Research activity information

• Potential of zoledronate for treating diffuse sclerosing osteomyelitis of the mandible in adult patients.

  Junya Kusumoto, Shungo Furudoi, Yumi Muraki, Moeka Warabi, Daisuke Takeda, Masaya Akashi

  INTRODUCTION: Diffuse sclerosing osteomyelitis (DSO) is a rare nonbacterial bone disease associated with recurrent pain and swelling, and its pathogenesis remains unknown. Despite the absence of an established treatment for DSO, bisphosphonates have recently been considered effective in managing this condition. However, the use of zoledronate is off-label, with limited reported cases. Therefore, this study aimed to investigate the effects of zoledronate on pain suppression in DSO. METHODS: This single-arm retrospective study evaluated adult patients diagnosed with mandibular DSO and treated with zoledronate. Patient demographics, pain suppression effect, recurrence, number of zoledronate administration, adverse reactions to zoledronate, and imaging findings were investigated. RESULTS: The study included 18 patients (median age of 59.5 years). Zoledronate effectively suppressed pain in all patients, with a median duration of effect onset of 1 day. Symptom recurrence was observed in 66.7% of patients, with a median time of 29 months from the first zoledronate administration to recurrence. Zoledronate was administered multiple times to 44.7% of patients. The median duration of response was 80 months for patients who experienced relief after a single administration of zoledronate compared to 32 months for those who received multiple administrations (p < 0.001). Adverse reactions, including flu-like symptoms, were observed in 72.2% of the patients, and no medication-related osteonecrosis of the jaw was observed during the follow-up period. CONCLUSIONS: Zoledronate is a relatively safe and effective treatment option for DSO of the mandible. Key Points • Zoledronate effectively suppresses pain in mandibular diffuse sclerosing osteomyelitis. • All condylar lesions recurred after zoledronate administration. • Patients with mandibular canal enlargement required multiple doses of zoledronate. • Adverse reactions to zoledronate administration were minor.

  Apr. 2025, Clinical rheumatology, English, International magazine

  Scientific journal


• Evaluation of Zoledronate for Pain Suppression in Diffuse Sclerosing Osteomyelitis of the Mandible: Protocol for a Prospective, Single-Arm Interventional Study.

  Junya Kusumoto, Shungo Furudoi, Daisuke Takeda, Megumi Kishimoto, Masaya Akashi

  INTRODUCTION: Diffuse sclerosing osteomyelitis (DSO) is a non-bacterial osteomyelitis that occurs infrequently and is characterized by recurrent severe pain, swelling of the mandible, and trismus. To date, no effective treatment has been established. Bisphosphonates have been suggested as an efficacious treatment for DSO; however, no prospective studies have examined the effect of bisphosphonate treatment in adults with DSO. This study aims to evaluate the effect of zoledronate on pain suppression in patients with DSO. METHODS: This is a single-center, exploratory, single-arm, prospective interventional study. The participants will include eight patients with DSO of the mandible. The primary endpoint is the change in pain levels before and after zoledronate administration. The secondary endpoints are assessing the efficacy of the clinical course, imaging changes, and safety monitoring. Patients will be enrolled if they are deemed eligible following screening tests and will receive only one 4.0 mg intravenous dose of zoledronate within seven days of enrollment. Study participants will be followed up at one, four, 12, 24, and 48 weeks post-dose or at discontinuation after zoledronate administration. CONCLUSION: This study is the first prospective trial to evaluate the effect of administering a single dose of zoledronate on pain suppression in patients with DSO. We believe this study will lead to the conclusion that zoledronate is an effective treatment for DSO.

  Mar. 2025, Cureus, 17(3) (3), e80739, English, International magazine

  Scientific journal


• Zymosan-Treated SKG Mice: Assessing Effects of Systemic Inflammation on the Temporomandibular Joint.

  Kaito Uryu, Yasumasa Kakei, Sho Sendo, Ikuko Goto, Kengo Akashi, Keisuke Nishimum, Tatsuya Shirai, Junya Hirota, Daisuke Takeda, Manabu Shigeoka, Akira Kimoto, Takumi Hasegawa, Jun Saegusa, Masaya Akashi

  OBJECTIVES: The effects of systemic inflammation on the temporomandibular joint (TMJ) are poorly understood. This study aimed to establish a mouse model to study the effects of systemic inflammation on the TMJ. MATERIALS AND METHODS: SKG mice, a BALB/c strain with spontaneous onset of rheumatoid arthritis-like symptoms due to a spontaneous point mutation (W163C) in the gene encoding the SH2 domain of ZAP-70, were treated with zymosan (β-1,3-glucan). Synovitis, bone erosion, and cartilage damage in the TMJ were evaluated using established scores for animal models of inflammatory arthritis. Myeloperoxidase-positive areas and numbers of tartrate-resistant acid phosphatase (TRAP)-positive cells were compared between naive and zymosan-treated SKG mice. Correlations between TMJ inflammation scores and clinical scores for extremities were also assessed. RESULTS: There were significant differences in TMJ inflammation scores, including synovitis, bone erosion, and cartilage damage, between naive and high-dose zymosan-treated mice. There were significant differences in myeloperoxidase-positive areas and numbers of TRAP-positive cells between naive and zymosan-treated mice. There were significant correlations between TMJ inflammation scores and clinical scores for extremities. CONCLUSIONS: Systemic administration of zymosan efficiently induces TMJ inflammation in SKG mice. Zymosan-treated SKG mice offer a useful tool to investigate the effects of systemic inflammation on the TMJ.

  Dec. 2024, Oral diseases, English, International magazine

  Scientific journal


• Predictive factors in difficult postoperative airway management of severe odontogenic deep neck infection.

  Eiji Iwata, Go Inokuchi, Masakazu Kawakami, Taiki Matsui, Junya Kusumoto, Akira Tachibana, Masaya Akashi

  In this study, we aimed to identify risk factors that predict the postoperative need for advanced or prolonged airway management in patients with severe odontogenic deep neck infections (DNIs). This retrospective case-control study included patients of both sexes aged ≥ 18 years who had undergone surgical drainage including debridement of necrotic tissues of odontogenic deep neck abscesses and necrotizing soft tissue infection under general anesthesia between April 2016 and September 2023 at a single center. The patients' characteristics, laboratory tests, and computed tomography (CT) findings were analyzed and compared between the difficult postoperative airway group, which required prolonged intubation or tracheostomy, and the short-term intubation group. Statistical significance was set at P < 0.05. Sixty-four patients required surgical drainage including debridement under general anesthesia. Of them, 7 (10.9%) patients were included in the difficult postoperative airway group. In addition to increased inflammatory markers, the presence of arytenoid edema among laryngeal edema and retro- and parapharyngeal space abscesses on preoperative CT images were identified as risk factors. The presence of pharyngeal space abscesses was significantly associated with laryngeal edema, and the intubation period was longer in patients with more elements relevant to these two factors. Thus, the presence of pharyngeal space abscesses and degree of laryngeal edema on preoperative CT images can be used to predict the complexity of postoperative airway management. Our results suggest that tracheostomy is preferable for patients with retropharyngeal space abscesses, and that patients with parapharyngeal space abscesses and laryngeal edema are desirable to undergo prolonged intubation.

  Dec. 2024, Odontology, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Dd診断力てすと 右下顎臼歯部の腫瘤

  筧 康正, 明石 昌也

  (株)デンタルダイヤモンド社, Dec. 2024, DENTAL DIAMOND, 49(16) (16), 19 - 20, Japanese


• Effect of Statins on Patients With Osteoradionecrosis of the Jaw.

  Junya Kusumoto, Yumi Muraki, Akiko Sakakibara, Shungo Furudoi, Masaya Akashi

  BACKGROUND: Osteoradionecrosis of the jaw (ORN) is a late complication of radiation therapy. Radiation-induced fibrosis is the most likely mechanism for developing ORN, and statins are effective against radiation-induced fibrosis. However, no reports have indicated the direct effectiveness of statins in treating ORN. PURPOSE: This study aimed to measure the association between statin exposure and ORN disease resolution. STUDY DESIGN, SETTING, SAMPLE: This retrospective cohort study included patients with ORN diagnosed between January 2008 and December 2020 at the Hospital's Department of Oral and Maxillofacial Surgery. Patients who were immunocompromised or followed up for < 6 months were excluded. PREDICTOR VARIABLE: The predictor variable was statin exposure, which was defined as the use of statins for dyslipidemia. MAIN OUTCOME VARIABLE: The main outcome variable was ORN disease progression status (good prognosis). Patients who showed full recovery and improvement were included in the good prognosis group, and those who showed invariance and deterioration were included in the poor prognosis group. COVARIATES: We analyzed the clinicodemographic including the age of onset, sex, history of smoking, alcohol consumption, history of chemotherapy, tumor site, association with dental treatment, location (maxilla or mandible), the time to ORN onset from radiation therapy, and stage of ORN, and treatment characteristics including hyperbaric oxygen therapy, long-term macrolide administration, and sequestrectomy. ANALYSES: We analyzed the association between statin exposure or covariates and time to ORN improvement using bivariate and multivariate Cox regression. The significance level was set at P = .05. RESULTS: We analyzed 102 patients, and the improvement rate was 32.4%. The favorable prognostic factors were statin exposure (adjusted hazard ratio [HR], 3.71; 95% confidence interval [CI], 1.62 to 8.50; P = .002), onset in the maxilla (HR, 2.15; 95% CI, 1.02 to 4.55; P = .045), and stage 1 of ORN (HR, 2.65; 95% CI, 1.20 to 5.83; P = .016). CONCLUSION AND RELEVANCE: In this study, statin exposure, onset in the maxilla, and stage 1 of Lyons's classification were favorable prognostic factors for ORN. Although this study's findings were insufficient to recommend statin use for ORN, statins may be a novel and effective treatment for ORN.

  Dec. 2024, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 82(12) (12), 1585 - 1595, English, International magazine

  Scientific journal


• Dental dysplasia in childhood cancer survivors: a case series of permanent tooth abnormalities.

  Yumi Muraki, Atsushi Shioyasono, Mika Nishii, Daisuke Takeda, Junya Kusumoto, Masaya Akashi

  PURPOSE: This study was performed to investigate the association of dental dysplasia with childhood cancer. We examined the occurrence of agenesis, microdontia, and enamel changes of permanent teeth in pediatric cancer survivors. METHODS: Seventy-six patients with pediatric cancer and hematologic diseases were referred to our department for the first time from October 2005 to December 2019. Of these, 17 patients who presented for a checkup in our department fulfilled the study criteria and were analyzed. Clinical examinations and panoramic radiographs were performed to investigate dental dysplasia of permanent teeth. A total of 34 developmental abnormalities (18 missing teeth, 16 cases of microdontia) occurred in 5 patients. The patients' medical records were also analyzed to assess the relationships of specific types of dysplasia with the treatment duration and cumulative drug dose administered. RESULTS: All five pediatric cancer survivors had dental dysplasia; all five had tooth agenesis, and four had microdontia. All five patients were < 4 years of age and had undergone high-dose chemotherapy. CONCLUSION: In this study, childhood cancer survivors who received high-dose chemotherapy before age 4 years experienced the dental dysplasia, including tooth agenesis, microdontia. These findings highlight the need for careful dental monitoring and early intervention in pediatric patients undergoing high-dose chemotherapy. CLINICAL TRIAL NUMBER: This research was conducted in accordance with the Declaration of Helsinki and approved by the Medical Ethics Committee of the Medical University of Kobe (protocol code No. B230066, 1 September 2023).

  Nov. 2024, Oral and maxillofacial surgery, 29(1) (1), 9 - 9, English, International magazine

  Scientific journal


• Relationship between bone union and degree of bone marrow fibrosis at resection margins of advanced mandibular ORN.

  Hiroaki Ohori, Eiji Iwata, Chihiro Ichikawa, Manabu Shigeoka, Yoshiaki Tadokoro, Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Masaya Akashi

  BACKGROUND: The pathological evaluation of cancellous bone at resection margins of mandibular osteoradionecrosis (ORN) has not been well elucidated. Here, we developed a unique classification system for evaluating the degree of bone marrow fibrosis, one of most common pathological features, in patients with mandibular ORN, based on which we investigated its relationship with treatment outcome. METHODS: This study included 15 patients who underwent mandibulectomy and free fibula osteocutaneous flap reconstruction. The extent of mandibulectomy was determined, with safety margins of approximately 10 mm from the apparent osteolytic areas on preoperative computed tomography image. Special staining was performed on thin sections from center of the osteolytic areas (medial area) and bilateral resection margins, and the degree of bone marrow fibrosis was evaluated and investigated its relationship with presence of bone union as a treatment outcome. RESULTS: The degree of bone marrow fibrosis of medial area was significantly higher than those of resection margins. Although most resection margins had collagen fibers which indicate severe fibrosis, all transferred fibula flaps achieved bone union. CONCLUSION: When mandibulectomy is performed with safety margins of approximately 10 mm from the apparent osteolytic areas, all transferred fibula flaps achieved bone union regardless of the degree of bone marrow fibrosis at resection margin. In other words, the association between severe bone marrow fibrosis at resection margins and treatment outcome was not seen. CLINICAL RELEVANCE: Setting safety margins of approximately 10 mm may achieve bone union, but further study is needed.

  Nov. 2024, Clinical oral investigations, 28(11) (11), 626 - 626, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 周術期のオーラルマネジメントによる外科感染症の予防 歯とHeartとの関連

  楠元 順哉, 片山 めぐみ, 村木 友美, 明石 昌也

  (一社)日本外科感染症学会, Oct. 2024, 日本外科感染症学会雑誌, 21(1) (1), 198 - 198, Japanese


• The Radiographic Characteristics of Mandibular Wisdom Teeth That Can Cause Severe Deep Neck Infection.

  Eiji Iwata, Junya Kusumoto, Takumi Hasegawa, Akira Tachibana, Masaya Akashi

  PURPOSE: Mandibular wisdom teeth can occasionally cause infections, which can progress to severe deep neck infections (DNIs) including deep neck abscesses or necrotizing soft tissue infections, which are fatal. This study aimed to identify the radiographic characteristics of mandibular wisdom teeth that developed severe DNIs. METHODS: This study included patients who were admitted for the treatment of severe mandibular wisdom tooth infection between July 2012 and June 2024 at a single center. Patient characteristics, clinical data, and radiographic findings were analyzed and compared between the severe DNI group and mild DNI group including patients with cellulitis or superficial abscess. P < 0.05 was considered significant. RESULTS: Nineteen of 42 patients (45.2%) were included in the severe DNI group. The multivariate analysis showed that the highest odds ratio (OR) was for the presence of a radicular cyst (OR=17.7), followed by the presence of a dentigerous cyst (OR =14.5). The most common mandibular wisdom tooth with a dentigerous cyst in patients with severe DNIs was inverted according to Winter's classification and type IIIC in the Pell and Gregory classification. CONCLUSION: Radiographic characteristics associated with severe DNIs included the presence of radicular and dentigerous cysts in the mandibular wisdom teeth. Especially in dentigerous cysts, deeply impacted teeth should be taken attention.

  Oct. 2024, Cureus, 16(10) (10), e70791, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 下顎びまん性硬化性骨髄炎に対してゾレドロン酸は有効な治療薬となりうるか?

  楠元 順哉, 古土井 春吾, 村木 友美, 武田 大介, 明石 昌也

  (NPO)日本口腔科学会, Sep. 2024, 日本口腔科学会雑誌, 73(2) (2), 195 - 195, Japanese


• ヒト下歯槽神経のバリア制御に関連する分子の解析

  平岡 佑二郎, 松村 恵実, 筧 康正, 武田 大介, 重岡 学, 木本 明, 長谷川 巧実, 明石 昌也

  (NPO)日本口腔科学会, Sep. 2024, 日本口腔科学会雑誌, 73(2) (2), 113 - 113, Japanese


• 歯の喪失は65歳高齢者の早期要介護発生リスクと関係するか?

  筧 康正, 白井 達也, 長谷川 巧実, 明石 昌也

  (NPO)日本口腔科学会, Sep. 2024, 日本口腔科学会雑誌, 73(2) (2), 216 - 216, Japanese


• What Is the Appropriate Antibiotic Administration During Tooth Extractions in Patients Receiving High-Dose Denosumab?

  Eiji Iwata, Takumi Hasegawa, Hiroaki Ohori, Toshiya Oko, Tsutomu Minamikawa, Daisuke Miyai, Masaki Kobayashi, Naoki Takata, Shungo Furudoi, Junichiro Takeuchi, Kosuke Matsumoto, Akira Tachibana, Masaya Akashi

  PURPOSE: Medication-related osteonecrosis of the jaw (MRONJ) occasionally occurs following tooth extractions in cancer patients receiving denosumab (Dmab). However, there are currently no established guidelines for perioperative antibiotic administration during tooth extraction in these patients. The primary objective was to develop guidelines for the dose and frequency of antibiotics during tooth extraction by investigating the correlation between the current status of antibiotic administration and the development of MRONJ. METHODS: This study included 68 cancer patients receiving high-dose Dmab who had tooth extractions between 2012 and 2022 at 10 hospitals. The relationship between the way of perioperative antibiotic administration and the development of MRONJ was analyzed. A P-value < .05 was considered significant. RESULTS: There was considerable variability across hospitals and surgeons regarding the type, dosage, and duration of antibiotic administration. Amoxicillin (AMPC) was the most commonly used antibiotic. Focusing exclusively on teeth extracted under AMPC administration, MRONJ developed in 21 out of 123 teeth (17.0%). No significant relationship was found between the development of MRONJ and the dosage or duration of perioperative AMPC administration. CONCLUSION: Perioperative antibiotic administration alone may not be sufficient to prevent MRONJ. Therefore, a single preoperative dose is likely adequate for effective and appropriate AMPC administration. .

  Aug. 2024, Cureus, 16(8) (8), e67237, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Prognostic value of a mandibular canal staging system for primary lesions in patients with lower gingival squamous cell carcinoma: a multicenter, retrospective study

  Nobuhiro Yamakawa, Masaya Okura, Takumi Hasegawa, Mitsunobu Otsuru, Hironori Sakai, Eiji Hirai, Shin Rin, Shin-ichi Yamada, Souichi Yanamoto, Yusuke Yokota, Masahiro Umeda, Hiroshi Kurita, Michihiro Ueda, Masaya Akashi, Tadaaki Kirita

  Springer Science and Business Media LLC, May 2024, International Journal of Clinical Oncology, 29(8) (8), 1122 - 1132

  Scientific journal


• 頸部膿瘍におけるドレナージ術後抜管困難症例の特徴

  岩田 英治, 楠元 順哉, 薄田 友理子, 橘 進彰, 明石 昌也

  (一社)日本有病者歯科医療学会, May 2024, 有病者歯科医療, 33(3) (3), 210 - 211, Japanese


• 重症感染症と歯性感染症を再考する 重症歯性感染症のスクリーニングと起因菌を含めた重症化因子

  楠元 順哉, 明石 昌也

  (一社)日本口腔感染症学会, May 2024, 日本口腔感染症学会雑誌, 31(1) (1), 23 - 31, Japanese


• Efficacy of perioperative oral care management in the prevention of surgical complications in 503 patients after pancreaticoduodenectomy for resectable malignant tumor: A multicenter retrospective analysis using propensity score matching

  Taihei Yamguchi, Kazuyo Mori, Yuka Kojima, Takumi Hasegawa, Junya Hirota, Masaya Akashi, Sakiko Soutome, Masako Yoshimatsu, Hiroshi Nobuhara, Yasuhiro Matsugu, Shinichiro Kato, Yasuyuki Shibuya, Hiroshi Kurita, Shin ichi Yamada, Hirokazu Nakahara

  Apr. 2024, Surgery (United States), 175(4) (4), 1128 - 1133

  Scientific journal


• Efficacy of perioperative oral care management in the prevention of surgical complications in 503 patients after pancreaticoduodenectomy for resectable malignant tumor: A multicenter retrospective analysis using propensity score matching.

  Taihei Yamguchi, Kazuyo Mori, Yuka Kojima, Takumi Hasegawa, Junya Hirota, Masaya Akashi, Sakiko Soutome, Masako Yoshimatsu, Hiroshi Nobuhara, Yasuhiro Matsugu, Shinichiro Kato, Yasuyuki Shibuya, Hiroshi Kurita, Shin-Ichi Yamada, Hirokazu Nakahara

  BACKGROUND: Pancreaticoduodenectomy has been associated with a high mortality rate and significant postoperative morbidity. Recently, perioperative oral care management has been reported to be effective in preventing postoperative pneumonia and surgical site infection. In this study, we examined the effect of perioperative oral care management in reducing complications after pancreaticoduodenectomy, including surgical site infection. METHODS: This retrospective multicenter study included 503 patients who underwent pancreaticoduodenectomy at 8 facilities between January 2014 and December 2016. Among these, 144 received perioperative oral management by dentists and dental hygienists (oral management group), whereas the remaining 359 did not (control group). The oral care management program included oral health instructions, removal of dental calculus, professional mechanical tooth cleaning, removal of tongue coating, denture cleaning, instructions for gargling, and tooth extraction. The participants were matched using propensity scores to reduce background bias. Various factors were examined for correlation with the development of complications. RESULTS: The incidence of organ/space surgical site infection was significantly lower in the oral management group than in the control group (8.0% vs 19.6%, P = .005). Multivariable logistic regression analysis revealed that hypertension and lack of perioperative oral management were independent risk factors for organ/space surgical site infection. Lack of perioperative oral management had an odds ratio of 2.847 (95% confidence interval 1.335-6.071, P = .007). CONCLUSION: Perioperative oral care management reduces the occurrence of surgical site infections after pancreaticoduodenectomy and should be recommended as a strategy to prevent infections in addition to antibiotic use.

  Apr. 2024, Surgery, 175(4) (4), 1128 - 1133, English, International magazine

  Scientific journal


• Assessment of Patient Characteristics Influencing the Analgesic Effects of Ibuprofen Gargle After Mandibular Third Molar Extractions.

  Yasumasa Kakei, Takeshi Ioroi, Keiko Miyakoda, Takahiro Ito, Masahiko Kashin, Tatsuya Shirai, Takumi Hasegawa, Toshiyasu Sakane, Ikuko Yano, Masaya Akashi

  Introduction In our previous work, we investigated the analgesic effects of ibuprofen gargle after mandibular third molar extractions. However, a subsequent detailed review of individual patient data revealed variations in postoperative pain reduction among patients. Consequently, the present study was designed to conduct post-hoc subanalyses that identified factors contributing to variation in the analgesic response to ibuprofen gargle after third molar extractions. Materials and methods This study involved thirty-five Japanese patients from a prior randomized, double-blind, placebo-controlled, crossover study, which focused on the analgesic effects of ibuprofen gargle after mandibular third molar extractions. Participants were categorized as responders (n = 13) and non-responders (n = 22) based on the within-subject difference (ibuprofen-placebo, IP) of visual analog scale (VAS) changes. Baseline characteristics were compared, along with variables, such as age, sex, the reason for extraction, extraction site, Pell Gregory (space and depth) classification, Winter's classification, surgeon's experience, and surgery time. Baseline characteristics predicting responder status were examined using multivariate logistic regression. Results In the univariate analysis, variables such as age, sex, and baseline VAS scores with p-values <0.2 were evaluated using a stepwise approach. This analysis identified age (per -10 years) with an odds ratio of 4.163 (95% confidence interval (CI): 1.170-31.952, p = 0.0233) and sex (female) with an odds ratio of 9.977 (95% CI: 1.336-208.256, p = 0.0213) as significant predictors of responder status. Conclusions In young and female patients, ibuprofen gargle decreased postoperative pain after mandibular third molar extractions.

  Apr. 2024, Cureus, 16(4) (4), e57516, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Differential Photosensitivity of Fibroblasts Obtained from Normal Skin and Hypertrophic Scar Tissues.

  Junya Kusumoto, Masaya Akashi, Hiroto Terashi, Shunsuke Sakakibara

  It is unclear whether normal human skin tissue or abnormal scarring are photoreceptive. Therefore, this study investigated photosensitivity in normal skin tissue and hypertrophic scars. The expression of opsins, which are photoreceptor proteins, in normal dermal fibroblasts (NDFs) and hypertrophic scar fibroblasts (HSFs) was examined. After exposure to blue light (BL), changes in the expression levels of αSMA and clock-related genes, specifically PER2 and BMAL1, were examined in both fibroblast types. Opsins were expressed in both fibroblast types, with OPN3 exhibiting the highest expression levels. After peripheral circadian rhythm disruption, BL induced rhythm formation in NDFs. In contrast, although HSFs showed changes in clock-related gene expression levels, no distinct rhythm formation was observed. The expression level of αSMA was significantly higher in HSFs and decreased to the same level as that in NDFs upon BL exposure. When OPN3 knocked-down HSFs were exposed to BL, the reduction in αSMA expression was inhibited. This study showed that BL exposure directly triggers peripheral circadian synchronization in NDFs but not in HSFs. OPN3-mediated BL exposure inhibited HSFs. Although the current results did not elucidate the relationship between peripheral circadian rhythms and hypertrophic scars, they show that BL can be applied for the prevention and treatment of hypertrophic scars and keloids.

  Feb. 2024, International journal of molecular sciences, 25(4) (4), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Segmental mandibulectomy for mandibular osteoradionecrosis in an older adult with underweight status

  Junya Kusumoto, Yuka Hayase, Yuriko Susukida, Takumi Sato, Akiko Sakakibara, Masaya Akashi

  Jan. 2024, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 36(1) (1), 58 - 63, English

  Scientific journal


• Transcutaneous carbon dioxide suppresses skeletal muscle atrophy in a mouse model of oral squamous cell carcinoma.

  Aki Sasaki, Daisuke Takeda, Hotaka Kawai, Yoshiaki Tadokoro, Aki Murakami, Nanae Yatagai, Satomi Arimoto, Hitoshi Nagatsuka, Masaya Akashi, Takumi Hasegawa

  Cancer cachexia causes skeletal muscle atrophy, impacting the treatment and prognosis of patients with advanced cancer, but no treatment has yet been established to control cancer cachexia. We demonstrated that transcutaneous application of carbon dioxide (CO2) could improve local blood flow and reduce skeletal muscle atrophy in a fracture model. However, the effects of transcutaneous application of CO2 in cancer-bearing conditions are not yet known. In this study, we calculated fat-free body mass (FFM), defined as the skeletal muscle mass, and evaluated the expression of muscle atrophy markers and uncoupling protein markers as well as the cross-sectional area (CSA) to investigate whether transcutaneous application of CO2 to skeletal muscle could suppress skeletal muscle atrophy in cancer-bearing mice. Human oral squamous cell carcinoma was transplanted subcutaneously into the upper dorsal region of nude mice, and 1 week later, CO2 gas was applied to the legs twice a week for 4 weeks and FFM was calculated by bioimpedance spectroscopy. After the experiment concluded, the quadriceps were extracted, and muscle atrophy markers (muscle atrophy F-box protein (MAFbx), muscle RING-finger protein 1 (MuRF-1)) and uncoupling protein markers (uncoupling protein 2 (UCP2) and uncoupling protein 3 (UCP3)) were evaluated by real-time polymerase chain reaction and immunohistochemical staining, and CSA by hematoxylin and eosin staining. The CO2-treated group exhibited significant mRNA and protein expression inhibition of the four markers. Furthermore, immunohistochemical staining showed decreased MAFbx, MuRF-1, UCP2, and UCP3 in the CO2-treated group. In fact, the CSA in hematoxylin and eosin staining and the FFM revealed significant suppression of skeletal muscle atrophy in the CO2-treated group. We suggest that transcutaneous application of CO2 to skeletal muscle suppresses skeletal muscle atrophy in a mouse model of oral squamous cell carcinoma.

  2024, PloS one, 19(4) (4), e0302194, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Gold Nanoparticles Enhance the Tumor Growth-Suppressing Effects of Cetuximab and Radiotherapy in Head and Neck Cancer In Vitro and In Vivo

  Takumi Sato, Yasumasa Kakei, Takumi Hasegawa, Masahiko Kashin, Shun Teraoka, Akinobu Yamaguchi, Ryohei Sasaki, Masaya Akashi

  Introduction: Head and neck squamous cell carcinoma (HNSCC) treatment includes surgery, radiotherapy, and immunotherapy with the aim of eradicating cancer cells without affecting normal tissues. HNSCC expresses epidermal growth factor receptor (EGFR) and cetuximab, an IgG1 monoclonal antibody targeting epidermal growth factor receptor, has been approved for the treatment of HNSCC. However, cetuximab has low reactivity and induces serious side effects. Gold nanoparticles (AuNPs) were reported to enhance the local antitumor effects of radiotherapy without damaging normal cells. Methods and Results: This study investigated the in vitro effects of single and combination therapy with AuNPs (1.0 nM), cetuximab (30 nM), and radiotherapy (4 Gy) on a human HNSCC cell line, HSC-3. Combination treatment of AuNPs + cetuximab + radiotherapy markedly reduced HSC-3 numbers and proliferation and enhanced apoptosis compared with single and double combination treatments. Furthermore, the in vivo combination treatment (AuNPs + cetuximab + radiotherapy) of a xenograft model of HSC-3 cells transplanted into nude mice (BALB/cAJcl-nu/nu) reduced the tumor volume compared with the controls. Scanning electron microscopy demonstrated the presence of AuNPs in tumor tissues and toxicity analysis indicated that AuNPs had no toxic effect on normal tissues. Conclusions: This study showed that AuNPs alone do not have a tumor-suppressing effect, but they sensitize tumors to radiotherapy and bind to cetuximab, leading to enhanced antitumor effects.

  MDPI AG, Dec. 2023, Cancers, 15(23) (23), 5697 - 5697

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Detection of bone marrow edema in differential diagnoses of odontogenic cysts using dual-energy computed tomography.

  Takumi Hasegawa, Satomi Arimoto, Izumi Saito, Nanae Yatagai, Aki Murakami, Aki Sasaki, Yoshiaki Tadokoro, Wakiko Tani, Kiyosumi Kagawa, Masaya Akashi

  PURPOSE: In this study, we prospectively investigated the relationship between bone marrow edema (BME) and odontogenic cysts and explored the possibility of using dual-energy computed tomography (DECT) as an auxiliary tool for the diagnosis of odontogenic cysts. METHODS: This cross-sectional study included 73 patients who underwent the DECT scan and surgery for odontogenic cysts or odontogenic tumors. The virtual noncalcium (VNCa) computed tomography (CT) values and CT values were measured at several sites. The predictor variable was diagnosis, and the other variables included age, sex, and sites. The primary outcome was VNCa CT value. Variables were tested using the chi-square test or the Kruskal-Wallis test. The VNCa CT and CT values were tested using the Scheffe test for multiple comparisons. All variables were analyzed as independent variables affecting the VNCa CT values around the lesion in the multiple regression analysis. RESULT: There were 35 men and 38 women. The mean patient age was 50.0 ± 19.5 years (range: 8-86). The VNCa CT values (- 6.2 ± 34.3) around the lesion in patients with RCs were significantly higher than those in patients with dentigerous cysts (- 44.4 ± 28.6) and odontogenic keratocysts (- 67.3 ± 19.5). In multiple regression analysis, the VNCa CT values around the lesion showed a significant positive correlation with histological results (regression coefficient: - 0.605, P < 0.001). CONCLUSION: The presence of BME is associated with radicular cysts, and DECT can be used as an auxiliary tool for radicular cyst diagnosis.

  Dec. 2023, Oral and maxillofacial surgery, 27(4) (4), 675 - 684, English, International magazine

  Scientific journal


• Tooth Loss as a Predictor of Long-Term Care Requirements in the Elderly: A Study in Kobe City, Japan.

  Yasumasa Kakei, Tatsuo Kagimura, Yasuji Yamamoto, Tohmi Osaki, Hiroyuki Kajita, Shinsuke Kojima, Hisatomo Kowa, Miyuki Kawabata, Takumi Hasegawa, Masaya Akashi, Yoji Nagai

  INTRODUCTION: The Kobe project, which utilizes prospective data from the national health insurance system, focuses on early detection and preventive strategies through the Frail Kenshin health check-up program. Previous research has underscored the correlation between tooth loss and the decline in physical and cognitive functions. In this study, using Kobe project data, we examined the link between remaining teeth and long-term care needs in individuals aged 64-65 years, with primary and secondary objectives involving various health parameters and quality of life. METHODS: We analyzed baseline data from a prospective study conducted alongside the Frail Check program for generally healthy individuals aged 64-65 years to examine the relationship between the number of remaining teeth and various health indicators. This study focused on citizens aged 64-65 years to identify those at risk of needing long-term care by the age of 65 years. RESULTS: Data from 1,530 participants were obtained, excluding eight individuals for specific reasons. At the end of the follow-up period, 41 (2.7%) individuals required support and 15 (1.0%) needed long-term care alone. The data revealed a significant association between the number of remaining teeth and the need for long-term care or support, as demonstrated by the Cochran-Armitage trend test (p<0.001). Although trends were noted for nutrition and total Cognitive Functional Instrument Self scores, they did not reach statistical significance. Additionally, a decrease in the number of remaining teeth was significantly associated with worse European Quality of Life Five Dimensions (EQ-5D-5L) visual analog scale scores, mobility, and regular activities (p<0.001). CONCLUSION: Tooth loss indicates the potential long-term care needs of older adults. Monitoring oral health is crucial for addressing care requirements.

  Dec. 2023, Cureus, 15(12) (12), e49851, English, International magazine

  Scientific journal


• Efficacy and safety of ibuprofen gargle for postoperative pain after mandibular third molar extraction: A phase II, placebo-controlled, double-blind, randomized crossover trial.

  Takeshi Ioroi, Yasumasa Kakei, Takahiro Ito, Tatsuya Shirai, Yutaro Okazaki, Takumi Hasegawa, Masaya Akashi, Ikuko Yano

  OBJECTIVE: This study was designed to evaluate the postoperative efficacy and safety of using an ibuprofen gargle as a pain management strategy for patients who have undergone mandibular third molar extraction. We also ensured that the quality of treatment was not compromised throughout the study. MATERIAL AND METHODS: Patients were randomized in a 1:1 ratio into two groups: the ibuprofen-placebo (IP) group and the placebo-ibuprofen (PI) group. On postoperative Day (POD) 1, the IP group initiated ibuprofen administration, while the PI group started taking placebo. On POD 2, the IP group switched to using placebo, whereas the PI group switched to ibuprofen. From PODs 3-5, both groups were prescribed ibuprofen gargle. The primary endpoint was within-subject visual analog scale (VAS) score before and 5 min after the first use of the ibuprofen or placebo gargle on PODs 1 and 2 (ΔVAS5_ibuprofen  - ΔVAS5_placebo ). The incidence and severity of adverse events were assessed using the Common Terminology Criteria for Adverse Events version 5.0 and a subjective rating scale. RESULTS: This study enrolled 40 patients. The within-subject VAS5 of the IP and PI groups were 1.25 ± 12.0 and -5.26 ± 8.93 mm, respectively. The treatment effect of ibuprofen gargle was -2.01 ± 10.62 mm (p = .246). None of the patients in each group presented with serious adverse events or clinically significant complications (including dry sockets) after extraction. Transient adverse events, such as throat tingling and oral discomfort (grade 1), were observed in each group. CONCLUSION: Ibuprofen gargle was safe but did not provide significant pain relief when used after mandibular third molar extraction.

  Nov. 2023, Clinical and experimental dental research, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Risk factors associated with prognosis of patients with medication-related osteonecrosis of the jaw.

  Yoshiaki Tadokoro, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Satomi Arimoro, Eiji Iwata, Izumi Saito, Junya Kusumoto, Masaya Akashi

  OBJECTIVES: Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse effect of antiresorptive and/or antiangiogenic agents. As the treatment application for MRONJ is controversial, we aimed to identify the risk factors for poor prognosis and to help determine appropriate management. METHODS: This study included 119 patients. Relevant clinical data were obtained for all the patients. In computed tomography images, osteosclerosis, osteolysis, cortical perforation (buccal or lingual), periosteal reaction, and sequestration were evaluated. RESULTS: Multivariate analyses showed statistically significant associations between poor prognosis in patients with MRONJ and conservative treatment alone (hazard ratio [HR] 1.89), osteolysis (HR 4.67), and the absence of sequestration (HR 5.33). CONCLUSIONS: Conservative treatment alone without clear objectives needs to be avoided, and osteolytic change could be the criteria for surgical intervention. As the boundary between the lesion and vital bone is indistinct, we recommend extensive surgery in cases with unpredictable sequestration.

  Nov. 2023, Head & neck, English, International magazine

  Scientific journal


• The Efficacy of Carbon Dioxide Paste in Alleviating Pain in Patients After Neck Dissection: Protocol for a Double-Blinded, Randomized Controlled Trial.

  Yoshiaki Tadokoro, Daisuke Takeda, Izumi Saito, Nanae Yatagai, Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa

  BACKGROUND: Head and neck cancers that cause severe aesthetic and functional disorders normally metastasize to the cervical lymph nodes. Patients with cervical lymph node metastasis are undergoing neck dissection. Shoulder complaints are common after neck dissection, with patients reporting symptoms such as pain, weakness, shoulder droop, and disability. However, no safe and effective treatment is available for this condition at present. We will conduct a double-blinded, randomized controlled trial to evaluate the efficacy of carbon dioxide (CO2) paste in relieving pain in patients after neck dissection. OBJECTIVE: This will be the first clinical study to compare the efficacy of CO2 paste with placebo in relieving postoperative pain in patients who underwent neck dissection. METHODS: We will perform this trial at the Kobe University Hospital in Japan. Patients will be randomized 1:1 into the CO2 paste and control groups. Patients in the CO2 paste group will have the CO2 paste applied to the cervical surface skin for 10 minutes once per day for 14 consecutive days. The primary end point of the study is a change in the visual analog scale (VAS) scores of neck pain from baseline on day 1 (preapplication) to the end of drug application (day 15). Secondary end points include changes in the following parameters from baseline on day 1 to the end of drug application (day 15) or the study (day 29): neck pain VAS score (days 1-29), grip strength (days 1-15 and 1-29), VAS scores for subjective symptoms (the feeling of strangulation, numbness, swelling, and warmth in the neck and shoulder region) for days 1-15 and 1-29, whether the VAS score improved more than 30% (days 1-15), the arm abduction test (days 1-15 and 1-29), shoulder range of motion (abduction and flexion) for days 1-15 and 1-29, occurrence of skin disorders, and occurrence of serious side effects. Periodic monitoring will be conducted for participants during the trial. This study was approved by the certified review board of Kobe University. RESULTS: The intervention commenced in May 2021 and will continue until March 2024. The collected data will provide information on the efficacy of the CO2 paste treatment. The primary end point will be compared using the Wilcoxon test, with the 1-sided significance level set at 5%. Each evaluation item will be summarized. Secondary efficacy end points will be analyzed to provide additional insights into the primary analysis. Findings based on the treatment effects are expected to be submitted for publication in 2025. CONCLUSIONS: This trial will provide exploratory evidence of the efficacy and safety of CO2 paste in relieving pain in patients after neck dissection. TRIAL REGISTRATION: Japan Registry of Clinical Trials (jRCT) identifier: jRCTs051210028; https://jrct.niph.go.jp/en-latest-detail/jRCTs051210028. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/50500.

  Nov. 2023, JMIR research protocols, 12, e50500, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 「日本におけるフルカスタムデバイスの展望(最精度顎再建から咬合再建最適化に向けて)」 遊離腓骨皮弁による下顎再建 過去,現在,これから

  楠元 順哉, 明石 昌也

  (公社)日本口腔外科学会, Nov. 2023, 日本口腔外科学会雑誌, 69(11) (11), 499 - 508, Japanese


• Development of Cu application using dual-energy computed tomography for detecting medication-related osteonecrosis of the jaw.

  Kazuki Shigenaga, Satomi Arimoto, Masahiro Kubo, Takumi Sato, Yujiro Hiraoka, Daisuke Takeda, Takumi Hasegawa, Kiyosumi Kagawa, Masaya Akashi

  INTRODUCTION: The present study developed an application using dual-energy computed tomography (DECT) focused on Cu for detecting medication-related osteonecrosis of the jaw (MRONJ). MATERIALS AND METHODS: First, we performed two types of phantom studies using a Cu wire syringe and pig mandible with Cu wire to detect Cu on DECT. Second, DECT examinations of 44 patients with MRONJ were performed to compare lesion and normal bone sites using single-energy CT, DECT-virtual non-calcium (VNCa), and DECT-Cu applications. Quantitative analyses of VNCa CT and CT values were performed, and a cut-off value was calculated using receiver operating characteristic analysis. Third, we compared the Cu content in the MRONJ and normal bone groups using inductively coupled plasma atomic emission spectroscopy (ICP-AES). RESULTS: The material-specific differences in attenuation between the two different energies enabled the accurate separation of Cu from Ca in phantom studies. The sensitivity and specificity for single-energy CT, DECT-VNCa, and DECT-Cu applications were 97.7% and 2.3%, 86.4% and 81.8%, and 88.6% and 97.7%, respectively. Thus, VNCa CT values obtained on DECT-Cu application images showed the highest area under the curve value and maximal diagnostic efficacy in differentiating lesion sites from normal bone sites. On ICP-AES analyses, the Cu content was significantly higher in the MRONJ group than in the normal bone group. CONCLUSION: DECT-Cu application demonstrated better diagnostic performance in detecting MRONJ compared with single-energy CT or DECT-VNCa.

  Nov. 2023, Journal of bone and mineral metabolism, 41(6) (6), 865 - 876, English, Domestic magazine

  Scientific journal


• 当科における口腔癌癌患者の下顎の広範囲顎骨支持型装置に際し口腔前庭拡張術を要した11例

  高木 ひかる, 筧 康正, 白井 達也, 平岡 佑二郎, 有本 智美, 武田 大介, 木本 明, 長谷川 巧実, 明石 昌也

  (公社)日本顎顔面インプラント学会, Nov. 2023, Japanese Journal of Maxillo Facial Implants, 22(3) (3), 242 - 242, Japanese


• Photodynamic therapy with verteporfin accelerates apoptotic bleb formation in human ameloblastoma.

  Junya Yamashita, Akira Kimoto, Shun Teraoka, Yujiro Hiraoka, Daisuke Takeda, Yasumasa Kakei, Manabu Shigeoka, Takumi Hasegawa, Masaya Akashi

  OBJECTIVE: Although benign, ameloblastoma is a locally aggressive lesion in some patients and the development of additional treatments is needed. Verteporfin (VP) is a photosensitizer exhibiting considerable photocytotoxicity in various tumor cells. We aimed to investigate the effects of verteporfin photodynamic therapy (VP PDT) on ameloblastoma. METHODS: Eighteen patients who underwent surgery for ameloblastoma were randomly selected. We performed an immunohistochemical assessment to investigate the expression of low-density lipoprotein receptor (LDLR) and Yes-associated protein (YAP), targets of VP, in human ameloblastoma tissues and cultured human ameloblastoma cell line (HAM1). The effect of VP PDT on cell proliferation and apoptosis in HAM1 was analyzed. RESULTS: The expression of LDLR and YAP were detected in human ameloblastoma tissues and HAM1. LDLR expression was significantly higher in patients who had previously undergone surgery than in patients who were receiving it for the first time. The cytotoxic effect of the combination of low-concentration VP administration and laser irradiation was comparable to high-concentration VP administration with and without laser irradiation. The addition of laser irradiation to VP administration significantly accelerated apoptotic bleb formation compared with VP administration alone. CONCLUSION: VP PDT has the potential to become an additional treatment for large-sized ameloblastoma.

  Corresponding, Oct. 2023, Oral diseases, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Correction to: Denosumab-related osteonecrosis of the jaw after tooth extraction and the effects of a short drug holiday in cancer patients: a multicenter retrospective study (Osteoporosis International, (2021), 32, 11, (2323-2333), 10.1007/s00198-021-05995-3)

  T. Hasegawa, N. Ueda, Si Yamada, S. Kato, E. Iwata, S. Hayashida, Y. Kojima, M. Shinohara, I. Tojo, H. Nakahara, T. Yamaguchi, T. Kirita, H. Kurita, Y. Shibuya, S. Soutome, M. Akashi

  Oct. 2023, Osteoporosis International, 34(10) (10), 1823 - 1825

  Scientific journal


• Comparison of the 8th edition of TNM staging of oral cancer with the 7th edition and its prognostic significance using clinical depth of invasion and extranodal extension

  Yusuke Yokota, Takumi Hasegawa, Nobuhiro Yamakawa, Shin Rin, Mitsunobu Otsuru, Shin-ichi Yamada, Eiji Hirai, Yuichi Ashikaga, Kozo Yamamoto, Michihiro Ueda, Tadaaki Kirita, Masahiro Umeda, Masaya Akashi, Hiroshi Kurita, Yoichi Ohiro, Souichi Yanamoto, Masaya Okura

  Elsevier BV, Oct. 2023, Oral Oncology, 145, 106519 - 106519

  Scientific journal


• Correction: Is the LRINEC score useful for predicting necrotizing fasciitis as a complication of MRONJ?

  Eiji Iwata, Junya Kusumoto, Yuriko Susukida, Taiki Matsui, Naoki Takata, Takumi Hasegawa, Akira Tachibana, Masaya Akashi

  Sep. 2023, Journal of bone and mineral metabolism, 41(5) (5), 652 - 653, English, Domestic magazine


• Effect of Frequent Computed Tomography Examinations with Contrast Media on the Renal Function of Patients with Oral Squamous Cell Cancer and an Evaluation of Risk Factors for Post-Operative Chronic Kidney Disease

  Takumi Hasegawa, Aya Matsuda, Rika Amano, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akira Kimoto, Akiko Sakakibara, Masaya Akashi

  Sep. 2023, JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Relationship of Mitochondrial-Related Protein Expression with the Differentiation, Metastasis, and Poor Prognosis of Oral Squamous Cell Carcinoma.

  Aki Murakami, Daisuke Takeda, Junya Hirota, Izumi Saito, Rika Amano-Iga, Nanae Yatagai, Satomi Arimoto, Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa

  Mitochondrial dysfunction and respiratory function changes have been consistently associated with the initiation and progression of cancer. The purpose of this study was to retrospectively investigate the expression of mitochondrial tumor-suppressor and DNA-repair proteins in patients with oral squamous cell carcinoma (OSCC) and to evaluate the relationship between their expression and prognosis. We enrolled 197 patients with OSCC who underwent surgical resection between August 2013 and October 2018. Clinical, pathological, and epidemiological data were retrospectively collected from hospital records. The expression of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), mitochondrial transcription factor A, mitochondrial tumor suppressor gene 1, silent information regulator 3, and 8-hydroxyguanine DNA glycosylase was investigated using immunochemistry. The 3-year disease-specific survival (DSS) rates of patients showing positive expression of all selected proteins were significantly higher than those of patients showing a lack of expression. Multivariate analysis revealed that the expression of PGC-1α (hazard ratio, 4.684) and vascular invasion (hazard ratio, 5.690) can predict the DSS rate (p < 0.001). Low PGC-1α expression and vascular invasion are potential clinically effective predictors of the prognosis of OSCC.

  Aug. 2023, Cancers, 15(16) (16), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Author Correction: Risk factors for pathological fracture in patients with mandibular osteoradionecrosis.

  Hiroaki Ohori, Eiji Iwata, Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Masaya Akashi

  Jul. 2023, Scientific reports, 13(1) (1), 11216 - 11216, English, International magazine


• A Novel Imaging Technique for Analyzing Condylar Movement During Mastication in Patients With Jaw Deformities: Four-Dimensional Computed Tomography.

  Akira Kimoto, Junya Yamashita, Hiroaki Ohori, Noriyuki Negi, Toshinori Sekitani, Hiroki Komori, Atsushi Shioyasono, Chizu Tateishi, Takumi Hasegawa, Masaya Akashi

  OBJECTIVE: This study aimed to reveal characteristic condylar movements in patients with jaw deformities. STUDY DESIGN: Thirty patients with jaw deformities before surgery were enrolled and instructed to chew a cookie during 4-dimensional computed tomography (4DCT). The distance between the most anterior and posterior positions of the bilateral condyles on 4DCT images was measured and compared among patients with different skeletal classes. Correlations between the condylar protrusion and cephalometric values were also determined. RESULTS: The distances of condylar protrusion during mastication were significantly greater in the skeletal class II group than in the skeletal class III group (P=0.0002). Significant correlations were found between the distances of condylar protrusion during mastication and the sella-nasion-B point angle (r=-0.442, P=0.015), A point-nasion-B point angle (r=0.516, P=0.004), sella-nasion plane to ramus plane angle (r=0.464, P=0.01), sella-nasion plane to occlusal plane angle (r=0.367, P=0.047), and condylion-gonion length (r=-0.366, P=0.048). CONCLUSION: Motion analysis with 4DCT images revealed that condylar movement in patients with retrognathism was larger than in patients with mandibular prognathism. Skeletal structure was therefore correlated with condylar movement during mastication.

  Jul. 2023, The Journal of craniofacial surgery, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• LRINEC scoreは薬剤関連顎骨壊死の合併症としての壊死性筋膜炎の予測に有用か?

  岩田 英治, 楠元 順哉, 薄田 友理子, 橘 進彰, 明石 昌也

  (一社)日本有病者歯科医療学会, Jul. 2023, 有病者歯科医療, 32(4) (4), 191 - 192, Japanese


• TruMatch Reconstruction Systemを用いて行った遊離腓骨皮弁による下顎再建の特徴

  蓮井 友統, 楠元 順哉, 早瀬 悠夏, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2023, 日本口腔科学会雑誌, 72(2) (2), 123 - 123, Japanese


• OHATスコアは膿胸患者の3ヵ月時死亡リスク評価に有用である 傾向スコアマッチング法を用いた後ろ向き観察研究

  岩田 英治, 橘 進彰, 八谷 奈苗, 松井 太輝, 楠元 順哉, 長谷川 巧実, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2023, 日本口腔科学会雑誌, 72(2) (2), 158 - 158, Japanese


• 経皮的炭酸ガスペーストによるラット筋損傷モデルにおける瘢痕化防止と筋再生促進効果

  廣田 純也, 長谷川 巧実, 伊賀 利香, 八谷 奈苗, 黒澤 泉, 武田 大介, 筧 康正, 木本 明, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2023, 日本口腔科学会雑誌, 72(2) (2), 166 - 166, Japanese


• Incidence of antiresorptive agent-related osteonecrosis of the jaw: A multicenter retrospective epidemiological study in Hyogo Prefecture, Japan

  Masanori Nashi, Hiromitsu Kishimoto, Masaki Kobayashi, Akira Tachibana, Motoo Suematsu, Shigeyoshi Fujiwara, Yoshiyuki Ota, Susumu Hashitani, Takeshi Shibatsuji, Tetsuya Nishida, Kazuma Fujimura, Shungo Furudoi, Yoshiki Ishida, Shoichiro Ishii, Tsuyoshi Fujita, Soichi Iwai, Takashi Shigeta, Takeshi Harada, Daisuke Miyai, Daisuke Takeda, Masaya Akashi, Kazuma Noguchi, Toshihiko Takenobu

  Jul. 2023, JOURNAL OF DENTAL SCIENCES, 18(3) (3), English

  Scientific journal


• Expression of JCAD and EGFR in Perineurial Cell-Cell Junctions of Human Inferior Alveolar Nerve.

  Yujiro Hiraoka, Megumi Matsumura, Yasumasa Kakei, Daisuke Takeda, Manabu Shigeoka, Akira Kimoto, Takumi Hasegawa, Masaya Akashi

  Although perineurium has an important role in maintenance of the blood-nerve barrier, understanding of perineurial cell-cell junctions is insufficient. The aim of this study was to analyze the expression of junctional cadherin 5 associated (JCAD) and epidermal growth factor receptor (EGFR) in the perineurium of the human inferior alveolar nerve (IAN) and investigate their roles in perineurial cell-cell junctions using cultured human perineurial cells (HPNCs). In human IAN, JCAD was strongly expressed in endoneurial microvessels. JCAD and EGFR were expressed at various intensities in the perineurium. In HPNCs, JCAD was clearly expressed at cell-cell junctions. EGFR inhibitor AG1478 treatment changed cell morphology and the ratio of JCAD-positive cell-cell contacts of HPNCs. Therefore, JCAD and EGFR may have a role in the regulation of perineurial cell-cell junctions.

  Corresponding, Jun. 2023, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 71(6) (6), 221554231182193 - 221554231182193, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Is the LRINEC score useful for predicting necrotizing fasciitis as a complication of MRONJ?

  Eiji Iwata, Junya Kusumoto, Yuriko Susukida, Taiki Matsui, Naoki Takata, Takumi Hasegawa, Akira Tachibana, Masaya Akashi

  INTRODUCTION: Necrotizing fasciitis as a complication of medication-related osteonecrosis of the jaw (MRONJ), which we named "ONJ-NF", has been sometimes reported. This study aimed to investigate the usefulness of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score for predicting ONJ-NF. MATERIALS AND METHODS: We included patients with acute MRONJ who required hospitalization at a single institution from April 2013 to June 2022. They were divided into two groups: patients with ONJ-NF and those with severe cellulitis as a complication of MRONJ, which we named "ONJ-SC." LRINEC scores were compared between the groups and the cut-off value of the score was set by creating a receiver operating characteristic curve. RESULTS: Eight patients with ONJ-NF and 22 patients with ONJ-SC were included. The LRINEC score was significantly higher in patients with ONJ-NF (median: 8.0 points, range 6-10 points) than in those with ONJ-SC (median: 2.5 points, range 0-6 points). A LRINEC score of ≥ 6 points had a sensitivity of 100.0%, a specificity of 77.3%, and an area under the curve of 0.97. Among 6 parameters of LRINEC score, only C-reactive protein (CRP) and white blood cell count (WBC) had significant differences between two groups. Most of the patients with ONJ-NF were rescued by antibiotic therapy and surgical drainage including debridement of necrotic tissues, but unfortunately, one patient did not survive. CONCLUSION: Our results suggested that the LRINEC score may be a useful diagnostic tool to predict ONJ-NF but valuating only CRP and WBC may be sufficient particularly in patients with osteoporosis.

  Jun. 2023, Journal of bone and mineral metabolism, English, Domestic magazine

  Scientific journal


• 埋伏歯の開窓牽引中に生じた頸部膿瘍の1例

  八谷 奈苗, 橘 進彰, 薄田 友理子, 船原 隆一郎, 岩田 英治, 松井 太輝, 楠元 順哉, 明石 昌也

  (一社)日本口腔感染症学会, May 2023, 日本口腔感染症学会雑誌, 30(1) (1), 68 - 69, Japanese


• ステージ1-2舌癌におけるT分類第8版の妥当性の検証と後発頸部リンパ節転移の予測因子

  船原 隆一郎, 古川 浩平, 松井 太輝, 長谷川 巧実, 梅田 正博, 明石 昌也

  (公社)日本口腔外科学会, May 2023, 日本口腔外科学会雑誌, 69(5) (5), 233 - 240, Japanese


• 当科で新型コロナウイルス感染症に対してPCR検査を行った患者についての考察

  利川 誠将, 武田 大介, 長谷川 巧実, 明石 昌也

  (一社)日本口腔感染症学会, May 2023, 日本口腔感染症学会雑誌, 30(1) (1), 65 - 66, Japanese


• 頭頸部粘膜悪性黒色腫に対する陽子線治療+adjuvant Nivolumab療法

  瓜生 開人, 出水 祐介, 窪田 光, 美馬 正幸, 福光 延吉, 今村 善宣, 明石 昌也, 副島 俊典

  (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 234 - 234, Japanese


• ダプトマイシンの長期投与が奏功したMRSA感染を伴う放射線性下顎骨骨髄炎の1例

  西川 華子, 古土井 春吾, 伊賀 利香, 黒澤 泉, 筧 康正, 明石 昌也

  (一社)日本口腔感染症学会, May 2023, 日本口腔感染症学会雑誌, 30(1) (1), 60 - 60, Japanese


• Four-Dimensional Computed Tomographic Image Evaluation of the Change of Condylar Movement With and Without Implant-Supported Removable Prostheses in the Fibular Mandible: A Pilot Case Series Report.

  Junya Yamashita, Kazunobu Hashikawa, Yasumasa Kakei, Toshinori Sekitani, Masaya Akashi

  Implant-supported removable prostheses (ISrP) improve the quality of life, especially in patients who underwent mandibular reconstruction, but few studies have focused on the effect of ISrP in the fibular mandible on the function of the temporomandibular joint. The purpose of this pilot case series was to determine the usefulness of four-dimensional computed tomography (4DCT) images for the evaluation of differences in condylar movements with and without ISrP. Three patients who underwent ISrP following segmental mandibulectomy and free-flap reconstruction were evaluated. The participants were instructed to masticate a cookie during the 4DCT scan. The distance between the most anterior and posterior positions of the condyles on the sagittal view of the 4DCT images during the chewing of the cookies was measured and compared with and without ISrP. 4DCT revealed changes in the distances of condylar protrusion with and without wearing ISrP, but there were no obvious differences among the three patients. The 4DCT motion analysis was useful for the evaluation of the effect of wearing ISrP on condylar movements during mastication in patients with mandibular reconstruction and may become a useful objective evaluation method for the functional evaluation of ISrP.

  Corresponding, May 2023, Cureus, 15(5) (5), e39419, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 歯科衛生士が口腔衛生管理を行った患者に対するCOVID-19発症状況について

  岡崎 葉菜, 武田 大介, 片山 めぐみ, 西井 美佳, 村木 友美, 長谷川 巧実, 明石 昌也

  (一社)日本口腔ケア学会, Apr. 2023, 日本口腔ケア学会雑誌, 17(3) (3), 172 - 172, Japanese


• COVID-19感染が契機と考えられたスティーブンスジョンソン症候群患者への口腔衛生管理の1例

  片山 めぐみ, 村木 友美, 岡崎 葉菜, 西井 美佳, 武田 大介, 長谷川 巧実, 明石 昌也

  (一社)日本口腔ケア学会, Apr. 2023, 日本口腔ケア学会雑誌, 17(3) (3), 229 - 229, Japanese


• Local application of a transcutaneous carbon dioxide paste prevents excessive scarring and promotes muscle regeneration in a bupivacaine-induced rat model of muscle injury

  Junya Hirota, Takumi Hasegawa, Atsuyuki Inui, Daisuke Takeda, Rika Amano-Iga, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Masaya Akashi

  Apr. 2023, INTERNATIONAL WOUND JOURNAL, 20(4) (4), 1151 - 1159, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Local application of a transcutaneous carbon dioxide paste prevents excessive scarring and promotes muscle regeneration in a bupivacaine-induced rat model of muscle injury.

  Junya Hirota, Takumi Hasegawa, Atsuyuki Inui, Daisuke Takeda, Rika Amano-Iga, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Masaya Akashi

  In postoperative patients with head and neck cancer, scar tissue formation may interfere with the healing process, resulting in incomplete functional recovery and a reduced quality of life. Percutaneous application of carbon dioxide (CO2 ) has been reported to improve hypoxia, stimulate angiogenesis, and promote fracture repair and muscle damage. However, gaseous CO2 cannot be applied to the head and neck regions. Previously, we developed a paste that holds non-gaseous CO2 in a carrier and can be administered transdermally. Here, we investigated whether this paste could prevent excessive scarring and promote muscle regeneration using a bupivacaine-induced rat model of muscle injury. Forty-eight Sprague Dawley rats were randomly assigned to either a control group or a CO2 group. Both groups underwent surgery to induce muscle injury, but the control group received no treatment, whereas the CO2 group received the CO2 paste daily after surgery. Then, samples of the experimental sites were taken on days 3, 7, 14, and 21 post-surgery to examine the following: (1) inflammatory (interleukin [IL]-1β, IL-6), and transforming growth factor (TGF)-β and myogenic (MyoD and myogenin) gene expression by polymerase chain reaction, (2) muscle regeneration with haematoxylin and eosin staining, and (3) MyoD and myogenin protein expression using immunohistochemical staining. Rats in the CO2 group showed higher MyoD and myogenin expression and lower IL-1β, IL-6, and TGF-β expression than the control rats. In addition, treated rats showed evidence of accelerated muscle regeneration. Our study demonstrated that the CO2 paste prevents excessive scarring and accelerates muscle regeneration. This action may be exerted through the induction of an artificial Bohr effect, which leads to the upregulation of MyoD and myogenin, and the downregulation of IL-1β, IL-6, and TGF-β. The paste is inexpensive and non-invasive. Thus, it may be the treatment of choice for patients with muscle damage.

  Apr. 2023, International wound journal, 20(4) (4), 1151 - 1159, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Risk factors for pathological fracture in patients with mandibular osteoradionecrosis.

  Hiroaki Ohori, Eiji Iwata, Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Masaya Akashi

  Osteoradionecrosis (ORN) often results in pathological fractures through progression. We aimed to identify the risk factors for pathological fracture in patients with mandibular ORN. Seventy-four patients with mandibular ORN were included in this retrospective study. We investigated various risk factors for pathological fracture in patients with mandibular ORN, including number of mandibular teeth with a poor prognosis each at initial evaluation before radiation therapy (RT) and when fracture occurred, and the proportion of antibiotic administration period in a follow-up duration after RT. The rate of occurrence of pathological fractures in patients with mandibular ORN was 25.7%. The median of duration between RT completion and fracture occurrence was 74.0 months. We found that pathological fracture was significantly associated with a larger number of mandibular teeth with a poor prognosis at initial evaluation before RT (P = 0.024) and when fracture occurred (P = 0.009). Especially, a larger number of mandibular teeth with P4 periodontitis, in other words severe periodontal status, was related to pathological fracture in both timings. The proportion of antibiotic administration period in a follow-up duration was also significant risk factor (P = 0.002). Multivariate analyses showed statistically significant associations between pathological fracture and a larger number of mandibular teeth with a poor prognosis when fracture occurred (hazard ratio 3.669). The patient with a larger number of mandibular teeth with P4 periodontitis may have a risk of not only occurrence of ORN but resulting in pathological fracture by accumulation of infection. Surgeons should consider extraction of those teeth regardless of before/after RT if necessary for infection control.

  Apr. 2023, Scientific reports, 13(1) (1), 5367 - 5367, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Multicenter retrospective study of the prognosis and the effect of postoperative adjuvant therapy in Japanese oral squamous cell carcinoma patients with close margin.

  Takumi Hasegawa, Yasumasa Kakei, Nobuhiro Yamakawa, Tadaaki Kirita, Masaya Okura, Tomofumi Naruse, Mitsunobu Otsuru, Shin-Ichi Yamada, Hiroshi Kurita, Eiji Hirai, Shin Rin, Michihiro Ueda, Masahiro Umeda, Masaya Akashi

  BACKGROUND: The purpose of this retrospective study was to investigate the prognosis of patients with oral cavity cancer with positive margin (PM) or close margin (CM) divided into pN- and pN+ groups. METHODS: The evaluated endpoints were local control and disease-specific survival (DSS) rates. RESULTS: Higher T classification, lymphovascular space invasion (LVSI), and older age were significant risk factors for DSS in the pN- groups. On the other hand, extranodal extension, multiple lymph node metastases, and LVSI were significant risk factors for DSS in the pN+ groups. Among the CM pN+ patients, no significant differences in the 3-year DSS were observed between the only surgery (51.9%) and adjuvant groups (53.2%). CONCLUSIONS: Higher T classification and LVSI are high-risk features more than PM or CM in the pN- groups for DSS. However, further prospective studies are needed to demonstrate the usefulness of adjuvant treatment in patients with PM or CM.

  Mar. 2023, Head & neck, 45(6) (6), 1418 - 1429, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Efficacy and Long-Term Safety of Ibuprofen Gargle for Oral Lichen Planus: A Study Protocol of Randomized Crossover and Long-Term Extension Trials

  Yumi Kitahiro, Takeshi Ioroi, Yasumasa Kakei, Junya Yamashita, Akira Kimoto, Takumi Hasegawa, Asami Morioka, Kazuhiro Yamamoto, Masaya Akashi, Ikuko Yano

  Oral lichen planus (OLP) is a type of chronic and refractory stomatitis characterized by abnormal keratinization, which is often painful. There is no consensus regarding treatment options for OLP, particularly in the presence of pain. The current study protocol focuses on the short-term efficacy and long-term safety of an ibuprofen gargle for pain management in patients with OLP. Patients (n = 24) with painful OLP will be enrolled. During a crossover study period, patients in the ibuprofen–placebo (IP) group will receive an ibuprofen gargle (0.6%) on day 1, a placebo gargle on day 2, and an ibuprofen gargle on days 3–5 at least once daily. Patients in the placebo–ibuprofen (PI) group will receive a placebo gargle on day 1, an ibuprofen gargle on day 2, and an ibuprofen gargle on days 3–5 at least once daily. The primary endpoint of the crossover study period is the change in pain level as measured by a visual analogue scale score from before gargle administration to 5 min after gargle administration on days 1 and 2. The primary endpoint of the long-term extension study is assessment of long-term safety. The results of this study may support existing evidence regarding the effectiveness of ibuprofen rinses in treating OLP.

  MDPI AG, Jan. 2023, Methods and Protocols, 6(1) (1), 7 - 7

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Transcutaneous carbon dioxide application suppresses the expression of cancer-associated fibroblasts markers in oral squamous cell carcinoma xenograft mouse model.

  Yoshiaki Tadokoro, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa

  Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Cancer-associated fibroblasts (CAFs) are the main stromal cells in the tumor microenvironment (TME). As CAFs promote tumor progression and hypoxia in the TME, regulating the conversion of normal fibroblasts (NFs) into CAFs is essential for improving the prognosis of patients with OSCC. We have previously reported the antitumor effects of transcutaneous carbon dioxide (CO2) application in OSCC. However, the effects of reducing hypoxia in the TME remain unclear. In this study, we investigated whether CO2 administration improves the TME by evaluating CAFs marker expression. Human OSCC cells (HSC-3) and normal human dermal fibroblasts (NHDF) were coinjected subcutaneously into the dorsal region of mice. CO2 gas was applied twice a week for 3 weeks. The tumors were harvested six times after transcutaneous CO2 application. The expression of CAFs markers (α-SMA, FAP, PDPN, and TGF-β) were evaluated by using real-time polymerase chain reaction and immunohistochemical staining. The expression of α-SMA, FAP, PDPN, and TGF-β was significantly increased over time after co-injection. In the CO2-treated group, tumor growth was significantly suppressed after treatment initiation. In addition, the mRNA expression of these markers was significantly inhibited. Furthermore, immunohistochemical staining revealed a significant decrease in the protein expression of all CAFs markers in the CO2-treated group. We confirmed that transcutaneous CO2 application suppressed CAFs marker expression and tumor growth in OSCC xenograft mouse model.

  2023, PloS one, 18(8) (8), e0290357, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Relationship between oral health and prognosis in patients with empyema: Single center retrospective study with propensity score matching analysis.

  Eiji Iwata, Teruaki Nishiuma, Suya Hori, Keiko Sugiura, Masato Taki, Shuntaro Tokunaga, Junya Kusumoto, Takumi Hasegawa, Akira Tachibana, Masaya Akashi

  BACKGROUND: Empyema is a life-threatening infection often caused by oral microbiota. To the best of our knowledge, no reports have investigated the association between the objective assessment of oral health and prognosis in patients with empyema. MATERIALS AND METHODS: A total of 63 patients with empyema who required hospitalization at a single institution were included in this retrospective study. We compared non-survivors and survivors to assess risk factors for death at three months, including the Renal, age, pus, infection, diet (RAPID) score, and Oral Health Assessment Tool (OHAT) score. Furthermore, to minimize the background bias of the OHAT high-score and low-score groups determined based on the cut-off value, we also analyzed the association between the OHAT score and death at 3 months using the propensity score matching method. RESULTS: The 3-month mortality rate was 20.6% (13 patients). Multivariate analysis showed that a RAPID score ≥5 points (odds ratio (OR) 8.74) and an OHAT score ≥7 points (OR 13.91) were significantly associated with death at 3 months. In the propensity score analysis, a significant association was found between a high OHAT score (≥7 points) and death at 3 months (P = 0.019). CONCLUSION: Our results indicated that oral health assessed using the OHAT score may be a potential independent prognostic factor in patients with empyema. Similar to the RAPID score, the OHAT score may become an important indicator for the treatment of empyema.

  2023, PloS one, 18(3) (3), e0282191, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Hematologic and inflammatory parameters for determining severity of odontogenic infections at admission: a retrospective study.

  Junya Kusumoto, Eiji Iwata, Wensu Huang, Naoki Takata, Akira Tachibana, Masaya Akashi

  BACKGROUND: Severe odontogenic infections in the head and neck region, especially necrotizing soft tissue infection (NSTI) and deep neck abscess, are potentially fatal due to their delayed diagnosis and treatment. Clinically, it is often difficult to distinguish NSTI and deep neck abscess in its early stage from cellulitis, and the decision to perform contrast-enhanced computed tomography imaging for detection is often a challenge. This retrospective case-control study aimed to examine the utility of routine blood tests as an adjunctive diagnostic tool for NSTI in the head and neck region and deep neck abscesses. METHODS: Patients with severe odontogenic infections in the head and neck region that required hospitalization were classified into four groups. At admission, hematologic and inflammatory parameters were calculated according to the blood test results. In addition, a decision tree analysis was performed to detect NSTI and deep neck abscesses. RESULTS: There were 271 patients, 45.4% in Group I (cellulitis), 22.5% in Group II (cellulitis with shallow abscess formation), 27.3% in Group III (deep neck abscess), and 4.8% in Group IV (NSTI). All hematologic and inflammatory parameters were higher in Groups III and IV. The Laboratory Risk Indicator for Necrotizing Fasciitis score, with a cut-off value of 6 and C-reactive protein (CRP) + the neutrophil-to-lymphocyte ratio (NLR), with a cut-off of 27, were remarkably useful for the exclusion diagnosis for Group IV. The decision tree analysis showed that the systemic immune-inflammation index (SII) of ≥ 282 or < 282 but with a CRP + NLR of ≥ 25 suggests Group III + IV and the classification accuracy was 89.3%. CONCLUSIONS: Hematologic and inflammatory parameters calculated using routine blood tests can be helpful as an adjunctive diagnostic tool in the early diagnosis of potentially fatal odontogenic infections. An SII of ≥ 282 or < 282 but with a CRP + NLR of ≥ 25 can be useful in the decision-making for performing contrast-enhanced computed tomography imaging.

  Dec. 2022, BMC infectious diseases, 22(1) (1), 931 - 931, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Perioperative bridging anticoagulation in patients with oral cancer surgery: a multicenter retrospective study

  Ryo Kajihara, Shin ichi Yamada, Takumi Hasegawa, Hitoshi Yoshimura, Hidetake Tachinami, Kei Tomihara, On Hasegawa, Sumiyo Hishida, Nobuhiro Ueda, Kenjiro Okamoto, Sakiko Soutome, Yuya Denda, Masaaki Miyakoshi, Kiriko Matsuzawa, Eiji Kondo, Yoshimasa Kitagawa, Daichi Chikazu, Yoshihide Ota, Yasuyuki Shibuya, Masaya Akashi, Tatsushi Matsumura, Masahiro Umeda, Tadaaki Kirita, Makoto Noguchi, Hiroshi Kurita

  Nov. 2022, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 34(6) (6), 734 - 739


• 当科における口腔癌患者の広範囲顎骨支持型装置の成功率に関する後ろ向き観察研究

  早瀬 悠夏, 長谷川 巧実, 白井 達也, 平岡 佑二郎, 有本 智美, 武田 大介, 筧 康正, 木本 明, 明石 昌也

  (公社)日本顎顔面インプラント学会, Nov. 2022, Japanese Journal of Maxillo Facial Implants, 21(3) (3), 237 - 237, Japanese


• The Impact of Pretreatment Low Body Mass Index on Cause-Specific Mortality in Patients with Squamous Cell Carcinoma of the Oral Cavity.

  Kyoko Kurioka, Shin Rin, Mitsunobu Otsuru, Tomohumi Naruse, Takumi Hasegawa, Nobuhiro Yamakawa, Shin-Ichi Yamada, Eiji Hirai, Kozo Yamamoto, Michihiro Ueda, Tadaaki Kirita, Masaya Akashi, Hiroshi Kurita, Yoichi Ohiro, Masaya Okura

  The association between the pretreatment body mass index (BMI) and oral squamous cell carcinoma (SCC) outcomes is controversial. We aimed to examine the association between BMI and cause-specific mortality due to cancer of the oral cavity and patterns of failure that correlate with increased mortality. We enrolled 2,023 East Asian patients in this multicenter cohort study. We used the cumulative incidence competing risks method and the Fine-Gray model to analyze factors associated with cause-specific mortality, local recurrence, regional metastasis, and distant metastasis as first events. The median follow-up period was 62 mo. The 5-year cause-specific mortality for patients with underweight was 25.7%, which was significantly higher than that for patients with normal weight (12.7%, P < 0.0001). The multivariate model revealed that underweight was an independent risk factor for cause-specific mortality and regional metastasis (P < 0.05). Moreover, patients with underweight displayed a 51% and 55% increased risk of cause-specific mortality and regional metastasis, respectively, compared with their normal weight counterparts. Local recurrence was not associated with the BMI categories; however, the incidence of distant metastasis inversely decreased with BMI value. In summary, being underweight at diagnosis should be considered a high-risk mortality factor for oral SCC.

  Oct. 2022, Nutrition and cancer, 1 - 12, English, International magazine

  Scientific journal


• Prevalence of and risk factors for postoperative complications after lower third molar extraction: A multicenter prospective observational study in Japan.

  Shin-Ichi Yamada, Takumi Hasegawa, Nobuhiko Yoshimura, Yusuke Hakoyama, Tetsuya Nitta, Narihiro Hirahara, Hironori Miyamoto, Hitoshi Yoshimura, Nobuhiro Ueda, Yoshiko Yamamura, Hideki Okuyama, Atsushi Takizawa, Yoshitaka Nakanishi, Eiji Iwata, Daisuke Akita, Ryuichi Itoh, Kiriko Kubo, Seiji Kondo, Hironobu Hata, Yoshito Koyama, Youji Miyamoto, Hirokazu Nakahara, Masaya Akashi, Tadaaki Kirita, Yasuyuki Shibuya, Masahiro Umeda, Hiroshi Kurita

  Lower third molar extraction is the most common surgical treatment among routine dental and oral surgical procedures. while the surgical procedures for lower third molar extraction are well established, the difficulty of tooth extraction and the frequency of postoperative complications differ depending on the patient's background. To establish a management protocol for the lower third molars, the prevalence of and risk factors for postoperative complications after lower third molar extraction were investigated in a large number of Japanese patients in a multicenter prospective study. During 6 consecutive months in 2020, 1826 lower third molar extractions were performed at the 20 participating institutions. The medical records of the patients were reviewed, and relevant data were extracted. The prevalence of and risk factors for postoperative complications were analyzed. The prevalence of postoperative complications after lower third molar extraction was 10.0%. Multivariate analysis indicated that age (≤32 vs >32, odds ratio [OR]: 1.428, 95% confidence interval [95% CI]: 1.040-1.962, P < .05), the radiographic anatomical relationship between the tooth roots and mandibular canal (overlapping of the roots and canal vs no close anatomical relationship between the roots and the superior border of the canal, OR: 2.078, 95% CI: 1.333-3.238, P < .01; overlapping of the roots and canal vs roots impinging on the superior border of the canal, OR: 1.599, 95% CI: 1.050-2.435, P < .05), and impaction depth according to the Pell and Gregory classification (position C vs position A, OR: 3.7622, 95% CI: 2.079-6.310, P < .001; position C vs position B, OR: 2.574, 95% CI: 1.574-4.210, P < .001) are significant independent risk factors for postoperative complications after lower third molar extraction. These results suggested that higher age and a deeply impacted tooth might be significant independent risk factors for postoperative complications after lower third molar extraction.

  Aug. 2022, Medicine, 101(32) (32), e29989, English, International magazine

  Scientific journal


• Actinomycosis of the Lower Lip: Report of a Case

  Manabu Shigeoka, Daisuke Takeda, Masaya Akashi

  Aug. 2022, CASE REPORTS IN DENTISTRY, 2022, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Treatment and Prognosis of Oral Cancer Patients with Confirmed Contralateral Neck Metastasis: A Multicenter Retrospective Analysis.

  Yuki Sakamoto, Mitsunobu Otsuru, Takumi Hasegawa, Masaya Akashi, Shin-Ichi Yamada, Hiroshi Kurita, Masaya Okura, Nobuhiro Yamakawa, Tadaaki Kirita, Souichi Yanamoto, Masahiro Umeda, Yuka Kojima

  The prognosis of oral cancer that has metastasized to the contralateral cervical lymph nodes is poor, although the appropriate treatment method has not been established because of its rarity. A multicenter retrospective study on the treatment and prognosis of pN2c oral cancer patients was conducted. We investigated the treatment and prognosis of 62 pN2c patients out of 388 pN+ patients with oral squamous cell carcinomas. Statistical analysis was performed on the various factors with overall survival (OS) and disease specific survival (DSS). In multivariate cox regression analysis, advanced T stage was significantly correlated with poor OS (p = 0.011) and DSS (p = 0.023) of patients with pN2c neck. In pN2c patients, OS, DSS, and neck control was not different between those undergoing ipsilateral neck dissection initially and those undergoing bilateral neck dissection. Thus, contralateral elective neck dissection is not recommended. The most important risk factor for prognosis in pN2c oral cancer patients is advanced T stage. No evidence was found to recommend contralateral elective neck dissection in clinically N1/2b patients. Therefore, the indication for contralateral elective neck dissection in N1/2b patients should be carefully determined in consideration of individual conditions.

  Jul. 2022, International journal of environmental research and public health, 19(15) (15), English, International magazine

  Scientific journal


• Exploratory clinical trial to evaluate the efficacy and safety of carbon dioxide paste in healthy people.

  Nanae Yatagai, Takumi Hasegawa, Katsusuke Kyotani, Tomohiro Noda, Rika Amano, Izumi Saito, Satomi Arimoto, Daisuke Takeda, Yasumasa Kakei, Masaya Akashi

  INTRODUCTION: Scarring and pain are postoperative complications in patients after head and neck cancer treatment; however, there is no effective treatment. These complications are affected by local blood flow disorders, and it is well known that the transcutaneous application of carbon dioxide (CO2) improves local blood flow. Previously, we have shown that the transcutaneous application of carbon dioxide causes absorption of CO2 and increase the oxygen (O2) pressure in the treated tissue; it is expected that the application of CO2 may reduce scarring and pain caused by cancer treatment. We newly introduced the CO2 paste as a new CO2 application method, which does not need to use CO2 gas directly. In this study, we aimed to apply of CO2 paste to healthy people and to investigate its usefulness, safety and feasibility by analysing the increase in blood flow and frequency of adverse events. METHODS: We applied carbon dioxide paste to skin over the sternocleidomastoid and gastrocnemius muscles of eight healthy volunteers. The changes in blood flow before and after the CO2 paste application using dynamic MRI, and changes in the vital signs were evaluated. RESULTS: In the neck area and middle layer of the lower leg, the signal intensity (SI) significantly increased 60 seconds after application. In the surface layer of the lower leg, the SI was significantly increased 60 and 300 seconds after paste application. Although mild heat was noted after the paste application, no obvious adverse events occurred. CONCLUSION: We demonstrated the increase in SI by dynamic MRI at the site of the carbon dioxide paste application, which indicates the paste application is effective in improving the blood flow.

  Jul. 2022, Medicine, 101(29) (29), e29511, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Cover Image

  Junya Kusumoto, Kazunobu Hashikawa, Akiko Sakakibara, Nobuyuki Murai, Masaya Akashi

  Wiley, Jul. 2022, Microsurgery, 42(5) (5)

  Scientific journal


• 当科における下顎骨びまん性硬化性骨髄炎症例に関する臨床的検討

  早瀬 悠夏, 楠元 順哉, 古土井 春吾, 武田 大介, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2022, 日本口腔科学会雑誌, 71(2) (2), 81 - 81, Japanese


• 放射線性顎骨壊死患者を対象とした予後とリスク因子に関する後ろ向き観察研究

  田所 慶誠, 長谷川 巧実, 佐藤 匠, 平岡 佑二郎, 有本 智美, 武田 大介, 楠元 順哉, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2022, 日本口腔科学会雑誌, 71(2) (2), 137 - 137, Japanese


• 緩和照射に関する臨床的検討

  松添 雄大, 南川 勉, 瓜生 開人, 棚倉 万紀子, 筧 康正, 長谷川 巧実, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2022, 日本口腔科学会雑誌, 71(2) (2), 91 - 91, Japanese


• 局所的炭酸ガス投与による口腔扁平上皮癌の腫瘍免疫抑制に対する改善効果

  八谷 奈苗, 長谷川 巧実, 武田 大介, 筧 康正, 榊原 晶子, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2022, 日本口腔科学会雑誌, 71(2) (2), 110 - 110, Japanese


• Evaluation of the Effects of Covering With Polyglycolic Acid Sheet on Wound Healing: A Pilot Histopathological Study.

  Yasumasa Kakei, Kazunobu Hashikawa, Kaito Uryu, Ryuichiro Funahara, Manabu Shigeoka, Masaya Akashi

  PURPOSE: Although the usefulness of polyglycolic acid (PGA) sheet for wound dressing has been recently reported, its histopathological effect on wound healing is not completely elucidated. This pilot study focused on the neo-epithelium formation and the remaining inflammation. METHODS: Full-thickness defects of 8 mm were created on the back of seven-week-old rats. Four rats were divided into the control (raw surface) group and the PGA group, in which the wounds were covered with a PGA sheet. The wounds were assessed on days seven and 12 after wound creation. The length of neo-epithelium on day seven was measured by referring to Masson's trichrome (MT) and α-smooth muscle actin (α-SMA) staining. The remaining inflammation on days seven and 12 was assessed with ionized calcium-binding adapter molecule 1 (Iba-1) staining. RESULTS: The average values of neo-epithelium length on day seven measured by referring to the borderline between MT staining and α-SMA expression were 959.2 μm in the control group and 582.2 μm in the PGA group. The number of Iba-1-positive cells on day 12 was significantly higher in the PGA group than in the control group. CONCLUSIONS: To assess the neo-epithelium length and the remaining inflammation, the α-SMA, MT, and Iba-1 staining may be appropriate.

  Jul. 2022, Cureus, 14(7) (7), e27209, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effect of compression on mandibular fracture haematoma-derived cells.

  Satomi Arimoto, Takumi Hasegawa, Eiji Iwata, Daisuke Takeda, Masaya Akashi

  Mechanical stress induces a variety of biochemical and morphological reactions in bone cell biology. This study aimed to investigate appropriate pressures of osteogenesis on the biological responses of 3-dimensional cultured human mandibular fracture haematoma-derived cells by compressive loading. Six patients with mandibular fractures who underwent open reduction and internal fixation were included in the study. During the operation, fracture haematomas that formed fibrin clots were manually removed before irrigation. First, pressures were applied to human mandibular fracture haematoma-derived cell-seeded collagen sponges. The sponges were subjected to mechanical compression using loading equipment applied at no compression, 0.5, or 1 mm. Compressive loading was applied to the samples prior to compression for 0, 6, 12, or 24 hours. Collagen sponge samples were collected for quantification of mRNA using several parameters including alkaline phosphatase (ALP), osteopontin (OPN), osterix (OSX), runt-related gene 2 (RUNX2), protein level, and immunocytochemistry (anti-sclerostin). Among these the 0.5 mm compression group compared with the control and 1.0 mm compression groups upregulated mRNA expression of OPN and OSX after 24 hours. Additionally, compared with the control group, a significantly higher OSX gene expression was observed in both the 0.5 mm and 1.0 mm groups after 6, 12, and 24 hours of compression (p < 0.05). However, no significant differences were observed regarding ALP and RUNX2 expression. These results indicated increased stimulation of osteogenesis of the mandibular fracture-line gap in the 0.5 mm compression group compared with the control and 1.0 mm compression groups.

  Jun. 2022, The British journal of oral & maxillofacial surgery, 60(9) (9), 1216 - 1223, English, International magazine

  Scientific journal


• 放射線性下顎骨壊死の低体重患者に下顎骨区域切除を行った1例

  早瀬 悠夏, 楠元 順哉, 薄田 友理子, 佐藤 匠, 印南 勇祐, 明石 昌也

  (一社)日本口腔感染症学会, Jun. 2022, 日本口腔感染症学会雑誌, 29(1) (1), 34 - 35, Japanese


• Factors Associated with Treatment Outcomes and Pathological Features in Patients with Osteoradionecrosis: A Retrospective Study

  Yoshiaki Tadokoro, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Eiji Iwata, Izumi Saito, Junya Kusumoto, Masaya Akashi

  Jun. 2022, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 19(11) (11), English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Blowing time ratio and high-resolution manometry to evaluate swallowing function of patients with oral and oropharyngeal cancer.

  Hirokazu Komatsu, Tatsuya Furukawa, Keisuke Iritani, Shun Tatehara, Miki Takahashi, Shinobu Iwaki, Yasumasa Kakei, Takumi Hasegawa, Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Kazunobu Hashikawa, Naomi Kiyota, Ryohei Sasaki, Masaya Akashi, Ken-Ichi Nibu

  OBJECTIVE: The blowing time ratio, which is the ratio of the blowing time when the nostrils are open and closed, is significantly correlated with velopharyngeal pressure, not only during speech but also during swallowing. This study aimed to further evaluate the usefulness of the blowing time ratio as a screening tool to evaluate the swallowing pressure of patients treated for oral and oropharyngeal cancers using high-resolution manometery (HRM). METHODS: Ten patients treated for oral or oropharyngeal cancer were recruited for this study. Swallowing pressures at the velopharynx, oropharynx, and upper esophageal sphincter (UES) were measured using HRM. Their correlations with the blowing time ratio were analyzed. RESULTS: The blowing time ratio was significantly correlated with the swallowing pressures of the oropharynx (CC = 0.815, p = 0.004) and the velopharynx (CC = 0.657, p = 0.039), but not of the UES. CONCLUSIONS: The present results further support our previous finding that the blowing time ratio is a useful screening tool to evaluate velopharyngeal and oropharyngeal swallowing pressures in patients treated for oral and oropharyngeal cancer.

  Jun. 2022, Auris, nasus, larynx, 49(3) (3), 477 - 483, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Factors Associated with Treatment Outcomes and Pathological Features in Patients with Osteoradionecrosis: A Retrospective Study.

  Yoshiaki Tadokoro, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Eiji Iwata, Izumi Saito, Junya Kusumoto, Masaya Akashi

  A standard treatment for osteoradionecrosis (ORN) has not yet been established because of the diversity. Therefore, identifying the risk factors for a poor prognosis is essential. This study retrospectively investigated the factors associated with the prognosis of ORN in 68 patients. Relevant clinical data of all patients were obtained. Of the patients, 16 who underwent extensive surgery underwent histopathological analysis. The necrotic changes of the anterior and posterior margins in the cortical and cancellous bones were investigated. Multivariate analyses showed statistically significant associations between poor prognosis in patients with ORN and high radiation dose (hazard ratio [HR] 1.15), orocutaneous fistula (HR 2.93), and absence of sequestration (HR 2.49). Histopathological analysis showed a viable anterior margin of the middle portion of the cortical bone for all recovered cases; in contrast, most cases (75%) with a poor prognosis showed necrotic changes. The anterior margin of the cancellous bone was viable and resilient to high irradiation, regardless of the prognosis. These results suggest that patients with orocutaneous fistula should receive early surgical intervention, even if the affected area is limited or asymptomatic. In extensive surgery, a sufficient safety margin of necrotic bone, particularly in the anterior region, is required to improve the prognosis.

  May 2022, International journal of environmental research and public health, 19(11) (11), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Efficacy of Ibuprofen Gargle for Postoperative Pain After Mandibular Third Molar Extraction: Protocol for a Phase II, Placebo-Controlled, Double-Blind, Randomized Crossover Trial.

  Yasumasa Kakei, Takeshi Ioroi, Takahiro Ito, Yutaro Okazaki, Takumi Hasegawa, Ikuko Yano, Masaya Akashi

  BACKGROUND: Extraction of mandibular third molars is one of the most commonly performed oral surgical procedures, and nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management. Oral NSAIDs are associated with adverse events such as gastrointestinal disorders, renal and hepatic dysfunction, and platelet dysfunction. Topical analgesics have been proposed as alternatives to oral and injectable medications to safely improve postoperative pain relief. We will conduct a single-center, placebo-controlled, double-blind, randomized crossover trial to assess the pain-relieving effect of an ibuprofen-containing gargle in patients undergoing extraction of mandibular third molars when compared with a placebo gargle. OBJECTIVE: This will be the first clinical study to compare the efficacy of an ibuprofen gargle with that of a placebo for relieving postoperative pain in addition to loxoprofen after mandibular third molar extraction. METHODS: This study will be performed at Kobe University Hospital. Participants (N=40) will be randomized equally to 1 of 2 groups. The ibuprofen-placebo group will receive an ibuprofen gargle on postoperative day (POD) 1 and a placebo gargle on POD 2. The placebo-ibuprofen group will receive a placebo gargle on POD 1 and an ibuprofen gargle on POD 2. Both groups will receive ibuprofen gargles on PODs 3-5 at least once daily. The primary objective is to estimate the within-subject difference on a visual analog scale (VAS) before and 5 minutes after using the ibuprofen or placebo gargle on PODs 1 and 2. The secondary objectives are to estimate the within-subject differences in ΔVAS before and 15 minutes after using the ibuprofen or placebo gargle on PODs 1 and 2, ΔVAS before and 5 or 15 minutes after using the ibuprofen gargle on PODs 3-5, overall efficacy (self-completion, 5 scales) on PODs 1-5, daily frequency of use (ibuprofen or placebo gargle and analgesics) on PODs 1-7, and the occurrence of adverse events. RESULTS: The Certified Review Board of Kobe University approved the study. The intervention was implemented in May 2021. For the primary analysis, we will calculate the mean and SD of ΔVAS5 on PODs 1 and 2 and the within-study difference in ΔVAS5. The treatment effect will be estimated by dividing the mean ΔVAS5 in the within-subject difference by 2 and calculating the P value using an unpaired t test. For the secondary analysis, we will calculate the mean and SD of ΔVAS15 on PODs 1 and 2 and the within-study difference in ΔVAS15. The treatment effect will be estimated as in the primary analysis. CONCLUSIONS: This trial will provide exploratory evidence of the efficacy and safety of an ibuprofen gargle for pain reduction after mandibular third molar extraction. TRIAL REGISTRATION: Japan Registry of Clinical Trials jRCTs051210022; https://tinyurl.com/39ej23zu. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/35533.

  May 2022, JMIR research protocols, 11(5) (5), e35533, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Significance of intratumoural CD163+ macrophages in oral malignant melanoma: A preliminary study.

  Takayuki Kodama, Manabu Shigeoka, Mari Nishio, Yu-Ichiro Koma, Masaya Akashi, Hiroshi Yokozaki

  May 2022, Oral diseases, English, International magazine

  Scientific journal


• Perioperative oral care can prevent surgical site infection after colorectal cancer surgery: A multicenter, retrospective study of 1,926 cases analyzed by propensity score matching.

  Hiroshi Nobuhara, Yasuhiro Matsugu, Sakiko Soutome, Saki Hayashida, Takumi Hasegawa, Masaya Akashi, Shin-Ichi Yamada, Hiroshi Kurita, Hirokazu Nakahara, Miyuka Nakahara, Nobuhiro Ueda, Tadaaki Kirita, Tomohisa Nakamura, Yasuyuki Shibuya, Kazuyo Mori, Taihei Yamaguchi

  BACKGROUND: Surgical site infection is a common postoperative complication of colorectal cancer surgery, and surgical site infection increases medical costs, prolongs hospitalization, and worsens long-term prognosis. Perioperative oral care has been reported to be effective in preventing postoperative pneumonia, although there are only a few reports on its effectiveness in preventing surgical site infection. This study aimed to determine the role of perioperative oral care in surgical site infection prevention after colorectal cancer surgery. METHODS: In this study, 1,926 patients with colorectal cancer from 8 institutions were enrolled; 808 patients (oral care group) received perioperative oral care at the hospital's dental clinic, and 1,118 (control group) did not receive perioperative oral care. The data were matched by propensity score to reduce bias. Ultimately, a total of 1,480 patients were included in the analysis. RESULTS: The incidence of surgical site infection was significantly lower in the oral care group than in the control group (8.4% vs 15.7%, P < .001). Multivariate logistic regression analysis revealed 4 independent risk factors for surgical site infection: low albumin level, rectal cancer, blood loss, and lack of perioperative oral care. Lack of perioperative oral care had an odds ratio of 2.100 (95% confidence interval 1.510-2.930, P < .001). CONCLUSION: These results suggest that perioperative oral care can reduce the incidence of surgical site infection after colorectal cancer resection. Perioperative oral care may have an important role in the future perioperative management of colorectal cancer as a safe and effective method of surgical site infection prevention, although further validation in prospective studies is needed.

  Apr. 2022, Surgery, 172(2) (2), 530 - 536, English, International magazine

  Scientific journal


• 口腔粘膜炎に対するエピシル口腔溶液の効果や有効性について

  岡崎 葉菜, 武田 大介, 西井 美佳, 村川 智美, 片山 めぐみ, 澤田 麻衣子, 楠元 順哉, 明石 昌也

  (一社)日本口腔ケア学会, Apr. 2022, 日本口腔ケア学会雑誌, 16(3) (3), 140 - 140, Japanese


• 頭頸部がん放射線療法における口腔カンジダ症に対するミコナゾール貼付薬の有効性について

  西井 美佳, 楠元 順哉, 村川 智美, 岡崎 葉菜, 片山 めぐみ, 澤田 麻衣子, 武田 大介, 明石 昌也

  (一社)日本口腔ケア学会, Apr. 2022, 日本口腔ケア学会雑誌, 16(3) (3), 141 - 141, Japanese


• Strategy for preventing skin paddle necrosis in mandibular reconstruction with free fibula osteocutaneous flap.

  Junya Kusumoto, Kazunobu Hashikawa, Akiko Sakakibara, Nobuyuki Murai, Masaya Akashi

  BACKGROUND: Non-thrombotic skin paddle necrosis occasionally occurs during mandibular reconstructions with free fibula osteocutaneous flaps. The number of perforators, size of the skin paddle, and ischemia time of the flap are considered as causes of skin paddle necrosis. The importance of donor side selection has also been highlighted. This study aimed to investigate the leading cause of skin paddle necrosis and the optimal reconstructive procedure. METHODS: A total of 66 patients who underwent mandibular reconstruction using a free fibula osteocutaneous flap were retrospectively analyzed. Skin paddle necrosis, number of cutaneous perforators, size of the skin paddle, and ischemia time of the flap were investigated. An incorrect "laterality" was defined as a skin paddle (septum) covering the reconstruction plate. Donor-site morbidity was recorded. RESULTS: Skin paddle necrosis occurred in 15.2% of patients. An incorrect laterality was associated with a higher incidence of skin paddle necrosis (odds ratio, 22.0; 95% confidence interval, 2.5-195; p = .005). Donor-site morbidity was noted in 18.8% of the patients, without any significant difference in terms of the donor side with and without skin graft (p = .592). The postoperative activities of daily living were not affected. CONCLUSIONS: To prevent skin paddle necrosis, donor side selection is an important safety strategy during mandibular reconstruction with free fibula osteocutaneous flap. The postoperative activities of daily living were found to be little affected by differences in the donor side.

  Mar. 2022, Microsurgery, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Success of dental implants in patients with large bone defect and analysis of risk factors for implant failure: a non-randomized retrospective cohort study.

  Takumi Hasegawa, Aki Sasaki, Izumi Saito, Satomi Arimoto, Nanae Yatagai, Yujiro Hiraoka, Daisuke Takeda, Yasumasa Kakei, Masaya Akashi

  OBJECTIVES: This study aimed to retrospectively investigate the success and survival rates of dental implants used for dentomaxillary prostheses at our hospital and the risk factors associated with large bone defects. MATERIALS AND METHODS: A total of 138 external joint system implants used for dentomaxillary prostheses in 40 patients with large bone defects were included in this study. The alveolar bone at the site of implant insertion was evaluated using panoramic radiography and computed tomography. Various risk factors (demographic characteristics, dental status, and operative factors such as the employment of alveolar bone augmentation, the site, the length, and diameter of implants) for implant failure and complete implant loss were investigated using univariate and multivariate analyses. The associations between the variables and the success and survival rates of dental implants were analyzed using the multivariate Cox proportional hazard models. RESULTS: The 10-year overall success and survival rates were 81.3% and 88.4% in this study. Multivariable analysis showed that the male sex (HR 6.22), shorter implants (≤ 8.5 mm) (HR 5.21), and bone augmentation (HR 2.58) were independent predictors of success rate. Bone augmentation (HR 5.14) and narrow implants (≤ 3.3 mm) (HR 3.86) were independent predictors of the survival rate. CONCLUSION: Male sex, shorter or narrow implants, and bone augmentation were independent risk factors for dental implants used in dentomaxillary prostheses in patients with large bone defects. CLINICAL RELEVANCE: Clinicians should consider these risk factors and pay close attention to the management of these patients.

  Mar. 2022, Clinical oral investigations, 26(3) (3), 2743 - 2750, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Risk factors associated with post-extraction bleeding in patients on warfarin or direct-acting oral anticoagulants: a retrospective cohort study.

  Eiji Iwata, Akira Tachibana, Junya Kusumoto, Takumi Hasegawa, Ryo Kadoya, Yui Enomoto, Naoki Takata, Masaya Akashi

  PURPOSE: The purpose of this study was to investigate the risk factors associated with post-extraction persistent bleeding in patients on warfarin or direct-acting oral anticoagulants (DOACs) and the ability of risk scores to predict post-extraction bleeding. METHODS: Three hundred ninety-one patients taking warfarin or DOACs underwent tooth extractions. Various risk factors for post-extraction bleeding, including number of tooth extraction, with antiplatelet therapy, and risk scores, were investigated by univariate and multivariate analyses. A post-extraction bleeding was classified into grades 1-3. RESULTS: The incidence of post-extraction bleeding was 26.8% (77 out of 287 patients; grade 1: 63, grade 2:14) in patients taking warfarin, and 26.0% (27 out of 104 patients; grade 1: 20, grade 2:7) in patients taking warfarin DOACs. Multivariate analyses showed that multiple teeth extractions and HAS-BLED scores (above 3 points) in patients taking warfarin, and only multiple teeth extractions in patients taking DOAC, were significantly associated with post-extraction bleeding, respectively. CONCLUSION: Most of the post-extraction bleedings were grade 1, which can be stopped by eligibly pressing gauze by surgeons. If patients taking anticoagulants are scheduled to undergo multiple teeth extractions or their HAS-BLED score are above 3 points (if warfarin), we recommend informing patients risk of post-extraction bleeding before operation, taking carefully hemostasis, and instructing patients to bite down accurately on the gauze for longer than usual.

  Jan. 2022, Oral and maxillofacial surgery, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Actinomycosis of the Lower Lip: Report of a Case.

  Manabu Shigeoka, Daisuke Takeda, Masaya Akashi

  Actinomycosis is usually a chronic infectious disease caused by Actinomyces species, which are anaerobic Gram-positive bacteria that normally colonize the human oral cavity and digestive and urogenital tracts. Although this lesion often occurs on soft tissue around the mandible, cases localized in the lip are very uncommon. We encountered a patient with actinomycosis in the lower lip. A 76-year-old woman with a 5-mm submucosal nodule of the lower lip was referred to our hospital from a dental clinic. The clinical diagnosis was a benign submucosal tumor. Total excision and histological examination were conducted. No oral antibiotic therapy was prescribed. The histological diagnosis was actinomycosis. The postoperative course was uneventful with no signs of recurrence during the 6 months after surgery.

  2022, Case reports in dentistry, 2022, 6121315 - 6121315, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• A Case of a Rare Branching Pattern in the Carotid Artery.

  Ayumi Sakai, Kazunobu Hashikawa, Akiko Sakakibara, Nobuyuki Murai, Tadashi Nomura, Masaya Akashi, Hiroto Terashi

  2022, Eplasty, 22, ic1, English, International magazine


• アカデミア臨床研究環境のこれまで 臨床研究法施行の背景

  筧 康正, 永井 洋士, 長谷川 巧実, 明石 昌也

  (一社)日本口腔腫瘍学会, Dec. 2021, 日本口腔腫瘍学会誌, 33(4) (4), 159 - 163, Japanese


• アカデミア臨床研究環境のこれまで 臨床研究法施行の背景

  筧 康正, 永井 洋士, 長谷川 巧実, 明石 昌也

  (一社)日本口腔腫瘍学会, Dec. 2021, 日本口腔腫瘍学会誌, 33(4) (4), 159 - 163, Japanese


• 口腔癌術後の再建組織より採取した分層植皮により顎堤形成術を施行した1例

  重永 一輝, 有本 智美, 武田 大介, 木本 明, 長谷川 巧実, 明石 昌也

  (公社)日本顎顔面インプラント学会, Nov. 2021, Japanese Journal of Maxillo Facial Implants, 20(3) (3), 189 - 189, Japanese


• 放射線下顎骨壊死に対する腓骨皮弁再建後にインプラントによる咬合回復を行った1例

  武田 大介, 有本 智美, 長谷川 巧実, 明石 昌也

  (公社)日本顎顔面インプラント学会, Nov. 2021, Japanese Journal of Maxillo Facial Implants, 20(3) (3), 227 - 227, Japanese


• Local Application of Transcutaneous Carbon Dioxide Paste Decreases Inflammation and Accelerates Wound Healing.

  Rika Amano-Iga, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi

  INTRODUCTION:  Delayed wound healing after surgery lowers the long-term quality of a patient's life and leads to discomfort and pain. However, treatments for wound healing are often difficult and have not yet been fully established. In this study, we investigated the effect of a special paste that can be administered transdermally and holds a non-gaseous carbon dioxide (CO2) source in its carrier, which can be applied to the head and neck region for wound healing in a rat skin defect model. METHODS: Forty-eight Sprague Dawley rats were randomized into control and CO2 groups. We punched a 6.2-mm wound on the back of each rat. The control rats were left untreated, whereas rats in the CO2 group were treated with the CO2 paste every day after surgery. We evaluated wound healing 3, 7, 14, and 21 days after wounding by analyzing the diameter of the wound, gene expression of inflammatory markers vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β, hypoxia-inducible factor (HIF)-1α, interleukin (IL)-1β, and IL-6 using quantitative real-time polymerase chain reaction, hematoxylin and eosin, and immunohistochemical staining patterns. RESULTS: Rats in the CO2 group showed accelerated wound healing compared to those in the control group. Furthermore, VEGF and TGF-β were overexpressed, whereas HIF-1α, IL-1β, and IL-6 were downregulated in the rats treated with CO2. Immunohistochemical analysis also revealed similar patterns of expression. CONCLUSION: Taken together, the CO2 paste promoted wound healing by regulating the hypoxic environment, reducing inflammation, and accelerating angiogenesis.

  Nov. 2021, Cureus, 13(11) (11), e19518, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Risk factors for severe radiation-induced oral mucositis in patients with oral cancer

  Sakiko Soutome, Souichi Yanamoto, Mika Nishii, Yuka Kojima, Takumi Hasegawa, Madoka Funahara, Masaya Akashi, Toshiyuki Saito, Masahiro Umeda

  Oct. 2021, Journal of Dental Sciences, 16(4) (4), 1241 - 1246

  Scientific journal


• Sturge-Weber症候群に伴う口腔内化膿性肉芽腫の治療経験:術前塞栓療法と外科的切除の併用

  酒井 亜結美, 野村 正, 明石 昌也, 橋川 和信, 寺師 浩人

  (一社)日本形成外科学会, Sep. 2021, 日本形成外科学会会誌, 41(9) (9), 522 - 527, Japanese


• Peripheral facial nerve schwannoma at the inferior mandibular margin: a case report.

  Akiko Sakakibara, Takumi Hasegawa, Daisuke Takeda, Junya Kusumoto, Shunsuke Sakakibara, Masaya Akashi

  Schwannomas commonly occur in the head and neck region as acoustic neuromas. Facial nerve schwannomas are rare and usually occur in the temporal region. A 57-year-old woman presented with a mass at the right mandibular margin. Magnetic resonance imaging revealed a schwannoma located immediately caudal to the mental foramen. We were initially uncertain whether it arose from the trigeminal nerve or the facial nerve. Excision was performed under general anesthesia. The mass was encapsulated and easily detached from the surrounding tissue. The nerve of origin was identified proximal to the tumor. A facial nerve origin was confirmed as the muscles supplied by the marginal mandibular branch of the facial nerve moved on nerve stimulation. Nerve fibers were not found distal to the tumor, possibly because they had been cut during excision. We believe that this is the first report of a schwannoma arising from the peripheral facial nerve.

  Jul. 2021, Journal of surgical case reports, 2021(7) (7), rjab299, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 皮膚充填材への感染により生じた頬部蜂窩織炎の1例

  榎本 由依, 橘 進彰, 格谷 僚, 岩田 英治, 高田 直樹, 明石 昌也

  (公社)日本口腔外科学会, Jul. 2021, 日本口腔外科学会雑誌, 67(7) (7), 447 - 451, Japanese


• 皮膚充填材への感染により生じた頬部蜂窩織炎の1例

  榎本 由依, 橘 進彰, 格谷 僚, 岩田 英治, 高田 直樹, 明石 昌也

  (公社)日本口腔外科学会, Jul. 2021, 日本口腔外科学会雑誌, 67(7) (7), 447 - 451, Japanese


• Tongue Cancer Cell-Derived CCL20 Induced by Interaction With Macrophages Promotes CD163 Expression on Macrophages

  Manabu Shigeoka, Yu-ichiro Koma, Takayuki Kodama, Mari Nishio, Masaya Akashi, Hiroshi Yokozaki

  CD163-positive macrophages contribute to the aggressiveness of oral squamous cell carcinoma. We showed in a previous report that CD163-positive macrophages infiltrated not only to the cancer nest but also to its surrounding epithelium, depending on the presence of stromal invasion in tongue carcinogenesis. However, the role of intraepithelial macrophages in tongue carcinogenesis remains unclear. In this study, we assessed the biological behavior of intraepithelial macrophages on their interaction with cancer cells. We established the indirect coculture system (intraepithelial neoplasia model) and direct coculture system (invasive cancer model) of human monocytic leukemia cell line THP-1-derived CD163-positive macrophages with SCC25, a tongue squamous cell carcinoma (TSCC) cell line. Conditioned media (CM) harvested from these systems were analyzed using cytokine array and enzyme-linked immunosorbent assay and extracted a specific upregulated cytokine in CM from the direct coculture system (direct CM). The correlation of both this cytokine and its receptor with various clinicopathological factors were evaluated based on immunohistochemistry using clinical samples from 59 patients with TSCC. Moreover, the effect of this cytokine in direct CM on the phenotypic alterations of THP-1 was confirmed by real-time polymerase chain reaction, western blotting, immunofluorescence, and transwell migration assay. It was shown that CCL20 was induced in the direct CM specifically. Interestingly, CCL20 was produced primarily in SCC25. The expression level of CCR6, which is a sole receptor of CCL20, was higher than the expression level of SCC25. Our immunohistochemical investigation showed that CCL20 and CCR6 expression was associated with lymphatic vessel invasion and the number of CD163-positive macrophages. Recombinant human CCL20 induced the CD163 expression and promoted migration of THP-1. We also confirmed that a neutralizing anti-CCL20 antibody blocked the induction of CD163 expression by direct CM in THP-1. Moreover, ERK1/2 phosphorylation was associated with the CCL20-driven induction of CD163 expression in THP-1. Tongue cancer cell-derived CCL20 that was induced by interaction with macrophages promotes CD163 expression on macrophages.

  Frontiers Media SA, Jun. 2021, Frontiers in Oncology, 11

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Case Report of Tongue Lymphoepithelial Carcinoma with a Histological Diagnostic Dilemma.

  Daisuke Takeda, Manabu Shigeoka, Tenyu Sugano, Nanae Yatagai, Takumi Hasegawa, Masaya Akashi

  Most head and neck lymphoepithelial carcinomas (LECs) arise in the nasopharynx and harbor Epstein-Barr virus (EBV). LEC is also a rare subtype of the oral squamous cell carcinoma (SCC). Morphologically, LEC is defined as resembling non-keratinizing nasopharyngeal carcinoma, undifferentiated subtype. The histological features and pathogenesis of oral LEC are not established. We describe a case of tongue LEC with histopathological diagnostic difficulties. A 72-year-old Japanese female presented with a whitish change on her left-side tongue. The diagnosis was atypical epithelium; neoplastic change could not be ruled out by a biopsy. Although the lesion was monitored at our hospital per her request, invasive carcinoma was detected 11 months later. Microscopically, conventional SCC was observed with the characteristic features as LEC confined to the deep part of the lesion. We briefly discuss this unusual histological finding and make a novel proposal for distinguishing oral LEC from LECs in other regions based on these histological findings.

  Jun. 2021, Diagnostics (Basel, Switzerland), 11(6) (6), English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• A Case Report of Tongue Lymphoepithelial Carcinoma with a Histological Diagnostic Dilemma

  Daisuke Takeda, Manabu Shigeoka, Tenyu Sugano, Nanae Yatagai, Takumi Hasegawa, Masaya Akashi

  Jun. 2021, DIAGNOSTICS, 11(6) (6), English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Denosumab-related osteonecrosis of the jaw after tooth extraction and the effects of a short drug holiday in cancer patients: a multicenter retrospective study.

  T Hasegawa, N Ueda, S I Yamada, S Kato, E Iwata, S Hayashida, Y Kojima, M Shinohara, I Tojo, H Nakahara, T Yamaguchi, T Kirita, H Kurita, Y Shibuya, S Soutome, M Akashi

  Pre-existing inflammation, corticosteroid therapy, periapical periodontitis, longer duration of denosumab therapy, and female sex were significantly associated with an increased risk of denosumab-related osteonecrosis of the jaw after tooth extraction in patients with cancer on oncologic doses of denosumab. A short drug holiday did not protect against this complication. INTRODUCTION: This study retrospectively investigated the relationship between various risk factors, including brief discontinuation of denosumab, and development of denosumab-related osteonecrosis of the jaw (DRONJ) after tooth extraction in patients with cancer who were receiving oncologic doses of this agent. METHODS: Data were collected on demographic characteristics, duration of denosumab therapy, whether or not denosumab was discontinued before tooth extraction (drug holiday), duration of discontinuation, presence of pre-existing inflammation, and whether or not additional surgical procedures were performed. Risk factors for DRONJ after tooth extraction were evaluated by univariate and multivariate analyses. RESULTS: A total of 136 dental extractions were performed in 72 patients (31 men, 41 women) with cancer who were receiving oncologic doses of denosumab. Post-extraction DRONJ was diagnosed in 39 teeth (28.7%) in 25 patients. Tooth extraction was significantly associated with development of DRONJ only in patients with pre-existing inflammation (odds ratio [OR] 243.77), those on corticosteroid therapy (OR 73.50), those with periapical periodontitis (OR 14.13), those who had been taking oncologic doses of denosumab for a longer period (OR 4.69), and in women (OR 1.04). There was no significant difference in the occurrence of DRONJ between patients who had a drug holiday before tooth extraction and those who did not. CONCLUSIONS: These findings suggest that inflamed teeth should be extracted immediately in patients with cancer who are receiving oncologic doses of denosumab. Drug holidays have no significant impact on the risk of DRONJ.

  May 2021, Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Alteration of Macrophage Infiltrating Compartment: A Novel View on Oral Carcinogenesis

  Manabu Shigeoka, Yu-ichiro Koma, Mari Nishio, Masaya Akashi, Hiroshi Yokozaki

  <b><i>Background:</i></b> The mortality of oral squamous cell carcinoma (OSCC) has remained high for decades; therefore, methods for early detection of OSCC are warranted. However, in the oral cavity, various mucosal diseases may be encountered, including reactive lesions and oral potentially malignant disorders, and it is difficult to differentiate OSCC from these lesions based on both clinical and histopathological findings. It is well known that chronic inflammation contributes to oral cancer development. Macrophages are among the most common inflammatory cells in cancer stromal tissue and have various roles in cancer aggressiveness. Although the roles of macrophages in cancer development have attracted attention, only a few studies have linked macrophages to carcinogenesis, particularly, oral precancerous lesions. <b><i>Summary:</i></b> This review article consists of 3 parts: first, we summarize current knowledge on macrophages in human various epithelial precancerous lesions, excluding the oral cavity, to show the importance and gaps in knowledge regarding macrophages in carcinogenesis; second, we review published data related to the role of macrophages in oral carcinogenesis; finally, we present a novel view on oral carcinogenesis, focusing on crosstalk between epithelial cells and macrophages. <b><i>Key Messages:</i></b> The biological features of macrophages in oral carcinogenesis differ drastically depending on the anatomical compartment that they infiltrate. Focusing on the alteration of macrophage infiltrating compartment may serve as a useful novel approach for studying the role of the macrophages in oral carcinogenesis and for gaining further insight into cancer prevention and early detection.

  S. Karger AG, May 2021, Pathobiology, 1 - 11

  Scientific journal


• 早期舌癌治療のパラダイムシフトへ向けて-医科歯科病理の知の融合- 早期舌扁平上皮癌における頸部後発転移の新たな予測因子

  山川 延宏, 桐田 忠昭, 梅田 正博, 柳本 惣一, 大鶴 光信, 大倉 正也, 相川 友直, 太田 嘉英, 栗田 浩, 山田 慎一, 明石 昌也, 長谷川 巧, 上田 倫弘

  (一社)日本頭頸部癌学会, May 2021, 頭頸部癌, 47(2) (2), 142 - 142, Japanese


• 口腔・中咽頭癌放射線治療326例における重症口腔粘膜炎および口腔カンジダ症発症に関連する因子

  西井 美佳, 五月女 さき子, 岩田 英治, 長谷川 巧実, 兒島 由佳, 船原 まどか, 梅田 正博, 明石 昌也

  (一社)日本口腔ケア学会, Apr. 2021, 日本口腔ケア学会雑誌, 15(3) (3), 145 - 145, Japanese


• Occurrence and Treatment Outcome of Late Complications After Free Fibula Flap Reconstruction for Mandibular Osteoradionecrosis.

  Junya Yamashita, Masaya Akashi, Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Kazunobu Hashikawa

  Corresponding, Mar. 2021, Cureus, 13(3) (3), e13833, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Impact of Oral Health Status on Postoperative Complications and Functional Recovery After Cardiovascular Surgery

  Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Yasunori Tsuboi, Kodai Komaki, Nagisa Nanba, Kazuhiro P. Izawa, Takeshi Inoue, Yoshitada Sakai, Masaya Akashi, Ken ichi Hirata, Kenji Okada

  Mar. 2021, CJC Open, 3(3) (3), 276 - 284

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Can CT predict the development of oroantral fistula in patients undergoing maxillary third molar removal?

  Eiji Iwata, Takumi Hasegawa, Masaki Kobayashi, Akira Tachibana, Naoki Takata, Toshiya Oko, Daisuke Takeda, Yoshiki Ishida, Tsuyoshi Fujita, Ikuko Goto, Junichiro Takeuchi, Masaya Akashi

  PURPOSE: In maxillary wisdom tooth extraction, the necessity of CT is unknown. The purpose of this study was to investigate whether CT adding to orthopantomography is useful for predicting oroantral perforation during maxillary third molar extraction. METHODS: Various risk factors for oroantral perforation during maxillary third molar extraction were investigated by univariate and multivariate analyses. We analyzed those of all patients and the patients who underwent CT, respectively. The proximity of the roots to the maxillary sinus floor (root-sinus [RS] classification) and Archer classification were assessed using panoramic radiography. The number of roots and vertical relationship were assessed using CT. RESULTS: A total of 604 out of 3299 patients underwent CT adding to orthopantomography. In all cases, multivariate analyses except for CT findings showed that the RS classification type III/IV and the Archer classification Type B/C/D in panoramic findings were significantly correlated with oroantral perforation as radiological findings. In cases for which CT was performed, multivariate analyses showed that one root (OR 12.87) and the vertical relationship Type D (OR 5.63) in CT findings, besides the RS classification type III/IV (OR 4.47) in panoramic findings, were significantly related to oroantral perforation. CONCLUSION: The RS classification and the Archer classification in panoramic findings can predict the risk of oroantral perforation. The usefulness of CT adding to orthopantomography is limited. However, when the relationship between the upper wisdom tooth and maxillary sinus floor (RS classification) is unclear, to check whether the number of roots is one and the apex of one root is projecting into the maxillary sinus in CT findings, is useful for the prediction.

  Mar. 2021, Oral and maxillofacial surgery, 25(1) (1), 7 - 17, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Association between dental extraction after radiotherapy and osteoradionecrosis: A multi-centre retrospective study.

  Izumi Saito, Takumi Hasegawa, Yumiko Kawashita, Shinichiro Kato, Shin-Ichi Yamada, Yuka Kojima, Nobuhiro Ueda, Masahiro Umeda, Yasuyuki Shibuya, Hiroshi Kurita, Tadaaki Kirita, Masaya Akashi

  OBJECTIVE: Radiotherapy (RT) carries a substantial risk for the development of osteoradionecrosis (ORN) of the jaw. This study was performed to investigate the relationship between dental extractions after RT and the development of ORN. MATERIAL AND METHODS: Thirty-two patients with head and neck cancer who underwent tooth extraction after RT were investigated for correlations between the development of ORN and various factors. RESULTS: Postextraction ORN was diagnosed in 12 (12.1%) teeth of 9 patients. The RT dose against the site of tooth extraction was 62.0 and 37.4 Gy in the ORN and Non-ORN groups, respectively (p < .001). The duration from RT to tooth extraction was 41.2 and 28.2 months in the ORN and Non-ORN groups, respectively (p = .025). Tooth extraction was significantly associated with ORN in patients with a high RT dose against the site (odds ratio = 1.231) and a longer duration of time from RT (odds ratio = 1.084). CONCLUSIONS: Extraction of non-restorable teeth and those with a poor prognosis should not necessarily be postponed even when patients are undergoing RT. However, clinicians should pay special attention to postoperative management after tooth extraction in patients with a high RT dose and longer time from RT.

  Mar. 2021, Oral diseases, 28(4) (4), 1181 - 1187, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Time to Recurrence Associated With Poor Prognosis in Japanese Oral Squamous Cell Carcinoma Patients

  Takumi Hasegawa, Erina Kobayashi, Rika Amano, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akira Kimoto, Akiko Sakakibara, Masaya Akashi

  Feb. 2021, JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, 21(3) (3), 856 - 864, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Relationship between oral health and physical frailty in patients with cardiovascular disease.

  Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Yasunori Tsuboi, Kodai Komaki, Nagisa Nanba, Kazuhiro P Izawa, Yoshitada Sakai, Masaya Akashi, Ken-Ichi Hirata

  BACKGROUND: Oral health is important for maintaining general health and is associated with components of physical frailty among the elderly. Oral health problems are common in hospitalized patients; however, no reports on oral health problems pertain to patients with cardiovascular diseases (CVD). The present study aimed to evaluate the association between oral health and physical frailty in these patients. METHODS: In this retrospective cohort study, we included consecutive patients admitted for CVD to our hospital between May 2014 and December 2018. Physical frailty was assessed using the Short Physical Performance Battery (SPPB). Oral health characteristics, such as the number of remaining teeth, denture use, occlusal support, and periodontal status, were assessed. RESULTS: In our cohort (n = 457), 111 (24.3%) patients had physical frailty. Univariate linear regression showed that the number of teeth present and the prevalence of occlusal support were significantly lower in patients with than without physical frailty. Pearson correlation indicated that the number of teeth significantly correlated with the nutritional status (r = 0.27) and SPPB score (r = 0.24), grip strength (r = 0.33), and 6-minute walking distance (r = 0.26). Multiple linear regression analysis showed that the number of teeth was independently associated with physical frailty after adjusting for confounders. CONCLUSIONS: Oral health was closely associated with physical frailty, and nutritional status in patients with CVD; thus, it could be an important screening marker for early frailty symptoms and a predictor of future malnutrition risk.

  Feb. 2021, Journal of cardiology, 77(2) (2), 131 - 138, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effects of preoperative dental examination and oral hygiene instruction on surgical site infection after hepatectomy: a retrospective study.

  Takumi Hasegawa, Daisuke Takeda, Motofumi Tanaka, Rika Amano, Izumi Saito, Yasumasa Kakei, Akira Kimoto, Takumi Fukumoto, Masaya Akashi

  PURPOSE: This study retrospectively investigated relationships among risk factors and post-hepatectomy surgical site infection (SSI) and other complications in patients who underwent hepatectomy for hepatocellular carcinoma (HCC). METHODS: We included 334 patients who underwent hepatectomies for liver cancers between January 2011 and December 2015 in this study. We evaluated risk factors for SSI and other post-hepatectomy complication, including demographic factors, preoperative factors, and preoperative intervention including oral management, perioperative factors, and length of hospital stay, with univariate and multivariate analyses. The oral management intervention included self-care instructions, extraction of infected teeth, removal of dental plaques and calculus (scaling), professional mechanical teeth cleaning, removal of tongue coating, and cleaning of dentures. SSI was defined in accordance with the guideline issued by the Centers for Disease Control and Prevention; it included purulent discharge from any incision or organ space within 30 days postoperatively, with or without microbiological evidence. Complications of grade II or greater, according to the Clavien-Dindo classification, were regarded as postoperative complications. RESULTS: We found bacterial infection of ascites (Odds ratio (OR) = 13.72), lack of preoperative oral management intervention (OR = 10.17), and severe liver fibrosis (OR = 2.76) to be associated with SSI and severe liver fibrosis (OR = 2.28), hypoalbuminemia (OR = 2.02), blood transfusion (OR = 1.86), and longer operation time (OR = 1.80) to be associated with postoperative complications. CONCLUSIONS: Preoperative oral management may reduce the risk of SSI in patients with HCC who undergo hepatectomy.

  Feb. 2021, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(2) (2), 653 - 659, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The prospective evaluation and risk factors of dysphagia after surgery in patients with oral cancer.

  Takumi Hasegawa, Nanae Yatagai, Tatsuya Furukawa, Emi Wakui, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akiko Sakakibara, Ken-Ichi Nibu, Masaya Akashi

  BACKGROUND: This prospective study investigated the change of swallowing ability using the Swallowing Ability Scale System (SASS) and swallowing-related quality of life (QOL) by Performance Status Scale for Head and Neck Cancer patients (PSS-H&N). This study also investigated the risk factors for postoperative dysphagia in patients who received reconstructive surgery for oral cancer. SUBJECTS AND METHODS: This study included 64 patients (33 men and 31 women) who underwent radical surgery with neck dissection and reconstructive surgery for oral cancers between July 2014 and February 2018. We evaluated risk factors for poor swallowing ability after treatment, including demographic factors, preoperative factors and perioperative factors, with univariate and multivariate analyses. The change of swallowing ability by the SASS and swallowing-related QOL by PSS-H&N were evaluated prospectively prior to the initiation of surgery within 1 week and at 1 and 3 months after treatment. RESULTS: Advanced T stage (T3, 4) (odds ratio (OR) = 79.71), bilateral neck dissection (OR = 20.66) and the resection of unilateral or bilateral suprahyoid muscles (OR = 17.00) were associated with poor swallowing ability after treatment. The scores for time for food intake and Eating in Public were associated with decrease of QOL in the poor group. CONCLUSIONS: We propose that clinicians consider the risk factors identified in this study and pay close attention to the management of oral cancer patients with reconstructive surgery.

  Jan. 2021, Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 50(1) (1), 4 - 4, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effect of educational intervention on the appropriate use of oral antimicrobials in oral and maxillofacial surgery: a retrospective secondary data analysis.

  Junya Kusumoto, Atsushi Uda, Takeshi Kimura, Shungo Furudoi, Ryosuke Yoshii, Megumi Matsumura, Takayuki Miyara, Masaya Akashi

  BACKGROUND: In Japan, oral third-generation cephalosporins with broad-spectrum activity are commonly prescribed in the practices of dentistry and oral surgery. However, there are few reports on the appropriate use of antibiotics in the field of oral surgery. This study aimed to evaluate the appropriateness of antibiotic use before and after an educational intervention in the Department of Oral and Maxillofacial Surgery, Kobe University Hospital. METHODS: The use of oral antibiotics was investigated among inpatients and outpatients before and after an educational intervention conducted by the antimicrobial stewardship team. Additionally, the frequency of surgical site infection after the surgical removal of an impacted third mandibular molar under general anesthesia and the prevalence of adverse effects of the prescribed antibiotics were comparatively evaluated between 2013 and 2018. RESULTS: After the educational intervention, a remarkable reduction was noted in the prescription of oral third-generation cephalosporins, but increased use of penicillins was noted among outpatients. There was reduced use of macrolides and quinolones in outpatients. Although a similar trend was seen for inpatients, the use of quinolones increased in this population. Despite the change in the pattern of antibiotic prescription, inpatients who underwent mandibular third molar extraction between 2013 and 2018 did not show a significant increase in the prevalence of surgical site infections (6.2% vs. 1.8%, p = .336) and adverse effects of drugs (2.1% vs. 0%, p = .466). CONCLUSIONS: This study suggests that the judicious use of oral antibiotics is possible through conscious and habitual practice of appropriate antibiotic use. However, further investigation is required to develop measures for appropriate use of oral antibiotics.

  Jan. 2021, BMC oral health, 21(1) (1), 20 - 20, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Risk factors for osteoradionecrosis of the jaw in patients with head and neck squamous cell carcinoma.

  Hikaru Kubota, Daisuke Miyawaki, Naritoshi Mukumoto, Takeaki Ishihara, Megumi Matsumura, Takumi Hasegawa, Masaya Akashi, Naomi Kiyota, Hirotaka Shinomiya, Masanori Teshima, Ken-Ichi Nibu, Ryohei Sasaki

  BACKGROUND: To evaluate factors associated with osteoradionecrosis of the jaw (ORNJ) in patients with head and neck squamous cell carcinoma (HNSCC), focusing on jaw-related dose-volume histogram (DVH) parameters. METHODS: We retrospectively reviewed the medical records of 616 patients with HNSCC treated with curative-intent or postoperative radiation therapy (RT) during 2008-2018. Patient-related (age, sex, history of smoking or alcohol use, diabetes mellitus, performance status, pre-RT dental evaluation, pre- or post-RT tooth extraction), tumor-related (primary tumor site, T-stage, nodal status), and treatment-related (pre-RT surgery, pre-RT mandible surgery, induction or concurrent chemotherapy, RT technique) variables and DVH parameters (relative volumes of the jaw exposed to doses of 10 Gy-70 Gy [V10-70]) were investigated and compared between patients with and without ORNJ. The Mann-Whitney U test was used to compare RT dose parameters. Univariate and multivariate Cox regression analyses were used to assess factors associated with ORNJ development. Kaplan-Meier analyses were performed for cumulative ORNJ incidence estimation. RESULTS: Forty-six patients (7.5%) developed ORNJ. The median follow-up duration was 40 (range 3-145) months. The median time to ORNJ development was 27 (range 2-127) months. DVH analysis revealed that V30-V70 values were significantly higher in patients with than in those without ORNJ. In univariate analyses, primary tumor site, pre-RT mandible surgery, post-RT tooth extraction, and V60 > 14% were identified as important factors. In multivariate analyses, V60 > 14% (p = 0.0065) and primary tumor site (p = 0.0059) remained significant. The 3-year cumulative ORNJ incidence rates were 2.5% and 8.6% in patients with V60 ≤ 14% and > 14%, respectively (p < 0.0001), and 9.3% and 1.4% in patients with oropharyngeal or oral cancer and other cancers, respectively (p < 0.0001). CONCLUSIONS: V60 > 14% and oropharyngeal or oral cancer were found to be independent risk factors for ORNJ. These findings might be useful to minimize ORNJ incidence in HNSCC treated with curative RT.

  Jan. 2021, Radiation oncology (London, England), 16(1) (1), 1 - 1, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Bacterial Colonization of the Condyle in Patients with Advanced Mandibular Osteoradionecrosis: Analysis of Hemimandibulectomy Specimens.

  Daisuke Takeda, Kazunobu Hashikawa, Manabu Shigeoka, Maki Kanzawa, Nanae Yatagai, Satomi Arimoto, Junya Kusumoto, Takumi Hasegawa, Hiroto Terashi, Masaya Akashi

  Advanced mandibular osteoradionecrosis (ORN) sometimes requires extended resection (e.g., hemimandibulectomy). Bacterial infection contributes to ORN pathogenesis. To control infection and determine the extent of debridement required, an understanding of bacterial spread within sites of mandibular ORN is important. The current study used a histopathological approach to assess bacterial colonization in the mandibular condyle and elucidate possible paths of bacterial spread towards the mandibular condyle. Four hemimandibulectomy specimens were selected. Areas of bone destruction were macroscopically assessed and confirmed using hematoxylin and eosin staining. Bacterial presence within mandibular condyle was confirmed with Gram staining. Bone exposure was observed in the molar area in all specimens. Macroscopic bone destruction was apparent especially near the medial side of the cortical wall. Gram staining revealed bacterial colonization of the mandibular condyle in three of the four specimens. In conclusion, bacteria tended to spread posteriorly and through the medial side of the mandibular cortical wall. In patients with advanced ORN, the potential for bacterial colonization of the mandibular condyle should be considered during treatment.

  Corresponding, 2021, International journal of dentistry, 2021, 9998397 - 9998397, English, International magazine

  Scientific journal


• Transcutaneous Carbon Dioxide Decreases Immunosuppressive Factors in Squamous Cell Carcinoma In Vivo.

  Nanae Yatagai, Takumi Hasegawa, Rika Amano, Izumi Saito, Satomi Arimoto, Daisuke Takeda, Yasumasa Kakei, Masaya Akashi

  INTRODUCTION: In recent years, the tumour immunosuppressive mechanism has attracted attention as a cause of tumour chemoresistance. Although chemoresistance and immunosuppression of tumours have been reported to be associated with a hypoxic environment, effective treatments to improve hypoxia in tumours have not yet been established. We have previously applied carbon dioxide (CO2) to squamous cell carcinoma and have shown that improvement in local oxygenation has an antitumour effect. However, the effects of local CO2 administration on tumour immunosuppression, chemoresistance, and combination with chemotherapy are unknown. In this study, we investigated the effects of local CO2 administration on squamous cell carcinoma and the effects of combined use with chemotherapy, focusing on the effects on tumour immunosuppressive factors. METHODS: Human oral squamous cell carcinoma (HSC-3) was transplanted subcutaneously into the back of a nude mouse, and CO2 and cisplatin were administered. After administration twice a week for a total of 4 times, tumours were collected and the expression of tumour immunosuppressive factors (PD-L1, PD-L2, and galectin-9) was evaluated using real-time polymerase chain reaction and immunostaining. RESULTS: Compared with the control group, a significant decrease in the mRNA expression of PD-L1 was observed in both, CO2-treated and combination groups. Similarly, the expression of PD-L2 and galectin-9 decreased in the CO2-treated and combination groups. Furthermore, immunostaining also showed a significant decrease in the protein expression of tumour immunosuppressive factors in the CO2-treated and combination groups. CONCLUSION: It was confirmed that the tumour immunosuppressive factors decreased due to local CO2 administration to the mouse model. CO2 administration has the potential to improve the hypoxic environment in tumours, and combined use with chemotherapy may also improve tumour immunosuppression.

  2021, BioMed research international, 2021, 5568428 - 5568428, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The characteristics of oro-cervical necrotizing fasciitis-Comparison with severe cellulitis of oro-cervical region and necrotizing fasciitis of other body regions.

  Eiji Iwata, Junya Kusumoto, Naoki Takata, Shungo Furudoi, Akira Tachibana, Masaya Akashi

  BACKGROUND: Necrotizing fasciitis (NF) is an acute and life-threatening soft-tissue infection however rarely seen in oro-cervical region. Therefore, the details of oro-cervical NF (OCNF) are not well known. The purpose of this study was to investigate the characteristics of OCNF by comparing it with severe cellulitis of oro-cervical region (OCSC) or NF of other body regions (e.g., limb, perineum, and trunk) (BNF), respectively. MATERIALS AND METHODS: At first, various risk factors for OCNF in oro-cervical severe infection (OCSI; composed of OCNF and OCSC), including neutrophil-to-lymphocyte ratio (NLR) and Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score, were investigated by univariate and multivariate analyses. Next, the differences between OCNF and BNF, including inflammatory markers and mortality, were investigated. RESULTS: In the present study, 14 out of 231 OCSI patients had OCNF. Multivariate analyses of OCSI patients showed that NLR ≥15.3 and LRINEC score ≥6 points were significantly related to OCNF. During the same period, 17 patients had BNF. The OCNF group had significantly higher inflammatory markers than the BNF group when diagnosis, but significantly lower clinical stages at the time and mortality as outcomes. CONCLUSION: We found that compared to BNF, OCNF can be detected at lower clinical stage by using indexes, such as NLR and LRINEC score, besides clinical findings, which may help contributing to patient's relief.

  2021, PloS one, 16(12) (12), e0260740, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effects of a miconazole oral patch on preventing development of oral candidiasis in patients with head and neck cancer undergoing radiotherapy: results of a preliminary study quantifying the prevalence of Candida albicans in saliva

  Ryuichiro Funahara, Sakiko Soutome, Madoka Funahara, Shoma Tsuda, Takumi Hasegawa, Masahiro Umeda, Masaya Akashi

  2021, Supportive Care in Cancer

  Scientific journal


• Can four-dimensional computed tomography support diagnosis and treatment planning?: a case report before and after coronoidectomy.

  Wensu Huang, Masaya Akashi, Takuro Nishio, Noriyuki Negi, Akira Kimoto, Takumi Hasegawa

  INTRODUCTION: Elongated mandibular coronoid process is a rare condition defined as enlargement of the coronoid process. The only useful way to treat the mouth-opening limitation is resection of the elongated coronoid process. Four-dimensional CT (4DCT; three spatial dimensions plus time axis) is a novel imaging technique. Its usefulness of for evaluation of dynamic movements such as joint motion has been reported. Here, we show the potential usefulness of 4DCT evaluation in a patient with elongated mandibular coronoid process. CASE PRESENTATION: A 59-year-old female who suffered from mouth-opening difficulty and pressure during mouth opening was referred to our department. Elongation of the right coronoid process was evident in a panoramic X-ray image. The mandibular movement and temporal muscle motility before and after coronoidectomy in this patient on 4DCT could be evaluated. CONCLUSIONS: 4DCT is useful in the diagnosis and surgical outcome of elongated coronoid process.

  Corresponding, Dec. 2020, Oral and maxillofacial surgery, 24(4) (4), 515 - 520, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Does prophylactic antibiotic administration for tooth extraction affect PT-INR in patients taking warfarin?

  Eiji Iwata, Akira Tachibana, Junya Kusumoto, Naoki Takata, Takumi Hasegawa, Masaya Akashi

  BACKGROUND: Various antibiotics and analgesics have been reported to interact with warfarin. Reports that investigate the effects of medication taken for just a few days during tooth extraction on the prothrombin time-international normalized ratio are rare. METHODS: A total of 110 patients receiving long-term stable warfarin therapy underwent tooth extraction without interruption of warfarin treatment. INR values were measured 1 month before the tooth extraction, the day of the extraction, and 1 week after the extraction. We investigated the changes in INR values between the day of extraction and 1 week after extraction, as well as the various risk factors for increases in INR values. RESULTS: Before and after tooth extraction, the number of patients taking cefcapene pivoxil, amoxicillin, and azithromycin was 57, 36, and 8, respectively. Nine patients were administered ampicillin before tooth extraction and received amoxicillin after their tooth extraction. One week after tooth extraction, the INR values increased beyond the therapeutic range in 3 out of 110 patients (2.7%). The INR values before tooth extraction in these three patients were close to 3.0. The INR value increased by more than twice as much in 1 out of 110 patients (0.9%). CONCLUSION: Our results suggest that prophylactic antibiotic administration has little effect on INR values when patients on stable warfarin therapy undergo tooth extraction. Surgeons have to take attention if the patients whose INR values are close to 3.0 before their extraction.

  Nov. 2020, BMC oral health, 20(1) (1), 331 - 331, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 生体腎移植後患者に発症した歯性感染症によるガス壊疽の1例

  高田 直樹, 橘 進彰, 岩田 英治, 榎本 由依, 明石 昌也

  (一社)日本口腔感染症学会, Nov. 2020, 日本口腔感染症学会雑誌, 27(2) (2), 61 - 66, Japanese


• 生体腎移植後患者に発症した歯性感染症によるガス壊疽の1例

  高田 直樹, 橘 進彰, 岩田 英治, 榎本 由依, 明石 昌也

  (一社)日本口腔感染症学会, Nov. 2020, 日本口腔感染症学会雑誌, 27(2) (2), 61 - 66, Japanese


• 消化器外科SSI対策 経験からその検証へ 大腸癌術後SSIに対する周術期口腔ケアの予防効果に関する多施設共同研究

  延原 浩, 五月女 さき子, 林田 咲, 梅田 正博, 長谷川 巧実, 明石 昌也, 山田 慎一, 栗田 浩, 中原 寛和, 上田 順宏, 桐田 忠昭, 中村 知寿, 渋谷 恭之, 山口 泰平, 森 和代

  (一社)日本外科感染症学会, Oct. 2020, 日本外科感染症学会雑誌, 17(5) (5), 329 - 329, Japanese


• JCAD expression and localization in human blood endothelial cells.

  Manabu Shigeoka, Satomi Arimoto, Masaya Akashi

  Background: Junctional Cadherin 5 Associated (JCAD) is an endothelial, cell-cell junction protein, and its expression is associated with cardiovascular diseases including atherosclerosis and hypertension. However, to date, there are few studies confirming JCAD expression and precise localization in human tissues by immunohistochemical staining. Methods: JCAD expression and localization was assessed in four human submandibular gland (SMG) specimens by immunohistochemical staining. One specimen of SMG with sialoadenitis was accompanied by severe inflammation and fibrosis, while the other was largely normal. Other two SMGs were accompanied by severe fibrosis because of irradiation. Results: Immunohistochemical analysis of human SMGs revealed JCAD localization at the blood endothelial cell-cell junctions. JCAD expression was more evident in microvessels and arteries in areas affected by inflammation. Conclusions: The localization of JCAD at endothelial cell-cell junctions was confirmed in human tissues. JCAD expression may be affected by pathological conditions.

  Corresponding, Oct. 2020, Heliyon, 6(10) (10), e05121, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Phase I dose-escalation trial of S-1 combined with carbon-ion radiotherapy for sinonasal squamous cell carcinoma.

  Daiki Takahashi, Yusuke Demizu, Sung Chul Park, Yoshiro Matsuo, Nor Shazrina Sulaiman, Kazuki Terashima, Sunao Tokumaru, Masaya Akashi, Tomoaki Okimoto

  This study aimed to determine the maximum tolerance dose (MTD) and to estimate the recommended dose (RD) of concomitant S-1 with carbon-ion radiotherapy (RT) for sinonasal squamous cell carcinoma (SCC). Nine patients with sinonasal SCC received carbon-ion RT with escalating doses of S-1 according to phase I methods. Doses of 40, 60 and 80 mg/m2/day were administered twice daily in dose levels 1, 2 and 3, respectively, from days 1 to 14 and 22 to 35. Carbon-ion RT was administered at a dose of 70.4 Gy (relative biological effectiveness) in 32 fractions, 5 days a week. Two patients developed grade 3 acute dermatitis. However, none developed dose-limiting toxicities. Therefore, the MTD of S-1 could not be determined; the RD was estimated to be 80 mg/m2/day with concurrent carbon-ion RT. Partial response and stable disease were noted in 5 and 4 patients, respectively. The 2-year overall survival and local control rates were 56 and 74%, respectively. Overall, 2 patients developed ≥grade 3 late toxicities; among them, 1 patient developed grade 3 cataract and the other developed grade 4 cataract, optic nerve disorder and hearing impairment. To the best of our knowledge, this phase I study is the first clinical trial to evaluate concomitant S-1 with carbon-ion RT for sinonasal SCC. The MTD of S-1 could not be determined, and the RD was estimated to be 80 mg/m2/day. This study demonstrated a manageable safety profile for this combination. The observed outcomes may facilitate further evaluation of this novel therapy.

  Sep. 2020, Journal of radiation research, 61(5) (5), 733 - 739, English, International magazine

  Scientific journal


• 膵頭十二指腸切除術における周術期口腔機能管理の術後合併症予防効果

  山口 泰平, 高島 裕之, 森田 麻希, 渋谷 恭之, 五月女 さき子, 林田 咲, 村田 真穂, 梅田 正博, 延原 浩, 長谷川 巧実, 明石 昌也, 兒島 由佳, 小西 尚晃, 中原 寛和, 山田 慎一, 栗田 浩, 森 和代, 於保 孝彦

  (一社)日本口腔ケア学会, Sep. 2020, 日本口腔ケア学会雑誌, 14(3) (3), 114 - 114, Japanese


• 周術期口腔ケアによる胃癌術後合併症予防効果に関する臨床的検討

  高島 裕之, 五月女 さき子, 林田 咲, 村田 真穂, 梅田 正博, 延原 浩, 長谷川 巧実, 明石 昌也, 上田 順宏, 下辻 寛子, 桐田 忠昭, 小西 尚晃, 中原 寛和, 山田 慎一, 栗田 浩, 山口 泰平, 森 和代, 渋谷 恭之

  (一社)日本口腔ケア学会, Sep. 2020, 日本口腔ケア学会雑誌, 14(3) (3), 123 - 123, Japanese


• 口腔ケアのエビデンスを検証するためにはどのような研究をすればよいのか アカデミア臨床研究環境のこれまで 臨床研究法施行の背景

  筧 康正, 長谷川 巧実, 明石 昌也

  (一社)日本口腔ケア学会, Sep. 2020, 日本口腔ケア学会雑誌, 14(3) (3), 53 - 54, Japanese


• 大腸癌術後合併症に対する周術期口腔機能管理の予防効果に関する多施設共同研究

  延原 浩, 五月女 さき子, 林田 咲, 村田 真穂, 梅田 正博, 長谷川 巧実, 明石 昌也, 山田 慎一, 栗田 浩, 小西 尚晃, 中原 寛和, 上田 順宏, 下辻 寛子, 桐田 忠昭, 中村 知寿, 渋谷 恭之, 山口 泰平, 森 和代

  (一社)日本口腔ケア学会, Sep. 2020, 日本口腔ケア学会雑誌, 14(3) (3), 122 - 122, Japanese


• Clinical investigation on sarcoma in oral and maxillofacial regions: A multicenter retrospective analysis in Japan

  Ryuichi Itoh, Shin ichi Yamada, Takumi Hasegawa, Nobuhiro Yamakawa, Yuya Denda, Hiroki Otagiri, Masaya Okura, Souichi Yanamoto, Masaya Akashi, Tadaaki Kirita, Yoshihide Ota, Masahiro Umeda, Hiroshi Kurita

  Sep. 2020, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 32(5) (5), 356 - 359

  Scientific journal


• Intraepithelial Macrophage Expressing CD163 Is a Histopathological Clue to Evaluate the Malignant Potency of Oral Lichenoid Condition: A Case Report and Immunohistochemical Investigation.

  Manabu Shigeoka, Yu-Ichiro Koma, Maki Kanzawa, Masaya Akashi, Hiroshi Yokozaki

  Oral lichenoid conditions (OLC), including oral lichen planus (OLP), oral lichenoid lesions and oral lichenoid dysplasia, differ in pathogenesis and biological malignancy. However, distinguishing them based on clinical or histological features is difficult. It is well known that CD163+ macrophages are associated with oral cancer aggressiveness. We recently demonstrated that CD163+ macrophages of noncancerous lesions infiltrate the stroma, not the intraepithelial area. In this report, we describe a case of OLC that was not detected as malignant by the first local biopsy. Furthermore, we evaluated the malignant potency of OLC by retrospectively comparing the histological findings between local biopsy and resected specimens focusing on CD163+ macrophages. A 72-year-old man with a white lesion in the unilateral buccal mucosa was diagnosed with OLP through the biopsy although invasive cancer was detected two years later. Intraepithelial CD163+ macrophages were found not only on the resected specimen but also biopsy. This is the first report to demonstrate that intraepithelial CD163+ macrophages may be noteworthy indicators to identify the malignant potency of OLC.

  MDPI AG, Aug. 2020, Diagnostics (Basel, Switzerland), 10(9) (9), 624 - 624, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 全身麻酔導入時にロクロニウムによるアナフィラキシーをきたした1例

  高田 直樹, 橘 進彰, 高井 美玲, 榎本 由依, 岩田 英治, 黄 文蘇, 明石 昌也

  (一社)日本有病者歯科医療学会, Aug. 2020, 有病者歯科医療, 29(3) (3), 75 - 80, Japanese


• Which symptoms negatively affect the oral health-related quality of life in patients with osteonecrosis of the jaw?

  Takumi Sato, Junya Kusumoto, Daisuke Takeda, Megumi Kishimoto, Masahiko Kashin, Shungo Furudoi, Masaya Akashi

  OBJECTIVES: One of the treatment goals for osteonecrotic lesions of the jaw, such as medication-related osteonecrosis of the jaw (MRONJ) or osteoradionecrosis (ORN), is restoration of quality of life (QOL). This study aimed to identify symptoms that negatively affect QOL in patients with unhealed MRONJ or ORN. STUDY DESIGN: This cross-sectional study included patients who were previously diagnosed with MRONJ or ORN and who underwent treatment at the Kobe University Hospital between June 2015 and February 2016. Patient QOL was measured by using the Oral Health Impact Profile (OHIP-14). The predictor variable was disease status (stage and healing). The outcome variable was OHIP-14. One-way analysis of variance and Tukey's test were performed. RESULTS: The study included 74 patients (37 men and 37 women; mean age 70 years). Although there was no significant difference between the OHIP-14 scores of unhealed MRONJ and ORN (stages 1-3) and those of healed ones, the "worsened sense of taste" resulted in significant differences among stages in patients with unhealed MRONJ (P = .027) and the "painful mouth aching" in patients with unhealed ORN (P = .041). CONCLUSIONS: Worsened sense of taste and pain negatively affected QOL in patients with unhealed MRONJ and ORN.

  Corresponding, Aug. 2020, Oral surgery, oral medicine, oral pathology and oral radiology, 130(2) (2), 175 - 180, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Postoperative adjuvant therapy for patients with loco-regionally advanced oral squamous cell carcinoma who are at high risk of recurrence

  S. Yanamoto, Y. Denda, Y. Ota, T. Hasegawa, M. Akashi, M. Okura, S. I. Yamada, H. Kurita, N. Yamakawa, T. Kirita, M. Ueda, M. Umeda

  Jul. 2020, International Journal of Oral and Maxillofacial Surgery, 49(7) (7), 848 - 853

  Scientific journal


• Prevalence of and risk factors for postoperative hemorrhage after lower third molar extraction on warfarin therapy: a multicenter retrospective study in Japan.

  Shin-Ichi Yamada, Takumi Hasegawa, Sakiko Soutome, Hitoshi Yoshimura, Masaaki Miyakoshi, Nobuhiro Ueda, Kenjiro Okamoto, Sumiyo Hishida, Satoshi Rokutanda, Hirokazu Nakahara, Shigeyuki Fujita, Masaya Akashi, Yoshimasa Kitagawa, Tadaaki Kirita, Yasuyuki Shibuya, Masahiro Umeda, Hiroshi Kurita

  Postoperative hemorrhage after tooth extraction is a critical and clinically important issue for clinicians and patients receiving anticoagulants. The purpose of the present study was to investigate the prevalence of and risk factors for postoperative hemorrhage after lower third molar extraction in Japanese patients receiving warfarin therapy. A total of 142 patients who underwent lower third molar extraction between January 2010 and December 2016 were included, and their medical records were retrospectively reviewed. The prevalence of and risk factors for postoperative hemorrhage were investigated. The prevalence of postoperative hemorrhage after lower third molar extraction was significantly higher in patients receiving warfarin than in healthy subjects (21.8% vs 0.7%, P < 0.001). The cutoff value for PT-INR was 2.11 based on a receiver-operating characteristic analysis. A multivariate analysis indicated that an elevated PT-INR value [hazard ratio (HR) 3.798, 95% confidence interval (CI) 1.400-10.467, P < 0.01], preoperative antibiotic administration (HR 4.434, 95% CI 1.591-14.775, P < 0.01), difficulties with intraoperative hemostasis (HR 16.298, 95% CI 2.986-110.677, P < 0.01), and higher serum creatinine levels (HR 7.465, 95% CI 1.616-39.576, P < 0.05) are significant predictors of postoperative hemorrhage after lower third molar extraction. Multivariate correlations were observed between risk factors including an elevated PT-INR value, preoperative antibiotic administration, and higher serum creatinine levels, and postoperative hemorrhage after lower third molar extraction in patients receiving warfarin therapy. Clinicians need to consider these risk factors for postoperative hemorrhage after the lower third molar extraction and monitor PT-INR in patients receiving warfarin therapy.

  Jul. 2020, Odontology, 108(3) (3), 462 - 469, English, Domestic magazine

  [Refereed]

  Scientific journal


• Neutrophil-lymphocyte ratio associated with poor prognosis in oral cancer: a retrospective study.

  Takumi Hasegawa, Tomoya Iga, Daisuke Takeda, Rika Amano, Izumi Saito, Yasumasa Kakei, Junya Kusumoto, Akira Kimoto, Akiko Sakakibara, Masaya Akashi

  BACKGROUND: Prognostic biomarkers provide essential information about a patient's overall outcome. However, existing biomarkers are limited in terms of either sample collection, such as requiring tissue specimens, or the process, such as prolonged time for analysis. In view of the need for convenient and non-invasive prognostic biomarkers for oral cancer, we aimed to investigate the prognostic values of neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio in patient survival. We also aimed to explore the associations of these ratios with the clinicopathologic characteristics of Japanese oral squamous cell carcinoma patients. METHODS: This study was a non-randomized retrospective cohort study in a tertiary referral center. We included 433 patients (246 men, 187 women) who underwent radical surgery for oral cancers between January 2001 and December 2013. We evaluated various risk factors for poor prognosis including neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio with univariate and multivariate analyses. The disease-specific survival and overall survival rates of patients were compared among the factors and biomarkers. RESULTS: In multivariable Cox proportional hazards analysis, high neutrophil-to-lymphocyte ratio (hazard ratio 2.87, 95% confidence interval 1.59-5.19, P <  0.001), moderately or poorly differentiated histology (hazard ratio 2.37, 95% confidence interval 1.32-4.25, P <  0.001), and extranodal extension (hazard ratio 1.95, 95% confidence interval 1.13-3.35, P = 0.016) were independent predictors of disease-specific survival. High neutrophil-to-lymphocyte ratio (hazard ratio 2.30, 95% confidence interval 1.42-3.72, P <  0.001), moderately or poorly differentiated (hazard ratio 1.72, 95% confidence interval 1.07-2.76, P = 0.025), and extranodal extension (hazard ratio 1.79, 95% confidence interval 1.13-2.84, P = 0.013) were independent predictors of overall survival. CONCLUSIONS: Neutrophil-to-lymphocyte ratio might be a potential independent prognostic factor in Japanese oral squamous cell carcinoma patients.

  Jun. 2020, BMC cancer, 20(1) (1), 568 - 568, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Clinical significance of the G8 screening tool in elderly patients with oral squamous cell carcinoma.

  Shin-Ichi Yamada, Takumi Hasegawa, Kohei Okuyama, Nobuhiro Yamakawa, Masaya Okura, Masao Hashidume, Souichi Yanamoto, Masaya Akashi, Tadaaki Kirita, Masahiro Umeda, Hiroshi Kurita

  OBJECTIVES: The present study investigated the clinical significance of the G8 screening tool in elderly oral squamous cell carcinoma (OSCC) patients using a multicenter analysis. MATERIALS AND METHODS: The medical records of 438 primary OSCC patients aged 75 years and older were retrospectively reviewed. To examine the clinical significance of the G8 screening tool in elderly OSCC patients, self-reliance (SR) rates and prognostic factors were statistically analyzed. RESULTS: The mean score of the G8 screening tool was 10.9 ± 2.93. The SR cut-off value of the G8 score was 9.5 in a receiver operating characteristic curve analysis. Five-year overall survival rates were 40.1% in patients with a G8 score < 9.5 and 58.4% in those with a G8 score ≥ 9.5 (p < 0.01). Five-year cancer-specific rates were 34.3% in patients with a G8 score < 9.5 and 55.7% in those with a G8 score ≥ 9.5 (p < 0.01). Five-year SR rates were 40.7% in patients with a G8 score < 9.5 and 55.3% in those with a G8 score ≥ 9.5 (p < 0.05). A multivariate analysis identified an advanced age (≥ 80 vs < 80; HR, 1.437; 95%CI, 1.181-1.843; p < 0.01), poorer ECOG-PS (2-4 vs 0-1; HR, 1.560; 95%CI, 1.14-2.106; p < 0.01), and standard treatment (non-standard therapy vs standard therapy; HR, 0.598; 95%CI, 0.405-0.910; p < 0.05) as significant independent prognostic factors for SR. A lower G8 score was associated with poorer SR (≥ 9.5 vs < 9.5; HR, 0.765; 95%CI, 0.575-1.034; p = 0.081). CONCLUSION: The clinical significance of the G8 score for elderly OSCC patients was demonstrated and its combination with ECOG-PS may be useful for assessing their prognoses.

  Jun. 2020, Clinical oral investigations, 24(6) (6), 1953 - 1961, English, International magazine

  [Refereed]

  Scientific journal


• Extent of neck dissection for patients with clinical N1 oral cancer.

  Yasumasa Kakei, Hirokazu Komatsu, Tsutomu Minamikawa, Takumi Hasegawa, Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Ken-Ichi Nibu, Masaya Akashi

  BACKGROUND: No clear consensus has been reached on the indication of supraomohyoid neck dissection (SOHND) for clinically positive lymph-node metastasis. PATIENTS: Consecutive 100 patients with previously untreated oral cancer treated at Kobe University Hospital were included in this study. All patients were clinically staged as anyTN1M0 and underwent radical dissection of the primary site and level I-V neck dissection as the initial treatment. RESULTS: None of the 100 patients had pathological lymph-node metastasis (pLN) to level V. pLN to level IV was observed in two patients with tongue cancer in whom clinical lymph-node metastasis was preoperatively observed at level II. CONCLUSIONS: Level V may be excluded in the neck dissection for patients with N1 oral cancers. Level IV dissection should be considered in the patient with tongue cancer and clinical lymph-node metastasis at level II.

  Jun. 2020, International journal of clinical oncology, 25(6) (6), 1067 - 1071, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Intraepithelial CD163+ macrophages in tongue leukoplakia biopsy: A promising tool for cancer screening.

  Manabu Shigeoka, Yu-Ichiro Koma, Takayuki Kodama, Mari Nishio, Masaya Akashi, Hiroshi Yokozaki

  OBJECTIVE: Oral leukoplakia has mixed and differing histopathological features, and it is thus difficult to reach an accurate histological diagnosis of oral leukoplakia based on a local biopsy alone. We recently demonstrated the significance of CD163+ macrophages in oral carcinogenesis. Herein we sought to determine whether CD163+ macrophages in biopsy specimens of oral leukoplakia help identify the overall histological nature of the lesion. PATIENTS AND METHODS: Twenty-six patients with tongue leukoplakia who underwent a histological examination by both a preoperative local biopsy and consecutive total excision were enrolled. We evaluated clinicopathological factors and the expression of CD163+ macrophages based on a retrospective comparison of the histological diagnostic concordance between the biopsies and excisions. RESULTS: Seventeen patients (diagnostic-agreement group) were diagnosed with squamous intraepithelial lesion based on both the biopsy and the excision. Nine patients (diagnostic-discrepancy group) were diagnosed with invasive cancer by excision, although invasive cancer was not observed in their biopsy specimens. Compared to the diagnostic-agreement group, the diagnostic-discrepancy group had more tongue leukoplakia with non-homogenous or high numbers of intraepithelial CD163+ macrophages. CONCLUSION: The evaluation of intraepithelial CD163+ macrophages in local biopsy specimens from tongue leukoplakia patients is a promising tool for cancer screening.

  Apr. 2020, Oral diseases, 26(3) (3), 527 - 536, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Factors associated with severe oral mucositis and candidiasis in patients undergoing radiotherapy for oral and oropharyngeal carcinomas: a retrospective multicenter study of 326 patients.

  Mika Nishii, Sakiko Soutome, Akiko Kawakita, Hirokazu Yutori, Eiji Iwata, Masaya Akashi, Takumi Hasegawa, Yuka Kojima, Madoka Funahara, Masahiro Umeda, Takahide Komori

  PURPOSE: The present retrospective multicenter study intended to investigate the factors associated with severe oral mucositis and candidiasis in patients undergoing radiotherapy for oral and oropharyngeal carcinomas. METHODS: A total of 326 patients who underwent radiotherapy for oral and oropharyngeal cancers were enrolled in the study. The patients' age, sex, body mass index, primary site, diabetes, serum albumin, creatinine, hemoglobin, leukocyte and lymphocyte, concurrent cisplatin or cetuximab, method of radiation, total radiation dose, feeding route, use of spacers, pilocarpine hydrochloride, and corticosteroid ointment were examined, and the associations of each variable with oral mucositis and candidiasis were analyzed by multivariate Cox regression analysis. RESULTS: Grade 3 oral mucositis occurred in 136 (41.7%) patients. Male sex, oropharyngeal cancer, low hemoglobin levels, low leukocytes or lymphocytes, concurrent cisplatin or cetuximab, and oral feeding were found to be significantly associated with a higher incidence of severe oral mucositis. Oral candidiasis occurred in 101 (31.0%) patients. Oropharyngeal cancer, low leukocyte count, and oral mucositis of grade 2 or higher were found to be significantly associated with a higher incidence of oral candidiasis. The use of a topical steroid ointment was not found to be a risk factor for oral candidiasis. CONCLUSIONS: The present retrospective study demonstrated that certain factors may predispose patients with oral and oropharyngeal cancers receiving radiotherapy to develop severe oral mucositis and oral candidiasis. A preventive strategy for severe oral mucositis needs to be established in the future for high-risk cases.

  Mar. 2020, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 28(3) (3), 1069 - 1075, English, International magazine

  [Refereed]

  Scientific journal


• Tooth Loss Predicts Long-Term Prognosis of Esophageal Cancer After Esophagectomy.

  Susumu Miura, Tetsu Nakamura, Takumi Hasegawa, Yukiko Miura, Gosuke Takiguchi, Naoki Urakawa, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Yoshiko Matsuda, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Satoshi Suzuki, Masaya Akashi, Yoshihiro Kakeji

  BACKGROUND: Oral health is associated with various diseases, including cancer. Tooth loss is a simple and objective index of oral health. OBJECTIVE: The purpose of this study was to investigate the association between preoperative tooth loss and esophageal cancer prognosis after esophagectomy. METHODS: This study included 191 patients who underwent esophagectomy for esophageal cancer after perioperative dental evaluation and oral care at Kobe University Hospital from April 2011 to March 2016. Patients were divided into two groups: Group A (tooth loss < 7) and Group B (tooth loss ≥ 7). Three-year overall survival (OS) and multivariate analysis were performed, along with subgroup analysis for elderly patients (age ≥ 65 years). RESULTS: The 3-year OS rate was 68.1% in Group A (104 patients) and 49.2% in Group B (87 patients). Group A had significantly higher OS than Group B (p = 0.002), and there were no significant differences in sex and clinical T or N stage between the two groups. However, the mean age of Group A was younger than that of Group B (64.2 vs. 68.5 years; p = 0.0002). Among elderly patients, the 3-year OS rate was 68.2% in Group A (55 patients) and 45.1% in Group B (65 patients) [p = 0.003]. Multivariate analysis that included age demonstrated that tooth loss is an independent prognostic factor (hazard ratio 1.87, 95% confidence interval 1.22-2.87), in addition to clinical T stage and preoperative serum albumin. CONCLUSION: Tooth loss is an independent prognostic factor for esophageal cancer after esophagectomy.

  Mar. 2020, Annals of surgical oncology, 27(3) (3), 683 - 690, English, International magazine

  [Refereed]

  Scientific journal


• CD163+ Foamy Macrophages Are Associated with the Morphogenesis of Oral Verruciform Xanthoma through Angiogenesis by VEGF Expression: An Immunohistochemical Study.

  Manabu Shigeoka, Yu-Ichiro Koma, Takayuki Kodama, Mari Nishio, Masaya Akashi, Hiroshi Yokozaki

  Oral verruciform xanthoma (OVX) is an uncommon benign lesion that is characterized histologically by the accumulation of several foamy macrophages in the lamina propria papillae. The pathogenesis of OVX has not been completely elucidated, although the significance of macrophage polarization (M1, tumor suppression; and M2, tumor promotion) and the contribution of M2 macrophages to angiogenesis are well established. This study investigated the role of foamy macrophages in OVX, with a focus on angiogenesis. Four patients who underwent surgical excision or total excisional biopsy for OVXs were enrolled in this study. We evaluated the expression of the macrophage markers CD68 (broad) and CD163 (M2) and the CD34-positive microvessel density (MVD) of OVXs. The foamy macrophages of all patients exhibited positivity to CD68 and CD163. We evaluated the MVD and the expression of the vascular endothelial growth factor (VEGF) based on histological architecture. The MVD of all OVX cases was significantly higher than that of the corresponding normal epithelia. Interestingly, the MVD of verrucous-type OVX cases was higher than that of the other type. VEGF was expressed on foamy macrophages in all cases. Overall, the foamy macrophages expressing CD163 were associated with the morphogenesis of OVX through the process of angiogenesis by VEGF expression.

  Feb. 2020, Dentistry journal, 8(1) (1), English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Gold Nanoparticles Enhance EGFR Inhibition and Irradiation Effects in Head and Neck Squamous Carcinoma Cells.

  Masahiko Kashin, Yasumasa Kakei, Shun Teraoka, Takumi Hasegawa, Akinobu Yamaguchi, Takao Fukuoka, Ryohei Sasaki, Masaya Akashi

  Cetuximab, an epidermal growth factor receptor inhibitor (EI), is currently the only targeted molecular therapy used in combination with radiotherapy for head and neck squamous cell carcinoma (HNSCC). Gold nanoparticles (AuNPs) are expected to enhance radiotherapy effects in cancers. To investigate whether AuNPs combined with AG1478, an EI, enhanced irradiation effects on HNSCC cells, we first examined AG1478 adsorption on AuNP surfaces, using surface-enhanced Raman scattering, which indicated an adsorption equilibrium of AG1478 to AuNPs. We then used transmission electron microscopy to find internalization rates of AuNP alone and AuNP+AG1478; we found that intracellular uptake of AuNP alone and AuNP+AG1478 did not significantly differ. We compared cell numbers, proliferation, apoptosis, and migration between control cells and those treated with or without 60 nm AuNP (1.0 nM), AG1478 (0.5 μM), and irradiation (4 Gy). We found that AuNP+AG1478 inhibited proliferation more than AG1478 alone; the combination of irradiation+AuNP+AG1478 significantly reduced total cell numbers compared with the combination of irradiation+AuNP; AuNP+AG1478 increased apoptotic reaction to irradiation; the combinations of AuNP+AG1478 and irradiation+AuNP induced more apoptosis than AG1478+irradiation. Whereas AuNP+AG1478 enhanced cytotoxicity in human HNSCC cells by inhibiting proliferation, irradiation+AuNP enhanced cytotoxicity by inducing apoptosis.

  2020, BioMed research international, 2020, 1281645 - 1281645, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effect of low-intensity pulsed ultrasound after intraoral vertical ramus osteotomy.

  Satomi Arimoto, Takumi Hasegawa, Daisuke Takeda, Chizu Tateishi, Masaya Akashi, Shungo Furudoi, Takahide Komori

  OBJECTIVE: The present study investigated the effect of low-intensity pulsed ultrasound (LIPUS) on long-term osseous healing of the cleavage space between bone fragments after intraoral vertical ramus osteotomy (IVRO). STUDY DESIGN: Patients undergoing IVRO were randomly assigned to the LIPUS group (n = 12) or the control group (n = 9) after surgery. LIPUS treatments were applied daily to the cleavage space between bone fragments for 3 weeks. We observed 3-dimensional quantitative color mapping of the whole mandible created by computed tomography (CT) data at 1 month, 6 months, and 1 year postoperatively. On the basis of CT values, the color grades were classified as D1 to D5 by using the Misch criteria. We then calculated mean CT values and rated each color grade in different selection ranges. RESULTS: The mean CT values of the LIPUS group were significantly higher than those of the control group at 1 month, 6 months and 1 year postoperatively (P < .01). The color grades of the cleavage between bone fragments increased from D5 to D1 over time. CONCLUSIONS: Our results indicated that LIPUS promoted osseous healing after IVRO, thus improving bone density and offering clinical benefits.

  Dec. 2019, Oral surgery, oral medicine, oral pathology and oral radiology, 128(6) (6), 581 - 589, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 「口腔がん治療における周術期口腔機能管理とは?」 口腔・中咽頭がん放射線治療時の口腔粘膜炎と口腔カンジダ症のリスク因子 多施設共同研究による326例の解析結果

  西井 美佳, 五月女 さき子, 長谷川 巧実, 柚鳥 宏和, 川北 晃子, 兒島 由佳, 船原 まどか, 梅田 正博, 明石 昌也, 古森 孝英

  (一社)日本口腔腫瘍学会, Sep. 2019, 日本口腔腫瘍学会誌, 31(3) (3), 111 - 116, Japanese

  [Refereed]


• [総説]口腔・中咽頭がん患者の放射線性顎骨壊死発症リスク因子について：多施設共同後ろ向き研究の結果より

  兒島由桂, 河岡有美, 川下由美子, 山田慎一, 栗田 浩, 長谷川巧実, 古森孝英, 明石昌也, 上田順宏, 桐田忠昭, 高島裕之, 渋谷恭之, 梅田正博

  (一社)日本口腔腫瘍学会, Sep. 2019, 日本口腔腫瘍学会誌, 31(3) (3), 117 - 120, Japanese


• Dental intervention against osteoradionecrosis of the jaws in irradiated patients with head and neck malignancy: a single-arm prospective study.

  Yumi Muraki, Masaya Akashi, Yasuo Ejima, Takumi Hasegawa, Daisuke Miyawaki, Hirotaka Shinomiya, Mika Nishii, Naoki Otsuki, Ryohei Sasaki, Ken-Ichi Nibu, Takahide Komori

  BACKGROUND: The purpose of this study was to investigate the effectiveness of dental intervention before and after radiation therapy (RT) for head and neck malignancy on prevention of osteoradionecrosis (ORN) of the jaws. METHODS: This is a single-arm prospective study according to intervention protocol of prophylactic dental extraction before RT and routine follow-up after RT. The primary endpoint was the occurrence of jawbone exposure during the first 2 years after RT. RESULTS: Sixty-seven patients were assessed. Before RT, 144 teeth among 39 patients (58%) were prophylactically extracted. The occurrence of transient jawbone exposure during the first 2 years after RT was 7%. Because those jawbone exposures healed with intervention after RT, no jawbone exposure was found at 2 years after RT. CONCLUSIONS: Dental intervention both before and after RT seemed to be important to prevent ORN development. Further studies in larger cohorts are necessary.

  Corresponding, Sep. 2019, Oral and maxillofacial surgery, 23(3) (3), 297 - 305, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effect of size difference between hemiglossectomy and reconstruction flap on oral functions: A retrospective cohort study.

  Akiko Sakakibara, Junya Kusumoto, Shunsuke Sakakibara, Takumi Hasegawa, Masaya Akashi, Tsutomu Minamikawa, Shungo Furudoi, Kazunobu Hashikawa, Takahide Komori

  BACKGROUND AND OBJECTIVE: Forearm free flaps are used after hemiglossectomy. However, no investigation has been performed on whether oral functions are better preserved when sizes of the resection and reconstruction flap are exact matches, or whether the size of the resection should be changed. We aimed to retrospectively examine whether size differences between the resection and reconstruction flap affect speech and swallowing functions postoperatively, and to determine whether there are more favorable flap size ratios. METHODS: This is a retrospective cohort study of patients undergoing hemiglossectomy using a forearm free flap between 2006 and 2016 at Kobe University Hospital, Japan. The effect of size difference between the resection and reconstruction flap on maintained oral function was assessed. Speech and swallowing functions were assessed, and their correlation with the ratio of the flap size to that of the resected area was determined. With these data, distribution maps of the relationship between the functional level and reconstructed dimension ratio were prepared. The more suitable reconstructed dimension ratio was examined and evaluated. The Fisher exact test, Kruskal-Wallis test, and Scheffe test were used in statistical analyses. RESULTS: Eighty-eight patients underwent hemiglossectomy using a forearm free flap during a 10-year period. Of these cases, 66 patients were included in this study, while 22 were excluded. The ratio of the area of the reconstruction flap to that of the resection site was 0.59-2.79 (median: 1.61). Sixty patients had flaps greater than the resection area, whereas 6 had smaller flaps. Significant differences were found in speech intelligibility and swallowing function when the reconstructed dimension ratio was categorized as follows: ≤1.3, 1.3-1.8, and ≥1.8. CONCLUSION: Our findings suggest that postoperative deterioration of oral functions after hemiglossectomy could be reduced if reconstruction is performed using a forearm free flap with a surface area 1.3 to 1.8 times greater than that of the resection area.

  Jul. 2019, Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 72(7) (7), 1135 - 1141, English, International magazine

  Scientific journal


• Dental Rehabilitation for Free Fibula Flap-Reconstructed Mandible with Scar Contracture: A Technical Note.

  Masaya Akashi, Kousuke Matsumoto, Daisuke Takeda, Junya Yamashita, Nanae Yatagai, Kazunobu Hashikawa, Takahide Komori

  Dental rehabilitation with osseointegrated implants in reconstructed mandibles is a common procedure, but the technique still requires improvement, especially in its reliability and technical simplification. We herein report dental rehabilitation of a free fibula-reconstructed mandible with scar contracture. A vestibuloplasty technique with application of a polyglycolic acid (PGA) sheet is described. The implants were inserted into a viable fibula flap with severe scar contracture of the overlying epithelium resulting from vascular instability in skin paddle. Only the fibula periosteum was sutured after implant insertion; exposed surfaces were covered with a combination of PGA sheet and fibrin sealant. The area with PGA sheet coverage gradually healed with moderate contracture. The epithelium around the almost implants became immobilized. The implant-supported removable partial denture with custom titanium bar was acceptable. Dental rehabilitation is possible for reconstructed mandibles with severe scar contracture. Application of a PGA sheet may be useful for vestibuloplasty in patients with reconstructed mandibles.

  Jun. 2019, Dentistry journal, 7(3) (3), English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• A radiologic evaluation of the incidence and morphology of maxillary sinus septa in Japanese dentate maxillae.

  Daisuke Takeda, Takumi Hasegawa, Izumi Saito, Satomi Arimoto, Masaya Akashi, Takahide Komori

  PURPOSE: Evaluation of the inner aspect of the maxillary sinus is important for the success of a sinus lift procedure. The most common surgical complication is perforation of the Schneiderian membrane, which is thought to occur because of the presence of maxillary sinus septa. Therefore, we retrospectively investigated the incidence and morphology of maxillary sinus septa using multiplanar reformatted computed tomographic (CT) images from dentate Japanese patients. METHODS: A total of 276 patients and 552 maxillary sinus segments were evaluated. The maxillary sinus septa were divided into four locations: forefront, anterior, middle, and posterior. The heights of the septa were measured at three sites from the deepest point of the sinus floor: lateral, mid-point, and medial. RESULTS: Sinus septa were identified in 191 of 552 (34.6%) maxillary sinus segments obtained from 111 of 276 (40.2%) patients. One unilateral septum was most commonly detected, and the sinus septa were most often located in the middle of the maxillary sinus. The average height of the identified septa was 8.69 ± 4.68 mm (mean ± standard deviation). CONCLUSION: Multiplanar reformatted CT images can identify maxillary sinus septa in any plane. The height of maxillary sinus septa in the dentate maxillae was higher than detected in previous studies. Appropriate treatment planning using CT images should be considered to prevent surgical complications.

  Jun. 2019, Oral and maxillofacial surgery, 23(2) (2), 233 - 237, English, International magazine

  Scientific journal


• Long-Term Effects on Volume Change in Musculocutaneous Flaps after Head and Neck Reconstruction.

  Akiko Sakakibara, Junya Kusumoto, Shunsuke Sakakibara, Takumi Hasegawa, Masaya Akashi, Tsutomu Minamikawa, Shungo Furudoi, Kazunobu Hashikawa, Takahide Komori

  OBJECTIVE:  Musculocutaneous flap reconstruction surgery is one of the standard procedures following head and neck cancer resection. However, no previous studies have classified flaps in terms of muscle and fat or examined them after long-term follow-up. The purpose of this study was to estimate the fat and muscle volume changes in musculocutaneous flaps during long-term follow-up. METHODS:  We conducted a retrospective analysis of 35 patients after musculocutaneous flap reconstruction. The total, fat, and muscle volumes of the musculocutaneous flaps were measured using 3-dimensional images. Changes in flap volumes over time (1 month, 1 year [POY1], and 5 years [POY5] postoperatively) were assessed. Flap persistence was calculated using flap volumes at 1 month after reconstruction for reference. RESULTS:  Flap persistence at POY5 was 42.0% in total, 64.1% in fat, and 25.4% in muscle. Muscle persistence was significantly decreased (p < 0.0001). In a multiple regression analysis, decreased body mass index (BMI) of ≥ 5% influenced fat persistence less than muscle persistence at POY1; however, there was no significant difference at POY5. Postoperative radiation therapy was associated with a significant decrease in total flap persistence at POY1 (p = 0.046) and POY5 (p = 0.0097). Muscle persistence significantly decreased at POY5 (p = 0.0108). Age significantly influenced muscle volume at POY1 (p = 0.0072). CONCLUSION:  Reconstruction flaps are well-preserved with high fat-to-muscle ratios. Recommendations for weight maintenance are necessary for patients less than 2 years after surgery due to the influence of BMI on fat persistence. Radiation therapy is necessary for some patients based on their disease state. Intensity-modulated radiation therapy can be offered to reduce scattering irradiation to normal tissues.

  May 2019, Journal of reconstructive microsurgery, 35(4) (4), 235 - 243, English, International magazine

  [Refereed]

  Scientific journal


• Induced Pluripotent Stem Cell-related Genes Correlate With Poor Prognoses of Oral Squamous Cell Carcinoma.

  Yumi Muraki, Takumi Hasegawa, Daisuke Takeda, Takeshi Ueha, Eiji Iwata, Izumi Saito, Rika Amano, Akiko Sakakibara, Masaya Akashi, Takahide Komori

  BACKGROUND/AIM: We recently investigated the contribution of the iPS-related genes SOX2, OCT4, and Nanog to de-differentiation by assaying for their mRNA levels. Given that mRNA expression does not always correlate with the protein levels, the aim of this study was to retrospectively determine the expression of these four iPS-related factors in human OSCC specimens by immunohistochemistry and examine their association with patient prognosis. MATERIALS AND METHODS: iPS cell-related gene expression in 89 OSCC patients by tissue microarray, and its correlation with clinicopathological factors, differentiation, metastasis, and poor prognoses were investigated. RESULTS: No evidence of statistically significant relationships was found between the expression of iPS cell-related genes and clinicopathological parameters. However, our data indicated that KLF4 expression was associated with survival, and poor tumor differentiation. In addition, high expression of KLF4 was an independent poor prognostic factor (p=0.004) for OSCC patients. CONCLUSION: In preoperative biopsies, higher KLF4 and poor differentiation may be clinically effective predictors for the prognosis of oral cancer.

  Mar. 2019, Anticancer research, 39(3) (3), 1205 - 1216, English, International magazine

  [Refereed]

  Scientific journal


• Perioperative intervention by oral medicine team in cardiovascular surgery patients.

  Masaya Akashi, Nagisa Nanba, Junya Kusumoto, Takahide Komori

  In brief, perioperative oral intervention consists of elimination of odontogenic foci and maintenance of oral hygiene in patients undergoing surgery. The importance of oral intervention before, during, and after medical treatments is well-known, especially in cancer patients, because odontogenic foci such as untreated deep dental caries or periodontitis can cause systemic infection in patients with myelosuppression resulting from chemotherapy. Although perioperative oral intervention is currently recommended for patients with cardiovascular disease, its efficacy in this population has not been established. This article consists of three sections: first, we review the current knowledge about the association between dental disease and cardiovascular disease to show the importance of oral hygiene maintenance and the risks of invasive dental procedures in patients with cardiovascular disease; second, we introduce pertinent, but limited evidence concerning the effect of oral care in preventing postoperative pneumonia; and finally, we present the optimal strategy for perioperative oral intervention in cardiovascular surgery patients.

  Feb. 2019, General thoracic and cardiovascular surgery, 67(2) (2), 197 - 202, English, Domestic magazine

  [Refereed][Invited]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A literature review of perioperative antibiotic administration in surgery for medication-related osteonecrosis of the jaw.

  Masaya Akashi, Junya Kusumoto, Daisuke Takeda, Takashi Shigeta, Takumi Hasegawa, Takahide Komori

  PURPOSE: Few studies exist that focus on the details of perioperative antibiotic administration for surgery to treat medication-related osteonecrosis of the jaw (MRONJ). The regime and duration of perioperative antibiotics applied in published studies were reviewed to clarify appropriate perioperative antibiotic use in MRONJ surgery. METHODS: A literature search was conducted using the MEDLINE database via PubMed. RESULTS: The search resulted in 453 hits on PubMed. After reading the downloaded full-text articles, 17 articles met the inclusion and exclusion criteria. The most common perioperative antibiotic used for MRONJ surgery was a combination of penicillin-based antibiotics and β-lactamase inhibitor (52.9%), and the second most common regime was penicillin-based antibiotics with metronidazole (17.6%). The duration of administration was 2 weeks postoperatively in nine studies, whereas four studies applied long-term administration (2-6 weeks postoperatively). CONCLUSIONS: Oral and maxillofacial surgeons mostly prefer penicillin-based antibiotics plus β-lactamase inhibitor or metronidazole for MRONJ surgery. The duration of administration of these medications may be based on empirical experience.

  Dec. 2018, Oral and maxillofacial surgery, 22(4) (4), 369 - 378, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma.

  Satomi Arimoto, Takumi Hasegawa, Daisuke Takeda, Izumi Saito, Rika Amano, Masaya Akashi, Takahide Komori

  BACKGROUND/AIM: Tumor lymphangiogenesis plays a key role in lymph node (LN) metastasis in oral squamous cell carcinoma (OSCC). The purpose of this study was to investigate podoplanin and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) and their relationship to nodal metastasis and other clinicopathological variables. PATIENTS AND METHODS: Podoplanin and LYVE-1 expression of the primary tumor and normal tissue were investigated by means of a quantitative real-time PCR assay and immunohistochemistry in samples from 33 cases of OSCC. RESULTS: The mRNA high expression levels of both genes had a statistically significantly higher rate of LN metastasis (p<0.01) and histological grade (p<0.01 for podoplanin, p<0.05 for LYVE-1). High expression of each gene, as shown by immunohistochemistry, had a statistically significant higher rate of LN metastasis (p<0.01 for podoplanin, p<0.05 for LYVE-1). CONCLUSION: Podoplanin and LYVE-1 were strongly associated with LN metastasis.

  Nov. 2018, Anticancer research, 38(11) (11), 6157 - 6162, English, International magazine

  [Refereed]

  Scientific journal


• Gold nanoparticles enhance X-ray irradiation-induced apoptosis in head and neck squamous cell carcinoma in vitro.

  Shun Teraoka, Yasumasa Kakei, Masaya Akashi, Eiji Iwata, Takumi Hasegawa, Daisuke Miyawaki, Ryohei Sasaki, Takahide Komori

  Enhancing the antitumor effect of radiation, while reducing damage to organs, is a significant challenge in radiation therapy for head and neck malignancies. One promising radiosensitizer is gold. The present study aimed to determine whether gold nanoparticles (AuNPs) have the potential to enhance the effects of X-ray irradiation on head and neck cancer cells. The human head and neck carcinoma cell line HSC-3 was used. Total cell number and the levels of cell proliferation and apoptosis were compared between control cells and cells treated with 5-nm AuNPs alone at four concentrations (0.1, 0.4, 1.0 and 10.0 nM), X-ray irradiation alone at three doses (2, 4 and 8 Gy), or a combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs. Analysis of variance and Tukey-Kramer testing were performed to compare the different groups. The total number of cells significantly decreased following 4 and 8 Gy X-ray irradiation, compared with in the control group (control vs. 4Gy, P=2.19×10-4; control vs. 8Gy, P=1.28×10-6). The combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs significantly reduced the total number of cells compared with 4 Gy X-ray irradiation alone (P=2.95×10-4). Cell proliferation was not affected by AuNP treatment alone, 4 Gy X-ray irradiation alone or the combination of X-ray irradiation and AuNPs. The combination of 4 Gy irradiation and 1.0 nM AuNPs significantly increased the number of apoptotic cells compared with 4 Gy irradiation alone (P=0.0261). In conclusion, AuNPs combined with X-ray irradiation enhanced the cytotoxic effect on human head and neck cancer cells in vitro, through the induction of apoptosis, but not inhibition of cell proliferation.

  Corresponding, Nov. 2018, Biomedical reports, 9(5) (5), 415 - 420, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effect of local application of transcutaneous carbon dioxide on survival of random-pattern skin flaps.

  Izumi Saito, Takumi Hasegawa, Takeshi Ueha, Daisuke Takeda, Eiji Iwata, Satomi Arimoto, Akiko Sakakibara, Masaya Akashi, Shunsuke Sakakibara, Yoshitada Sakai, Hiroto Terashi, Takahide Komori

  INTRODUCTION: Skin flap procedures are widely used to reconstruct skin and soft tissue defects. Skin flap necrosis is a serious postoperative complication. Many researchers have introduced pharmacological agents to improve flap ischemia in experimental studies. However, outcomes of these studies remain controversial. We previously demonstrated that transcutaneous CO2 application improves hypoxia in fracture repair. In this study, we hypothesized that improving hypoxia by transcutaneous CO2 application can improve the blood flow in skin flaps and increase angiogenesis. We investigated whether transcutaneous CO2 application can increase the survival of random-pattern skin flaps. MATERIALS AND METHODS: Six-week-old male Sprague-Dawley rats were divided into two equal groups: the control group (n = 6) and CO2 group (n = 6). A random-pattern skin flap was constructed in these rats. Topical CO2 was applied using a hydrogel every day for 5 days in the CO2 group. The flap survival area was measured on postoperative days 1, 3, and 5. The vessel density and expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and hypoxia-inducible factor-1α (HIF-1α) were evaluated on postoperative day 5. RESULTS: A statistically significant difference was found in the percentage of the flap survival area between the two groups on postoperative days 3 and 5 (p < 0.05). Furthermore, the expression of VEGF and bFGF was significantly higher and that of HIF-1α was significantly lower in the CO2 than in the control group (p < 0.05). CONCLUSIONS: Transcutaneous CO2 application can improve the blood flow in skin flaps and increase angiogenesis, thus increasing the survival of random-pattern skin flaps.

  Nov. 2018, Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 71(11) (11), 1644 - 1651, English, International magazine

  [Refereed]

  Scientific journal


• Delayed Socket Healing After Dental Extraction in Patients Undergoing Myelosuppressive Chemotherapy for Hematological Malignancy: Incidence and Risk Factors.

  Masaya Akashi, Megumi Kishimoto, Junya Kusumoto, Kimikazu Yakushijin, Hiroshi Matsuoka, Takahide Komori

  PURPOSE: The purpose of this study was to measure the frequency and identify factors associated with delayed socket healing after dental extraction in patients undergoing myelosuppressive chemotherapy for hematologic malignancy. MATERIALS AND METHODS: This prospective cohort study focused on delayed healing after extraction in patients with hematologic malignancy. Sockets with delayed healing were defined as those with intense pain and bone exposure 1 week postoperatively. Patients with and without delayed socket healing were compared using the Fisher exact test and Mann-Whitney U test with some variables. Receiver operating characteristics curve analysis was conducted to define cutoff values for delayed healing. RESULTS: One hundred ninety-four dental extractions in 93 patients (median age, 64 yr; range, 20 to 85 yr) were analyzed. The incidence of delayed socket healing was 7.5% (7 of 93 patients). There was no postoperative bleeding. Older age, type of hematologic malignancy (acute leukemia), shorter time from dental extraction to initiation of chemotherapy, low platelet count or hemoglobin level, requirement for red blood cell concentrate or platelet transfusion, and use of an absorbable hemostatic agent were statistically associated with the occurrence of delayed socket healing. Platelet and hemoglobin cutoffs were 4.6 × 104/μL and 7.7 g/dL, respectively. CONCLUSIONS: Although dental extraction can be safely performed in patients undergoing myelosuppressive chemotherapy for hematologic malignancy, oral surgeons should understand the potential risk for delayed socket healing. When considering dental extraction, patients with hematologic malignancy and low hemoglobin or platelet levels should be informed about the possibility of delayed socket healing.

  Oct. 2018, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 76(10) (10), 2057 - 2065, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Association between pain severity and clinicohistopathologic findings in the mandibular canal and inferior alveolar nerve of patients with advanced mandibular osteoradionecrosis.

  Yujiro Hiraoka, Masaya Akashi, Satoshi Wanifuchi, Junya Kusumoto, Manabu Shigeoka, Takumi Hasegawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori

  Corresponding, Mosby Inc., Sep. 2018, Oral surgery, oral medicine, oral pathology and oral radiology, 126(3) (3), 264 - 271, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Ionizing Radiation Enhances Paracellular Permeability Through Alteration of Intercellular Junctions in Cultured Human Lymphatic Endothelial Cells.

  Megumi Kishimoto, Masaya Akashi, Yasumasa Kakei, Junya Kusumoto, Akiko Sakakibara, Takumi Hasegawa, Shungo Furudoi, Ryohei Sasaki, Takahide Komori

  BACKGROUND: A problematic complication after radiation therapy is lymphedema. Development of lymphedema is associated with an increase in lymphatic paracellular permeability. The current study investigated the effects of radiation on intercellular junctions and paracellular permeability in cultured human dermal lymphatic endothelial cells (HDLECs). METHODS AND RESULTS: Double immunofluorescence staining with vascular endothelial (VE)-cadherin and actin immediately after X-ray irradiation (5 or 20 Gy) was performed. Morphological changes induced by irradiation were assessed. Cell viability and paracellular permeability after irradiation were also evaluated. Broad junctions in which VE-cadherin was accumulated at cell-cell contacts and almost colocalized with actin were significantly decreased in a dose-dependent manner in confluent and sparse irradiated HDLECs. Irradiation shortened the width of VE-cadherin-positive areas at the cell-cell contacts. Actin filaments did not colocalize with VE-cadherin after 20 Gy irradiation. Although cell viability was not affected by irradiation, paracellular permeability significantly increased in a dose-dependent manner. CONCLUSIONS: A dose of 5 or 20 Gy irradiation in HDLECs does not affect cell viability, but changes VE-cadherin mediated intercellular junctions and actin structure, resulting in an increase of paracellular permeability. Further investigations on the regulatory proteins involved in radiation-induced changes, which were observed in the current study, may contribute to development of lymphedema therapy.

  Corresponding, Aug. 2018, Lymphatic research and biology, 16(4) (4), 390 - 396, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Treatment modalities and risk factors associated with refractory neurosensory disturbances of the inferior alveolar nerve following oral surgery: a multicentre retrospective study

  T. Hasegawa, S. I. Yamada, N. Ueda, S. Soutome, M. Funahara, M. Akashi, S. Furuno, H. Miyamoto, S. Hayashida, R. Amano, K. Mori, Y. Kojima, H. Kurita, T. Kirita, M. Umeda, Y. Shibuya, S. Fujita, T. Komori, Japanese Study Group of Cooperative Dentistry with Medicine (JCDM)

  Churchill Livingstone, Jun. 2018, International Journal of Oral and Maxillofacial Surgery, 47(6) (6), 794 - 801, English

  [Refereed]

  Scientific journal


• 血管柄付遊離皮弁を用いた口腔癌の術後感染に関わる因子の検討

  梶真人, Furudoi Shungo, 岸本恵美, 岩田英治, 高橋淳子, 楠元順哉, Akashi Masaya, Komori Takahide

  (一社)日本口腔感染症学会, Jun. 2018, 日本口腔感染症学会雑誌, 25(1) (1), 14 - 19, Japanese

  [Refereed]


• Elucidating the masticatory function and oral quality of life according to the range of mandibulectomy

  Michinori Maeda, Marina Hirose, Keinoshin Wada, Megumi Kishimoto, Masaya Akashi, Akira Kimoto, Takahide Komori, Yasuyuki Shibuya

  Elsevier Ltd, May 2018, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 30(3) (3), 220 - 224, English

  [Refereed]

  Scientific journal


• Computed Tomographic Evaluation of Posttreatment Soft-Tissue Changes by Using a Lymphedema Scoring System in Patients with Oral Cancer.

  Masaya Akashi, Shun Teraoka, Yasumasa Kakei, Junya Kusumoto, Takumi Hasegawa, Tsutomu Minamikawa, Kazunobu Hashikawa, Takahide Komori

  BACKGROUND: This study aimed to evaluate posttreatment soft-tissue changes in patients with oral cancer with computed tomography (CT). To accomplish that purpose, a scoring system was established, referring to the criteria of lower leg lymphedema (LE). METHODS AND RESULTS: One hundred and six necks in 95 patients who underwent oral oncologic surgery with neck dissection (ND) were analyzed retrospectively using routine follow-up CT images. A two-point scoring system to evaluate soft-tissue changes (so-called "LE score") was established as follows: Necks with a "honeycombing" appearance were assigned 1 point. Necks with "taller than wide" fat lobules were assigned 1 point. Necks with neither appearance were assigned 0 points. Comparisons between patients with LE score ≥1 and LE score = 0 at 6 months postoperatively were performed using the Fisher exact test for discrete variables and the Mann-Whitney U test for continuous variables. Univariate predictors associated with posttreatment changes (i.e., LE score ≥1 at 6 months postoperatively) were entered into a multivariate logistic regression analysis. Values of p < 0.05 were considered to indicate statistical significance. The occurrence of the posttreatment soft-tissue changes was 32%. Multivariate logistic regression analysis showed that postoperative radiation therapy (RT) and bilateral ND were potential risk factors of posttreatment soft-tissue changes on CT images. CONCLUSIONS: Sequential evaluation of "honeycombing" and the "taller than wide" appearances on routine follow-up CT revealed the persistence of posttreatment soft-tissue changes in patients who underwent oral cancer treatment, and those potential risk factors were postoperative RT and bilateral ND.

  Apr. 2018, Lymphatic research and biology, 16(2) (2), 147 - 153, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 下顎歯肉癌を生じたCowden症候群の1例

  榎本由依, AKASHI MASAYA, 平岡佑二郎, SHIGEOKA MANABU, MINAMIKAWA TSUTOMU, KOMORI TAKAHIDE

  (公社)日本口腔外科学会, Apr. 2018, 日本口腔外科学会誌, 64(4) (4), 213 - 218, Japanese

  [Refereed]


• Differences between osteoradionecrosis and medication-related osteonecrosis of the jaw.

  Masaya Akashi, Satoshi Wanifuchi, Eiji Iwata, Daisuke Takeda, Junya Kusumoto, Shungo Furudoi, Takahide Komori

  PURPOSE: The appearance of osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) is similar, but clinically important differences between ORN and MRONJ exist. The aim of this study was to compare the clinical data between ORN and MRONJ and to reveal the critical differences between these diseases. METHODS: We retrospectively reviewed the epidemiological data, clinical findings, and treatment in 27 ORN and 61 MRONJ patients. Radiographic signs before the initiation of treatment were also assessed. RESULTS: The median age (P = 0.0474) and the ratio of female to male patients (P < 0.0001) were significantly higher in MRONJ patients. There were significantly more MRONJ patients who reported a history of pain when compared with ORN patients (P = 0.0263). As an aetiological factor, tooth extraction was significantly more relevant to MRONJ than ORN (P = 0.0352). When assessing the radiographic signs on computed tomographic images, periosteal reaction was found only in MRONJ patients (P = 0.0158). Minimal debridement was performed significantly more frequently for MRONJ (P = 0.0093), and by contrast, surgical resection was performed more frequently for ORN (P = 0.0002). CONCLUSIONS: Understanding the clinical and underlying pathological differences between ORN and MRONJ probably contributes to the selection of appropriate treatment for each patient.

  Mar. 2018, Oral and maxillofacial surgery, 22(1) (1), 59 - 63, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• スニチニブ投与患者に発症した顎骨壊死の1例

  岩田英治, Furudoi Shungo, 鰐渕聡, 岸本恵実, Akashi Masaya, Komori Takahide

  (公社)日本口腔外科学会, Feb. 2018, 日本口腔外科学会雑誌, 64(2) (2), 83 - 87, Japanese

  [Refereed]


• Four-Dimensional Computed Tomography Evaluation of Condylar Movement in a Patient With Temporomandibular Joint Osteoarthritis.

  Masaya Akashi, Takumi Hasegawa, Satoru Takahashi, Takahide Komori

  W.B. Saunders, Feb. 2018, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 76(2) (2), 304 - 313, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Facial artery musculomucosal flap to close an oroantral fistula

  Yumi Ohtsuki, Masaya Akashi, Kazunobu Hashikawa, Takahide Komori

  Corresponding, Elsevier Ltd, 2018, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Potential role of post-treatment follow-up FDG-PET CT to detect mandibular osteoradionecrosis: A case report.

  Masaya Akashi, Satoshi Wanifuchi, Junya Kusumoto, Megumi Kishimoto, Yasumasa Kakei, Kazunobu Hashikawa, Takahide Komori

  It was hypothesized that fluorodeoxyglucose (FDG) uptake on post-treatment follow-up positron emission tomography with computed tomography (PET CT; using PET CT to monitor and rule out recurrence and metastasis of head and neck carcinoma) would be useful for detecting and understanding the disease state of osteoradionecrosis (ORN) of the jaw. The present study included 14 patients who developed mandibular ORN following radiation therapy (RT) for head and neck cancer and underwent follow-up PET CT several times following RT. Areas exhibiting FDG uptake were retrospectively assessed on post-treatment follow-up PET CT images and were classified into three types: Spot type: Only spot accumulation of FDG; localized type: Accumulation of FDG restricted to within the bone resorption area; extensive type: Accumulation of FDG extending into surrounding soft tissue. PET classification at the time of clinical diagnosis of mandibular ORN in the 14 patients demonstrated the extensive type in 43%, localized type in 36% and spot type in 21%. An increased area of FDG uptake around the ORN was revealed retrospectively on post-treatment follow-up FDG PET-CT images in 50% of patients. Alterations in PET classification included spot type to localized type in 36% and localized type to extensive type in 14%. A significantly increased number of patients with extensive-type ORN (P=0.026) required surgery. Post-treatment follow-up FDG-PET CT may be useful for early detection and better understanding of ORN.

  Jan. 2018, Molecular and clinical oncology, 8(1) (1), 61 - 67, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Case Series of Fibro-Osseous Lesions of the Jaws.

  Masaya Akashi, Kenji Matsuo, Manabu Shigeoka, Yasumasa Kakei, Takumi Hasegawa, Akira Tachibana, Shungo Furudoi, Takahide Komori

  The aim of this case series was to reveal the difficulties in diagnosing fibro-osseous lesions with radiological and histopathological examinations and quantify the potential risk of infection to fibro-osseous legions. To analyze the concordance between radiological and histopathological diagnoses, this retrospective case series included patients who were clinically diagnosed with fibro-osseous lesions via radiological findings and excluded the patients who did not undergo histopathological examinations. This study also included the patients in whom histopathological results confirmed fibro-osseous legions when preoperative radiological diagnosis did not include fibro-osseous legions. Eleven patients (three men, eight women; median age 24.5 years, range 15-57 years) were enrolled. Although radiological diagnoses of fibrous dysplasia (FD) corresponded with histopathological diagnoses in seven patients, mismatches between radiological findings and histopathological results were found in three patients. In one patient, suspected diagnosis with radiological examinations was malignant lymphoma or FD. In two patients, the histopathological differentiation between FD and ossifying fibroma (OF) was difficult. One patient had lesion recurrence which was suspected to be OF with surgical findings and postoperative course after the initial surgery. In three patients, infections of FD were found. Preoperative diagnosis of OF with radiographic feature of unilocular radiolucency is difficult. In cases in which histopathological differentiation between FD and OF is difficult, operative findings should be used because OF is often found to be well-encapsulated and easily enucleated. Bone in FD showing mixed radiolucent-radiopaque may be vulnerable to infection.

  Dec. 2017, The Kobe journal of medical sciences, 63(3) (3), E73-E79 - 79, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Dental injuries caused by endotracheal intubation – A retrospective study

  Yasumasa Kakei, Masaya Akashi, Masahiko Kashin, Sayaka Komori, Takahide Komori

  Elsevier Ltd, Nov. 2017, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 29(6) (6), 518 - 521, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Axial four-dimensional computed tomographic images to analyze crosswise differences in protrusive condylar movement in patients who underwent mandibulectomy and free flap reconstruction.

  Masaya Akashi, Toshinori Sekitani, Yumi Ohtsuki, Yasumasa Kakei, Junya Kusumoto, Takumi Hasegawa, Michinori Maeda, Noriyuki Negi, Kazunobu Hashikawa, Yasuyuki Shibuya, Satoru Takahashi, Takahide Komori

  Nov. 2017, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 45(11) (11), 1778 - 1783, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Literature Review of Criteria for Defining Recipient-Site Infection after Oral Oncologic Surgery with Simultaneous Reconstruction.

  Masaya Akashi, Junya Kusumoto, Akiko Sakakibara, Kazunobu Hashikawa, Shungo Furudoi, Takahide Komori

  Oct. 2017, Surgical infections, 18(7) (7), 755 - 764, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo.

  Tetsuya Hara, Tomoko Monguchi, Noriko Iwamoto, Masaya Akashi, Kenta Mori, Toshihiko Oshita, Mitsumasa Okano, Ryuji Toh, Yasuhiro Irino, Masakazu Shinohara, Yui Yamashita, Go Shioi, Mikio Furuse, Tatsuro Ishida, Ken-Ichi Hirata

  Sep. 2017, Arteriosclerosis, thrombosis, and vascular biology, 37(9) (9), 1667 - 1673, English, International magazine

  [Refereed]

  Scientific journal


• インプラント周囲に放射線性顎骨壊死を生じ保存的に治療した1例

  明石昌也, 鰐渕聡, 岩田英治, 筧康正, Hasegawa Takumi, 鈴木泰明, Komori Takahide

  (公社)日本顎顔面インプラント学会, Aug. 2017, Japanese Journal of Maxillo Facial Implants, 16(2) (2), 75 - 80, Japanese

  [Refereed]


• Changes in cell junctions induced by inhibition of epidermal growth factor receptor in oral squamous cell carcinoma cells.

  Yasumasa Kakei, Shun Teraoka, Masaya Akashi, Takumi Hasegawa, Takahide Komori

  Corresponding, Aug. 2017, Experimental and therapeutic medicine, 14(2) (2), 953 - 960, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 頭頸部癌患者における化学放射線療法による口腔粘膜炎の重症度を予測する因子

  岸本恵実, Furudoi Shungo, 岩田英治, 藤林淳子, 楠元順哉, 明石昌也, Komori Takahide

  (一社)日本口腔感染症学会, Jul. 2017, 日本口腔感染症学会雑誌, 24(1) (1), 9 - 13, Japanese

  [Refereed]


• Postoperative drainage in head and neck surgery for oral cancer

  Izumi Saito, Takumi Hasegawa, Eiji Iwata, Natsuki Yonezawa, Satomi Arimoto, Daisuke Takeda, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

  Elsevier Ltd, May 2017, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 29(3) (3), 217 - 221, English

  [Refereed]

  Scientific journal


• 肺癌術後肺合併症と周術期口腔機能管理の有用性

  岩田 英治, 長谷川 巧実, 西井 美佳, 明石 昌也, 古森 孝英

  (一社)日本口腔ケア学会, Apr. 2017, 日本口腔ケア学会雑誌, 11(3) (3), 170 - 170, Japanese

  [Refereed]


• Brain Abscess Potentially Resulting from Odontogenic Focus: Report of Three Cases and a Literature Review.

  Masaya Akashi, Kazuhiro Tanaka, Junya Kusumoto, Shungo Furudoi, Kohkichi Hosoda, Takahide Komori

  INTRODUCTION: Odontogenic foci can rarely cause intracranial infection. Hematogenous spread is considered to be the most important pathophysiological mechanism of intracranial infection of odontogenic origin. To investigate the oral origin of intracranial infections, oral surgeons should understand the underlying mechanisms by which oral bacteria spread to the central nervous system. However, there have been very few reports of intracranial infection resulting from odontogenic infection. CASE REPORTS: The authors report the cases of a 64-year-old man, a 68-year-old man, and a 64-year-old woman whose brain abscesses perhaps have arisen from odontogenic foci, because other sources of intracranial infection such as endocarditis and maxillary sinusitis were not found. Bacteriological examination of brain abscess specimens identified Staphylococcus aureus in case 1, Streptococcus constellatus, Fusobacterium nucleatum, and Parvimonas micra in case 2, and Lactobacillus catenaformis, Porphyromonas gingivalis, and F. nucleatum in case 3. All suspected causal teeth had no obvious signs of acute inflammation in all three cases. CONCLUSIONS: Oral surgeons should understand these characteristics of odontogenic brain abscess, in which the potentially causal odontogenic foci often lack acute symptoms. If other origins of infection are not found, it would be better to eliminate the potentially causal odontogenic foci for improvement of oral hygiene, however, the decision making criteria to eliminate suspected causal teeth is needed to be elucidated.

  Mar. 2017, Journal of maxillofacial and oral surgery, 16(1) (1), 58 - 64, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Meaning and Limitation of Cortical Bone Width Measurement with DentaScan in Medication-Related Osteonecrosis of the Jaws.

  Eiji Iwata, Masaya Akashi, Megumi Kishimoto, Junya Kusumoto, Takumi Hasegawa, Shungo Furudoi, Takahide Komori

  Corresponding, Kobe University School of Medicine, Feb. 2017, The Kobe journal of medical sciences, 62(5) (5), E114-E119 - E119, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Survival of Brånemark System Mk III implants and analysis of risk factors associated with implant failure

  T. Hasegawa, S. Kawabata, D. Takeda, E. Iwata, I. Saito, S. Arimoto, A. Kimoto, M. Akashi, H. Suzuki, T. Komori

  Churchill Livingstone, Feb. 2017, International Journal of Oral and Maxillofacial Surgery, 46(2) (2), 267 - 273, English

  [Refereed]

  Scientific journal


• Upregulated Expression of Transient Receptor Potential Cation Channel Subfamily V Receptors in Mucosae of Patients with Oral Squamous Cell Carcinoma and Patients with a History of Alcohol Consumption or Smoking.

  Akiko Sakakibara, Shunsuke Sakakibara, Junya Kusumoto, Daisuke Takeda, Takumi Hasegawa, Masaya Akashi, Tsutomu Minamikawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori

  2017, PloS one, 12(1) (1), e0169723, English, International magazine

  [Refereed]

  Scientific journal


• Prognosis of oral squamous cell carcinoma patients with level IV/V metastasis: An observational study.

  Takumi Hasegawa, Yasuyuki Shibuya, Daisuke Takeda, Eiji Iwata, Izumi Saito, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

  Jan. 2017, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 45(1) (1), 145 - 149, English, International magazine

  [Refereed]

  Scientific journal


• Intensity and duration of neutropenia relates to the development of oral mucositis but not odontogenic infection during chemotherapy for hematological malignancy.

  Megumi Kishimoto, Masaya Akashi, Kazuyuki Tsuji, Junya Kusumoto, Shungo Furudoi, Yasuyuki Shibuya, Yumiko Inui, Kimikazu Yakushijin, Shinichiro Kawamoto, Atsuo Okamura, Hiroshi Matsuoka, Takahide Komori

  Corresponding, 2017, PloS one, 12(7) (7), e0182021, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Heterogeneity of Necrotic Changes between Cortical and Cancellous Bone in Mandibular Osteoradionecrosis: A Histopathological Analysis of Resection Margin after Segmental Mandibulectomy.

  Masaya Akashi, Kazunobu Hashikawa, Satoshi Wanifuchi, Junya Kusumoto, Manabu Shigeoka, Shungo Furudoi, Hiroto Terashi, Takahide Komori

  2017, BioMed research international, 2017, 3125842 - 3125842, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Clinical Analysis of Tooth Injuries in Elderly Person

  古土井 春吾, 可信 雅彦, 筧 康正, 松本 耕祐, 明石 昌也, 古森 孝英

  日本外傷歯学会, Dec. 2016, 日本外傷歯学会雑誌, 12(1) (1), 53 - 59, Japanese


• Cause and occurrence timing of osteoradionecrosis of the jaw: a retrospective study focusing on prophylactic tooth extraction.

  Satoshi Wanifuchi, Masaya Akashi, Yasuo Ejima, Hirotaka Shinomiya, Tsutomu Minamikawa, Shungo Furudoi, Naoki Otsuki, Ryohei Sasaki, Ken-Ichi Nibu, Takahide Komori

  PURPOSE: This retrospective study aimed to analyze the relationship between tooth extraction and osteoradionecrosis (ORN) occurrence. The irradiation field, dose, and time interval between radiotherapy (RT) and ORN were reviewed. We also discuss appropriate guidelines for prophylactic tooth extraction. METHODS: A total of 33 patients treated for grade ≥2 (clinical) ORN in our department from 2002 to 2014 were enrolled. The following epidemiological data were retrospectively gathered: age, sex, histological diagnosis, primary tumor sites, radiation dose, chemotherapy, site of ORN, relationship between tooth extraction and ORN occurrence, and time interval between tooth extraction and the initiation or end of RT. RESULTS: Twenty-one percent of ORN cases resulted from tooth extraction. The most common site of ORN (82 %) was the mandibular molar region. About half of ORN cases (49 %) occurred within 2 years after RT. All patients who received tooth extraction after RT developed ORN (100 %) independently of time interval between tooth extraction and the end of RT (median interval, 37.5 months; range, 27-120 months). In contrast, only 50 % of patients who received tooth extraction before RT developed ORN. There may have been an association between the irradiation field and the site of ORN development CONCLUSIONS: ORN occurrence due to tooth extraction was 21 %. Occurrence timing of ORN did not depend on time interval between tooth extraction and the end of RT. The irradiation field is certainly related to the site of ORN; therefore, prophylactic tooth extraction should be performed in consideration of the proposed radiation field and dose.

  Corresponding, Dec. 2016, Oral and maxillofacial surgery, 20(4) (4), 337 - 342, English, International magazine

  [Refereed]

  Scientific journal


• Postradiotherapy Dental Implant Insertion Into Bone Grafts Harvested From Nonirradiated Tissue: Case Reports.

  Akira Kimoto, Yasuyuki Shibuya, Masaki Kobayashi, Masaya Akashi, Takumi Hasegawa, Hiroaki Suzuki, Takahide Komori

  Oct. 2016, Implant dentistry, 25(5) (5), 715 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Comparison between primary closure and skin grafts of the free fibula osteocutaneous flap donor site.

  Masaya Akashi, Kazunobu Hashikawa, Hiroyuki Takasu, Kazuhiro Watanabe, Junya Kusumoto, Akiko Sakakibara, Takumi Hasegawa, Tsutomu Minamikawa, Takahide Komori

  Springer Verlag, Sep. 2016, Oral and maxillofacial surgery, 20(3) (3), 233 - 7, English, International magazine

  [Refereed]

  Scientific journal


• Four-dimensional computed tomography evaluation of jaw movement following mandibular reconstruction: A pilot study.

  Masaya Akashi, Yasuyuki Shibuya, Satoru Takahashi, Kazunobu Hashikawa, Takumi Hasegawa, Yasumasa Kakei, Noriyuki Negi, Toshinori Sekitani, Takahide Komori

  May 2016, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 44(5) (5), 637 - 41, English, International magazine

  [Refereed]

  Scientific journal


• 対側オトガイ部の知覚異常が早期症状と疑われたびまん性大細胞型B細胞性リンパ腫の1例

  高端大希, 明石昌也, 高橋佑輔, 辻和志, 南川勉, Komori Takahide

  (公社)日本口腔外科学会, Apr. 2016, 日本口腔外科学会雑誌, 62(4) (4), 163 - 168, Japanese

  [Refereed]


• A comparison of radial forearm free-flap reconstruction and non-reconstruction after partial maxillectomy

  Akashi Masaya, ShibuyaY, TakahashiY, KusumotoJ, SakakibaraA, HasegawaT, MinamikawaT, HashikawaK, KomoriT

  2016, J Oral Maxillofac Surg Med Pathol, 28(2) (2), 111 - 117, English

  [Refereed]

  Scientific journal


• Incidence of Venous Thromboembolism After Oral Oncologic Surgery With Simultaneous Reconstruction.

  Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa, Tsutomu Minamikawa, Satoshi Usami, Takahide Komori

  Corresponding, Jan. 2016, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 74(1) (1), 212 - 7, English, International magazine

  [Refereed]

  Scientific journal


• Temporal Evaluation of Neurosensory Complications After Mandibular Third Molar Extraction: Current Problems for Diagnosis and Treatment.

  Masaya Akashi, Yujiro Hiraoka, Takumi Hasegawa, Takahide Komori

  Bentham Science Publishers B.V., 2016, The open dentistry journal, 10, 728 - 732, English, International magazine

  [Refereed]

  Scientific journal


• ロケーター・磁性バーアタッチメントによるインプラントオーバーデンチャー関連合併症

  有本智美, Hasegawa Takumi, 斉藤泉, 岩田英治, 武田大介, Akashi Masaya, Suzuki Yasuaki, 古土井春吾, Komori Takahide

  (公社)日本顎顔面インプラント学会, Nov. 2015, Japanese Journal of Maxillo Facial Implants, 14(3) (3), 261 - 261, Japanese


• 薬剤関連性顎骨壊死(MRONJ)の1例

  岩田英治, Akashi Masaya, 後藤育子, Furudoi Shungo, Komori Takahide

  (一社)日本口腔診断学会, Oct. 2015, 日本口腔診断学会雑誌, 28(3) (3), 208 - 212, Japanese

  [Refereed]


• 頭頸部領域における壊死性筋膜炎に対するLRINEC scoreの有用性の検討

  楠元順哉, Furudoi Shungo, 榊原晶子, 畑みどり, Akashi Masaya, Komori Takahide

  (公社)日本口腔外科学会, Oct. 2015, 日本口腔外科学会雑誌, 61(10) (10), 505 - 512, Japanese

  [Refereed]


• CT Evaluation of Morphology of Transferred Fibula for Implant Placement in Reconstructed Mandible

  Masaya Akashi, Yasuyuki Shibuya, Satoshi Wanifuchi, Junya Kusumoto, Akiko Sakakibara, Akira Kimoto, Takumi Hasegawa, Hiroaki Suzuki, Kazunobu Hashikawa, Takahide Komori

  Oct. 2015, IMPLANT DENTISTRY, 24(5) (5), 541 - 546, English

  [Refereed]

  Scientific journal


• Risk factors associated with postoperative delirium after surgery for oral cancer

  Takumi Hasegawa, Izumi Saito, Daisuke Takeda, Eiji Iwata, Natsuki Yonezawa, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

  Sep. 2015, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 43(7) (7), 1094 - 1098, English

  [Refereed]

  Scientific journal


• Sequential evaluation for bone union of transferred fibula flaps in reconstructed mandibles: panoramic X-ray versus computed tomography

  M. Akashi, K. Hashikawa, Y. Kakei, A. Sakakibara, T. Hasegawa, T. Minamikawa, T. Komori

  Corresponding, Aug. 2015, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(8) (8), 942 - 947, English

  [Refereed]

  Scientific journal


• Determining the location of the internal maxillary artery on ultrasonography and unenhanced magnetic resonance imaging before orthognathic surgery

  S. Arimoto, T. Hasegawa, N. Okamoto, A. Shioyasono, C. Tateishi, M. Akashi, H. Suzuki, S. Furudoi, T. Komori

  Aug. 2015, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(8) (8), 977 - 983, English

  [Refereed]

  Scientific journal


• Low-intensity pulsed ultrasound enhances bone morphogenetic protein expression of human mandibular fracture haematoma-derived cells

  W. Huang, T. Hasegawa, Y. Imai, D. Takeda, M. Akashi, T. Komori

  Jul. 2015, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(7) (7), 929 - 935, English

  [Refereed]

  Scientific journal


• 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価

  Akashi Masaya, 橋川和信, 榊原晶子, 楠元順哉

  (一社)日本形成外科学会, Jun. 2015, 日本形成外科学会会誌, 35(6) (6), 359 - 359, Japanese


• Risk Factors Associated with Distant Metastasis in Patients with Oral Squamous Cell Carcinoma

  Takumi Hasegawa, Makiko Tanakura, Daisuke Takeda, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

  Jun. 2015, OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 152(6) (6), 1053 - 1060, English

  [Refereed]

  Scientific journal


• Three-Dimensional Venous Visualization with Phase-Lag Computed Tomography Angiography for Reconstructive Microsurgery

  Shunsuke Sakakibara, Hiroyuki Onishi, Kazunobu Hashikawa, Masaya Akashi, Akiko Sakakibara, Tadashi Nomura, Hiroto Terashi

  May 2015, JOURNAL OF RECONSTRUCTIVE MICROSURGERY, 31(4) (4), 305 - 312, English

  [Refereed]

  Scientific journal


• Does Salivary Duct Repositioning Prevent Complications After Tumor Resection or Salivary Gland Surgery?

  Akiko Sakakibara, Tsutomu Minamikawa, Kazunobu Hashikawa, Shunsuke Sakakibara, Takumi Hasegawa, Masaya Akashi, Shungo Furudoi, Takahide Komori

  May 2015, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 73(5) (5), 1003 - 1007, English

  [Refereed]

  Scientific journal


• 頸部郭清術後に中毒性巨大結腸症を併発した偽膜性腸炎を発症した1例

  岩田英治, Furudoi Shungo, 楠元順哉, Akashi Masaya, 後藤育子, Komori Takahide

  (一社)日本口腔感染症学会, May 2015, 日本口腔感染症学会雑誌, 22(1) (1), 12 - 16, Japanese

  [Refereed]


• 当院における心臓血管外科患者に対する周術期口腔機能管理

  藤大補, Akashi Masaya, 古土井春吾, 西井美佳, 後藤育子, Komori Takahide

  (一社)日本口腔感染症学会, May 2015, 日本口腔感染症学会雑誌, 22(1) (1), 37 - 37, Japanese


• 抗RANKLモノクローナル抗体(デノスマブ)投与患者に発症した顎骨壊死の1例

  岩田英治, Akashi Masaya, Hasegawa Takumi, 古土井春吾, Komori Takahide

  (一社)日本口腔感染症学会, May 2015, 日本口腔感染症学会雑誌, 22(1) (1), 41 - 42, Japanese


• Postoperative abnormal response of C-reactive protein as an indicator for infectious complications after oral oncologic surgery with primary reconstruction

  Masaya Akashi, Shungo Furudoi, Kazunobu Hashikawa, Akiko Sakakibara, Takumi Hasegawa, Takashi Shigeta, Tsutomu Minamikawa, Takahide Komori

  Apr. 2015, JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 44, 13, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Retrospective study of changes in the sensitivity of the oral mucosa: sagittal split ramus osteotomy (SSRO) versus intraoral vertical ramus osteotomy (IVRO)

  T. Hasegawa, C. Tateishi, M. Asai, Y. Imai, N. Okamoto, A. Shioyasono, A. Kimoto, M. Akashi, H. Suzuki, S. Furudoi, T. Komori

  Mar. 2015, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(3) (3), 349 - 355, English

  [Refereed]

  Scientific journal


• 後方への進展なくルビエールリンパ節に転移を生じた口腔癌2例

  重田崇至, Minamikawa Tsutomu, Akashi Masaya, Hasegawa Takumi, 榊原晶子, 松井太輝, 筧康正, 高橋佑輔, 渋谷恭之, 梅田正博, Komori Takahide

  (一社)日本口腔腫瘍学会, Mar. 2015, 日本口腔腫瘍学会誌, 27(1) (1), 1 - 6, Japanese

  [Refereed]


• The osteogenic activity of human mandibular fracture haematoma-derived progenitor cells is affected by bisphosphonate in vitro

  Y. Imai, T. Hasegawa, D. Takeda, M. Akashi, T. Komori

  Mar. 2015, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(3) (3), 412 - 416, English

  [Refereed]

  Scientific journal


• Clinical Study of 19 Cases Resulting in Dental Implant Removal.

  Hiroaki Suzuki, Daiki Takahashi, Kenji Matsuo, Akira Kimoto, Kousuke Matsumoto, Takumi Hasegawa, Masaya Akashi, Takahide Komori

  Kobe University School of Medicine, Feb. 2015, The Kobe journal of medical sciences, 61(4) (4), E102-8 - E108, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Prospective Study of Dental Intervention for Hematopoietic Malignancy

  K. Tsuji, Y. Shibuya, M. Akashi, S. Furudoi, K. Yakushijin, S. Kawamoto, A. Okamura, H. Matsuoka, T. Komori

  Feb. 2015, JOURNAL OF DENTAL RESEARCH, 94(2) (2), 289 - 296, English

  Scientific journal


• Long-term Follow-up Study of Radial Forearm Free Flap Reconstruction After Hemiglossectomy

  Masaya Akashi, Kazunobu Hashikawa, Akiko Sakakibara, Takahide Komori, Hiroto Terashi

  Jan. 2015, JOURNAL OF CRANIOFACIAL SURGERY, 26(1) (1), 48 - 51, English

  [Refereed]

  Scientific journal


• Spindle cell carcinoma of the oral cavity: The impact of chemotherapy on pulmonary metastatic tumor doubling time

  Takashi Shigeta, Tsutomu Minamikawa, Taiki Matsui, Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa, Akiko Sakakibara, Yasuyuki Shibuya, Takahide Komori

  Kobe University School of Medicine, 2015, Kobe Journal of Medical Sciences, 61(3) (3), E64 - E70, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Measurement of the Total Number of Bacteria in Saliva Using Quantitative Real-Time PCR During Treatment for Head and Neck Malignancy: A Series of Cases

  GotoI, FurudoiS, Akashi Masaya, Komori Takahide

  2015, Oral Health Dent Manag, 142(776) (776), English

  [Refereed]

  Scientific journal


• Evaluation and comparison of CT values in bisphosphonate-related osteonecrosis of the jaw

  ImaiY, Hasegawa Takumi, TakedaD, KusumotoJ, Akashi Masaya, LeeSY, FurudoiS, Komori Takahide

  2015, J Oral Maxillofac Surg Med Pathol, English

  [Refereed]

  Scientific journal


• Alteration of Cell-Cell Junctions in Cultured Human Lymphatic Endothelial Cells with Inflammatory Cytokine Stimulation

  Yasumasa Kakei, Masaya Akashi, Takashi Shigeta, Takumi Hasegawa, Takahide Komori

  Corresponding, Sep. 2014, LYMPHATIC RESEARCH AND BIOLOGY, 12(3) (3), 136 - 143, English

  [Refereed]

  Scientific journal


• Sequential changes in oral dryness evaluated by a moisture-checking device in patients with oropharyngeal cancer during chemoradiotherapy: a pilot study

  Nishii M, Akashi Masaya, Kakei Y, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, Shibuya Yasuyuki, Takahashi M, Ohtsuki Naoki, Nibu Ken-ichi, Komori Takahide

  Corresponding, Jun. 2014, Oral Health Dent Manag, 13(2) (2), 507 - 11, English

  [Refereed]

  Scientific journal


• Oral squamous cell carcinoma with microscopic extracapsular spread in the cervical lymph nodes

  Y. Shibuya, Y. Ohtsuki, C. Hirai, T. Hasegawa, M. Akashi, T. Shigeta, T. Minamikawa, T. Komori

  Apr. 2014, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43(4) (4), 387 - 392, English

  [Refereed]

  Scientific journal


• The osteogenic activity of human mandibular fracture haematoma-derived cells is stimulated by low-intensity pulsed ultrasound in vitro

  Y. Imai, T. Hasegawa, D. Takeda, M. Akashi, S. Y. Lee, T. Niikura, Y. Shibuya, M. Kurosaka, T. Komori

  Mar. 2014, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43(3) (3), 367 - 372, English

  [Refereed]

  Scientific journal


• Changes in the sensitivity of cutaneous points and the oral mucosa after intraoral vertical ramus osteotomy

  T. Hasegawa, C. Tateishi, M. Asano, N. Takata, M. Akashi, T. Shigeta, S. Furudoi, Y. Shibuya, T. Komori

  Nov. 2013, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 42(11) (11), 1454 - 1461, English

  [Refereed]

  Scientific journal


• Preoperative MR angiography for free fibula osteocutaneous flap transfer

  Masaya Akashi, Tadashi Nomura, Shunsuke Sakakibara, Akiko Sakakibara, Kazunobu Hashikawa

  Sep. 2013, MICROSURGERY, 33(6) (6), 454 - 459, English

  [Refereed]

  Scientific journal


• Myelosuppression grading of chemotherapies for hematologic malignancies to facilitate communication between medical and dental staff: Lessons from two cases experienced odontogenic septicemia

  Masaya Akashi, Yasuyuki Shibuya, Junya Kusumoto, Shungo Furudoi, Yumiko Inui, Kimikazu Yakushijin, Atsuo Okamura, Hiroshi Matsuoka, Takahide Komori

  Aug. 2013, BMC Oral Health, 13(1) (1), 41, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Risk factors associated with inferior alveolar nerve injury after extraction of the mandibular third molar-a comparative study of preoperative images by panoramic radiography and computed tomography

  T. Hasegawa, S. Ri, T. Shigeta, M. Akashi, Y. Imai, Y. Kakei, Y. Shibuya, T. Komori

  Jul. 2013, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 42(7) (7), 843 - 851, English

  [Refereed]

  Scientific journal


• がん切除後下顎骨再建における再建理論「CATコンセプト」 臨床症例における実践結果

  Hashikawa Kazunobu, Akashi Masaya, 野村 正, 寺師 浩人

  (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2) (2), 166 - 166, Japanese

  [Refereed]


• Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice

  Tomoko Sugawara, Noriko Iwamoto, Masaya Akashi, Taro Kojima, Junzo Hisatsune, Motoyuki Sugai, Mikio Furuse

  Apr. 2013, JOURNAL OF DERMATOLOGICAL SCIENCE, 70(1) (1), 12 - 18, English

  [Refereed]

  Scientific journal


• Oral Squamous Cell Carcinoma With Multiple Neck Metastases-Cases With More Than Ten Pathologically Positive Lymph Nodes in the Unilateral Side

  Yasuyuki Shibuya, Takumi Hasegawa, Masaya Akashi, Takashi Shigeta, Tsutomu Minamikawa, Takahide Komori

  Apr. 2013, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 71(4) (4), 793 - 797, English

  [Refereed]

  Scientific journal


• p16 overexpression in malignant and premalignant lesions of the oral and esophageal mucosa following allogeneic hematopoietic stem cell transplantation

  Yasumasa Kakei, Masaya Akashi, Hideki Komatsubara, Tsutomu Minamikawa, Takahide Komori

  Corresponding, Jun. 2012, HEAD & NECK ONCOLOGY, 4, 38, English

  [Refereed]

  Scientific journal


• A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions

  Masaya Akashi, Tomohito Higashi, Sayuri Masuda, Takahide Komori, Mikio Furuse

  Lead, Sep. 2011, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 413(2) (2), 224 - 229, English

  Scientific journal


• Phosphorylation state regulates the localization of Scribble at adherens junctions and its association with E-cadherin-catenin complexes

  Ken Yoshihara, Junichi Ikenouchi, Yasushi Izumi, Masaya Akashi, Shoichiro Tsukita, Mikio Furuse

  Feb. 2011, EXPERIMENTAL CELL RESEARCH, 317(4) (4), 413 - 422, English

  [Refereed]

  Scientific journal


• LSR defines cell corners for tricellular tight junction formation in epithelial cells

  Sayuri Masuda, Yukako Oda, Hiroyuki Sasaki, Junichi Ikenouchi, Tomohito Higashi, Masaya Akashi, Eiichiro Nishi, Mikio Furuse

  Feb. 2011, JOURNAL OF CELL SCIENCE, 124(4) (4), 548 - 555, English

  [Refereed]

  Scientific journal


• 上顎洞内異物が自然排出された1例

  Akashi Masaya, 李 進彰, 石田 佳毅, 中川 直美, 柳川 由美恵, 古森 孝英

  (公社)日本口腔外科学会, Mar. 2008, 日本口腔外科学会雑誌, 54(3) (3), 210 - 213, Japanese

  [Refereed]


• A clinical study of temporomandibular joint disorders -An analysis based on the Japanese subtype classification

  Yasuyuki Shibuya, Junichiro Takeuchi, Noriko Ikehata, Masaya Akashi, Tsuyoshi Fujita, Satoshi Yokoo, Masahiro Umeda, Takahide Komori

  2007, Kobe Journal of Medical Sciences, 53(2) (2), 63 - 70, English

  [Refereed]

  Scientific journal


• 上顎洞内異物が自然排出した1例

  Akashi Masaya, 李 進彰, 石田 佳毅, 中川 直美, 柳川 由美恵, 古森 孝英

  (NPO)日本口腔科学会, Jan. 2007, 日本口腔科学会雑誌, 56(1) (1), 189 - 190, Japanese


• 輸血拒否患者(エホバの証人)に対する口腔癌手術の経験

  UMEDA, Masahiro, 李進彰, 石田佳毅, 中川直美, 明石昌也, 大川修司, 西松成器, MINAMIKAWA,Tsutomu, KOMORI, Takahide

  (一社)日本口腔腫瘍学会, Mar. 2006, 日本口腔腫瘍学会誌, 18(1) (1), 1 - 5, Japanese

  [Refereed]

• 頭頸部腺様嚢胞癌に対する陽子線治療の初期成績

  瓜生 開人, 出水 祐介, 岩下 和真, 福光 延吉, 明石 昌也, 副島 俊典

  (一社)日本頭頸部癌学会, May 2024, 頭頸部癌, 50(2) (2), 190 - 190, Japanese


• Neutrophil-to-lymphocyte ratio in response to nivolumab for oral squamous cell carcinoma: a retrospective cohort study

  立浪秀剛, 冨原圭, 山田慎一, 池田篤司, 今上修一, 中井裕美, 黒原一人, 吉岡幸男, 長谷川巧実, 鳴瀬智史, 新山宗, 嶋根哲, 上田倫弘, 柳本惣市, 明石昌也, 梅田正博, 栗田浩, 宮崎晃亘, 新井直也, 野口誠

  2023, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 41st


• Oral and maxillofacial exfoliative cytology based on LBC/Oral Bethesda system: Roles of cytology at hospital dentistry.

  佐々木亜紀, 重岡学, 重岡学, 米田亜紀子, 米田亜紀子, 武田大介, 明石昌也

  2023, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 41st


• 頭頸部粘膜悪性黒色腫に対する陽子線治療+adjuvant Nivolumab療法

  瓜生開人, 出水祐介, 窪田光, 美馬正幸, 福光延吉, 今村善宣, 明石昌也, 副島俊典

  2023, 頭頸部癌, 49(2) (2)


• 嗅神経芽細胞腫に対する陽子線を用いた術後照射 神戸陽子線センターにおける初期治療成績

  瓜生 開人, 出水 祐介, 美馬 正幸, 福光 延吉, 明石 昌也, 副島 俊典

  (一社)日本頭頸部癌学会, May 2022, 頭頸部癌, 48(2) (2), 239 - 239, Japanese


• A study of patients who needed to apply for nursing insurance during hospitalization for oral cancer

  武田大介, 長谷川巧実, 筧康正, 明石昌也

  2022, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 40th


• A multicenter retrospective study of tongue cancer closed surgical margins-Japan Oral Oncology Group (JOOG) study-

  大鶴光信, 長谷川巧実, 明石昌也, 山川延宏, 桐田忠昭, 大倉正也, 大倉正也, 山田慎一, 栗田浩, 平井英治, 山本晃三, 猪俣徹, 里見貴史, 齋藤寛一, 野村武史, 古川浩平, 鳴瀬智史, 柳本惣市, 梅田正博

  2022, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 40th


• Tongue Osseous Choristoma in an 11-Year-Old Female: A Case Report and Literature Review Focusing on Pediatric Cases

  Satomi Arimoto, Manabu Shigeoka, Masaya Akashi

  Hindawi Limited, 2021, Case Reports in Dentistry, 2021, English

  Book review


• Effect of percutaneous administration of carbon dioxide to improve tumor immunosuppression

  八谷奈苗, 長谷川巧実, 武田大介, 齊藤泉, 有本智美, 筧康正, 榊原晶子, 明石昌也

  2021, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 39th


• A case of tongue cancer histopathologically diagnosed as lymphoepithelial carcinoma

  武田大介, 重岡学, 長谷川真子, 村上明希, 八谷奈苗, 長谷川巧実, 明石昌也

  2021, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 39th


• Consideration of non-survival cases in patients with oral squamous cell carcinoma and Future perspectives in a tertiary referral center

  長谷川巧実, 武田大介, 筧康正, 明石昌也

  2021, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 39th


• 消化器外科SSI対策 経験からその検証へ 大腸癌術後SSIに対する周術期口腔ケアの予防効果に関する多施設共同研究

  延原 浩, 五月女 さき子, 林田 咲, 梅田 正博, 長谷川 巧実, 明石 昌也, 山田 慎一, 栗田 浩, 中原 寛和, 上田 順宏, 桐田 忠昭, 中村 知寿, 渋谷 恭之, 山口 泰平, 森 和代

  (一社)日本外科感染症学会, Oct. 2020, 日本外科感染症学会雑誌, 17(5) (5), 329 - 329, Japanese


• 舌下神経麻痺を契機に発見された前立腺癌脳転移の1例

  佐々木 亜紀, 木本 明, 八谷 奈苗, 村上 明希, 明石 昌也

  (NPO)日本口腔科学会, Sep. 2020, 日本口腔科学会雑誌, 69(3) (3), 245 - 245, Japanese


• 舌に生じた腺扁平上皮癌の1例

  大堀 浩明, 筧 康正, 山下 淳也, 南川 勉, 明石 昌也

  (NPO)日本口腔科学会, Sep. 2020, 日本口腔科学会雑誌, 69(3) (3), 248 - 248, Japanese


• 顎骨壊死の病態機序解明

  明石 昌也

  (株)北隆館, Jul. 2020, BIO Clinica, 35(7) (7), 680 - 683, Japanese


• 頭頸部癌における免疫チェックポイント阻害薬後の救済化学療法についての後方視的検討

  小山 泰司, 清田 尚臣, 今村 善宣, 長谷 善明, 高倉 嗣丈, 蓼原 瞬, 入谷 啓介, 古川 竜也, 手島 直則, 四宮 弘隆, 宮脇 大輔, 明石 昌也, 佐々木 良平, 丹生 健一

  (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 174 - 174, Japanese


• 当院における頭頸部がんに対する高用量シスプラチン併用化学放射線療法による急性腎障害の後方視的検討

  高倉 嗣丈, 今村 善宣, 小山 泰司, 長谷 善明, 四宮 弘隆, 手島 直則, 古川 竜也, 入谷 啓介, 蓼原 瞬, 宮脇 大輔, 明石 昌也, 佐々木 良平, 丹生 健一, 清田 尚臣

  (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 185 - 185, Japanese


• 嚢胞壁の一部に異所性胃粘膜を認めた甲状舌管嚢胞の1例

  小林 正樹, 森田 麻希, 中村 健人, 中村 知寿, 水谷 友美, 菱田 純代, 青木 尚史, 加藤 伸一郎, 明石 昌也, 渋谷 恭之

  (NPO)日本口腔科学会, Jul. 2020, 日本口腔科学会雑誌, 69(2) (2), 87 - 87, Japanese


• 原因検索に難渋した口底蜂窩織炎の1例

  岩田 英治, 橘 進彰, 格谷 僚, 高井 美玲, 榎本 由依, 楠元 順哉, 高田 直樹, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2020, 日本口腔科学会雑誌, 69(2) (2), 119 - 120, Japanese


• 顎骨壊死を契機として切開排膿を要した咀嚼筋隙膿瘍の検討

  下間 祐輝, 武田 大介, 佐々木 亜紀, 小林 英里奈, 八橋 明子, 齋藤 泉, 楠元 順哉, 長谷川 巧実, 古土井 春吾, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2020, 日本口腔科学会雑誌, 69(2) (2), 121 - 121, Japanese


• 当科で歯科介入を行った高用量骨吸収抑制薬使用患者におけるMRONJ発症とリスク因子についての検討

  廣田 純也, 長谷川 巧実, 武田 大介, 筧 康正, 楠元 順哉, 榊原 晶子, 木本 明, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2020, 日本口腔科学会雑誌, 69(2) (2), 153 - 153, Japanese


• 神戸大学医学部付属病院歯科口腔外科における抗菌薬適正使用の現状

  吉位 亮助, 楠元 順哉, 松村 恵美, 古土井 春吾, 明石 昌也

  (一社)日本口腔感染症学会, Jul. 2020, 日本口腔感染症学会雑誌, 27(1) (1), 36 - 37, Japanese


• エピシル口腔用液による口腔粘膜炎の疼痛緩和についての検討

  松村 恵実, 西井 美佳, 楠元 順哉, 古土井 春吾, 明石 昌也

  (一社)日本口腔感染症学会, Jul. 2020, 日本口腔感染症学会雑誌, 27(1) (1), 38 - 38, Japanese


• 若年女性の頬部蜂窩織炎から肺化膿症にまで進展したMRSA菌血症の1例

  大橋 雄高, 南川 勉, 岩田 英治, 松村 恵美, 古土井 春吾, 明石 昌也

  (一社)日本口腔感染症学会, Jul. 2020, 日本口腔感染症学会雑誌, 27(1) (1), 41 - 41, Japanese


• 頬部の皮膚充填剤により生じた頬部蜂窩織炎の1例

  榎本 由依, 橘 進彰, 岩田 英治, 高田 直樹, 明石 昌也

  (一社)日本口腔感染症学会, Jul. 2020, 日本口腔感染症学会雑誌, 27(1) (1), 44 - 44, Japanese


• 症状の背景にあるもの

  明石 昌也

  (一社)兵庫県歯科医師会, Jun. 2020, 歯界月報, (827) (827), 24 - 30, Japanese


• 口腔癌に対するレーザー照射とその影響

  佐々木 崇良, 木本 明, 八谷 奈苗, 山下 淳也, 重岡 学, 明石 昌也

  (一社)日本レーザー歯学会, May 2020, 日本レーザー歯学会誌, 30(1) (1), 22 - 22, Japanese


• アルツハイマー型認知症患者の口腔内に生じた孤立性形質細胞腫に対して放射線治療が奏功した1例

  棚倉万紀子, 武田大介, 三谷泉, 明石昌也

  2020, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 38th


• 口腔外科手術周術期における抗血栓療法患者に対するヘパリンブリッジの有効性に関する多施設共同後ろ向き観察研究

  後藤弘一, 山田慎一, 長谷川巧実, 吉村仁志, 五月女さき子, 冨原圭, 長谷川温, 菱田純代, 上田順宏, 傳田祐也, 岡本健二郎, 明石昌也, 近津大地, 野口誠, 太田嘉英, 藤田茂之, 藤田茂之, 渋谷恭之, 桐田忠昭, 梅田正博, 栗田浩

  2020, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 38th


• Effect of perioperative oral management on the prevention of surgical site infection after colorectal cancer surgery: A multicenter retrospective analysis

  延原浩, 五月女さき子, 林田咲, 梅田正博, 長谷川巧実, 明石昌也, 山田慎一, 栗田浩, 中原寛和, 上田順宏, 桐田忠昭, 中村知寿, 渋谷恭之, 山口泰平, 森和代

  2020, 日本外科感染症学会雑誌(Web), 17(5) (5)


• 【「顎骨再建材料」】ポリ-L-乳酸

  明石 昌也

  (一社)日本歯科理工学会, Jan. 2020, 日本歯科理工学会誌, 39(1) (1), 13 - 16, Japanese


• 明日から役立つ!がん患者の口腔機能管理テクニック

  西井 美佳, 古土井 春吾, 松村 恵実, 楠元 順哉, 明石 昌也

  (一社)日本口腔感染症学会, Jan. 2020, 日本口腔感染症学会雑誌, 26(2) (2), 68 - 73, Japanese


• 舌に発生した粘液脂肪腫の1例

  岩田 英治, 橘 進彰, 高井 美玲, 榎本 由依, 楠元 順哉, 高田 直樹, 明石 昌也

  (一社)日本口腔腫瘍学会, Dec. 2019, 日本口腔腫瘍学会誌, 31(4) (4), 203 - 206, Japanese


• 重症心身障がい児(者)における口腔衛生状態の実態調査

  柴田 里紗, 明石 昌也, 小紫 香代, 玉村 宣尚

  国立病院総合医学会, Nov. 2019, 国立病院総合医学会講演抄録集, 73回, P1 - 805, Japanese


• 【「歯科用レーザーの現在」】軟組織に対する歯科用レーザーの活用

  木本 明, 明石 昌也, 古森 孝英

  (一社)日本歯科理工学会, Sep. 2019, 日本歯科理工学会誌, 38(3) (3), 149 - 152, Japanese


• 歯科、口腔外科領域における進歩と課題 口腔がんに対するレーザー治療の応用 早期表在性舌がんに対するレーザー治療

  木本 明, 明石 昌也

  (NPO)日本レーザー医学会, Sep. 2019, 日本レーザー医学会誌, 40(3) (3), 265 - 265, Japanese


• 多剤耐性菌が検出された薬剤関連顎骨壊死患者の治療経験

  大橋 雄高, 古土井 春吾, 岸本 恵, 岩田 英治, 高橋 淳子, 楠元 順哉, 明石 昌也, 古森 孝英

  (一社)日本口腔感染症学会, Jun. 2019, 日本口腔感染症学会雑誌, 26(1) (1), 43 - 43, Japanese


• ゾレドロン酸の投与が奏効したび漫性硬化性下顎骨骨髄炎の1例

  佐藤 匠, 古土井 春吾, 大橋 雄高, 岸本 恵美, 岩田 英治, 楠元 順哉, 明石 昌也, 古森 孝英

  (一社)日本口腔感染症学会, Jun. 2019, 日本口腔感染症学会雑誌, 26(1) (1), 45 - 46, Japanese


• 頭頸部癌に対する放射線治療後の放射線性顎骨壊死に関する検討

  窪田 光, 宮脇 大輔, 佐々木 香織, 妹尾 悟史, 井上 由子, 川口 弘毅, 西川 遼, 石原 武明, 吉田 賢史, 岸本 恵美, 明石 昌也, 佐々木 良平

  (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 244 - 244, Japanese


• 頭頸部癌に対する放射線治療後の放射線性顎骨壊死に関する検討

  窪田 光, 宮脇 大輔, 佐々木 香織, 妹尾 悟史, 井上 由子, 川口 弘毅, 西川 遼, 石原 武明, 吉田 賢史, 岸本 恵美, 明石 昌也, 佐々木 良平

  (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 244 - 244, Japanese


• 口腔扁平上皮癌における人工多能性幹細胞関連因子の発現について

  武田大介, 長谷川巧実, 江崎友美, 榊原晶子, 明石昌也, 南川勉, 古森孝英

  2019, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th


• 当科におけるUnusualな再発症例について

  筧康正, 南川勉, 松田彩, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2019, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 122, Japanese


• 炭酸ガスを使用した効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果

  長谷川巧実, 武田大介, 齋藤泉, 岩田英治, 筧康正, 榊原晶子, 明石昌也, 南川勉, 古森孝英

  2019, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 120, Japanese


• 再建を伴う口腔癌の周術期静脈血栓塞栓症について

  筧康正, 明石昌也, 長谷川巧実, 南川勉, 古森孝英

  2019, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 112, Japanese


• 口腔癌におけるPET‐MRI~第二報~

  瓜生開人, 南川勉, 大橋雄高, 大橋雄高, 松田彩, 武田大介, 筧康正, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2019, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 156, Japanese


• 薬剤関連顎骨壊死の転帰に影響する因子についての検討

  古土井 春吾, 岩田 英治, 岸本 恵美, 高橋 淳子, 楠元 順哉, 明石 昌也, 古森 孝英

  (一社)日本口腔感染症学会, Dec. 2018, 日本口腔感染症学会雑誌, 25(2) (2), 71 - 77, Japanese


• 当科におけるインプラント埋入症例と喪失リスク因子に関する後ろ向き観察研究

  長谷川 巧実, 武田 大介, 齋藤 泉, 有本 智美, 筧 康正, 明石 昌也, 鈴木 泰明, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2018, Japanese Journal of Maxillo Facial Implants, 17(3) (3), 224 - 224, Japanese


• 当科におけるインプラント埋入症例と喪失リスク因子に関する後ろ向き観察研究

  長谷川巧実, 武田大介, 齋藤泉, 有本智美, 筧康正, 明石昌也, 鈴木泰明, 古森孝英

  (公社)日本顎顔面インプラント学会, Nov. 2018, Japanese Journal of Maxillo Facial Implants, 17(3) (3), 224 - 224, Japanese


• Four‐dimensional CT(4DCT)による咀嚼時の下顎頭前方滑走の解析

  関谷俊範, 明石昌也, 筧康正, 根宜典行, 西尾卓郎, 星野貴志, 櫻井玲, 泉谷信行, 日下亜起子, 古森孝英, 村上卓道

  (公社)日本診療放射線技師会, Sep. 2018, 日本診療放射線技師会誌, 65(9) (9), 1011 - 1011, Japanese


• 人工呼吸器装着中の重症心身障害児者における口腔環境と肺炎の関係

  柴田 里紗, 明石 昌也, 玉村 宜尚

  日本重症心身障害学会, Aug. 2018, 日本重症心身障害学会誌, 43(2) (2), 343 - 343, Japanese


• 当院における過去10年間の外傷歯症例の臨床的検討―世代別の特徴に関する分析―

  佐藤匠, 古土井春吾, 可信雅彦, 筧康正, 明石昌也, 古森孝英

  (一社)日本外傷歯学会, Jul. 2018, 日本外傷歯学会総会・学術大会プログラム・抄録集, 18回, 48 - 48, Japanese


• 頸部リンパ節転移陽性口腔扁平上皮癌の予後因子におけるlymph node ratioの有用性に関する検討

  筧 康正, 南川 勉, 白井 達也, 大橋 雄高, 松田 彩, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 103 - 103, Japanese


• 頸部郭清を伴う口腔癌術後合併症に関する臨床的検討

  八谷 奈苗, 長谷川 巧実, 武田 大介, 筧 康正, 松井 太輝, 明石 昌也, 南川 勉, 古土井 春吾, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 117 - 117, Japanese


• 膠原病を有する口腔癌症例の臨床的検討

  廣田 純也, 南川 勉, 松田 彩, 松井 太輝, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 121 - 121, Japanese


• 当科における口腔癌への緩和照射に関する臨床的検討

  松田 彩, 南川 勉, 白井 達也, 筧 康正, 松井 太輝, 長谷川 巧実, 榊原 晶子, 明石 昌也, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 112 - 112, Japanese


• 術後に気道閉塞を生じた口腔癌患者の3例

  香西 慎一, 松井 太輝, 筧 康正, 松田 彩, 明石 昌也, 長谷川 巧実, 南川 勉, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 113 - 113, Japanese


• 口腔癌術後に予定外に再度の全身麻酔による手術を要した症例の検討

  大橋 雄高, 筧 康正, 松田 彩, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 南川 勉, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 110 - 110, Japanese


• 口腔癌原発巣手術における術中迅速診断の臨床的検討

  白井 達也, 松井 太輝, 筧 康正, 大橋 雄高, 松田 彩, 長谷川 巧実, 明石 昌也, 南川 勉, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 119 - 119, Japanese


• 当科における過去10年間の血液培養検査に関する臨床的検討

  大橋 雄高, 古土井 春吾, 岸本 恵, 岩田 英治, 高橋 淳子, 楠元 順哉, 明石 昌也, 古森 孝英

  (一社)日本口腔感染症学会, Jun. 2018, 日本口腔感染症学会雑誌, 25(1) (1), 48 - 48, Japanese


• 翼突下顎隙に及ぶ蜂窩織炎に付随した舌神経知覚鈍麻に対し星状神経節ブロックを施行した1例

  白井 達也, 明石 昌也, 岸本 恵実, 古森 孝英

  (NPO)日本口腔科学会, Mar. 2018, 日本口腔科学会雑誌, 67(1) (1), 64 - 64, Japanese


• 下顎智歯抜歯後の術後出血に関するリスク因子についての検討

  廣田純也, 長谷川巧実, 西條翔, 大山剛平, 武田大介, 明石昌也, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2)


• 頸部郭清を伴う口腔癌術後合併症に関する臨床的検討

  八谷奈苗, 長谷川巧実, 武田大介, 筧康正, 松井太輝, 明石昌也, 南川勉, 古土井春吾, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2), 117(J‐STAGE), Japanese


• 頸部リンパ節転移陽性口腔扁平上皮癌の予後因子におけるlymph node ratioの有用性に関する検討

  筧康正, 南川勉, 白井達也, 大橋雄高, 大橋雄高, 松田彩, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2), 103(J‐STAGE), Japanese


• 膠原病を有する口腔癌症例の臨床的検討

  廣田純也, 南川勉, 松田彩, 松井太輝, 筧康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2), 121(J‐STAGE), Japanese


• 放射線性下顎骨壊死の診断におけるfollow up PET‐CTの有用性

  鰐渕聡, 明石昌也, 平岡佑二郎, 武田大介, 筧康正, 松井太輝, 長谷川巧実, 南川勉, 古土井春吾, 古森孝英

  2018, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 161, Japanese


• 皮弁再建後の再発舌癌に対して救済手術を施行した2例

  大橋雄高, 松井太輝, 筧康正, 正井友里子, 松田彩, 榊原晶子, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

  2018, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 181, Japanese


• 当科における口腔癌への緩和照射に関する臨床的検討

  松田彩, 南川勉, 白井達也, 筧康正, 松井太輝, 長谷川巧実, 榊原晶子, 明石昌也, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2), 112(J‐STAGE), Japanese


• 超音波断層法による口腔癌頸部リンパ節転移の検討

  筧康正, 南川勉, 正井友里子, 松田彩, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 重田崇至, 古森孝英

  2018, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 160, Japanese


• 舌扁平上皮癌の原発巣再発例の検討

  松井太輝, 南川勉, 大橋雄高, 正井友里子, 松田彩, 筧康正, 長谷川巧実, 明石昌也, 古森孝英

  2018, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 164, Japanese


• 術後に気道閉塞を生じた口腔癌患者の3例

  香西慎一, 松井太輝, 筧康正, 松田彩, 明石昌也, 長谷川巧実, 南川勉, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2), 113(J‐STAGE), Japanese


• 口腔癌術後病理minor risk症例の臨床的検討

  松田彩, 松井太輝, 正井友里子, 筧康正, 長谷川巧実, 榊原晶子, 明石昌也, 南川勉, 古森孝英

  2018, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 151, Japanese


• 口腔癌術後に予定外に再度の全身麻酔による手術を要した症例の検討

  大橋雄高, 筧康正, 松田彩, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2), 110(J‐STAGE), Japanese


• 口腔癌再建術後Recipient‐site infectionの定義に関する文献レビュー

  明石昌也, 筧康正, 武田大介, 松井太輝, 榊原晶子, 長谷川巧実, 南川勉, 橋川和信, 古森孝英

  2018, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 149, Japanese


• 口腔癌原発巣手術における術中迅速診断の臨床的検討

  白井達也, 松井太輝, 筧康正, 大橋雄高, 大橋雄高, 松田彩, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2), 119(J‐STAGE), Japanese


• 上顎部分切除後の顎義歯装着に関する皮弁再建・非再建群の比較

  可信雅彦, 筧康正, 明石昌也, 古森孝英

  (一社)日本顎顔面補綴学会, Dec. 2017, 顎顔面補綴, 40(2) (2), 55 - 55, Japanese


• 移植腓骨へ埋入したインプラント体の周囲炎に対し炭酸ガスレーザーを適用した1例

  山下淳也, 鈴木泰明, 筧康正, 木本明, 長谷川巧実, 明石昌也, 松本耕佑, 古森孝英

  (公社)日本顎顔面インプラント学会, Nov. 2017, Japanese Journal of Maxillo Facial Implants, 16(3) (3), 233 - 233, Japanese


• CBCTを用いた実物大臓器立体モデル作製の基礎検討

  西尾卓郎, 西尾卓郎, 山本慶彦, 福富朗世, 宮本昌宜, 香川清澄, 根宜典行, 日下亜起子, 高橋哲, 明石昌也, 筧康正

  (公社)日本診療放射線技師会, Sep. 2017, 日本診療放射線技師会誌, 64(9) (9), 1220 - 1220, Japanese


• 重症心身障害者における動揺歯チェック表を用いた動揺歯の脱落予防に対する取り組み

  後藤 佳代子, 柴田 里紗, 明石 昌也, 玉村 宣尚

  日本重症心身障害学会, Aug. 2017, 日本重症心身障害学会誌, 42(2) (2), 257 - 257, Japanese


• 顎口腔領域の重症感染症例の検討

  高橋 淳子, 古土井 春吾, 岸本 恵実, 岩田 英治, 楠元 順哉, 梶 真人, 後藤 育子, 明石 昌也, 古森 孝英

  (一社)日本口腔感染症学会, Jul. 2017, 日本口腔感染症学会雑誌, 24(1) (1), 14 - 20, Japanese


• スニチニブに関連して発症したと考えられる下顎骨壊死の1例

  岩田 英治, 古土井 春吾, 岸本 恵実, 藤林 淳子, 楠元 順哉, 後藤 育子, 明石 昌也, 古森 孝英

  (一社)日本口腔感染症学会, Jul. 2017, 日本口腔感染症学会雑誌, 24(1) (1), 51 - 51, Japanese


• 口腔癌術後に消化管穿孔を発症した1例

  高橋 淳子, 古土井 春吾, 岸本 恵実, 岩田 英治, 楠元 順哉, 梶 真人, 後藤 育子, 明石 昌也, 古森 孝英

  (一社)日本口腔感染症学会, Jul. 2017, 日本口腔感染症学会雑誌, 24(1) (1), 54 - 55, Japanese


• 結節性硬化症患者に対する口腔衛生管理の現状 エベロリムスによる口内炎への対応

  西井 美佳, 古土井 春吾, 岸本 恵実, 岩田 英治, 楠元 順哉, 明石 昌也, 古森 孝英

  (一社)日本口腔感染症学会, Jul. 2017, 日本口腔感染症学会雑誌, 24(1) (1), 61 - 61, Japanese


• 当院における顎骨骨髄炎外来の現状と役割

  岩田 英治, 古土井 春吾, 鰐渕 聡, 明石 昌也, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2017, 日本口腔科学会雑誌, 66(2) (2), 192 - 192, Japanese


• 当科における予防的頸部郭清術に関する後ろ向き検討

  松田 彩, 筧 康正, 正井 友里子, 米澤 奈津季, 榊原 晶子, 長谷川 巧実, 明石 昌也, 南川 勉, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2017, 日本口腔科学会雑誌, 66(2) (2), 113 - 113, Japanese


• 口腔扁平上皮癌における術後早期(1年以内)の予後不良例に関する臨床的検討

  正井 友里子, 南川 勉, 松田 彩, 米澤 奈津季, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2017, 日本口腔科学会雑誌, 66(2) (2), 114 - 114, Japanese


• 4DCTによる咀嚼時の下顎頭前方滑走の解析

  明石昌也, 大槻有美, 黄文蘇, 筧康正, 古森孝英

  (一社)日本顎関節学会, Jul. 2017, 日本顎関節学会雑誌, 29(Suppl.) (Suppl.), 92 - 92, Japanese


• 口腔癌手術における嚥下改善手術に関する臨床的検討

  筧 康正, 南川 勉, 正井 友里子, 松田 彩, 米澤 奈津季, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2017, 日本口腔科学会雑誌, 66(2) (2), 114 - 114, Japanese


• 両腋窩動脈狭窄症によりスティール症候群をきたし手指切断に至った透析患者の一例

  豊田 大祐, 加藤 敏輝, 芝田 圭佑, 齋藤 謙司, 花田 昌也, 明石 晋太郎

  (一社)日本透析医学会, May 2017, 日本透析医学会雑誌, 50(Suppl.1) (Suppl.1), 756 - 756, Japanese


• CAT分類における下顎骨切除範囲別の咀嚼機能と口腔QOLの評価

  前田 道徳, 渋谷 恭之, 明石 昌也, 古森 孝英

  (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 170 - 170, Japanese


• 神経症状を伴った下顎放射線性顎骨壊死における下歯槽神経の病理組織学的研究

  明石 昌也, 楠元 順哉, 長谷川 巧実, 南川 勉, 橋川 和信, 古森 孝英

  (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 189 - 189, Japanese


• 頭頸部癌化学放射線治療患者における口腔内細菌数と口腔粘膜水分量の解析

  西井美佳, 筧康正, 難波渚, 澤田麻衣子, 岩田英治, 長谷川巧実, 明石昌也, 古土井春吾, 古森孝英

  (一社)日本口腔ケア学会, Apr. 2017, 日本口腔ケア学会雑誌, 11(3) (3), 121 - 121, Japanese


• チタンミニプレートと固定用スクリューの関与が疑われた乾癬様皮疹の1例

  可信 雅彦, 明石 昌也, 古土井 春吾, 古森 孝英

  (NPO)日本口腔科学会, Mar. 2017, 日本口腔科学会雑誌, 66(1) (1), 54 - 54, Japanese


• 口腔癌放射線治療における新規併用療法の開発

  岩田英治, 長谷川巧実, 武田大介, 斎藤泉, 有本智美, 明石昌也, 南川勉, 古森孝英

  2017, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 35th


• 神戸大学医学部附属病院における心臓血管外科患者に対する周術期口腔機能管理の現状

  藤 大補, 古土井 春吾, 明石 昌也, 西井 美佳, 古森 孝英

  (一社)日本口腔感染症学会, Jan. 2017, 日本口腔感染症学会雑誌, 23(2) (2), 43 - 47, Japanese


• 当科における予防的頸部郭清術に関する後ろ向き検討

  松田彩, 筧康正, 正井友里子, 米澤奈津季, 榊原晶子, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

  2017, 日本口腔科学会学術集会プログラム・抄録集, 71st, 181, Japanese


• 口腔扁平上皮癌における術後早期(1年以内)の予後不良例に関する臨床的検討

  正井友里子, 南川勉, 松田彩, 米澤奈津季, 筧康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2017, 日本口腔科学会学術集会プログラム・抄録集, 71st, 183, Japanese


• 口腔癌手術における嚥下改善手術に関する臨床的検討

  筧康正, 南川勉, 正井友里子, 松田彩, 米澤奈津季, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2017, 日本口腔科学会学術集会プログラム・抄録集, 71st, 183, Japanese


• Risk factors associated with oroantral perforation during surgical removal of maxillary third molar teeth.

  Takumi Hasegawa, Akira Tachibana, Daisuke Takeda, Eiji Iwata, Satomi Arimoto, Akiko Sakakibara, Masaya Akashi, Takahide Komori

  PURPOSE: The relationship between radiographic findings and the occurrence of oroantral perforation is controversial. Few studies have quantitatively analyzed the risk factors contributing to oroantral perforation, and no study has reported multivariate analysis of the relationship(s) between these various factors. This retrospective study aims to fill this void. METHODS: Various risk factors for oroantral perforation during maxillary third molar extraction were investigated by univariate and multivariate analysis. The proximity of the roots to the maxillary sinus floor (root-sinus [RS] classification) was assessed using panoramic radiography and classified as types 1-5. The relationship between the maxillary second and third molars was classified according to a modified version of the Archer classification. The relative depth of the maxillary third molar in the bone was classified as class A-C, and its angulation relative to the long axis of the second molar was also recorded. RESULTS: Performance of an incision (OR 5.16), mesioangular tooth angulation (OR 6.05), and type 3 RS classification (i.e., significant superimposition of the roots of all posterior maxillary teeth with the sinus floor; OR 10.18) were all identified as risk factors with significant association to an outcome of oroantral perforation. CONCLUSION: To our knowledge, this is the first multivariate analysis of the risk factors for oroantral perforation during surgical extraction of the maxillary third molar. This RS classification may offer a new predictive parameter for estimating the risk of oroantral perforation.

  Dec. 2016, Oral and maxillofacial surgery, 20(4) (4), 369 - 375, English, International magazine


• 当科におけるインプラント埋入症例と喪失リスクに関する臨床的検討

  片岡 侑嗣, 長谷川 巧実, 綿越 健太, 浅井 雅敏, 有本 智美, 明石 昌也, 鈴木 泰明, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2016, Japanese Journal of Maxillo Facial Implants, 15(3) (3), 218 - 218, Japanese


• 内視鏡支援下で上顎洞迷入インプラントの摘出後に骨造成術を行った1例

  山下淳也, 山下淳也, 鈴木泰明, 筧康正, 木本明, 長谷川巧実, 明石昌也, 古森孝英

  (公社)日本顎顔面インプラント学会, Nov. 2016, Japanese Journal of Maxillo Facial Implants, 15(3) (3), 207 - 207, Japanese


• 放射線性顎骨壊死症例に対する画像診断を中心とした臨床的検討

  鰐渕 聡, 明石 昌也, 岩田 英治, 楠元 順哉, 松本 耕祐, 南川 勉, 古土井 春吾, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2016, 日本口腔科学会雑誌, 65(2) (2), 130 - 131, Japanese


• 当科における埋伏智歯抜歯後神経系合併症に対する治療法の現状

  平岡 佑二郎, 明石 昌也, 松本 耕祐, 榊原 晶子, 木本 明, 長谷川 巧実, 鈴木 泰明, 南川 勉, 古土井 春吾, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2016, 日本口腔科学会雑誌, 65(2) (2), 176 - 177, Japanese


• 当科における歯性上顎洞炎の臨床的検討

  岩田 英治, 明石 昌也, 岸本 恵実, 藤林 淳子, 楠元 順哉, 古土井 春吾, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2016, 日本口腔科学会雑誌, 65(2) (2), 220 - 221, Japanese


• 化学放射線療法による口腔粘膜炎の重症度を予測する因子についての検討

  岸本 恵実, 古土井 春吾, 藤林 淳子, 岩田 英治, 楠元 順哉, 梶 真人, 後藤 育子, 明石 昌也, 古森 孝英

  (一社)日本口腔感染症学会, Jul. 2016, 日本口腔感染症学会雑誌, 23(1) (1), 21 - 22, Japanese


• 歯性感染症が原因となった脳膿瘍の2例

  藤林 淳子, 古土井 春吾, 岸本 恵実, 岩田 英治, 楠元 順哉, 梶 真人, 後藤 育子, 明石 昌也, 古森 孝英

  (一社)日本口腔感染症学会, Jul. 2016, 日本口腔感染症学会雑誌, 23(1) (1), 25 - 26, Japanese


• 脳神経外科術後の顎関節症の臨床的検討

  大槻 有美, 明石 昌也, 黄 文蘇, 古森 孝英

  (一社)日本顎関節学会, Jul. 2016, 日本顎関節学会雑誌, 28(Suppl.) (Suppl.), 111 - 111, Japanese


• 顎関節に生じた滑膜骨軟骨腫症の1例

  黄 文蘇, 明石 昌也, 大槻 有美, 橘 進彰, 古森 孝英

  (一社)日本顎関節学会, Jul. 2016, 日本顎関節学会雑誌, 28(Suppl.) (Suppl.), 153 - 153, Japanese


• 下顎骨骨折の治療を行ったLennox-Gastaut症候群患児の1例

  中西 洋介, 松本 耕祐, 小守 紗也華, 長谷川 巧実, 明石 昌也, 柚鳥 宏和, 橘 進彰, 古森 孝英

  (一社)日本外傷歯学会, Jul. 2016, 日本外傷歯学会総会・学術大会プログラム・抄録集, 16回, 41 - 41, Japanese


• 当科におけるFibro-osseous lesionsの臨床的検討

  松尾 健司, 明石 昌也, 筧 康正, 松本 耕祐, 長谷川 巧実, 南川 勉, 古土井 春吾, 橘 進彰, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2016, 日本口腔科学会雑誌, 65(2) (2), 127 - 128, Japanese


• 遺伝子解析により確定診断を得た頬粘膜MALTリンパ腫の1例

  筧 康正, 明石 昌也, 木本 明, 長谷川 巧実, 南川 勉, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2016, 日本口腔科学会雑誌, 65(2) (2), 214 - 214, Japanese


• 当院における過去8年間の外傷歯患者の臨床統計的検討~顎骨骨折の有無と外傷歯の関係について~

  可信雅彦, 筧康正, 明石昌也, 古森孝英

  (一社)日本外傷歯学会, Jul. 2016, 日本外傷歯学会総会・学術大会プログラム・抄録集, 16回, 29 - 29, Japanese


• 全身麻酔挿管中に生じる歯牙損傷の後ろ向き調査

  小守紗也華, 筧康正, 明石昌也, 古森孝英

  (一社)日本外傷歯学会, Jul. 2016, 日本外傷歯学会総会・学術大会プログラム・抄録集, 16回, 30 - 30, Japanese


• 当科における顎関節症脱臼の臨床的検討

  大槻有美, 明石昌也, 黄文蘇, 筧康正, 古森孝英

  (一社)日本顎関節学会, Jul. 2016, 日本顎関節学会雑誌, 28(Suppl.) (Suppl.), 130 - 130, Japanese


• 4D-CTによる下顎再建術後患者の咀嚼の観察

  明石 昌也, 橋川 和信, 渋谷 恭之, 寺師 浩人, 古森 孝英

  (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2) (2), 147 - 147, Japanese


• 歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価

  明石 昌也, 橋川 和信, 鰐渕 聡, 楠元 順哉, 長谷川 巧実, 南川 勉, 寺師 浩人, 古森 孝英

  (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2) (2), 147 - 147, Japanese


• 下顎枝垂直骨切り術後の骨癒合に対する低出力超音波パルス(LIPUS)の効果

  有本 智美, 長谷川 巧実, 岡本 奈々, 塩屋園 敦, 立石 千鶴, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英

  (NPO)日本顎変形症学会, May 2016, 日本顎変形症学会雑誌, 26(2) (2), 183 - 183, Japanese


• 当科における心臓血管外科周術期の口腔機能管理に関する実態と今後の課題

  難波 渚, 西井 美佳, 田村 恵利, 富田 和, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英

  (一社)日本口腔ケア学会, Mar. 2016, 日本口腔ケア学会雑誌, 10(1) (1), 199 - 199, Japanese


• 当院における周術期口腔機能管理に関する実態調査と今後の課題

  田村 惠利, 西井 美佳, 冨田 和, 難波 渚, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英

  (一社)日本口腔ケア学会, Mar. 2016, 日本口腔ケア学会雑誌, 10(1) (1), 225 - 225, Japanese


• 再建プレート露出に対する二期再建術前PET/CTが膿瘍の検知に有用であった1例

  松尾 健司, 明石 昌也, 楠元 順也, 藤林 淳子, 渡邊 一博, 南川 勉, 橋川 和信, 古森 孝英

  (NPO)日本口腔科学会, Mar. 2016, 日本口腔科学会雑誌, 65(1) (1), 69 - 69, Japanese


• 口腔扁平上皮癌における外的刺激受容体(TRPVチャネル)の発現亢進

  榊原晶子, 榊原俊介, 楠元順哉, 楠元順哉, 武田大介, 長谷川巧実, 明石昌也, 南川勉, 橋川和信, 古森孝英

  2016, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th


• 当科におけるFibro‐osseous lesionsの臨床的検討

  松尾健司, 明石昌也, 筧康正, 松本耕祐, 長谷川巧実, 南川勉, 古土井春吾, 橘進彰, 古森孝英

  2016, 日本口腔科学会学術集会プログラム・抄録集, 70th, 159, Japanese


• 術前18F‐FDG PET/CT撮影での口腔癌原発巣における定量評価の有用性

  米澤奈津季, 南川勉, 北島一宏, 高橋佑輔, 筧康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2016, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 231, Japanese


• 口腔扁平上皮癌被膜外浸潤症例の臨床病理学的検討

  筧康正, 南川勉, 寺岡駿, 米澤奈津季, 高橋佑輔, 長谷川巧実, 明石昌也, 古森孝英

  2016, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 234, Japanese


• 口腔扁平上皮癌患者の遠位レベル(Level4,5)への頸部リンパ節転移が予後に与える影響

  定兼啓倫, 長谷川巧実, 渋谷恭之, 渋谷恭之, 米澤奈津季, 武田大介, 高橋佑輔, 筧康正, 明石昌也, 南川勉, 古森孝英

  2016, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 221, Japanese


• 局所的炭酸ガス投与による皮弁壊死抑制効果

  齊藤泉, 長谷川巧実, 武田大介, 岩田英治, 有本智美, 筧康正, 高橋佑輔, 榊原晶子, 明石昌也, 南川勉, 古森孝英

  2016, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 208, Japanese


• 遺伝子解析により確定診断を得た頬粘膜MALTリンパ腫の1例

  筧康正, 明石昌也, 木本明, 長谷川巧実, 南川勉, 古森孝英

  2016, 日本口腔科学会学術集会プログラム・抄録集, 70th, 286, Japanese


• 移植腓骨と下顎骨の癒合における骨膜温存の重要性

  明石昌也, 筧康正, 榊原晶子, 長谷川巧実, 南川勉, 橋川和信, 古森孝英

  2016, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 208, Japanese


• Targeted Disruption of JCAD/KIAA1462, a Coronary Artery Disease-associated Gene Product, Inhibits Angiogenic Processes in Vitro and in Vivo

  Tetsuya Hara, Tomoko Monguchi, Masaya Akashi, Noriko Iwamoto, Kenta Mori, Ryuji Toh, Yasuhiro Irino, Masakazu Shinohara, Mikio Furuse, Tatsuro Ishida, Ken-ichi Hirata

  Nov. 2015, CIRCULATION, 132, English

  Summary international conference


• 入院加療を要した口腔頸部の重症感染症例の検討

  藤林 淳子, 古土井 春吾, 畑 みどり, 楠元 順哉, 後藤 育子, 明石 昌也, 古森 孝英

  (一社)日本口腔感染症学会, May 2015, 日本口腔感染症学会雑誌, 22(1) (1), 35 - 36, Japanese


• 口腔扁平上皮癌臨床検体におけるミトコンドリア量について

  武田大介, 長谷川巧実, 今井佑輔, 榊原晶子, 明石昌也, 南川勉, 古森孝英

  2015, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd


• Clinical investigation of vascular malformations of the oral region treated by multiple photocoagulation with an Nd:YAG laser

  Matsumoto Kousuke, Ono Masataka, Kitayama Midori, Akashi Masaya, Suzuki Hiroaki, Komori Takahide

  Japanese Stomatological Society, 2015, Oral science in Japan, 63 - 65, English


• Clinical analysis of the chronological change in bone mass following sinus floor elevation

  Suzuki Hiroaki, Matsumoto Kousuke, Enomoto Yui, Kakei Yasumasa, Kimoto Akira, Akashi Masaya, Komori Takahide

  Japanese Stomatological Society, 2015, Oral science in Japan, 79 - 82, English


• 当科における頸部郭清術術後の頸部ドレーンに関する臨床的検討

  齊藤泉, 長谷川巧実, 米澤奈津季, 武田大介, 高橋佑輔, 筧康正, 松井太輝, 榊原晶子, 明石昌也, 南川勉, 古森孝英

  2015, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 295, Japanese


• 当科における放射線性顎骨壊死に関する臨床的検討

  鰐渕聡, 明石昌也, 筧康正, 榊原晶子, 長谷川巧実, 南川勉, 古森孝英

  2015, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 237, Japanese


• 当科における口腔扁平上皮癌遠隔転移例の臨床的検討とリスク因子について

  棚倉万紀子, 長谷川巧実, 米澤奈津季, 武田大介, 高橋佑輔, 筧康正, 松井太輝, 榊原晶子, 明石昌也, 南川勉, 古森孝英

  2015, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 301, Japanese


• 口腔癌原発巣におけるDual‐time‐point FDG PETの有用性に関する検討

  米澤奈津季, 南川勉, 高橋佑輔, 筧康正, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2015, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 188, Japanese


• 【全身疾患と抜歯-最新の知識による適切な対応-】 全身疾患を有する患者の抜歯の際に注意すべき基本的事項

  Komori Takahide, Akashi Masaya, Suzuki Yasuaki, 榊原晶子, Kimoto Akira, Minamikawa Tsutomu, Hasegawa Takumi, Furudoi Shungo

  (株)第一歯科出版, Jan. 2015, 歯科医療, 29(1) (1), 4 - 10, Japanese

  [Invited]

  Introduction scientific journal


• 【全身疾患と抜歯-最新の知識による適切な対応-】 循環器系疾患を有する患者の抜歯

  Akashi Masaya, Komori Takahide

  (株)第一歯科出版, Jan. 2015, 歯科医療, 29(1) (1), 11 - 18, Japanese

  [Invited]

  Introduction commerce magazine


• 遊離腓骨皮弁移植におけるMR Angiographyと超音波検査による下肢血管解剖の術前評価

  楠元 順哉, 橋川 和信, 寺師 浩人, 明石 昌也, 榊原 晶子

  (一社)日本形成外科学会, Nov. 2014, 日本形成外科学会会誌, 34(11) (11), 852 - 853, Japanese


• 当科における広範囲顎骨支持型インプラント補綴の臨床統計的検討

  今井 佑輔, 長谷川 巧実, 川畑 真哉, 武田 大介, 明石 昌也, 鈴木 泰明, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2014, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 128 - 128, Japanese


• 著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った1例

  榎本 由依, 鈴木 泰明, 木本 明, 長谷川 巧実, 明石 昌也, 浅井 知子, 竹内 純一郎, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2014, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 144 - 144, Japanese


• 当科におけるインプラント242例907本埋入に関する臨床的検討

  川畑 真哉, 長谷川 巧実, 今井 佑輔, 木本 明, 明石 昌也, 鈴木 泰明, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2014, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 160 - 160, Japanese


• 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価

  明石 昌也, 渋谷 恭之, 鰐渕 聡, 木本 明, 長谷川 巧実, 鈴木 泰明, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2014, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 166 - 166, Japanese


• 再発胃癌切除後に生じた胸腹壁欠損に対する治療経験

  長谷川 泰子, Nomura Tadashi, 橋川 和信, 寺師 浩人, 明石 昌也, 前田 翔

  (一社)日本形成外科学会, Nov. 2014, 日本形成外科学会会誌, 34(11) (11), 851 - 851, Japanese

  Others


• Preformed Reconstruction plateで下顎再建を行った2症例

  竹内 惇平, 明石 昌也, 藤 大補, 高橋 佑輔, 古土井 春吾, 榊原 晶子, 南川 勉, 渋谷 恭之, 古森 孝英

  (NPO)日本口腔科学会, Sep. 2014, 日本口腔科学会雑誌, 63(4) (4), 350 - 350, Japanese


• 放射線性口腔粘膜炎の重症度判定の客観性を高めるための方策

  川下 由美子, 林田 咲, 船原 まどか, 齋藤 俊行, 西井 美佳, 後藤 郁子, 明石 昌也, 古土井 春吾, 古森 孝英, 梅田 正博

  (NPO)日本口腔科学会, Sep. 2014, 日本口腔科学会雑誌, 63(4) (4), 358 - 358, Japanese


• 造血器悪性腫瘍患者への歯科的介入に関する前向き検討

  辻 和志, 渋谷 恭之, 岸本 恵実, 明石 昌也, 古土井 春吾, 古森 孝英

  (NPO)日本口腔科学会, Sep. 2014, 日本口腔科学会雑誌, 63(4) (4), 376 - 376, Japanese


• 口腔癌再建術後の頸部感染評価目的でのCTの有用性

  明石 昌也, 古土井 春吾, 南川 勉, 木本 明, 榊原 晶子, 長谷川 巧実, 後藤 育子, 渋谷 恭之, 古森 孝英

  (NPO)日本口腔科学会, Sep. 2014, 日本口腔科学会雑誌, 63(4) (4), 381 - 381, Japanese


• ビスフォスフォネート関連顎骨壊死症例の転帰に影響する因子についての検討

  古土井 春吾, 楠元 順哉, 畑 みどり, 藤林 淳子, 梶 真人, 後藤 育子, 明石 昌也, 吉位 尚, 古森 孝英

  (一社)日本口腔感染症学会, Jun. 2014, 日本口腔感染症学会雑誌, 21(1) (1), 2 - 7, Japanese


• 当科における重症歯性感染症例の臨床的検討

  藤林 淳子, 古土井 春吾, 小松原 秀紀, 楠元 順哉, 後藤 育子, 明石 昌也, 古森 孝英

  (一社)日本口腔感染症学会, Jun. 2014, 日本口腔感染症学会雑誌, 21(1) (1), 49 - 49, Japanese


• 過去15年間の高齢口腔癌患者に関する臨床的検討

  米澤 奈津季, 南川 勉, 高橋 佑輔, 明石 昌也, 渋谷 恭之, 古森 孝英

  (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 158 - 158, Japanese


• 口腔癌再建術後の感染性合併症 術後CRPのabnormal responseに注目して

  明石 昌也, 橋川 和信, 南川 勉, 渋谷 恭之, 古森 孝英

  (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 182 - 182, Japanese


• 放射線誘発癌が疑われた口腔癌に対する遊離皮弁再建

  明石 昌也, 橋川 和信, 寺師 浩人

  (一社)日本形成外科学会, Mar. 2014, 日本形成外科学会会誌, 34(3) (3), 238 - 238, Japanese


• 口腔外に肉芽形成をきたしたビスフォスフォネート関連顎骨壊死の1例

  岩田 英治, 古土井 春吾, 楠元 順哉, 後藤 育子, 明石 昌也, 古森 孝英

  (NPO)日本口腔科学会, Mar. 2014, 日本口腔科学会雑誌, 63(2) (2), 246 - 246, Japanese


• 造血器悪性腫瘍患者への歯科的介入に関する前向き検討

  辻 和志, 渋谷 恭之, 明石 昌也, 古土井 春吾, 古森 孝英

  (NPO)日本口腔科学会, Jan. 2014, 日本口腔科学会雑誌, 63(1) (1), 65 - 66, Japanese


• 口腔癌cN1症例に対する頸部郭清術の郭清範囲についての検討

  筧康正, 南川勉, 高橋佑輔, 松井太輝, 長谷川巧実, 明石昌也, 重田崇至, 古土井春吾, 渋谷恭之, 古森孝英

  2014, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 32nd, 172, Japanese


• 舌癌180例のリンパ節転移に関する検討~健側転移について~

  松井太輝, 重田崇至, 南川勉, 明石昌也, 高橋佑輔, 筧康正, 古土井春吾, 渋谷恭之, 古森孝英

  2013, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 31st, 140, Japanese


• 口腔扁平上皮癌術後局所再発症例に関する検討

  高橋佑輔, 南川勉, 筧康正, 松井太輝, 榊原晶子, 明石昌也, 重田崇至, 渋谷恭之, 古森孝英

  2013, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 31st, 141, Japanese


• 口腔扁平上皮癌T4症例に対する手術療法の治療成績

  筧康正, 南川勉, 高橋佑輔, 松井太輝, 榊原晶子, 明石昌也, 重田崇至, 古土井春吾, 渋谷恭之, 古森孝英

  2013, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 31st, 144, Japanese


• プレート破折後に遊離腓骨皮弁で下顎骨再建を行った1例

  Akashi Masaya, Hashikawa Kazunobu, Tahara Shinya

  (一社)日本形成外科学会, Sep. 2012, 日本形成外科学会会誌, 32(9) (9), 711 - 712, Japanese

  [Refereed]

  Meeting report


• 骨髄移植後GVHD患者に発生した口腔扁平上皮癌の2例

  筧康正, 南川勉, 松井太輝, 榊原晶子, 明石昌也, 三浦真香, 重田崇至, 小松原秀紀, 渋谷恭之, 古森孝英

  2012, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 30th, 211, Japanese


• 口腔扁平上皮癌に対する頸部郭清術施行205例の頸部転移様相

  松井 太輝, 重田 崇至, 高橋 英哲, 高橋 佑輔, 明石 昌也, 南川 勉, 渋谷 恭之, 梅田 正博, 古森 孝英

  (公社)日本口腔外科学会, Sep. 2011, 日本口腔外科学会雑誌, 57(Suppl.) (Suppl.), 99 - 99, Japanese


• 口腔に発生した紡錘細胞癌における肺転移巣の倍加時間について

  重田 崇至, 南川 勉, 小松原 秀紀, 榊原 晶子, 明石 昌也, 高橋 英哲, 松井 太輝, 渋谷 恭之, 梅田 正博, 古森 孝英

  (公社)日本口腔外科学会, Sep. 2011, 日本口腔外科学会雑誌, 57(Suppl.) (Suppl.), 191 - 191, Japanese


• 顎口腔再建におけるフェーズコントラスト型CT Angiographyの有用性について

  明石 昌也, 橋川 和信, 南川 勉, 重田 崇至, 榊原 晶子, 古土井 春吾, 渋谷 恭之, 古森 孝英

  (公社)日本口腔外科学会, Sep. 2011, 日本口腔外科学会雑誌, 57(Suppl.) (Suppl.), 215 - 215, Japanese


• 舌癌のstage I・II症例における臨床的検討について

  西村 裕貴, 重田 崇至, 高橋 佑輔, 松井 太輝, 高橋 英哲, 榊原 晶子, 明石 昌也, 南川 勉, 渋谷 恭之, 梅田 正博, 古森 孝英

  (公社)日本口腔外科学会, Sep. 2011, 日本口腔外科学会雑誌, 57(Suppl.) (Suppl.), 324 - 324, Japanese


• 当科における口底扁平上皮癌手術症例の臨床病理学的検討

  筧 康正, 南川 勉, 松井 太輝, 高橋 英哲, 榊原 晶子, 明石 昌也, 重田 崇至, 渋谷 恭之, 梅田 正博, 古森 孝英

  (公社)日本口腔外科学会, Sep. 2011, 日本口腔外科学会雑誌, 57(Suppl.) (Suppl.), 200 - 200, Japanese


• 口腔癌手術における嚥下改善手術に関する臨床的検討

  明石 昌也, 南川 勉, 高橋 英哲, 小國 晶子, 橋川 和信, 古土井 春吾, 渋谷 恭之, 梅田 正博, 古森 孝英

  (公社)日本口腔外科学会, Sep. 2010, 日本口腔外科学会雑誌, 56(Suppl.) (Suppl.), 140 - 140, Japanese


• 外側舌リンパ節転移を認めた口底癌の1例

  木本 明, 南川 勉, 小林 正樹, 服部 真季, 明石 昌也, 澁谷 恭之, 横尾 聡, 梅田 正博, 古森 孝英

  (公社)日本口腔外科学会, Jun. 2007, 日本口腔外科学会雑誌, 53(6) (6), 400 - 400, Japanese


• 顎関節症患者の臨床統計的検討

  渋谷 恭之, 竹内 純一郎, 池端 伯子, 藤田 剛史, 明石 昌也, 古森 孝英

  (一社)日本顎関節学会, Apr. 2006, 日本顎関節学会雑誌, 18(1) (1), 48 - 48, Japanese


• 当科における顎関節症III a患者の臨床統計的検討

  竹内 純一郎, 渋谷 恭之, 池端 伯子, 藤田 剛史, 明石 昌也, 古森 孝英

  (一社)日本顎関節学会, Apr. 2006, 日本顎関節学会雑誌, 18(1) (1), 48 - 48, Japanese


• 当科における顎関節症I・II患者の臨床統計的検討

  池端 伯子, 渋谷 恭之, 竹内 純一郎, 明石 昌也, 藤田 剛史, 古森 孝英

  (一社)日本顎関節学会, Apr. 2006, 日本顎関節学会雑誌, 18(1) (1), 80 - 80, Japanese


• 当科における顎関節症III b型患者の臨床統計的検討

  藤田 剛史, 渋谷 恭之, 竹内 純一郎, 池端 伯子, 明石 昌也, 古森 孝英

  (一社)日本顎関節学会, Apr. 2006, 日本顎関節学会雑誌, 18(1) (1), 80 - 81, Japanese


• 当科における顎関節症IV型患者の臨床統計的検討

  明石 昌也, 渋谷 恭之, 竹内 純一郎, 池端 伯子, 藤田 剛史, 古森 孝英

  (一社)日本顎関節学会, Apr. 2006, 日本顎関節学会雑誌, 18(1) (1), 81 - 81, Japanese

• 改訂版日常の口腔外科 病診連携１ＳＭＡＲＴ＆ＳＭＯＯＴＨ / V-7 顎関節疾患治療の概要を知る

  古森孝英, 横尾聡, 古土井春吾, 綿谷早苗, 梅田正博, 渋谷恭之, 藤岡学, 立石千鶴, 南川勉, 松本耕祐, 榊原晶子, 鈴木泰明, Akashi Masaya

  Others, 永末書店, 2018, Japanese

  Textbook


• Oral and Craniofacial Diseases and Disorders / Capter 2: Complications Following Radiation Therapy for Head and Neck Malignancy

  AkashiM, Komori Takahide, MinamikawaT, Hasegawa Takumi, NishiiM, HashikawaK, SeddikMH, SasakiR

  Others, Oxford University Press, 2018, English

  Scholarly book


• OPEN ACCESS e Books: Oral and Craniofacial Disease and Disorders. / Oral complications following radiation theraphy for head anad neck malignancy

  Akashi Masaya, KomoriT, MinamikawaT, HasegawaT, NishiiM, HashikawaH, SeddikMH, SasakiR

  Others, －, 2018, English

  Scholarly book


• 新こんな患者さんが歯科に来たときは？全身疾患・口腔外科疾患に対する診療マニュアル / 味覚障害への対応

  Akashi Masaya, 鄒天皓

  Others, 第一歯科出版, 2014, Japanese

  General book


• 新こんな患者さんが歯科に来たときは？全身疾患・口腔外科疾患に対する診療マニュアル / 腎障害患者への対応

  Akashi Masaya, 大槻有美, 若林玲奈, 高橋英哲

  Others, 第一歯科出版, 2014, Japanese

  General book


• 新こんな患者さんが歯科に来たときは？全身疾患・口腔外科疾患に対する診療マニュアル / 三叉神経痛への対応

  Akashi Masaya, 藤原健一, 高田直樹

  Others, 第一歯科出版, 2014, Japanese

  General book

• 心血管外科手術周術期の口腔機能管理に関する臨床的検討

  難波渚, Akashi Masaya, Komori Takahide, 桶本翔吾, 小槇 公大, 小川 真人, 坪井 康典, Kobayashi Seimi, Gotake Yasuko, Okita Yutaka

  第3回日本心臓リハビリテーション学会近畿地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference

  Oral presentation


• 下顎骨壊死における下歯槽神経障害の臨床病理学的検討

  平岡佑二郎, AKASHI MASAYA, SHIGEOKA MANABU, 楠元順哉, HASEGAWA TAKUMI, KOMORI TAKAHIDE

  第62回日本口腔外科学会総会・学術大会, Oct. 2017, Japanese, 京都, Domestic conference

  Oral presentation


• FDG PET-CTは重症下顎放射線性顎骨壊死の切除範囲決定に有用か?．

  Akashi Masaya, Hashikawa Kazunobu, 楠元順哉, Furudoi Shungo, Komori Takahide

  第62回日本口腔外科学会総会・学術大会（京都）, Oct. 2017, Japanese, 日本口腔外科学会, 京都, Domestic conference

  Public symposium


• 神経症状を伴った下顎放射線性顎骨壊死における下歯槽神経の病理組織学的研究．

  Akashi Masaya, 楠元順哉, Hasegawa Takumi, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第41回日本頭頸部癌学会（京都）, Jun. 2017, Japanese, 日本頭頸部癌学会, 京都, Domestic conference

  Oral presentation


• 【シンポジウム2「頭頸部再建に残された課題－二次再建の挑戦と課題－」】重症下顎骨放射線骨髄炎に対する手術―デブリドマン範囲を病理組織学的検討結果から考察する―．

  Hashikawa Kazunobu, Akashi Masaya, 楠元順哉, Nomura Tadashi, Terashi Hiroto

  第60回日本形成外科学会総会・学術集会（大阪）, Apr. 2017, Japanese, 日本形成外科学会, 大阪, Domestic conference

  Public symposium


• 4DCT EVALUATION OF CONDYLAR MOVEMEN IN PATIENTS UNDERWENT MANDIBULAR RECONSTRUCTION．

  Akashi Masaya, Toshinori Sekitani, Yumi Ohtsuki, Yasumasa Kakei, Hasegawa Takumi, Noriyuki Negi, Hashikawa Kazunobu, Yasuyuki Shibuya, Takahashi Satoru, Komori Takahide

  23nd International Conference on Oral and Maxillofacial Surgery（Hong Kong）, Mar. 2017, Japanese, International Conference on Oral and Maxillofacial Surgery, Hong Kong, 海外, Domestic conference

  Oral presentation


• 口腔扁平上皮癌では外的刺激受容体（TRPVチャネル）の発現が亢進する．

  Sakakibara Akiko, 榊原俊介, 楠元順哉, 武田大介, Hasegawa Takumi, Akashi Masaya, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第35回口腔腫瘍学会（福岡）, Jan. 2017, Japanese, 口腔腫瘍学会, 福岡, Domestic conference

  Oral presentation


• 内視鏡支援下で上顎洞迷入インプラントの摘出後に骨造成術を行った1例

  山下淳也, Suzuki Yasuaki, 筧康正, 木本 明, Hasegawa Takumi, Akashi Masaya, Komori Takahide

  第20回日本顎顔面インプラント学会, Dec. 2016, Japanese, 日本顎顔面インプラント学会, 東京, Domestic conference

  Poster presentation


• 当科におけるインプラント埋入症例と喪失リスクに関する臨床的検討

  片岡侑嗣, Hasegawa Takumi, 綿越健太, 浅井雅敏, 有本智美, Akashi Masaya, Suzuki Yasuaki, Komori Takahide

  第20回日本顎顔面インプラント学会, Dec. 2016, Japanese, 日本顎顔面インプラント学会, 東京, Domestic conference

  Poster presentation


• チタンミニプレートと固定用スクリューの関与が疑われた乾癬様皮疹の1例

  可信雅彦, Akashi Masaya, Furudoi Shungo, Komori Takahide

  第28回口腔科学会近畿地方部会, Dec. 2016, Japanese, 日本口腔科学会, 大阪, Domestic conference

  Oral presentation


• 腓骨皮弁による下顎再建におけるミニプレートと再建用プレートの比較

  平岡佑二郎, Akashi Masaya, 筧 康正, 楠元順哉, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 放射線性顎骨壊死の病理組織学的検討

  鰐渕 聡, Akashi Masaya, 岩田英治, 筧 康正, 楠元順哉, Minamikawa Tsutomu, Furudoi Shungo, Hashikawa Kazunobu, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 頭頸部領域の蜂窩識炎に対する好中球/リンパ球比，血小板/リンパ球比の有用性の検討

  楠元順哉, Furudoi Shungo, 岸本惠実, 岩田英治, Akashi Masaya, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 頭頸部蜂窩織炎に対する好中球/リンパ球比，血小板/リンパ球比の有用性の検討

  楠元 順哉, Furudoi Shungo, 岸本 恵実, 岩田 英治, 藤林 淳子, Akashi Masaya, Komori Takahide

  第61回公益社団法人日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 公益社団法人日本口腔外科学会総会・学術大会, 千葉市, Domestic conference

  Oral presentation


• 当科における舌癌・口底癌手術症例の再建方法に関する検討

  綿越健太, Minamikawa Tsutomu, 米澤奈津季, 筧 康正, Hasegawa Takumi, Sakakibara Akiko, Akashi Masaya, Furudoi Shungo, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 当科における心臓血管外科開胸手術患者に対する周術期口腔機能管理の臨床的検討

  難波 渚, Akashi Masaya, 西井美佳, 楠元順哉, Matsumoto Kousuke, Hasegawa Takumi, Furudoi Shungo, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 当科における口腔癌患者の口腔内細菌数の変化とSSIについて

  小守紗也華, Hasegawa Takumi, 西井美佳, Akashi Masaya, Furudoi Shungo, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 造血器悪性腫瘍患者に対する化学療法中の歯性感染症が原因の敗血症発症率

  岸本惠実, Akashi Masaya, 辻 和志, 楠元順哉, Furudoi Shungo, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 舌癌切除後の前腕皮弁再建における 切除検体サイズと皮弁サイズの 相関と機能の検討

  Sakakibara Akiko, 楠元 順哉, Hasegawa Takumi, Akashi Masaya, Minamikawa Tsutomu, Furudoi Shungo, Hashikawa Kazunobu, Komori Takahide

  第61回公益社団法人日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 公益社団法人日本口腔外科学会総会・学術大会, 千葉市, Domestic conference

  Oral presentation


• 舌癌切除後の前腕皮弁再建における切除検体サイズと皮弁サイズの僧冠と機能の検討

  Sakakibara Akiko, 楠元順哉, Hasegawa Takumi, Akashi Masaya, Minamikawa Tsutomu, Furudoi Shungo, Hashikawa Kazunobu, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 口腔癌放射線治療における有効な新規併用療法の探索

  岩田英治, Hasegawa Takumi, 武田大介, 斉藤 泉, 有本智美, Akashi Masaya, Minamikawa Tsutomu, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 口腔癌術後リンパ浮腫に関するCT解析

  寺岡 駿, Akashi Masaya, 筧 康正, 楠元順哉, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 局所的炭酸ガス投与による皮弁壊死抑制効果

  齊藤 泉, Hasegawa Takumi, 武田大介, 岩田英治, 有本智美, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 下顎枝垂直骨切り術後の骨癒合に対する低出力超音波パルス(LIPUS)の効果

  有本智美, Hasegawa Takumi, 齊藤 泉, 岩田英治, 武田大介, 立石千鶴, Akashi Masaya, Suzuki Yasuaki, Furudoi Shungo, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 遠位レベル(Level IV,V)への頸部リンパ節転移を生じた口腔扁平上皮癌患者の予後に関する後ろ向き観察研究

  Hasegawa Takumi, Minamikawa Tsutomu, 米澤奈津季, 高橋佑輔, 筧 康正, Sakakibara Akiko, Akashi Masaya, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 口腔癌術後に消化管穿孔を発症した1例

  高橋淳子, Furudoi Shungo, 岸本恵美, 岩田英治, 楠元順哉, 梶 真人, 後藤育子, Akashi Masaya, Komori Takahide

  第25回日本口腔感染症学会総会・学術大会, Oct. 2016, Japanese, 日本口腔感染症学会, 神戸, Domestic conference

  Oral presentation


• 結節性硬化症患者に対する口腔衛生管理の現状ーエベロリムスによる口内炎への対応ー

  西井美佳, Furudoi Shungo, 岸本惠実, 岩田英治, 楠元順哉, Akashi Masaya, Komori Takahide

  第25回日本口腔感染症学会総会・学術大会, Oct. 2016, Japanese, 日本口腔感染症学会, 神戸, Domestic conference

  Oral presentation


• スニチニブに関連して発症したと考えられる下顎骨壊死の1例

  岩田英治, Furudoi Shungo, 岸本惠実, 高橋淳子, 楠元順哉, 後藤育子, Akashi Masaya, Komori Takahide

  第25回日本口腔感染症学会総会・学術大会, Oct. 2016, Japanese, 日本口腔感染症学会, 神戸, Domestic conference

  Oral presentation


• Development of the new treatment of OSCC by local application of transcutaneous carbon dioxide

  Iwata E, Hasegawa Takumi, Takeda D, Saito Izumi, Arimoto S, Akashi Masaya, Minamikawa Tsutomu, Komori Takahide

  The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), Sep. 2016, Japanese, UKレーザー歯学会, London, UK, International conference

  Poster presentation


• Determination of resection margins by using a combination of CT, MRI, PET, and 3D model in osteoradionecrosis of the jaw

  Akashi Masaya, Hashikawa Kazunobu, Satoshi Wanifuchi, Megumi Kishimoto, Eiji Iwata, Yasumasa Kakei, Junya Kusumoto, Matsumoto Kousuke, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, Komori Takahide

  The 23th Congress of EACMFS, Sep. 2016, English, Congress of EACMFS, London, イギリス, International conference

  Oral presentation


• Determination of resection margins by using a combination of CT, MRI, PET, and 3D model in osteoradionecrosis of the jaw

  Akashi Masaya, Hashikawa Kazunobu, Wanifuchi S, Kishimoto M, Iwata E, Kakei Y, Kusumoto J, Matsumoto Kensuke, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, Komori Takahide

  The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), Sep. 2016, Japanese, UKレーザー歯学会, London, UK, International conference

  Poster presentation


• Changes of cell junctions induced by EGFR inhibition in oral squamous cell carcinomas

  Kakei Y, Akashi Masaya, Teraoka S, Hasegawa Takumi, Komori Takahide

  The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), Sep. 2016, Japanese, UKレーザー歯学会, London, UK, International conference

  Poster presentation


• A clinical study of injured patients treated with dental implants

  Suzuki Yasuaki, Takeuchi J, Matsuo K, Kakei Y, Kimoto A, Hasegawa Takumi, Akashi Masaya, Chikazu D, Komori Takahide

  The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), Sep. 2016, Japanese, UKレーザー歯学会, London, UK, International conference

  Poster presentation


• A clinical study of 12 implants resulting in implant removal

  Takahashi D, Suzuki Yasuaki, Kakei Y, Hasegawa Takumi, Akashi Masaya, Minamikawa Tsutomu, Komori Takahide

  The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS),, Sep. 2016, Japanese, UKレーザー歯学会, London, UK, International conference

  Poster presentation


• 頬部に認めた孤立性線維性腫瘍の1例

  鰐渕 聡, 大槻有美, 後藤育子, Akashi Masaya, Suzuki Yasuaki, Minamikawa Tsutomu, Furudoi Shungo, Komori Takahide

  第47回日本口腔外科学会近畿支部学術集会, Jul. 2016, Japanese, 日本口腔外科学会, 大阪, Domestic conference

  Oral presentation


• 脳神経外科術後の顎関節症の臨床的検討

  大槻有美, Akashi Masaya, 黄文蘇, 筧康正, Komori Takahide

  第29回日本顎関節学会総会・学術大会, Jul. 2016, Japanese, 日本顎関節学会, 箱根, Domestic conference

  Oral presentation


• 当科における心臓血管外科周術期の口腔機能管理に関する実態と今後の課題

  難波 渚, Akashi Masaya, 冨田 和, 田村恵利, 澤田麻衣子, 西井美佳, Hasegawa Takumi, Furudoi Shungo, Komori Takahide

  第32回兵庫県歯科医学大会, Jul. 2016, Japanese, 兵庫県歯科医師会, 神戸, Domestic conference

  Oral presentation


• 当科における顎関節脱臼の臨床的検討

  大槻有美, Akashi Masaya, 黄文蘇, 筧康正, Komori Takahide

  第29回日本顎関節学会総会・学術大会, Jul. 2016, Japanese, 日本顎関節学会, 箱根, Domestic conference

  Poster presentation


• 当院における過去8年間の外傷歯患者の臨床統計的検討 ～顎骨骨折の有無と外傷歯の関係について～

  可信雅彦, 筧 康正, 小守紗也華, Akashi Masaya, Furudoi Shungo, Komori Takahide

  第16回日本外傷歯学会総会・学術大会, Jul. 2016, Japanese, 日本外傷歯学会, 神戸, Domestic conference

  Oral presentation


• 造血器悪性腫瘍に対する化学療法中のD-indexと口腔内感染性合併症との関連についての検討

  Akashi Masaya, 岸本 恵実, 辻 和志, 楠元 順哉, Yakushijin Kimikazu, Kawamoto Shinichiro, 岡村 篤夫, Matsuoka Hiroshi, Furudoi Shungo, Komori Takahide

  第14回日本臨床腫瘍学会, Jul. 2016, Japanese, 日本臨床腫瘍学会, 神戸市, Domestic conference

  Oral presentation


• 全身麻酔挿管中に生じる歯の損傷も後ろ向き調査

  小守紗也華, 筧 康正, 可信雅彦, Akashi Masaya, Furudoi Shungo, Komori Takahide

  第16回日本外傷歯学会総会・学術大会, Jul. 2016, Japanese, 日本外傷歯学会, 神戸, Domestic conference

  Oral presentation


• 顎関節に生じた滑膜骨軟骨腫症の1例

  黄文蘇, Akashi Masaya, 大槻有美, 橘進彰, Komori Takahide

  第29回日本顎関節学会総会・学術大会, Jul. 2016, Japanese, 日本顎関節学会, 箱根, Domestic conference

  Poster presentation


• 下顎歯肉癌の精査においてCowden症候群の合併が示唆された1例

  榎本由依, Akashi Masaya, 平岡佑二郎, 船原隆一郎, Minamikawa Tsutomu, Komori Takahide

  第47回日本口腔外科学会近畿支部学術集会, Jul. 2016, Japanese, 日本口腔外科学会, 大阪, Domestic conference

  Oral presentation


• 下顎骨骨折の治療を行ったLennox-Gastaut症候群患児の1例

  中西洋介, Matsumoto Kousuke, 小守紗也華, Hasegawa Takumi, Akashi Masaya, 柚鳥宏和, 橘進彰, Komori Takahide

  第16回日本外傷歯学会総会・学術大会, Jul. 2016, Japanese, 日本外傷歯学会, 神戸, Domestic conference

  Oral presentation


• 15歳女児に生じた舌扁平上皮癌の1例

  綿越健太, Minamikawa Tsutomu, 寺岡 駿, Akashi Masaya, Komori Takahide

  第47回日本口腔外科学会近畿支部学術集会, Jul. 2016, Japanese, 日本口腔外科学会, 大阪, Domestic conference

  Oral presentation


• 歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価

  Akashi Masaya, Hashikawa Kazunobu, 鰐渕 聡, 楠元順哉, Hasegawa Takumi, Minamikawa Tsutomu, Terashi Hiroto, Komori Takahide

  第40回日本頭頸部癌学会総会・学術大会, Jun. 2016, Japanese, 日本頭頸部癌学会, 埼玉, Domestic conference

  Oral presentation


• 歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価

  Akashi Masaya, Hashikawa Kazunobu, 鰐渕聡, 楠元 順哉, Hasegawa Takumi, Minamikawa Tsutomu, Terashi Hiroto, Komori Takahide

  第40回日本頭頸部癌学会, Jun. 2016, Japanese, 日本頭頸部癌学会, さいたま市, Domestic conference

  Oral presentation


• 下顎枝垂直骨切り術後の骨癒合に対する低出力超音波パルス(LIPUS)の効果

  有本智美, Hasegawa Takumi, 岡本奈那, 塩屋園敦, 立石千鶴, Akashi Masaya, Suzuki Yasuaki, Furudoi Shungo, Komori Takahide

  第26回日本顎変形症学会総会・学術大会, Jun. 2016, Japanese, 日本顎変形症学会, 東京, Domestic conference

  Poster presentation


• 4D-CTによる下顎再建術後患者の咀嚼の観察

  Akashi Masaya, Hashikawa Kazunobu, 渋谷恭之, Terashi Hiroto, Komori Takahide

  第40回日本頭頸部癌学会総会・学術大会, Jun. 2016, Japanese, 日本頭頸部癌学会, 埼玉, Domestic conference

  Oral presentation


• 4D-CTによる下顎再建術後患者の咀嚼の観察

  Akashi Masaya, Hashikawa Kazunobu, 渋谷恭之, Terashi Hiroto, Komori Takahide

  第40回日本頭頸部癌学会, Jun. 2016, Japanese, 日本頭頸部癌学会, さいたま市, Domestic conference

  Oral presentation


• 放射線性顎骨鋭氏壊死症例に対する画像診断を中心とした臨床的検討

  鰐渕 聡, Akashi Masaya, 岩田英治, 楠元順哉, 松本耕佑, Minamikawa Tsutomu, Furudoi Shungo, Komori Takahide

  第70回日本口腔科学会総会・学術大会, Apr. 2016, Japanese, 日本口腔科学会, 福岡, Domestic conference

  Oral presentation


• 当科における埋伏智歯抜歯後神経系合併症に対する治療法の現状

  平岡佑二郎, Akashi Masaya, Matsumoto Kousuke, Sakakibara Akiko, 木本 明, Hasegawa Takumi, Suzuki Yasuaki, Minamikawa Tsutomu, Furudoi Shungo, Komori Takahide

  第70回日本口腔科学会総会・学術大会, Apr. 2016, Japanese, 日本口腔科学会, 福岡, Domestic conference

  Oral presentation


• 当科における歯性上顎洞炎の臨床的検討

  岩田英治, Akashi Masaya, 岸本恵実, 藤林淳子, 楠元順哉, Furudoi Shungo, Komori Takahide

  第70回日本口腔科学会総会・学術大会, Apr. 2016, Japanese, 日本口腔科学会, 福岡, Domestic conference

  Poster presentation


• 当科におけるFibro-osseous lesionsの臨床的検討

  松尾健司, Akashi Masaya, 筧 康正, Matsumoto Kousuke, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, 橘進彰, Komori Takahide

  第70回日本口腔科学会総会・学術大会, Apr. 2016, Japanese, 日本口腔科学会, 福岡, Domestic conference

  Oral presentation


• 中咽頭癌化学放射線治療患者における口腔衛生管理-強度変調放射線治療(IMRT)と従来型放射線治療(RT)の比較

  西井美佳, 筧 康正, 冨田 和, 難波 渚, 田村恵利, 澤田麻衣子, Akashi Masaya, Furudoi Shungo, Komori Takahide

  第13回日本口腔ケア学会総会・学術大会, Apr. 2016, Japanese, 日本口腔ケア学会, 千葉, Domestic conference

  Oral presentation


• 遺伝子解析により確定診断を得たMALTリンパ腫の1例

  筧 康正, Akashi Masaya, 木本 明, Hasegawa Takumi, Minamikawa Tsutomu, Komori Takahide

  第70回日本口腔科学会総会・学術大会, Apr. 2016, Japanese, 日本口腔科学会, 福岡, Domestic conference

  Oral presentation


• 腓骨皮弁採取部における一期縫縮と植皮の比較

  渡邊一博, Akashi Masaya, 楠本順哉, Matsumoto Kousuke, 木本 明, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会, 横浜, Domestic conference

  Poster presentation


• 術前18F-FDG PET/CT撮影での口腔癌原発巣における定量評価の有用性

  米澤奈津季, Minamikawa Tsutomu, 北島一宏, 高橋佑輔, 筧 康正, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会, 横浜, Domestic conference

  Poster presentation


• 口腔扁平上皮癌被膜外浸潤症例の臨床病理学的検討

  筧 康正, Minamikawa Tsutomu, 寺岡 駿, 米澤奈津季, 高橋佑輔, Hasegawa Takumi, Akashi Masaya, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会, 横浜, Domestic conference

  Poster presentation


• 口腔扁平上皮癌患者の遠位レベル（level4,5）への頸部リンパ節転移が予後に与える影響

  定兼啓倫, Hasegawa Takumi, 渋谷恭之, 米澤奈津季, 武田大介, 高橋佑輔, 筧 康正, Akashi Masaya, Minamikawa Tsutomu, Furudoi Shungo, Hashikawa Kazunobu, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会, 横浜, Domestic conference

  Poster presentation


• 口腔扁平上皮癌における外的刺激受容体（TRPVチャネル）の発現

  Sakakibara Akiko, 榊原 俊介, 楠元 順哉, 武田 大介, Hasegawa Takumi, Akashi Masaya, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会総会・学術大会, 横浜市, Domestic conference

  Oral presentation


• 口腔扁平上皮癌における外的刺激受容体(TRPVチャネル)の発現亢進

  Sakakibara Akiko, 榊原俊介, 楠元順哉, 武田大介, Hasegawa Takumi, Akashi Masaya, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会, 横浜, Domestic conference

  Poster presentation


• 局所的炭酸ガス投与による皮弁壊死抑制効果

  齊藤 泉, Hasegawa Takumi, 武田大介, 岩田英治, 有本智美, 筧康正, 高橋佑輔, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会, 横浜, Domestic conference

  Poster presentation


• 移植腓骨と下顎骨の癒合における骨膜温存の重要性（ポスター発表）

  Akashi Masaya, 筧 康正, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会, 横浜, Domestic conference

  Poster presentation


• 移植腓骨と下顎骨の癒合における骨膜温存の重要性

  Akashi Masaya, 筧 康正, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会総会・学術大会, 横浜市, Domestic conference

  Oral presentation


• 再建プレート露出に対する二期再建術前PET/CTが膿瘍の検知に有用であった1例

  松尾 健司, Akashi Masaya, 楠元 順哉, 藤林 淳子, 渡邊 一博, Minamikawa Tsutomu, Hashikawa Kazunobu, 古森 孝英

  第27回NPO法人日本口腔科学会近畿地方部会．, Nov. 2015, Japanese, 日本口腔外科学会, 大阪, Domestic conference

  Oral presentation


• 化学放射線療法による口腔粘膜炎の重症度を予測する因子についての検討

  岸本 恵実, Furudoi Shungo, 藤林 淳子, 西井 美佳, 岩田 英治, 楠元 順哉, 梶 真人, 後藤 育子, Akashi Masaya, 古森 孝英

  第24回日本口腔感染症学会総会．, Nov. 2015, Japanese, 日本口腔感染症学会, 神奈川, Domestic conference

  Oral presentation


• Targeted Disruption of JCAD/KIAA1462, a Coronary Artery Disease-associated Gene Product, Inhibits Angiogenic Processes in Vitro and in Vivo.

  Tetsuya Hara, Tomoko Monguchi, Akashi Masaya, Noriko Iwamoto, Kenta Mori, Toh Ryuji, Irino Yasuhiro, Shinohara Masakazu, Mikio Furuse, Ishida Tatsuro, Hirata Ken-ichi

  American Heart Association Scientic Session 2015., Nov. 2015, English, American Heart Association, Orlando, USA, Background: Recent genome-wide association studies newly identified the human KIAA1462 gene as a new locus for coronary artery disease. However, the function of the gene product, named JCAD (junctional protein associated with coronary artery disease), is, International conference

  Poster presentation


• 入院管理下で口腔外科小手術を施行した患者に関する臨床統計

  棚倉 万紀子, 筧 康正, Minamikawa Tsutomu, 高橋 佑輔, 米澤 奈津季, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, 古森 孝英

  第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 超音波断層法による口腔癌頸部リンパ節転移の検討

  筧 康正, Minamikawa Tsutomu, 棚倉 万紀子, 米澤 奈津季, 高橋 佑輔, 松井 太輝, Hasegawa Takumi, Akashi Masaya, 重田 崇至, 古森 孝英

  第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 進展例の放射線性顎骨壊死の外科的治療におけるPETの有用性.

  Akashi Masaya, Hashikawa Kazunobu, Minamikawa Tsutomu, Furudoi Shungo, Komori Takahide

  第60回日本口腔外科学会総会．, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 三次元実態模型を用いた手術シミュレーションー当科における最近の使用経験

  鰐渕 聡, Akashi Masaya, Hashikawa Kazunobu, 筧 康正, 松本 耕祐, Kimoto Akira, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, 古森 孝英

  第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 口腔扁平上皮癌における外的刺激受容体の発現

  Sakakibara Akiko, 楠元 順哉, Akashi Masaya, Minamikawa Tsutomu, Komori Takahide

  第60回日本口腔外科学会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 口腔癌原発巣の術前18F-FDG PET/CT撮影に関する検討

  米澤 奈津季, Minamikawa Tsutomu, 北島一宏, 高橋 佑輔, 筧 康正, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, 古森 孝英

  第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 経皮的炭酸ガス投与による口腔癌上皮間葉移行の抑制効果

  岩田 英治, Hasegawa Takumi, 武田 大介, Akashi Masaya, Minamikawa Tsutomu, 古森 孝英

  第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• ロケーター・マグネット付きカスタムバーによるインプラントオーバーデンチャー関連合併症

  有本 智美, Hasegawa Takumi, 斉藤 泉, 岩田 英治, 武田 大介, Akashi Masaya, Suzuki Yasuaki, Furudoi Shungo, 古森 孝英

  第60回日本口腔外科学会総会．, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• Observation of Mastication in Patients Underwent Mandibular Reconstruction by 4D-CT with 320 Detector-Row Scanning : A Preliminary Report,

  Akashi Masaya, Shibuya Y, Takahashi Satoru, Hashikawa Kazunobu, Hasegawa Takumi, Kakei Y, Negi N, Sekitani T, Komori Takahide

  22nd International conference on oral and maxilofacial surgery,, Oct. 2015, English, メルボルン, オーストラリア, International conference

  Oral presentation


• Incidence of venousthromboembolism after oral surgery with simultaneous reconstruction,

  Kakei Y, Akashi Masaya, Shigeta T, Takahashi Yutaka, Mastui T, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Komori Takahide

  22nd International conference on oral and maxilofacial surgery,, Oct. 2015, English, メルボルン, オーストラリア, International conference

  Oral presentation


• Evaluating the changes in the amount of bone augmentation after sinus lift using panoramic radiography: Comparison evaluations based on CT images．

  松尾 健司, Suzuki Yasuaki, 松本 耕祐, Kimoto Akira, Hasegawa Takumi, Akashi Masaya, 竹内 順一郎, 古森 孝英

  第60回日本口腔外科学会総会．, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• A novel strategy aimed at apoptosis via the mitochondrial pathway and improving hypoxia in oral squamous cell carcinoma.．

  武田 大介, Hasegawa Takumi, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, 古森 孝英

  第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 当科における下顎の骨折線上の歯に関する臨床的検討

  北山 美登里, Suzuki Yasuaki, 小守 紗也華, 松本 耕祐, Akashi Masaya, 古森 孝英

  第15回日本外傷歯学会，, Jul. 2015, Japanese, 日本外傷歯学会, 福岡, Domestic conference

  Oral presentation


• 混合歯列期の下顎骨骨折に対し非観血的整復治療を行った1例

  小守 紗也華, 松本 耕祐, 北山 美登里, Akashi Masaya, 立石 千鶴, Suzuki Yasuaki, Komori Takahide

  第15回日本外傷歯学会，, Jul. 2015, Japanese, 日本外傷歯学会, 福岡, Domestic conference

  Oral presentation


• 当院における周術期口腔機能管理に関する実態調査と今後の課題

  田村 惠利, 西井 美佳, 冨田 和, 難波 渚, Hasegawa Takumi, Akashi Masaya, Furudoi Shungo, 古森 孝英

  第12回日本口腔ケア学会総会・学術大会．, Jun. 2015, Japanese, 日本口腔ケア学会, 山口, Domestic conference

  Oral presentation


• 外科的矯正手術前後における顎関節症状および顎関節MRI画像の変化.

  定兼 啓倫, Hasegawa Takumi, 有本 智美, 岡本 奈那, 塩屋園 敦, 立石 千鶴, Akashi Masaya, Suzuki Yasuaki, Furudoi Shungo, Komori Takahide

  第25回日本顎変形症学会総会．, Jun. 2015, Japanese, 日本顎変形症学会, 東京, Domestic conference

  Oral presentation


• Sequential evaluation of bone union of transferred fibula flaps in reconstructed mandibles.

  Akashi Masaya, Hashikawa Kazunobu, Kakei Y, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Komori Takahide

  "The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, Jun. 2015, English, 神戸, Domestic conference

  Oral presentation


• Decreased mitochondrial copy numbers in oral squamous cell carcinoma.

  Takeda D, Hasegawa Takumi, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, Komori Takahide

  "The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, Jun. 2015, English, 神戸, Domestic conference

  Oral presentation


• -

  難波 渚, 西井 美佳, 冨田 和, 田村 恵利, Hasegawa Takumi, Akashi Masaya, Furudoi Shungo, 古森 孝英

  第12回日本口腔ケア学会総会・学術大会．, Jun. 2015, Japanese, 日本口腔ケア学会, 山口, Domestic conference

  Oral presentation


• 下顎骨骨髄炎との鑑別が困難であった下顎歯肉悪性腫瘍の1例

  渡邊 一博, Furudoi Shungo, 筧 康正, Akashi Masaya, Minamikawa Tsutomu, 古森 孝英

  第46回日本口腔外科学会近畿支部学術集会．, Mar. 2015, Japanese, 日本口腔外科学会, 神戸, Domestic conference

  Oral presentation


• 移植非骨と下顎骨の骨癒合に関する経時的評価－パノラマX線とCT画像の比較－

  Akashi Masaya, Hashikawa Kazunobu, Sakakibara Akiko, 楠元 順哉

  第109回関西形成外科学会地方会．, Mar. 2015, Japanese, 関西形成外科学会, 京都, Domestic conference

  Oral presentation


• 当科における頸部郭清術術後の頸部ドレーンに関する臨床的検討

  齊藤 泉, Hasegawa Takumi, 米澤 奈津季, 武田 大介, 高橋 佑輔, 筧 康正, 松井 太輝, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, 古森 孝英

  第33回日本口腔腫瘍学会, Jan. 2015, Japanese, 日本口腔腫瘍学会, 奈良, Domestic conference

  Oral presentation


• 当科における放射線性顎骨壊死に関する臨床的検討

  鰐渕 聡, Akashi Masaya, 筧 康正, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, 古森 孝英

  第33回日本口腔腫瘍学会, Jan. 2015, Japanese, 日本口腔腫瘍学会, 奈良, Domestic conference

  Oral presentation


• 当科における口腔扁平上皮癌遠隔転移例の臨床的検討とリスク因子について

  棚倉 万紀子, Hasegawa Takumi, 米澤 奈津季, 武田 大介, 高橋 佑輔, 筧 康正, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, 古森 孝英

  第33回日本口腔腫瘍学会, Jan. 2015, Japanese, 日本口腔腫瘍学会, 奈良, Domestic conference

  Oral presentation


• 口腔扁平上皮癌臨床検体におけるミトコンドリア量について

  武田 大介, Hasegawa Takumi, 今井 佑輔, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, 古森 孝英

  第33回日本口腔腫瘍学会, Jan. 2015, Japanese, 日本口腔腫瘍学会, 奈良, Domestic conference

  Poster presentation


• 口腔癌手術症例におけるmodified Glasgow Prognostic Score(mGPS)を用いた長期予後に関する検討

  平岡 佑二郎, Minamikawa Tsutomu, 米澤 奈津季, 高橋 佑輔, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, 古森 孝英

  第33回日本口腔腫瘍学会, Jan. 2015, Japanese, 日本口腔腫瘍学会, 奈良, Domestic conference

  Poster presentation


• 口腔癌原発巣におけるDual-time-point FDG PETの有用性

  米澤 奈津季, Minamikawa Tsutomu, 高橋 佑輔, 筧 康正, 松井 太輝, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, 古森 孝英

  第33回日本口腔腫瘍学会, Jan. 2015, Japanese, 日本口腔腫瘍学会, 奈良, Domestic conference

  Oral presentation


• 下顎枝垂直骨切り術後の近位骨片と下顎頭変化の評価

  有本 智美, Hasegawa Takumi, 定兼 啓倫, 岡本 奈那, 塩屋園 敦, 立石 千鶴, Akashi Masaya, Suzuki Yasuaki, Furudoi Shungo, Komori Takahide

  第25回日本顎変形症学会総会．, Jan. 2015, Japanese, 日本顎変形症学会, 東京, Domestic conference

  Oral presentation


• 放射線治療後の甲状腺機能低下による低ナトリウム血症の1例

  村田 陽太郎, Hasegawa Takumi, 八橋 明子, Akashi Masaya, Minamikawa Tsutomu, Furudoi Shungo, Komori Takahide

  第26回日本口腔科学会近畿地方部会, Dec. 2014, Japanese, 日本口腔科学会, 京都, Domestic conference

  Oral presentation


• 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価

  Akashi Masaya, Hashikawa Kazunobu, Sakakibara Akiko, 楠元 順哉

  第108回関西形成外科学会学術集会, Dec. 2014, Japanese, 関西形成外科学会, 大阪, Domestic conference

  Oral presentation


• 経口的ビタミンB12投与が著効したHUNTER舌炎の1例

  中田 和甫史, 若林 玲奈, Akashi Masaya, Komori Takahide

  第26回日本口腔科学会近畿地方部会, Dec. 2014, Japanese, 日本口腔科学会, 京都, Domestic conference

  Oral presentation


• 当科における広範囲顎骨支持型インプラント補綴の臨床統計的検討

  今井 佑輔, Hasegawa Takumi, 川畑 真哉, 武田 大介, Akashi Masaya, Suzuki Yasuaki, Komori Takahide

  第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference

  Oral presentation


• 当科におけるインプラント242例907本埋入に関する臨床的検討

  川畑 真哉, Hasegawa Takumi, 今井 佑輔, Kimoto Akira, Akashi Masaya, Suzuki Yasuaki, Komori Takahide

  第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference

  Oral presentation


• 著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った症例

  榎本 由依, Suzuki Yasuaki, Kimoto Akira, Hasegawa Takumi, Akashi Masaya, 竹内 純一郎, Komori Takahide

  第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference

  Oral presentation


• 小児の顔面多発骨折症例の経験

  大﨑 健夫, 川北 育子, 北野 豊明, 桒水流 健二, Akashi Masaya

  第32回日本頭蓋顎顔面外科学会学術集会, Nov. 2014, Japanese, 日本頭蓋顎顔面外科学会, 大阪, Domestic conference

  Oral presentation


• 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価

  Akashi Masaya, Shibuya Yasuyuki, 鰐渕 聡, Kimoto Akira, Hasegawa Takumi, Suzuki Yasuaki, Komori Takahide

  第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference

  Oral presentation


• 入院加療を要した口腔頸部の重症感染症例の検討

  藤林 淳子, Furudoi Shungo, 畑 みどり, 楠元 順哉, 後藤 育子, Akashi Masaya, Komori Takahide

  第23回日本口腔感染症学会総会, Oct. 2014, Japanese, 日本口腔感染症学会, 伊丹, Domestic conference

  Oral presentation


• 頭頸部領域における壊死性筋膜炎に対するLRINECスコアの有用性の検討

  楠元 順哉, Furudoi Shungo, Akashi Masaya, Sakakibara Akiko, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 当科における口腔癌患者の術後せん妄に関する臨床的検討

  齊藤 泉, Hasegawa Takumi, 米澤 奈津季, 高橋 佑輔, 筧 康正, 松井 太輝, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 当院における心臓血管外科患者における周術期口腔機能管理

  藤 大補, Akashi Masaya, Furudoi Shungo, 西井 美佳, 後藤 育子, Komori Takahide

  第23回日本口腔感染症学会総会, Oct. 2014, Japanese, 日本口腔感染症学会, 伊丹, Domestic conference

  Oral presentation


• 低出力超音波パルスの下顎骨骨折血腫細胞のBMP発現における効果

  黄 文蘇, Hasegawa Takumi, 今井 佑輔, 武田 大介, Akashi Masaya, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 上顎部分切除後の遊離前腕皮弁再建群と非再建群の比較

  Akashi Masaya, Shibuya Yasuyuki, 楠元 順哉, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, Hashikawa Kazunobu, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 抗RANKLモノクローナル抗体（デノスマブ）に発症した顎骨壊死の1例

  岩田 英治, Akashi Masaya, Hasegawa Takumi, Furudoi Shungo, Komori Takahide

  第23回日本口腔感染症学会総会, Oct. 2014, Japanese, 日本口腔感染症学会, 伊丹, Domestic conference

  Oral presentation


• 口腔扁平上皮癌N0症例への予防的頸部郭清の検討：T1-2とT3-4の比較

  八橋 明子, Minamikawa Tsutomu, 松井 太輝, 高橋 佑輔, 米澤 奈津季, 筧 康正, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 口腔癌手術における輸血療法の現状

  米澤 奈津季, Minamikawa Tsutomu, 高橋 佑輔, 筧 康正, 松井 太輝, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, Shibuya Yasuyuki, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 口腔癌に対する救済手術についての検討

  筧 康正, Minamikawa Tsutomu, 米澤 奈津季, 高橋 佑輔, 松井 太輝, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, Shibuya Yasuyuki, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 局所的炭酸ガス投与による口腔癌新規治療法の開発

  武田 大介, Hasegawa Takumi, 今井 佑輔, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, Shibuya Yasuyuki, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 化学放射線療法中の中咽頭癌患者における口腔乾燥の経時的変化

  西井 美佳, Akashi Masaya, 筧 康正, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• フェーズラグCT（pl-CTA）による顎骨周囲の脈管の評価

  Sakakibara Akiko, Sakakibara Shunsuke, Hasegawa Takumi, Akashi Masaya

  第59回日本口腔外科学会総会・学術集会, Oct. 2014, Japanese, 日本口腔外科学会, 幕張, Domestic conference

  Oral presentation


• フェーズラグCTA（ｐｌ－CTA）による顎動静脈分岐の評価

  Sakakibara Akiko, Sakakibara Shunsuke, 楠元 順哉, Hasegawa Takumi, Akashi Masaya, Suzuki Yasuaki, Minamikawa Tsutomu, Furudoi Shungo, Hashikawa Kazunobu, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• ビスフォスフォネート関連顎骨壊死症例のCT画像における臨床的検討

  岩田 英治, Akashi Masaya, 楠元 順哉, Hasegawa Takumi, 後藤 育子, Furudoi Shungo, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 対側オトガイ部の知覚異常を初発症状としたびまん性大細胞型B細胞性リンパ腫の1例

  高端 大希, Akashi Masaya, 高橋 佑輔, 辻 和志, 西尾 良介, Minamikawa Tsutomu, Komori Takahide

  第45回日本口腔外科学会近畿地方会, Jun. 2014, Japanese, 日本口腔外科学会, 奈良, Domestic conference

  Oral presentation


• 口腔癌再建術後の感染性合併症－術後CRPのabnormal responseに注目して－

  Akashi Masaya, Hashikawa Kazunobu, Minamikawa Tsutomu, Shibuya Yasuyuki, Komori Takahide

  第38回日本頭頸部癌学会, Jun. 2014, Japanese, 日本頭頸部癌学会, 東京, Domestic conference

  Oral presentation


• 顎関節部に限局する線維-骨性病変の1例

  八橋 明子, Shibuya Yasuyuki, 後藤 育子, Akashi Masaya, 松井 太輝, Komori Takahide

  第45回日本口腔外科学会近畿地方会, Jun. 2014, Japanese, 日本口腔外科学会, 奈良, Domestic conference

  Oral presentation


• 過去15年間の高齢口腔癌患者に関する臨床的検討

  米澤 奈津季, Minamikawa Tsutomu, 高橋 佑輔, Akashi Masaya, Shibuya Yasuyuki, Komori Takahide

  第38回日本頭頸部癌学会, Jun. 2014, Japanese, 日本頭頸部癌学会, 東京, Domestic conference

  Oral presentation


• 栄養・輸液サポートチームにおける歯科的介入について

  若林 玲奈, Shibuya Yasuyuki, 今井 佑輔, 黒木 信祐, 後藤 育子, Akashi Masaya, Furudoi Shungo, Komori Takahide

  第45回日本口腔外科学会近畿地方会, Jun. 2014, Japanese, 日本口腔外科学会, 奈良, Domestic conference

  Oral presentation


• 造血気悪性腫瘍患者への歯科的介入に関する前向き検討

  辻 和志, Shibuya Yasuyuki, 岸本 恵実, 棚倉 万紀子, Akashi Masaya, Furudoi Shungo, Komori Takahide

  第68回日本口腔科学会学術総会, May 2014, Japanese, 日本口腔科学会, 東京, Domestic conference

  Oral presentation


• 口腔内細菌数が放射線性口腔粘膜炎に及ぼす影響について

  後藤 育子, Furudoi Shungo, 西井 美佳, 楠本 順哉, 梶 真人, Akashi Masaya, Komori Takahide

  第68回日本口腔科学会学術総会, May 2014, Japanese, 日本口腔科学会, 東京, Domestic conference

  Poster presentation


• 口腔癌再建術後の頸部感染評価目的でのCTの有用性

  Akashi Masaya, Furudoi Shungo, Minamikawa Tsutomu, Kimoto Akira, Sakakibara Akiko, Hasegawa Takumi, 後藤 育子, Shibuya Yasuyuki, Komori Takahide

  第68回日本口腔科学会学術総会, May 2014, Japanese, 日本口腔科学会, 東京, Domestic conference

  Oral presentation


• Preformed Reconstruction plateで下顎再建を行った2症例

  竹内 惇平, Furudoi Shungo, 藤 大補, 高橋 佑輔, Akashi Masaya, Sakakibara Akiko, Minamikawa Tsutomu, Shibuya Yasuyuki, Komori Takahide

  第68回日本口腔科学会学術総会, May 2014, Japanese, 日本口腔科学会, 東京, Domestic conference

  Oral presentation


• パネルディスカッション3. ビデオで伝えたい私の手順

  Nomura Tadashi, Sakakibara Shunsuke, Takasu Hiroyuki, Akashi Masaya, Hashikawa Kazunobu, 田原 真也, Terashi Hiroto

  第19回日本形成外科手術手技学会, Feb. 2014, Japanese, 日本形成外科手術手技学会, 愛知, Domestic conference

  Public discourse


• 高齢口腔癌患者に関する臨床的検討

  米澤 奈津季, Minamikawa Tsutomu, Akashi Masaya, 高橋 佑輔, 重田 崇至, Shibuya Yasuyuki, Komori Takahide

  第32回日本口腔腫瘍学会, Jan. 2014, Japanese, 日本口腔腫瘍学会, 札幌, Domestic conference

  Oral presentation


• 口腔癌cN1症例に対する頸部郭清術の廓清範囲についての検討

  筧 康正, Minamikawa Tsutomu, 高橋 佑輔, 松井 太輝, Hasegawa Takumi, Akashi Masaya, 重田 崇至, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  第32回日本口腔腫瘍学会, Jan. 2014, Japanese, 日本口腔腫瘍学会, 札幌, Domestic conference

  Oral presentation


• 遊離腓骨皮弁移植におけるMR Angiographyによる下肢血管解剖の術前評価

  楠元 順哉, 橋川 和信, Akashi Masaya, 榊原 晶子, Terashi Hiroto

  第105回日本形成外科学会関西支部学術集会, Dec. 2013, Japanese, 本形成外科学会, 大阪, Domestic conference

  Oral presentation


• 口腔外に肉芽形成をきたしたビスフォスフォネート関連顎骨壊死の1例

  岩田英治, Furudoi Shungo, 楠元順哉, 後藤育子, Akashi Masaya, Komori Takahide

  第25回日本口腔科学会近畿地方部会, Dec. 2013, Japanese, 日本口腔科学会, 大阪, Domestic conference

  Oral presentation


• 胃癌術後の腹壁再発切除術により生じた 胸腹壁欠損に対する治療経験

  長谷川 泰子, Nomura Tadashi, Akashi Masaya, 前田 翔, 橋川 和信, Terashi Hiroto

  第105回関西形成外科学会学術集会, Dec. 2013, Japanese, 関西形成外科学会学術集会, 大阪市, Domestic conference

  Oral presentation


• 片側性唇顎口蓋裂を伴う咬合不全に対し腓骨皮弁による骨再建とインプラント埋入術を行った成人男性の1例

  齊藤 泉, Shibuya Yasuyuki, 筧 康正, Akashi Masaya, Shigeta Takashi, Komori Takahide

  第17回顎顔面インプラント学会総会, Nov. 2013, Japanese, 顎顔面インプラント学会, 東京, Domestic conference

  Oral presentation


• 当科における重症性感染症例の臨床的検討

  藤林淳子, Furudoi Shungo, 小松原秀紀, 楠元順哉, 後藤育子, Akashi Masaya, Komori Takahide

  第22回口腔感染症学会総会, Nov. 2013, Japanese, 口腔感染症学会, 八王子, Domestic conference

  Oral presentation


• 呼吸サポートチームへの歯科介入がVAP予防に与える影響について

  後藤育子, Furudoi Shungo, 西井美佳, 四宮麻美, 楠元順哉, 梶 真人, Akashi Masaya, Shibuya Yasuyuki, Komori Takahide

  第22回口腔感染症学会総会, Nov. 2013, Japanese, 口腔感染症学会, 八王子, Domestic conference

  Oral presentation


• 超高純度マグネシウムを用いて生体吸収性金属製骨接合プレートを作製する

  橋川 和信, Takasu Hiroyuki, Akashi Masaya, Terashi Hiroto

  第31回日本頭蓋顎顔面外科学会学術集会, Oct. 2013, Japanese, 日本頭蓋顎顔面外科学会学術集会, 名古屋市, Domestic conference

  Oral presentation


• 舌半側切除後の遊離前腕皮弁再建症例における長期観察結果．

  Akashi Masaya, 橋川 和信, 榊原 晶子, Hasegawa Takumi, Shigeta Takashi, Minamikawa Tsutomu, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  第58回日本口腔外科学会総会・学術大会, Oct. 2013, Japanese, 日本口腔外科学会総会・学術大会, 福岡市, Domestic conference

  Oral presentation


• 口腔癌患者における胃瘻造設に関する検討―術中同時胃瘻造設について-

  米澤奈津季, Minamikawa Tsutomu, Akashi Masaya, 高橋佑輔, Hasegawa Takumi, 榊原晶子, Shigeta Takashi, Shibuya Yasuyuki, Komori Takahide

  第58回日本口腔外科学会総会, Oct. 2013, Japanese, 日本口腔外科学会, 福岡, Domestic conference

  Oral presentation


• 口腔癌における周術期静脈血栓塞栓症について

  筧 康正, Minamikawa Tsutomu, 高橋佑輔, 松井太輝, 榊原晶子, Akashi Masaya, Shigeta Takashi, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  第58回日本口腔外科学会総会, Oct. 2013, Japanese, 日本口腔外科学会, 福岡, Domestic conference

  Oral presentation


• シスプラチン併用化学放射線療法の術後補助療法としての有効性に関する検討

  Shigeta Takashi, Minamikawa Tsutomu, 松井太輝, Akashi Masaya, Hasegawa Takumi, 高橋佑輔, 筧 康正, Shibuya Yasuyuki, 梅田正博, Komori Takahide

  第58回日本口腔外科学会総会, Oct. 2013, Japanese, 日本口腔外科学会, 福岡, Domestic conference

  Oral presentation


• 再発口腔中咽頭癌に対する遊離皮弁再建に関する検討．

  Akashi Masaya, 橋川 和信, Terashi Hiroto

  第40回日本マイクロサージャリー学会学術集会, Sep. 2013, Japanese, 日本マイクロサージャリー学会学術集会, 盛岡市, Domestic conference

  Oral presentation


• 再発口腔中咽頭癌に対する遊離皮弁再建における問題点-第2報-

  Akashi Masaya, 橋川和信, Terashi Hiroto

  第40回日本マイクロサージェリー学会総会, Sep. 2013, Japanese, 日本マイクロサージェリー学会, 岩手, Domestic conference

  Oral presentation


• 舌半側切除後の遊離前腕皮弁再建症例における長期観察結果．

  Akashi Masaya, 橋川 和信, 榊原 晶子, Terashi Hiroto

  第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 東京都, Domestic conference

  Oral presentation


• 再発口腔中咽頭癌に対する遊離皮弁再建における問題点

  Akashi Masaya, 橋川 和信, Terashi Hiroto

  第37回日本頭頸部癌学会総会, Jun. 2013, Japanese, 日本頭頸部癌学会, 東京, Domestic conference

  Oral presentation


• がん切除後下顎再建における再建理論「CATコンセプト」．

  橋川 和信, Akashi Masaya, Nomura Tadashi, Terashi Hiroto

  第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 東京都, Domestic conference

  Oral presentation


• 造血器悪性腫瘍患者への歯科的介入に関する前向き検討

  辻 和志, Shibuya Yasuyuki, Akashi Masaya, Furudoi Shungo, Komori Takahide

  第67回日本口腔科学会総会, May 2013, Japanese, 日本口腔科学会, 宇都宮, Domestic conference

  Oral presentation


• 放射線誘発癌が疑われた口腔癌に対する遊離皮弁再建

  Akashi Masaya, 橋川 和信, Terashi Hiroto

  第103回関西形成外科学会学術集会, Mar. 2013, Japanese, 関西形成外科学会学術集会, 大阪市, Domestic conference

  Oral presentation


• 舌癌180例のリンパ節転移に関する検討～健側転移について～

  松井太輝, Shigeta Takashi, Minamikawa Tsutomu, Akashi Masaya, 高橋佑輔, 筧 康正, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  第31回日本口腔腫瘍学会総会, Jan. 2013, Japanese, 日本口腔腫瘍学会, 東京, Domestic conference

  Oral presentation


• 口腔扁平上皮癌術後局所再発症例に関する検討

  高橋佑輔, Minamikawa Tsutomu, 筧 康正, 松井太輝, 榊原晶子, Akashi Masaya, Shigeta Takashi, Shibuya Yasuyuki, Komori Takahide

  第31回日本口腔腫瘍学会総会, Jan. 2013, Japanese, 日本口腔腫瘍学会, 東京, Domestic conference

  Oral presentation


• 口腔扁平上皮癌T4症例に対する手術療法の治療成績

  筧 康正, Minamikawa Tsutomu, 高橋佑輔, 松井太輝, 榊原晶子, Akashi Masaya, Shigeta Takashi, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  第31回日本口腔腫瘍学会総会, Jan. 2013, Japanese, 日本口腔腫瘍学会, 東京, Domestic conference

  Oral presentation


• Facial artery musculomucosal flapにより口腔上顎洞瘻孔を治療した1例

  Akashi Masaya, 橋川 和信, Sakurai Sayuri, Terashi Hiroto

  第30回日本頭蓋顎顔面外科学会学術集会, Nov. 2012, Japanese, 日本頭蓋顎顔面外科学会, 豊中, Domestic conference

  Oral presentation


• 遊離腓骨皮弁移植におけるMR Angiographyと超音波検査による下肢血管解剖の術前評価

  Akashi Masaya, 橋川 和信, 榊原 晶子, Hasegawa Takumi, Shigeta Takashi, Minamikawa Tsutomu, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  第57回日本口腔外科学会総会・学術大会, Oct. 2012, Japanese, 日本口腔外科学会, 横浜, Domestic conference

  Oral presentation


• 下顎骨区域欠損に対する再建理論「CATコンセプト」の実践

  橋川 和信, Akashi Masaya, 榊原 晶子

  第57回日本口腔外科学会総会・学術大会, Oct. 2012, Japanese, 日本口腔外科学会, 横浜, Domestic conference

  Oral presentation


• 外傷後に生じたclaw toe変形に対し長趾屈筋移行術を施行した1例

  Takasu Hiroyuki, 橋川 和信, Akashi Masaya, Terashi Hiroto

  第101回日本形成外科学会関西支部学術集会, Jul. 2012, Japanese, 日本形成外科学会関西支部, 大阪, Domestic conference

  Oral presentation


• 金属製再建プレートによる下顎骨再建後の合併症について－下顎骨硬性再建に関する一考察

  Akashi Masaya, 橋川 和信, 榊原 晶子, Sakakibara Shunsuke, 横尾 聡, Terashi Hiroto, 田原 真也

  第55回日本形成外科学会総会・学術集会, Apr. 2012, Japanese, 日本形成外科学会, 東京, Domestic conference

  Oral presentation


• プレート破折後に遊離腓骨皮弁で下顎骨再建を行った1例

  Akashi Masaya, Hashikawa Kazunobu, 田原 真也

  第99回日本形成外科学会 関西支部学術集会, Dec. 2011, Japanese, 日本形成外科学会, 京都, Domestic conference

  Oral presentation


• Protective immune response by intranasal immunization with split-virion influenza A vaccine with adjuvant and whole-viron influenza A vaccine

  Okamoto S, Matsuoka Shozo, Yamada Hideto, Gomi Y, Okuno Y, Akagi T, Akashi Masaya, Mori Yasuko, Yamanishi K

  Cell Symposia: Influenza - Translating basic insights, Dec. 2010, English, Elsevier(Cell Press), Washington DC, アメリカ合衆国, International conference

  Oral presentation


• Impaired stratum corneum formation in claudin-1-deficient mice with defect in tight junction function

  Sugawara T, Akashi Masaya, Yuki T, Nakagawa N, Sakai S, Sugiyama Y, Inoue S, Furuse Mikio

  第35回日本研究皮膚科学会総会, Dec. 2010, English, 日本研究皮膚科学会, 和歌山, Domestic conference

  Oral presentation


• 口腔癌手術における嚥下改善手術に関する臨床的検討．

  Akashi Masaya, Minamikawa Tsutomu, 高橋英哲, 小國 晶子, Hashikawa Kazunobu, Furudoi Shungo, Shibuya Yasuyuki, 梅田 正博, Komori Takahide

  第55回日本口腔外科学会総会, Oct. 2010, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation

• 好中球に着眼したシェーグレン症候群の新規病理分類提案と治療薬探索

  後藤 育子, 西村 啓佑, 重岡 学, 木本 明, 明石 昌也, 明石 健吾, 筧 康正

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2023 - 31 Mar. 2026


• 顎骨壊死に対する腐骨分離促進療法の探索

  明石 昌也, 重岡 学, 有本 智美, 木本 明, 長谷川 巧実, 筧 康正

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2023 - 31 Mar. 2026


• ミトコンドリアの正常化と癌関連線維芽細胞の再教育を目指した新規口腔癌治療法の開発

  長谷川 巧実, 榊原 晶子, 明石 昌也, 武田 大介

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2022 - 31 Mar. 2026


• 統合オミックス解析による口腔がん制御機構の解明と創薬標的の網羅的探索

  木本 明, 明石 昌也, 榎本 由依

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2021 - 31 Mar. 2024

  口腔がんの大部分は扁平上皮癌であり、標準的治療は手術とされている。また、補助療法として放射線治療、化学療法が併用されることが多いが、進行がんに対しては予後が悪く、制御が可能であった場合でも患者自身のQOLを著しく低下させる。そのため、根治治療を目的としながらも、可能な限り機能を温存することも口腔がんにおいては重要である。現在、口腔がんに対する化学療法は、シスプラチン(CDDP)や5-FU、ドセタキセルが使用されている。しかし、進行がんを制御するまでは至っておらず、副作用も多い。本研究では、統合オミックス解析を行い、口腔がんに特異的な代謝経路を探索する。また、それに関わる代謝酵素のうち、がんの増殖の制御に関わるものを導き出し、その阻害剤の効果を検討することで、将来的な口腔がんの新たな治療薬の開発をめざす。 今年度は、まずヒト由来口腔がん細胞株（OSC-19、HSC-3）のガスクロマトグラフィー質量分析を実施した。また、口腔がん患者の血漿メタボローム解析を実施し、得られたデータを統計ソフトを用いて多変量解析することで、口腔がん患者に特異的な代謝物の変動を探索している。次に、ヒト由来口腔がん細胞株と血漿メタボローム解析の結果と比較することで、特に著明な変化を示す代謝経路の探索を開始している。今後は、これらに加え、口腔がん生体材料のメタボローム解析を実施することで、さらに口腔がん特異的な代謝経路を絞っていく予定である。


• Development of a new evaluation method for chewing function applying basic food science and its ripple effect on oral flail

  渋谷 恭之, 高岡 素子, 桐田 忠昭, 梅田 正博, 栗田 浩, 明石 昌也, 前田 道徳

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Nagoya City University, 01 Apr. 2020 - 31 Mar. 2024

  総義歯装着者や口腔外科等で顎骨切除した患者等に対して咀嚼機能を評価することは、総義歯の調整を行ったり、術後の経過を評価したり、術後の食事ケアの内容を決定したりするうえで極めて重要である。また、オーラルフレイルのある高齢者に提供する栄養学的に適切な食事メニューを決めるためにも、咀嚼機能の評価は必要である。従来の咀嚼機能評価としては、佐藤らの総義歯咀嚼能率判定表が良く用いられている。この判定法は、総義歯装着者に対して100種類の食品について咀嚼に関するアンケート調査を行った結果に基づき、各食品の咀嚼難易度を咀嚼指数を定めた表によって咀嚼機能が評価される。このため、各食材を用いることにより簡便に咀嚼機能を評価することができる。しかしながら、総義歯装着者に対するアンケートという主観的な調査方法に基づいているため客観性に乏しく、咀嚼難易度の判定基準が不明確であるという問題があった。また、食品の調理方法や形態についても定められておらず、曖昧であるという問題もあった。さらには、食生活の変化により、現代ではあまり食されていないという食品も多く含まれているという問題があった。そこで総義歯咀嚼能率判定表に示された数多くの食材について物理的特性を測定機器を用いて解析し、総義歯咀嚼能率判定表における咀嚼指数との相関関係を調べた。その結果、測定値から得られた５つのパラメータ（硬さ、粘着性、付着性、凝集性及び咀嚼性）のうち咀嚼性のみが咀嚼指数との間で有意な相関関係を示すことを見出した。さらに、咀嚼性を決定するパラメータのうち、硬さ及び凝集性の値によってクラスター分析を行ったところ、判定基準が明確で客観性を有するいくつかのクラスターに分類できることを明らかとなった。これを指標に試料となるグミを開発中である。


• Development of treatment system for periodontal disease and oral cancer using bio-compatible titanium dioxide

  荻野 千秋, 明石 昌也, 西村 勇哉, 筧 康正

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Kobe University, 09 Jul. 2021 - 31 Mar. 2023

  近年、口腔がんと口腔細菌叢（歯周病菌叢）との関連を示唆する科学的根拠が報告され、注目を集めている(Scientific Reports, 7, 11773 (2017)など)。本研究の目的は、口腔がん、および歯周病の原因となる歯周病菌叢に対して、同一手法で治療する方法を提案する。具体的には、我々が構築した「過酸化チタン粒子」(TiOx)の酸化力、およびその放射線照射法の適用性を適用・検証する事である。本研究の目的は、「過酸化チタン／放射線」照射法を、口腔がんや歯周病菌叢へと適用し、少ない放射線量においてもがん細胞、および細菌損傷に適用可能か検証を行う事である。この研究目的の遂行のために、以下に掲げる2つの項目について検討を行った。 [1] 植物成分でコーティングされた過酸化チタン粒子の開発：TiO2 NPs(石原産業)を元に、RutinG-TiOx NPsと、PAA-TiOx NPsにRutinGを添加したRutinG+PAA-TiOx NPsを作製した。各修飾粒子をUV-visとFT-IRによって、RuitnGのコーティングを確認した。PAA-TiOx NPsと比較したRutinG-TiOxの放射線増感効果の検証するために、H2O2の吸脱着量を化学蛍光法によって定量した。PAA-TiOx及びRutinG-TiOx NPsから219.8, 39.5 micro-mol/gのH2O2が脱着した。この結果より、RutinG-TiOxはPAA-TiOxほどではないがH2O2徐放性を持つことが示唆された。 [2] 過酸化チタン/放射線による治療：in vitroでの放射線増感効果を検証するためコロニーアッセイを行った。5Gyを照射した場合、RutinG-TiOx NPsにもPAA-TiOx NPsと同様に放射線増感効果を持つことが示された。


• 血管・リンパ管新生に着眼した歯性感染症－顎骨骨髄炎移行メカニズム解明と治療法探索

  明石 昌也, 木本 明, 長谷川 巧実, 筧 康正

  日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2019 - 31 Mar. 2023

  骨粗鬆症などに対し用いられる骨吸収抑制薬や、口腔癌に対し施行される放射線照射等の医療行為が素因となる顎骨骨髄炎は、近年患者数の増加に伴い顎口腔外科領域において最も新たな治療法開発が期待される難治性疾患の一つである。本研究の目的は、近年感染の進展にも関与していることが明らかとなりつつある血管・リンパ管新生をターゲットとし、歯性感染症－顎骨骨髄炎移行メカニズムを解明することである。 研究の端緒として、まず血管新生のマーカーとなりうる分子の検討を行なった。近年動脈硬化や高血圧、腫瘍の増大における病的な状態における血管新生に関与している可能性が示唆されている血管内皮細胞間接着複合体構成分子に注目した。この分子についてはマウスやヒト培養細胞を用いた研究はこれまでに行われてきたが、ヒトの組織内での発現や局在部位を確認した報告は稀少であった。当該年度の研究結果より、この分子がヒトの組織内でも特に非炎症部位の血管に比べ炎症部位の微小血管等に発現が強く、病的な血管のマーカーとなり得る可能性が示唆された。


• Development of cancer therapies to improve resistance and reduce side effects

  Hasegawa Takumi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2018 - 31 Mar. 2022

  In the present study, the combination of transcutaneous CO2 and radiation therapy significantly inhibited tumor growth compared with other treatments using a local carbon dioxide gas administration method. In the combination group, anti-human ROS modulator 1 and caspase8 were increased by radiation therapy (RT), and mitochondrial apoptosis (PARP, caspase 3, 9) were increased by transcutaneous CO2 therapy. These results indicated that transcutaneous CO2 could potentially improve the antitumor effect of RT by decreasing the intratumoral hypoxia and increasing the mitochondrial apoptosis. Our findings indicated that CO2 therapy may be a novel adjuvant therapy in combination with RT for OSCC.

  Competitive research funding


• Low-level laser therapy: A novel therapy for ARONJ with metabolomic analysis

  Hiroaki Suzuki

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2017 - 31 Mar. 2021

  For the treatment of anti-resorptive agents-related osteonecrosis of the jaw, Low reactive Level Laser Therapy is indicated overseas than before. In recent years, Low reactive Level Laser Therapy has been recognized as Low reactive Level Light Therapy including light sources such as LEDs in addition to lasers, and this research was started to find out the effectiveness of LED light for anti-resorptive agents-related osteonecrosis. The effect of LED irradiation on the indigenous bacteria in the cultured oral cavity was analyzed. Streptococcus salivarius was irradiated at wavelengths of 405, 630, and 950 nm, and the number of viable bacteria in the LED-irradiated group and the LED-non-irradiated group (control group) was compared, and a decrease in the viable cell count in the LED-irradiated group was observed.


• Myofunction MRI analysis of the oral cancer reconstruction case

  FURUDOI SHUNGO

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2017 - 31 Mar. 2020

  Skeletal muscle functional magnetic resonance image (muscle functional Magnetic Resonance Image: mfMRI) using a functional image, the change in T2 value before and after exercise for chewing muscle at rest and chewing in healthy subjects (ΔT2) was measured, ΔT2 increase in bilateral masseter during chewing was confirmed. Morphological standardization of masticatory muscles has become possible. Subsequently, when applying mfMRI to oral cancer reconstruction patients, the health side is maintained the same form and muscle mass as before surgery, chewing force was considered to be maintained. On the other hand, since the resection side is excised by surgery, the morphology is changed muscle mass has been reduced, chewing force has been suggested to be reduced.

  Competitive research funding


• メタボローム解析を用いたARONJに対する新規LED治療の開発

  鈴木 泰明

  学術研究助成基金助成金／基盤研究(C), Apr. 2017 - Mar. 2020

  Competitive research funding


• Analysis of characteristics of lymphatic microcirculation within metastatic lymph nodes focusing on endothelial cell junctional complex

  Akashi Masaya

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Kobe University, 01 Apr. 2015 - 31 Mar. 2019, Principal investigator

  The effects of radiation on morphology, cell integrity, and permeability of lymphatic endothelial cells were analyzed for a better understanding of relationship between cancer and lymphatic vessels. As a result, changes in lymphatic endothelium were found under the influence of radiation, which could contribute to an understanding of the onset mechanism of complications such as lymph node metastasis of cancer and lymphedema after radiation.

  Competitive research funding


• Characterization of junctional complex of lymphatic endothelial cells in caner lymphangiogenesis

  AKASHI Masaya

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Kobe University, 28 Apr. 2011 - 31 Mar. 2015, Principal investigator

  To maintain normal function, the lymphatic endothelium is regulated by cell-cell junctions. One of objectives of this study was to characterize cell junctions in lymphatic endothelial cells and to investigate the effects of the inflammatory cytokine TNF-α on altered cell-cell junctions. Cultured human dermal lymphatic endothelial cells (HDLEC) were immunostained with the tight junction marker, and adherens junction markers, VE-cadherin. In TNF-α-treated HDLEC, we evaluated changes in endothelial cell junctions by immunostaining and through the use of transendothelial electrical resistance (TER). The results revealed a heterogeneous distribution of cell junctions in HDLEC involving continuous and discontinuous junctions. Our data also suggest that TNF-α alters the normal distribution of cell junctions and affects the endothelial barrier of cultured lymphatic endothelial cells.

  Competitive research funding