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TACHIHARA Motoko
University Hospital / Respiratory Medicine
Associate Professor

Research activity information

■ Award
  • 2016 西日本がん研究機構（WJOG）, 平成27年度有吉・福岡賞, 個人・臨床研究
    Tachihara Motoko
    Publisher

■ Paper
  • Naoko Chayahara, Toru Mukohara, Motoko Tachihara, Yoshimi Fujishima, Atsushi Fukunaga, Ken Washio, Masatsugu Yamamoto, Kyosuke Nakata, Kazuyuki Kobayashi, Kei Takenaka, Masanori Toyoda, Naomi Kiyota, Kazutoshi Tobimatsu, Hisayo Doi, Naomi Mizuta, Naho Marugami, Atsushi Kawaguchi, Chikako Nishigori, Yoshihiro Nishimura, Hironobu Minami
    LESSONS LEARNED: The results of the APPEARANCE trial indicate that adapalene does not prevent acne-like rash over placebo when added to topical moisturizer and oral minocycline but instead may have a detrimental effect. Therefore, adapalene is not recommended as prophylaxis against acne-like rash induced by anti-epidermal growth factor receptor therapies.Given that acne-like rash was completely controlled with placebo in approximately half of patients, predictive measures to identify patients needing intensive prophylaxis are required. BACKGROUND: Anti-epidermal growth factor receptor (EGFR) therapies are frequently associated with acne-like rash. To evaluate the prophylactic efficacy of adapalene, a topical retinoid used as first-line therapy for acne vulgaris, we conducted a randomized, placebo-controlled, evaluator-blinded, left-right comparative trial. METHODS: Patients with non-small cell lung, colorectal, or head and neck cancer scheduled to receive anti-EGFR therapies were randomly assigned to once-daily adapalene application on one side of the face, with placebo on the other side. All patients had topical moisturizer coapplied to both sides of the face, and received oral minocycline. The primary endpoint was the difference in total facial lesion count of acne-like rash at 4 weeks. Secondary endpoints included complete control rate (CCR) of acne-like rash (≤5 facial lesions) and global skin assessment (Investigator's Global Assessment [IGA] scale, grade 0-4) at 4 weeks. Two blinded dermatologists independently evaluated the endpoints from photographs. RESULTS: A total of 36 patients were enrolled, of whom 26 were evaluable. Adapalene treatment was associated with a greater lesion count than placebo at 4 weeks, although the difference was not statistically significant (mean, 12.6 vs. 9.8, p = .12). All four patients with a difference >10 in lesion count between face sides had a greater count on the adapalene-treated side. No significant differences were observed in CCR of acne-like rash (54% vs. 50%) or IGA scale (mean grade, 1.9 vs. 1.7) between the adapalene and placebo sides. CONCLUSION: Adapalene is not recommended as prophylaxis against acne-like rash induced by anti-EGFR therapies.
    Jul. 2019, The oncologist, 24(7) (7), 885-e413, English, International magazine
    [Refereed]
    Scientific journal

  • Kiyoko Koyama, Naoko Katsurada, Naoe Jimbo, Motoko Tachihara, Daisuke Tamura, Kyosuke Nakata, Tatsuya Nagano, Masatsugu Yamamoto, Hiroshi Kamiryo, Kazuyuki Kobayashi, Tomoo Itoh, Yoshihiro Nishimura
    Transformation to small cell lung cancer is one phenomenon of acquired resistance to anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors in ALK rearrangement-positive non-small cell lung cancer (NSCLC). Few case reports have focused on other types of histological transformation. We report a case of transformation of ALK rearrangement-positive adenocarcinoma to NSCLC with neuroendocrine differentiation during alectinib therapy. A 36-year-old woman presented with a tumor in the left lower lobe and bone metastases. She was diagnosed with ALK rearrangement-positive adenocarcinoma by histopathology of the primary tumor. Alectinib had been effective for 8 months before new lesions appeared. Histopathological re-examination of a recurrent tumor revealed poorly differentiated carcinoma with insulinoma-associated protein 1 (INSM1) expression, which remained ALK-positive. Expression of CD133, BCL-2, and SOX2 was positive in comparison to the initial tumor. Expression of SOX2 became more strongly positive than it was before treatment. The immunohistochemical findings of these markers associated with cancer stem-like cells and/or neuroendocrine differentiation suggest that cancer stem cells play a role in the mechanisms of histological transformation and acquired resistance of ALK rearrangement-positive cancer. To our knowledge, this is the first report to suggest an association between cancer stem-like cells and histological transformation in ALK rearrangement-positive lung cancer.
    May 2019, Pathology international, 69(5) (5), 294 - 299, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Katsurada M, Nagano Tatsuya, Tachihara Motoko, Kiriu T, Furukawa K, Koyama K, Otoshi T, Sekiya R, Hazama D, Tamura D, Nakata K, Katsurada Naoko, Yamamoto Masatsugu, Kobayashi Kazuyuki, Nishimura Yoshihiro
    BACKGROUND/AIM: Immune checkpoint inhibitors (ICI) are a novel medication for non-small cell lung cancer (NSCLC). Recent reports indicated that baseline tumor size (BTS) relates to the efficacy of ICI therapy for melanoma, but no study exists for NSCLC. This study aimed to evaluate the utility of BTS for ICI therapy. PATIENTS AND METHODS: Data from 58 patients diagnosed with NSCLC who underwent ICI monotherapy, were retrospectively analyzed. Patients were divided into two groups according to BTS (below 101 mm, above 101 mm). The primary endpoint was progression-free survival (PFS) and the secondary endpoint was overall survival (OS). RESULTS: PFS of patients with a large BTS was significantly shorter than that of those with a small BTS (median; 2.07 [95% confidence interval [CI]=0.99-6.77] months versus 6.39 [95%CI=4.17-11.50] months) (p=0.044). OS of patients with large BTS was also significantly shorter (p<0.01). CONCLUSION: BTS is a predictive and prognostic negative factor of ICI therapy for NSCLC.
    Feb. 2019, Anticancer Res, 39(2) (2), 815 - 825, English, International magazine
    [Refereed]
    Scientific journal

  • 局所麻酔下胸腔鏡下生検で診断した肺癌肉腫の芽腫様亜型の1例
    堂國良太, Tachihara Motoko, 田村大介, 中田恭介, 堀朱矢, 山本正嗣, 上領博, 小林和幸, 西村善博
    (NPO)日本呼吸器内視鏡学会, Jan. 2019, 気管支学, 41(1) (1), 40 - 45, Japanese
    [Refereed]
    Scientific journal

  • Successful Treatment of ROS1-rearranged Lung Cancer Complicated by Hypertrophic Pulmonary Osteoarthropathy with Crizotinib Therapy: A Case Report
    Katsurada Naoko, Tachihara Motoko, Jimbo Naoe, Koyama K, Nakata K, Nagano Tatsuya, Yamamoto Masatsugu, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    Jan. 2019, Intern Med, English
    [Refereed]
    Scientific journal

  • Ogawa H, Tanaka Yugo, Tachihara Motoko, Uehara Keiichiro, Shimizu Nahoko, Doi T, Hokka Daisuke, Maniwa Yoshimasa
    ROS proto-oncogene 1 receptor tyrosine kinase (ROS1)-rearranged lung cancer is rare and comprises only 1% of lung adenocarcinoma cases. It has recently been reported to have good response to crizotinib, a tyrosine kinase inhibitor of anaplastic lymphoma kinase. Driver oncogene mutations with approved therapies seldom coexist with a high expression of Programmed death-ligand 1 (PD-L1). The present case report describes a rare case of ROS1 rearrangement with high-PD-L1-expressing occult lung adenocarcinoma. A 32-year-old woman presented with chest pain and a prolonged cough. Chest computed tomography (CT) revealed a 57×36-mm tumor in the mediastinum, with no tumors detected in other regions. Positron emission tomography (PET)-CT showed a strong fluorodeoxyglucose accumulation in the tumor (SUVmax 13.2). Mediastinal tumor resection was completely resected using a video-assisted thoracic surgery approach. Pathological examination showed the tumor cells were positive for thyroid transcription factor 1, Napsin-A, ROS1, and PD-L1 (tumor proportion score >99%). ROS1 rearrangement was confirmed by fluorescence in situ hybridization. The mediastinal tumor was diagnosed as mediastinal lymph node metastasis of ROS1-rearranged PD-L1 high-expression undifferentiated lung adenocarcinoma (pathological stage 3, TxN2M0). Two months after the operation, the CT scan showed multiple mediastinum lymph nodes metastases with rapid tumor growth. The patient achieved a complete response after three cycles of S-1 plus cisplatin with concurrent radiotherapy 60 Gy/30 Fr.
    Jan. 2019, Oncol Lett, 17(1) (1), 488 - 491, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Prognostic Value of Red Blood Cell Distribution Width in Non-small Cell Lung Cancer Treated With Anti-programmed Cell Death-1 Antibody
    Kiriu T, Yamamoto Masatsugu, Nagano Tatsuya, Koyama K, Katsurada M, Tamura D, Nakata K, Tachihara Motoko, Kobayashi Kazuyuki, Nishimura Yoshihiro
    Jan. 2019, In Vivo, 33(1) (1), 213 - 220, English
    [Refereed]
    Scientific journal

  • Non-parallel anti-tumour effects of pembrolizumab: a case of cardial tamponade
    Tachihara Motoko, Yamamoto Masatsugu, Yumura M, Yoshizaki A, Kobayashi Kazuyuki, Nishimura Yoshihiro
    Jan. 2019, Respirol Case Rep, 7(3) (3), e00404, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Phase II trial of gefitinib plus pemetrexed after relapse using first-line gefitinib in patients with non-small cell lung cancer harboring EGFR gene mutations
    Uchibori K, Satouchi M, Sueoka-Aragane N, Urata Y, Sato A, Imamura F, Inoue T, Tachihara Motoko, Kobayashi Kazuyuki, Katakami N, Kokan C, Hirashima T, Iwanaga K, Mori M, Aoe K, Morita S, Negoro S
    Oct. 2018, Lung Cancer, 124, 65 - 70, English
    [Refereed]
    Scientific journal

  • Efficacy of anti-PD-1/PD-L1 antibodies after discontinuation due to adverse events in non-small cell lung cancer patients (HANSHIN 0316)
    Tachihara Motoko, Negoro S, Inoue T, Tamiya M, Akazawa Y, Uenami T, Urata Y, Hattori Y, Hata A, Katakami N, Yokota S
    Oct. 2018, BMC CANCER, 18(1) (1), 946, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 寺下智美, Tachihara Motoko, 堂國良太, 吉崎飛鳥, 関谷怜奈, 田村大介, 山本正嗣, 上領博, 小林和幸, Nishimura Yoshihiro
    (NPO)日本呼吸器内視鏡学会, Mar. 2018, 気管支学, 40(2号) (2号), 163 - 167, Japanese
    [Refereed]
    Scientific journal

  • Bronchoscopy Using Virtual Navigation and Endobronchial Ultrasonography with a Guide Sheath (EBUS-GS) with or without Fluoroscopy for Peripheral Pulmonary Lesions
    Tachihara Motoko, Tamura D, Kiriu T, Tokunaga S, Hatakeyama Y, Shinke H, Nagano Tatsuya, Nakata K, Hazeki N, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    OBJECTIVE: Endobronchial ultrasonography and guide sheath (EBUS-GS) technique has high diagnostic yield in lung nodules. Virtual bronchoscopic navigation (VBN) can lead bronchoscope to the target bronchi. The aim of this prospective study was to compare the diagnostic yield of two bronchoscopic procedures: bronchoscopy under EBUS-GS and VBN with or without x-ray fluoroscopy in small peripheral pulmonary lesions (PPLs, ≤30mm) with apparent CT-bronchus sign. METHODS: 31 patients with PPLs which had apparent CT-bronchus sign were randomly assigned to the X-ray or the non-X-ray groups (18 with and 13 without fluoroscopy) between September 1, 2012, and September 30, 2015. A bronchoscope was introduced into the target bronchus using the VBN system. Sites of specimen sampling were verified using EBUS-GS with or without fluoroscopy. RESULTS: The overall diagnostic yield was 83.3% in the X-ray and 69.2% in the non-X-ray group. The diagnostic yield of malignancy was 88.2% and 81.8%, respectively. The duration of the examination and time elapsed until the first EBUS visualization were similar in the X-ray and the non-X-ray group (9.0 (5.8-20.) min vs 11.0 (5.3-17.3) min, and 2.5 (1.3-14.2) min vs 4.1 (1.4-8.1) min, respectively). The fluoroscopy exposure time was 3.7 (2.9-10.56) min. The only adverse event was mild pneumothorax in a patient from the non-X-ray group, who had consequent TBB under fluoroscopy. CONCLUSIONS: There was a possibility that VBN-guided EBUS-transbronchial diagnosis without fluoroscopy might be equivalent to that under fluoroscopy. Further multi-center randomized study may be desired. (UMIN000008592).
    Mar. 2018, Kobe J Med Sci, 63(4) (4), E99 - E104, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Tatsunori Kiriu, Masatsugu Yamamoto, Tatsuya Nagano, Daisuke Hazama, Reina Sekiya, Masahiro Katsurada, Daisuke Tamura, Motoko Tachihara, Kazuyuki Kobayashi, Yoshihiro Nishimura
    Public Library of Science, Feb. 2018, PLoS ONE, 13(2) (2), e0193018, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Tatsunori Kiriu, Daisuke Tamura, Motoko Tachihara, Reina Sekiya, Daisuke Hazama, Masahiro Katsurada, Kyosuke Nakata, Tatsuya Nagano, Masatsugu Yamamoto, Hiroshi Kamiryo, Kazuyuki Kobayashi, Yoshihiro Nishimura
    Japanese Society of Internal Medicine, 2018, Internal Medicine, 57(1) (1), 91 - 95, English
    [Refereed]
    Scientific journal

  • Kei Kunimasa, Tatsuya Nagano, Yohei Shimono, Ryota Dokuni, Tatsunori Kiriu, Shuntaro Tokunaga, Daisuke Tamura, Masatsugu Yamamoto, Motoko Tachihara, Kazuyuki Kobayashi, Miyako Satouchi, Yoshihiro Nishimura
    Jul. 2017, CANCER SCIENCE, 108(7) (7), 1368 - 1377, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Toshiaki Takahashi, Takeharu Yamanaka, Takashi Seto, Hideyuki Harada, Hiroshi Nokihara, Hideo Saka, Makoto Nishio, Hiroyasu Kaneda, Koichi Takayama, Osamu Ishimoto, Koji Takeda, Hiroshige Yoshioka, Motoko Tachihara, Hiroshi Sakai, Koichi Goto, Nobuyuki Yamamoto
    May 2017, LANCET ONCOLOGY, 18(5) (5), 663 - 671, English
    [Refereed]
    Scientific journal

  • Shuntaro Tokunaga, Tatsuya Nagano, Kazuyuki Kobayashi, Masahiro Katsurada, Kyosuke Nakata, Masatsugu Yamamoto, Motoko Tachihara, Hiroshi Kamiryo, Hiroshi Yokozaki, Yoshihiro Nishimura
    May 2017, ANTICANCER RESEARCH, 37(5) (5), 2225 - 2231, English
    [Refereed]
    Scientific journal

  • Nobuko Hazeki, Motoko Tachihara, Ryuko Tsukamoto, Shuntaro Tokunaga, Daisuke Tamura, Haruko Shinke, Kazuyuki Kobayashi, Yasuhiro Sakai, Yoshihiro Nishimura
    Elsevier B.V., Mar. 2017, Respiratory Investigation, 55(2) (2), 161 - 165, English
    [Refereed]
    Scientific journal

  • Motoko Tachihara, Yugo Tanaka, Yoh Zen, Yoshihiro Nishimura
    2017, INTERNAL MEDICINE, 56(21) (21), 2953 - 2954, English
    [Refereed]
    Scientific journal

  • Suya Hori, Motoko Tachihara, Daisuke Tamura, Kazuyuki Kobayashi, Kyosuke Nakata, Hiroshi Kamiryo, Yasuhiro Sakai, Tomoo Itoh, Takanori Hirose, Yoshihiro Nishimura
    2017, INTERNAL MEDICINE, 56(24) (24), 3333 - 3339, English
    [Refereed]
    Scientific journal

  • Allergic bronchopulmonary aspergillosis(ABPA)様の画像を呈したピーナッツ気管支異物の1例
    関谷怜奈, 小林和幸, 堂國良太, 羽間大祐, 桐生辰徳, 國政啓, 田村大介, Tachihara Motoko, Otera Hiroshi, 西村善博
    Nov. 2016, 気管支学, 38(6号) (6号), 515 - 520, Japanese
    [Refereed]
    Scientific journal

  • Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells
    TerashitaT, KobayashiK, Nagano Tatsuya, KawaY, TamuraD, Nakata Kyosuke, Yamamoto Masatsugu, Tachihara Motoko, Otera Hiroshi, Nishimura Yoshihiro
    Nov. 2016, Respir Res, 17(1) (1), 146, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takayuki Takahama, Kazuko Sakai, Masayuki Takeda, Koichi Azuma, Toyoaki Hida, Masataka Hirabayashi, Tetsuya Oguri, Hiroshi Tanaka, Noriyuki Ebi, Toshiyuki Sawa, Akihiro Bessho, Motoko Tachihara, Hiroaki Akamatsu, Shuji Bandoh, Daisuke Himeji, Tatsuo Ohira, Mototsugu Shimokawa, Yoichi Nakanishi, Kazuhiko Nakagawa, Kazuto Nishio
    Sep. 2016, ONCOTARGET, 7(36) (36), 58492 - 58499, English
    [Refereed]
    Scientific journal

  • Diagnostic utility of additional conventional techniques after endobronchial ultrasonography guidance during transbronchial biopsy
    KunimasaK, Tachihara Motoko, TamuraD, TokunagaS, Nakata Kyosuke, HazekiN, Otera Hiroshi, KobayashiK, SakaiY, Nishimura Yoshihiro
    Aug. 2016, Respirology, 21(6) (6), 1100 - 5, English
    [Refereed]
    Scientific journal

  • Naoko Fukuhara, Motoko Tachihara, Yoshinori Tanino, Junpei Saito, Suguru Sato, Takefumi Nikaido, Kenichi Misa, Atsuro Fukuhara, Xintao Wang, Takashi Ishida, Tetsuo Onami, Mitsuru Munakata
    Elsevier B.V., Mar. 2016, Respiratory Investigation, 54(2) (2), 109 - 115, English
    [Refereed]
    Scientific journal

  • A randomized phase II study of bevacizumab in combination with docetaxel or S-1 in patients with non-squamous non-small-cell lung cancer previously treated with platinum based chemotherapy (HANSHIN Oncology Group 0110)
    NishinoK, ImamuraF, KumagaiT, KatakamiN, HataA, OkudaC, UrataY, HattoriY, Tachihara Motoko, YokotaS, NishimuraT, KanedaT, SatouchiM, MoritaS, NegoroS
    Aug. 2015, Lung Cancer (Auckl), 89(2) (2), 146 - 53, English
    [Refereed]
    Scientific journal

  • Effectiveness of Tyrosine Kinase Inhibitors in Japanese Patients with Non-small Cell Lung Cancer Harboring Minor Epidermal Growth Factor Receptor Mutations: Results from a Multicenter Retrospective Study (HANSHIN Oncology Group 0212)
    OtsukaT, MoriM, YanoY, UchidaJ, NishinoK, KajiR, HataA, HattoriY, UrataY, KanedaT, Tachihara Motoko, ImamuraF, KatakamiN, NegoroS, MoritaS, YokotaS
    Jul. 2015, Anticancer Res, 35(7) (7), 3885 - 91, English
    [Refereed]
    Scientific journal

  • 寺下智美, Tachihara Motoko, 上原慶一郎, Sakai Yasuhiro, Nishimura Yoshihiro
    We report herein on a case of allergic bronchoalveolar aspergillosis (ABPA) with hyphae and Charcot-Leyden crystals against a necrotic background stained with Papanicolaou stain. Lung carcinoma was initially suspected before bronchoscopic brush cytology. Lung carcinoma or tuberculosis is sometimes suspected first in cases of aspergillosis. The pathological diagnosis is important because the seroprevalence and culture-positive rate are very low, and degenerated or vacuolated Aspergillus hyphae do not stain well with Papanicolaou stain. Careful observation of cytological specimens in a necrotic background is therefore required, considering the possibility of aspergillosis.
    The Japanese Society of Clinical Cytology, May 2015, 日本臨床細胞学会雑誌, 54(3号) (3号), 221 - 222, Japanese
    [Refereed]
    Scientific journal

  • A phase 2 study of bevacizumab in combination with carboplatin and paclitaxel in patients with non-squamous non-small-cell lung cancer harboring mutations of epidermal growth factor receptor (EGFR) after failing first-line EGFR-tyrosine kinase inhibitors
    Hattori Y, Satouchi M, Shimada T, Urata Y, Yoneda T, Mori M, Nishimura T, Sunadome H, Kumagai T, Imamura F, Fujita S, Kaji R, Hata A, Tachihara Motoko, Morita S, Negoro S
    Feb. 2015, Lung Cancer, 87(2) (2), 136 - 40, English
    [Refereed]
    Scientific journal

  • Virtual bronchoscopic navigation improves the diagnostic yield of radial-endobronchial ultrasound for peripheral pulmonary lesions with involved bronchi on CT
    AsanoF, ShinagawaN, IshidaT, TsuzukuA, Tachihara Motoko, KanazawaK, YamadaN, OizumiS, MoriyaH
    2015, Intern Med, 54(9) (9), 1021 - 5, English
    [Refereed]
    Scientific journal

  • Gradually Enlarging Crazy-paving Appearance
    KunimasaK, Tachihara Motoko, TerashitaT, Nishimura Yoshihiro
    2015, Intern Med, 54(21) (21), 2791 - 2, English
    [Refereed]
    Scientific journal

  • FDG-PETで両肺にびまん性異常集積を認めた血管内大細胞型B細胞リンパ腫(図説)
    阿部緑生, Tachihara Motoko, 植松学, 勝浦豊, 田中端子, 杉野隆, 小川一英
    2015, 臨床血液, 56, 749, Japanese
    [Refereed]
    Scientific journal

  • Successful crizotinib rechallenge after crizotinib-induced interstitial lung disease
    Tachihara Motoko, Kobayashi Kazuyuki, Ishikawa Y, Hori S, Tamura D, Otera Hiroshi, Funada Yasuhiro, Nishimura Yoshihiro
    Aug. 2014, Jpn J Clin Oncol, 44(8) (8), 762 - 4, English
    [Refereed]
    Scientific journal

  • Ground glass opacity(GGO)主体肺末梢病変のendobronchial ultrasonography(EBUS)像について
    須甲 憲明, 品川 尚文, 池澤 靖元, 中野 浩輔, 福元 伸一, Tachihara Motoko, 磯部 宏, 西村 正治, 原田 真雄
    May 2014, 気管支学, 36(3号) (3号), 298 - 303, Japanese
    [Refereed]
    Scientific journal

  • Synergistic effects of pemetrexed and amrubicin in non-small cell lung cancer cell lines: Potential for combination therapy
    Hatakeyama Y, Kobayashi Kazuyuki, Nagano T, Tamura D, Yamamoto M, Tachihara Motoko, Kotani Yoshikazu, Nishimura Yoshihiro
    Feb. 2014, Cancer Lett, 343(1) (1), 74 - 9, English
    [Refereed]
    Scientific journal

  • EGFR-TKIによるざ瘡様皮疹に対しアダパレンが有効であった2例 Successful Treatment with Adapalene for EGFR-TKI-induced Acneiform Eruptions
    Tachihara Motoko, 徳永 俊太郎, 田村 大介, 小林 和幸, 船田 泰弘, 西村 善博
    2014, 肺癌, 54(7) (7), 978 - 982, Japanese
    [Refereed]
    Scientific journal

  • Tachihara Motoko, 田村 大介, 畠山 由記久, 新家 治子, 堀 朱矢, 石川 結美子, 櫨木 暢子, 小林 和幸, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro
    Background. The utility of the virtual bronchoscopic navigation system (VBN) for small peripheral pulmonary lesions is widely known. However, applications of VBN as a guide for diagnosing mediastinal or hilar lesions have yet to be reported. Case. A 49-year-old woman consulted a local doctor with dyspnea on exertion. Chest computed tomography (CT) showed tumor adjacent to the left pulmonary artery. She was referred to our hospital, where she subsequently underwent bronchoscopy. Tumor was not visible on bronchoscopy, so we performed transbronchial needle aspiration (TBNA) of B^<1+2>c; however, no tumor could be diagnosed. TBNA of the upper dorsal B^<1+2>a inlet was then performed under VBN guidance. Histopathological examination revealed mucosa-associated lymphoid tissue (MALT) lymphoma of the lung. Conclusion. Conventional TBNA for mediastinal and hilar lesions is a fairly blind technique that does not allow visualization of the target. We suggest that TBNA under VBN guidance is an effective diagnostic approach for mediastinal and hilar lesions.
    The Japan Society for Respiratory Endoscopy, Nov. 2013, 気管支学, 35(6号) (6号), 671 - 676, Japanese
    [Refereed]
    Scientific journal

  • Randomized phase II trial of uracil/tegafur and cisplatin versus vinorelbine and cisplatin with concurrent thoracic radiotherapy for locally advanced unresectable stage III non-small-cell lung cancer: NJLCG 0601
    Sugawara S, Maemondo M, Tachihara Motoko, Inoue A, Ishimoto O, Sakakibara T, Usui K, Watanabe H, Matsubara N, Watanabe K, Kanazawa K, Ishida T, Saijo Y, Nukiwa T, North Japan Lung Cancer, Study Group
    Jul. 2013, Lung Cancer, 81(1) (1), 91 - 6, English
    [Refereed]
    Scientific journal

  • 当科における傍腫瘍性神経症候群合併小細胞肺癌の臨床的検討
    Tachihara Motoko, Tamura Daisuke, Kasai Daisuke, Funada Yasuhiro, Kotani Yoshikazu, Sakai Yasuhiro, Ohno Yoshiharu, Maniwa Yoshimasa, Nishimura Yoshihiro
    Oct. 2012, 肺癌, 52(5号) (5号), 724, Japanese
    Research society

  • Four cases of Trousseau's syndrome associated with lung adenocarcinoma
    Tachihara Motoko
    Sep. 2012, Intern Med, 51(9) (9), 1099 - 102, English
    [Refereed]
    Scientific journal

  • 肺内転移やリンパ節転移との鑑別が困難であった扁平上皮腺上皮性混合型乳頭腫の1例
    Nakai Tokiko, Sakai Yasuhiro, Ohbayashi Chiho, Nishio Mizuho, Koyama Hisanobu, Ohno Yoshiharu, Tachihara Motoko, Sakashita Akihiro, Kasai Daisuke, Kobayashi Kazuyuki, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro, Hokka Daisuke, Maniwa Yoshimasa, Nishio Wataru
    (NPO)日本肺癌学会, Jun. 2012, 肺癌, 52(3) (3), 353 - 354, Japanese
    Research society

  • Bf-NAVI併用によるTBNAにて確定診断しえた肺MALT Lymphomaの一症例
    Tamura Daisuke, Tachihara Motoko, Kobayashi Kazuyuki, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro
    May 2012, 気管支学, 34(Suppl.) (Suppl.), S226, Japanese
    Research society

  • 集検喀痰細胞診で発見された喉頭癌と早期中心型肺癌の細胞像の比較検討
    Tachihara Motoko
    Jan. 2012, 日本臨床細胞学会雑誌, 51巻, 1号, pp. 7-12, Japanese
    [Refereed]
    Scientific journal

  • 局所再発を繰り返し、外科切除にて混合型小細胞肺癌と診断した1例
    Tachihara Motoko
    Dec. 2011, 肺癌, 51巻, 7号, pp. 820-824, Japanese
    [Refereed]
    Scientific journal

  • Increase of ascites and pleural effusion misleading assessment of antitumor response to erlotinib in adenocarcinoma of the lung
    Tachihara Motoko
    Aug. 2011, Journal of clinical oncology, Vol. 29, No. 23, pp. e675-7, English
    Scientific journal

  • Tachihara Motoko, 石田 卓, 二階堂 雄文, 猪腰 弥生, 齋藤 香恵, 仲川 奈緒子, 福原 敦朗, 関根 聡子, 石井 妙子, 大島 謙吾, 佐藤 俊, 菅原 綾, 渡辺 香奈, 金沢 賢也, 齋藤 純平, 谷野 功典, 棟方 充
    Background. Bronchoscopic examination by endobronchial ultrasonography with a guide sheath (EBUS-GS) is becoming more common in the diagnosis of peripheral pulmonary lesions. However, no standards have been established for the order in which bronchial brushing and transbronchial biopsy are performed in bronchoscopy with EBUS-GS. Objective. This prospective bronchoscopic study by EBUS-GS examined whether bronchial brushing or transbronchial biopsy should be performed first, by comparing diagnostic accuracy. Subjects and Methods. Lesions that were visualized on EBUS images and were subjected to bronchial brushing and transbronchial biopsy were analyzed. The order of specimen collection was divided into 2 periods: brushing followed by biopsy (from June 1, 2007 to March 31, 2008; cohort A) or biopsy followed by brushing (from April 1, 2008 to January 31, 2009; cohort B). Diagnostic accuracy was assessed. We also evaluated whether the order of specimen collection affected proper specimen preparation in brushing cytology. Results. In cohort A, EBUS-GS was used in 81 lesions, and 72 lesions were visualized on EBUS (EBUS visualization rate, 88.9%). Both brushing and biopsy were performed for 69 lesions. In cohort B, EBUS-GS was used in 71 lesions, and 68 lesions were visualized (95.8%); both brushing and biopsy were performed for 66 lesions. The mean maximum diameter was 28.6mm for both cohorts A and B. Diagnostic accuracy for all 135 lesions was 83.0% (112/135 lesions), and diagnostic accuracy for all malignancies was 90.8% (108/119 lesions). For the 119 malignant lesions, diagnostic accuracies of biopsy, brushing, and the 2 procedures combined were 77.2%, 78.9% and 87.7%, respectively in cohort A and 85.5%, 87.1% and 93.5%, respectively in cohort B. There was no significant difference between the cohorts. Moreover, the order of specimen collection had no effect on specimen preparation for cytology. Conclusion. In bronchoscopic examination with EBUS-GS, as long as lesions can be visualized by EBUS, the order of brushing and biopsy does not affect diagnostic accuracy.
    The Japan Society for Respiratory Endoscopy, Sep. 2010, 気管支学, 32(5号) (5号), 395 - 401, Japanese
    [Refereed]
    Scientific journal

■ MISC
  • Nagano Tatsuya, Tachihara Motoko, Nishimura Yoshihiro
    Lung cancer is the leading cause of cancer death worldwide. Molecular targeted therapy has greatly advanced the field of treatment for non-small cell lung cancer (NSCLC), which accounts for the majority of lung cancers. Indeed, gefitinib, which was the first molecular targeted therapeutic agent, has actually doubled the survival time of NSCLC patients. Vigorous efforts of clinicians and researchers have revealed that lung cancer develops through the activating mutations of many driver genes including the epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), v-Raf murine sarcoma viral oncogene homolog B (BRAF), and rearranged during transfection (RET) genes. Although ALK, ROS1, and RET are rare genetic abnormalities, corresponding tyrosine kinase inhibitors (TKIs) can exert dramatic therapeutic effects. In addition to anticancer drugs targeting driver genes, bevacizumab specifically binds to human vascular endothelial growth factor (VEGF) and blocks the VEGF signaling pathway. The VEGF signal blockade suppresses angiogenesis in tumor tissues and inhibits tumor growth. In this review, we also explore immunotherapy, which is a promising new NSCLC treatment approach. In general, antitumor immune responses are suppressed in cancer patients, and cancer cells escape from the immune surveillance mechanism. Immune checkpoint inhibitors (ICIs) are antibodies that target the primary escape mechanisms, immune checkpoints. Patients who respond to ICIs are reported to experience longlasting therapeutic effects. A wide range of clinical approaches, including combination therapy involving chemotherapy or radiation plus adjuvant therapy, are being developed.
    Dec. 2018, Curr Cancer Drug Targets, 19(8) (8), 595 - 630, English, International magazine
    [Refereed]
    Introduction scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Nagano Tatsuya, Tachihara Motoko, Nishimura Yoshihiro
    Treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) improves the overall survival of patients with EGFR-mutated non-small-cell lung cancer (NSCLC). First-generation EGFR-TKIs (e.g., gefitinib and erlotinib) or second-generation EGFR-TKIs (e.g., afatinib and dacomitinib) are effective for the treatment of EGFR-mutated NSCLC, especially in patients with EGFR exon 19 deletions or an exon 21 L858R mutation. However, almost all cases experience disease recurrence after 1 to 2 years due to acquired resistance. The EGFR T790M mutation in exon 20 is the most frequent alteration associated with the development of acquired resistance. Osimertinib-a third-generation EGFR-TKI-targets the T790M mutation and has demonstrated high efficacy against EGFR-mutated lung cancer. However, the development of acquired resistance to third-generation EGFR-TKI, involving the cysteine residue at codon 797 mutation, has been observed. Other mechanisms of acquired resistance include the activation of alternative pathways or downstream targets and histological transformation (i.e., epithelial⁻mesenchymal transition or conversion to small-cell lung cancer). Furthermore, the development of primary resistance through overexpression of the hepatocyte growth factor and suppression of Bcl-2-like protein 11 expression may lead to problems. In this report, we review these mechanisms and discuss therapeutic strategies to overcome resistance to EGFR-TKIs.
    Nov. 2018, Cells, 7(11) (11), English, International magazine
    [Refereed]
    Introduction scientific journal
    Link to Kobe Univ. Repository (Kernel)

■ Lectures, oral presentations, etc.
  • 免疫チェックポイント阻害薬で治療したPD-L1陽性肺癌に対する好中球リンパ球比の検討
    桐生辰徳, YAMAMOTO MASATSUGU, 小山貴与子, 羽間大祐, 関谷怜奈, 桂田雅大, KATSURADA NAOKO, NAKATA KYOSUKE, NAGANO TATSUYA, 田村大介, TACHIHARA MOTOKO, KOBAYASHI KAZUYUKI, NISHIMURA YOSHIHIRO
    第58回 日本肺癌学会学術集会, Nov. 2018, Japanese, 横浜, Domestic conference
    Oral presentation

  • 免疫チェックポイント阻害剤投与例における赤血球容積粒度分布幅の有用性
    桐生辰徳, YAMAMOTO MASATSUGU, 小山貴与子, 羽間大祐, 関谷怜奈, 桂田雅大, KATSURADA NAOKO, NAKATA KYOSUKE, NAGANO TATSUYA, 田村大介, TACHIHARA MOTOKO, KOBAYASHI KAZUYUKI, NISHIMURA YOSHIHIRO
    第59回 日本肺癌学会学術集会, Nov. 2018, Japanese, 横浜, Domestic conference
    Oral presentation

  • 無症候性脳転移を有する非小細胞肺癌に対するシスプラチン+ペメトレキセド+ベバシズマブの第II相試験
    熊谷融, 秦明登, 河良崇, 内田純二, 桐生辰徳, YAMAMOTO MASATSUGU, TACHIHARA MOTOKO, 高瀬直人, 金田俊彦, 片上信之, 根來俊一, 横田総一郎
    第60回 日本肺癌学会学術集会, Nov. 2018, Japanese, 横浜, Domestic conference
    Oral presentation

  • 間質性陰影合併肺癌における抗PD-1抗体による間質性陰影増悪のリスク因子の検討
    小山貴与子, TACHIHARA MOTOKO, 桐生辰徳, 桂田雅大, KATSURADA NAOKO, 田村大介, NAGANO TATSUYA, NAKATA KYOSUKE, YAMAMOTO MASATSUGU, KOBAYASHI KAZUYUKI, NISHIMURA YOSHIHIRO
    第61回 日本肺癌学会学術集会, Nov. 2018, Japanese, 横浜, Domestic conference
    Oral presentation

  • Gemcitabine enhances anti-tumor activity of Paclitaxel by Modulating Tubulin Acetylation
    Wiwin Is Effendi, Tatsuya Nagano, Motoko Tachihara, Kanoko Umezawa, Ryota Dokuni, Tatsunori Kiriu, Masahiro Katsurada, Masatsugu Yamamoto, Kazuyuki Kobayashi, Yoshihiro Nishimura
    Asian Pacific Society of Respirology 2018, Nov. 2018, English, Taipei, International conference
    Oral presentation

  • Xenon Ventilation Computed Tomography and Bronchial Thermoplasty for Asthma
    Ryota Dokuni, Kazuyuki Kobayashi, Yoshiharu Ohno, Tatsuya Nagano, Daisuke Tamura, Kanoko Umezawa, Naoko Katsurada, Kyosuke Nakata, Masatsugu Yamamoto, Motoko Tachihara, Hiroshi Kamiryo, Yoshihiro Nishimura
    24th World Asthma Congress 2018, Oct. 2018, English, INTERASTHMA Globa Asthma Association, Tokyo, International conference
    Oral presentation

  • 多発神経炎の発症に，腫瘍由来の自己抗体の関与が疑われた肺小細胞肺癌の1例
    長妻 渉, YAMAMOTO MASATSUGU, 玉田 敏也, 湯村 真沙子, KATSURADA NAOKO, NAKATA KYOSUKE, TACHIHARA MOTOKO, KAMIRYO HIROSHI, KOBAYASHI KAZUYUKI, NISHIMURA YOSHIHIRO
    第221回 日本内科学会 近畿地方会, Sep. 2018, Japanese, 大阪, Domestic conference
    Oral presentation

  • ペムブロリズマブ投与後に免疫関連胆管炎を発症した肺腺癌の1例
    河内 啓貴, YAMAMOTO MASATSUGU, 玉田 敏也, 湯村 真沙子, KATSURADA NAOKO, NAKATA KYOSUKE, TACHIHARA MOTOKO, KAMIRYO HIROSHI, KOBAYASHI KAZUYUKI, NISHIMURA YOSHIHIRO
    第221回 日本内科学会 近畿地方会, Sep. 2018, Japanese, 大阪, Domestic conference
    Oral presentation

  • Nab-paclitaxel plus gemcitabine in advanced NSCLC after platinum-based chemotherapy: final results and caveolin-1 expression
    Tatsunori Kiriu, Motoko Tachihara, Akito Hata, Yukihisa Hatakeyama, Tatsuya Nagano, Masatsugu Yamamoto, Kazuyuki Kobayashi, Hisashi Ohnishi, Nobuyuki Katakami, Yoshihiro Nishimura
    19th world conference on lung cancer, Sep. 2018, English, Toronto, International conference
    Oral presentation

  • 無症候性脳転移を有する非扁平上皮非小細胞肺癌に対する初回治療のシスプラチン＋ペメトレキセド＋ベバシズマブの第II相試験
    河 良崇, 秦 明登, 熊谷 融, 内田 純二, 桐生 辰徳, YAMAMOTO MASATSUGU, TACHIHARA MOTOKO, 高瀬 直人, 金田 俊彦, 片上 信之, 根来 俊一, 横田 総一郎
    第16回 日本臨床腫瘍学会学術集会, Jul. 2018, Japanese, 神戸, Domestic conference
    Oral presentation

  • 非小細胞肺癌（非扁平上皮癌）完全切除症例に対するCDDP+PEMショートハイドレーション療法による術後補助化学療法の認容性試験
    奥野 恵子, TACHIHARA MOTOKO, 徳永 俊太郎, 堂國 良太, KATSURADA NAOKO, NAKATA KYOSUKE, YAMAMOTO MASATSUGU, KAMIRYO HIROSHI, KOBAYASHI KAZUYUKI, TANAKA YUGO, 船田 泰弘, MANIWA YOSHIMASA, NISHIMURA YOSHIHIRO
    第16回 日本臨床腫瘍学会学術集会, Jul. 2018, Japanese, 神戸, Domestic conference
    Oral presentation

  • プラチナ製剤無効後の既治療非小細胞肺癌患者に対するweekly Nab-paclitaxelとGemcitabine併用療法の第II相試験
    秦 明登, TACHIHARA MOTOKO, 畠山 由記久, 桐生 辰徳, NAGANO TATSUYA, YAMAMOTO MASATSUGU, KOBAYASHI KAZUYUKI, 大西 尚, 片上 信之, NISHIMURA YOSHIHIRO
    第16回 日本臨床腫瘍学会学術集会, Jul. 2018, Japanese, 神戸, Domestic conference
    Oral presentation

  • アレクチニブによる治療中に神経内分泌癌へ形質転換したと考えられたALK融合遺伝子陽性肺腺癌の一例
    小山貴与子, KATSURADA NAOKO, NAKATA KYOSUKE, 田村大介, NAGANO TATSUYA, YAMAMOTO MASATSUGU, TACHIHARA MOTOKO, KAMIRYO HIROSHI, KOBAYASHI KAZUYUKI, NISHIMURA YOSHIHIRO, JIMBO NAOE
    第91回 日本呼吸器学会, Jul. 2018, Japanese, 神戸, Domestic conference
    Oral presentation

  • 肺性肥大性骨関節症を合併したROS1融合遺伝子陽性肺癌の一例
    KATSURADA NAOKO, 小山貴与子, NAKATA KYOSUKE, YAMAMOTO MASATSUGU, TANAKA YUGO, TACHIHARA MOTOKO, KAMIRYO HIROSHI, MANIWA YOSHIMASA, NISHIMURA YOSHIHIRO
    第108回肺癌学会関西支部会, Jun. 2018, Japanese, 大阪, Domestic conference
    Oral presentation

  • Adapalene gel 0.1% vs. placebo as prophylaxis for anti-EGFR-induced acne-like rash: a randomized left-right comparative evaluation (APPEARANCE)
    Motoko Tachihara, Naoko Chayahara, Yoshimi Fujishima, Atsushi Fukunaga, Ken Washio, Masatsugu Yamamoto, Kyosuke Nakata, Kazuyuki Kobayashi, Kei Takenaka, Masanori Toyoda, Naomi Kiyota, Kazutoshi Tobimatsu, Hisayo Doi, Naomi Mizuta, Naho Marugami, Atsushi Kawaguchi, Chikako Nishigori, Yoshihiro Nishimura, Toru Mukohara, Hironobu Minami
    American Society of Clinical Oncology Annual Meeting 2018, Jun. 2018, English, Chicago, International conference
    Poster presentation

  • 当科における気管支鏡検査後に発症した呼吸器感染症の検討
    KATSURADA NAOKO, TACHIHARA MOTOKO, 小山貴与子, 湯村真沙子, 吉崎 飛鳥, 堂國 良太, 安田裕一郎, 桐生 辰徳, UMEZAWA KANOKO, 寺下 智美, 関谷 怜奈, 桂田 雅大, 田村 大介, YAMAMOTO MASATSUGU, KAMIRYO HIROSHI, KOBAYASHI KAZUYUKI, NISHIMURA YOSHIHIRO
    第41回日本呼吸器内視鏡学会学術集会, May 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 当科におけるEBUS-TBNA検査の実態に関する検討
    田村大介, TACHIHARA MOTOKO, 小山貴与子, 湯村真沙子, 吉崎飛鳥, 安田裕一郎, 堂國良太, 桐生辰徳, UMEZAWA KANOKO, 寺下智美, 関谷玲奈, 桂田雅大, KATSURADA NAOKO, YAMAMOTO MASATSUGU, KAMIRYO HIROSHI, KOBAYASHI KAZUYUKI, NISHIMURA YOSHIHIRO
    第41回日本呼吸器内視鏡学会学術集会, May 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 連続パルスオキシメトリーによる在宅酸素療法患者の夜間低酸素血症の調査
    吉崎 飛鳥, NAGANO TATSUYA, 船田 泰弘, NAKATA KYOSUKE, 西馬 照明, 高月 清宣, 大西 尚, 櫨木 暢子, 堂國 良太, KATSURADA NAOKO, TACHIHARA MOTOKO, KAMIRYO HIROSHI, KOBAYASHI KAZUYUKI, NISHIMURA YOSHIHIRO
    第58回日本呼吸器学会学術講演会, Apr. 2018, Japanese, 大阪, Domestic conference
    Poster presentation

  • Feasibility study of adjuvant chemotherapy with cisplatin and pemetrexed short hydration regimen for completely resected non-small cell lung cancer
    Ryota Dokuni, Motoko Tachihara, Shuntaro Tokunaga, Keiko Okuno, Masatsugu Yamamoto, Kazuyuki Kobayashi, Yugo Tanaka, Yasuhiro Funada, Yoshimasa Maniwa, Yoshihiro Nishimura
    European Lung Cancer Congress 2018, Apr. 2018, English, Geneva, International conference
    Oral presentation

  • A Phase II Trial of Nab-Paclitaxel and Gemcitabine in Patients with Non-Small-Cell Lung Cancer Previously Treated with Platinum Based Chemotherapy
    Yukihisa Hatakeyama, Motoko Tachihara, Tatsunori Kiriu, Akito Hata, Tatsuya Nagano, Masatsugu Yamamoto, Kazuyuki Kobayashi, Hisashi Ohnishi, Nobuyuki Katakami, Yoshihiro Nishimura
    European Lung Cancer Congress 2018, Apr. 2018, English, Geneva, International conference
    Oral presentation

  • 化学療法により症状の改善を認めたLambert-Eaton症候群合併肺小細胞癌の1例
    高木泰尚, 小山貴与子, 寺下智美, Nakata Kyosuke, Nagano Tatsuya, Yamamoto Masatsugu, Tachihara Motoko, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第90回日本呼吸器学会近畿地方会, Dec. 2017, Japanese, 日本呼吸器学会, 大阪, Domestic conference
    Poster presentation

  • Nivolumab投与例における末梢血好中球/リンパ球比(NLR)の変化とその有用性
    桐生辰徳, Yamamoto Masatsugu, Nagano Tatsuya, 羽間大祐, 桂田雅大, 田村大介, Tachihara Motoko, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第58回日本肺癌学会学術集会, Oct. 2017, Japanese, 日本肺癌学会, 横浜, Domestic conference
    Oral presentation

  • The clinical survey of lettuce-associated respiratory symptoms
    Reina Sekiya, Nagano Tatsuya, Haruko Shinke, Nakata Kyosuke, Masastugu Yamamoto, Tachihara Motoko, Hiroshi Kamiryo, Kobayashi Kazuyuki, Nishimura Yoshihiro
    27 th ERS international congress, Sep. 2017, English, European Respiratory Society, ミラノ, イタリア, International conference
    Poster presentation

  • Nivolumab 投与後に腱鞘炎，多発関節炎を発症した肺腺癌の1例
    古屋誠彦, 尾野慶彦, 吉崎飛鳥, Nakata Kyosuke, Yamamoto Masatsugu, Tachihara Motoko, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第89回日本呼吸器学会近畿地方会, Jul. 2017, Japanese, 日本呼吸器学会, 大阪, Domestic conference
    Oral presentation

  • HDR症候群に肺扁平上皮癌を発症した1例
    小嶋真理子, Nagano Tatsuya, Nakata Kyosuke, Yamamoto Masatsugu, Tachihara Motoko, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第216回日本内科学会近畿地方会, Jul. 2017, Japanese, 日本内科学会, 大阪, Domestic conference
    Oral presentation

  • 閉塞性睡眠時無呼吸症候群における減量とAHIの改善
    関谷怜奈, Nagano Tatsuya, Yamamoto Masatsugu, Nakata Kyosuke, Yamamoto Masatsugu, Tachihara Motoko, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    日本睡眠学会第42回定期学術集会, Jun. 2017, Japanese, 日本睡眠学会, 横浜, Domestic conference
    Poster presentation

  • 当科の非小細胞肺癌に対するニボルマブの治療成績に関する検討
    桂田雅大, Tachihara Motoko, 桐生辰徳, Nagano Tatsuya, 田村大介, Nakata Kyosuke, Yamamoto Masatsugu, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第106回日本肺癌学会関西支部学術集会, Jun. 2017, Japanese, 日本肺癌学会, 大阪, Domestic conference
    Poster presentation

  • JTE013による気道上皮を介した喘息の抑制作用
    寺下智美, Nagano Tatsuya, Kobayashi Kazuyuki, 河良崇, 田村大介, Nakata Kyosuke, Yamamoto Masatsugu, Tachihara Motoko, Otera Hiroshi, Nishimura Yoshihiro
    第66回日本アレルギー学会学術大会, Jun. 2017, Japanese, 日本アレルギー学会, 東京, Domestic conference
    Oral presentation

  • EGFR遺伝子変異陽性肺癌における気管支鏡での再生検についての検討
    Tachihara Motoko, Yamamoto Masatsugu, 寺下智美, 田村大介, 吉崎飛鳥, 川本めぐみ, 羽間大祐, 堂國良太, 桐生辰徳, 関谷怜奈, 桂田雅大, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第40回日本呼吸器内視鏡学会学術集会, Jun. 2017, Japanese, 日本呼吸器内視鏡学会, 長崎, Domestic conference
    Oral presentation

  • EBUS-GS後のTBAC追加による末梢肺病変診断への有用性に関する検討
    桂田雅大, Tachihara Motoko, 吉崎飛鳥, 川本めぐみ, 羽間大祐, 堂國良太, 桐生辰徳, 寺下智美, 関谷怜奈, 田村大介, Yamamoto Masatsugu, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第40回日本呼吸器内視鏡学会学術集会, Jun. 2017, Japanese, 日本呼吸器内視鏡学会, 長崎, Domestic conference
    Oral presentation

  • 当科でのEGFR遺伝子変異陽性肺癌における再生検についての検討
    小嶋 真理子, Yamamoto Masatsugu, 桐生 辰徳, 羽間 大祐, 関谷 怜奈, 桂田 雅大, 田村 大介, Nakata Kyosuke, Nagano Tatsuya, Tachihara Motoko, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第105回日本肺癌学会関西支部学術集会, Jan. 2017, Japanese, 日本肺癌学会, 大阪, Domestic conference
    Oral presentation

  • オシメルチニブに起因する薬剤性間質性肺炎発症後にステロイド内服下でのオシメルチニブ再投与が奏功した一例
    桂田 雅大, 田村 大介, 吉崎 飛鳥, 尾野 慶彦, 桐生 辰徳, Nagano Tatsuya, Nakata Kyosuke, Yamamoto Masatsugu, Tachihara Motoko, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第105回日本肺癌学会関西支部学術集会, Jan. 2017, Japanese, 日本肺癌学会, 大阪, Domestic conference
    Poster presentation

  • 病因と考えられる肺炎を確認できたSwyer-James症候群の一例
    小濱 みずき, Kobayashi Kazuyuki, Yamamoto Masatsugu, 吉崎 飛鳥, 尾野 慶彦, 桐生 辰徳, 田村 大介, Nakata Kyosuke, Nagano Tatsuya, Tachihara Motoko, Otera Hiroshi, Nishimura Yoshihiro
    第88回日本呼吸器学会近畿地方会, Dec. 2016, Japanese, 日本呼吸器学会, 京都, Domestic conference
    Oral presentation

  • 肺移植後の経過でアスペルギルス症による喀血をきたした肺リンパ脈管筋腫症の一例
    津田 悠三, Kobayashi Kazuyuki, Yamamoto Masatsugu, 吉崎 飛鳥, 尾野 慶彦, 田村 大介, Nakata Kyosuke, Nagano Tatsuya, Tachihara Motoko, Nishimura Yoshihiro
    第88回日本呼吸器学会近畿地方会, Dec. 2016, Japanese, 日本呼吸器学会, 京都, Domestic conference
    Oral presentation

  • 全身PET/MRI、MRI、PET/CT及び通常画像検査における胸腺上皮性腫瘍の病期診断能の比較
    Ohno Yoshiharu, 岸田 雄二, Seki Shinichiro, Yoshikawa Takeshi, 田村 大介, Tanaka Yugo, Tachihara Motoko, Kobayashi Kazuyuki, Sakai Yasuhiro, Maniwa Yoshimasa, Nishimura Yoshihiro
    第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference
    Oral presentation

  • 次元CTコンピューター体積測定システムの臨床応用 経過観察CTによる良・悪性結節鑑別能評価
    Ohno Yoshiharu, 岸田 雄二, Seki Shinichiro, Yoshikawa Takeshi, 田村 大介, Tanaka Yugo, Tachihara Motoko, Kobayashi Kazuyuki, Sakai Yasuhiro, Maniwa Yoshimasa, Nishimura Yoshihiro
    第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference
    Oral presentation

  • 3次元肺癌CT検診用コンピューター支援診断システムの低線量化における再構成の影響に関する比較検討
    Ohno Yoshiharu, 岸田 雄二, Seki Shinichiro, Yoshikawa Takeshi, 田村 大介, Tanaka Yugo, Tachihara Motoko, Kobayashi Kazuyuki, Sakai Yasuhiro, Maniwa Yoshimasa, Nishimura Yoshihiro
    第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference
    Oral presentation

  • 3次元 CTコンピューター体積測定システムの臨床応用：経過観察CTによる良・悪性結節鑑別能評価
    Ohno Yoshiharu, 岸田 雄二, Seki Shinichiro, Yoshikawa Takeshi, 田村 大介, 田中 雄吾, Tachihara Motoko, Kobayashi Kazuyuki, Sakai Yasuhiro, Maniwa Yoshimasa, Nishimura Yoshihiro
    第57回日本肺癌学会学術集会, Dec. 2016, Japanese, 日本肺癌学会, 福岡, Domestic conference
    Poster presentation

  • 胸水貯留で発症したIgG4関連肺疾患の1例
    矢谷 敦彦, Kobayashi Kazuyuki, Yamamoto Masatsugu, 吉崎 飛鳥, 尾野 慶彦, Nagano Tatsuya, Nakata Kyosuke, Tachihara Motoko, Otera Hiroshi, Nishimura Yoshihiro
    第214回日本内科学会近畿地方会, Nov. 2016, Japanese, 日本内科学会, 大阪, Domestic conference
    Oral presentation

  • Outcomes of Sequential Chemoradiotherapy for Small-Cell Lung Cancer in Patients Unsuitable for CCRT
    Hiroki Kawaguchi, Ejima Yasuo, Ishihara Takeaki, Miyawaki Daisuke, Yoshida Kenji, Tachihara Motoko, Daisuke Tamura, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Poster presentation

  • 潰瘍性大腸炎に合併した大腸転移を伴う小細胞肺癌の一例
    松本 学, 桐生 辰徳, 羽間 大祐, Nakata Kyosuke, 田村 大介, 櫨木 暢子, Tachihara Motoko, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第104回日本肺癌学会関西支部学術集会, Jul. 2016, Japanese, 日本肺癌学会, 大阪, Domestic conference
    Oral presentation

  • 大腸がん合併肺腫瘍の検討
    國政 啓, Tachihara Motoko, 梅澤 佳乃子, 三輪 菜々子, 田村 大介, Nakata Kyosuke, 櫨木 暢子, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第14回日本臨床腫瘍学会学術集会, Jul. 2016, Japanese, 日本臨床腫瘍学会, 神戸, Domestic conference
    Poster presentation

  • 気管支鏡により診断しえた炎症性筋線維芽細胞腫の一例
    堂國 良太, Nakata Kyosuke, 田村 大介, Nagano Tatsuya, Yamamoto Masatsugu, Tachihara Motoko, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第99回日本呼吸器内視鏡学会近畿支部会, Jul. 2016, Japanese, 日本呼吸器内視鏡学会, 大阪, Domestic conference
    Oral presentation

  • 悪性黒色腫の肺転移と思われた1例
    Jimbo Naoe, 大谷 恭子, Sakai Yasuhiro, 川本 めぐみ, 羽間 大祐, 堂國 良太, 吉崎 飛鳥, 桐生 辰徳, 関谷 怜奈, 寺下 智美, 梅澤 佳乃子, 尾野 慶彦, 三輪 菜々子, 桂田 雅大, 徳永 俊太郎, 桂田 直子, 田村 大介, Nagano Tatsuya, Nakata Kyosuke, Yamamoto Masatsugu, Tachihara Motoko, Kobayashi Kazuyuki, Nishimura Yoshihiro, 酒井 秀都, 内田 孝宏, 金 泰雄, 木村 賢司, Shimizu Nahoko, Ogawa Hiroyuki, 法華 大介, Tanaka Yugo, Maniwa Yoshimasa, Ohno Yoshiharu
    第104回日本肺癌学会関西支部会, Jul. 2016, Japanese, 日本肺癌学会, 大阪, Domestic conference
    Poster presentation

  • アファチニブ初回治療耐性後に再生検を施行した症例の検討
    Tachihara Motoko, 田村 大介, Sakai Yasuhiro, 桐生 辰徳, 堂國 良太, 羽間 大祐, Nakata Kyosuke, Nagano Tatsuya, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第14回日本臨床腫瘍学会学術集会, Jul. 2016, Japanese, 日本臨床腫瘍学会, 神戸, Domestic conference
    Poster presentation

  • 小型末梢肺病変に対するEBUS-GSとVBN併用下でX線透視の必要性に関する検討
    桐生 辰徳, Tachihara Motoko, 堂國 良太, 羽間 大祐, 関谷 怜奈, 梅澤 佳乃子, 西村 春佳, 國政 啓, 德永 俊太郎, 堀 朱矢, 新家 治子, 田村 大介, 櫨木 暢子, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第39回日本呼吸器内視鏡学会学術集会, Jun. 2016, Japanese, 日本呼吸器内視鏡学会, 名古屋, Domestic conference
    Poster presentation

  • 経口マグネシウム製剤投与によるシスプラチンの腎障害予防効果の検討
    田中 雄大, 山下 和彦, 土居 襟子, 西岡 達也, 久米 学, 槇本 博雄, Tachihara Motoko, Kobayashi Kazuyuki, 中村 任, Nishimura Yoshihiro, Hirai Midori
    医療薬学フォーラム2016, Jun. 2016, Japanese, 日本薬学会, 滋賀, Domestic conference
    Poster presentation

  • 局所進行期肺扁平上皮癌に対して放射線化学療法中に気管支食道瘻をきたし、頚部食道瘻造設により嘔気などの症状緩和に成功した一例
    國政 啓, 堂國 良太, 川口 亜記, 堀 朱矢, 田村 大介, Nakata Kyosuke, Tachihara Motoko, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第21回日本緩和医療学会学術大会, Jun. 2016, Japanese, 日本緩和医療学会, 京都, Domestic conference
    Poster presentation

  • EBUS-GSにてwithinが確認されたにもかかわらず診断がつかなかった症例の後方視的検討
    國政 啓, Tachihara Motoko, 羽間 大祐, 桐生 辰徳, 堂國 良太, 梅澤 佳乃子, 西村 春佳, 徳永 俊太郎, 堀 朱矢, 新家 治子, 櫨木 暢子, 田村 大介, Nakata Kyosuke, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第39回日本呼吸器内視鏡学会学術集会, Jun. 2016, Japanese, 日本呼吸器内視鏡学会, 名古屋, Domestic conference
    Oral presentation

  • Bronchoscopy using virtual navigation and EBUS-GS with or without fluoroscopy for peripheral lesions
    Tatsunori Kiriu, Tachihara Motoko, Daisuke Tamura, Daisuke Hazama, Ryota Dokuni, Kanoko Umezawa, Haruka Nishimura, Kei Kunimasa, Syuntaro Tokunaga, Suya Hori, Haruko Shinke, Nobuko Hazeki, Hiroshi Kamiryo, Kobayashi Kazuyuki, Nishimura Yoshihiro
    19th WCBIP/WCBE World Congress, May 2016, English, WCBIP/WCBE, Italy, Florence, International conference
    Oral presentation

  • 肺癌細胞株におけるアムルビシン耐性化機序の検討
    徳永 俊太郎, Nagano Tatsuya, 國政 啓, 田村 大介, Yamamoto Masatsugu, Tachihara Motoko, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第56回日本呼吸器学会学術講演会, Apr. 2016, Japanese, 日本呼吸器学会, 京都, Domestic conference
    Poster presentation

  • 腎移植後のタクロリムス内服中に反復する肺炎を来たし肺ノカルジア症と診断した1例
    川口 亜記, 徳永 俊太郎, 海老沢 馨, 田村 大介, Nakata Kyosuke, Nagano Tatsuya, Tachihara Motoko, Otera Hiroshi, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第113回日本内科学会講演会, Apr. 2016, Japanese, 日本内科学会, 東京, Domestic conference
    Poster presentation

  • EGFR-TKI耐性クローンに対する糖代謝阻害剤，癌幹細胞治療薬の有効性について
    國政 啓, Nagano Tatsuya, 徳永 俊太郎, 田村 大介, Tachihara Motoko, Kobayashi Kazuyuki, Nishimura Yoshihiro
    第56回日本呼吸器学会学術講演会, Apr. 2016, Japanese, 日本呼吸器学会, 京都, Domestic conference
    Poster presentation

  • プラチナ製剤既治療非小細胞肺癌に対するプラチナ製剤再投与の検討
    Tachihara Motoko, 徳永 由記久, 永野 達也, Otera Hiroshi, Kobayashi Kazuyuki, Funada Yasuhiro, Ohno Yoshiharu, Nishimura Yoshihiro
    Nov. 2014, Japanese, Domestic conference
    Oral presentation

  • Findings from the Hyogo “HAGAKI” project about children’s follow-up consultations after emergency department visits for asthma attacks
    Nobuko Hazeki, Funada Yasuhiro, Haruko Shinke, Suya Hori, Tamura Daisuke, Tachihara Motoko, Hiroshi Ohtera, Kobayashi Kazuyuki, Takashi Fukabori, Kyousuke Ishihara, Mizutaka Kajiyama, Akihito Ishida, Nishimura Yoshihiro
    第24回国際喘息学会日本・北アジア部会, Jul. 2014, Japanese, 名古屋, International conference
    Poster presentation

  • 気管支擦過細胞診にてアレルギー性気管支肺アスペルギルス症が疑われた1症例
    川口 智美, Tachihara Motoko, Kasai Daisuke, Tamura Daisuke, Uehara Keiichiro, Otera Hiroshi, Kobayashi Kazuyuki, Funada Yasuhiro, Sakai Yasuhiro, Nishimura Yoshihiro
    The 52th Annual Meeting of Japan Society of Clinical Cytology, Oct. 2013, Japanese, Japan Society of Clinical Cytology, 大阪, Domestic conference
    Poster presentation

  • Utility of cell blocks obtained by catheter aspiration via a guide sheath with Endobronchial Ultrasonography
    Nobuko Hazeki, Tachihara Motoko, Ryuko Tsukamoto, Yukihisa Hatakeyama, Yumiko Ishikawa, Haruko Shinke, Tamura Daisuke, Tatuya Nagano, Suya Hori, Sakashita Akihiro, Kasai Daisuke, Kobayashi Kazuyuki, Funada Yasuhiro, Kotani Yoshikazu, Sakai Yasuhiro, Tomoo Ito, Nishimura Yoshihiro
    18th International Congress of Cytology, May 2013, English, パリ, フランス, International conference
    Oral presentation

  • 癌関連網膜症を発症した肺小細胞癌の2例
    Kasai Daisuke, 日下部 祥人, 堀 朱矢, Tachihara Motoko, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro, 酒井 康余裕, Ohno Yoshiharu
    第98回肺癌学会近畿地方会, Feb. 2013, Japanese, The japan lung cancer society, 大阪, 【背景】 傍腫瘍性神経症候群(paraneoplastic neurological syndrome: PNS)は担癌患者に生じる、自己免疫学的機序によると考える神経障害である。PNSの頻度は約1％で、肺小細胞癌患者に頻度が高いとされている。PNSによる症状は多彩であるが、今回は肺小細胞癌に合併した癌関連網膜症の2例に関して報告する。【症例1】 80歳女性。左視力低下で発症し、その後右目の視力の低下もきたした。網膜電図で網膜全体に著しい電位の低下を認め癌関連網膜症が疑われ、全身精査にて肺癌と診断された。【症例2】 68歳男性。左視力低下で眼科を受診し、自己免疫性網膜炎を疑われて全身精査を行った結果肺小細胞癌と診断された。, Domestic conference
    Oral presentation

  • 癌関連網膜症を合併した肺小細胞肺癌の2例
    笠井 大助, 日下部 祥人, 堀 朱矢, Tachihara Motoko, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro, Sakai Yasuhiro, Ohno Yoshiharu
    第97回日本肺癌学会関西支部会, Feb. 2013, Japanese, The Japan Lung Cancer Society, 大阪, Domestic conference
    Oral presentation

  • 仮想気管支鏡ナビゲーション（Bf-NAVI）併用気管支鏡検査が有用であった症例の検討
    Tachihara Motoko, 畠山 由記久, 河 良崇, 石川 結美子, 新家 治子, Tamura Daisuke, 堀 朱矢, 櫨木 暢子, Kobayashi Kazuyuki, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro
    第5回肺機能イメージング研究会学術集会, Jan. 2013, Japanese, 肺機能イメージング研究会, 徳島, 【背景】肺末梢病変に対する仮想気管支鏡ナビゲーションシステム（Bf-NAVI, OLYMPUS）の有用性は知られてきている．またBf-NAVIは肺門・縦隔病変に対する穿刺ナビゲーションの機能も有している．今回，我々は，肺末梢病変の診断および中枢病変に対する経気管支診断において，Bf-NAVIが有用であった症例を経験したので報告する．【症例1】72歳, 男性．食道癌・喉頭癌の既往があり，歯肉癌の精査加療目的に入院中，右S1胸膜直下に9×7mm大の結節が認められ，気管支鏡検査を施行した．Bf-NAVIにて5次分岐まで確認し，生検施行，原発性肺腺癌と診断した．【症例2】49歳，女性．呼吸困難感を主訴に来院．胸部CTにて左肺動脈に接して28mm大の結節を認め，気管支鏡検査を施行した．可視範囲に腫瘍の表出はなく，X線透視下にて穿刺を行ったが，出血のみで確定診断, Domestic conference
    Oral presentation

  • 当院呼吸器内科での1年間の死亡症例26例の鎮静についての検討
    岩田 帆波, 柴田 裕美, 徳永 俊太郎, 川口 智美, 日下部 祥人, 石川 結美子, 新家 治子, Tachihara Motoko, Sakashita Akihiro, Kasai Daisuke, Kobayashi Kazuyuki, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro
    第80回 日本呼吸器学会畿地方会, Dec. 2012, Japanese, 呼吸器学会近畿地方会, 神戸, 2011年4月から2012年3月までの間に当院呼吸器内科入院中に死亡した26例の検討を行った。原疾患は悪性腫瘍が22件、間質性肺炎が4件であった。死因は原疾患の進行に伴うものが21例で、治療関連死と考えられるものが5例であった。3例でＮＰＰＶの使用が行われたが、喀血に対する気道確保目的で挿管された1例をのぞいては、挿管下での人工呼吸器管理は行われなかった。ミダゾラムの使用は11件。オピオイドの使用は21件。持続的深い鎮静を行った症例は6件であった。間質性肺炎の終末期についてもオピオイドや鎮静薬の使用を必要とする症例が多く、非癌呼吸器疾患についても苦痛緩和のための鎮静に関するガイドラインが必要と考えられた。, Domestic conference
    Oral presentation

  • 当院における仮想気管支内視鏡（BF-NAVI）の使用経験
    堀 朱矢, Tachihara Motoko, 畠山 由記久, 河 良崇, 石川 結美子, 新家 治子, Tamura Daisuke, 櫨木 暢子, Kobayashi Kazuyuki, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro
    第92回日本気管支内視鏡学会近畿支部会, Dec. 2012, Japanese, The Japan Society for respiratory bronchoscopy, 大阪, 【背景と目的】当院では2011年6月より，肺末梢病変に対し，仮想気管支内視鏡ソフトウェア（Bf-NAVI，オリンパスメディカルシステムズ）を併用して気管支内視鏡検査を施行している．今回，Bf-NAVIを用いて気管支鏡検査を施行した症例について，有効性の検討を行うとともに，その使用経験を報告する．【結果】病変は30病変で，病変の平均長径は21.4mm（8-42mm）であった． 21例で確定診断（肺癌19例，炎症性疾患2例）がつき，診断率は70%であった．細胞診は全症例で施行され，診断率は66％（20/30例）であった．組織診は25例で施行され，診断率は60％（15/25例）であった．また、30例中20例はガイドシース併用気管支腔内超音波断層法（EBUS-GS）を併用した．うち，EBUS-GSを併用し病変が描出できた症例は18症例であり，診断率は72％（, Domestic conference
    Oral presentation

  • 前立腺がんに対する抗アンドロゲン療法により発症した薬剤性間質性肺炎の1例
    辻前 正弘, 石川 結美子, Tachihara Motoko, 川口 智美, Tamura Daisuke, 櫨木 暢子, Kobayashi Kazuyuki, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro
    第80回 日本呼吸器学会畿地方会, Dec. 2012, Japanese, 呼吸器学会近畿地方会, 神戸, 前立腺がんに対する抗アンドロゲン療法により発症した薬剤性間質性肺炎の1例, Domestic conference
    Oral presentation

  • EGFRmutation陽性であった 肺大細胞神経内分泌癌の一例
    日下部 祥人, Kasai Daisuke, 徳永 俊太郎, 石川 結美子, Tachihara Motoko, Sakashita Akihiro, Kobayashi Kazuyuki, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro
    第80回日本呼吸器学会近畿地方会, Dec. 2012, Japanese, 日本呼吸器学会, 神戸, 症例は77歳、女性。近医で左下肺野腫瘤影を指摘され、2011年10月に当院紹介となる。初回の気管支鏡での細胞診にて小細胞癌の所見であったが、EGFRmutation陽性の所見も同時に得ていた。1 st lineとして、CBDCA＋VP‐16を4コース施行しPRであったが、2012年4月に骨転移病変出現を認め、原発巣も増大を認めた。気管支鏡検査にて再検した結果、組織診にて大細胞神経内分泌癌の診断に至った。, Domestic conference
    Oral presentation

  • ASVにより難治性高血圧症が改善した複合型睡眠時無呼吸症候群の一例
    櫨木 暢子, 堀 朱矢, 森本 茜, Kobayashi Kazuyuki, Sakashita Akihiro, Tachihara Motoko, Kasai Daisuke, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro
    第80回日本呼吸器学会近畿地方会 第110回日本結核病学会, Dec. 2012, Japanese, The Japanese Respiratory Society, 神戸, 睡眠時無呼吸症候群合併の難治性高血圧において、CPAP治療でも改善がみられない場合は複合型睡眠時無呼吸症候群の可能性を考え、タイトレーションの上、ASVデバイスも考慮する必要がある。, Domestic conference
    Oral presentation

  • 当科における傍腫瘍性神経症候群合併小細胞肺癌の臨床的検討
    Tachihara Motoko, 堀 朱矢, 畠山 由記久, Tamura Daisuke, 永野 達也, 櫨木 暢子, Kasai Daisuke, Funada Yasuhiro, Kotani Yoshikazu, Sakai Yasuhiro, Ohno Yoshiharu, Maniwa Yoshimasa, Nishimura Yoshihiro
    第53回日本肺癌学会総会, Nov. 2012, Japanese, The Japan Lung Cancer Society, 岡山, Domestic conference
    Poster presentation

  • Usefulness of the SD-101 for screening of Sleep Apnea Syndrome
    Nobuko Hazeki, Akane Morimoto, Kobayashi Kazuyuki, Yumiko Ishikawa, Suya Hori, Sakashita Akihiro, Tachihara Motoko, Kasai Daisuke, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro
    ERS ANNUAL CONGRESS 2013, Sep. 2012, English, Europian Respratory society, Vienna, RDI of SD-101 has very close correlation with AHI of PSG, however SD-101 may not detect hypopnea exactly in hypopnea predominant patients., International conference
    Public symposium

  • 大量喀血を来した肺移植後のリンパ脈管筋腫症の一例
    安田 絵里子, Kasai Daisuke, 日下部 祥人, 徳永 俊太郎, 石川 結美子, Tachihara Motoko, Sakashita Akihiro, Kobayashi Kazuyuki, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro
    第79回日本呼吸器学会近畿地方会, Jun. 2012, Japanese, The Japanese society internal medicine, 京都, 45歳女性。リンパ脈管筋腫症:LAMに対し片肺移植後、経過中に大量喀血。入院後、LAM肺側からの再喀血による気管支閉塞認め、片肺挿管、人工呼吸管理とした。その後気管支動脈塞栓術:BAE施行となった。, Domestic conference
    Oral presentation

  • 胸腺腫に対しCBDCA、PTX投与後に発症し、診断に苦慮したIsaacs症候群の一例
    日下部 祥人, Kasai Daisuke, 徳永 俊太郎, 石川 結美子, Tachihara Motoko, Sakashita Akihiro, Kobayashi Kazuyuki, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro
    第79回日本呼吸器学会近畿地方会, Jun. 2012, Japanese, 日本呼吸器学会, 京都, 症例は76歳、女性。胸腺腫治療のため、CBDCA＋PTXを2コース施行した後遷延する四肢の末梢院系障害症状に加え、膀胱直腸障害、疼痛症状の出現を認めていた。精査をおこなった結果胸腺腫に合併したIsaacs症候群と診断した。, Domestic conference
    Oral presentation

  • Screening of Sleep Disordered Breathing in patients with arrhythmias
    Nobuko Hazeki, Yumiko Ishikawa, Kobayashi Kazuyuki, Sakashita Akihiro, Tachihara Motoko, Kasai Daisuke, Funada Yasuhiro, Kotani Yoshikazu, Asumi Takei, Yoshida Akihiro, Hirata Ken-ichi, Nishimura Yoshihiro
    ATS 2013 Conference, May 2012, English, American Thoracic Society, San francisco, High prevalence of sleep apnea was detected in patients with arrhythmia. The patients with both arrhythmia and other heart disease had higher prevalence of SDB and were sever than with arrhythmia alone. Although EF of patients that had arrhythmia only kee, International conference
    Public symposium

  • Bf-NAVI併用によるTBNAにて確定診断しえた肺MALT Lymphomaの一症例
    Tamura Daisuke, Tachihara Motoko, 畠山 由紀久, 堀 朱矢, Kobayashi Kazuyuki, Funada Yasuhiro, Kotani Yoshikazu, 竹内 真衣, Sakai Yasuhiro, Nishimura Yoshihiro
    第35回日本呼吸器内視鏡学会学術集会, May 2012, Japanese, 日本呼吸器内視鏡学会, 東京, 症例は49才、女性。平成20年12月頃に呼吸困難感を自覚し近医受診。胸部造影CTにて左肺動脈内の血栓を疑われ、肺塞栓症の診断にて抗凝固療法を開始された。その後の経過中症状は消失し、経過観察されていたが平成22年1月に再度呼吸困難感が出現。再検査の結果左肺動脈内の血栓様陰影が残存していたため精査目的に当院当科紹介となる。各種画像やその他検査所見から肺血栓塞栓症は否定的と考え、左肺動脈に近接する腫瘍を疑ったため気管支鏡検査を施行するも病理学的に有意な所見を得られず。腫瘍は肺動脈に近接したB1+2c入口部背側の粘膜下付近に存在し、再検として盲目的なTBAC針による細胞採取の危険性を鑑み、仮想気管支ナビゲーションシステム（Bf-NAVI OLYMPUS）を用いて腫瘍の位置、TBAC針の穿刺部位を設定した上で再度気管支鏡によるアプローチを試み細胞を採取、確定診, Domestic conference
    Poster presentation

■ Research Themes
  • 永野 達也
    学術研究助成基金助成金／基盤研究(C), Apr. 2017 - Mar. 2020
    Competitive research funding

  • 立原 素子
    学術研究助成基金助成金／基盤研究(C), Apr. 2013 - Mar. 2016, Principal investigator
    Competitive research funding

  • （AMED）高齢者進行非扁平上皮非小細胞肺癌に対する標準的化学療法の確立に関する研究/JCOG1210/WJOG7813L『高齢者進行非扁平上皮非小細胞肺癌に対するドセタキセル単剤療I
    立原 素子
    革新的がん医療実用化研究事業, 2016, Principal investigator
    Competitive research funding

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