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SANADA Shoji
University Hospital / Center for Clinical Research
Professor

Researcher basic information

■ Research Areas
  • Life sciences / Healthcare management, medical sociology
  • Life sciences / Cardiology
■ Committee History
  • Mar. 2026 - Present, 厚生労働省, 大臣官房厚生科学課 参与（医務技術行政担当）
  • Jul. 2025 - Present, 日本医療研究開発機構, 医療研究開発革新基盤創成事業（CiCLE）プログラムスーパーバイザー
  • Apr. 2024 - Present, ARO協議会, 認定制度委員会 委員
  • Jan. 2024 - Present, 日本臨床薬理学会, 認定臨床研究専門職選考委員会 委員
  • Feb. 2023 - Present, 日本臨床試験学会, 編集委員会 委員
  • Feb. 2023 - Present, 日本臨床試験学会, 理事
  • Jan. 2023 - Present, 日本臨床薬理学会, 認定臨床研究専門職制度委員会 委員
  • Sep. 2022 - Present, ARO協議会, 理事
  • Apr. 2021 - Present, 日本臨床試験学会, 将来構想委員会 委員
  • Apr. 2021 - Present, 日本医療研究開発機構, 課題評価委員
  • Dec. 2019 - Present, 厚生労働省, 医療上の必要性の高い未承認薬・適応外薬検討会議 循環器WG 委員
  • Jun. 2019 - Present, 日本臨床薬理学会, 学術委員会 委員
  • Oct. 2018 - Present, 日本学術振興会, 科学研究費委員会 専門委員
  • Jan. 2018 - Present, 日本臨床薬理学会, 専門医試験委員会 委員
  • Dec. 2017 - Present, 日本臨床薬理学会, 専門医制度委員会 委員
  • Oct. 2016 - Present, 厚生労働省, 先進医療技術審査部会 構成員

Research activity information

■ Paper
  • Hidenori Hashimoto, Miwa Sekine, Yuji Nishizaki, David Aune, Atsushi Mizuno, Yasuhiro Homma, Yasuhiko Kiyama, Shoji Sanada, Shigeki Aoki
    Feb. 2025, CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 18(2) (2), English
    Scientific journal

  • Atsushi Mizuno, Daisuke Yoneoka, Takuya Kishi, Kenya Kusunose, Chisa Matsumoto, Yuki Sahashi, Mari Ishida, Shoji Sanada, Memori Fukuda, Tadafumi Sugimoto, Miki Hirano, Masataka Sata, Toshihisa Anzai, Koichi Node
    BACKGROUND: The influence of a change to a default X summary posting strategy on article viewership has not been investigated. METHODS AND RESULTS: We conducted a retrospective analysis of X-posting rates and journal viewership data for both the Circulation Journal and Circulation Reports from April 2022 to September 2023. Following protocol modifications in March 2023, there was a notable increase in the X-posting rate from 12.4% to 61.7%, along with an uptick in median access counts to article pages within 30 days, from 175 to 231.5. CONCLUSIONS: Trend analysis of journal viewership after a default X-posting strategy revealed an increase in viewer access.
    Japanese Circulation Society, Aug. 2024, Circulation Reports, 6(9) (9), 389 - 394, English, Domestic magazine
    Scientific journal

  • Takahiro Suzuki, Atsushi Mizuno, Takuya Kishi, Jeffrey Rewley, Chisa Matsumoto, Yuki Sahashi, Mari Ishida, Shoji Sanada, Memori Fukuda, Tadafumi Sugimoto, Miki Hirano, Koichi Node
    Background: Previous research has investigated the effectiveness of the "Tweet the Meeting" campaign, but the relationship between tweet content and the number of retweets has not been fully evaluated. Methods and Results: We analyzed the number of tweets and retweets during the Japanese Circulation Society's 2022 annual meeting. The ambassador group had significantly more session- and symposium-related tweets than the non-ambassador group (P<0.001), associated with the nubmer of retweets. Symposium-related tweets with figures generated more retweets than those without figures (mean [±SD] 3.47±3.31 vs. 2.48±1.94 retweets per tweet, respectively; P=0.001). Conclusions: The study revealed that official meeting-designated Twitter ambassadors disseminate more educational content than non-ambassadors, and generated more retweets.
    Japanese Circulation Society, Jun. 2023, Circulation Reports, 5(7) (7), 306 - 310, English, Domestic magazine
    Scientific journal

  • Miwa Sekine, Yasuhiko Kiyama, Rieko Ueda, David Aune, Shoji Sanada, Yuji Nishizaki
    OBJECTIVES: With increasing multinational research in general medicine, the lack of a standardized policy regarding the order of author bylines can create conflict and misunderstanding due to different practices worldwide. METHODS: We examined publicly available data from websites such as Journal Citation Reports and Web of Science, focusing on original articles published in the "Medicine, General, & Internal" category in 2020. Of 169 journals in the "Medicine, General, & Internal" category, we selected the ten countries with the highest number of publications and then examined the position of the corresponding author in the author byline as an indicator of the author in charge since corresponding authors are considered to have contributed the most. RESULTS: The top ten countries with the highest publications are the USA, China, Germany, England, Japan, France, Italy, Canada, India, and Australia. The results demonstrated that the percentage of the second author being the corresponding author was the highest in Japan compared to other countries. This percentage was 25 times higher in Japan than in the USA. CONCLUSIONS: Understanding international differences regarding author order would facilitate smoother collaboration.
    2023, Juntendo Iji zasshi = Juntendo medical journal, 69(5) (5), 405 - 408, English, Domestic magazine
    Scientific journal

  • Miwa Sekine, Koshi Kataoka, Yuji Nishizaki, Kotone Matsuyama, Toshiaki Otsuka, Kensuke Sato, Mayumi Idei, Shoji Sanada
    Principal investigators (PIs) play a key role in clinical research, and must thus understand the role of clinical research support staff to conduct successful and appropriate clinical research. This study evaluates clinical research capabilities by examining the clinical research knowledge of PIs and clinical research support staff. The participants of this cross-sectional study were academic researchers and clinical research support staff from Japanese universities and research institutions. The participants comprised of 54 respondents, among whom 36 were PIs (physicians) and 18 were clinical research support staff. A self-administered electronic survey was created and evaluated by experts, with 50 knowledge items. Mann-Whitney U tests were used to determine the significance of the differences in knowledge between clinical research support staff and PIs. We compared the correct answer rate of clinical research support staff and PIs for each knowledge category and observed that the clinical research support staff scored significantly higher than the PIs in all aspects of clinical research knowledge sections, including total score. Our findings showed that PIs did not have the same amount of clinical research knowledge as the clinical research support staff. Clinical research knowledge is essential for investigators, especially PIs, to protect patients and promote medical breakthroughs. Thus, more accessible clinical research education and mandatory knowledge testing will allow PIs to lead successful clinical research and further the level of medical research in Japan.
    Nov. 2022, Clinical and translational science, 16(3) (3), 459 - 466, English, International magazine
    Scientific journal

  • Atsushi Mizuno, Kenya Kusunose, Takuya Kishi, Jeffrey Rewley, Chisa Matsumoto, Yuki Sahashi, Mari Ishida, Shoji Sanada, Memori Fukuda, Tadafumi Sugimoto, Miki Hirano, Daisuke Yoneoka, Masataka Sata, Toshihisa Anzai, Koichi Node
    BACKGROUND: The impact of promotional tweets from the official journal account (forCirculation JournalandCirculation Reports) on article viewership has not been thoroughly evaluated.Methods and Results:We retrospectively collected journal viewership data forCirculation JournalandCirculation Reportsfrom March 2021 to August 2021. We compared viewership between articles with (n=15) and without (n=250) tweets. After 1 : 4 propensity score matching (15 tweeted articles and 60 non-tweeted matched controls), journal viewership metrics within 7 days of the tweeting date (and the hypothetical tweeting date), was larger in tweeted articles than non-tweeted articles (median [interquartile range] Abstract page views 89 [60-104] vs. 18 [8-41]). CONCLUSIONS: This pilot study suggests a positive relationship between journal-posted promotional tweets and article viewership.
    Japanese Circulation Society, Mar. 2022, Circulation Journal, 86(4) (4), 715 - 720, English, Domestic magazine
    Scientific journal

  • Fumito Morisawa, Yuji Nishizaki, Patrick Devos, Naotake Yanagisawa, Kotone Matsuyama, Yasuhiro Homma, Rieko Ueda, Miwa Sekine, Hiroyuki Daida, Tohru Minamino, Shoji Sanada
    INTRODUCTION: Studies have not sufficiently clarified the differences in citation impact between funded and non-funded clinical research papers. Hence, this study seeks to evaluate the relation between research funding status and clinical research papers' citation impact in different research fields using multiple evaluation indices. METHODS: In this cross-sectional bibliometric study, clinical research papers published by core clinical research hospitals in Japan were compared retrospectively in terms of times cited (TC), category normalized citation impact (CNCI), citation percentile (CP), journal impact factor (JIF), the Software to Identify, Manage, and Analyze Scientific Publications (SIGAPS) category, and whether they were the funded clinical research. The association between research funding status or the SIGAPS category and CNCI ≥ 2 was analyzed using logistic regression analysis. RESULTS: 11 core clinical research hospitals published 553 clinical research papers, of which 120 were non-funded and 433 were funded (public institution-funded and industry-funded). The study found that funded clinical research papers (public institution-funded and industry-funded) had significantly higher TC, CNCI, CP, and JIF than non-funded ones [TC: 8 (3-17) vs. 14 (8-31), p < 0.001; CNCI: 0.53 (0.19-0.97) vs. 0.87 (0.45-1.85), p < 0.001; CP: 51.9 (24.48-70.42) vs. 66.7 (40.53-88.01), p < 0.001; JIF: 2.59 (1.90-3.84) vs. 2.93 (2.09-4.20) p = 0.008], while the proportion of A or B rank clinical research papers of the SIGAPS category was not significantly different between the two groups (30.0 vs. 34.9%, p = 0.318). In the logistic regression analysis, having a CNCI ≥ 2 was significantly associated with research funding (public institution-funded and industry-funded) and publication in A or B rank journals of the SIGAPS category [research funding: Estimate 2.169, 95% confidence interval (CI) 1.153-4.083, p = 0.016; SIGAPS category A/B: Estimate 6.126, 95% CI 3.889-9.651, p < 0.001]. CONCLUSION: Analysis via multiple indicators including CNCI and the SIGAPS category, which allows for a comparison of the papers' citation impact in different research fields, found a positive relation between research funding status and the citation impact of clinical research papers.
    2022, Frontiers in medicine, 9, 978174 - 978174, English, International magazine
    [Refereed]
    Scientific journal

  • OTANI Naoyuki, MATSUNO Yasuko, SANADA Shoji, SHIOZAKI Masayuki, HISAMOTO Kana, MIZUKI Fumitaka, ARAKI Hiroyuki, TAJIRI Ryo, INADA Mieko, HIDA Noriko, ARITA Etsuko

    The quality of clinical research design can be improved in a way by involving support-professional in charge of Quality Control (QC) and Quality Assurance (QA) since the initial stage of the research. The second way is to introduce the concept of Quality by Design (QbD) to propose research designs in view of the future and cooperate with researchers. Thus, in addition to strengthen the support function for the construction of research plan designs, each support-professional must collaborate with researchers since the early planning stage to formulate research plans, thereby ensuring the quality of the research process and deliverables. We participated in a multidisciplinary collaborative workshop. The purpose of this workshop was “creation of an efficient multi-professional collaborative educational program and development of an effective multi-professional collaborative clinical study workshop utilizing the linkage of occupation-specific and cross-cutting core competencies (Principal Investigator: Shoji Sanada)” in the “investigation and business summary of the multidisciplinary workshop” as the 2nd year of Reiwa Central Institutional Review Board Promotion project in Japan Agency for Medical Research and Development (AMED). We had brushed up the protocol synopsis in this multi-professional collaborative workshop, further revised it, and made a draft protocol with the workshop members. We expect that this study will help to build a multidisciplinary educational program in this project.

    The Japanese Society of Clinical Pharmacology and Therapeutics, Dec. 2021, Japanese Journal of Clinical Pharmacology and Therapeutics, 52(6) (6), 165 - 173, Japanese
    [Refereed]

  • Rieko Ueda, Yuji Nishizaki, Yasuhiro Homma, Patrick Devos, Shoji Sanada
    Nov. 2021, Journal of general and family medicine, 22(6) (6), 361 - 362, English, Domestic magazine
    Scientific journal

  • Atsushi Mizuno, Jeffrey Rewley, Takuya Kishi, Chisa Matsumoto, Yuki Sahashi, Mari Ishida, Shoji Sanada, Memori Fukuda, Tadafumi Sugimoto, Miki Hirano, Koichi Node
    Background: The relationship between Twitter ambassadors and retweets has not been fully evaluated for "tweet the meeting" activity. Methods and Results: We collected data on the number of tweets and retweets during the Japanese Circulation Society's (JCS) annual meetings in 2019, 2020, and 2021. After adjustment, JCS Twitter Ambassadors, selected by the JCS to increase the meeting's visibility, increased the total number of retweets by 9%. Conclusions: This is the first report on the numerical relationship between JCS Twitter Ambassadors and the total number of retweets during an annual congress. Original tweets by JCS Twitter Ambassadors increased the number of retweets, but retweets by influencers were more effective at stimulating social media engagement.
    Jul. 2021, Circulation reports, 3(7) (7), 414 - 418, English, Domestic magazine
    Scientific journal

  • Keiko Ueda, Naoto Uemura, Kotone Matsuyama, Yuji Nishizaki, Nanae Tanemura, Kento Asano, Yuki Otsuka, Naotake Yanagisawa, Toshiaki Otsuka, Shinji Yasuno, Rieko Ueda, Yumiko Seo, Hironori Nakagami, Shoji Sanada
    Mar. 2021, Clinical and translational science, 14(2) (2), 745 - 755, English, International magazine
    [Refereed]
    Scientific journal

  • Atsushi Mizuno, Chisa Matsumoto, Daisuke Yoneoka, Takuya Kishi, Mari Ishida, Shoji Sanada, Memori Fukuda, Yoshihiko Saito, Keiko Yamauchi-Takihara, Hiroyuki Tsutsui, Keiichi Fukuda, Issei Komuro, Koichi Node
    Background: From the early phase of the Coronavirus disease-2019 (COVID-19) pandemic, cardiologists have paid attention not only to COVID-19-associated cardiovascular sequelae, but also to treatment strategies for rescheduling non-urgent procedures. The chief objective of this study was to explore confirmed COVID-19 cardiology case experiences and departmental policies, and their regional heterogeneity in Japan. Methods and Results: We performed a retrospective analysis of a nationwide survey performed by the Japanese Circulation Society on April 13, 2020. The questionnaire included cardiology department experience with confirmed COVID-19 cases and restriction policies, and was sent to 1,360 certified cardiology training hospitals. Descriptive analysis and spatial autocorrelation analysis of each response were performed to reveal the heterogeneity of departmental policies. The response rate was 56.8% (773 replies). Only 16% of all responding hospitals experienced a COVID-19 cardiology case. High-risk procedures were restricted in more than one-fifth of hospitals, including transesophageal echocardiography (34.9%) and scheduled catheterization (39.5%). The presence of a cardiologist in the COVID-19 team, the number of board-certified cardiologists, any medical resource shortage and a state of emergency were positively correlated with any type of restriction. Conclusions: We found both low clinical case experiences with COVID-19 and restrictions of cardiovascular procedures during the first COVID-19 wave in Japan. Restrictions arising as a result of COVID-19 were affected by hospital- and country-level variables, such as a state of emergency.
    Feb. 2021, Circulation reports, 3(3) (3), 137 - 141, English, Domestic magazine
    Scientific journal

  • Atsushi Mizuno, Chisa Matsumoto, Takuya Kishi, Mari Ishida, Shoji Sanada, Memori Fukuda, Issei Komuro, Kenichi Hirata, Koichi Node
    Background: Cardiovascular department restriction policies on procedures resulting from the COVID-19 pandemic have not been fully evaluated. Methods and Results: We performed a retrospective analysis of a nationwide survey performed by the Japanese Circulation Society in August 2020. The total response rate was 48.9% (651/1,331). The rate of restriction of cardiovascular procedures peaked in April. Exacerbations of heart failure due to hospital restrictions were noted in 43.8% of departments. Conclusions: Many departments restricted their cardiological procedures, and this rate changed according to the pandemic situation. The exacerbation of cardiovascular disease resulting from pandemic restrictions should not be ignored.
    Jan. 2021, Circulation reports, 3(2) (2), 100 - 104, English, Domestic magazine
    Scientific journal

  • Rieko Ueda, Yuji Nishizaki, Shuko Nojiri, Hiroshi Iwata, Katsumi Miyauchi, Kotone Matsuyama, Shoji Sanada, Tohru Minamino, Hiroyuki Daida
    Under-recruitment in clinical trials is an issue worldwide. If the number of patients enrolled is lower than expected, based on the required sample size, then the reliability of the study results and their validation tend to be impaired. The current study therefore evaluated factors associated with accelerating patient enrollment using data from an ongoing multicenter prospective cohort study. The researchers encouraged research institutions to accelerate patient enrollment via e-mail, newsletters, telephone calls, and site visits. We analyzed the relationship between several potential factors associated with acceleration of patient enrollment including site visits and patient enrollment in a real clinical study. Data were collected from 106 research institutions that participated in a multicenter prospective cohort study. Results showed that the following parameters differed in terms of patient enrollment and non-enrollment: urban area (47.2 vs. 67.6%, p = 0.04), clinical research coordinator (CRC) participation in data input to electronic data capture (EDC) (41.7 vs. 11.8%, p < 0.01), and site visit (38.9 vs. 11.8%, p < 0.01). A multivariate analysis revealed that patient enrollment was significantly associated with urban area (odds ratio [OR] 0.33, 95% confidence interval [CI] 0.12-0.86, p = 0.02), CRC participation in data input to EDC (OR 5.02; 95% CI 1.49-16.8; p < 0.01), and site visit (OR 4.54, 95% CI 1.31-15.7, p = 0.01). In conclusion, site visits and CRC participation in data input to EDC had a significant effect on patient enrollment promotion. Moreover, hospitals in rural areas were more effective in promoting patient enrollment than those in urban areas.
    2021, Frontiers in pharmacology, 12, 753067 - 753067, English, International magazine
    [Refereed]
    Scientific journal

  • Takuya Kishi, Atsushi Mizuno, Mari Ishida, Chisa Matsumoto, Memori Fukuda, Shoji Sanada, Naoya Itoh, Hideaki Oka, Koichi Node, Issei Komuro
    BACKGROUND: The Japanese Circulation Society proposes recommendations for all healthcare professionals involved in cardiovascular medicine to protect them from infection and ensure that seriously ill patients requiring urgent care receive proper treatment.Methods and Results:Patients are divided into "Positive or suspected coronavirus disease 2019 (COVID-19)" and "All others". Furthermore, tests and treatments are divided into emergency or standby. For each category, we propose recommendations. CONCLUSIONS: To maintain the cardiovascular care system, The Japanese Circulation Society recommends completely preventing nosocomial COVID-19 infections, ensuring adequate PPE necessary for healthcare personnel, and learning and implementing standard precautions.
    Oct. 2020, Circulation journal : official journal of the Japanese Circulation Society, 84(11) (11), 2023 - 2026, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Atsushi Mizuno, Takuya Kishi, Chisa Matsumoto, Mari Ishida, Shoji Sanada, Memori Fukuda, Yuki Sahashi, Tadafumi Sugimoto, Miki Hirano, Yusuke Yoshikawa, Erika Yamamoto, Takeshi Kimura, Koichi Node
    Background: Twitter has become increasingly popular at annual medical congresses as a platform to communicate to attendees. The aim of this study is to reveal the twitter usage in the annual congress of the Japanese Cirsulation Society. Methods and Results: We compared the total number of tweets during the Japanese Circulation Society's annual meetings in 2019 and 2020. The total number of tweets increased from 7,587 in 2019 to 23,867 in 2020. Most tweets were retweets (>70%), and approximately half of Twitter users tweeted only once. Conclusions: Twitter usage during the Japanese Circulation Society's annual meeting increased from 2019 to 2020, and a large number of tweets were from Twitter ambassadors of the Japanese Circulation Society. However, further evaluation is needed, with future studies investigating the usefulness of this platform.
    Sep. 2020, Circulation reports, 2(11) (11), 691 - 694, English, Domestic magazine
    Scientific journal

  • Yuji Nishizaki, Yasuhiro Homma, Rieko Ueda, Patrick Devos, Shoji Sanada
    Sep. 2020, Journal of general and family medicine, 21(5) (5), 208 - 209, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Tadafumi Sugimoto, Atsushi Mizuno, Takuya Kishi, Naoya Ito, Chisa Matsumoto, Memori Fukuda, Nobuyuki Kagiyama, Tatsuhiro Shibata, Takashi Ohmori, Shogo Oishi, Jun Fuse, Keisuke Kida, Fujimi Kawai, Mari Ishida, Shoji Sanada, Issei Komuro, Koichi Node
    BACKGROUND: Despite the rapidly increasing attention being given to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, more commonly known as coronavirus disease 2019 (COVID-19), the relationship between cardiovascular disease and COVID-19 has not been fully described. METHODS AND RESULTS: A systematic review was undertaken to summarize the important aspects of COVID-19 for cardiologists. Protection both for patients and healthcare providers, indication for treatments, collaboration with other departments and hospitals, and regular update of information are essentials to front COVID-19 patients. CONCLUSIONS: Because the chief manifestations of COVID-19 infection are respiratory and acute respiratory distress syndrome, cardiologists do not see infected patients directly. Cardiologists need to be better prepared regarding standard disinfection procedures, and be aware of the indications for extracorporeal membrane oxygenation and its use in the critical care setting.
    May 2020, Circulation journal : official journal of the Japanese Circulation Society, 84(6) (6), 1039 - 1043, English, Domestic magazine
    Scientific journal

  • Takuya Kishi, Teruyuki Hirano, Atsushi Mizuno, Yoichiro Hashimoto, Chisa Matsumoto, Memori Fukuda, Shoji Sanada, Mari Ishida, Koichi Node, Susumu Miyamoto, Issei Komuro
    May 2020, Circulation reports, 2(6) (6), 343 - 344, English, Domestic magazine
    Scientific journal

  • Atsushi Mizuno, Takuya Kishi, Chisa Matsumoto, Fujimi Kawai, Mari Ishida, Shoji Sanada, Seiji Hokimoto, Yoshihiko Saito, Keiko Yamauchi-Takihara, Issei Komuro, Koichi Node
    Background: Twitter has become increasingly popular at annual medical congresses as a platform to communicate to attendees. In contrast, Twitter is not as frequently used in Japan as compared with other countries. Herein, we reviewed the literature and discuss the potential role and risks of "tweet the meeting" in Japan. Methods and Results: We performed a literature review to consider the recent trend of tweeting the meeting, including benefits and how to tweet, as well as potential risks. Upon officially deciding to tweet the meeting, a number of societies and professional organizations developed strategies to enhance the attendees' experience using multiple modalities and guides. Although there are several risks, we provide a concise guide to tweeting the meeting for the Japanese audience, which could be useful for understanding what should be done before and during a conference. Conclusions: The use of Twitter at medical congresses has many possibilities, and there are numerous potentials in many areas. We should discuss this in the light of the benefits for congress attendees in Japan.
    Sep. 2019, Circulation reports, 1(10) (10), 401 - 404, English, Domestic magazine
    Scientific journal

  • 超高齢化・医療費膨張時代における循環器医療提供体制と医療政策のあり方 心血管系医療制度を改善するための急性心血管疾患の指標と転帰予測モデルの確立(Establishment of Indicators and Outcome Prediction Model of Acute Cardiovascular Diseases to Improve Cardiovascular Medical Service System)
    坂田 泰史, 磯部 光章, 安田 聡, 宮本 恵宏, 西村 邦宏, 添田 恒有, 今村 知明, 平山 篤志, 辻田 賢一, 中尾 浩一, 森野 禎浩, 上田 裕一, 高山 守正, 島村 和男, 土肥 智晴, 岡田 佳築, 真田 昌爾, 彦惣 俊吾, 小室 一成
    (一社)日本循環器学会, Mar. 2019, 日本循環器学会学術集会抄録集, 83回, SY24 - 1, English
    [Refereed]

  • 大阪大学医学部附属病院における臨床研究法への対応
    浅野 健人, 岩崎 幸司, 小林 万紀子, 真田 昌爾, 山本 洋一
    (株)臨床評価刊行会, Feb. 2019, 臨床評価, 46(3-4) (3-4), 489 - 495, Japanese

  • Rieko Ueda, Yuji Nishizaki, Yasuhiro Homma, Shoji Sanada, Toshiaki Otsuka, Shinji Yasuno, Kotone Matsuyama, Naotake Yanagisawa, Masashi Nagao, Kazutoshi Fujibayashi, Shuko Nojiri, Yumiko Seo, Natsumi Yamada, Patrick Devos, Hiroyuki Daida
    2019, Frontiers in Pharmacology, 10
    [Refereed]
    Scientific journal

  • Tsuchida S, Matsuzaki T, Yamato M, Okuda K, Fu HY, Araki R, Sanada S, Asanuma H, Asano Y, Asakura M, Hao H, Takashima S, Kitakaze M, Sakata Y, Mekada E, Minamino T
    Nov. 2018, International heart journal, 59(6) (6), 1425 - 1431
    [Refereed]

  • Araki R, Matsuzaki T, Nakamura A, Nakatani D, Sanada S, Fu HY, Okuda K, Yamato M, Tsuchida S, Sakata Y, Minamino T
    Jul. 2018, Pharmaceutical development and technology, 23(6) (6), 602 - 607
    [Refereed]

  • Hiroshi Asanuma, Shoji Sanada, Toru Yoshitomi, Hideyuki Sasaki, Hiroyuki Takahama, Madoka Ihara, Hiroko Takahama, Yoshiro Shinozaki, Hidezo Mori, Masanori Asakura, Atsushi Nakano, Masaru Sugimachi, Yoshihiro Asano, Tetsuo Minamino, Seiji Takashima, Yukio Nagasaki, Masafumi Kitakaze
    Dec. 2017, CARDIOVASCULAR DRUGS AND THERAPY, 31(5-6) (5-6), 501 - 510, English
    [Refereed]
    Scientific journal

  • Masaki Yamato, Takashi Matsuzaki, Ryo Araki, Shota Tsuchida, Keiji Okuda, Hai Ying Fu, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Hiroomi Torii, Kentaro Noi, Hirotsugu Ogi, Ryo Iwamoto, Eisuke Mekada, Seiji Takashima, Masafumi Kitakaze, Yasushi Sakata, Tetsuo Minamino
    Sep. 2017, INTERNATIONAL JOURNAL OF GERONTOLOGY, 11(3) (3), 191 - 196, English
    Scientific journal

  • Punniyakoti T. Veeraveedu, Shoji Sanada, Keiji Okuda, Hai Ying Fu, Takashr Matsuzaki, Ryo Araki, Masaki Yamato, Koubun Yasuda, Yasushi Sakata, Tomohiro Yoshimoto, Tetsuo Minamino
    Aug. 2017, BIOCHEMICAL PHARMACOLOGY, 138, 73 - 80, English
    [Refereed]
    Scientific journal

  • Keiji Okuda, Hai Ying Fu, Takashi Matsuzaki, Ryo Araki, Shota Tsuchida, Punniyakoti V. Thanikachalam, Tatsuya Fukuta, Tomohiro Asai, Masaki Yamato, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Haruo Hanawa, Hiroyuki Hao, Naoto Oku, Seiji Takashima, Masafumi Kitakaze, Yasushi Sakata, Tetsuo Minamino
    Aug. 2016, PLOS ONE, 11(8) (8), e0160944, English
    [Refereed]
    Scientific journal

  • Ito S, Asakura M, Liao Y, Min KD, Takahashi A, Shindo K, Yamazaki S, Tsukamoto O, Asanuma H, Mogi M, Horiuchi M, Asano Y, Sanada S, Minamino T, Takashima S, Mochizuki N, Kitakaze M
    Jul. 2016, Journal of the American Heart Association, 5(7) (7), English
    [Refereed]
    Scientific journal

  • Hai Ying Fu, Shoji Sanada, Takashi Matsuzaki, Yulin Liao, Keiji Okuda, Masaki Yamato, Shota Tsuchida, Ryo Araki, Yoshihiro Asano, Hiroshi Asanuma, Masanori Asakura, Brent A. French, Yasushi Sakata, Masafumi Kitakaze, Tetsuo Minamino
    Mar. 2016, CIRCULATION RESEARCH, 118(5) (5), 798 - 809, English
    [Refereed]
    Scientific journal

  • Asanuma H, Sanada S, Asakura M, Asano Y, Kim J, Shinozaki Y, Mori H, Minamino T, Takashima S, Kitakaze M
    Aug. 2014, Hypertension research : official journal of the Japanese Society of Hypertension, 37(8) (8), 716 - 23, English
    [Refereed]
    Scientific journal

  • Takahashi A, Asakura M, Ito S, Min KD, Shindo K, Yan Y, Liao Y, Yamazaki S, Sanada S, Asano Y, Ishibashi-Ueda H, Takashima S, Minamino T, Asanuma H, Mochizuki N, Kitakaze M
    May 2013, American journal of physiology. Heart and circulatory physiology, 304(10) (10), H1361 - 9
    [Refereed]

  • Takahama H, Shigematsu H, Asai T, Matsuzaki T, Sanada S, Fu HY, Okuda K, Yamato M, Asanuma H, Asano Y, Asakura M, Oku N, Komuro I, Kitakaze M, Minamino T
    Apr. 2013, Cardiovascular drugs and therapy, 27(2) (2), 125 - 132
    [Refereed]

  • イヌ心臓において新たに合成したラジカル含有ナノ粒子は一酸化窒素を介して虚血再灌流傷害後の心保護を増大させる(Novel Synthesized Radical-containing Nanoparticles Augment Cardioprotection after Ischemia-reperfusion Injury via Nitric Oxide in Canine Hearts)
    Yoshida Akemi, Asanuma Hiroshi, Sanada Shoji, Sasaki Hideyuki, Takahama Hiroyuki, Asakura Masanori, Minamino Tetsuo, Takashima Seiji, Mochizuki Naoki, Kitakaze Masafumi
    (一社)日本循環器学会, Mar. 2013, Circulation Journal, 77(Suppl.I) (Suppl.I), 141 - 141, English

  • Shoji Sanada, Makoto Nishida, Kouki Ishii, Toshiki Moriyama, Issei Komuro, Keiko Yamauchi-Takihara
    Dec. 2012, CIRCULATION JOURNAL, 76(12) (12), 2884 - 2891, English
    [Refereed]
    Scientific journal

  • Yoshida A, Asanuma H, Sasaki H, Sanada S, Yamazaki S, Asano Y, Shinozaki Y, Mori H, Shimouchi A, Sano M, Asakura M, Minamino T, Takashima S, Sugimachi M, Mochizuki N, Kitakaze M
    Jun. 2012, Cardiovascular drugs and therapy, 26(3) (3), 217 - 226
    [Refereed]

  • 地域ベースの集団における左室拡張機能障害と左室肥大の有病率、およびそれらの関係(Prevalence and Relation of Left Ventricular Diastolic Dysfunction and Hypertrophy in a Community-based Population)
    Hasegawa Takuya, Asakura Masanori, Kanzaki Hideaki, Kim Jiyoong, Asanuma Hiroshi, Sanada Shoji, Funada Akira, Amaki Makoto, Takahama Hiroyuki, Kitakaze Masafumi
    (一社)日本循環器学会, Mar. 2012, Circulation Journal, 76(Suppl.I) (Suppl.I), 2679 - 2679, English

  • WEB調査票システムの構築と学生健診への導入
    明石 美智子, 白根 峰子, 大濱 透, 市川 昊平, 江原 康生, 西田 誠, 真田 昌爾, 守山 敏樹, 杉田 義郎, 瀧原 圭子
    (公社)全国大学保健管理協会, 2012, CAMPUS HEALTH, 49(4) (4), 77 - 77, Japanese

  • Shoji Sanada, Hiroshi Asanuma, Tetsuo Minamino, Osamu Tsukamoto, Kenichiro Okada, Masafumi Kitakaze, Issei Komuro
    Bentham Science Publishers B.V., 2012, Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, 12(2) (2), 130 - 136, English
    [Refereed]
    Scientific journal

  • Sohma R, Inoue T, Abe S, Taguchi I, Kikuchi M, Toyoda S, Arikawa T, Hikichi Y, Sanada S, Asanuma H, Kitakaze M, Node K
    Jan. 2012, Journal of cardiology, 59(1) (1), 91 - 96
    [Refereed]

  • Shoji Sanada, Issei Komuro
    2011, Circulation Journal, 75(3) (3), 540 - 541, English
    [Refereed]
    Scientific journal

  • Takahama H, Asanuma H, Sanada S, Fujita M, Sasaki H, Wakeno M, Kim J, Asakura M, Takashima S, Minamino T, Komamura K, Sugimachi M, Kitakaze M
    Nov. 2010, Basic research in cardiology, 105(6) (6), 787 - 794
    [Refereed]

  • Shuichiro Higo, Yoshihiro Asano, Hisakazu Kato, Satoru Yamazaki, Atsushi Nakano, Osamu Tsukamoto, Osamu Seguchi, Mitsutoshi Asai, Masanori Asakura, Hiroshi Asanuma, Shoji Sanada, Tetsuo Minamino, Issei Komuro, Masafumi Kitakaze, Seiji Takashima
    Oct. 2010, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(41) (41), 31337 - 31347, English
    [Refereed]
    Scientific journal

  • Ablation of C/EBP homologous protein attenuates ER-mediated apoptosis and cardiac dysfunction induced by pressure overload.
    Fu HY, Okada Ki, Liao Y, Tsukamoto O, Isomura T, Asai M, Sawada T, Okuda K, Asano Y, Sanada S, Asanuma H, Asakura M, Takashima S, Komuro I, Kitakaze M, Minamino T
    Aug. 2010, Circulation, English
    [Refereed]
    Scientific journal

  • Tamaki Sawada, Tetsuo Minamino, Hai Ying Fu, Mitsutoshi Asai, Keiji Okuda, Tadashi Isomura, Satoru Yamazaki, Yoshihiro Asano, Ken-ichiro Okada, Osamu Tsukamoto, Shoji Sanada, Hiroshi Asanuma, Masanori Asakura, Seiji Takashima, Masafumi Kitakaze, Issei Komuro
    Jun. 2010, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 48(6) (6), 1280 - 1289, English
    [Refereed]
    Scientific journal

  • Kyung-Duk Min, Masanori Asakura, Yulin Liao, Kenji Nakamaru, Hidetoshi Okazaki, Tomoko Takahashi, Kazunori Fujimoto, Shin Ito, Ayako Takahashi, Hiroshi Asanuma, Satoru Yamazaki, Tetsuo Minamino, Shoji Sanada, Osamu Seguchi, Atsushi Nakano, Yosuke Ando, Toshiaki Otsuka, Hidehiko Furukawa, Tadashi Isomura, Seiji Takashima, Naoki Mochizuki, Masafumi Kitakaze
    Feb. 2010, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 393(1) (1), 55 - 60, English
    [Refereed]
    Scientific journal

  • Kenjiro Seki, Shoji Sanada, Anastacia Y. Kudinova, Matthew L. Steinhauser, Vandna Handa, Joseph Gannon, Richard T. Lee
    Nov. 2009, CIRCULATION-HEART FAILURE, 2(6) (6), 684 - U211, English
    [Refereed]
    Scientific journal

  • Hideyuki Sasaki, Hiroshi Asanuma, Masashi Fujita, Hiroyuki Takahama, Masakatsu Wakeno, Shin Ito, Akiko Ogai, Masanori Asakura, Jiyoong Kim, Tetsuo Minamino, Seiji Takashima, Shoji Sanada, Masaru Sugimachi, Kazuo Komamura, Naoki Mochizuki, Masafumi Kitakaze
    May 2009, CIRCULATION, 119(19) (19), 2568 - U74, English
    [Refereed]
    Scientific journal

  • Shunsuke Tamaki, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shoji Sanada, Yasumasa Tsukamoto, Masaharu Masuda, Keiji Okuda, Yusuke Iwasaki, Taku Yasui, Masatsugu Hori, Masatake Fukunami
    Feb. 2009, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(5) (5), 426 - 435, English
    [Refereed]
    Scientific journal

  • Sodium bicarbonate improves long-term clinical outcomes compared with sodium chloride in patients with chronic kidney disease undergoing an emergent coronary procedure
    Masaharu Masuda, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shoji Sanada, Yoshio Furukawa, Yasumasa Tsukamoto, Keiji Okuda, Yuusuke Iwasaki, Taku Yasui, Masatake Fukunami
    Oct. 2008, CIRCULATION JOURNAL, 72(10) (10), 1610 - 1614, English
    [Refereed]
    Scientific journal

  • Fujita M, Asakura M, Sanada S, Funaya H, Tsukamoto O, Komamura K, Asanuma H, Taketani S, Isomura T, Nakamaru K, Furukawa H, Sawa Y, Hori M, Kitakaze M
    Jun. 2008, Journal of cardiac failure, 14(5) (5), 426 - 430
    [Refereed]

  • Sanada S, Asanuma H, Koretsune Y, Watanabe K, Nanto S, Awata N, Hoki N, Fukunami M, Kitakaze M, Hori M
    Oct. 2007, Hypertension research : official journal of the Japanese Society of Hypertension, 30(10) (10), 913 - 919
    [Refereed]

  • Shoji Sanada, Daihiko Hakuno, Luke J. Higgins, Eric R. Schreiter, Andrew N. J. McKenzie, Richard T. Lee
    Jun. 2007, JOURNAL OF CLINICAL INVESTIGATION, 117(6) (6), 1538 - 1549, English
    [Refereed]
    Scientific journal

  • Asanuma H, Nakai K, Sanada S, Minamino T, Takashima S, Ogita H, Fujita M, Hirata A, Wakeno M, Takahama H, Kim J, Asakura M, Sakuma I, Kitabatake A, Hori M, Komamura K, Kitakaze M
    2007, J Mol Cell Cardiol, 2007, 924 - 930, English
    [Refereed]
    Scientific journal

  • Tsukamoto O, Minamino T, Sanada S, Okada K, Hirata A, Fujita M, Shintani Y, Yulin L, Asano Y, Takashima S, Yamasaki S, Tomoike H, Hori M, Kitakaze M
    Apr. 2006, Cardiovasc Drugs Ther., English
    [Refereed]
    Scientific journal

  • Asanuma H, Minamino T, Ogai A, Kim J, Asakura M, Komamura K, Sanada S, Fujita M, Hirata A, Wakeno M, Tsukamoto O, Shinozaki Y, Myoishi M, Takashima S, Tomoike H, Kitakaze M
    Apr. 2006, J Mol Cell Cardiol., English
    [Refereed]
    Scientific journal

  • Fujita M, Minamino T, Asanuma H, Sanada S, Hirata A, Wakeno M, Myoishi M, Okuda H, Ogai A, Okada K, Tsukamoto O, Koyama H, Hori M, Kitakaze M
    Jul. 2005, Hypertension (Dallas, Tex. : 1979), 46(1) (1), 113 - 117
    [Refereed]

  • Y Li, T Minamino, O Tsukamoto, T Yujiri, Y Shintani, K Okada, Y Nagamachi, M Fujita, A Hirata, S Sanada, H Asanuma, S Takashima, M Hori, GL Johnson, M Kitakaze
    Apr. 2005, CIRCULATION, 111(13) (13), 1672 - 1678, English
    [Refereed]
    Scientific journal

  • Hirata A, Minamino T, Asanuma H, Sanada S, Fujita M, Tsukamoto O, Wakeno M, Myoishi M, Okada K, Koyama H, Komamura K, Takashima S, Shinozaki Y, Mori H, Tomoike H, Hori M, Kitakaze M
    Jan. 2005, Cardiovascular drugs and therapy, 19(1) (1), 33 - 40
    [Refereed]

  • Asanuma H, Minamino T, Sanada S, Ogita H, Kim J, Fujita M, Hirata A, Tsukamoto O, Ogai A, Node K, Hori M, Tomoike H, Kitakaze M
    2005, J Mol Cell Cardiol, 39, 605 - 614, English
    [Refereed]
    Scientific journal

  • Shintani Y, Node K, Asanuma H, Sanada S, Takashima S, Asano Y, Liao Y, Fujita M, Hirata A, Shinozaki Y, Fukushima T, Nagamachi Y, Okuda H, Kim J, Tomoike H, Hori M, Kitakaze M
    Dec. 2004, Journal of molecular and cellular cardiology, 37(6) (6), 1213 - 1218
    [Refereed]

  • S Sanada, M Kitakaze
    Nov. 2004, INTERNATIONAL JOURNAL OF CARDIOLOGY, 97(2) (2), 263 - 276, English
    [Refereed]

  • S Sanada, H Asanuma, T Minamino, K Node, S Takashima, H Okuda, Y Shinozaki, A Ogai, M Fujita, A Hirata, JY Kim, Y Asano, H Mori, H Tomoike, S Kitamura, M Hori, M Kitakaze
    Oct. 2004, CIRCULATION, 110(15) (15), 2143 - 2149, English
    [Refereed]
    Scientific journal

  • Are cardiotonic agents cardioprotective?
    Shoji Sanada, Masafumi Kitakaze
    Sep. 2004, Respiration and Circulation, 52(9) (9), 891 - 896, Japanese
    Scientific journal

  • YL Liao, M Asakura, S Takashima, A Ogai, Y Asano, Y Shintani, T Minamino, H Asanuma, S Sanada, J Kim, S Kitamura, H Tomoike, M Hori, M Kitakaze
    Aug. 2004, CIRCULATION, 110(6) (6), 692 - 699, English
    [Refereed]
    Scientific journal

  • S Sanada, H Asanuma, O Tsukamoto, T Minamino, K Node, S Takashima, T Fukushima, A Ogai, Y Shinozaki, M Fujita, A Hirata, H Okuda, H Shimokawa, H Tomoike, M Hori, M Kitakaze
    Jul. 2004, CIRCULATION, 110(1) (1), 51 - 57, English
    [Refereed]
    Scientific journal

  • H Asanuma, T Minamino, S Sanada, S Takashima, H Ogita, A Ogai, M Asakura, YL Liao, Y Asano, Y Shintani, J Kim, Y Shinozaki, H Mori, K Node, S Kitamura, H Tomoike, M Hori, M Kitakaze
    Jun. 2004, CIRCULATION, 109(22) (22), 2773 - 2779, English
    [Refereed]
    Scientific journal

  • Y Asano, S Takashima, M Asakura, Y Shintani, YL Liao, T Minamino, H Asanuma, S Sanada, J Kim, A Ogai, T Fukushima, Y Oikawa, Y Okazaki, Y Kaneda, M Sato, J Miyazaki, S Kitamura, H Tomoike, M Kitakaze, M Hori
    Feb. 2004, NATURE GENETICS, 36(2) (2), 123 - 130, English
    [Refereed]
    Scientific journal

  • Ogita H, Node K, Liao Y, Ishikura F, Beppu S, Asanuma H, Sanada S, Takashima S, Minamino T, Hori M, Kitakaze M
    2004, Hypertension, 43, 237 - 242, English
    [Refereed]
    Scientific journal

  • Asanuma H, Sanada S, Ogai A, Minamino T, Takashima S, Asakura M, Ogita H, Shinozaki Y, Mori H, Node K, Tomoike H, Hori M, Kitakaze M
    2004, J Cardiovasc Pharmacol, 43, 574 - 579, English
    [Refereed]
    Scientific journal

  • Ogita H, Node K, Asanuma H, Sanada S, Kim J, Takashima S, Minamino T, Hori M, Kitakaze M
    2004, J Cardiovasc Pharmacol, 43, 237 - 242, English
    [Refereed]
    Scientific journal

  • Fujita M, Minamino T, Sanada S, Asanuma H, Hirata A, Ogita H, Okada K, Tsukamoto O, Takashima S, Tomoike H, Node K, Hori M, Kitakaze M
    2004, J Mol Cell Cardiol, 37, 1219 - 1223, English
    [Refereed]
    Scientific journal

  • [The trend of research on the mechanism of reperfusion injury].
    Shoji Sanada, Masatsugu Hori, Koichi Node, Masafumi Kitakaze
    Apr. 2003, Nihon rinsho. Japanese journal of clinical medicine, 61 Suppl 4, 135 - 41, Japanese, Domestic magazine
    Scientific journal

  • Sanada S, Node K, Minamino T, Takashima S, Ogai A, Asanuma H, Ogita H, Liao Y, Asakura M, Kim J, Hori M, Kitakaze M
    2003, Hypertension, 41, 963 - 967, English
    [Refereed]
    Scientific journal

  • Asanuma H, Node K, Minamino T, Sanada S, Takashima S, Ueda Y, Sakata Y, Asakura M, Kim J, Ogita H, Tada M, Hori M, Kitakaze M
    2003, J Cardiovasc Pharmacol, 41, 499 - 505, English
    [Refereed]
    Scientific journal

  • Ogita H, Node K, Asanuma H, Sanada S, Takashima S, Minamino T, Soma M, Kim J, Hori M, Kitakaze M
    2003, J Cardiovasc Pharmacol, 41, 964 - 969, English
    [Refereed]
    Scientific journal

  • Asakura M, Takashima S, Asano Y, Honma T, Asanuma H, Sanada S, Shintani Y, Liao Y, Kim J, Ogita H, Node K, Minamino T, Yorikane R, Agai A, Kitamura S, Tomoike H, Hori M, Kitakaze M
    2003, Circ J, 67, 788 - 792, English
    [Refereed]
    Scientific journal

  • Liao Y, Takashima S, Asano Y, Asakura M, Ogai A, Shintani Y, Minamino T, Asanuma H, Sanada S, Kim J, Ogita H, Tomoike H, Hori M, Kitakaze M
    2003, Circ Res, 93, 759 - 766, English
    [Refereed]
    Scientific journal

  • Hisakazu Ogita, Koichi Node, Hiroshi Asanuma, Shoji Sanada, Yulin Liao, Seiji Takashima, Masanori Asakura, Hidezo Mori, Yoshiro Shinozaki, Masatsugu Hori, Masafumi Kitakaze
    Sep. 2002, Journal of the American College of Cardiology, 40(5) (5), 998 - 1005, English
    [Refereed]
    Scientific journal

  • Shoji Sanada, Koichi Node, Hiroshi Asanuma, Hisakazu Ogita, Seiji Takashima, Tetsuo Minamino, Masanori Asakura, Yulin Liao, Akiko Ogai, Jiyoong Kim, Masatsugu Hori, Masafumi Kitakaze
    Sep. 2002, Journal of the American College of Cardiology, 40(5) (5), 991 - 997, English
    [Refereed]
    Scientific journal

  • Opening of the adenosine triphosphate-sensitive potassium channel attenuates cardiac remodeling induced by long-term inhibition of nitric oxide synthesis - Role of 70-kDa S6 kinase and extracellular signal-regulated kinase
    S Sanada, K Node, H Asanuma, H Ogita, S Takashima, T Minamino, M Asakura, WL Liao, A Ogai, J Kim, M Hori, M Kitakaze
    Sep. 2002, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 40(5) (5), 991 - 997, English
    [Refereed]
    Scientific journal

  • Masafumi Kitakaze, Hiroshi Asanuma, Hiroharu Funaya, Koichi Node, Seiji Takashima, Shoji Sanada, Masanori Asakura, Hisakazu Ogita, Jiyoong Kim, Masatsugu Hori
    Jul. 2002, Journal of the American College of Cardiology, 40(1) (1), 162 - 166, English
    [Refereed]
    Scientific journal

  • S Takashima, M Kitakaze, M Asakura, H Asanuma, S Sanada, F Tashiro, H Niwa, J Miyazaki, S Hirota, Y Kitamura, T Kitsukawa, H Fujisawa, M Klagsbrun, M Hori
    Mar. 2002, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 99(6) (6), 3657 - 3662, English
    [Refereed]
    Scientific journal

  • M Asakura, M Kitakaze, S Takashima, Y Liao, F Ishikura, T Yoshinaka, H Ohmoto, K Node, K Yoshino, H Ishiguro, H Asanuma, S Sanada, Y Matsumura, H Takeda, S Beppu, M Tada, M Hori, S Higashiyama
    Jan. 2002, NATURE MEDICINE, 8(1) (1), 35 - 40, English
    [Refereed]
    Scientific journal

  • [Amelioration of ischemia- and reperfusion-induced myocardial injury by the selective estrogen receptor modulator, raloxifene, in the canine heart].
    Ogita H, Node K, Asanuma H, Sanada S, Takashima S, Asakura M, Kitakaze M, Hori M
    Jan. 2002, Journal of cardiology, 39(1) (1), 55 - 56
    [Refereed]

  • Liao Y, Ishikura F, Beppu S, Asakura M, Takashima S, Asanuma H, Sanada S, Kim J, Ogita H, Kuzuya T, Node K, Kitakaze M, Hori M
    2002, Am J Physiol Heart Circ Physiol, 282, H1703-H1708, English
    [Refereed]
    Scientific journal

  • Asakura M, Kitakaze M, Sakata Y, Asanuma H, Sanada S, Kim J, Ogita H, Liao Y, Node K, Takashima S, Tada M, Hori M
    2002, Circ J, 66, 93 - 96, English
    [Refereed]
    Scientific journal

  • Sanada S, Kitakaze M, Asanuma H, Papst PJ, Node K, Liao Y, Shinozaki Y, Ogita H, Takashima S, Sakata Y, Asakura M, Kuzuya T, Terada N, Mori H, Hori M
    Oct. 2001, Circulation, 104, 705 - 710, English
    [Refereed]
    Scientific journal

  • Nifedipine limits infarct size via NO-dependent mechanisms in dogs.
    H Asanuma, M Kitakaze, H Funaya, S Takashima, T Minamino, K Node, Y Sakata, M Asakura, S Sanada, Y Shinozaki, H Mori, T Kuzuya, M Tada, M Hori
    OBJECTIVES: Amlodipine increases NO levels in coronary vessels and aorta via bradykinin-dependent mechanisms in vitro. We have previously reported that nifedipine increases cardiac NO levels in the ischemic canine hearts, suggesting that nifedipine may also have protective effects against ischemia and reperfusion injury, because the enhancement of NO production limits infarct size. We tested whether nifedipine limits infarct size via NO-dependent mechanisms. METHODS: In open chest dogs, the left anterior descending coronary artery was perfused with blood through a bypass tube and occluded for 90 min followed by 6 hours of reperfusion. Infarct size was assessed at 6 hours of reperfusion. Nifedipine of 3 or 6 microg/kg/min was infused into the bypass tube between 10 min prior to the onset of ischemia and 60 min of reperfusion. RESULTS: Neither systemic blood pressure nor heart rate changed during infusion of nifedipine. Infarct size was reduced by the administration of nifedipine (3 or 6 microg/kg/min) compared with the untreated condition (25.6+/-2.6 and 19.1+/-3.5 vs. 43.4+/-5.6%, respectively), which was completely blunted by L-NAME (45.0+/-3.6 and 45.4+/-4.2 vs. 47.9+/-3.9% in the nifedipine (3 or 6 microg/kg/min) with L-NAME groups vs. the L-NAME group). Myeloperoxidase activity of the myocardium increased after 6 hours of reperfusion, which was attenuated by nifedipine. The limitation of infarct size and the attenuation in myeloperoxidase actiivity were completely blunted by L-NAME. There were no significant differences in collateral blood flow at 45 min of ischemia between each group. CONCLUSIONS: We conclude that the Ca channel blocker, nifedipine, limits infarct size via NO-dependent mechanisms.
    Sep. 2001, Basic research in cardiology, 96(5) (5), 497 - 505, English, International magazine
    Scientific journal

  • M Kitakaze, K Node, S Takashima, H Asanuma, M Asakura, S Sanada, Y Shinozaki, H Mori, H Sato, T Kuzuya, M Hori
    Sep. 2001, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 33(9) (9), 1727 - 1737, English
    [Refereed]
    Scientific journal

  • Role of Phasic Dynamism of P38 Mitogen-activated Protein Kinase Activation in the Ischemic Preconditioning on the Canine Heart.
    Sanada S, Kitakaze M, Papst PJ, Hatanaka K, Asanuma H, Aki T, Shinozaki Y, Ogita H, Node K, Takashima S, Asakura M, Kuzuya T, Mori H, Terada N, Yoshida Ki, Hori M
    Jul. 2001, Circ Res., 88, 175 - 180, English
    [Refereed]
    Scientific journal

  • Kitakaze M, Asakura M, Sakata Y, Asanuma H, Sanada S, Kuzuya T, Miyazaki J, Takashima S, Hori M
    Mar. 2001, Cardiovasc Drugs Ther, 15: 125-130, English
    Scientific journal

  • Benidipine, a long-acting Ca channel blocker, limits infarct size via bradykinin- and NO-dependent mechanisms in canine hearts.
    H Asanuma, M Kitakaze, K Node, S Takashima, Y Sakata, M Asakura, S Sanada, Y Shinozaki, H Mori, M Tada, T Kuzuya, M Hori
    Amlodipine increases NO levels in coronary vessels and aorta via bradykinin-dependent mechanisms in vitro. We have previously reported that a long-acting Ca channel blocker, benidipine, increases cardiac NO levels in ischemic canine hearts, suggesting that benidipine may also protect against ischemia and reperfusion injury via bradykinin- and NO-dependent mechanisms. We examined this possibility. In open chest dogs, the left anterior descending coronary artery was perfused with blood through a bypass tube and was occluded for 90 min followed by 6 hours of reperfusion. Infarct size was assessed by TTC staining at 6 hours of reperfusion. When benidipine doses of 50, 100, and 200 ng/kg/min were infused via the bypass tube between 10 min prior to the onset of ischemia and after 60 min of reperfusion, systemic blood pressure did not change significantly. Infarct size decreased with the administration of benidipine (50, 100, and 200 ng/kg/min) when compared to the untreated condition (24.8+/-2.5, 17.3+/-3.1, and 16.5+/-2.0 vs. 43.4+/-5.6%, respectively) associated with the increased release of NO and bradykinin in the coronary venous blood upon reperfusion. Myeloperoxidase activity of the myocardium increased after 6 hours of reperfusion, which was attenuated by benidipine. The limitation of infarct size and the increase in myeloperoxidase activity were completely blunted by either L-NAME or HOE140. There were no significant differences in collateral blood flow assessed by the microsphere method after 45 min of ischemia for any of the groups. Thus, we conclude that the Ca channel blocker, benidipine, limits infarct size via bradykinin- and NO-dependent mechanisms.
    2001, Cardiovascular drugs and therapy, 15(3) (3), 225 - 31, English, International magazine
    Scientific journal

  • Sanada S, Kitakaze M, Asanuma H, Harada K, Ogita H, Node K, Takashima S, Sakata Y, Asakura M, Shinozaki Y, Mori H, Kuzuya T, Hori M
    2001, Am J Physiol Heart Circ Physiol, 280, H256-H263, English
    [Refereed]
    Scientific journal

  • Sanada S, Kitakaze M, Node K, Takashima S, Ogai A, Asanuma H, Sakata Y, Asakura M, Ogita H, Liao Y, Fukushima T, Yamada J, Minamino T, Kuzuya T, Hori M
    2001, Hypertension, 38, 404 - 411, English
    [Refereed]
    Scientific journal

  • KITAKAZE Masafumi, SANADA Shoji, ASANUMA Hiroshi, NODE Koichi, MINAMINO Tetsuo, TAKASHIMA Seiji, CHUJO Mitsuaki, SHINOZAKI Yoshiro, MORI Hidezo, KUZUYA Tsunehiko, HORI Masatsugu
    先行する短時間心筋虚血 (ischemic preconditioning) は, 長時間虚血により生じる心筋壊死サイズを縮小する.本研究では, 麻酔開胸イヌを用いそのメカニズムを検討した.その結果, 1) ischemic preconditioningによる心筋梗塞サイズ縮小効果には, アデノシン産生酵素活性化が関与する, 2) protein kinase C活性化に加えてATP感受性K+チャネル開口がアデノシン産生酵素活性化に関与する, 3) 細胞膜・ミトコンドリアに存在するATP感受性K+チヤネルが独立して相加的にischemic preconditioningに関与する, ことが明らかになった.以上の結果より, ischemic preconditioningによる心筋保護作用にはアデノシンーアデノシン産生酵素・protein kinase C・ATP感受性K+チャネル開口が連関している可能性が示された.
    The Japanese Society of Electrocardiology, Mar. 2000, Japanese Journal of Electrocardiology, 20(2) (2), 103 - 111, Japanese

  • Nifedipine-induced coronary vasodilation in ischemic hearts is attributable to bradykinin- and NO-dependent mechanisms in dogs.
    Kitakaze M, Asanuma H, Takashima S, Minamino T, Ueda Y, Sakata Y, Asakura M, Sanada S, Kuzuya T, Hori M
    Feb. 2000, Circulation, English
    [Refereed]
    Scientific journal

  • T. Yamada, M. Fukunami, T. Shimonagata, K. Kumagai, S. Sanada, H. Ogita, Y. Asano, M. Hori, N. Hoki
    Feb. 1999, European Heart Journal, 20(3) (3), 211 - 220, English
    [Refereed]
    Scientific journal

  • Increased expression of P-selectin on platelets is a risk factor for silent cerebral infarction in patients with atrial fibrillation: role of nitric oxide.
    Minamino T, Kitakaze M, Sanada S, Asanuama H, Kurotobi T, Koretsune Y, Fukunami M, Kuzuya T, Hoki N, Hori M
    Oct. 1998, Circulation, 33(2) (2), 103 - 104, English
    [Refereed]
    Scientific journal

  • Increased expression of P-selectin on platelets is a risk factor for silent cerebral infarction in patients with atrial fibrillation - Role of nitric oxide
    T Minamino, M Kitakaze, S Sanada, H Asanuama, T Kurotobi, Y Koretsune, M Fukunami, T Kuzuya, N Hoki, M Hori
    Oct. 1998, CIRCULATION, 98(17) (17), 1721 - 1727, English
    [Refereed]
    Scientific journal

  • Yamada T, Fukunami M, Shimonagata T, Kumagai K, Kim J, Sanada S, Ogita H, Hori M, Hoki N
    1998, Heart, 79, 256 - 261, English
    [Refereed]
    Scientific journal

  • Prediction of transition to chronic atrial fibrillation in patients with paroxysmal atrial fibrillation by signal-averaged electrocardiography: a prospective study.
    Abe Y, Fukunami M, Yamada T, Ohmori M, Shimonagata T, Kumagai K, Kim J, Sanada S, Hori M, Hoki N
    Nov. 1997, Circulation, 96, 2612 - 2616, English
    [Refereed]
    Scientific journal

  • Takahisa Yamada, Masatake Fukunami, Kazuaki Kumagai, Yasushi Abe, Jiyoong Kim, Shoji Sanada, Masatsugu Hori, Takenobu Kamada, Noritake Hoki
    Elsevier USA, 1996, Journal of the American College of Cardiology, 28(3) (3), 738 - 744, English
    [Refereed]
    Scientific journal

■ MISC
  • 臨床研究法で定義される「研究開発計画支援担当者」および「調整管理実務担当者」のコア・コンピテンシー・モデルの開発に関する研究
    岩崎 幸司, 今野 浩一, 菊地 佳代子, 大塚 佑基, 松山 琴音, 秦 友美, 真田 昌爾
    ライフサイエンス出版(株), Jul. 2020, 薬理と治療, 48(Suppl.1) (Suppl.1), s65 - s80, Japanese
    [Refereed]

  • Establishment of Indicators and Outcome Prediction Model of Acute Cardiovascular Diseases to Improve Cardiovascular Medical Service System
    坂田 泰史, 磯部 光章, 安田 聡, 宮本 恵宏, 西村 邦宏, 添田 恒有, 今村 知明, 平山 篤志, 辻田 賢一, 中尾 浩一, 森野 禎浩, 上田 裕一, 高山 守正, 島村 和男, 土肥 智晴, 岡田 佳築, 真田 昌爾, 彦惣 俊吾, 小室 一成
    (一社)日本循環器学会, Mar. 2019, 日本循環器学会学術集会抄録集, 83回, SY24 - 1, English

  • わが国の循環器医療提供体制の課題と展望 望ましい体制を構築するための急性冠症候群および急性大動脈症候群の医療体制を示す指標を創造する試み(Efforts on Creating Index of Medical Service System for Acute Coronary Syndrome and Acute Aortic Syndrome to Construct Desirable System)
    坂田 泰史, 磯部 光章, 安田 聡, 宮本 恵宏, 西村 邦宏, 中村 文明, 斎藤 能彦, 今村 知明, 平山 篤志, 辻田 賢一, 中尾 浩一, 森野 禎浩, 上田 裕一, 高山 守正, 真田 昌爾, 彦惣 俊吾, 小室 一成
    (一社)日本循環器学会, Mar. 2018, 日本循環器学会学術集会抄録集, 82回, SY11 - 4, English

  • Quality by Designによる質の高い臨床研究実施計画書作成を志向するツール作成の試み
    松山 琴音, 松嶋 由紀子, 林 宏至, 真田 昌爾, 須崎 友紀, 長尾 典明, 小澤 郷司, 吉田 浩輔, 岩崎 幸司, 山本 学, 山口 拓洋, 上村 尚人
    (一社)日本臨床薬理学会, Nov. 2017, 臨床薬理, 48(Suppl.) (Suppl.), S269 - S269, Japanese

  • フェーズ1試験において健康男性に心電図上観察された食事性二相性T波変化に関する報告
    姚 香景, 中谷 大作, 真田 昌爾, 砂 真一郎, 川村 陽子, 玉井 克人, 山本 洋一, 竹原 徹郎, 名井 陽, 西田 幸二
    (一社)日本臨床薬理学会, Oct. 2016, 臨床薬理, 47(Suppl.) (Suppl.), S301 - S301, Japanese

  • Cardiac-specific Overexpression of ER Chaperone GRP78 Attenuates Doxorubicin-Induced Cardiac Dysfunction
    Haiying Fu, Takashi Matsuzaki, Shoji Sanada, Tetsuo Minamino
    Oct. 2014, JOURNAL OF CARDIAC FAILURE, 20(10) (10), S185 - S185, English
    Summary international conference

  • Prevalence and Relation of Left Ventricular Diastolic Dysfunction and Hypertrophy in a Community-Based Population
    Takuya Hasegawa, Masanori Asakura, Hideaki Kanzaki, Jiyoong Kim, Hiroshi Asanuma, Shoji Sanada, Akira Funada, Makoto Amaki, Hiroyuki Takahama, Takahiro Ohara, Toshihisa Anzai, Masafumi Kitakaze
    Nov. 2012, CIRCULATION, 126(21) (21), English
    Summary international conference

  • Novel synthesized radical-containing nanoparticles augment cardioprotection after ischemia-reperfusion injury via nitric oxide in canine hearts
    A. Yoshida, S. Sanada, H. Asanuma, H. Sasaki, H. Takahama, M. Asakura, T. Yoshitomi, Y. Nagasaki, M. Kitakaze
    Aug. 2012, EUROPEAN HEART JOURNAL, 33, 957 - 957, English
    Summary international conference

  • Shoji Sanada, Masafumi Kitakaze, Issei Komuro
    2012, Circulation Journal, 76(2) (2), 299 - 300, English
    Book review

  • Shoji Sanada, Issei Komuro, Masafumi Kitakaze
    Nov. 2011, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 301(5) (5), H1723 - H1741, English
    Book review

  • Inhaled hydrogen gas therapy reduced infarct size via mitochondrial KATP channels and mitochondrial permeability transition pore in a dog model of myocardial ischemia reperfusion injury
    A. Yoshida, H. Asanuma, S. Sanada, S. Yamazaki, S. Takashima, T. Minamino, M. Asakura, N. Mochizuki, M. Kitakaze
    Aug. 2011, EUROPEAN HEART JOURNAL, 32, 577 - 577, English
    Summary international conference

  • Effect of Vildagliptin on the Improvement of Survival in Murine Pressure-Overload Heart Failure Model
    Ayako Takahashi, Masanori Asakura, Min Kyung-Duk, Shin Ito, Tetsuo Minamino, Yin Yan, Satoru Yamazaki, Shoji Sanada, Hiroshi Asanuma, Yulin Liao, Seiji Takashima, Naoki Mochizuki, Masafumi Kitakaze
    Nov. 2010, CIRCULATION, 122(21) (21), English
    Summary international conference

  • Shoji Sanada, Masafumi Kitakaze
    Nov. 2010, CIRCULATION JOURNAL, 74(11) (11), 2288 - 2289, English
    Others

  • Inhalation of hydrogen gas reduced infarct size following ischemia and reperfusion via mitochondrial KATP channels in canine hearts
    A. Yoshida, H. Asanuma, H. Sasaki, S. Sanada, S. Yamazaki, S. Takashima, T. Minamino, M. Asakura, M. Kitakaze
    Sep. 2010, EUROPEAN HEART JOURNAL, 31, 42 - 42, English
    Summary international conference

  • Cardiac I-123 Metaiodobenzylguanidine Imaging Provides Additional Prognostic Power to Seattle Heart Failure Model in Patients With Chronic Heart Failure: A 10-year Follow-up Comparative Study
    Yuki Kuramoto, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shoji Sanada, Yoshio Furukawa, Koji Tanaka, Yusuke Iwasaki, Taku Yasui, Hiromichi Ueda, Masato Kawasaki, Takeshi Okada, Shunsuke Tamaki, Wayne C. Levy, Masatake Fukunami
    Nov. 2009, CIRCULATION, 120(18) (18), S861 - S861, English
    Summary international conference

  • 運動負荷によりST上昇を認めアセチルコリン負荷にて診断された運動誘発性冠攣縮性狭心症の1例
    安居 琢, 奥山 裕司, 山田 貴久, 森田 孝, 真田 昌爾, 古川 善郎, 増田 正晴, 岩崎 祐介, 上田 宏達, 岡田 健志, 川崎 真佐登, 福並 正剛
    (一社)日本循環器学会, Apr. 2009, Circulation Journal, 73(Suppl.II) (Suppl.II), 944 - 944, Japanese

  • 極端な1度AV blockのため両室ペーシング率が低下し心不全増悪に陥ったCRT-D植え込み後の拡張型心筋症の1例
    岡田 健志, 奥山 裕司, 古川 善郎, 森田 孝, 真田 昌爾, 増田 正晴, 岩崎 祐介, 安居 琢, 上田 宏達, 川崎 真佐登, 山田 貴久, 福並 正剛
    (一社)日本循環器学会, Apr. 2009, Circulation Journal, 73(Suppl.II) (Suppl.II), 945 - 945, Japanese

  • Oxidized Low-Density Lipoprotein Levels is a Good Predictor of the Response to Atorvastatin Therapy in Patients with Chronic Heart Failure
    Yamada Takahisa, Okuyama Yuji, Morita Takashi, Sanada Shoji, Furukawa Yoshio, Masuda Masaharu, Iwasaki Yusuke, Yasui Taku, Ueda Hiromichi, Okada Takeshi, Kawasaki Masato, Fukunami Masatake
    Japanese Circulation Society, 01 Mar. 2009, Circulation journal : official journal of the Japanese Circulation Society, 73(0) (0), 347 - 347, English
    Summary national conference

  • The Optimal Antithrombotic Therapy for Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention With Stenting
    Yusuke Iwasaki, Masatake Fukunami, Takahisa Yamada, Yuji Okuyama, Takasi Morita, Shoji Sanada, Yoshio Furukawa, Masaharu Masuda, Taku Yasui, Hiromichi Ueda, Takeshi Okada, Masato Kawasaki
    Mar. 2009, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(10) (10), A429 - A429, English
    Summary international conference

  • METFORMIN THERAPY IS ASSOCIATED WITH IMPROVED CARDIAC FUNCTION AND IMPROVED INSULIN RESISTANCE IN DOGS
    Hideyuki Sasaki, Hiroshi Asanuma, Masashi Fujita, Hiroyuki Takahama, Shin Ito, Masanori Asakura, Jiyoong Kim, Tetsuo Minamino, Seiji Takashima, Shoji Sanada, Kyongduk Min, Kazuo Komamura, Masaru Sugumachi, Naoki Mochizuki, Masafumi Kitakaze
    2009, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 316 - 316, English
    Summary international conference

  • 古川 善郎, 奥山 裕司, 山田 貴久, 森田 孝, 真田 昌爾, 増田 正晴, 岩崎 祐介, 安居 琢, 上田 宏達, 岡田 健志, 川崎 真佐登, 福並 正剛
    (一社)日本不整脈心電学会, Oct. 2008, 心電図, 28(5) (5), 474 - 474, Japanese
    Introduction scientific journal

  • Management of Hyperphosphatemia Is an Important Novel Therapeutic Target In Chronic Heart Failure
    Hiroshi Asanuma, Masanori Asakura, Jiyoong Kim, Hiroyuki Takahama, Hideyuk Sasaki, Shoji Sanada, Takahiro Ohara, Kyondoku Min, Shin Ito, Masashi Fujita, Yoshihiro Asano, Seiji Takashima, Tetsuo Minamino, Kazuo Komamura, Masafumi Kitakaze
    Oct. 2008, CIRCULATION, 118(18) (18), S433 - S434, English
    Summary international conference

  • The Effects of Anglotensin II Receptor Blockade on Atrial Late Potential in Paroxysmal Atrial Fibrillation Patients with Hypertension
    Takashi Morita, Takahisa Yamada, Yuji Okuyama, Shoji Sanada, Yoshio Furukawa, Masaharu Masuda, Yusuke Iwasaki, Taku Yasul, Hiromichi Ueda, Takeshi Okada, Masato Kawasaki, Masatake Fukunami
    Oct. 2008, CIRCULATION, 118(18) (18), S829 - S829, English
    Summary international conference

  • Usefulness of Cardiac I-123 Metalodobenzylguanidine Imaging for Predictor of Sudden Cardiac Death in Chronic Heart Failure Patients with Mild to Moderate Systolic Dysfunction : A 10-Year Follow up Study
    Hiromichi Ueda, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shoji Sanada, Yoshio Furukawa, Masaharu Masuda, Yusuke Iwasaki, Taku Yasui, Takeshi Okada, Masato Kawasaki, Masataka Fukunami
    Oct. 2008, CIRCULATION, 118(18) (18), S1067 - S1067, English
    Summary international conference

  • Activation of Myocardial AMP-activated Protein Kinase by Metformin Prevents Progression of Heart Failure in Dogs; Involvement of eNOS Activation
    Hideyuki Sasaki, Hiroshi Asanuma, Masashi Fujita, Hiroyuki Takahama, Masanori Asakura, Jiyoong Kim, Tetsuo Minamino, Seiji Takashima, Shoji Sanada, Shin Ito, Kyungduk Min, Kazuo Komamura, Naoki Mochizuki, Masafumi Kitakaze
    Oct. 2008, CIRCULATION, 118(18) (18), S286 - S287, English
    Summary international conference

  • Clinical Significance of Serial Studies of Cardiac I-123 Metaiodobenzylguanidine Imaging for the Prediction of Sudden Death in Patients with Chronic Heart Failure
    Takeshi Okada, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shoji Sanada, Yoshio Furukawa, Masaharu Masuda, Yusuke Iwasaki, Taku Yasui, Hiromichi Ueda, Masato Kawasaki, Masatake Fukunami
    Oct. 2008, CIRCULATION, 118(18) (18), S1066 - S1067, English
    Summary international conference

  • Cardiac I-123 metaiodobenzylguanidine imaging predicts the risk of cardiac death in patients with chronic heart failure, irrespective of renal dysfunction. A prospective 10-year follow up study
    Yusuke Iwasaki, Takahisa Yamada, Yuji Okuyama, Takasi Morita, Yoshio Furukawa, Shoji Sanada, Yasumasa Tsukamoto, Keiji Okuda, Masaharu Masuda, Taku Yasui, Masataka Fukunami
    Mar. 2008, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 51(10) (10), A160 - A160, English
    Summary international conference

  • The combination of cardiac I-123 metaiodobenzylguanidine and subclinical hypothyroidism identifies patients with chronic heart failure at higher risk for poor outcome
    Taku Yesui, Takahisa Yamada, Yuji Okuyama, Takasi Morita, Shoji Sanada, Yoshio Furukawa, Yasumasa Tsukamoto, Keiji Okuda, Masaharu Masuda, Yusuke Iwasaki, Masatake Fukunami
    Mar. 2008, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 51(10) (10), A172 - A172, English
    Summary international conference

  • Activation of A(1) adenosine receptors inhibits the adrenal aldosterone production and attenuates severity of heart failure
    Osamu Tsukamoto, Tetsuo Minamino, Shoji Sanada, Hidetoshi Okazaki, Ichiro Hisatome, Seiji Takashima, Yasunori Shintani, Yoshihiro Asano, Masafumi Kitakaze
    Oct. 2006, CIRCULATION, 114(18) (18), 440 - 440, English
    Summary international conference

  • Nongenomic effects of alclosterone on ischemic hearts via PKC-dependent pathways
    M Fujita, T Minamino, S Takashima, H Asanuma, S Sanada, A Hirata, M Wakeno, M Myoishi, H Okuda, M Hori, M Kitakaze, A Ogai
    Oct. 2005, CIRCULATION, 112(17) (17), U76 - U76, English
    Summary international conference

  • Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs
    A Hirata, T Minamino, H Asanuma, S Sanada, M Fujita, M Wakeno, Y Nagamachi, S Takashima, Y Asano, M Hori, M Kitakaze
    Oct. 2005, CIRCULATION, 112(17) (17), U255 - U255, English
    Summary international conference

  • Neovascularization by Erythropoietin Contributes to the Preservation of Left Ventricular Function after Coronary Artery Ligation in Conscious Beagle Dogs(Angiogenesis 4 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
    Hirata Akio, Minamino Tetsuo, Asanuma Hiroshi, Sanada Shoji, Fujita Masashi, Wakeno Masakatsu, Myoishi Masafumi, Tsukamoto Osamu, Okada ken-ichiro, Komamura Kazuo, Hori Masatsugu, Kitakaze Masafumi
    Japanese Circulation Society, 01 Mar. 2005, Circulation journal : official journal of the Japanese Circulation Society, 69, 493 - 494, English

  • Nongenomic Deleterious Effects of Aldosterone on Ischemic Hearts via PKC-Dependent Pathway in Dogs(Coronary Circulation, Basic/Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
    Fujita Masashi, Minamino Tetsuo, Asanuma Hiroshi, Sanada Shoji, Hirata Akio, Wakeno Masakatsu, Myoishi Masafumi, Okada Ken-ichiro, Tsukamoto Osamu, Okuda Hiroko, Tomoike Hitonobu, Hori Masatsugu, Kitakaze Masafumi
    Japanese Circulation Society, 01 Mar. 2005, Circulation journal : official journal of the Japanese Circulation Society, 69, 468 - 468, English

  • OJ-442 Gq-stimulation along with low activity of proteasome induces cardiac apoptosis : Potential mechanism of transition from hypertrophy to failure(Heart Failure, Basic 3 (M) : OJ54)(Oral Presentation (Japanese))
    Tsukamoto Osamu, Minamino Tetsuo, Takashima Seiji, Okada Kenichiro, Hirata Akio, Fujita Masashi, Shintani Yasunori, Asano Yoshihiro, Sanada Shoji, Asanuma Hiroshi, Ri Ken, Liao Yulin, Takashima Seiji, Hori Masatsugu, Kitakaze Masafumi
    Japanese Circulation Society, 01 Mar. 2004, Circulation journal : official journal of the Japanese Circulation Society, 68, 337 - 337, English

  • Active LBP/p40-Retropseudogene interacting with heterochromatin protein 1 causes right ventricular dysplasia
    Y Asano, S Takashima, M Asakura, Y Shintani, YL Liao, T Minamino, S Sanada, T Fukushma, M Hori, M Kitakaze
    Oct. 2003, CIRCULATION, 108(17) (17), 32 - 32, English
    Summary international conference

  • Protein kinase A-induced Rho-kinase inhibition as a novel mediator of ischemic preconditioning independent of protein kinase C
    S Sanada, H Asanuma, O Tsukamoto, S Takashima, Y Liao, T Fukushima, Y Okuda, Y Shinozaki, K Node
    Oct. 2003, CIRCULATION, 108(17) (17), 186 - 186, English
    Summary international conference

  • Selective estrogen receptor modulator raloxifene inhibits the cardiac hypertrophy and dysfunction due to aortic banding in mice
    H Ogita, K Node, H Asanuma, S Sanada, S Takashima, T Minamino, M Asakura, J Kim, Y Liao, Y Asano, Y Shintani, K Okada, M Fujita, A Hirata, O Tsukamoto, M Hori, M Kitakaze
    Mar. 2003, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 41(6) (6), 228A - 228A, English
    Summary international conference

  • Preischemic Protein Kinase-A Activation Evokes Ischemic Preconditioning through Rho-Kinase Inhibition Independent of Protein Kinase-C : A Novel Mechanism
    Sanada Shoji, Node Koichi, Asanuma Hiroshi, Ogita Hisakazu, Kim Jiyoong, Minamino Tetsuo, Takashima Seiji, Fukushima Tomi, Shinozaki Yoshiro, Asakura Masanori, Ogai Akiko, Mori Hidezo, Shimokawa Hiroaki, Hori Masatsugu, Kitakaze Masafumi
    Japanese Circulation Society, 01 Mar. 2003, Circulation journal : official journal of the Japanese Circulation Society, 67, 87 - 87, English

  • Preischemic Protein Kinase-A Activation Triggers Cardioprotection of Ischemic Preconditioning via the Inhibition of Rho-Kinase
    Sanada Shoji, Node Koichi, Asanuma Hiroshi, Ogita Hisakazu, Shintani Yasunori, Minamino Tetsuo, Takashima Seiji, Asakura Masanori, Shinozaki Yoshiro, Mori Hidezo, Shimokawa Hiroaki, Hori Masatsugu, Kitakaze Masafumi
    Japanese Circulation Society, 01 Mar. 2003, Circulation journal : official journal of the Japanese Circulation Society, 67, 303 - 303, English

  • Opening of ATP-Sensitive Potassium Channel Attenuates Cardiac Remodeling Induced by Chronic Inhibition of Nitric Oxide Synthesis
    SANADA Shoji, NODE Koichi, ASANUMA Hiroshi, OGITA Hisakazu, TAKASHIMA Seiji, MINAMINO Tetsuo, ASAKURA Masanori, HORI Masatsugu, KITAKAZE Masafumi
    15 Jan. 2003, Journal of cardiology, 41(1) (1), 43 - 44, Japanese

  • Pravastatin selectively increases coronary blood flow during coronary hypoperfusion through the activation of nitric oxide synthesis in dogs
    S Sanada, H Asanuma, H Ogita, Y Shintani, YL Liao, T Minamino
    Nov. 2002, CIRCULATION, 106(19) (19), 13 - 13, English
    Summary international conference

  • イヌDNAマイクロアレイを用いた慢性心不全の循環生理・分子生物学的病態解析
    浅沼 博司, 朝倉 正紀, 野出 孝一, 高島 成二, 南野 哲男, 真田 昌爾, 扇田 久和, 朝野 仁裕, 新谷 泰範, 堀 正二, 北風 政史
    (一社)日本心臓病学会, Aug. 2002, Journal of Cardiology, 40(Suppl.1) (Suppl.1), 150 - 150, Japanese

  • Ca2+感受性K+チャネル開口薬(NS1619)の心筋虚血・再灌流障害抑制効果
    新谷 泰範, 野出 孝一, 浅沼 博司, 真田 昌爾, 扇田 久和, 高島 成二, 朝倉 正紀, 南野 哲男, 朝野 仁裕, 堀 正二, 北風 政史
    (一社)日本心臓病学会, Aug. 2002, Journal of Cardiology, 40(Suppl.1) (Suppl.1), 224 - 224, Japanese

  • 虚血心におけるアンジオテンシン変換酵素阻害薬とアンジオテンシンII受容体拮抗薬の併用効果 冠血流増加,心筋収縮・代謝不全改善作用
    浅沼 博司, 野出 孝一, 高島 成二, 南野 哲男, 朝倉 正紀, 真田 昌爾, 扇田 久和, 朝野 仁裕, 新谷 泰範, 堀 正二, 北風 政史
    (一社)日本心臓病学会, Aug. 2002, Journal of Cardiology, 40(Suppl.1) (Suppl.1), 383 - 383, Japanese

  • 虚血プレコンディショニング現象におけるPKA活性化の意義 一過性p38MARK活性化の役割
    真田 昌爾, 北風 政史, 野出 孝一, 浅沼 博司, 扇田 久和, 新谷 泰範, 高島 成二, 南野 哲男, 朝倉 正紀, 朝野 仁裕
    日本適応医学会, Jun. 2002, 適応医学, 6(1) (1), 25 - 25, Japanese

  • A Role of Transient Preischemic Activation of Protein Kinase-A in Ischemic Preconditioning in Vivo : Involvement of p38 Mitogen-activated Protein Kinase
    Sanada Shoji, Node Koichi, Asanuma Hiroshi, Ogita Hisakazu, Shintani Yasunori, Takashima Seiji, Asakura Masanori, Asano Yoshihiro, Minamino Tetsuo, Hori Masatsugu, Kitakaze Masafumi
    Japanese Circulation Society, 31 Mar. 2002, Circulation journal : official journal of the Japanese Circulation Society, 66, 697 - 697, English

  • Rho-kinase Inhibitiors Administered After the Onset of Reperfusion Limit Infarct Size : A Novel Strategy for Adjunctive Therapies Against Myocardial Infarction
    Sanada Shoji, Node Koichi, Asanuma Hiroshi, Ogita Hisakazu, Takashima Seiji, Asakura Masanori, Shintani Yasunori, Asano Yoshihiro, Minamino Tetsuo, Hori Masatsugu, Kitakaze Masafumi
    Japanese Circulation Society, 31 Mar. 2002, Circulation journal : official journal of the Japanese Circulation Society, 66, 699 - 699, English

  • The Long-acting Calcium Channel Blockers Attenuate Cardiac Hypertrophy Induced by Chronic NO Inhibition : The Investigation of the Potential Subcellular Mechanisms
    Sanada Shoji, Node Koichi, Minamino Tetsuo, Takashima Seiji, Asakura Masanori, Asanuma Hiroshi, Ogita Hisakazu, Asano Yoshihiro, Shintani Yasunori, Hori Masatsugu, Kitakaze Masafumi
    Japanese Circulation Society, 31 Mar. 2002, Circulation journal : official journal of the Japanese Circulation Society, 66, 442 - 442, English

  • Amlodipine increases coronary blood flow and reduces the severity of myocardial ischemia in canine hearts: Roles of NO and adenosine
    R Asanuma, M Kitakaze, K Node, S Sanada, H Ogita, S Takashima, M Asakura, T Minamino, M Tada, M Hori
    Mar. 2002, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 324A - 324A, English
    Summary international conference

  • Selective serotonin 5HT(2A) receptor inhibition attenuates myocardial ischemia through the increase in nitric oxide production: The alternative role of 5HT(1B) receptor
    S Sanada, M Kitakaze, K Node, H Asanuma, H Ogita, S Takashima, M Asakura, T Minamino, M Hori
    Mar. 2002, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 292A - 292A, English
    Summary international conference

  • A new development of high fidelity canine DNA microarray: Application for the assessment of gene expressions of reversibly or irreversibly injured ischemic myocardium
    M Asakura, M Kitakaze, S Sanada, H Asanuma, S Takashima, T Minamino, K Node, H Ogita, Y Asano, Y Shintani, L Yulin, M Hori
    Mar. 2002, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 299A - 300A, English
    Summary international conference

  • ACE inhibitors and angiotensin II receptor antagonists independently but synergistically increase coronary blood flow and attenuates the severity of contractile and metabolic dysfunction in ischemic hearts
    M Kitakaze, K Node, S Takashima, T Minamino, H Asanuma, M Asakura, J Kim, S Sanada, H Ogita, Y Asano, Y Shintani, M Hori
    Mar. 2002, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 288A - 288A, English
    Summary international conference

  • The selective estrogen receptor modulator, raloxifene, improves the severity of myocardial ischemia in canine hearts
    H Ogita, M Kitakaze, K Node, S Takashima, H Asanuma, M Asakura, S Sanada, Y Asano, Y Shintani, M Hori
    Mar. 2002, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 442A - 443A, English
    Summary international conference

  • Inhibitory effects of the novel antagonist of both GP IIb/IIIa and vitronectin receptors on the formation of coronary thromboemboli caused by an inhibition of adenosine receptors during coronary hypoperfusion in dogs
    H Asanuma, M Kitakaze, K Node, S Sanada, H Ogita, S Takashima, M Asakura, T Minamino, M Tada, M Hori
    Mar. 2002, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 300A - 300A, English
    Summary international conference

  • The selective estrogen receptor modulator, raloxifene, reduces infarct size and ventricular arrhythmias in canine hearts
    H Ogita, M Kitakaze, K Node, H Asanuma, S Sanada, YL Liao, S Takashima, M Asakura, H Mori, Y Shinozaki, M Hori
    Oct. 2001, CIRCULATION, 104(17) (17), 150 - 150, English
    Summary international conference

  • Difference in the subcellular actions of ACE inhibitors and AT1 blockers on attenuating cardiac hypertrophy induced by chronic inhibition of nitric oxide synthesis in vivo
    S Sanada, T Sata, Y Sakata, S Takashima
    Oct. 2001, CIRCULATION, 104(17) (17), 190 - 190, English
    Summary international conference

  • The dihydropyridine Ca channel blocker, nifedipine, limits infarct size via bradykinin- and NO-dependent mechanisms in dogs
    M Kitakaze, Y Shinozaki, H Mori, H Asanuma, S Sanada, M Asakura, H Ogita, YL Liao, K Node, S Takashima, T Kuzuya, M Hori
    Feb. 2001, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 363A - 363A, English
    Summary international conference

  • Ischemia-selective early increase in nitric oxide synthesis confer acute cardioprotection against myocardial infarction afforded by pravastatin
    S Sanada, M Kitakaze, H Asanuma, S Takashima, K Node, H Ogita, M Asakura, YL Liao, T Kuzuya, M Hori
    Feb. 2001, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 363A - 363A, English
    Summary international conference

  • Amelioration of ischemia- and reperfusion-induced myocardial injury by raloxifene: Roles of nitric oxide and the opening of calcium-activated potassium channels
    H Ogita, M Kitakaze, K Node, H Asanuma, S Sanada, S Takashima, M Asakura, YL Liao, Y Shinozaki, H Mori, T Kuzuya, M Hori
    Feb. 2001, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 362A - 363A, English
    Summary international conference

  • A novel inhibitory effect of adenosine on cardiac hypertrophy
    M Asakura, M Kitakaze, S Takashima, S Higashiyama, Y Sakata, H Asanuma, S Sanada, H Ogita, YL Liao, K Node, T Toyofuku, T Kuzuya, M Tada, M Hori
    Feb. 2001, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 272A - 272A, English
    Summary international conference

  • Nitric oxide attenuates angiotensin II-induced activation of p70 S6 kinase and protein synthesis in rat cardiomyocytes via cyclic GMP-dependent mechanisms
    M Kitakaze, H Asanuma, S Sanada, M Asakura, H Ogita, YL Liao, K Node, S Takashima, T Kuzuya, M Hori
    Feb. 2001, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 294A - 295A, English
    Summary international conference

  • Heparin-binding EGF-like growth factor (HB-EGF) plays a critical role in the EGFR transactivation after angiotensin II stimulation in vascular smooth muscle cells
    M Asakura, M Kitakaze, S Takashima, S Higashiyama, H Asanuma, S Sanada, Y Sakata, H Ogita, YL Liao, T Toyofuku, T Kuzuya, M Tada, M Hori
    Feb. 2001, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 270A - 270A, English
    Summary international conference

  • K+チャネル開口薬ニコランジルのNo-reflow現象抑制効果及び心筋梗塞縮小効果の検討
    浅沼博司, 北風政史, 真田昌爾, 高島成二, 野出孝一, 朝倉正紀, 扇田久和, 坂田泰彦, 葛谷恒彦, 多田道彦, 堀正二
    2001, Therapeutic Research, 22, 698 - 700, Japanese
    [Invited]
    Introduction scientific journal

  • アデノシンと心筋保護—プレコンディショニングとの関わり
    真田昌爾, 北風政史, 浅沼博司, 南野哲男, 野出孝一, 高島成二, 朝倉正紀, 扇田久和, 葛谷恒彦, 堀正二
    2001, 日本臨床生理学会雑誌, 31, 73 - 78, Japanese
    [Invited]
    Introduction scientific journal

  • ニコランジル長期投与によりNO欠乏による慢性心肥大が血圧非依存性に抑制される—KATPチャネル開口がp70S6KとERKに及ぼす影響
    真田昌爾, 北風政史, 南野哲男, 野出孝一, 浅沼博司, 坂田泰彦, 朝倉正紀, 扇田久和, 葛谷恒彦, 堀正二
    2001, Therapeutic Research, 22, 708 - 711, Japanese
    [Invited]
    Introduction scientific journal

  • MX68, a new derivative of methotrexate, limits infarct size via adenosine-dependent mechanisms in dogs
    H Asanuma, M Kitakaze, S Sanada, S Takashima, Y Sakata, M Asakura, T Kuzuya, M Hori
    Feb. 2000, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35(2) (2), 370A - 370A, English
    Summary international conference

  • Carvedilol limits infarct size via adenosine-dependent mechanisms in dogs
    H Asanuma, M Kitakaze, S Sanada, S Takashima, Y Sakata, M Asakura, T Kuzuya, M Hori
    Feb. 2000, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35(2) (2), 350A - 350A, English
    Summary international conference

  • Transient exposure of nicotine attenuates the severity of canine myocardial stunning via alpha(1)-adrenergic receptor activation and augmentation of ecto 5 '-nucleotidase activity
    S Sanada, M Kitakaze, H Asanuma, H Ogita, K Harada, S Takashima, Y Sakata, M Asakura, T Kuzuya, M Hori
    Feb. 2000, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35(2) (2), 369A - 369A, English
    Summary international conference

  • The effects of ischemic preconditioning on adenosine deaminase and kinase activities in the canine heart
    M Kitakaze, H Asanuma, S Sanada, S Takashima, Y Ueda, Y Sakata, M Asakura, H Ogita, T Kuzuya, M Hori
    Feb. 2000, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35(2) (2), 401A - 401A, English
    Summary international conference

  • Protein tyrosine kinase is not involved in the infarct size-limiting effect of ischemic preconditioning in canine hearts
    Masafumi Kitakaze, Koichi Node, Hiroshi Asanuma, Seiji Takashima, Yasuhiko Sakata, Masanori Asakura, Shoji Sanada, Yoshiro Shinozaki, Hidezo Mori, Tsunehiko Kuzuya, Masatsugu Hori
    2000, Circ Res, 87, 303 - 308

  • 細胞膜／ミトコンドリアATP感受性K+チャネルは相加的に心筋梗塞サイズ縮小効果を発揮する—麻酔開胸犬での検討
    真田昌爾, 北風政史, 浅沼博司, 扇田久和, 葛谷恒彦, 篠崎芳郎, 盛英三, 堀正二
    2000, Therapeutic Research, 21, 785 - 788, Japanese
    [Invited]
    Introduction scientific journal

  • Both sarcolemmal and mitochondrial ATP-sensitive potassium channels synergistically mimic the infarct size-limiting effect of ischemic preconditioning in the canine heart
    S Sanada, S Takashima, K Harada, Y Shinozaki, H Mori, M Kitakaze
    Nov. 1999, CIRCULATION, 100(18) (18), 717 - 717, English
    Summary international conference

  • Transient exposure to nicotine mediates the infarct size-limiting effect via activation of ecto-5'-nucleotidase. Role of alpha(1)-adrenoceptor activation.
    H Asanuma, S Sanada, H Mori, Y Shinozaki, T Kuzuya
    Nov. 1999, CIRCULATION, 100(18) (18), 838 - 838, English
    Summary international conference

  • Inhibition of p38 mitogen-activated protein kinase blunts the infarct size-limiting effect of ischemic preconditioning in the in vivo canine heart
    S Sanada, S Takashima, Y Sakata, M Asakura, N Terada
    Nov. 1999, CIRCULATION, 100(18) (18), 492 - 492, English
    Summary international conference

  • Increased membrane and soluble P-selectin in atrial fibrillation - Response
    T Minamino, M Kitakaze, S Sanada, H Asanuma, T Kurotobi, Y Koretsune, M Fukunami, T Kuzuya, N Hoki, M Hori
    Oct. 1999, CIRCULATION, 100(17) (17), E86 - E87, English
    Report scientific journal

  • 心嚢液貯留,甲状腺機能異常を認め,血清中に高分子Immunogloblinの過剰発現をみた大動脈炎症候群の1例
    木村 泰之, 高島 成二, 真田 昌爾, 森田 孝, 辻村 英一郎, 坂田 泰史, 山本 一博, 佐藤 洋, 葛谷 恒彦, 桑原 敬介
    (一社)日本循環器学会, 20 Aug. 1999, Japanese Circulation Journal, 63(2) (2), 762 - 762, Japanese

  • Role of opening of ATP-sensitive K^+ channels in cardioprotection afforded by ischemic preconditioning-investigation of cellular mechanisms.
    KITAKAZE M, SANADA S, ASANUMA H, NODE K, MINAMINO T, TAKASHIMA S, CHUJO M, MORI H, KUZUYA T, HORI M
    25 Mar. 1999, 心電図 = Electrocardiology, 19(2) (2), 161 - 169, Japanese

  • Prediction of paroxysmal atrial fibrillation in patients with congestive heart failure by P wave signal-averaged EGG: A prospective study.
    T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki
    Oct. 1998, CIRCULATION, 98(17) (17), 441 - 441, English
    Summary international conference

  • Anatomical basis of QT dispersion in patients with dilated cardiomyopathy
    T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano
    Oct. 1998, CIRCULATION, 98(17) (17), 441 - 441, English
    Summary international conference

  • 0048 I-123MIBG心筋イメージングによる慢性心不全患者の予後評価 : 前向き研究
    扇田 久和, 福並 正剛, 下永田 剛, 熊谷 和明, 山田 貴久, 真田 昌爾, 朝野 仁裕, 伯耆 徳武
    社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62(0) (0), Japanese

  • 0385 心不全悪化の指標としての体表面加算平均心電図P波持続時間の有用性
    朝野 仁裕, 福並 正剛, 下永田 剛, 熊谷 和明, 山田 貴久, 真田 昌爾, 扇田 久和, 伯耆 徳武
    社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62(0) (0), Japanese

  • 0387 失神患者におけるatrial early potentialによる洞不全症候群の検出
    山田 貴久, 福並 正剛, 下永田 剛, 熊谷 和明, 真田 昌爾, 扇田 久和, 朝野 仁裕, 伯耆 徳武
    社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62(0) (0), Japanese

  • P071 慢性心不全患者におけるP波加算平均心電図による発作性心房細動の発症予測 : prospective study
    山田 貴久, 福並 正剛, 下永田 剛, 熊谷 和明, 真田 昌爾, 扇田 久和, 朝野 仁裕, 伯耆 徳武
    社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62(0) (0), Japanese

  • P633 P波加算平均心電図の体表面マッピングによる発作性心房細胞発作に対するPilsicainideの再発予防効果予測
    山田 貴久, 福並 正剛, 下永田 剛, 熊谷 和明, 真田 昌爾, 扇田 久和, 朝野 仁裕, 伯耆 徳武
    社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62(0) (0), Japanese

  • Dobutamine induced late potentials are related to the residual myocardial viability after acute myocardial infarction with reperfusion therapy
    T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki
    Feb. 1998, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2) (2), 447A - 447A, English
    Summary international conference

  • Detection of patients at risk for paroxysmal atrial fibrillation improved by body surface mapping of P-wave signal-averaged ECG
    T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki
    Feb. 1998, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2) (2), 47A - 47A, English
    Summary international conference

  • Prediction of efficacy or pilsicainide to paroxysmal atrial fibrillation by body surface mapping of the P-wave signal-averaged ECG: A prospective study
    T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki
    Feb. 1998, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2) (2), 47A - 47A, English
    Summary international conference

  • Apoptosis of myocardial cell is associated with the abnormal signal-averaged ECG in patients with idiopathic dilated cardiomyopathy
    T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki
    Feb. 1998, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2) (2), 266A - 266A, English
    Summary international conference

  • Prediction of the effectiveness of long-term beta-blocker therapy for dilated cardiomyopathy by signal-averaged electrocardiography: A prospective study
    T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki
    Feb. 1998, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2) (2), 266A - 266A, English
    Summary international conference

  • A prospective study to predict the transition from paroxysmal atrial fibrillation to chronic atrial fibrillation by signal-averaged electrocardiography
    H Ogita, M Fukunami, T Shimonagata, K Kumagai, T Yamada, J Kim, S Sanada, N Hoki
    Feb. 1997, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 29(2) (2), 91218 - 91218, English
    Summary international conference

  • Reproducibility and long-term change of the P wave-triggered signal-averaged ECG
    T Yamada, M Fukunami, T Shimonagata, K Kumagai, J Kim, S Sanada, H Ogita, N Hoki
    Feb. 1997, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 29(2) (2), 91213 - 91213, English
    Summary international conference

  • 拡張型心筋症化した非虚血性心不全と重症心室性不整脈に対しβ遮断薬が有効であった一例
    真田昌爾, 福並正剛, 下永田剛, 熊谷和明, 山田貴久, 扇田久和, 朝野仁裕, 伯耆徳武
    1997, 診療と新薬, 34, 1267 - 1269, Japanese
    [Invited]
    Report scientific journal

■ Research Themes
  • Proposal of a novel pathomechanism of glaucomatous optic neuropathy as dysregulated lactate shuttle and signal transduction and exploration of treatment
    中村 誠, 坂本 麻里, 楠原 仙太郎, 目黒 明, 盛 崇太朗, 真田 昌爾
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2024 - 31 Mar. 2027

  • Development of Effective Multidisciplinary collaboration Workshop on Clinical Trials Support based on Specific and Collaborative Core Compitencies
    真田昌爾, 吉田寿子, 新谷歩, 浅田隆太, 清水忍, 岩崎幸司, 山口拓洋, 高田宗典, 松嶋由紀子, 菊地加代子, 西崎祐史, 出居真由美, 南学, 氏原淳
    AMED, 医療研究開発推進事業費補助金 中央IRB促進事業, Osaka City University Hospital, Apr. 2020 - Mar. 2021, Principal investigator

  • Exploration for Aggravating Process of Heart Failure Induced by Specific Interaction with G-protein-coupled Receptor and Toll-like Receptor
    Sanada Shoji, MINAMINO Tetsuo, HIGO Shuichiro, ASANO Yoshihiro, TSUKAMOTO Osamu
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Osaka University, 01 Apr. 2013 - 31 Mar. 2016
    We and others have reported that ablation of ST2 caused exaggerated cardiac remodeling in both ischemic and non-ischemic HF. We tested whether IL-33 protects myocardium against HF induced by mechanical overload. Following TAC, myocardial mRNA expressions of Th2 cytokines were diminished while those of Th1 were enhanced in IL-33KO mice than in WT mice. After 8-weeks, IL-33KO mice exhibited exacerbated LV hypertrophy, increased chamber dilation, reduced fractional shortening, aggravated fibrosis and impaired survival compared with WT littermates. Accordingly, myocardial mRNA expressions of fibrogenic (TGF-b1/Collagen3a1) as well as hypertrophic (c-Myc/BNP) molecular markers were also significantly enhanced in IL-33KO mice than those in WT mice. In conclusion, the ablation of IL-33 directly and significantly lead to exacerbate cardiac remodeling with impaired cardiac function and survival upon mechanical stress. These data reveal a potential therapeutic role for IL-33 in non-ischemic HF.

  • A New Diagnostics Method for Refractory Heart Failure
    ASANO YOSHIHIRO, HIGO Shuichiro, TSUKAMOTO Osamu, MINAMINO Tetsuo, KATO Hisakazu, OGITA Hisakazu, SANADA Shoji
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Osaka University, 01 Apr. 2012 - 31 Mar. 2015
    Higher order structures in the cell nucleus have been demonstrated to change during development and differentiation. Such structural remodeling occurred in the cell nucleus can be observed as changes in high electron density areas called chromatin by electron microscopy. Alterations in nuclear chromatin structure have been reported some relation with physiological changes. Based on our experimental findings of chromatin remodeling as an upstream of pathological gene expression in cardiomyocytes, we focused on changes in nuclear chromatin structure of cardiomyocytes in patients with dilated cardiomyopathy (DCM). Using our original quantitation methods to analyze the ultrastructure of chromatin, we conducted a retrospective observational study assessing the ability to identify the DCM patients with severe heart failure at risk for poor outcomes, and to make an accurate and an early determination of the indication for some ventricular assist devices to support the failing heart.

  • Role of ER oxidoreductin-1 in cardiovascular remodeling
    MINAMINO TETSUO, HIGO Schuichiro, HAO Hiroyuki, ASANO Yoshihiro, SANADA Shoji, TSUKAMOTO Osamau
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Osaka University, 01 Apr. 2012 - 31 Mar. 2015
    Hypoxic stimuli play important roles in the development of cardiovascular diseases such as ischemic heart disease, atherosclerosis. In the present study, to clarify the role of ER oxidoreductin-1 (Ero1), a major ER oxidase, in the development of abdominal aortic aneurysm, we have tried and succeeded to create Ero1 knockout mice by ES trap method. Interestingly, we found that Ero1 expression increased in human samples from abdominal aortic aneurysm. We also found that continuous infusion of angiotensin II induced abdominal aortic aneurysm in Ero1 knockout, but not normal, mice, suggesting that Ero1 plays an important role in the development of abdominal aortic aneurysm.

  • ブタ心筋梗塞、心不全モデルでの腎動脈周囲高周波焼灼術による心機能改善効果の検討
    中谷 大作, 真田 昌爾, 小室 一成
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 大阪大学, 01 Apr. 2012 - 31 Mar. 2014
    平成25年度の研究実施計画は、ブタ左右腎動脈内に焼灼を実施し、6か月後の腎動脈および腎動脈周囲の傷害の程度を腎動脈造影および病理学的に評価を行うことである。また、腎動脈周囲の交感神経の傷害の程度を生理的に評価するために昇圧反応の有無からアデノシン（一般名：アデノシン三リン酸二ナトリウム）の至適投与量および投与方法の検討を行うことである。 これらを評価、検討するために、2頭のブタ腎動脈に対して、麻酔下に心臓用の不整脈焼灼カテーテルを用いて1頭目右腎動脈に12時方向を６W1分間、左腎動脈に12時方向を４W1分間、2頭目右腎動脈6時方向４W1分間、左腎動脈6時方向６W1分間にそれぞれ焼灼を行った。2頭とも左右腎動脈の近位部と遠位部に焼灼を行った。左右両腎動脈にアデノシンの急速動脈投与および、アデノシンの持続投与を焼灼6か月後にそれぞれ実施した。すべての手技が終了後、ブタを安楽死させ、腎動脈を摘出し、長軸方向に切開し、焼灼部位周辺部を組織固定した。6か月後、腎動脈造影上、いずれの血管においても狭窄像を認めなかった。ブタを安楽死させた直後に採取した腎動脈において、マクロ像として焼灼部位が白く瘢痕化していた（n=1）。組織標本については現在、作成中のため、今後評価予定。アデノシン10mgをゆっくりまたは急速に腎動脈内投与したところ、10秒後に5秒程度の昇圧反応が観察された。この反応は5mg、20mgの急速腎動脈内投与でも観察された。40mgを腎動脈内に急速投与すると5秒後に昇圧反応が観察されたが、その後、徐脈が出現。心臓に同薬剤が到達したために生じたと考えられた。2頭目の豚ではすべての用量においても昇圧反応は観察されなかった。両腎動脈ともアデノシン１γの持続投与により8分後より７～10mmHg程度の昇圧が観察されたが、アデノシン投与中止後も血圧は低下しなかった。

  • Development of image diagnosis and treatment for fluminant myocarditis
    MINAMINO Tetsuo, SANADA Shoji, MATSUZAKI Takashi
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Osaka University, 2011 - 2011
    The prognosis of fluminant myocarditis due to autoimmune myocarditis is poor. Thus, the development of new treatment for fluminant myocarditis is medical unmet need. We found that nano-size particles were accumulated in myocarditis hearts. Then, we have developed FK506(an immunosuppressant drug) coated with nano-size liposome. In rat myocarditis model, we found that liposomal FK506 prevented the cardiac dysfunction more than FK506 did. Liposomes are promising for developing new treatments for fluminant myocarditis.

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