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WADA Norihito
Center for Advanced Medical Engineering Research &Development (CAMED)
Associate Professor

  • Profile

    Assistant Professor Department of Surgery A member of Upper GI Surgery Group Hernia Outpatient Consultant

Researcher basic information

■ Research Keyword
  • Surgery
■ Research Areas
  • Life sciences / Digestive surgery / Digestive Organ Surgery
  • Life sciences / General surgery, pediatric surgery

Research activity information

■ Paper
  • Kondo T, Okabayashi K, Sugiura K, Obara H, Takeuchi H, Wada N, Takano Y, Iwata S, Hasegawa N, Kitagawa Y
    Journal of Infection and Chemotherapy, Dec. 2020, Journal of Infection and Chemotherapy, 26(12) (12), 1244 - 1248, English
    Scientific journal

  • Aoyama J, Kawakubo H, Matsuda S, Mayanagi S, Fukuda K, Irino T, Nakamura R, Wada N, Kitagawa Y
    © 2020, The International Gastric Cancer Association and The Japanese Gastric Cancer Association. Background: Laparoscopic and endoscopic cooperative surgery (LECS) technique for gastric submucosal tumor (SMT) has developed, but treatment of SMT on the esophagogastric junction (EGJ) remains technically difficult because excessive resection may result in postoperative transformation of the EGJ and cause stenosis, and intervention to lower esophageal sphincter may result in gastroesophageal reflux. The study aim was to evaluate the feasibility and safety of LECS for SMT on the EGJ. Methods: Between September 2012 and December 2018, LECS was performed for 21 patients with SMTs on the EGJ. Fundoplication was performed after LECS according to the intraoperative findings for each case. The patients’ backgrounds, operative outcomes, and follow-up data, including endoscopic findings of gastroesophageal reflux disease (GERD) and proton pomp inhibitor (PPI) use, were reviewed. Results: In all 21 cases, LECS was completed with a mean operation time of 225 min, and a mean blood loss of 8.8 mL. All patients were alive without recurrence within the mean follow-up period of 30.5 months. Both GERD and PPI use tended to be less frequent when fundoplication was performed, although these differences were not statistically significant. (7.7% vs. 37.5%; P = 0.091, 23.1% vs. 50.0%; P = 0.204, respectively). Conclusions: We demonstrated the feasibility and safety of LECS for SMTs even on the EGJ. Fundoplication after LECS may be an approach for the prevention of postoperative reflux esophagitis. Future research is warranted to validate the efficacy of the addition of fundoplication.
    Gastric Cancer, Nov. 2020, Gastric Cancer, 23(6) (6), 1084 - 1090, English, Domestic magazine
    Scientific journal

  • Takeuchi M, Yokose T, Kawakubo H, Matsuda S, Mayanagi S, Irino T, Fukuda K, Nakamura R, Wada N, Obara H, Kitagawa Y
    © 2020, The Japan Esophageal Society. Background: Presepsin is suggested to be an accurate sepsis diagnostic biomarker, playing an important role in distinguishing infection from no-infection status. However, to date, there is no study determining presepsin’s role in diagnosing post-esophagectomy infectious complications. Methods: Thirty patients who underwent esophagectomy for esophageal carcinoma were included in this prospective observational study. We investigated preoperative presepsin levels’ changes and evaluated the relationship between infectious complications and presepsin levels. Moreover, we analyzed the classification and regression tree (CART) to determine presepsin’s optimal cutoff values for discriminating infectious complications. Results: For 10 patients with infectious complications, median presepsin levels were 168, 337, 303, 271, 314, 978, and 752 pg/ml, pre- and immediately post-surgery, and 1, 2, 3, 5, 7 days post-surgery, respectively. Presepsin levels were significantly higher in the infectious complication group exclusively from preoperation to POD 7 (p = 0.048). Furthermore, area under the curve’s value of presepsin on POD 5 and 7 was higher than the other three biomarkers included for discriminating infectious complications (i.e., procalcitonin, leukocyte, and C-reacted protein). We set an optimal cutoff value for presepsin calculated by CART. Specifically, on POD 5, the cutoff was 888 pg/ml with a sensitivity of 60% and a specificity of 90%, and on POD 7, the cutoff was 668 pg/ml with a sensitivity of 60% and a specificity of 85%. Conclusions: Presepsin levels on POD 5 and 7 after esophagectomy are a valuable indicator of infectious complication’s detection vs. leukocyte, C-reacted protein, and procalcitonin.
    Esophagus, Oct. 2020, Esophagus, 17(4) (4), 399 - 407, English, Domestic magazine
    Scientific journal

  • Ozawa H, Kawakubo H, Kitago M, Mayanagi S, Fukuda K, Nakamura R, Suda K, Wada N, Kitagawa Y
    © 2019 Japan Society for Endoscopic Surgery, Asia Endosurgery Task Force and John Wiley & Sons Australia, Ltd. We report the case of a 70-year-old woman with synchronous advanced esophageal cancer and pancreatic head cancer. To reduce the surgical invasiveness, we performed a two-stage operation that included percutaneous endoscopic gastrostomy and minimally invasive esophagectomy. In the first stage, we performed a percutaneous endoscopic gastrostomy, a thoracoscopic esophagectomy with cervical and mediastinal lymph node dissection, and an esophagostomy without a laparotomy. The second stage, which was performed 28 days after the first operation, consisted of a total gastrectomy, pancreaticoduodenectomy, colonic reconstruction, and jejunostomy. Fifty days after the second operation, the patient was discharged from the hospital. A two-stage operation that includes minimally invasive esophagectomy seems to be useful for avoiding serious postoperative complications, even in patients with rare, synchronous advanced cancers of the esophagus and the pancreatic head.
    Asian journal of endoscopic surgery, Jul. 2020, Asian journal of endoscopic surgery, 13(3) (3), 410 - 414, English, Domestic magazine

  • Maeda Y, Takeuchi H, Matsuda S, Okamura A, Fukuda K, Miyasho T, Nakamura R, Suda K, Wada N, Kawakubo H, Kitagawa Y
    Esophagus, Jul. 2020, Esophagus, 17(3) (3), 279 - 288, English
    Scientific journal

  • Matsunaga T, Ohnishi K, Wada N, Kitagawa Y
    Electrical Engineering in Japan (English translation of Denki Gakkai Ronbunshi), Jun. 2020, Electrical Engineering in Japan (English translation of Denki Gakkai Ronbunshi), 211(1-4) (1-4), 47 - 54, English
    Scientific journal

  • Shimada A, Takeuchi H, Nishi T, Mayanagi S, Fukuda K, Suda K, Nakamura R, Wada N, Kawakubo H, Nakahara T, Kameyama K, Kitagawa Y
    © 2019, The International Gastric Cancer Association and The Japanese Gastric Cancer Association. Background: To safely perform minimized gastrectomy based on sentinel node (SN) concept for early gastric cancer patients, intraoperative diagnostic accuracy is indispensable. This study aimed to evaluate the clinical utility of the one-step nucleic acid amplification (OSNA) assay in the intraoperative diagnosis of SN metastasis in early gastric cancer patients compared with that of histopathological examination. Methods: We conducted a prospective study using the OSNA assay for 43 patients with cT1N0M0 gastric cancer undergoing gastrectomy with SN mapping. All the SNs and selected non-SNs were examined by routine histopathological diagnosis, and the OSNA assay. Results: We performed permanent histopathology (PH) in 1732 lymph nodes (LNs) (286 SNs and 1446 non-SNs) obtained from 43 patients. We also evaluated 439 LNs (286 SNs and 153 non-SNs) with the OSNA assay in addition to PH. Intraoperative histopathology (IH) was performed in 214 LNs (213 SNs and 1 non-SN). PH revealed LN metastasis in 6 patients (14%), all of whom showed positive SNs by PH. The diagnostic accuracy to predict the LN status based on the SN concept by histological examination was 100%. The concordance rate between the OSNA assay and the PH and IH were 0.970 and 0.981 respectively. Discordant results between PH and OSNA assay were observed in 13 LNs. The sensitivity and specificity of the OSNA assay compared with those of PH were 0.636, and 0.988, and compared with those of IH were 0.800, and 0.995. Conclusion: Our results suggest that the OSNA assay is a useful and convenient tool for the intraoperative detection of SN metastasis in early gastric cancer patients.
    Gastric Cancer, May 2020, Gastric Cancer, 23(3) (3), 418 - 425, English, Domestic magazine
    Scientific journal

  • Matsuda S, Kawakubo H, Takeuchi H, Hayashi M, Mayanagi S, Takemura R, Irino T, Fukuda K, Nakamura R, Wada N, Kitagawa Y
    © 2020 BJS Society Ltd Published by John Wiley & Sons Ltd Background: Oesophageal squamous cell carcinoma is an aggressive disease owing to early and widespread lymph node metastases. Multimodal therapy and radical surgery may improve prognosis. Few studies have investigated the efficacy of radical lymph node and thoracic duct resection. Methods: Patients with oesophageal squamous cell carcinoma who underwent transthoracic minimally invasive oesophagectomy (TMIE) for cancer at Keio University Hospital between January 2004 and December 2016 were selected. Between 2004 and 2008, TMIE was performed in the lateral decubitus position without thoracic duct resection (standard TMIE). From 2009 onwards, TMIE with extended lymph node and thoracic duct resection was introduced (extended TMIE). Demographics, co-morbidity, number of retrieved lymph nodes, pathology, postoperative complications and recurrence-free survival (RFS) were compared between groups. Results: Forty-four patients underwent standard TMIE and 191 extended TMIE. There were no significant differences in clinical and pathological tumour stage or postoperative complications. The extended-TMIE group had more lymph nodes removed at nodal stations 106recL and 112. Among patients with cT1 N0 disease, RFS was better in the extended-TMIE group (P < 0·001), whereas there was no difference in RFS between groups in patients with advanced disease. Conclusion: Extended TMIE including thoracic duct resection increased the number of lymph nodes retrieved and was associated with improved survival in patients with cT1 N0 oesophageal squamous cell carcinoma.
    British Journal of Surgery, May 2020, British Journal of Surgery, 107(6) (6), 705 - 711, English, International magazine
    Scientific journal

  • Takeuchi M, Kawakubo H, Shimada A, Matsuda S, Nakahara T, Mayanagi S, Irino T, Fukuda K, Nakamura R, Wada N, Takeuchi H, Kitagawa Y
    © 2019, The International Gastric Cancer Association and The Japanese Gastric Cancer Association. Background: Even though indications for endoscopic resection (ER) in early gastric cancer are determined based on the potential risk of lymph node metastasis, the criteria for ER remain controversial. Sentinel node (SN) mapping for early gastric cancer can help determine regional lymphatic flow patterns. The aim of this study was to assess lymphatic flow according to the SN concept in patients with early gastric cancer, especially those who satisfy the expanded criteria for ER. Methods: We retrospectively enrolled 301 patients diagnosed with pT1 adenocarcinoma who had undergone gastrectomy with SN mapping and had no lymphovascular invasion. Patients were categorized into six groups based on oncological assessment. We analyzed lymphatic flow, including the number of identified SN and SN basin, and the rate of SN metastasis in each group. Results: Of the 301 patients, 128 (42.5%) met the criteria for ER, with 18 in the absolute group and 110 in the expanded group; 173 (57.5%) were assigned to the surgical group. SN metastasis rate tended to be higher in surgical group patients than in ER criteria patients. In the expanded criteria group, the sub-group of patients with intramucosal, undifferentiated adenocarcinoma measuring 20 mm or less had a significantly greater number of identified SNs (p = 0.013) and SN basins (p = 0.032). Furthermore, SN metastasis was observed only in this group. Conclusions: Patients with intramucosal, nonulcerated, undifferentiated adenocarcinoma measuring 20 mm or less could develop a lymphatic network. For these patients, careful follow-up is required after ER.
    Gastric Cancer, May 2020, Gastric Cancer, 23(3) (3), 531 - 539, English, Domestic magazine
    Scientific journal

  • Takahashi M, Fukuda K, Saikawa Y, Nakamura R, Wada N, Kawakubo H, Takeuchi H, Kitagawa Y
    Anticancer Research, Apr. 2020, Anticancer Research, 40(4) (4), 1921 - 1930, English
    Scientific journal

  • Matsuda S, Takeuchi H, Kawakubo H, Takemura R, Maeda Y, Hirata Y, Kaburagi T, Egawa T, Nishi T, Ogura M, Miyasho T, Okamura A, Mayanagi S, Fukuda K, Nakamura R, Irino T, Wada N, Kitagawa Y
    © 2020, Society of Surgical Oncology. Purpose: To arrange multidisciplinary treatment for esophageal cancer, a simple and accurate predictive marker for prognosis is required. The current multicenter prospective study aims to validate the prognostic significance of fibrinogen and albumin score (FA score) for esophageal cancer patients. Patients and Methods: Patients who were planned to undergo surgical resection for esophageal cancer at four participating institutions were enrolled in this study. Patient background, clinicopathological factors, and blood concentration of plasma fibrinogen and albumin were collected. Patients with elevated fibrinogen and decreased albumin levels were allocated a score of 2; those with only one of these abnormalities were allocated a score of 1; and those with neither of these abnormalities were allocated a score of 0. Recurrence-free survival (RFS) and overall survival (OS) were evaluated as a primary endpoint. Results: From four participating institutions, 133 patients were registered for the current analysis. The distribution of FA score of 0/1/2 was 84 (63%)/34 (26%)/15 (11%), respectively. In the analysis of primary endpoint, the preoperative FA score significantly classified RFS (FA score 1/2: HR 2.546, p = 0.013/6.989, p < 0.001) and OS (FA score 1/2: HR 2.756, p = 0.010/6.970, p < 0.001). We further evaluated the prognostic significance of FA score under stratification by pStage. As a result, with increasing FA score, RFS and OS were significantly worse in both pStage 0–I and II–IV groups. Conclusions: The prognostic impact of preoperative FA score was confirmed for esophageal cancer patients in the current multicenter prospective trial. FA score can be considered to predict postoperative survival and rearrange the treatment strategy before esophagectomy.
    Annals of Surgical Oncology, 2020, Annals of Surgical Oncology, 28(2) (2), 774 - 784
    Scientific journal

  • Takaya K, Aramaki-Hattori N, Yabuki H, Wada N, Sakai S, Okabe K, Kishi K
    © 2020 Kento Takaya et al. Introduction. We report a case of diastasis rectus abdominis (DRA), in which the improvement of the appearance was obtained by performing extra skin resection. Case Report. A 30-year-old woman presented persistent abdominal bulging after her second delivery. She was diagnosed as DRA by computed tomography. We underwent a surgery that tacking the anterior layer of the rectus sheath and resecting excess skin. Results. There has been no clinical evidence of recurrence, and the patient satisfies her abdominal appearance. Conclusion. Because DRA is not a true hernia, surgery for DRA should be performed in understanding how patients want to improve their aesthetic appearance.
    Case Reports in Medicine, 2020, Case Reports in Medicine, 2020, 7635801 - 7635801, English, International magazine

  • Hayashi M, Takeuchi H, Nakamura R, Suda K, Wada N, Kawakubo H, Kitagawa Y
    © 2019, The Japan Esophageal Society. Background: Esophagectomy is associated with a high risk of postoperative complications, and the respiratory complications are the most common. Therefore, stratification of patients based on preoperative risk factors is essential. This study aimed to identify the risk of postoperative pneumonia (POP) based on the preoperative factors and determine the optimal perioperative surgical management strategy. Methods: This retrospective study involved 207 patients who underwent esophagectomy. The patients were divided into two groups, namely, with POP and without POP. To identify the risk factors for POP, the pre- and perioperative characteristics were analyzed. A receiver operating characteristics curve was used to determine a cutoff value of 2.40 L for the forced expiratory volume in 1 s (FEV1.0) and the cohort was divided into a high- and low-FEV1.0 group. A second analysis was then performed to determine the optimal surgical management for patients at a high risk for POP. Results: POP occurred in 45 (21.7%) patients. A multiple logistic regression analysis showed that FEV1.0 was significantly lower in the POP (+) group (P = 0.020); thus, a low FEV1.0 was found to be a risk factor for POP. Multiple logistic regression analysis showed that open thoracotomy was a significant risk factor for POP in low FEV1.0 patients (P = 0.013). Conclusions: A low FEV1.0 and an open thoracotomy are risk factors for POP. Therefore, patients with low FEV1.0 should be managed carefully and video-assisted thoracic surgery should be considered.
    Esophagus, Jan. 2020, Esophagus, 17(1) (1), 50 - 58, English, Domestic magazine
    Scientific journal

  • Inomata M, Shiroshita H, Uchida H, Bandoh T, Akira S, Yamaguchi S, Kurokawa Y, Seki Y, Eguchi S, Wada N, Takiguchi S, Ieiri S, Endo S, Iwazaki M, Sato Y, Tamaki Y, Kitamura K, Tabata M, Kanayama H, Mimata H, Hasegawa T, Takahashi H, Onishi K, Uemura T, Hashizume M, Matsumoto S, Kitano S, Watanabe M
    © 2019 Japan Society for Endoscopic Surgery, Asia Endosurgery Task Force and John Wiley & Sons Australia, Ltd. In Japan, the first endoscopic surgery, a laparoscopic cholecystectomy, was performed in 1990. Since then, operative procedures have been standardized, and the safety and efficacy of endoscopic surgery have been evaluated. In accordance with the social acceptance of endoscopic surgery as a less invasive type of surgery, the number of endoscopic procedures performed has increased in all surgical domains. The Japan Society for Endoscopic Surgery (JSES) has played an important role in the development of endoscopic surgery in Japan. Notably, a technical skills certification system for surgeons was established by the JSES to train instructors on how to teach safe endoscopic surgery. Furthermore, the JSES has conducted a national survey every two years to evaluate the status of endoscopic surgery over time. In 2017, 248 743 patients underwent endoscopic surgery in all surgical domains, such as abdominal, thoracic, mammary and thyroid gland, cardiovascular, obstetrics and gynecology, urologic, orthopedic, and plastic surgery. The 14th National Survey of Endoscopic Surgery conducted by the JSES demonstrated the status of laparoscopic surgery in Japan in 2016-2017.
    Asian journal of endoscopic surgery, Jan. 2020, Asian journal of endoscopic surgery, 13(1) (1), 7 - 18, English, Domestic magazine
    Scientific journal

  • Aoyama J, Goto O, Kawakubo H, Mayanagi S, Fukuda K, Irino T, Nakamura R, Wada N, Takeuchi H, Yahagi N, Kitagawa Y
    Jan. 2020, Gastric Cancer, 23(1) (1), 154 - 159, English
    Scientific journal

  • Nishida T, Sakai Y, Takagi M, Ozaka M, Kitagawa Y, Kurokawa Y, Masuzawa T, Naito Y, Kagimura T, Hirota S, Saito T, Komatsu Y, Kondo M, Hayashi T, Gotoda N, Takiguchi N, Maki A, Baba H, Orita H, Yabusaki H, Chiguchi G, Manaka D, Nabeshima K, Akabane H, Ono K, Wada N, Kaji M, Yoshida K, Takahashi I, Fujitani K, Matsumoto S, Tamamori Y, Saito H, Ueda S, Yamamura M, Fujii H, Yoshino S, Suzuki A, Otsuji E, Kawachi S, Takahashi T, Muguruma K, Ishikawa S, Mits
    Gastric Cancer, Jan. 2020, Gastric Cancer, 23(1) (1), 118 - 125
    Scientific journal

  • Hayashi M, Kawakubo H, Fukuda K, Mayanagi S, Nakamura R, Suda K, Hayashida T, Wada N, Kitagawa Y
    © 2019 John Wiley & Sons, Ltd. Background: Although chemotherapy is a core treatment for esophageal cancer, some patients develop drug resistance. Gene screening with transposons (i.e. mobile genetic elements) is a novel procedure for identifying chemotherapy-resistant genes. Transposon insertion can randomly affect nearby gene expression. By identifying the affected genes, candidate genes can be found. The present study aimed to identify cisplatin (CDDP)/5-fluorouracil (5-FU)-resistant genes in in vitro human esophageal squamous cell carcinoma with transposons. Methods: After establishing transposon-tagged cells, we obtained CDDP/5-FU-resistant colonies. A polymerase chain reaction and sequencing were used to identify the transposon inserted site and candidate CDDP/5-FU resistant genes. Focusing on one candidate gene, we confirmed CDDP/5-FU resistance by comparing the IC50 between drug-resistant and wild-type cells. Furthermore, we investigated gene expression by a real-time polymerase chain reaction. Finally, we mediated the candidate gene level with small interfering RNA to confirm the resistance. Results: Thirty-nine candidate genes for CDDP/5-FU resistance were identified. Nineteen were for CDDP resistance and 27 were for 5-FU resistance. Seven genes, THUMP domain-containing protein 2 (THUMPD2), nuclear factor interleukin-3-regulated protein (NFIL3), tyrosine-protein kinase transmembrane receptor 2 (ROR2), C-X-C chemokine receptor type 4 (CXCR4), thrombospondin type-1 domain-containing protein 2 (THSD7B) alpha-parvin (PARVA) and TEA domain transcription factor 1 (TEAD1), were detected as candidate genes in both colonies. Regarding THUMPD2, its expression was downregulated and knocking down THUMPD2 suggested drug resistance in both drugs. Conclusions: Thirty-nine candidate genes were identified with transposons. The downregulation of THUMPD2 was suggested to play a role in multidrug resistance in in vitro esophageal squamous cell carcinoma.
    Journal of Gene Medicine, Dec. 2019, Journal of Gene Medicine, 21(12) (12), e3135, English, International magazine
    Scientific journal

  • Saito Y, Kawakubo H, Takami H, Aoyama J, Mayanagi S, Irino T, Fukuda K, Suda K, Nakamura R, Wada N, Kitagawa Y
    © 2019, Society of Surgical Oncology. Background: Cervical esophageal cancer (CEC) patients whose larynx function cannot be preserved often undergo chemoradiotherapy, whereas those with residual or recurrent lesions undergo a pharyngo-laryngo-esophagectomy (PLE); however, some need to undergo a pharyngolaryngectomy with total esophagectomy (PLTE) for synchronous or metachronous esophageal cancer. We retrospectively evaluated the relationship between preoperative irradiation (or the extent of esophageal resection) and postoperative endocrine complications in CEC, including hypothyroidism and hypoparathyroidism. Methods: The cancers of 35 (5.4%) of 678 esophageal cancer patients with esophagectomy treated in 2000–2017 were CECs. We also analyzed the 17 cases of CEC patients who underwent PLE with thyroid lobectomy—11 with irradiation before PLE and 6 without irradiation. Seven patients underwent a PLTE. Results: Hypothyroidism and hypoparathyroidism occurred in 14 and 12 patients, respectively. The hypothyroidism rate was significantly higher in patients with irradiation versus those without irradiation (100% vs. 50%; p = 0.010), and the hypoparathyroidism rate was significantly higher in the PLTE versus non-PLTE patients (100% vs. 50%; p = 0.026). The mean levothyroxine dosage was 1.60 μg/kg/day in the PLE patients post-irradiation. Conclusions: Irradiation appears to be a risk factor for hypothyroidism after PLE with thyroid lobectomy, while PLTE might have some effect on hypoparathyroidism. Due to vocal function loss, PLE patients may experience symptoms from endocrine complications. Levothyroxine treatment soon after PLE for post-irradiation patients and patients requiring as-needed calcium or vitamin D supplementation based on biochemical hypocalcemia for PLE (especially PLTE), may be effective in preventing symptomatic endocrine complications.
    Annals of Surgical Oncology, Oct. 2019, Annals of Surgical Oncology, 26(11) (11), 3711 - 3717, English, International magazine
    Scientific journal

  • Hayashi M, Kawakubo H, Mayanagi S, Nakamura R, Suda K, Wada N, Kitagawa Y
    © 2019, The Japan Esophageal Society and Springer. Background: The surgical Apgar score (SAS) has been a useful predictor of postoperative complications in several types of cancer. However, there are few reports about the correlation of SAS and esophageal cancer. This study aimed to examine the utility of SAS as a predictor of major complications, particularly anastomotic leakage, in patients who underwent transthoracic esophagectomy, and investigate the correlation between SAS and patient prognosis. Methods: This is a single-center, retrospective observational study. A total of 190 patients who underwent esophagectomy for esophageal cancer in 2012–2016 were reviewed to find the correlation between SAS and postoperative complications (Clavien–Dindo classification III or higher). SAS was calculated based on intraoperative estimated blood loss, lowest mean arterial pressure, and lowest heart rate. Major complications included anastomotic leakage, respiratory, cardiac, recurrent nerve palsy, chylothorax, and other complications. We also reviewed how SAS was correlated with 3 year overall survival (OS) and recurrence-free survival (RFS). A high SAS was defined as ≥ 6, and a low SAS as < 6. Results: On univariate analysis, SAS showed a statistical significance in all major complications and anastomotic leakage. On multiple logistic regression analysis, a low SAS was detected as a risk factor of the major complications and anastomotic leakage, with a significant difference. Moreover, we conducted survival analysis with SAS; however, we could not detect that a low SAS had a negative impact on OS and RFS. Conclusions: A low SAS can be a predictor of postoperative complications, especially anastomotic leakage. However, SAS was not correlated with OS or RFS.
    Esophagus, Oct. 2019, Esophagus, 16(4) (4), 386 - 394, English, Domestic magazine
    Scientific journal

  • Aoyama J, Kawakubo H, Mayanagi S, Fukuda K, Irino T, Nakamura R, Wada N, Suzuki T, Kameyama K, Kitagawa Y
    Annals of Surgical Oncology, Sep. 2019, Annals of Surgical Oncology, 26(9) (9), 2874 - 2881, English
    Scientific journal

  • Takeuchi M, Kawakubo H, Mayanagi S, Yoshida K, Irino T, Fukuda K, Nakamura R, Wada N, Takeuchi H, Kitagawa Y
    World Journal of Surgery, Aug. 2019, World Journal of Surgery, 43(8) (8), 2006 - 2015, English
    Scientific journal

  • Takeuchi M, Kawakubo H, Mayanagi S, Suzuki Y, Okabayashi K, Yamashita T, Kamiya S, Irino T, Fukuda K, Nakamura R, Suda K, Wada N, Takeuchi H, Kitagawa Y
    © 2018, The International Gastric Cancer Association and The Japanese Gastric Cancer Association. Background: Although some predictive factors of long-term survival after a distal gastrectomy for gastric cancer have been reported, only few studies have predicted long-term outcomes based on preoperative parameters. We aimed to evaluate the reliability of perioperative risk calculator for predicting overall survival (OS) after distal gastrectomy in patients with gastric cancer. Methods: Overall, 337 patients (225 males, 112 females) who had undergone a distal gastrectomy for gastric cancer at the Keio University Hospital, Tokyo, Japan, between January 2009 and December 2013 were enrolled in this study. We investigated the reliability of a risk calculator for the prediction of OS. Results: In multivariate analysis, the risk models for operative mortality and 30-day mortality were identified as predictors of death. Time-dependent receiver operating characteristics (ROC) curve analysis indicated that the estimated area under the curve (AUC) value of the risk model for operative mortality was > 0.870 during the first postoperative 3 years. We set optimal cutoff values of the risk model operative mortality for OS using the Cutoff Finder online tool. The cutoff values of 4.117% were significant risk factors of death. Similar results were observed in the external validation set. Conclusions: We elucidated the associations among risk calculator values and OS rates of patients with gastric cancer. Time-dependent ROC curve analysis suggested that the AUC value of the risk model for operative mortality was high, indicating that this risk calculator would be useful for not only short-term outcomes, but also long-term outcomes.
    Gastric Cancer, May 2019, Gastric Cancer, 22(3) (3), 624 - 631, English, Domestic magazine
    Scientific journal

  • Takeuchi M, Obara H, Kawakubo H, Shinoda M, Okabayashi K, Mayanagi S, Irino T, Fukuda K, Nakamura R, Wada N, Kitago M, Yagi H, Abe Y, Oshima G, Hori S, Tsuruta M, Ishida T, Yokose T, Hirukawa K, Isobe Y, Sekimoto Y, Harada H, Maeda Y, Shito M, Kondo T, Sato Y, Kitagawa Y
    © 2019 Author(s). Introduction: The prevalence of surgical site infection (SSI) remains higher in gastrointestinal surgery than in other surgeries. Although several guidelines have indicated the efficacy of chlorhexidine and povidone-iodine in reducing the SSI rate, the optimal recommendation has still not been established. Therefore, it is necessary to determine the more effective antiseptic for surgical site preparation. Olanexidine (1.5% olanedine, Otsuka Pharmaceutical Factory, Tokushima, Japan), which is a new antiseptic in Japan, has antimicrobial activity against a wide range of bacteria, including Gram-positive and Gram-negative bacteria. Our study will contribute to determining a new antiseptic for use in gastrointestinal and other surgeries. Methods and analysis: We propose a multicentre, randomised controlled clinical trial for comparing two treatments, that is, 1.5% olanexidine or 10% povidone-iodine, for surgical skin preparation to prevent SSI in clean-contaminated gastrointestinal surgeries with surgical wounds. Patients aged ≥20 years at the time of consent will be included. The primary outcome measure is the 30-day postoperative SSI rate. For the primary analysis, which is aimed at comparing the treatment effects, the adjusted risk ratio and its 95% CI will be estimated using the Mantel-Haenszel method. Ethics and dissemination: The protocol was first approved by the Institutional Review Board of Keio University School of Medicine, followed by the institutional review board of each participating site. Participant recruitment began in June 2018. The final results will be published in international peer-reviewed medical journals.
    BMJ Open, May 2019, BMJ Open, 9(5) (5), e028269 - e028269
    Scientific journal

  • 高度リンパ節転移を有する食道扁平上皮癌における術前DCF療法と術前CF療法の予後の比較検討
    天田 塩, 川久保 博文, 眞柳 修平, 入野 誠之, 中村 理恵子, 和田 則仁, 北川 雄光
    (一社)日本外科学会, Apr. 2019, 日本外科学会定期学術集会抄録集, 119回, PS - 2, Japanese

  • Kato F, Wada N, Hayashida T, Fukuda K, Nakamura R, Takahashi T, Kawakubo H, Takeuchi H, Kitagawa Y
    Oncology Letters, Mar. 2019, Oncology Letters, 17(3) (3), 3097 - 3102, English
    Scientific journal

  • Hayashi M, Kawakubo H, Shoji Y, Mayanagi S, Nakamura R, Suda K, Wada N, Takeuchi H, Kitagawa Y
    © 2018, Société Internationale de Chirurgie. Background: Although esophagectomy is the only curative option for esophageal cancer, the associated invasiveness is high. Nasogastric (NG) tube use may prevent complications; however, its utility remains unclear, and the decompression period depends on the doctor. This study aimed to reveal the effect of conventional versus early NG tube removal on postoperative complications after esophagectomy. Methods: This single-center prospective randomized controlled clinical trial enrolled patients aged 20–80 years with histologically proven primary esophageal squamous cell carcinoma. Eighty patients admitted for transthoracic first-stage esophagectomy reconstructed with gastric conduit were randomly assigned (1:1) to the conventional and early NG tube removal groups. In the conventional NG tube removal group, the tube was removed on postoperative day (POD) 7; in the other, it was removed on POD 1. The occurrence rate of major complications, length of postoperative hospital stay, and NG tube reinsertion rate were compared between the groups. Results: The incidence of postoperative major complications such as pneumonia, anastomotic leakage, recurrent nerve palsy and gastrointestinal bleeding, and the NG tube reinsertion rate was not different between the groups. However, recurrent nerve palsy was more commonly observed in the conventional removal group; this difference was not significant. In terms of postoperative pneumonia, tumor location and field of lymph node dissection were significant risk factors. Conclusion: Although early NG tube removal did not reduce the rate of postoperative pneumonia, it could be performed safely. Hence, the NG tube can be removed earlier than conventional methods.
    World Journal of Surgery, Feb. 2019, World Journal of Surgery, 43(2) (2), 580 - 589, English, International magazine
    Scientific journal

  • Nakamura R, Omori T, Mayanagi S, Irino T, Wada N, Kawakubo H, Kameyama K, Kitagawa Y
    World Journal of Surgical Oncology, Feb. 2019, World Journal of Surgical Oncology, 17(1) (1), English
    Scientific journal

  • Takeuchi M, Kawakubo H, Mayanagi S, Irino T, Fukuda K, Nakamura R, Wada N, Takeuchi H, Kitagawa Y
    Annals of Surgical Oncology, 2019, Annals of Surgical Oncology, English
    Scientific journal

  • Matsunaga T, Ohnishi K, Wada N, Kitagawa Y
    IEEJ Transactions on Industry Applications, 2019, IEEJ Transactions on Industry Applications, 139(12) (12), 966 - 972, Japanese
    Scientific journal

  • Shiroshita H, Inomata M, Bandoh T, Uchida H, Akira S, Hashizume M, Yamaguchi S, Eguchi S, Wada N, Takiguchi S, Ieiri S, Endo S, Iwazaki M, Tamaki Y, Tabata M, Kanayama H, Mimata H, Hasegawa T, Onishi K, Yanaga K, Morikawa T, Terachi T, Matsumoto S, Yamashita Y, Kitano S, Watanabe M
    © 2019 Japan Society for Endoscopic Surgery, Asia Endosurgery Task Force and John Wiley & Sons Australia, Ltd. In Japan, the first endoscopic surgery, a laparoscopic cholecystectomy, was performed in 1990. Since then, the operative procedure has been standardized, and the safety and usefulness of endoscopic surgery have been evaluated. In accordance with the social acceptance of endoscopic surgery as a less-invasive surgery, the number of endoscopic procedures has been increasing in all surgical domains. The Japan Society for Endoscopic Surgery (JSES) has played an important role in the development of endoscopic surgery in Japan. For example, JSES established a technical skills certification system for surgeons to train instructors how to teach safe endoscopic surgery, and the organization performs a national survey every 2 years. In 2015, a total of 211 953 patients underwent endoscopic surgery in all surgical domains, including abdominal, thoracic, mammary and thyroid gland, cardiovascular, obstetrics and gynecology, urologic, orthopedic, and plastic surgery. The course of laparoscopic surgery's development and its current status are reported here based on the results of the most recent questionnaire survey conducted by JSES.
    Asian journal of endoscopic surgery, Jan. 2019, Asian journal of endoscopic surgery, 12(1) (1), 7 - 18, English, Domestic magazine
    Scientific journal

  • Yura M, Takeuchi H, Fukuda K, Nakamura R, Suda K, Wada N, Kawakubo H, Kitagawa Y
    © 2018 The Authors. Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterological Surgery Aim: The aim of the present study was to clarify esophagogastric junction (EGJ) carcinoma patients who are at high risk of upper and middle mediastinal lymph node (MLN) metastasis. Methods: This was a retrospective study and included 110 consecutive patients with EGJ carcinoma who underwent R0/R1 resection at Keio University Hospital between January 2000 and December 2013. Results: Of the 110 patients, 18 (16.3%) had MLN metastasis, and the number increased to 23 (20.9%) when recurrence cases were added (adenocarcinoma, N = 11; squamous cell carcinoma, N = 12). Patients whose tumor epicenter was located above the EGJ had a significantly higher incidence of MLN metastasis/recurrence (18/51 [35.3%]) than those whose tumor epicenter was located below the EGJ (5/59 [8.5%]). The MLN metastasis/recurrence rate was particularly high when the distance from the EGJ to the proximal edge of the primary tumor was >3 cm for the upper and middle mediastinum (18.8%). Patients in a selected group (≥T2 and tumor epicenter located above the EGJ or below the EGJ with ≥3 cm esophageal invasion) showed 17.9% and 15.4% upper and middle MLN metastasis/recurrence rates, respectively. Therapeutic value of MLN dissection was relatively high (#105 + 106: 8.9, #110: 12.2). Conclusions: Therapeutic value of MLN dissection to treat EGJ carcinomas was relatively high in patients with MLN metastasis. Our algorithm could select patients at high risk for MLN metastasis.
    Annals of Gastroenterological Surgery, Nov. 2018, Annals of Gastroenterological Surgery, 2(6) (6), 419 - 427, English, Domestic magazine
    Scientific journal

  • 食道癌手術患者における血小板値と予後の関連
    天田 塩, 川久保 博文, 中村 理恵子, 眞柳 修平, 須田 康一, 和田 則仁, 北川 雄光
    (一社)日本癌治療学会, Oct. 2018, 日本癌治療学会学術集会抄録集, 56回, O60 - 2, English

  • 天田 塩, 中村 理恵子, 眞柳 修平, 和田 則仁, 須田 康一, 川久保 博文, 北川 雄光
    (一社)日本消化器内視鏡学会-関東支部, Jun. 2018, Progress of Digestive Endoscopy, 93(Suppl.) (Suppl.), s110 - s110, Japanese

  • 3次元画像解析システムによる気管支動脈の解剖解析の可能性
    天田 塩, 川久保 博文, 眞柳 修平, 中村 理恵子, 和田 則仁, 須田 康一, 竹内 裕也, 北川 雄光
    (NPO)日本食道学会, Jun. 2018, 日本食道学会学術集会プログラム・抄録集, 72回, 68 - 68, Japanese

  • 胃癌手術患者の術前における予後予測因子の検討
    天田 塩, 川久保 博文, 眞柳 修平, 福田 和正, 中村 理恵子, 須田 康一, 和田 則仁, 北川 雄光
    (一社)日本外科学会, Apr. 2018, 日本外科学会定期学術集会抄録集, 118回, 1288 - 1288, Japanese

  • 胃癌手術患者における術後縫合不全予測因子の検討(ABCs is a predictive factor for anastomotic leakage of radical gastrectomy for gastric cancer)
    天田 塩, 川久保 博文, 眞柳 修平, 福田 和正, 須田 康一, 中村 理恵子, 和田 則仁, 北川 雄光
    (一社)日本胃癌学会, Mar. 2018, 日本胃癌学会総会記事, 90回, 381 - 381, English

  • 【婦人科がん(第2版)-最新の研究動向-】わが国のがん医療 総論 次世代がん医療の展望
    北川 雄光, 西原 広史, 和田 則仁, 林田 晢, 八木 洋, 浜本 康夫
    (株)日本臨床社, Mar. 2018, 日本臨床, 76(増刊2 婦人科がん) (増刊2 婦人科がん), 11 - 17, Japanese
    [Refereed]

  • Aoyama Junya, Kawakubo Hirofumi, Mayanagi Shuhei, Fukuda Kazumasa, Suda Koichi, Nakamura Rieko, Wada Norihito, Kitagawa Yuko
    Feb. 2018, JOURNAL OF CLINICAL ONCOLOGY, 36(4) (4)
    [Refereed]

  • ENDOSCOPIC FINDINGS OF LARYNGOPHARYNGEAL AND ESOPHAGEAL INVOLVEMENT IN AUTOIMMUNE BULLOUS DISEASE
    NAKAMURA Rieko, OMORI Tai, SUDA Koichi, WADA Norihito, KAWAKUBO Hirofumi, TAKEUCHI Hiroya, YAMAGAMI Jun, AMAGAI Masayuki, KITAGAWA Yuko
    <p>Background and Aim: Autoimmune bullous disease (ABD) is induced by autoantibodies against cell adhesion molecules, and blistering may occur on the mucous membranes of the eyes, nose, mouth, oral cavity, laryngopharynx, and esophagus. Endoscopic prevalence and features of ABD-associated esophageal lesions are not well known. We conducted the present study to assess the endoscopic prevalence of ABD-associated mucosal lesions. </p><p>Methods: Endoscopic prevalence of mucosal lesions, particularly laryngopharyngeal and esophageal lesions, was used as the primary endpoint to assess the significance of upper gastrointestinal endoscopy, and clinical and endoscopic features were secondary endpoints. </p><p>Results: Of 123 ABD patients, 50.4％ had apparent oral or laryngopharyngeal lesions and 30.8％ had laryngopharyngeal lesions. Esophageal lesions were detected through normal observation in 16.8％ of affected patients, whereas 40.6％ exhibited epidermolysis or blood blisters by mechanical inducement, regardless of esophageal mucosal lesion detection by normal observation. Additionally, 56.0％ exhibited the Nikolsky sign with mechanical inducement. Of the 123 patients, 29.2％ did not have exposed skin lesions. Of these patients, 77.7％ had oral cavity or laryngopharyngeal lesions, 36.1％ had esophageal lesions, and 58.3％ exhibited the Nikolsky sign on esophageal mucosa. </p><p>Conclusion: It is important to determine the endoscopic characteristics and findings of ABD. ABD can be suspected from endoscopic findings. </p>
    Japan Gastroenterological Endoscopy Society, 2018, GASTROENTEROLOGICAL ENDOSCOPY, 60(8) (8), 1515 - 1526, Japanese

  • 腹腔鏡下胃癌手術患者における術後合併症予測因子の検討
    天田 塩, 川久保 博文, 眞柳 修平, 中村 理恵子, 須田 康一, 和田 則仁, 北川 雄光
    (一社)日本内視鏡外科学会, Dec. 2017, 日本内視鏡外科学会雑誌, 22(7) (7), EP192 - 08, Japanese

  • 頸部食道癌化学放射線治療後10年に再発を認めた1例
    竹内 優志, 中村 理恵子, 真柳 修平, 福田 和正, 須田 康一, 和田 則仁, 川久保 博文, 竹内 裕也, 北川 雄光
    73歳男。62歳時に頸部食道癌と診断され、喉頭全摘を回避するため化学放射線療法を施行され、2コース施行後の効果判定はCRであった。初回治療から9年半後、嚥下時違和感および咽頭痛が出現し、上部消化管内視鏡検査で切歯17cm〜22cm迄に白苔を伴う隆起性病変を認めた。食道造影検査では下咽頭〜頸部食道右側壁に陰影欠損像を認め、その肛門側に25mm大の腫瘤像を認めた。生検病理診断では肉腫様変化を示す低分化な扁平上皮癌が疑われ、食道癌(Ce CRT-Type 5b cT2N0M0 cStage II)と術前診断し、咽頭喉頭頸部食道全摘・遊離空腸再建・永久気管孔造設を行なった。手術検体病理組織学的診断では部分的に角化を伴い、地図状・中小胞巣状に浸潤する癌であり、扁平上皮癌(pT3、INFb、pIM0、ly0、v0、pPM0、pDM0、pRM0、pN0、pStage II)と診断した。現在術後半年経過しているが、無再発生存中である。
    (一社)日本消化器内視鏡学会-関東支部, Dec. 2017, Progress of Digestive Endoscopy, 91(1) (1), 130,7 - 131,7, Japanese

  • Rieko Nakamura, Tai Omori, Koichi Suda, Norihito Wada, Hirofumi Kawakubo, Hiroya Takeuchi, Jun Yamagami, Masayuki Amagai, Yuko Kitagawa
    Nov. 2017, DIGESTIVE ENDOSCOPY, 29(7) (7), 765 - 772, English
    [Refereed]
    Scientific journal

  • 組換え型トロンボモジュリンの周術期投与によるT細胞動態制御が示唆する新規抗腫瘍治療の可能性
    天田 塩, 福田 和正, 熊谷 厚志, 須田 康一, 中村 理恵子, 和田 則仁, 川久保 博文, 北川 雄光
    (一社)日本消化器外科学会, Oct. 2017, 日本消化器外科学会雑誌, 50(Suppl.2) (Suppl.2), 542 - 542, Japanese

  • 胃癌手術患者における術後合併症予測因子の検討
    天田 塩, 川久保 博文, 眞柳 修平, 中村 理恵子, 須田 康一, 和田 則仁, 北川 雄光
    日本臨床外科学会, Oct. 2017, 日本臨床外科学会雑誌, 78(増刊) (増刊), 604 - 604, Japanese

  • 天田 塩, 川久保 博文, 眞柳 修平, 須田 康一, 中村 理恵子, 和田 則仁, 北川 雄光
    (一社)日本外科感染症学会, Oct. 2017, 日本外科感染症学会雑誌, 14(5) (5), 605 - 605, Japanese

  • 食道癌手術に即した気管支動脈の分類の検討
    天田 塩, 川久保 博文, 真柳 修平, 須田 康一, 中村 理恵子, 和田 則仁, 北川 雄光
    (一社)日本癌治療学会, Oct. 2017, 日本癌治療学会学術集会抄録集, 55回, IS4 - 3, English

  • 胃癌手術患者における術後合併症予測因子の検討
    天田 塩, 竹内 祐也, 福田 和正, 中村 理恵子, 須田 康一, 和田 則仁, 川久保 博文, 北川 雄光
    (一社)日本外科学会, Apr. 2017, 日本外科学会定期学術集会抄録集, 117回, SF - 3, Japanese

  • 【内視鏡所見から全身を診る】自己免疫疾患・膠原病・血管炎など 天疱瘡・類天疱瘡を疑う食道病変
    中村 理恵子, 大森 泰, 須田 康一, 和田 則仁, 川久保 博文, 竹内 裕也, 山上 淳, 天谷 雅行, 北川 雄光
    (株)東京医学社, Apr. 2017, 消化器内視鏡, 29(4) (4), 716 - 718, Japanese

  • 胃癌手術患者における術後合併症予測因子の検討(ABC score can be a predictive factor for postoperative complications of laparoscopic gastrectomy)
    天田 塩, 竹内 祐也, 福田 和正, 中村 理恵子, 須田 康一, 和田 則仁, 川久保 博文, 北川 雄光
    (一社)日本胃癌学会, Mar. 2017, 日本胃癌学会総会記事, 89回, 319 - 319, English

  • Takeuchi Hiroya, Goto Osamu, Shimada Ayako, Fukuda Kazumasa, Nakamura Rieko, Suda Koichi, Wada Norihito, Kawakubo Hirofumi, Yahagi Naohisa, Kitagawa Yuko
    Feb. 2017, JOURNAL OF CLINICAL ONCOLOGY, 35(4) (4)
    [Refereed]

  • 上部消化管内視鏡下手術におけるナビゲーションの取り組み 食道癌手術におけるCT angiographyおよび3次元画像解析システムを用いた気管支動脈の解剖解析
    天田 塩, 竹内 裕也, 和田 剛幸, 須田 康一, 中村 理恵子, 川久保 博文, 和田 則仁, 陣崎 雅弘, 北川 雄光
    (一社)日本内視鏡外科学会, Dec. 2016, 日本内視鏡外科学会雑誌, 21(7) (7), RS5 - 1, Japanese

  • 食道癌周術期サイトカイン値と予後に関する検討
    前田 祐助, 竹内 裕也, 松田 諭, 菊池 勇次, 福田 和正, 中村 理恵子, 高橋 常浩, 和田 則仁, 川久保 博文, 宮庄 拓, 北川 雄光
    (一社)日本消化器外科学会, Nov. 2016, 日本消化器外科学会雑誌, 49(Suppl.2) (Suppl.2), 244 - 244, Japanese

  • 食道癌手術におけるCT angiographyおよび3次元画像解析システムを用いた下甲状腺動脈の解剖解析
    天田 塩, 竹内 祐也, 和田 剛幸, 須田 康一, 中村 理恵子, 川久保 博文, 和田 則仁, 陣崎 雅弘, 北川 雄光
    日本臨床外科学会, Oct. 2016, 日本臨床外科学会雑誌, 77(増刊) (増刊), 661 - 661, Japanese

  • 胃 手術療法 腹腔鏡下胃癌手術患者における術後合併症予測因子の検討
    天田 塩, 竹内 祐也, 福田 和正, 中村 理恵子, 須田 康一, 和田 則仁, 川久保 博文, 北川 雄光
    (一社)日本癌治療学会, Oct. 2016, 日本癌治療学会学術集会抄録集, 54回, WS46 - 4, Japanese

  • GIST GISTに対する分子標的薬治療 食道胃接合部の粘膜下腫瘍に対する手術戦略
    鴇沢 一徳, 竹内 裕也, 川久保 博文, 後藤 修, 庄司 佳晃, 福田 和正, 中村 理恵子, 須田 康一, 和田 則仁, 矢作 直久, 北川 雄光
    (一社)日本癌治療学会, Oct. 2016, 日本癌治療学会学術集会抄録集, 54回, MS24 - 4, Japanese

  • 初診時血清CRPと術前血清Albによる食道癌手術患者の再発リスク評価の検討
    天田 塩, 竹内 祐也, 川久保 博文, 福田 和正, 中村 理恵子, 高橋 常浩, 和田 則仁, 北川 雄光
    (NPO)日本食道学会, Jul. 2016, 日本食道学会学術集会プログラム・抄録集, 70回, 185 - 185, Japanese

  • 食道癌手術患者における周術期静脈血栓症発症が予後に及ぼす影響の検討
    天田 塩, 竹内 裕也, 加藤 文彦, 川久保 博文, 福田 和正, 中村 理恵子, 高橋 常浩, 和田 則仁, 北川 雄光
    (一社)日本外科学会, Apr. 2016, 日本外科学会定期学術集会抄録集, 116回, PS - 2, Japanese

  • 十二指腸内視鏡的粘膜下層剥離術後の偶発的穿孔の治療戦略に関する検討
    天田 塩, 竹内 裕也, 中村 理恵子, 高橋 常浩, 和田 則仁, 日比 泰造, 八木 洋, 板野 理, 後藤 修, 矢作 直久, 北川 雄光
    (一社)日本腹部救急医学会, Feb. 2016, 日本腹部救急医学会雑誌, 36(2) (2), 395 - 395, Japanese

  • 竹内 裕也, 中原 理紀, 島田 理子, 後藤 修, 福田 和正, 中村 理恵子, 高橋 常浩, 和田 則仁, 川久保 博文, 村上 康二, 矢作 直久, 北川 雄光
    日本リンパ学会, Dec. 2015, リンパ学, 38(2) (2), 74 - 77, Japanese

  • Tanaka Motomu, Takeuchi Hiroya, Osaki Yoshiki, Hiraiwa Kunihiko, Nakamura Rieko, Oyama Takashi, Takahashi Tsunehiro, Wada Norihito, Kawakubo Hirofumi, Saikawa Yoshiro, Omori Tai, Kitagawa Yuko
    Oct. 2015, ESOPHAGUS, 12(4) (4), 352 - 359
    [Refereed]

  • Phase I Study of S-1 plus Fractional Cisplatin as Adjuvant Chemotherapy for Advanced Gastric Cancer in an Outpatient Setting (KOGC-03)
    Takahashi, Tsunehiro, Saikawa, Yoshiro, Fukuda, Kazumasa, Nakamura, Rieko, Wada, Norihito, Kawakubo, Hirofumi, Takeuchi, Hiroya, Takaishi, Hiromasa, Icitagawa, Yuko
    Jan. 2015, ANTICANCER RESEARCH, 35(1) (1), 467 - 471, English
    Scientific journal

  • AMAGAI MASAYUKI
    Jun. 2014, Progress of Digestive Endoscopy, 84(1) (1), 70 - 71, Japanese
    [Refereed]
    Scientific journal

  • The neutrophil elastase inhibitor sivelestat suppresses accelerated gastrointestinal tumor growth via peritonitis after cecal ligation and puncture.
    Koshi Kumagai, Yoshiro Saikawa, Hiroya Takeuchi, Koichi Suda, Kazumasa Fukuda, Rieko Nakamura, Tsunehiro Takahashi, Hirofumi Kawakubo, Norihito Wada, Taku Miyasho, Yuko Kitagawa
    BACKGROUND: We examined whether tumor growth is enhanced by cecal ligation and puncture (CLP) and suppressed by a neutrophil elastase inhibitor, sivelestat. MATERIALS AND METHODS: C57BL/6 mice were divided in CLP/sivelestat, CLP alone, and control (simple laparotomy) groups. Murine CT26 colon carcinoma cells were injected subcutaneously into the back of each mouse and tumor growth and serum cytokine levels were assessed. RESULTS: Mice subjected to CLP alone exhibited enhanced tumor growth compared to controls with subcutaneously injected CT26 cells (0.64±0.24 g vs. 0.021±0.027 g, p<0.001), while treatment with CLP/sivelestat produced smaller tumors than CLP alone (0.28±0.23 g vs. 0.64±0.24 g, p=0.006). Cytokine assays showed suppressed production of interleukin (IL)-6 and IL-10 in the CLP/sivelestat group, and increased IL-6 and IL-10 in the CLP-alone group. CONCLUSION: Intra-abdominal inflammation induced by CLP enhances the growth of subcutaneously implanted tumors, while perioperative administration of sivelestat suppresses tumor growth by affecting systemic inflammation.
    Sep. 2013, Anticancer research, 33(9) (9), 3653 - 9, English, International magazine
    Scientific journal

  • AMAGAI MASAYUKI
    Jun. 2013, Progress of Digestive Endoscopy, 82(1) (1), 94 - 95, Japanese

  • Phase I study of neoadjuvant chemoradiotherapy as an outpatient setting for patients with resectable advanced gastric cancer
    Takahashi, Tsunehiro, Saikawa, Yoshiro, Wada, Norihito, Kawakubo, Hirofumi, Takeuchi, Hiroya, Takaishi, Hiromasa, Kitagawa, Yuko
    Feb. 2013, JOURNAL OF CLINICAL ONCOLOGY, 31(4) (4), 3759 - 3762, English
    Scientific journal

  • Chemoradiotherapy for advanced gastric cancer
    Takahashi Tsunehiro, Saikawa Yoshiro, Fukuda Kazumasa, Wada Norihito, Kawakubo Hirofumi, Takeuchi Hiroya, Fukada Junichi, Kawaguchi Osamu, Takaishi Hiromasa, Shigematsu Naoyuki, Kitagawa Yuko
    <p>In the US and Europe, chemoradiotherapy has become a standard treatment not only for head and neck cancer, esophageal cancer, pancreatic cancer, and rectal cancer, but also for gastric cancer. In particular, chemoradiotherapy has been established as an adjuvant therapy. In Japan, it has not been established as a standard treatment. Its indications are limited, and it is often performed as palliative care. Disadvantages of radiation therapy for gastric cancer include the difficulty of establishing the area to irradiate due to peristaltic movement, risk of perforation and ulceration from high-dose radiation, and ineffectiveness against adenocarcinoma with low radiosensitivity. In recent years, technological advancement of radiation therapy has enabled pinpoint accuracy in the treatment of primary gastric lesions and regional lymph nodes. There has been much anticipation that chemoradiotherapy will become a part of multidisciplinary treatment for advanced cancer. This report describes the current state of chemoradiotherapy for gastric cancer in Japan and overseas, and outlines our approach to locally advanced gastric cancer.</p>
    Dec. 2012, Japanese Journal of Cancer and Chemotherapy, 39(13) (13), 2464 - 2468, English

  • Takahashi Tsunehiro
    Dec. 2011, Progress of Digestive Endoscopy, 79(2) (2), 72-73, Japanese
    [Refereed]
    Scientific journal

  • Phase I study of neoadjuvant chemoradiotherapy consisting of S-1 and cisplatin for patients with resectable advanced gastric cancer (KOGC-01)
    Takahashi Tsunehiro, Saikawa Yoshiro, Takaishi Hiromasa, Takeuchi Hiroya, Wada Norihito, Oyama Takashi, Fukuda Kazumasa, Fukada Junichi, Kawaguchi Osamu, Shigematsu Naoyuki, Kitagawa Yuko
    <p>Background: The prognosis for advanced gastric cancer is poor, with surgery as the only treatment for resectable advanced gastric cancer. Therefore, treatment options that might improve the prognosis are needed. To that end, neoadjuvant chemoradiotherapy with S-1 and cisplatin (CDDP) was investigated. Patients and Methods: The chemotherapy schedule included one cycle repeated after 6 weeks. S-1 was administered orally every day on days 1-21 and CDDP was infused on days 1, 8 and 15. Radiation therapy was started concurrently with chemotherapy and repeated daily on days 1-5, 8-12, 15-19, and 22-26. Results: A total of 10 patients were recruited. The first four patients were entered into level 1 (CDDP, 20 mg/m<sup>2</sup>). The next six patients were entered into level 0 (15 mg/m<sup>2</sup>), because of dose-limiting toxicity (delaying the second course of chemotherapy in two patients) that had been observed at level 1. The maximum tolerated dose (MTD) of CDDP was 20 mg/m<sup>2</sup>. Seven patients underwent surgery and all had an R0 (no residual tumor) resection without surgical complications. Conclusion: Neoadjuvant chemoradiotherapy with S-1 and CDDP may cause surgery to be de
    Sep. 2011, Anticancer Research, 31(9) (9), 3079 - 3083, English

  • 侵襲性血管粘液腫との鑑別が困難であった鼠径部脂肪腫の一例
    矢作 芙美子, 和田 則仁, 尾曲 健司, 茂田 浩平, 星野 剛, 高橋 剛志, 平野 佑樹, 代永 和秀, 平尾 薫丸, 向井 万起男, 北川 雄光
    日本臨床外科学会, Jun. 2011, 日本臨床外科学会雑誌, 72(6) (6), 1636 - 1636, Japanese

  • 冠城 拓示, 竹内 裕也, 大山 隆史, 中村 理恵子, 高橋 常浩, 和田 則仁, 才川 義朗, 中村 理紀, 村上 康二, 深田 淳一, 茂松 直之, 北川 雄光
    (一社)日本外科学会, May 2011, 日本外科学会雑誌, 112(臨増1-2) (臨増1-2), 838 - 838, Japanese

  • 当院における食道・胃接合部腺癌の検討
    尾曲 健司, 竹内 裕也, 津和野 伸一, 迫 裕之, 西 知彦, 平野 祐樹, 中村 理恵子, 大山 隆史, 高橋 常浩, 和田 則仁, 才川 義朗, 北川 雄光
    (一社)日本胃癌学会, Mar. 2011, 日本胃癌学会総会記事, 83回, 240 - 240, Japanese

  • 食道がん手術における補助療法の導入とその効果 胸部食道癌に対する集学的治療の意義と問題点
    竹内 裕也, 大山 隆史, 西 知彦, 新原 正大, 迫 裕之, 平野 祐樹, 尾曲 健司, 高橋 常浩, 和田 則仁, 中村 理恵子, 才川 義朗, 茂松 直之, 北川 雄光
    日本臨床外科学会, Oct. 2010, 日本臨床外科学会雑誌, 71(増刊) (増刊), 331 - 331, Japanese

  • 食道アカラシアに対する単孔式腹腔鏡下Heller and Dor法の手術手技
    竹内 裕也, 大山 隆史, 尾曲 健司, 平野 祐樹, 高橋 常浩, 中村 理恵子, 和田 則仁, 才川 義朗, 北川 雄光
    (一社)日本内視鏡外科学会, Oct. 2010, 日本内視鏡外科学会雑誌, 15(7) (7), 333 - 333, Japanese

  • 星野 剛, 和田 則仁, 才川 義朗, 高橋 常浩, 茂田 浩平, 矢作 芙美子, 高橋 剛志, 代永 和秀, 平野 祐樹, 中村 理恵子, 大山 隆史, 竹内 裕也, 北川 雄光
    (株)勁草書房コミュニケーション事業部, Jul. 2010, 胃病態機能研究会誌, 42, 16 - 16, Japanese

  • 竹内 裕也, 才川 義朗, 大山 隆史, 平野 祐樹, 和田 則仁, 高橋 常浩, 中村 理恵子, 北川 雄光
    (株)南江堂, Mar. 2010, 外科, 72(3) (3), 229 - 233, Japanese

  • Case 1. A recurrence-free case of esophageal cancer given definitive chemoradiation therapy because of good response to neoadjuvant therapy
    Nishi Tomohiko, Takeuchi Hiroya, Saikawa Yoshiro, Oyama Takashi, Wada Norihito, Suganuma Kazuhiro, Hiraiwa Kunihiko, Kumagai Koshi, Fukada Junichi, Shigematsu Naoyuki, Mukai Makio, Kitagawa Yuko
    Mar. 2010, ESOPHAGUS, 7(1) (1), 76
    [Refereed]

  • Takeuchi Hiroya, Saikawa Yoshiro, Oyama Takashi, Ozawa Soji, Suda Koichi, Wada Norihito, Takahashi Tsunehiro, Nakamura Rieko, Shigematsu Naoyuki, Ando Nobutoshi, Kitajima Masaki, Kitagawa Yuko
    <p>Background: Salvage esophagectomy is potentially the only treatment available that can offer a chance of long-term survival when definitive chemoradiotherapy (CRT) fails to achieve local control for patients with esophageal squamous cell carcinoma (ESCC). However, salvage esophagectomy is a highly invasive procedure with various postoperative complications compared to planned esophagectomy after neoadjuvant chemoradiotherapy (CRT). We hypothesize that severe postoperative complications may affect not only surgical mortality but also tumor recurrence and long-term survival for patients with salvage esophagectomy after definitive CRT. Methods: For the present study we reviewed the surgical procedures, postoperative complications, and the prognosis of 65 consecutive patients with thoracic ESCC who underwent the esophagectomy after neoadjuvant (neoadjuvant group: n = 40) or definitive (salvage group: n = 25) CRT. Results: Most patients underwent right-transthoracic extended esophagectomy and reconstruction using gastric conduit by way of subcutaneous route with left cervical anastomosis. The incidence of postoperative pneumonia was found to be higher in the salvage group than in the
    Feb. 2010, World Journal of Surgery, 34(2) (2), 277 - 284, English

  • 井田 陽介, 今枝 博之, 細江 直樹, 別所 理恵子, 中村 理恵子, 平野 佑樹, 斉藤 義正, 鈴木 秀和, 和田 則仁, 竹内 裕也, 才川 義朗, 岩男 泰, 緒方 晴彦, 北川 雄光, 日比 紀文
    (一社)日本消化器内視鏡学会-関東支部, Dec. 2009, Progress of Digestive Endoscopy, 76(1) (1), 69 - 69, Japanese

  • 80歳以上の胃癌手術症例の検討
    平野 佑樹, 竹内 裕也, 須田 康一, 吉川 貴久, 才川 義郎, 和田 則仁, 菅沼 和弘, 大山 隆史, 熊谷 厚志, 北川 雄光
    (一社)日本消化器外科学会, Jul. 2009, 日本消化器外科学会雑誌, 42(7) (7), 1199 - 1199, Japanese

  • 胃癌癌性消化管閉塞へのOctreotide Acetate投与下S-1を含む化学放射線療法の試み
    五十嵐 高広, 才川 義朗, 熊谷 厚志, 和田 則仁, 竹内 裕也, 久保田 哲朗, 北川 雄光
    (一社)日本胃癌学会, Mar. 2009, 日本胃癌学会総会記事, 81回, 231 - 231, Japanese

  • 須田康一, 竹内裕也, 宮庄拓, 岡本実, 和田則仁, 才川義朗, 福永興壱, 山田晋吾, 横田博, 丸山征郎, 石坂彰敏, 北川雄光
    医学図書出版(株), 2009, エンドトキシン研究, 11, 7 - 9, Japanese

  • SUZUKI HIDEKAZU
    2009, 日本腹部救急医学会雑誌, 29(7) (7), 951-956, Japanese
    Scientific journal

  • Longxue Jin, Masashi Yoshida, Tetsuya Nakamura, Hideki Ishikawa, Go Wakabayashi, Minoru Tanabe, Shigeyuki Kawachi, Masahiro Shinoda, Yoshiro Saikawa, Norihito Wada, Kaori Kameyama, Koichiro Kumai, Tetsuro Kubota, Katsuko Sano, Keisuke Nagao, Masayuki Amagai, Yuko Kitagawa, Masaki Kitajima
    Nov. 2008, DIGESTIVE DISEASES AND SCIENCES, 53(11) (11), 2878 - 2885, English
    Scientific journal

  • Tetsuya Nakamura, Masashi Yoshida, Yuko Kitagawa, Longxue Jin, Hideki Ishikawa, Kaori Kameyama, Go Wakabayashi, Minoru Tanabe, Shigeyuki Kawachi, Masahiro Shinoda, Yoshiro Saikawa, Norihito Wada, Tetsuro Kubota, Koichiro Kumai, Katsuko Sano, Masaki Kitajima
    Sep. 2008, DIGESTIVE DISEASES AND SCIENCES, 53(9) (9), 2422 - 2428, English
    Scientific journal

  • 熊谷 厚志, 竹内 裕也, 才川 義朗, 須田 康一, 菅沼 和弘, 和田 則仁, 久保田 哲朗, 北川 雄光
    (一社)日本消化器内視鏡学会-関東支部, Jun. 2008, Progress of Digestive Endoscopy, 73(1) (1), 81 - 81, Japanese

  • 入野 誠之, 竹内 裕也, 才川 義朗, 和田 則仁, 須田 康一, 平岩 訓彦, 熊谷 厚志, 津和野 伸一, 五十嵐 高広, 伊藤 亮, 吉川 貴久, 北川 雄光
    (一社)日本消化器内視鏡学会-関東支部, Jun. 2008, Progress of Digestive Endoscopy, 73(1) (1), 81 - 81, Japanese

  • 伊藤 亮, 才川 義朗, 五十嵐 高広, 津和野 伸一, 熊谷 厚志, 須田 康一, 菅沼 和弘, 和田 則仁, 竹内 裕也, 久保田 哲朗, 北川 雄光
    (一社)日本消化器内視鏡学会-関東支部, Jun. 2008, Progress of Digestive Endoscopy, 73(1) (1), 90 - 90, Japanese

  • 【食道疾患の臨床 update】食道の運動異常 アカラシアの治療
    須田 康一, 竹内 裕也, 吉川 貴久, 和田 則仁, 才川 義朗, 北川 雄光
    (株)日本メディカルセンター, May 2008, 臨床消化器内科, 23(7) (7), 854 - 858, Japanese

  • 【術前・術中のリンパ節転移診断の方法とその有用性】 胃癌における術前・術中のリンパ節転移診断の方法とその有用性
    竹内 裕也, 才川 義朗, 和田 則仁, 須田 康一, 北川 雄光
    (株)医学書院, Mar. 2008, 臨床外科, 63(3) (3), 347 - 352, Japanese

  • 侵襲とHMGB1
    須田 康一, 竹内 裕也, 菅沼 和弘, 和田 則仁, 才川 義朗, 北川 雄光
    日本外科系連合学会, Feb. 2008, 日本外科系連合学会誌, 33(1) (1), 95 - 96, Japanese

  • 【EMR,ESDの適応と手技 内科医との連携のために】 食道癌 食道表在癌に対する治療法の変遷
    竹内 裕也, 須田 康一, 才川 義朗, 和田 則仁, 北川 雄光
    (株)へるす出版, Jan. 2008, 消化器外科, 31(1) (1), 17 - 21, Japanese

  • The effect of Candida albicans infection on duodenal ulcer healing in rats
    Longxue Jin, Masashi Yoshida, Tetsuya Nakamura, Hideki Ishikawa, Go Wakabayashi, Motohide Simatsu, Minoru Tanabe, Shigeyuki Kawachi, Koichiro Kumai, Tetsuro Kubota, Yoshiro Saikawa, Norihito Wada, Kaori Kameyama, Masaki Kitajima
    Jan. 2008, WOUND REPAIR AND REGENERATION, 16(1) (1), A2 - A2, English
    Scientific journal

  • Norihito Wada
    Jan. 2008, LANGENBECKS ARCHIVES OF SURGERY, 393(1) (1), 115 - 115, English
    Scientific journal

  • 胃癌に対する機能温存、機能再建手術の評価 腹腔鏡下胃局所切除術の予後と術後機能評価
    五十嵐 高広, 和田 則仁, 才川 義朗, 伊藤 亮, 津和野 伸一, 熊谷 厚志, 清田 毅, 大橋 真記, 須田 康一, 竹内 裕也, 北川 雄光
    日本臨床外科学会, Nov. 2007, 日本臨床外科学会雑誌, 68(増刊) (増刊), 317 - 317, Japanese

  • 熊谷 厚志, 熊井 浩一郎, 中塚 誠之, 伊藤 亮, 五十嵐 高広, 津和野 伸一, 清田 毅, 大橋 真記, 和田 則仁, 才川 義朗, 久保田 哲朗, 北川 雄光
    (一社)日本消化器内視鏡学会-関東支部, Nov. 2007, Progress of Digestive Endoscopy, 71(2) (2), 68,4 - 69,4, Japanese

  • 和田 則仁, 才川 義朗, 吉田 昌, 大橋 真記, 清田 毅, 熊谷 厚志, 久保田 哲朗, 熊井 浩一郎, 北島 政樹
    (一社)日本消化器外科学会, Oct. 2007, 日本消化器外科学会雑誌, 40(10) (10), 1759 - 1759, Japanese

  • 胃粘膜下腫瘍に対する腹腔鏡下胃局所切除術の工夫
    五十嵐 高広, 和田 則仁, 伊藤 亮, 津和野 伸一, 熊谷 厚志, 清田 毅, 大橋 真記, 才川 義朗, 久保田 哲朗, 熊井 浩一郎, 北川 雄光
    日本臨床外科学会, Oct. 2007, 日本臨床外科学会雑誌, 68(10) (10), 2676 - 2676, Japanese

  • 【スキルス胃癌治療の最前線】Type4胃癌に対する手術治療の困難性と集学的治療の有用性
    熊谷 厚志, 才川 義朗, 中村 理恵子, 和田 則仁, 久保田 哲朗, 熊井 浩一郎, 北川 雄光
    (有)科学評論社, Aug. 2007, 消化器科, 45(2) (2), 154 - 160, Japanese

  • Rieko Nakamura, Yoshiro Saikawa, Norihito Wada, Masashi Yoshida, Tetsuro Kubota, Koichiro Kumai, Masaki Kitajima
    Aug. 2007, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 12(4) (4), 291 - 294, English
    Scientific journal

  • 【転移性肝癌の治療戦略】 胃癌肝転移の治療戦略
    和田 則仁, 大谷 吉秀, 熊井 浩一郎, 北島 政樹, 竹内 裕也, 才川 義朗, 久保田 哲朗, 吉田 昌, 須田 康一, 北川 雄光
    (有)科学評論社, Jul. 2007, 消化器科, 45(1) (1), 84 - 91, Japanese

  • 才川 義朗, 熊谷 厚志, 和田 則仁, 吉田 昌, 北川 雄光, 北島 政樹
    金原出版(株), Mar. 2007, 手術, 61(3) (3), 289 - 295, Japanese

  • Matrix metalloproteinase inhibitor, Marimastat, decreases peritoneal spread of gastric carcinoma in nude mice
    Kimata Masaru, Otani Yoshihide, Kubota Tetsuro, Igarashi Naoki, Yokoyama Takeyoshi, Wada Norihito, Yoshimizu Nobunari, Kameyama Kaori, Okada Yasunori, Kumai Koichiro, Kitajima Masaki
    Oct. 2002, Japanese journal of cancer research, 93, 834-841, English
    Scientific journal

  • The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice
    Minagawa Akiko, Otani Yoshihide, Kubota Teturo, Wada Norihito, Furukawa Toshiharu, Kumai Koichirou, Kameyama, Kaori, Okada Yasunori, Fujii Masato, Yano Masamichi, Sato Takashi, Ito Akira, Kitajima Masaki
    Dec. 2001, Japanese Journal of Cancer Research, 92(12) (12), 1322-1328, English
    Scientific journal

  • 残胃の異時性多発癌・多発腺腫の意義
    Wada Norihito, Kumai Kouichirou, Ootani Yoshihide, Sugino Yoshinori, Iwao Yasushi, Aiura Kouichi, Ekawa Tomohisa, Tokuyama Jou, Kurihara Naoto, Kubota Tetsurou, Kitajima Masaki
    Nov. 1999, 消化器内視鏡, 11(11) (11), 1525-1530, Japanese
    Scientific journal

  • Otani Yoshihide, Kubota Tetsuro, Sakurai Yoshihiko, Igarashi Naoki, Yokoyama Takeyoshi, Kimata Masaru, Wada Norihito, Kameyama Kaori, Kumai Koichiro, Okada Yasunori, Kitajima Masaki
    1999, Annals of the New York Academy of Sciences, 878, 541-543, English
    Scientific journal

■ MISC
  • Matsuda S, Takeuchi H, Kawakubo H, Takemura R, Maeda Y, Hirata Y, Kaburagi T, Egawa T, Nishi T, Ogura M, Miyasho T, Okamura A, Mayanagi S, Fukuda K, Nakamura R, Irino T, Wada N, Kitagawa Y
    Annals of Surgical Oncology, Dec. 2020, Annals of Surgical Oncology, 27(S3) (S3), 886 - 887

  • 食道癌術後患者の早期経口摂取回復を予測しうる因子の検討
    天田塩, 川久保博文, 須田康一, 中村理恵子, 和田則仁, 竹内裕也, 安藤牧, 村岡香織, 石川愛子, 北川雄光
    2017, 日本食道学会学術集会抄録集(CD-ROM), 71st

  • 内視鏡治療後早期胃癌症例に対するセンチネルリンパ節生検の有用性の検討
    真柳修平, 竹内裕也, 島田理子, 神谷諭, 新原正大, 中村理恵子, 須田康一, 和田則仁, 川久保博文, 才川義朗, 北川雄光
    2016, SNNS研究会学術集会プログラム抄録集, 18th

  • 急激に増大しリンパ節転移を呈した未分化型早期胃癌の一例
    由良昌大, 中村理恵子, 高橋常浩, 和田則仁, 川久保博文, 竹内裕也, 才川義朗, 辻川華子, 尾原健太郎, 佐々木文, 亀山香織, 北川雄光
    (一社)日本消化器内視鏡学会-関東支部, 2015, Progress of Digestive Endoscopy, 87(Supplement) (Supplement), s129 - s129, Japanese

  • 胃癌のセンチネルリンパ節における11番リンパ節の検討
    島田理子, 竹内裕也, 神谷諭, 福田和正, 中村理恵子, 高橋常浩, 和田則仁, 川久保博文, 才川義郎, 大森泰, 北川雄光
    2014, 日本臨床外科学会雑誌, 75

  • 積極的な支持療法により治療継続が可能となった,食道肺瘻合併Stage4食道癌の1例
    尾野大気, 竹内裕也, 神谷諭, 中村理恵子, 高橋常浩, 和田則仁, 川久保博文, 才川義朗, 大森泰, 北川雄光
    2013, 日本食道学会学術集会プログラム・抄録集, 67th

  • 早期胃癌に対するセンチネルリンパ節マッピングによる胃リンパ流の検討
    神谷諭, 竹内裕也, 中村理恵子, 高橋常浩, 和田則仁, 川久保博文, 才川義朗, 北川雄光
    2013, SNNS研究会学術集会プログラム抄録集, 15th

  • U領域早期胃癌における切除・再建術式の検討
    竹内裕也, 神谷諭, 中村理恵子, 高橋常浩, 和田則仁, 川久保博文, 才川義朗, 大森泰, 北川雄光
    2013, 日本胃癌学会総会記事, 85th

  • 胃癌におけるSentinel Node Navigation Surgeryの現状と展望
    神谷諭, 竹内裕也, 新原正大, 真柳修平, 中村理恵子, 高橋常浩, 和田則仁, 川久保博文, 才川義朗, 北川雄光
    2013, 日本消化器外科学会雑誌(Web), 46(Supplement1) (Supplement1)

  • 教室における早期胃癌センチネルリンパ節生検の成績と縮小手術の適応
    神谷諭, 竹内裕也, 新原正大, 真柳修平, 中村理恵子, 高橋常浩, 和田則仁, 川久保博文, 才川義朗, 中原理紀, 向井万起男, 大森泰, 北川雄光
    2012, 日本臨床外科学会雑誌, 73

  • 噴門側胃切除術における腹腔鏡下食道残胃吻合の評価
    竹内裕也, 神谷諭, 中村理恵子, 高橋常浩, 和田則仁, 川久保博文, 才川義朗, 大森泰, 北川雄光
    2012, 胃外科・術後障害研究会プログラム・抄録集, 42nd

  • Individualized Function-preserving Gastrectomy in Patients with Early Gastric Cancer
    竹内裕也, 神谷諭, 中村理恵子, 高橋常浩, 和田則仁, 川久保博文, 才川義朗, 大森泰, 北川雄光
    2012, 癌の臨床, 57(5) (5)

  • 【外科領域のステント治療の現状と展望】 上部消化管のステント治療の現状と展望
    和田 則仁, 中村 理恵子, 高橋 常浩, 大山 隆史, 竹内 裕也, 福田 和正, 才川 義朗, 北川 雄光
    (株)永井書店, Jun. 2011, 外科治療, 104(6) (6), 875 - 880, Japanese

  • 【StageIV胃癌治療への挑戦】 StageIV胃癌に対する化学放射線療法後の胃切除の意義
    高橋 常浩, 才川 義朗, 大山 隆史, 和田 則仁, 竹内 裕也, 深田 淳一, 川口 修, 高石 官均, 茂松 直之, 北川 雄光
    (株)へるす出版, May 2011, 消化器外科, 34(5) (5), 587 - 593, Japanese

  • 竹内 裕也, 大山 隆史, 才川 義朗, 和田 剛幸, 高橋 常浩, 和田 則仁, 中村 理恵子, 中原 理紀, 陣崎 雅弘, 栗林 幸夫, 北川 雄光
    (NPO)日本気管食道科学会, Apr. 2011, 日本気管食道科学会会報, 62(2) (2), 122 - 124, Japanese

  • 【転移性肝癌 多様化する治療】 胃癌肝転移の治療
    和田 則仁, 福田 和正, 中村 理恵子, 高橋 常浩, 大山 隆史, 竹内 裕也, 才川 義朗, 北川 雄光
    (株)日本メディカルセンター, Mar. 2011, 臨床消化器内科, 26(4) (4), 435 - 441, Japanese

  • 【GISTの診断と治療 最近の動向】 総論 わが国のGIST診療ガイドラインの現状、問題点と改訂点
    和田 則仁, 福田 和正, 高橋 常浩, 中村 理恵子, 大山 隆史, 竹内 裕也, 才川 義朗, 北川 雄光
    (株)へるす出版, Feb. 2011, 消化器外科, 34(2) (2), 143 - 150, Japanese

  • 高齢者消化器癌手術患者における術前RCRIの有用性に関する検討
    平野 佑樹, 竹内 裕也, 大山 隆史, 高橋 常浩, 和田 則仁, 才川 義朗, 中村 理恵子, 西 知彦, 迫 裕之, 尾曲 健司, 神野 浩光, 長谷川 博俊, 田辺 稔, 上田 政和, 北川 雄光
    (一社)日本癌治療学会, Sep. 2010, 日本癌治療学会誌, 45(2) (2), 689 - 689, Japanese

  • 継続する内視鏡治療にて長期生存している食道悪性黒色腫の1例
    尾曲 健司, 竹内 裕也, 大森 泰, 才川 義朗, 大山 隆史, 和田 則仁, 高橋 常浩, 中村 理恵子, 迫 裕之, 新原 正大, 西 知彦, 平野 佑樹, 林 雄一郎, 向井 萬起男, 北川 雄光
    (一社)日本消化器内視鏡学会, Sep. 2010, Gastroenterological Endoscopy, 52(Suppl.2) (Suppl.2), 2396 - 2396, Japanese

  • 横隔膜上食道憩室に対する鏡視下手術 術中内視鏡検査と腹腔鏡下経食道裂孔的アプローチ
    平野 佑樹, 竹内 裕也, 才川 義朗, 大山 隆史, 和田 則仁, 高橋 常浩, 中村 理恵子, 吉川 貴久, 入野 誠之, 北川 雄光
    (一社)日本消化器外科学会, Jul. 2010, 日本消化器外科学会総会, 65回, 57 - 57, Japanese

  • 【マスターしておきたい縫合・吻合法の実際 より安全・確実に行うために】 縫合・吻合法の実際 胸・腹腔鏡手術における縫合・吻合の実際 胸腔鏡下食道切除術における胸腔内食道胃管吻合
    竹内 裕也, 大山 隆史, 才川 義朗, 和田 則仁, 高橋 常浩, 中村 理恵子, 北川 雄光
    (株)永井書店, Apr. 2010, 外科治療, 102(増刊) (増刊), 644 - 647, Japanese

  • 腫瘍径が4cmを超える胃癌に対するセンチネルリンパ節生検症例の検討
    新原 正大, 竹内 裕也, 才川 義朗, 大山 隆史, 尾曲 健司, 迫 裕之, 西 知彦, 平野 佑樹, 和田 則仁, 高橋 常浩, 中村 理恵子, 北川 雄光
    (一社)日本胃癌学会, Mar. 2010, 日本胃癌学会総会記事, 82回, 336 - 336, Japanese

  • 術中センチネルリンパ節生検を併施した幽門保存胃切除術の成績
    神谷諭, 竹内裕也, 新原正大, 冠城拓示, 田中求, 和田剛幸, 尾曲健司, 迫裕之, 西知彦, 平野佑樹, 中村理恵子, 高橋常浩, 和田則仁, 才川義朗, 北川雄光
    2010, 日本臨床外科学会雑誌, 71

  • 胃腫瘍性病変の診療向上への基礎と臨床からのアプローチ 噴門側胃切除術におけるセンチネルリンパ節を指標とした転移診断
    神谷諭, 竹内裕也, 新原正大, 冠城拓示, 田中求, 和田剛幸, 尾曲健司, 西知彦, 迫裕之, 平野佑樹, 中村理恵子, 大山隆史, 高橋常浩, 和田則仁, 才川義朗, 北川雄光
    2010, 胃病態機能研究会誌, (42) (42)

  • 【今日の胃癌治療を知る】 胃癌機能温存・縮小手術とSentinel Node Navigation Surgery
    竹内 裕也, 才川 義朗, 和田 則仁, 高橋 常浩, 中村 理恵子, 大山 隆史, 北川 雄光
    (株)永井書店, Jan. 2010, 外科治療, 102(1) (1), 29 - 35, Japanese

  • センチネルリンパ節概念に基づくテーラーメードがん治療 センチネルリンパ節理論に基づく食道癌、胃癌に対するテーラーメードがん治療の現状と展望
    竹内 裕也, 才川 義朗, 和田 則仁, 大山 隆史, 高橋 常浩, 中村 理恵子, 北川 雄光
    日本リンパ学会, Dec. 2009, リンパ学, 32(2) (2), 81 - 86, Japanese

  • 消化器の創傷治癒研究の進歩 十二指腸潰瘍穿孔治癒における真菌の影響
    中村 哲也, 吉田 昌, 金 龍学, 和田 則仁, 才川 義朗, 石川 秀樹, 斎藤 淳一, 若林 剛, 北川 雄光, 北島 政樹
    (一社)日本創傷治癒学会, Dec. 2009, 日本創傷治癒学会プログラム・抄録集, 39回, 51 - 51, Japanese

  • 乳癌縦隔リンパ節再発による食道肺瘻、気管支狭窄の一例
    尾曲 健司, 竹内 裕也, 神野 浩光, 大山 隆史, 迫 裕之, 西 知彦, 新原 正大, 平野 祐樹, 中村 理恵子, 高橋 常浩, 和田 則仁, 才川 義朗, 北川 雄光
    日本臨床外科学会, Oct. 2009, 日本臨床外科学会雑誌, 70(増刊) (増刊), 971 - 971, Japanese

  • 【胃癌の治療 最近の考え方と治療の実際】 胃癌手術とsentinel node navigation surgery
    竹内 裕也, 才川 義朗, 和田 則仁, 高橋 常浩, 中村 理恵子, 大山 隆史, 北川 雄光
    (株)へるす出版, Sep. 2009, 消化器外科, 32(10) (10), 1577 - 1582, Japanese

  • 【手術助手に求められるもの】 腹腔鏡下幽門側胃切除術
    竹内 裕也, 才川 義朗, 和田 則仁, 大山 隆史, 高橋 常浩, 中村 理恵子, 北川 雄光
    (株)へるす出版, Jul. 2009, 消化器外科, 32(8) (8), 1349 - 1357, Japanese

  • 【オーダーメイド医療を可能にする胃癌診断】 早期胃癌 腹腔鏡下胃切除術の適応規準 Sentinel Node Navigation Surgeryの立場から
    竹内 裕也, 才川 義朗, 熊谷 厚志, 和田 則仁, 菅沼 和弘, 大山 隆史, 北川 雄光
    (株)東京医学社, May 2009, 消化器内視鏡, 21(5) (5), 755 - 758, Japanese

  • 【消化器癌〜診断・治療のすべて】 消化器癌の診断・治療 食道癌 腹部食道癌 外科治療の実際
    竹内 裕也, 才川 義朗, 大山 隆史, 平岩 訓彦, 入野 誠之, 吉川 貴久, 和田 則仁, 菅沼 和弘, 北川 雄光
    (株)へるす出版, Apr. 2009, 消化器外科, 32(5) (5), 710 - 714, Japanese

  • 【消化器疾患の病態生理 胃・十二指腸潰瘍を中心に】 胃食道逆流症(GERD)におけるQOLの観点からみた手術適応
    入野 誠之, 竹内 裕也, 才川 義朗, 和田 則仁, 菅沼 和弘, 大山 隆史, 平岩 訓彦, 吉川 貴久, 小澤 壯治, 北川 雄光
    (株)ライフ・サイエンス, Mar. 2009, Progress in Medicine, 29(3) (3), 799 - 803, Japanese

  • 食道癌根治術における血清サイトカイン値の臨床的意義の検討
    吉川貴久, 竹内裕也, 才川義朗, 和田則仁, 高橋常浩, 大山隆史, 中村理恵子, 宮庄拓, 岡本実, 山田晋吾, 横田博, 丸山征郎, 石坂彰敏, 北川雄光
    2009, General Thoracic and Cardiovascular Surgery, 57(Supplement) (Supplement)

  • The effect of aspartyl proteinase from candida albicans in duodenal ulcer induced by cysteamine in rats
    Longxue Jin, Masashi Yoshida, Yuko Kitagawa, Tetsuya Nakamura, Hideki Ishikawa, Go Wakabayashi, Minoru Tanabe, Shigeyuki Kawachi, Masahiro Shinoda, Tetsuro Kubota, Yoshiro Saikawa, Norihito Wada, Masaki Kitajima
    Jan. 2009, WOUND REPAIR AND REGENERATION, 17(1) (1), A4 - A4, English
    Summary international conference

  • 熊谷 厚志, 竹内 裕也, 才川 義朗, 伊藤 亮, 五十嵐 高広, 入野 誠之, 吉川 貴久, 津和野 伸一, 平岩 訓彦, 大山 隆史, 菅沼 和弘, 和田 則仁, 久保田 哲朗, 北川 雄光
    (一社)日本消化器内視鏡学会-関東支部, Dec. 2008, Progress of Digestive Endoscopy, 73(2) (2), 128,5 - 129,5, Japanese

  • 【手術の王道 消化管の手術】 胃・十二指腸 胃腸吻合術
    和田 則仁, 大山 隆史, 菅沼 和弘, 竹内 裕也, 才川 義朗, 久保田 哲朗, 北川 雄光
    (株)へるす出版, Nov. 2008, 消化器外科, 31(12) (12), 1803 - 1808, Japanese

  • 食道癌ハイリスク症例に対する治療法の選択 食道癌周術期管理における生体反応制御療法の有用性
    竹内 裕也, 須田 康一, 吉川 貴久, 宮庄 拓, 岡本 実, 才川 義朗, 和田 則仁, 菅沼 和弘, 平岩 訓彦, 入野 誠之, 福永 興壱, 山田 晋吾, 横田 博, 丸山 征郎, 石坂 彰敏, 北川 雄光
    (一社)日本癌治療学会, Oct. 2008, 日本癌治療学会誌, 43(2) (2), 311 - 311, Japanese

  • 【進行食道癌の治療 エビデンスレベルと治療成績の向上を目指して】 進行食道癌における鏡視下手術とセンチネルリンパ節理論の可能性
    竹内 裕也, 才川 義朗, 大山 隆史, 和田 則仁, 菅沼 和弘, 小澤 壯治, 北川 雄光
    (株)へるす出版, Oct. 2008, 消化器外科, 31(11) (11), 1605 - 1609, Japanese

  • 吉川 貴久, 須田 康一, 竹内 裕也, 入野 誠之, 平岩 訓彦, 安藤 崇史, 和田 則仁, 才川 義朗, 安斉 俊久, 森崎 浩, 武田 純三, 石坂 彰敏, 北川 雄光
    (一社)日本外科学会, Apr. 2008, 日本外科学会雑誌, 109(臨増2) (臨増2), 298 - 298, Japanese

  • カンジダ感染十二指腸潰瘍におけるAspartyl proteinaseのインヒビター投与による影響
    金 龍学, 吉田 昌, 北川 雄光, 中村 哲也, 石川 秀樹, 若林 剛, 田辺 稔, 河地 茂行, 篠田 昌宏, 久保田 哲朗, 才川 義朗, 和田 則仁, 北島 政樹
    (一社)日本創傷治癒学会, Dec. 2007, 日本創傷治癒学会プログラム・抄録集, 37回, 82 - 82, Japanese

  • S6-4. システアミンラット潰瘍モデルにおけるCandida albicans感染の治癒への影響について(第36回胃外科・術後障害研究会)
    金 龍学, 吉田 昌, 中村 哲也, 若林 剛, 島津 元秀, 田辺 稔, 河地 茂行, 才川 義朗, 和田 則仁, 北島 政樹
    一般社団法人日本消化器外科学会, 01 Oct. 2007, 日本消化器外科学会雑誌, 40(10) (10), Japanese

  • O-3-56 十二指腸潰瘍穿孔と治癒へのCandida albicans感染の影響について(胃十二指腸 症例,一般演題(口演),第62回日本消化器外科学会定期学術総会)
    金 龍学, 吉田 昌, 中村 哲也, 石川 秀樹, 若林 剛, 田辺 稔, 河地 茂行, 才川 義朗, 和田 則仁, 北島 政樹
    一般社団法人日本消化器外科学会, 01 Jul. 2007, 日本消化器外科学会雑誌, 40(7) (7), Japanese

  • 【消化器疾患の病態生理 胃・十二指腸潰瘍を中心に】胃・十二指腸におけるCandida陽性潰瘍について
    吉田 昌, 中村 哲也, 金 龍学, 石川 秀樹, 若林 剛, 田辺 稔, 河地 茂行, 篠田 昌宏, 和田 則仁, 才川 義朗, 熊井 浩一郎, 久保田 哲朗, 北川 雄光, 北島 政樹
    (株)ライフ・サイエンス, Mar. 2007, Progress in Medicine, 27(3) (3), 610 - 613, Japanese

  • Candida albicans感染による十二指腸潰瘍治癒への影響について
    金 龍学, 吉田 昌, 中村 哲也, 石川 秀樹, 若林 剛, 島津 元秀, 田辺 稔, 河地 茂行, 熊井 浩一郎, 久保田 哲朗, 才川 義朗, 和田 則仁, 亀山 香織, 北島 政樹
    (一社)日本創傷治癒学会, Dec. 2006, 日本創傷治癒学会プログラム・抄録集, 36回, 71 - 71, Japanese

  • Helicobacter pylori除菌不成功後のCandida陽性胃潰瘍の1例について
    金 龍学, 吉田 昌, 才川 義朗, 和田 則仁, 中村 哲也, 高橋 悟, 熊井 浩一郎, 久保田 哲朗, 石川 秀樹, 北島 政樹
    (一社)日本消化器内視鏡学会-関東支部, Jun. 2006, Progress of Digestive Endoscopy, 69(1) (1), 85 - 85, Japanese

  • PPS-2-055 噴門部癌術後の縦隔内再発に対しTS-1放射線同時併用療法によりCRを得た1例(胃症例1)
    清田 毅, 徳山 丞, 和田 則仁, 北條 隆, 島田 敦, 大石 崇, 磯部 陽, 窪地 淳, 萬 篤憲, 池内 駿之
    一般社団法人日本消化器外科学会, 01 Jul. 2004, 日本消化器外科学会雑誌, 37(7) (7), 1217, Japanese

  • Kuwano Yusuke, Kumai Koichiro, Matunaga Deniese Mie, San Ji Wen, Suganuma Kazuhiro, Wada Norihito, Egawa Tomohisa, Tokuyama Jo, Otani Yoshihide, Kubota Tetsuro, Kitajima Masaki, Aiura Koichi, Mukai Makio
    A case with micro gastric cancer in the remnant stomach was reported. This 57-years-old male patient was initially operated on June 1999, because of his advanced gastric cancer with surgical type 3 at the antrum, of which histological finding was moderately differentiated adenocarcinoma with a depth of pT3 (SE) and lymph node metastasis of pN2. At 1-year-follow up on June 7th, a reddish abnormal lesion was observed at lesser curvature of remnant stomach by gastroscopy. Since the biopsy specimen revealed signet-ring cell carcinoma, he was operated on July 2000. No lesion was observed macroscopically, while the histological findings indicated the lesion of signet-ring cell carcinoma of which size was 1mm. The present case was diagnosed as a micro early gastric cancer in the remnant stomach on 1-year-after the first operation for advanced gastric cancer. Follow-up endoscopy was thought to be useful not only for the recurrence of primary cancer but also to find the secondary cancer.
    Japan Gastroenterological Endoscopy Society Kanto Chapter, 2001, Progress of Digestive Endoscopy(1972), 58(2) (2), 78 - 79, Japanese

  • Masaru Kimata, Tetsuro Kubota, Yoshihide Otani, Masahiro Ongami, Yoichiro Isnikawa, Takeyoshi Yokoyama, Soichiro Issiki, Sadanori Abe, Tomohisa Egawa, Joh Tokuyama, Norihito Wada, Koichiro Kumai, Masaki Kitajima, Makio Mukai
    Springer Japan, 2000, Surgery Today, 30(2) (2), 177 - 180, English

■ Research Themes
  • マトリックス分解酵素阻害剤を用いた胃癌腹膜播種抑制に関する研究
    日本学術振興会, Grant-in-Aid for Scientific Research, 01 Apr. 1999 - 31 Mar. 2000
    Competitive research funding

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