Research activity information

• Three-dimensional terahertz near-field imaging evaluation of cochlea

  Luwei Zheng, Haidong Chen, Takeshi Fujita, Akinobu Kakigi, Nicole Allen, Hironaru Murakami, Masayoshi Tonouchi, Kazunori Serita

  Apr. 2025, Optica

  Scientific journal


• Melatonin mitigates UV-induced tumorigenesis and suppresses hearing function deterioration in Xpa-deficient mice.

  Mariko Tsujimoto, Takeshi Fujita, Tatsuya Furukawa, Yaeno Arima, Ken-Ichi Nibu, Chikako Nishigori

  BACKGROUND: Xeroderma pigmentosum (XP) is caused by impaired DNA repair of UV-induced dipyrimidine-photoproducts. XP cells also show impaired repair/removal of ROS or oxidative DNA lesions caused by UV or 4-nitroquinolline 1-oxide (4NQO). Gene profiling indicated that inflammatory response-related genes are significantly upregulated after UV exposure in XP-A model mice. OBJECTIVE: Since XP cells are in the state of oxidative stress and inflammation, we aimed to search for therapeutic agents from anti-oxidants/anti-inflammatory drugs, that potentially improve XP symptoms. METHODS: Several antioxidants were examined for reducing 4NQO-induced oxidative cytotoxicity or UV-induced oxidative DNA damage in XP-A cells. Among them, we focused on melatonin and evaluated its improving effect for Xpa-deficient MEF on UV-induced cytotoxicity and ROS production, and for Xpa-deficient mice on UV-induced skin tumorigenesis and auditory brainstem responses as one of the neurological symptoms. RESULTS: Melatonin and nicotinamide attenuated 4NQO-induced oxidative cytotoxicity. UV-induced intracellular ROS production and cytotoxicity were improved by melatonin for Xpa-deficient MEF. Finally, the administration of melatonin mitigated UV-induced skin inflammation and tumorigenesis and suppressed hearing deterioration in Xpa-deficient mice. CONCLUSION: Our results show that melatonin could alleviate XP symptoms through its anti-inflammatory and antioxidant properties.

  Jan. 2025, Journal of dermatological science, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Transcanal Endoscopic Ear Surgery for Pediatric Bilateral Congenital Cholesteatoma: A Report of Two Cases.

  Takashi Ueda, Takeshi Fujita, Natsumi Uehara, Jun Yokoi, Mitsuko Yui, Ayu Akazawa, Toshihiko Yamashita, Yukako Goto, Akinobu Kakigi, Ken-Ichi Nibu

  Bilateral congenital cholesteatoma (BCC) is rare among congenital cholesteatoma (CC) cases, and bilateral surgery poses a significant psychophysical burden on pediatric patients. Here, we present 2 pediatric cases of BCC that were successfully managed using simultaneous bilateral transcanal endoscopic ear surgery (TEES). The surgical approach provided clear visualization of the middle ear structures, enabling successful cholesteatoma removal with minimal invasiveness and a short operative time. In both cases, follow-up computed tomography showed no recurrence, and pure-tone audiometry results demonstrated good outcomes. Simultaneous bilateral TEES can be a viable option for pediatric BCC, as it reduces patient burden due to its less invasive procedure and short operative time.

  Nov. 2024, The journal of international advanced otology, 20(6) (6), 540 - 542, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 日耳鼻若手会員・基幹施設への出産・育児に関するアンケート調査結果 働き方改革に関するワーキンググループ報告

  藤田 岳, 森田 由香, 松延 毅, 丸山 裕美子, 櫻井 結華, 吉川 衛, 角南 貴司子, 小林 一女, 丹生 健一, 日本耳鼻咽喉科頭頸部外科学会働き方改革に関するワーキンググループ

  (一社)日本耳鼻咽喉科頭頸部外科学会, Oct. 2024, 日本耳鼻咽喉科頭頸部外科学会会報, 127(10) (10), 1064 - 1071, Japanese


• 日本耳鼻咽喉科頭頸部外科学会 働き方改革に関するWG活動報告 働き方改革に関するアンケート結果

  櫻井 結華, 藤田 岳, 森田 由香, 吉川 衛, 角南 貴司子, 小林 一女, 丹生 健一, 日本耳鼻咽喉科頭頸部外科学会働き方改革に関するワーキンググループ

  (一社)日本耳鼻咽喉科頭頸部外科学会, Sep. 2024, 日本耳鼻咽喉科頭頸部外科学会会報, 127(9) (9), 994 - 1003, Japanese


• Expression of EGFR and p16 in Squamous Cell Carcinoma of External Auditory Canal.

  Yasuyuki Kajimoto, Hirotaka Shinomiya, Natsumi Uehara, Masanori Teshima, Takeshi Fujita, Akinobu Kakigi, Yoshinori Imamura, Naomi Kiyota, Daisuke Miyawaki, Ryohei Sasaki, Hidehito Kimura, Ken-Ichi Nibu

  The expression of EGFR and p16 in the external auditory canal squamous cell carcinoma (EACSCC) and their impacts on oncological outcomes were not well studied. Seventeen-one consecutive patients who were treated for EACSCC at Kobe University Hospital from 1995 to 2018 were enrolled in this study. The expression of EGFR, and p16 were evaluated and their impacts on oncological outcomes were statistically analyzed. Positive expression of EGFR was observed in 62 patients (87%). Strong positive expression of p16 were observed in 18 patients (32.4%), and weakly positive expression in 30 patients (42.3%), respectively. While the number of the patients with negative EGFR expression were limited, all the surgically treated patients with negative EGFR expression have been alive without disease. In the patients with T3 & T4a EACSCC, prognosis of the patients with positive p16 expression EACSCC tended to be better than those with negative p16 expression. These results suggest the clinical significance of EGFR and p16 expressions in the patients with advanced EACSCC to predict oncological outcomes.

  Jan. 2024, The Kobe journal of medical sciences, 69(4) (4), E144-E150, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Identification of immune-related candidate biomarkers in plasma of patients with sporadic vestibular schwannoma.

  Sasa Vasilijic, Nadia A Atai, Hiroshi Hyakusoku, Steven Worthington, Yin Ren, Jessica E Sagers, Mehmet I Sahin, Alyssa Brown, Rohan Reddy, Charvi Malhotra, Takeshi Fujita, Lukas D Landegger, Richard Lewis, D Bradley Welling, Konstantina M Stankovic

  Vestibular schwannoma (VS) is an intracranial tumor arising from neoplastic Schwann cells and typically presenting with hearing loss. The traditional belief that hearing deficit is caused by physical expansion of the VS, compressing the auditory nerve, does not explain the common clinical finding that patients with small tumors can have profound hearing loss, suggesting that tumor-secreted factors could influence hearing ability in VS patients. We conducted profiling of patients' plasma for 66 immune-related factors in patients with sporadic VS (N > 170) and identified and validated candidate biomarkers associated with tumor size (S100B) and hearing (MCP-3). We further identified a nine-biomarker panel (TNR-R2, MIF, CD30, MCP-3, IL-2R, BLC, TWEAK, eotaxin, and S100B) with outstanding discriminatory ability for VS. These findings revealed possible therapeutic targets for VS, providing a unique diagnostic tool that may predict hearing change and tumor growth in VS patients, and may inform the timing of tumor resection to preserve hearing.

  Nov. 2023, Science advances, 9(45) (45), eadf7295, English, International magazine

  Scientific journal


• 放射線誘発前庭障害をきたした外耳道癌症例

  横井 純, 山下 俊彦, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本めまい平衡医学会, Oct. 2023, Equilibrium Research, 82(5) (5), 505 - 505, Japanese


• 高齢者における人工内耳の装用効果

  岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Sep. 2023, Audiology Japan, 66(5) (5), 330 - 330, Japanese


• Oncological outcomes of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil for locally advanced squamous cell carcinoma of the external auditory canal: A single-center study.

  Akihiro Yamada, Hirotaka Shinomiya, Natsumi Uehara, Keisuke Iritani, Shun Tatehara, Tatsuya Furukawa, Masanori Teshima, Daisuke Miyawaki, Takeshi Fujita, Akinobu Kakigi, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu

  BACKGROUND: Squamous cell carcinoma of the external auditory canal (EACSCC) is a rare condition. However, a standard treatment has not yet been established. We retrospectively evaluated the efficacy, adverse events, and feasibility of TPF-CCRT (concomitant chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil) in patients with advanced EACSCC. METHODS: Thirty-five consecutive patients with advanced EACSCC (T3, T4) initially treated with TPF-CCRT at Kobe University Hospital were included. T4 diseases with invasion of the brain, internal carotid artery, or internal jugular vein were classified as T4b, and those without these features were classified as T4a. RESULTS: Five-year overall survival rates for T3 and T4 were 100% and 64.2%, respectively. A significant difference was observed between T4a and T4b (82.4% vs. 30%, p = 0.007). Five-year progression-free survival rates of T3, T4a, and T4b were 100%, 68%, and 20% (p = 0.022), respectively. CONCLUSIONS: TPF-CCRT should be considered as a plausible treatment option for advanced EACSCC.

  Jul. 2023, Head & neck, English, International magazine

  Scientific journal


• Live Imaging of the Dehydration Effect of Isosorbide on the Normal and Hydropic Guinea Pig Cochleae Using Optical Coherence Tomography.

  Akinobu Kakigi, Naoya Egami, Takeshi Fujita, Natsumi Uehara, Jun Yokoi, Kento Koda, Ken-Ichi Nibu, Shinji Yamashita, Tatsuya Yamasoba

  OBJECTIVE: To investigate the isosorbide-induced dehydration effect on the endolymphatic space by intratympanic administration of isosorbide. BACKGROUND: Isosorbide, an osmotic diuretic, is used orally as a typical conservative therapy for Menière's disease (MD) in Japan. The dehydration effect occurs 6 hours after isosorbide ingestion. Intratympanic administration of isosorbide resolves endolymphatic hydrops faster than oral ingestion. In addition, the dehydration effect has never been shown directly. Therefore, we investigated the dehydration effect of intratympanic administration of isosorbide on endolymphatic hydrops using optical coherence tomography. METHODS: We used eight Hartley guinea pigs, divided into normal and hydrops groups. In the hydrops group, the animals underwent endolymphatic sac obliteration to create endolymphatic hydrops. We obtained midmodiolar section images of the cochleae using optical coherence tomography. Then, 50 to 70% isosorbide was sequentially administered intratympanically for 5 minutes, and the apical turn of the cochlea was observed. The relative midmodiolar cross-sectional area of the scala media was calculated for quantitative assessment of the endolymphatic space. RESULTS: In the normal group, 50% isosorbide had a slight but significant dehydration effect on the scala media; at 55 to 70%, Reissner's membrane became flat. In the hydrops group, 50% isosorbide slightly reduced endolymphatic hydrops; 65% flattened Reissner's membrane, and 70% slightly concaved it toward the basilar membrane. CONCLUSION: The results suggest that we could select the concentration of isosorbide according to the stage or severity of MD and relief from acute attack. Intratympanic administration of isosorbide may be a promising treatment for patients with MD.

  Jul. 2023, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, English, International magazine

  Scientific journal


• Clinical trial on the efficacy and safety of NPC-15 for patients with xeroderma pigmentosum exaggerated sunburn reaction type: XP-1 study protocol for a multicentre, double-blinded, placebo-controlled, two-group crossover study followed by a long-term open study in Japan.

  Mariko Tsujimoto, Yasumasa Kakei, Nozomi Yamano, Takeshi Fujita, Takehiro Ueda, Ryusuke Ono, Sae Murakami, Shinichi Moriwaki, Chikako Nishigori

  INTRODUCTION: Xeroderma pigmentosum (XP) is a rare intractable disease without a fundamental treatment, presenting with severe photosensitivity, freckle-like pigmented and depigmented maculae and numerous skin cancers before the age of 10 years without strict sun protection. About 70% of the patients exhibit extremely severe sunburn reactions and most of them develop neurological symptoms, including sensorineural hearing impairment and progressive peripheral and central nervous disorders beginning from childhood ages. In the preclinical study, we found that N-acetyl-5-methoxytryptamine was effective in suppressing skin tumour development in addition to improvement of auditory brainstem response in chronically ultraviolet-irradiated XP-A model mice. METHODS AND ANALYSIS: On the bases of the preclinical study, we conduct a clinical trial on the efficacy of NPC-15 for patients with XP with exaggerated sunburn reaction type by a multicentre, double-blinded placebo-controlled, two-group crossover study followed by a 52 weeks open study. ETHICS AND DISSEMINATION: Ethics approval is overseen by the Kobe University Institutional Review Board and Osaka Medical and Pharmaceutical University Institutional Review Board, and the study is conducted in accordance with the approved protocol. All participants will be required to provide written informed consent. Findings will be disseminated through scientific and professional conferences and peer-reviewed journal publications. The data sets generated during the study will be available from the corresponding author on reasonable request. TRIAL REGISTRATION NUMBER: jRCTs051210181.

  Mar. 2023, BMJ open, 13(3) (3), e068112, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 耳科手術支援ロボットの開発

  藤田 岳, 上原 奈津美, 山下 俊彦, 西川 敦, 河合 俊和, 鈴木 寿, 横井 純, 柿木 章伸, 丹生 健一

  日本耳鼻咽喉科頭頸部外科学会, Mar. 2023, 日本耳鼻咽喉科頭頸部外科学会会報, 126(3) (3), 181 - 184, Japanese, Domestic magazine


• Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas.

  Takeshi Fujita, Kazuko Sakai, Natsumi Uehara, Yujiro Hoshi, Anjin Mori, Hajime Koyama, Mitsuo Sato, Kazuya Saito, Yasuhiro Osaki, Kazuto Nishio, Katsumi Doi

  Vestibular schwannoma (VS) is the most common tumor of the cerebellopontine angle. Despite the increasing diagnosis of sporadic VS over the past decade, the use of traditional microsurgeries to treat VS has decreased. This is likely a result of the adoption of serial imaging as the most common initial evaluation and treatment strategy, especially for small-sized VS. However, the pathobiology of VSs remains unclear, and elucidating the genetic information of tumor tissue may reveal novel insights. The present study performed a comprehensive genomic analysis of all exons in the key tumor suppressor and oncogenes from 10 small (<15 mm) sporadic VS samples. The evaluations identified NF2, SYNE1, IRS2, APC, CIC, SDHC, BRAF, NUMA1, EXT2, HRAS, BCL11B, MAGI1, RNF123, NLRP1, ASXL1, ADAMTS20, TAF1L, XPC, DDB2 and ETS1 as mutated genes. The current study could not draw any new conclusions about the relationship between VS-related hearing loss and gene mutations; however, it did reveal that NF2 was the most frequently mutated gene in small sporadic VS.

  Mar. 2023, Oncology letters, 25(3) (3), 121 - 121, English, International magazine

  Scientific journal


• Identification of Immune-Related Candidate Biomarkers in Plasma of Patients with Sporadic Vestibular Schwannoma.

  Sasa Vasilijic, Nadia A Atai, Hiroshi Hyakusoku, Steven Worthington, Yin Ren, Jessica E Sagers, Mehmet I Sahin, Takeshi Fujita, Lukas D Landegger, Richard Lewis, D Bradley Welling, Konstantina M Stankovic

  UNLABELLED: Vestibular schwannoma (VS) is intracranial tumor arising from neoplastic Schwann cells, causing hearing loss in about 95% of patients. The traditional belief that hearing deficit is caused by physical expansion of the VS, compressing the auditory nerve, does not explain the common clinical finding that patients with small tumors can have profound hearing loss, suggesting that tumor-secreted factors could influence hearing ability in VS patients. Here, we conducted profiling of patients’ plasma for 67 immune-related factors on a large cohort of VS patients (N>120) and identified candidate biomarkers associated with tumor growth (IL-16 and S100B) and hearing (MDC). We identified the 7-biomarker panel composed of MCP-3, BLC, S100B, FGF-2, MMP-14, eotaxin, and TWEAK that showed outstanding discriminatory ability for VS. These findings revealed possible therapeutic targets for VS-induced hearing loss and provided a unique diagnostic tool that may predict hearing change and tumor growth in VS patients and may help inform the ideal timing of tumor resection to preserve hearing. TEASER: Profiling of plasma in vestibular schwannoma patients revealed biomarkers that could predict hearing change and tumor growth.

  Jan. 2023, bioRxiv : the preprint server for biology, English, International magazine


• miR-431 secreted by human vestibular schwannomas increases the mammalian inner ear's vulnerability to noise trauma.

  Takeshi Fujita, Richard Seist, Shyan-Yuan Kao, Vitor Soares, Lorena Panano, Radhika S Khetani, Lukas D Landegger, Shelley Batts, Konstantina M Stankovic

  INTRODUCTION: Vestibular schwannoma (VS) is an intracranial tumor that arises on the vestibular branch of cranial nerve VIII and typically presents with sensorineural hearing loss (SNHL). The mechanisms of this SNHL are postulated to involve alterations in the inner ear's microenvironment mediated by the genetic cargo of VS-secreted extracellular vesicles (EVs). We aimed to identify the EV cargo associated with poor hearing and determine whether its delivery caused hearing loss and cochlear damage in a mouse model in vivo. METHODS: VS tissue was collected from routinely resected tumors of patients with good (VS-GH) or poor (VS-PH) pre-surgical hearing measured via pure-tone average and word recognition scores. Next-generation sequencing was performed on RNA isolated from cultured primary human VS cells and EVs from VS-conditioned media, stratified by patients' hearing ability. microRNA expression levels were compared between VS-PH and VS-GH samples to identify differentially expressed candidates for packaging into a synthetic adeno-associated viral vector (Anc80L65). Viral vectors containing candidate microRNA were infused to the semicircular canals of mice to evaluate the effects on hearing, including after noise exposure. RESULTS: Differentially expressed microRNAs included hsa-miR-431-5p (enriched in VS-PH) and hsa-miR-192-5p (enriched in VS-GH). Newborn mice receiving intracochlear injection of viral vectors over-expressing hsa-miR-431-GFP, hsa-miR-192-GFP, or GFP only (control) had similar hearing 6 weeks post-injection. However, after acoustic trauma, the miR-431 group displayed significantly worse hearing, and greater loss of synaptic ribbons per inner hair cell in the acoustically traumatized cochlear region than the control group. CONCLUSION: Our results suggest that miR-431 contributes to VS-associated hearing loss following cochlear stress. Further investigation is needed to determine whether miR-431 is a potential therapeutic target for SNHL.

  2023, Frontiers in neurology, 14, 1268359 - 1268359, English, International magazine

  Scientific journal


• Vestibular function after simultaneous bilateral cochlear implantation in adults.

  Jun Yokoi, Takeshi Fujita, Natsumi Uehara, Shinobu Iwaki, Akinobu Kakigi, Ken-Ichi Nibu

  INTRODUCTION: Binaural hearing enhances speech intelligibility, source localization, and speech comprehension in noisy environments. Although bilateral cochlear implantation (CI) offers several benefits, concerns arise regarding the risk of bilateral postoperative vestibular dysfunction with simultaneous CI. This study aimed to longitudinally evaluate changes in vestibular function in adult patients who underwent simultaneous bilateral CI using minimally invasive electrodes and surgical techniques. METHODS: A retrospective review was conducted on 10 patients who underwent simultaneous bilateral CI at our hospital. Vertigo symptoms and vestibular function test results were examined preoperatively, 1-6 months postoperatively, and 1 year postoperatively. Nystagmus tests, caloric reflex tests, vestibular evoked myogenic potentials (VEMP) measurements, and static stabilometry were performed as vestibular function tests. RESULTS: Although an initial transient decline in vestibular function was observed, no significant long-term decline was observed in the caloric reflex test, ocular VEMP (oVEMP), or cervical VEMP (cVEMP). Moreover, regardless of the presence or absence of abnormalities in caloric reflex, oVEMP, or cVEMP, no significant deterioration was detected in the static stabilometer test. While two patients reported preoperative dizziness, all patients were symptom-free 1 year postoperatively. DISCUSSION: The findings suggest that using current minimally invasive electrodes and surgical techniques in simultaneous bilateral CI leads to temporary vestibular function decline postoperatively. However, most patients experience a recovery in function over time, highlighting the potential safety and efficacy of the procedure. Simultaneous bilateral CI surgery is viable, depending on the patient's auditory needs and burden.

  2023, Frontiers in neurology, 14, 1304927 - 1304927, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Hearing loss in mice with disruption of auditory epithelial patterning in the cochlea

  Sayaka Katsunuma, Hideru Togashi, Shuhei Kuno, Takeshi Fujita, Ken-Ichi Nibu

  In the cochlear auditory epithelia, sensory hair and supporting cells are arranged in a checkerboard-like mosaic pattern, which is conserved across a wide range of species. The cell adhesion molecules nectin-1 and nectin-3 are required for this pattern formation. The checkerboard-like pattern is thought to be necessary for auditory function, but has never been examined. Here, we showed the significance of checkerboard-like cellular pattern in the survival and function of sensory hair cells in the cochlear auditory epithelia of nectin-3 knockout (KO) mice. Nectin-3 KO mice showed progressive hearing loss associated with degeneration of aberrantly attached hair cells via apoptosis. Apoptotic hair cell death was due to the disorganization of tight junctions between the hair cells. Our study revealed that the checkerboard-like cellular pattern in the auditory epithelium provides a structural basis for ensuring the survival of cochlear hair cells and hearing function.

  Frontiers Media SA, Dec. 2022, Frontiers in Cell and Developmental Biology, 10

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Editorial: Otologic Trauma, Pathology, and Therapy.

  Lukas D Landegger, Takeshi Fujita, Taha A Jan, Isabel Varela-Nieto

  2022, Frontiers in cellular neuroscience, 16, 900074 - 900074, English, International magazine


• Facial nerve palsy as the presenting feature of metastatic prostatic cancer in the temporal bone

  Daichi Fujii, Hikari Shimoda, Natsumi Uehara, Takeshi Fujita, Masanori Teshima, Hirotaka Shinomiya, Akinobu Kakigi, Tomoaki Terakawa, Masato Fujisawa, Ken-ichi Nibu

  Informa {UK} Limited, Dec. 2021, Acta Oto-Laryngologica Case Reports, 6(1) (1), 1 - 5

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Examination of risk factors for postoperative vestibular symptoms in patients with cholesteatoma.

  Takaaki Kobayashi, Shusuke Iwamoto, Toshihito Sahara, Yujiro Hoshi, Anjin Mori, Hajime Koyama, Takeshi Fujita, Mitsuo P Sato, Yasuhiro Osaki, Katsumi Doi

  BACKGROUND: In cholesteatoma, the prognosis of tympanoplasty has been well discussed in terms of hearing outcomes and residual or recurrent lesions. Postoperative dizziness and vertigo are major complications of tympanoplasty; however, few reports are available. AIMS/OBJECTIVES: We investigated each condition of cholesteatoma postoperative vestibular risk using the STAM system and staging published by EAONO/JOS, as well as findings on bony destruction. MATERIAL AND METHODS: From April 2010 to March 2021, 156 patients (166 ears) with cholesteatoma who underwent primary microscopic tympanoplasty at our hospital were registered. Subjective vestibular symptoms were recorded the day after surgery. RESULTS: Postoperative vestibular symptoms were observed in 13.9% of subjects. All of them were stage II and had both attic and mastoid lesions. Attic (p < .05) and mastoid (p < .01) lesions were risk factors. Multivariate analysis showed that significant differences were found in past histories of vestibular symptoms (p < .05) and exposure of the dura mater (p < .01). CONCLUSIONS AND SIGNIFICANCE: In the exposed dura group, the length of the prominence of the lateral semicircular canal to the middle cranial fossa dura was significantly shorter than that of the non-exposed group (p < .01). Narrow working space and downward operation may increase vestibular risk.

  Dec. 2021, Acta oto-laryngologica, 142(1) (1), 1 - 6, English, International magazine

  Scientific journal


• Genetic background in late-onset sensorineural hearing loss patients.

  Natsumi Uehara, Takeshi Fujita, Daisuke Yamashita, Jun Yokoi, Sayaka Katsunuma, Akinobu Kakigi, Shin-Ya Nishio, Ken-Ichi Nibu, Shin-Ichi Usami

  Genetic testing for congenital or early-onset hearing loss patients has become a common diagnostic option in many countries. On the other hand, there are few late-onset hearing loss patients receiving genetic testing, as late-onset hearing loss is believed to be a complex disorder and the diagnostic rate for genetic testing in late-onset patients is lower than that for the congenital cases. To date, the etiology of late-onset hearing loss is largely unknown. In the present study, we recruited 48 unrelated Japanese patients with late-onset bilateral sensorineural hearing loss, and performed genetic analysis of 63 known deafness gene using massively parallel DNA sequencing. As a result, we identified 25 possibly causative variants in 29 patients (60.4%). The present results clearly indicated that various genes are involved in late-onset hearing loss and a significant portion of cases of late-onset hearing loss is due to genetic causes. In addition, we identified two interesting cases for whom we could expand the phenotypic description. One case with a novel MYO7A variant showed a milder phenotype with progressive hearing loss and late-onset retinitis pigmentosa. The other case presented with Stickler syndrome with a mild phenotype caused by a homozygous frameshift COL9A3 variant. In conclusion, comprehensive genetic testing for late-onset hearing loss patients is necessary to obtain accurate diagnosis and to provide more appropriate treatment for these patients.

  Nov. 2021, Journal of human genetics, 67(4) (4), 223 - 230, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Machine Learning Technique Reveals Prognostic Factors of Vibrant Soundbridge for Conductive or Mixed Hearing Loss Patients.

  Hajime Koyama, Anjin Mori, Daisuke Nagatomi, Takeshi Fujita, Kazuya Saito, Yasuhiro Osaki, Tatsuya Yamasoba, Katsumi Doi

  OBJECTIVES: Vibrant Soundbridge (VSB) was developed for treatment of hearing loss, but clinical outcomes vary and prognostic factors predicting the success of the treatment remain unknown. We examined clinical outcomes of VSB for conductive or mixed hearing loss, prognostic factors by analyzing prediction models, and cut-off values to predict the outcomes. STUDY DESIGN: Retrospective chart review. SETTING: Tertiary care hospital. PATIENTS: Thirty patients who underwent VSB surgery from January 2017 to December 2019 at our hospital. INTERVENTION: Audiological tests were performed prior to and 3 months after surgery; patients completed questionnaires 3 months after surgery. MAIN OUTCOME MEASURES: We used a multiregression and the random forest algorithm for predictions. Mean absolute errors and coefficient of determinations were calculated to estimate prediction accuracies. Coefficient values in the multiregression model and the importance of features in the random forest model were calculated to clarify prognostic factors. Receiver operation characteristic curves were plotted. RESULTS: All audiological outcomes improved after surgery. The random forest model (mean absolute error: 0.06) recorded more accuracy than the multiregression model (mean absolute error: 0.12). Speech discrimination score in a silent context in patients with hearing aids was the most influential factor (coefficient value: 0.51, featured value: 0.71). The candidate cut-off value was 36% (sensitivity: 89%, specificity: 75%). CONCLUSIONS: VSB is an effective treatment for conductive or mixed hearing loss. Machine learning demonstrated more precise predictions, and speech discrimination scores in a silent context in patients with hearing aids were the most important factor in predicting clinical outcomes.

  Oct. 2021, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 42(9) (9), e1286-e1292, English, International magazine

  Scientific journal


• Phase I trial of concurrent chemoradiotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF-CRT) for locally advanced squamous cell carcinoma of the external auditory canal.

  Hirotaka Shinomiya, Natsumi Uehara, Takeshi Fujita, Daisuke Miyawaki, Yoshinori Imamura, Masanori Teshima, Akinobu Kakigi, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu

  PURPOSE: Chemoradiotherapy with docetaxel (DOC), cisplatin (CDDP), and 5-FU (TPF-CRT) for locally advanced external auditory canal cancer (EACC) has favorable oncological and functional outcomes. To establish TPF-CRT as a standard of care for advanced EACC, we conducted this study to determine the maximum tolerated (MTD) and recommended dose (RD) of DOC in TPF-CRT for locally advanced EACC. METHODS: To determine the recommended (RD) and maximum tolerated dose (MTD) of DOC in TPF-CRT for EACC, a phase I trial was conducted using the standard "3 + 3" design for maximum dose finding. DOC was administered twice every 4 weeks, CDDP at 70 mg/m2 and 5-FU at 700 mg/m2; patients were also receiving radiotherapy (66 Gy). Eight patients with T3 or T4 EACC were prospectively enrolled. RESULTS: Two patients treated with DOC, 50 mg/m2, and one out of six patients treated with DOC, 40 mg/m2, had dose-limiting toxicities. Prolonged febrile neutropenia was observed in three patients. Grade 3 non-hematological toxicities were observed in only three patients. At study completion, six patients survived, five of whom were disease free. CONCLUSION: The RD and MTD of DOC in TPF-CRT for locally advanced EACC are 40 mg/m2 when doses of CDDP and 5-FU are 70 mg/m2 and 700 mg/m2, respectively.

  Jul. 2021, European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 279(6) (6), 2805 - 2810, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• New proposal to revise the classification for squamous cell carcinoma of the external auditory canal and middle ear

  H Shinomiya, N Uehara, T Fujita, K Yoshida, Y Imamura, M Teshima, H Kimura, D Miyawaki, A Kakigi, N Kiyota, N Otsuki, R Sasaki, E Kohmura, K Nibu

  The prognosis of patients with advanced squamous cell carcinoma of the external auditory canal and middle ear has been improved by advances in skull base surgery and multidrug chemoradiotherapy during the last two decades. Ninety-five patients with squamous cell carcinoma of the external auditory canal and middle ear who were treated between 1998 and 2017 were enrolled. The number of patients with tumour stages T₁, T₂, T₃ and T₄ was 15, 22, 24 and 34, respectively. Oncological outcomes and prognostic factors were retrospectively investigated. Among patients with T₄ disease, invasion of the brain (p = 0.024), carotid artery (p = 0.049) and/or jugular vein (p = 0.040) were significant predictors of poor prognosis. The five-year overall survival rate of patients with at least one of these factors (T_4b) was significantly lower than that of patients without these factors (T_4a) (25.5 vs 65.5 per cent, p = 0.049). It is proposed that stage T₄ be subclassified into T_4a and T_4b according to the prognostic factors.

  Cambridge University Press (CUP), Apr. 2021, The Journal of Laryngology & Otology, 135(4) (4), 297 - 303

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 当科における顔面神経鞘腫23例の検討

  下田 光, 柿木 章伸, 横井 純, 上原 奈津美, 藤田 岳, 丹生 健一, 橋川 和信, 甲村 英二

  日本顔面神経学会, Mar. 2021, Facial Nerve Research, 40, 197 - 201, Japanese


• Vestibular function in minimally invasive cochlear implantation

  Jun Yokoi, Shun-Gaku Yanagisawa, Akinobu Kakigi, Takeshi Fujita, Shinobu Iwaki, Yasuyuki Kajimoto, Ken-Ichi Nibu

  Japan Society for Equilibrium Research, Feb. 2021, Equilibrium Research, 80(1) (1), 31 - 40, Japanese

  Scientific journal


• Reconstruction of the external auditory canal using full-thickness rolled-up skin graft after lateral temporal bone resection for T1 and T2 external auditory canal cancer.

  Takeshi Fujita, Akinobu Kakigi, Natsumi Uehara, Jun Yokoi, Makiko Hara, Hirotaka Shinomiya, Masanori Teshima, Ken-Ichi Nibu

  OBJECTIVE: To present our results of the external auditory canal (EAC) reconstruction procedure using rolled-up full-thickness skin graft with tympanoplasty after lateral temporal bone resection (LTBR) for early-stage EAC carcinoma. PATIENTS AND METHODS: A retrospective review of 15 patients who had undergone LTBR with reconstruction of the EAC for T1 and T2 EAC cancer between 2016 and 2020. RESULTS: Postoperative mean air-bone gap was 30.7 decibel hearing level. Although a few patients experienced chronic granulation, persistent otorrhea, and/or laterization of the tympanic membrane, most patients showed no serious complications related to the EAC reconstruction. CONCLUSION: EAC reconstruction using a full-thickness skin graft in combination with tympanoplasty is useful for minimizing the hearing loss, maintaining the cosmetic appearance, and facilitating the observation into the ear cavity.

  Jan. 2021, Auris, nasus, larynx, English, International magazine

  Scientific journal


• 両側同時人工内耳手術を施行した成人例における聴取成績

  岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Sep. 2020, Audiology Japan, 63(5) (5), 333 - 333, Japanese


• Tonsillectomy as an effective treatment for arthralgia of SAPHO syndrome

  Sena Horiguchi, Takeshi Fujita, Koji Kinoshita, Katsumi Doi

  Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome has been proposed to describe a clinicoradiological entity manifesting in the joints, skin and bones. We describe a patient with SAPHO syndrome for whom bilateral tonsillectomy was effective for the treatment of arthralgia, which was quantified using multiple pain scales.

  Oxford University Press ({OUP}), Sep. 2020, Journal of Surgical Case Reports, 2020(9) (9), rjaa288, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Live imaging and functional changes of the inner ear in an animal model of Meniere's disease.

  Akinobu Kakigi, Naoya Egami, Natsumi Uehara, Takeshi Fujita, Ken-Ichi Nibu, Shinji Yamashita, Tatsuya Yamasoba

  The symptoms of Meniere's disease (MD) are generally considered to be related to endolymphatic hydrops (EH). There are many recent reports supporting the possibility that vasopressin (VP) is closely linked to the formation of EH in Meniere's disease. Based on this, we developed a clinically relevant animal model of Meniere's disease in which a VP type 2 receptor agonist was administered after electrocauterization of the endolymphatic sac. We report live imaging of the internal structure, and functional changes of the inner ear after electrocauterization of the endolymphatic sac and administration of a VP type 2 receptor agonist. In this model, the development of EH was visualized in vivo using optical coherence tomography, there was no rupture of Reissner's membrane, and low-tone hearing loss and vertiginous attacks were observed. This study suggested that acute attacks are caused by the abrupt development of EH. This is the first report of live imaging of the development of EH induced by the administration of a VP type 2 receptor agonist.

  Jul. 2020, Scientific reports, 10(1) (1), 12271 - 12271, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Traumatic perilymphatic fistula caused by a camellia branch: A case report

  Natsumi Uehara, Takeshi Fujita, Ken-ichi Nibu, Akinobu Kakigi

  Jan. 2020, Acta Oto-Laryngologica Case Reports, 5(1) (1), 101 - 105, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Prevalence of potential candidates for electric-acoustic stimulation implant in a hearing-impaired population.

  Saito K, Fujita T, Osaki Y, Koyama H, Shiraishi K, Kobayashi T, Sato M, Seo T, Doi K

  OBJECTIVE: To estimate the prevalence of potential electric-acoustic stimulation (EAS) implant candidates in a hearing-impaired population through a review of auditory examinations. METHODS: In total, 7356 patients underwent audiometric examination in our department between 2011 and 2014. The prevalence of patients meeting the audiometric criteria for EAS and standard cochlear implant (CI) was assessed. RESULTS: The percentage of EAS implant candidates meeting the pure-tone audiometric criteria was 0.71% (n=34) among the hearing-impaired individuals (n=4758) examined in our department, whereas 2.52% (n=120) met the criteria for standard CI. Among the 34 EAS implant candidates, 2 individuals (5.83%) received EAS implant surgery after approval of the EAS device in Japan. CONCLUSIONS: There was a lower prevalence of EAS implant candidates than standard CI candidates. Nevertheless, healthcare professionals should carefully examine the audiograms of patients with high frequency hearing loss with regard to meeting the indication criteria for EAS implant. This will enable patients to gain access to adequate information relating to further examinations and treatment options.

  Aug. 2019, Auris, nasus, larynx, 47(2) (2), 198 - 202, English, International magazine

  [Refereed]

  Scientific journal


• Primary Liposarcoma with Cholesteatoma in Mastoid.

  Sato MP, Saito K, Fujita T, Seo T, Doi K

  Jul. 2019, The journal of international advanced otology

  [Refereed]


• The prevalence of vestibular schwannoma among patients treated as sudden sensorineural hearing loss

  Takeshi Fujita, Kazuya Saito, Nobuo Kashiwagi, Mitsuo Sato, Toru Seo, Katsumi Doi

  Elsevier {BV}, Feb. 2019, Auris Nasus Larynx, 46(1) (1), 78 - 82

  [Refereed]

  Scientific journal


• Vestibule-Middle Ear Dehiscence Tested With Perilymph-Specific Protein Cochlin-Tomoprotein (CTP) Detection Test.

  Fujita T, Kobayashi T, Saito K, Seo T, Ikezono T, Doi K

  An 8-year-old boy was referred to the ENT department for further evaluation of right-sided conductive hearing loss. A small cyst anterior to the oval window and fixation of the stapes footplate were observed during an exploratory tympanotomy. The concentration of a perilymph-specific protein, cochlin-tomoprotein (CTP), in the middle ear lavage fluid was measured with an ELISA-based CTP detection kit. The level of CTP in the middle ear lavage fluid before fenestration of the cyst was 0.26 ng/ml (negative), and its level after fenestration was 2.98 ng/ml (positive), confirming the presence of perilymph in the cyst. A small bone dehiscence, considered to be the fissula ante fenestram, was observed anterior to the stapes footplate after removal of the cyst. The CTP detection test results allowed us to confirm that the small bone dehiscence was connected to the inner ear.

  2019, Frontiers in neurology, 10, 47 - 47, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma.

  Chen J, Landegger LD, Sun Y, Ren J, Maimon N, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Roberge S, Huang P, Jain RK, Plotkin SR, Stankovic KM, Xu L

  Jan. 2019, Nature protocols

  [Refereed]


• Cytokine Levels in Inner Ear Fluid of Young and Aged Mice as Molecular Biomarkers of Noise-Induced Hearing Loss.

  Lukas D Landegger, Sasa Vasilijic, Takeshi Fujita, Vitor Y Soares, Richard Seist, Lei Xu, Konstantina M Stankovic

  Sensorineural hearing loss (SNHL) is the most common sensory deficit worldwide, frequently caused by noise trauma and aging, with inflammation being implicated in both pathologies. Here, we provide the first direct measurements of proinflammatory cytokines in inner ear fluid, perilymph, of adolescent and 2-year-old mice. The perilymph of adolescent mice exposed to the noise intensity resulting in permanent auditory threshold elevations had significantly increased levels of IL-6, TNF-α, and CXCL1 6 h after exposure, with CXCL1 levels being most elevated (19.3 ± 6.2 fold). We next provide the first immunohistochemical localization of CXCL1 in specific cochlear supporting cells, and its presumed receptor, Duffy antigen receptor for chemokines (DARC), in hair cells and spiral ganglion neurons. Our results demonstrate the feasibility of molecular diagnostics of SNHL using only 0.5 μL of perilymph, and motivate future sub-μL based diagnostics of human SNHL based on liquid biopsy of the inner ear to guide therapy, promote hearing protection, and monitor response to treatment.

  2019, Frontiers in neurology, 10, 977 - 977, English, International magazine

  [Refereed]

  Scientific journal


• Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models.

  Zhao Y, Liu P, Zhang N, Chen J, Landegger LD, Wu L, Zhao F, Zhao Y, Zhang Y, Zhang J, Fujita T, Stemmer-Rachamimov A, Ferraro GB, Liu H, Muzikansky A, Plotkin SR, Stankovic KM, Jain RK, Xu L

  Feb. 2018, Proceedings of the National Academy of Sciences of the United States of America, 115(9) (9), E2077 - E2084

  [Refereed]


• Recent and Frequent Vertigo Attacks Produce Negative Findings on Furosemide-Loading Vestibular Evoked Myogenic Potential Testing in Meniere's Disease.

  Seo T, Shiraishi K, Kobayashi T, Fujita T, Saito K, Doi K

  Objective: The peak-to-peak amplitude of the p13-n23 wave in cervical vestibular evoked myogenic potential can increase after furosemide administration in patients with Meniere's disease [furosemide-loading VEMP (FVEMP) testing]. The examination is used to test for the presence of endolymphatic hydrops; we investigated factors that may influence the results. Methods: Forty-two subjects (23 males and 19 females, aged 24-70 years) with unilateral definite Meniere's disease who underwent FVEMP testing were retrospectively studied. Possible factors associated with the results of FVEMP testing were studied using logistic regression analysis. Results: Ages, sex, affected side, stage, disease duration, and mean hearing level of pure tone audiometry did not influence the results of FVEMP testing in the univariate analysis (p > 0.05). Number of days since the last vertigo attack [odds ratio (OR): 1.07, p = 0.031] and frequency of vertigo attacks per month (OR: 0.42, p = 0.003) were significantly associated with the results of testing. Multivariate analysis showed that both days since the last vertigo attack < 7 (OR: 0.13, p = 0.04) and frequency of vertigo attacks per month ≥ 2 (OR: 0.06, p = 0.004) were risk factors for negative results on FVEMP testing. Conclusion: This study found that recent and frequent vertigo attacks produced negative findings on FVEMP testing in Meniere's disease. This apparently irrational finding can be explained by the consequences of membranous labyrinth rupture during vertigo attacks, where the altered saccular resonance due to EH cannot be recovered by furosemide administration because of the dissolving dehydration effect that occurs through communication between the endolymphatic and perilymphatic spaces. In addition, the impairment of sensory cells that is caused by endolymph and perilymph mixing upon rupture does not improve upon furosemide administration. FVEMP testing results may provide us with pathophysiological information regarding the membranous labyrinth.

  2018, Frontiers in neurology, 9, 636 - 636, English, International magazine

  [Refereed]

  Scientific journal


• A Unified Methodological Framework for Vestibular Schwannoma Research

  Lukas D. Landegger, Jessica E. Sagers, Sonam Dilwali, Takeshi Fujita, Mehmet I. Sahin, Konstantina M. Stankovic

  Jun. 2017, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (124) (124), English

  [Refereed]

  Scientific journal


• Hearing Dysfunction in Xpa-Deficient Mice

  Hitomi Shinomiya, Daisuke Yamashita, Takeshi Fujita, Eiji Nakano, Go Inokuchi, Shingo Hasegawa, Naoki Otsuki, Chikako Nishigori, Ken-ichi Nibu

  Feb. 2017, FRONTIERS IN AGING NEUROSCIENCE, 9, 19, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Residual dizziness after successful treatment of idiopathic benign paroxysmal positional vertigo originates from persistent utricular dysfunction

  Toru Seo, Ko Shiraishi, Takaaki Kobayashi, Kitano Mutsukazu, Takeshi Fujita, Kazuya Saito, Hiroyasu Watanabe, Katsumi Doi

  2017, ACTA OTO-LARYNGOLOGICA, 137(11) (11), 1149 - 1152, English

  [Refereed]

  Scientific journal


• Revision of a furosemide-loading vestibular-evoked myogenic potential protocol for detecting endolymphatic hydrops

  Toru Seo, Ko Shiraishi, Takaaki Kobayashi, Kitano Mutsukazu, Takeshi Fujita, Kazuya Saito, Katsumi Doi

  2017, ACTA OTO-LARYNGOLOGICA, 137(12) (12), 1244 - 1248, English

  [Refereed]

  Scientific journal


• Extracellular vesicles derived from human vestibular schwannomas associated with poor hearing damage cochlear cells

  Vitor Y. R. Soares, Nadia A. Atai, Takeshi Fujita, Sonam Dilwali, Sarada Sivaraman, Lukas D. Landegger, Fred H. Hochberg, Carlos A. P. C. Oliveira, Fayez Bahmad, Xandra O. Breakefield, Konstantina M. Stankovic

  Nov. 2016, NEURO-ONCOLOGY, 18(11) (11), 1498 - 1507, English

  [Refereed]

  Scientific journal


• Sulforaphane, a natural component of broccoli, inhibits vestibular schwannoma growth in vitro and in vivo

  Bo Gyung Kim, Takeshi Fujita, Konstantina M. Stankovic, D. Bradley Welling, In Seok Moon, Jae Young Choi, Jieun Yun, Jong Soon Kang, Jong Dae Lee

  Nov. 2016, SCIENTIFIC REPORTS, 6, 36215, English

  [Refereed]

  Scientific journal


• Surgical Anatomy of the Human Round Window Region: Implication for Cochlear Endoscopy Through the External Auditory Canal

  Takeshi Fujita, Jung Eun Shin, MaryBeth Cunnane, Kyoko Fujita, Simon Henein, Demetri Psaltis, Konstantina M. Stankovic

  Sep. 2016, OTOLOGY & NEUROTOLOGY, 37(8) (8), 1189 - 1194, English

  [Refereed]

  Scientific journal


• Metabolomic profiling in inner ear fluid by gas chromatography/mass spectrometry in guinea pig cochlea

  Takeshi Fujita, Daisuke Yamashita, Yasuhiro Irino, Junko Kitamoto, Yuriko Fukuda, Go Inokuchi, Shingo Hasegawa, Naoki Otsuki, Masaru Yoshida, Ken-ichi Nibu

  Oct. 2015, NEUROSCIENCE LETTERS, 606, 188 - 193, English

  [Refereed]

  Scientific journal


• Preclinical validation of anti-nuclear factor-kappa B therapy to inhibit human vestibular schwannoma growth

  Sonam Dilwali, Martijn C. Briet, Shyan-Yuan Kao, Takeshi Fujita, Lukas D. Landegger, Michael P. Platt, Konstantina M. Stankovic

  Aug. 2015, MOLECULAR ONCOLOGY, 9(7) (7), 1359 - 1370, English

  [Refereed]

  Scientific journal


• Nonsteroidal anti-inflammatory medications are cytostatic against human vestibular schwannomas

  Sonam Dilwali, Shyan-Yuan Kao, Takeshi Fujita, Lukas D. Landegger, Konstantina M. Stankovic

  Jul. 2015, TRANSLATIONAL RESEARCH, 166(1) (1), 1 - 11, English

  [Refereed]

  Scientific journal


• A High-Fat Diet Delays Age-Related Hearing Loss Progression in C57BL/6J Mice

  Takeshi Fujita, Daisuke Yamashita, Natsumi Uehara, Go Inokuchi, Shingo Hasegawa, Naoki Otsuki, Ken-ichi Nibu

  Jan. 2015, PLOS ONE, 10(1) (1), e0117547, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Persistent petrosquamosal sinus: Underlying cause of otitic hydrocephalus with lateral sinus thrombosis

  Go Inokuchi, Nao Tsutsumi, Hirokazu Komatsu, Takeshi Fujita, Naoki Sawada, Kazuo Kumoi

  Nov. 2013, INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 77(11) (11), 1908 - 1911, English

  [Refereed]

  Scientific journal


• Serum and Tissue Metabolomics of Head and Neck Cancer

  Koichiro Yonezawa, Shin Nishiumii, Junko Kitamoto-Matsuda, Takeshi Fujita, Koichi Morimoto, Daisuke Yamashita, Miki Saito, Naoki Otsuki, Yasuhiro Irino, Masakazu Shinohara, Masaru Yoshida, Ken-Ichi Nibu

  Sep. 2013, CANCER GENOMICS & PROTEOMICS, 10(5) (5), 233 - 238, English

  [Refereed]

  Scientific journal


• Increased Inner Ear Susceptibility to Noise Injury in Mice With Streptozotocin-Induced Diabetes

  Takeshi Fujita, Daisuke Yamashita, Sayaka Katsunuma, Shingo Hasegawa, Hitoshi Tanimoto, Ken-ichi Nibu

  Nov. 2012, DIABETES, 61(11) (11), 2980 - 2986, English

  [Refereed]

  Scientific journal

• 外耳癌 診断から治療・術後管理まで 耳科手術専門医が知っておきたい技術 外耳道癌に対する外側側頭骨切除術の適応と実際

  藤田 岳, 柿木 章伸

  (一社)日本耳科学会, Dec. 2024, Otology Japan, 34(4) (4), 183 - 186, Japanese


• 吸水性合成樹脂製玩具(水で膨らむボール)により鼓膜穿孔,耳小骨破壊をきたした1例

  繁治 純, 藤田 岳, 井之口 豪, 安井 理絵

  日本小児耳鼻咽喉科学会, Dec. 2024, 小児耳鼻咽喉科, 45(2) (2), 155 - 158, Japanese


• 【TEES】TEESで治す ロボット手術との関わり

  藤田 岳

  (株)東京医学社, Dec. 2024, JOHNS, 40(12) (12), 1535 - 1537, Japanese


• 【耳鼻咽喉科頭頸部外科領域のサブスペシャルティ-手術指導医・専門医・相談医マニュアル-】耳科手術指導の実際 知っておくべき耳科手術の施設基準,実施医制度,執刀医要件

  藤田 岳

  (株)東京医学社, Oct. 2024, JOHNS, 40(10) (10), 1247 - 1251, Japanese


• 聴神経腫瘍における難聴メカニズムと分子基盤の解明

  藤田 岳

  (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 9 - 9, Japanese


• 小さな宇宙を探究する～耳科学イメージングの世界～ 医工融合で蝸牛内部の可視化を目指す

  藤田 岳

  (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 14 - 14, Japanese


• 聴力改善手術が患者QOLに及ぼす影響 局訳版QOL質問票を用いた検討(第3報)

  細谷 誠, 我那覇 章, 吉村 豪兼, 森田 由香, 高橋 邦行, 山岸 達矢, 松本 希, 藤田 岳, 美内 慎也, 赤井 亮, 白井 杏湖, 樫尾 明憲, 土井 勝美, 大平 乃理子, 伊藤 吏, 後藤 崇成, 高橋 昌寛, 高橋 真理子, 高橋 優宏, 小森 学, 山内 大輔, 本蔵 陽平, 平海 晴一, 綾仁 悠介, 岡田 昌浩, 山本 典生, 池園 哲郎, 松田 帆, 宇佐美 真一, 萩森 伸一, 中川 尚志, 大石 直樹, 東野 哲也, 神崎 晶

  (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 113 - 113, Japanese


• 当院におけるアッシャー症候群の検討

  上原 奈津美, 横井 純, 藤田 岳, 西尾 信哉, 柿木 章伸, 松永 達雄, 宇佐美 真一, 丹生 健一

  (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 185 - 185, Japanese


• 神経線維種症II型(NF2)に対して人工内耳植込術を施行した2症例

  赤座 暁子, 藤田 岳, 上原 奈津美, 横井 純, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 220 - 220, Japanese


• OTOPLANを用いたFLEXsoft人工内耳電極の周波数ミスマッチに関する検討

  横井 純, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 242 - 242, Japanese


• グロムス腫瘍との鑑別に苦慮した側頭骨内顔面神経鞘腫の1例

  渡辺 啓太, 藤田 岳, 横井 純, 柿木 章伸, 上原 奈津美, 丹生 健一

  (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 272 - 272, Japanese


• 長期抗菌薬投与を継続しながら外来治療に移行した頭蓋底骨髄炎の一例

  水本 真理愛, 上原 奈津美, 小池 雪絵, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 295 - 295, Japanese


• 術前に内耳造影MRIにて内リンパ水腫を認めた耳硬化症例

  横井 純, 藤田 岳, 山下 俊彦, 柿木 章伸, 丹生 健一

  (一社)日本めまい平衡医学会, Oct. 2024, Equilibrium Research, 83(5) (5), 396 - 396, Japanese


• 高度難聴と幻聴を伴う統合失調症症例に対する人工内耳装用効果について

  岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Sep. 2024, Audiology Japan, 67(5) (5), 448 - 448, Japanese


• 【耳科診療の論点-異なる立場の対話とディベート-】さまざまな手術法の中から 耳科手術の3鏡について 顕微鏡のメリット,デメリット

  藤田 岳

  (株)東京医学社, Mar. 2024, JOHNS, 40(3) (3), 308 - 310, Japanese


• 耳痛を伴わず診断に難渋した中耳放線菌症の1例

  上原 奈津美, 神澤 真紀, 横井 純, 由井 光子, 井之口 豪, 藤田 岳, 柿木 章伸, 丹生 健一

  日本耳鼻咽喉科免疫アレルギー感染症学会, Mar. 2024, 日本耳鼻咽喉科免疫アレルギー感染症学会誌, 4(1) (1), 31 - 36, Japanese


• 好酸球性副鼻腔炎に対するバイオ製剤治療による中耳炎への効果の検討

  上原 奈津美, 由井 光子, 藤田 岳, 井之口 豪, 柿木 章伸, 丹生 健一

  日本耳鼻咽喉科免疫アレルギー感染症学会, Mar. 2024, 日本耳鼻咽喉科免疫アレルギー感染症学会抄録集, 4回, 216 - 216, Japanese


• 中耳真珠腫による顔面神経麻痺症例の検討

  上原 奈津美, 下田 光, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一

  日本顔面神経学会, Jan. 2024, Facial Nerve Research, 43, 198 - 200, Japanese


• 中耳真珠腫による顔面神経麻痺症例の検討

  上原 奈津美, 下田 光, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一

  日本顔面神経学会, Jan. 2024, Facial Nerve Research, 43, 198 - 200, Japanese


• 当院で定めた成人両側人工内耳手術の選択基準の妥当性について

  岩城 忍, 柿木 章伸, 藤田 岳, 上原 奈津美, 横井 純, 丹生 健一

  (一社)日本聴覚医学会, Dec. 2023, Audiology Japan, 66(6) (6), 544 - 551, Japanese


• ミトコンドリアDNA変異症例の臨床的特徴と聴覚障害の検討

  上原 奈津美, 藤田 岳, 横井 純, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Nov. 2023, 日本耳科学会総会・学術講演会抄録集, 33回, 106 - 106, Japanese


• コハク酸脱水素酵素サブユニットB(SDHB)変異を伴った多発性頭頸部傍神経節腫の1例

  横井 純, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Nov. 2023, 日本耳科学会総会・学術講演会抄録集, 33回, 353 - 353, Japanese


• 外耳道に挿入する耳科内視鏡ロボットの初期位置を決める画像認識手法

  奥家 拓海, 河合 俊和, 西川 敦, 藤田 岳, 上原 奈津美, 山下 俊彦, 鈴木 寿

  (一社)日本コンピュータ外科学会, Nov. 2023, 日本コンピュータ外科学会誌, 25(3) (3), 165 - 165, Japanese


• 内視鏡下耳科手術支援ロボットの自律化に向けた深層学習を用いた複数手術器具検出

  丸川 可南子, 松居 和寛, 厚海 慶太, 藤田 岳, 上原 奈津美, 山下 俊彦, 河合 俊和, 鈴木 寿, 谷口 和弘, 平井 宏明, 西川 敦

  (一社)日本コンピュータ外科学会, Nov. 2023, 日本コンピュータ外科学会誌, 25(3) (3), 178 - 178, Japanese


• ピボット点を切り替える斜交関節を備えた耳科用内視鏡マニピュレータ

  伊澤 樹哉, 河合 俊和, 藤田 岳, 上原 奈津美, 山下 俊彦, 西川 敦, 鈴木 寿

  (一社)日本コンピュータ外科学会, Nov. 2023, 日本コンピュータ外科学会誌, 25(3) (3), 227 - 227, Japanese


• 内視鏡下耳科手術支援ロボット制御に向けた術者の姿勢・動作の画像解析

  西田 周誠, 松居 和寛, 厚海 慶太, 藤田 岳, 上原 奈津美, 山下 俊彦, 河合 俊和, 鈴木 寿, 谷口 和弘, 平井 宏明, 西川 敦

  (一社)日本コンピュータ外科学会, Nov. 2023, 日本コンピュータ外科学会誌, 25(3) (3), 242 - 242, Japanese


• 外耳癌 診断から治療・術後管理まで 耳科手術専門医が知っておきたい技術 外側側頭骨切除術の適応と実際

  藤田 岳

  (一社)日本耳科学会, Nov. 2023, 日本耳科学会総会・学術講演会抄録集, 33回, 39 - 39, Japanese


• ミトコンドリアDNA変異症例の臨床的特徴と聴覚障害の検討

  上原 奈津美, 藤田 岳, 横井 純, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Nov. 2023, 日本耳科学会総会・学術講演会抄録集, 33回, 106 - 106, Japanese


• コハク酸脱水素酵素サブユニットB(SDHB)変異を伴った多発性頭頸部傍神経節腫の1例

  横井 純, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Nov. 2023, 日本耳科学会総会・学術講演会抄録集, 33回, 353 - 353, Japanese


• 吸水性合成樹脂製玩具(水で膨らむボール)による外耳道異物の1例

  繁治 純, 藤田 岳, 安井 理絵

  日本小児耳鼻咽喉科学会, Oct. 2023, 小児耳鼻咽喉科, 44(2) (2), 308 - 308, Japanese


• ミトコンドリア病母体から出生した児の臨床症状に関する検討

  上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  日本小児耳鼻咽喉科学会, Oct. 2023, 小児耳鼻咽喉科, 44(2) (2), 332 - 332, Japanese


• 放射線誘発前庭障害をきたした外耳道癌症例

  横井 純, 山下 俊彦, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本めまい平衡医学会, Oct. 2023, Equilibrium Research, 82(5) (5), 505 - 505, Japanese


• 吸水性合成樹脂製玩具(水で膨らむボール)による外耳道異物の1例

  繁治 純, 藤田 岳, 安井 理絵

  日本小児耳鼻咽喉科学会, Oct. 2023, 小児耳鼻咽喉科, 44(2) (2), 308 - 308, Japanese


• ミトコンドリア病母体から出生した児の臨床症状に関する検討

  上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  日本小児耳鼻咽喉科学会, Oct. 2023, 小児耳鼻咽喉科, 44(2) (2), 332 - 332, Japanese


• 高齢者における人工内耳の装用効果

  岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Sep. 2023, Audiology Japan, 66(5) (5), 330 - 330, Japanese


• 腫瘍茎部が消失していた外耳道骨腫の1例

  中居 薫花, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  耳鼻咽喉科臨床学会, Jun. 2023, 耳鼻咽喉科臨床 補冊, (補冊161) (補冊161), 66 - 66, Japanese


• 人工内耳装用により認知機能検査のスコアが改善した高齢者の1例

  上坂 紗貴子, 岩城 忍, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  耳鼻咽喉科臨床学会, Jun. 2023, 耳鼻咽喉科臨床 補冊, (補冊161) (補冊161), 139 - 139, Japanese


• 日本耳鼻咽喉科頭頸部外科学会 働き方改革に関するWG報告 働き方改革に関するアンケート結果

  櫻井 結華, 藤田 岳, 森田 由香, 吉川 衛, 角南 貴司子, 小林 一女, 丹生 健一

  (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2023, 日本耳鼻咽喉科頭頸部外科学会会報, 126(4) (4), 555 - 555, Japanese


• 日耳鼻若手会員・基幹施設への出産・育児に関するアンケート調査結果(働き方改革に関するWG報告)

  藤田 岳, 森田 由香, 松延 毅, 丸山 裕美子, 櫻井 結華, 吉川 衛, 角南 貴司子, 小林 一女, 丹生 健一

  (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2023, 日本耳鼻咽喉科頭頸部外科学会会報, 126(4) (4), 555 - 555, Japanese


• Image recognition of external auditory canal for controlling ear endoscope robot

  奥家拓海, 河合俊和, 西川敦, 藤田岳, 上原奈津美, 山下俊彦, 鈴木寿

  2023, 日本機械学会ロボティクス・メカトロニクス講演会講演論文集(CD-ROM), 2023


• Image Recognition Method for Controlling Initial Position and Attitude of Ear Endoscope Robot Through into External Auditory Canal

  奥家拓海, 河合俊和, 西川敦, 藤田岳, 上原奈津美, 山下俊彦, 鈴木寿

  2023, 日本コンピュータ外科学会誌(Web), 25(3) (3)


• 両側同時人工内耳植込み術後の前庭機能について

  横井 純, 柳沢 俊学, 梶本 康幸, 岩城 忍, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本めまい平衡医学会, Oct. 2022, Equilibrium Research, 81(5) (5), 469 - 469, Japanese


• 人工聴覚器の適応:迷う症例にどう対応するか 人工中耳(VSB:Vibrant Soundbridge)に迷う症例

  藤田 岳

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 25 - 25, Japanese


• 耳科手術とQOLワーキンググループ 耳科手術とQOLに関する調査

  神崎 晶, 我那覇 章, 吉村 豪兼, 森田 由香, 松本 希, 藤田 岳, 白井 杏湖, 赤井 亮, 伊藤 吏, 土井 勝美, 高橋 優宏, 高橋 昌寛, 平海 晴一, 高橋 真理子, 岡田 昌浩, 山内 大輔, 美内 慎也, 山本 典生, 池園 哲郎, 小森 学, 綾仁 悠介, 樫尾 明憲, 細谷 誠, 宇佐美 真一, 東野 哲也, 中川 尚志, 萩森 伸一

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 73 - 73, Japanese


• 遅発性感音難聴患者における聴力型から見た遺伝学的背景の検討

  上原 奈津美, 藤田 岳, 横井 純, 西尾 信哉, 宇佐美 真一, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 138 - 138, Japanese


• ミトコンドリアDNA7445A>G変異による難聴及び掌蹠角化症を認めた2例

  稲田 幸歩, 上原 奈津美, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 170 - 170, Japanese


• 聴力改善手術が患者QOLに及ぼす影響 邦訳版QOL質問票(SF36,SSQ12,COMQ12,SPOT25,NCIQ)を用いた検討(第2報)

  村田 大和, 細谷 誠, 我那覇 章, 吉村 豪兼, 森田 由香, 松本 希, 藤田 岳, 白井 杏湖, 赤井 亮, 伊藤 吏, 土井 勝美, 高橋 優宏, 高橋 昌寛, 平海 晴一, 高橋 真理子, 岡田 昌浩, 山内 大輔, 美内 慎也, 山本 典生, 池園 哲郎, 小森 学, 綾仁 悠介, 樫尾 明憲, 宇佐美 真一, 東野 哲也, 中川 尚志, 萩森 伸一, 神崎 晶

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 290 - 290, Japanese


• 中耳髄膜腫の一例

  庄司 夢, 上原 奈津美, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 309 - 309, Japanese


• 経外耳道的内視鏡下手術(TEES)で摘出し得たグロムス腫瘍症例

  小西池 佑一, 藤田 岳, 横井 純, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 310 - 310, Japanese


• 手術とデノスマブによるアジュバント療法を施行した側頭骨骨巨細胞腫の1例

  横井 純, 柿木 章伸, 上原 奈津美, 藤田 岳, 丹生 健一

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 393 - 393, Japanese


• 成人における両側人工内耳手術の適応に関する検討(第一報)

  岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Sep. 2022, Audiology Japan, 65(5) (5), 430 - 430, Japanese


• 内視鏡下耳科手術支援ロボット制御のための深層学習を用いた手術器具セグメンテーション

  堀ノ内 琢磨, 松居 和寛, 厚海 慶太, 藤田 岳, 上原 奈津美, 山下 俊彦, 河合 俊和, 鈴木 寿, 谷口 和弘, 平井 宏明, 西川 敦

  (一社)日本コンピュータ外科学会, Jun. 2022, 日本コンピュータ外科学会誌, 24(2) (2), 126 - 126, Japanese


• ニボルマブによるStevens-Johnson症候群の1例

  廣田 菜々子, 鈴木 緑, 加藤 麻衣子, 柳原 茂人, 遠藤 英樹, 大磯 直毅, 川田 暁, 大塚 篤司, 田中 薫, 藤田 岳

  日本皮膚科学会-大阪地方会・京滋地方会, Mar. 2022, 皮膚の科学, 21(1) (1), 1 - 5, Japanese


• A case of facial schwannoma with extensive destruction and infiltration of the temporal bone: Strategies and challenges for radical resection

  下田光, 柿木章伸, 横井純, 上原奈津美, 藤田岳, 橋川和信, 木村英仁, 丹生健一

  日本顔面神経学会, 2022, Facial Nerve Research Japan, 41, 59 - 61, Japanese


• 低侵襲人工内耳植込み術後の前庭機能について(第3報)

  横井 純, 柳沢 俊学, 梶本 康幸, 岩城 忍, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本めまい平衡医学会, Oct. 2021, Equilibrium Research, 80(5) (5), 482 - 482, Japanese


• 人工聴覚器手術 症例登録システムWG 2021年度活動報告

  土井 勝美, 岩崎 聡, 大崎 康宏, 伊藤 卓, 白井 杏湖, 藤田 岳, 吉田 晴郎, 新規医療委員会人工聴覚器手術-症例登録システムWG

  (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 122 - 122, Japanese


• 耳科手術とQOLに関する調査

  神崎 晶, 細谷 誠, 我那覇 章, 吉村 豪兼, 森田 由香, 松本 希, 藤田 岳, 白井 杏湖, 赤井 亮, 伊藤 吏, 土井 勝美, 高橋 優宏, 高橋 昌寛, 平海 晴一, 高橋 真理子, 岡田 昌浩, 山内 大輔, 美内 慎也, 山本 典生, 池園 哲郎, 小森 学, 綾仁 悠介, 樫尾 明憲, 宇佐美 真一, 東野 哲也, 中川 尚志, 萩森 伸一, 国内学術委員会耳科手術とQOLワーキンググループ

  (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 125 - 125, Japanese


• 一側性聴神経腫瘍症例における蝸牛内のMRI信号強度

  藤田 岳, 横井 純, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 187 - 187, Japanese


• 当科におけるグロムス腫瘍18例の治療方針の検討

  横井 純, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 199 - 199, Japanese


• ミトコンドリアDNA3243A>G変異によるミトコンドリア病の1家系

  上原 奈津美, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 265 - 265, Japanese


• 聴力改善手術が患者QOLに及ぼす影響 邦訳版QOL質問票(SF36、SSQ12、COMQ12、SPOT25、NCIQ)を用いた検討

  西村 洸一郎, 細谷 誠, 我那覇 章, 森田 由香, 松本 希, 吉村 豪兼, 藤田 岳, 白井 杏湖, 赤井 亮, 伊藤 吏, 土井 勝美, 高橋 優宏, 高橋 昌寛, 平海 晴一, 高橋 真理子, 岡田 昌浩, 山内 大輔, 美内 慎也, 山本 典生, 池園 哲郎, 小森 学, 綾仁 悠介, 樫尾 明憲, 宇佐美 真一, 東野 哲也, 中川 尚志, 萩森 伸一, 神崎 晶

  (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 269 - 269, Japanese


• キヌタ骨が乳突洞内に脱出した外傷性耳小骨離断の1例

  遠藤 侑未, 上原 奈津美, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 385 - 385, Japanese


• 高齢者における人工内耳装用後の聴取成績の経過について

  岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Sep. 2021, Audiology Japan, 64(5) (5), 466 - 466, Japanese


• 色素性乾皮症の聴力障害

  藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  日本小児耳鼻咽喉科学会, Jun. 2021, 小児耳鼻咽喉科, 42(2) (2), 163 - 163, Japanese


• Pseudo-dominant遺伝形式を示すGJB2遺伝子変異が検出された先天性難聴児の1例

  橋本 裕依子, 上原 奈津美, 岩城 忍, 藤田 岳, 柿木 章伸, 丹生 健一

  日本小児耳鼻咽喉科学会, Jun. 2021, 小児耳鼻咽喉科, 42(2) (2), 190 - 190, Japanese


• 好酸球中耳炎の中耳貯留液における脂質メディエーターの解析

  藤田 岳, 横井 純, 上原 奈津美, 井之口 豪, 後藤 友佳子, 土井 勝美, 柿木 章伸, 篠原 正和, 丹生 健一

  (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2021, 日本耳鼻咽喉科学会会報, 124(4) (4), 605 - 605, Japanese


• ミトコンドリア病による成人難聴症例の検討

  上原 奈津美, 藤田 岳, 横井 純, 柿木 章伸, 丹生 健一

  (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2021, 日本耳鼻咽喉科学会会報, 124(4) (4), 639 - 639, Japanese


• 【術前画像と術中解剖-カンファレンスで突っ込まれないための知識】耳領域 耳介・外耳道病変に対する手術

  藤田 岳, 柿木 章伸

  (株)医学書院, Apr. 2021, 耳鼻咽喉科・頭頸部外科, 93(5) (5), 006 - 011, Japanese


• 当科における顔面神経鞘腫23例の検討

  下田 光, 柿木 章伸, 横井 純, 上原 奈津美, 藤田 岳, 丹生 健一, 橋川 和信, 甲村 英二

  日本顔面神経学会, Mar. 2021, Facial Nerve Research, 40, 197 - 201, Japanese


• 低侵襲人工内耳埋め込み術後の前庭機能について

  横井 純, 柳沢 俊学, 柿木 章伸, 藤田 岳, 岩城 忍, 梶本 康幸, 丹生 健一

  (一社)日本めまい平衡医学会, Feb. 2021, Equilibrium Research, 80(1) (1), 31 - 40, Japanese


• 経外耳道的直達外傷による小児迷路気腫の1例

  上紺屋 達彦, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  日本小児耳鼻咽喉科学会, Nov. 2020, 小児耳鼻咽喉科, 41(2) (2), 202 - 202, Japanese


• 外側側頭骨切除術時に皮膚管を用いた一期的外耳道・伝音再建

  藤田 岳, 横井 純, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Nov. 2020, 日本耳科学会総会・学術講演会抄録集, 30回, 164 - 164, Japanese


• 成人症例における難聴遺伝子解析の検討

  上原 奈津美, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一, 西尾 信哉, 宇佐美 真一

  (一社)日本耳科学会, Nov. 2020, 日本耳科学会総会・学術講演会抄録集, 30回, 277 - 277, Japanese


• 人工内耳埋め込み術後の重心動揺検査の検討(第一報)

  横井 純, 柳沢 俊学, 柿木 章伸, 岩城 忍, 藤田 岳, 丹生 健一

  (一社)日本めまい平衡医学会, Oct. 2020, Equilibrium Research, 79(5) (5), 456 - 456, Japanese


• ステロイド加療を行い一時的に聴力が改善した聴神経腫瘍症例の検討

  白石 功, 小山 一, 藤田 岳, 齋藤 和也, 大崎 康宏, 土井 勝美

  (一社)日本耳科学会, Oct. 2019, 日本耳科学会総会・学術講演会抄録集, 29回, 444 - 444, Japanese


• 色素性乾皮症の聴力障害とモデルマウスの聴覚解析

  藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2019, 日本耳科学会総会・学術講演会抄録集, 29回, 471 - 471, Japanese


• 音響障害よる内耳外リンパのサイトカインの変化

  藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Oct. 2019, Audiology Japan, 62(5) (5), 441 - 441, Japanese


• 人工知能を用いた術後聴力予測システムの開発

  小山 一, 奥野 妙子, 畑 裕子, 森 安仁, 齋藤 和也, 大崎 康宏, 藤田 岳, 山岨 達也, 土井 勝美

  (一社)日本耳科学会, Oct. 2019, 日本耳科学会総会・学術講演会抄録集, 29回, 111 - 111, Japanese


• TEESが有用であった両側先天性真珠腫に対する同時手術の2例

  上田 隆, 由井 光子, 赤澤 亜由, 上原 奈津美, 藤田 岳, 後藤 友佳子, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2019, 日本耳科学会総会・学術講演会抄録集, 29回, 207 - 207, Japanese


• ステロイド加療を行い一時的に聴力が改善した聴神経腫瘍症例の検討

  白石 功, 小山 一, 藤田 岳, 齋藤 和也, 大崎 康宏, 土井 勝美

  (一社)日本耳科学会, Oct. 2019, 日本耳科学会総会・学術講演会抄録集, 29回, 444 - 444, Japanese


• 色素性乾皮症の聴力障害とモデルマウスの聴覚解析

  藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2019, 日本耳科学会総会・学術講演会抄録集, 29回, 471 - 471, Japanese


• 音響障害よる内耳外リンパのサイトカインの変化

  藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Oct. 2019, Audiology Japan, 62(5) (5), 441 - 441, Japanese


• 両側同時人工内耳植え込み術を施行した両側内耳破壊の一症例

  岩城 忍, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Oct. 2019, Audiology Japan, 62(5) (5), 502 - 502, Japanese


• 【聴神経腫瘍診療の未来】聴神経腫瘍の基礎研究と遺伝子解析

  藤田 岳, 土井 勝美

  (一社)日本耳科学会, May 2019, Otology Japan, 29(2) (2), 137 - 141, Japanese


• 前庭神経機能の評価におけるカロリック検査、vHIT検査およびVEMP検査の関連性について

  白石 功, 小林 孝光, 藤田 岳, 瀬尾 徹, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2019, 日本耳鼻咽喉科学会会報, 122(4) (4), 652 - 652, Japanese


• VSB術後成績における予後因子の検討

  小山 一, 藤田 岳, 齋藤 和也, 大崎 康宏, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2019, 日本耳鼻咽喉科学会会報, 122(4) (4), 643 - 643, Japanese


• 前庭神経機能の評価におけるカロリック検査、vHIT検査およびVEMP検査の関連性について

  白石 功, 小林 孝光, 藤田 岳, 瀬尾 徹, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2019, 日本耳鼻咽喉科学会会報, 122(4) (4), 652 - 652, Japanese


• 当科における小児先天性耳小骨奇形の検討

  齋藤 和也, 小林 孝光, 藤田 岳, 土井 勝美

  日本小児耳鼻咽喉科学会, Jun. 2018, 小児耳鼻咽喉科, 39(2) (2), 158 - 158, Japanese


• 残存聴力活用型人工内耳(EAS)適応聴力患者の検討

  齋藤 和也, 堀口 生茄, 小林 孝光, 佐藤 満雄, 藤田 岳, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2018, 日本耳鼻咽喉科学会会報, 121(4) (4), 522 - 522, Japanese


• メニエール病におけるカロリックテストとvHITの結果の乖離に関する検討

  瀬尾 徹, 小林 孝光, 白石 功, 藤田 岳, 北野 睦三, 齋藤 和也, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2018, 日本耳鼻咽喉科学会会報, 121(4) (4), 561 - 561, Japanese


• 一側聾となった前庭内の小聴神経鞘腫の1例

  佐藤 満雄, 藤田 岳, 齋藤 和也, 瀬尾 徹, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2018, 日本耳鼻咽喉科学会会報, 121(4) (4), 617 - 617, Japanese


• 人工内耳埋め込み術後に生じた顔面痙攣の検討

  齋藤 和也, 小林 孝光, 藤田 岳, 土井 勝美

  日本顔面神経学会, Feb. 2018, Facial Nerve Research, 37, 98 - 100, Japanese


• 人工内耳埋め込み術後に生じた顔面痙攣の検討

  齋藤 和也, 小林 孝光, 藤田 岳, 土井 勝美

  日本顔面神経学会, Feb. 2018, Facial Nerve Research, 37, 98 - 100, Japanese


• 上前庭神経障害の評価に関する検討

  白石 功, 瀬尾 徹, 小林 孝光, 藤田 岳, 土井 勝美

  (一社)日本めまい平衡医学会, Oct. 2017, Equilibrium Research, 76(5) (5), 486 - 486, Japanese


• めまいと難聴を主訴とした小脳悪性リンパ腫の1例

  白石 功, 藤田 岳, 小林 孝光, 瀬尾 徹, 土井 勝美

  (一社)日本めまい平衡医学会, Oct. 2017, Equilibrium Research, 76(5) (5), 546 - 546, Japanese


• メニエール病非定型例(蝸牛型)の病態に関する考察 フロセミド負荷VEMPによる検討

  瀬尾 徹, 白石 功, 小林 功, 藤田 岳, 斎藤 和也, 土井 勝美

  (一社)日本耳科学会, Oct. 2017, Otology Japan, 27(4) (4), 505 - 505, Japanese


• 鼓膜形成後の聴力経過 術式による違い

  齋藤 和也, 磯野 道夫, 小林 孝光, 藤田 岳, 土井 勝美

  (一社)日本耳科学会, Oct. 2017, Otology Japan, 27(4) (4), 601 - 601, Japanese


• 中耳奇形に合併した内耳瘻孔例

  小林 孝光, 藤田 岳, 齋藤 和也, 磯野 道夫, 瀬尾 徹, 土井 勝美

  (一社)日本耳科学会, Oct. 2017, Otology Japan, 27(4) (4), 637 - 637, Japanese


• 突発性難聴患者に聴神経腫瘍が発見された頻度

  藤田 岳, 齋藤 和也, 瀬尾 徹, 土井 勝美

  (一社)日本耳科学会, Oct. 2017, Otology Japan, 27(4) (4), 657 - 657, Japanese


• 術後MRSA感染により再手術をおこなった人工内耳症例

  森川 大樹, 藤田 岳, 齋藤 和也, 土井 勝美

  日本耳鼻咽喉科感染症・エアロゾル学会, Sep. 2017, 日本耳鼻咽喉科感染症・エアロゾル学会会誌, 5(3) (3), 66 - 66, Japanese


• 人工内耳電極の長さの違いによる、低周波数域の聴力温存の検討

  藤田 岳, 齋藤 和也, 土井 勝美

  (一社)日本聴覚医学会, Sep. 2017, Audiology Japan, 60(5) (5), 291 - 291, Japanese


• 当科におけるVIBRANT SOUNDBRIDGE(VSB)装用患者の聴取成績経過

  長富 大祐, 藤田 岳, 齋藤 和也, 土井 勝美

  (一社)日本聴覚医学会, Sep. 2017, Audiology Japan, 60(5) (5), 317 - 317, Japanese


• 耳鳴に対し補聴器による音響療法を行った9例

  小林 孝光, 藤田 岳, 齋藤 和也, 新田 清一, 土井 勝美

  (一社)日本聴覚医学会, Sep. 2017, Audiology Japan, 60(5) (5), 403 - 403, Japanese


• いわゆるlight cupula症の耳石器機能

  瀬尾 徹, 白石 功, 小林 孝光, 藤田 岳, 北野 睦三, 土井 勝美

  耳鼻咽喉科ニューロサイエンス研究会, May 2017, 耳鼻咽喉科ニューロサイエンス, 31, 13 - 15, Japanese


• いわゆるlight cupula症の耳石器機能

  瀬尾 徹, 白石 功, 小林 孝光, 藤田 岳, 北野 睦三, 土井 勝美

  耳鼻咽喉科ニューロサイエンス研究会, May 2017, 耳鼻咽喉科ニューロサイエンス, 31, 13 - 15, Japanese


• 外耳道経由で正円窓へのアプローチを目指した、ヒト側頭骨標本の解剖学的検討

  藤田 岳, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2017, 日本耳鼻咽喉科学会会報, 120(4) (4), 522 - 522, Japanese


• 当科で経験した残存聴力活用型人工内耳手術症例の成績

  齋藤 和也, 小林 孝光, 白石 功, 西原 美沙子, 佐藤 満雄, 藤田 岳, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2017, 日本耳鼻咽喉科学会会報, 120(4) (4), 526 - 526, Japanese


• 耳石器障害めまい患者の重心動揺

  小林 孝光, 白石 功, 藤田 岳, 齋藤 和也, 瀬尾 徹, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2017, 日本耳鼻咽喉科学会会報, 120(4) (4), 667 - 667, Japanese


• 外耳道経由で正円窓へのアプローチを目指した、ヒト側頭骨標本の解剖学的検討

  藤田 岳, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2017, 日本耳鼻咽喉科学会会報, 120(4) (4), 522 - 522, Japanese


• 当科で経験した残存聴力活用型人工内耳手術症例の成績

  齋藤 和也, 小林 孝光, 白石 功, 西原 美沙子, 佐藤 満雄, 藤田 岳, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2017, 日本耳鼻咽喉科学会会報, 120(4) (4), 526 - 526, Japanese


• 耳石器障害めまい患者の重心動揺

  小林 孝光, 白石 功, 藤田 岳, 齋藤 和也, 瀬尾 徹, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2017, 日本耳鼻咽喉科学会会報, 120(4) (4), 667 - 667, Japanese


• いわゆるlight cupula型頭位眼振症例の耳石器機能

  藤田 岳, 瀬尾 徹, 白石 功, 小林 孝光, 北野 睦三, 土井 勝美

  (一社)日本めまい平衡医学会, Oct. 2016, Equilibrium Research, 75(5) (5), 436 - 436, Japanese


• 児の感染を契機に発覚した両親の咽頭梅毒

  森川 大樹, 齋藤 和也, 藤田 岳, 土井 勝美

  日本耳鼻咽喉科感染症・エアロゾル学会, Sep. 2016, 日本耳鼻咽喉科感染症・エアロゾル学会会誌, 4(3) (3), 54 - 54, Japanese


• 人工内耳埋め込み術をおこなったOMAAVの一例

  齋藤 和也, 小林 孝光, 佐藤 満雄, 藤田 岳, 小泉 敏三, 土井 勝美

  (一社)日本聴覚医学会, Sep. 2016, Audiology Japan, 59(5) (5), 363 - 364, Japanese


• フロセミド負荷VEMP メニエール病のめまい発作の発現機序に関する考察

  瀬尾 徹, 白石 功, 小林 孝光, 藤田 岳, 小泉 敏三, 齋藤 和也, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 287 - 287, Japanese


• 当院におけるパッチテストと鼓膜形成術について

  齋藤 和也, 磯野 道夫, 小林 孝光, 佐藤 満雄, 藤田 岳, 小泉 敏三, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 362 - 362, Japanese


• 聴神経腫瘍から分泌される細胞外小胞(エクソソーム)による蝸牛障害

  藤田 岳, 柿木 章伸, 丹生 健一, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 482 - 482, Japanese


• 顔面神経減荷術施行34症例の検討

  小泉 敏三, 齋藤 和也, 小林 孝光, 藤田 岳, 磯野 道夫, 瀬尾 徹, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 598 - 598, Japanese


• 当科におけるウイルス性を除いた顔面神経麻痺症例の検討

  木村 隆幸, 藤田 岳, 小泉 敏三, 齋藤 和也, 磯野 道夫, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 601 - 601, Japanese


• 高度難聴が著明に改善した外リンパ瘻の1例

  小林 孝光, 藤田 岳, 齋藤 和也, 小泉 敏三, 瀬尾 徹, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 619 - 619, Japanese


• フロセミド負荷VEMP メニエール病のめまい発作の発現機序に関する考察

  瀬尾 徹, 白石 功, 小林 孝光, 藤田 岳, 小泉 敏三, 齋藤 和也, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 287 - 287, Japanese


• 当院におけるパッチテストと鼓膜形成術について

  齋藤 和也, 磯野 道夫, 小林 孝光, 佐藤 満雄, 藤田 岳, 小泉 敏三, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 362 - 362, Japanese


• 聴神経腫瘍から分泌される細胞外小胞(エクソソーム)による蝸牛障害

  藤田 岳, 柿木 章伸, 丹生 健一, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 482 - 482, Japanese


• 顔面神経減荷術施行34症例の検討

  小泉 敏三, 齋藤 和也, 小林 孝光, 藤田 岳, 磯野 道夫, 瀬尾 徹, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 598 - 598, Japanese


• 当科におけるウイルス性を除いた顔面神経麻痺症例の検討

  木村 隆幸, 藤田 岳, 小泉 敏三, 齋藤 和也, 磯野 道夫, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 601 - 601, Japanese


• 高度難聴が著明に改善した外リンパ瘻の1例

  小林 孝光, 藤田 岳, 齋藤 和也, 小泉 敏三, 瀬尾 徹, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 619 - 619, Japanese


• Dab1遺伝子異常マウスにおけるオリーブ蝸牛束の構築異常の解明

  井之口 豪, 薛 富義, 吉川 知志, 寺島 俊雄, 四宮 瞳, 藤田 岳, 山下 大介, 丹生 健一

  耳鼻咽喉科ニューロサイエンス研究会, May 2016, 耳鼻咽喉科ニューロサイエンス, 30, 20 - 22, Japanese


• Dab1遺伝子異常マウスにおけるオリーブ蝸牛束の構築異常の解明

  井之口 豪, 薛 富義, 吉川 知志, 寺島 俊雄, 四宮 瞳, 藤田 岳, 山下 大介, 丹生 健一

  耳鼻咽喉科ニューロサイエンス研究会, May 2016, 耳鼻咽喉科ニューロサイエンス, 30, 20 - 22, Japanese


• 耳下腺上皮筋上皮癌の2例

  小嶋 康隆, 雲井 一夫, 井之口 豪, 小松 弘和, 藤田 岳, 澤田 直樹, 栃谷 奈央, 甲藤 麻衣, 橋本 公夫

  (一社)日本耳鼻咽喉科学会, Apr. 2016, 日本耳鼻咽喉科学会会報, 119(4) (4), 675 - 675, Japanese


• 前庭症状を主訴とした症例での簡易温度刺激検査の年代別検討

  Inokuchi Gou, Fujita Takeshi

  Nov. 2015, 第73回日本めまい平衡医学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 外耳道後壁削除型鼓室形成術に併施した骨パテによる乳突腔部分充填術後症例の検討

  上原 奈津美, 後藤 友佳子, 長谷川 信吾, 香山 智佳子, 越智 尚樹, 藤田 岳, 小嶋 康隆, 山本 沙織

  (一社)日本耳科学会, Sep. 2015, Otology Japan, 25(4) (4), 635 - 635, Japanese


• 耳かきによる外傷性耳小骨離断の陳旧例2症例

  畑 裕子, 堤内 亮博, 山本 沙織, 藤田 岳, 一瀬 和美, 立川 麻也子, 宇野 真莉子, 松本 有, 小嶋 康隆, 奥野 妙子

  (一社)日本耳科学会, Jul. 2015, Otology Japan, 25(3) (3), 260 - 268, Japanese


• 軟素材による外耳道後壁再建を行った後天性真珠腫症例の検討

  柴田 智久, 藤田 岳, 小嶋 康隆, 井之口 豪, 山下 大介, 長谷川 信吾, 丹生 健一

  (一社)日本耳鼻咽喉科学会, Apr. 2015, 日本耳鼻咽喉科学会会報, 118(4) (4), 482 - 482, Japanese


• 前庭症状を主訴とした症例での簡易温度刺激検査の年代別検討

  畑 裕子, 山崎 葉子, 堤内 亮博, 山本 沙織, 崎谷 恵理, 一瀬 和美, 馬場 美雪, 松本 有, 小嶋 康隆, 井之口 豪, 藤田 岳, 奥野 妙子

  (一社)日本めまい平衡医学会, Oct. 2014, Equilibrium Research, 73(5) (5), 400 - 400, Japanese


• 色素性乾皮症における聴覚障害の検討

  Yamashita Daisuke, Fujita Takeshi, Inokuchi Gou, Hasegawa Shingo, Nibu Ken-ichi

  Oct. 2014, 第24回日本耳科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 溶連菌による成人急性中耳炎の2症例

  Fujita Takeshi

  Oct. 2014, 第24回日本耳科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 色素性乾皮症における聴覚障害の検討

  山下 大介, 藤田 岳, 井之口 豪, 長谷川 信吾, 丹生 健一

  (一社)日本耳科学会, Sep. 2014, Otology Japan, 24(4) (4), 487 - 487, Japanese


• 溶連菌による成人急性中耳炎の2症例

  畑 裕子, 堤内 亮博, 山本 沙織, 崎谷 恵理, 藤田 岳, 一瀬 和美, 奥野 妙子

  (一社)日本耳科学会, Sep. 2014, Otology Japan, 24(4) (4), 670 - 670, Japanese


• 前庭症状を主訴とした症例の年代別特徴について(第2報)

  Fujita Takeshi

  May 2014, 第115回日本耳鼻咽喉科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 中耳真珠腫における乳突蜂巣発育程度および含気腔

  Fujita Takeshi

  May 2014, 第115回日本耳鼻咽喉科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 先天性真珠腫の成人例

  Inokuchi Gou, Fujita Takeshi

  May 2014, 第115回日本耳鼻咽喉科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 耳下腺に浸潤した外毛根鞘癌の一例

  Inokuchi Gou, Komatsu Hirokazu, Fujita Takeshi

  May 2014, 第115回日本耳鼻咽喉科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 中耳真珠腫進展度分類2010改訂案中のアブミ骨病変の程度に基づいた真珠腫性中耳炎自験例の検討

  Fujita Takeshi

  May 2014, 第115回日本耳鼻咽喉科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 手術治療が有効であったPlummer病の1例

  Fujita Takeshi, Inokuchi Gou

  May 2014, 第115回日本耳鼻咽喉科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• Hearing loss in Xeroderma pigmnetosum and mechanism of inner ear disorder.

  Yamashita Daisuke, Fujita Takeshi, Masaki Taro, Takeuchi Seiji, Ueda Takehiro, Sakai Yoshitada, Nakagawa Taku, Toyoshima Daisaku, Morisada Naoya, Kanda Fumio, Nishigori Chikako

  Mar. 2014, International Symposium on Xeroderma Pigmentosum and Related Disease, English

  Summary national conference


• 乳突蜂巣内を走行するpetrosquamosal sinus

  Inokuchi Gou, Komatsu Hirokazu, Fujita Takeshi

  Nov. 2013, The 23th Annual Meeting of the Japan Otological Society, Japanese

  [Invited]

  Summary national conference


• 【急患・急変対応マニュアル-そのとき必要な処置と処方】 術中・術後の急変への対応法 術後編 耳科手術後の髄液漏

  藤田 岳, 奥野 妙子

  (株)医学書院, Apr. 2013, 耳鼻咽喉科・頭頸部外科, 85(5) (5), 332 - 335, Japanese


• AIDS患者の中咽頭扁平上皮癌に対する治療経験

  Fujita Takeshi, Yoshida Kenji, Sasaki Ryohei, Ohtsuki Naoki, Nibu Ken-ichi

  Jun. 2012, 第36回日本頭頸部癌学会, Japanese

  [Invited]

  Summary national conference


• 患者の中咽頭扁平上皮癌に対する治療経験

  林 拓二, 藤田 岳, 吉田 賢史, 西村 英輝, 佐々木 良平, 大月 直樹, 丹生 健一

  (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 224 - 224, Japanese


• 内耳移植細胞の生体内動態モニタリング法の確立

  山下 大介, 和多田 有紀子, 神崎 晶, 藤田 岳, 長谷川 信吾, 小川 郁, 丹生 健一

  耳鼻咽喉科ニューロサイエンス研究会, Apr. 2011, 頭頸部自律神経, 25, 7 - 9, Japanese


• 糖尿病モデルマウスにおける聴覚機能および内耳形態の検討

  藤田 岳, 山下 大介, 勝沼 紗矢香, 長谷川 信吾, 丹生 健一

  耳鼻咽喉科ニューロサイエンス研究会, Apr. 2011, 頭頸部自律神経, 25, 13 - 16, Japanese


• 音響外傷性難聴に対するSA4503の内耳防御機能

  山下 大介, 松永 達雄, 藤田 岳, 長谷川 信吾, 丹生 健一

  (一社)日本耳鼻咽喉科学会, Apr. 2010, 日本耳鼻咽喉科学会会報, 113(4) (4), 396 - 396, Japanese


• 小児口蓋扁桃摘出術における予防的抗菌薬投与の検討 抗菌薬術前単回投与と術後7日間投与の比較

  藤田 岳, 後藤 友佳子, 香山 智佳子, 長谷川 信吾, 丹生 健一

  日本小児耳鼻咽喉科学会, Mar. 2010, 小児耳鼻咽喉科, 31(1) (1), 76 - 81, Japanese


• 小児口蓋扁桃摘出術における予防的抗菌薬投与の検討 : 術後7日間投与と術前1回投与の比較

  藤田 岳, 後藤 友佳子, 松元 雪絵, 越智 尚樹, 香山 智佳子, 小嶋 康隆, 長谷川 信吾, 丹生 健一

  01 Jun. 2009, 小児耳鼻咽喉科, 30(2) (2), 96 - 96, Japanese


• 小児上咽頭分離菌と反復性中耳炎症例の検討

  香山 智佳子, 後藤 友佳子, 越智 尚樹, 小嶋 康隆, 藤田 岳, 中上 佳美

  日本耳鼻咽喉科感染症研究会, May 2009, 日本耳鼻咽喉科感染症研究会会誌, 27(1) (1), 117 - 121, Japanese


• Seven cases of adhesive cholesteatoma in children

  GOTO Yukako, OCHI Naoki, KAYAMA Chikako, HASEGAWA Shingo, FUJITA Takeshi, KOJIMA Yasutaka

  01 Mar. 2009, 小児耳鼻咽喉科, 30(1) (1), 54 - 60, Japanese


• 小児癒着型真珠腫症例の検討

  後藤 友佳子, 越智 尚樹, 小嶋 康隆, 香山 智佳子, 長谷川 信吾, 藤田 岳

  21 Jun. 2008, 小児耳鼻咽喉科, 29(2) (2), 44 - 44, Japanese


• 小児反復性中耳炎難治例

  香山 智佳子, 後藤 友佳子, 越智 尚樹, 小嶋 康隆, 藤田 岳

  21 Jun. 2008, 小児耳鼻咽喉科, 29(2) (2), 59 - 59, Japanese


• 口蓋扁桃摘出術における予防的抗菌薬投与の検討 術後5日間投与から術直前投与への変更

  藤田 岳, 後藤 友佳子, 越智 尚樹, 香山 智佳子

  日本耳鼻咽喉科感染症研究会, May 2008, 日本耳鼻咽喉科感染症研究会会誌, 26(1) (1), 163 - 166, Japanese


• 好酸球性中耳炎の聴力予後

  後藤 友佳子, 越智 尚樹, 藤田 岳, 香山 智佳子, 濱本 由記子, 長谷川 信吾

  22 Sep. 2007, Otology Japan, 17(4) (4), 449 - 449, Japanese


• 両側難聴と視力障害を呈したクリプトコッカス髄膜炎の一例

  藤田 岳, 後藤 友佳子, 越智 尚樹, 香山 智佳子

  22 Sep. 2007, Otology Japan, 17(4) (4), 383 - 383, Japanese


• 側頭部から頸部まで進展した咀嚼筋間隙膿瘍の一例

  藤田 岳, 後藤 友佳子, 長谷川 信吾, 下屋 聡子, 香山 智佳子

  日本耳鼻咽喉科感染症研究会, May 2007, 日本耳鼻咽喉科感染症研究会会誌, 25(1) (1), 93 - 96, Japanese


• 難治性MRSA感染耳に対するピオクタニン^【○!R】の治療経験

  香山 智佳子, 後藤 友佳子, 長谷川 信吾, 藤田 岳

  22 Sep. 2006, Otology Japan, 16(4) (4), 432 - 432, Japanese


• 鼓膜チューブ留置術による治療成績と合併症について : チューブ留置期間による検討

  長谷川 信吾, 後藤 友佳子, 藤田 岳, 香山 智佳子

  22 Sep. 2006, Otology Japan, 16(4) (4), 347 - 347, Japanese


• 好酸球性中耳炎に対するトリアムシノロンアセトニド(ケナコルトーA^【○!R】)中耳腔内投与の効果

  後藤 友佳子, 長谷川 信吾, 藤田 岳, 香山 智佳子

  22 Sep. 2006, Otology Japan, 16(4) (4), 389 - 389, Japanese

• Hearing Impairment in Xeroderma Pigmentosum: Animal Models and Human Studies

  FUJITA TAKESHI

  Joint work, 49-58, Springer Singapore, 2019, English

  Scholarly book

• テラヘルツ波を用いた甲状腺腫瘍に対する革新的診断技術の確立

  手島 直則, 芹田 和則, 上原 慶一郎, 藤田 岳

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2024 - 31 Mar. 2028


• 医工融合による低侵襲・高解像な感音難聴の精密診断の実現

  藤田 岳

  科学技術振興機構, 戦略的な研究開発の推進 創発的研究支援事業, 神戸大学, Apr. 2022 - 2028, Principal investigator

  空気の振動である「音」は、耳の奥にある内耳蝸牛で電気的な信号に変換されます。この蝸牛が障害されることにより、感音難聴が生じます。しかし、生きている人の蝸牛内部を直接観察する技術は存在せず、現在でも、目の前の患者さんの感音難聴の原因は分かりません。本研究では外科的な技能・知識と工学的テクノロジーの融合により、感音難聴の原因をリアルタイムに診断し、治療につながる画期的な技術の開発を目指します。


• The role of MMP14 in Vestibular Schwannoma and the development of novel treatments and diagnostic methods

  百束 紘, 大石 直樹, 和佐野 浩一郎, 都築 伸佳, 藤田 岳, 荒井 康裕

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Yokohama City University, Apr. 2024 - Mar. 2027


• a

  西川 敦, 藤田 岳, 西澤祐吏, 河合俊和, 鈴木 寿

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Osaka University, Apr. 2022 - Mar. 2027, Coinvestigator


• 一側性および非対称性難聴に対する雑音下語音聴取評価検査に係る至適条件の探索

  山田 悠祐, 松田 悠佑, 東野 哲也, 高橋 優宏, 岩崎 聡, 大石 直樹, 鬼頭 良輔, 中西 啓, 柿木 章伸, 藤田 岳, 石野 岳志, 吉田 忠雄, 菅原 一真, 實川 純人

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 国際医療福祉大学, 01 Apr. 2023 - 31 Mar. 2026


• 脂質メディエーターに着目した好酸球中耳炎の感音難聴メカニズム解明と治療法探索

  藤田 岳

  日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2022 - 31 Mar. 2026


• Analysis of Cancer-Associated Genes using Next-Generation Sequencing in Vestibular Schwannomas

  Fujita Takeshi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2019 - 31 Mar. 2022, Principal investigator

  Vestibular schwannoma (VS) is the most common tumor of the cerebellopontine angle. The number of sporadic VS cases has increased rapidly over the last decade. Here, we completed a comprehensive genomic analysis of all the exons in the key tumor suppressor and oncogenes from small (< 15mm) sporadic VS samples. These evaluations identified NF2, SYNE1, IRS2, APC, CIC, SDHC, BRAF, NUMA1, EXT2, HRAS, BCL11B, MAGI1, RNF123, NLRP1, ASXL1, ADAMTS20, TAF1L, XPC, DDB2, and ETS1 as mutated genes and novel missense mutations in the SYNE1 transcript were identified in 20% of the samples.

  Competitive research funding


• The molecular mechanism of hearing loss in acoustic neuroma patients.

  Fujita Takeshi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), 01 Apr. 2017 - 31 Mar. 2019, Principal investigator

  The aim of this study is to elucidate the mechanism of hearing loss and tumor growth in acoustic neuromas, known as vestibular schwannoma. We performed target sequencing using Nest Generation Sequencer (NGS) . Four patients out of 10 patients (40%) showed NF2 gene mutations.

  Competitive research funding


• Novel biomaker for head and neck cancer in exosome

  Ken-ichi Nibu, Takeshi Fujita, Natsumi Uehara

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Kobe University, 01 Apr. 2015 - 31 Mar. 2017

  Technical procedures of exosome isolation and microRNA extraction from head and neck cancer cell lines were established. Based on these techniques, protocol of clinical research to identify novel biomarker for head and neck cancer was prepared and approved by Kobe University ethical committee. In this research, tissues of tumor and bloods from draining vein of tumor as well as tissues of contralateral normal organ and bloods from draining vein of contralateral normal organ are harvested. Exosomes are extracted and microRNAs are extracted from these materials. Results will be analyzed to identify novel biomarkers for head and neck cancer. Our results will contribute to early diagnosis of head and neck cancer and lead to development of gene therapy using replication-selective adenoviral vector with specific promotor for head and neck cancer.


• Clarification of pathological condition and therapeutic development of Xeroderma pigmentosum with model mice experiments

  KOJIMA Yasutaka, YAMASHITA Daisuke, FUJITA Takeshi, SHINOMIYA Hitomi, NISHIGORI Chikako

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Kobe University, 01 Apr. 2014 - 31 Mar. 2016

  For a treatment strategy for progressive sensorineural hearing loss in Xeroderma pigmentosum (XP), we evaluated a vulnerability of inner ears in XP complementation group A (XPA) model mice morphologically and physiologically. In auditory brainstem response, a hearing threshold of XPA model mice elevated higher than that of control group. In microscopic observation of sacrificed cochlear section, ganglion spiral cochlear cells decreased in XPA model mice. This is a first report on fragile inner ear in XPA model mice, therefore it becomes a cornerstone of inquisition of pathological condition and treatments of progressive sensorineural hearing loss in XP in the future.


• Metabolomic profiling in inner ear fluid by gas chromatograpy-mass

  HASEGAWA SHINGO, YAMASHITA Daisuke, FUJITA Takeshi, YOSHIDA Masaru

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2012 - 31 Mar. 2015

  The composition and homeostasis of the inner ear fluids are important for hearing function. This study is for the first time to perform metabolome analysis of the inner ear fluid in guinea pigs cochlea using gas-chromatography/mass-spectrometry (GC/MS). Seventy-seven kinds of metabolites were detected in the inner ear fluid. Six metabolites; ascorbic acid, fructose, galactosamine, inositol, pyruvate + oxalacetic acid and meso-erythritol were significantly more abundant and nine metabolites; phosphate, valine, glycine, glycerol, ornithine, glucose, citric acid + isocitric acid, mannose and trans-4-Hydroxy-L-proline were less frequent in the inner ear fluid than in plasma. The level of ten metabolites; 3-Hydroxy-Butyrate, glycerol, fumaric acid, galactosamine, pyruvate + oxalacetic acid, phosphate, meso-erythritol, citric acid + isocitric acid, mannosea and inositol in the inner ear fluid significantly changed after loud noise exposure.


• Regulation of drug permeability of the blood-inner ear barrier by RNA interference method

  TANIMOTO Hitoshi, OTSUKI Naoki, YAMASHITA Daisuke, KATSUNUMA Sayaka, FUJITA Takeshi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2012 - 31 Mar. 2015

  By RNA interference method, it is possible to suppress the transcription of protein structure of the blood-inner ear barrier, and to adjust the blood-inner ear barrier barrier mechanism. For the mouse to adjust the blood-inner ear barrier barrier mechanism, intravenous drug to the systemic administration, we want to prove that the drug has reached the inner ear. It is acoustic trauma modeling gives a huge acoustic trauma, and is administered inhibit RNA interference agent through the intravenous of which is the main protein claudin-5 transcription of the blood-inner ear barrier. Then, intravenously to be administered through the brain-derived neurotrophic factor (BDNF) as a neuroprotective agent for the purpose of inner ear disorder cell regeneration. And a control mouse morphological, we went electrophysiological comparison.

  Competitive research funding


• Mechanism of cell death and development of a new therapy against noise-induced hearing loss

  YAMASHITA Daisuke, KANZAKI Sho, FUJITA Takeshi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 2011 - 2013

  We first manufactured the animal models that became hearing loss induced by intense noise. In the hearing loss animal model, we elucidated the mechanism which led to the cell death (apoptosis) of inner hair cells. Finally, based on these results, we examined the method that hearing loss was treated by various kinds of approaches, and the results that might cure hearing loss in the both sides where were in hearing function / inner ear morphology were obtained.


• Investigating the mechanism of diabetes associated hearing impairment by aging.

  FUJITA Takeshi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Kobe University, 2011 - 2012

  We aimed to investigate the pathophysiology of diabetes- associated hearing impairment in type1 diabetes using mice with diabetes. Chronologic changes in the ABR threshold shift were not significantly different between the diabetic and control groups. However, vessel walls in the modiolus of the cochleae were significantly thicker inthe diabetic group than the control group. Additionally, recovery from noise-induced injury was significantly impaired in diabetic mice. Our data suggest that diabetic cochleae are more susceptible than controls to loud noise exposure.