Research activity information

• Jun. 2024 13th International Colloids Conference, Best Poster Prize, Molecular aggregation strategy for inhibiting DNases

  Kenta Morita, Tomoko Moriwaki, Shunsuke Habe, Mariko Taniguchi-Ikeda, Tadao Hasegawa, Yusuke Minato, Takashi Aoi, Tatsuo Maruyama


• May 2022 高分子学会, The society of polymer science, publicity awards, がん細胞の内部をゲル化してアポトーシス死を導くペプチド型抗がん剤の開発

  Kenta Morita, Kanon Nishimura, Shota Yamamoto, Natsumi Shimizu, Takashi Aoi, Atsuo Tamura, Tatsuo Maruyama


• Aug. 2021 株式会社ストラテジック, IRMAIL science grant, がん細胞を"内側から固めて"殺す自己組織化ペプチド薬の抗がん作用機序の実証

  Kenta Morita

• Catalase-Knockout Complements the Radio-Sensitization Effect of Titanium Peroxide Nanoparticles on Pancreatic Cancer Cells

  Winda Tasia, Amane Washio, Koki Yamate, Kenta Morita, Yutaro Mori, Prihardi Kahar, Ryohei Sasaki, Chiaki Ogino

  Jan. 2025, Molecules

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Size- and Wavelength-Selective Optical Heating in Mie-Resonant Silicon Nanospheres for Nanothermometry and Photothermal Applications

  Kana Kondo, Mojtaba Karimi Habil, Kojiro Senda, Masato Adachi, Kenta Morita, Tatsuo Maruyama, Hiroshi Sugimoto, Minoru Fujii

  Oct. 2024, ACS Applied Nano Materials

  [Refereed]

  Scientific journal


• Scattering/Fluorescence Dual-Mode Imaging in MnO2-Coated Silicon Nanospheres for Cancer Cell Detection.

  Masato Adachi, Hiroshi Sugimoto, Kenta Morita, Tatsuo Maruyama, Minoru Fujii

  A tumor microenvironment (TME)-responsive nanoprobe composed of a fluorescent dye-decorated silicon (Si) nanosphere core and a thin MnO2 shell is proposed for simple and intelligent detection of cancer cells. The Si nanosphere core with diameters of 100-200 nm provides environment-independent Mie scattering imaging, while, simultaneously, the MnO2 shell provides the capability to switch the on/off state of the dye fluorescence reacted to the glutathione (GSH) and/or H2O2 levels in a cancer cell. Si-MnO2 core-shell nanosphere probes are fabricated in a solution-based process from crystalline Si nanosphere cores. The fluorescence switching under exposure to GSH is demonstrated, and the mechanism is discussed based on detailed optical characterizations including single-particle spectroscopy. Different types of human cells are incubated with the nanoprobes, and a proof of concept experiment is performed. From the combination of the robust scattering images and GSH- and H2O2-sensitive fluorescence images, the feasibility of cancer cell detection by the multimodal nanoprobes is demonstrated.

  Jul. 2024, ACS applied materials & interfaces, 16(26) (26), 33963 - 33970, English, International magazine

  [Refereed]

  Scientific journal


• Molecular Aggregation Strategy for Inhibiting DNases.

  Kenta Morita, Tomoko Moriwaki, Shunsuke Habe, Mariko Taniguchi-Ikeda, Tadao Hasegawa, Yusuke Minato, Takashi Aoi, Tatsuo Maruyama

  This study highlights the novel potential of molecular aggregates as inhibitors of a disease-related protein. Enzyme inhibitors have been studied and developed as molecularly targeted drugs and have been applied for cancer, autoimmune diseases, and infections. In many cases, enzyme inhibitors that are used for therapeutic applications interact directly with enzymes in a molecule-to-molecule manner. We found that the aggregates of a small compound, Mn007, inhibited bovine pancreatic DNase I. Once Mn007 molecules formed aggregates, they exhibited inhibitory effects specific to DNases that require divalent metal ions. A DNase secreted by Streptococcus pyogenes causes streptococcal toxic shock syndrome (STSS). STSS is a severe infectious disease with a fatality rate exceeding 30% in patients, even in this century. S. pyogenes disrupts the human barrier system against microbial infections through the secreted DNase. Until now, the discovery/development of a DNase inhibitor has been challenging. Mn007 aggregates were found to inhibit the DNase secreted by S. pyogenes, which led to the successful suppression of S. pyogenes growth in human whole blood. To date, molecular aggregation has been outside the scope of drug discovery. The present study suggests that molecular aggregation is a vast area to be explored for drug discovery and development because aggregates of small-molecule compounds can inhibit disease-related enzymes.

  Lead, Jun. 2024, JACS Au, 4(6) (6), 2262 - 2266, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Thermal conductivity of epoxy resin films doped with a polythiophene/graphene complex or aluminum nitride

  Tatsuo Maruyama, Yudai Tominaga, Junko Kado, Kenta Morita, Tomoko Moriwaki, Yoshi Kusamoto, Tomohiro Yoshitomi, Atsunori Mori, Takashi Nishino

  Abstract Polymer composites with thermal conductivity are attractive for heat dissipation in electronic devices. We prepared epoxy resin‐based composite films filled with polythiophene [poly(3‐hexylthiophene‐2,5‐diyl)] (P3HT)/graphene complex or aluminum nitride (AlN). The composite films were characterized by electron microscopic observation, thermogravimetric analysis, and thermal conductivity measurements. The addition of a small content of P3HT/graphene complex (<1 wt%) increased both the out‐of‐plane and in‐plane thermal conductivities of the epoxy resin. The addition of AlN also increased thermal conductivity, but ≥40 wt% was required to obtain thermal conductivity comparable with that of an epoxy resin film doped with 0.9 wt% P3HT/graphene complex. The present results illustrate the potential of P3HT/graphene complexes as fillers for improving the thermal conductivity of epoxy resins without affecting their insulating properties. Highlights Polythiophene/graphene fillers increased epoxy resin films' thermal conductivity. To raise the thermal conductivity of epoxy resin films high AlN content was needed. In‐plane/out‐of‐plane epoxy resin films' thermal conductivities were evaluated.

  Wiley, May 2024, Polymer Composites, 45(12) (12), 11104 - 11111

  [Refereed]

  Scientific journal


• Microplate-Based Cryopreservation of Adherent-Cultured Human Cell Lines Using Amino Acids and Proteins

  Kenta Morita, Tomoko Yashiro, Takashi Aoi, Ryutaro Imamura, Tomoyuki Ohtake, Norihiro Yoshizaki, Tatsuo Maruyama

  With the progression of regenerative medicine and cell therapy, the importance of cryopreservation techniques for cultured cells continues to rise. Traditional cryoprotectants, such as dimethyl sulfoxide and glycerol, are effective in cryopreserving suspended cells, but they do not demonstrate sufficient efficacy for two-dimensional (2D)-cultured cells. In the past decade, small molecules and polymers have been studied as cryoprotectants. Some L-amino acids have been reported to be natural and biocompatible cryoprotectants. However, the cryoprotective effects of D-amino acids have not been investigated for such organized cells. In the present study, the cryoprotective effects of D- and L-amino acids and previously reported cryoprotectants were assessed using HepG2 cells cultured on a microplate without suspending the cells. d-Proline had the highest cryoprotective effect on 2D-cultured cells. The composition of the cell-freezing solution and freezing conditions were then optimized. The d-proline-containing cell-freezing solution also effectively worked for other cell lines. To minimize the amount of animal-derived components, fetal bovine serum in the cell freezing solution was substituted with bovine serum albumin and StemFit (a commercial supplement for stem cell induction). Further investigations on the mechanism of cryopreservation suggested that d-proline protected enzymes essential for cell survival from freeze-induced damage. In conclusion, an effective and xeno-free cell-freezing solution was produced using d-proline combined with dimethyl sulfoxide and StemFit for 2D-cultured cells.

  Lead, American Chemical Society (ACS), Mar. 2024, ACS Biomaterials Science & Engineering, 10(4) (4), 2442 - 2450, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Nanoscopic lignin mapping on cellulose nanofibers via scanning transmission electron microscopy and atomic force microscopy

  Kenta Morita, Musashi Takenaka, Kohei Tomita, Jun Ishii, Hideo Kawaguchi, Daisuke Murakami, Hikaru Amo, Miku Fujii, Tatsuo Maruyama, Takuya Matsumoto, Takashi Nishino, Chiaki Ogino

  Abstract Cellulose has been developed as an alternative to petrochemical materials. By comparison with refined nanofibers (RCNFs), lignocellulose nanofibers (LCNFs) show particular promise because it is produced from biomass using only mild pretreatment. The mechanical properties of LCNFs depend on the contained lignin. However, the microscopic location of the lignin contained in LCNFs has not been determined. Thus, we developed two methods to detect and visualize lignin. One uses a scanning transmission electron microscope (STEM) equipped with an energy dispersive X-ray spectroscopy detector. The other method uses an atomic force microscope (AFM) equipped with a cantilever coated with an aromatic molecule. Both methods revealed that the lignin in LCNFs covers a thin cellulose fiber and is precipitated in a grained structure. In particular, the AFM system was able to determine the nanoscopic location of lignin-rich areas. The present study establishes a strong tool for analyzing the characteristics of lignin-containing materials. Graphical abstract

  Lead, Springer Science and Business Media LLC, Nov. 2023, Cellulose, 30(18) (18), 11357 - 11367

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Micelle-like Nanoassemblies of Short Peptides Create Antimicrobial Selectivity in a Conventional Antifungal Drug

  Kenta Morita, Yuya Nishimura, Jun Ishii, Tatsuo Maruyama

  Lead, Jan. 2023, ACS Applied Nano Materials, 6(2) (2), 1432 - 1440

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Fluorophore‐Decorated Mie Resonant Silicon Nanosphere for Scattering/Fluorescence Dual‐Mode Imaging

  Masato Adachi, Hiroshi Sugimoto, Yuya Nishimura, Kenta Morita, Chiaki Ogino, Minoru Fujii

  Wiley, Jan. 2023, Small, 19(14) (14), 2207318 - 2207318, English, International magazine

  [Refereed]

  Scientific journal


• Thermally irreversible supramolecular hydrogels record thermal history

  Yudai Tominaga, Sayuki Kanemitsu, Shota Yamamoto, Toshihisa Kimura, Yuki Nishida, Kenta Morita, Tatsuo Maruyama

  Jan. 2023, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 656

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• In Situ Synthesis of an Anticancer Peptide Amphiphile Using Tyrosine Kinase Overexpressed in Cancer Cells

  Kenta Morita, Kanon Nishimura, Shota Yamamoto, Natsumi Shimizu, Tomoko Yashiro, Ryoko Kawabata, Takashi Aoi, Atsuo Tamura, Tatsuo Maruyama

  Lead, Sep. 2022, JACS Au, 2(9) (9), 2023 - 2028, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Inhibition of Melittin Activity Using a Small Molecule with an Indole Ring

  Sayuki Kanemitsu, Kenta Morita, Yudai Tominaga, Kanon Nishimura, Tomoko Yashiro, Haruka Sakurai, Yumemi Yamamoto, Ikuo Kurisaki, Shigenori Tanaka, Masaki Matsui, Tooru Ooya, Atsuo Tamura, Tatsuo Maruyama

  Aug. 2022, The Journal of Physical Chemistry B, 126(31) (31), 5793 - 5802, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosensitizers for eliminating pancreatic cancer stem cells

  Mohammed Salah, Hiroaki Akasaka, Yasuyuki Shimizu, Kenta Morita, Yuya Nishimura, Hikaru Kubota, Hiroki Kawaguchi, Tomomi Sogawa, Naritoshi Mukumoto, Chiaki Ogino, Ryohei Sasaki

  Apr. 2022, JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 41(1) (1), 146 - 146, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Rewritable Surface on a Plastic Substrate Using Fluorous Affinity

  Takane Tsuchii, Kazuki Kaneko, Kenta Morita, Takashi Nishino, Tatsuo Maruyama

  Jan. 2022, ACS APPLIED MATERIALS & INTERFACES, 14(2) (2), 3255 - 3263, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy

  Masao Nakayama, Hiroaki Akasaka, Eiichi Miyazaki, Yoshihiro Goto, Yuya Oki, Yosuke Kawate, Kenta Morita, Ryohei Sasaki

  Oct. 2021, PHYSICS & IMAGING IN RADIATION ONCOLOGY, 20, 94 - 97, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Covalent immobilization of gold nanoparticles on a plastic substrate and subsequent immobilization of biomolecules

  Mimari Matsumoto, Kazuki Kaneko, Manami Hara, Masaki Matsui, Kenta Morita, Tatsuo Maruyama

  Jul. 2021, RSC ADVANCES, 11(38) (38), 23409 - 23417, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Microenvironment pH-Induced Selective Cell Death for Potential Cancer Therapy Using Nanofibrous Self-Assembly of a Peptide Amphiphile

  Shota Yamamoto, Kanon Nishimura, Kenta Morita, Sayuki Kanemitsu, Yuki Nishida, Tomoyuki Morimoto, Takashi Aoi, Atsuo Tamura, Tatsuo Maruyama

  Jun. 2021, BIOMACROMOLECULES, 22(6) (6), 2524 - 2531, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Medical Application of Titanium Peroxide Nanoparticles for Cancer Radiotherapy

  佐々木 良平, 中山 雅央, 森田 健太, 赤坂 浩亮, 荻野 千秋

  Apr. 2021, 化學工業, 72(4) (4), 244 - 251, Japanese

  [Refereed][Invited]


• ウサギVX2腫瘍モデルを用いた過酸化チタンナノ粒子動注の基礎的研究

  岡田 卓也, 元津 倫幸, 西村 勇哉, 森田 健太, 上嶋 英介, 山口 雅人, 杉本 幸司, 佐々木 良平, 荻野 千秋, 村上 卓道

  (一社)日本インターベンショナルラジオロジー学会, Apr. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 191 - 191, Japanese


• Preparation of affinity membranes using polymer phase separation and azido-containing surfactants

  Kenta Morita, Shinano Takeda, Ayumi Yunoki, Takane Tsuchii, Tsutomu Tanaka, Tatsuo Maruyama

  Lead, Feb. 2021, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 611, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Titanium oxide nano-radiosensitizers for hydrogen peroxide delivery into cancer cells

  Kenta Morita, Yuya Nishimura, Satoko Nakamura, Yuki Arai, Chiya Numako, Kazuyoshi Sato, Masao Nakayama, Hiroaki Akasaka, Ryohei Sasaki, Chiaki Ogino, Akihiko Kondo

  Lead, Feb. 2021, COLLOIDS AND SURFACES B-BIOINTERFACES, 198, 111451 - 111451, English, International magazine

  [Refereed]

  Scientific journal


• Comparative analyses of site-directed mutagenesis of human melatonin MTNR1A and MTNR1B receptors using a yeast fluorescent biosensor

  Yasuyuki Nakamura, Ririka Asama, Takuya Tabata, Kenta Morita, Tatsuo Maruyama, Akihiko Kondo, Jun Ishii

  Feb. 2021, BIOTECHNOLOGY AND BIOENGINEERING, 118(2) (2), 863 - 876, English, International magazine

  [Refereed]

  Scientific journal


• In Vivo Evaluation of the Z(HER2)-BNC/LP Carrier Encapsulating an Anticancer Drug and a Radiosensitizer

  Yuya Nishimura, Ryosuke Ezawa, Kenta Morita, Masao Nakayama, Jun Ishii, Ryohei Sasaki, Chiaki Ogino, Akihiko Kondo

  Nov. 2020, ACS APPLIED BIO MATERIALS, 3(11) (11), 7743 - 7751, English, International magazine

  [Refereed]

  Scientific journal


• Valorization of palm biomass waste into carbon matrices for the immobilization of recombinant Fusarium heterosporum lipase towards palm biodiesel synthesis

  Emmanuel Quayson, Jerome Amoah, Nova Rachmadona, Kenta Morita, Lawrence Darkwah, Shinji Hama, Ayumi Yoshida, Akihiko Kondo, Chiaki Ogino

  Nov. 2020, BIOMASS & BIOENERGY, 142, English

  [Refereed]

  Scientific journal


• Investigation of the potential of using TiO2 nanoparticles as a contrast agent in computed tomography and magnetic resonance imaging

  Hiroaki Akasaka, Naritoshi Mukumoto, Masao Nakayama, Tianyuan Wang, Ryuichi Yada, Yasuyuki Shimizu, Sachiko Inubushi, Katsusuke Kyotani, Keisuke Okumura, Masanori Miyamoto, Ai Nakaoka, Kenta Morita, Yuya Nishimura, Chiaki Ogino, Ryohei Sasaki

  Aug. 2020, APPLIED NANOSCIENCE, 10(8) (8), 3143 - 3148, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Samarium doped titanium dioxide nanoparticles as theranostic agents in radiation therapy

  Masao Nakayama, Clare L. Smith, Bryce N. Feltis, Terrence J. Piva, Farnaz Tabatabaie, Peter D. Harty, Frank M. Gagliardi, Kirsten Platts, Sarah Otto, Anton Blencowe, Kenta Morita, Moshi Geso

  Jul. 2020, PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 75, 69 - 76, English, International magazine

  [Refereed]

  Scientific journal


• A Comparative Assessment of Mechanisms and Effectiveness of Radiosensitization by Titanium Peroxide and Gold Nanoparticles

  Mennaallah Hassan, Masao Nakayama, Mohammed Salah, Hiroaki Akasaka, Hikaru Kubota, Makiko Nakahana, Tatsuichiro Tagawa, Kenta Morita, Ai Nakaoka, Takeaki Ishihara, Daisuke Miyawaki, Kenji Yoshida, Yuya Nishimura, Chiaki Ogino, Ryohei Sasaki

  Jun. 2020, NANOMATERIALS, 10(6) (6), English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Utilisation of the chemiluminescence method to measure the radiation dose enhancement caused by gold nanoparticles: A phantom-based study

  Masao Nakayama, Hiroaki Akasaka, Moshi Geso, Kenta Morita, Ryuichi Yada, Kazuyuki Uehara, Ryohei Sasaki

  Jun. 2020, RADIATION MEASUREMENTS, 134, English

  [Refereed]

  Scientific journal


• Solidification Microstructure and Magnetic Properties of Ag-Rich Ag-Cu-La-Fe Immiscible Alloys

  Takeshi Nagase, Tomoyuki Terai, Tomoyuki Kakeshita, Kenta Morita

  2020, MATERIALS TRANSACTIONS, 61(2) (2), 311 - 317, English

  [Refereed]

  Scientific journal


• Surface-functionalization of isotactic polypropylene via dip-coating with a methacrylate-based terpolymer containing perfluoroalkyl groups and poly(ethylene glycol) (vol 51, pg 489, 2019)

  Manami Hara, Shigeru Kitahata, Keisuke Nishimori, Koki Miyahara, Kenta Morita, Kaya Tokuda, Takashi Nishino, Tatsuo Maruyama

  Dec. 2019, POLYMER JOURNAL, 51(12) (12), 1309 - 1310, English

  [Refereed]


• Combined Cell Surface Display of beta-d-Glucosidase (BGL), Maltose Transporter (MAL11), and Overexpression of Cytosolic Xylose Reductase (XR) in Saccharomyces cerevisiae Enhance Cellobiose/Xylose Coutilization for Xylitol Bioproduction from Lignocellulosic Biomass

  Gregory G. Y. Guirimand, Takahiro Bamba, Mami Matsuda, Kentaro Inokuma, Kenta Morita, Yuki Kitada, Yuma Kobayashi, Takahiro Yukawa, Kengo Sasaki, Chiaki Ogino, Tomohisa Hasunuma, Akihiko Kondo

  Sep. 2019, BIOTECHNOLOGY JOURNAL, 14(9) (9), e1800704, English, International magazine

  [Refereed]

  Scientific journal


• Versatility of a Dilute Acid/Butanol Pretreatment Investigated on Various Lignocellulosic Biomasses to Produce Lignin, Monosaccharides and Cellulose in Distinct Phases

  Quentin Schmetz, Hiroshi Teramura, Kenta Morita, Tomoko Oshima, Aurore Richel, Chiaki Ogino, Akihiko Kondo

  Jul. 2019, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 7(13) (13), 11069 - 11079, English

  [Refereed]

  Scientific journal


• Surface-functionalization of isotactic polypropylene via dip-coating with a methacrylate-based terpolymer containing perfluoroalkyl groups and poly(ethylene glycol)

  Manami Hara, Shigeru Kitahata, Keisuke Nishimori, Koki Miyahara, Kenta Morita, Kaya Tokuda, Takashi Nishino, Tatsuo Maruyama

  May 2019, POLYMER JOURNAL, 51(5) (5), 489 - 499, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Cell-surface display technology and metabolic engineering of Saccharomyces cerevisiae for enhancing xylitol production from woody biomass

  Gregory Guirimand, Kentaro Inokuma, Takahiro Bamba, Mami Matsuda, Kenta Morita, Kengo Sasaki, Chiaki Ogino, Jean-Guy Berrin, Tomohisa Hasunuma, Akihiko Kondo

  Apr. 2019, GREEN CHEMISTRY, 21(7) (7), 1795 - 1808, English

  [Refereed]

  Scientific journal


• Valorization of Activated Carbon as a Reusable Matrix for the Immobilization of Aspergillus oryzae Whole-Cells Expressing Fusarium heterosporum Lipase toward Biodiesel Synthesis

  Emmanuel Quayson, Jerome Amoah, Shinji Hama, Ayumi Yoshida, Kenta Morita, Akihiko Kondo, Chiaki Ogino

  Mar. 2019, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 7(5) (5), 5010 - 5017, English

  [Refereed]

  Scientific journal


• In vivo tissue distribution and safety of polyacrylic acid-modified titanium peroxide nanoparticles as novel radiosensitizers

  Kenta Morita, Takahiro Suzuki, Yuya Nishimura, Kazuhisa Matsumoto, Chiya Numako, Kazuyoshi Sato, Masao Nakayama, Ryohei Sasaki, Chiaki Ogino, Akihiko Kondo

  Jul. 2018, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 126(1) (1), 119 - 125, English, Domestic magazine

  [Refereed]

  Scientific journal


• A pyruvate carbon flux tugging strategy for increasing 2,3-butanediol production and reducing ethanol subgeneration in the yeast Saccharomyces cerevisiae.

  Ishii J, Morita K, Ida K, Kato H, Kinoshita S, Hataya S, Shimizu H, Kondo A, Matsuda F

  Jun. 2018, Biotechnology for biofuels, 11, 180

  [Refereed]


• A Cancer Treatment Strategy That Combines the Use of Inorganic/Biocomplex Nanoparticles With Conventional Radiation Therapy

  Kenta Morita, Yuya Nishimura, Takahiro Suzuki, Chiaki Ogino, Akihiko Kondo

  Elsevier, May 2018, Nanoparticle Technology Handbook, 439 - 443, English

  In book


• 新規放射線増感剤としての過酸化チタンナノ粒子の物性解析

  森田 健太, 西村 勇哉, 大取 靖秀, 荒井 優紀, 沼子 千弥, 荻野 千秋

  日本DDS学会, May 2018, 日本DDS学会学術集会プログラム予稿集, 34回, 207 - 207, Japanese


• Characterization of titanium dioxide nanoparticles modified with polyacrylic acid and H2O2 for use as a novel radiosensitizer

  Kenta Morita, Serika Miyazaki, Chiya Numako, Shinya Ikeno, Ryohei Sasaki, Yuya Nishimura, Chiaki Ogino, Akihiko Kondo

  Lead, Dec. 2016, FREE RADICAL RESEARCH, 50(12) (12), 1319 - 1328, English, International magazine

  [Refereed]

  Scientific journal


• Titanium peroxide nanoparticles enhanced cytotoxic effects of X-ray irradiation against pancreatic cancer model through reactive oxygen species generation in vitro and in vivo

  Masao Nakayama, Ryohei Sasaki, Chiaki Ogino, Tsutomu Tanaka, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Zhenquan Tan, Yuya Nishimura, Hiroaki Akasaka, Kazuyoshi Sato, Chiya Numako, Seiichi Takami, Akihiko Kondo

  Jul. 2016, RADIATION ONCOLOGY, 11(1) (1), 91 - 91, English, International magazine

  [Refereed]

  Scientific journal


• Titanium peroxide nanoparticles enhance antitumor efficacy through reactive oxygen species in pancreatic cancer radiation therapy

  Masao Nakayama, Ryohei Sasaki, Toru Mukohara, Chiaki Ogino, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Kazuyoshi Sato, Chiya Numako, Seiichi Takami, Akihiko Kondo

  Aug. 2015, CANCER RESEARCH, 75, English

  [Refereed]


• 新たな放射線増感剤としての過酸化チタンナノ粒子は膵癌治療における抗腫瘍効果を増強させる(Titanium Peroxide Nanoparticles, as Novel Radiosensitizers, Enhance Antitumor Efficacy in Pancreatic Cancer Therapy)

  Nakayama Masao, Sasaki Ryohei, Ogino Chiaki, Tanaka Tsutomu, Morita Kenta, Umetsu Mitsuo, Ohara Satoshi, Sato Kazuyoshi, Numako Chiya, Takami Seiichi, Kondo Akihiko

  (一社)日本放射線影響学会, May 2015, 日本放射線影響学会大会講演要旨集, 58回, 3 - 07, English


• Mutation of arginine residues to avoid non-specific cellular uptakes for hepatitis B virus core particles

  Izzat Fahimuddin Bin Mohamed Suffian, Yuya Nishimura, Kenta Morita, Sachiko Nakamura-Tsuruta, Khuloud T. Al-Jamal, Jun Ishii, Chiaki Ogino, Akihiko Kondo

  Feb. 2015, JOURNAL OF NANOBIOTECHNOLOGY, 13, 15 - 15, English, International magazine

  [Refereed]

  Scientific journal


• ラジカルを発生する金属酸化物ナノ粒子のX線を用いた分析

  宮嵜 世里加, 森田 健太, 荻野 千秋, 佐藤 和好, 沼子 千弥

  (公社)日本分析化学会, Sep. 2014, 日本分析化学会講演要旨集, 63年会, 168 - 168, Japanese

• Staining Probe for an Observation of Cell Organelle by Using Electron Microscope

  森田健太

  Lead, May 2024, 豊田研究報告, 77, 142 - 143, Japanese

  [Invited]

  Report scientific journal


• 分子の「塊」が溶連菌の感染を抑制することを発見

  森田健太, 丸山達生

  Lead, 01 May 2024, 神戸大学大学院工学研究科HP（Research Topics）


• 安価なアミノ酸を添加するだけでシート状に培養した細胞を凍結保存可能に

  森田健太, 丸山達生

  Lead, 09 Apr. 2024, 神戸大学大学院工学研究科HP（Research Topics）


• ペプチド界面活性剤（ペプチド脂質）の自己組織化とがん細胞の殺傷

  丸山達生, 森田健太

  Jan. 2024, 88(2) (2), 53 - 57, Japanese

  [Invited]

  Introduction scientific journal


• 新規機能を担う高分子の創成と活用 合成高分子の単純塗布によるプラスチック材料表面の機能化

  丸山達生, 森田健太

  30 Sep. 2023, 分離技術, 53(5) (5), 280 - 285, Japanese

  [Invited]

  Introduction scientific journal


• 過酸化チタンナノ粒子の併用による放射線増感治療法の開発

  西村 勇哉, 森田 健太, 荻野 千秋, 犬伏 祥子, 佐々木 良平, 近藤 昭彦

  日本DDS学会, May 2018, 日本DDS学会学術集会プログラム予稿集, 34回, 204 - 204, Japanese


• The Cancer Treatment Strategy with the Inorganic/Bio-Complex Nanoparticle

  NISHIMURA Yuya, MORITA Kenta, SUZUKI Takahiro, OGINO Chiaki, KONDO Akihiko

  A bio-nanocapsule (BNC) that is composed of the L protein of the hepatitis B virus (HBV) surface antigen and a lipid bilayer shows high specificity for human hepatocytes. Therefore, we have developed various specificity-altered BNCs for cancer cell types by gene engineering. While at the same time, we have demonstrated that titanium peroxide nanoparticle (TiOx) shows anticancer effect in combination with X-ray irradiation. Therefore, we tried to encapsulate the TiOx in the BNC and deliver this complex particle into the target tumor. As a result, we succeeded in demonstrating antitumor effect against mouse xenograft model with a combination of the complex particle and X-ray irradiation.

  Hosokawa Micron Corporation, 15 Dec. 2016, THE MICROMERITICS, 60(60) (60), 13 - 19, Japanese

  [Refereed][Invited]


• 3P-225 Nanoparticle-mediated cancer therapy with Xray irradiation

  Tano Atori, Morita Kenta, Ogino Chiaki, Sato Kazuyoshi, Numako Chiya, Nakayama Masao, Sasaki Ryohei, Kondo Akihiko

  日本生物工学会, 2013, 日本生物工学会大会講演要旨集, 65, 244 - 244, Japanese

• ポリアクリル酸修飾過酸化チタンナノ粒子を用いた新規放射線増感治療の開発

  森田健太

  Single work, 博士論文, Sep. 2018, Japanese


• Nanoparticle technology handbook

  Kenta Morita, Yuya Nishimura, Takahiro Suzuki, Chiaki Ogino, Akihiko Kondo

  Contributor, Application 8 - A Cancer Treatment Strategy That Combines the Use of Inorganic/Biocomplex Nanoparticles With Conventional Radiation Therapy, Elsevier, 2018, 439-443, English, ISBN: 9780444641106

  Scholarly book

  DOI

• Molecular aggregation strategy for inhibiting DNases

  Kenta Morita, Tomoko Moriwaki, Shunsuke Habe, Mariko Taniguchi-Ikeda, Tadao Hasegawa, Yusuke Minato, Takashi Aoi, Tatsuo Maruyama

  13th International Colloids Conference, Jun. 2024, English

  Poster presentation


• Molecular Co-Assembly Creates Species Selectivity in a Conventional Antifungal

  K. Morita, Y. Nishimura, J. Ishii, T. Maruyama

  Chemical Science symposium 2023: Chemistry of polymers, Oct. 2023, English

  Oral presentation


• 合成ペプチド脂質の自己組織化による選択的細胞死（菌からがん細胞まで）

  森田健太

  第4回先端膜工学研究センター成果発表会, Mar. 2023, Japanese

  [Invited]

  Invited oral presentation


• Co-assembly of a peptide amphiphile and a conventional antifungal drug creates selective toxicity to virulent fungi

  Kenta Morita, Yuya Nishimura, Jun Ishii, Tatsuo Maruyama

  The 17th pacific polymer conference (PPC17), Dec. 2022, English

  Oral presentation


• Function Control of Hydrophobic Antimicrobial Molecules by utilizing Self-Assembly of Oligopeptide-Type Low Molecular Weight Hydrogelator

  Kenta Morita, Restu Witta Kartika, Yuya Nishimura, Jun Ishii, Tatsuo Maruyama

  4th G’L’owing Polymer Symposium in KANTO (GPS-K2021), Jul. 2021, English

  Oral presentation


• Development of novel radiosensitizing cancer therapy: Combination of radiotherapy and titanium peroxide nanoparticle

  Kenta Morita, Takahiro Suzuki, Yuya Nishimura, Masao Nakayama, Ryohei Sasaki, Chiya Numako, Kazuyoshi Sato, Chiaki Ogino, Akihiko Kondo

  Pacifichem 2015, Dec. 2015, English

  Poster presentation

• 日本生物工学会

  Jan. 2022 - Present


• 高分子学会

  Jun. 2020 - Present


• 日本化学工学会

  Apr. 2017 - Present


• 日本DDS学会

  Jul. 2018 - Aug. 2019


• 日本生物工学会学生会員

  Jun. 2014 - Mar. 2017

• 分子の細胞内自己組織化によるがん選択的細胞死誘導技術の確立

  丸山 達生, 森田 健太

  日本学術振興会, 科学研究費助成事業, 基盤研究(B), 神戸大学, 01 Apr. 2024 - 31 Mar. 2026


• Induction of cancer-selective cell death by intracellular self-assembly of molecules

  丸山 達生, 森田 健太

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2023 - 31 Mar. 2026


• Selective electron staining probe for cell organelle

  森田 健太

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Kobe University, 01 Apr. 2023 - 31 Mar. 2025


• Design of amphiphilic oligopeptides that induce destructive self-assembly of pathogenic amyloids

  森田 健太

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Kobe University, 01 Apr. 2021 - 31 Mar. 2023


• A function-adjustable medical gel based on co-assembly of peptide-type gelator with various functional agents

  Morita Kenta

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up, Grant-in-Aid for Research Activity Start-up, Kobe University, 11 Sep. 2020 - 31 Mar. 2022

  The study demonstrates that the nano-assembly of a short-peptide hydrogelator (P1) imparts novel antifungal selectivity to amphotericin B (AmB), expanding its application range. AmB's limitations of poor solubility and toxicity are addressed by P1, a low-molecular-weight hydrogelator with low cytotoxicity. P1 successfully solubilizes AmB in water as micelle-like nano-complexes (NCs), reducing its toxicity against Saccharomyces cerevisiae. Protease degradation of P1 in the NCs restores AmB's antifungal activity. Moreover, high-concentration P1 forms an AmB-incorporating hydrogel (AmB-P1 gel), effectively suppressing AmB's antifungal activity. Protease-secreting Aspergillus oryzae fails to grow on the AmB-P1 gel, indicating selective fungicidal effects. Co-assembly strategies hold promise for "drug repositioning" in the medical field, particularly against protease-secreting infectious fungi.


• Assessment of polyacrylic acid-modified titanium peroxide nanoparticles as radiosensitisers

  Nakayama Masao, Akasaka Hiroaki, Morita Kenta, Alsayed Mennaallah

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2016 - 31 Mar. 2019

  Our previous studies indicated that titanium peroxide nanoparticles (TiOxNPs) induced reactive oxygen species (ROS) when expose to X-rays and enhanced radiation cytotoxic effect. In this study, the type and amount of ROS generated from TiOxNPs were investigated and compared to those generated by gold nanoparticles (GNPs). The results showed that the amount of ROS generated from TiOxNPs under X-ray irradiation was less than that of GNPs, however TiOxNPs had the ability to release H2O2 regardless of X-ray irradiation. The released H2O2 is assumed to be acted as a strong radiosensitising agent of TiOxNPs in vitro and in vivo set up. On the other hand, only 12% of the TiOxNPs dose had accumulated in the tumour 1 hour after an intravenous injection in vivo experiment. The liver had the largest accumulation of the injected nanoparticles. Future studies will be required to develop the strategies to enhance the tumour targeting ability of TiOxNPs.

• Temperature compensated surface acoustic wave device having mass loading strip with buffer layer

  TORAZAWA YUMI, FUKUHARA HIRONORI, YASHIRO YUJI, MORITA KENTA

  US-2023344408-A1, 30 Mar. 2022, SKYWORKS SOLUTIONS INC (US)

  Patent right


• Acoustic wave device having mass loading strip with buffer layer

  TORAZAWA YUMI, FUKUHARA HIRONORI, YASHIRO YUJI, MORITA KENTA

  US-2023344407-A1, 30 Mar. 2022, SKYWORKS SOLUTIONS INC (US)

  Patent right


• Acoustic wave device having mass loading strip with thermal expansion compensation buffer layer

  TORAZAWA YUMI., FUKUHARA HIRONORI., YASHIRO YUJI, MORITA KENTA

  US-2023344406-A1, 30 Mar. 2022

  Patent right