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MATSUMIYA WataruGraduate School of Medicine / Faculty of Medical SciencesAssistant Professor
Research activity information
■ Paper- Nov. 2014, Clin Ophthalmol, 8, 2301 - 5, EnglishEfficacy and visual prognostic factors of intravitreal bevacizumab as needed for macular edema secondary to central retinal vein occlusion[Refereed]Research institution
- Apr. 2014, Pharmacogenomics, 15(6) (6), 833 - 43, EnglishEvaluation of clinical and genetic indicators for the early response to intravitreal ranibizumab in exudative age-related macular degeneration[Refereed]Scientific journal
- 2014, Ophthalmologica, 232(3) (3), 170 - 8, EnglishEvaluating dissociated optic nerve fiber layer appearance using en face layer imaging produced by optical coherence tomography[Refereed]Scientific journal
- PURPOSE: To investigate the effects of reproducibility of optical coherence tomography (OCT) measurements and imaging alignment on predictive performance for visual outcome following macular hole (MH) surgery. METHODS: We retrospectively reviewed 50 eyes that underwent MH surgery. Preoperative cross-sectional images through the center of the MH (on-center image) and through an off-center point (off-center image) were obtained from the OCT data. In each image, the following OCT parameters were either measured or calculated: minimum diameter, base diameter, hole height, temporal and nasal arm length, photoreceptor inner segment/outer segment (IS/OS) defect length, the hole form factor, the macular hole index and the tractional hole index. The IS/OS defect area was also measured. RESULTS: The reproducibility of OCT parameter values was moderate to high, and there was a significant difference in the mean measurement values between the on- and off-center images. Predictive values varied between sessions and raters, and only the preoperative photoreceptor IS/OS defect length consistently showed significant correlation with postoperative visual outcome. CONCLUSIONS: Both the reproducibility and imaging alignment might affect the predictive performance of the OCT parameter for postoperative visual outcome following MH surgery. The preoperative photoreceptor IS/OS defect length seems to be the most useful parameter in this regard.May 2013, Japanese journal of ophthalmology, 57(3) (3), 308 - 15, English, Domestic magazine[Refereed]Scientific journal
- Apr. 2013, BMC Ophthalmol, 13, 10, EnglishEffectiveness of intravitreal ranibizumab in exudative age-related macular degeneration (AMD): comparison between typical neovascular AMD and polypoidal choroidal vasculopathy over a 1 year follow-up[Refereed]Scientific journal
- PURPOSE: Multidrug resistance protein 4 (MRP4) effluxes a wide variety of endogenous compounds, including cyclic adenosine monophosphate (cAMP), and is exclusively expressed in vascular endothelial cells (ECs) of the retina. This study aimed to investigate the role of MRP4 in retinal vascular development. METHODS: The retinal vascular phenotype of Mrp4(-/-) mice was examined by whole-mount immunohistochemistry at P3, P6, and P14. The retinas from P6 pups that received an intraperitoneal injection of either solvent control or forskolin, an inducer of intracellular cAMP formation, at P4 and P5 were analyzed in terms of their vascular formation (vascular length, vascular branching, vascular density, and the number of tip cells), cell proliferation and apoptosis, and vessel stability. RESULTS: The Mrp4(-/-) mice exhibited no overt abnormalities in the development of the retinal vasculature, but retinal vascular development in the Mrp4(-/-) mice was suppressed in response to forskolin administration. There was a significant decrease in the vascular length, vascular branching, and vascular density, and inhibited tip cell formation at the vascular front. The forskolin-treated Mrp4(-/-) mice showed an increased number of Ki67-positive and cleaved caspase 3-positive ECs, a significant decrease in the amount of pericyte coverage, and a reduced number of empty sleeves. In pups exposed to hyperoxia (75% oxygen) from P7 to P12, the Mrp4(-/-) mice showed a significant increase in the unvascularized retinal area. CONCLUSIONS: Mrp4(-/-) mice exhibited suppressed retinal vascular development in response to forskolin treatment. Thus, Mrp4 might have protective roles in retinal vascular development by regulating the intracellular cAMP level.Dec. 2012, Investigative ophthalmology & visual science, 53(13) (13), 8029 - 35, English, International magazine[Refereed]Scientific journal
- Oct. 2012, 眼科臨床紀要, 5(10号) (10号), 984, Japanese在胎38週出生の胎児仮死に対する高濃度酸素管理後に重度の未熟児網膜症を呈した1例Research society
- May 2012, Japanese journal of ophthalmology, 56(3) (3), 268 - 75, EnglishSweet's syndrome with panuveitis resembling Behçet's disease[Refereed]Scientific journal
- Mar. 2012, 日本眼科学会雑誌, 116(臨増) (臨増), 265, Japaneseranibizumab硝子体内投与後のAMD再発例における臨床的及び遺伝的関連因子の検討Research society
- 2011, Journal of ophthalmology, Vol. 2011, No. 1, pp. 742020-7, EnglishEarly responses to intravitreal ranibizumab in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy[Refereed]Scientific journal
- 2014, OPHTHALMOLOGICA, 231(2) (2), 59 - 74, EnglishBook review
- May 2012, 日本医事新報, (4593) (4593), 84 - 89, Japanese内科医のための眼科疾患の基礎知識Introduction scientific journal
■ Lectures, oral presentations, etc.
- 第57回日本網膜硝子体学会総会, Dec. 2018, Japanese, 京都, Domestic conference滲出型加齢黄斑変性の固視に関する検討Oral presentation
- 第57回日本網膜硝子体学会総会, Dec. 2018, Japanese, 京都, Domestic conferenceポリープ状脈絡膜血管症へのaflibercept単独療法とaflibercept併用光線力学的療法との2年経過の比較Oral presentation
- 第57回日本網膜硝子体学会総会, Dec. 2018, Japanese, 京都, Domestic conferenceOCT angiographyを用いた糖尿病網膜症発症前後の網膜微小血管及び網膜構造変化の解析Oral presentation
- 第57回日本網膜硝子体学会総会, Dec. 2018, Japanese, 京都, Domestic conferenceEn face slab OCT像を用いた網膜静脈分枝閉塞症の乳頭黄斑線維束障害についての検討Oral presentation
- 第5回神戸大学眼科オープンカンファレンス, Nov. 2018, Japanese, 神戸, Domestic conference下垂体茎断裂症候群に対するホルモン治療中に進行性の網膜変性症の合併を認めた1症例Oral presentation
- 第72回日本臨床眼科学会, Oct. 2018, Japanese, 東京, Domestic conference裂孔原性網膜剥離に対する27ゲージ硝子体手術後の歪視量に寄与する周術期因子の検討Oral presentation
- 第72回日本臨床眼科学会, Oct. 2018, Japanese, 東京, Domestic conference糖尿病眼におけるslab en face OCT像と網膜内層厚Oral presentation
- 第33回日糖尿病合併症学会・第24回日本糖尿病眼学会総会, Oct. 2018, Japanese, 東京, Domestic conference糖尿病黄斑浮腫治療成績とOCT en face slab像の関係Oral presentation
- 第72回日本臨床眼科学会, Oct. 2018, Japanese, 東京, Domestic conferenceポリープ状脈絡膜血管症に対するaflibercept併用光線力学的療法の3年経過Oral presentation
- 第72回日本臨床眼科学会, Oct. 2018, Japanese, 東京, Domestic conferenceVogt-小柳-原田病治療後の脈絡膜構造変化と再発前変動の検討Oral presentation
- 日本臨床視覚電気生理学会, Sep. 2018, Japanese, 浜松, Domestic conference下垂体茎断裂症候群に対するホルモン治療中に進行性の網膜変性症の合併を認めた1例Oral presentation
- 第52回日本眼炎症学会, Jul. 2018, Japanese, 東京, Domestic conference神戸大学眼科における非感染性ぶどう膜炎に対するアダリムマブの使用経験Oral presentation
- フォーサム2018東京, Jul. 2018, English, 東京, Domestic conferenceInternational Distinguished Papers Symposium Characteristics of vitreous cells in uveitis on optical coherence tomographyOral presentation
- フォーサム2018東京, Jul. 2018, Japanese, 東京, Domestic conference3歳女児に生じたVogt-小柳-原田病疑い症例Oral presentation
- WOC, Jun. 2018, English, バルセロナ, International conferenceTime Course of Changes in Aqueous Flare Intensity after 27-gauge pars plana Vitrectomy for Primary Rhegmatogenous Retinal DetachmentOral presentation
- 第122回日本眼科学会総会, Apr. 2018, Japanese, 大阪, Domestic conference裂孔原性網膜剥離に対する27G硝子体手術後の前房フレア値に寄与する周術期因子の検討Oral presentation
- 第122回日本眼科学会総会, Apr. 2018, Japanese, 大阪, Domestic conference光干渉断層計slab en face像を用いた糖尿病網膜内層構造変化の評価Oral presentation
- 第122回日本眼科学会総会, Apr. 2018, Japanese, 大阪, Domestic conferenceポリープ状脈絡膜血管症へのアフリベルセプト併用光線力学療法後の網膜色素上皮萎縮Oral presentation
- 第122回日本眼科学会総会, Apr. 2018, Japanese, 大阪, Domestic conferenceポリープ状脈絡膜血管症に対する光線力学的療法及びaflibercept併用療法と脈絡膜変化Oral presentation
- ARVO, Apr. 2018, English, ホノルル, International conferenceThe association of age-related maculopathy susceptibility 2 gene polymorphisms with the 12 months outcomes of combination therapy with intravitreal aflibercept and verteporfin photodynamic therapy for polypoidal choroidal vasculopathy.Oral presentation
- ARVO, Apr. 2018, English, ホノルル, International conferenceStructural changes in the inner retina assessed by slab en face optical coherence tomography in diabetic eyes.Oral presentation
- ARVO, Apr. 2018, English, ホノルル, International conferenceEvaluation of vitreoretinal cellular infiltration in uveitis on optical coherence tomography.Oral presentation
- APVS2013, Dec. 2013, English, Japanese Retina and Vitreous Society, 名古屋, International conferenceThe Short Term Outcomes of a Single Intravitreal Injection of Aflibercept Combined With Photodynamic Therapy for Polypoidal Choroidal VasculopathyOral presentation
- APVS2013, Dec. 2013, English, Japanese Retina and Vitreous Society, 名古屋, International conferenceThe natural course and response to treatments in the cases with peripapillary polypoidal choroidal vasculopathy,Oral presentation
- APVS2013, Dec. 2013, English, Japanese Retina and Vitreous Society, 名古屋, International conferenceThe early response to aflibercept in the recurrent neovascular age-related macular degeneration after ranibizumab treatment.Oral presentation
- The 67th Annual Congress of Japan Clinical Ophthalmology, Oct. 2013, Japanese, Japanese Ophthalmological Society, 横浜, Domestic conference網膜中心静脈閉塞症合併黄斑浮腫にBevacizumab硝子体内注射後無還流領域を来たした症例Oral presentation
- The 67th Annual Congress of Japan Clinical Ophthalmology, Oct. 2013, Japanese, Japanese Ophthalmological Society, 横浜, Domestic conference黄斑浮腫を伴う網膜中心静脈閉塞症に対するBevacizumab治療の6カ月成績と予後予測因子Oral presentation
- The 67th Annual Congress of Japan Clinical Ophthalmology, Oct. 2013, Japanese, Japanese Ophthalmological Society, 横浜, Domestic conferenceポリープ状脈絡膜血管症に対する光線力学療法の治療効果に関連する因子の検討Oral presentation
- The 67th Annual Congress of Japan Clinical Ophthalmology, Oct. 2013, Japanese, Japanese Ophthalmological Society, 横浜, Domestic conferenceジクアホソルナトリウムとレバミピド併用療法の有効性の検討Oral presentation
- The 67th Annual Congress of Japan Clinical Ophthalmology, Oct. 2013, Japanese, Japanese Ophthalmological Society, 横浜, Domestic conferenceAMDに対するranibizumab硝子体注射の導入期治療の成績に関与する遺伝的因子討Oral presentation
- Foursome 2013, Jul. 2013, Japanese, Japanese Ocular Inflammation Society, 大阪, Domestic conference両眼性網膜血管炎を伴う松果体部胚細胞腫の一例Oral presentation
- Foursome 2013, Jul. 2013, Japanese, Japanese Ocular Inflammation Society, 大阪, Domestic conference片眼のYAG後嚢切開術後に両眼の前房蓄膿を呈した若年性慢性虹彩毛様体炎の1例Oral presentation
- Foursome 2013, Jul. 2013, Japanese, Japanese Ocular Inflammation Society, 大阪, Domestic conferenceベーチェット病に類似した羊歯状血管炎を呈した4例Oral presentation
- Foursome 2013, Jul. 2013, Japanese, Japanese Ocular Inflammation Society, 大阪, Domestic conferenceMPPEに組織プラスミノーゲン活性化因子硝子体注射を施工した1例Oral presentation
- ARVO2012, May 2013, English, The Association For Research in Vision and Ophthalmology, Seattle, USA, International conferenceThe association of elastin gene variants with two angiographic subtypes of polypoidal choroidal vasculopathy.Oral presentation
- The 117th Annual Meeting of Japanese Ophthalmological Society, Apr. 2013, Japanese, Japanese Ophthalmological Society, 東京, Domestic conference日本人の成人発症卵黄状黄斑ジストロフィーにおけるRDS遺伝子多型の検討Oral presentation
- The 117th Annual Meeting of Japanese Ophthalmological Society, Apr. 2013, Japanese, Japanese Ophthalmological Society, 東京, Domestic conferenceポリープ状脈絡膜血管症のインドシアニングリーン蛍光造影所見とエラスチン遺伝子多型Oral presentation
- The 117th Annual Meeting of Japanese Ophthalmological Society, Apr. 2013, Japanese, Japanese Ophthalmological Society, 東京, Domestic conferenceフォルスコリンはMrp4KO マウスにおける網膜血管形成を修飾するOral presentation
- 角膜カンファレンス2013, Feb. 2013, Japanese, 角膜カンファレンス, 和歌山, Domestic conferenceシェーグレン症候群と非シェーグレン症候群ドライアイに対するレバミピド点眼の有効性Oral presentation
- The 51st Japanese Retina and Vitreous Society, Nov. 2012, Japanese, Japanese Retina and Vitreous Society, 甲府, Domestic conference絡膜血管症の血管造影に基づくサブタイプと光線力学療法の治療効果の検討Oral presentation
- The 51st Japanese Retina and Vitreous Society, Nov. 2012, Japanese, Japanese Retina and Vitreous Society, 甲府, Domestic conference中心性網脈絡膜症に対する低照射エネルギーPDTの短期成績Oral presentation
- The 51st Japanese Retina and Vitreous Society, Nov. 2012, Japanese, Japanese Retina and Vitreous Society, 甲府, Domestic conference加齢黄斑変性に対するranibizumab硝子体注射の24ヶ月成績Oral presentation
- The 66th Annual Congress of Japan Clinical Ophthalmology, Oct. 2012, Japanese, Japanese Ophthalmological Society, 京都, Domestic conference両眼にポリープ状脈絡膜血管症を生じた一卵性双生児の症例Oral presentation
- The 66th Annual Congress of Japan Clinical Ophthalmology, Oct. 2012, Japanese, Japanese Ophthalmological Society, 京都, Domestic conference中心性漿液性脈絡網膜症に対する光線力学療法のレーザー照射径と治療効果に関する検討Oral presentation
- The 66th Annual Congress of Japan Clinical Ophthalmology, Oct. 2012, Japanese, Japanese Ophthalmological Society, 京都, Domestic conferenceBUT短縮型ドライアイに対するレバミピド点眼及びジクアホソルナトリウム点眼の有効性Oral presentation
- Foursome 2012, Jul. 2012, Japanese, Japanese Ocular Inflammation Society, 横浜, Domestic conference結核性ぶどう膜炎に組織プラスミノーゲン活性化因子硝子体注射を施行した2例Oral presentation
- Foursome 2012, Jul. 2012, Japanese, Japanese Ocular Inflammation Society, 横浜, Domestic conferenceクリオグロブリン血症に伴う血管炎から網膜静脈分枝閉塞症を発症した1症例Oral presentation
- The 116th Annual Meeting of Japanese Ophthalmological Society, Apr. 2012, Japanese, Japanese Ophthalmological Society, 東京, Domestic conferenceranibizumab硝子体内投与後のAMD再発例における臨床的及び遺伝的関連因子の検討Oral presentation
- 第50回日本網膜硝子体学会総会, Dec. 2011, Japanese, 日本網膜硝子体学会, 東京, Domestic conference在胎38週出生の胎児仮死に対する高濃度酸素管理後に重度の未熟児網膜症を呈した1例Oral presentation
- 第65回日本臨床眼科学会, Oct. 2011, Japanese, 日本大学, 東京, Domestic conference狭義加齢黄斑変性とポリープ状脈絡膜血管症に対するranibizumab 硝子体注射の治療成績Oral presentation
- 第65回日本臨床眼科学会, Oct. 2011, Japanese, 日本大学, 東京, Domestic conference狭義加齢黄斑変性とポリープ状脈絡膜血管症におけるCD36遺伝子多型Oral presentation
- スリーサム2011, Jul. 2011, Japanese, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会, 京都, Domestic conference非肉芽腫性ぶどう膜炎を伴ったSweet症候群の2症例Oral presentation
- 第115回日本眼科学会総会, May 2011, Japanese, 日本眼科学会, 東京, Domestic conference網膜内血管腫状増殖に対する光線力学単独療法とテノン嚢下トリアムシノロン併用の比較Oral presentation
- 第115回日本眼科学会総会, May 2011, Japanese, 日本眼科学会, 東京, Domestic conference日本人加齢黄斑変性に対する遺伝情報を利用した光線力学療法の検討Oral presentation
- 第115回日本眼科学会総会, May 2011, Japanese, 日本眼科学会, 東京, Domestic conference近視性脈絡膜血管新生に対する光線力学療法と抗VEGF療法の治療成績Oral presentation
- 視覚と眼科学研究協会会議, May 2011, English, Association for Research in Vision and Ophthalmology, フォートローダデール, 米国, International conferenceThe Early Responses To Intravitreal Ranibizumab In Typical Neovascular Age-related Macular Degeneration And Polypoidal Choroidal Vasculopathy.Oral presentation
- 第49回日本網膜硝子体学会総会, Nov. 2010, Japanese, 日本網膜硝子体学会, 大阪, Domestic conference脈絡膜新生血管を合併したUnilateral retinal pigment epithelium dysgenesisの1例Oral presentation
- 第49回日本網膜硝子体学会総会, Nov. 2010, Japanese, 日本網膜硝子体学会, 大阪, Domestic conferenceビスフォスフォネート薬内服による加齢黄斑変性予防効果の検討Oral presentation
- 第49回日本網膜硝子体学会総会, Nov. 2010, Japanese, 日本網膜硝子体学会, 大阪, Domestic conferenceMacular hole indexの信頼性の検討Oral presentation
- 第47回日本眼感染症学会, Jul. 2010, Japanese, 日本眼感染症学会, 東京, Domestic conferenceリンパ腫様肉芽腫症にサイトメガウイルス網膜炎を伴った1例Oral presentation