Research activity information

• Jun. 2024 JSCRS（公益社団法人日本白内障屈折矯正手術学会）, 第39回JSCRS学術総会 トラベルグラント


• Apr. 2024 日本緑内障学会, 第37回須田記念緑内障治療研究奨励基金(須田賞)


• Mar. 2023 日本眼科学会, JOS Young Investigator Award


• Dec. 2021 日本神経眼科学会, 日本神経眼科学会学術賞


• Mar. 2021 日本緑内障学会, 第1回一般財団法人北澤克明記念緑内障学研究助成金（北澤賞）


• Sep. 2020 日本臨床視覚電気生理学会, 日本臨床視覚電気生理学会 優秀発表賞

• Evaluation of Brain and Spinal Cord Lesions and Cerebrospinal Fluid Analysis in Detecting Demyelinating Diseases in Patients with Optic Neuritis

  Sotaro Mori, Norio Chihara, Yuto Iwaki, Mina Okuda-Arai, Fumio Takano, Kaori Ueda, Mari Sakamoto, Yuko Yamada-Nakanishi, Riki Matsumoto, Makoto Nakamura

  Mar. 2025, Neuro-Ophthalmology

  Scientific journal


• Three-year outcomes of surgical bleb revision with mitomycin C for early scarring bleb after trabeculectomy.

  Risa Caraher-Masuda, Mari Sakamoto, Mina Okuda, Fumio Takano, Sotaro Mori, Kaori Ueda, Akiyasu Kanamori, Yuko Yamada-Nakanishi, Makoto Nakamura

  PURPOSE: To report the 3-year outcomes of surgical bleb revision (SBR) with mitomycin C (MMC) for early scarring bleb after trabeculectomy (TLE). STUDY DESIGN: Retrospective observational study. METHODS: We included glaucoma patients aged ≧ 18 who underwent SBR with MMC within 6 months of their first TLE at Kobe University Hospital and were followed for at least 6 months. The primary outcome measure was the three-year success rate of SBR. We defined surgical success as: intraocular pressure (IOP) reduction ≧ 20% from baseline and 5 ≦ IOP ≦ 18 mmHg. Failure was defined when the IOP deviated from the criteria, when the eye required additional glaucoma surgery, and when the eye lost light perception. Complete success (CS) was success without glaucoma medications and qualified success (QS) was success with glaucoma medications. The secondary outcome measures included IOP, the number of glaucoma medications, mean deviation (MD), best corrected visual acuity (BCVA), corneal endothelial cell density (ECD), and surgical complications. RESULTS: Sixty-eight eyes of 68 patients were analyzed. The median interval between initial TLE and SBR was 2 months. Overall success rate at three-year after SBR were 45.1% and 9.6% for QS and CS, respectively. A greater number of medications used before TLE was a contributing factor to failure (P = 0.02). 22 eyes (32.4%) underwent additional glaucoma surgery, and 41 eyes (60.3%) were spared from additional glaucoma surgery within 3 years after SBR. The median IOP decreased form 24.0 mmHg to 11.0 mmHg 3 years after SBR, and the number of medications decreased from 4 to 2 (P < 0.01). MD remained unchanged, but BCVA and ECD decreased at 3years postoperatively. There were no serious complications of SBR. CONCLUSION: SBR may be an effective treatment option for early scarring blebs after TLE but is unsuccessful in eyes that have used many glaucoma medications prior to TLE.

  Nov. 2024, Japanese journal of ophthalmology, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• One-year results of trabeculectomy with emphasis on the effect of patients' age.

  Yuto Iwaki, Sotaro Mori, Mina Okuda-Arai, Fumio Takano, Kaori Ueda, Mari Sakamoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  PURPOSE: This study investigated the association between one-year surgical outcomes following trabeculectomy and age, accounting for confounding factors. STUDY DESIGN: Retrospective observational study. METHOD: Analyzing data from 305 patients undergoing initial trabeculectomy from 2019 onward, we employed three approaches to adjust variables: stratified analysis, regression analysis, and propensity score matching. Surgical success at 1-year post-surgery was defined by two criteria: achieving intraocular pressure of between 5 and 15 mmHg with a ≥ 20% reduction compared to pre-surgery levels and no additional glaucoma surgery (Criterion A); achieving intraocular pressure of between 5 and 12 mmHg with a ≥ 30% reduction compared to pre-surgery levels and no additional glaucoma surgery (Criterion B). RESULTS: Stratified analysis by age unveiled a significant increase in exfoliation glaucoma (XFG) and a trend towards shorter axial lengths with advancing age (both p < 0.0001). Older age groups were more likely to experience surgical failure in both Criterion A and B (p = 0.21, < 0.01). Univariate analysis showed age as a significant factor in surgical failure for Criterion A (p < 0.05) and a nearly significant factor for Criterion B (p = 0.12). However, this trend was not evident in multivariate analysis (p = 0.23/0.88), where XFG became a significant factor for surgical failure (both p < 0.001) in Criteria A and B. Propensity score matching revealed no significant differences in surgical success rates for Criteria A and B between younger and older patients (p = 1.00 and 0.88). CONCLUSION: Age is not a primary determinant of failure in trabeculectomy; however, the increasing incidence of XFG with aging suggests a potential for poorer outcomes.

  Corresponding, Oct. 2024, Japanese journal of ophthalmology, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Impact of glaucoma medications on subsequent Schlemm's canal surgery outcome: Cox proportional hazard model and propensity score‐matched analysis

  Mina Okuda‐Arai, Sotaro Mori, Fumio Takano, Kaori Ueda, Mari Sakamoto, Yuko Yamada‐Nakanishi, Makoto Nakamura

  Corresponding, Mar. 2024, Acta Ophthalmologica

  Scientific journal


• Potentially compromised systemic and local lactate metabolic balance in glaucoma, which could increase retinal glucose and glutamate concentrations.

  Mina Arai-Okuda, Yusuke Murai, Hidetaka Maeda, Akiyasu Kanamori, Takako Miki, Tomoko Naito, Kazunobu Sugihara, Michihiro Kono, Masaki Tanito, Hiromitsu Onoe, Kazuyuki Hirooka, Yoshiaki Kiuchi, Masakazu Shinohara, Sentaro Kusuhara, Sotaro Mori, Kaori Ueda, Mari Sakamoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  To investigate the association between lactate metabolism and glaucoma, we conducted a multi-institutional cross-sectional clinical study and a retinal metabolomic analysis of mice with elevated intraocular pressure (IOP) induced by intracameral microbead injection. We compared lactate concentrations in serum and aqueous humor in age-matched 64 patients each with primary open-angle glaucoma (POAG) and cataract. Neither serum nor aqueous humor lactate concentrations differed between the two groups. Multiple regression analysis revealed that only body mass index showed a significant positive correlation with serum and aqueous humor lactate concentration in POAG patients (rs = 0.376, P = 0.002, and rs = 0.333, P = 0.007, respectively), but not in cataract patients. L-Lactic acid was one of the most abundantly detected metabolites in mouse retinas with gas chromatography and mass spectrometry, but there were no significant differences among control, 2-week, and 4-week IOP elevation groups. After 4 weeks of elevated IOP, D-glucose and L-glutamic acid ranked as the top two for a change in raised concentration, roughly sevenfold and threefold, respectively (ANOVA, P = 0.004; Tukey-Kramer, P < 0.05). Glaucoma may disrupt the systemic and intraocular lactate metabolic homeostasis, with a compensatory rise in glucose and glutamate in the retina.

  Feb. 2024, Scientific reports, 14(1) (1), 3683 - 3683, English, International magazine

  Scientific journal


• Efficacy and safety of transdermal electrical stimulation in patients with nonarteritic anterior ischemic optic neuropathy.

  Gen Miura, Tadami Fujiwara, Yoshihito Ozawa, Yuki Shiko, Yohei Kawasaki, Tomohiro Nizawa, Tomoaki Tatsumi, Takuji Kurimoto, Sotaro Mori, Makoto Nakamura, Hideki Hanaoka, Takayuki Baba, Shuichi Yamamoto

  BACKGROUND: No effective treatment for NAION with strong evidence has been established till date. The aim of this investigator-led, prospective, non-randomized, open-label, uncontrolled multi-center exploratory clinical trial is to evaluate the efficacy and safety of transdermal electrical stimulation (TdES) using skin electrodes in patients with NAION. METHODS: Five patients with monocular NAION underwent TdES (10-ms biphasic pulses, 1.0 mA, 20 Hz, 30 min) of the affected eye six times at 2-week intervals. The primary endpoint was the logarithm of the mini-mum angle of resolution (logMAR) visual acuity at 12 weeks compared with 0 weeks. The secondary endpoints were changes in the best-corrected logMAR visual acuity, Early Treatment of Diabetic Retinopathy Study (ETDRS) visual acuity, and mean deviation (MD) of the Humphrey field analyzer (HFA) 10-2 and HFA Esterman test scores. Additionally, the safety of TdES was evaluated. RESULTS: LogMAR visual acuity improved by ≥ 0.1 in two eyes, and ETDRS visual acu-ity improved by ≥ 5 characters in one eye. The mean change in logMAR visual acuity from week 0 showed an increasing trend. The mean MD of HFA 10-2 showed no obvious change, while HFA Esterman score improved in four eyes. All patients completed the study according to the protocol, and no treatment-related adverse events were observed. CONCLUSIONS: TdES treatment may have improved visual acuity and visual field in some patients. Further sham-controlled study in larger cohort is needed on its effectiveness. TRIAL REGISTRATION: UMIN, UMIN000036220. Registered 15 March, 2019, https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000041261 .

  Oct. 2023, Bioelectronic medicine, 9(1) (1), 22 - 22, English, International magazine

  Scientific journal


• Effects of elevated intraocular pressure on retinal ganglion cell density and expression and interaction of retinal aquaporin 9 and monocarboxylate transporters.

  Murai Y, Mori S, Okuda M, Kusuhara S, Kurimoto T, Nakamura M

  Introduction Astrocyte-to-neuron lactate shuttle (ANLS) plays an important role in the energy metabolism of neurons, including retinal ganglion cells (RGCs). Aquaporin 9 (AQP9), which is an aquaglyceroporin that can transport lactate, may be involved in ANLS together with monocarboxylate transporters (MCTs) to maintain RGC function and survival. This study aimed to investigate the impact of elevated intraocular pressure (IOP) on AQP9-MCT interaction and RGC survival. Methods IOP was elevated in Aqp9 knock-out (KO) mice and wild-type (WT) littermates by anterior chamber microbead injection. RGC density was measured by TUBB3 immunostaining on retinal flat mounts. Immunolabeling, immunoblot, and immunoprecipitation were conducted to identify and quantitate expressions of AQP9, MCT1, MCT2, and MCT4 in whole retinas and ganglion cell layer (GCL). Results Aqp9 KO and WT mice had similar RGC density at baseline. Microbead injection increased cumulative IOP by approximately 32% up to 4 weeks, resulting in RGC density loss of 42% and 34% in WT and Aqp9 KO mice, respectively, with no statistical difference. In the retina of WT mice, elevated IOP decreased the amount of AQP9, MCT1, and MCT2 protein and changed the AQP9 immunoreactivity and reduced MCT1 and MCT2 immunoreactivities in GCL. Meanwhile, it decreased MCT1 and increased MCT2 that interact with AQP9, without affecting MCT4 expression. Aqp9 gene deletion increased baseline MCT2 expression in the GCL and counteracted IOP elevation regarding MCT1 and MCT2 expressions. Discussion/Conclusion The compensatory upregulation of MCT1 and MCT2 with Aqp9 gene deletion and ocular hypertension may reflect the need to maintain lactate transport in the retina for RGC survival.

  Aug. 2023, Ophthalmic Research

  Scientific journal


• Favorable effect of ripasudil use on surgical outcomes of microhook ab interno trabeculotomy.

  Okuda M, Mori S, Ueda K, Sakamoto M, Kusuhara S, Yamada-Nakanishi Y, Makoto Nakamura

  Purpose

  We have previously demonstrated that prolonged use of glaucoma medications was associated with a poor surgical outcome of ab interno trabeculotomy (µTLO). Given that almost all types of glaucoma eye drop either enhance the drainage through the uveoscleral pathway or reduce aqueous humor production, we hypothesized that prolonged use of these medications might cause disuse atrophy of the conventional pathway. In contrast, ripasudil increases the conventional outflow and eventually shows a favorable outcome of µTLO. This study aimed to evaluate the effect of ripasudil use on µTLO outcomes.

  Method

  The medical charts of 218 patients who underwent µTLO were analyzed retrospectively. We compared the 1-year outcome between ripasudil users versus nonusers by using propensity score matching. We set the covariates as age, sex, glaucoma types, preoperative intraocular pressure (IOP), the mean deviation values of visual field tests, the presence or absence of concomitant cataract surgery, trabecular meshwork incision range, the presence or absence of any glaucoma medication except ripasudil and duration of glaucoma medical therapy. Success was defined as a postoperative IOP between 5 and 21 mmHg, a ≥ 20% IOP reduction from baseline, and no additional glaucoma surgery at postoperative 1 year.

  Result

  Fifty-seven patients each were allocated to the ripasudil users or nonusers. The 1-year success rates were 74% in ripasudil users and 51% in nonusers (p = 0.01). Kaplan‒Meier survival curves also showed that the ripasudil users had a higher survival distribution (p = 0.01).

  Conclusion

  The patients who took ripasudil showed a favorable 1-year outcome of µTLO.

  Corresponding, Mar. 2023, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

  Scientific journal


• Exploratory clinical trial to evaluate the efficacy and safety of transdermal electrical stimulation in patients with central retinal artery occlusion.

  Gen Miura, Fujiwara T, Iwase T, Ozawa Y, Shiko Y, Kawasaki Y, Nizawa T, Tomoaki Tatsumi, Baba T, Kurimoto T, Sotaro Mori, Makoto Nakamura, Hanaoka H, Yamamoto S

  Purpose

  To evaluate the efficacy and safety of transdermal electrical stimulation (TdES) using skin electrodes in patients with central retinal artery occlusion (CRAO).

  Methods

  Five eyes of five patients with CRAO underwent TdES (10-ms biphasic pulses, 20 Hz, 30 min) six times at 2-week intervals. Only the affected eye was stimulated with 1.0-mA pulses in all patients. The primary endpoint was the best-corrected logMAR visual acuity. The secondary endpoints were changes in the best-corrected logMAR visual acuity, Early Treatment of Diabetic Retinopathy Study (ETDRS) visual acuity, mean deviation of the Humphrey field analyzer (HFA) 10-2, and HFA Esterman test score. We also evaluated its safety.

  Results

  The logMAR visual acuity at 12 weeks was improved by 0.1 or more in two patients and was maintained in two patients compared to the baseline. No obvious changes in the mean logMAR visual acuity, ETDRS visual acuity, mean deviation, and HFA Esterman score were observed at 12 weeks compared to the baseline. All five enrolled patients completed the study according to the protocol. No treatment-related adverse events were observed during this study.

  Conclusion

  In this study, logMAR visual acuity was slightly improved in two patients, confirming the safety of TdES. Since CRAO has no established treatment method, further research into the effects of TdES treatment in CRAO patients may be beneficial.

  Feb. 2023, PloS one

  Scientific journal


• Efficacy and safety of mycophenolate mofetil for steroid reduction in neuromyelitis optica spectrum disorder: a prospective cohort study

  Ritsu Akatani, Norio Chihara, Shusuke Koto, Sotaro Mori, Takuji Kurimoto, Makoto Nakamura, Hisatsugu Tachibana, Yoshihisa Otsuka, Takehiro Ueda, Takashi Omori, Kenji Sekiguchi, Riki Matsumoto

  Dec. 2022


• Risk of surgical failure and hemorrhagic complications associated with antithrombotic medication in glaucoma surgery

  Fumio Takano, Sotaro Mori, Mina Okuda, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  Corresponding, Springer Science and Business Media {LLC}, Jun. 2022, Graefe's Archive for Clinical and Experimental Ophthalmology, English

  Scientific journal


• Outcomes of Microhook ab Interno Trabeculotomy in Consecutive 36 Eyes with Uveitic Glaucoma

  Noriyuki Sotani, Sentaro Kusuhara, Wataru Matsumiya, Mina Okuda, Sotaro Mori, Rei Sotani, Kyung Woo Kim, Ryuto Nishisho, Makoto Nakamura

  Jun. 2022, Journal of Clinical Medicine, 11(13) (13)

  Scientific journal


• Association of the prolonged use of anti-glaucoma medications with the surgical failure of ab interno microhook trabeculotomy.

  Mina Okuda, Sotaro Mori, Fumio Takano, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  Corresponding, Jan. 2022, Acta ophthalmologica

  Scientific journal


• The beneficial impact of filtration surgery on antiviral therapy cessation in patients with cytomegalovirus-related secondary glaucoma

  Yusuke Murai, Sotaro Mori, Fumio Takano, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Sentaro Kusuhara, Yuko Yamada-Nakanishi, Makoto Nakamura

  Springer Science and Business Media {LLC}, Dec. 2021, BMC Ophthalmology, 21(1) (1), English

  Scientific journal


• Non-inferiority of Microhook to Trabectome: Trabectome vs. ab interno Microhook Trabeculotomy Comparative Study (TramTrac Study)

  Sotaro Mori, Masaki Tanito, Nobuyuki Shoji, Yu Yokoyama, Takanori Kameda, Takuhei Shoji, Shiro Mizoue, Yuta Saito, Kyoko Ishida, Toshihiko Ueda, Makoto Nakamura

  Lead, Elsevier {BV}, Nov. 2021, Ophthalmology Glaucoma, 5(4) (4), English

  Scientific journal


• Protocol to test the efficacy and safety of frequent applications of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomised prospective study

  Kaori Ueda, Takuji Kurimoto, Fumio Takano, Yusuke Murai, Sotaro Mori, Mari Sakamoto, Takayuki Nagai, Yuko Yamada-Nakanishi, Makoto Nakamura

  {BMJ}, Oct. 2021, BMJ Open, 11(10) (10), English

  Scientific journal


• 視神経挫滅後のアクアポリン9ノックアウトマウスにおける網膜神経節細胞の機能低下と乳酸輸送障害の関係

  盛 崇太朗, 栗本 拓治, 三木 明子, 前田 秀高, 楠原 仙太郎, 中村 誠

  眼科臨床紀要会, Jul. 2021, 眼科臨床紀要, 14(7) (7), 452 - 452, Japanese


• Autologous Scleral Pocket Technique for Ahmed Glaucoma Valve Implantation with Pars Plana Tube Insertion for Neovascular Glaucoma

  Hitomi Maki, Sotaro Mori, Hisanori Imai, Hiroko Yamada, Keiko Otsuka, AKIKO MIKI, Sentaro Kusuhara, Makoto Nakamura

  Corresponding, Apr. 2021, Journal of Clinical Medicine, 10(8) (8)

  Scientific journal


• Three-year outcome of sulcus fixation of Baerveldt glaucoma implant surgery.

  Sotaro Mori, Noriyuki Sotani, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  Lead, Mar. 2021, Acta ophthalmologica, 99(8) (8)

  Scientific journal


• Changes in Gene Expression Profiling and Phenotype in Aged Multidrug Resistance Protein 4-Deficient Mouse Retina

  Kyung Woo Kim, Sentaro Kusuhara, Atsuko Katsuyama-Yoshikawa, Sho Nobuyoshi, Megumi Kitamura, Sotaro Mori, Noriyuki Sotani, Kaori Ueda, Wataru Matsumiya, Akiko Miki, Takuji Kurimoto, Hisanori Imai, Makoto Nakamura

  Mar. 2021, Antioxidants, 10(3) (3)

  Scientific journal


• Comparison of efficacy and early surgery-related complications between one-quadrant and two-quadrant microhook ab interno trabeculotomy: a propensity score matched study.

  Sotaro Mori, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  Lead, Feb. 2021, Acta ophthalmologica, 99(8) (8)

  Scientific journal


• Granulomatosis with Polyangiitis Presenting with Bilateral Orbital Apex Syndrome.

  Yusuke Murai, Takuji Kurimoto, Sotaro Mori, Kaori Ueda, Mari Sakamoto, Kengo Akashi, Yuko Yamada-Nakanishi, Makoto Nakamura

  Jan. 2021, Case reports in ophthalmology, 12(1) (1)

  Scientific journal


• Dimethyl Fumarate Promotes the Survival of Retinal Ganglion Cells after Optic Nerve Injury, Possibly through the Nrf2/HO-1 Pathway

  Sotaro Mori, Takuji Kurimoto, HIDETAKA MAEDA, Makoto Nakamura

  Lead, Dec. 2020, International Journal of Molecular Sciences, 22(1) (1)

  Scientific journal


• Aqp9 Gene Deletion Enhances Retinal Ganglion Cell (RGC) Death and Dysfunction Induced by Optic Nerve Crush: Evidence that Aquaporin 9 Acts as an Astrocyte-to-Neuron Lactate Shuttle in Concert with Monocarboxylate Transporters To Support RGC Function and Survival

  Sotaro Mori, Takuji Kurimoto, Akiko Miki, Hidetaka Maeda, Sentaro Kusuhara, Makoto Nakamura

  Lead, Springer Science and Business Media {LLC}, Nov. 2020, Molecular Neurobiology, 57(11) (11), 4530 - 4548, English

  Scientific journal


• A case of neurosarcoidosis presenting with multiple cranial neuropathies.

  Sotaro Mori, Takuji Kurimoto, Kaori Ueda, Mari Sakamoto, Norio Chihara, Wataru Satake , Yuko Yamada-Nakanishi, Makoto Nakamura

  Lead, Jun. 2020, American journal of ophthalmology case reports, 19

  Scientific journal


• A Single-Arm, Prospective, Exploratory Study to Preliminarily Test Effectiveness and Safety of Skin Electrical Stimulation for Leber Hereditary Optic Neuropathy

  Takuji Kurimoto, Kaori Ueda, Sotaro Mori, Seiko Kamada, Mari Sakamoto, Yuko Yamada-Nakanishi, Wataru Matsumiya, Makoto Nakamura

  {MDPI} {AG}, May 2020, Journal of Clinical Medicine, 9(5) (5), 1359 - 1359, English

  Scientific journal


• A comparison of the 1-year surgical outcomes of ab externo trabeculotomy and microhook ab interno trabeculotomy using propensity score analysis.

  Sotaro Mori, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  Lead, Mar. 2020, BMJ open ophthalmology, 5(1) (1)

  Scientific journal


• En face slab optical coherence tomography imaging successfully monitors progressive degenerative changes in the innermost layer of the diabetic retina.

  Atsuko Katsuyama, Sentaro Kusuhara, Shun-Ichiro Asahara, Shun-Ichiro Nakai, Sotaro Mori, Wataru Matsumiya, Akiko Miki, Takuji Kurimoto, Hisanori Imai, Yoshiaki Kido, Wataru Ogawa, Makoto Nakamura

  Mar. 2020, BMJ open diabetes research & care, 8(1) (1)

  Scientific journal


• Efficacy for the Annual Relapse Rate after the Immunosuppressive Therapy in Patients Associated with Anti-AQP4 or Anti-MOG Antibody-Positive Optic Neuritis

  Sotaro Mori, Takuji Kurimoto, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Norio Chihara, Yuko Yamada-Nakanishi, Makoto Nakamura

  Lead, 2020, Journal of Ophthalmology, 2020

  Scientific journal


• A Case of Multi-System Langerhans Cell Histiocytosis with Local Invasion of the Orbital Apex.

  Hiroko Yamada, Takuji Kurimoto, Sotaro Mori, Mari Sakamoto, Kaori Ueda, Yuko Yamada-Nakanishi, Yoichi Uozumi, Hiroyasu Shose, Masaaki Taniguchi, Masanori Toyoda, Hironobu Minami, Makoto Nakamura

  Sep. 2019, Case reports in ophthalmology, 10(3) (3)

  Scientific journal


• 再発性視神経炎に対する免疫抑制剤の治療効果

  盛 崇太朗, 栗本 拓治, 村井 佑輔, 上田 香織, 坂本 麻里, 千原 典夫, 中西 裕子[山田], 中村 誠

  日本神経眼科学会, Aug. 2019, 神経眼科, 36(増補1) (増補1), 55 - 55, Japanese

  [Refereed]


• En Face Slab Images Visualize Nerve Fibers With Residual Visual Sensitivity in Significantly Thinned Macular Areas of Advanced Glaucomatous Eyes.

  Mari Sakamoto, Sotaro Mori, Kaori Ueda, Takuji Kurimoto, Sentaro Kusuhara, Yuko Yamada-Nakanishi, Makoto Nakamura

  Jul. 2019, Investigative ophthalmology & visual science, 60(8) (8)

  Scientific journal


• A study protocol for evaluating the efficacy and safety of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomized prospective exploratory study.

  Takuji Kurimoto, Kaori Ueda, Sotaro Mori, Mari Sakamoto, Yuko Yamada-Nakanishi, Wataru Matsumiya, Makoto Nakamura

  May 2019, Clinical ophthalmology (Auckland, N.Z.), 13

  Scientific journal


• Discordance of Disc-Fovea Raphe Angles Determined by Optical Coherence Tomography and MP-3 Microperimetry in Eyes With a Glaucomatous Hemifield Defect.

  Sotaro Mori, Takuji Kurimoto, Akiyasu Kanamori, Mari Sakamoto, Kaori Ueda, Yuko Yamada-Nakanishi, Makoto Nakamura

  Lead, Apr. 2019, Investigative ophthalmology & visual science, 60(5) (5)

  Scientific journal


• The Difficulty of Diagnosing Invasive Aspergillosis Initially Manifesting as Optic Neuropathy.

  Sotaro Mori, Takuji Kurimoto, Kana Kawara, Kaori Ueda, Mari Sakamoto, Yukako Keshi, Yuko Yamada-Nakanishi, Hisatsugu Tachibana, Makoto Nakamura

  Lead, Jan. 2019, Case reports in ophthalmology, 10(1) (1)

  Scientific journal


• 片眼の動眼神経麻痺と僚眼の外転神経麻痺を呈したサルコイドーシスの1例

  盛 崇太朗, 栗本 拓治, 荒木 健, 坂本 麻里, 上田 香織, 大塚 喜久, 芥子 結香子, 佐竹 渉, 中西 裕子, 中村 誠

  日本神経眼科学会, Nov. 2018, 神経眼科, 35(増補1) (増補1), 79 - 79, Japanese


• Vasculitis with superior ophthalmic vein thrombosis compatible with neuro-neutrophilic disease.

  Mari Sakamoto, Takuji Kurimoto, Sotaro Mori, Kaori Ueda, Yukako Keshi, Yuko Yamada, Atsushi Azumi, Taro Shimono, Makoto Nakamura

  Aug. 2018, American journal of ophthalmology case reports, 12

  Scientific journal


• 緑内障眼における他覚的・自覚的機能検査結果とEn Face slab画像を用いた構造評価結果の相関性の検討

  井上 結香子, 鎌田 誠子, 盛 崇太朗, 上田 香織, 坂本 麻里, 栗本 拓治, 山田 裕子, 中村 誠

  眼科臨床紀要会, Jul. 2018, 眼科臨床紀要, 11(7) (7), 555 - 555, Japanese


• Effectiveness and safety of sulcus fixation of Baerveldt glaucoma implants in glaucomatous eyes in patients who underwent multiple intraocular surgeries.

  Sotaro Mori, Mari Sakamoto, Takuji Kurimoto, Akiyasu Kanamori, Kaori Ueda, Yukako Inoue, Yuko Yamada, Makoto Nakamura

  Lead, Jun. 2018, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 256(10) (10)

  Scientific journal


• Short-term effect of additional apheresis on visual acuity changes in patients with steroid-resistant optic neuritis in neuromyelitis optica spectrum disorders.

  Sotaro Mori, Takuji Kurimoto, Kaori Ueda, Makoto Nakamura

  Lead, May 2018, Japanese journal of ophthalmology, 62(4) (4)

  Scientific journal


• Optic Neuritis Possibly Induced by Anti-PD-L1 Antibody Treatment in a Patient with Non-Small Cell Lung Carcinoma.

  Sotaro Mori, Takuji Kurimoto, Kaori Ueda, Hiroko Enomoto, Mari Sakamoto, Yukako Keshi, Yuko Yamada, Makoto Nakamura

  Lead, May 2018, Case reports in ophthalmology, 9(2) (2)

  Scientific journal


• 緑内障眼における他覚的・自覚的機能検査結果とen face slab画像を用いた構造評価結果の相関性の検討

  井上 結香子, 鎌田 誠子, 盛 崇太朗, 上田 香織, 坂本 麻里, 栗本 拓治, 山田 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2018, 日本眼科学会雑誌, 122(3) (3), 252 - 253, Japanese


• アクアポリン9遺伝子欠損マウスにおける視神経挫滅後の網膜神経節細胞死

  盛 崇太朗, 栗本 拓治, 三木 明子, 楠原 仙太郎, 金森 章泰, 中村 誠

  (公財)日本眼科学会, Mar. 2018, 日本眼科学会雑誌, 122(臨増) (臨増), 166 - 166, Japanese

  [Refereed]


• Excessive scleral shrinkage, rather than choroidal thickening, is a major contributor to the development of hypotony maculopathy after trabeculectomy.

  Mari Sakamoto, Yoshiko Matsumoto, Sotaro Mori, Kaori Ueda, Yukako Inoue, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura

  Jan. 2018, PloS one, 13(1) (1)

  Scientific journal


• Diagnostic utility of combined retinal ganglion cell count estimates in Japanese glaucoma patients.

  Mari Sakamoto, Sotaro Mori, Kaori Ueda, Azusa Akashi, Yukako Inoue, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura

  Oct. 2017, Japanese journal of ophthalmology, 62(1) (1)

  Scientific journal


• 下垂体腫瘍患者における光干渉断層計と静的視野検査および多局所視覚誘発電位の異常検出の一致性

  井上 結香子, 盛 崇太朗, 上田 香織, 坂本 麻里, 栗本 拓治, 金森 章泰, 山田 裕子, 中村 誠

  眼科臨床紀要会, Jul. 2017, 眼科臨床紀要, 10(7) (7), 585 - 586, Japanese


• [Home Monitoring of Intraocular Pressure and it's Diurnal Patterns Using Icare® HOME].

  Mari Sakamoto, Akiyasu Kanamori, Sotaro Mori, Kaori Ueda, Yukako Inoue, Takuji Kurimoto, Yuko Yamada, Makoto Nakamura

  Purpose: To evaluate Icare® HOME for home monitoring of intraocular pressure (IOP) and to observe diurnal IOP patterns for a short term. Patients and methods: Twenty six eyes of 16 patients with open angle glaucoma were included. After instruction and practice in using Icare® HOME, patients were asked to measure their IOP by themselves at home or in a sick room. Patients measured their IOP four times a day with a four hour interval between each measurement for three days. Patients repeated measurements until three successful measurements were obtained at each time. Intra-rater reliability was assessed calculating intraclass correlation coefficient (ICC) of the three measurements. Diurnal IOP patterns were assessed for three days. Results: No adverse events occurred. ICC of three measurements was 0.76 (95% confidence coefficient; 0.71 to 0.81). The median of the difference between the highest and the lowest IOP during a day was 4.26 mmHg (95% CI; 4.06 to 4.67). Repeatable patterns were not found in diurnal IOP for three days. Three out of ten patients who answered the questionnaire after measurements found difficulties in handling the device. Conclusions: Although Icare® HOME is safe and could be used for home monitoring of IOP, some patients had difficulties in using the instrument. Diurnal IOP patterns did not show repeatability during a short term.

  Apr. 2017, Nippon Ganka Gakkai zasshi, 121(4) (4), 366 - 72, Japanese, Domestic magazine

  Scientific journal


• Impact of the anti-aquaporin-4 autoantibody on inner retinal structure, function and structure-function associations in Japanese patients with optic neuritis.

  Yoshiko Matsumoto, Sotaro Mori, Kaori Ueda, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Ichiro Nakashima, Makoto Nakamura

  Feb. 2017, PloS one, 12(2) (2)

  Scientific journal


• 抗AQP4抗体陽性視神経炎に対する血液浄化療法の治療効果

  盛 崇太朗, 栗本 拓治, 坂本 麻里, 上田 香織, 井上 結香子, 千原 典夫, 金森 章泰, 山田 裕子, 中村 誠

  日本神経眼科学会, Oct. 2016, 神経眼科, 33(増補1) (増補1), 86 - 86, Japanese

  [Refereed]


• Lamellar hole associated epiretinal proliferationの有無と全層黄斑円孔の術後成績

  今井 尚徳, 大塚 慶子, 石濱 佳奈, 西崎 雅也, 中村 賢和, 安田 絵里子, 上西 衛, 盛 崇太朗, 原 ルミ子, 勝山 敦子, 安積 淳, 中村 誠

  (公財)日本眼科学会, Mar. 2016, 日本眼科学会雑誌, 120(臨増) (臨増), 280 - 280, Japanese

  [Refereed]

• 炎症・感染とこれからの眼科診療 眼炎症を克服するための精密医療の実現に向けて

  楠原 仙太郎, 松宮 亘, 吉川 敦子, 淺原 俊一郎, 木戸 良明, 小川 渉, 西庄 龍東, 曽谷 尭之, 岸 真椰, 橘 吉寿, 内匠 透, 金 景佑, 村井 佑輔, 荒井 美奈, 坂本 麻里, 盛 崇太朗, 牧 仁美, 今井 尚徳, 田上 瑞記, 園田 康平, 蕪城 俊克, 柳井 亮二, 丸山 和一, 金子 優, 篠原 正和, 浅井 義之, 中津井 雅彦, 早野 崇英, 柏木 賢治, 中村 誠

  (公財)日本眼科学会, Mar. 2024, 日本眼科学会雑誌, 128(3) (3), 234 - 255, Japanese


• 高濃度フィブリノーゲンによるICAM-1経路を介した網膜組織傷害の検討

  曽谷 育之, 今井 尚徳, 山田 裕子, 北村 萌, 盛 崇太朗, 松宮 亘, 三木 明子, 楠原 仙太郎, 中村 誠

  (公財)日本眼科学会, Mar. 2024, 日本眼科学会雑誌, 128(臨増) (臨増), 174 - 174, Japanese


• 【先端医療を先取りしよう-日本にはない海外の医療】新しい緑内障手術デバイス

  盛 崇太朗

  (株)医学書院, Feb. 2024, 臨床眼科, 78(2) (2), 216 - 220, Japanese


• 手術手技のコツ 強膜ポケット法を用いた経毛様体扁平部ロングチューブシャント手術

  盛 崇太朗

  (公社)日本眼科手術学会, Jan. 2024, 眼科手術, 37(1) (1), 73 - 76, Japanese


• 傾向スコアを使用した疑似ランダム化比較研究 TramTrac Studyを題材に

  盛 崇太朗

  (公財)日本眼科学会, Nov. 2023, 日本眼科学会雑誌, 127(11) (11), 1039 - 1049, Japanese


• 線維柱帯切開術(眼内法)術後早期に施行された線維柱帯切除術の術後1年成績

  岡 隼生, 坂本 麻里, 荒井 実奈, 高野 史生, 盛 崇太朗, 上田 香織, 中西 裕子, 中村 誠

  日本緑内障学会, Sep. 2023, 日本緑内障学会抄録集, 34回, 160 - 160, Japanese


• 原発開放隅角緑内障と血清・前房水乳酸濃度の関連についての検討

  荒井 実奈, 高野 史生, 盛 崇太朗, 上田 香織, 坂本 麻里, 中西 裕子, 金森 章泰, 前田 秀高, 三木 貴子, 内藤 知子, 尾上 弘光, 廣岡 一行, 河野 通大, 杉原 一暢, 谷戸 正樹, 中村 誠

  日本緑内障学会, Sep. 2023, 日本緑内障学会抄録集, 34回, 197 - 197, Japanese


• 本邦におけるMIGS update

  盛 崇太朗

  (公財)日本眼科学会, Mar. 2023, 日本眼科学会雑誌, 127(臨増) (臨増), 129 - 129, Japanese


• Trabectomeに対するMicrohookの非劣性 TramTrac研究(Noninferiority of Microhook to Trabectome(TramTrac Study))

  盛 崇太朗

  (公財)日本眼科学会, Mar. 2023, 日本眼科学会雑誌, 127(臨増) (臨増), 167 - 167, English


• マイクロフックトラベクロトミー(μTLO)の1年後成績への術前緑内障点眼の影響

  昭原 郁仁, 盛 崇太朗, 奥田 実奈, 高野 史生, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2023, 日本眼科学会雑誌, 127(臨増) (臨増), 218 - 218, Japanese


• 【神経眼科疾患と鑑別が必要な疾患】緑内障に隠れた神経眼科疾患の見つけ方

  盛 崇太朗

  日本神経眼科学会, Mar. 2023, 神経眼科, 40(1) (1), 17 - 23, Japanese


• 線維柱帯切除術後の早期濾過胞機能不全に対するマイトマイシンC併用濾過胞再建術の術後3年成績

  増田 理沙, 坂本 麻里, 昭原 郁仁, 奥田 実奈, 高野 史生, 盛 崇太朗, 上田 香織, 栗本 拓治, 金森 章泰, 中西 裕子, 中村 誠

  日本緑内障学会, Sep. 2022, 日本緑内障学会抄録集, 33回, 101 - 101, Japanese


• 早期緑内障に対する外科的治療の意義と課題

  盛 崇太朗

  日本緑内障学会, Sep. 2022, 日本緑内障学会抄録集, 33回, 136 - 136, Japanese


• 当院で経験した虹彩分離症5症例の臨床的特徴

  昭原 郁仁, 上田 香織, 奥田 実奈, 高野 史生, 盛 崇太朗, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  日本緑内障学会, Sep. 2022, 日本緑内障学会抄録集, 33回, 146 - 146, Japanese


• マイクロフックトラベクロトミー(μTLO)の術成績に対する術前リパスジル点眼投与の影響

  奥田 実奈, 盛 崇太朗, 昭原 郁仁, 高野 史生, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  日本緑内障学会, Sep. 2022, 日本緑内障学会抄録集, 33回, 154 - 154, Japanese


• 緑内障患者に対する点眼補助具(Just in)の使用感アンケート調査

  江本 美佐, 坂本 麻里, 曽谷 尭之, 高野 史生, 村井 祐輔, 西庄 龍東, 盛 崇太朗, 大塚 尚美, 高木 泰孝, 堀 清貴, 中村 誠

  (株)メディカル葵出版, Jun. 2022, あたらしい眼科, 39(6) (6), 808 - 813, Japanese


• 緑内障患者におけるアイモ両眼ランダム測定の再現性の検討

  豊国 秀昭, 坂本 麻里, 奥田 実奈, 高野 史生, 村井 佑輔, 盛 崇太朗, 上田 香織, 栗本 拓治, 中西 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2022, 日本眼科学会雑誌, 126(臨増) (臨増), 172 - 172, Japanese


• 緑内障患者に対する点眼補助具(Just in)の使用感アンケート調査

  江本 美佐, 坂本 麻里, 曽谷 尭之, 高野 史生, 村井 佑輔, 西庄 龍東, 盛 崇太朗, 大塚 尚美, 高木 泰孝, 堀 清貴, 中村 誠

  日本緑内障学会, Sep. 2021, 日本緑内障学会抄録集, 32回, 87 - 87, Japanese


• TrabectomeとMicrohook線維柱帯切開術術後成績を比較する多施設後ろ向き観察研究

  盛 崇太朗, 庄司 信行, 谷戸 正樹, 横山 悠, 亀田 隆範, 庄司 拓平, 溝上 志朗, 齋藤 雄太, 石田 恭子, 植田 俊彦, 中村 誠

  日本緑内障学会, Sep. 2021, 日本緑内障学会抄録集, 32回, 132 - 132, Japanese


• ロングチューブシャント術後の被膜除去術の短期成績

  奥田 実奈, 盛 崇太朗, 高野 史生, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  日本緑内障学会, Sep. 2021, 日本緑内障学会抄録集, 32回, 136 - 136, Japanese


• 多発性硬化症の病態評価における光干渉断層計(OCT)の意義についての検討

  赤谷 律, 千原 典夫, 古東 秀介, 盛 崇太朗, 栗本 拓治, 立花 久嗣, 大塚 喜久, 上田 健博, 関口 兼司

  (一社)日本神経学会, Nov. 2019, 臨床神経学, 59(Suppl.) (Suppl.), S309 - S309, Japanese


• 髄膜炎を伴う続発性眼窩炎症と強膜炎を呈した汎発性帯状疱疹の1例

  佐々木 信之, 坂本 麻里, 栗本 拓治, 盛 崇太郎, 上田 香織, 中西 裕子, 飯島 健太, 立花 久嗣, 中村 誠

  日本神経眼科学会, Nov. 2018, 神経眼科, 35(増補1) (増補1), 87 - 87, Japanese

• これさえ学べば死角なし!視野フロンティア

  槃木悠人, 盛 崇太朗

  Contributor, 視神経疾患, P201-204, 文光堂, Apr. 2024, Japanese, ISBN: 9784830656262


• 神経眼科はじめの一歩

  高野史生, 盛 崇太朗

  Contributor, 栄養欠乏性視神経症、中毒性視神経症, P55-59, 文光堂, Oct. 2023, Japanese, ISBN: 9784830656231


• スッキリわかる緑内障の検査と診断

  盛 崇太朗

  Contributor, ゴールドマン視野検査 P114-118, 文光堂, Apr. 2022, Japanese, ISBN: 9784830656118


• 眼科鑑別診断実力アップQ&A : 専門医必携

  盛 崇太朗

  Contributor, 神経眼科 視神経疾患, P267-272,, 南江堂, Feb. 2021, Japanese, ISBN: 9784524249619

• Optic Neuritis in Pediatric and Adult Populations

  Sotaro Mori

  第129回日本眼科学会総会, Apr. 2025

  [Invited]


• 手術と外来の二面から緑内障診療を再考する

  盛 崇太朗

  第81回 愛媛県眼科集談会, Apr. 2025

  [Invited]


• 手術から見えてきた新しい緑内障戦略

  盛 崇太朗

  緑内障治療講演会 in 山口, Feb. 2025

  [Invited]


• 緑内障を巡るデータが語る理論、患者が語る現実

  盛 崇太朗

  きさらぎ眼科セミナー2025, Jan. 2025

  [Invited]


• 左右差から考える緑内障

  盛 崇太朗

  第26回兵庫県眼科フォーラム, Nov. 2024

  [Invited]


• 新たな緑内障病態とMIGSの未来

  盛 崇太朗

  中四国緑内障WEB講演会, Oct. 2024

  [Invited]


• MIGSを巡る新たな病態理解

  盛 崇太朗

  Glaucoma Expert Meeting in 北海道, Oct. 2024

  [Invited]


• 神戸発、緑内障管理の新たなアプローチ

  盛 崇太朗

  緑内障治療フォーラム in 金沢, Oct. 2024

  [Invited]


• 目がダブる？複視について知ろう

  盛 崇太朗

  神戸市 目の愛護デー 目の健康講座, Oct. 2024

  [Invited]


• Optimising Outcomes with MIGS through Two Novel Hypotheses

  盛 崇太朗

  第35回日本緑内障学会, Japan-Asia Symposium, Sep. 2024

  [Invited]

  Nominated symposium


• 緑内障を巡る新たな病態仮説：廃用性萎縮と混合型緑内障

  盛 崇太朗

  2024年度岩手学術セミナー, Sep. 2024

  [Invited]


• マイクロフック

  盛 崇太朗

  第39回JSCRS学術総会, 教育セミナー「白内障とMIGS」, Jun. 2024

  [Invited]

  Nominated symposium


• 神戸発、データで魅せる緑内障手術の動向と展望

  盛 崇太朗

  第20回山陰緑内障フォーラム, Jun. 2024

  [Invited]


• HFAを用いた緑内障の見分け方

  盛 崇太朗

  第13回日本視野画像学会学術集会, JIPSコーチングセミナー, Jun. 2024

  [Invited]

  Public discourse


• What's new in UK? Real-time imaging of cellular apoptosis

  盛 崇太朗

  第34回日本緑内障学会, Global Symposium, Sep. 2023

  [Invited]

  Nominated symposium


• 緑内障手術の最適化のためのアポトーシス可視化技術の実践的応用

  盛 崇太朗

  第34回日本緑内障学会, 学会長企画 新進気鋭の緑内障研究者の競演:Competition among up-and-coming glaucoma investigators, Sep. 2023

  Public symposium


• 本邦におけるMIGS update

  盛 崇太朗

  第127回日本眼科学会総会, サブスペシャリティサンデー ③緑内障治療update -新たな術式と治療成績-, Jun. 2023

  [Invited]

  Nominated symposium


• Noninferiority of Microhook to Trabectome (TramTrac Study)

  第127回日本眼科学会総会, The International Crosstalk Symposium by Young Ophthalmologists, Apr. 2023

  [Invited]

  Nominated symposium


• 早期緑内障に対する外科的治療の意義と課題

  盛 崇太朗

  第33回日本緑内障学会 シンポジウム: テーマ「緑内障早期診断・治療の意義と課題」, Sep. 2022

  [Invited]

  Nominated symposium


• 網膜神経節細胞におけるエネルギー基質輸送の意義

  盛 崇太朗

  第31回日本緑内障学会, シンポジウム: テーマ「緑内障のNeuroscience」, Oct. 2020

  [Invited]

  Nominated symposium


• マイクロペリメトリー, MP-3

  盛 崇太朗

  第30回日本緑内障学会, シンポジウム テーマ「緑内障検査: 独自の視点から新たな知見を得る」, Sep. 2019

  [Invited]

  Nominated symposium

• 緑内障手術最適化を目指した眼内経路劣化の解明

  盛 崇太朗

  日本学術振興会, 科学研究費助成事業, 若手研究, 神戸大学, Apr. 2024 - Mar. 2029


• Proposal of a novel pathomechanism of glaucomatous optic neuropathy as dysregulated lactate shuttle and signal transduction and exploration of treatment

  中村 誠, 坂本 麻里, 楠原 仙太郎, 目黒 明, 盛 崇太朗, 真田 昌爾

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2024 - 31 Mar. 2027


• 眼内細胞機能のリアルタイム可視化を目指した前眼部OCT技術の開発

  神戸大学, 2025年度「 神戸大学ＧＡＰファンドプログラム（うりぼーファンド）」, 神戸大学, Apr. 2025 - Mar. 2026, Principal investigator