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GOTO HironobuUniversity Hospital / Gastrointestinal SurgeryAssociate Professor
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■ Paper- Anticancer Research USA Inc., Dec. 2024, Anticancer Research, 44(12) (12), 5485 - 5493Scientific journal
- Elsevier BV, Dec. 2024, Journal of Gastrointestinal Surgery, 28(12) (12), 2001 - 2007Scientific journal
- Elsevier BV, Dec. 2024, Journal of Gastrointestinal Surgery, 101934 - 101934Scientific journal
- Elsevier BV, Dec. 2024, Journal of Gastrointestinal Surgery, 28(12) (12), 2001 - 2007Scientific journal
- Abstract Background Esophagectomy with lymphadenectomy is the primary treatment for esophageal squamous cell carcinoma (ESCC). However, intensive dissection of lymph nodes (LNs) along the recurrent laryngeal nerve (RLN) is associated with RLN palsy and pulmonary complications leading to poor survival. Therefore, this study aimed identify the risk factors for LNs metastasis along the RLN in patients with ESCC. Methods The present study included 168 patients with lower thoracic esophageal and esophagogastric junction (EGJ) squamous cell carcinoma who underwent esophagectomy with total mediastinal lymphadenectomy at Kobe University Hospital. Left/Right cervical paraesophageal (101 L/R), left/right recurrent nerve (106 recL/R), and left tracheobronchial LNs (106 tbL) were defined as LNs along the RLN. We evaluated the pathological distance between the proximal tumor boundary and the EGJ using images of the fixed specimen (PB‐EGJ length). Results LN metastasis along the RLN was observed in 19 (11%) patients. The percentage of patients with a longer PB‐EGJ length and cLNs metastasis was higher in the LNs metastasis along the RLN positive‐group than in the RLN‐negative group (p = 0.0075 and p = 0.013, respectively). The incidence of LNs metastasis along the RLN was 0% (95% confidence interval [CI] = 0–7.7%) when the PB‐EGJ length was <4 cm. Univariate analysis showed that patients with cLNs metastasis negative had a low risk for LNs metastasis along the RLN (odds ratio = 0.26 and 95% CI = 0.083–0.82). Conclusions Patients with a PB‐EGJ length <4 cm and negative for cLNs metastasis may be candidates for the omission of lymphadenectomy along the RLN.Wiley, Nov. 2024, World Journal of SurgeryScientific journal
- Abstract Developmental cyst is occasionally seen in children but are less common in adults. Complete removal of developmental cyst is necessary because there are risk of infection, squamous cell carcinoma, and recurrence due to incomplete resection. The best approach for resection of developmental cyst is still controversial. Although transsacral approach, open abdominal approach, or a combination of both have been often employed to date, reports of laparoscopic surgery have been appearing in recent years. We performed laparoscopic surgery for four patients with this disease: (i) 29‐year‐old woman with epidermoid cyst; (ii) 21‐year‐old woman with dermoid cyst; (iii) 55‐year‐old woman with epidermoid cyst; and (iv) 77‐year‐old woman with epidermoid cyst. No perioperative complications occurred and no recurrence has developed so far in any patients. Laparoscopic surgery can be considered as one of the optimal treatment options for developmental cyst.Wiley, Nov. 2024, Asian Journal of Endoscopic Surgery, 18(1) (1)Scientific journal
- Springer Science and Business Media LLC, Sep. 2024, Surgery TodayScientific journal
- Springer Science and Business Media LLC, Sep. 2024, Surgery TodayScientific journal
- Lead, Springer Science and Business Media LLC, Sep. 2024, Esophagus, 22(1) (1), 59 - 67Scientific journal
- (一社)日本サイトメトリー学会, Jul. 2024, Cytometry Research, 34(Suppl.) (Suppl.), 76 - 76, Japanese多重免疫組織化学染色法を用いた腫瘍免疫微小環境の検討と空間統計解析
- Springer Science and Business Media LLC, Jun. 2024, Surgery TodayScientific journal
- Abstract Background Herein, we report a case of gastric antrum cancer with multiple invasions to other organs that was completely cured with laparoscopic distal gastrectomy after preoperative chemotherapy in a patient with poor general condition. Case presentation An 80-year-old male patient was diagnosed with anemia during follow-up for cerebral lacunar infarction at another hospital. He was diagnosed with advanced-stage gastric antrum cancer and was referred to our hospital. On esophagogastroduodenoscopy, type 2 advanced-stage gastric cancer was detected at the greater curvature of the antrum, and the biopsy results revealed tubular adenocarcinoma. Contrast-enhanced computed tomography scan revealed multiple invasions to other organs, thick gastric wall with contrast effect, and superior mesenteric vein tumor thrombus. However, there was no evidence of distant metastasis on positron emission tomography/computed tomography scan. The clinical diagnosis was stage IVA gastric cancer. Pancreatoduodenectomy with portal vein resection could be important at this point. However, preoperative chemotherapy with S-1 and oxaliplatin was administered instead of performing extended surgery because the patient had poor general condition (performance status score of 3). The patient received three cycles of preoperative chemotherapy at the hospital along with rehabilitation and nutritional management with oral nutritional supplements. After treatment, the performance status score of the patient improved from 3 to 1. Furthermore, in terms of clinical therapeutic effect, the patient achieved partial response. Hence, laparoscopic distal gastrectomy with D2 lymph node dissection and partial transverse colectomy was performed. After surgery, the patient was admitted for oral intake on postoperative day 6 and was discharged on postoperative day 21. Based on the histopathological examination, gastric cancer had disappeared, and there were no evident malignant findings. Therefore, gastric cancer was classified as grade 3 according to the histological treatment efficacy criteria. The patient did not present with recurrence at 2 years after surgery. Conclusions By actively administering preoperative chemotherapy, minimally invasive radical surgery with maximum preservation of the surrounding organs can be performed for locally far advanced-stage gastric cancer in older patients with poor general condition.Springer Science and Business Media LLC, Jun. 2024, Surgical Case Reports, 10(1) (1)Scientific journal
- Springer Science and Business Media LLC, Jun. 2024, Langenbeck's Archives of Surgery, 409(1) (1)Scientific journal
- Springer Science and Business Media LLC, May 2024, Surgical Endoscopy, 38(7) (7), 3625 - 3635Scientific journal
- (株)日本臨床社, May 2024, 日本臨床, 82(増刊3 食道癌2024) (増刊3 食道癌2024), 532 - 536, Japanese
- Background In Japan, preoperative adjuvant chemotherapy followed by surgical resection is the standard treatment for patients with locally advanced esophageal squamous cell carcinoma. However, the risk of recurrence after surgical resection remains high. Although a randomized controlled trial evaluating the efficacy of nivolumab, a fully human monoclonal anti-programmed death 1 antibody, as postoperative adjuvant therapy after neoadjuvant chemoradiotherapy and surgery established its superior efficacy as adjuvant therapy, the efficacy for patients who received preoperative adjuvant chemotherapy has not been demonstrated. This study aims to elucidate the efficacy and safety of nivolumab as postoperative adjuvant therapy for patients with esophageal squamous cell carcinoma after preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. Methods This study is a multi-institutional, single-arm, Phase II trial. We plan to recruit 130 esophageal squamous cell carcinoma patients, who have undergone preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. If the patient did not have a pathological complete response, nivolumab is started as a postoperative adjuvant therapy within 4–16 weeks after surgery. The nivolumab dose is 480 mg/day every four weeks. Nivolumab is administered for up to 12 months. The primary endpoint is disease-free survival; the secondary endpoints are overall survival, distant metastasis-free survival, and incidence of adverse events. Discussion To our knowledge this study is the first trial establishing the efficacy of nivolumab as postoperative adjuvant therapy for patients with esophageal squamous cell carcinoma after preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. In Japan, preoperative adjuvant chemotherapy followed by surgery is a well-established standard treatment for resectable, locally advanced esophageal squamous cell carcinoma. Therefore, developing an effective postoperative adjuvant therapy has been essential for improving oncological outcomes.Lead, Public Library of Science (PLoS), Apr. 2024, PLOS ONE, 19(4) (4), e0299742 - e0299742Scientific journal
- Springer Science and Business Media LLC, Feb. 2024, Annals of Surgical Oncology, 31(6) (6), 4018 - 4018Scientific journal
- (一社)日本消化器外科学会, Feb. 2024, 日本消化器外科学会雑誌, 57(2) (2), 67 - 74, Japanese
- Background/Aim: The relationship between gastric cancer and oral health has been reported in several studies. This study aimed to determine the relationship between the postoperative prognosis of gastric cancer and oral health using preoperative tooth loss as a simple index. Patients and Methods: We conducted a single-center retrospective cohort study. Patients were divided into two groups according to the number of tooth losses. The survival curve was constructed using the Kaplan–Meier method. We also performed univariate and multivariate analyses of overall survival based on Cox proportional hazard regression to determine prognostic factors. Results: A total of 191 patients were divided into two groups: those with seven or more tooth losses and those with less than seven tooth losses. The three-year overall survival rate was 71.5% in the group with seven or more tooth losses and 87.0% in the group with less than seven tooth losses. The group with seven or more tooth losses had a significantly lower overall survival rate compared to the group with less than seven tooth losses (p=0.0014). However, in multivariate analysis, tooth loss was not identified as an independent prognostic factor whereas age, clinical T stage, CEA level, and serum albumin level were independent poor prognostic factors. Conclusion: Preoperative tooth loss was not a prognostic factor for gastric cancer after gastrectomy, but tooth loss may be a simple and useful method for evaluating frailty in patients.Anticancer Research USA Inc., Jan. 2024, Cancer Diagnosis & Prognosis, 4(1) (1), 51 - 56Scientific journal
- Lead, (株)日本臨床社, Jan. 2024, 日本臨床, 82(増刊1 ロボット支援手術) (増刊1 ロボット支援手術), 163 - 169, Japanese
- Anticancer Research USA Inc., Dec. 2023, Anticancer Research, 44(1) (1), 229 - 237Scientific journal
- Springer Science and Business Media LLC, Dec. 2023, Annals of Surgical Oncology, 31(4) (4), 2482 - 2489Scientific journal
- Springer Science and Business Media LLC, Dec. 2023, Surgery TodayScientific journal
- (株)癌と化学療法社, Dec. 2023, 癌と化学療法, 50(13) (13), 1370 - 1373, Japanese
- (株)癌と化学療法社, Dec. 2023, 癌と化学療法, 50(13) (13), 1374 - 1377, Japanese
- Anticancer Research USA Inc., Nov. 2023, Anticancer Research, 43(12) (12), 5649 - 5656Scientific journal
- Abstract There has been no reliable marker for predicting oncological outcomes in patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy (NACRT). We retrospectively analyzed 73 patients with LARC who underwent curative surgery after NACRT. The modified Glasgow prognostic score (mGPS) was assessed after NACRT, and clinical outcomes were compared between the high (mGPS = 1 or 2; n = 23) and low (mGPS = 0; n = 50) groups. Body mass index was significantly higher in the low mGPS group. The 5-year disease-free survival (DFS) rate was significantly worse in the high mGPS group than that in the low mGPS group (36.7% vs. 76.6%, p = 0.002). Univariate and multivariate analyses of DFS revealed that mGPS was the most significant predictor (p < 0.001). mGPS appears to be a reliable predictor of oncological outcomes in patients with LARC undergoing NACRT.Springer Science and Business Media LLC, Oct. 2023, Scientific Reports, 13(1) (1)Scientific journal
- BACKGROUND/AIM: In pathology, the digitization of tissue slide images and the development of image analysis by deep learning have dramatically increased the amount of information obtainable from tissue slides. This advancement is anticipated to not only aid in pathological diagnosis, but also to enhance patient management. Deep learning-based image cytometry (DL-IC) is a technique that plays a pivotal role in this process, enabling cell identification and counting with precision. Accurate cell determination is essential when using this technique. Herein, we aimed to evaluate the performance of our DL-IC in cell identification. MATERIALS AND METHODS: Cu-Cyto, a DL-IC with a bit-pattern kernel-filtering algorithm designed to help avoid multi-counted cell determination, was developed and evaluated for performance using tumor tissue slide images with immunohistochemical staining (IHC). RESULTS: The performances of three versions of Cu-Cyto were evaluated according to their learning stages. In the early stage of learning, the F1 score for immunostained CD8+ T cells (0.343) was higher than the scores for non-immunostained cells [adenocarcinoma cells (0.040) and lymphocytes (0.002)]. As training and validation progressed, the F1 scores for all cells improved. In the latest stage of learning, the F1 scores for adenocarcinoma cells, lymphocytes, and CD8+ T cells were 0.589, 0.889, and 0.911, respectively. CONCLUSION: Cu-Cyto demonstrated good performance in cell determination. IHC can boost learning efficiencies in the early stages of learning. Its performance is expected to improve even further with continuous learning, and the DL-IC can contribute to the implementation of precision oncology.Aug. 2023, Anticancer research, 43(8) (8), 3755 - 3761, English, International magazineScientific journal
- PURPOSE: Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. In recent years, the proportion of patients diagnosed with CRC at younger ages has increased. The clinicopathological features and oncological outcomes in younger patients with CRC remain controversial. We aimed to analyze the clinicopathological features and oncological outcomes in younger patients with CRC. METHODS: We examined 980 patients who underwent surgery for primary colorectal adenocarcinoma between 2006 and 2020. Patients were divided into two cohorts: younger (< 40 years old) and older (≥ 40 years old). RESULTS: Of the 980 patients, 26 (2.7%) were under the age of 40 years. The younger group had more advanced disease (57.7% vs. 36.6%, p = 0.031) and more cases beyond the transverse colon (84.6% vs. 65.3%, p = 0.029) than the older group. Adjuvant chemotherapy was administered more frequently in the younger group (50% vs. 25.8%, p < 0.01). Relapse-free survival and overall survival were similar between the groups at all stages. Moreover, in stages II and III they were also comparable, regardless of the administration of adjuvant chemotherapy. CONCLUSIONS: Younger patients with CRC have a prognosis equivalent to that of older patients. Further studies are needed to establish the optimal treatment strategies for these patients.Jul. 2023, International journal of colorectal disease, 38(1) (1), 191 - 191, English, International magazineScientific journal
- (一社)日本サイトメトリー学会, Jul. 2023, Cytometry Research, 33(Suppl.) (Suppl.), 74 - 74, Japanese深層学習に基づくイメージサイトメトリーによる直腸癌の新規予後因子の探索
- Jul. 2023, Annals of surgical oncology, 30(7) (7), 4056 - 4057, English, International magazineScientific journal
- BACKGROUND: Retrosternal reconstruction has lower risks for severe postoperative morbidities, such as gastro-tracheal fistula or esophageal hiatal hernia. We have previously reported the laparoscopic retrosternal route creation (LRRC) method, but its safety and efficacy remain unclear. METHODS: In total, 374 patients with esophageal carcinoma who underwent minimally invasive McKeown esophagectomy in the prone position between 2010 and 2021 were retrospectively reviewed. We performed a propensity score-matched analysis with the simple, nearest-neighbor method and no calipers to compare postoperative outcomes and reconstructed gastric conduit functionality between patients who underwent LRRC and counterparts who underwent posterior mediastinal reconstruction. RESULTS: After matching, 62 patients were included in the laparoscopic retrosternal group (LR group) or posterior mediastinal group (PM group). No significant differences were observed between the groups, apart from the number of robot-assisted surgeries, the extent of lymph node dissection, and the method of cervical anastomosis. There were no significant differences in the incidence of Clavien-Dindo grade ≥ 2 complications. Gastro-tracheal fistula (n = 1) and esophageal hiatal hernia (n = 2) occurred in the PM group but not in the LR group. There were no differences in the incidence of pulmonary embolism between the groups (5% vs. 5%). The postoperative anastomotic stenosis rate was similar (16% vs. 27%, p = 0.192). Endoscopic findings of reflux esophagitis (modified Los Angeles classification ≥ M) at 1 year after surgery were significantly better in the LR group (p = 0.037). CONCLUSIONS: LRRC for gastric conduit reconstruction is safe and valuable. It is associated with good reconstructed gastric conduit function.Jul. 2023, Annals of surgical oncology, 30(7) (7), 4044 - 4053, English, International magazineScientific journal
- BACKGROUND/AIM: There are several concerns about oncological contamination and technical difficulty in the laparoscopic approach for locally advanced gastric cancer. We aimed to determine the safety and usefulness of laparoscopic gastrectomy for patients with advanced gastric cancer with tumor depth greater than serosal invasion. PATIENTS AND METHODS: Sixty-two laparoscopic and 82 laparotomy gastric cancer cases surgically diagnosed as serosal or other organ invasions intraoperatively between 2011 and 2021 were included. The laparoscopic and open gastrectomy results were compared by propensity score matching using stage, preoperative chemotherapy, curative resection, surgical technique, and age as explanatory variables and laparoscopy and open resection as outcome variables. RESULTS: No difference in median operative time (341 vs. 386 minutes, p=0.24) was observed, but median blood loss (0 vs. 510 ml, p<0.001) and blood transfusion requirement (9.5 vs. 43%, p<0.001) were lower in the laparoscopic group. No difference was observed between the two groups regarding complications. Furthermore, 3-year overall survival was also similar (43 vs. 42%, p=0.74). CONCLUSION: The laparoscopic surgery results are comparable to those of open surgery in treating gastric cancer with T4a or greater depth. In addition, it is minimally invasive with less blood loss, making it a standard approach.Jul. 2023, Anticancer research, 43(7) (7), 3145 - 3152, English, International magazineScientific journal
- BACKGROUND: The effect of lymphadenectomy around the recurrent laryngeal nerve (RLN) in open oesophagectomy was demonstrated with the Efficacy Index (EI). However, it remains unclear whether this effect exists for minimally invasive esophagectomy (MIE) in the prone position. The purpose of this study is to clarify the upper mediastinal lymphadenectomy contributes to improved prognosis in patients with esophageal squamous cell carcinoma. STUDY DESIGN: This study included 339 patients with esophageal squamous cell carcinoma treated with MIE in the prone position at Kobe University or Hyogo Cancer Center from 2010 to 2015. EI for each station, correlations between metastatic L/Ns around the left RLN and RLN palsy, and survival of patients with and without upper mediastinal lymphadenectomy were investigated. RESULTS: Among 297 patients treated with upper mediastinal lymphadenectomy, Clavien- Dindo grade > II left RLN palsy occurred in 59 patients (20%). Overall, EIs for the right RLN (7.4) and left RLN (6.6) were higher than EIs for other stations. For patients with upper-third or middle-third tumors, the trend was stronger. Left RLN palsy was more likely in patients with metastatic L/Ns around the left RLN than in those without (44% vs. 15%, P < 0.0001).After propensity score-matching, 42 patients were included in each group with and without upper mediastinal lymphadenectomy. In survival analyses, the 5-year overall survival (OS) were 55% vs. 35% and cause-specific survival (CSS) rates were 61% vs. 43% for the patients with and without upper mediastinal lymphadenectomy respectively. Significant differences were confirmed in survival curves (OS; P = 0.03 and CSS; P = 0.04, respectively). CONCLUSIONS: Upper mediastinal lymphadenectomy contributes to improved prognosis with high EIs in MIE in the prone position.Jun. 2023, Journal of the American College of Surgeons, English, International magazineScientific journal
- Lead, Jun. 2023, Annals of surgical oncology, 30(6) (6), 3803 - 3804, English, International magazineScientific journal
- BACKGROUND: Although transanal total mesorectal excision (TaTME) is a promising treatment for low rectal cancer, it is considered technically demanding, and the number of cases required to become proficient in TaTME remains unknown. The purpose of this study was to assess the TaTME learning curve based on the total mesorectal excision completion time. STUDY DESIGN: This retrospective analysis comprised 128 individuals who received TaTME between September 2016 and December 2021. The cumulative sum method was used to generate the learning curve. The duration of the procedure from the beginning to the end of the circumferential rendezvous was used to define the total mesorectal excision completion time. RESULTS: The learning curve consists of 3 phases: phase I (learning phase: cases 1 to 38), phase II (consolidation phase: cases 39 to 70), and phase III (maturing phase: cases 71 to 128). As the phases varied, both the overall operative time and total mesorectal excision completion time decreased considerably. Through the 3 phases of TaTME, intraoperative adverse events decreased, and in phase III, none occurred. Only 1 instance of local recurrence occurred during phase III, and none occurred during phase I or II. CONCLUSIONS: After 70 operations, the surgeon could join the mastery phase of TaTME based on the total mesorectal excision completion time. After the mastering phase began, there were no intraoperative negative occurrences. From the beginning, the oncological safety could be guaranteed.May 2023, Journal of the American College of Surgeons, 236(5) (5), 1054 - 1063, English, International magazineScientific journal
- PURPOSE: Narrow pelvis, tumor diameter, and obesity have been reported as clinical variables correlated with the difficulty of conventional laparoscopic low anterior resection (Lap-LAR). A two-team transanal total mesorectal excision (TaTME) approach where the transabdominal and TaTME are performed simultaneously might reduce the difficulty associated with these factors. This study aimed to clarify the factors associated with the longer time required for TME (TME time) in conventional Lap-LAR and a two-team approach for TaTME. METHODS: We analyzed 52 patients with rectal carcinoma treated with Lap-LAR and 35 patients treated with TaTME. We performed simple linear regression analysis to assess the association between TME time and bony pelvic size using 3D pelvimetry, longest tumor diameter, and body mass index (BMI). RESULTS: Linear regression analysis demonstrated a highly significant association between TME time and obstetric conjugate (R2 = 0.098, P = .024) and BMI (R2 = 0.307, P < .001) in the Lap-LAR group, while no significant association was observed in the TaTME group. Male patients, who had a narrower bony pelvis and higher BMI than female patients, had longer TME time than female patients in the Lap-LAR group (213 minutes vs 172 minutes, P = .021), while the TME time of male and female patients did not differ in the TaTME group (122 minutes vs 108 minutes, P = .451). The TME time in the TaTME group was significantly shorter than that in the Lap-LAR group (121 minutes vs 197 minutes, P < .001). CONCLUSION: A two-team TaTME approach provided a shorter TME time compared to conventional Lap-LAR, regardless of pelvic size and BMI.Apr. 2023, Asian journal of endoscopic surgery, 16(2) (2), 189 - 196, English, Domestic magazineScientific journal
- BACKGROUND: Esophagectomy for esophageal carcinoma is associated with higher morbidity and mortality rates than other gastrointestinal surgeries. Smoking is an established risk factor for postoperative complications after esophagectomy. This study aimed retrospectively to investigate the impact of smoking status on short- and long-term outcomes for patients undergoing thoracoscopic esophagectomy in the prone position (TEP) for esophageal carcinoma. METHODS: In this study, 234 patients with esophageal carcinoma who underwent TEP between 2012 and 2020 were divided into two groups based on smoking status (current or non-current smokers and the Brinkman index) by patients' declarations. Postoperative complications (Clavien-Dindo classification grade ≥2), overall survival (OS), and disease-free survival (DFS) were compared between smoking statuses. RESULTS: The rates of postoperative complications did not differ significantly between the two groups (current smoker vs non-current smoker; Brinkman index ≥800 vs <800). The rate of postoperative pneumonia was higher in the combination group of current and higher Brinkman index (≥800) smokers than in the other group (25.0 % vs 11.8 %; P = 0.036). Multivariate analysis showed that smoking status was an independent risk factor for postoperative pneumonia (hazard ratio, 0.41; 95 % confidence interval, 0.18-0.93; P = 0.037). According to the long-term outcomes, no significant differences in OS and DFS were observed between the smoking statuses. CONCLUSIONS: The combination of current smoking and heavy smoking history is a risk factor for postoperative pneumonia in patients who have esophageal carcinoma treated with TEP, although no correlation was observed between the long-term outcomes and smoking status.Lead, Apr. 2023, Annals of surgical oncology, 30(4) (4), 2202 - 2211, English, International magazineScientific journal
- PURPOSE: Laparoscopic surgery for low rectal cancer is often challenging. Transanal total mesorectal excision (TaTME) and robotic surgery have been introduced to overcome the technical difficulties in laparoscopic surgery and achieve more favorable outcomes. Hybrid robotic surgery, which combines TaTME with the abdominal robotic approach, incorporates the advantages of each of these surgical techniques and might achieve less invasive and safer surgery. This study evaluated the safety and feasibility of hybrid robotic surgery with TaTME (hybrid TaTME). METHODS: We retrospectively reviewed 162 TaTME cases performed at our department from September 2016 to May 2022. Among them, 92 cases of conventional TaTME and 30 of hybrid TaTME were eligible. We used propensity score matching analysis (PSM) to adjust for patients' characteristics and compared the short-term outcomes of the two treatment groups. RESULTS: Twenty-seven cases in each group were extracted using PSM. The operation time in hybrid TaTME was comparable to that in conventional TaTME. There was no significant difference in the postoperative hospital stay between the two groups. Other intra- and post-operative outcomes were also comparable between the two groups. Furthermore, no significant differences were observed between the two groups in the curative resection and recurrence rates. CONCLUSION: Hybrid TaTME for low rectal cancer was as favorable as conventional TaTME in producing satisfactory short-term outcomes. However, furthermore, larger-scale studies conducted over longer study periods are needed to evaluate the validity of the findings.Mar. 2023, Langenbeck's archives of surgery, 408(1) (1), 129 - 129, English, International magazineScientific journal
- PURPOSE: This study aimed to compare motions of the laparoscope tip during a laparoscopic task in a training box using a recent joystick-guided robotic scope holder to those manipulated by human scopists. We hypothesized that laparoscopic manipulation could be positively affected by robotic scope holders due to the elimination of unintentional movement. METHODS: Twelve surgeons participated as operators, and eight medical doctors participated in this study. Among the human scopists, five were trained surgeons and three were novices who had no experience with laparoscopic surgery. A validated laparoscopic task was used to evaluate the path length of the laparoscope tip using an optical position tracker and operative time. The operators performed the designated camera task under three different laparoscopic manipulations: using a joystick-guided robotic scope holder, expert human scopists, and novice scopists. RESULTS: The median path lengths (cm) of the laparoscopic tip were 94.0, 110.0, and 122.2 in the robotic scope holder, expert, and novice groups, respectively. The path lengths in the robotic scope holder group were significantly shorter than those in the other groups (P < .01). The median operative times (seconds) were 136.6, 66.4, and 62.3 in the robotic scope holder, expert, and novice groups, respectively. The operative time of the robotic scope holder group was significantly longer than that of the other groups (P < .001). CONCLUSION: A robotic scope holder can provide shorter camera movement owing to the stable holding and intentional scope manipulation by the operator, although it requires a longer operative time than a human assistant.Feb. 2023, Surgical innovation, 15533506231157039 - 15533506231157039, English, International magazineScientific journal
- BACKGROUND: Although lateral pelvic lymph node dissection (LLND) might be an effective approach for patients with rectal cancer with lateral lymph node metastasis, it is technically challenging because of the anatomical complexity and location of the deep pelvis. An assistance by transanal approach might be useful for a successful LLND. METHODS: From September 2016 to May 2021, 39 patients with low rectal cancer underwent transanal total mesorectal excision with LLND. Among them, 18 patients underwent LLND using a conventional laparoscopic approach alone, while the remaining 21 underwent LLND using both conventional and transanal approaches. Their clinical outcomes were retrospectively compared. RESULTS: The operation time for LLND on each side was significantly shorter in the transanal group (105 min vs. 54 min, P < 0.001). The intraoperative blood loss was also significantly less in the transanal group (40 g vs. 0 g, P = 0.031). The rate of overall postoperative complications ≥ grade II according to the Clavien-Dindo classification was significantly less in the transanal group (66.7% vs. 28.6%, odds ratio: 5.000, 95% confidence intervals: 1.313-19.047, P = 0.040). The number of harvested lateral lymph nodes in both groups was similar (8.5 vs. 8, P = 0.544). CONCLUSION: The transanal approach for LLND reduced operative time, blood loss, and morbidity compared with the conventional approach alone in a cohort of patients with rectal cancer.Feb. 2023, Surgical endoscopy, 37(2) (2), 1562 - 1568, English, International magazineScientific journal
- Although a therapeutic response to neoadjuvant chemoradiotherapy (NACRT) is important to improve oncological outcomes after surgery in patients with locally advanced rectal cancer, there is no reliable predictor for this. The Wnt/β-catenin signal is known to be crucial for the tumorigenesis of colorectal cancer. This study aimed to investigate the association of Wnt/β-catenin signal activation with a pathological response to NACRT. The immunohistochemical expression of nuclear and membranous β-catenin was analyzed in biopsy samples obtained from 60 patients with locally advanced rectal cancer who received curative surgery following NACRT. The association of Wnt/β-catenin signal activation with their clinical outcomes was investigated. Notably, the body mass index of these patients was significantly higher in the low nuclear β-catenin expression group. Moreover, patients in the high nuclear β-catenin expression group tended to have more advanced disease and a higher rate of positive vascular invasion than those in the low expression group. Furthermore, the rate of good histological responses was significantly higher in the low nuclear β-catenin expression group (72% vs. 37.1%, p < 0.01). Overall, relapse-free survival tended to be better in patients with low nuclear/high membranous β-catenin expression (n = 9) than in other individuals (n = 51) (p = 0.093 and p = 0.214, respectively). Activation of the Wnt/β-catenin signal pathway represented by nuclear β-catenin accumulation was significantly associated with a poor response to NACRT in patients with rectal cancer. Analysis of nuclear β-catenin accumulation before starting treatment might help predict the therapeutic response to NACRT.Jan. 2023, Biomedicines, 11(1) (1), English, International magazineScientific journal
- 2023, 日本外科学会定期学術集会(Web), 123rd局所進行直腸癌術前療法における腫瘍内レジデントメモリーCD8+T細胞の動態とその役割
- BACKGROUND/AIM: Neoadjuvant chemotherapy (NAC) for advanced gastric cancer (GC) and esophagogastric junction cancer (EGC) is expected to effectively control the tumor; however, histological tumor response and immune function markers as prognostic factors for NAC remain unknown. This study assessed the prognostic significance of histological response and immune function markers in patients undergoing NAC for GC and EGC. PATIENTS AND METHODS: Forty-two patients who underwent NAC followed by surgical resection for operable advanced GC or EGC from January 2007 to December 2019 were divided into two groups based on histological response. Overall survival (OS), tumor response, and immune function markers, such as the neutrophil/lymphocyte ratio (NLR), were the outcomes analyzed. RESULTS: The 5-year OS for Grade 2b-3 (n=10, responder group) according to the Japanese Gastric Cancer Classification was 72.0% with a favorable prognosis, compared with 33.3% for Grade 0-1a (n=18), and 46.8% for Grade 1b-2a (n=14) in the non-responder group. There was no significant difference in the background between the two groups regarding clinical status or immune function markers. In a multivariate analysis of immune function markers, the NLR value before NAC was significantly associated with prognosis (p=0.048). Patients with an NLR value <3.4 had a favorable OS (p=0.03). CONCLUSION: Histological response scores for Grade 2b or higher may help predict a favorable prognosis for patients undergoing NAC for advanced GC and EGC. The outcomes may be further improved by considering NLR values.2023, In vivo (Athens, Greece), 37(1) (1), 378 - 384, English, International magazineScientific journal
- PURPOSE: Rectal or anal canal adenocarcinoma with inguinal lymph node metastasis (ILNM) is rare and is associated with poor prognostic outcomes. This study aimed to elucidate the clinical significance of neoadjuvant therapy followed by selective inguinal lymph node dissection and total mesorectal excision for rectal or anal canal adenocarcinoma with clinically suspected ILNM. METHODS: This study enrolled 15 consecutive patients who underwent neoadjuvant therapy and curative resection for rectal or anal canal adenocarcinoma with clinically suspected ILNM between 2005 and 2019 at a single institution. Inguinal lymph node dissection was selectively performed on the side of suspected metastasis before neoadjuvant therapy. Short- and long-term outcomes were retrospectively reviewed. RESULTS: Out of the15 patients, 11 were treated with neoadjuvant chemoradiation, three with chemotherapy, and one with chemoradiation followed by chemotherapy. Fluorodeoxyglucose (FDG)-positron emission tomography (PET) scans were performed after neoadjuvant therapy in 14 patients. Five patients had negative FDG accumulation in inguinal lymph nodes on FDG-PET scan, and their inguinal lymph nodes were also pathologically negative for metastasis. Of the nine patients who had positive FDG accumulation, four had pathologically positive inguinal lymph nodes. Seven patients (46.7%) had inguinal seroma postoperatively. Five-year-overall survival was 77.5%, and 5-year-relapse-free survival was 64.2%. No patient had a recurrence in the inguinal region. CONCLUSION: In patients with rectal or anal canal adenocarcinoma associated with clinical ILNM, radical resection with neoadjuvant therapy provides a good long-term survival.Dec. 2022, Langenbeck's archives of surgery, 408(1) (1), 2 - 2, English, International magazineScientific journal
- (株)癌と化学療法社, Dec. 2022, 癌と化学療法, 49(13) (13), 1711 - 1713, Japanese
- BACKGROUND: Many patients with esophageal squamous cell carcinoma (ESCC) have obstructive ventilatory disorder (OVD), which is considered a risk factor for postoperative pneumonia. It has been reported that thoracoscopic esophagectomy in the prone position (TEP) is less invasive and is associated with fewer postoperative respiratory complications compared with open esophagectomy. This matched-cohort study aimed to elucidate the safety and oncologic outcomes of ESCC patients with OVD who undergo TEP. METHODS: In this matched-cohort study, 237 patients with ESCC who underwent TEP between 2010 and 2018 were divided into two groups based on forced expiratory volume in 1 s/forced vital capacity. Postoperative complications (Clavien-Dindo classification grade II or higher), overall survival (OS), and disease-free survival (DFS) were compared between the two groups. RESULTS: Based on their propensity scores, 75 patients with normal respiratory function (NRF) and 75 with OVD were selected. The rates of postoperative pneumonia were not significantly different between the two groups (NRF group vs OVD group: 18.7% vs 18.7%; P = 1.000). The rates of recurrent laryngeal nerve palsy and anastomotic leakage were also not significantly different (NRF group vs OVD group: 12.0% vs 18.7%, P = 0.365; 18.7% vs 18.7%, P = 1.000). The 5-year OS and DFS rates in the NRF vs OVD groups were 66.2% vs 54.9% and 63.5% vs 52.9%, respectively, with no significant differences (P = 0.421, 0.197). CONCLUSIONS: TEP can be safely performed on ESCC patients with OVD and can result in an oncological efficiency equal to that of the NRF group.Lead, Dec. 2022, Surgical endoscopy, 36(12) (12), 8834 - 8842, English, International magazineScientific journal
- [A Case of Pathological Complete Response after Conversion Surgery for HER2-Positive Advanced Gastric Cancer with Multiple Distant Metastases].The patient is a 70's man. Esophagogastroduodenoscopy and contrast-enhanced CT scan of the abdomen revealed gastric cancer, 2 liver metastases, and peritoneal dissemination. He was diagnosed with unresectable advanced gastric cancer and received 5 courses of chemotherapy(CapeOX plus T-mab). The primary tumor size had reduced, and liver metastases and peritoneal dissemination were not detectable, so laparoscopic distal gastrectomy and partial hepatectomy were performed. Histopathological findings revealed no viable cancer cells in either the primary tumor or the hepatic resection site, and the histological response was Grade 3. The patient has been recurrence-free for 6 months since the surgery. Even in Stage Ⅳ gastric cancer with multiple distant metastases, long-term survival may be expected by conversion surgery after response to chemotherapy.Dec. 2022, Gan to kagaku ryoho. Cancer & chemotherapy, 49(13) (13), 1711 - 1713, Japanese, Domestic magazineScientific journal
- PURPOSE: No study has focused on the safety and feasibility of our previously developed open-window suturing technique to close mucosal defects on the pancreatic side after endoscopic submucosal dissection from the opened duodenal wall. This study aimed to evaluate the safety and usefulness of laparoscopic endoscopic cooperative surgery for duodenal tumors for treating superficial non-ampullary duodenal epithelial tumors on the pancreatic side of the duodenum. METHODS: This retrospective study included 61 consecutive patients who underwent surgery during August 2014-November 2021. After dissection when the tumor was on the pancreatic side, we sutured the mucosal defect from the opened duodenal wall. A preoperative endoscopic pancreatic stent was placed for tumors within 1 cm of the ampulla of Vater. The surgical outcomes were compared between tumors on the pancreatic and non-pancreatic sides. RESULTS: There were 27 and 34 patients with tumors on the pancreatic and non-pancreatic sides, respectively. The patient characteristics were similar. Preoperative pancreatic stents were placed in four patients in the pancreatic side group. The median operative time was significantly longer on the pancreatic side than in the non-pancreatic side group (241 vs. 209 min, P = 0.02). In one patient in the pancreatic side group, an intraoperative injury of the ampulla of Vater was successfully treated with intraoperative management. There were no significant differences in the incidence of postoperative grade II or higher complications between the groups. CONCLUSIONS: Laparoscopic endoscopic cooperative surgery for duodenal tumors for treating superficial non-ampullary duodenal epithelial tumors on the pancreatic side is safe and feasible.Nov. 2022, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 26(11) (11), 2266 - 2273, English, International magazineScientific journal
- BACKGROUND/AIM: Although survival in cases with early recurrence after curative resection of colorectal cancer has been persistently poor, the risk factors for early recurrence remain unknown. PATIENTS AND METHODS: A total of 1,043 patients with stage I-III colorectal cancer underwent curative resection at Kobe University Hospital between April 2007 and September 2020. Of these, 122 patients developed recurrence: 57 had early recurrence (<1 year after surgery) and 65 patients had late recurrence (≥1 year after surgery). The clinicopathological features were compared between the groups and the risk factors for early recurrence were analyzed. RESULTS: Overall survival both from the date of recurrence and from the date of surgery were significantly worse in the early recurrence group. The proportion of the patients with ≥100 g of intraoperative blood loss, blood transfusion, and postoperative complications were significantly higher in the early recurrence group. R0 resection was achieved more frequently in the late recurrence group. Multivariate analysis revealed that no adjuvant chemotherapy, elevated preoperative CA19-9, blood transfusion, and the occurrence of the postoperative complication were independent risk factors for early recurrence. CONCLUSION: Early recurrence after curative resection of colorectal cancer was associated with worse overall survival. Adjuvant chemotherapy might be beneficial for patients with risk factors of early recurrence to improve prognosis.Nov. 2022, Anticancer research, 42(11) (11), 5553 - 5559, English, International magazineScientific journal
- Oct. 2022, Annals of surgical oncology, 29(11) (11), 6867 - 6868, English, International magazineScientific journal
- BACKGROUND: Multidisciplinary treatment combining neoadjuvant treatment (NAT) and surgery has slightly improved the prognosis of patients with esophageal squamous cell carcinoma (ESCC). Although various biomarkers targeting nutrition and inflammation are associated with cancer prognosis, most studies have focused on conditions prior to NAT. Developing real-time and sensitive biomarkers that monitor changes in systemic conditions during NAT is important. We established a novel nutritional and inflammatory index, represented as the albumin to derived neutrophil-to-lymphocyte ratio (Alb-dNLR), and calculated the change in Alb-dNLR (ΔAlb-dNLR) during neoadjuvant chemotherapy (nCT). In this study, we aimed to evaluate whether ΔAlb-dNLR is associated with prognosis in patients with ESCC. METHODS: We investigated 172 patients who underwent nCT before esophagectomy between April 2010 and March 2018. The dNLR was calculated as the ratio of neutrophil count to (white blood cell count - neutrophil count), Alb-dNLR was calculated by dividing the serum albumin level by the dNLR, and ΔAlb-dNLR was evaluated by dividing the post-Alb-dNLR by the pre-Alb-dNLR. Patients were divided into 'high' and 'low' groups according to the ΔAlb-dNLR. RESULTS: Thirty-nine patients (22.7%) had a low ΔAlb-dNLR (≤ 0.8), and the 5-year overall survival (OS) rates in patients with low and high ΔAlb-dNLR were 38.1% and 53.6%, respectively (p = 0.0072). Multivariate analyses demonstrated that estimated blood loss (p = 0.044), pathological T stage (p = 0.0005), pathological N stage (p = 0.017), and ΔAlb-dNLR (p = 0.005) were independent prognostic factors for OS. CONCLUSIONS: ΔAlb-dNLR is a useful prognostic factor for OS in patients with ESCC receiving nCT.Oct. 2022, Annals of surgical oncology, 29(11) (11), 6860 - 6866, English, International magazineScientific journal
- Oct. 2022, Annals of surgical oncology, 29(11) (11), 6869 - 6870, English, International magazineScientific journal
- The risk factors for delayed gastric emptying (DGE) following gastrectomy are unclear. This study aimed to investigate the risk factors for DGE and the severity of DGE. We retrospectively evaluated 412 patients who underwent gastrectomy for gastric cancer between 2011 and 2019. The cases were classified into the DGE (n = 27) and non-DGE (n = 385) groups; the DGE group was further classified into two subgroups based on nasogastric tube insertion as an indicator of severity. For determining the relationship between resected stomach volume and DGE, we calculated the area of each surgical specimen using the ImageJ software. Female sex (odds ratio [OR] 2.55; 95% confidence interval [CI] 1.09-5.93; P = 0.03), diabetes (OR 2.38; 95% CI 1.02-5.57; P = 0.03), and distal gastric tumors (OR 2.61; 95% CI 1.10-6.19; P = 0.02) were identified as independent risk factors by multivariate analysis. The duration of hospital stay was longer in the DGE group than in the non-DGE group (29 vs. 15 days, P < 0.01). Overall, 24 cases of DGE (89%) were found in more than 1 week following surgery. No correlation was observed between clinical features and the severity of DGE. The resected area in the DGE group was significantly larger than that in the non-DGE group (198.0 vs. 173.9 cm2, P = 0.03). In conclusion, DGE was frequently observed in females and in patients with diabetes and distal gastric tumors. Most of the DGE cases occurred after 7-14 days of surgery, patients who are discharged early should be informed to seek hospitalization if they have symptoms caused by DGE.Sep. 2022, Scientific reports, 12(1) (1), 15903 - 15903, English, International magazineScientific journal
- 金原出版(株), Aug. 2022, 手術, 76(9) (9), 1475 - 1488, Japanese
- BACKGROUND: The eighth edition of the American Joint Committee on Cancer (AJCC) tumor node metastasis (AJCC-TNM 8th) system adopted the newly separate post-neoadjuvant pathologic stage group (ypTNM). However, it is not compatible with the Japanese pathologic classification after neoadjuvant chemotherapy (JPN-CT-pTNM). The aim of this study is to clarify the subjects of the AJCC-ypTNM 8th and propose a unification of the AJCC and Japanese systems to create novel AJCC-CT-pTNM 8th. METHODS: Participants were 304 esophageal squamous cell carcinoma (ESCC) patients who underwent neoadjuvant chemotherapy followed by 3 stage esophagectomy between 2010 and 2019. Predictive probabilities of pN, pM in AJCC-ypTNM 8th and JPN-CT-pTNM 11th systems were evaluated to propose novel system. RESULTS: In training data from 234 patients, the overall survival rate was statistically better for ypStage IIIA than ypStage II (P = 0.040) resulting in staging inversion in AJCC-ypTNM 8th. Predictive probability of pathological N status in AJCC-ypTNM 8th (Akaike Information Criterion: AIC = 979.53) was superior to that in JPN-CT-pTNM 11th (AIC = 999.07). In AJCC-ypTNM 8th, 71% (15/21) of ypM1 diseases were supraclavicular lymph nodes (No. 104 L/N as regional in JPN-CT-pTNM 11th) metastases with considerably good prognosis. The predictive probability of the novel AJCC-CT-pTNM 8th [unification of ypStage II and IIIA, conversion of supraclavicular L/Ns metastases from ypM to ypN] (AIC = 1054.24) was superior to that of the existing AJCC-ypTNM 8th (AIC = 1070.74). The feasibility of novel system was validated using test data from 70 patients. CONCLUSIONS: Unification of the AJCC and Japanese systems yields a simpler and more precise predictive system after neoadjuvant chemotherapy.Aug. 2022, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 48(8) (8), 1760 - 1767, English, International magazineScientific journal
- PURPOSE: Despite the increasing incidence of adenocarcinoma of the esophagogastric junction, laparoscopic proximal gastrectomy with lower esophagectomy (PGLE) is not widely accepted owing to the lack of standardized reconstruction techniques. In this study, we developed a new reconstruction method named y-shaped overlap esophagogastric tube reconstruction, which reproduces an angle of His and a pseudo-fornix, to be used in laparoscopic transhiatal PGLE. This study aimed to determine the feasibility of this novel reconstruction method. METHODS: This retrospective study included the analysis of short- and mid-term surgical outcomes of 30 consecutive patients with Siewert type II esophagogastric junction adenocarcinoma who underwent laparoscopic PGLE with y-shaped overlap esophagogastric tube reconstruction from April 2015 to August 2020. A novel method was used to form a 6-cm pseudo-fornix and an angle of His using the distal esophagus and a long gastric tube. RESULTS: The median operation time was 369 min, and the median blood loss was 28 mL. The median follow-up period after surgery was 37 months. Although two patients experienced postoperative anastomotic leakage, none of the patients developed stenosis. One patient experienced moderate reflux symptoms, whereas four patients developed moderate reflux esophagitis based on the 1-year follow-up endoscopic examination; the condition of all patients could be efficiently controlled with medication. CONCLUSION: The short- and mid-term surgical outcomes of y-shaped overlap esophagogastric tube reconstruction reflected the feasibility of this simple technique and suggested its potential utility as a reconstruction alternative for Siewert type II tumors.Aug. 2022, Langenbeck's archives of surgery, 407(5) (5), 1881 - 1890, English, International magazineScientific journal
- BACKGROUND: Postoperative complications affect long-term prognosis in patients with esophageal squamous cell carcinoma (ESCC). Although a comprehensive estimator can predict long-term prognosis, the Clavien-Dindo classification system, a widely used approach to evaluate complications, assesses each complication individually. We aimed to clarify the utility of the comprehensive complication index (CCI) on predicting the overall survival (OS) of patients with ESCC following minimally invasive esophagectomy (MIE). METHODS: This was a retrospective study of patients undergoing MIE for ESCC in the prone position between January 2011 and December 2018. Multivariate analyses using the Cox proportional hazards model were performed to determine independent risk factors for OS. RESULTS: The study cohort included 229 patients who were categorized into patients with CCI values of ≥ 33.7 (CCI high) and < 33.7 (CCI low) by receiver-operating characteristic (ROC) curve analysis. There were no significant differences between the two groups according to clinicopathological factors, such as sex, age, tumor location, tumor depth, lymph node metastasis, and neoadjuvant chemotherapy. The intraoperative transfusion rate in the CCI high group was significantly higher than in the CCI low group. The 5 year OS rate was significantly lower in the CCI high group than in the CCI low group (49.5% vs. 65.7%, p = 0.030). By multivariate analyses, age, tumor depth, lymph node metastasis, and the CCI were independent predictors of OS. CONCLUSIONS: Comprehensive assessment of postoperative complications using the CCI was useful in predicting OS of patients undergoing MIE for the ESCC.Jul. 2022, Esophagus : official journal of the Japan Esophageal Society, 19(3) (3), 410 - 416, English, Domestic magazineScientific journal
- BACKGROUND: Technical difficulties are occasionally encountered when performing conventional minimally invasive esophagectomy and robot-assisted minimally invasive esophagectomy in patients with a narrow thoracic cavity. Thoracic cavity-to-cage ratio is an indicator of thoracic cavity length. We hypothesized that the thoracic cavity-to-cage ratio could be a predictor of technical difficulties in conventional minimally invasive esophagectomy and robot-assisted minimally invasive esophagectomy. METHODS: We evaluated 340 patients who underwent minimally invasive esophagectomy for esophageal squamous cell carcinoma between April 2010 and March 2021. Thoracic cavity-to-cage ratio was calculated as the diameter of the thoracic cavity to that of the thoracic cage at the brachiocephalic vein, tracheal bifurcation, and inferior right pulmonary vein levels. Moreover, thoracic cavity-to-cage ratio score, which is an indicator of the whole thoracic cavity length based on the thoracic cavity-to-cage ratio at the 3 levels, was defined. The thoracic procedure time was considered an indicator of surgical difficulty. RESULTS: We divided the patients into the conventional minimally invasive esophagectomy (n = 295) and robot-assisted minimally invasive esophagectomy (n = 45) groups. The patients in each group were divided into 2 cohorts according to median thoracic procedure time. Based on multivariate analysis, body mass index (P = .0007), clinical N stage (P = .0191), and thoracic cavity-to-cage ratio score (P = .0005) were independent factors for thoracic procedure time in the conventional minimally invasive esophagectomy group. Moreover, thoracic cavity-to-cage ratio at the tracheal bifurcation level (P = .0331) was the only independent factor for thoracic procedure time in the robot-assisted minimally invasive esophagectomy group. CONCLUSION: Thoracic cavity-to-cage ratio could be a predictor of technical difficulties in both conventional minimally invasive esophagectomy and robot-assisted minimally invasive esophagectomy.Jul. 2022, Surgery, 172(1) (1), 145 - 149, English, International magazineScientific journal
- Jun. 2022, Ann Surg Oncol, 29(6) (6), 3683
- BACKGROUND: Minimally invasive esophagectomy (MIE) for esophageal cancer patients with sarcopenia is associated with a high risk of perioperative complications; however, the relationship between sarcopenia and the survival of esophageal cancer patients remains controversial. In this study, we aimed to develop a stratifying marker for sarcopenia to precisely predict patients' prognosis. METHODS: We retrospectively studied 135 patients who underwent thoracoscopic esophagectomy at Kobe University Hospital from 2011 to 2015 and who were preoperatively diagnosed with or without sarcopenia based on the Asian Working Group for Sarcopenia index. Creatinine levels and albumin as measures of skeletal muscle volume and nutritional status, respectively, were used to develop a marker to be used for stratifying sarcopenic patients based on prognosis. RESULTS: Of the 135 patients, 35 were diagnosed with sarcopenia and 100 were not. We combined the creatinine and albumin levels (Cr × Alb) as a stratifying marker for sarcopenia, and extracted sarcopenic patients with values below the Cr × Alb cut-off as the actual sarcopenic group. The 5-year overall survival (OS) rates of the actual and non-actual sarcopenic groups were 28.9% and 58.9%, respectively (p = 0.0005), and the 5-year disease-free survival rate of the actual sarcopenic group was 34.1%, and 62.8% (p = 0.0106) for the non-actual sarcopenic group. This stratified sarcopenia model was an independent prognostic factor and was superior to sarcopenia alone for OS. CONCLUSIONS: In patients undergoing MIE, preoperative measurement of Cr × Alb may be a prognostic stratification marker for patients with sarcopenia.Jun. 2022, Annals of surgical oncology, 29(6) (6), 3670 - 3681, English, International magazineScientific journal
- Although transperineal minimally invasive abdominoperineal resection (tp-APR) based on the concept of transanal total mesorectal excision has recently been used for rectal cancer, the operative procedure has not been standardized to date due to its technical difficulty. The tp-APR procedure used by the authors for a male patient with low rectal cancer is presented in this video.May 2022, Annals of surgical oncology, 29(5) (5), 3065 - 3065, English, International magazineScientific journal
- BACKGROUND/AIM: Esophageal squamous cell carcinoma (ESCC) is a deadly malignant disease. This study examined whether the platelet-to-lymphocyte ratio (PLR) can be used as a biomarker to evaluate prognosis in patients with advanced ESCC following neoadjuvant chemotherapy (NAC) and undergoing minimally invasive esophagectomy (MIE). PATIENTS AND METHODS: We examined 174 patients between January 2010 and December 2015 at the Kobe University. Of these, 121 were treated with NAC. The PLR cutoff was determined through receiver-operating characteristic curve analysis. Univariate and multivariate analyses were conducted to identify prognostic factors for overall survival (OS). RESULTS: The PLR cutoff for OS in 121 patients was 169.6. Patients with PLR ≥169.6 had worse 5-year OS rates (31.1%) than those with a PLR <169.6 (61.1%, p=0.001). Multivariate analysis revealed that a PLR of ≥169.6 was an independent factor for poor prognosis. CONCLUSION: PLR is an independent prognostic factor for patients with ESCC after NAC and MIE.May 2022, Anticancer research, 42(5) (5), 2775 - 2782, English, International magazineScientific journal
- BACKGROUND: Multidisciplinary treatment for esophageal squamous cell carcinoma (ESCC) has improved outcomes, but the prognosis for ESCC remains poor. Nutritional and inflammatory indicators are reported to be associated with cancer prognosis. The combination of albumin and the derived neutrophil-to-lymphocyte ratio (Alb-dNLR) score was established to measure the immune system and nutritional status. The authors hypothesized that the Alb-dNLR score could be a new reliable prognostic factor for ESCC patients. METHODS: The study evaluated 269 patients who underwent esophagectomy between April 2010 and March 2018, including 185 patients who received neoadjuvant chemotherapy. The Alb-dNLR score was calculated using serum albumin and the dNLR. The dNLR was calculated as neutrophils to (leukocyte-neutrophil count). The cutoff values of the albumin and dNLR for overall survival (OS) were determined using the receiver operating characteristic curve. Patients were divided into "high" and "low" groups according to the Alb-dNLR score. RESULTS: A high Alb-dNLR score was found in 61 cases (22.7%). The 5-year OS was 34% in the high Alb-dNLR group and 66.2% in the low Alb-dNLR group (p < 0.0001). The 5-year cause-specific survival (CSS) was 51.5% in the high Alb-dNLR group and 74.7% in the low Alb-dNLR group (p < 0.0001). Multivariate analyses demonstrated that the Alb-dNLR score was an independent prognostic factor for OS (hazard ratio [HR], 2.198; 95% confidence interval [CI], 1.460-3.263; p = 0.0002) and CSS (HR, 1.733; 95% CI, 1.035-2.835; p = 0.0371). CONCLUSIONS: The Alb-dNLR score is an extremely useful, easy-to-use parameter to predict OS and CSS for ESCC patients.Apr. 2022, Annals of surgical oncology, 29(4) (4), 2663 - 2671, English, International magazineScientific journal
- PURPOSE: Laparoscopic local resection for gastrointestinal stromal tumors (GISTs) near the esophagogastric junction (EGJ) increases the risk of injuring the EGJ. We investigated the safety of laparoscopic local resection for GISTs near the EGJ according to the distance from the EGJ to the tumor edge. METHODS: We retrospectively evaluated 40 patients who had undergone laparoscopic local resection for GISTs near the EGJ between January 2009 and December 2019. After excluding 1 patient who had undergone right colectomy at the same time, 39 patients were classified according to distance of the GIST from the EGJ in the Near group (0-2.0 cm; n = 16) and the Far group (2.1-5.0 cm; n = 23). RESULTS: We found no marked differences in the operation time, blood loss, length of postoperative hospital stay, or postoperative complication rate in the two groups. Anastomotic leakage occurred with a tumor located on the EGJ. Three tumors recurred in the Near group, and all of them were located on the EGJ. CONCLUSION: Except for GISTs located on the EGJ, laparoscopic local resection for GISTs near the EGJ can be performed safely with few postoperative complications and a low risk of recurrence.Mar. 2022, Surgery today, 52(3) (3), 395 - 400, English, Domestic magazineScientific journal
- BACKGROUND: This study aimed to identify prognostic factors for adenocarcinoma of the esophagogastric junction (AEG) in Siewert type II and characterize the population whose prognosis is expected to improve. PATIENTS AND METHODS: We retrospectively reviewed a database of 68 AEG type II patients who had undergone surgical curative resection without preoperative treatment. RESULTS: Although patients with pathological N0 (pN0) showed favorable 3-year disease-free survival (91%), patients with pN1-3 had poor outcomes (42%, 23%, and 10%). Multivariate analyses showed that the only independent prognostic factor was lymph node metastasis, and that tumor depth (cT3-4) and tumor size (≥4 cm) were correlated closely with lymph node metastasis. CONCLUSION: Surgical curative resection without preoperative treatment is insufficient to treat AEG type II with lymph node metastasis. Among AEG patients, those with the high-risk factors of preoperative tumor depth (T3-4) or/and size (≥4 cm) might need intensive multimodal treatment, including perioperative adjuvant chemotherapy.Feb. 2022, Anticancer research, 42(2) (2), 1051 - 1057, English, International magazineScientific journal
- Jan. 2022, Annals of surgical oncology, English, International magazineScientific journal
- BACKGROUND/AIM: The safety of gastrectomy for patients receiving antithrombotic agents remains unclear. This retrospective cohort study sought to compare outcomes between patients who did and did not receive antithrombotic agents. PATIENTS AND METHODS: This single-center retrospective cohort study included 548 patients who underwent gastrectomy for primary gastric adenocarcinoma from January 2011 to December 2019. The surgical outcomes were compared between two groups according to whether they received antithrombotic therapy (n=121) or not (n=427). RESULTS: Among the entire cohort, the patients in the antithrombotic therapy group were significantly older than those who did not receive this therapy and had significantly higher postoperative complication rates than those who did not (33.1% vs. 23.9%; p=0.046). However, after propensity score matching, no significant difference in the postoperative complication rate was observed between the two groups. CONCLUSION: Despite having a high risk for postoperative complications, patients receiving antithrombotic therapy can safely undergo gastric resection.2022, Cancer diagnosis & prognosis, 2(2) (2), 210 - 215, English, International magazineScientific journal
- BACKGROUND: One of the primary treatment for resectable advanced esophageal squamous cell cancer (ESCC) is neoadjuvant chemotherapy (NAC) followed by minimally invasive esophagectomy (MIE). Because the neutrophil-to-lymphocyte ratio (NLR) is a widely reported prognostic factor in several cancers, we investigated whether the preoperative NLR is a biomarker in ESCC patients treated with NAC and MIE. METHODS: In this study, we investigated 174 ESCC patients who underwent MIE from January 2010 to December 2015, including 121 patients who received NAC. The cutoff value of the NLR was analyzed using the receiver operating characteristic curve. Multivariate analyses were performed to clarify independent prognostic factors for overall survival (OS). RESULTS: The cutoff value of the NLR for OS in 121 patients who received NAC was 2.5 ng/ml, and the area under the curve was 0.63026 (p = 0.0127). The 5-year OS rate was 64% in those with an NLR <2.5 and 39% in those with an NLR ≥2.5. According to multivariate analysis, NLR ≥2.5, pathological T, pathological N, and intraoperative blood loss of >415 ml were independent poor prognostic factors. CONCLUSIONS: NLR is a biomarker of prognosis in ESCC patients who undergo MIE after NAC.Dec. 2021, Journal of surgical oncology, 124(7) (7), 1022 - 1030, English, International magazineScientific journal
- Springer Science and Business Media Deutschland GmbH, Nov. 2021, Annals of Surgical Oncology, 28(12) (12), 7249 - 7257, EnglishScientific journal
- Nov. 2021, Annals of surgical oncology, 28(12) (12), 7258 - 7258, English, International magazineScientific journal
- BACKGROUND: Esophagectomy with lymphadenectomy is the principal treatment for localized esophageal cancer. Conventional minimally invasive esophagectomy (C-MIE) in prone position has spread worldwide as it is less invasive. However, its efficacy remains controversial. Robot-assisted MIE (RAMIE) can have more advantages than C-MIE. Therefore, the current study aimed to validate whether RAMIE is associated with lower incidence of left recurrent laryngeal nerve (RLN) palsy compared with C-MIE in prone position. PATIENTS AND METHODS: In total, 404 patients with esophageal carcinoma underwent MIE (353 C-MIEs and 51 RAMIEs) in prone position at Kobe University between 2010 and 2020. Then, propensity score matching was performed, and results showed that 51 patients should be included in each group. Thereafter, the perioperative outcomes between the two groups were compared. RESULTS: The RAMIE group had a significantly longer operative time than the C-MIE group (P < 0.0001). However, the number of lymph nodes resected along the left RLN was similar in both groups. Moreover, the incidence of left RLN palsy was significantly lower in the RAMIE group than in the C-MIE [Clavien-Dindo classification grade II; 0 (0%) versus 32 (9%), P = 0.022 in entire cohort, and 0 (0%) versus 5 (10%), P = 0.022 in matched cohort. Esophagectomy Complications Consensus Group definitions type I; 8 (16%) versus 101 (29%), P = 0.041 in entire cohort and 8 (16%) versus 18 (35%) in matched cohort, P = 0.023]. CONCLUSION: RAMIE is superior to C-MIE in prone position in decreasing the incidence of left RLN palsy.Nov. 2021, Annals of surgical oncology, 28(12) (12), 7249 - 7257, English, International magazineScientific journal
- BACKGROUND: Lateral pelvic lymph node metastasis impairs the oncological outcomes of patients with rectal cancer. Although lateral pelvic lymph node dissection (LLND) might be an effective procedure for such patients, the associated risk factors for postoperative complications are unknown. PATIENTS AND METHODS: The operative outcomes of 21 patients undergoing unilateral LLND and 26 patients undergoing bilateral LLND for rectal cancer were compared. The risk factors for complications were evaluated using a logistic regression model. RESULTS: Univariate and multivariate analyses revealed that a longer operative time (≥480 min) was the most important risk factor for grade II or more postoperative complications according to the Clavien-Dindo classification (odds ratio=6.58; 95% confidence interval=1.35-32.1; p=0.020). A bilateral procedure was not a significant risk factor for postoperative complications. CONCLUSION: Surgeons should make efforts to shorten the operative time to reduce the risk of postoperative complications.Nov. 2021, Anticancer research, 41(11) (11), 5599 - 5604, English, International magazineScientific journal
- A 73-year-old man with mixed-type intraductal papillary mucinous neoplasm of the pancreas body was followed up for 14 years. Based on imaging findings, the intraductal papillary mucinous neoplasm of the pancreas met the high-risk stigmata, and new hepatic masses were suspected to be intraductal papillary neoplasms of the bile duct. With a diagnosis of intraductal papillary mucinous neoplasm of the pancreas and intraductal papillary neoplasm of the bile duct, the patient had undergone left lateral hepatectomy and distal pancreatectomy. Based on pathology, the pancreatic specimen was diagnosed as a high-grade intraductal papillary mucinous neoplasm of the pancreas, and the hepatic specimen was diagnosed as an intraductal papillary neoplasm of the bile duct and hepatocellular carcinoma. The intraductal papillary neoplasms of the bile duct and hepatocellular carcinoma were adjacent to each other. Fifteen months after surgery, recurrence in the remnant pancreas was detected. The patient had undergone residual total pancreatectomy, with no recurrence thirty months after the second resection. This case demonstrates that second surgery for metachronous high-risk lesions in the remnant pancreas of patients with intraductal papillary mucinous neoplasm of the pancreas and intraductal papillary neoplasm of the bile duct may also be considered to improve survival.Oct. 2021, Clinical journal of gastroenterology, 14(5) (5), 1536 - 1543, English, Domestic magazineScientific journal
- PURPOSE: Subtotal gastrectomy (SG) has become a general option for distal gastric cancer. However, the availability of an organ-preserving approach for the treatment of remnant gastric cancer (RGC) is still controversial. Thus, the objective of the present study was to assess the safety and efficacy of SG for RGC by integrating data from published articles. METHODS: We searched the PubMed, Cochrane Library, and Web of Science databases for studies that compared SG versus total gastrectomy (TG) for RGC published from the inception of the databases until May 2020. A meta-analysis was performed using the Review Manager Version 5.0 software program from the Cochrane Collaboration. RESULTS: Three retrospective cohort studies with 144 patients were included. The meta-analysis revealed that the operative time of the SG group was significantly shorter than that in the TG group (MD: -34.84. 95% CI: -59.97- -9.71, P = 0.007). There was no significant difference in intraoperative blood loss (MD: -109.19. 95% CI: -240.37-21.99, P =0.10), length of postoperative hospital stay (MD: 0.40. 95% CI: -3.03-3.83, P = 0.82), postoperative complications (RR: 1.41. 95% CI: 0.76-2.63, P = 0.28), or recurrence (RR: 2.33, 95% CI: 0.48-11.44, P = 0.30). SG for RGC tended to be correlated with favorable 5-year overall survival; however, the association was not statistically significant (HR: 0.89, 95% CI: 0.63-1.26, P = 0.51). CONCLUSION: Organ-preserving approaches such as SG may be a safe and feasible treatment option for early-stage RGC.Aug. 2021, Langenbeck's archives of surgery, 406(5) (5), 1379 - 1385, English, International magazineScientific journal
- (一社)日本消化器外科学会, Jul. 2021, 日本消化器外科学会総会, 76回, RS23 - 3, Japanese残胃癌に対する治療戦略 残胃癌における胃亜全摘の有効性・安全性評価のための系統的レビュー研究
- (一社)日本膵臓学会, Apr. 2021, 膵臓, 36(2) (2), 163 - 168, Japanese
- We should know that hepatocellular carcinoma can progress as if it replaces the bile duct wall itself.Mar. 2021, Clinical case reports, 9(3) (3), 1561 - 1565, English, International magazine
- In the original article, there are errors in Fig. 1. Following is the corrected figure.Dec. 2020, Annals of surgical oncology, 27(Suppl 3) (Suppl 3), 970 - 971, English, International magazine
- PURPOSE: Esophagectomy with extended lymphadenectomy remains the mainstay of treatment for localized esophageal squamous cell carcinoma (ESCC). Thoracic duct (TD) resection has been recommended as part of extended lymphadenectomy, although its merits are unclear. The aim of this two-institutional, matched-cohort study is to clarify whether TD resection improves prognosis in esophagectomy for ESCC. PATIENTS AND METHODS: In this two-institutional, matched-cohort study of 399 patients with ESCC who underwent McKeown esophagectomy between 2010 and 2014, the primary outcomes were overall survival (OS), disease-free survival (DFS), and cause-specific survival (CSS). Secondary outcomes were perioperative results and recurrence patterns. RESULTS: Based on a propensity score, 122 TD-resected or 122 TD-preserved patients in all stages were selected (median follow-up 4.5 years). The 5-year OS, DFS, and CSS rates in the TD-resected versus TD-preserved groups were 49% versus 60%, 53% versus 57%, and 58% versus 70%, respectively, without any significant differences. Operative time for the thoracic procedure was significantly longer and the number of retrieved mediastinal nodes was significantly higher in the TD-resected group (P = 0.009 and 0.005, respectively). The rates of chylothorax and left recurrent laryngeal nerve (RLN) palsy were significantly higher in the TD-resected group (P = 0.041 and 0.018, respectively). There were no significant differences in rates of local or distant metastases between the two groups. CONCLUSIONS: TD resection does not contribute to improve OS, DFS, or CSS in ESCC but increases incidence of chylothorax and left RLN palsy. Prophylactic TD resection should be avoided in esophagectomy for ESCC.Nov. 2019, Annals of surgical oncology, 26(12) (12), 4053 - 4061, English, International magazineScientific journal
- PURPOSE: Completion gastrectomy (CG) is a common procedure for remnant gastric cancer (RGC). However, partial gastrectomy for gastric cancer has several benefits compared to total gastrectomy in terms of the quality of life. In this study, we evaluated the feasibility and advantage of subtotal resection of the remnant stomach (SR) for clinical stage IA RGC. METHODS: A total of 43 patients who underwent gastrectomy for clinical stage IA RGC were included. CG and SR were performed on 27 (62.8%) and 16 patients (37.2%), respectively. The short- and long-term outcomes, including the nutritional status, after CG and SR for clinical stage IA RGC were compared between the two groups. RESULTS: There were no significant differences in pathological stage or incidence of postoperative complications between the two groups. The decrease in body weight, body mass index, and serum albumin level was significantly lower in the SR group than in the CG group (P < 0.001, P = 0.025, and 0.008). In the SR group, there was no recurrence at the remaining lymph nodes or gastric stump. The 5-year overall survival rate was 87.8% in the CG group and 86.1% in the SR group, without a significant difference between the two groups (P = 0.959). CONCLUSIONS: The present study showed the noninferiority of SR to CG based on surgical and oncological outcomes for clinical stage IA RGC. Furthermore, SR has an advantage over CG in terms of postoperative nutritional status. Therefore, SR could be an alternative elective treatment option for early RGC located around the anastomotic site.Lead, Sep. 2019, Langenbeck's archives of surgery, 404(6) (6), 753 - 760, English, International magazineScientific journal
- We report a case of laparoscopic anatomical segment 3 segmentectomy for hepatocellular carcinoma (HCC) accompanied by hypoplasia of the right hepatic lobe. An 80-year-old man was admitted with a suspicion of HCC diagnosed by computed tomography during follow-up for thyroid cancer. Dynamic computed tomography showed 40-mm HCC in segment 3 and hypoplasia of the right hepatic lobe with the Chilaiditi sign. We performed laparoscopic anatomical segment 3 segmentectomy. There were no postoperative complications, and the patient was discharged 6 days postoperatively. This procedure can be performed safely and is technically feasible, but special attention should be paid to anatomical alterations to avoid fatal surgical complications.Jul. 2019, Journal of surgical case reports, 2019(7) (7), rjz213, English, International magazine
- INTRODUCTION: Lung large-cell neuroendocrine carcinoma (LCNEC) is an aggressive and a rare type of lung cancer, and the prognosis of LCNEC with distant metastasis is extremely poor, with a five-year survival rate of 0%. Here, we report a case of laparoscopic hepatectomy for liver metastasis of lung LCNEC. PRESENTATION OF CASE: A 63-year-old man received a routine physical examination, and abnormal chest radiographic findings were observed; chest computed tomography (CT) in our hospital revealed that the patient had left pneumothorax and a lesion measuring 18 mm in the inferior lingular segment of the lung. The patient underwent thoracoscopic lobectomy, and the final pathological diagnosis was lung LCNEC. Four years after surgery, abdominal CT revealed a mass measuring 27 mm in the liver. The patient underwent laparoscopic partial hepatectomy, and postoperative pathological examination showed liver metastasis of LCNEC. There was no sign of recurrence 6 months after hepatectomy. DISCUSSION: LCNEC with distant metastasis has a poor response to systemic chemotherapy, and the median survival time of patients with distant metastasis is estimated to be approximately 6 months, with a five-year survival rate of 0%. Although the common site of metastasis from LCNEC is the liver, there are no previous reports of hepatectomy for liver metastasis of LCNEC. CONCLUSION: We report a case of laparoscopic hepatectomy for liver metastasis of lung LCNEC. It is suggested that surgical resection for solitary distant metastasis of LCNEC may improve prognosis.2019, International journal of surgery case reports, 65, 40 - 43, English, International magazineScientific journal
- BACKGROUND: Body mass index (BMI) is commonly used to classify obesity. However, BMI does not always reflect the degree of visceral fat. This study aimed to clarify the usefulness of measuring the depth from the skin to the celiac artery using computed tomography, as a simple predictive index for longer operation time during laparoscopic distal gastrectomy (LDG). METHODS: From September 2012 to March 2016, 66 patients who underwent LDG with D1+ lymph node dissection were included. The depth from the skin to the bifurcation of the celiac artery was defined as 'skin-to-celiac artery distance (SCD).' The patients were divided into two groups based on the median operation time. [Time scenarios from omentum incision to specimen extirpation and infrapyloric and suprapancreatic lymph node dissections (I-LND, S-LND) were assessed.] The factors eliciting a longer operation time than the median operation time were investigated. RESULTS: From omentum incision to specimen extirpation, BMI, thickness of subcutaneous fat (TSF), and SCD (P = 0.002, P = 0.039, P < 0.001) were the factors associated with longer operation time. Furthermore, BMI, TSF, and SCD in I-LND (P = 0.008, P = 0.022, P < 0.001) and BMI and SCD in S-LND (P < 0.001, P < 0.001) were associated with longer operation time. The multivariate analysis showed that a long SCD was the only significant independent factor to predict an operation time longer than the median operation time (P = 0.001). The best cutoff level of SCD calculated using the receiver operating characteristic curve was 88 mm. CONCLUSIONS: This study demonstrated that SCD is a simple predictive index for longer operation time during LDG.Lead, Apr. 2018, World journal of surgery, 42(4) (4), 1065 - 1072, English, International magazineScientific journal
- (株)へるす出版, Jan. 2017, 消化器外科, 40(1) (1), 41 - 55, Japanese【胃癌・食道癌のリンパ節郭清のすべて】食道癌に対する中下縦隔リンパ節郭清
- We report a case of successful laparoscopic distal gastrectomy with D2 lymph node dissection preserving the common hepatic artery branched from the left gastric artery for advanced gastric cancer with an Adachi type VI (group 26) vascular anomaly. A 76-year-old female patient was admitted with a diagnosis of advanced gastric cancer at the anterior wall to the lesser curvature of the antrum (cT3N0M0 cStage IIA). Dynamic computed tomography showed the ectopia of the common hepatic artery branched from the left gastric artery. We made a diagnosis of an Adachi type VI (group 26) vascular anomaly and performed the abovementioned operation. In this anomaly pattern, scrupulous attention is required to remove the suprapancreatic lymph nodes because the portal vein is located immediately dorsal to those lymph nodes and is at increased risk for the injury in this situation. The common hepatic artery is branched from the left gastric artery, and the hepatic perfusion from the superior mesenteric artery is not present in group 26. Planning to preserve the artery will improve safety when it is possible oncologically. There were no postoperative complications, and the patient was discharged 9 days after the operation. To our knowledge, the present case is the first reported case of a laparoscopic distal gastrectomy with D2 lymph node dissection with an Adachi type VI (group 26) vascular anomaly. Preoperative diagnostic imaging is very important to prevent surgical complications because the reliable identification of vascular anomaly during an operation is very difficult.Lead, Dec. 2016, Surgical case reports, 2(1) (1), 55 - 55, English, International magazineScientific journal
- INTRODUCTION: Laparoscopic distal gastrectomy (LDG) with D1+ lymph node dissection (LND) for early gastric cancer has been widely accepted. However, LDG with D2 LND for advanced gastric cancer remains in limited use. The aim of this retrospective study was to clarify the safety of LDG with D2 LND for gastric cancer. METHODS: From January 2010 to September 2014, 296 patients underwent LDG; those who received D1+ LND (n = 230) or D2 LND (n = 66) were included in this study. The clinicopathological characteristics and short-term outcomes of both groups were investigated and compared. RESULTS: There were no significant differences in the incidence of postoperative complications between the two groups. However, the frequency of infectious intra-abdominal complications was higher in the D2 LND group than in the D1+ LND group. Additionally, a lower risk of infectious intra-abdominal complications was seen with certified than with uncertified operators. CONCLUSION: The evaluation of short-term outcomes demonstrated that LDG with D2 LND is generally feasible. However, the risk of infectious intra-abdominal complications is higher with D2 LND than with D1+ LND. Also, D2 LND should be performed by trained operators.Lead, May 2016, Asian journal of endoscopic surgery, 9(2) (2), 116 - 21, English, Domestic magazineScientific journal
- BACKGROUND: In esophageal cancer, lymph nodes along the recurrent laryngeal nerves (RLNs) are thought to be highly involved. Complete dissection of these lymph nodes is recommended but there is limited working space in the left upper mediastinum and advanced dissection skills are required. We present herein a new method for lymphadenectomy along the left RLN, called the Bascule method during prone esophagectomy. METHODS: The fundamental concept of this new method is to draw the proximal portion of the divided esophagus and tissue that includes the left RLN and lymph nodes through a gap between the vertebral body and the right scapula. Using this technique, a two-dimensional membrane, similar to the "esophageal mesenteriolum" (lateral pedicle), will be easily recognizable. Identification and reliable cutting of the tracheoesophageal artery and distinguishing the left RLN from the lymph nodes should be easy. This technique was evaluated in 39 consecutive cases of prone esophagectomy for squamous cell cancer. RESULTS: There were 18 patients who underwent the new method (Bascule method; Bm) and 21 patients who underwent the conventional method (Cm). The duration of the thoracic procedure and dissection along the left RLN was significantly shorter in Bm group than in Cm group (258 ± 30 vs. 291 ± 39 min; p = 0.007 and 66 ± 9 vs. 75 ± 14 min; p = 0.036, respectively). Estimated blood loss in Bm group was 20 ± 11 g compared to 38 ± 32 g in Cm group (p = 0.028). No intraoperative morbidity related to the left RLN was observed in either group. The hoarseness rate in Bm group was 28 %, which was lower than that in the Cm group (48 %). CONCLUSIONS: The Bascule method for lymphadenectomy along the left RLN during prone esophagectomy is technically safe and feasible and reduces operative time and blood loss.Aug. 2015, Surgical endoscopy, 29(8) (8), 2442 - 50, English, International magazineScientific journal
- (株)癌と化学療法社, May 2015, 癌と化学療法, 42(5) (5), 633 - 635, Japanese[Refereed]
- [A case of stage IV b pancreatic head cancer that was resected because of a good response to chemotherapy].The prognosis of Stage IV b pancreatic cancer is extremely poor; the mean survival time is 2-4 months. However, new anticancer agents can improve the outcome of advanced pancreatic cancer. We present the case of a 50-year-old female patient with Stage IV b pancreatic head cancer with invasion to the superior mesenteric vein(SMV)and multiple liver metastases. The patient received S-1 as first-line chemotherapy. Three months later, a further CT scan showed reduction of the pancreatic tumor, disappearance of the liver metastases, and reduction in SMV invasion. Therefore, a subtotal stomach-preserving pancreatoduodenectomy with partial SMV resection was performed. Following surgery, the patient received S-1 chemotherapy again. However, lung metastasis appeared. Despite the initiation of gemcitabine(GEM)treatment, the patient developed metastases in other parts of the lung and the abdominal wall. She died 46 months after surgery, but it is noteworthy that the liver metastases were manageable. The combination of chemotherapy and surgery was effective in prolonging survival in this patient with Stage IV b pancreatic head cancer.May 2015, Gan to kagaku ryoho. Cancer & chemotherapy, 42(5) (5), 633 - 5, Japanese, Domestic magazineScientific journal
- 第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同手術における結腸間膜尾側からのアプローチの有用性の検討Public symposium
- 第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference切除困難な胃GISTに対する術前イマチニブによる補助療法の有用性に関する検討Public symposium
- 第96回日本胃癌学会総会, English, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conferenceThe significance of conversion surgery following chemotherapy for clinical stage IV gastric cancerOral presentation
- 第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference当院における進行胃癌に対するロボット支援下胃切除術の工夫Oral presentation
- 第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference食道胃接合部腺癌に対する腹腔鏡下経裂孔的再建における左横隔膜開放法の有用性Public symposium
- 第56回制癌剤適応研究会, Japanese, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, Japan, Domestic conference術前化学療法を施行した食道癌における腫瘍マーカーと生存転帰の検討Oral presentation
- 第56回制癌剤適応研究会, Japanese, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, Japan, Domestic conference切除不能進行胃癌に対する conversion surgery の周術期化学療法の重要性及び治療成績Public symposium
- 第56回制癌剤適応研究会, Japanese, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, Japan, Domestic conference鼠径リンパ節転移を伴う直腸・肛門管腺癌の術後成績；術前治療と選択的鼠径リンパ節郭清・直腸間膜全切除による治療戦略Oral presentation
- The 19th Annual Academic Surgical Congress, English, Annual Academic Surgical Congress, Washington, D.C., United States, International conferenceClinical Significance of SUVmax on FDG-PET in Patients with Rectal Cancer Undergoing NACRTOral presentation
- 第207回近畿外科学会, Japanese, 関西医科大学 外科学講座, 枚方市, Japan, Domestic conference高齢の胃癌患者に対する術前化学療法の安全性についての検討Oral presentation
- 第207回近畿外科学会, Japanese, 関西医科大学 外科学講座, 枚方市, Japan, Domestic conferenceリンパ節郭清個数からみる MIE における上縦隔リンパ節郭清の重要性Oral presentation
- 日本消化器病学会近畿支部第120回例会, Japanese, 神戸大学大学院医学研究科外科学講座 肝胆膵外科学分野, 神戸, Japan, Domestic conference当院におけるTaTME併用大腸全摘術の手術成績Public symposium
- 食道癌治療フォーラム, Japanese, MSD株式会社, Web, Japan, Domestic conference食道癌に対する手術と周術期治療Oral presentation
- 第194回兵庫県外科医会学術集会, Japanese, 兵庫県外科医会, 神戸, Japan, Domestic conference十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同手術における結腸間膜尾側からの腹腔鏡アプローチの有用性の検討Oral presentation
- 第36回日本バイオセラピィ学会学術集会総会, Japanese, 昭和大学医学部内科学講座腫瘍内科学部門, 東京, Japan, Domestic conference深層学習アルゴリズムに基づくイメージングサイトメトリーを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索Oral presentation
- 第36回日本バイオセラピィ学会学術集会総会, Japanese, 昭和大学医学部内科学講座腫瘍内科学部門, 東京, Japan, Domestic conference大腸癌腫瘍免疫微小環境における CD4＋T 細胞に与える肥満の影響Oral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference安全な Collard 変法吻合を目指した変革と短期成績Oral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference下部進行直腸癌に対する TaTME 併用の有用性とラーニングカーブに関する検討Oral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conferenceロボット支援食道切除における上縦隔リンパ節郭清手技と短期成績Oral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conferenceロボット支援胃切除術におけるリンパ節郭清時間の learning curveOral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference多発リンパ節転移を伴う進行食道癌に対する Minimally invasive esophagectomyOral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference経肛門アプローチ併用による２チーム側方郭清の手術手技と手術成績Public symposium
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference人間工学に基づく「鏡視下クロソイド・カーブ針」の開発Oral presentation
- 第44回日本肥満学会・第41回日本肥満症治療学会学術集会, Japanese, 東北大学大学院医学系研究科 糖尿病代謝内科学分野・岩手医科大学医学部内科学講座 糖尿病・代謝・内分泌内科分野, 仙台, Japan, Domestic conference当院における腹腔鏡下スリーブ状胃切除術の短期治療成績の検討Poster presentation
- 第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, Japan, Domestic conference深層学習アルゴリズムに基づくイメージングサイトメトリーを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索Public symposium
- 第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, Japan, Domestic conference脂肪細胞によるがん幹細胞性制御機構Poster presentation
- 第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, Japan, Domestic conference大腸癌手術前後における腸内細菌と代謝物の変化についての検討Public symposium
- 第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, Japan, Domestic conference放射線治療において抗腫瘍効果に寄与する腫瘍内CD8+T細胞の動態Public symposium
- 第74回日本気管食道科学会総会ならびに学術講演会, Japanese, 独立行政法人国立病院機構 九州がんセンター 消化管外科, 福岡, Japan, Domestic conference高齢者に対する食道切除後の腸瘻チューブ留置による栄養介入の重要性Oral presentation
- 第74回日本気管食道科学会総会ならびに学術講演会, Japanese, 独立行政法人国立病院機構 九州がんセンター 消化管外科, 福岡, Japan, Domestic conferenceリンパ節郭清個数からみるMinimally invasive esophagectomyにおける上縦隔リンパ節郭清の重要性Oral presentation
- 第26回腹腔鏡内視鏡合同手術研究会, Japanese, 神戸大学 食道胃腸外科・神戸大学 国際がん医療・研究センター 消化器内科, 神戸, Japan, Domestic conference十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同⼿術における結腸間膜尾側からの腹腔鏡アプローチの有⽤性の検討Oral presentation
- IASGO-CME Advanced Post-Graduate Course in Kobe 2023, English, Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Graduate School of Medicine, Kobe University, Kobe, Japan, International conferenceClinical Significance of SUVmax on FDG-PET to Predict Treatment Response and Outcomes in Patients with Rectal Cancer Undergoing NACRTPoster presentation
- IASGO-CME Advanced Post-Graduate Course in Kobe 2023, English, Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Graduate School of Medicine, Kobe University, Kobe, Japan, International conferenceThe advantage of geriatric nutritional risk index as a prognostic indicator for elderly patients with early gastric cancer after noncurative endoscopic resectionPoster presentation
- The 3rd International Congress of the Asian Oncology Society (AOS2023), English, Department of Urology, Keio University School of Medicin, Yokohama, Japan, International conferenceThe significance of geriatric nutritional risk index as a prognostic factor for early gastric cancer in elderly patients after non-curative endoscopic resectionOral presentation
- The 3rd International Congress of the Asian Oncology Society (AOS2023), English, Department of Urology, Keio University School of Medicin, Yokohama, Japan, International conferenceAlbumin and derived neutrophil-to-lymphocyte ratio is a novel prognostic factor for patients with esophageal squamous cell carcinomaOral presentation
- The 3rd International Congress of the Asian Oncology Society (AOS2023), English, Department of Urology, Keio University School of Medicin, Yokohama, Japan, International conferenceClinical outcomes of neoadjuvant therapy followed by selective inguinal lymph node dissection and total mesorectal excision for metastasised low rectal cancerOral presentation
- 第61回日本癌治療学会学術集会, Japanese, 慶應義塾大学医学部 泌尿器科学教室, 横浜, Japan, Domestic conference当院における食道癌術前 DCF 療法と術前 CF 療法の後方視的検討Poster presentation
- 第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conference右肺腺癌虫垂転移に対して腹腔鏡下回盲部切除術を施行した１例Oral presentation
- 第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conference腹腔鏡下に切除し得た成人骨盤嚢胞性腫瘤の２例Oral presentation
- 第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conference下部直腸癌に対するTaTMEの有用性とラーニングカーブPublic symposium
- 第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conferenceリンパ節転移比率からみるMinimally invasive esophagectomyにおける上縦隔リンパ節郭清の重要性Public symposium
- 第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conference当院におけるロボット支援下結腸切除術の導入 10例の経験Public symposium
- The Korea International Gastric Cancer Week 2023 (KINGCA WEEK 2023), English, The Korean Gastric Cancer Association, Seoul, Korea, Republic of, International conferenceThe advantage of geriatric nutritional risk index as a prognostic indictor for elderly patients with early gastric cancer after non-curative endoscopic resectionOral presentation
- The Korea International Gastric Cancer Week 2023 (KINGCA WEEK 2023), English, The Korean Gastric Cancer Association, Seoul, Korea, Republic of, International conferenceEfficacy of 18F-fluoro-2-deoxyglucose positron emission tomography as a predictor of treatment response to neoadjuvant chemotherapy for gastric cancerOral presentation
- 第1回Hanshin-GI, Japanese, 大鵬薬品工業株式会社, 大阪/Web, Japan, Domestic conferenceロボット支援下食道切除術の術者育成-アプローチのパラダイムシフトに沿った修練-Invited oral presentation
- 第33回日本サイトメトリー学会学術集会, Japanese, 杏林大学大学院医学研究科 共同研究施設フロ−サイトメトリ−部門, Web, Japan, Domestic conference深層学習に基づくイメージサイトメトリーによる直腸癌の新規予後因子の探索Poster presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference直腸癌の術前化学放射線療法への抵抗性における Wnt/β-catenin シグナル活性化の重要性Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference高齢胃癌患者への内視鏡治療後非治癒切除症例における予後因子の検討Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference当院における TaTME 併用大腸全摘術の手術成績の検討Public symposium
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference術中診断にて漿膜浸潤以上の深達度であった進行胃癌に対する腹腔鏡下胃切除の安全性に関する検討Public symposium
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference当院における進行胃癌に対するロボット支援下胃切除術の短期治療成績の検討Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conferenceASA 分類 Class 3 以上の大腸癌患者に対する腹腔鏡手術と開腹手術の比較検討Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference高齢者食道癌患者に対する胸腔鏡下食道切除術Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference短期・長期成績からみた下部直腸癌に対するTaTME の有用性についてOral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference高齢者に対する胸腔鏡下食道切除後の経腸栄養は sarcopenia を予防できるか?Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference鼠経転移を伴う直腸肛門腺癌に対する術前治療と選択的側方郭清の治療成績Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference十二指腸浸潤を伴う胃癌に対する胃切除術の安全性の検討Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conferenceロボット支援下食道切除術の術者育成Oral presentation
- 第99回大腸癌研究会学術集会, Japanese, 関西労災病院 外科, 尼崎, Japan, Domestic conference下部直腸癌に対するTaTMEの有用性とラーニングカーブOral presentation
- 第77回日本食道学会学術集会, Japanese, 近畿大学医学部 外科学教室上部消化管部門, 大阪, Japan, Domestic conference高齢者に対する腹臥位胸腔鏡下食道切除術Poster presentation
- 第77回日本食道学会学術集会, Japanese, 近畿大学医学部 外科学教室上部消化管部門, 大阪, Japan, Domestic conference全周性かつ表層拡大食道癌症例の特徴と手術治療成績Poster presentation
- 第77回日本食道学会学術集会, Japanese, 近畿大学医学部 外科学教室上部消化管部門, 大阪, Japan, Domestic conference食道胃接合部癌に対する腹腔鏡下経裂孔的再建における左横隔膜開放法の有用性Public symposium
- 第77回日本食道学会学術集会, Japanese, 近畿大学医学部 外科学教室上部消化管部門, 大阪, Japan, Domestic conference短期・長期成績からみたロボット支援食道切除術のエビデンスPublic symposium
- 第11回若手消化器外科腹腔鏡セミナー, Japanese, 神戸大学大学院医学研究科外科学講座 食道胃腸外科学分野・肝胆膵外科学分野, 神戸, Japan, Domestic conference基調講演2 内視鏡外科における手術の予習と復習Others
- 第11回若手消化器外科腹腔鏡セミナー, Japanese, 神戸大学大学院医学研究科外科学講座 食道胃腸外科学分野・肝胆膵外科学分野, 神戸, Japan, Domestic conference概要Others
- 第44回癌免疫外科研究会, Japanese, 千葉大学大学院医学研究院 先端応用外科, 千葉, Japan, Domestic conference大腸癌腫瘍免疫微小環境におけるCD4＋T細胞に与える肥満の影響Oral presentation
- 第44回癌免疫外科研究会, Japanese, 千葉大学大学院医学研究院 先端応用外科, 千葉, Japan, Domestic conference化学放射線治療による腫瘍微小環境の変化～深層学習に基づくイメージサイトメトリーを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索～Oral presentation
- The 15th International Gastric Cancer Congress (IGCC 2023), English, Department of Surgery, Keio University School of Medicine, Yokohama, Japan, Domestic conferenceNeutrophil lymphocyte ratio and histological response correlate with prognosis of gastric cancer undergoing neoadjuvant chemotherapyOral presentation
- The 15th International Gastric Cancer Congress (IGCC 2023), English, Department of Surgery, Keio University School of Medicine, Yokohama, Japan, Domestic conferenceSafety of laparoscopic gastrectomy for advanced gastric cancer with greater than serosal invasion depthOral presentation
- The 15th International Gastric Cancer Congress (IGCC 2023), English, Department of Surgery, Keio University School of Medicine, Yokohama, Japan, Domestic conferenceThe prognostic factors of early gastric cancer in elderly patients after non-curative endoscopic resectionOral presentation
- 第193回兵庫県外科医会学術集会, Japanese, 兵庫県外科医会, 神戸, Japan, Domestic conference難治性食道狭窄に対する腹腔鏡下食道バイパス術の工夫点と成績Oral presentation
- 第66回関西胸部外科学会学術集会, Japanese, JCHO大阪病院, 大阪, Japan, Domestic conference高齢者食道癌患者に対する胸腔鏡下食道切除術Public symposium
- 第66回関西胸部外科学会学術集会, Japanese, JCHO大阪病院, 大阪, Japan, Domestic conference進行食道癌に対するロボット支援下食道切除Public symposium
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference食道切除 ・ 胸骨後再建後胃管切除に対する仰臥位胸腔鏡アプローチPoster presentation
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conferenceThe mGPS is a significant oncological marker of rectal cancer patients undergoing NACRT.Oral presentation
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference切除不能進行胃癌に対する姑息的胃切除術の安全性に関する検討Oral presentation
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference大量の難治性乳び腹水を伴う直腸間膜リンパ管嚢腫破裂に対して手術加療を施行した 1 例Others
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference当院における TaTME 併用による大腸全摘術、 回腸嚢肛門吻合術の手術成績Public symposium
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference高齢胃癌患者の内視鏡治療後非治癒切除症例における予後因子の検討Public symposium
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference血行再建を伴う胸壁前有茎空腸再建術の有用性Public symposium
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference膵臓側に位置する表在性非乳頭部十二指腸腫瘍に対する腹腔鏡内視鏡合同手術の工夫Public symposium
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference自律神経を意識した腹臥位胸腔鏡下食道切除術Public symposium
- The 18th Annual Academic Surgical Congress, English, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, Washington, DC, United States, Domestic conferenceThe mGPS is a significant oncological marker of rectal cancer patients undergoing NACRTOral presentation
- The 18th Annual Academic Surgical Congress, English, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, Washington, DC, United States, Domestic conferenceRisk factor for stricture after cervical triangular anastomosis in Minimally Invasive EsophagectomyOthers
- 第45回日本癌局所療法研究会, Japanese, 順天堂大学医学部・消化器外科学講座下部消化管外科, 東京, Japan, Domestic conference鼠径部転移を伴う直腸肛門腺癌に対する術前治療と選択的側方郭清の治療成績Oral presentation
- 第45回日本癌局所療法研究会, Japanese, 順天堂大学医学部・消化器外科学講座下部消化管外科, 東京, Japan, Domestic conference直腸癌の術前化学放射線療法への抵抗性における Wnt/ β -catenin シグナル活性化の重要性Oral presentation
- 第21回日本ヘルニア学会学術集会, Japanese, 大阪府済生会吹田病院へルニアセンター, 大阪, Japan, Domestic conference当科における全身合併症を伴う鼠径部ヘルニア手術の周術期管理の安全性の検討Public symposium
- 第77回手術手技研究会, Japanese, 愛知医科大学 消化器外科, 名古屋, Japan, Domestic conference難治性食道狭窄に対する腹腔鏡下食道バイパス術の工夫点と成績Public symposium
- 第77回手術手技研究会, Japanese, 愛知医科大学 消化器外科, 名古屋, Japan, Domestic conference当院における経肛門的アプローチ併用による大腸全摘出の手術手技Public symposium
- 第77回手術手技研究会, Japanese, 愛知医科大学 消化器外科, 名古屋, Japan, Domestic conference当院におけるロボット支援下胃切除術のメインデバイスの変遷Public symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conferenceオープンソースの物体検出アルゴリズム YOLOv3 を用いた胸腔鏡下食道亜全摘術の手術動画解析Public symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference下部進行直腸癌に対する術前化学放射線療法と選択的側方郭清の治療成績Poster presentation
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference食道切除後長期の腸瘻での栄養管理はサルコペニアを予防するPublic symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conferenceAI 病理診断システムを用いた直腸癌の新規予後因子の探索Public symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference局所進行直腸癌術前療法における腫瘍内レジデントメモリー CD8+T 細胞の動態とその役割Public symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conferenceDiversity からさらに未来へ～Diversity だけで十分ですか？ ～Others
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference経肛門アプローチによる側方郭清の標準化手術手技と手術成績Public symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference食道胃接合部癌に対する経裂孔的腹腔鏡下 y 字型食道胃管吻合の有用性Public symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference当院における胃・食道胃接合部腺癌に対する術前化学療法の治療成績の検討Public symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conferencecStageIV 胃癌の conversion surgery における周術期化学療法の検討Public symposium
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科, 札幌, Japan, Domestic conference切除不能進行胃癌に対する姑息的胃切除術の安全性に関する検討Public symposium
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科, 札幌, Japan, Domestic conference高齢の胃癌患者に対する術前化学療法の安全性の検討Poster presentation
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科, 札幌, Japan, Domestic conference当院におけるCY1を伴う進行胃癌に対する集学的治療戦略Poster presentation
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科, 札幌, Japan, Domestic conference胃癌切除例におけるpoorly cohesive carcinomaの臨床病理学的特徴と予後に関する検討Public symposium
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科, 札幌, Japan, Domestic conference新規半消化態栄養剤を用いた胃癌術後経口栄養療法の安全性に関する検討Poster presentation
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科, 札幌, Japan, Domestic conference腹腔鏡下経裂孔アプローチにおける左横隔膜開放法による下縦隔郭清・再建の安全性に関する検討Poster presentation
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科, 札幌, Japan, Domestic conferenceデジタルポスター 104 症例報告 9Others
- 第55回制癌剤適応研究会, Japanese, 横浜市立大学 消化器・腫瘍外科学, 鎌倉, Japan, Domestic conferenceStageIV胃癌のconversion surgeryにおける周術期化学療法と予後の検討Public symposium
- 第19回日本消化管学会総会学術集会, Japanese, 日本医科大学消化器内科学・日本医科大学付属病院消化器・肝臓内科, 東京, Japan, Domestic conference胃癌・食道胃接合部癌の術前化学療法効果診断における組織学的効果判定および宿主免疫指標マーカーの有用性の検討Public symposium
- 第98回大腸癌研究会学術集会, Japanese, 順天堂大学大学院医学研究科・人体病理病態学, 東京, Japan, Domestic conference当院における若年者大腸癌手術症例の検討Poster presentation
- Asian-Pacific Congress of Robotic Laparoscopic Surgery 2022 (ACRLS2022), English, Fujita Health University Hospital International Medical Center, Nagoya/web, Japan, Domestic conferenceNovel “Modified Bascule method” for lymphadenectomy along the left recurrent laryngeal nerve during robot-assisted minimally invasive esophagectomyOral presentation
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conference難治性食道狭窄に対する腹腔鏡下食道バイパス術の工夫点と成績Oral presentation
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conference食道癌に対する腹臥位胸腔鏡下食道切除術の短期・長期成績Oral presentation
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conference腫瘍深達度が漿膜浸潤以上の進行胃癌に対する腹腔鏡下胃切除の安全性に関する検討Oral presentation
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conference直腸癌に対する Abdominal robotic approach 併用による Hybrid TaTMEOral presentation
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conferenceTransanal アプローチ併用側方郭清の治療成績と安全に行うための工夫Oral presentation
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conference当科における残胃癌に対する腹腔鏡下残胃全摘術の手術成績と予後の検討Public symposium
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conferenceロボット支援食道切除の短期成績 - 胸腔鏡手術との比較 -Public symposium
- 第26回日本バイオ治療法学会学術集会, Japanese, 徳島大学大学院社会産業理工学研究部生物資源産業学域, 大阪, Japan, Domestic conferenceAI 病理診断システムを用いた直腸癌の新規予後因子の探索Oral presentation
- 第43回日本肥満学会・第40回日本肥満症治療学会学術集会, Japanese, 琉球大学大学院 医学研究科 内分泌代謝・血液・膠原病内科学講座（第二内科）・大分大学医学部 消化器・小児外科学講座, 那覇, Japan, Domestic conference肥満が大腸癌腫瘍微小環境のCD4陽性T細胞に及ぼす影響Oral presentation
- 第35回日本バイオセラピィ学会学術集会総会, Japanese, 福島県立医科大学 消化管外科学講座, 福島, Japan, Domestic conference大腸癌の腫瘍免疫微小環境における CD4 陽性T細胞に与える肥満の影響Oral presentation
- 第35回日本バイオセラピィ学会学術集会総会, Japanese, 福島県立医科大学 消化管外科学講座, 福島, Japan, Domestic conference放射線治療における腫瘍内 CD8+T細胞の動態Public symposium
- 第84回日本臨床外科学会総会, Japanese, 久留米大学医学部外科学講座, 福岡, Japan, Domestic conference周術期チーム医療による腹臥位胸腔鏡下食道切除術Public symposium
- 第52回胃外科・術後障害研究会, Japanese, 静岡県立静岡がんセンター 胃外科, 沼津/Web, Japan, Domestic conference残胃癌に対する腹腔鏡下残胃全摘術の手術成績の検討Public symposium
- 第52回胃外科・術後障害研究会, Japanese, 静岡県立静岡がんセンター 胃外科, 沼津/Web, Japan, Domestic conference幽門側胃切除後の残胃内容排出遅延に関する検討Public symposium
- 第52回胃外科・術後障害研究会, Japanese, 静岡県立静岡がんセンター 胃外科, 沼津/Web, Japan, Domestic conference術前欠損歯数が胃癌術後患者の予後に及ぼす影響についての検討Oral presentation
- 第33回日本消化器癌発生学会総会, Japanese, 東京大学大学院医学系研究科消化管外科学, 東京/Web, Japan, Domestic conference大腸癌のおけるCD4陽性T細胞の抗腫瘍免疫に及ぼす肥満の影響Public symposium
- Annual Congress of KSS 2022 & 74th Congress of the Korean Surgical Society, English, Korean Surgical Society, Seoul, Korea, Republic of, Domestic conferenceLaparoscopic Endoscopic Cooperative Surgery Using Openwindow Suturing Technique for Treating Non-ampullary Superficial Duodenal Neoplasms Located on the Pancreatic SideOthers
- Annual Congress of KSS 2022 & 74th Congress of the Korean Surgical Society, English, Korean Surgical Society, Seoul, Korea, Republic of, Domestic conferenceComparison of Laparoscopic Gastrectomy for Gastric Cancer with 3D and 2D MonitorsPublic symposium
- JDDW2022(第30回日本消化器関連学会週間), Japanese, 一般社団法人 日本消化器関連学会機構（JDDW）, 福岡/Web, Japan, Domestic conference食道胃接合部に近接する胃消化管間質腫瘍に対する腹腔鏡下局所切除の安全性についての検討Poster presentation
- JDDW2022(第30回日本消化器関連学会週間), Japanese, 一般社団法人 日本消化器関連学会機構（JDDW）, 福岡/Web, Japan, Domestic conferenceオープンソースの物体検出アルゴリズムYOLOv3を用いた胸腔鏡下食道亜全摘術の手術動画解析Poster presentation
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conference術前欠損歯数が胃癌術後患者の予後に及ぼす影響についての検討Oral presentation
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conferencecStageIV胃癌に対するconversion surgeryの手術成績と予後因子の検討Public symposium
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conference鼠経リンパ節転移を伴う直腸癌に対する術前治療と選択的鼠経郭清の臨床的意義Poster presentation
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conference術前化学療法における Alb/ dNLR の推移は食道癌の予後に関与するかPoster presentation
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conference直腸癌術前化学放射線療法の予後因子としての modified Glasgow Prognostic ScoreOral presentation
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conference直腸癌術前化学放射線療法における AI を用いた腫瘍組織 CD8+T 細胞の評価方法の検討Oral presentation
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conferenceFDG-PET/CTによる進行胃癌の病理学的病期の術前予測の有用性Poster presentation
- 第75回日本胸部外科学会定期学術集会, Japanese, 東京大学医学部附属病院 呼吸器外科, 横浜/Web, Japan, Domestic conference腹臥位胸腔鏡下食道切除術における腹部操作アプローチの比較（LAP vs HALS）Oral presentation
- 18th ISDE World Congress for Esophageal Diseases, English, International Society for Diseases of the Esophagus, Web, International conferenceComparison of Laparoscopic Surgeries With or Without Hand-Assisted Procedure in the Abdominal Phase of Thoracoscopic Esophagectomy in the Prone PositionPoster presentation
- 第76回日本食道学会学術集会, Japanese, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, Japan, Domestic conferenceロボット支援食道切除術の利点と課題Poster presentation
- 第76回日本食道学会学術集会, Japanese, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, Japan, Domestic conferenceAlbumin-derived NLR score is a novel prognostic marker for esophageal squamous cell carcinomaPoster presentation
- 第76回日本食道学会学術集会, Japanese, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, Japan, Domestic conference胸腔鏡下食道切除症例における栄養介入としての腸瘻チューブ留置期間の検討Poster presentation
- 第76回日本食道学会学術集会, Japanese, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, Japan, Domestic conference腹臥位胸腔鏡下食道切除術における腹部操作アプローチの比較（LAP vs HALS）Oral presentation
- 第76回日本食道学会学術集会, Japanese, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, Japan, Domestic conference低侵襲と合併症リスクの低減を目指した腹腔鏡下胸骨後経路作成の術後成績Oral presentation
- 第35回近畿内視鏡外科研究会, Japanese, 兵庫医科大学消化器外科学講座上部消化管外科, 西宮, Japan, Domestic conference当院における右側結腸癌に対する体腔内吻合の導入と治療成績Oral presentation
- 第35回近畿内視鏡外科研究会, Japanese, 兵庫医科大学消化器外科学講座上部消化管外科, 西宮, Japan, Domestic conference当院における右側結腸癌に対する対腔内吻合の導入と治療成績Oral presentation
- 第35回近畿内視鏡外科研究会, Japanese, 兵庫医科大学消化器外科学講座上部消化管外科, 西宮, Japan, Domestic conferenceSiewert Ⅱ型接合部癌に対する経裂孔的アプローチによる下縦隔リンパ節郭清Public symposium
- 第35回近畿内視鏡外科研究会, Japanese, 兵庫医科大学消化器外科学講座上部消化管外科, 西宮, Japan, Domestic conference食道切除・胸骨後再建後胃管切除に対する仰臥位胸腔鏡アプローチOral presentation
- 第35回近畿内視鏡外科研究会, Japanese, 兵庫医科大学消化器外科学講座上部消化管外科, 西宮, Japan, Domestic conference膵･十二指腸･横行結腸浸潤を伴う胃癌に対し術前化学療法奏効後に腹腔鏡下幽門側胃切除術を施行した一例Oral presentation
- 第35回近畿内視鏡外科研究会, Japanese, 兵庫医科大学消化器外科学講座上部消化管外科, 西宮, Japan, Domestic conference腹臥位胸腔鏡下食道切除における当科の郭清概念Public symposium
- 第35回近畿内視鏡外科研究会, Japanese, 兵庫医科大学消化器外科学講座上部消化管外科, 西宮, Japan, Domestic conference直腸癌手術におけるTaTMEの有用性Public symposium
- Korea International Gastric Cancer Week 2022 (KINGCA WEEK 2022), English, The Korean Gastric Cancer Association, Suwon, Korea, Republic of, International conferencePreoperative Prediction of the Pathological Stage of Advanced Gastric Cancer by 18F-fluoro-2-deoxyglucose Positron Emission TomographyOral presentation
- Korea International Gastric Cancer Week 2022 (KINGCA WEEK 2022), English, The Korean Gastric Cancer Association, Suwon, Korea, Republic of, International conferenceAssessment of Risk Factors for Delayed Gastric Emptying After Distal Gastrectomy for Gastric CancerOral presentation
- 第77回日本消化器外科学会総会, English, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conferenceLaparoscopic retrosternal route creation for gastric conduit - efficacy and outcomes 腹腔鏡による胸骨後経路作成の工夫と術後成績Public symposium
- 第77回日本消化器外科学会総会, English, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conferenceDevelopment of a new method for evaluation of rectal cancer after neoadjuvant chemoradiotherapy 直腸癌術前化学放射線療法における腫瘍組織CD8+T細胞の新たな評価方法の開発Public symposium
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conference食道胃接合部に近接する胃GISTに対する腹腔鏡下局所切除の安全性についての検討Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conference術前サルコペニアの層別化による短期・長期リスク評価の有用性Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conference下部直腸癌手術におけるTaTMEの有用性Public symposium
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conference胃癌におけるFDG-PET検査によるリンパ節SUVmax値を用いたリンパ節転移診断の有用性の検討Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conference幽門側胃切除後の胃内容排出遅延の発症リスクと治療法に関する検討Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conference術前欠損歯数が胃癌術後患者の予後に及ぼす影響についての検討Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conference抗凝固療法中の患者に対する胃切除術の安全性についてOral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conference胸腔鏡下食道切除症例における腸瘻チューブ留置による栄養介入とその意義Public symposium
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conference当院における右側結腸癌に対する体腔内吻合の手術手技と短期成績Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conferencecStageⅣ胃癌に対するconversion surgeryの治療成績Public symposium
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conference胃癌大弯側リンパ節郭清時に周囲リンパ節の郭清ラインとの連続性を意識した#4sb郭清手技の有用性Public symposium
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conference低肺機能患者に対する腹臥位胸腔鏡下食道切除術Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conference直腸悪性腫瘍に対するHybrid手術の短期成績に関する後ろ向き研究Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conferenceSiewert II型食道胃接合部癌に対する偽His角・穹窿部を付加したy字様Overlap食道胃管吻合の有用性Public symposium
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan, Domestic conference頭側アプローチによる腹腔鏡下結腸右半切除～術者経験を考慮した段階的導入と定型化～Public symposium
- 第97回大腸癌研究会学術集会, Japanese, 埼玉医科大学総合医療センター 消化管・一般外科, 東京/Web, Japan, Domestic conference閉塞性大腸癌患者に対する腹腔鏡下手術の術前自己拡張型金属ステントの有用性Oral presentation
- 第44回日本癌局所療法研究会, Japanese, 独立行政法人 労働者健康安全機構 関西労災病院, 大阪, Japan, Domestic conference遠隔転移を有するHER2陽性進行胃癌に対しConversion Surgeryを施行し奏効を得た1例Oral presentation
- 第44回日本癌局所療法研究会, Japanese, 独立行政法人 労働者健康安全機構 関西労災病院, 大阪, Japan, Domestic conference食道癌に対するESD後の良性狭窄に対し食道バイパス手術によりQOL向上を得られた一例Oral presentation
- 第31回日本癌病態治療研究会, Japanese, 徳島大学消化器 移植外科学, 鳴門/Web, Japan, Domestic conference術前化学療法における Alb-dNLR ratioの推移は食道癌の予後に関与するかPoster presentation
- 第31回日本癌病態治療研究会, Japanese, 徳島大学消化器 移植外科学, 鳴門/Web, Japan, Domestic conference大腸癌免疫微小環境におけるCD4陽性T細胞に及ぼす肥満の影響Poster presentation
- 第31回日本癌病態治療研究会, Japanese, 徳島大学消化器 移植外科学, 鳴門/Web, Japan, Domestic conference放射線治療における腫瘍内 CD8+T 細胞の動態Public symposium
- 第31回日本癌病態治療研究会, Japanese, 徳島大学消化器 移植外科学, 鳴門/Web, Japan, Domestic conferencecStageIV胃癌に対するconversion surgeryの予後の検討Poster presentation
- 第31回日本癌病態治療研究会, Japanese, 徳島大学消化器 移植外科学, 鳴門/Web, Japan, Domestic conference低侵襲治療を目指したロボット支援下胃切除術の導入と短期治療成績Poster presentation
- 第65回関西胸部外科学会学術集会, Japanese, 浜松医科大学 外科学第一講座, 浜松, Japan, Domestic conference食道切除・胸骨後再建後胃管癌に対する仰臥位胸腔鏡アプローチPublic symposium
- AOS 2022（2nd International Congress of ASIAN ONCOLOGY SOCIETY), English, Asian Oncology Society, Seoul/Web, Korea, Republic of, International conferenceThoracic cavity-to-cage ratio is a predictor of technical difficulties in minimally invasive esophagectomyOral presentation
- 第43回癌免疫外科研究会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都, Japan, Domestic conference腫瘍抗原導入樹状細胞にiNKT細胞リガンドを付加したワクチンは、抗原特異的な抗腫瘍免疫を効果的に誘導するPublic symposium
- 第43回癌免疫外科研究会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都, Japan, Domestic conference放射線治療における腫瘍内CD8+T細胞の動態Public symposium
- 第76回手術手技研究会, Japanese, 佐賀大学医学部 一般・消化器外科, 佐賀/Web, Japan, Domestic conference腹腔鏡による胸骨後経路作成の工夫と短期成績Public symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan, Domestic conference術前化学療法におけるAlb/dNLRの推移は食道癌の予後に関与するかPublic symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan, Domestic conference術前欠損歯数が胃癌予後に及ぼす影響についての検討Poster presentation
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan, Domestic conference食道胃接合部に近接する胃GISTに対する腹腔鏡下局所切除の安全性についての検討Poster presentation
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan, Domestic conferenceサルコペニアの層別化によるリスク評価の有用性Poster presentation
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan, Domestic conferenceMIE施行症例における術前血小板リンパ球比の予後予測因子としての有用性Public symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan, Domestic conference当科における下部進行直腸癌に対する治療戦略Public symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan, Domestic conference高齢胃癌患者への内視鏡治療後非治癒切除症例における予後の検討Poster presentation
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan, Domestic conference胃・食道胃接合部癌術前化学療法における予後予測因子の検討Public symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan, Domestic conference2チームによるTaTMEは狭骨盤や肥満による腹腔鏡下直腸癌手術の困難さを緩和するPublic symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan, Domestic conference直腸癌術前化学放射線療法における腫瘍内レジデントメモリーCD8+T細胞の動態とその予後Public symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan, Domestic conference下部直腸癌に対するTaTMEと融合させたRobotic surgeryPublic symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan, Domestic conferenceロボット支援食道切除におけるlearning curveと手技の工夫Public symposium
- 第94回日本胃癌学会総会, English, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, Japan, Domestic conferenceThe Signicance of Surgical Intervention Following Chemotherapy for Stage IV Gastric CancerOral presentation
- 第94回日本胃癌学会総会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, Japan, Domestic conference幽門側胃切除後の胃内容排出遅延の発症リスクと治療法に関する検討Public symposium
- 第94回日本胃癌学会総会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, Japan, Domestic conference抗血栓療法中の患者に対する胃癌手術の安全性の検討Poster presentation
- 第94回日本胃癌学会総会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, Japan, Domestic conferenceda Vinci Harmonicによるロボット支援下幽門側胃切除術の時間短縮効果と短期治療成績の検討Oral presentation
- 第14回日本ロボット外科学会学術集会, Japanese, 鹿児島大学医学部産科婦人科, Web, Japan, Domestic conferenceロボット支援食道切除における反回神経麻痺低減の試みPublic symposium
- 第54回制癌剤適応研究会, Japanese, 富山大学消化器・腫瘍・総合外科, Web/誌上開催, Japan, Domestic conference癌幹細胞マーカーは食道扁平上皮癌に対する術前化学療法の治療効果予測に有用であるPublic symposium
- 第54回制癌剤適応研究会, Japanese, 富山大学消化器・腫瘍・総合外科, Web/誌上開催, Japan, Domestic conference大腸癌腹膜播種モデルにおける骨髄由来免疫抑制細胞の機能Public symposium
- 第54回制癌剤適応研究会, Japanese, 富山大学消化器・腫瘍・総合外科, Web/誌上開催, Japan, Domestic conference術前化学療法を施行した食道癌切除症例の予後を予測するバイオマーカーとしての血小板-リンパ球比の意義Public symposium
- 第96回大腸癌研究会, Japanese, 帝京大学医学部外科学講座, 東京/Web, Japan, Domestic conference当科における経肛門アプローチ併用による側方リンパ節郭清の手術成績Oral presentation
- 第34回日本内視鏡外科学会総会, Japanese低肺機能に対する腹臥位胸腔鏡下食道切除術Oral presentation
- 第34回日本内視鏡外科学会総会, Japaneseロボット支援食道切除術においてenergy deviceが短期成績に及ぼす影響Oral presentation
- 第34回日本内視鏡外科学会総会, Japanese当院における右側結腸癌に対する体腔内吻合の導入と治療成績Oral presentation
- 第34回日本内視鏡外科学会総会, Japanese腹腔鏡下胃切除症例における周術期抗血栓療法の安全性の検討Oral presentation
- 第34回日本内視鏡外科学会総会, Japanese当院におけるロボット支援下幽門側胃切除術の手技定型化の確立と短期治療成績Oral presentation
- 第34回日本内視鏡外科学会総会, Japaneseロボット支援食道手術による反回神経麻痺の軽減に関する試みOral presentation
- 第34回日本内視鏡外科学会総会, Japanese直腸癌手術におけるTransanal minimally invasive ISRの有用性と課題Oral presentation
- 第34回日本内視鏡外科学会総会, Japaneseロボット支援食道切除における至適剥離層Public symposium
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, Japanese直腸癌に対するAbdominal robotic approach併用によるHybrid TaTMEPoster presentation
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, Japanese大腸癌術後の早期再発のリスク因子Poster presentation
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, Japanese癌幹細胞マーカーは、食道扁平上皮癌に対する術前化学療法の治療効果予測に有用であるPoster presentation
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, Japanese腫瘍抗原導入樹状細胞にα-GalCerを付加したワクチンベクターの抗腫瘍効果Poster presentation
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, Japanese術前化学療法を施行した食道癌切除症例の予後を予測するバイオマーカーとしての血小板-リンパ球比の意義Poster presentation
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, Japanese当科におけるStageⅣ胃癌に対するconversion surgeryの治療成績Poster presentation
- 第30回日本コンピュータ外科学会大会, Japanese胸腔鏡下食道切除術における3D内視鏡システムは術後短期成績の改善に寄与するOral presentation
- 第30回日本コンピュータ外科学会大会, Japaneseロボット支援食道切除手術におけるlearning curveOral presentation
- 第30回日本コンピュータ外科学会大会, Japanese3D/HDおよび2D/4Kモニターが術者技術レベルごとの手術操作にもたらす影響Oral presentation
- 第30回日本コンピュータ外科学会大会, Japanese3D‒CT を用いた骨盤計測と直腸癌手術時間との関連―通常の腹腔鏡下手術と Transanal Total Mesorectal Excision との違い―Oral presentation
- 第72回日本気管食道科学会総会ならびに学術講演会, Japaneseオープンソースの物体検出アルゴリズムYOLOv3を用いた胸腔鏡下食道亜全摘術の手術動画解析Public symposium
- 第72回日本気管食道科学会総会ならびに学術講演会, Japanese胸腔鏡下食道切除術における嚥下性肺炎の予防Public symposium
- 第51回胃外科・術後障害研究会, Japanese幽門側胃切除後の残胃内容排出遅延に関する検討Public symposium
- 第59回日本癌治療学会学術集会, JapaneseTaTMEを軸とした近未来の下部直腸癌手術Public symposium
- 日本外科代謝栄養学会第58回学術集会, Japanese胃癌手術症例における欠損歯が予後に及ぼす影響についてOral presentation
- 日本外科代謝栄養学会第58回学術集会, Japanese食道癌患者における術前のサルコペニア予測サロゲートマーカーの開発Oral presentation
- 第27回外科侵襲とサイトカイン研究会, Oct. 2021, Japanese大腸癌免疫微小環境におけるCD4陽性T細胞に及ぼす肥満の影響Public symposium
- 第34回近畿内視鏡外科研究会, Sep. 2021, Japaneseロボット支援食道切除術の短期成績と learning curveOral presentation
- 第34回近畿内視鏡外科研究会, Sep. 2021, Japanese腹臥位胸腔鏡下食道切除術における上縦隔郭清手技の工夫と定型化Oral presentation
- 第34回近畿内視鏡外科研究会, Sep. 2021, Japanese当院における腹腔鏡下胃切除を安全に行うためのちょっとした工夫Public symposium
- 第34回近畿内視鏡外科研究会, Sep. 2021, Japanese直腸癌手術における Robotic TaTME の可能性Public symposium
- 第34回近畿内視鏡外科研究会, Sep. 2021, Japanese当科におけるロボット支援食道手術の課題と可能性Public symposium
- 第75回日本食道学会学術集会Laparoscopic retrosternal route creation; short-term postoperative outcomesPoster presentation
- 第75回日本食道学会学術集会Established upper mediastinum lymphadenectomy in prone MIE improves outcomesOral presentation
- 第75回日本食道学会学術集会Validity of lymphadenectomy for No.106recL estimated by Efficacy IndexPublic symposium
- 第76回日本消化器外科学会総会, Japanese腹腔鏡による胸骨後経路作成の工夫と短期成績Oral presentation
- 第76回日本消化器外科学会総会, Japanese至適術前治療選択のためのバイオマーカーの重要性Oral presentation
- 第76回日本消化器外科学会総会, EnglishEstablished upper mediastinum lymphadenectomy in prone MIE improves outcomesPublic symposium
- 第76回日本消化器外科学会総会, EnglishPotential of robotic surgery surpassing conventional thoracoscopic esophagectomyPublic symposium
- 第31回日本サイトメトリー学会学術集会, Japanese大腸癌腹膜播腫モデルにおける骨髄由来免疫抑制細胞の機能Oral presentation
- 第75回手術手技研究会, Japanese食道切除・胸骨後再建後胃管癌に対する仰臥位胸腔鏡アプローチPublic symposium