Research activity information

• Jan. 2019 神戸大学, 神戸大学優秀若手研究者賞

  佐藤 幸治


• Jan. 2019 公益財団法人日本スポーツ協会, 秩父宮スポーツ医・科学賞 奨励賞

  高強度, 間欠的トレーニング(HIIT)研究開発グループ


• Jul. 2014 日本運動生理学会, 若手研究奨励賞

  SATO KOJI

  Japan society


• Mar. 2013 ヤマハ発動機, 特別チャレンジャー賞

  SATO KOJI

  Publisher


• Aug. 2010 American Physiological Society, Travel Award

  Koji Sato

  International society

• Chronic intake of Dioscorea esculenta suppresses testicular atrophy, enhances the ability of protection from inflammation in type 2 diabetes rats.

  Koki Tatara, Koji Sato

  Dioscorea esculenta increases sex steroid hormones in obesity and type 2 diabetes that impairs steroidogenesis. However, the effects of chronic D. esculenta intake on testicular sex steroid hormone concentrations and testicular function especially protection from oxidative stress and inflammation is still unclear. The study assessed the effects of chronic D. esculenta intake and exercise training on testicular function in rats with type 2 diabetes. Twenty-week-old Otsuka Long-Evans Tokushima Fatty rats were randomly assigned to the control, exercise training (running at 25 m/min for 1 h, 5 days/week), and D. esculenta intake (0.3 % with normal feed) groups (n = 8 per group). Long-Evans Tokushima Otsuka rats served as the healthy controls (n = 7). Eight weeks of D. esculenta intake or exercise training significantly increased plasma concentrations of dehydroepiandrosterone (DHEA), free testosterone and 5α-dihydrotestosterone (DHT). No significant increases were observed in DHEA, testosterone, and DHT concentrations in the testis. Androgen receptor (AR) expression was significantly increased by D. esculenta intake and exercise training. The expression of cathepsin L, which is involved in sperm modification, did not significantly change, whereas the expression of glutathione peroxidase 4 (GPx4), which protects sperms from oxidative stress, significantly increased in the D. esculenta group. Additionally, metabolic clearance rate (MCR), an index of insulin resistance, significantly correlated with testicular weight and GPx4 expression. These results suggest that improvement in MCR through D. esculenta intake suppresses testicular atrophy and enhances the ability of protection from oxidative stress and inflammation in rats with type 2 diabetes.

  Mar. 2025, The Journal of Steroid Biochemistry and Molecular Biology, 250, 106730 - 106730, English, International magazine

  [Refereed]

  Scientific journal


• 月経前症候群と自律神経活動動態—Premenstrual syndrome and autonomic nervous system activity—特集 精神薬理学における自律神経機能の役割

  松本 珠希, 木村 哲也, 佐藤 幸治

  東京 : 星和書店, Feb. 2025, 臨床精神薬理 = Japanese journal of clinical psychopharmacology, 28(2) (2), 151 - 161, Japanese


• Suppression of gp130 attenuated insulin-mediated signaling and glucose uptake in skeletal muscle cells.

  Koji Sato

  The aim of the present study was to investigate the effects of Oncostatin M receptor (OSMR) subunit gp130 knockdown on insulin-stimulated glucose metabolism-related signaling pathways and glucose uptake in skeletal muscle cells. siRNA-mediated gp130 knockdown was conducted in C2C12 muscle cells, and insulin was added and incubated for 1 h. The cells were cultivated to analyze the mRNA levels of gp130, phosphorylation of STAT3, and glucose metabolism-regulated signaling pathways, and OSM levels in the culture medium were analyzed. The phosphorylation of STAT 3 was significantly decreased in gp130-/- cell. The insulin stimulation was significantly increased in both gp130-/- and gp130+/+ and the phosphorylation of IRS-1 Ser 1101 was significantly decreased in gp130-/-. PI3-kinase activity and Akt Thr 308 phosphorylation were significantly decreased in gp130-/-. The insulin-stimulated increase in glucose uptake rate was significantly attenuated in gp130-/-. In the culture medium, OSM levels were significantly lower in gp130+/+compared to gp130-/- cell. In conclusion, the knockdown of gp130 caused a decrease in STAT 3 phosphorylation and resulted in the attenuation of insulin-mediated glucose metabolism signaling in skeletal muscle cells. Thus, an excessive increase in extracellular OSM may induce blunted insulin action in skeletal muscle cells.

  Jul. 2024, Scientific Reports, 14(1) (1), 17496 - 17496, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Comparison of nutritional values for dioscorea esculenta grown in a cultivated sub-tropical region and a plastic greenhouse in a cold region

  Koji Sato, Koichi Umekage, Machiko Kumamoto

  Jun. 2024, South African Journal of Botany, 169, 1 - 5

  Scientific journal


• Altered expression of synaptic proteins and adhesion molecules in the hippocampus and cortex following the onset of diabetes in nonobese diabetic mice

  Takumi Yokokawa, Kohei Kido, Koji Sato, Tatsuya Hayashi, Satoshi Fujita

  Mounting evidence links Type 1 diabetes (T1D) with cognitive dysfunction, psychiatric disorders, and synaptic alterations; however, the underlying mechanism remains unclear. Numerous synaptic proteins and synaptic adhesion molecules (SAMs) that orchestrate synaptic formation, restructuring, and elimination are essential for proper brain function. Currently, it is unclear whether the pathogenesis of T1D is related to the expression of synaptic proteins and SAMs. Here, we investigated whether T1D mice exhibited altered synaptic protein and SAM expression in the hippocampus and cortex. We discovered that T1D mice exhibited partially decreased levels of excitatory and inhibitory synapse proteins and SAMs, such as neurexins, neuroligins, and synaptic cell adhesion molecules. We also found that compared to control mice, T1D mice showed a marginal decrease in body weight and a significant increase in plasma glycoalbumin levels (a hyperglycemia marker). These results provide novel molecular-level insights into synaptic dysfunction in mice with T1D.

  Wiley, Apr. 2023, Physiological Reports, 11(8) (8), e15673, English, International magazine

  [Refereed]

  Scientific journal


• Emotional valence of self-defining memories in older adults: A longitudinal study

  Kouhei Masumoto, Koji Sato, Kazuhiro Harada, Kenta Yamamoto, Mariko Shiozaki

  Elsevier BV, Nov. 2022, Consciousness and Cognition, 106, 103431 - 103431

  [Refereed]

  Scientific journal


• The effect of Dioscorea esculenta powder on prostaglandin E2 and cytochrome c oxidase subunit 2 levels, menstrual pain, and premenstrual syndrome in young women: A randomized double-blind controlled trial.

  Koji Sato, Kaori Seto

  Background Diosgenin, extracted from Dioscorea esculenta, has been reported to decrease prostaglandin E2 (PGE2) levels and any other inflammatory cytokine in rodents. However, it is still unclear whether D. esculenta intake suppressed PGE2 production and menstrual pain and premenstrual syndrome (PMS) in younger female. Aim This study aims to investigate the effect of D. esculenta intake on PGE2 and cytochrome c oxidase subunit 2 (COX-2) levels and on menstrual pain and PMS in young women. This is a randomized, double-blind, placebo-controlled, crossover study. Methods Ten healthy young females were administered either a placebo or D. esculenta (300 mg/day) for 4 weeks, followed by a 4-week washout period. Fasting blood sample was taken from the fingertips on the second day of menstrual cycle began and obtained 24h before the last D. esculenta to avoid acute effects. Participants then switched treatments for 4 weeks as a second trial. Plasma PGE2 and COX-2 levels were measured before and after each trial. The visual analogue scale (VAS), McGill pain questionnaire (MPQ), and Daily Record of Severity of Problems (DRSP) were also evaluated. The study was set and conducted from 2019 to 2020. Results PGE2 and COX-2 levels significantly decreased after D. esculenta intake compared to placebo (p = 0.038, p = 0.042 each). The VAS and DRSP scores were also significantly lower after D. esculenta intake (p = 0.046, p = 0.035 each). Conclusion Four-week D. esculenta intake suppressed PGE2 and COX-2 levels resulting in an improvement in PMS symptoms and menstrual pain in young women.

  Oct. 2022, Nutrition and Health, 2601060221130889 - 2601060221130889, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effects of acute aerobic exercise and menstrual cycle on immune responses in young women

  Koji Sato, Yoka Kumazawa, Tetsuya Kimura

  Dec. 2021, Gynecological and Reproductive Endocrinology & Metabolism, English

  [Refereed]

  Scientific journal


• Oral chronic sulforaphane effects on heavy resistance exercise: Implications on inflammatory and muscle damage parameters in young practitioners.

  Koji Sato, Hinata Kihara, Yoka Kumazawa, Koki Tatara

  OBJECTIVE: Sulforaphane is a phytochemical that is commonly found in broccoli and broccoli sprouts. However, whether chronic sulforaphane ingestion suppresses heavy resistance exercise-induced muscle damage parameters in humans remains unknown. Therefore, this study investigated the effects of oral chronic sulforaphane ingestion on heavy resistance exercise-induced muscle damage parameters. METHODS: The study had a randomized, double-blind, placebo-controlled, cross-over design. Ten healthy young men (age: 22.0 ± 0.3 y; body weight: 62.6 ± 2.4 kg; height: 171.0 ± 0.1 cm) were administered placebo or sulforaphane (30 mg/d) for 4 wk at the first trial, then after a 4-wk washout period, the participants were administered the opposite treatment for 4 wk at the second trial. The participants were subjected to heavy resistance exercise (bench press, 85% of one-repetition maximum for three times with eight repetitions) after each administration, and blood samples were collected before and at 30 min and 24 h after each exercise session. RESULTS: In this study, 4 wk of sulforaphane intake decreased plasma levels of creatine kinase, especially creatine kinase levels from 30 min to 24 h and baseline to 24 h. Moreover, the change in interleukin-6 levels significantly decreased from baseline to 30 min on prolonged intake of sulforaphane. CONCLUSIONS: Together, these findings suggest that the oral chronic intake of sulforaphane suppressed the heavy resistance exercise-induced increase in muscle damage parameter and expression of inflammatory cytokines. The chronic use of sulforaphane may be a novel therapeutic candidate for the prevention of muscle damage in athletes training daily with high-intensity exercise.

  Apr. 2021, Nutrition (Burbank, Los Angeles County, Calif.), 90, 111266 - 111266, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Dehydroepiandrosterone activates 5′-adenosine monophosphate-activated protein kinase and suppresses lipid accumulation and adipocyte differentiation in 3T3-L1 cells

  Takumi Yokokawa, Koji Sato, Ryoko Narusawa, Kohei Kido, Risako Mori, Nobumasa Iwanaka, Tatsuya Hayashi, Takeshi Hashimoto

  Substantial evidence has linked dehydroepiandrosterone (DHEA) levels to the anti-obesity and anti-diabetic effects of exercise. While 5'-adenosine monophosphate-activated protein kinase (AMPK) is a negative regulator of adipocyte differentiation and lipid accumulation, activation of mammalian target of rapamycin complex 1 (mTORC1), which is inhibited by AMPK, is required for adipocyte differentiation and positively regulates lipid accumulation. DHEA treatment activates the AMPK pathway in C2C12 myotubes. Hence, DHEA addition to preadipocytes and adipocytes might activate AMPK and inhibit mTORC1, resulting in the inhibition of adipogenesis and lipid accumulation. Therefore, we investigated the effect of DHEA on the AMPK pathway, mTORC1 activity, adipocyte differentiation, and lipid accumulation in 3T3-L1 cells. DHEA suppressed lipid accumulation and adipogenic marker expression during differentiation. It also activated AMPK signaling in preadipocytes and adipocytes and suppressed mTORC1 activity during differentiation. These results suggest that the activation of the AMPK pathway and inhibition of mTORC1 activity may mediate the anti-obesity effect of DHEA, providing novel molecular-level insights into its physiological functions.

  Elsevier BV, Jun. 2020, Biochemical and Biophysical Research Communications, 528(3) (3), 614 - 620, English, International magazine

  [Refereed]

  Scientific journal


• Associations among Bone Mineral Density, Physical Activity and Nutritional Intake in Middle-Aged Women with High Levels of Arterial Stiffness: A Pilot Study.

  Kanako Hamaguchi, Toshiyuki Kurihara, Masahiro Fujimoto, Koji Sato, Motoyuki Iemitsu, Takafumi Hamaoka, Kiyoshi Sanada

  There is little consensus regarding the impacts of physical activity and nutrient intake on bone mineral density (BMD) in subjects with high or low levels of arterial stiffness. This study was performed to investigate whether physical activity and nutrient intake are associated with BMD in middle-aged women with high levels of arterial stiffness. The study population consisted of middle-aged women aged 40-64 years (n = 22). BMD was assessed by dual-energy X-ray absorptiometry. Carotid-femoral pulse wave velocity (cf-PWV) was used as an indicator of arterial stiffness. Subjects were divided into two groups by median cf-PWV. Physical activity in free-living conditions was evaluated using a triaxial accelerometer. Nutrient intake was also measured using the brief-type self-administered diet history questionnaire. In the High-PWV group, BMD showed a significant negative correlation with age. Using a partial correlation model, BMD was associated with the number of steps and unsaturated fatty acid intake in the High-PWV group. These results suggest that BMD in middle-aged women with high levels of arterial stiffness may be associated with both the number of steps and nutritional intake. Recommendations of physical activity and nutritional intake for the prevention of osteopenia should include consideration of arterial stiffness.

  Mar. 2020, International journal of environmental research and public health, 17(5) (5), English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Social Interaction in Walking Groups and Affective Responses Among Japanese Older Adults.

  Kazuhiro Harada, Kouhei Masumoto, Ai Fukuzawa, Michiko Touyama, Koji Sato, Narihiko Kondo, Shuichi Okada

  This study examined whether satisfaction with social interactions and the number of people interacted with during walking groups is associated with affective responses among older adults. Twenty-six older adults were asked to participate in five walking group sessions. The participants walked together for 40-50 min. In every session, the participants reported their affective responses to walking (positive engagement, tranquility, and negative affect), their level of satisfaction with the social interactions experienced, and the number of people interacted with during the walk. The available data were from 107 person-sessions. Multilevel models revealed that, although a higher number of people interacted with was not significantly associated with improvements in any affective responses, higher satisfaction with the interactions was significantly associated with improvements in positive engagement at both the within- and between-person levels. This study found that higher satisfaction with the interactions was associated with desirable affective responses among older adults.

  Nov. 2019, Journal of aging and physical activity, 28(2) (2), 1 - 7, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Type 2 diabetes causes skeletal muscle atrophy but does not impair resistance training-mediated myonuclear accretion and muscle mass gain in rats.

  Satoru Ato, Kohei Kido, Koji Sato, Satoshi Fujita

  NEW FINDINGS: What is the central question of this study? Type 2 diabetes mellitus (T2DM) causes skeletal muscle atrophy; does it affect resistance training (RT)-mediated molecular adaptations and subsequent muscle hypertrophy? What is the main finding and its importance? Although skeletal muscle mass and regulation were not preserved under conditions of T2DM, the response of RT-induced skeletal muscle hypertrophy was not impaired in T2DM rat skeletal muscle. These findings suggest that the capacity of RT-mediated muscle mass gain is not diminished in the T2DM condition. ABSTRACT: Type 2 diabetes mellitus (T2DM) is known to cause skeletal muscle atrophy. However, it is not known whether T2DM affects resistance training (RT)-mediated molecular adaptations and subsequent muscle hypertrophy. Therefore, we investigated the effect of T2DM on response of skeletal muscle hypertrophy to chronic RT using a rat resistance exercise mimetic model. T2DM and healthy control rats were subjected to 18 bouts (3 times per week) of chronic RT on unilateral lower legs. RT significantly increased gastrocnemius muscle mass and myonuclei in both T2DM and healthy control rats to the same extent, even though T2DM caused muscle atrophy in the resting condition. Further, T2DM significantly reduced mechanistic target of rapamycin complex 1 (mTORC1) activity (phosphorylation of p70S6KThr389 and 4E-BP1Thr37/46 ) to insulin stimulation and the number of myonuclei in the untrained basal condition, but RT-mediated adaptations were not affected by T2DM. These findings suggested that although the skeletal muscle mass and regulation were not preserved under basal conditions of T2DM, the response of RT-induced skeletal muscle hypertrophy was not impaired in T2DM rat skeletal muscle.

  Oct. 2019, Experimental physiology, 104(10) (10), 1518 - 1531, English, International magazine

  [Refereed]

  Scientific journal


• 動脈硬化指標を用いて分類した中年期女性の骨密度と身体活動および栄養摂取の関係

  浜口 佳夏子, 栗原 俊之, 藤本 雅大, 佐藤 幸治, 家光 素行, 浜岡 隆文, 真田 樹義

  (一社)日本体力医学会, Apr. 2019, 体力科学, 68(2) (2), 171 - 171, Japanese


• Aerobic exercise training and dehydroepiandrosterone administration increase testicular sex steroid hormones and enhance reproductive function in high-sucrose-induced obese rats.

  Tatara K, SATO KOJI

  ELSEVIER, Apr. 2019, J Steroid Biochem Mol Biol, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The effects of resistance training on bone mineral density and bone quality in type 2 diabetic rats

  Ikedo A, Kido K, Ato S, Sato K, Woo Lee J, Fujita S, Imai Y

  Resistance training (RT) has been known to be effective in maintaining and improving bone strength, which is based on bone mineral density (BMD) and bone quality. However, it is not clear whether RT is effective in improving bone strength in patients with type-2 diabetes mellitus (T2DM), who have a high risk of fracture. Therefore, we tested the effects of a 6-week RT regimen using percutaneous electrical stimulation in T2DM model rats, male Otsuka Long-Evans Tokushima Fatty (OLETF), and its control, Long-Evans Tokushima Otsuka (LETO). After 6 weeks of RT, tibial BMD in RT legs was significantly higher than that in control (CON) legs in both groups. In diaphyseal cortical bone, bone area/tissue area, and cortical thickness was significantly increased in RT legs compared with CON legs in both groups. Cortical porosity was highly observed in OLETF compared with LETO, but RT improved cortical porosity in both groups. Interestingly, trabecular number, trabecular thickness and trabecular space as well as BMD and bone volume/tissue volume in proximal tibial metaphyseal trabecular bone were significantly improved in RT legs compared with CON legs in both groups. In contrast, connectivity density and structural model index were not affected by RT. These results indicate that the 6-week RT regimen effectively increased BMD and improved bone quality in T2DM model rats as well as control rats. Therefore, RT may have the potential to improve bone strength and reduce fracture risk, even in patients with T2DM.

  American Physiological Society, 2019, Physiological Reports, 7(6) (6), e14046, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effect of Mixed Meal and Leucine Intake on Plasma Amino Acid Concentrations in Young Men

  YoshiiN, SATO KOJI, Ogasawara R, Nishimura Y, Shinohara Y, Fujita S

  Oct. 2018, Nutrients, 10(10) (10), 1543, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 日本人中高齢女性を対象とした内臓脂肪の分布とメタボリックシンドロームリスク因子との関係

  中山侑紀, 井門あゆみ, 石井好二郎, 家光素行, 佐藤幸治, 藤本雅大, 栗原俊之, 浅原哲子, 真田樹義

  京都滋賀体育学会, Aug. 2018, 京都滋賀体育学研究, 34, 10-18 - 19, Japanese

  [Refereed]


• 肥満ラットの有酸素性トレーニングによる動脈血管の apelin産生の増加は内皮型一酸化窒素合成酵素の活性に影響する

  井上健一郎, 藤江隼平, 長谷川夏輝, 堀居直希, 内田昌孝, 佐藤幸治, 家光素行

  Jul. 2018, 京都滋賀体育学研究, 34, 20-28

  [Refereed]


• Resistance training recovers attenuated APPL1 expression and improves insulin-induced Akt signal activation in skeletal muscle of type 2 diabetic rats.

  Kido K, Ato S, Yokokawa T, SATO KOJI, Fujita S

  American Physiological Society, Feb. 2018, Am J Physiol Endocrinol Metab, English

  [Refereed]

  Scientific journal


• The Role of Dehydroepiandrosterone (DHEA) in Skeletal Muscle.

  Koji Sato, Motoyuki Iemitsu

  Dehydroepiandrosterone (DHEA) is a precursor of sex steroid hormones and is converted to testosterone and estradiol. Normally, androgens and estrogens produced adrenal cortex, testis, and ovary; however, recent studies revealed androgens and estrogens are synthesized by peripheral tissues such as brain, skin, liver, kidney, bone, etc. We found skeletal muscles are also capable of synthesizing androgens and estrogens from DHEA. Circulating DHEA provides substrates required for conversion into potent androgens and estrogens in peripheral tissues. Sex steroid hormone administration has important roles: one is that the enhancement of protein synthesis and anabolism, resulting in muscle growth and increased muscle strength. The other is improvement of hyperglycemia through the activation of glucose signaling pathway in skeletal muscle as well as acceleration of muscle lipid metabolism that increase peroxisome proliferator-activated receptor alpha (PPARα) and PPAR delta (PPARδ). We introduce the effect of DHEA and sex steroid hormones administration on muscle glucose and lipid metabolisms as well as the effect of sex steroid hormone on the muscle hypertrophy.

  Lead, 2018, Vitamins and hormones, 108, 205 - 221, English, International magazine

  [Refereed]

  Scientific journal


• 閉経後サルコペニア女性を対象とした骨密度に対する軽負荷パワートレーニング効果の個体差に関連する要因の検討

  浜口佳奈子, 栗原俊之, 藤本雅大, 家光素行, 佐藤幸治, 浜岡隆文, 真田樹義

  2018, トレーニング科学, 30(1) (1), 45 - 54

  [Refereed]


• Muscle Androgen Receptor Content but Not Systemic Hormones is Associated with Resistance Training-Induced Skeletal Muscle Hypertrophy in Healthy, Young Men

  Morton RW, Sato K, Gallaugher MPB, Oikawa SY, McNicholas PD, Fujita S, Phillips SM

  2018, Frontiers in Physiology, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effect of resistance exercise under conditions of reduced blood insulin on AMPK alpha Ser485/491 inhibitory phosphorylation and AMPK pathway activation

  Kohei Kido, Takumi Yokokawa, Satoru Ato, Koji Sato, Satoshi Fujita

  Aug. 2017, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 313(2) (2), R110 - R119, English

  [Refereed]

  Scientific journal


• Acute bout of exercise induced prolonged muscle glucose transporter-4 translocation and delayed counter-regulatory hormone response in type 1 diabetes

  Koji Sato, Takeshi Nishijima, Takumi Yokokawa, Satoshi Fujita

  Jun. 2017, PLOS ONE, 12(6) (6), English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The effects of low-repetition and light-load power training on bone mineral density in postmenopausal women with sarcopenia: a pilot study

  Kanako Hamaguchi, Toshiyuki Kurihara, Masahiro Fujimoto, Motoyuki Iemitsu, Koji Sato, Takafumi Hamaoka, Kiyoshi Sanada

  May 2017, BMC GERIATRICS, 17(1) (1), 102, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Mechanism Underlying Preventive Effect of High-Intensity Training on Colon Cancer.

  Matsuo K, Sato K, Suemoto K, Miyamoto-Mikami E, Fuku N, Higashida K, Tsuji K, Xu Y, Liu X, Iemitsu M, Tabata I

  American Colleage of Sports Medicine, May 2017, Med Sci Sports Exerc, English

  [Refereed]

  Scientific journal


• Dioscorea esculenta-induced increase in muscle sex steroid hormones is associated with enhanced insulin sensitivity in a type 2 diabetes rat model

  Koji Sato, Satoshi Fujita, Motoyuki Iemitsu

  Feb. 2017, FASEB JOURNAL, 31(2) (2), 793 - 801, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Relationship between dietary protein or essential amino acid intake and training-induced muscle hypertrophy among older individuals

  Naomi Yoshii, Koji Sato, Riki Ogasawara, Toshiyuki Kurihara, Takafumi Hamaoka, Satoshi Fujita

  Center for Academic Publications Japan, 2017, Journal of Nutritional Science and Vitaminology, 63(6) (6), 379 - 388, English

  [Refereed]

  Scientific journal


• Increased Muscular 5 alpha-Dihydrotestosterone in Response to Resistance Training Relates to Skeletal Muscle Mass and Glucose Metabolism in Type 2 Diabetic Rats

  Naoki Horii, Koji Sato, Noboru Mesaki, Motoyuki Iemitsu

  Nov. 2016, PLOS ONE, 11(11) (11), English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effects of habitual aerobic exercise on the relationship between intramyocellular or extramyocellular lipid content and arterial stiffness

  Natsuki Hasegawa, Shumpei Fujie, Toshiyuki Kurihara, Toshiyuki Homma, Kiyoshi Sanada, Koji Sato, Takafumi Hamaoka, Motoyuki. Iemitsu

  Oct. 2016, JOURNAL OF HUMAN HYPERTENSION, 30(10) (10), 606 - 612, English

  [Refereed]

  Scientific journal


• Acute Effect of Static Stretching Exercise on Arterial Stiffness in Healthy Young Adults

  Yosuke Yamato, Natsuki Hasegawa, Koji Sato, Takafumi Hamaoka, Shigehiko Ogoh, Motoyuki Iemitsu

  Oct. 2016, AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, 95(10) (10), 764 - 770, English

  [Refereed]

  Scientific journal


• Elevated pentraxin 3 level at the early stage of exercise training is associated with reduction of arterial stiffness in middle-aged and older adults

  Asako Zempo-Miyaki, Shumpei Fujie, Koji Sato, Natsuki Hasegawa, Kiyoshi Sanada, Seiji Maeda, Takafumi Hamaoka, Motoyuki Iemitsu

  Sep. 2016, JOURNAL OF HUMAN HYPERTENSION, 30(9) (9), 521 - 526, English

  [Refereed]

  Scientific journal


• Acute resistance exercise-induced IGF1 expression and subsequent GLUT4 translocation

  Kohei Kido, Satoru Ato, Takumi Yokokawa, Yuhei Makanae, Koji Sato, Satoshi Fujita

  Wiley-Blackwell Publishing Ltd, Aug. 2016, Physiological Reports, 4(16) (16), English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• DHEA Administration Activates Transcription of Muscular Lipid Metabolic Enzymes via PPAR and PPAR in Obese Rats

  Naoki Horii, Koji Sato, Noboru Mesaki, Motoyuki Iemitsu

  Mar. 2016, HORMONE AND METABOLIC RESEARCH, 48(3) (3), 207 - 212, English

  [Refereed]

  Scientific journal


• Herbal supplement Kamishimotsuto augments resistance exercise-induced mTORC1 signaling in rat skeletal muscle

  Kohei Kido, Koji Sato, Yuhei Makanae, Satoru Ato, Tadahiro Hayashi, Satoshi Fujita

  Jan. 2016, NUTRITION, 32(1) (1), 108 - 113, English

  [Refereed]

  Scientific journal


• Responses of sex steroid hormones to different intensities of exercise in endurance athletes

  Koji Sato, Motoyuki Iemitsu, Keisho Katayama, Koji Ishida, Yoji Kanao, Mitsuru Saito

  Lead, Jan. 2016, EXPERIMENTAL PHYSIOLOGY, 101(1) (1), 168 - 175, English

  [Refereed]

  Scientific journal


• 日本人女性を対象としたメタボリックシンドロームリスク因子に対する睡眠および加齢の相互関係（パイロット研究）

  梅田果林, 高垣大地, 渡邉真也, 浜口佳奈子, 古嶋大詩, 佐藤幸治, 栗原俊之, 家光素行, 浜岡隆文, 真田樹義

  Dec. 2015, 睡眠と環境, 10-11(1) (1), 5-14

  [Refereed]


• Ultrasound-Derived Abdominal Muscle Thickness Better Detects Metabolic Syndrome Risk in Obese Patients than Skeletal Muscle Index Measured by Dual-Energy X-Ray Absorptiometry

  Ayumi Ido, Yuki Nakayama, Kojiro Ishii, Motoyuki Iemitsu, Koji Sato, Masahiro Fujimoto, Toshiyuki Kurihara, Takafumi Hamaoka, Noriko Satoh-Asahara, Kiyoshi Sanada

  Dec. 2015, PLOS ONE, 10(12) (12), e0143858, English

  [Refereed]

  Scientific journal


• Intramyocellular and Extramyocellular Lipids Are Associated With Arterial Stiffness

  Natsuki Hasegawa, Toshiyuki Kurihara, Koji Sato, Toshiyuki Homma, Shumpei Fujie, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu

  Dec. 2015, AMERICAN JOURNAL OF HYPERTENSION, 28(12) (12), 1473 - 1479, English

  [Refereed]

  Scientific journal


• Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults

  Shumpei Fujie, Natsuki Hasegawa, Koji Sato, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu

  Nov. 2015, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 309(10) (10), H1642 - H1647, English

  [Refereed]

  Scientific journal


• Acute bout of resistance exercise increases vitamin D receptor protein expression in rat skeletal muscle

  Yuhei Makanae, Riki Ogasawara, Koji Sato, Yusuke Takamura, Kenji Matsutani, Kohei Kido, Naruhiro Shiozawa, Koichi Nakazato, Satoshi Fujita

  Oct. 2015, EXPERIMENTAL PHYSIOLOGY, 100(10) (10), 1168 - 1176, English

  [Refereed]

  Scientific journal


• Dehydroepiandrosterone activates AMP kinase and regulates GLUT4 and PGC-1 alpha expression in C2C12 myotubes

  Takumi Yokokawa, Koji Sato, Noburnasa Iwanaka, Hiroki Honda, Kazuhiko Higashida, Motoyuki Iemitsu, Tatsuya Hayashi, Takeshi Hashimoto

  Jul. 2015, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 463(1-2) (1-2), 42 - 47, English

  [Refereed]

  Scientific journal


• 高強度クロス運動トレーニングが糖負荷試験成績に与える影響に関する研究

  田畑 泉, 宮本 恵理, 佐藤 幸治, 街 勝憲, 徐 宇中, 家光 素行

  (一社)日本体力医学会, Apr. 2015, 体力科学, 64(2) (2), 285 - 285, Japanese


• Serum C1q as a novel biomarker of sarcopenia in older adults

  Shinya Watanabe, Koji Sato, Natsuki Hasegawa, Toshiyuki Kurihara, Kenji Matsutani, Kiyoshi Sanada, Takafumi Hamaoka, Satoshi Fujita, Motoyuki Iemitsu

  Mar. 2015, FASEB JOURNAL, 29(3) (3), 1003 - 1010, English

  [Refereed]

  Scientific journal


• Endurance Training-Induced Increase in Circulating Irisin Levels Is Associated with Reduction of Abdominal Visceral Fat in Middle-Aged and Older Adults

  Eri Miyamoto-Mikami, Koji Sato, Toshiyuki Kurihara, Natsuki Hasegawa, Shumpei Fujie, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Izumi Tabata, Motoyuki Iemitsu

  Mar. 2015, PLOS ONE, 10(3) (3), English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 高校生女子陸上競技選手における疲労骨折リスクと骨密度に関する検討

  池戸 葵, 松宮 さおり, 石橋 彩, 海崎 彩, 佐藤 幸治, 祐伯 敦史, 浜岡 隆文, 藤田 聡, 海老 久美子

  (NPO)日本スポーツ栄養学会, Jan. 2015, 日本スポーツ栄養研究誌, 8, 70 - 70, Japanese


• Interaction between Sleep Duration and Age on Metabolic Syndrome Risk Factors in Japanese Women

  Umeda K, Takagaki D, Watanabe S, Hamaguchi K, Furushima T, Sato K, Kurihara T, Iemitsu M, Hamaoka T, Sanada K

  2015, 睡眠と環境(J.Sleep and Environments)


• 日本人成人肥満男女を対象としたサルコペニア簡易評価法の開発

  古嶋大詩, 中山侑紀, 井門あゆみ, 家光素行, 栗原俊之, 本間俊行, 佐藤幸治, 藤本雅大, 浜岡隆文, 石井好二郎, 真田樹義

  2015, 肥満研究, 21(3) (3), 167 - 176


• Exercise and sex steroid hormones in skeletal muscle

  Koji Sato, Motoyuki Iemitsu

  Jan. 2015, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 145, 200 - 205, English

  [Refereed][Invited]

  Scientific journal


• Serum sex steroids and steroidogenesis-related enzyme expression in skeletal muscle during experimental weight gain in men

  K. Sato, D. Samocha-Bonet, D. J. Handelsman, S. Fujita, G. A. Wittert, L. K. Heilbronn

  Dec. 2014, DIABETES & METABOLISM, 40(6) (6), 439 - 444, English

  [Refereed]

  Scientific journal


• Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats

  Koji Sato, Satoshi Fujita, Motoyuki Iemitsu

  Sep. 2014, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 143, 152 - 159, English

  [Refereed]

  Scientific journal


• The order of concurrent endurance and resistance exercise modifies mTOR signaling and protein synthesis in rat skeletal muscle

  Riki Ogasawara, Koji Sato, Kenji Matsutani, Koichi Nakazato, Satoshi Fujita

  May 2014, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 306(10) (10), E1155 - E1162, English

  Scientific journal


• Resistance training restores muscle sex steroid hormone steroidogenesis in older men.

  Koji Sato, Motoyuki Iemitsu, Kenji Matsutani, Toshiyuki Kurihara, Takafumi Hamaoka, Satoshi Fujita

  Skeletal muscle can synthesize testosterone and 5α-dihydrotestosterone (DHT) from dehydroepiandrosterone (DHEA) via steroidogenic enzymes in vitro, but hormone levels and steroidogenic enzyme expression decline with aging. Resistance exercise has been shown to increase in plasma sex steroid hormone levels. However, it remains unclear whether resistance training can restore impaired steroidogenic enzyme expressions in older individuals. Six young and 13 older men were recruited, and muscle biopsies were taken from the vastus lateralis at basal state. The same group of older subjects underwent resistance training involving knee extension and flexion exercises for 12 wk, and post-training biopsies were performed 4-5 d after the last exercise session. Muscular sex steroid hormone levels and sex steroidgenesis-related enzyme expressions were significantly lower in older subjects than younger ones at baseline, but 12 wk of resistance training significantly restored hormone levels (DHEA: 432±26 at baseline, 682±31 pg/μg protein, DHT: 6.2±0.9 at baseline, 9.8±1.4 pg/μg protein). Furthermore, the steroidogenesis-related enzymes such as 3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD, and 5α-reductase expressions were significantly restored by resistance training. We conclude progressive resistance training restores age-related declines in sex steroidogenic enzyme and muscle sex steroid hormone levels in older men.

  Apr. 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(4) (4), 1891 - 7, English, International magazine

  [Refereed]

  Scientific journal


• Reduction of Arterial Stiffness by Exercise Training Is Associated with Increasing Plasma Apelin Level in Middle-Aged and Older Adults

  Shumpei Fujie, Koji Sato, Eri Miyamoto-Mikami, Natsuki Hasegawa, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu

  Apr. 2014, PLOS ONE, 9(4) (4), English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• マルチスライスで見た内臓脂肪面積とメタボリックシンドロームリスク及び体力との関係

  真田 樹義, 中山 侑紀, 井門 あゆみ, 栗原 俊之, 後藤 一成, 佐藤 幸治, 大塚 光雄, 藤田 聡, 家光 素行, 海老 久美子, 浜岡 隆文, 田畑 泉, 笹井 浩行, 蘇 リナ, 松尾 知明, 田中 喜代次

  The Japanese Society of Physical Fitness and Sports Medicine, 2014, 体力科学, 63(1) (1), 72 - 72, Japanese


• 持久性トレーニングによる血中Irisin濃度の変化と内臓脂肪減少量の関係

  宮本(三上) 恵里, 佐藤 幸治, 栗原 俊之, 藤江 隼平, 藤田 聡, 真田 樹義, 浜岡 隆文, 田畑 泉, 家光 素行

  The Japanese Society of Physical Fitness and Sports Medicine, 2014, 体力科学, 63(1) (1), 91 - 91, Japanese


• Resistance exercise increases active MMP and β1-Integrin protein expression in skeletal muscle

  Riki Ogasawara, Koichi Nakazato, Koji Sato, Marni D. Boppart, Satoshi Fujita

  American Physiological Society, 2014, Physiological Reports, 2(11) (11), English

  [Refereed]

  Scientific journal


• Resistance exercise improves age-related declines in muscle steroidogenesis in older men

  Koji Sato, Motoyuki Iemitsu, Kenji Matsutani, Toshiyuki Kurihara, Takafumi Hamaoka, Satoshi Fujita

  2014, FASEB JOURNAL, 28(4) (4), 1891 - 1897, English

  [Refereed]

  Scientific journal


• Ursolic acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscle

  Riki Ogasawara, Koji Sato, Kazuhiko Higashida, Koichi Nakazato, Satoshi Fujita

  Sep. 2013, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 305(6) (6), E760 - E765, English

  [Refereed]

  Scientific journal


• Exercise-inducible factors to activate lipolysis in adipocytes

  Takeshi Hashimoto, Koji Sato, Motoyuki Iemitsu

  Jul. 2013, JOURNAL OF APPLIED PHYSIOLOGY, 115(2) (2), 260 - 267, English

  [Refereed]

  Scientific journal


• 04生-30-口-31 高齢者を対象とした筋力トレーニングにおける強度の違いが筋機能および骨格筋量に及ぼす影響(04 運動生理学,一般研究発表抄録)

  松谷 健司, 佐藤 幸治, 家光 素行, 栗原 俊之, 小笠原 理紀, 藤田 聡

  社団法人日本体育学会, 2013, 日本体育学会大会予稿集, 64, 172 - 172, Japanese


• 04生-29-口-14 持久能鍛錬者と非鍛錬者の異なる運動負荷における性ホルモン濃度変化の比較(04 運動生理学,一般研究発表抄録)

  佐藤 幸治, 家光 素行, 片山 敬章, 石田 浩司, 金尾 洋治, 斉藤 満

  社団法人日本体育学会, 2013, 日本体育学会大会予稿集, 64, 165 - 165, Japanese


• 04生-30-口-30 アスリートの競技種目の特性に影響する骨格筋タンパクの探索(04 運動生理学,一般研究発表抄録)

  宮本 恵里, 佐藤 幸治, 藤田 聡, 家光 素行

  社団法人日本体育学会, 2013, 日本体育学会大会予稿集, 64, 171 - 171, Japanese


• 04生-30-口-37 体力レベルおよび加齢、性別と筋細胞内・外脂肪含有量の関係(04 運動生理学,一般研究発表抄録)

  長谷川 夏輝, 栗原 俊之, 佐藤 幸治, 藤田 聡, 真田 樹義, 家光 素行

  社団法人日本体育学会, 2013, 日本体育学会大会予稿集, 64, 174 - 174, Japanese


• 14介-30-ポ-28 中高齢女性を対象とした6週間低負荷パワートレーニングが転倒骨折リスクに及ぼす影響 : サルコペニア予防のための主観強度を抑えた運動プログラムの開発(14 介護福祉・健康づくり,一般研究発表抄録)

  濱口 佳奈子, 戸田 遥子, 大塚 光雄, 佐藤 幸治, 栗原 俊之, 家光 素行, 真田 樹義

  社団法人日本体育学会, 2013, 日本体育学会大会予稿集, 64, 416 - 416, Japanese


• 04生-30-ポ-64 レジスタンストレーニングによる筋肥大と摂取エネルギー量および摂取エネルギー量との関係(04 運動生理学,一般研究発表抄録)

  吉居 尚美, 松谷 健司, 佐藤 幸治, 小笠原 理紀, 栗原 俊之, 家光 素行, 藤田 聡

  社団法人日本体育学会, 2013, 日本体育学会大会予稿集, 64, 184 - 185, Japanese


• 性ホルモンに着目した運動と食事療法

  佐藤幸治, 家光素行

  2013, JATI EXPRESS, 34


• 骨格筋由来の性ステロイドホルモンの新たな役割

  家光素行, 佐藤幸治

  杏林書院, 2013, 体育の科学, 63(8) (8), 616-622 - 622, Japanese


• The exercise-induced improvement in hyperglycemia is mediated by DHT produced in the skeletal muscle of Zucker diabetic fatty rats

  Sato K, Fujita S, Yamauchi H, Shiroya Y, Kitamura H, Minato K, Iemitsu M

  The ability of exercise to improve hyperglycemia by enhancing glucose metabolism in the skeletal muscle of type 2 diabetic patients is well established. We reported sex steroid hormones can be locally synthesized in skeletal muscle and decrease fasting blood glucose levels in obese rats. Here, we determined whether exercise-induced production of sex steroid hormones in skeletal muscle could directly reverse hyperglycemia in the Zucker diabetic fatty rat model using osmotic mini pump. Thirty Zucker diabetic fatty rats were randomly assigned to the following groups: control, exercise, or exercise with continuous infusion of 5α-reductase inhibitor. The results indicated 6 weeks of exercise significantly reduced serum insulin and fasting glucose levels compared to control group. Dehydroepiandrosterone, 5α-dehydrotestosterone, and 5α-reductase levels were all significantly higher in skeletal muscle of the exercise group. Moreover, exercise increased glucose transporter-4 translocation with a concomitant upregulation of phosphorylated phosphoinositide 3-kinase, protein kinase B and C-ζ/λ. Furthermore, significant correlations were observed between fasting glucose and muscular DHT levels. Interestingly, the observed exercise-induced improvements in serum insulin and fasting glucose levels were all suppressed by administration of 5α-reductase inhibitor. These results indicated the exercise-induced improvements in glucose metabolism signaling and glucose levels may be directly attributed to the increased levels of sex steroid hormones within skeletal muscles.

  OMICS International, 2013, Journal of Diabetes and Metabolism, 4(1) (1), 1 - 239, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Exercise, nutrition, and aging in the regulation of muscle protein synthesis.

  Sato K, Fujita S

  Sarcopenia is the age-associated loss of skeletal muscle mass and strength that develops slowly over decades and becomes a significant factor to disability among the elderly population. Recent studies have indicated that blunted anabolic response to nutritional stimuli significantly contributes to the development of sarcopenia. In the present article, we will review recent findings on the role of nutritional intake on muscle protein metabolism in the elderly. This review will particularly focus on acute anabolic responses to amino acids and protein intake, age-associated changes in the response of muscle protein to meal intake, and the role of insulin resistance in muscle protein metabolism. The relationship between age-associated decline of sex steroid hormones and muscle anabolism will also be discussed in addition to the benefits of resistance exercise in muscle protein anabolism. Additionally, recent evidence on the time-course of anabolic response, molecular regulation of muscle protein synthesis, and long-term training effects will be discussed. Finally, recent evidence on the cumulative effect of resistance exercise in combination with nutritional supplementation on muscle protein metabolism will be discussed to propose possible preventative measures against sarcopenia.

  The Japanese Society of Physical Fitness and Sports Medicine, 2013, TheJournal of Physical Fitness and Sports Medicine., 2(3) (3), 295 - 300, English


• Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults

  Takashi Kawamura, Takeshi Okubo, Koji Sato, Satoshi Fujita, Kazushige Goto, Takafumi Hamaoka, Motoyuki Iemitsu

  Nov. 2012, NUTRITION, 28(11-12) (11-12), 1122 - 1126, English

  [Refereed]

  Scientific journal


• DHEA administration and exercise training improves insulin resistance in obese rats

  Koji Sato, Motoyuki Iemitsu, Katsuji Aizawa, Noboru Mesaki, Ryuichi Ajisaka, Satoshi Fujita

  May 2012, NUTRITION & METABOLISM, 9, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 04生-23-口-15 ヒト骨格筋に性ステロイドホルモン合成酵素が発現する加齢による影響(運動生理学,口頭発表,一般研究発表抄録)

  佐藤 幸治, 家光 素行, 藤田 聡

  社団法人日本体育学会, 2012, 日本体育学会大会予稿集, 63, 145 - 145, Japanese


• ２型糖尿病患者におけるレジスタンス運動の効果.

  佐藤幸治, 藤田聡

  2012, JATI EXPRESS, 29


• Increased muscular dehydroepiandrosterone levels are associated with improved hyperglycemia in obese rats

  Koji Sato, Motoyuki Iemitsu, Katsuji Aizawa, Noboru Mesaki, Satoshi Fujita

  Aug. 2011, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 301(2) (2), E274 - E280, English

  [Refereed]

  Scientific journal


• DHEA Administration Activates Local Bioactive Androgen Metabolism in Cancellous Site of Tibia of Ovariectomized Rats

  Jong-Hoon Park, Katsuji Aizawa, Motoyuki Iemitsu, Koji Sato, Takayuki Akimoto, Umon Agata, Seiji Maeda, Ikuko Ezawa, Naomi Omi

  Aug. 2011, CALCIFIED TISSUE INTERNATIONAL, 89(2) (2), 105 - 110, English

  [Refereed]

  Scientific journal


• The effect of acute exercise in water on arterial stiffness. -The difference from that of exercise on land

  Junko Nogami, Yoko Saito, Yuko Tanimura, Koji Sato, Takeshi Otuki, Seiji Maeda, Ryuichi Ajisaka

  Japanese Society of Physical Fitness and Sports Medicine, 2011, Japanese Journal of Physical Fitness and Sports Medicine, 60(3) (3), 269 - 277, Japanese

  [Refereed]

  Scientific journal


• Acute exercise activates local bioactive androgen metabolism in skeletal muscle

  Katsuji Aizawa, Motoyuki Iemitsu, Seiji Maeda, Takeshi Otsuki, Koji Sato, Takashi Ushida, Noboru Mesaki, Takayuki Akimoto

  Mar. 2010, STEROIDS, 75(3) (3), 219 - 223, English

  [Refereed]

  Scientific journal


• 中高齢男性における性ホルモンと動脈スティフネスの関係に運動習慣が及ぼす影響

  成戸 丈紘, 谷村 祐子, 野上 佳恵, 佐藤 幸治, 野上 順子, 前田 清司, 鰺坂 隆一

  (一社)日本体力医学会, Dec. 2009, 体力科学, 58(6) (6), 780 - 780, Japanese


• DHEA improves impaired activation of Akt and PKC zeta/lambda-GLUT4 pathway in skeletal muscle and improves hyperglycaemia in streptozotocin-induced diabetes rats

  K. Sato, M. Iemitsu, K. Aizawa, R. Ajisaka

  Nov. 2009, ACTA PHYSIOLOGICA, 197(3) (3), 217 - 225, English

  [Refereed]

  Scientific journal


• Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle

  Koji Sato, Motoyuki Iemitsu, Katsuji Aizawa, Ryuichi Ajisaka

  May 2008, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 294(5) (5), E961 - E968, English

  [Refereed]

  Scientific journal

• 2型糖尿病モデルラットに対する長期的なレジスタンス運動が骨組織に与える効果

  池戸 葵, 木戸 康平, 阿藤 聡, 佐藤 幸治, 今井 祐記, 藤田 聡

  (一社)日本骨代謝学会, Jul. 2017, 日本骨代謝学会学術集会プログラム抄録集, 35回, 160 - 160, Japanese


• Chronic Resistance Training-Induced Increase in Insulin-Stimulated Akt Activation and GLUT4 Translocation Is Associated with APPL1 Expression in Skeletal Muscle of Type 2 Diabetic Rat

  Kohei Kido, Satoru Ato, Yusuke Nishimura, Takumi Yokokawa, Koji Sato, Satoshi Fujita

  Jun. 2017, DIABETES, 66, A191 - A191, English

  Summary international conference


• To Reveal the Mechanism of Exercise-Induced Delayed Onset of Hypoglycemia in Type 1 Diabetes : For Development of New Exercise Guideline in Type 1 Diabetes Patients

  佐藤 幸治, 藤田 聡

  石本記念デサントスポーツ科学振興財団事務局, May 2017, デサントスポーツ科学, 38, 28 - 34, Japanese


• A New Method to Increase in Sex Steroids Hormone in Old Aged Men, Focusing on BUDO

  蒔苗 裕平, 佐藤 幸治, 藤田 聡

  石本記念デサントスポーツ科学振興財団事務局, May 2017, デサントスポーツ科学, 38, 245 - 251, Japanese


• Resistance Exercise-induced mTORC1-signal Activation Is Not Impaired in Skeletal-muscle of STZ-induced Type 1 Diabetic Rats

  Kohei Kido, Satoru Ato, Takumi Yokokawa, Tatsuki Miyake, Koji Sato, Satoshi Fujita

  May 2016, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 48(5) (5), 582 - 582, English

  Summary international conference


• Serum Adropin Level Is Associated With Arterial Stiffness And Cardiorespiratory Fitness In Older Adults

  Shumpei Fujie, Natsuki Hasegawa, Koji Sato, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu

  May 2016, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 48(5) (5), 192 - 192, English

  Summary international conference


• 単回レジスタンス運動に伴うAMPKのリン酸化及びGLUT4のトランスロケーションは一型糖尿病モデルラットの骨格筋で減弱しない

  木戸 康平, 横川 拓海, 阿藤 聡, 三宅 龍樹, 佐藤 幸治, 藤田 聡

  (一社)日本糖尿病学会, Apr. 2016, 糖尿病, 59(Suppl.1) (Suppl.1), S - 482, Japanese


• レジスタンス運動はGLUT4のトランスロケーションをより長時間促進する 有酸素性運動との比較

  木戸 康平, 阿藤 聡, 蒔苗 裕平, 佐藤 幸治, 三宅 龍樹, 藤田 聡

  (一社)日本体力医学会, Dec. 2015, 体力科学, 64(6) (6), 602 - 602, Japanese


• In vivo骨格筋最大収縮に伴う細胞内糖取り込み制御因子の応答

  木戸 康平, 阿藤 聡, 横川 拓海, 蒔苗 裕平, 佐藤 幸治, 藤田 聡

  (公社)日本生化学会, Dec. 2015, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [2LBA097] - [2LBA097], Japanese


• 3T3-L1細胞において、dehydroepiandrosteroneはAMPキナーゼの活性化を介して脂肪細胞分化を抑制する

  横川 拓海, 佐藤 幸治, 成澤 諒子, 木戸 康平, 森 理紗子, 岩中 伸壮, 林 達也, 橋本 健志

  (公社)日本生化学会, Dec. 2015, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [2LBA083] - [2LBA083], English


• 局所的なストレッチ運動が動脈スティフネスに及ぼす影響

  大和洋輔, 大和洋輔, 長谷川夏輝, 佐藤幸治, 小河繁彦, 家光素行

  (一社)日本体力医学会, 01 Dec. 2015, 体力科学, 64(6) (6), 583 - 583, Japanese


• Serum Adropin Level is Associated With Exercise Training-induced Improvement of Arterial Stiffness in Obese Adults

  Shumpei Fujie, Koji Sato, Natsuki Hasegawa, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu

  Nov. 2015, CIRCULATION, 132, English

  Summary international conference


• Analysis of the Global Gene Expression Profile Associated with Training-Induced Improvements in Anaerobic Capacity

  宮本 恵里, 家光 素行, 佐藤 幸治

  石本記念デサントスポーツ科学振興財団事務局, Jun. 2015, デサントスポーツ科学, 36, 106 - 114, Japanese


• Delayed Onset of Hypoglycemia after an Acute Bout of Exercise Is Associated with Prolonged Muscle GLUT-4 Translocation in Type 1 Diabetes

  Koji Sato, Takeshi Nishijima, Takumi Yokokawa, Satoshi Fujita

  Jun. 2015, DIABETES, 64, A200 - A200, English

  Summary international conference


• Resistance Training-Induced Muscle Hypertrophy is Associated with Compliment C1q Concentration in Elderly Men

  Shinya Watanabe, Koji Sato, Natsuki Hasegawa, Satoshi Fujita, Kiyoshi Sanada, Toshiyuki Kurihara, Takafumi Hamaoka, Motoyuki Iemitsu

  May 2015, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 47(5) (5), 94 - 94, English

  Summary international conference


• Resistance Exercise-induced Reactive Oxygen Species In Rat Skeletal Muscle Activates Mtorc1 Via Erk1/2 Signaling

  Yuhei Makanae, Riki Ogasawara, Koji Sato, Kenji Matsutani, Naruhiro Shiozawa, Koichi Nakazato, Satoshi Fujita

  May 2015, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 47(5) (5), 93 - 93, English

  Summary international conference


• Serum CTRP9 Level Is Associated With Arterial Stiffness And Cardiorespiratory Fitness

  Natsuki Hasegawa, Koji Sato, Shumpei Fujie, Shinya Watanabe, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu

  May 2015, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 47(5) (5), 742 - 742, English

  Summary international conference


• The Effect of Age and Resistance Training on alpha 7 beta 1 Integrin Expression and Activation in Human Skeletal Muscle

  Riki Ogasawara, Koji Sato, Kenji Matsutani, Takafumi Hamaoka, Marni Boppart, Satoshi Fujita

  May 2015, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 47(5) (5), 408 - 408, English

  Summary international conference


• DHEA Administration Upregulates Muscular Lipid Metabolism With PPAR-alpha And -delta Activation In Obese Rats

  Naoki Horii, Koji Sato, Motoyuki Iemitsu

  May 2015, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 47(5) (5), 487 - 487, English

  Summary international conference


• 中高齢男女を対象とした生活活動とメタボリックシンドロームリスクとの関係

  奥松功基, 青木政美, 渡邉真也, 家光素行, 佐藤幸治, 栗原俊之, 大塚光雄, 藤田聡, 浜岡隆文, 真田樹義

  2015, 京都滋賀体育学研究, 31, 11 - 16


• Musclular Lipid is Associated With a Risk Factor of Arterial Stiffness

  Natsuki Hasegawa, Toshiyuki Kurihara, Koji Sato, Satoshi Fujita, Kiyoshi Sanada, Mitsuo Otsuka, Takafumi Hamaoka, Motoyuki Lemitsu

  Nov. 2014, CIRCULATION, 130, English

  Summary international conference


• Plasma Apelin Level Contributes Exercise Training-induced Improvement of Arterial Stiffness in the Middle and Older Adults

  Shumpei Fujie, Koji Sato, Natsuki Hasegawa, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu

  Nov. 2014, CIRCULATION, 130, English

  Summary international conference


• Association between Exercise Training-induced Irisin Secretion and Reduction of Visceral Fat

  家光 素行, 佐藤 幸治, 栗原 俊之

  石本記念デサントスポーツ科学振興財団事務局, Jun. 2014, デサントスポーツ科学, 35, 113 - 122, Japanese


• Effects Of The Menstrual Cycle On The Metabolomic Profiles During Endurance Exercise In Female Athletes

  Mikako Sakamaki-Sunaga, Kayoko Kamemoto, Asako Maruyama, Aki Nakamura, Koji Sato, Satoshi Fujita

  May 2014, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 46(5) (5), 629 - 629, English

  Summary international conference


• Effects Of Cardiorespiratory Fitness Level, Age, And Sex On Intramyocellular And Extramyocellular Lipid Contents

  Natsuki Hasegawa, Toshiyuki Kurihara, Shinya Watanabe, Koji Sato, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu

  May 2014, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 46(5) (5), 458 - 458, English

  Summary international conference


• DHEA Administration-induced Increase In Adiponectin Secretion Is Associated With Muscular PPAR-alpha Expression In Obese Rats

  Naoki Horii, Koji Sato, Motoyuki Iemitsu

  May 2014, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 46(5) (5), 635 - 635, English

  Summary international conference


• Exercise Order of Concurrent Endurance and Resistance Exercise Modifies mTOR Signaling in Rat Skeletal Muscle

  Riki Ogasawara, Koji Sato, Kenji Matsutani, Koichi Nakazato, Satoshi Fujita

  May 2014, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 46(5) (5), 34 - 34, English

  Summary international conference


• Relationships Among Visceral Adipose Tissue Area Observed In The Multiple-slice, Metabolic Syndrome Risks And Cardiorespiratory Fitness

  Yuki Nakayama, Ayumi Ido, Toshiyuki Kurihara, Koji Sato, Mitsuo Otsuka, Motoyuki Iemitsu, Takafumi Hamaoka, Kiyoshi Sanada

  May 2014, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 46(5) (5), 151 - 151, English

  Summary international conference


• Dioscorea-induced Increase Of Sex Steroid Hormone Improve Hyperglycemia In Type 2 Diabetic Rats

  Koji Sato, Satoshi Fujita, Motoyuki Iemitsu

  May 2014, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 46(5) (5), 481 - 481, English

  Summary international conference


• Antioxidant Inhibits Resistance Exercise Induced Phosphorylation Of P70s6k In Rats

  Yuhei Makanae, Riki Ogasawara, Koji Sato, Kenji Matsutani, Koichi Nakazato, Naruhiro Shiozawa, Satoshi Fujita

  May 2014, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 46(5) (5), 731 - 731, English

  Summary international conference


• Reduction of Arterial Stiffness by Exercise Training Is Associated with Increasing Plasma Apelin Level

  Shumpei Fujie, Koji Sato, Eri Miyamoto-Mikami, Natsuki Hasegawa, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu

  May 2014, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 46(5) (5), 325 - 325, English

  Summary international conference


• Ageing-induced Reduction In Muscle Cross-sectional Area Is Associated With Serum C1q Concentration

  Shinya Watanabe, Koji Sato, Satoshi Fujita, Natsuki Hasegawa, Shumpei Fujie, Kiyoshi Sanada, Toshiyuki Kurihara, Takafumi Hamaoka, Motoyuki Iemitsu

  May 2014, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 46(5) (5), 587 - 587, English

  Summary international conference


• 一過性の有酸素性運動がラット骨格筋内のATF4およびアミノ酸トランスポーターに及ぼす影響

  松谷 健司, 小笠原 理紀, 佐藤 幸治, 蒔苗 裕平, 阿藤 聡, 吉居 尚美, 藤田 聡

  (公社)日本栄養・食糧学会, Apr. 2014, 日本栄養・食糧学会大会講演要旨集, 68回, 223 - 223, Japanese


• レジスタンス運動と有酸素性運動の実施順が筋タンパク質同化応答を決定する

  小笠原 理紀, 佐藤 幸治, 松谷 健司, 中里 浩一, 藤田 聡

  (一社)日本体力医学会, Feb. 2014, 体力科学, 63(1) (1), 146 - 146, Japanese


• 月経周期が女性アスリートの持久性運動時の血中代謝物質に与える影響

  須永 美歌子[坂牧], 丸山 麻子, 亀本 佳世子, 中村 亜紀, 佐藤 幸治, 藤田 聡

  (一社)日本体力医学会, Dec. 2013, 体力科学, 62(6) (6), 628 - 628, Japanese


• レジスタンス運動後のロイシン高配合必須アミノ酸混合物の摂取はAkt/PRAS40シグナル経路を介してmTORC1を活性化させる

  阿藤 聡, 小笠原 理紀, 佐藤 幸治, 松谷 健司, 家光 素行, 田中 賢治, 平林 由理, 小林 久峰, 浜岡 隆文, 藤田 聡

  (一社)日本体力医学会, Dec. 2013, 体力科学, 62(6) (6), 505 - 505, Japanese


• Continuous resistance training alters exercise-induced MMPs activation and expression of ECM components

  Riki Ogasawara, Koichi Nakazato, Koji Sato, Marni Boppart, Satoshi Fujita

  Apr. 2013, FASEB JOURNAL, 27, English

  Summary international conference


• ウルソール酸はレジスタンス運動後のラット骨格筋Aktリン酸化を亢進させる

  小笠原 理紀, 佐藤 幸治, 東田 一彦, 中里 浩一, 藤田 聡

  (公社)日本栄養・食糧学会, Apr. 2013, 日本栄養・食糧学会大会講演要旨集, 67回, 162 - 162, Japanese


• Regulation of Hypertrophic Signaling Pathways to a Low-volume Resistance Exercise in Older Individuals

  Koji Sato, Motoyuki Iemitsu, Kenji Matsutani, Takafumi Hamaoka, Toshiyuki Kurihara, Hisashi Naito, Satoshi Fujita

  Jul. 2012, JOURNAL OF GENERAL INTERNAL MEDICINE, 27, 412 - 412, English

  Summary international conference


• Differential Effect of Aging on Acute Hormonal Response to Low-Volume Resistance Exercise

  Kenji Matsutani, Koji Sato, Motoyuki Iemitsu, Takafumi Hamaoka, Kiyoshi Sanada, Toshiyuki Kurihara, Tetsuya Kimura, Tadao Isaka, Satoshi Fujita

  Jul. 2012, JOURNAL OF GENERAL INTERNAL MEDICINE, 27, 299 - 299, English

  Summary international conference


• Low-Intensity Resistance Training Using an Elastic Band Improves Muscle Mass and Function in Older People

  Kenji Matsutani, Koji Sato, Motoyuki Iemitsu, Toshiyuki Kurihara, Tetsuya Kimura, Tadao Isaka, Takafumi Hamaoka, Satoshi Fujita

  May 2012, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 44, 902 - 902, English

  Summary international conference


• Exercise Training-induced Improvement Of Impaired Muscle Glucose Metabolism Is Associated With Muscular Sex Steroid Hormone Level In Zucker Fatty Diabetes Rats

  Koji Sato, Kumiko Minato, Satoshi Fujita, Hideki Yamauchi, Noboru Mesaki, Motoyuki Iemitsu

  May 2012, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 44, 420 - 420, English

  Summary international conference


• 一過性レジスタンス運動時の筋タンパク質合成関連シグナル経路調節‐加齢の影響

  佐藤幸治, 家光素行, 松谷健司, 浜岡隆文, 栗原俊之, 内藤久士, 藤田聡

  01 Dec. 2011, 体力科学, 60(6) (6), 625, Japanese


• 骨粗鬆症モデルラットにおけるDHEA投与は海綿骨主体の脛骨近位部における性ホルモン関連合成酵素を活性化させる

  朴 鐘薫, 相澤 勝治, 家光 素行, 秋本 崇之, 佐藤 幸治, 縣 右門, 前田 清司, 江澤 郁子, 麻見 直美

  ライフサイエンス出版(株), Nov. 2011, Osteoporosis Japan, 19(Suppl.1) (Suppl.1), 300 - 300, Japanese


• Regulation of Hypertrophic Signaling Pathways to a Low-volume Resistance Exercise in Older Individuals

  Koji Sato, Motoyuki Iemitsu, Kenji Matsutani, Takafumi Hamaoka, Toshiyuki Kurihara, Hisashi Naito, Satoshi Fujita

  May 2011, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 43(5) (5), 412 - 412, English

  Summary international conference


• Differential Effect of Aging on Acute Hormonal Response to Low-Volume Resistance Exercise

  Kenji Matsutani, Koji Sato, Motoyuki Iemitsu, Takafumi Hamaoka, Kiyoshi Sanada, Toshiyuki Kurihara, Tetsuya Kimura, Tadao Isaka, Satoshi Fujita

  May 2011, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 43(5) (5), 299 - 299, English

  Summary international conference


• Aerobic Exercise Capacity and Muscle Volume After Lower Limb Suspension with Exercise Countermeasure

  Koji Sato, Keisho Katayama, Norio Hotta, Koji Ishida, Hiroshi Akima

  Dec. 2010, AVIATION SPACE AND ENVIRONMENTAL MEDICINE, 81(12) (12), 1085 - 1091, English

  [Refereed]

  Report scientific journal


• 骨粗鬆症モデルラットにおけるDHEA投与は海綿骨主体の脛骨近位部におけるアンドロゲン関連合成酵素を活性化させる

  朴 鐘薫, 相澤 勝治, 家光 素行, 秋本 崇之, 佐藤 幸治, 江澤 郁子, 麻見 直美

  (一社)日本骨代謝学会, Jul. 2010, 日本骨代謝学会学術集会プログラム抄録集, 28回, 251 - 251, Japanese


• Cycle Ergometer Exercise to Counteract Muscle Atrophy During Unilateral Lower Limb Suspension

  Hiroshi Akima, Norio Hotta, Koji Sato, Koji Ishida, Teruhiko Koike, Keisho Katayama

  Jul. 2009, AVIATION SPACE AND ENVIRONMENTAL MEDICINE, 80(7) (7), 652 - 656, English

  [Refereed]

  Report scientific journal


• 264. 肥満型高血糖モデルラットのインスリン抵抗性に対するDHEA摂取および運動療法の単独・併用効果(代謝,一般口演,第63回日本体力医学会大会)

  佐藤 幸治, 家光 素行, 相澤 勝治, 鰺坂 隆一

  日本体力医学会, 01 Dec. 2008, 体力科學, 57(6) (6), 764 - 764, Japanese


• 144. 温浴が高齢者の左室収縮・拡張機能に及ぼす影響(呼吸・循環,一般口演,第63回日本体力医学会大会)

  野上 佳恵, 野上 順子, 佐藤 幸治, 谷村 祐子, 鯵坂 隆一

  日本体力医学会, 01 Dec. 2008, 体力科學, 57(6) (6), 704 - 704, Japanese


• 一過性運動における骨格筋局所のアンドロゲン代謝活性の変動と性差

  相澤 勝治, 家光 素行, 前田 清司, 佐藤 幸治, 大槻 毅, 牛田 多加志, 目崎 登, 秋本 崇之

  (一社)日本体力医学会, Dec. 2008, 体力科学, 57(6) (6), 657 - 657, Japanese


• Relationship between left ventricular diastolic function and aerobic exercise capacity in elderly men

  Nogami Yoshie, Seo Yoshihiro, Ishizu Tomoko, Nogami Junko, Sato Koji, Tanimura Yuko, Ajisaka Ryuichi

  Jul. 2008, JOURNAL OF AGING AND PHYSICAL ACTIVITY, 16, S100 - S101

  [Refereed]


• 202. 男性ホルモンは骨格筋の糖代謝の調節に影響する(代謝,第62回日本体力医学会大会)

  佐藤 幸治, 家光 素行, 相澤 勝治, 鰺坂 隆一

  日本体力医学会, 01 Dec. 2007, 体力科學, 56(6) (6), 679 - 679, Japanese


• 128. 一過性の水中運動と陸上運動が大動脈スティフネスに及ぼす影響(呼吸・循環,第62回日本体力医学会大会)

  野上 順子, 斉藤 陽子, 谷村 祐子, 野上 佳恵, 佐藤 幸治, 家光 素行, 大槻 毅, 前田 清司, 鯵坂 隆一

  日本体力医学会, 01 Dec. 2007, 体力科學, 56(6) (6), 642 - 642, Japanese


• Ventilatory and circulatory responses at the onset of dominant and non-dominant limb exercise

  Norio Hotta, Kaoru Yamamoto, Koji Sato, Keisho Katayama, Yoshiyuki Fukuoka, Koji Ishida

  Oct. 2007, EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 101(3) (3), 347 - 358, English

  [Refereed]

  Report scientific journal


• Ventilatory and circulatory responses at the onset of exercise after eccentric exercise

  Norio Hotta, Koji Sato, Zhihu Sun, Keisho Katayama, Hiroshi Akima, Takaharu Kondo, Koji Ishida

  Jul. 2006, EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 97(5) (5), 598 - 606, English

  [Refereed]

  Report scientific journal

• Vitamins & Hormones: The Role of Dehydroepiandrosterone (DHEA) in Skeletal Muscle

  SATO KOJI, Iemitsu M

  Others, ELSEVIER, May 2018, English

  Scholarly book


• 骨格筋由来の性ステロイドホルモンの新たな役割

  家光 素行, SATO KOJI

  Others, 体育の科学, 2013, Japanese

  Scholarly book


• Exercise, nutrition, and aging in the regulation of muscle protein synthesis

  SATO KOJI, Fujita S

  Others, Journal of Physical Fitness and Sports Medicine, 2013, English

  Scholarly book


• DHEA (dehydroepiandrosterone) in Human Health and Aging. Chapter B: Prevention of Disease by DHEA, DHEA and glucose metabolism in skeletal muscle.

  Sato K, Ajisaka R

  Taylor & Francis Group LLC., 2011

• 運動・栄養による中高齢者の肥満・糖尿病予防に向けた基礎的研究

  佐藤 幸治

  京都滋賀体育学会第153回大会, Mar. 2024

  [Invited]

  Nominated symposium


• 1型糖尿病患者における運動による遅発性低血糖発症機序と予防に向けた栄養介入

  佐藤 幸治

  日本スポーツ栄養学会 第9回大会, Sep. 2023, Japanese

  [Invited]

  Nominated symposium


• 1型糖尿病における中強度運動による遅発性低血糖の発症機序

  佐藤 幸治

  第77回日本体力医学会, Sep. 2022, Japanese

  Oral presentation


• 肥満を基盤とする代謝性疾患予防に向けた新たな 運動療法・栄養介入の可能性

  第41回日本肥満学会・第38回日本肥満症治療学会, Mar. 2021, Japanese

  [Invited]

  Nominated symposium


• The effects of exercise habits and sex on immune response in different exercise intensities

  KUMAZAWA YOKA, SATO KOJI

  24th Annual Congress of the European College of Sports Science, Jul. 2019, English, Prague, International conference

  Poster presentation


• Aerobic exercise training and Dehydroepiandrosterone administration increase testicular sex steroid hormones and enhance reproductive function in obese rats

  Tatara Koki, SATO KOJI

  24th Annual Congress of the European College of Sports Science, Jul. 2019, English, Prague, International conference

  Poster presentation


• Ⅰ型糖尿病に対して骨格筋糖代謝調節経路に着目した新規運動ガイドラインの開発

  SATO KOJI

  日本運動免疫研究会 スプリングセミナー, Mar. 2019, Japanese, 流通科学大学, Domestic conference

  Public discourse


• 動脈硬化指標を用いて分類した中年期女性の骨密度と身体活動および栄養摂取の関係

  浜口 佳奈子, 栗原 俊之, 藤本 雅大, SATO KOJI, 家光 素行, 浜岡 隆文, 真田 樹義

  第33回日本体力医学会 近畿地方会, Feb. 2019, Japanese, 立命館大学 滋賀, Domestic conference

  Poster presentation


• ホームベーカリーによる高 β-glucan 大麦 40％含有食パンの調製と官能評価

  Susumu Washizuka, Reiko Okuda, Koji Sato, Naoko Kataoka-Shirasugi

  日本調理科学会平成30年度大会, Aug. 2018, Japanese, 武庫川女子大学, Domestic conference

  Oral presentation


• Resistance Training-Induced Muscle Hypertrophy is Related to Androgen Receptor Content not Intramuscular or Systemic Hormones

  Robert W Morton, SATO KOJI, Michael P.B Gallaugher, Sara Y Oikawa, Paul D McNicholas, Satoshi Fujita, Stuart M Phillips

  65th American College of Sports Medicine, May 2018, English, Minneapolis, MN, USA, International conference

  Poster presentation


• 閉経後プレサルコペニア女性を対象とした軽負荷低反復パワートレーニングにおける骨密度変化率と脈波伝搬速度の関係

  浜口 佳奈子, 栗原 俊之, 藤本 雅大, 家光 素行, SATO KOJI, 浜岡 隆文, 真田 樹義

  第72回日本体力医学会, Sep. 2017, Japanese, 愛媛県松山市（松山大学）, Domestic conference

  Poster presentation


• ラットにおける高強度短時間水泳トレーニングがepitrochlearis筋中及び血中SPARC濃度に及ぼす影響

  SATO KOJI, 街 勝憲, 徐 宇中, 田畑 泉

  第72回日本体力医学会, Sep. 2017, Japanese, 愛媛県松山市（松山大学）, Domestic conference

  [Invited]

  Nominated symposium


• アスリートのトゲドコロ摂取がレジスタンストレーニングによる 筋量・筋力に及ぼす影響

  堀居 直希, SATO KOJI, 家光 素行

  日本スポーツ栄養学会 第４回大会, Aug. 2017, Japanese, 大妻女子大学, Domestic conference

  Oral presentation


• Reduced blood insulin stimulates resistance exercise-induced AMPK pathway activation concomitant with AMPK alpha Ser 485/491 inhibitory phosphorylation in rat skeletal muscle

  Kohei Kido, Takumi Yokokawa, Satoru Ato, Koji Sato, Satoshi Fujita

  Cell Symposia, Exercise Metabolism, May 2017, English, Sweden, International conference

  Poster presentation


• The effect of chronic resistance trainingon myonuclear abundance in OLETF rat skeletal muscle

  Satoru Ato, Kohei Kido, SATO KOJI, Satoshi Fujita

  The Integrative Biology of Exercise VII, Nov. 2016, English, Phoenix, Arizona, USA, International conference

  Poster presentation


• Resistance training improves insulin-stimulated Akt activation, related to APPL1 expression in type 2 diabetic rat skeletal muscle

  Kohei Kido, Satoru Ato, Yusuke Nishimura, Tatsuki Miyake, SATO KOJI, Satoshi Fujita

  The Integrative Biology of Exercise VII, Nov. 2016, English, Phoenix, Arizona, USA, International conference

  Poster presentation


• ２型糖尿病ラットの有酸素性トレーニングによる動脈硬化の改善に動脈血管のadropin産生の増大が影響する

  藤江 隼平, 長谷川 夏輝, 堀居 直希, SATO KOJI, 家光 素行

  第71回日本体力医学会, Sep. 2016, Japanese, 岩手, Domestic conference

  Oral presentation


• 高齢期における運動トレーニングが筋局所の性ホルモン産生経路に及ぼす影響

  相澤 勝治, 家光 素行, SATO KOJI, 秋本 崇之, 目崎 登

  第71回日本体力医学会, Sep. 2016, Japanese, 岩手, Domestic conference

  Oral presentation


• インスリン分泌欠乏は筋収縮性のAMPK-Thr172のリン酸化を高める

  木戸 康平, 横川 拓海, 阿藤 聡, SATO KOJI, 藤田 聡

  第71回日本体力医学会, Sep. 2016, Japanese, 岩手, Domestic conference

  Oral presentation


• 中高齢者の動脈硬化改善に必要な有酸素性トレーニング期間と血管拡張物質産生に関する経時的検討

  藤江 隼平, 長谷川 夏輝, SATO KOJI, 真田 樹義, 浜岡 隆文, 家光 素行

  第16回抗加齢医学会大会, Jun. 2016, Japanese, 横浜, Domestic conference

  Oral presentation


• Serum Adropin Level Is Associated With Arterial Stiffness And Cardiorespiratory Fitness In Older Adults

  Shumpei Fujie, Natsuki Hasegawa, SATO KOJI, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu

  63th Annual Meeting, American College of Sports Medicine, Jun. 2016, English, Boston, USA, International conference

  Poster presentation


• Resistance Exercise-induced mTORC1-signal Activation Is Not Impaired in Skeletal-muscle of STZ-induced Type 1 Diabetic Rats

  Kohei Kido, Satoru Ato, Takumi Yokokawa, Tatsuki Miyake, SATO KOJI, Satoshi Fujita

  63th Annual Meeting, American College of Sports Medicine, Jun. 2016, English, Boston, USA, International conference

  Poster presentation


• Muscular Sex Steroid Hormone Contributes To Resistance Training-induced Skeletal Muscle Hypertrophy In Obese Rats

  Naoki Horii, SATO KOJI, Motoyuki Iemitsu

  63th Annual Meeting, American College of Sports Medicine, Jun. 2016, English, Boston, USA, International conference

  Oral presentation


• 肥満モデルラットのDHEA長期摂取は動脈組織のapelin産生増大を介してnitric oxide産生調節に影響する

  藤江 隼平, SATO KOJI, 家光 素行

  第70回日本栄養・食糧学会大会, May 2016, Japanese, 武庫川女子大学, Domestic conference

  Oral presentation


• 長期的なクロレラ摂取は無酸素性運動能力と骨格筋の解糖系を亢進させる

  堀居 直希, 長谷川 夏輝, 藤江 隼平, 溝口 亨, 大西 真人, 佐藤 幸治, 田畑 泉, 家光 素行

  第70回日本栄養・食糧学会大会, May 2016, Japanese, 武庫川女子大学, Domestic conference

  Oral presentation


• 中高齢者のトゲドコロ長期摂取による動脈硬化度への影響

  長谷川 夏輝, 藤江 隼平, 堀居 直希, SATO KOJI, 家光 素行

  第70回日本栄養・食糧学会大会, May 2016, Japanese, 武庫川女子大学, Domestic conference

  Oral presentation


• 単回レジスタンス運動の伴うAMPKのリン酸化及びGLUT4のトランスロケーションは一型糖尿病モデルラットの骨格筋で減弱しない

  木戸 康平, 阿藤 聡, 横川 拓海, SATO KOJI, 藤田 聡

  第59回日本糖尿病学会年次学術集会, May 2016, Japanese, 国立京都国際会館、みやこめっせ京都, Domestic conference

  Oral presentation


• 1型糖尿病における運動による持続的な糖代謝亢進が遅発性低血糖を引き起こす

  SATO KOJI, 西島 壮, 横川 拓海, 藤田 聡

  第59回日本糖尿病学会年次学術集会, May 2016, Japanese, 国立京都国際会館, Domestic conference

  Oral presentation


• In vivo骨格筋最大収縮に伴う細胞内糖取り込み制御因子の応答

  Kido Kohei, Ato Satoru, Yokokawa Takumi, Makanae Yuhei, SATO KOJI, Fujita Satoshi

  Biochemistry and Molecular Biology 2015, Dec. 2015, Japanese, 神戸ポートアイランド, Domestic conference

  Poster presentation


• 3T3-L1細胞において、dehydroepiandrosteroneはAMPキナーゼの活性化を介して脂肪細胞分化を抑制する

  Yokokawa Takumi, SATO KOJI, Narusawa Ryoko, Kido Kohei, Mori Risako, Iwanaka Nobumasa, Hayashi Tatsuya, Hashimoto Takeshi

  Biochemistry and Molecular Biology 2015, Dec. 2015, Japanese, 神戸ポートアイランド, Domestic conference

  Poster presentation


• The relationship between intramyocellular or extramyocellular lipid contents and cardiovascular disease risks in different cardiorespiratory fitness levels

  Natsuki Hasegawa, Toshiyuki Kurihara, SATO KOJI, Toshiyuki Homma, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu

  20th Annual Congress of the European College of Sport Science, Jun. 2015, English, Malmo, Sweden, International conference

  Oral presentation


• Delayed onset of hypoglycemia after an acute bout of exercise is associated with prolonged muscle GLUT-4 translocation in type 1 diabetes.

  Sato K, Nishijima T, Yokokawa T, Fujita S

  American Diabetes Association75th scientific sessions, Jun. 2015, English, American Diabetes Association, ボストン, International conference

  Oral presentation


• Serum CTRP9 level is associated with arterial stiffness and cardiorespiratory fitness

  Natsuki Hasegawa, SATO KOJI, Shumpei Fujie, Shinya Watanabe, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu

  62th ACSM Annual Meeting, May 2015, English, San Diego, USA, International conference

  Poster presentation


• Chronic chlorella intake and high intensity intermittent exercise enhance exercise capacity and muscular glycolytic enzyme activity in rats.

  Natsuki Hasegawa, SATO KOJI, Naoki Horii, Shumpei Fujie, Toru Mizoguchi, M Onishi, Izumi Tabata, Motoyuki Iemitsu

  12th Asian Congress of Nutrition, May 2015, English, Yokohama, Japan, International conference

  Poster presentation


• 有酸素性トレーニングによる動脈硬化改善と筋細胞内・外脂肪含有量との関係.

  長谷川夏輝, 栗原俊之, 佐藤幸治, 藤田聡, 真田樹義, 浜岡隆文, 家光素行

  日本体力医学会第69回大会, Sep. 2014, Japanese, 日本体力医学会, 長崎, Domestic conference

  Oral presentation


• 肥満モデルラットにおける運動およびDHEA投与が骨格筋の脂質代謝制御転写因子に与える影響.

  堀居直希, 佐藤幸治, 家光素行

  日本体力医学会第69回大会, Sep. 2014, Japanese, 日本体力医学会, 長崎, Domestic conference

  Oral presentation


• 中高齢者における有酸素性トレーニングが血中adropin濃度に及ぼす影響.

  藤江隼平, 佐藤幸治, 長谷川夏輝, 藤田聡, 真田樹義, 浜岡隆文, 家光素行

  日本体力医学会第69回大会, Sep. 2014, Japanese, 日本体力医学会, 長崎, Domestic conference

  Oral presentation


• 高齢者の一過性レジスタンス運動による骨格筋性ステロイド代謝応答はトレーニングによる筋量・筋力増大に関連する.

  佐藤幸治, 家光素行, 松谷健司, 栗原俊之, 目崎登, 浜岡隆文, 藤田聡

  日本体力医学会第69回大会, Sep. 2014, Japanese, 日本体力医学会, 長崎, Domestic conference

  Oral presentation


• 血中C1qレベルは高齢者のレジスタンストレーニングによる筋肥大効果に関連する.

  渡邉真也, 佐藤幸治, 長谷川夏輝, 藤田聡, 栗原俊之, 松谷健司, 浜岡隆文, 家光素行

  日本体力医学会第69回大会, Sep. 2014, Japanese, 日本体力医学会, 長崎, Domestic conference

  Oral presentation


• 肥満ラットの運動トレーニングによる動脈血管拡張因子の改善に動脈Apelin産生の増大が関与する.

  藤江隼平, 佐藤幸治, 長谷川夏輝, 家光素行

  日本運動生理学会第22回大会, Jul. 2014, Japanese, 日本運動生理学会, 岡山, Domestic conference

  Oral presentation


• 体力レベルの違いが筋細胞内・外脂肪含有量と動脈硬化指数の関係に及ぼす影響.

  長谷川夏輝, 佐藤幸治, 藤江隼平, 渡邉真也, 藤田聡, 真田樹義, 大塚光雄, 家光素行

  日本運動生理学会第22回大会, Jul. 2014, Japanese, 日本運動生理学会, 岡山, Domestic conference

  Oral presentation


• 血中C1qレベルは加齢に伴う筋量・筋力の変化に関連する.

  渡邉真也, 佐藤幸治, 長谷川夏輝, 藤田聡, 真田樹義, 家光素行

  日本運動生理学会第22回大会, Jul. 2014, Japanese, 日本運動生理学会, 岡山, Domestic conference

  Oral presentation


• 運動およびジオスゲニン摂取は骨格筋内の性ホルモン増大を介してインスリン抵抗性を改善する.

  佐藤幸治, 藤田聡, 目崎登, 家光素行

  日本運動生理学会第22回大会, Jul. 2014, Japanese, 日本運動生理学会, 岡山, Domestic conference

  Oral presentation


• 運動およびDHEA投与は肥満モデルラットの骨格筋脂質代謝制御転写因子の発現を増大させる.

  堀居直希, 佐藤幸治, 家光素行

  日本運動生理学会第22回大会, Jul. 2014, Japanese, 日本運動生理学会, 岡山, Domestic conference

  Oral presentation


• Effects of intramyocellular and extramyocellular lipid contents on arterial stiffness.

  Hasegawa N, Kurihara T, Sato K, Fujita S, Sanada K, Otsuka M, Hamaoka T, Iemitsu M

  19th Annual Congress, Jun. 2014, English, European College of Sport Science, オランダ, International conference

  Poster presentation


• Effect of central arterial stiffness on acute stretching exercise in young men.

  Yamato Y, Hasegawa N, Sato K, Iemitsu M

  19th Annual Congress, Jun. 2014, English, European College of Sport Science, オランダ, International conference

  Poster presentation


• Reduction of arterial stiffness by exercise training is associated with increasing plasma apelin level.

  Fujie S, Sato K, Miyamoto-Mikami E, Hasegawa N, Fujita S, Sanada K, Hamaoka T, Iemitsu M

  61st Annual Congress, May 2014, English, American College of Sport Medicine, オーランド, International conference

  Poster presentation


• Exercise order of concurrent endurance and resistance exercise modifies mTOR signaling in rat skeletal muscle.

  Ogasawara R, Sato K, Matsutani K, Nakazato K, Fujita S

  61st Annual Congress, May 2014, English, American College of Sport Medicine, オーランド, International conference

  Poster presentation


• Effects of the menstrual cycle on the metabolomic profiles during endurance exercise in female athletes.

  Sakamaki-Sunaga M, Kamemoto K, Maruyama A, Nakamura A, Sato K, Fujita S

  61st Annual Congress, May 2014, English, American College of Sport Medicine, オーランド, International conference

  Poster presentation


• Effects of cardiorespiratory fitness level, age, and sex on intramyocellular and extramyocellular lipid contents.

  Hasegawa N, Kurihara T, Watanabe S, Sato K, Fujita S, Sanada K, Hamaoka T, Iemitsu M

  61st Annual Congress, May 2014, English, American College of Sport Medicine, オーランド, International conference

  Poster presentation


• Dioscorea-induced increase of sex steroid hormone improve hyperglycemia in type 2 diabetic rats.

  Sato K, Fujita S, Iemitsu M

  61st Annual Congress, May 2014, English, American College of Sport Medicine, オーランド, International conference

  Poster presentation


• DHEA administration-induced increase in adiponectin secretion is associated with muscular PPAR-alpha expression in obese rats.

  Horii N, Sato K, Iemitsu M

  61st Annual Congress, May 2014, English, American College of Sport Medicine, オーランド, International conference

  Poster presentation


• Antioxidant inhibits resistance exercise induced phosphorylation of p70s6K in rats.

  Makanae Y, Ogasawara R, Sato K, Matsutani K, Shiozawa N, Nakazato K, Fujita S

  61st Annual Congress, May 2014, English, American College of Sport Medicine, オーランド, International conference

  Poster presentation


• Ageing-induced reduction in muscle cross-sectional area is associated with serum C1q concentration.

  Watanabe S, Sato K, Fujta S, Hasegawa N, Fujie S, Sanada K, Kurihara T, Hamaoka T, Iemitsu M

  61st Annual Congress, May 2014, English, American College of Sport Medicine, オーランド, International conference

  Poster presentation


• 有酸素性運動に伴う筋内アミノ酸濃度とmTORC1の応答.

  松谷健司, 小笠原理紀, 佐藤幸治, 藤田聡

  日本体力医学会第68回大会, Sep. 2013, Japanese, 日本体力医学会, 東京, Domestic conference

  Oral presentation


• 中高齢者における有酸素性トレーニングが血中apelin濃度に及ぼす影響.

  藤江隼平, 佐藤幸治, 藤田聡, 真田樹義, 浜岡隆文, 家光素行

  日本体力医学会第68回大会, Sep. 2013, Japanese, 日本体力医学会, 東京, Domestic conference

  Oral presentation


• 持久性トレーニングによる血中Irishin濃度の変化と内臓脂肪量減少量の関係.

  宮本恵里, 佐藤幸治, 栗原俊之, 藤江隼平, 藤田聡, 真田樹義, 浜岡隆文, 家光素行

  日本体力医学会第68回大会, Sep. 2013, Japanese, 日本体力医学会, 東京, Domestic conference

  Oral presentation


• 高齢者のレジスタンストレーニングによる骨格筋内性ステロイド合成の改善が筋量増大に関連する.

  佐藤幸治, 家光素行, 松谷健司, 栗原俊之, 目崎登, 浜岡隆文, 藤田聡

  日本体力医学会第68回大会, Sep. 2013, Japanese, 日本体力医学会, 東京, Domestic conference

  Oral presentation


• 筋細胞内脂肪含有量と動脈硬化指数の関係.

  長谷川夏輝, 栗原俊之, 佐藤幸治, 藤田聡, 真田樹義, 大塚光雄, 浜岡隆文, 家光素行

  日本体力医学会第68回大会, Sep. 2013, Japanese, 日本体力医学会, 東京, Domestic conference

  Oral presentation


• レジスタンス運動と有酸素性運動の実施順が筋タンパク質同化応答を決定する.

  小笠原理紀, 佐藤幸治, 松谷健司, 中里浩一, 藤田聡

  日本体力医学会第68回大会, Sep. 2013, Japanese, 日本体力医学会, 東京, Domestic conference

  Oral presentation


• 持久能鍛錬者と非鍛錬者の異なる運動負荷における性ホルモン濃度変化の比較.

  佐藤幸治, 家光素行, 片山敬章, 石田浩司, 金尾洋治, 斉藤満

  日本体育学会第64回大会, Jul. 2013, Japanese, 日本体育学会, 滋賀, Domestic conference

  Oral presentation


• 高齢者を対象とした筋力トレーニングにおける強度の違いが筋機能および骨格筋量に及ぼす影響.

  松谷健司, 佐藤幸治, 家光素行, 栗原俊之, 小笠原理紀, 藤田聡

  日本体育学会第64回大会, Jul. 2013, Japanese, 日本体育学会, 滋賀, Domestic conference

  Oral presentation


• アスリートの競技種目の特性に影響する骨格筋タンパクの検索.

  宮本恵里, 佐藤幸治, 藤田聡, 家光素行

  日本体育学会第64回大会, Jul. 2013, Japanese, 日本体育学会, 滋賀, Domestic conference

  Oral presentation


• The cross-sectional study of the relationships among household physical activity, locomotive physical activity and metabolic syndrome risks factors.

  Okumatsu K, Aoki M, Watanabe S, Iemitsu M, Sato K, Kurihara T, Otsuka M, Fujioka M, Fujita S, Hamaoka T, Sanada K

  18th Annual Congress, Jun. 2013, English, European College of Sport Science, スペイン, International conference

  Poster presentation


• Combination of α-Glycerophosphocholine （α-GPC） intake and aerobic exercise improves cognitive functions in healthy older women.

  Yuhaku A, Sato K, Fujita S, Okubo T, Hamaoka T, Iemitsu M

  18th Annual Congress, Jun. 2013, English, European College of Sport Science, スペイン, International conference

  Poster presentation


• Combination of α-Glycerophosphocholine （α-GPC） intake and aerobic exercise enhances growth hormone secretion and fat metabolism in young adults.

  Sato K, Fujie S, Fujita S, Okubo T, Hamaoka T, Iemitsu M

  18th Annual Congress, Jun. 2013, English, European College of Sport Science, スペイン, International conference

  Poster presentation


• コリンサプリメント摂取と運動の併用が成長ホルモン分泌および脂質代謝に及ぼす影響.

  家光素行, 佐藤幸治, 藤江隼平, 大久保剛, 浜岡隆文, 藤田聡

  日本栄養・食糧学会第67回大会, May 2013, Japanese, 日本栄養・食糧学会, 愛知, Domestic conference

  Oral presentation


• ウルソール酸はレジスタンス運動後のラット骨格筋Aktリン酸化を亢進させる.

  小笠原理紀, 佐藤幸治, 東田一彦, 中里浩一, 藤田聡

  日本栄養・食糧学会第67回大会, May 2013, Japanese, 日本栄養・食糧学会, 愛知, Domestic conference

  Oral presentation


• 1型糖尿病モデルラットにおける単回のジオスゲニン投与による骨格筋糖代謝活性と血糖値に及ぼす影響.

  佐藤幸治, 藤田聡, 家光素行

  日本栄養・食糧学会第67回大会, May 2013, Japanese, 日本栄養・食糧学会, 愛知, Domestic conference

  Oral presentation


• Effect of oligomerized polyphenol supplementation on lipid metabolism during exercise in healthy men.

  Miyake T, Sato K, Matsutani K, Iemitsu M, Nishizawa M, Miura T, Isaka T, Fujita S

  Annual Congress 2013, Apr. 2013, English, Experimental Biology, ボストン, International conference

  Poster presentation


• Diosgenin administration improve hyperglycemia through the activation of muscular glucose metabolism.

  Sato K, Fujita S, Iemitsu M

  Annual Congress 2013, Apr. 2013, English, Experimental Biology, ボストン, International conference

  Poster presentation


• 性ステロイドホルモン投与と運動トレーニングが高ショ糖食摂取による肥満ラットに及ぼす影響

  第25回日本トレーニング学会, Nov. 2012


• 運動トレーニングによる性ステロイドホルモン増加は2型糖尿病モデルラットの骨格筋糖代謝を亢進させる.

  佐藤幸治, 藤田聡, 山内秀樹, 北村裕美, 代谷陽子, 湊久美子, 家光素行

  日本体力医学会第67回大会, Sep. 2012, Japanese, 日本体力医学会, 岐阜, Domestic conference

  Oral presentation


• レジスタンス運動後のロイシン高配合必須アミノ酸混合物摂取が筋タンパク質分解の制御に及ぼす影響.

  辻野真史, 家光素行, 佐藤幸治, 松谷健司, 高橋圭, 浜岡隆文, 田中賢治, 平林由理, 小林久峰, 藤田聡

  日本体力医学会第67回大会, Sep. 2012, Japanese, 日本体力医学会, 岐阜, Domestic conference

  Oral presentation


• 異なるタンパク質摂取が運動時の脂質代謝に及ぼす影響.

  高橋圭, 佐藤幸治, 藤田聡

  日本体育学会第63回大会, Aug. 2012, Japanese, 日本体育学会, 神奈川, Domestic conference

  Oral presentation


• ヒト骨格筋に性ステロイドホルモン合成酵素が発現する－加齢による影響－.

  佐藤幸治, 家光素行, 藤田聡

  日本体育学会第63回大会, Aug. 2012, Japanese, 日本体育学会, 神奈川, Domestic conference

  Oral presentation


• Effect of reduced training frequency on muscle mass and serum testosterone in older men.

  Matsutani K, Sato K, Takahashi K, Tsujino M, Kurihara T, Iemitsu M, Hamaoka T, Fujita S

  17th Annual Congress, Jul. 2012, English, European College of Sport Science, ベルギー, International conference

  Poster presentation


• Low-intensity resistance training using an elastic band improves muscle mass and function in older person.

  Matsutani K, Sato K, Iemitsu M, Sanada K, Kurihara T, Kimura T, Isaka T, Hamaoka T, Fujita S

  59th Annual Congress, May 2012, English, American College of Sport Medicine, サンフランシスコ, International conference

  Poster presentation


• Exercise training-induced improvement of impaired muscle glucose metabolism is associated with muscular sex steroid hormone level in Zucker fatty diabetes rats.

  Sato K, Minato K, Fujita S, Yamauchi H, Mesaki N, Iemitsu M

  59th Annual Congress, May 2012, English, American College of Sport Medicine, サンフランシスコ, International conference

  Poster presentation


• 一過性レジスタンス運動時の筋タンパク合成関連シグナル経路調節―加齢の影響.

  佐藤幸治, 家光素行, 松谷健司, 浜岡隆文, 栗原俊之, 内藤久士, 藤田聡

  日本体力医学会第66回大会, Sep. 2011, Japanese, 日本体力医学会, 山口, Domestic conference

  Oral presentation


• コリンサプリメントが成長ホルモン分泌と脂質代謝に与える影響.

  河村隆史, 佐藤幸治, 藤田聡, 大久保剛, 日比野英彦, 後藤一成, 浜岡隆文, 家光素行

  日本体力医学会第66回大会, Sep. 2011, Japanese, 日本体力医学会, 山口, Domestic conference

  Oral presentation


• The role of nutrient intake in Sarcopenia prevention.

  Fujita S, Sato K, Matsutani M, Iemitsu M, Isaka T

  International Conference on Nutrition and Aging6th Congress, Sep. 2011, English, Nutrition and Aging, 東京, International conference

  [Invited]

  Nominated symposium


• 運動による骨格筋内の性ホルモン増大がインスリン抵抗性改善に関連するか？

  佐藤幸治, 家光素行, 相澤勝治, 目崎登, 藤田聡

  日本運動生理学会第19回大会, Aug. 2011, Japanese, 日本運動生理学会, 徳島, Domestic conference

  Oral presentation


• Increased muscular dehydroepiandorosterone levels are associated with improved hyperglycemia in obese rats.

  Sato K, Iemitsu M, Aizawa K, Mesaki N, Fujita S

  16th Annual Congress, Jun. 2011, English, European College of Sport Science, イギリス, International conference

  Poster presentation


• Regulation of hypertrophic signaling pathways to a low-volume resistance exercise in older individuals.

  Sato K, Iemitsu M, Matsutani K, Hamaoka T, Kurihara T, Naito H, Fujita S

  58th Annual Congress, May 2011, English, American College of Sport Medicine, デンバー, International conference

  Poster presentation


• Differential effect of aging on acute hormonal response to resistance exercise.

  Matsutani K, Sato K, Iemitsu M, Hamaoka T, Sanada K, Kurihara T, Kimura T, Isaka T, Fujita S

  58th Annual Congress, May 2011, English, American College of Sport Medicine, デンバー, International conference

  Poster presentation


• DHEA administration and exercise training improves insulin resistance in obese rats.

  Sato K, Iemitsu M, Mesaki N, Tabata I, Fujita S

  International Sportology Conference1st Congress, Mar. 2011, English, Sportology Society, 東京, International conference

  Poster presentation


• DHEA と骨格筋糖代謝活性.

  SATO KOJI

  日本テストステロン研究会 第1回大会, Nov. 2010, Japanese, 東京, Domestic conference

  [Invited]

  Nominated symposium


• Dehydroepiandrosteron (DHEA) と骨格筋糖代謝

  第10回Men’s Health 医学会, Nov. 2010


• DHEA投与が1型糖尿病モデルラットにおける血糖値および骨格筋糖代謝調節経路に及ぼす影響.

  佐藤幸治, 家光素行, 相澤勝治, 藤田聡, 目崎登, 鯵坂隆一, 田畑泉

  第65回大会, Sep. 2010, Japanese, 日本体力医学会, 千葉, Domestic conference

  Poster presentation


• The effect of rice bran arabinoxylan compound on glucose metabolism in skeletal muscle.

  Sato K, Kimura F, Shimizu K, Ikemune S, Kono I, Ajisaka R

  Intersociety meeting 2010, Aug. 2010, English, American Physiological Society, デンバー, International conference

  Poster presentation


• DHEA（Dehydroepiandrosteron） と骨格筋糖代謝活性.

  SATO KOJI

  日本抗加齢医学会 第10回大会, Jun. 2010, Japanese, 京都, Domestic conference

  [Invited]

  Nominated symposium


• Effect of oligomerised polyphenol supplementation on lipid metabolism and endothelial function among young subjects.

  Fujita S, Sato K, Matsutani M, Iemitsu M, Nishizawa M, Miura T, Isaka T

  Nutrition and Integrative Medicine18th Congress, May 2010, English, Nutrition and Integrative Medicine, 北海道, International conference

  [Invited]

  Invited oral presentation


• 肥満型高血糖モデルラットのインスリン抵抗性に対するDHEA摂取および運動療法の単独・併用効果.

  佐藤幸治, 家光素行, 相澤勝治, 鯵坂隆一

  日本体力医学会第63回大会, Sep. 2008, Japanese, 日本体力医学会, 大分, Domestic conference

  Poster presentation


• Exercise stimulates local bioactive androgen metabolism in skeletal muscle.

  Aizawa K, Iemitsu M, Maeda S, Sato K, Otsuki T, Ushida T, Mesaki N, Akimoto T

  Intersociety meeting 2008, Sep. 2008, English, American Physiological Society, ボストン, International conference

  Poster presentation


• Does DHEA affect glucose metabolism in skeletal muscle?

  SATO KOJI

  日本運動生理学会 第16回大会, Aug. 2008, Japanese, 奈良, Domestic conference

  Public discourse


• DHEA activates the glucose metabolism-related signalling pathway in skeletal muscle.

  Sato K, Iemitsu M, Aizawa K, Ajisaka R

  13th Annual Congress, Jul. 2008, English, European College of Sport Science, ポルトガル, International conference

  Poster presentation


• 男性ホルモンは骨格筋の糖代謝に影響する.

  佐藤幸治, 家光素行, 相澤勝治, 鯵坂隆一

  第62回大会, Sep. 2007, Japanese, 日本体力医学会, 秋田, Domestic conference

  Poster presentation


• 肥満を基盤とする代謝性疾患予防に向けた新たな運動療法・栄養介入の可能性

  佐藤 幸治

  第41回日本肥満学会・第38回日本肥満症治療学会

  [Invited]

  Nominated symposium


• 肥満を基盤とする代謝生疾患予防に向けた新たな運動療法・栄養介入の可能性

  Koji Sato

  第41回日本肥満学会・第38回日本肥満症治療学会, Japanese

  [Invited]

  Nominated symposium

• 日本糖尿病学会

  Apr. 2016 - Present


• European College of Sports Science


• American College of Sports Medicine


• Japanese Society of Physical Fitness and Sports Medicine

• Evaluation of postural control system based on the interaction with cardiovascular and respiratory control systems.

  木村 哲也, 木伏 紅緒, 佐藤 幸治, 塩澤 成弘

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2024 - 31 Mar. 2028


• 月経周期に伴う心身不調と睡眠習慣との関連：精神神経内分泌免疫動態からの探索

  松本 珠希, 木村 哲也, 佐藤 幸治

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 四天王寺大学, 01 Apr. 2024 - 31 Mar. 2028


• 中高齢者のトゲドコロイモ摂取における機能性とその効能の解明

  佐藤 幸治, 石原 暢

  日本学術振興会, 科学研究費助成事業, 基盤研究(B), 神戸大学, Apr. 2024 - Mar. 2028


• 心理的ストレスによる不眠予測およびセルフモニタリングツールの開発とその効果検証

  古谷 真樹, 佐藤 幸治, 福田 博也, 近藤 徳彦

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2023 - 31 Mar. 2027


• 中高齢女性特有の疾患における新たな予防策の開発

  佐藤 幸治

  日本学術振興会, 科学研究費助成事業, 国際共同研究加速基金(国際共同研究強化), 神戸大学, Jul. 2024 - Jul. 2026, Principal investigator


• 高度情報化社会に必要な科学関連情報評価能力の育成を促進する教師教育プログラム開発

  山口 悦司, 望月 俊男, 坂本 美紀, 増本 康平, 木村 哲也, 佐藤 幸治, LASSILA ERKKI・TAPIO, 河野 麻沙美

  日本学術振興会, 科学研究費助成事業, 挑戦的研究(萌芽), 神戸大学, 30 Jun. 2023 - 31 Mar. 2026


• A longitudinal study of age-related changes in emotion regulation and trust and their relationship to social connectedness

  増本 康平, 谷口 隆晴, 佐藤 幸治, 原田 和弘

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2022 - 31 Mar. 2025


• 糖尿病予防に向けた新規骨格筋糖代謝調節経路の解明

  佐藤 幸治

  日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2021 - 31 Mar. 2024

  本研究では、運動トレーニングによる2型糖尿病予防に向けた新規骨格筋糖代謝調節経路を確立するために、細胞培養実験を用いて以下の点を解明することを目的とする。 「新規の骨格筋糖代謝調節システムの同定：肥満や2型糖尿病に由来する炎症性サイトカインや酸化ストレスの増加によるOSMの低下が、骨格筋糖代謝調節経路の活性化抑制に関与することを示すとともに、性ステロイドホルモン投与によるOSMの増加が、骨格筋糖代謝調節経路を亢進するか否かを確かめる。」 本年度は課題1を行い、骨格筋培養細胞（C2C12）を対象とし、抗炎症作用等を有するオンコスタチンM(OSM)を遺伝子導入によりノックダウンさせ、骨格筋糖代謝調節経路に及ぼす影響を検討した。遺伝子導入は、OSM抑制のためのshRNAプラスミドベクターを骨格筋細胞に導入し、インスリンやDHEA、DHEAを増加させる栄養成分であるトゲドコロの粉末を骨格筋細胞に添加し、24時間後細胞を回収し、Western Blotting法により、骨格筋の糖代謝調節経路活性及び糖取り込みを検討した。 OSMを欠損した骨格筋細胞において、インスリンやDHEAを添加すると、骨格筋糖代謝調節経路活性や骨格筋による糖取り込みは通常の骨格筋細胞より有意に亢進し、OSMの増加に伴う炎症性サイトカインの増加が、インスリン抵抗性や骨格筋糖代謝活性の不活性化に関与している可能性が示唆された。 また、DHEAやジオスゲニンの投与は、先行研究より、抗炎症作用があることから、本研究においても、添加24時間後の通常の骨格筋細胞においてもOSMの発現が抑制されることが明らかとなった。


• 高度情報化社会に求められる科学関連情報評価能力の育成手法と実践モデルの開発

  山口 悦司, 杉本 雅則, 望月 俊男, 坂本 美紀, 増本 康平, 木村 哲也, 佐藤 幸治

  日本学術振興会, 科学研究費助成事業 挑戦的研究(萌芽), 挑戦的研究(萌芽), 神戸大学, 30 Jul. 2020 - 31 Mar. 2023

  本研究では，近年の学習科学で国際的に着目されている「エピステミック学習理論」を応用し，高度情報化社会に対応した科学関連情報評価能力の理論化を行い，その育成手法と実践モデルの開発に取り組む．研究方法については，この研究目的の達成のために，学際的な共同研究体制を組織している． 2021年度は，科学関連情報評価能力の育成手法と実践モデルの開発，研究実践フィールドにおける実証実験を実施した．2021年度の研究実績については，次の通りであった．（1）前年度の研究から得られた科学関連情報評価に必要な資質・能力・態度に基づいて，科学関連情報評価能力のための教育目的を設定した．（2）科学関連情報評価能力に関する教育内容を開発するとともに，学習科学の研究成果を応用した教育方法を開発した．（3）さらに，量的分析および質的分析の観点から，科学関連情報評価能力に特化した教育評価を開発した．（4）これらの科学関連情報評価能力に特化した教育目的・方法・内容・評価を統合した実践モデルの実証実験を実施し，効果測定のためのデータを収集・分析した．なお，実証実験については，新型コロナウイルス感染症拡大の影響に応じて，その実施方法について検討を行った．2021年度の研究成果の発表に関しては，教育システム情報学会誌，The 19th Biennial EARLI Conference，日本教育工学会2022年春季全国大会，日本科学教育学会第45回年会，日本理科教育学会第71回全国大会において研究成果の一部を発表した．また， International Society of Learning Sciences Annual Meeting 2022に採択された．この他，研究成果の一部を公表した図書が2022年6月に刊行予定である．


• Mechanism and role of emotion regulation in end of life.

  Masumoto Kouhei

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2019 - 31 Mar. 2022

  A series of experiments and surveys suggested that the use of emotion regulation strategies in older age is less affected by age-related decline in cognitive function in the healthy range, and that the quality of information processed (positive or negative information) affects emotion regulation and emotions more than cognitive performance. It was also suggested that the type of emotion regulation strategy used was related to social connectedness and loneliness. On the other hand, the use of others for emotion regulation decreased with age, and emotion regulation used by spouses who had lived together for a long time did not predict their own mental health, suggesting that emotion regulation strategies in old age may be completed within the individual.


• 女子大学生の各性周期における運動刺激に対する生理・生化学的応答の解明

  公益財団法人 戸部眞紀財団, 研究助成, Oct. 2020 - Sep. 2021, Principal investigator


• Regulatory mechanism of muscle hypertrophy by vitamin D intake and exercise for the prevention of sarcopenia

  Fujita Satoshi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Ritsumeikan University, 01 Apr. 2017 - 31 Mar. 2021

  The purpose of this study was to elucidate the molecular function of vitamin D metabolism in the regulation of skeletal muscle mass, and to establish basic data for strategies for efficient sarcopenia prevention. In a cross-sectional study of elderly subjects, a significant relationship was found between blood vitamin D concentration and limb non-fat mass. As an intervention experiment, the expression of VDR increased in both animal and human skeletal muscle following a single session of resistance exercise, indicating that vitamin D metabolism is altered in response to stimuli that increase muscle mass. However, despite the increase in VDR expression associated with denervation, pre-elevated blood vitamin D levels did not prevent denervation-induced muscle atrophy.


• Effect of sex steroid hormones on aerobic exercise training-induced reduction of arterial stiffness

  MESAKI Noboru

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), University of Tsukuba, 01 Apr. 2015 - 31 Mar. 2018

  This study was aimed to clarify whether the secretion of sex steroids hormones is associated with aerobic exercise training-induced reduction of arterial stiffness. To directly evidence exercise effect by using inhibitor of sex steroid hormone synthase, Male obese type 2 diabetic rats (OLETF) were randomly divided into 4 groups; sedentary obese control, 8-week aerobic training, aerobic training with continuous infusion of 5α-reductase inhibitor, or aerobic training with continuous infusion of P450 aromatase inhibitor groups. Aerobic exercise training in OLETF significantly reduced carotid-femoral pulse wave velocity (cfPWV), an index of arterial stiffness, as compared with the sedentary obese control group, whereas the training-induced reduction of cfPWV was not suppressed by administrations of the 5α-reductase and P450 aromatase inhibitors. These results suggest that sex steroids hormones may be not associated with aerobic exercise training-induced reduction of arterial stiffness.


• Development of exercise therapy for reduction of arterial stiffness by exercise-induced secretion of myokines

  Iemitsu Motoyuki, SATO Koji, HAYANO Toshiya

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Ritsumeikan University, 01 Apr. 2014 - 31 Mar. 2017

  This study aimed to clarify whether the association with regular aerobic exercise-induced reduction of arterial stiffness to circulating levels of myokines (apelin and irisin) in middle-aged and older adults. Thirty-four healthy middle-aged and older subjects were divided into two groups: exercise intervention and sedentary controls. Subjects in the training group completed 8-week of aerobic exercise (60-70% peak oxygen uptake for 45 min, 3 days/week). In the training group, arterial stiffness indexes were significantly decreased, and circulating levels of apelin and irisin were significantly increased after the intervention. Additionally, significant negative correlations between the training effects of circulating apelin and irisin levels and arterial stiffness indexes were observed. These results suggest that the increased in circulating apelin and irisin levels may be associated with exercise training-induced alternation of arterial stiffness in middle-aged and older adults.


• New methods to induce skeletal muscle hypertrophy using reactive oxygen species

  Makanae Yuhei, Fujita Satoshi, Nakazato Koichi, Sato Koji, Ogasawara Riki

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, 01 Apr. 2014 - 31 Mar. 2017

  The purpose of this study was to investigate the effects of reactive oxygen species (ROS) injection and the combination of ROS injection and resistance exercise on the mTORC1 activity. The exogenous increase in ROS stimulated mTORC1 activity at basal state. However, it did not further stimulate resistance exercise-induced mTORC1 activation.


• A study for elucidating mechanisms underlying preventive effects of physical activity/exercise training on colon cancer

  Tabata Izumi, Matsuo Kaori, Sato Koji, Higashida Kazuhiko, Miyamoto Eri, Iemitsu Motoyuki, Hamaoka Takahumi, Suemoto Ken, Tsuji Katsunori, Xu Yuzhong, Liu Xin

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Ritsumeikan University, 01 Apr. 2013 - 31 Mar. 2017

  By conducting experiments inculuding in vitro study to human training study, we found a mehanism underlying preventive effects of exercise training, especially high intensity intermittent exercise training, on colon cancer development as folows. First, high intensity intermittent exercise elevated AMPK whose activitiy is exercise-intensity dependent, Second, AMPK activation enahces PGC1α expression in exercised muscle. Third, PGC1αinduced SPARC protein. Forth, this increased expression of SPARC elvated its serum concentrataion after exercise.The incrased concentration of SPARC which is kwnon to induce aptosis of pre-cancer cell of ACF in colon may reduce risk of developing colon cancer.


• 1型糖尿病における運動誘発性遅発低血糖の発生機序の解明〜1型糖尿病患者の新規運動ガイドライン作成に向けて〜

  公益財団法人石本記念デサントスポーツ科学振興財団, Apr. 2016 - Mar. 2017, Principal investigator


• 1 型糖尿病における運動による遅発性低血糖発症のメカニズムの解明 —遺伝子およびタンパク質網羅解析による原因究明—

  公益財団法人日本糖尿病財団コストコ研究助成, Apr. 2016 - Mar. 2017, Principal investigator


• Mechanisms of exercise-induced muscle hypertrophy

  OGASAWARA Riki, FUJITA Satoshi, NAKAZATO Koichi, SATO Koji

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, The University of Tokyo, 01 Apr. 2013 - 31 Mar. 2015

  The purpose of the study was to investigate the effect of resistance exercise and aging on extracellular matrix (ECM) related proteins. Resistance exercise activates MMP-2 and MMP-9 during initial phase of resistance training but this response is attenuated with continuation of resistance training in rats. Resistance training increased β1-integrin (cell adhesion molecule) expression but not the other ECM proteins. Increases in integrins (α7- and β1-integrin) and reduced MMPs activities were also observed in older men compared with young men. These results suggest that integrins and MMPs play important role in the exercise-induced muscle hypertrophy.


• Exercise and sex steroid hormones in skeletal muscle.

  MESAKI Noboru, IEMITSU Motoyuki, SATO Koji, AIZAWA Katsuji

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), University of Tsukuba, 01 Apr. 2012 - 31 Mar. 2015

  Skeletal muscle can synthesize testosterone and 5α-dihydrotestosterone (DHT) from dehydroepiandrosterone (DHEA) via steroidogenic enzymes, but hormone levels and steroidogenic enzyme expression decline with aging. However, it remains unclear whether resistance training can restore impaired steroidogenic enzyme expressions in older individuals. In this study, muscular sex steroid hormone levels and sex steroidgenesis-related enzyme expressions were significantly lower in older subjects than younger ones at baseline, but 12 wk of resistance training significantly restored hormone levels (each P<0.05). Furthermore, the steroidogenesis-related enzymes such as 3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD, and 5α-reductase expressions were significantly restored by resistance training. We conclude progressive resistance training restores age-related declines in sex steroidogenic enzyme and muscle sex steroid hormone levels in older men.


• The exercise-induced alternation of muscular steroidgenesis in human

  Sasakawa Scientific Foundation, Apr. 2012 - Mar. 2013

  Competitive research funding


• The effects of exercise and nutrition intake on muscular steroidgenesis in human

  Yamaha Motor Foundation for Sports, Apr. 2012 - Mar. 2013

  Competitive research funding


• The effect of exercise and diosgenin induced increase of sex steroid hormone on type 2 diabetes

  SATO Koji

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Ritsumeikan University, 2011 - 2013

  In study 1, acute dehydroepiandrosterone (DHEA) administration improves hyperglycemia in rats with streptozotocin (STZ)-induced type 1 diabetes mellitus. Diosgenin, a steroid structurally similar to DHEA (dehydroepiandrosterone), however, it is still unclear whether diosgeninimproves hyperglycemia in the type 1 diabetes model rats through an increase muscular GLUT4 signaling. As a result, diosgenin injections decreased blood glucose level. Moreover, GLUT4 translocation, as well as phosphorylation of Akt and PKC, increased significantly by diosgenin or dioscorea administration. In study 2, we determined whether chronic diosgenin administration improve insulin resistance in type 2 diabetes model rat. 8-week diosgenin administration significantly improved fasting blood glucose level and insulin resistance. Accordingly, diosgenin administration may be possible new therapetic candidates for type 1 and 2 diabetes.