Research activity information

• Epidemiology of Intensive Nutritional Interventions and Restraints in Hospitalizations for Anorexia Nervosa: Annual National Trends of the United States

  Hiroyasu Ino, Nancy S. Jecker, Yoshiyuki Takimoto, Eisuke Nakazawa

  ABSTRACT Objective Despite the clinical relevance of enteral and parenteral tube feeding and restraint use in anorexia nervosa (AN), national‐level data on their use have remained limited, particularly for total parenteral nutrition (TPN) and percutaneous endoscopic gastrostomy (PEG). This study systematically characterizes the national prevalence and temporal trends in intensive nutritional interventions, defined as nasogastric tube feeding (NGTF), TPN, and PEG, and physical restraint among hospitalizations for AN in the United States (US). Method We analyzed 66,785 hospitalizations for AN from the 2017 to 2022 National Inpatient Sample using modified Poisson and logistic regression models to estimate prevalence, temporal trends, and associated factors. Subgroup and sensitivity analyses were conducted by age groups, race or ethnicity, and hospital characteristics. Results Intensive nutritional interventions and restraints of any type were used in 6.8% of hospitalizations. The prevalence was 3.8% for NGTF, 1.7% for physical restraint, 1.1% for TPN, and 0.7% for PEG. The overall rate of any intervention increased from 5.8% in 2017 to 8.1% in 2022, with a significant annual increase of 0.43 percentage points ( p  = 0.007), primarily driven by NGTF and restraint. Adult patients with AN showed the highest prevalence of any intervention at 7.2%, mainly due to TPN and PEG. Higher intervention rates were observed in urban teaching hospitals. Discussion This study provides the first national‐level evidence that intensive nutritional interventions and restraints, particularly NGTF and restraint, are increasingly used in US hospitalizations for AN. The lower national estimates compared to single‐center studies likely reflect referral bias, supported by subgroup analysis. Increased use of intensive nutritional interventions and restraints is controversial and underscores the need to consider less intensive or coercive alternatives and clearer clinical ethics guidelines.

  Wiley, Jun. 2026, International Journal of Eating Disorders

  Scientific journal


• Beyond Explanation: Principlism as a Guiding Framework for Clinical Ethics Consultation.

  Nana Arai, Yoshiyuki Takimoto, Eisuke Nakazawa

  Mar. 2026, The American journal of bioethics : AJOB, 26(3) (3), 65 - 67, English, International magazine

  Scientific journal


• Informal coercion towards discharge: The entanglement of formal and informal coercion in social resource introduction.

  Hiroyasu Ino, Akira Akabayashi, Yoshiyuki Takimoto, Eisuke Nakazawa

  2026, International journal of law and psychiatry, 105, 102183 - 102183, English, International magazine

  Scientific journal


• Navigating tensions between scientific advancement and ethical practice in biobanking: a qualitative study in Japan.

  Masanori Oikawa, Yoshiyuki Takimoto

  2026, Frontiers in genetics, 17, 1778587 - 1778587, English, International magazine

  Scientific journal


• Effect of social resources on readmission prevention and the influence of informal coercion in acute schizophrenia: a retrospective quasi-experimental cohort study.

  Hiroyasu Ino, Akira Akabayashi, Yoshiyuki Takimoto, Katsumi Mori, Eisuke Nakazawa

  Nov. 2025, Schizophrenia research, 285, 1 - 10, English, International magazine

  Scientific journal


• Ethical, legal, social, and cultural implications of the non-clinical use of transcranial direct current stimulation (tDCS) in Korea and Japan.

  Sinu Choi, Anita S Jwa, Jiwon Shim, Soojin Kim, Juhee Eom, Yoshiyuki Takimoto, Eisuke Nakazawa, Young-Joon Ryu

  Oct. 2025, Neuroscience research, 219, 104951 - 104951, English, International magazine

  Scientific journal


• Protocol for Returning Results in Brain Science Research Targeting Individuals With Neurodevelopmental Disorders in Japan

  Koji Yano, Akira Yasumura, Yoshiyuki Takimoto

  Feb. 2025, NEUROETHICS, 18(1) (1), English

  Scientific journal


• Disparity in attitudes regarding assisted dying among physicians and the general public in Japan.

  Yoshiyuki Takimoto, Tadanori Nabeshima

  Jan. 2025, BMC medical ethics, 26(1) (1), 7 - 7, English, International magazine

  Scientific journal


• Neuroethics Rounds: Place-Sensitive Approaches for Daily Interfaces of Neuroscience-Neuroethics Ecosystems.

  Hiroyasu Ino, Yoshiyuki Takimoto, Eisuke Nakazawa

  2025, AJOB neuroscience, 16(2) (2), 116 - 118, English, International magazine

  Scientific journal


• Perceptions and moral distress in surplus embryo disposition among Japanese IVF patients: a qualitative study.

  Shizuka Katsuzaki, Yoshiyuki Takimoto, Chikako Morioka, Masahiro Nakayama, Tatsuya Harada, Yoko Urata, Tomonori Ishikawa, Masatoshi Takagi

  2025, Frontiers in reproductive health, 7, 1646340 - 1646340, English, International magazine

  Scientific journal


• Misinformation targeting replicon vaccine recipients: an urgent public health ethical issue.

  Hiroyasu Ino, Yoshiyuki Takimoto, Eisuke Nakazawa

  Nov. 2024, Lancet (London, England), 404(10466) (10466), 1922 - 1923, English, International magazine


• Public Perspectives on Consent for and Governance of Biobanking in Japan.

  Masanori Oikawa, Yoshiyuki Takimoto

  Oct. 2024, Journal of empirical research on human research ethics : JERHRE, 19(4-5) (4-5), 208 - 219, English, International magazine

  Scientific journal


• Cross-cultural differences in prefrontal cortex activity in moral judgment: A functional near-infrared spectroscopy (fNIRS) study based on the CNI model.

  Yachun Qian, Yoshiyuki Takimoto, Akira Yasumura

  May 2024, Behavioural brain research, 465, 114891 - 114891, English, International magazine

  Scientific journal


• Perceptions of Psychosocial and Ethical Issues and the Psychological Characteristics of Donors in the Clinical Setting of Living Kidney Donors: A Qualitative Study.

  Nana Arai, Naoki Yokoyama, Mayumi Hara, Yoshiyuki Takimoto

  BACKGROUND: There are several psychosocial and ethical issues surrounding the decision to be a living kidney donor. The present study aimed to determine the perceptions of psychosocial and ethical issues that living kidney donors may have, and analyze their psychological characteristics. METHODS: Face-to-face semi-structured interviews were conducted with 15 donors. Thematic analysis was then performed to categorize the thematic elements of the transcripts. All procedures were approved by the relevant review board. RESULTS: Four main categories were identified: Awareness of family dynamics, barriers to a proper understanding, contrasting psychological effects of recipient presence in clinical practice, insufficient information explained in informed consent. CONCLUSION: Donors felt that they took on the "role as a care giver" for the recipient and were less aware of themselves as patients. This is a new concept that has not been shown in previous studies. Donors exist within the recipient and family, and the range of their autonomy may go beyond the traditional concept of autonomy and be rooted in relational autonomy. This study suggested that medical treatment in the presence of the recipient promotes the relational autonomy of the donor.

  2024, AJOB empirical bioethics, 15(1) (1), 22 - 32, English, International magazine

  Scientific journal


• Clinical Ethics Consultation in Japan: What does it Mean to have a Functioning Ethics Consultation?

  Noriko Nagao, Yoshiyuki Takimoto

  Jan. 2024, Asian bioethics review, 16(1) (1), 15 - 31, English, International magazine

  Scientific journal


• The Gap in Attitudes Toward Withholding and Withdrawing Life-Sustaining Treatment Between Japanese Physicians and Citizens.

  Yoshiyuki Takimoto, Tadanori Nabeshima

  BACKGROUND: According to some medical ethicists and professional guidelines, there is no ethical difference between withholding and withdrawing life-sustaining treatment. However, medical professionals do not always agree with this notion. Patients and their families may also not regard these decisions as equivalent. Perspectives on life-sustaining treatment potentially differ between cultures and countries. This study compares Japanese physicians' and citizens' attitudes toward hypothetical cases of withholding and withdrawing life-sustaining treatment. METHODS: Ten vignette cases were developed. A web-based questionnaire was administered to 457 citizens and 284 physicians to determine whether they supported withholding or withdrawing treatment. RESULTS: In a case where a patient had an advance directive refusing ventilation, 77% of the physicians and 68% of the citizens chose to withhold treatment. In a case where there was an advance directive but the patient's family requested treatment, 55% of the physicians and 45% of the citizens chose to withhold the ventilator. When a family requested withdrawal of the ventilator but patient wishes were unknown, 19% of the physicians and 48% of the citizens chose to withdraw the ventilator. However, when the patient had also indicated their wishes in writing, 49% of the physicians and 66% of the citizens chose to withdraw treatment. More physicians were prepared to withdraw dialysis (84%) and artificial nutrition (81%) at a patient's request than mechanical ventilation (49%). CONCLUSIONS: A significant proportion of Japanese physicians and citizens were reluctant to withhold or withdraw life-sustaining treatment, even in cases where the patient had indicated their wishes in writing. They were more likely to withhold than withdraw treatment, and more likely to withdraw artificial nutrition than mechanical ventilation. Japanese physicians gave significant weight to family views about treatment but were less likely to agree to withdraw treatment than citizens, indicating a potential source of conflict in clinical settings.

  2024, AJOB empirical bioethics, 15(4) (4), 301 - 311, English, International magazine

  Scientific journal


• Attitudes of the Public Toward Consent for Biobank Research in Japan.

  Masanori Oikawa, Yoshiyuki Takimoto, Akira Akabayashi

  Oct. 2023, Biopreservation and biobanking, 21(5) (5), 518 - 526, English, International magazine

  Scientific journal


• Ethics Guideline Development for Neuroscience Research involving Patients with Mental Illness in Japan.

  Yoshiyuki Takimoto, Akifumi Shimanouchi

  Oct. 2023, Asian bioethics review, 15(4) (4), 365 - 375, English, International magazine

  Scientific journal


• Identifying practical clinical problems in active euthanasia: A systematic literature review of the findings in countries where euthanasia is legal.

  Madoka Kono, Nana Arai, Yoshiyuki Takimoto

  Aug. 2023, Palliative & supportive care, 21(4) (4), 705 - 713, English, International magazine

  Scientific journal


• Clinical ethics problems in psychiatry and the need for clinical ethics consultation in Japan: A cross-sectional study.

  Hiroyuki Sato, Yoshiyuki Takimoto

  Jun. 2023, PCN reports : psychiatry and clinical neurosciences, 2(2) (2), e86, English, International magazine

  Scientific journal


• Exploring cultural and gender differences in moral judgment: A cross-cultural study based on the CNI model.

  Yachun Qian, Yoshiyuki Takimoto, Lu Wang, Akira Yasumura

  May 2023, Current psychology (New Brunswick, N.J.), 87(6) (6), 1 - 11, English, International magazine

  Scientific journal


• Verification of the Japanese Version of Greene’s Moral Dilemma Task’s Validity and Reliability

  Yoshiyuki Takimoto, Akira Yasumura

  Mar. 2023, Psych

  Scientific journal


• Ethical Healthcare Attitudes of Japanese Citizens and Physicians: Patient-Centered or Family-Centered?

  Yoshiyuki Takimoto, Tadanori Nabeshima

  BACKGROUND: In current Western medical ethics, patient-centered medicine is considered the norm. However, the cultural background of collectivism in East Asia often leads to family-centered decision-making. In Japan, prior studies have reported that family-centered decision-making is more likely to be preferred in situations of disease notification and end-of-life decision-making. Nonetheless, there has been a recent shift from collectivism to individualism due to changes in the social structure. Various personal factors have also been reported to influence moral decision-making. Therefore, this study examined whether the current trend in attitudes of healthcare decision-making in Japan is family-centered or patient-centered among the general public and physicians. In addition, the personal factors that influence this tendency were examined. METHODS: Three vignettes on disease notification and two vignettes on decision-making during end-of-life care were created, and 457 members of the public and 284 physicians were asked about their attitudes (behavioral intentions) regarding these vignettes. RESULTS: Approximately, 95% of physicians were patient-centered in explaining the patient's severe medical condition. However, approximately 80% of physicians emphasized the wishes of the family over patient wishes when making life-sustaining decisions. Nearly half the general public emphasized the patient's wishes in the explanation of a severe medical condition and in life-sustaining decisions. In both the public and physician groups, personal factors, particularly the presence or absence of a disease under treatment and prior caregiving experience, influenced ethical attitudes toward medical treatment decisions. CONCLUSIONS: In relatively low-conflict situations, such as the announcement of a patient's medical condition, physicians tended to be patient-centered, while they tended to be family-centered in situations of strong conflict in withholding life-sustaining treatment. The fact that personal factors influenced the family-centered response in situations of strong conflict highlights the importance of not only acquiring knowledge of medical ethics but also learning to fairly apply this knowledge in practice.

  2023, AJOB empirical bioethics, 14(3) (3), 125 - 134, English, International magazine

  Scientific journal


• Should Physicians Be Permitted to Refuse Follow-Up Care to Patients Who Have Received an Organ Transplant Through Organ Trafficking?

  Yoshiyuki Takimoto

  2023, Transplant international : official journal of the European Society for Organ Transplantation, 36, 11529 - 11529, English, International magazine

  Scientific journal


• Practical training using immersive roleplay and an intensive course on clinical ethics consultation in Japan.

  Makoto Udagawa, Yoshiyuki Takimoto

  Nov. 2022, BMC medical ethics, 23(1) (1), 118 - 118, English, International magazine

  Scientific journal


• Indications for involuntary hospitalization for refusal of treatment in severe anorexia nervosa: a survey of physicians and mental health care review board members in Japan.

  Yoshiyuki Takimoto

  Nov. 2022, Journal of eating disorders, 10(1) (1), 176 - 176, English, International magazine

  Scientific journal


• Facts and Recommendations regarding When Medical Institutions Report Potential Abuse to Child Guidance Centers: A Cross-Sectional Study.

  Mio Urade, Misao Fujita, Atsushi Tsuchiya, Katsumi Mori, Eisuke Nakazawa, Yoshiyuki Takimoto, Akira Akabayashi

  Nov. 2022, Pediatric reports, 14(4) (4), 479 - 490, English, International magazine

  Scientific journal


• Report on the Establishment of the Consortium for Hospital Ethics Committees in Japan and the First Collaboration Conference of Hospital Ethics Committees.

  Kei Takeshita, Noriko Nagao, Hiroyuki Kaneda, Yasuhiko Miura, Takanobu Kinjo, Yoshiyuki Takimoto

  Oct. 2022, Asian bioethics review, 14(4) (4), 307 - 316, English, International magazine

  Scientific journal


• Psychosocial and Ethical Behaviors and Attitudes of Health Care Professionals in the Clinical Setting of Living Kidney Donors: A Qualitative Study.

  Nana Arai, Yoshiyuki Takimoto, Eisuke Nakazawa, Takeshi Ishimura, Naoki Yokoyama, Mayumi Hara, Reina Ozeki-Hayashi, Akira Akabayashi

  Sep. 2022, Transplantation proceedings, 54(7) (7), 1750 - 1758, English, International magazine

  Scientific journal


• Disclosing a diagnosis of autism spectrum disorder without intellectual disability to pediatric patients in Japan in early diagnostic stages and associated factors: a cross-sectional study.

  Hiroyuki Sato, Misao Fujita, Atsushi Tsuchiya, Taichi Hatta, Katsumi Mori, Eisuke Nakazawa, Yoshiyuki Takimoto, Akira Akabayashi

  Aug. 2022, BioPsychoSocial medicine, 16(1) (1), 18 - 18, English, International magazine

  Scientific journal


• Should suicide be prevented among cancer patients?

  Yoshiyuki Takimoto

  Aug. 2022, Palliative & supportive care, 20(4) (4), 607 - 608, English, International magazine

  Scientific journal


• Key components of the mental capacity assessment of patients with anorexia nervosa: a study of three countries.

  Yoshiyuki Takimoto

  Jul. 2022, Journal of eating disorders, 10(1) (1), 110 - 110, English, International magazine

  Scientific journal


• International comparison of physicians' attitudes toward refusal of treatment by patients with anorexia nervosa: a case-based vignette study.

  Yoshiyuki Takimoto

  Jun. 2022, Journal of eating disorders, 10(1) (1), 86 - 86, English, International magazine

  Scientific journal


• Neuropeptide regulation by herbal medicine.

  Masahiro Ohsawa, Yoshiyuki Takimoto, Herbert Herzog, Akio Inui

  Jun. 2022, Neuropeptides, 93, 102240 - 102240, English, International magazine


• Stroke Survivors' Experiences and Needs during the Decision-making Process Considering Rehabilitation Options: A Pilot Descriptive Study in Japan.

  Kaori Muraoka, Yoshiyuki Takimoto, Eisuke Nakazawa, Tetsuya Tsuji, Meigen Liu

  2022, Progress in rehabilitation medicine, 7, 20220024 - 20220024, English, Domestic magazine

  Scientific journal


• Application of Kampo medicines for the palliation of cancer cachexia.

  Masahiro Ohsawa, Toshiaki Makino, Yoshiyuki Takimoto, Akio Inui

  Dec. 2021, Neuropeptides, 90, 102188 - 102188, English, International magazine

  Scientific journal


• Medicine and food with particular reference to chinpi, dried citrus peel, and a component of Ninjin'yoeito.

  Mika Sakaki, Kenji Harai, Ryuji Takahashi, Marie Amitani, Haruka Amitani, Yoshiyuki Takimoto, Akio Inui

  Oct. 2021, Neuropeptides, 89, 102166 - 102166, English, International magazine

  Scientific journal


• A clinical course of a patient with anorexia nervosa receiving surgery for superior mesenteric artery syndrome.

  Ken Kurisu, Yukari Yamanaka, Tadahiro Yamazaki, Ryo Yoneda, Makoto Otani, Yoshiyuki Takimoto, Kazuhiro Yoshiuchi

  Jun. 2021, Journal of eating disorders, 9(1) (1), 79 - 79, English, International magazine

  Scientific journal


• [Mental Capacity of Brain Disease].

  Yoshiyuki Takimoto

  The concept of mental capacity refers to the a bility to understand medical explanations and make decisions with reference to values. Evaluating mental capacity is associated with patient autonomy and mental capacity is clinically and ethically important. In competent patients, patient self-determination is respected. On the other hand, in incompetent patients, "best interest" is presumed in terms of medical fact and patient value.

  Jul. 2020, Brain and nerve = Shinkei kenkyu no shinpo, 72(7) (7), 711 - 717, Japanese, Domestic magazine

  Scientific journal


• Characterizing patients issued DNR orders who are ultimately discharged alive: a retrospective observational study in Japan.

  Tomoari Mori, Katsumi Mori, Eisuke Nakazawa, Seiji Bito, Yoshiyuki Takimoto, Akira Akabayashi

  Jun. 2020, BMC palliative care, 19(1) (1), 82 - 82, English, International magazine

  Scientific journal


• Beliefs held by breast surgeons that impact the treatment decision process for advanced breast cancer patients: a qualitative study.

  Reina Ozeki-Hayashi, Misao Fujita, Atsushi Tsuchiya, Taichi Hatta, Eisuke Nakazawa, Yoshiyuki Takimoto, Akira Akabayashi

  2019, Breast cancer (Dove Medical Press), 11, 221 - 229, English, International magazine

  Scientific journal


• THE SOCIALITYAND GENDER EFFECT ON DECISION-MAKING IN MORAL DILEMMA SITUATION

  Yoshiyuki Takimoto, Akira Yasumura, Eisuke Nakazawa

  Oct. 2018, INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE, 25, S37 - S37, English


• Cancer cases in clinical ethics consultations at an advanced treatment hospital in Japan (follow-up report)

  Yukari Yamamoto, Yoshiyuki Takimoto, Shiho Urakawa, Akira Akabayashi

  Aug. 2017, PSYCHO-ONCOLOGY, 26, 146 - 146, English


• Discovery and informing research participants of incidental findings detected in brain magnetic resonance imaging studies: Review and multi-institutional study.

  Kyoko Takashima, Yoshiyuki Takimoto, Eisuke Nakazawa, Yoshinori Hayashi, Atsushi Tsuchiya, Misao Fujita, Akira Akabayashi

  May 2017, Brain and behavior, 7(5) (5), e00676, English, International magazine

  Scientific journal


• ORDINARY CITIZENS' EXPECTATIONS FOR REGENERATIVE MEDICINE AND IPS CELLS RESEARCHES IN JAPAN

  Eisuke Nakazawa, Yoshiyuki Takimoto, Akabayashi Akira

  Nov. 2016, INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE, 23, S181 - S181, English


• The Social Framework Surrounding the Development of Regenerative Medicine in Japan.

  Eisuke Nakazawa, Yoshiyuki Takimoto, Akira Akabayashi

  Jul. 2016, Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees, 25(3) (3), 466 - 71, English, International magazine

  Scientific journal


• Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4.

  Joshua Runtuwene, Kai-Chun Cheng, Akihiro Asakawa, Haruka Amitani, Marie Amitani, Akinori Morinaga, Yoshiyuki Takimoto, Bernabas Harold Ralph Kairupan, Akio Inui

  2016, Drug design, development and therapy, 10, 2193 - 202, English, International magazine

  Scientific journal


• Activation of imidazoline-I3 receptors ameliorates pancreatic damage.

  Yingxiao Li, Kai-Chun Cheng, Akihiro Asakawa, Haruka Amitani, Yoshiyuki Takimoto, Joshua Runtuwene, Akio Inui

  Sep. 2015, Clinical and experimental pharmacology & physiology, 42(9) (9), 964 - 971, English, International magazine

  Scientific journal


• Cancer Cases in Clinical Ethics Consultation

  Yoshiyuki Takimoto, Kazuhiro Yoshiuchi

  Oct. 2014, PSYCHO-ONCOLOGY, 23, 251 - 251, English


• Autonomic dysfunction responses to head-up tilt in anorexia nervosa.

  Yoshiyuki Takimoto, Kazuhiro Yoshiuchi, Tetsuro Ishizawa, Yoshiharu Yamamoto, Akira Akabayashi

  Aug. 2014, Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 24(4) (4), 175 - 81, English, International magazine

  Scientific journal


• Diamine oxidase activity levels in anorexia nervosa.

  Yoshiyuki Takimoto, Kazuhiro Yoshiuchi, Satoshi Shimodaira, Akira Akabayashi

  Mar. 2014, The International journal of eating disorders, 47(2) (2), 203 - 5, English, International magazine

  Scientific journal


• Psychosocial Risk Factors for Depression in Patients With Hematological Malignant Diseases Who Were Going to Receive Hematopoietic Stem Cell Transplantation

  Takeshi Horie, Kazuhiro Yoshiuchi, Yoshiyuki Takimoto, Yasuhito Nannya, Mineo Kurokawa, Akira Akabayashi

  Nov. 2013, PSYCHO-ONCOLOGY, 22, 301 - 301, English


• INFLUENCE OF PSYCHOLOGICAL FACTORS ON CALORIE INTAKE IN NATURAL SETTINGS IN TYPE 2 DIABETES PATIENTS: A 6-MONTH COMPUTERIZED ECOLOGICAL MOMENTARY ASSESSMENT STUDY

  Kazuhiro Yoshiuchi, Shuji Inada, Hiroe Kikuchi, Ken Ohashi, Yoko Iizuka, Yoshiyuki Takimoto, Yoshiharu Yamamoto, Takashi Kadowaki, Akira Akabayashi

  Apr. 2013, PSYCHOSOMATIC MEDICINE, 75(3) (3), A115 - A115, English


• THE PSYCHOLOGICAL IMPACT OF DEATHWATCH ON STAFFS IN JAPANESE FEE-CHARGING NURSING HOMES

  Yoshiyuki Takimoto, Satoru Yoshie, Yoshiuchi Kazuhiro, Akira Akabayashi

  Apr. 2013, PSYCHOSOMATIC MEDICINE, 75(3) (3), A130 - A131, English


• Physician obligation to provide care during disasters: should physicians have been required to go to Fukushima?

  Akira Akabayashi, Yoshiyuki Takimoto, Yoshinori Hayashi

  Nov. 2012, Journal of medical ethics, 38(11) (11), 697 - 8, English, International magazine

  Scientific journal


• Plasma intact fibroblast growth factor 23 levels in women with bulimia nervosa: A cross-sectional pilot study.

  Makoto Otani, Yoshiyuki Takimoto, Junko Moriya, Kazuhiro Yoshiuchi, Akira Akabayashi

  Jun. 2011, BioPsychoSocial medicine, 5, 7 - 7, English, International magazine

  Scientific journal


• Thrombopoietin and thrombocytopenia in anorexia nervosa with severe liver dysfunction.

  Kazuhiro Yoshiuchi, Yoshiyuki Takimoto, Junko Moriya, Shuji Inada, Akira Akabayashi

  Nov. 2010, The International journal of eating disorders, 43(7) (7), 675 - 7, English, International magazine

  Scientific journal


• Lymphoepithelial Thymoma Characterized by Proliferation of Spindle Cells in a Samoyed Dog

  Tomomi Akiyama, Takehito Morita, Yoshiyuki Takimoto, Akinori Shimada

  Sep. 2009, JOURNAL OF VETERINARY MEDICAL SCIENCE, 71(9) (9), 1265 - 1267, English

  Scientific journal


• Comparison of temporal changes in psychological distress after hematopoietic stem cell transplantation among the underlying diseases of Japanese adult patients.

  Wataru Fukuo, Kazuhiro Yoshiuchi, Yoshiyuki Takimoto, Noriyuki Sakamoto, Hiroe Kikuchi, Maki Hachizuka, Shuji Inada, Yasuhito Nannya, Keiki Kumano, Tsuyoshi Takahashi, Mineo Kurokawa, Akira Akabayashi

  Nov. 2008, BioPsychoSocial medicine, 2, 24 - 24, English, International magazine

  Scientific journal


• Panic disorder and locomotor activity.

  Noriyuki Sakamoto, Kazuhiro Yoshiuchi, Hiroe Kikuchi, Yoshiyuki Takimoto, Hisanobu Kaiya, Hiroaki Kumano, Yoshiharu Yamamoto, Akira Akabayashi

  Nov. 2008, BioPsychoSocial medicine, 2, 23 - 23, English, International magazine

  Scientific journal


• Heart rate and blood pressure variability and baroreflex sensitivity in patients with anorexia nervosa.

  Tetsuro Ishizawa, Kazuhiro Yoshiuchi, Yoshiyuki Takimoto, Yoshiharu Yamamoto, Akira Akabayashi

  Jul. 2008, Psychosomatic medicine, 70(6) (6), 695 - 700, English, International magazine

  Scientific journal


• Plasma intact fibroblast growth factor 23 levels in women with anorexia nervosa.

  Makoto Otani, Yoshiyuki Takimoto, Junko Moriya, Kazuhiro Yoshiuchi, Akira Akabayashi

  Apr. 2008, BioPsychoSocial medicine, 2, 10 - 10, English, International magazine

  Scientific journal


• Effect of mood states on QT interval and QT dispersion in eating disorder patients.

  Yoshiyuki Takimoto, Kazuhiro Yoshiuchi, Akira Akabayashi

  Apr. 2008, Psychiatry and clinical neurosciences, 62(2) (2), 185 - 9, English, International magazine

  Scientific journal


• A template for informed consent forms in medical examination and treatment: An intervention study (vol 13, pg PH15, 2007)

  Yoshiyuki Takimoto, Shoichi Maeda, Brian Taylor Slingsby, Kenji Harada, Takahicle Nagase, Hirokazu Nagawa, Ryozo Nagai, Akira Akabayashi

  Oct. 2007, MEDICAL SCIENCE MONITOR, 13(10) (10), LE16 - LE16, English


• A template for informed consent forms in medical examination and treatment: an intervention study.

  Yoshiyuki Takimoto, Shoichi Maeda, Brian Taylor Slingsby, Kenji Harada, Takahide Nagase, Hirokazu Nagawa, Ryozo Nagai, Akira Akabayashi

  Aug. 2007, Medical science monitor : international medical journal of experimental and clinical research, 13(8) (8), PH15-8 - PH18, English, International magazine

  Scientific journal


• Plasma agouti-related protein levels in women with anorexia nervosa.

  Junko Moriya, Yoshiyuki Takimoto, Kazuhiro Yoshiuchi, Tatsuo Shimosawa, Akira Akabayashi

  Oct. 2006, Psychoneuroendocrinology, 31(9) (9), 1057 - 61, English, International magazine

  Scientific journal


• Bulimia nervosa and abnormal cardiac repolarization.

  Yoshiyuki Takimoto, Kazuhiro Yoshiuchi, Hiroaki Kumano, Tomifusa Kuboki

  OBJECTIVE: Eating disorders (ED) are thought to be risk factors for sudden death, and arrhythmias are one of the major causes of sudden death in ED patients. Late potentials (LPs) are a predictor of arrhythmias and can be measured using signal-averaged electrocardiography (SAECG). We examined arryhthmogenicity by LPs in ED patients. METHODS: We performed SAECG on 48 female ED patients [21 with anorexia nervosa (AN) and 27 with bulimia nervosa (BN)] and on 20 healthy women. An LP was judged positive if two or more of the following criteria were fulfilled: QRS duration >120 ms, root-mean-square voltage <20 microV, and a high-frequency, low-amplitude duration >38 ms. We compared the occurrence of LPs among subgroups. RESULTS: Compared with the controls, BN patients with a history of AN had significantly more SAECG abnormalities. CONCLUSIONS: BN patients with a history of AN may be prone to ventricular arrhythmias.

  Jan. 2006, Journal of psychosomatic research, 60(1) (1), 105 - 7, English, International magazine

  Scientific journal


• Conflict of interest: a Japanese perspective.

  Akira Akabayashi, Brian Taylor Slingsby, Yoshiyuki Takimoto

  2005, Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees, 14(3) (3), 277 - 80, English, International magazine

  Scientific journal


• QT interval and QT dispersion in eating disorders.

  Yoshiyuki Takimoto, Kazuhiro Yoshiuchi, Hiroaki Kumano, Gaku Yamanaka, Tadashi Sasaki, Hiroyuki Suematsu, Yuzo Nagakawa, Tomifusa Kuboki

  BACKGROUND: Eating disorders are thought to be risk factors for cardiac sudden death secondary to arrhythmia. Results in previous studies on QT interval and QT dispersion, markers of fatal arrhythmia, have been inconsistent. METHODS: We prospectively examined 179 female eating disorder patients, being over 18 years old and diagnosed according to the DSM-IV criteria between January 1995 and December 2002, and 52 healthy women. Patients with abnormal plasma electrolytes or taking medications that might influence the electrocardiogram (ECG) were excluded from the study. QT intervals were corrected for heart rate using Bazett's formula and the nomogram method, which is more reliable at extremely low heart rates than Bazett's formula. QT dispersion was measured as the difference between the longest and shortest QT intervals. QT intervals and QT dispersion in each patient group were compared with those in the control group. RESULTS: The 164 eligible patients consisted of 43 patients with anorexia nervosa restricting type, 35 with anorexia nervosa binge eating/purging type, 63 with bulimia nervosa purging type, and 23 with bulimia nervosa non-purging type. There was no significant difference in age between eating disorder patients and controls. QT interval and QT dispersion were significantly longer in all eating disorder subtypes than in the control group. QT interval and QT dispersion were significantly correlated with the rate of body weight loss in bulimia nervosa. CONCLUSIONS: QT interval and QT dispersion were prolonged in both anorexia nervosa and bulimia nervosa. Examination of ECG in eating disorder patients without extremely low body weight also appears to be clinically important.

  2004, Psychotherapy and psychosomatics, 73(5) (5), 324 - 8, English, International magazine

  Scientific journal


• Acute intracerebroventricular administration of either carboxyl-terminal or amino-terminal fragments of agouti-related peptide produces a long-term decrease in energy expenditure in rats.

  Kyoko Goto, Akio Inui, Yoshiyuki Takimoto, Hideki Yuzuriha, Akihiro Asakawa, Yoshihiro Kawamura, Hiroki Tsuji, Yukio Takahara, Chie Takeyama, Goro Katsuura, Masato Kasuga

  We investigated if agouti-related peptide (AgRP), an endogenous antagonist of melanocortin receptors (MC3-R and MC4-R), effects energy expenditure in rats. Fragments of the carboxyl-terminal, AgRP (83-132), and the amino-terminals, AgRP (25-51) and AgRP (54-82), were administered intracerebroventricularly (ICV). Food intake, body weight and fat weight changes were measured 5 and/or 24 h after a single ICV injection of the fragments. Oxygen consumption and colonic temperature were measured as indices of energy expenditure, during 3 and 24 h after the ICV injections, respectively. An oral glucose tolerance test was performed 24 h after ICV AgRP (83-132) injection. Binding experiments were performed in HEK-293 cells that over-expressed human MC4-R. AgRP (83-132), but not AgRP (25-51) nor AgRP (54-82), induced a potent and long-lasting increase in the cumulative food intake. Both the carboxyl-terminal and amino-terminal AgRP fragments significantly decreased oxygen consumption and colonic temperature. Despite the absence of hyperphagia and cross-reactivities with MC4-R, AgRP (25-51) and AgRP (54-82) significantly increased body weight and epididymal/mesenteric fat weight. AgRP (83-132) did not affect glucose and insulin responses to the oral glucose tolerance test. AgRP causes a potent and long-lasting decrease in energy expenditure; an effect that is exhibited by carboxyl-terminal fragments and amino-terminal fragments that lack antagonist activity at the MC receptors. This suggests that the amino-terminal region of AgRP plays a regulatory role in energy metabolism.

  Sep. 2003, International journal of molecular medicine, 12(3) (3), 379 - 83, English, International magazine

  Scientific journal


• Orexigenic/anorexigenic signals in bulimia nervosa.

  Yoshiyuki Takimoto, Akio Inui, Hiroaki Kumano, Tomifusa Kuboki

  Bulimia nervosa (BN) and Anorexia Nervosa (AN) are currently classified as eating disorders (ED). Both disorders are the product of complex interaction between physiological and psychological and social processes; they are characterized by abnormal eating behavior. However, patients with BN differ from AN in their nutritional state and response of treatment with serotonin-selective reuptake inhibitor (SSRI) as well as frequency of comorbidity of mood and anxiety disorders. Although biological mechanisms of both BN and AN are largely unknown, excess of both feeding-stimulatory and feeding inhibitory signaling in AN have been indicated. This report reviews data that point to the hypothesis that dysregulation of monoaminergic and new peptidergic circuitry controlling food intake and energy expenditure play a major role in the eating behavior of BN.

  Jun. 2003, Current molecular medicine, 3(4) (4), 349 - 60, English, International magazine

  Scientific journal


• Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice.

  Akihiro Asakawa, Akio Inui, Kyoko Goto, Hideki Yuzuriha, Yoshiyuki Takimoto, Toshio Inui, Goro Katsuura, Masayuki A Fujino, Michael M Meguid, Masato Kasuga

  Neuropeptides in the hypothalamus play a pivotal role in the regulation of energy balance. Agouti-related protein (AGRP), orexin and melanin-concentrating hormone (MCH) have been identified in the hypothalamus as orexigenic peptides. This study was undertaken to investigate the effects of AGRP, orexin and MCH on oxygen consumption. Oxygen consumption was determined by an O2/CO2 metabolism measuring system at 22 degrees C. Mice were kept unrestrained in the chamber without food or water during the light cycle, and the oxygen consumption was measured for 2 h after intra-cerebroventricular (ICV) administration. ICV administered AGRP (1 nmol/mouse) significantly decreased oxygen consumption compared to ACSF-treated controls. Orexin (1 nmol/mouse) significantly increased oxygen consumption, while MCH (1 nmol/mouse) had no significant effect compared to ACSF-treated controls. These results suggest that AGRP, orexin and MCH might have different effects on energy expenditure, thereby regulating appetite and body weight.

  Oct. 2002, International journal of molecular medicine, 10(4) (4), 523 - 5, English, International magazine

  Scientific journal

• 自律的意思決定困難な患者の成人移行支援のあり方に関する提言

  賀藤 均, 石毛 美夏, 石崎 優子, 一ノ瀬 英史, 掛江 直子, 加藤 美穂子, 鬼頭 浩史, 瀧本 禎之, 永瀬 裕朗, 福島 慎吾, 本田 睦子, 増子 孝徳, 宮本 雄策, 望月 葉子, 吉原 一文, 和田 浩, 望月 秀樹, 濱崎 考史, 三井 哲夫, 窪田 満, 日本小児科学会自律的意思決定困難な患者の成人移行支援のあり方を検討するワーキンググループ

  (公社)日本小児科学会, Jul. 2025, 日本小児科学会雑誌, 129(7) (7), 972 - 986, Japanese


• 精神疾患患者の身体合併症治療における臨床倫理の現在地 精神疾患患者の身体合併症治療における倫理的考察と倫理支援

  瀧本 禎之

  (公社)日本精神神経学会, Jun. 2025, 精神神経学雑誌, (2025特別号) (2025特別号), S593 - S593, Japanese


• 知っておきたい・深めたい Close-up 医療現場に活かすためのコンサルテーション入門 臨床倫理におけるコンサルテーション 理学療法の現場での活用

  勝碕 静香, 瀧本 禎之

  (株)医学書院, May 2025, 理学療法ジャーナル, 59(5) (5), 594 - 597, Japanese


• 倫理コンサルテーションの質～よりよい話し合いのために～ 東京大学医学部附属病院における臨床倫理コンサルテーションの実践と質向上への取り組み

  瀧本 禎之

  日本臨床倫理学会, Mar. 2025, 臨床倫理, (13増刊) (13増刊), 59 - 59, Japanese


• ケースから学ぶ臨床倫理推論 総論 推論の方法論と考え方

  瀧本 禎之

  医歯薬出版(株), Feb. 2025, 医学のあゆみ, 292(6) (6), 530 - 533, Japanese


• 臨床倫理推論の枠組み

  瀧本 禎之

  (一社)日本呼吸ケア・リハビリテーション学会, Oct. 2024, 日本呼吸ケア・リハビリテーション学会誌, 34(Suppl.) (Suppl.), 106s - 106s, Japanese


• 臨床倫理の基礎知識 最善の益

  瀧本 禎之

  (NPO)日本口腔科学会, Sep. 2024, 日本口腔科学会雑誌, 73(2) (2), 75 - 75, Japanese


• 在宅医療における自律性

  瀧本 禎之

  (一社)日本在宅医療連合学会, Jul. 2024, 日本在宅医療連合学会大会プログラム・講演抄録集, 6回, 54 - 54, Japanese


• 臨床における倫理的問題のシンプルな考え方 DNAR,AD,ACPの整理と共に

  瀧本 禎之

  (公社)日本皮膚科学会, May 2024, 日本皮膚科学会雑誌, 134(5) (5), 1323 - 1323, Japanese


• The impact of socio-demographic attributes on moral judgment of Japanese population: Based on the dual process theory in moral judgment

  Takimoto Yoshiyuki, Qian Yachun, Yasumura Akira

  Several factors influence people’s ability to make moral judgments. Apart from manipulating experimental conditions, this association can be explored in terms of socio-demographic attributes such as the social status and background of individuals. This study aimed to investigate the impact of marital status, parental status, income level, and the type of work on people's tendency to make moral judgments. This study recruited participants from across Japan, who completed 60 moral dilemma tasks, personal moral dilemmas (22 questions), impersonal moral dilemmas (19 questions), and non-moral dilemmas (19 questions) used in Greene et al. (2001). This study found that marital status, parenthood, annual personal income, and work status only influenced moral judgments during personal moral dilemmas. However, this difference was not observed for impersonal moral dilemmas and non-moral dilemmas. This study suggests that individual socio-demographic attributes affect moral judgments during personal dilemmas since people experiencing them are strongly influenced by emotions. This result also supports the applicability of the dual-process model in Japanese culture.

  Society for Human Environmental Studies, Jun. 2023, Journal of Human Environmental Studies, 21(1) (1), 61 - 68, Japanese


• 摂食障害の臨床倫理を考える 摂食障害診療における臨床倫理的問題

  瀧本 禎之

  日本心身医学会総会ならびに学術講演会事務局, Jun. 2023, 日本心身医学会総会ならびに学術講演会プログラム・抄録集, 64回, 99 - 99, Japanese


• 病院・臨床倫理委員会の過去と現在

  瀧本 禎之

  日本心身医学会総会ならびに学術講演会事務局, Jun. 2023, 日本心身医学会総会ならびに学術講演会プログラム・抄録集, 64回, 132 - 132, Japanese


• 臨床倫理コンサルテーションの現状

  瀧本 禎之

  (公社)日本皮膚科学会, May 2023, 日本皮膚科学会雑誌, 133(5) (5), 1163 - 1163, Japanese


• 臨床倫理専門部署の倫理コンサルテーションの変遷 専従の臨床倫理コンサルタント(医師職)が配置されるまで

  新井 奈々, 瀧本 禎之

  日本臨床倫理学会, Mar. 2023, 臨床倫理, (11増刊) (11増刊), 95 - 95, Japanese


• タイパと深い観察

  瀧本 禎之

  一般社団法人 日本心身医学会, 2023, 心身医学, 63(3) (3), 200 - 201, Japanese


• 小児医療における倫理的問題 意思決定に関わる課題を中心に

  瀧本 禎之

  (一社)日本児童青年精神医学会, Nov. 2022, 児童青年精神医学とその近接領域, 63(5) (5), 657 - 659, Japanese


• 児童青年精神科臨床における倫理的課題についての検討

  瀧本 禎之

  (一社)日本児童青年精神医学会, Nov. 2022, 児童青年精神医学とその近接領域, 63(5) (5), 659 - 661, Japanese


• Difficulties encountered by occupational health nurses in sharing personal health information

  Sasaki Minako, Takimoto Yoshiyuki, Yamamoto Yukari

  Purpose: This study aims to identify the frequency and type of difficulties encountered by occupational health nurses, which occur when they share employees’ personal health information. Methods: A self-administered mail questionnaire survey was conducted from September to October 2017 among 1,793 members of the Nursing Division of the Japanese Society for Occupational Health, and the Japanese Academy of Occupational Health Nursing. Descriptive statistics were calculated and the association with attributes was verified. An open-ended question was analyzed according to the content analysis. Results: The response rate was 23.8% and number of valid respondents was 384 (21.8%). Those who experienced difficulties “often” accounted for 27.6% of the respondents, and those reporting difficulties “sometimes” accounted for 54.9%. The most frequent tasks and situations, which resulted in difficulties involved measures related to mental health, and situations involving working with those who “did not understand the scope of necessity in occupational health activities.” Additionally, the length of employment at the workplace was associated with the probability of experiencing these types of difficulties. Discussion and Conclusion: This study shows that most respondents experienced some difficulties related to sharing employees’ personal health information. In cases where job accommodations were required, ethical difficulties would often arise because of assisting in the fulfillment of safety considerations and group interests, while simultaneously recognizing the necessity to obtain the individual employee’s consent. It was suggested that mutual understanding between occupational health nurses and employers may reduce these difficulties.

  Japan Academy of Occupational Health Nursing, Oct. 2022, Journal of Japan Academy of Occupational Health Nursing, 9(2) (2), 53 - 61, Japanese


• 倫理的ジレンマに対する意思決定 最善の益から

  瀧本 禎之

  (公社)日本リハビリテーション医学会, Oct. 2022, The Japanese Journal of Rehabilitation Medicine, 59(秋季特別号) (秋季特別号), S225 - S225, Japanese


• 医療倫理の臨床実践

  瀧本 禎之

  日本心身医学会総会ならびに学術講演会事務局, Jun. 2022, 日本心身医学会総会ならびに学術講演会プログラム・抄録集, 63回, 127 - 127, Japanese


• The impact of socio-demographic attributes on moral judgment

  Qian Yachun, yasumura akira, takimoto yoshiyuki

  The Japanese Psychological Association, 2022, The Proceedings of the Annual Convention of the Japanese Psychological Association, 86, 2PM-057-PM - 2PM-057-PM, Japanese


• 【リハビリテーションにおける臨床倫理と合理的配慮】脳卒中・神経難病の臨床倫理

  今長谷 尚史, 瀧本 禎之

  (株)医学書院, Jan. 2022, 総合リハビリテーション, 50(1) (1), 25 - 31, Japanese


• 私たちの直面する臨床倫理～子どもの意思決定支援を中心に～ 小児医療における倫理的問題 意思決定に関わる課題を中心に

  瀧本 禎之

  (一社)日本児童青年精神医学会, Nov. 2021, 日本児童青年精神医学会総会抄録集, 62回, 倫理委員会セミナー - 倫理委員会セミナー, Japanese


• COVID-19感染拡大に伴う諸問題の倫理的検討

  瀧本 禎之

  (NPO)日本緩和医療学会, Jun. 2021, Palliative Care Research, 16(Suppl.) (Suppl.), S180 - S180, Japanese


• 臨床における倫理的ジレンマへのアプローチ法

  瀧本 禎之

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S588 - S588, Japanese


• 日本語版FCQ-ED開発の計画

  宮本 せら紀, 山中 結加里, 野原 伸展, 樋田 紫子, 山崎 允宏, 平出 麻衣子, 米田 良, 原島 沙季, 堀江 武, 稲田 修士, 柴山 修, 大谷 真, 瀧本 禎之, 吉内 一浩

  (一社)日本心身医学会, Jan. 2021, 心身医学, 61(1) (1), 83 - 83, Japanese


• COVID-19感染拡大においてみられた問題に対する倫理的応答

  瀧本 禎之

  日本感染看護学会, 2021, 日本感染看護学会学術集会講演集, 21回, 11 - 11, Japanese


• 臨床倫理推論の方法

  瀧本 禎之

  医学図書出版(株), Nov. 2020, 臨床モニター, 31(Suppl.) (Suppl.), 75 - 75, Japanese


• Case Report : Self-monitoring and Autogenic Training Relieved Dyspnea Effectively in a Patient with Interstitial Pneumonia who had been Receiving Home Oxygen Therapy

  Yoshiuchi Kazuhiro, Nohara Nobuhiro, Takimoto Yoshiyuki, Otani Makoto

  Home oxygen therapy (HOT) does not necessarily improve their quality of life of the patients with chronic respiratory disease because most of them suffer from depression, anxiety and other comorbid symptoms derived from their dyspnea. This paper reports the effectiveness of self-monitoring and autogenic training for relieving the patient of his dyspnea, anxiety and irritability with chronic respiratory failure derived from interstitial pneumonia after providing home oxygen therapy and attending pulmonary rehabilitation. Four months treatment substantially mitigated the symptoms of dyspnea, anxiety and irritability and enabled him to live without HOT. Our approach appeared to comprise of the subset of cognitive behavioral therapy (CBT) for chronic obstructive pulmonary disease (COPD), and the clinical course of this case appeared to elucidate the essentials of efficacy of CBT. Our approach is superior to that of CBT with respect to demand for less time and expense. We expect that more and more patients who are in similar conditions have our treatment and should evaluate its efficacy for the patients.

  Japanese Society of Psychosomatic Medicine, Sep. 2020, Japanese Journal of Psychosomatic Medicine, 60(6) (6), 532 - 538, Japanese


• 臨床倫理推論の方法

  瀧本 禎之

  (一社)日本呼吸器外科学会, Aug. 2020, 日本呼吸器外科学会雑誌, 34(3) (3), 第5回医療倫理講習会 - 第5回医療倫理講習会, Japanese


• 【神経倫理ハンドブック】脳神経疾患の判断能力をめぐって

  瀧本 禎之

  (株)医学書院, Jul. 2020, BRAIN and NERVE: 神経研究の進歩, 72(7) (7), 0711 - 0717, Japanese


• 【医療における臨床倫理コンサルテーション】臨床倫理コンサルテーションとは

  瀧本 禎之

  (株)星和書店, Mar. 2020, 精神科治療学, 35(3) (3), 231 - 236, Japanese


• 【医療現場での怒り-どのように評価しどのように対応するべきか】トラブルマネジメントからみる医療安全と怒り

  瀧本 禎之

  (株)医学書院, Nov. 2019, 精神医学, 61(11) (11), 1335 - 1341, Japanese


• 国立大学病院における患者相談担当者研修の取組み

  石井 理恵, 塩崎 英司, 韮澤 尚之, 仲井 精一, 木村 勝弘, 榊原 章人, 小西 竹生, 瀧本 禎之

  (一社)医療の質・安全学会, Nov. 2019, 医療の質・安全学会誌, 14(Suppl.) (Suppl.), 433 - 433, Japanese


• 【呼吸療法における終末期医療の問題点】呼吸療法における終末期医療の臨床倫理的課題

  瀧本 禎之

  (一社)日本呼吸療法医学会, Nov. 2019, 人工呼吸, 36(2) (2), 140 - 143, Japanese


• 緩和ケアにおける安全と自律のジレンマ～患者・家族・医療者自身の思いとジレンマ～ 臨床倫理的観点からみた緩和ケアにおけるジレンマ

  瀧本 禎之

  (NPO)日本緩和医療学会, Jun. 2019, Palliative Care Research, 14(Suppl.) (Suppl.), S125 - S125, Japanese


• 日常診療における医療倫理と臨床倫理

  瀧本 禎之

  (株)協和企画, Apr. 2019, 皮膚病診療, 41(4) (4), 298 - 302, Japanese


• 臨床倫理コンサルテーション

  瀧本 禎之

  日本医学会, Apr. 2019, 日本医学会総会会誌, 30回, 柱2 - 1, Japanese


• 入院治療中に院内学級を利用することにより社会機能の低下を最小限にとどめることができた神経性やせ症の一例

  米田 良, 平出 麻衣子, 布留川 貴也, 原島 沙季, 堀江 武, 松岡 美樹子, 大谷 真, 榧野 真美, 瀧本 禎之, 吉内 一浩

  (一社)日本心身医学会, Mar. 2019, 心身医学, 59(2) (2), 191 - 191, Japanese


• 【心理職も知らないと困る医療現場の常識】医療倫理

  瀧本 禎之

  (株)金剛出版, Nov. 2018, 臨床心理学, 18(6) (6), 652 - 654, Japanese


• 就職・結婚・妊娠を経て過食嘔吐や薬物乱用そして母親との関係が改善した神経性やせ症の1例

  堀江 武, 榧野 真美, 大谷 真, 瀧本 禎之, 吉内 一浩

  (一社)日本心身医学会, Sep. 2018, 心身医学, 58(6) (6), 557 - 557, Japanese


• Ethical, Legal and Social Implications of Output Brain-Computer Interfaces: A Systematic Review

  NAKAZAWA Eisuke, MIWA Eriko, YAMAMOTO Keiichiro, AKABAYASHI Akira, TAKIMOTO Yoshiyuki

  Introduction: Recently, there has been an increasing growth in studies on Brain-Computer Interfacing (BCI) so as to bring this technology into the phase of practical availability. BCI will contribute to a wide range of human activities, ranging from assisting patients with severe motility disturbance to a variety of nonclinical uses like controlling of cargo-loading machines, gaming or silent speech. The influence of this technology will not stop at the level of individual patients and users, who utilize the technology, but include society as a whole. This will necessitate a deliberation of its ethical, legal, and social consequences. However, currently, these deliberations are not organized in a comprehensive manner. The purpose of this article, therefore, is to provide an overview of preceding ELSI discussions on output BCI and to unveil where further explorations are mandated. Methods: The authors analyzed discussions on BCI in the form of published studies by employing a systematic review and thematic analysis. Results: Previous ELSI discussions on BCI can be classified into four main categories: BCI research ethics; BCI’s impact on society; BCI’s possible influences on human nature; and Nature of BCI ethics. Discussion & Conclusion: While the existing discussions have provided sufficient topics of ELSI on BCI, they have yet to set out the framework to formulate arguments on each topic in an organized manner. Especially, we need more profound arguments about the nature of BCI ethics, namely more philosophical discussions on BCI, to fully appreciate the other categories of BCI research ethics, BCI’s impact on society, and BCI’s possible influences on human nature. The arguments go beyond finding topics, which will include an exploration of the methodology of ELSI discussions about BCI, which should enhance further studies.

  Japan Association for Bioethics, Sep. 2018, Bioethics, 28(1) (1), 61 - 74, Japanese


• The current situation of paired kidney exchange in the world and its future perspectives in Japan: Through a systematic review of literatures

  AKABAYASHI Akira, YOSHIDA Tatsumi, YAMAMOTO Keiichiro, TAKIMOTO Yoshiyuki, NAKAZAWA Eisuke

  In living kidney transplantations, some patients are ineligible due to medical incompatibility, or the results of transplantation is not satisfactory. To address these issues, in addition to immunosuppressant drug therapy, patients outside Japan seek another option called paired kidney exchange, where several couples of donors and recipients with a mismatched kidney exchange their kidneys for a more matched one. This way, the exchanges can increase the number of kidney transplantations and improve their outcome. This paper conducts a systematic review of literatures on paired kidney exchange; to achieve comprehensive understandings of its up-to-date worldwide practice and problems including medical, technical and ethical ones. As a result, while paired kidney exchange can be said to have some medical utilities, they have several problems such as inequality of outcomes of the transplantation, organ trafficking, anonymity, socio-psychological compulsion and justification for the participation of matched pairs. Given these findings, this paper then examines the statement on paired kidney exchanges made by the Japanese Society for Transplantation.

  Japan Association for Bioethics, Sep. 2018, Bioethics, 28(1) (1), 87 - 98, Japanese


• 臨床倫理の基本的考え方 日常診療における医療倫理

  瀧本 禎之

  (公社)日本皮膚科学会, May 2018, 日本皮膚科学会雑誌, 128(5) (5), 1049 - 1049, Japanese


• バイオバンクと市民参加 医学研究における「参加」概念に関する文献調査

  及川 正範, 中澤 栄輔, 瀧本 禎之, 赤林 朗

  (公財)生存科学研究所, Mar. 2018, 生存科学, 28(2) (2), 137 - 151, Japanese


• 臨床倫理の実践 診療現場の医療倫理

  瀧本 禎之

  (一社)山口県医師会, Mar. 2018, 山口県医学会誌, (52) (52), 95 - 96, Japanese


• 【臨床に活かす!倫理カンファ】総論 臨床倫理と臨床倫理コンサルテーション

  瀧本 禎之

  (株)新興医学出版社, Jan. 2018, Modern Physician, 38(1) (1), 19 - 22, Japanese


• 【精神科診療・研究に役立つ実践的倫理】精神疾患患者の同意能力をめぐって

  瀧本 禎之

  (株)アークメディア, Jan. 2018, 臨床精神医学, 47(1) (1), 51 - 55, Japanese


• 知能検査の施行が治療方針変更に有用であった神経性過食症患者の一例

  松岡 美樹子, 原島 沙季, 米田 良, 柴山 修, 大谷 真, 堀江 武, 山家 典子, 榧野 真美, 瀧本 禎之, 吉内 一浩

  (一社)日本心身医学会, Nov. 2017, 心身医学, 57(11) (11), 1161 - 1162, Japanese


• 自宅で転倒して50代で大腿骨転子部骨折を来した特定不能の摂食障害患者の一例

  米田 良, 原島 沙季, 荻野 恵, 堀江 武, 大谷 真, 榧野 真美, 瀧本 禎之, 吉内 一浩

  (一社)日本心身医学会, Nov. 2017, 心身医学, 57(11) (11), 1162 - 1162, Japanese


• 神経性やせ症の治療に院内学級を利用した2例

  米田 良, 平出 麻衣子, 宮本 せら紀, 木田 史彦, 原島 沙季, 堀江 武, 松岡 美樹子, 稲田 修士, 大谷 真, 瀧本 禎之, 吉内 一浩

  (NPO)日本心療内科学会, Nov. 2017, 日本心療内科学会誌, 21(4) (4), 161 - 165, Japanese


• 造血幹細胞移植におけるリエゾン活動20年

  宮本 せら紀, 山崎 允宏, 樋田 紫子, 野原 伸展, 平出 麻衣子, 米田 良, 原島 紗季, 堀江 武, 稲田 修士, 大谷 真, 瀧本 禎之, 吉内 一浩

  (NPO)日本心療内科学会, Nov. 2017, 日本心療内科学会誌, 21(別冊) (別冊), 93 - 93, Japanese


• A特定機能病院の患者相談・臨床倫理センターにおける相談対応 法的観点をふまえた対応を要した事例および対応の実態

  山本 由加里, 浦川 史歩, 萩原 偉彦, 瀧本 禎之

  (一社)日本医療・病院管理学会, Sep. 2017, 日本医療・病院管理学会誌, 54(Suppl.) (Suppl.), 99 - 99, Japanese


• SSRIと認知行動療法の併用療法が著効した強迫性障害を主たる病態とした特定不能の摂食障害の一例

  柴山 修, 堀江 武, 樋口 裕二, 石澤 哲郎, 榧野 真美, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Aug. 2017, 心身医学, 57(8) (8), 866 - 867, Japanese


• 入院治療中に著明な浮腫をきたした神経性食欲不振症の一例

  荻野 恵, 石澤 哲郎, 坂本 典之, 榧野 真美, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Aug. 2017, 心身医学, 57(8) (8), 867 - 867, Japanese


• 臨床倫理 臨床現場における倫理的検討方法

  瀧本 禎之

  (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2017, 日本耳鼻咽喉科学会会報, 120(4) (4), 456 - 457, Japanese


• 園芸用ホースを自ら胃挿入して嘔吐する「チューブ吐き」が習慣化したAN-BPの一例

  堀江 武, 石澤 哲郎, 下平 智史, 荒井 直樹, 荻野 恵, 榧野 真美, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Dec. 2016, 心身医学, 56(12) (12), 1258 - 1258, Japanese


• 著明に骨密度が低下し椎体圧迫骨折を来した神経性食思不振症(制限型)の一例

  荻野 恵, 石澤 哲郎, 榧野 真美, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Dec. 2016, 心身医学, 56(12) (12), 1259 - 1259, Japanese


• 摂食障害治療における院内学級の役割の検討

  米田 良, 平出 麻衣子, 宮本 せら紀, 木田 史彦, 原島 沙季, 松岡 美樹子, 稲田 修士, 大谷 真, 瀧本 禎之, 吉内 一浩

  (NPO)日本心療内科学会, Dec. 2016, 日本心療内科学会誌, 20(別冊) (別冊), 100 - 100, Japanese


• ダイナミック・コンセントの倫理的及び社会的課題

  及川 正範, 中澤 栄輔, 瀧本 禎之, 赤林 朗

  医療事故・紛争対応研究会, Nov. 2016, 医療事故・紛争対応研究会誌, 10, 55 - 70, Japanese


• 患者に寄り添う医療 患者相談の進め方

  瀧本 禎之

  (株)メディカルトリビューン, Sep. 2016, 循環plus, 16(12) (12), 10 - 12, Japanese


• A特定機能病院の患者相談・臨床倫理センターにおける相談対応 判断能力にまつわる院内スタッフからの相談内容および対応の分析

  山本 由加里, 浦川 史歩, 萩原 偉彦, 瀧本 禎之

  (一社)日本医療・病院管理学会, Sep. 2016, 日本医療・病院管理学会誌, 53(Suppl.) (Suppl.), 192 - 192, Japanese


• 【終末期の意思決定-アドバンス・ケア・プランニングの実践をめざして-】アドバンス・ケア・プランニング 医療倫理の観点から

  瀧本 禎之

  (株)新興医学出版社, Aug. 2016, Modern Physician, 36(8) (8), 825 - 828, Japanese


• Practice of Clinical Ethics : The Case of Sedative Therapy

  Takimoto Yoshiyuki

  Japanese Society of Psychosomatic Medicine, Jul. 2016, Japanese Journal of Psychosomatic Medicine, 56(7) (7), 748 - 750, Japanese


• 若手が創る新しい心身医学の夜明け 心療内科医としての覚悟

  原島 沙季, 平出 麻衣子, 布留川 貴也, 米田 良, 堀江 武, 稲田 修士, 柴山 修, 大谷 真, 榧野 真美, 瀧本 禎之

  (一社)日本心身医学会, Jun. 2016, 心身医学, 56(6) (6), 565 - 565, Japanese


• 性別違和に摂食障害を合併した2症例

  平出 麻衣子, 原島 沙季, 布留川 貴也, 米田 良, 大谷 真, 榧野 真美, 瀧本 禎之, 吉内 一浩

  (一社)日本心身医学会, Jun. 2016, 心身医学, 56(6) (6), 603 - 603, Japanese


• 患者相談の進め方、医療倫理の考え方と院内での進め方

  瀧本 禎之

  (一社)日本医療安全学会, Mar. 2016, 日本医療安全学会学術総会抄録集, 2回, 153 - 153, Japanese


• Practice of Clinical Ethics : the Case of Palliative Care

  Takimoto Yoshiyuki

  Japanese Society of Psychosomatic Medicine, Feb. 2016, Japanese Journal of Psychosomatic Medicine, 56(2) (2), 165 - 166, Japanese


• Intelligence Scale for a Patient with Bulimia Nervosa and ADHD : A Case Report

  Takimoto Yoshiyuki, Yoshiuchi Kazuhiro, Matsuoka Mikiko, Harashima Saki, Yoneda Ryo, Yamaya Noriko, Horie Takeshi, Kayano Mami, Shibayama Osamu, Otani Makoto

  Background : Recent studies suggested that some patients with eating disorders had clinical features of developmental disorder. Patient : A 32-year-old female patient had about 21-year history of binge eating and vomiting. She was diagnosed as bulimia nervosa and repeated hospitalization for six years. It had been difficult to reduce her symptoms such as binge-eating and vomiting. Therefore, we assessed her cognitive function using Wechsler Adult Intelligence Scale-3rd (WAIS-Ⅲ). The results of WAIS-Ⅲrevealed that full-scale IQ was low average (FIQ=87). and that performance intelligence quotient (PIQ=80) was significantly lower than verbal intellectual intelligence quotient (VIQ=95). Furthermore, her life history showed that she appeared to be inattentive and impulsive frequently. Then, she was diagnosed as attention deficit hyperactivity disorder (ADHD) according to the DSM-5 criteria and WAIS-Ⅲscores. Therefore, atomoxetine 80 mg/day was prescribed to her for ADHD. As a result, symptoms such as attention deficit, binge eating and vomiting were dramatically reduced. Conclusion : Intelligence scale might be helpful for reconsidering diagnosis and treatment in eating disorders if symptom control was difficult for a long duration.

  Japanese Society of Psychosomatic Medicine, Jan. 2016, Japanese Journal of Psychosomatic Medicine, 56(1) (1), 52 - 57, Japanese


• Clinical Ethics : Refusal of Treatment(Clinical Ethics for Psychosomatic Medicine: Its Basics and Applications)

  Takimoto Yoshiyuki

  Japanese Society of Psychosomatic Medicine, Nov. 2015, Japanese Journal of Psychosomatic Medicine, 55(11) (11), 1267 - 1269, Japanese


• 摂食障害症例の初診時における罹患期間と受診医療機関数について

  布留川 貴也, 窪倉 正三, 平出 麻衣子, 小島 舞, 原島 沙季, 米田 良, 堀江 武, 大谷 真, 榧野 真美, 瀧本 禎之, 吉内 一浩

  (NPO)日本心療内科学会, Nov. 2015, 日本心療内科学会誌, 19(別冊) (別冊), 87 - 87, Japanese


• 無条件の肯定的なストロークに気づいたことで脚本からの脱却が容易になった神経性過食症の一例

  柴山 修, 大谷 真, 榧野 真美, 瀧本 禎之, 吉内 一浩

  (NPO)日本心療内科学会, Nov. 2015, 日本心療内科学会誌, 19(別冊) (別冊), 87 - 87, Japanese


• A特定機能病院の患者相談・臨床倫理センターにおける相談対応 患者相談部門スタッフによる意思決定支援の実態と意義

  山本 由加里, 浦川 史歩, 萩原 偉彦, 瀧本 禎之

  (一社)日本医療・病院管理学会, Oct. 2015, 日本医療・病院管理学会誌, 52(Suppl.) (Suppl.), 163 - 163, Japanese


• エシックスの知恵袋(最終回) この鎮静、倫理的に大丈夫でしょうか…

  瀧本 禎之, 金井 良晃, 海津 未希子

  (株)青海社, Sep. 2015, 緩和ケア, 25(5) (5), 440 - 443, Japanese


• Narrative Approach in Clinical Ethics 3(Clinical Ethics for Psychosomatic Medicine: Its Basics and Applications)

  Takimoto Yoshiyuki

  Japanese Society of Psychosomatic Medicine, Aug. 2015, Japanese Journal of Psychosomatic Medicine, 55(8) (8), 975 - 977, Japanese


• エシックスの知恵袋(第5回) 認知症の患者さんに繰り返される肺炎治療…。ほんとうに良いことなのか疑問です…

  瀧本 禎之, 金井 良晃, 海津 未希子

  (株)青海社, Jul. 2015, 緩和ケア, 25(4) (4), 330 - 334, Japanese


• 造血幹細胞移植患者の心理的評価尺度に関するシステマティックレビュー

  原島 沙季, 米田 良, 堀江 武, 山家 典子, 稲田 修士, 大谷 真, 榧野 真美, 瀧本 禎之, 吉内 一浩

  (一社)日本心身医学会, Jun. 2015, 心身医学, 55(6) (6), 753 - 753, Japanese


• 東京大学医学部附属病院心療内科における神経性やせ症入院患者の年齢・体格の傾向

  米田 良, 原島 沙季, 堀江 武, 山家 典子, 柴山 修, 稲田 修士, 大谷 真, 榧野 真美, 瀧本 禎之, 吉内 一浩

  (一社)日本心身医学会, Jun. 2015, 心身医学, 55(6) (6), 758 - 758, Japanese


• ECT適応の展望およびrTMS導入に関するアンケート調査について ECT、rTMSと精神疾患の研究倫理

  中澤 栄輔, 瀧本 禎之

  (公社)日本精神神経学会, Jun. 2015, 精神神経学雑誌, (2015特別) (2015特別), S490 - S490, Japanese


• エシックスの知恵袋(第4回) 体調も気持ちも不安定な終末期の患者さんに、「予測される予後を伝えなくてはいけない」ことに悩んでいます…

  瀧本 禎之, 金井 良晃, 海津 未希子

  (株)青海社, May 2015, 緩和ケア, 25(3) (3), 246 - 251, Japanese


• A Case Report of Eating Disorder Not Otherwise Specified Whose Main Morbidity was Obsessive-Compulsive Disorder and in Which a Combined Therapy of SSRI and Cognitive-Behavioral Therapy Succeeded

  Yoshiuchi Kazuhiro, Shibayama Osamu, Otani Makoto, Ishizawa Tetsuro, Kayano Mami, Horie Takeshi, Takimoto Yoshiyuki, Higuchi Yuji

  The patient was a 19-year-old male. After consulting emergency room for severe abdominal pain and getting relieved by enema in the year X-5, his obsessiveness with defecation became strong and he came to use many purgatives. After he quit his after-school sport-related club activity in the year X-2, he began to skip meals and to lose body weight from BMI 18.1. Since he began to live alone after he entered a university in April in the year X-1, he lost his weight furthermore. He was referred to our department as an eating disorder patient by a practicing internal medicine doctor in May in the year X (BMI 14.1). Because he indicated neither fear for gaining weight nor distorted body images, he was diagnosed as a case of "eating disorder not otherwise specified". Soon after he started to study abroad in an English-speaking country in April in the year X+1, his rhythm of defecation was disordered and his tendency to skip meals became strengthened. Finally at the end of June of the year, his BMI was 12.1 and he came back to Japan to be admitted to our department. Because he was conscious about the significant interference in his daily life due to his excess obsessiveness with defecation, he was diagnosed as a case of obsessive-compulsive disorder (OCD). After starting combined therapy of exposure and response prevention with fluvoxamine, his obsession calmed down gradually and he continued to eat the hospital meal completely. After being discharged, he took a leave of absence from school and lived with his grandmother. He reduced rituals gradually and his BMI exceeded 18.5, and finally at April in the year X+2, he returned to school. He began to live alone again, but no significant interference has occurred. In a case of atypical eating disorder whose obsession is particularly strong, it may be important to suspect OCD proactively.

  Japanese Society of Psychosomatic Medicine, May 2015, Japanese Journal of Psychosomatic Medicine, 55(5) (5), 432 - 438, Japanese


• Narrative Approach in Clinical Ethics 2(Clinical Ethics for Psychosomatic Medicine : Its Basics and Applications)

  Takimoto Yoshiyuki

  Japanese Society of Psychosomatic Medicine, May 2015, Japanese Journal of Psychosomatic Medicine, 55(5) (5), 439 - 441, Japanese


• Narrative Approach in Clinical Ethics(Clinical Ethics for Psychosomatic Medicine: Its Basics and Applications)

  Takimoto Yoshiyuki

  Japanese Society of Psychosomatic Medicine, Mar. 2015, Japanese Journal of Psychosomatic Medicine, 55(3) (3), 269 - 271, Japanese


• エシックスの知恵袋(第3回) 末期患者さんの希望が害をなす医療行為だったら…

  瀧本 禎之, 金井 良晃, 海津 未希子

  (株)青海社, Mar. 2015, 緩和ケア, 25(2) (2), 139 - 143, Japanese


• 【シリーズ・今これからの心理職(1) これだけは知っておきたい医療・保健領域で働く心理職のスタンダード】医療における意思決定 生命倫理とEBMの観点から

  瀧本 禎之

  (株)金剛出版, Jan. 2015, 臨床心理学, 15(1) (1), 30 - 33, Japanese


• エシックスの知恵袋(第2回) 「母には言わないで」という患者さん、決められそうにない奥さん

  瀧本 禎之, 金井 良晃, 海津 未希子

  (株)青海社, Jan. 2015, 緩和ケア, 25(1) (1), 058 - 062, Japanese


• View Ethical Issues from the Perspective of Ethical Principles(Clinical Ethics for Psychosomatic Medicine : Its Basics and Applications)

  Takimoto Yoshiyuki

  Japanese Society of Psychosomatic Medicine, Dec. 2014, Japanese Journal of Psychosomatic Medicine, 54(12) (12), 1124 - 1126, Japanese


• エシックスの知恵袋(第1回) その患者さんの意向、真に受けちゃってもいいのかな?

  瀧本 禎之, 金井 良晃, 海津 未希子

  (株)青海社, Nov. 2014, 緩和ケア, 24(6) (6), 482 - 485, Japanese


• 神経性やせ症の経過中に上腸間膜動脈症候群に伴う心窩部痛等が出現し急性腎不全にまで至った一例

  米田 良, 原島 沙季, 柴山 修, 大谷 真, 榧野 真美, 瀧本 禎之, 吉内 一浩

  (NPO)日本心療内科学会, Nov. 2014, 日本心療内科学会誌, 18(別冊) (別冊), 78 - 78, Japanese


• 東京大学医学部附属病院心療内科における初診外来受診患者の現状

  原島 沙季, 米田 良, 堀江 武, 山家 典子, 稲田 修士, 大谷 真, 榧野 真美, 瀧本 禎之, 吉内 一浩

  (NPO)日本心療内科学会, Nov. 2014, 日本心療内科学会誌, 18(別冊) (別冊), 88 - 88, Japanese


• Practice of Clinical Ethics : Ethical Analysis of Clinical Cases(Clinical Ethics for Psychosomatic Medicine : Its Basics and Applications)

  Takimoto Yoshiyuki

  Japanese Society of Psychosomatic Medicine, Oct. 2014, Japanese Journal of Psychosomatic Medicine, 54(10) (10), 945 - 947, Japanese


• 超高齢化社会における医療資源投入のあり方 特に救急医療について DNAR指示の実証研究を通して、高齢者救急における医療資源の配分の問題を考える

  森 朋有, 尾藤 誠司, 瀧本 禎之

  (一社)日本救急医学会, Aug. 2014, 日本救急医学会雑誌, 25(8) (8), 364 - 364, Japanese


• Practice of Clinical Ethics : Procedural Justice(Clinical Ethics for Psychosomatic Medicine : Its Basic and Applications)

  Takimoto Yoshiyuki

  Japanese Society of Psychosomatic Medicine, Jul. 2014, Japanese Journal of Psychosomatic Medicine, 54(7) (7), 703 - 704, Japanese


• 【臨床倫理・コンプライアンスとPatient First】生命倫理を臨床現場に導入するには何が必要か?何が問題か?

  瀧本 禎之

  (株)ヴァンメディカル, Jun. 2014, 消化器の臨床, 17(3) (3), 201 - 204, Japanese


• 【臨床倫理・コンプライアンスとPatient First】患者・家族へのがん告知をどう行うか[医療倫理学の立場から]

  中澤 栄輔, 瀧本 禎之

  (株)ヴァンメディカル, Jun. 2014, 消化器の臨床, 17(3) (3), 210 - 213, Japanese


• 有料老人ホームにおける看取りの実態とその関連要因 医療体制の充実と看取り率は有意な関連を有しない

  吉江 悟, 瀧本 禎之

  日本老年社会科学会, Jun. 2014, 老年社会科学, 36(2) (2), 211 - 211, Japanese


• 緩和ケア「がん患者に対する心身医学的アプローチ」 症例検討 医療倫理的解説

  瀧本 禎之

  (一社)日本心身医学会, Jun. 2014, 心身医学, 54(6) (6), 560 - 560, Japanese


• 神経性食思不振症患者におけるDiamine Oxidase濃度の検討

  瀧本 禎之, 下平 智史, 吉内 一浩

  (一社)日本心身医学会, Jun. 2014, 心身医学, 54(6) (6), 577 - 577, Japanese


• DPC導入から10年、東京大学心療内科の摂食障害入院診療はどう変わったのか

  荻野 恵, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2014, 心身医学, 54(6) (6), 595 - 595, Japanese


• 摂食障害の有効な治療を目指した、新しい医療ネットワークシステムの試み

  榧野 真美, 森屋 淳子, 山家 典子, 石澤 哲郎, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2014, 心身医学, 54(6) (6), 596 - 596, Japanese


• Practice of Clinical Ethics : Four Principles of Medical Ethics(Clinical Ethics for Psychosomatic Medicine : Its Basic and Applications)

  Takimoto Yoshiyuki

  Japanese Society of Psychosomatic Medicine, Apr. 2014, Japanese Journal of Psychosomatic Medicine, 54(4) (4), 371 - 372, Japanese


• The Nature of Clinical Ethics and Ethical Issues-Basics of Clinical Ethics(Clinical Ethics for Psychosomatic Medicine : its Basics and Applications)

  瀧本 禎之

  Japanese Society of Psychosomatic Medicine, Feb. 2014, Japanese Journal of Psychosomatic Medicine, 54(2) (2), 174 - 176, Japanese


• 心身医学で知っておきたい臨床論理の基礎と実践 臨床倫理の基礎：臨床倫理・倫理的問題とは

  瀧本 禎之

  2014, 心身医学, 54, 86 - 88


• 研究倫理のフロントライン 研究開始「後」の倫理的問題を考える 脳画像研究における偶発的所見への対処法をめぐる議論 研究実施施設および研究参加者対象実態調査

  高島 響子, 藤田 みさお, 土屋 敦, 中澤 栄輔, 土岐 茂, 岡本 泰昌, 山脇 成人, 瀧本 禎之, 赤林 朗

  (一社)日本臨床薬理学会, Nov. 2013, 臨床薬理, 44(Suppl.) (Suppl.), S149 - S149, Japanese


• 内視鏡診療と医療倫理 診療現場における必要なインフォームド・コンセントの確立と医療倫理

  瀧本 禎之

  (一社)日本消化器内視鏡学会, Sep. 2013, Gastroenterological Endoscopy, 55(Suppl.2) (Suppl.2), 2558 - 2558, Japanese


• 本邦における病院患者相談窓口の設置実態と担当者が感じる葛藤

  吉江 悟, 瀧本 禎之, 榊原 章人

  (一社)日本医療・病院管理学会, Aug. 2013, 日本医療・病院管理学会誌, 50(Suppl.) (Suppl.), 226 - 226, Japanese


• 有料老人ホームにおける看取りの実現に関連する要因と、看取りが職員に与える心理的影響

  瀧本 禎之

  東京 : ユニベール財団, Jun. 2013, 豊かな高齢社会の探究 調査研究報告書 / ユニベール財団 編, 21, 1 - 30,巻頭1p, Japanese


• 中級者のための心身医学 臨床倫理の基礎

  瀧本 禎之

  (一社)日本心身医学会, Jun. 2013, 心身医学, 53(6) (6), 536 - 536, Japanese


• がん患者に対する心身医学的アプローチ 医療倫理面より

  瀧本 禎之

  (一社)日本心身医学会, Jun. 2013, 心身医学, 53(6) (6), 543 - 543, Japanese


• 摂食障害外来治療のドロップアウト要因 当事者へのアンケート調査より

  森屋 淳子, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2013, 心身医学, 53(6) (6), 546 - 546, Japanese


• 心療内科領域における法的問題とリスクマネジメント

  石澤 哲郎, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2013, 心身医学, 53(6) (6), 560 - 560, Japanese


• サイコオンコロジー サイコオンコロジーにおける臨床倫理

  瀧本 禎之

  (一社)日本心身医学会, May 2013, 心身医学, 53(5) (5), 392 - 396, Japanese


• Clinical Ethics in Psycho-oncology(Phychosomatic Medicine Course/Psycho-oncology)

  Takimoto Yoshiyuki

  In daily psycho-oncology clinical situations, healthcare professionals face not only pure medical problems but also ethical problems. Therefore, healthcare professionals engaged in clinical practice of psycho-oncology have to get acquainted with clinical ethics review methods. Major of clinical ethics review methods consists of procedure-based and principle-based approach. Examples of procedure-based and principle-based approach are Jonsen's 4-BOX method and four basic principles of medical ethics, respectively. Definite process in clinical ethics review about each individual case is achieved by means of them.

  Japanese Society of Psychosomatic Medicine, 2013, Japanese Journal of Psychosomatic Medicine, 53(5) (5), 392 - 396, Japanese


• 臨床倫理の基礎

  瀧本 禎之

  (NPO)日本心療内科学会, Nov. 2012, 日本心療内科学会誌, 16(抄録号) (抄録号), 107 - 107, Japanese


• A特定機能病院患者相談・臨床倫理センターにおける「医療従事者への支援」の意義と課題

  榊原 章人, 瀧本 禎之

  (一社)日本医療・病院管理学会, Sep. 2012, 日本医療・病院管理学会誌, 49(Suppl.) (Suppl.), 210 - 210, Japanese


• 経過中に急性心不全を起こした神経性食欲不振症の一例

  太田 美保, 森屋 淳子, 冨田 裕一郎, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jul. 2012, 心身医学, 52(7) (7), 666 - 666, Japanese


• 海外から日本への移住という環境の変化を契機に発症した肥満症の一例

  宮崎 史歩, 稲田 修士, 岩部 真人, 山内 敏正, 門脇 孝, 冨田 裕一郎, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jul. 2012, 心身医学, 52(7) (7), 672 - 672, Japanese


• 携帯情報端末を用いた2型糖尿病に対するセルフケアシステムの開発

  稲田 修士, 吾妻 愛子, 菊地 裕絵, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2012, 心身医学, 52(6) (6), 527 - 527, Japanese


• 頻脈性不整脈(心身症)を契機に不安障害を発症した一例

  宮脇 佳世, 原田 朋子, 太田 美保, 冨田 裕一郎, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2012, 心身医学, 52(6) (6), 547 - 547, Japanese


• 神経性食欲不振症患者における日常生活下での客観的な過活動の評価

  下平 智史, 冨久尾 航, 菊地 裕絵, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2012, 心身医学, 52(6) (6), 573 - 573, Japanese


• 高度肥満症患者の社会的・心理的背景 どうとらえ、どういかすか 重症肥満症への行動医学的アプローチ

  吉内 一浩, 稲田 修士, 瀧本 禎之, 赤林 朗

  日本肥満症治療学会, Jun. 2012, 日本肥満症治療学会学術集会プログラム・抄録集, 30回, 33 - 33, Japanese


• 社会の連携を目指す循環器診療 社会復帰、リハビリテーションの現状と効用 心疾患患者のメンタルケアとリハビリテーション

  瀧本 禎之

  (公財)日本心臓財団, Apr. 2012, 心臓, 44(4) (4), 519 - 521, Japanese


• 臨床倫理コンサルテーション[最終回] 臨床倫理コンサルテーション体制の構築

  瀧本 禎之

  (株)医学書院, Mar. 2012, 病院, 71(3) (3), 222 - 223, Japanese


• 臨床倫理コンサルテーション 臨床倫理コンサルテーションの方法 分析・検討(5)

  瀧本 禎之

  (株)医学書院, Feb. 2012, 病院, 71(2) (2), 150 - 153, Japanese


• 臨床倫理コンサルテーション 臨床倫理コンサルテーションの方法 分析・検討(4)

  瀧本 禎之

  (株)医学書院, Jan. 2012, 病院, 71(1) (1), 64 - 66, Japanese


• NST全体回診によって患者の栄養ルートの選択肢が増えた症例

  北久保 佳織, 辻村 直樹, 澤田 実佳, 冨樫 仁美, 田中 みずき, 堀合 晴美, 小林 智明, 小川 雅子, 花房 規男, 瀧本 禎之, 畑尾 史彦, 関根 里恵, 深柄 和彦

  (株)ジェフコーポレーション, Jan. 2012, 静脈経腸栄養, 27(1) (1), 312 - 312, Japanese


• 臨床倫理コンサルテーション 臨床倫理コンサルテーションの方法 分析・検討(3)

  瀧本 禎之

  (株)医学書院, Dec. 2011, 病院, 70(12) (12), 964 - 966, Japanese


• 臨床倫理コンサルテーション 臨床倫理コンサルテーションの方法 分析・検討(2)

  瀧本 禎之

  (株)医学書院, Nov. 2011, 病院, 70(11) (11), 874 - 876, Japanese


• 著明な低体重にも関わらず自然妊娠・正常分娩をした神経性食欲不振症の一例

  宮脇 佳世, 吾妻 愛子, 太田 美保, 山家 典子, 冨田 裕一郎, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (NPO)日本心療内科学会, Nov. 2011, 日本心療内科学会誌, 15(抄録号) (抄録号), 106 - 106, Japanese


• 臨床倫理コンサルテーション 臨床倫理コンサルテーションの方法 分析・検討(1)

  瀧本 禎之

  (株)医学書院, Oct. 2011, 病院, 70(10) (10), 790 - 791, Japanese


• 臨床倫理コンサルテーション 臨床倫理コンサルテーションの方法 ケースコンサルテーションの手順

  瀧本 禎之

  (株)医学書院, Sep. 2011, 病院, 70(9) (9), 692 - 693, Japanese


• 神経性食欲不振症の経過中に上腸間膜動脈症候群が疑われた1例

  柴山 修, 下平 智史, 森屋 淳子, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Sep. 2011, 心身医学, 51(9) (9), 848 - 848, Japanese


• 臨床倫理コンサルテーション 臨床倫理コンサルテーションの方法 形式とアプローチ

  瀧本 禎之

  (株)医学書院, Aug. 2011, 病院, 70(8) (8), 614 - 615, Japanese


• 臨床倫理コンサルテーション(3)東京大学医学部附属病院の取り組み

  瀧本 禎之

  (株)医学書院, Jul. 2011, 病院, 70(7) (7), 534 - 536, Japanese


• A特定機能病院における院内での暴言暴力への対応

  榊原 章人, 瀧本 禎之

  (一社)日本医療・病院管理学会, Jul. 2011, 日本医療・病院管理学会誌, 48(Suppl.) (Suppl.), 179 - 179, Japanese


• 胃内バルーン留置療法の候補者となった高度肥満症患者における東大式エゴグラムの特徴

  稲田 修士, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2011, 心身医学, 51(6) (6), 536 - 536, Japanese


• 造血幹細胞移植における移植前の心理社会的因子と予後との関連

  宮崎 信行, 八塚 麻紀, 稲田 修士, 下平 智史, 橋本 昌幸, 冨田 裕一郎, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2011, 心身医学, 51(6) (6), 541 - 541, Japanese


• DPC導入による摂食障害入院診療への影響

  瀧本 禎之, 冨田 裕一郎, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2011, 心身医学, 51(6) (6), 549 - 549, Japanese


• 排出行動として下剤を最大450錠/日服用していた神経性食欲不振症の一例

  下平 智史, 宮脇 佳代, 山家 典子, 冨田 裕一郎, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2011, 心身医学, 51(6) (6), 575 - 575, Japanese


• 臨床倫理コンサルテーション 日本における倫理支援体制

  瀧本 禎之

  (株)医学書院, Jun. 2011, 病院, 70(6) (6), 460 - 461, Japanese


• 肥満症治療のチーム医療 高度肥満症に対する胃内バルーン留置を中心としたチーム医療 効果と限界

  畑尾 史彦, 和田 由美恵, 小川 雅子, 清水 伸幸, 羽田 裕亮, 山内 敏正, 吉内 一浩, 稲田 修士, 瀧本 禎之, 植木 浩二郎, 関根 里恵, 門脇 孝, 瀬戸 泰之

  日本肥満症治療学会, Jun. 2011, 日本肥満症治療学会学術集会プログラム・抄録集, 29回, 52 - 52, Japanese


• バルーン療法の候補者となった高度肥満症患者におけるストレス対処の特徴

  稲田 修士, 瀧本 禎之, 吉内 一浩, 畑尾 史彦, 羽田 裕亮, 岡畑 純江, 山内 敏正, 植木 浩二郎, 門脇 孝, 赤林 朗

  日本肥満症治療学会, Jun. 2011, 日本肥満症治療学会学術集会プログラム・抄録集, 29回, 97 - 97, Japanese


• 臨床倫理コンサルテーション 医療機関における倫理支援体制

  瀧本 禎之

  (株)医学書院, May 2011, 病院, 70(5) (5), 369 - 371, Japanese


• 強い不安の訴えに対する心理的サポートが有効であった悪性腫瘍の1例 緩和ケアにおいてがん患者の訴える不安について

  冨田 裕一郎, 福井 三恵子, 海津 未希子, 坂田 尚子, 瀧本 禎之, 吉内 一浩, 赤林 朗

  日本不安症学会, Feb. 2011, 不安障害研究, 3(1) (1), 133 - 133, Japanese


• O1-E-15 造血幹細胞移植における移植前の心理社会的因子と予後との関連(末期医療・悪性腫瘍他,一般口演,今,心身医学に求められるもの-基礎から臨床まで-,第52回日本心身医学会総会ならびに学術講演会)

  下平 智史, 橋本 昌幸, 冨田 裕一郎, 瀧本 禎之, 吉内 一浩, 稲田 修士, 赤林 朗, 八塚 麻紀, 宮崎 信行

  一般社団法人 日本心身医学会, 2011, 心身医学, 51(6) (6), 541, Japanese


• 連載:臨床倫理コンサルテーション(3)

  瀧本 禎之

  2011, 病院, 70(7), 534 - 536


• 連載:臨床倫理コンサルテーション(11)

  瀧本 禎之

  2011, 病院, 71(3), 222 - 223


• 【患者相談・クレーム対応の質向上をめざして 組織体制から考える院内コミュニケーション】実効性のある患者相談対策に向けたシステムづくり 東京大学医学部附属病院患者相談・臨床倫理センターの活動

  赤林 朗, 瀧本 禎之, 阿部 篤子, 上野 仁子

  (株)医学書院, Nov. 2010, 看護管理, 20(12) (12), 1050 - 1055, Japanese


• 院内アンケート調査に基づく「文書によるインフォームド・コンセント取得が必要な範囲」についてのガイドライン策定

  原田 賢治, 赤林 朗, 瀧本 禎之, 中島 勧, 児玉 安司

  (一社)医療の質・安全学会, Nov. 2010, 医療の質・安全学会誌, 5(Suppl.) (Suppl.), 197 - 197, Japanese


• 医療スタッフと家族の心のケア リエゾンという枠組みによる医療スタッフの心のケア

  吉内 一浩, 冨田 裕一郎, 瀧本 禎之, 赤林 朗

  (NPO)日本心療内科学会, Nov. 2010, 日本心療内科学会誌, 14(抄録号) (抄録号), 52 - 52, Japanese


• 神経性大食症患者における血中FGF23濃度

  下平 智史, 大谷 真, 瀧本 禎之, 森屋 淳子, 吉内 一浩, 赤林 朗

  (NPO)日本心療内科学会, Nov. 2010, 日本心療内科学会誌, 14(抄録号) (抄録号), 75 - 75, Japanese


• A特定機能病院における苦情対応 累積対応回数別の内容・対応の特徴

  吉江 悟, 阿部 篤子, 榊原 章人, 萩原 偉彦, 瀧本 禎之, 前田 正一, 赤林 朗

  (一社)日本医療・病院管理学会, Sep. 2010, 日本医療・病院管理学会誌, 47(Suppl.) (Suppl.), 165 - 165, Japanese


• 肥満症治療の最先端と未来像 高度肥満症治療における連携と統合のアプローチ 心療内科からのアプローチ

  瀧本 禎之, 稲田 修士, 吉内 一浩, 赤林 朗

  日本肥満症治療学会, Sep. 2010, 日本肥満症治療学会学術集会プログラム・抄録集, 3回, 44 - 44, Japanese


• 肥満症治療へのチーム医療の構築 チーム医療における心療内科医の役割

  吉内 一浩, 稲田 修士, 瀧本 禎之, 赤林 朗

  日本肥満症治療学会, Sep. 2010, 日本肥満症治療学会学術集会プログラム・抄録集, 3回, 51 - 51, Japanese


• バルーン療法の候補者となった高度肥満症患者における東大式エゴグラムの特徴

  稲田 修士, 瀧本 禎之, 吉内 一浩, 畑尾 史彦, 羽田 裕亮, 岡畑 純江, 山内 敏正, 門脇 孝, 赤林 朗

  日本肥満症治療学会, Sep. 2010, 日本肥満症治療学会学術集会プログラム・抄録集, 3回, 123 - 123, Japanese


• 造血幹細胞移植予定患者におけるセルフエスティームと気分との関連

  宮崎 信行, 八塚 麻紀, 稲田 修士, 下平 智史, 冨田 裕一郎, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2010, 心身医学, 50(6) (6), 550 - 550, Japanese


• コンサルテーション活動におけるがんの患者不安・抑うつ

  橋本 昌幸, 冨田 裕一郎, 瀧本 禎之, 吉内 一浩, 赤林 朗

  日本不安症学会, Mar. 2010, 不安障害研究, 2(1) (1), 183 - 183, Japanese


• 【一般内科外来を訪れる精神疾患へのアプローチ】プライマリケアとしての精神疾患の実地診療の基本 内科外来での心身症のとらえかたと内科疾患への応用

  大谷 真, 瀧本 禎之

  (株)文光堂, Sep. 2009, Medical Practice, 26(9) (9), 1450 - 1455, Japanese


• A特定機能病院の患者相談・臨床倫理センターにおける相談対応(第1報) 2008年度対応実績より

  榊原 章人, 阿部 篤子, 萩原 偉彦, 吉江 悟, 瀧本 禎之, 前田 正一, 赤林 朗

  (一社)日本医療・病院管理学会, Sep. 2009, 日本医療・病院管理学会誌, 46(Suppl.) (Suppl.), 254 - 254, Japanese


• A特定機能病院の患者相談・臨床倫理センターにおける相談対応(第2報) 患者相談部門スタッフによる診療場面等への「同席」の意義と課題

  吉江 悟, 瀧本 禎之, 阿部 篤子, 榊原 章人, 萩原 偉彦, 前田 正一, 赤林 朗

  (一社)日本医療・病院管理学会, Sep. 2009, 日本医療・病院管理学会誌, 46(Suppl.) (Suppl.), 255 - 255, Japanese


• 栄養状態改善に伴い重篤な合併症から回復した神経性食欲不振症(制限型)の1例

  八塚 麻紀, 稲田 修一, 宮崎 信行, 瀧本 禎之, 吉内 一浩, 熊野 宏昭, 赤林 朗

  (一社)日本心身医学会, Aug. 2009, 心身医学, 49(8) (8), 936 - 936, Japanese


• 肥満患者に対するリエゾン活動の取り組み(第1報)

  稲田 修士, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Aug. 2009, 心身医学, 49(8) (8), 936 - 937, Japanese


• 治療中に発症した適応障害患者に対し薬物療法から非薬物療法への移行が成功した1例

  伊藤 牧子, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Aug. 2009, 心身医学, 49(8) (8), 937 - 937, Japanese


• 東大病院における肥満症に対する集学的治療への心療内科の関わり

  稲田 修士, 瀧本 禎之, 吉内 一浩, 畑尾 史彦, 羽田 裕亮, 岡畑 純江, 山内 敏正, 門脇 孝, 赤林 朗

  日本肥満症治療学会, Jul. 2009, 日本肥満症治療学会学術集会プログラム・抄録集, 2回, 106 - 106, Japanese


• 自己誘発性嘔吐から摂食障害が疑われた、腸回転異常の1例

  下平 智史, 宮崎 信行, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2009, 心身医学, 49(6) (6), 559 - 559, Japanese


• 神経性食欲不振症患者の入院加療における自律神経機能と安静時基礎代謝量の変化

  森屋 淳子, 瀧本 禎之, 吉内 一浩, 早野 順一郎, 赤林 朗

  (一社)日本心身医学会, Jun. 2009, 心身医学, 49(6) (6), 690 - 690, Japanese


• The Education and Training Programs at the Department of Psychosomatic Medicine, The University of Tokyo Hospital(An Introduction to a Course Model of Education and Training in Psychosomatic Medicine)

  Yoshiuchi Kazuhiro

  Japanese Society of Psychosomatic Medicine, Apr. 2009, Japanese Journal of Psychosomatic Medicine, 49(4) (4), 325 - 332, Japanese


• EMAを応用したパニック障害患者の身体活動度評価 パニック発作と身体活動度の関係について

  坂本 典之, 吉内 一浩, 菊地 裕絵, 瀧本 禎之, 貝谷 久宣, 熊野 宏昭, 山本 義春, 赤林 朗

  日本不安症学会, Mar. 2009, 不安障害研究, 1(1) (1), 294 - 295, Japanese


• 外来でみるやせと摂食障害

  冨田 裕一郎, 瀧本 禎之

  (株)日本医事新報社, Feb. 2009, 日本医事新報, (4427) (4427), 110 - 111, Japanese


• 【緩和医療・終末期医療における倫理と法】終末期医療領域のわが国のガイドラインのレビュー

  瀧本 禎之

  (株)先端医学社, Jan. 2009, 緩和医療学, 11(1) (1), 3 - 11, Japanese


• 【ストレス関連疾患 患者背景にある、隠れたストレスを見過ごしていませんか?】基礎編 プライマリ・ケアにおける医療倫理

  瀧本 禎之, 赤林 朗

  (株)南山堂, Jan. 2009, 治療, 91(1) (1), 28 - 31, Japanese


• NST介入期間と効果の関連

  関根 里恵, 永友 利津子, 林 実佳, 吉野 愛美, 鷲尾 智子, 白石 憲史郎, 畑尾 史彦, 二藤 隆春, 野村 和至, 瀧本 禎之, 花房 規男, 山口 浩和, 大谷 幸子

  (株)ジェフコーポレーション, Jan. 2009, 静脈経腸栄養, 24(1) (1), 338 - 338, Japanese


• 閉経後女性うつ病患者における血液中アンドロゲン・エストロゲン濃度と骨代謝マーカー

  大谷 真, 熊野 宏昭, 吉田 菜穂子, 森屋 淳子, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (NPO)日本心療内科学会, Nov. 2008, 日本心療内科学会誌, 12(抄録号) (抄録号), 83 - 83, Japanese


• Clinical ethics in rehabilitation.

  瀧本 禎之, 赤林 朗

  (株)医学書院, Jun. 2008, 総合リハビリテーション, 36(6) (6), 561 - 566, Japanese


• The role of agouti-related protein in energy homeostasis

  森屋 淳子, 瀧本 禎之, 赤林 朗

  (公財)金原一郎記念医学医療振興財団, Jun. 2008, 生体の科学, 59(3) (3), 232 - 237, Japanese


• 神経性食欲不振症女性の経過中に急激な尿酸値の低下が痛風発作を誘発した一例

  宮崎 信行, 石澤 哲郎, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2008, 心身医学, 48(6) (6), 520 - 520, Japanese


• 神経性食欲不振症患者の行動療法におけるAGRP、leptin、REEの変化

  森屋 淳子, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2008, 心身医学, 48(6) (6), 521 - 521, Japanese


• 肥満患者に対する集学的治療における心療内科の関わり

  稲田 修士, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2008, 心身医学, 48(6) (6), 533 - 533, Japanese


• 急性肝障害・血小板減少・PT延長を呈した神経性食欲不振症(制限型)の1例

  八塚 麻紀, 鈴木 亜紀, 宮崎 信行, 瀧本 禎之, 吉内 一浩, 熊野 宏昭, 赤林 朗

  (一社)日本心身医学会, May 2008, 心身医学, 48(5) (5), 378 - 379, Japanese


• 神経性食欲不振症の治療経過中に感染性心内膜炎を合併した1例

  宮崎 信行, 鈴木 亜紀, 瀧本 禎之, 吉内 一浩, 熊野 宏昭, 赤林 朗

  (一社)日本心身医学会, May 2008, 心身医学, 48(5) (5), 379 - 379, Japanese


• 【肥満症の治療の新しい局面】肥満症の行動療法 認知行動療法

  稲田 修士, 瀧本 禎之, 吉内 一浩

  (有)科学評論社, May 2008, 内分泌・糖尿病科, 26(5) (5), 451 - 456, Japanese


• 【軽症うつ病 プライマリケア医に課せられた対応】日常診療におけるうつ病 薬剤性

  瀧本 禎之

  ライフサイエンス出版(株), Feb. 2008, 治療学, 42(2) (2), 163 - 166, Japanese


• II-D-8 肥満患者に対する集学的治療における心療内科の関わり(コンサルテーション・リエゾン2,一般口演,情動ストレス研究の進歩と心身医学,第49回日本心身医学会総会ならびに学術講演会)

  瀧本 禎之, 吉内 一浩, 赤林 朗, 稲田 修士

  一般社団法人 日本心身医学会, 2008, 心身医学, 48(6) (6), 533, Japanese


• Ecological Momentary Assessmentを応用した夜間パニック発作の生理学的評価

  坂本 典之, 瀧本 禎之, 吉内 一浩, 熊野 宏昭, 赤林 朗

  (NPO)日本心療内科学会, Dec. 2007, 日本心療内科学会総会・学術大会プログラム・抄録集, 12回, 76 - 76, Japanese


• 【摂食障害の内科的治療】重症度に応じたプライマリケアのガイドライン

  熊野 宏昭, 瀧本 禎之, 鈴木 眞理, 大和田 里奈, 河合 啓介, 山田 祐, 権藤 元治, 芝崎 保

  (株)ニュー・サイエンス社, Oct. 2007, Medical Science Digest, 33(11) (11), 1124 - 1127, Japanese


• 【摂食障害 その診かたと治療】摂食障害 病因と臨床像 摂食障害にみられる身体合併症と精神合併症

  瀧本 禎之

  (株)新興医学出版社, Jun. 2007, Modern Physician, 27(6) (6), 773 - 777, Japanese


• 摂食障害患者における血漿グレリンと心理指標の関連について

  森屋 淳子, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (一社)日本心身医学会, Jun. 2007, 心身医学, 47(6) (6), 475 - 475, Japanese


• 神経性食欲不振症におけるアクチグラフを用いた過活動の評価(第1報)

  冨久尾 航, 瀧本 禎之, 吉内 一浩, 赤林 朗, 山本 義春

  (一社)日本心身医学会, Jun. 2007, 心身医学, 47(6) (6), 492 - 492, Japanese


• 神経性食欲不振症における心拍変動の非線形解析

  石澤 哲郎, 吉内 一浩, 瀧本 禎之, 赤林 朗

  (一社)日本心身医学会, Jun. 2007, 心身医学, 47(6) (6), 511 - 511, Japanese


• 東大病院内科研修医セミナー 著明な肝酵素上昇・汎血球減少を認めた後、行動療法により体重増加を認めた神経性食欲不振症の1例

  宮崎 信行, 稲田 修士, 鈴木 亜紀, 八塚 麻紀, 瀧本 禎之, 吉内 一浩, 赤林 朗

  (株)医学書院, Mar. 2007, Medicina, 44(3) (3), 604 - 608, Japanese


• 神経性食思不振症患者における甲状腺機能異常

  鈴木 亜紀, 瀧本 禎之, 吉内 一浩, 熊野 宏昭, 赤林 朗

  (NPO)日本心療内科学会, Dec. 2006, 日本心療内科学会総会・学術大会プログラム・抄録集, 11回, 62 - 62, Japanese


• プライマリケアでみる循環器心身症の診断と治療 循環器心身医学の最前線 循環器心身症の新しい診断と治療法の開発 Ecological Momentary Assessment(EMA)の応用

  吉内 一浩, 瀧本 禎之, 坂本 典之, 菊地 裕絵, 石澤 哲郎, 熊野 宏昭, 久保木 富房, 赤林 朗

  (NPO)日本心療内科学会, Nov. 2006, 日本心療内科学会誌, 10(4) (4), 216 - 216, Japanese


• A Survey on the Current State of Postgraduate Medical Ethics Education in Japan

  TAKIMOTO Yoshiyuki, NAGAO Noriko, SHIRAHAMA Masashi, OBAYASHI Masayuki, AKABAYASHI Akira, MORISHITA Naoki, SHOJI Shin'ichi

  To examine the present state of postgraduate ethics education for residents in Japan, we sent an anonymous self-administered questionnaire to the directors of all 640 hospitals in Japan with a registered postgraduate clinical residency program. A total of 258 hospitals returned the questionnaire (response rate: 40.3%). Of these hospitals, 69 (26.7%) had a program for ethics education and 189 (73.3%) did not. The presence of a program was strongly correlated with the number of hospital beds and a history of problems with ethics education. Respondents showed a high degree of awareness about such significant topics in ethics education as “informed consent, ” “patient privacy, ” “patient rights, ” and “physician duties.”

  Japan Society for Medical Education, Aug. 2006, Igaku Kyoiku / Medical Education (Japan), 37(4) (4), 215 - 220, Japanese


• Ecological Momentary Assessment法を用いたパニック障害における動悸症状の評価

  瀧本 禎之, 坂本 典之, 吉内 一浩, 熊野 宏昭, 赤林 朗

  (一社)日本心身医学会, Jun. 2006, 心身医学, 46(6) (6), 522 - 522, Japanese


• 摂食障害患者におけるメラノコルチン系の摂食関連ペプチドの変化

  森屋 淳子, 瀧本 禎之, 吉内 一浩, 熊野 宏昭, 赤林 朗

  (一社)日本心身医学会, Jun. 2006, 心身医学, 46(6) (6), 537 - 537, Japanese


• Physical and laboratory findings in anorexia nervosa patients

  TAKIMOTO Yoshiyuki

  (有)医学の世界社, Apr. 2006, ホルモンと臨床, 54(4) (4), 283 - 289, Japanese


• Papers at the 32th Annual Meeting

  吉内 一浩, 瀧本 禎之, 菊地 裕絵, 石澤 哲郎, 熊野 宏昭, 久保木 富房, 山本 義春

  Japanese Society of Biofeedback Research, Apr. 2006, Japanese journal of biofeedback research, 32, 45 - 45, Japanese


• A survey on the current state of hospital ethics consultation in Japan

  NAGAO Noriko, TAKIMOTO Yoshiyuki, AKABAYASHI Akira

  To examine the present state of clinical ethics consultation (EC) in Japan, an anonymous self-administered questionnaire was mailed to all resident-teaching hospitals (N=640). Questionnaires were returned from 267 hospitals (response rate, 41.7%). A total of 24.7% of hospitals answered "yes" to having a system of EC; 75.3% answered "no." At the majority of hospitals which answered "yes," an ethics committee would deal with ethical problems. Among hospitals that answered "no," 36.8% of institutions would solve ethical problems by "the director's judgment" and 18.4% would solve them by "entrusting the problem to the attending physician." Approximately 90% of hospitals indicated "a need" for EC. Overall, findings suggested that at most hospitals there exists a dire need for a support system to cope with ethical problems.

  Japan Association for Bioethics, Sep. 2005, Bioethics, 15(1) (1), 101 - 106, Japanese


• 「神経性食欲不振症外来患者にみられる医学的所見について」Miller KK,Grinspoon SK,Ciampa J,et al : Medical findings in outpatients with anorexia nervosa. Arch Intern Med 165:561-566,2005

  瀧本 禎之

  背景:大学生女性の約0.5〜1%が神経性食欲不振症に罹患しているといわれており, またその多くは地域にて通常の生活を営んでいると考えられる. しかしながら, 神経性食欲不振症に罹患している地域住民女性の臨床的データに関してはほとんど調査されていない. 方法:DSM-IVによって診断された214名(17〜45歳)の神経性食欲不振症患者に対して横断的な地域ベースの調査として, インタビュー, 身体学的診察, 採血, DXA法による骨密度測定が行われた. 結果:約半数の患者に入院歴がみられた. Purging行為を認める患者では罹病期間が有意に長かった. 75%が平均5.9時間/週の運動を行っていた. 74%がエストロゲン製剤を使用したことがあり, 30%が使用時に月経が再開していた. 73%に抗うつ薬の内服歴を認め, 47%は内服中であった. 平均心拍数は61.6拍/分であり, そのうち43%に除脈を認めた. 平均収縮期血圧は100.1mmHgであり, そのうち, 15%が90mmHg以下であった. 平均体温は36.6度であり, 22%が36度以下であった. 各所見は, 体重減少, 骨密度, 体脂肪率, 罹病期間, 運動時間と相関していた. 39%に貧血(94%が小球性)が, 34%に白血球数の減少が, 5%に血小板数の減少がみられた. 7%に低Na血症が認められた. 20%に低K血症が認められ, そのうちの48%に定期的なpurging行為が認められた. 2%で不整脈の既往を認め, 多くは低K血症が原因と考えられた. 6%に低Ca血症がみられた. 12%の患者でトランスアミラーゼが上昇していた. 各検査所見は体重減少, 骨密度, 体脂肪率, 罹病期間, 運動時間と相関していた. 最終月経からの期間は平均27.1ヵ月であった. 月経開始年齢の平均は13.6歳であり, 69%に開始年齢に遅れがみられた. 52%に骨塩量の低下がみられ, 34%に骨粗鬆症が認められた. 骨密度はBMIと%理想体重に強い相関を示していた. 30%の患者に骨折の既往が認められた. そのうちの42%が非外傷性であった. コメント:神経性食欲不振症患者では, 低栄養状態に伴うさまざまな合併症の存在が知られており, 同年齢女性の12倍の死亡率であるとも報告されている. 一方, 外来診察でみられる医学的所見に関して報告した文献は多くない. 本文献では多くの医学的所見が神経性食欲不振症を有する地域住民女性に認められたことが報告されている. その結果から, 神経食欲不振症の患者は定期的に身体的な診察と検査による評価を行い, 注意深くフォローされるべきであると著者らは述べている. 本文献は, 神経性食欲不振症に罹患した地域女性にみられる一般的医学的所見についての報告であり, 神経性食欲不振症患者の外来診療において参考になるものである.

  一般社団法人 日本心身医学会, 2005, 心身医学, 45(6) (6), 421, Japanese


• 【肥満症 生理活性物質と肥満の臨床】基礎編 摂食調節因子 Pancreatic polypeptide(PP)ファミリー

  瀧本 禎之, 乾 明夫

  (株)日本臨床社, Jul. 2003, 日本臨床, 61(増刊6 肥満症) (増刊6 肥満症), 64 - 69, Japanese


• 摂食障害患者のQT間隔とQT dispersion

  瀧本 禎之, 吉内 一浩, 宮坂 菜穂子, 山中 学, 佐々木 直, 熊野 昭宏, 永川 祐三, 久保木 富房, 末松 弘行

  (一社)日本心身医学会, Jul. 2002, 心身医学, 42(7) (7), 479 - 479, Japanese


• 消化器病研究のモデル動物 膵ポリペプチド過剰発現マウスによる消化管機能の検討

  瀧本 禎之, 乾 明夫

  (株)メディカルレビュー社, Oct. 2001, Frontiers in Gastroenterology, 6(4) (4), 385 - 392, Japanese


• 新規消化管ホルモンGhrelinに関する研究

  加賀 敏宏, 乾 明夫, 浅川 明弘, 杠葉 英樹, 永田 利謙, 瀧本 禎之, 後藤 恭子, 水田 保子, 黒木 理恵, 春日 雅人

  (一社)日本肥満学会, Sep. 2001, 肥満研究, 7(Suppl.) (Suppl.), 109 - 109, Japanese


• Ghrelinの不安に与える影響

  浅川 明弘, 乾 明夫, 加賀 敏宏, 水田 保子, 瀧本 禎之, 後藤 恭子, 杠葉 英樹, 永田 利謙, 春日 雅人

  (一社)日本肥満学会, Sep. 2001, 肥満研究, 7(Suppl.) (Suppl.), 164 - 164, Japanese


• 摂食障害患者のQT間隔,QT dispersion

  瀧本 禎之, 吉内 一宏, 山中 学, 佐々木 直, 熊野 宏明, 久保木 富房

  (有)科学評論社, May 2001, 心療内科, 5(3) (3), 199 - 202, Japanese


• IIF-2 摂食障害患者の自律神経機能とQT間隔及びQT dispersion : その1(摂食障害I)

  瀧本 禎之, 吉内 一浩, 長谷目 悦子, 大石 恵, 山中 学, 佐々木 直, 熊野 宏昭, 久保木 富房

  一般社団法人 日本心身医学会, 2001, 心身医学, 41(supplementII) (supplementII), 149, Japanese


• IIF-3 摂食障害患者の自律神経機能とQT間隔及びQT dispersion : その2(摂食障害I)

  吉内 一浩, 瀧本 禎之, 長谷目 悦子, 山中 学, 大石 恵, 熊野 宏昭, 久保木 富房, 佐々木 直

  一般社団法人 日本心身医学会, 2001, 心身医学, 41(supplementII) (supplementII), 150, Japanese


• 無茶食い患者に対する治療効果の予測因子について Peterson CB, Crow SJ, Nugent S, et al:Predictor of treatment outcome for binge eating disorder.Int J Eat Disord 28:131-138, 2000

  瀧本 禎之

  一般社団法人 日本心身医学会, 2001, 心身医学, 41(3) (3), 206, Japanese


• 摂食障害患者のQT間隔とQT Dispersion(第2報)

  瀧本 禎之, 吉内 一浩, 宮坂 菜穂子, 山中 学, 佐々木 直, 野村 忍, 久保木 富房

  循環器心身医学研究会, Jul. 2000, 循環器心身医学研究会会合記録, (56回) (56回), 2 - 4, Japanese


• 摂食障害患者におけるQT間隔とQT dispersion

  瀧本 禎之, 吉内 一浩, 宮坂 菜穂子, 山中 学, 佐々木 直, 野村 忍, 久保木 富房

  循環器心身医学研究会, Feb. 2000, 循環器心身医学研究会会合記録, (55回) (55回), 14 - 16, Japanese


• ID-1 演題「摂食障害患者のQT間隔とQT dispersion」(摂食障害(III))

  佐々木 直, 永川 祐三, 宮坂 菜穂子, 山中 学, 野村 忍, 瀧本 禎之, 久保木 富房, 吉内 一浩, 末松 弘行

  一般社団法人 日本心身医学会, 2000, 心身医学, 40(supplement) (supplement), 109, Japanese


• 「摂食障害患者を母親にもつ子どもたち」Waugh E, Bulik CM : Offspring of Women with Eating Disorders. Int J Eat Disord 20 : 123-133,1999

  瀧本 禎之

  一般社団法人 日本心身医学会, 1999, 心身医学, 39(6) (6), 487, Japanese

• 臨床倫理

  浅井, 篤, 高橋, 隆雄, 浅井, 篤, 会澤, 久仁子, 長尾, 式子, 三浦, 靖彦, 高橋, 隆雄, 大西, 基喜, 山崎, 康仕, 瀧本, 禎之, 西垣, 悦代, 武, ユカリ, 西田, 晃一, 尾藤, 誠司, 藤井, 可

  丸善出版, Apr. 2026, Japanese, ISBN: 9784621311165


• 入門・医療倫理

  赤林, 朗, 稲葉, 一人, 児玉, 聡, 瀧本, 禎之, 堂囿, 俊彦, 中澤, 栄輔, 奈良, 雅俊, 額賀, 淑郎, 前田, 正一, 水野, 俊誠, 山本, 圭一郎

  勁草書房, Feb. 2017, Japanese, ISBN: 9784326102600


• 生命倫理学とは何か : 入門から最先端へ

  Campbell, Alastair V., 山本, 圭一郎, 中澤, 栄輔, 瀧本, 禎之, 赤林, 朗

  勁草書房, Sep. 2016, Japanese, ISBN: 9784326102556


• 社会を変える健康のサイエンス : 健康総合科学への21の扉

  東京大学医学部健康総合科学科

  東京大学出版会, Jul. 2016, Japanese, ISBN: 9784130634069


• ケースブック患者相談

  瀧本, 禎之, 阿部, 篤子, 赤林, 朗

  医学書院, Jun. 2010, Japanese, ISBN: 9784260010405


• 新版TEGII活用事例集

  東京大学医学部心療内科TEG研究会

  金子書房, Jul. 2009, Japanese, ISBN: 9784760826278

• 意識障害の経験的生命倫理：理論、fNIRS、聞き取りによる「意識の価値」の再検討

  戸田 聡一郎, 瀧本 禎之, 高原 円, 長尾 式子

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 東北大学, 01 Apr. 2025 - 31 Mar. 2029


• 日本の病院における臨床倫理支援の質向上と均てん化を目指した実証的研究

  竹下 啓, 瀧本 禎之, 大貫 優子, 金田 浩由紀, 三浦 靖彦, 長尾 式子, 堂囿 俊彦

  日本学術振興会, 科学研究費助成事業, 基盤研究(B), 東海大学, 01 Apr. 2024 - 31 Mar. 2028

  プロジェクトA（臨床倫理委員会の標準化）：前年度実施した病院・臨床倫理委員会の実態調査について論文を作成した。また、日本臨床倫理学会第12回年次大会において、概要を報告した。また、新型コロナウイルス感染症パンデミック時における医療資源の配分に関する倫理的判断をめぐる日本での議論をまとめ、論文を投稿した。
  プロジェクトB（臨床倫理委員会支援体制の確立）：３つの大学病院において、2024年8月19日、10月3日、12月19日に臨床倫理支援体制を評価するための相互訪問事業を試行した。訪問前に、訪問を受ける病院が昨年度作成した自己評価表を記載し、それに基づき訪問する病院が質問を送付し、訪問を受ける病院が回答した。訪問当日は、臨床倫理支援体制のヒアリング、臨床倫理支援を担う会議体への陪席、質疑応答を行った。今後、訪問者と被訪問者を対象に質問紙調査を実施する予定である。その他、月1回の臨床倫理フォーラムを開催し、臨床倫理支援担当者間の意見交換会を継続した。病院・臨床倫理委員会連携会議を開催し、全国の病院における臨床倫理支援体制について意見交換を行った。また、意思決定支援、応招義務、精神疾患をもつ人の臨床倫理について、シンポジウムを開催した。
  プロジェクトC（臨床倫理コンサルテーション・レファレンス・ブック作成）：臨床倫理コンサルテーションの事例分析を継続した。また、神経難病の意思決定支援について文献的に検討し、論文を発表した。


• 臨床倫理的問題の判断メカニズムの解明および倫理理論構築と新アプローチ法の確立

  瀧本 禎之, 鈴木 真, 長尾 式子, 安村 明

  日本学術振興会, 科学研究費助成事業, 基盤研究(B), 東京大学, 01 Apr. 2024 - 31 Mar. 2026

  数回の試行を実施した結果、新たに臨床倫理ジレンマタスクのバッテリを組み直す必要性が生じたため、数回の検討を経てジレンマタスクの作成を行った。新たにバッテリを用いるための、fNIRS測定の専門家である分担研究者とともに解析方法も再検討した。
  
  
  その結果、fNIRの測定時間が3時間に及ぶことになったため、医療分野に従事する分担研究者が主に被験者のリクルートの従事し、新たに被験者をリクルートし直した。その結果、新な被験者として看護師22名、医師16名、臨床倫理の専門家8名をリクルート完了した。測定を順調に行うために、fNIRS測定の経験のある分担研究者のもとで経験のある専門家に指導をあおぎ、今後の測定の準備を行った。


• Problem Solving for Promoting Clinical Ethics Consultation

  Takimoto Yoshiyuki

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), The University of Tokyo, 01 Apr. 2017 - 31 Mar. 2022

  Remote supervision in clinical ethics consultation training was effective in both email and online formats. Among them, the 30-minute online format of supervision was found to be effective, including behavior change after six months. Significant differences were found in the attitudes of physicians and the general public toward various clinical ethical dilemmas. In particular, in life-threatening dilemmas, the general public gave more weight to the good conduct of physicians than to the physicians themselves. This led us to speculate on the prevalence of excessive self-determination supremacy among physicians.


• Ethics of neurofeedback

  Nakazawa Eisuke

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), The University of Tokyo, 01 Apr. 2017 - 31 Mar. 2020

  The purpose of this study was to focus on neurofeedback, which has been attracting attention in recent years, to examine its ethical issues and to evaluate its social acceptability. While neurofeedback technology has advanced rapidly in recent years, analysis from an ethical perspective is still in its infancy. The ethical points are social acceptance, informed consent, and risk / benefit evaluation. In particular, it was found that risk evaluation and social acceptability regarding the irreversibility of the neurofeedback technology are the ethical points of this technology.


• Usefulness of apparent diffusion coefficient (ADC) value by 3-tesla MRI system to evaluate the graft fibrosis after kidney transplantation

  Ishimura Takeshi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2015 - 31 Mar. 2018

  To understand the factors that influence living kidney donor’s decision-making procedure, we systematically collected relevant studies from multiple databases and conducted qualitative and inductive analyses to identify the factors that influence donor’s autonomous decision-making. Subsequently, we conducted semistructured interviews on 15 healthcare professionals who engaged in living kidney transplantation with the interview guide that was made based on the outcome of the previous systematic review. Several themes were presented, for example, a perception gap between them relating to circumstances during informed consent or clinical practice for donors. And there was un uncertainty how one candidate has been selected from more than one candidates. We are conducting an interview survey on donors to add multilateral perspectives for decision-making process of donors, which may have significant potential to assume an important role in establishing future decision support methods.


• Empirical research aimed at improving the research ethics support services

  UETAKE YUZABURO

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), The University of Tokyo, 01 Apr. 2014 - 31 Mar. 2018

  Through this empirical research, we were better able to understand the actual circumstances regarding our research ethics support services, and it became clear that the research ethics review systems in the University of Tokyo should be improved. Furthermore, by comparing research ethics review systems of other facilities with its operational aspects, we were able to identify areas to improve in the operations of the University of Tokyo, and we now recognize the necessity of developing an ecosystem surrounding ethical review nationwide. By better understanding the actual circumstances regarding the services, we are better able to predict the services that fit the actual needs, which helps to further improve the services. This research, we believe, is meaningful in that it was able to directly impact research ethics support services to further the positive development of medical research.


• Ethical coping with refusal treatment of eating disorders

  Takimoto Yoshiyuki

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), The University of Tokyo, 01 Apr. 2013 - 31 Mar. 2017

  Regarding response to treatment rejection of patients with eating disorders, two points- "best interest" and "mental capacity" were extracted by literature research. As a result of investigating the consciousness of experts of eating disorders treatment in Japan, compulsive treatment was choosed at the time of life crisis, because of considering "best interest" in eating disorders patients is life sustaining, while "mental capacity" of eating disorders patients was acknowledged. It became clear that the thought on forced treatment is thought by the health administration side as well. Even in comparison with overseas, the tendency to select compulsive treatment at the time of life crisis was recognized as well, while admitting certain mental capacity. However, in Japan, there was a characteristic that there was a strong tendency to make consent for families as to the basis of compulsive treatment.


• 血管内皮機能を指標とした摂食障害患者の病態解明とその臨床応用に関する研究

  宮脇 佳世, 瀧本 禎之, 坂本 淳子(森屋淳子), 五島 史行

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 東京女子医科大学, 01 Apr. 2013 - 31 Mar. 2015

  神経性食欲不振症は年々増加傾向にある。心理的な要因で発症するが、重篤な内科的合併症も問題となり、身体的治療の必要性も高い。神経性食欲不振症における体液貯留は、重篤な身体合併症を引き起こすだけでなく、体重増加による心理的な負荷をもたらし、治療を困難にする一因となる。神経性食欲不振症の病態は栄養状態や罹病期間により異なり、大変複雑であり、いまだ明らかになっていないメカニズムが多い。そこで本研究は、身体合併症である体液貯留を予防し、治療へと応用するために、血管内皮細胞に着目して病態メカニズムを解明する目的で開始した。まず、神経性食欲不振症の身体合併症の主たる病因となる栄養飢餓が、血管内皮細胞に与える影響とそれによる病態を調べるために、培養細胞を用いて栄養飢餓モデルを作成した。栄養飢餓群として、無血清培地、FCS5%を含む培地を使用した。それぞれの溶液で、30分から240分間、血管内皮細胞を処理すると、時間依存性にオートファジーが誘導された。オートファジーは免疫蛍光抗体染色法を用い、LC3の発現にて確認した。先行研究において、栄養飢餓ではほとんどのすべての臓器でオートファジーが誘導されていることが知られている。そのため、オートファジーが誘導されている培養細胞を栄養飢餓群とし、通常培地で処理された健常群と、細胞間接着の機能と構造について比較検討を行っていく。さらに細胞間接着とオートファジーの関連性を確認していく。


• Establishment of education and training method of ethics consultation based on the current state of hospital ethics committees in Japan

  DOWA Yuri, TAKIMOTO Yoshiyuki

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kyoto University, 01 Apr. 2012 - 31 Mar. 2015

  We carried out a questionnaire, interviews and a content analysis to establish education and training method of hospital ethics committee (HEC) in Japan. The questionnaire survey was carried out for the 2433 hospitals certified by Japan Council for Quality Health Care. We also interviewed eight people of six hospitals who had much ethics consultation (EC) experience. Furthermore, a content analysis about 32 oncological EC records was carried out at University of Tokyo Hospital patient relations and clinical ethics consultation center. As the result, the barriers to promote HEC were popularity among hospital staff, awareness of ethical issue, and equally relationship. Further most essential things to do EC were decision-making, notification and relatives. To educate and train to do EC, case studies focused on autonomy and role playing method were most effective. We also found the secretariat was important to conduct HEC.


• Fundamental research in Japanese clinical ethics consultation

  AKABAYASHI Akira, TAKIMOTO Yoshiyuki, KODAMA Satoshi, MAEDA Shoichi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), The University of Tokyo, 2009 - 2011

  A system that integrates clinical ethics consultation services(CECs) with the Japanese clinical setting was developed based on an observational study of CECs in U. S. medical organizations and past activities of the Patient Relations and Ethics Center(PREC) of the University of Tokyo Hospital. The system was named "The University of Tokyo Hospital Model." Educational tools of CECs in Japan were developed based on an analysis of past consultation cases collected by PREC, and published as a regular feature or in casebook form.


• Biomarker of gastrointestinal function in anorexia nervosa patients

  TAKIMOTO Yoshiyuki

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), The University of Tokyo, 2008 - 2010

  Plasma diaminoxidase (DAO) activities as the biomarker of gastrointestinal function were investigated in anorexia nervosa (AN) patients. Subjects were 33 female AN patients (18 AN-R and 15 AN-BP patients) and 20 healthy women. Plasma DAO activities were measured using Takagi's sensitive colorimetric assay method. The baseline plasma DAO activities in AN-R, AN-BP and healthy women were 11.5±4.7, 11.3±2.7 and 12.8±2.4 u/ml, respectively. There were no significant difference in plasma DAO activities between AN patients and controls. On the other hand, the plasma DAO activity at the time of discharge were significantly more decreased than at the time of admission (admission 11.7±3.7 u/ml, discharge 9.9±3.2 u/ml). There may be possibility of plasma DAO activity as one of biomarkers reflecting refeeding in AN patients.


• 摂食障害患者における加速度計を用いた排出行動の客観的評価方法の開発

  瀧本 禎之

  日本学術振興会, 科学研究費助成事業, 若手研究(B), 東京大学, 2006 - 2007

  本年度は、採取したデータの処理および解析を行った。対象は,東京大学医学部附属病院心療内科に通院中の神経性食欲不振症患者9名(制限型5名、むちゃ食い/排出型4名)および健常女性7名であった。方法に関しては,腕時計型のアクチグラフ(加速度計)を1週間携帯することにより、日常生活下での身体活動のデータ採取を行った。食事の時間帯および過食や排出行動を記録するために、生活記録表(行動日誌)の携帯および記録を同時に行った。身体活動の基礎的解析として、1日平均身体活動数を患者群と健常群との間で比較した。また,むちゃ食い/排出型患者のデータを用いて、過食および排出行動前後の身体活動データの観察を行い、仮説生成を試みた。結果は,平均年齢および平均BMI (Body Mass Index)は、患者群で27.0歳(SD 6.9)、14.8kg/m^2 (SD 1.8)、健常群で23.3歳(SD 2.1)、20.1kg/m^2 (SD 1.2)であった。一日平均身体活動量は患者群で163094counts/day (SD 34560)、健常群で180527 counts/day (SD 24223)であり、グループ間で統計学的な有意差を認めなかった。むちゃ食い/排出型患者のデータの観察では、過食や排出行動前では、過食や排出行動のない食事前と比べて、身体活動量が小さくなるデータの傾向を認めた。従って,今後さらに洗練された解析手法を開発することによって,過食や排出行動の検知や予測を行い,これらの病的食行動に対する予防的介入の可能性が示唆された。