Research activity information

• Mar. 2019 Japanese Society of Cartilage Metabolism, The 24th Award Paper of Japanese Society of Cartilage Metabolism, Cyclin-dependent Kinase Inhibitor-1-deficient Mice are susceptible to Osteoarthritis Associated with Enhanced Inflammation

  Shinsuke Kihara, Shinya Hayashi, Shingo Hashimoto, Noriyuki Kanzaki, Koji Takayama, Tomoyuki Matsumoto, Nobuaki Chinzei, Kenjiro Iwasa, Masahiko Haneda, Kazuhiro Takeuchi, Kotaro Nishida, Ryosuke Kuroda


• Nov. 2015 日本バイオマテリアル学会, Journal of Materials chemistry B賞, エイコサペンタエン酸は酸化ストレス依存性の軟骨細胞の変性、アポトーシスを抑制する

  木原伸介, Hayashi Shinya, 明石祐典, 永田純平, 竹内一裕, 羽田勝彦, 鎮西伸顕, Kanzaki Noriyuki, 橋本慎吾, 黒田良祐, 田畑泰彦, Kurosaka Masahiro

  Japan society

• SPRR1A is a potential therapeutic target for osteosarcoma: in vitro and in vivo evaluations using generated artificial osteosarcoma cancer stem cell‑like cells.

  Tomohiro Miyamoto, Naomasa Fukase, Teruya Kawamoto, Shuichi Fujiwara, Hitomi Hara, Ryoko Sawada, Yuta Nakamatsu, Yutaka Mifune, Kenichiro Kakutani, Yuichi Hoshino, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Michiyo Koyanagi-Aoi, Takashi Aoi, Toshiyuki Takemori, Shunsuke Yahiro, Ryosuke Kuroda, Toshihiro Akisue

  Cancer stem cells (CSCs) have been implicated as critical mediators in the progression, chemoresistance and metastatic capabilities of diverse malignancies, including osteosarcoma (OS). The authors have succeeded in generating CSC‑like cells (MG‑OKS) from the OS cell line MG‑63 by transducing defined factors. A significant increase in small proline‑rich protein 1A (SPRR1A) expression, a cross‑linked envelope protein in keratinocytes, was observed in MG‑OKS cells. Therefore, SPRR1A could be involved in tumor initiation, growth and poor OS progression. However, its specific role in OS remains unclear. The present study aimed to evaluate the role of SPRR1A in OS both in vitro and in vivo using MG‑OKS cells. Three experimental groups were established: MG‑OKS cells transfected with SPRR1A small interfering (si)RNA (siMG‑OKS), untransfected MG‑OKS cells and MG‑OKS cells transfected with scrambled siRNA (scMG‑OKS) as controls. SPRR1A expression, morphological changes, cell proliferation and migration were assessed in these groups. RNA sequencing was performed to examine the genetic changes caused by SPRR1A suppression. To evaluate tumorigenicity in vivo, cells from each group were subcutaneously transplanted into the backs of nude mice. Tumor volume and Ki‑67 expression were assessed and compared among the three groups at four weeks post‑transplantation. The siMG‑OKS group exhibited altered cell morphology, reduced cell proliferation and decreased migratory abilities in vitro. RNA sequencing revealed suppression of genes involved in cell adhesion in the siMG‑OKS group. Furthermore, the in vivo tumorigenicity of siMG‑OKS was lower than that of the other two experimental groups. These findings suggest that SPRR1A is one of the key cell adhesion‑related molecules involved in OS progression, potentially serving as a therapeutic target for this refractory tumor. However, further research is needed to fully elucidate the mechanisms by which SPRR1A influences OS pathogenesis and to explore its clinical potential.

  Feb. 2025, Oncology reports, 53(2) (2), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The medullary cavity morphology of the proximal femur influences the fixation pattern of the rectangular tapered short stem in total hip arthroplasty.

  Yuma Onoi, Shinya Hayashi, Takaaki Fujishiro, Yuichi Kuroda, Naoki Nakano, Takafumi Hiranaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  INTRODUCTION: This study aimed to evaluate differences in the pattern of fixation with a rectangular tapered short stem (Fitmore stem) due to proximal femoral medullary cavity morphology based on periprosthetic bone mineral density (BMD) and radiological findings. MATERIALS AND METHODS: We analyzed 105 consecutive patients (Dorr type A, 18; Dorr type B, 66; Dorr type C, 21) who underwent total hip arthroplasty using a Fitmore stem. Periprosthetic BMD was measured using dual-energy X-ray absorptiometry from 1 to 24 months postoperatively and radiological analysis was performed. Clinical outcomes were evaluated using the Harris hip score (HHS) and the University of California Los Angeles (UCLA) activity score preoperatively and 24 months postoperatively. RESULTS: At 24 months postoperatively, Dorr type C had significantly decreased BMD changes in Gruen zones 2, 6, and 7 compared to Dorr types A and B, and conversely, significantly increased BMD changes in zone 4 (p < 0.05). Dorr type C had significantly greater subsidence than the other types (p < 0.01) and significantly higher cortical hypertrophy in zone 3 (p < 0.01). Stress shielding was not significantly different between Dorr types. The preoperative and postoperative HHS and UCLA activity scores showed no significant differences between the Dorr types. CONCLUSIONS: In Dorr type C, BMD significantly decreased in the proximal femur with a rectangular tapered short stem, suggesting that the stem was fixed at the distal part. Careful observation of this prosthesis over time is needed in patients with Dorr type C.

  Aug. 2024, Archives of orthopaedic and trauma surgery, 144(8) (8), 3857 - 3864, English, International magazine

  Scientific journal


• The assessment of canal flare index and proximal femoral bone density can improve stem selection for peri-prosthetic bone maintenance after total hip arthroplasty.

  Shinya Hayashi, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Masanori Tsubosaka, Shotaro Tachibana, Ryosuke Kuroda

  INTRODUCTION: Bone maintenance after total hip arthroplasty (THA) is important for implant success. This study aimed to investigate the relationship between patient characteristics and periprosthetic bone maintenance after THA for better implant selection. MATERIALS AND METHODS: This retrospective cohort study enrolled 112 consecutive patients who underwent THA using full hydroxyapatite (HA) compaction with short (n = 55) or short-tapered wedge (n = 61) stems. Periprosthetic bone mineral density (BMD) was compared between the two groups after propensity score matching, and the relationship between periprosthetic BMD changes and patient background was analyzed. RESULTS: Both groups showed similar periprosthetic BMD changes after adjusting for patient background using propensity score matching. Canal flare index > 3.7 in patients that underwent THA using tapered-wedge stem (odds ratio (OR), 3.2; 95% confidence interval (CI), 1.3-7.9, p = 0.013) and baseline zone 1 BMD > 0.65 in patients that received with short HA compaction stems (OR, 430.0; 95% CI 1.3-1420, p = 0.040) were associated with proximal periprosthetic bone maintenance after THA. CONCLUSION: Considering their predictive value, canal flare index and zone 1 BMD assessment might be useful strategies for implant selection during THA.

  May 2024, Archives of orthopaedic and trauma surgery, English, International magazine

  Scientific journal


• Influence of Distal Reference Point of the Tibial Mechanical Axis on the Ankle and Hindlimb Alignment Change after Total Knee Arthroplasty.

  Kenichi Kikuchi, Naoki Nakano, Kazunari Ishida, Yuichi Kuroda, Shinya Hayashi, Masanori Tsubosaka, Tomoyuki Kamenaga, Takehiko Matsushita, Ryosuke Kuroda, Tomoyuki Matsumoto

  The alignment philosophy in total knee arthroplasty (TKA) has tended to shift from the gold standard of mechanically aligned technique to personalized alignment, such as the kinematically aligned (KA) technique. However, the influences of different surgical techniques on lower limb alignment relative to the ground are not fully investigated. This study investigated the influence of the ankle and hindlimb alignment change after mechanically aligned TKA and KA-TKA. The varus osteoarthritic patients who underwent TKAs were divided into a mechanically aligned TKA group (group M, n = 50) and a KA-TKA group (group K, n = 50). Radiographic parameters (hip-knee-calcaneus [HKC] angle, hip-knee-ankle [HKA] angle, talar tilt angle [TTA], and tibiocalcaneal angle [TCA]) were investigated using full-length standing radiographs. The deviation angle (ΔTA; angle between the tibial mechanical axis [TMA] and the ground tibial mechanical axis [gTMA]) and the change of ΔTA (cΔTA) were also assessed. These parameters were compared between the two groups, along with the correlation between the preoperative HKA angle and other parameters. ΔTA, TTA, and TCA showed no differences between the groups pre- and postoperatively, and no significant changes were observed postoperatively. The preoperative HKA angle showed a significant negative correlation with cΔTA in both groups (group M: r = -0.33, p = 0.02; group K: r = -0.29, p = 0.04) although no correlation was observed the with preoperative TTA and TCA. Despite no change in ΔTA after surgery, the preoperative varus deformity was associated with a change in the deviation between gTMA and TMA after surgery. A severely varus knee may be inappropriate for ground KA-TKA.

  May 2024, The journal of knee surgery, 37(6) (6), 409 - 415, English, International magazine

  Scientific journal


• What effect does preoperative flexion contracture have on the component angles in unicompartmental knee arthroplasty?

  Naoki Nakano, Masanori Tsubosaka, Tomoyuki Kamenaga, Yuichi Kuroda, Kazunari Ishida, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: The indication for unicompartmental knee arthroplasty (UKA) has been extended to cases with some degree of preoperative knee flexion contracture recently. The purpose of this study was to clarify the effect of flexion contracture on component angles. MATERIALS AND METHODS: Thirty-five fixed-bearing UKAs using the spacer block technique with preoperative flexion contracture (Group FC) and 35 UKAs using the same technique without preoperative flexion contracture (Group NC) were included. Using radiographs, the coronal femoral component angle, coronal tibial component angle, sagittal femoral component angle, and sagittal tibial component angle were determined. Also, extension and flexion angles of the knee as well as coronal Hip-Knee-Ankle (HKA) angles in long-leg standing radiographs were measured. The data about the thickness of the selected insert were also collected. The above results were compared between the two groups. RESULTS: The femoral component tended to be placed in a more varus and flexed position in Group FC, while no significant difference was found about the tibial component angles. While there was no significant difference in pre- and postoperative knee flexion angles between the two groups, flexion contracture remained postoperatively in Group FC. Preoperative HKA angle was greater in Group FC while the difference was no longer significant postoperatively. Regarding the thickness of the selected insert, thicker inserts tended to be used in Group FC. CONCLUSIONS: In fixed-bearing UKA with the spacer block technique, the femoral component tended to be placed in a flexed and varus position in the knees with preoperative flexion contracture.

  May 2024, European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 34(4) (4), 2185 - 2191, English, International magazine

  Scientific journal


• Accuracy of portable navigation during THA in patients with severe developmental dysplasia of hip.

  Shinya Hayashi, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Masanori Tsubosaka, Ryosuke Kuroda

  INTRODUCTION: Correct cup placement in total hip arthroplasty (THA) for patients with developmental dysplasia of the hip (DDH) is considerably difficult. This study aimed to analyze the orientation accuracy of cup insertion during THA using a portable navigation system in patients with DDH. MATERIALS AND METHODS: In this retrospective cohort study, we analyzed data from 64 patients who underwent THA using infrared stereo camera-matching portable navigation. Patients underwent THA via the anterolateral approach in the lateral decubitus position. Navigation records for intraoperative cup angles, postoperative cup angles measured on computed tomography (CT) images, and cup angle measurement differences were measured and compared between patients with non-DDH/mild DDH and severe DDH. Furthermore, the predictive factors for outliers of accurate acetabular cup placement were analyzed. RESULTS: The average measurement absolute abduction differences (postoperative CT-navigation record) were 3.9 ± 3.5° (severe DDH) and 3.3 ± 2.6° (non-DDH/ mild DDH), and the anteversion differences were 4.7 ± 3.4° (severe DDH) and 2.3 ± 2.1° (non-DDH/ mild DDH). The anteversion difference was different between the two groups. Multivariate analysis showed that the navigation difference (absolute difference in anteversion between postoperative CT and navigation records of > 5°) was significantly associated with severe DDH (odds ratio [OR]: 3.3; p = 0.049, 95% confidence interval [CI]: 1.0-11.1) and posterior pelvic tilt (OR: 1.1; p = 0.042, 95% CI: 1.0-1.27). CONCLUSIONS: In patients with severe DDH, it is important to pay close attention during THA using portable navigation. However, the average difference was < 5º even in patients with severe DDH, and the accuracy may be acceptable in a clinical setting when the cost is considered.

  May 2024, Archives of orthopaedic and trauma surgery, 144(5) (5), 2429 - 2435, English, International magazine

  Scientific journal


• Predicting postoperative coronal alignment after fixed-bearing unicompartmental knee arthroplasty using a new morphological assessment method: the arithmetic hip-knee-ankle angle.

  Naoki Nakano, Masanori Tsubosaka, Tomoyuki Kamenaga, Yuichi Kuroda, Kazunari Ishida, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: Only a few reports have been published so far on factors that predict postoperative coronal alignment after unicompartmental knee arthroplasty (UKA). The purpose of this study is to clarify the relationship between the arithmetic hip-knee-ankle angle (aHKA) and postoperative coronal alignment after medial fixed-bearing UKA. METHODS: One hundred and one consecutive patients (125 knees) who underwent medial fixed-bearing UKA were assessed. Pre- and postoperative coronal HKA angles, lateral distal femoral angle (LDFA), medial proximal tibial angle (MPTA), and the thickness of the tibial and femoral bone cut were measured. aHKA was calculated as 180° - LDFA + MPTA. Correlations between postoperative HKA angle and aHKA, LDFA, and MPTA were investigated by single regression analysis. After the patients were divided into three groups according to the postoperative HKA angle, i.e., HKA angle > 180°, 175° < HKA angle ≤ 180°, and HKA angle ≤ 175°, aHKA, LDFA, MPTA, preoperative HKA angle, and the thickness of the distal femoral as well as tibial bone cut were compared among the three groups. RESULTS: aHKA and MPTA were positively correlated with postoperative HKA angle, while no correlation was found between postoperative HKA angle and LDFA. Among the three groups classified by postoperative HKA angle, significant differences were found in aHKA, MPTA, and preoperative HKA angle, while no significant difference was found in LDFA and the amount of distal femoral and tibial osteotomies. CONCLUSIONS: aHKA was correlated with postoperative HKA angle after medial fixed-bearing UKA, which was probably due to the influence of MPTA.

  Apr. 2024, International orthopaedics, 48(4) (4), 889 - 897, English, International magazine

  Scientific journal


• Mid- to Long-Term Results of Total Knee Arthroplasty for Charcot Arthropathy of the Knee.

  Yuma Onoi, Tomoyuki Matsumoto, Naoki Nakano, Masanori Tsubosaka, Tomoyuki Kamenaga, Yuichi Kuroda, Kazunari Ishida, Shinya Hayashi, Ryosuke Kuroda

  BACKGROUND: Total knee arthroplasty (TKA) for Charcot arthropathy of the knee is considered controversial because of its higher complication rate compared with that of TKA for osteoarthritis. In this study, we investigated the clinical outcomes, survival rates, and complications of primary TKA for Charcot arthropathy. METHODS: We conducted a retrospective analysis of nine patients (12 knees) with Charcot arthropathy who underwent TKA. The mean age of the patients was 63.9 ± 9.4 years (range, 52-83 years). The most frequent causative disease was diabetes mellitus (three patients). Patients' clinical outcomes, including the 2011 Knee Society Score and the range of motion, were compared between preoperative and the most recent postoperative data. The 5- and 10-year survival rates for aseptic revision, revision due to infection, and complications were examined. The mean follow-up period was 7.3 ± 3.9 years (range, 3-14 years). RESULTS: The 2011 Knee Society Score and the knee flexion angle significantly improved after TKA surgery (P < 0.05). The 5-year survival rates for aseptic revision, revision due to infection, and complications were 100%, 91.7%, and 83.3%, respectively; the 10-year survival rates for these parameters were the same. One patient underwent revision for insert replacement due to periprosthetic infection, and the other patient had varus/valgus instability due to soft tissue loosening. CONCLUSIONS: The mid- to long-term results of TKA for Charcot arthropathy were generally favorable. Our findings indicate that TKA may be a viable treatment option for Charcot arthropathy.

  Mar. 2024, Indian journal of orthopaedics, 58(3) (3), 308 - 315, English, International magazine

  Scientific journal


• LIGHT regulated gene expression in rheumatoid synovial fibroblasts.

  Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Kenichi Kikuchi, Yoshinori Takashima, Tomoyuki Matsumoto, Ryosuke Kuroda

  BACKGROUND: Synovial hyperplasia caused by rheumatoid arthritis (RA), an autoimmune inflammatory disease, leads to the destruction of the articular cartilage and bone. A member of the tumor necrosis factor superfamily, Lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells (LIGHT) has been shown to correlate with the pathogenesis of RA. METHODS: We used cDNA microarray analysis to compare the expression of genes in rheumatoid fibroblast-like synoviocytes with and without LIGHT stimulation. RESULTS: Significant changes in gene expression (P-values < 0.05 and fold change ≥ 2.0) were associated mainly with biological function categories of glycoprotein, glycosylation site as N-linked, plasma membrane part, integral to plasma membrane, intrinsic to plasma membrane, signal, plasma membrane, signal peptide, alternative splicing, and topological domain as extracellular. CONCLUSIONS: Our results indicate that LIGHT may regulate the expression in RA-FLS of genes which are important in the differentiation of several cell types and in cellular functions.

  Feb. 2024, Molecular biology reports, 51(1) (1), 356 - 356, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The severity of preoperative varus deformity affects the feasibility of correcting lower limb alignment with medial unicompartmental knee arthroplasty.

  Naoki Nakano, Yuichi Kuroda, Toshihisa Maeda, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Yuichi Hoshino, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: The relationship between the severity of preoperative varus deformity and the amount of its correction in unicompartmental knee arthroplasty (UKA) as well as the thickness of the insert has not been well known. METHODS: One hundred and three patients who underwent medial fixed-bearing UKA with the use of the spacer block method were assessed. After the component gap in extension was measured using a UKA tensor, the pre-osteotomy gap was calculated from the thickness of the bone cuts. The relationship between the preoperative hip-knee-ankle (HKA) angle as well as the pre-osteotomy gap and the amount of change in HKA angle were analysed. Also, preoperative HKA angle and the thickness of the bone cuts were compared among groups by the insert thickness. RESULTS: The mean preoperative HKA angle was 7.7 ± 3.1° varus. Patients with more varus deformity and those with a wider pre-osteotomy gap showed a more valgus change in HKA angle. As for the thickness of the insert, the preoperative HKA angle of the patients with the thinnest insert was significantly smaller (less varus) than that of those with the thicker insert while no statistically significant difference was found among the insert groups regarding the amount of the bone cuts. CONCLUSIONS: The severity of the preoperative varus deformity as well as the intraoperative pre-osteotomy gap related to the amount of change in HKA angle. As thick inserts tended to be used in severe varus knees, the tibial bone cut can be reduced in such cases.

  Jan. 2024, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 29(1) (1), 183 - 187, English, Domestic magazine

  Scientific journal


• Krüppel-like factor 15 deficiency exacerbates osteoarthritis through reduced expression of peroxisome proliferator-activated receptor gamma signaling in mice.

  Kemmei Ikuta, Shinya Hayashi, Kenichi Kikuchi, Masahiro Fujita, Kensuke Anjiki, Yuma Onoi, Shotaro Tachibana, Yoshihito Suda, Kensuke Wada, Yuichi Kuroda, Naoki Nakano, Toshihisa Maeda, Tomoyuki Matsumoto, Tetsuya Hosooka, Wataru Ogawa, Ryosuke Kuroda

  OBJECTIVE: Krüppel-like zinc finger transcription factors (KLFs) play diverse roles in mammalian cell differentiation and development. In this study, we investigated the function of KLF15 in the progression of osteoarthritis (OA). METHODS: 0Destabilization of the medial meniscus (DMM) surgery was performed in 10-week-old male wild-type control (WT) mice and cartilage-specific KLF15 knockout (KO) mice. Histological analysis, immunohistochemistry, and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling staining were performed. Morphological changes were measured using microcomputed tomography. Six mice from each group were analyzed (total number of mice analyzed: 60). In vitro, immunofluorescence, quantitative reverse transcription-polymerase chain reaction, and western blot analyses were performed. RESULTS: KLF15 KO DMM mice exhibited significant cartilage degradation compared to WT mice. According to the Osteoarthritis Research Society International cartilage OA-histopathology scoring system, the mean sum score in KLF15 KO mice was significantly higher than that in WT mice at 8 weeks after surgery. Immunohistochemistry results revealed KLF15 KO mice exhibited reduced peroxisome proliferator-activated receptor gamma (PPARγ) expression, increased pIKKα/β, a disintegrin-like and metalloproteinase with thrombospondin motifs (ADAMTS) 5, and Matrix metalloproteinases (MMP13) expression, and reduced Forkhead box O (FOXO1) and Light chain 3B (LC3B) expression. Inhibition of PPARγ phosphorylation accelerated the effects of interleukin (IL) 1β-treatment in both KLF15 KO and WT chondrocytes, and activation of PPARγ expression canceled the IL1β-induced catabolic effects. CONCLUSION: Our results indicated that the OA phenotype of KLF15 KO DMM mice was influenced by reduced PPARγ expression, including enhanced pIKKα/β, ADAMTS5, and MMP13 expression, reduced autophagy, and increased apoptosis. KLF15 regulation may constitute a possible therapeutic strategy for the treating OA.

  Jan. 2024, Osteoarthritis and cartilage, 32(1) (1), 28 - 40, English, International magazine

  Scientific journal


• Clinical use of autologous adipose-derived stromal vascular fraction cell injections for hip osteoarthritis.

  Yuma Onoi, Tomoyuki Matsumoto, Satoshi Sobajima, Masanori Tsubosaka, Shinya Hayashi, Takehiko Matsushita, Hideki Iwaguro, Ryosuke Kuroda

  INTRODUCTION: Currently, studies on adipose-derived stromal vascular fraction (SVF) cells are attracting increasing attention because they have the potential to differentiate into a subset of cell types, such as bone marrow-derived mesenchymal stromal cells (MSCs), and are easier to harvest than MSCs, thus making them easier to apply clinically. This study evaluated the short-term clinical outcomes of SVF cell therapy for hip osteoarthritis (OA). METHODS: Forty-two patients were enrolled in this study; these patients received a single injection comprising an average of 3.8 (standard deviation [SD], ±1.3) × 107 SVF cells into the hip joint. All patients were followed-up for at least 6 months. The mean age of the patients was 60.2 years (SD, ±9.4 years). Kellgren-Lawrence (KL) grades II, III, and IV based on radiography were 13, 13, and 16 patients, respectively. SVF cells were obtained from the subcutaneous fat of the abdomen or breech using a Celution® 800/CRS system. The average cell viability of SVF cells was 90.8% (SD, ±2.8%). Clinical assessments were performed using the Harris Hip Score (HHS), Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) score, and visual analog scale (VAS) score to evaluate pain. Images were evaluated using radiography, and T2 mapping values were obtained using a 1.5-T magnetic resonance imaging system. These clinical and imaging assessments were followed from preoperatively to 6 months postoperatively. RESULTS: The HHS, JHEQ score, and VAS score improved significantly from 22.5 (SD, ±16.6), 26.6 (SD, ±11.3), and 75.5 (SD, ±15.8) preoperatively to 46.8 (SD, ±27.2), 39.4 (SD, ±19.7), and 46.5 (SD, ±27.9), respectively, at 6 months postoperatively. KL grade II showed significant improvement in clinical outcome from preoperative to postoperative, while KL grade IV showed slight or little improvement. The center edge angle, acetabular head index on the radiographs, and T2 mapping values did not change significantly from preoperatively to 6 months postoperatively. CONCLUSIONS: SVF cell injection in the hip joint showed good short-term clinical efficacy for reducing hip OA symptoms. SVF cell therapy is thus an innovative and effective treatment for hip OA.

  Dec. 2023, Regenerative therapy, 24, 94 - 102, English, International magazine

  Scientific journal


• Accuracy comparison of cup positioning during total hip arthroplasty using Hip Align and AR-Hip in the supine position.

  Masahiro Fujita, Shinya Hayashi, Yuichi Kuroda, Naoki Nakano, Toshihisa Maeda, Takehiko Matsushita, Tomoyuki Matsumoto, Ryosuke Kuroda

  INTRODUCTION: The aim of this study is to compare the accuracy of acetabular cup positioning between the accelerometer-based navigation system and the augmented reality-based navigation system during THA in the supine position. MATERIALS AND METHODS: This retrospective study included 66 patients (70 hips) who underwent THA using two types of portable navigation system, Hip Align or AR-Hip, in the spine position. The absolute difference between the intraoperative navigation record and postoperative measurement using computed tomography data was evaluated. Preoperative clinical factors that decreased the accuracy of cup positioning by ≥ 3° were analyzed via multiple logistic regression analyses. RESULTS: The average absolute error of inclination was 2.8 ± 2.6° in Hip Align and 2.7 ± 1.8° in AR-Hip, and absolute anteversion error was 2.5 ± 2.0° in Hip Align and 2.6 ± 2.2° in AR-Hip, and there was no significantly different between the two navigation systems. There was a significant association between the absolute measurement error (≥ 3°) of cup inclination and patients' BMI in the Hip Align group [odds ratio (OR) 1.350; 95% confidence interval (CI) 1.035-1.760; p = 0.027], but not in the AR-Hip group. CONCLUSIONS: The accuracy of the acetabular cup positioning between the Hip Align and AR-Hip showed no difference during THA in the spine position. The high BMI could have negative influence on the accuracy of cup positioning in THA using Hip Align, thus AR-Hip could be designable for obesity patients.

  Dec. 2023, Archives of orthopaedic and trauma surgery, 143(12) (12), 7229 - 7235, English, International magazine

  Scientific journal


• Successful Total Knee Arthroplasty for Hoffa and Proximal Tibial Fractures: Report of Three Complex Cases After Failed Osteosynthesis Procedures.

  Takuma Maeda, Tomoyuki Matsumoto, Masahiro Fujita, Masanori Tsubosaka, Tomoyuki Kamenaga, Naoki Nakano, Yuichi Kuroda, Shinya Hayashi, Takahiro Niikura, Ryosuke Kuroda

  BACKGROUND Distal femoral and proximal tibial fractures often lead to nonunion and post-traumatic osteoarthritis, and total knee arthroplasty (TKA) has emerged as an effective alternative for older patients. This report includes 3 cases of successful TKA treatment. The cases involve a 42-year-old man and a 62-year-old man with Hoffa coronal fractures of the distal femur, and a 50-year-old man with a proximal tibial fracture. These patients underwent multiple osteosynthesis procedures before receiving TKA. CASE REPORT Case 1: A 42-year-old man with a displaced Hoffa's fracture had persistent knee pain. Nonunion post-initial fixation led to reoperation with iliac bone grafting and plate fixation. TKA using a Posterior Stabilized (PS)-type implant resulted in improved motion and function after 3 years. Case 2: A 62-year-old man suffered lateral condyle and ligament injuries from a displaced Hoffa's fracture. Despite plate fixation, dislocation occurred, requiring conversion. TKA with long-stem hinge-type implant, using augmentation block, led to enhanced stability and outcomes at 2 years. Case 3: A 50-year-old man's tibial nonunion, treated with plate fixation, resulted in infection and bone fusion. TKA using a constrained PS-type implant insert addressed the lateral tibial adhesions via iliotibial band (ITB) release and treated severe tibial plateau damage. Positive results were seen at 1 year. CONCLUSIONS The challenges of pseudarthrosis, like bone defects and compromised tissue, highlight the need for precise implant selection based on evaluations of bone quality, defects, knee stability, and hyperextension, rather than resorting to overly-constrained implants.

  Nov. 2023, The American journal of case reports, 24, e941187, English, International magazine

  Scientific journal


• Comparison study of periprosthetic bone remodeling between simultaneous bilateral total hip arthroplasty and unilateral total hip arthroplasty: a matched cohort study.

  Shinya Hayashi, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Shotaro Tachibana, Ryosuke Kuroda

  PURPOSE: The load-bearing pattern of periprosthetic bone may differ between patients who underwent simultaneous bilateral and unilateral total hip arthroplasty (THA). We investigated the differences in periprosthetic bone remodeling after simultaneous bilateral total hip arthroplasty and unilateral total hip arthroplasty. METHODS: This retrospective cohort study enrolled 154 consecutive patients undergoing THA using full hydroxyapatite (HA) compaction short stems. Patient characteristics including age, body mass index, University of California Los Angeles (UCLA) activity score, and bone shape of the proximal femur were adjusted by propensity score matching. Subsequently, periprosthetic bone mineral density changes were compared between simultaneous bilateral and unilateral THA. RESULTS: We found that bone mineral density loss in the simultaneous bilateral THA group was significantly higher in zones 6 and 7 at 24 months after THA (zone 6, p = 0.019; zone 7, p = 0.041). Periprosthetic bone mineral density loss was not associated with clinical factors, including age, body mass index, and daily activity. Additionally, we demonstrated that periprosthetic bone mineral density loss was higher in zones 1, 4, 6, and 7 of patients with a normal hip on the contralateral side after unilateral THA (zone 1, p = 0.041; zone 4, p = 0.041; zone 6, p = 0.037; zone7, p = 0.019). CONCLUSIONS: The postoperative periprosthetic bone remodeling was lower in patients who underwent simultaneous bilateral THA than in those who underwent unilateral THA, even though patient characteristics were adjusted by propensity matching. Further observation of periprosthetic bone mineral density loss is needed to clarify the differences between the groups.

  Nov. 2023, International orthopaedics, 47(11) (11), 2767 - 2772, English, International magazine

  Scientific journal


• Pseudarthrosis of Pelvic Fracture With Charcot Arthropathy Successfully Treated With Constrained Total Hip Arthroplasty.

  Toshiki Kitamura, Shinya Hayashi, Tomoyuki Matsumoto, Shingo Hashimoto, Naoki Nakano, Yuichi Kuroda, Takahiro Niikura, Ryosuke Kuroda

  Charcot arthropathy is a rapidly progressive and destructive form of arthropathy caused by various neurological diseases. Total hip arthroplasty (THA) is usually contraindicated in patients with Charcot arthropathy; however, recent studies have reported good results following THA in this patient population. Herein, we report a case of Charcot arthropathy secondary to syphilis in a patient who was successfully treated with constrained THA, a new type of THA. A 56-year-old man was injured in a car accident, and a displaced acetabular fracture was revealed three weeks later. He was treated conservatively but soon developed greater displacement of the fracture and femoral head destruction. The patient was referred to our hospital for further treatment. The patient had pelvic pseudarthrosis secondary to Charcot arthropathy at the time of the first visit to our hospital. First, THA was performed with the acetabular reconstruction of the deficient bone. However, the acetabular implant was displaced one week postoperatively. THA revision was performed using a constrained cup. Postoperatively, the patient exhibited good hip stability without dislocation. However, displacement of the acetabular cup occurred one year after the second surgery. We performed a re-revision of THA using a new type of constrained cup that offers a high level of constraint to maintain range of motion (ROM) and prevent dislocations. The patient was able to walk with a T-cane one year postoperatively. Herein, we report a difficult case of revision THA in a patient with Charcot arthropathy concomitant with syphilis. THA is usually contraindicated in patients with Charcot arthropathy; however, we propose that THA using constrained cups that offer a wider ROM may be a useful therapeutic strategy for the treatment of Charcot arthropathy.

  Nov. 2023, Cureus, 15(11) (11), e48295, English, International magazine


• Heterogeneous Cells as well as Adipose-Derived Stromal Cells in Stromal Vascular Fraction Contribute to Enhance Anabolic and Inhibit Catabolic Factors in Osteoarthritis.

  Kensuke Anjiki, Tomoyuki Matsumoto, Yuichi Kuroda, Masahiro Fujita, Shinya Hayashi, Naoki Nakano, Masanori Tsubosaka, Tomoyuki Kamenaga, Yoshinori Takashima, Kenichi Kikuchi, Kenmei Ikuta, Yuma Onoi, Shotaro Tachibana, Yoshihito Suda, Kensuke Wada, Takehiko Matsushita, Ryosuke Kuroda

  The stromal-vascular fraction (SVF), comprising heterogeneous cell populations and adipose-derived stromal cells (ADSCs), has therapeutic potential against osteoarthritis (OA); however, the underlying mechanism remains elusive. This study aimed to investigate the therapeutic effects of heterogeneous cells in rabbit SVF on rabbit chondrocytes. Rabbit SVF and ADSCs were autografted into knees at OA onset. The SVF (1 × 105) and low-dose ADSCs (lADSC; 1 × 104) groups adjusted for their stromal cell content were compared. Animals were euthanized 8 and 12 weeks after OA onset for macroscopic and histological analyses of OA progression and synovitis. Immunohistochemical and real-time polymerase chain reaction assessments were conducted. In vitro, immune-fluorescent double staining was performed for SVF to stain macrophages with F4/80, CD86(M1), and CD163(M2). OA progression was markedly suppressed, and synovitis was reduced in the SVF groups (OARSI histological score 8 W: 6.8 ± 0.75 vs. 3.8 ± 0.75, p = 0.001; 12 W: 8.8 ± 0.4 vs. 5.4 ± 0.49, p = 0.0002). The SVF groups had higher expression of collagen II and SOX9 in cartilage and TGF-β and IL-10 in the synovium, lower expression of MMP-13, and lower macrophage M1/M2 ratio than the lADSC groups. Immunofluorescent double staining revealed a markedly higher number of M2 than that of M1 macrophages in the SVF. The therapeutic effects of SVF on chondrocytes were superior than those of lADSCs, with enhanced anabolic and inhibited catabolic factors. Heterogeneous cells, mainly M2 macrophages in the SVF, enhanced growth factor secretion and chondrocyte-protective cytokines, thus benefiting chondrocytes and knee joint homeostasis. Overall, the SVF is a safe, relatively simple, and a useful treatment option for OA.

  Oct. 2023, Stem cell reviews and reports, 19(7) (7), 2407 - 2419, English, International magazine

  Scientific journal


• Targeting the neutral hip-to-calcaneus axis in kinematically aligned total knee arthroplasty is feasible with fewer alignment outliers for varus osteoarthritic patients.

  Tomoyuki Matsumoto, Naoki Nakano, Kazunari Ishida, Toshihisa Maeda, Shotaro Tachibana, Yuichi Kuroda, Shinya Hayashi, Takehiko Matsushita, Ryosuke Kuroda

  PURPOSE: Assessment of the conventional mechanical axis (MA) (hip-to-talus axis) is reported to result in constitutional varus in the native knee. However, the ground MA (hip-to-calcaneus axis), which is the line from the hip center to the bottom of the calcaneus, passes through the center of the knee joint in the native knee and is a possible alternative target for total knee arthroplasty (TKA) assessments. Therefore, this study aimed to present a "ground kinematically aligned (KA)-TKA." In this technique, the femoral component is placed on the cylindrical axis using the calipered technique and the tibial component is placed to give a neutral ground MA. Radiographical investigation was used to determine whether physiological alignment can be individually achieved with ground KA-TKA; this was compared with that of a tibia-restricted modified KA-TKA, referring to conventional MA (hip-to-talus axis) results. METHODS: As the primary endpoint, this prospective cohort study compared the ground MA ratios of the knee joints in 40 ground KA-TKAs (G group: Coronal Plain Alignment of the Knee (CPAK) 28 type I, 7 II, 1 IV, and 4 V) with those of the preceding 60 modified KA-TKAs (M group: CPAK 46 type I, 12 II, and 2 V) performed for patients with varus osteoarthritis (OA). The number of outliers differing over ± 5% from the neutral were compared between groups using the χ2-test. The Hip-knee-ankle (HKA) angle, coronal femoral/tibial component alignment (FCA/TCA), and joint line orientation angle (JLOA) were compared between the groups using non-paired t-tests. Statistical significance was set at p < 0.05. RESULTS: The G group had a higher ratio of the ground MA passing through the knee center than the M group did; outliers differing over ± 5% from the neutral of the ground MA were 2/40 cases in the G group and 20/60 cases in the M group, which was a significant difference (p = 0.001). The HKA angle, FCA/TCA, and JLOA were not significantly different between the groups. CONCLUSIONS: Targeting the ground MA in KA-TKA for patients with varus OA was feasible and has the potential to provide a physiological alignment more similar to the native knee in TKA than other kinematic alignment techniques. LEVEL OF EVIDENCE: Level III.

  Sep. 2023, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 31(9) (9), 3880 - 3888, English, International magazine

  Scientific journal


• Ground kinematically aligned total knee arthroplasty: new personalized technique which enables a stable knee with deep flexion.

  Tomoyuki Matsumoto, Naoki Nakano, Kazunari Ishida, Yuichi Kuroda, Shinya Hayashi, Hirotsugu Muratsu, Ryosuke Kuroda

  PURPOSE: This study aimed to evaluate kinematically aligned total knee arthroplasty (KA-TKA) targeting the neutral ground mechanical axis (MA) (hip-to-calcaneus axis), the line from the hip centre to the bottom of the calcaneus, (ground KA-TKA) in terms of its comparison with tibia-restricted modified KA-TKA (modified KA-TKA). METHODS: This retrospective cohort study included 106 consecutive patients who underwent unilateral KA-TKA for varus osteoarthritis (OA) (60 modified KA-TKAs and 46 ground KA-TKAs). After 1:1 propensity score matching, 60 patients (30 pairs) were matched between the groups with comparable demographic data. The hip-knee-ankle (HKA) angle, coronal femoral component alignment (FCA), and coronal tibial component alignment (TCA) were compared between groups. Intraoperative soft tissue balance, including the joint component gap and varus/valgus balance, was also compared between the groups. One year postoperatively, the clinical outcomes, including the range of motion and 2011 Knee Society Score, were compared between groups. RESULTS: The HKA angle and FCA/TCA were not significantly different between groups. Whereas the varus/valgus balance showed no significant differences between groups, smaller joint component gaps were found throughout the range of motion in the ground KA-TKA group than in the modified KA-TKA group. Despite no difference in clinical scores between groups, a significantly deeper postoperative flexion angle was achieved in the ground KA-TKA group than in the modified KA-TKA group (p < 0.05). CONCLUSION: Targeting neutral ground MA in KA-TKA for patients with varus OA has the potential to provide a better flexion angle with stable intraoperative soft tissue balance.

  Sep. 2023, International orthopaedics, 47(9) (9), 2215 - 2223, English, International magazine

  Scientific journal


• Clinical Characteristics and Surgical Outcomes of Metastatic Spine Tumors in the Very Elderly: A Prospective Cohort Study in a Super-Aged Society.

  Yutaro Kanda, Kenichiro Kakutani, Yoshitada Sakai, Kunihiko Miyazaki, Tomoya Matsuo, Takashi Yurube, Yoshiki Takeoka, Hiroki Ohnishi, Masao Ryu, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Teruya Kawamoto, Hitomi Hara, Yuichi Hoshino, Shinya Hayashi, Toshihiro Akisue, Ryosuke Kuroda

  The number of advanced-age patients with spinal metastases is rising. This study was performed to clarify the characteristics and surgical outcomes of spinal metastases in advanced-age patients. We prospectively analyzed 216 patients with spinal metastases from 2015 to 2020 and divided them into three age groups: <70 years (n = 119), 70-79 years (n = 73), and ≥80 years (n = 24). Although there were no significant intergroup differences in preoperative characteristics and surgery-related factors except for age, patients aged ≥80 years tended to have a worse performance status (PS), Barthel index, and EuroQol-5 dimension (EQ-5D) before and after surgery than the other two groups. Although the median PS, mean Barthel index and mean EQ-5D greatly improved postoperatively in each group, the median PS and mean Barthel index at 6 months and the mean EQ-5D at 1 month postoperatively were significantly poorer in the ≥80-year group than the 70-79-year group. The rates of postoperative complications and re-deterioration of the EQ-5D were significantly higher in the oldest group than in the other two groups. Although surgery for spinal metastases improved the PS, Barthel index, and EQ-5D regardless of age, clinicians should be aware of the poorer outcomes and higher complication rates in advanced-age patients.

  Jul. 2023, Journal of clinical medicine, 12(14) (14), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Prosthetic orientation, limb alignment, and soft tissue balance with bi-cruciate stabilized total knee arthroplasty: a comparison between the handheld robot and conventional techniques.

  Tomoyuki Matsumoto, Naoki Nakano, Shinya Hayashi, Koji Takayama, Toshihisa Maeda, Kazunari Ishida, Yuichi Kuroda, Takehiko Matsushita, Takahiro Niikura, Hirotsugu Muratsu, Ryosuke Kuroda

  PURPOSE: This study aimed to examine the prosthetic orientations, limb alignment, intraoperative soft tissue balance, and early clinical outcomes associated with the use of the relatively new handheld robot technique compared to those associated with the use of the conventional alignment guide for bi-cruciate stabilized total knee arthroplasty (TKA). METHODS: This retrospective cohort study compared the prosthetic orientation and limb alignment of 35 patients who underwent TKA using robotic assistance (robot group) with those of patients who underwent TKA using a conventional alignment guide (control group). The coronal femoral component alignment (FCA), coronal tibial component alignment (TCA), and the hip-knee-ankle (HKA) angle were compared between groups. Intraoperative soft tissue balance, including the joint component gap and varus/valgus balance assessed by an offset-type tensor, were also compared between groups. One year postoperatively, the clinical outcomes, including the range of motion and 2011 Knee Society Score (KSS), were compared between groups. RESULTS: The HKA angle and FCA were 0.1° varus and 0.1° varus, respectively, in the robot group and 1.3° varus and 1.3° varus, respectively, in the control group. The difference in the HKA angle and the FCA, but not the TCA, between groups was statistically significant (p < 0.05). The intraoperative soft tissue balance showed more stable joint component gaps and varus/valgus balances throughout the range of motion in the robot group than in the control group. Clinical outcomes of the robot group showed superior 2011 KSS subscales compared to those of the control group. CONCLUSION: The accuracy of the implantations and stable soft tissue balance in the robot group were superior to those of the control group. The robot group also had superior patient-reported scores for early clinical outcomes.

  Jun. 2023, International orthopaedics, 47(6) (6), 1473 - 1480, English, International magazine

  Scientific journal


• Acute Deterioration of Patient with Sudden Onset of Shock Caused by Group G Streptococcus Infection after Revision Total Knee Arthroplasty: A Case Report.

  Kensuke Wada, Tomoyuki Matsumoto, Kemmei Ikuta, Masanori Tsubosaka, Naoki Nakano, Toshihisa Maeda, Yuichi Kuroda, Shinya Hayashi, Ryosuke Kuroda

  BACKGROUND Periprosthetic joint infection is a difficult complication, especially in patients with rheumatoid arthritis. Life-threatening septic shock due to periprosthetic joint infection caused by group G streptococcus is rare, and there have been few reports about its treatment. We describe a successful case of sudden onset septic shock due to group G Streptococcus infection after revision total knee arthroplasty. CASE REPORT A 61-year-old woman with rheumatoid arthritis treated with biological disease-modifying antirheumatic drugs for about 12 years presented with acute right knee pain and shock 6 months after revision total knee arthroplasty. Periprosthetic joint infection caused by group G Streptococcus was diagnosed. She was admitted to the Intensive Care Unit, treated with respiratory support and dialysis, and underwent irrigation, debridement, and polyethylene liner exchange as the first surgery. At 9 days after the first surgery, she underwent the second surgery, consisting of implant removal and antibiotic spacer placement due to failure. It took approximately 7 weeks to normalize the levels of systemic markers of inflammation with intravenous antibiotics and then oral antibiotics for further 12 weeks, but re-revision total knee arthroplasty was successfully performed 1.5 years later. At a 1-year follow-up from the final surgery, she was able to walk with a cane and had no symptoms of infection. CONCLUSIONS In such cases with sudden onset of septic shock due to periprosthetic joint infection, appropriate and prompt surgical treatment should be performed to save the infected limb as well as the patient's life.

  Apr. 2023, The American journal of case reports, 24, e938905, English, International magazine

  Scientific journal


• Effect of low-intensity pulsed ultrasound on osteogenic differentiation of human induced membrane-derived cells in Masquelet technique.

  Kyohei Takase, Tomoaki Fukui, Keisuke Oe, Kenichi Sawauchi, Ryo Yoshikawa, Yuya Yamamoto, Shinya Hayashi, Tomoyuki Matsumoto, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: The Masquelet technique is a relatively new method for large bone defect treatment. In this technique, grafted bone tissue is used, and after the cement is removed, the induced membrane (IM; that form around the cement spacers placed in the bone defect region) is thought to play an important role in promoting bone formation. On the other hand, low-intensity pulsed ultrasound (LIPUS) is known to promote fracture healing and angiogenesis through mechanical stimulation. This study aimed to investigate the in vitro effects of LIPUS on the osteogenic differentiation of human induced membrane-derived cells (IMCs). METHODS: Seven patients who had been treated using the Masquelet technique were enrolled. The IM was harvested during the second stage of the technique. IMCs were isolated, cultured in growth medium, and then divided into two groups: (1) control group, IMCs cultured in osteogenic medium without LIPUS, and (2) LIPUS group, IMCs cultured in osteogenic medium with LIPUS treatment. Adherent cells from the IM samples were harvested after the first passage and evaluated for cell surface protein expression using immunostaining. A cell proliferation assay was used to count the number of IMCs using a hemocytometer. Osteogenic differentiation capability was assessed using an alkaline phosphatase (ALP) activity assay, Alizarin Red S staining, and real-time reverse transcription-polymerase chain reaction. RESULTS: Cell surface antigen profiling revealed that the IMCs contained cells positive for the mesenchymal stem cell-related markers CD73, CD90, and CD105. No significant difference in cell numbers was found between the control and LIPUS groups. The ALP activity of IMCs in the LIPUS group was significantly higher than that in the control group on days 7 and 14. Alizarin red S staining intensity was significantly higher in the LIPUS group than in the control group on day 21. Runx2 and VEGF expression was significantly upregulated on days 7 and 14, respectively, compared with levels in the control group. CONCLUSION: We demonstrated the significant effect of LIPUS on the osteogenic differentiation of human IMCs. This study indicates that LIPUS can be used as an additional tool for the enhancement of the healing process of the Masquelet technique.

  Apr. 2023, Injury, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 【人工関節における進歩】手術支援技術 ナビゲーション 簡易ナビゲーション 人工股関節全置換術における簡易ナビゲーションの有用性

  林 申也, 黒田, 雄一, 中野 直樹, 松本 知之, 黒田 良祐

  Apr. 2023, 別冊整形外科, (83) (83), 139 - 142, Japanese


• 発育性股関節形成不全と無症候性股関節の放射線画像における骨形態の比較検討

  立花 章太郎, 黒田 雄一, 齊藤 昌愛, 林 申也, 藤田 雅広, 菊池 健一, 生田 健明, 安喰 健祐, 尾ノ井 勇磨, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(2) (2), S113 - S113, Japanese


• 疫学1:RA/関節型JIAの治療 高齢関節リウマチ患者における疾患活動性の年次変化に関する検討 関西多施設共同研究ANSWER Cohort study

  山田 啓貴, 神野 定男, 前田 俊恒, 林 申也, 山本 渉, 大西 輝, 鬼澤 秀夫, 武内 徹, 平松 ゆり, 沖田 康孝, 蛯名 耕介, 孫 瑛洙, 吉田 直史, 渡部 龍, 原 良太, 片山 昌紀, 山下 真依, 能瀬 洋子, 山本 譲, 岡野 隆一, 西村 啓佑, 上田 洋, 千藤 荘, 橋本 求, 黒田 良祐, 三枝 淳

  (一社)日本リウマチ学会, Mar. 2023, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 526 - 526, Japanese


• JAK阻害薬-2 JAK阻害薬4剤の有効性比較と有効性に影響を与える因子の探索 関西多施設ANSWERコホートによる解析

  林 申也, 前田 俊恒, 山下 真依, 白杉 郁, 山本 譲, 山田 啓貴, 岡野 隆一, 西村 啓佑, 上田 洋, 神野 定男, 三枝 淳, 山本 渉, 村田 浩一, 藤井 貴之, 秦 健一郎, 吉川 紋佳, 蛯名 耕介, 惠谷 悠紀, 吉田 直史, 安室 秀樹, 原 良太, 片山 昌紀, 橋本 求, 岡野 匡志, 立花 章太郎, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2023, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 551 - 551, Japanese


• 生物学的製剤 IL-6阻害薬は骨びらんによる関節破壊の進行を優位に抑制する

  林 申也, 松原 司, 前田 俊恒, 福田 康治, 舟橋 恵子, 橋本 麿和, 積山 賢, 立花 章太郎, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2023, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 603 - 603, Japanese


• JAK阻害薬-7 多剤耐性マーカーMDR1遺伝子がJAK阻害薬の治療効果に与える影響について

  尾ノ井 勇磨, 菊池 健一, 前田 俊恒, 林 申也, 安喰 健祐, 生田 健明, 立花 章太郎, 橋本 麿和, 積山 賢, 舟橋 恵子, 福田 康治, 黒田 良祐, 松原 司

  (一社)日本リウマチ学会, Mar. 2023, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 708 - 708, Japanese


• IL-6刺激下でのJAK阻害剤の血管新生抑制効果の比較検討

  安喰 健祐, 林 申也, 前田 俊恒, 菊池 健一, 藤田 雅広, 生田 健明, 尾ノ井 勇磨, 立花 章太郎, 福田 康治, 積山 賢, 橋本 麿和, 舟橋 恵子, 黒田 良祐, 松原 司

  (一社)日本リウマチ学会, Mar. 2023, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 774 - 774, Japanese


• RA患者由来線維芽細胞様滑膜細胞へのIL-6・TNFα刺激に対するJAK阻害剤の炎症抑制効果の比較検討

  生田 健明, 林 申也, 前田 俊恒, 菊池 健一, 藤田 雅広, 安喰 健祐, 尾ノ井 勇磨, 立花 章太郎, 福田 康治, 積山 賢, 橋本 麿和, 舟橋 恵子, 黒田 良祐, 松原 司

  (一社)日本リウマチ学会, Mar. 2023, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 873 - 873, Japanese


• 軟骨細胞へのIL-6刺激に対するJAK阻害剤の効果

  立花 章太郎, 林 申也, 前田 俊恒, 菊池 健一, 藤田 雅広, 安喰 健祐, 生田 健明, 尾ノ井 勇磨, 福田 康治, 積山 賢, 橋本 麿和, 舟橋 恵子, 黒田 良祐, 松原 司

  (一社)日本リウマチ学会, Mar. 2023, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 873 - 873, Japanese


• The Identification of Risk Factors for Symptomatic Spinal Metastasis Onset: A Prospective Cohort Study of 128 Asymptomatic Spinal Metastasis Patients.

  Kenichiro Kakutani, Yutaro Kanda, Takashi Yurube, Yoshiki Takeoka, Kunihiko Miyazaki, Hiroki Ohnishi, Tomoya Matsuo, Masao Ryu, Kohei Kuroshima, Naotoshi Kumagai, Yoshiaki Hiranaka, Shinya Hayashi, Yuichi Hoshino, Hitomi Hara, Yoshitada Sakai, Ryosuke Kuroda

  Background: Symptomatic spinal metastasis (SSM) decreases the activities of daily living (ADL) and quality of life of cancer patients. However, the risk factors for SSM onset remain unclear. This prospective cohort study aimed to statistically analyze the significant risk factors. Methods: From 2016 to 2018, 210 consecutive patients with spinal metastases were prospectively registered. Patients with SSM at the first consultation and those who were unable to be followed-up owing to poor general condition were excluded. The demographic factors (age, sex, primary cancer, performance status, and ADL), clinical factors (radiation therapy, chemotherapy, molecularly targeted drugs, and bone-modifying agents (BMAs)), and Spinal Neoplastic Instability Score (SINS) were evaluated. Multivariate analysis was performed to identify the risk factors for SSM onset. Furthermore, the threshold was calculated from the receiver operating characteristic curve using the Youden index. Results: Thirty-nine patients who presented with SSM at the first consultation and 43 patients who were unable to be followed-up owing to poor general condition were excluded. Finally, 128 asymptomatic patients were included. Thirty-seven patients (28.9%) developed SSM during the follow-up period. The total SINS (OR: 1.739; 95% CI: 1.345-2.250) was identified as the most significant factor. The cut-off value of the SINS was 9.5 (sensitivity: 67.6%; specificity: 83.5%). Twenty-five (62.5%) of the forty patients with a SINS ≥ 10 developed SSM within a mean of 5.5 months (95% CI: 1.17-9.83). Furthermore, all patients with a SINS ≥ 13 developed SSM (n = 5) within a mean of 1.37 months (95% CI: 0.0-3.01). Conclusions: This study identified the significant risk factors for SSM onset and the threshold of the SINS. If long-term survival is expected, patients with a SINS ≥ 10 should be considered for intervention to prevent SSM.

  Feb. 2023, Cancers, 15(4) (4), English, International magazine

  Scientific journal


• Total knee arthroplasty for severe valgus deformity of the knee with extra-articular deformities of the femur and tibia using a 3-dimensional image matching software system.

  Kemmei Ikuta, Tomoyuki Matsumoto, Naoki Nakano, Shintaro Mukohara, Shinya Hayashi, Ryosuke Kuroda

  INTRODUCTION AND IMPORTANCE: Knee osteoarthritis with femoral and/or tibial extra-articular deformities makes total knee arthroplasty (TKA) technically difficult to perform, especially using intramedullary-based instrumentation systems. The Athena Knee 3-dimensional (3-D) image matching software is effective for TKA with an extra-articular deformity, especially in case of using a long-stem prosthesis or not available computer-assisted navigation systems. CASE PRESENTATION: A 79-year-old woman presented with right knee pain secondary to a progressive valgus deformity and gait disturbance. She had experienced a supracondylar femoral fracture fifteen years ago, and a tibial shaft fracture ten years ago on the same side; both of fractures were treated surgically. She had a severe valgus knee deformity and extra-articular deformity of femur and tibia, and valgus stress test detected medial knee instability. The range of motion was 0° in extension and 75° in flexion. Severe medial knee laxity compelled us to use a constrained and long-stem prosthesis, resulting in the use of an intramedullary guided system. The 3-D software system helped us to determine the amount of bone to cut as well as the appropriate entry points for the intramedullary rods and mechanical axis restoration. At two years after surgery, knee range of motion improved to 90° in flexion, and walking ability had also advanced from the use of two crutches to that of a T cane. CONCLUSION: The 3-D image matching software system for preoperative planning was useful for TKA with extra-articular deformity, especially in the case of a long-stem prosthesis without using a navigation system.

  Feb. 2023, International journal of surgery case reports, 103, 107853 - 107853, English, International magazine


• Identification and characterization of slow‑cycling cells in Ewing sarcoma.

  Shunsuke Yahiro, Teruya Kawamoto, Shuichi Fujiwara, Hitomi Hara, Naomasa Fukase, Ryoko Sawada, Toshiyuki Takemori, Tomohiro Miyamoto, Yutaka Mifune, Kenichiro Kakutani, Yuichi Hoshino, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Michiyo Koyanagi-Aoi, Takashi Aoi, Ryosuke Kuroda, Toshihiro Akisue

  Ewing sarcoma (ES) is an aggressive primary malignant bone tumor that predominantly affects children and young adults. Multimodal treatment approaches have markedly improved the survival of patients with localized ES. However, local recurrence and distant metastasis following curative therapies remain a main concern for patients with ES. Recent studies have suggested that slow‑cycling cells (SCCs) are associated with tumor progression, local recurrence and distant metastasis in various types of cancers. According to the results of these studies, it was hypothesized that SCCs may play a critical role in tumor progression, chemoresistance and local/distal recurrence in patients with ES. The present study applied a label‑retaining system using carboxyfluorescein diacetate succinimidyl ester (CFSE) to identify and isolate SCCs in ES cell lines. In addition, the properties of SCCs, including sphere formation ability, cell cycle distribution and chemoresistance, in comparison with non‑SCCs were investigated. RNA sequencing also revealed several upregulated genes in SCCs as compared with non‑SCCs; the identified genes not only inhibited cell cycle progression, but also promoted the malignant properties of SCCs. On the whole, the present study successfully identified SCCs in ES cells through a label‑retaining system using CFSE. Moreover, to the best of our knowledge, the present study is the first to describe the characteristic properties of SCCs in ES. The findings of this study, if confirmed, may prove to be useful in elucidating the underlying molecular mechanisms and identifying effective therapeutic targets for ES.

  Nov. 2022, International journal of oncology, 61(5) (5), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Polyarthritis presented in a patient with untreated chronic hepatitis B infection

  Kenichi Kikuchi, Koji Fukuda, Shinya Hayashi, Toshihisa Maeda, Yoshinori Takashima, Masahiro Fujita, Kenmei Ikuta, Kensuke Anjiki, Shotaro Tachibana, Yuma Onoi, Tomoyuki Matsumoto, Ryosuke Kuroda, Tsukasa Matsubara

  ABSTRACT Hepatitis B virus (HBV) infection can cause arthritis, but it is rarely reported. In the current report, we present a case of chronic polyarthritis in a patient with untreated HBV infection. A 63-year-old woman suffering from polyarthritis in her fingers visited our institution. She had experienced exacerbations and remissions of polyarthritis for more than 20 years. She had been diagnosed with rheumatoid arthritis and had been treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and nonsteroidal anti-inflammatory drugs by her primary care doctor, but the csDMARDs were discontinued at the request of the patient 10 years before the first visit to our hospital. The blood test showed negative for rheumatoid factor and anticyclic citrullinated peptides antibody but positive for hepatitis B surface antigen. Hepatitis B surface antigen and HBV-Deoxyribo Nucleic Acid (DNA) were increased to 312.6 (IU/ml) and 4.6 (log copies/ml), respectively. Based on the results of abdominal computed tomography and echography, she was diagnosed with liver cirrhosis. Treatment for HBV infection was begun with oral tenofovir at 25 mg/day. The polyarthritis in her fingers gradually disappeared and has not relapsed for 6 months after the initiation of treatment for HBV infection. When polyarthritis is diagnosed, the possibility that chronic HBV infection can be one of the causes of polyarthritis should be considered.

  Oxford University Press (OUP), Oct. 2022, Modern Rheumatology Case Reports, 7(1) (1), 320 - 323

  Scientific journal


• Effects of Femoral Component Design on the Deepest Point Position of the Trochlear Grove in Kinematically Aligned Total Knee Arthroplasty: A Comparison of Four Prothesis Designs

  Yoshinori Takashima, Naoki Nakano, Kazunari Ishida, Tomoyuki Kamenaga, Masanori Tsubosaka, Yuichi Kuroda, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  Abstract The aim of the study is to explore and compare the differences in trochlear shape and knee anatomy between four types of prostheses and preoperative native knee matched with preoperative computed tomography (CT). Thirty patients were scheduled for primary kinematically aligned total knee arthroplasty (TKA) for varus knee osteoarthritis at our hospital and the region between their pelvis to ankle joint was simulated using a CT-based three-dimensional planning software. The axial plane containing the transepicondylar axis was set as Slice A, and the 10-mm distal plane from Slice A was set as Slice B. The distances to the deepest trochlear groove between the native knee and each prosthesis and the medial and lateral facet heights were compared among the four groups. The deepest femoral trochlear groove of the prostheses was located 1.6 to 3.0 mm more medial than that of the native knee, and in the Persona group, it was significantly more medial than in the e-motion or Triathlon groups on both Slices A and B. The native knee and the medial and lateral facet heights of the four prostheses on both Slices A and B were significantly lower than those of preoperative native knees when femoral prostheses were set in the kinematically aligned (KA)-TKA position. The deepest point of the trochlear groove of the Persona group was the most medial among the four prostheses studied, and the deepest points differed depending on the prosthesis design in KA-TKA. Thus, surgeons should carefully select the type of prostheses used in KA-TKA.

  Georg Thieme Verlag KG, Sep. 2022, The Journal of Knee Surgery, 36(13) (13), 1316 - 1322

  Scientific journal


• The influence of stem alignment on the bone mineral density around the Polarstem following total hip arthroplasty

  Masahiro Fujita, Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Ryosuke Kuroda, Tomoyuki Matsumoto

  Springer Science and Business Media LLC, Sep. 2022, Archives of Orthopaedic and Trauma Surgery, 143(6) (6), 3621 - 3627

  Scientific journal


• OASL rs10774580 SNP is associated with Herpes Zoster infection in rheumatoid arthritis.

  Marowa Hashimoto, Keiko Funahashi, Ken Tsumiyama, Yoshinori Takashima, Toshihisa Maeda, Koji Fukuda, Shinya Hayashi, Ryosuke Kuroda, Tsukasa Matsubara

  Sep. 2022, Rheumatology: Current Research, 12(5) (5), 1000312, English

  [Refereed]

  Scientific journal


• Paracrine effect of the stromal vascular fraction containing M2 macrophages on human chondrocytes through the Smad2/3 signaling pathway.

  Masahiro Fujita, Tomoyuki Matsumoto, Shinya Hayashi, Shingo Hashimoto, Naoki Nakano, Toshihisa Maeda, Yuichi Kuroda, Yoshinori Takashima, Kenichi Kikuchi, Kensuke Anjiki, Kemmei Ikuta, Yuma Onoi, Shotaro Tachibana, Takehiko Matsushita, Hideki Iwaguro, Satoshi Sobajima, Takafumi Hiranaka, Ryosuke Kuroda

  The adipose-derived stromal vascular fraction (SVF) is composed of a heterogeneous mix of adipose-derived stem cells (ADSCs), macrophages, pericytes, fibroblasts, blood, and other cells. Previous studies have found that the paracrine effects of SVF cells may be therapeutic, but their role in osteoarthritis treatment remains unclear. This study aimed to investigate the therapeutic effect of SVF cells on chondrocytes. Chondrocytes were seeded on culture plates alone (control) or cocultured with SVF or ADSCs on cell culture inserts. After 48 h of coculture, chondrocyte collagen II, tissue inhibitors of metalloproteinases-3 (TIMP-3), and matrix metalloproteinases-13 (MMP-13) messenger RNA (mRNA) expression levels were evaluated using reverse-transcription polymerase chain reaction, and the transforming growth factor-β (TGF-β) levels in the supernatant were measured using ELISA. Immunohistochemical staining and flow cytometry were used to evaluate the macrophages in the SVF. These macrophages were characterized according to phenotype using the F4/80, CD86, and CD163 markers. To determine whether the Smad2/3 signaling pathways were involved, the chondrocytes were pre-treated with a Smad2/3 phosphorylation inhibitor and stimulated with the SVF, and then Smad2/3 phosphorylation levels were analyzed using western blot. The mRNA expression levels of various paracrine factors and chondrocyte pellet size were also assessed. Collagen II and TIMP-3 expression were higher in the SVF group than in the ADSC group and controls, while MMP-13 expression was the highest in the ADSC group and the lowest in the controls. TGF-β levels in the SVF group were also elevated. Immunohistochemical staining and flow cytometry revealed that the macrophages in the SVF were of the anti-inflammatory phenotype. Western blot analysis showed that the SVF increased Smad2/3 phosphorylation, while Smad2/3 inhibitors decreased phosphorylation. Smad2/3 inhibitors also reduced the expression of various other paracrine factors and decreased chondrocyte pellet size. These findings suggested that the paracrine effect of heterogeneous cells, such as anti-inflammatory macrophages, in the SVF partly supports chondrocyte regeneration through TGF-β-induced Smad2/3 phosphorylation.

  Sep. 2022, Journal of cellular physiology, 237(9) (9), 3627 - 3639, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The Effect of Prosthesis Type on Intraoperative Soft-Tissue Balance and Clinical Outcomes in Modified Kinematically Aligned Cruciate-Retaining Total Knee Arthroplasty

  Tomoyuki Matsumoto, Naoki Nakano, Kazunari Ishida, Yoshinori Takashima, Toshihisa Maeda, Yuichi Kuroda, Shinya Hayashi, Tekehiko Matsushita, Takahiro Niikura, Hirotsugu Muratsu, Ryosuke Kuroda

  Abstract Introduction Kinematically aligned total knee arthroplasty (KA-TKA) has gained interest for achieving more favorable clinical outcomes than mechanically aligned TKA. One of the advantages of KA-TKA is reported to be an easy acquisition of intraoperative soft-tissue balance without excessive medial release for varus osteoarthritis. However, we hypothesized that the prosthesis type affects intraoperative soft-tissue balance even in the KA-TKA. The present study aimed to compare intraoperative soft-tissue balance and clinical outcomes of KA-TKAs using single-radius (SR) or multiradius (MR) prostheses. Materials and Methods Consecutive 70 cruciate-retaining modified KA-TKAs (31 SR and 39 MR) were performed in patients with varus-type osteoarthritis using a navigation system. Intraoperative soft-tissue balance including joint component gap and varus/valgus balance was measured with femoral component placement and patellofemoral joint reduction throughout the range of motion using offset-type tensor and compared between the two groups. Two years postoperatively, the range of motion and 2011 Knee Society Scores were compared between the two groups. Results and Conclusion Joint component gaps showed no significant differences between the two groups from 0 to 30 degrees of flexion. However, during 60 to 120 degrees of flexion, joint component gaps of SR group showed significantly larger values than those of MR group (p < 0.05). There were no significant differences in varus/valgus balance throughout the range of motion between the two groups. The postoperative clinical outcomes showed no significant differences between the two groups. Interpretation Despite no difference in clinical outcomes, joint component gap showed different patterns due to the prosthesis type in modified KA-TKAs.

  Georg Thieme Verlag KG, Jul. 2022, The Journal of Knee Surgery, 36(10) (10), 1013 - 1019

  Scientific journal


• The influence of ruptured scar pattern of human anterior cruciate ligament remnant tissue on tendon‐bone healing in vivo

  Yoshinori Takashima, Tomoyuki Matsumoto, Naoki Nakano, Tomoyuki Kamenaga, Yuichi Kuroda, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda

  Abstract The purpose of this study was to determine whether the transplantation of human cells from a non‐reattached injured anterior cruciate ligament (ACL) remnant could enhance tendon‐bone healing. Human ACL remnant tissue was classified into two groups based on the morphologic pattern as per Crain's classification: (1) non‐reattachment group (Crain Ⅳ) and (2) reattachment group (Crain Ⅰ–Ⅲ). Seventy‐five 10‐week‐old immunodeficient rats underwent ACL reconstruction followed by intracapsular administration of one of the following: (1) ACL‐derived cells from the non‐reattached remnant (non‐reattachment group) (n = 5), (2) ACL‐derived cells from the reattached tissue (reattachment group) (n = 5), or (3) phosphate‐buffered saline (PBS) only (PBS group) (n = 5). Histological (Weeks 2, 4, and 8), immunohistochemical (Week 2), radiographic (Weeks 0, 2, 4, and 8), and biomechanical (Week 8) assessments were performed. Histological evaluation showed high and early healing, induction of endochondral ossification‐like integration, and mature bone ingrowth at Week 4 in the non‐reattachment group. Microcomputed tomography at Week 4 showed that the tibial bone tunnels in the non‐reattachment group were significantly reduced compared to those in the reattachment and PBS groups. Moreover, biomechanical testing showed that ultimate load‐to‐failure in the non‐reattachment group tended to be larger than that in the reattachment group, though not statistically significant. The enhanced healing potential in the non‐reattachment group was explained by the increase in intrinsic angiogenesis/osteogenesis. In the subacute phase, the ACL‐derived cells with the non‐reattached morphologic pattern showed greater and earlier tendon bone healing compared with the cells obtained from the reattached morphologic pattern.

  Wiley, Jun. 2022, Journal of Orthopaedic Research, 41(3) (3), 500 - 510

  Scientific journal


• Robotic arm-assisted posterior-stabilised total knee arthroplasty reduces the amount of tibial bone resection thickness without increasing the rate of postoperative flexion contracture in varus knees in the short term: Comparison with image-free navigated total knee arthroplasty.

  Kazunari Ishida, Nao Shibanuma, Shinya Hayashi, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: This study aimed to compare the bone resection thickness, rate of minimal thickness insert usage, and postoperative range of motion (ROM) between robotic and navigated total knee arthroplasty (TKA). METHODS: Fifty consecutive posterior-stabilised (PS) robotic TKA and 50 case-controlled PS navigated TKA were enroled. Bone resection thickness, rate of minimal thickness insert usage, and postoperative flexion contracture over 5° were statistically compared. RESULTS: The tibial bone resection thickness was significantly thinner in robotic TKA. The insert thickness was significantly lower, and the rate of minimal thickness insert usage was significantly higher in robotic TKA. The ROM at 3 months postoperatively and the rate of postoperative flexion contracture were comparable between the two groups. CONCLUSION: Robotic TKA can reduce the tibial bone resection thickness and increase the rate of minimal thickness insert usage without increasing postoperative flexion contracture as compared with navigated TKA.

  Jun. 2022, The international journal of medical robotics + computer assisted surgery : MRCAS, 18(3) (3), e2370, English, International magazine

  Scientific journal


• Successful Conservative Treatment of an Acute Arterial Occlusion After Total Knee Arthroplasty: Report of 2 Cases and Review of the Literature.

  Kemmei Ikuta, Tomoyuki Matsumoto, Koji Takayama, Naoki Nakano, Yoshinori Takashima, Hiroki Ohnishi, Shinya Hayashi, Yuichi Kuroda, Ryosuke Kuroda

  BACKGROUND Acute arterial occlusion after total knee arthroplasty (TKA) is a rare but occasionally limb-threatening complication. Successful outcomes of surgical treatment for acute arterial occlusion after TKA have been frequently reported in the literature; however, few reports have described conservative treatment. This case report describes the successful conservative treatment of popliteal artery occlusion after TKA. CASE REPORT We report 2 cases of popliteal artery occlusion after TKA that were managed with conservative treatment. In Case 1, a 68-year-old woman presented with a weak dorsalis pedis pulse in the foot and weakness to dorsiflexion of the toe on the operative side immediately after TKA. The operative lower extremity arterial ultrasonography and computed tomography angiography demonstrated the popliteal artery occlusion. In Case 2, a 79-year-old woman presented a cold right foot and lack of popliteal and dorsalis pedis pulse in the operated extremity immediately after TKA, and Doppler ultrasound did not reveal a flow for the dorsalis pedis artery. In both patients, urgent angiographies showed popliteal artery occlusion, and blood flow was observable in the anterior tibial, peroneal, and foot arteries collateral perfusion. Thus, conservative treatments were chosen, and anticoagulant and vasodilator therapies were undergone in both patients. At 6 months after surgery, they were able to walk without intermittent claudication. CONCLUSIONS Conservative treatment can be a good option for popliteal artery occlusion after TKA in cases of rich collateral circulation.

  Apr. 2022, The American journal of case reports, 23, e936295, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 脂肪組織由来間質血管細胞群の軟骨細胞への作用機序の検討

  藤田 雅広, 松本 知之, 林 申也, 傍島 聰, 平中 崇文, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2022, 中部日本整形外科災害外科学会雑誌, 65(春季学会) (春季学会), 143 - 143, Japanese


• 大腿骨近位髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について 多施設共同前向き観察研究

  大江 啓介, 新倉 隆宏, 福井 友章, 林 申也, 黒田 良祐, 酒井 良忠

  (一社)中部日本整形外科災害外科学会, Apr. 2022, 中部日本整形外科災害外科学会雑誌, 65(春季学会) (春季学会), 158 - 158, Japanese


• Peri-prosthetic bone remodeling of hydroxyapatite-coated compaction short stem was not affected by stem alignment.

  Shinya Hayashi, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Toshihisa Maeda, Takahiro Niikura, Ryosuke Kuroda

  BACKGROUND: To improve implant survival through accelerated early bone remodeling during total hip arthroplasty (THA), hydroxyapatite (HA) is widely used as a bioactive coating, which is believed to enhance initial fixation by osseointegration. We aimed to investigate the relationship between stem insertion alignment and postoperative bone mineral density (BMD) changes in patients with full hydroxyapatite-coated (HA) compaction short stem and short tapered-wedge stem. METHODS: This retrospective cohort study enrolled 115 consecutive patients (115 joints) undergoing THA using the full HA compaction short (n = 59) and short tapered-wedge (n = 56) stems. Stem alignment, including anteversion, valgus, and anterior tilt were measured by a three-dimensional template using computed tomography data. Post-operative peri-prosthetic BMD was measured by dual-energy X-ray absorptiometry. The relationship between stem alignment and BMD changes in the stems was analyzed. RESULTS: Patterns of peri-prosthetic BMD changes were similar in both groups. Stem insertion alignments of anteversion, valgus, and anterior tilt were different between the two stem types. Stem alignment of valgus and anterior tilt did not affect peri-prosthetic BMD in either of the stem type. An absolute anteversion difference between stem anteversion and original canal anteversion caused significant peri-prosthetic BMD loss in Gruen zones one and seven in the tapered-wedge stem. However, stem alignment of absolute anteversion difference did not affect BMD changes in the HA compaction stem. CONCLUSIONS: Peri-prosthetic bone remodeling remained unaffected by stem alignment after THA with the new short full HA compaction stem.

  Mar. 2022, Journal of orthopaedic surgery and research, 17(1) (1), 131 - 131, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 高齢大腿骨頸部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について 多施設共同前向き観察研究

  大江 啓介, 新倉 隆宏, 福井 友章, 林 申也, 酒井 良忠, 高原 俊介, 岩倉 崇, 角田 雅也, 柴原 克紀, 正田 悦朗, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S699 - S699, Japanese


• リウマチ性疾患のヒト免疫研究 N-アセチルガラクトサミン転移酵素12(GalNAc-T12)の軟骨細胞への影響の検討

  積山 賢, 橋本 麿和, 舟橋 恵子, 菊池 健一, 藤田 雅広, 高島 良典, 前田 俊恒, 福田 康治, 林 申也, 塩沢 俊一, 松原 司

  (一社)日本リウマチ学会, Mar. 2022, 日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 341 - 341, Japanese


• Rectangular taper shortステムとtaper wedge shortステムのTHA術後ステム周囲骨密度変化とステム前捻による影響の比較検討

  安喰 健祐, 林 申也, 藤代 高明, 黒田 雄一, 亀長 智幸, 高島 良典, 中野 直樹, 前田 俊恒, 松本 知之, 平中 崇文, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S233 - S233, Japanese


• リウマチ性疾患のヒト免疫研究 N-アセチルガラクトサミン転移酵素12(GalNAc-T12)の軟骨細胞への影響の検討

  積山 賢, 橋本 麿和, 舟橋 恵子, 菊池 健一, 藤田 雅広, 高島 良典, 前田 俊恒, 福田 康治, 林 申也, 塩沢 俊一, 松原 司

  (一社)日本リウマチ学会, Mar. 2022, 日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 341 - 341, Japanese


• 関節リウマチ患者における痛み受容チャネルTRPA1ミスセンス変異と疾患活動性との関連

  橋本 麿和, 舟橋 恵子, 積山 賢, 菊池 健一, 藤田 雅広, 高島 良典, 前田 俊恒, 福田 康治, 林 申也, 松原 司

  (一社)日本リウマチ学会, Mar. 2022, 日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 568 - 568, Japanese


• 多剤耐性因子MDR1発現がJAK阻害薬治療効果に与える影響の検討

  菊池 健一, 前田 俊恒, 林 申也, 安喰 健祐, 生田 健明, 藤田 雅広, 高島 良典, 橋本 麿和, 積山 賢, 舟橋 恵子, 福田 康治, 黒田 良祐, 松原 司

  (一社)日本リウマチ学会, Mar. 2022, 日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 570 - 570, Japanese


• IL-6阻害薬は骨びらんによる関節破壊の進行を優位に抑制する

  林 申也, 松原 司, 前田 俊恒, 福田 康治, 舟橋 恵子, 橋本 麿和, 積山 賢, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2022, 日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 588 - 588, Japanese


• RA患者由来滑膜線維芽細胞へのIL-6刺激に対するJAK阻害剤の効果の比較検討

  生田 健明, 林 申也, 前田 俊恒, 高島 良典, 菊池 健一, 藤田 雅広, 安喰 健祐, 福田 康治, 積山 賢, 橋本 麿和, 舟橋 恵子, 黒田 良祐, 松原 司

  (一社)日本リウマチ学会, Mar. 2022, 日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 615 - 615, Japanese


• 高齢大腿骨頸部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について 多施設共同前向き観察研究

  大江 啓介, 新倉 隆宏, 福井 友章, 林 申也, 酒井 良忠, 高原 俊介, 岩倉 崇, 角田 雅也, 柴原 克紀, 正田 悦朗, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S699 - S699, Japanese


• Patients' Characteristics Can Predict Clinical Outcomes Following Hip Arthroscopy by Reflecting the Patterns of Labral Tears: A Retrospective Observational Study.

  Nobuaki Chinzei, Shingo Hashimoto, Shinya Hayashi, Naoki Nakano, Masahiko Haneda, Yuichi Kuroda, Tomoyuki Matsumoto, Ryosuke Kuroda

  PURPOSE: To evaluate the relationship between morphological differences in labral tears and clinical features of the hip joint in patients who underwent hip arthroscopy. MATERIALS AND METHODS: We retrospectively analyzed data from patients who underwent arthroscopic surgery for the treatment of labral tears. Hip labral tears were morphologically classified as longitudinal peripheral tears (group L), radial fibrillated tears (group FI), radial flaps (group FL), and an unstable labrum (group U). Radiographically, the center-edge angle, acetabular roof obliquity, vertical-center-anterior angle, alpha angle, femoral head-neck offset ratio, and crossover sign were evaluated and compared among the groups. The relationship between labral morphology and these radiographic findings, as well as clinical findings, such as age, gender, preoperative range of hip motion, and the clinical outcomes using modified Harris Hip Score (mHHS) were also examined. RESULTS: This study included fifty patients. Groups L and FI were often observed in late middle-aged patients with relatively shallow acetabular coverage. Group FL tears were frequently observed in young males with radiographic features, such as femoroacetabular impingement (FAI), compared to the other groups. Group U comprised mostly young females with relatively shallow acetabular coverage compared to the other groups. For the postoperative mHHS, group FL showed the best score among all groups, with a significant difference between groups FL and FI (p = 0.034). CONCLUSIONS: Our study revealed that morphologically, different labral tears were associated with different clinical features and radiological findings. Especially, our study can provide predictive findings for hip arthroscopists that younger males with FAI show better clinical outcomes when compared to middle-aged females with shallow acetabulum, which is indicative of degenerative hip labral tears. LEVEL OF EVIDENCE: IV case series.

  Feb. 2022, Indian journal of orthopaedics, 56(2) (2), 295 - 302, English, International magazine

  Scientific journal


• Endochondral Bone Tissue Engineering Using Human Induced Pluripotent Stem Cells.

  Michio Arakura, Sang Yang Lee, Tomoaki Fukui, Keisuke Oe, Shunsuke Takahara, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  The use of induced pluripotent stem cells (iPSCs) shows potential in bone regenerative strategies. In this study, we investigated whether implantation of chondrogenically differentiated iPSC-derived mesenchymal stem cells (iMSCs) can lead to successful bone regeneration in nude mice with bone defects. Two human iPSC clones (201B7 and 454E2) were used. After generating iMSCs, chondrogenic differentiation was achieved by three-dimensional pellet culture. Thereafter, a 2-mm defect was created in the radius of nude mice, and chondrogenically differentiated iMSC pellets were transplanted in the defect. Microcomputed tomography imaging was performed 8 weeks posttransplantation to assess bone regeneration. All (100%) radii in the 201B7 cell-derived pellet transplantation group and 7 of 10 (70%) radii in the 454E2 cell-derived pellet transplantation group showed bone union. In contrast, 2 of 11 radii (18%) in the control group showed bone union. Thus, the experimental groups showed significantly higher bone union rates than the control group (p < 0.05). Histological analysis 2 weeks postimplantation in the experimental groups revealed hypertrophic chondrocytes within grafted iMSC pellets and the formation of woven bone around them. This hypertrophic chondrocyte transitioning to newly formed bone suggests that the cartilaginous template can trigger endochondral bone ossification (ECO). Four weeks postimplantation, the cartilage template was reduced in size; newly formed woven bone was predominant in the defect site. New vessels were surrounded by a matrix of woven bone, and hypertrophic chondrocytes transitioning to newly formed bone indicated the progression of ECO. Eight weeks postimplantation, the pellets were completely resorbed and replaced by bone; complete bone union was observed. Dense mature bone developed with evidence of lamellar-like bone formation. Collectively, our results suggest that using iMSC-based cartilage grafts recapitulating the morphogenetic process of ECO in the context of embryonic skeletogenesis is a promising strategy for repairing large bone defects. Impact statement We investigated whether implantation of chondrogenically differentiated iPSC-derived mesenchymal stem cells (iMSCs) could lead to the successful regeneration of bone defects in vivo. We implanted two different clones of human induced pluripotent stem cells into a radial bone defect model. Eleven of 11 (100%) and 7 of 10 (70%) radii in the 201B7 and 454E2 cell-derived pellet transplantation groups, respectively, showed bone union, which were significantly higher than those in the control group [only 2 of 11 radii (18%)]. Overall, our results support the use of iMSC-based cartilage grafts recapitulating the morphogenetic process of endochondral bone ossification for repairing large bone defects.

  Feb. 2022, Tissue engineering. Part A, 28(3-4) (3-4), 184 - 195, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Combination of Anterior Acetabular Coverage and Femoral Head Shape Predicts Femoroacetabular Impingement After Periacetabular Osteotomy.

  Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Ryosuke Kuroda

  BACKGROUND: Femoroacetabular impingement (FAI) after periacetabular osteotomy (PAO) may be affected by both anterior acetabular coverage and femoral head shape. This study aimed to radiographically evaluate the relationship of the combination of acetabular coverage and femoral head shape with the occurrence of FAI after curved PAO. METHODS: In this study, 76 hip joints from patients with symptomatic developmental dysplasia of the hip underwent curved PAO. The relationship between the combined postoperative anterior center-edge and alpha angles (ie, the combination angle) and the occurrence of postoperative FAI was evaluated. Clinical factors and the preoperative and postoperative 3-dimensional center-edge angles, acetabular versions, femoral versions, radiographic alpha angles of the femoral head, and the combination angle were measured and compared to clinical outcomes. RESULTS: The modified Harris Hip Scores, University of California, Los Angeles activity scores, and acetabular coverage angles were significantly improved following curved PAO. Receiver operator characteristic curve analysis demonstrated that the combination angle over 108° may be a predictive factor for the occurrence of FAI after curved PAO. Multivariate analysis demonstrated that an age <40 years (odds ratio 6.6, 95% confidence interval 1.2-36.4, P = .037) and a combination angle <108° (odds ratio 9.2, 95% confidence interval 1.7-50.0, P = .010) were significantly associated with modified Harris Hip Scores ≧90 points. CONCLUSION: A combination angle >108° may be a predictive factor for the occurrence of FAI after curved PAO and impaired clinical outcomes. To avoid postoperative FAI, we propose that osteochondroplasty of the femoral head should be performed for patients with preoperative combination angles >90°.

  Feb. 2022, The Journal of arthroplasty, 37(2) (2), 219 - 225, English, International magazine

  Scientific journal


• Low-Intensity Pulsed Ultrasound Promotes Osteogenic Differentiation of Reamer-Irrigator-Aspirator Graft-Derived Cells in Vitro.

  Kenichi Sawauchi, Tomoaki Fukui, Keisuke Oe, Yohei Kumabe, Takahiro Oda, Ryo Yoshikawa, Kyohei Takase, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  Recently, reamer-irrigator-aspirator (RIA) systems have been increasingly used to harvest autologous bone grafts. RIA graft materials contain bone marrow, which provides a viable source to derive large numbers of mesenchymal stem cells. Low-intensity pulsed ultrasound (LIPUS) significantly accelerates the differentiation of stem cells derived from bone marrow. This in vitro study investigated the effect of LIPUS on the osteogenic activity and differentiation of RIA graft-derived cells. A small amount of RIA graft was obtained from seven patients. After the cells derived from RIA grafts were cultured, they were divided into two groups: the LIPUS and control groups. LIPUS was applied once daily for 20 min (1.5 MHz, pulse duration: 200 µs, pulse repetition rate: 1 kHz, spatial average-temporal average intensity: 30 mW/cm2). Alkaline phosphatase activity (113.4% and 130.1% on days 7 and 14), expression of osteoblast-related genes (ALP, Runx2) and mineralization (135.2% on day 21) of the RIA graft-derived cells were significantly higher in the LIPUS group than in the control group. However, LIPUS did not affect the cell proliferation of RIA graft-derived cells. This study indicates that LIPUS may enhance the healing of non-union and critical bone defects treated by autologous bone grafting using the RIA system.

  Feb. 2022, Ultrasound in medicine & biology, 48(2) (2), 313 - 322, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Histopathological changes of synovial tissue in rheumatoid arthritis patients treated with TNF-α inhibitors or IL-6 inhibitors.

  Yoshinori Takashima, Shinya Hayashi, Toshihisa Maeda, Koji Fukuda, Yuma Onoi, Syotaro Tachibana, Kemmei Ikuta, Kensuke Anjiki, Masahiro Fujita, Kenichi Kikuchi, Tomoyuki Kamenaga, Ryosuke Kuroda, Tsukasa Matsubara

  OBJECTIVES: To investigate the cell types that undergo apoptosis in TNF-α inhibitor (TNFI)- and IL-6 inhibitor (IL-6I)-treated synovia of RA patients, and to observe and compare histological changes in them. METHODS: Synovial tissue was collected during total knee arthroplasty from 20 RA patients who were divided into three groups based on RA treatment received: conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs, control group), TNFI, or IL-6I. Tissue samples were subjected to haematoxylin and eosin staining, terminal deoxynucleotidyl transferase fluorescein-deoxyuridine triphosphate nick end labelling (TUNEL), immuno-histochemistry (IHC) and immunofluorescence staining for, respectively, histopathological assessment, apoptosis detection and IHC evaluation and scoring. RESULTS: TUNEL-positive cells were detected surrounding the discoid fibrosis unique to the TNFI group, while those in the IL-6I group were distributed widely, especially surrounding the blood vessels. IHC revealed that in TNFI-treated tissue, CD86- and CD80-positive cells were detected only in the lining and sublining layer, while CD163- and CD206-positive cells were detected more broadly; in the IL-6I-treated tissue, all four were detected widely but their levels were lower than in the control group. Immunofluorescence also revealed macrophages mainly were the apoptotic cells in the lining and sublining layers of TNFI group. TUNEL Expression levels of CD20- and CD3-positive cells were remarkably lower in the IL-6I group, compared with the control and TNFI groups. CONCLUSIONS: TNFIs and IL-6Is target different action sites and synovial cell types, resulting in histopathological features of synovium distinct from one another.

  Jan. 2022, Clinical and experimental rheumatology, English, International magazine

  Scientific journal


• Fully hydroxyapatite-coated compaction broached and triple-tapered stem may reduce the risk of stress shielding after primary total hip arthroplasty.

  Yuichi Kuroda, Shingo Hashimoto, Shinya Hayashi, Naoki Nakano, Takaaki Fujishiro, Takafumi Hiranaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: Changes in bone mineral density (BMD) around the fully hydroxyapatite (HA)-coated compaction broached and triple-tapered stem, namely, Polarstem, after total hip arthroplasty (THA) are currently unknown. Therefore, the aims of this study were to investigate clinical outcomes of Polarstem, mainly postoperative temporal changes in BMD around the stem for 2 years, and to compare them with those of HA-coated and non-HA-coated tapered-wedge stems. METHODS: This retrospective cohort study enrolled 100 consecutive patients who underwent THA using Polarstem (n = 38), HA-coated Anthology (n = 31), and non-HA-coated Anthology (n = 31). BMD was evaluated using dual-energy X-ray absorptiometry in seven regions according to the Gruen zones. Postoperatively, BMD around the stem was assessed within 2 months (baseline BMD) and at 6, 12, and 24 months. A change in BMD was defined as the value calculated by dividing each postoperative BMD value at 6, 12, and 24 months by the baseline BMD value. Changes in BMD and radiographic parameters such as stress shielding and spot welds were compared among the three stems. RESULTS: The incidence rate of stress shielding in the Polarstem group was significantly lower than those in the other two groups (p = 0.007). The change in BMD in Zone 7 of Polarstem was significantly more than that of the other two groups at 12 and 24 months postoperatively (p = 0.030 and p = 0.009, respectively). CONCLUSION: Polarstem, a fully HA-coated compaction broached and triple-tapered stem, maintained BMD around the femoral calcar until 2 years postoperatively and could reduce the risk of stress shielding compared with tapered-wedge stems.

  Jan. 2022, Archives of orthopaedic and trauma surgery, 142(12) (12), 4087 - 4093, English, International magazine

  Scientific journal


• Anterior acetabular coverage and femoral head-neck measurements predict postoperative anterior impingement: A simulation study.

  Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Ryosuke Kuroda

  The aim of this simulation study was to evaluate the relationship of elements of anterior acetabular coverage and femoral head-neck shape with the occurrence of postoperative anterior impingement after curved periacetabular osteotomy (PAO). Sixty-two patients with symptomatic developmental dysplasia of the hip who had undergone curved PAO were selected. The likelihood of developing postoperative anterior impingement was explored through simulations of the range of motion by collision detection of the pelvis and femur. Postoperative anterior impingement was defined as impingement that occurred during postoperative bone flexion <105° or postoperative internal rotation <20° at 90° flexion. The three-dimensional center-edge (CE) angles, acetabular and femoral versions, radiographic alpha angles of the femoral head, combination angles of anterior CE and alpha angles, and combined anteversions of acetabular and femoral versions were compared between patients with postoperative anterior impingement and nonimpingement. A receiver operator characteristic (ROC) analysis was conducted to determine thresholds of the examined radiographic parameters and calculate their accuracy for predicting postoperative anterior impingement. A multivariate analysis was performed to test whether combined anteversion, anterior CE angle, and combination angle are associated with excellent modified Harris Hip Scores (mHHSs). ROC analysis demonstrated a combination angle ≥108° was predictive of the occurrence of postoperative anterior impingement after curved PAO, which can lead to impaired clinical outcomes. Conversely, a combination angle <108° was significantly associated with mHHS ≥ 90 points. To avoid postoperative anterior impingement, osteochondroplasty of the femoral head or anterior CE angle control should be performed for patients with preoperative combination angles ≥90°.

  Jan. 2022, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, English, International magazine

  Scientific journal


• Immunohistochemical analysis revealed the expression of bone morphogenetic proteins-4, 6, 7, and 9 in human induced membrane samples treated with the Masquelet technique.

  Takahiro Niikura, Takahiro Oda, Naoe Jimbo, Masato Komatsu, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Tomoo Itoh, Ryosuke Kuroda

  BACKGROUND: Induced membrane (IM) is the key component of Masquelet reconstruction surgery for the treatment of bone defects. IM is formed around the cement spacer and is known to secrete growth factors and osteoinductive factors. However, there is limited evidence available concerning the presence of osteoinductive factors in IM. This study aimed to investigate the existence of bone morphogenetic proteins (BMPs) in IM harvested from patients during the treatment of bone defects using the Masquelet technique. METHODS: This study involved six patients whose bone defects had been treated using the Masquelet technique. The affected sites were the femur (n = 3) and the tibia (n = 3). During the second-stage surgery, 1 cm2 pieces of IM were harvested. Histological sections of IM were immunostained with anti-BMP-4, 6, 7, and 9 antibodies. Human bone tissue served as the positive control. RESULTS: The presence of BMP-4, 6, 7, and 9 was observed in all IM samples. Further, immunolocalization of BMP-4, 6, 7, and 9 was observed in blood vessels and fibroblasts in all IM samples. Immunolocalization of BMP-4, 6, 7, and 9 was also observed in bone tissue within the IM in one sample, in which osteogenesis inside the IM was observed. CONCLUSIONS: This study showed that osteoinductive factors BMP-4, 6, 7, and 9 were present in the IM harvested from patients, providing evidence indicating that the Masquelet technique effectively contributes to healing large bone defects. Therefore, it may be possible for surgeons to omit the addition of BMPs to bone grafts, given the endogenous secretion of BMPs from the IM.

  Jan. 2022, Journal of orthopaedic surgery and research, 17(1) (1), 29 - 29, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Preoperative varus deformity of the knee affects the intraoperative joint gap in unicompartmental knee arthroplasty.

  Naoki Nakano, Koji Takayama, Yuichi Kuroda, Toshihisa Maeda, Shingo Hashimoto, Kazunari Ishida, Shinya Hayashi, Yuichi Hoshino, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: It is generally believed that contraction of the soft tissue structures on the medial side may occur in the knee with severe varus deformity. However, the relationship between the severity of varus deformity of the knee and the intraoperative soft tissue balance in unicompartmental knee arthroplasty (UKA) has not been well reported thus far. METHODS: One hundred and three consecutive medial UKAs were enrolled. After the femoral trial prosthesis was placed, the component gap was measured at 10° (extension) and 120° (flexion) of flexion using a UKA tensor. The pre-osteotomy gap was then calculated from the thickness of the bone cut. Paired Student's t-test was used to compare the component gap, as well as the pre-osteotomy gap, in extension and those in flexion. The relationship between the preoperative Hip-Knee-Ankle (HKA) angle and the pre-osteotomy gap was analysed using Pearson's correlation coefficient and simple linear regression analysis. RESULTS: The component gap in extension was significantly smaller than that in flexion while the pre-osteotomy gap in extension was significantly wider than that in flexion. There was a positive correlation between the severity of varus deformation in preoperative knee and the pre-osteotomy gap in extension, while there was no correlation between the preoperative HKA angle and the pre-osteotomy gap in flexion. CONCLUSIONS: The tension of the medial tightness does not correlate with the degree of preoperative varus deformity in UKA.

  Oct. 2021, The Knee, 32, 90 - 96, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Robotic-arm assisted THA can achieve precise cup positioning in developmental dysplasia of the hip : a case control study.

  Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Kazunari Ishida, Nao Shibanuma, Ryosuke Kuroda

  AIMS: This study aimed to evaluate the accuracy of implant placement with robotic-arm assisted total hip arthroplasty (THA) in patients with developmental dysplasia of the hip (DDH). METHODS: The study analyzed a consecutive series of 69 patients who underwent robotic-arm assisted THA between September 2018 and December 2019. Of these, 30 patients had DDH and were classified according to the Crowe type. Acetabular component alignment and 3D positions were measured using pre- and postoperative CT data. The absolute differences of cup alignment and 3D position were compared between DDH and non-DDH patients. Moreover, these differences were analyzed in relation to the severity of DDH. The discrepancy of leg length and combined offset compared with contralateral hip were measured. RESULTS: The mean values of absolute differences (postoperative CT-preoperative plan) were 1.7° (standard deviation (SD) 2.0) (inclination) and 2.5° (SD 2.1°) (anteversion) in DDH patients, and no significant differences were found between non-DDH and DDH patients. The mean absolute differences for 3D cup position were 1.1 mm (SD 1.0) (coronal plane) and 1.2 mm (SD 2.1) (axial plane) in DDH patients, and no significant differences were found between two groups. No significant difference was found either in cup alignment between postoperative CT and navigation record after cup screws or in the severity of DDH. Excellent restoration of leg length and combined offset were achieved in both groups. CONCLUSION: We demonstrated that robotic-assisted THA may achieve precise cup positioning in DDH patients, and may be useful in those with severe DDH. Cite this article: Bone Joint Res 2021;10(10):629-638.

  Oct. 2021, Bone & joint research, 10(10) (10), 629 - 638, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Lateral osteoarthritis progression is associated with a postoperative residual tibiofemoral subluxation in Oxford UKA.

  Tomoyuki Kamenaga, Takafumi Hiranaka, Yuichi Hida, Naoki Nakano, Yuichi Kuroda, Masanori Tsubosaka, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: Lateral compartment osteoarthritis progression (LOP) is a major complication after Oxford mobile-bearing unicompartmental knee arthroplasty (OUKA). This study aimed to identify the association between tibiofemoral subluxation (TFS) and LOP after OUKA. Patients whose TFS was uncorrectable according to preoperative stress radiographs were hypothesised to develop residual TFS even after surgery, and thought to be more likely to develop LOP. METHODS: The study included 201 patients who underwent medial OUKA. Fifteen patients showed increases in LOP of at least two Kellgren-Lawrence grades after surgery [progression (P) group], while the others had no progression (N group, n = 186). TFS was measured on preoperative full leg weight-bearing radiographs, valgus stress radiographs and postoperative plain radiographs. Valgus stress radiographs were obtained using a firm manual valgus force with the knee flexed at 20°. Leg alignment, Oxford knee score (OKS), and revision rates were assessed. RESULTS: The P group had significantly higher TFS values on preoperative valgus stress (6.8° ± 2.2° vs. 4.5° ± 2.0°; P < 0.001) and postoperative radiographs (6.6° ± 2.3° vs. 4.6° ± 2.9°; P < 0.001) than the N group. Patients with postoperative residual TFS and postoperative valgus alignment were more likely to have LOP, but 9 of the 15 LOP patients did not show postoperative valgus alignment. The P group had significantly poorer postoperative OKS (33.0 ± 10.2 vs. 37.4 ± 6.5, P = 0.017) and a higher rate of revision (6/15 vs 6/186; odds ratio = 19.16; 95% CI = 4.98-76.05, P < 0.001). CONCLUSION: OA progression in the lateral compartment after medial OUKA might be associated with postoperative residual TFS, but does not always coexist with postoperative valgus alignment. Preoperative assessment of TFS with valgus stress could be a potential predictor of postoperative residual TFS and LOP. LEVEL OF EVIDENCE: Level III.

  Sep. 2021, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 30(9) (9), 3236 - 3243, English, International magazine

  Scientific journal


• Preoperative uncorrectable tibiofemoral subluxation can worsen clinical outcomes after fixed-bearing unicompartmental knee arthroplasty: a retrospective analysis.

  Tomoyuki Kamenaga, Naoki Nakano, Kazunari Ishida, Masanori Tsubosaka, Yuichi Kuroda, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  INTRODUCTION: The presence of tibiofemoral subluxation (TFS) in patients with unicompartmental arthritis, a potential contraindication to unicompartmental knee arthroplasty (UKA), remains controversial and is not commonly discussed. This study aimed to determine the predictability of postoperative TFS before surgery and the effect of TFS on clinical outcomes after fixed-bearing UKA. MATERIALS AND METHODS: In total, 70 patients with anteromedial osteoarthritis and osteonecrosis of the knee who underwent fixed-bearing UKA from January 2015 to January 2017 were included. The preoperative TFS was assessed using plain anteroposterior and valgus stress radiographs. The patients were classified into three groups as follows: group A (acceptable TFS, n = 36) comprising patients with preoperative TFS less than 5.0 mm; group C (correctable TFS, n = 17) comprising patients with preoperative TFS of more than 5.0 mm but corrected to less than 5.0 mm under valgus stress; and group U (uncorrectable TFS, n = 17) comprising patients with preoperative TFS of more than 5.0 mm under valgus stress. Patient-derived clinical scores were assessed with the 2011 Knee Society Score preoperatively and 2 years postoperatively. The results were compared among the three groups using analysis of variance. RESULTS: Group U showed significantly higher postoperative TFS than groups A and C. Improvements in "symptoms" and "patient satisfaction" scores 2 years after surgery were significantly higher in groups A and C than in group U. CONCLUSION: Preoperative assessment of TFS under valgus stress could be a predictor of postoperative TFS. Furthermore, preoperative uncorrectable TFS could increase pain and decrease patient satisfaction 2 years after undergoing fixed-bearing UKA.

  Sep. 2021, Archives of orthopaedic and trauma surgery, English, International magazine

  Scientific journal


• Expression profiling of genes in rheumatoid fibroblast-like synoviocytes regulated by Fas ligand via cDNA microarray analysis.

  Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Tomoyuki Matsumoto, Ryosuke Kuroda

  Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation in synovial tissues. Hyperplasia of synovial tissues leads to the formation of pannus that invades the joint cartilage and bone, resulting in joint destruction. Fas ligand (FasL), which is a member of the tumor necrosis factor superfamily, contributes to the pathogenesis of autoimmune diseases, including RA. The current study attempted to identify genes whose expressions in rheumatoid fibroblast-like synoviocytes (RA-FLS) were regulated by FasL, using cDNA microarray. A total of four individual lines of primary cultured RA-FLS were incubated either with recombinant human FasL protein or PBS as an unstimulated control for 12 h. Gene expression was detected using a microarray assay. The results revealed the expression profiles of genes in RA-FLS regulated by Fas and investigated the functions of the genes that were regulated. Among the genes in this profile, the mRNA expression changes of the following genes were indicated to be of note using RT-qPCR: Dual specificity phosphatase 6, epiregulin, interleukin 11, angiopoietin-like 7, protein inhibitor of activated STAT 2 and growth differentiation factor 5. These genes may affect the pathogenesis of RA by affecting apoptosis, proliferation, cytokine production, cytokine-induced inflammation, intracellular signaling, angiogenesis, bone destruction and chondrogenesis. To the best of our knowledge, the current study is the first study to reveal the expression profile of genes in RA-FLS regulated by FasL. The data demonstrated that FasL may regulate the expression of a number of key molecules in RA-FLS, thus affecting RA pathogenesis. Further studies of the genes detected may improve the understanding of RA pathogenesis and provide novel treatment targets for RA.

  Sep. 2021, Experimental and therapeutic medicine, 22(3) (3), 1000 - 1000, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Outcomes of total knee replacement with the use of a NexGen MIS Tibial Component (Mini-keel) : a systematic review.

  Naoki Nakano, Kiyonori Mizuno, Koji Takayama, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  NexGen MIS Tibial Component (Mini-keel) is a tibial component specially developed for minimally invasive surgery in total knee replacement (TKR), and the size limitations of its design and the modular system could affect tibial fixation strength, however, this has not been precisely evaluated thus far. This study aimed to systematically review the literature describing the outcome following TKR with the use of a Mini-keel. Electronic searches of databases were undertaken in July 2019 by two experienced orthopaedic surgeons according to the PRISMA guidelines for literature describing the outcomes of TKR with the use of a Mini-keel. Quality of studies was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. The initial search found a total of 623 studies from all the databases. Seven studies met all the inclusion criteria and were eligible for critical appraisal and quality assessment. In total, 2,198 cases were included in the systematic review. Thirty-five revision cases due to aseptic loosening were found from the systematic review. Two studies were negative about using a Mini-keel and three studies were positive about it, while the other two studies did not judge the quality of a Mini-keel. There have been conflicting conclusions among studies for the use of a Mini-keel. There remains a paucity of prospective cohort studies between TKRs with the use of a Mini-keel and those with the use of a conventional implant, which makes it difficult to determine the usefulness and reliability of this implant.

  Sep. 2021, Acta orthopaedica Belgica, 87(3) (3), 469 - 478, English, International magazine

  Scientific journal


• Hydroxyapatite-coated compaction short stem represents a characteristic pattern of peri-prosthetic bone remodelling after total hip arthroplasty.

  Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Takahiro Niikura, Ryosuke Kuroda

  PURPOSE: We aimed to investigate the differences in peri-prosthetic bone remodelling between the full hydroxyapatite (HA)-collared compaction short stem and the short tapered-wedge stem. METHODS: This retrospective cohort study enrolled 159 consecutive patients (159 joints) undergoing total hip arthroplasty (THA) using the full HA compaction short (n = 64) and short tapered-wedge (n = 95) stems. Body mass index (BMI), peri-prosthetic bone mineral density (BMD), and clinical factors, including the Japanese Orthopaedic Association score and the University of California Los Angeles (UCLA) activity score were assessed and compared. RESULTS: Stem related complications were seen in three cases. Both groups showed similar peri-prosthetic BMD changes. Peri-prosthetic BMD was almost maintained in the distal femur and Gruen zone 6 with both type of stems, but significant BMD loss was found in zones 1 and 7 in both groups and in zone 2 of the full HA compaction stem group. No significant correlations were found between the proximal femoral BMD changes and the age, BMI, and UCLA score in both the full HA compaction and tapered-wedge stem groups. Femoral bone shape affected the peri-prosthetic BMD changes in the tapered-wedge stem group but not in the full HA compaction group. The stem collar of the full HA compaction stem did not affect peri-prosthetic BMD, but unique bone remodelling in the calcar region was observed in 27.6% cases. A significant difference in the peri-prosthetic BMD changes at Gruen zone 2 was found in patients with or without thigh pain. CONCLUSION: Peri-prosthetic bone remodelling remained unaffected by clinical and radiographic factors after THA with the new short full HA compaction stem. Therefore, this new stem may be useful in a variety of cases.

  Aug. 2021, Archives of orthopaedic and trauma surgery, English, International magazine

  Scientific journal


• 人工知能モデルによる関節リウマチへの生物学的製剤治療効果の予測

  前田 俊恒, 林 申也, 乾 淳幸, 黒田 雄一, 中野 直樹, 西本 華子, 橋本 慎吾, 美舩 泰, 松本 知之, 松原 司, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1732 - S1732, Japanese


• Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1β-induced inflammation.

  Yoshinori Takashima, Shinya Hayashi, Koji Fukuda, Toshihisa Maeda, Masanori Tsubosaka, Tomoyuki Kamenaga, Kenichi Kikuchi, Masahiro Fujita, Yuichi Kuroda, Shingo Hashimoto, Naoki Nakano, Tomoyuki Matsumoto, Ryosuke Kuroda

  We recently reported that cyclin-dependent kinase inhibitor 1 (p21) deficiency induces osteoarthritis susceptibility. Here, we determined the mechanism underlying the effect of p21 in synovial and cartilage tissues in RA. The knee joints of p21-knockout (p21-/-) (n = 16) and wild type C57BL/6 (p21+/+) mice (n = 16) served as in vivo models of collagen antibody-induced arthritis (CAIA). Arthritis severity was evaluated by immunological and histological analyses. The response of p21 small-interfering RNA (siRNA)-treated human RA FLSs (n = 5 per group) to interleukin (IL)-1β stimulation was determined in vitro. Arthritis scores were higher in p21-/- mice than in p21+/+ mice. More severe synovitis, earlier loss of Safranin-O staining, and cartilage destruction were observed in p21-/- mice compared to p21+/+ mice. p21-/- mice expressed higher levels of IL-1β, TNF-α, F4/80, CD86, p-IKKα/β, and matrix metalloproteinases (MMPs) in cartilage and synovial tissues via IL-1β-induced NF-kB signaling. IL-1β stimulation significantly increased IL-6, IL-8, and MMP expression, and enhanced IKKα/β and IκBα phosphorylation in human FLSs. p21-deficient CAIA mice are susceptible to RA phenotype alterations, including joint cartilage destruction and severe synovitis. Therefore, p21 may have a regulatory role in inflammatory cytokine production including IL-1β, IL-6, and TNF-α.

  Jun. 2021, Scientific reports, 11(1) (1), 12516 - 12516, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Modern femoral component design in total knee arthroplasty shows a lower patellar contact force during knee flexion compared with its predecessor.

  Naoki Nakano, Yuichi Kuroda, Toshihisa Maeda, Koji Takayama, Shingo Hashimoto, Kazunari Ishida, Shinya Hayashi, Yuichi Hoshino, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: The relationship between the femoral component design in total knee arthroplasty (TKA) and the patellofemoral contact force, as well as the soft tissue balance, has not been well reported thus far. METHODS: Twenty-eight mobile-bearing posterior-stabilized (PS) TKAs using the traditional model (PFC Sigma) and 27 mobile-bearing PS TKAs using the latest model (Attune) were included. Surgeries were performed using the measured resection technique assisted with the computed tomography (CT)-based free-hand navigation system. After all the trial components were placed, patellar contact forces on the medial and lateral sides were measured using two uniaxial ultrathin force transducers with the knee at 0°, 10°, 30°, 60°, 90°, 120°, and 135° of flexion. The joint component gap and the varus ligament balance of the femorotibial joint were also measured. The non-paired Student's t-test was conducted to compare the values of the two groups. RESULTS: The medial patellar contact force was significantly lower for Attune group than for PFC Sigma group at 120° of knee flexion (P = 0.0058). The lateral patellar contact force was also significantly lower for Attune group than PFC Sigma group at 120° and 135° of knee flexion (P = 0.0068 and P = 0.036). The joint component gap, as well as the varus ligament balance, showed no statistically significant difference between the two groups. CONCLUSIONS: Reduced thickness and width of the anterior flange of the femoral component in the Attune may play a role in low patellar contact force.

  Jun. 2021, The Knee, 30, 1 - 8, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Comparison of clinical and biomechanical outcomes between the kinematic and mechanical alignment methods in total knee arthroplasty: Protocol for a multicenter randomized controlled trial.

  Yoshinori Takashima, Tomoyuki Matsumoto, Koji Takayama, Naoki Nakano, Yuichi Kuroda, Masanori Tsubosaka, Tomoyuki Kamenaga, Kenichi Kikuchi, Masahiro Fujita, Kemmei Ikuta, Kensuke Anjiki, Shinya Hayashi, Shingo Hashimoto, Toshihisa Maeda, Takao Inokuchi, Mitsunori Toda, Takaaki Chin, Ryosuke Kuroda

  Introduction: The concept of anatomic restoration has garnered considerable interest in the form of kinematically aligned total knee arthroplasty (KA-TKA). KA-TKAs have been reported to reproduce natural alignment and kinematics. However, few randomized controlled trials (RCTs) have compared the biomechanical outcomes and the long-term clinical outcomes of KA-TKA with those of mechanically aligned TKA (MA-TKA). We aim to investigate the long-term clinical and biomechanical effects of KA-TKA and to determine whether KA-TKA or MA-TKA is more appropriate for primary TKA. Methods: This trial will compare clinical and biomechanical outcomes of KA-TKA to those of MA-TKA. Two hundred patients will be enrolled in the RCT and randomized into KA-TKA or MA-TKA groups. Both the groups will be evaluated 1 week before the operation, on the day of the operation, 6 months after the operation, and 1, 5, and 10 years after the operation. The primary outcome is the difference between preoperative and 1-year postoperative functional activity scores of the 2011 Knee Society Score (2011 KSS) in both groups as well as the differences between the scores of both groups. The secondary outcomes will include differences in symptom, satisfaction, and expectation scores of the 2011 KSS, intraoperative kinematics evaluation, postoperative clinical outcomes and complications, pre- and postoperative gait analyses and radiograph evaluations between both KA-TKA and MA-TKA.

  Jun. 2021, Contemporary clinical trials communications, 22, 100775 - 100775, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Comparison of plantar pressure distribution during walking and lower limb alignment between modified kinematically and mechanically aligned total knee arthroplasty.

  Tomoyuki Kamenaga, Naoki Nakano, Koji Takayama, Masanori Tsubosaka, Yoshinori Takashima, Kenichi Kikuchi, Masahiro Fujita, Yuichi Kuroda, Shingo Hashimoto, Shinya Hayashi, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Lower extremity alignment is very important after total knee arthroplasty (TKA). This study aimed to compare the plantar pressure distribution while walking and the overall limb alignment, including the hindfoot, between kinematically (KA) and mechanically aligned (MA) TKA. The plantar pressure distribution was investigated using a pressure plate during walking and one-leg standing among four groups: patients one year after KA-TKA (KA group; n = 25), patients one year after MA-TKA (MA group, n = 25), patients with osteoarthritis (OA) undergoing non-surgical care (OA group, n = 25), and healthy controls (Healthy group; n = 25). Conventional and true mechanical axes (the line from the femoral head to the lowest point of the calcaneus) were evaluated on unipedal standing long-leg radiographs in the KA, MA, and OA groups. Results were compared using analysis of variance. The OA group showed a lateral loading pattern in the mid- and rearfoot, while the MA group showed a medial rearfoot loading pattern during walking. On the contrary, the KA and Healthy groups showed an almost equal pressure distribution between the medial and lateral rearfoot. Moreover, although both mechanical axes in the KA group passed through the knee more medially, a more neutral alignment was achieved in the true mechanical axis compared to that in the MA group. KA-TKA results in more neutral weight-bearing through the true mechanical axis and allows patients to walk while maintaining medial and lateral rearfoot pressure more evenly than MA-TKA.

  May 2021, Journal of biomechanics, 120, 110379 - 110379, English, International magazine

  Scientific journal


• Femoro-Epiphyseal Acetabular Roof (FEAR) Index and Anterior Acetabular Coverage Correlate With Labral Length in Developmental Dysplasia of the Hip.

  Yuichi Kuroda, Shingo Hashimoto, Masayoshi Saito, Tomoyuki Matsumoto, Naoki Nakano, Ryosuke Kuroda, Shinya Hayashi

  PURPOSE: The aim of this study was to evaluate the association between labral length and radiographic parameters of lateral and anterior acetabular coverage and the femoro-epiphyseal acetabular roof (FEAR) index in patients with developmental dysplasia of the hip (DDH). METHODS: We retrospectively analyzed data from patients with DDH who visited our hip joint clinic for the first time due to hip symptoms. DDH presence was defined as a lateral center-edge angle (LCEA) of ≤25°. The labral lengths on the anterior and lateral sides were measured on central axial and central coronal slices of T1-weighted magnetic resonance imaging, respectively. The Pearson correlation coefficients (r) and simple linear regression analyses were performed to determine the association of the lateral and anterior labral lengths with the radiographic parameters, including the LCEA, acetabular roof obliquity, FEAR index, anterior wall index, and vertical center anterior angle. RESULTS: This study included 88 patients, with a mean age of 39.6 ± 11.8 years. There were 65 women and 23 men. The lateral and anterior labral lengths correlated with all parameters of dysplasia. Specifically, the lateral labral length had a strong positive correlation with the FEAR index (R = 0.65, P < .001). The anterior labral length had a strong negative correlation with the anterior wall index (R = -0.66, P < .001). CONCLUSIONS: The lateral labral length had a strong positive correlation with the FEAR index. Furthermore, the anterior labral length had a correlation with the anterior dysplasia. LEVEL OF EVIDENCE: Level III, retrospective cross-sectional study.

  May 2021, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, English, International magazine

  Scientific journal


• Clinical experience of the use of reamer irrigator aspirator in Japanese patients: A report of the first 42 cases.

  Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: A reamer irrigator aspirator (RIA) can be used to harvest substantial amounts of autologous bone and debride the intramedullary canal. Clinical experience using reamer irrigator aspirators in Japan is very limited. The applicability of the reamer irrigator aspirator head with a minimum diameter of 12 mm for Japanese people is often questioned as the Japanese are smaller than Americans and Europeans. There are no reports of complications in Japanese patients. This study aimed to retrospectively review clinical cases and describe reamer irrigator aspirator use in Japanese patients. METHODS: All patients for whom a reamer irrigator aspirator was used during surgery at our hospital between January 2014 and September 2018 were included. The patients' clinical and radiographic data were retrospectively reviewed. RESULTS: Data of 40 patients (42 cases) were collected. The reamer irrigator aspirator was used for bone graft harvesting in 32 cases, intramedullary debridement and irrigation in 9 cases, and reaming for exchange nailing in 1 case. The diameter of the reamer irrigator aspirator reamer head was 12 mm in 22 cases (53.7%), 12.5 mm in 4 cases (9.8%), 13 mm in 9 cases (22.0%), 13.5 mm in 1 case (2.4%), 14.0 mm in 1 case (2.4%), 14.5 mm in 1 case (2.4%), and 15 mm in 4 cases (9.8%). Mean intraoperative bleeding volume was 1158.6 mL (range, 100-3800 mL). We experienced no difficulty inserting the reamer irrigator aspirator into the intramedullary canals and no cases of insertion-related intraoperative fracture. Five cortical perforations (11.9%) were observed on postoperative computed tomography scans, although no patient was symptomatic. One case (2.4%) of postoperative femur fracture occurred. CONCLUSIONS: Reamer irrigator aspirators can be used in Japanese patients. Smaller reamer head sizes were mainly used in our experience. We should manage complications as in previous reports from Western countries.

  May 2021, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 26(3) (3), 459 - 465, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Obesity is associated with less favorable outcomes following hip arthroscopic surgery: a systematic review and meta-analysis.

  Yuichi Kuroda, Shingo Hashimoto, Masayoshi Saito, Shinya Hayashi, Naoki Nakano, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: The aim of this study was to systematically review the existing literature comparing the postoperative outcomes after following hip arthroscopy in obese and non-obese patients. METHODS: Studies comparing the outcomes following hip arthroscopy of obese and non-obese patients were systematically identified via a computer-assisted literature search of Pubmed (Medline), EMBASE, and Cochrane Library using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Studies comparing the outcome of hip arthroscopy in different body mass index (BMI) groups were included. Data including patient-reported outcome measures (PROMs), revision arthroscopy rate, conversion rate to total hip arthroplasty (THA), and complications were collected. The methodological index for non-randomized studies (MINORS) and Newcastle-Ottawa Scale (NOS) were used to assess the quality of each study quality. The effect of heterogeneity was quantified by calculating the I2 value. RESULTS: A total of eight studies were finally included in the qualitative analysis, and three studies of high quality involving 373 hips were included in the quantitative assessment. All the studies defined obesity as a BMI of  ≥ 30 kg/m2. The modified Harris Hip Score and the Non-Arthritic Hip Score were 5.1 (95% CI 1.1-9.1) and 9.0 (95% CI 5.0-13.1) points lower, respectively, in the obese group than in the non-obese group. The pooled odds ratios were 1.2 (95% CI 0.5-2.7) for revision arthroscopy, 2.4 (95% CI 1.3-4.6) for conversion to THA, and 3.2 (95% CI 1.2-8.6 for complications in favor of the non-obese group. The heterogeneity was low in all outcome assessments (I2 0-18%). CONCLUSION: Obese patients had significantly lower PROMs than non-obese patients following hip arthroscopic surgery, and the THA conversion and complication rates were 2.4 times and 3.2 times higher, respectively. Understanding the effect of obesity on hip arthroscopy will allow appropriate surgical indications for surgery to be further refined and help obese patients to understand their individual risk profile. LEVEL OF EVIDENCE: Systematic review of Level III-IV studies, Level IV.

  May 2021, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 29(5) (5), 1483 - 1493, English, International magazine

  Scientific journal


• Histological analysis of induced membranes in patients whose bone defects were treated with the Masquelet technique to identify factors affecting the vascularity of induced membranes.

  Takahiro Niikura, Naoe Jimbo, Masato Komatsu, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Yoshitada Sakai, Tomoo Itoh, Ryosuke Kuroda

  BACKGROUND: Rich vascularity of the induced membrane (IM) is important for Masquelet reconstruction surgery. The factors affecting IM vascularity are not completely understood. This study aimed to investigate these factors using histological samples of human IMs. METHODS: We retrospectively evaluated 36 patients whose bone defects were treated using the Masquelet technique. Two clinical pathologists analyzed histological sections of IM pieces (1 cm2). The number of blood vessels per 1 mm2 was counted and compared among men and women, femur or tibia, with and without free flap surgery, antibiotic impregnation to the cement, osteogenesis inside the membrane, smoking, and diabetes mellitus. The number of blood vessels within the same patient was compared among different time points. Correlation analysis was performed among blood vessel numbers and patient age, duration of cement spacer placement, and histological grading scales (inflammation, foreign body reaction, and fibrosis). RESULTS: IM formation with rich vascularity and some inflammation, foreign body reaction, and fibrosis were histologically confirmed in all patients. We found 37.4 ± 19.1 blood vessels per 1 mm2. The number of blood vessels was significantly lower in patients with than in those without free flap surgery; it was higher in patients with osteogenesis inside the IM. No significant correlations were found in any of the analyses. CONCLUSION: Sex, patient age, smoking, diabetes mellitus, femur or tibia, duration of cement spacer placement, and antibiotic impregnation to the cement did not affect IM vascularization. IM vascularization was reduced in patients with than in those without free flap surgery.

  Apr. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 248 - 248, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Short distance from the keel to the posterior tibial cortex is associated with fracture after cementless Oxford UKA in Asian patients.

  Tomoyuki Kamenaga, Takafumi Hiranaka, Naoki Nakano, Shinya Hayashi, Takaaki Fujishiro, Koji Okamoto, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: Tibial plateau fractures are serious complications of Oxford mobile-bearing unicompartmental knee arthroplasty (OUKA). This study examined where the fracture lines arises and evaluated the keel-cortex distances (KCDs) using three-dimensional computed tomography (3D-CT) and the effects of technical error (assessed by tibial component positions) and proximal tibial morphology on the KCDs. METHODS: This retrospective study included 217 OUKAs with cementless tibial components. Fifteen patients had tibial fractures after surgery. Anterior and posterior KCDs and fracture line origins were assessed using 3D-CT postoperatively. Proximal tibial morphology was assessed using the medial eminence line (MEL), which runs parallel to the tibial axis and passes through the tip of the medial intercondylar eminence of the tibia on long-leg anteroposterior radiograph. Knees had overhanging medial tibial condyle if the MEL passed medially to the medial tibial cortex. KCDs were compared between patients with/without fractures. Tibial component positions were evaluated, considering effects of tibial morphologies and component positions on fracture prevalence and KCDs. RESULTS: Fracture lines were found between the keel and posterior cortex in 12/15 patients. Posterior KCDs were significantly shorter in patients with fractures than in patients without (2.7 ± 1.6 mm vs 5.2 ± 1.7 mm, P < 0.001). Patients with medial overhanging condyles were more likely to have fracture (10/51 vs 5/166, P < 0.001) and had significantly shorter posterior KCD than those without (3.6 ± 1.5 mm vs 5.5 ± 1.8 mm, P < 0.001). Patients with tibial component that was set too medial, low, and valgus had higher rates of fracture than those without (7/39 vs 8/178, P = 0.008). Medial (r = 0.30, P < 0.001), low (r = -0.33, P < 0.001), and valgus implantations (r = 0.35, P < 0.001) of tibial components were related to shorter posterior KCDs. CONCLUSION: Short posterior KCD after OUKA is a risk factor for postoperative tibial fracture. Patients with either malposition of the tibial component (too medial, low, and valgus) and/or a medial overhanging condyle exhibit a shorter distance of posterior KCD and higher rate of fracture. LEVEL OF EVIDENCE: Level III.

  Apr. 2021, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 30(4) (4), 1220 - 1230, English, International magazine

  Scientific journal


• Accuracy of cup position following robot-assisted total hip arthroplasty may be associated with surgical approach and pelvic tilt.

  Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Kazunari Ishida, Nao Shibanuma, Tomoyuki Kamenaga, Ryosuke Kuroda

  This study aimed to investigate the accuracy of cup placement and determine the predictive risk factors for inaccurate cup positioning in robot-assisted total hip arthroplasty (THA). We retrospectively analyzed 115 patients who underwent robot-assisted THA between August 2018 and November 2019. Acetabular cup alignment and three-dimensional (3D) position were measured using pre- or postoperative computed tomography (CT) data. Absolute differences in cup inclination, anteversion, and 3D position were assessed, and their relation to preoperative factors was evaluated. The average measurement of the absolute differences was 1.8° ± 2.0° (inclination) and 1.9° ± 2.3° (anteversion). The average absolute difference in the 3D cup position was 1.1 ± 1.2 mm (coronal plane) and 0.9 ± 1.0 mm (axial plane). Multivariate analysis revealed that a posterior pelvic tilt [odds ratio (OR, 1.1; 95% confidence interval (CI), 1.00-1.23] and anterior surgical approach (OR, 5.1; 95% CI, 1.69-15.38) were predictive factors for inaccurate cup positioning with robot-assisted THA. This is the first study to demonstrate the predictive risk factors (posterior pelvic tilt and anterior surgical approach) for inaccurate cup position in robot-assisted THA.

  Apr. 2021, Scientific reports, 11(1) (1), 7578 - 7578, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Early postoperative clinical recovery of robotic arm-assisted vs. image-based navigated Total hip Arthroplasty.

  Nao Shibanuma, Kazunari Ishida, Tomoyuki Matsumoto, Koji Takayama, Yutaro Sanada, Masahiro Kurosaka, Ryosuke Kuroda, Shinya Hayashi

  BACKGROUND: This study compared the early clinical recovery of total hip arthroplasty (THA) using computer navigation systems (nTHA) and robotic arm-assisted THA (rTHA). METHODS: Thirty prospective subjects who underwent rTHA were clinically compared to 30 subjects who underwent nTHA. Clinical data (surgical time, intraoperative blood loss, pain severity, number of days to independent walking, and Harris Hip Score (HHS) at discharge), and radiographic parameters (inclination and anteversion angles) were statistically compared between the two groups. RESULTS: Follow-up times were 24.3 ± 6.0 and 27.0 ± 7.0 days in the rTHA and nTHA groups, respectively. The surgical time (135.1 ± 13.9 min vs. 146.2 ± 12.8 min, p = 0.002), number of days to independent walking (7.2 ± 2.0 vs. 11.5 ± 3.0 days, p < 0.001), and postoperative pain using a numeric rating scale on postoperative days 7, 10,, and 14 (1.4 ± 0.9 vs. 2.2 ± 1.2, p = 0.005; 1.0 ± 0.8 vs. 1.8 ± 1.1, p = 0.002; 0.3 ± 0.5 vs. 1.1 ± 0.9, p < 0.001; respectively) were significantly reduced in the rTHA group compared to the nTHA group. The rTHA group showed a significantly higher postoperative HHS compared to the nTHA group (85.3 ± .3.2 vs. 81.0 ± 8.5, p = 0.014). No statistically significant difference was observed in radiographic parameters between the groups; however, the incidence of intraoperative target angle changes was significantly lower in the rTHA group than in the nTHA group (0/30 subjects [0%] vs. 11/30 subjects [36.7%], p < 0.001). CONCLUSION: The surgical time, postoperative pain, and number of days to independent walking were significantly shorter, and the HHS at discharge was significantly higher in the rTHA group than in the nTHA group. Thus, compared to the nTHA group, the rTHA group showed improved early clinical recovery.

  Mar. 2021, BMC musculoskeletal disorders, 22(1) (1), 314 - 314, English, International magazine

  Scientific journal


• 生物学的製剤を使用中の関節リウマチ患者における単純ヘルペスおよび帯状疱疹ヘルペスの発症リスクを予測する新規バイオマーカーの同定

  橋本 麿和, 舟橋 惠子, 積山 賢, 菊池 健一, 藤田 雅広, 高島 良典, 前田 俊恒, 福田 康治, 林 申也, 佐川 昭, 松野 博明, 泉原 智麿, 生野 英祐, 都留 智巳, 織部 元廣, 松原 司

  (一社)日本リウマチ学会, Mar. 2021, 日本リウマチ学会総会・学術集会プログラム・抄録集, 65回, 701 - 701, Japanese


• A genome-wide association study identifying the SNPs predictive of rapid joint destruction in patients with rheumatoid arthritis.

  Shinya Hayashi, Tsukasa Matsubara, Koji Fukuda, Toshihisa Maeda, Keiko Funahashi, Marowa Hashimoto, Tomoyuki Kamenaga, Yoshinori Takashima, Ryosuke Kuroda

  Rheumatoid arthritis (RA) is a common chronic autoimmune disease leading to joint destruction. The aim of the present study was to identify the genomic factors predictive of susceptibility to joint destruction in patients with RA by performing a genome-wide association study of genetic variants, including single nucleotide polymorphisms (SNPs). The study sample included 228 patients with a diagnosis of RA in the past 5 years. Patients were classified into rapid (total Sharp score/years of RA, ≥50) and slow (total Sharp score/years of RA, <50) joint destruction groups for analysis. The association between the genome-wide SNP analysis and joint destruction was evaluated. The following SNPs were strongly associated with rapid radiographic joint destruction: rs2295926 (P<1x10-7), belonging to the N-acetylgalactosaminyltransferase 12 (GALNT12) gene and rs11958855 (P<1x10-6), belonging to the KCNN2 gene (associated with the potassium calcium-activated channel subfamily). The identification of genetic predictors of rapid joint destruction in RA (GALNT12 and KCNN2) may provide information regarding potential therapeutic targets, and this information may be used to assist in the management RA disease progression, thereby improving the functional outcomes for patients.

  Mar. 2021, Biomedical reports, 14(3) (3), 31 - 31, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Cryopreserved human adipose-derived stromal vascular fraction maintains fracture healing potential via angiogenesis and osteogenesis in an immunodeficient rat model.

  Tomoyuki Kamenaga, Yuichi Kuroda, Kanto Nagai, Masanori Tsubosaka, Yoshinori Takashima, Kenichi Kikuchi, Masahiro Fujita, Kemmei Ikuta, Kensuke Anjiki, Toshihisa Maeda, Naoki Nakano, Koji Takayama, Shingo Hashimoto, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: Novel therapeutic strategies for the healing of nonunion, which has serious effects on the quality of life of patients, are needed. We evaluated the therapeutic effect of local transplantation of human stromal vascular fraction (SVF) cells on fracture healing in a rat non-healing fracture model and compared the effects between freshly isolated (F) and cryopreserved (C)-SVFs. METHODS: Non-healing fracture model was induced in the femur of female immunodeficient rats (F344/N Jcl rnu/rnu) with cauterizing periosteum. Immediately after the creation of non-healing fracture, rats received local transplantation of F and C-SVFs suspended in phosphate-buffered saline (PBS) or the same volume of PBS without cells using the same scaffold as a control group. During 8 weeks post-surgery, radiologic, histological, immunohistochemical, and biomechanical analyses were performed to evaluate fracture healing. The comparison of radiological results was performed with a chi-square test, and the multiple comparisons of immunohistochemical, histological, and biomechanical results among groups were made using a one-way analysis of variance. A probability value of 0.05 was considered to denote statistical significance. RESULTS: At week 8, in 60% of animals receiving F-SVF cells and in 50% of animals receiving C-SVF cells, the fracture radiologically healed with bone union whereas nonunion was observed in the control group. The healing potential was also confirmed by histological and biomechanical assessments. One of the mechanisms underlying healing involving intrinsic angiogenesis/osteogenesis was enhanced in F- and C-SVF groups compared with that in the control group. Human cell-derived vasculogenesis/osteogenesis, which was also confirmed in an in vitro differentiation assay, was also enhanced in the F- and C-SVF groups compared with that in the control groups and could be another mechanism for healing. CONCLUSIONS: SVF cells can enhance bone healing and cryopreserved cells have almost equal potential as fresh cells. SVF cells can be used for improving nonunion bone fracture healing as an alternative to other mesenchymal stem cells and the effect of SVF cells can be maintained under cryopreservation.

  Feb. 2021, Stem cell research & therapy, 12(1) (1), 110 - 110, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Mid-flexion stability in the anteroposterior plane is achieved with a medial congruent insert in cruciate-retaining total knee arthroplasty for varus osteoarthritis.

  Masanori Tsubosaka, Kazunari Ishida, Kazuki Kodato, Nao Shibanuma, Shinya Hayashi, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: This study aimed to compare the intraoperative kinematics, especially for mid-flexion femorotibial anteroposterior (AP) stability, between newly developed medial congruent (MC) inserts and cruciate-retaining (CR) inserts in navigated cruciate-retaining total knee arthroplasty (CR-TKA). METHODS: Thirty consecutive patients with varus osteoarthritis undergoing CR-TKA using an image-free navigation system were enrolled. AP kinematics, the AP translation under manual maximum stress to the knee joint at 45° flexion, rotational kinematics, and varus-valgus laxity were evaluated using a navigation system and statistically compared between the MC and CR inserts. RESULTS: AP kinematic analysis showed that the femoral position with the CR insert was significantly anterior at a maximum extension to 45° flexion compared with the MC insert (p < 0.05). The amount of AP translation at 45° flexion with the MC insert was significantly smaller than that with the CR insert (p < 0.05). Rotational kinematics found that the tibial position at maximum extension was significantly externally rotated with the MC inserts than with the CR inserts. Varus-valgus laxity was comparable between the MC and CR inserts. CONCLUSION: The current results showed that greater mid-flexion AP stability was achieved with the MC inserts than with the CR inserts in CR-TKA. Intraoperative kinematics with the MC inserts more closely resembled those with preoperative conditions in CR-TKA. LEVEL OF EVIDENCE: III, prospective comparative study.

  Feb. 2021, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 29(2) (2), 467 - 473, English, International magazine

  Scientific journal


• Conventional computed tomography software can be used for accurate pre-operative templating in bipolar hip arthroplasty: A preliminary report.

  Nobuaki Chinzei, Mitsuaki Noda, Hiroshi Nashiki, Takehiko Matsushita, Atsuyuki Inui, Shinya Hayashi

  Background: The aim of this study was to investigate the use of pre-operative templating for bipolar hip arthroplasty (BHA) for displaced femoral neck fracture using multiplanar reconstruction (MPR) of computed tomography (CT) images. Methods: Nineteen patients who underwent BHA were enrolled in this study. For pre- and post-operative evaluation, a CT scan was performed from the pelvis to the knee joints. MPR of the CT image was done using software to measure the femoral head cup diameter, offset, stem size, length of the modular neck, distance from the neck osteotomy, and femoral anteversion. We compared these parameters pre- and post-operatively. Results: Both the femoral head cup diameter and length of the modular neck were found to be significantly different between pre- and post-operative measurements, although the differences were minor. Other parameters, including the femoral offset, were not significantly different between the pre- and post-operative measurements. The size of the femoral stem, cup diameter, and length of the modular neck were consistent with the planned size and accurate (within ±1 size) in more than 84% cases. Conclusion: Our pre-operative templating approach for BHA using MPR of CT has potential clinical utility as a complementary tool for pre-operative planning using three-dimensional templating software. Moreover, this technique could be feasible in most hospitals without additional expenditure.

  Feb. 2021, Journal of clinical orthopaedics and trauma, 13, 1 - 8, English, International magazine

  Scientific journal


• A Case of Femoral Neck Insufficiency Fracture due to Tumor-Induced Osteomalacia.

  Yu Inoue, Tomoaki Fukui, Keisuke Oe, Shinya Hayashi, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Tumor-induced osteomalacia (TIO) is a rare skeletal disease caused by hypersecretion of fibroblast growth factor 23 (FGF-23) from neoplasms of mesenchymal origin; patients with TIO present with insufficiency fractures, progressive bone pain, and delayed fracture unions. Herein, we report the case of a 48-year-old man with an insufficiency fracture in his left femoral neck associated with TIO. The causative tumor located in the patient's maxillary sinus had been resected; however, complete resection was impossible due to the location of the tumor. Therefore, the patient's osteomalacia persisted, and he experienced a left femoral neck fracture in the absence of severe trauma. Because delayed fracture union was anticipated in this patient, we performed an internal fixation using an implant with a lateral plate for angular stability and multiple screws for rotational stability. Although fracture union took 15 months, the patient's postoperative course was uneventful, and he could walk without any symptoms or assistance at his most recent follow-up 30 months after surgery. In TIO, hypersecretion of FGF-23 leads to increased renal excretion of phosphorus, increased bone resorption of calcium and phosphorus, decreased osteoblastic bone mineralization, and decreased gastrointestinal absorption of calcium and phosphorus, leading to insufficiency fractures and delayed fracture unions. Diagnosis of TIO is often delayed due to its rarity and vague symptoms. Total resection of the causative tumor is the optimal treatment; however, in cases wherein complete tumor resection is impossible, drug therapy may be insufficient, and the underlying TIO pathology, including bone fragility, may persist. Early diagnosis of TIO is important for preventing insufficiency fractures; however, when fractures are unavoidable, the surgical treatment of femoral neck fractures in patients with osteomalacia should account for a longer time frame for complete fracture union and therefore utilize implants with sufficient stability.

  2021, Case reports in orthopedics, 2021, 6668006 - 6668006, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Comparison between Single- and Multi-Radius Prostheses Used in Modified Kinematically Aligned Cruciate-Retaining Total Knee Arthroplasty.

  Tomoyuki Matsumoto, Yoshinori Takashima, Koji Takayama, Kazunari Ishida, Naoki Nakano, Yuichi Kuroda, Masanori Tsubosaka, Tomoyuki Kamenaga, Takehiko Matsushita, Takahiro Niikura, Shinya Hayashi, Ryosuke Kuroda

  Kinematically aligned total knee arthroplasty (TKA) has gained interest for achieving more favorable clinical outcomes than mechanically aligned TKA. The present study aimed to compare the clinical outcomes of kinematically aligned TKAs using single-radius (SR) or multi-radius (MR) prostheses. Sixty modified kinematically aligned cruciate-retaining TKAs (30 SR and 30 MR type prostheses) were performed in patients with varus-type osteoarthritis using a navigation system. Intraoperative and postoperative patellar tracking were compared between the two groups. Trochlea shape was also compared between the prostheses and preoperative native anatomy using three-dimensional simulation software. Total 2 years postoperatively, the range of motion and 2011 Knee Society Scores (KSS) were compared between the two groups. There were no differences in patellar maltracking including patellar lateral shift and tilt between the two groups; however, the ratio of intraoperative lateral retinacular release for adjusting patellar tracking was significantly higher in the MR group than in the SR group. Lateral and medial facet heights in both prostheses were understuffed compared with native knee anatomy, while the deepest point of the trochlear groove was significantly more medial in the MR group. The postoperative clinical outcomes showed no significant differences between the two groups. In conclusion, modified kinematically aligned TKAs using a SR or MR prosthesis showed no significant differences in clinical outcomes or patellar tracking when appropriate lateral retinacular release was performed.

  Dec. 2020, The journal of knee surgery, English, International magazine

  Scientific journal


• Effectiveness of an accelerometer-based portable navigation for intraoperative adjustment of leg length discrepancy in total hip arthroplasty in the supine position.

  Kensuke Anjiki, Tomoyuki Kamenaga, Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Takaaki Fujishiro, Takafumi Hiranaka, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: This study aimed to examine the accuracy of the HipAlign® accelerometer-based portable navigation system by measuring the intraoperative leg length change of patients who underwent total hip arthroplasty (THA) and comparing the measured leg length discrepancy (LLD) determined by the navigation system and a freehand technique. METHODS: A total of 61 patients who underwent THA using the anterolateral approach in the supine position were included in this study and divided into two groups: those who underwent THA with navigation (Group N; N = 31) and with the freehand technique (Group F; N = 30). Statistical analyses were performed to compare the intraoperative leg length change, pre- and post-LLD, absolute values of post-LLD, and the number of patients with the postoperative LLD within 10 mm and 5 mm between the two groups. Additionally, we examined the correlation between the leg length change obtained through intraoperative navigation and measured from the radiographs. Moreover, to evaluate the navigation accuracy, we examined the correlation between the absolute error of leg length change and cup orientation. RESULTS: The postoperative LLD was significantly lower and the number of patients with the postoperative LLD within 5 mm was significantly higher in Group N, compared with Group F. Additionally, the amount of leg length change measured intraoperatively by the navigation system was strongly correlated with the values obtained by the postoperative radiographic measurement with a small absolute error and minimal wasted time. Moreover, a significant positive correlation was found between the absolute error of the leg length change and that of the cup inclination. CONCLUSIONS: Our study demonstrates that the accelerometer-based portable navigation system is useful for the intraoperative adjustment of leg length discrepancy during THA for patients in the supine position, as it provides good accuracy and minimizes required time for use.

  Dec. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 27(1) (1), 169 - 175, English, Domestic magazine

  Scientific journal


• Risk factors of thigh pain following total hip arthroplasty with short, tapered-wedge stem.

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Takahiro Niikura, Ryosuke Kuroda

  PURPOSE: The occurrence of thigh pain following cementless total hip arthroplasty (THA) may be dependent on multiple factors, which may differ with design of the prosthesis. Thus, this study aimed to investigate the frequency of thigh pain following cementless THA using a short, tapered-wedge stem to identify risk factors for thigh pain. METHODS: This retrospective cohort study analysed 222 joints of patients who underwent THA with a short, tapered-wedge stem. Thigh pain was evaluated using a questionnaire during each follow-up visit, and the clinical and radiographic assessments were compared. RESULTS: Thigh pain occurred in 37 patients (16.7%) during the follow-up period. The pain started two to 24 months after THA. Multivariate analysis demonstrated that higher University of California, Los Angeles, activity rating (odds ratio 7.2; 95% confidence interval (CI) 3.0-17.2); Dorr type C femoral bone shape (odds ratio 1.5; 95% CI 1.1-2.0); and stem tip-cortical bone contact (odds ratio 8.2; 95% CI 2.3-29.4) were significant risk factors of thigh pain following THA. Post-operatively, cortical hypertrophy at Gruen zone 4 was significantly found in patients with thigh pain (p value = 0.032). CONCLUSION: Risk factors of pain following THA with short, tapered-wedge stem were high activity level, Dorr type C femoral bone shape, and stem tip contacting the distal bone surface. Moreover, post-operative cortical hypertrophy at the distal stem tip significantly increased the incidence of thigh pain. Therefore, we must pay attention to the aforementioned factors to avoid post-operative thigh pain when using a short, tapered-wedge stem.

  Dec. 2020, International orthopaedics, 44(12) (12), 2553 - 2558, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Extent of in vivo sagittal bearing movement and its relationship with tibial posterior slopes in Oxford mobile-bearing unicompartmental knee arthroplasty.

  Tomoyuki Kamenaga, Yuichi Hida, Takafumi Hiranaka, Toshikazu Tanaka, Kenjiro Okimura, Masanori Tsubosaka, Yuichi Kuroda, Naoki Nakano, Shinya Hayashi, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: The effect of increased tibial slope on the bearing movement and clinical results in mobile-bearing unicompartmental knee arthroplasty has not been well discussed. We aimed to clarify the extent of in vivo sagittal bearing movement and bearing overhang using fluoroscopy and their relationship with the tibial posterior slopes and clinical results. METHODS: This retrospective study included 40 patients who underwent Oxford unicompartmental knee arthroplasty for anteromedial osteoarthritis or osteonecrosis of the knee. Intraoperative posterior translation and posterior overhang of the bearing were assessed during flexion. The tibial posterior slopes were evaluated before and 2 weeks after surgery, and its increment was recorded. Clinical evaluations were also performed preoperatively and at 2 years postoperatively (maximum flexion angle, Oxford Knee Score). Single linear regression analysis was performed to assess the correlation between the tibial posterior slopes and the posterior translation and the posterior overhang and determine if these could affect the clinical outcomes. FINDINGS: The average posterior translation was 10.7 ± 4.3 mm, and posterior overhang of the mobile bearing was found in 35% of overall patients. They were associated with increased tibial slope as well as poorer improvement in Oxford Knee Score at 2 years postoperatively. INTERPRETATION: In Oxford unicompartmental knee arthroplasty, mobile bearing can probably move posteriorly beyond the posterior margin of the tibial component during flexion when the tibial posterior slope increases more than the original magnitude. Additionally, the posterior translation and posterior overhang closely correlated with the poorer improvement in Oxford Knee Score at 2 years postoperatively.

  Dec. 2020, Clinical biomechanics (Bristol, Avon), 80, 105148 - 105148, English, International magazine

  Scientific journal


• Transcutaneous CO2 application accelerates fracture repair in streptozotocin-induced type I diabetic rats.

  Takahiro Oda, Takahiro Niikura, Tomoaki Fukui, Keisuke Oe, Yu Kuroiwa, Yohei Kumabe, Kenichi Sawauchi, Ryo Yoshikawa, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Teruya Kawamoto, Yoshitada Sakai, Toshihiro Akisue, Ryosuke Kuroda

  INTRODUCTION: Diabetes mellitus (DM) negatively affects fracture repair by inhibiting endochondral ossification, chondrogenesis, callus formation, and angiogenesis. We previously reported that transcutaneous CO2 application accelerates fracture repair by promoting endochondral ossification and angiogenesis. The present study aimed to determine whether CO2 treatment would promote fracture repair in cases with type I DM. RESEARCH DESIGN AND METHODS: A closed femoral shaft fracture was induced in female rats with streptozotocin-induced type I DM. CO2 treatment was performed five times a week for the CO2 group. Sham treatment, where CO2 was replaced with air, was performed for the control group. Radiographic, histologic, genetic, and biomechanical measurements were taken at several time points. RESULTS: Radiographic assessment demonstrated that fracture repair was induced in the CO2 group. Histologically, accelerated endochondral ossification and capillary formation were observed in the CO2 group. Immunohistochemical assessment indicated that early postfracture proliferation of chondrocytes in callus was enhanced in the CO2 group. Genetic assessment results suggested that cartilage and bone formation, angiogenesis, and vasodilation were upregulated in the CO2 group. Biomechanical assessment revealed enhanced mechanical strength in the CO2 group. CONCLUSIONS: Our findings suggest that CO2 treatment accelerates fracture repair in type I DM rats. CO2 treatment could be an effective strategy for delayed fracture repair due to DM.

  Dec. 2020, BMJ open diabetes research & care, 8(2) (2), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Central Implantation of the Femoral Component Relative to the Tibial Insert Improves Clinical Outcomes in Fixed-Bearing Unicompartmental Knee Arthroplasty.

  Tomoyuki Kamenaga, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: The direct relationship between clinical outcomes and femoral component positioning relative to a tibial insert remains unknown. We determined whether the femoral component position relative to the tibial insert could affect clinical outcomes after fixed-bearing unicompartmental knee arthroplasty (UKA). METHODS: The femoral component position relative to the tibial insert of 66 patients with anteromedial osteoarthritis and osteonecrosis of the knee who underwent fixed-bearing UKA was assessed at 2 weeks postoperatively. We classified patients according to the contact point of the femoral component with the tibial component: group M (medial), 18 knees; group C (central), 30 knees; and group L (lateral), 18 knees. Patient-derived clinical scores using the 2011 Knee Society Score were also assessed preoperatively and at 2 years postoperatively and compared among the 3 groups using the analysis of variance. RESULTS: The average 2-year postoperative "symptom" and "patient satisfaction" scores based on the 2011 Knee Society Score were significantly higher in group C than in group M or group L. CONCLUSION: Central implantation of the femoral component relative to the tibial insert plays an important role in decreasing pain and could result in better patient satisfaction after fixed-bearing UKA at 2 years postoperatively. Surgeons should set the femoral component at the center relative to the tibial insert for better patient satisfaction and higher active knee flexion after fixed-bearing UKA.

  Nov. 2020, The Journal of arthroplasty, 35(11) (11), 3108 - 3116, English, International magazine

  Scientific journal


• Preoperative Condition of the Patellofemoral Joint Does Not Negatively Impact Surgical Outcomes of Lateral Unicompartmental Knee Arthroplasty in the Short Term.

  Masahiro Fujita, Takafumi Hiranaka, Tomoyuki Kamenaga, Masanori Tsubosaka, Naoki Nakano, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  The relationship between patellofemoral joint (PFJ) degeneration and clinical outcomes following lateral unicompartmental knee arthroplasty (UKA) has not been well described thus far. This study aimed to investigate the relationship between the preoperative PFJ condition and postoperative outcomes and the changes in lower-limb and PFJ alignment after lateral UKA. This was a retrospective study including 54 patients (mean age 72.9 years) who underwent lateral UKA for isolated lateral knee osteoarthritis at our institution between March 2013 and January 2019. The Oxford Knee Score (OKS), the Knee Society Score-Knee (KSSK), and Knee Society Score-Function (KSSF), the degree of degeneration, tilting angle and lateral shift of the PFJ, and the hip-knee-ankle angle (HKA) were evaluated pre- and postoperatively. The average follow-up period was 2.8 (range 1-6.1) years. There was a significant improvement in the OKS, KSSK, and KSSF after lateral UKA. Preoperative degeneration of the PFJ did not correlate with the recovery of clinical scores. The degeneration, tilting angle, and lateral shift of the PFJ did not significantly progress following lateral UKA. The HKA was improved after lateral UKA, and there was no correlation between the HKA change and PFJ condition. Postoperative severe valgus knee alignment was associated with a greater tilting angle. Preoperative degeneration of the PFJ did not have a negative impact on postoperative outcomes, and no short-term changes in the degeneration, tilting angle, and lateral shift of the PFJ were observed. Correction of knee-joint alignment did not have a negative impact on the condition of the PFJ.

  Oct. 2020, The journal of knee surgery, 35(7) (7), 810 - 815, English, International magazine

  Scientific journal


• Predictive factors for effective selection of Interleukin-6 inhibitor and tumor necrosis factor inhibitor in the treatment of rheumatoid arthritis.

  Shinya Hayashi, Tsukasa Matsubara, Koji Fukuda, Keiko Funahashi, Marowa Hashimoto, Toshihisa Maeda, Tomoyuki Kamenaga, Yoshinori Takashima, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda

  Treatment of rheumatoid arthritis (RA) is aimed at long-term remission and inhibition of joint destruction by different biologic drugs. However, the choice of a particular biologic agent based on individual cases of RA remains unestablished. Interleukin-6 (IL-6) inhibitor and tumor necrosis factor (TNF) inhibitor are common biologics used for the treatment of RA. This study aimed to investigate predictive factors for effective selection of tocilizumab (IL-6 inhibitor) and etanercept (TNF inhibitor) in patients with RA. This is a retrospective cohort study. The 196 patients analyzed in this study were divided into four groups: tocilizumab treatment as the first biologic group (TCZ first, 42 patients), tocilizumab as second/ third biologic group (TCZ second, 34 patients), etanercept as the first biologic group (ETN first, 103 patients) and etanercept as second/third group (ETN second, 17 patients). Visual analog scale (VAS), clinical disease activity index (CDAI), and modified health assessment questionnaire (mHAQ) scores at the initiation of biologic treatment and after 6 months of tocilizumab and etanercept therapy were measured and compared to clinical parameters and radiographical parameters among the four groups. CRP, MMP-3, VAS, CDAI, and HAQ were improved after 6 months of treatment in all groups. Improvement of clinical outcomes was correlated with CRP value, duration of RA, and Sharp scores at the initiation of treatment. Multivariate analysis demonstrated improvement in CDAI was significantly associated with the yearly progression of erosion according to the Sharp score in TCZ first group (OR, 1.5; 95% CI, 1.03-2.07) and was negatively associated with the duration of RA (OR, 0.49; 95% CI, 0.29-0.86) at the initiation of treatment with ETN first group. We identified the predictive factors for effective selection of tocilizumab and etanercept treatment and established the effectiveness of tocilizumab for the patients with rapid progressive joint erosion and etanercept for the early administration from diagnosis of RA.

  Oct. 2020, Scientific reports, 10(1) (1), 16645 - 16645, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Varus deformity in the proximal tibia and immediate postoperative varus alignment result in varus progression in limb alignment in the long term after total knee arthroplasty.

  Yuichi Kuroda, Koji Takayama, Shinya Hayashi, Shingo Hashimoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: The aim of this study was to examine and evaluate the factors associated with changes in limb alignment 10 years after total knee arthroplasty (TKA). The hypothesis was that bone morphology and immediate postoperative alignment could be correlated with long-term post-operative alignment changes following TKA. METHODS: This study retrospectively analysed 136 consecutive primary TKA cases for varus deformity, performed from 2006 to 2008, that could be followed for at least 10 years postoperatively. Anteroposterior long-leg weight-bearing radiographs were obtained within 1 month and at least 10 years after surgery. The hip-knee-ankle (HKA) angle immediately after surgery was compared with that 10 years later; factors correlating with the change in HKA angle (δHKA) were evaluated. RESULTS: The mean HKA angles were significantly different between immediate and long-term postoperative assessments (0.1° ± 1.9° vs. 1.2° ± 2.9°, p < 0.001). Furthermore, a significant difference was observed in the outlier ratio (> 3° deviation from the 0° of HKA angle) (10% vs. 24%, p = 0.002). δHKA strongly correlated with a higher preoperative tibial plateau tip-to-proximal tibial shaft (TPTPS) angle, higher postoperative HKA angle, lateral distal femoral angle, and lower postoperative medial proximal tibial angle. CONCLUSION: Varus deformity in the proximal part of the tibia, immediate postoperative varus alignment, and varus position of the femoral and tibial components may lead to varus progression in limb alignment in the long term, even 10 years after TKA; the surgeon should, therefore, weigh the risks of leaving a varus alignment during surgery. Moreover, if the preoperative TPTPS angle is high, the alignment may become varus after TKA, even in patients who have acquired neutral alignment. LEVEL OF EVIDENCE: IV.

  Oct. 2020, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 28(10) (10), 3287 - 3293, English, International magazine

  Scientific journal


• Larger Acetabular Labrum Is Associated With Hip Dysplasia, Joint Incongruence, and Clinical Symptoms.

  Tomoyuki Kamenaga, Shingo Hashimoto, Shinya Hayashi, Koji Takayama, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: To evaluate the association of labral length with acetabular morphology and clinical symptoms. METHODS: Patients treated at our hip joint clinic between January 2015 and December 2018 were retrospectively enrolled in the study. Our sample included patients who received a diagnosis of one or more of the following: hip labral tear, femoroacetabular impingement (FAI), and developmental dysplasia of the hip. Patients with osteoarthritis and/or osteonecrosis were excluded. Bilateral labral length was measured as the distance from the acetabular rim to the edge of the labrum at the level of the central coronal T1-weighted magnetic resonance imaging scan cross-referenced to the axial plane (3- to 9-o'clock position). The lateral center-edge angle (LCEA) and acetabular roof obliquity (ARO) were evaluated with plain radiographs. An LCEA of 25° or less was defined as developmental dysplasia of the hip, whereas a positive crossover sign in the presence of an LCEA of 30° or greater, an LCEA greater than 40°, or acetabular inclination lower 0° was defined as pincer FAI. An alpha angle greater than 50° or head-neck offset lower 8 mm was considered cam FAI. The severity of hip symptoms was evaluated bilaterally using the Japanese Orthopaedic Association pain scale, on which hips scoring full points (i.e., a perfect score) were defined as asymptomatic whereas hips with all other scores were considered symptomatic. We used simple linear regression to examine the correlations of labral length with the LCEA and ARO. Labral length was also compared according to patient hip symptom status using the Mann-Whitney U test. RESULTS: The study included 102 patients (14 with bilateral symptoms and 88 with unilateral symptoms). Labral length was strongly correlated with the LCEA (r = -0.612, P < .001) and ARO (r = 0.635, P < .001). Additionally, patients with symptomatic hips had significantly larger labra (9.5 ± 3.0 mm) than those with asymptomatic hips (7.9 ± 2.1 mm, P = .004). CONCLUSIONS: Acetabular labral length is significantly greater in dysplastic, irregularly congruent, symptomatic hips. LEVEL OF EVIDENCE: Level Ⅳ, retrospective cross-sectional study.

  Sep. 2020, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 36(9) (9), 2446 - 2453, English, International magazine

  Scientific journal


• Preoperative anterior coverage of the medial acetabulum can predict postoperative anterior coverage and range of motion after periacetabular osteotomy: a cohort study.

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Tomoyuki Kamenaga, Takahiro Niikura, Ryosuke Kuroda

  BACKGROUND: We hypothesized that preoperative pelvic morphology may affect postoperative anterior coverage and postoperative clinical range of motion (ROM) leading to postoperative pincer type femoroacetabular impingement (FAI). The aim of this study was to evaluate the relationships between preoperative bone morphology and postoperative ROMs to prevent postoperative FAI after periacetabular osteotomy. METHODS: Sixty-eight patients (71 hips) with hip dysplasia participated in this study and underwent curved PAO. The acetabular fragment was usually moved only by lateral rotation of the acetabulum, without intraoperative anterior or posterior rotation. The pre- and postoperative three-dimensional center-edge (CE) angles were measured and compared to the postoperative ROM. RESULTS: Preoperative medial anterior CE angle was significantly associated with postoperative anterior CE angle, and the correlation coefficient of medial anterior CE and postoperative anterior CE was higher than the coefficient of preoperative anterior CE and postoperative anterior CE (preoperative anterior CE, rr = 0.27, p = 0.020; preoperative medial anterior CE, rr = 0.54, p < 0.001). Femoral anteversion correlated with postoperative internal rotation angle at 90° flexion (r = 0.32, p = 0.021). In multiple linear regressions, postoperative internal rotation angle at 90° flexion angle was significantly affected by both medial CE angle through the medial one fourth of femoral head and femoral anteversion. CONCLUSIONS: Preoperative medial anterior acetabular coverage was associated with postoperative anterior acetabular coverage. Further, the combination with preoperative medial anterior acetabular coverage and femoral anteversion can predict postoperative internal rotation at 90° flexion. Therefore, the direction of acetabular reorientation should be carefully considered when the patients have high preoperative medial anterior CE angle and small femoral anteversion.

  Aug. 2020, Journal of orthopaedic surgery and research, 15(1) (1), 312 - 312, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Percutaneous CO2Treatment Accelerates Bone Generation during Distraction Osteogenesis in Rabbits

  Yohei Kumabe, Tomoaki Fukui, Shunsuke Takahara, Yu Kuroiwa, Michio Arakura, Keisuke Oe, Takahiro Oda, Kenichi Sawauchi, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  Aug. 2020, Clinical Orthopaedics and Related Research, 478(8) (8), 1922 - 1935

  Scientific journal


• Overcorrection of the acetabular roof angle or anterior center-edge angle may cause decrease of range of motion after curved periacetabular osteotomy.

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Tomoyuki Kamenaga, Takahiro Niikura, Ryosuke Kuroda

  The aim of this study was to evaluate the relationship between the correction of radiographic parameters and clinical range of motion (ROM) after periacetabular osteotomy (PAO). Sixty-nine patients with hip dysplasia were enrolled and underwent curved PAO. The pre- and post-operative 3D center-edge (CE) angles, total anteversion (acetabular and femoral anteversion), and radiographic acetabular roof angle were measured and compared with the post-operative ROM. The aim of surgery was to rotate the central acetabular fragment laterally without anterior or posterior rotation. Multiple linear regression analysis demonstrated that post-operative internal rotation at 90° flexion was significantly associated with the post-operative Tönnis sourcil angle (rr = 0.31, P = 0.02) and that the post-operative ROM of flexion and internal rotation at 90° flexion were significantly associated with the anterior CE (flex; rr = -0.44, P = 0.001, internal rotation at 90° flexion; rr = -0.44, P < 0.001). However, we found no association between the lateral CE, femoral anteversion, or total anteversion and the post-operative ROM. We demonstrated that the overcorrection of the acetabular roof angle or anterior CE angle may cause a decrease in the range of motion after curved PAO. Therefore, surgeons need to be careful during surgery to prevent the overcorrection of the weight-bearing area and anterior acetabular coverage of the acetabular fragment to avoid femoroacetabular impingement after PAO.

  Aug. 2020, Journal of hip preservation surgery, 7(3) (3), 583 - 590, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Percutaneous CO2 Treatment Accelerates Bone Generation During Distraction Osteogenesis in Rabbits.

  Yohei Kumabe, Tomoaki Fukui, Shunsuke Takahara, Yu Kuroiwa, Michio Arakura, Keisuke Oe, Takahiro Oda, Kenichi Sawauchi, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Distraction osteogenesis has been broadly used to treat various structural bone deformities and defects. However, prolonged healing time remains a major problem. Various approaches including the use of low-intensity pulsed ultrasound, parathyroid hormone, and bone morphogenetic proteins (BMPs) have been studied to shorten the treatment period with limited success. Our previous studies of rats have reported that the transcutaneous application of CO2 accelerates fracture repair and bone-defect healing in rats by promoting angiogenesis, blood flow, and endochondral ossification. This therapy may also accelerate bone generation during distraction osteogenesis, but, to our knowledge, no study investigating CO2 therapy on distraction osteogenesis has been reported. QUESTIONS/PURPOSES: We aimed to investigate the effect of transcutaneous CO2 during distraction osteogenesis in rabbits, which are the most suitable animal as a distraction osteogenesis model for a lengthener in terms of limb size. We asked: Does transcutaneous CO2 during distraction osteogenesis alter (1) radiographic bone density in the distraction gap during healing; (2) callus parameters, including callus bone mineral content, volumetric bone mineral density, and bone volume fraction; (3) the newly formed bone area, cartilage area, and angiogenesis, as well as the expression of interleukin-6 (IL-6), BMP-2, BMP-7, hypoxia-inducible factor (HIF) -1α, and vascular endothelial growth factor (VEGF); and (4) three-point bend biomechanical strength, stiffness, and energy? METHODS: Forty 24-week-old female New Zealand white rabbits were used according to a research protocol approved by our institutional ethical committee. A distraction osteogenesis rabbit tibia model was created as previously described. Briefly, an external lengthener was applied to the right tibia, and a transverse osteotomy was performed at the mid-shaft. The osteotomy stumps were connected by adjusting the fixator to make no gap. After a 7-day latency phase, distraction was continued at 1 mm per day for 10 days. Beginning the day after the osteotomy, a 20-minute transcutaneous application of CO2 on the operated leg using a CO2 absorption-enhancing hydrogel was performed five times per week in the CO2 group (n = 20). Sham treatment with air was administered in the control group (n = 20). Animals were euthanized immediately after the distraction period (n = 10), 2 weeks (n = 10), and 4 weeks (n = 20) after completion of distraction. We performed bone density quantification on the plain radiographs to evaluate consolidation in the distraction gap with image analyzing software. Callus parameters were measured with micro-CT to assess callus microstructure. The newly formed bone area and cartilage area were measured histologically with safranin O/fast green staining to assess the progress of ossification. We also performed immunohistochemical staining of endothelial cells with fluorescein-labeled isolectin B4 and examined capillary density to evaluate angiogenesis. Gene expressions in newly generated callus were analyzed by real-time polymerase chain reaction. Biomechanical strength, stiffness, and energy were determined from a three-point bend test to assess the mechanical strength of the callus. RESULTS: Radiographs showed higher pixel values in the distracted area in the CO2 group than the control group at Week 4 of the consolidation phase (0.98 ± 0.11 [95% confidence interval 0.89 to 1.06] versus 1.19 ± 0.23 [95% CI 1.05 to 1.34]; p = 0.013). Micro-CT demonstrated that bone volume fraction in the CO2 group was higher than that in the control group at Week 4 (5.56 ± 3.21 % [95% CI 4.32 to 6.12 %] versus 11.90 ± 3.33 % [95% CI 9.63 to 14.25 %]; p = 0.035). There were no differences in any other parameters (that is, callus bone mineral content at Weeks 2 and 4; volumetric bone mineral density at Weeks 2 and 4; bone volume fraction at Week 2). At Week 2, rabbits in the CO2 group had a larger cartilage area compared with those in the control group (2.09 ± 1.34 mm [95% CI 1.26 to 2.92 mm] versus 5.10 ± 3.91 mm [95% CI 2.68 to 7.52 mm]; p = 0.011). More newly formed bone was observed in the CO2 group than the control group at Week 4 (68.31 ± 16.32 mm [95% CI 58.19 to 78.44 mm] versus 96.26 ± 19.37 mm [95% CI 84.25 to 108.26 mm]; p < 0.001). There were no differences in any other parameters (cartilage area at Weeks 0 and 4; newly formed bone area at Weeks 0 and 2). Immunohistochemical isolectin B4 staining showed greater capillary densities in rabbits in the CO2 group than the control group in the distraction area at Week 0 and surrounding tissue at Weeks 0 and 2 (distraction area at Week 0, 286.54 ± 61.55 /mm [95% CI 232.58 to 340.49] versus 410.24 ± 55.29 /mm [95% CI 361.78 to 458.71]; p < 0.001; surrounding tissue at Week 0 395.09 ± 68.16/mm [95% CI 335.34 to 454.83] versus 589.75 ± 174.42/mm [95% CI 436.86 to 742.64]; p = 0.003; at Week 2 271.22 ± 169.42 /mm [95% CI 122.71 to 419.73] versus 508.46 ± 49.06/mm [95% CI 465.45 to 551.47]; p < 0.001 respectively). There was no difference in the distraction area at Week 2. The expressions of BMP -2 at Week 2, HIF1-α at Week 2 and VEGF at Week 0 and 2 were greater in the CO2 group than in the control group (BMP -2 at Week 2 3.84 ± 0.83 fold [95% CI 3.11 to 4.58] versus 7.32 ± 1.63 fold [95% CI 5.88 to 8.75]; p < 0.001; HIF1-α at Week 2, 10.49 ± 2.93 fold [95% CI 7.91 to 13.06] versus 20.74 ± 11.01 fold [95% CI 11.09 to 30.40]; p < 0.001; VEGF at Week 0 4.80 ± 1.56 fold [95% CI 3.43 to 6.18] versus 11.36 ± 4.82 fold [95% CI 7.13 to 15.59]; p < 0.001; at Week 2 31.52 ± 8.26 fold [95% CI 24.27 to 38.76] versus 51.05 ± 15.52 fold [95% CI 37.44 to 64.66]; p = 0.034, respectively). There were no differences in any other parameters (BMP-2 at Week 0 and 4; BMP -7 at Weeks 0, 2 and 4; HIF-1α at Weeks 0 and 4; IL-6 at Weeks 0, 2 and 4; VEGF at Week 4). In the biomechanical assessment, ultimate stress and failure energy were greater in the CO2 group than in the control group at Week 4 (ultimate stress 259.96 ± 74.33 N [95% CI 167.66 to 352.25] versus 422.45 ± 99.32 N [95% CI 299.13 to 545.77]; p < 0.001, failure energy 311.32 ± 99.01 Nmm [95% CI 188.37 to 434.25] versus 954.97 ± 484.39 Nmm [95% CI 353.51 to 1556.42]; p = 0.003, respectively). There was no difference in stiffness (216.77 ± 143.39 N/mm [95% CI 38.73 to 394.81] versus 223.68 ± 122.17 N/mm [95% CI 71.99 to 375.37]; p = 0.92). CONCLUSION: Transcutaneous application of CO2 accelerated bone generation in a distraction osteogenesis model of rabbit tibias. As demonstrated in previous studies, CO2 treatment might affect bone regeneration in distraction osteogenesis by promoting angiogenesis, blood flow, and endochondral ossification. CLINICAL RELEVANCE: The use of the transcutaneous application of CO2 may open new possibilities for shortening healing time in patients with distraction osteogenesis. However, a deeper insight into the mechanism of CO2 in the local tissue is required before it can be used in future clinical practice.

  Aug. 2020, Clinical orthopaedics and related research, 478(8) (8), 1922 - 1935, English, International magazine

  Scientific journal


• Soluble CD14 Induces Pro-inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-Like Synovial Cells via Toll-Like Receptor 4.

  Yoshihide Ichise, Jun Saegusa, Shino Tanaka-Natsui, Ikuko Naka, Shinya Hayashi, Ryosuke Kuroda, Akio Morinobu

  OBJECTIVES: Synovial fluids of rheumatoid arthritis (RA) patients commonly contain high concentrations of soluble CD14 (sCD14). To investigate its potential role in RA pathogenesis, we tested whether sCD14 binding transmits a signal to fibroblast-like synoviocytes from RA patients (RA-FLS). METHODS: The induction of pro-inflammatory cytokines, chemokines, and mediators by sCD14 stimulation of RA-FLS was quantified by real-time PCR and ELISA. Cell proliferation was assessed by the BrdU assay. LPS-RS, a Toll-like receptor 4 (TLR-4) antagonist, was used to block TLR-4 signaling. RESULTS: Soluble CD14 induced the expression of IL-6 mRNA and secretion of the protein. The expression of other pro-inflammatory cytokines and mediators, such as TNF-α, IL-8, intercellular adhesion molecule-1 (ICAM-1), MMP-3, and RANK ligand (RANKL), was also induced by sCD14. In addition, sCD14 stimulation promoted RA-FLS proliferation. LPS-RS abolished IL-6, IL-8, and ICAM-1 mRNA induction by sCD14 in RA-FLS. On the other hand, TNF-α and IL-17A increased TLR-4 expression by RA-FLS and amplified their sCD14-induced IL-6 expression. CONCLUSIONS: Soluble CD14 transmits inflammatory signals to RA-FLS via TLR-4. The effects of sCD14 may be augmented in inflammatory milieu. Our results suggest that sCD14 is involved in the pathogenesis of RA and may be a novel therapeutic target.

  Jul. 2020, Cells, 9(7) (7), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Predictors of Health-Related Quality of Life After Revision Total Hip Arthroplasty for Aseptic Loosening.

  Yuichi Kuroda, Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Ryosuke Kuroda

  Background: Few studies have investigated the relationships between preoperative or intraoperative patient factors and postoperative quality of life (QOL) after revision total hip arthroplasty (THA). The aim of our study was to identify the predictors of QOL after revision THA for aseptic loosening. Materials and Methods: Fifty-one patients who underwent revision THA for aseptic loosening were included in the present study. Preoperative hip function was evaluated using the Japanese Orthopaedic Association (JOA) score. The patients' QOL after surgery was evaluated with EuroQol 5D (EQ-5D) assessment at the end of the 2-year follow-up. The patients were then divided into two groups: good QOL (score ≥ 0.6) and poor QOL (score < 0.6). Predictive factors (i.e., age, BMI, preoperative JOA score, and the degree of acetabular bone defect according to the Paprosky classification) were compared between both QOL groups. Furthermore, multiple linear regression was performed to assess independent factors affecting the QOL. Results: Significant differences between the good and poor QOL groups were identified for BMI, walking ability, and severity of acetabular bone defect (BMI: 21.5 ± 2.9 vs. 24.1 ± 4.3, P = 0.0331; walking ability: 11.5 ± 5.0 vs. 5.5 ± 4.9, P = 0.0058; acetabular bone defect: 44.4% vs. 81.0%, P = 0.0103). The walking ability independently affected the EQ-5D utility score. Conclusions: The present study indicates that a higher BMI, lower walking ability, and more severe acetabular bone defect are predictors of lower QOL after revision THA for aseptic loosening. In particular, the walking ability was the only independent factor. Thus, surgeons should pay attention to the postoperative management of patients with these risk factors.

  Jul. 2020, Indian journal of orthopaedics, 54(4) (4), 463 - 468, English, International magazine

  Scientific journal


• Mobile-bearing insert reduced patellar contact force at knee flexion during posterior stabilized total knee arthroplasty.

  Yuichi Kuroda, Koji Takayama, Shinya Hayashi, Shingo Hashimoto, Masanori Tsubosaka, Tomoyuki Kamenaga, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: This study aimed to compare tibial rotation and patellar contact force between mobile- and fixed-bearing total knee arthroplasty from extension to flexion by using a navigation system and patellar contact force sensor on the same patients' knees. METHODS: Thirty-one consecutive patients who had undergone a primary posterior stabilized total knee arthroplasty were included. Patellar contact forces on the medial and lateral sides were measured at each flexion angle, and tibial rotation was assessed during 30-90°, and 90-120° knee flexion. The patellar contact force and tibial rotation were measured twice with the mobile- and fixed-platform trial components and compared between the two groups. FINDINGS: The patellar contact force was significantly lower with mobile than with fixed-bearing total knee arthroplasty on the medial side at 120° flexion (P = .0138) and lateral side at 60°, 90°, and 120° flexion (P = .0346, P = .0127, and P = .0376). There were no significant differences in tibial rotation between the mobile- and fixed-bearing inserts during both 30-90° and 90-120° knee flexion. INTERPRETATION: Patellar contact force was significantly lower, especially on the lateral side in mobile than in fixed-bearing total knee arthroplasty, whereas no significant difference in tibial internal rotation was found between the two inserts. Mobile-bearing inserts might reduce the patellar contact force by the bearing rotation, rather than natural tibial rotation during posterior stabilized total knee arthroplasty.

  Jun. 2020, Clinical biomechanics (Bristol, Avon), 76, 105022 - 105022, English, International magazine

  Scientific journal


• Prediction of intra-articular pathology and arthroscopic outcomes for femoroacetabular impingement and labral tear based on the response to preoperative anaesthetic hip joint injections.

  Nobuaki Chinzei, Shingo Hashimoto, Shinya Hayashi, Koji Takayama, Tomoyuki Matsumoto, Ryosuke Kuroda

  OBJECTIVE: This study investigated whether the preoperative response to intra-articular injections is associated with intra-articular pathological findings and arthroscopy outcomes. METHODS: This study included 49 patients who underwent arthroscopic hip surgery for femoroacetabular impingement and labral tear after receiving preoperative hip joint injections. The response to anaesthetic injections was categorized as poor (0-50%) or good (51-100%). With respect to anatomical indices, we evaluated the lateral centre-edge angle (LCEA), acetabular roof obliquity (ARO), vertical-centre-anterior angle (VCA), and the alpha angle (on a lateral view). We evaluated the association between these indices (including the types of hip labral tears and cartilage damage) and the effectiveness of intra-articular injections. RESULTS: The study included 22 men and 27 women, and the mean age of patients was 36.4 years. No statistically significant association was observed between the response to preoperative anaesthetic hip joint injections and patient demographics (age, sex) and anatomical indices (LCEA, ARO, VCA, and alpha angle) (p > 0.05). All patients showed labral damage; however, labral tear classification or cartilage damage was not significantly associated with the effectiveness of joint injections. At the 1-year post-operative follow-up, patients with a good response to anaesthetic hip joint injections showed a significantly better outcome than patients with a poor response to these injections (p < 0.01). CONCLUSION: The response to preoperative anaesthetic hip joint injections may indicate the presence of intra-articular pathology. Furthermore, this association may have predictive value in determining post-operative outcomes following hip arthroscopy.

  May 2020, European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 30(4) (4), 737 - 742, English, International magazine

  Scientific journal


• Deletion of p21 expression accelerates cartilage tissue repair via chondrocyte proliferation.

  Kazuyuki Ibaraki, Shinya Hayashi, Noriyuki Kanzaki, Shingo Hashimoto, Shinsuke Kihara, Masahiko Haneda, Kazuhiro Takeuchi, Takahiro Niikura, Ryosuke Kuroda

  Articular cartilage tissue has a poor healing potential, and when subjected to traumatic damage this tissue undergoes cartilage degeneration and osteoarthritis. The association between the regulation of cell cycle checkpoints and tissue regeneration has been previously investigated, and p21 was initially identified as a potent inhibitor of cell cycle progression. However, the effects of p21 defects on damaged tissue remain controversial. Therefore, the aim of the present study was to evaluate the effects of p21 deficiency on cartilage repair. A mouse model of articular cartilage repair was generated by inducing a patellar groove scratch in 8‑week‑old p21‑knockout (KO) mice and C57Bl/6 wild‑type (WT) mice. Mice were sacrificed at 4 and 8 weeks post‑surgery. The present study also investigated the effect of p21 deficiency on cartilage differentiation in ATDC5 cells in vitro. Safranin O staining results indicated that cartilage repair initially occurred in p21 KO mice. In addition, immunohistochemical analysis demonstrated that p21 KO upregulated proliferating cell nuclear antigen and increased cell proliferation. However, type II collagen and Sox9 expression levels remained unchanged in p21 KO and WT mice. Moreover, it was identified that p21 downregulation did not affect Sox9 and type II collagen expression levels in vitro. Furthermore, p21 deficiency promoted healing of articular cartilage damage, which was associated with cell proliferation in vivo, and increased chondrocyte proliferation but not differentiation in vitro. Therefore, the present results suggested that p21 does not affect Sox9 or type II collagen expression levels during cartilage differentiation in the repair of cartilage defects.

  May 2020, Molecular medicine reports, 21(5) (5), 2236 - 2242, English, International magazine

  Scientific journal


• Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model.

  Masanori Tsubosaka, Shinsuke Kihara, Shinya Hayashi, Junpei Nagata, Toshie Kuwahara, Masahiro Fujita, Kenichi Kikuchi, Yoshinori Takashima, Tomoyuki Kamenaga, Yuichi Kuroda, Kazuhiro Takeuchi, Koji Fukuda, Koji Takayama, Shingo Hashimoto, Tomoyuki Matsumoto, Takahiro Niikura, Yasuhiko Tabata, Ryosuke Kuroda

  Eicosapentanoic acid (EPA) is an antioxidant and omega-3 polyunsaturated fatty acid that reduces inflammatory cytokine production. Gelatin hydrogel can be used as a carrier of a physiologically active substance that release it gradually for an average of ~3 weeks. Therefore, this study aimed to clarify the effect of EPA-incorporating gelatin hydrogels on osteoarthritis (OA) progression in vivo. Ten-week-old male C57BL/6J mice were randomly divided into six groups (n = 6): Sham, destabilization of the medial meniscus (DMM), Corn: DMM + 2 µL corn oil, EPA injection alone (EPA-I): DMM + 2 µL corn oil + 125 μg/μL EPA, Gel: DMM + gelatin hydrogels, and EPA-G: DMM + 125 μg/μL EPA-incorporating gelatin hydrogels. The mice were euthanized at 8 weeks after DMM or Sham surgery, and subjected to histological evaluation. Matrix-metalloproteinases-3 (MMP-3), MMP-13, interleukin-1β (IL-1β), p-IKK α/β, CD86, and CD163 protein expression in the synovial cartilage was detected by immunohistochemical staining. F4/80 expression was also assessed using the F4/80 score of macrophage. Histological score was significantly lower in EPA-G than in EPA-I. MMP-3-, MMP-13-, IL-1β-, and p-IKK α/β-positive cell ratio was significantly lower in EPA-G than in EPA-I. However, CD86- and CD163-positive cell ratio was not significantly different between EPA-I and EPA-G. The average-sum F4/80 score of macrophage in EPA-G was significantly lower than that in EPA-I. EPA-incorporating gelatin hydrogels were shown to prevent OA progression in vivo more effectively than EPA injection alone. Our results suggested that intra-articular administration of controlled-release EPA can be a new therapeutic approach for treating OA.

  Apr. 2020, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 38(10) (10), 2157 - 2169, English, International magazine

  [Refereed]

  Scientific journal


• Recovery of activity level following total hip arthroplasty in patients less than 60 years of age.

  Kazuhiro Takeuchi, Shingo Hashimoto, Tomoyuki Matsumoto, Shinya Hayashi, Koji Takayama, Ryosuke Kuroda

  BACKGROUND: Total hip arthroplasty (THA) is a useful treatment for pain relief and functional improvement. THA indications now include younger, more active patients, with improved implant design and bearing materials. We aimed to investigate daily activity level and return to work after THA, about which limited information is available. Moreover, differences in patient background and clinical parameters including size of femoral head and surgical approach were evaluated. METHODS: A multicentre survey was carried out in patients below 60 years, undergoing THA between 2007 and 2012, at least 1 year after surgery. Primary THA patients with osteoarthritis, avascular necrosis, rheumatoid arthritis, hip dysplasia, and no history of postoperative complications were included. The questionnaire included daily activity and occupation levels before and after surgery. University of California, Los Angeles (UCLA) activity score and occupational classification index were defined, and statistical analysis was performed. RESULTS: The mean preoperative UCLA score in 204 patients was 4.55 which improved to 6.17 after surgery. Pre- as well as postoperative UCLA scores in males were significantly higher than that in females. No differences were observed in other parameters. Return to work rate in males was 94.4%; significantly higher than that in females (52.3%). Younger patients with large head THA were more likely to return to work. CONCLUSIONS: Most patients showed improved activity levels. Satisfaction levels were higher in young males with large femoral head size. Patients with a higher preoperative work level are expected to have a higher return to work rate.

  Mar. 2020, Hip international : the journal of clinical and experimental research on hip pathology and therapy, 31(5) (5), 1120700020911911 - 1120700020911911, English, International magazine

  Scientific journal


• Postoperative excessive anterior acetabular coverage is associated with decrease in range of motion after periacetabular osteotomy.

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Nao Shibanuma, Kazunari Ishida, Takahiro Niikura, Kotaro Nishida, Ryosuke Kuroda

  PURPOSE: The aim of this study was to evaluate the relationship between acetabular 3-dimensional (3D) alignment reorientation and clinical range of motion (ROM) after periacetabular osteotomy (PAO). METHODS: 50 patients (58 hips) with hip dysplasia participated in the study and underwent curved PAO. The pre- and postoperative 3D centre-edge (CE) angles and femoral anteversion were measured and compared with clinical outcomes, including postoperative ROM. RESULTS: The correlation between pre- and postoperative acetabular coverage and postoperative ROM was evaluated. Postoperative abduction and internal rotation ROM were significantly associated with postoperative lateral CE angles (abduction; p < 0.001, internal rotation; p = 0.028); flexion and internal rotation ROM was significantly associated with postoperative anterior CE angles (flexion; p < 0.001, internal rotation; p = 0.028). Femoral anteversion was negatively correlated with postoperative abduction (p = 0.017) and external rotation (p = 0.047) ROM. CONCLUSION: Postoperative anterior acetabular coverage may affect internal rotation ROM more than the lateral coverage. Therefore, the direction of acetabular reorientation should be carefully determined according to 3D alignment during PAO.

  Mar. 2020, Hip international : the journal of clinical and experimental research on hip pathology and therapy, 31(5) (5), 1120700020910370 - 1120700020910370, English, International magazine

  Scientific journal


• 特発性大腿骨頭壊死症に対するTHA・大腿骨骨切り術における経時的QOL調査

  坂井 孝司, 上杉 裕子, 安藤 渉, 関 泰輔, 林 申也, 中村 順一, 稲葉 裕, 高橋 大介, 佐々木 幹, 中島 康晴, 間島 直彦, 加畑 多文, 須藤 啓広, 神野 哲也, 名越 智, 山本 謙吾, 仲宗根 哲, 山本 卓明, 菅野 伸彦

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1089 - S1089, Japanese


• 特発性大腿骨頭壊死症に対するTHA・大腿骨骨切り術における経時的QOL調査

  坂井 孝司, 上杉 裕子, 安藤 渉, 関 泰輔, 林 申也, 中村 順一, 稲葉 裕, 高橋 大介, 佐々木 幹, 中島 康晴, 間島 直彦, 加畑 多文, 須藤 啓広, 神野 哲也, 名越 智, 山本 謙吾, 仲宗根 哲, 山本 卓明, 菅野 伸彦

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1089 - S1089, Japanese

  [Refereed]


• Surgically Treated Nonunion following Ischial Tuberosity Avulsion Fracture of a 14-Year-Old Athlete.

  Yuta Nakamatsu, Tomoaki Fukui, Keisuke Oe, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  A 14-year-old girl experienced acute left buttock pain during a sprint. At the local hospital, she was diagnosed with an avulsion fracture of the left ischial tuberosity. She was kept for observation for about 10 months; however, the buttock pain persisted, and the bone fragments did not unite. She was referred to our hospital approximately 11 months after the injury. Plain radiography revealed an increased transposition of the bone fragment, from 12 mm immediately after the injury to 23 mm. Twelve months after the injury, she underwent osteosynthesis using two cannulated cancellous screws and three suture anchors. Following postoperative rehabilitation, the power in her left hamstring recovered, and she was able to run at full speed and returned to athletics 9 months after the surgery. The operative indications for avulsion fractures of the ischial tuberosity are unclear. Careful follow-up is required as the rate of nonunion after conservative treatment tends to be high. This needs to be identified in order to provide timely treatment that allows for early return to sport. Although she had significant chronic pain and muscle weakness, the surgery successfully treated the fracture, and her muscle power recovered, leading to her return to sports.

  2020, Case reports in orthopedics, 2020, 8531648 - 8531648, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Exploratory clinical trial on the safety and bactericidal effect of 222-nm ultraviolet C irradiation in healthy humans.

  Tomoaki Fukui, Takahiro Niikura, Takahiro Oda, Yohei Kumabe, Hiroyuki Ohashi, Masahiro Sasaki, Tatsushi Igarashi, Makoto Kunisada, Nozomi Yamano, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Shinya Hayashi, Chikako Nishigori, Ryosuke Kuroda

  INTRODUCTION: Surgical site infection is one of the most severe complications of surgical treatments. However, the optimal procedure to prevent such infections remains uninvestigated. Ultraviolet radiation C (UVC) with a short wavelength has a high bactericidal effect; however, it is cytotoxic. Nonetheless, given that UVC with a wavelength of 222 nm reaches only the stratum corneum, it does not affect the skin cells. This study aimed to investigate the safety of 222-nm UVC irradiation and to examine its skin sterilization effect in healthy volunteers. METHODS: This trial was conducted on 20 healthy volunteers. The back of the subject was irradiated with 222-nm UVC at 50-500 mJ/cm2, and the induced erythema (redness of skin) was evaluated. Subsequently, the back was irradiated with a maximum amount of UVC not causing erythema, and the skin swabs before and after the irradiation were cultured. The number of colonies formed after 24 hours was measured. In addition, cyclobutene pyrimidine dimer (CPD) as an indicator of DNA damage was measured using skin tissues of the nonirradiated and irradiated regions. RESULTS: All subjects experienced no erythema at all doses. The back of the subject was irradiated at 500 mJ/cm2, and the number of bacterial colonies in the skin swab culture was significantly decreased by 222-nm UVC irradiation. The CPD amount produced in the irradiated region was slightly but significantly higher than that of the non-irradiated region. CONCLUSION: A 222-nm UVC at 500 mJ/cm2 was a safe irradiation dose and possessed bactericidal effects. In the future, 222-nm UVC irradiation is expected to contribute to the prevention of perioperative infection.

  2020, PloS one, 15(8) (8), e0235948, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Sciatic Nerve Palsy following Curved Periacetabular Osteotomy.

  Masahiro Fujita, Shinya Hayashi, Kenichi Kikuchi, Yoshinori Takashima, Tomoyuki Kamenaga, Masanori Tsubosaka, Koji Fukuda, Koji Takayama, Shingo Hashimoto, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Curved periacetabular osteotomy (CPO) is used for the treatment of dysplastic hips. Previous studies have reported satisfying outcomes and low rate of severe complications associated with this procedure; however, no case of postoperative sciatic nerve palsy has been reported. In this study, we describe a case of postoperative sciatic nerve palsy following CPO due to nerve strangulation by scar tissue without direct injury. A female patient had severe buttock pain and posterior leg numbness after she underwent left-side CPO. Postoperative magnetic resonance imaging showed that the sciatic nerve was strangulated by the surrounding soft tissue. There was no bone fragment, active infection, bone necrosis, tumor, or spine disease. Therefore, we diagnosed nerve palsy by soft tissue strangulation, and revision surgery was indicated. During revision surgery, the sciatic nerve was observed to be strangulated by the scarring soft tissue, and the nerve had no mobility. After detachment, the pain and numbness disappeared. Direct injury of the sciatic nerve should not be caused by CPO; however, there is a possibility of postoperative sciatic nerve palsy due to the scarring soft tissue. Early diagnosis and appropriate treatment are important for optimal postoperative clinical outcomes.

  2020, Case reports in orthopedics, 2020, 8569285 - 8569285, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Accelerometer-Based Portable Navigation System Is Useful for Tibial Bone Cutting in Modified Kinematically Aligned Total Knee Arthroplasty.

  Masanori Tsubosaka, Tomoyuki Kamenaga, Yuichi Kuroda, Koji Takayama, Shingo Hashimoto, Kazunati Ishida, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  Several studies have reported better clinical outcomes following kinematically aligned total knee arthroplasty (KA-TKA) than mechanically aligned TKA. Consistent reproduction of a KA-TKA is aided by accurate tibial bone resections using computer navigation systems. This study compares an accelerometer-based portable navigation system with a conventional navigation system on tibial bone resection and clinical outcomes in KA-TKA. This study included 60 knees of patients who underwent primary KA-TKA between May 2015 and September 2017. They were randomly assigned to the OrthoPilot and iASSIST groups. A tibial bone cut was performed with 3 degree varus and 7 degree posterior slope in relation to the mechanical axis in all cases. The tibial component angle (TCA) and posterior slope angle (PSA) were evaluated by postoperative radiography, and those that deviated more than 2 degree were set as outliers. The clinical outcomes were the knee range of motion (ROM) and 2011 Knee Society Score (KSS) evaluated at 1 year postoperation. The groups were compared in terms of the TCA, PSA, number of outliers, ROM, and 2011 KSS (p < 0.05). No significant difference was observed between the groups in terms of the mean TCA, PSA, number of outliers, ROM, and categories of the 2011 KSS (objective knee indicators, symptoms, satisfaction, expectations, and functional activities). Although tibial bone cuts were performed with 3 degree varus and 7 degree posterior slope, no significant difference was observed between the OrthoPilot and iASSIST groups in terms of the accuracy of cuts or postoperative clinical result. The iASSIST was found to be a simple and useful navigation system for KA-TKA.

  Dec. 2019, The journal of knee surgery, 34(8) (8), 870 - 876, English, International magazine

  Scientific journal


• Radiographic Comparison of the Mechanical Axis Including Calcaneus to the Conventional Mechanical Axis in Medial Unicompartmental Knee Arthroplasty.

  Yuichi Kuroda, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Shingo Hashimoto, Masanori Tsubosaka, Tomoyuki Kamenaga, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Since a hindfoot alignment is not included in the conventional mechanical axis (hip-ankle [HA] line), a mechanical axis including the calcaneus (hip-calcaneus [HC] line) has recently attracted attention as an alternative weight-bearing line. However, there are few reports on unicompartmental knee arthroplasty (UKA) regarding the HC line. Therefore, this study aimed to compare postoperative alignments after UKA between the HA line and the HC line. Postoperatively, HC radiographs were taken in 88 consecutive patients who underwent medial UKA. The hip-knee-ankle (HKA) and hip-knee-calcaneus (HKC) angles were compared in the same patient. Regarding tibial inclination, the conventional tibial component-ankle (TCA) angle was compared with reference to the HC line (tibial component-calcaneus [TCC] angle). The mean postoperative HKA and HKC angles were 2.8 ± 2.7 and 2.0 ± 2.5 degree, respectively. The mean postoperative TCA and TCC angles were 87.7 ± 2.1 and 88.5 ± 2.1 degree, respectively. There were significant differences between the two groups in both lower limb alignment and tibial component angle. The present study indicated that the HKC and the TCC angles significantly decreased the varus alignment by approximately 1 degree compared with the HKA and TCA angles. Neutral in the HA line corresponds to valgus in reference to the HC line, which may result in overcorrection. Surgeons should consider evaluating the HC line in place of the HA line, which may affect preoperative planning and postoperative outcome during UKA. This is a Level II, diagnostic study.

  Dec. 2019, The journal of knee surgery, 34(9) (9), 930 - 935, English, International magazine

  Scientific journal


• Ras associated with diabetes may play a role in fracture nonunion development in rats.

  Takahiro Oda, Takahiro Niikura, Tomoaki Fukui, Michio Arakura, Keisuke Oe, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Rad is the prototypic member of a subfamily of Ras-related small G-proteins and is highly expressed in the skeletal muscle of patients with type II diabetes. Our previous microarray analysis suggested that Rad may mediate fracture nonunion development. Thus, the present study used rat experimental models to investigate and compare the gene and protein expression patterns of both Rad and Rem1, another RGK subfamily member, in nonunions and standard healing fractures. METHODS: Standard healing fractures and nonunions (produced via periosteal cauterization at the fracture site) were created in the femurs of 3-month-old male Sprague-Dawley rats. At post-fracture days 7, 14, 21, and 28, the fracture callus and fibrous tissue from the standard healing fractures and nonunions, respectively, were harvested and screened (via real-time PCR) for Rad and Rem1 expression. The immunolocalization of both encoded proteins was analyzed at post-fracture days 14 and 21. At the same time points, hematoxylin and eosin staining was performed to identify the detailed tissue structures. RESULTS: Results of real-time PCR analysis showed that Rad expression increased significantly in the nonunions, compared to that in the standard healing fractures, at post-fracture days 14, 21, and 28. Conversely, immunohistochemical analysis revealed the immunolocalization of Rad to be similar to that of Rem1 in both fracture types at post-fracture days 14 and 21. CONCLUSIONS: Rad may mediate nonunion development, and thus, may be a promising therapeutic target to treat these injuries.

  Dec. 2019, BMC musculoskeletal disorders, 20(1) (1), 602 - 602, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Therapeutic potential of vascular stem cells for anterior cruciate ligament reconstruction.

  Tomoyuki Matsumoto, Koji Takayama, Shinya Hayashi, Takahiro Niikura, Takehiko Matsushita, Ryosuke Kuroda

  Dec. 2019, Annals of translational medicine, 7(Suppl 8) (Suppl 8), S286, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Effects of the duration of transcutaneous CO2 application on the facilitatory effect in rat fracture repair.

  Takahiro Oda, Takashi Iwakura, Tomoaki Fukui, Keisuke Oe, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Teruya Kawamoto, Yoshitada Sakai, Toshihiro Akisue, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Carbon dioxide therapy has been reported to be effective in treating certain cardiac diseases and skin problems. Although a previous study suggested that transcutaneous carbon dioxide application accelerated fracture repair in association with promotion of angiogenesis, blood flow, and endochondral ossification, the influence of the duration of carbon dioxide application on fracture repair is unknown. The aim of this study was to investigate the effect of the duration of transcutaneous carbon dioxide application on rat fracture repair. METHODS: A closed femoral shaft fracture was created in each rat. Animals were randomly divided into four groups: the control group; 1w-CO2 group, postoperative carbon dioxide treatment for 1 week; 2w-CO2 group, postoperative carbon dioxide treatment for 2 weeks; 3w-CO2 group, postoperative carbon dioxide treatment for 3 weeks. Transcutaneous carbon dioxide application was performed five times a week in the carbon dioxide groups. Sham treatment, where the carbon dioxide was replaced with air, was performed for the control group. Radiographic, histological, and biomechanical assessments were performed at 3 weeks after fracture. RESULTS: The fracture union rate was significantly higher in the 3w-CO2 group than in the control group (p < 0.05). Histological assessment revealed promotion of endochondral ossification in the 3w-CO2 group than in the control group. In the biomechanical assessment, all evaluation items related to bone strength were significantly higher in the 3w-CO2 group than in the control group (p < 0.05). CONCLUSIONS: The present study, conducted using an animal model, demonstrated that continuous carbon dioxide application throughout the process of fracture repair was effective in enhancing fracture healing.

  Oct. 2019, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(5) (5), 886 - 891, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Evaluation of the accuracy of acetabular cup orientation using the accelerometer-based portable navigation system.

  Hayashi S, Hashimoto S, Takayama K, Matsumoto T, Kamenaga T, Fujishiro T, Hiranaka T, Niikura T, Kuroda R

  BACKGROUND: Accurate orientation of acetabular and femoral components is important during total hip arthroplasty (THA). In recent years, several navigation systems have been developed. However, these navigation systems for THA are unpopular worldwide because of their high cost. We assessed the orientation accuracy of cups inserted using a disposable accelerometer-based portable navigation system for THAs. METHODS: This was a prospective cohort study. We analyzed 63 hips with navigation prospectively and 30 hips without navigation retrospectively as historical control. The patients underwent THA via the mini anterolateral approach in the supine position using an accelerometer-based portable navigation system. We compared the preoperative target angles, intraoperative cup angles using navigation records, postoperative angles using postoperative CT data, measurement errors of cup angles, and clinical parameters such as sex, treated side, age at surgery, and body mass index (BMI). RESULTS: The average absolute error (postoperative CT-navigation record) was 2.7 ± 2.1° (inclination) and 2.7 ± 1.8° (anteversion), and the absolute error (postoperative CT-preoperative target angle) was 2.6 ± 1.9° (inclination) and 2.7 ± 2.2° (anteversion). The absolute error between postoperative CT and target angle with navigation was significantly lower than the error without navigation (inclination; p = 0.025, anteversion; p = 0.005). Cup malalignment (absolute difference of inclination or anteversion between postoperative CT and preoperative target angle of over 5°) was significantly associated with BMI value (OR: 1.3, 95% CI: 1.1-1.7). The absolute measurement error of cup inclination and anteversion was significantly correlated with patients' BMI (inclination error: correlation coefficient = 0.53, p < 0.001, anteversion error: correlation coefficient = 0.58, p < 0.001). CONCLUSIONS: The clinical accuracy of accelerometer-based portable navigation is precise for the orientation of cup placement, although accurate cup placement was affected by high BMI. This is the first study to report the accuracy of accelerometer-based portable navigation for THA in the supine position.

  Oct. 2019, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(4) (4), 612 - 617, English, Domestic magazine

  [Refereed]

  Scientific journal


• 人工関節全置換術後に発症した急性膝窩動脈閉塞症を保存的に治療し得た2例

  前田 琢磨, 松本 知之, 高山 考治, 林 申也, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(5) (5), 803 - 804, Japanese


• Charcot-Marie-Tooth病に伴う神経病性膝関節症に対し拘束型人工膝関節全置換術を施行した2例

  江原 豊, 松本 知之, 高山 孝治, 林 申也, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(5) (5), 805 - 806, Japanese


• Insufficiency and deficiency of vitamin D in elderly patients with fragility fractures of the hip in the Japanese population.

  Niikura T, Oe K, Sakai Y, Iwakura T, Fukui T, Nishimoto H, Hayashi S, Matsumoto T, Matsushita T, Maruo A, Yagata Y, Kishimoto K, Sakurai A, Kuroda R

  Sep. 2019, Journal of orthopaedic surgery (Hong Kong), 27(3) (3), 2309499019877517, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Medial knee stability at flexion increases tibial internal rotation and knee flexion angle after posterior-stabilized total knee arthroplasty.

  Kamenaga T, Takayama K, Ishida K, Muratsu H, Hayashi S, Hashimoto S, Kuroda Y, Tsubosaka M, Takashima Y, Matsushita T, Niikura T, Kuroda R, Matsumoto T

  BACKGROUND: Soft-tissue balance is an important element for the success of total knee arthroplasty; however, the influence of intraoperative soft-tissue balance on knee kinematics in posterior-stabilized-total knee arthroplasty remains unknown. We investigated whether intraoperative soft-tissue balance could influence knee kinematics and flexion angle after posterior-stabilized-total knee arthroplasty. METHODS: This study included 30 patients with knee osteoarthritis and varus alignment who underwent posterior-stabilized total knee arthroplasty; intraoperative soft-tissue balance parameters, such as varus ligament balance and joint component gap, were assessed by an offset-type tensor at knee flexion angles of 0°, 10°, 30°, 60°, 90°, 120°, and 135°. Medial and lateral compartment gaps were calculated. The amount of tibial internal rotation was determined between 60° and 135° flexion by the navigation system. Simple linear regression analysis was used to analyze the effects of intraoperative soft-tissue balance on tibial internal rotation. Linear regression analysis was used to assess correlation between tibial internal rotation and postoperative knee flexion angle. FINDINGS: Medial compartment gaps at 60° (r = -0.57, P < 0.05) and 90° (r = -0.60, P < 0.05) of flexion were significantly negatively correlated with tibial internal rotation. Moreover, tibial internal rotation showed a significant correlation with the 2-year postoperative knee flexion angle (r = 0.50, P < 0.05) and improvement in knee flexion angle (r = 0.61, P < 0.05). INTERPRETATION: Thus, smaller medial compartment gaps at 60° and 90° of flexion play an important role in achieving medial pivot motion with tibial internal rotation; moreover, tibial internal rotation provides a better flexion angle after posterior-stabilized total knee arthroplasty.

  Aug. 2019, Clinical biomechanics (Bristol, Avon), 68, 16 - 22, English, International magazine

  [Refereed]

  Scientific journal


• Improved implant alignment accuracy with an accelerometer-based portable navigation system in medial unicompartmental knee arthroplasty.

  Suda Y, Takayama K, Ishida K, Hayashi S, Hashimoto S, Niikura T, Matsushita T, Kuroda R, Matsumoto T

  PURPOSE: This study aimed to examine the accuracy of tibial implant alignment using an accelerometer-based portable navigation system in unicompartmental knee arthroplasty (UKA). METHODS: This retrospective matched case-control study reviewed 51 UKAs performed using an accelerometer-based portable navigation system, matched with 51 UKAs performed using conventional extramedullary rods. Coronal alignment and posterior slope of the tibial implant were measured on postoperative radiographs, and differences from preoperative planning were examined. Outliers and accuracy of tibial implant alignment were compared between the portable navigation and conventional groups using Fisher's exact test and Mann-Whitney U test, respectively. RESULTS: In the portable navigation group, 100% of the implants were aligned within 3.0° of both target coronal and sagittal implant alignment. In the conventional group, 76.5% and 88.2% of the implants were within 3.0° of both target coronal and sagittal implant alignment. Statistical analysis revealed that outliers of coronal and sagittal alignment were significantly less in the portable navigation group than in the conventional group (P < 0.05). In addition, the absolute value difference between postoperative measurement and preoperative planning of both coronal and sagittal alignment was significantly smaller in the portable navigation group than in the conventional group (P < 0.05). CONCLUSION: The portable navigation system improved the accuracy of tibial implant alignment in UKA. We found that 100% of the implants were aligned within 3.0° of both target coronal and sagittal implant alignment. The portable navigation system decreased the outliers of tibial coronal and sagittal alignment. LEVEL OF EVIDENCE: Retrospective case-control study, Level III.

  Aug. 2019, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 28(9) (9), 2917 - 2923, English, International magazine

  [Refereed]

  Scientific journal


• Expression profiling of genes in rheumatoid fibroblast-like synoviocytes regulated by tumor necrosis factor-like ligand 1A using cDNA microarray analysis.

  Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Ryosuke Kuroda

  Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation in synovial tissues. Hyperplasia of synovial tissue leads to the formation of pannus, which invades joint cartilage and bone resulting in joint destruction. Tumor necrosis factor-like ligand 1A (TL1A), a member of the tumor necrosis factor superfamily (TNFSF15), contributes to the pathogenesis of autoimmune diseases, including RA. In the present study, a cDNA microarray was used to search for genes whose expression in rheumatoid fibroblast-like synoviocytes (RA-FLS) were regulated by TL1A. Four individual lines of primary cultured RA-FLS were incubated either with recombinant human TL1A protein or phosphate-buffered saline, as an unstimulated control, for 12 h. Gene expression was then detected through the microarray assay. The results revealed the expression profiles of genes in RA-FLS regulated by TL1A. The present study also demonstrated the functions of those genes whose expression in RA-FLS was regulated by TL1A. Among the genes in this profile, the present study focused on the following genes: Spectrin repeat-containing nuclear envelope 1, Fc receptor-like 2, PYD (pyrin domain)-containing 1, cell division cycle 45 homolog, signal transducer and activator of transcription 5B, and interferon regulatory factor 4. These genes may affect the pathogenesis of RA, including proliferation, regulation of B cells and T cells, inflammation, and cytokine processing. The present study revealed for the first time, to the best of our knowledge, the expression profile of genes in RA-FLS regulated by TL1A. The data indicate that TL1A may regulate the gene expression of various key molecules in RA-FLS, thus affecting the pathogenesis of RA. Further investigations of the genes detected in the current profiles may provide a deeper understanding of the pathogenesis and a novel target for the treatment of RA.

  Jul. 2019, Biomedical reports, 1(1) (1), 1 - 5, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Intraoperative posterior movement of the tibia at 90° of flexion predicts worse postoperative flexion angles in cruciate-substituting total knee arthroplasty.

  Inokuchi T, Ishida K, Takayama K, Shibanuma N, Hayashi S, Kurosaka M, Kuroda R, Matsumoto T

  PURPOSE: To investigate the correlation between intraoperative tibiofemoral anteroposterior changes at 90° of flexion and postoperative maximum flexion angles in navigated cruciate-substituting TKA. The hypothesis of this study was that intraoperative tibiofemoral anteroposterior changes at 90° of flexion indirectly reflect posterior cruciate ligament (PCL) function and associate with postoperative maximum flexion angles. METHODS: Fifty-five consecutive patients with varus osteoarthritis treated with primary TKA were retrospectively analysed. All patients received the same type of implant, placed with an image-free navigation system. The PCL was retained, and cruciate-substituting inserts were used in all cases. The mean follow-up was 44 ± 8 months. The preoperative and postoperative kinematics were measured intraoperatively with a navigation system, and the preoperative and postoperative tibiofemoral anteroposterior positions at 90° of flexion were determined. The correlation between intraoperative anteroposterior position changes and postoperative maximum flexion angles was investigated. The correlation between the change of anteroposterior position and tibiofemoral rotational angles was also assessed. RESULTS: The intraoperative anteroposterior position change was -1.7 ± 3.4 mm (a positive value indicates tibial posterior shift). Flexion angle improvement was negatively correlated with intraoperative change of tibiofemoral anteroposterior position (R2 = 0.17, p < 0.005). Postoperative maximum flexion angles were also negatively correlated with intraoperative change of tibiofemoral anteroposterior position (R2 = 0.09, p < 0.05). The postoperative amount of tibial internal rotation was positively correlated with the preoperative amount (R2 = 0.60, p < 0.0001); however, the intraoperative anteroposterior position change was not correlated with the postoperative amount of tibial internal rotation (n.s.). CONCLUSION: A navigation system may be able to indirectly evaluate PCL function and predict the postoperative flexion angles in cruciate-substituting TKA. Intraoperative posterior movement of the tibia at 90° of flexion predicts worse postoperative flexion angles in cruciate-substituting TKA. LEVEL OF EVIDENCE: Level 3, retrospective comparative study.

  Jul. 2019, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 28(9) (9), 2816 - 2822, English, International magazine

  [Refereed]

  Scientific journal


• Intraoperative pelvic movement is associated with the body mass index in patients undergoing total hip arthroplasty in the supine position.

  Kamenaga T, Hayashi S, Hashimoto S, Takayama K, Fujishiro T, Hiranaka T, Kuroda R, Matsumoto T

  BACKGROUNDS: There are very few reports on pelvic movement during total hip arthroplasty (THA) in the supine position. We investigated intraoperative pelvic motion in the sagittal and axial planes to determine if preoperative clinical factors, including body mass index (BMI) affect intraoperative pelvic motion. METHODS: Fifty-three patients with osteoarthritis undergoing THA in the supine position were included. Clinical factors, such as age, BMI, and pelvic tilt were assessed preoperatively. Intraoperative pelvic motion in the axial and sagittal planes was assessed using a portable navigation system. We assessed the change in pelvic tilt from registration to cup implantation as the pelvic tilt change; positive values indicated anterior pelvic tilt. We measured the values and absolute values of changes in axial rotation from registration to cup implantation to determine the axial rotation angle. The effects of patient factors on pelvic motion (pelvic tilt change and axial rotation angle) were analyzed using a Spearman's correlation analysis. RESULTS: Preoperative pelvic tilt was negatively correlated with pelvic tilt change (r = -0.57, p < 0.05) and the absolute axial rotation angle (r = -0.57, p < 0.05). BMI and absolute axial rotation angle were negatively correlated (r = -0.54, p < 0.05). Age was not correlated with change in the pelvic tilt and the axial rotation angle. CONCLUSIONS: Preoperative pelvic tilt and BMI are important factors to determine intraoperative pelvic motion in patients who undergo THA in the supine position. This can help surgeons to preoperatively identify patients with a higher risk of intraoperative pelvic motion.

  Jun. 2019, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(3) (3), 446 - 451, English, Domestic magazine

  [Refereed]

  Scientific journal


• Intraoperative Soft Tissue Balance/Kinematics and Clinical Evaluation of Modified Kinematically versus Mechanically Aligned Total Knee Arthroplasty.

  Matsumoto T, Takayama K, Ishida K, Kuroda Y, Tsubosaka M, Muratsu H, Hayashi S, Hashimoto S, Matsushita T, Niikura T, Kuroda R

  Recently, kinematically aligned total knee arthroplasty has been found to achieve better clinical outcomes than mechanically aligned TKA. Despite the good clinical outcomes that are reported at short- to mid-term follow-up, intraoperative variables that are associated with a better outcome have not been measured. Therefore, this study was conducted to compare intraoperative kinematics/soft tissue balance and the clinical outcomes of patients who underwent modified kinematically (restricted tibial cut) or mechanically aligned total knee arthroplasty. Sixty cruciate-retaining total knee arthroplasties (30 modified kinematically [3-degree varus and 7-degree posterior slope in tibial cut] and 30 mechanically aligned) were performed in patients with varus-type osteoarthritis using a navigation system. Intraoperative kinematics assessed by the navigation system and soft tissue balance assessed by an offset-type tensor were compared between the groups. One year postoperatively, the range of motion and 2011 Knee Society scores were compared between the groups. Kinematic assessment exhibited that tibial internal rotation during flexion was significantly maintained in the kinematic compared with the mechanical group (p < 0.05). Varus/valgus ligament balance at 90 and 120 degrees of flexion significantly maintained lateral laxity in the kinematic compared with the mechanical group (p < 0.05). Improvement of flexion angles, functional activity scores, and patient satisfaction were significantly better in the kinematic than in the mechanical group (p < 0.05). Modified kinematically aligned cruciate-retaining total knee arthroplasty maintained more tibial internal rotation and lateral laxity during flexion than mechanically aligned total knee arthroplasty; thus, the former may result in better clinical outcomes.

  May 2019, The journal of knee surgery, 33(8) (8), 777 - 784, English, International magazine

  [Refereed]

  Scientific journal


• Accuracy of cup orientation and learning curve of the accelerometer-based portable navigation system for total hip arthroplasty in the supine position.

  Kamenaga T, Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Fujishiro T, Hiranaka T, Niikura T, Kuroda R

  May 2019, Journal of orthopaedic surgery (Hong Kong), 27(2) (2), 2309499019848871

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Denosumab Treatment Improved Health-Related Quality of Life in Osteoporosis: A Prospective Cohort Study.

  HAYASHI S, Fukuda K, Maeda T, Chinzei N, Kihara S, Miura Y, Sakai Y, Hashimoto S, Matsumoto T, Takayama K, Niikura T, Kuroda R

  May 2019, JBMR Plus., 3(7) (7), 10191 - 10191, English

  [Refereed]

  Scientific journal


• 関節リウマチの病因・病態-1 関節リウマチの発症年齢に関与する遺伝子の探索

  橋本 麿和, 舟橋 恵子, 奥田 康介, 福田 康治, 林 申也, 佐川 昭, 松野 博明, 泉原 智麿, 生野 英祐, 片山 耕, 土田 豊実, 岩橋 充啓, 都留 智巳, 織部 元廣, 松原 司

  (一社)日本リウマチ学会, Mar. 2019, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 427 - 427, Japanese

  [Refereed]


• 関節リウマチの治療評価と予測-3 ゲノムワイドSNP解析によるトシリズマブの治療有効性と二次無効の予測

  亀長 智幸, 林 申也, 福田 康治, 高島 良典, 黒田 良祐, 橋本 麿和, 舟橋 恵子, 松原 司

  (一社)日本リウマチ学会, Mar. 2019, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 517 - 517, Japanese

  [Refereed]


• FasLはリウマチ滑膜線維芽細胞における様々な遺伝子の発現を制御する

  福田 康治, 三浦 靖史, 前田 俊恒, 林 申也, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2019, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 603 - 603, Japanese

  [Refereed]


• TNF阻害薬による関節リウマチ滑膜組織の組織学的変化の検討

  高島 良典, 福田 康治, 林 申也, 亀長 智幸, 黒田 良祐, 橋本 麿和, 舟橋 恵子, 松原 司

  (一社)日本リウマチ学会, Mar. 2019, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 605 - 605, Japanese

  [Refereed]


• RA患者における関節破壊の特徴によるトシリズマブ有効性の検討

  林 申也, 松原 司, 福田 康治, 舟橋 恵子, 橋本 麿和, 亀長 智幸, 高島 良典, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2019, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 618 - 618, Japanese

  [Refereed]


• 多施設コホートを用いたイグラチモドの治療継続率

  福田 康治, 松原 司, 舟橋 恵子, 橋本 麿和, 林 申也, 亀長 智幸, 高島 良典, 酒井 良忠, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2019, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 682 - 682, Japanese

  [Refereed]


• 親子間の遺伝的差異を利用した関節リウマチ感受性遺伝子の探索

  橋本 麿和, 舟橋 恵子, 奥田 康介, 福田 康治, 林 申也, 松原 司

  (一社)日本リウマチ学会, Mar. 2019, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 742 - 742, Japanese

  [Refereed]


• 関節リウマチ診療におけるトータルマネージメントの意義と重要性 関節リウマチ患者のトータルマネージメントの将来 リハビリテーション科のリウマチセンターへの参画

  酒井 良忠, 福田 康治, 西本 華子, 林 申也, 三浦 靖史, 森信 暁雄, 黒川 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S407 - S407, Japanese

  [Refereed]


• A Periprosthetic Femoral Fracture with Characteristics of Atypical Femoral Fracture.

  Shuya Tanaka, Tomoaki Fukui, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Shinya Hayashi, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Although the definition of atypical femoral fracture (AFF) excludes periprosthetic femoral fracture (PFF), the number of reports about PFF with characteristics of AFF is increasing. We present the case of such a fracture in this report. An 87-year-old woman who underwent bipolar hip arthroplasty for a femoral neck fracture 38 months prior reported left thigh pain with no history of trauma. Radiographs showed a simple transverse fracture at the level of the stem distal end with features of AFF: periosteal thickening of the lateral cortex, a medial spike, and a noncomminuted fracture. She presented other features resembling AFF: history of bisphosphonate use, prodromal symptoms, no associated trauma, and lateral bowing of the contralateral femur. The fracture showed nonunion after the initial osteosynthesis, and a revision surgery of the arthroplasty and osteosynthesis was performed. Nine months after the surgery, bony union was achieved and she regained the ability to walk. It is supposed that the fracture was influenced by a stress force related to implants and lateral bowing concentrating on the fracture site as a mechanical factor in addition to bisphosphonates as a biological factor. It would be important to recognize that AFF could occur at the peri-implant location, and early detection and treatment are essential.

  2019, Case reports in orthopedics, 2019, 1275369 - 1275369, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Recurrent Hematomas following a Revision Total Hip Arthroplasty in Acquired Coagulation Factor XIII Deficiency.

  Takashima Y, Hashimoto S, Kamenaga T, Tsubosaka M, Kuroda Y, Takeuchi K, Takayama K, Hayashi S, Kuroda R, Matsumoto T

  Coagulation factor XIII (FXIII) is the final enzyme in the coagulation cascade and plays an important role in catalyzing the intermolecular cross-linking of fibrin polymers. FXIII deficiency is a rare disorder that presents with recurrent soft tissue bleeding. In this case report, we describe a patient with recurrent hematomas, following a revision total hip arthroplasty (THA). A 50-year-old female patient with no past history of bleeding and with a normal perioperative coagulation profile presented with recurrent hip joint hematomas. Her plasma FXIII activity showed a slight decrease (69%). Therefore, the patient was diagnosed with an acquired deficiency and was administered FXIII to correct it. The bleeding did not recur once the FXIII activity had returned to a normal level (76%). At 2 months after the second evacuation procedure, the patient was discharged from the hospital in an ambulatory state. There has been no recurrence of a hematoma since. We managed a rare case of acquired FXIII deficiency, which highlighted that a patient can present with an acquired bleeding disorder despite having a normal coagulation profile. An acquired FXIII deficiency should be suspected in patients with inexplicable, sudden-onset bleeding, as early diagnosis and treatment are important to prevent life-threatening complications.

  2019, Case reports in orthopedics, 2019, 4038963 - 4038963, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Humeral Shaft Non-union in a Patient with Osteogenesis Imperfecta Treated with Mandible Locking Plate Fixation: A Case Report.

  Sano S, Oe K, Fukui T, Hayashi S, Kuroda R, Niikura T

  Introduction: Osteogenesis imperfecta (OI) is a heritable disorder of connective tissue. Due to poor bone quality, patients with OI develop bone fracture and subsequent non-union at high rates. We report the rare case of humeral shaft non-union successfully treated by a locking plate used formandibular bone in a patient with OI. Case Report: A 26-year-old man with Type III OI and a history of corrective osteotomy with Kirschner wire fixation of his right humerus at the age of 8 years developed gradually increasing pain in his humerus. He sustained humeral shaft non-union due to a broken Kirschner wire used in the previous operation and was referred to our hospital. He underwent internal fixation using an elastic nail with an iliac bone graft. However, 2 years after the operation, bony union was not achieved due to elastic nail breakage, and he complained of pain and activity limitation. He underwent re-operation for the humeral non-union using a locking plate to achieve rigid fixation. Because his humeral shaft was extremely narrow with severe deformity, we used a locking plate for the mandibular bone, which was contoured to fit the medial side of the humeral shaft. Bony union was achieved, the pain was relieved, and the patient returned to his pre-injury activity with no symptoms.4years after the operation, a new fracture line was found in radiographs of the distal part of the non-union. Bony union was achieved by conservative treatment. At present, the function has recovered. Conclusion: Humeral non-union in this patient with OI was successfully treated by a mandible locking plate. Although the optimal fixation device for fractures or non-unions in patients with OI has not yet been established, this plate could be a good treatment option for narrow and severely deformed bone.

  2019, Journal of orthopaedic case reports, 9(3) (3), 19 - 21, English, International magazine

  [Refereed]


• 関節リウマチ患者に対するTNF阻害薬の10年を超える治療継続率の比較

  黒田 良祐, 福田 康治, 林 申也, 舟橋 恵子, 松原 司, 橋本 麿和, 奥田 康介, 堤 聡, 冨田 大介, 伊丹 哲, 酒井 良忠, 三浦 靖史

  (一社)日本臨床リウマチ学会, Dec. 2018, 臨床リウマチ, 30(4) (4), 269 - 275, Japanese

  [Refereed]


• Influence of limb alignment and prosthetic orientation on patient-reported clinical outcomes in total knee arthroplasty

  Kuroda Y, Takayama Kouji, Ishida K, Hayashi Shinya, Hashimoto Shingo, Nishida K, Matsushita T, Niikura Takahiro, Kuroda Ryosuke, Matsumoto Tomoyuki

  BACKGROUND: The relationship between postoperative limb alignment and clinical outcomes in primary total knee arthroplasty (TKA) is well reported, but the instruments used to evaluate clinical outcomes of TKA are mainly scoring systems from the physician's viewpoint, not patient-reported outcomes. The purpose of this study was to investigate retrospectively the relationship between postoperative limb alignment and patient-reported clinical outcomes using the 2011 Knee Society Knee Scoring System (2011 KSS). METHODS: The present study included 155 knees of patients (median age, 74 years) who underwent primary TKA for varus osteoarthritis, with a mean follow-up period of 46 months. The subjects were divided into three groups based on postoperative limb alignment and femoral and tibial component positioning angle (varus, neutral, and valgus). The 2011 KSS scores were compared among the groups. RESULTS: For limb alignment, the postoperative objective knee indicator score was significantly lower in the valgus group than in the varus and neutral groups, whereas no significant differences were observed in any subjective categories of the 2011 KSS. However, for the femoral component angle, functional activity scores were significantly lower in the valgus group than in the varus and neutral groups. CONCLUSIONS: The subjective patient-reported score was not affected by the postoperative limb alignment. However, the valgus femoral component angle resulted in lower subjective functional scores. For clinical relevance, postoperative valgus positioning of femoral component should be avoided from patient-reported functional aspects during TKA.

  Dec. 2018, J Orthop Sci, 24(4) (4), 668 - 673, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Cyclin-Dependent Kinase Inhibitor-1-Deficient Mice Are Susceptible to Osteoarthritis Associated With Enhanced Inflammation

  KiharaS, Hayashi Shinya, Hashimoto Shingo, Kanzaki Noriyuki, Takayama Kouji, Matsumoto Tomoyuki, ChinzeiN, IwasaK, HanedaM, TakeuchiK, Nishida Kotaro, Kuroda Ryosuke

  Dec. 2018, J Bone Miner Res, 33(12) (12), 2242 - 2242, English, International magazine

  [Refereed]

  Scientific journal


• Medial joint line elevation of the tibia measured during surgery has a significant correlation with the limb alignment changes following medial unicompartmental knee arthroplasty

  Kuroda Y, Takayama Kouji, Ishida K, Hayashi Shinya, Hashimoto Shingo, Tsubosaka M, Matsushita Takehiko, Niikura Takahiro, Nishida Kotaro, Kuroda Ryosuke, Matsumoto Tomoyuki

  PURPOSE: This study aimed to determine the correlation between the change in joint line height calculated from the resected bone and insert thickness during surgery and the change in limb alignment following unicompartmental knee arthroplasty (UKA). It was hypothesized that joint line elevation is correlated with the change in limb alignment. METHODS: A total of 74 consecutive patients diagnosed with either isolated medial compartmental osteoarthritis (38 patients) or spontaneous osteonecrosis of the knee (36 patients) were included. The thickness of the proximal tibial and distal femoral bony cuts was measured during surgery; using these values, the medial joint line elevation of the tibia (MJLET) and medial joint line reduction of the femur (MJLRF) were defined. The correlation between the amount of change in the hip-knee-ankle (HKA) angle before and after surgery (δHKA) and the thickness of the tibial insert (TI), MJLET, or MJLRF were evaluated. RESULTS: The mean values of δHKA, TI, MJLET, and MJLRF were 5.0° ± 2.6°, 8.5 ± 0.8, 4.4 ± 1.3, and 0.0 ± 1.1 mm, respectively. The δHKA had a significant, but weak-positive correlation with the TI (P = 0.02), and moderate-positive correlation with MJLET (P < 0.001). However, no correlation was observed between δHKA and MJLRF. CONCLUSIONS: The MJLET measured during surgery had a significant moderate-positive correlation with the change in limb alignment following medial UKA. For clinical relevance, the surgeon can predict postoperative limb alignment after UKA by considering, intraoperatively, both the insert thickness and the depth of resection at the proximal tibia thus minimizing technical error to obtain an optimal alignment after UKA. LEVEL OF EVIDENCE: Diagnostic study, level II.

  Nov. 2018, Knee Surg Sports Traumatol Arthrosc, 26(11) (11), 3468 - 3473, English, International magazine

  [Refereed]

  Scientific journal


• Computer-assisted surgery prevents complications during peri-acetabular osteotomy

  Hayashi Shinya, Hashimoto Shingo, Matsumoto Tomoyuki, Takayama Kouji, Shibanuma N, Ishida K, Nishida Kotaro, Kuroda Ryosuke

  PURPOSE: The aim of study is to evaluate the accuracy of a navigation system during curved peri-acetabular osteotomy (CPO). METHODS: Forty-seven patients (53 hips) with hip dysplasia were enrolled and underwent CPO with or without navigation during surgery. Clinical and radiographical evaluations were performed and compared between the navigation group and non-navigation group, post-operatively. RESULTS: The clinical outcomes were not significantly different between the navigation and non-navigation groups. Furthermore, post-operative reorientation of the acetabular fragment was similar between the navigation and non-navigation groups. However, the discrepancy between the pre-operative planning line and post-operative osteotomy line was significantly improved in the navigation group compared with that in the non-navigation group (p < 0.05). Further, the complication rate was significantly improved in the navigation group (p < 0.001). CONCLUSION: The accuracy of the osteotomy's position was significantly improved by using the navigation. Therefore, the use of navigation during peri-acetabular osteotomy can avoid complications.

  Nov. 2018, Int Orthop, 42(11) (11), 2555 - 2561, English, International magazine

  [Refereed]

  Scientific journal


• A prospective randomized comparative study to determine appropriate edoxaban administration period, to prevent deep vein thromboembolism in patients with total knee arthroplasty

  Ishida K, Shibanuma N, Kodato K, Toda A, Sasaki H, Takayama Kouji, Hayashi Shinya, Hashimoto Shingo, Matsushita T, Niikura Takahiro, Kurosaka M, Kuroda Ryosuke, Matsumoto Tomoyuki

  BACKGROUND: This study aimed to determine the appropriate administration duration of edoxaban 15 mg (a factor Xa inhibitor) for the prevention of deep vein thrombosis (DVT) after total knee arthroplasty (TKA). METHODS: Our study comprised 202 patients who underwent TKA (excluding bilateral TKA) at our institution between 2014 and 2015. The subjects received edoxaban 15 mg daily for 1 (n = 93) or 2 (n = 109) weeks; group assignment was random. B-mode ultrasonography was performed 7 and 14 days post-TKA for the detection of DVT. We compared the incidence of DVT between the groups and examined for side effects. RESULTS: The demographic data of the patients in the 1- and 2-week administration groups were similar at baseline. DVT incidence did not differ significantly between the groups at 1 week post-TKA. However, it was significantly lower in the 2-week administration group (n = 0) than in the 1-week administration group (n = 7; p = 0.004) at 2 weeks post-DVT. Neither group exhibited symptomatic DVT. A total of six patients withdrew during the study period because of hepatic dysfunction. CONCLUSIONS: Our results show that the administration of edoxaban 15 mg is more effective in preventing DVT after TKA when administered for 2 weeks than for 1 week.

  Nov. 2018, J Orthop Sci, 23(6) (6), 1005 - 1010, English, Domestic magazine

  [Refereed]

  Scientific journal


• Total ankle arthroplasty with total talar prosthesis for talar osteonecrosis with ankle osteoarthritis: A case report.

  Nobuaki Chinzei, Noriyuki Kanzaki, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Yuichi Hoshino, Shingo Hashimoto, Koji Takayama, Daisuke Araki, Ryosuke Kuroda

  Oct. 2018, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Intra-articular autologous uncultured adipose-derived stromal cell transplantation inhibited the progression of cartilage degeneration

  Kuroda Y, Matsumoto Tomoyuki, Hayashi Shinya, Hashimoto Shingo, Takayama Kouji, Kirizuki S, Tsubosaka M, Kamenaga T, Takashima Y, Matsushita T, Niikura Takahiro, Kuroda Ryosuke

  The role of uncultured adipose-derived stromal cells for osteoarthritis treatment remains unclear despite sporadic reports supporting their use in clinical settings. This study aimed to evaluate the therapeutic effects of autologous uncultured adipose-derived stromal cell transplantation in a rabbit osteoarthritis model. Uncultured adipose-derived stromal cells isolated from rabbits were administered via intra-articular injection into the knees after osteoarthritis onset. Animals were sacrificed at 8 and 12 weeks after osteoarthritis onset to compare the macroscopic, histological, and immunohistochemical characteristics between the uncultured adipose-derived stromal cell and control groups. Co-culture assay was also performed. The chondrocytes isolated from the model were co-cultured with adipose-derived stromal cells. The cell viability of chondrocytes and expression of chondrocyte-specific genes in the co-culture (uncultured adipose-derived stromal cell) group were compared with the mono-culture (control; chondrocytes only) group. In macroscopic and histological analyses, the uncultured adipose-derived stromal cell group showed less damage to the cartilage surface than the control group at 8 and 12 weeks after osteoarthritis onset. In immunohistochemical and co-culture assay, the uncultured adipose-derived stromal cell group showed higher expression of collagen type II and SRY box-9 and lower expression of matrix metalloproteinase-13 than the control group. The cell viability of chondrocytes in the uncultured adipose-derived stromal cell group was higher than that in the control group. Intra-articular autologous uncultured adipose-derived stromal cell transplantation inhibited the progression of cartilage degeneration in a rabbit osteoarthritis model by regulating chondrocyte viability and secreting chondrocyte-protecting cytokines or growth factors, which promote anabolic factors and inhibit catabolic factors. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1376-1386, 2019.

  Oct. 2018, J Orthop Res, 37(6) (6), 1376 - 1386, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 関節リウマチの生物製剤治療におけるSNPアルゴリズムの有用性

  亀長 智幸, 福田 康治, 林 申也, 酒井 良忠, 松原 司, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 134 - 134, Japanese

  [Refereed]


• Comparison of Coronal Prosthetic Alignment After Total Knee Arthroplasty Using 3 Computer-Assisted Navigation Systems.

  Sasaki H, Ishida K, Shibanuma N, Takayama K, Hayashi S, Hashimoto S, Niikura T, Kurosaka M, Kuroda R, Matsumoto T

  Recent advances in surgical tools such as navigation systems have contributed to accurate implantation in total knee arthroplasty. Although several navigation systems have been developed, reports regarding which navigation system has better accuracy are few. Therefore, this study aimed to compare the accuracy of postoperative coronal alignment among 3 navigation systems. A total of 90 knee prostheses were implanted for 90 patients with osteoarthritis. Thirty patients were enrolled in each of the following 3 navigation groups: Stryker Navigation System II (computed tomography-free navigation; Stryker, Mahwah, New Jersey); OrthoPilot version 4.2 navigation system (computed tomography-free navigation; B. Braun Aesculap, Tuttlingen, Germany); and VectorVision navigation system (computed tomography-based navigation system; BrainLAB, Munich, Germany). Thirty consecutive total knee arthroplasties performed via the conventional method without navigation were selected as a control group for comparison with the navigation groups. Postoperative coronal mechanical axis and femoral and tibial coronal component angles were compared among the groups using long-leg standing radiographs for the rate of outliers beyond 3°. No differences were observed in the mean femoral and tibial component angles among the navigation and conventional groups. However, the proportion of outliers beyond 3° was higher in the conventional group than in the 3 navigation groups. No significant differences in the outlying values were found among the 3 navigation groups. These 3 navigation systems achieved equally accurate coronal mechanical alignment with fewer outliers. The navigation systems exhibited more precise implantation than the conventional method. [Orthopedics. 2018; 41(5):e621-e628.].

  Sep. 2018, Orthopedics, 41(5) (5), e621 - e628, English, International magazine

  [Refereed]

  Scientific journal


• Downregulation of aquaporin 9 decreases catabolic factor expression through nuclear factor-κB signaling in chondrocytes

  Takeuchi K, Hayashi Shinya, Matumoto T, Hashimoto Shingo, Takayama Kouji, Chinzei N, Kihara S, Haneda M, Kirizuki S, Kuroda Y, Tsubosaka M, Nishida Kotaro, Kuroda Ryosuke

  Sep. 2018, Int J Mol Med, 42(3) (3), 1548 - 1558, English

  [Refereed]

  Scientific journal


• 関節リウマチ滑膜細胞におけるdecoy receptor 3によるcadherin 2発現誘導の検討

  福田 康治, 三浦 靖史, 林 申也, 前田 俊恒, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1985 - S1985, Japanese

  [Refereed]


• 術前評価から考える股関節唇縫合術の適応と手術手技

  橋本慎吾, Hayashi Shinya

  Aug. 2018, Hip Joint, 44(1号) (1号), 13 - 17, Japanese

  [Refereed]

  Scientific journal


• Quality of life of patients with osteonecrosis of the femoral head: a multicentre study.

  Yuko Uesugi, Takashi Sakai, Taisuke Seki, Shinya Hayashi, Junichi Nakamura, Yutaka Inaba, Daisuke Takahashi, Kan Sasaki, Goro Motomura, Naohiko Mashima, Tamon Kabata, Akihiro Sudo, Tetsuya Jinno, Wataru Ando, Satoshi Nagoya, Kengo Yamamoto, Satoshi Nakasone, Hiroshi Ito, Takuaki Yamamoto, Nobuhiko Sugano

  PURPOSE: Quality-of-life (QOL) assessments in patients with osteonecrosis of the femoral head (ONFH) have rarely been reported. This multicentre study aimed to elucidate the relationship between disease severity, including necrotic lesion type and radiological staging, and QOL, as well as between patients' characteristics and QOL. METHODS: Two hundred seventy-four patients with ONFH (108 females, 166 males; median age, 46 years) were asked to complete self-assessment QOL questionnaires including the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire, Oxford Hip Score, and SF-12v2. RESULTS: Patients with large necrotic lesion type or collapsed ONFH had low QOL scores. Among patients with non-collapsed lesions, patients with alcohol-associated ONFH had lower QOL scores than those with steroid-associated ONFH, those with bilateral ONFH had lower mental scores, and male patients had worse social condition scores. Among patients with collapsed lesions, middle-aged patients exhibited lower mental QOL, and a strong correlation was observed between social activity and mental health. CONCLUSION: Collapsed ONFH was associated with low QOL scores. Among patients with non-collapsed lesions, alcohol-associated ONFH, bilateral disease, and male sex were linked to low QOL scores.

  Jul. 2018, International orthopaedics, 42(7) (7), 1517 - 1525, English, International magazine

  [Refereed]

  Scientific journal


• Patients with a Dorr type C femoral bone require attention for using a Summit cementless stem: Results of total hip arthroplasty after a minimum follow-up period of 5 years after insertion of a Summit cementless stem

  Masanori Tsubosaka, Shinya Hayashi, Shingo Hashimoto, Koji Takayama, Ryosuke Kuroda, Tomoyuki Matsumoto

  Elsevier, Jul. 2018, Journal of Orthopaedic Science, 23(4) (4), 671 - 675, English

  [Refereed]

  Scientific journal


• Development and Function of the Drosophila Tracheal System

  Hayashi Shinya, Kondo T

  Jun. 2018, Genetics, 209(2) (2), 367 - 380, English

  [Refereed]

  Scientific journal


• Exercise therapy interventions in patients with hip osteoarthritis: Comparison of the effects of DVD and website-based interventions

  Yuko Uesugi, Junichiro Koyanagi, Keishi Takagi, Ryota Yamaguchi, Shinya Hayashi, Takashi Nishii

  Journal of Medical Internet Research, May 2018, Journal of Medical Internet Research, 20(5) (5), English

  [Refereed]

  Scientific journal


• The Influence of Ruptured Scar Pattern on the Healing Potential of Anterior Cruciate Ligament Remnant Cells

  Shinsuke Kirizuki, Tomoyuki Matsumoto, Takeshi Ueha, Atsuo Uefuji, Takao Inokuchi, Koji Takayama, Shingo Hashimoto, Shinya Hayashi, Takehiko Matsushita, Ryosuke Kuroda

  SAGE Publications Inc., May 2018, American Journal of Sports Medicine, 46(6) (6), 1382 - 1388, English

  [Refereed]

  Scientific journal


• Exercise Therapy Interventions in Patients With Hip Osteoarthritis:Comparison of the Effects of DVD and Website-Based Interventions

  UESUGI YUKO, Junichiro Koyanagi, Keishi Takagi, Ryota Yamaguchi, Shinya Hayashi, Takashi Nishii

  May 2018, JMIR Rehabil Assist Technol, 5(1) (1), e10, English

  [Refereed]

  Scientific journal


• Depletion of aquaporin 1 decreased ADAMTS-4 expression in human chondrocytes

  Masahiko Haneda, Shinya Hayashi, Tomoyuki Matsumoto, Shingo Hashimoto, Koji Takayama, Nobuaki Chinzei, Shinsuke Kihara, Kazuhiro Takeuchi, Kotaro Nishida, Ryosuke Kuroda

  Spandidos Publications, Apr. 2018, Molecular Medicine Reports, 17(4) (4), 4874 - 4882, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• RA患者においてデノスマブによる骨粗鬆症治療は患者QOLを改善する

  福田 康治, 林 申也, 寛島 佑史, 本田 久樹, 西本 華子, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2018, 中部日本整形外科災害外科学会雑誌, 61(春季学会) (春季学会), 331 - 331, Japanese

  [Refereed]


• 関節リウマチの病因・病態1 関節リウマチ滑膜細胞におけるCadherin 2の発現はDecoy receptor 3により誘導される

  福田 康治, 三浦 靖史, 前田 俊恒, 林 申也, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2018, 日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 477 - 477, Japanese

  [Refereed]


• 関節リウマチの病因・病態2 関節リウマチ患者における関節破壊進行の予測はSNPs解析で可能である 多施設コホート研究

  林 申也, 松原 司, 児矢野 聡, 舟橋 恵子, 福田 康治, 酒井 良忠, 黒田 良祐, 奥田 康介, 佐川 昭, 松野 博明, 泉原 智磨, 生野 英祐

  (一社)日本リウマチ学会, Mar. 2018, 日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 498 - 498, Japanese

  [Refereed]


• 関節リウマチの治療12:病理・病態・バイオマーカー 生物学的製剤治療中のRA患者における単純ヘルペスおよび帯状疱疹ヘルペス発症に関わる遺伝子多型性の検討

  福田 康治, 松原 司, 児矢野 聡, 舟橋 恵子, 奥田 康介, 林 申也, 酒井 良忠, 黒田 良祐, 佐川 昭, 松野 博明, 泉原 智麿, 生野 英祐

  (一社)日本リウマチ学会, Mar. 2018, 日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 569 - 569, Japanese

  [Refereed]


• 生物学的製剤の治療継続率の比較 追跡期間10年を超える症例を対象とする

  福田 康治, 松原 司, 舟橋 恵子, 児矢野 聡, 伊丹 哲, 奥田 康介, 林 申也, 酒井 良忠, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2018, 日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 790 - 790, Japanese

  [Refereed]


• Quality of life of patients with osteonecrosis of the femoral head: a multicentre study.

  UESUGI YUKO, Sakai T, Seki T, Hayashi Shinya, Nakamura J, Inaba Y, Takahashi D, Sasaki K, Motomura G, Mashima N, Kabata T, Sudo A, Jinno T, Ando W, Nagoya S, Yamamoto K, Nakasone S, Ito H, Yamamoto T, Sugano N

  Mar. 2018, International Orthopaedic, doi: 10.1007/s00264-018-3897-8, English

  [Refereed]

  Scientific journal


• Decoy receptor 3 down-regulates centrosomal protein 70 kDa specifically in rheumatoid synovial fibroblasts.

  Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Ryosuke Kuroda

  OBJECTIVES: Decoy receptor 3 (DcR3) competitively binds to Fas ligand, lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells (LIGHT) and TNF-like ligand 1A (TL1A), thereby preventing their effects. Using a microarray assay, we previously newly identified centrosomal protein 70 kDa (CEP70) as one of the genes whose expression in fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA-FLS) is reduced by DcR3. Here, we investigated the significance of DcR3 regulation of CEP70 for RA-FLS. METHODS: Synovial samples were obtained from RA patients who had never been treated with biologics and from osteoarthritis (OA) patients. CEP70 mRNA expression was quantified using RT-qPCR analysis. CEP70 protein expression was assessed using immunohistochemical and western blot analyses. RESULTS: CEP70 was expressed predominantly in the superficial lining layer in RA synovial tissue. CEP70 expression was dose-dependently downregulated by DcR3-Fc in RA-FLS but was not downregulated in OA-FLS. TL1A antibody prevented the DcR3-Fc inhibitory effects on CEP70 expression in RA-FLS. CONCLUSIONS: These results indicated that DcR3 reduces CEP70 expression in RA-FLS by binding to membrane-bound TL1A and may suppress RA-FLS proliferation. The reduction in CEP70 expression by DcR3/TL1A signaling may control the hyperplasia of RA synovium.

  Mar. 2018, Modern rheumatology, 28(2) (2), 287 - 292, English, International magazine

  [Refereed]

  Scientific journal


• Prothrombin time-international normalized ratio is a useful marker for edoxaban efficacy in preventing venous thromboembolism after total knee arthroplasty

  Kazuki Kodato, Kazunari Ishida, Nao Shibanuma, Akihiko Toda, Koji Takayama, Shinya Oka, Shinya Hayashi, Shingo Hashimoto, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  Springer-Verlag France, Jan. 2018, European Journal of Orthopaedic Surgery and Traumatology, 28(1) (1), 103 - 108, English

  [Refereed]

  Scientific journal


• Consecutive Bilateral Hip Arthroscopy for Symptomatic Bilateral Femoroacetabular Impingement in an Elite Rugby player: A Case Report

  Nobuaki Chinzei, Shingo Hashimoto, Shinya Hayashi, Noriyuki Kanzaki, Daisuke Araki, Ryosuke Kuroda, Masahiro Kurosaka

  Dec. 2017, JOURNAL OF NIPPON MEDICAL SCHOOL, 84(6) (6), 280 - 285, English

  [Refereed]

  Scientific journal


• Anthology Hip SystemのDEXAによる術後2年の骨密度変化の検討

  竹内一裕, 橋本慎吾, 松本知之, Hayashi Shinya, 高山孝治, 木原伸介, 井口高雄, 桐月伸輔, 羽田勝彦, 黒田雄一, Kuroda Ryosuke

  Dec. 2017, 日本人工関節学会誌, 47, 643 - 644, Japanese

  [Refereed]

  Research society


• Arthroscopic Debridement of a Talar Cyst and Bone Grafting with the Osteochondral Autograft Transfer System A Case Report

  Nobuaki Chinzei, Noriyuki Kanzaki, Takaaki Fujishiro, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka

  Nov. 2017, JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION, 107(6) (6), 541 - 547, English

  [Refereed]

  Scientific journal


• The medial tibial joint line elevation over 5 mm restrained the improvement of knee extension angle in unicompartmental knee arthroplasty

  IshidaK, MuratsuH, KurodaY, TsubosakaM, Hashimoto Shingo, Hayashi Shinya, MatsushitaT, Niikura Takahiro, Kuroda Ryosuke, Matsumoto Tomoyuki

  PURPOSE: The purpose of this study was to examine the relationship between medial tibial joint line elevation and the improvement of range of motion (ROM) in unicompartmental knee arthroplasty (UKA). The hypothesis was that limited elevation of tibial joint line will improve knee range of motion in UKA. METHODS: Forty-six consecutive medial UKAs were enrolled in this study. Medial tibial joint line elevation was defined as the polyethylene insert and tibial tray thickness minus the tibial osteotomy and sawblade thickness. Positive values indicated an elevation of the tibial joint line. A component gap between the femoral trial prosthesis and the medial tibial osteotomy surface was also examined. Joint loosening was also calculated based on the joint component gap minus insert and tibial tray thickness. The correlation of the medial tibial joint line elevation with joint looseness and postoperative range of motion were analyzed. RESULTS: The mean medial tibial joint line elevation was 4.9 ± 1.1 mm. The medial tibial joint line elevation reduced the improvement of knee extension (R = - 0.43, p < 0.01). The medial tibial joint line elevation was also correlated with reduced loosening of the joint knee extension (R = - 0.42, p < 0.01). This, in turn, resulted in limited improvement of the knee extension angle. Moreover, joint line elevation under 5 mm significantly improved knee extension angle compared to joint line elevation over 5 mm. CONCLUSIONS: The medial joint line elevation of the tibia in UKA reduced the improvement of knee extension angle, due to a reduced joint looseness at knee extension. A tibial joint line elevation greater than 5 mm in UKA should be avoided to prevent postoperative flexion contracture. For the clinical relevance, this study clarified that the medial joint line of the tibia is an important factor to prevent postoperative flexion contracture in UKA. LEVEL OF EVIDENCE: II.

  Nov. 2017, Knee Surg Sports Traumatol Arthrosc, 26(6) (6), 1737 - 1742, English, International magazine

  [Refereed]

  Scientific journal


• Radiographic analysis of the lower limbs using the hipcalcaneus line in healthy individuals and in patients with varus knee osteoarthritis

  Toshikazu Tanaka, Koji Takayama, Shingo Hashimoto, Noriyuki Kanzaki, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  Oct. 2017, KNEE, 24(5) (5), 1146 - 1152, English

  [Refereed]

  Scientific journal


• Decoy receptor 3は関節リウマチ滑膜細胞におけるCentrosomal protein 70kDaの発現を抑制する

  福田 康治, 三浦 靖史, 前田 俊恒, 林 申也, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2017, 中部日本整形外科災害外科学会雑誌, 60(秋季学会) (秋季学会), 123 - 123, Japanese

  [Refereed]


• Stem anteversion mismatch to the anatomical anteversion causes loss of periprosthetic bone density after THA

  Hayashi Shinya, Hashimoto Shingo, Matsumoto Tomoyuki, TakayamaK, NishidaK, IshidaK, Kuroda Ryosuke

  Sep. 2017, J Orthop Surg (Hong Kong), 25(3) (3), 2309499017739478, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Risk factors for failure of revision total hip arthroplasty using a Kerboull-type acetabular reinforcement device

  Shinya Hayashi, Takayuki Nishiyama, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Kazunari Ishida, Kotaro Nishida, Ryosuke Kuroda

  Sep. 2017, BMC MUSCULOSKELETAL DISORDERS, 18(1) (1), 382, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 前十字靱帯損傷後の遺残組織の形態の差異が治癒特性に与える影響

  桐月 伸輔, 松本 知之, 黒田 雄一, 竹内 一裕, 羽田 勝彦, 井口 貴雄, 高山 孝治, 荒木 大輔, 橋本 慎吾, 林 申也, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1874 - S1874, Japanese


• 再置換術後日常活動性に影響する因子の検討

  Hayashi Shinya, 橋本慎吾, 木原伸介, 羽田勝彦, 竹内一裕

  Aug. 2017, Hip Joint, 43(1号) (1号), 238 - 242, Japanese

  [Refereed]

  Scientific journal


• Relatively Loose Flexion Gap Improves Patient-Reported Clinical Scores in Cruciate-Retaining Total Knee Arthroplasty

  Matsumoto Tomoyuki, MuratsuH, IshidaK, Hashimoto Shingo, Hayashi Shinya, Kuroda Ryosuke

  Although appropriate soft tissue balancing is well recognized as essential procedure in total knee arthroplasty (TKA), poor relationship between intraoperative soft tissue balance and physician-reported clinical outcomes was reported. Since physician-derived scores are reported to be poorly related to patient-reported scores, patient-derived outcome scales have received a great deal of attention and have become increasingly important. Thus, it should be clarified whether intraoperative soft tissue balance influences patient-reported clinical outcomes. Therefore, the purpose of this study was to investigate the relationship between intraoperative soft tissue balance and patient-reported clinical outcomes in TKA. A total of 35 TKAs were performed in patients with varus-type osteoarthritis, using the tibia first technique with a navigation system. Soft tissue balance (joint component gap and varus/valgus ligament balance) with femoral component placement and temporarily repaired patellofemoral joint were intraoperatively assessed with an offset-type tensor under 40 lb of joint distraction force. Measurements were performed at 0, 10, 30, 60, 90, and 120 degrees of knee flexion. Subjective clinical outcomes were assessed using the 2011 Knee Society score, which consists of objective knee indicators, patient satisfaction, patient expectations, and functional activities at the minimum 1-year follow-up. The relationship between each parameter in soft tissue balance and subjection clinical score was assessed using a simple linear regression model. Objective knee indicators, especially patient-reported symptoms, showed positive correlations with joint component gap difference of 90 to 0 and 120 to 0 degrees. Patient satisfaction and expectations also exhibited positive correlations with joint component gap difference of 90 to 0 and 120 to 0 degrees. There were no correlations among any parameters of soft tissue balance and functional activities. The other parameters, including varus/valgus ligament balance, showed no statistical correlations with clinical scores. In conclusion, intraoperative soft tissue balance influenced the postoperative clinical outcomes, where a relatively loose flexion gap resulted in higher scores for the parameters of pain, patient satisfaction, and patient expectations.

  Jul. 2017, J Knee Surg, 31(6) (6), 573 - 579, English, International magazine

  [Refereed]

  Scientific journal


• Multiple Revision Surgeries and Acetabular Bone Defect Size May Predict Daily Activity After Revision Total Hip Arthroplasty

  Shinya Hayashi, Shingo Hashimoto, Koji Takayama, Tomoyuki Matsumoto, Kotaro Nishida, Ryosuke Kuroda

  Churchill Livingstone Inc., May 2017, Journal of Arthroplasty, 32(5) (5), 1606 - 1611, English

  [Refereed]

  Scientific journal


• Cyclin-Dependent Kinase Inhibitor-1-Deficient Mice are Susceptible to Osteoarthritis Associated with Enhanced Inflammation

  Shinsuke Kihara, Shinya Hayashi, Shingo Hashimoto, Noriyuki Kanzaki, Koji Takayama, Tomoyuki Matsumoto, Nobuaki Chinzei, Kenjiro Iwasa, Masahiko Haneda, Kazuhiro Takeuchi, Kotaro Nishida, Ryosuke Kuroda

  John Wiley and Sons Inc., May 2017, Journal of Bone and Mineral Research, 32(5) (5), 991 - 1001, English

  [Refereed]

  Scientific journal


• New proximal femoral compaction blade provides strong antirotation stability of the femoral head

  Shinya Hayashi, Yukiaki Hirata, Daiki Okamoto, Satoshi Kakunai, Shingo Hashimoto, Koji Takayama, Tomoyuki Matsumoto, Takahiro Niikura, Takaaki Fujishiro, Takafumi Hiranaka, Kotaro Nishida, Ryosuke Kuroda

  Slack Incorporated, May 2017, Orthopedics, 40(3) (3), e491 - e494, English

  [Refereed]

  Scientific journal


• Radiological and clinical comparison of kinematically versus mechanically aligned total knee arthroplasty

  T. Matsumoto, K. Takayama, K. Ishida, S. Hayashi, S. Hashimoto, R. Kuroda

  May 2017, BONE & JOINT JOURNAL, 99-B(5) (5), 640 - 646, English

  [Refereed]

  Scientific journal


• Kinematically aligned total knee arthroplasty: Alternative standardized technique?

  Tomoyuki Matsumoto, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda

  AME Publishing Company, May 2017, Annals of Translational Medicine, 5(Suppl 1) (Suppl 1), S10, English

  [Refereed]

  Scientific journal


• Risk factors for late deep infection after total hip arthroplasty in patients with rheumatoid arthritis

  S. Hayashi, Y. Sakai, S. Hashimoto, K. Takayama, T. Matsumoto, K. Takebe, Y. Terashima, K. Ishida, K. Nishida, R. Kuroda

  Apr. 2017, ACTA REUMATOLOGICA PORTUGUESA, 42(2) (2), 150 - 154, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• リウマチ性疾患の基礎研究/サイトカイン・ケモカイン リウマチ滑膜の低ミトコンドリア生合成は滑膜増殖を亢進させ関節破壊の誘導に寄与する

  上羽 岳志, 酒井 良忠, 前田 俊恒, 西本 華子, 林 申也, 橋本 慎吾, 福田 康治, 三浦 靖史, 黒坂 昌弘, 柱本 照, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2017, 日本リウマチ学会総会・学術集会プログラム・抄録集, 61回, 589 - 589, Japanese

  [Refereed]


• FasLによるリウマチ滑膜線維芽細胞における遺伝子発現誘導の検討

  前田 俊恒, 三浦 靖史, 福田 康治, 林 申也, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2017, 日本リウマチ学会総会・学術集会プログラム・抄録集, 61回, 719 - 719, Japanese

  [Refereed]


• 人工足関節全置換術患者における術後早期の身体機能の推移

  松野凌馬, 上田雄也, 山口良太, 市橋康佑, 中村瑠美, Kanzaki Noriyuki, Hayashi Shinya, 橋本慎吾, 丸山孝樹, 酒井良忠

  国立大学リハビリテーション療法士協議会, Mar. 2017, 国立大学リハビリテーション療法士学術大会誌, 38回(38回) (38回), 44 - 48, Japanese

  [Refereed]

  Research society


• Mobile Bearing Total Knee Arthroplasty for Valgus Knee Osteoarthritis with Permanent Patellar Dislocation: A Case Report and Review of the Literature

  KamadaK, Matsumoto Tomoyuki, TakayamaK, ArakiD, Hashimoto Shingo, Hayashi Shinya, Matsushita Takehiko, Kuroda Ryosuke

  Permanent patellar dislocation with tibiofemoral joint osteoarthritis is a relatively rare condition. To treat this condition, total knee arthroplasty with proximal or distal realignment of the extensor mechanism has been reported. We report a challenging case of an 80-year-old woman diagnosed with permanent patellar dislocation with tibiofemoral joint osteoarthritis treated by a mobile bearing total knee arthroplasty utilizing navigation system. Lateral retinaculum release was performed to improve patellar tracking; other proximal or distal realignment of the extensor mechanism was not necessary. Postoperative radiographs show stable patellar tracking and recurrent patellar dislocation was not observed. This clinical case indicates that the implant's precise alignment and rotation during total knee arthroplasty could settle anatomical abnormalities of permanent patellar dislocation and the mobile bearing insert could contribute to stabilizing patellar tracking.

  2017, Case Rep Orthop, 2017, 1230412 - 1230412, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 人工股関節全置換術後感染患者の機能的予後 人工関節温存術・二期的再置換術を施行した5症例の検討

  中村 瑠美, 山口 良太, 林 申也, 橋本 慎吾, 神崎 至幸, 松野 凌馬, 市橋 康佑, 丸山 孝樹, 酒井 良忠

  (公社)日本理学療法士協会, Oct. 2016, 理学療法学, 43(Suppl.2) (Suppl.2), P - 2, Japanese


• 人工足関節全置換術患者における術前後の身体機能の変化 術後の最大歩行速度に関連する因子の検討

  市橋 康佑, 上田 雄也, 松野 凌馬, 中村 瑠美, 神崎 至幸, 林 申也, 橋本 慎吾, 丸山 孝樹, 酒井 良忠

  (公社)日本理学療法士協会, Oct. 2016, 理学療法学, 43(Suppl.2) (Suppl.2), O - 2, Japanese


• 人工股関節置換術後のステム周囲の骨密度は術後の活動性と相関する

  Kanzaki Noriyuki, Hayashi Shinya, 羽田勝彦, 橋本慎吾, 木原伸介, 竹内一裕, 茨木一行, Kuroda Ryosuke

  Sep. 2016, 日本骨粗鬆症学会雑誌, 2(Suppl.1) (Suppl.1), 222, Japanese

  Research society


• Summit stem使用症例の中期成績

  熊谷直利, Hayashi Shinya, 橋本慎吾, Kanzaki Noriyuki, Kuroda Ryosuke

  Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 237, Japanese

  Research society


• 足関節外側靱帯損傷に対する治療戦略 新鮮足関節外側靱帯損傷に対する治療の第1選択は保存療法である

  Kanzaki Noriyuki, 林申也, 橋本慎吾, 茨木一行, Kuroda Ryosuke

  Aug. 2016, 日本整形外科スポーツ医学会雑誌, 36(4号) (4号), 329, Japanese

  Research society


• 正常ヒト関節軟骨細胞におけるAQP9の検討

  竹内一裕, Hayashi Shinya, 橋本慎吾, Kanzaki Noriyuki, 木原伸介, 羽田勝彦

  Aug. 2016, 日本整形外科学会雑誌, 90(8号) (8号), S1768, Japanese

  [Refereed]

  Research society


• ミトコンドリア生合成亢進がリウマチ滑膜の細胞増殖と関節破壊に与える影響

  上羽岳志, Sakai Yoshitada, 前田俊恒, 森下雅之, Hayashi Shinya, 西本華子, 井上美帆, 原田理沙, 福田康治, 三浦靖史, Kuroda Ryosuke, 黒坂昌弘

  (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1421 - S1421, Japanese

  [Refereed]

  Research society


• エイコサペンタエン酸は酸化ストレス依存性の軟骨細胞の変性、アポトーシスを抑制する

  木原伸介, Hayashi Shinya, 明石祐典, 永田純平, 竹内一裕, 羽田勝彦, 橋本慎吾, Kanzaki Noriyuki, Kuroda Ryosuke, 田畑泰彦, 黒坂昌弘

  Aug. 2016, 日本整形外科学会雑誌, 90(8号) (8号), S1470, Japanese

  [Refereed]

  Research society


• 関節リウマチ患者の骨粗鬆症に対する抗RANKL抗体製剤デノスマブの使用経験

  前田俊恒, Hayashi Shinya, 三浦靖史, Sakai Yoshitada, 黒田良祐, 黒坂昌弘

  Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I46, Japanese

  [Refereed]

  Research society


• Stem anteversion affects periprosthetic bone mineral density after total hip arthroplasty

  Shinya Hayashi, Shingo Hashimoto, Noriyuki Kanzaki, Ryosuke Kuroda, Masahiro Kurosaka

  Wichtig Publishing Srl, May 2016, HIP International, 26(3) (3), 260 - 264, English

  [Refereed]

  Scientific journal


• The effect of acetabular and femoral component version on dislocation in primary total hip arthroplasty

  Takaaki Fujishiro, Takafumi Hiranaka, Shingo Hashimoto, Shinya Hayashi, Masahiro Kurosaka, Taiki Kanno, Takeshi Masuda

  Apr. 2016, INTERNATIONAL ORTHOPAEDICS, 40(4) (4), 697 - 702, English

  [Refereed]

  Scientific journal


• Interleukin‑12B is upregulated by decoy receptor 3 in rheumatoid synovial fibroblasts.

  Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Masahiro Kurosaka

  Decoy receptor 3 (DcR3) competitively binds to three ligands, Fas ligand, lymphotoxin‑related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells and tumor necrosis factor‑like ligand 1A (TL1A), to prevent their effects. Recent studies have suggested that DcR3 directly affects cells as a ligand. Using a microarray assay, our group newly identified interleukin (IL)‑12B, which encodes the p40 subunit common to IL‑12 and IL‑23, as one of the genes for which expression in fibroblast‑like synoviocytes from patients with rheumatoid arthritis (RA‑FLS) is induced by DcR3. The present study demonstrated that IL‑12B mRNA expression was upregulated by DcR3‑Fc in RA‑FLS in a dose‑dependent manner, but not in OA‑FLS. IL‑12B p40 protein in RA‑FLS was increased when stimulated with DcR3‑Fc. Pre‑treatment with anti‑TL1A antibody suppressed the upregulation of IL‑12B mRNA in RA‑FLS stimulated with DcR3‑Fc. DcR3 mRNA expression in RA‑FLS was induced by IL‑23, but not by IL‑12. These results indicated that DcR3 may increase IL‑12 or IL‑23 by inducing IL‑12B p40 expression via membrane‑bound TL1A on RA‑FLS and that IL‑23 reciprocally induces DcR3 expression in RA‑FLS. DcR3 and IL‑23 may interact in a feedback loop that aggravates local inflammation in patients with RA.

  Apr. 2016, Molecular medicine reports, 13(4) (4), 3647 - 52, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• ミトコンドリア生合成の亢進はコラーゲン誘導性関節炎(CIA)マウスの関節破壊を抑制する

  上羽 岳志, 酒井 良忠, 前田 俊恒, 林 申也, 橋本 慎吾, 福田 康治, 三浦 靖史, 柱本 照, 黒田 良祐, 黒坂 昌弘

  (一社)日本リウマチ学会, Mar. 2016, 日本リウマチ学会総会・学術集会プログラム・抄録集, 60回, 489 - 489, Japanese

  [Refereed]


• 関節リウマチ滑膜細胞において、decoy receptor 3はcentrosomal protein 70kDaの発現を抑制する

  福田 康治, 三浦 靖史, 前田 俊恒, 林 申也, 黒坂 昌弘

  (一社)日本リウマチ学会, Mar. 2016, 日本リウマチ学会総会・学術集会プログラム・抄録集, 60回, 626 - 626, Japanese

  [Refereed]


• Surgical Management of Irreducible Dislocation of the Peroneus Longus Tendon A Case Report

  Nobuaki Chinzei, Noriyuki Kanzaki, Takaaki Fujishiro, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2016, JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION, 106(2) (2), 121 - 127, English

  [Refereed]

  Scientific journal


• 人工足関節置換術前の変形性足関節症の病期は術後の成績に影響があるか

  Kanzaki Noriyuki, 高倉義典, 高倉義幸, 竹内一裕, 羽田勝彦, 木原伸介, 橋本慎吾, 林申也, Kuroda Ryosuke, 黒坂昌弘

  Mar. 2016, 日本整形外科学会雑誌, 90(3号) (3号), S947, Japanese

  [Refereed]

  Research society


• 股関節鏡視下手術の適応と限界 単純X線学的指標から考察する股関節鏡視下手術の適応と限界

  橋本慎吾, Hayashi Shinya, Kanzaki Noriyuki, Kuroda Ryosuke, 黒坂昌弘

  Mar. 2016, 日本整形外科学会雑誌, 90(3号) (3号), S485, Japanese

  Research society


• 関節リウマチの病因・病態 リウマチ滑膜線維芽細胞におけるLIGHTによる遺伝子発現誘導の検討

  前田俊恒, 三浦靖史, 福田康治, Hayashi Shinya, 黒坂昌弘

  (一社)日本リウマチ学会, Mar. 2016, 日本リウマチ学会総会・学術集会プログラム・抄録集 60回, 60回, 471 - 471, Japanese

  Research society


• 関節リウマチの手術 下肢 関節リウマチ患者に対する人工股関節全置換術後遅発性感染を引き起こす因子の検討

  Hayashi Shinya, 酒井良忠, 橋本慎吾, Kanzaki Noriyuki, 前田俊恒, 三浦靖史, 上羽岳志, Kuroda Ryosuke, 黒坂昌弘

  Mar. 2016, 日本リウマチ学会総会・学術集会プログラム・抄録集 60回, 373, Japanese

  [Refereed]

  Research society


• Daily activity and initial bone mineral density are associated with periprosthetic bone mineral density after total hip arthroplasty

  Shinya Hayashi, Shingo Hashimoto, Noriyuki Kanzaki, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2016, HIP INTERNATIONAL, 26(2) (2), 169 - 174, English

  [Refereed]

  Scientific journal


• 人工足関節全置換術患者における術前後の身体機能の変化

  市橋 康佑, 上田 雄也, 松野 凌馬, 中村 瑠美, 神崎 至幸, 林 申也, 橋本 慎吾, 丸山 孝樹, 酒井 良忠

  【はじめに，目的】近年，人工足関節全置換術（TAA）は，重度な変形性足関節症や関節リウマチにより高度に破壊された足関節に対する治療法として，選択施行されている。TAAの長期予後として，優れた除痛効果と関節可動域（ROM）の温存ならび改善に優れると報告されている。しかし，TAA術前から術後早期に身体機能変化について検討したものは見当たらない。また，術後の最大歩行速度（MWS）の低下は，手段的日常生活動作の低下や転倒のリスク因子であると報告されている。しかし，TAA術後のMWSに関連する因子についての報告はない。そこで，本研究の目的は，TAA術前と術後3ヶ月の身体機能の変化を比較検討するとともに，術後のMWSに関連する因子について検討することとした。【方法】対象は，2014年4月～2015年7月の期間に当院整形外科にて，TAAを施行された13名13足（男性3名，女性10名，年齢75.6±6.0歳）とした。13足のうち，変形性足関節症が12足，関節リウマチが1足であった。測定項目として，以下の項目を術前と術後3ヶ月で測定した。（1）他動ROM：足関節背屈および底屈のROMを測定した。（2）疼痛：歩行時の足関節の痛みについてVisual analog scale（以下VAS）を用いて数値化した。（3）歩行速度：10m歩行路の歩行時間を測定し，MWS（m/分）を算出した。統計解析として，術前と術後3ヶ月の各測定項目についてPaired t-testを用いて比較した。また術後3ヶ月において，MWSと背屈ROM，底屈ROM，VASの関連についてPearsonの相関分析を用いて検討した。すべての統計解析にはJMPver11.0を用い，有意水準は5%とした。【結果】背屈ROMは術前3.5±4.3°から術後7.3±3.9と有意に改善したが，底屈ROMは31.5±8.3から30.7±10.0°と有意な変化を示さなかった。また，VASは69.8±18.6から37.0.±20.7，MWSは54.4±20.0m/分から69.6±18.4m/分と有意な改善を認めた。術後3ヶ月において，MWSと背屈ROM（r=0.71），底屈ROM（r=0.56），VAS（r=0.56）とそれぞれ有意な相関関係が認められた。【結論】TAA術後3ヶ月では，術前に比べ背屈ROM，歩行時のVAS，MWSに有意な改善を認めた。術後3ヶ月におけるMWSに関連する因子として，背屈ROM，底屈ROM，VASに関連があることが示唆された。

  公益社団法人 日本理学療法士協会, 2016, 理学療法学Supplement, 2015, 14 - 14, Japanese


• 人工股関節全置換術後感染患者の機能的予後

  中村 瑠美, 山口 良太, 林 申也, 橋本 慎吾, 神崎 至幸, 松野 凌馬, 市橋 康佑, 丸山 孝樹, 酒井 良忠

  【目的】人工股関節全置換術後感染（以下PJI）は長期治療を要する深刻な合併症である。PJIの鎮静化には抗菌薬治療と病巣掻爬・再置換等の外科的治療が必要であり，侵襲性の強い治療となる。近年，インプラントや抗菌薬の改良が進み，PJIの予防や診断，治療方法等に関する報告が散見される。一方で，PJI患者に対する理学療法や機能的予後に関して報告されたものは少ない。そこで本研究の目的は，当院にてPJI治療を施行し，自宅退院可能であった症例について検討することとした。【方法】対象は2012年4月～2015年10月当院にてPJIに対する治療をうけて自宅退院した10例10股のうち，永続的抜去術を施行された4例4股，PJI発症前より歩行困難であった1例を除外した5例5股（男性1例，女性4例：平均年齢69歳）とした。電子診療録より，PJI治療方法・最終人工股関節全置換術（以下THA）からPJI発症までの期間・基礎疾患・免荷期間・在院日数・発症前および退院時の歩行様式を後方視的に採取し検討した。【結果】人工股関節温存術（病巣掻爬＋抗菌薬治療）3例，二期的再置換術（人工関節抜去＋抗菌薬治療→再置換）2例であった。PJI発症までの期間は，3ヶ月以内の早期感染3例，1年以上の遅延感染2例，基礎疾患は関節リウマチ（以下RA）3例であった。全例において，発症前・退院時の歩行様式に変化なく退院可能であった。以下に6例の要約を示す。＜症例1，2＞順に76歳・85歳女性。基礎疾患にRAあり。PJI発症は順に術後4年・1か月半。温存術施行。2例ともに杖歩行で自宅退院。在院日数56日・67日であった。＜症例3＞33歳男性。特発性大腿骨頭壊死に対しTHA施行。術後1ヶ月でPJI発症し温存術施行。杖歩行で自宅退院。在院日数30日であった。＜症例4＞74歳女性。基礎疾患にRAあり。THA術後4年半で初回PJI発症，温存術で軽快するも1年半後に再燃，二期的再置換術施行。免荷期間61日。再置換術後3日より全荷重で歩行練習開始。術後21日で杖歩行自立，術後34日で自宅退院。在院日数96日であった。＜症例5＞77歳女性。基礎疾患なし。変形性股関節症に対し他院でTHA施行。術後13日でPJI発症。温存術で鎮静化せず当院転院，二期的再置換術施行。免荷期間101日。再置換術後3日より全荷重で歩行練習開始。術後35日で杖歩行自立，術後44日で自宅退院。PJI発症からの在院日数167日であった。【結論】本研究の結果より，PJIに対する温存術・二期的再置換術施行患者において，PJI治療後歩行様式が維持できる可能性が示唆された。温存術と異なり，長期免荷期間を要する二期的再置換術患者においては，免荷期間中の機能維持が理学療法の課題であると考えられる。今後は，PJIの外科的治療や免荷による下肢機能への影響を明らかにし，PJI患者に対するより効果的な理学療法の検討が望ましい。本研究結果は，今後増加すると予測されるPJI患者に対する理学療法への一助となると考えられる。

  公益社団法人 日本理学療法士協会, 2016, 理学療法学Supplement, 2015, 134 - 134, Japanese


• Inflammation and Degeneration in Cartilage Samples from Patients with Femoroacetabular Impingement

  Nobuaki Chinzei, Shingo Hashimoto, Takaaki Fujishiro, Shinya Hayashi, Noriyuki Kanzaki, Soshi Uchida, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2016, JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 98(2) (2), 135 - 141, English

  [Refereed]

  Scientific journal


• エイコサペンタエン酸は軟骨細胞の変性と変形性関節症の進行を抑制する

  木原伸介, Hayashi Shinya, 明石祐典, 永田純平, 竹内裕一, 羽田勝彦, 鎮西伸顕, Kanzaki Noriyuki, 橋本慎吾, Kuroda Ryosuke, 田畑泰彦, Kurosaka Masahiro

  Nov. 2015, 日本バイオマテリアル学会大会予稿集 37回, 333, Japanese

  [Refereed]

  Research society


• p21 deficiency is susceptible to osteoarthritis through STAT3 phosphorylation

  Shinya Hayashi, Takaaki Fujishiro, Shingo Hashimoto, Noriyuki Kanzaki, Nobuaki Chinzei, Shinsuke Kihara, Koji Takayama, Tomoyuki Matsumoto, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda

  Nov. 2015, ARTHRITIS RESEARCH & THERAPY, 17, 314, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Decoy receptor 3 regulates the expression of tryptophan hydroxylase 1 in rheumatoid synovial fibroblasts.

  Toshihisa Maeda, Yasushi Miura, Koji Fukuda, Shinya Hayashi, Masahiro Kurosaka

  Decoy receptor 3 (DcR3) is expressed in rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLS) and downregulates the expression of tryptophan hydroxylase 1 (TPH1), which is the rate‑limiting enzyme in serotonin synthesis. The aim of the present study was to determine the specificity of the effects of DcR3 on TPH1 in RA‑FLS, and therefore determine whether DcR3 had the potential to modulate the pathogenesis of RA. The present study also aimed to compare the effects of DcR3 and inflammatory cytokines on the expression of TPH1 in RA‑FLS and osteoarthritis (OA)‑FLS. Primary cultured RA‑ or OA‑FLS were incubated with 1.0 µg/ml DcR3‑Fc protein or 1.0 µg/ml control immunoglobulin G (IgG)1 for 12 h, or with 1.0 ng/ml tumor necrosis factor (TNF)α, 1.0 ng/ml interleukin (IL)‑1β or serum‑free Opti‑MEM only, for 24 h. The relative mRNA expression levels of TPH1 were subsequently quantified using reverse transcription‑polymerase chain reaction. The expression of serotonin in RA or OA synovial tissue was detected using immunohistochemistry. The mRNA expression of TPH1 was observed in both RA‑ and OA‑FLS and was significantly decreased following treatment with DcR3 in the RA‑FLS, however, not in the OA‑FLS. The mRNA expression of TPH1 was significantly decreased following treatment with TNFα or IL‑1β in both the RA‑ and OA‑FLS. The expression of serotonin in the multi‑layered lining synovial cells of RA and the outer layer lining synovial cells of OA was detected using immunohistochemistry. The present study is the first, to the best of our knowledge, to demonstrate that the expression of TPH1 in FLS is downregulated by inflammatory cytokines, and that DcR3 suppressed the expression of TPH1 in RA‑FLS in a disease‑specific manner. These results suggested that synovial serotonin may be involved in the pathogenesis of RA, and that TPH1 and DcR3 may be potential therapeutic targets for the treatment of RA.

  Oct. 2015, Molecular medicine reports, 12(4) (4), 5191 - 6, English, International magazine

  [Refereed]

  Scientific journal


• Late onset prosthetic hip joint infection in two patients of rheumatoid arthritis treated with etanercept

  Hayashi Shinya, Sakai Yoshitada, Fujishiro Takaaki, Hashimoto Shingo, Kanzaki Noriyuki, Kuroda Ryosuke, Kurosaka Masahiro

  Turkish League Against Rheumatism (TLAR), Sep. 2015, Archives of Rheumatology, 30(2) (2), 168 - 171, English

  [Refereed]

  Scientific journal


• TL1Aによるリウマチ滑膜線維芽細胞における遺伝子発現誘導の検討

  前田俊恒, 三浦靖史, 福田康治, Hayashi Shinya, Kurosaka Masahiro

  (公社)日本整形外科学会, Sep. 2015, 日本整形外科学会雑誌, 89(8) (8), S1599 - S1599, Japanese

  [Refereed]

  Research society


• p21欠損は炎症による変形性関節症を加速させる

  木原伸介, Hayashi Shinya, 藤代高明, Kanzaki Noriyuki, 橋本慎吾, 鎮西伸顕, 羽田勝彦, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2015, 日本整形外科学会雑誌, 89(8号) (8号), S1535, Japanese

  [Refereed]

  Research society


• P21遺伝子はマウス筋損傷モデルにおいて細胞増殖および筋分化を調節する

  鎮西伸顕, Hayashi Shinya, 上羽岳志, 藤代高明, Kanzaki Noriyuki, 橋本慎吾, 木原伸介, 羽田勝彦, Sakai Yoshitada, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2015, 日本整形外科学会雑誌, 89(8号) (8号), S1503, Japanese

  [Refereed]

  Research society


• 抗RANKL抗体製剤デノスマブ治療における骨粗鬆症患者の骨代謝マーカーおよびQOLの検討

  前田俊恒, 林申也, 三浦靖史, Sakai Yoshitada, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2015, Osteoporosis Japan, 23(Suppl.1) (Suppl.1), 269, Japanese

  [Refereed]

  Research society


• 抗RANKL抗体製剤デノスマブは骨粗鬆症患者のQOLを向上させる

  前田俊恒, Hayashi Shinya, 三浦靖史, Sakai Yoshitada, Kuroda Ryosuke, Kurosaka Masahiro

  Jul. 2015, 日本骨代謝学会学術集会プログラム抄録集, (33回) (33回), 220, Japanese

  [Refereed]

  Research society


• 足部インピンジメント症候群 AAIS、PAIS以外の足部インピンジメント症候群に対する足部内視鏡手術

  Kanzaki Noriyuki, 熊井司, 田中康仁, 藤代高明, Hayashi Shinya, 橋本慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  Jun. 2015, JOSKAS, 40(4号) (4号), 131, Japanese

  [Refereed]

  Research society


• Tibialis spastic varus foot without tarsal coalition: a report of two cases

  Noriyuki Kanzaki, Takayuki Nishiyama, Yoshiyuki Takakura, Yoshinori Takakura, Takaaki Fujishiro, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka

  Springer Tokyo, May 2015, Journal of Orthopaedic Science, 20(3) (3), 551 - 554, English

  [Refereed]

  Scientific journal


• 様々な病態が重なり整復不能となった長腓骨筋腱脱臼の1例

  鎮西伸顕, Kanzaki Noriyuki, Hayashi Shinya, 木原伸介, 羽田勝彦, 酒井良忠, 秋末敏宏, 西山隆之, Kuroda Ryosuke, Kurosaka Masahiro

  May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S254, Japanese

  Research society


• 抗RANKL抗体製剤デノスマブは骨粗鬆症患者のQOLを向上させる

  前田俊恒, Hayashi Shinya, 三浦靖史, 酒井良忠, Kuroda Ryosuke, Kurosaka Masahiro

  May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S225, Japanese

  Research society


• 筋損傷後の治癒過程におけるp21の役割

  鎮西伸顕, Hayashi Shinya, Kanzaki Noriyuki, 上羽岳志, 木原伸介, 羽田勝彦, 酒井良忠, 秋末敏宏, Kuroda Ryosuke, Kurosaka Masahiro

  May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S208, Japanese

  Research society


• デノスマブによる骨粗鬆症治療の治療効果

  Hayashi Shinya, 前田俊恒, 三浦靖史, 酒井良忠, Kuroda Ryosuke, Kurosaka Masahiro

  May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S225, Japanese

  Research society


• Tri-Lock Bone Preservation StemのDEXAによる術後骨密度変化の検討

  羽田勝彦, Hayashi Shinya, Kanzaki Noriyuki, 鎮西伸顕, 木原伸介, 酒井良忠, 秋末敏宏, Kuroda Ryosuke, Kurosaka Masahiro

  May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S370, Japanese

  Research society


• P21 Deficiency Delays Regeneration of Skeletal Muscular Tissue

  Nobuaki Chinzei, Shinya Hayashi, Takeshi Ueha, Takaaki Fujishiro, Noriyuki Kanzaki, Shingo Hashimoto, Shuhei Sakata, Shinsuke Kihara, Masahiko Haneda, Yoshitada Sakai, Ryosuke Kuroda, Masahiro Kurosaka

  May 2015, PLOS ONE, 10(5) (5), e0125765, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The contributing factors of tapered wedge stem alignment during mini-invasive total hip arthroplasty

  Shinya Hayashi, Takaaki Fujishiro, Shingo Hashimoto, Noriyuki Kanzaki, Ryosuke Kuroda, Masahiro Kurosaka

  Apr. 2015, Journal of Orthopaedic Surgery and Research, 10, 52, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Centrosomal protein 70kDaはdecoy receptor 3により関節リウマチ滑膜細胞に特異的に発現が抑制される

  福田 康治, 三浦 靖史, 前田 俊恒, 林 申也, 黒坂 昌弘

  (一社)日本リウマチ学会, Mar. 2015, 日本リウマチ学会総会・学術集会プログラム・抄録集, 59回, 480 - 480, Japanese

  [Refereed]


• TL1Aによるリウマチ滑膜線維芽細胞における遺伝子発現誘導の検討

  前田俊恒, 三浦靖史, 福田康治, Hayashi Shinya, Kurosaka Masahiro

  (一社)日本リウマチ学会, Mar. 2015, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 59回, 59回, 480 - 480, Japanese

  [Refereed]

  Research society


• RA滑膜細胞のミトコンドリア活性化は細胞増殖とMMP-3/RANKLの分泌を抑制する

  上羽岳志, Sakai Yoshitada, 前田俊恒, 福田康治, Hayashi Shinya, 小林慶通, 柱本照, 三浦靖史, Kurosaka Masahiro

  (一社)日本リウマチ学会, Mar. 2015, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 59回, 59回, 479 - 479, Japanese

  [Refereed]

  Research society


• Oxidative Stress-induced Apoptosis and Matrix Loss of Chondrocytes Is Inhibited by Eicosapentaenoic Acid

  Shuhei Sakata, Shinya Hayashi, Takaaki Fujishiro, Kohei Kawakita, Noriyuki Kanzaki, Shingo Hashimoto, Kenjiro Iwasa, Nobuaki Chinzei, Shinsuke Kihara, Masahiko Haneda, Takeshi Ueha, Takayuki Nishiyama, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2015, JOURNAL OF ORTHOPAEDIC RESEARCH, 33(3) (3), 359 - 365, English

  [Refereed]

  Scientific journal


• DcR3は関節リウマチ滑膜線維芽細胞におけるトリプトファン水酸化酵素TPH1の発現を制御する

  前田俊恒, 三浦靖史, 福田康治, Hayashi Shinya, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Mar. 2015, 中部日本整形外科災害外科学会雑誌, 58(春季学会) (春季学会), 178 - 178, Japanese

  [Refereed]

  Research society


• Cyclin-dependent kinase inhibitor p21 does not impact embryonic endochondral ossification in mice

  Nobuaki Chinzei, Shinya Hayashi, Shingo Hashimoto, Noriyuki Kanzaki, Kenjiro Iwasa, Shuhei Sakata, Shinsuke Kihara, Takaaki Fujishiro, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2015, MOLECULAR MEDICINE REPORTS, 11(3) (3), 1601 - 1608, English

  [Refereed]

  Scientific journal


• Late Onset Prosthetic Hip Joint Infection in Two Patients of Rheumatoid Arthritis Treated With Etanercept

  Hayashi Shinya, Sakai Yoshitada, Fujishiro Takaaki, Hashimoto Shingo, Kanzaki Noriyuki, Kuroda Ryosuke, Kurosaka Masahiro

  2015, ARCHIVES OF RHEUMATOLOGY, 30(2) (2), 168 - 171, English

  [Refereed]

  Scientific journal


• Surgical Management of the Peroneus Quartus Muscle for Bilateral Ankle Pain A Case Report

  Nobuaki Chinzei, Noriyuki Kanzaki, Yoshinori Takakura, Yoshiyuki Takakura, Akihiko Toda, Takaaki Fujishiro, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2015, JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION, 105(1) (1), 85 - 91, English

  [Refereed]

  Scientific journal


• painDETECT による股関節疾患患者の神経障害性疼痛の実態調査

  Uesugi Yuko, HAYASHI SHINYA, HASHIMOTO SHINGO, 藤代 高明, 西井 孝, 西山 隆之

  2015, Hip Joint, 4, 125 - 127, Japanese

  Scientific journal


• Accurate and easy measurement of sliding distance of intramedullary nail in trochanteric fracture

  Nobuaki Chinzei, Takafumi Hiranaka, Takahiro Niikura, Takaaki Fujishiro, Shinya Hayashi, Noriyuki Kanzaki, Shingo Hashimoto, Yoshitada Sakai, Ryosuke Kuroda, Masahiro Kurosaka

  Korean Orthopaedic Association, 2015, CiOS Clinics in Orthopedic Surgery, 7(2) (2), 152 - 157, English

  [Refereed]

  Scientific journal


• 筋損傷後の治癒過程におけるp21の役割

  木原 伸介, Hayashi Shinya, 上羽 岳志, 橋本 慎吾, Fujishiro Takaaki, Kanzaki Noriyuki, 鎮西 伸顕, 坂田 周平, 酒井 良忠, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2014, 日本整形外科学会雑誌, 88(8号) (8号), S1576, Japanese

  [Refereed]

  Research society


• Clinical importance of impingement deformities for hip osteoarthritis progression in a Japanese population

  Shingo Hashimoto, Takaaki Fujishiro, Shinya Hayashi, Noriyuki Kanzaki, Takayuki Nishiyama, Masahiro Kurosaka

  Aug. 2014, INTERNATIONAL ORTHOPAEDICS, 38(8) (8), 1609 - 1614, English

  [Refereed]

  Scientific journal


• 変形性足関節症の治療戦略:現状と未来 人工足関節置換術の現状と未来

  Kanzaki Noriyuki, 高倉 義典, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  Jul. 2014, JOSKAS, 39(4号) (4号), 307, Japanese

  [Refereed]

  Research society


• Effect of screw fixation on acetabular component alignment change in total hip arthroplasty

  Takaaki Fujishiro, Shinya Hayashi, Noriyuki Kanzaki, Shingo Hashimoto, Nao Shibanuma, Masahiro Kurosaka

  Jun. 2014, INTERNATIONAL ORTHOPAEDICS, 38(6) (6), 1155 - 1158, English

  [Refereed]

  Scientific journal


• 有症性の両側第4腓骨筋腱に対する治療経験

  鎮西 伸顕, Kanzaki Noriyuki, Hayashi Shinya, 木原 伸介, 酒井 良忠, 秋末 敏宏, Kuroda Ryosuke, Kurosaka Masahiro

  May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S308, Japanese

  [Refereed]

  Research society


• ディシジョンツリー分析を用いた人工股関節全置換術後在院日数予測モデルの構築(第2報)

  中村 瑠美, 山口 良太, 丸山 孝樹, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, 酒井 良忠

  May 2014, 理学療法学, 41(大会特別号2) (大会特別号2), 0125, Japanese

  [Refereed]

  Research society


• G2ステム使用症例の短中期成績

  鎮西 伸顕, Hayashi Shinya, Kanzaki Noriyuki, 木原 伸介, 酒井 良忠, 秋末 敏宏, Kuroda Ryosuke, Kurosaka Masahiro

  May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S305, Japanese

  [Refereed]

  Research society


• Computed tomographic measurement of acetabular and femoral component version in total hip arthroplasty

  Takaaki Fujishiro, Shinya Hayashi, Noriyuki Kanzaki, Shingo Hashimoto, Masahiro Kurosaka, Taiki Kanno, Takeshi Masuda

  May 2014, INTERNATIONAL ORTHOPAEDICS, 38(5) (5), 941 - 946, English

  [Refereed]

  Scientific journal


• Adverse reactions to metal debrisにより臼蓋コンポーネント周囲に巨大な骨欠損を生じた1例

  亀長 智幸, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, Kurosaka Masahiro

  May 2014, 中部日本整形外科災害外科学会雑誌, 57(3号) (3号), 677 - 678, Japanese

  [Refereed]

  Research society


• 足部インピンジメント症候群の診断と治療 足関節以外の足部インピンジメント症候群に対する足部内視鏡手術

  Kanzaki Noriyuki, 熊井 司, 田中 康仁, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2014, 日本整形外科学会雑誌, 88(2号) (2号), S417, Japanese

  [Refereed]

  Research society


• 青壮年期の股関節痛への対応 Femoroacetabular impingementに対する画像診断

  橋本 慎吾, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2014, 日本整形外科学会雑誌, 88(2号) (2号), S476, Japanese

  [Refereed]

  Research society


• 人工股関節再置換術の創意工夫 Kerboull型プレートを用いた人工股関節再置換術の術後成績

  Hayashi Shinya, Fujishiro Takaaki, Kanzaki Noriyuki, 橋本 慎吾, 西山 隆之, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2014, 日本整形外科学会雑誌, 88(2号) (2号), S463, Japanese

  [Refereed]

  Research society


• 人工股関節を適切な位置に設置するための術前・術後の評価 CT based fluoroscopic matching navigation systemを使用したTHAの大腿骨コンポーネント設置精度における検討

  Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2014, 日本整形外科学会雑誌, 88(2号) (2号), S473, Japanese

  Research society


• IL-12Bはdecoy receptor 3により関節リウマチ滑膜細胞に特異的に発現誘導される

  福田 康治, 三浦 靖史, 前田 俊恒, Hayashi Shinya, Kurosaka Masahiro

  (一社)日本リウマチ学会, Mar. 2014, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 58回, 58回, 674 - 674, Japanese

  [Refereed]

  Research society


• DcR3は関節リウマチ滑膜線維芽細胞におけるトリプトファン水酸化酵素TPH1の発現を制御する

  前田 俊恒, 三浦 靖史, 福田 康治, Hayashi Shinya, Kurosaka Masahiro

  (一社)日本リウマチ学会, Mar. 2014, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 58回, 58回, 674 - 674, Japanese

  [Refereed]

  Research society


• PTEN Regulates Matrix Synthesis in Adult Human Chondrocytes under Oxidative Stress

  Kenjiro Iwasa, Shinya Hayashi, Takaaki Fujishiro, Noriyuki Kanzaki, Shingo Hashimoto, Shuhei Sakata, Nobuaki Chinzei, Takayuki Nishiyama, Ryosuke Kuroda, Masahiro Kurosaka

  Feb. 2014, JOURNAL OF ORTHOPAEDIC RESEARCH, 32(2) (2), 231 - 237, English

  [Refereed]

  Scientific journal


• Arthroscopic ankle arthrodesis for treating osteoarthritis in a patient with kashin-beck disease

  Kenjiro Iwasa, Noriyuki Kanzaki, Takaaki Fujishiro, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka

  Hindawi Limited, 2014, Case Reports in Medicine, 2014, 931278, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Flexible hinge silicone implant with or without titanium grommets for arthroplasty of the first metatarsophalangeal joint

  Noriyuki Kanzaki, Takayuki Nishiyama, Takaaki Fujishiro, Shinya Hayash, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka

  2014, JOURNAL OF ORTHOPAEDIC SURGERY, 22(1) (1), 42 - 45, English

  [Refereed]

  Scientific journal


• 距骨に骨軟骨腫を生じた一例

  木原 伸介, 神崎 至幸, 秋末 敏弘, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke

  Oct. 2013, 日本足の外科学会雑誌, 34(2号) (2号), S278, Japanese

  Research society


• カシンベック病に伴う変形性足関節症に対し鏡視下足関節固定術をおこなった症例

  Fujishiro Takaaki, 神崎 至幸, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  Oct. 2013, 日本足の外科学会雑誌, 34(2号) (2号), S326, Japanese

  Research society


• TNK人工足関節置換術後の足関節可動域についての検討

  神崎 至幸, 高倉 義幸, 高倉 義典, 杜多 昭彦, 柴沼 均, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  Oct. 2013, 日本足の外科学会雑誌, 34(2号) (2号), S187, Japanese

  Research society


• Decoy receptor 3 regulates the expression of various genes in rheumatoid arthritis synovial fibroblasts.

  Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Masayasu Takahashi, Shinya Hayashi, Masahiro Kurosaka

  Decoy receptor 3 (DcR3), a member of the tumor necrosis factor (TNF) receptor (TNFR) superfamily, lacks the transmembrane domain of conventional TNFRs in order to be a secreted protein. DcR3 competitively binds and inhibits members of the TNF family, including Fas ligand (FasL), LIGHT and TNF-like ligand 1A (TL1A). We previously reported that TNFα-induced DcR3 overexpression in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) protects cells from Fas-induced apoptosis. Previous studies have suggested that DcR3 acting as a ligand directly induces the differentiation of macrophages into osteoclasts. Furthermore, we reported that DcR3 induces very late antigen-4 (VLA--4) expression in THP-1 macrophages, inhibiting cycloheximide-induced apoptosis and that DcR3 binds to membrane-bound TL1A expressed on RA-FLS, resulting in the negative regulation of cell proliferation induced by inflammatory cytokines. In the current study, we used cDNA microarray to search for genes in RA-FLS whose expression was regulated by the ligation of DcR3. The experiments revealed the expression profiles of genes in RA-FLS regulated by DcR3. The profiles showed that among the 100 genes most significantly regulated by DcR3, 45 were upregulated and 55 were downregulated. The upregulated genes were associated with protein complex assembly, cell motility, regulation of transcription, cellular protein catabolic processes, cell membrane, nucleotide binding and glycosylation. The downregulated genes were associated with transcription regulator activity, RNA biosynthetic processes, cytoskeleton, zinc finger region, protein complex assembly, phosphate metabolic processes, mitochondrion, ion transport, nucleotide binding and cell fractionation. Further study of the genes detected in the current study may provide insight into the pathogenesis and treatment of rheumatoid arthritis by DcR3-TL1A signaling.

  Oct. 2013, International journal of molecular medicine, 32(4) (4), 910 - 6, English, International magazine

  [Refereed]

  Scientific journal


• Automated pelvic anatomical coordinate system is reproducible for determination of anterior pelvic plane

  Shinya Hayashi, Takayuki Nishiyama, Takaaki Fujishiro, Noriyuki Kanzaki, Nao Shibanuma, Syoji Kobashi, Masahiro Kurosaka

  Sep. 2013, COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING, 16(9) (9), 937 - 942, English

  [Refereed]

  Scientific journal


• 全身静脈血サンプリングが診断に有用であった右手関節軟部腫瘍による腫瘍性骨軟化症の1例

  Kawamoto Teruya, Akisue Toshihiro, Hara Hitomi, 大西 康央, Hayashi Shinya, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Sep. 2013, 中部日本整形外科災害外科学会雑誌, 56(秋季学会) (秋季学会), 152 - 152, Japanese

  Research society


• Erratum to Effectiveness of distance education intervention using video footage in postoperative patients after total hip arthroplasty [International Journal of Orthopaedic and Trauma Nursing (2013) 17, 91-98]

  Yuko Uesugi, Shinya Hayashi, Takaaki Fujishiro, Noriyuki Kanzaki, Takayuki Nishiyama

  Aug. 2013, International Journal of Orthopaedic and Trauma Nursing, 17(3) (3), 168, English

  Scientific journal


• ヒト軟骨細胞においてPTENは酸化ストレス下に基質の産生を調整する

  岩佐 賢二郎, Hayashi Shinya, Fujishiro Takaaki, 神崎 至幸, 橋本 慎吾, 坂田 周平, 鎮西 伸顕, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2013, 日本整形外科学会雑誌, 87(8号) (8号), S1321, Japanese

  Research society


• エイコサペンタエン酸は酸化ストレス依存性の軟骨細胞の変性、アポトーシスを抑制する

  坂田 周平, Fujishiro Takaaki, Hayashi Shinya, 神崎 至幸, 橋本 慎吾, 岩佐 賢二郎, 鎮西 伸顕, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2013, 日本整形外科学会雑誌, 87(8号) (8号), S1322, Japanese

  Research society


• Excessive femoral offset does not affect the range of motion after total hip arthroplasty

  Shinya Hayashi, Takayuki Nishiyama, Takaaki Fujishiro, Shingo Hashimoto, Noriyuki Kanzaki, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Jul. 2013, International Orthopaedics, 37(7) (7), 1233 - 1237, English

  [Refereed]

  Scientific journal


• カシンベック病に伴う変形性足関節症に対し鏡視下足関節固定術をおこなった症例

  神崎 至幸, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  Jun. 2013, JOSKAS, 38(4号) (4号), 218, Japanese

  Research society


• Femoroacetabular Impingementにおける関節軟骨に対するT1rho MRIの診断意義

  橋本 慎吾, Fujishiro Takaaki, Hayashi Shinya, 神崎 至幸, 後藤 一, 岩間 祐基, 藤井 正彦, 西山 隆之, Kurosaka Masahiro

  Jun. 2013, JOSKAS, 38(4号) (4号), 422, Japanese

  [Refereed]

  Research society


• Evaluation of the accuracy of femoral component orientation by the CT-based fluoro-matched navigation system

  Shinya Hayashi, Takayuki Nishiyama, Takaaki Fujishiro, Shingo Hashimoto, Noriyuki Kanzaki, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2013, International Orthopaedics, 37(6) (6), 1063 - 1068, English

  [Refereed]

  Scientific journal


• Effectiveness of distance education intervention using video footage in postoperative patients after total hip arthroplasty

  Yuko Uesugi, Shinya Hayashi, Takaaki Fujishiro, Noriyuki Kanzaki, Takayuki Nishiyama

  May 2013, International Journal of Orthopaedic and Trauma Nursing, 17(2) (2), 91 - 98, English

  [Refereed]

  Scientific journal


• Evaluation of preoperative hip range of motion under general anaesthesia

  Takaaki Fujishiro, Shinya Hayashi, Noriyuki Kanzaki, Shingo Hashimoto, Masahiro Kurosaka, Taiki Kanno, Takeshi Masuda

  May 2013, HIP INTERNATIONAL, 23(3) (3), 298 - 302, English

  [Refereed]

  Scientific journal


• 変形性股関節症に対するChiari骨盤骨切り術の長期成績

  西山 隆之, Fujishiro Takaaki, Hayashi Shinya, 神崎 至幸, 橋本 慎吾, Kurosaka Masahiro

  Mar. 2013, 日本整形外科学会雑誌, 87(2号) (2号), S226, Japanese

  [Refereed]

  Research society


• 人工股関節置換術後でのエドキサバン投与の有用性と安全性

  橋本 慎吾, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, 神崎 至幸, 佐々木 宏, 柴沼 均, Kurosaka Masahiro

  Mar. 2013, 日本整形外科学会雑誌, 87(2号) (2号), S427, Japanese

  [Refereed]

  Research society


• Predicting leg-length change after total hip arthroplasty by measuring preoperative hip flexion under general anaesthesia

  Takaaki Fujishiro, Takayuki Nishiyama, Shinya Hayashi, Shingo Hashimoto, Masahiro Kurosaka, Taiki Kanno, Takeshi Masuda

  Dec. 2012, Journal of orthopaedic surgery (Hong Kong), 20(3) (3), 327 - 330, English

  Scientific journal


• Obese patients may have more soft tissue impingement following primary total hip arthroplasty

  Shinya Hayashi, Takayuki Nishiyama, Takaaki Fujishiro, Shingo Hashimoto, Noriyuki Kanzaki, Kotaro Nishida, Masahiro Kurosaka

  Dec. 2012, INTERNATIONAL ORTHOPAEDICS, 36(12) (12), 2419 - 2423, English

  [Refereed]

  Scientific journal


• Akt phosphorylation in human chondrocytes is regulated by p53R2 in response to mechanical stress

  K. Kawakita, T. Nishiyama, T. Fujishiro, S. Hayashi, N. Kanzaki, S. Hashimoto, K. Takebe, K. Iwasa, S. Sakata, K. Nishida, R. Kuroda, M. Kurosaka

  Dec. 2012, OSTEOARTHRITIS AND CARTILAGE, 20(12) (12), 1603 - 1609, English

  [Refereed]

  Scientific journal


• Long-term results of intertrochanteric varus osteotomy for the dysplastic hip

  Takayuki Nishiyama, Yasuhiro Saegusa, Takaaki Fujishiro, Shinya Hayashi, Noriyuki Kanzaki, Shingo Hashimoto, Masahiro Kurosaka

  Nov. 2012, HIP INTERNATIONAL, 22(6) (6), 628 - 632, English

  [Refereed]

  Scientific journal


• 【骨・関節のバイオメカニクス-最近の進歩】 人工股関節動作解析を目的としたイメージマッチングと骨盤座標系の自動決定法

  Nishiyama Takayuki, Hayashi Shinya, Fujishiro Takaaki, Kurosaka Masahiro

  金原出版, Oct. 2012, 整形・災害外科, 55(11号) (11号), 1355 - 1364, Japanese

  [Refereed]

  Scientific journal


• 軟骨細胞におけるAktのリン酸化はメカニカルストレスで生じるp53R2により制御される

  Nishiyama Takayuki, Fujishiro Takaaki, Hayashi Shinya, Kurosaka Masahiro

  Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1219, Japanese

  [Refereed]

  Research society


• 関節リウマチ滑膜細胞におけるDcR3による遺伝子発現誘導の検討

  Miura Yasushi, Hayashi Shinya, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1110 - S1110, Japanese

  [Refereed]

  Research society


• ヒト軟骨細胞においてPTENはtype II collagenの発現を制御する

  Nishiyama Takayuki, Hayashi Shinya, Fujishiro Takaaki, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1332, Japanese

  [Refereed]

  Research society


• Periprosthetic bone mineral density with a cementless triple tapered stem is dependent on daily activity

  Shinya Hayashi, Takayuki Nishiyama, Takaaki Fujishiro, Noriyuki Kanzaki, Shingo Hashimoto, Masahiro Kurosaka

  Jun. 2012, INTERNATIONAL ORTHOPAEDICS, 36(6) (6), 1137 - 1142, English

  [Refereed]

  Scientific journal


• Leg Length Change in Total Hip Arthroplasty With Subtrochanteric Femoral Shortening Osteotomy for Crowe Type IV Developmental Hip Dysplasia

  Takaaki Fujishiro, Takayuki Nishiyama, Shinya Hayashi, Masahiro Kurosaka, Taiki Kanno, Takeshi Masuda

  Jun. 2012, JOURNAL OF ARTHROPLASTY, 27(6) (6), 1019 - 1022, English

  [Refereed]

  Scientific journal


• 両側THA後、両側恥骨・腸骨にinsufficiency fractureを呈した1例

  Nishiyama Takayuki, Fujishiro Takaaki, Hayashi Shinya, Kurosaka Masahiro

  May 2012, 中部日本整形外科災害外科学会雑誌, 55(3号) (3号), 669 - 670, Japanese

  Research society


• 人工股関節全置換術後患者はいつまで杖を使用するべきか 体幹加速度リサージュ波形用いた歩行解析

  Nishiyama Takayuki, Fujishiro Takaaki, Hayashi Shinya, Miura Yasushi

  Apr. 2012, 理学療法学, 39(Suppl.2) (Suppl.2), 0912, Japanese

  [Refereed]

  Research society


• Kerboull型プレートを用いた人工股関節再置換術の術後成績

  Nishiyama Takayuki, Fujishiro Takaaki, Hayashi Shinya, Kurosaka Masahiro

  Mar. 2012, 日本整形外科学会雑誌, 86(3号) (3号), S353, Japanese

  [Refereed]

  Research society


• Bilateral insufficiency fracture of the pelvis following THA: A case report

  Shinya Hayashi, Takayuki Nishiyama, Takaaki Fujishiro, Shingo Hashimoto, Masahiro Kurosaka

  Hindawi Limited, 2012, Case Reports in Medicine, 2012, 170736, English

  [Refereed]

  Scientific journal


• A Case of Acute Prosthesis Migration after Femoral Head Replacement due to Osteomalacia by FGF23-Induced Tumor.

  Shinya Hayashi, Takayuki Nishiyama, Takaaki Fujishiro, Shingo Hashimoto, Noriyuki Kanzaki, Teruya Kawamoto, Toshihiro Akisue, Kotaro Nishida, Masahiro Kurosaka

  Fibroblast growth factor 23 (FGF23) was recently identified as an important factor involved in the development of hypophosphatemic rickets and osteomalacia. We experienced a rare case of acute prosthesis migration after hemihip arthroplasty due to FGF23-induced tumor. The patient underwent femoral head replacement because of femoral neck fracture, but prosthesis migration was occurred at 1 week after operation. The patient took various examinations, and FGF23-induced tumor was found in his right wrist. The tumor was resected, and he underwent total hip arthroplasty 8 month later. Finally, he was able to obtain free gait without pain.

  2012, Case reports in medicine, 2012, 503956 - 503956, English, International magazine

  [Refereed]

  Research institution


• 人工骨頭置換術後感染に伴う後腹膜膿瘍の1例

  Nishiyama Takayuki, Fujishiro Takaaki, Hayashi Shinya, Kurosaka Masahiro

  Jan. 2012, 日本骨・関節感染症学会雑誌, 25, 96 - 99, Japanese

  [Refereed]

  Scientific journal


• Predicting leg-length change after total hip arthroplasty by measuring preoperative hip flexion under general anaesthesia

  Takaaki Fujishiro, Takayuki Nishiyama, Shinya Hayashi, Shingo Hashimoto, Masahiro Kurosaka, Taiki Kanno, Takeshi Masuda

  2012, JOURNAL OF ORTHOPAEDIC SURGERY, 20(3) (3), 327 - 330, English

  [Refereed]

  Scientific journal


• 両手同時撮像用架台と心臓用コイル用いた手部造影MRIのRA診断への有用性の検討

  三浦 靖史, 福田 康治, 前田 俊恒, 立石 耕司, 林 申也, 藤井 正彦, 杉村 和朗, 黒坂 昌弘

  (一社)日本関節病学会, Oct. 2011, 日本関節病学会誌, 30(3) (3), 414 - 414, Japanese

  [Refereed]


• PLGF repairs myocardial ischemia through mechanisms of angiogenesis, cardioprotection and recruitment of myo-angiogenic competent marrow progenitors

  Hiroto Iwasaki, Atsuhiko Kawamoto, Marc Tjwa, Miki Horii, Saeko Hayashi, Akira Oyamada, Tomoyuki Matsumoto, Shigefumi Suehiro, Peter Carmeliet, Takayuki Asahara

  Sep. 2011, PLoS ONE, 6(9) (9), e24872, English

  [Refereed]

  Scientific journal


• DcR3-TL1A signalling inhibits cytokine-induced proliferation of rheumatoid synovial fibroblasts

  Masayasu Takahashi, Yasushi Miura, Shinya Hayashi, Koji Tateishi, Koji Fukuda, Masahiro Kurosaka

  Sep. 2011, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 28(3) (3), 423 - 427, English

  [Refereed]

  Scientific journal


• 関節リウマチ滑膜細胞におけるTL1AとDcR3の発現に関する検討

  福田 康治, 三浦 靖史, 高橋 完靖, 林 申也, 立石 耕司, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1297 - S1297, Japanese

  [Refereed]


• DcR3 induces cell proliferation through MAPK signaling in chondrocytes of osteoarthritis

  S. Hayashi, T. Nishiyama, Y. Miura, T. Fujishiro, N. Kanzaki, S. Hashimoto, T. Matsumoto, M. Kurosaka, R. Kuroda

  Jul. 2011, OSTEOARTHRITIS AND CARTILAGE, 19(7) (7), 903 - 910, English

  [Refereed]

  Scientific journal


• 関節リウマチの関節外病変 Fスケールを用いた関節リウマチ患者の胃食道逆流症(GERD)に関する検討

  三浦 靖史, 福田 康治, 高橋 完靖, 林 申也, 黒坂 昌弘

  (一社)日本リウマチ学会, Jun. 2011, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 55回・20回, 426 - 426, Japanese

  [Refereed]


• DcR3はTL1Aを介してサイトカインによるリウマチ滑膜細胞の増殖を抑制する

  高橋 完靖, 三浦 靖史, 福田 康治, 林 申也, 立石 耕司, 黒坂 昌弘

  (一社)日本リウマチ学会, Jun. 2011, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 55回・20回, 490 - 490, Japanese

  [Refereed]


• 関節リウマチ滑膜細胞におけるTL1AとDcR3の発現に関する検討

  福田 康治, 三浦 靖史, 高橋 完靖, 林 申也, 立石 耕司, 黒坂 昌弘

  (一社)日本リウマチ学会, Jun. 2011, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 55回・20回, 491 - 491, Japanese

  [Refereed]


• 分子レベルからみた整形外科疾患(シリーズVIII) DcR3と関節リウマチ

  高橋 完靖, 三浦 靖史, 林 申也, 福田 康治, 立石 耕司, 黒坂 昌弘

  金原出版(株), May 2011, 整形・災害外科, 54(6) (6), 672 - 673, Japanese

  [Refereed]


• Maintenance of periprosthetic bone mineral density with a cementless three dimensional straight tapered stem

  Shinya Hayashi, Takayuki Nishiyama, Takaaki Fujishiro, Noriyuki Kanzaki, Shingo Hashimoto, Ken Takebe, Masahiro Kurosaka

  Mar. 2011, HIP International, 21(2) (2), 163 - 167, English

  [Refereed]

  Scientific journal


• 両手同時撮影コイルを用いたMRIによる関節リウマチ滑膜炎の定量化の検討

  三浦 靖史, 立石 耕司, 高橋 完靖, 福田 康治, 林 申也, 藤井 正彦, 杉村 和朗, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2011, 日本整形外科学会雑誌, 85(3) (3), S746 - S746, Japanese

  [Refereed]


• Regulation of p38 MAPK phosphorylation inhibits chondrocyte apoptosis in response to heat stress or mechanical stress

  Ken Takebe, Takayuki Nishiyama, Shinya Hayashi, Shingo Hashimoto, Takaaki Fujishiro, Noriyuki Kanzaki, Kohei Kawakita, Kenjiro Iwasa, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2011, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 27(3) (3), 329 - 335, English

  [Refereed]

  Scientific journal


• Avulsion-fracture of the anterior superior iliac spine with meralgia paresthetica: a case report.

  Shinya Hayashi, Takayuki Nishiyama, Takaaki Fujishiro, Noriyuki Kanzaki, Masahiro Kurosaka

  2011, Journal of orthopaedic surgery (Hong Kong), 19(3) (3), 384 - 385, English

  Scientific journal


• Osteoarthritis of the talonavicular joint with pseudarthrosis of the navicular bone: A case report

  Noriyuki Kanzaki, Takayuki Nishiyama, Takaaki Fujishiro, Shinya Hayashi, Yoshiyuki Takakura, Yoshinori Takakura, Masahiro Kurosaka

  2011, Journal of Medical Case Reports, 5, English

  [Refereed]

  Scientific journal


• Evaluation of intra-pelvic screw position prior to revision total hip arthroplasty - a report of 2 cases

  Shinya Hayashi, Takayuki Nishiyama, Takaaki Fujishiro, Noriyuki Kanzaki, Shinsuke Kihara, Masahiro Kurosaka

  Jan. 2011, HIP INTERNATIONAL, 21(1) (1), 125 - 127, English

  [Refereed]

  Scientific journal


• Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing

  Tomoyuki Matsumoto, Masaaki Ii, Hiromi Nishimura, Taro Shoji, Yutaka Mifune, Atsuhiko Kawamoto, Ryosuke Kuroda, Tomoaki Fukui, Yohei Kawakami, Tomoya Kuroda, Sang Mo Kwon, Hiroto Iwasaki, Miki Horii, Ayumi Yokoyama, Akira Oyamada, Sang Yang Lee, Shinya Hayashi, Masahiro Kurosaka, Satoshi Takaki, Takayuki Asahara

  Sep. 2010, JOURNAL OF EXPERIMENTAL MEDICINE, 207(10) (10), 2207 - 2223, English

  [Refereed]

  Scientific journal


• Retroperitoneal abscess following infected bipolar hemiarthroplasty diagnosed by metallosis: A case report

  Takaaki Fujishiro, Shinya Hayashi, Noriyuki Kanzaki, Shinya Oka, Masahiro Kurosaka, Takayuki Nishiyama

  Jul. 2010, HIP International, 20(3) (3), 338 - 339, English

  [Refereed]

  Scientific journal


• Decoy receptor 3 is highly expressed in patients with rheumatoid arthritis

  Shinya Hayashi, Yasushi Miura, Koji Tateishi, Masayasu Takahashi, Masahiro Kurosaka

  Feb. 2010, Modern Rheumatology, 20(1) (1), 63 - 68, English

  [Refereed]

  Scientific journal


• DcR3 protects THP-1 macrophages from apoptosis by increasing integrin α4

  Koji Tateishi, Yasushi Miura, Shinya Hayashi, Masayasu Takahashi, Masahiro Kurosaka

  Nov. 2009, Biochemical and Biophysical Research Communications, 389(4) (4), 593 - 598, English

  [Refereed]

  Scientific journal


• SIRT1 Regulation of Apoptosis of Human Chondrocytes

  Koji Takayama, Kazunari Ishida, Takehiko Matsushita, Norifumi Fujita, Shinya Hayashi, Ken Sasaki, Katsumasa Tei, Seiji Kubo, Tomoyuki Matsumoto, Hiroyuki Fujioka, Masahiro Kurosaka, Ryosuke Kuroda

  Sep. 2009, ARTHRITIS AND RHEUMATISM, 60(9) (9), 2731 - 2740, English

  [Refereed]

  Scientific journal


• Role of p53 in Human Chondrocyte Apoptosis in Response to Shear Strain

  Shingo Hashimoto, Takayuki Nishiyama, Shinya Hayashi, Takaaki Fujishiro, Ken Takebe, Noriyuki Kanzaki, Ryosuke Kuroda, Masahiro Kurosaka

  Aug. 2009, ARTHRITIS AND RHEUMATISM, 60(8) (8), 2340 - 2349, English

  [Refereed]

  Scientific journal


• Infusion Time of Infliximab Can Be Reduced to 1 Hour in Patients with Rheumatoid Arthritis

  MIURA Yasushi

  Objective: With the proper safety procedures, we investigated the possibility of reducing the infusion time of infliximab (INFX) in patients with rheumatoid arthritis (RA) to 1 hour to decrease the burden of infusion on patients.
  Methods: In patients with RA treated at least 5 times with 2-hour infusion of INFX without adverse infusion reactions, the infusion time was reduced to 90 min. Only in patients successfully treated with 90-min infusion of INFX without infusion reactions at least twice was the infusion time further reduced to 1 hour.
  Results: Thirty patients (26 females & 4 males, mean age: 49.1±15.6 years, history of RA: 8.2±8.8 years) were treated with 2-hour INFX infusion. Five of the 30 showed various infusion reactions, whereas 25 of the 30 were treated successfully without infusion reactions 12.4±6.5 times. Twenty-two of the 25 patients were subsequently treated with 90-min infusion 3.4±2.5 times and only 1 patient showed a mild infusion reaction. Seventeen of the 21 were then treated with 1-hour infusion 6.1±4.1 times and only 1 patient showed a very mild infusion reaction. The infusion reaction occurring when the infusion time was reduced to 90 min was treated with the administration of antihistamine and acetaminophen, and the infusion of INFX was completed with a decreased 2-hour infusion rate. In the case of the patient who had an infusion reaction associated with the 1-hour infusion, the reaction was very mild and it was successfully treated immediately by simply slowing down the infusion rate to 2 hours.
  Conclusion: The infusion time of INFX can be safely reduced by up to 1 hour without severe adverse effects in patients with RA who have been successfully treated at least 5 times with a 2-hour INFX infusion rate without infusion reactions.

  Japanese Society for Joint Diseases, 2009, Japanese Journal of Joint Diseases, 28(4) (4), 515 - 519, English


• Effect of etidronate on COX-2 expression and PGE(2) production in macrophage-like RAW 264.7 cells stimulated by titanium particles

  Yoshihiro Suzuki, Takayuki Nishiyama, Keiichiro Hasuda, Takaaki Fujishiro, Takahiro Niikura, Shinya Hayashi, Shingo Hashimoto, Masahiro Kurosaka

  Nov. 2007, JOURNAL OF ORTHOPAEDIC SCIENCE, 12(6) (6), 568 - 577, English

  [Refereed]

  Scientific journal


• Synchrotron radiation coronary microangiography for morphometric and physiological evaluation of myocardial neovascularization induced by endothelial progenitor cell transplantation

  Hiroto Iwasaki, Kazuhito Fukushima, Atsuhiko Kawamoto, Keiji Umetani, Akira Oyamada, Saeko Hayashi, Tomoyuki Matsumoto, Masakazu Ishikawa, Toshihiko Shibata, Hiromi Nishimura, Hidekazu Hirai, Yutaka Mifune, Miki Horii, Kazuro Sugimura, Shigefumi Suehiro, Takayuki Asahara

  Jun. 2007, Arteriosclerosis, Thrombosis, and Vascular Biology, 27(6) (6), 1326 - 1333, English

  [Refereed]

  Scientific journal


• Decoy receptor 3 expressed in rheumatoid synovial fibroblasts protects the cells against fas-induced apoptosis

  Shinya Hayashi, Yasushi Miura, Takayuki Nishiyama, Makoto Mitani, Koji Tateishi, Yoshitada Sakai, Akira Hashiramoto, Masahiro Kurosaka, Shunichi Shiozawa, Minoru Doita

  Apr. 2007, Arthritis and Rheumatism, 56(4) (4), 1067 - 1075, English

  [Refereed]

  Scientific journal


• Therapeutic potential of vasculogenesis and osteogenesis promoted by peripheral blood CD34-positive cells for functional bone healing

  Tomoyuki Matsumoto, Atsuhiko Kawamoto, Ryosuke Kuroda, Masakazu Ishikawa, Yutaka Mifune, Hiroto Iwasaki, Masahiko Miwa, Miki Horii, Saeko Hayashi, Akira Oyamada, Hiromi Nishimura, Satoshi Murasawa, Minoru Doita, Masahiro Kurosaka, Takayuki Asahara

  Oct. 2006, AMERICAN JOURNAL OF PATHOLOGY, 169(4) (4), 1440 - 1457, English

  [Refereed]

  Scientific journal


• Angiopoietin-1 acts onto alpha 5 beta 1 integrin (VLA-5) to activate MAP kinases in rheumatoid synovial cells.

  Matsuda Shinichi, Miura Yasushi, Hayashi Shinya, Yoshida Kosuke, Hashiramoto Akira, Kurosaka Masahiro, Shiozawa Shunichi

  Sep. 2006, ARTHRITIS AND RHEUMATISM, 54(9) (9), S812

  [Refereed]


• 関節リウマチの臨床 リウマチ性疾患患者の不安と抑鬱状態の評価

  MIURA, Yasushi, NISHIYAMA, Takayuki, HASHIRAMOTO, Akira, SHIOZAWA, Shunichi, KUROSAKA, Masahiko, SAURA,Ryuichi

  Mar. 2006, 日本リウマチ学会総会・学術集会抄録集, pp.176-176, Japanese

  International conference proceedings


• 関節リウマチの治療 メトトレキサートとレフルノミド 当科におけるレフルノミドの使用成績と,中止後の治療方法の検討

  MIURA, Yasushi, NISHIYAMA, Takayuki, HASHIRAMOTO, Akira, SHIOZAWA, Shunichi, SAURA,Ryuichi, KUROSAKA, Masahiko

  Mar. 2006, 日本リウマチ学会総会・学術集会抄録集, pp.106-106, Japanese

  International conference proceedings


• 滑膜増殖と制御 関節リウマチ滑膜細胞におけるdecoy receptor 3の機能解析

  MIURA, Yasushi, NISHIYAMA, Takayuki, HASHIRAMOTO, Akira, SAURA,Ryuichi, SHIOZAWA, Shunichi, KUROSAKA, Masahiko

  Mar. 2006, 日本リウマチ学会総会・学術集会抄録集, pp.194-194, Japanese

  International conference proceedings


• 関節リウマチ滑膜細胞発現Death Receptor 3(DR3)の機能解析

  三浦 靖史, 柱本 照, 清水 真希子, 酒井 千菜, 西山 隆之, 三谷 誠, 林 申也, 石川 斉, 黒坂 昌弘, 塩沢 和子, 居村 茂明, 塩沢 俊一

  (一社)日本リウマチ学会, Apr. 2005, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 49回・14回, 233 - 233, Japanese


• 関節リウマチ滑膜細胞におけるDcR3発現の解析

  林 申也, 三浦 靖史, 西山 隆之, 三谷 誠, 佐浦 隆一, 柱本 照, 塩沢 俊一, 吉矢 晋一, 黒坂 昌弘

  (一社)日本リウマチ学会, Apr. 2005, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 49回・14回, 234 - 234, Japanese


• Acquired pseudarthrosis of the radius and ulna in a neurofibromatosis patient with radiographic normal bone: A case report

  Shinya Hayashi, Daisuke Kobayashi, Shinichi Satsuma, Shinichi Yoshiya, Masahiro Kurosaka

  Jan. 2005, Journal of Hand Surgery, 30(1) (1), 168 - 171, English

  [Refereed]

  Scientific journal


• 上腕動脈の血栓除去術を必要とした小児上腕骨顆上骨折の1例

  FUJIOKA, Hiroyuki, MAKINO, Takeshi, TERUKINA,Mitsunobu, KUROSAKA, Masahiko

  Jan. 2005, 日本肘関節学会雑誌, 12巻, 1号, pp. S56-S56, Japanese

  International conference proceedings


• [Morphological basis of periodontal nerve endings].

  Maeda T, Hayashi S

  Aug. 2000, Kaibogaku zasshi. Journal of anatomy, 75(4) (4), 377 - 380

  [Refereed]


• Anti-inflammatory actions of new antihistamines

  S. Hayashi, S. Hashimoto

  1999, Clinical and Experimental Allergy, 29(12) (12), 1593 - 1596, English

  [Refereed]

  Scientific journal

• D2TRAに対するJAK阻害薬治療による低疾患活動性達成に関連する因子の解析

  林申也, 中野直樹, 壺坂正徳, 亀長智幸, 生田健明, 和田健佑, 栖田慶仁, 齋藤亮, 前田琢磨, 積山賢, 前田俊恒, 松原司, 黒田良祐

  2023, 日本臨床リウマチ学会プログラム・抄録集, 38th


• D2TRAに対するJAK阻害薬の有効性に関するX線学的評価の比較~トファシチニブ対バリシチニブ~

  壺坂正徳, 林申也, 中野直樹, 亀長智幸, 亀長智幸, 生田健明, 和田健佑, 栖田慶仁, 栖田慶仁, 齋藤亮, 前田琢磨, 松本知之, 積山賢, 山田啓貴, 三枝淳, 松原司, 黒田良祐

  2023, 日本臨床リウマチ学会プログラム・抄録集, 38th


• D2T RA患者に対するバリシチニブの有効性に関してのX線学的検討~non-D2T RA患者との比較~

  和田健佑, 林申也, 齋藤亮, 前田琢磨, 栖田慶仁, 尾ノ井勇磨, 立花章太郎, 安喰健祐, 生田健明, 亀長智幸, 壺坂正徳, 黒田雄一, 中野直樹, 松本知之, 積山賢, 山田啓貴, 三枝淳, 松原司, 黒田良祐

  2023, 日本臨床リウマチ学会プログラム・抄録集, 38th


• D2T RA患者とnon-D2T RA患者のBaricitinib導入初期の疾患活動性の比較

  生田健明, 林申也, 中野直樹, 黒田雄一, 亀長智幸, 壺坂正徳, 安喰健祐, 尾ノ井勇磨, 立花章太郎, 栖田慶仁, 和田健佑, 齋藤亮, 前田琢磨, 積山賢, 前田俊恒, 松本知之, 山田啓貴, 三枝淳, 松原司, 黒田良祐

  2023, 日本臨床リウマチ学会プログラム・抄録集, 38th


• D2T RA患者に対するJAK阻害薬(TOF,BAR)の有効性に関してのX線学的検討~non-D2T RA患者との比較~

  齋藤亮, 林申也, 前田琢磨, 栖田慶仁, 栖田慶仁, 和田健佑, 尾ノ井勇磨, 立花章太郎, 安喰健祐, 生田健明, 壺坂正徳, 亀長智幸, 亀長智幸, 黒田雄一, 中野直樹, 松本知之, 積山賢, 山田啓貴, 三枝淳, 松原司, 黒田良祐

  2023, 日本臨床リウマチ学会プログラム・抄録集, 38th


• D2T RA患者のb/tsDMARDs導入初期の疾患活動性の特徴~non-D2T RA患者との比較~

  栖田慶仁, 栖田慶仁, 亀長智幸, 亀長智幸, 林申也, 齋藤亮, 前田琢磨, 和田健佑, 尾ノ井勇磨, 立花章太郎, 安喰健祐, 生田健明, 壺坂正徳, 黒田雄一, 前田俊恒, 中野直樹, 松本知之, 積山賢, 山田啓貴, 三枝淳, 黒田良祐, 松原司

  2023, 日本臨床リウマチ学会プログラム・抄録集, 38th


• D2TRAに対するトファシチニブとバリシチニブの臨床成績

  中野直樹, 林申也, 壺坂正徳, 亀長智幸, 生田健明, 和田健佑, 栖田慶仁, 齋藤亮, 前田琢磨, 黒田雄一, 松本知之, 積山賢, 山田啓貴, 三枝淳, 松原司, 黒田良祐

  2023, 日本臨床リウマチ学会プログラム・抄録集, 38th


• D2T RA患者に対するJAC阻害薬(Tofacitinib)の治療効果について

  前田琢磨, 亀長智幸, 亀長智幸, 林申也, 齋藤亮, 栖田慶仁, 栖田慶仁, 和田健佑, 尾ノ井勇磨, 立花章太郎, 安喰健祐, 生田健明, 壺坂正徳, 黒田雄一, 前田俊恒, 中野直樹, 松本知之, 積山賢, 山田啓貴, 三枝淳, 松原司, 黒田良祐

  2023, 日本臨床リウマチ学会プログラム・抄録集, 38th


• 発育性股関節形成不全と無症候性股関節の放射線画像における骨形態の比較検討

  立花章太郎, 黒田雄一, 齊藤昌愛, 林申也, 藤田雅広, 菊池健一, 生田健明, 安喰健祐, 尾ノ井勇磨, 黒田良祐

  2023, 日本整形外科学会雑誌, 97(2) (2)


• 発育性股関節形成不全と無症候性股関節の放射線画像における骨形態の比較検討

  立花章太郎, 林申也, 黒田雄一, 齊藤昌愛, 藤田雅広, 菊池健一, 生田健明, 安喰健祐, 尾ノ井勇磨, 黒田良祐

  2022, 日本股関節学会学術集会プログラム・抄録集, 49th


• Pelvic morphology medial to the femoral head center predicts anterior coverage and range of motion after curved periacetabular osteotomy.

  Tomoyuki Kamenaga, Shinya Hayashi, Shingo Hashimoto, Koji Fukuda, Koji Takayama, Masanori Tsubosaka, Yoshinori Takashima, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  This study observed anterior coverage extent after lateral rotation of the acetabulum, without anterior or posterior rotation, during curved periacetabular osteotomy by three-dimensional simulation, and determined if preoperative pelvic morphology affects postoperative anterior coverage and range of motion. Thirty patients scheduled for consecutive primary curved periacetabular osteotomy for developmental hip dysplasia at our hospital between 2016 and 2017 were included. Virtual acetabular osteotomies were performed to achieve a postoperative lateral center-edge angle of 30°. We measured anterior center-edge angles before curved periacetabular osteotomy through the medial one-third and one-quarter of the femoral head as an index reflecting the pelvic morphology medial to the femoral head center. The range of motion simulation was performed after virtual curved periacetabular osteotomy. Single linear regression analysis was performed to examine correlations between preoperative pelvic morphology parameters and anterior center-edge angles after virtual osteotomy. Furthermore, linear regression analysis was used to assess correlations between center-edge angles and simulated range of motions (P < .05). Anterior center-edge angle after virtual osteotomy was more strongly correlated with the anterior center-edge angle through the medial one-third (r = .92, P < .0001) and one-quarter (r = .84, P < .0001) of the femoral head. Flexion angle and internal rotation at 90° flexion showed significant correlations with anterior center-edge angle through the medial one-third (r = -.62, P = .0003; r = -.57, P = .001) and one-quarter (r = -.60, P = .0005; r = -.55, P = .002) of the femoral head and anterior center-edge angle after virtual osteotomy (r = -.67, P = .0005; r = -.62, P = .0003). Measuring preoperative parameters reflecting pelvic morphology enables surgeons to predict postoperative anterior coverage and range of motion in curved periacetabular osteotomy cases.

  08 Feb. 2020, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 38(9) (9), 2031 - 2039, English, International magazine


• 多剤耐性因子MDR1発現に対するJAK阻害薬の影響の検討

  菊池健一, 福田康治, 林申也, 亀長智幸, 高島良典, 藤田雅広, 黒田良祐, 橋本麿和, 前田俊恒, 舟橋恵子, 舟橋恵子, 松原司, 松原司

  2020, 日本リウマチ学会総会・学術集会プログラム・抄録集, 64th (CD-ROM)


• 関節リウマチの高齢発症に関与する遺伝子の探索

  橋本麿和, 舟橋恵子, 舟橋恵子, 前田俊恒, 高島良典, 亀長智幸, 福田康治, 林申也, 佐川昭, 松野博明, 泉原智麿, 生野英祐, 片山耕, 土田豊実, 岩橋充啓, 都留智巳, 織部元廣, 松原司, 松原司

  2020, 日本リウマチ学会総会・学術集会プログラム・抄録集, 64th (CD-ROM)


• 脂肪由来幹細胞の難治性骨折に対する治癒促進効果

  亀長 智幸, 松本 知之, 高山 孝治, 林 申也, 橋本 慎吾, 福田 康治, 黒田 雄一, 壺坂 正徳, 高島 良典, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1753 - S1753, Japanese


• 巨細胞性動脈炎におけるMMP-9の役割

  前田 俊恒, 渡部 龍, 福田 康治, 林 申也, 三浦 靖史, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1829 - S1829, Japanese


• エイコサペンタエン酸含有ゼラチンハイドロゲルは変形性関節症進行を抑制する

  壺坂 正徳, 林 申也, 木原 伸介, 永田 純平, 高島 良典, 亀長 智幸, 高山 孝治, 橋本 慎吾, 松本 知之, 田畑 泰彦, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1954 - S1954, Japanese


• 関節リウマチ患者に対するイグラチモドの治療継続率

  福田康治, 福田康治, 松原司, 松原司, 舟橋惠子, 舟橋惠子, 橋本麿和, 林申也, 亀長智幸, 高島良典, 酒井良忠, 黒田良祐

  2019, 日本臨床リウマチ学会プログラム・抄録集, 34th


• 【骨粗鬆症診療の真の目的は何か?!-脆弱性骨折の予防と診療の最前線】 脆弱性骨折の連鎖 ケーススタディから学ぶ

  Niikura Takahiro, 岩倉崇, Ooe Keisuke, Hayashi Shinya, 福井友章, 西本華子, Kuroda Ryosuke

  (株)ライフメディコム, Oct. 2018, カレントテラピー, 36(10号) (10号), 970 - 979, Japanese

  [Refereed]

  Introduction scientific journal


• Bik Plays an Important Role of Cell Proliferation Caused By Nitric Oxide in Rheumatoid Arthritis Synovium

  Takeshi Ueha, Yoshitada Sakai, Kohjin Suzuki, Koji Fukuda, Toshihisa Maeda, Hanako Nishimoto, Shinya Hayashi, Yasushi Miura, Ryosuke Kuroda, Akira Hashiramoto

  Oct. 2017, ARTHRITIS & RHEUMATOLOGY, 69, English

  Summary international conference


• Decoy Receptor 3 up-Regulates Cadherin 2 in Rheumatoid Synovial Fibroblasts

  Koji Fukuda, Yasushi Miura, Shinya Hayashi, Toshihisa Maeda, Ryosuke Kuroda

  Oct. 2017, ARTHRITIS & RHEUMATOLOGY, 69, English

  Summary international conference


• 【FAI(大腿骨寛骨臼インピンジメント)の最新知見】 FAIに関する基礎的研究の最新知見

  橋本慎吾, 鎮西伸顕, 鎮西伸顯, Hayashi Shinya, 黒田良佑, Kuroda Ryosuke

  Feb. 2017, 関節外科, 36(2号) (2号), 124 - 130, Japanese

  [Invited]

  Introduction scientific journal


• EVALUATION OF BONE METABOLISM AND QOL IN PATIENTS WITH OSTEOPOROSIS AFTER TREATMENT WITH THE ANTI-RANKL ANTIBODY DENOSUMAB

  T. Maeda, S. Hayashi, Y. Miura, Y. Sakai, R. Kuroda

  Nov. 2016, OSTEOPOROSIS INTERNATIONAL, 27, S784 - S784, English

  Summary international conference


• AICAR INDUCED MITOCHONDRIAL APOPTOSIS AND INHIBITED CELL PROLIFERATION AND MMP-3/RANKL SECRETION VIA ENHANCEMENT OF MITOCHONDRIAL BIOGENESIS IN RHEUMATOID ARTHRITIS FIBROBLAST-LIKE SYNOVIAL CELLS

  T. Ueha, Y. Sakai, T. Maeda, M. Morishita, K. Fukuda, S. Hayashi, H. Nishimoto, Y. Miura, R. Kuroda, A. Hashiramoto, M. Kurosaka

  Jun. 2016, ANNALS OF THE RHEUMATIC DISEASES, 75, 922 - 922, English

  Summary international conference


• 【復帰を早めるスポーツ損傷低侵襲手術テクニック】 ＜下肢＞股関節唇損傷に対する関節鏡視下手術

  橋本慎吾, Hayashi Shinya

  May 2016, Orthopaedics, 29(5号) (5号), 25 - 33, Japanese

  Introduction other


• P21 DEFICIENCY IS SUSCEPTIBLE TO OSTEOARTHRITIS WITH INFLAMMATION

  S. Kihara, S. Hayashi, N. Kanzaki, S. Hashimoto, N. Chinzei, M. Haneda, K. Takeuchi, R. Kuroda, M. Kurosaka

  Apr. 2016, OSTEOARTHRITIS AND CARTILAGE, 24, S386 - S387, English

  Summary international conference


• EVALUATION OF BONE METABOLISM MARKERS AND QOL IN PATIENTS WITH OSTEOPOROSIS AFTER TREATMENT WITH THE ANTI-RANKL ANTIBODY DENOSUMAB

  T. Maeda, S. Hayashi, Y. Miura, Y. Sakai, R. Kuroda, M. Kurosaka

  Apr. 2016, OSTEOPOROSIS INTERNATIONAL, 27, S126 - S127, English

  Summary international conference


• 【足関節・足部疾患の最新治療】 疾患各論 足関節症 変形性足関節症 人工足関節全置換術 変形性足関節症・関節リウマチに対する人工足関節全置換術

  Kanzaki Noriyuki, 高倉義典, 林申也, 橋本慎吾, Kuroda Ryosuke, 黒坂昌弘

  Apr. 2016, 別冊整形外科, (69号) (69号), 147 - 151, Japanese

  [Invited]

  Introduction commerce magazine


• Changeable neck

  島 直子, 西山 隆之, 林 申也

  金原出版, Jan. 2016, 整形・災害外科, 59(1) (1), 35 - 42, Japanese


• P21 DEFICIENCY WAS SUSCEPTIBLE TO OSTEOARTHRITIS WITH INFLAMMATION

  S. Kihara, S. Hayashi, N. Kanzaki, S. Hashimoto, S. Sakata, N. Chinzei, M. Haneda, K. Fukuda, T. Maeda, T. Fujishiro, Y. Miura, R. Kuroda, M. Kurosaka

  Jun. 2015, ANNALS OF THE RHEUMATIC DISEASES, 74, 167 - 167, English

  Summary international conference


• 人工足関節置換術において術前可動域は術後可動域に影響を与えるか

  Kanzaki Noriyuki, 高倉義典, 高倉義幸, 杜多昭彦, 藤代高明, Hayashi Shinya, 橋本慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2015, 日本整形外科学会雑誌, 89(3号) (3号), S695, Japanese

  [Refereed]

  Meeting report


• Centrosomal Protein 70kDa Is Down-Regulated By Decoy Receptor 3 in Specifically Rheumatoid Synovial Fibroblasts.

  Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Masahiro Kurosaka

  Oct. 2014, ARTHRITIS & RHEUMATOLOGY, 66, S1073 - S1073, English

  Summary international conference


• 関節リウマチ患者に対する人工股関節全置換術後在院日数予測モデルの逸脱要因 : ディシジョンツリー分析を用いた検討

  中村 瑠美, 山口 良太, 丸山 孝樹, 藤代 高明, 林 申也, 神崎 至幸, 橋本 慎吾, 酒井 良忠

  日本RAのリハビリ研究会, Jun. 2014, 日本RAのリハビリ研究会誌, 28(1) (1), 46 - 48, Japanese


• 距骨に骨軟骨腫を生じた一例

  木原 伸介, Kanzaki Noriyuki, 秋末 敏宏, Hayashi Shinya, 鎮西 伸顕, 酒井 良忠, Kuroda Ryosuke, Kurosaka Masahiro

  May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S308, Japanese

  [Refereed]

  Meeting report


• REMOTE ASSESSMENTS AND INSTRUCTIONS FOR HOME-REHABILITATION VIA CUSTOM-MADE WEBSITE IN PATIENTS WITH HIP AND KNEE OSTEOARTHRITIS, A PRELIMINARY REPORT

  Y. Uesugi, C. Nishii, C. Yamada, S. Hayashi, R. Kuroda, S. Hashimoto, T. Matsumoto, T. Matsushita, T. Nishii, T. Fujishiro

  Apr. 2014, OSTEOARTHRITIS AND CARTILAGE, 22, S432 - S433, English

  Summary international conference


• 【最新関節リウマチ学-寛解・治癒を目指した研究と最新治療-】 関節リウマチの発症要因と発症メカニズム 発症メカニズム DcR3による遺伝子発現誘導

  Hayashi Shinya, 三浦 靖史, Kurosaka Masahiro

  Apr. 2014, 日本臨床, 72(増刊3 最新関節リウマチ学) (増刊3 最新関節リウマチ学), 68 - 72, Japanese

  [Invited]

  Introduction scientific journal


• FAIの分子生物学的特徴

  CHINSEI NOBUAKI, HASHIMOTO SHINGO, FUJISHIRO TAKAAKI, HAYASHI SHIN'YA, KANZAKI NORIYUKI, SAKATA SHUHEI, KIHARA SHINSUKE, HANEDA KATSUHIKO, UCHIDA SOJI, KUROSAKA MASAHIRO

  2014, 日本股関節学会学術集会プログラム・抄録集, 41st, 250, Japanese


• Decoy Receptor 3 Regulates the Expression of Tryptophan Hydroxylase TPH1 in Rheumatoid Synovial Fibroblasts

  Toshihisa Maeda, Yasushi Miura, Koji Fukuda, Shinya Hayashi, Masahiro Kurosaka

  Oct. 2013, ARTHRITIS AND RHEUMATISM, 65, S582 - S582, English

  Summary international conference


• DcR3は関節リウマチ滑膜線維芽細胞におけるトリプトファン水酸化酵素TPH1の発現を制御する

  前田 俊恒, 三浦 靖史, 福田 康治, Hayashi Shinya, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2013, 日本整形外科学会雑誌, 87(8) (8), S1416 - S1416, Japanese

  Meeting report


• DcR3による関節リウマチ滑膜細胞におけるIL-12Bp40発現誘導の検討

  福田 康治, 三浦 靖史, 前田 俊恒, Hayashi Shinya, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2013, 日本整形外科学会雑誌, 87(8) (8), S1423 - S1423, Japanese

  Meeting report


• PTEN REGULATES THE EXPRESSIONS OF TYPEII COLLAGEN AND AGGRECAN UNDER OXIDATIVE STRESS IN HUMAN CHONDROCYTES

  K. Iwasa, S. Hayashi, T. Fujishiro, K. Kawakita, N. Kanzaki, S. Hashimoto, N. Chinzei, S. Sakata, R. Kuroda, M. Kurosaka

  Apr. 2013, OSTEOARTHRITIS AND CARTILAGE, 21, S132 - S133, English

  Summary international conference


• OXIDATIVE STRESS INDUCED CHONDROCYTES APOPTOSIS WERE INHIBITED BY EICOSAPENTAENOIC ACID

  S. Sakata, S. Hayashi, T. Fujishiro, N. Kanzaki, S. Hashimoto, K. Kawakita, K. Iwasa, N. Chinzei, R. Kuroda, M. Kurosaka

  Apr. 2013, OSTEOARTHRITIS AND CARTILAGE, 21, S36 - S37, English

  Summary international conference


• P21 REGULATES MMP-13 EXPRESSION THROUGH STAT3 SIGNALING IN CHONDROCYTES

  S. Hayashi, T. Nishiyama, S. Hashimoto, T. Fujishiro, N. Kanzaki, K. Iwasa, S. Sakata, N. Chinzei, R. Kuroda, M. Kurosaka

  Apr. 2013, OSTEOARTHRITIS AND CARTILAGE, 21, S46 - S47, English

  Summary international conference


• 関節リウマチの病因・病態 関節リウマチ滑膜細胞におけるDcR3によるIL-12B p40発現誘導の検討

  福田 康治, 三浦 靖史, 前田 俊恒, Hayashi Shinya, Kurosaka Masahiro

  (一社)日本リウマチ学会, Mar. 2013, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集57回・22回, 57回・22回, 327 - 327, Japanese

  Meeting report


• 関節リウマチの治療 生物学的製剤(TNF阻害薬) インフリキシマブ時間短縮投与の忍容性 6年間の経験

  三浦 靖史, 福田 康治, 前田 俊恒, Hayashi Shinya, 柴沼 均, 立石 博臣, Kurosaka Masahiro

  (一社)日本リウマチ学会, Mar. 2013, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集57回・22回, 57回・22回, 418 - 418, Japanese

  [Refereed]

  Meeting report


• リハビリテーション 楽器を用いたリウマチ患者に対する音楽療法に関する検討

  三浦 靖史, 松尾 絹絵, 福田 康治, 前田 俊恒, Hayashi Shinya, Kurosaka Masahiro, 山崎 郁子

  (一社)日本リウマチ学会, Mar. 2013, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集57回・22回, 57回・22回, 442 - 442, Japanese

  [Refereed]

  Meeting report


• DcR3は関節リウマチ滑膜線維芽細胞においてトリプトファン水酸化酵素TPH1の発現を制御する

  前田 俊恒, 三浦 靖史, 福田 康治, Hayashi Shinya, Kurosaka Masahiro

  (一社)日本リウマチ学会, Mar. 2013, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集57回・22回, 57回・22回, 556 - 556, Japanese

  Meeting report


• 関節リウマチ滑膜線維芽細胞におけるトリプトファン水酸化酵素TPH1発現の検討

  Miura Yasushi, Hayashi Shinya, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1367 - S1367, Japanese

  [Refereed]

  Meeting report


• THE EXPRESSIONS OF TYPEII COLLAGEN IS REGULATED BY PTEN IN HUMAN CHODROCYTES.

  K. Iwasa, T. Nishiyama, S. Hayashi, T. Fujishiro, S. Hashimoto, K. Kawakita, S. Sakata, R. Kuroda, M. Kurosaka

  Apr. 2012, OSTEOARTHRITIS AND CARTILAGE, 20, S149 - S150, English

  Summary international conference


• 関節リウマチ滑膜線維芽細胞におけるトリプトファン水酸化酵素発現の検討

  Miura Yasushi, Hayashi Shinya, Kurosaka Masahiro

  (一社)日本リウマチ学会, Mar. 2012, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集56回・21回, 56回・21回, 550 - 550, Japanese

  [Refereed]

  Meeting report


• 関節リウマチの病因・病態(1) 関節リウマチ滑膜細胞におけるDcR3による遺伝子発現誘導の検討

  Miura Yasushi, Hayashi Shinya, Kurosaka Masahiro

  (一社)日本リウマチ学会, Mar. 2012, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集56回・21回, 56回・21回, 338 - 338, Japanese

  [Refereed]

  Meeting report


• 関節リウマチの関節外病変(1) 関節リウマチ患者の胃食道逆流症(GERD)に関する検討

  Miura Yasushi, Hayashi Shinya, Kurosaka Masahiro

  (一社)日本リウマチ学会, Mar. 2012, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集56回・21回, 56回・21回, 403 - 403, Japanese

  [Refereed]

  Meeting report


• Operative treatment of avulsion fracture of the anterior superior iliac spine with meralgia paresthetica : report of a case

  西田 京平, 西山 隆之, 林 申也

  南江堂, Dec. 2011, 整形外科, 62(13) (13), 1388 - 1390, Japanese


• MECHANICAL STRESS INCREASED P21(CIP1)EXPRESSION IN CHONDROCYTES

  S. Hayashi, T. Nishiyama, R. Kuroda, M. Kurosaka

  Sep. 2011, OSTEOARTHRITIS AND CARTILAGE, 19, S108 - S108, English

  Summary international conference


• THE EXPRESSION OF TYPE2 COLLAGEN IS REGULATED BY PTEN IN CHONDROCYTES

  K. Iwasa, T. Nishiyama, S. Hayashi, T. Fujishiro, N. Kanzaki, K. Takebe, K. Kawakita, R. Kuroda, M. Kurosaka

  Sep. 2011, OSTEOARTHRITIS AND CARTILAGE, 19, S114 - S114, English

  Summary international conference


• Osteoarthritis of Talonavicular Joint on Pseudarthrosis of the Navicular Bone : A Case Report

  KANZAKI Noriyuki, NISHIYAMA Takayuki, FUJISIRO Takaaki, HAYASHI Shinya, TAKEBE Ken, KAWAKITA Kouhei, IWASA Kenjiro, KUROSAKA Masahiro

  31 May 2011, 日本足の外科学会雑誌 = The journal of the Japanese Society for Surgery of the Foot, 32(2) (2), 194 - 197, Japanese


• INVOLVEMENT OF P38 MAP KINASE PHOSPHORYLATION IN CHONDROCYTES APOPTOSIS INDUCED BY HEAT STRESS

  K. Takebe, T. Nishiyama, S. Hayashi, T. Fujishiro, N. Kanzaki, K. Kawakita, K. Iwasa, R. Kuroda, M. Kurosaka

  Oct. 2010, OSTEOARTHRITIS AND CARTILAGE, 18, S123 - S124, English

  Summary international conference


• Expression of DcR3 in bone and soft tissue tumors

  Masaya Imabori, Toshihiro Akisue, Kenta Kishimoto, Hitomi Hara, Shinichiro Kishimoto, Yoshiyuki Okada, Naomasa Fukase, Shinya Hayashi, Teruya Kawamoto, Masahiro Kurosaka

  2009, Cancer Therapy, 7(ISSUE A) (ISSUE A), 43 - 48

  [Refereed]


• リウマチ滑膜線維芽細胞に対するDcR3の直接的作用の検討

  高橋完靖, 三浦靖史, 立石耕司, 林申也, 酒井良忠, 塩沢俊一, 黒坂昌弘

  2008, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 52nd-17th, 348, Japanese


• 関節リウマチ患者に対するインフリキシマブ時間短縮投与の試み

  三浦靖史, 酒井良忠, 立石耕司, 高橋完靖, 林申也, 柱本照, 塩沢俊一, 黒坂昌弘

  2008, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 52nd-17th, 360, Japanese


• マクロファージ系細胞におけるデコイレセプターDcR3の機能解析

  立石耕司, 三浦靖史, 林申也, 高橋完靖, 酒井良忠, 塩沢俊一, 黒坂昌弘

  2008, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 52nd-17th, 315, Japanese


• Angiopoietin‐1は滑膜細胞上のVLA‐5(α5β1インテグリン)を介してシグナル伝達する

  松田真一, 三浦靖史, 林申也, 吉田幸祐, 柱本照, 黒坂昌弘, 塩沢俊一

  2007, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 51st-16th, 263, Japanese


• 関節リウマチ患者における血清中DcR3濃度の解析‐健常者との比較

  林申也, 三浦靖史, 西山隆之, 立石耕司, 酒井良忠, 塩沢俊一, 黒坂昌弘

  2007, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 51st-16th, 378, Japanese


• 関節リウマチ滑膜線維芽細胞におけるDEC‐205の発現

  大沼健一郎, 三浦靖史, 三浦靖史, 三浦靖史, 林申也, 黒坂昌弘, 塩沢俊一

  2007, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 51st-16th, 317, Japanese


• マクロファージ系細胞株U937におけるアポトーシス関連分子DcR3発現の検討

  立石耕司, 三浦靖史, 林申也, 酒井良忠, 塩沢俊一, 黒坂昌弘

  2007, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 51st-16th, 378, Japanese


• Death receptor 3 is specially expressed in rheumatoid synovium and TL1A, a physiological ligand for DR3, efficiently induces apoptosis in rheumatoid synovial fibroblasts

  Y Miura, A Hashiramoto, M Shimizu, H Inoue, S Hayashi, K Shiozawa, S Shiozawa

  Jul. 2005, ANNALS OF THE RHEUMATIC DISEASES, 64, 128 - 128, English

  Summary international conference

• 最新関節リウマチ学-寛解・治療を目指した研究と最新治療- / DcR3による遺伝子発現誘導

  Hayashi Shinya, 三浦靖史, Kurosaka Masahiro

  Joint work, 日本臨床社, Apr. 2014, Japanese

  Scholarly book

• 脱臼性股関節症に対するロボット支援THAのソケット設置精度検証

  林申也, 橋本慎吾, 黒田雄一, 中野直樹, 松本知之, 石田一成, 柴沼均, 黒田良祐

  第47回日本股関節学会学術集会

  Oral presentation


• 寛骨臼回転骨切り術において臼蓋傾斜の過度な補正は術後可動域に強く影響する

  林 申也, 橋本 慎吾, 髙山 孝治, 松本 知之, 黒田 良祐

  第93回日本整形外科学会学術集会

  Poster presentation


• HA カラードショートステムの術後ステム周囲骨反応変化とステムアライメントとの 関係

  林申也, 橋本慎吾, 髙山孝治, 松本知之, 黒田良祐

  第50回日本人工関節学会, Feb. 2020, Japanese

  Oral presentation


• HAカラードショートステムの術後ステム周囲骨反応変化-他のステムと比較して

  林申也

  第46回日本股関節学会学術集会, Oct. 2019, Japanese

  [Invited]

  Invited oral presentation


• 寛骨臼回転骨切り術において臼蓋傾斜の補正は前方被覆及び術後可動域に強く影響する

  林申也, 橋本慎吾, 髙山孝治, 松本知之, 高島良典, 壺坂正徳, 亀長智幸, 黒田良祐

  第46回日本股関節学会学術集会, Oct. 2019, Japanese

  Oral presentation


• Postoperative Excessive Anterior Acetabular Coverage Is Associated With Decrease in Range of Motion After Periacetabular Osteotomy

  Shinya Hayashi, Shingo Hashimoto, Koji Takayama, Tomoyuki Matsumoto, Ryosuke Kuroda

  The 32nd International Society for Technology in Arthroplasty, Oct. 2019, English

  Oral presentation


• RA患者における関節破壊の特徴によるトシリズマブ有効性の検討

  林申也, 松原司, 福田康治, 舟橋恵子, 橋本磨和, 亀長智幸, 高島良典, 黒田良祐

  第63回リウマチ学会総会・学術集会, Apr. 2019, Japanese

  Poster presentation


• 骨膜パッチを用いない自家培養軟骨細胞移植 ー治験の経験からー

  KURODA RYOSUKE, MATSUMOTO TOMOYUKI, HAYASHI SHINYA, MATSUSHITA TAKEHIKO

  第32回日本軟骨代謝学会, Mar. 2019, Japanese, 日本軟骨代謝学会, 大阪, Domestic conference

  Nominated symposium


• サイクリンディペンデントキナーゼインヒビター１欠損マウスは炎症の増悪を伴い変形性関節症が進行する

  木原 伸介, HAYASHI SHINYA, HASHIMOTO SHINGO, KANZAKI NORIYUKI, TAKAYAMA KOUJI, MATSUMOTO TOMOYUKI, 鎮西 伸顕, 岩佐 賢二郎, 羽田 勝彦, 竹内 一裕, NISHIDA KOTARO, KURODA RYOSUKE

  第32回日本軟骨代謝学会, Mar. 2019, Japanese, 日本軟骨代謝学会, 大阪, Domestic conference

  [Invited]

  Invited oral presentation


• Postoperative excessive anterior acetabular coverage is associated with decrease in range of motion after periacetabular osteotomy

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Kouji Takayama, Nao Shibanuma, Ryosuke Kuroda

  AAOS annual meeting 2019, Mar. 2019, English, American Academy of Orthopaedic Surgeons, Las Vegas, International conference

  Poster presentation


• 単顆型人工膝関節置換術の術後患者満足度に影響を及ぼす因子の検討

  TAKAYAMA KOUJI, MATSUMOTO TOMOYUKI, 石田 一成, HAYASHI SHINYA, HASHIMOTO SHINGO, KURODA RYOSUKE

  第49回日本人工関節学会, Feb. 2019, Japanese, 日本人工関節学会, 東京, Domestic conference

  Poster presentation


• 前外側アプローチでの人工股関節全置換術における腸骨大腿靱帯および恥骨大腿靱帯温存の試み

  藤田 雅広, 藤代 高明, 西田 亮太, 尾ノ井 勇磨, 高瀬 恭平, 飛田 祐一, 岡本 剛治, 平中 崇文, HASHIMOTO SHINGO, HAYASHI SHINYA, KURODA RYOSUKE

  第49回日本人工関節学会, Feb. 2019, Japanese, 日本人工関節学会, 東京, Domestic conference

  Oral presentation


• 仰臥位THAの術中の骨盤安定性に影響する因子の検討

  亀長 智幸, HAYASHI SHINYA, HASHIMOTO SHINGO, 高島 良典, 壺坂 正徳, 黒田 雄一, TAKAYAMA KOUJI, MATSUMOTO TOMOYUKI, KURODA RYOSUKE

  第49回日本人工関節学会, Feb. 2019, Japanese, 日本人工関節学会, 東京, Domestic conference

  Oral presentation


• 仰臥位THAにおけるポータブルナビゲーションの精度評価とラーニングカーブ

  藤代 高明, 平中 崇文, 岡本 剛治, 飛田 祐一, HASHIMOTO SHINGO, HAYASHI SHINYA, KURODA RYOSUKE

  第49回日本人工関節学会, Feb. 2019, Japanese, 日本人工関節学会, 東京, Domestic conference

  Oral presentation


• セメントレストリプルテーパー型カーブドショートステム周囲の術後2年の骨密度変化

  高瀬 恭平, 藤代 高明, 西田 亮太, 尾ノ井 勇磨, 藤田 雅広, 飛田 祐一, 岡本 剛治, 平中 崇文, HASHIMOTO SHINGO, HAYASHI SHINYA, KURODA RYOSUKE

  第49回日本人工関節学会, Feb. 2019, Japanese, 日本人工関節学会, 東京, Domestic conference

  Oral presentation


• TriLock stem使用症例の中期成績

  壺坂 正徳, HAYASHI SHINYA, HASHIMOTO SHINGO, 高島 良典, 亀長 智幸, 黒田 雄一, 竹内 一裕, TAKAYAMA KOUJI, MATSUMOTO TOMOYUKI, KURODA RYOSUKE

  第49回日本人工関節学会, Feb. 2019, Japanese, 日本人工関節学会, 東京, Domestic conference

  Oral presentation


• TKA後10年の下肢alignment変化とその変化に関連する因子の検討

  黒田 雄一, MATSUMOTO TOMOYUKI, TAKAYAMA KOUJI, HAYASHI SHINYA, HASHIMOTO SHINGO, 竹内 一裕, 壺坂 正徳, 亀長 智幸, 高島 良典, KURODA RYOSUKE

  第49回日本人工関節学会, Feb. 2019, Japanese, 日本人工関節学会, 東京, Domestic conference

  Oral presentation


• Therapeutic effects of adipose derived regenerative cells for fracture healing using rat unhealing fracture model.

  Tomoyuki Kamenaga, Tomoyuki Matsumoto, Shinya Hayashi, Yoshinori Takashima, Masanori Tsubosaka, Yuichi Kuroda, Kazuhiro Takeuchi, Koji Fukuda, Koji Takayama, Shingo Hashimoto, Ryosuke Kuroda

  The 65th Annual Meeting of Orthopaedic Research Society, Feb. 2019, English, Orthopaedic Research Society, Austin, International conference

  Poster presentation


• The Influence of Gelatin Hydrogel Including EicosapentaenoicAcid on the Osteoarthritis Progression in Vivo

  Masanori Tsubosaka, Shinya Hayashi, Shinsuke Kihara, Yoshinori Takashima, Tomoyuki Kamenaga, Yuichi Kuroda, Kazuhiro Takeuchi, Koji Takayama, Shingo Hashimoto, Tomoyuki Matsumoto, Yasuhiko Tabata, Ryosuke Kuroda

  The 65th Annual Meeting of Orthopaedic Research Society, Feb. 2019, English, Orthopaedic Research Society, Austin, International conference

  Poster presentation


• Robotic-arm assisted THAの初期精度評価

  HAYASHI SHINYA, 柴沼 均, HASHIMOTO SHINGO, TAKAYAMA KOUJI, MATSUMOTO TOMOYUKI, KURODA RYOSUKE

  第49回日本人工関節学会, Feb. 2019, Japanese, 日本人工関節学会, 東京, Domestic conference

  Oral presentation


• POLARステム使用THAにおける術前計画と使用サイズの差異

  HASHIMOTO SHINGO, HAYASHI SHINYA, TAKAYAMA KOUJI, MATSUMOTO TOMOYUKI, KURODA RYOSUKE

  第49回日本人工関節学会, Feb. 2019, Japanese, 日本人工関節学会, 東京, Domestic conference

  Oral presentation


• Influence of Adipose-derived Regenerative Cells for the Treatment of Osteoarthritis of the Knee

  Masanori Tsubosaka, Tomoyuki Matsumoto, Yusuke Harada, Yoshinori Takashima, Tomoyuki Kamenaga, Takahiro Yamashita, Yuichi Kuroda, Kazuhiro Takeuchi, Koji Takayama, Hashimoto Shingo, Shinya Hayashi, Takehiko Matsushita, Hideki Iwaguro, Satoshi Sobajima, Ryosuke Kuroda

  The 65th Annual Meeting of Orthopaedic Research Society, Feb. 2019, English, Orthopaedic Research Society, Austin, International conference

  Poster presentation


• Anthologyステムを用いた人工股関節全置換術の短期成績

  高島 良典, HASHIMOTO SHINGO, 亀長 智幸, 壺坂 正徳, 黒田 雄一, TAKAYAMA KOUJI, HAYASHI SHINYA, MATSUMOTO TOMOYUKI, KURODA RYOSUKE

  第49回日本人工関節学会, Feb. 2019, Japanese, 日本人工関節学会, 東京, Domestic conference

  Oral presentation


• Anthology Hip SystemのHAコーティング有無での検討

  竹内 一裕, HASHIMOTO SHINGO, MATSUMOTO TOMOYUKI, HAYASHI SHINYA, TAKAYAMA KOUJI, 黒田 雄一, 壺坂 正徳, 亀長 智幸, 高島 良典, KURODA RYOSUKE

  第49回日本人工関節学会, Feb. 2019, Japanese, 日本人工関節学会, 東京, Domestic conference

  Oral presentation


• 関節リウマチ患者に対する追跡期間10年を超えるTNF阻害薬の治療継続率

  福田 康治, 松原 司, 舟橋 恵子, 奥田 康介, 堤 聡, 冨田 大介, HAYASHI SHINYA, MIURA YASUSHI, SAKAI YOSHITADA, KURODA RYOSUKE

  第33回日本臨床リウマチ学会, Nov. 2018, Japanese, 日本臨床リウマチ学会, 東京, Domestic conference

  Oral presentation


• 関節リウマチにおける、周術期感染症対策

  HAYASHI SHINYA

  第66回神戸整形外科セミナー, Nov. 2018, Japanese, 神戸整形外科セミナー, 神戸, Domestic conference

  [Invited]

  Invited oral presentation


• 簡易ナビゲーションシステムを用いたキネマティックアライメントTKAにおける脛骨骨切り精度と術後臨床成績の検討

  壺坂 正徳, MATSUMOTO TOMOYUKI, TAKAYAMA KOUJI, 高島 良典, 亀長 智幸, 黒田 雄一, 竹内 一裕, HASHIMOTO SHINGO, HAYASHI SHINYA, KURODA RYOSUKE

  第46回日本関節病学会, Nov. 2018, Japanese, 日本関節病学会, 岡山, Domestic conference

  Oral presentation


• いかに評価するか：臨床所見から

  MATSUMOTO TOMOYUKI, TAKAYAMA KOUJI, 村津 裕嗣, 石田 一成, 中野 直樹, 亀長 智幸, HASHIMOTO SHINGO, HAYASHI SHINYA, KURODA RYOSUKE

  日本臨床バイオメカニクス学会, Nov. 2018, Japanese, 日本臨床バイオメカニクス学会, 秋田, Domestic conference

  Public symposium


• TKA後深部感染に対する治療戦略

  MATSUMOTO TOMOYUKI, TAKAYAMA KOUJI, 石田 一成, 壺坂 正徳, 中野 直樹, HASHIMOTO SHINGO, HAYASHI SHINYA, KURODA RYOSUKE

  第46回日本関節病学会, Nov. 2018, Japanese, 日本関節病学会, 岡山, Domestic conference

  Public symposium


• PS型TKAにおける術中軟部組織バランスが膝関節キネマティクスと術後屈曲角度に及ぼす影響

  亀長 智幸, MATSUMOTO TOMOYUKI, TAKAYAMA KOUJI, HAYASHI SHINYA, HASHIMOTO SHINGO, 黒田 雄一, 壺坂 正徳, 高島 良典, KURODA RYOSUKE

  日本臨床バイオメカニクス学会, Nov. 2018, Japanese, 日本臨床バイオメカニクス学会, 秋田, Domestic conference

  Oral presentation


• 軟骨細胞においてNF-κBを介してのAQP9の抑制による異化因子の減弱

  竹内 一裕, HAYASHI SHINYA, MATSUMOTO TOMOYUKI, HASHIMOTO SHINGO, TAKAYAMA KOUJI, 黒田 雄一, 壺坂 正徳, NISHIDA KOTARO, KURODA RYOSUKE

  第33回日本整形外科学会基礎学術集会, Oct. 2018, Japanese, 日本整形外科学会, 奈良, Domestic conference

  Poster presentation


• 特発性大腿骨頭壊死症診療ガイドライン 保存治療

  上島 圭一郎, 石田 雅史, 齊藤 正純, 溝川 滋一, 大田 陽一, HAYASHI SHINYA

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Public symposium


• 特発性大腿骨頭壊死症患者における術前術後の性別によるQOLの特徴

  UESUGI YUKO, 坂井 孝司, 関 泰輔, HAYASHI SHINYA, 中村 順一, 稲葉 裕, 高橋 大介, 佐々木 幹, 中島 康晴, 間島 直彦, 加畑 加文, 須藤 啓広, 神野 哲也, 安藤 渉, 名越 智, 山本 謙吾, 仲宗根 哲, 山本 卓明, 菅野 伸彦

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Oral presentation


• 特発性大腿骨頭壊死症患者における術前後の経時的QOL評価

  坂井 孝司, UESUGI YUKO, 関 泰輔, HAYASHI SHINYA, 中村 順一, 稲葉 裕, 高橋 大介, 佐々木 幹, 中島 康晴, 間島 直彦, 加畑 加文, 須藤 啓広, 神野 哲也, 安藤 渉, 名越 智, 山本 謙吾, 仲宗根 哲, 山本 卓明, 菅野 伸彦

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Oral presentation


• 人工膝関節置換術後における深部感染74症例の治療成績：感染時期とメチシリン耐性菌感染の影響

  壺坂 正徳, MATSUMOTO TOMOYUKI, TAKAYAMA KOUJI, HAYASHI SHINYA, HASHIMOTO SHINGO, KURODA RYOSUKE

  第131回中部日本整形外科災害外科学会・学術集会, Oct. 2018, Japanese, 中部日本整形外科災害外科学会, 岡山, Domestic conference

  Poster presentation


• 人工股関節全置換術後における術式別の下肢筋力推移と歩行能力の関係性

  春名 勇祐, 中 雄太, 眞田 祐太朗, 古田土 雅都紀, 石田 一成, 柴沼 均, HASHIMOTO SHINGO, HAYASHI SHINYA

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Oral presentation


• 人工股関節全置換術における骨盤側方傾斜角と下肢筋力回復との関係性

  中 雄太, 春名 勇祐, 眞田 祐太朗, 古田土 雅都紀, 石田 一成, 柴沼 均, HASHIMOTO SHINGO, HAYASHI SHINYA

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Oral presentation


• 術前の股関節内局所麻酔注射の効果と股関節鏡術中所見や術後成績の予見性について

  鎮西 伸顕, HASHIMOTO SHINGO, HAYASHI SHINYA, TAKAYAMA KOUJI, MATSUMOTO TOMOYUKI, 三枝 康宏, KURODA RYOSUKE

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Oral presentation


• 手術加療に至った股関節唇損傷・FAI症例の特徴とは?

  HASHIMOTO SHINGO, HAYASHI SHINYA, TAKAYAMA KOUJI, MATSUMOTO TOMOYUKI, KURODA RYOSUKE

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Oral presentation


• 仰臥位THAの術中の骨盤安定性に影響する因子の検討

  亀長 智幸, HAYASHI SHINYA, HASHIMOTO SHINGO, MATSUMOTO TOMOYUKI, TAKAYAMA KOUJI, 藤代 高明, 平中 崇文, KURODA RYOSUKE

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Oral presentation


• 仰臥位THAにおけるポータブルナビゲーションの精度評価

  藤代 高明, 平中 崇文, 岡本 剛治, 飛田 祐一, HASHIMOTO SHINGO, HAYASHI SHINYA, KURODA RYOSUKE

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Oral presentation


• 仰臥位THAにおけるポータブルナビゲーションの精度に及ぼすBMIの影響

  亀長 智幸, HAYASHI SHINYA, HASHIMOTO SHINGO, TAKAYAMA KOUJI, MATSUMOTO TOMOYUKI, KURODA RYOSUKE

  第131回中部日本整形外科災害外科学会・学術集会, Oct. 2018, Japanese, 中部日本整形外科災害外科学会, 岡山, Domestic conference

  Oral presentation


• 関節リウマチ滑膜細胞におけるdecoy receptor 3によるcadherin 2発現誘導の検討

  福田 康治, MIURA YASUSHI, HAYASHI SHINYA, 前田 俊恒, KURODA RYOSUKE

  第33回日本整形外科学会基礎学術集会, Oct. 2018, Japanese, 日本整形外科学会, 奈良, Domestic conference

  Poster presentation


• 関節リウマチの生物製剤治療におけるSNPアルゴリズムの有用性

  亀長 智幸, 福田 康治, HAYASHI SHINYA, SAKAI YOSHITADA, 松原 司, KURODA RYOSUKE

  第131回中部日本整形外科災害外科学会・学術集会, Oct. 2018, Japanese, 中部日本整形外科災害外科学会, 岡山, Domestic conference

  Oral presentation


• 寛骨臼回転骨切り術後の可動域は移動骨片の前方被覆量に影響される

  HAYASHI SHINYA, HASHIMOTO SHINGO, TAKAYAMA KOUJI, MATSUMOTO TOMOYUKI, KURODA RYOSUKE

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Oral presentation


• セメントステムを使用した人工股関節全置換術後におけるステムアライメントとステム周囲の骨密度の関係

  古田土 雅都紀, 柴沼 均, HAYASHI SHINYA, 佐々木 宏, 石田 一成, HASHIMOTO SHINGO, 黒坂 昌弘, KURODA RYOSUKE

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Oral presentation


• TriLock stem使用症例の中期成績

  壺坂 正徳, HAYASHI SHINYA, HASHIMOTO SHINGO, 高島 良典, 亀長 智幸, 黒田 雄一, TAKAYAMA KOUJI, MATSUMOTO TOMOYUKI, KURODA RYOSUKE

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Oral presentation


• Trearment results of 74 deep infections after total knee arthroplasty : effects of infection timing and methicillin-resistant bacteria

  Masanori Tsubosaka, Tomoyuki Matsumoto, Kouji Takayama, Yuichi Kuroda, Kazuhiro Takeuchi, Shingo Hashimoto, Shinya Hayashi, Ryosuke Kuroda

  39th SICOT Orthopaedic World Congress, Oct. 2018, English, International Society of Orthopaedic Surgery and Traumatology, Montreal, International conference

  Poster presentation


• The predictive value of preoperative anesthetic hip joint injection for intra-articular pathology and hip arthroscopy outcomes

  Shingo Hashimoto, Shinya Hayashi, Kouji Takayama, Nobuaki Chinzei, Yuichi Kuroda, Tomoyuki Matsumoto, Ryosuke Kuroda

  Annual meeting of International Society for Hip Arthroscopy 2018, Oct. 2018, English, International Society for Hip Arthroscopy, Melbourne, International conference

  Poster presentation


• The influence of limb alignment and prosthetic orientation of patient-derived clinical outcome in total knee arthroplasty

  Yuichi Kuroda, Tomoyuki Matsumoto, Kouji Takayama, Masanori Tsubosaka, Kazuhiro Takeuchi, Shingo Hashimoto, Shinya Hayashi, Ryosuke Kuroda

  39th SICOT Orthopaedic World Congress, Oct. 2018, English, International Society of Orthopaedic Surgery and Traumatology, Montreal, International conference

  Poster presentation


• The Evaluation of lower limb alignment with HIP-TO-CALCANEUS rasiograph after unicompartmental knee arthroplasty

  Kouji Takayama, Tomoyuki Matsumoto, Kazunari Ishida, Masanori Tsubosaka, Yuichi Kuroda, Shingo Hashimoto, Shinya Hayashi, Ryosuke Kuroda

  39th SICOT Orthopaedic World Congress, Oct. 2018, English, International Society of Orthopaedic Surgery and Traumatology, Montreal, International conference

  Poster presentation


• S-ROM stemを用いた人工股関節置換術における合併症の検討

  岩佐 賢二郎, 西山 隆之, 織邊 隆, 熊谷 宏, 奥町 悦子, 木嶋 雄介, 佐竹 徹, HASHIMOTO SHINGO, HAYASHI SHINYA

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Oral presentation


• Spherical Periacetabular Osteotomy(SPO)の短期成績

  西山 隆之, 岩佐 賢二郎, 木嶋 雄介, 奥町 悦子, 佐竹 徹, 熊谷 宏, 織邊 隆, HASHIMOTO SHINGO, HAYASHI SHINYA

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Oral presentation


• Relationship of morphology of hip labral tear to the clinical findings before and after hip arthroscopy

  Nobuaki Chinzei, Shingo Hashimoto, Shinya Hayashi, Kouji Takayama, Yuchi Kuroda, Tomoyuki Matsumoto, Ryosuke Kuroda

  Annual meeting of International Society for Hip Arthroscopy 2018, Oct. 2018, English, International Society for Hip Arthroscopy, Melbourne, International conference

  Oral presentation


• Relationship between labral tear confirmed by hip arthroscopy and preoperative imaging finding

  Yuichi Kuroda, Shingo Hashimoto, Shinya Hayashi, Tomoyuki Matsumoto, Kouji Takayama, Kazuhiro Takeuchi, Masanori Tsubosaka, Tomoyuki Kamenaga, Yoshinori Takashima, Ryosuke Kuroda

  Annual meeting of International Society for Hip Arthroscopy 2018, Oct. 2018, English, International Society for Hip Arthroscopy, Melbourne, International conference

  Poster presentation


• Modified kinematically aligned total knee arthroplasty.

  Tomoyuki Matsumoto, Kouji Takayama, Masanori Tsubosaka, Kazunari Ishida, Yuichi Kuroda, Shingo Hashimoto, Shinya Hayashi, Ryosuke Kuroda

  The 62nd Annual Congress of the Korean Orthopaedic Association, Oct. 2018, English, The Korean Orthopaedic Association, Seoul, International conference

  [Invited]

  Nominated symposium


• Lessons learned from navigation- The Japanese experience

  Tomoyuki Matsumoto, Kouji Takayama, Kazunari ishida, Yuichi Kuroda, Masanori Tsubosaka, Naoki Nakano, Shingo Hashimoto, Shinya Hayashi, Ryosuke Kuroda

  39th SICOT Orthopaedic World Congress, Oct. 2018, English, International Society of Orthopaedic Surgery and Traumatology, Montreal, International conference

  [Invited]

  Nominated symposium


• Decoy Receptor 3 down-regulates Centrosomal Protein 70kDa in Specifically Rheumatoid Synovial Fibroblasts

  Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Ryosuke Kuroda

  第６回神緑会ヤングインベスティゲーターアワード, Oct. 2018, Japanese, 神緑会, 神戸, Domestic conference

  Poster presentation


• Anthologyステムを用いた人工股関節全置換術の短期成績

  高島 良典, HASHIMOTO SHINGO, MATSUMOTO TOMOYUKI, HAYASHI SHINYA, TAKAYAMA KOUJI, 竹内 一裕, 黒田 雄一, 壺坂 正徳, 亀長 智幸, KURODA RYOSUKE

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Oral presentation


• Anthology Hip SystemのHAコーティング有無での検討

  竹内 一裕, HASHIMOTO SHINGO, HAYASHI SHINYA, MATSUMOTO TOMOYUKI, TAKAYAMA KOUJI, 黒田 雄一, 壺坂 正徳, 亀長 智幸, 高島 良典, KURODA RYOSUKE

  第45回日本股関節学会学術集会, Oct. 2018, Japanese, 日本股関節学会学術集会, 名古屋, Domestic conference

  Oral presentation


• N-cadherin is up-regulated by Decoy Receptor 3 in Rheumatoid Synovial Fibroblasts

  Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Ryosuke Kuroda

  20th Asia Pacific League of Associations for Rheumatology Congress, Sep. 2018, English, Asia Pacific League of Associations for Rheumatology, Kaohsiung, International conference

  Poster presentation


• Denosumab treatment improves health related quality of life in patients with osteoporosis

  Shinya Hayashi, Kouji Fukuda, Toshihisa Maeda, Nobuaki Chinzei, Yuji Hiroshima, Shinsuke Kihara, Hanako Nishimoto, Yasushi Miura, Yoshitada Sakai, Shingo Hashimoto, Tomoyuki Matsumoto, Kouji Takayama, Takahiro Niikura, Kotaro Nishida, Ryosuke Kuroda

  ASBMR 2018 Annual Meeting, Sep. 2018, English, The American Society for Bone and Mineral Research, Montreal, International conference

  Poster presentation


• The influence of intraoperative soft tissue balance on clinical outcomes especially in patient satisfaction.

  Tomoyuki Matsumoto, Kouji Takayama, Hirotsugu Muratsu, Kazunari Ishida, Naoki Nakano, Yuichi Kuroda, Masanori Tsubosaka, Shingo Hashimoto, Shinya Hayashi, Ryosuke Kuroda

  第10回日本関節鏡・膝・スポーツ整形外科学会, Jun. 2018, English, 日本関節鏡・膝・スポーツ整形外科学会, 福岡, Domestic conference

  Nominated symposium


• Comparison of the retention rate of biological DMARDs ~ the data from patients with RA who were followed up for over 10 years

  Koji Fukuda, Tsukasa Matsubara, Keiko Funahashi, Tetsu Itami, Kosuke Okuda, Shinya Hayashi, Yoshitada Sakai, Ryosuke Kuroda

  Annual European Congress of Rheumalotogy - EULAR 2018, Jun. 2018, English, European League against Rheumatic Diseases, Amsterdam, International conference

  Poster presentation


• 骨盤骨切り術におけるnavigationの有効性

  HAYASHI SHINYA, HASHIMOTO SHINGO, TAKAYAMA KOUJI, MATSUMOTO TOMOYUKI, KURODA RYOSUKE

  第91回日本整形外科学会学術集会, May 2018, Japanese, 日本整形外科学会, 神戸, Domestic conference

  Poster presentation


• 生物学的製剤治療中のRA患者における単純ヘルペスおよび帯状疱疹ヘルペス発症に関わる遺伝子多型性の検討

  福田 康治, 松原 司, 児矢野 聡, 舟橋 恵子, 奥田 康介, HAYASHI SHINYA, SAKAI YOSHITADA, KURODA RYOSUKE, 佐川 昭, 松野 博明, 泉原 智磨, 生野 英祐

  第62回リウマチ学会総会・学術集会, Apr. 2018, Japanese, 日本リウマチ学会, 東京, Domestic conference

  Public symposium


• 生物学的製剤の治療継続率の比較-追跡期間10年を超える症例を対象とする-

  福田 康治, 松原 司, 舟橋 恵子, 児矢野 聡, 伊丹 哲, 奥田 康介, HAYASHI SHINYA, SAKAI YOSHITADA, KURODA RYOSUKE

  第62回リウマチ学会総会・学術集会, Apr. 2018, Japanese, 日本リウマチ学会, 東京, Domestic conference

  Poster presentation


• 関節リウマチ患者における関節破壊進行の予測はSNPｓ解析で可能である-多施設コホート研究-

  HAYASHI SHINYA, 松原 司, 児矢野 聡, 舟橋 恵子, 福田 康治, SAKAI YOSHITADA, KURODA RYOSUKE, 奥田 康介, 佐川 昭, 松野 博明, 泉原 智磨, 生野 英祐

  第62回リウマチ学会総会・学術集会, Apr. 2018, Japanese, 日本リウマチ学会, 東京, Domestic conference

  Public symposium


• 関節リウマチ滑膜細胞におけるCadherin 2の発現はDecoy receptor 3により誘導される

  福田 康治, MIURA YASUSHI, 前田 俊恒, HAYASHI SHINYA, KURODA RYOSUKE

  第62回リウマチ学会総会・学術集会, Apr. 2018, Japanese, 日本リウマチ学会, 東京, Domestic conference

  Public symposium


• ウサギ関節症モデルにおける脂肪由来再生幹細胞自家移植の治療効果についての検討

  黒田 雄一, MATSUMOTO TOMOYUKI, HAYASHI SHINYA, HASHIMOTO SHINGO, TAKAYAMA KOUJI, KURODA RYOSUKE

  第130回中部日本整形外科災害外科学会・学術集会, Apr. 2018, Japanese, 中部日本整形外科災害外科学会, 松山, Domestic conference

  Oral presentation


• RA患者においてデノスマブによる骨粗鬆症治療は患者QOLを改善する

  福田 康治, HAYASHI SHINYA, 寛島 佑史, 本田 久樹, 西本 華子, KURODA RYOSUKE

  第130回中部日本整形外科災害外科学会・学術集会, Apr. 2018, Japanese, 中部日本整形外科災害外科学会, 松山, Domestic conference

  Poster presentation


• Therapeutic effects of autologous adipose derived regenerative cells for osteoarthritis in an experimental rabbit model

  Yuichi Kuroda, Matsumoto Tomoyuki, Hayashi Shinya, Masanori Tsubosaka, Shinsuke Kirizuki, kazuhiro Takeuchi, Masahiko Haneda, Koji Takayama, Hashimoto Shingo, Kuroda Ryosuke

  The 64th Annual Meeting of the Orthopaedic Research Society, Mar. 2018, English, The Orthopaedic Research Society, New Orleans, USA, International conference

  Poster presentation


• The Influence of Gelatin Hydrogel Including Eicosapentaenoic Acid on the Osteoarthritis Progression in Vivo

  Masanori Tsubosaka, Hayashi Shinya, Shinsuke Kihara, Junpei Nagata, Yuichi Kuroda, Kazuhiro Takeuchi, Masahiko Haneda, Shinsuke Kirizuki, Koji Takayama, Hashimoto Shingo, Matsumoto Tomoyuki, Yasuhiko Tabata, Kuroda Ryosuke

  The 64th Annual Meeting of the Orthopaedic Research Society, Mar. 2018, English, The Orthopaedic Research Society, New Orleans, USA, International conference

  Oral presentation


• The effect of transcutaneous application of carbon dioxide on postoperative pain relief after total knee arthroplasty

  Koji Takayama, Matsumoto Tomoyuki, Hashimoto Shingo, Hayashi Shinya, Masanori Tsubosaka, Yuichi Kuroda, Kazuhiro Takeuchi, Masahiko Haneda, Takeshi Ueha, Sakai Yoshitada, Kuroda Ryosuke

  The 64th Annual Meeting of the Orthopaedic Research Society, Mar. 2018, English, The Orthopaedic Research Society, New Orleans, USA, International conference

  Poster presentation


• Intraoperative soft tissue balance/kinematics and clinical evaluation of kinematically versus mechanically aligned total knee arthroplasty

  Matsumoto Tomoyuki, Koji Takayama, Kazunari Ishida, Hayashi Shinya, Hashimoto Shingo, Masanori Tsubosaka, Yuichi Kuroda, Shinsuke Kirizuki, Kazuhiro Takeuchi, Masahiko Haneda, Hirotsugu Muratsu, Kuroda Ryosuke

  The 64th Annual Meeting of the Orthopaedic Research Society, Mar. 2018, English, The Orthopaedic Research Society, New Orleans, USA, International conference

  Oral presentation


• 単顆型人工膝関節置換術における脛骨implant orientation angleの検討

  Matsumoto Tomoyuki, 石田 一成, 羽田 勝彦, 桐月 伸輔, 竹内 一裕, 黒田 雄一, 壺坂 正德, Hashimoto Shingo, Hayashi Shinya, Kuroda Ryosuke

  The 48th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2018, Japanese, The Japanese Society for Replacement Arthroplasty, 東京, Domestic conference

  Oral presentation


• 人工膝関節全置換術後における深部感染74症例の治療成績 感染時期とメチシリン耐性菌感染の影響

  壺坂 正徳, Matsumoto Tomoyuki, 黒田 雄一, 竹内 一裕, 桐月 伸輔, 羽田 勝彦, Hashimoto Shingo, Hayashi Shinya, Kuroda Ryosuke

  The 48th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2018, Japanese, The Japanese Society for Replacement Arthroplasty, 東京, Domestic conference

  Oral presentation


• ステム前捻角を過度にコントロールすると術後大腿骨近位の骨密度が低下する

  Hayashi Shinya, Hashimoto Shingo, Matsumoto Tomoyuki, Kuroda Ryosuke

  The 48th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2018, Japanese, The Japanese Society for Replacement Arthroplasty, 東京, Domestic conference

  Poster presentation


• キネマティックアライメント法によるTKAの機種間による相違

  Matsumoto Tomoyuki, 石田 一成, 黒田 雄一, 壺坂 正德, 桐月 伸輔, 竹内 一裕, 羽田 勝彦, Hashimoto Shingo, Hayashi Shinya, 村津 裕嗣, Kuroda Ryosuke

  The 48th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2018, Japanese, The Japanese Society for Replacement Arthroplasty, 東京, Domestic conference

  Poster presentation


• UKAにおける脛骨後方傾斜角度の術中評価は正解か?

  石田 一成, 杜多 昭彦, Matsumoto Tomoyuki, 佐々木 宏, 古田土 雅都紀, 桐月 伸輔, Hayashi Shinya, Hashimoto Shingo, 黒坂 昌弘, Kuroda Ryosuke, 柴沼 均

  The 48th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2018, Japanese, The Japanese Society for Replacement Arthroplasty, 東京, Domestic conference

  Poster presentation


• Taper wedge型ステム2機種におけるレントゲン評価の比較

  竹内 一裕, Hashimoto Shingo, Hayashi Shinya, Matsumoto Tomoyuki, 羽田 勝彦, 黒田 雄一, 壺坂 正德, Kuroda Ryosuke

  The 48th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2018, Japanese, The Japanese Society for Replacement Arthroplasty, 東京, Domestic conference

  Oral presentation


• Revision THA後のADL・QOL・満足度に影響する術前因子についての検討

  黒田 雄一, Hayashi Shinya, Matsumoto Tomoyuki, Hashimoto Shingo, 羽田 勝彦, 桐月 伸輔, 竹内 一裕, 壺坂 正德, Kuroda Ryosuke

  The 48th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2018, Japanese, The Japanese Society for Replacement Arthroplasty, 東京, Domestic conference

  Oral presentation


• Bi-cruciate stablized TKAにおける術中kinematicsと患者立脚型評価

  桐月 伸輔, 石田 一成, 柴沼 均, Matsumoto Tomoyuki, 杜多 昭彦, 佐々木 宏, 古田土 雅都紀, 西澤 勇一郎, Hashimoto Shingo, Hayashi Shinya, Kuroda Ryosuke, 黒坂 昌弘

  The 48th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2018, Japanese, The Japanese Society for Replacement Arthroplasty, 東京, Domestic conference

  Poster presentation


• Anterolateral-supine approachによる人工股関節全置換術における白蓋カップ設置の正確性とリスク因子

  Hashimoto Shingo, Hayashi Shinya, Matsumoto Tomoyuki, Kuroda Ryosuke

  The 48th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2018, Japanese, The Japanese Society for Replacement Arthroplasty, 東京, Domestic conference

  Oral presentation


• キネマティックアライメント法によるTKAの術中軟部組織バランス・キネマティクス評価

  Matsumoto Tomoyuki, 石田 一成, 黒田 雄一, 壺坂 正德, 桐月 伸輔, 竹内 一裕, 羽田 勝彦, Hashimoto Shingo, Hayashi Shinya, 村津 裕嗣, Kuroda Ryosuke

  The45th Congress of the Japanese journal of joint diseases, Nov. 2017, Japanese, Japanese journal of joint diseases, 東京, Domestic conference

  Oral presentation


• キネマティックアライメント法によるTKAの術中軟部組織バランス・キネマティクス評価

  Matsumoto Tomoyuki, 石田 一成, 黒田 雄一, 壺坂 正德, 桐月 伸輔, 竹内 一裕, 羽田 勝彦, Hashimoto Shingo, Hayashi Shinya, 村津 裕嗣, Kuroda Ryosuke

  The44th Annual meeting of the Jpanese society for clinical biomechanics, Nov. 2017, Japanese, Japanese Society for Clinical Biomechanics, 松山, Domestic conference

  Oral presentation


• mobile-bearing TKA とfixed-bearing TKAの大腿脛骨間回旋角度と膝蓋大腿関節圧の比較検討

  黒田 雄一, Matsumoto Tomoyuki, Hayashi Shinya, Hashimoto Shingo, 羽田 勝彦, 桐月 伸輔, 竹内 一裕, 壺坂 正德, Kuroda Ryosuke

  The44th Annual meeting of the Jpanese society for clinical biomechanics, Nov. 2017, Japanese, Japanese Society for Clinical Biomechanics, 松山, Domestic conference

  Oral presentation


• HIP-to calcaneus radiographによる単顆型人工膝関節置換術術後下肢アライメント評価

  Matsumoto Tomoyuki, 石田 一成, Hashimoto Shingo, Hayashi Shinya, 壺坂 正德, 黒田 雄一, 竹内 一裕, 羽田 勝彦, 桐月 伸輔, Kuroda Ryosuke

  The45th Congress of the Japanese journal of joint diseases, Nov. 2017, Japanese, Japanese journal of joint diseases, 東京, Domestic conference

  Oral presentation


• 特発性大腿骨頭壊死症患者の就業の実態とQOLの特徴

  Uesugi Yuko, 坂井 孝司, 関 泰輔, Hayashi Shinya, 中村 順一, 稲葉 裕, 高橋 大介, 佐々木 幹, 本村 悟朗, 間島 直彦, 加畑 加文, 須藤 啓広, 神野 哲也, 安藤 渉, 名越 智, 山本 謙吾, 仲宗根 哲, 伊藤 浩, 山本 卓明, 菅野 伸彦

  The44th Annual meeting of Japanese hip society, Oct. 2017, Japanese, Japanese hip society, 東京, Domestic conference

  Oral presentation


• 特発性大腿骨頭壊死症患者の就業の実態とQOLの特徴

  UESUGI YUKO, 坂井 孝司, 関 泰輔, HAYASHI SHINYA, 中村 順一, 稲葉 裕, 髙橋 大介, 佐々木 幹, 本村 悟朗, 間島 直彦, 加畑 多文, 須藤 啓広, 神野 哲也, 安藤 渉, 名越 智, 山本 謙吾, 仲宗根 哲, 伊藤 浩, 山本 卓明, 菅野 伸彦

  第44回日本股関節学会, Oct. 2017, Japanese, Domestic conference

  Oral presentation


• 特発性大腿骨頭壊死症の病期・病型分類とQOLの関係

  坂井 孝司, Uesugi Yuko, 関 泰輔, Hayashi Shinya, 中村 順一, 稲葉 裕, 高橋 大介, 佐々木 幹, 本村 悟朗, 間島 直彦, 加畑 加文, 須藤 啓広, 神野 哲也, 安藤 渉, 名越 智, 山本 謙吾, 仲宗根 哲, 伊藤 浩, 山本 卓明, 菅野 伸彦

  The44th Annual meeting of Japanese hip society, Oct. 2017, Japanese, Japanese hip society, 東京, Domestic conference

  Oral presentation


• 特発性大腿骨頭壊死症の病期・病型分類とQOLの関係

  坂井 孝司, UESUGI YUKO, 関 泰輔, HAYASHI SHINYA, 中村 順一, 稲葉 裕, 髙橋 大介, 佐々木 幹, 本村 悟朗, 間島 直彦, 加畑 多文, 須藤 啓広, 神野 哲也, 安藤 渉, 名越 智, 山本 謙吾, 仲宗根 哲, 伊藤 浩, 山本 卓明, 菅野 伸彦

  第44回日本股関節学会, Oct. 2017, Japanese, Domestic conference

  Oral presentation


• 大腿骨髄腔形状とstem周囲の骨密度の変化および影響を与える因子

  羽田 勝彦, Hayashi Shinya, Matsumoto Tomoyuki, Hashimoto Shingo, 桐月 伸輔, 竹内 一裕, 黒田 雄一, 壺坂 正德, Kuroda Ryosuke

  The44th Annual meeting of Japanese hip society, Oct. 2017, Japanese, Japanese hip society, 東京, Domestic conference

  Poster presentation


• 前十字靱帯損傷後の遺残組織の形態の差異が治癒特性に与える影響

  桐月 伸輔, Matsumoto Tomoyuki, 黒田 雄一, 竹内 一裕, 羽田 勝彦, 井口 貴雄, Hashimoto Shingo, Hayashi Shinya, Matsushita Takehiko, Kuroda Ryosuke

  The 32nd Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2017, Japanese, The Japanese Orthopaedic Association, 沖縄, Domestic conference

  Poster presentation


• 正常ヒト関節軟骨細胞におけるAQP9の機能解析

  竹内 一裕, Hayashi Shinya, Matsumoto Tomoyuki, Hashimoto Shingo, 木原 伸介, 井口 貴雄, 桐月 伸輔, 羽田 勝彦, 黒田 雄一, Kuroda Ryosuke

  The 32nd Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2017, Japanese, The Japanese Orthopaedic Association, 沖縄, Domestic conference

  Oral presentation


• 人工股関節全置換術（THA)術後にポリエチレンライナーの脱転を認めた1例

  古田土 雅都紀, 柴沼 均, 石田 一成, 杜多 昭彦, 佐々木 宏, 黒坂 昌弘, Hayashi Shinya, Kuroda Ryosuke

  The44th Annual meeting of Japanese hip society, Oct. 2017, Japanese, Japanese hip society, 東京, Domestic conference

  Oral presentation


• 人工股関節全置換術における骨盤側方傾斜角とQOLの関係性

  中 雄太, 吉岡 芳泰, 石田 一成, 柴沼 均, Hashimoto Shingo, Hayashi Shinya

  The44th Annual meeting of Japanese hip society, Oct. 2017, Japanese, Japanese hip society, 東京, Domestic conference

  Oral presentation


• 術前評価から考える股関節唇縫合術の適応と手術手技

  Hashimoto Shingo, Hayashi Shinya, Matsumoto Tomoyuki, Kuroda Ryosuke

  The44th Annual meeting of Japanese hip society, Oct. 2017, Japanese, Japanese hip society, 東京, Domestic conference

  Public symposium


• 骨盤骨切り術におけるナビゲーション使用による精度評価

  Hayashi Shinya, Hashimoto Shingo, Matsumoto Tomoyuki, 柴沼 均, Kuroda Ryosuke

  The44th Annual meeting of Japanese hip society, Oct. 2017, Japanese, Japanese hip society, 東京, Domestic conference

  Oral presentation


• 寛骨臼側骨欠損に対しKTプレートと塊状同種骨を使用した人工股関節置換術の短期成績

  西山 隆之, 織邊 隆, 熊谷 宏, 齋藤 寧彦, 木嶋 雄介, Hashimoto Shingo, Hayashi Shinya

  The44th Annual meeting of Japanese hip society, Oct. 2017, Japanese, Japanese hip society, 東京, Domestic conference

  Oral presentation


• エクセターショートステムの使用経験

  柴沼 均, Hayashi Shinya, Hashimoto Shingo, 黒坂 昌弘

  The44th Annual meeting of Japanese hip society, Oct. 2017, Japanese, Japanese hip society, 東京, Domestic conference

  Oral presentation


• TKAにおける術後アライメントと患者立脚型臨床成績との関連性

  黒田 雄一, Matsumoto Tomoyuki, Hayashi Shinya, Hashimoto Shingo, Kuroda Ryosuke

  The 129ｔｈ Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Oct. 2017, Japanese, Meeting of The Central Japan Association of Orthopaedic Surgery, 富山, Domestic conference

  Oral presentation


• Taper wedge型ステム2機種におけるレントゲン評価の比較

  竹内 一裕, Hashimoto Shingo, Matsumoto Tomoyuki, Hayashi Shinya, 羽田 勝彦, 桐月 伸輔, 黒田 雄一, 壺坂 正德, Kuroda Ryosuke

  The44th Annual meeting of Japanese hip society, Oct. 2017, Japanese, Japanese hip society, 東京, Domestic conference

  Oral presentation


• Summit stem使用症例の中期成績

  壺坂 正徳, Hayashi Shinya, Hashimoto Shingo, 羽田 勝彦, 竹内 一裕, 黒田 雄一, Matsumoto Tomoyuki, Kuroda Ryosuke

  The44th Annual meeting of Japanese hip society, Oct. 2017, Japanese, Japanese hip society, 東京, Domestic conference

  Oral presentation


• OA軟骨における、アクアポリン1の発現および機能解析

  羽田 勝彦, Hayashi Shinya, Hashimoto Shingo, Matsumoto Tomoyuki, 竹内 一裕, 桐月 伸輔, 黒田 雄一, Kuroda Ryosuke

  The 32nd Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2017, Japanese, The Japanese Orthopaedic Association, 沖縄, Domestic conference

  Poster presentation


• Nitric Oxide Accelerates Cell Proliferation by Preventing BIK Expression in Rheumatoid Arthritis Synovium

  Takeshi Ueha, Sakai Yoshitada, Kohjin Suzuki, Maya Yasuda, Koji Fukuda, Hanako Nishimoto, Hayashi Shinya, Miura Yasushi, Kuroda Ryosuke, Akira Hashiramoto

  19th Asia Pacific League of Associations for Rheumatology Congress, Oct. 2017, English, Dobai, UAE, International conference

  Poster presentation


• Decoy receptor 3は関節リウマチ滑膜細胞におけるCentrosomal protein70kDaの発現を抑制する

  福田 康治, Miura Yasushi, 前田 俊恒, Hayashi Shinya, Kuroda Ryosuke

  The 129ｔｈ Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Oct. 2017, Japanese, Meeting of The Central Japan Association of Orthopaedic Surgery, 富山, Domestic conference

  Oral presentation


• Anterolateral-supine approachによる人工股関節全置換術における臼蓋コンポーネント設置の正確性とリスク因子

  Hashimoto Shingo, Hayashi Shinya, Matsumoto Tomoyuki, Kuroda Ryosuke

  The44th Annual meeting of Japanese hip society, Oct. 2017, Japanese, Japanese hip society, 東京, Domestic conference

  Oral presentation


• ALSアプローチにおけるステム操作時に前捻角をより正確に挿入するための検討

  藤代 高明, 平中 崇文, 岡本 剛治, 飛田 祐一, Hashimoto Shingo, Hayashi Shinya, Kuroda Ryosuke

  The44th Annual meeting of Japanese hip society, Oct. 2017, Japanese, Japanese hip society, 東京, Domestic conference

  Oral presentation


• FAIに対する股関節鏡視下手術の適応と実際

  Hashimoto Shingo, Hayashi Shinya, Matsumoto Tomoyuki, Kuroda Ryosuke

  The 9th of Annual Meething of Japanese Orthopaedic Society of Knee,Arthroscopy and Sports Medicine, Jun. 2017, Japanese, The Japanese Orthopaedic Society of Knee,Arthroscopy and Sports Medicine, 札幌, Domestic conference

  Public symposium


• Changing Anatomic Version Causes Loss of Peri-Prosthetic Bone Density After THA

  Hayashi Shinya, Koji Takayama, Hashimoto Shingo, Matsumoto Tomoyuki, Kuroda Ryosuke

  17th Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery, Jun. 2017, English, Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery, Aachen, Germany, International conference

  Oral presentation


• 単顆型人工膝関節置換術におけるhip-knee-cal-caneus angleによる下肢アライメント評価

  Matsumoto Tomoyuki, 石田 一成, Hashimoto Shingo, Hayashi Shinya, Kuroda Ryosuke

  The 90th Annual Meeting of the Japanese Orthopaedic Association, May 2017, Japanese, The Japanese Orthopaedic Association, 仙台, Domestic conference

  Poster presentation


• 再置換術後の日常活動性に影響する術前因子の検討

  Hayashi Shinya, Hashimoto Shingo, Matsumoto Tomoyuki, Kuroda Ryosuke

  The 90th Annual Meeting of the Japanese Orthopaedic Association, May 2017, Japanese, The Japanese Orthopaedic Association, 仙台, Domestic conference

  Poster presentation


• 術後の陳旧性膝蓋腱断裂と関節不安定性に対しre-revision TKAにBardmeshによる伸展機構再建を併用した1例

  尾ノ井 勇磨, Matsumoto Tomoyuki, Hashimoto Shingo, Hayashi Shinya, Kuroda Ryosuke

  The 128th Meeting of The Central Japan Association of Orthopaedic Surgery and Traumatology, Apr. 2017, Japanese, Meeting of The Central Japan Association of Orthopaedic Surgery, 神戸, Domestic conference

  Oral presentation


• リウマチ滑膜の低ミトコンドリア生合成は滑膜増殖を亢進させ関節破壊の誘導に寄与する

  上羽 岳志, Sakai Yoshitada, 前田俊恒, 西本華子, Hayashi Shinya, Hashimoto Shingo, 福田康治, Miura Yasushi, 黒坂昌弘, 柱本照, Kuroda Ryosuke

  第61回日本リウマチ学会, Apr. 2017, Japanese, 福岡, Domestic conference

  Oral presentation


• TKAにおける目指すべきアライメントとは?

  Matsumoto Tomoyuki, 石田 一成, Hayashi Shinya, Hashimoto Shingo, Kuroda Ryosuke

  The 128th Meeting of The Central Japan Association of Orthopaedic Surgery and Traumatology, Apr. 2017, Japanese, Meeting of The Central Japan Association of Orthopaedic Surgery, 神戸, Domestic conference

  Public discourse


• 過度な前捻コントロールは術後ストレスシールディングを引き起こす

  Hayashi Shinya, Hashimoto Shingo, Matsumoto Tomoyuki, 髙山 孝治, Kuroda Ryosuke

  The 11th Computer Assisted Orthopaedic Surgery, Mar. 2017, Japanese, Computer Assisted Orthopaedic Surgery, 新潟, Domestic conference

  Oral presentation


• ナビゲーションシステムを使用したキネマティックアライメント法によるTKAの臨床成績

  Matsumoto Tomoyuki, 髙山 孝治, 石田 一成, 井口 貴雄, 黒田 雄一, 桐月 伸輔, Hashimoto Shingo, Hayashi Shinya, Kuroda Ryosuke

  The 11th Computer Assisted Orthopaedic Surgery, Mar. 2017, Japanese, Computer Assisted Orthopaedic Surgery, 新潟, Domestic conference

  Oral presentation


• The study of AQP9 in the normal human articular chondrocytes.

  Kazuhiro Takeuchi, Hayashi Shinya, Hashimoto Shingo, Shinsuke Kihara, Masahiko Haneda, Kuroda Ryosuke

  The 30th Annual Meeting of the Japanese Society of Cartilage Metabolism, Mar. 2017, Japanese, The Japanese Society for Bone and Mineral Reserch, 京都, Domestic conference

  Oral presentation


• Aquaporin 1 regulates ADAMTS-4 expression through MAPK pathway in chondrocytes of OA

  羽田 勝彦, Hayashi Shinya, Hashimoto Shingo, 木原 伸介, 竹内 一裕, Matsushita Takehiko, Kuroda Ryosuke

  The 30th Annual Meeting of the Japanese Society of Cartilage Metabolism, Mar. 2017, Japanese, The Japanese Society for Bone and Mineral Reserch, 京都, Domestic conference

  Oral presentation


• Enhancement of mitochondrial biogenesis inhibits cell proliferation by inducing internal apoptosis of rheumatoid arthritis fibroblast-like synovial cell and joint destruction of an arthritis model mice

  Takeshi Ueha, Sakai Yoshitada, Toshihisa Maeda, Masayuki Morishita, Hanako Nishimoto, Risa Harada, Miho Inoue, Shiho Akahane, Koji Fukuda, Hayashi Shinya, Miura Yasushi, Akira Hashiramoto, Masahiro Kurosaka, Kuroda Ryosuke

  The Orthopaedic Research Society 2017 Annual Meeting, Mar. 2017, English, Orthopaedic Research Society, サンディエゴ, アメリカ合衆国, International conference

  Poster presentation


• Cyclin-dependent kinase inhibitor-1 deficiency increases susceptibility to osteoarthritis with inflammation

  Shinsuke Kihara, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, Nobuaki Chinzei, Masahiko Haneda, Kazuhiro Takeuchi, Kuroda Ryosuke

  The 63rd Annual Meeting of the Orthopaedic Research Society, Mar. 2017, English, The Orthopaedic Research Society, San Diego, USA, International conference

  Poster presentation


• CT-free navigation systemを使用したTKAの患者立脚型中期臨床成績

  黒田 雄一, Matsumoto Tomoyuki, 髙山 孝治, Hayashi Shinya, Hashimoto Shingo, Kuroda Ryosuke

  The 11th Computer Assisted Orthopaedic Surgery, Mar. 2017, Japanese, Computer Assisted Orthopaedic Surgery, 新潟, Domestic conference

  Oral presentation


• 同一術者による短外旋筋群温存ALSアプローチにおけるステムの違いが前捻角に与える影響

  藤代 高明, 平中 崇文, 飛田 祐一, Hashimoto Shingo, Hayashi Shinya, Kuroda Ryosuke

  The 47th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2017, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Oral presentation


• 人工膝関節全置換術における異なるtensor systemでの術中軟部組織バランスの比較

  桐月 伸輔, Matsumoto Tomoyuki, 髙山 孝治, 井口 貴雄, 黒田 雄一, 竹内 一裕, 羽田 勝彦, 木原 伸介, Hashimoto Shingo, Hayashi Shinya, Kuroda Ryosuke

  The 47th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2017, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Poster presentation


• 再置換術後日常活動性に影響する因子

  Hayashi Shinya, Hashimoto Shingo, 髙山 孝治, Matsumoto Tomoyuki, Kuroda Ryosuke

  The 47th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2017, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Oral presentation


• ステム周囲のX線学的骨萎縮評価と骨密度との関連性

  羽田 勝彦, Hayashi Shinya, Hashimoto Shingo, Matsumoto Tomoyuki, 髙山 孝治, 木原 伸介, 桐月 伸輔, 竹内 一裕, 黒田 雄一, Kuroda Ryosuke

  The 47th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2017, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Poster presentation


• キネマティックアライメント法によるTKAのX線評価と臨床成績

  Matsumoto Tomoyuki, 髙山 孝治, 石田 一成, 井口 貴雄, 桐月 伸輔, 黒田 雄一, Hayashi Shinya, Hashimoto Shingo, Kuroda Ryosuke

  The 47th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2017, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Oral presentation


• Tri-Lock BPS stem使用症例における髄腔形状と成績の関係

  木原 伸介, Hayashi Shinya, Matsumoto Tomoyuki, Hashimoto Shingo, 髙山 孝治, 井口 貴雄, 桐月 伸輔, 羽田 勝彦, 竹内 一裕, 黒田 雄一, Kuroda Ryosuke

  The 47th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2017, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Poster presentation


• Tapered Wedge型ステムにおけるHAコーティングが早期固着に与える影響

  Hashimoto Shingo, Hayashi Shinya, 髙山 孝治, Matsumoto Tomoyuki, Kuroda Ryosuke

  The 47th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2017, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Poster presentation


• Hip-knee-calcaneus angleによる単顆型人工膝関節置換術術後下肢アライメント評価

  髙山 孝治, Matsumoto Tomoyuki, 石田 一成, Hashimoto Shingo, Hayashi Shinya, Kuroda Ryosuke

  The 47th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2017, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Oral presentation


• Anthology Hip SystemのDEXAによる術後2年の骨密度変化の検討

  竹内 一裕, Hashimoto Shingo, Matsumoto Tomoyuki, Hayashi Shinya, 髙山 孝治, 木原 伸介, 井口 貴雄, 桐月 伸輔, 黒田 雄一, Kuroda Ryosuke

  The 47th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2017, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Poster presentation


• エイコサペンタエン酸徐放ゲルは変形性関節症の進行を抑制する

  木原 伸介, Hayashi Shinya, 明石 祐典, 永田 純平, 竹内 一裕, 羽田 勝彦, 鎮西 伸顕, Kanzaki Noriyuki, Hashimoto Shingo, 田畑 泰彦, Kuroda Ryosuke

  第6回DDS再生医療研究会, Dec. 2016, Japanese, DDS再生医療研究会, 神戸, Domestic conference

  Oral presentation


• 人工股関節全置換術後のstem周囲の骨密度に影響を与える因子の検討

  木原 伸介, Hayashi Shinya, Matsumoto Tomoyuki, Hashimoto Shingo, 髙山 孝治, 羽田 勝彦, 竹内 一裕, Kuroda Ryosuke

  The 43ｒd Annual Meeting of Japanese Hip Society, Nov. 2016, Japanese, The Japanese Hip Society, 大阪, Domestic conference

  Poster presentation


• 再置換術後の日常活動性に影響する因子の検討

  Hayashi Shinya, Hashimoto Shingo, Matsumoto Tomoyuki, 髙山 孝治, 木原 伸介, 羽田 勝彦, 竹内 一裕, Kuroda Ryosuke

  The 43rd Annual Meeting of Japanese Hip Society, Nov. 2016, Japanese, The Japanese Hip Society, 大阪, Domestic conference

  Oral presentation


• 股関節唇損傷形態から考察する股関節鏡視下手術の適応

  Hashimoto Shingo, Hayashi Shinya, 髙山 孝治, 木原 伸介, 羽田 勝彦, 竹内 一裕, Matsumoto Tomoyuki, Kuroda Ryosuke

  The 43ｒd Annual Meeting of Japanese Hip Society, Nov. 2016, Japanese, The Japanese Hip Society, 大阪, Domestic conference

  Others


• ステム周囲のX線学的骨萎縮評価と骨密度との関連性

  羽田 勝彦, Hayashi Shinya, Hashimoto Shingo, 木原 伸介, 竹内 一裕, Kuroda Ryosuke

  The 43ｒd Annual Meeting of Japanese Hip Society, Nov. 2016, Japanese, The Japanese Hip Society, 大阪, Domestic conference

  Poster presentation


• インプラント形状の違いによる骨頭部の回旋抑制性に与える影響

  Hayashi Shinya, Hashimoto Shingo, Matsumoto Tomoyuki, 髙山 孝治, 藤代 高明, 平中 崇文, Kuroda Ryosuke

  The 43rd Annual Meeting of Japanese Hip Society, Nov. 2016, Japanese, The Japanese Hip Society, 大阪, Domestic conference

  Oral presentation


• SMFショートステムの設置アライメントと使用経験

  Hashimoto Shingo, Hayashi Shinya, 髙山 孝治, 木原 伸介, 羽田 勝彦, 竹内 一裕, Matsumoto Tomoyuki, Kuroda Ryosuke

  The 43ｒd Annual Meeting of Japanese Hip Society, Nov. 2016, Japanese, The Japanese Hip Society, 大阪, Domestic conference

  Poster presentation


• Anthology stemにおける術後短期のステム周囲骨密度の検討～HAコーティングの効果について～

  竹内 一裕, Hashimoto Shingo, Matsumoto Tomoyuki, Hayashi Shinya, 髙山 孝治, 木原 伸介, 井口 貴雄, 桐月 伸輔, 羽田 勝彦, 黒田 雄一, Kuroda Ryosuke

  The 43ｒd Annual Meeting of Japanese Hip Society, Nov. 2016, Japanese, The Japanese Hip Society, 大阪, Domestic conference

  Poster presentation


• 人工股関節置換術後のステム周囲の骨密度は術後の活動性と相関する

  Kanzaki Noriyuki, Hayashi Shinya, 羽田 勝彦, Hashimoto Shingo, 木原 伸介, 竹内 一裕, 茨木 一行, Kuroda Ryosuke

  The 18th Annual Meeting of Japan Osteoporosis Society, Oct. 2016, Japanese, Japan Osteoporosis Society, 仙台, Domestic conference

  Oral presentation


• リウマチ滑膜細胞のアポトーシス抵抗性とミトコンドリア機能

  上羽 岳志, Sakai Yoshitada, 森下 雅之, 前田 俊恒, 西本華子, 原田理沙, 井上美帆, 福田 康治, Hayashi Shinya, Hashimoto Shingo, Miura Yasushi, 柱本 照, 黒坂 昌弘, Kuroda Ryosuke

  第3回アニュアルコースレクチャー, Oct. 2016, Japanese, Japan College of Rheumatology, 東京, Domestic conference

  Poster presentation


• ミトコンドリア生合成亢進がリウマチ滑膜の細胞増殖と関節破壊に与える影響

  上羽 岳志, Sakai Yoshitada, 前田 俊恒, 森下 雅之, Hayashi Shinya, 西本 華子, 井上美帆, 原田理沙, 福田 康治, Miura Yasushi, Kuroda Ryosuke, 黒坂 昌弘

  第31回日本整形外科学会基礎学術集会, Oct. 2016, Japanese, The Japanese Orthopaedic Association, 福岡, Domestic conference

  Oral presentation


• エイコサペンタエン酸は酸化ストレス依存性の軟骨細胞の変性、アポトーシスを抑制する

  木原 伸介, Hayashi Shinya, 明石 祐典, 永田 純平, Kanzaki Noriyuki, Hashimoto Shingo, 鎮西 伸顕, 羽田 勝彦, 竹内 一裕, Kuroda Ryosuke, 田畑 泰彦, 黒坂 昌弘

  The 31st Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2016, Japanese, The Japanese Orthopaedic Association, 福岡, Domestic conference

  Oral presentation


• The study of AQP9 in the normal human articular chondrocytes.

  Kazuhiro Takeuchi, Hayashi Shinya, Matsumoto Tomoyuki, Hashimoto Shingo, Koji Takayama, Shinsuke Kihara, Takao Inokuchi, Shinsuke kirizuki, Masahiko Haneda, Yuichi Kuroda, Kuroda Ryosuke

  The 31st Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2016, Japanese, The Japanese Orthopaedic Association, 福岡, Domestic conference

  Poster presentation


• Excessive Stem Version Control Causes Stress Shielding After Total Hip Arthroplasty.

  Hayashi Shinya, Hashimoto Shingo, Kanzaki Noriyuki, Kuroda Ryosuke

  29th Annual Congress of the International Society for Technology in Arthroplasty, Oct. 2016, English, International Society for Technology in Arthroplasty, Boston, USA, International conference

  Poster presentation


• 股関節に生じたpigmented villonodular synovitis（PVNS）に対し股関節鏡を用いて治療を行った一例

  竹内 一裕, Hashimoto Shingo, Matsumoto Tomoyuki, Hayashi Shinya, 髙山 孝治, 木原 伸介, 羽田 勝彦, Kuroda Ryosuke

  The 12th annual meeting of Japanese Society for Hip Arthroscopy, Sep. 2016, Japanese, Annual meeting of Japanese Society for Hip Arthroscopy, 浜松, Domestic conference

  Oral presentation


• The Pathology of hip labrum and chondrolabral junction varies with radiographic parameters.

  Hashimoto Shingo, Hayashi Shinya, Kanzaki Noriyuki, Shinsuke Kihara, Kuroda Ryosuke

  The 8th International Society for Hip Arthroscopy Annual Scientific Meeting, Sep. 2016, English, International Society for Hip Arthroscopy, San Francisco , USA, International conference

  Oral presentation


• 大腿骨頭離断性骨軟骨炎に対してRAO、骨軟骨柱移植術を施行したアメリカンフットボール選手の1例.

  木原 伸介, Hayashi Shinya, Hashimoto Shingo, Kanzaki Noriyuki, 荒木 大輔, Matsushita Takehiko, Kuroda Ryosuke, 黒坂 昌弘

  The 8th Annual Meeting of Japanese Orthopaedis Society of Knee,Arthroscopy and sports Medicine, Jul. 2016, Japanese, The Japanese Orthopaedic Society of Knee,Arthroscopy and Sports Medicine, 福岡, Domestic conference

  Oral presentation


• エイコサペンタエン酸は軟骨細胞の変性と変形性関節症の進行を抑制する

  木原 伸介, Hayashi Shinya, 明石 祐典, 永田 純平, Kanzaki Noriyuki, Hashimoto Shingo, 鎮西 伸顕, 羽田 勝彦, 竹内 一裕, Kuroda Ryosuke, 田畑 泰彦, 黒坂 昌弘

  The 37th annual meeting of the Japanese Society of Inflammation and Regeneration, Jun. 2016, Japanese, The Japanese Society of Inflammation and Regeneration, 京都, Domestic conference

  Poster presentation


• 単純X線像における股関節鏡視下手術の適応と限界

  Hashimoto Shingo, Hayashi Shinya, Kanzaki Noriyuki, Kuroda Ryosuke, 黒坂 昌弘

  The 89th Annual Meeting of the Japanese Orthopaedic Association, May 2016, Japanese, The Japanese Orthopaedic Association, 横浜, Domestic conference

  Others


• 術前の変形性足関節症の病期は人工足関節置換術後の成績に影響があるか?

  Kanzaki Noriyuki, 竹内 一裕, 羽田 勝彦, 木原 伸介, Hashimoto Shingo, Hayashi Shinya, Kuroda Ryosuke, 黒坂 昌弘

  The 89th Annual Meeting of the Japanese Orthopaedic Association, May 2016, Japanese, The Japanese Orthopaedic Association, 横浜, Domestic conference

  Poster presentation


• ミトコンドリア生合成の亢進はコラーゲン誘導性関節炎(CIA)マウスの関節破壊を抑制する

  上羽 岳志, Sakai Yoshitada, 前田 俊恒, Hayashi Shinya, Hashimoto Shingo, 福田 康治, Miura Yasushi, 柱本照, Kuroda Ryosuke, 黒坂 昌弘

  The 60th Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology, Apr. 2016, Japanese, Japan College of Rheumatology, 横浜, Domestic conference

  Poster presentation


• Daily activity and initial spine bone mineral density are associated with periprosthetic bone mineral density.

  羽田 勝彦, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, 鎮西 伸顕, 木原 伸介, 竹内 一裕, Kuroda Ryosuke, Kurosaka Masahiro

  The 46th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2016, Japanese, The Japanese Society for Replacement Arthroplasty, 大阪, Domestic conference

  Poster presentation


• The aquaporin1 water channel expression in human articular chondrocytesis related with inflammation

  Masahiko Haneda, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, Nobuaki Chinzei, Shinsuke Kihara, Kazuhiro Takeuchi, Kuroda Ryosuke, Kurosaka Masahiro

  Orthopaedic Research Society 62nd Annual Meeting 2016, Feb. 2016, English, Orthopaedic Reserch Society, Orlando, USA, International conference

  Poster presentation


• Summit stem使用症例の中期成績

  木原 伸介, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, 鎮西 伸顕, 羽田 勝彦, 竹内 一裕, Kuroda Ryosuke, Kurosaka Masahiro

  The 46th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2016, Japanese, The Japanese Society for Replacement Arthroplasty, 大阪, Domestic conference

  Poster presentation


• p21 deficiency was susceptible to osteoarthritis with inflammation.

  木原 伸介, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, 鎮西 伸顕, 羽田 勝彦, 竹内 一裕, Matsushita Takehiko, 西山 隆之, Kuroda Ryosuke, Kurosaka Masahiro

  The 29th Annual Meeting of ｔhe Japanese Society of Cartilage Metabolism, Feb. 2016, Japanese, The Japanese Society of Cartilage Metabolism, 広島, Domestic conference

  Oral presentation


• p21 deficiency is susceptible to osteoarthritis with inflammation

  Shinsuke Kihara, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, Shuhei Sakata, Nobuaki Chinzei, Masahiko Haneda, Kazuhiro Takeuchi, Kuroda Ryosuke, Kurosaka Masahiro

  Orthopaedic Research Society 62nd Annual Meeting 2016, Feb. 2016, English, Orthopaedic Reserch Society, Orlando, USA, International conference

  Oral presentation


• Aquaporin1 water channel expression in human articular chondrocytes

  羽田 勝彦, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, 鎮西 伸顕, 木原 伸介, 竹内 一裕, Matsushita Takehiko, 西山 隆之, Kuroda Ryosuke, Kurosaka Masahiro

  The 29th Annual Meeting of ｔhe Japanese Society of Cartilage Metabolism, Feb. 2016, Japanese, The Japanese Society of Cartilage Metabolism, 広島, Domestic conference

  Poster presentation


• Anthology Hip SystemのDEXAによる術後骨密度変化の検討

  竹内 一裕, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, 木原 伸介, 羽田 勝彦, Kuroda Ryosuke, Kurosaka Masahiro

  The 46th Annual Meeting of the Japanese Society for replacement arthroplasty, Feb. 2016, Japanese, The Japanese Society for replacement arthroplasty, 大阪, Domestic conference

  Poster presentation


• エイコサペンタエン酸は酸化ストレス依存性の軟骨細胞の変性、アポトーシスを抑制する

  木原 伸介, Hayashi Shinya, 明石 祐典, 永田 純平, 竹内 一裕, 羽田 勝彦, 鎮西 伸顕, Kanzaki Noriyuki, Hashimoto Shingo, Kuroda Ryosuke, 田畑 泰彦, Kurosaka Masahiro

  The 37th Annual Meeting of the Japanese society for Biomaterials, Nov. 2015, Japanese, Ｔhe Japanese society for Biomaterials, 京都, Domestic conference

  Poster presentation


• 股関節疾患のQOL評価の活用法, 各種スコアの比較

  UESUGI YUKO, HAYASHI SHINYA, HASHIMOTO SHINGO, 高尾 正樹, 坂井 孝司, 西井 孝, 菅野 伸彦

  第42回日本股関節学会, Oct. 2015, Japanese, Domestic conference

  Invited oral presentation


• 関節リウマチ滑膜細胞のミトコンドリア機能低下は関節破壊を促進させる

  上羽 岳志, Sakai Yoshitada, 森下 雅之, 前田 俊恒, 原田 理沙, 井上 美帆, 蓑田 正也, 福田 康治, Hayashi Shinya, Miura Yasushi, 柱本 照, Kurosaka Masahiro

  第2回JCRベーシックリサーチカンファレンス, Oct. 2015, Japanese, Japan College of Rheumatology, 東京, Domestic conference

  Poster presentation


• Daily activity and initial spine bone mineral density are associated with periprosthetic bone mineral density.

  羽田 勝彦, Hayashi Shinya, Hashimoto Shingo, Kanzaki Noriyuki, 木原 伸介, 竹内 一裕, Kuroda Ryosuke, Kurosaka Masahiro

  The 42nd Annual Meeting of Japanese Hip Society, Oct. 2015, Japanese, The Japanese Hip Society, 大阪, Domestic conference

  Oral presentation


• ステム前稔アライメントは術後ステム周囲骨密度に影響する

  Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, 西山 隆之, Kuroda Ryosuke, Kurosaka Masahiro

  The 42nd Annual Meeting of Japanese Hip Society, Oct. 2015, Japanese, The Japanese Hip Society, 大阪, Domestic conference

  Oral presentation


• p21 deficiency was susceptible to osteoarthritis with inflammation.

  木原 伸介, Hayashi Shinya, 藤代 高明, Kanzaki Noriyuki, Hashimoto Shingo, 鎮西 伸顕, 羽田 勝彦, Kuroda Ryosuke, Kurosaka Masahiro

  The 30th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2015, Japanese, The 30th Annual Research Meeting of the Japanese Orthopaedic Association, 富山, Domestic conference

  Poster presentation


• Kerboull型プレートを用いた人工股関節再置換術の術後成績に影響する因子の検討

  Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, 西山 隆之, Kuroda Ryosuke, Kurosaka Masahiro

  The 42nd Annual Meeting of Japanese Hip Society, Oct. 2015, Japanese, The Japanese Hip Society, 大阪, Domestic conference

  Oral presentation


• Risk Factor for Failure of Revision Total Hip Arthroplasty Using a Kerboull-Type Acetabular Reinforcement Device.

  Hayashi Shinya, Hashimoto Shingo, Kanzaki Noriyuki, Nobuaki Chinzei, Masahiko Haneda, Shinsuke Kihara, Kazuhiro Takeuchi, Kuroda Ryosuke, Kurosaka Masahiro

  The 28th Annual Congress of International Society for Technology in Arthroplasty., Sep. 2015, Japanese, The International Society for Technology in Arthroplasty, Vienna, Austria, International conference

  Oral presentation


• Daily Activity and Initial Spine Bone Mineral Density Are Associated With Periprosthetic Bone Mineral Density After Total Hip Arthroplasty With a Tapered-Wedge Stem.

  Hayashi Shinya, Hashimoto Shingo, Kanzaki Noriyuki, Kuroda Ryosuke, Kurosaka Masahiro

  The 28th Annual Congress of International Society for Technology in Arthroplasty., Sep. 2015, Japanese, The International Society for Technology in Arthroplasty, Vienna, Austria, International conference

  Oral presentation


• 距骨外側突起骨折後及び腓骨外果骨折後の遺残変形に対する足部内視鏡手術

  木原 伸介, Kanzaki Noriyuki, 藤代 高明, Hayashi Shinya, Hashimoto Shingo, Kuroda Ryosuke, Kurosaka Masahiro

  7th Annual Meeting of Japanese Orthopaedis Society of Knee,Arthroscopy and sports Medicine, Jun. 2015, Japanese, Japanese Orthopaedis Society of Knee,Arthroscopy and sports Medicine, 札幌, Domestic conference

  Oral presentation


• p21 deficiency was susceptible to osteoarthritis with inflammation.

  Shinsuke Kihara, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, Shuhei Sakata, Nobuaki Chinzei, Masahiko Haneda, Koji Fukuda, Toshihisa Maeda, Takaaki Fujishiro, Miura Yasushi, Kuroda Ryosuke, Kurosaka Masahiro

  The 16th Annual European Congress of Rheumatology, Jun. 2015, English, The European League Against Rheumatism, Rome, Italy, International conference

  Oral presentation


• AAIS、PAIS以外の足部インピンジメント症候群に対する足部内視鏡施術

  Kanzaki Noriyuki, 熊井 司, 田中 康仁, 藤代 高明, Hayashi Shinya, Hashimoto Shingo, Kuroda Ryosuke, Kurosaka Masahiro

  7th Annual Meeting of Japanese Orthopaedis Society of Knee,Arthroscopy and sports Medicine, Jun. 2015, Japanese, Japanese Orthopaedis Society of Knee,Arthroscopy and sports Medicine, 札幌, Domestic conference

  Public symposium


• Ｔｒｉ-Lock Bone Preservation StemのDEXAによる術後骨密度変化の検討

  羽田 勝彦, Hayashi Shinya, Kanzaki Noriyuki, 鎮西 伸顕, 木原 伸介, Sakai Yoshitada, Akisue Toshihiro, Kuroda Ryosuke, Kurosaka Masahiro

  The 52nd Annual Meeting of the Japanese Association of Rehabilitation Medicine, May 2015, Japanese, The Japanese Association of Rehabilitation Medicine, 新潟, Domestic conference

  Poster presentation


• 様々な病態が重なり整復不能となった長腓骨筋腱脱臼の1例

  鎮西 伸顕, Kanzaki Noriyuki, Hayashi Shinya, 木原 伸介, 羽田 勝彦, Sakai Yoshitada, Akisue Toshihiro, 西山 隆之, Kuroda Ryosuke, Kurosaka Masahiro

  The 52nd Annual Meeting of the Japanese Association of Rehabilitation Medicine, May 2015, Japanese, The Japanese Association of Rehabilitation Medicine, 新潟, Domestic conference

  Poster presentation


• 筋損傷後の治癒過程におけるｐ21の役割

  鎮西 伸顕, Hayashi Shinya, Kanzaki Noriyuki, 上羽 岳志, 木原 伸介, 羽田 勝彦, Sakai Yoshitada, Akisue Toshihiro, Kuroda Ryosuke, Kurosaka Masahiro

  The 52nd Annual Meeting of the Japanese Association of Rehabilitation Medicine, May 2015, Japanese, The Japanese Association of Rehabilitation Medicine, 新潟, Domestic conference

  Oral presentation


• デノスマブによる骨粗鬆症の治療効果

  Hayashi Shinya, 前田 俊恒, Miura Yasushi, Sakai Yoshitada, Kuroda Ryosuke, Kurosaka Masahiro

  The 52nd Annual Meeting of the Japanese Association of Rehabilitation Medicine, May 2015, Japanese, The Japanese Association of Rehabilitation Medicine, 新潟, Domestic conference

  Oral presentation


• Endoscopic Treatment for deformity after lateral talar process fracture

  Kanzaki Noriyuki, Tsukasa Kumai, Yasuhito Tanaka, Hayashi Shinya, Hashimoto Shingo, Nobuaki Chinzei, Shinsuke Kihara, Masahiko Haneda, Kuroda Ryosuke, Kurosaka Masahiro

  2016 Annual Meeting of the Asia-Pacific Knee, Arthroscopy and Sports Medicine Society, May 2015, Japanese, Ｔhe Asia-Pacific Knee, Arthroscopy and Sports Medicine Society, 台北, 台湾, International conference

  Poster presentation


• RA滑膜細胞のミトコンドリア活性化は細胞増殖とMMP-3/RANKLの分泌を抑制する

  上羽 岳志, Sakai Yoshitada, 前田 俊恒, 福田 康治, Hayashi Shinya, 小林 慶通, 柱本 照, Miura Yasushi, Kurosaka Masahiro

  The 59th Annual Scientific Meeting of Japan College of Rheumatology, Apr. 2015, Japanese, Japan College of Rheumatology, 名古屋, Domestic conference

  Poster presentation


• Tri-Lock Bone Preservation StemのDEXAによる術後骨密度変化の検討

  羽田 勝彦, Fujishiro Takaaki, Hayashi Shinya, Hashimoto Shingo, Kanzaki Noriyuki, 坂田 周平, 鎮西 伸顕, 木原 伸介, Kurosaka Masahiro

  第19回兵庫股関節研究会プログラム, Mar. 2015, Japanese, 兵庫股関節研究会, 神戸, Domestic conference

  Oral presentation


• p21欠損は炎症による変形性関節症を加速させる

  木原 伸介, Hayashi Shinya, Fujishiro Takaaki, Kanzaki Noriyuki, Hashimoto Shingo, 鎮西 伸顕, 羽田 勝彦, Matsushita Takehiko, 西山 隆之, Kuroda Ryosuke, Kurosaka Masahiro

  The 28th Annual Meeting of ｔhe Japanese Society of Cartilage Metabolism, Mar. 2015, Japanese, The Japanese Society of Cartilage Metabolism, 東京, Domestic conference

  Oral presentation


• p21 Deficiency Impaired The Regeneration of Skeletal Muscle

  Nobuaki Chinzei, Hayashi Shinya, Takeshi Ueha, Fujishiro Takaaki, Kanzaki Noriyuki, Hashimoto Shingo, Shuhei Sakata, Shinsuke Kihara, Masahiko Haneda, Sakai Yoshitada, Kuroda Ryosuke, Kurosaka Masahiro

  The 61th Annual Meeting of the Orthopaedic Research Society, Mar. 2015, English, Orthopaedic Research Society, Las Vegas, USA, International conference

  Poster presentation


• Oxidative Stress-induced Apoptosis And Matrix Loss Of Chondrocytes Is Inhibited By Eicosapentaenoic Acid

  Masahiko Haneda, Hayashi Shinya, Shuhei Sakata, Fujishiro Takaaki, Kanzaki Noriyuki, Hashimoto Shingo, Nobuaki Chinzei, Shinsuke Kihara, Kuroda Ryosuke, Kurosaka Masahiro

  The 61th Annual Meeting of the Orthopaedic Research Society, Mar. 2015, English, Orthopaedic Research Society, Las Vegas, USA, International conference

  Oral presentation


• Molecular Characteristics Proving Femoroacetabular Impingement As The Precursor To Hip Osteoarthritis

  Nobuaki Chinzei, Hashimoto Shingo, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Masahisa Hatakeyama, Shuhei Sakata, Shinsuke Kihara, Masahiko Haneda, Soshi Uchida, Kuroda Ryosuke, Kurosaka Masahiro

  The 61th Annual Meeting of the Orthopaedic Research Society, Mar. 2015, English, Orthopaedic Research Society, Las Vegas, USA, International conference

  Poster presentation


• Centrosomal Protein 70kda Is Down-regulatedBy Decoy Receptor 3 In Specifically RheumatoidSynovial Fibroblasts

  Koji Fukuda, Miura Yasushi, Toshihisa Maeda, Hayashi Shinya, Kurosaka Masahiro

  2015 Annual Meeting of the Orthopaedic Research Society, Mar. 2015, English, The Orthopaedic Research Sosiety, Las Vegas, USA, International conference

  Poster presentation


• 大腿骨側ステムのアライメントはステムデザインにより影響を受けるない

  鎮西 伸顕, Hayashi Shinya, Fujishiro Takaaki, Kanzaki Noriyuki, Hashimoto Shingo, 坂田 周平, 木原 伸介, 羽田 勝彦, Kuroda Ryosuke, Kurosaka Masahiro

  The 45th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2015, Japanese, The Japanese Society for Replacement Arthroplasty, 福岡, Domestic conference

  Poster presentation


• 人工足関節置換術において術前可動域は術後可動域に影響を与えるか?

  Kanzaki Noriyuki, 高倉 義典, 高倉 義幸, Fujishiro Takaaki, Hayashi Shinya, Hashimoto Shingo, 鎮西 伸顕, 木原 伸介, 羽田 勝彦, 西山 隆之, Kuroda Ryosuke, Kurosaka Masahiro

  The 45th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2015, Japanese, The Japanese Society for Replacement Arthroplasty, 福岡, Domestic conference

  Oral presentation


• Tri-Lock Bone Preservation StemのDEXAによる術後骨密度変化の検討

  羽田 勝彦, Fujishiro Takaaki, Hayashi Shinya, Hashimoto Shingo, Kanzaki Noriyuki, 坂田 周平, 鎮西 伸顕, 木原 伸介, Kurosaka Masahiro

  The 45th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2015, Japanese, The Japanese Society for Replacement Arthroplasty, 福岡, Domestic conference

  Poster presentation


• THAにおける手術進入路の違いが術後可動域に与える影響

  Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, 坂田 周平, 鎮西 伸顕, 木原 伸介, 羽田 勝彦, Kurosaka Masahiro

  The 45th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2015, Japanese, The Japanese Society for Replacement Arthroplasty, 福岡, Domestic conference

  Oral presentation


• Summit stem使用症例の4年成績

  木原 伸介, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, 坂田 周平, 鎮西 伸顕, 羽田 勝彦, Kuroda Ryosuke, Kurosaka Masahiro

  The 45th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2015, Japanese, The Japanese Society for Replacement Arthroplasty, 福岡, Domestic conference

  Poster presentation


• Kerboull型プレートを用いた人工股関節再置換術の術後成績

  Hayashi Shinya, 西山 隆之, Fujishiro Takaaki, Kanzaki Noriyuki, Hashimoto Shingo, Kurosaka Masahiro

  The 45th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2015, Japanese, The Japanese Society for Replacement Arthroplasty, 福岡, Domestic conference

  Oral presentation


• 60才未満に対する人工股関節全置換術後のADLと職場復帰について

  Hashimoto Shingo, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 武部 健, 島 直子, 寺島 康浩, 柴沼 均, Kurosaka Masahiro

  The 45th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2015, Japanese, The Japanese Society for Replacement Arthroplasty, 福岡, Domestic conference

  Poster presentation


• MDCT画像を用いたTHAカップ設置角度計測法と再現性評価

  小橋 昌司, 岩佐 賢二郎, Fujishiro Takaaki, Hayashi Shinya, Hashimoto Shingo, Kuroda Ryosuke, Kurosaka Masahiro, 上浦 尚武

  The 41st Annual Meetihg of the Japanese Society for Clinical Biomechanics, Nov. 2014, Japanese, The Japanese Society for Clinical Biomechanics, 奈良, Domestic conference

  Oral presentation


• 大腿骨側ステムのアライメントはステムデザインにより影響を受ける

  Hayashi Shinya, Fujishiro Takaaki, Kanzaki Noriyuki, Hashimoto Shingo, Kurosaka Masahiro

  The 41th Annual Meeting of Japanese Hip Society, Oct. 2014, Japanese, The Japanese Hip Society, 東京, Domestic conference

  Oral presentation


• 若年者に対するTHA前後の骨盤アライメントが下肢筋発揮効率に影響を与えた1症例

  中 雄太, 柴沼 均, Fujishiro Takaaki, Hayashi Shinya, Hashimoto Shingo, 木下 和昭

  The 41th Annual Meeting of Japanese Hip Society, Oct. 2014, Japanese, The Japanese Hip Society, 東京, Domestic conference

  Oral presentation


• 在宅患者の運動継続支援へのICTの有効活用―運動療法webでの双方向的なコメント分析―

  山田 知沙, UESUGI YUKO, HAYASHI SHINYA, HASHIMOTO SHINGO, FUJISHIRO TAKAAKI

  第41回日本股関節学会学術集会, Oct. 2014, Japanese, Domestic conference

  Oral presentation


• 股関節唇損傷症例におけるX線学的指標・臨床所見・関節軟骨損傷の関連

  Hashimoto Shingo, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Kuroda Ryosuke, Kurosaka Masahiro

  The 41th Annual Meeting of Japanese Hip Society, Oct. 2014, Japanese, The Japanese Hip Society, 東京, Domestic conference

  Oral presentation


• 筋損傷後の治癒過程におけるp21の役割

  木原 伸介, Hayashi Shinya, 上羽 岳志, Hashimoto Shingo, Fujishiro Takaaki, Kanzaki Noriyuki, 鎮西 伸顕, 坂田 周平, Sakai Yoshitada, Kuroda Ryosuke, Kurosaka Masahiro

  第29回日本整形外科学会基礎学術集会, Oct. 2014, Japanese, 日本整形外科学会, 鹿児島, Domestic conference

  Oral presentation


• Tri-Lock Bone Preservation StemのDEXAによる術後骨密度変化の検討

  羽田 勝彦, Hayashi Shinya, Fujishiro Takaaki, Hashimoto Shingo, Kanzaki Noriyuki, 坂田 周平, 鎮西 伸顕, 木原 伸介, Kuroda Ryosuke, Kurosaka Masahiro

  The 41th Annual Meeting of Japanese Hip Society, Oct. 2014, Japanese, The Japanese Hip Society, 東京, Domestic conference

  Oral presentation


• The diagnostic potential of biochemical MRI for articular cartilage damage of femoroacetabular impingement.

  Hashimoto Shingo, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Kurosaka Masahiro

  The 11th Congress of European Hip Society, Oct. 2014, English, European Hip Society, Stockholm, Sweden, International conference

  Poster presentation


• THAにおける手術進入路は術後可動域に影響するか-同一術者による後方と前側方、前方アプローチの比較-

  Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, 坂田 周平, 鎮西 伸顕, 木原 伸介, 羽田 勝彦, Kurosaka Masahiro

  The 41th Annual Meeting of Japanese Hip Society, Oct. 2014, Japanese, The Japanese Hip Society, 東京, Domestic conference

  Oral presentation


• THAにおける手術進入路はインプラント設置角度に影響するか-同一術者による後方と前側方アプローチの比較-

  Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, 坂田 周平, 鎮西 伸顕, 木原 伸介, 羽田 勝彦, Kurosaka Masahiro

  The 41th Annual Meeting of Japanese Hip Society, Oct. 2014, Japanese, The Japanese Hip Society, 東京, Domestic conference

  Oral presentation


• Summit stem使用症例の4年成績

  木原 伸介, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, 坂田 周平, 鎮西 伸顕, 羽田 勝彦, Kurosaka Masahiro

  The 41th Annual Meeting of Japanese Hip Society, Oct. 2014, Japanese, The Japanese Hip Society, 東京, Domestic conference

  Oral presentation


• painDETECTによる股関節疾患患者の神経障害性疼痛の実態調査

  UESUGI YUKO, HAYASHI SHINYA, HASHIMOTO SHINGO, 西山隆之

  第41回日本股関節学会学術集会, Oct. 2014, Japanese, Domestic conference

  Poster presentation


• Molecular characteristic of the tissues from hips with femoroacetabular impingement.

  Fujishiro Takaaki, Hashimoto Shingo, Nobuaki Chinzei, Hayashi Shinya, Kanzaki Noriyuki, Masahisa Hatakeyama, Shuhei Sakata, Shinsuke Kihara, Soshi Uchida, Kurosaka Masahiro

  The 11th Congress of European Hip Society, Oct. 2014, English, European Hip Society, Stockholm, Sweden, International conference

  Poster presentation


• Kerboull型プレートを用いた人工股関節再置換術の術後成績

  Hayashi Shinya, Fujishiro Takaaki, Kanzaki Noriyuki, Hashimoto Shingo, 西山 隆之, Kurosaka Masahiro

  The 41th Annual Meeting of Japanese Hip Society, Oct. 2014, Japanese, The Japanese Hip Society, 東京, Domestic conference

  Oral presentation


• FAIの分子生物学的特徴

  鎮西 伸顕, Hashimoto Shingo, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 坂田 周平, 木原 伸介, 羽田 勝彦, 内田 宗志, Kurosaka Masahiro

  The 41th Annual Meeting of Japanese Hip Society, Oct. 2014, Japanese, The Japanese Hip Society, 東京, Domestic conference

  Oral presentation


• 3Dテンプレートソフトを用いたエクセターステムの設置評価

  柴沼 均, Fujishiro Takaaki, Hayashi Shinya, Hashimoto Shingo, Kurosaka Masahiro

  The 41th Annual Meeting of Japanese Hip Society, Oct. 2014, Japanese, The Japanese Hip Society, 東京, Domestic conference

  Oral presentation


• 人工足関節置換術の現状と未来

  Kanzaki Noriyuki, 高倉 義典, Fujishiro Takaaki, Hayashi Shinya, Hashimoto Shingo, Kuroda Ryosuke, Kurosaka Masahiro

  6th Annual Meeting of Japanese Orthopaedic Society of Knee,Arthroscopy and Sports Medicine, Jul. 2014, Japanese, Japanese Orthopaedic Society of Knee,Arthroscopy and Sports Medicine, 広島, Domestic conference

  [Invited]

  Nominated symposium


• 有症性の両側第4腓骨筋腱に対する治療経験

  鎮西 伸顕, Kanzaki Noriyuki, Hayashi Shinya, 木原 伸介, Sakai Yoshitada, Akisue Toshihiro, Kuroda Ryosuke, Kurosaka Masahiro

  The 51th Annual Meeting of the Japanese Association of Rehabilitation Medicine, Jun. 2014, Japanese, The Japanese Association of Rehabilitation Medicine, 名古屋, Domestic conference

  Poster presentation


• 距骨に骨軟骨腫を生じた一例

  木原 伸介, Kanzaki Noriyuki, Akisue Toshihiro, Hayashi Shinya, 鎮西 伸顕, Sakai Yoshitada, Kuroda Ryosuke, Kurosaka Masahiro

  The 51th Annual Meeting of the Japanese Association of Rehabilitation Medicine, Jun. 2014, Japanese, The Japanese Association of Rehabilitation Medicine, 名古屋, Domestic conference

  Poster presentation


• G2ステム使用症例の短中期成績

  鎮西 伸顕, Hayashi Shinya, Kanzaki Noriyuki, 木原 伸介, Sakai Yoshitada, Akisue Toshihiro, Kuroda Ryosuke, Kurosaka Masahiro

  The 51th Annual Meeting of the Japanese Association of Rehabilitation Medicine, Jun. 2014, Japanese, The Japanese Association of Rehabilitation Medicine, 名古屋, Domestic conference

  Poster presentation


• Accuracy of three-dimensional preoperative templating in total hip arthroplasty using navigation.

  Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, Kurosaka Masahiro

  14th Annual Meeting of International Society for Computer Assisted Orthopaedic Surgery, Jun. 2014, English, International Society for Computer Assisted Orthopaedic Surgery, Milano, Italy, International conference

  Poster presentation


• Accuracy of stem alignment is affected by stem design and surgical approach.

  Hayashi Shinya, Fujishiro Takaaki, Hashimoto Shingo, Kanzaki Noriyuki, Kurosaka Masahiro

  14th Annual Meeting of International Society for Computer Assisted Orthopaedic Surgery, Jun. 2014, English, International Society for Computer Assisted Orthopaedic Surgery, Milano, Italy, International conference

  Poster presentation


• 足関節以外の足部インピンジメント症候群に対する足部内視鏡手術

  Kanzaki Noriyuki, 熊井 司, 田中 康仁, Fujishiro Takaaki, Hayashi Shinya, Hashimoto Shingo, Kuroda Ryosuke, Kurosaka Masahiro

  The 87th Annual Meeting of the Japanese Orthopaedic Association, May 2014, Japanese, The Japanese Orthopaedic Association, 神戸, Domestic conference

  Oral presentation


• ディシジョンツリー分析を用いた人工股関節全置換術後在院日数予測モデルの構築(第2報)

  中村 瑠美, 山口 良太, 丸山 孝樹, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, Sakai Yoshitada

  第49回日本理学療法学術大会, May 2014, Japanese, 日本理学療法士協会, 横浜, Domestic conference

  Oral presentation


• Kerboull型プレートを用いた人工股関節再置換術の術後成績

  Hayashi Shinya, Fujishiro Takaaki, Kanzaki Noriyuki, Hashimoto Shingo, 西山 隆之, Kuroda Ryosuke, Kurosaka Masahiro

  The 87th Annual Meeting of the Japanese Orthopaedic Association, May 2014, Japanese, The Japanese Orthopaedic Association, 神戸, Domestic conference

  Public symposium


• Femoroacetabular impingementに対する画像診断

  Hashimoto Shingo, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Kuroda Ryosuke, Kurosaka Masahiro

  The 87th Annual Meeting of the Japanese Orthopaedic Association, May 2014, Japanese, The Japanese Orthopaedic Association, 神戸, Domestic conference

  Oral presentation


• Remote assessments and instructions for home-rehabilitation via custom-made website in patients with hip and knee osteoarthritis; A preliminary report. World congress on osteoarthritis

  UESUGI YUKO, 西井 千佳, 山田 知沙, HAYASHI SHINYA, FUJISHIRO TAKAAKI, KURODA RYOSUKE, HASHIMOTO SHINGO, MATSUSHITA TAKEHIKO, MATSUMOTO TOMOYUKI, 西井 孝

  OARSI, Apr. 2014, Japanese, International conference

  Poster presentation


• PTEN Regulates Matrix Synthesis in Adult HumanChondrocytes under Oxidative Stress

  Kenjiro Iwasa, Hayashi Shinya, Fujishiro Takaaki, Kanzaki Noriyuki, Shingo Hashimoto, Shuhei Sakata, Nobuaki Chinzei, Kuroda Ryosuke, Kurosaka Masahiro

  The 60th Annual Meeting of Orthopaedic Research Society, Mar. 2014, English, Orthopaedic Research Society, New Orleans, USA, International conference

  Poster presentation


• P21 Regulates Mmp-13 Expression Through Stat3 Signaling In Chondrocytes

  Hayashi Shinya, Fujishiro Takaaki, Shingo Hashimoto, Kanzaki Noriyuki, Kenjiro Iwasa, Shuhei Sakata, Nobuaki Chinzei, Shinsuke Kihara, Kuroda Ryosuke, Kurosaka Masahiro

  The 60th Annual Meeting of Orthopaedic Research Society, Mar. 2014, English, Orthopaedic Research Society, New Orleans, USA, International conference

  Poster presentation


• Cyclin-dependent Kinase Inhibitor, P21 Is Not Essential For Endochondral Ossification

  Nobuaki Chinzei, Hayashi Shinya, Shingo Hashimoto, Kanzaki Noriyuki, Kenjiro Iwasa, Shuhei Sakata, Shinsuke Kihara, Fujishiro Takaaki, Kuroda Ryosuke, Kurosaka Masahiro

  The 60th Annual Meeting of Orthopaedic Research Society, Mar. 2014, English, Orthopaedic Research Society, New Orleans, USA, International conference

  Poster presentation


• CT-based fluoroscopic matching navigation systemを使用したTHAの大腿骨コンポーネント設置精度における検討

  Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, Kuroda Ryosuke, Kurosaka Masahiro

  The 87th Annual Meeting of the Japanese Orthopaedic Association, Mar. 2014, Japanese, The Japanese Orthopaedic Association, 神戸, Domestic conference

  Oral presentation


• 3Dテンプレートによる術前予定ステムサイズと術中選択サイズの検討

  Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Hashimoto Shingo, Kurosaka Masahiro, 柴沼 均

  The 8th Annual Meeting of Japanese Computer Assisted Orthopaedic Surgery, Mar. 2014, Japanese, The Japanese Computer Assisted Orthopaedic Surgery, 横浜, Domestic conference

  Oral presentation


• Ｇ2ステム使用症例の短中期成績

  鎮西 伸顕, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, 岩佐 賢二郎, 坂田 周平, 木原 伸介, Kuroda Ryosuke, Kurosaka Masahiro

  The 44th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2014, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Poster presentation


• ＡＲＭＤにより臼蓋コンポーネント周囲に巨大な骨欠損を生じた1例

  岩佐 賢二郎, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, Kurosaka Masahiro

  The 44th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2014, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Poster presentation


• 手術アプローチの違いによるTHA術後可動域における検討

  Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, 岩佐 賢二郎, 坂田 周平, 鎮西 伸顕, 木原 伸介, Kurosaka Masahiro, 柴沼 均

  The 44th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2014, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Oral presentation


• 高位脱臼股に対するセメントレス人工股関節全置換術の臨床成績

  橋本 慎吾, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 岩佐 賢二郎, 坂田 周平, 鎮西 伸顕, 木原 伸介, Kurosaka Masahiro

  The 44th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2014, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Poster presentation


• アルミセラミック骨頭の破損をきたしたセラミック人工股関節の1例

  柴沼 均, Fujishiro Takaaki, 佐々木 宏, 杜多 昭彦, 石田 一成, Hayashi Shinya, 橋本 慎吾, Kurosaka Masahiro

  The 44th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2014, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Poster presentation


• TNK人工足関節置換術後の足関節可動域についての検討

  Kanzaki Noriyuki, 高倉 義幸, 杜多 昭彦, 柴沼 均, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  The 44th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2014, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Oral presentation


• RA患者におけるＴＨＡ術後の遅発性感染の要因－生物学製剤はリスクファクターになりうるか－

  Hayashi Shinya, Fujishiro Takaaki, 橋本 慎吾, Kanzaki Noriyuki, Kurosaka Masahiro

  The 44th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2014, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Oral presentation


• 3Ｄテンプレートによる術前予定ステムサイズと術中選択サイズの検討

  Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, 岩佐 賢二郎, 坂田 周平, 鎮西 伸顕, 木原 伸介, Kurosaka Masahiro, 柴沼 均

  The 44th Annual Meeting of the Japanese Society for Replacement Arthroplasty, Feb. 2014, Japanese, The Japanese Society for Replacement Arthroplasty, 沖縄, Domestic conference

  Oral presentation


• The diagnostic potential of biochemical MRI for articular cartilage damage of femoroacetabular impingement.

  Hashimoto Shingo, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Goto Hajimu, Kuroda Ryosuke, Kurosaka Masahiro

  The Asian Pacific Hip Arthroscopy Meeting 2014., Jan. 2014, English, The Asian Pacific Hip Arthroscopy Meeting, 北九州, International conference

  Oral presentation


• Molecular characteristic of the tissues from hips with femoroacetabular impingement

  Nobuaki Chinzei, Shingo Hashimoto, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Masahisa Hatakeyama, Shuhei Sakata, Shinsuke Kihara, Kuroda Ryosuke, Soshi Uchida, Kurosaka Masahiro

  The Asia Pacific Hip Arthroscopy Meeting 2014, Jan. 2014, English, The Asia Pacific Hip Arthroscopy, 北九州, International conference

  Oral presentation


• ＲＡ患者におけるＴＨＡ術後の遅発性感染の要因-生物学製剤はリスクファクターになりうるのか

  Hayashi Shinya, Fujishiro Takaaki, 橋本 慎吾, Kanzaki Noriyuki, 岩佐 賢二郎, 木原 伸介, 西山 隆之, Kurosaka Masahiro

  The 40th Annual Meeting of Japanese Hip Society, Nov. 2013, Japanese, The Japanese Hip Society, 広島, Domestic conference

  Oral presentation


• 人工股関節置換術後患者の公共交通機関利用の不安と困難について

  小西 美穂, Uesugi Yuko, 佐成 優佳, Hayashi Shinya, 橋本 慎吾, Kanzaki Noriyuki, 木原 伸介, 岩佐 賢二郎, 西山 隆之, Fujishiro Takaaki

  The 40th Annual Meeting of Japanese Hip Society, Nov. 2013, Japanese, The Japanese Hip Society, 広島, Domestic conference

  Oral presentation


• summit使用症例の短期成績

  木原 伸介, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, 岩佐 賢二郎, 坂田 周平, 鎮西 伸顕, Kurosaka Masahiro

  The 40th Annual Meeting of Japanese Hip Society, Nov. 2013, Japanese, The Japanese Hip Society, 広島, Domestic conference

  Oral presentation


• Fixation of osteochondral lesions of the talus using bone pegs: a report of two cases

  Kanzaki Noriyuki, Fujishiro Takaaki, Hayashi Shinya, Shingo Hashimoto, Kuroda Ryosuke, Kurosaka Masahiro

  The 5th Scientific Meeting of Asian Federation of Foot and Ankle Surgeons, Nov. 2013, English, The Asian Federation of Foot and Ankle Surgeons, 香港, 中国, International conference

  Poster presentation


• 3Ｄテンプレートソフトを用いたZweymuller型ステムの固定様式の検討

  柴沼 均, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, Kurosaka Masahiro

  The 40th Annual Meeting of Japanese Hip Society, Nov. 2013, Japanese, The Japanese Hip Society, 広島, Domestic conference

  Oral presentation


• 距骨に骨軟骨腫を生じた一例

  木原 伸介, Kanzaki Noriyuki, Akisue Toshihiro, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  The 38th Annual Meeting of Japanese Society for Surgery of the Foot, Oct. 2013, Japanese, The Japanese Society for Surgery of the Foot, 仙台, Domestic conference

  Poster presentation


• 関節リウマチ患者に対する人工股関節全置換術後在院日数予測モデルの逸脱要因～ディシジョンツリー分析を用いた検討～

  中村瑠美, 山口良太, 丸山孝樹, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本慎吾, Sakai Yoshitada

  第28回日本RAのリハビリ研究会学術集会, Oct. 2013, Japanese, 日本RAのリハビリ研究会, 神戸, 決定木分析を用いてTHA患者の検討を行い、ＲＡ患者における逸脱要因を検討した, Domestic conference

  Oral presentation


• ヒト軟骨細胞においてPTENは酸化ストレス下に基質の産生を調整する

  岩佐 賢二郎, Hayashi Shinya, Fujishiro Takaaki, Kanzaki Noriyuki, 橋本 慎吾, 坂田 周平, 鎮西 伸顕, Kuroda Ryosuke, Kurosaka Masahiro

  The 28th annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2013, Japanese, The Japanese Orthopaedic Association, 千葉, Domestic conference

  Oral presentation


• カシンベック病に伴う変形性足関節症に対し鏡視下足関節固定術をおこなった症例

  Fujishiro Takaaki, Kanzaki Noriyuki, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  The 38th Annual Meeting of Japanese Society for Surgery of the Foot, Oct. 2013, Japanese, The Japanese Society for Surgery of the Foot, 仙台, Domestic conference

  Poster presentation


• エイコサペンタエン酸はストレス依存性の軟骨細胞の変性、アポトーシスを抑制する

  木原 伸介, 坂田 周平, Hayashi Shinya, Fujishiro Takaaki, Kanzaki Noriyuki, 橋本 慎吾, 岩佐 賢二郎, 鎮西 伸顕, Kuroda Ryosuke, Kurosaka Masahiro

  The 28th annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2013, Japanese, The Japanese Orthopaedic Association, 千葉, Domestic conference

  Oral presentation


• TNK人工足関節置換術後の足関節可動域についての検討

  Kanzaki Noriyuki, 高倉 義典, 高倉 義幸, 杜多 昭彦, 柴沼 均, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  The 39th Annual Meeting of the Japanese Society for Surgery of the Foot, Oct. 2013, Japanese, The Japanese Society for Surgery of the Foot, 仙台, Domestic conference

  Oral presentation


• Excessive femoral offset does not affect the range of motion after total hip arthroplasty

  Hayashi Shinya, Takayuki Nishiyama, Fujishiro Takaaki, Shingo Hashimoto, Kanzaki Noriyuki, Nishida Kotaro, Kurosaka Masahiro, Kuroda Ryosuke

  The Annual Meeting of 2013 International Society for Technology in Arthroplasty, Oct. 2013, English, The International Society for Technology in Arthroplasty, Palm Beach, USA, International conference

  Poster presentation


• Detection of articular cartilage damage with T1 rho MRI on FAI patients

  Shingo Hashimoto, Fujishiro Takaaki, Hayashi Shinya, Hajime Goto, Kuroda Ryosuke, Kurosaka Masahiro

  The Annual Meeting of 2013 International Society for Hip Arthroscopy, Oct. 2013, English, The International Society for Hip Arthroscopy, Munich, Deutschland, International conference

  Poster presentation


• Fixation of osteochondral lesions of the talus using bone pegs: a report of two cases

  Kanzaki Noriyuki, Fujishiro Takaaki, Hayashi Shinya, Shingo Hashimoto, Kuroda Ryosuke, Kurosaka Masahiro

  The 11th world Congress of the International Cartilage Repair Society, Sep. 2013, English, The International Cartilage Repair Society, Izmir, Republic of Turkey, International conference

  Poster presentation


• カシンベック病に伴う変形性足関節症に対し鏡視下足関節固定術をおこなった症例

  Kanzaki Noriyuki, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  5th Annual Meeting of Japanese Orthopaedic Society of Knee,Arthroscopy and Sports Medicine, Jun. 2013, Japanese, Japanese Orthopaedic Society of Knee,Arthroscopy and Sports Medicine, 札幌, Domestic conference

  Poster presentation


• Femoroacetabular Impingementにおける関節軟骨に対するT1rho MRIの診断意義

  橋本 慎吾, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Goto Hajimu, 岩間 雄基, 藤井 正彦, 西山 隆之, Kurosaka Masahiro

  5th Annual Meeting of Japanese Orthopaedic Society of Knee,Arthroscopy and Sports Medicine, Jun. 2013, Japanese, Japanese Orthopaedic Society of Knee,Arthroscopy and Sports Medicine, 札幌, Domestic conference

  Oral presentation


• 変形性股関節症に対するChiari骨盤骨切り術の長期成績

  西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, Kurosaka Masahiro

  The 86th Annual Meeting of the Japanese Orthopaedic Association, May 2013, Japanese, The Japanese Orthopaedic Association, 広島, Domestic conference

  Oral presentation


• 人工股関節術後でのエドキサバン投与の有効性と安全性

  橋本 慎吾, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, 神埼 至幸, 佐々木 宏, 柴沼 均, Kurosaka Masahiro

  The 86th Annual Meeting of the Japanese Orthopaedic Association, May 2013, Japanese, The Japanese Orthopaedic Association, 広島, Domestic conference

  Poster presentation


• PTEN regulates the expressions of typeII collagen and aggrecan under oxidative stress in human chondrocytes

  岩佐 賢二郎, Hayashi Shinya, Fujishiro Takaaki, Kanzaki Noriyuki, 橋本 慎吾, 川北 晃平, 鎮西 伸顕, 坂田 周平, Kuroda Ryosuke, Kurosaka Masahiro

  The 2013 Annual meeting of osteoarthritis research international, Apr. 2013, English, osteoarthritis research international, Philadelphia, USA, International conference

  Poster presentation


• p21 regulates MMP-13 expression via STAT3 signaling in chondrocytes.

  Hayashi Shinya, Shuhei Sakata, Takayuki Nishiyama, Fujishiro Takaaki, Kanzaki Noriyuki, Kohei Kawakita, Kenjiro Iwasa, Kuroda Ryosuke, Kurosaka Masahiro

  The Annual Meeting of 2013 Osteoarthritis Research Society International, Apr. 2013, English, The Osteoarthritis Research Society International, Philadelphia, USA, International conference

  Oral presentation


• Eicosapentaenoic acid reduced chondrocytes apoptosis by oxidative stress

  Shuhei Sakata, Hayashi Shinya, Fujishiro Takaaki, Kanzaki Noriyuki, Shingo Hashimoto, Kohei Kawakita, Nobuaki Chinzei, Kenjiro Iwasa, Kuroda Ryosuke, Kurosaka Masahiro

  The 2013 Annual meeting of osteoarthritis research international, Apr. 2013, English, osteoarthritis research international, Philadelphia, USA, International conference

  Oral presentation


• エイコサペンタエン酸は酸化ストレス依存性の軟骨細胞のアポトーシス

  坂田 周平, Hayashi Shinya, Fujishiro Takaaki, Kanzaki Noriyuki, 橋本 慎吾, 川北 晃平, 岩佐 賢二郎, 鎮西 伸顕, Kuroda Ryosuke, Kurosaka Masahiro

  第26回日本軟骨代謝学会, Mar. 2013, Japanese, 日本軟骨代謝学会, 大阪, エイコサペンタエン酸は、軟骨細胞変性、アポトーシスを抑制し、変形性関節症治療に有用である可能性がある, Domestic conference

  Oral presentation


• 人工股関節置換術後患者におけるエドキサバン投与の有用性と安全性

  橋本 慎吾, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 柴沼 均, 西山 隆之, Kurosaka Masahiro

  第43回日本人工関節学会, Feb. 2013, Japanese, 日本人工関節学会, 京都, 人工股関節全置換術症例におけるエドキサバンのDVT予防効果を報告した。, Domestic conference

  Oral presentation


• 運動誘発電位モニタリングを併用した人工股関節再置換術

  Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, 川北 晃平, 岩佐 賢二郎, 坂田 周平, 鎮西 伸顕, Kurosaka Masahiro, 西山 隆之

  第43回日本人工関節学会, Feb. 2013, Japanese, 日本人工関節学会, 京都, 運動誘発電位モニタリングを併用した人工股関節再置換術を検討した, Domestic conference

  Poster presentation


• ヒト軟骨細胞においてPTENは酸化ストレス下でII型コラーゲンとアグリカンの発現を調整する

  岩佐 賢二郎, Hayashi Shinya, Fujishiro Takaaki, 川北 晃平, Kanzaki Noriyuki, 橋本 慎吾, 鎮西 伸顕, 坂田 周平, Kurosaka Masahiro

  第26回軟骨代謝学会, Feb. 2013, Japanese, 軟骨代謝学会, 大阪, PTENはメカニカルストレス存在下に軟骨基質産生を調節する。, Domestic conference

  Oral presentation


• CT based fluoroscopic matching navigation systemを使用したTHAの大腿骨コンポーネント設置角度の精度分析

  Hayashi Shinya, 西山 隆之, Fujishiro Takaaki, 橋本 慎吾, Kanzaki Noriyuki, 坂田 周平, 川北 晃平, 鎮西 伸顕, 岩佐 賢二郎, Kurosaka Masahiro

  第43回日本人工関節学会, Feb. 2013, Japanese, 日本人工関節学会, 京都, CT based fluoroscopic matching navigation system を使用したTHAの大腿骨コンポーネント設置角度, Domestic conference

  Oral presentation


• p21 regulates MMP-13 expression via STAT3signaling in chondrocytes

  Hayashi Shinya, Takayuki Nishiyama, Fujishiro Takaaki, Shingo Hashimoto, Shuhei Sakata, Kenjiro Iwasa, Kohei Kawakita, Nobuaki Chinzei, Kanzaki Noriyuki, Kuroda Ryosuke, Kurosaka Masahiro

  59th Annual Meeting of the Orthopaedic Research Society, Jan. 2013, English, OrthopaedicResearch Society, San Antonio, メカニカルストレス応答性にp21cip1はMMP13の発現を調節する, International conference

  Poster presentation


• AKT Phosphrylation in Human Chondrocytes is Regulatedby P53R3 In Response to Mechanical Stress

  Kohei Kawakita, Takayuki Nishiyama, Fujishiro Takaaki, Hayashi Shinya, Shingo Hashimoto, Kanzaki Noriyuki, Kenjiro Iwasa, Shuhei Sakata, Kurosaka Masahiro

  59th Annual Meeting of the Orthopaedic Research Society, Jan. 2013, English, Orthopaedic Research Society, San Antonio, p53R2はメカニカルストレス存在下でAKTを介して基質産生を調節する。, International conference

  Poster presentation


• 変形性股関節症患者の運動療法介入前後におけるHealth related quality of life 評価～メンタルヘルスに着目して～

  伊良皆 仁美, Uesugi Yuko, 谷口 早紀, Hayashi Shinya, 橋本 慎吾, 山口 良太, Fujishiro Takaaki, 西山 隆之

  第39回日本股関節学会学術集会, Dec. 2012, Japanese, 日本股関節学会学術集会, 新潟, 変形性股関節症患者の運動療法介入前後におけるHealth related quality of life 評価, Domestic conference

  Poster presentation


• 変形性股関節症患者の運動療法介入におけるセルフエフィカシーの変化

  谷口 早紀, Uesugi Yuko, 伊良皆 仁美, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, 山口 良太, 西山 隆之

  第39回日本股関節学会学術集会, Dec. 2012, Japanese, 日本股関節学会学術集会, 新潟, 変形性股関節症患者の運動療法介入におけるセルフエフィカシーの変化を検討した, Domestic conference

  Oral presentation


• 肥満とインプラントインピンジメントとの関係

  Hayashi Shinya, 西山 隆之, Fujishiro Takaaki, 橋本 慎吾, Kanzaki Noriyuki, 川北 晃平, 岩佐 賢二郎, 坂田 周平, 鎮西 伸顕, Kurosaka Masahiro

  第39回日本股関節学会学術集会, Dec. 2012, Japanese, 日本股関節学会学術集会, 新潟, 肥満とインプラントインピンジメントとの関係, Domestic conference

  Oral presentation


• 前・初期股関節症に対するChiari骨盤骨切り術の術後成績

  西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, Kurosaka Masahiro

  第39回日本股関節学会学術集会, Dec. 2012, Japanese, 日本股関節学会学術集会, 新潟, 前・初期股関節症に対するChiari骨盤骨切り術の術後成績を検討した。, Domestic conference

  Oral presentation


• 人工股関節置換術後でのエドキサバン投与の有用性と安全性

  橋本 慎吾, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 柴沼 均, Kurosaka Masahiro

  第39回日本股関節学会学術集会, Dec. 2012, Japanese, 日本股関節学会学術集会, 新潟, 人工股関節全置換術症例におけるエドキサバンのDVT予防効果を報告した。, Domestic conference

  Oral presentation


• 人工股関節全置換術症例におけるレントゲン学的FAIの存在

  橋本 慎吾, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 川北 晃平, 岩佐 賢二郎, 坂田 周平, 鎮西 伸顕, Kurosaka Masahiro

  第39回日本股関節学会学術集会, Dec. 2012, Japanese, 日本股関節学会学術集会, 新潟, 人工股関節全置換術症例におけるレントゲン学的FAIの存在頻度を検討した。, Domestic conference

  Oral presentation


• 人工股関節の可動域に対する大腿骨オフセットの影響

  西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, Kurosaka Masahiro

  第39回日本股関節学会学術集会, Dec. 2012, Japanese, 日本股関節学会学術集会, 新潟, 人工股関節の可動域に対する大腿骨オフセットの影響を検討した。, Domestic conference

  Oral presentation


• 股関節評価はどう変わるのか

  Uesugi Yuko, 伊藤 都, 中村 宣雄, 西山 隆之, 西井 孝, 坂井 孝司, 高尾 正樹, Fujishiro Takaaki, Hayashi Shinya, 菅野 伸彦

  第39回日本股関節学会学術集会, Dec. 2012, Japanese, 日本股関節学会学術集会, 新潟, 新しい股関節評価を検討した。, Domestic conference

  [Invited]

  Nominated symposium


• ナビゲーションを用いたTHAセメントレスソケットのスクリュー固定前後での角度変化

  Fujishiro Takaaki, 西山 隆之, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, 川北 晃平, 岩佐 賢二郎, 坂田 周平, 鎮西 伸顕, Kurosaka Masahiro

  第39回日本股関節学会, Dec. 2012, Japanese, 日本股関節学会, 新潟, スクリュー固定によるカップの変化を検討, Domestic conference

  Oral presentation


• CT based fluoroscopic matching navigation system を使用したTHAの大腿骨コンポーネント設置角度

  Hayashi Shinya, 西山 隆之, Fujishiro Takaaki, 橋本 慎吾, 川北 晃平, 岩佐 賢二郎, 坂田 周平, Kanzaki Noriyuki, 鎮西 伸顕, Kurosaka Masahiro

  第39回日本股関節学会学術集会, Dec. 2012, Japanese, 日本股関節学会学術集会, 新潟, CT based fluoroscopic matching navigation system を使用したTHAの大腿骨コンポーネント設置角度, Domestic conference

  Oral presentation


• ヒト軟骨細胞においてPTENはtype II collagenの発現を制御する

  岩佐 賢二郎, 西山 隆之, Hayashi Shinya, Fujishiro Takaaki, 川北 晃平, Kanzaki Noriyuki, 橋本 慎吾, 坂田 周平, Kuroda Ryosuke, Kurosaka Masahiro

  The 27th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2012, Japanese, The Japanese Orthopaedic Association, 名古屋, PTENはメカニカルストレス存在下に軟骨基質産生を調節する。, Domestic conference

  Poster presentation


• Evaluation of acetabular component alignment change during screw fixation using navigation system

  Fujishiro Takaaki, Takayuki Nishiyama, Hayashi Shinya, Shingo Hashimoto, Nao Shibanuma, Kurosaka Masahiro

  25th Annual Meeting of International Society for Technology in Arthroplasy, Oct. 2012, English, Annual Meeting of International Society for Technology in Arthroplasy, シドニー, スクリュー固定によるカップの変化を検討, International conference

  Poster presentation


• Evaluation of acetabular component alignment change during screw fixation using navigation system

  Fujishiro Takaaki, Takayuki Nishiyama, Hayashi Shinya, Shingo Hashimoto, Nao Shibanuma, Kurosaka Masahiro

  12th Annual Meeting of International Society for Computer Assisted Orthopaedic Surgery, Jun. 2012, English, Annual Meeting of International Society for Computer Assisted Orthopaedic Surgery, ソウル, スクリュー固定によるカップの変化を検討, International conference

  Oral presentation


• Kerboull型プレートを用いた人工股関節再置換術の術後

  西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, 川北 晃平, 岩佐 賢二郎, 坂田 周平, Kurosaka Masahiro

  The 85th Annual Meeting of the Japanese Orthopaedic Assosiation, May 2012, Japanese, The Japanese Orthopaedic Association, 京都, Kerboull型プレートを用いた人工股関節再置換術の術後を検討した。, Domestic conference

  Oral presentation


• 関節リウマチ患者の胃食道逆流症(GERD)に関する検討

  MIURA YASUSHI, 福田 康治, 前田 俊恒, HAYASHI SHINYA, KUROSAKA MASAHIRO

  第56回日本リウマチ学会, Apr. 2012, Japanese, 京都, Domestic conference

  Oral presentation


• リウマチ患者における音楽療法の有用性の検討

  MIURA YASUSHI, 松尾 絹絵, 福田 康治, 前田 俊恒, HAYASHI SHINYA, KUROSAKA MASAHIRO, 山崎 郁子

  第56回日本リウマチ学会, Apr. 2012, Japanese, 京都, Domestic conference

  Oral presentation


• p21 regulates MMP-13 expression and decreased aggrecan expression via STAT3/ SDF-1 pathway.

  Hayashi Shinya, 西山 隆之, Fujishiro Takaaki, 橋本 慎吾, 岩佐 賢二郎, 川北 晃平, 坂田 周平, Kuroda Ryosuke, Kurosaka Masahiro

  Annual meeting of osteoarthritis research international, Apr. 2012, English, Annual meeting of osteoarthritis research international, バルセロナ, メカニカルストレス応答性にp21cip1はMMP13の発現を調節する, International conference

  Poster presentation


• Clinical trial of step-up exercise therapy using DVD for patients with hip osteoarthritis.

  UESUGI YUKO, 小柳 淳一郎, 西井 孝, HAYASHI SHINYA, FUJISHIRO TAKAAKI, 高木 啓至, 山口 良太, NISHIYAMA TAKAYUKI

  Osteoarthritis Research Society International, Apr. 2012, English, International conference

  Oral presentation


• 軟骨細胞におけるAktのリン酸化はメカニカルストレスで生じるp53R2により制御される

  川北 晃平, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 武部 健, 岩佐 賢二郎, Kurosaka Masahiro

  第25回日本軟骨代謝学会, Mar. 2012, Japanese, 日本軟骨代謝学会, 名古屋, Domestic conference

  Oral presentation


• メカニカルストレス応答性にp21cip1はMMP13の発現を調節する

  Hayashi Shinya, 西山 隆之, Fujishiro Takaaki, 橋本 慎吾, 岩佐 賢二郎, 川北 晃平, 坂田 周平, Kurosaka Masahiro

  第26回日本軟骨代謝学会, Mar. 2012, Japanese, 日本軟骨代謝学会, 名古屋, Domestic conference

  Others


• メカニカルストレス応答性にp21cip1はMMP13の発現を調節する

  Hayashi Shinya, 西山 隆之, Fujishiro Takaaki, 橋本 慎吾, 岩佐 賢二郎, 川北 晃平, 坂田 周平, Kuroda Ryosuke, Kurosaka Masahiro

  第25回日本軟骨代謝学会, Mar. 2012, Japanese, 日本軟骨代謝学会, 名古屋, メカニカルストレス応答性にp21cip1はMMP13の発現を調節する, Domestic conference

  Oral presentation


• ヒト軟骨細胞においてPTENはtype II collagenの発現を調整する

  岩佐 賢二郎, 西山 隆之, Hayashi Shinya, Fujishiro Takaaki, 橋本 慎吾, 川北 晃平, 坂田 周平, Kurosaka Masahiro

  第25回日本軟骨代謝学会, Mar. 2012, Japanese, 日本軟骨代謝学会, 名古屋, Domestic conference

  Oral presentation


• ナビゲーションを用いたTHAセメントレスソケットの角度計測の精度評価と臨床評価

  Fujishiro Takaaki, 西山 隆之, Hayashi Shinya, 橋本 慎吾, 川北 晃平, 岩佐 賢二郎, 坂田 周平, Kurosaka Masahiro

  第42回日本人工関節学会, Feb. 2012, Japanese, 日本人工関節学会, 沖縄, Domestic conference

  Oral presentation


• トリプルテーパーステム使用THAの術後ステム周囲骨密度と活動性との相関.

  Hayashi Shinya, 西山 隆之, Fujishiro Takaaki, 橋本 慎吾, 川北 晃平, 岩佐 賢二郎, 坂田 周平, Kurosaka Masahiro

  第42回日本人工関節学会, Feb. 2012, Japanese, 日本人工関節学会, 沖縄, Domestic conference

  Oral presentation


• Hybrid型人工股関節全置換術の10年以上の成績（大腿骨側セメンティング手技の影響の検討）

  西山 隆之, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, 川北 晃平, 岩佐 賢二郎, 坂田 周平, Kurosaka Masahiro

  第42回日本人工関節学会, Feb. 2012, Japanese, 日本人工関節学会, 沖縄, Domestic conference

  Oral presentation


• Expression of p53R2 in chondrocytes is regulated by mechanical stress.

  Kawakita Kohei, Nishiyama Takayuki, Fujishiro Takaaki, Hayashi Shinya, Hashimoto S, Takebe K, Iwasa K, Sakata S, Kurosaka Masahiro

  2011 Annual Meeting of the Orthopaedic Research Society, Feb. 2012, English, the Orthopaedic Research Society, サンフランシスコ, アメリカ, International conference

  Poster presentation


• 人工股関節イメージマッチングとその課題

  Hayashi Shinya, 西山 隆之, Fujishiro Takaaki, Kanzaki Noriyuki, 橋本 慎吾, 武部 健, Akisue Toshihiro, Kurosaka Masahiro

  第38回日本臨床バイオメカニクス学会, Nov. 2011, Japanese, 日本臨床バイオメカニクス学会, 神戸, Domestic conference

  Others


• Mechanical stress increased p21cip1 expression in chondrocytes

  Hayashi Shinya, Nishiyama Takashi, Iwasa K, Fujishiro Takaaki, Kanzaki Noriyuki, Kawakita K, Kuroda Ryosuke, Kurosaka Masahiro

  2011 World Congress on Osteoarthritis, Nov. 2011, English, Osteoarthritis reseand Society International, サンディエゴ, アメリカ, International conference

  Poster presentation


• Expression of p53R2 in chondrocytes is regulated by mechanical stress

  Kawakita K, Nishiyama Takashi, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Takebe K, Iwasa K, Sakata S, Kurosaka Masahiro

  2011 World Congress on Osteoarthritis, Nov. 2011, English, Osteoarthritis reseand Society International, サンディエゴ, アメリカ, International conference

  Poster presentation


• 末期股関節症に対するChiari骨盤骨切り術の治療成績

  西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, 川北 晃平, 岩佐 賢二郎, 坂田 周平, 三枝 康宏, Kurosaka Masahiro

  第38回日本股関節学会, Oct. 2011, Japanese, 日本股関節学会, 鹿児島, Domestic conference

  Others


• 軟骨細胞におけるp53R2の発現はメカニカルストレスにより制御される

  川北 晃平, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 武部 建, 岩佐 賢二郎, 坂田 周平, Kurosaka Masahiro

  第26回日本整形外科学会基礎学術集会, Oct. 2011, Japanese, 日本整形外科学会, 群馬, Domestic conference

  Poster presentation


• 骨盤3次元CT画像を用いた骨盤座標系の自動決定法の検証

  Fujishiro Takaaki, 西山 隆之, Hayashi Shinya, Kanzaki Noriyuki, 武部 健, 川北 晃平, 岩佐 賢二郎, 坂田 周平, Kurosaka Masahiro, 柴沼 均

  第38回日本股関節学会, Oct. 2011, Japanese, 日本股関節学会, 鹿児島, Domestic conference

  Oral presentation


• 一側偏心性寛骨臼回転骨切り術後、9ヶ月に対側同手術を施行された患者における歩容変化

  山口 良太, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 武部 健

  第38回日本股関節学会, Oct. 2011, Japanese, 日本股関節学会, 鹿児島, Domestic conference

  Poster presentation


• ナビゲーションを用いたTHAセメントレスソケットのスクリュー固定前後での角度変化の評価

  Fujishiro Takaaki, 西山 隆之, Hayashi Shinya, Kanzaki Noriyuki, 武部 健, 川北 晃平, 岩佐 賢二郎, 坂田 周平, Kurosaka Masahiro

  第38回日本股関節学会, Oct. 2011, Japanese, 日本股関節学会, 鹿児島, Domestic conference

  Oral presentation


• RA股関節に対するSupport ringを用いた人工股関節置換術の成績

  西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, 武部 健, 川北 晃平, 岩佐 賢二郎, 坂田 周平, Kurosaka Masahiro

  第38回日本股関節学会, Oct. 2011, Japanese, 日本股関節学会, 鹿児島, Domestic conference

  Others


• G2ステム使用THAの術後ステム周囲骨密度と活動性との相関

  Hayashi Shinya, 西山 隆之, Fujishiro Takaaki, Kanzaki Noriyuki, 武部 健, 川北 晃平, 岩佐 賢二郎, 坂田 周平, Kurosaka Masahiro

  第38回日本股関節学会, Oct. 2011, Japanese, 日本股関節学会, 鹿児島, Domestic conference

  Oral presentation


• ibialis spastic varus foot without tarsal coalition: a report of two cases

  Kanzaki Noriyuki, Nishiyama Takashi, Fujishiro Takaaki, Hayashi Shinya, Takebe K, Matsumoto A, Shibanuma N, Takakura Y, Kurosaka Masahiro

  第36回日本足の外科学会, Sep. 2011, Japanese, 日本足の外科学会, 奈良, Domestic conference

  Oral presentation


• MDCT画像を用いた骨盤座標系の自動決定法

  Fujishiro Takaaki, 西山 隆之, Hayashi Shinya, Kanzaki Noriyuki, 武部 健, 川北 晃平, 岩佐 賢二郎, Kurosaka Masahiro, 柴沼 均, 藤本 聡史, 小橋 昌司, 畑 豊

  第5回日本CAOS研究会, Sep. 2011, Japanese, 大阪市立大学, 大阪, Domestic conference

  Oral presentation


• Leg length change in total hip arthroplasty with subtrochanteric femoral shortening osteotomy for Crowe type IV developmental hip dysplasia

  Fujishiro Takaaki, Nishiyama Takashi, Hayashi Shinya, Kanzaki Noriyuki, Takebe K, Kurosaka Masahiro

  At the 24th Annual Meeting of International Society for Technology in Arthroplasy, Sep. 2011, English, International Society for Technology in Arthroplasy, ブルージュ, ベルギー, International conference

  Oral presentation


• 前初期股関節症に対する大腿骨転子間内反骨切り術の長期成績

  西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, 武部 健, 川北 晃平, 岩佐 賢二郎, 三枝 康宏, Kurosaka Masahiro

  第84回日本整形外科学会学術総会, May 2011, Japanese, 日本整形外科学会, 横浜, Domestic conference

  Oral presentation


• G2 stem 使用後THAではstem周囲の骨密度が温存される

  Hayashi Shinya, 西山 隆之, Fujishiro Takaaki, Kanzaki Noriyuki, 武部 健, 川北 晃平, 岩佐 賢二郎, Kurosaka Masahiro

  第84回日本整形外科学会学術総会, May 2011, Japanese, 日本整形外科学会, 横浜, Domestic conference

  Oral presentation


• 人工股関節全置換術後にフォンダパリヌクスを使用した症例の検討～1.5mgと2.5mgについての前向き調査～

  Kanzaki Noriyuki, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, 武部 健, 川北 晃平, 岩佐 賢二郎, Kurosaka Masahiro

  第116回中部日本整形災害外科学会, Apr. 2011, Japanese, 中部日本整形災害外科学会, 高知, Domestic conference

  Oral presentation


• 大腿骨頭径による人工股関節全置換術の術後成績の違い

  西山 隆之, 武部 健, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 川北 晃平, 岩佐 賢二郎, Kurosaka Masahiro

  第30回整形外科バイオマテリアル研究会, Dec. 2010, Japanese, 整形外科バイオマテリアル研究会, 京都, Domestic conference

  Oral presentation


• metal on metal型人工股関節全置換術における短期成績-

  武部 健, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 川北 晃平, 岩佐 賢二郎, Kurosaka Masahiro

  第38回日本関節病学会, Nov. 2010, Japanese, 日本関節病学会, 京都, Domestic conference

  Oral presentation


• 人工股関節全置換術後にフォンダパリヌクスを使用した症例の検討～1.5mgと2.5mgについての前向き調査～

  Kanzaki Noriyuki, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, 武部健, 川北 晃平, Kurosaka Masahiro

  第37回日本股関節学会, Oct. 2010, Japanese, 日本股関節学会, 福岡, Domestic conference

  Oral presentation


• 後方アプローチによるTHA術後の脱臼とその方向は予測可能か?―CT画像を用いたソケットとステムの設置角度の検討―

  Fujishiro Takaaki, 西山 隆之, Hayashi Shinya, 武部 健, 川北晃平, 岩佐 賢二郎, Kurosaka Masahiro, 増田 武志, 菅野 大己

  第37回日本股関節学会, Oct. 2010, Japanese, 日本股関節学会, 福岡, Domestic conference

  Public symposium


• 温熱ストレスによる軟骨細胞アポトーシスにおけるp38のリン酸化の関与

  武部 健, 西山 隆之, Hayashi Shinya, 橋本 慎吾, Fujishiro Takaaki, Kanzaki Noriyuki, 川北 晃平, Kuroda Ryosuke, Kurosaka Masahiro

  第25回日本整形外科学会基礎学術集会, Oct. 2010, Japanese, 日本整形外科学会, 京都, Domestic conference

  Oral presentation


• タナ形成術を併用した大腿骨転子間内反骨切り術の長期成績

  西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 武部 健, 川北 晃平, 岩佐 賢二郎, Kurosaka Masahiro

  第37回日本股関節学会, Oct. 2010, Japanese, 日本股関節学会, 福岡, Domestic conference

  Oral presentation


• p53R2の発現はメカニカルストレスにより制御される－OA治療への可能性

  川北晃平, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 武部 健, 岩佐賢二郎, Kurosaka Masahiro

  第25回日本整形外科学会基礎学術集会, Oct. 2010, Japanese, 日本整形外科学会, 京都, Domestic conference

  Poster presentation


• metal on metal型人工股関節全置換術における経時的成績-ADLとROM-

  武部 健, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 川北 晃平, 岩佐 賢二郎, 鈴木 祥浩, Kurosaka Masahiro

  第37回日本股関節学会, Oct. 2010, Japanese, 日本股関節学会, 福岡, Domestic conference

  Poster presentation


• Involvement of p38 MAP kinase phosphorylation in chondrocyte apoptosis induced by heat stress.

  Takebe K, Nishiyama Takashi, Hayashi Shinya, Hashimoto S, Fujishiro Takaaki, Kanzaki Noriyuki, Kawakita K, Iwasa K, Kuroda Ryosuke, Kurosaka Masahiro

  7th Combined meeting of the orthopaedic research societies, Oct. 2010, English, 日本整形外科学会, 京都, International conference

  Poster presentation


• G2 stem 使用THA後のstem周囲の骨密度変化

  Hayashi Shinya, 西山 隆之, Fujishiro Takaaki, Kanzaki Noriyuki, 武部 健, 川北 晃平, 岩佐 賢二郎, Kurosaka Masahiro

  第37回日本股関節学会, Oct. 2010, Japanese, 日本股関節学会, 福岡, Domestic conference

  Oral presentation


• p53R2 in chondrocytes is up-regulated by mechanical stress

  Kawakita K, Nishiyama Takashi, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Takebe K, Iwasa K, Kurosaka Masahiro

  2010 World congress on osteoarthritis, Sep. 2010, English, 世界変形性関節症学会, ブリュッセル, ベルギー, International conference

  Poster presentation


• Involvement of p38 MAP kinase phosphorylation in chondrocytes apoptosis induced by heat stress

  Takebe K, Nishiyama Takashi, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Kawakita K, Iwasa K, Kurosaka Masahiro

  2010 World congress on osteoarthritis, Sep. 2010, English, 世界変形性関節症学会, ブリュッセル, ベルギー, International conference

  Poster presentation


• 足舟状骨偽関節に伴う距舟関節症の1例

  Kanzaki Noriyuki, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, 武部 健, 川北 晃平, 岩佐 賢二郎, Kurosaka Masahiro

  第35回日本足の外科学会学術集会, Jun. 2010, Japanese, 日本足の外科学会, 奈良, Domestic conference

  Poster presentation


• 前初期股関節症に対する臼蓋形成術の成績

  西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 武部 健, 川北 晃平, Kurosaka Masahiro

  第83回日本整形外科学会学術総会, May 2010, Japanese, 日本整形外科学会, 東京, Domestic conference

  Oral presentation


• 温熱ストレスによる軟骨細胞アポトーシスにおけるp38のリン酸化の関与

  武部 健, 西山 隆之, Hayashi Shinya, 橋本 慎吾, Fujishiro Takaaki, Kanzaki Noriyuki, 川北 晃平, Kuroda Ryosuke, Kurosaka Masahiro

  第23回日本軟骨代謝学会, Apr. 2010, Japanese, 日本軟骨代謝学会, 鹿児島, Domestic conference

  Oral presentation


• p53R2の発現はメカニカルストレスにより制御される－OA治療への可能性

  川北 晃平, Hayashi Shinya, 西山 隆之, Fujishiro Takaaki, Kanzaki Noriyuki, 武部 健, Kurosaka Masahiro

  第23回日本軟骨代謝学会, Apr. 2010, Japanese, 日本軟骨代謝学会, 鹿児島, Domestic conference

  Oral presentation


• Long term results of intertrochanteric varus osteotomy for the dysplastic hip

  Nishiyama Takashi, Saegusa Y, Fujishiro Takaaki, Kanzaki Noriyuki, Hayashi Shinya, Kurosaka Masahiro

  2010 AAOS Annual meeting., Mar. 2010, English, AAOS Annual meeting., ニューオリンズ, アメリカ, International conference

  Poster presentation


• Autocrine Motility Factor Regulates the Cell Survival in Human Chondrocytes

  Shingo Hashimoto, Takayuki Nishiyama, Hayashi Shinya, Fujishiro Takaaki, Kanzaki Noriyuki, Ken Takebe, Kohei Kawakita, Kuroda Ryosuke, Kurosaka Masahiro

  56th Annual Meeting of the Orthopaedic Research Society, Mar. 2010, English, Orthopaedic Research Society, ニューオリンズ, アメリカ, International conference

  Poster presentation


• 人工股関節全置換術時の大腿骨の引き下げ量は予測可能か?

  Fujishiro Takaaki, 西山 隆之, Hayashi Shinya, 武部 健, 川北晃平, Kurosaka Masahiro, 増田 武志, 菅野 大己

  第40回日本人工関節学会, Feb. 2010, Japanese, 日本人工関節学会, 沖縄, Domestic conference

  Public symposium


• 人工股関節全置換術後にフォンダパリニクス（1.5mg/2.5mg）を使用した症例の検討〜D-ダイマーを指標として〜

  Kanzaki Noriyuki, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, 武部 健, 川北 晃平, Kurosaka Masahiro

  第40回日本人工関節学会, Feb. 2010, Japanese, 日本人工関節学会, 沖縄, Domestic conference

  Oral presentation


• metal on metal型人工股関節全置換術における短期成績-大腿骨頭径による比較-

  武部 健, 西山隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 川北晃平, Kurosaka Masahiro

  第40回日本人工関節学会, Feb. 2010, Japanese, 日本人工関節学会, 沖縄, Domestic conference

  Poster presentation


• 変形性股関節症に対する臼蓋形成術後の10年以上の成績

  西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, 武部 健, 川北 晃平, Kurosaka Masahiro

  第36回日本股関節学会, Oct. 2009, Japanese, 日本股関節学会, 京都, Domestic conference

  Oral presentation


• 前初期股関節症に対する内反骨切り術の長期成績

  西山 隆之, 三枝 康宏, Fujishiro Takaaki, Kanzaki Noriyuki, Hayashi Shinya, Kurosaka Masahiro

  第113回中部日本整形外科災害外科学会学術集会, Oct. 2009, Japanese, 中部日本整形外科災害外科学会, 神戸, Domestic conference

  Oral presentation


• 人工股関節全置換術後にフォンダパリニクスを使用した症例の検討―D-ダイマーを指標として

  Kanzaki Noriyuki, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, 武部 健, 川北 晃平, Kurosaka Masahiro

  第36回日本股関節学会, Oct. 2009, Japanese, 日本股関節学会, 京都, Domestic conference

  Oral presentation


• 人工股関節全置換術後にフォンダパリニクスを使用した症例の検討―D-ダイマーを指標として

  Kanzaki Noriyuki, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, Kurosaka Masahiro

  第113回中部日本整形外科災害外科学会学術集会, Oct. 2009, Japanese, 中部日本整形外科災害外科学会, 神戸, Domestic conference

  Oral presentation


• 軟骨細胞における温熱刺激によるp53 経路を介したアポトーシス

  Nishiyama Takayuki, Fujishiro Takaaki, Hayashi Shinya, Kuroda Ryosuke, Kurosaka Masahiro

  第22回日本軟骨代謝学会, Mar. 2009, Japanese, 日本軟骨代謝学会, 名古屋, Domestic conference

  Poster presentation


• ヒト正常軟骨細胞におけるAMF のアポトーシス制御

  Nishiyama Takayuki, Hayashi Shinya, Fujishiro Takaaki, Kuroda Ryosuke, Kurosaka Masahiro

  第22回日本軟骨代謝学会, Mar. 2009, Japanese, 日本軟骨代謝学会, 名古屋, Domestic conference

  Oral presentation


• Overexpression of Autocrine motility factor induces the resistance against apoptosis in human chondrocytes

  Shingo Hashimoto, Nishiyama Takayuki, Hayashi Shinya, Fujishiro Takaaki, Noriyuki Kanzaki, Ken Takebe, Kuroda Ryosuke, Kurosaka Masahiro

  55th Annual Meeting of the Orthopaedic Research Society, Feb. 2009, English, Orthopaedic Research Society, ラスベガス, アメリカ, International conference

  Poster presentation


• 長寿因子SIRT１はヒト軟骨細胞のアポトーシスを抑制する

  Kuroda Ryosuke, Matsushita Takehiko, Kubo Seiji, Hayashi Shinya, Matsumoto Tomoyuki, Kinoshita Keisuke, Kurosaka Masahiro

  第23回日本整形外科学会基礎学術集会, Oct. 2008, Japanese, 日本整形外科学会, 京都, Domestic conference

  Oral presentation


• 引っ張り刺激によるヒト軟骨細胞のアポトーシスとp53の関連

  橋本慎吾, Nishiyama Takayuki, Hayashi Shinya, Fujishiro Takaaki, 武部 健, 鈴木祥浩, 神崎至幸, Kuroda Ryosuke, Kurosaka Masahiro

  第23回日本整形外科学会基礎学術集会, Oct. 2008, Japanese, 日本整形外科学会, 京都, Domestic conference

  Oral presentation


• リウマチ滑膜腺維芽細胞に対するＤｃＲ３のリガンド作用の検討

  Miura Yasushi, Hayashi Shinya, Sakai Yoshitada, Kurosaka Masahiro

  第23回日本整形外科学会基礎学術集会, Oct. 2008, Japanese, 日本整形外科学会, 京都, Domestic conference

  Oral presentation


• マクロファージ系細胞におけるデコイレセプターＤｃＲ３の機能解析

  Miura Yasushi, Hayashi Shinya, Sakai Yoshitada, Kurosaka Masahiro

  第23回日本整形外科学会基礎学術集会, Oct. 2008, Japanese, 日本整形外科学会, 京都, Domestic conference

  Oral presentation


• Autocrine motility factor induces the resistance against apoptosis in human chondrocytes

  Hashimoto Shotaro, Nishiyama Takayuki, Hayashi Shinya, Fujishiro Takaaki, Suzuki Yasuyuki, Kuroda Ryosuke, Kurosaka Masahiro

  2008 World congress on osteoarthritis, Sep. 2008, English, The Osteoarthritis Research Society International, ローマ, イタリア, International conference

  Poster presentation


• 関節リウマチ患者に対するインフリキシマブ時間短縮投与の試み

  Miura Yasushi, Sakai Yoshitada, Hayashi Shinya, Hashiramoto Akira, Shiozawa Shunichi, Kurosaka Masahiro

  第52回日本リウマチ学会総会, Apr. 2008, Japanese, 日本リウマチ学会, 札幌, Domestic conference

  Oral presentation


• リウマチ滑膜腺維芽細胞に対するＤｃＲ３の直接的作用の検討

  Miura Yasushi, Hayashi Shinya, Sakai Yoshitada, Shiozawa Shunichi, Kurosaka Masahiro

  第52回日本リウマチ学会総会, Apr. 2008, Japanese, 日本リウマチ学会, 札幌, Domestic conference

  Oral presentation


• マクロファージ系細胞におけるデコイレセプターＤｃＲ３の機能解析

  Miura Yasushi, Hayashi Shinya, Sakai Yoshitada, Shiozawa Shunichi, Kurosaka Masahiro

  第52回日本リウマチ学会総会, Apr. 2008, Japanese, 日本リウマチ学会, 札幌, Domestic conference

  Oral presentation


• ヒト正常軟骨細胞におけるAMFの機能解析

  Nishiyama Takayuki, Hayashi Shinya, Fujishiro Takaaki, Kuroda Ryosuke, Kurosaka Masahiro

  第21回日本軟骨代謝学会, Mar. 2008, Japanese, 日本軟骨代謝学会, 京都, Domestic conference

  Oral presentation


• Inhibition of p53 pathway reduced apoptosis of chondrocytes by shear stress

  Nishiyama Takayuki, Hayashi Shinya, Fujishiro Takaaki, Kuroda Ryosuke, Kurosaka Masahiro

  54thAnnualMeetingoftheOrthopaedicResearchSociety, Mar. 2008, English, The Orthopaedic Research Society, サンフランシスコ, アメリカ, International conference

  Oral presentation


• DcR3 induces cell proliferation through MAPK signaling in chondrocytes of osteoarthritis

  Hayashi Shinya, Nishiyama Takayuki, Miura Yasushi, Kuroda Ryosuke, Kurosaka Masahiro

  54thAnnualMeetingoftheOrthopaedicResearchSociety, Mar. 2008, English, The Orthopaedic Research Society, サンフランシスコ, アメリカ, International conference

  Oral presentation


• RAに対するFLステムを用いたTHAの短期成績

  Nishiyama Takayuki, Fujishiro Takaaki, Hayashi Shinya, Kurosaka Masahiro

  第38回日本人工関節学会, Feb. 2008, Japanese, 日本人工関節学会, 沖縄, Domestic conference

  Poster presentation


• p53 Inhibitor or ca suppress chondrocyte aportosis by shear stress

  Nishiyama Takayuki, Hayashi Shinya, Fujishiro Takaaki, Kuroda Ryosuke, Kurosaka Masahiro

  2007WorldCongressonOsteoarthritis, Dec. 2007, English, Osteoarthritis Research Society International, フロリダ, アメリカ, International conference

  Poster presentation


• p53 INHIBITOR CAN SUPPRESS CHONDROCYTE APOPTOSIS BY SHEAR STRESS

  Nishiyama Takayuki, Hayashi Shinya, Fujishiro Takaaki, Kuroda Ryosuke, Kurosaka Masahiro

  2007WorldCongressonOsteoarthritis, Dec. 2007, English, World Congress on Osteoarthritis, フロリダ, アメリカ, International conference

  Poster presentation


• Anxiety is correlated with clinical conditions of rheumatoid arthritis and improved by anti-TNF alpha therapy.

  Miura Yasushi, Hayashi Shinya, Shiozawa Shunichi, Kurosaka Masahiro

  第71回米国リウマチ学会, Nov. 2007, English, 米国リウマチ学会, ボストン, 米国, International conference

  Poster presentation


• Anxiety is correlated with clinical conditions of rheumatoid arthritis and improved by anti-TNF alpha therapy.

  Miura Yasushi, Sakai Yoshitada, Hayashi Shinya, Takahashi Motonori, Shiozawa Shunichi, Kurosaka Masahiro

  AmericanCollegeofRheumatology71stAnnualScientificMeeting, Nov. 2007, English, American College of Rheumatology, ボストン, アメリカ, International conference

  Oral presentation


• 前初期股関節症に対する内反骨切り術の長期成績（15年以上）

  Nishiyama Takayuki, Fujishiro Takaaki, Hayashi Shinya, Kurosaka Masahiro

  第34回日本股関節学会, Oct. 2007, Japanese, 日本股関節学会, 金沢, Domestic conference

  Public symposium


• 高齢者に対するFLステムを用いたTHAの短期成績

  Nishiyama Takayuki, Fujishiro Takaaki, Hayashi Shinya, Kurosaka Masahiro

  第34回日本股関節学会, Oct. 2007, Japanese, 日本股関節学会, 金沢, Domestic conference

  Poster presentation


• ヒト軟骨細胞を用いた引っ張り刺激（メカニカルストレス）によるアポトーシスとp53の関連

  Nishiyama Takayuki, Hayashi Shinya, Fujishiro Takaaki, Kurosaka Masahiro

  第22回日本整形外科学会基礎学術集会, Oct. 2007, Japanese, 日本整形外科学会, 浜松, Domestic conference

  Poster presentation


• SIRT1, longevity factor and class 3 histone deacetylase, regulates the apoptosis of human chondrocytes.

  Kuroda Ryosuke, Hayashi Shinya, Kubo Seiji, Kurosaka Masahiro

  7thInternationalCartilageRepairSociety, Sep. 2007, English, International Cartilage Repair Society, ワルシャワ, ポーランド, International conference

  Poster presentation


• Shear stress induced apoptosis of human chondrocytes via p53 pathway

  Hashimoto Shotaro, Nishiyama Takayuki, Hayashi Shinya, Fujishiro Takaaki, Suzuki Yasuyuki, Kuroda Ryosuke, Kurosaka Masahiro

  7thWorldCongressoftheInternationalCartilageRepairSociety, Sep. 2007, English, International Cartilage Repair Society, ワルシャワ, ポーランド, International conference

  Poster presentation


• Shear stress induced apoptosis of human chondrocytes via p53 pathway

  Nishiyama Takayuki, Hayashi Shinya, Fujishiro Takaaki, Kuroda Ryosuke, Kurosaka Masahiro

  7thInternationalCartilageRepairSociety, Sep. 2007, English, International Cartilage Repair Society, ワルシャワ, ポーランド, International conference

  Poster presentation


• Expression of Fas / FasL in the mouse chondrogenic ATDC5 cells

  Nishiyama Takayuki, Fujishiro Takaaki, Hayashi Shinya, Kurosaka Masahiro

  7thWorldCongressoftheInternationalCartilageRepairSociety, Sep. 2007, English, International Cartilage Repair Society, ワルシャワ, ポーランド, International conference

  Oral presentation


• The anxiety status and depressive symptoms were correlated with clinical conditions in Japanese patients with rheumatoid arthritis

  Miura Yasushi, Sakai Yoshitada, Hayashi Shinya, Hashiramoto Akira, Kurosaka Masahiro, Shiozawa Shunichi

  第２回東アジアリウマチ学会議, May 2007, English, 韓国リウマチ学会, ソウル, 韓国, International conference

  Oral presentation


• 生物製剤導入がリウマチ患者の不安と抑鬱状態に及ぼす影響

  Miura Yasushi, Sakai Yoshitada, Hayashi Shinya, Shiozawa Shunichi, Kurosaka Masahiro

  第51回日本リウマチ学会総会、学術集会, Apr. 2007, Japanese, 日本リウマチ学会, 横浜, Domestic conference

  Oral presentation


• 関節軟骨の変性を制御する因子

  Kuroda Ryosuke, Hayashi Shinya, Nishiyama Takayuki, Miura Yasushi, Sakai Yoshitada, Kurosaka Masahiro

  第51回日本リウマチ学会, Apr. 2007, Japanese, 日本リウマチ学会, 横浜, Domestic conference

  Public symposium


• 関節リウマチ患者における血清中DcR3濃度の解析 健常者との比較

  Hayashi Shinya, Miura Yasushi, Nishiyama Takayuki, Sakai Yoshitada, Shiozawa Shunichi, Kurosaka Masahiro

  第51回日本リウマチ学会総会、学術集会, Apr. 2007, Japanese, 日本リウマチ学会, 横浜, Domestic conference

  Oral presentation


• 関節リウマチ患者における血清中DcR3濃度の解析 健常者との比較

  Hayashi Shinya, Miura Yasushi, Nishiyama Takayuki, Sakai Yoshitada, Shiozawa Shunichi, Kurosaka Masahiro

  第５1回日本リウマチ学会学術総会・学術集会, Apr. 2007, Japanese, 有限責任中間法人日本リウマチ学会, 横浜, Domestic conference

  Oral presentation


• 関節リウマチ滑膜線維芽細胞におけるDEC-205の発現

  Miura Yasushi, Hayashi Shinya, Kurosaka Masahiro, Shiozawa Shunichi

  第51回日本リウマチ学会学術総会・学術集会, Apr. 2007, Japanese, 有限責任中間法人日本リウマチ学会, 横浜, Domestic conference

  Oral presentation


• レフルノミドとメソトレキサートを併用した関節リウマチ症例の検討

  Sakai Yoshitada, Miura Yasushi, Nishiyama Takayuki, Hayashi Shinya, Hashiramoto Akira, Shiozawa Shunichi, Kurosaka Masahiro

  第51回日本リウマチ学会総会、学術集会, Apr. 2007, Japanese, 日本リウマチ学会, 横浜, Domestic conference

  Poster presentation


• マクロファージ系細胞株におけるアポトーシス関連分子DcR3発現の検討

  Miura Yasushi, Hayashi Shinya, Sakai Yoshitada, Kurosaka Masahiro

  第51回日本リウマチ学会総会、学術集会, Apr. 2007, Japanese, 日本リウマチ学会, 横浜, Domestic conference

  Oral presentation


• マクロファージ系細胞株U937におけるアポトーシス関連分子DcR3発現の検討

  Miura Yasushi, Hayashi Shinya, Sakai Yoshitada, Shiozawa Shunichi, Kurosaka Masahiro

  第51回日本リウマチ学会総会、学術集会, Apr. 2007, Japanese, 日本リウマチ学会, 横浜, Domestic conference

  Oral presentation


• マクロファージ系細胞株U937におけるアポトーシス関連分子DcR3発現の検討

  Miura Yasushi, Hayashi Shinya, Sakai Yoshitada, Shiozawa Shunichi, Kurosaka Masahiro

  第51回日本リウマチ学会学術総会・学術集会, Apr. 2007, Japanese, 有限責任中間法人日本リウマチ学会, 横浜, Domestic conference

  Oral presentation


• HACA陽性となり減弱したインフリキシマブの効果がMTX増量により回復した関節リウマチの1症例

  Miura Yasushi, Sakai Yoshitada, Hayashi Shinya, Hashiramoto Akira, Kurosaka Masahiro, Shiozawa Shunichi

  第51回日本リウマチ学会総会、学術集会, Apr. 2007, Japanese, 日本リウマチ学会, 横浜, Domestic conference

  Oral presentation


• Angiopoietin-1は滑膜細胞上のVLA-5(α5β1インテグリン)を介してシグナル伝達する

  Miura Yasushi, Hayashi Shinya, Yoshida Kohsuke, Hashiramoto Akira, Kurosaka Masahiro, Shiozawa Shunichi

  第51回日本リウマチ学会学術総会・学術集会, Apr. 2007, Japanese, 有限責任中間法人日本リウマチ学会, 横浜, Domestic conference

  Oral presentation