCHIATRY, 62(6) (6), 627 - 634, English, International magazine

  Scientific journal


• Methamphetamine-induced locomotor activity and sensitization in dopamine transporter and vesicular monoamine transporter 2 double mutant mice

  Setsu Fukushima, Haowei Shen, Harumi Hata, Arihisa Ohara, Kayo Ohmi, Kazutaka Ikeda, Yohtaro Numachi, Hideaki Kobayashi, F. Scott Hall, George R. Uhl, Ichiro Sora

  Last, Jul. 2007, PSYCHOPHARMACOLOGY, 193(1) (1), 55 - 62, English, International magazine, Co-authored internationally

  Scientific journal


• Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis

  Daisuke Matsuzawa, Kenji Hashimoto, Ryosuke Miyatake, Yukihiko Shirayama, Eiji Shimizu, Kazuhisa Maeda, Yoichi Suzuki, Yoichi Mashimo, Yoshimoto Sekine, Toshiya Inada, Norio Ozaki, Nakao Iwata, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Ichiro Sora, Hiroshi Ujike, Akira Hata, Akira Sawa, Masaomi Iyo

  Jul. 2007, AMERICAN JOURNAL OF PSYCHIATRY, 164(7) (7), 1105 - 1114, English, International magazine

  Scientific journal


• Genetic deletion of vesicular monoamine transporter-2 (VMAT2) reduces dopamine transporter activity in mesencephalic neurons in primary culture

  Hideko Yamamoto, Etsuko Kamegaya, Yoko Hagino, Kazuhide Imai, Akihiro Fujikawa, Kohei Tamura, Tomoyuki Enokiya, Toshifumi Yamamoto, Takao Takeshima, Hisashi Koga, George R. Uhl, Kazutaka Ikeda, Ichiro Sora

  Jul. 2007, NEUROCHEMISTRY INTERNATIONAL, 51(2-4) (2-4), 237 - 244, English, International magazine

  Scientific journal


• Anxiety is strongly associated with low Qol in Japanese diabetic subjects

  Umiko Yoshida, Masashi Hirai, Susumu Suzuki, Shuichi Awata, Motoyasu Yamashita, Arihisa Ohara, Yoshinori Hinokio, Ichiro Sora, Hiroo Matsuoka, Yoshitomo Oka

  Jun. 2007, DIABETES, 56, A711 - A711, English


• 精神的ストレス誘発性喘息におけるμ-オピオイド受容体の関与

  奥山 香織, 梶川 聡子, 和田 佳奈, 田村 弦, 櫻田 忍, 曽良 一郎, 高柳 元明, 大野 勲

  (一社)日本アレルギー学会, Apr. 2007, アレルギー, 56(3-4) (3-4), 333 - 333, Japanese


• 精神的ストレスによる喘息増悪の機序解析 μ-オピオイド受容体を介した神経-免疫学的応答

  奥山 香織, 梶川 聡子, 和田 佳奈, 櫻田 忍, 曽良 一郎, 高柳 元明, 大野 勲

  (公社)日本薬学会, Mar. 2007, 日本薬学会年会要旨集, 127年会(2) (2), 138 - 138, Japanese


• 統合失調症の感覚情報制御障害の主観的知覚強度評価尺度を用いた研究

  山下元康, 福島攝, 有銘預世布, 伊藤文晃, 小原可久, 坂本修一, 中村真樹, 鈴木陽一, 松岡洋夫, 曽良一郎

  Last, Mar. 2007, 精神薬療研究年報, (39) (39), 94 - 103, Japanese

  [Invited]

  Scientific journal


• Methamphetamine alters expression of DNA methyltransferase 1 mRNA in rat brain

  Yohtaro Numachi, Haowey Shen, Sumiko Yoshida, Ko Fujiyama, Shigenobu Toda, Hiroo Matsuoka, Ichiro Sora, Mitsurnoto Sato

  Mar. 2007, NEUROSCIENCE LETTERS, 414(3) (3), 213 - 217, English, International magazine

  Scientific journal


• A resistance gene in disguise for schizophrenia?

  Nagafumi Doi, Masanari Itokawa, Yoko Hoshi, Makoto Arai, Aizou Furukawa, Hiroshi Ujike, Ichiro Sora, Takeo Yoshikawa

  Mar. 2007, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 144B(2) (2), 165 - 173, English, International magazine

  Scientific journal


• Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia

  M. Ikeda, N. Ozaki, T. Suzuki, T. Kitajima, Y. Yamanouchi, Y. Kinoshita, T. Kishi, Y. Sekine, M. Iyo, M. Harano, T. Komiyama, M. Yamada, I. Sora, H. Ujike, T. Inada, N. Iwata

  Feb. 2007, GENES BRAIN AND BEHAVIOR, 6(1) (1), 107 - 112, English, International magazine

  Scientific journal


• Involvement of mu-opioid receptors in the exacerbation of airway inflammation in a murine model of allergic asthma

  Kaori Okuyama, Yoshie Arai, Satoko Kajikawa, Maya Naruse, Gen Tamura, Shinobu Sakurada, Ichiro Sora, Motoaki Takayanagi, Isao Ohno

  2007, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 143, 110 - 110, English

  [Refereed]


• Monoamine transporter as a molecular target for drug abuse

  Ichiro Sora, Hideko Yamamoto, Kazutaka Ikeda

  2007, JOURNAL OF PHARMACOLOGICAL SCIENCES, 103, 39P - 39P, English


• The distinctive effects of acute and chronic psychological stress on airway inflammation in a murine model of allergic asthma

  Kaori Okuyama, Keiko Ohwada, Shinobu Sakurada, Naoko Sato, Ichiro Sora, Gen Tamura, Motoaki Takayanagi, Isao Ohno

  Japanese Society of Allergology, 2007, Allergology International, 56(1) (1), 29 - 35, English, International magazine

  Scientific journal


• Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons

  G. C. Harburg, F. S. Hall, A. V. Harrist, I. Sora, G. R. Uhl, A. J. Eisch

  Jan. 2007, NEUROSCIENCE, 144(1) (1), 77 - 87, English, International magazine

  Scientific journal


• The effects of DAT, SERT and NET gene knockout on behavior in animal models of depression

  Frank S. Hall, Maria T. Perona, Shonna Waters, Ichiro Sora, Klaus-Peter Lesch, Dennis L. Murphy, Marc Caron, George R. Uhl

  Dec. 2006, NEUROPSYCHOPHARMACOLOGY, 31, S155 - S156, English


• Identification of a risk haplotype of the alpha-synuclein gene in Japanese with sporadic Parkinson's disease

  Hideaki Kobayashi, Hiroshi Ujike, Junko Hasegawa, Mitsutoshi Yamamoto, Akihiro Kanzaki, Ichiro Sora

  Last, Dec. 2006, MOVEMENT DISORDERS, 21(12) (12), 2157 - 2164, English, International magazine

  Scientific journal


• Association study between the NrCAM gene and patients with methamphetamine use disorders

  Yuko Okahisa, Hiroshi Ujike, Yuji Tanaka, Kyohei Otani, Yukitaka Morita, Makiko Kishimoto, Akiko Morio, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Shigetoshi Kuroda

  Oct. 2006, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 141B(7) (7), 806 - 807, English


• The frizzled 3 (FZD3) gene is associated with methamphetamine psychosis

  Makiko Kishimoto, Hiroshi Ujike, Yuji Tanaka, Kyohei Otani, Yukitaka Morita, Akiko Morio, Yuko Okahisa, Tatsuya Kotaka, Mutsuo Harano, Toshiya Inada, Mitsuhiko Yamada, Tokutaro Komiyama, Toru Hori, Yoshimoto Sekine, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Shigetoshi Kuroda

  Oct. 2006, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 141B(7) (7), 807 - 807, English


• Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice

  Motoyasu Yamashita, Setsu Fukushima, Hao-wei Shen, F. Scott Hall, George R. Uhl, Yohtaro Numachi, Hideaki Kobayashi, Ichiro Sora

  Last, Oct. 2006, NEUROPSYCHOPHARMACOLOGY, 31(10) (10), 2132 - 2139, English, International magazine, Co-authored internationally

  Scientific journal


• Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder

  Nagisa Aoyama, Nagahide Takahashi, Kiyoyuki Kitaichi, Ryoko Ishihara, Shinichi Saito, Nobuhisa Maeno, Xiaofei Ji, Kenji Takagi, Yoshimoto Sekine, Masaomi Iyo, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Ichiro Sora, Hiroshi Ujike, Nakao Iwata, Toshiya Inada, Norio Ozaki

  Oct. 2006, ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 30(10) (10), 1644 - 1649, English, International magazine

  Scientific journal


• Correlation of tau gene polymorphism with age at onset of Parkinson's disease

  Hideaki Kobayashi, Hiroshi Ujike, Junko Hasegawa, Mitsutoshi Yamamoto, Akihiro Kanzaki, Ichiro Sora

  Last, Sep. 2006, NEUROSCIENCE LETTERS, 405(3) (3), 202 - 206, English, International magazine

  Scientific journal


• Mu opioid receptor-dependent and independent components in effects of tramadol

  Soichiro Ide, Masabumi Minami, Kumatoshi Ishihara, George R. Uhl, Ichiro Sora, Kazutaka Ikeda

  Sep. 2006, NEUROPHARMACOLOGY, 51(3) (3), 651 - 658, English, International magazine

  Scientific journal


• Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations

  Kazuhiko Nakamura, Chih-Ken Chen, Yoshimoto Sekine, Yasuhide Iwata, A. Anitha, El-Wui Loh, Nori Takei, Atsuko Suzuki, Masayoshi Kawai, Kiyokazu Takebayashi, Katsuaki Suzuki, Yoshio Minabe, Kenji Tsuchiya, Kazuo Yamada, Masaomi Iyo, Norio Ozaki, Toshiya Inada, Nakao Iwata, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Ichiro Sora, Hiroshi Ujike, David M. Ball, Takeo Yoshikawa, Shih-Ku Lin, Norio Mori

  Sep. 2006, HUMAN GENETICS, 120(2) (2), 243 - 252, English, International magazine

  Scientific journal


• An association study between catechol-O-methyl transferase gene polymorphism and methamphetamine psychotic disorder

  Atsuko Suzuki, Kazuhiko Nakamura, Yoshimoto Sekine, Yoshio Minabe, Nori Takei, Katsuaki Suzuki, Yasuhide Iwata, Masayoshi Kawai, Kiyokazu Takebayashi, Hideo Matsuzaki, Masaomi Iyo, Norio Ozaki, Tosihiya Inada, Nakao Iwata, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Ichiro Sora, Hiroshi Ujike, Norio Mori

  Aug. 2006, PSYCHIATRIC GENETICS, 16(4) (4), 133 - 138, English, International magazine

  Scientific journal


• Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder

  Nagisa Aoyama, Kiyoyuki Kitaichi, Nagahide Takahashi, Shinichi Saito, Nobuhisa Maemo, Nakao Iwata, Hiroshi Ujike, Mutsuo Harano, Ichiro Sora, Masaomi Iyo, Tokutaro Komiyama, Mitsuhiko Yamada, Yoshimoto Sekine, Toshiya Inada, Norio Ozaki

  Jul. 2006, INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 21(4) (4), A32 - A32, English

  [Refereed]

  Scientific journal


• Association study between cytochrome P450 2D6 genotype and patients with methamphetamine dependence

  Kyohei Otani, Hiroshi Ujike, Ayumu Sakai, Yuji Tanaka, Naohiko Uchida, Akira Nomura, Yukitaka Morita, Makiko Kishimoto, Akiko Morio, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Shigetoshi Kuroda

  Jul. 2006, INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 21(4) (4), A31 - A32, English

  [Refereed]

  Scientific journal


• Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis

  Hideaki Kobayashi, Harumi Hata, Hiroshi Ujike, Mutsuo Harano, Toshiya Inada, Tokutaro Komiyama, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Norio Ozaki, Masanari Itokawa, Maki Naka, Soichiro Ide, Kazutaka Ikeda, Yohtaro Numachi, Ichiro Sora

  Last, Jul. 2006, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 141B(5) (5), 482 - 486, English, International magazine

  Scientific journal


• Intracisternal A-particle element in the 3 ' noncoding region of the mu-opioid receptor gene in CXBK mice: a new genetic mechanism underlying differences in opioid sensitivity

  Wenhua Han, Shinya Kasai, Harumi Hata, Takehiro Takahashi, Yukio Takamatsu, Hideko Yamamoto, George R. Uhl, Ichiro Sora, Kazutaka Ikeda

  Jun. 2006, PHARMACOGENETICS AND GENOMICS, 16(6) (6), 451 - 460, English, International magazine

  Scientific journal


• Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence

  Akira Nomura, Hiroshi Ujike, Yuji Tanaka, Kyohei Otani, Yukitaka Morita, Makiko Kishimoto, Akiko Morio, Mutsuo Harano, Toshiya Inada, Mitsuhiko Yamada, Tokutaro Komiyama, Yoshimoto Sekine, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Shigetoshi Kuroda

  May 2006, NEUROSCIENCE LETTERS, 400(1-2) (1-2), 158 - 162, English, International magazine

  Scientific journal


• Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms

  S. Ide, H. Kobayashi, H. Ujike, N. Ozaki, Y. Sekine, T. Inada, M. Harano, T. Komiyama, M. Yamada, M. Iyo, N. Iwata, K. Tanaka, H. Shen, K. Iwahashi, M. Itokawa, M. Minami, M. Satoh, K. Ikeda, I. Sora

  May 2006, PHARMACOGENOMICS JOURNAL, 6(3) (3), 179 - 188, English, International magazine

  Scientific journal


• Morphine can produce analgesia via spinal kappa opioid receptors in the absence of mu opioid receptors

  H Yamada, N Shimoyama, Sora, I, GR Uhl, Y Fukuda, H Moriya, M Shimoyama

  Apr. 2006, BRAIN RESEARCH, 1083(1) (1), 61 - 69, English, International magazine

  Scientific journal


• Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia

  M Arai, K Yamada, T Toyota, N Obata, S Haga, Y Yoshida, K Nakamura, Y Minabe, H Ujike, Sora, I, K Ikeda, N Mori, T Yoshikawa, M Itokawa

  Apr. 2006, BIOLOGICAL PSYCHIATRY, 59(7) (7), 652 - 659, English, International magazine

  Scientific journal


• Involvement of the 3 ' non-coding region of the mu opioid receptor gene in morphine-induced analgesia

  S Kasai, WH Han, S Ide, H Hata, Y Takamatsu, H Yamamoto, GR Uhl, Sora, I, K Ikeda

  Apr. 2006, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 60, S11 - S17, English

  Scientific journal


• 精神的ストレス誘発性喘息におけるμ-オピオイド受容体の関与

  奥山 香織, 荒井 良枝, 梶川 聡子, 成瀬 茉耶, 田村 弦, 櫻田 忍, 曽良 一郎, 高柳 元明, 大野 勲

  (公社)日本薬学会, Mar. 2006, 日本薬学会年会要旨集, 126年会(3) (3), 144 - 144, Japanese


• Positive association of AKT1 haplotype to Japanese methamphetamine use disorder

  M Ikeda, N Iwata, T Suzuki, T Kitajima, Y Yamanouchi, Y Kinoshiya, Y Sekine, M Iyo, M Harano, T Komiyama, M Yamada, Sora, I, H Ujike, T Inada, N Ozaki

  Feb. 2006, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 9(1) (1), 77 - 81, English, International magazine

  Scientific journal


• dextro- and levo-morphine attenuate opioid delta and kappa receptor agonist produced analgesia in mu-opioid receptor knockout mice

  H Wu, HS Sun, M Terashivili, E Schwasinger, Sora, I, FS Hall, GR Uhl, LF Tseng

  Feb. 2006, EUROPEAN JOURNAL OF PHARMACOLOGY, 531(1-3) (1-3), 103 - 107, English, International magazine

  Scientific journal


• Gastrointestinal transit inhibition by oxycodone and fentanyl is mediated by mu-opioid receptor

  H Hata, H Kobayashi, H Komatsu, Sora, I

  2006, JOURNAL OF PHARMACOLOGICAL SCIENCES, 100, 251P - 251P, English


• (-)-Pentazocine thermal and mechanical antinociception are eliminated and chemical antinociception reduced in mu-opioid receptor knockout mice

  S Ide, M Minami, GR Uhl, K Ishihara, Sora, I, K Ikeda

  2006, JOURNAL OF PHARMACOLOGICAL SCIENCES, 100, 254P - 254P, English


• Association study of the dihydropyrimidinase-related protein 2 gene and methamphetamine psychosis

  H. Ujike, A. Sakai, K. Nakata, Y. Tanaka, T. Kodaka, Y. Okahisa, M. Harano, T. Inada, M. Yamada, T. Komiyama, T. Hori, Y. Sekine, N. Iwata, I. Sora, M. Iyo, N. Ozaki, S. Kuroda

  2006, CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY: COCAINE, GHB, AND SUBSTITUTED AMPHETAMINES, 1074, 90 - 96, English, International magazine

  Scientific journal


• Repeated methamphetamine administration alters expression of the NMDA receptor channel epsilon 2 subunit and kinesins in the mouse brain

  Hideko Yamamoto, Kazuhide Imai, Etsuko Kamegaya, Yukio Takamatsu, Masashi Irago, Yoko Hagino, Sinya Kasai, Kiyo Shimada, Toshifumi Yamamoto, Ichiro Sora, Hisashi Koga, Kazutaka Ikeda

  2006, CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY: COCAINE, GHB, AND SUBSTITUTED AMPHETAMINES, 1074, 97 - 103, English, International magazine

  Scientific journal


• Association study of the tumor necrosis factor-alpha gene and its 1A receptor gene with methamphetamine dependence

  A. Nomura, H. Ujike, Y. Tanaka, M. Kishimoto, K. Otani, Y. Morita, A. Morio, M. Harano, T. Inada, M. Yamada, T. Komiyama, T. Hori, Y. Sekine, N. Iwata, I. Sora, M. Iyo, N. Ozaki, S. Kuroda

  2006, CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY: COCAINE, GHB, AND SUBSTITUTED AMPHETAMINES, 1074, 116 - 124, English, International magazine

  Scientific journal


• No association between CART (cocaine- and amphetamine-regulated transcript) gene and methamphetamine dependence

  A. Morio, H. Ujike, A. Nomura, Y. Tanaka, Y. Morita, K. Otani, M. Kishimoto, M. Harano, T. Inada, T. Komiyama, M. Yamada, Y. Sekine, N. Iwata, M. Iyo, I. Sora, N. Ozaki, S. Kuroda

  2006, CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY: COCAINE, GHB, AND SUBSTITUTED AMPHETAMINES, 1074, 411 - 417, English, International magazine

  Scientific journal


• Candidate gene analysis of methamphetamine-related disorders

  H Ujike, T Inada, M Harano, T Komiyama, M Yamada, Y Sekine, N Iwata, M Iyo, Sora, I, N Ozaki

  Dec. 2005, NEUROPSYCHOPHARMACOLOGY, 30, S24 - S25, English


• [Genetic analyses of morphine sensitivity].

  Ikeda K, Ogai Y, Nishizawa D, Ide S, Sora I

  Last, Dec. 2005, Nihon rinsho. Japanese journal of clinical medicine, 63 Suppl 12, 463 - 466, Japanese, Domestic magazine

  [Refereed]

  Scientific journal


• Characterization of the 3 ' untranslated region of the human mu-opioid receptor (MOR-1) mRNA

  S Ide, WH Han, S Kasai, H Hata, Sora, I, K Ikeda

  Dec. 2005, GENE, 364, 139 - 145, English, International magazine

  Scientific journal


• 未規制トリプタミン系薬物に関する乱用実態調査の試み

  小原 可久, 沼知 陽太郎, 小林 秀昭, 山下 元康, 渡邉 秀和, 福島 攝, 小松 浩, 畑 春実, 仲 真樹, 近江 香予, 曽良 一郎

  (公社)日本精神神経学会, Aug. 2005, 精神神経学雑誌, 107(8) (8), 903 - 903, Japanese


• 覚せい剤精神病におけるドパミンレセプターD2遺伝子TaqⅠA多型と脳MRI．

  原野睦生, 内村直尚, 上野雄文, 安陪等思, 石橋正彦, 飯田信夫, 田中得雄, 前田久雄, 曽良一郎, 伊豫雅臣, 橋本謙二, 小宮山徳太郎, 山田光彦, 関根吉統, 稲田俊也, 尾崎紀夫, 岩田仲生, 氏家寛

  覚醒剤関連障害の脆弱性を規定するとされる遺伝子多型の中でも最も代表的な遺伝子多型ドーパミン受容体D2(DRD2)遺伝子のtaq I A多型について,疾患との関わりをより明らかにするため,患者-対照群の相関解析を行うとともに,endophenotypeとしてMRIによる脳の形態にも着目し,Voxel-based morphometryによる解析,検討を行った.その結果,覚醒剤精神病とDRD2遺伝子taq IA多型との間に相関があること,覚醒剤精神病では左側頭葉と中脳(被蓋)が健常者に比べて狭小であること,A2/A2遺伝子型の罹患者では,特に中脳(被蓋)と左前頭葉下面(内側眼球回)が狭小であることが示された.以上の結果は,taq IA多型が覚醒剤精神病の発症・重篤化の規程因子であることを明らかにするとともに,左側頭葉と中脳の一部が責任部位である可能性を示唆するものである

  日本アルコール精神医学会, Aug. 2005, 日本アルコール精神医学雑誌, 12(1) (1), 33 - 41, Japanese

  [Refereed]

  Scientific journal


• The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence

  Y Morita, H Ujike, Y Tanaka, N Uchida, A Nomura, K Otani, M Kishimoto, A Morio, T Inada, M Harano, T Komiyama, M Yamada, Y Sekine, N Iwata, M Iyo, Sora, I, N Ozaki

  Jul. 2005, NEUROSCIENCE LETTERS, 383(1-2) (1-2), 194 - 198, English

  Scientific journal


• Methamphetamine modulation of gene expression in the brain: Analysis using customized cDNA microarray system with the mouse homologues of KIAA genes

  H Yamamoto, K Imai, Y Takamatsu, E Kamegaya, M Kishida, Y Hagino, Y Hara, K Shimada, T Yamamoto, Sora, I, H Koga, K Ikeda

  Jun. 2005, MOLECULAR BRAIN RESEARCH, 137(1-2) (1-2), 40 - 46, English, International magazine

  Scientific journal


• Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis

  S Ohgake, K Hashimoto, E Shimizu, H Koizumi, N Okamura, K Koike, D Matsuzawa, Y Sekine, T Inada, N Ozaki, N Iwata, M Harano, T Komiyama, M Yamada, Sora, I, H Ujike, Y Shirayama, M Iyo

  Jun. 2005, ADDICTION BIOLOGY, 10(2) (2), 145 - 148, English, International magazine

  Scientific journal


• How individual sensitivity to opiates can be predicted by gene analyses

  K Ikeda, S Ide, WH Han, M Hayashida, GR Uhl, Sora, I

  Jun. 2005, TRENDS IN PHARMACOLOGICAL SCIENCES, 26(6) (6), 311 - 317, English, International magazine

  Scientific journal


• A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population

  T Hashimoto, K Hashimoto, D Matsuzawa, E Shimizu, Y Sekine, T Inada, N Ozaki, N Iwata, M Harano, T Komiyama, M Yamada, Sora, I, H Ujike, M Iyo

  May 2005, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 135B(1) (1), 5 - 9, English, International magazine

  Scientific journal


• A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia

  Y Morita, H Ujike, Y Tanaka, N Uchida, A Nomura, K Ohtani, M Kishimoto, A Morio, T Imamura, A Sakai, T Inada, M Harano, T Komiyama, M Yamada, Y Sekine, N Iwata, M Iyo, Sora, I, N Ozaki, S Kuroda

  Mar. 2005, NEUROSCIENCE LETTERS, 376(3) (3), 182 - 187, English, International magazine

  Scientific journal


• Role of endomorphin-1 on the process of learning and memory in the water-finding test in mice.

  T Mamiya, Sora, I, G Uhl, M Ukai

  2005, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 60P - 60P, English


• Methamphetamine-induced hyperthermia and lethality in dopamine and/or serotonin transporter knockout mice

  Y Numachi, A Ohara, H Kobayashi, M Yamashita, S Fukushima, K Ohmi, H Hata, H Watanabe, M Naka, Sora, I

  2005, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 151P - 151P, English


• Role of endomorphin-1 on the process of learning and memory in the water-finding test in mice

  T Mamiya, Sora, I, G Uhl, M Ukai

  2005, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 101P - 101P, English


• The analyses of the antinociceptive and rewarding effects of buprenorphine and tramadol in mu-opioid receptor knockout mice

  S Ide, M Minami, GR Uhl, K Ishihara, Sora, I, K Ikeda

  2005, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 203P - 203P, English


• Role of monoamine re-uptake by cognate monoamine transporter

  H Kobayashi, M Naka, K Ohmi, Y Numachi, Sora, I

  2005, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 164P - 164P, English


• 覚醒剤精神病におけるChromogranin A遺伝子の解析

  Maeda,'' Takaki

  2005, 科学技術振興調整費目標達成型脳科学研究「依存性薬物により誘発される精神障害の機構の解明の研究」平成16年度調査研究成果報告書, 102-109, Japanese

  Scientific journal


• Haplotype association between GABA(A) receptor gamma 2 subunit gene (GABRG2) and methamphetamine use disorder

  T Nishiyama, M Ikeda, N Iwata, T Suzuki, T Kitajima, Y Yamanouchi, Y Sekine, M Iyo, M Harano, T Komiyama, M Yamada, Sora, I, H Ujike, T Inada, TA Furukawa, N Ozaki

  2005, PHARMACOGENOMICS JOURNAL, 5(2) (2), 89 - 95, English, International magazine

  Scientific journal


• Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan

  K Itoh, K Hashimoto, E Shimizu, Y Sekine, N Ozaki, T Inada, M Harano, N Iwata, T Komiyama, M Yamada, Sora, I, K Nakata, H Ujike, M Iyo

  Jan. 2005, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 132B(1) (1), 70 - 73, English, International magazine

  Scientific journal


• Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters

  HW Shen, Y Hagino, H Kobayashi, K Shinohara-Tanaka, K Ikeda, H Yamamoto, T Yamamoto, KP Lesch, DL Murphy, FS Hall, GR Uhl, Sora, I

  Last, Oct. 2004, NEUROPSYCHOPHARMACOLOGY, 29(10) (10), 1790 - 1799, English, International magazine, Co-authored internationally

  Scientific journal


• Association between TaqI a polymorphism of DRD2 gene and cerebral form in methamphetamine psychosis

  M Harano, N Uchimura, M Ueno, H Abe, M Ishibashi, N Iida, T Tanaka, H Maeda, Sora, I, M Iyo, T Komiyama, M Yamada, Y Sekine, T Inada, N Ozaki, N Iwata, H Ujike

  Sep. 2004, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 130B(1) (1), 109 - 109, English


• The prodynorphin gene promoter is associated with methamphetamine dependence in Japanese population

  A Nomura, H Ujike, Y Tanaka, M Hrano, T Inada, M Yamada, T Komiyama, Y Sekine, N Iwata, Sora, I, M Iyo, N Ozaki, S Kuroda

  Sep. 2004, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 130B(1) (1), 111 - 111, English


• Buprenorphine antinociception is abolished, but naloxone-sensitive reward is retained, in mu-opioid receptor knockout mice

  S Ide, M Minami, M Satoh, GR Uhl, Sora, I, K Ikeda

  Sep. 2004, NEUROPSYCHOPHARMACOLOGY, 29(9) (9), 1656 - 1663, English, International magazine, Co-authored internationally

  Scientific journal


• Association study of polymorphisms in the 5 ' upstream region of human DISC1 gene with schizophrenia

  TTJP Kockelkorn, M Arai, H Matsumoto, N Fukuda, K Yamada, Y Minabe, T Toyota, H Ujike, Sora, I, N Mori, T Yoshikawa, M Itokawa

  Sep. 2004, NEUROSCIENCE LETTERS, 368(1) (1), 41 - 45, English, International magazine

  Scientific journal


• Molecular mechanisms underlying behavioral effects of cocaine: Lessons from knockout mice

  E. Scott Hall, Ichiro Sora, George R. Uhl

  Jun. 2004, Current Pharmacogenomics, 2(2) (2), 185 - 202, English


• Low dose endomorphin-1 improvement of scopolamine-induced memory impairment: MU-independent mechanisms

  M Hiramatsu, H Tarukado, Sora, I, G Uhl

  Jun. 2004, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 7, S298 - S298, English


• Association of neural cell adhesion molecule 1 gene polymorphisms with bipolar affective disorder in Japanese individuals

  M Arai, M Itokawa, K Yamada, T Toyota, M Arai, S Haga, H Ujike, Sora, I, K Ikeda, T Yoshikawa

  Apr. 2004, BIOLOGICAL PSYCHIATRY, 55(8) (8), 804 - 810, English, International magazine

  Scientific journal


• Nerve injury induces a tonic bilateral mu-opioid receptor-mediated inhibitory effect on mechanical allodynia in mice

  H Mansikka, CS Zhao, RN Sheth, Sora, I, G Uhl, SN Raja

  Apr. 2004, ANESTHESIOLOGY, 100(4) (4), 912 - 921, English, International magazine

  Scientific journal


• An association study of a SOD2 gene polymorphism to methamphetamine psychosis

  K Nakamura, Y Sekine, N Osada, A Suzuki, Y Minabe, N Takei, K Suzuki, Y Iwata, M Kawai, K Takebayashi, M Iyo, N Ozaki, T Inada, M Harano, T Komiyama, M Yamada, Sora, I, H Ujike, N Mori

  Feb. 2004, SCHIZOPHRENIA RESEARCH, 67(1) (1), 58 - 58, English


• mu-opioid receptor knockout mice display reduced cocaine conditioned place preference but enhanced sensitization of cocaine-induced locomotion

  FS Hall, M Goeb, XF Li, I Sora, GR Uhl

  Feb. 2004, MOLECULAR BRAIN RESEARCH, 121(1-2) (1-2), 123 - 130, English, International magazine

  Scientific journal


• Monoamine neurotransmission and mental disorders

  Sora, I, HW Shen, H Kobayashi, K Ikeda, Y Numachi

  2004, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 16P - 16P, English


• Psychostimulant alters expression of DNA methyltransferase mRNA in the rat brain

  Y Numachi, S Yoshida, M Yamashita, K Fujiyama, M Naka, H Matsuoka, M Sato, Sora, I

  Last, 2004, CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY, 1025, 102 - 109, English, International magazine

  Scientific journal


• Gene polymorphisms of the Mu opioid receptor in methamphetamine abusers

  S Ide, H Kobayashi, K Tanaka, H Ujike, Y Sekine, N Ozaki, T Inada, M Harano, T Komiyama, M Yamada, M Iyo, K Ikeda, Sora, I

  Last, 2004, CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY, 1025, 316 - 324, English, International magazine

  Scientific journal


• No association found between the type 1 sigma receptor gene polymorphisms and methamphetamine abuse in the Japanese population

  T Inada, Y Iijima, N Uchida, T Maeda, S Iwashita, N Ozaki, M Harano, T Komiyama, M Yamada, Y Sekine, M Iyo, Sora, I, H Ujike

  2004, CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY, 1025, 27 - 33, English, International magazine

  Scientific journal


• No association is found between the candidate genes of t-PA/plasminogen system and Japanese methamphetamine-related disorder - A collaborative study by the Japanese genetics initiative for drug abuse

  N Iwata, T Inada, M Harano, T Komiyama, M Yamada, Y Sekine, M Iyo, Sora, I, H Ujike, N Ozaki

  2004, CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY, 1025, 34 - 38, English, International magazine

  Scientific journal


• Molecular mechanisms underlying the rewarding effects of cocaine

  FS Hall, Sora, I, J Drgonova, XF Li, M Goeb, GR Uhl

  2004, CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY, 1025, 47 - 56, English, International magazine

  Scientific journal


• Changes in expression of the mouse homologues of KIAA genes after subchronic methamphetamine treatment

  H Yamamoto, K Imai, Y Takamatsu, E Kamegaya, Y Hara, K Shimada, T Yamamoto, HW Shen, Y Hagino, H Kobayashi, S Ide, Sora, I, H Koga, K Ikeda

  2004, CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY, 1025, 92 - 101, English, International magazine

  Scientific journal


• Food-reinforced operant behavior in dopamine transporter knockout mice - Enhanced resistance to extinction

  N Hironaka, K Ikeda, Sora, I, GR Uhl, H Niki

  2004, CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY, 1025, 140 - 145, English, International magazine

  Scientific journal


• A polymorphism of DRD2 gene and brain atrophy in methamphetamine psychosis

  M Harano, N Uchimura, H Abe, M Ishibashi, N Iida, K Yanagimoto, T Tanaka, H Maeda, Sora, I, M Iyo, T Komiyama, M Yamada, Y Sekine, T Inada, N Ozaki, H Ujike

  2004, CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY, 1025, 307 - 315, English, International magazine

  Scientific journal


• Study of association between alpha-synuclein gene polymorphism and methamphetamine psychosis/dependence

  H Kobayashi, S Ide, J Hasegawa, H Ujike, Y Sekine, N Ozaki, T Inada, M Harano, T Komiyama, M Yamada, M Iyo, HW Shen, K Ikeda, Sora, I

  2004, CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY, 1025, 325 - 334, English, International magazine

  Scientific journal


• A possible genetic mechanism underlying individual and interstrain differences in opioid actions - Focus on the Mu opioid receptor gene

  WH Han, S Ide, Sora, I, H Yamamoto, K Ikeda

  2004, CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY, 1025, 370 - 375, English, International magazine

  Scientific journal


• 覚せい剤精神病患者におけるDRD2遺伝子TaqIA多型と脳MRI画像所見の相関研究

  原野 睦生, 内村 直尚, 安陪 等思, 石橋 正彦, 飯田 信夫, 田中 得雄, 前田 久雄, 氏家 寛, 小宮山 徳太郎, 関根 吉統, 稲田 俊也, 飯嶋 良味, 伊豫 雅臣, 橋本 謙二, 尾崎 紀夫, 曽良 一郎, 山田 光彦, 薬物依存ゲノム解析研究グループ

  九州精神神経学会, Dec. 2003, 九州神経精神医学, 49(3〜4) (3〜4), 200 - 201, Japanese

  [Refereed]


• Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders

  DL Murphy, GR Uhl, A Holmes, R Ren-Patterson, FS Hall, Sora, I, S Detera-Wadleigh, KP Lesch

  Dec. 2003, GENES BRAIN AND BEHAVIOR, 2(6) (6), 350 - 364, English, International magazine

  Scientific journal


• Lack of mu-opioid receptor-mediated G-protein activation in the spinal cord of mice lacking exon 1 or exons 2 and 3 of the MOR-1 gene

  H Mizoguchi, HE Wu, M Narita, Sora, I, FS Hall, GR Uhl, HH Loh, H Nagase, LF Tseng

  Dec. 2003, JOURNAL OF PHARMACOLOGICAL SCIENCES, 93(4) (4), 423 - 429, English, Domestic magazine

  Scientific journal


• Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis

  H Ujike, M Harano, T Inada, M Yamada, T Komiyama, Y Sekine, Sora, I, M Iyo, T Katsu, A Nomura, K Otani, Y Morita, N Ozaki, S Kuroda

  Sep. 2003, EUROPEAN NEUROPSYCHOPHARMACOLOGY, 13, S418 - S418, English

  [Refereed]

  Scientific journal


• Association between a novel polymorphism in the promoter region of the neuropeptide Y gene and schizophrenia in humans

  M Itokawa, M Arai, S Kato, Y Ogata, A Furukawa, S Haga, H Ujike, Sora, I, K Ikeda, T Yoshikawa

  Aug. 2003, NEUROSCIENCE LETTERS, 347(3) (3), 202 - 204, English, International magazine

  Scientific journal


• Caspase-independent cell death by low concentrations of nitric oxide in PC12 cells: Involvement of cytochrome c oxidase inhibition and the production of reactive oxygen species in mitochondria

  K Yuyama, H Yamamoto, Nishizaki, I, T Kato, Sora, I, T Yamamoto

  Aug. 2003, JOURNAL OF NEUROSCIENCE RESEARCH, 73(3) (3), 351 - 363, English, International magazine

  Scientific journal


• Overexpression of V-1 prevents nitric oxide-induced cell death: Involvement of enhanced tetrahydrobiopterin biosynthesis

  K Yuyama, H Yamamoto, K Nakamura, Nishizaki, I, T Yamakuni, SY Song, Sora, I, T Nagatsu, T Yamamoto

  Jun. 2003, JOURNAL OF NEUROSCIENCE RESEARCH, 72(6) (6), 716 - 725, English, International magazine

  Scientific journal


• Congenic C57BL/6 mu opiate receptor (MOR) knockout mice: baseline and opiate effects

  FS Hall, XF Li, M Goeb, S Roff, H Hoggatt, Sora, I, GR Uhl

  Apr. 2003, GENES BRAIN AND BEHAVIOR, 2(2) (2), 114 - 121, English, International magazine

  Scientific journal


• An association study of MAO-A gene polymorphism in methamphetamine psychosis

  K Nakamura, Y Sekine, N Osada, A Suzuki, Y Minabe, N Takei, K Suzuki, Y Iwata, M Kawai, M Iyo, N Ozaki, T Inada, M Harano, T Komiyama, H Mitsushio, T Maeda, S Iwashita, M Yamada, Sora, I, H Ujike, N Mori

  Mar. 2003, SCHIZOPHRENIA RESEARCH, 60(1) (1), 88 - 88, English


• Association study between polymorphisms in the promoter region of the alpha-synuclein gene and Alzheimer's disease

  H Ujike, N Uchida, A Sakai, H Kobayashi, J Hasegawa, M Yamamoto, Y Fujisawa, Kanzaki, Kohira, I, M Nakashima, Y Takehisa, Sora, I, S Kuroda

  2003, NEW TRENDS IN ALZHEIMER AND PARKINSON RELATED DISORDERS, 119 - 122, English

  [Refereed]

  International conference proceedings


• Antagonistic property of buprenorphine for epsilon-opioid receptor.

  H Mizoguchi, HE Wu, A Spaulding, M Narita, FS Hall, Sora, I, GR Uhl, H Nagase, LF Tseng, S Sakurada

  2003, JOURNAL OF PHARMACOLOGICAL SCIENCES, 91, 218P - 218P, English


• Receptor knock-out and gene targeting. Generation of knock-out mice.

  Ichiro Sora, Kazutaka Ikeda, Yuji Mishina

  2003, Methods in molecular medicine, 84, 205 - 216, English, International magazine

  Scientific journal


• Opioid receptor coupling to GIRK channels. In vitro studies using a Xenopus oocyte expression system and in vivo studies on weaver mutant mice.

  Kazutaka Ikeda, Mitsunobu Yoshii, Ichiro Sora, Toru Kobayashi

  2003, Methods in molecular medicine, 84, 53 - 64, English, International magazine

  Scientific journal


• Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis

  H Ujike, M Harano, T Inada, M Yamada, T Komiyama, Y Sekine, Sora, I, M Iyo, T Katsu, A Nomura, K Nakata, N Ozaki

  2003, PHARMACOGENOMICS JOURNAL, 3(4) (4), 242 - 247, English, International magazine

  Scientific journal


• Molecular mechanisms of analgesia induced by opioids and ethanol: is the GIRK channel one of the keys?

  K Ikeda, T Kobayashi, T Kumanishi, R Yano, Sora, I, H Niki

  Oct. 2002, NEUROSCIENCE RESEARCH, 44(2) (2), 121 - 131, English


• Effects of acute "binge" cocaine on preprodynorphin, preproenkephalin, proopiomelanocortin, and corticotropin-releasing hormone receptor mRNA levels in the striatum and hypothalamic-pituitary-adrenal axis of mu-opioid receptor knockout mice

  Y Zhou, R Spangler, SD Schlussman, VP Yuferov, Sora, I, A Ho, GR Uhl, MJ Kreek

  Sep. 2002, SYNAPSE, 45(4) (4), 220 - 229, English, International magazine

  Scientific journal


• Association study between methamphetamine psychosis and the dopamine transporter gene polymorphisms

  H Ujike, K Nakata, M Takaki, M Harano, T Komiyama, H Mitsushio, Y Sekine, T Inada, T Maeda, S Iwashita, M Yamada, Sora, I, M Iyo, N Ozaki

  Aug. 2002, INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 17, S45 - S46, English


• Differential mechanism of G-protein activation induced by endogenous mu-opioid peptides, endomorphin and beta-endorphin

  H Mizoguchi, LF Tseng, T Suzuki, Sora, I, M Narita

  Jul. 2002, JAPANESE JOURNAL OF PHARMACOLOGY, 89(3) (3), 229 - 234, English, Domestic magazine

  Scientific journal


• MS-377, a selective sigma receptor ligand, indirectly blocks the action of PCP in the N-methyl-D-aspartate receptor ion-channel complex in primary cultured rat neuronal cells

  J Karasawa, H Yamamoto, T Yamamoto, N Sagi, K Horikomi, Sora, I

  Feb. 2002, LIFE SCIENCES, 70(14) (14), 1631 - 1642, English, International magazine

  Scientific journal


• Different morphine actions in mu opioid receptor gene mutant mice

  Sora, I, S Ide, M Funada, K Shinohara-Tanaka, H Hata, H Kobayashi, FS Hall, GR Uhi, K Ikeda

  2002, JAPANESE JOURNAL OF PHARMACOLOGY, 88, 85P - 85P, English


• Cocaine mechanisms: Enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions

  FS Hall, XF Li, Sora, I, F Xu, M Caron, KP Lesch, DL Murphy, GR Uhl

  2002, NEUROSCIENCE, 115(1) (1), 153 - 161, English, International magazine

  Scientific journal


• Antagonistic property of buprenorphine for putative epsilon-opioid receptor-mediated G-protein activation by beta-endorphin in pons/medulla of the mu-opioid receptor knockout mouse

  H Mizoguchi, HE Wu, M Narita, FS Hall, Sora, I, GR Uhl, H Nagase, LF Tseng

  2002, NEUROSCIENCE, 115(3) (3), 715 - 721, English, International magazine

  Scientific journal


• Outline for generation and analysis of opioid receptor knockout mice

  Ichiro Sora, Kazutaka Ikeda, Yuji Mishina

  2002, Folia Pharmacologica Japonica, 120(1) (1), 47 - 54, Japanese

  Scientific journal


• 遺伝子変異動物を用いた疾患モデル

  曽良 一郎

  Dec. 2001, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 21(6) (6), 205 - 205, Japanese


• コカイン報酬の分子機構

  曽良一郎, 荻野洋子, 沈昊偉, 田中(篠原)慶子, HALLF.S, LESCHK.P, MURPHYD.L, UHLG.R, 池田和隆, 山本敏文, 山本秀子

  Dec. 2001, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 21(6) (6), 354 - 354, Japanese


• 遺伝子改変動物を用いた薬物依存の研究

  曽良一郎

  Nov. 2001, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 21(5) (5), 163 - 164, Japanese


• First-stage genome-wide Sib-pair linkage analysis of schizophrenia in Japanese

  Y. Okazaki, T. Tsujita, T. Arinami, T. Yoshikawa, Y. Fukumaki, T. Inada, T. Someya, M. Mineta, H. Ujike, N. Ozaki, K. Ohara, O. Ohmori, T. Kojima, S. Nanko, T. Sasaki, H. Yoneda, I. Kusumi, H. Fukuzako, J. Akiyosi, H. Arai, M. Harano, T. Kato, M. Nibuya, S. Niwa, I. Sora, N. Tashiro

  Oct. 2001, American Journal of Medical Genetics - Neuropsychiatric Genetics, 105(7) (7), 604, English

  Scientific journal


• First-stage genome-wide sib-pair linkage analysis of schizophrenia in Japanese

  Y Okazaki, T Tsujita, T Arinami, T Yoshikawa, Y Fukumaki, T Inada, T Someya, M Mineta, H Ujike, N Ozaki, K Ohara, O Ohmori, T Kojima, S Nanko, T Sasaki, H Yoneda, Kusumi, I, H Fukuzako, J Akiyosi, H Arai, M Harano, T Kato, M Nibuya, S Niwa, Sora, I, N Tashiro

  Oct. 2001, AMERICAN JOURNAL OF MEDICAL GENETICS, 105(7) (7), 604 - 604, English


• Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release

  AM Persico, E Mengual, R Moessner, SF Hall, RS Revay, Sora, I, J Arellano, J DeFelipe, JM Gimenez-Amaya, M Conciatori, R Marino, A Baldi, S Cabib, T Pascucci, GR Uhl, DL Murphy, KP Lesch, F Keller

  Sep. 2001, JOURNAL OF NEUROSCIENCE, 21(17) (17), 6862 - 6873, English, International magazine

  Scientific journal


• Multiple pathways of sigma(1) receptor ligand uptakes into primary cultured neuronal cells

  H Yamamoto, J Karasawa, N Sagi, S Takahashi, K Horikomi, S Okuyama, T Nukada, Sora, I, T Yamamoto

  Aug. 2001, EUROPEAN JOURNAL OF PHARMACOLOGY, 425(1) (1), 1 - 9, English, International magazine

  Scientific journal


• mu opiate receptor gene dose effects on different morphine actions: Evidence for differential in vivo mu receptor reserve

  Sora, I, G Elmer, M Funada, J Pieper, XF Li, FS Hall, GR Uhl

  Jul. 2001, NEUROPSYCHOPHARMACOLOGY, 25(1) (1), 41 - 54, English, International magazine

  Scientific journal


• Molecular mechanisms of cocaine reward: Combined dopamine and serotonin transporter knockouts eliminate cocaine place preference

  Sora, I, FS Hall, AM Andrews, M Itokawa, XF Li, HB Wei, C Wichems, KP Lesch, DL Murphy, GR Uhl

  Apr. 2001, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98(9) (9), 5300 - 5305, English, International magazine

  Scientific journal


• Dopaminergic role in stimulant-induced wakefulness

  JP Wisor, S Nishino, Sora, I, GH Uhl, E Mignot, DM Edgar

  Mar. 2001, JOURNAL OF NEUROSCIENCE, 21(5) (5), 1787 - 1794, English, Co-authored internationally

  [Refereed]

  Scientific journal


• 脳・神経系実験動物モデル テクニック・方法論 精神疾患モデルとしての遺伝子改変動物

  那波 宏之, 任海 学, 染矢 俊幸, 曽良 一郎

  近年の遺伝子操作,胚操作技術の躍進と共に数百系統にも及ぶ神経関連の遺伝子のノックアウトマウスが作られ,それらの脳機能が解析されいる.中には従来の精神疾患の発症仮説に合うものも,合わないものも出現し,種々の精神疾患のモデル動物としての利用可能性が取りざたされている.おもな精神疾患に関連する遺伝子改変マウスを紹介し,該当する精神疾患との関連性について述べた

  (株)先端医学社, Mar. 2001, 分子精神医学, 1(2) (2), 159 - 163, Japanese


• Ethanol consumption and reward are decreased in mu-opiate receptor knockout mice

  FS Hall, Sora, I, GR Uhl

  Feb. 2001, PSYCHOPHARMACOLOGY, 154(1) (1), 43 - 49, English, Co-authored internationally

  [Refereed]

  Scientific journal


• 遺伝子改変による精神分裂病モデル動物の開発 (特集 精神分裂病へのアプローチ--次世代への展望)

  曽良 一郎

  先端医学社, Jan. 2001, 分子精神医学, 1(1) (1), 27 - 34, Japanese


• 薬物依存の分子医学 (特集 精神疾患の分子医学--基礎と臨床) -- (臨床)

  曽良 一郎, 山本 秀子

  現代医療社, 2001, 現代医療, 33(11) (11), 2742 - 2747, Japanese


• The VMAT2 gene in mice and humans: amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins

  GR Uhl, S Li, N Takahashi, K Itokawa, ZC Lin, M Hazama, Sora, I

  Dec. 2000, FASEB JOURNAL, 14(15) (15), 2459 - 2465, English, International magazine

  [Refereed]

  Scientific journal


• Barrel pattern formation requires serotonin uptake by thalamocortical afferents, while vesicular monoamine release is necessary for development of supragranular layers

  AM Persico, E Mengual, R Moessner, RS Revay, Sora, I, J Arellano, J DeFelipe, JM Gimenez-Amaya, M Conciatori, R Marino, A Baldi, S Cabib, T Pascucci, GR Uhl, DL Murphy, KP Lesch, F Keller

  Sep. 2000, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 440(5) (5), R34 - R34, English


• Stress-induced analgesia in mu-apioid receptor knockout mice reveals normal function of the delta-opioid receptor system

  CJ LaBuda, Sora, I, GR Uhl, PN Fuchs

  Jun. 2000, BRAIN RESEARCH, 869(1-2) (1-2), 1 - 5, English, Co-authored internationally

  [Refereed]

  Scientific journal


• Enhanced delta-opioid receptor-mediated antinociception in mu-opioid receptor-deficient mice (vol 387, pg 163, 2000)

  CY Qiu, Sora, I, K Ren, G Uhl, R Dubner

  May 2000, EUROPEAN JOURNAL OF PHARMACOLOGY, 397(1) (1), 227 - 227, English


• Functional genomics and gene knockout strategy

  Sora, I

  Apr. 2000, BIOLOGICAL PSYCHIATRY, 47(8) (8), 117S - 117S, English


• delta-opioid receptor agonists produce antinociception and [S-35]GTP gamma S binding in mu receptor knockout mice

  Y Hosohata, TW Vanderah, TH Burkey, MH Ossipov, CJ Kovelowski, Sora, I, GR Uhl, XY Zhang, KC Rice, WR Roeske, VJ Hruby, HI Yamamura, J Lai, F Porreca

  Feb. 2000, EUROPEAN JOURNAL OF PHARMACOLOGY, 388(3) (3), 241 - 248, English, Co-authored internationally

  [Refereed]

  Scientific journal


• Enhanced delta-opioid receptor-mediated antinociception in mu-opioid receptor-deficient mice

  CY Qiu, Sora, I, K Ren, G Uhl, R Dubner

  Jan. 2000, EUROPEAN JOURNAL OF PHARMACOLOGY, 387(2) (2), 163 - 169, English, Co-authored internationally

  [Refereed]

  Scientific journal


• Opioid receptor knockout mice

  SORA Ichiro

  mu, delta, kappa opioid receptors are target molecules for analgesia, reward and many physiological functions of opiates. Opioid receptor knockout mice generated by gene-targeting technology which can introduce mutation into specified locus provide invaluable animal models to elucidate the in vivo function of opiates and develop new therapeutic drugs. The disruptions of mu receptor expression decreases the nociceptive threshold to thermal stimuli and increases the threshold to visceral chemical stimuli paradoxically. Analgesia, reward, respiratory depression, constipation, immunosuppression and physical dependence induced by morphine are absent in mice lacking the mu receptor. These data show that the mu receptor is a molecular target for most effects of morphine, both therapeutic and side effects. mu Receptor expression is required for most delta receptor-mediated and some kappa receptor analgesic effects. These results support substantial roles for mu receptor in the analgesic properties of delta, kappa receptors. Cocaine and ethanol reward require mu receptor systems' intactness. Mice lacking the mu receptor will be a useful tool to study complex interactions between endogenous opiate and dopamine systems.

  Dec. 1999, Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 19(5) (5), 239 - 249, Japanese, Domestic magazine

  Scientific journal


• Heterozygous VMAT2 knockout mice display prolonged QT intervals: possible contributions to sudden death

  K Itokawa, Sora, I, CW Schindler, M Itokawa, N Takahashi, GR Uhl

  Aug. 1999, MOLECULAR BRAIN RESEARCH, 71(2) (2), 354 - 357, English, Co-authored internationally

  [Refereed]

  Scientific journal


• The mu opiate receptor as a candidate gene for pain: Polymorphisms, variations in expression, nociception, and opiate responses

  GR Uhl, Sora, I, ZJ Wang

  Jul. 1999, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(14) (14), 7752 - 7755, English, Co-authored internationally

  [Refereed]

  Scientific journal


• Characterization of mechanical withdrawal responses and effects of mu-, delta- and kappa-opioid agonists in normal and mu-opioid receptor knockout mice

  PN Fuchs, C Roza, Sora, I, G Uhl, SN Raja

  Mar. 1999, BRAIN RESEARCH, 821(2) (2), 480 - 486, English, Co-authored internationally

  [Refereed]

  Scientific journal


• Visceral chemical nociception in mice lacking mu-opioid receptors: effects of morphine, SNC80 and U-50,488

  Sora, I, XF Li, M Funada, S Kinsey, GR Uhl

  Feb. 1999, EUROPEAN JOURNAL OF PHARMACOLOGY, 366(2-3) (2-3), R3 - R5, English, Co-authored internationally

  [Refereed]

  Scientific journal


• The mu-opioid receptor gene-dose dependent reductions in G-protein activation in the pons/medulla and antinociception induced by endomorphins in mu-opioid receptor knockout mice

  H Mizoguchi, M Narita, DE Oji, C Suganuma, H Nagase, Sora, I, GR Uhl, EY Cheng, LF Tseng

  1999, NEUROSCIENCE, 94(1) (1), 203 - 207, English, Co-authored internationally

  [Refereed]

  Scientific journal


• Absence of G-protein activation by mu-opioid receptor agonists in the spinal cord of mu-opioid receptor knockout mice

  M Narita, H Mizoguchi, M Narita, Sora, I, GR Uhl, LF Tseng

  Jan. 1999, BRITISH JOURNAL OF PHARMACOLOGY, 126(2) (2), 451 - 456, English, Co-authored internationally

  [Refereed]

  Scientific journal


• Intravenous morphine self-administration in mu opiate receptor knockout mice. Significant receptor reserve indicated for the reinforcing effect of morphine

  GI Elmer, Sora, I, JO Pieper, G Uhl

  Oct. 1998, BRAIN RESEARCH, 809(1) (1), A22 - A22, English


• No heroin or morphine 6 beta-glucuronide analgesia in mu-opioid receptor knockout mice

  N Kitanaka, Sora, I, S Kinsey, ZZ Zeng, GR Uhl

  Aug. 1998, EUROPEAN JOURNAL OF PHARMACOLOGY, 355(1) (1), R1 - R3, English, Co-authored internationally

  [Refereed]

  Scientific journal


• Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice

  Sora, I, C Wichems, N Takahashi, XF Li, ZZ Zeng, R Revay, KP Lesch, DL Murphy, GR Uhl

  Jun. 1998, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 95(13) (13), 7699 - 7704, English, Co-authored internationally

  [Refereed]

  Scientific journal


• Mu opiate receptor genes, nociception and reward: Potential lessons in knockout mice, mouse strains and humans.

  Sora, I, S Hall, ZJ Wang, P Fuchs, XF Li, N Kitanaka, ZZ Zeng, SN Raja, GR Uhl

  1998, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 358(1) (1), R347 - R347, English


• Mu opiate receptor knock-out mice: Influence on pain, locomotion and reward models

  Sora, I, XF Ii, Z Zeng, S Kinsey, N Kitanaka, J Kitanaka, N Goodman, G Elmer, GR Uhl

  1998, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 358(1) (1), R347 - R347, English


• VMAT2 knockout mice: Heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

  N Takahashi, LL Miner, Sora, I, H Ujike, RS Revay, Kostic, V, JacksonLewis, V, S Przedborski, GR Uhl

  Sep. 1997, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 94(18) (18), 9938 - 9943, English, Co-authored internationally

  [Refereed]

  Scientific journal


• The mu-opioid receptor is necessary for [D-Pen(2),D-Pen(5)]enkephalin-induced analgesia

  Sora, I, M Funada, GR Uhl

  Apr. 1997, EUROPEAN JOURNAL OF PHARMACOLOGY, 324(2-3) (2-3), R1 - R2, English, Co-authored internationally

  [Refereed]

  Scientific journal


• Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia

  Sora, I, N Takahashi, M Funada, H Ujike, RS Revay, DM Donovan, LL Miner, GR Uhl

  Feb. 1997, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 94(4) (4), 1544 - 1549, English, Co-authored internationally

  [Refereed]

  Scientific journal


• Characterization of a cloned rat serotonin 5-HT1A receptor expressed in the HeLa cell line

  Yutaka Fujiwara, Hiroaki Tomita, Mitsuru Hikiji, Kenichi Kashihara, Saburo Otsuki, Tetsuo Ohnuki, Yasutaro Hamagishi, Toshikazu Oki, Ichiro Sora, William R. Roeske, Henry I. Yamamura

  1993, Life Sciences, 52(11) (11), 949 - 958, English

  [Refereed]

  Scientific journal


• LACK OF EFFECT OF HALOPERIDOL OR METHAMPHETAMINE TREATMENT ON THE MESSENGER-RNA LEVELS OF 2 DOPAMINE D(2)-RECEPTOR ISOFORMS IN RAT-BRAIN

  SORA, I, Y FUJIWARA, H TOMITA, H ISHIZU, K AKIYAMA, S OTSUKI, HI YAMAMURA

  Dec. 1992, JAPANESE JOURNAL OF PSYCHIATRY AND NEUROLOGY, 46(4) (4), 967 - 973, English

  [Refereed]

  Scientific journal


• IONOTROPIC EXCITATORY AMINO-ACID RECEPTORS IN DISCRETE BRAIN-REGIONS OF KINDLED RATS

  K AKIYAMA, Y YONEDA, K OGITA, T ITOH, A DAIGEN, SORA, I, KOHIRA, I, H UJIKE, S OTSUKI

  Jul. 1992, BRAIN RESEARCH, 587(1) (1), 73 - 82, English

  [Refereed]

  Scientific journal


• Permanent increase in membrane-associated protein kinase C activity in the hippocampal kindled rat.

  I Kohira, K Akiyama, A Daigen, T Itoh, M Ono, K Morimoto, I Sora, S Otsuki

  Jun. 1992, The Japanese journal of psychiatry and neurology, 46(2) (2), 510 - 2, English, Domestic magazine

  Scientific journal


• Lack of Effect of Haloperidol or Methamphetamine Treatment on the mRNA Levels of Two Dopamine D, Receptor Isoforms in Rat Brain

  Ichiro Sora, Yutaka Fujiwara, Hiroaki Tomita, Hideki Ishizu, Kazufumi Akiyama, Saburo Otsuki, Henry I. Yamamura

  1992, Psychiatry and Clinical Neurosciences, 46(4) (4), 967 - 973, English

  [Refereed]

  Scientific journal


• LOCALIZATION OF THE MESSENGER-RNAS FOR 2 DOPAMINE D2-RECEPTOR ISOFORMS IN THE RAT-BRAIN

  Y FUJIWARA, SORA, I, H TOMITA, K AKIYAMA, S OTSUKI, HI YAMAMURA

  Dec. 1991, JAPANESE JOURNAL OF PSYCHIATRY AND NEUROLOGY, 45(4) (4), 897 - 902, English

  [Refereed]

  Scientific journal


• Long-lasting enhancement of the membrane-associated protein kinase C activity in the hippocampal kindled rat.

  A Daigen, K Akiyama, T Itoh, I Kohira, I Sora, K Morimoto, S Otsuki

  We demonstrated that only membrane-associated protein kinase C (PKC) activity increased in the bilateral hippocampus (HIPP) up to 4 weeks and in the amygdala/pyriform cortex (AM/PC) at 4 weeks after the last kindled seizure. The enhancement of the membrane-associated PKC activity exceeds the increase in the protein concentration, which was observed in part. The overwhelming increase in the PKC activity should be of significance in the long-term maintenance of the kindling phenomenon.

  Jun. 1991, The Japanese journal of psychiatry and neurology, 45(2) (2), 297 - 301, English, Domestic magazine

  Scientific journal


• Localization of the mRNAs for Two Dopamine D2 Receptor Isoforms in the Rat Brain

  Yutaka Fujiwara, Ichiro Sora, Hiroaki Tomita, Kazufumi Akiyama, Saburo Otsuki, Henry I. Yamamura

  1991, Psychiatry and Clinical Neurosciences, 45(4) (4), 897 - 902, English

  [Refereed]

  Scientific journal


• The molecular biology of dopamine receptors

  Y. Fujiwara, I. Sora, H. Tomita

  1991, Japanese Journal of Psychopharmacology, 11(3) (3), 187 - 196, Japanese, Domestic magazine

  Scientific journal


• Psychological aspects of families with epileptic patients: a study using general health questionnaire.

  T Kugoh, I Fukunishi, K Hosokawa, K Kashihara, I Sora

  Sep. 1989, The Japanese journal of psychiatry and neurology, 43(3) (3), 550 - 1, English, Domestic magazine

  Scientific journal


• ALTERATIONS OF THE MUSCARINIC CHOLINERGIC (MACH) RECEPTORS IN THE STRIATUM OF THE MPTP-INDUCED PARKINSONIAN MODEL IN MICE - INVITRO QUANTITATIVE AUTORADIOGRAPHICAL ANALYSIS

  K MIZUKAWA, N OGAWA, YH SORA, SORA, I

  Last, Oct. 1987, NEUROSCIENCE LETTERS, 81(1-2) (1-2), 105 - 110, English

  [Refereed]

  Scientific journal


• CHRONIC DIHYDROERGOTOXINE ADMINISTRATION INCREASES MUSCARINIC CHOLINERGIC RECEPTOR-BINDING IN AGED-RAT BRAIN

  N OGAWA, K MIZUKAWA, SORA, I

  Last, Aug. 1987, RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY, 57(2) (2), 149 - 159, English

  [Refereed]

  Scientific journal


• DEXAMETHASONE SUPPRESSION TEST AND NORADRENERGIC FUNCTION IN AFFECTIVE AND SCHIZOPHRENIC DISORDERS

  SORA, I, K NISHIMON, S OTSUKI

  Jun. 1986, BIOLOGICAL PSYCHIATRY, 21(7) (7), 621 - 631, English

  [Refereed]

  Scientific journal


• PLASMA-FREE MHPG, DEXTRAMETHAZONE SUPPRESSION TEST (DST), AND SERUM CPK IN AFFECTIVE AND SCHIZOPHRENIC DISORDERS

  SORA, I, K NISHIMON, Y FUJIWARA, T HARADA, M SATO, S OTSUKI

  Jan. 1986, NEUROCHEMICAL RESEARCH, 11(1) (1), 118 - 119, English


• [A study of incidence and symptoms in 71 patients with cavum septi pellucidi].

  K Akiyama, M Sato, I Sora, S Otsuki, A Wake, H Fukui, Y Takahashi, K Yanagida, M Sudara

  Seventy one patients with cavum septi pellucidi (CSP) were found among 2722 patients who had received computerized tomographic scanning. A clinical evaluation of these patients was made to examine incidence, clinical symptoms and neurological signs of CSP. The results obtained were as follows: 1) Incidence of CSP was 2.6% of the patients who visited outpatient clinic of a mental hospital. Sex ratio was M:F 1.9:1.0. 2) Age of onset of chief complaints mainly ranged from 10 to 30 years in male, and 10 to 60 years in female. 3) Complications of epileptic attacks and mental retardation were 22.5% and 9.9% of the patients with CSP, respectively. Frequency of these complications was significantly higher, as compared with the patients without CSP. 4) Chief complaints of the patients with CSP were; headache (43.1%), nausea and/or vomiting (23.8%), epileptic attacks (22.5%), dizziness (19.7%) and emotional instability (19.7%). 5) No neurological signs specific to CSP was found in this study. 6) EEG abnormality was found in 22 of 71 patients with CSP.

  Jun. 1983, No to shinkei = Brain and nerve, 35(6) (6), 575 - 81, Japanese, Domestic magazine

  Scientific journal


• [Clinical significance of the dexamethasone suppression test].

  K Nishimon, I Sora, M Sato, S Otsuki

  1983, Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 85(11) (11), 821 - 3, Japanese, Domestic magazine

  Scientific journal

• δオピオイド受容体作動薬KNT-127の抗うつ作用におけるμオピオイド受容体の役割

  森屋由紀, 森屋由紀, 笠原好之, 笠原好之, 笠原好之, 嶋田政史, 榊原泰史, 榊原泰史, 藤井秀明, 長瀬博, 井手聡一郎, 池田和隆, SCOTT HALL Frank, UHL George, 曽良一郎

  2023, 鎮痛薬・オピオイドペプチドシンポジウムプログラム・抄録集, 42nd (CD-ROM)


• 喘息免疫応答の亢進に関与するヒトμオピオイド受容体遺伝子-塩基多型

  宮坂 智充, 川上 佳織, 宮田 敏, 佐藤 美希, 目時 弘仁, 曽良 一郎, 山内 広平, 豊島 かおる, 宍戸 史, 佐々木 雅史, 高柳 元明, 大野 勲, 中村 豊

  日本臨床生理学会, Oct. 2022, 日本臨床生理学会雑誌, 52(4) (4), 58 - 58, Japanese


• A118G single-nucleotide polymorphism in the human μ-opioid receptor gene is associated with enhanced Th2 type immune response in asthma

  宮坂智充, 川上佳織, 中村豊, 宮田敏, 目時弘仁, 曽良一郎, 山内広平, 河野資, 下川宏明, 下川宏明, 高柳元明, 高橋知子, 大野勲

  2021, 日本呼吸器学会誌(Web), 10


• 【リスデキサンフェタミン】リスデキサンフェタミンの薬理

  曽良 一郎, 金 世賢, 木村 敦

  (有)科学評論社, Jul. 2020, 精神科, 37(1) (1), 57 - 61, Japanese


• オピオイド受容体遺伝子-塩基多型と喘息重症度の解析

  原田 真裕美, 宮坂 智充, 川上 佳織, 中村 豊, 宮田 敏, 佐藤 美希, 目時 弘仁, 曽良 一郎, 山内 広平, 河野 資, 下川 宏明, 高柳 元明, 高橋 知子, 大野 勲

  (公社)日本薬学会, Mar. 2020, 日本薬学会年会要旨集, 140年会, 27I - pm07S, Japanese


• Involvement of the single nucleotide polymorphism in the μ-opioid receptor gene in athma severity.

  原田真裕美, 宮坂智充, 川上佳織, 中村豊, 宮田敏, 佐藤美希, 目時弘仁, 曽良一郎, 山内広平, 河野資, 下川宏明, 高柳元明, 高橋知子, 大野勲

  2020, 日本薬学会年会要旨集(CD-ROM), 140th (Web)


• Involvement of A118G single-nucleotide polymorphism (SNP rs1799971) in the μ-opioid receptor gene with asthma exacerbation

  川上佳織, 宮坂智充, 中村豊, 宮田敏, 目時弘仁, 曽良一郎, 山内広平, 河野資, 下川宏明, 下川宏明, 高柳元明, 高橋知子, 大野勲

  2020, 日本呼吸器学会誌(Web), 9


• 摂食障害との鑑別が必要な体重減少を伴った嘔吐恐怖症の症例

  内藤 敦海, 谷藤 貴紀, 蓬莱 政, 木村 敦, 曽良 一郎

  (公社)日本精神神経学会, Jan. 2020, 精神神経学雑誌, 122(1) (1), 58 - 59, Japanese


• うつ症状が先行した進行性核上性麻痺の1例

  國廣 奈生, 塚本 亮, 木村 敦, 曽良 一郎

  (公社)日本精神神経学会, Jan. 2020, 精神神経学雑誌, 122(1) (1), 62 - 62, Japanese


• 行動嗜癖としてのインターネット・ゲーム障害

  曽良 一郎

  (一社)日本総合病院精神医学会, Nov. 2019, 総合病院精神医学, 31(Suppl.) (Suppl.), S - 80, Japanese


• 精神刺激薬の薬理作用機序と乱用・依存リスク

  曽良 一郎

  (株)星和書店, Oct. 2019, 臨床精神薬理, 22(10) (10), 959 - 965, Japanese


• 【精神医学における様々な仮説とモデルの今I】統合失調症の病態モデルとしての覚せい剤逆耐性現象

  曽良 一郎

  (株)星和書店, Sep. 2019, 精神科治療学, 34(9) (9), 1065 - 1069, Japanese


• インターネット依存について

  曽良 一郎

  (一社)日本総合病院精神医学会, Jul. 2019, 総合病院精神医学, 31(3) (3), 346 - 347, Japanese


• 統合失調症患者におけるBrexpiprazoleの使用経験

  菱本 明豊, 青山 慎介, 大塚 郁夫, 朴 秀賢, 蓬莱 政, 木村 敦, 新名 尚史, 山木 愛久, 曽良 一郎

  (公社)日本精神神経学会, Jun. 2019, 精神神経学雑誌, (2019特別号) (2019特別号), S409 - S409, Japanese


• 鑑別と診断に苦慮した遷延するアルコール離脱せん妄の一例

  長妻 渉, 新名 尚史, 塚本 亮, 木村 敦, 蓬莱 政, 大塚 郁夫, 青山 慎介, 菱本 明豊, 曽良 一郎

  (公社)日本精神神経学会, Jun. 2019, 精神神経学雑誌, (2019特別号) (2019特別号), S484 - S484, Japanese


• 妊娠経過中に躁症状や精神病症状を呈し、内分泌疾患が判明するまで診断に苦慮した1症例

  蓬莱 政, 青山 慎介, 大塚 郁夫, 新名 尚史, 森脇 光信, 倉持 裕子, 曽良 一郎

  (公社)日本精神神経学会, Jun. 2019, 精神神経学雑誌, (2019特別号) (2019特別号), S623 - S623, Japanese


• 統合失調症におけるマクロファージ遊走阻止因子(MIF)の血清濃度増加と遺伝子多型関連解析

  岡崎 賢志, 大塚 郁夫, 渡部 雄一郎, 朴 秀賢, 新名 尚史, 平田 尚士, 蓬莱 政, 染矢 俊幸, 曽良 一郎, 菱本 明豊

  (公社)日本精神神経学会, Jun. 2019, 精神神経学雑誌, (2019特別号) (2019特別号), S441 - S441, Japanese


• 気管支喘息(成人)病態 気管支喘息増悪におけるヒトμオピオイド受容体遺伝子一塩基多型の関与

  川上 佳織, 宮坂 智充, 中村 豊, 宮田 敏, 佐藤 美希, 目時 弘仁, 曽良 一郎, 山内 広平, 河野 資, 下川 宏明, 高柳 元明, 高橋 知子, 大野 勲

  (一社)日本アレルギー学会, May 2019, アレルギー, 68(4-5) (4-5), 539 - 539, Japanese


• うつ病の診断で加療中に、著しい嚥下機能障害と非典型的な亜昏迷様症状を呈し診断に苦慮した1例

  塚本 亮, 木村 敦, 新名 尚史, 蓬莱 政, 大塚 郁夫, 田宮 裕子, 青山 慎介, 朴 秀賢, 菱本 明豊, 曽良 一郎

  (公社)日本精神神経学会, Mar. 2019, 精神神経学雑誌, 121(3) (3), 233 - 233, Japanese


• オピオイド受容体遺伝子一塩基多型が喘息病態に及ぼす影響の解析

  原田真裕美, 宮坂智充, 川上佳織, 中村豊, 宮田敏, 佐藤美希, 目時弘仁, 曽良一郎, 山内広平, 河野資, 下川宏明, 下川宏明, 高柳元明, 高橋知子, 大野勲

  2019, 日本薬学会東北支部大会講演要旨集, 58th


• アルコール依存症にアルコール性心筋症が合併し、断酒により心機能が改善した症例

  塚本 亮, 菱本 明豊, 青山 慎介, 朴 秀賢, 田宮 裕子, 大塚 郁夫, 松山 賢一, 木村 敦, 蓬莱 政, 曽良 一郎

  (公社)日本精神神経学会, Jan. 2019, 精神神経学雑誌, 121(1) (1), 68 - 68, Japanese


• 【神経系のトランスポーター-Up to date】 トランスポーターと疾患 統合失調症

  Ichiro Sora, 山本愛久, 平田尚士

  (株)中外医学社, Jun. 2018, Clinical Neuroscience, 36(6) (6), 728 - 731, Japanese

  Introduction scientific journal


• セロトニントランスポーター欠損マウスの自閉症様行動はトリプトファン欠乏食によって改善する

  佐藤 敦志, 田中 美歩, 笠井 慎也, 萩野 洋子, 古田島 浩子, 柏井 洋文, 西藤 泰昌, 稲垣 真澄, 曽良 一郎, 水口 雅, 池田 和隆

  (一社)日本小児神経学会, May 2018, 脳と発達, 50(Suppl.) (Suppl.), S372 - S372, Japanese


• セロトニントランスポーター欠損マウスの自閉症様行動はトリプトファン欠乏食によって改善する

  佐藤 敦志, 田中 美歩, 笠井 慎也, 萩野 洋子, 古田島 浩子, 柏井 洋文, 西藤 泰昌, 稲垣 真澄, 曽良 一郎, 水口 雅, 池田 和隆

  (一社)日本小児神経学会, May 2018, 脳と発達, 50(Suppl.) (Suppl.), S372 - S372, Japanese


• 全身性エリテマトーデス加療中に急性精神病状態を呈し診断に難渋した症例

  塚本亮, 松山賢一, Hishimoto Akitoyo, 青山慎介, 朴秀賢, 田宮裕子, 大塚郁夫, 木村敦, 蓬莱政, Ichiro Sora

  (公社)日本精神神経学会, Mar. 2018, 精神神経学雑誌, 120(3) (3), 232 - 232, Japanese

  Meeting report


• 【成人の注意欠如・多動性障害(ADHD)の診断と治療】 AD/HDの神経薬理学

  SORA ICHIRO, 久保有美子, 江口典臣

  (株)アークメディア, Oct. 2017, 臨床精神医学, 46(10) (10), 1269 - 1274, Japanese

  Introduction scientific journal


• μオピオイド受容体欠損マウスにおけるストレスとアルコール嗜好性に対する雌雄差の解析

  森屋 由紀, 笠原 好之, 萩野 洋子, 池田 和隆, 曽良 一郎

  日本生物学的精神医学会・日本神経精神薬理学会, Sep. 2017, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 39回・47回, 161 - 161, Japanese


• 多施設共同大規模スタディーのために てんかんの発病防止に関する社会基盤の整備 遺伝情報に依拠した治療導入のための体制整備

  兼子 直, 岩城 弘隆, 廣瀬 伸一, 石井 敦士, 山本 達也, 矢野 珠巨, 村松 一洋, 池田 昭夫, 曽良 一郎, 渡辺 雅子, 原 広一郎, 猿渡 淳二, 山田 順子, 吉田 秀一

  (一社)日本てんかん学会, Sep. 2017, てんかん研究, 35(2) (2), 383 - 383, Japanese


• 日本人自殺既遂者におけるMIF遺伝子プロモーター領域機能的多型の関連解析(Association study of MIF promoter polymorphosms with suicide completers in the Japanese population)

  新名 尚史, 菱本 明豊, 大塚 郁夫, 岡崎 賢志, 朴 秀賢, 毛利 健太朗, 蓬莱 政, 江口 典臣, 木村 敦, 山木 愛久, 平田 尚士, 高橋 玄倫, 上野 易弘, 白川 治, 曽良 一郎

  日本生物学的精神医学会・日本神経精神薬理学会, Sep. 2017, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 39回・47回, 190 - 190, English


• PDCD11遺伝子の稀な変異と統合失調症の発症リスク 罹患同胞対家系の全エクソーム解析、ターゲットリシーケンス、および症例・対照研究

  保谷 智史, 渡部 雄一郎, 菱本 明豊, 布川 綾子, 金子 尚史, 村竹 辰之, 新名 尚史, 大塚 郁夫, 奥田 修二郎, 井上 絵美子, 井桁 裕文, 澁谷 雅子, 江川 純, 折目 直樹, 曽良 一郎, 染矢 俊幸

  日本生物学的精神医学会・日本神経精神薬理学会, Sep. 2017, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 39回・47回, 177 - 177, Japanese


• セロトニントランスポーターノックアウトおよびヘテロ欠損マウスにおける自閉症様行動とトリプトファン欠乏食による改善効果

  田中 美歩, 佐藤 敦志, 笠井 慎也, 萩野 洋子, 古田島 弘子, 柏井 洋文, 西藤 泰昌, 稲垣 真澄, 曽良 一郎, 池田 和隆

  日本生物学的精神医学会・日本神経精神薬理学会, Sep. 2017, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 39回・47回, 151 - 151, Japanese


• 神経性やせ症における認知機能障害 下位分類による重症度の違い

  田宮 裕子, 大内 淳, 岩本 直子, 曽良 一郎

  (公社)日本精神神経学会, Jun. 2017, 精神神経学雑誌, (2017特別号) (2017特別号), S317 - S317, Japanese


• 抗NMDA受容体脳炎回復期の精神症状に対して修正型電気痙攣療法を施行した一例

  金 世賢, 青山 慎介, 大塚 郁夫, 宋 慎平, 朴 秀賢, 菱本 明豊, 曽良 一郎

  (公社)日本精神神経学会, Jun. 2017, 精神神経学雑誌, (2017特別号) (2017特別号), S485 - S485, Japanese


• JSNP Excellent Presentation Award for CINP2016:注意欠如/多動性障害モデルマウスにおけるメチルフェニデートの報酬効果の変化

  井手聡一郎, 高松幸雄, 池窪結子, TAK井手聡一郎, 高松幸雄, 池窪結子, Takeda TC, Nagasawa S, Hua J, Uhl GR, 曽良一郎, 池田和隆

  (一社)日本神経精神薬理学会, Apr. 2017, 日本神経精神薬理学雑誌, 37(2) (2), 49 - 50, Japanese

  Introduction scientific journal


• 脳機能からみたベンゾジアゼピン系薬剤のリスクとベネフィット 依存・耐性および認知機能への影響

  曽良 一郎, 蓬莱 政, 木村 敦, 松山 賢一

  (株)先端医学社, Mar. 2017, Depression Strategy, 7(1) (1), 7 - 9, Japanese


• μ-オピオイド受容体ノックアウトマウスのアルコール摂取量に及ぼす青年期ストレスの影響の性差(Sex Differences in the Effects of Adolescent Stress on Alcohol Consumption in μ-Opioid Receptor Knockout Mice)

  森屋 由紀, 笠原 好之, Hall F. Scott, Uhl George R., 曽良 一郎, 富田 博秋

  (一社)日本神経精神薬理学会, Nov. 2016, 日本神経精神薬理学雑誌, 36(5-6) (5-6), 123 - 124, Japanese


• 注意欠如/多動性障害モデルマウスにおけるメチルフェニデートの報酬効果

  池窪 結子, 井手 聡一郎, 高松 幸雄, Takeda Taishi-Clark, Nagasawa Sarah, Hua Jennifer, Uhl George R., 曽良 一郎, 池田 和隆

  (一社)日本アルコール・アディクション医学会, Aug. 2016, 日本アルコール・薬物医学会雑誌, 51(4) (4), 176 - 176, Japanese


• セロトニントランスポーターノックアウトおよびヘテロ欠損マウスにおける自閉症様行動とトリプトファン欠乏食による改善効果

  田中 美歩, 佐藤 敦志, 萩野 洋子, 曽良 一郎, 池田 和隆

  (一社)日本神経精神薬理学会, Jul. 2016, 日本神経精神薬理学会年会プログラム・抄録集, 46回, 225 - 225, Japanese


• 自殺既遂の生物学的研究

  Otsuka Ikuo, Ichiro Sora, 菱本明豊

  全世界の自殺者数は年間およそ100万人に上る。先進7ヶ国中で日本は圧倒的に自殺者が多く、若年層(15〜34歳)の死因では日本のみが自殺が事故死を大きく上回っている。個人が自殺に至る背景には了解可能なストレス因が存在する。自殺者のおよそ8割は精神疾患を合併していると言われる。双生児の自殺相対危険率が、一卵性双生児では二卵性双生児に比べ約17倍も高いことから、自殺危険率の違いは、環境因ではなく遺伝負因によるものと考えられる。自殺既遂の生物学的知見、自殺既遂研究の課題について概説した。

  (一社)日本神経精神薬理学会, Jun. 2016, 日本神経精神薬理学雑誌, 36(3) (3), 55 - 61, Japanese

  Introduction scientific journal


• モノアミン神経伝達とAD/HD

  Ichiro Sora

  (一社)日本小児神経学会, May 2016, 脳と発達, 48(Suppl.) (Suppl.), S212 - S212, Japanese

  Introduction scientific journal


• 統合失調症罹患同胞対・両親3家系のエクソーム解析および3段階関連解析

  布川綾子, 布川綾子, 渡部雄一郎, 澁谷雅子, 池田匡志, 菱本明豊, 近藤健治, 江川純, 金子尚史, 金子尚史, 村竹辰之, 村竹辰之, 齊藤竹生, 岡崎賢志, 島崎愛夕, 井桁裕文, 井上絵美子, 保谷智史, 須貝拓朗, 曽良一郎, 岩田仲生, 染矢俊幸

  2016, 日本生物学的精神医学会(Web), 38th


• 【依存症の分子病態解析】 報酬系にかかわる受容体と薬物依存

  Ichiro Sora, 菱本明豊

  (株)金芳堂, Jan. 2016, 脳21, 19(1) (1), 9 - 12, Japanese

  Introduction scientific journal


• 精神刺激薬によるドパミン作動性神経のホメオスタシス破綻への調節メカニズム モノアミン神経伝達に関わる遺伝子改変マウスを用いた精神疾患研究

  笠原 好之, 久保 有美子, 森屋 由紀, 有銘 預世布, 富田 博秋, 曽良 一郎

  (一社)日本アルコール・アディクション医学会, Aug. 2015, 日本アルコール・薬物医学会雑誌, 50(4) (4), 157 - 157, Japanese


• 統合失調症のニコチン依存におけるCadherin 13の役割

  大塚郁夫, Hishimoto Akitoyo, 渡部雄一郎, 朴秀賢, 笠原好之, Ichiro Sora

  (一社)日本アルコール・アディクション医学会, Aug. 2015, 日本アルコール・薬物医学会雑誌, 50(4) (4), 207 - 207, Japanese

  Meeting report


• Specific Regions Display Altered Grey Matter Volume in m-Opioid Receptor Knockout Mice: MRI Voxel-based Morphometry

  Ichiro Sora, Kazumasu Sasaki, Akira Sumiyoshi, Hiroi Nonaka, Yoshiyuki Kasahara, Kazutaka Ikeda, F. Scott Hall, George R. Uhl, Masahiko Watanabe, Ryuta Kawashima

  Dec. 2014, NEUROPSYCHOPHARMACOLOGY, 39, S134 - S135, English

  Summary international conference


• [Analysis of dopamine transporter knockout mice as an animal model of AD/HD].

  Yoshiyuki Kasahara, Yumiko Kubo, Ichiro Sora

  Nov. 2013, Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 33(5-6) (5-6), 185 - 9, Japanese, Domestic magazine

  [Refereed]


• 【依存性薬物作用機序から知る精神神経疾患の病態メカニズム】 中枢刺激薬作用機序から知るAD/HDの病態メカニズム

  笠原 好之, 久保 有美子, Ichiro Sora

  Nov. 2013, 日本神経精神薬理学雑誌, 33(5-6) (5-6), 185 - 189, Japanese

  Introduction scientific journal


• 統合失調症の臨床研究における評価スケールについて 包括的認知機能評価テストとしてのMATRICS-CCB

  曽良 一郎, 笹田 徹, 兼田 康宏

  日本臨床精神神経薬理学会・日本神経精神薬理学会, Oct. 2013, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 23回・43回, 112 - 112, Japanese


• ドーパミン薬理学の新展開 ドーパミントランスポーター欠損によるAD/HD様行動の発現

  池田 和隆, 高松 幸雄, 曽良 一郎

  日本臨床精神神経薬理学会・日本神経精神薬理学会, Oct. 2013, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 23回・43回, 138 - 138, Japanese


• 慢性疼痛へのセロトニン・ノルアドレナリン再取り込み阻害薬デュロキセチンの有効性

  大塚 郁夫, 白岩 恭一, 菱本 明豊, 毛利 健太朗, 笹田 徹, 曽良 一郎

  日本臨床精神神経薬理学会・日本神経精神薬理学会, Oct. 2013, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 23回・43回, 170 - 170, Japanese


• ドーパミントランスポーター欠損マウスが示す多動に対するメチルフェニデートの抑制効果には臨界期がある

  高松 幸雄, 佐藤 敦志, 久保 由美子, 長澤セーラ 幸恵, 田中 美歩, Uhl George, 曽良 一郎, 池田 和隆

  日本臨床精神神経薬理学会・日本神経精神薬理学会, Oct. 2013, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 23回・43回, 240 - 240, Japanese


• 統合失調症におけるIL-19遺伝子の発現量的形質遺伝子座(eQTL)におけるハプロタイプ解析

  岡崎 賢志, 渡部 雄一郎, 大塚 郁夫, 吉田 正邦, 白岩 恭一, 毛利 健太朗, ウォラパット・ラッタアーパー, イルワン・スプリヤント, 江口 典臣, 笹田 徹, 福武 将映, 布川 綾子, 染矢 俊幸, 白川 治, 菱本 明豊, 曽良 一郎

  日本臨床精神神経薬理学会・日本神経精神薬理学会, Oct. 2013, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 23回・43回, 230 - 230, Japanese


• 【物質使用障害とアディクション 臨床ハンドブック】 (第I部)物質使用障害とアディクションの生物学 中毒性精神病の生物学

  Ichiro Sora, 岡崎 賢志, Sasada Toru

  (株)星和書店, Oct. 2013, 精神科治療学, 28(増刊) (増刊), 31 - 34, Japanese

  [Invited]

  Introduction scientific journal


• 【発達障害】 発達障害の脳科学 ADHDの精神薬理学 モデル動物研究から

  池田 和隆, 高松 幸雄, Ichiro Sora

  Sep. 2013, 最新医学, 68(9月増刊) (9月増刊), 2126 - 2133, Japanese

  Introduction scientific journal


• [Genetic vulnerability of methamphetamine dependence].

  Yuki Moriya, Yoshiyuki Kasahara, Ichiro Sora

  Aug. 2013, Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 33(4) (4), 155 - 60, Japanese, Domestic magazine

  [Refereed]


• 【薬物依存に関与するタンパク性分子の発現と機能】 メタンフェタミン依存の遺伝的脆弱性要因

  森屋 由紀, 笠原 好之, Ichiro Sora

  Aug. 2013, 日本神経精神薬理学雑誌, 33(4号) (4号), 155 - 160, Japanese

  Introduction scientific journal


• Active behaviours produced by antidepressants and opioids in the mouse tail suspension test

  Esther Berrocoso, Kazutaka Ikeda, Ichiro Sora, George R. Uhl, Pilar Sanchez-Blazquez, Juan Antonio Mico

  Feb. 2013, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 16(1) (1), 151 - 162, English, International magazine


• 総合病院における他科入院患者への精神科リエゾン・コンサルテーションの現状 2

  上月遥, 川添文子, 磯部昌憲, 磯部昌憲, 大谷恭平, 高宮靜男, 白岩恭一, 大塚郁夫, 菱本明豊, 曽良一郎, 河野将英, 岡村健二, 北村登, 松石邦隆, 見野耕一

  2013, 総合病院精神医学, 25(Supplement) (Supplement)


• 総合病院における他科入院患者への精神科リエゾン・コンサルテーションの現状 1

  川添文子, 上月遥, 河村麻美子, 石川慎一, 大谷恭平, 高宮静男, 長谷川雅史, 白岩恭一, 大塚郁夫, 菱本明豊, 曽良一郎

  2013, 総合病院精神医学, 25(Supplement) (Supplement)


• 物質使用障害とアディクションの生物学 中毒性精神病の生物学

  Ichiro Sora, 岡﨑賢志, 笹田徹

  2013, 精神科治療学28（増刊号）, 28, 31 - 34, Japanese

  [Invited]

  Introduction commerce magazine


• Cortico-Subcortical Neuromodulation Involved in the Amelioration of Prepulse Inhibition Deficits in Dopamine Transporter Knockout Mice

  Yosefu Arime, Yoshiyuki Kasahara, F. Scott Hall, George R. Uhl, Ichiro Sora

  Oct. 2012, NEUROPSYCHOPHARMACOLOGY, 37(11) (11), 2522 - 2530, English


• Cortico-subcortical neuromodulation involved in the amelioration of prepulse inhibition deficits in dopamine transporter knockout mice.

  Yosefu Arime, Yoshiyuki Kasahara, F Scott Hall, George R Uhl, Ichiro Sora

  Oct. 2012, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(11) (11), 2522 - 30, English, International magazine

  [Refereed]


• mu-opioid Receptor-Mediated Alterations of Allergen-Induced Immune Responses of Bronchial Lymph Node Cells in a Murine Model of Stress Asthma

  Kaori Okuyama, Soichiro Ide, Shinobu Sakurada, Kazumasu Sasaki, Ichiro Sora, Gen Tamura, Yuichi Ohkawara, Motoaki Takayanagi, Isao Ohno

  Jun. 2012, ALLERGOLOGY INTERNATIONAL, 61(2) (2), 245 - 258, English


• μ-opioid receptor-mediated alterations of allergen-induced immune responses of bronchial lymph node cells in a murine model of stress asthma.

  Kaori Okuyama, Soichiro Ide, Shinobu Sakurada, Kazumasu Sasaki, Ichiro Sora, Gen Tamura, Yuichi Ohkawara, Motoaki Takayanagi, Isao Ohno

  Jun. 2012, Allergology international : official journal of the Japanese Society of Allergology, 61(2) (2), 245 - 58, English, International magazine

  [Refereed]


• 統合失調症における社会生活機能障害の評価・支援-MATRICS-CCB日本語版による認知機能障害の評価と治療計画への応用-MATRICSコンセンサス認知機能評価バッテリー日本語版の計量心理学的特性の検討

  兼田康宏, 大森哲郎, 岡久祐子, 住吉太幹, 朴盛弘, 高木学, 中込和幸, 曽良一郎

  2012, 統合失調症における社会生活機能障害の評価・支援-MATRICS-CCB日本語版による認知機能障害の評価と治療計画への応用 平成23年度 総括・分担研究報告書


• 統合失調症における社会生活機能障害の評価・支援-MATRICS-CCB日本語版による認知機能障害の評価と治療計画への応用-MATRICSコンセンサス認知機能評価バッテリー日本語版の計量心理学的特性に関する研究

  兼田康宏, 大森哲郎, 岡久祐子, 住吉太幹, 朴盛弘, 高木学, 中込和幸, 曽良一郎

  2012, 統合失調症における社会生活機能障害の評価・支援-MATRICS-CCB日本語版による認知機能障害の評価と治療計画への応用 平成21-23年度 総合研究報告書


• FACS-arrayによる統合失調症罹患者のTh1およびTh2細胞の遺伝子発現プロファイリング

  小野千晶, 兪志前, 小松浩, 小松浩, 石井直人, 曽良一郎, 富田博秋

  2012, 統合失調症研究, 2(1) (1)


• 微量脳組織におけるpH測定とその組織内発現プロファイルへの影響 ～死後脳研究とブレインバンク運営に有用な方法論の検討～

  小野千晶, 愈志前, 國井泰人, 和田明, 松本純弥, 日野瑞城, 池本桂子, 曽良一郎, 丹羽真一, 富田博秋

  2012, 統合失調症研究, 2(1) (1), 127


• 覚せい剤精神病の分子遺伝学的機序

  曽良一郎, 山崎圭太, 森屋由紀, 笠原好之, 十川千春, 北山滋雄, 花尻瑠理, 合田幸広, 池田和隆

  2012, 厚生労働科学研究費補助金 (医薬品・医療機器等レギュラトリーサイエンス総合研究推進事業), 乱用薬物による薬物依存の発症メカニズム・予防・診断及び治療法に関する研究, 平成23年度 総括研究報告書 (研究代表者: 鍋島俊隆), 76 - 86, Japanese


• 有罪知識や虚偽に関わる反応と認知機能成績の関係に関する検討 (基礎心理学研究)

  佐藤 愛, 岩崎 祥一, 宮澤 志保, 鈴木 大輔, 曽良 一郎

  2012, 基礎心理学研究, 30(2) (2), 223 - 223


• 精神科領域の用語解説 多能性幹細胞 (分子精神医学)

  曽良 一郎

  2012, 分子精神医学, 12(2) (2), 131 - 132


• 精神科領域の用語解説 多能性幹細胞 (分子精神医学)

  曽良 一郎

  2012, 分子精神医学, 12(2) (2), 131 - 132


• 有罪知識や虚偽に関わる反応と認知機能成績の関係に関する検討 (基礎心理学研究)

  佐藤 愛, 岩崎 祥一, 宮澤 志保, 鈴木 大輔, 曽良 一郎

  日本基礎心理学会, 2012, 基礎心理学研究, 30(2) (2), 223 - 223, Japanese


• シンポジウム特集「認知機能障害に対する治療をどう評価するか」

  曽良 一郎

  25 Nov. 2011, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 31(5) (5), 239 - 239, Japanese


• [Approaches to the development of the Japanese academic version of the MATRICS Consensus Cognitive Battery].

  Taku Sato, Ichiro Sora

  Nov. 2011, Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 31(5-6) (5-6), 241 - 4, Japanese, Domestic magazine

  [Refereed]


• Tryptophan Hydroxylase 2遺伝子多型とメタンフェタミン依存・精神病との相関

  曽良 一郎, 氏家 寛, 岩田 仲生, 稲田 俊也, 山田 光彦, 関根 吉統, 内村 直尚, 伊豫 雅臣, 尾崎 紀夫, 小林 秀昭

  (一社)日本アルコール・アディクション医学会, Aug. 2011, 日本アルコール・薬物医学会雑誌, 46(4) (4), 201 - 201, Japanese


• GDNF遺伝子とメタンフェタミン使用障害との関連解析

  臼井 比奈子, 吉村 智子, 氏家 寛, 稲田 俊也, 山田 光彦, 内村 直尚, 岩田 仲生, 曽良 一郎, 伊豫 雅臣, 尾崎 紀夫

  (一社)日本アルコール・アディクション医学会, Aug. 2011, 日本アルコール・薬物医学会雑誌, 46(4) (4), 202 - 202, Japanese


• Tryptophan Hydroxylase 2遺伝子多型とメタンフェタミン依存・精神病との相関 (日本アルコール・薬物医学会雑誌)

  曽良 一郎, 氏家 寛, 岩田 仲生, 稲田 俊也, 山田 光彦, 関根 吉統, 内村 直尚, 伊豫 雅臣, 尾崎 紀夫, 小林 秀昭

  (一社)日本アルコール・アディクション医学会, Aug. 2011, 日本アルコール・薬物医学会雑誌, 46(4) (4), 201 - 201, Japanese


• GDNF遺伝子とメタンフェタミン使用障害との関連解析 (日本アルコール・薬物医学会雑誌)

  臼井 比奈子, 吉村 智子, 氏家 寛, 稲田 俊也, 山田 光彦, 内村 直尚, 岩田 仲生, 曽良 一郎, 伊豫 雅臣, 尾崎 紀夫

  (一社)日本アルコール・アディクション医学会, Aug. 2011, 日本アルコール・薬物医学会雑誌, 46(4) (4), 202 - 202, Japanese


• Quantitative Detection of mu Opioid Receptor: Western Blot Analyses Using mu Opioid Receptor Knockout Mice

  Shinya Kasai, Hideko Yamamoto, Etsuko Kamegaya, George R. Uhl, Ichiro Sora, Masahiko Watanabe, Kazutaka Ikeda

  Mar. 2011, CURRENT NEUROPHARMACOLOGY, 9(1) (1), 219 - 222, English


• No Association Between GRM3 and Japanese Methamphetamine-Induced Psychosis

  Tomoko Tsunoka, Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Tomo Okochi, Takenori Okumura, Toshiya Inada, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

  Mar. 2011, CURRENT NEUROPHARMACOLOGY, 9(1) (1), 160 - 162, English


• Methylone and monoamine transporters: correlation with toxicity.

  Chiharu Sogawa, Norio Sogawa, Kazumi Ohyama, Ruri Kikura-Hanajiri, Yukihiro Goda, Ichiro Sora, Shigeo Kitayama

  Mar. 2011, Current neuropharmacology, 9(1) (1), 58 - 62, English, International magazine

  [Refereed]


• Lack of Association Between Prokineticin 2 Gene and Japanese Methamphetamine Dependence

  Taro Kishi, Tsuyoshi Kitajima, Tomoko Tsunoka, Takenori Okumura, Kunihiro Kawashima, Tomo Okochi, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

  Mar. 2011, CURRENT NEUROPHARMACOLOGY, 9(1) (1), 133 - 136, English


• Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese

  Takenori Okumura, Tomo Okochi, Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoko Kinoshita, Kunihiro Kawashima, Tomoko Tsunoka, Yasuhisa Fukuo, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Hiroshi Ujike, Nakao Iwata

  Mar. 2011, CURRENT NEUROPHARMACOLOGY, 9(1) (1), 155 - 159, English, International magazine


• Association Analysis of the Tryptophan Hydroxylase 2 Gene Polymorphisms in Patients with Methamphetamine Dependence/Psychosis

  Hideaki Kobayashi, Hiroshi Ujike, Nakao Iwata, Toshiya Inada, Mitsuhiko Yamada, Yoshimoto Sekine, Naohisa Uchimura, Masaomi Iyo, Norio Ozaki, Masanari Itokawa, Ichiro Sora

  Mar. 2011, CURRENT NEUROPHARMACOLOGY, 9(1) (1), 176 - 182, English, International magazine


• Association analysis of the adenosine A1 receptor gene polymorphisms in patients with methamphetamine dependence/psychosis.

  Hideaki Kobayashi, Hiroshi Ujike, Nakao Iwata, Toshiya Inada, Mitsuhiko Yamada, Yoshimoto Sekine, Naohisa Uchimura, Masaomi Iyo, Norio Ozaki, Masanari Itokawa, Ichiro Sora

  Mar. 2011, Current neuropharmacology, 9(1) (1), 137 - 42, English, International magazine

  [Refereed]


• Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence

  Taro Kishi, Tsuyoshi Kitajima, Kunihiro Kawashima, Tomo Okochi, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

  Mar. 2011, CURRENT NEUROPHARMACOLOGY, 9(1) (1), 129 - 132, English


• Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese.

  Takenori Okumura, Tomo Okochi, Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoko Kinoshita, Kunihiro Kawashima, Tomoko Tsunoka, Yasuhisa Fukuo, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Hiroshi Ujike, Nakao Iwata

  Mar. 2011, Current neuropharmacology, 9(1) (1), 155 - 9, English, International magazine

  [Refereed]


• No Association Between GRM3 and Japanese Methamphetamine-Induced Psychosis.

  Tomoko Tsunoka, Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Tomo Okochi, Takenori Okumura, Toshiya Inada, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

  Mar. 2011, Current neuropharmacology, 9(1) (1), 160 - 2, English, International magazine

  [Refereed]


• Quantitative Detection of µ Opioid Receptor: Western Blot Analyses Using µ Opioid Receptor Knockout Mice.

  Shinya Kasai, Hideko Yamamoto, Etsuko Kamegaya, George R Uhl, Ichiro Sora, Masahiko Watanabe, Kazutaka Ikeda

  Mar. 2011, Current neuropharmacology, 9(1) (1), 219 - 22, English, International magazine

  [Refereed]


• Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis.

  Hideaki Kobayashi, Hiroshi Ujike, Nakao Iwata, Toshiya Inada, Mitsuhiko Yamada, Yoshimoto Sekine, Naohisa Uchimura, Masaomi Iyo, Norio Ozaki, Masanari Itokawa, Ichiro Sora

  Mar. 2011, Current neuropharmacology, 9(1) (1), 176 - 82, English, International magazine

  [Refereed]


• Methylone and Monoamine Transporters: Correlation with Toxicity

  Chiharu Sogawa, Norio Sogawa, Kazumi Ohyama, Ruri Kikura-Hanajiri, Yukihiro Goda, Ichiro Sora, Shigeo Kitayama

  Mar. 2011, CURRENT NEUROPHARMACOLOGY, 9(1) (1), 58 - 62, English


• Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence.

  Taro Kishi, Tsuyoshi Kitajima, Kunihiro Kawashima, Tomo Okochi, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

  Mar. 2011, Current neuropharmacology, 9(1) (1), 129 - 32, English, International magazine

  [Refereed]


• Lack of association between prokineticin 2 gene and Japanese methamphetamine dependence.

  Taro Kishi, Tsuyoshi Kitajima, Tomoko Tsunoka, Takenori Okumura, Kunihiro Kawashima, Tomo Okochi, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

  Mar. 2011, Current neuropharmacology, 9(1) (1), 133 - 6, English, International magazine

  [Refereed]


• アルコールを含めた物質依存に対する病態解明及び心理社会的治療法の開発に関する研究 薬物依存症の機序・病態における個体要因に関する研究:NMDA受容体遺伝子,GRIN1,2A,2Bの検計

  高木学, 岡久祐子, 氏家寛, 氏家寛, 水木寛, 小高辰也, 元武俊, 近藤直樹, 成瀬暢也, 曽良一郎, 岩田仲生, 伊豫雅臣, 尾崎紀夫, 内富庸介

  2011, 精神・神経疾患研究開発費による研究報告集(2年度班・初年度班) 平成22年度


• NMDA受容体遺伝子サブユニットGRIN2B遺伝子(GRIN2B)多型と覚せい剤依存症の関連研究

  水木寛, 氏家寛, 氏家寛, 岡久祐子, 高木学, 児玉匡史, 元武俊, 元武俊, 近藤直樹, 近藤直樹, 成瀬暢也, 成瀬暢也, 曽良一郎, 曽良一郎, 岩田仲生, 岩田仲生, 伊豫雅臣, 伊豫雅臣, 尾崎紀夫, 尾崎紀夫, 内宮庸介

  2011, 日本生物学的精神医学会誌, 22(Supplement) (Supplement)


• Disorders and regulation of reward system

  Ichiro Sora, Kazutaka Ikeda

  2011, NEUROSCIENCE RESEARCH, 71, E16 - E17, English

  Summary international conference


• Methamphetamine-induced behavioral sensitization in 5-HT1B-KO mice

  Yuki Moriya, Kana Ishihara, Yoshiyuki Kasahara, Ichiro Sora

  2011, NEUROSCIENCE RESEARCH, 71, E397 - E397, English

  Summary international conference


• 薬物依存の再発防止に関する研究

  池田和隆, 西澤大輔, 大谷保和, 高松幸雄, 曽良一郎

  2011, 厚生労働科学研究費補助金 (医薬品・医療機器等レギュラトリーサイエンス総合研究推進事業), 乱用薬物による薬物依存の発症メカニズム・予防・診断及び治療法に関する研究, 平成22年度 総括研究報告書 (研究代表者: 鍋島俊隆), 90 - 99, Japanese


• 覚せい剤精神病の分子遺伝学的機序

  曽良一郎, 森屋由紀, 小林秀昭, 萩野洋子, 有銘預世布, 笠原好之, 糸川昌成, 岩田仲生, 稲田俊也, 山田光彦, 関根吉統, 内村直尚, 伊豫雅臣, 尾崎紀夫, 氏家寛, 池田和隆

  2011, 厚生労働科学研究費補助金 (医薬品・医療機器等レギュラトリーサイエンス総合研究推進事業), 乱用薬物による薬物依存の発症メカニズム・予防・診断及び治療法に関する研究, 平成22年度 総括研究報告書 (研究代表者: 鍋島俊隆), 68 - 76, Japanese


• 統合失調症動物モデルにおける神経回路の形成・発達の解析 (精神薬療研究年報)

  笠原好之, 有銘預世布, 福井麻美, 久保有美子, 曽良一郎

  2011, 精神薬療研究年報, (43) (43), 73 - 74


• 【脳の機能と統合失調症-新たな診断と治療への展望-II】 認知機能評価システムの構築 MATRICS-CCB-J、BACS-Jおよび社会機能測定法について (精神科治療学)

  住吉 太幹, 兼田 康宏, 住吉 チカ, 曽良 一郎

  2011, 精神科治療学, 26(12) (12), 1525 - 1531


• 【認知症学(上)-その解明と治療の最新知見-】 基礎編 ニューロトランスミッターと神経伝達機能 各論 カテコールアミン神経伝達 (日本臨床)

  曽良 一郎

  2011, 日本臨床, 69(増刊8 認知症学(上)) (増刊8 認知症学(上)), 224 - 227


• 【認知機能障害に対する治療をどう評価するか】 MATRICSコンセンサス認知機能評価バッテリー日本語版の開発への取り組み (日本神経精神薬理学雑誌)

  佐藤 拓, 曽良 一郎

  2011, 日本神経精神薬理学雑誌, 31(5月6日) (5月6日), 241 - 244


• 【モデル動物を用いた精神疾患のメカニズム研究;脳発達の視点から】 ドーパミン神経伝達過剰マウスモデルにおける神経発達 (日本神経精神薬理学雑誌)

  笠原 好之, 有銘 預世布, 久保 有美子, 福井 麻美, 曽良 一郎

  2011, 日本神経精神薬理学雑誌, 31(5月6日) (5月6日), 195 - 199


• フェンサイクリジンの作用におけるNMDA受容体チャネルGluN2Dサブユニットの役割 (日本アルコール・薬物医学会雑誌)

  萩野 洋子, 笠井 慎也, 山本 秀子, 曽良 一郎, 鍋島 俊隆, 三品 昌美, 池田 和隆

  2011, 日本アルコール・薬物医学会雑誌, 46(4) (4), 207 - 207


• ドロキシドパのAD/HDへの効果 (日本医事新報)

  曽良一郎

  2011, 日本医事新報, (4534) (4534), 99 - 100


• カテコールアミン神経伝達. 認知症学（上）その解明と治療の最新知見 (日本臨床)

  曽良一郎

  2011, 日本臨床, 69(8) (8), 224 - 227


• JSNP東日本大震災対策WG 宮城県仙台市-石巻 視察報告書 (日本神経精神薬理学雑誌)

  山田清文, 曽良一郎, 池田和隆

  2011, 日本神経精神薬理学雑誌, 31(3) (3), 141 - 145


• 【脳の機能と統合失調症-新たな診断と治療への展望-II】 認知機能評価システムの構築 MATRICS-CCB-J、BACS-Jおよび社会機能測定法について (精神科治療学)

  住吉 太幹, 兼田 康宏, 住吉 チカ, 曽良 一郎

  2011, 精神科治療学, 26(12) (12), 1525 - 1531


• 【モデル動物を用いた精神疾患のメカニズム研究;脳発達の視点から】 ドーパミン神経伝達過剰マウスモデルにおける神経発達 (日本神経精神薬理学雑誌)

  笠原 好之, 有銘 預世布, 久保 有美子, 福井 麻美, 曽良 一郎

  2011, 日本神経精神薬理学雑誌, 31(5月6日) (5月6日), 195 - 199


• 【認知機能障害に対する治療をどう評価するか】 MATRICSコンセンサス認知機能評価バッテリー日本語版の開発への取り組み (日本神経精神薬理学雑誌)

  佐藤 拓, 曽良 一郎

  2011, 日本神経精神薬理学雑誌, 31(5月6日) (5月6日), 241 - 244


• 【認知症学(上)-その解明と治療の最新知見-】 基礎編 ニューロトランスミッターと神経伝達機能 各論 カテコールアミン神経伝達 (日本臨床)

  曽良 一郎

  2011, 日本臨床, 69(増刊8 認知症学(上)) (増刊8 認知症学(上)), 224 - 227


• フェンサイクリジンの作用におけるNMDA受容体チャネルGluN2Dサブユニットの役割 (日本アルコール・薬物医学会雑誌)

  萩野 洋子, 笠井 慎也, 山本 秀子, 曽良 一郎, 鍋島 俊隆, 三品 昌美, 池田 和隆

  2011, 日本アルコール・薬物医学会雑誌, 46(4) (4), 207 - 207


• カテコールアミン神経伝達. 認知症学（上）その解明と治療の最新知見 (日本臨床)

  曽良一郎

  2011, 日本臨床, 69(8) (8), 224 - 227


• JSNP東日本大震災対策WG 宮城県仙台市-石巻 視察報告書 (日本神経精神薬理学雑誌)

  山田清文, 曽良一郎, 池田和隆

  2011, 日本神経精神薬理学雑誌, 31(3) (3), 141 - 145


• Association analysis of the adenosine A1 receptor gene polymorphisms in patients with methamphetamine dependence/psychosis

  Hideaki Kobayashi, Hiroshi Ujike, Nakao Iwata, Toshiya Inada, Mitsuhiko Yamada, Yoshimoto Sekine, Naohisa Uchimura, Masaomi Iyo, Norio Ozaki, Masanari Itokawa, Ichiro Sora

  2011, Current Neuropharmacology, 9(1) (1), 137 - 142, English, International magazine


• ドロキシドパのAD/HDへの効果 (日本医事新報)

  曽良一郎

  2011, 日本医事新報, (4534) (4534), 99 - 100


• 統合失調症動物モデルにおける神経回路の形成・発達の解析 (精神薬療研究年報)

  笠原好之, 有銘預世布, 福井麻美, 久保有美子, 曽良一郎

  2011, 精神薬療研究年報, (43) (43), 73 - 74


• ラモトリギン投与によるヒトニューロン由来SK-N-SH細胞における包括的遺伝子発現の検討(Examination of the comprehensive gene expression in the SK-N-SH cell by the LTG dosage)

  田邊 陽一郎, 愈 志前, 小野 千晶, 羽藤 愛, 松岡 洋夫, 曽良 一郎, 富田 博秋

  日本臨床精神神経薬理学会・日本神経精神薬理学会, Sep. 2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 124 - 124, English


• ラモトリギン投与によるヒトニューロン由来SK-N-SH細胞における包括的遺伝子発現の検討(Examination of the comprehensive gene expression in the SK-N-SH cell by the LTG dosage)

  田邊 陽一郎, 愈 志前, 小野 千晶, 羽藤 愛, 松岡 洋夫, 曽良 一郎, 富田 博秋

  日本臨床精神神経薬理学会・日本神経精神薬理学会, Sep. 2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 124 - 124, English


• 気分安定薬のアストロサイトにおける軸索誘導タンパク発現の誘導 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  兪 志前, 小野 千晶, 田邊 陽一郎, 小松 浩, 松岡 洋夫, 曽良 一郎, 富田 博秋

  日本臨床精神神経薬理学会・日本神経精神薬理学会, Sep. 2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 124 - 124, Japanese


• 統合失調症罹患者のTh1およびTh2細胞のマイクロアレイ遺伝子発現プロファイリング (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  小野 千晶, 兪 志前, 田邊 陽一郎, 小松 浩, 松岡 洋夫, 曽良 一郎, 石井 直人, 富田 博秋

  日本臨床精神神経薬理学会・日本神経精神薬理学会, Sep. 2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 151 - 151, Japanese


• 成体マウス海馬の神経新生及び機能における脂肪酸結合タンパク質FABPの役割(The role of FABPs in postnatal hippocampal neurogenesis and function)

  松股 美穂, 前川 素子, 有銘 預世布, 大和田 祐二, 曽良 一郎, 吉川 武男, 大隅 典子

  日本神経化学会, Aug. 2010, 神経化学, 49(2-3) (2-3), 566 - 566, English


• 双極性障害治療薬のアストロサイトにおける遺伝子発現変化の包括的検討(Mood stabilizers-mediated gene expression in human astrocytes)

  兪 志前, 小野 千晶, 田邊 陽一郎, 曽良 一郎, 富田 博秋

  日本神経化学会, Aug. 2010, 神経化学, 49(2-3) (2-3), 676 - 676, English


• 脳内報酬系を担うドーパミン神経伝達 (ADHD薬物療法の新時代--コンサータとストラテラ) -- (コンサータに関する知識と経験)

  曽良 一郎, 久保 有美子, 有銘 預世布

  至文堂, Apr. 2010, 現代のエスプリ, (513) (513), 124 - 133, Japanese


• 稀な遺伝子変異症例の分子基盤に基づく統合失調症の診断・治療法の開発

  新井 誠, 市川 智恵, 新井 麻友美, 小幡 菜々子, 野原 泉, 西田 淳志, 湯澤 公子, 大西 哲生, 豊田 倫子, 曽良 一郎, 氏家 寛, 松下 正明, 有波 忠雄, 尾崎 紀夫, 橋本 亮太, 笠井 清登, 橋本 謙二, 森 則夫, 岩田 仲生, 岡崎 祐士, 宮田 敏男, 吉川 武男, 糸川 昌成

  (公財)先進医薬研究振興財団, Mar. 2010, 精神薬療研究年報, (42) (42), 75 - 76, Japanese


• 【アトモキセチン 基礎と臨床】 アトモキセチンの薬理作用機序 (精神科)

  有銘預世布, 福井麻美, 笠原好之, 曽良一郎

  科学評論社, Mar. 2010, 精神科, 16(3) (3), 223 - 226, Japanese

  Introduction scientific journal


• メタンフェタミン前処理がD5ドーパミン受容体欠損マウスに及ぼす逆説的な効果

  林崎誠二, 伊東由美, 高田昌彦, 本多芳子, 児玉亨, 有銘預世布, 曽良一郎, 平井志伸, 岡戸晴生

  Mar. 2010, CREST研究領域「脳の機能発達と学習メカニズムの解明」. 第7回領域内研究報告会 (2010/03, 大阪府豊中市), Japanese

  [Refereed]


• 薬物依存症および中毒性精神病に対する治療法の開発・普及と診療の普及に関する研究 覚せい剤依存症の遺伝子リスクファクターに関する研究

  氏家寛, 岡久祐子, 小高辰也, 高木学, 児玉匡史, 近藤直樹, 元武俊, 稲田俊也, 山田光彦, 曽良一郎, 岩田仲生, 伊豫雅臣, 尾崎紀夫

  2010, 薬物依存症および中毒性精神病に対する治療法の開発・普及と診療の普及に関する研究 平成19-21年度 総括研究報告書 分担研究報告書


• 乱用薬物による神経毒性・依存症に対する診断・予防及び治療法に関する研究 薬物依存の新たな治療開発のための候補分子の探索 NMDA受容体遺伝子,GRIN1,2A,2Bの覚せい剤精神病での解析

  氏家寛, 氏家寛, 岡久祐子, 小高辰也, 高木学, 近藤直樹, 元武俊, 稲田俊也, 山田光彦, 曽良一郎, 岩田仲生, 伊豫雅臣, 尾崎紀夫

  2010, 乱用薬物による神経毒性・依存症に対する診断・予防及び治療法に関する研究 平成21年度 総括研究報告書 平成19-21年度3年間のまとめ・総合研究報告書


• 乱用薬物による神経毒性・依存症に対する診断・予防及び治療法に関する研究 薬物依存の新たな治療開発のための候補分子の探索

  氏家寛, 岸本真希子, 本橋靖子, 岡久祐子, 小高辰也, 高木学, 近藤直樹, 元武俊, 稲田俊也, 原野陸正, 内村直尚, 小宮山徳太郎, 堀達, 山田光彦, 関根吉統, 曽良一郎, 岩田仲生, 伊豫雅臣, 尾崎紀夫, 黒田重利

  2010, 乱用薬物による神経毒性・依存症に対する診断・予防及び治療法に関する研究 平成21年度 総括研究報告書 平成19-21年度3年間のまとめ・総合研究報告書


• How can schizophrenic cognitive dysfunction be integrated with experimental data?

  Ichiro Sora

  2010, NEUROSCIENCE RESEARCH, 68, E49 - E49, English

  Summary international conference


• メタンフェタミン依存へのセロトニン1B、アデノシンA2受容体の関与

  曽良一郎, 小林秀昭, 石原佳奈, 有銘預世布, 萩野洋子, 池田和隆, 糸川昌成, 岩田仲生, 稲田俊也, 山田光彦, 関根吉統, 内村直尚, 伊豫雅臣, 尾崎紀夫, 氏家寛, 笠原好之

  2010, 厚生労働科学研究費補助金 (医薬品・医療機器等レギュラトリーサイエンス総合研究推進事業), 乱用薬物による神経毒性・依存症に対する診断・予防及び治療法に関する研究, 平成21年度総括研究報告書 (主任研究者: 鍋島俊隆), 56 - 66, Japanese


• 薬物依存における薬物再使用危険度評価尺度の開発と候補治療薬の探索

  池田和隆, 高松幸雄, 大谷保和, 原口彩子, 西澤大輔, 笠井慎也, 小林徹, 妹尾栄一, 堀達, 氏家寛, 曽良一郎

  2010, 厚生労働科学研究費補助金 (医薬品・医療機器等レギュラトリーサイエンス総合研究推進事業), 乱用薬物による神経毒性・依存症に対する診断・予防及び治療法に関する研究, 平成21年度総括研究報告書 (主任研究者: 鍋島俊隆), 78 - 89, Japanese


• 依存性薬物の精神神経毒性と標的分子への作用機序の解明

  曽良一郎, 笠原好之, 小林秀昭, 李炳錦, 石原佳奈, 猪狩もえ, 萩野洋子, SHEN Haowei, 山本秀子, 有銘預世布, 十川千春, 十川紀夫, 糸川昌成, 岩田仲生, 稲田俊也, 山田光彦, 関根吉統, 内村直尚, 伊豫雅臣, 尾崎紀夫, 氏家寛, 北山滋雄, 池田和隆

  2010, 厚生労働科学研究費補助金 (医薬品・医療機器等レギュラトリーサイエンス総合研究推進事業), 乱用薬物による神経毒性・依存症に対する診断・予防及び治療法に関する研究, 平成19年度～平成21年度3年間のまとめ・総合研究報告書 (主任研究者: 鍋島俊隆), 190 - 204, Japanese


• 幼若期DAT遺伝子欠損マウスの多動とメチルフェニデートによる多動亢進 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  高松 幸雄, 佐藤 敦志, 曽良 一郎, 池田 和隆

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 191 - 191


• 薬物依存の脆弱性要因. (実験医学)

  曽良一郎

  2010, 実験医学, 28(5) (5), 38 - 42


• 脳内報酬系を担うドーパミン神経伝達. (現代のエスプリ )

  曽良一郎, 久保有美子, 有銘預世布, 笠原好之, 佐藤拓

  2010, 現代のエスプリ, 4, 124 - 133


• 統合失調症罹患者のTh1およびTh2細胞のマイクロアレイ遺伝子発現プロファイリング (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  小野 千晶, 兪 志前, 田邊 陽一郎, 小松 浩, 松岡 洋夫, 曽良 一郎, 石井 直人, 富田 博秋

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 151 - 151


• 統合失調症モデルマウスにおけるノルエピネフリントランスポーター阻害薬の異なる効果 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  有銘 預世布, 曽良 一郎

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 167 - 167


• 統合失調症と生活習慣 (Schizophrenia Frontier)

  曽良一郎

  2010, Schizophrenia Frontier, 69 - 70


• 双極性障害治療薬のアストロサイトにおける遺伝子発現変化の包括的検討 (神経化学)

  兪 志前, 小野 千晶, 田邊 陽一郎, 曽良 一郎, 富田 博秋

  2010, 神経化学, 49(2月3日) (2月3日), 676 - 676


• 神経科学の素朴な疑問 痛みがあると薬物依存になりにくいというのは本当ですか? (Clinical Neuroscience)

  曽良一郎, 佐々木一益

  2010, Clinical Neuroscience, 28(5) (5), 581 - 581


• 若齢AD/HD動物モデルにおける治療薬反応性 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  久保 有美子, 有銘 預世布, 笠原 好之, 曽良 一郎

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 192 - 192


• 次世代の鎮痛と精神薬理 痛み・情動におけるμオピオイド受容体の役割 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  井手 聡一郎, 南 雅文, 佐藤 公道, 曽良 一郎, 池田 和隆

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 63 - 63


• 気分安定薬のアストロサイトにおける軸索誘導タンパク発現の誘導 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  兪 志前, 小野 千晶, 田邊 陽一郎, 小松 浩, 松岡 洋夫, 曽良 一郎, 富田 博秋

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 124 - 124


• 【臨床開発の最近の動向】 MATRICSコンセンサス認知機能評価バッテリーの開発 統合失調症治療への導入を目指して (臨床精神薬理)

  佐藤拓, 兼田康宏, 住吉チカ, 住吉太幹, 曽良一郎

  2010, 臨床精神薬理, 13(2) (2), 289 - 296


• 【薬物依存症 薬物依存症のトレンド】 薬物依存症の臨床各論 最新動向 コカイン依存研究の動向 (日本臨床)

  笠原好之, 有銘預世布, 福井麻美, 内海修, 曽良一郎

  2010, 日本臨床, 68(8) (8), 1479 - 1485


• 【脳神経系の情報伝達と疾患 さまざまなシグナル伝達因子の異常が引き起こす精神疾患・発達障害・神経変性疾患のメカニズム】 神経回路・システムの障害 薬物依存の脆弱性要因 (実験医学)

  曽良一郎

  2010, 実験医学, 28(5) (5), 674 - 678


• 【精神疾患の遺伝子は、本当にみつかったのか?】 メタンフェタミン依存 (分子精神医学)

  小林秀昭, 曽良一郎

  2010, 分子精神医学, 10(1) (1), 17 - 26


• 【シナプス 形態・機能・病態】 シナプスの病態 薬物依存症 (Clinical Neuroscience)

  曽良一郎, 内海修

  2010, Clinical Neuroscience, 28(8) (8), 928 - 930


• モデル動物を用いた精神疾患のメカニズム研究 脳発達の視点から ドーパミン神経伝達過剰マウスモデルにおける神経発達 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  笠原 好之, 有銘 預世布, 久保 有美子, 福井 麻美, 曽良 一郎

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 52 - 52


• メタンフェタミン処理による初代培養脳幹由来神経細胞のμ-オピオイド受容体の発現低下 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  山本 秀子, 亀ヶ谷 悦子, 澤田 和可子, 山本 敏文, 韓 文華, 曽良 一郎, 柳川 右千夫, 池田 和隆

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 167 - 167


• ドーパミントランスポーターノックアウトマウスにおける前頭葉の神経可塑性と認知機能障害 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  有銘 預世布, 笠原 好之, 曽良 一郎

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 152 - 152


• アリピプラゾールがドーパミントランスポーター欠損マウスの多動および協調運動障害に与える効果 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  佐藤 敦志, 高松 幸雄, 曽良 一郎, 水口 雅, 池田 和隆

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 191 - 191


• Combination of cell culture assays and knockout mouse analyses for the study of opioid partial agonism. (Methods Mol Biol)

  Ide Soichiro, Minami Masabumi, Sora Ichiro, Ikeda Kazutaka

  2010, Methods Mol Biol, 617, 363 - 374


• [Trend in the study of cocaine addiction]. (Nihon Rinsho)

  Kasahara Yoshiyuki, Arime Yosefu, Fukui Asami, Uchiumi Osamu, Sora Ichiro

  2010, Nihon Rinsho, 68(8) (8), 1479 - 1485


• モデル動物を用いた精神疾患のメカニズム研究 脳発達の視点から ドーパミン神経伝達過剰マウスモデルにおける神経発達 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  笠原 好之, 有銘 預世布, 久保 有美子, 福井 麻美, 曽良 一郎

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 52 - 52


• 次世代の鎮痛と精神薬理 痛み・情動におけるμオピオイド受容体の役割 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  井手 聡一郎, 南 雅文, 佐藤 公道, 曽良 一郎, 池田 和隆

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 63 - 63


• ドーパミントランスポーターノックアウトマウスにおける前頭葉の神経可塑性と認知機能障害 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  有銘 預世布, 笠原 好之, 曽良 一郎

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 152 - 152


• 統合失調症モデルマウスにおけるノルエピネフリントランスポーター阻害薬の異なる効果 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  有銘 預世布, 曽良 一郎

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 167 - 167


• メタンフェタミン処理による初代培養脳幹由来神経細胞のμ-オピオイド受容体の発現低下 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  山本 秀子, 亀ヶ谷 悦子, 澤田 和可子, 山本 敏文, 韓 文華, 曽良 一郎, 柳川 右千夫, 池田 和隆

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 167 - 167


• アリピプラゾールがドーパミントランスポーター欠損マウスの多動および協調運動障害に与える効果 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  佐藤 敦志, 高松 幸雄, 曽良 一郎, 水口 雅, 池田 和隆

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 191 - 191


• 幼若期DAT遺伝子欠損マウスの多動とメチルフェニデートによる多動亢進 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  高松 幸雄, 佐藤 敦志, 曽良 一郎, 池田 和隆

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 191 - 191


• 若齢AD/HD動物モデルにおける治療薬反応性 (日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集)

  久保 有美子, 有銘 預世布, 笠原 好之, 曽良 一郎

  2010, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 20回・40回, 192 - 192


• [Trend in the study of cocaine addiction]. (Nihon Rinsho)

  Kasahara Yoshiyuki, Arime Yosefu, Fukui Asami, Uchiumi Osamu, Sora Ichiro

  Psychostimulant drugs including cocaine increase extracellular levels of monoamines by blocking the neuronal plasma membrane transporters. Increased extracellular dopamine levels in mesocorticolimbic dopamine systems have been postulated to mediate the rewarding effects of cocaine. Studies in genetically modified mice models, particularly knockout mice have contributed a great deal to our understanding of the mechanisms underlying psychostimulant actions. Phenotypic analysis of genetically modified mice models has been instrumental in identifying the role of specific molecular targets of cocaine. In this article, we summarize studies that have reported the effects of cocaine using genetically modified mice especially gene knockouts of the monoamine transporters and receptors.

  2010, Nihon Rinsho, 68(8) (8), 1479 - 1485, Japanese, Domestic magazine


• 【シナプス 形態・機能・病態】 シナプスの病態 薬物依存症 (Clinical Neuroscience)

  曽良一郎, 内海修

  2010, Clinical Neuroscience, 28(8) (8), 928 - 930


• 【薬物依存症 薬物依存症のトレンド】 薬物依存症の臨床各論 最新動向 コカイン依存研究の動向 (日本臨床)

  笠原好之, 有銘預世布, 福井麻美, 内海修, 曽良一郎

  2010, 日本臨床, 68(8) (8), 1479 - 1485


• 神経科学の素朴な疑問 痛みがあると薬物依存になりにくいというのは本当ですか? (Clinical Neuroscience)

  曽良一郎, 佐々木一益

  2010, Clinical Neuroscience, 28(5) (5), 581 - 581


• 薬物依存の脆弱性要因. (実験医学)

  曽良一郎

  2010, 実験医学, 28(5) (5), 38 - 42


• 脳内報酬系を担うドーパミン神経伝達. (現代のエスプリ )

  曽良一郎, 久保有美子, 有銘預世布, 笠原好之, 佐藤拓

  2010, 現代のエスプリ, 4, 124 - 133


• Combination of cell culture assays and knockout mouse analyses for the study of opioid partial agonism. (Methods Mol Biol)

  Ide Soichiro, Minami Masabumi, Sora Ichiro, Ikeda Kazutaka

  2010, Methods Mol Biol, 617, 363 - 374


• 【脳神経系の情報伝達と疾患 さまざまなシグナル伝達因子の異常が引き起こす精神疾患・発達障害・神経変性疾患のメカニズム】 神経回路・システムの障害 薬物依存の脆弱性要因 (実験医学)

  曽良一郎

  2010, 実験医学, 28(5) (5), 674 - 678


• 統合失調症と生活習慣 (Schizophrenia Frontier)

  曽良一郎

  2010, Schizophrenia Frontier, 69 - 70


• 【臨床開発の最近の動向】 MATRICSコンセンサス認知機能評価バッテリーの開発 統合失調症治療への導入を目指して (臨床精神薬理)

  佐藤拓, 兼田康宏, 住吉チカ, 住吉太幹, 曽良一郎

  2010, 臨床精神薬理, 13(2) (2), 289 - 296


• 【精神疾患の遺伝子は、本当にみつかったのか?】 メタンフェタミン依存 (分子精神医学)

  小林秀昭, 曽良一郎

  先端医学社, 2010, 分子精神医学, 10(1) (1), 17 - 26, Japanese


• D5ドーパミン受容体のドーパミントランスポーター機能への関与

  林崎誠二, 平井志伸, 伊東由美, 本多芳子, 有銘預世布, 曽良一郎, 児玉亨, 岡戸晴生, 高田昌彦

  Sep. 2009, 第32回日本神経科学大会 (2009/09, 名古屋)．, Japanese

  [Refereed]


• 気分安定薬奏功機序解明のための包括的遺伝子発現解析

  富田 博秋, 田中 千晶, 兪 志前, 小松 浩, 木村 好, 曽良 一郎, ヘレン・B.・キム, ウィリアム・E.・バニー

  気分安定薬4剤(リチウム、バルプロ酸、カルバマゼピン、ラモトリジン)を、ヒト脳内の3種の細胞(神経細胞、アストロサイト、オリゴデンドロサイト)に由来する各培養細胞に投与し、遺伝子発現プロファイルへの影響をマイクロアレイ解析により検討した。その結果、遺伝子発現プロファイルに対してリチウムとバルプロ酸は相互に比較的類似した影響を及ぼし、カルバマゼピンとラモトリジンは相互に比較的類似した影響を及ぼした。遺伝子発現プロファイルへの影響を3種の細胞ごとにみると、バルプロ酸は全ての細胞に比較的共通した発現変化をもたらしたのに対し、他の3剤による発現変化は細胞ごとに大きく異なった。

  (公財)臨床薬理研究振興財団, Jul. 2009, 臨床薬理の進歩, 30(30) (30), 52 - 59, Japanese


• 気分安定薬奏功機序解明のための包括的遺伝子発現解析. ( 臨床薬理の進歩)

  富田博秋, 田中千晶, 兪志前, 小松浩, 木村好, 曽良一郎, ヘレンB.キム, ウィリアムE.バニー

  気分安定薬4剤(リチウム、バルプロ酸、カルバマゼピン、ラモトリジン)を、ヒト脳内の3種の細胞(神経細胞、アストロサイト、オリゴデンドロサイト)に由来する各培養細胞に投与し、遺伝子発現プロファイルへの影響をマイクロアレイ解析により検討した。その結果、遺伝子発現プロファイルに対してリチウムとバルプロ酸は相互に比較的類似した影響を及ぼし、カルバマゼピンとラモトリジンは相互に比較的類似した影響を及ぼした。遺伝子発現プロファイルへの影響を3種の細胞ごとにみると、バルプロ酸は全ての細胞に比較的共通した発現変化をもたらしたのに対し、他の3剤による発現変化は細胞ごとに大きく異なった。

  (公財)臨床薬理研究振興財団, Jul. 2009, 臨床薬理の進歩, 30(30) (30), 52 - 59, Japanese


• 覚せい剤精神病におけるグルタミン酸神経伝達関連遺伝子解析

  氏家 寛, 小高 辰也, 岸本 真希子, 岡久 祐子, 高木 学, 児玉 匡史, 稲田 俊也, 山田 光彦, 内村 直尚, 岩田 仲生, 曽良 一郎, 伊豫 雅臣, 尾崎 紀夫, 黒田 重利

  (公財)先進医薬研究振興財団, Mar. 2009, 精神薬療研究年報, (41) (41), 25 - 26, Japanese


• カンナビノイドCB1受容体およびCB2受容体遺伝子多型と覚せい剤依存症の関連研究

  岡久祐子, 氏家寛, 氏家寛, 児玉匡史, 高木学, 小高辰也, 中田謙二, 稲田俊也, 内村直尚, 山田光彦, 岩田仲生, 伊豫雅臣, 曽良一郎, 尾崎紀夫, 黒田重利

  2009, 日本生物学的精神医学会プログラム・講演抄録, 31st


• 乱用薬物による神経毒性・依存症に対する診断・予防及び治療法に関する研究 薬物依存の新たな治療開発のための候補分子の探索 D体アミノ酸酸化酵素活性因子およびセリンラマーゼ遺伝子の解析

  氏家寛, 氏家寛, 岡久祐子, 小高辰也, 高木学, 稲田俊也, 山田光彦, 内村直尚, 曽良一郎, 岩田仲生, 伊豫雅臣, 尾崎紀夫, 黒田重利

  2009, 乱用薬物による神経毒性・依存症に対する診断・予防及び治療法に関する研究 平成20年度 研究報告書


• 気分安定薬のアストロサイトにおける遺伝子発現変化の包括的検討

  兪志前, 田中千晶, 小松浩, 高橋怜史, 木村好, 曽良一郎, 富田博秋

  2009, 日本生物学的精神医学会プログラム・講演抄録, 31st


• 気分安定薬リチウムの樹状細胞における遺伝子発現変化の包括的検討

  兪志前, 小野千晶, 田邊陽一郎, 田邊陽一郎, 小松浩, 小松浩, 木村好, 羽藤愛, 松岡洋夫, 曽良一郎, 富田博秋

  2009, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 19th-39th


• ラモトリギン投与によるヒト脳由来細胞における包括的遺伝子発現の解析

  田邊陽一郎, 田邊陽一郎, 田邊陽一郎, 田中千晶, 愈志前, 小松浩, 小松浩, 木村好, 羽藤愛, 松岡洋夫, 曽良一郎, 富田博秋

  2009, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 19th-39th


• 薬物依存における薬物再使用危険度評価尺度の開発と候補治療薬の探索

  池田和隆, 大谷保和, 原口彩子, 西澤大輔, 小林大輔, 笠井慎也, 高松幸雄, 林田眞和, 妹尾栄一, 曽良一郎

  2009, 厚生労働科学研究費補助金 (医薬品・医療機器等レギュラトリーサイエンス総合研究推進事業), 乱用薬物による神経毒性・依存症に対する診断・予防及び治療法に関する研究, 平成20年度研究報告書 (主任研究者: 鍋島俊隆), 336 - 346, Japanese


• メタンフェタミン行動感作形成におけるセロトニン神経伝達の関与

  曽良一郎, 猪狩もえ, 萩野洋子, SHEN Haowei, 石原佳奈, 山本秀子, 有銘預世布, 笠原好之, 池田和隆

  2009, 厚生労働科学研究費補助金 (医薬品・医療機器等レギュラトリーサイエンス総合研究推進事業), 乱用薬物による神経毒性・依存症に対する診断・予防及び治療法に関する研究, 平成20年度研究報告書 (主任研究者: 鍋島俊隆), 216 - 224, Japanese


• 子供の毒性学 発達期における依存性物質の中枢作用と注意欠如多動性障害 ドパミントランスポーター欠損マウスの知見を中心に (The Journal of Toxicological Sciences)

  池田 和隆, 高松 幸雄, 曽良 一郎

  2009, The Journal of Toxicological Sciences, 34(Suppl.) (Suppl.), S28-S28


• 遺伝子多型とオピオイドの副作用?特集：痛みと遺伝子多型? ( 麻酔)

  曽良一郎, 小松浩, 猪狩もえ, 井手総一郎, 池田和隆, 下山直人

  2009, 麻酔, 58(9) (9), 1109 - 1111


• 【発達障害の新たな遺伝子】 AD/HDの遺伝要因解明の現状 (分子精神医学)

  曽良一郎, 笠原好之, 内海修, 久保有美子, 富田博秋, 池田和隆

  2009, 分子精神医学, 9(3) (3), 262 - 267


• メチルフェニデートの精神神経系に及ぼす影響 (日本神経精神薬理学雑誌)

  池田和隆, 高松幸雄, 萩野洋子, 曽良一郎

  2009, 日本神経精神薬理学雑誌, 29(3) (3), 121 - 123


• Atomoxetineのプロフィールと薬理作用 ?特集 Atomoxetineの導入でAD/HD治療はどう変わるか？? (臨床精神薬理)

  曽良一郎, 福井麻美, 池田和隆, 笠原好之

  2009, 臨床精神薬理, 12(9) (9), 1951 - 1956


• Atomoxetineのプロフィールと薬理作用 ?特集 Atomoxetineの導入でAD/HD治療はどう変わるか？? (臨床精神薬理)

  曽良一郎, 福井麻美, 池田和隆, 笠原好之

  2009, 臨床精神薬理, 12(9) (9), 1951 - 1956


• 遺伝子多型とオピオイドの副作用?特集：痛みと遺伝子多型? ( 麻酔)

  曽良一郎, 小松浩, 猪狩もえ, 井手総一郎, 池田和隆, 下山直人

  克誠堂出版(株), 2009, 麻酔, 58(9) (9), 1109 - 1111, Japanese


• 【発達障害の新たな遺伝子】 AD/HDの遺伝要因解明の現状 (分子精神医学)

  曽良一郎, 笠原好之, 内海修, 久保有美子, 富田博秋, 池田和隆

  2009, 分子精神医学, 9(3) (3), 262 - 267


• 子供の毒性学 発達期における依存性物質の中枢作用と注意欠如多動性障害 ドパミントランスポーター欠損マウスの知見を中心に (The Journal of Toxicological Sciences)

  池田 和隆, 高松 幸雄, 曽良 一郎

  2009, The Journal of Toxicological Sciences, 34(Suppl.) (Suppl.), S28-S28


• メチルフェニデートの精神神経系に及ぼす影響 (日本神経精神薬理学雑誌)

  池田和隆, 高松幸雄, 萩野洋子, 曽良一郎

  2009, 日本神経精神薬理学雑誌, 29(3) (3), 121 - 123


• 線条体神経細胞におけるTrkB受容体を介したドーパミンD1受容体誘発シグナル伝達(Dopamine D1 receptor-induced signaling through TrkB receptors in striatal neurons)

  岩倉 百合子, 那波 宏之, 曽良 一郎, チャオ V.・モーゼス

  (一社)日本神経化学会, Aug. 2008, 神経化学, 47(2-3) (2-3), 230 - 230, English


• 日本人における覚せい剤精神障害とグルタチオン関連遺伝子多型の相関研究

  橋本 佐, 宮武 良輔, 伊豫 雅臣, 橋本 謙二, 関根 吉統, 稲田 俊也, 尾崎 紀夫, 岩田 仲生, 原野 睦生, 小宮山 徳太郎, 山田 光彦, 曽良 一郎, 氏家 寛

  日本アルコール・アディクション医学会, Aug. 2008, 日本アルコール・薬物医学会雑誌, 43(4) (4), 392 - 393, Japanese


• 日本人のNRG1遺伝子と覚醒剤使用障害は関連がなかった(No association between NRG1 and methamphetamine use disorder in the Japanese population)

  大河内 智, 岸 太郎, 池田 匡志, 北島 剛司, 木下 葉子, 川島 邦裕, 奥村 武則, 角鹿 智子, 稲田 俊哉, 山田 光彦, 内山 直尚, 伊豫 雅臣, 曽良 一郎, 尾崎 紀夫, 氏家 寛, 岩田 仲生

  日本神経化学会, Aug. 2008, 神経化学, 47(2-3) (2-3), 261 - 261, English


• ATP受容体サブタイプP2X₇遺伝子多型と疼痛感受性との関連解析

  井手聡一郎, 曽良一郎, 池田和隆

  19 Jul. 2008, Pain Res, 23(2) (2), 89, Japanese


• Genome-wide association for methamphetamine dependence: Convergent results from 2 samples

  George R. Uhl, Tomas Drgon, Qing-Rong Liu, Catherine Johnson, Donna Walther, Tokutaro Komiyama, Mutsuo Harano, Yoshimoto Sekine, Toshiya Inada, Norio Ozaki, Masaomi Iyo, Nakao Iwata, Mitsuhiko Yamada, Ichiro Sora, Chih-Ken Chen, Hsing-Cheng Liu, Hiroshi Ujike, Shih-Ku Lin

  Mar. 2008, Archives of General Psychiatry, 65(3) (3), 345 - 385, English, International magazine


• リチウム投与後の神経細胞のマイクロアレイ発現プロファイルの経時的変化

  高橋怜史, 田中千晶, YU Zhiqian, 木村好, 曽良一郎, 富田博秋

  2008, 生化学


• G72遺伝子と覚せい剤精神病との関連

  小高辰也, 氏家寛, 氏家寛, 岡久祐子, 高木学, 中田謙二, 稲田俊也, 山田光彦, 内村直尚, 岩田仲生, 曽良一郎, 伊豫雅臣, 尾崎紀夫, 黒田重利

  2008, 日本生物学的精神医学会プログラム・講演抄録, 30th


• RGS9遺伝子多型と統合失調症および覚せい剤依存症の関連研究

  岡久祐子, 氏家寛, 氏家寛, 小高辰也, 高木学, 中田謙二, 稲田俊也, 稲田俊也, 内村直尚, 内村直尚, 山田光彦, 山田光彦, 岩田仲生, 岩田仲生, 伊豫雅臣, 伊豫雅臣, 曽良一郎, 曽良一郎, 尾崎紀夫, 尾崎紀夫, 黒田重利

  2008, 日本生物学的精神医学会プログラム・講演抄録, 30th


• GDNF遺伝子とメタンフェタミン使用障害との関連解析

  臼井比奈子, 吉村智子, 吉見陽, 高橋長秀, 齋藤真一, 齋藤真一, ALEKSIC Branko, 石原良子, 氏家寛, 氏家寛, 稲田俊也, 稲田俊也, 山田光彦, 山田光彦, 内村直尚, 内村直尚, 岩田仲生, 岩田仲生, 曽良一郎, 曽良一郎, 伊豫雅臣, 伊豫雅臣, 尾崎紀夫, 尾崎紀夫

  2008, 日本生物学的精神医学会プログラム・講演抄録, 30th


• 気分調整薬がヒト神経由来細胞およびグリア由来細胞の各BDNF転写物バリアント発現量に及ぼす影響の検討

  小松浩, 田中千晶, 兪志前, 木村好, 高橋さとし, 曽良一郎, 松岡洋夫, 富田博秋

  2008, 日本生物学的精神医学会プログラム・講演抄録, 30th


• 薬物依存における薬物再使用危険度評価尺度の開発と候補治療薬の探索

  池田和隆, 大谷保和, 高松幸雄, 原口彩子, 萩野洋子, 山本秀子, 笠井慎也, 渡部崇, 妹尾栄一, 曽良一郎

  2008, 厚生労働科学研究費補助金 (医薬品・医療機器等レギュラトリーサイエンス総合研究推進事業), 乱用薬物による神経毒性・依存症に対する診断・予防及び治療法に関する研究, 平成19年度総括研究報告書 (主任研究者: 鍋島俊隆), 78 - 87, Japanese


• 疼痛治療個人差の遺伝子メカニズムに関する研究

  曽良一郎, 小松浩, 阿部裕美, 中野友美, 猪狩もえ, 長島誠, 田上惠, 福田謙一, 大谷保和, 笠井慎也, 井手聡一郎, 井手聡一郎, 林田眞和, 池田和隆

  2008, 厚生労働科学研究費補助金 (創薬基盤推進研究事業), 遺伝子多型検査によるテーラーメイド疼痛治療法の開発, 平成19年度総括研究報告書 (主任研究者: 池田和隆), 20 - 30, Japanese


• 疼痛治療個人差の遺伝子メカニズムに関する研究

  曽良一郎, 小松浩, 阿部裕美, 中野友美, 猪狩もえ, 長島誠, 田上惠, 福田謙一, 大谷保和, 笠井慎也, 林田眞和, 村上敏文, 高橋秀徳, 井手聡一郎, 下山直人, 池田和隆

  2008, 厚生労働科学研究費補助金 (創薬基盤推進研究事業), 遺伝子多型検査によるテーラーメイド疼痛治療法の開発, 平成17-19年度総合研究報告書 (主任研究者: 池田和隆), 31 - 52, Japanese


• 注意欠陥多動性障害(ADHD)とモノアミントランスポーター. 中枢神経系のトランスポーターをめぐって. (Clinical Neuroscience )

  曽良一郎, 福井麻美

  2008, Clinical Neuroscience, 10(26) (26), 1146 - 1147


• 【AD/HDの新しい薬物療法】 メチルフェニデートの依存リスク (精神科)

  曽良一郎

  2008, 精神科, 12(4) (4), 310 - 315


• トランスポーターの遺伝子改変動物と精神神経疾患. 中枢神経系のトランスポーターをめぐって. (Clinical Neuroscience )

  曽良一郎

  2008, Clinical Neuroscience, 10(26) (26), 1081 - 1083


• Candidate gene polymorphisms predicting individual sensitivity to opioids

  KASAI S

  Significant interindividual differences in opioid sensitivity can hamper effective pain treatment and increase the risk for substance abuse. Elucidation of the genetic mechanisms involved in the interindividual differences in opioid sensitivity would help establish personalized pain management. Studies using gene knockout mice have revealed that genes encoding some metabolic enzymes, opioid transporters, and opioid system signal transduction mediators may be candidate genes to predict appropriate kinds and doses of opioids for individuals. Recently, various databases on knockout mice, pharmacogenetics, and gene polymorphisms have been rapidly consolidated. Such information should aid in developing and improving the methods of predicting interindividual differences in opioid sensitivity. In the near future, it will be possible to predict the appropriate kinds and doses of opioids for individuals by analyzing genetic variations contributing to opioid sensitivity.

  2008, Naunyn Schmiedebergs Arch Pharmacol, 377(4月6日) (4月6日), 269 - 281, English, International magazine


• AD/HDの薬物療法 メチルフェニデートを巡って 薬物依存とメチルフェニデート

  曽良一郎, 猪狩もえ, 池田和隆

  日本精神神経学会, 2008, 精神神経学雑誌, 110(10) (10), 941 - 945, Japanese


• 注意欠陥多動性障害(ADHD)とモノアミントランスポーター. 中枢神経系のトランスポーターをめぐって. (Clinical Neuroscience )

  曽良一郎, 福井麻美

  2008, Clinical Neuroscience, 10(26) (26), 1146 - 1147


• トランスポーターの遺伝子改変動物と精神神経疾患. 中枢神経系のトランスポーターをめぐって. (Clinical Neuroscience )

  曽良一郎

  2008, Clinical Neuroscience, 10(26) (26), 1081 - 1083


• Candidate gene polymorphisms predicting individual sensitivity to opioids. (Naunyn Schmiedebergs Arch Pharmacol)

  Kasai Shinya, Hayashida Masakazu, Sora Ichiro, Ikeda Kazutaka

  2008, Naunyn Schmiedebergs Arch Pharmacol, 377(4月6日) (4月6日), 269 - 281


• 【AD/HDの新しい薬物療法】 メチルフェニデートの依存リスク (精神科)

  曽良一郎

  2008, 精神科, 12(4) (4), 310 - 315


• The Glycine Transporter 1 Gene (GLYT1) Is Associated With Methamphetamine-Use Disorder

  Yukitaka Morita, Hiroshi Ujike, Yuji Tanaka, Makiko Kishimoto, Yuko Okahisa, Tatsuya Kotaka, Mutsuo Harano, Toshiya Inada, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Shigetoshi Kuroda

  Jan. 2008, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 147B(1) (1), 54 - 58, English, International magazine


• PICK 1機能的遺伝子多型と覚せい剤精神病との関連

  松澤 大輔, 橋本 謙二, 宮武 良輔, 白山 幸彦, 清水 英司, 前田 和久, 鈴木 洋一, 真下 陽一, 関根 吉統, 稲田 俊也, 尾崎 紀夫, 岩田 仲生, 原野 睦生, 小宮山 徳太郎, 山田 光男, 曽良 一郎, 氏家 寛, 羽田 明, 澤 明, 伊豫 雅臣

  日本脳科学会, Jun. 2007, 日本脳科学会プログラム・抄録集, 34回, 39 - 39, Japanese


• 「依存性薬物および未規制薬物による神経毒性と精神病の発現機序」3年間のまとめ 依存性薬物の精神神経毒性と標的分子への作用機序の解明

  曽良一郎, 伊藤美紀, 小原可久, 朴英善, 阿部裕美, 山下元康, 福島攝, 近江香予, 小林秀昭, 岩村樹憲, 岩渕好治, 花尻瑠理, 合田幸広, 沼知陽太郎

  2007, 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 平成18年度 総括研究報告書 平成16-18年度 総合研究報告書


• 依存性薬物および未規制薬物による神経毒性と精神病の発現機序」3年間のまとめ 多剤乱用の実態と物質誘発性精神病の遺伝子リスクファクターの解明

  氏家寛, 森田幸孝, 大谷恭平, 岡久祐子, 岸本真希子, 小高辰也, 森尾亜希子, 稲田俊也, 原野陸正, 小宮山徳太郎, 堀達, 山田光彦, 関根吉統, 曽良一郎, 岩田仲生, 伊豫雅臣, 尾崎紀夫, 黒田重利

  2007, 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 平成18年度 総括研究報告書 平成16-18年度 総合研究報告書


• Chronic social defeat stressにおけるオピオイド神経伝達の役割

  小松浩, 小原可久, 服部寿妃, 阿部ひろみ, 畑春実, 曽良一郎

  2007, 日本生物学的精神医学会プログラム・講演抄録, 29th


• Analyses of antinociceptive effects of butorphanol in mu-opioid receptor knockout mice

  Soichiro Ide, Masabumi Minami, George R. Uhl, Kumatoshi Ishihara, Masamichi Satoh, Ichiro Sora, Kazutaka Ikeda

  2007, JOURNAL OF PHARMACOLOGICAL SCIENCES, 103, 184P - 184P, English

  Summary international conference


• 「依存性薬物および未規制薬物による神経毒性と精神病の発現機序」3年間のまとめ 薬物依存重症度評価法の構築と候補治療薬の探索

  池田和隆, 大谷保和, 原口彩子, 石橋曜子, 近藤あゆみ, 渡部崇, 妹尾栄一, 山本秀子, 萩野洋子, 高松幸雄, 笠井慎也, 岩村樹憲, 曽良一郎

  2007, 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 平成18年度 総括研究報告書 平成16−18年度 総合研究報告書, 137 - 165, Japanese


• 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 薬物依存重症度評価法の構築と候補治療薬の探索

  池田和隆, 大谷保和, 原口彩子, 渡部崇, 妹尾栄一, 山本秀子, 萩野洋子, 高松幸雄, 笠井慎也, 岩村樹憲, 曽良一郎

  2007, 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 平成18年度 総括研究報告書 平成16−18年度 総合研究報告書, 293 - 305, Japanese


• 癌性疼痛治療個人差の遺伝子メカニズムに関する研究

  曽良一郎, 小松浩, 村上敏文, 高橋秀徳, 阿部裕美, 井手総一郎, 下山直人, 池田和隆

  2007, 厚生労働科学研究費補助金(萌芽的先端医療技術推進研究事業), 遺伝子多型検査によるテーラーメイド疼痛治療法の開発, 平成18年度総括研究報告書 (主任研究者: 池田和隆), 19 - 31, Japanese


• 薬物依存の分子病態. (実験医学)

  曽良一郎

  2007, 実験医学, 25(13) (13), 179 - 184


• Monoamine transporter as a target molecule for psychostimulants.

  Sora Ichiro, Igari Moe, Yamamoto Hideko, Ikeda Kazutaka

  モノアミントランスポーターはコカイン，メチルフェニデート，メタンフェタミン（MAP）などの覚せい剤の標的分子であることから，覚せい剤依存の病態における役割を明らかにするための詳細な精神薬理学的研究が行われてきた．モノアミントランスポーターには，各モノアミンの前シナプス終末に主に発現する細胞膜モノアミントランスポーターと，すべてのモノアミンを基質とするシナプス小胞モノアミントランスポーター（VMAT）の2種類がある．覚せい剤は，モノアミン輸送を阻害し，神経細胞内外の分画モノアミン濃度を変化させ薬理効果を示す．コカインは細胞膜モノアミントランスポーター阻害作用を有し，その報酬効果はドパミントランスポーター（DAT）を介しているとする「DAT仮説」が提唱された．しかし，DATとセロトニントランスポーター（SERT）が共に関与していることが示された．ただし，SERTよりもDATがより大きな役割を果たしていると考えられる．「DAT仮説」は

  The Japanese Pharmacological Society, 2007, Nippon Yakurigaku Zasshi, 130(6) (6), 450 - 454, Japanese, Domestic magazine


• ADHD動物モデルとしてのドーパミントランスポーター欠損マウス. (脳と精神の医学)

  曽良一郎, 福島攝, 山本秀子, 池田和隆

  2007, 脳と精神の医学, 18(4) (4), 279 - 283


• ADHD動物モデルとしてのドーパミントランスポーター欠損マウス. (脳と精神の医学)

  曽良一郎, 福島攝, 山本秀子, 池田和隆

  2007, 脳と精神の医学, 18(4) (4), 279 - 283


• 薬物依存の分子病態. (実験医学)

  曽良一郎

  2007, 実験医学, 25(13) (13), 179 - 184


• Stimulant-induced sensitization in monoamine transporter mutant mouse

  FUKUSHIMA Setsu, SHEN Haowei, IKEDA Kazutaka, NUMACHI Yohtaro, KOBAYASHI Hideaki, SORA Ichiro, YAMASHITA Motoyasu, HAGINO Yoko

  Dec. 2006, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 25(6) (6), 340 - 340, Japanese


• MS6-2 精神的ストレスによるアレルギー性気道炎症増悪におけるμ-オピオイド受容体の役割(気道炎症2,ミニシンポジウム6,一般演題,第56回日本アレルギー学会秋季学術大会)

  奥山香織, 荒井良枝, 梶川聡子, 成瀬茉耶, 土橋和久, 田村弦, 櫻田忍, 曽良一郎, 高柳元明, 大野勲

  (一社)日本アレルギー学会, Sep. 2006, アレルギー, 55(8) (8), 1106 - 1106, Japanese


• Monoamine transporter as a target molecule for psychostimulants

  SORA ICHIRO, YAMAMOTO HIDEKO, IKEDA KAZUTAKA

  25 Aug. 2006, 神経化学, 45(2/3) (2/3), 244, Japanese


• PICK1遺伝子多型と覚せい剤乱用者の関連について

  松澤 大輔, 橋本 謙二, 宮武 良輔, 清水 栄司, 伊豫 雅臣, 関根 吉統, 稲田 俊也, 尾崎 紀夫, 岩田 仲生, 原野 睦夫, 小宮山 徳太郎, 山田 光彦, 曽良 一郎, 氏家 寛

  千葉医学会, Aug. 2006, 千葉医学雑誌, 82(4) (4), 242 - 242, Japanese


• セロトニン1B受容体と覚醒剤依存症の関連解析

  岸本真希子, 氏家寛, 氏家寛, 田中有史, 大谷恭平, 森尾亜希子, 岡久裕子, 小高辰也, 原野睦生, 稲田俊也, 山田光彦, 小宮山徳太郎, 堀達, 関根吉統, 岩田仲生, 曽根一郎, 伊豫雅臣, 尾崎紀夫, 黒田重利

  日本神経化学会, Aug. 2006, 神経化学, 45(2-3) (2-3), 397 - 397, Japanese


• NrCAM遺伝子多型と覚醒剤精神病の関連研究

  岡久 祐子, 氏家 寛, 田中 有史, 大谷 恭平, 森田 幸孝, 岸本 真希子, 森尾 亜希子, 小高 辰也, 稲田 俊也, 原野 睦生, 小宮山 徳太郎, 堀 達, 山田 光彦, 関根 吉統, 岩田 仲生, 伊豫 雅臣, 曽良 一郎, 尾崎 紀夫, 黒田 重利

  日本神経化学会, Aug. 2006, 神経化学, 45(2-3) (2-3), 398 - 398, Japanese


• Increased body weight in mice lacking mu-opioid receptors

  WH Han, H Hata, H Imbe, QR Liu, Y Takamatsu, M Koizumi, NP Murphy, E Senba, GR Uhl, Sora, I, K Ikeda

  Jun. 2006, NEUROREPORT, 17(9) (9), 941 - 944, English, International magazine


• Association Study and Postmortem Brain Analysis of Reelin Gene Polymorphisms with Schizophrenia in the Japanese Population

  ARAI MAKOTO, OBATA NANAKO, HAGA SEIICHI, YOSHIDA YUKI, IINA MIZUKI, ITO TAEKO, YAMADA KAZUO, TOYOTA TOMOKO, UJIKE HIROSHI, SORA ICHIRO, IKEDA KAZUHIKO, YOSHIKAWA TAKEO, ITOKAWA MASANARI

  25 Mar. 2006, 精神薬療研究年報, (38) (38), 115 - 121, Japanese


• 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 依存性薬物の精神神経毒性と標的分子への作用機序の解明

  曽良一郎, 小原可久, 伊藤美紀, 山下元康, 福島攝, 近江香予, 岩村樹憲, 岩渕好治, 小林秀昭, 沼知陽太郎

  2006, 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 平成17年度 総括研究報告書


• Prepulse Inhibition of the Acoustic Starle Response in Dopamine Transporter Knockout Mice Treated with Selective and Non-selective Norepinephrine Transporter Blockers

  山下元康, 福島摂, 有銘預世布, 沼知陽太郎, 小林秀昭, 曽良一郎

  2006, 精神薬療研究年報, (38) (38)


• 気分障害の高精度候補領域解析および精神疾患ゲノムバンクの構築 精神疾患ゲノムバンク対象疾患におけるChromogranin A遺伝子の大規模追加解析

  稲田俊也, 高橋長秀, 石原良子, 齋藤真一, 前野信久, 青山渚, 青山渚, 季暁飛, 前田貴記, 岩下覚, 岩田仲生, 伊豫雅臣, 原野睦生, 山田光彦, 関根吉統, 曽良一郎, 小宮山徳太郎, 氏家寛, 尾崎紀夫

  2006, 気分障害の高精度候補領域解析および精神疾患ゲノムバンクの構築 平成17年度 総括・分担研究報告書


• 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 多剤乱用の実態と物質誘発性精神病の遺伝子リスクファクターの解明 FZD-3,XBP-1およびFAAH遺伝子の検討

  氏家寛, 岸本真希子, 森田幸孝, 大谷恭平, 岡久祐子, 森尾亜希子, 稲田俊也, 原野陸正, 小宮山徳太郎, 堀達, 山田光彦, 関根吉統, 曽良一郎, 岩田仲生, 伊豫雅臣, 尾崎紀夫, 黒田重利

  2006, 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 平成17年度 総括研究報告書


• New therapies and prophylaxis for psychiatric disorders based on molecular pathology. Prepulse inhibition of the acoustic startle reflex in schizophrenic patients.

  曽良一郎, 山下元康, 福島攝, 小原可久, 小林秀昭, 伊藤文晃, 島袋仁, 中村真樹, 坂本修一, 鈴木陽一, 松岡洋夫, 沼知陽太郎

  2006, 精神疾患の分子病態解明による新しい治療・予防法の開発に関する研究 平成15-17年度 総括・分担研究報告書, 22 - 26, Japanese


• Distinct effects of MDMA and 5-MeO-DIPT on extracellular dopamine and serotonin levels

  Hagino Y, Takamatsu Y, Yamamoto H, Iwamura T, Sora I, Ikeda K

  2006, 日本神経精神薬理学雑誌, 26, 259


• 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 薬物依存重症度評価法の構築と候補治療薬の探索

  池田和隆, 大谷保和, 原口彩子, 石橋曜子, 妹尾栄一, 萩野洋子, 山本秀子, 高松幸雄, 笠井慎也, 岩村樹憲, 曽良一郎

  2006, 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 平成17年度 総括研究報告書, 123 - 135, Japanese


• 遺伝子多型検査によるテーラーメイド疼痛治療法の開発 癌性疼痛治療個人差の遺伝子メカニズムに関する研究

  曽良一郎, 小松浩, 山下元康, 村上敏史, 畑春実, 井手聡一郎, 城戸幹太, 高橋雅彦, 糸川昌成, 沼知陽太郎, 小林秀昭, 下山直人, 池田和隆

  2006, 遺伝子多型検査によるテーラーメイド疼痛治療法の開発 平成17年度 総括研究報告書, 19 - 35, Japanese


• 神経障害性疼痛の疾患脆弱性に関する遺伝子解析

  曽良一郎, 小松浩, 井手聡一郎, 阿部裕美, 城戸幹太, 高橋雅彦, 糸川昌成, 池田和隆

  2006, 平成18年度厚生労働省がん研究助成事業「がん患者に対する支持療法及び緩和療法の技術の向上に関する研究」第1回班会議, Japanese


• MS5-6 精神的ストレス誘発性喘息におけるμ-オピオイド受容体の関与(動物モデルによる解析,ミニシンポジウム,一般演題,第18回日本アレルギー学会春季臨床大会)

  奥山香織, 荒井良枝, 梶川聡子, 成瀬茉耶, 田村弦, 櫻田忍, 曽良一郎, 高柳元明, 大野勲

  一般社団法人 日本アレルギー学会, 2006, アレルギー, 55(3) (3), 403 - 403, Japanese


• [An update on animal model studies of attention-deficit/hyperactivity disorder]

  Sora Ichiro, Fukushima Setsu

  注意欠陥・多動性障害（AD/HD：Attention Deficit/Hyperactivity Disorder）における治療薬として使用されているアンフェタミンなどの覚せい剤の作用メカニズムについては十分に解明されていないが，覚せい剤がドパミン（DA）やノルエピネフリン（NE）などの中枢性カテコールアミンを増やすことから，ADHDへの治療効果が中枢神経系におけるカテコールアミン神経伝達を介していることは明らかである．モノアミントランスポーターは主に神経終末の細胞膜上に位置し，細胞外に放出されたモノアミンを再取り込みすることによって細胞外濃度を調節している．ドパミントランスポーター（DAT）は覚せい剤の標的分子であり，ADHDとの関連が注目されている．野生型マウスに覚せい剤であるメチルフェニデートを投与すると運動量が増加するが，多動性を有しADHDの動物モデルと考えられているDAT欠損マウスでは，メチルフェニデート投与により運動量が低下する．野生型マウスではメチルフェニデー

  The Japanese Pharmacological Society, 2006, FOLIA PHARMACOLOGICA JAPONICA, 128(1) (1), 8 - 12, Japanese, Domestic magazine


• 第3回 Schizophrenia研究会 講演紹介 ( 臨床精神薬理)

  曽良一郎

  2006, 臨床精神薬理, 1664 - 1702


• 第3回 Schizophrenia研究会 講演紹介. (臨床精神薬理)

  岡崎祐士, 曽良一郎, 前田久雄, 融道男, 臺弘, 氏家寛, 福田正人, 松岡洋夫, 米田博, 小澤寛樹, 倉知正

  2006, 臨床精神薬理, 9(8) (8), 1703 - 1713


• 前頭葉のモノアミン神経伝達による行動制御機構 (実験医学)

  曽良一郎, 有銘預世布

  2006, 実験医学, 84 - 89


• 集中内観を受けて (精神医学)

  曽良一郎

  2006, 精神医学, 704 - 705


• 違法ドラッグと覚せい剤の精神神経毒性と標的分子への作用機序 (医学のあゆみ)

  曽良一郎, 伊藤美紀, 沼知陽太郎

  2006, 医学のあゆみ, 1152 - 1154


• モノアミン神経伝達と「こころの病」 (Bionics)

  曽良一郎, 朴

  オーム社, 2006, Bionics, 3(11) (11), 40 - 45, Japanese


• モノアミン神経伝達と「こころの病」 (Bionics)

  曽良一郎, 朴

  オーム社, 2006, Bionics, 3(11) (11), 40 - 45, Japanese


• 第3回 Schizophrenia研究会 講演紹介 ( 臨床精神薬理)

  曽良一郎

  2006, 臨床精神薬理, 1664 - 1702


• 前頭葉のモノアミン神経伝達による行動制御機構 (実験医学)

  曽良一郎, 有銘預世布

  2006, 実験医学, 84 - 89


• 集中内観を受けて (精神医学)

  曽良一郎

  2006, 精神医学, 704 - 705


• 違法ドラッグと覚せい剤の精神神経毒性と標的分子への作用機序 (医学のあゆみ)

  曽良一郎, 伊藤美紀, 沼知陽太郎

  2006, 医学のあゆみ, 1152 - 1154


• 第3回 Schizophrenia研究会 講演紹介. (臨床精神薬理)

  岡崎祐士, 曽良一郎, 前田久雄, 融道男, 臺弘, 氏家寛, 福田正人, 松岡洋夫, 米田博, 小澤寛樹, 倉知正

  2006, 臨床精神薬理, 9(8) (8), 1703 - 1713


• Repeated methamphetamine administration alters the expression of kinesins in mouse brain

  YAMAMOTO Hideko, KAMEGAYA Etsuko, TAKAMATSU Yukio, HAGINO Yoko, YAMAMOTO Toshifumi, IMAI Kazuhide, SHIMADA Kiyo, IWATA Ken, NUMACHI Yotaro, SORA Ichiro, KOGA Hisashi, IKEDA Kazutaka

  Dec. 2005, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 25(6) (6), 341 - 341, Japanese


• Involvement of 3' untranslated region of mouse mu-opioid receptor gene in morphine analgesia

  KASAI Shinya, HAN Wenhua, HATA Harumi, TAKAHASHI Takehiro, TAKAMATSU Yukio, YAMAMOTO Hideko, R. Uhl George, SORA Ichiro, IKEDA Kazutaka

  Dec. 2005, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 25(6) (6), 346 - 346, Japanese


• Impairment of cognition and attention in hyperdopaminergic mice

  YAMASHITA Motoyasu, NUMACHI Yohtaro, FUKUSHIMA Setsu, YOSHIDA Sumiko, KOBAYASHI Hideaki, SORA Ichiro

  Dec. 2005, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 25(6) (6), 310 - 310, Japanese


• Neurotoxicity of serotonergic drug of abuse : MDMA and 5-MeO-DIPT

  NUMACHI Yohtaro, YAMASHITA Motoyasu, FUKUSHIMA Setsu, OHARA Arihisa, OHMI Kayo, YAMAMOTO Hideko, IWAMURA Tatsunori, IWABUCHI Yoshiharu, KOBAYASHI Hideaki, SORA Ichiro

  Dec. 2005, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 25(6) (6), 343 - 343, Japanese


• Localization of 5-HT in DA neuron of 5-HT transporter knockout mouse

  KOBAYASHI Hideaki, NAKA Maki, OHMI Kayo, NUMACHI Yohtaro, SORA Ichiro

  Dec. 2005, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 25(6) (6), 311 - 311, Japanese


• Analyses of plausible model animals for ADHD

  IKEDA Kazutaka, TAKAMATSU Yukio, HAGINO Yoko, NAKAMOTO Yurie, YOSHII Mitsunobu, FUKUSHIMA Setsu, SORA Ichiro

  25 Sep. 2005, 脳と精神の医学 = Brain science and mental disorders, 16(3) (3), 161 - 167, Japanese


• 主観的聴覚刺激評価尺度を用いた新たなヒトPrepulse Inhibition測定法の開発

  山下元康, 小原可久, 坂本修一, 中村真樹, 福島摂, 小林秀昭, 沼知陽太郎, 鈴木陽一, 松岡洋夫, 曽良一郎

  25 Aug. 2005, 精神神経学雑誌, 107(8) (8), 905, Japanese


• メタアンフェタミンによってもたらされるμオピオイド受容体の変化 生化学的マーカーの候補(Methamphetamine-induced changes of μ-opioid receptors: a candidate of biochemical marker)

  山本 秀子, 亀ヶ谷 悦子, 今井 一英, 高松 幸雄, 笠井 慎也, 山本 敏文, 萩野 洋子, 五十子 将史, 佐藤 彬, 曽良 一郎, 古閑 比佐志, 池田 和隆

  日本神経化学会, Aug. 2005, 神経化学, 44(2-3) (2-3), 210 - 210, English


• 話題になった遺伝子多型のその後(第11回)μオピオイド受容体(OPRM1)遺伝子多型

  小林 秀昭, 曽良 一郎

  先端医学社, Jul. 2005, 分子精神医学, 5(3) (3), 312 - 322, Japanese


• 覚醒剤精神病とGlutathione S-transferase P1機能的遺伝子多型との関連について

  橋本 佐, 橋本 謙二, 松澤 大輔, 清水 栄司, 関根 吉統, 稲田 俊也, 尾崎 紀夫, 岩田 仲生, 原野 睦夫, 小宮山 徳太郎, 山田 光彦, 曽良 一郎, 氏家 寛, 伊豫 雅臣

  覚醒剤乱用の病態形成におけるGSTP1の潜在的な役割を明らかにするため,覚醒剤関連性障害と診断された対象者におけるGSTP1遺伝子多型について解析した.覚醒剤乱用者で精神病を伴う患者と健常者との間でgenotype頻度およびallele頻度において有意な差がみられた.GSTP1 exon 5遺伝子の多型が,覚醒剤乱用での精神病発症の脆弱性に関与している可能性が示唆された

  (公財)先進医薬研究振興財団, Mar. 2005, 精神薬療研究年報, (37) (37), 100 - 107, Japanese


• μオピオイド受容体遺伝子多型と寛醒剤精神病,統合失調症ならびにアルコール依存症との相関解析

  井手 聡一郎, 小林 秀昭, 長谷川 準子, 氏家 寛, 関根 吉統, 尾崎 紀夫, 稲田 俊也, 原野 睦生, 岩田 仲生, 小宮山 徳太郎, 山田 光彦, 伊豫 雅臣, 岩橋 和彦, 糸川 昌成, 有波 忠雄, 石黒 浩毅, 池田 和隆, 曽良 一郎

  (公社)日本薬理学会, Feb. 2005, 日本薬理学雑誌, 125(2) (2), 26P - 26P, Japanese


• メタンフェタミン依存とδオピオイド受容体(OPRD)遺伝子多型に関する相関研究

  小林秀昭, 仲真樹, 畑春実, 氏家寛, 尾崎紀夫, 関根吉統, 稲田俊也, 原野睦生, 岩田仲生, 小宮山徳太郎, 山田光彦, 伊予雅臣, 沼知陽太郎, 糸川昌成, 曽良一郎, 曽良一郎

  2005, 日本生物学的精神医学会プログラム・講演抄録, 27th


• ADHD動物モデルとしてのドーパミントランスポーター欠損マウスにおけるSSRIの効果

  福島摂, 沈こう偉, 山下元康, 萩野洋子, 池田和隆, 沼知陽太郎, 小林秀昭, 曽良一郎

  2005, 日本生物学的精神医学会プログラム・講演抄録, 27th


• ノルエピネフリン取り込み阻害剤によるプレパルス・インヒビション改善効果

  山下元康, 福島摂, 小林秀昭, 近江香予, 沼知陽太郎, 曽良一郎

  2005, 日本生物学的精神医学会プログラム・講演抄録, 27th


• ポストゲノム時代のブラックボックス 行動を司る脳機能の分子メカニズム モノアミン神経系と報酬,薬物依存

  曽良一郎, 小林秀昭

  2005, 実験医学, 23(8) (8)


• Prepulse inhibition of the acoustic startle response in monoamine transporter knockout mice treated with selective dopamine D2 antagonist

  曽良一郎, 山下元康, 近江香予, 福島摂, 小原可久, 那波宏之, 沼知陽太郎, 小林秀昭

  2005, 精神薬療研究年報, (37) (37)


• 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 未規制を含む依存性薬物の精神神経毒性と標的分子への作用機序の解明

  曽良一郎, 沼知陽太郎, 小原可久, 山下元康, 福島攝, 近江香予, 岩村樹憲, 岩渕好治, 小林秀昭

  2005, 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 平成16年度 総括研究報告書


• CART遺伝子と覚せい剤依存症との関連研究

  森尾亜希子, 氏家寛, 氏家寛, 野村晃, 田中有史, 森田幸孝, 大谷恭平, 岸本真希子, 稲田俊也, 稲田俊也, 原野睦生, 原野睦生, 小宮山徳太郎, 小宮山徳太郎, 山田光彦, 山田光彦, 関根吉統, 関根吉統, 岩田仲生, 岩田仲生, 伊予雅臣, 伊予雅臣, 曽良一郎, 曽良一郎, 尾崎紀夫, 尾崎紀夫, 黒田重利

  2005, 日本生物学的精神医学会プログラム・講演抄録, 27th


• The human fatty acid amide hydrolaseの機能的遺伝子多型と覚せい剤依存症および統合失調症との関連研究

  森田幸孝, 氏家寛, 氏家寛, 田中有史, 田中有史, 野村晃, 大谷恭平, 内田有彦, 岸本真希子, 森尾亜希子, 稲田俊也, 稲田俊也, 原野睦正, 原野睦正, 小宮山徳太郎, 小宮山徳太郎, 山田光彦, 山田光彦, 関根吉統, 関根吉統, 岩田仲生, 岩田仲生, 伊予雅臣, 伊予雅臣, 曽良一郎, 曽良一郎, 尾崎紀夫, 尾崎紀夫, 黒田重利

  2005, 日本生物学的精神医学会プログラム・講演抄録, 27th


• Studies of development, effectiveness evaluation, and standardization of drug dependence, alcoholism, and toxic psychosis treatment. Studies of genetic risk factor of stimulant drug dependence. Gene correlation research in tumor necrotizing factor alpha gene and prodynorphin gene.

  氏家寛, 野村晃, 岸本真希子, 大谷恭平, 森田幸孝, 田中有史, 稲田俊也, 原野睦夫, 小宮山徳太郎, 山田光彦, 関根吉統, 曽良一郎, 岩田仲生, 伊予雅臣, 尾崎紀夫, 黒田重利

  2005, 厚生労働省精神・神経疾患研究委託費による研究報告集 平成16年度 (2年度班・初年度班)


• FZD3遺伝子と覚醒剤精神病の関連研究

  岸本真希子, 氏家寛, 氏家寛, 田中有史, 野村晃, 大谷恭平, 森田幸孝, 森尾亜希子, 原野睦生, 原野睦生, 稲田俊也, 稲田俊也, 山田光彦, 山田光彦, 小宮山徳太郎, 小宮山徳太郎, 関根吉統, 関根吉統, 岩田仲生, 岩田仲生, 曽良一郎, 曽良一郎, 伊予雅臣, 伊予雅臣, 尾崎紀夫, 尾崎紀夫, 黒田重利

  2005, 日本生物学的精神医学会プログラム・講演抄録, 27th


• 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 多剤乱用の実態と物質誘発性精神病の遺伝子リスクファクターの解明 FDZ-3およびCYP2D6遺伝子の検討

  氏家寛, 大谷恭平, 岸本真希子, 坂井歩, 野村晃, 森尾亜希子, 森田幸孝, 稲田俊也, 原野陸正, 小宮山徳太郎, 山田光彦, 関根吉統, 曽良一郎, 岩田仲生, 伊豫雅臣, 尾崎紀夫, 黒田重利

  2005, 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 平成16年度 総括研究報告書


• 統合失調症における主観的刺激音強度評価尺度を用いたプレパルス・インヒビション(PPI‐PSI)

  山下元康, 伊藤文晃, 島袋仁, 中村真樹, 小原可久, 沼知陽太郎, 松岡洋夫, 曽良一郎

  2005, 日本精神神経学会総会プログラム・抄録集, 101st, S.218, Japanese


• メタンフェタミン神経毒性、体温変化におけるモノアミン神経伝達の関与

  沼知陽太郎, 小原可久, 小林秀昭, 山下元康, 福島攝, 近江香予, 畑春実, 矢野板信裕, 渡邉秀和, 沈昊偉, 山本秀子, 池田和隆, 曽良一郎

  2005, 日本神経精神薬理学雑誌, 24, 406


• 統合失調症におけるリーリン遺伝子の解析

  新井誠, 中島みずほ, 小幡菜々子, 山田和男, 羽賀誠一, 豊田倫子, 氏家寛, 曽良一郎, 池田和彦, 吉川武男, 糸川昌成

  2005, 日本生物学的精神医学会プログラム・講演抄録, 27th, 181, Japanese


• 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 薬物依存重症度評価法の構築と候補治療薬の探索

  池田和隆, 大谷保和, 原口彩子, 近藤あゆみ, 高松幸雄, 山本秀子, 萩野洋子, 笠井慎也, 曽良一郎, 妹尾栄一

  2005, 依存性薬物および未規制薬物による神経毒性と精神病の発現機序 平成16年度 総括研究報告書, 101 - 110, Japanese


• Therapy development for psychiatric disorders by solving the molecular pathology. Sensorimotor information processing gene altered mouse model and human PPI-PSI.

  SORA ICHIRO, YAMASHITA MOTOYASU, KOBAYASHI HIDEAKI, FUKUSHIMA SETSU, SAKAMOTO SHUICHI, NAKAMURA MAKI, MATSUOKA HIROO, SUZUKI YOICHI, KOMATSU HIROSHI, YAMAMOTO HIDEKO, IKEDA KAZUTAKA, NAHA HIROYUKI, NUMACHI YOTARO

  2005, 厚生労働省精神・神経疾患研究委託費による研究報告集 平成16年度 (2年度班・初年度班), 134, Japanese


• [Distinct mechanisms underlying pleasure and analgesia]

  Ide Soichiro, Minami Masabumi, Satoh Masamichi, Sora Ichiro, Ikeda Kazutaka

  近年，疼痛緩和ケアが重視される中で，情動が病態や治療に与える影響が注目されている．オピオイド神経系は，情動の中でも快と痛みに深く関係しており，その作動薬であるモルヒネなど麻薬性鎮痛薬は有用な鎮痛効果をもたらす．また，痛みを感じている状況下では依存が形成されないことなどから，オピオイドの快と鎮痛作用が分離出来る可能性が示唆されている．近年，ノックアウトマウスを用いた実験などでは，麻薬性鎮痛薬の主たる作用部位であるµオピオイド受容体が，モルヒネを始めとした多くの麻薬性鎮痛薬の鎮痛効果，報酬効果において中心的な役割を果たすことが示されてきた．しかし，オピオイド鎮痛薬の一つであるブプレノルフィンでは，µオピオイド受容体が欠損すると，鎮痛効果は完全に消失するが，報酬効果は残存することが明らかになった．オピオイドによる快と鎮痛発生機構はやはり一部異なると考えられる．また，アルコールや覚醒剤の報酬効果と

  The Japanese Pharmacological Society, 2005, Nippon Yakurigaku Zasshi, 125(1) (1), 11 - 15, Japanese, Domestic magazine


• 第2回 Schizophrenia研究会 講演紹介 ( 臨床精神薬理)

  岡崎祐士, 豊嶋良一, 倉知正佳, 松岡洋夫, 林拓二, 福田正人, 西川徹, 丹波真一, 氏家寛, 曽良一郎

  2005, 臨床精神薬理, 152 - 168


• [Genetically modified animals as models for psychiatric diseases]

  Sora Ichiro, Kobayashi Hideaki, Numachi Yotaro

  Animal models of mental disorders as well as physical disorders have been useful tools to elucidate pathophysiology of the complex disorders and develop new therapeutics. Transgenic mice including gene knockout animals have been produced by gene targeting technology. Monoamine system which is target of antipsychotics and antidepressants has very important roles in pathology of functional psychosis. In this review, we would like to introduce monoamine transporter knockout mice that we had generated as animal models of mental disorders including schizophrenia and drug abuse.

  日本精神神経学会, 2005, Psychiatria et neurologia Japonica, 107(3) (3), 285 - 289, Japanese, Domestic magazine


• What to do before behavioral analysis of knockout mice. (日本薬理学雑誌)

  Sora Ichiro, Fukushima Setsu

  近年ノックアウトマウス作製技術の向上に伴い，多くの研究室でノックアウトマウスを保有し，様々な表現型解析，行動解析が行われている．ノックアウトマウスの入手法には作製，提供，購入の3通りの手段がある．いずれかの方法でノックアウトマウスを所有した場合，実験計画に合わせてマウスを繁殖させ，飼育していかなければならない．繁殖，飼育にはいくつか注意点があり，例えば成長障害のあるマウスでは死亡数をいかに減らすかが効率よく実験を進める上で重要となる．成長したノックアウトマウスを実験に使う場合，マウスの遺伝型判別が前提となり，正確な個体識別が必須となる．また実際に実験を進めていく上で，マウスの遺伝背景や環境因子にも注意しなければならない．本稿では，ノックアウトマウスを用いた研究を行っていくための，マウスの繁殖・飼育方法や個体識別法，行動解析を行う上での注意事項などを，筆者らの経験をもとに紹介する．

  公益社団法人 日本薬理学会, 2005, 日本薬理学雑誌, 125(6) (6), 373 - 377, Japanese, Domestic magazine


• μオピオイド受容体(OPRM1)遺伝子多型 (分子精神医学)

  小林秀昭, 曽良一郎

  2005, 分子精神医学, 64 - 74


• モルヒネ感受性の遺伝子解析．遺伝子診療学？遺伝子診断の進歩と遺伝子治療の展望 (日本臨床)

  池田和隆, 大谷保和, 西澤大輔, 井手総一郎, 曽良一郎

  2005, 日本臨床, 463 - 466


• モノアミン神経系と報酬. 特集：行動を司る脳機能の分子メカニズム (実験医学)

  曽良一郎, 小林秀昭

  2005, 実験医学, 1159 - 1163


• ADHDのモデル動物の解析 Analyses of ADHD model animal (脳と精神の医学)

  池田和隆, 高松幸雄, 萩野洋子中本百合江, 吉井光信, 福島攝, 曽良一郎

  2005, 脳と精神の医学, 161 - 167


• ADHDのモデル動物の解析 Analyses of ADHD model animal (脳と精神の医学)

  池田和隆, 高松幸雄, 萩野洋子中本百合江, 吉井光信, 福島攝, 曽良一郎

  2005, 脳と精神の医学, 161 - 167


• モルヒネ感受性の遺伝子解析．遺伝子診療学？遺伝子診断の進歩と遺伝子治療の展望 (日本臨床)

  池田和隆, 大谷保和, 西澤大輔, 井手総一郎, 曽良一郎

  2005, 日本臨床, 463 - 466


• 第2回 Schizophrenia研究会 講演紹介 ( 臨床精神薬理)

  岡崎祐士, 豊嶋良一, 倉知正佳, 松岡洋夫, 林拓二, 福田正人, 西川徹, 丹波真一, 氏家寛, 曽良一郎

  2005, 臨床精神薬理, 152 - 168


• μオピオイド受容体(OPRM1)遺伝子多型 (分子精神医学)

  小林秀昭, 曽良一郎

  2005, 分子精神医学, 64 - 74


• モノアミン神経系と報酬. 特集：行動を司る脳機能の分子メカニズム (実験医学)

  曽良一郎, 小林秀昭

  2005, 実験医学, 1159 - 1163


• [Genetically modified animals as models for psychiatric diseases] (精神神経学雑誌)

  Sora Ichiro, Kobayashi Hideaki, Numachi Yotaro

  2005, 精神神経学雑誌, 107(3) (3), 285 - 289


• [Distinct mechanisms underlying pleasure and analgesia] (Nippon Yakurigaku Zasshi)

  Ide Soichiro, Minami Masabumi, Satoh Masamichi, Sora Ichiro, Ikeda Kazutaka

  2005, Nippon Yakurigaku Zasshi, 125(1) (1), 11 - 15


• ドーパミントランスポーター欠損マウス活動量に与えるmethylphenidateの2面的効果

  高松幸雄, 高橋雄大, 萩野洋子, 山本秀子, 猪子香代, 俵和也, UHL G R, 曽良一郎, 池田和隆

  25 Dec. 2004, 日本神経精神薬理学雑誌, 24(6) (6), 352, Japanese


• シナプス小胞モノアミントランスポーター(VMAT‐2)完全欠損によるドーパミントランスポーターの抑制的調節

  山本秀子, 亀ケ谷悦子, 萩野洋子, 池田和隆, 山本敏文, 小林秀昭, 沼知陽太郎, 竹島多賀夫, 曽良一郎

  25 Dec. 2004, 日本神経精神薬理学雑誌, 24(6) (6), 351, Japanese


• コカインの分子作用機序におけるモノアミントランスポーターの役割

  沈昊偉, 小林秀昭, 萩野洋子, 小原可久, 山下元康, 福島攝, 山本敏文, 山本秀子, 沼知陽太郎, 池田和隆, 曽良一郎

  Dec. 2004, 日本神経精神薬理学雑誌, 24(6) (6), 401, Japanese


• μオピオイド受容体KOマウスにおけるモルヒネ類の鎮痛効果と副作用

  曽良一郎, 渡辺秀和, 畑春実, 井手聡一郎, 池田和隆, 高橋雅彦, 山室誠

  25 Jun. 2004, 日本ペインクリニック学会誌, 11(3) (3), 307, Japanese


• Functional identification of ASCT1 neutral amino acid transporter as the predominant system for the uptake of L-serine in rat neurons in primary culture

  Toshifumi Yamamoto, Itone Nishizaki, Toshihide Nukada, Etsuko Kamegaya, Shigeki Furuya, Yoshio Hirabayashi, Kazutaka Ikeda, Harumi Hata, Hideaki Kobayashi, Ichiro Sora, Hideko Yamamoto

  May 2004, Neuroscience Research, 49(1) (1), 101 - 111, English, International magazine


• Association between the glutathione S-transferase M1 gene deletion and female methamphetamine abusers

  H Koizumi, K Hashimoto, C Kumakiri, E Shimizu, Y Sekine, N Ozaki, T Inada, M Harano, T Komiyama, M Yamada, Sora, I, H Ujike, N Takei, M Iyo

  Apr. 2004, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 126B(1) (1), 43 - 45, English, International magazine


• Genetic analysis of NCAM1, STX and PST genes on schizophrenia

  ARAI MAKOTO, ITOKAWA MASANARI, YAMADA KAZUO, TOYOTA TOMOKO, HAGA SEIICHI, UJIKE HIROSHI, SORA ICHIRO, IKEDA KAZUHIKO, YOSHIKAWA TAKEO

  25 Mar. 2004, 精神薬療研究年報, (36) (36), 100 - 113, Japanese


• 5-HT3受容体遺伝子上多型による統合失調症・覚醒剤使用障害・人格傾向との関連解析

  尾崎 紀夫, 北島 剛司, 岩田 仲生, 前野 信久, 鈴木 竜世, 池田 匡志, 西山 毅, 稲田 俊也, 氏家 寛, 原野 睦生, 小宮山 徳太郎, 山田 光彦, 関根 吉統, 伊豫 雅臣, 曽良 一郎

  セロトニン(5-HT)3A受容体遺伝子は精神疾患の遺伝子研究に置いて重要な候補遺伝子であると考えられるが,日本人DNAを用いた5-HT3A受容体遺伝子上の多型検索もそれを用いた関連解析も報告されていない.そこで,日本人の精神疾患患者サンプルを用いて多型検索を行い,数種類の一塩基多型(SNP)を同定し,更に統合失調症,覚醒剤使用障害ならびに人格傾向との関連解析を行った.9個の一塩基多型を同定し,exon 1の5'UTRの2多型,exon 2のアミノ酸置換を伴う1多型,5'側intronのbranch site近傍の1多型,exon 9のアミノ酸置換を伴う1多型が機能的意義を持つ可能性が示唆された.統合失調症および覚醒剤使用障害ならびに人格傾向との関連は見られなかった

  厚生労働省精神・神経疾患研究班, Mar. 2004, 厚生労働省精神・神経疾患研究総括研究報告 新しい診断・治療法の開発に向けた精神疾患の分子メカニズム解明に関する研究, (平成12〜14年) (平成12〜14年), 41 - 46, Japanese


• Prepulse inhibition in Monoamine Transporter Knockout Mice

  SORA ICHIRO, KOBAYASHI HIDEAKI, YAMASHITA MOTOYASU, OUMI KAYO, TOUMI MANABU, SHEN H W, YAMAMOTO HIDEKO, IKEDA KAZUTAKA, NAWA HIROYUKI

  Mar. 2004, 精神薬療研究年報, (36) (36), 120 - 126, Japanese


• 覚せい剤の神経毒性、体温変化に対するドーパミン・セロトニン神経系の関与

  佐藤光源, 沼知陽太郎, 小原可久, 山下元康, 近江香予, 福島攝, 畑春実, 小林秀昭, 沈昊偉, 山本秀子, 池田和隆, 曽良一郎

  2004, 平成15年度厚生労働科学研究費補助金(医薬安全総合研究事業)研究「規制薬物の依存及び神経毒性の発現にかかわる仕組みの分子生物学的解明に関する研究 (研究代表者 曽良一郎)」平成13-15年度総括研究報告書, 208 - 211, Japanese


• 覚醒剤の分子作用機序におけるモノアミントランスポーターの役割

  曽良一郎, 沈昊偉, 萩野洋子, 小林秀昭, 山下元康, 福島攝, 小原可久, 山本敏文, 山本秀子, 池田和隆, 沼知陽太郎

  2004, 平成15年度厚生労働科学研究費補助金(医薬安全総合研究事業)研究「規制薬物の依存及び神経毒性の発現にかかわる仕組みの分子生物学的解明に関する研究 (研究代表者 曽良一郎)」平成13-15年度総括研究報告書, 152 - 159, Japanese


• モノアミントランスポーター欠損マウスモデルを用いた覚醒剤の分子作用機序の検討: 3年間のまとめ

  曽良一郎, 沈昊偉, 萩野洋子, 小林秀昭, 井手聡一郎, 近江香予, 山下元康, 福島攝, 小原可久, 山本敏文, 山本秀子, 池田和隆, 沼知陽太郎

  2004, 平成15年度厚生労働科学研究費補助金 (医薬安全総合研究事業) 研究「規制薬物の依存及び神経毒性の発現にかかわる仕組みの分子生物学的解明に関する研究 (研究代表者 曽良一郎)」平成13-15年度総括研究報告書, 44 - 59, Japanese


• [Genetic studies on substance dependence] (Seishin Shinkeigaku Zasshi)

  Ujike Hiroshi, Inada Toshiya, Harano Mutsuo, Komiyayama Tokutaro, Yamada Mitsuhiko, Sekine Yoshinori, Sora Ichiro, Iwata Nakao, Iyo Masaomi, Ozaki Norio

  2004, Seishin Shinkeigaku Zasshi, 106(12) (12), 1598 - 1603, Japanese, Domestic magazine


• 双極性障害および統合失調症における性差と神経細胞接着分子の関連研究

  新井誠, 山田和男, 豊田倫子, 羽賀誠一, 氏家寛, 曽良一郎, 池田和彦, 吉川武男, 糸川昌成

  2004, 脳と神経の医学, 477 - 488


• 覚醒剤の体内動態と脳内分布 (Clinical Neuroscience)

  沼知陽太郎, 吉田寿美子, 曽良一郎, 佐藤光源

  2004, Clinical Neuroscience, 693 - 695


• Pathophysiology of drug addiction and schizophrenia : research using transgenic animal models at Department of Psychobiology, Tohoku University Graduate School of Medicine

  SORA Ichiro, FUKUSHIMA Setsu, YAMASHITA Motoyasu, KOBAYASHI Hideaki, NUMACHI Yohtaro

  2004, 脳と精神の医学, 15(3) (3), 311 - 316, Japanese


• モノアミン神経伝達と報酬の分子メカニズム

  曽良一郎, 沈昊偉, 小林秀昭

  2004, 応用薬理, 66(3) (3), 241 - 245, Japanese


• オピオイド受容体の分子生物学 (日本ペインクリニック学会誌 )

  曽良一郎, 渡邉秀和, 畑春実

  2004, 日本ペインクリニック学会誌, 11(4) (4), 406 - 410


• [Survey on the abuse of uncontrolled drugs by using the Internet]

  Ohara Yoshihisa, Numachi Yotaro, Kobayashi Hideaki, Yamashita Motoyasu, Watanabe Hidekazu, Fukushima Setsu, Komatsu Hiroshi, Hata Harumi, Naka Maki, Omi Koko, Sora Ichiro

  未規制薬物乱用の全体像を把握するため,インターネットによる情報流通の密度等から,乱用の実態の推測を試みた.その結果,法的な規制/未規制というのは,薬物毒性の低度を直接的に反映しておらず,未規制でも使用者人口がそれなりに存在しながら,具体的な研究がなされておらず,薬物毒性に対する被害が推測されながら実際には確認されていない物質が多々見受けられた.このような未規制薬物の薬理学的解析モデルを動物等を利用して,精神・神経毒性を明らかにする研究の推進が急務である.さらに研究推進により得られた未規制薬物の精神・神経毒性に関する正確な知識の啓蒙も必要と考えられた

  (一社)日本神経精神薬理学会, 2004, Japanese journal of psychopharmacology, 24(5) (5), 316 - 318, Japanese, Domestic magazine


• [Study on genes involved in pathogenesis of schizophrenia with DNA microarray]

  Itokawa Masanari, Arai Makoto, Ujiie Hiroshi, Sora Ichiro, Yoshikawa Takeo, Ikeda Kazuhiko

  日本精神神経学会, 2004, Seishin Shinkeigaku Zasshi, 106(1) (1), 42 - 48, Japanese, Domestic magazine


• 双極性障害および統合失調症における性差と神経細胞接着分子の関連研究

  新井誠, 山田和男, 豊田倫子, 羽賀誠一, 氏家寛, 曽良一郎, 池田和彦, 吉川武男, 糸川昌成

  2004, 脳と神経の医学, 477 - 488


• モノアミン神経伝達と報酬の分子メカニズム (応用薬理 )

  曽良一郎, 沈昊偉, 小林秀昭

  2004, 応用薬理, 241 - 245


• 遺伝子改変マウスモデルを用いた薬物依存と統合失調症の病態研究 東北大学精神・神経生物学分野における取り組みを中心に (脳と精神の医学)

  曽良一郎, 福島攝, 山下元康, 小林秀昭, 沼知陽太郎

  2004, 脳と精神の医学, 15(3) (3), 311 - 316, Japanese


• 覚醒剤の体内動態と脳内分布 (Clinical Neuroscience)

  沼知陽太郎, 吉田寿美子, 曽良一郎, 佐藤光源

  2004, Clinical Neuroscience, 693 - 695


• [Study on genes involved in pathogenesis of schizophrenia with DNA microarray] (Seishin Shinkeigaku Zasshi)

  Itokawa Masanari, Arai Makoto, Ujiie Hiroshi, Sora Ichiro, Yoshikawa Takeo, Ikeda Kazuhiko

  2004, Seishin Shinkeigaku Zasshi, 106(1) (1), 42 - 48


• Role of dopaminergic and serotonergic neurotransmission in methamphetamine-induced neurotoxicity and hyperthermia in dopamine and/or serotonin transporter knockout mice

  NUMACHI Yohtaro, OHARA Arihisa, YAMASHITA Motoyasu, OHMI Kayo, FUKUSHIMA Setsu, HATA Harumi, SHEN Hao-wei, KOBAYASHI Hideaki, YAMAMOTO Hideko, IKEDA Kazutaka, SORA Ichiro

  Dec. 2003, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 23(6) (6), 283 - 283, Japanese


• The interaction of dopaminergic and serotonergic nervous systems in prepulse inhibition

  KOBAYASHI Hideaki, YAMASHITA Motoyasu, OHMI Kayo, FUKUSHIMA Setsu, OHARA Arihisa, TOHMI Manabu, SHEN Hao-wei, YAMAMOTO Hideko, IKEDA Kazutaka, NAWA Hiroyuki, NUMACHI Yohtaro, SORA Ichiro

  Dec. 2003, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 23(6) (6), 348 - 348, Japanese


• Fluoxetine increases extracellular dopamine in the prefrontal cortex independently of serotonin transporter

  SHEN Hao-wei, HAGINO Yoko, KOBAYASHI Hideaki, YAMAMOTO Hideko, IKEDA Kazutaka, SORA Ichiro

  Dec. 2003, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 23(6) (6), 299 - 299, Japanese


• オピオイド受容体の分子生物学

  曽良 一郎

  25 Jun. 2003, The journal of the Japan Society of Pain Clinicians = 日本ペインクリニック学会誌, 10(3) (3), 253 - 253, Japanese


• Sex-dependent modulation of ethanol consumption in vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) knockout mice

  FS Hall, Sora, I, GR Uhl

  Apr. 2003, NEUROPSYCHOPHARMACOLOGY, 28(4) (4), 620 - 628, English

  Book review


• Methamphetamine-induced behavioral sensitization in monoamine transporter knockout mice.

  SORA ICHIRO, SHEN H-W, HAGINO YOKO, KOBAYASHI HIDEAKI, IDE SOICHIRO, UHL G R, NUMACHI YOTARO, YAMAMOTO TOSHIFUMI, IKEDA KAZUTAKA

  Mar. 2003, 精神薬療研究年報, 35(35) (35), 127 - 133, Japanese


• Research for comprehensive promotion of brain study. Association analysis of individual difference of analgesic susceptibility and gene sequences of mu-opioid receptor.

  IKEDA KAZUTAKA, HATA HARUMI, IDE SOICHIRO, YAMAMOTO HIDEKO, TAKAMATSU YUKIO, NAKAMURA KAZUHIKO, SORA ICHIRO

  2003, 脳研究の総合的推進に関する研究 平成13年度採択公募班員, 4, Japanese


• Catecholamine and higher neuronal function

  SORA Ichiro, KOBAYASHI Hideaki

  2003, 自律神経 = The Autonomic nervous system, 40(3) (3), 238 - 243, Japanese


• うつと不安の共通因子 (Bulletin of Depression and Anxiety)

  沼知陽太郎, 吉田寿美子, 曽良一郎

  2003, Bulletin of Depression and Anxiety, 8 - 11


• うつと不安の共通因子 (Bulletin of Depression and Anxiety)

  沼知陽太郎, 吉田寿美子, 曽良一郎

  2003, Bulletin of Depression and Anxiety, 8 - 11


• カテコラミントランスポーターと高次神経機能 (自律神経)

  曽良一郎, 小林秀明

  2003, 自律神経, 238 - 243


• Sex-dependent modulation of ethanol consumption in vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) knockout mice.

  Hall F Scott, Sora I, Uhl G R

  Several lines of evidence suggest that monoaminergic systems, especially dopaminergic and serotoninergic systems, modulate ethanol consumption. Humans display significant differences in expression of the vesicular and plasma membrane monoamine transporters important for monoaminergic functions, including the vesicular monoamine transporter (VMAT2, SLC18A2) and dopamine transporter (DAT, SLC6A3). In addition, many ethanol effects differ by sex in both humans and animal models. Therefore, ethanol consumption and preference were compared in male and female wild-type mice, and knockout (KO) mice with deletions of genes for DAT and VMAT2. Voluntary ethanol (2-32% v/v) and water consumption were compared in two-bottle preference tests in wild-type (+/+) vs heterozygous VMAT2 KO mice (+/-) and in wild-type (+/+) vs heterozygous (+/-) or homozygous (-/-) DAT KO mice. Deletions of either the DAT or VMAT2 genes increased ethanol consumption in male KO mice, although these effects were highly dependent on ethanol concentration, while female DAT KO mice had higher ethanol preferences. Thus, lifetime reductions in the expression of either DAT or VMAT2 increase ethanol consumption, dependent on sex.

  2003, Neuropsychopharmacology, 28(4) (4), 620 - 628, English, International magazine


• Opioid receptor coupling to GIRK channels. In vitro studies using a Xenopus oocyte expression system and in vivo studies on weaver mutant mice. (Methods Mol Med)

  Ikeda Kazutaka, Yoshii Mitsunobu, Sora Ichiro, Kobayashi Toru

  2003, Methods Mol Med, 84, 53 - 64


• Receptor knock-out and gene targeting. Generation of knock-out mice. (Methods Mol Med)

  Sora Ichiro, Ikeda Kazutaka, Mishina Yuji

  2003, Methods Mol Med, 84, 205 - 216


• Methamphetamine sensitization in dopamine and/or serotonin transporter knockout mince

  SHEN Hao-wei, HAGINO Yoko, KOBAYASHI Hideaki, R. UHL George, IKEDA Kazutaka, YAMAMOTO Toshifumi, YAMAMOTO Hideko, SORA Ichiro

  25 Dec. 2002, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 22(6) (6), 274 - 274, Japanese


• Reduced of depressive-like behavior in mu opioid receptor knockout mice

  TAKAMATSU Yukio, IKEDA Kazutaka, NIKI Hiroaki, R. UHL George, SORA Ichiro

  25 Dec. 2002, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 22(6) (6), 328 - 328, Japanese


• Dopamine Transporter(DAT)Knockout Mouse(KO)における一酸化窒素(NO)産生量とL‐dopaによる変動

  糸川かおり, 大熊彩, 荒木信夫, 曽良一郎, 池田和隆, UHL G R, 島津邦男

  01 Dec. 2002, 臨床神経学, 42(12) (12), 1328, Japanese


• Molecular Genetics of Mental Disorders Using Transgenic Mouse Model

  SORA I.

  東北医学会, Dec. 2002, 東北医学雑誌, 114(2) (2), 191 - 193, Japanese


• Functions of sigma-1 receptors in the synaptic vesicles of dopaminergic neuron

  YAMAMOTO Hideko, KARASAWA Jun-ichi, YAMAMOTO Toshifumi, NUKADA Toshihide, KAMETANI Fuyuki, IKEDA Kazutaka, SORA Ichiro, YAMAKUNI Tohru, OOIZUMI Yasushi

  Dec. 2002, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 22(6) (6), 258 - 258, Japanese


• ラット中性アミノ酸トランスポーター,ASCT‐1のクローニングとその機能解析

  西崎糸音, 山本秀子, 額田敏秀, 池田和隆, 畑春実, 曽良一郎, 古屋茂樹, 平林義雄, 山本敏文

  25 Aug. 2002, 生化学, 74(8) (8), 747, Japanese


• Molecular genetics of opioid analgesia and reward.

  SORA ICHIRO, IKEDA KAZUTAKA, IDE SOICHIRO, HATA HARUMI, SHINOHARA KEIKO, YAMAMOTO TOSHIFUMI, HALL S, UHL G R, MATSUSHITA MASAAKI

  Mar. 2002, 精神薬療研究年報, (34) (34), 221 - 228, Japanese


• アルコールと脳機能

  池田和隆, 小林徹, 曽良一郎

  日本醸造協会, Feb. 2002, 日本醸造協会誌, 97(2) (2), 124 - 130, Japanese


• 遺伝子改変マウスモデルを用いた依存性薬物の分子作用機序

  曽良一郎, 沈昊偉, 萩野洋子, 小林秀昭, 田中, 篠原, 慶子, 井手聡一郎, Uhl GR, 池田和隆, 山本敏文, 山本秀子

  2002, 厚生科学研究費補助金 (医薬安全総合研究事業) 規制薬物の依存及び神経毒性の発現にかかわる仕組みの分子生物学的解明に関する研究:平成13年度総括研究報告, 73 - 81, Japanese


• Cocaine, reward, movement and monoamine transporters

  GR Uhl, FS Hall, Sora, I

  2002, MOLECULAR PSYCHIATRY, 7(1) (1), 21 - 26, English, International magazine


• 覚せい剤精神病におけるDopamine Transporter(hDAT1)遺伝子の相関研究

  氏家寛, 中田謙二, 高木学, 原野睦生, 小宮山徳太郎, 三ツ汐洋, 関根吉統, 稲田俊也, 前田貴記, 岩下覚, 山田光彦, 曽良一郎, 伊豫雅臣, 尾崎紀夫, JGIDA

  Dec. 2001, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 21(6) (6), 234 - 234, Japanese


• VMAT2に対する抗精神病薬の作用

  唐沢淳一, 山本秀子, 高橋真司, 堀込和利, 山本敏文, 池田和隆, 曽良一郎

  01 Sep. 2001, 神経化学, 40(2/3) (2/3), 431, Japanese


• マウスにおける2つの脳内自己刺激解析方法の比較 ヘッドディッピング法と滞在学習法

  池田和隆, シェルダン モス, ファウラー スティーブン, 曽良一郎, 二木宏明

  01 Sep. 2001, 神経化学, 40(2/3) (2/3), 290, Japanese


• Resistance of PC12 cells against nitric oxide (NO)-induced toxicity in long-term culture: Implication of neuronal NO synthase expression

  Kohei Yuyama, Hideko Yamamoto, Kazuhiro Nakamura, Takeshi Kato, Ichiro Sora, Toshifumi Yamamoto

  31 Aug. 2001, Neuroscience Letters, 309(3) (3), 169 - 172, English, International magazine


• Resistance of PC12 cells against nitric oxide (NO)-induced toxicity in long-term culture: implication of neuronal NO synthase expression

  K Yuyama, H Yamamoto, K Nakamura, T Kato, Sora, I, T Yamamoto

  Aug. 2001, NEUROSCIENCE LETTERS, 309(3) (3), 169 - 172, English


• Knockout mice as model of neuropsychiatric disorders. Behavioral and neurochemical analysis of dopamine & serotonin double knockout mice.

  SORA ICHIRO, YAMAMOTO HIDEKO, HAGINO YOKO, SHINOHARA KEIKO, NONAKA RYOICHI, YAMAMOTO TOSHIFUMI, IKEDA KAZUTAKA, MATSUSHITA MASAAKI

  Mar. 2001, 精神薬療研究年報, (33) (33), 246 - 251, Japanese


• [Study of drug dependence using genetically modified animals] (Nihon Shinkei Seishin Yakurigaku Zasshi)

  Sora I

  2001, Nihon Shinkei Seishin Yakurigaku Zasshi, 21(5) (5), 163 - 164


• [Study of drug dependence using genetically modified animals] (Nihon Shinkei Seishin Yakurigaku Zasshi)

  Sora I

  2001, Nihon Shinkei Seishin Yakurigaku Zasshi, 21(5) (5), 163 - 164, Japanese, Domestic magazine