Research activity information

• 2025 日本分析化学会, 女性Analyst賞, 生体・人工高分子を分子認識素子に用いるピペットチップセンシングプラットフォームの開発

  髙野恵里

  共同研究・競争的資金等の業績IDIRI


• 2019 クロマトグラフィー科学会, 第26回クロマトグラフィーシンポジウム Best Presentation Award, バイオマーカーの生物発光・蛍光検出のためのピペットチップ型自動センシングプラットフォームの開発

  高野恵里, 志村宣明, 鵜嶋 善久, 濱田 和幸, 竹内 俊文

• Single-Extracellular-Vesicle Detection with a Plasmonic Chip and Enhanced Fluorescence Microscopy

  Kazuma Fukutomi, Eri Fujimoto, Masaya Shimokawatoko, Eri Takano, Hirobumi Sunayama, Toshifumi Takeuchi, Keiko Tawa

  American Chemical Society (ACS), Oct. 2024, ACS Omega

  Scientific journal


• Facile biotic/abiotic sandwich detection system for the highly sensitive detection of human serum albumin and glycated albumin

  Hirobumi Sunayama, Chehasan Cheubong, Eri Takano, Toshifumi Takeuchi

  Abstract Quantifying glycated albumin (GA) levels in the blood is crucial for diagnosing diabetes because they strongly correlate with blood glucose concentration. In this study, a biotic/abiotic sandwich assay was developed for the facile, rapid, and susceptible detection of human serum albumin (HSA) and GA. The proposed sandwich detection system was assembled using a combination of two synthetic polymer receptors and natural antibodies. Molecularly imprinted polymer nanogels (MIP-NGs) for HSA (HSA-MIP-NGs) were used to mimic capture antibodies, whereas antibodies for HSA or GA were used as primary antibodies and fluorescent signaling MIP-NGs for the Fc domain of IgG (F-Fc-MIP-NGs) were used as a secondary antibody mimic to indicate the binding events. The HSA/anti-HSA/F-Fc-MIP-NGs complex, formed by incubating HSA and anti-HSA antibodies with F-Fc-MIP-NGs, was captured by HSA-MIP-NGs immobilized on the chips for fluorescence measurements. The analysis time was less than 30 min, and the limit of detection was 15 pM. After changing the anti-HSA to anti-GA (monoclonal antibody), the fluorescence response toward GA exceeded that of HSA, indicating successful GA detection using the proposed sandwich detection system. Therefore, the proposed system could change the detection property by changing a primary antibody, indicating that this system can be applied to various target proteins and, especially, be a powerful approach for facile and rapid analysis methods for proteins with structural similarity. Graphical Abstract

  Springer Science and Business Media LLC, Jul. 2024, Analytical and Bioanalytical Chemistry

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A rapid abiotic/biotic hybrid sandwich detection for trace pork adulteration in halal meat extract

  Chehasan Cheubong, Hirobumi Sunayama, Eri Takano, Yukiya Kitayama, Hideto Minami, Toshifumi Takeuchi

  A novel sandwich detection was demonstrated for 0.01 wt% pork adulteration within 30 min, using PSA-imprinted polymer nanogels to capture PSA and anti-PSA antibody complexed with-Fc-domain imprinted fluorescent polymer nanogels to detect PSA.

  Royal Society of Chemistry (RSC), 2023, Nanoscale, 15(37) (37), 15171 - 15178

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Biocompatible polymer-modified gold nanocomposites of different shapes as radiation sensitizers

  Aoi Yoshida, Yukiya Kitayama, Natsuki Hayakawa, Yuki Mizukawa, Yuya Nishimura, Eri Takano, Hirobumi Sunayama, Toshifumi Takeuchi

  Biocompatible polymer-modified gold nanocomposites of different shapes (nanoparticles, rods, and stars) were created to serve as radiation sensitizers. The therapeutic effect of the radiated nanostars proved to be the most effective.

  Royal Society of Chemistry (RSC), May 2022, Biomaterials Science, 10(10) (10), 2665 - 2672

  [Refereed]

  Scientific journal


• Fc Domain-Imprinted Stealth Nanogels Capable of Orientational Control of Immunoglobulin G Adsorbed In Vivo

  Natsuki Hayakawa, Yukiya Kitayama, Kazunori Igarashi, Yu Matsumoto, Eri Takano, Hirobumi Sunayama, Toshifumi Takeuchi

  American Chemical Society (ACS), Apr. 2022, ACS Applied Materials & Interfaces, 14(14) (14), 16074 - 16081

  Scientific journal


• In vivo stealthified molecularly imprinted polymer nanogels incorporated with gold nanoparticles for radiation therapy

  Yukiya Kitayama, Takuya Yamada, Kentaro Kiguchi, Aoi Yoshida, Shuhei Hayashi, Hiroaki Akasaka, Kazunori Igarashi, Yuya Nishimura, Yu Matsumoto, Ryohei Sasaki, Eri Takano, Hirobumi Sunayama, Toshifumi Takeuchi

  Gold-nanoparticle-incorporated molecularly imprinted nanogels acquire stealth capabilities in vivo through protein corona regulation using intrinsic dysopsonic proteins. The composite can be used in radiation therapy to treat mouse pancreatic cancer.

  Royal Society of Chemistry (RSC), 2022, Journal of Materials Chemistry B, in press

  [Refereed]

  Scientific journal


• Fluorescent Signaling of Molecularly Imprinted Nanogels Prepared via Postimprinting Modifications for Specific Protein Detection

  Katsuki Tsutsumi, Hirobumi Sunayama, Yukiya Kitayama, Eri Takano, Yuji Nakamachi, Ryohei Sasaki, Toshifumi Takeuchi

  Wiley, Apr. 2021, Advanced NanoBiomed Research, 1(4) (4), 2000079 - 2000079

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Simultaneous Detection of Two Tumor Marker Proteins Using Dual-Colored Signaling Molecularly Imprinted Polymers Prepared via Multi-Step Post-Imprinting Modifications

  Hirobumi Sunayama, Kazuhiro Takamiya, Eri Takano, Ryo Horikawa, Yukiya Kitayama, Toshifumi Takeuchi

  The Chemical Society of Japan, Feb. 2021, Bulletin of the Chemical Society of Japan, 94(2) (2), 525 - 531

  Scientific journal


• Molecularly imprinted polymer nanogel-based fluorescence sensing of pork contamination in halal meat extracts

  Chehasan Cheubong, Eri Takano, Yukiya Kitayama, Hirobumi Sunayama, Kazuaki Minamoto, Ryota Takeuchi, Shunsuke Furutani, Toshifumi Takeuchi

  Elsevier BV, Jan. 2021, Biosensors and Bioelectronics, 172, 112775 - 112775

  Scientific journal


• Antibody-Conjugated Signaling Nanocavities Fabricated by Dynamic Molding for Detecting Cancers Using Small Extracellular Vesicle Markers from Tears.

  Toshifumi Takeuchi, Kisho Mori, Hirobumi Sunayama, Eri Takano, Yukiya Kitayama, Taku Shimizu, Yuzuki Hirose, Sachiko Inubushi, Ryohei Sasaki, Hirokazu Tanino

  Small extracellular vesicles (sEVs) are reliable biomarkers for early cancer detection; however, conventional detection methods such as immune-based assays and microRNA analyses are not very sensitive and require sample pretreatments and long analysis time. Here, we developed a molecular imprinting-based dynamic molding approach to fabricate antibody-conjugated signaling nanocavities capable of size recognition. This enabled the establishment of an easy-to-use, rapid, sensitive, pretreatment-free, and noninvasive sEV detection platform for efficient sEV detection-based cancer diagnosis. An apparent dissociation constant was estimated to be 2.4 × 10-16 M, which was ∼1000 times higher than that of commercial immunoassays (analysis time, 5 min/sample). We successfully used tears for the first time to detect cancer-related intact sEVs, clearly differentiating between healthy donors and breast cancer patients, as well as between samples collected before and after total mastectomy. Our nanoprocessing strategy can be easily repurposed for the specific detection of other types of cancer by changing the conjugated antibodies, thereby facilitating the establishment of liquid biopsy for early cancer diagnosis.

  Apr. 2020, Journal of the American Chemical Society, 142(14) (14), 6617 - 6624, English, International magazine

  [Refereed]


• Signalling molecular recognition nanocavities with multiple functional groups prepared by molecular imprinting and sequential post-imprinting modifications for prostate cancer biomarker glycoprotein detection

  Tetsuro Saeki, Eri Takano, Hirobumi Sunayama, Yuri Kamon, Ryo Horikawa, Yukiya Kitayama, Toshifumi Takeuchi

  Novel sequential post-imprinting modifications were demonstrated on the development of multi-functionalized molecularly imprinted polymers for a biomarker glycoprotein.

  Royal Society of Chemistry (RSC), 2020, Journal of Materials Chemistry B, 8(35) (35), 7987 - 7993

  Scientific journal


• A Pretreatment‐Free, Polymer‐Based Platform Prepared by Molecular Imprinting and Post‐Imprinting Modifications for Sensing Intact Exosomes (Angew. Chem. 6/2019)

  Kisho Mori, Mitsuhiro Hirase, Takahiro Morishige, Eri Takano, Hirobumi Sunayama, Yukiya Kitayama, Sachiko Inubushi, Ryohei Sasaki, Masakazu Yashiro, Toshifumi Takeuchi

  Wiley, Feb. 2019, Angewandte Chemie, 131(6) (6), 1536 - 1536, English

  [Refereed]

  Scientific journal


• Inside Cover: A Pretreatment‐Free, Polymer‐Based Platform Prepared by Molecular Imprinting and Post‐Imprinting Modifications for Sensing Intact Exosomes (Angew. Chem. Int. Ed. 6/2019)

  Kisho Mori, Mitsuhiro Hirase, Takahiro Morishige, Eri Takano, Hirobumi Sunayama, Yukiya Kitayama, Sachiko Inubushi, Ryohei Sasaki, Masakazu Yashiro, Toshifumi Takeuchi

  Wiley, Feb. 2019, Angewandte Chemie International Edition, 58(6) (6), 1522 - 1522, English

  [Refereed]

  Scientific journal


• A Pretreatment-Free, Polymer-Based Platform Prepared by Molecular Imprinting and Post-Imprinting Modifications for Sensing Intact Exosomes

  Kisho Mori, Mitsuhiro Hirase, Takahiro Morishige, Eri Takano, Hirobumi Sunayama, Yukiya Kitayama, Sachiko Inubushi, Ryohei Sasaki, Masakazu Yashiro, Toshifumi Takeuchi

  Feb. 2019, Angew. Chem. Int. Ed., 58(6) (6), 1612 - 1615, English

  [Refereed]

  Scientific journal


• Post-imprinting-modified Molecularly Imprinted Nanocavities with Two Synergetic, Orthogonal, Glycoprotein-Binding Sites to Transduce Binding Events into Fluorescence Changes

  Takahiro Morishige, Eri Takano, Hirobumi Sunayama, Yukiya Kitayama, Toshifumi Takeuchi

  Feb. 2019, ChemNanoMat, 5(2) (2), 224 - 229, English

  [Refereed]

  Scientific journal


• Highly Sensitive Fluoro-immunosensing for Biomarker Detection Using An Automatic Pipette Tip-Type Biosensing System

  Eri Takano, Nobuaki Shimura, Yoshihisa Ujima, Hirobumi Sunayama, Yukiya Kitayama, Toshifumi Takeuchi

  Jan. 2019, ACS Omega, 4(1) (1), 1487 - 1493, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Pipette tip biosensors for bacterial double-stranded DNA using bioluminescence induced by zinc finger luciferase

  Takano, Eri, Shimura, Nobuaki, Akiba, Takeshi, Kitayama, Yukiya, Sunayama, Hirobumi, Abe, Koichi, Ikebukuro, Kazunori, Takeuchi, Toshifumi

  The authors describe a pipette type of biosensor for detecting target genes and using a zinc finger protein fused to luciferase (ZF luciferase). The ZF protein binds to a specific DNA sequence, and the target double-stranded (ds) DNA can be detected by monitoring the enzymatic activity of ZF luciferase. A small avidin-immobilized reaction plate is placed on a plastic pipette tip (referred to as Biologi tip). The dsDNA detection procedures are carried out by using a programmable dispensing robot equipped with a photodetector. These procedures include (a) the aspiration of an analyte to capture the biotinylated target dsDNA (a product of a polymerase chain reaction) on the small reaction plate inside the pipette tip, (b) the introduction of ZF luciferase and luciferin into the pipette tip, and (c) migration of the pipette tip to the detection port to measure bioluminescence on the small reaction plate. The emission originating from luciferase activity is observed on the reaction plate containing immobilized biotin-tagged target dsDNA, whereas plates containing non-target or biotinylated single-stranded DNA only do not yield a signal. The intensity of emission increases proportionally

  SPRINGER WIEN, Jun. 2017, MICROCHIMICA ACTA, 184(6) (6), 1595 - 1601, English

  [Refereed]

  Scientific journal


• A Programmable Signaling Molecular Recognition Nanocavity Prepared by Molecular Imprinting and Post-Imprinting Modifications

  HORIKAWA Ryo, SUNAYAMA Hirobumi, KITAYAMA Yukiya, TAKANO Eri, TAKEUCHI Toshifumi

  Wiley, Oct. 2016, Angewandte Chemie International Edition, 55(42) (42), 13023–13027, English

  [Refereed]

  Scientific journal


• A molecularly imprinted nanocavity-based fluorescence polarization assay platform for cortisol sensing

  Nobuo Murase, Shin-ichi Taniguchi, Eri Takano, Yukiya Kitayama, Toshifumi Takeuchi

  2016, JOURNAL OF MATERIALS CHEMISTRY B, 4(10) (10), 1770 - 1777, English

  [Refereed]

  Scientific journal


• Molecularly Imprinted Polymer Arrays as Synthetic Protein Chips Prepared by Transcription-type Molecular Imprinting by Use of Protein-Immobilized Dots as Stamps

  Takahiro Kuwata, Akane Uchida, Eri Takano, Yukiya Kitayama, Toshifumi Takeuchi

  Dec. 2015, ANALYTICAL CHEMISTRY, 87(23) (23), 11784 - 11791, English

  [Refereed]

  Scientific journal


• Fluorescence Reporting of Binding Interactions of Target Molecules with Core-Shell-Type Cortisol-Imprinted Polymer Particles Using Environmentally Responsible Fluorescent-Labeled Cortisol

  Nobuo Murase, Shin-Ichi Taniguchi, Eri Takano, Yukiya Kitayama, Toshifumi Takeuchi

  Jul. 2015, MACROMOLECULAR CHEMISTRY AND PHYSICS, 216(13) (13), 1396 - 1404, English

  [Refereed]

  Scientific journal


• Synthesis of Monodispersed Submillimeter-Sized Molecularly Imprinted Particles Selective for Human Serum Albumin Using Inverse Suspension Polymerization in Water-in-Oil Emulsion Prepared Using Microfluidics

  Kyohei Takimoto, Eri Takano, Yukiya Kitayama, Toshifumi Takeuchi

  May 2015, LANGMUIR, 31(17) (17), 4981 - 4987, English

  [Refereed]

  Scientific journal


• Transcription-Type Protein Imprinted Polymers for SPR Sensing Prepared Using Target-immobilized Stamps based on Submicrometer-Sized Particles via Biotin-Avidin Linkage

  Satoshi Yoshizawa, Takahiro Kuwata, Eri Takano, Yukiya Kitayama, Toshifumi Takeuchi

  Transcribed molecularly imprinted polymers (MIPs), prepared by using the biotinylated submicrometersized particles-immobilized stamp on which the biotinconjugated protein was hierarchically immobilized via avidin, were used successfully in the recognition of cytochrome c (Cyt) as a model protein. The transcribed MIP for Cyt was prepared on the gold-coated surface plasmon resonance (SPR) sensor chip, and the binding behavior of Cyt, myoglobin, ribonuclease A, lysozyme, and avidin was evaluated to confirm the selectivity for Cyt. The imprint effect of the transcribed MIP was revealed by comparing the MIP and the corresponding non-imprinted polymer prepared using the stamp without the Cyt immobilization.

  Walter de Gruyter GmbH, Jan. 2015, Molecular Imprinting, 3(1) (1), 26 - 34, English

  [Refereed]

  Scientific journal


• Post-imprinting and In-Cavity Functionalization

  Takeuchi Toshifumi, Sunayama Hirobumi, Takano Eri, Kitayama Yukiya

  2015, Molecularly Imprinted Polymers in Biotechnology, 150, 95 - 106

  [Refereed]


• Preparation of Molecularly imprinted polymers for the recognition of proteins via the generation of peptide-fragment binding sites by semi-covalent imprinting and enzymatic digestion

  TAGUCHI Hironori, SUNAYAMA Hirobumi, TAKANO Eri, KITAYAMA Yukiya, TAKEUCHI Toshifumi

  Royal Society of Chemistry, Jan. 2015, Analyst, 140, 1448 - 1452, English

  [Refereed]

  Scientific journal


• Supraparticles comprised of molecularly imprinted nanoparticles and modified gold nanoparticles as a nanosensor platform

  UCHIDA Akane, KITAYAMA Yukiya, TAKANO Eri, OOYA Tooru, TAKEUCHI Toshifumi

  Royal Society of Chemistry, Nov. 2013, RSC Advances, 3, 25306 - 25311, English

  [Refereed]

  Scientific journal


• Dummy Template-Imprinted Polymers for Bisphenol A Prepared Using a Schiff Base-Type Template Molecule with Post-Imprinting Oxidation

  TAKANO Eri, TAGUCHI Yuki, OOYA Tooru, TAKEUCHI Toshifumi

  Jun. 2012, Analytical Letters, 45(10) (10), 1204 - 1213, English

  [Refereed]

  Scientific journal


• SPR Sensing of Bisphenol A Using Molecularly Imprinted Nanoparticles Immobilized on Slab Optical Waveguide withConsecutive Parallel Au and Ag Deposition Bands Coexistent withBisphenol A-Immobilized Au Nanoparticles

  TAGUCHI Yuki, TAKANO Eri, TAKEUCHI Toshifumi

  May 2012, Langmuir, 28(17) (17), 7083 - 7088, English

  [Refereed]

  Scientific journal


• Molecularly Imprinted Microspheres for Bisphenol A Prepared Using a Microfluidic Device

  TAKANO Eri, TANAKA Fujimaru, OOYA Tooru, TAKEUCHI Toshifumi

  The Japan Society for Analytical Chemistry, May 2012, Analytical Sciences, 28(5) (5), 457 - 461, English

  [Refereed]

  Scientific journal


• Site-specific post-imprinting modification of molecularly imprinted polymer nanocavities with a modifiable functional monomer for prostate cancer biomarker recognition

  Hiroki Matsumoto, Hirobumi Sunayama, Yukiya Kitayama, Toshifumi Takeuchi, Eri Takano

  Sci. Technol. Adv. Mater., in press, English

  [Refereed]

  Scientific journal

• インタクトエクソソームによる乳がん高速検知のための抗体融合分子インプリントセンシングチップ

  竹内俊文, 森貴翔, 清水拓, 広瀬柚月, 高野恵里, 砂山博文, 北山雄己哉, 犬伏祥子, 佐々木良平, 谷野裕一

  2019, 応用物理学会秋季学術講演会講演予稿集(CD-ROM), 80th


• 分子インプリントポリマー修飾プラズモニックチップによるヒト血清アルブミンの高感度プラズモニックセンシング

  松浦亮, 高野恵里, 田和圭子, 砂山博文, 北山雄己哉, 竹内俊文

  2016, 応用物理学会春季学術講演会講演予稿集(CD-ROM), 63rd


• 分子インプリントポリマーを用いた2‐アントラセンカルボン酸キラル光反応場の構築

  中井智史, 高野恵里, 砂山博文, 北山雄己哉, 西嶋政樹, 井上佳久, 和田健彦, 竹内俊文

  11 Mar. 2015, 日本化学会講演予稿集, 95th(3) (3), 779, Japanese


• 分子インプリントポリマーを反応場とした2‐Anthracenecarboxylic acidの光二量化反応

  中井智史, 高野恵里, 砂山博文, 北山雄己哉, 和田健彦, 竹内俊文

  03 Sep. 2014, 高分子学会予稿集(CD-ROM), 63(2) (2), ROMBUNNO.3W02, Japanese


• 分子インプリントポリマー存在下における2‐anthracenecarboxylic acidの光二量体化反応

  中井智史, 高野恵里, 砂山博文, 北山雄己哉, 和田健彦, 竹内俊文

  09 May 2014, 高分子学会予稿集(CD-ROM), 63(1) (1), ROMBUNNO.2PB050, Japanese

• Post-imprinting and in-cavity functionalization , In: Mattiasson, B., Ye, L. Eds. Molecularly Imprinted Polymers in Biotechnology

  TAKEUCHI Toshifumi, SUNAYAMA Hirobumi, TAKANO Eri, KITAYAMA Yukiya

  Joint work, Springer, Apr. 2015, English, ISBN: 9783319207285

  Scholarly book

• 生体・人工高分子を分子認識素子に用いるピペットチップセンシングプラットフォームの開発

  髙野 恵里

  分析化学会第74年会

  [Invited]


• 微小基板内蔵ピペットチップ型自動バイオセンシングシステムによるバイオマーカータンパク質の高感度検出

  TAKANO Eri, SHIMURA Nobuaki, AKIBA Takeshi, TAKUCHI Toshifumi

  第64回応用物理学会春季学術講演会, Mar. 2017, Japanese, 応用物理学会, 横浜市, Domestic conference

  Poster presentation


• ピペットチップ型蛍光イムノセンシングシステムによる腫瘍マーカーの高感度蛍光検出

  TAKANO Eri, SHIMURA Nobuaki, AKIBA Takeshi, TAKEUCHI Toshifumi

  日本化学会第97春季年会2017, Mar. 2017, Japanese, 日本化学会, 横浜市, Domestic conference

  Poster presentation


• がんマーカーセンシングのための微小反応板内蔵ピペットチップ型バイオセンサシステム

  TAKEUCHI Toshifumi, KITAYAMA Yukiya, TAKANO Eri, MATSUMOTO Hiroki

  工学フォーラム2016, Nov. 2016, Japanese, 神戸大学, 神戸市, Domestic conference

  Poster presentation


• 分子インプリントポリマーを認識素子とするタンパク質の格子結合型表面プラズモン励起増強蛍光検出

  MATSUURA Ryo, TAKANO Eri, SUNAYAMA Hirobumi, KITAYAMA Yukiya, TAWA Keiko, TAKEUCHI Toshifumi

  日本分析化学会第65年会, Sep. 2016, Japanese, 日本分析化学会, 札幌市, Domestic conference

  Poster presentation


• 分子インプリントポリマーアレイによるタンパク質の蛍光分析

  KUWATA Takahiro, TAKANO Eri, KITAYAMA Yukiya, TAKEUCHI Toshifumi

  日本分析化学会第65年会, Sep. 2016, Japanese, 日本分析化学会, 札幌市, Domestic conference

  Oral presentation


• アルブミン選択的結合能を有するサブミリメートルサイズ分子インプリントポリマー粒子の合成

  KITAYAMA Yukiya, TAKIMOTO Kyohei, TAKANO Eri, TAKEUCHI Toshifumi

  第29回バイオメディカル分析科学シンポジウム, Sep. 2016, Japanese, 日本薬学会物理系薬学部会, 京都市, Domestic conference

  Oral presentation


• Fluorescence sensing of proteins using surface plasmon excitation enhancing chips grafted by artificial polymeric receptors

  MATSUURA Ryo, TAKANO Eri, TAWA Keiko, KITAYAMA Yukiya, TAKEUCHI Toshifumi

  The 9th International Conference on Molecular Imprinting (MIP2016), Jun. 2016, English, The Society for Molecular Imprinting, Lund,Sweden, International conference

  Poster presentation


• 分子インプリントポリマー修飾プラズモニックチップによるヒト血清アルブミンの高感度プラズモニックセンシング

  MATSUURA Ryo, TAKANO Eri, TAWA Keiko, SUNAYAMA Hirobumi, KITAYAMA Yukiya, TAKEUCHI Toshifumi

  応用物理学会第63回応用物理学会春季学術講演会, Mar. 2016, Japanese, 応用物理学会, 東京都目黒区, Domestic conference

  Oral presentation


• Development of pipette tip-type biosensor for automated bioluminescence detection of target genes in pathogensDevelopment of pipette tip-type biosensor for automated bioluminescence detection of target genes in pathogens

  TAKANO Eri, SHIMURA Nobuaki, IKEBUKURO Kazunori, TAKEUCHI Toshifumi

  The International Chemical Congress of Pacific Basin Societies 2015, Dec. 2015, English, American Chemical Society, Honolulu, Hawaii, USA, International conference

  Poster presentation


• 抗体を配向固定化した金基板を組み込んだピペットチップ型自動がん腫瘍マーカーアッセイシステムの構築

  TAKANO Eri, TAKEUCHI Toshifumi

  クロマトグラフィー科学会第26回クロマトグラフィー科学会議, Nov. 2015, Japanese, クロマトグラフィー科学会, 福岡市, Domestic conference

  Oral presentation


• 抗体を配向固定化した免疫反応場を用いたピペットチップ型自動アッセイシステムによるバイオマーカーの蛍光検出

  TAKANO Eri, TAKEUCHI Toshifumi

  日本分析化学会第64年会, Sep. 2015, Japanese, 日本分析化学会, 福岡市, Domestic conference

  Oral presentation


• ポストインプリンティング修飾による情報発信型分子インプリント空間の構築とがんマーカーの高感度蛍光検出

  HORIKAWA Ryo, SUNAYAMA Hirobumi, TAKANO Eri, KITAYAMA Yukiya, TAKEUCHI Toshifumi

  日本分析化学会第64年会, Sep. 2015, Japanese, 日本分析化学会, 福岡市, Domestic conference

  Poster presentation


• 免疫反応場を組み込んだピペットチップ型自動腫瘍マーカーアッセイ法の開発

  TAKANO Eri, SHIMURA Nobuaki, KITAYAMA Yukiya, TAKEUCHI Toshifumi

  日本分析化学会第75回分析化学討論会, May 2015, Japanese, 日本分析化学会, 甲府市, Domestic conference

  Oral presentation


• 化学修飾金ナノ粒子を用いた分子インプリントナノ粒子の分子認識挙動のSPR解析

  TAKANO Eri, ITO Aruto, OOYA Tooru, TAKEUCHI Toshifumi

  第61回高分子討論会, Sep. 2012, Japanese, 高分子学会, 名古屋市, Domestic conference

  Oral presentation


• Bisphenol A-imprinted nanoparticles for SPR sensing with SLAB optical waveguide bearing parallel Au and Ag deposition bands

  TAGUCHI Yuki, TAKANO Eri, TAKEUCHI Toshifumi

  The 7th International Conference on Molecular Imprinting (MIP2012), Aug. 2012, English, Society for Molecular Imprinting, Paris, France, International conference

  Poster presentation


• 分子インプリントナノ粒子を用いたスラブ型光導波路SPRセンシング

  TAGUCHI Yuki, TAKANO Eri, TAKEUCHI Toshifumi

  第１９回クロマトグラフィーシンポジウム, May 2012, Japanese, クロマトグラフィー科学会, 八王子市, Domestic conference

  Oral presentation

• 涙を用いた卵巣がんの早期発見のための非浸襲・迅速・超高感度細胞外小胞検出法の開発

  高野 恵里, 國久 智成, 寺井 義人

  日本学術振興会, 科学研究費補助金, 基盤研究(B), 神戸大学, Apr. 2021 - Mar. 2024, Principal investigator


• ピペットチップ型アッセイシステムによるがん変異腫瘍マーカーの高感度検出

  高野 恵里

  科学研究費補助金／若手研究, Apr. 2018 - Mar. 2021, Principal investigator

  Competitive research funding


• 表面プラズモン励起増強蛍光を用いたピペットチップ型腫瘍マーカーイムノセンサの構築

  高野 恵里

  学術研究助成基金助成金／基盤研究(C), Apr. 2015 - Mar. 2018, Principal investigator

  Competitive research funding


• 人工高分子レセプター薄膜を用いたピペットチップ型標的分子選択的小型センシングロボット

  高野 恵里

  研究成果展開事業（マッチングプランナー プログラム）, 2016, Principal investigator

  Competitive research funding


• レチノール選択的分子インプリントポリマーを用いた肉牛品質検査法の開発

  高野 恵里

  研究成果展開事業（マッチングプランナー プログラム）, 2016, Principal investigator

  Competitive research funding