Research activity information

• Nov. 2019 LASER THERAPY Prof. Ming-Chien Kao AWARD, New Development for Safer Endoscopic Submucosal Dissection using the Carbon Dioxide (CO2) Laser.


• Nov. 2018 日本レーザー医学会, 平成30年度日本レーザー医学会 論文賞, 消化器科領域の炭酸ガスレーザー～より安全な内視鏡的粘膜下層剥離術を目指した、炭酸ガスレーザーを用いた新たな展開～

  MORITA YOSHINORI

  Official journal


• Jan. 2018 神戸大学医学部第二内科同門会, 神戸大学医学部第二内科同門会助成金, ハイドロゲルを用いた新規内視鏡フードの開発

  Morita Yoshinori

  Others


• Dec. 2008 財団法人 内視鏡医学研究振興財団, NOTESにおけるsuturing deviceの開発, 平成20年度 内視鏡医学研究振興財団 研究助成B

  Morita Yoshinori


• Oct. 2008 財団法人 内視鏡医学研究振興財団, THE NEW APPROACH FOR THE DIFFICULT CASES IN EARLY GASTRIC CANCER TREATMENT- DEVELOPMENT OF DOUBLE SCOPE-ESD METHOD WITH “SPLIT BARREL”, 平成20年度 内視鏡医学研究医海外派遣助成

  Morita Yoshinori


• Jul. 2008 科学技術振興機構, 食道癌におけるMR内視鏡システムを用いた新たな診断法の開発, 平成20年度 科学技術振興機構 シーズ発掘試験 研究助成

  Morita Yoshinori


• Apr. 2007 文部科学省, 平成19年度 科学研究費 若手研究B, 早期胃癌に対する内視鏡的粘膜下層剥離術におけるナビゲーションシステムの開発

  MORITA YOSHINORI


• Oct. 2006 財団法人 内視鏡医学研究振興財団, 平成18年度 内視鏡医学研究医海外派遣助成, How can we overcome the difficult cases in early gastric cancer treatment with ESD method?:Challenging new technique with ゛Double scope-ESD ″

  MORITA YOSHINORI


• Jun. 2006 社団法人神緑会, 平成18年度 社団法人神緑会 研究助成, 早期消化管癌(食道・胃・大腸)の内視鏡治療におけるトレーニング手法及び医療機器開発について

  MORITA YOSHINORI


• Jan. 2006 財団法人 内視鏡医学研究振興財団, 平成１７年度 内視鏡医学研究振興財団 研究助成B, 早期胃癌に対するDouble scope-ESD (Endoscopic submucosal dissection)法の開発

  MORITA YOSHINORI

• Endoscopic submucosal dissection for severe fibrosis using a combined water pressure and circumferential-inversion method.

  Hiroshi Takayama, Toshitatsu Takao, Douglas Motomura, Hitomi Hori, Yoshinori Morita, Takashi Toyonaga, Yuzo Kodama

  Dec. 2024, Endoscopy, 56(S 01) (S 01), E35-E36, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Endoscopic features of synchronous multiple early gastric cancers: Findings from a nationwide cohort.

  Yoshito Hayashi, Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Yohei Yabuuchi, Shu Hoteya, Shigetsugu Tsuji, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Mitsushige Sugimoto, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribayashi, Shu Kiyotoki, Katsuhiro Mabe, Hiroyuki Kurakami, Mitsuhiro Fujishiro, Atsushi Masamune, Tetsuo Takehara

  INTRODUCTION: We investigated the factors associated with synchronous multiple early gastric cancers and determined their localization. METHODS: We analyzed 8191 patients who underwent endoscopic submucosal dissection for early gastric cancers at 33 hospitals in Japan from November 2013 to October 2016. Background factors were compared between single-lesion (n=7221) and synchronous multi-lesion cases (n=970) using univariate and multivariate analyses. We extracted cases with two synchronous lesions (n=832) and evaluated their localization. RESULTS: Significant independent risk factors for synchronous multiple early gastric cancer were older age (≥75 years old) (OR=1.257), male sex (OR=1.385), severe mucosal atrophy (OR=1.400), tumor localization in the middle (OR=1.362) or lower region (OR=1.404), and submucosal invasion (OR=1.528 (SM1), 1.488 (SM2)). Depressed macroscopic type (OR=0.679) and pure undifferentiated histology OR=0.334) were more common in single early gastric cancers. When one lesion was in the upper region, the other was more frequently located in the lesser curvature of the middle region. When one lesion was in the middle region, the other was more frequently located in the middle region or the lesser curvature of the lower region. When one lesion was in the lower region, the other was more frequently located in the lesser curvature of the middle region or the lower region. CONCLUSION: Factors associated with synchronous multiple early gastric cancer included older age, male sex, severe mucosal atrophy, tumor localization in the middle or lower region, and tumor submucosal invasion. Our findings provide useful information regarding specific areas that should be examined carefully when one lesion is detected.

  May 2024, Digestion, English, International magazine

  Scientific journal


• Randomised controlled, patient-blinded, multicentre, superiority trial to evaluate the efficacy of the line-attached sheath-type traction device for endoscopic submucosal dissection in patients with superficial gastric neoplasms

  Hirofumi Abe, Tomoya Sako, Yoshinobu Yamamoto, Atsushi Ikeda, Fumiaki Kawara, Takayuki Ose, Toshitatsu Takao, Yasuaki Kitamura, Ryusuke Ariyoshi, Yoshinori Morita, Tsukasa Ishida, Takuya Ikegawa, Ryosuke Ishida, Tetsuya Yoshizaki, Hiroya Sakaguchi, Takashi Toyonaga, Yuzo Kodama

  Apr. 2024, BMJ Open

  [Refereed]

  Scientific journal


• 多発胃癌の局在に関する検討

  林 義人, 八田 和久, 辻 陽介, 由雄 敏之, 籔内 洋平, 布袋屋 修, 辻 重継, 永見 康明, 引地 拓人, 小林 雅邦, 森田 圭紀, 住吉 徹哉, 井口 幹崇, 富田 英臣, 井上 拓也, 三上 達也, 波佐谷 兼慶, 藤城 光弘, 正宗 淳, 竹原 徹郎

  (一社)日本消化器内視鏡学会, Apr. 2024, Gastroenterological Endoscopy, 66(Suppl.1) (Suppl.1), 1038 - 1038, Japanese


• Outcomes of endoscopic submucosal dissection for esophageal cancer with segmental absence of intestinal musculature.

  Tetsuya Yoshizaki, Yoshinobu Yamamoto, Tomoya Sako, Yasuaki Kitamura, Takayuki Ose, Tsukasa Ishida, Atsushi Ikeda, Ryusuke Ariyoshi, Mineo Iwatate, Fumiaki Kawara, Shinwa Tanaka, Toshitatsu Takao, Yoshinori Morita, Takashi Toyonaga, Yuzo Kodama

  BACKGROUND AND AIMS: Perforation during esophageal endoscopic submucosal dissection (ESD) typically results from electrical damage. However, there are cases in which perforation occurs due to segmental absence of intestinal musculature (SAIM) without iatrogenic muscular injury. We investigated the occurrence rate and clinical course of SAIM during esophageal ESD. METHODS: We conducted a retrospective review of esophageal ESDs performed between 2013 and 2019 in 10 centers in Japan. RESULTS: Five of 1708 patients (0.29%) received ESD for esophageal cancer and had SAIM. The median muscular defect size was 20 mm. All lesions were resected without discontinuation. After resection, three patients were closed with Endoloop. Four patients had mediastinal emphysema. All patients were managed conservatively. CONCLUSIONS: SAIM is a very rare condition, which is usually only diagnosed during ESD. Physicians performing esophageal ESD should be aware about SAIM. When SAIM is detected, the ESD technique should be modified to prevent full-thickness perforation.

  Nov. 2023, Gastrointestinal endoscopy, English, International magazine

  Scientific journal


• Endoscopic full-thickness resection for gastric submucosal tumors: Japanese multicenter prospective study.

  Satoki Shichijo, Noriya Uedo, Atsushi Sawada, Kingo Hirasawa, Hirohisa Takeuchi, Nobutsugu Abe, Masaki Miyaoka, Kenshi Yao, Akira Dobashi, Kazuki Sumiyama, Tsukasa Ishida, Yoshinori Morita, Hiroyuki Ono

  OBJECTIVES: Early gastric cancer endoscopic resection (ER) is prominent in Japan. However, evidence regarding ER of gastric submucosal tumors (SMT) is limited. This prospective multicenter phase II study investigated the efficacy and safety of endoscopic full-thickness resection (EFTR) for gastric SMT. METHODS: Endoscopic full-thickness resection indication for gastric SMT was 11-30 mm, histologically proven or clinically suspicious (irregular margin, increasing size, or internal heterogeneity) gastrointestinal stromal tumors (GIST), with no ulceration and intraluminal growth type. The primary end-point was the complete ER (ER0) rate, with a sample size of 42. RESULTS: We enrolled 46 patients with 46 lesions between September 2020 and May 2023 at seven Japanese institutions. The mean ± SD (range) endoscopic tumor size was 18.8 ± 4.5 (11-28) mm. The tumor resection and defect closure times were 54 ± 26 (22-125) min and 33 ± 28 (12-186) min, respectively. A 100% ER0 was achieved in all 46 patients. The EFTR procedure was accomplished in all patients without surgical intervention. One patient had delayed perforation and was managed endoscopically. GIST accounted for 76% (n = 35) of the cases. R0, R1, and RX rates were 33 (77%), 3 (6.5%), and 7 (15%), respectively. CONCLUSION: Endoscopic full-thickness resection for gastric SMT of 11-30 mm is efficacious. It warrants further validation in a large-scale cohort study to determine the long-term outcome of this treatment for patients with gastric GIST.

  Nov. 2023, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, English, International magazine

  Scientific journal


• An Analysis of Delayed Bleeding in Cases of Colorectal Endoscopic Submucosal Dissection Due to Types of Direct Oral Anticoagulants in Japan.

  Naohisa Yoshida, Yoshikazu Hayashi, Daichi Togo, Shiro Oka, Kazunori Takada, Shusei Fukunaga, Yoshinori Morita, Takemasa Hayashi, Kazuhiro Kozuka, Yosuke Tsuji, Takashi Murakami, Takeshi Yamamura, Yoriaki Komeda, Yoji Takeuchi, Kensuke Shinmura, Hiroko Fukuda, Shinji Yoshii, Shoko Ono, Shinichi Katsuki, Kazumasa Kawashima, Daiki Nemoto, Hiroyuki Yamamoto, Yutaka Saito, Naoto Tamai, Aya Iwao, Yuki Itoi, Shigetsugu Tsuji, Yoshikazu Inagaki, Yutaka Inada, Koichi Soga, Daisuke Hasegawa, Takaaki Murakami, Hiroyuki Yoriki, Kohei Fukumoto, Takayuki Motoyoshi, Yasuki Nakatani, Yasushi Sano, Mikitaka Iguchi, Shigehiko Fujii, Hiromitsu Ban, Keita Harada, Koichi Okamoto, Hitoshi Nishiyama, Fumisato Sasaki, Kazujhiro Mizukami, Takashi Shono, Ryo Shimoda, Tadashi Miike, Naoyuki Yamaguchi

  BACKGROUND & AIMS: Reported rates of delayed bleeding (DB) after endoscopic resection using direct oral anticoagulants (DOACs) are high and heterogeneous. This large-scale multicenter study analyzed cases of DB after colorectal endoscopic submucosal dissection related to various types of DOACs in Japan (the ABCD-J study) with those associated with warfarin. METHODS: We retrospectively reviewed 1019 lesions in patients treated with DOACs and 459 lesions in patients treated with warfarin among 34,455 endoscopic submucosal dissection cases from 47 Japanese institutions between 2012 and 2021. The DB rate (DBR) with each DOAC was compared with that with warfarin. Risk factors for DB in patients treated with DOACs or warfarin were also investigated. RESULTS: The mean tumor sizes in the DOAC and warfarin groups were 29.6 ± 14.0 and 30.3 ± 16.4 mm, respectively. In the DOAC group, the DBR with dabigatran (18.26%) was significantly higher than that with apixaban (10.08%, P = .029), edoxaban (7.73%, P = .001), and rivaroxaban (7.21%, P < .001). Only rivaroxaban showed a significantly lower DBR than warfarin (11.76%, P = .033). In the multivariate analysis, heparin bridging therapy (odds ratio [OR], 2.18; 95% confidence interval [CI], 1.27-3.73, P = .005), rectal location (2.01, 1.28-3.16, P = .002), and procedure time ≥55 minutes (2.43, 1.49-3.95, P < .001) were significant risk factors for DB in the DOAC group. The DB risk in the DOAC group (OR, (95% CI)) was 2.13 (1.30-3.50) and 4.53 (2.52-8.15) for 1 and 2 significant risk factors, respectively. CONCLUSIONS: Dabigatran was associated with a higher DBR than other DOACs, and only rivaroxaban was associated with a significantly lower DBR than warfarin.

  Sep. 2023, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, English, International magazine

  Scientific journal


• Management of esophageal neoplasms by endoscopic submucosal dissection: experience over 100 consecutive procedures.

  Josué Aliaga Ramos, Yoshinori Morita, Takashi Toyonaga, Danilo Carvalho, Moises Salgado Pedrosa, Vitor N Arantes

  BACKGROUND/AIMS: Endoscopic submucosal dissection (ESD) is currently considered the first-line treatment for the eradication of superficial neoplasms of the esophagus in Eastern countries. However, in the West, particularly in Latin America, the experience with esophageal ESD is still limited because of the high technical complexity required for its execution. This study aimed to present the results of the clinical application of ESD to manage superficial esophageal neoplasms in a Latin American center in over 100 consecutive cases. METHODS: This retrospective study included consecutive patients who underwent endoscopic ESD for superficial esophageal neoplasms between 2009 and 2022. The following clinical outcomes were assessed: en bloc, complete, and curative resection rates, local recurrence, adverse events, and procedure-related mortality. RESULTS: Esophageal ESD was performed mainly for squamous cell carcinoma (66.6%), high-grade intraepithelial neoplasia (17.1%), and adenocarcinoma (11.4%). En bloc and complete resection rates were 96.2% and 81.0%, respectively. The curative resection rate was 64.8%. Adverse events occurred in six cases (5.7%). Endoscopic follow-up was performed for an average period of 29.7 months. CONCLUSION: ESD performed by trained operators is feasible, safe, and clinically effective for managing superficial neoplastic lesions of the esophagus in Latin America.

  Sep. 2023, Clinical endoscopy, 56(5) (5), 613 - 622, English, International magazine

  Scientific journal


• Assessment of predictive factors associated with the technical difficulty of endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma: Japanese multicenter retrospective study.

  Yoshinobu Yamamoto, Tetsuya Yoshizaki, Saeko Kushida, Shinwa Tanaka, Takayuki Ose, Tsukasa Ishida, Yasuaki Kitamura, Tomoya Sako, Mineo Iwatate, Atsushi Ikeda, Ryusuke Ariyoshi, Fumiaki Kawara, Hirofumi Abe, Toshitatsu Takao, Yoshinori Morita, Yasushi Sano, Eiji Umegaki, Hogara Nishisaki, Takashi Toyonaga, Yuzo Kodama

  OBJECTIVES: Endoscopic submucosal dissection (ESD) for superficial esophageal squamous cell carcinoma (ESCC) is performed for the treatment of lesions with varied backgrounds and factors. However, the predictive factors associated with the technical difficulty of ESD remain unknown in patients with varied lesions. Therefore, this study aimed to identify the predictive factors associated with the technical difficulty of ESD for ESCC using a retrospective cohort. METHODS: This multicenter, retrospective study was conducted in 10 hospitals in Japan. Consecutive patients who underwent esophageal ESD between January 2013 and December 2019 were enrolled. Lesions of subepithelial tumors, adenocarcinoma, and adenoma were excluded. Difficult lesions were defined as ESD requiring a long procedure time (≥120 min), perforation development, piecemeal resection, or discontinued ESD. In the present study, the clinical factors were assessed to identify the technical difficulty of ESD using univariate and multivariate analyses. RESULTS: Among 1708 lesions treated with esophageal ESD, eight subepithelial tumors, 44 adenocarcinomas, and two adenomas were excluded. Finally, 1505 patients with 1654 lesions were analyzed, and 217 patients with 217 lesions (13.1%) were classified as patients with difficult lesions. In multivariate analysis, the predictive factors associated with the technical difficulty of ESD were as follows: tumors with varices, tumors with diverticulum, antiplatelet use (discontinued), circumference of tumor (≥1/2), preoperative tumor size ≥30 mm, trainee, and nonhigh-volume center. CONCLUSION: This multicenter retrospective study identified the predictive factors associated with the technical difficulty of ESD for ESCC with varied backgrounds and factors.

  Aug. 2023, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, English, International magazine

  Scientific journal


• Safety and efficacy of endoscopic submucosal dissection for superficial esophageal cancer with esophageal varices.

  Tatsuya Nakai, Tetsuya Yoshizaki, Shinwa Tanaka, Yoshinobu Yamamoto, Tomoya Sako, Yasuaki Kitamura, Takayuki Ose, Tsukasa Ishida, Atsushi Ikeda, Ryusuke Ariyoshi, Mineo Iwatate, Fumiaki Kawara, Toshitatsu Takao, Yoshinori Morita, Takashi Toyonaga, Yuzo Kodama

  BACKGROUND: Heavy drinking is associated with esophageal cancer and esophageal varices. However, there are limited reports of endoscopic resection for esophageal cancer with esophageal varices. In this multicenter study, we clarified the safety and efficacy of endoscopic submucosal dissection for superficial esophageal cancer with esophageal varices. METHODS: In this multicenter, retrospective, observational study, patients underwent esophageal endoscopic submucosal dissection at 10 referral centers in Japan from January 2013 to December 2019. We analyzed characteristics including backgrounds and varices, treatment outcomes, and adverse events in cases with esophageal varices. RESULTS: A total of 1708 patients were evaluated, 27 (1.6%) of whom had esophageal varices. In patients with esophageal varices, the en bloc resection rate and R0 resection rate were 100% and 77.8%, respectively. Patients with esophageal varices had longer procedure times than patients without esophageal varices (p = 0.015). There was no significant difference in adverse events. There was no significant difference in procedure time and number of adverse events between patients who underwent pretreatment and those who did not. There was no significant difference in these outcomes for patients with lesions on varices compared to those without. Child-Pugh classification and location of the lesions also did not affect these outcomes. CONCLUSIONS: Esophageal cancer with esophageal varices could be treated endoscopically safely and effectively.

  Jul. 2023, Esophagus : official journal of the Japan Esophageal Society, 20(3) (3), 515 - 523, English, Domestic magazine

  Scientific journal


• Long-Term Outcomes of Endoscopic Submucosal Dissection for Early Remnant Gastric Cancer: A Retrospective Multicenter Study.

  Kazunori Tsuda, Shinwa Tanaka, Tetsuya Yoshizaki, Yoshinobu Yamamoto, Takayuki Ose, Tsukasa Ishida, Yasuaki Kitamura, Daisuke Obata, Mineo Iwatate, Atsushi Ikeda, Ryusuke Ariyoshi, Fumiaki Kawara, Hiroshi Takihara, Hirofumi Abe, Toshitatsu Takao, Yoshinori Morita, Yasushi Sano, Eiji Umegaki, Hogara Nishisaki, Takashi Toyonaga, Yuzo Kodama

  INTRODUCTION: Favorable long-term outcomes of endoscopic submucosal dissection (ESD) for early remnant gastric cancer (ERGC) have been reported in single-center studies from advanced institutions. However, no studies have examined the long-term outcomes using a multicenter database. This study aimed to investigate the long-term outcomes of the aforementioned approach using a large multicenter database. METHODS: This retrospective multicenter cohort study included 242 cases with 256 lesions that underwent ESD for ERGC between April 2009 and March 2019 across 12 centers. We investigated the long-term outcomes of these patients with the Kaplan-Meier method, and the relationship between curability, additional treatment, or hospital category, and the survival time was evaluated using the log-rank test. RESULTS: During the median follow-up period of 48.4 months, the 5-year overall survival rate was 81.3%, and the 5-year gastric cancer-specific survival rate was 98.1%. The survival time of patients of endoscopic curability (eCura) C-2 without additional surgery was significantly shorter than the corresponding of patients of eCura A/B/C-1 and eCura C-2 with additional surgery. There was no significant difference in either overall survival or gastric cancer-specific survival rate between the high-volume and non-high-volume hospitals. CONCLUSION: The gastric cancer-specific survival of ESD for ERGC using a multicenter database was favorable. ESD for ERGC is widely applicable regardless of the hospital case volume. Management in accordance with the latest guidelines will lead to long-term survival.

  Jun. 2023, Digestion, 1 - 10, English, International magazine

  Scientific journal


• Anatomical Analysis of the Gonadal Veins and Spine in Lateral Lumbar Interbody Fusion.

  Yujiro Kagami, Hiroaki Nakashima, Kotaro Satake, Kenyu Ito, Mikito Tsushima, Naoki Segi, Hiroyuki Tomita, Jun Ouchida, Yoshinori Morita, Yukihito Ode, Shiro Imagama, Tokumi Kanemura

  BACKGROUND: The current study aimed to investigate the anatomical position of the gonadal veins (GVs) from the viewpoint of spine surgery and the risk factors associated with lateral lumbar interbody fusion (LLIF). METHODS: This retrospective study included 99 consecutive patients. The GV locations were divided into the ventral (V), dorsal medial (DM), and dorsal lateral (DL) sides based on lumbar disk levels on axial contrast-enhanced computed tomography images. The DM region surrounded by the vertebral body and psoas muscle had the highest risk of GV injury. The GV at each intervertebral disk level was examined in terms of laterality and sex. The patients were divided into group M (which included those with GV in the DM region at any vertebral level) and group O (which included those without GV in the DM region at any vertebral level). Then, the two groups were compared. RESULTS: In the case of lower lumbar levels and in women, the GVs were commonly observed in the DM region. Group M had a higher incidence of degenerative scoliosis than group O and a significantly larger Cobb angle. CONCLUSIONS: We should pay close attention to the GV location on the preoperative image when using LLIF, particularly in female patients with degenerative scoliosis.

  Apr. 2023, Journal of clinical medicine, 12(8) (8), English, International magazine

  Scientific journal


• Clinicopathological Features and the Prevalence of Oxyntic Gland Neoplasm: A Single-center Retrospective Study.

  Hikari Asahara, Toshitatsu Takao, Yumiko Asahara, Masakyo Asahara, Douglas Motomura, Hiroya Sakaguchi, Tetsuya Yoshizaki, Nobuaki Ikezawa, Madoka Takao, Yoshinori Morita, Takashi Toyonaga, Masato Komatsu, Ryoji Kushima, Yuzo Kodama

  Objective We explored the clinicopathological characteristics and disease frequency of oxyntic gland neoplasms (OGNs). Methods We retrospectively evaluated the data of patients pathologically diagnosed with OGN at an internal medicine clinic. Patients A total of 13,240 upper gastrointestinal endoscopies were performed on 7,488 patients between December 1, 2017, and March 31, 2021. Results We identified 27 patients with 30 histopathologically confirmed OGNs, yielding a disease frequency of 0.36% (27/7,488). Furthermore, multiple simultaneous lesions were found in 3 of 27 patients (11%). One (3.3%) of the 30 lesions was present in the antrum, whereas the remaining lesions occurred in the body of the stomach. Nine (33%) of the 27 patients had no history of Helicobacter pylori infection, whereas the remaining 18 (67%) were either currently or had been previously infected. Nevertheless, 27/30 lesions (90%) still occurred in non-atrophied regions. After endoscopic treatment, a histopathological examination of the resected specimens revealed submucosal infiltration in 8 (44%) of the 18 lesions; however, none of the lesions showed submucosal desmoplasia. For all patients with submucosal involvement, only observation was performed. There were no recurrent lesions found on follow-up. Conclusion The period prevalence of OGN was 0.36%, which is much higher than previously reported. The discovery of a small submucosal appearing lesion with a faded yellow or white color and dilated microvasculature, especially in a non-atrophic area of the stomach, should raise suspicion for an OGN, which can be endoscopically managed.

  Feb. 2023, Internal medicine (Tokyo, Japan), English, Domestic magazine

  Scientific journal


• Association between perioperative management of antiplatelet agents and risk of post-endoscopic submucosal dissection bleeding in early gastric cancer: an analysis of a nationwide multicenter study.

  Yuko Miura, Yosuke Tsuji, Toshiyuki Yoshio, Waku Hatta, Yohei Yabuuchi, Shu Hoteya, Daisuke Kikuchi, Shigetsugu Tsuji, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Mitsushige Sugimoto, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribayashi, Shu Kiyotoki, Katsuhiro Mabe, Atsushi Masamune, Mitsuhiro Fujishiro

  BACKGROUND AND AIMS: Data about the detail of post-endoscopic submucosal dissection (ESD) bleeding in patients with early gastric cancer (EGC) who take antiplatelet agents (APAs), particularly in those taking thienopyridine and cilostazol, are lacking. We aimed to clarify the association between the status of APA medication and post-ESD bleeding risk. METHODS: This study is a secondary analysis using data from a recently conducted nationwide multicenter study in Japan. We retrospectively reviewed patients treated with APAs or on no antithrombotic therapy recruited from 33 institutions who underwent ESD for EGC between November 2013 and October 2016. The primary outcome of this study was the relationship between the rate of post-ESD bleeding and the status of each APA medication. RESULTS: A total of 9736 patients were included in the analysis. Among aspirin users (n=665), the continuation group was significantly associated with post-ESD bleeding (odds ratio [OR], 2.79; 95% confidence interval (CI), 1.77-4.37). Among thienopyridine users (n=227), the aspirin or cilostazol replacement group was not significantly associated with post-ESD bleeding (OR, 1.85; 95% CI, 0.72-4.78). Among cilostazol users (n=158), there was no significant association with post-ESD bleeding, irrespective of medication status. The rate of post-ESD bleeding was approximately 10-20% irrespective of the status of APA administration among dual antiplatelet therapy users. No patients experienced thromboembolic events in this study. CONCLUSIONS: Replacement of thienopyridine with aspirin/cilostazol may be acceptable for minimizing both the risk of post-ESD bleeding and thromboembolism in patients with EGC. In patients on cilostazol monotherapy undergoing ESD, continuation of therapy may be acceptable.

  Jan. 2023, Gastrointestinal endoscopy, 97(5) (5), 889 - 897, English, International magazine

  Scientific journal


• Characteristics of Gastric Stasis due to Deformation after Endoscopic Submucosal Dissection in the Lower Part of the Stomach.

  Hiroshi Takayama, Takashi Toyonaga, Tetsuya Yoshizaki, Hirofumi Abe, Tatsuya Nakai, Chise Ueda, Satoshi Urakami, Hidetoshi Kaku, Yusaku Shimamoto, Kei Matsumoto, Kazunori Tsuda, Hiroya Sakaguchi, Shinichi Baba, Hiroshi Takihara, Nobuaki Ikezawa, Shinwa Tanaka, Madoka Takao, Toshitatsu Takao, Yoshinori Morita, Yuzo Kodama

  INTRODUCTION: Gastric stasis due to deformation occurs after endoscopic submucosal dissection in the lower part of the stomach. Endoscopic balloon dilation can improve gastric stasis due to stenosis; however, endoscopic balloon dilation cannot improve gastric stasis due to deformation. Furthermore, the characteristics of gastric stasis due to deformation are unknown. This study aimed to evaluate the characteristics of gastric stasis due to deformation after endoscopic submucosal dissection in the lower part of the stomach, focusing on the differences between stenosis and deformation. METHODS: We retrospectively reviewed 41 patients with gastric stasis after endoscopic submucosal dissection in the lower part of the stomach. We evaluated the characteristics of cases with gastric stasis due to deformation, such as the risk factors of deformation and the rate of deformation in each group with risk factors. RESULTS: Deformation was observed in 12% (5/41) of the patients with gastric stasis. All cases of deformation had a circumferential extent of the mucosal defect greater than 3/4. The number of cases with pyloric dissection was significantly lower in the deformation group than in the non-deformation group (0% vs. 72%; p = 0.004). The deformation group also had a significantly higher number of cases with angular dissection than the non-deformation group (100% vs. 17%; p < 0.001). Moreover, the deformation cases had a significantly larger specimen diameter (p < 0.001). Deformation was observed only in cases with angular and non-pyloric dissections. Deformation was not observed in cases with angular and pyloric dissections. CONCLUSIONS: All cases of gastric stasis due to deformation had a circumferential extent of the mucosal defect greater than 3/4. Deformation was also likely to occur in cases with a larger dissection that exceeded the angular region without pyloric dissection.

  2023, Digestion, 104(4) (4), 320 - 327, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 手技の解説 表在性非乳頭部十二指腸腫瘍に対する腹腔鏡内視鏡合同手術

  森田 圭紀, 鷹尾 俊達, 金治 新悟

  (一社)日本消化器内視鏡学会, Dec. 2022, Gastroenterological Endoscopy, 64(12) (12), 2524 - 2532, Japanese


• 早期胃癌に対する内視鏡的粘膜下層剥離術後の再出血

  橋本 陽, 八田 和久, 辻 陽介, 由雄 敏之, 籔内 洋平, 布袋屋 修, 土山 寿志, 永見 康明, 引地 拓人, 小林 雅邦, 森田 圭紀, 住吉 徹哉, 井口 幹崇, 富田 英臣, 井上 拓也, 三上 達也, 波佐谷 兼慶, 西川 潤, 松村 倫明, 根引 浩子, 中松 大, 大仁田 賢, 鈴木 晴久, 上山 浩也, 林 義人, 杉本 光繁, 藤城 光弘, 正宗 淳, 大平 弘正

  (一社)日本消化器内視鏡学会, Nov. 2022, Gastroenterological Endoscopy, 64(11) (11), 2421,np1 - np3, Japanese


• Final analysis of diagnostic endoscopic resection followed by selective chemoradiotherapy for stage I esophageal cancer: JCOG0508.

  Keiji Nihei, Keiko Minashi, Tomonori Yano, Tadakazu Shimoda, Haruhiko Fukuda, Manabu Muto, Junki Mizuaswa, Kohei Takizawa, Ikuo Aoyama, Akiyoshi Ishiyama, Noboru Kawata, Daisuke Kikuchi, Noboru Hanaoka, Ichiro Oda, Yoshinori Morita, Masahiro Tajika, Junko Fujiwara, Yoshinobu Yamamoto, Chikatoshi Katada, Shinichiro Hori, Hisashi Doyama, Tsuneo Oyama, Hiroko Nebiki, Kenji Amagai, Yutaro Kubota, Yasuhiro Inokuchi, Nozomu Kobayashi, Takuto Suzuki, Kingo Hirasawa, Toshihisa Takeuchi, Tomohiro Kadota

  Oct. 2022, Gastroenterology, 164(2) (2), 296 - 299, English, International magazine

  Scientific journal


• Laparoscopic Endoscopic Cooperative Surgery Using Open-Window Suturing Technique for Treating Non-ampullary Superficial Duodenal Neoplasms Located on the Pancreatic Side.

  Shingo Kanaji, Yoshinori Morita, Takuya Kudo, Kouta Yamada, Takashi Kato, Arata Sakai, Toshitatsu Takao, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Takashi Toyonaga, Yuzo Kodama, Yoshihiro Kakeji

  PURPOSE: No study has focused on the safety and feasibility of our previously developed open-window suturing technique to close mucosal defects on the pancreatic side after endoscopic submucosal dissection from the opened duodenal wall. This study aimed to evaluate the safety and usefulness of laparoscopic endoscopic cooperative surgery for duodenal tumors for treating superficial non-ampullary duodenal epithelial tumors on the pancreatic side of the duodenum. METHODS: This retrospective study included 61 consecutive patients who underwent surgery during August 2014-November 2021. After dissection when the tumor was on the pancreatic side, we sutured the mucosal defect from the opened duodenal wall. A preoperative endoscopic pancreatic stent was placed for tumors within 1 cm of the ampulla of Vater. The surgical outcomes were compared between tumors on the pancreatic and non-pancreatic sides. RESULTS: There were 27 and 34 patients with tumors on the pancreatic and non-pancreatic sides, respectively. The patient characteristics were similar. Preoperative pancreatic stents were placed in four patients in the pancreatic side group. The median operative time was significantly longer on the pancreatic side than in the non-pancreatic side group (241 vs. 209 min, P = 0.02). In one patient in the pancreatic side group, an intraoperative injury of the ampulla of Vater was successfully treated with intraoperative management. There were no significant differences in the incidence of postoperative grade II or higher complications between the groups. CONCLUSIONS: Laparoscopic endoscopic cooperative surgery for duodenal tumors for treating superficial non-ampullary duodenal epithelial tumors on the pancreatic side is safe and feasible.

  Jul. 2022, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 26(11) (11), 2266 - 2273, English, International magazine

  Scientific journal


• Efficacy of polyglycolic acid sheeting with fibrin glue for perforations related to gastrointestinal endoscopic procedures: a multicenter retrospective cohort study.

  Kengo Takimoto, Noriko Matsuura, Yoshiko Nakano, Yosuke Tsuji, Kohei Takizawa, Yoshinori Morita, Yasuaki Nagami, Kingo Hirasawa, Hiroshi Araki, Naoyuki Yamaguchi, Hiroyuki Aoyagi, Tamotsu Matsuhashi, Toshiro Iizuka, Hisanobu Saegusa, Kenji Yamazaki, Shinichiro Hori, Tomohiko Mannami, Noboru Hanaoka, Hirohito Mori, Hideki Kobara, Yoji Takeuchi, Hiroyuki Ono

  OBJECTIVES: Gastrointestinal (GI) perforations are one of the major adverse events of endoscopic procedures. Polyglycolic acid (PGA) sheets with fibrin glue have been reported to close GI perforations. However, its clinical outcome has not yet been fully investigated; thus, we conducted a multicenter retrospective observational study to assess the efficacy of PGA sheeting for GI perforation. METHODS: The medical records of patients who underwent PGA sheeting for endoscopic GI perforations between April 2013 and March 2018 in 18 Japanese institutions were retrospectively analyzed. PGA sheeting was applied when the clip closure was challenging or failed to use. Perforations were filled with one or several pieces of PGA sheets followed by fibrin glue application through an endoscopic catheter. Nasal or percutaneous drainage and endoscopic clipping were applied as appropriate. Clinical outcomes after PGA sheeting for intraoperative or delayed perforations were separately evaluated. RESULTS: There were 66 intraoperative and 24 delayed perforation cases. In intraoperative cases, successful closure was attained in 60 cases (91%). The median period from the first sheeting to diet resumption was 6 days (interquartile range [IQR], 4-8.8 days). Large perforation size (≥ 10 mm) and duodenal location showed marginal significant relationship to higher closure failure of intraoperative perforations. In delayed perforation cases, all cases had successful closure. The median period from the first sheeting to diet resumption was 10 days (IQR, 6-37.8 days). No adverse events related to PGA sheeting occurred. CONCLUSION: Endoscopic PGA sheeting could be a therapeutic option for GI perforations related to GI endoscopic procedures.

  Jul. 2022, Surgical endoscopy, 36(7) (7), 5084 - 5093, English, International magazine

  Scientific journal


• Speech Recognition System Generates Highly Accurate Endoscopic Reports in Clinical Practice.

  Hiroshi Takayama, Toshitatsu Takao, Ryo Masumura, Yoshikazu Yamaguchi, Ryo Yonezawa, Hiroya Sakaguchi, Yoshinori Morita, Takashi Toyonaga, Kazutaka Izumiyama, Yuzo Kodama

  Objective Endoscopic reports are conventionally written at the end of each procedure, and the endoscopist must complete the report from memory. To make endoscopic reporting more efficient, we developed a new speech recognition (SR) system that generates highly accurate endoscopic reports based on structured data entry. We conducted a pilot study to examine the performance of this SR system in an actual endoscopy setting with various types of background noise. Methods In this prospective observational pilot study, participants who underwent upper endoscopy with our SR system were included. The primary outcome was the correct recognition rate of the system. We compared the findings generated by the SR system with the findings in the handwritten report prepared by the endoscopist. The initial correct recognition rate, number of revisions, finding registration time, and endoscopy time were also analyzed. Results Upper endoscopy was performed in 34 patients, generating 128 findings of 22 disease names. The correct recognition rate was 100%, and the median number of revisions was 0. The median finding registration time was 2.57 (interquartile range [IQR], 2.33-2.92) seconds, and the median endoscopy time was 234 (IQR, 194-227) seconds. Conclusion The SR system demonstrated high recognition accuracy in the clinical setting. The finding registration time was extremely short.

  Jun. 2022, Internal medicine (Tokyo, Japan), English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Feasibility and safety of endoscopic submucosal dissection for lesions in proximity to a colonic diverticulum.

  Nobuaki Ikezawa, Takashi Toyonaga, Shinwa Tanaka, Tetsuya Yoshizaki, Toshitatsu Takao, Hirofumi Abe, Hiroya Sakaguchi, Kazunori Tsuda, Satoshi Urakami, Tatsuya Nakai, Taku Harada, Kou Miura, Takahisa Yamasaki, Stuart Kostalas, Yoshinori Morita, Yuzo Kodama

  BACKGROUND/AIMS: Endoscopic submucosal dissection (ESD) for diverticulum-associated colorectal lesions is generally contraindicated because of the high risk of perforation. Several studies on patients with such lesions treated with ESD have been reported recently. However, the feasibility and safety of ESD for lesions in proximity to a colonic diverticulum (D-ESD) have not been fully clarified. The aim of this study was to evaluate the feasibility and safety of D-ESD. METHODS: D-ESD was defined as ESD for lesions within approximately 3 mm of a diverticulum. Twenty-six consecutive patients who underwent D-ESD were included. Two strategic approaches were used depending on whether submucosal dissection of the diverticulum-related part was required (strategy B) or not (strategy A). Treatment outcomes and adverse events associated with each strategy were analyzed. RESULTS: The en bloc resection rate was 96.2%. The rates of R0 and curative resection in strategies A and B were 80.8%, 73.1%, 84.6%, and 70.6%, respectively. Two cases of intraoperative perforation and one case of delayed perforation occurred. The delayed perforation case required emergency surgery, but the other cases were managed conservatively. CONCLUSION: D-ESD may be a feasible treatment option. However, it should be performed in a high-volume center by expert hands because it requires highly skilled endoscopic techniques.

  May 2022, Clinical endoscopy, 55(3) (3), 417 - 425, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The degree of mucosal atrophy is associated with post-endoscopic submucosal dissection bleeding in early gastric cancer.

  Yoshito Hayashi, Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Yohei Yabuuchi, Shu Hoteya, Shigetsugu Tsuji, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Mitsushige Sugimoto, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribayashi, Shu Kiyotoki, Katsuhiro Mabe, Akimitsu Miyake, Mitsuhiro Fujishiro, Atsushi Masamune, Tetsuo Takehara

  BACKGROUND AND AIM: Despite the widespread use of endoscopic submucosal dissection (ESD) for early gastric cancer, post-ESD bleeding remains a significant problem. Intragastric pH plays an important role in intragastric bleeding. Because gastric acid secretion contributes to intragastric pH, both the presence or absence of Helicobacter pylori infection and the degree of gastric mucosal atrophy may affect bleeding. The present study aimed to clarify the relationship between post-ESD bleeding and the degree of gastric mucosal atrophy based on H. pylori infection status. METHODS: We included 8170 patients who underwent ESD for early gastric cancer at 33 hospitals in Japan from November 2013 to October 2016. We analyzed the risk factors contributing to post-ESD bleeding. RESULTS: There were 3935 H. pylori-positive patients and 4235 H. pylori-negative patients. A nonsevere degree of gastric mucosal atrophy was an independent risk factor for post-ESD bleeding in H. pylori-negative patients (odds ratio: 1.51, P = 0.007), but not in H. pylori-positive patients (odds ratio: 0.91, P = 0.600). Further, in H. pylori-negative, but not H. pylori-positive, patients, the rate of post-ESD bleeding increased in a stepwise manner for patients continuing antithrombotic drug use, patients who withdrew antithrombotic drug use, and antithrombotic drug nonusers. CONCLUSIONS: Nonsevere gastric mucosal atrophy was a risk factor for post-ESD bleeding in early gastric cancer in H. pylori-negative patients but not in H. pylori-positive patients.

  May 2022, Journal of gastroenterology and hepatology, 37(5) (5), 870 - 877, English, International magazine

  Scientific journal


• The importance of pH adjustment for preventing fibrin glue dissolution in the stomach: an in vitro study.

  Yoshitaka Takegawa, Toshitatsu Takao, Hiroya Sakaguchi, Tatsuya Nakai, Kazuhiro Takeo, Yoshinori Morita, Takashi Toyonaga, Yuzo Kodama

  Combined use of fibrin glue and polyglycolic acid (PGA) sheets has attracted attention as a preventive measure for complications associated with endoscopic submucosal dissection. However, fibrin glue is a protein that may be dissolved by gastric acid. We evaluated the effect of artificial gastric acid on fibrin clot. The dissolution time of three layers of fibrin glue with PGA sheets was measured in five groups (pH 1.2, 2.0, 4.0, 5.5, and 6.0 with pepsin). Measurements of three samples per group were made. The mean number of the remaining layers at each measurement point was observed for 168 h. The time to complete dissolution of the three layers of fibrin gel in the three samples was 2.5 h at pH 1.2, 5 h at pH 2.0, 24 h at pH 4.0, and 48 h and 6 h at pH 5.5. In order to maintain fibrin glue in the stomach for a long period, there was a need to avoid pepsin activation secondary to acidification of gastric juice. The use of strong antacids is recommended.

  Apr. 2022, Scientific reports, 12(1) (1), 6986 - 6986, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Second gastric cancer after curative endoscopic resection of differentiated-type early gastric cancer: post-hoc analysis of a single-arm confirmatory trial.

  Masao Yoshida, Kohei Takizawa, Noriaki Hasuike, Hiroyuki Ono, Narikazu Boku, Tomohiro Kadota, Junki Mizusawa, Ichiro Oda, Naohiro Yoshida, Yusuke Horiuchi, Kingo Hirasawa, Yoshinori Morita, Yoshinobu Yamamoto, Manabu Muto

  BACKGROUND AND AIMS: Endoscopic resection (ER) for early gastric cancer (EGC) can preserve the stomach; however, the remaining stomach can develop second gastric cancer. Few reports have prospectively investigated the incidence and treatment outcomes of second gastric cancer. METHODS: This post-hoc analysis used the dataset of the single-arm confirmatory trial, JCOG0607. The key inclusion criteria for JCOG0607 were solitary differentiated-type EGC and no previous gastrectomy or endoscopic treatment for EGC. Three hundred seventeen patients who underwent curative ER were included in this study. Surveillance endoscopy was performed 1 to 3 months after the initial ER and subsequently annually for at least 5 years. A lesion detected ≤1 year and >1 year after the initial ER was defined as overlooked gastric cancer (OGC) and metachronous gastric cancer (MGC), respectively. RESULTS: During a median follow-up period of 6.0 years (interquartile range, 5.1-7.0), 30 OGCs and 61 MGCs were detected in 24 and 48 patients, respectively. The cumulative incidence of OGC at 1 year and MGC at 5 years was 7.6% and 12.7%, respectively. ER and gastrectomy were performed in 85 lesions and 6 lesions, respectively. Pathologic evaluation showed 78 mucosal cancers, 12 submucosal cancers, and 1 advanced cancer. Eventually, 28 OGCs and 52 MGCs fulfilled the pathologic criteria for curative ER. CONCLUSIONS: Our study was the first to reveal the actual incidence of second gastric cancer after curative ER for differentiated-type gastric cancer. Most lesions could be treated with ER. Continuous endoscopic surveillance after curative ER is important to detect second gastric cancer.

  Apr. 2022, Gastrointestinal endoscopy, 95(4) (4), 650 - 659, English, International magazine

  Scientific journal


• Effect of chemoradiation on the development of second primary cancers after endoscopic resection of T1 esophageal squamous cell carcinoma

  Toshiyuki Yoshio, Keiko Minashi, Junki Mizusawa, Yoshinori Morita, Masahiro Tajika, Junko Fujiwara, Yoshinobu Yamamoto, Chikatoshi Katada, Shinichiro Hori, Tomonori Yano, Kohei Takizawa, Haruhiko Fukuda, Manabu Muto

  Springer Science and Business Media LLC, Mar. 2022, Esophagus

  Scientific journal


• 貧血症状を契機に発見されESDにて切除し得た巨大十二指腸Brunner腺過形成の一例

  賀来 英俊, 吉崎 哲也, 中井 達也, 高山 弘志, 津田 一範, 松本 慶, 池澤 伸明, 阪口 博哉, 阿部 洋文, 鷹尾 まど佳, 鷹尾 俊達, 森田 圭紀, 豊永 高史, 児玉 貴之, 横崎 宏, 伊藤 智雄, 児玉 裕三

  日本消化器病学会-近畿支部, Feb. 2022, 日本消化器病学会近畿支部例会プログラム・抄録集, 116回, 124 - 124, Japanese


• Bleeding following Endoscopic Submucosal Dissection for Early Gastric Cancer in Surgically Altered Stomach.

  Hiroyuki Odagiri, Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Yohei Yabuuchi, Daisuke Kikuchi, Shigetsugu Tsuji, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Mitsushige Sugimoto, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribayashi, Shu Kiyotoki, Katsuhiro Mabe, Mitsuhiro Fujishiro, Atsushi Masamune, Shu Hoteya

  INTRODUCTION: Few studies have focused on bleeding following endoscopic submucosal dissection (ESD) in surgically altered stomach. We aimed to reveal the bleeding risk in surgically altered stomach following ESD for early gastric cancer (EGC). METHODS: We enrolled patients with ESD for EGC at 33 institutions between 2013 and 2016. In study 1, we evaluated bleeding risk following ESD in surgically altered stomach, compared with whole stomach. In study 2, we evaluated factors associated with bleeding following ESD in patients with surgically altered stomach. RESULTS: Of 11,452 patients, 445 patients had surgically altered stomach with the bleeding rate following ESD of 4.9%. In study 1, the bleeding risk in surgically altered stomach was not significant (odds ratio [OR], 1.37; 95% confidence interval [CI], 0.87-2.17) in the multivariate logistic regression analysis. No significant results were obtained when the surgically altered stomach was subdivided into various types. In study 2, the multivariate logistic regression analysis revealed that independent risk factors for bleeding following ESD were ischemic heart disease (OR, 7.52; 95% CI, 2.00-28.25) and P2Y12 receptor antagonist (OR, 4.81; 95% CI, 1.21-19.14). DISCUSSION/CONCLUSION: In this nationwide study, we found that the bleeding risk of surgically altered stomach following ESD for EGC did not significantly differ from that of whole stomach. The risk factors for ESD in patients with surgically altered stomach were ischemic heart disease and P2Y12 receptor antagonist.

  2022, Digestion, 103(6) (6), 428 - 437, English, International magazine

  Scientific journal


• 【腹腔鏡・内視鏡合同手術(LECS)の現状と展望】高難度LECS 非乳頭部十二指腸腫瘍に対するLECS

  金治 新悟, 裏川 直樹, 鷹尾 俊達, 森田 圭紀, 豊永 高史, 掛地 吉弘

  金原出版(株), Oct. 2021, 手術, 75(11) (11), 1673 - 1677, Japanese


• Timing of bleeding and thromboembolism associated with endoscopic submucosal dissection for gastric cancer in Japan.

  Sho Shiroma, Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Yohei Yabuuchi, Shu Hoteya, Shigetsugu Tsuji, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Mitsushige Sugimoto, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribayashi, Shu Kiyotoki, Katsuhiro Mabe, Mitsuhiro Fujishiro, Atsushi Masamune, Junko Fujisaki

  BACKGROUND AND AIM: This study aimed to reveal the timing of bleeding and thromboembolism associated with endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). METHODS: We retrospectively reviewed  10,320 patients who underwent ESD for EGC during November 2013-October 2016. We evaluated overall bleeding rates and their inter-group differences. Factors associated with early/late (cut-off 5 days) bleeding and thromboembolism frequency and its association with the intake of antithrombotic agents were investigated. RESULTS: Overall, the post-ESD bleeding rate was 4.7% (489/10 320); the median time to post-ESD bleeding was 4 days. The post-ESD bleeding rates were 3.2%, 8.7%, 15.5%, and 29.9% in those not taking antithrombotic agents, those taking antiplatelet agents, those taking anticoagulants (ACs), and those taking antiplatelet agents and ACs. Warfarin (odds ratio [OR], 9.16), direct oral ACs (OR, 4.16), chronic kidney disease with hemodialysis (OR, 2.93), thienopyridine (OR, 2.25), aspirin (OR, 1.66), tumor size >30 mm (OR, 1.86), multiple tumors' resection (OR, 1.54), and tumor in the lower third of the stomach (OR, 1.40) were independent risk factors for early bleeding. The independent risk factors for late bleeding were direct oral ACs (OR, 7.42), chronic kidney disease with hemodialysis (OR, 4.99), warfarin (OR, 3.90), thienopyridine (OR, 3.09), liver cirrhosis (OR, 2.43), cilostazol (OR, 1.93), aspirin (OR, 1.92), ischemic heart disease (OR, 1.77), and male sex (OR, 1.65). There were three (0.03%) thromboembolic events (cerebral infarction = 2, transient ischemic attack = 1). CONCLUSION: We revealed the timing of bleeding and risk factors for early/late bleeding and showed the thromboembolism frequency associated with ESD for EGC.

  Oct. 2021, Journal of gastroenterology and hepatology, 36(10) (10), 2769 - 2777, English, International magazine

  Scientific journal


• Antithrombotics increase bleeding after endoscopic submucosal dissection for gastric cancer: Nationwide propensity score analysis.

  Yasuaki Nagami, Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Naomi Kakushima, Shu Hoteya, Shigetsugu Tsuji, Shusei Fukunaga, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Hisako Yoshida, Mitsuhiro Fujishiro, Atsushi Masamune, Yasuhiro Fujiwara

  OBJECTIVES: Post-operative bleeding is the most common adverse event in endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). Patients taking antithrombotic agents has increased. We evaluated the influence of antithrombotic agents on delayed bleeding in ESD for EGC. METHODS: This was a post hoc analysis of nationwide, multicenter, retrospective cohort study in Japan. Altogether, 11,452 patients who underwent ESD for EGC in 33 institutions between November 2013 and October 2016 were enrolled. The primary outcome was the incidence of delayed bleeding in patients with or without antithrombotic agents. The secondary outcome was the incidence of delayed bleeding in those who took each antithrombotic agent and the cessation status of its use compared with each matched pair of patients. We used propensity matching and inverse probability of treatment weighting (IPTW) analyses. RESULTS: There were 1353 matched pairs of patients. The incidence of delayed bleeding was 2.8% and 10.7% in those without and with antithrombotic agents, respectively (odds ratio [OR] 4.15, 95% confidence interval [CI] 2.88-5.99; P < 0.001). The IPTW analysis showed similar results (OR 4.21, 95% CI 3.48-5.08; P < 0.001). Antiplatelets, anticoagulants, and their combination increased such incidence. Heparin bridging therapy had high OR (8.80), and the continuation (OR 3.46) and cessation (OR 2.95) of antithrombotic agent use had similar risk. CONCLUSIONS: Antithrombotic agents increased the incidence of delayed bleeding in patients who underwent ESD for EGC. Continuing antithrombotics may be more appropriate than heparin bridging therapy.

  Sep. 2021, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 34(5) (5), 974 - 983, English, International magazine

  Scientific journal


• Risk Factors for Bleeding After Endoscopic Submucosal Dissection for Gastric Cancer in Elderly Patients Older Than 80 Years in Japan.

  Mitsushige Sugimoto, Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Yohei Yabuuchi, Shu Hoteya, Hisashi Doyama, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Masaki Murata, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribayashi, Shu Kiyotoki, Katsuhiro Mabe, Mitsuhiro Fujishiro, Atsushi Masamune, Takashi Kawai

  INTRODUCTION: As the aging of people in a society advances, the number of elderly patients older than 80 years in Japan with gastric cancer continues to increase. Although delayed ulcer bleeding is a major adverse event after endoscopic submucosal dissection (ESD), little is known about characteristic risk factors for bleeding in elderly patients undergoing ESD. This study aimed to evaluate risk factors for delayed bleeding after ESD for gastric cancer in elderly patients older than 80 years. METHODS: We retrospectively evaluated the incidence of delayed bleeding after ESD in 10,320 patients with early-stage gastric cancer resected by ESD between November 2013 and January 2016 at 33 Japanese institutions and investigated risk factors for delayed bleeding in elderly patients older than 80 years. RESULTS: The incidence of delayed bleeding in elderly patients older than 80 years was 5.7% (95% confidence interval [CI]: 4.6%-6.9%, 95/1,675), which was significantly higher than that in nonelderly (older than 20 years and younger than 80 years) patients (4.5%, 4.1%-5.0%, 393/8,645). Predictive factors for ESD-associated bleeding differed between nonelderly and elderly patients. On multivariate analysis of predictive factors at the time of treatment, risk factors in elderly patients were hemodialysis (odds ratio: 4.591, 95% CI: 2.056-10.248, P < 0.001) and warfarin use (odds ratio: 4.783, 95% CI: 1.689-13.540, P = 0.003). DISCUSSION: This multicenter study found that the incidence of delayed bleeding after ESD in Japanese patients older than 80 years was high, especially in patients receiving hemodialysis and taking warfarin. Management of ESD to prevent delayed bleeding requires particular care in patients older than 80 years.

  Sep. 2021, Clinical and translational gastroenterology, 12(9) (9), e00404, English, International magazine

  Scientific journal


• Influence of hospital volume on bleeding after endoscopic submucosal dissection for early gastric cancer in Japan: a multicenter propensity score-matched analysis.

  Yohei Yabuuchi, Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Naomi Kakushima, Shu Hoteya, Hisashi Doyama, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Mitsushige Sugimoto, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribayashi, Shu Kiyotoki, Katsuhiro Mabe, Mitsuhiro Fujishiro, Atsushi Masamune, Hiroyuki Ono

  BACKGROUND: Information on whether there is a relationship between hospital volume and bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is limited. This study aimed to compare the bleeding rates after ESD for EGC according to the hospital volume. METHODS: Patients who underwent ESD for EGC at 33 institutions in Japan between November 2013 and October 2016 were included in this multicenter retrospective study. Hospital volume was categorized into three groups, based on the average annual number of ESD procedures: low- and medium-volume group (LMVG), high-volume group (HVG), and very high-volume group (VHVG). The bleeding rate after ESD for EGC was compared between the three hospital volume groups after propensity score matching. RESULTS: A total of 10,320 patients, including 2797 patients in the LMVG, 4646 patients in the HVG, and 2877 patients in the VHVG, were identified. Propensity score matching yielded 2002 patients in each hospital volume group, with an improved balance of confounding variables between the three groups. The bleeding rates in the LMVG, HVG, and VHVG were 4.3%, 3.7%, and 4.9%, respectively, and no significant difference was noted between the three groups. CONCLUSIONS: The bleeding rate after ESD for EGC did not differ between hospitals in Japan. The finding indicated that ESD for EGC is equally feasible across Japanese hospitals of different volumes regarding bleeding after ESD.

  Sep. 2021, Surgical endoscopy, 36(6) (6), 4004 - 4013, English, International magazine

  Scientific journal


• Clinical Impact of Different Reconstruction Methods on Remnant Gastric Cancer at the Anastomotic Site after Distal Gastrectomy

  Kei Matsumoto, Shinwa Tanaka, Takashi Toyonaga, Nobuaki Ikezawa, Mari Nishio, Masanao Uraoka, Tomoatsu Yoshihara, Hiroya Sakaguchi, Hirofumi Abe, Tetsuya Yoshizaki, Madoka Takao, Toshitatsu Takao, Yoshinori Morita, Hiroshi Yokozaki, Yuzo Kodama

  Background/Aims: The anastomotic site after distal gastrectomy is the area most affected by duodenogastric reflux. Different reconstruction methods may affect the lesion characteristics and treatment outcomes of remnant gastric cancers at the anastomotic site. We retrospectively investigated the clinicopathologic and endoscopic submucosal dissection outcomes of remnant gastric cancers at the anastomotic site.Methods: We recruited 34 consecutive patients who underwent endoscopic submucosal dissection for remnant gastric cancer at the anastomotic site after distal gastrectomy. Clinicopathology and treatment outcomes were compared between the Billroth II and non-Billroth II groups.Results: The tumor size in the Billroth II group was significantly larger than that in the non-Billroth II group (22 vs. 19 mm; p=0.048). More severe gastritis was detected endoscopically in the Billroth II group (2 vs. 1.33; p=0.0075). Moreover, operation time was longer (238 vs. 121 min; p=0.004) and the frequency of bleeding episodes was higher (7.5 vs. 3.1; p=0.014) in the Billroth II group.Conclusions: Compared to remnant gastric cancers in non-Billroth II patients, those in the Billroth II group had larger lesions with a background of severe remnant gastritis. Endoscopic submucosal dissection for remnant gastric cancers in Billroth II patients involved longer operative times and more frequent bleeding episodes than that in patients without Billroth II.

  The Korean Society of Gastrointestinal Endoscopy, Aug. 2021, Clinical Endoscopy, 55(1) (1), 86 - 94

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Timing of pyloric stenosis and effectiveness of endoscopic balloon dilation after pyloric endoscopic submucosal dissection.

  Hiroshi Takayama, Takashi Toyonaga, Tetsuya Yoshizaki, Hirofumi Abe, Tatsuya Nakai, Chise Ueda, Satoshi Urakami, Hidetoshi Kaku, Yusaku Shimamoto, Kei Matsumoto, Kazunori Tsuda, Hiroya Sakaguchi, Koki Matsuoka, Shinichi Baba, Hiroshi Takihara, Nobuaki Ikezawa, Shinwa Tanaka, Madoka Takao, Toshitatsu Takao, Yoshinori Morita, Yuzo Kodama

  BACKGROUND AND AIM: There have been studies on risk factors for stenosis after pyloric endoscopic submucosal dissection (ESD). However, the most appropriate strategies for the management of cases with these risk factors have not been established. This study aimed to investigate post-ESD management by evaluating the timing of stenosis and the effectiveness of endoscopic balloon dilation (EBD) after pyloric ESD. METHODS: We retrospectively reviewed cases of pyloric ESD. We first reassessed risk factors for stenosis in multivariate analysis and receiver operating characteristic curve and defined patients with the identified risk factors as the risk group. The primary outcome was the timing of stenosis in the risk group assessed by the Kaplan-Meier method. RESULTS: We reviewed 159 cases with pyloric ESD and observed pyloric stenosis in 25 cases. Cases with circumferential mucosal defect ≥ 76% were identified as the risk group. The stenosis-free probability in the risk group was 97% (95% confidence interval [CI]: 79-100%), 94% (95% CI: 76-98%), and 85% (95% CI: 66-93%) on days 7, 14, and 21, respectively. It decreased every week thereafter and did not significantly change after day 56. Twenty-three stenosis cases, except for conservative improvement, including six whole circumferential pyloric ESD cases, were improved by EBD without complications. CONCLUSIONS: Post-ESD stenosis often developed from the third to the eighth week. In all pyloric ESD cases, including whole circumferential pyloric ESD cases, pyloric stenosis was improved following EBD without complications.

  Jun. 2021, Journal of gastroenterology and hepatology, 36(11) (11), 3158 - 3163, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• EFFECTS OF ANTITHROMBOTICS ON BLEEDING AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION FOR GASTRIC CANCER: A NATIONWIDE PROPENSITY SCORE ANALYSIS

  Madoka Takao, Yoshinori Morita, Yasuaki Nagami, Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Naomi Kakushima, Shu Hoteya, Shigetsugu Tsuji, Shusei Fukunaga, Takuto Hikichi, Masakuni Kobayashi, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Mitsushige Sugimoto, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribayashi, Shu Kiyotoki, Katsuhiro Mabe, Hisako Yoshida, Mitsuhiro Fujishiro, Atsushi Masamune, Yasuhiro Fujiwara, Yuzo Kodama

  Jun. 2021, Gastrointestinal Endoscopy,, 93(6) (6), AB62

  [Refereed]


• The risk scoring system for assessing the technical difficulty of endoscopic submucosal dissection in cases of remnant gastric cancer after distal gastrectomy.

  Shinwa Tanaka, Tetsuya Yoshizaki, Yoshinobu Yamamoto, Takayuki Ose, Tsukasa Ishida, Yasuaki Kitamura, Daisuke Obata, Mineo Iwatate, Mikio Fujita, Atsushi Ikeda, Ryusuke Ariyoshi, Fumiaki Kawara, Hirofumi Abe, Toshitatsu Takao, Yoshinori Morita, Yasushi Sano, Eiji Umegaki, Hogara Nishisaki, Takashi Toyonaga, Yuzo Kodama

  BACKGROUND: Endoscopic submucosal dissection (ESD) for remnant gastric cancer (RGC) after distal gastrectomy (DG) is considered technically challenging due to the narrow working space, and severe fibrosis and staples from the previous surgery. Technical difficulties of ESD for RGC after DG have not been thoroughly investigated. This study aimed to develop and validate a risk-scoring system for assessing the technical difficulty of ESD for RGC after DG in a large multicenter cohort. METHODS: We investigated patients who underwent ESD for RGC after DG in 10 institutions between April 2008 and March 2018. A difficult case was defined as ESD lasting ≥ 120 min, involving piecemeal resection, or the occurrence of perforation during the procedure. A risk-scoring system for the technical difficulty of the procedure was developed based on multiple logistic regression analyses, and its performance was internally validated using bootstrapping. RESULTS: A total of 197 consecutive patients with 201 lesions were analyzed. There were 90 and 111 difficult and non-difficult cases, respectively. The scoring model consisted of four independent risk factors and points of risk scores were assigned for each as follows: tumor size > 20 mm: 2 points; anastomosis site: 2 points; suture line: 1 point; and non-expert endoscopist: 2 points. The C-statistics of the scoring system for technical difficulty was 0.72. CONCLUSIONS: We developed a validated risk-scoring model for predicting the technical difficulty of ESD for RGC after DG that can contribute to its safer and more reliable performance.

  Apr. 2021, Surgical endoscopy, 36(2) (2), 1482 - 1489, English, International magazine

  Scientific journal


• 十二指腸表在型腫瘍に対する内視鏡診療(LECS vs EMR vs ESD vs経過観察) 表在型非乳頭部十二指腸上皮性腫瘍に対する腹腔鏡内視鏡合同手術の治療成績

  鷹尾 俊達, 森田 圭紀, 児玉 裕三

  (一社)日本消化器内視鏡学会, Apr. 2021, Gastroenterological Endoscopy, 63(Suppl.1) (Suppl.1), 848 - 848, Japanese


• 進行食道癌に対する食道ステント留置後の食事摂取状況に関する検討

  賀来 英俊, 鷹尾 俊達, 中井 達也, 高山 弘志, 嶋本 有策, 上田 千勢, 津田 一範, 松本 慶, 池澤 伸明, 阪口 博哉, 松岡 晃生, 阿部 洋文, 吉崎 哲也, 鷹尾 まど佳, 森田 圭紀, 豊永 高史, 児玉 裕三

  (一社)日本消化器内視鏡学会, Apr. 2021, Gastroenterological Endoscopy, 63(Suppl.1) (Suppl.1), 910 - 910, Japanese


• 幽門側胃切除後の残胃吻合部の早期胃癌に対する内視鏡的粘膜下層剥離術の再建術式に基づく治療困難性および有効性、安全性の検討

  松本 慶, 鷹尾 俊達, 田中 心和, 森田 圭紀, 豊永 高史, 児玉 裕三

  (一社)日本消化器内視鏡学会, Apr. 2021, Gastroenterological Endoscopy, 63(Suppl.1) (Suppl.1), 956 - 956, Japanese


• Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score.

  Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Naomi Kakushima, Shu Hoteya, Hisashi Doyama, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tomoyuki Koike, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Mitsushige Sugimoto, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribasyashi, Shu Kiyotoki, Katsuhiro Mabe, Tomohiro Nakamura, Naoki Nakaya, Mitsuhiro Fujishiro, Atsushi Masamune

  OBJECTIVE: Bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is a frequent adverse event after ESD. We aimed to develop and externally validate a clinically useful prediction model (BEST-J score: Bleeding after ESD Trend from Japan) for bleeding after ESD for EGC. DESIGN: This retrospective study enrolled patients who underwent ESD for EGC. Patients in the derivation cohort (n=8291) were recruited from 25 institutions, and patients in the external validation cohort (n=2029) were recruited from eight institutions in other areas. In the derivation cohort, weighted points were assigned to predictors of bleeding determined in the multivariate logistic regression analysis and a prediction model was established. External validation of the model was conducted to analyse discrimination and calibration. RESULTS: A prediction model comprised 10 variables (warfarin, direct oral anticoagulant, chronic kidney disease with haemodialysis, P2Y12 receptor antagonist, aspirin, cilostazol, tumour size >30 mm, lower-third in tumour location, presence of multiple tumours and interruption of each kind of antithrombotic agents). The rates of bleeding after ESD at low-risk (0 to 1 points), intermediate-risk (2 points), high-risk (3 to 4 points) and very high-risk (≥5 points) were 2.8%, 6.1%, 11.4% and 29.7%, respectively. In the external validation cohort, the model showed moderately good discrimination, with a c-statistic of 0.70 (95% CI, 0.64 to 0.76), and good calibration (calibration-in-the-large, 0.05; calibration slope, 1.01). CONCLUSIONS: In this nationwide multicentre study, we derived and externally validated a prediction model for bleeding after ESD. This model may be a good clinical decision-making support tool for ESD in patients with EGC.

  Mar. 2021, Gut, 70(3) (3), 476 - 484, English, International magazine

  Scientific journal


• Fibrin glue: Novel submucosal injection agent for endoscopic submucosal dissection.

  Madoka Takao, Yoshitaka Takegawa, Toshitatsu Takao, Hiroya Sakaguchi, Yoshiko Nakano, Shinwa Tanaka, Yoshinori Morita, Takashi Toyonaga, Eiji Umegaki, Hiromu Kutsumi, Yuzo Kodama

  Background and study aims  Adequate mucosal elevation by submucosal injection is crucial for patient safety and efficiency during endoscopic submucosal dissection (ESD). This study aimed to evaluate the efficacy of fibrin glue (FG) as a long-lasting submucosal injection agent and to evaluate the technical feasibility of FG injection for ESD. Materials and methods  To compare the capabilities of different agents in maintaining submucosal evaluation, we injected FG, hyaluronic acid solution, and normal saline into the porcine gastric specimen that was incised into approximately 5 × 5 cm squares. Then, we measured the height of submucosal elevations over time. Moreover, three hypothetical lesions from the resected porcine stomach underwent ESD with FG injection. Thereafter, we conducted macroscopic and histopathologic analyses. Results FG maintained the greatest submucosal elevation among all the injection agents. Three ESD procedures were performed with en bloc resection. Both macroscopic and histopathologic findings showed a thick FG clot on the ulcers. Conclusions  The FG solution can be potentially used as an ESD submucosal injection agent in an in vitro model.

  Mar. 2021, Endoscopy international open, 9(3) (3), E319-E323, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Endoscopic submucosal dissection involving the anal canal presents a risk factor for postoperative stricture.

  Tomoya Sako, Takashi Toyonaga, Yoshiko Nakano, Shinwa Tanaka, Toshitatsu Takao, Shinichi Baba, Hiroshi Takihara, Yoshinori Morita, Eiji Umegaki, Yuzo Kodama

  BACKGROUND: Although postoperative strictures after endoscopic submucosal dissection (ESD) in the rectum are relatively rare, some rectal lesions require resection involving the anal canal, which is a narrow tract comprising squamous epithelium. To the best of our knowledge, no studies have investigated narrow anal canals when evaluating post-ESD strictures. This study aimed to evaluate the impact of resections involving the anal canal on postoperative stricture development. METHODS: Between April 2005 and October 2017, 707 rectal lesions were treated with ESD. We retrospectively investigated 102 lesions that required ≥ 75% circumferential resection. Risk factors for post-ESD stricture and, among patients with strictures, obstructive symptoms, and number of dilation therapies required were investigated. RESULTS: Post-ESD stricture occurred in 18 of 102 patients (17.6%). In the multivariate analysis, circumferential resection ≥ 90% and ESD involving the anal canal (ESD-IAC) were risk factors for postoperative strictures (P ≤ 0.0001 and 0.0115, respectively). Among the patients with strictures, obstructive symptoms were significantly related to anal strictures compared to rectal strictures (100% vs. 27.2%, P = 0.0041). Furthermore, the number of dilation therapies required was significantly greater among patients with anal strictures compared to those with rectal strictures (6.5 times vs. 2.7 times, P = 0.0263). CONCLUSION: Not only circumferential resection ≥ 90% but also ESD-IAC was a significant risk factor for the stricture after rectal ESD. Furthermore, anal strictures were associated with a significantly higher frequency of obstructive symptoms and larger number of required dilation therapies than were rectal strictures.

  Mar. 2021, Surgical endoscopy, 35(3) (3), 1307 - 1316, English, International magazine

  [Refereed]

  Scientific journal


• Feasibility of laparoscopic endoscopic cooperative surgery for non-ampullary superficial duodenal neoplasms: Single-arm confirmatory trial.

  Shingo Kanaji, Yoshinori Morita, Yuta Yamazaki, Yasunori Otowa, Toshitatsu Takao, Shinwa Tanaka, Naoki Urakawa, Masashi Yamamoto, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Takashi Toyonaga, Yuzo Kodama, Yoshihiro Kakeji

  OBJECTIVE: Laparoscopic endoscopic cooperative surgery for duodenal tumors (D-LECS) has been developed to prevent duodenal leakage by reinforcing the endoscopic submucosal dissection site. However, there has been no prospective trial showing the feasibility of D-LECS. Herein, we conducted a single-arm confirmatory trial to evaluate the safety of D-LECS for non-ampullary superficial duodenal neoplasms. METHODS: This prospective single-center single-arm confirmatory trial analyzed patients with non-ampullary superficial duodenal neoplasms who underwent D-LECS. The primary endpoint was the incidence of any postoperative leakage occurring on the duodenal wall within 1 month postoperatively. The planned sample size was 20 patients, considering a threshold of 28% and one-sided alpha value of 5%. RESULTS: Between January 2015 and September 2018, 20 eligible patients were enrolled. Sixteen tumors were located in the second portion, three in the first portion, and one in the third portion of the duodenal region. The median operative time was 225 (134-361) min and the median blood loss was 0 (0-150) mL. Curative resection (R0) with negative margins was achieved in 19 cases. One case of postoperative leakage and one case of bleeding of grade 2 according to the Clavien-Dindo classification were observed in this series. The median duration of postoperative hospital stay was 9 (5-12) days. No local recurrence was observed in any patient during the median follow-up of 15.0 (12.0-38.0) months. CONCLUSIONS: This trial confirmed the safety and feasibility of D-LECS for non-ampullary superficial duodenal neoplasms with respect to the low incidence of postoperative duodenal leakage.

  Mar. 2021, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 33(3) (3), 373 - 380, English, International magazine

  [Refereed]

  Scientific journal


• Rebleeding in patients with delayed bleeding after endoscopic submucosal dissection for early gastric cancer.

  Minami Hashimoto, Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Yohei Yabuuchi, Shu Hoteya, Hisashi Doyama, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Mitsushige Sugimoto, Mitsuhiro Fujishiro, Atsushi Masamune, Hiromasa Ohira

  OBJECTIVES: Delayed bleeding is a major adverse event in endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). Some patients may experience rebleeding after successful hemostasis for delayed bleeding, yet the details of rebleeding remain unclear. We aimed to clarify the frequency and risk factors of rebleeding. METHODS: Among 11,452 patients who underwent ESD for EGC at 33 institutions in Japan between 2013 and 2016, we analyzed 489 patients showing delayed bleeding. The rate of rebleeding was investigated. Subsequently, 15 candidate variables were evaluated for their influence on the risk of rebleeding via logistic regression analysis. RESULTS: Rebleeding occurred in 11.2% (55/489) of the enrolled patients. Multivariate analysis revealed that warfarin [odds ratio (OR), 2.71; 95% confidence interval (CI), 1.26-5.84] and a resection size >40 mm (OR, 1.99; 95% CI, 1.08-3.67) were independent risk factors for rebleeding. In the analysis of the management of warfarin after index bleeding, only warfarin discontinuation (OR, 3.66; 95% CI, 1.37-9.78) was significantly associated with rebleeding in comparison with no use of warfarin. However, many rebleeding events (75.0%) occurred following the resumption of warfarin. The rebleeding rate during discontinuation status and that in taking warfarin (continuation or resumption) were 6.1% and 20.0%, respectively. CONCLUSIONS: Rebleeding was not a rare event in patients experiencing delayed bleeding after ESD for EGC. In addition to having a resection size >40 mm, warfarin usage placed patients at high risk for rebleeding, especially at the timing of its resumption following discontinuation as well as its continuation.

  Feb. 2021, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 33(7) (7), 1120 - 1130, English, International magazine

  Scientific journal


• 小腸多発血管異形成に対するダブルバルーン内視鏡、およびアルゴンプラズマ凝固術後に、遅発性小腸穿孔を来たした一例

  吉治 誠, 松本 慶, 鷹尾 俊達, 岡本 典大, 宮崎 はる香, 松岡 晃生, 竹中 春香, 大井 充, 森田 圭紀, 豊永 高史, 児玉 裕三

  日本消化器病学会-近畿支部, Feb. 2021, 日本消化器病学会近畿支部例会プログラム・抄録集, 114回, 72 - 72, Japanese


• 消化管内視鏡治療における抗血栓薬の取り扱い 早期胃癌ESD後出血予測モデル simple modelとBEST-J scoreの比較

  八田 和久, 辻 陽介, 由雄 敏之, 角嶋 直美, 布袋屋 修, 土山 寿志, 永見 康明, 引地 拓人, 小林 雅邦, 森田 圭紀, 井口 幹崇, 富田 英臣, 井上 拓也, 三上 達也, 波佐谷 兼慶, 岡本 健志, 松村 倫明, 藤城 光弘, 正宗 淳, FIGHT-Japan study group

  (一社)日本消化管学会, Jan. 2021, 日本消化管学会雑誌, 5(Suppl.) (Suppl.), 184 - 184, Japanese


• Efficacy of the Envelope Method in Applying Polyglycolic Acid Sheets to Post-Endoscopic Submucosal Dissection Ulcers in Living Pigs.

  Hiroya Sakaguchi, Toshitatsu Takao, Yoshitaka Takegawa, Yuki Koga, Kazunori Yamanaka, Masataka Sagata, Shinwa Tanaka, Yoshinori Morita, Takashi Toyonaga, Yuzo Kodama

  BACKGROUND/AIMS: Application of polyglycolic acid (PGA) sheets using fibrin glue in post-endoscopic submucosal dissection (ESD) ulcers to prevent bleeding has been reported to be difficult with the conventional delivery method because of gravity. This study assessed the usefulness of the envelope-based delivery system with and against gravity in living pigs. METHODS: PGA sheets were applied on post-ESD ulcers with and against gravity six times each using the conventional and envelope methods, respectively. The PGA sheet delivery time and the endoscopic and histological findings of the treated ulcer floors were compared. RESULTS: With gravity, the median PGA sheet application time was 1.00 (0.68-1.30) min/cm2 and 0.32 (0.18-0.52) min/cm2 with the conventional and envelope techniques (p=0.002), respectively, and against gravity, it was 1.20 (1.13-1.63) min/cm2 and 0.50 (0.39-0.58) min/cm2 (p=0.002), respectively. Against gravity, the endoscopic and histological findings revealed that the conventional group had insufficient fixation of the PGA sheets, but the envelope groups had sufficient fixation. The results with gravity were similar between the groups. CONCLUSION: The envelope method makes it possible to deliver PGA sheets to the stomach quickly and cover ulcers appropriately both with and against gravity in living pigs.

  Jan. 2021, Clinical endoscopy, 54(1) (1), 64 - 72, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Influence of anticoagulants on the risk of delayed bleeding after gastric endoscopic submucosal dissection: a multicenter retrospective study.

  Hideomi Tomida, Toshiyuki Yoshio, Kimihiro Igarashi, Yoshinori Morita, Ichiro Oda, Takuya Inoue, Takuto Hikichi, Tetsuya Sumiyoshi, Hisashi Doyama, Yosuke Tsuji, Jun Nishikawa, Waku Hatta, Tatsuya Mikami, Mikitaka Iguchi, Kazuki Sumiyama, Katsumi Yamamoto, Kazuya Kitamura, Shiko Kuribayashi, Atsushi Yanagitani, Toshio Uraoka, Tomoyuki Yada, Kenkei Hasatani, Koichiro Kawaguchi, Tomoki Fujita, Tsutomu Nishida, Yoichi Hiasa, Mitsuhiro Fujishiro

  BACKGROUND AND AIMS: Delayed bleeding after gastric endoscopic submucosal dissection (ESD) in patients receiving anticoagulants remains an unpreventable adverse event. Although direct-acting oral anticoagulants (DOACs) have superior efficacy in preventing thromboembolism, their effects on the occurrence of delayed bleeding remain unclear. This study aimed to elucidate the clinical effect of DOACs on delayed bleeding after gastric ESD. PATIENTS AND METHODS: We retrospectively examined 728 patients who received anticoagulants and were treated for gastric neoplasms with ESD in 25 institutions across Japan. Overall, 261 patients received DOACs, including dabigatran (92), rivaroxaban (103), apixaban (45) and edoxaban (21), whereas 467 patients were treated with warfarin. RESULTS: Delayed bleeding occurred in 14% of patients taking DOACs, which was not considerably different in patients receiving warfarin (18%). Delayed bleeding rate was significantly lower in patients receiving dabigatran than in those receiving warfarin and lower than that observed for other DOACs. Multivariate analysis showed that age ≥ 65, receiving multiple antithrombotic agents, resection of multiple lesions and lesion size ≥ 30 mm were independent risk factors, and that discontinuation of anticoagulants was associated with a decreased risk of bleeding. In multivariate analysis among patients taking DOACs, dabigatran therapy was associated with a significantly lower risk of delayed bleeding. CONCLUSIONS: The effects of DOACs on delayed bleeding varied between agents, but dabigatran therapy was associated with the lowest risk of delayed bleeding. Switching oral anticoagulants to dabigatran during the perioperative period could be a reasonable option to reduce the risk of delayed bleeding after gastric ESD.

  Jan. 2021, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 24(1) (1), 179 - 189, English, Domestic magazine

  Scientific journal


• Helicobacter pylori未感染胃に生じたラズベリー様腺窩上皮型胃癌の1例

  堀谷 晋, 松岡 晃生, 鷹尾 俊達, 田中 心和, 阿部 洋文, 森田 圭紀, 豊永 高史, 児玉 裕三

  日本消化器内視鏡学会-近畿支部, Dec. 2020, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 105回, 60 - 60, Japanese


• PGAシートにて胃ESD後遅発性穿孔を閉鎖し得た一例

  山本 顕, 賀来 英俊, 鷹尾 俊達, 中井 達也, 高山 弘志, 嶋本 有策, 上田 千勢, 津田 一範, 松本 慶, 池澤 伸明, 阪口 博哉, 松岡 晃生, 阿部 洋文, 吉崎 哲也, 鷹尾 まど佳, 森田 圭紀, 豊永 高史, 児玉 裕三

  日本消化器内視鏡学会-近畿支部, Dec. 2020, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 105回, 60 - 60, Japanese


• Reasons for Diagnostic Failure in Forty-Five Consecutive Mucosal Cutting Biopsy Examinations of Gastric Subepithelial Tumors.

  Yoshiko Nakano, Toshitatsu Takao, Yoshinori Morita, Shinwa Tanaka, Takashi Toyonaga, Eiji Umegaki, Yuzo Kodama

  BACKGROUND/AIMS: Mucosal cutting biopsy (MCB) is useful for the histopathological diagnosis of gastric subepithelial tumors (SETs). However, there is little information on cases in which MCB did not establish a diagnosis. In the current study, we aimed to investigate the characteristics of cases in which MCB was unsuccessful. METHODS: Cases in which MCB was used to histopathologically diagnose gastric SETs at Kobe University Hospital between August 2012 and October 2018 were retrospectively reviewed. RESULTS: Forty-five cases in which MCB was used to diagnose 43 gastric SETs in 43 patients were analyzed. The median tumor size was 20 mm (range, 8-50 mm). Pathological examinations resulted in definitive and suspected diagnoses and no diagnosis in 29 (gastrointestinal stromal tumor: n=17, leiomyoma: n=7, aberrant pancreas: n=3, others: n=2), 6, and 10 cases, respectively. Failure to expose the tumor according to retrospective examinations of endoscopic images was significantly associated with no diagnosis. Other possible explanations included a less elevated tumor, biopsy of the surrounding field instead of the tumor due to the mobility, and poor endoscope maneuverability due to the tumor being close to the cardia. CONCLUSION: Clear exposure of gastric SETs during MCB may improve the diagnostic rate of such examinations.

  Sep. 2020, Clinical endoscopy, 53(5) (5), 575 - 582, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Early gastric cancer involving a pure enteroblastic differentiation component that was curatively resected via endoscopic submucosal dissection.

  Nobuaki Ikezawa, Shinwa Tanaka, Hidetoshi Kaku, Toshitatsu Takao, Yoshinori Morita, Takashi Toyonaga, Masato Komatsu, Hiroshi Yokozaki, Tomoo Ito, Yuzo Kodama

  Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a very rare variant of alpha-fetoprotein-producing gastric cancer (AFPGC). GAED is histologically characterized by cuboidal or columnar cells, which resemble those found in the primitive gut and have clear cytoplasm. In previously reported cases, GAED exhibit more aggressive behavior, as well as AFPGC, than conventional gastric cancer, such as marked lymphovascular invasion, lymph node metastasis, and liver metastasis. And also GAED was usually located in a deep mucosal layer and was covered by a conventional adenocarcinoma (CA) component. Based on these findings, GAED is considered to develop from CA during the process of tumor invasion and proliferation. We present a very rare case of early-stage GAED achieved curatively resected via endoscopic submucosal dissection, in which the lesion was composed of a pure enteroblastic differentiation component without a CA component.

  Aug. 2020, Clinical journal of gastroenterology, 13(4) (4), 512 - 516, English, Domestic magazine

  [Refereed]

  Scientific journal


• DERIVATION AND EXTERNAL VALIDATION OF A PREDICTION MODEL (BEST-J SCORE) OF BLEEDING AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EARLY GASTRIC CANCER

  Masakuni Kobayashi, Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Naomi Kakushima, Shu Hoteya, Hisashi Doyama, Yasuaki Nagami, Takuto Hikichi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tomoyuki Koike, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Mitsushige Sugimoto, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribayashi, Shu Kiyotoki, Katsuhiro Mabe, Tomohiro Nakamura, Naoki Nakaya, Mitsuhiro Fujishiro, Atsushi Masamune

  Jun. 2020, Gastrointestinal Endoscopy,, 91(6) (6), AB585 - AB586

  [Refereed]


• Development and validation of an endoscopic submucosal dissection video assessment tool.

  Madoka Takao, Elif Bilgic, Pepa Kaneva, Kevin Waschke, Satoshi Endo, Yoshiko Nakano, Fumiaki Kawara, Shinwa Tanaka, Tsukasa Ishida, Yoshinori Morita, Takashi Toyonaga, Eiji Umegaki, Yuzo Kodama, Gerald M Fried

  BACKGROUND: Despite a need for assessment of endoscopic submucosal dissection (ESD) skills in order to track progress and determine competence, there is no structured measure of assessing competency in ESD performance. The present study aims to develop and examine validity evidence for an assessment tool to evaluate the recorded performance of ESD for gastric neoplasms. METHODS: The ESD video assessment tool (EVAT) was systematically developed by ESD experienced endoscopists. The EVAT consists of a 25-item global rating scale and 3-item checklist to assess competencies required to perform ESD. Five unedited videos were each evaluated by 2-blinded experienced ESD endoscopists to assess inter-rater reliability using intraclass correlation coefficients (ICC). Seventeen unedited videos in total were rated by 3 blinded experienced ESD endoscopists. Validity evidence for relationship to other variables was examined by comparing scores of inexperienced (fellows) and experienced endoscopists (attending staff), and by evaluating the relationship between the EVAT scores and ESD case experience. Internal consistency was evaluated using Cronbach's alpha. RESULTS: The inter-rater reliability for the total score was high at 0.87 (95% confidence interval 0.11 to 0.99). The total score [median, interquartile range (IQR)] was significantly different between the inexperienced (71, 63-77) and experienced group (95, 91-97) (P = 0.005). The total scores demonstrated high correlation with the number of ESD cases (Spearman's ρ = 0.79, P < 0.01). The internal consistency was 0.97. CONCLUSIONS: This study provides preliminary validity evidence for the assessment of video-recorded ESD performances for gastric neoplasms using EVAT.

  Jun. 2020, Surgical endoscopy, 35(6) (6), 2671 - 2678, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• The number and size of Lugol-voiding areas were reduced by pneumatic dilation in a patient with achalasia and esophageal cancer.

  Shinwa Tanaka, Hirofumi Abe, Ryusuke Ariyoshi, Hiroya Sakaguchi, Taro Oshikiri, Tetsu Nakamura, Yoshiko Nakano, Yoshinori Morita, Takashi Toyonaga, Eiji Umegaki, Hiroshi Yokozaki, Yoshihiro Kakeji, Yuzo Kodama

  Apr. 2020, JGH open : an open access journal of gastroenterology and hepatology, 4(2) (2), 309 - 311, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Enhancement of the safety and efficacy of colorectal endoscopic submucosal dissection using a CO2 laser.

  Takuma Noguchi, Hisanao Hazama, Takahiro Nishimura, Yoshinori Morita, Kunio Awazu

  Endoscopic submucosal dissection (ESD) has been at the forefront of international attention as a less invasive treatment for early gastrointestinal cancer. Currently, ESD involves the use of an electrosurgical knife for mucosal incision and subsequent submucosal dissection. However, it has been reported that perforation occurs in approximately 5% of cases. To enhance tissue selectivity with this modality, we focused on applying a laser to ESD (laser ESD). A CO2 laser was chosen as the surgical knife because the saline or sodium hyaluronate solution injected into the submucosal layer during the current ESD procedure has a high absorption coefficient at the wavelength of the CO2 laser. Thus, the purpose of this study is to quantitatively clarify the safety and efficacy of laser ESD for the colon. First, we validated a porcine colon as a model of the human colon in terms of optical and thermal properties. Next, ex vivo experiments on the safety and efficacy of laser ESD were performed. In ex vivo experiments using extracted porcine colon tissue, an incision depth of 0.5-1.0 mm was obtained without thermal damage to the muscle layer when the power density was set at 17, 22, or 28 W/mm2. In addition, less thermal damage was observed in tissue incised with this method compared with electrosurgical knives. These results might be explained by the strong absorption of the CO2 laser by the saline injected into the submucosa. Therefore, laser ESD is expected to be a safer method for the treatment of early colon cancer.

  Mar. 2020, Lasers in medical science, 35(2) (2), 421 - 427, English, International magazine

  [Refereed]

  Scientific journal


• Fluorescence detection of deep intramucosal cancer excited by green light for photodynamic diagnosis using protoporphyrin IX induced by 5-aminolevulinic acid: an ex vivo study.

  Daisuke Ihara, Hisanao Hazama, Takahiro Nishimura, Yoshinori Morita, Kunio Awazu

  SIGNIFICANCE: The diagnostic depth of photodynamic diagnosis (PDD) for gastric cancer with protoporphyrin IX (PpIX) is limited, which leads to missing intramucosal cancers in screening and surgery. AIM: The reason is that the excitation light, whose wavelength is determined by the highest absorption peak of PpIX (∼405  nm), is strongly attenuated by mucosal tissues. We investigated an excitation wavelength that can extend the diagnostic depth of PpIX fluorescence at the mucosal subsurface. APPROACH: By calculating the depth-dependent intensity of the excitation light in porcine gastric mucosa for each wavelength, relationships among the wavelength, fluorophore depth, and fluorescence intensity were assessed and fluorescence images of PpIX pellets located at different fluorophore depths were compared experimentally by changing the excitation wavelength. RESULTS: The numerical calculation showed that a 505-nm excitation light provided the highest fluorescence intensities at a fluorophore depth deeper than 1.1 mm. In the fluorescence observation, the fluorescence intensities at fluorophore depths of 0 and 1.0 mm at 405 nm were 5.4  ×  103 and 1.0  ×  103  arb. units, whereas those at 505 nm were 5.3  ×  101 and 1.9  ×  102  arb. units, respectively. CONCLUSION: The experimental results suggest that the diagnosis depth of PDD with PpIX for intramucosal cancer can be extended by 505-nm excitation light.

  Mar. 2020, Journal of biomedical optics, 25(6) (6), 1 - 13, English, International magazine

  [Refereed]

  Scientific journal


• Feasibility and Safety of Endoscopic Submucosal Dissection for Recurrent Rectal Lesions that after Transanal Endoscopic Microsurgery: A Case Series.

  Nobuaki Ikezawa, Takashi Toyonaga, Shinwa Tanaka, Yoshiko Nakano, Tsukasa Ishida, Tomoatsu Yoshihara, Masanao Uraoka, Yoshinori Morita, Noriko Suzuki, Amyn Haji, Yuzo Kodama

  Feb. 2020, Digestion, 102(3) (3), 1 - 7, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Novel per-oral endoscopic myotomy method preserving oblique muscle using two penetrating vessels as anatomic landmarks reduces postoperative gastroesophageal reflux.

  Shinwa Tanaka, Takashi Toyonaga, Fumiaki Kawara, Daisuke Watanabe, Namiko Hoshi, Hirohumi Abe, Ryusuke Ariyoshi, Yoshiko Ohara, Toshitatsu Takao, Yoshinori Morita, Eiji Umegaki, Yuzo Kodama

  Dec. 2019, Journal of gastroenterology and hepatology, 34(12) (12), 2158 - 2163, English, International magazine

  [Refereed]

  Scientific journal


• Efficacy of Endoscopic Resection and Selective Chemoradiotherapy for Stage I Esophageal Squamous Cell Carcinoma.

  Keiko Minashi, Keiji Nihei, Junki Mizusawa, Kohei Takizawa, Tomonori Yano, Yasumasa Ezoe, Tomohiro Tsuchida, Hiroyuki Ono, Toshiro Iizuka, Noboru Hanaoka, Ichiro Oda, Yoshinori Morita, Masahiro Tajika, Junko Fujiwara, Yoshinobu Yamamoto, Chikatoshi Katada, Shinichiro Hori, Hisashi Doyama, Tsuneo Oyama, Hiroko Nebiki, Kenji Amagai, Yutaro Kubota, Ken Nishimura, Nozomu Kobayashi, Takuto Suzuki, Kingo Hirasawa, Toshihisa Takeuchi, Haruhiko Fukuda, Manabu Muto

  BACKGROUND & AIMS: Esophagectomy is the standard treatment for stage I esophageal squamous cell carcinoma (ESCC). We conducted a single-arm prospective study to confirm the efficacy and safety of selective chemoradiotherapy (CRT) based on findings from endoscopic resection (ER). METHODS: We performed a prospective study of patients with T1b (SM1-2) N0M0 thoracic ESCC from December 2006 through July 2012; 176 patients underwent ER. Based on the findings from ER, patients received the following: no additional treatment for patients with pT1a tumors with a negative resection margin and no lymphovascular invasion (group A); prophylactic CRT with 41.4 Gy delivered to locoregional lymph nodes for patients with pT1b tumors with a negative resection margin or pT1a tumors with lymphovascular invasion (group B); or definitive CRT (50.4 Gy) with a 9-Gy boost to the primary site for patients with a positive vertical resection margin (group C). Chemotherapy comprised 5-fluorouracil and cisplatin. The primary end point was 3-year overall survival in group B, and the key secondary end point was 3-year overall survival for all patients. If lower limits of 90% confidence intervals for the primary and key secondary end points exceeded the 80% threshold, the efficacy of combined ER and selective CRT was confirmed. RESULTS: Based on the results from pathology analysis, 74, 87, and 15 patients were categorized into groups A, B, and C, respectively. The 3-year overall survival rates were 90.7% for group B (90% confidence interval, 84.0%-94.7%) and 92.6% in all patients (90% confidence interval, 88.5%-95.2%). CONCLUSIONS: In a prospective study of patients with T1b (SM1-2) N0M0 thoracic ESCC, we confirmed the efficacy of the combination of ER and selective CRT. Efficacy is comparable to that of surgery, and the combination of ER and selective CRT should be considered as a minimally invasive treatment option. UMIN-Clinical Trials Registry no.: UMIN000000553.

  Aug. 2019, Gastroenterology, 157(2) (2), 382 - 390, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effective treatment improves the body composition of patients with esophageal motility disorders.

  Hirofumi Abe, Shinwa Tanaka, Fumiaki Kawara, Takashi Toyonaga, Ryusuke Ariyoshi, Yoshiko Nakano, Hiroya Sakaguchi, Yoshinori Morita, Eiji Umegaki, Yuzo Kodama

  Aug. 2019, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 32(8) (8), English, International magazine

  [Refereed]

  Scientific journal


• Self-study of the non-extension sign in an e-learning program improves diagnostic accuracy of invasion depth of early gastric cancer.

  Minoru Kato, Noriya Uedo, Takashi Nagahama, Kenshi Yao, Hisashi Doyama, Shigetsugu Tsuji, Takuji Gotoda, Takuji Kawamura, Masahide Ebi, Katsumi Yamamoto, Tomofumi Akasaka, Hajime Takatori, Osamu Handa, Takuji Akamatsu, Jun Nishikawa, Takuto Hikichi, Takeshi Yamashina, Akira Imoto, Yoko Kitamura, Tatsuya Mikami, Tomoyuki Koike, Shuichi Ohara, Shinji Kitamura, Tatsuya Yamaguchi, Tetsu Kinjo, Taro Inoue, Sho Suzuki, Akihiro Kaneko, Kingo Hirasawa, Kyosuke Tanaka, Takahiro Kotachi, Kazuhiro Miwa, Yosuke Toya, Shoichi Kayaba, Atsushi Ikehata, Shinya Minami, Kazuhiro Mizukami, Hirohisa Oya, Nobuyuki Ara, Yasushi Fukumoto, Takuya Komura, Toshiyuki Yoshio, Ryutaro Morizono, Kenji Yamazaki, Yuichi Shimodate, Kohei Yamanouchi, Noboru Kawata, Masayuki Kumagai, Yoshinori Sato, Kiyotaka Umeki, Daisuke Kawai, Tokuma Tanuma, Maiko Kishino, Jun Konishi, Tetsuya Sumiyoshi, Shohei Oka, Mitsuhiro Kono, Takeshi Sakamoto, Yohei Horikawa, Motoki Ohyauchi, Keiichi Hashiguchi, Yohei Waseda, Toyotaka Kasai, Hiroyuki Aoyagi, Hirokazu Oyamada, Masakuni Shoji, Shu Kiyotoki, Sho Asonuma, Shunsuke Orikasa, Chika Akaishi, Yasuaki Nagami, Satoshi Nakata, Fumiyo Iida, Tatsuma Nomura, Kei Tominaga, Kohei Oka, Yoshinori Morita, Haruhisa Suzuki, Keiji Ozeki, Shiko Kuribayashi, Yoichi Akazawa, Sho Sasaki, Tetsuhiko Mikami, Goro Miki, Tatsushi Sano, Hiro Satoh, Munetaka Nakamura, Wataru Iwai, Hideki Tawa, Masafumi Wada, Daisuke Yoshimura, Yasuhiro Hisanaga, Toshio Shimokawa, Hideki Ishikawa

  Background and study aims  We developed an e-learning program for endoscopic diagnosis of invasion depth of early gastric cancer (EGC) using a simple diagnostic criterion called non-extension sign, and the contribution of self-study quizzes to improvement of diagnostic accuracy was evaluated. Methods  We conducted a prospective randomized controlled study that recruited endoscopists throughout Japan. After completing a pretest, the participants watched video lectures and undertook post-test 1. The participants were then randomly allocated to either the self-study or non-self-study group, and participants in the first group completed the self-study program that comprised 100-case quizzes. Finally, participants in both groups undertook post-test 2. The primary endpoint was the difference in post-test 2 scores between the groups. The perfect score for the tests was set as 100 points. Results  A total of 423 endoscopists completed the pretest and were enrolled. Post-test 1 was completed by 415 endoscopists and 208 were allocated to the self-study group and 207 to the non-self-study group. Two hundred and four in the self-study group and 205 in the non-self-study group were included in the analysis. Video lectures improved the mean score of post-test 1 from 72 to 77 points. Participants who completed the self-study quizzes showed significantly better post-test 2 scores compared with the non-self-study group (80 vs. 76 points, respectively, P  < 0.0001). Conclusions  Our e-learning program showed that self-study quizzes consolidated knowledge of the non-extension sign and improved diagnostic ability of endoscopists for invasion depth of EGC.

  Jul. 2019, Endoscopy international open, 7(7) (7), E871-E882, English, International magazine

  [Refereed]

  Scientific journal


• New Development for Safer Endoscopic Submucosal Dissection using the Carbon Dioxide (CO2) Laser (Secondary publication).

  Yoshinori Morita, Ryusuke Ariyoshi, Given-Names Norihiro Honda, Hisanao Hazama, Yuzo Kodama, Kunio Awazu

  Jun. 2019, Laser therapy, 28(2) (2), 89 - 96, English, Domestic magazine

  [Refereed]

  Scientific journal


• Endoscopic plombage with polyglycolic acid sheets and fibrin glue for gastrointestinal fistulas.

  Yoshiko Nakano, Toshitatsu Takao, Yoshinori Morita, Hiroya Sakaguchi, Shinwa Tanaka, Tsukasa Ishida, Takashi Toyonaga, Eiji Umegaki, Yuzo Kodama

  BACKGROUND AND STUDY AIMS: Gastrointestinal (GI) fistulas arise as adverse events of GI surgery and endoscopic treatment as well as secondary to underlying diseases, such as ulceration and pancreatitis. Until a decade ago, they were mainly treated surgically or conservatively. Bioabsorbable polyglycolic acid (PGA) sheets and fibrin glue, which are commonly used in surgical procedures, have also recently been used in endoscopic procedures for the closure of GI defects. However, there have only been few case reports about successful experiences with this approach. There have not been any case-series studies investigating the strengths and weaknesses of such PGA sheet-based treatment. In this study, we evaluated the clinical effectiveness of using PGA sheets to close GI fistulas. PATIENTS AND METHODS: Cases in which patients underwent endoscopic filling with PGA sheets and fibrin glue for GI fistulas at Kobe University Hospital between January 2013 and April 2018 were retrospectively reviewed. RESULTS: A total of 10 cases were enrolled. They included fistulas due to leakage after GI surgery, aortoesophageal/bronchoesophageal fistulas caused by chemoradiotherapy, or severe acute pancreatitis. The fistulas were successfully closed in 7 cases (70%). The unsuccessful cases involved a fistula due to leakage after surgical esophagectomy and bronchoesophageal fistulas due to chemoradiotherapy or severe acute pancreatitis. Unsuccessful treatment was related to fistula epithelization. CONCLUSION: Endoscopic plombage with PGA sheets and fibrin glue could be a promising therapeutic option for GI fistulas.

  Jun. 2019, Surgical endoscopy, 33(6) (6), 1795 - 1801, English, International magazine

  [Refereed]

  Scientific journal


• Recurrence of adenoma after curative endoscopic submucosal dissection for a rectal intramucosal adenocarcinoma in adenoma.

  Yoshiko Nakano, Takashi Toyonaga, Eisei Nishino, Taro Inoue, Isato Shinjo, Hajime Han-No, Shinwa Tanaka, Yoshinori Morita, Eiji Umegaki, Yuzo Kodama

  Background and study aims  A 71-year-old female underwent endoscopic submucosal dissection (ESD) for a subcircumferential lateral-spreading rectal tumor. Pathological examination showed an intramucosal adenocarcinoma in villous adenoma (size: 155 × 140 mm), which had been curatively resected with negative margins. However, follow-up colonoscopy revealed a tumor at the ulcer scar site, which soon grew into a circumferential lesion. Nineteen months after the first ESD procedure, additional ESD was performed for the recurrent lesion, which was resected en bloc without any adverse events, although severe fibrosis was noted in the submucosa. Pathological examination revealed a villous adenoma similar to the primary lesion with negative margins, but tumor cell nests were also present in the submucosa, which implied that tumor cell implantation had occurred during the first ESD. The post-ESD ulcer bed was subjected to argon plasma coagulation to prevent tumor recurrence after confirmation of the pathological results. There have not been any signs of recurrence during 9 years of follow-up.

  Apr. 2019, Endoscopy international open, 7(4) (4), E621-E624, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Clinical impact of peroral endoscopic myotomy for esophageal motility disorders on esophageal muscle layer thickness.

  Daisuke Watanabe, Shinwa Tanaka, Fumiaki Kawara, Hirohumi Abe, Ryusuke Ariyoshi, Yoshiko Nakano, Toshitatsu Takao, Yoshinori Morita, Takashi Toyonaga, Eiji Umegaki, Yuzo Kodama

  Background and study aims  Previously, we reported that esophageal muscle layer thickness was associated with technical complexity of peroral endoscopic myotomy (POEM). However, there are no data regarding the mid-term effects of POEM procedures on esophageal muscle layer thickness. Therefore, we conducted this study to elucidate mid-term effects of POEM procedures, and to examine whether postoperative changes in esophageal muscle layer thickness were related to particular clinico-pathological features in patients with esophageal motility disorders. Patients and methods  Seventy-four consecutive patients with esophageal motility disorders who underwent POEM at Kobe University Hospital from April 2015 to December 2016 were prospectively recruited into this study. First, we investigated the esophageal muscle layer thickness values obtained at 1 year after POEM. Second, we evaluated the effects of a reduction in muscle layer thickness on various clinico-pathological features. Results  At 1 year after POEM, mean thickness of the inner circular muscle at 0 cm, 5 cm, and 10 cm from the esophagogastric junction was 1.06 ± 0.45 mm, 0.99 ± 0.36 mm, and 0.97 ± 0.44 mm, respectively. Among all sites, muscle layer thickness had significantly decreased after POEM. However, univariate logistic regression analysis demonstrated that no clinical factors were associated with esophageal muscle layer thickness after POEM procedure. Conclusions  We demonstrated for the first time that thickness of the esophageal muscle layer was significantly decreased after POEM. This result reveals that changes in esophageal muscle layer thickness caused by esophageal motility disorders are reversible.

  Apr. 2019, Endoscopy international open, 7(4) (4), E525-E532, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Defining competencies for endoscopic submucosal dissection (ESD) for gastric neoplasms.

  Madoka Takao, Elif Bilgic, Kevin Waschke, Pepa Kaneva, Satoshi Endo, Yoshiko Nakano, Shinwa Tanaka, Yoshinori Morita, Takashi Toyonaga, Eiji Umegaki, Yuzo Kodama, Gerald M Fried

  Apr. 2019, Surgical endoscopy, 33(4) (4), 1206 - 1215, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Successful treatment of an esophageal perforation that occurred during endoscopic submucosal dissection for esophageal cancer using polyglycolic acid sheets and fibrin glue.

  Umaporn Seehawong, Yoshinori Morita, Yoshiko Nakano, Takehiro Iwasaki, Chonlada Krutsri, Hiroya Sakaguchi, Tomoya Sako, Toshitatsu Takao, Shinwa Tanaka, Takashi Toyonaga, Eiji Umegaki, Yuzo Kodama

  A 74-year-old female, who was diagnosed with superficial esophageal cancer, underwent endoscopic submucosal dissection (ESD) at another hospital, but a perforation occurred during the procedure. The perforation was closed with endoscopic clips, and the ESD was halted. The patient was referred to our hospital, and ESD was retried. There was severe fibrosis around the lesion, and injections into the submucosal layer were difficult. In addition, it was not possible to identify the submucosal layer, and making an oral-side incision caused a large perforation along the incision line. As continuing the submucosal dissection with an endoknife was considered difficult, the lesion was finally resected with hybrid ESD using a snare. The perforation was closed using polyglycolic acid (PGA) sheets and fibrin glue. Endoscopy performed 6 days later showed that the defect had been closed, and no contrast leakage was detected. Follow-up endoscopy conducted 3 months after the ESD showed ulcer healing at the dissection site and scar formation, but no residual tumor or esophageal stricture was noted. Our experience suggests that the use of PGA sheets with fibrin glue is a feasible, safe, and effective way of treating large esophageal perforations during ESD.

  Feb. 2019, Clinical journal of gastroenterology, 12(1) (1), 29 - 33, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• 【胃拡大内視鏡が変えたclinical practice】 拡大内視鏡が早期胃癌の診断をどう変えたか スクリーニング(拾い上げ診断) 同時性・異時性多発胃癌の診断における拡大内視鏡の有用性と問題点

  Morita Yoshinori, 中野佳子, 田中心和, 豊永高史, 梅垣英次, 児玉裕三

  (株)医学書院, Oct. 2018, 胃と腸, 53(11) (11), 1455 - 1461, Japanese


• Polypoid nodule scar after gastric endoscopic submucosal dissection: results from a multicenter study.

  Vitor Arantes, Noriya Uedo, Yoshinori Morita, Takashi Toyonaga, Yoshiko Nakano, Moises Salgado Pedrosa, Ichiro Oda, Yutaka Saito, Haruhisa Suzuki, Katsumi Yamamoto, Yu Sato, Peter V Draganov

  Background and study aims  A post-endoscopic submucosal dissection (ESD) scar is expected to look homogeneous, however, some patients develop benign polypoid nodule scar (PNS). Incidence of PNS is unknown, yet these scars have direct clinical implications because they may render evaluation of post-ESD neoplastic recurrence difficult. Therefore, we reviewed the clinical experience of 5 ESD referral centers and evaluated their PNS incidence and clinical management. Patients and methods  This was a retrospective multicenter case series enrolling patients that underwent R0, curative gastric ESD from 2003 to 2015 in 5 academic centers. PNS was defined as ESD site nodularity with hyperplastic or regenerative tissue histology. Results  A total of 2275 patients underwent gastric ESD with endoscopy control and 28 patients (18 men/10 women) developed PNS for overall incidence of 1.2 %. Incidence of PNS ranged from 0.15 % to 11.4 % between centers. All patients that developed PNS had primary neoplastic lesions located in the distal stomach. Considering only lesions situated in the antrum (n = 912), incidence of PNS was 3.1 %. After mean follow-up of 43 months (range 6 - 192), no malignant recurrence in the PNS has been identified. In five patients (17.8 %) PNS disappeared after a mean of 18 months. Conclusion  PNS occurs exclusively after ESD in the distal stomach in approximately 3.1 % of patients. Although PNS appearance can be concerning, no malignant recurrence was observed after curative R0 resection. Therefore, PNS should be viewed as a benign alteration that does not require any type of intervention, other than endoscopic surveillance.

  Oct. 2018, Endoscopy international open, 6(10) (10), E1198-E1203 - E1203, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A case of Jackhammer esophagus caused by eosinophilic esophagitis in which per-oral endoscopic myotomy resulted in symptom improvement.

  Shinwa Tanaka, Takashi Toyonaga, Fumiaki Kawara, Daisuke Watanabe, Namiko Hoshi, Hirohumi Abe, Ryusuke Ariyoshi, Yoshiko Ohara, Tsukasa Ishida, Toshitatsu Takao, Yoshinori Morita, Eiji Umegaki

  A 73-year-old female with a 6-month history of progressive dysphagia and chest pain was referred to our hospital. She underwent esophagogastroduodenoscopy, which revealed abnormally strong contractions in the distal esophagus. Esophageal biopsy specimens showed massive eosinophil infiltration into the epithelium, and high-resolution manometry (HRM) also demonstrated abnormally strong contractions in the distal esophagus. Based on these results, she was diagnosed with Jackhammer esophagus (JHE) due to eosinophilic esophagitis (EoE). Treatment was started with 5 mg/day of prednisolone (PSL), and the number of peripheral blood eosinophils quickly decreased without any improvement in the patient's dysphagia. Esophageal biopsy specimens obtained after the PSL treatment showed the disappearance of eosinophils from the epithelium. However, abnormally strong contractions were still detected on HRM. Per-oral endoscopic myotomy (POEM) was performed to treat the JHE. Interestingly, the intraoperative esophageal muscle biopsy sample demonstrated massive eosinophil infiltration into the muscle layer. After the POEM, the patient's symptoms improved, and abnormal contractions were no longer detected on HRM. The current case suggests that when EoE combined with an esophageal motility disorder are refractory to steroid therapy, clinicians should be aware that motility disorders can develop due to eosinophil infiltration deep into the esophageal muscularis propria.

  Oct. 2018, Clinical journal of gastroenterology, 11(5) (5), 377 - 381, English, Domestic magazine

  [Refereed]

  Scientific journal


• A comparison of the clinical outcomes of esophagectomy and chemoradiotherapy after noncurative endoscopic submucosal dissection for esophageal squamous cell carcinoma.

  Yasufumi Koterazawa, Tetsu Nakamura, Taro Oshikiri, Shingo Kanaji, Shinwa Tanaka, Tsukasa Ishida, Kimihiro Yamashita, Takeru Matsuda, Yoshinori Morita, Satoshi Suzuki, Yoshihiro Kakeji

  PURPOSE: Endoscopic submucosal dissection (ESD) is widely used to treat esophageal cancer, but some patients require additional treatment due to the possibility of lymph node metastasis. The aim of this study was to elucidate the clinical outcomes of these additional treatments. METHODS: The study included 59 patients who developed superficial esophageal squamous cell carcinoma after noncurative ESD treated between 2005 and 2016, of whom 28 underwent esophagectomy and 31 received chemoradiotherapy (CRT). RESULTS: The median follow-up periods were 45 months in the esophagectomy group and 41 months in the CRT group. The overall survival did not differ significantly between the groups (P = 0.46). However, there were no recurrences in the esophagectomy group, and the disease-specific survival rate was significantly higher in this group (P = 0.042). Among the patients at high risk for recurrence due to massive tumor invasion (≥ SM2) with lymphovascular invasion (esophagectomy group, six patients; CRT group, ten patients), none in the esophagectomy group had recurrence, whereas four in the CRT group died of esophageal cancer (P = 0.031). CONCLUSION: The overall survival did not differ significantly between the groups. However, compared with CRT, esophagectomy provided more favorable disease control for patients with massive tumor invasion (≥ SM2) with lymphovascular invasion.

  Aug. 2018, Surgery today, 48(8) (8), 783 - 789, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Clinical outcomes of endoscopic submucosal dissection for superficial esophageal neoplasms extending to the cervical esophagus.

  Ryusuke Ariyoshi, Takashi Toyonaga, Shinwa Tanaka, Hirofumi Abe, Yoshiko Ohara, Fumiaki Kawara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma

  BACKGROUND: The feasibility and safety of endoscopic submucosal dissection (ESD) for superficial esophageal neoplasms extending to the cervical esophagus currently remain unknown because of the limited number of cases. We aimed to clarify the clinical outcomes of these cases. METHODS: This was a case series study conducted at a single institution that enrolled 26 consecutive patients with superficial esophageal neoplasms extending to the cervical esophagus who underwent ESD between July 2003 and December 2015. RESULTS: En bloc and complete resection rates were both 100 % and no major intraprocedural complications occurred. Thirteen patients were treated with prophylactic steroid therapy. The incidence of postoperative stricture in patients with a circumferential mucosal defect of more than three-quarters was 72.7 %. Four patients required entire circumferential resection, with perforation occurring after endoscopic balloon dilation (EBD) in two and EBD being required for more than 1 year in the other two. CONCLUSIONS: ESD including the cervical esophagus is technically feasible. Circumferential resection may cause refractory postoperative stricture or post-EBD perforation, so needs to be avoided where possible.

  Jun. 2018, Endoscopy, 50(6) (6), 613 - 617, English, International magazine

  [Refereed]

  Scientific journal


• Clinical outcomes of deep invasive submucosal colorectal cancer after ESD.

  Daisuke Watanabe, Takashi Toyonaga, Makoto Ooi, Tetsuya Yoshizaki, Yoshiko Ohara, Shinwa Tanaka, Fumiaki Kawara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki, Takeru Matsuda, Yasuo Sumi, Mari Nishio, Hiroshi Yokozaki, Takeshi Azuma

  BACKGROUND AND STUDY AIMS: Endoscopic submucosal dissection (ESD) is a reliable method that can replace surgery under certain conditions. However, limited information is available on the clinical course of T1b colorectal cancer (CRC) after ESD. The aim of the study was to clarify the feasibility of ESD for T1b CRC. PATIENTS AND METHODS: Three hundred and two patients with 312 T1 CRC were identified in this retrospective cohort study. All patients were treated with ESD, other endoscopic treatments, or surgery. In this study, we (I) investigated the en bloc resection rate of ESD and (II) compared the overall survival (OS) rate for patients who underwent ESD with additional surgery (Group A) and surgery without upfront endoscopic resection (Group B) for T1b CRC. RESULTS: No significant differences were observed in the en bloc resection rates between T1b and T1a CRC (100 vs. 98.7%), but the en bloc R0 resection rate was significantly lower in T1b CRC than in T1a CRC (64.7 vs. 97.4%). Regarding complications, perforations occurred in 2.9% of patients with T1b CRC, which was not significantly different from the rate of 5.3% in patients with T1a CRC. No significant differences were observed in the OS or recurrence-free survival (RFS) curves between Groups A and B (OS rates at 5 years: 92.3 vs. 88.9%, RFS rates at 5 years: 81.4 vs. 85.3%). Similarly, the 5-year disease-specific survival (DSS) rate of Group A was identical to that of Group B (both 100%). CONCLUSIONS: ESD for T1b CRC before surgery is a possible strategy because of the low rate of complications and favorable long-term outcomes.

  Apr. 2018, Surgical endoscopy, 32(4) (4), 2123 - 2130, English, International magazine

  [Refereed]

  Scientific journal


• 早期胃癌研究会症例 胃原発濾胞性リンパ腫の1例

  阿部洋文, 梅垣英次, Yokozaki Hiroshi, 拝原正直, 藤尾誓, 迫智也, 賀来英俊, 阪口博哉, 有吉隆佑, 小原佳子, 河原史明, 田中心和, 石田司, Morita Yoshinori, 豊永高史

  (株)医学書院, Mar. 2018, 胃と腸, 53(3) (3), 353 - 360, Japanese


• Two penetrating vessels as a novel indicator of the appropriate distal end of peroral endoscopic myotomy.

  Shinwa Tanaka, Fumiaki Kawara, Takashi Toyonaga, Haruhiro Inoue, Robert Bechara, Namiko Hoshi, Hirohumi Abe, Yoshiko Ohara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki

  BACKGROUND AND AIM: One of the challenges during peroral endoscopic myotomy (POEM) is ensuring the appropriate length of myotomy on the gastric side. To determine the appropriate distal end of the gastric myotomy, we focused on the two penetrating vessels (TPVs) found in the gastric cardia during POEM. In the present study, we evaluated whether the TPVs could serve as an accurate indicator of the appropriate distal end of the gastric myotomy. METHODS: All patients who underwent POEM between March and August 2016 were included for this study. When making the submucosal tunnel in the 5 o'clock direction into the stomach, two vessels penetrating through the circular muscle along the edge of oblique muscle in the cardia can be exposed. We designated these two vessels as TPVs. The myotomy was extended until the second TPVs was exposed. The anal end of the submucosal tunnel was confirmed by the double-scope POEM technique, and the length from the gastroesophageal junction to the anal side end of the myotomy was measured by the scale on the endoscope. RESULTS: Among 37 patients who underwent myotomy in the 5 o'clock position, TPVs were found in 34 patients (91.2%). Sufficient submucosal tunneling on the gastric side was confirmed by the double-scope POEM technique in these 34 patients. Median length of the gastric myotomy was 3.0 cm (range 2-4 cm). CONCLUSION: TPVs appears to be a simple and reliable indicator to determine the appropriate distal end of myotomy.

  Mar. 2018, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 30(2) (2), 206 - 211, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• New Development for Safer Endoscopic Submucosal Dissection using Carbon Dioxide (CO₂) Laser

  Yoshinori Morita, Ryusuke Ariyoshi, Norihiro Honda, Hisanao Hazama, Kunio Awazu

  Japan Society for Laser Surgery and Medicine, 2018, Nippon Laser Igakkaishi, 38(4) (4), 413 - 420

  Scientific journal


• 消化器科領域の炭酸ガスレーザー より安全な内視鏡的粘膜下層剥離術を目指した、炭酸ガスレーザーを用いた新たな展開

  Morita Yoshinori, 有吉隆佑, 本多典広, 間久直, 粟津邦男

  (NPO)日本レーザー医学会, Jan. 2018, 日本レーザー医学会誌, 38(4) (4), 413 - 419, Japanese


• Line-assisted endoscopic complete closure of a large perforation during colonic endoscopic submucosal dissection.

  Hiroko Nakahira, Yoji Takeuchi, Jose Santiago Garcia, Yoshinori Morita, Noriya Uedo, Ryu Ishihara, Alberto Herreros de Tejada

  Jan. 2018, Endoscopy, 50(1) (1), E32-E33 - E33, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• A novel method of endoscopic-assisted esophageal clearance in advanced achalasia.

  Shinwa Tanaka, Fumiaki Kawara, Takashi Toyonaga, Robert Bechara, Namiko Hoshi, Hirofumi Abe, Yoshiko Ohara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki

  Background and study aims : In order to perform peroral endoscopic myotomy (POEM) safely, retained liquid and food debris must be removed before the procedure is started. We developed a novel technique using a super-slim gastroscope, and a gastric tube to remove retained food debris in achalasia patients. In this study, the safety and efficacy of this novel technique were investigated. Patients and methods : Eleven patients with achalasia were enrolled in this study and underwent this novel method for esophageal clearance. Results:  All patients had complete clearance of the retained food debris using this method. The median procedure time (range) was 13 (6 - 30) minutes. There were no serious adverse events (AEs) and one minor AE of mucosal erythema due to mucosal suctioning. Conclusion:  This novel method for esophageal clearance is safe and effective in achalasia patients with large amounts of retained food debris.

  Jan. 2018, Endoscopy international open, 6(1) (1), E86-E89 - E89, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Enormous postoperative perforation after endoscopic submucosal dissection for duodenal cancer successfully treated with filling and shielding by polyglycolic acid sheets with fibrin glue and computed tomography-guided abscess puncture.

  Yoshiko Ohara, Kengo Takimoto, Takashi Toyonaga, Tomohiro Yamaguchi, Hiroya Sakaguchi, Fumiaki Kawara, Shinwa Tanaka, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki

  A female in her 70s underwent esophagogastroduodenoscopy (EGD) for screening, and a 0-IIa lesion measuring approximately 15 mm was detected in the descending portion of the duodenum. Due to the malignant potency of the lesion, endoscopic submucosal dissection (ESD) was performed. Microperforation occurred during ESD. The lesion was removed en bloc and the post-ESD ulcer bed was closed with clips. The next day, the patient had abdominal pain and computed tomography (CT) revealed a small amount of free air in the retroperitoneal space. Since there were no findings to suggest panperitonitis, conservative medical management including fasting and antibiotics was continued. Abdominal pain subsequently improved. However, EGD on the 8th day after ESD for follow-up showed shedding of the post-ESD ulcer that penetrated the retroperitoneal space. A surgical approach was not indicated because a few days may have already passed since postoperative perforation occurred and the spread of inflammation to the retroperitoneum was suspected. In an attempt to promote closure of the perforated cavity, we patched polyglycolic acid sheets and fibrin glue to the cavity wall on days 17, 18, and 20 after ESD. The formation of granulation tissue was detected in the cavity one week later. CT showed an abscess in the right retroperitoneum, for which CT-guided abscess puncture was performed. Thereafter, the cavity gradually decreased. After the initiation of oral intake on postoperative day (POD) 63, the general condition of the patient was stable and she was discharged on POD 87. Polyglycolic acid sheets with fibrin glue and CT-guided abscess puncture were useful for closing the large cavity that developed after duodenal postoperative perforation.

  Dec. 2017, Clinical journal of gastroenterology, 10(6) (6), 524 - 529, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Safe management of laparoscopic endoscopic cooperative surgery for superficial non-ampullary duodenal epithelial tumors.

  Yasunori Otowa, Shingo Kanaji, Yoshinori Morita, Satoshi Suzuki, Masashi Yamamoto, Yoshiko Matsuda, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Fumiaki Kawara, Shinwa Tanaka, Tsukasa Ishida, Takashi Toyonaga, Takeshi Azuma, Yoshihiro Kakeji

  Background and study aims  Endoscopic submucosal dissection (ESD) for duodenal tumors results in a high delayed perforation rate due to the thinness of the duodenal wall. In most cases with perforation after duodenal ESD, additional surgery is needed due to severe peritonitis. A newly developed procedure, laparoscopic endoscopic cooperative surgery for duodenal tumors (D-LECS), may help to avoid perforation after ESD. In our institution, patients with superficial non-ampullary duodenal epithelial tumors (SNADET) smaller than 50 mm which could not have en-bloc resection by endoscopic mucosal resection were treated with D-LECS. After a laparoscopic exposure of anterior duodenal wall of second portion, ESD was performed. Laparoscopic suturing from the serosal side of ESD site was performed for reinforcement. There were neither postoperative leakage nor other complications. Therefore, D-LECS can be performed safely and prevent perforation after ESD for SNADET. D-LECS could be selected as a treatment for SNADET which can be cured by ESD.

  Nov. 2017, Endoscopy international open, 5(11) (11), E1153-E1158 - E1158, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 十二指腸腫瘍に対する腹腔鏡内視鏡合同手術の手術成績の検討

  永田 真知子, 金治 新悟, 森田 圭紀, 河原 史明, 音羽 泰則, 山本 将士, 松田 佳子, 押切 太郎, 中村 哲, 豊永 高史, 鈴木 知志, 東 健, 掛地 吉弘

  (一社)日本消化器外科学会, Oct. 2017, 日本消化器外科学会雑誌, 50(Suppl.2) (Suppl.2), 318 - 318, Japanese


• 炭酸ガスレーザーを用いた内視鏡的粘膜下層剥離術における大腸の粘膜層切開と粘膜下層剥離の安全性評価

  野口 拓真, 本田 典広, 間 久直, 粟津 邦男, 森田 圭紀

  (NPO)日本レーザー医学会, Oct. 2017, 日本レーザー医学会誌, 38(3) (3), 313 - 313, Japanese


• Evaluation of an e-learning system for diagnosis of gastric lesions using magnifying narrow-band imaging: a multicenter randomized controlled study.

  Hiroyoshi Nakanishi, Hisashi Doyama, Hideki Ishikawa, Noriya Uedo, Takuji Gotoda, Mototsugu Kato, Shigeaki Nagao, Yasuaki Nagami, Hiroyuki Aoyagi, Atsushi Imagawa, Junichi Kodaira, Shinya Mitsui, Nozomu Kobayashi, Manabu Muto, Hajime Takatori, Takashi Abe, Masahiko Tsujii, Jiro Watari, Shuhei Ishiyama, Ichiro Oda, Hiroyuki Ono, Kazuhiro Kaneko, Chizu Yokoi, Tetsuya Ueo, Kunihisa Uchita, Kenshi Matsumoto, Takashi Kanesaka, Yoshinori Morita, Shinichi Katsuki, Jun Nishikawa, Katsuhisa Inamura, Tetsu Kinjo, Katsumi Yamamoto, Daisuke Yoshimura, Hiroshi Araki, Hiroshi Kashida, Ayumu Hosokawa, Hirohito Mori, Haruhiro Yamashita, Osamu Motohashi, Kazuhiko Kobayashi, Michiaki Hirayama, Hiroyuki Kobayashi, Masaki Endo, Hiroo Yamano, Kazunari Murakami, Tomoyuki Koike, Kingo Hirasawa, Youichi Miyaoka, Hidetaka Hamamoto, Takuto Hikichi, Norihiro Hanabata, Ryo Shimoda, Shinichiro Hori, Tadashi Sato, Shinya Kodashima, Hiroyuki Okada, Tomohiko Mannami, Shojiro Yamamoto, Yasumasa Niwa, Kazuo Yashima, Satoshi Tanabe, Hiro Satoh, Fumisato Sasaki, Tetsuro Yamazato, Yoshiou Ikeda, Hogara Nishisaki, Masahiro Nakagawa, Akio Matsuda, Fumio Tamura, Hitoshi Nishiyama, Keiko Arita, Keisuke Kawasaki, Kazushige Hoppo, Masashi Oka, Shinichi Ishihara, Michita Mukasa, Hiroaki Minamino, Kenshi Yao

  Oct. 2017, Endoscopy, 49(10) (10), 957 - 967, English, International magazine

  [Refereed]

  Scientific journal


• Efficacy of forced coagulation with low high-frequency power setting during endoscopic submucosal dissection.

  Tsukasa Ishida, Takashi Toyonaga, Yoshiko Ohara, Tadao Nakashige, Yasuaki Kitamura, Ryusuke Ariyoshi, Hiroshi Takihara, Shinichi Baba, Tetsuya Yoshizaki, Fumiaki Kawara, Shinwa Tanaka, Yoshinori Morita, Eiji Umegaki, Namiko Hoshi, Takeshi Azuma

  Aug. 2017, World journal of gastroenterology, 23(29) (29), 5422 - 5430, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Peroral endoscopic myotomy using FlushKnife BT: a single-center series.

  Shinwa Tanaka, Takashi Toyonaga, Fumiaki Kawara, Ian S Grimm, Namiko Hoshi, Hirofumi Abe, Yoshiko Ohara, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma

  BACKGROUND AND STUDY AIMS : Peroral endoscopic myotomy (POEM) is an evolving new treatment strategy for achalasia. Although several kinds of electrosurgical knives have been used in performing POEM, the best device has yet to be determined. The FlushKnife BT is a waterjet-emitting short needle-knife with a small ball tip (BT) that offers the potential to perform all aspects of POEM with a single device. In this study, we evaluated the safety and efficiency of the FlushKnife BT for POEM. PATIENTS AND METHODS:  A total of 54 consecutive patients with achalasia and other spastic esophageal motility disorders, such as jackhammer esophagus or distal esophageal spasm, who underwent POEM between January 2016 and August 2016, were included in this retrospective study. RESULTS:  The median operation time was 73.0 minutes (range 39 - 184 minutes). All procedures were completed using only the FlushKnife BT without changing to any other electrosurgical instrument. The median number of additional submucosal injections with an injection needle was 0 (range 0 - 1). Endoscopic vessel sealing was performed a mean of 3 times (range 0 - 7). The median number of bleeding episodes requiring treatment with hemostatic forceps was 0 (range 0 - 5). There were no significant adverse events. Seven of 52 patients (13.5 %) reported symptoms of gastroesophageal reflux disease such as heartburn or acid reflux at 3 month follow-up. CONCLUSIONS:  The FlushKnife BT enabled POEM to be performed with very few device exchanges, either for re-injection or to control intraoperative bleeding. In this uncontrolled case series, the ability of the FlushKnife BT to perform nearly all aspects of the POEM procedure seems to make it particularly well suited to this procedure.

  Jul. 2017, Endoscopy international open, 5(7) (7), E663-E669 - E669, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Gastric plexiform fibromyxoma resected by endoscopic submucosal dissection after observation of chronological changes: A case report.

  Fumiaki Kawara, Shinwa Tanaka, Takashi Yamasaki, Yoshinori Morita, Yoshiko Ohara, Yoshihiro Okabe, Namiko Hoshi, Takashi Toyonaga, Eiji Umegaki, Hiroshi Yokozaki, Takanori Hirose, Takeshi Azuma

  Jun. 2017, World journal of gastrointestinal oncology, 9(6) (6), 263 - 267, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Efficacy of a new hemostatic forceps during gastric endoscopic submucosal dissection: A prospective randomized controlled trial.

  Shinwa Tanaka, Takashi Toyonaga, Yoshinori Morita, Tsukasa Ishida, Namiko Hoshi, Kevin L Grimes, Yoshiko Ohara, Tetsuya Yoshizaki, Fumiaki Kawara, Eiji Umegaki, Takeshi Azuma

  BACKGROUND AND AIM: Currently, endoscopic submucosal dissection (ESD) is a widely accepted standard treatment for early gastric cancer, but one challenging aspect of ESD is hemostasis. We developed a new hemostatic forceps (FD-Y0007) with the aim of achieving more effective hemostasis and investigated the hemostatic ability of the FD-Y0007 during gastric ESD in humans. METHODS: This study was a prospective randomized controlled trial, which was conducted at a cancer referral center. Sixty-six patients who were scheduled to undergo ESD were enrolled and randomly assigned to either the Coagrasper or the FD-Y0007, which was used for hemostasis throughout the case. The primary end point was the time required to obtain hemostasis, which was measured for the first episode of bleeding during each case. RESULTS: Hemostasis time for the first bleeding episode during ESD was 73.0 s for the Coagrasper and 21.5 s for the FD-Y0007 (P < 0.001). When all episodes of bleeding were included, hemostasis time was 56.8 s in the Coagrasper group and 25.5 s in FD-Y0007group (P < 0.0001). The frequency of adverse events (perforation: 3.4% vs 7.1%; delayed bleeding: 0% vs 0%) was not significantly different between the two groups. CONCLUSIONS: Compared with the Coagrasper, the FD-Y0007 efficiently reduces the hemostatic time during gastric ESD with no increase in adverse events.

  Apr. 2017, Journal of gastroenterology and hepatology, 32(4) (4), 846 - 851, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Factors associated with residual gastroesophageal reflux disease symptoms in patients receiving proton pump inhibitor maintenance therapy.

  Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsushi Uda, Atsuhiro Masuda, Masaya Saito, Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Kazuhiko Yamashita, Takeshi Hirano, Midori Hirai, Takeshi Azuma

  AIM: To elucidate the factors associated with residual gastroesophageal reflux disease (GERD) symptoms in patients receiving proton pump inhibitor (PPI) maintenance therapy in clinical practice. METHODS: The study included 39 GERD patients receiving maintenance PPI therapy. Residual symptoms were assessed using the Frequency Scale for Symptoms of GERD (FSSG) questionnaire and the Gastrointestinal Symptom Rating Scale (GSRS). The relationships between the FSSG score and patient background factors, including the CYP2C19 genotype, were analyzed. RESULTS: The FSSG scores ranged from 1 to 28 points (median score: 7.5 points), and 19 patients (48.7%) had a score of 8 points or more. The patients' GSRS scores were significantly correlated with their FSSG scores (correlation coefficient = 0.47, P < 0.005). In erosive esophagitis patients, the FSSG scores of the CYP2C19 rapid metabolizers (RMs) were significantly higher than the scores of the poor metabolizers and intermediate metabolizers (total scores: 16.7 ± 8.6 vs 7.8 ± 5.4, P < 0.05; acid reflux-related symptom scores: 12 ± 1.9 vs 2.5 ± 0.8, P < 0.005). In contrast, the FSSG scores of the CYP2C19 RMs in the non-erosive reflux disease patients were significantly lower than those of the other patients (total scores: 5.5 ± 1.0 vs 11.8 ± 6.3, P < 0.05; dysmotility symptom-related scores: 1.0 ± 0.4 vs 6.0 ± 0.8, P < 0.01). CONCLUSION: Approximately half of the GERD patients receiving maintenance PPI therapy had residual symptoms associated with a lower quality of life, and the CYP2C19 genotype appeared to be associated with these residual symptoms.

  Mar. 2017, World journal of gastroenterology, 23(11) (11), 2060 - 2067, English, International magazine

  [Refereed]

  Scientific journal


• Usefulness of a novel slim type FlushKnife-BT over conventional FlushKnife-BT in esophageal endoscopic submucosal dissection.

  Yoshiko Ohara, Takashi Toyonaga, Namiko Hoshi, Shinwa Tanaka, Shinichi Baba, Hiroshi Takihara, Fumiaki Kawara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma

  Mar. 2017, World journal of gastroenterology, 23(9) (9), 1657 - 1665, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Usefulness of a novel slim type FlushKnife-BT over conventional FlushKnife-BT in esophageal endoscopic submucosal dissection

  Yoshiko Ohara, Takashi Toyonaga, Namiko Hoshi, Shinwa Tanaka, Shinichi Baba, Hiroshi Takihara, Fumiaki Kawara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma

  Mar. 2017, WORLD JOURNAL OF GASTROENTEROLOGY, 23(9) (9), 1657 - 1665, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Current status of colorectal ESD and challenge to the limit.

  Takashi Toyonaga, Yoshinori Morita, Eiji Umegaki

  2017, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 114(6) (6), 989 - 1000, Japanese, Domestic magazine

  [Refereed]

  Scientific journal


• Endoscopic submucosal dissection of cecal lesions in proximity to the appendiceal orifice.

  Harold Jacob, Takashi Toyonaga, Yoshiko Ohara, Eiji Tsubouchi, Hiroshi Takihara, Shinichi Baba, Tetsuya Yoshizaki, Fumiaki Kawara, Shinwa Tanaka, Tsukasa Ishida, Namiko Hoshi, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma

  Sep. 2016, Endoscopy, 48(9) (9), 829 - 36, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Feasibility and safety of endoscopic submucosal dissection for lower rectal tumors with hemorrhoids.

  Shinwa Tanaka, Takashi Toyonaga, Yoshinori Morita, Namiko Hoshi, Tsukasa Ishida, Yoshiko Ohara, Tetsuya Yoshizaki, Fumiaki Kawara, Eiji Umegaki, Takeshi Azuma

  Jul. 2016, World journal of gastroenterology, 22(27) (27), 6268 - 75, English, International magazine

  [Refereed]

  Scientific journal


• Feasibility and safety of endoscopic submucosal dissection for lesions involving the ileocecal valve.

  Tetsuya Yoshizaki, Takashi Toyonaga, Shinwa Tanaka, Yoshiko Ohara, Fumiaki Kawara, Shinichi Baba, Eiji Tsubouchi, Hiroshi Takihara, Daisuke Watanabe, Tsukasa Ishida, Namiko Hoshi, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma

  BACKGROUND AND STUDY AIM: Endoscopic submucosal dissection (ESD) has been applied to treat early colorectal cancers. The aim of this study was to clarify the clinical course of ESD for lesions involving the ileocecal valve (ICV) by evaluating the successful resection rates, and the risk and frequency of adverse events. PATIENTS AND METHODS: The outcome of ESD on 38 ICV lesions was compared with the outcome of 132 cecal lesions that did not involve the ICV or appendiceal orifice during the same study period. The factors related to longer procedure time, postoperative stricture development, and tumor recurrence were investigated for ESD of ICV lesions. RESULTS: There was no significant difference between the ICV and non-ICV groups in the en block resection rates. The median procedure time was significantly longer in the ICV group than in the non-ICV group, with a point estimate of the difference of 37 minutes (95 % confidence interval [CI] 20.00 to 56.00; P  < 0.01). None of the patients developed symptomatic post-ESD stricture or tumor recurrence. ESD procedure duration was ≥ 120 minutes in 16 lesions and < 120 minutes in 22 lesions of the ICV group. A specimen diameter of ≥ 40 mm and tumor extension into terminal ileum were factors related to a longer procedure time (odds ratio [OR] 8.40, 95 %CI 1.53 to 46.10, P = 0.01; OR 10.60, 95 %CI 2.17 to 51.40, P  < 0.01, respectively). CONCLUSIONS: ICV lesions can be resected by ESD without major adverse events or causing symptomatic stricture development. However, ESD for ICV lesions should be performed only by expert endoscopists, as the procedure requires accomplished endoscopic skill and experience.

  Jul. 2016, Endoscopy, 48(7) (7), 639 - 45, English, International magazine

  [Refereed]

  Scientific journal


• 【消化器治療・最前線】 CO2レーザーの大腸ESDへの応用

  Morita Yoshinori, 東健

  (株)オプトロニクス社, Jul. 2016, Medical Photonics, (22) (22), 29 - 34, Japanese


• Optimization of steroid injection intervals for prevention of stricture after esophageal endoscopic submucosal dissection: A randomized controlled trial

  Chika Wakahara, Yoshinori Morita, Shinwa Tanaka, Namiko Hoshi, Fumiaki Kawara, Megumi Kibi, Tsukasa Ishida, Mariko Man-, Tsuyoshi Fujita, Takashi Toyonaga

  Jul. 2016, ACTA GASTRO-ENTEROLOGICA BELGICA, 79(3) (3), 315 - 320, English

  [Refereed]

  Scientific journal


• Current status of transnasal endoscopy worldwide using ultrathin videoscope for upper gastrointestinal tract.

  Tokuma Tanuma, Yoshinori Morita, Hisashi Doyama

  Transnasal endoscopy with an ultrathin endoscope has been reported to be highly acceptable even without any sedative measures. Poor image quality and complex manipulation have been reported as shortcomings of this type of endoscopy compared with standard transoral endoscopy. However, image quality has improved markedly with the latest ultrathin endoscopes. To investigate the status of clinical use of endoscopes, we recently conducted a questionnaire survey involving 149 facilities (98 in Japan and 51 overseas). In Japan, transnasal endoscopes were being used primarily in clinics (34% in clinics and 9% in hospitals). Overseas, however, transnasal endoscopes were seldom used (1% in hospitals and 0% in clinics). This may be attributable to the complex pretreatment and more challenging manipulation required for transnasal endoscopes. However, it is evident that transnasal endoscopes are highly acceptable for patients. If the pretreatment required is simplified and healthcare physicians improve their skills and understanding, this type of endoscopy will have high potential for common use.

  Apr. 2016, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 28 Suppl 1, 25 - 31, English, International magazine

  [Refereed]

  Scientific journal


• Differences in routine esophagogastroduodenoscopy between Japanese and international facilities: A questionnaire survey.

  Noriya Uedo, Takuji Gotoda, Shigetaka Yoshinaga, Tokuma Tanuma, Yoshinori Morita, Hisashi Doyama, Akira Aso, Toshiaki Hirasawa, Tomonori Yano, Norihisa Uchita, Shiaw-Hooi Ho, Ping-Hsin Hsieh

  BACKGROUND AND AIM: The mortality rate of gastric cancer (GC) is close to the incidence rate worldwide. However, in Korea and Japan, the mortality rate of GC is less than half of the incidence rate. We hypothesized that good-quality routine esophagogastroduodenoscopy (EGD) contributes to a high detection rate for early GC (EGC) and improves mortality in these countries. METHODS: To clarify the differences in routine EGD, a questionnaire survey was conducted in 98 Japanese and 53 international institutions. RESULTS: Prevalence of screening examination among routine EGD was higher in Japanese than in international institutions. Japanese endoscopists noted that endoscopic mucosal atrophy was the most significant risk factor for GC, whereas international endoscopists paid more attention to clinical information such as age, symptoms and family history. Antispasmodics, mucolytics and defoaming agents were used more frequently in Japanese institutions. The examination time was similar (mostly 5-10 min) between Japanese and international institutions. Japanese endoscopists took more pictures (>20 in almost all institutions) than international endoscopists (≤20 in two-thirds of institutions). In Japanese institutions, biopsy specimens were more frequently taken from areas of mucosal discoloration, unevenness or spontaneous bleeding rather than from obvious endoscopic lesions such as ulceration or polyps. In most Japanese institutions, one or two biopsy specimens were taken per lesion, compared with ≥three in international institutions. CONCLUSION: There were some discrepancies between Japanese and international institutions for routine EGD. Thus, standardization is required for adequate risk assessment, proper techniques, and knowledge of endoscopic diagnosis of EGC.

  Apr. 2016, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 28 Suppl 1, 16 - 24, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Basic principles and practice of gastric cancer screening using high-definition white-light gastroscopy: Eyes can only see what the brain knows.

  Takuji Gotoda, Noriya Uedo, Shigetaka Yoshinaga, Tokuma Tanuma, Yoshinori Morita, Hisashi Doyama, Akira Aso, Toshiaki Hirasawa, Tomonori Yano, Kunihisa Uchita, Shiaw-Hooi Ho, Ping-Hsin Hsieh

  Apr. 2016, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 28 Suppl 1, 2 - 15, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Optimization of steroid injection intervals for prevention of stricture after esophageal endoscopic submucosal dissection: A randomized controlled trial

  Chika Wakahara, Yoshinori Morita, Shinwa Tanaka, Namiko Hoshi, Fumiaki Kawara, Megumi Kibi, Tsukasa Ishida, Mariko Man-I, Tsuyoshi Fujita, Takashi Toyonaga

  Universa Press, 2016, Acta Gastro-Enterologica Belgica, 79(3) (3), 315 - 320, English

  Scientific journal


• Risk of stricture after endoscopic submucosal dissection for large rectal neoplasms.

  Yoshiko Ohara, Takashi Toyonaga, Shinwa Tanaka, Tsukasa Ishida, Namiko Hoshi, Tetsuya Yoshizaki, Fumiaki Kawara, Ka Luen Lui, Kanokkan Tepmalai, Alisara Damrongmanee, Mitsuru Nagata, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma

  Jan. 2016, Endoscopy, 48(1) (1), 62 - 70, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Electrolyte depletion syndrome (McKittrick-Wheelock syndrome) successfully treated by endoscopic submucosal dissection.

  Yoshiko Ohara, Takashi Toyonaga, Daisuke Watanabe, Namiko Hoshi, Soichiro Adachi, Tetsuya Yoshizaki, Fumiaki Kawara, Shinwa Tanaka, Tsukasa Ishida, Tatsuya Okuno, Nobunao Ikehara, Yoshinori Morita, Eiji Umegaki, Hiroshi Yokozaki, Takeshi Azuma

  A 66-year-old woman presented to us with malaise, anorexia and rectal mucous discharge, and her laboratory data showed severe hyponatremia, hypokalemia, hypochloremia and renal failure. Computed tomography revealed massive occupation of the rectum by a large tumor. Colonoscopy revealed a mucus-rich villous tumor in the rectum. As there were no other factors that could cause an electrolyte disorder, she was diagnosed with McKittrick-Wheelock syndrome (MWS). The current standard treatment for MWS is partial surgical colectomy. However, surgeries are invasive and postoperative complications sometimes become an issue. After confirming no signs of submucosal invasion of the tumor by magnifying chromoendoscopic examination, endoscopic submucosal dissection (ESD) was indicated. The tumor was completely removed en bloc without adverse events. The histology showed a mucosal adenocarcinoma containing a villous component, 24.5 x 17.0 cm in size. This removal dramatically improved the patient's symptoms and the electrolyte abnormalities without medication. Although several sessions of endoscopic balloon dilation were required to treat postoperative stricture, she has been symptom-free and had no recurrence for 4 years after treatment. We experienced a case of MWS treated by ESD instead of surgery. ESD should be feasible and beneficial for the treatment of MWS.

  Oct. 2015, Clinical journal of gastroenterology, 8(5) (5), 280 - 4, English, Domestic magazine

  [Refereed]

  Scientific journal


• 【消化器癌におけるレーザー光を用いた診断・治療】炭酸ガスレーザーによる内視鏡的粘膜下層剥離術

  石井 克典, 間 久直, 小畑 大輔, 森田 圭紀, 東 健, 粟津 邦男

  (株)先端医学社, Aug. 2015, G.I.Research, 23(4) (4), 282 - 287, Japanese


• Efficacy and safety of 1-week Helicobacter pylori eradication therapy and 7-week rebamipide treatment after endoscopic submucosal dissection of early gastric cancer in comparison with 8-week PPI standard treatment: a randomized, controlled, prospective, multicenter study.

  Kazuhide Higuchi, Toshihisa Takeuchi, Noriya Uedo, Yoji Takeuchi, Yuji Naito, Nobuaki Yagi, Kazunari Tominaga, Hirohisa Machida, Takashi Tamada, Yoshinori Morita, Shujiro Yazumi, Junichi Yamao, Mikitaka Iguchi, Takeshi Azuma

  BACKGROUND: Endoscopic submucosal dissection (ESD) has been developed for early gastric cancer (EGC). Helicobacter pylori eradication therapy has been reported to have a preventive effect against metachronous recurrence of EGC after ESD. However, the efficacy and safety of eradication therapy on ESD-induced ulcer healing are not clear. In a randomized control study, we compared the standard therapy (8-week proton pump inhibitor) and eradication therapy combined with subsequent treatment with 7-week rebamipide for healing ESD-induced ulcers. METHODS: A multicenter, randomized, open-label study was conducted. In group A, patients received 20 mg of omeprazole for 56 days. In group B, patients received 40 mg of omeprazole, 1,500 mg of amoxicillin, and 800 mg of clarithromycin for 7 days, and then 300 mg of rebamipide for 49 days. The primary end point was to evaluate the scarring ratio. RESULTS: The scarring rate in group A was significantly higher than that in group B [85.0 % (34/40) vs. 56.8 % (21/37), P = 0.011]. The scarring rate of ulcers with an area ≥565.5 mm(2) in group A was significantly higher than that in group B [78.9 % (15/19) vs. 37.5 % (6/16), P = 0.018]. There was no significant difference between the groups in the scarring rate of smaller ulcers. No serious adverse events were observed in any of the patients in either group. CONCLUSION: H. pylori eradication therapy and 7-week rebamipide monotherapy were not superior to PPI monotherapy, but this combination therapy for smaller sized ulcers was an optimal therapeutic option for healing. Serious adverse events were not observed in either group.

  Jul. 2015, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 18(3) (3), 612 - 7, English, Domestic magazine

  [Refereed]

  Scientific journal


• Feasibility and safety of endoscopic submucosal dissection for large colorectal tumors.

  Shinwa Tanaka, Takashi Toyonaga, Yoshinori Morita, Namiko Hoshi, Tsukasa Ishida, Yoshiko Ohara, Tetsuya Yoshizaki, Fumiaki Kawara, Takeshi Azuma

  PURPOSE: Recently, endoscopic submucosal dissection (ESD) has been applied for superficial colorectal neoplasms and the number of publications about it has been increasing, but little is known about the outcomes of colorectal ESD for the lesions > 50 mm. In this study, we evaluated the feasibility and safety of colorectal ESD for the lesions > 50 mm compared with the lesions < 50 mm. METHODS: A total of 674 superficial colorectal neoplasms in 629 patients treated by ESD at Kobe University Hospital from July 2008 to July 2013 were included in the analysis. RESULTS: The median operation time (range) in the large lesion group (≥ 5 cm) was 109 (37 to 596) minutes, and it was 55 (6 to 248) minutes in the small lesion group (< 5 cm). Median procedure speed (range) in the large lesion group was 0.28 (0.06 to 0.83) cm2/min, and it was 0.19 (0.04 to 0.83) cm2/min in the small lesion group. The en bloc resection rate and the curative resection rate in the small lesion group was 98.7% and 96.0%, and those were 95.7% and 91.4% in the large lesion group, respectively. In terms of adverse events, perforation, muscle damage, and postoperative bleeding occurred at similar frequency in both groups. CONCLUSIONS: ESD on colorectal lesions > 50 mm takes longer operation time; however, it is resected time effectively without increasing the risk of adverse events compared with smaller lesions by ESD.

  Jun. 2015, Surgical laparoscopy, endoscopy & percutaneous techniques, 25(3) (3), 223 - 8, English, International magazine

  [Refereed]

  Scientific journal


• Visualization of porcine gastric ulcer in vivo using intracavitary RF probe and its navigation system

  Matsuoka Yuichiro, Morita Yoshinori, Hashioka Yoshiki, Kumamoto Etsuko, Kutsumi Hiromu, Azuma Takeshi, Kuroda Kagayaki

  Jun. 2015, Proceedings of International Society for Magnetic Resonance in Medicine 23 th Annual Meeting and Exibition, 870, English

  [Refereed]

  International conference proceedings


• Clinical significance of the muscle-retracting sign during colorectal endoscopic submucosal dissection.

  Takashi Toyonaga, Shinwa Tanaka, Mariko Man-I, James East, Wataru Ono, Eisei Nishino, Tsukasa Ishida, Namiko Hoshi, Yoshinori Morita, Takeshi Azuma

  BACKGROUND AND STUDY AIMS: During colorectal endoscopic submucosal dissection (ESD), the feature of a muscle layer being pulled toward a neoplastic tumor is sometimes detected. We call this feature the muscle-retracting sign (MR sign). The aim of this study was to evaluate whether the MR sign is associated with particular types of neoplastic lesions and whether it has any clinical significance for ESD sessions. PATIENTS AND METHODS: A total of 329 patients underwent ESD for 357 colorectal neoplasms. The frequency of positivity for the MR sign was evaluated in different morphologic and histopathologic types of neoplasm. The success rate of complete resection and the incidence of complications were also evaluated according to whether lesions were positive or negative for the MR sign. RESULTS: The rates of positivity for the MR sign in the various lesion types were as follows: laterally spreading tumor - granular nodular mixed type (LST-G-M), 9.6 %; laterally spreading tumor - granular homogeneous type (LST-G-H) and laterally spreading tumor - nongranular type (LST-NG), 0 %; sessile type, 41.2 %. The resection rate was 100 % (329 /329) in lesions negative for the MR sign; however, it was 64.3 % (18 /28) in lesions positive for the MR sign, which was significantly lower (P < 0.001). CONCLUSIONS: The MR sign was present only in some protruding lesions, and more importantly, it was associated with a high risk of incomplete tumor removal by ESD. Our data indicate that lesions positive for the MR sign lesions should be dissected with great caution; alternatively, based on the features of the individual case, a switch to surgery should be considered for the benefit of the patient.

  Jun. 2015, Endoscopy international open, 3(3) (3), E246-51 - 51, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 画像診断との対比で学ぶ大腸疾患アトラス 絨毛腫瘍(Villous tumor)

  渡邉大輔, 吉崎哲也, 池原伸直, Morita Yoshinori, Toyonaga Takashi

  (株)メディカルレビュー社, May 2015, 大腸がんperspective, 2(2) (2), 92 - 95, Japanese


• Impact of formal training in endoscopic submucosal dissection for early gastrointestinal cancer: A systematic review and a meta-analysis.

  Miguel A Tanimoto, M Lourdes Guerrero, Yoshinori Morita, Jonathan Aguirre-Valadez, Elisa Gomez, Carlos Moctezuma-Velazquez, Jose A Estradas-Trujillo, Miguel A Valdovinos, Luis F Uscanga, Rikiya Fujita

  AIM: To summarize the clinical impact of a formal training for the effectiveness and safety of endoscopic submucosal dissection for gastrointestinal cancer. METHODS: We searched databases including PubMed, EMBASE and the Cochrane Library and Science citation Index updated to August 2014 to include eligible articles. In the Meta-analysis, the main outcome measurements were en bloc resection rate, local recurrence rate (R0) and the incidence of procedure-related complications (perforation, bleeding). RESULTS: En bloc resection was high for both, dissecting stomach tumors with an overall percentage of 93.2% (95%CI: 90.5-95.8) and dissecting colorectal tumors with an overall percentage of 89.4% (95%CI: 85.1-93.7). Although the number of studies reporting R0 resection (the dissected specimen was revealed free of tumor in both vertical and lateral margins) was small, the overall estimates for R0 resection were 81.4% (95%CI: 72-90.8) for stomach and 85.9% (95%CI: 77.5-95.5) for colorectal tumors, respectively. The analysis showed that the percentage of immediate perforation and bleeding were very low; 4.96 (95%CI: 3.6-6.3) and 1.4% (95%CI: 0.8-1.9) for colorectal tumors and 3.1% (95%CI: 2.0-4.1) and 4.8% (95%CI: 2.8-6.7) for stomach tumors, respectively. CONCLUSION: In order to obtain the same rate of success of the analyzed studies it is a necessity to create training centers in the western countries during the "several years" of gastroenterology residence first only to teach EGC diagnose and second only to train endoscopic submucosal dissection.

  Apr. 2015, World journal of gastrointestinal endoscopy, 7(4) (4), 417 - 28, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• ESD 手技の工夫 スワンブレードによるESD

  Morita Yoshinori

  (株)日本メディカルセンター, Apr. 2015, 臨床消化器内科, 30(5) (5), 618 - 622, Japanese


• Esophageal diverticulum exposed during endoscopic submucosal dissection of superficial cancer.

  Shinwa Tanaka, Takashi Toyonaga, Yoshiko Ohara, Tetsuya Yoshizaki, Fumiaki Kawara, Tsukasa Ishida, Namiko Hoshi, Yoshinori Morita, Takeshi Azuma

  Endoscopic submucosal dissection (ESD) is now widely accepted as a strategy to treat superficial esophageal neoplasms. The rate of adverse events, such as perforation, has been decreasing with the improvement of devices and techniques. In this paper, we report a case of esophageal cancer that had a diverticulum under cancerous epithelium. The diverticulum was not detected during preoperative examination, and led to perforation during the ESD procedure. Our case shows that, although rare, some diverticula can exist underneath the mucosal surface without obvious depression. If there is any sign of hidden diverticula during ESD, surgeons should proceed with caution or, depending on the case, the procedure should be discontinued to avoid adverse events.

  Mar. 2015, World journal of gastroenterology, 21(10) (10), 3121 - 6, English, International magazine

  [Refereed]

  Scientific journal


• Disseminated nocardiosis during systemic steroid therapy for the prevention of esophageal stricture after endoscopic submucosal dissection.

  Tsukasa Ishida, Yoshinori Morita, Namiko Hoshi, Tetsuya Yoshizaki, Yoshiko Ohara, Fumiaki Kawara, Sinwa Tanaka, Yuki Yamamoto, Hiroo Matsuo, Kentaro Iwata, Takashi Toyonaga, Takeshi Azuma

  An 85-year-old man underwent endoscopic submucosal dissection for a large superficial esophageal epithelial neoplasm, which required removal of 95% of the circumference of the esophageal mucosa. Steroids were given orally to prevent esophageal stricture starting on day 3 postoperatively. In the 6th week of steroid treatment, he developed high fever without other symptoms. Chest computed tomography revealed a nodular lesion in the lung. Sputum sample showed Gram-positive, branching, filamentous bacteria, and a diagnosis of nocardiosis was suspected. Brain magnetic resonance imaging revealed multiple focal lesions which indicated dissemination of nocardiosis. Trimethoprim-sulfamethoxazole was immediately started, which led to the disappearance of pulmonary and cerebral nocardiosis with alleviation of fever. Recently, oral steroid treatment has been widely used for the prevention of esophageal stricture. However, the present case indicates the risk of life-threatening infection and the importance of close monitoring of this treatment.

  Mar. 2015, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 27(3) (3), 388 - 91, English, International magazine

  [Refereed]

  Scientific journal


• Endoscopic Submucosal Dissection (ESD) with Additional Therapy for Superficial Esophageal Cancer with Submucosal Invasion.

  Atsuki Ikeda, Namiko Hoshi, Tetsuya Yoshizaki, Yoshimi Fujishima, Tsukasa Ishida, Yoshinori Morita, Yasuo Ejima, Takashi Toyonaga, Yoshihiro Kakechi, Hiroshi Yokosaki, Takeshi Azuma

  OBJECTIVE: The standard treatment for submucosal esophageal cancer is esophagectomy or chemoradiotherapy (CRT). However, these treatment modalities could deteriorate the general condition and quality of life of the patients who are intolerant to invasive therapy. It is therefore important and beneficial to develop less invasive treatment protocols for these patients. METHODS: The study included 43 patients who were clinically suspected of mucosa or submucosal esophageal cancer but underwent endoscopic submucosal dissection (ESD) as a primary treatment, due to the patients' poor performance statuses and/or preferences for less invasive therapy. According to the pathological findings and patient's general condition, whether the patient underwent additional treatments or remained hospitalized without additional treatments was thereafter decided for each patient. We retrospectively analyzed the outcomes of these patients. RESULTS: Fifteen patients underwent additional surgery, 11 patients underwent CRT/radiation therapy (RT) and 17 patients were followed without additional treatments. During the 3-year follow-up period, the relapse-free survival rates in the patients who received or did not receive additional treatments were 88% and 64%, respectively (95% confidence interval, 0.45-0.76, p=0.04). The relapse-free and overall survival rates in the patients with additional treatments were equivalent or superior to those described in previous reports of the standard treatments. Preceding ESD contributed to reduce the local relapse significantly to approximately 3.5% and additional CRT-related toxicities. CONCLUSION: Preceding ESD is very effective for the local control of cancer, and useful for histologically confirming the high-risk factors of relapse, such as ≥submucosal layer 2 (SM2) invasion and lymphovascular involvements. ESD with additional therapy may be a promising strategy for optimizing the selection of therapy depending on the patient's general condition.

  2015, Internal medicine (Tokyo, Japan), 54(22) (22), 2803 - 13, English, Domestic magazine

  [Refereed]

  Scientific journal


• Efficacy of endoscopic submucosal dissection for residual or recurrent superficial colorectal tumors after endoscopic mucosal resection.

  Gabriel Rahmi, Shinwa Tanaka, Yoshiko Ohara, Tsukasa Ishida, Tetsuya Yoshizaki, Yoshinori Morita, Takashi Toyonaga, Takeshi Azuma

  OBJECTIVE: Superficial colorectal tumors can be treated effectively by endoscopic submucosal dissection (ESD). Few data are available on using ESD for residual or recurrent tumors after the first endoscopic resection. This study aimed to evaluate the efficacy of ESD for these lesions. METHODS: In all, 28 patients with residual or recurrent superficial colorectal tumors were referred to the Kobe University Hospital for ESD. The therapeutic outcomes and the possible factors predictive of procedure difficulties for ESD were analyzed. RESULTS: In total, 27 (96.4%) patients were successfully treated using ESD. There was no related immediate complication. One patient had a delayed perforation which was then treated surgically. En bloc R0 resection was possible in all the patients and curative resection in 26 patients (92.9%). One invasive cancer was treated surgically. More than one previous endoscopic resection was the only significant predictive factor for the difficulty in performing ESD. None of the patients experienced recurrence during a follow-up of 22 months (range 3-41 months). CONCLUSIONS: The use of ESD allowed a high rate of en bloc resection for residual or locally recurrent colorectal tumors. Furthermore, these lesions should be treated by ESD as a first-line treatment.

  Jan. 2015, Journal of digestive diseases, 16(1) (1), 14 - 21, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• In vivo MR imaging of porcine gastric ulcer model using intra-cavitary RF coil for MR-endoscope system

  Matsuoka Yuichiro, Morita Yoshinori, Kumamoto Etsuko, Kutsumi Hiromu, Azuma Takeshi, Kuroda Kagayaki

  Sep. 2014, Proceedings of 10th International Interventional MRI Symposium, 40, English

  [Refereed]

  International conference proceedings


• Multi Planar Reconstruction Technique for MR-endoscope System based on Scope Tip Tracking with Gradient Field Sensor

  Takahashi Akihiro, Kumamoto Etsuko, Matsuoka Yuichiro, Morita Yoshinori, Kutsumi Hiromu, Azuma Takeshi, Kuroda Kagayaki

  May 2014, Proceedings of International Society for Magnetic Resonance in Medicine 21th Annual Meeting and Exibition, 2324, English

  [Refereed]

  International conference proceedings


• Endoscopic submucosal dissection for early gastric cancer in anastomosis site after distal gastrectomy.

  Shinwa Tanaka, Takashi Toyonaga, Yoshinori Morita, Tsuyoshi Fujita, Tetsuya Yoshizaki, Fumiaki Kawara, Chika Wakahara, Daisuke Obata, Aya Sakai, Tsukasa Ishida, Nobunao Ikehara, Takeshi Azuma

  Apr. 2014, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 17(2) (2), 371 - 6, English, Domestic magazine

  [Refereed]

  Scientific journal


• Endoscopic submucosal dissection (ESD) versus simplified/hybrid ESD.

  Takashi Toyonaga, Mariko Man-I, Yoshinori Morita, Takeshi Azuma

  The development of endoscopic submucosal dissection (ESD) has enabled en bloc resection of lesions regardless of size and shape. However, ESD of colorectal tumors is technically difficult. Early stage colorectal tumors can be removed by endoscopic mucosal resection (EMR) but larger tumors may require piecemeal resection. Therefore, ESD with snaring has been proposed for more reliable EMR and easier ESD. This is a good option to fill the gap between EMR and ESD, and a good step to the introduction of full ESD.

  Apr. 2014, Gastrointestinal endoscopy clinics of North America, 24(2) (2), 191 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Endoscopic diagnosis of superficial non-ampullary duodenal epithelial tumors in Japan: Multicenter case series.

  Kenichi Goda, Daisuke Kikuchi, Yorimasa Yamamoto, Kengo Takimoto, Naomi Kakushima, Yoshinori Morita, Hisashi Doyama, Takuji Gotoda, Yuji Maehata, Noritsugu Abe

  Apr. 2014, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 26 Suppl 2(Suppl 2) (Suppl 2), 23 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Electrocautery for ESD: settings of the electrical surgical unit VIO300D.

  Yoshinori Morita

  An electrical surgical unit (ESU) performs incisions and coagulation through applying Joule heat, generated by a high-frequency current onto tissue without neuromuscular stimulation. Output by the ESU includes incision output and coagulation output. Incision output is needed to generate a steam explosion (spark) by quickly increasing the intracellular fluid temperature through continuous application of Joule heat generated by the high-frequency current (unmodulated pulse: continuous wave). To perform safe and successful endoscopic submucosal dissection, one must fully understand the principles and features of an ESU to use settings that match the device and to adjust the settings appropriately for each situation.

  Apr. 2014, Gastrointestinal endoscopy clinics of North America, 24(2) (2), 183 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Endoscopic submucosal dissection using a carbon dioxide laser with submucosally injected laser absorber solution (porcine model).

  Daisuke Obata, Yoshinori Morita, Rinna Kawaguchi, Katsunori Ishii, Hisanao Hazama, Kunio Awazu, Hiromu Kutsumi, Takeshi Azuma

  BACKGROUND: Recently, endoscopic submucosal dissection (ESD) has been performed to treat early gastric cancer. The en bloc resection rate of ESD has been reported to be higher than that of conventional endoscopic mucosal resection (EMR), and ESD can resect larger lesions than EMR. However, ESD displays a higher complication rate than conventional EMR. Therefore, the development of devices that would increase the safety of ESD is desired. Lasers have been extensively studied as a possible alternative to electrosurgical tools. However, laser by itself easily resulted in perforation upon irradiation of the gastrointestinal tract. We hypothesized that performing ESD using a CO2 laser with a submucosal laser absorber could be a safe and simple treatment for early gastric cancer. To provide proof of concept regarding the feasibility of ESD using a CO2 laser with submucosally injected laser absorber solution, an experimental study in ex vivo and in vivo porcine models was performed. METHODS: Five endoscopic experimental procedures using a carbon dioxide (CO2) laser were performed in a resected porcine stomach. In addition, three endoscopic experimental procedures using a CO2 laser were performed in living pigs. RESULTS: In the ex vivo study, en bloc resections were all achieved without perforation and muscular damage. In addition, histological evaluations could be performed in all of the resected specimens. In the in vivo study, en bloc resections were achieved without perforation and muscular damage, and uncontrollable hemorrhage did not occur during the procedures. CONCLUSIONS: Endoscopic submucosal dissection using a CO2 laser with a submucosal laser absorber is a feasible and safe method for the treatment of early gastric cancer.

  Nov. 2013, Surgical endoscopy, 27(11) (11), 4241 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Current status of endoscopic diagnosis and treatment of superficial Barrett's adenocarcinoma in Asia-Pacific region.

  Kenichi Goda, Rajvinder Singh, Ichiro Oda, Masami Omae, Akiko Takahashi, Tomoyuki Koike, Noriya Uedo, Dai Hirasawa, Mitsuhiro Fujishiro, Kingo Hirasawa, Yoshinori Morita, Lawrence K Y Ho, Yoichi Ajioka

  The incidence of Barrett's adenocarcinoma has increased dramatically over the past few decades in most Western countries. While Barrett's esophagus is uncommon and adenocarcinoma is still rare in Asian populations, several Asian studies have indicated that the prevalence of esophageal adenocarcinoma is gradually increasing. Therefore, in order to determine the best way to treat superficial Barrett's adenocarcinoma, 12 expert endoscopists and a pathologist from the Asia-Pacific region conducted a session entitled 'The current status of endoscopic diagnosis and treatment of superficial Barrett's adenocarcinoma'. After three keynote lectures, three Japanese panels presented cases of superficial Barrett's adenocarcinomas diagnosed by image-enhanced endoscopy (IEE). We then confirmed the results of a questionnaire on the diagnosis and treatment of superficial Barrett's adenocarcinomas. Finally, a panel introduced an Asia-Pacific international study on simplified narrow-band imaging (NBI) classification of Barrett's esophagus and neoplasias. After a discussion, we proposed consensus statements on endoscopic diagnosis and treatment of superficial Barrett's adenocarcinoma as follows. Representative characteristics by conventional white light endoscopy are a reddish area or a lesion located on the anterior to right side wall. IEE may be useful for characterizing the tumor and diagnosing lateral tumor extension. Superficial Barrett's adenocarcinoma adjacent to the squamocolumnar junction is sometimes associated with subsquamous tumor extension. IEE may be useful to detect the subsquamous tumor extension especially when using NBI or an acetic acid-spraying method. Endoscopic mucosal resection or endoscopic submucosal dissection for mucosal carcinomas could provide excellent prognosis.

  May 2013, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 25 Suppl 2, 146 - 50, English, International magazine

  [Refereed]

  Scientific journal


• Endoscopic vessel sealing: a novel endoscopic precoagulation technique for blood vessels during endoscopic submucosal dissection.

  Shinwa Tanaka, Takashi Toyonaga, Yoshinori Morita

  May 2013, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 25(3) (3), 341 - 2, English, International magazine

  [Refereed]

  Scientific journal


• Barrett's adenocarcinoma in long-segment Barrett's esophagus successfully detected by narrow-band imaging with magnifying endoscopy.

  Yoshinori Morita, Shinwa Tanaka, Takashi Toyonaga, Takeshi Azuma

  Conventionally, long-segment Barrett's esophagus (LSBE) has been considered a high-risk background for the occurrence of Barrett's adenocarcinoma in Western countries, and random biopsy has been proposed for surveillance, aiming to detect early cancer. However, accurate detection of a lesion and diagnosis of the expansion are difficult by this blind method. Herein, we report a case of early Barrett's adenocarcinoma derived from LSBE that was successfully detected by narrow-band imaging with magnifying endoscopy.

  May 2013, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 25 Suppl 2(Suppl 2) (Suppl 2), 201 - 5, English, International magazine

  [Refereed]

  Scientific journal


• 内視鏡切除後遠隔転移を来たしたLST-NG(偽陥凹型)の一例

  奥野 達哉, 池原 伸直, 吉崎 哲也, 河原 史明, 池田 篤紀, 坂井 文, 藤島 佳美, 田中 心和, 石田 司, 鎮西 亮, 三木 章, 矢野 嘉彦, Morita Yoshinori, 瀬尾 靖, Hara Shigeo, 豊永 高史, 横崎 宏, 東 健

  (一社)日本消化器内視鏡学会, Apr. 2013, Gastroenterological Endoscopy, 55(Suppl.1) (Suppl.1), 1124 - 1124, Japanese

  Research society


• Lifestyle factors associated with gastroesophageal reflux disease in the Japanese population.

  Nobuyuki Matsuki, Tsuyoshi Fujita, Naoya Watanabe, Atsushi Sugahara, Akihiko Watanabe, Tsukasa Ishida, Yoshinori Morita, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Hidekazu Mukai, Takeshi Azuma

  BACKGROUND: We aimed to clarify the lifestyle factors associated with erosive esophagitis and non-erosive reflux disease (NERD) in a Japanese population. METHODS: Among 886 subjects who underwent health screening, we selected, according to their scores on the FSSG (frequency scale for symptoms of gastroesophageal reflux disease; GERD) questionnaire and the findings of upper gastrointestinal endoscopy, 138 subjects with erosive esophagitis (EE), 148 subjects with NERD (absence of esophagitis, FSSG score ≥8, and acid reflux-related symptoms score ≥4), and 565 control subjects (absence of esophagitis and FSSG score ≤7). We compared clinical characteristics and various lifestyle factors in these three groups. RESULTS: The lifestyle factors significantly associated with NERD compared with findings in the control group were intake of egg (odds ratio [OR] 1.89, 95% confidence interval [CI] 1.01-3.50), sleep shortage (OR 2.44, 95% CI 1.54-3.88), and strong psychological stress (OR 1.77, 95% CI 1.18-2.62). In male subjects, current smoking (OR 2.06, 95% CI 1.13-3.74; OR 1.87, 95% CI 1.09-3.20) was a significant risk factor for both NERD and EE. Moreover, alcohol >200 kcal/day (OR 3.99, 95% CI 1.03-15.55) and intake of a large quantity of food at supper (OR 7.85, 95% CI 1.66-37.05) were significant risk factors for EE in subjects with hiatal hernia. Intake of a large quantity of food at supper (OR 2.09, 95% CI 1.06-4.13) was more common in the NERD group than in the EE group. CONCLUSIONS: There were differences in the associated lifestyle factors between patients with NERD and those with EE, and there was also a gender-related difference between these groups.

  Mar. 2013, Journal of gastroenterology, 48(3) (3), 340 - 9, English, Domestic magazine

  [Refereed]

  Scientific journal


• Endoscopic submucosal dissection for gastric neoplasm in patients with co-morbidities categorized according to the ASA Physical Status Classification.

  Mariko Man-i, Yoshinori Morita, Tsuyoshi Fujita, James E East, Shinwa Tanaka, Chika Wakahara, Masaru Yoshida, Takanobu Hayakumo, Hiromu Kutsumi, Hideto Inokuchi, Takashi Toyonaga, Takeshi Azuma

  BACKGROUND: Endoscopic submucosal dissection (ESD) has come to be widely performed for reduced invasiveness; however, its safety in patients with co-morbidities is not fully examined. We aimed to evaluate the safety and efficacy of gastric ESD with co-morbidities categorized according to ASA Physical Status Classification. METHODS: Two hundred and forty patients of ASA 1 (no co-morbidities), 268 of ASA 2 (mild), and 19 of ASA 3 (severe) were treated by ESD for gastric neoplasms. We retrospectively compared clinicopathological features and treatment results of these three groups. RESULTS: Cases (by percent) treated with anticoagulant/platelet agents were more common in the higher ASA grades (ASA 1, 5.8%; ASA 2, 29.1%; ASA 3, 31.6%; P < 0.0001). There were no significant differences in case numbers treated under guideline criteria, curative resection (ASA 1, 79.6%; ASA 2, 79.9%; ASA 3, 78.9%), or complications related to the ESD procedure (e.g., postoperative bleeding, perforation, thermal injury). By a patient risk prediction model on surgery, i.e., P-POSSUM, morbidity was halved, and no patients died compared to a predicted death rate of 0.5-2%; however, total and complications unrelated to ESD procedure (e.g., aspiration pneumonia, ischemic heat attack) were more common in higher ASA grades (ASA 1, ASA 2, ASA 3: 15.4, 23.9, 26.3%, respectively, P = 0.014; 0.4, 7.1, 0%, respectively, P = 0.00087). Deviation rates from clinical pathway were more frequent and hospital stay (days) longer in higher ASA grades (ASA 1, ASA 2, ASA 3: 11.3, 17.9, 26.3%, respectively, P = 0.014; 8, 8, 9%, respectively, P = 0.0053). CONCLUSIONS: ESD is an efficient treatment for gastric neoplasms with co-morbidities. However, additional caution is required because co-morbidity is a risk factor for both total complications and complications unrelated to the ESD procedure, and may cause deviations in the clinical course and prolonged hospital stay.

  Jan. 2013, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 16(1) (1), 56 - 66, English, Domestic magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• Navigation technique for MR-endoscope system using a wireless accelerometer-based remote control device.

  Etsuko Kumamoto, Akihiro Takahashi, Yuichiro Matsuoka, Yoshinori Morita, Hiromu Kutsumi, Takeshi Azuma, Kagayaki Kuroda

  The MR-endoscope system can perform magnetic resonance (MR) imaging during endoscopy and show the images obtained by using endoscope and MR. The MR-endoscope system can acquire a high-spatial resolution MR image with an intraluminal radiofrequency (RF) coil, and the navigation system shows the scope's location and orientation inside the human body and indicates MR images with a scope view. In order to conveniently perform an endoscopy and MR procedure, the design of the user interface is very important because it provides useful information. In this study, we propose a navigation system using a wireless accelerometer-based controller with Bluetooth technology and a navigation technique to set the intraluminal RF coil using the navigation system. The feasibility of using this wireless controller in the MR shield room was validated via phantom examinations of the influence on MR procedures and navigation accuracy. In vitro examinations using an isolated porcine stomach demonstrated the effectiveness of the navigation technique using a wireless remote-control device.

  2013, Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2013, 5698 - 701, English, International magazine

  [Refereed]

  Scientific journal


• High-resolution MR imaging of gastrointestinal tissue by intracavitary RF coil with remote tuning and matching technique for integrated MR-endoscope system.

  Yuichiro Matsuoka, Akihiro Takahashi, Etsuko Kumamoto, Yoshinori Morita, Hiromu Kutsumi, Takeshi Azuma, Kagayaki Kuroda

  The goal of this study is to establish novel medical technologies by combining magnetic resonance imaging (MRI) with endoscopy to improve diagnostic precision and the safety of endoscopic surgeries. One of the key components of the integrated magnetic resonance (MR) endoscope system is a radio-frequency (RF) coil; this detects the MR signal from tissue and should be placed inside the body. Resonance characteristics such as the resonant frequency and the impedance of the RF coil, which affect the quality of MR images, change depending on the electric properties of the surrounding tissue and the coil deformation. Therefore, the technique of remote tuning and matching of the RF coil was developed, and its feasibility was investigated using a developed intracavitary RF coil, 1.5 tesla MR scanner, and models of phantom and resected porcine stomach. As a result, the frequency tuning and impedance matching was remotely adjusted in both models. In addition, the signal-to-noise ratio (SNR) of MR images was improved up to 134%. The developed remote tuning and matching technique was able to adjust the resonant characteristics of RF coil and can contribute the improvement of MR image quality, which would facilitate safe and precise endoscopy and endoscopic surgeries.

  2013, Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2013, 5706 - 10, English, International magazine

  [Refereed]

  Scientific journal


• PPIによる維持療法を行っているGERD患者の臨床的特徴

  Fujita Tsuyoshi, Ishida Tsukasa, Morita Yoshinori, Yano Yoshihiko, Okuno Tatsuya, Ooi Makoto, Kutsumi Hiromu, Hayakumo Takanobu, Azuma Takeshi

  (一財)日本消化器病学会, Sep. 2012, 日本消化器病学会雑誌, 109(臨増大会) (臨増大会), A769 - A769, Japanese

  Research society


• Navigation for adequate MR scan with integrated MR-endoscope system using intraluminal RF coil

  Yuuichiro Matsuoka, Takahashi Akihiro, Kumamoto Etsuko, Morita Yoshinori, Takenaka Mamoru, Sakai Aya, Kutsumi Hiromu, Azuma Takeshi, Kuroda Kagayaki

  Sep. 2012, Proceedings of 9th International Interventional MRI Symposium, 143, English

  [Refereed]

  International conference proceedings


• Ex vivo pig training model for esophageal endoscopic submucosal dissection (ESD) for endoscopists with experience in gastric ESD.

  Shinwa Tanaka, Yoshinori Morita, Tsuyoshi Fujita, Chika Wakahara, Atsuki Ikeda, Takashi Toyonaga, Takeshi Azuma

  BACKGROUND: Esophageal endoscopic submucosal dissection (ESD) has developed in recent years because of its high rate of en bloc resection. However, for many endoscopists, technical difficulty and risks of complications are great barriers to performing esophageal ESD. In this study, we developed an original training model for esophageal ESD using isolated pig esophagus and assessed this ex vivo model in endoscopists with experience in gastric ESD. METHODS: Three endoscopists without experience in esophageal ESD but with some experience in gastric ESD performed esophageal ESD of artificial lesions in 10 consecutive sessions using this ex vivo model. The en bloc resection rate, operation time, number of muscularis propria layer injuries, and presence of perforation were recorded. We evaluated the effectiveness of this training in the three endoscopists by comparing results from the first five sessions (former period) with those from the last five sessions (latter period). RESULTS: All three endoscopists achieved en bloc resections in all trials. In the former period, injury to the muscularis propria layer for each of the three endoscopists occurred a mean of 2.2 (1-3), 0.6 (0-1), and 3.2 (1-6) times, respectively. Perforation occurred in one session performed by one endoscopist. In the latter period, the mean number of muscularis propria layer injuries for each of the three endoscopists decreased to 0.2 (0-1), 0.2 (0-1), and 0.8 (0-2), respectively. The time of operation shortened from 35.0 (25-40), 36.4 (30-50), and 29.8 (23-43) min to 23.0 (16-31), 25.6 (23-28), and 29.2 (21-37) min, respectively. CONCLUSIONS: This original ex vivo training model was helpful to endoscopists with experience in gastric ESD in acquiring the basic skills for performing esophageal ESD.

  Jun. 2012, Surgical endoscopy, 26(6) (6), 1579 - 86, English, International magazine

  [Refereed]

  Scientific journal


• Desirable training and roles of Japanese endoscopists towards the further penetration of endoscopic submucosal dissection in Asia.

  Mitsuhiro Fujishiro, Hwoon-Yong Jung, Kenichi Goda, Kingo Hirasawa, Naomi Kakushima, I-Lin Lee, Yoshinori Morita, Ichiro Oda, Manabu Takeuchi, Yorimasa Yamamoto, Ping-Hong Zhou, Noriya Uedo

  Endoscopic submucosal dissection (ESD) was invented in Japan and is now permeating into the rest of the world. Therefore, it is necessary to elucidate the desirable ESD training by knowing the current status of ESD training in Japan. After this, we mainly discussed the following three topics: (i) requirements for preceptees to start ESD training; (ii) requirements for competent endoscopists in ESD; and (iii) requirements for preceptors in the first half of the upper gastrointestinal tract session at the Endoscopic Forum Japan 2011. Additionally, we discussed what Japanese endoscopists can do for further permeation of ESD outside Japan, especially in Asia in the second half. The session was wrapped up by the conclusions that it was absolutely necessary to establish official training courses authorized by the Japan Gastroenterological Endoscopy Society with certification for trainees and trainers and our Japanese endoscopists had a responsibility to spread ESD safely and reliably by collaborating with enthusiastic endoscopists in each country which have different backgrounds in terms of incidences and screening systems of target diseases, accessibility to endoscopy, medical economics, national characters, and so on.

  May 2012, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 24 Suppl 1, 121 - 3, English, International magazine

  [Refereed]

  Scientific journal


• Terminology for training of endoscopic submucosal dissection.

  Naomi Kakushima, Kingo Hirasawa, Yoshinori Morita, Manabu Takeuchi, Yorimasa Yamamoto, Ichiro Oda, Kenichi Goda, Noriya Uedo, Mitsuhiro Fujishiro

  Like many other advanced endoscopic skills, to master the skill of endoscopic submucosal dissection (ESD) requires training for a novice. The general medical terminology should be used similarly even in case of ESD training. However, it is not common for everyone to recall the same meaning from one medical term. Therefore, it is necessary to unify the meaning of medical terms and review their usage in a meeting to achieve a consensus. For this purpose, terms used in the upper gastrointestinal session, Endoscopic Forum Japan 2011, entitled 'Towards further penetration of ESD techniques - what is the role of Japanese ESD experts?', were determined beforehand as shown. Additionally, the present educational approach of ESD in Japan is simply outlined in this article.

  May 2012, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 24 Suppl 1, 133 - 5, English, International magazine

  [Refereed]

  Scientific journal


• How to teach and learn endoscopic submucosal dissection for upper gastrointestinal neoplasm in Japan.

  Kenichi Goda, Mitsuhiro Fujishiro, Kingo Hirasawa, Naomi Kakushima, Yoshinori Morita, Ichiro Oda, Manabu Takeuchi, Yorimasa Yamamoto, Noriya Uedo

  BACKGROUND: Endoscopic submucosal dissection (ESD) is an innovative and promising procedure. However, ESD experience is mostly limited to Japan and a few countries in Asia. An appropriate training system should be proposed from Japan to promote a permeation of ESD technique. We conducted questionnaire survey to representative Japanese experts to reveal their training method of ESD for upper gastrointestinal neoplasm. MATERIALS AND METHODS: We sent the questionnaire on gastric and esophageal ESD to 9 Japanese experts in ESD. The questionnaire results were discussed in a session of Endoscopic Forum Japan 2011 held in Tokyo. RESULTS: The inception criteria consisted of two main elements, diagnostic ability and primary endoscopy technique of preceptees. Preceptees should observe and attend as many ESD cases as possible. Most of the experts recommend training with isolated or live animal stomach or esophagus. Lesion in the distal stomach is the most suitable for the first real ESD by a preceptee. Being proficient in a gastric ESD is needed before starting esophageal ESD. Preceptor should have significantly high level of diagnostic ability and proficient ESD techniques in the colorectum as well as the stomach and esophagus. CONCLUSION: The present questionnaire survey seems to reveal basic elements required for ESD training program. We believe that this is also helpful in other countries where ESD would be initiated and penetrated safely and properly.

  May 2012, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 24 Suppl 1, 136 - 42, English, International magazine

  [Refereed]

  Scientific journal


• Endoscopic double-layered suturing: a novel technique for closure of large mucosal defects after endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD)

  S. Tanaka, T. Toyonaga, D. Obata, T. Ishida, Y. Morita, T. Azuma

  May 2012, ENDOSCOPY, 44(Suppl 2 UCTN) (Suppl 2 UCTN), E153 - E154, English

  [Refereed]

  Scientific journal


• Navigation of Quick MR Scanning Setup with Intraluminal RF Coil for Integrated MR-Endoscope System

  Matsuoka Yuichiro, Kumamoto Etsuko, Takahashi Akihiro, Morita Yoshinori, Kutsumi Hiromu, Azuma Takeshi, Kuroda Kagayaki

  May 2012, Proceedings of International Society for Magnetic Resonance in Medicine 20th Annual Meeting and Exibition, 1590, English

  [Refereed]

  International conference proceedings


• 内視鏡治療における偶発症の対処法 食道・胃病変 食道ESDにおける偶発症とその対処法

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2012, Gastroenterological Endoscopy, 54(Suppl.1) (Suppl.1), 890 - 890, Japanese

  Symposium


• Magnifying endoscopy in upper gastroenterology for assessing lesions before completing endoscopic removal.

  Ning-Li Chai, En-Qiang Ling-Hu, Yoshinori Morita, Daisuke Obata, Takashi Toyonaga, Takeshi Azuma, Ben-Yan Wu

  Any prognosis of gastrointestinal (GI) cancer is closely related to the stage of the disease at diagnosis. Endoscopic submucosal dissection (ESD) and en bloc endoscopic mucosal resection (EMR) have been performed as curative treatments for many early-stage GI lesions in recent years. The technologies have been widely accepted in many Asian countries because they are minimally invasive and supply thorough histopathologic evaluation of the specimens. However, before engaging in endoscopic therapy, an accurate diagnosis is a precondition to effecting the complete cure of the underlying malignancy or carcinoma in situ. For the past few years, many new types of endoscopic techniques, including magnifying endoscopy with narrow-band imaging (ME-NBI), have emerged in many countries because these methods provide a strong indication of early lesions and are very useful in determining treatment options before ESD or EMR. However, to date, there is no comparable classification equivalent to "Kudo's Pit Pattern Classification in the colon", for the upper GI, there is still no clear internationally accepted classification system of magnifying endoscopy. Therefore, in order to help unify some viewpoints, here we will review the defining optical imaging characteristics and the current representative classifications of microvascular and microsurface patterns in the upper GI tract under ME-NBI, describe the accurate relationship between them and the pathological diagnosis, and their clinical applications prior to ESD or en bloc EMR. We will also discuss assessing the differentiation and depth of invasion, defying the lateral spread of involvement and targeting biopsy in real time.

  Mar. 2012, World journal of gastroenterology, 18(12) (12), 1295 - 307, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal


• 炭酸ガスレーザーを用いた消化器がんに対する内視鏡的粘膜下層剥離術の開発

  山田啓一郎, 石井克典, 間久直, 小畑大輔, 森田圭紀, 久津見弘, 東健, 粟津邦男

  Mar. 2012, 電気学会研究会資料, Japanese

  Research society


• MR内視鏡システムによる新たな内視鏡的治療支援技術の開発

  Morita Yoshinori, Matsuoka Yuichiro, Azuma Takeshi

  (一財)日本消化器病学会, Mar. 2012, 日本消化器病学会雑誌, 109(臨増総会) (臨増総会), A251 - A251, Japanese

  Symposium


• Clinicopathological characteristics of abnormal micro-lesions at the oro-hypopharynx detected by a magnifying narrow band imaging system.

  Shinwa Tanaka, Yoshinori Morita, Tsuyoshi Fujita, Hiroshi Yokozaki, Daisuke Obata, Shoko Fujiwara, Chika Wakahara, Atsuhiro Masuda, Maki Sugimoto, Tsuyoshi Sanuki, Masaru Yoshida, Takashi Toyonaga, Hiromu Kutsumi, Takeshi Azuma

  BACKGROUND: Narrow band imaging (NBI) with magnifying endoscopy (NBI-ME) allows the detection of abnormal micro-lesions smaller than 5 mm in diameter in the oro-hypopharynx that could not be visualized previously. The purpose of the present study was to clarify the clinicopathological characteristics of abnormal micro-lesions of the oro-hypopharynx detected by NBI-ME. METHODS: Of the 62 lesions detected by NBI-ME, 40 abnormal micro-lesions in 37 patients were removed by endoscopic treatment and were pathologically evaluated. We reviewed the medical records of patients with these lesions and investigated the relationship between NBI-ME findings and pathological findings. RESULTS: Pathological examination revealed the following: high-grade intraepithelial neoplasia (HGIN) in nine (23%) lesions, low-grade intraepithelial neoplasia (LGIN) in 22 (55%), pharyngitis in seven (18%) and papilloma in two (5%). Two NBI-ME findings, high microvascular density (MVD) and a brownish area (BA), were recognized more frequently as the grade of malignancy advanced. The likelihood ratio (confidential interval) for having HGIN in the patients with both MVD and BA was 13 (3.62-127). CONCLUSIONS: The pathological diagnosis of abnormal micro-lesions ranged from pharyngitis to HGIN. High MVD and BA may be important findings for grading the malignancy of abnormal micro-lesions.

  Mar. 2012, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 24(2) (2), 100 - 9, English, International magazine

  [Refereed]

  Scientific journal


• CO2レーザーを用いた安全な内視鏡的粘膜下層剥離術の開発

  山田 啓一郎, 石井 克典, 間 久直, 小畑 大輔, 森田 圭紀, 久津見 弘, 東 健, 粟津 邦男

  (NPO)日本レーザー医学会, Feb. 2012, 日本レーザー医学会誌, 32(4) (4), 521 - 521, Japanese


• CO2レーザーによる新たな内視鏡技術の開発

  森田圭紀, 小畑大輔, 東健, 石井克典, 間久直, 粟津邦男

  Jan. 2012, Japanese

  [Invited]

  Research society


• 炭酸ガスレーザーを用いた内視鏡下での消化器がん剥離治療法の開発

  山田啓一郎, 石井克典, 間久直, 小畑大輔, 森田圭紀, 久津見弘, 東健, 粟津邦男

  Jan. 2012, Japanese

  Research society


• Conflicting clinical environment about the management of antithrombotic agents during the periendoscopic period in Japan.

  Satoshi Ono, Mitsuhiro Fujishiro, Hiromitsu Kanzaki, Noriya Uedo, Chizu Yokoi, Junichi Akiyama, Masaki Sugawara, Ichiro Oda, Shoko Suzuki, Yoshiyuki Fujita, Shunsuke Tsubata, Masaaki Hirano, Masakatsu Fukuzawa, Mikinori Kataoka, Toshiro Kamoshida, Shinji Hirai, Tetsuya Sumiyoshi, Hitoshi Kondo, Yorimasa Yamamoto, Kazuhisa Okada, Yoshinori Morita, Shoko Fujiwara, Shinji Morishita, Masao Matsumoto, Kazuhiko Koike

  BACKGROUND AND AIMS: Although there are guidelines for the management of antithrombotic agents during the periendoscopic period, gaps between various guidelines create a confusing situation in daily clinical practice. The purpose of this study was to examine the current management of antithrombotic agents during the periendoscopic period in Japan. METHODS: This is a prospective cohort study in 12 high-volume endoscopy centers in Japan. A total of 970 outpatients receiving antithrombotic agents underwent endoscopies (705 esophagogastroduodenoscopies and 265 colonoscopies) with or without invasive procedures. Main outcome measures are adverse events in these patients. RESULTS: Need for cessation of antithrombotics before endoscopy was mostly determined by non-gastroenterologists (51%) who are unfamiliar with the Japan Gastroenterological Endoscopy Society (JGES) guideline, although cessation periods after endoscopy for most patients were determined by endoscopists (78%). Consequently, most patients underwent endoscopy without cessation (25%) or after a cessation period of 6-7 days (33%), indicating low permeation of the JGES guideline in Japan. Among 970 patients, two patients experienced major complications that may be related to thromboembolic events or gastrointestinal bleeding (95% confidence interval [CI]: 0-0.7%). One of these patients died due to sudden onset ventricular tachycardia. Invasive procedures, including 40 biopsies and two mucosal resections, were performed in 42 patients without cessation of antithrombotics, and no patients experienced major complications (95% CI: 0-8.4%). CONCLUSIONS: This study revealed a conflicting clinical environment due to absence of a unified guideline in Japan. Further accumulation of data is mandatory to establish a unified guideline based upon solid evidence.

  Sep. 2011, Journal of gastroenterology and hepatology, 26(9) (9), 1434 - 40, English, International magazine

  [Refereed]

  Scientific journal


• 微小癌の診断におけるNBI併用拡大観察の有用性

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2011, Gastroenterological Endoscopy, 53(Suppl.2) (Suppl.2), 2614 - 2614, Japanese

  International conference proceedings


• 内視鏡手術の新展開 光吸収剤とCO2レーザーによる新たなESD技術の開発

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2011, Gastroenterological Endoscopy, 53(Suppl.2) (Suppl.2), 2487 - 2487, Japanese

  International conference proceedings


• 当院でのclinical stageI食道表在癌の内科的及び外科的治療成績の検討

  Morita Yoshinori, Nakamura Tetsu, Nishimura Hideki, Kuroda Daisuke, Azuma Takeshi

  (NPO)日本食道学会, Sep. 2011, 日本食道学会学術集会プログラム・抄録集65回, 65回, 200 - 200, Japanese

  International conference proceedings


• 直腸亜全周粘膜切除後の狭窄予防にトリアムシノロン局注が有用であった1例

  Tanaka Shinwa, Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2011, Gastroenterological Endoscopy, 53(Suppl.2) (Suppl.2), 2664 - 2664, Japanese

  International conference proceedings


• 直腸LSTの診断と治療の最前線 直腸LSTにおけるESDの有用性について

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2011, Gastroenterological Endoscopy, 53(Suppl.2) (Suppl.2), 2527 - 2527, Japanese

  International conference proceedings


• 食道ESD後狭窄予防に対するステロイド局注の投与間隔に関する検討

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2011, Gastroenterological Endoscopy, 53(Suppl.2) (Suppl.2), 2783 - 2783, Japanese

  International conference proceedings


• da Vinci robotic single-incision cholecystectomy and hepatectomy using single-channel GelPort access.

  Maki Sugimoto, Koichi Tanaka, Yuichiro Matsuoka, Mari Man-i, Yoshinori Morita, Shinwa Tanaka, Shoko Fujiwara, Takeshi Azuma

  Jul. 2011, Journal of hepato-biliary-pancreatic sciences, 18(4) (4), 493 - 8, English, Domestic magazine

  [Refereed]

  Scientific journal


• Role of narrow band imaging for diagnosis of early-stage esophagogastric cancer: current consensus of experienced endoscopists in Asia-Pacific region.

  Noriya Uedo, Mitsuhiro Fujishiro, Kenichi Goda, Dai Hirasawa, Yoshiro Kawahara, Jun H Lee, Ryoji Miyahara, Yoshinori Morita, Rajvinder Singh, Manabu Takeuchi, Shufang Wang, Takashi Yao

  In Asian countries, squamous cell carcinoma is the most common type of esophageal cancer, and the incidence of gastric cancer remains have plateaued. To synthesize current information and to illustrate its clinical benefit of narrow band imaging (NBI) for diagnosis of superficial esophageal squamous carcinoma (SESCC) and early gastric cancer (EGC), a consensus conference was held by a panel of nine experts from Asian-Pacific countries. The expert's agreement suggested importance of interpretation of both vascular architecture and surface structure of the lesions and proper processor settings for endoscopic images. Zoom endoscopy was not regarded as absolutely necessary for detection of SESCC, but magnifying observation provided valuable information for characterization of detected lesions in the esophagus and the stomach. In general, NBI is useful for detection and characterization of SESCC, whereas it is beneficial mainly for characterization of EGC. Chromoendoscopy was found to be still worthwhile in certain situations, such as determination of the extent of SESCC by Lugol's staining, or detection and delineation of EGC by indigo carmine. NBI could replace chromoendoscopy in routine examination because it is easy to use and adds much information to conventional WLI, but it cannot eliminate chromoendoscopy when we make a final diagnosis for treatment decision-making. Consequently, the benefit of NBI or magnifying NBI is specific for the organ and the purpose of the examination, thus optimum indication and usage should be understood for maximum clinical benefit.

  May 2011, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 23 Suppl 1, 58 - 71, English, International magazine

  [Refereed]


• The usefulness of NBI magnification on diagnosis of superficial esophageal squamous cell carcinoma.

  Yoshiro Kawahara, Noriya Uedo, Mitsuhiro Fujishiro, Ken-ichi Goda, Dai Hirasawa, Jun Haeng Lee, Ryoji Miyahara, Yoshinori Morita, Rajvinder Singh, Manabu Takeuchi, Shufang Wang, Takashi Yao

  Reported herein is the case of a 80-year-old man who had small squamous cell carcinoma in the esophagus. The lesion was initially detected as a irregular reddish elevated and flat area depicted by non-magnified white light endoscopy and observed as a brownish area with the narrow-band imaging system (NBI). The depth of elevated and depressed area in the lesion was predicted to be LSM to MM due to Inoue's classification of morphologic change of intrapapillary capillary loop (IPCL) under magnified NBI observation. The depth of another flat area was not able to predicted by Inoue's classification, and we used Arima's classification. We predicted the depth of invasion to be MM to SM1.by this classification. Endoscopic submucosal dissection (ESD) was carried out for the lesion. As a result, the endoscopic diagnosis completely accorded with pathological diagnosis. We could diagnose correctly by adding Arima's classification to Inoue's classification.

  May 2011, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 23 Suppl 1, 79 - 82, English, International magazine

  [Refereed]

  Scientific journal


• A randomized controlled trial of rebamipide plus rabeprazole for the healing of artificial ulcers after endoscopic submucosal dissection.

  Shoko Fujiwara, Yoshinori Morita, Takashi Toyonaga, Fumi Kawakami, Tomoo Itoh, Masaru Yoshida, Hiromu Kutsumi, Takeshi Azuma

  May 2011, Journal of gastroenterology, 46(5) (5), 595 - 602, English, Domestic magazine

  [Refereed]

  Scientific journal


• A case of small early gastric cancer that was successfully detected by narrow band imaging magnifying endoscopy.

  Yoshinori Morita, Shoko Fujiwara, Shinwa Tanaka, Takashi Toyonaga, Takeshi Azuma

  May 2011, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 23 Suppl 1, 89 - 91, English, International magazine

  [Refereed]

  Scientific journal


• 大腸癌内視鏡治療穿孔症例に対する緊急手術の適応とその方法

  Nakamura Tetsu, Morita Yoshinori, Kuroda Daisuke

  (一社)日本大腸肛門病学会, Apr. 2011, 日本大腸肛門病学会雑誌, 64(4) (4), 304 - 304, Japanese

  International conference proceedings


• 内視鏡関連機器の進歩と課題 光吸収剤とCO2レーザーによる新たなESD技術の開発

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Mar. 2011, Gastroenterological Endoscopy, 53(Suppl.1) (Suppl.1), 675 - 675, Japanese

  International conference proceedings


• 当院における表在型食道癌ESD後術後狭窄に対する治療戦略

  Morita Yoshinori

  (一社)日本消化器内視鏡学会, Mar. 2011, Gastroenterological Endoscopy, 53(Suppl.1) (Suppl.1), 871 - 871, Japanese

  Scientific journal


• 大腸ESD:保険適応への課題 大腸腫瘍に対する内視鏡治療法の検討

  Tanaka Shinwa, Morita Yoshinori

  (一社)日本消化器内視鏡学会, Mar. 2011, Gastroenterological Endoscopy, 53(Suppl.1) (Suppl.1), 689 - 689, Japanese

  International conference proceedings


• 卒後内視鏡教育の課題と対応 ESDの安全確実な普及を目指して

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Mar. 2011, Gastroenterological Endoscopy, 53(Suppl.1) (Suppl.1), 664 - 664, Japanese

  International conference proceedings


• ブタの切除食道を用いた食道ESDのトレーニングの検討

  Tanaka Shinwa, Morita Yoshinori

  (一社)日本消化器内視鏡学会, Mar. 2011, Gastroenterological Endoscopy, 53(Suppl.1) (Suppl.1), 870 - 870, Japanese

  International conference proceedings


• ESD困難例の克服 広範囲食道表在癌に対するESDにおける当院での治療戦略

  Morita Yoshinori

  (一社)日本消化器内視鏡学会, Mar. 2011, Gastroenterological Endoscopy, 53(Suppl.1) (Suppl.1), 758 - 758, Japanese

  International conference proceedings


• biweekly CPT-11 CDDP併用療法で長期生存を得た早期胃癌ESD後再発の1例

  Morita Yoshinori, Kuroda Daisuke, Azuma Takeshi

  (一社)日本胃癌学会, Mar. 2011, 日本胃癌学会総会記事83回, 83回, 288 - 288, Japanese

  International conference proceedings


• Selective Incision of Mucosa and Less-Invasive Dissection of Sub-Mucosa Using Carbon Dioxide Laser : Translational Research from Basic Laser Tissue Interaction to Clinical Research

  ISHII Katsunori, OBATA Daisuke, HAZAMA Hisanao, WATANABE Satoshi, YAMADA Keiichiro, TERADA Takaya, MORITA Yoshinori, KUTSUMI Hiromu, AZUMA Takeshi, AWAZU Kunio

  Endoscopic submucosal dissection (ESD) has attracted a great deal of attention as a new treatment for

  The Laser Society of Japan, Feb. 2011, The Review of Laser Engineering, 39(2) (2), 111 - 117, Japanese

  [Refereed]


• Surveillance after colorectal polypectomy; comparison between Japan and U.S.

  Shinwa Tanaka, Daisuke Obata, Ryo Chinzei, Shiei Yoshida, Tuyoshi Sanuki, Yoshinori Morita, Masaru Yoshida, Tsuyoshi Fujita, Takashi Toyonaga, Hiromu Kutsumi, Hideto Inokuchi, Takeshi Azuma

  BACKGROUND: Recently, early detection and early treatment of the colorectal cancer have been enabled by the improvement of endoscopic diagnosis and introduction of new techniques. In Japan, although Japan Polyp Study is running, there is no standard strategy concerning the post-polypectomy colonoscopic surveillance yet. Post-polypectomy colonoscopic surveillance is so far entrusted to each institute or each gastroenterologist at present. MATERIAL AND METHOD: To analyze the present states of the surveillance after polypectomy in Japan, we performed questionary survey and compared them with the results in U.S. and U.S. Multisociety Task Force on colorectal Cancer. A simple random sample of 132 doctors who engaged in a digestive organ disease in plural institutes was obtained. RESULT: Many doctors recommend surveillance every around 1 year regardless of the kind of the polyp. Doctors in Japan tend to recommend postpolypectomy colonoscopic surveillance more frequently than that recommended U.S. Multisociety Task Force on colorectal Cancer. Furthermore in all types of polyps except for 12 mm tubular adenoma with high grade dysplasia, the majority of doctors in Japan recommend post-polypectomy colonoscopic surveillance more frequently than American doctors. Significant difference was found in surveillance of hyperplastic polyp among doctors with 1 to 5 years experience and those with more than 6 years. CONCLUSION: It has been shown that surveillance intervals varies substantially in each doctor. The agreement of the surveillance program in Japan is necessary to standardize the strategy for the post-polypectomy surveillance of the colon.

  Feb. 2011, The Kobe journal of medical sciences, 56(5) (5), E204-13, English, Domestic magazine

  [Refereed]

  Scientific journal


• 炭酸ガスレーザーによる選択的粘膜層切開および粘膜下層剥離～基礎的相互作用を機器開発および臨床応用へ橋渡し～

  石井克典, 小畑大輔, 渡辺聡, 山田啓一郎, 間久直, 森田圭紀, 久津見弘, 東健, 粟津邦男

  Feb. 2011, Japanese

  [Refereed]

  Scientific journal


• Endoscopic submucosal dissection using the Flush knife and the Flush knife BT

  Takashi Toyonaga, Mariko Man-i, Tsuyoshi Fujita, James E. East, Dimitri Coumaros, Yoshinori Morita, Masaru Yoshida, Takanobu Hayakumo, Hideto Inokuchi, Takeshi Azuma

  Jan. 2011, Techniques in Gastrointestinal Endoscopy, 13(1) (1), 84 - 90, English

  [Refereed]

  Scientific journal


• 早期胃がんの内視鏡的診断と治療の実際

  Morita Yoshinori

  (一社)日本消化器がん検診学会, Nov. 2010, 日本消化器がん検診学会雑誌, 48(6) (6), 702 - 702, Japanese

  International conference proceedings


• 大腸癌内視鏡治療穿孔症例に対する腹腔鏡下手術

  Matsumoto Ippei, Hori Yuichi, Morita Yoshinori, Ku Yonson, Kuroda Daisuke

  (一社)日本内視鏡外科学会, Oct. 2010, 日本内視鏡外科学会雑誌, 15(7) (7), 617 - 617, Japanese

  International conference proceedings


• The performance of a novel ball-tipped Flush knife for endoscopic submucosal dissection: a case-control study

  T. Toyonaga, M. Man-I, T. Fujita, E. Nishino, W. Ono, Y. Morita, T. Sanuki, A. Masuda, M. Yoshida, H. Kutsumi, H. Inokuchi, T. Azuma

  Oct. 2010, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 32(7) (7), 908 - 915, English

  Scientific journal


• 当院での食道表在癌の内科的及び外科的治療の検討

  Nishimura Hideki, Morita Yoshinori, Kuroda Daisuke, Azuma Takeshi

  (一財)日本消化器病学会, Sep. 2010, 日本消化器病学会雑誌, 107(臨増大会) (臨増大会), A770 - A770, Japanese

  International conference proceedings


• 十二指腸乳頭括約筋機能不全(SOD)に対しEST後再燃した一例

  Shiomi Hideyuki, Morita Yoshinori, Yoshida Masaru, Fujita Tsuyoshi, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2010, Gastroenterological Endoscopy, 52(Suppl.2) (Suppl.2), 2538 - 2538, Japanese

  International conference proceedings


• Retrospective study of technical aspects and complications of endoscopic submucosal dissection for laterally spreading tumors of the colorectum

  T. Toyonaga, M. Man-I, T. Fujita, J. E. East, E. Nishino, W. Ono, Y. Morita, T. Sanuki, M. Yoshida, H. Kutsumi, H. Inokuchi, T. Azuma

  Sep. 2010, ENDOSCOPY, 42(9) (9), 714 - 722, English

  Scientific journal


• NOTES 安全な臨床応用に向けての取り組み Double scopeを用いたHybrid-NOTES手技の開発

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2010, Gastroenterological Endoscopy, 52(Suppl.2) (Suppl.2), 2241 - 2241, Japanese

  International conference proceedings


• ESDにおける手技の工夫 中下咽頭・食道《ビデオ》 当院における食道ESDのstrategyの工夫

  Morita Yoshinori

  (一社)日本消化器内視鏡学会, Sep. 2010, Gastroenterological Endoscopy, 52(Suppl.2) (Suppl.2), 2335 - 2335, Japanese

  International conference proceedings


• EMR、ESDの課題 安全確実な内視鏡医療の提供に向けて 当院におけるESDの安全確実な普及に向けての取り組み

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2010, Gastroenterological Endoscopy, 52(Suppl.2) (Suppl.2), 2253 - 2253, Japanese

  International conference proceedings


• Association between adherence to evidence-based guidelines for the prescription of non-steroidal anti-inflammatory drugs and the incidence of gastric mucosal lesions in Japanese patients.

  Hidetaka Tsumura, Tsuyoshi Fujita, Isamu Tamura, Yoshinori Morita, Masaru Yoshida, Takashi Toyonaga, Hidekazu Mukai, Hideto Inokuchi, Hiromu Kutsumi, Takeshi Azuma

  OBJECTIVE: Recently, guidelines for the treatment and prevention of ulcers induced by non-steroidal anti-inflammatory drugs (NSAIDs) were established. This study investigated the association between the current adherence to the guidelines and the incidence of gastric mucosal lesions caused by NSAIDs. METHODS: This study included 254 NSAIDs users (128 regular and 126 on-demand users) who had undergone upper gastrointestinal endoscopy. The patients were characterized as high risk based on the following: age 65 years or older, history of peptic ulcers, concurrent use of corticosteroids or anticoagulants, and high-dose NSAIDs use. Adherence was defined as the prescription of NSAIDs with proton pump inhibitors, prostaglandin analogues, or high-dose histamine 2 receptor antagonists in high-risk NSAIDs user. The severity of gastric mucosal lesions was evaluated using the modified LANZA score (MLS). RESULTS: Seventy-nine (61.7%) of the regular NSAIDs users and 65 (51.6%) of the on-demand NSAIDs users met our definition of high-risk patients. Adherence in the regular NSAIDs users and on-demand NSAIDs users was 25 (31.7%) and 16 (24.6%), respectively. The incidence of gastric mucosal lesions (MLS ≧ 1) was significantly higher in the nonadherence group than in the adherence group for both regular NSAIDs users (59.3 vs. 28.0%, P = 0.01) and on-demand NSAIDs users (63.3 vs. 25.0%, P = 0.01). Gastric ulcers in the regular NSAIDs users were more frequently observed in the nonadherence group than in the adherence group (29.6 vs. 4.0%, P < 0.01). CONCLUSION: Nonadherence was associated with a high prevalence of NSAIDs-induced gastric mucosal lesions.

  Sep. 2010, Journal of gastroenterology, 45(9) (9), 944 - 51, English, Domestic magazine

  [Refereed]

  Scientific journal


• 炭酸ガスレーザーを用いた胃癌に対する内視鏡的粘膜下層剥離術の検討

  渡辺聡, 山田啓一郎, 石井克典, 間久直, 小畑大輔, 森田圭紀, 東健, 粟津邦男

  Aug. 2010, レーザー学会第402回研究会報告, Japanese

  Research society


• Endoscopic retrieval method using a small grip-seal plastic bag for large colorectal resection specimens after endoscopic submucosal dissection

  S. Tanaka, T. Toyonaga, J. East, D. Obata, S. Fujiwara, C. Wakahara, A. Masuda, M. Man-i, Y. Morita, T. Sanuki, T. Fujita, M. Yoshida, H. Kutsumi, T. Azuma

  Jul. 2010, ENDOSCOPY, 42, E186 - E187, English

  Scientific journal


• Retrospective multicenter study concerning electrocautery forceps with soft coagulation for nonmalignant gastroduodenal ulcer bleeding in Japan.

  Mitsuhiro Fujishiro, Nobutsugu Abe, Masaki Endo, Yoshiro Kawahara, Ryo Shimoda, Shinji Nagata, Kiyoaki Homma, Yoshinori Morita, Noriya Uedo

  Electrocautery forceps with soft coagulation are actively used for treatment of bleeding and nonbleeding visible vessels during endoscopic submucosal dissection, but the usefulness of gastroduodenal ulcer bleeding has not been elucidated so far. The purpose of this paper is to elucidate the outcomes of electrocautery forceps with soft coagulation for peptic and artificial gastroduodenal ulcer bleeding. A retrospective multicenter study of consecutive case series during one year involved nine departments of high-volume hospitals in Japan. The study included 128 consecutive patients (62 with peptic ulcers and 66 with artificial ulcers) with bleeding nonmalignant gastroduodenal ulcers that were revealed using emergency endoscopy between January 2008 and December 2008. Hemostasis was carried out using electrocautery forceps with soft coagulation. Rates of successful initial hemostasis, rebleeding, transfer to surgery, and death according to peptic and artificial ulcer bleeding were recorded. Successful initial endoscopic hemostasis was obtained in 61 peptic ulcer patients (98.4%) and 66 artificial ulcer patients (100%). Rebleeding was observed in seven peptic ulcer patients (11.5%) and five artificial ulcer patients (7.6%). Rates of successful management with endoscopic methods alone were 96.8% (60/62) and 100% (66/66) in peptic ulcer patients and artificial ulcer patients, respectively. There were no severe complications or deaths related to the management of gastroduodenal ulcer bleeding. The novel endoscopic method using electrocautery forceps with soft coagulation for gastroduodenal ulcer bleeding seems to provide safety and efficacy that is comparable with that of endoscopic hemostasis with other established hemostatic techniques.

  Jul. 2010, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 22 Suppl 1, S15-8, English, International magazine

  [Refereed]

  Scientific journal


• Current managements and outcomes of peptic and artificial ulcer bleeding in Japan.

  Mitsuhiro Fujishiro, Nobutsugu Abe, Masaki Endo, Yoshiro Kawahara, Ryo Shimoda, Shinji Nagata, Kiyoaki Homma, Yoshinori Morita, Noriya Uedo

  The recent trend of gastroduodenal ulcer bleeding in Japan has not been elucidated in detail and the data for a new categorized type, artificial ulcer bleeding, is completely lacking. The purpose of this paper is to elucidate current managements and outcomes of peptic and artificial ulcer bleeding in Japan. A retrospective multicenter study of consecutive case series was carried out during one year at nine departments of high-volume hospitals in Japan. The study included 325 consecutive patients (239 with peptic ulcers and 86 with artificial ulcers) with bleeding nonmalignant gastroduodenal ulcers that were revealed by emergency endoscopy between January 2008 and December 2008. Hemostasis was carried out mainly using endoscopic treatments. Rates of successful initial hemostasis, rebleeding, transfer to surgery, and death were recorded according to peptic and artificial ulcer bleeding. Additionally, preferred endoscopic methods, concomitant use of antisecretory drugs, and timing of second-look endoscopy were also measured. A total of 227 (99.1%) of 229 peptic ulcer patients with endoscopic treatment and all (100%) 84 artificial ulcer patients underwent successful tentative hemostasis. Rebleeding occurred in 23 peptic ulcer patients (10.1%) and 10 artificial ulcer patients (11.9%). One peptic ulcer patient and two artificial ulcer patients had final surgical rescue due to rebleeding. No death was observed. Monotherapy was predominant (around 65% of cases) in both types of ulcers. The coagulation forceps method was more frequently applied in artificial ulcers (P < 0.05). A per oral proton pump inhibitor was more frequently used in artificial ulcers (P < 0.05), although an intravenous proton pump inhibitor was used in the majority of patients in both types of ulcers. The frequency of second-look endoscopy in peptic ulcers (88%) was significantly higher than that in artificial ulcers (71%) (P < 0.05). There seemed to be no rule as to the timing of second-look endoscopy, although it was most frequently performed on the day after hemostasis. The recent outcomes of endoscopic treatment for nonmalignant gastroduodenal bleeding in Japan were excellent in both peptic and artificial ulcers with similar efficacies. Although they were minor findings, some differences in applied endoscopic methods, concomitant use of antisecretory drugs, and presence of second-look endoscopy were observed.

  Jul. 2010, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 22 Suppl 1, S9-14, English, International magazine

  [Refereed]

  Scientific journal


• Endoluminal MR imaging of porcine gastric structure in vivo.

  Hayato Yoshinaka, Yoshinori Morita, Yuichiro Matsuoka, Daisuke Obata, Shoko Fujiwara, Ryo Chinzei, Maki Sugimoto, Tsuyoshi Sanuki, Masaru Yoshida, Hideto Inokuchi, Etsuko Kumamoto, Kagayaki Kuroda, Takeshi Azuma, Hiromu Kutsumi

  BACKGROUND AND AIMS: Recently, several new endoscopic instruments have been developed. However, even with the full use of current modalities, the safety of endoscopic surgery is not guaranteed. Information regarding factors such as fibrosis and the blood vessels under the mucosa is very important for avoiding procedure-related complications. The aim of this study was to define the detailed anatomy of the gastric wall structure in vivo using original endoluminal radiofrequency coils for safer endoscopic therapy. METHODS: Swine were used as the subjects and controlled with general anesthesia. Anatomical images were obtained with T1-weighted fast spin echo (T1FSE) and T2-weighted fast spin echo (T2FSE). Dynamic magnetic resonance (MR) angiography was also obtained with three-dimensional T1-weighted fast spoiled gradient recalled acquisition in the steady state (3D-DMRA) following the injection of hyaluronic acid sodium into the submucosal layer. RESULTS: Porcine gastric wall structure was visualized, and four layers were discriminated in the T1FSE and T2FSE images. The vascular structure was clearly recognized in the submucosa on 3D-DMRA. CONCLUSION: Endoluminal MR imaging was able to visualize the porcine stomach with similar quality to endoscopic ultrasonography imaging. Additionally, it was possible to visualize the vascular structures in the submucosal layer. This is the first report to show that blood vessels under the gastric mucosa can be depicted in vivo.

  Jun. 2010, Journal of gastroenterology, 45(6) (6), 600 - 7, English, Domestic magazine

  [Refereed]

  Scientific journal


• Vitamin K-3 attenuates lipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-kappa B activation

  S. Tanaka, S. Nishiumi, M. Nishida, Y. Mizushina, K. Kobayashi, A. Masuda, T. Fujita, Y. Morita, S. Mizuno, H. Kutsumi, T. Azuma, M. Yoshida

  May 2010, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 160(2) (2), 283 - 292, English

  [Refereed]

  Scientific journal


• Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-kappaB activation.

  Masayuki Nishida, Shin Nishiumi, Yoshiyuki Mizushina, Yoshimi Fujishima, Koji Yamamoto, Atsuhiro Masuda, Shigeto Mizuno, Tsuyoshi Fujita, Yoshinori Morita, Hiromu Kutsumi, Hiromi Yoshida, Takeshi Azuma, Masaru Yoshida

  Curcumin, a component of turmeric (Curcuma longa), is known to exert a variety of biological functions including anti-inflammatory activity. We examined the inhibitory effects of chemically synthesized derivatives of curcumin against inflammatory responses and compared them with those of curcumin, in order to find derivatives with stronger effects than curcumin. In a cell culture system using the mouse macrophage cell line RAW264.7, monoacetylcurcumin strongly inhibited IkappaB phosphorylation, nuclear factor (NF)-kappaB activation and tumor necrosis factor (TNF)-alpha production induced by lipopolysaccharide (LPS). In addition, oral administration of monoacetylcurcumin to mice led to greater suppression of TNF-alpha production after LPS stimulation than the administration of curcumin or tetrahydrocurcumin in vivo. Monoacetylcurcumin also inhibited the LPS-induced NF-kappaB activation in the liver. Collectively, monoacetylcurcumin is a potential chemopreventive agent for treating inflammatory responses more effectively than curcumin.

  May 2010, International journal of molecular medicine, 25(5) (5), 761 - 7, English, International magazine

  [Refereed]

  Scientific journal


• ワイヤー型冠動脈圧モニターを用いた十二指腸乳頭括約筋圧測定の試み

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2010, Gastroenterological Endoscopy, 52(Suppl.1) (Suppl.1), 1071 - 1071, Japanese

  International conference proceedings


• 分枝優位型IPMNの手術適応決定のための診断アルゴリズムの確立

  Shiomi Hideyuki, Morita Yoshinori, Yoshida Masaru, Fujita Tsuyoshi, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2010, Gastroenterological Endoscopy, 52(Suppl.1) (Suppl.1), 1077 - 1077, Japanese

  International conference proceedings


• 播種状黄色腫による食道狭窄に対して内視鏡的バルーン拡張術が有効であった1例

  Morita Yoshinori, Shiomi Hideyuki, Yoshida Masaru, Fujita Tsuyoshi, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2010, Gastroenterological Endoscopy, 52(Suppl.1) (Suppl.1), 992 - 992, Japanese

  International conference proceedings


• 超高齢者早期胃癌に対するESD適応の検討

  Morita Yoshinori

  (一社)日本消化器内視鏡学会, Apr. 2010, Gastroenterological Endoscopy, 52(Suppl.1) (Suppl.1), 1001 - 1001, Japanese

  International conference proceedings


• 食道・胃腫瘍に対するImage-enhanced endoscopy(IEE)の臨床的意義 食道表在癌の深達度診断におけるNBI併用拡大内視鏡観察

  Morita Yoshinori

  (一社)日本消化器内視鏡学会, Apr. 2010, Gastroenterological Endoscopy, 52(Suppl.1) (Suppl.1), 810 - 810, Japanese

  International conference proceedings


• 食道・胃・大腸ESD 早期胃癌に対する安全確実なESDを目指して スプリットバレルによるDouble scope-ESD

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2010, Gastroenterological Endoscopy, 52(Suppl.1) (Suppl.1), 843 - 843, Japanese

  International conference proceedings


• 消化器内視鏡教育のあり方 当院における高度消化器内視鏡治療(特にESD)普及に向けての取り組み

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2010, Gastroenterological Endoscopy, 52(Suppl.1) (Suppl.1), 849 - 849, Japanese

  International conference proceedings


• 下部消化管ESDの手技と工夫 大腸腫瘍に対する内視鏡治療の簡素化について

  Morita Yoshinori

  (一社)日本消化器内視鏡学会, Apr. 2010, Gastroenterological Endoscopy, 52(Suppl.1) (Suppl.1), 831 - 831, Japanese

  International conference proceedings


• 咽頭・食道微小病変の診断と取扱い 中・下咽頭微小病変に対するNBI併用拡大観察を用いた診断能の検討

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2010, Gastroenterological Endoscopy, 52(Suppl.1) (Suppl.1), 858 - 858, Japanese

  International conference proceedings


• 安全なESD鎮静の為に NLA変法でのカプノメータによるモニタリングとアルコール多飲症例でのデクスメデトミジンによる鎮静

  Morita Yoshinori

  (一社)日本消化器内視鏡学会, Apr. 2010, Gastroenterological Endoscopy, 52(Suppl.1) (Suppl.1), 988 - 988, Japanese

  International conference proceedings


• RebamipideによるESD後潰瘍の治癒促進効果

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2010, Gastroenterological Endoscopy, 52(Suppl.1) (Suppl.1), 997 - 997, Japanese

  International conference proceedings


• 非ステロイド抗炎症薬による胃粘膜障害予防に対するガイドライン遵守の現況

  Fujita Tsuyoshi, Morita Yoshinori, Yoshida Masaru, Azuma Takeshi

  (一財)日本消化器病学会, Mar. 2010, 日本消化器病学会雑誌, 107(臨増総会) (臨増総会), A301 - A301, Japanese

  International conference proceedings


• 内視鏡スタッフの教育について 内視鏡技師が技術提供するESDハンズオントレーニング 内視鏡医と内視鏡技師の双方が成長するための教育環境

  Morita Yoshinori

  (一社)日本消化器内視鏡技師会, Mar. 2010, 日本消化器内視鏡技師会会報, 巻, 44号, pp. 51-53(44) (44), 51 - 53, Japanese

  International conference proceedings


• 早期胃癌に対する内視鏡的粘膜下層剥離術ESD、経管腔的内視鏡手術NOTESと単孔式腹腔鏡下手術の標準化とGPS navigationの開発

  Morita Yoshinori, Azuma Takeshi

  (一社)日本外科学会, Mar. 2010, 日本外科学会雑誌, 111(臨増2) (臨増2), 339 - 339, Japanese


• Selective mucosal ablation using CO2 laser for the development of novel endoscopic submucosal dissection: Comparison of continuous wave and nanosecond pulsed wave

  K. Ishii, S. Watanabe, D. Obata, H. Hazama, Y. Morita, Y. Matsuoka, H. Kutsumi, T. Azuma, K. Awazu

  2010, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7562

  [Refereed]

  International conference proceedings


• 炭酸ガスレーザーと光吸収剤を用いた選択的粘膜下層剥離

  石井 克典, 渡辺 聡, 小畑 大輔, 間 久直, 森田 圭紀, 松岡 雄一郎, 久津見 弘, 東 健, 粟津 邦男

  (NPO)日本レーザー医学会, Jan. 2010, 日本レーザー医学会誌, 30(4) (4), 471 - 471, Japanese


• Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis.

  Tsukasa Ishida, Masaru Yoshida, Makoto Arita, Yosuke Nishitani, Shin Nishiumi, Atsuhiro Masuda, Shigeto Mizuno, Tetsuya Takagawa, Yoshinori Morita, Hiromu Kutsumi, Hideto Inokuchi, Charles N Serhan, Richard S Blumberg, Takeshi Azuma

  BACKGROUND: Resolvin E1 (RvE1), an endogenous lipid mediator derived from eicosapentaenoic acid, has been identified in local inflammation during the healing stage. RvE1 reduces inflammation in several types of animal models including peritonitis and retinopathy and blocks human neutrophil transendothelial cell migration. The RvE1 receptor ChemR23 is expressed on myeloid cells such as macrophages and dendritic cells. The aim of this study was to determine whether RvE1 regulates colonic inflammation when the innate immune response of macrophages plays a key role in pathogenesis and tissue damage. METHODS: The RvE1 receptor ChemR23 was expressed in mouse peritoneal macrophages as defined by flow cytometry. Peritoneal macrophages were pretreated with RvE1, followed by lipopolysaccharide stimulation, whereupon transcriptional levels of proinflammatory cytokines were analyzed. RESULTS: RvE1 treatment led to inhibition of proinflammatory cytokines including TNF-alpha and IL-12p40. In HEK293 cells, pretreatment with RvE1 inhibited TNF-alpha-induced nuclear translocation of NF-kappaB in a ChemR23-dependent manner. These results suggested that RvE1 could regulate proinflammatory responses of macrophages expressing ChemR23. Therefore, we investigated the beneficial effects of RvE1 in dextran sulfate sodium-induced colitis. RvE1 treatment led to amelioration of colonic inflammation. CONCLUSIONS: These results indicate that RvE1 suppresses proinflammatory responses of macrophages. RvE1 and its receptor may therefore be useful as therapeutic targets in the treatment of human inflammatory bowel disease and other inflammatory disorders.

  Jan. 2010, Inflammatory bowel diseases, 16(1) (1), 87 - 95, English, International magazine

  [Refereed]

  Scientific journal


• Low-dose aspirin-induced gastroduodenal mucosal injury in Japanese patients with arteriosclerotic disease.

  Isamu Tamura, Tsuyoshi Fujita, Hidetaka Tsumura, Yoshinori Morita, Masaru Yoshida, Takashi Toyonaga, Seiichi Hirano, Hideto Inokuchi, Hiromu Kutsumi, Takeshi Azuma

  BACKGROUND: We aimed to elucidate the risk factors and preventive factors associated with chronic low-dose aspirin (L-ASA)-induced gastroduodenal mucosal injury in Japanese patients with arteriosclerotic disease. METHODS: This retrospective observational study included 400 L-ASA users who underwent upper gastrointestinal endoscopy. We investigated patients' clinical characteristics, including age, peptic ulcer history, concomitant drugs [i.e. gastric agents, antiplatelet drugs, anticoagulants, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids], abdominal symptoms, endoscopic findings, and interruption of L-ASA before endoscopy. The severity of gastroduodenal mucosal lesions was evaluated using the modified LANZA score (MLS). RESULTS: Of 400 patients, 249 (62%) and 41 (10%) had gastroduodenal mucosal lesions (MLS ≥1) and gastroduodenal ulcers, respectively. Peptic ulcer history, abdominal symptoms, proton pump inhibitor (PPI), histamine type 2-receptor antagonists (H2RA), and the cessation of L-ASA before endoscopy were significantly associated with L-ASA-induced gastroduodenal ulcers; the odds ratio (OR) (confidence interval (CI)) was 5.49 (1.82-16.55), 4.56 (1.93-10.75), 0.12 (0.03-0.42), 0.13 (0.04-0.40) and 0.11 (0.04-0.29), respectively. Moreover, patients having two or more of five factors [i.e. advanced age (≥75), anticoagulants, antiplatelet drugs, NSAIDs and corticosteroids] had a significantly higher prevalence of L-ASA-induced gastroduodenal ulcers [OR (CI): 2.39 (1.002-5.69)]. CONCLUSION: Peptic ulcer history, abdominal symptoms and the summation of risk factors increased the risk for L-ASA-induced gastroduodenal ulcers. H2RAs and PPIs were effective for the prevention of L-ASA-induced gastroduodenal ulcers. The cessation of L-ASA before endoscopy might lead to the underestimation of L-ASA-induced gastroduodenal injury.

  2010, Internal medicine (Tokyo, Japan), 49(23) (23), 2537 - 45, English, Domestic magazine

  [Refereed]

  Scientific journal


• Endoscopic treatment for early stage colorectal tumors: the comparison between EMR with small incision, simplified ESD, and ESD using the standard flush knife and the ball tipped flush knife

  Toyonaga Takashi, Morita Yoshinori, Yoshida Masaru, Fujita Tsuyoshi, Azuma Takeshi

  2010, Acta chirurgica Iugoslavica, Vol. 57, No. 3, pp. 41-6, English

  Scientific journal


• 内視鏡の読み方 ESDにより確定診断しえた食道海綿状血管腫の1例(解説/症例報告)

  万井 真理子, 豊永 高史, 森田 圭紀, 横崎 宏, 東 健

  (株)日本メディカルセンター, Dec. 2009, 臨床消化器内科, 25(1) (1), 139 - 144, Japanese


• 鏡視下肝切除・NOTESを支援するGPS navigationの開発

  Morita Yoshinori, Azuma Takeshi

  (一社)日本内視鏡外科学会, Dec. 2009, 日本内視鏡外科学会雑誌, 14(7) (7), 558 - 558, Japanese

  International conference proceedings


• NOTES Single incision NOTESによる内視鏡的胃全層切除縫合術・胆嚢摘出術

  Morita Yoshinori, Azuma Takeshi

  (一社)日本内視鏡外科学会, Dec. 2009, 日本内視鏡外科学会雑誌, 14(7) (7), 211 - 211, Japanese

  International conference proceedings


• ̓内視鏡の読み方 粘膜下腫瘍様の形態を呈した手術既往のないgastritis cystica profundaの1例

  吉江 智郎, 豊永 高史, 小畑 大輔, 吉田 志栄, 森田 圭紀, 横崎 宏, 東 健

  (株)日本メディカルセンター, Oct. 2009, 臨床消化器内科, 24(12) (12), 1633 - 1637, Japanese


• 当院におけるERCP後膵炎の現状と対策

  Morita Yoshinori, Seo Yasushi, Toyonaga Takashi, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2009, 日本消化器病学会雑誌, 51(Suppl.2) (Suppl.2), 2284 - 2284, Japanese

  International conference proceedings


• 表在型食道癌に対する内視鏡的治療の適応拡大と治療戦略

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2009, Gastroenterological Endoscopy, 51(Suppl.2) (Suppl.2), 2176 - 2176, Japanese

  International conference proceedings


• 内視鏡技師が技術提供するESDハンズオンセミナー 内視鏡医と内視鏡技師の双方が成長するための教育環境

  Morita Yoshinori

  (一社)日本消化器内視鏡学会, Sep. 2009, Gastroenterological Endoscopy, 51(Suppl.2) (Suppl.2), 2345 - 2345, Japanese

  International conference proceedings


• 中・下咽頭表在癌の診断と治療の最先端 中・下咽頭微小病変に対するNBI併用拡大観察を用いた診断能の検討

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2009, Gastroenterological Endoscopy, 51(Suppl.2) (Suppl.2), 2068 - 2068, Japanese

  International conference proceedings


• 大腸ESDにおける偶発症とその対応 術中CO2送気の有用性について

  Morita Yoshinori

  (一社)日本消化器内視鏡学会, Sep. 2009, Gastroenterological Endoscopy, 51(Suppl.2) (Suppl.2), 2306 - 2306, Japanese

  International conference proceedings


• 消化管内視鏡における安全・危機管理の実際 上部消化管ESDにおける術中モニタリングの有用性の検討 安全な鎮静・鎮痛管理を目指して

  Morita Yoshinori

  (一社)日本消化器内視鏡学会, Sep. 2009, Gastroenterological Endoscopy, 51(Suppl.2) (Suppl.2), 2132 - 2132, Japanese

  International conference proceedings


• 胃ESDにおける困難例に対する対応 早期胃癌に対するESD治療困難症例の克服 スプリットバレルによるDouble scope-ESD

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2009, Gastroenterological Endoscopy, 51(Suppl.2) (Suppl.2), 2140 - 2140, Japanese

  International conference proceedings


• RebamipideによるESD後潰瘍の治癒促進効果 拡大観察による評価も含めて

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2009, Gastroenterological Endoscopy, 51(Suppl.2) (Suppl.2), 2325 - 2325, Japanese

  International conference proceedings


• NOTES関連の新しい内視鏡治療 日米におけるNOTES経管腔的内視鏡手術トレーニングとナビゲーションシステム開発

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2009, Gastroenterological Endoscopy, 51(Suppl.2) (Suppl.2), 2122 - 2122, Japanese

  International conference proceedings


• NOTES関連の新しい内視鏡治療 Double scopeを用いたNOTES手技による胃空腸吻合術の開発

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2009, Gastroenterological Endoscopy, 51(Suppl.2) (Suppl.2), 2121 - 2121, Japanese

  International conference proceedings


• 【消化器診療 示唆に富む症例】 胃粘膜下腫瘍様の形態を呈した1例

  吉江 智郎, 吉田 志栄, 小畑 大輔, 森田 圭紀, 豊永 高史, 横崎 宏, 東 健

  (株)ヴァンメディカル, Aug. 2009, 消化器の臨床, 12(4) (4), 360 - 363, Japanese


• 安全確実な腹腔鏡下胆嚢摘出術の工夫 腹腔鏡下胆道手術における術中ルシフェリン蛍光胆道造影とICG蛍光胆道造影の有効性

  Morita Yoshinori, Azuma Takeshi

  日本胆道学会, Aug. 2009, 胆道, 23(3) (3), 440 - 440, Japanese


• The new resources of treatment for early stage colorectal tumors: EMR with small incision and simplified endoscopic submucosal dissection.

  Takashi Toyonaga, Mariko Man-I, Yoshinori Morita, Tsuyoshi Sanuki, Masaru Yoshida, Hiromu Kutsumi, Hideto Inokuchi, Takeshi Azuma

  INTRODUCTION: Early stage colorectal tumors can be removed by endoscopic mucosal resection (EMR) but larger tumors (> or =20 mm) may require piecemeal resection. The development of endoscopic submucosal dissection (ESD) has enabled en-bloc resection of lesions regardless of size and shape. However ESD of colorectal tumor is technically difficult. As the resources, we perform EMR with small incision (EMR with SI) for more reliable EMR, and also ESD with snaring (simplified ESD) for easier and safer ESD. AIM & METHODS: The aim of the study was to retrospectively compare the treatment results of the following 3 methods (EMR with SI/ simplified ESD/ ESD). We treated 24/44/468 colorectal tumors, and examined the tumor size, resected specimen size, procedure time, en-bloc resection rate, complication rate. RESULT: The median tumor size (mm) (EMR with SI/simplified EMR/ESD) was 20/17/30 (EMR with SI vs simplified ESD: P = n.s, simplified ESD vs ESD: P < 0.0001). The median resected specimen size (mm) was 22.5/26/41 (EMR with SI vs simplified ESD: P = 0.0018, simplified ESD vs ESD: P < 0.0001). The procedure time (min.) was 19/27/60 (EMR with SI vs simplified ESD: P = n.s, simplified ESD vs ESD: P < 0.0001) The en-bloc resection rate (%) was 83.3/90.9/98.9. The complication rate (post-operative bleeding rate/perforation rate) was 0/0, 2.3/4.5, 1.5/1.5 (simplified ESD vs ESD: P = n.s). CONCLUSION: Endoscopic mucosal resection with small incision (EMR with SI) and ESD with snaring (simplified ESD) are a good option to fill the differences between conventional EMR and ESD, and also considered to become nice steps to the introduction of ESD.

  Jul. 2009, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 21 Suppl 1, S31-7, English, International magazine

  [Refereed]

  Scientific journal


• EMR/ESD How I do it 食道表在癌に対するESDの工夫 Flushナイフを用いて

  Morita Yoshinori, Azuma Takeshi

  (NPO)日本食道学会, Jun. 2009, 日本食道学会学術集会プログラム・抄録集63回, 63回, 123 - 123, Japanese

  International conference proceedings


• 当院における大腸ESDの治療成績

  Morita Yoshinori, Azuma Takeshi

  (社)日本大腸検査学会, May 2009, 日本大腸検査学会雑誌, 26(1) (1), 72 - 72, Japanese

  International conference proceedings


• 炭酸ガスレーザーを用いた選択的粘膜下層剥離に関する基礎的検討

  渡辺 聡, 石井 克典, 小畑 大輔, 間 久直, 森田 佳紀, 久津見 弘, 東 健, 粟津 邦男

  (NPO)日本医工学治療学会, Apr. 2009, 医工学治療, 21(Suppl.) (Suppl.), 99 - 99, Japanese

  Research society


• 胆管深部挿管困難例に対する膵管ステント併用プレカットの有用性、安全性に関する検討

  Morita Yoshinori, Seo Yasushi, Toyonaga Takashi, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2009, 日本消化器病学会雑誌, 51(Suppl.1) (Suppl.1), 954 - 954, Japanese

  International conference proceedings


• Newly Developed Surface Coil for Endoluminal MRI, Depiction of Pig Gastric Wall Layers and Vascular Architecture in Ex Vivo Study

  Yoshinori Morita, Hiromu Kutsumi, Yuichiro Matsuoka, Hayato Yoshinaka, Masaru Yoshida, Hideto Inokuchi, Takeshi Azuma

  Apr. 2009, GASTROINTESTINAL ENDOSCOPY, 69(5) (5), AB369 - AB369, English

  Scientific journal


• 表在型食道癌ESD術後狭窄に対する内視鏡的拡張術の有用性

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2009, Gastroenterological Endoscopy, 51(Suppl.1) (Suppl.1), 896 - 896, Japanese

  International conference proceedings


• 大腸腫瘍に対するESDの標準化 適応 当院における大腸ESDの現状

  Morita Yoshinori

  (一社)日本消化器内視鏡学会, Apr. 2009, Gastroenterological Endoscopy, 51(Suppl.1) (Suppl.1), 712 - 712, Japanese

  International conference proceedings


• 高齢者早期胃癌に対するESD適応についての検討

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2009, Gastroenterological Endoscopy, 51(Suppl.1) (Suppl.1), 872 - 872, Japanese

  International conference proceedings


• チーム医療の中での内視鏡技師の役割 当院が誇るチームESDにおけるPersonnel organization

  Morita Yoshinori

  (一社)日本消化器内視鏡学会, Apr. 2009, Gastroenterological Endoscopy, 51(Suppl.1) (Suppl.1), 987 - 987, Japanese

  International conference proceedings


• ESDの手技の工夫 大腸癌 大腸ESDにおけるFlushナイフの有用性

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2009, Gastroenterological Endoscopy, 51(Suppl.1) (Suppl.1), 795 - 795, Japanese

  International conference proceedings


• ESDの手技の工夫 食道癌 食道表在癌に対するESDの工夫 Flushナイフを用いて

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2009, Gastroenterological Endoscopy, 51(Suppl.1) (Suppl.1), 783 - 783, Japanese

  International conference proceedings


• 早期胃癌に対するESD施行後の人工潰瘍に対するRebamipideの有用性の検討

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (一財)日本消化器病学会, Mar. 2009, 日本消化器病学会雑誌, 106(臨増総会) (臨増総会), A293 - A293, Japanese

  International conference proceedings


• 当院でのESD普及に向けての取り組み

  Morita Yoshinori, Azuma Takeshi

  (一社)日本胃癌学会, Mar. 2009, 日本胃癌学会総会記事81回, 81回, 358 - 358, Japanese

  International conference proceedings


• Newly developed surface coil for endoluminal MRI, depiction of pig gastric wall layers and vascular architecture in ex vivo study.

  Yoshinori Morita, Hiromu Kutsumi, Hayato Yoshinaka, Yuichiro Matsuoka, Kagayaki Kuroda, Masakazu Gotanda, Naomi Sekino, Etsuko Kumamoto, Masaru Yoshida, Hideto Inokuchi, Takeshi Azuma

  BACKGROUND: The purpose of this study was to visualize the gastric wall layers and to depict the vascular architecture in vitro by using resected porcine stomachs studied with high-spatial resolution magnetic resonance (MR) imaging. METHODS: Normal dissected porcine stomach samples (n = 4) were examined with a 3 Tesla MR system using a newly developed surface coil. MR images were obtained by the surface coil as receiver and a head coil as transmitter. High-spatial-resolution spin-echo MR images were obtained with a field of view of 8 x 8 cm, a matrix of 256 x 128 and slice thicknesses of 3 and 5 mm. RESULTS: T1 and T2-weighted MR images clearly depicted the normal porcine gastric walls as consisting of four distinct layers. In addition, vascular architectures in proper muscle layers were also visualized, which were confirmed by histological examinations to correspond to blood vessels. CONCLUSIONS: High-spatial-resolution MR imaging using a surface coil placed closely to the gastric wall enabled the differentiation of porcine gastric wall layers and the depiction of the blood vessels in proper muscle layer in this experimental study.

  2009, Journal of gastroenterology, 44(5) (5), 390 - 5, English, Domestic magazine

  [Refereed]

  Scientific journal


• 患者を"み"ることができる内視鏡技師 臨床工学の視点からみたENDO Therapy 内視鏡治療時における生体とESUの関係

  Morita Yoshinori

  (一社)日本消化器内視鏡学会, 2009, Gastroenterological Endoscopy, 51(Supplement 1) (Supplement 1), 985 - 985, Japanese


• 当院で経験した膵管内乳頭粘液性腫瘍(IPMN)の他臓器癌の合併についての検討

  Morita Yoshinori, Seo Yasushi, Toyonaga Takashi, Ku Yonson, Azuma Takeshi

  (一財)日本消化器病学会, Sep. 2008, 日本消化器病学会雑誌, 105(臨増大会) (臨増大会), A899 - A899, Japanese

  International conference proceedings


• 内視鏡の偶発症対策 術前・術中・術後 上部消化管ESDにおけるより安全な鎮静・鎮痛管理のために 術中モニタリングの有用性の検討

  Toyonaga Takashi, Morita Yoshinori

  (一社)日本消化器内視鏡学会, Sep. 2008, Gastroenterological Endoscopy, 50(Suppl.2) (Suppl.2), 2072 - 2072, Japanese

  International conference proceedings


• 当院における食道表在癌の内視鏡的治療について

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2008, Gastroenterological Endoscopy, 50(Suppl.2) (Suppl.2), 2254 - 2254, Japanese

  International conference proceedings


• 通常スコープと細径スコープの臨床使用 早期胃癌に対するESD治療困難症例の克服 細径スコープを用いた「スプリットバレルによるDouble scope-ESD」

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2008, Gastroenterological Endoscopy, 50(Suppl.2) (Suppl.2), 2148 - 2148, Japanese

  International conference proceedings


• 大腸腫瘍の内視鏡的治療の選択と問題点 大腸ESDの現状と問題点

  Morita Yoshinori, Toyonaga Takashi

  (一社)日本消化器内視鏡学会, Sep. 2008, Gastroenterological Endoscopy, 50(Suppl.2) (Suppl.2), 2122 - 2122, Japanese

  International conference proceedings


• 早期胃癌に対する側方進展範囲診断の検討

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2008, Gastroenterological Endoscopy, 50(Suppl.2) (Suppl.2), 2266 - 2266, Japanese

  International conference proceedings


• 消化器内視鏡教育の現状と問題点 当院での高度消化器内視鏡治療(特にESD)普及に向けての取り組み

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2008, Gastroenterological Endoscopy, 50(Suppl.2) (Suppl.2), 2100 - 2100, Japanese

  International conference proceedings


• MR内視鏡システムによる新たな内視鏡的治療支援技術の開発

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2008, Gastroenterological Endoscopy, 50(Suppl.2) (Suppl.2), 2265 - 2265, Japanese

  International conference proceedings


• ESD術後狭窄に対する内視鏡的拡張術の有用性

  Morita Yoshinori, Toyonaga Takashi

  (一社)日本消化器内視鏡学会, Sep. 2008, Gastroenterological Endoscopy, 50(Suppl.2) (Suppl.2), 2257 - 2257, Japanese

  International conference proceedings


• ワイヤー型冠動脈圧モニターを用いた十二指腸乳頭括約筋圧測定の試み

  Morita Yoshinori, Yoshida Masaru, Fujita Tsuyoshi, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2008, Gastroenterological Endoscopy, 50(Suppl.2) (Suppl.2), 2356 - 2356, Japanese

  International conference proceedings


• Role of metallothionein in Helicobacter pylori-positive gastric mucosa with or without early gastric cancer and the effect on its expression after eradication therapy.

  Toshifumi Mitani, Daisuke Shirasaka, Nobuo Aoyama, Ikuya Miki, Yoshinori Morita, Nobunao Ikehara, Yuko Matsumoto, Tatsuya Okuno, Masanori Toyoda, Hideyuki Miyachi, Shiei Yoshida, Naoko Chayahara, Junko Hori, Takao Tamura, Takeshi Azuma, Masato Kasuga

  Aug. 2008, Journal of gastroenterology and hepatology, 23(8 Pt 2) (8 Pt 2), e334-9 - E339, English, International magazine

  [Refereed]

  Scientific journal


• 高齢者消化管がんの治療戦略 最適の対応を求めて 高齢者早期胃癌に対するESD適応についての検討

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (NPO)日本高齢消化器病学会, Jul. 2008, 日本高齢消化器病学会誌, 11(1) (1), 53 - 53, Japanese

  International conference proceedings


• Is IIc型病変の1例

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (株)日本メディカルセンター, May 2008, 早期大腸癌, 12(3) (3), 328 - 328, Japanese

  International conference proceedings


• Clinical role of gyra mutations in 7-and 10-day PPI-levofloxacin-amoxicillin regimens for refractory Helicobacter pylori infection to standard therapy

  Ikuya Miki, Hideyuki Miyachi, Yuko Matsumoto, Yoshinori Morita, Masaru Yoshida, Takao Tamura, Takashi Toyonaga, Hiromu Kutsumi, Hideto Inokuchi, Shigeto Mizuno, Takeshi Azuma

  Apr. 2008, GASTROENTEROLOGY, 134(4) (4), A334 - A334, English

  [Refereed]


• 当院で経験した中・下咽頭微小癌の検討

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2008, Gastroenterological Endoscopy, 50(Suppl.1) (Suppl.1), 919 - 919, Japanese

  International conference proceedings


• 早期胃癌適応拡大病変に対するESDの現状と問題点 神戸大学附属病院および岸和田徳州会病院における早期胃癌適応拡大病変に対するESDの治療成績

  Morita Yoshinori, Toyonaga Takashi

  (一社)日本消化器内視鏡学会, Apr. 2008, Gastroenterological Endoscopy, 50(Suppl.1) (Suppl.1), 665 - 665, Japanese

  International conference proceedings


• 食道癌内視鏡治療後の術後狭窄予防に関する検討

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2008, Gastroenterological Endoscopy, 50(Suppl.1) (Suppl.1), 926 - 926, Japanese

  International conference proceedings


• Fcgamma receptor regulation of Citrobacter rodentium infection.

  Atsuhiro Masuda, Masaru Yoshida, Hideyuki Shiomi, Satoshi Ikezawa, Tetsuya Takagawa, Hiroshi Tanaka, Ryo Chinzei, Tsukasa Ishida, Yoshinori Morita, Hiromu Kutsumi, Hideto Inokuchi, Shuo Wang, Kanna Kobayashi, Shigeto Mizuno, Akira Nakamura, Toshiyuki Takai, Richard S Blumberg, Takeshi Azuma

  Apr. 2008, Infection and immunity, 76(4) (4), 1728 - 37, English, International magazine

  Scientific journal


• ESD治療困難例における手技の工夫(上部消化管) 早期胃癌に対するESD治療困難症例の克服 スプリットバレルによるDouble scope-ESD

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2008, Gastroenterological Endoscopy, 50(Suppl.1) (Suppl.1), 758 - 758, Japanese

  International conference proceedings


• 大腸ポリープ切除後のサーベイランスの比較検討

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (一財)日本消化器病学会, Mar. 2008, 日本消化器病学会雑誌, 105(臨増総会) (臨増総会), A246 - A246, Japanese

  International conference proceedings


• 高齢者における消化器疾患の治療 高齢者早期胃癌に対するESD適応についての検討

  Morita Yoshinori, Toyonaga Takashi

  (一財)日本消化器病学会, Mar. 2008, 日本消化器病学会雑誌, 105(臨増総会) (臨増総会), A88 - A88, Japanese

  International conference proceedings


• 早期胃癌に対するESD施行後の人工潰瘍に対するRebamipideの有用性の検討

  Morita Yoshinori, Azuma Takeshi

  (一財)日本消化器病学会, Mar. 2008, 日本消化器病学会雑誌, 105(臨増総会) (臨増総会), A396 - A396, Japanese

  International conference proceedings


• The results and limitations of endoscopic submucosal dissection for colorectal tumors

  Toyonaga Takashi, Morita Yoshinori, Azuma Takeshi

  2008, Acta chirurgica Iugoslavica, Vol. 55, No. 3, pp. 17-23, English

  Scientific journal


• Relationship of BRAF mutation, morphology, and apoptosis in early colorectal cancer.

  Shiei Yoshida, Nobunao Ikehara, Nobuo Aoyama, Daisuke Shirasaka, Masanori Sakashita, Shuho Semba, Tadateru Hasuo, Ikuya Miki, Yoshinori Morita, Takao Tamura, Takeshi Azuma, Hiroshi Yokozaki, Masato Kasuga

  Jan. 2008, International journal of colorectal disease, 23(1) (1), 7 - 13, English, International magazine

  Scientific journal


• Lansoprazoleは早期胃癌の病変視認性を改善させる

  Morita Yoshinori

  (株)メディカルレビュー社, Dec. 2007, The GI Forefront, 3(2) (2), 182 - 182, Japanese


• 当院における大腸腫瘍(特にLST病変)に対する治療戦略

  MORITA YOSHINORI

  (一社)日本消化器内視鏡学会, Sep. 2007, Gastroenterological Endoscopy, 49(Suppl.2) (Suppl.2), 2356 - 2356, Japanese

  International conference proceedings


• ESDの標準化のための手技の工夫 上部消化管 早期胃癌に対するESDの標準化を目指して Double scope-ESDの開発

  Morita Yoshinori

  (一社)日本消化器内視鏡学会, Sep. 2007, Gastroenterological Endoscopy, 49(Suppl.2) (Suppl.2), 2250 - 2250, Japanese

  International conference proceedings


• Is only PPI administration actually effective?; Possible synergistic effect of enterokinetic agent

  Hideyuki Miyachi, Nobuo Aoyama, Daisuke Shirasaka, Ikuya Miki, Masanori Toyoda, Mitani Toshifumi, Yuko Matsumoto, Yoshinori Morita, Takao Tamura, Hiromu Kutsumi, Hideto Inokuchi, Takeshi Azuma, Masato Kasuga

  Apr. 2007, GASTROENTEROLOGY, 132(4) (4), A375 - A375, English

  [Refereed]


• Comparative evaluation of E-test and Agar dilution method for susceptibility testing to detect levofloxacin-resistant Helicobacter pylori isolates with gyrA mutations

  Hideyuki Miyachi, Daisuke Shirasaka, Nobuo Aoyama, Ikuya Miki, Yuko Matsumoto, Toshio Tanaka, Yoshinori Morita, Takao Tamura, Hiromu Kutsumi, Hideto Inokuchi, Takeshi Azuma, Masato Kasuga

  Apr. 2007, GASTROENTEROLOGY, 132(4) (4), A612 - A612, English

  [Refereed]


• 内視鏡医育成教育の現状と将来 当院における内視鏡的粘膜下層剥離術(ESD)普及に向けての取り組み

  MORITA YOSHINORI

  (一社)日本消化器内視鏡学会, Apr. 2007, Gastroenterological Endoscopy, 49(Suppl.1) (Suppl.1), 649 - 649, Japanese

  International conference proceedings


• The relationship between gastric emptying determined by the breath test and H. pylori.

  Shigeyuki Ebara, Daisuke Shirasaka, Nobuo Aoyama, Masaaki Kachi, Ikuya Miki, Yoshinori Morita, Takao Tamura, Masato Kasuga

  Mar. 2007, Hepato-gastroenterology, 54(74) (74), 613 - 6, English, International magazine

  Scientific journal


• 当院における大腸LST病変に対する治療戦略

  Morita Yoshinori

  (一財)日本消化器病学会, Mar. 2007, Gastroenterological Endoscopy, 104(臨増総会) (臨増総会), A32 - A32, Japanese


• No significant difference in neutrophil activation found among three H2RAs

  M. Fukuda, D. Shirasaka, N. Aoyama, I. Miki, M. Kachi, Y. Morita, T. Tamura, M. Kasuga

  Feb. 2007, DIGESTIVE AND LIVER DISEASE, 39(2) (2), 130 - 135, English

  Scientific journal


• Prescription of nonsteroidal anti-inflammatory drugs and co-prescribed drugs for mucosal protection: analysis of the present status based on questionnaires obtained from orthopedists in Japan.

  Hidetaka Tsumura, Isamu Tamura, Hiroshi Tanaka, Ryo Chinzei, Tsukasa Ishida, Atsuhiro Masuda, Hideyuki Shiomi, Yoshinori Morita, Masaru Yoshida, Hiromu Kutsumi, Hideto Inokuchi, Minoru Doita, Masahiro Kurosaka, Takeshi Azuma

  2007, Internal medicine (Tokyo, Japan), 46(13) (13), 927 - 31, English, Domestic magazine

  [Refereed]

  Scientific journal


• Diagnostic significance of gently sloping depression and irregular margin in superficial elevated colorectal tumors.

  Takako Nakahara, Nobuo Aoyama, Shuji Maekawa, Takao Tamura, Daisuke Shirasaka, Kohei Kuroda, Chiharu Nishioka, Yoshinori Morita, Masato Kasuga

  Jan. 2007, International journal of colorectal disease, 22(1) (1), 25 - 31, English, International magazine

  Scientific journal


• 早期胃癌に対する内視鏡的粘膜下層剥離術(ESD)におけるLansoprazole術前投与による病変視認性に関する検討

  MORITA YOSHINORI

  (株)メディカルレビュー社, Dec. 2006, The GI Forefront, 2(2) (2), 178 - 178, Japanese


• Hemosuccus pancreaticus

  KUTSUMI HIROMU, MORITA YOSHINORI, YOSHIDA MASARU

  Dec. 2006, Clinical gastroenterology and hepatology, Vol. 4, No. 12, pp. xx-xx, English

  Scientific journal


• HER-2 overexpression and targeted treatment by trastuzumab in a very old patient with gastric cancer

  T. Inui, A. Asakawa, Y. Morita, S. Mizuno, T. Natori, A. Kawaguchi, M. Murakami, Y. Hishikawa, A. Inui

  Nov. 2006, Journal of Internal Medicine, 260(5) (5), 484 - 487, English

  [Refereed]

  Scientific journal


• 当施設におけるH.pylori薬剤耐性と年次推移の現状

  Aoyama Nobuo, Shirasaka Daisuke, MORITA YOSHINORI

  (一財)日本消化器病学会, Sep. 2006, 日本消化器病学会雑誌, 103(臨増大会) (臨増大会), A781 - A781, Japanese

  International conference proceedings


• 遠位食道の組織学的変化に及ぼすHelicobacter pylori除菌療法の影響(Impact of Helicobacter pylori eradication therapy on histological change in the distal esophagus)

  Shirasaka Daisuke, MORITA YOSHINORI, Aoyama Nobuo

  (一財)日本消化器病学会, Sep. 2006, 日本消化器病学会雑誌, 103(臨増大会) (臨増大会), A764 - A764, Japanese

  International conference proceedings


• 胃排出能はPPI(低酸状態)で遅延するが、消化管運動改善薬の併用で可逆性である

  Aoyama Nobuo, Shirasaka Daisuke, MORITA YOSHINORI

  (一財)日本消化器病学会, Sep. 2006, 日本消化器病学会雑誌, 103(臨増大会) (臨増大会), A790 - A790, Japanese

  International conference proceedings


• Metronidazole(MNZ),Levofloxacin(LVFX)を用いたH.pylori再除菌の有効性と安全性について

  Shirasaka Daisuke, Aoyama Nobuo, MORITA YOSHINORI

  (一財)日本消化器病学会, Sep. 2006, 日本消化器病学会雑誌, 103(臨増大会) (臨増大会), A782 - A782, Japanese

  International conference proceedings


• Helicobacter pylori胃炎におけるMetallothioneinの役割と除菌後の変化に関する検討

  Shirasaka Daisuke, MORITA YOSHINORI

  (一財)日本消化器病学会, Sep. 2006, 日本消化器病学会雑誌, 103(臨増大会) (臨増大会), A785 - A785, Japanese

  International conference proceedings


• Helicobacter pyloriのlevofloxacin耐性診断におけるE-testとgyrA mutationの関係

  Shirasaka Daisuke, MORITA YOSHINORI

  (一財)日本消化器病学会, Sep. 2006, 日本消化器病学会雑誌, 103(臨増大会) (臨増大会), A783 - A783, Japanese

  International conference proceedings


• BRAF遺伝子変異平坦・陥凹型早期大腸癌における臨床病理学的検討

  MORITA YOSHINORI, Shirasaka Daisuke, Aoyama Nobuo

  (一財)日本消化器病学会, Sep. 2006, 日本消化器病学会雑誌, 103(臨増大会) (臨増大会), A884 - A884, Japanese

  International conference proceedings


• 神戸大学医学部附属医学医療国際交流センター難治性疾患病態解析分野(消化器外科) (各科の話題と専門外来)

  東 健, 森田 圭紀, 久津見 弘, 吉田 優

  神戸大学, Aug. 2006, 神戸大学医学部神緑会学術誌, 22, 86 - 87, Japanese


• Primary levofloxacin resistance and gyrA/B mutations among Helicobacter pylori in Japan.

  Hideyuki Miyachi, Ikuya Miki, Nobuo Aoyama, Daisuke Shirasaka, Yuko Matsumoto, Masanori Toyoda, Toshifumi Mitani, Yoshinori Morita, Takao Tamura, Shohiro Kinoshita, Yoshie Okano, Shunichi Kumagai, Masato Kasuga

  Aug. 2006, Helicobacter, 11(4) (4), 243 - 9, English, International magazine

  Scientific journal


• Helicobacter pylori eradication therapy on histologic change in the distal esophagus.

  Masanori Toyoda, Daisuke Shirasaka, Nobuo Aoyama, Yoshinori Watanabe, Ikuya Miki, Yoshinori Morita, Yuko Matsumoto, Toshifumi Mitani, Hideyuki Miyachi, Takao Tamura, Masato Kasuga

  Aug. 2006, Helicobacter, 11(4) (4), 217 - 23, English, International magazine

  Scientific journal


• 内視鏡拡張術が奏功したクローン病の症例

  Aoyama Nobuo, MORITA YOSHINORI

  (株)インフォノーツパブリッシング, Jul. 2006, 機能性食品と薬理栄養, 3(5) (5), 362 - 363, Japanese

  Scientific journal


• 形態診断に難渋した大腸陥凹性病変の2例

  MORITA YOSHINORI, Shirasaka Daisuke, Aoyama Nobuo

  (株)日本メディカルセンター, Jul. 2006, 早期大腸癌, 10(4) (4), 359 - 359, Japanese

  International conference proceedings


• Effects of Helicobacter pylori eradication therapy on gastric emptying measured using the 13C-octanoic acid breath test and the acetaminophen method.

  Masaaki Kachi, Daisuke Shirasaka, Nobuo Aoyama, Shigeyuki Ebara, Ikuya Miki, Yoshinori Morita, Takao Tamura, Masato Kasuga

  May 2006, Journal of gastroenterology and hepatology, 21(5) (5), 824 - 30, English, International magazine

  Scientific journal


• Where does the antimicrobial resistance of Helicobacter pylori come from, acquired after birth or inherited from parents? Different mechanism between clarithromycin and levofloxacin

  Naomi Torio, Mutsuko Konno, Ikuya Miki, Daisuke Shirasaka, Yoshinori Morita, Yuko Matsumoto, Hideyuki Miyachi, Takao Tamura, Nobuo Aoyama

  Apr. 2006, GASTROENTEROLOGY, 130(4) (4), A572 - A572, English

  [Refereed]


• Mutation analysis in the gyrA gene, not the E test, can be a powerful predictor for treatment outcomes of Helicobacter pylori infection with levofloxacin-based therapy

  Miki Ikuya, Shirasaka Daisuke, Miyachi Hideyuki, Matsumoto Yuko, Tamura Takao, Morita Yoshinori, Toyoda Masanori, Mitani Toshifumi, Torio Naomi, Aoyama Nobuo

  Apr. 2006, GASTROENTEROLOGY, 130(4) (4), A574

  [Refereed]


• 内視鏡的治療のトレーニング法とその評価 当院におけるESD(内視鏡的粘膜下層剥離術)普及に向けての取り組み

  MORITA YOSHINORI

  (一社)日本消化器内視鏡学会, Apr. 2006, Gastroenterological Endoscopy, 48(Suppl.1) (Suppl.1), 602 - 602, Japanese

  International conference proceedings


• 内視鏡的治療における偶発症とその予防 早期胃癌に対する安全確実なESDを目指して こだわりの高周波電源設定

  MORITA YOSHINORI

  (一社)日本消化器内視鏡学会, Apr. 2006, Gastroenterological Endoscopy, 48(Suppl.1) (Suppl.1), 680 - 680, Japanese

  International conference proceedings


• 内視鏡手技における私の工夫 早期胃癌に対するESD困難症例の克服 Double scope-ESDの開発

  MORITA YOSHINORI

  (一社)日本消化器内視鏡学会, Apr. 2006, Gastroenterological Endoscopy, 48(Suppl.1) (Suppl.1), 669 - 669, Japanese

  International conference proceedings


• 内視鏡の洗浄・消毒は満足するものに到達できたか 内視鏡洗浄消毒過程におけるATP測定による清浄度管理の有用性

  MORITA YOSHINORI, Aoyama Nobuo

  (一社)日本消化器内視鏡学会, Apr. 2006, Gastroenterological Endoscopy, 48(Suppl.1) (Suppl.1), 855 - 855, Japanese

  International conference proceedings


• 当院におけてEMR後経過観察に行った胃SM1癌の検討

  MORITA YOSHINORI, Aoyama Nobuo

  (一社)日本消化器内視鏡学会, Apr. 2006, Gastroenterological Endoscopy, 48(Suppl.1) (Suppl.1), 769 - 769, Japanese

  International conference proceedings


• 当院での高齢者における胃の内視鏡的粘膜下層剥離術(ESD)の現状

  MORITA YOSHINORI, Aoyama Nobuo

  (一社)日本消化器内視鏡学会, Apr. 2006, Gastroenterological Endoscopy, 48(Suppl.1) (Suppl.1), 753 - 753, Japanese

  International conference proceedings


• 大腸内視鏡における内視鏡切除後の出血対策について

  Aoyama Nobuo, MORITA YOSHINORI

  (一社)日本消化器内視鏡学会, Apr. 2006, Gastroenterological Endoscopy, 48(Suppl.1) (Suppl.1), 746 - 746, Japanese

  International conference proceedings


• 早期癌に対する内視鏡的治療後の遺残・再発にどう対処するのか 下部消化管 当院におけるLST病変に対する治療戦略

  MORITA YOSHINORI

  (一社)日本消化器内視鏡学会, Apr. 2006, Gastroenterological Endoscopy, 48(Suppl.1) (Suppl.1), 632 - 632, Japanese

  International conference proceedings


• 安全なESDのための高周波発生装置(ESU)使用マニュアルの作成と有用性

  MORITA YOSHINORI, Aoyama Nobuo

  (一社)日本消化器内視鏡学会, Apr. 2006, Gastroenterological Endoscopy, 48(Suppl.1) (Suppl.1), 867 - 867, Japanese

  International conference proceedings


• ESDにて一括完全切除し得た幽門輪より十二指腸球部内へ全周性に進展した早期胃癌の1例

  MORITA YOSHINORI

  (一社)日本消化器内視鏡学会, Apr. 2006, Gastroenterological Endoscopy, 48(Suppl.1) (Suppl.1), 697 - 697, Japanese

  International conference proceedings


• H.pylori除菌前後の下部食道における組織学的変化の検討

  Shirasaka Daisuke, Aoyama Nobuo, MORITA YOSHINORI

  (一財)日本消化器病学会, Mar. 2006, 日本消化器病学会雑誌, 103(臨増総会) (臨増総会), A218 - A218, Japanese

  International conference proceedings


• H.pyloriに対するレボフロキサシンを用いた2次除菌療法の有効性と安全性の検討

  Shirasaka Daisuke, MORITA YOSHINORI

  (一財)日本消化器病学会, Mar. 2006, 日本消化器病学会雑誌, 103(臨増総会) (臨増総会), A250 - A250, Japanese

  International conference proceedings


• Mosapride improves food intake, while not worsening glycemic control and obesity, in ob/ob obese mice with decreased gastric emptying

  Akihiro Asakawa, Naohiko Ueno, Miwako Katagi, Yuka Ijuin, Yoshinori Morita, Shigeto Mizuno, Toshio Inui, Ruka Sakamaki, Naotaka Shinfuku, Msaharu Uemoto

  Jan. 2006, Journal of Diabetes and its Complications, 20(1) (1), 56 - 58, English

  [Refereed]

  Scientific journal


• Helicobacter pylori infection is associated with colon adenomatous polyps detected by high-resolution colonoscopy.

  Shigeto Mizuno, Yoshinori Morita, Toshio Inui, Akihiro Asakawa, Naohiko Ueno, Takashi Ando, Haruki Kato, Mutsumi Uchida, Toshikazu Yoshikawa, Akio Inui

  Dec. 2005, International journal of cancer, 117(6) (6), 1058 - 9, English, International magazine

  [Refereed]

  Scientific journal


• [Recent trends in first-line therapy for H. pylori infection in the world].

  Ikuya Miki, Daisuke Shirasaka, Yoshinori Morita, Nobuo Aoyama

  Nov. 2005, Nihon rinsho. Japanese journal of clinical medicine, 63 Suppl 11, 418 - 20, Japanese, Domestic magazine

  Scientific journal


• Levofloxacin-versus metronidazole-based rescue therapy for H-pylori infection in Japan

  Y Matsumoto, Miki, I, N Aoyama, D Shirasaka, Y Watanabe, Y Morita, M Toyoda, T Mitani, H Miyachi, T Tamura, M Kasuga

  Nov. 2005, DIGESTIVE AND LIVER DISEASE, 37(11) (11), 821 - 825, English

  Scientific journal


• Role of metallothionein in Helicobacter pylori-positive gastric mucosa with or without early gastric cancer and the effect on its expression after eradication therapy

  Morita Yoshinori, Tamura Takao, Azuma Takeshi

  (一財)日本消化器病学会, Sep. 2005, Journal Of Gastroenterology And Hepatology, 102(臨増大会) (臨増大会), A712 - A712, Japanese

  Scientific journal


• Circadian variability of pharmacokinetics of 5-fluorouracil and CLOCK T3111C genetic polymorphism in patients with esophageal carcinoma.

  Ikuya Miki, Takao Tamura, Tsutomu Nakamura, Hiroo Makimoto, Noriko Hamana, Hitoshi Uchiyama, Daisuke Shirasaka, Yoshinori Morita, Hiroyuki Yamada, Nobuo Aoyama, Toshiyuki Sakaeda, Katsuhiko Okumura, Masato Kasuga

  Jun. 2005, Therapeutic drug monitoring, 27(3) (3), 369 - 74, English, International magazine

  [Refereed]

  Scientific journal


• Images of early cancer: Esophageal squamous-cell carcinoma

  T Ponchon, H Makuuchi, Y Morita, M Fukuda, T Mitani, D Shirasaka, N Aoyama, Y Amano, Moriyama, I, T Oose, Y Kinoshita

  Sep. 2004, ENDOSCOPY, 36(9) (9), 811 - 820, English

  [Refereed]

  Scientific journal


• 食道扁平上皮癌の根治的放射線化学療法における5-FU血中濃度の治療効果への影響

  三木生也, TAMURA, Takao, 奥野達哉, MORITA, Yoshinori, SHIRASAKA, Daisuke, 宮崎博之, 津田政弘, YAMADA, Hiroyuki, 浜名則子, 山田敏雄, SAKAEDA, Toshiyuki, AOYAMA, Nobuo

  (一社)日本癌治療学会, Sep. 2004, 日本癌治療学会誌, 39(2) (2), 656 - 656, Japanese

  International conference proceedings


• gemcitabineを用いた放射線化学療法が著効した症例の検討

  茶屋原菜穂子, TAMURA, Takao, SHIRASAKA, Daisuke, 奥野達哉, MORITA, Yoshinori, 三木生也, 宮崎博之, 津田正弘, YAMADA, Hiroyuki, AOYAMA, Nobuo, KASUGA, Masato

  (一社)日本癌治療学会, Sep. 2004, 日本癌治療学会誌, 39(2) (2), 567 - 567, Japanese

  International conference proceedings


• I s型大腸sm癌の一例

  豊田昌徳, AOYAMA, Nobuo, TAMURA, Takao, SHIRASAKA, Daisuke, 中原貴子, 西岡千晴, MORITA, Yoshinori, 三木生也, 加地正明, 大須賀達也, 福田昌輝, 前川維久子, 松本優子, 奥野達哉, 三谷年史, MAEKAWA,Shuji, YOKOZAKI, Hiroshi, SENBA, Shiyuhou, 池原伸直, 蓮尾直輝

  (株)日本メディカルセンター, Jul. 2004, 早期大腸癌, 8(4) (4), 339 - 339, Japanese

  International conference proceedings


• 内視鏡室における安全管理 神戸大学光学医療診療部におけるマシンマネージメント

  吉村兼, SHIRASAKA, Daisuke, MORITA, Yoshinori, MAEKAWA,Shuji, AOYAMA, Nobuo

  (一社)日本消化器内視鏡学会, Apr. 2004, 日本消化器内視鏡学会雑誌, 46(Suppl.1) (Suppl.1), 765 - 765, Japanese

  International conference proceedings


• 陥凹局面をもつ平坦隆起病変にIs様の隆起部が混在した早期大腸癌の1例

  大須賀達也, AOYAMA, Nobuo, TAMURA, Takao, SHIRASAKA, Daisuke, MAEKAWA,Shuji, MORITA, Yoshinori, 西岡千晴, 中原貴子, 三木生也, 加地正明, 渡部義則, 福田昌輝, WamburaCasmir, KASUGA, Masato, 池原伸直, SENBA, Shiyuhou, YOKOZAKI, Hiroshi

  (株)日本メディカルセンター, Jul. 2003, 早期大腸癌, 7(4) (4), 375 - 375, Japanese

  International conference proceedings


• 大腸腫瘍におけるPKCλの免疫組織学的検討

  中原貴子, AOYAMA, Nobuo, SHIRASAKA, Daisuke, MAEKAWA,Shuji, TAMURA, Takao, MORITA, Yoshinori, 西岡千晴, 大須賀達也, 池原伸直, カスミール・ワンブラ, 三木生也, 加地正明, 福田昌輝, KASUGA, Masato

  (一社)日本消化器内視鏡学会, Apr. 2003, 日本消化器内視鏡学会雑誌, 45(Suppl.1) (Suppl.1), 654 - 654, Japanese

  International conference proceedings


• MDR1 genotype-related duodenal absorption rate of digoxin in healthy Japanese subjects.

  Yoshinori Morita, Toshiyuki Sakaeda, Masanori Horinouchi, Tsutomu Nakamura, Kohei Kuroda, Ikuya Miki, Ken Yoshimura, Toshiyuki Sakai, Daisuke Shirasaka, Takao Tamura, Nobuo Aoyama, Masato Kasuga, Katsuhiko Okumura

  Apr. 2003, Pharmaceutical research, 20(4) (4), 552 - 6, English, International magazine

  [Refereed]

  Scientific journal


• Prospect of endoscopic mucosal resection for early gastric cancer: Our devices in insulated-tip electrosurgical knife method

  Yoshinori Morita, Nobuo Aoyama, Daisuke Shirasaka, Masateru Fukuda, Masato Kasuga

  2003, Digestive Endoscopy, 15, S12 - S14, English

  [Refereed]

  International conference proceedings


• Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: functional relevance to pharmacokinetics of digoxin.

  Masanori Horinouchi, Toshiyuki Sakaeda, Tsutomu Nakamura, Yoshinori Morita, Takao Tamura, Nobuo Aoyama, Masato Kasuga, Katsuhiko Okumura

  Oct. 2002, Pharmaceutical research, 19(10) (10), 1581 - 5, English, International magazine

  [Refereed]

  Scientific journal


• MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects

  T. Sakaeda, T. Nakamura, M. Horinouchi, M. Kakumoto, N. Ohmoto, T. Sakai, Y. Morita, T. Tamura, N. Aoyama, M. Hirai, M. Kasuga, K. Okumura

  2001, Pharmaceutical Research, 18(10) (10), 1400 - 1404, English

  [Refereed]

  Scientific journal

• 非乳頭部十二指腸腫瘍の内視鏡診療 表在性非乳頭部十二指腸上皮性腫瘍に対するD-LECSの治療成績と合併症の特徴についての検討

  高山 弘志, 森田 圭紀, 豊永 高史

  (一社)日本消化器内視鏡学会, Oct. 2023, Gastroenterological Endoscopy, 65(Suppl.2) (Suppl.2), 1937 - 1937, Japanese


• 消化管腫瘍に対する内視鏡診療の現況と展望 食道内視鏡治療後の多発病変に対する再内視鏡治療困難症例の臨床的特徴

  石田 亮介, 吉崎 哲也, 森田 圭紀, 豊永 高史, 児玉 裕三

  日本消化器内視鏡学会-近畿支部, Jun. 2023, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 110回, 76 - 76, Japanese


• 当院での虫垂開口部の大腸病変に対するESDの治療戦略と成績

  津田 一範, 吉崎 哲也, 豊永 高史, 永木 瑞穂, 石田 亮介, 堀 瞳, 高山 弘志, 上田 千勢, 阪口 博哉, 阿部 洋文, 池澤 伸明, 鷹尾 まど佳, 鷹尾 俊達, 森田 圭紀, 児玉 裕三

  (一社)日本消化器内視鏡学会, Apr. 2023, Gastroenterological Endoscopy, 65(Suppl.1) (Suppl.1), 892 - 892, Japanese


• 消化器疾患の遠隔医療の現状と課題 消化器内視鏡分野への5G遠隔通信システム応用の取り組み

  前田 充毅, 内多 訓久, 森田 圭紀

  (一財)日本消化器病学会, Mar. 2023, 日本消化器病学会雑誌, 120(臨増総会) (臨増総会), A154 - A154, Japanese


• 胃・十二指腸ESDにおける高難度症例への対処 幽門輪に接する胃・十二指腸腫瘍に対するESD治療成績と術後合併症の検討

  高山 弘志, 豊永 高史, 池澤 伸明, 吉崎 哲也, 阿部 洋文, 阪口 博哉, 鷹尾 俊達, 森田 圭紀, 児玉 裕三

  (一社)日本胃癌学会, Feb. 2023, 日本胃癌学会総会記事, 95回, 228 - 228, Japanese


• 消化器内視鏡分野への5Gを用いた遠隔通信システムの有用性における検討

  前田 充毅, 内多 訓久, 小原 英幹, 森田 圭紀, 大西 智之

  (一社)日本胃癌学会, Feb. 2023, 日本胃癌学会総会記事, 95回, 545 - 545, Japanese


• 食道胃接合部癌に対する治療戦略 当院でESD治療を施行した食道胃接合部腺癌の深達度診断に関する検討

  堀 瞳, 吉崎 哲也, 森田 圭紀, 児玉 裕三

  日本消化器病学会-近畿支部, Jan. 2023, 日本消化器病学会近畿支部例会プログラム・抄録集, 118回, 55 - 55, Japanese


• 経時的に形態変化を観察し得た表在性非乳頭部十二指腸上皮性腫瘍の一例

  永木 瑞穂, 池澤 伸明, 堀 瞳, 石田 亮介, 高山 弘志, 津田 一範, 阪口 博哉, 阿部 洋文, 吉崎 哲也, 鷹尾 まど佳, 鷹尾 俊達, 森田 圭紀, 豊永 高史, 児玉 裕三

  日本消化器内視鏡学会-近畿支部, Nov. 2022, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 109回, 103 - 103, Japanese


• 5Gを用いた消化器内視鏡遠隔診断・治療システムの開発

  森田 圭紀, 鷹尾 まど佳, 高山 弘志, 千代 大翔, 小原 英幹, 前田 充毅, 岩崎 丈紘, 内多 訓久

  (一社)日本消化器内視鏡学会, Oct. 2022, Gastroenterological Endoscopy, 64(Suppl.2) (Suppl.2), 2148 - 2148, Japanese


• 5Gを用いた消化器内視鏡遠隔診断・治療システムの開発

  森田 圭紀, 鷹尾 まど佳, 高山 弘志, 千代 大翔, 小原 英幹, 前田 充毅, 岩崎 丈紘, 内多 訓久

  (一社)日本消化器内視鏡学会, Oct. 2022, Gastroenterological Endoscopy, 64(Suppl.2) (Suppl.2), 2148 - 2148, Japanese


• 5G回線を使用した遠隔通信システムの消化器内視鏡分野応用の有用性の検討

  前田 充毅, 内多 訓久, 小原 英幹, 森田 圭紀, 大西 智之

  日本赤十字社医学会, Sep. 2022, 日赤医学, 72(1) (1), 185 - 185, Japanese


• Next Endoscopy-消化器内視鏡技術開発のBreak through 5Gを用いた消化器内視鏡遠隔診断・治療システムの開発

  森田 圭紀, 小原 英幹, 内多 訓久

  (一社)日本消化器内視鏡学会, Apr. 2022, Gastroenterological Endoscopy, 64(Suppl.1) (Suppl.1), 688 - 688, Japanese


• 優れた防曇・防汚性能を有する内視鏡フードに関する研究開発・事業化

  嶋本 有策, 高山 弘志, 森田 圭紀

  (一社)日本消化器内視鏡学会, Apr. 2022, Gastroenterological Endoscopy, 64(Suppl.1) (Suppl.1), 854 - 854, Japanese


• Next Endoscopy-消化器内視鏡技術開発のBreak through 5Gを用いた消化器内視鏡遠隔診断・治療システムの開発

  森田 圭紀, 小原 英幹, 内多 訓久

  (一社)日本消化器内視鏡学会, Apr. 2022, Gastroenterological Endoscopy, 64(Suppl.1) (Suppl.1), 688 - 688, Japanese


• 優れた防曇・防汚性能を有する内視鏡フードに関する研究開発・事業化

  嶋本 有策, 高山 弘志, 森田 圭紀

  (一社)日本消化器内視鏡学会, Apr. 2022, Gastroenterological Endoscopy, 64(Suppl.1) (Suppl.1), 854 - 854, Japanese


• ESD traineeからExpertを目指して

  池澤 伸明, 森田 圭紀, 中井 達也, 津田 一範, 賀来 英俊, 松本 慶, 阪口 博哉, 阿部 洋文, 吉崎 哲也, 田中 心和, 鷹尾 まど佳, 鷹尾 俊達, 豊永 高史, 児玉 裕三

  (一社)日本胃癌学会, Mar. 2022, 日本胃癌学会総会記事, 94回, 515 - 515, Japanese


• ESD traineeからExpertを目指して

  池澤 伸明, 森田 圭紀, 中井 達也, 津田 一範, 賀来 英俊, 松本 慶, 阪口 博哉, 阿部 洋文, 吉崎 哲也, 田中 心和, 鷹尾 まど佳, 鷹尾 俊達, 豊永 高史, 児玉 裕三

  (一社)日本胃癌学会, Mar. 2022, 日本胃癌学会総会記事, 94回, 515 - 515, Japanese


• 胃粘膜萎縮の程度は早期胃癌に対するESD後出血の発生に関与する

  岡川 泰, 住吉 徹哉, 林 義人, 八田 和久, 辻 陽介, 由雄 敏之, 角嶋 直美, 布袋屋 修, 土山 寿志, 永見 康明, 引地 拓人, 小林 雅邦, 森田 圭紀, 井口 幹崇, 富田 英臣, 井上 拓也, 三上 達也, 浦岡 俊夫, 藤城 光弘, 近藤 仁, FIGHT-Japan study group

  (一社)日本消化管学会, Jan. 2022, 日本消化管学会雑誌, 6(Suppl.) (Suppl.), 87 - 87, Japanese


• 胃腫瘍内視鏡治療における工夫 幽門側胃切除後の残胃吻合部の早期胃癌に対する内視鏡的粘膜下層剥離術の再建術式に基づく治療困難性および有効性、安全性の検討

  松本 慶, 鷹尾 俊達, 田中 心和, 森田 圭紀, 豊永 高史, 児玉 裕三

  (一社)日本消化管学会, Jan. 2022, 日本消化管学会雑誌, 6(Suppl.) (Suppl.), 168 - 168, Japanese


• 胃粘膜萎縮の程度は早期胃癌に対するESD後出血の発生に関与する

  岡川 泰, 住吉 徹哉, 林 義人, 八田 和久, 辻 陽介, 由雄 敏之, 角嶋 直美, 布袋屋 修, 土山 寿志, 永見 康明, 引地 拓人, 小林 雅邦, 森田 圭紀, 井口 幹崇, 富田 英臣, 井上 拓也, 三上 達也, 浦岡 俊夫, 藤城 光弘, 近藤 仁, FIGHT-Japan study group

  (一社)日本消化管学会, Jan. 2022, 日本消化管学会雑誌, 6(Suppl.) (Suppl.), 87 - 87, Japanese


• 胃腫瘍内視鏡治療における工夫 幽門側胃切除後の残胃吻合部の早期胃癌に対する内視鏡的粘膜下層剥離術の再建術式に基づく治療困難性および有効性、安全性の検討

  松本 慶, 鷹尾 俊達, 田中 心和, 森田 圭紀, 豊永 高史, 児玉 裕三

  (一社)日本消化管学会, Jan. 2022, 日本消化管学会雑誌, 6(Suppl.) (Suppl.), 168 - 168, Japanese


• 低分化型腺癌と鑑別を要した乳癌胃転移の一例

  井上 築, 吉崎 哲也, 中井 達也, 高山 弘志, 津田 一範, 松本 慶, 賀来 英俊, 阪口 博哉, 阿部 洋文, 池澤 伸明, 鷹尾 まど佳, 鷹尾 俊達, 森田 圭紀, 豊永 高史, 児玉 裕三

  日本消化器内視鏡学会-近畿支部, Dec. 2021, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 107回, 113 - 113, Japanese


• Barrett食道腺癌ESD後の異時性多発病変に対し残存Barrett粘膜を含めESDで完全切除した一例

  津田 一範, 豊永 高史, 高山 弘志, 阿部 洋文, 中井 達也, 嶋本 有策, 賀来 英俊, 松本 慶, 池澤 伸明, 阪口 博哉, 吉崎 哲也, 鷹尾 まど佳, 鷹尾 俊達, 森田 圭紀, 児玉 裕三

  日本消化器内視鏡学会-近畿支部, Dec. 2021, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 107回, 120 - 120, Japanese


• 胃前庭部の粘膜下層剥離術後通過障害に対するバルーン拡張術無効例の検討

  高山 弘志, 豊永 高史, 吉崎 哲也, 中井 達也, 賀来 英俊, 松本 慶, 津田 一範, 阪口 博哉, 阿部 洋文, 池澤 伸明, 鷹尾 まど佳, 鷹尾 俊達, 森田 圭紀, 児玉 裕三

  日本消化器内視鏡学会-近畿支部, Dec. 2021, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 107回, 121 - 121, Japanese


• 消化器チーム医療における医工連携 当院における産学・医工連携による消化器内視鏡分野への取り組み

  森田 圭紀, 鷹尾 まど佳, 市之瀬 透

  (一社)日本消化器がん検診学会, Oct. 2021, 日本消化器がん検診学会雑誌, 59(Suppl大会) (Suppl大会), 654 - 654, Japanese


• 当院における産学・医工連携による消化器内視鏡分野への取り組み

  森田 圭紀, 鷹尾 まど佳, 市之瀬 透

  (一社)日本消化器内視鏡学会, Oct. 2021, Gastroenterological Endoscopy, 63(Suppl.2) (Suppl.2), 1854 - 1854, Japanese


• 表在性非乳頭部十二指腸上皮性腫瘍に対する腹腔鏡内視鏡合同手術の当院の成績

  鷹尾 俊達, 森田 圭紀, 児玉 裕三

  (一社)日本消化器内視鏡学会, Oct. 2021, Gastroenterological Endoscopy, 63(Suppl.2) (Suppl.2), 1860 - 1860, Japanese


• 大腸腫瘍に対するEMR/ESDの新技術 当院における憩室内および近接病変に対する大腸ESDの治療成績と工夫

  池澤 伸明, 豊永 高史, 森田 圭紀

  (一社)日本消化器内視鏡学会, Oct. 2021, Gastroenterological Endoscopy, 63(Suppl.2) (Suppl.2), 1996 - 1996, Japanese


• 消化器チーム医療における医工連携 当院における産学・医工連携による消化器内視鏡分野への取り組み

  森田 圭紀, 鷹尾 まど佳, 市之瀬 透

  (一社)日本消化器がん検診学会, Oct. 2021, 日本消化器がん検診学会雑誌, 59(Suppl大会) (Suppl大会), 654 - 654, Japanese


• 早期胃癌で発見された胎児消化管上皮類似癌の3例

  山中 大樹, 池澤 伸明, 中井 達也, 高山 弘志, 上田 千勢, 津田 一範, 松本 慶, 賀来 英俊, 阪口 博哉, 阿部 洋文, 吉崎 哲也, 鷹尾 まど佳, 鷹尾 俊達, 森田 圭紀, 豊永 高史, 児玉 裕三

  日本消化器病学会-近畿支部, Sep. 2021, 日本消化器病学会近畿支部例会プログラム・抄録集, 115回, 68 - 68, Japanese


• 当院における産学・医工連携による消化器内視鏡分野への取り組み

  森田 圭紀, 鷹尾 まど佳, 市之瀬 透

  (一社)日本肝臓学会, Sep. 2021, 肝臓, 62(Suppl.2) (Suppl.2), A450 - A450, Japanese


• 【早期大腸癌内視鏡治療の新展開】大腸T1b癌を完全一括切除するために必要な内視鏡的切除技術

  豊永 高史, 阪口 博哉, 池澤 伸明, 中野 佳子, 田中 心和, 石田 司, 阿部 洋文, 吉崎 哲也, 鷹尾 俊達, 森田 圭紀, 馬場 慎一, 滝原 浩守, 西野 栄世, 横崎 宏, 児玉 裕三

  (株)医学書院, Jul. 2021, 胃と腸, 56(8) (8), 1047 - 1056, Japanese


• 下部消化管腫瘍性病変に対する内視鏡的切除方法の戦略 当院における憩室内および近接病変に対する大腸ESDの治療成績と工夫

  池澤 伸明, 豊永 高史, 森田 圭紀, 児玉 裕三

  日本消化器内視鏡学会-近畿支部, Jul. 2021, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 106回, 72 - 72, Japanese


• 正中弓状靱帯症候群に合併した後下膵十二指腸動脈瘤破裂に対するコイル塞栓後に十二指腸狭窄をきたした一例

  中辻 政志, 池澤 伸明, 鷹尾 俊達, 中井 達也, 賀来 英俊, 森田 圭紀, 豊永 高史, 児玉 裕三

  日本消化器内視鏡学会-近畿支部, Jul. 2021, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 106回, 96 - 96, Japanese


• 十二指腸表在型腫瘍に対する内視鏡診療(LECS vs EMR vs ESD vs経過観察) 表在型非乳頭部十二指腸上皮性腫瘍に対する腹腔鏡内視鏡合同手術の治療成績

  鷹尾 俊達, 森田 圭紀, 児玉 裕三

  (一社)日本消化器内視鏡学会, Apr. 2021, Gastroenterological Endoscopy, 63(Suppl.1) (Suppl.1), 848 - 848, Japanese


• 進行食道癌に対する食道ステント留置後の食事摂取状況に関する検討

  賀来 英俊, 鷹尾 俊達, 中井 達也, 高山 弘志, 嶋本 有策, 上田 千勢, 津田 一範, 松本 慶, 池澤 伸明, 阪口 博哉, 松岡 晃生, 阿部 洋文, 吉崎 哲也, 鷹尾 まど佳, 森田 圭紀, 豊永 高史, 児玉 裕三

  (一社)日本消化器内視鏡学会, Apr. 2021, Gastroenterological Endoscopy, 63(Suppl.1) (Suppl.1), 910 - 910, Japanese


• 幽門側胃切除後の残胃吻合部の早期胃癌に対する内視鏡的粘膜下層剥離術の再建術式に基づく治療困難性および有効性、安全性の検討

  松本 慶, 鷹尾 俊達, 田中 心和, 森田 圭紀, 豊永 高史, 児玉 裕三

  (一社)日本消化器内視鏡学会, Apr. 2021, Gastroenterological Endoscopy, 63(Suppl.1) (Suppl.1), 956 - 956, Japanese


• Endoscopic Resection Technique Used for Complete En Bloc Resection of T1b Colorectal Cancer

  豊永高史, 阪口博哉, 池澤伸明, 中野佳子, 田中心和, 石田司, 阿部洋文, 吉崎哲也, 鷹尾俊達, 森田圭紀, 馬場慎一, 滝原浩守, 西野栄世, 横崎宏, 児玉裕三

  2021, 胃と腸, 56(8) (8)


• 胃癌ESD後の追加外科切除に関する検討

  山本 将士, 金治 新悟, 裏川 直樹, 松田 佳子, 松田 佳子, 押切 太郎, 中村 哲, 鈴木 知志, 森田 圭紀, 掛地 吉弘

  (一社)日本消化器外科学会, Dec. 2020, 日本消化器外科学会総会, 75回, P049 - 1, Japanese


• Helicobacter pylori未感染胃に生じたラズベリー様腺窩上皮型胃癌の1例

  堀谷 晋, 松岡 晃生, 鷹尾 俊達, 田中 心和, 阿部 洋文, 森田 圭紀, 豊永 高史, 児玉 裕三

  日本消化器内視鏡学会-近畿支部, Dec. 2020, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 105回, 60 - 60, Japanese


• PGAシートにて胃ESD後遅発性穿孔を閉鎖し得た一例

  山本 顕, 賀来 英俊, 鷹尾 俊達, 中井 達也, 高山 弘志, 嶋本 有策, 上田 千勢, 津田 一範, 松本 慶, 池澤 伸明, 阪口 博哉, 松岡 晃生, 阿部 洋文, 吉崎 哲也, 鷹尾 まど佳, 森田 圭紀, 豊永 高史, 児玉 裕三

  日本消化器内視鏡学会-近畿支部, Dec. 2020, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 105回, 60 - 60, Japanese


• 表在性非乳頭部十二指腸上皮性腫瘍に対する治療戦略 表在型非乳頭部十二指腸上皮性腫瘍に対する腹腔鏡内視鏡合同手術の治療成績(膵臓側病変を含む)

  鷹尾 俊達, 森田 圭紀, 児玉 裕三

  (一社)日本消化器内視鏡学会, Aug. 2020, Gastroenterological Endoscopy, 62(Suppl.1) (Suppl.1), 1169 - 1169, Japanese


• 進化し続ける内視鏡診療に対するチーム医療の挑戦-教育・安全管理の側面から- 全身麻酔下での内視鏡治療にあたっての当院での取り組み

  松本 慶, 森田 圭紀, 児玉 裕三

  (一社)日本消化器内視鏡学会, Aug. 2020, Gastroenterological Endoscopy, 62(Suppl.1) (Suppl.1), 1197 - 1197, Japanese


• 早期胃癌ESD非治癒切除例における高齢者症例の検討

  阿部 洋文, 田中 心和, 豊永 高史, 森田 圭紀, 阪口 博哉, 児玉 裕三

  (一社)日本消化器内視鏡学会, Aug. 2020, Gastroenterological Endoscopy, 62(Suppl.1) (Suppl.1), 1278 - 1278, Japanese


• ガイドライン追補版導入後の抗血栓薬服用者における胃ESDの後出血に関する検討

  津田 一範, 田中 心和, 池澤 伸明, 阿部 洋文, 鷹尾 俊達, 森田 圭紀, 豊永 高史, 児玉 裕三

  (一社)日本消化器内視鏡学会, Aug. 2020, Gastroenterological Endoscopy, 62(Suppl.1) (Suppl.1), 1322 - 1322, Japanese


• 当院における産学・医工連携による消化器内視鏡分野への取り組み

  森田 圭紀, 鷹尾 俊達, 児玉 裕三, 阪口 博哉

  (一社)日本消化器内視鏡学会, Aug. 2020, Gastroenterological Endoscopy, 62(Suppl.1) (Suppl.1), 1359 - 1359, Japanese


• 軟性持針器を用いた内視鏡的胃全層縫合術の開発

  阪口 博哉, 鷹尾 俊達, 森田 圭紀

  (一社)日本消化器内視鏡学会, Aug. 2020, Gastroenterological Endoscopy, 62(Suppl.1) (Suppl.1), 1390 - 1390, Japanese


• 【大腸ESDの工夫】トラクション エンドトラック法

  阪口 博哉, 豊永 高史, 田中 心和, 鷹尾 俊達, 森田 圭紀, 児玉 裕三

  (株)日本メディカルセンター, Feb. 2020, 臨床消化器内科, 35(3) (3), 269 - 274, Japanese


• NSAIDs外用薬によって多発小腸潰瘍をきたした1例

  城端慧, 津田一範, 田中心話, 乾沙苗, 宮崎はる香, 徳永英里, 賀来英俊, 阿部洋文, 具潤亜, 迫智也, 池澤伸明, 若原ちか, 大井充, 鷹尾まど佳, 鷹尾俊達, 飛松和俊, 森田圭紀, 豊永高史, 児玉裕三

  日本消化器病学会-近畿支部, 2020, 日本消化器病学会近畿支部例会プログラム・抄録集, 112th, 110 - 110, Japanese


• レーザー内視鏡診療の現状と近未来 CO2レーザーによる次世代の内視鏡治療技術の開発

  森田 圭紀, 賀来 英俊, 児玉 裕三

  (一社)日本消化管学会, Jan. 2020, 日本消化管学会雑誌, 4(Suppl.) (Suppl.), 226 - 226, Japanese


• ガイドライン追補版導入後の抗血栓薬服用者における胃ESDの後出血に関する検討

  池澤 伸明, 田中 心和, 森田 圭紀, 豊永 高史, 児玉 裕三

  (一社)日本消化管学会, Jan. 2020, 日本消化管学会雑誌, 4(Suppl.) (Suppl.), 258 - 258, Japanese


• 肛門管切開を伴う内視鏡的粘膜下層剥離術(ESD)の術後狭窄の検討

  迫智也, 豊永高史, 豊永高史, 中野佳子, 田中心和, 鷹尾俊達, 森田圭紀, 児玉裕三

  (一社)日本消化管学会, 2020, 日本消化管学会雑誌, 4(Supplement) (Supplement), 265 - 265, Japanese


• Endo Trac

  阪口博哉, 豊永高史, 豊永高史, 田中心和, 田中心和, 森田圭紀, 森田圭紀, 児玉裕三

  (株)東京医学社, 2020, 消化器内視鏡, 32(6) (6), 805 - 808, Japanese


• 表在性非乳頭部十二指腸腫瘍に対する腹腔鏡内視鏡合同手術~腫瘍局在に応じた外科手技の工夫と治療成績~

  金治新悟, 森田圭紀, 鈴木知志, 山本将士, 瀧口豪介, 裏川直樹, 長谷川寛, 松田佳子, 山下公大, 松田武, 押切太郎, 豊永高史, 中村哲, 児玉裕三, 掛地吉弘

  (一社)日本外科学会, 2020, 日本外科学会定期学術集会(Web), 120th, SF - 6, Japanese


• 当院における憩室内および近接病変に対する大腸ESDの治療成績と工夫

  池澤伸明, 豊永高史, 森田圭紀, 児玉裕三

  日本消化器病学会-近畿支部, 2020, 日本消化器病学会近畿支部例会プログラム・抄録集, 113th, 70 - 70, Japanese


• CO2レーザーによる次世代の内視鏡治療技術の開発

  森田圭紀, 森田圭紀, 賀来英俊, 児玉裕三

  (一社)日本消化管学会, 2020, 日本消化管学会雑誌, 4(Supplement) (Supplement), 226 - 226, Japanese


• 消化器がん術後の縫合不全・瘻孔に対するポリグリコール酸(PGA)シートとフィブリン接着剤の有効性 多施設遡及的研究

  松浦 倫子, 青柳 裕之, 滝本 見吾, 辻 陽介, 小野 裕之, 滝沢 耕平, 森田 圭紀, 竹内 洋司, 永見 康明, 平澤 欣吾, 荒木 寛司, 山口 直之, 松橋 保, 飯塚 敏郎, 三枝 久能, 山崎 健路, 堀 伸一郎, 万波 智彦, 鼻岡 昇, 森 宏仁, PGA Study Group

  (一社)日本消化器内視鏡学会, Oct. 2019, Gastroenterological Endoscopy, 61(Suppl.2) (Suppl.2), 2142 - 2142, Japanese


• 食道癌集学的治療Up to Date 内視鏡治療後非治癒切除症例に対する食道切除術の意義と適応

  中村 哲, 小寺澤 康文, 瀧口 豪介, 裏川 直樹, 長谷川 寛, 山本 将士, 田中 心和, 金治 新悟, 松田 佳子, 山下 公大, 森田 圭紀, 松田 武, 押切 太郎, 鈴木 知志, 掛地 吉弘

  (一社)日本癌治療学会, Oct. 2019, 日本癌治療学会学術集会抄録集, 57回, SY18 - 5, English


• 胃・十二指腸腫瘍に対する内科・外科合同手術の現状と展望 表在型非乳頭部十二指腸上皮性腫瘍に対する腹腔鏡内視鏡合同手術の検討 内視鏡医の立場から

  迫 智也, 森田 圭紀, 金治 新悟, 児玉 裕三

  日本消化器病学会-近畿支部, Oct. 2019, 日本消化器病学会近畿支部例会プログラム・抄録集, 111回, 51 - 51, Japanese


• 短期間で増大傾向を示した十二指腸低分化腺癌/印環細胞癌の一例

  土井 真由実, 迫 智也, 鷹尾 俊達, 池澤 伸明, 田中 心和, 森田 圭紀, 豊永 高史, 児玉 裕三

  日本消化器病学会-近畿支部, Oct. 2019, 日本消化器病学会近畿支部例会プログラム・抄録集, 111回, 74 - 74, Japanese


• バルーン拡張術が有効であったPlummer-vinson症候群の一例

  津田 一範, 田中 心和, 阿部 洋文, 若原 ちか, 浦上 聡, 朝治 直紀, 松本 慶, 池澤 伸明, 賀来 英俊, 阪口 博哉, 迫 智也, 鷹尾 まど佳, 鷹尾 俊達, 森田 圭紀, 豊永 高史, 児玉 裕三

  日本消化器病学会-近畿支部, Oct. 2019, 日本消化器病学会近畿支部例会プログラム・抄録集, 111回, 109 - 109, Japanese


• 消化器がん術後の縫合不全・瘻孔に対するポリグリコール酸(PGA)シートとフィブリン接着剤の有効性 多施設遡及的研究

  松浦 倫子, 青柳 裕之, 滝本 見吾, 辻 陽介, 小野 裕之, 滝沢 耕平, 森田 圭紀, 竹内 洋司, 永見 康明, 平澤 欣吾, 荒木 寛司, 山口 直之, 松橋 保, 飯塚 敏郎, 三枝 久能, 山崎 健路, 堀 伸一郎, 万波 智彦, 鼻岡 昇, 森 宏仁, PGA Study Group

  (一社)日本消化器内視鏡学会, Oct. 2019, Gastroenterological Endoscopy, 61(Suppl.2) (Suppl.2), 2142 - 2142, Japanese


• 食道癌集学的治療Up to Date 内視鏡治療後非治癒切除症例に対する食道切除術の意義と適応

  中村 哲, 小寺澤 康文, 瀧口 豪介, 裏川 直樹, 長谷川 寛, 山本 将士, 田中 心和, 金治 新悟, 松田 佳子, 山下 公大, 森田 圭紀, 松田 武, 押切 太郎, 鈴木 知志, 掛地 吉弘

  (一社)日本癌治療学会, Oct. 2019, 日本癌治療学会学術集会抄録集, 57回, SY18 - 5, English


• 消化器領域におけるレーザー医療の進歩と課題 CO2レーザーによる次世代の内視鏡治療技術の開発

  森田 圭紀, 児玉 裕三, 日吉 勝海, 本郷 晃史, 岡上 吉秀, 間 久直, 粟津 邦男

  (NPO)日本レーザー医学会, Sep. 2019, 日本レーザー医学会誌, 40(3) (3), 233 - 233, Japanese


• キャリアサポートに関する女性内視鏡医へのアンケート調査結果

  原田 直彦, 平岡 佐規子, 中村 真一, 白鳥 敬子, 春間 賢, 河合 隆, 森田 圭紀, 横井 千寿, 南 ひとみ

  (一社)日本消化器内視鏡学会, Jun. 2019, Gastroenterological Endoscopy, 61(6) (6), 1264 - 1271, Japanese


• 消化管穿孔及び瘻孔症例に対するポリグリコール酸(PGA)シートとフィブリン接着剤の有効性 多施設遡及的研究PGA Study Group

  松浦 倫子, 竹内 洋司, 辻 陽介, 小野 裕之, 滝沢 耕平, 滝本 見吾, 森田 圭紀, 永見 康明, 平澤 欣吾, 荒木 寛司, 山口 直之, 青柳 裕之, 松橋 保, 飯塚 敏郎, 三枝 久能, 山崎 健路, 堀 伸一郎, 万波 智彦, 鼻岡 昇, 森 宏仁

  (一社)日本消化器内視鏡学会, May 2019, Gastroenterological Endoscopy, 61(Suppl.1) (Suppl.1), 1020 - 1020, Japanese


• 消化管穿孔及び瘻孔症例に対するポリグリコール酸(PGA)シートとフィブリン接着剤の有効性 多施設遡及的研究PGA Study Group

  松浦 倫子, 竹内 洋司, 辻 陽介, 小野 裕之, 滝沢 耕平, 滝本 見吾, 森田 圭紀, 永見 康明, 平澤 欣吾, 荒木 寛司, 山口 直之, 青柳 裕之, 松橋 保, 飯塚 敏郎, 三枝 久能, 山崎 健路, 堀 伸一郎, 万波 智彦, 鼻岡 昇, 森 宏仁

  (一社)日本消化器内視鏡学会, May 2019, Gastroenterological Endoscopy, 61(Suppl.1) (Suppl.1), 1020 - 1020, Japanese

  Summary national conference


• cT1大腸癌におけるESD穿孔症例の検討

  前原 律子, 松田 武, 長谷川 寛, 山下 公大, 角 泰雄, 石田 司, 田中 心和, 森田 圭紀, 豊永 高史, 梅垣 英次, 掛地 吉弘

  (一社)日本大腸肛門病学会, May 2019, 日本大腸肛門病学会雑誌, 72(5) (5), 355 - 355, Japanese


• 当院での粘膜切開生検法45例の検討 組織採取不成功例の検討を中心に

  鷹尾 俊達, 中野 佳子, 森田 圭紀

  (一社)日本消化器内視鏡学会, May 2019, Gastroenterological Endoscopy, 61(Suppl.1) (Suppl.1), 928 - 928, Japanese


• 当院で胃ESD後にPGAシートを貼付した16症例の検討

  阪口 博哉, 鷹尾 俊達, 森田 圭紀, 児玉 裕三

  (一社)日本消化器内視鏡学会, May 2019, Gastroenterological Endoscopy, 61(Suppl.1) (Suppl.1), 1019 - 1019, Japanese


• Transanal Endoscopic Microsurgery(TEM)後の遺残再発病変に対するESDの有用性と安全性についての検討

  池澤 伸明, 田中 心和, 石田 司, 中野 佳子, 鷹尾 俊達, 森田 圭紀, 梅垣 英次, 豊永 高史, 児玉 裕三

  (一社)日本消化器内視鏡学会, May 2019, Gastroenterological Endoscopy, 61(Suppl.1) (Suppl.1), 940 - 940, Japanese


• 肛門管切開を伴う内視鏡的粘膜下層剥離術(ESD)の術後狭窄の検討

  迫 智也, 中野 佳子, 豊永 高史, 田中 心和, 鷹尾 俊達, 森田 圭紀, 梅垣 英次, 児玉 裕三

  (一社)日本消化器内視鏡学会, May 2019, Gastroenterological Endoscopy, 61(Suppl.1) (Suppl.1), 946 - 946, Japanese


• 十二指腸腫瘍に対する腹腔鏡内視鏡合同手術の安全性に関する検討

  金治 新悟, 森田 圭紀, 鈴木 知志, 山本 将士, 瀧口 豪介, 高瀬 信尚, 長谷川 寛, 松田 佳子, 山下 公大, 松田 武, 押切 太郎, 豊永 高史, 中村 哲, 児玉 裕三, 掛地 吉弘

  (一社)日本外科学会, Apr. 2019, 日本外科学会定期学術集会抄録集, 119回, SF - 8, Japanese


• レーザーが切り拓く次世代の内視鏡治療に向けての取り組み

  森田圭紀, 有吉隆佑, 間久直, 粟津邦男, 児玉裕三

  (一社)日本消化管学会, Feb. 2019, 日本消化管学会雑誌, 3(Suppl.) (Suppl.), 168 - 168, Japanese


• 【胃癌診療アップデート】内視鏡治療

  MORITA YOSHINORI, TOYONAGA TAKASHI, KODAMA YUUZOU

  (株)へるす出版, Feb. 2019, 消化器外科, 42(2) (2), 145 - 151, Japanese

  Introduction scientific journal


• Transanal Endoscopic Microsurgery(TEM)後の遺残再発病変に対するESDの有用性と安全性についての検討

  池澤伸明, 田中心和, 石田司, 石田司, 中野佳子, 鷹尾俊達, 森田圭紀, 梅垣英次, 豊永高史, 豊永高史, 児玉裕三

  2019, Gastroenterological Endoscopy (Web), 61(Supplement1) (Supplement1)


• 肛門管切開を伴う内視鏡的粘膜下層剥離術(ESD)の術後狭窄の検討

  迫智也, 中野佳子, 豊永高史, 豊永高史, 田中心和, 鷹尾俊逹, 森田圭紀, 梅垣英次, 児玉裕三

  2019, Gastroenterological Endoscopy (Web), 61(Supplement1) (Supplement1)


• 当院で胃ESD後にPGAシートを貼付した16症例の検討

  阪口博哉, 鷹尾俊達, 森田圭紀, 児玉裕三

  2019, Gastroenterological Endoscopy (Web), 61(Supplement1) (Supplement1)


• 十二指腸病変に対する腹腔鏡内視鏡合同手術の検討

  山本将士, 金治新悟, 森田圭紀, 森田圭紀, 掛地吉弘

  日本消化器病学会-近畿支部, 2019, 日本消化器病学会近畿支部例会プログラム・抄録集, 111th, 51 - 51, Japanese


• Endoscopic submucosal dissection in a patient with idiopathic mesenteric phlebosclerosis

  R. Schroder, Yoshiko Nakano, T. Toyonaga, H. Abe, R. Ariyoshi, S. Tanaka, T. Takao, Y. Morita, E. Umegaki, Y. Kodama

  2019, Acta Gastro-Enterologica Belgica, 82(2) (2), 341 - 342

  Report scientific journal


• 表在型非乳頭部十二指腸上皮性腫瘍に対する腹腔鏡内視鏡合同手術の検討(内視鏡医の立場から)

  迫智也, 森田圭紀, 森田圭紀, 金治新悟, 児玉裕三

  日本消化器病学会-近畿支部, 2019, 日本消化器病学会近畿支部例会プログラム・抄録集, 111th, 51 - 51, Japanese


• バルーン拡張術が有効であったPlummer-vinson症候群の一例

  津田一範, 田中心和, 阿部洋文, 若原ちか, 浦上聡, 朝治直紀, 松本慶, 池澤伸明, 賀来英俊, 阪口博哉, 迫智也, 鷹尾まど佳, 鷹尾俊達, 森田圭紀, 豊永高史, 児玉裕三

  日本消化器病学会-近畿支部, 2019, 日本消化器病学会近畿支部例会プログラム・抄録集, 111th, 109 - 109, Japanese


• 軟性持針器を用いた内視鏡的胃全層縫合術の開発

  阪口 博哉, 鷹尾 俊達, 森田 圭紀

  (一社)日本消化器内視鏡学会, Oct. 2018, Gastroenterological Endoscopy, 60(Suppl.2) (Suppl.2), 2141 - 2141, Japanese


• 新しい診断・治療モダリティへの挑戦(1) 炭酸ガスレーザーが切り拓く次世代の消化器内視鏡治療に向けての取り組み

  森田 圭紀, 有吉 隆佑, 野口 拓真, 間 久直, 日吉 勝海, 本郷 晃史, 岡上 吉秀, 粟津 邦男

  (NPO)日本レーザー医学会, Sep. 2018, 日本レーザー医学会誌, 39(3) (3), 205 - 205, Japanese


• 炭酸ガスレーザーを用いた内視鏡的粘膜下層剥離術におけるヒト大腸に対する安全性評価

  野口 拓真, 間 久直, 森田 圭紀, 粟津 邦男

  (NPO)日本レーザー医学会, Sep. 2018, 日本レーザー医学会誌, 39(3) (3), 273 - 273, Japanese


• 【高リスク患者の内視鏡】 上部消化管 抗血栓薬を中止できない患者に対するESDの注意点と対策

  阪口博哉, 豊永高史, 中野佳子, 有吉隆佑, 阿部洋文, 田中心和, 鷹尾俊達, Morita Yoshinori, 梅垣英次

  (株)東京医学社, Jul. 2018, 消化器内視鏡, 30(7) (7), 859 - 867, Japanese

  Introduction scientific journal


• Final analysis of single-arm confirmatory study of diagnostic endoscopic resection(ER) plus selective chemoradiotherapy (CRT) for stage I esophageal squamous cell carcinoma (ESCC): JCOG0508.

  Keiko Minashi, Keiji Nihei, Gakuto Ogawa, Kohei Takizawa, Tomonori Yano, Yusuke Amanuma, Tomohiro Tsuchida, Hiroyuki Ono, Toshiro Iizuka, Satoki Shichijyo, Ichiro Oda, Yoshinori Morita, Masahiro Tajika, Junko Fujiwara, Yoshinobu Yamamoto, Chikatoshi Katada, Shinichiro Hori, Hisashi Doyama, Haruhiko Fukuda, Manabu Muto

  May 2018, JOURNAL OF CLINICAL ONCOLOGY, 36(15) (15), English

  Summary international conference


• 表在性非乳頭部十二指腸上皮性腫瘍に対する治療戦略 表在性非乳頭部十二指腸上皮性腫瘍に対する腹腔鏡内視鏡合同手術(D-LECS)の妥当性の検討

  迫 智也, 森田 圭紀, 豊永 高史

  (一社)日本消化器内視鏡学会, Apr. 2018, Gastroenterological Endoscopy, 60(Suppl.1) (Suppl.1), 544 - 544, Japanese


• Double scope法による軟性持針器を用いた内視鏡的胃全層縫合術の開発

  阪口 博哉, 鷹尾 俊達, 森田 圭紀

  (一社)日本消化器内視鏡学会, Apr. 2018, Gastroenterological Endoscopy, 60(Suppl.1) (Suppl.1), 691 - 691, Japanese


• フィブリン糊とポリグリコール酸シートを用いた被覆法における反重力面へのシート貼付に関する基礎的検討

  竹川 佳孝, 鷹尾 俊達, 小原 佳子, 阪口 博哉, 森田 圭紀

  (一社)日本消化器内視鏡学会, Apr. 2018, Gastroenterological Endoscopy, 60(Suppl.1) (Suppl.1), 869 - 869, Japanese


• ポリグリコール酸シート運搬・貼付時のエンベロープ型デリバリーシステムの有用性に関する検討

  鷹尾 俊達, 竹川 佳孝, 小原 佳子, 阪口 博哉, 森田 圭紀

  (一社)日本消化器内視鏡学会, Apr. 2018, Gastroenterological Endoscopy, 60(Suppl.1) (Suppl.1), 870 - 870, Japanese


• 【ここまできた胃・十二指腸ESD-現状と今後の展望】 安全に治療を行うためのセデーションとリスクマネジメント

  有吉隆佑, 豊永高史, Morita Yoshinori, 万井真理子, 阪口博哉, 阿部洋文, 中野佳子, 田中心和, 石田司, 梅垣英次

  (株)東京医学社, Apr. 2018, 消化器内視鏡, 30(4) (4), 433 - 439, Japanese

  Introduction scientific journal


• 胃前庭部内視鏡的粘膜下層剥離術後の通過障害に対する内視鏡的前庭部形成術

  中野 佳子, 豊永 高史, 森田 圭紀, 梅垣 英次

  (一社)日本胃癌学会, Mar. 2018, 日本胃癌学会総会記事, 90回, 577 - 577, Japanese


• 治療に難渋した残胃吻合部近傍の胃癌の一例

  田中 心和, 森田 圭紀, 豊永 高史, 梅垣 英次

  (一社)日本胃癌学会, Mar. 2018, 日本胃癌学会総会記事, 90回, 578 - 578, Japanese


• 当院における表在性非乳頭部十二指腸腫瘍に対するLECSの治療成績

  森田 圭紀, 金治 新悟, 河原 史明, 豊永 高史, 山本 将士, 鈴木 知志, 掛地 吉弘

  (一社)日本消化管学会, Feb. 2018, 日本消化管学会雑誌, 2(Suppl.) (Suppl.), 216 - 216, Japanese


• Quantitative evaluation of the safety of mucosal incision and submucosal dissection for colon during endoscopic submucosal dissection using carbon dioxide laser

  Takuma Noguchi, Norihiro Honda, Hisanao Hazama, Yoshinori Morita, Kunio Awazu

  SPIE, 2018, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 10492, English


• 指導施設における女性内視鏡医のキャリアサポート体制に関するアンケート調査結果

  原田 直彦, 中村 真一, 平岡 佐規子, 白鳥 敬子, 春間 賢, 河合 隆, 森田 圭紀, 横井 千寿, 南 ひとみ, 附置研究会「女性内視鏡医のキャリアサポートを目指した教育研修体制確立に関する研究会」

  (一社)日本消化器内視鏡学会, Nov. 2017, Gastroenterological Endoscopy, 59(11) (11), 2640 - 2646, Japanese


• 十二指腸腫瘍に対する腹腔鏡内視鏡合同手術の手術成績の検討

  永田 真知子, 金治 新悟, 森田 圭紀, 河原 史明, 音羽 泰則, 山本 将士, 松田 佳子, 押切 太郎, 中村 哲, 豊永 高史, 鈴木 知志, 東 健, 掛地 吉弘

  (一社)日本消化器外科学会, Oct. 2017, 日本消化器外科学会雑誌, 50(Suppl.2) (Suppl.2), 318 - 318, Japanese


• レーザーが開拓する新しい消化器疾患の診断と治療 CO2レーザーによる次世代の大腸ESD技術の開発

  森田 圭紀, 有吉 隆佑, 本多 典広, 間 久直, 粟津 邦男

  (NPO)日本レーザー医学会, Oct. 2017, 日本レーザー医学会誌, 38(3) (3), 260 - 260, Japanese


• CO2レーザーによる次世代の消化器内視鏡治療技術の開発

  有吉 隆佑, 森田 圭紀

  (NPO)日本レーザー医学会, Oct. 2017, 日本レーザー医学会誌, 38(3) (3), 314 - 314, Japanese


• Innovative therapeutic endoscopy 大腸ESD/EMRの課題と将来展望 CO2レーザーによる次世代の大腸ESD技術の開発

  森田 圭紀, 有吉 隆佑, 東 健

  (一財)日本消化器病学会, Sep. 2017, 日本消化器病学会雑誌, 114(臨増大会) (臨増大会), A558 - A558, Japanese


• 十二指腸非乳頭部腫瘍をどうする? 表在性非乳頭部十二指腸上皮性腫瘍(SNADET)に対する治療法の選択

  河原 史明, 森田 圭紀, 豊永 高史

  (一財)日本消化器病学会, Sep. 2017, 日本消化器病学会雑誌, 114(臨増大会) (臨増大会), A628 - A628, Japanese


• 大腸ESD/EMRの課題と将来展望 CO2レーザーによる次世代の大腸ESD技術の開発

  森田 圭紀, 有吉 隆佑, 東 健

  (一社)日本消化器内視鏡学会, Sep. 2017, Gastroenterological Endoscopy, 59(Suppl.2) (Suppl.2), 2020 - 2020, Japanese


• 十二指腸非乳頭部腫瘍をどうする? 表在性非乳頭部十二指腸上皮性腫瘍(SNADET)に対する治療法の選択

  河原 史明, 森田 圭紀, 豊永 高史

  (一社)日本消化器内視鏡学会, Sep. 2017, Gastroenterological Endoscopy, 59(Suppl.2) (Suppl.2), 2072 - 2072, Japanese


• 頸部食道に進展した表在型食道腫瘍に対するESDの治療経過

  有吉 隆佑, 豊永 高史, 小原 佳子, 河原 史明, 田中 心和, 森田 圭紀, 梅垣 英次, 東 健

  (NPO)日本食道学会, Jun. 2017, 日本食道学会学術集会プログラム・抄録集, 71回, O1 - 5, Japanese


• 当院におけるJackhammer esophagus 9症例の検討

  阿部 洋文, 田中 心和, 河原 史明, 小原 佳子, 石田 司, 森田 圭紀, 豊永 高史, 梅垣 英次, 東 健

  (NPO)日本食道学会, Jun. 2017, 日本食道学会学術集会プログラム・抄録集, 71回, P39 - 4, Japanese


• 【消化管癌ESDの最前線】 大腸ESDの現状と限界例への挑戦

  豊永高史, Morita Yoshinori, Umegaki Eiji

  (一財)日本消化器病学会, Jun. 2017, 日本消化器病学会雑誌, 114(6) (6), 989 - 1000, Japanese

  Introduction scientific journal


• Aberrant Polypoid Nodule Scar After Gastric Endoscopic Submucosal Dissection: Results From a Multicenter Study

  Vitor N. Arantes, Noriya Uedo, Yoshinori Morita, Takashi Toyonaga, Yoshiko Ohara, Moises S. Pedrosa, Yasuhiko Tomita, Ichiro Oda, Yutaka Saito

  May 2017, GASTROINTESTINAL ENDOSCOPY, 85(5) (5), AB451 - AB452, English

  Summary international conference


• Utility and Usefulness of Gastric Endscopic Submucosal Dissection (ESD) for Elderly Patients Older Than 80 Years Old

  Hiroya Sakaguchi, Yoshiko Ohara, Takashi Toyonaga, Kouki Matsuoka, Tomoya Sako, Ryusuke Ariyoshi, Hirofumi Abe, Fumiaki Kawara, Shinwa Tanaka, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma

  May 2017, GASTROINTESTINAL ENDOSCOPY, 85(5) (5), AB321 - AB321, English

  Summary international conference


• Innovative Therapeutic Endoscopy 上部消化管疾患 CO2レーザーによる次世代のESD技術の開発

  森田 圭紀, 有吉 隆佑, 東 健

  (一社)日本消化器内視鏡学会, Apr. 2017, Gastroenterological Endoscopy, 59(Suppl.1) (Suppl.1), 746 - 746, Japanese


• ハンズオンセミナーを検証する 当院における内視鏡トレーニングセンターの活動 ESDの安全かつ効率的な普及を目指して

  森田 圭紀

  (一社)日本消化器内視鏡学会, Apr. 2017, Gastroenterological Endoscopy, 59(Suppl.1) (Suppl.1), 812 - 812, Japanese


• 十二指腸非乳頭部腫瘍の内視鏡診断と治療 当院における表在性非乳頭部十二指腸上皮性腫瘍(SNADET)の治療法に関する検討

  河原 史明, 森田 圭紀, 豊永 高史

  (一社)日本消化器内視鏡学会, Apr. 2017, Gastroenterological Endoscopy, 59(Suppl.1) (Suppl.1), 889 - 889, Japanese


• ネオベールを使用した内視鏡治療症例の検討

  小原 佳子, 森田 圭紀, 石田 司, 田中 心和, 河原 史明, 豊永 高史

  (一社)日本消化器内視鏡学会, Apr. 2017, Gastroenterological Endoscopy, 59(Suppl.1) (Suppl.1), 1180 - 1180, Japanese


• 【ESD手技の標準化に向けて】 安全なESDのコツと偶発症の対処 大腸ESD 施術におけるクオリティコントロール

  小原佳子, 豊永高史, 石田司, Morita Yoshinori, Umegaki Eiji, Azuma Takeshi

  (株)日本メディカルセンター, Mar. 2017, 臨床消化器内科, 32(4) (4), 433 - 442, Japanese

  Introduction scientific journal


• 十二指腸腫瘍に対する腹腔鏡内視鏡合同手術の手術成績の検討

  永田真知子, 金治新悟, 森田圭紀, 河原史明, 音羽泰則, 山本将士, 松田佳子, 押切太郎, 中村哲, 豊永高史, 鈴木知志, 東健, 掛地吉弘

  2017, 日本消化器外科学会雑誌(Web), 50(Supplement2) (Supplement2)


• The experiences and the future tasks of the introduction of colorectal ESD in the Philippines

  Tsukasa Ishida, Juliet Lingat Gopez-Cervantes, Edgardo Mallari Bondoc, Yoshinori Morita, Takeshi Azuma

  Nov. 2016, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 31, 312 - 312, English

  Summary international conference


• 食道 食道がんに対する治療戦略 cSM食道癌に対するEMRとCRT併用治療の有効性に関する非ランダム化検証的試験 JCOG0508

  三梨 桂子, 飯塚 敏郎, 武藤 学, 二瓶 圭二, 矢野 友規, 江副 康正, 土田 知宏, 小野 裕之, 鼻岡 昇, 小田 一郎, 森田 圭紀, 滝沢 耕平, 水澤 純基, 片山 宏, 福田 治彦

  (一社)日本癌治療学会, Oct. 2016, 日本癌治療学会学術集会抄録集, 54回, MS20 - 1, Japanese


• 胃瘻造設における透明シースを使用した腹壁確認法

  吉崎 哲也, 梅垣 英次, 黒澤 学, 佐藤 悠, 安富 栄一郎, 大塚 崇史, 畑沢 友里, 川浦 由紀子, 小川 浩史, 小原 佳子, 河原 史明, 北村 泰明, 渡邉 大輔, 大井 充, 田中 心和, 石田 司, 森田 圭紀, 豊永 高史, 東 健

  (一社)日本消化器内視鏡学会, Oct. 2016, Gastroenterological Endoscopy, 58(Suppl.2) (Suppl.2), 2003 - 2003, Japanese


• 食道 食道がんに対する治療戦略 cSM食道癌に対するEMRとCRT併用治療の有効性に関する非ランダム化検証的試験 JCOG0508

  三梨 桂子, 飯塚 敏郎, 武藤 学, 二瓶 圭二, 矢野 友規, 江副 康正, 土田 知宏, 小野 裕之, 鼻岡 昇, 小田 一郎, 森田 圭紀, 滝沢 耕平, 水澤 純基, 片山 宏, 福田 治彦

  (一社)日本癌治療学会, Oct. 2016, 日本癌治療学会学術集会抄録集, 54回, MS20 - 1, Japanese


• 正しいレーザー治療の発展に必要なもの レーザー治療におけるEBM CO2レーザーによる次世代の消化器内視鏡治療技術の開発 早期消化管がんに対する安全で容易なESDを目指して

  森田 圭紀, 有吉 隆佑, 東 健, 石井 克典, 間 久直, 粟津 邦男, 岡上 吉秀

  (NPO)日本レーザー医学会, Sep. 2016, 日本レーザー医学会誌, 37(3) (3), 332 - 332, Japanese


• cT1b食道表在癌の治療 内視鏡治療先行の妥当性について

  池田 篤紀, 田中 心和, 森田 圭紀, 豊永 高史, 江島 泰生, 中村 哲, 横崎 宏

  (NPO)日本食道学会, Jul. 2016, 日本食道学会学術集会プログラム・抄録集, 70回, 188 - 188, Japanese


• 当院における大腸ESD穿孔後の外科的治療の検討

  前原 律子, 山下 公大, 金光 聖哲, 角 泰雄, 中村 哲, 森田 圭紀, 田中 心和, 豊永 高志, 鈴木 知志, 掛地 吉弘

  (一社)日本消化器外科学会, Jul. 2016, 日本消化器外科学会総会, 71回, P1 - 4, Japanese


• Clinical Outcomes of Endoscopic Submucosal Dissection for Superficial Neoplasms in Cervical Esophagus

  Ryusuke Ariyoshi, Takashi Toyonaga, Yoshiko Ohara, Tetsuya Yoshizaki, Fumiaki Kawara, Yasuaki Kitamura, Shinwa Tanaka, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma

  May 2016, GASTROINTESTINAL ENDOSCOPY, 83(5) (5), AB574 - AB574, English

  Summary international conference


• Efficacy of combined endoscopic resection and chemoradiotherapy for clinical stage I esophageal squamous cell carcinoma (ESCC): A single-arm confirmatory study (JCOG0508)

  Manabu Muto, Keiko Minashi, Keiji Nihei, Junki Mizusawa, Tomonori Yano, Yasumasa Ezoe, Tomohiro Tsuchida, Hiroyuki Ono, Toshiro Iizuka, Noboru Hanaoka, Ichiro Oda, Yoshinori Morita, Masahiro Tajika, Junko Fujiwara, Chikatoshi Katada, Shinichiro Hori, Haruhiko Fukuda, Kohei Takizawa

  May 2016, JOURNAL OF CLINICAL ONCOLOGY, 34(15) (15), English

  Summary international conference


• Feasibility of Near Focus View With Narrow Band Image (GIFHQ-290) for Estimating Horizontal Extension of Early Gastric Cancer

  Hyung Hun Kim, Eiji Umegaki, Takashi Toyonaga, Yoshinori Morita, Takeshi Azuma

  May 2016, GASTROINTESTINAL ENDOSCOPY, 83(5) (5), AB461 - AB461, English

  Summary international conference


• The Usefulness of a Novel Slim Type Flush Knife-BT Compared to the Conventional Flush Knife-BT

  Yoshiko Ohara, Takashi Toyonaga, Shinwa Tanaka, Tsukasa Ishida, Ryusuke Ariyoshi, Hirofumi Abe, Tetsuya Yoshizaki, Fumiaki Kawara, Yasuaki Kitamura, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma

  May 2016, GASTROINTESTINAL ENDOSCOPY, 83(5) (5), AB450 - AB450, English

  Summary international conference


• Feasibility and Safety of Endoscopic Submucosal Dissection for Lower Rectal Tumors With Hemorrhoids

  Shinwa Tanaka, Takashi Toyonaga, Yoshinori Morita, Tsukasa Ishida, Namiko Hoshi, Yoshiko Ohara, Tetsuya Yoshizaki, Fumiaki Kawara, Eiji Umegaki, Takeshi Azuma

  May 2016, GASTROINTESTINAL ENDOSCOPY, 83(5) (5), AB432 - AB432, English

  Summary international conference


• Development of Novel Method for colorectal Endoscopic Submucosal Dissection using Carbon Dioxide Laser

  Yoshinori Morita, Tetsuya Yoshizaki, Ryusuke Ariyoshi, Takeshi Azuma

  May 2016, GASTROINTESTINAL ENDOSCOPY, 83(5) (5), AB512 - AB513, English

  Summary international conference


• 内視鏡手技の解説 臨床のコツとテクニック 「Swanblade」を用いたESDのコツとピットフォール

  Morita Yoshinori

  (株)メディカルレビュー社, May 2016, 胃がんperspective, 8(4) (4), 274 - 279, Japanese

  Introduction scientific journal


• 大腸LSTの内視鏡治療 進歩と限界 痔核を合併した直腸LSTに対するESDの安全性・有効性とESD後の痔核の臨床経過の検討

  田中 心和, 豊永 高史, 森田 圭紀

  (一社)日本消化器内視鏡学会, Apr. 2016, Gastroenterological Endoscopy, 58(Suppl.1) (Suppl.1), 485 - 485, Japanese


• 上部消化管EMR/ESDの課題克服と新たな展開 表在性非乳頭部十二指腸上皮性腫瘍(SNADET)の治療方針に関する検討 EMR、ESD、LECS

  河原 史明, 森田 圭紀, 豊永 高史

  (一社)日本消化器内視鏡学会, Apr. 2016, Gastroenterological Endoscopy, 58(Suppl.1) (Suppl.1), 601 - 601, Japanese


• 上部消化管EMR/ESDの課題克服と新たな展開 CO2レーザーによる次世代のESD技術の開発

  森田 圭紀, 東 健

  (一社)日本消化器内視鏡学会, Apr. 2016, Gastroenterological Endoscopy, 58(Suppl.1) (Suppl.1), 604 - 604, Japanese


• CO2レーザーを用いたESD新規デバイスの安全性、有用性の検討

  吉崎 哲也, 森田 圭紀, 東 健

  (一社)日本消化器内視鏡学会, Apr. 2016, Gastroenterological Endoscopy, 58(Suppl.1) (Suppl.1), 634 - 634, Japanese


• 胃前庭部内視鏡的粘膜下層剥離術後の通過障害に対する内視鏡的前庭部形成術

  小原 佳子, 豊永 高史, 田邊 昭子, 馬場 慎一, 滝原 浩守, 井上 太郎, 尾野 亘, 田中 心和, 森田 圭紀, 梅垣 英次, 東 健

  (一社)日本消化器内視鏡学会, Apr. 2016, Gastroenterological Endoscopy, 58(Suppl.1) (Suppl.1), 635 - 635, Japanese


• 虫垂近傍の腫瘍性病変に対する内視鏡的粘膜下層剥離術の安全性および有用性

  小原 佳子, 豊永 高史, 壷内 栄治, 滝原 浩守, 馬場 慎一, 吉崎 哲也, 河原 史明, 田中 心和, 石田 司, 森田 圭紀, 梅垣 英次, 東 健

  (一社)日本消化器内視鏡学会, Apr. 2016, Gastroenterological Endoscopy, 58(Suppl.1) (Suppl.1), 671 - 671, Japanese


• 新ガイドライン導入後の抗血栓薬常用者における胃ESDの後出血リスクの検討

  有吉 隆佑, 森田 圭紀, 阿部 洋文, 吉崎 哲也, 小原 佳子, 河原 史明, 北村 泰明, 田中 心和, 石田 司, 豊永 高史, 梅垣 英次, 東 健

  (一社)日本消化器内視鏡学会, Apr. 2016, Gastroenterological Endoscopy, 58(Suppl.1) (Suppl.1), 696 - 696, Japanese


• ESDにおけるForced凝固超低出力設定を用いた新vessel sealing法

  小原 佳子, 豊永 高史, 吉崎 哲也, 河原 史明, 田中 心和, 石田 司, 森田 圭紀, 梅垣 英次, 東 健

  (一社)日本消化器内視鏡学会, Sep. 2015, Gastroenterological Endoscopy, 57(Suppl.2) (Suppl.2), 2099 - 2099, Japanese


• 新しいガイドライン発表後の上部消化管内視鏡検査における抗血栓薬の取り扱い 兵庫県下17施設のアンケート結果より

  藤田 欣也, 藤田 幹夫, 金 よう民, 富田 寿彦, 蓮池 典明, 森田 圭紀, 笹子 美津留

  (株)診断と治療社, Aug. 2015, 診断と治療, 103(8) (8), 1111 - 1117, Japanese


• ESDにて診断し得たgastric carcinoma with lymphoid stromaの一例

  吉崎 哲也, 小原 佳子, 田中 心和, 石田 司, 森田 圭紀, 豊永 高史, 梅垣 英次, 久津見 弘, 東 健

  京都消化器医会, Jun. 2015, 京都消化器医会会報, (31) (31), 25 - 28, Japanese


• Development of Novel Method for Endoscopic Submucosal Dissection Using Carbon Dioxide LASER

  Yoshinori Morita, Tetsuya Yoshizaki, Takeshi Azuma

  May 2015, GASTROINTESTINAL ENDOSCOPY, 81(5) (5), AB451 - AB451, English

  Summary international conference


• Helicobacter pylori陽性早期胃癌に対する内視鏡的粘膜下層剥離術後の潰瘍治療 1W除菌+7wレバミピド投与群と8w PPI投与群との多施設共同前向き比較試験

  竹内 利寿, 上堂 文也, 竹内 洋司, 内藤 裕二, 八木 信明, 富永 和作, 町田 浩久, 玉田 尚, 森田 圭紀, 八隅 秀二郎, 山尾 純一, 井口 幹崇, 東 健, 樋口 和秀

  (一社)日本ヘリコバクター学会, May 2015, 日本ヘリコバクター学会誌, 17(1) (1), 2 - 7, Japanese


• 胃・十二指腸腫瘍に対するEMR/ESDの課題と将来展望 新型止血鉗子の止血能に関する前向き無作為化試験

  田中 心和, 豊永 高史, 森田 圭紀

  (一社)日本消化器内視鏡学会, Apr. 2015, Gastroenterological Endoscopy, 57(Suppl.1) (Suppl.1), 588 - 588, Japanese


• 直腸肛門部腫瘍の治療選択 内科と外科の接点 肛門管にかかる病変に対するESDの検討と戦略

  石田 司, 豊永 高史, 森田 圭紀

  (一社)日本消化器内視鏡学会, Apr. 2015, Gastroenterological Endoscopy, 57(Suppl.1) (Suppl.1), 596 - 596, Japanese


• 臨床応用に向けた次世代消化器内視鏡とその周辺機器開発の現況 CO2レーザーによる新しいESD技術の開発

  森田 圭紀, 吉崎 哲也, 東 健

  (一社)日本消化器内視鏡学会, Apr. 2015, Gastroenterological Endoscopy, 57(Suppl.1) (Suppl.1), 641 - 641, Japanese


• 当院における女性消化器内科医への支援体制について

  若原 ちか, 森田 圭紀, 東 健

  (一社)日本消化器内視鏡学会, Apr. 2015, Gastroenterological Endoscopy, 57(Suppl.1) (Suppl.1), 1005 - 1005, Japanese


• 早期胃癌ESDにおける私のこだわりの手技

  豊永 高史, 森田 圭紀, 梅垣 英次, 東 健

  (一社)日本胃癌学会, Mar. 2015, 日本胃癌学会総会記事, 87回, 164 - 164, Japanese


• 食道癌ESDの困難例、CRT後の局所再発も含めて

  森田 圭紀, 豊永 高史, 梅垣 英次

  (一財)日本消化器病学会, Mar. 2015, 日本消化器病学会雑誌, 112(臨増総会) (臨増総会), A276 - A276, Japanese


• 胃癌ESDの困難例、特に潰瘍合併例

  梅垣 英次, 森田 圭紀, 豊永 高史

  (一財)日本消化器病学会, Mar. 2015, 日本消化器病学会雑誌, 112(臨増総会) (臨増総会), A277 - A277, Japanese


• 大腸ESDの現状と今後の発展 回盲弁上に存在する大腸腫瘍に対するESDの検討

  吉崎 哲也, 森田 圭紀, 小原 佳子, 河原 史明, 渡邉 大輔, 田中 心和, 石田 司, 豊永 高史, 梅垣 英次, 東 健

  (社)日本大腸検査学会, Jan. 2015, 日本大腸検査学会雑誌, 31(2) (2), 100 - 100, Japanese


• Lobulated villous polyps with gastric mucin phenotype in the duodenal bulb: two case reports

  Fumiaki Kawara, Tetsuya Yoshizaki, Yoshiko Ohara, Shinwa Tanaka, Tsukasa Ishida, Yoshinori Morita, Takashi Toyonaga, Eiji Umegaki, Hiroshi Yokozaki, Takeshi Azuma

  Nov. 2014, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 29, 82 - 83, English

  Summary international conference


• Feasibility of endoscopic submucosal dissection for the treatment of colorectal neoplasms on ileocecal valve

  Tetsuya Yoshizaki, Takashi Toyonaga, Yoshiko Ohara, Fumiaki Kawara, Daisuke Watanabe, Shinwa Tanaka, Tsukasa Ishida, Namiko Hoshi, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma

  Nov. 2014, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 29, 44 - 44, English

  Summary international conference


• 消化器領域のレーザー CO2レーザーによる新しいESD技術の開発

  森田 圭紀, 吉崎 哲也, 東 健, 石井 克典, 間 久直, 粟津 邦男, 岡上 吉秀

  (NPO)日本レーザー医学会, Oct. 2014, 日本レーザー医学会誌, 35(3) (3), 326 - 326, Japanese


• ESD Update 手技とデバイスの進歩からみた新たな可能性は? 上部消化管 胃ESDにおける新型止血鉗子の開発と有用性の検討

  田中 心和, 豊永 高史, 森田 圭紀

  (一社)日本消化器内視鏡学会, Sep. 2014, Gastroenterological Endoscopy, 56(Suppl.2) (Suppl.2), 3001 - 3001, Japanese


• 胃粘膜下腫瘍に対する粘膜切開生検症例15例の検討

  河原 史明, 田中 心和, 吉崎 哲也, 小原 佳子, 石田 司, 森田 圭紀, 豊永 高史, 東 健

  (一社)日本消化器内視鏡学会, Sep. 2014, Gastroenterological Endoscopy, 56(Suppl.2) (Suppl.2), 3099 - 3099, Japanese


• 【スキルアップESD】 知っておきたい偶発症とそのマネージメント 出血の予防と出血時のマネージメント

  Morita Yoshinori, Toyonaga Takashi, 梅垣 英次, Azuma Takeshi

  (株)東京医学社, Sep. 2014, 消化器内視鏡, 26(9) (9), 1470 - 1474, Japanese

  Introduction commerce magazine


• cT1b食道表在癌の治療 内視鏡治療先行の妥当性について

  池田 篤紀, 吉崎 哲也, 奥野 達哉, 江島 泰男, 中村 哲, 森田 圭紀, 豊永 高史, 横崎 宏, 掛地 吉弘, 東 健

  (NPO)日本食道学会, Jul. 2014, 日本食道学会学術集会プログラム・抄録集, 68回, 84 - 84, Japanese


• 食道ESDによる食道穿孔に伴い意識障害で発症したSIADHの1例

  吉崎 哲也, 田中 心和, 池田 篤紀, 石田 司, 奥野 達哉, 森田 圭紀, 豊永 高史, 東 健

  (NPO)日本食道学会, Jul. 2014, 日本食道学会学術集会プログラム・抄録集, 68回, 170 - 170, Japanese


• 当院での表在型バレット食道癌の治療成績

  石田 司, 森田 圭紀, 吉崎 哲也, 田中 心和, 豊永 高史

  (NPO)日本食道学会, Jul. 2014, 日本食道学会学術集会プログラム・抄録集, 68回, 177 - 177, Japanese


• 回盲弁を含む切除が必要な大腸腫瘍に対するESDの検討

  吉崎 哲也, 田中 心和, 小原 佳子, 河原 史明, 渡邉 大輔, 石田 司, 池原 伸直, 森田 圭紀, 豊永 高史, 東 健

  (一社)日本消化器内視鏡学会, Apr. 2014, Gastroenterological Endoscopy, 56(Suppl.1) (Suppl.1), 1123 - 1123, Japanese


• 大腸ESDの適応と手技 5cm以上の病変に対する大腸ESDの安全性・有効性に関する検討

  田中 心和, 豊永 高史, 森田 圭紀

  (一社)日本消化器内視鏡学会, Apr. 2014, Gastroenterological Endoscopy, 56(Suppl.1) (Suppl.1), 876 - 876, Japanese


• 内視鏡修練のクオリティーコントロール 消化管 当院における内視鏡トレーニングセンターの活動 ESDの安全かつ効率的な普及を目指して

  森田 圭紀, 豊永 高史, 東 健

  (一社)日本消化器内視鏡学会, Apr. 2014, Gastroenterological Endoscopy, 56(Suppl.1) (Suppl.1), 1027 - 1027, Japanese


• 表在性大腸腫瘍の内視鏡治療後遺残再発に対する内視鏡的粘膜下層剥離術の検討

  小原 佳子, 田中 心和, 吉崎 哲也, 河原 史明, 石田 司, 池原 伸直, 森田 圭紀, 豊永 高史, 東 健

  (一社)日本消化器内視鏡学会, Apr. 2014, Gastroenterological Endoscopy, 56(Suppl.1) (Suppl.1), 1181 - 1181, Japanese


• 当院でのバレット食道表在癌の治療成績

  石田 司, 森田 圭紀, 豊永 高史, 田中 心和, 河原 史明, 小原 佳子, 吉崎 哲也, 掛地 吉弘, 横崎 宏, 東 健

  (一社)日本消化器内視鏡学会, Apr. 2014, Gastroenterological Endoscopy, 56(Suppl.1) (Suppl.1), 1210 - 1210, Japanese


• 【大腸側方発育型腫瘍(LST)-新たな時代へ】LSTに対するESD治療の基本とピットフォール ESDの基本手技

  石田 司, 豊永 高史, 吉崎 哲也, 小原 佳子, 河原 史明, 田中 心和, 森田 圭紀, 横崎 宏, 東 健

  (株)日本メディカルセンター, Jan. 2014, Intestine, 18(1) (1), 79 - 88, Japanese


• 食道癌の深達度診断における食道学会分類の有用性の検討

  吉崎 哲也, 田中 心和, 河原 史明, 石田 司, 池原 伸直, 森田 圭紀, 豊永 高史, 東 健

  (一社)日本消化器内視鏡学会, Sep. 2013, Gastroenterological Endoscopy, 55(Suppl.2) (Suppl.2), 2888 - 2888, Japanese


• 内視鏡的に切除した胃型粘液形質を発現する十二指腸高分化型管状腺癌の1例

  河原 史明, 田中 心和, 吉崎 哲也, 石田 司, 池原 伸直, Morita Yoshinori, 豊永 高史, 東 健

  (一社)日本消化器内視鏡学会, Sep. 2013, Gastroenterological Endoscopy, 55(Suppl.2) (Suppl.2), 2824 - 2824, Japanese

  Meeting report


• 治療困難病変に対する胃ESDの実際、工夫 潰瘍(UL)症例に対する当院での胃ESDの治療成績と戦略

  石田 司, Morita Yoshinori, 豊永 高史

  (一社)日本消化器内視鏡学会, Sep. 2013, Gastroenterological Endoscopy, 55(Suppl.2) (Suppl.2), 2727 - 2727, Japanese

  Meeting report


• 【治療に直結する大腸腫瘍診断のストラテジー】 大腸内視鏡検査における病変の拾い上げと見逃し

  池原 伸直, 渡邉 大輔, 吉崎 哲也, 河原 史明, 田中 心和, 大井 充, 吉江 哲郎, 小畑 大輔, Ishida Tsukasa, Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (株)東京医学社, Aug. 2013, 消化器内視鏡, 25(8) (8), 1107 - 1113, Japanese

  Introduction scientific journal


• 大腸ESD穿孔後の外科的治療の検討

  音羽 泰則, 山下 公大, 金光 聖哲, 角 泰雄, 鈴木 知志, 森田 圭紀, 田中 心和, 豊永 高史, 田中 賢一, 掛地 吉弘

  (一社)日本消化器外科学会, Jul. 2013, 日本消化器外科学会総会, 68回, P - 7, Japanese


• 膜性腎症合併早期胃がんに対するESD後、狭窄を来たし、外科的バイパス術を要した1例

  石田 司, Morita Yoshinori, 豊永 高史, 吉崎 哲也, 河原 史明, 坂井 文, 田中 心和, 東 健, 中村 哲, 掛地 吉弘

  (一社)日本消化器内視鏡学会, Apr. 2013, Gastroenterological Endoscopy, 55(Suppl.1) (Suppl.1), 1194 - 1194, Japanese

  Meeting report


• 当院での食道T1a-MM、T1b癌に対する内視鏡治療及び追加治療の戦略

  池田 篤紀, 奥野 達哉, Morita Yoshinori

  (一社)日本消化器内視鏡学会, Apr. 2013, Gastroenterological Endoscopy, 55(Suppl.1) (Suppl.1), 1164 - 1164, Japanese

  Meeting report


• 大腸ESDにおける偶発症を予防するための施策 大腸ESDにおける血管の太さに応じた血管処理の工夫

  田中 心和, 豊永 高史, Morita Yoshinori

  (一社)日本消化器内視鏡学会, Apr. 2013, Gastroenterological Endoscopy, 55(Suppl.1) (Suppl.1), 1019 - 1019, Japanese

  Meeting report


• 食道静脈瘤を合併した表在型食道癌に対するESDの検討

  吉崎 哲也, Morita Yoshinori, 河原 史明, 坂井 文, 田中 心和, 石田 司, 池原 伸直, 豊永 高史, 東 健

  (一社)日本消化器内視鏡学会, Apr. 2013, Gastroenterological Endoscopy, 55(Suppl.1) (Suppl.1), 1050 - 1050, Japanese

  Meeting report


• 食道ESDにおける偶発症とその対策 当院での食道ESDにおける偶発症とその対策

  Morita Yoshinori, 豊永 高史, 東 健

  (一社)日本消化器内視鏡学会, Apr. 2013, Gastroenterological Endoscopy, 55(Suppl.1) (Suppl.1), 1024 - 1024, Japanese

  Meeting report


• 【ひとりでも迷わない 上部消化管 治療内視鏡の極意-さあ、自信をもって始めてみましょう!-】 食道・胃ESDにおけるデバイスの使い分け

  Morita Yoshinori

  (株)総合医学社, Apr. 2013, 消化器内視鏡レクチャー, 1(4) (4), 764 - 769, Japanese

  Introduction commerce magazine


• Helicobacter pylori(Hp)除菌後胃がん症例からの検討

  堀 公行, 堀 宏成, 谷岡 康喜, 森田 圭紀, 鈴木 康之, 西上 隆之

  (一社)兵庫県医師会, Mar. 2013, 兵庫県医師会医学雑誌, 55(2) (2), 20 - 20, Japanese


• 【必修 大腸ESD】病変のサイズと部位に応じた基本戦略

  Toyonaga Takashi, Yokozaki Hiroshi, Tanaka Shinwa, Ishida Tsukasa, Morita Yoshinori, Azuma Takeshi

  Mar. 2013, 消化器内視鏡, 25(3) (3), 433 - 443, Japanese

  [Refereed][Invited]

  Introduction commerce magazine


• 【必修!大腸ESD】 病変のサイズと部位に応じた基本的治療戦略

  豊永 高史, 西野 栄世, 横崎 宏, 坂井 文, 吉崎 哲也, 河原 史朗, 小畑 大輔, 田中 心和, 石田 司, 中村 彰宏, 永田 充, 馬場 慎一, 長谷川 晶子, 滝原 浩守, 中野 利宏, 井上 太郎, 尾野 亘, Morita Yoshinori, Azuma Takeshi

  (株)東京医学社, Mar. 2013, 消化器内視鏡, 25(3) (3), 433 - 443, Japanese

  Introduction scientific journal


• 食道表在癌に対するESD α療法の治療成績 食道T1a-MM、T1b癌に対する内視鏡治療及び追加治療の検討

  池田 篤紀, 奥野 達哉, Morita Yoshinori

  (一財)日本消化器病学会, Feb. 2013, 日本消化器病学会雑誌, 110(臨増総会) (臨増総会), A40 - A40, Japanese

  Meeting report


• 【大腸ESDの適応と実際】 深達度からみた大腸ESDの実際と限界

  Toyonaga Takashi, Yokozaki Hiroshi, Tanaka Shinwa, Ishida Tsukasa, Morita Yoshinori, Azuma Takeshi

  (株)医学書院, Feb. 2013, 胃と腸, 48(2) (2), 145 - 154, Japanese

  Introduction scientific journal


• 【直腸LSTの診断と治療】 直腸LSTにおけるESDの有用性と安全性

  Morita Yoshinori, Toyonaga Takashi

  (有)科学評論社, Dec. 2012, 消化器内科, 55(6) (6), 744 - 748, Japanese

  Introduction commerce magazine


• 消化器科におけるレーザーの現状と新展開 CO2レーザーによる新しい消化器内視鏡治療技術の開発

  Morita Yoshinori, Azuma Takeshi

  (NPO)日本レーザー医学会, Oct. 2012, 日本レーザー医学会誌, 33(3) (3), 278 - 278, Japanese

  Introduction scientific journal


• 【消化器内視鏡トレーニングのあり方】 内視鏡トレーニングセンターの活動 ESDの安全確実な普及を目指して

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (株)日本メディカルセンター, Oct. 2012, 臨床消化器内科, 27(12) (12), 1563 - 1567, Japanese

  Introduction commerce magazine


• 【消化管救急】 疾患別にみたアプローチ 食道・胃静脈瘤、Mallory-Weiss syndrome

  Imanishi Tatsuya, Kakeji Yoshihiro, Morita Yoshinori

  (株)へるす出版, Oct. 2012, 救急医学, 36(11) (11), 1521 - 1526, Japanese

  Introduction commerce magazine


• 内視鏡治療後潰瘍に対する新たな縫縮方法(Endoscopic double-layered suturing method)の試み

  Tanaka Shinwa, Toyonaga Takashi, Ishida Tsukasa, Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Sep. 2012, Gastroenterological Endoscopy, 54(Suppl.2) (Suppl.2), 2915 - 2915, Japanese

  Introduction scientific journal


• 表層拡大型食道癌の診断と治療 当院での5cm以上表層拡大型食道癌の診断と治療戦略

  Ishida Tsukasa, Morita Yoshinori, Toyonaga Takashi

  (一社)日本消化器内視鏡学会, Apr. 2012, Gastroenterological Endoscopy, 54(Suppl.1) (Suppl.1), 915 - 915, Japanese

  Introduction scientific journal


• 内視鏡関連機器の開発と今後の展望 光吸収材とCO2レーザーによる新たなESD技術の開発

  Morita Yoshinori, Azuma Takeshi

  (一社)日本消化器内視鏡学会, Apr. 2012, Gastroenterological Endoscopy, 54(Suppl.1) (Suppl.1), 959 - 959, Japanese

  Introduction scientific journal


• 【レーザー医工学の進歩】 炭酸ガスレーザーを用いた内視鏡的粘膜下層剥離術

  Azuma Takeshi, Morita Yoshinori

  医歯薬出版(株), Feb. 2012, 医学のあゆみ, 240(6) (6), 523 - 526, Japanese

  Introduction scientific journal


• 【大腸SM癌に対する内視鏡治療の適応拡大】 主題 内視鏡治療手技における注意点 SM浸潤の可能性がある大腸癌に対するESD

  Toyonaga Takashi, Yokozaki Hiroshi, Tanaka Shinwa, Shiomi Hideyuki, Morita Yoshinori, Fujita Tsuyoshi, Azuma Takeshi

  (株)医学書院, Sep. 2011, 胃と腸, 46(10) (10), 1511 - 1519, Japanese

  Introduction scientific journal


• 【進むべきか引くべきか胃と大腸のSM癌-ESD時代の術前診断と治療戦略】 [大腸SM癌の診断と治療] SM浸潤の可能性のある大腸癌に対するESDの注意点

  Toyonaga Takashi, Yokozaki Hiroshi, Tanaka Shinwa, Shiomi Hideyuki, Morita Yoshinori, Fujita Tsuyoshi, Azuma Takeshi

  (株)東京医学社, May 2011, 消化器内視鏡, 23(5) (5), 951 - 959, Japanese

  Introduction scientific journal


• 【ESD・NOTESの将来展望 消化器内視鏡治療の最前線】 ESDの国際化に向けて必要な技術革新とは?

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (株)日本メディカルセンター, Feb. 2011, 臨床消化器内科, 26(3) (3), 299 - 303, Japanese

  Introduction scientific journal


• Modified fishing-line traction system in endoscopic submucosal dissection of large esophageal tumors

  S. K.K. Tsao, T. Toyonaga, Y. Morita, T. Fujita, T. Hayakumo, T. Azuma

  2011, Endoscopy, 43(2) (2), E119, English

  Report scientific journal


• CO2レーザーを用いた食道がんの内視鏡的粘膜下層剥離術の検討

  山田 啓一郎, 渡辺 聡, 石井 克典, 間 久直, 小畑 大輔, 森田 圭紀, 久津見 弘, 東 健, 粟津 邦男

  (NPO)日本レーザー医学会, Jan. 2011, 日本レーザー医学会誌, 31(4) (4), 463 - 463, Japanese


• 炭酸ガスレーザーと光吸収材を用いた内視鏡的粘膜下層剥離術の開発

  渡辺 聡, 山田 啓一郎, 石井 克典, 間 久直, 小畑 大輔, 森田 圭紀, 東 健, 粟津 邦男

  (NPO)日本レーザー医学会, Oct. 2010, 日本レーザー医学会誌, 31(3) (3), 335 - 335, Japanese


• 【表在癌の新しい対応】 早期胃癌に対する内視鏡的粘膜下層剥離術

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (株)医学書院, Oct. 2010, 耳鼻咽喉科・頭頸部外科, 82(11) (11), 751 - 755, Japanese

  Introduction scientific journal


• 【外科医のための大腸癌の診断と治療】 大腸癌の内視鏡治療 内視鏡的粘膜下層剥離術

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (株)医学書院, Oct. 2010, 臨床外科, 65(11) (11), 180 - 188, Japanese

  Introduction scientific journal


• 【これがNOTESだ】 NOTESに用いられる機器 NOTESの画像支援診断と電磁力学的手術ナビゲーションシステム

  Morita Yoshinori, Matsuoka Yuichiro, Yoshida Masaru, Toyonaga Takashi, Azuma Takeshi

  (株)東京医学社, Oct. 2010, 消化器内視鏡, 22(10) (10), 1691 - 1697, Japanese

  Introduction scientific journal


• 【救命・救急と内視鏡】 誤飲・誤嚥 消化管異物に対する内視鏡の役割 緊急性のある場合とない場合、小児例、小腸異物など

  Toyonaga Takashi, Morita Yoshinori, Azuma Takeshi

  (株)東京医学社, Sep. 2010, 消化器内視鏡, 22(9) (9), 1532 - 1537, Japanese

  Introduction scientific journal


• 【ロボット手術と最新の内視鏡外科手術】 ロボット手術、NOTESにおける実時間的手術ナビゲーション

  Morita Yoshinori, Matsuoka Yuichiro, Yoshida Masaru, Toyonaga Takashi, Azuma Takeshi

  (株)メディカルレビュー社, Sep. 2010, Surgery Frontier, 17(3) (3), 234 - 243, Japanese

  Introduction scientific journal


• 消化器がんにおける先進的アプローチ 早期消化管癌に対する内視鏡的粘膜下層剥離術(Progressiove approach for cancer of the digestive organs Endoscopic submucosal dissection for the treatment of GI epithelial neoplasm)

  豊永 高史, 森田 圭紀, 東 健

  日本癌学会, Aug. 2010, 日本癌学会総会記事, 69回, 72 - 72, English


• 早期胃癌に対する内視鏡的粘膜切除術におけるHelicobacter pylori除菌療法に関する意識調査 近畿内視鏡治療研究会アンケート調査より

  梅垣 英次, 豊永 高史, 道田 知樹, 上堂 文也, 町田 浩久, 森田 圭紀, 近畿内視鏡治療研究会

  (株)ヴァンメディカル, Jun. 2010, 消化器の臨床, 13(3) (3), 335 - 339, Japanese


• Adherence to Lvidenced-Based Guideline for the Prescription of Nonsteroidal Anti-Inllammatory Drugs in Japanese Patients

  Hidetaka Tsumura, Tsuyoshi Fujita, Isamu Tamura, Yoshinori Morita, Tsuyoshi Sanuki, Masaru Yoshida, Takashi Toyonaga, Hidekazu Mukai, Hideto Inokuchi, Hiromu Kutsumi, Takeshi Azuma

  May 2010, GASTROENTEROLOGY, 138(5) (5), S634 - S634, English

  Summary international conference


• 【もう一歩進んだ経鼻内視鏡】 経鼻内視鏡の早期胃癌に対するESDへの応用

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (株)東京医学社, May 2010, 消化器内視鏡, 22(5) (5), 846 - 852, Japanese

  Introduction scientific journal


• Newly Developed Surface Coil for Endoluminal MRI, Depiction of Porcine Gastric Wall Layers and Vascular Architecture In Vivo Study

  Yoshinori Morita, Hayato Yoshinaka, Yuichiro Matsuoka, Shoko Fujiwara, Maki Sugimoto, Hiromu Kutsumi, Takeshi Azuma

  Apr. 2010, GASTROINTESTINAL ENDOSCOPY, 71(5) (5), AB207 - AB207, English

  Summary international conference


• Three Dimensional Image Overlay Navigation Using Magnetic Endoscope Detection System for NOTES (R) and SILS

  Maki Sugimoto, Yoshinori Morita, Tsuyoshi Sanuki, Hiromu Kutsumi, Takeshi Azuma

  Apr. 2010, GASTROINTESTINAL ENDOSCOPY, 71(5) (5), AB318 - AB318, English

  Summary international conference


• 【やっぱり大切、基本手技】 高周波電流と電気手術器

  Toyonaga Takashi, Morita Yoshinori, Azuma Takeshi

  (株)東京医学社, Apr. 2010, 消化器内視鏡, 22(4) (4), 436 - 444, Japanese

  Introduction scientific journal


• 【大腸ESDとEMRのすみ分け】 ESDの必要性と手技のコツ/ピットフォール 手技のコツとピットフォール

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (株)日本メディカルセンター, Mar. 2010, Intestine, 14(2) (2), 176 - 180, Japanese

  Introduction scientific journal


• 【大腸だってESD】 大腸ESDの適応

  Morita Yoshinori, Toyonaga Takashi, Azuma Takeshi

  (株)東京医学社, Feb. 2010, 消化器内視鏡, 22(2) (2), 177 - 182, Japanese

  Introduction scientific journal


• 内視鏡の読み方 ESD術前の側方範囲診断にNBI拡大観察および酢酸・インジゴカルミンサンドイッチ法が有用であった表層拡大型胃高分化腺癌の1例

  小畑 大輔, 豊永 高史, 若原 ちか, 藤原 昌子, 田中 心和, 増田 充弘, 万井 真理子, 森田 圭紀, 久津見 弘, 東 健

  (株)日本メディカルセンター, Nov. 2009, 臨床消化器内科, 24(13) (13), 1745 - 1749, Japanese


• 【胃癌の治療 最近の考え方と治療の実際】胃癌に対する内視鏡治療 ESD

  豊永 高史, 西野 栄世, 森田 圭紀, 東 健

  (株)へるす出版, Sep. 2009, 消化器外科, 32(10) (10), 1561 - 1576, Japanese


• 手技の解説 大腸ESDのコツ

  豊永 高史, 森田 圭紀, 東 健

  (一社)日本消化器内視鏡学会, Sep. 2009, Gastroenterological Endoscopy, 51(9) (9), 2480 - 2497, Japanese


• 食道癌 T1aMM〜T1bに対する治療戦略 当院での食道表在癌の内科治療と外科治療の治療成績の比較について

  池田 篤紀, 奥野 達哉, 藤島 佳未, 森田 圭紀, 中村 哲, 西村 英輝, 佐々木 良平, 田村 孝雄, 黒田 大介, 豊永 高史, 久津見 弘, 東 健

  (一社)日本癌治療学会, Sep. 2009, 日本癌治療学会誌, 44(2) (2), 325 - 325, Japanese


• 【どうする大腸腫瘍】大腸ESDの実際 大腸ESDの進歩 安全性を考慮した最新テクニック

  田中 敏雄, 森田 圭紀, 豊永 高史, 東 健

  (株)東京医学社, Sep. 2009, 消化器内視鏡, 21(9) (9), 1437 - 1441, Japanese


• 消化管・肝胆膵ベッドサイドイメージング フリーソフトウェアOsiriXによる遠隔医療とテレメンタリング

  杉本 真樹, 森田 圭紀, 佐貫 毅, 田中 敏雄, 三木 章, 吉田 志栄, 万井 真理子, 奥野 達哉, 矢野 嘉彦, 吉田 優, 松岡 雄一郎, 瀬尾 靖, 藤田 剛, 豊永 高史, 久津見 弘, 熊本 悦子, 東 健, 片倉 康喜

  (株)へるす出版, Aug. 2009, 消化器外科, 32(9) (9), 1499 - 1505, Japanese


• 消化管・肝胆膵ベッドサイドイメージング フリーソフトウェアOsiriXによるPACSeラーニング

  杉本 真樹, 森田 圭紀, 佐貫 毅, 田中 敏雄, 三木 章, 吉田 志栄, 万井 真理子, 奥野 達哉, 矢野 嘉彦, 吉田 優, 松岡 雄一郎, 瀬尾 靖, 藤田 剛, 豊永 高史, 久津見 弘, 熊本 悦子, 東 健

  (株)へるす出版, Jul. 2009, 消化器外科, 32(8) (8), 1371 - 1379, Japanese


• 【Advanced Therapeutic Endoscopy】胃ESD困難例の対処法

  豊永 高史, 吉村 兼, 万井 真理子, 佐貫 毅, 森田 圭紀, 久津見 弘, 東 健

  (株)東京医学社, Jun. 2009, 消化器内視鏡, 21(6) (6), 873 - 878, Japanese


• 食道癌ESD後非治癒切除症例に対する手術症例の検討

  中村 哲, 黒田 大介, 山下 広大, 今西 達也, 鈴木 知志, 高瀬 至郎, 神垣 隆, 森田 圭紀, 豊永 高史, 黒田 嘉和

  (NPO)日本食道学会, Jun. 2009, 日本食道学会学術集会プログラム・抄録集, 63回, 183 - 183, Japanese


• 当院における大腸IIcの検討

  吉田 志栄, 森田 圭紀, 鎮西 亮, 田中 敏雄, 矢野 嘉彦, 佐貫 毅, 吉田 優, 瀬尾 靖, 豊永 高史, 久津見 弘, 井口 秀人, 東 健

  (一社)日本大腸肛門病学会, May 2009, 日本大腸肛門病学会雑誌, 62(5) (5), 355 - 355, Japanese


• Rebamipide Combined with PPI Enhances the Healing Process of Post-ESD Ulcer; A Randomized Prospective Study

  Shoko Fujiwara, Yoshinori Morita, Takashi Toyonaga, Tomoo Itoh, Masaru Yoshida, Hiromu Kutsumi, Hideto Inokuchi, Takeshi Azuma

  Apr. 2009, GASTROINTESTINAL ENDOSCOPY, 69(5) (5), AB178 - AB178, English

  Summary international conference


• Effectiveness of the Ball Tipped Flush Knife in Endoscopic Submucosal Dissection for the Treatment of GI Neoplasia

  Takashi Toyonaga, Mariko Man-I, Yoshinori Morita, Hiromu Kutsumi, Hideto Inokuchi, Takeshi Azuma

  Apr. 2009, GASTROINTESTINAL ENDOSCOPY, 69(5) (5), AB263 - AB263, English

  Summary international conference


• Long-Term Results of Endoscopic Submucosal Dissection for Early-Stage Gastrointestinal Tumors

  Mariko Man-I, Takashi Toyonaga, Yoshinori Morita, Hideto Inokuchi, Hiromu Kutsumi, Takeshi Azuma

  Apr. 2009, GASTROINTESTINAL ENDOSCOPY, 69(5) (5), AB133 - AB133, English

  Summary international conference


• 【食道扁平上皮癌に対するESDの適応と実際】Flushナイフによる食道ESD

  豊永 高史, 万井 真理子, 森田 圭紀, 佐貫 毅, 吉田 優, 久津見 弘, 井口 秀人, 東 健

  (株)医学書院, Mar. 2009, 胃と腸, 44(3) (3), 378 - 383, Japanese


• 当院におけるERCP後膵炎の現状

  吉田 志栄, 久津見 弘, 船津 英司, 佐貫 毅, 塩見 英之, 信谷 健太郎, 増田 充弘, 森田 圭紀, 矢野 嘉彦, 吉田 優, 瀬尾 靖, 豊永 高史, 井口 秀人, 東 健

  (一財)日本消化器病学会, Mar. 2009, 日本消化器病学会雑誌, 106(臨増総会) (臨増総会), A244 - A244, Japanese


• Role of Fc Receptors as a therapeutic target.

  Atsuhiro Masuda, Masaru Yoshida, Hideyuki Shiomi, Yoshinori Morita, Hiromu Kutsumi, Hideto Inokuchi, Shigeto Mizuno, Akira Nakamura, Toshiyuki Takai, Richard S Blumberg, Takeshi Azuma

  It has been forty years since the discovery of Fc Receptors and their function. Fc Receptors include the IgG receptors (FcgammaR), high-affinity IgE receptor (FcepsilonRI), IgA and IgA/IgM receptors, and neonatal Fc receptor for IgG (FcRn). In particular, the FcgammaRs have been well known to play an important role in many biologic processes including those associated with the response to infection and cancer as well as in the pathogenesis of immune-mediated diseases. Both positive and negative regulatory function has ascribed to Fc receptors and FcgammaRs in particular which serve to establish a threshold for immune cell activation. In other cases, Fc receptors such as FcRn possess a novel structure and function by playing a major role in the transport of IgG across polarized epithelial barriers at mucosal surfaces and in the regulation of IgG half-life. These diverse functions highlight the potential effectiveness of targeting Fc receptors for therapeutic purposes. This review summarizes new information available in the therapeutic applications of this biology.

  Mar. 2009, Inflammation & allergy drug targets, 8(1) (1), 80 - 6, English, International magazine

  [Refereed]


• A Study on QOL Improvement in Hospital Using Head Mounted Display

  GOMI YUICHI, MAN-I MARIKO, MORITA YOSHINORI, TERADA TSUTOMU, AZUMA TAKESHI, TSUKAMOTO MASAHIKO

  The entertainment for patients in hospital is strictly limited because of remedial limitations and look at privacy compared with that at home. However, it is important to provide an environment that the patients enjoy entertainment without concerning for reducing the physical pain and tedium of patients in hospital. In this paper, we investigate the effect of offering video contents with HMD (Head Mounted Display) to improve QOL (Quality Of Life). The result of experiment clarified the effectiveness of browsing contents on HMD for relaxation of mental pain and tedium of patients in hospital.

  Information Processing Society of Japan (IPSJ), 19 Jan. 2009, IPSJ SIG technical reports, 2009(5) (5), 97 - 104, Japanese


• A Consideration of Using Head Mounted Display on Endoscopic Surgery

  GOMI YUICHI, MORITA YOSHINORI, TERADA TSUTOMU, AZUMA TAKESHI, TSUKAMOTO MASAHIKO

  ヒュ-マンインタフェ-ス学会, 06 Nov. 2008, Human Interface, 10(4) (4), 75 - 81, Japanese


• 胆管深部挿管困難例に対する膵管ステント併用プレカットの有用性、安全性に関する検討

  吉田 志栄, 久津見 弘, 松本 優子, 堀 順子, 増田 充弘, 塩見 英之, 信谷 健太郎, 森田 圭紀, 矢野 嘉彦, 吉田 優, 瀬尾 靖, 田村 孝雄, 豊永 高史, 井口 秀人, 東 健

  (一財)日本消化器病学会, Sep. 2008, 日本消化器病学会雑誌, 105(臨増大会) (臨増大会), A880 - A880, Japanese


• 当院におけるERCP後膵炎の現状と対策

  吉田 志栄, 久津見 弘, 松本 優子, 堀 順子, 増田 充弘, 塩見 英之, 信谷 健太郎, 森田 圭紀, 矢野 嘉彦, 吉田 優, 瀬尾 靖, 田村 孝雄, 豊永 高史, 井口 秀人, 東 健

  (一財)日本消化器病学会, Sep. 2008, 日本消化器病学会雑誌, 105(臨増大会) (臨増大会), A898 - A898, Japanese


• 【当直医のための消化器救急診療マニュアル】 上部消化管疾患が疑われる場合の検査・治療の進め方 消化管異物が疑われる場合の対応

  Toyonaga Takashi, Morita Yoshinori, Azuma Takeshi

  (株)東京医学社, Jun. 2008, 消化器内視鏡, 20(6) (6), 815 - 819, Japanese

  Introduction scientific journal


• 腸内細菌防御とFcγレセプター

  Yoshida Masaru, Masuda Atsuhiro, Morita Yoshinori, Azuma Takeshi

  (有)科学評論社, May 2008, 臨床免疫・アレルギー科, 49(5) (5), 599 - 605, Japanese

  Introduction scientific journal


• 【高齢者における内視鏡的粘膜下層剥離術(ESD)】 高齢者に対するESDの周術期管理

  Toyonaga Takashi, Morita Yoshinori, Azuma Takeshi

  (株)アークメディア, May 2008, 老年消化器病, 20(1) (1), 3 - 8, Japanese

  Introduction scientific journal


• The incidence of other malignancies in patients with intraductal papillary mucinous neoplasms of the pancreas: Emphasis on whole-body surveillance

  Ikuya Miki, Hiromu Kutsumi, Tetsuo Ajiki, Ippei Matsumoto, Shiei Yoshida, Yoshinori Morita, Takashi Toyonaga, Masaru Yoshida, Hideto Inokuchi, Shigeto Mizuno, Takeshi Azuma

  Apr. 2008, GASTROENTEROLOGY, 134(4) (4), A698 - A698, English

  Summary international conference


• 【最新の食道・胃腫瘍性病変の内視鏡治療 エキスパートからの提案】 胃癌 安全にできる内視鏡治療の工夫とコツ 私はこう行う 胃ESD Flushナイフをどう使うか

  Toyonaga Takashi, Morita Yoshinori

  (株)ヴァンメディカル, Apr. 2008, 消化器の臨床, 11(2) (2), 184 - 186, Japanese

  Introduction scientific journal


• 【胃癌のすべて】 胃癌の基礎 胃癌の分子生物学 Helicobacter pylori CagAと胃発癌

  Azuma Takeshi, Yoshida Masaru, Morita Yoshinori, Toyonaga Takashi

  (株)へるす出版, Apr. 2008, 消化器外科, 31(5) (5), 617 - 621, Japanese

  Introduction scientific journal


• 【ESD 食道・大腸への展開】大腸におけるESDのメリットと適応および治療成績

  豊永 高史, 廣岡 知臣, 尾野 亘, 西野 栄世, 万井 真理子, 森田 圭紀, 吉田 優, 久津見 弘, 井口 秀人, 東 健

  (株)東京医学社, Mar. 2008, 消化器内視鏡, 20(3) (3), 346 - 353, Japanese


• 当院で経験した膵管内乳頭粘液性腫瘍(IPMN)の他臓器癌の合併についての検討

  吉田 志栄, 三木 生也, 松本 逸平, 久津見 弘, 矢野 嘉彦, 森田 圭紀, 吉田 優, 瀬尾 靖, 田村 孝雄, 豊永 高史, 井口 秀人, 具 英成, 東 健

  (一財)日本消化器病学会, Mar. 2008, 日本消化器病学会雑誌, 105(臨増総会) (臨増総会), A260 - A260, Japanese


• A Consideration of Using Head Mounted Display on Endoscopic Surgery

  GOMI YUICHI, MORITA YOSHINORI, TERADA TSUTOMU, AZUMA TAKESHI, TSUKAMOTO MASAHIKO

  Endoscopic surgery is a technique that enables surgeons to resect lesions with minimum surgical invasion and offers patients little strain. As a result, it gathers attention in recent years. However, it requires the advanced techniques to perform operations considering various biological information at the same time such as heart rate, blood pressure and blood oxygen saturation level. In this paper, we propose an information presentation system that displays endoscopic images and biological information on Head Mounted Display (HMD) and enables the surgeon to switch over the images. We actually used the prototype system in a live seminar of endoscopic submucosal dissection. From the result, HMD can be used for reducing surgeons' burden in endoscopic surgeries.

  Information Processing Society of Japan (IPSJ), Mar. 2008, IPSJ SIG technical reports, 2008(106) (106), 75 - 81, Japanese


• 【ERCP関連手技をより安全に行うために】 プレカットによる胆管深部挿管 膵管ステント併用の有用性

  久津見 弘, 舩津 英司, 塩見 英之, 信谷 健太郎, 増田 充弘, 吉田 志栄, 松本 優子, 三木 生也, 森田 佳紀, 吉田 優, 豊永 高史, 八木 信明, 藤本 荘太郎, 井口 秀人, 東 健

  医学図書出版(株), Jan. 2008, 胆と膵, 29巻, 1号, pp. 39-44(1) (1), 39 - 44, Japanese


• ESDの実際 ESDにおける処置具の選び方・使い方 高周波発生装置・止血処置具

  Morita Yoshinori

  (株)ヴァンメディカル, Dec. 2007, 消化器の臨床, 10(6) (6), 647 - 652, Japanese

  Introduction scientific journal


• How long should endoscopic pancreatic stent be maintained?

  Reiko Akitake, Hiromu Kutsumi, Satoshi Ikezawa, Eiji Funatsu, Nobuaki Yagi, Sotaro Fujimoto, Yoshinori Morita, Masaru Yoshida, Takeshi Azuma, Hideo Inokuchi

  Oct. 2007, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 22, A144 - A144, English

  Summary international conference


• Relationship between gastric cancer and strain diversity of Helicobacter pylori in Asia

  Takeshi Azuma, Hiroshi Tanaka, Yoshinori Morita, Masaru Yoshida, Hiromu Kutsumi

  Oct. 2007, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 22, A53 - A53, English

  Summary international conference


• 【Helicobacter pylori感染と未分化型胃癌】分子生物学的見地から Helicobacter pylori感染は胃癌の組織型に関与するか

  東 健, 田中 擴址, 森田 圭紀, 吉田 優, 久津見 弘

  (株)先端医学社, Oct. 2007, Helicobacter Research, 11(5) (5), 443 - 447, Japanese


• 【分子メカニズムから探るIBDの病態と治療アプローチ】腸管免疫監視機構におけるIgGの役割とIBD

  塩見 英之, 吉田 優, 増田 充弘, 森田 圭紀, 久津見 弘, 井口 秀人, 東 健

  (株)先端医学社, Sep. 2007, IBD Research, 1(3) (3), 184 - 188, Japanese


• 【消化器薬の使い方Update】消化器疾患の薬物治療 薬剤起因性消化管粘膜傷害

  東 健, 森田 圭紀, 吉田 優, 久津見 弘, 井口 秀人

  (株)医学書院, Sep. 2007, Medicina, 44(9) (9), 1688 - 1691, Japanese


• マウスクローン病モデルを用いた不飽和脂肪酸由来生理的活性物質の有効性の検討

  石田 司, 吉田 優, 増田 充弘, 塩見 英之, 田中 擴址, 鎮西 亮, 高川 哲也, 森田 圭紀, 久津見 弘, 井口 秀人, 東 健

  (一財)日本消化器病学会, Sep. 2007, 日本消化器病学会雑誌, 104(臨増大会) (臨増大会), A621 - A621, Japanese


• 早期消化管癌(食道・胃・大腸)の内視鏡治療におけるトレーニングセンター兼医療機器開発センターの設立

  Morita Yoshinori

  (一社)神緑会, Aug. 2007, 神緑会学術誌, 23, 86 - 88, Japanese

  Introduction scientific journal


• Complications of endoscopic sphincterotomy for choledocholithiasis: Safety and benefits of pancreatic stent preplacement

  Hiromu Kutsumi, Eiji Funatsu, Yoshinori Morita, Masaru Yoshida, Hideto Inokuchi, Takeshi Azuma

  Jul. 2007, DIGESTIVE ENDOSCOPY, 19, S64 - S67, English


• 【消化器の炎症からの腫瘍】胃 H.pylori感染胃粘膜での発癌の機序

  東 健, 田中 擴址, 森田 圭紀, 吉田 優, 久津見 弘

  (株)日本メディカルセンター, May 2007, 臨床消化器内科, 22(7) (7), 808 - 814, Japanese


• 基礎研究の新たな方向性を解く 疾患解明Overview Helicobacter pylori感染と胃癌

  MORITA YOSHINORI, KUTSUMI HIROMU

  (株)羊土社, May 2007, 実験医学, 25(8) (8), 1254 - 1260, Japanese

  Introduction scientific journal


• Solvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, products, against 2,4,6-trinitorobenzene sulfonic acid-induced colitis in mice

  Tsukasa Ishida, Masaru Yoshida, Atsuhiro Masuda, Hideyuki Shiomi, Tetsuya Takagawa, Hiroshi Tanaka, Ryo Chinzei, Yoshinori Morita, Hiromu Kutsumi, Hideto Inokuchi, Makoto Arita, Charles N. Serhan, Takeshi Azuma

  Apr. 2007, GASTROENTEROLOGY, 132(4) (4), A560 - A560, English

  Summary international conference


• The new approach for the difficult cases in early gastric cancer treatment-development of double scope-ESD method

  Yoshinori Morita, Masanori Toyoda, Yuko Matsumoto, Masaru Yoshida, Takao Tamura, Hiromu Kutsumi, Hideto Inokuchi, Takeshi Azuma

  Apr. 2007, GASTROINTESTINAL ENDOSCOPY, 65(5) (5), AB92 - AB92, English

  Summary international conference


• Relationship of B-Raf mutation, morphology and apoptosis in early colorectal cancer

  Shiei Yoshida, Nobunao Ikehara, Nobuo Aoyama, Daisuke Shirasaka, Masanori Sakashita, Shuho Semba, Tadateru Hasuo, Ikuya Miki, Yoshinori Morita, Takao Tamura, Hiroshi Yokozaki, Takeshi Azuma

  Apr. 2007, GASTROENTEROLOGY, 132(4) (4), A382 - A383, English

  Summary international conference


• The role of FC gamma receptors in defending against Citrobacter rodentium infection

  Atsuhiro Masuda, Masaru Yoshida, Tetsuya Takagawa, Hideyuki Shiomi, Ryo Chinzei, Hiroshi Tanaka, Tsukasa Ishida, Yoshinori Morita, Hiromu Kutsumi, Hideto Inokuchi, Richard S. Blumberg, Takeshi Azuma

  Apr. 2007, GASTROENTEROLOGY, 132(4) (4), A702 - A703, English

  Summary international conference


• NSAID潰瘍予防の現状 整形外科医に対するアンケート調査解析

  津村 英隆, 田村 勇, 石田 司, 鎮西 亮, 田中 擴址, 塩見 英之, 増田 充弘, 森田 圭紀, 吉田 優, 久津見 弘, 井口 秀人, 東 健

  (一財)日本消化器病学会, Mar. 2007, 日本消化器病学会雑誌, 104(臨増総会) (臨増総会), A88 - A88, Japanese


• 病原性大腸菌感染症におけるIgG Fc受容体の役割

  増田 充弘, 吉田 優, 石田 司, 鎮西 亮, 田中 擴址, 高川 哲也, 塩見 英之, 森田 圭紀, 久津見 弘, 東 健

  (一財)日本消化器病学会, Mar. 2007, 日本消化器病学会雑誌, 104(臨増総会) (臨増総会), A150 - A150, Japanese


• Endoscopic submucosal dissection using water jet short needle knives (Flush knife) for the treatment of gastrointestinal epithelial neoplasms

  T. Toyonaga, H. Inokuchi, M. Man-I, Y. Morita, M. Yoshida, H. Kutsumi, T. Azuma

  2007, Acta Endoscopica, 37(5) (5), 645 - 655, French

  Book review


• Hemosuccus pancreaticus.

  Hiromu Kutsumi, Yoshinori Morita, Masaru Yoshida

  Dec. 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 4(12) (12), xx - XX, English, International magazine


• 【感染症と発癌】 肝吸虫と胆管癌

  久津見 弘, 森田 佳紀, 吉田 優, 東 健, 井口 秀人

  (株)北隆館, Nov. 2006, BIO Clinica, 21巻, 12号, pp. 1070-1073(12) (12), 1070 - 1073, Japanese


• ヘリコバクターピロリ菌除菌療法後の下部食道の組織学的変化への影響(原標題は英語)

  豊田昌徳, 白坂大輔, 三木生也, 松本優子, 奥野達哉, 三谷年史, 宮地英行, 堀順子, 吉田志栄, 茶屋原菜穂子, 田中敏雄, 花房正雄, 鳥尾直美, 森田圭紀, 田村孝雄, 青山伸郎, 東健

  10 Sep. 2006, 日本消化器病学会雑誌, 103, A764, Japanese


• 当院における大腸腫瘍(特にLST病変)に対する治療戦略

  森田 圭紀, 豊田 昌徳, 池原 伸直, 東 健

  (一社)日本消化器内視鏡学会, Sep. 2006, Gastroenterological Endoscopy, 48(Suppl.2) (Suppl.2), 2181 - 2181, Japanese


• 【内視鏡的粘膜下層剥離術(ESD)のトレーニングとリスクマネージメント】 ESD習得のためのトレーニング ライブデモンストレーションセミナーやハンズオンセミナーの有効活用

  MORITA YOSHINORI, KUTSUMI HIROMU, Aoyama Nobuo

  (株)日本メディカルセンター, Jul. 2006, 臨床消化器内科, 21(9) (9), 1269 - 1274, Japanese

  Introduction scientific journal


• Helicobacter pylori infection is associated with an increased risk of colonic adenomatous polyp

  Takashi Ando, Shigeto Mizuno, Yoshinori Morita, Toshio Inui, Akihiro Asakawa, Naohiko Ueno, Takeshi Ishikawa, Yasuyuki Nagao, Nobuyuki Seto, Akiko Komatsu, Tuguhiro Matsumoto, Haruki Kato, Toshikazu Yoshikawa

  Apr. 2006, GASTROENTEROLOGY, 130(4) (4), A317 - A317, English

  Summary international conference


• How Can We Overcome the Difficult Cases in Early Gastric Cancer Treatment with ESD Method?: Challenging New Technique with Double Scope ESD

  Yoshinori Morita, Ikuya Miki, Toshifumi Mitani, Masanori Toyoda, Toshio Tanaka, Naomi Torio, Daisuke Shirasaka, Masaru Yoshida, Takao Tamura, Hiromu Kutsumi, Nobuo Aoyama, Takeshi Azuma

  Apr. 2006, GASTROINTESTINAL ENDOSCOPY, 63(5) (5), AB251 - AB251, English

  Summary international conference


• 【こだわりのESD】 安全確実なESDを目指した高周波電源設定

  MORITA, Yoshinori, 吉村兼, 三谷年史, 豊田昌徳, 花房正雄, 三木生也, SHIRASAKA, Daisuke, AOYAMA, Nobuo, AZUMA, Takeshi

  (株)東京医学社, Feb. 2006, 消化器内視鏡, 18(2) (2), 157 - 162, Japanese

  Introduction scientific journal


• 【H.pylori除菌と消化性潰瘍・関連疾患 基礎・臨床研究のアップデート】 H.pylori除菌療法 一次除菌療法 海外における最近のfirst-line therapyに関する動向

  三木生也, SHIRASAKA, Daisuke, MORITA, Yoshinori, 青山伸朗

  (株)日本臨床社, Nov. 2005, 日本臨床, 63(増刊11 H.pylori除菌と消化性潰瘍・関連疾患) (増刊11 H.pylori除菌と消化性潰瘍・関連疾患), 418 - 420, Japanese

  Introduction scientific journal


• 【Helicobacter pylori感染と胃癌研究における最新の進歩】 Helicobacter pyloriによるCOX-2誘導は胃発癌にいかに関与するか

  SHIRASAKA, Daisuke, 三木生也, MORITA, Yoshinori, AOYAMA, Nobuo

  (株)先端医学社, Oct. 2005, Helicobacter Research, 9(5) (5), 379 - 384, Japanese

  Introduction scientific journal


• 消化器内視鏡教育を考える 当院におけるESD(内視鏡的粘膜下層剥離術)普及に向けての取り組み

  森田 圭紀, 青山 伸郎, 東 健

  (一社)日本消化器内視鏡学会, Sep. 2005, Gastroenterological Endoscopy, 47(Suppl.2) (Suppl.2), 1805 - 1805, Japanese


• ESDによる早期胃癌治療の適応と限界

  森田 圭紀, 青山 伸郎, 東 健

  (一社)日本消化器内視鏡学会, Sep. 2005, Gastroenterological Endoscopy, 47(Suppl.2) (Suppl.2), 1992 - 1992, Japanese


• 食道癌に対する化学放射線療法を含む集学的治療の新しい展開 食道癌放射線化学療法患者に対する遺伝子型診断を用いた治療効果予測の可能性について

  奥野 達哉, 田村 孝雄, 栄田 敏之, 山田 敏雄, 三木 生也, 茶屋原 菜穂子, 森田 圭紀, 白坂 大輔, 津田 政広, 青山 伸郎, 奥村 勝彦, 春日 雅人

  (一社)日本癌治療学会, Sep. 2005, 日本癌治療学会誌, 40(2) (2), 286 - 286, Japanese


• 進行・再発大腸癌に対するCPT-11+5-FU/LV+UFT/LV併用化学療法の第I相臨床試験

  茶屋原 菜穂子, 田村 孝雄, 奥野 達哉, 白坂 大輔, 森田 圭紀, 三木 生也, 日野 泰久, 津田 政広, 山田 浩幸, 青山 伸郎, 春日 雅人, 西崎 朗, 仁木 敏晴, 吉川 幸信

  (一社)日本癌治療学会, Sep. 2005, 日本癌治療学会誌, 40(2) (2), 318 - 318, Japanese


• 腹膜転移を伴う胃癌に対するDocetaxel(DOC)+S-1療法の経験

  茶屋原 菜穂子, 田村 孝雄, 奥野 達哉, 花房 正雄, 白坂 大輔, 森田 圭紀, 三木 生也, 日野 泰久, 津田 政広, 山田 浩幸, 青山 伸郎, 春日 雅人

  (一社)日本癌治療学会, Sep. 2005, 日本癌治療学会誌, 40(2) (2), 472 - 472, Japanese


• 消化器内視鏡教育を考える 当院におけるESD(内視鏡的粘膜下層剥離術)普及に向けての向り組み

  森田 圭紀, 青山 伸郎, 東 健

  (一社)日本消化器がん検診学会, Sep. 2005, 日本消化器集団検診学会雑誌, 43(5) (5), 135 - 135, Japanese


• 消化器内視鏡教育を考える 当院におけるESD(内視鏡的粘膜下層剥離術)普及に向けての取り組み

  森田 圭紀, 青山 伸郎, 東 健

  (一財)日本消化器病学会, Sep. 2005, 日本消化器病学会雑誌, 102(臨増大会) (臨増大会), A451 - A451, Japanese


• Docetaxel+S-1療法により著明な腹水減少を認めた胃癌の2例

  茶屋原 菜穂子, 田村 孝雄, 奥野 達哉, 白坂 大輔, 森田 圭紀, 三木 生也, 日野 泰久, 津田 政弘, 山田 浩幸, 青山 伸郎, 春日 雅人

  (一財)日本消化器病学会, Sep. 2005, 日本消化器病学会雑誌, 102(臨増大会) (臨増大会), A732 - A732, Japanese


• II cに肉眼形態及び病理組織像が類似したLST‐NG pseudo‐depressed typeの1例

  奥野達哉, 青山伸郎, 池原伸直, 森田圭紀, 吉田志栄, 宮地英行, 茶屋原菜穂子, 堀順子, 三谷年史, 豊田昌徳, 松本優子, 大須賀達也, 三木生也, 白坂大輔, 田村孝雄, 春日雅人, 蓮尾直輝, 佐竹信哉, 中山文仁, 横崎宏

  (株)日本メディカルセンター, Jul. 2005, 早期大腸癌, 9(4) (4), 388 - 388, Japanese


• Single and double mutations in gyrA but not in gyrB are associated with levofloxacin resistance in Helicobacter pylori

  H Miyachi, D Sirasaka, Miki, I, Y Matsumoto, Y Morita, T Tamura, N Aoyama, M Kasuga

  Apr. 2005, GASTROENTEROLOGY, 128(4) (4), A429 - A429, English

  Summary international conference


• EBMに基づいた早期大腸癌の治療選択 EMR,ESD,鏡視下手術 当院の大腸腫瘍に対する内視鏡治療の現状と展望

  池原 伸直, 森田 圭紀, 青山 伸郎

  (一社)日本消化器内視鏡学会, Apr. 2005, Gastroenterological Endoscopy, 47(Suppl.1) (Suppl.1), 633 - 633, Japanese


• 大腸sm癌におけるV型pit pattern分類の検討 箱根ピットパターンシンポジウム後の再検討

  吉田 志栄, 青山 伸郎, 池原 伸直, 茶屋原 菜穂子, 堀 順子, 宮地 英行, 奥野 達哉, 豊田 昌徳, 松本 優子, 三谷 年史, 大須賀 達也, 三木 生也, 中原 貴子, 森田 圭紀, 白坂 大輔, 田村 孝雄

  (一社)日本消化器内視鏡学会, Apr. 2005, Gastroenterological Endoscopy, 47(Suppl.1) (Suppl.1), 751 - 751, Japanese


• 当科で経験し得た下咽頭早期病変について Dyplasiaの評価を中心に

  奥野 達哉, 白坂 大輔, 青山 伸郎, 池原 伸直, 吉田 志栄, 宮地 英行, 茶屋原 菜穂子, 堀 順子, 三谷 年史, 豊田 昌徳, 松本 優子, 大須賀 達也, 三木 生也, 森田 圭紀, 田村 孝雄, 春日 雅人

  (一社)日本消化器内視鏡学会, Apr. 2005, Gastroenterological Endoscopy, 47(Suppl.1) (Suppl.1), 757 - 757, Japanese


• 早期胃癌に対する内視鏡的粘膜下層剥離術(ESD)の標準化に向けての新たな工夫 新世代の高周波発生装置VIO 300Dを用いて

  森田 圭紀, 三谷 年史, 青山 伸郎

  (一社)日本消化器内視鏡学会, Apr. 2005, Gastroenterological Endoscopy, 47(Suppl.1) (Suppl.1), 766 - 766, Japanese


• H.pylori除菌後の逆流性食道炎発症に関する検討

  豊田 昌徳, 青山 伸郎, 白坂 大輔, 田村 孝雄, 三木 生也, 森田 圭紀, 大須賀 達也, 池原 伸直, 奥野 達哉, 松本 優子, 三谷 年史, 宮地 英行, 吉田 志栄, 堀 順子, 茶屋原 菜穂子, 渡部 義則, 春日 雅人

  (一財)日本消化器病学会, Mar. 2005, 日本消化器病学会雑誌, 102(臨増総会) (臨増総会), A284 - A284, Japanese


• 【Helicobacter pylori非侵襲的診断法の実際 診療現場の最前線より】 Helicobacter pylori感染診断法としての血清ペプシノゲン測定の意義

  SHIRASAKA, Daisuke, 三木生也, MORITA, Yoshinori, AOYAMA, Nobuo

  (株)先端医学社, Feb. 2005, Helicobacter Research, 9(1) (1), 43 - 48, Japanese

  Introduction scientific journal


• 【Helicobacter pylori疫学のその後 将来的予測からみた疾病動向】 H.pylori感染率の減少により疾病構造は変化するのか? 大腸憩室,大腸癌

  SHIRASAKA, Daisuke, 三木生也, MORITA, Yoshinori, AOYAMA, Nobuo

  (株)先端医学社, Dec. 2004, Helicobacter Research, 8(6) (6), 517 - 522, Japanese

  Introduction scientific journal


• 当院における早期胃癌に対する切開・剥離法(ESD)の現状と問題点

  森田 圭紀, 三谷 年史, 青山 伸郎

  (一社)日本消化器内視鏡学会, Sep. 2004, Gastroenterological Endoscopy, 46(Suppl.2) (Suppl.2), 1933 - 1933, Japanese


• 早期胃癌における切開・剥離法の工夫〜新世代の高周波発生装置(VIO:ERBE)の使用経験

  森田 圭紀, 青山 伸郎, 吉村 兼, 福田 昌輝, 三谷 年史, 白坂 大輔, 三木 生也, 豊田 昌徳, 春日 雅人

  (一社)日本消化器内視鏡学会, Sep. 2004, Gastroenterological Endoscopy, 46(Suppl.2) (Suppl.2), 1937 - 1937, Japanese


• GERDの典型および非典型症状に対する治療の検討

  白坂 大輔, 青山 伸郎, 前川 修司, 森田 圭紀, 三木 生也, 大須賀 達也, 松本 優子, 奥野 達哉, 豊田 昌徳, 三谷 年史, 田村 孝雄, 春日 雅人

  (一財)日本消化器病学会, Sep. 2004, 日本消化器病学会雑誌, 101(臨増大会) (臨増大会), A677 - A677, Japanese


• 食道扁平上皮癌に対する放射線化学療法後のnon CR症例とCR後の再発症例に対する治療戦略

  三木 生也, 田村 孝雄, 奥野 達哉, 白坂 大輔, 宮崎 博之, 津田 政弘, 山田 浩幸, 森田 圭紀, 青山 伸郎, 春日 雅人

  (一財)日本消化器病学会, Sep. 2004, 日本消化器病学会雑誌, 101(臨増大会) (臨増大会), A679 - A679, Japanese


• 当院における早期胃癌に対するEMR 切開・剥離法を導入して

  森田 圭紀, 三谷 年史, 青山 伸郎

  (一社)日本消化器内視鏡学会, Apr. 2004, Gastroenterological Endoscopy, 46(Suppl.1) (Suppl.1), 644 - 644, Japanese


• EHL(endoscopic hemorrhoidal ligation)デバイスによる直腸カルチノイドの治療

  大須賀 達也, 森田 圭紀, 青山 伸郎

  (一社)日本消化器内視鏡学会, Apr. 2004, Gastroenterological Endoscopy, 46(Suppl.1) (Suppl.1), 736 - 736, Japanese


• 【Barrett食道・腺癌治療へのアプローチ】 Barrett食道及び逆流性食道炎の病態生理・診断 Helicobacter pylori除菌が下部食道に与える影響について

  渡部義則, AOYAMA, Nobuo, TAMURA, Takao, SHIRASAKA, Daisuke, MAEKAWA,Shuji, MORITA, Yoshinori, 中原貴子, 西岡千晴, 三木生也, 加地正明, 福田昌輝, 大須賀達也, KASUGA, Masato

  (株)アークメディア, Oct. 2003, 消化器医学, 1, 46 - 52, Japanese

  Introduction scientific journal


• 早期胃癌に対するITナイフ法における工夫について

  森田 圭紀, 福田 昌輝, 青山 伸郎

  (一社)日本消化器内視鏡学会, Sep. 2003, Gastroenterological Endoscopy, 45(Suppl.2) (Suppl.2), 1526 - 1526, Japanese


• 内視鏡的食道静脈瘤硬化療法及び結紮術同時併用療法(EISL)における改良型連発式EVLデバイスの使用経験

  前川 修司, 青山 伸郎, 加地 正明, 白坂 大輔, 中原 貴子, 西岡 千晴, 森田 圭紀, 福田 昌輝, 三木 生也, 大須賀 達也

  (一社)日本消化器内視鏡学会, Sep. 2003, Gastroenterological Endoscopy, 45(Suppl.2) (Suppl.2), 1731 - 1731, Japanese


• ヒスタミン受容体拮抗薬がH.pylori陽性者の胃における好中球活性化に対する影響について

  福田 昌輝, 青山 伸郎, 白坂 大輔, 田村 孝雄, 森田 圭紀, 中原 貴子, 西岡 千晴, 渡部 義則, 加地 正明, 三木 生也, 大須賀 達也, 春日 雅人

  (一財)日本消化器病学会, Sep. 2003, 日本消化器病学会雑誌, 100(臨増大会) (臨増大会), A610 - A610, Japanese


• Levofloxacinを用いたHelicobacter pyloriの二次除菌に関する検討

  渡部 義則, 青山 伸郎, 田村 孝雄, 白坂 大輔, 前川 修司, 森田 圭紀, 中原 貴子, 西岡 千晴, 三木 生也, 加地 正明, 福田 昌輝, 大須賀 達也, 春日 雅人

  (一財)日本消化器病学会, Sep. 2003, 日本消化器病学会雑誌, 100(臨増大会) (臨増大会), A618 - A618, Japanese


• 早期胃癌に対するITナイフ法における工夫について

  森田 圭紀, 白坂 大輔, 青山 伸郎

  (一社)日本消化器内視鏡学会, Apr. 2003, Gastroenterological Endoscopy, 45(Suppl.1) (Suppl.1), 599 - 599, Japanese


• 大腸腫瘍におけるMetallothionein蛋白発現の免疫組織学的検討

  黒田 浩平, 青山 伸郎, 田村 孝雄, 白坂 大輔, 前川 修司, 中原 貴子, 西岡 千晴, 森田 圭紀, 春日 雅人, 窪田 伸三, 伊藤 利江子

  (一社)日本消化器内視鏡学会, Apr. 2003, Gastroenterological Endoscopy, 45(Suppl.1) (Suppl.1), 653 - 653, Japanese


• ステロイド未使用の活動期潰瘍性大腸炎に対する白血球除去療法による緩解導入

  西岡 千晴, 青山 伸郎, 白坂 大輔, 前川 修司, 森田 圭紀, 中原 貴子, 三木 生也, 加地 正明, 渡部 義則, 大須賀 達也, 福田 昌輝, 中西 昌平, 深川 雅史, 谷 聡, 春日 雅人

  (一財)日本消化器病学会, Mar. 2003, 日本消化器病学会雑誌, 100(臨増総会) (臨増総会), A254 - A254, Japanese


• 胃排出能の変化からみたNUDのH.pylori除菌

  白坂 大輔, 青山 伸郎, 田村 孝雄, 前川 修司, Casmir Wambura, 森田 圭紀, 中原 貴子, 西岡 千晴, 加地 正明, 三木 生也, 渡部 義則, 大須賀 達也, 福田 昌輝

  (一財)日本消化器病学会, Mar. 2003, 日本消化器病学会雑誌, 100(臨増総会) (臨増総会), A280 - A280, Japanese


• MDR1遺伝子型とジゴキシン十二指腸内投与後の吸収速度との相関

  和田 敦, 中村 任, 堀之内 正則, 森田 圭紀, 田村 孝雄, 青山 伸郎, 栄田 敏之, 春日 雅人, 奥村 勝彦

  (一社)日本臨床薬理学会, Jan. 2003, 臨床薬理, 34(1) (1), 39S - 40S, Japanese


• Helicobacter pylori除菌後の逆流性食道炎に関する検討

  渡部 義則, 青山 伸郎, 田村 孝雄, 白坂 大輔, Casmir Wambura, 前川 修司, 森田 圭紀, 中原 貴子, 西岡 千晴, 三木 生也, 加地 正明, 福田 昌輝, 大須賀 達也

  (一社)日本消化器内視鏡学会, Sep. 2002, Gastroenterological Endoscopy, 44(Suppl.2) (Suppl.2), 1486 - 1486, Japanese


• ITナイフ法におけるプレカット時の工夫と安全性について

  森田 圭紀, 青山 伸郎, 白坂 大輔, 前川 修司, 黒田 浩平, 江原 重幸, 西岡 千晴, 中原 貴子, 三木 生也, 加地 正明, 渡部 義則, 大須賀 達也, 福田 昌輝, 吉村 兼, 田村 孝雄, 春日 雅人

  (一社)日本消化器内視鏡学会, Sep. 2002, Gastroenterological Endoscopy, 44(Suppl.2) (Suppl.2), 1497 - 1497, Japanese


• 大腸癌におけるIIcの頻度

  西岡 千晴, 青山 伸郎, 田村 孝雄, 坂下 正典, 白坂 大輔, 前川 修司, 中原 貴子, 森田 圭紀, 大須賀 達也, 春日 雅人

  (一社)日本消化器内視鏡学会, Sep. 2002, Gastroenterological Endoscopy, 44(Suppl.2) (Suppl.2), 1631 - 1631, Japanese


• MDR-1高発現細胞株を用いたCD-DST法(C法)とWST-1 assay(W法)の比較検討

  中原 貴子, 田村 孝雄, 青山 伸郎, 栄田 敏之, 中村 任, 白坂 大輔, 西岡 千晴, 森田 圭紀, 渡部 義則, 神垣 隆, 春日 雅人

  (一社)日本癌治療学会, Sep. 2002, 日本癌治療学会誌, 37(2) (2), 369 - 369, Japanese


• 当院における食道扁平上皮癌に対するchemoradiationの成績

  三木 生也, 田村 孝雄, 青山 伸郎, 中原 貴子, 西岡 千晴, 森田 圭紀, 加地 正明, 白坂 大輔, 前川 修司, 春日 雅人

  (一社)日本癌治療学会, Sep. 2002, 日本癌治療学会誌, 37(2) (2), 390 - 390, Japanese


• cDNA microarrayを用いたCDDPに対するMDR1過剰発現細胞の遺伝子発現変化解析

  西岡 千晴, 中村 任, 栄田 敏之, 奥村 勝彦, 中原 貴子, 森田 圭紀, 大須賀 達也, 白坂 大輔, 田村 孝雄, 青山 伸郎, 春日 雅人

  (一社)日本癌治療学会, Sep. 2002, 日本癌治療学会誌, 37(2) (2), 508 - 508, Japanese


• MDR1遺伝子型に依存したジゴキシン単回経口投与後の血清中濃度推移

  堀之内 正則, 栄田 敏之, 中村 任, 角本 幹夫, 大本 暢子, 阪井 俊介, 森田 圭紀, 田村 孝雄, 青山 伸郎, 平井 みどり, 春日 雅人, 奥村 勝彦

  (一社)日本TDM学会, Jul. 2002, TDM研究, 19(3) (3), 242 - 247, Japanese


• 興味ある肉眼形態(IIa+IIc?)を呈した早期大腸癌の1例

  西岡 千晴, 青山 伸郎, 田村 孝雄, 白坂 大輔, 黒田 浩平, 前川 修司, 井上 崇, 江原 重幸, 中原 貴子, 森田 圭紀, 大須賀 達也, 春日 雅人, 市原 隆夫, 黒田 嘉和, 南 利江子

  (株)日本メディカルセンター, Jul. 2002, 早期大腸癌, 6(4) (4), 374 - 375, Japanese


• LST(non-granular type)と陥凹型の形態的特徴を有した低分化腺癌の1例

  中原 貴子, 青山 伸郎, 田村 孝雄, 白坂 大輔, 黒田 浩平, 前川 修司, 江原 重幸, 井上 崇, 森田 圭紀, 西岡 千晴, 大須賀 達也, 春日 雅人, 南 利江子, 池原 英夫

  (株)日本メディカルセンター, Jul. 2002, 早期大腸癌, 6(4) (4), 376 - 376, Japanese


• MDR1遺伝子型とジゴキシン血清中濃度推移との相関

  堀之内 正則, 中村 任, 角本 幹夫, 大本 暢子, 喜多 知子, 栄田 敏之, 阪井 俊介, 森田 圭紀, 田村 孝雄, 平井 みどり, 青山 伸郎, 春日 雅人, 奥村 勝彦

  (一社)日本TDM学会, Apr. 2002, TDM研究, 19(2) (2), 117 - 118, Japanese


• 大腸内視鏡治療におけるアルゴンプラズマ凝固法(APC)の有用性について

  森田 圭紀, 青山 伸郎, 前川 修司, 白坂 大輔, 黒田 浩平, 井上 崇, 江原 重幸, 西岡 千晴, 中原 貴子, 三木 生也

  (一社)日本消化器内視鏡学会, Mar. 2002, Gastroenterological Endoscopy, 44(Suppl.1) (Suppl.1), 537 - 537, Japanese


• クローン病の腸管狭窄に対する内視鏡的バルーン拡張術 4症例の経験

  井上 崇, 青山 伸郎, 西岡 千晴, 白坂 大輔, 前川 修司, 江原 重幸, 中原 貴子, 森田 圭紀, 三木 生也, 加地 正明

  (一社)日本消化器内視鏡学会, Mar. 2002, Gastroenterological Endoscopy, 44(Suppl.1) (Suppl.1), 541 - 541, Japanese


• 内視鏡画像ファイリングシステムの有用性 ネット時代の内視鏡画像・ビデオクリップ公開サービス

  吉村 兼, 白坂 大輔, 黒田 浩平, 前川 修司, 井上 崇, 森田 圭紀, 田村 孝雄, 青山 伸郎, 前田 英一

  (一社)日本消化器内視鏡学会, Mar. 2002, Gastroenterological Endoscopy, 44(Suppl.1) (Suppl.1), 582 - 582, Japanese


• MDR1遺伝子多型に依存したジゴキシン体内動態

  堀之内 正則, 中村 任, 栄田 敏之, 阪井 俊介, 森田 圭紀, 田村 孝雄, 青山 伸郎, 白川 利朗, 松尾 雅文, 春日 雅人

  (一社)日本臨床薬理学会, Mar. 2002, 臨床薬理, 33(2) (2), 255S - 256S, Japanese


• 高容量の抗生物質による除菌成否の検討

  白坂 大輔, 青山 伸郎, 黒田 浩平, 前川 修司, 井上 崇, 江原 重幸, 渡部 義則, 中原 貴子, 西岡 千晴, 森田 圭紀, 加地 正明, 三木 生也, Casmir Wambura, 大須賀 達也, 福田 昌輝, 田村 孝雄, 宮本 正喜, 春日 雅人

  (一財)日本消化器病学会, Mar. 2002, 日本消化器病学会雑誌, 99(臨増総会) (臨増総会), A208 - A208, Japanese


• MDR1 2677位遺伝子型とジゴキシン体内動態との相関

  堀之内 正則, 栄田 敏之, 中村 任, 森田 圭紀, 田村 孝雄, 青山 伸郎, 春日 雅人, 奥村 勝彦

  (公社)日本薬学会, Mar. 2002, 日本薬学会年会要旨集, 122年会(4) (4), 127 - 127, Japanese


• 【痔核の新しい治療法】EHLデバイスによる内視鏡的内痔核治療の検討

  大須賀 達也, 工藤 進英, 梅里 和哉, 森田 圭紀, 為我井 芳郎, 山野 泰穂, 今井 靖

  (一社)日本大腸肛門病学会, Oct. 2001, 日本大腸肛門病学会雑誌, 54(10) (10), 905 - 909, Japanese


• O-8 MDR1 遺伝子型に依存したジゴキシン単回経口投与後の体内動態

  堀之内 正則, 栄田 敏之, 中村 任, 角本 幹夫, 大本 暢子, 阪井 俊介, 森田 圭紀, 田村 孝雄, 青山 伸郎, 春日 雅人, 平井 みどり, 奥村 勝彦

  日本医療薬学会, 01 Sep. 2001, 日本医療薬学会年会講演要旨集, 11, 80 - 80, Japanese


• 出血性胃十二指腸潰瘍に対する内視鏡的止血術におけるアルゴンプラズマ凝固法の位置付け

  前川 修司, 青山 伸郎, 井上 崇, 白坂 大輔, 江原 重幸, 黒田 浩平, 中原 貴子, 西岡 千晴, 森田 圭紀, 三木 生也

  (一社)日本消化器内視鏡学会, Sep. 2001, Gastroenterological Endoscopy, 43(Suppl.2) (Suppl.2), 1656 - 1656, Japanese


• MDR1遺伝子型に依存したMDR1の基質の体内動態

  堀之内 正則, 栄田 敏之, 中村 任, 角本 幹夫, 喜多 知子, 阪井 俊介, 森田 圭紀, 田村 孝雄, 青山 伸郎, 平井 みどり

  日本癌学会, Sep. 2001, 日本癌学会総会記事, 60回, 217 - 217, Japanese


• LST様形態を示したserrated adenoma由来と思われるmp癌の1例

  前川 修司, 井上 崇, 森田 圭紀, 中原 貴子, 西岡 千晴, 黒田 浩平, 青山 伸郎, 坂下 正典

  (株)日本メディカルセンター, Jul. 2001, 早期大腸癌, 5(4) (4), 400 - 400, Japanese


• ヒト大腸がん及び大腸ポリープにおける薬物輸送担保のリアルタイムPCR解析

  角本 幹夫, 中村 任, 大本 暢子, 栄田 敏之, 森田 圭紀, 田村 孝雄, 青山 伸郎, 春日 雅人, 白川 利朗, 松尾 雅文

  (公社)日本薬学会, Mar. 2001, 日本薬学会年会要旨集, 121年会(3) (3), 28 - 28, Japanese


• Caco-2細胞及びヒト十二指腸上皮細胞における薬物輸送担体・代謝酵素発現量のリアルタイムPCR解析

  大本 暢子, 角本 幹夫, 中村 任, 栄田 敏之, 森田 圭紀, 田村 孝雄, 青山 伸郎, 白川 利朗, 松尾 雅文, 春日 雅人

  (公社)日本薬学会, Mar. 2001, 日本薬学会年会要旨集, 121年会(3) (3), 113 - 113, Japanese


• MDR1遺伝子型とジゴキシン体内動態との相関

  堀之内 正則, 角本 幹夫, 大本 暢子, 中村 任, 喜多 知子, 栄田 敏之, 阪井 俊介, 森田 圭紀, 田村 孝雄, 平井 みどり

  (公社)日本薬学会, Mar. 2001, 日本薬学会年会要旨集, 121年会(3) (3), 168 - 168, Japanese


• pit pattern診断が深達度診断に有用であった側方発育型腫瘍(非顆粒型)の1例

  石川 恵子, 工藤 進英, 為我井 芳郎, 山野 泰穂, 今井 靖, 田村 知之, 木暮 悦子, 孟 尼麗, 松田 知己, 関口 恭弘, 成澤 亜古, 富松 英人, 中原 貴子, 西岡 千晴, 森田 圭紀

  (株)医学書院, Feb. 2001, 胃と腸, 36(2) (2), 122 - 124, Japanese


• EHLデバイスによる内視鏡的内痔核治療の検討

  森田 圭紀, 工藤 進英, 為我井 芳郎, 山野 泰穂, 今井 靖, 日下 尚志, 作左部 大, 木暮 悦子, 松田 知己, 富松 英人

  (一社)日本消化器内視鏡学会, Sep. 2000, Gastroenterological Endoscopy, 42(Suppl.2) (Suppl.2), 1700 - 1700, Japanese


• 痔核治療の新しい工夫 EHLデバイスによる内視鏡的内痔核治療の検討

  森田 圭紀, 工藤 進英, 為我井 芳郎, 山野 泰穂, 今井 靖

  (一社)日本大腸肛門病学会, Sep. 2000, 日本大腸肛門病学会雑誌, 53(9) (9), 640 - 640, Japanese


• V型pit patternの病理組織学的検討 scratch signと逆噴射の所見

  松田 知己, 工藤 進英, 為我井 芳郎, 山野 泰穂, 今井 靖, 日下 尚志, 作左部 大, 木暮 悦子, 森田 圭紀, 西岡 千晴

  (一社)日本消化器内視鏡学会, Sep. 2000, Gastroenterological Endoscopy, 42(Suppl.2) (Suppl.2), 1628 - 1628, Japanese


• 小さなIIIL型pit patternの検討

  中原 貴子, 工藤 進英, 為我井 芳郎, 山野 泰穂, 今井 靖, 木暮 悦子, 松田 知己, 森田 圭紀, 西岡 千晴, 原 栄志

  (一社)日本消化器内視鏡学会, Sep. 2000, Gastroenterological Endoscopy, 42(Suppl.2) (Suppl.2), 1711 - 1711, Japanese


• 大腸腫瘍の内視鏡診断と治療におけるピットパターン診断の有用性について

  木暮 悦子, 工藤 進英, 為我井 芳郎, 山野 泰穂, 今井 靖, 松田 知己, 森田 圭紀, 西岡 千晴, 中原 貴子, 原 栄志

  (一社)日本消化器内視鏡学会, Sep. 2000, Gastroenterological Endoscopy, 42(Suppl.2) (Suppl.2), 1711 - 1711, Japanese


• 陥凹を有する非顆粒型側方発育型腫瘍の1例

  前川 修司, 井上 崇, 森田 圭紀, 中原 貴子, 西岡 千晴, 黒田 浩平, 青山 伸郎, 坂下 正典

  (一社)日本消化器内視鏡学会, Sep. 2000, Gastroenterological Endoscopy, 42(Suppl.2) (Suppl.2), 1772 - 1772, Japanese


• 【多発大腸癌】大腸の異時性多発癌におけるIIc型大腸病変

  今井 靖, 工藤 進英, 為我井 芳郎, 山野 泰穂, 成澤 亜古, 木暮 悦子, 松田 知己, 中原 貴子, 西岡 千晴, 森田 圭紀, 原 栄志, 前田 聡, 小幡 まこと, 工藤 由比, 沢 秀彦, 梅里 和哉, 工藤 智洋, 池原 伸直, 高見 啓央, 大須賀 達也, 日下 尚志, 作左部 大

  (株)医学書院, Jul. 2000, 胃と腸, 35(8) (8), 1031 - 1034, Japanese


• 【大腸癌診療の実際 臨床研究から実地診療へ】表面型腫瘍の診断 拡大内視鏡の意義

  工藤 進英, 今井 靖, 松田 知己, 中原 貴子, 為我井 芳郎, 山野 泰穂, 木暮 悦子, 西岡 千晴, 森田 圭紀, 原 栄志, 前田 聡, 小幡 まこと, 工藤 由比, 沢 秀彦, 梅里 和哉, 日下 尚志, 作左部 大

  (株)東京医学社, Jun. 2000, 臨床成人病, 30(6) (6), 755 - 758, Japanese


• 新型EHLデバイスによる内視鏡的内痔核治療の検討

  森田 圭紀, 工藤 進英, 為我井 芳郎, 山野 泰穂, 今井 靖, 木暮 悦子, 松田 知己, 孟 尼麗, 成澤 亜古, 富松 英人

  (一社)日本消化器内視鏡学会, Apr. 2000, Gastroenterological Endoscopy, 42(Suppl.1) (Suppl.1), 642 - 642, Japanese


• 【Evidenceに基づく内科的治療の進め方】消化器疾患 大腸ポリペクトミーとがん発生阻止

  工藤 進英, 今井 靖, 為我井 芳郎, 山野 泰穂, 日下 尚志, 作左部 大, 木暮 悦子, 松田 知己, 成澤 亜古, 富松 英人, 中原 貴子, 西岡 千晴, 森田 圭紀, 原 栄志

  (株)最新医学社, Mar. 2000, 最新医学, 55(増刊) (増刊), 683 - 697, Japanese


• 【消化管ポリポーシス2000】大腸ポリポーシスの拡大内視鏡検査 大腸腺腫症,aberrant crypt fociを含めて

  工藤 進英, 西岡 千晴, 為我井 芳郎, 山野 泰穂, 今井 靖, 木暮 悦子, 松田 知己, 成澤 亜古, 富松 英人, 森田 圭紀, 中原 貴子, 原 栄志, 日下 尚志, 作左部 大

  (株)医学書院, Feb. 2000, 胃と腸, 35(3) (3), 393 - 399, Japanese


• 【大腸腫瘍の内視鏡診断は病理診断にどこまで近づくか】大腸拡大内視鏡診断はどこまで病理診断に近づいたか pit pattern診断と病理組織診断

  今井 靖, 工藤 進英, 松田 知己, 中原 貴子, 為我井 芳郎, 山野 泰穂, 日下 尚志, 粕谷 孝光, 木暮 悦子, 孟 尼麗, 成澤 亜古, 富松 英人, 西岡 千晴, 森田 圭紀, 原 栄志

  (株)医学書院, Dec. 1999, 胃と腸, 34(13) (13), 1645 - 1652, Japanese


• 【大腸腫瘍の内視鏡診断は病理診断にどこまで近づくか】拡大内視鏡診断が有用であったLST顆粒型早期大腸癌の1例

  中原 貴子, 工藤 進英, 山野 泰穂, 為我井 芳郎, 今井 靖, 木暮 悦子, 孟 尼麗, 松田 知己, 成澤 亜古, 西岡 千晴, 森田 圭紀, 富松 英人, 工藤 由比, 原 栄志

  (株)医学書院, Dec. 1999, 胃と腸, 34(13) (13), 1680 - 1681, Japanese


• 【小さな(大きさ2cm以下)進行癌】大きさ2cm以下大腸進行癌の発育進展 肉眼形態,割面組織像からみて

  為我井 芳郎, 工藤 進英, 日下 尚史, 山野 泰穂, 今井 靖, 粕谷 孝光, 木暮 悦子, 孟 尼麗, 松田 知己, 成澤 亜古, 富松 英人, 中原 貴子, 西岡 千晴, 森田 圭紀, 原 英志

  (株)日本メディカルセンター, Nov. 1999, 早期大腸癌, 3(6) (6), 541 - 549, Japanese


• 糖尿病治療中に蜂窩織炎を併発し診断された転移性臍腫瘍の1例

  馬田 さやか, 加地 正明, 森田 圭紀, 塚本 和也, 菅野 雅彦, 長谷川 博司, 大城 清, 藤井 正俊, 村上 啓治, 林 悟

  (一社)日本糖尿病学会, Sep. 1999, 糖尿病, 42(9) (9), 793 - 793, Japanese


• 【IIc由来のsm癌を考える】臨床の立場から 私はこう考える(1) 肉眼形態,pit patternからみたIIcの発育進展

  今井 靖, 工藤 進英, 為我井 芳郎, 山野 泰穂, 日下 尚志, 粕谷 孝光, 石川 恵子, 木暮 悦子, 田村 知之, 孟 尼麗, 金 柄老, 檜垣 智彦, 松田 知己, 関口 恭弘, 成澤 亜古, 富松 英人, 中原 貴子, 西岡 千晴, 森田 圭紀

  (株)日本メディカルセンター, Jul. 1999, 早期大腸癌, 3(4) (4), 319 - 324, Japanese


• アルコール依存症者及び一般検査におけるアルコール多飲者における内視鏡所見の検討 非飲酒者との比較

  菅野 雅彦, 藤井 正俊, 大城 清, 長谷川 博司, 犬島 浩一, 塚本 和也, 森田 圭紀, 加地 正明, 馬田 さやか, 村上 啓治

  (一社)日本消化器内視鏡学会, Apr. 1999, Gastroenterological Endoscopy, 41(Suppl.1) (Suppl.1), 817 - 817, Japanese

• 近畿live endoscopy 2017-2018 : Kinki live endoscopy on DVD

  小山, 恒男, 近畿内視鏡治療研究会, 豊永, 高史, 町田, 浩久, 滝本, 見吾, 上堂, 文也, 角嶋, 直美, 滝原, 浩守, 前田, 有紀, 梅垣, 英次, 道田, 知樹, 平澤, 大, 森田, 圭紀, 竹内, 洋司, 山本, 克己, 林, 武雅, 赤松, 拓司

  金原出版, 2020, Japanese, ISBN: 9784307204125


• 消化器内視鏡治療における高周波発生装置の使い方と注意点 改訂第3版 治療手技のコツと設定例 3. Endoscopic Submucosal Dissection (ESD), Swan Blade

  森田 圭紀

  Contributor, 日本メディカルセンター, 2020


• 近畿Live Endoscopy 2015-2016 / 近畿Live Endoscopy 2015-2016

  Morita Yoshinori

  金原出版, 2018, Japanese

  General book


• 教科書では教えてくれない!私の消化器内視鏡Tips / ESDはﾍﾟﾀﾞﾙﾜｰｸが重要

  Morita Yoshinori

  Others, 医学書院, 2018, English

  General book


• 食道・胃ESD / 実践編 Case study:部位別・難易度別攻略法 13.体上部大彎

  Morita Yoshinori

  Others, 羊土社, Mar. 2015, Japanese

  Scholarly book


• 食道・胃ESD / ESDの実際と基本手技：高周波発生装置と条件設定

  Morita Yoshinori

  Others, 羊土社, Mar. 2015, Japanese

  Scholarly book


• ESDライブセミナー KINKI ESD Live Seminar on DVD

  Morita Yoshinori

  Others, 金原出版株式会社, Sep. 2014, Japanese

  Scholarly book


• チーム医療のためのESDマニュアル / トレーニングシステム-ESDの安全確実な普及を目指して-

  Morita Yoshinori

  Others, 金原出版株式会社, Oct. 2013, Japanese

  Scholarly book


• 消化器内視鏡治療における高周波発生装置の使い方と注意点 / 治療手技のコツと設定例 Endoscopic Submucosal Dissection (14)SwanBlade

  Morita Yoshinori

  Others, 日本メディカルセンター, May 2013, Japanese

  Scholarly book


• Atras of endoscopic detection, characterization and treatment of early stage esophageal, gastric and intestinal cancer. / Atras of endoscopic detection, characterization and treatment of early stage esophageal, gastric and intestinal cancer.

  M.A. Tanimoto, R. Fujita, Morita Yoshinori

  Joint work, Editorial Alfil, May 2013, English

  Scholarly book


• 消化器内視鏡レクチャー / 【ひとりでも迷わない 上部消化管 治療内視鏡の極意-さあ、自信をもって始めてみましょう!-】 食道・胃ESDにおけるデバイスの使い分け

  Morita Yoshinori

  Others, 総合医学社, Apr. 2013, Japanese

  Scholarly book


• 大腸ESD / 達人のコツ：各種デバイスの特徴と手技の実際 Swan Blade

  Morita Yoshinori

  Others, 南江堂, Feb. 2013, Japanese

  Scholarly book


• 大腸ESD / 第IV章 大腸ESDの困難例と対処法 5.大型Is病変

  Morita Yoshinori, Toyonaga Takashi

  Others, 南江堂, Feb. 2013, Japanese

  Scholarly book


• 大腸ESD / 第III章 大腸ESDの実際 2.基本手技と治療戦略の立て方

  Morita Yoshinori, Toyonaga Takashi

  Others, 南江堂, Feb. 2013, Japanese

  Scholarly book


• 看護のための最新医学講座（第２版）第４巻 消化器疾患 / 【胃十二指腸疾患／過形成性ポリープ・腺腫・癌】

  AOYAMA, Nobuo, 伊藤(南) 利江子, SHIRASAKA, Daisuke, MORITA, Yoshinori

  Joint work, 中山書店, Mar. 2005, Japanese

  Scholarly book