SEARCH
Search Details
TANIMURA KenjiGraduate School of Medicine / Faculty of Medical SciencesProfessor
Researcher basic information
■ Research news- 27 Jan. 2021, Fetal and neonatal therapies improve prognosis of congenital cytomegalovirus infection
- 21 Jul. 2020, Discovery of novel autoantibody that is a major risk factor for recurrent pregnancy loss
- 21 Jul. 2017, Issues with maternal screening for congenital cytomegalovirus infection
- 25 Nov. 2016, New method for predicting congenital CMV infection during the prenatal period
Research activity information
■ Award- Apr. 2021 第12回ロート女性健康科学研究賞, HLA クラスⅡ分子の新しい抗原提示機能を応用した不育症・ 産 科異常症の病態解明ならびに治療法開発を目指した基礎ならびに臨床研究』、ロート製薬株式会社
- Oct. 2017 神戸大学医学部, 平成28年度神戸大学医学部優秀学術論文賞, Prediction of congenital cytomegalovirus infection in high-risk pregnant womenOthers
- Jul. 2017 兵庫県産科婦人科学会, 平成29年度兵庫県産科婦人科学会賞, Prediction of congenital cytomegalovirus infection in high-risk pregnant womenJapan society
- Oct. 2016 International Workshop on Autoantibodies and Autoimmunity, Award for Exceptional Abstract and Presentation, beta2-glycoprotein I / HLA class II complexes are novel autoantigens in antiphospholipid syndromeInternational society
- Nov. 2015 日本生殖免疫学会, 第30回日本生殖免疫学会賞, β2グリコプロテインI/MHCクラスII複合体が抗リン脂質抗体症候群の病態に関連するJapan society
- Jan. 2014 大阪大学微生物病研究所, 平成25年度大阪大学微生物病研究所業績発表会 優秀学術賞, Cellular misfolded proteins transported to the cell surface by MHC class II molecules are targets for autoantibodies in autoimmune diseasesOthers
- Congenital Toxoplasma gondii (T. gondii) infection, which can be caused by a primary T. gondii infection during pregnancy, results in severe neurological sequelae in affected children. We have been conducting a prospective cohort study since January 2019 on pregnant women who were suspected of having primary T. gondii infection based on serological tests. In this study, congenital infection was diagnosed using semi-nested polymerase chain reaction (PCR) to detect the B1 gene in the body fluids of newborns. Up until December 2023, forty-one newborns born to mothers suspected of having primary T. gondii infection during pregnancy underwent B1 gene semi-nested PCR tests and anti-T. gondii immunoglobulin (Ig) G and IgM measurements of their blood samples. Eight newborns showed no clinical symptoms of congenital T. gondii infection; however, they were diagnosed with congenital T. gondii infection according to positive PCR results. However, none of the eight infants eventually exhibited any sign of congenital infection, as their serum samples tested negative for anti-T. gondii IgM and IgG until 12 months of age. Therefore, clinicians should consider discrepancies in the diagnosis of congenital T. gondii infection between PCR tests using body fluids of newborns and serological tests during their infantile period.Mar. 2025, Microorganisms, 13(3) (3), English, International magazineScientific journal
- Mar. 2025, Microorganisms, 13(3) (3)Scientific journal
- Protein induced by vitamin K absence or antagonist-II (PIVKA-II) is avitamin K (VK) deficiency indicator in neonates. However, PIVKA-II detection frequency in neonatal blood at birth and the correlation between PIVKA-II and gestational age are unclear. We retrospectively analyzed infants admitted to our institution between June 1, 2018, and March 31, 2022, whose clinical and PIVKA-II data were available, and classified them into preterm and term infant groups. Overall incidence of PIVKA-II-positive cases (≥ 50 mAU/mL) was 42.8%, including 0.6% apparent VK deficiency (≥ 5000 mAU/mL), 3.1% experimental VK deficiency (1000-4999 mAU/mL), and 10.7% latent VK deficiency (200-999 mAU/mL) cases. Incidence of PIVKA-II-positive cases was significantly higher in the term group than in the preterm group (49.4% vs. 29.7%, p < 0.001). Gestational age correlated with PIVKA-II levels (r2 = 0.117, p < 0.0001). Median serum PIVKA-II levels and incidence of PIVKA-II-positive cases (≥ 50 mAU/mL, 16.4%) were lower at 5 days after birth than at birth, possibly reflecting the postnatal VK prophylaxis impact. Only one infant was diagnosed with VK deficiency bleeding (PIVKA-II levels, at birth: 10,567 mAU/mL; at day 5: 2418 mAU/mL). Thus, serum PIVKA-II levels after birth weakly correlated with gestational age. VK deficiency was more common in term infants than in preterm infants.Jan. 2024, Scientific reports, 14(1) (1), 921 - 921, English, International magazineScientific journal
- INTRODUCTION: Anti-β2-glycoprotein I (β2GPI)/human leukocyte antigen (HLA)-DR antibodies may be a risk factor for recurrent pregnancy loss (RPL). The therapeutic modality for women with RPL and anti-β2GPI/HLA-DR antibody positivity has not been evaluated. This prospective, multicenter, observational study aimed to assess whether low-dose aspirin (LDA) and/or heparin therapies improve pregnancy outcomes in women with RPL who tested positive for anti-β2GPI/HLA-DR antibodies. METHODS: Between August 2019 and December 2021, 462 women with RPL underwent anti-β2GPI/HLA-DR antibody measurements and risk assessments for RPL. Each attending physician decided the treatment modality for women with RPL who tested positive for anti-β2GPI/HLA-DR antibodies, and their pregnancy outcomes were followed up until December 2023. Finally, 47 pregnancies in 47 women with RPL and anti-β2GPI/HLA-DR antibody positivity were included in the analysis and were divided into two groups regarding whether they were treated with LDA and/or unfractionated heparin (UFH) (LDA/UFH group, n = 39) or with neither of them (non-LDA/non-UFH group, n = 8). The rates of live birth and pregnancy complications (i.e., preeclampsia and preterm delivery before 34 gestational weeks due to placental insufficiency) were compared between the two groups. RESULTS: The live birth rate in the LDA/UFH group was higher than that in the non-LDA/non-UFH group (87.2% vs 50.0%, p = 0.03). The pregnancy complication rate in the LDA/UFH group was significantly lower than that in the non-LDA/non-UFH group (5.9% vs 50.0%, p = 0.048). Among 21 women who tested positive for anti-β2GPI/HLA-DR antibodies and had no other risk factors for RPL, the live birth rate in the LDA/UFH group (n = 14) was much higher than that in the non-LDA/non-UFH group (n = 7) (92.9% vs 42.9%, p = 0.03). DISCUSSION: This study, for the first time, demonstrated that LDA and/or UFH therapies are effective in improving pregnancy outcomes in women with RPL and aβ2GPI/HLA-DR antibody positivity.2024, Frontiers in immunology, 15, 1445852 - 1445852, English, International magazineScientific journal
- Dec. 2023, Arthritis Research and Therapy, 25(1) (1)Scientific journal
- BACKGROUND: β2-glycoprotein I (β2GPI) complexed with human leukocyte antigen DR (β2GPI/HLA-DR) was found to be a major autoantibody target in antiphospholipid syndrome (APS). This study aimed to reveal the association between anti-β2GPI/HLA-DR antibodies and vascular thromboses in women with systemic rheumatic diseases. METHODS: We conducted a retrospective longitudinal study. We measured anti-β2GPI/HLA-DR antibodies and compared them with anti-phospholipid antibody (aPL) profiles and the adjusted global antiphospholipid syndrome score (aGAPSS). Using receiver operating characteristic (ROC) analysis, we determined the best cut-off value for arterial thrombosis. We also evaluated the validity of anti-β2GPI/HLA-DR antibodies by adding to conventional cardiovascular risk factors in multivariate logistic analysis. RESULTS: We evaluated 704 patients, including 66 (obstetric or thrombotic) APS, 13 primary APS, and 78 asymptomatic aPL carriers. Seventy-seven patients had a history of arterial thrombosis, and 14 patients had both arterial and venous thrombosis. These 14 patients, as well as patients with aGAPSS > 10 or triple-positive aPL profiles, displayed high anti-β2GPI/HLA-DR antibody titers. The ROC curve showed a sensitivity, specificity, and area under the curve (AUC) for arterial thrombosis of 33.8%, 91.4%, and 0.6009, respectively, with a cut-off value of 172.359 U/mL. The anti-β2GPI/HLA-DR antibody positivity using this cut-off value yielded an odds ratio of 5.13 (95%CI: 2.85-9.24), significantly improving the AUC from 0.677 to 0.730. CONCLUSION: Anti-β2GPI/HLA-DR antibodies are associated with arterial thrombosis in female patients with systemic rheumatic diseases.Oct. 2023, Arthritis research & therapy, 25(1) (1), 195 - 195, English, International magazineScientific journal
- Aug. 2023, Journal of Reproductive Immunology, 158Scientific journal
- To evaluate whether anti-β2-Glycoprotein I/HLA-DR (anti-β2GPI/HLA-DR) antibody is associated with pathophysiology of infertility, 224 women with infertility were enrolled from July 2020 to December 2021 in this prospective study. The serum levels of anti-β2GPI/HLA-DR antibody (normal < 73.3 U) were determined in 224 women with infertility. Backgrounds, causes and clinical factors were compared between women with and without anti-β2GPI/HLA-DR antibody. Forty (17.9 %) of the 224 women tested positive for anti-β2GPI/HLA-DR antibody. The prevalence of endometriosis was higher in women with anti-β2GPI/HLA-DR antibody than in women without the antibody (32.5 %, 13/40 vs. 17.4 %, 32/184; P = 0.048). Logistic regression analyses revealed that, among clinical factors and diseases, endometriosis was associated with anti-β2GPI/HLA-DR antibody positivity in infertile women (adjusted-odds ratio [OR] 3.01, 95 % confidence interval [CI] 1.30-6.99; P = 0.010). Twenty-three (15.5 %) of 148 women who underwent assisted reproductive technology (ART) tested positive for anti-β2GPI/HLA-DR antibody. The prevalence of recurrent implantation failure (RIF) defined as three or more implantation failures following in vitro fertilization and embryo transfers was higher in women with ART who tested positive for the antibody (43.5 %, 10/23) than in women with ART who tested negative (20.8 %, 26/125; P = 0.032). Logistic regression analyses revealed that RIF was associated with anti-β2GPI/HLA-DR antibody positivity in women with ART (adjusted-OR 2.92, 95 % CI 1.05-8.11; P = 0.040). Anti-β2GPI/HLA-DR antibody may be associated with the pathophysiology of infertility, endometriosis and RIF; and can be a potential therapeutic target in infertility.Aug. 2023, Journal of reproductive immunology, 158, 103955 - 103955, English, International magazineScientific journal
- Jul. 2023, International Journal of Molecular Sciences, 24(13) (13)Scientific journal
- 日本産婦人科・新生児血液学会, Mar. 2023, 日本産婦人科・新生児血液学会誌, 32(2) (2), 27 - 33, Japanese
- Congenital cytomegalovirus infection (cCMV) can cause fetal growth restriction (FGR) and severe sequelae in affected infants. Clinicians generally suspect cCMV based on multiple ultrasound (US) findings associated with cCMV. However, no studies have assessed the diagnostic accuracy of fetal US for cCMV-associated abnormalities in FGR. Eight FGR and 10 non-FGR fetuses prenatally diagnosed with cCMV were examined by undergoing periodic detailed US examinations, as well as postnatal physical and imaging examinations. The diagnostic accuracy of prenatal US for cCMV-associated abnormalities was compared between FGR and non-FGR fetuses with cCMV. The diagnostic sensitivity rates of fetal US for cCMV-related abnormalities in FGR vs. non-FGR fetuses were as follows: ventriculomegaly, 66.7% vs. 88.9%; intracranial calcification, 20.0% vs. 20.0%; cysts and pseudocysts in the brain, 0% vs. 0%; ascites, 100.0% vs. 100.0%; hepatomegaly, 40.0% vs. 100.0%; splenomegaly, 0% vs. 0%. The diagnostic sensitivity of fetal US for hepatomegaly and ventriculomegaly in FGR fetuses with cCMV was lower than that in non-FGR fetuses with cCMV. The prevalence of severe long-term sequelae (e.g., bilateral hearing impairment, epilepsy, cerebral palsy, and severe developmental delay) in the CMV-infected fetuses with FGR was higher, albeit non-significantly. Clinicians should keep in mind the possibility of overlooking the symptoms of cCMV in assessing fetuses with FGR.Jan. 2023, Diagnostics (Basel, Switzerland), 13(2) (2), English, International magazineScientific journal
- Intramural pregnancy is a rare form of ectopic pregnancy. It is defined by a gestation within the uterine wall, completely surrounded by myometrium and separated from the uterine cavity and the fallopian tube. We report a rare case of intramural ectopic pregnancy. If a patient has a history of intrauterine surgery or myomectomy, the possibility of intramural pregnancy, although rare, should not be ruled out.Jan. 2023, Asian journal of endoscopic surgery, English, Domestic magazine
- BACKGROUND: Free bilirubin (Bf) is a better marker than total serum bilirubin (TSB) for predicting bilirubin encephalopathy (BE). To date, two UGT1A1 genetic variants (rs4148323 and rs3064744) have been associated with neonatal hyperbilirubinemia; however, the direct association between UGT1A1 variants and Bf levels in newborns has not been elucidated. METHODS: We retrospectively analyzed the clinical data of 484 infants, including the genotype data of two UGT1A1 genetic variants. We divided the infants into a high Bf group (Bf ≥ 1.0 µg/dL, n = 77) and a non-high Bf group (Bf < 1.0 µg/dL, n = 407), based on the peak Bf values. Logistic regression analysis was performed to calculate the odds ratios (ORs) for each variant allele compared to wild-type alleles. RESULTS: The frequencies of the A allele in rs4148323 and (TA)7 allele in rs3064744 in the high Bf group (29% and 4%, respectively) were significantly different from those in the non-high Bf group (16% and 12%, respectively). In logistic regression analysis, for rs4148323, the A allele was significantly associated with an increased risk of hyper-free bilirubinemia over the G allele (adjusted OR: 1.80, 95% confidence interval [CI]: 1.19-2.72, p < 0.01). However, for rs3064744, the (TA)7 allele was significantly associated with a decreased risk of hyper-free bilirubinemia over the (TA)6 allele (adjusted OR: 0.42, 95% CI: 0.18-0.95, p = 0.04). CONCLUSIONS: This study is the first to show that the A allele in rs4148323 is a risk factor and that the (TA)7 allele in rs3064744 is a protective factor for developing hyper-free bilirubinemia in Japanese newborns.Oct. 2022, International journal of environmental research and public health, 19(20) (20), English, International magazineScientific journal
- (株)日本医事新報社, Sep. 2022, 日本医事新報, (5133) (5133), 51 - 51, Japanese
- 日本女性栄養・代謝学会, May 2022, 日本女性栄養・代謝学会誌, 27(2) (2), 131 - 131, Japanese
- INTRODUCTION: The aims were to investigate the clinical characteristics of Toxoplasma gondii (T. gondii) immunoglobulin (Ig) M-positive mothers and to clarify the incidences of serum T. gondii IgM or blood T. gondii DNA positivity in newborns born to the mothers and the actual congenital T. gondii infection. METHODS: Mothers with T. gondii IgM positivity and newborns born to the mothers from 2013 to 2020 were prospectively investigated. Serum T. gondii IgG and IgM were measured by enzyme-linked immunosorbent assay. Blood T. gondii DNA was detected by semi-nested polymerase chain reaction. Congenital T. gondii infection was diagnosed based on clinical characteristic manifestations with serum T. gondii IgG positivity at any age or T. gondii IgG positivity after 12 months of age. RESULTS: Among 71 T. gondii IgM-positive mothers, including one with triplets, 41% had low T. gondii IgG avidity index and 73% received maternal therapy. Among 73 newborns who were examined for serum T. gondii IgG and IgM at birth, none had clinical manifestations, and one (1.4%) had T. gondii IgM positivity. Among 32 newborns who were examined for blood T. gondii DNA at birth, two (6.3%) were positive. All patients with serum T. gondii IgM or blood T. gondii DNA positivity showed T. gondii IgG negativity within 12 months of age. CONCLUSIONS: A few newborns born to T. gondii IgM-positive mothers were suspected of having congenital T. gondii infection based on serum T. gondii IgM or blood T. gondii DNA testing at birth. However, none developed congenital T. gondii infection.Apr. 2022, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 28(4) (4), 486 - 491, English, International magazineScientific journal
- AIM: The aim of this prospective cohort study was to evaluate the risk factors for postpartum glucose intolerance (GI) in women with gestational diabetes mellitus (GDM). METHOD: A total of 140 women with GDM were enrolled. Of these, 115 underwent a 75-g oral glucose tolerance test (OGTT) at 12 weeks after delivery. Clinical factors and parameters in the antepartum 75-g OGTT associated with postpartum GI were evaluated by logistic regression analyses. RESULTS: Twenty-two (19.1%) of the 115 women with GDM developed postpartum GI. The univariate and multivariable logistic regression analyses revealed that low oral disposition index (DI) was a risk factor for postpartum GI (OR, 0.2; 95% CI, 0.04-0.7; p < 0.05), and that no clinical factors were associated with postpartum GI. CONCLUSIONS: Lower oral DI on the antepartum 75-g OGTT may be a useful marker for identifying GDM women who are at high risk for postpartum GI.Jan. 2022, The journal of obstetrics and gynaecology research, English, International magazineScientific journal
- Congenital cytomegalovirus (CMV) infection may cause severe long-term sequelae. Recent studies have demonstrated that early antiviral therapy for infants with symptomatic congenital CMV (cCMV) infection may improve neurological outcomes; thus, accurate identification of newborns at high risk of cCMV infection may contribute to improved outcomes in affected children. However, maternal serological screening for cCMV infection by diagnosing primary infection during pregnancy, which is a popular screening strategy, is inefficient, because the number of cCMV infections with nonprimary causes, including reactivation of or reinfection with CMV, is larger than that of cCMV infections with primary causes. Low levels of neutralizing antibodies against pentameric complex and potent CMV-specific T cell-mediated immune responses are associated with an increased risk of cCMV infection. Conversely, our prospective cohort studies revealed that the presence of maternal fever/flu-like symptoms, threatened miscarriage/premature delivery, or actual premature delivery are risk factors for cCMV infection among both women with normal pregnancies and those with high-risk ones, regardless of whether the infection is primary or nonprimary. This review focused on host immune responses to human CMV and current knowledge of potential biological and clinical factors that are predictive of cCMV infection.Dec. 2021, International journal of molecular sciences, 22(24) (24), English, International magazineScientific journal
- For symptomatic congenital cytomegalovirus infections (CCMVI), the usefulness of changes in viral load during valganciclovir (VGCV) treatment for the prediction of hearing dysfunction (HD) is unclear. To determine the utility of viral load change in the whole blood or urine for the prediction of HD, we performed a retrospective study to compare viral load changes during VGCV treatment between CCMVI infants with (n = 12) or without (n = 8) HD at six months of corrected age, whose blood and urine viral loads were measured continuously for eight weeks from April 2009 to December 2019. There was no significant difference in the changes in both the blood and urine viral loads after the initiation of VGCV treatment between CCMVI infants between the groups. Moreover, this negative result was maintained in the analysis for each six weeks or six months treatment period. In conclusion, the change in viral load during antiviral therapy is not useful for the prediction of HD at six months of corrected age in symptomatic CCMVI.Dec. 2021, Journal of clinical medicine, 10(24) (24), English, International magazineScientific journal
- Placental mesenchymal dysplasia (PMD) is a rare placental abnormality that is closely related to severe pregnancy complications. A 27-year-old woman with fetal growth restriction and placenta previa was referred to a university hospital at 22 gestational weeks (GW). She was suspected of having a twin pregnancy with a complete or partial hydatidiform mole and coexisting normal live fetus, because two separate placentas, an enlarged one with multiple cystic lesions and a normal one, were shown on ultrasound examinations. At 27 GW, she experienced a sudden intrauterine fetal death (IUFD) after bleeding due to placenta previa, despite confirmation of fetal well-being at 2 h before bleeding. After delivery, histopathological examination confirmed the diagnosis of PMD. This is the first documented case of a woman with PMD and placenta previa who had a sudden IUFD after bleeding. Patients with both PMD and placenta previa should be considered at extremely high risk for IUFD.Nov. 2021, The journal of obstetrics and gynaecology research, 47(11) (11), 4087 - 4092, English, International magazine[Refereed]
- Severe small-for-gestational-age (sSGA) infants exhibit increased mortality and morbidity. Oxidative stress is suggested to be involved in intrauterine growth restriction. This retrospective study aimed to evaluate the oxidative stress level at birth in an sSGA population. Sera of 28 sSGA (sSGA group) and 31 non-sSGA (control group) infants, born at our hospital between March 2017 and March 2020, were evaluated. Oxidative stress (derivative of reactive oxidative metabolites: d-ROM level), biological antioxidant potential (BAP) level, and the ratio of d-ROM/BAP level (oxidative stress index: OSI) were measured. The sSGA group had a significantly lower birth weight (BW), BW z-score, head circumference, and height than the control group (all p < 0.05). No significant difference was noted in the BAP level; sSGA infants exhibited a significantly higher d-ROM level than control infants. sSGA infants showed a significantly increased OSI compared with control infants, and the BW z-score was inversely correlated with d-ROM levels and OSI in sSGA infants (R2 = 0.300; p < 0.01 and R2 = 0.319; p = 0.02, respectively) but not in controls. In conclusion, sSGA infants, including preterm infants, exhibited higher oxidative stress at birth. The severity of fetal growth restriction was significantly correlated with oxidative stress levels at birth in sSGA infants.Oct. 2021, International journal of environmental research and public health, 18(20) (20), English, International magazine[Refereed]Scientific journal
- A 40-year-old primigravida woman with a monochorionic-triamniotic (MT) triplet pregnancy was hospitalized due to threatened abortion at 16 gestational weeks. Polyhydramnios in two fetuses and oligohydramnios in the third supported a diagnosis of feto-fetal transfusion syndrome (FFTS) at 23 weeks and 3 days of gestation. Severe dyspnea and liver dysfunction required intensive care unit admission and mechanical ventilation support, and abdominal compartment syndrome (ACS) caused by polyhydramnios was clinically diagnosed. When her general condition was not improved regardless of intensive care, the patient delivered the three fetuses by cesarean section at 23 weeks and 5 days gestation. Abdominal decompression was achieved with delivery, and the patient was discharged 13 days after operation without morbidity. This is the first case report of ACS caused by FFTS in a MT triplet pregnancy resulting in extremely preterm birth.Corresponding, Sep. 2021, The journal of obstetrics and gynaecology research, 47(9) (9), 3370 - 3373, English, International magazine[Refereed]
- INTRODUCTION: Placenta accreta spectrum (PAS) is a life-threating obstetric complication, and prenatal prediction of PAS can decrease maternal morbidity and mortality. The aim of this prospective cohort study was to determine the clinical factors associated with PAS. METHODS: Pregnant women who delivered at a university hospital were enrolled. Clinical data were collected from medical records, and logistic regression analyses were performed to determine which clinical factors were associated with PAS. RESULTS: Eighty-seven (2.1%) of the 4146 pregnant women experienced PAS. Multivariable analyses revealed that a prior history of cesarean section (CS) (OR 3.3; 95% CI 1.9-5.7; p < 0.01), dilation and curettage (D&C) (OR 2.8; 95% CI 1.7-4.6; p < 0.01), hysteroscopic surgery (OR 5.7; 95% CI 2.3-14.4; p < 0.01), uterine artery embolization (UAE) (OR 44.1; 95% CI 13.8-141.0; p < 0.01), current pregnancy via assisted reproductive technology (ART) (OR 4.1; 95% CI 2.4-7.1; p < 0.01), and the presence of placenta previa in the current pregnancy (OR 13.1; 95% CI 7.9-21.8; p < 0.01) were independently associated with the occurrence of PAS. CONCLUSION: Pregnant women who have a prior history of CS, D&C, hysteroscopic surgery, UAE, current pregnancy via ART, and the presence of placenta previa in the current pregnancy are high risk for PAS.Corresponding, Sep. 2021, Placenta, 112, 180 - 184, English, International magazine[Refereed]Scientific journal
- PURPOSE: To evaluate the efficacy of superselective transcatheter arterial embolization (TAE) for intractable postpartum hemorrhage (PPH) due to genital tract trauma (GTT) after vaginal delivery. METHODS: We evaluated 27 patients who underwent TAE for intractable PPH due to GTT after vaginal delivery at our institution between January 2008 and December 2020. Patients were divided into two groups according to TAE procedure; TAE performed as close as possible to the bleeding point, at least more peripherally than the second branch of the anterior division of the internal iliac artery, was defined as superselective TAE (S-TAE). TAE performed from the proximal segment of the internal iliac artery was defined as proximal TAE (P-TAE). Patient characteristics, pre-procedural contrast-enhanced computed tomography (CE-CT), procedure details, technical/clinical success, and complications were evaluated separately for the S-TAE and P-TAE groups. RESULTS: The combined technical/clinical success rate was 92%. No major procedure-related complications were seen (mean follow-up: 6.12 ± 3.93 days). The combined technical/clinical success rate of S-TAE was 100% and of P-TAE was 67% (p = 0.04). S-TAE was performed more frequently in patients with pre-procedural CE-CT (p = 0.01) and use of permanent embolic materials (p = 0.003). CONCLUSION: S-TAE is safe and effective for intractable PPH due to GTT. Pre-procedural CE-CT may be useful for detecting the culprit artery and be helpful in performing S-TAE.Jul. 2021, Emergency radiology, 28(6) (6), 1127 - 1133, English, International magazine[Refereed]Scientific journal
- The incidence of syphilis infection among pregnant women is persistently high in Japan and in several developed countries. Here, we report the utility of intravenous benzylpenicillin in 13 infants born to mothers with syphilis infection. Because the recommended treatment (intramuscular benzathine benzylpenicillin) is not available in Japan, we intravenously administered benzylpenicillin for 10 days, which is used for treatment in high-risk cases. The administration of benzylpenicillin in low-risk infants resulted in an extended duration of parent-to-infant separation and increased the infants' exposure to invasive procedures. Thus, establishing evidence of the adequacy of no-treatment follow-up in low-risk groups and introducing intramuscular injections of benzathine benzylpenicillin may improve the management of infants suspected with congenital syphilis in Japan.Jul. 2021, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 27(11) (11), 1662 - 1664, English, International magazine[Refereed]Scientific journal
- We have found that a novel autoantibody against β2-glycoprotein I (β2GPI)/human leukocyte antigen (HLA) class II complexes (anti-β2GPI/HLA-DR) is involved in the pathogenesis of antiphospholipid syndrome (APS). It was also found that many APS patients who were negative for conventional antiphospholipid antibodies (aPLs) possessed anti-β2GPI/HLA-DR. These results suggested that anti-β2GPI/HLA-DR measurements may be more sensitive for diagnosing APS than conventional aPLs tests. Recurrent pregnancy loss (RPL) is one of the clinical manifestations of APS. Therefore, a prospective, multicenter, cross-sectional study were conducted to assess whether anti-β2GPI/HLA-DR is also associated with RPL. This study of 227 couples with RPL revealed that 22.9% (52/227) of RPL women tested positive for anti-β2GPI/HLA-DR, and 24 (19.8%) of the 121 couples with unexplained RPL tested positive for anti-β2GPI/HLA-DR. Interestingly, thirty-five of the 52 (67.3%) RPL patients who were positive for anti-β2GPI/HLA-DR possessed no conventional aPLs of criteria. This novel autoantibody against β2GPI/HLA class II complexes may be a major risk factor for RPL, and it may be a promising biomarker for diagnosing APS.Lead, IntechOpen, Apr. 2021, Antiphospholipid Syndrome - Recent Advances in Basic and Clinical Aspects [Working Title][Refereed][Invited]In book
- Heme oxygenase (HO) is the rate-limiting enzyme in the heme catabolic pathway, which degrades heme into equimolar amounts of carbon monoxide, free iron, and biliverdin. Its inducible isoform, HO-1, has multiple protective functions, including immune modulation and pregnancy maintenance, showing dynamic alteration during perinatal periods. As its contribution to the development of perinatal complications is speculated, two functional polymorphisms of the HMOX1 gene, (GT)n repeat polymorphism (rs3074372) and A(-413)T single nucleotide polymorphism (SNP) (rs2071746), were studied for their association with perinatal diseases. We systematically reviewed published evidence on HMOX1 polymorphisms in perinatal diseases and clarified their possible significant contribution to neonatal jaundice development, presumably due to their direct effect of inducing HO enzymatic activity in the bilirubin-producing pathway. However, the role of these polymorphisms seems limited for other perinatal complications such as bronchopulmonary dysplasia. We speculate that this is because the antioxidant or anti-inflammatory effect is not directly mediated by HO but by its byproducts, resulting in a milder effect. For better understanding, subtyping each morbidity by the level of exposure to causative environmental factors, simultaneous analysis of both polymorphisms, and the unified definition of short and long alleles in (GT)n repeats based on transcriptional capacity should be further investigated.Mar. 2021, International journal of environmental research and public health, 18(7) (7), English, International magazine[Refereed]Scientific journal
- Fetal Goitrous Hyperthyroidism in a Pregnant Woman with Triiodothyronine-Predominant Graves' Disease.Triiodothyronine (T3)-predominant Graves' disease is characterized by increased serum free T3 (FT3) levels after free thyroxine (FT4) levels become normal or even low during antithyroid drug treatment. We encountered a 34-year-old pregnant woman, gravida 5 para 4, who was complicated by T3-predominant Graves' disease. She was diagnosed with Graves' disease at 20 years old, and had received methimazole. Methimazole was changed to potassium iodide to reduce the risk of congenital anomalies during the first trimester. The dose of antithyroid drugs was adjusted based on maternal FT4 levels, so that maternal Graves' disease deteriorated and fetal goitrous hyperthyroidism appeared during the second trimester. Since the fetus presented goiter and tachycardia at 27-28 gestational weeks, doses of methimazole and potassium iodide were increased. A male newborn weighing 2604 g was delivered by a cesarean section at 35 gestational weeks. The newborn was diagnosed with neonatal hyperthyroidism, and received methimazole for six months. He developed normally with normal thyroid function at 1 year old. In pregnancies complicated by T3-predominant Graves' disease, the kinds and doses of antithyroid drugs have to be carefully selected to maintain maternal levels of FT4 as well as FT3 within the normal range, considering trimesters of pregnancy, teratogenicity of medication, and maternal levels of thyroid-stimulating hormone receptor antibody.Feb. 2021, The Kobe journal of medical sciences, 66(4) (4), E153-E158, English, Domestic magazine[Refereed]Scientific journal
- To date, the difference in neurodevelopmental outcomes between late preterm infants (LPI) born at 34 and 35 gestational weeks (LPI-34 and LPI-35, respectively) has not been elucidated. This retrospective study aimed to evaluate neurodevelopmental outcomes at 18 months of corrected age for LPI-34 and LPI-35, and to elucidate factors predicting neurodevelopmental impairment (NDI). Records of all LPI-34 (n = 93) and LPI-35 (n = 121) admitted to our facility from 2013 to 2017 were reviewed. Patients with congenital or chromosomal anomalies, severe neonatal asphyxia, and without developmental quotient (DQ) data were excluded. Psychomotor development was assessed as a DQ using the Kyoto Scale of Psychological Development at 18 months of corrected age. NDI was defined as DQ <80 or when severe neurodevelopmental problems made neurodevelopmental assessment impossible. We compared the clinical characteristics and DQ values between LPI-34 (n = 62) and LPI-35 (n = 73). To elucidate the factors predicting NDI at 18 months of corrected age, we compared clinical factors between the NDI (n = 17) and non-NDI (n = 118) groups. No significant difference was observed in DQ values at 18 months of corrected age between the groups in each area and overall. Among clinical factors, male sex, intraventricular hemorrhage (IVH), hyperbilirubinemia, and severe hyperbilirubinemia had a higher prevalence in the NDI group than in the non-NDI group, and IVH and/or severe hyperbilirubinemia showed the highest Youden Index values for predicting NDI. Based on the results of this study, we can conclude that no significant difference in neurodevelopmental outcomes at 18 months of corrected age was observed between LPI-34 and LPI-35. Patients with severe hyperbilirubinemia and/or IVH should be considered to be at high risk for developing NDI.Jan. 2021, International journal of environmental research and public health, 18(2) (2), English, International magazine[Refereed]Scientific journal
- This study aimed to investigate the long-term changes in awareness of and knowledge about mother-to-child infections across 6 years in Japan. A questionnaire survey was conducted at our facility from October 2012 to January 2018, and the study periods were divided into 4 phases comprising 16 months each. A multiple-choice questionnaire assessed participants' awareness of the following 13 pathogens of mother-to-child infections: cytomegalovirus (CMV), Toxoplasma gondii (T. gondii), hepatitis B virus, rubella virus, herpes simplex virus, parvovirus B19, hepatitis C virus, human immunodeficiency virus, human T cell leukemia virus type-1, measles virus, varicella-zoster virus, Chlamydia trachomatis, and Treponema pallidum. For the selected four pathogens (i.e., CMV, rubella virus, T. gondii, and parvovirus B19), the questionnaire also evaluated participants' knowledge of transmission routes, the most susceptible time of infection that could yield severe fetal disease during pregnancy, the maximum frequency of fetal infection in cases of maternal infection, and methods to prevent maternal infection. In total, 1433 pregnant Japanese women were included in this study. There was no secular change in awareness of the pathogens concerning mother-to-child infections over time, and we also clarified that the detailed knowledge of the four pathogens of typical mother-to-child infections did not improve. Since knowledge about methods to prevent maternal infection is still insufficient for all pathogens, further advocacy is required to prevent mother-to-child infections.2021, PloS one, 16(1) (1), e0244945, English, International magazine[Refereed]Scientific journal
- Infants with symptomatic congenital cytomegalovirus infection (cCMV) suffer from long-term sequelae. This study aimed at evaluating the efficacy of combining immunoglobulin (Ig) fetal therapy (FT) and neonatal therapy (NT) with antiviral drugs to improve neurological outcomes of affected infants. Women whose fetuses had symptomatic cCMV received Ig injection into the fetal peritoneal cavity and/or maternal blood as FT, while affected newborns received oral valganciclovir or intravenous ganciclovir as NT. We compared the neurological outcomes at ≥18 months old between infants receiving FT with or without NT (FT group) and those receiving NT only (NT group). From 2009-2019, 15 women whose fetuses had symptomatic cCMV received FT, while 19 newborns received NT only. In FT group, two newborns died, and two were <18 months old. Neurological outcomes of the remaining 11 infants in FT group were as follows: normal 45.5 %, mild impairments 36.4 %, and severe impairments 18.2 %. In NT group, one newborn died, one's parents refused the follow-up, one was <18 months old, and two had only chorioretinitis as symptoms. Neurological outcomes of the remaining 14 infants in NT group were as follows: normal 21.4 %, mild impairments 14.3 %, and severe impairments 64.3 %. The proportion of infants with severe impairments in FT group was significantly lower than that in NT group (18.2 % vs 64.3 %, p < 0.05). This is the first trial demonstrating that the combination of Ig FT and NT with antiviral drugs may be more effective in improving neurological outcomes of newborns with symptomatic cCMV as compared to NT only.Lead, Dec. 2020, Journal of reproductive immunology, 143, 103263 - 103263, English, International magazine[Refereed]Scientific journal
- 金原出版(株), Dec. 2020, 産婦人科の実際, 69(13) (13), 1605 - 1614, Japanese
- This prospective cohort study aimed to determine clinical factors associated with congenital cytomegalovirus (CMV) infection in pregnancy. Newborns born at a perinatal medical center received PCR analyses for CMV-DNA in their urine with informed consent. Clinical data, including age, maternal fever or flu-like symptoms, complications, ultrasound fetal abnormality, gestational weeks at delivery, and birth weight, were collected. Logistic regression analyses determined clinical findings associated with congenital CMV infection (cCMV). cCMV was diagnosed in 32 of 4380 pregnancies. Univariate and multivariable analyses revealed that age < 25 years old (OR 2.7, 95% CI 1.1-6.6; p < 0.05), the presence of maternal fever or flu-like symptoms (5.4, 2.6-11.2; p < 0.01), ultrasound fetal abnormalities (12.7, 5.8-27.7; p < 0.01), and preterm delivery at less than 34 gestational weeks (2.6, 1.1-6.0; p < 0.05) were independent clinical findings associated with cCMV. A combination of maternal fever/flu-like symptoms, ultrasound fetal abnormalities, or preterm delivery at less than 34 gestational weeks as optimal predictive factors showed 90.6% sensitivity, 66.4% specificity, and a maximum Youden index of 0.57. CMV-DNA tests in the urine of newborns born to mothers with these clinical manifestations may be an effective method in detecting cCMV as a targeted screening with a high sensitivity.Nov. 2020, Scientific reports, 10(1) (1), 19706 - 19706, English, International magazine[Refereed]Scientific journal
- OBJECTIVES: The aim of this study was to evaluate whether vaginal microbiota is associated with threatened premature labor and preterm delivery. METHODS: This prospective study enrolled 64 pregnant women who underwent vaginal microbiome analyses using 16S ribosomal RNA sequence method with informed consent. The 64 pregnant women consisted of 47 women with threatened premature labor and 17 women with other diseases (non-threatened premature labor) in a case-control study. In a cohort study of threatened premature labor group, 23 pregnancies ended in preterm delivery, and the remaining 24 ended in full-term deliveries. The differences in vaginal microbiota between threatened and non-threatened premature labor groups, and between preterm and full-term delivery groups were evaluated. RESULTS: There were no differences in vaginal microbiota between threatened and non-threatened premature labor groups. There were significant differences between preterm and full-term delivery groups in Nugent score [median 3 (range 0-7) vs. 0 (0-4), p < 0.05], percentage of Lactobacillus species [88% (0-100) vs. 99.8% (55.4-100), p < 0.01], the number of bacterial species [3 (1-13) vs. 2 (1-5), p < 0.05], and positivity of Ureaplasma species (61% vs. 17%, p < 0.01). Univariate and multivariable analyses revealed that positivity of Ureaplasma species was a predictive factor of preterm delivery in women with threatened premature labor (OR, 6.5; 95% CI, 1.3-33.0; p < 0.05). CONCLUSION: Increased positivity of Ureaplasma species in vaginal microbiota was a risk factor for preterm delivery among women with threatened premature labor. Vaginal microbiome analysis may identify high risk pregnancies for preterm delivery.Nov. 2020, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 26(11) (11), 1134 - 1138, English, International magazine[Refereed]Scientific journal
- OBJECTIVE: The clinical manifestations of antiphospholipid syndrome (APS) include vascular thrombosis and pregnancy morbidity as well as recurrent pregnancy loss (RPL). However, in more than half of patients with RPL, the cause is never determined. Recently, β2 -glycoprotein I (β2 GPI) complexed with HLA class II molecules (β2 GPI/HLA-DR) was found to be a major autoantibody target in APS. The present study was undertaken to assess the serum levels of autoantibodies against the β2 GPI/HLA II complex as a potential risk factor for RPL in women. METHODS: Serum levels of antiphospholipid antibodies (aPLs), including IgG/IgM anticardiolipin antibodies, IgG/IgM anti-β2 GPI antibodies, and lupus anticoagulant as well as anti-β2 GPI/HLA-DR antibodies, were measured in 227 women with RPL. In this prospective, multicenter, cross-sectional study, women with RPL and their partners underwent HLA-DR immunotyping and analysis to identify potential causes and risk factors associated with RPL. The normal range for anti-β2 GPI/HLA-DR antibody levels was determined using serum samples obtained from a control population of female subjects (208 women of childbearing potential). RESULTS: Of the 227 women with RPL, aPL antibodies were detected in 19.8%, and 52 (22.9%) tested positive for anti-β2 GPI/HLA-DR antibodies. Among the 227 women, 121 (53.3%) had no risk factors for RPL, and among these women with unexplained RPL, 24 (19.8%) were positive for anti-β2 GPI/HLA-DR antibodies. Of the 112 women who had clinical symptoms of APS but did not have levels of aPLs that met the diagnostic criteria for APS, 21 (18.8%) were positive for anti-β2 GPI/HLA-DR antibodies. CONCLUSION: The anti-β2 GPI/HLA-DR antibody is frequently associated with RPL. Detection of these autoantibodies is useful in understanding the pathogenesis of RPL. Our findings may provide potential new therapeutic strategies for addressing RPL in patients with obstetric APS.Lead, Nov. 2020, Arthritis & rheumatology (Hoboken, N.J.), 72(11) (11), 1882 - 1891, English, International magazine[Refereed]Scientific journal
- 「産婦人科の進歩」編集室, Oct. 2020, 産婦人科の進歩, 72(4) (4), 392 - 394, Japanese
- (株)東京医学社, Aug. 2020, 周産期医学, 50(8) (8), 1451 - 1453, Japanese
- INTRODUCTION: Congenital cytomegalovirus infection (CCMVI) may result in neurodevelopmental impairments (NDIs) such as hearing loss, developmental delay, epilepsy, and cerebral palsy. We aimed to investigate the potential for brain magnetic resonance imaging (MRI) to predict NDI in patients with CCMVI. METHODS: We studied infants with CCMVI who were referred to our hospital from April 2010 to October 2018 and underwent a brain MRI within 3 months since birth. We screened for 6 classic presentations of CCMVI including ventriculomegaly, periventricular cysts, hippocampal dysplasia, cerebellar hypoplasia, migration disorders, and white matter abnormalities. Images were interpreted by a blinded pediatric radiologist. NDI was defined as having a developmental quotient <80, hearing dysfunction, blindness, or epilepsy requiring anti-epileptic drugs at approximately 18 months of corrected age. RESULTS: The study involved 42 infants with CCMVI (median gestational age 38 weeks, birthweight 2,516 g). At least one abnormal finding was detected in 28 (67%) infants. Abnormal findings consisted of 3 cerebellar hypoplasia (7%), 7 migration disorders (17%), 26 white matter abnormalities (62%), 12 periventricular cysts (28%), 1 hippocampal dysplasia (2%), and 20 ventriculomegaly (48%). Abnormal findings were significantly more prevalent in infants with clinical symptoms (21/24, 91%) than in those without (7/19, 37%, p < 0.01). For NDI prediction, having ≥2 of ventriculomegaly, periventricular cysts, and white matter abnormality produced the highest Youden index values (0.78). CONCLUSION: Infants with CCMVI with at least 2 of the abovementioned specific brain image abnormalities may be at high risk of developing NDI.Jun. 2020, Neonatology, 117(4) (4), 1 - 7, English, International magazine[Refereed]Scientific journal
- OBJECTIVES: This prospective cohort study aimed to evaluate the efficacy of the universal neonatal urine screening, followed by diagnosis, workup and antiviral therapy for symptomatic congenital cytomegalovirus (CMV) infection to reduce neurological impairments and sequelae. METHODS: Neonates born in three facilities underwent the universal urine screening of PCR analyses for CMV-DNA. Neonates with symptomatic congenital CMV infection (cCMV) received oral valganciclovir (VGCV) of 32 mg/kg/day for six weeks or six months, and were evaluated for neurological outcomes including developmental quotient (DQ) and hearing function at around 18 months of corrected age. RESULTS: cCMV was diagnosed in 56 (0.48%) of 11,736 neonates, consisting of 23 neonates with symptomatic and 33 with asymptomatic cCMV. The incidence of cCMV in the general perinatal medical center (0.69%) was higher than that in the primary maternity hospital (0.23%, p<0.01%). Twenty of the 23 infants with symptomatic cCMV received VGCV therapy, and 19 underwent neurological assessment. Eight neonates (42%) had severe sequelae of DQ < 70, bilateral hearing dysfunction, and/or epilepsy. Four neonates (21%) had mild sequelae of DQ 70-79 or unilateral hearing dysfunction only, and seven (37%) showed normal development without any impairment. CONCLUSIONS: This study on a large scale demonstrated that a series of universal neonatal urine screening, diagnosis, workup, and VGCV therapy for neonates with symptomatic cCMV may decrease neurological impairments, because 58% of the treated infants had normal development or mild sequelae. The universal urine screening likely identifies subclinical symptomatic cCMV. Mothers with fetuses of cCMV seem to be selectively transferred to perinatal medical centers before deliveries.Apr. 2020, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 26(8) (8), 790 - 794, English, International magazine[Refereed]Scientific journal
- (株)診断と治療社, Mar. 2020, 産科と婦人科, 87(Suppl.) (Suppl.), 230 - 235, Japanese
- (株)東京医学社, Jan. 2020, 小児内科, 52(1) (1), 23 - 29, Japanese
- AIM: To evaluate pregnancy outcome and complications in subsequent pregnancies after severe post-partum hemorrhage (PPH) between women with and without a history of uterine artery embolization (UAE). METHODS: Women who had a history of severe PPH, and delivered newborns at ≥22 gestational weeks in subsequent pregnancies were enrolled. Severe PPH was defined as blood loss volume of more than 2000 mL. RESULTS: The blood loss volume (median 1581 mL) in women with UAE (n = 14) was significantly more than that in women without UAE (median 1021 mL, n = 32, P < 0.01), and the recurrence rate of severe PPH in women with UAE (n = 5, 35.7%) was significantly higher than that in women without UAE (n = 3, 9.4%, P < 0.05). There were no significant differences in frequencies of premature delivery, hypertensive disorders of pregnancy, fetal growth restriction, or placenta previa/low lying placenta. Of 14 women with UAE, 7 (50.0%) had abnormally invasive placenta, whereas of 32 women without UAE, none had abnormally invasive placenta. CONCLUSION: Subsequent pregnancies after UAE for severe PPH had high risks for recurrence of severe PPH.Last, Jan. 2020, The journal of obstetrics and gynaecology research, 46(1) (1), 119 - 123, English, International magazine[Refereed]Scientific journal
- BACKGROUND: The aim of this prospective cohort study was to determine clinical factors associated with the occurrence of congenital cytomegalovirus infection (cCMV) in pregnant women. METHODS: Between March 2009 and November 2017, newborns born at a primary maternity hospital received polymerase chain reaction (PCR) analyses for CMV-DNA in their urine with informed consent of the mothers at a low risk. Clinical data, including age, gravidity, parity, body mass index, occupations, maternal fever/flu-like symptoms, pregnancy complications, gestational weeks at delivery, birth weight, and automated auditory brainstem response (AABR), were collected. Logistic regression analyses were performed to determine clinical factors associated with cCMV. RESULTS: cCMV was diagnosed by positive PCR results of neonatal urine in 9 of 4,125 pregnancies. Univariate and multivariable analyses revealed that the presence of fever/flu-like symptoms (odds ratio [OR], 17.9; 95% confidence interval [CI], 3.7-86.7; p<0.001) and threatened miscarriage/premature labor in the second trimester (OR, 6.0; 95%CI 1.6-22.8; p<0.01) were independent clinical factors associated with cCMV. Maternal fever/flu-like symptoms or threatened miscarriage/premature labor in the second trimester had 100% sensitivity, 53.2% specificity, and a maximum Youden index of 0.85. CONCLUSIONS: This cohort study for the first time demonstrated that these clinical factors of pregnant women and newborns were associated with the occurrence of cCMV. This is useful information for targeted screening to assess risks of cCMV in low-risk mothers, irrespective of primary or non-primary CMV infection.Dec. 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 71(11) (11), 2833 - 2839, English, International magazine[Refereed]Scientific journal
- Nov. 2019, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy[Refereed]
- OBJECTIVE: This study aimed to evaluate the neurodevelopmental outcomes of infants with symptomatic congenital cytomegalovirus (SCCMV) disease after antiviral treatment and investigate the symptoms at birth associated with a developmental quotient (DQ) < 70. METHODS: In this prospective study conducted from 2009 to 2018, infants with SCCMV disease who received oral valganciclovir (VGCV; 32 mg/kg/day) for 6 weeks (November 2009 to June 2015) or 6 months (July 2015 to March 2018) were evaluated for their neurodevelopmental outcomes at around 18 months of corrected age. Sequelae were categorized as follows: no impairment with a DQ ≥ 80 and no hearing dysfunction; mild sequelae including unilateral hearing dysfunction or a DQ of 70-79; and severe sequelae with a DQ < 70, bilateral hearing dysfunction requiring hearing aids, blindness or epilepsy requiring anti-epileptic drugs. DQ was assessed using the Kyoto Scale of Psychological Development. Symptoms at birth associated with a DQ < 70 were determined using univariate and receiver operating characteristic curve analyses. RESULTS: Of the 24 treated infants, 21 reached > 18 months of corrected age. Six (29%) were no impairment, 4 (19%) had mild sequelae, and 11 (52%) developed severe sequelae. The symptoms at birth associated with a DQ < 70 were microcephaly and/or small for gestational age. CONCLUSION: In our cohort of infants with SCCMV disease after VGCV treatment, the incidence of severe sequelae at 18 months of corrected age was around 50%. When microcephaly and/or small for gestational age are seen at birth, a low DQ may appear even after oral VGCV treatment.Oct. 2019, Brain & development, 41(9) (9), 743 - 750, English, International magazine[Refereed]Scientific journal
- The aims of this study were to assess the effect of maternal screening for hepatitis B (HB) virus and a perinatal prevention program of mother-to-child transmission, and to identify clinical characteristics and findings associated with HB exacerbation during pregnancy. This prospective cohort study enrolled 3796 pregnant women and their neonates with informed consent. Pregnant women underwent maternal universal screening for HBs antigen (Ag) in the first trimester. If HBs Ag was positive, serum levels of HBe Ag, alanine transaminase (AST), aspartate aminotransferase (ALT), and HB virus (HBV) DNA were measured. All neonates delivered from HBs Ag-positive women were given HB immune globulin and HB vaccine based on the guidelines of the perinatal prevention program. Of the 3796 pregnant women, 40 (1.05%) tested positive for HBs Ag. Three (7.5%) of the 40 HBs Ag-positive women experienced exacerbation of HBV infection during pregnancy. Serum levels of AST (median 776 vs. 22 mIU/ml, p < 0.01), ALT (median 325 vs. 15 mIU/ml, p < 0.01), and HBV-DNA (median 9.1 vs. 5.4 log copies/ml, p < 0.05), and frequencies of HBe Ag-positive (100% vs. 29.7%, p < 0.05) and symptoms of itching or general fatigue (66.7% vs. 0%, p < 0.01) in three women with exacerbation of HBV infection were significantly higher than those in 37 women without exacerbation. There was no case of mother-to-child transmission, suggesting the perinatal HBV prevention program was effective. Levels of HBe Ag, liver enzymes, and HBV-DNA as well as symptoms of itching and general fatigue should be carefully monitored for HBs Ag-positive women during pregnancy and the postpartum period.Last, Aug. 2019, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 25(8) (8), 621 - 625, English, International magazine[Refereed]Scientific journal
- Although cytomegalovirus (CMV) DNA detection in urine is the standard method for diagnosing congenital cytomegalovirus infection (CCMVI), polymerase chain reaction (PCR) is not comprehensively available. Currently, the efficacy of CMV-specific IgM (CMV-IgM) and CMV-specific IgG (CMV-IgG) detection remains unclear. To determine the sensitivity and specificity of CMV-specific antibodies at birth, we investigated CMV-IgM and CMV-IgG titers in CCMVI cases and non-CCMVI controls, with confirmed diagnoses by urine quantitative real-time PCR within 3 weeks after birth. We included 174 infants with suspected CCMVI in whom serological testing was performed within the first 2 weeks after birth during 2012-2018. We classified the participants into a CCMVI group (n = 32) and non-CCMVI group (n = 142) based on their urine PCR results. The CMV-IgM-positive rate was 27/32 (84.4%) in the CCMVI group, compared with 1/142 (0.7%) in the non-CCMVI group (p < 0.0001). The positive CMV-IgG rates were 32/32 (100%) in the CCMVI group and 141/142 (99.3%) in the non-CCMVI group. The positive predictive value for CMV-IgM was high at 96.4% (27/28). This value may be sufficient for clinical use, especially in settings with limited resources where PCR is unavailable. However, CCMVI screening by CMV-IgM alone appears insufficient because of the considerable number of false-negative cases.Jul. 2019, International journal of molecular sciences, 20(13) (13), English, International magazine[Refereed]Scientific journal
- Although cytomegalovirus (CMV) DNA detection in urine is the standard method for diagnosing congenital cytomegalovirus infection (CCMVI), polymerase chain reaction (PCR) is not comprehensively available. Currently, the efficacy of CMV-specific IgM (CMV-IgM) and CMV-specific IgG (CMV-IgG) detection remains unclear. To determine the sensitivity and specificity of CMV-specific antibodies at birth, we investigated CMV-IgM and CMV-IgG titers in CCMVI cases and non-CCMVI controls, with confirmed diagnoses by urine quantitative real-time PCR within 3 weeks after birth. We included 174 infants with suspected CCMVI in whom serological testing was performed within the first 2 weeks after birth during 2012-2018. We classified the participants into a CCMVI group (n = 32) and non-CCMVI group (n = 142) based on their urine PCR results. The CMV-IgM-positive rate was 27/32 (84.4%) in the CCMVI group, compared with 1/142 (0.7%) in the non-CCMVI group (p < 0.0001). The positive CMV-IgG rates were 32/32 (100%) in the CCMVI group and 141/142 (99.3%) in the non-CCMVI group. The positive predictive value for CMV-IgM was high at 96.4% (27/28). This value may be sufficient for clinical use, especially in settings with limited resources where PCR is unavailable. However, CCMVI screening by CMV-IgM alone appears insufficient because of the considerable number of false-negative cases.Jul. 2019, International journal of molecular sciences, 20(13) (13), English, International magazine[Refereed]Scientific journal
- 日本女性栄養・代謝学会, Jun. 2019, 日本女性栄養・代謝学会誌, 25, 59 - 60, Japanese胎児甲状腺腫を来たしたT3優位型バセドウ病合併妊娠の2例
- 日本女性栄養・代謝学会, Jun. 2019, 日本女性栄養・代謝学会誌, 25, 67 - 68, Japaneseメトホルミンが著効したインスリン抵抗症合併妊娠の1例
- Primary infection with Toxoplasma gondii (T. gondii) during pregnancy may cause congenital infection of the infant. This study evaluated whether screening using IgG avidity and multiplex-nested polymerase chain reaction (PCR) methods was effective for detecting a high-risk pregnancy for congenital T. gondii infection. In a prospective cohort study serum T. gondii IgG avidity was measured in 469 pregnant women who had a positive test for T. gondii antibody plus a positive or equivocal test for IgM. Multiplex-nested PCR for T. gondii DNA on amniotic fluid, maternal blood, and neonatal blood was performed with informed consent. Low (<30%), borderline (30-35%), and high (>35%) IgG avidity indices were found in 104 (22.2%), 30 (6.4%), and 305 (71.4%), respectively. A total of 12 cases had a positive PCR test for amniotic fluids of the prenatal amniocentesis or at birth, or neonatal blood. Seven of the 12 cases were diagnosed as having congenital T. gondii infection, and they had low IgG avidity indices. Congenital T. gondii infection screening using of IgG avidity and multiplex-nested PCR methods for pregnant women with a positive test for T. gondii antibody plus a positive or equivocal test for T. gondii IgM was useful for detecting a high-risk pregnancy and diagnosing congenital T. gondii infection.Jun. 2019, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 25(6) (6), 427 - 430, English, International magazine[Refereed]Scientific journal
- 「産婦人科の進歩」編集室, May 2019, 産婦人科の進歩, 71(2) (2), 103 - 108, Japanese
- (公社)日本産科婦人科学会, May 2019, 日本産科婦人科学会雑誌, 71(5) (5), 643 - 651, Japanese【産婦人科感染症の最前線】風疹,サイトメガロウイルス,パルボウイルスB19
- The aim of this prospective cohort study was to evaluate clinical factors associated with pregnancy outcomes in women with recurrent pregnancy loss (RPL). Women with a history of two or more pregnancy losses underwent workups for clinical factors of RPL and their pregnancies were followed-up with informed consent. Two hundred eleven (81.5%) of 259 women with RPL became pregnant. The multivariable analyses demonstrated that age (p < .01, OR 0.9, 95%CI 0.97-0.83), uterine abnormality (p < .05, OR 0.3, 95%CI 0.11-0.8), and protein C (PC) deficiency (p < .01, OR 0.14, 95%CI 0.03-0.6) were independent factors for becoming pregnancy in women with RPL. The number of previous pregnancy loss (p < .01, OR 0.57, 95%CI 0.43-0.75) and natural killer (NK) cell activity ≥33% (p < .01, OR 0.31, 95%CI 0.13-0.73) were independent factors for live birth in the subsequent pregnancy. Advanced age, the presence of uterine abnormality, and PC deficiency were risk factors for reduced pregnancy rate in women with RPL. Increased number of previous pregnancy loss and high NK cell activity were risk factors for miscarriage in the subsequent pregnancy. These results involve important information and are helpful for clinical practitioners.Apr. 2019, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 35(10) (10), 1 - 6, English, International magazine[Refereed]Scientific journal
- Although earlier studies have shown that antiviral treatment regimens using valganciclovir (VGCV) improved hearing function in some infants with congenital cytomegalovirus (CMV) infection; its efficacy on the severity of hearing dysfunction is unclear. We conducted a prospective study among 26 infants with congenital CMV infections from 2009 to 2018. Oral VGCV (32 mg/kg/day) was administered for 6 weeks (November 2009 to June 2015; n = 20) or 6 months (July 2015 to March 2018, n = 6). Hearing function was evaluated by measuring the auditory brainstem response before VGCV treatment and at 6 months. Hearing dysfunction, defined as a V-wave threshold >40 dB, was categorized into: most severe, ≥91 dB; severe, 61⁻90 dB; and moderate, 41⁻60 dB. Hearing improvement was defined as a decrease of ≥20 dB from the pretreatment V-wave threshold. Of 52 ears in 26 infants with congenital CMV infection, 29 (56%) had hearing dysfunction, and of 29 ears, 16 (55%) improved after VGCV treatment. Although, 16 (84%) of 19 ears with moderate or severe hearing dysfunction improved after treatment (p < 0.001), 10 ears with the most severe form did not. In conclusion, VGCV treatment is effective in improving moderate and severe hearing dysfunction in infants with congenital CMV infection.Mar. 2019, International journal of molecular sciences, 20(6) (6), English, International magazine[Refereed]Scientific journal
- Human cytomegalovirus (CMV) is a common cause of congenital infection that may lead to severe long-term sequelae. Because there are no established vaccines, fetal interventions or neonatal treatments, neither maternal nor neonatal screening is recommended. However, recent studies have indicated that early antiviral treatment may improve neurological outcomes in symptomatic infants with congenital infection. Therefore, prenatal detection may be important in newborns at high risk of such infection. Polymerase chain reaction for CMV DNA in the amniotic fluid is considered the gold standard for diagnosis of intrauterine infection, but its use is limited because amniocentesis is an invasive procedure. In a prospective cohort study, we have reported that the presence of CMV DNA in secretions of the maternal uterine cervix were predictive of congenital infection in groups at high risk. However, we also recently demonstrated that maternal serological screening for primary CMV infection using specific immunoglobulin G, the immunoglobulin G avidity index or specific immunoglobulin M can overlook many cases. Previous research has indicated that the combination of early detection by universal neonatal screening of urinary CMV DNA combined with early antiviral therapy can improve outcomes in infants with symptomatic congenital infection. In this article, we review the current state of maternal and neonatal screening for congenital CMV infection.Lead, Mar. 2019, The journal of obstetrics and gynaecology research, 45(3) (3), 514 - 521, English, International magazine[Refereed][Invited]Scientific journal
- Neonatal Alloimmune Thrombocytopenia: A Report of Four Cases.Antibodies against fetal platelet alloantigens in maternal blood cause neonatal alloimmune thrombocytopenia (NAIT). We encountered four newborns with NAIT from three women. A woman carried anti-human platelet antigen (HPA)-1a antibody, and vaginally delivered a newborn who had subarachnoid hemorrhage and platelet transfusions. She delivered the second newborn by a cesarean section who had no symptom. The second woman carried anti-human leukocyte antigen-A2 antibody and vaginally delivered a newborn who had no symptom. The third woman with a history of recurrent pregnancy losses carried anti-HPA-4b antibody, and delivered a newborn by a cesarean section who received platelet transfusions and immunoglobulin infusions. Antiplatelet antibody screening may be helpful in women who have a history of blood transfusion, or previous neonates with thrombocytopenia or intracranial hemorrhage.Mar. 2019, The Kobe journal of medical sciences, 64(6) (6), E197 - E199, English, Domestic magazine[Refereed]Scientific journal
- (株)診断と治療社, Feb. 2019, 産科と婦人科, 86(2号) (2号), 223 - 229, Japanese[Invited]Scientific journal
- Fetal Primary Small Bowel Volvulus Associated with Acute Gastric Dilatation Detected by Ultrasonography.Fetal intestinal volvulus is a rare condition, and fetal diagnosis of this disease is still challenging, especially in primary cases not accompanied by other comorbidities, such as intestinal malformations. Herein, we report a case of fetal primary small bowel volvulus associated with acute gastric dilatation detected by ultrasonography. We speculate that the mechanism of acute gastric dilatation in our case was peristatic malfunction of the whole intestine caused by a strangulated ileus resulting from fetal intestinal volvulus. In conclusion, acute gastric dilatation detected by fetal ultrasound can indicate the fetal intestinal volvulus.Jan. 2019, The Kobe journal of medical sciences, 64(4) (4), E157-E159 - E159, English, Domestic magazine[Refereed]Scientific journal
- INTRODUCTION: Cytomegalovirus (CMV) infection is the most common cause of congenital viral infections in humans. The unusual structure of the placenta plays a pivotal role in CMV transmission from mothers to fetuses. The aim of this study was to evaluate the histopathological findings of placentas with congenital CMV infections. METHODS: We obtained placental specimens from 35 women who had newborns with congenital CMV infections. Placental specimens, extraplacental membranes, and umbilical cords were stained with hematoxylin and eosin, and subjected to immunohistochemical analysis. We evaluated the localization of CMV-infected cells and other histological parameters. RESULTS: Thirty (86%) of the 35 placentas tested positive for CMV-infected cell proteins by immunohistochemistry. A majority of CMV-positive cells were present in fibroblasts and endothelial cells in the villi. The number of CMV-infected cells was inversely correlated to gestational age at delivery. The frequency of chronic villitis (65% vs. 11%; p < 0.01) and changes of the villi (38% vs. 0%; p < 0.05) in the placentas from mothers with symptomatic congenital CMV infections was higher than those observed in samples from mothers with asymptomatic congenital infections. The frequency of changes of the decidua (43% vs. 5%; p < 0.01) in the placentas from mothers with non-primary CMV infections was higher than those from mothers with primary infections. DISCUSSION: Chronic villitis and changes of the villi were associated with symptomatic congenital CMV infections. The changes of the decidua were associated with congenital CMV infections, in mothers with non-primary CMV infections.Jan. 2019, Placenta, 75, 62 - 67, English, International magazine[Refereed]Scientific journal
- 兵庫県母性衛生学会, Dec. 2018, 兵庫県母性衛生学会雑誌, (27号) (27号), 67 - 68, Japanese妊婦のB型肝炎スクリーニングと垂直感染予防[Refereed]Scientific journal
- Dec. 2018, 日本産科婦人科学会雑誌, 70(12号) (12号), 2573 - 2584, Japanese生殖・周産期分野の前方視的研究から得られた最新の知見と先制医療への展望 妊婦・新生児スクリーニング前向き研究に基づく母子感染の先制医療[Invited]Symposium
- Early diagnosis and treatment of infants with symptomatic congenital cytomegalovirus (CMV) infection may improve neurological outcomes. For this reason, prenatal detection of newborns at high risk for congenital CMV infection is important. A polymerase chain reaction (PCR) assay for CMV DNA in the amniotic fluid is the gold standard for the diagnosis of intrauterine CMV infection; however, amniocentesis is an invasive procedure. Recently, we have found that the presence of CMV DNA in the maternal uterine cervical secretion is predictive of the occurrence of congenital CMV infection in CMV immunoglobulin M (IgM)-positive pregnant women. In contrast, we have suggested that maternal serological screening for primary CMV infection using CMV-specific immunoglobulin G (IgG), the IgG avidity index, or CMV-specific IgM overlooks a number of newborns with congenital CMV infection. We will review current knowledge of the potential biomarkers for predicting congenital CMV infection.Lead, Nov. 2018, International journal of molecular sciences, 19(12) (12), English, International magazine[Refereed][Invited]Scientific journal
- The aim of this nested case-control study was to evaluate clinical factors associated with the occurrence of congenital cytomegalovirus (CMV) infection in pregnant women with non-primary CMV infection. In a cohort study of CMV screening for 2193 pregnant women and their newborns, seven newborns with congenital CMV infection were identified among 1287 pregnant women with non-primary CMV infection that was defined as negative IgM and positive IgG with IgG avidity index >45%. In the 1287 women with non-primary CMV infection, clinical findings and complications were compared between pregnancies with and without congenital CMV infection. Clinical factors associated with the occurrence of congenital CMV infection were evaluated. The birth weight of newborns with congenital CMV infection was less than that of newborns without congenital infection (p < 0.05). Univariate logistic regression analyses demonstrated that threatened premature delivery (OR 10.6, 95%CI 2.0-55.0; p < 0.01) and multiple pregnancy (OR 7.1, 95%CI 1.4-37.4; p < 0.05) were associated with congenital infection. Multivariable logistic regression analyses demonstrated that threatened premature delivery (OR 8.4, 95%CI 1.5-48.1; p < 0.05) was a single risk factor for congenital CMV infection in pregnant women with non-primary CMV infection. This study revealed for the first time that threatened premature delivery was associated with the occurrence of congenital CMV infection in pregnant women with non-primary CMV infection, the pathophysiology of which may be closely associated with CMV reactivation during pregnancy.Sep. 2018, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 24(9) (9), 702 - 706, English, International magazine[Refereed]Scientific journal
- 「産婦人科の進歩」編集室, Aug. 2018, 産婦人科の進歩, 70(3) (3), 270 - 277, Japanese在胎30週未満の胎児発育不全児における予後不良に関連する因子の検討[Refereed]Scientific journal
- PURPOSE: To justify a classification system for angiographic images of uterine artery embolization (UAE) for postpartum hemorrhage (PPH) and identify new risk factors associated with failed embolization. MATERIALS AND METHODS: A retrospective analysis of 63 consecutive patients who underwent UAE for severe PPH was performed. Uterine artery angiography (UA) before embolization was classified into two types: type 1 was defined as complete staining and type 2 was defined as partial staining of the uterine arteries. The clinical outcome, UA classification, and other possible factors previously reported were evaluated. Univariate and multivariate analyses were performed to determine the factors related to clinical outcomes. RESULTS: Sixty-three patients were enrolled (type 1, 22; type 2, 41). The clinical success rates of the primary UAE session were 90.9% (20/22) for type 1 and 61.0% (25/41) for type 2 (p = 0.018). Univariate and multivariate analyses demonstrated that the only UA classification was significantly associated with primary UAE failure (p = 0.033). CONCLUSIONS: The UA classification is an independent predictive factor of the clinical success rate of the primary UAE session for PPH; thus, it is an intuitive and optimal predictor for interventional radiologists to decide whether additional therapy is necessary.Jun. 2018, Japanese journal of radiology, 36(6) (6), 394 - 400, English, Domestic magazine[Refereed]Scientific journal
- Purpose: This study aimed to assess the efficacy of high-dose i.v. immunoglobulin (HIVIg) therapy in pregnant women with antiphospholipid syndrome (APS) secondary to systemic lupus erythematosus with a history of pregnancy failure, despite receiving low-dose aspirin plus unfractionated heparin therapy, of which condition being designated as "aspirin-heparin-resistant APS" (AHRAPS). Methods: The HIVIg therapy (20 g/d, 5 days) was performed for the pregnancies of five women with AHRAPS. Results: Five of the eight pregnancies ended in live births. The gestational ages of delivery in four of the five pregnancies were extended, compared with previous pregnancies. The HIVIg therapy was considered to be successful for these four pregnancies. Excluding one pregnancy that ended in miscarriage with an abnormal chromosome karyotype of the villi, the HIVIg therapy was considered to be successful in four (57.1%) of the seven pregnancies of the women with AHRAPS. Although all the live newborns were prematurely delivered, no adverse effect of the HIVIg therapy was observed. Conclusions: The HIVIg therapy might be beneficial as an immune modifier for pregnant women with AHRAPS. However, the precise indication of which women with AHRAPS who should receive HIVIg therapy remains unknown.Apr. 2018, Reproductive medicine and biology, 17(2) (2), 149 - 154, English, Domestic magazine[Refereed]Scientific journal
- INTRODUCTION: Placenta previa (PP) is one of the most significant risk factors for adherent placenta (AP). The aim of this study was to evaluate the diagnostic efficacy of a novel scoring system for predicting AP in pregnant women with PP. METHODS: This prospective cohort study enrolled 175 women with PP. The placenta previa with adherent placenta score (PPAP score) is composed of 2 categories: (1) past history of cesarean section (CS), surgical abortion, and/or uterine surgery; and (2) ultrasonography and magnetic resonance imaging findings. Each category is graded as 0, 1, 2, or 4 points, yielding a total score between 0 and 24. When women with PP had PPAP score ≥8, they were considered to be at a high risk for AP and received placement of preoperative internal iliac artery occlusion balloon catheters. If they were found to have AP during CS, they underwent hysterectomy or placenta removal using advanced bipolar with balloon catheter occlusion. The predictive accuracy of PPAP score was evaluated. RESULTS: In total, 23 of the 175 women with PP were diagnosed as having AP, histopathologically or clinically. Twenty-one of 24 women with PPAP score ≥8 had AP, whereas two of 151 women with PPAP score <8 had AP. The scoring system yielded 91.3% sensitivity, 98.0% specificity, 87.5% positive predictive value, and 98.7% negative predictive value for predicting AP in women with PP. DISCUSSION: This prospective study demonstrated that PPAP scoring system may be useful for predicting AP in women with PP.Lead, Apr. 2018, Placenta, 64, 27 - 33, English, International magazine[Refereed]Scientific journal
- A Case of Congenital Complete Atrioventricular Block Treated with Transdermal TulobuterolCongenital complete atrioventricular block (CCAVB) is a condition in which the atria and ventricles beat independently of each other. CCAVB cases require permanent pacemaker implantation until adulthood. Nevertheless, consensus regarding postnatal medical therapy for bradycardia has not been reached. Here we report the case of a newborn with CCAVB, whose intractable bradycardia was successfully treated with transdermal tulobuterol. Tulobuterol is a selective β2-adrenoceptor agonist, widely used safely as bronchodilator in children. It also has positive inotropic and chronotropic effect via β1-adrenoceptors. We believe the tulobuterol patch can be used as an optional therapy for CCAVB where pacemaker implantation is not available.Apr. 2018, Kobe J Med Sci, 63(4) (4), E109 - E112, English, Domestic magazine[Refereed]Scientific journal
- The aim of this prospective study was to determine clinical factors associated with adverse pregnancy outcomes in women with systematic lupus erythematosus (SLE). Fifty-six pregnancies from 46 women with SLE were enrolled. Risk factors for pregnancy loss, premature delivery, hypertensive disorders of pregnancy (HDP), and light-for-date neonate (LFD), were evaluated. Univariate and multivariate logistic regression analyses revealed a history of two or more pregnancy losses before 10 gestational weeks (GW) (OR 11.5, 95%CI 1.72-76.8) as a risk factor for pregnancy loss; low levels of blood complements (OR 7.55, 95%CI 1.10-51.9) and antiphospholipid syndrome (OR 26.5, 95%CI 3.17-219) as risk factors for premature delivery before 37 GW; SLEDAI score at conception (OR 1.68, 95%CI 1.05-2.68) and positive tests for two or more antiphospholipid antibodies (OR 6.89, 95%CI 1.13-41.9) as risk factors for premature delivery before 34 GW; prednisolone therapy >14mg/day (OR 7.55, 95%CI 1.10-51.9) as a risk factor for HDP; and low dose aspirin therapy (OR 0.21, 95%CI 0.05-0.97) decreased the risk for LFD neonate. These results have important implications for clinicians managing SLE complicated pregnancy.Feb. 2018, Journal of reproductive immunology, 125, 39 - 44, English, International magazine[Refereed]Scientific journal
- Lead, 2018, In Tec, 85 - 94Management of Placenta Accreta in Pregnancy with Placenta Previa.[Refereed][Invited]In book
- Blackwell Publishing Ltd, Jan. 2018, British Journal of Dermatology, 178(1) (1), 272 - 275, English[Refereed]Scientific journal
- Nov. 2017, FRONTIERS IN PEDIATRICS, 5, 241, English[Refereed]Scientific journal
- Background: The aim of this prospective cohort study was to evaluate the efficacy of maternal screening for congenital cytomegalovirus infection (CCI) using cytomegalovirus (CMV) immunoglobulin G (IgG) and the IgG avidity index (AI). Methods: Pregnant women underwent screening of CMV IgG and AI measurements. IgG-negative women underwent remeasurement of IgG after educational intervention. Women with an AI ≤45% received further examinations, including measurement of CMV IgM. All newborns received polymerase chain reaction analyses of the urine, and CCI was diagnosed by the detection of CMV-DNA in the urine. Primary infection was defined as an AI <35% and/or positive IgM (>1.20 index). Serum samples from women with an AI >45% were stored, and the IgM levels were measured after delivery. The efficacy of AI and IgM for CCI screening was compared. Results: A total of 1562 (71.2%) women tested positive for IgG. In this study, 10 newborns with CCI were detected. The presence of infection in 3 newborns from mothers with primary infection was predicted by screening of IgG and AI <35%. However, infection in 7 newborns from women with nonprimary infection could not be predicted by screening of CMV IgG, AI <35%, or IgM. The application of an AI <35% for CCI screening yielded 22.2% sensitivity, 95.0% specificity, 2.5% positive predictive value, and 99.5% negative predictive value and was similar to that of IgM (11.1% sensitivity, 93.2% specificity, 0.9% positive predictive value, and 92.7% negative predictive value). Conclusions: Maternal screening using CMV IgG and AI can identify pregnancies with CCI from primary infection, but overlooks a number of those from nonprimary infection.Lead, Oct. 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 65(10) (10), 1652 - 1658, English, International magazine[Refereed]Scientific journal
- Lead, Jun. 2017, Expert review of molecular diagnostics, 17(6) (6), 535 - 537, English, International magazine[Refereed][Invited]
- (一社)日本糖尿病学会, Apr. 2017, 糖尿病, 60(Suppl.1) (Suppl.1), S - 429, Japanese持続血糖モニターを用いた妊娠糖尿病患者における分娩中の血糖動態についての検討
- BioMed Central Ltd., Mar. 2017, Journal of Medical Case Reports, 11(1) (1), 66, English[Refereed]Scientific journal
- Lead, Jan. 2017, CLINICAL INFECTIOUS DISEASES, 64(2) (2), 159 - 165, English[Refereed]Scientific journal
- Nov. 2016, Reproductive Immunology and Biology, 31(1-2号) (1-2号), 113, Japanese妊婦のサイトメガロウイルス抗体スクリーニングの有用性Research society
- Nov. 2016, Reproductive Immunology and Biology, 31(1-2号) (1-2号), 114, Japanese妊娠中にパルボウイルスB19に感染した6例[Refereed]Research society
- Nov. 2016, Reproductive Immunology and Biology, 31(1-2号) (1-2号), 105, Japanese先天性アンチトロンビン欠乏症を合併した20名23妊娠の管理方法と臨床経過[Refereed]Research society
- 日本生殖免疫学会, Nov. 2016, Reproductive Immunology and Biology, 31(1-2号) (1-2号), 110 - 110, Japanese抗リン脂質抗体症候群における抗Prothrombin/HLA-DR抗体Research society
- Nov. 2016, Reproductive Immunology and Biology, 31(1-2号) (1-2号), 131, Japaneseリスク因子不明習慣流産に対する100gおよび60g免疫グロブリン療法の効果[Refereed]Research society
- Nov. 2016, Reproductive Immunology and Biology, 31(1-2号) (1-2号), 109, Japaneseアスピリン、ヘパリン併用療法抵抗性のAPS合併妊娠に対する大量免疫グロブリン療法[Refereed]Research society
- (一社)日本糖尿病・妊娠学会, Oct. 2016, 糖尿病と妊娠, 16(3号) (3号), S - 66, Japaneseインスリン使用/非使用GDM症例におけるインスリン分泌能・感受性指標の比較Research society
- John Wiley and Sons Inc., Sep. 2016, Journal of Magnetic Resonance Imaging, 44(3) (3), 573 - 583, English[Refereed]Scientific journal
- Sep. 2016, 周産期学シンポジウム, (34号) (34号), 71 - 75, Japanese母児の予後からみた娩出のタイミングと方法 癒着胎盤予測スコアを用いた前置胎盤の手術管理[Refereed][Invited]Symposium
- Jun. 2016, 日本産婦人科・新生児血液学会誌, 26(1号) (1号), S - 15-S-16, Japanese本邦におけるパルボウイルスB19母子感染の実態Research society
- Jun. 2016, 日本周産期・新生児医学会雑誌, 52(2号) (2号), 412, Japanese母子感染対策の最前線2016年 サイトメガロウイルスResearch society
- Objective: We aimed to evaluate prognostic factors of outcome in neonates born at less than 29 weeks of gestation (GW) because of threatened premature labor. Patients and Methods: This was a retrospective study including 43 neonates who were born in our hospital between 2005 and 2014. These neonates were divided into two groups according to the outcome: good (healthy) and poor (handicapped or dead). We examined the following factors: GW at delivery, the presence of rupture of the membranes, maximum maternal leukocyte count 15000/μl and serum CRP level 2.0 mg/dl, highest maternal body temperature 37.5 degrees, maternal steroid administration, male sex, standard deviation of birthweight, and stage of chorioamnionitis grade 2. The prognostic factors for poor outcome were determined by uni- and multivariate logistic regression analyses. Results: Logistic regression analyses showed that GW at delivery was an independent prognostic factor of outcome of neonates (OR, 0.5; 95% CI, 0.3-0.9; p=0.03). Conclusions: This study suggests that the prognosis of neonates who are born at less than 29 GW because of threatened premature labor is associated with earlier GW at delivery. [Adv Obstet Gynecol, 68(2) : 69-74, 2016 (H28.5)]THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, May 2016, 産婦人科の進歩, 68(2号) (2号), 69 - 74, Japanese[Refereed]Scientific journal
- Klippel-Trenaunay-Weber syndrome (KTWS) is a rare disorder characterized by extensive cutaneous vascular malformation, venous varicosities, hemangiomas, and hypertrophy of soft or bony tissue. We herein report a case of a pregnant woman complicated with KTWS. A 23-year-old woman (gravida 1, para 0) underwent anticoagulation therapy with low-dose aspirin and unfractionated heparin from the first trimester because of the presence of hemangiomas. We assessed the location of the hemangiomas by pelvic and spinal magnetic resonance imaging (MRI) at gestational age (GA) of 27 and 35 weeks. A cesarean delivery with spinal anesthesia was supposed to be done based on the initial assessment of hemangiomas at GA of 27 weeks. However, MRI at GA at 35 weeks revealed hemangiomas developed newly around the lumbar. We therefore performed a cesarean delivery under general anesthesia at GA at 37 weeks. During the operation, we examined the location of the hemangiomas in abdominal wall by transabdominal ultrasound and avoided injuring the hemangiomas. The patient delivered a 2518g healthy female infant and received anticoagulation therapy for six weeks after delivery, preventing thrombosis and embolism. In conclusion, anticoagulation therapy and decision of style and method of parturient based on the assessment of the location of hemangiomas by MRI, ultrasonography and bronchoscopy may enable safer perinatal management for pregnancies complicated by KTWS. [Adv Obstet Gynecol, 68 (2) : 93-98, 2016 (H28.5)]THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, May 2016, 産婦人科の進歩, 68(2号) (2号), 93 - 98, Japanese[Refereed]Scientific journal
- Feb. 2016, BRAIN & DEVELOPMENT, 38(2) (2), 209 - 216, English[Refereed]Scientific journal
- Feb. 2016, BRAIN & DEVELOPMENT, 38(2) (2), 188 - 195, English[Refereed]Scientific journal
- 2016, Reproductive Immunology and Biology, 31, 24 - 31, Japaneseβ2-グリコプロテインI /HLA class II 複合体が抗リン脂質抗体症候群の病態に関連する[Refereed][Invited]Scientific journal
- Jan. 2016, 日本周産期・新生児医学会雑誌, 51(別冊) (別冊), 24 - 25, Japanese癒着胎盤予測スコアを用いた前置胎盤の手術管理Research society
- 2016, GYNECOLOGICAL ENDOCRINOLOGY, 32(8) (8), 672 - 674, English[Refereed]Scientific journal
- 2016, GYNECOLOGICAL ENDOCRINOLOGY, 32(10) (10), 803 - 806, English[Refereed]Scientific journal
- Dec. 2015, 兵庫県母性衛生学会雑誌, (24号) (24号), 39 - 42, Japanese電撃性紫斑病(重症型先天性プロテインC欠損症)の出生前診断を行った2例[Refereed]Scientific journal
- Nov. 2015, INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 34(6) (6), 584 - 589, English[Refereed]Scientific journal
- Lead, Sep. 2015, JOURNAL OF INFECTION AND CHEMOTHERAPY, 21(9) (9), 668 - 671, English[Refereed]Scientific journal
- This study aimed to evaluate changes in natural killer (NK) cell activity and the percentage of monocytes in women with recurrent miscarriage who received medium-dose intravenous immunoglobulin (IVIg) therapy. Fourteen women with a history of six or more recurrent miscarriages of unexplained etiology received 60-g IVIg therapy (20 g daily, for three days) during early gestation. NK cell activity in the peripheral blood decreased to 12% one week after therapy compared with before therapy (median, 22%, P < 0.001) and the percentage of monocytes increased from 5.2% to 7.5% (P < 0.005). Four pregnancies ended in live births of healthy neonates, whereas the other ten pregnancies ended in miscarriages. Excluding one miscarriage with a chromosomal abnormality, the live birth rate was 30.8% (4/13). The rate of reduction of NK cell activity in the success group (-58.8%) tended to be greater than that in the failure group (-14.8%, P = 0.057).Jun. 2015, Journal of reproductive immunology, 109, 48 - 51, English, International magazine[Refereed]Scientific journal
- May 2015, JOURNAL OF CLINICAL VIROLOGY, 66, 44 - 47, English[Refereed]Scientific journal
- OBJECTIVE: Adherent placenta is a life-threatening condition in pregnancy, and is often complicated by placenta previa. The aim of this prospective study was to determine prenatal imaging findings that predict the presence of adherent placenta in pregnancies with placenta previa. STUDY DESIGN: The study included 58 consecutive pregnant women with placenta previa who underwent both ultrasonography and magnetic resonance imaging prenatally. Ultrasonographic findings of anterior placental location, grade 2 or higher placental lacunae (PL≥G2), loss of retroplacental hypoechoic clear zone (LCZ) and the presence of turbulent blood flow in the arteries were evaluated, in addition to MRI findings. Forty-three women underwent cesarean section alone; 15 women with adherent placenta underwent cesarean section followed by hysterectomy with pathological examination. To determine imaging findings that predict adherent placenta, univariate and multivariate logistic regression analyses were performed. RESULTS: Univariate logistic regression analyses demonstrated that anterior placental location, PL≥G2, LCZ, and MRI were associated with the presence of adherent placenta. Multivariate analyses revealed that LCZ (p<0.01, odds ratio 15.6, 95%CI 2.1-114.6) was a single significant predictor of adherent placenta in women with placenta previa. CONCLUSION: This prospective study demonstrated for the first time that US findings, especially LCZ, might be useful for identifying patients at high risk for adherent placenta among pregnant women with placenta previa.Lead, Apr. 2015, European journal of obstetrics, gynecology, and reproductive biology, 187, 41 - 4, English, International magazine[Refereed]Scientific journal
- Mar. 2015, JOURNAL OF INFECTION AND CHEMOTHERAPY, 21(3-4) (3-4), 161 - 164, English[Refereed]Scientific journal
- Mar. 2015, JOURNAL OF PERINATAL MEDICINE, 43(2) (2), 239 - 243, English[Refereed]Scientific journal
- Kobe University School of Medicine, 2015, Kobe Journal of Medical Sciences, 61(3) (3), E86 - E92, EnglishChanges in gestational weight gain and birth weight in women who delivered at Hyogo Prefectural Kaibara hospital in Tamba, Japan during 27 years[Refereed]Scientific journal
- Lead, American Society of Hematology, 2015, Blood, 125(18) (18), 2835 - 2844, English[Refereed]Scientific journal
- (公社)日本産科婦人科学会, Dec. 2014, 日本産科婦人科学会雑誌, 66(12付録) (12付録), 1 - 15, Englishサイトメガロウイルス妊娠管理マニュアルScientific journal
- BACKGROUND: Cytomegalovirus (CMV) causes congenital infection with high mortality and morbidity rates in affected neonates. OBJECTIVES: To evaluate the maternal IgG avidity value for the prediction of congenital CMV infection. STUDY DESIGN: The serum IgG avidity in all mothers was measured, and the urine of their neonates was assessed for CMV DNA in a prospective cohort study. RESULTS: Of 759 women with a positive test for CMV IgG, 14 had congenital CMV infection. CMV IgG avidity indices in the congenital infection group (median 35.1%) were significantly lower than those in the non-congenital infection group (70.4%). A cutoff value of <40% IgG avidity index with 96.1% specificity and 64.3% sensitivity for congenital infection was determined by receiver operating characteristic curve analyses. The highest sensitivity (88.9%), 96.2% specificity, 27.6% positive predictive value, 99.8% negative predictive value, and 96.1% accuracy were found when IgG avidity was measured in <28 weeks of gestation. CONCLUSION: The IgG avidity measurement with a cutoff value of <40% IgG avidity index might be helpful in predicting congenital CMV infection, especially in <28 weeks of gestation.Nov. 2014, Journal of perinatal medicine, 42(6) (6), 755 - 9, English, International magazine[Refereed]Scientific journal
- Prophylactic intravenous immunoglobulin injections to mothers with primary cytomegalovirus infection.The aim of this trial study was to assess the preventive efficacy of immunoglobulin with a high titer of anti-CMV antibody for mother-to-fetus cytomegalovirus (CMV) transmission among pregnant women with primary/acute CMV infection. The primary CMV infection in mothers was diagnosed by a positive test for CMV IgM and/or low IgG avidity. Intact type immunoglobulin with a high titer of anti-CMV antibody was injected intravenously at a dosage of 2.5-5.0 g/day for consecutive 3 days to mothers with primary CMV infection. Four pregnant women were enrolled. One pregnancy ended in no congenital infection, while two pregnancies ended in congenital CMV infection. The other one pregnancy was terminated. The mother-to-fetus CMV transmission rate was found to be high as 66.7% (2/3). This preliminary result suggests that intravenous immunoglobulin injections are not effective for the prevention of mother-to-fetus CMV transmission in the present protocol.Lead, Jul. 2014, The Kobe journal of medical sciences, 60(2) (2), E25-9 - 9, English, Domestic magazine[Refereed]Scientific journal
- May 2014, CONGENITAL ANOMALIES, 54(2) (2), 100 - 103, English[Refereed]Scientific journal
- Apr. 2014, EXPERIMENTAL & CLINICAL CARDIOLOGY, 20(6) (6), 145 - 159, EnglishManagement of Thromboembolism in Pregnant Women with Inherited Antithrombin[Refereed]Scientific journal
- Apr. 2014, EUROPEAN RADIOLOGY, 24(4) (4), 881 - 888, English[Refereed]Scientific journal
- Specific HLA class II alleles are strongly associated with susceptibility to rheumatoid arthritis (RA); however, how HLA class II regulates susceptibility to RA has remained unclear. Recently, we found a unique function of HLA class II molecules: their ability to aberrantly transport cellular misfolded proteins to the cell surface without processing to peptides. Rheumatoid factor (RF) is an autoantibody that binds to denatured IgG or Fc fragments of IgG and is detected in 70-80% of RA patients but also in patients with other diseases. Here, we report that intact IgG heavy chain (IgGH) is transported to the cell surface by HLA class II via association with the peptide-binding groove and that IgGH/HLA class II complexes are specifically recognized by autoantibodies in RF-positive sera from RA patients. In contrast, autoantibodies in RF-positive sera from non-RA individuals did not bind to IgGH/HLA class II complexes. Of note, a strong correlation between autoantibody binding to IgG complexed with certain HLA-DR alleles and the odds ratio for that allele's association with RA was observed (r = 0.81; P = 4.6 × 10(-5)). Our findings suggest that IgGH complexed with certain HLA class II alleles is a target for autoantibodies in RA, which might explain why these HLA class II alleles confer susceptibility to RA.Mar. 2014, Proceedings of the National Academy of Sciences of the United States of America, 111(10) (10), 3787 - 92, English, International magazine[Refereed]Scientific journal
- Feb. 2014, CONGENITAL ANOMALIES, 54(1) (1), 35 - 40, English[Refereed]Scientific journal
- Elsevier Ireland Ltd, 2014, European Journal of Obstetrics Gynecology and Reproductive Biology, 177, 89 - 93, English[Refereed]Scientific journal
- Takayasu's disease is characterized by vasculitis of the aorta and its main branches. The disease often affects the outcome of pregnancy. We report four cases of pregnancy complicated with Takayasu's disease. All four were diagnosed as Takayasu's disease, and allowed to get pregnant before pregnancy. Two had undergone surgery for affected vessels and/or cardiac valves before their pregnancies; one had vascular graft for the ascending aortic arch for the dilation of ascending aorta, aortic valve replacement for the AR IV°, and vascular graft for the abdominal aorta for the dilation of abdominal aorta. The other one had aortic valve replacement for AR IV° and aortic left subclavian artery bypass grafting for the stenosis of the left subclavian artery. All four received prednisolone treatment. Three of the pregnancies ended in vaginal deliveries with epidural analgesia. One resulted in an elected cesarean section because of disease deterioration. The mothers and babies experienced uneventful puerperal periods. To assess the state of disease before pregnancy and careful management of medication during pregnancy and delivery is very important. [Adv Obstet Gynecol, 65 (4) : 408-413, 2013(H25.11)]THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, Nov. 2013, 産婦人科の進歩, 65(4号) (4号), 408 - 413, Japanese[Refereed]Scientific journal
- Nov. 2013, Reproductive Immunology and Biology, 28(1-2) (1-2), 93, Japanese不育症および自己免疫疾患における抗リン脂質抗体陽性患者の妊娠帰結(Pregnancy outcome in antiphospholipid antibody positive patients of infertility and autoimmune disease)(英語)Research society
- Nov. 2013, Reproductive Immunology and Biology, 28(1-2) (1-2), 93, Japanese抗リン脂質抗体症候群(APS)に対する大量免疫グロブリン療法の現状(A trial of high dose intravenous immunoglobulin therapy for pregnant women with anti-phospholipid syndrome (APS))(英語)Research society
- We report a monochorionic diamniotic twin pair born at 29 weeks of gestation in which both twins developed severe retinopathy of prematurity (ROP) with retinal detachment. The pregnancy was terminated due to reversal of donor-recipient phenotypes in possible TTTS. Both twins had unstable cardiopulmonary status during the first week, and developed chronic lung disease. The larger twin, born at 1372 g, developed stage 4a ROP in both eyes, and the smaller twin, born at 1168 g, developed stage 4a ROP in the left eye. Genetic analysis of NDP, FZD4, LRP5, TSPAN12 genes revealed no mutations; however, VEGF gene polymorphism analysis showed heterozygous carrier state of the VEGF 936T allele in both twins, which is a risk factor for threshold ROP in Japanese newborn infants. We speculate the synergistic effects of unstable perinatal cardiopulmonary status and genetic predisposition due to VEGF 936C>T polymorphism caused the development of severe ROP with retinal detachment.Jun. 2013, Pediatrics international : official journal of the Japan Pediatric Society, 55(3) (3), 366 - 8, English, International magazine[Refereed]Scientific journal
- Lead, May 2013, JOURNAL OF MEDICAL VIROLOGY, 85(5) (5), 935 - 938, English[Refereed]Scientific journal
- Dec. 2012, 日本周産期・新生児医学会雑誌, 48(4号) (4号), 976 - 980, Japanese妊娠中に喀血をきたした右肺動脈欠損症合併妊娠の1例[Refereed]Scientific journal
- Dec. 2012, JOURNAL OF MEDICAL VIROLOGY, 84(12) (12), 1928 - 1933, English[Refereed]Scientific journal
- Sep. 2012, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 95(1-2) (1-2), 73 - 79, English[Refereed]Scientific journal
- (一社)日本周産期・新生児医学会, Sep. 2012, 周産期学シンポジウム, (30) (30), 53 - 59, Japanese長期予後からみた出生前診断症例における周産期管理の再評価 長期予後からみた出生前診断と治療 母体及び胎盤・臍帯要因で極低出生体重児として出生した重度胎児発育不全児の3歳時の精神運動発達[Refereed]Scientific journal
- May 2012, 日本周産期・新生児医学会雑誌, 48(1号) (1号), 121 - 126, Japanese治療に難渋したループス腎炎合併妊娠の1例[Refereed]Scientific journal
- Lead, Apr. 2012, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 38(4) (4), 749 - 752, English[Refereed]Scientific journal
- Changes in maternal lifestyle are likely to influence the morbidity in pregnancies complicated with gestational diabetes mellitus (GDM) and diabetes mellitus (DM). We retrospectively assessed pregnancy outcomes among women with type-1 and type-2 DM (n=65) and GDM (n=65) who gave births during the period between January 2005 and September 2010. The GDM group comprised 25 GDM women who satisfied the new GDM diagnostic criteria and 40 GDM women who satisfied the old GDM diagnostic criteria. Pregnant women who satisfied the new GDM diagnostic criteria but not the old GDM diagnostic criteria were designated as new GDM women in this study. Results showed that type-1 DM women had higher levels of glycated hemoglobin (HbA1c) and glycoalbumin (GA) than the other women. Moreover, type-1 DM women had significantly higher frequencies of delivering infants who were heavy for date (HFD) or had shoulder dystocia than the other women. Type 2 DM women had significantly higher frequencies of obesity and hypertension than the other women. Three new GDM women showed high insulin resistance (homeostasis model assessment ratio [HOMA-R] ≥ 2.5), and received diet therapy and insulin injections. Type-1 DM women had high risks of adverse pregnancy outcomes because of hyperglycemia that could not be well controlled in these women. [Adv Obstet Gynecol, 64 (1) : 9-16, 2012 (H24.2)]THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, Feb. 2012, 産婦人科の進歩, 64(1号) (1号), 9 - 16, Japanese[Refereed]Scientific journal
- Lead, 2012, In TecThe management of antiphospholipid antibodies affected pregnancy.[Refereed][Invited]In book
- Chronic hypertension is a major medical complication during pregnancy that may result in poor perinatal outcome. Most cases with jeopardized offspring are considered to have preeclampsia superimposed on a preexisting hypertensive state. In Japan, during gestation, worsening of hypertension without proteinuria is not categorized as superimposed preeclampsia. However, pregnancies complicated by worsened hypertension may have poor perinatal outcomes like those with superimposed preeclampsia. This study aimed to clarify the differences between these 2 conditions with regard to perinatal outcomes. The study subjects included 42 pregnant women with chronic hypertension. Retrospective analyses were perfomed using medical records and the subjects were classified into the following 3 groups. The mild hypertension group (n=22), in which patients remained mildly hypertensive throughout pregnancy; the severe hypertension group (n=9), in which patients become severely hypertensive after 20 weeks of gestation; and the superimposed preeclampsia group (n=11). Clinical parameters of the patients were compared among the groups. In this study, poor perinatal outcomes were defined as intrauterine fetal death, neonatal death, birth weight less than 1500 g, growth restriction less than -2.0 SD, or severe neonatal asphyxia with an Apgar score of 3 or less. No statistical differences were observed for maternal age, pregestational BMI (body mass index) and BMI just before delivery among the groups. However, in cases with poor perinatal outcomes, the rate at which antihypertensive medication was used during the early half of gestation was higher than in cases without poor perinatal outcomes (88% vs. 32%, p=0.015), although this rate was not associated with the final state of the mothers. In the severe hypertension group, gestational age at delivery was significantly earlier than that in the mild hypertension group. The rates of both cesarean section and poor perinatal outcomes were significantly higher in the former than that in the latter groups. However, no statistical differences were observed in these parameters between the severe hypertension and the superimposed preeclampsia groups. This study suggests that antihypertensive therapy during the first half of gestation may be a predictive factor of poor perinatal outcomes. Furthermore, we suggest that the worsening of hypertension without development of proteinuria during pregnancy and superimposed preeclampsia may be a warning state of poor perinatal outcomes. [Adv Obstet Gynecol, 64(1) : 17-22, 2012 (H24.2)]THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, 2012, ADVANCES IN OBSTETRICS AND GYNECOLOGY, 64(1) (1), 17 - 22, Japanese
- 2012, ISRN Obstet Gynecol, 2012, 512732, EnglishA high dose intravenous immunoglobulin therapy for women with four or more recurrent spontaneous abortions[Refereed]Scientific journal
- Jan. 2012, 日本妊娠高血圧学会雑誌, 19, 156 - 158, Japanese妊娠28週以下の人工早産におけるPIH症例の検討Symposium
- 4, Oct. 2011, Journal of prenatal medicine, 5, 93 - 96Resection of giant liver hemangioma in a pregnant woman with coagulopathy: Case report and literature review.[Refereed]
- Jun. 2011, 日本周産期・新生児医学会雑誌, 47(2号) (2号), 518, Japanese周産期大量出血に対するinterventional radiology[Refereed]Scientific journal
- Jun. 2011, 日本周産期・新生児医学会雑誌, 47(2号) (2号), 444, Japanese糖尿病合併妊娠56例および妊娠糖尿病72例の周産期帰結に関する検討[Refereed]Scientific journal
- May 2011, 産婦人科の進歩, 63(2号) (2号), 260, Japanese高安病合併妊娠の3症例[Refereed]Scientific journal
- May 2011, 産婦人科の進歩, 63(2号) (2号), 251, JapaneseLong VA typeの発作性上室性頻拍(PSVT)に対し、母体ソタロール投与が有効であった一例[Refereed]Scientific journal
- May 2011, 産婦人科の進歩, 63(2号) (2号), 246, Japanese出生後に新生児の染色体検査を施行した症例の検討[Refereed]Scientific journal
- May 2011, 産婦人科の進歩, 63(2号) (2号), 260, Japanese妊娠中肺出血を起こした右肺動脈欠損症合併妊娠の1症例[Refereed]Scientific journal
- Feb. 2011, 日本産科婦人科学会雑誌, 63(2号) (2号), 504, Japanese男性化および低リン血症をきたした卵巣腫瘍の1例[Refereed]Scientific journal
- 日本産科婦人科学会, Feb. 2011, 日本産科婦人科学会雑誌, 63(2号) (2号), 569 - 569, Japanese糖尿病合併妊娠および妊娠糖尿病の周産期予後[Refereed]Scientific journal
- 日本産科婦人科学会, Feb. 2011, 日本産科婦人科学会雑誌, 63(2号) (2号), 624 - 624, Japanese切迫早産、前期破水(PROM)から28週以下で早産に至った症例の検討[Refereed]Scientific journal
- 日本産科婦人科学会, Feb. 2011, 日本産科婦人科学会雑誌, 63(2号) (2号), 634 - 634, JapaneseLong VA typeの発作性上室性頻拍(PSVT)に対し、母体ソタロール投与が有効であった一例[Refereed]Scientific journal
- Feb. 2011, 日本産科婦人科学会雑誌, 63(2号) (2号), 733, Japanese先天性サイトメガロウイルス感染症の5症例[Refereed]Scientific journal
- 日本産科婦人科学会, Feb. 2011, 日本産科婦人科学会雑誌, 63(2号) (2号), 782 - 782, Japanese周産期大量出血に対するinterventional radiology[Refereed]Scientific journal
- THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, 2011, ADVANCES IN OBSTETRICS AND GYNECOLOGY, 63(3) (3), 423 - 425, Japanese
- Dec. 2010, 日本妊娠高血圧学会雑誌, 18, 187 - 188, Japanese早発型重症妊娠高血圧腎症で術後にHELLP症候群・産科的DIC・肺水腫・肝梗塞を発症した一例[Refereed]Scientific journal
- Dec. 2010, 日本妊娠高血圧学会雑誌, 18, 171 - 172, Japanese当院における高血圧合併妊娠35症例の周産期予後に関する後方視的検討[Refereed]Scientific journal
- Dec. 2010, 日本妊娠高血圧学会雑誌, 18, 105 - 108, JapaneseSLE合併妊娠の転帰、産科異常とPIH[Refereed]Scientific journal
- THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, 2010, ADVANCES IN OBSTETRICS AND GYNECOLOGY, 62(2) (2), 73 - 75, Japanese
- THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, 2008, ADVANCES IN OBSTETRICS AND GYNECOLOGY, 60(3) (3), 292 - 294, Japanese
- Jan. 2006, Gynecological Endocrinology, 22(1) (1), 48 - 53, English[Refereed]Scientific journal
- Lead, Jul. 2004, European Journal of Endocrinology, 151(1) (1), 93 - 101, English[Refereed]Scientific journal
- 2021, 日本女性栄養・代謝学会誌, 27(1) (1)母子感染の話題~新型コロナウイルス,梅毒,トキソプラズマ,サイトメガロウイルス
- 2021, 日本周産期・新生児医学会雑誌(Web), 57(Suppl) (Suppl)胎児治療と新生児治療の併用は先天性サイトメガロウイルス感染症児の予後を改善する
- 2021, 日本周産期・新生児医学会雑誌(Web), 57(Suppl) (Suppl)非初感染母体から出生した重篤な症候性先天性サイトメガロウイルス感染症児の一例
- 2021, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 37th不育症と子宮内膜マイクロバイオームとの関連
- Jan. 2021, PLACENTA, 103, 253 - 254, EnglishA NOVEL AUTOANTIBODY AGAINST beta 2-GLYCOPROTEIN I/HLA CLASS II COMPLEXES IS A MAJOR RISK FACTOR FOR RECURRENT PREGNANCY LOSSSummary international conference
- AIM: To evaluate pregnancy outcome and complications in subsequent pregnancies after severe post-partum hemorrhage (PPH) between women with and without a history of uterine artery embolization (UAE). METHODS: Women who had a history of severe PPH, and delivered newborns at ≥22 gestational weeks in subsequent pregnancies were enrolled. Severe PPH was defined as blood loss volume of more than 2000 mL. RESULTS: The blood loss volume (median 1581 mL) in women with UAE (n = 14) was significantly more than that in women without UAE (median 1021 mL, n = 32, P < 0.01), and the recurrence rate of severe PPH in women with UAE (n = 5, 35.7%) was significantly higher than that in women without UAE (n = 3, 9.4%, P < 0.05). There were no significant differences in frequencies of premature delivery, hypertensive disorders of pregnancy, fetal growth restriction, or placenta previa/low lying placenta. Of 14 women with UAE, 7 (50.0%) had abnormally invasive placenta, whereas of 32 women without UAE, none had abnormally invasive placenta. CONCLUSION: Subsequent pregnancies after UAE for severe PPH had high risks for recurrence of severe PPH.Jan. 2020, The journal of obstetrics and gynaecology research, 46(1) (1), 119 - 123, English, International magazine[Refereed]
- (株)東京医学社, Jan. 2020, 小児内科, 52(1) (1), 23 - 29, Japanese【母子感染症の必修知識-エキスパートに学び予防につなげる】総論 母子感染スクリーニング方法と診断の話題
- Sep. 2019, LUPUS, 28, 54 - 54, EnglishAutoantibody against beta2-glycoprotein I/HLA class II complex as a risk factor for recurrent pregnancy lossSummary international conference
- Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2018 there were nine themed workshops, five of which are summarised in this report. These workshops discussed new perspectives and knowledge in the following areas of research: 1) preeclampsia; 2) abnormally invasive placenta; 3) placental infection; 4) gestational trophoblastic disease; 4) drug delivery to treat placental dysfunction.01 Sep. 2019, Placenta, 84, 9 - 13, English, International magazine
- 「産婦人科の進歩」編集室, May 2019, 産婦人科の進歩, 71(2) (2), 103 - 108, Japanese妊娠中に維持透析療法を要した慢性腎不全合併妊娠3症例[Refereed]
- Human cytomegalovirus (CMV) is a common cause of congenital infection that may lead to severe long-term sequelae. Because there are no established vaccines, fetal interventions or neonatal treatments, neither maternal nor neonatal screening is recommended. However, recent studies have indicated that early antiviral treatment may improve neurological outcomes in symptomatic infants with congenital infection. Therefore, prenatal detection may be important in newborns at high risk of such infection. Polymerase chain reaction for CMV DNA in the amniotic fluid is considered the gold standard for diagnosis of intrauterine infection, but its use is limited because amniocentesis is an invasive procedure. In a prospective cohort study, we have reported that the presence of CMV DNA in secretions of the maternal uterine cervix were predictive of congenital infection in groups at high risk. However, we also recently demonstrated that maternal serological screening for primary CMV infection using specific immunoglobulin G, the immunoglobulin G avidity index or specific immunoglobulin M can overlook many cases. Previous research has indicated that the combination of early detection by universal neonatal screening of urinary CMV DNA combined with early antiviral therapy can improve outcomes in infants with symptomatic congenital infection. In this article, we review the current state of maternal and neonatal screening for congenital CMV infection.Mar. 2019, J Obstet Gynaecol Res, 45(3) (3), 514 - 521, English, International magazine[Refereed]
- (一社)日本周産期・新生児医学会, Jan. 2019, 日本周産期・新生児医学会雑誌, 54(別冊) (別冊), 26 - 27, Japanese症候性先天性サイトメガロウイルス感染症に対する胎児治療と新生児治療
- (株)メディカ出版, Jan. 2019, ペリネイタルケア, (2019新春増刊) (2019新春増刊), 196 - 205, Japanese【周産期のくすり大事典 妊娠期・分娩時・産褥期・新生児の薬剤＆ワクチン133大解説】(第2部)くすりカタログ(第1章)妊娠期のくすり 感染症 トキソプラズマ[Invited]Introduction scientific journal
- Jan. 2019, ペリネイタルケア, (2019新春増刊) (2019新春増刊), 95 - 97, Japanese【周産期のくすり大事典 妊娠期・分娩時・産褥期・新生児の薬剤＆ワクチン133大解説】(第1部)くすり大解説(第2章)妊娠期のくすり 先天性サイトメガロウイルス感染の予防と胎児治療[Invited]Introduction commerce magazine
- Jan. 2019, ペリネイタルケア, (2019新春増刊) (2019新春増刊), 76 - 77, Japanese【周産期のくすり大事典 妊娠期・分娩時・産褥期・新生児の薬剤＆ワクチン133大解説】(第1部)くすり大解説(第2章)妊娠期のくすり 感染症 トキソプラズマIntroduction commerce magazine
- Nov. 2018, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 130, 32 - 32, EnglishSummary international conference
- 日本生殖免疫学会, Nov. 2018, Reproductive Immunology and Biology, 33(1-2) (1-2), 93 - 93, Japanese不育症リスク因子としてのネオ・セルフ抗体
- Nov. 2018, 週刊日本医事新報, 4934, 56, Japanese臨床各科差分解説 [産科]抗SSA抗体陽性妊婦の管理：先天性完全房室ブロックの予防法や胎児治療法は？[Invited]Introduction commerce magazine
- Early diagnosis and treatment of infants with symptomatic congenital cytomegalovirus (CMV) infection may improve neurological outcomes. For this reason, prenatal detection of newborns at high risk for congenital CMV infection is important. A polymerase chain reaction (PCR) assay for CMV DNA in the amniotic fluid is the gold standard for the diagnosis of intrauterine CMV infection; however, amniocentesis is an invasive procedure. Recently, we have found that the presence of CMV DNA in the maternal uterine cervical secretion is predictive of the occurrence of congenital CMV infection in CMV immunoglobulin M (IgM)-positive pregnant women. In contrast, we have suggested that maternal serological screening for primary CMV infection using CMV-specific immunoglobulin G (IgG), the IgG avidity index, or CMV-specific IgM overlooks a number of newborns with congenital CMV infection. We will review current knowledge of the potential biomarkers for predicting congenital CMV infection.Nov. 2018, Int J Mol Sci, 19(12) (12), English, International magazine[Refereed]
- Oct. 2018, 週刊日本医事新報, 4931, 54, Japanese臨床各科差分解説 [産科]潜在性甲状腺機能低下症を有する不妊症女性の管理：検査ならびに治療の意義と必要性は？[Invited]Introduction commerce magazine
- (一社)日本生殖医学会, Aug. 2018, 日本生殖医学会雑誌, 63(3) (3), 230 - 230, Japanese不育症のトピックス 不育症とネオ・セルフ
- Jul. 2018, 産科と婦人科, 85(7号) (7号), 812 - 816, Japanese【産婦人科関連ホルモンの基礎を学びなおす】 TRH、TSH、甲状腺ホルモンとその受容体[Invited]Introduction scientific journal
- May 2018, 産婦人科の進歩, 70(2) (2), 168 - 172, Japanese前置癒着胎盤の術前診断と管理法についてIntroduction scientific journal
- 2018, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging, 19th胎児臍帯ヘルニア破裂の一例
- 2018, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 35thトキソプラズマ抗体妊婦スクリーニングに関する前向きコホート研究
- (一社)日本産婦人科感染症学会, 2018, 日本産婦人科感染症学会誌, 2(1) (1), 2 - 12, Japaneseサイトメガロウイルス母子感染の対策Introduction scientific journal
- 2018, INTECH OPEN PLACENTA, 9(1) (1), 85 - 94, EnglishManagement of Placenta Accreta in Pregnancy with Placenta Previa[Refereed]Introduction scientific journal
- Jan. 2018, 週刊日本医事新報, 4892, 54, Japanese臨床各科差分解説 [産科]前置癒着胎盤の管理：適切な術前準備と術式は？[Invited]Introduction commerce magazine
- Jan. 2018, 臨床婦人科産科, 72(1号) (1号), 64 - 70, Japanese【産婦人科感染症の診断・管理-その秘訣とピットフォール】母子感染症 サイトメガロウイルスIntroduction scientific journal
- Nov. 2017, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 124, 76 - 76, EnglishSummary international conference
- Nov. 2017, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 124, 80 - 81, EnglishSummary international conference
- Nov. 2017, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 124, 80 - 80, EnglishSummary international conference
- Nov. 2017, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 124, 81 - 81, EnglishSummary international conference
- 診断と治療社, Nov. 2017, チャイルド ヘルス, 20(11号) (11号), 833 - 836, Japanese【身近なペットからうつる子どもの感染症～ズーノーシスを予防するために～】 トキソプラズマ症Introduction commerce magazine
- 金原出版, Oct. 2017, 産婦人科の実際, 66(10号) (10号), 1255 - 1261, Japanese【産婦人科診療で用いられるバイオマーカー】 母子感染症のマーカー(avidity index)Introduction commerce magazine
- Sep. 2017, 日本甲状腺学会雑誌, 8(2号) (2号), 85 - 99, Japanese【甲状腺ホルモンと関連疾患】 甲状腺ホルモンと妊娠/不妊症/不育症 不妊症Introduction scientific journal
- Sep. 2017, 日本医事新報, (4872号) (4872号), 40 - 47, Japanese【TORCH症候群-母子感染における問題点】 先天性トキソプラズマ症の予防、診断と治療[Invited]Introduction commerce magazine
- Sep. 2017, 日本医事新報, (4872号) (4872号), 33 - 39, Japanese【TORCH症候群-母子感染における問題点】 先天性サイトメガロウイルス感染症の予防、診断と治療[Invited]Introduction commerce magazine
- 診断と治療社, Jul. 2017, 産科と婦人科, 84(7号) (7号), 804 - 809, Japanese【産婦人科領域における難病を考える-新たに成立した難病法の視点から】 [指定難病疾患] 抗リン脂質抗体症候群[Invited]Introduction commerce magazine
- May 2017, JOURNAL OF IMMUNOLOGY, 198(1) (1), EnglishCellular misfolded proteins transported to the cell surface by aberrantly expressed MHC class II molecules are major autoantibody targets in autoimmune diseasesSummary international conference
- May 2017, CLINICAL INFECTIOUS DISEASES, 64(10) (10), 1469 - 1469, EnglishOthers
- 東京医学社, Feb. 2017, 周産期医学, 47(2) (2), 213 - 218, Japaneseサイトメガロウイルス (特集 周産期のウイルス感染症) -- (妊娠・分娩・産褥時の対応)
- (公社)日本産科婦人科学会, Feb. 2017, 日本産科婦人科学会雑誌, 69(2号) (2号), 1024 - 1024, Japanese胎児腹水を呈した症候性先天性サイトメガロウイルス感染症3例の出生後の臨床経過Meeting report
- 2017, 母性衛生, 58(3) (3)サイトメガロウイルス感染に対する妊婦抗体スクリーニング
- 2017, Reproductive Immunology and Biology, 32(1-2) (1-2)トキソプラズマ妊婦スクリーニングの前向きコホート研究
- 2017, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 34thトキソプラズマ妊婦スクリーニングの前向き研究
- 2017, 産婦人科の進歩, 69(2) (2), 169 - 170, Japanese妊婦が水痘患者と濃厚接触、もしくは水痘を発症した場合の対応について[Invited]Introduction commerce magazine
- 2017, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 17(6) (6), 535 - 537, English, International magazine[Refereed]
- Dec. 2016, 周産期医学, 46(増刊) (増刊), 114 - 117, Japanese【周産期医学必修知識第8版】 産科編 抗リン脂質抗体検査[Invited]Introduction commerce magazine
- Dec. 2016, 周産期医学, 46(増刊) (増刊), 120 - 123, Japanese【周産期医学必修知識第8版】 産科編 トキソプラズマ[Invited]Introduction commerce magazine
- 金原出版, Dec. 2016, 産婦人科の実際, 65(13号) (13号), 1719 - 1724, Japanese【産婦人科感染症の最前線】 母子に影響を与える感染症 トキソプラズマ感染症[Invited]Introduction commerce magazine
- Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 117 - 117, EnglishSummary international conference
- Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 119 - 119, EnglishSummary international conference
- Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 145 - 146, EnglishSummary international conference
- Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 116 - 116, EnglishSummary international conference
- Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 131 - 132, EnglishSummary international conference
- Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 120 - 120, EnglishSummary international conference
- Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 113 - 113, EnglishSummary international conference
- Nov. 2016, Reproductive Immunology and Biology, 31(1-2号) (1-2号), 87, Japanese抗リン脂質抗体の新たな展開 抗β2-glycoproteinI/HLA class II複合体抗体測定を用いた新しい抗リン脂質抗体症候群診断の可能性[Invited]Meeting report
- Oct. 2016, PLACENTA, 46, 108 - 108, EnglishA NOVEL AUTOANTIBODY IS ASSOCIATED WITH RECURRENT MISCARRIAGESummary international conference
- Oct. 2016, PLACENTA, 46, 108 - 108, EnglishPREDICTION OF ADHERENT PLACENTA WITH PLACENTA PREVIA USING A NOVEL SCORING SYSTEMSummary international conference
- Sep. 2016, 母性衛生, 57(3号) (3号), 217, Japanese帝王切開後の子宮筋層壊死により子宮全摘出術を余儀なくされた3例
- Sep. 2016, 母性衛生, 57(3号) (3号), 270, JapaneseIgG avidityとPCR法を用いたサイトメガロウイルス妊娠スクリーニング
- Sep. 2016, 母性衛生, 57(3号) (3号), 191, Japanese妊娠初期にパルボウイルスB19に感染した4例[Refereed]Meeting report
- 診断と治療社, Sep. 2016, 産科と婦人科, 83(9号) (9号), 1065 - 1070, Japanese【妊娠と感染症-外来で聞かれてどう説明する?】 トキソプラズマIntroduction commerce magazine
- Aug. 2016, EUROPEAN JOURNAL OF IMMUNOLOGY, 46, 27 - 27, EnglishCellular misfolded proteins rescued from degradation by MHC class II molecules are targets for autoantibodies in autoimmune diseasesSummary international conference
- Jun. 2016, 日本周産期・新生児医学会雑誌, 52(2号) (2号), 413, Japanese母子感染対策の最前線2016年 本邦におけるパルボウイルスB19母子感染の実態
- Jun. 2016, 日本周産期・新生児医学会雑誌, 52(2号) (2号), 736, Japanese胎児甲状腺機能亢進症を来たしたT3優位型バセドウ病合併妊娠の1例
- Jun. 2016, 日本周産期・新生児医学会雑誌, 52(2号) (2号), 673, Japanese先天性アンチトロンビン(AT)欠乏症合併妊娠の管理方針 21症例の経験より
- Jun. 2016, 日本周産期・新生児医学会雑誌, 52(2号) (2号), 678, Japanese新生児同種免疫性血小板減少症の3例
- Jun. 2016, 日本周産期・新生児医学会雑誌, 52(2号) (2号), 735, Japanese抗リン脂質抗体症候群合併妊娠に対する免疫グロブリン療法[Refereed]Meeting report
- Jun. 2016, ペリネイタルケア, (2016夏季増刊) (2016夏季増刊), 224 - 228, Japanese【正常の確認と異常への対応を究める! 妊婦健診と保健指導パーフェクトブック 妊娠期別ガイド】(第2部)ハイリスク妊娠編 甲状腺疾患合併妊娠[Invited]Introduction commerce magazine
- May 2016, 産婦人科の進歩, 68(2号) (2号), 175, Japanese胎児甲状腺機能亢進症を来たしたTRAb著明高値バセドウ病合併妊娠の1例
- May 2016, 産婦人科の進歩, 68(2号) (2号), 201, Japanese子宮筋層壊死により子宮全摘出術を余儀なくされた3例
- May 2016, 産婦人科の進歩, 68(2号) (2号), 196, JapaneseIgG avidityとPCR法を用いたサイトメガロウイルス妊婦スクリーニング
- Feb. 2016, 日本産科婦人科学会雑誌, 68(2号) (2号), 781, Japanese妊娠初期にパルボウイルスB19に感染した4例[Refereed]
- Feb. 2016, 日本産科婦人科学会雑誌, 68(2号) (2号), 983, Japanese帝王切開術後にMycoplasma hominis腹膜炎を発症した3例[Refereed]
- Feb. 2016, 日本産科婦人科学会雑誌, 68(2号) (2号), 781, Japanese先天性サイトメガロウイルス感染症児における生後早期の頭部MRI所見
- 日本産科婦人科学会, Feb. 2016, 日本産科婦人科学会雑誌, 68(2号) (2号), 950 - 950, Japanese新生児同種免疫性血小板減少症の2例 過去の妊娠で児が新生児同種免疫性血小板減少症を発症した女性の周産期管理
- Feb. 2016, 日本産科婦人科学会雑誌, 68(2号) (2号), 744, Japanese子宮動脈塞栓術後に保存的治療抵抗性の子宮内膜筋層炎を発症し子宮摘出に至った2例
- 科学評論社, Feb. 2016, 臨床免疫・アレルギー科, 65(2号) (2号), 112 - 118, Japanese【全身性免疫疾患の機序の解明】 β2-グリコプロテインI/HLA class II複合体は抗リン脂質抗体症候群の標的抗原である[Invited]Introduction commerce magazine
- 日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 577 - 577, EnglishISP-34-5 Protein S deficiency complicated pregnancy in women with recurrent pregnancy loss(Group 34 Infertility/Recurrent Pregnancy Loss,International Session Poster) :
- 日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 555 - 555, EnglishISP-27-1 Pregnancy after uterine artery embolization for the treatment of post-partum hemorrhage : a case series(Group 27 Maternal Complication 3,International Session Poster) :
- 日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 554 - 554, EnglishISP-26-6 To assess the management of pregnancies complicated with antithrombin deficiency : A report of 20 cases(Group 26 Maternal Complication 2,International Session Poster) :
- 日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 545 - 545, EnglishISP-23-3 Maternal blood screening for congenital cytomegalovirus infection of the infants(Group 23 Maternal Complication 1,International Session Poster) :
- 日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 550 - 550, EnglishISP-25-5 Postpartum screening for glucose intolerance in women with gestational diabetes mellitus(Group 25 Nutrition and Metabolism,International Session Poster) :
- 日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 544 - 544, EnglishISP-23-2 The effect of maternal screening for HBV and perinatal HBV prevention program(Group 23 Maternal Complication 1,International Session Poster) :
- 日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 781 - 781, JapaneseP2-55-5 妊娠初期にパルボウイルスB19に感染した4例(Group55 周産期の感染症1,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)
- 日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 474 - 474, EnglishIS-MW-5-2 Prediction of adherent placenta with placenta previa using a novel scoring system(Group 5 Perinatology 2,International Session Mini Workshop) :
- Nov. 2015, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 112, 123 - 123, EnglishSummary international conference
- Nov. 2015, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 112, 137 - 137, EnglishSummary international conference
- Nov. 2015, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 112, 135 - 135, EnglishSummary international conference
- Oct. 2015, PLACENTA, 36(10) (10), A5 - A6, EnglishPREDICTION OF ADHERENT PLACENTA IN PATIENTS WITH PLACENTA PREVIA USING ULTRASONOGRAPHY AND MAGNETIC RESONANCE IMAGINGSummary international conference
- 医歯薬出版, 27 Jun. 2015, 医学のあゆみ, 253(13) (13), 1227 - 1231, JapaneseToxoplasma
- メディカ出版, Jun. 2015, ペリネイタルケア, 34(6) (6), 599 - 605, Japanese甲状腺疾患合併妊娠 (特集 病態生理・保健指導・分娩管理 事例で学ぶハイリスク妊娠3ステップ)
- (一社)日本周産期・新生児医学会, Jun. 2015, 日本周産期・新生児医学会雑誌, 51(2) (2), 663 - 663, Japanese
- (一社)日本産婦人科感染症学会, May 2015, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 32回, 37 - 37, Japanese新生児尿スクリーニングと抗ウイルス薬治療導入後の症候性先天性サイトメガロウイルス感染児の後遺症発生率
- (一社)日本産婦人科感染症学会, May 2015, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 32回, 38 - 38, Japanese症候性先天性サイトメガロウイルス感染児の聴性脳幹反応に対する抗ウイルス薬治療の効果と問題点
- (株)メディカルレビュー社, Apr. 2015, Fetal & Neonatal Medicine, 7(1号) (1号), 30 - 33, JapaneseIntroduction scientific journal
- メディカルレビュー社, Apr. 2015, Fetal & Neonatal Medicine, 7(1) (1), 26 - 29, Japaneseサイトメガロウイルスの治療 先天性サイトメガロウイルス感染の予防と胎児治療[Invited]Introduction commerce magazine
- (公社)日本産科婦人科学会, Feb. 2015, 日本産科婦人科学会雑誌, 67(2) (2), 601 - 601, Japanese
- 日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 933 - 933, JapaneseP3-43-7 中期流死産歴を有する抗リン脂質抗体症候群合併妊娠に対する治療効果(Group145 合併症妊娠8,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 725 - 725, JapaneseP2-30-3 血漿プロテインS低値の女性に対する遺伝子診断と妊娠時の治療法選択(Group 71 不育症 臨床,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 806 - 806, JapaneseP2-58-3 18番染色体短腕欠損が原因と考えられた全前脳胞症の1症例(Group 99 胎児異常1,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 811 - 811, JapaneseP2-59-7 抗SS-A抗体陽性妊婦の胎児大動脈-上大静脈房室伝導時間スクリーニングと先天性完全房室ブロックの発症予防(Group 100 胎児異常2,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 967 - 967, JapaneseP3-54-8 切迫早産入院管理の結果,妊娠29週未満で早産となった児の予後解析(Group 156 早産6,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 602 - 602, JapaneseP1-27-5 免疫グロブリンを用いたサイトメガロウイルス胎児感染予防と胎児治療(Group27 感染症1,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 613 - 613, JapaneseP1-31-1 Marfan症候群合併妊娠の3例(Group31 合併症妊娠2,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 631 - 631, JapaneseP1-36-8 巨大胎盤内血腫, Breus' moleの2例(Group36 胎盤2,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 1042 - 1042, EnglishISP-15-1 A rapid increase of serum IgG avidity index in women with congenital cytomegalovirus infection(Group 15 Perinatology 5,IS Poster,International Session) :
- 日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 512 - 512, JapaneseNW-9-1 先天性トキソプラズマ感染の出生前予測に有用なトキソプラズマIgG avidity index cut-off値(ミニワークショップ9 周産期ウイルス感染,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 512 - 512, JapaneseNW-9-2 サイトメガロウイルスIgM陽性妊婦における先天性感染発生の予知因子(ミニワークショップ9 周産期ウイルス感染,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- Jan. 2015, 日本周産期・新生児医学会雑誌, 50(別冊) (別冊), 22 - 23, Japanese周産期の炎症・感染への挑戦 先天性サイトメガロウイルス感染の効果的な周産期管理法の確立を目指してMeeting report
- Dec. 2014, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 106, 8 - 8, EnglishSummary international conference
- Oct. 2014, 糖尿病と妊娠, 14(2号) (2号), S - 88, Japanese受容体以後のシグナル伝達障害によるインスリン抵抗性を合併し、妊娠中もメトホルミン投与を要した一例Meeting report
- Oct. 2014, 産婦人科の進歩, 66(4号) (4号), 492, Japanese治療抵抗性の抗リン脂質抗体症候群合併妊娠に対する大量免疫グロブリン療法
- Oct. 2014, 産婦人科の進歩, 66(4号) (4号), 491, JapaneseプロテインS低下女性に対する遺伝子検査の現状
- Oct. 2014, 産婦人科の進歩, 66(4号) (4号), 485, Japanese免疫グロブリン投与によるサイトメガロウイルス母子感染予防の試みMeeting report
- Oct. 2014, 第37回日本産婦人科手術学会, 13, Japanese内腸骨動脈閉鎖バルーンカテーテルを用いた前置癒着胎盤に対する帝王切開術Meeting report
- Oct. 2014, 産婦人科の進歩, 66(4号) (4号), 484, Japanese先天性トキソプラズマ感染症の出生前予測に有用なトキソプラズマIgG avidity index cut-off値Meeting report
- Oct. 2014, 産婦人科の進歩, 66(4号) (4号), 485, Japanese症候性先天性サイトメガロウイルス感染に対する免疫グロブリンを用いた胎児治療Meeting report
- (公社)日本医学放射線学会, Sep. 2014, 日本医学放射線学会秋季臨床大会抄録集, 50回(50回) (50回), S674 - S674, English侵襲性の前置胎盤 MR imaging scoring systemによる予備的検証(Invasive placenta previa: preliminary validation of an MR imaging scoring system)Meeting report
- 東京医学社, Sep. 2014, 周産期医学, 44(9号) (9号), 1213 - 1218, Japanese【重篤な疾患を合併する妊産婦の管理】 血液疾患 特発性血小板減少性紫斑病(Idiopathic thrombocytopenic purpura)Introduction scientific journal
- Sep. 2014, 日本内分泌学会雑誌, 90(2号) (2号), 512, Japaneseバセドウ病合併妊娠における産科異常と新生児甲状腺機能異常発症の危険因子の検討Meeting report
- Prophylactic intravenous immunoglobulin injections to mothers with primary cytomegalovirus infection.The aim of this trial study was to assess the preventive efficacy of immunoglobulin with a high titer of anti-CMV antibody for mother-to-fetus cytomegalovirus (CMV) transmission among pregnant women with primary/acute CMV infection. The primary CMV infection in mothers was diagnosed by a positive test for CMV IgM and/or low IgG avidity. Intact type immunoglobulin with a high titer of anti-CMV antibody was injected intravenously at a dosage of 2.5-5.0 g/day for consecutive 3 days to mothers with primary CMV infection. Four pregnant women were enrolled. One pregnancy ended in no congenital infection, while two pregnancies ended in congenital CMV infection. The other one pregnancy was terminated. The mother-to-fetus CMV transmission rate was found to be high as 66.7% (2/3). This preliminary result suggests that intravenous immunoglobulin injections are not effective for the prevention of mother-to-fetus CMV transmission in the present protocol.11 Jul. 2014, The Kobe journal of medical sciences, 60(2) (2), E25-9, English, Domestic magazine
- Jun. 2014, ANNALS OF THE RHEUMATIC DISEASES, 73, 512 - 512, EnglishSummary international conference
- Jun. 2014, 日本周産期・新生児医学会雑誌, 50(2号) (2号), 801, Japanese胎盤トキソプラズマ感染を認めた2症例Meeting report
- Jun. 2014, 日本周産期・新生児医学会雑誌, 50(2号) (2号), 779, Japanese近年日本における母子感染の実態Meeting report
- Jun. 2014, 日本周産期・新生児医学会雑誌, 50(2号) (2号), 870, Japaneseインスリン治療を要した妊娠糖尿病妊婦の臨床像Meeting report
- Jun. 2014, 第31回日本産婦人科感染症研究会学術集会, 103, JapaneseMHCクラスIIの新しい抗原提示機能は抗リン脂質抗体症候群の病態と関連するMeeting report
- May 2014, 産婦人科の進歩, 66(2号) (2号), 250, JapaneseIgG avidityとPCR法を用いたサイトメガロウイルス妊婦スクリーニングMeeting report
- Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 587, Japanese治療抵抗性の抗リン脂質抗体症候群合併妊娠に対する大量免疫グロブリン療法
- Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 585, Japanese不育症および自己免疫疾患における抗リン脂質抗体陽性患者の妊娠帰結Meeting report
- Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 684, Japanese近年日本における母子感染の実態Meeting report
- 日本産科婦人科学会, Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 685 - 685, Japanese急速なIgG avidity index上昇はサイトメガロウイルス先天性感染の発生予知因子であるMeeting report
- Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 685, JapaneseIgG avidityとPCR法を用いたサイトメガロウイルス妊婦スクリーニングMeeting report
- 日本産科婦人科学会, Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 584 - 584, JapaneseHLAクラスII/β2-glycoprotein Iタンパク質複合体は抗リン脂質抗体症候群の病態に関わる主要な標的分子であるMeeting report
- 日本産科婦人科学会, 2014, 日本産科婦人科學會雜誌, 66(2) (2), 684 - 684, JapaneseP2-37-4 近年日本における母子感染の実態(Group 75 周産期の感染症2,一般演題,第66回学術講演会)
- 日本産科婦人科学会, 2014, 日本産科婦人科學會雜誌, 66(2) (2), 920 - 920, EnglishISAC-3-4 The IgG avidity value for the prediction of congenital cytomegalovirus infection in a prospective cohort study(Group 3 Perinatology,IS Award Candidate,International Session) :
- Oct. 2013, 日本生殖医学会雑誌, 58(4号) (4号), 250, Japanese不育症診療における新しい展開 抗リン脂質抗体陽性者の妊娠管理
- 東京医学社, Oct. 2013, 周産期医学, 43(10号) (10号), 1295 - 1299, Japanese【臨床研究の成果を実地臨床へ生かそう-産科編】 我が国における多施設共同研究の現状 サイトメガロウイルス[Invited]Introduction scientific journal
- Jun. 2013, 日本周産期・新生児医学会雑誌, 49(2号) (2号), 689, Japanese全前置胎盤における超音波・MRIを用いた癒着胎盤のリスク因子の検討
- Jun. 2013, 日本周産期・新生児医学会雑誌, 49(2号) (2号), 708, Japanese効果的な妊婦CMVスクリーニング法の確立を目指して
- 社団法人日本産科婦人科学会, Feb. 2013, 日本産科婦人科學會雜誌, 65(2) (2), 694 - 694, JapaneseK2-7-8 効果的な妊婦CMVスクリーニング法の確立を目指して(高得点演題12 周産期医学3,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)
- Feb. 2013, 日本産科婦人科学会雑誌, 65(2号) (2号), 897, Japanese免疫グロブリンを用いた先天性サイトメガロウイルス感染に対する胎児感染予防と治療
- 日本産科婦人科学会, Feb. 2013, 日本産科婦人科学会雑誌, 65(2号) (2号), 897 - 897, Japanese母体血サイトメガロウイルスIgG avidity測定による先天性感染の発生予知
- Feb. 2013, 日本産科婦人科学会雑誌, 65(2号) (2号), 937, Japanese全前置胎盤における超音波・MRIを用いた癒着胎盤のリスク因子の検討
- Feb. 2013, 日本産科婦人科学会雑誌, 65(2号) (2号), 895, Japanese全国妊婦健診施設を対象とした妊婦感染症スクリーニングと先天性感染の実態調査
- Feb. 2013, 日本産科婦人科学会雑誌, 65(2号) (2号), 898, Japanese先天性サイトメガロウイルス感染症に対するバルガンシクロビル療法の効果と副作用
- 日本産科婦人科学会, 2013, 日本産科婦人科學會雜誌, 65(2) (2), 895 - 895, JapaneseP3-15-2 母子感染に関する妊婦の知識調査(Group 120 周産期・感染症,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)
- 2013, 先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 平成23-24年度 総合研究報告書, 109, Japanese先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討,妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 神戸大学における先天性CMV感染児の臨床像とフォローアップの現況
- 2013, 先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 平成23-24年度 総合研究報告書, 31 - 53, Japanese先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討,妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 サイトメガロウイルス母子感染対策のための妊婦教育効果の検討,ならびに妊婦スクリーニング体制の構築
- 2013, 先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 平成24年度 総括・分担研究報告書, 86, Japanese先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討,妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 7.全国妊婦健診施設を対象とした妊婦感染症スクリーニングと先天性感染の実態調査
- 2013, 先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 平成23-24年度 総合研究報告書, 113, Japanese先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討,妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 CMV IgM陽性妊婦における先天性CMV感染の発生予測
- 2013, 先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 平成24年度 総括・分担研究報告書, 87, Japanese先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討,妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 8.母体血CMV IgG avidity測定による先天性感染の発生予知
- 2013, 先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 平成23-24年度 総合研究報告書, 114, Japanese先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討,妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 妊婦におけるCMV母子感染に関する知識レベル
- 2013, 先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 平成24年度 総括・分担研究報告書, 88, Japanese先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討,妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 9.先天性CMV感染に対する免疫グロブリン胎児治療
- 2013, 先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 平成24年度 総括・分担研究報告書, 85, Japanese先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討,妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 6.母子感染に関する妊婦の知識調査
- Nov. 2012, 産婦人科の進歩, 64(4号) (4号), 509 - 510, Japanese抗リン脂質抗体陽性女性の妊娠管理[Refereed][Invited]Others
- Jul. 2012, 日本生殖医学会雑誌, 57(3号) (3号), 124, Japanese抗リン脂質抗体陽性患者の治療と妊娠帰結[Refereed]
- 金原出版, Jul. 2012, 産婦人科の実際, 61(7号) (7号), 1043 - 1049, Japanese【産科外来診療フローチャート-妊婦管理のすべて-】 合併症妊娠の評価と管理 全身性エリテマトーデスと抗リン脂質抗体症候群[Refereed][Invited]Introduction scientific journal
- Jun. 2012, 日本周産期・新生児医学会雑誌, 48(2号) (2号), 409, Japanese妊婦におけるサイトメガロウイルス母子感染に関する知識レベル
- Jun. 2012, 日本周産期・新生児医学会雑誌, 48(2号) (2号), 545, Japanese妊娠中の水痘感染により子宮内胎児死亡に至った1例
- Jun. 2012, 日本周産期・新生児医学会雑誌, 48(2号) (2号), 415, Japanese全前置癒着胎盤の術前診断における問診および超音波検査所見の診断精度の検討
- Jun. 2012, 日本周産期・新生児医学会雑誌, 48(2号) (2号), 555, Japanese甲状腺機能亢進症合併妊娠の帰結と新生児甲状腺機能異常[Refereed]
- Jun. 2012, 日本周産期・新生児医学会雑誌, 48(2号) (2号), 545, JapaneseCMV IgM陽性妊婦における先天性CMV感染の発生予測[Refereed]
- Jun. 2012, 日本周産期・新生児医学会雑誌, 48(2号) (2号), 561, Japanese75gOGTTでの1点陽性と2点以上陽性の妊娠糖尿病妊婦の背景と周産期帰結[Refereed]
- May 2012, 産婦人科の進歩, 64(2号) (2号), 259, Japanese妊娠中の水痘初感染により子宮内胎児死亡に至った1例
- May 2012, 産婦人科の進歩, 64(2号) (2号), 276, Japanese産褥11日目に発症した子癇の1例
- Apr. 2012, 臨床婦人科産科, 66(5号) (5号), 166 - 174, Japanese【オフィス ギネコロジー 女性のプライマリ・ケア】 妊婦 母子感染の管理 トキソプラズマ,サイトメガロウイルス,パルボウイルスB19[Invited]Introduction scientific journal
- Mar. 2012, HORMONE FRONTIER IN GYNECOLOGY, 19(1号) (1号), 23 - 30, Japanese【不育症】 臨床編 抗リン脂質抗体症候群とその関連疾患[Invited]Introduction commerce magazine
- 日本産科婦人科学会, Feb. 2012, 日本産科婦人科学会雑誌, 64(2号) (2号), 844 - 844, Japanese肥満妊婦の臨床背景と体重増加についての検討Meeting report
- 日本産科婦人科学会, Feb. 2012, 日本産科婦人科学会雑誌, 64(2号) (2号), 704 - 704, Japanese妊娠中に透析療法を要した腎不全合併妊婦3症例Meeting report
- 日本産科婦人科学会, Feb. 2012, 日本産科婦人科学会雑誌, 64(2号) (2号), 561 - 561, Japanese妊娠29週未満早産児の予後不良に関連する因子Meeting report
- 日本産科婦人科学会, Feb. 2012, 日本産科婦人科学会雑誌, 64(2号) (2号), 524 - 524, Japanese特発性血小板減少性紫斑病合併妊娠の臨床像Meeting report
- Feb. 2012, 日本医学放射線学会学術集会抄録集, (71回) (71回), S144, Japanese先天性サイトメガロウィルス症 胎児MRIを中心にMeeting report
- 日本産科婦人科学会, Feb. 2012, 日本産科婦人科学会雑誌, 64(2号) (2号), 875 - 875, Japanese周産期母児管理におけるチーム医療の充実を期した助産師教育プログラム構築の試みMeeting report
- 日本産科婦人科学会, Feb. 2012, 日本産科婦人科学会雑誌, 64(2号) (2号), 703 - 703, Japanese甲状腺機能亢進症合併妊娠の帰結と新生児甲状腺機能異常Meeting report
- 日本産科婦人科学会, Feb. 2012, 日本産科婦人科学会雑誌, 64(2号) (2号), 728 - 728, JapaneseCMV IgM陽性妊婦における先天性CMV感染の発生予測Meeting report
- 日本産科婦人科学会, Feb. 2012, 日本産科婦人科学会雑誌, 64(2号) (2号), 519 - 519, Japanese75gOGTTにおける1点陽性と2点以上陽性GDM妊婦の背景と周産期帰結Meeting report
- 日本産科婦人科学会, Feb. 2012, 日本産科婦人科学会雑誌, 64(2号) (2号), 819 - 819, Japanese6回以上流産歴がある治療抵抗性・難治性習慣流産に対する60g免疫グロブリン療法Meeting report
- 日本産科婦人科学会, 2012, 日本産科婦人科學會雜誌, 64(2) (2), 889 - 889, EnglishISO-3-4 Renin is elevated in monochorionic diamniotic twins who have birthweight discordance but not twin-to-twin transfusion syndrome(Group 3 Perinatology,IS Award Candidate,International Session) :
- 2012, 産婦人科の実際, 61, 1043 - 1049, Japanese合併症妊娠の評価と管理～全身性エリテマトーデスと抗リン脂質抗体症候群 産科外来診療フローチャート～妊婦管理のすべて[Invited]Introduction commerce magazine
- Jan. 2012, 日本妊娠高血圧学会雑誌, 19, 145 - 147, Japanese治療に難渋したループス腎炎合併妊娠の1例Meeting report
- (一社)日本周産期・新生児医学会, Dec. 2011, 日本周産期・新生児医学会雑誌, 47(別冊) (別冊), 16 - 16, Japanese長期予後からみた出生前診断と治療 母体及び胎盤臍帯要因で極低出生体重児として出生した重度胎児発育不全児の3歳時の精神運動発達
- Nov. 2011, 産婦人科の進歩, 63(4号) (4号), 619, Japanese当院における妊娠糖尿病85例の妊娠中の管理および周産期帰結に関する検討[Refereed]
- Oct. 2011, 糖尿病と妊娠, 11(2号) (2号), S - 78, Japanese当院における妊娠糖尿病85例の妊娠中の管理および周産期帰結に関する検討[Refereed]
- 金原出版, 01 Oct. 2011, 産婦人科の実際, 60(10) (10), 1473 - 1480, Japanese不育症 最前線 不育症に対する免疫グロブリン療法
- 01 Sep. 2011, 産婦人科の実際, 60(9) (9), 1309 - 1321, Japanese産婦人科の遺伝医療と遺伝カウンセリング 周産期感染におけるカウンセリング―トキソプラズマとサイトメガロウイルス―
- Jun. 2011, 日本周産期・新生児医学会雑誌, 47(2号) (2号), 529, JapaneseSLE合併妊娠の転帰と抗リン脂質抗体の影響[Refereed]
- Jun. 2011, 日本産婦人科感染症研究会学術講演会記録集, (29号) (29号), 28 - 36, Japanese周産期におけるサイトメガロウイルス対策Introduction scientific journal
- Feb. 2011, 日本産科婦人科学会雑誌, 63(2号) (2号), 762, Japanese妊娠中に齲歯から感染性心内膜炎を発症した1例[Refereed]
- Feb. 2011, 日本産科婦人科学会雑誌, 63(2号) (2号), 761, Japanese高安病合併妊娠の2症例[Refereed]
- Feb. 2011, 日本産科婦人科学会雑誌, 63(2号) (2号), 754, JapaneseSLE合併妊娠の転帰[Refereed]
- 日本産科婦人科学会, Feb. 2011, 日本産科婦人科学会雑誌, 63(2号) (2号), 752 - 752, Japanese高血圧合併妊娠35症例の周産期予後に関する後方視的検討[Refereed]
- 日本産科婦人科学会, 2011, 日本産科婦人科學會雜誌, 63(2) (2), 761 - 761, JapaneseP2-12-2 高安病合併妊娠の2症例(Group90 合併症妊娠(症例)4,一般演題,第63回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2011, 日本産科婦人科學會雜誌, 63(2) (2), 733 - 733, JapaneseP2-9-3 先天性サイトメガロウイルス感染症の5症例(Group81 合併症妊娠(症例)1,一般演題,第63回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2011, 日本産科婦人科學會雜誌, 63(2) (2), 754 - 754, JapaneseP2-11-7 SLE合併妊娠の転帰(Group87 合併症妊娠(症例)3,一般演題,第63回日本産科婦人科学会学術講演会)
- 2011, 周産期医学, 41, 1081 - 1085, Japanese胎児の血液異常 パルボウイルス感染[Invited]Introduction commerce magazine
- 日本産科婦人科学会, 2010, 日本産科婦人科學會雜誌, 62(2) (2), 487 - 487, JapaneseP2-68 当科で管理した子宮内胎児死亡を伴う常位胎盤早期剥離症例の分娩様式に関する検討(Group52 妊娠分娩産褥6,一般演題,第62回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2009, 日本産科婦人科學會雜誌, 61(2) (2), 713 - 713, JapaneseP3-136 当院で管理した分娩前BMI30以上の妊婦の分娩様式に影響する因子の検討(Group93 妊娠分娩産褥9,一般演題,第61回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2008, 日本産科婦人科學會雜誌, 60(2) (2), 646 - 646, JapaneseP2-97 当科における双胎間輸血症候群(twin-to-twin transfusion syndrome;TTTS)関連疾患症例の検討(Group45 胎児・新生児の生理1,一般講演,第60回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2008, 日本産科婦人科學會雜誌, 60(2) (2), 558 - 558, JapaneseP1-184 当科で管理した妊娠28週以下のPROM症例における予後規定因子の検討(Group21 その他(乳房,避妊を含む)1,一般演題,第60回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2004, 日本産科婦人科學會雜誌, 56(2) (2), 468 - 468, Japanese11-37.トロホブラストにおけるbetacellulin(BTC)の生物利用 : BeWo細胞での検討(第53群 妊娠・分娩・産褥期5)(一般演題)
- 日本産科婦人科学会, 2003, 日本産科婦人科學會雜誌, 55(2) (2), 421 - 421, Japanese妊娠各期正常胎盤におけるEGF receptor family(ErbB1～ErbB4)発現態度の分子生物学的解析(第132群 妊娠・分娩・産褥15)
- 永井書店, Apr. 2001, 産婦人科治療 = Obstetrical and gynecological therapy, 82(4) (4), 499 - 502, JapaneseA case of cervical pregnancy successfully treated with intraarterial infusion of Actinomycin-D
- P-175 妊娠各期胎盤での絨毛性栄養膜細胞におけるEGF-familyの発現態度【目的】EGFはEGF受容体とともに妊娠4-5週胎盤ではcytotrophoblast(C細胞)に発現し, その増殖能を促進するが, 妊娠6-12週胎盤ではsyncytiotrophoblast(S細胞)に発現し, その分化機能を促進することを報告した.本研究では, EGF受容体と結合しEGF類似作用を有するEGF familyに属するHeparin-binding EGF-like growth factor(HB-EGF), TGF-α, Am-phiregulin(AR), Betacellulin(BTC)の絨毛性栄養膜細胞での妊娠経過に伴う発現態度を検討した.【方法】妊娠初期胎盤6例(妊娠4週-11週), 中期胎盤2例(妊娠12週-24週), 末期胎盤3例(妊娠37-40週)より患者の同意を得てえられた絨毛組織を用い, 絨毛性栄養膜細胞におけるHB-EGF, TGF-α, AR, BTCの発現をABA法で免疫組織学的に検討した.【成績】HB-EGF, TGF-αは妊娠初期の妊娠4-5週, 6-11週においてともにS細胞に局在し, C細胞における発現は観察されず, また, 妊娠中期, 末期ではその発現が観察されなかった.一方, AR, BTCは妊娠初期4-5週, 6-11週及び中期のS細胞に局在を認めたが, 妊娠末期にはAR, BTCの局在は観察されなかった.【結論】HB-EGF, TGF-αは妊娠初期胎盤のS細胞に, また, AR, BTCは妊娠初期及び中期胎盤のS細胞にその発現が観察されたが, 末期胎盤ではいずれの発現も陰性であったことより, これらのEGF familyはS細胞を舞台に, 妊娠初期及び中期における絨毛性栄養膜細胞の機能発現に関わる可能性が示唆された.日本産科婦人科学会, 2001, 日本産科婦人科學會雜誌, 53(2) (2), 437 - 437, Japanese
- Contributor, Q6.妊婦初期検査においてトキソプラズマ抗体陽性であった妊婦の取り扱いを教えてください, 中外医学社, Jul. 2022, ISBN: 9784498160361現場の疑問に答える周産期医療Q&A.
- Contributor, Ⅰ.産科疾患－E.産科感染症の管理と治療. 5.トキソプラズマ感染症., 南江堂, Dec. 2021, Japanese, ISBN: 9784524230563産科婦人科疾患最新の治療
- メジカルビュー, 2021不育症 ネオ・セルフ抗体
- Contributor, メジカルビュー, 2021不育症 産科的抗リン脂質抗体症候群の病因・病態
- Contributor, メディカ出版, 2020“Fetus as a Patient”胎児疾患と胎児治療 病態生理、診断・治療のすべて 先天性サイトメガロウイルス感染症に対する胎児治療
- Contributor, 東京医学社, 2020小児内科 特集 母子感染症の必須知識－エキスパートに学び予防につなげる 各病原体の母子管理―最新の疫学情報を含めて サイトメガロウイルス 『母体・胎児管理―胎児治療を含めて』
- Contributor, 谷村憲司、山田秀人, 2020臨床検査ガイド 2020年改訂版 これだけは必要な検査のすすめかた・データのよみかた 5.感染症検査 E.寄生虫 抗トキソプラズマ抗体
- Contributor, メディカ出版, 2020ペリネイタルケア2020年夏季増刊～妊産婦の保健指導トラの巻～助産師の指導・説明に役立つ回答・アドバイス集－第1章妊娠初期－④先天性トキソプラズマ症
- Contributor, 医学書院, 2020今日の治療指針 私はこう治療している 産婦人科疾患 妊娠と感染症.
- Contributor, メディカ出版, 2019基礎と臨床の両側面からみた胎盤学 Ⅱ章「胎盤の臨床」2. 前置胎盤・癒着胎盤 超音波診断.
- Contributor, 中外医学社, 2019不妊症・不育症診療 その伝承とエビデンス IV.不育症 2.診断と治療 10.不育症と抗リン脂質抗体
- Contributor, 東京医学社, 2019周産期医学特集号「周産期感染制御の最新情報」水痘・帯状疱疹.
- Contributor, メディカ出版, 2019ペリネイタルケア2019年新春増刊 「周産期のくすり大辞典」妊娠期・分娩期・産褥期・新生児の薬剤＆ワクチン133大解説～コラム 先天性サイトメガロウイルス感染の予防と胎児治療～
- Contributor, メディカ出版, 2019ペリネイタルケア2019年新春増刊 「周産期のくすり大辞典」妊娠期・分娩期・産褥期・新生児の薬剤＆ワクチン133大解説～21.感染症①トキソプラズマ～
- Others, メディカ出版, 2018, Japanese読める生かせる説明できる！産科の臨床検査ディクショナリー / 4-40. サイトメガロウイルス抗体General book
- Others, 金原出版, 2018, Japanese産婦人科感染症マニュアル 日本産科婦人科感染症学会編 / 9. 水痘・帯状発疹ウイルスScholarly book
- Others, 金原出版, 2018, Japanese産婦人科感染症マニュアル 日本産科婦人科感染症学会編 / 12. HIV感染症Scholarly book
- Others, Medical Review Co. Ltd., 2017, EnglishCommemorating the 60th anniversary of the establishment of Japan Thyroid Association, An extended edition of Journal of the Japan Thyroid Association "Thyroid Hormones and Their Related Diseases" / Thyroid hormones and pregnancy/infertility/recurrent pregScholarly book
- Others, 科学評論社, Feb. 2016, Japanese臨床免疫・アレルギー科 / β2-グリコプロテイン-I/HLA classII複合体は抗リン脂質抗体症候群の標的抗原であるScholarly book
- Others, 南江堂, Feb. 2016, Japanese産科婦人科疾患 最新の治療 2016-2018 / 産科感染症の管理と治療 STDScholarly book
- Others, 東京医学社, 2016, Japanese周産期医学 必須知識 第8版 / [感染] 39. トキソプラズマScholarly book
- Others, メディカ出版, Aug. 2015, Japanese改訂3版 MFICUマニュアル / 周産期感染症の管理と処置 HIVScholarly book
- Others, 医歯薬出版株式会社, Jun. 2015, Japanese医学のあゆみ / 【母子感染Update】 トキソプラズマ(解説/特集)Scholarly book
- Others, メディカ出版, Jun. 2015, Japaneseペリネイタルケア / 【病態生理・保健指導・分娩管理 事例で学ぶハイリスク妊娠3ステップ】 甲状腺疾患合併妊娠(解説/特集)Scholarly book
- Others, メディカルレビュー社, Apr. 2015, JapaneseFetal & Neonatal Medicine / 注目のTopics サイトメガロウイルスの治療 先天性サイトメガロウイルス感染の予防と胎児治療Scholarly book
- Others, 文光堂, Mar. 2015, Japanese臨床検査ガイド 2015年改訂版 これだけは必要な検査のすすめかた・データのよみかた / 寄生虫 抗トキソプラズマ抗体Scholarly book
- Others, 文光堂, Mar. 2015, Japanese臨床検査ガイド / 抗トキソプラズマ抗体Scholarly book
- Contributor, 1213-1218, 東京医学社, 2014周産期医学 「【重篤な疾患を合併する妊産婦の管理】血液疾患 特発性血小板減少性紫斑病（Idiopathic thrombocytopenic purpura）」
- Others, In Tech, Apr. 2012, EnglishAntiphospholipid syndrome / The management of antiphospholipid antibodies affected pregnancyScholarly book
- Contributor, 23-30, メジカルビュー, 2012ホルモンフロンティア 特集不育症「抗リン脂質抗体症候群とその関連病態」
- Contributor, 166-174, 医学書院, 2012臨床婦人科産科増刊号「オフィスギネコロジー」母児感染の管理「トキソプラズマ,サイトメ ガロウイルス,パルボウイルスB19」
- Contributor, 121-125, 東京医学社, 2012周産期医学増刊号『抗リン脂質抗体検査』
- Contributor, 文光堂, 2006Medical Practice 第一線医師･研修医･コメディカルのための新・輸液ガイドすぐ役立つ手技・手法のすべて『妊産婦、妊娠高血圧症候群（旧妊娠中毒症）患者の輸液法』
- 第58回日本周産期・新生児医学会学術集会, Jul. 2022, Japanese先天性サイトメガロウイルス感染症の予防と胎児治療[Invited]Nominated symposium
- 第4回日本不育症学会学術集会, Jun. 2022, Japaneseネオセルフ抗体陽性不育症患者に対する治療法の検討Oral presentation
- 第32回日本産婦人科・新生児血液学会, Jun. 2022, Japanese先天性サイトメガロウイルス感染症[Invited]Nominated symposium
- 第81回日本医学放射線学会総会, Apr. 2022, Japanese分娩後出血・癒着胎盤の治療戦略[Invited]Nominated symposium
- The 22nd Annual Symposium Japanese Society for the Advancement of Women’s Imaging, Sep. 2021Workshop1 「胎児の頭蓋内病変」 症候性先天性サイトメガロウイルス感染症における胎児MRIの意義[Invited]Nominated symposium
- 第39日本受精着床学会総会・学術講演会, Jul. 2021不育症の新規リスク因子としてのネオ・セルフ抗体 シンポジウム1「リスク因子不明不育症の解明に挑む」[Invited]Nominated symposium
- 第144回近畿産科婦人科学会総会ならびに学術集会, Jun. 2021, Japanese症候性先天性サイトメガロウイルス感染症に対する胎児治療と新生児治療の 有効性の検討Oral presentation
- 第37回日本産婦人科感染症学会学術集会, May 2021トキソプラズマ-IgG avidity index高値母体から発生した先天性トキソプラズマ感染疑いの1例Oral presentation
- 第73回日本産科婦人科学会学術講演会, Apr. 2021HLAクラスⅡ分子の新しい抗原提示機能を応用した不育症・産科異常症の病態解明ならびに治療法開発を目指した基礎ならびに臨床研究 第12回ロート女性健康科学研究賞 授賞式・受賞記念講演[Invited]Nominated symposium
- 第94回日本内分泌学会学術総会, Apr. 2021甲状腺機能亢進症合併妊娠の管理～産科側から～ クリニカルアワー2「バセドウ病の妊娠前・妊娠中の管理」[Invited]Nominated symposium
- 第73回日本産科婦人科学会学術講演会, Mar. 2021, EnglishAutoantibody against β2-glycoprotein I/HLA-DR complexes in women with adverse obstetric eventsPoster presentation
- 第28回日本胎盤学会学術集会, Oct. 2020抗β2グリコプロテインⅠ/HLAクラスⅡ複合体抗体は不育症の主要リスク因子であるOral presentation
- 第143回近畿産科婦人科学会学術集会 周産期研究部会, Oct. 2020精神疾患合併妊娠の妊娠中・産後増悪誘因ならびに児への影響に関する検討Oral presentation
- 第38回日本受精着床学会総会・学術講演会, Oct. 2020自己免疫疾患としての不育症[Invited]Nominated symposium
- 第142回近畿産科婦人科学会学術講演会, Jun. 2020トキソプラズマIgG avidity index高値母体から発生した先天性トキソプラズマ感染疑いの1例Oral presentation
- 第72回日本産科婦人科学会学術講演会, Apr. 2020, EnglishAutoantibody against β2-glycoprotein I/HLA class II complexes as a new marker for antiphospholipid syndromePoster presentation
- AMED 成育疾患克服等総合研究事業「母子感染に対する母子保健体制構築と医療開発技術のための研究」平成30年度第2回班会議, Dec. 2018, Japanese, 東京, Domestic conference先天性サイトメガロウイルス感染発生に関連する臨床・検査所見Others
- 第63回日本新生児成育医学会学術集会, Nov. 2018, Japanese, 東京, Domestic conference母子感染：予防と対策 兵庫県の妊婦梅毒症例からみた梅毒母子感染の予防と対策における課題Nominated symposium
- 第33回日本生殖免疫学会総会・学術集会, Nov. 2018, Japanese, 東京, Domestic conference不育症リスク因子としてのネオ・セルフ抗体Oral presentation
- 第33回日本生殖免疫学会総会・学術集会, Nov. 2018, Japanese, 東京, Domestic conference妊娠初期のプロテインS低値と産科異常との関連Oral presentation
- 第33回日本生殖免疫学会総会・学術集会, Nov. 2018, Japanese, 東京, Domestic conference切迫流早産と腟内マイクロバイオームとの関連性Oral presentation
- 第39回日本妊娠高血圧学会学術集会, Nov. 2018, Japanese, 大阪, Domestic conference維持透析療法を要した腎不全合併妊娠4例Oral presentation
- 第59回日本母性衛生学会総会・学術集会, Oct. 2018, Japanese, 新潟, Domestic conference分娩後出血に対するUAEの帰結およびUAE後の妊娠についての検討Poster presentation
- 第59回日本母性衛生学会総会・学術集会, Oct. 2018, Japanese, 新潟, Domestic conference梅毒合併妊娠の7例Oral presentation
- 第45回日本産婦人科医会学術集会, Oct. 2018, Japanese, 大阪, Domestic conference妊婦抗体スクリーニングおよび臨床所見による先天性サイトメガロウイルス感染の発生予知Poster presentation
- 第59回日本母性衛生学会総会・学術集会, Oct. 2018, Japanese, 新潟, Domestic conference神戸大学における不育症の臨床因子と妊娠予後の検討Poster presentation
- 第63回日本生殖医学会学術講演会・総会, Sep. 2018, Japanese, 旭川, Domestic conference不育症のトピックス～不育症とネオ・セルフNominated symposium
- The 20th congress of federation of asia oceania perinatal societies (FAOPS), Sep. 2018, English, Manila, International conferencePregnancy outcomes subsequent to uterine arterial embolization for severe post-partum hemorrhagePoster presentation
- International federation of placenta associations (IFPA) 2018 Tokyo, Sep. 2018, English, Tokyo, International conferencePlacental pathology of congenital cytomegalovirus infectionPoster presentation
- 第41回日本母体胎児医学会学術集会, Aug. 2018, Japanese, 東京, Domestic conference梅毒合併妊娠の7症例Oral presentation
- 第42回日本産科婦人科栄養・代謝研究会, Aug. 2018, Japanese, 東京, Domestic conference胎児甲状腺腫を来たしたT3優位型バセドウ病合併妊娠の2例Oral presentation
- 第41回日本母体胎児医学会学術集会, Aug. 2018, Japanese, 東京, Domestic conference胎児甲状腺腫を来たしたT3優位型バセドウ病合併妊娠の2例Oral presentation
- 第42回日本産科婦人科栄養・代謝研究会, Aug. 2018, Japanese, 東京, Domestic conferenceメトホルミンが著効したインスリン抵抗症合併妊娠の1例Oral presentation
- 第92回兵庫県産婦人科学会学術集会, Jul. 2018, Japanese, 神戸, Domestic conference兵庫県産婦人科施設を対象とした梅毒アンケート調査結果と今後の課題Oral presentation
- 第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conference兵庫県における女性の梅毒症例の動向と課題Oral presentation
- 第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conference妊婦のB型肝炎スクリーニングと垂直感染予防Oral presentation
- 第 54 回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京都, Domestic conference尿サイトメガロウイルス（CMV）スクリーニングで同定した先天性CMV感染児の前方視的観察研究Oral presentation
- 第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conference当院不育症外来における不育症リスク因子と治療成績Poster presentation
- 第 54 回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京都, Domestic conference当院における先天性トキソプラズマ感染症の発生に関する臨床前向き研究Oral presentation
- 第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conference胎児発育不全児の予後不良に関連する因子の検討Oral presentation
- 第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conference先天性サイトメガロウイルス感染の胎盤病理Oral presentation
- 第92回兵庫県産婦人科学会学術集会, Jul. 2018, Japanese, 神戸, Domestic conference切迫早産と腟内マイクロバイオームとの関連性の検討Oral presentation
- 第 54 回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京都, Domestic conference症候性先天性CMV感染児の1歳6か月時点でのDQ＜70と関連する新生児期リスク因子の後方視的検討Oral presentation
- 第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conference症候性の先天性サイトメガロウイルス感染症に対する胎児治療と新生児治療Oral presentation
- 第92回兵庫県産婦人科学会学術集会, Jul. 2018, Japanese, 神戸, Domestic conference最近管理した梅毒合併妊婦7症例Oral presentation
- AMED成育疾患克服等次世代育成基盤研究事業「不育症の原因解明、予防治療に関する研究」平成30年度 第1回班会議, Jul. 2018, Japanese, 東京, Domestic conference抗β2GPI/HLA-DR抗体と不育、産科異常との関連解明と治療指針の確立Others
- 第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conference維持透析療法を要した腎不全合併妊娠3例Oral presentation
- 第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conferenceトキソプラズマ妊婦スクリーニングの前向きコホート研究Poster presentation
- 第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conferenceトキソプラズマ抗体妊婦スクリーニングの前向きコホート研究Poster presentation
- 第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conferenceUAE後の妊娠では産後出血に注意が必要であるOral presentation
- 第138回近畿産科婦人科学会総会, Jun. 2018, Japanese, 大阪, Domestic conference妊婦のB型肝炎スクリーニングと垂直感染予防Oral presentation
- 第138回近畿産科婦人科学会総会, Jun. 2018, Japanese, 大阪, Domestic conferencePPAPスコアリングシステムを用いた前置胎盤の管理Oral presentation
- The 38th annual meeting of the american sciety for reproductive immunology, Jun. 2018, English, Shanghai, International conferenceAutoantibodies against β2-glycoprotein I/HLA class II complexes in women with recurrent pregnancy lossOral presentation
- 第35回日本産婦人科感染症学会学術集会, May 2018, Japanese, 岐阜, Domestic conference兵庫県における女性梅毒症例の動向と課題Oral presentation
- 第35回日本産婦人科感染症学会学術集会, May 2018, Japanese, 岐阜, Domestic conference症候性の先天性サイトメガロウイルス感染症に対する胎児治療と新生児治療の有効性Oral presentation
- 第35回日本産婦人科感染症学会学術集会, May 2018, Japanese, 岐阜, Domestic conferenceトキソプラズマ抗体妊婦スクリーニングに関する前向きコホート研究Oral presentation
- 第70回日本産科婦人科学会学術講演会, May 2018, English, 仙台, Domestic conferenceThe distribution of etiology and therapy outcomes of recurrent pregnancy loss at our recurrent pregnancy loss clinicPoster presentation
- 第70回日本産科婦人科学会学術講演会, May 2018, English, 仙台, Domestic conferenceRisk factors for congenital cytomegalovirus infection in pregnant women with non-primary infectionOthers
- 第70回日本産科婦人科学会学術講演会, May 2018, English, 仙台, Domestic conferencePrenatal genetic diagnosis for neonatal alloimmune thrombocytepenia for women with the history of neonatal alloimmune thrombocytopeniaPoster presentation
- 第70回日本産科婦人科学会学術講演会, May 2018, English, 仙台, Domestic conferencePregnancy outcomes subsequent to uterine arterial embolization for severe post-partum hemorrhagePoster presentation
- 第70回日本産科婦人科学会学術講演会, May 2018, English, 仙台, Domestic conferenceImmunoglobulin fetal therapy for symptomatic congenital cytomegalovirus infectionPoster presentation
- 第35回日本産婦人科感染症学会学術集会, May 2018, Japanese, 岐阜, Domestic conferenceHBV妊婦スクリーニングと母子感染予防の前向き研究Oral presentation
- 第70回日本産科婦人科学会学術講演会, May 2018, English, 仙台, Domestic conferenceEfficacy of maternal screening and perinatal prevention program for hepatitis BPublic symposium
- 第70回日本産科婦人科学会学術講演会, May 2018, English, 仙台, Domestic conferenceDomainV of β2GPI has very high affinity with MHC class IIPoster presentation
- 第32回日本生殖免疫学会総会・学術集会, Dec. 2017, Japanese, 日本生殖免疫学会, 東京, Domestic conference先天性サイトメガロウイルス感染児の聴性脳幹反応に対する抗ウイルス薬治療の効果Oral presentation
- 第32回日本生殖免疫学会総会・学術集会, Dec. 2017, Japanese, 日本生殖免疫学会, 東京, Domestic conference抗ウイルス薬治療を行った症候性先天性サイトメガロウイルス感染児の1歳6か月時の神経学的予後評価と予後不良因子の検討Oral presentation
- 第32回日本生殖免疫学会総会・学術集会, Dec. 2017, Japanese, 日本生殖免疫学会, 東京, Domestic conferenceトキソプラズマ妊婦スクリーニングの前向きコホート研究Oral presentation
- 第32回日本生殖免疫学会総会・学術集会, Dec. 2017, Japanese, 日本生殖免疫学会, 東京, Domestic conferenceサイトメガロウイルス[Invited]Nominated symposium
- 第53回日本周産期・新生児医学会学術集会, Jul. 2017, Japanese, 日本周産期・新生児医学会, 横浜, Domestic conference先天性CMV感染児の出生体重と神経学的予後に関する検討Oral presentation
- 第69回日本産科婦人科学会学術集会, May 2017, Japanese, 日本産婦人科学会, 広島, Domestic conference胎児腹水を呈した症候性先天性サイトメガロウイルス感染症3例の出生後の臨床経過Poster presentation
- 第60回日本糖尿病学会年次学術集会, May 2017, Japanese, 日本糖尿病学会, 名古屋, Domestic conference持続血糖モニターを用いた妊娠糖尿病患者における分娩中の血糖動態の検討Poster presentation
- 第34回日本産婦人科感染症学会, May 2017, Japanese, 日本産婦人科感染症学会, 奈良, Domestic conferenceトキソプラズマ妊婦スクリーニングの前向き研究Oral presentation
- 21st International Conference on Prenatal Diagnosis and Therapy, May 2017, English, International Society for Prenatal Diagnosis, San Diego, USA, International conferenceTwo cases of prenatal genetic diagnosis for neonatal alloimmune thrombocytopenia for women with the history of neonatal alloimmune thrombocytopenia in the prior pregnancyPoster presentation
- 21st International Conference on Prenatal Diagnosis and Therapy, May 2017, English, International Society for Prenatal Diagnosis, San Diego, USA, International conferenceNoninvasive methods for predicting congenital cytomegalovirus infection in high-risk pregnant womenPoster presentation
- 第69回日本産科婦人科学会学術集会, May 2017, Japanese, 日本産婦人科学会, 広島, Domestic conferenceEfficacy of maternal serological screening for congenital cytomegalovirus infectionPoster presentation
- 第31回日本生殖免疫学会, Dec. 2016, Japanese, 日本生殖免疫学会, 神戸, Domestic conference妊婦のサイトメガロウイルス抗体スクリーニングの有用性Oral presentation
- 第32回日本糖尿病・妊娠学会学術集会, Dec. 2016, Japanese, 日本糖尿病・妊娠学会, 岡山, Domestic conferenceインスリン使用/非使用GDM症例におけるインスリン分泌能・感受性指標の比較Oral presentation
- 第52回日本周産期・新生児医学会学術集会, Jul. 2016, Japanese, 日本周産期・新生児医学会, 富山, Domestic conference胎児甲状腺機能亢進症を来たしたT3優位型バセドウ病合併妊娠の1例Poster presentation
- 第52回日本周産期・新生児医学会学術集会, Jul. 2016, Japanese, 日本周産期・新生児医学会, 富山, Domestic conference新生児同種免疫性血小板減少症の3例Poster presentation
- 第52回日本周産期・新生児医学会学術集会, Jul. 2016, Japanese, 日本周産期・新生児医学会, 富山, Domestic conferenceシンポジウム：本邦におけるパルボウイルスB19母子感染の実態[Invited]Nominated symposium
- 第33回日本産婦人科感染症学会学術集会, Jul. 2016, Japanese, 日本産婦人科感染症学会, 東京, Domestic conferenceMycoplasma hominisisによる子宮内感染から新生児遷延性肺高血圧症を呈した早産児の1例Oral presentation
- 第34回日本産婦人科感染症学会学術集会, Jul. 2016, Japanese, 日本産婦人科感染症学会, 東京, Domestic conferenceIgG avidity とPCR 法を用いたサイトメガロウイルス妊婦スクリーニングOral presentation
- 第134回近畿産科婦人科学会, Jun. 2016, Japanese, 近畿産科婦人科学会, 京都, Domestic conference胎児甲状腺機能亢進症を来たしたTRAb著明高値バセドウ病合併妊娠の一例Oral presentation
- 第134回近畿産科婦人科学会, Jun. 2016, Japanese, 近畿産科婦人科学会, 京都, Domestic conferenceIgG avidityとPCR法を用いたサイトメガロウイルス妊婦スクリーニングOral presentation
- 第68回日本産科婦人科学会, Apr. 2016, Japanese, 日本産科婦人科学会, 東京, Domestic conference先天性サイトメガロウイルス感染症児における生後早期の頭部MRI所見Poster presentation
- 第68回日本産科婦人科学会, Apr. 2016, Japanese, 日本産科婦人科学会, 東京, Domestic conference新生児同種免疫性血小板減少症の2例：過去の妊娠で児が新生児同種免疫性血小板減少症を発症した女性の周産期管理Poster presentation
- 第68回日本産科婦人科学会, Apr. 2016, Japanese, 日本産科婦人科学会, 東京, Domestic conferenceThe effect of maternal screening for HBV and perinatal HBV prevention programPoster presentation
- 第68回日本産科婦人科学会, Apr. 2016, Japanese, 日本産科婦人科学会, 東京, Domestic conferenceMaternal blood screening for congenital cytomegalovirus infection of the infantsPoster presentation
- 第34回周産期学シンポジウム, Feb. 2016, Japanese, 日本周産期新生児医学会, 神戸, Domestic conference「母児の予後からみた娩出のタイミングと方法」、癒着胎盤予測スコアを用いた前置胎盤の手術管理Public symposium
- 第1回産婦人科遺伝診療学会, Dec. 2015, Japanese, 産婦人科遺伝診療学会, 長崎, Domestic conference先天性アンチトロンビン欠乏症合併妊婦における遺伝子解析結果と臨床像の検討Oral presentation
- 第31回日本糖尿病・妊娠学会年次学術集会, Nov. 2015, Japanese, 日本糖尿病・妊娠学会, 東京, Domestic conference糖代謝異常合併妊娠における 必要インスリンの増加量および関連因子の検討Oral presentation
- 第31回日本糖尿病・妊娠学会年次学術集会, Nov. 2015, Japanese, 日本糖尿病・妊娠学会, 東京, Domestic conference1型糖尿病合併妊娠患者における 産後の血糖コントロールに 関する検討Oral presentation
- 第38回日本母体胎児医学会, Oct. 2015, Japanese, 日本母体胎児医学会, 別府, Domestic conference妊娠中に急性増悪を来したＢ型肝炎ウイルスキャリア妊婦の2例Oral presentation
- 第51回日本周産期・新生児医学会総会学術集会, Jul. 2015, Japanese, 日本周産期・新生児医学会, 福岡, Domestic conference新生児尿スクリーニングと抗ウイルス薬治療導入後の症候性先天性サイトメガロウイルス感染児の後遺症発生率Oral presentation
- 15th Annual Meeting of Asian & Oceanic Society for Pediatric Radiology, Jun. 2015, English, AOSPR, 東京, International conferenceComparison between fetal and postnatal imaging in the detection of cerebral abnormalities of congenital cytomegalovirus infection.Poster presentation
- 第32回日本産婦人科感染症学会学術講演会, May 2015, Japanese, 日本産婦人科感染症学会, 宇都宮, Domestic conference新生児尿スクリーニングと抗ウイルス薬治療導入後の症候性先天性サイトメガロウイルス感染児の後遺症発生率Oral presentation
- 第32回日本産婦人科感染症学会学術講演会, May 2015, Japanese, 日本産婦人科感染症学会, 宇都宮, Domestic conference症候性先天性サイトメガロウイルス感染児の聴性脳幹反応に対する抗ウイルス薬治療の効果と問題点Oral presentation
- 第32回日本産婦人科感染症学会学術講演会, May 2015, Japanese, 日本産婦人科感染症学会, 宇都宮, Domestic conferenceサイトメガロウイルス胎児感染の母体IgG avidity indexは急速に上昇するOral presentation
- 第32回日本産婦人科感染症学会学術講演会, May 2015, Japanese, 日本産婦人科感染症学会, 宇都宮, Domestic conferenceサイトメガロウイルスIgM 陽性妊婦における先天性感染発生の予測因子Oral presentation
- 第32回日本産婦人科感染症学会学術講演会, May 2015, Japanese, 日本産婦人科感染症学会, 宇都宮, Domestic conferenceIgG avidity とPCR 法を用いたサイトメガロウイルス妊婦スクリーニングOral presentation
- 第67回日本産科婦人科学会学術講演会, Apr. 2015, Japanese, 日本産科婦人科学会, 横浜, Domestic conference免疫グロブリンを用いたサイトメガロウイルス胎児感染予防と胎児治療Poster presentation
- 第67回日本産科婦人科学会学術講演会, Apr. 2015, Japanese, 日本産科婦人科学会, 横浜, Domestic conference全新生児を対象とした尿サイトメガロウイルススクリーニングの臨床的有用性Poster presentation
- 第67回日本産科婦人科学会学術講演会, Apr. 2015, Japanese, 日本産科婦人科学会, 横浜, Domestic conference先天性トキソプラズマ感染の出生前予測に有用なトキソプラズマIgG avidity index cut-off 値Oral presentation
- 第67回日本産科婦人科学会学術講演会, Apr. 2015, Japanese, 日本産科婦人科学会, 横浜, Domestic conference切迫早産入院管理の結果、妊娠29週未満で早産となった児の予後解析Poster presentation
- 第67回日本産科婦人科学会学術講演会, Apr. 2015, Japanese, 日本産科婦人科学会, 横浜, Domestic conference症候性先天性サイトメガロウイルス感染児の聴性脳幹反応に対する抗ウイルス薬治療の効果Poster presentation
- 第67回日本産科婦人科学会学術講演会, Apr. 2015, Japanese, 日本産科婦人科学会, 横浜, Domestic conference抗SS-A抗体陽性妊婦の胎児大動脈-上大静脈房室伝導時間スクリーニングと先天性完全房室ブロックの発生予防Poster presentation
- 第67回日本産科婦人科学会学術講演会, Apr. 2015, Japanese, 日本産科婦人科学会, 横浜, Domestic conferenceサイトメガロウイルスIgM陽性妊婦における先天性感染発生の予知因子Oral presentation
- 5th International Congenital CMV Conference, Apr. 2015, English, The QIMR Berghofer Medical Research Institute, Brisbane, オーストラリア, International conferenceIncidence of sequelae in symptomatic congenital cytomegalovirus-infected infants after introduction of newborn urine screening and antiviral treatment.Poster presentation
- Asian Society for Pediatric Research, Apr. 2015, English, osaka, Japan, International conferenceFollow-Up Study of Infants With Symptomatic Congenital Cytomegalovirus Infection Diagnosed by Urine Screening Soon After BirthPoster presentation
- Pediatric Academic Societies Annual Meeting, Apr. 2015, English, Pediatric Academic Societies, San Diego, アメリカ, International conferenceEfficacy of antiviral treatment on abnormal auditory brainstem responses in congenital cytomegalovirus-infected infants.Poster presentation
- 5th International Congenital CMV Conference, Apr. 2015, English, The QIMR Berghofer Medical Research Institute, Brisbane, オーストラリア, International conferenceEfficacy of antiviral treatment on abnormal auditory brainstem responses in congenital cytomegalovirus-infected infants.Poster presentation
- 2015 Pediatric Academic Society Annual Meeting, Apr. 2015, English, osaka, Japan, International conferenceEfficacy of Antiviral Treatment on Abnormal Auditory Brainstem Responses in Congenital Cytomegalovirus-Infected InfantsPoster presentation
- 第67回日本産科婦人科学会学術講演会, Apr. 2015, English, 日本産科婦人科学会, 横浜, Domestic conferenceA rapid increase of serum IgG avidity index in women with a congenital cytomegalovirus infection.Poster presentation
- 第29回日本生殖免疫学会学術集会, Dec. 2014, Japanese, 日本生殖免疫学会, 東京, Domestic conferenceプロテインS低下女性に対する遺伝子検査の現状Oral presentation
- 厚生労働科学研究助成金（成育疾患克服等次世代育成基盤研究事業）『母子感染の実態把握及び検査・治療に関する研究』平成26年度第3回会議, Dec. 2014, Japanese, 東京, Domestic conferenceサイトメガロウイルスIgM陽性妊婦における先天性感染発生予知のための前方視的研究Oral presentation
- 第59回日本人類遺伝学会・第21回日本遺伝子診療学会合同大会, Nov. 2014, Japanese, 日本人類遺伝学会・日本遺伝子診療学会, 東京, Domestic conference先天性アンチトロンビン欠乏症合併妊婦における血栓塞栓症の管理～遺伝子解析結果と臨床像の検討～Oral presentation
- 第30回日本糖尿病・妊娠学会年次学術集会, Nov. 2014, Japanese, 日本糖尿病・妊娠学会, 長崎, Domestic conference受容体以後のシグナル伝達障害によるインスリン抵抗症を合併し、妊娠中もメトホルミン投与を要した一例Oral presentation
- 第30回糖尿病・妊娠学会年次学術集会, Nov. 2014, Japanese, 糖尿病・妊娠学会, 長崎, Domestic conference受容体以後のシグナル伝達障害によるインスリン抵抗症が疑われ妊娠中メトホルミンが著効した1例Oral presentation
- 第57回日本甲状腺学会学術集会, Nov. 2014, Japanese, 日本甲状腺学会, 大阪, Domestic conferenceバセドウ病合併妊娠における産科異常と新生児甲状腺機能異常発症の危険因子の検討Oral presentation
- 第131回近畿産科婦人科学会学術集会, Oct. 2014, Japanese, 近畿産科婦人科学会, 大阪, Domestic conference免疫グロブリン投与によるサイトメガロウイルス母子感染予防の試みOral presentation
- 第38回日本産婦人科手術学会, Oct. 2014, Japanese, 日本産婦人科手術学会, 札幌, Domestic conference内腸骨動脈閉鎖バルーンカテーテルを用いた前置癒着胎盤に対する帝王切開術Oral presentation
- 神戸大学産科婦人科オータムフォーラム, Oct. 2014, Japanese, 神戸大学, 高松, Domestic conference胎児超音波パルスドプラ法の基礎から応用までPublic discourse
- 第131回近畿産科婦人科学会学術集会, Oct. 2014, Japanese, 近畿産婦人科学会, 大阪, Domestic conference先天性トキソプラズマ感染症の出生前予測に有用なトキソプラズマ IgG avidity index cut-off値Oral presentation
- 第131回近畿産科婦人科学会学術集会, Oct. 2014, Japanese, 近畿産科婦人科学会, 大阪, Domestic conference症候性先天性サイトメガロウイルス感染に対する免疫グロブリンを用いた胎児治療Oral presentation
- 第131回近畿産科婦人科学会学術集会, Oct. 2014, Japanese, 近畿産婦人科学会, 大阪, Domestic conference治療抵抗性の抗リン脂質抗体症候群合併妊娠に対する大量免疫グロブリン療法Oral presentation
- 第131回近畿産科婦人科学会学術集会, Oct. 2014, Japanese, 近畿産婦人科学会, 大阪, Domestic conferenceプロテインS低下女性に対する遺伝子検査の現状Oral presentation
- 第50回日本周産期・新生児医学会学術集会, Jul. 2014, Japanese, 日本周産期・新生児医学会, 千葉, Domestic conference胎盤トキソプラズマ感染を認めた2例Poster presentation
- 第50回日本周産期・新生児医学会学術集会, Jul. 2014, Japanese, 日本周産期・新生児医学会, 浦安, Domestic conference胎盤トキソプラズマ感染を認めた2症例Oral presentation
- 第50回日本周産期・新生児医学会学術集会, Jul. 2014, Japanese, 日本周産期・新生児医学会, 千葉, Domestic conference近年日本における母子感染の実態Oral presentation
- 第50回日本周産期・新生児医学会学術集会, Jul. 2014, Japanese, 日本周産期・新生児医学会, 浦安, Domestic conferenceインスリン治療を要した妊娠糖尿病妊婦の臨床像Oral presentation
- 39th Annual International Herpesvirus Workshop, Jul. 2014, English, Kobe, Japan, International conferenceThe IgG avidity value for the prediction of congenital cytomegalovirus infection in a prospective cohort study[Invited]Nominated symposium
- 39th Annual International Herpesvirus Workshop, Jul. 2014, English, Kobe, Japan, International conferenceRapid increase in CMV IgG avidity correlates with cytomegalovirus transmission to the fetusPoster presentation
- 第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference母体血サイトメガロウイルスIgG avidity 測定による先天性感染の発生予知Oral presentation
- 第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference妊娠中の水痘初感染により子宮内胎児死亡に至った1例Oral presentation
- 第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference全国妊婦健診施設を対象とした妊婦感染症スクリーニングと先天性感染の実態調査Oral presentation
- 第55回日本臨床ウイルス学会, Jun. 2014, Japanese, 日本臨床ウイルス学会, 札幌, Domestic conference全国産科施設を対象としたパルボウイルスB19母子感染の実態調査Oral presentation
- 第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference全国産科施設を対象としたパルボウイルスB19母子感染の実態調査Oral presentation
- 第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference全国産科施設を対象としたCMV、トキソプラズマ、風疹、梅毒、単純ヘルペス母子感染の実態調査Oral presentation
- 第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference先天性サイトメガロウイルス（CMV）感染の診断における新生児血中CMV-IgM、アンチゲネミア、CMV-DNA の意義Oral presentation
- 第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference症候性先天性サイトメガロウイルス感染児に対する抗ウイルス薬治療Oral presentation
- 第88回兵庫県産科婦人科学会学術集会, Jun. 2014, Japanese, 日本産科婦人科学会, 神戸, Domestic conference周産期リステリア症の2例Oral presentation
- 第88回兵庫県産科婦人科学会学術集会, Jun. 2014, Japanese, 日本産科婦人科学会, 神戸, Domestic conference筋強直性ジストロフィー合併妊娠の2例Oral presentation
- 第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conferenceサイトメガロウイルス先天性感染例においてIgG avidity index は急速に増加するOral presentation
- 第55回日本臨床ウイルス学会, Jun. 2014, Japanese, 日本臨床ウイルス学会, 札幌, Domestic conferenceサイトメガロウイルス先天性感染例においてIgG avidity indexは急速に増加するOral presentation
- The 39th Annual International Herpesvirus Workshop, Jun. 2014, English, NOVARTIS, 神戸, International conferenceThe IgG avidity value for the prediction of congenital cytomegalovirus infection in a prospective cohort study.Poster presentation
- The 39th Annual International Herpesvirus Workshop, Jun. 2014, English, NOVARTIS, 神戸, International conferenceRapid increase in CMV IgG avidity correlates with cytomegalovirus transmission to the fetus.Poster presentation
- The 39th Annual International Herpesvirus Workshop, Jun. 2014, English, NOVARTIS, 神戸, International conferenceProphylactic intravenous immunoglobulin injections to mothers with primary cytomegalovirus infection.Poster presentation
- 第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conferenceMHCクラスII の新しい抗原提示機能は抗リン脂質抗体症候群の病態と関連するOral presentation
- The 39th Annual International Herpesvirus Workshop, Jun. 2014, English, NOVARTIS, 神戸, International conferenceLow total IgM values and high cytomegalovirus loads in the blood of newborns with symptomatic congenital cytomegalovirus infection.Poster presentation
- 第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conferenceIgG AvidityとPCR法を用いたサイトメガロウイルス妊婦スクリーニング【シンポジウム】母子感染～妊婦スクリーニングの効果と課題～Public symposium
- 第130回近畿産科婦人科学会学術集会, Jun. 2014, Japanese, 近畿産科婦人科学会, 大阪, Domestic conferenceIgG avidityとPCR法を用いたサイトメガロウイルス妊婦スクリーニングOral presentation
- 第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference不育症および自己免疫疾患における抗リン脂質抗体陽性患者の妊娠帰結Poster presentation
- 第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference治療抵抗性の抗リン脂質抗体症候群合併妊娠に対する大量免疫グロブリン療法Poster presentation
- 第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference近年日本における母子感染の実態Poster presentation
- 第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference近年における母子感染の実態Poster presentation
- 第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference急速なIgG Avidity index上昇はサイトメガロウイルス先天性感染の発生予知因子であるPoster presentation
- 第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conferenceIgG avidityとPCR法を用いたサイトメガロウイルス妊婦スクリーニングPoster presentation
- 第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conferenceHLAクラスII/β2-glycoprotein Iタンパク質複合体は抗リン脂質抗体症候群の病態に関わる主要な標的分子である。Poster presentation
- 平成26年度位育会総会, Feb. 2014, Japanese, 位育会, 神戸, Domestic conferenceMHC class IIの新しい抗原提示機構は抗リン脂質抗体症候群の病態に関連するOthers
- 第5回神戸産婦人科臨床フォーラム, Jan. 2014, Japanese, 兵庫県産科婦人科学会, 神戸, Domestic conferenceIgG avidityとPCR法を用いたサイトメガロウイルス妊婦スクリーニングOral presentation
- 平成25年度大阪大学微生物病研究所業績発表会, Jan. 2014, Japanese, 大阪大学, 大阪, Domestic conferenceCellular misfolded proteins transported to the cell surface by MHC class II molecules are targets for autoantibodies in autoimmune diseasesOral presentation
- 第49回日本周産期・新生児医学会学術集会, Jul. 2013, Japanese, 日本周産期・新生児医学会, 横浜, Domestic conference効果的な妊婦CMVスクリーニング法の確立を目指してOral presentation
- The 17th International Conference on Prenatal Diagnosis and Therapy, Jun. 2013, English, INTERNATIONAL SOCIETY FOR PRENATAL DIAGNOSIS, Lisbon, Portugal, International conferenceThe maternal and neonatal outcomes in pregnancies complicated by hyperthyroidism.Poster presentation
- The 17th International Conference on Prenatal Diagnosis and Therapy, Jun. 2013, English, INTERNATIONAL SOCIETY FOR PRENATAL DIAGNOSIS, Lisbon, Portugal, International conferenceLow IgG avidity and ultrasound fetal abnormality predict congenital cytomegalovirus infection.Poster presentation
- The 17th International Conference on Prenatal Diagnosis and Therapy, Jun. 2013, English, INTERNATIONAL SOCIETY FOR PRENATAL DIAGNOSIS, Lisbon, Portugal, International conferenceClinical value of IgG Avidity of pregnant women for the prediction of congenital cytomegalovirus infection.Poster presentation
- The 17th International Conference on Prenatal Diagnosis and Therapy, Jun. 2013, English, INTERNATIONAL SOCIETY FOR PRENATAL DIAGNOSIS, Lisbon, Portugal, International conferenceAwareness of and knowledge about mother-to-child infections in Japanese pregnant women.Poster presentation
- 第65回日本産科婦人科学会学術講演会, May 2013, Japanese, 日本産科婦人科学会, 札幌, Domestic conference免疫グロブリンを用いた先天性サイトメガロウイルス感染に対する胎児感染予防と治療Poster presentation
- 第65回日本産科婦人科学会学術講演会, May 2013, Japanese, 日本産科婦人科学会, 札幌, Domestic conference母体血サイトメガロウイルスlgG avidity測定による先天性感染の発生予知Poster presentation
- 第65回日本産科婦人科学会学術講演会, May 2013, Japanese, 日本産科婦人科学会, 札幌, Domestic conference母子感染に関する妊婦の知識調査Poster presentation
- 第65回日本産科婦人科学会学術講演会, May 2013, Japanese, 日本産科婦人科学会, 札幌, Domestic conference全国妊婦健診施設を対象とした妊婦感染症スクリーニングと先天性感染の実態調査Poster presentation
- 第65回日本産科婦人科学会学術講演会, May 2013, Japanese, 日本産科婦人科学会, 札幌, Domestic conference先天性サイトメガロウイルス感染症に対するバルガンシクロビル療法の効果と副作用Poster presentation
- 第65回日本産科婦人科学会学術講演会, May 2013, Japanese, 日本産科婦人科学会, 札幌, Domestic conference効果的な妊婦CMVスクリーニング法の確立を目指してOral presentation
- 厚生労働科学研究費補助金（生育疾患克服等次世代育成基盤研究事業）, Dec. 2012, Japanese, 東京, Domestic conference母体血サイトメガロウイルスIgG avidity測定による先天性感染の発生予知Oral presentation
- 厚生労働科学研究費補助金（生育疾患克服等次世代育成基盤研究事業）, Dec. 2012, Japanese, 東京, Domestic conference全国産科施設を対象とした妊婦感染症スクリーニングと先天性感染の実態調査：一次アンケートの結果Oral presentation
- 14th International CMV/BetaHerpesvirus Workshop, Oct. 2012, English, San Francisco, serological screening for CMV in pregnant women is not frequently used in Japan., International conferencePrevalence of Serological Screening of Cytomegalovirus Infection for Pregnant Women in Japan: A Nationwide Survey.Oral presentation
- 14th International CMV/BetaHerpesvirus Workshop, Oct. 2012, English, San Francisco, Among pregnant women with positive or borderline tests for CMV IgM, when they have findings of low serum CMV IgG avidity or ultrasound fetal abnormality, the probability of congenital CMV infection may increase., International conferenceLow IgG avidity and ultrasound fetal abnormality predict congenital cytomegalovirus infection.Poster presentation
- 14th International CMV/BetaHerpesvirus Workshop, Oct. 2012, English, San Francisco, The current awareness and knowledge of CMV infection is significantly lower than that of rubella infection in Japanese pregnant women., International conferenceAwareness and Knowledge of CMV Infection in Japanese Pregnant Women.Poster presentation
- 第7回周産期新生児感染症研究会, Sep. 2012, Japanese, 神戸, Domestic conference全国産科施設を対象とした妊婦感染症スクリーニングと先天性感染の実態調査：一次アンケートの結果Oral presentation
- 第7回周産期新生児感染症研究会, Sep. 2012, Japanese, 神戸, Domestic conference効果的な妊婦CMVスクリーニング法の確立を目指してOral presentation
- 第19回ヘルペス感染症フォーラム, Aug. 2012, Japanese, 札幌, Domestic conference全国産科施設を対象とした妊婦感染症スクリーニングと先天性感染の実態調査：一次アンケートの結果Public symposium
- 第19回日本ヘルペス感染症フォーラム, Aug. 2012, Japanese, 札幌, 現在の我が国におけるCMV母子感染に関する知識は、風疹に比して有意に低かった。, Domestic conference先天性サイトメガロウイルス感染についての知識に関する妊婦アンケート調査および啓発活動[Invited]Nominated symposium
- 第36回日本産科婦人科栄養・代謝研究会, Aug. 2012, Japanese, 日本産科婦人科学会, 鹿児島, Domestic conference75ｇＯＧＴＴにおける1点陽性と2点以上陽性ＧＤＭ妊婦の背景と周産期帰結Oral presentation
- 第48回日本周産期・新生児医学会学術集会, Jul. 2012, Japanese, 埼玉, 現在の我が国の妊婦におけるCMV母子感染に関する知識は、風疹に比して有意に低い。, Domestic conference妊婦におけるサイトメガロウイルス母子感染に関する知識レベルOral presentation
- 第48回日本周産期新生児医学会学術集会, Jul. 2012, Japanese, 日本周産期新生児医学会, 大宮, Domestic conference妊娠中の水痘感染により子宮内胎児死亡に至った一例Poster presentation
- 第48回日本周産期新生児医学会学術集会, Jul. 2012, Japanese, 日本周産期新生児医学会, 大宮, Domestic conferenceCMV IgM陽性妊婦における先天性CMV感染の発生予測Poster presentation
- 第48回日本周産期新生児医学会学術集会, Jul. 2012, Japanese, 日本周産期新生児医学会, 大宮, Domestic conference75ｇＯＧＴＴにおける1点陽性と2点以上陽性ＧＤＭ妊婦の背景と周産期帰結Poster presentation
- 第125回近畿産科婦人科学会学術集会, Jun. 2012, Japanese, 近畿産科婦人科学会, 大阪, Domestic conference妊娠中の水痘感染により子宮内胎児死亡に至った一例Oral presentation
- 第125回近畿産科婦人科学会学術集会, Jun. 2012, Japanese, 近畿産科婦人科学会, 大阪, Domestic conference産褥11日目に発症した子癇の1例Oral presentation
- 第86回兵庫県産科婦人科学会学術集会, Jun. 2012, Japanese, 兵庫県産科婦人科学会, 兵庫, Domestic conferenceCMV IgM陽性妊婦における先天性CMV感染の発生予測Oral presentation
- 第64回日本産科婦人科学会学術講演会, Apr. 2012, Japanese, 神戸, PIH,PROMや子宮内感染の予知・予防が児予後改善のために重要である, Domestic conference妊娠29週未満早産児の予後不良に関連する因子Poster presentation
- 第64回日本産科婦人科学会学術講演会, Apr. 2012, Japanese, 日本産科婦人科学会, 神戸, Domestic conference特発性血小板減少性紫斑病Oral presentation
- 第71回日本医学放射線学会, Apr. 2012, Japanese, 横浜, 画像診断について出生前後のエコー・MRI所見、出生後のCT所見を含めて胎児MRIを中心に述べる, Domestic conference先天性サイトメガロウィルス症 胎児MRIを中心にPoster presentation
- 第64回日本産科婦人科学会学術講演会, Apr. 2012, Japanese, 日本産科婦人科学会, 神戸, Domestic conference腎不全合併妊娠の3症例Oral presentation
- 第64回日本産科婦人科学会学術講演会, Apr. 2012, Japanese, 神戸, 医師または教授職や管理職にある助産師の視点からの周産期医療の高度な知識や技術に関する実践的教育は、現場助産師は肯定的に受け入れる可能性が高く、今後の周産期医療における望ましいチーム医療構築への寄与が期待される。, Domestic conference周産期母児管理におけるチーム医療の充実を期した助産師教育プログラム構築の試みPoster presentation
- 第64回日本産科婦人科学会学術講演会, Apr. 2012, Japanese, 日本産科婦人科学会, 神戸, Domestic conference高安病合併妊娠の4症Poster presentation
- 第64回日本産科婦人科学会学術講演会, Apr. 2012, Japanese, 神戸, 新生児一過性甲状腺機能亢進症発症は、病勢が強く、抗甲状腺薬の増量を要する症例に多かった。重篤な産科、新生児合併症の発症はなく、当科での管理は適切と思われた。, Domestic conference甲状腺機能亢進症合併妊娠の帰結と新生児甲状腺機能異常Poster presentation
- Pediatric Academic Societies Annual Meeting, Apr. 2012, English, Boston, Ventricular dilatation is associated with abnormalities of ABR in infants with CCMVI. We suggest that detection of ventricular dilatation in fetus with CCMVI may be an early marker for the development of hearing impairment., International conferenceVentricular dilatation is associated with abnormalities of auditory brainstem response in infants with congenital cytomegalovirus infection.Poster presentation
- 第64回日本産科婦人科学会学術講演会, Apr. 2012, English, 神戸, Renin is elevated in MD twins with a large BW discordance, even in non-TTTS., Domestic conferenceRenin is elevated in monochorionic diamniotic twins who have birthweight discordance but not twin-to-twin transfusion syndromeOral presentation
- 第64回日本産科婦人科学会学術講演会, Apr. 2012, Japanese, 日本産科婦人科学会, 神戸, Domestic conferenceCMV IgM陽性妊婦における先天性CMV感染の発生予測Poster presentation
- 第64回日本産科婦人科学会学術講演会, Apr. 2012, Japanese, 日本産科婦人科学会, 神戸, Domestic conference75ｇＯＧＴＴにおける1点陽性と2点以上陽性ＧＤＭ妊婦の背景と周産期帰結Poster presentation
- 第64回日本産科婦人科学会学術講演会, Apr. 2012, Japanese, 日本産科婦人科学会, 神戸, Domestic conference6回以上流産歴がある治療抵抗性・難治性習慣流産に対する60ｇ免疫グロブリン療法Oral presentation
- 欧州放射線学会議, Mar. 2012, English, 欧州放射線学会, ウイーン, オーストリア, International conferenceImaging of congenital cytomegalovirous infection (CCMVI)Poster presentation
- 日本周産期・新生児医学会 第30回周産期学シンポジウム, Feb. 2012, Japanese, 日本周産期・新生児医学会, 東京, Domestic conference母体及び胎盤臍帯要因で極低出生体重児として出生した重度胎児発育不全児の3歳時の精神運動発達Oral presentation
- 第6回日本血栓止血学会学術標準化委員会シンポジウム, Jan. 2012, Japanese, 日本血栓止血学会, 東京, Domestic conference不育症の治療－特に抗リン脂質抗体陽性女性の妊娠転帰Public symposium
- 厚生労働科学研究費補助金【成育疾患克服等次世代育成基盤研究事業】先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 第2回班会議, Dec. 2011, Japanese, 厚生労働科学研究費補助金 (成育疾患克服等次世代育成基盤研究事業)先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究, 東京, Domestic conference妊婦におけるCMV母子感染に関する知識レベルOral presentation
- 厚生労働科学研究費補助金[成育疾患克服等次世代育成基盤研究事業]先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 第2回班会議, Dec. 2011, Japanese, 厚生労働科学研究費補助金 (成育疾患克服等次世代育成基盤研究事業)先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究, 東京, Domestic conference神戸大学における先天性CMV感染児の臨床像とフォローアップの現況Oral presentation
- 『厚生労働科学研究費補助金 (成育疾患克服等次世代育成基盤研究事業)先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 第2回班会議』, Dec. 2011, Japanese, 厚生労働科学研究費補助金 (成育疾患克服等次世代育成基盤研究事業)先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究, 東京, Domestic conference神戸の妊婦･新生児CMVスクリーニングの進捗状況Oral presentation
- 厚生労働科学研究費補助金 (成育疾患克服等次世代育成基盤研究事業)先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 第2回班会議, Dec. 2011, Japanese, 厚生労働科学研究費補助金 (成育疾患克服等次世代育成基盤研究事業)先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究, 東京, Domestic conferenceCMV IgM陽性妊婦における先天性CMV感染の発生予測Oral presentation
- 第27回日本糖尿病・妊娠学会, Nov. 2011, Japanese, 日本糖尿病・妊娠学会, 神戸, Domestic conference当院における妊娠糖尿病85例の妊娠中の管理および周産期帰結に関する検討Oral presentation
- 第125回近畿産科婦人科学術集会, Nov. 2011, Japanese, 近畿産科婦人科学会, 大阪, Domestic conference当院における妊娠糖尿病85例の妊娠中の管理および周産期帰結に関する検討Oral presentation
- 第32回日本妊娠高血圧学会, Oct. 2011, Japanese, 日本妊娠高血圧学会, 金沢, Domestic conference妊娠28週以下の人工早産におけるPIH症例の検討Oral presentation
- 第2回神戸産婦人科臨床フォーラム, Oct. 2011, Japanese, 神戸産婦人科臨床フォーラム, 神戸, Domestic conference前置・低置胎盤症例に対するサージセルニューユニット子宮内充填の試みOral presentation
- 第32回日本妊娠高血圧学会, Oct. 2011, Japanese, 日本妊娠高血圧学会, 金沢, Domestic conference治療に難渋したループス腎炎合併妊娠の1例Oral presentation
- 第2回神戸産婦人科臨床フォーラム, Oct. 2011, Japanese, 神戸産婦人科臨床フォーラム, 神戸, Domestic conference子宮内膜癌MPA治療後の妊娠で癒着胎盤となった1症例Oral presentation
- 院内助産所・助産師外来開設のための管理者及び助産師研修プログラム, Oct. 2011, Japanese, 院内助産所・助産師外来開設のための管理者及び助産師研修プログラム, 神戸, Domestic conference産科超音波診断の基礎と演習[Invited]Invited oral presentation
- 第2回神戸産婦人科臨床フォーラム, Oct. 2011, Japanese, 神戸産婦人科臨床フォーラム, 神戸, Domestic conference産科画像診断～基礎から応用編まで～Invited oral presentation
- 第2回神戸産婦人科臨床フォーラム, Oct. 2011, Japanese, 神戸産婦人科臨床フォーラム, 神戸, Domestic conference血液透析を行いながら生児を得た妊婦3症例の臨床像Oral presentation
- 第5回周産期新生児感染症研究会, Sep. 2011, Japanese, 周産期新生児感染症研究会, 神戸, Domestic conference妊娠中の水痘初感染により子宮内胎児死亡に至った1例Oral presentation
- JSAWI2012, Sep. 2011, Japanese, JSAWI, 淡路, Domestic conference既往帝王切開子宮創部に発生する産科的トラブルと画像所見Oral presentation
- 第63回日本産科婦人科学会・学術講演会, Aug. 2011, Japanese, 日本産科婦人科学会, 大阪, Domestic conference妊娠中に齲歯から感染性心内膜炎を発症した1 例Poster presentation
- 第63回日本産科婦人科学会・学術講演会, Aug. 2011, Japanese, 日本産科婦人科学会, 大阪, Domestic conference糖尿病合併妊娠および妊娠糖尿病の周産期予後Poster presentation
- 第35回日本産科婦人科栄養・代謝研究会, Aug. 2011, Japanese, 日本産科婦人科栄養・代謝研究会, 東京, Domestic conference当院における妊娠糖尿病80例の妊娠中の管理および周産期帰結に関する検討Oral presentation
- 第63回日本産科婦人科学会・学術講演会, Aug. 2011, Japanese, 日本産科婦人科学会, 大阪, Domestic conference男性化および低リン血症をきたした卵巣腫瘍の1例Poster presentation
- 第63回日本産科婦人科学会・学術講演会, Aug. 2011, Japanese, 日本産科婦人科学会, 大阪, Domestic conference先天性サイトメガロウイルス感染症の5症例Poster presentation
- 第63回日本産科婦人科学会・学術講演会, Aug. 2011, Japanese, 日本産科婦人科学会, 大阪, Domestic conference切迫早産、前期破水（PROM）から28週以下で早産に至った症例の検討Poster presentation
- 第63回日本産科婦人科学会・学術講演会, Aug. 2011, Japanese, 日本産科婦人科学会, 大阪, Domestic conference高血圧合併妊娠42症例の周産期予後に関する後方視的検討Poster presentation
- 第63回日本産科婦人科学会・学術講演会, Aug. 2011, Japanese, 日本産科婦人科学会, 大阪, Domestic conference高安病合併妊娠の2症例Poster presentation
- 第63回日本産科婦人科学会・学術講演会, Aug. 2011, Japanese, 日本産科婦人科学会, 大阪, Domestic conferenceSLE 合併妊娠の転帰Poster presentation
- 第63回日本産科婦人科学会・学術講演会, Aug. 2011, Japanese, 日本産科婦人科学会, 大阪, Domestic conferenceLong VA type の発作性上室性頻拍（PSVT）に対し，母体ソタロール投与が有効であった1例Poster presentation
- 第47回日本周産期・新生児医学会, Jul. 2011, Japanese, 日本周産期・新生児医学会, 札幌, Domestic conference糖尿病合併妊娠56例および妊娠糖尿病72例の周産期帰結に関する検討Oral presentation
- 第47回日本周産期・新生児医学会総会, Jul. 2011, Japanese, 日本周産期・新生児医学会, 札幌, Domestic conference症例性先天性サイトメガロウィルス感染症の胎児治療に関する検討Others
- 第8回免疫グロブリン胎児医療研究会, Jul. 2011, Japanese, 免疫グロブリン胎児医療研究会, 札幌, Domestic conference症候性先天性サイトメガロウイルス感染症の胎児治療に関する検討Oral presentation
- 第51回日本先天異常学会, Jul. 2011, Japanese, 日本先天異常学会, 東京, Domestic conference症候性先天性サイトメガロウイルス感染症の胎児治療に関する検討Others
- 第47回日本周産期・新生児医学会, Jul. 2011, Japanese, 日本周産期・新生児医学会, 札幌, Domestic conference症候性先天性サイトメガロウイルス感染症の胎児治療に関する検討Oral presentation
- 第47回日本周産期・新生児医学会学術集会, Jul. 2011, Japanese, 日本周産期・新生児医学会, 札幌, Domestic conference症候性先天性サイトメガロウイルス感染症に対するバルガンシクロビル治療効果の前方視的検討Oral presentation
- 第47回日本周産期・新生児医学会, Jul. 2011, Japanese, 日本周産期・新生児医学会, 札幌, Domestic conference周産期大量出血に対するinterventional radiologyOral presentation
- 第51回日本先天異常学会学術集会, Jul. 2011, Japanese, 日本先天異常学会, 東京, Domestic conference院内出生した新生児で染色体検査を施行した症例の検討Oral presentation
- 第47回日本周産期・新生児医学会総会, Jul. 2011, Japanese, 日本周産期・新生児医学会, 札幌, Domestic conferenceサイトメガロウィルス妊婦・新生児スクリーニングの前方視的検討Others
- 第47回日本周産期・新生児医学会, Jul. 2011, Japanese, 日本周産期・新生児医学会, 札幌, Domestic conferenceSLE合併妊娠の転帰と抗リン脂質抗体の影響Oral presentation
- 第124回近畿産科婦人科学会総会・学術集会, Jun. 2011, Japanese, 近畿産科婦人科学会, 和歌山, Domestic conference妊娠中肺出血を起こした右肺動脈欠損症合併妊娠の一例Oral presentation
- 第85回兵庫県産科婦人科学会総会・学術集会, Jun. 2011, Japanese, 兵庫県産科婦人科学会総会・学術集会, 神戸, Domestic conference妊娠中に診断され治療に苦慮したループス腎炎の一例Oral presentation
- 第85回兵庫県産科婦人科学会総会・学術集会, Jun. 2011, Japanese, 兵庫県産科婦人科学会総会・学術集会, 神戸, Domestic conference前置癒着胎盤に対し内腸骨occlusion balloonを使用した8例Oral presentation
- 第85回兵庫県産科婦人科学会総会・学術集会, Jun. 2011, Japanese, 兵庫県産科婦人科学会総会・学術集会, 神戸, Domestic conference前置血管の1例Oral presentation
- 第44回兵庫磁気共鳴医学研究会, Jun. 2011, Japanese, 兵庫磁気共鳴医学研究会, 神戸, Domestic conference前置血管の1例Oral presentation
- 第124回近畿産科婦人科学会総会・学術集会, Jun. 2011, Japanese, 近畿産科婦人科学会, 和歌山, Domestic conference出生後に新生児の染色体検査を施行した症例の検討Oral presentation
- 第124回近畿産科婦人科学会総会・学術集会, Jun. 2011, Japanese, 近畿産科婦人科学会, 和歌山, Domestic conference高安病合併妊娠の3症例Oral presentation
- 第23回兵庫県母性衛生学会総会・学術集会, Jun. 2011, Japanese, 兵庫県母性衛生学会総会・学術集会, 神戸, Domestic conferenceサイトメガロウイルス感染における妊婦及び新生児スクリーニングの成果Oral presentation
- 第124回近畿産科婦人科学会総会・学術集会, Jun. 2011, Japanese, 近畿産科婦人科学会, 和歌山, Domestic conferenceLong VA type の発作性上室性頻拍（PSVT）に対し、母体ソタロール投与が有効であった1例Oral presentation
- 第85回兵庫県産科婦人科学会総会・学術集会, Jun. 2011, Japanese, 兵庫県産科婦人科学会総会・学術集会, 神戸, Domestic conferenceHITを発症したATIII欠損症合併妊娠の1例Oral presentation
- the 1st European Conference of Microbiology and Immunology, May 2011, English, European Conference of Microbiology and Immunology, ブタペスト, ハンガリー, International conferenceFetal therapy with use of hyperimmunoglobulin in symptomatic congenital cytomegalovirus infection.Others
- 1st European Conference of Microbiology and Immunology, May 2011, English, European Conference of Microbiology and Immunology, ブダペスト, ハンガリー, International conferenceFetal therapy with use of hyperimmunoglobulin in symptomatic congenital cytomegalovirus infectionOral presentation
- 1st European Conference of Microbiology and Immunology, May 2011, English, European Conference of Microbiology and Immunology, ブダペスト, ハンガリー, International conferenceCytomegalovirus infection screening in mothers and neonatesOral presentation
- 1st European Conference of Microbiology and Immunology, May 2011, English, European Conference of Microbiology and Immunology, ブダペスト, ハンガリー, International conferenceA prospective study of congenital toxoplasmosis screening with use of IgG avidity and multiplex-nested PCR methodsOral presentation
- 「厚生労働科学研究費補助金 (成育疾患克服等次世代育成基盤研究事業)先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 第1回班会議」, Apr. 2011, Japanese, 厚生労働科学研究費補助金 (成育疾患克服等次世代育成基盤研究事業)先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究, 東京, Domestic conference母子感染の意識調査アンケートと教育啓発方法Oral presentation
- ・厚生労働科学研究費補助金 (成育疾患克服等次世代育成基盤研究事業)先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 第1回班会議, Apr. 2011, Japanese, 厚生労働科学研究費補助金 (成育疾患克服等次世代育成基盤研究事業)先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究, 東京, Domestic conference神戸の妊婦・新生児スクリーニングのこれまでの成果Oral presentation
- 厚生労働科学研究費補助金（成育疾患克服等次世代育成基盤研究事業）先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 第1回班会議, Apr. 2011, Japanese, 厚生労働科学研究費補助金 (成育疾患克服等次世代育成基盤研究事業)先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究, 東京, Domestic conference症候性先天性サイトメガロウイルス感染症の胎児治療に関する検討Oral presentation
- -厚生労働科学研究費補助金 (成育疾患克服等次世代育成基盤研究事業)先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 第1回班会議, Apr. 2011, Japanese, 厚生労働科学研究費補助金 (成育疾患克服等次世代育成基盤研究事業)先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究, 東京, Domestic conference症候性先天性サイトメガロウィルス感染症に対するバルガンシクロビル治療効果の前方視的検討Oral presentation
- 平成22年度 周産期医療事例検討会, Mar. 2011, Japanese, 周産期医療事例検討会, 神戸, Domestic conference切迫早産、前期破水(PROM)から28週以下で早産に至った症例の検討Oral presentation
- 第11回関西出生前診療研究会学術集会、第37回臨床細胞分子遺伝研究会, Mar. 2011, Japanese, 関西出生前診療研究会学術集会、臨床細胞分子遺伝研究会, 西宮, Domestic conference習慣流産に対する絨毛染色体検査から判明した転座型13トリソミーと、その原因となった片親ロバートソン型転座保因者についてOral presentation
- 第11回関西出生前診療研究会学術集会、第37回臨床細胞分子遺伝研究会, Mar. 2011, Japanese, 関西出生前診療研究会学術集会、臨床細胞分子遺伝研究会, 西宮, Domestic conference院内出生した新生児で染色体検査を施行した症例の検討Oral presentation
- 第123回近畿産科婦人科学会総会・学術集会, Nov. 2010, Japanese, 近畿産科婦人科学会, 京都, Domestic conference当科で出生した21トリソミー症例の胎児超音波所見に関する検討Oral presentation
- 第31日本妊娠高血圧学会, Oct. 2010, Japanese, 日本妊娠高血圧学会, 東京, 日本, Domestic conference当院における高血圧合併妊娠30症例の周産期予後に関する後方視的検討Oral presentation
- 第31日本妊娠高血圧学会, Oct. 2010, Japanese, 日本妊娠高血圧学会, 東京, 日本, Domestic conference早発型重症妊娠高血圧腎症で術後にHELLP 症候群・産科的DIC・肺水腫・肝梗塞を発症した1例Oral presentation
- 第31日本妊娠高血圧学会, Oct. 2010, Japanese, 日本妊娠高血圧学会, 東京, 日本, Domestic conferenceSLE 合併妊娠の転帰、産科異常とPIHOral presentation
- 日本学術振興会, 科学研究費助成事業, 基盤研究(B), 獨協医科大学, 01 Apr. 2024 - 31 Mar. 2028遺伝子・抗体等の組合せによる周産期重篤合併症予防指標の開発
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2020 - 31 Mar. 2023免疫抑制ネオセルフ化ペプチドワクチンによる膠原病、産科異常治療法の確立MHCクラスII分子と小胞体内のミスフォールド蛋白質の複合体が病因抗原(ネオセルフ抗原)となり、それに対する抗体(抗ネオセルフ抗体 )が自己免疫疾患を引き 起こすという新しい病態論が提唱された。さらにペプチド抗原とMHCクラスII分子の複合体(ネオセルフ化ペプチド)をマ ウスに免疫し、抗ネオセルフ化ペプチド 抗体を産生させると同抗体がT細胞レセプターとペプチド・MHCクラスII分子複合体との結合を阻害し、 多発性硬化症のモデルマウスにおいて疾患発症を抑制す る可能性が示されており、ペプチドワクチンという新しい治療薬として期待される。今回は不育症や産科異常症の原因となる抗リン脂質抗体症候群の新しい治療 薬としてペプチド化β2-グリコプロテインIとMHCクラスII複合体に対する抗体を誘導するペプチドワクチンの開発を目指した。 Balb/cマウスにFulllengthβ2GPIを免疫するとAPSを発症するので( MiriBlanketal.J Autoimmun 1994)、Balb/cマウスにAPSを発症させてAPTTを計測する有意に延長していたためAPTTを判定項目とした。血小板減少について検討したが、凝集により測定値が異常となってしまい評価項目から削除した。Balb/cマウスに、選定した5種類のネオセルフ化ペプチドのそれぞれで免疫し、フローサイトメトリーを用いてそれぞれのマウスにTCR様抗体が産生されたかを確認した。5種類ともTCR様抗体が産生されたことを確認した。特に３種類のペプチドで力価の高いTCR様抗体が産生されたことを確認した。
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2020 - 31 Mar. 20232光子顕微鏡による胎仔ミクログリアが仔の成長発達に及ぼす影響の解明妊娠中の母体の感染症や飢餓、過食などによる様々な胎児へのストレスがその児の自閉症などの発達障害、統合失調症などの精神疾患のリスクを上昇させることが知られています。脳を構成する細胞の一つであるミクログリアという細胞は、胎児期の早い時期に脳に定着して外敵から胎児の脳を守る働きをしていると考えられいます。さらに、ミクログリア細胞は、中枢神経が発達する過程で神経細胞の間の余分な連絡を断ち切ることによって適切な神経回路を作り上げることを可能にしています。本研究では、妊婦マウスがウイルス感染などの炎症や飢餓・過食などのストレスにさらされている状況を人工的に作り出し、2光子顕微鏡という特別な顕微鏡を使って生きた胎児マウスや思春期マウスのミクログリアの動きをリアルタイムに観察することで母体へのストレスが児の脳に及ぼす影響をミクログリアに焦点を当てて解明しようとしています。これまでにウイルス感染が起こった状態を人工的に作り出した妊娠マウスでは、何の処理もしていない正常な妊婦マウスと比べて胎児ミクログリアの動く速さは早くなっていましたが、生後10日目のマウスでは、逆にウイルス感染疑似母親マウスから生まれたマウスで遅くなっていることが分かりました。また、ウイルス感染疑似妊娠マウスではその胎児マウスの神経細胞の突起が正常妊娠マウスの胎児のそれより長く、神経細胞の本体がより小さくなっていいました。これらのことより母親の炎症によるストレスが胎児のミクログリア細胞の動きや形に変化を引き起こすことで神経回路の形成に影響している可能性があることが分かりました。
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2020 - 31 Mar. 2023妊娠初期のプロテインS、プロテインC抗凝固因子の変動と産科異常との関連解析全妊婦対象の前向きコホート研究については、妊娠8-12週の当院妊婦外来に通院中の母体を対象に遊離プロテインS抗原量と活性、Dダイマー、可溶性フィブリンモノマー、総プロテインS抗原量ならびに活性と比活性を測定している。プロテインC系全体の活性を測定する検査キットであるThrombopasについては、販売が終了となったため、約1000件で測定を終了した。順調に症例を集積し、その他の項目については2022年3月31日までに約1400件の検体を採取し、妊娠初期の採血を終了した。採血に際して特に有害事象の発生はなかった。今後、介入なく通常の妊娠経過観察を行い、産科異常の発生状況との関連を調べるため、臨床情報の収集を行って解析を行う。総プロテインS比活性の低下を認めた症例において、本人の同意を得らることはできず、プロテインS遺伝子異常の解析は行えなかった。 妊娠による検査値変動についての研究についても、合併症のない妊婦約50例で上と同様の検査項目を妊娠10週、18週、28週、36週 (±2週) で測定した。産褥1ヶ月での測定は、臨床上の採血の機会がなく実施していない。今後妊娠中のプロテインS値の変動についても解析を行う。当院不育外来に通院中の患者および抗リン脂質抗体が陽性と診断されている妊婦40例についても上と同様の検査項目を測定し、結果に基づく介入なく通常の妊娠 経過観察を行っており、こちらも臨床情報の収集を並行して行っている。 抗プロテインS自己抗体と妊娠予後の関連の解析については、プロテインSの抗体測定系の確立を行っているところである。ドットブロットでPVDF膜に滴下するプロテインSの濃度(量)ならびに反応させるプロテインS低下女性の精製IgGの濃度(量)条件設定を行っており、その条件設定をもとにスロットブロットに移行 する予定にしている。
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2020 - 31 Mar. 2023Development of a mouse model for therapies of pregnancy complications caused by abeta2GPI/MHC class II前方視的研究として、不育症、IUFD、HDP、FGR、34週未満早産の既往や現症を有する女性に対して、同意を得てネオ・セルフ抗体を測定した。観察研究として、ネオ・セルフ抗体陽性の妊娠合併症既往の女性においては、次回妊娠で、無治療、LDA単独療法、LDA＋ヘパリン療法の生児獲得率を比較し治療効果を調べた。 不育症428人、FGR120人、HDP107人、34週以前早産72人、膠原病78人、正期産412人で抗β2GPI/HLA-DR7抗体測定を実施した。抗β2GPI/HLA-DR7抗体の陽性率（陽性≧73.3 U）は、不育症18.9％(81/428)、FGR15.8％(19/120)、HDP14.0％(15/107)、34週以前早産8.3％ (6/107)、膠原病34.6％(27/78)、正期産7.8％（32/412）であった。さらに原因・リスク因子不育症217人中40人（18.4％）で抗β2GPI/HLA-DR7抗体が陽性であった。産科異常、膠原病のない正期産に限定すると、抗体陽性率は6.9％（17/248）であった。 一方、2021年12月までに、不育症女性において抗β2GPI/HLA-DR7抗体陽性判明後の全75妊娠から染色体異常流産7妊娠を除いた68妊娠について解析した。LDAのみの13妊娠では、生産10例（76.9％）、妊娠継続中1例(7.7％)、流産2例(15.4％)であり、LDA+ヘパリン39妊娠では、生産26例（66.7％）、妊娠継続中6例(15.4％)、流産7例(17.9％)であった。一方、治療なし、もしくはステロイドのみ10妊娠（治療なし6妊娠、ステロイドのみ4妊娠）では、生産5例（50％）、妊娠継続中0例(0％)、流産5例(50％)だった。抗β2GPI/HLA-DR7抗体陽性の不育症に対して、LDAやLDA+ヘパリン療法が有効である可能性がある。
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2017 - 31 Mar. 2021HLA class II complex antibody in recurrent pregnancy loss and pregnancy complicationsThe aim of this study was to evaluate association between aβ2GPI/HLA-DR7 complex antibody and recurrent pregnancy loss (RPL), infertility, and pregnancy complications. Fifty-two (22.9%) of 227 women with RPL, 24 (19.8%) of 121 women with unexplained RPL, and 22 (19.3%) of 114 women with APS symptoms but not aPL tested positive for the neo-self antibody. 19% of FGR, 14% of HDP, 8% of premature delivery at 34 or less weeks of gestation, 12% of infertility also tested positive for the antibody. The neo-self antibody may be involved in the pathogenesis of RPL, infertility, as well as pregnancy complications.
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2014 - 31 Mar. 2018This prospective study aimed to investigate whether aB2GPI/HLA-II is associated with recurrent pregnancy loss (RPL). Serum level of aB2GPI/HLA-II as well as common aPL (aCL IgG/IgM, aCLB2GPI IgG and LA) in all subjects were measured. The normal range of serum aB2GPI/HLA-II level was established by using the 99th percentile cutoff point for 100 fertile controls. The median (range) serum levels of aB2GPI/HLA-II in control population was 0 (0-308.2) U, and the normal range of it was determined to be 52.6 U or less.One hundred and eight women with RPL were enrolled from December 2016 to September 2017, and serum levels of aB2GPI/HLA-II in them was found to be median 10.3 (range, 0-1952.0) U. Twenty-three (21%) of the 108 women with RPL tested positive for aB2GPI/HLA-II. Seventeen (74%) of the 23 women tested negative for common aPL. Twelve (52%) of the 23 women had unexplained RPL. A novel antibody against B2GPI/HLA-II complexes may be involved in the pathology of RPL.