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MIYAWAKI DaisukeUniversity Hospital / Radiation OncologyAssociate Professor
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■ Paper- The expression of EGFR and p16 in the external auditory canal squamous cell carcinoma (EACSCC) and their impacts on oncological outcomes were not well studied. Seventeen-one consecutive patients who were treated for EACSCC at Kobe University Hospital from 1995 to 2018 were enrolled in this study. The expression of EGFR, and p16 were evaluated and their impacts on oncological outcomes were statistically analyzed. Positive expression of EGFR was observed in 62 patients (87%). Strong positive expression of p16 were observed in 18 patients (32.4%), and weakly positive expression in 30 patients (42.3%), respectively. While the number of the patients with negative EGFR expression were limited, all the surgically treated patients with negative EGFR expression have been alive without disease. In the patients with T3 & T4a EACSCC, prognosis of the patients with positive p16 expression EACSCC tended to be better than those with negative p16 expression. These results suggest the clinical significance of EGFR and p16 expressions in the patients with advanced EACSCC to predict oncological outcomes.Jan. 2024, The Kobe journal of medical sciences, 69(4) (4), E144-E150, English, Domestic magazineScientific journal
- BACKGROUND: Squamous cell carcinoma of the external auditory canal (EACSCC) is a rare condition. However, a standard treatment has not yet been established. We retrospectively evaluated the efficacy, adverse events, and feasibility of TPF-CCRT (concomitant chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil) in patients with advanced EACSCC. METHODS: Thirty-five consecutive patients with advanced EACSCC (T3, T4) initially treated with TPF-CCRT at Kobe University Hospital were included. T4 diseases with invasion of the brain, internal carotid artery, or internal jugular vein were classified as T4b, and those without these features were classified as T4a. RESULTS: Five-year overall survival rates for T3 and T4 were 100% and 64.2%, respectively. A significant difference was observed between T4a and T4b (82.4% vs. 30%, p = 0.007). Five-year progression-free survival rates of T3, T4a, and T4b were 100%, 68%, and 20% (p = 0.022), respectively. CONCLUSIONS: TPF-CCRT should be considered as a plausible treatment option for advanced EACSCC.Jul. 2023, Head & neck, English, International magazineScientific journal
- (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 132 - 132, Japanese当院における甲状腺がんに対するがん遺伝子パネル検査の現状と課題
- (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 152 - 152, Japanese進行頭頸部扁平上皮がん患者における静脈血栓塞栓症 前向き観察研究サブ解析
- BACKGROUND/AIM: Sarcopenia is an independent survival predictor in several tumor types. Computed tomography (CT) is the standard measurement for body composition assessment. Radiomics analysis of CT images allows for the precise evaluation of skeletal muscles. This study aimed to construct a prognostic survival model for patients with esophageal cancer who underwent radical irradiation using skeletal muscle radiomics. PATIENTS AND METHODS: We retrospectively identified patients with esophageal cancer who underwent radical irradiation at our institution between April 2008 and December 2017. Skeletal muscle radiomics were extracted from an axial pretreatment CT at the third lumbar vertebral level. The prediction model was constructed using machine learning coupled with the least absolute shrinkage and selection operator (LASSO). The predictive nomogram model comprised clinical factors with radiomic features. Three prediction models were created: clinical, radiomics, and combined. RESULTS: Ninety-eight patients with 98 esophageal cancers were enrolled in this study. The median observation period was 57.5 months (range=1-98 months). Thirty-five radiomics features were selected by LASSO analysis, and a prediction model was constructed using training and validation data. The average of the accuracy, specificity, sensitivity, and area under the concentration-time curve for predicting survival in esophageal cancer in the combined model were 75%, 92%, and 0.86, respectively. The C-indices of the clinical, radiomics, and combined models were 0.76, 0.80, and 0.88, respectively. CONCLUSION: A prediction model with skeletal muscle radiomics and clinical data might help determine survival outcomes in patients with esophageal cancer treated with radical radiotherapy.Apr. 2023, Anticancer research, 43(4) (4), 1749 - 1760, English, International magazineScientific journal
- 金原出版(株), Apr. 2022, 臨床放射線, 67(4) (4), 365 - 371, Japanese
- (公社)日本医学放射線学会, Feb. 2022, Japanese Journal of Radiology, 40(Suppl.) (Suppl.), 36 - 36, JapanesecT3N0M0声門癌に対する根治的放射線治療の成績
- Purpose: To investigate the oncological outcomes of orbital malignant tumors invading the skull base. Methods: A retrospective analysis was conducted on 16 patients with orbital malignant tumors invading the skull base. Eleven patients were treated with skull base surgery, four patients were treated with particle therapies, and one patient was treated with chemoradiotherapy (CRT) as initial treatment. Results: The most frequent histological type was adenoid cystic carcinoma in seven patients, followed by squamous cell carcinoma in two patients. Local recurrence occurred in two of the six surgically treated patients who did not receive postoperative radiotherapy (RT) or CRT. One of them was successfully salvaged by RT, and the other died of disease. With a median follow-up of 24 months, the 2-year overall, local control, and disease-free survival rates of all patients were 82.5%, 87.5%, and 59%, respectively. Conclusions: Patients with positive surgical margins were at risk of local recurrence. Postoperative RT should be considered for all surgically treated patients.Level of Evidence: 4.Dec. 2021, Laryngoscope investigative otolaryngology, 6(6) (6), 1347 - 1352, English, International magazineScientific journal
- PURPOSE: Chemoradiotherapy with docetaxel (DOC), cisplatin (CDDP), and 5-FU (TPF-CRT) for locally advanced external auditory canal cancer (EACC) has favorable oncological and functional outcomes. To establish TPF-CRT as a standard of care for advanced EACC, we conducted this study to determine the maximum tolerated (MTD) and recommended dose (RD) of DOC in TPF-CRT for locally advanced EACC. METHODS: To determine the recommended (RD) and maximum tolerated dose (MTD) of DOC in TPF-CRT for EACC, a phase I trial was conducted using the standard "3 + 3" design for maximum dose finding. DOC was administered twice every 4 weeks, CDDP at 70 mg/m2 and 5-FU at 700 mg/m2; patients were also receiving radiotherapy (66 Gy). Eight patients with T3 or T4 EACC were prospectively enrolled. RESULTS: Two patients treated with DOC, 50 mg/m2, and one out of six patients treated with DOC, 40 mg/m2, had dose-limiting toxicities. Prolonged febrile neutropenia was observed in three patients. Grade 3 non-hematological toxicities were observed in only three patients. At study completion, six patients survived, five of whom were disease free. CONCLUSION: The RD and MTD of DOC in TPF-CRT for locally advanced EACC are 40 mg/m2 when doses of CDDP and 5-FU are 70 mg/m2 and 700 mg/m2, respectively.Jul. 2021, European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 279(6) (6), 2805 - 2810, English, International magazineScientific journal
- Cambridge University Press (CUP), Apr. 2021, The Journal of Laryngology & Otology, 135(4) (4), 297 - 303
Abstract Background The prognosis of patients with advanced squamous cell carcinoma of the external auditory canal and middle ear has been improved by advances in skull base surgery and multidrug chemoradiotherapy during the last two decades.Methods Ninety-five patients with squamous cell carcinoma of the external auditory canal and middle ear who were treated between 1998 and 2017 were enrolled. The number of patients with tumour stages T1, T2, T3 and T4 was 15, 22, 24 and 34, respectively. Oncological outcomes and prognostic factors were retrospectively investigated.Results Among patients with T4 disease, invasion of the brain (p = 0.024), carotid artery (p = 0.049) and/or jugular vein (p = 0.040) were significant predictors of poor prognosis. The five-year overall survival rate of patients with at least one of these factors (T4b) was significantly lower than that of patients without these factors (T4a) (25.5vs 65.5 per cent,p = 0.049).Conclusion It is proposed that stage T4 be subclassified into T4a and T4b according to the prognostic factors.Scientific journal - Background: Skeletal related events due to metastatic bone tumors markedly affect the activities of daily living (ADL) and quality of life (QOL) in cancer patients. We focused on multidisciplinary therapy for metastatic bone tumors. This study aimed to evaluate the outcomes of surgical treatment for metastatic bone tumors in the extremities. Methods: We retrospectively reviewed 114 patients who underwent surgical treatment for metastatic bone tumors of the extremities between 2008 and 2019 and 69 patients were reassessed for more than 6 months after surgery. The most common primary tumor was renal, followed by lung, thyroid, and breast cancers. We assessed 69 patients' performance status (PS), Barthel Index (BI) for ADL, EuroQol 5 Dimensions (EQ-5D) for QOL, and numerical rating scale (NRS) for pain and analyzed these postoperative values relative to preoperative values using Friedman's test. The postoperative overall survival and the prognostic factors were evaluated using the Kaplan-Meier method, the log-rank test and Cox proportional hazards analysis. Results: The 1-year overall survival rate was 59%, and the median survival time after surgery was 20 months. Primary tumor, visceral metastasis, and surgical procedure were risk factors correlated with overall survival. PS, BI, EQ-5D, and NRS improved at 3 months after surgery and these improvements were maintained for 6 months after surgery regardless of the surgical procedure. Conclusions: The significant factors affecting survival after surgical treatment for bone metastases included the primary tumor, presence of visceral metastases, and internal fixation without tumor resection or curettage. Surgical treatment for metastatic bone tumors effectively reduced pain and improved PS, ADL, and QOL postoperatively after 3 months.Apr. 2021, Journal of bone oncology, 27, 100352 - 100352, English, International magazineScientific journal
- The precise mechanism of intercellular communication between cancer cells following radiation exposure is unclear. Exosomes are membrane‑enclosed small vesicles comprising lipid bilayers and are mediators of intercellular communication that transport a variety of intracellular components, including microRNAs (miRNAs or miRs). The present study aimed to identify novel roles of exosomes released from irradiated cells to neighboring cancer cells. In order to confirm the presence of exosomes in the human pancreatic cancer cell line MIAPaCa‑2, ultracentrifugation was performed followed by transmission electron microscopy and nanoparticle tracking analysis (NanoSight) using the exosome‑specific surface markers CD9 and CD63. Subsequent endocytosis of exosomes was confirmed by fluorescent microscopy. Cell survival following irradiation and the addition of exosomes was evaluated by colony forming assay. Expression levels of miRNAs in exosomes were then quantified by microarray analysis, while protein expression levels of Cu/Zn‑ and Mn‑superoxide dismutase (SOD1 and 2, respectively) enzymes in MIAPaCa‑2 cells were evaluated by western blotting. Results showed that the uptake of irradiated exosomes was significantly higher than that of non‑irradiated exosomes. Notably, irradiated exosomes induced higher intracellular levels of reactive oxygen species (ROS) and a higher frequency of DNA damage in MIAPaCa‑2 cells, as determined by fluorescent microscopy and immunocytochemistry, respectively. Moreover, six up‑ and five downregulated miRNAs were identified in 5 and 8 Gy‑irradiated cells using miRNA microarray analyses. Further analysis using miRNA mimics and reverse transcription‑quantitative PCR identified miR‑6823‑5p as a potential candidate to inhibit SOD1, leading to increased intracellular ROS levels and DNA damage. To the best of our knowledge, the present study is the first to demonstrate that irradiated exosomes enhance the radiation effect via increasing intracellular ROS levels in cancer cells. This contributes to improved understanding of the bystander effect of neighboring cancer cells.Apr. 2021, Oncology reports, 45(4) (4), 1 - 1, English, International magazineScientific journal
- BACKGROUND: To evaluate factors associated with osteoradionecrosis of the jaw (ORNJ) in patients with head and neck squamous cell carcinoma (HNSCC), focusing on jaw-related dose-volume histogram (DVH) parameters. METHODS: We retrospectively reviewed the medical records of 616 patients with HNSCC treated with curative-intent or postoperative radiation therapy (RT) during 2008-2018. Patient-related (age, sex, history of smoking or alcohol use, diabetes mellitus, performance status, pre-RT dental evaluation, pre- or post-RT tooth extraction), tumor-related (primary tumor site, T-stage, nodal status), and treatment-related (pre-RT surgery, pre-RT mandible surgery, induction or concurrent chemotherapy, RT technique) variables and DVH parameters (relative volumes of the jaw exposed to doses of 10 Gy-70 Gy [V10-70]) were investigated and compared between patients with and without ORNJ. The Mann-Whitney U test was used to compare RT dose parameters. Univariate and multivariate Cox regression analyses were used to assess factors associated with ORNJ development. Kaplan-Meier analyses were performed for cumulative ORNJ incidence estimation. RESULTS: Forty-six patients (7.5%) developed ORNJ. The median follow-up duration was 40 (range 3-145) months. The median time to ORNJ development was 27 (range 2-127) months. DVH analysis revealed that V30-V70 values were significantly higher in patients with than in those without ORNJ. In univariate analyses, primary tumor site, pre-RT mandible surgery, post-RT tooth extraction, and V60 > 14% were identified as important factors. In multivariate analyses, V60 > 14% (p = 0.0065) and primary tumor site (p = 0.0059) remained significant. The 3-year cumulative ORNJ incidence rates were 2.5% and 8.6% in patients with V60 ≤ 14% and > 14%, respectively (p < 0.0001), and 9.3% and 1.4% in patients with oropharyngeal or oral cancer and other cancers, respectively (p < 0.0001). CONCLUSIONS: V60 > 14% and oropharyngeal or oral cancer were found to be independent risk factors for ORNJ. These findings might be useful to minimize ORNJ incidence in HNSCC treated with curative RT.Jan. 2021, Radiation oncology (London, England), 16(1) (1), 1 - 1, English, International magazineScientific journal
- BACKGROUND/AIM: We aimed to investigate the dosimetric effects of a spacer placed between the pancreas and surrounding gastrointestinal structures in intensity-modulated radiation therapy (IMRT) planning to provide more effective radiation therapy for locally advanced pancreatic cancer (LAPC). PATIENTS AND METHODS: Treatment planning was performed for six patients with LAPC based on computed tomography images without spacers and with 5-mm or 10-mm spacers virtually inserted under the supervision of a hepatobiliary pancreatic surgeon. The prescription dose was 63 Gy in 28 fractions. RESULTS: With the exception of one case of pancreatic head cancer, planning target volume receiving ≥95% of the prescribed dose (PTV V95) was achieved by 90% or more by inserting a spacer, and by 95% or more in all 3 cases of pancreatic body and tail cancer by inserting a 10-mm spacer. CONCLUSION: IMRT with appropriate spacer placement may help provide high-dose treatment for LAPC and improve associated patient outcomes.Jan. 2021, Anticancer research, 41(1) (1), 503 - 508, English, International magazineScientific journal
- PURPOSE: To develop a novel biocompatible solid fiducial marker that prevents radiopaque imaging artifacts and also maintains high imaging contrast for kilovoltage x-ray image-guided radiation therapy. METHODS: The fiducial marker was made of pure zinc. An in-house water-equivalent phantom was designed to evaluate artifacts and visibility under various simulated treatment scenarios. Image artifacts were quantitatively assessed in terms of the metal artifact index (MAI) on kilovoltage computed tomography (CT) and cone-beam CT (CBCT) scans. Marker visibility was evaluated on two types of kilovoltage planar x-ray images in terms of the contrast-to-background ratio (CBR). Comparisons with a conventional gold fiducial marker were conducted. RESULTS: The use of zinc rather than a gold marker mitigates imaging artifacts. The MAI near the zinc marker decreased by 76, 79, and 77 % in CT, and by 77 (81), 74 (80), and 79 (85) % in CBCT full-fan (half-fan) scans, when using one-, two-, and three-marker phantom settings, respectively. The high-contrast part of the zinc marker exhibited CBRs above 2.00 for 28/32 exposures under four (lung, tissue, low-density bone, and high-density bone) different simulation scenarios, making its visibility comparable to that of the gold marker (30/32 exposures with CBRs > 2.00). CONCLUSIONS: We developed a biocompatible, artifact-robust, and highly visible solid zinc fiducial marker. Although further evaluation is needed in clinical settings, our findings suggest its feasibility and benefits for kilovoltage x-ray image-guided radiation therapy.Oct. 2020, Medical physics, 47(10) (10), 4703 - 4710, English, International magazine[Refereed]Scientific journal
- Gastrointestinal toxicity is frequently observed secondary to accidental or therapeutic radiation exposure. However, the variation in the intestinal metabolites after abdominal radiation exposure remains ambiguous. In the present study, C57BL/6 mice were exposed to 0, 2, and 20 Gy irradiation dose. The Head and chest of each mouse were covered with a lead shield before x-ray irradiation. 24 h post-irradiation treatment, intestinal tissue of each mouse was excised and prepared for metabolites measurement using gas chromatography-mass spectrometry (GC-MS). Our comprehensive analysis of metabolites in the intestinal tissues detected 44 metabolites after irradiation, including amino acids, carbohydrates, organic acids, and sugars. Amino acid levels in the intestinal tissue gradually rose, dependent on the radiation dose, perhaps as an indication of oxidative stress. Our findings raise the possibility that amino acid metabolism may be a potential target for the development of treatments to alleviate or mitigate the harmful effects of oxidative stress-related gastrointestinal toxicity due to radiation exposure.Sep. 2020, Biochemistry and biophysics reports, 23, 100789 - 100789, English, International magazineScientific journal
- The development of potentially safe radiosensitizing agents is essential to enhance the treatment outcomes of radioresistant cancers. The titanium peroxide nanoparticle (TiOxNP) was originally produced using the titanium dioxide nanoparticle, and it showed excellent reactive oxygen species (ROS) generation in response to ionizing radiation. Surface coating the TiOxNPs with polyacrylic acid (PAA) showed low toxicity to the living body and excellent radiosensitizing effect on cancer cells. Herein, we evaluated the mechanism of radiosensitization by PAA-TiOxNPs in comparison with gold nanoparticles (AuNPs) which represent high-atomic-number nanoparticles that show a radiosensitizing effect through the emission of secondary electrons. The anticancer effects of both nanoparticles were compared by induction of apoptosis, colony-forming assay, and the inhibition of tumor growth. PAA-TiOxNPs showed a significantly more radiosensitizing effect than that of AuNPs. A comparison of the types and amounts of ROS generated showed that hydrogen peroxide generation by PAA-TiOxNPs was the major factor that contributed to the nanoparticle radiosensitization. Importantly, PAA-TiOxNPs were generally nontoxic to healthy mice and caused no histological abnormalities in the liver, kidney, lung, and heart tissues.Jun. 2020, Nanomaterials (Basel, Switzerland), 10(6) (6), English, International magazineScientific journal
- We retrospectively reviewed the effect of stereotactic body radiation therapy (SBRT) in patients with stage I lung cancer whose lung tumor showed a nodular appearance of ground glass opacity, so-called ground glass nodule (GGN). A total of 84 patients (42 men, 42 women; mean age, 75 years) with stage I lung cancer with GGN accompanying a solid component <50% in diameter of the tumor and no metastases were studied. Concerning histology, 32 tumors were adenocarcinoma, 1 was squamous cell carcinoma, 2 were unclassified carcinoma and 49 cases were histology-unproven but increased in size or had a positive finding in 18F-FDG positron emission tomography (PET) examination. The median tumor size was 20 mm (range, 10-41 mm). All of the patients were treated with SBRT, and the total prescribed dose at the isocenter ranged between 48 Gy in four fractions and 84 Gy in ten fractions. Median follow-up duration was 33 months. No patient had local failure nor regional lymph node failure. The 3-year rate of distant failure was 2.6%. Two patients who experienced distant metastases had a past surgical history of initial lung cancer before SBRT. The rates of cause-specific and overall survival at 3 years were 98.2 and 94.6%, respectively. Treatment-related adverse events of ≥grade 4 were not reported. Although more cases and longer follow-ups are mandatory, SBRT may be one of the radical treatment options for patients with GGN.May 2020, Journal of radiation research, 61(3) (3), 426 - 430, English, International magazine[Refereed]Scientific journal
- OBJECTIVE: To investigate the oncological and functional outcomes of the patients treated with transoral CO2 laser cordectomy for early glottic cancer. PATIENTS AND METHODS: Fifty-five consecutive patients who underwent CO2 laser cordectomy for early glottic cancer were retrospectively reviewed. RESULTS: Overall survival, larynx preservation, and relapse free local control rates were 96%, 100%, and 91%, respectively. Five patients with local recurrences were salvaged with re-cordectomy and/or radiotherapy. In type I cordectomy, VHI-10 consistently improved during postoperative course and VHI-10 at postoperative 12months was significantly better than preoperative value (2.3 vs. 9.4, p=0.02). Perceptual grading, MPT, MFR and AC/DC also improved and were better than preoperative values. In type III cordectomy, shimmer at 12months after cordectomy was significantly better than preoperative value (14.7 vs. 9.3, p=0.007). CONCLUSIONS: These results further support the rationale of CO2 cordectomy as initial and salvage surgery for early glottic cancer.Apr. 2020, Auris, nasus, larynx, 47(2) (2), 276 - 281, English, International magazine[Refereed]Scientific journal
- Recently, the introduction of various novel technologies in clinical settings has improved the accuracy of radiation therapy. Stereotactic body radiation therapy (SBRT) involves the delivery of an accurate radiation dose to the tumor with a minimal impact on normal tissues using various measures to address changes in the tumor position due to respiratory displacement. The SyncTraX FX4 real-time tumor tracking system (Shimadzu Corporation) introduced in our hospital tracks the actual tumor location by radioscopically monitoring a metallic marker that is placed in the vicinity of the tumor. However, there have been no reports yet on respiratory-gated volumetric modulated arc therapy (VMAT)-SBRT using a real-time tumor tracking system. This study aimed to develop an irradiation procedure for respiratory-gated VMAT-SBRT using a real-time tumor tracking system and to evaluate radiation doses therein. In this study, we found that absolute doses with respiratory gating did not deviate by more than ±1.0% from those without respiratory gating. In addition, the pass rate in gamma analysis using GAFCHROMIC EBT3 was ³95% with the pass criteria in dose difference, distance to agreement, and threshold being 2%, 2 mm, and 10%, respectively. Furthermore, a trajectory log file analysis did not reveal any significant error causes. Thus, these data indicate that respiratory-gated VMAT-SBRT can be applied clinically.2020, Nihon Hoshasen Gijutsu Gakkai zasshi, 76(7) (7), 674 - 688, Japanese, Domestic magazineScientific journal
- BACKGROUND: The purpose of this study was to investigate the effectiveness of dental intervention before and after radiation therapy (RT) for head and neck malignancy on prevention of osteoradionecrosis (ORN) of the jaws. METHODS: This is a single-arm prospective study according to intervention protocol of prophylactic dental extraction before RT and routine follow-up after RT. The primary endpoint was the occurrence of jawbone exposure during the first 2 years after RT. RESULTS: Sixty-seven patients were assessed. Before RT, 144 teeth among 39 patients (58%) were prophylactically extracted. The occurrence of transient jawbone exposure during the first 2 years after RT was 7%. Because those jawbone exposures healed with intervention after RT, no jawbone exposure was found at 2 years after RT. CONCLUSIONS: Dental intervention both before and after RT seemed to be important to prevent ORN development. Further studies in larger cohorts are necessary.Sep. 2019, Oral and maxillofacial surgery, 23(3) (3), 297 - 305, English, International magazine[Refereed]Scientific journal
- (一社)日本小児血液・がん学会, Sep. 2019, 日本小児血液・がん学会雑誌, 56(2) (2), 148 - 152, Japanese放射線治療 QOLを考慮した局所治療 小児がんに対する吸収性スペーサー留置を併用した粒子線治療[Refereed]
- Elsevier {BV}, May 2019, Advances in Radiation Oncology, 4(4) (4), 729 - 737[Refereed]Scientific journal
- Elsevier BV, Apr. 2019, Advances in radiation oncology, 4(2) (2), 237 - 245, English, International magazine[Refereed]Scientific journal
- Enhancing the antitumor effect of radiation, while reducing damage to organs, is a significant challenge in radiation therapy for head and neck malignancies. One promising radiosensitizer is gold. The present study aimed to determine whether gold nanoparticles (AuNPs) have the potential to enhance the effects of X-ray irradiation on head and neck cancer cells. The human head and neck carcinoma cell line HSC-3 was used. Total cell number and the levels of cell proliferation and apoptosis were compared between control cells and cells treated with 5-nm AuNPs alone at four concentrations (0.1, 0.4, 1.0 and 10.0 nM), X-ray irradiation alone at three doses (2, 4 and 8 Gy), or a combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs. Analysis of variance and Tukey-Kramer testing were performed to compare the different groups. The total number of cells significantly decreased following 4 and 8 Gy X-ray irradiation, compared with in the control group (control vs. 4Gy, P=2.19×10-4; control vs. 8Gy, P=1.28×10-6). The combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs significantly reduced the total number of cells compared with 4 Gy X-ray irradiation alone (P=2.95×10-4). Cell proliferation was not affected by AuNP treatment alone, 4 Gy X-ray irradiation alone or the combination of X-ray irradiation and AuNPs. The combination of 4 Gy irradiation and 1.0 nM AuNPs significantly increased the number of apoptotic cells compared with 4 Gy irradiation alone (P=0.0261). In conclusion, AuNPs combined with X-ray irradiation enhanced the cytotoxic effect on human head and neck cancer cells in vitro, through the induction of apoptosis, but not inhibition of cell proliferation.Nov. 2018, Biomedical reports, 9(5) (5), 415 - 420, English, International magazine[Refereed]Scientific journal
- This study aimed to compare dosimetric parameters between non-optimized and optimized treatment planning (NOP and OP, respectively) of magnetic resonance imaging (MRI) -based intracavitary (IC) image-guided adaptive brachytherapy (IGABT) using the central shielding (CS) technique for cervical cancer. Fifty-three patients treated with external beam radiotherapy using CS and MRI-based IGABT with the IC approach alone were evaluated. The total high-risk clinical target volume (HR-CTV) D90 was aimed at >70 Gy equivalent dose in 2 Gy fractions (EQD2). In the small HR-CTV group (≤30 cm3), the mean D90s for NOP/OP were 98.6/80.7 Gy. In the large (30.1-40 cm3) and extensive (>40 cm3) HR-CTV groups, the mean D90s were 81.9/77.5 and 71.1/73.6 Gy, respectively. The mean D2cc values for organs at risks (OARs) in OP were acceptable in all groups, despite the high bladder D2cc in the NOP. The correlation between HR-CTV at first brachytherapy (BT) and NOP D90 was stronger than that between HR-CTV at first BT and OP D90. The targeted HR-CTV D90 and dose constraints of D2cc for OARs were both achieved in 16 NOP/47 OP patients for the bladder, 39/50 for the rectum, and 47/50 for the sigmoid colon (P < 0.001, P = 0.007, and P = 0.34, respectively). For small tumors, the role of optimization was to reduce the D2cc for OARs while maintaining the targeted D90. However, optimization was of limited value for extensive tumors. Methods of optimization in IGABT with CS for cervical cancer should be standardized while considering its effectiveness and limitations.May 2018, Journal of radiation research, 59(3) (3), 316 - 326, English, International magazine[Refereed]Scientific journal
- (一社)日本頭頸部癌学会, May 2018, 頭頸部癌, 44(2) (2), 176 - 176, Japanese甲状腺癌気道浸潤例に対する放射線外照射の有効性の検討Research society
- (公社)日本医学放射線学会, Feb. 2018, Japanese Journal of Radiology, 36(Suppl.) (Suppl.), 36 - 36, Japanese当院における子宮頸部腺癌の根治的放射線治療の治療成績の検討
- (公社)日本医学放射線学会, Feb. 2018, Japanese Journal of Radiology, 36(Suppl.) (Suppl.), 31 - 31, Japanese子宮頸癌化学放射線療法中のADC値の変化に関する検討 治療前と腔内照射直前の比較
- Jan. 2018, The Kobe journal of medical sciences, 63(3) (3), E84-E91 - E91, English, Domestic magazineEvaluation of a Small Animal Irradiation System for Animal Experiments Using EBT3 Model GAFCHROMIC™ Film.[Refereed]Scientific journal
- The objective of the present study was the determination of the potential dosimetric benefits of using metal-artefact-suppressed dual-energy computed tomography (DECT) images for cases involving pedicle screw implants in spinal sites. A heterogeneous spinal phantom was designed for the investigation of the dosimetric effect of the pedicle-screw-related artefacts. The dosimetric comparisons were first performed using a conventional two-directional opposed (AP-PA) plan, and then a volumetric modulated arc therapy (VMAT) plan, which are both used for the treatment of spinal metastases in our institution. The results of Acuros® XB dose-to-medium (Dm) and dose-to-water (Dw) calculations using different imaging options were compared with experimental measurements including the chamber and film dosimetries in the spinal phantom. A dual-energy composition image with a weight factor of -0.2 and a dual-energy monochromatic image (DEMI) with an energy level of 180 keV were found to have superior abilities for artefact suppression. The Dm calculations revealed greater dosimetric effects of the pedicle screw-related artefacts compared to the Dw calculations. The results of conventional single-energy computed tomography showed that, although the pedicle screws were made from low-Z titanium alloy, the metal artefacts still have dosimetric effects, namely, an average (maximum) Dm error of 4.4% (5.6%) inside the spinal cord for a complex VMAT treatment plan. Our findings indicate that metal-artefact suppression using the proposed DECT (DEMI) approach is promising for improving the dosimetric accuracy near the implants and inside the spinal cord (average (maximum) Dm error of 1.1% (2.0%)).Jul. 2017, Physics in medicine and biology, 62(15) (15), 6226 - 6245, English, International magazine[Refereed]Scientific journal
- AIM: To evaluate the treatment results of radiotherapy (RT) in children and adults with brainstem gliomas (BSGs) and review the previous literature. METHODS: Thirty patients (14 children, 16 adults) with BSG treated using RT were retrospectively evaluated. The median ages of the children and adults were 8 years (range: 2-16 years) and 49 years (range: 19-75 years), respectively. A histological diagnosis was obtained in 11 patients. The median total radiation dose was 56 Gy (range: 50-70 Gy) with a single fraction size of 1.8-2.0 Gy. Temozolomide was administered concurrently with RT in 14 patients. RESULTS: Tumor progression after RT occurred in 26 patients (14 children and 12 adults). Four adults survived without tumor progression. The median survival times for children and adults were 8.5 and 39 months, respectively. The 1-, 2- and 3-year overall survival rates for children/adults were 29%/75%, 14%/68% and 0%/53%, respectively (P = 0.001), and the 1-, 2- and 3-year progression-free survival rates for children/adults were 14%/69%, 0%/49% and 0%/35%, respectively (P < 0.001). Grade 3 or higher acute and late toxicities did not occur. CONCLUSION: In this study, the prognosis of children with BSGs was considerably poorer than that of adults, and our results are consistent with those of previous studies. Efforts should be made to improve the survival outcomes of patients with BSGs, especially children.Apr. 2017, Asia-Pacific journal of clinical oncology, 13(2) (2), e153-e160, English, International magazine[Refereed]Scientific journal
- (公社)日本医学放射線学会, Feb. 2017, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 41 - 41, Japanese鼻腔腫瘍に対する放射線治療の経験
- (公社)日本医学放射線学会, Feb. 2017, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 50 - 50, Japanese80歳以上の子宮頸癌患者に対する放射線治療の経験
- 2017, Kobe Journal of Medical Sciences (Web), 63(3) (3), E84‐E91 (WEB ONLY), EnglishEvaluation of a Small Animal Irradiation System for Animal Experiments Using EBT3 Model GAFCHROMIC Film
- (一社)日本がん看護学会, Jan. 2017, 日本がん看護学会誌, 31(Suppl.) (Suppl.), 266 - 266, Japanese放射線療法後の乳がんハンドブック作成の意義と評価 多施設共同による乳がん放射線療法後の患者サポートの試み
- Jan. 2017, Journal of radiation research, 58(1) (1), 17 - 23, English, International magazine[Refereed]Scientific journal
- Efficacy of stereotactic body radiotherapy for hepatocellular carcinoma with portal vein tumor thrombosis/inferior vena cava tumor thrombosis: evaluation by comparison with conventional three-dimensional conformal radiotherapy.This study aimed to evaluate the efficacy of stereotactic body radiotherapy (SBRT) compared with three-dimensional conformal radiotherapy (3DCRT). Forty-three patients with portal vein tumor thrombosis (PVTT)/inferior vena cava tumor thrombosis (IVCTT) treated with SBRT (27 with CyberKnife (CK) and 16 with TrueBeam (TB)) from April 2013 to December 2014, and 54 treated with 3DCRT from June 2008 to March 2013 were evaluated. Dosimetric parameters, response to radiotherapy (RT) and survival outcomes were compared in total SBRT vs. 3DCRT, CK vs. 3DCRT and TB vs. 3DCRT, respectively. The median biologically effective dose 10 (BED10) values in total SBRT, CK, TB and 3DCRT were 73.4 Gy10, 75.0 Gy10, 60.5 Gy10 and 58.5 Gy10, respectively (P < 0.001 in total SBRT vs. 3DCRT, P < 0.001 in CK vs. 3DCRT, P = 0.004 in TB vs. 3DCRT). The tumor response rates were 67%, 70%, 62% and 46%, respectively (P = 0.04, P = 0.04, P = 0.25). The 1-year overall survival rates were 49.3%, 56.7%, 38.1% and 29.3%, respectively (P = 0.02, P = 0.02, P = 0.30), and the 1-year local progression rates were 20.4%, 21.9%, 18.8% and 43.6%, respectively (P = 0.01, P = 0.04, P = 0.10). The use of SBRT made it possible to achieve a higher BED10 compared with the use of 3DCRT. Improvements in local control and survival were achieved in the CK group and the total SBRT group. Our results suggest that SBRT may have the potential to be the standard RT technique for the treatment of PVTT/IVCTT.Sep. 2016, Journal of radiation research, 57(5) (5), 512 - 523, English, International magazine[Refereed]Scientific journal
- (公社)日本婦人科腫瘍学会, Jun. 2016, 日本婦人科腫瘍学会雑誌, 34(3) (3), 494 - 494, Japanese子宮頸癌に対するMRIガイド下画像誘導小線源治療の初期経験[Refereed]
- Jun. 2016, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 192(6) (6), 386 - 93, English, International magazine[Refereed]Scientific journal
- May 2016, Nihon rinsho. Japanese journal of clinical medicine, 74 Suppl 3, 503 - 507[Radiotherapy with androgen deprivation for localized prostate cancer].[Refereed]
- (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2) (2), 207 - 207, Japanese鼻腔腫瘍に対する放射線治療の経験[Refereed]
- (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2) (2), 207 - 207, Japanese舌癌術後再発症例に対する放射線治療成績[Refereed]
- Apr. 2016, 日本泌尿器科学会総会 104回, PP3 - 298, Japanese当院における前立腺癌に対する強度変調放射線療法(IMRT)の治療成績Research society
- (公社)日本医学放射線学会, Feb. 2016, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 54 - 54, Japanese乳癌経過中に癌性髄膜炎との鑑別に苦慮したクリプトコッカス髄膜炎の1例[Refereed]
- (公社)日本医学放射線学会, Feb. 2016, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 54 - 54, Japanese限局性前立腺癌に対する永久刺入小線源単独治療の経験[Refereed]
- (公社)日本医学放射線学会, Feb. 2016, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 44 - 44, Japanese眼瞼周囲皮膚癌に対する新規眼球シールド使用時の線量分布の検討[Refereed]
- (一社)日本癌治療学会, Sep. 2015, 日本癌治療学会誌, 50(3) (3), 2369 - 2369, Japanese鎖骨上・縦隔孤発性リンパ節転移に対するサイバーナイフによる定位放射線治療
- (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 136 - 136, Englishプラチナ薬剤抵抗性の頭頸部がんに関する炎症スコアの予後的な意義(Prognostic Value of the Inflammation Scores for Platinum Refractory Head and Neck Cancer)
- (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 254 - 254, Japanese中・下咽頭後壁癌に対する放射線治療成績[Refereed]
- (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 254 - 254, Japanese食道癌同時合併中下咽頭癌に対する放射線治療の経験[Refereed]
- (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 267 - 267, Japanese再発頭頸部腫瘍に対するサイバーナイフによる救済治療の初期経験
- (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 262 - 262, Japanese原発不明癌頸部リンパ節転移に対する放射線治療の経験[Refereed]
- (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 266 - 266, JapaneseN3頸部リンパ節転移症例に対する放射線治療の経験[Refereed]
- (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 207 - 207, JapaneseFlattening Filter Freeビームを用いた頭頸部VMATの検討 TomoTherapyとの比較
- (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 266 - 266, JapaneseFlattening Filter Freeビームを用いた頭頸部VMATの検討 Flattening Filter装填ビームとの比較
- Mar. 2015, Japanese journal of clinical oncology, 45(3) (3), 248 - 55, English, International magazine[Refereed]Scientific journal
- (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 70 - 70, Japanese鼻腔・副鼻腔腫瘍の治療計画における不均質補正の影響[Refereed]
- (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 64 - 64, Japanese特発性眼窩炎症に対する放射線治療経験[Refereed]Scientific journal
- (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 70 - 70, Japanese頭頸部傍神経節腫に対する放射線治療の経験[Refereed]
- (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 76 - 76, Japanese頭頸部癌に対するセツキシマブ併用放射線治療の初期経験[Refereed]
- (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 71 - 71, Japanese前立腺全摘術後のPSA再発に対する救済放射線治療の検討[Refereed]
- (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 64 - 64, Japanese成人型頭蓋外血管腫・血管奇形の放射線治療Research society
- (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 64 - 64, Japanese若年者のgliomaに対する放射線治療の経験[Refereed]Scientific journal
- (一社)日本がん看護学会, Jan. 2015, 日本がん看護学会誌, 29(Suppl.) (Suppl.), 188 - 188, Japanese多施設共同による放射線療法後の患者サポートの試み
- Dec. 2014, International journal of radiation oncology, biology, physics, 90(5) (5), 1177 - 85, English, International magazine[Refereed]Scientific journal
- Springer Tokyo, Oct. 2014, International Journal of Clinical Oncology, 19(5) (5), 963 - 971, English[Refereed]Scientific journal
- (一社)日本放射線看護学会, Aug. 2014, 日本放射線看護学会学術集会講演集 3回, 3回, 98 - 98, Japanese多職種で取り組む放射線治療に関連した研修会立ち上げの実践報告と今後の課題
- (一社)日本癌治療学会, Jun. 2014, 日本癌治療学会誌, 49(3) (3), 2659 - 2659, Japanese小線源療法後の下部尿路症状に対するシロドシンの予防効果を検討する無作為化比較試験
- (一社)日本癌治療学会, Jun. 2014, 日本癌治療学会誌, 49(3) (3), 2700 - 2700, JapaneseサイバーナイフVSIによる体幹部定位放射線治療
- (一社)日本癌治療学会, Jun. 2014, 日本癌治療学会誌, 49(3) (3), 1069 - 1069, JapaneseサイバーナイフVSIによるマーカーレス肺腫瘍動体追尾照射
- (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 265 - 265, Japanese頭頸部癌に対するセツキシマブ併用放射線治療の初期経験
- (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 238 - 238, Japanese中咽頭癌に対する化学放射線療法におけるPEG留置患者の栄養投与量と有害事象
- (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 264 - 264, Japanese上顎洞扁平上皮癌に対する放射線治療成績
- (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 155 - 155, JapaneseT3N0-1声門癌に対する喉頭温存を目的とした根治的化学放射線治療の検討
- (公社)日本医学放射線学会, Feb. 2014, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 30 - 30, Japanese脳幹部腫瘍に対する放射線治療の経験
- (公社)日本医学放射線学会, Feb. 2014, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 36 - 36, Japanese喉頭原発悪性リンパ腫に対する放射線治療の経験
- (公社)日本医学放射線学会, Feb. 2014, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 37 - 37, Japanese過酸化チタンナノ粒子による放射線増感の検討
- (公社)日本医学放射線学会, Feb. 2014, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 42 - 42, JapaneseHIV陽性患者に発生した悪性腫瘍に対する放射線治療の経験
- The present study aimed to investigate the effect of heterogeneity correction (HC) on dosimetric parameters in 3-dimensional conformal radiotherapy planning for patients with thoracic esophageal cancer. We retrospectively analyzed 20 patients. Two treatment plans were generated for each patient using a superposition algorithm on the Xio radiotherapy planning system. The first plan was calculated without HC. The second was a new plan calculated with HC, using identical beam geometries and maintaining the same number of monitor units as the first. With regard to the planning target volume (PTV), the overall mean differences in the prescription dose, maximum dose, mean dose, and dose that covers 95% of the PTV between the first and second plans were 1.10Gy (1.8%), 1.35Gy (2.2%), 1.10Gy (1.9%), and 0.56Gy (1.0%), respectively. With regard to parameters related to the organs at risk (OARs), the mean differences in the absolute percentages of lung volume receiving greater than 5, 10, 20, and 30Gy (lung V5, V10, V20, and V30) between the first and second plans were 7.1%, 2.7%, 0.4%, and 0.5%, respectively. These results suggest that HC might have a more pronounced effect on the percentages of lung volume receiving lower doses (e.g., V5 and V10) than on the dosimetric parameters related to the PTV and other OARs.2014, Medical dosimetry : official journal of the American Association of Medical Dosimetrists, 39(1) (1), 31 - 3, English, International magazine[Refereed]Scientific journal
- 2014, PloS one, 9(5) (5), e96999, English, International magazine[Refereed]Scientific journal
- [The effect of strontium-89 therapy in a patient with cholangiocellular carcinoma].A 77-year-old man was diagnosed as having cholangiocellular carcinoma. The patient underwent partial right hepatectomy in June 2008, and multiple bone metastases occurred approximately 9 months after surgery. He refused salvage chemotherapy and radiation therapy. Although he had been treated with opiate analgesics, he was unable to sit up owing to severe pain in the left ilium. He was hospitalized because of buttock pain and left leg numbness. Even a combination of fentanyl patch, gabapentin, and subarachnoid block was ineffective in controlling pain. Strontium-89 (89Sr) therapy was successful in eliminating the intractable pain, and there were no serious side effects during therapy. The patient was discharged from the hospital, and he received palliative care at home for a short period.Nov. 2013, Gan to kagaku ryoho. Cancer & chemotherapy, 40(12) (12), 1856 - 8, Japanese, Domestic magazine[Refereed]
- Nov. 2013, 癌と化学療法, 40(12号) (12号), 1856 - 1858, Japanese塩化ストロンチウム89SrCl2(メタストロン注)治療において転移性骨腫瘍に様々な抗腫瘍効果を呈した胆管細胞癌の1例[Refereed]Scientific journal
- May 2013, 日本放射線技術学会雑誌, 69(5号) (5号), 491 - 499, Japanese放射線治療計画装置を用いたkV-CBCT吸収線量評価 前立腺がん放射線治療に及ぼす影響[Refereed]Scientific journal
- [Evaluation of absorbed dose from kilovoltage cone-beam computed tomography by radiotherapy planning system: influence on the radiation therapy for prostate cancer].Image-guided radiation therapy (IGRT) is increasingly being used in modern radiation therapy, and it is now possible to verify a patient's position using kilo-voltage cone-beam computed tomography (kV-CBCT). However, if kV-CBCT is used frequently, the dose absorbed by the body cannot be disregarded. A number of studies have been made on the absorbed dose of kV-CBCT, in which absorbed dose measurements were made using a computed tomography dose index (CTDI) or a thermoluminescent dosimeter (TLD). Other methods include comparison of the absorbed dose between a kV-CBCT and other modalities. These techniques are now in common use. However, dose distribution within the patient varies with the patient's size, posture and the part of the body to which radiation therapy is applied. The chief purpose of this study was to evaluate the dose distribution of kV-CBCT by employing a radiotherapy planning system (RTPS); a secondary aim was to examine the influence of a dose of kV-CBCT radiation when used to treat prostate cancer. The beam data of an on-board imager (OBI) was registered in the RTPS, after which modeling was performed. The radiation dosimetry was arranged by the dosimeter in an elliptical phantom. Rotational radiation treatment was used to obtain the dose distribution of the kV-CBCT within the patient, and the patient dose was evaluated based on the simulation of the dose distribution. In radiation therapy for prostate cancer, if kV-CBCT was applied daily, the dose increment within the planning target volume (PTV) and the organ in question was about 1 Gy.May 2013, Nihon Hoshasen Gijutsu Gakkai zasshi, 69(5) (5), 491 - 9, Japanese, Domestic magazine[Refereed]Scientific journal
- (公社)日本医学放射線学会, Feb. 2013, 日本医学放射線学会学術集会抄録集, 72回(72回) (72回), S402 - S402, Japanese鼻腔原発NK/T細胞リンパ腫に対する放射線治療経験[Refereed]
- (公社)日本医学放射線学会, Feb. 2013, Japanese Journal of Radiology, 31(Suppl.I) (Suppl.I), 47 - 47, Japanese頭頸部腺様嚢胞癌に対する放射線治療の経験[Refereed]
- (公社)日本医学放射線学会, Feb. 2013, 日本医学放射線学会学術集会抄録集, 72回(72回) (72回), S379 - S380, Japanese成人型頭蓋外血管腫・血管奇形に対する放射線治療の経験[Refereed]
- (公社)日本医学放射線学会, Feb. 2013, Japanese Journal of Radiology, 31(Suppl.I) (Suppl.I), 51 - 51, Japanese局所進行食道癌に対する化学放射線治療[Refereed]
- 放射線療法は,切除可能膵がんに対しては術後の補助療法として有用との報告があり,切除不能進行膵がんに対して化学放射線療法の有用性が広く研究されている.5-FU併用の化学放射線療法が標準とされるが,近年,膵がんにはゲムシタビン塩酸塩やS-1が奏効すると報告されている背景からも,将来的にはゲムシタビン塩酸塩やS-1併用の化学放射線療法が主体となる可能性が高い.放射線治療計画では胃,十二指腸などの周囲臓器や腎臓,脊髄の線量を十分に検討することが必要であり,より線量集中性のよいIMRTなどの高精度放射線治療を活用し,化学療法の利点をうまく融合した,より治療効果比の高い併用療法が開発されることが期待される.The Japanese Society of Gastroenterology, 2013, Nippon Shokakibyo Gakkai Zasshi, 110(12) (12), 2073 - 2080, Japanese
- Nov. 2012, Journal of radiation research, 53(6) (6), 892 - 9, English, International magazine[Refereed]Scientific journal
- Oct. 2012, 肺癌, 52(5号) (5号), 523, Japanese小型肺結節影の診断と治療 画像診断、病理、予後 すりガラス影(GGO)を呈する肺結節95症例に対する定位放射線治療成績[Refereed]Symposium
- Jun. 2012, Radiation oncology (London, England), 7, 104 - 104, English, International magazine[Refereed]Scientific journal
- (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 244 - 244, Japanese鼻腔悪性黒色腫に対する大線量小分割法放射線治療の経験[Refereed]
- (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 195 - 195, Japanese当院における中咽頭扁平上皮癌に対する放射線治療成績[Refereed]
- (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 248 - 248, Japanese高齢頭頸部癌患者に対する放射線治療の経験 10年間の検討[Refereed]
- (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 221 - 221, Japanese顔面・頭頸部に発生した血管原性腫瘍に対する放射線治療の経験[Refereed]
- (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 267 - 267, Japanese顎下腺癌に対する放射線療法の経験[Refereed]
- (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 191 - 191, JapaneseT1-T3N0声門癌の喉頭温存を目指した治療方針の検討[Refereed]
- (公社)日本医学放射線学会, Feb. 2012, 日本医学放射線学会学術集会抄録集, 71回(71回) (71回), S337 - S337, Japanese脳幹部Gliomaに対する放射線治療の経験[Refereed]Research society
- (公社)日本医学放射線学会, Feb. 2012, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 51 - 51, Japanese当院における食道癌に対する化学放射線治療の遡及的検討[Refereed]
- (公社)日本医学放射線学会, Feb. 2012, 日本医学放射線学会学術集会抄録集, 71回(71回) (71回), S220 - S221, Japanese転移性肺腫瘍に対する粒子線治療成績の検討[Refereed]
- (公社)日本医学放射線学会, Feb. 2012, 日本医学放射線学会学術集会抄録集, 71回(71回) (71回), S314 - S314, Japanese耳下腺癌術後症例に対する放射線療法の経験[Refereed]
- (公社)日本医学放射線学会, Feb. 2012, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 39 - 39, Japanese骨転移痛に対するストロンチウム-89の初期使用経験[Refereed]
- (公社)日本医学放射線学会, Feb. 2012, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 39 - 39, Japanese胸部食道癌の治療計画における不均質補正の影響[Refereed]
- (公社)日本医学放射線学会, Feb. 2012, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 45 - 45, Japanese眼付属器MALTリンパ腫の放射線治療成績の検討[Refereed]
- (公社)日本医学放射線学会, Feb. 2012, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 45 - 45, Japanese拡散テンソル画像を用いた悪性グリオーマに対する強度変調放射線治療の検討[Refereed]
- (公社)日本医学放射線学会, Feb. 2012, 日本医学放射線学会学術集会抄録集, 71回(71回) (71回), S190 - S190, JapaneseT1-T3N0声門癌の喉頭温存を目指した治療方針の検討[Refereed]
- (公社)日本医学放射線学会, Feb. 2012, 日本医学放射線学会学術集会抄録集, 71回(71回) (71回), S220 - S220, JapaneseGGO症例に対する定位放射線治療の治療成績(多施設研究)[Refereed]Symposium
- Nov. 2011, Cancer, 117(21) (21), 4890 - 904, English, International magazine[Refereed]Scientific journal
- Oct. 2011, Archives of gynecology and obstetrics, 284(4) (4), 1007 - 14, English, International magazine[Refereed]Scientific journal
- (一社)日本癌治療学会, Sep. 2011, 頭頸部癌, 46(2) (2), 786 - 786, Japanese上顎洞扁平上皮癌に対する放射線治療成績[Refereed]
- (一社)日本癌治療学会, Sep. 2011, 日本癌治療学会誌, 46(2) (2), 884 - 884, Japanese脳幹部腫瘍に対する放射線治療の経験[Refereed]
- (一社)日本癌治療学会, Sep. 2011, 日本癌治療学会誌, 46(2) (2), 734 - 734, Japanese精巣腫瘍(seminoma)に対する放射線治療の経験[Refereed]
- (NPO)日本食道学会, Sep. 2011, 日本食道学会学術集会プログラム・抄録集65回, 65回, 323 - 323, Japanese局所進行切除不能食道癌(T4/M1LYM)に対する化学放射線療法の遡及的検討[Refereed]
- Jul. 2011, Journal of gastroenterology, 46(7) (7), 913 - 20, English, Domestic magazine[Refereed]Scientific journal
- (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 257 - 257, Japanese遊離空腸再建後の高リスク頭頸部癌に対する術後放射線治療の検討[Refereed]
- (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 228 - 228, Japanese頭頸部皮膚血管肉腫に対するRecursive partitioning analysis(RPA)の検討[Refereed]
- May 2011, 頭頸部癌, 37(2号) (2号), 215, Japanese頭頸部腺様嚢胞癌に対する粒子線(陽子線・炭素線)単独治療成績Research society
- (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 219 - 219, Japanese頭蓋底浸潤を認めた頭頸部癌に対する粒子線治療成績[Refereed]
- (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 245 - 245, Japanese当科における顎下腺癌手術症例の検討[Refereed]
- (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 303 - 303, Japanese耳下腺癌術後症例に対する放射線治療の経験[Refereed]
- (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 320 - 320, Japanese局所進行外耳道扁平上皮癌に対する3剤(TPF)併用化学放射線療法の経験[Refereed]
- (一社)日本頭頸部癌学会, Apr. 2011, 頭頸部癌, 37(1) (1), 62 - 66, Japanese[Refereed]
- (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S349 - S350, Japanese鼻腔NK/T細胞性リンパ腫に対する放射線治療の経験[Refereed]
- (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S373 - S373, Japanese精巣腫瘍(seminoma)に対する放射線治療の経験[Refereed]
- (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S354 - S354, Japanese原発不明癌頸部リンパ節転移に対する治療経験
- (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S353 - S353, Japanese局所進行外耳道扁平上皮癌に対する3剤(TPF)併用化学放射線療法の経験[Refereed]
- (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S297 - S297, Japanese1・2期下咽頭癌に対する放射線治療成績の検討[Refereed]
- 2011, APPLICATION OF ACCELERATORS IN RESEARCH AND INDUSTRY: TWENTY-FIRST INTERNATIONAL CONFERENCE, 1336, 374 - 376, English[Refereed]International conference proceedings
- Jan. 2011, Japanese Journal of Radiology, 29(Suppl.I) (Suppl.I), 43, Japanese臨床的肺癌に対する粒子線治療Research society
- Jan. 2011, Japanese Journal of Radiology, 29(Suppl.I) (Suppl.I), 48, Japanese門脈腫瘍栓(Vp3、Vp4)かつ多発肝内転移を伴う肝細胞癌に対する動注化学療法同時併用粒子線治療の初期経験Research society
- Jan. 2011, Japanese Journal of Radiology, 29(Suppl.I) (Suppl.I), 55, Japanese鼻外突出型巨大鼻腔腫瘍に対する粒子線治療経験Research society
- (公社)日本医学放射線学会, Jan. 2011, Japanese Journal of Radiology, 29(Suppl.I) (Suppl.I), 55 - 55, Japanese当院における中枢神経原発悪性リンパ腫に対する放射線治療の遡及的検討[Refereed]
- (公社)日本医学放射線学会, Jan. 2011, Japanese Journal of Radiology, 29(Suppl.I) (Suppl.I), 48 - 48, Japanese限局型小細胞肺癌に対する化学放射線療法の治療成績[Refereed]
- 2011, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81(2) (2), S630 - S630, EnglishLong-term Outcome and Patterns of Failure in Primary Ocular Adnexal MALT Lymphoma Treated with Radiotherapy[Refereed]Scientific journal
- Vitamin K2-derived compounds induce growth inhibition in radioresistant cancer cells.A strategy to overcome radioresistance in cancer treatment has been expected. To evaluate the strategy, appropriate experimental models are needed. Radioresistant tumour models were originally established from human colon cancer cells, and we evaluated their molecular basis. Next, the growth inhibitory effects of newly synthesized vitamin K2 (VK2)-related compounds were tested. Here, we showed that these novel compounds have growth inhibitory effects not only on cancer cells of various origins, but also on radioresistant cells, through the generation of reactive oxygen species (ROS). Human colon, lung, and breast cancer cell lines were used for testing the growth inhibitory activities of several chemical compounds. Radioresistant tumour models were established by fractionated radiation exposure. Irradiated cells were selected by a single cell cloning method, and their sensitivity to ionizing radiation was evaluated by a colony-forming assay. The VK2 derivatives (named MQ-1, MQ-2, and MQ-3) were chemically synthesized. To evaluate the generation of ROS, flow cytometer analyses were performed. A radioresistant tumour model was established from the HCT116 human colon cancer cell line. The radioresistant cells from HCT116 also showed resistance to cisplatin. In the radioresistant cells, NF-κB was highly activated. MQ-1, MQ-2, and MQ-3 showed greater growth inhibitory activities than VK2 not only in various cancer cells but also in radioresistant cells through the generation of ROS. In conclusion, a radioresistant tumour model was originally established from colon cancer cell lines through NF-κB activation, and it could be a useful tool for evaluating anti-tumour agents. Newly synthesized VK2 derivatives (MQ-1, MQ-2 and MQ-3) seemed to be potential anti-tumour agents in various cancers and radioresistant cancers. The efficacy of those compounds was related to the generation of ROS. These findings together might pave the way for the treatment of radioresistant or recurrent cancers.Sep. 2010, The Kobe journal of medical sciences, 56(2) (2), E38-49, English, Domestic magazineScientific journal
- (一社)日本癌治療学会, Sep. 2010, 日本癌治療学会誌, 45(2) (2), 1044 - 1044, Japanese1/2期子宮頸癌に対する根治的放射線治療の遡及的解析[Refereed]
- Jul. 2010, Japanese Journal of Radiology, 28(Suppl.I) (Suppl.I), 50, Japanese転移性肝腫瘍に対する粒子線治療Research society
- Jul. 2010, Japanese Journal of Radiology, 28(Suppl.I) (Suppl.I), 44, JapaneseT3-T4肺癌に対する粒子線治療の可能性Research society
- (公社)日本婦人科腫瘍学会, Jun. 2010, 日本婦人科腫瘍学会雑誌, 28(3) (3), 290 - 290, Japanese1/2期子宮頸癌に対する根治的放射線治療の遡及的解析[Refereed]
- (一社)日本頭頸部癌学会, May 2010, 頭頸部癌, 36(2) (2), 178 - 178, Japanese嗅神経芽細胞腫に対する粒子線治療成績[Refereed]
- (一社)日本頭頸部癌学会, May 2010, 頭頸部癌, 36(2) (2), 256 - 256, Japanese放射線治療が施行された喉頭悪性リンパ腫の3例[Refereed]
- (一社)日本頭頸部癌学会, May 2010, 頭頸部癌, 36(2) (2), 249 - 249, Japanese当院に於ける中咽頭癌の放射線治療成績[Refereed]
- (一社)日本頭頸部癌学会, May 2010, 頭頸部癌, 36(2) (2), 215 - 215, Japanese当院における頭頸部腺様嚢胞腺癌に対する術後放射線治療の遡及的検討[Refereed]
- (一社)日本頭頸部癌学会, May 2010, 頭頸部癌, 36(2) (2), 179 - 179, Japanese原発不明癌頸部リンパ節転移に対する治療経験[Refereed]
- May 2010, 頭頸部癌, 36(2号) (2号), 178, Japanese局所進行上顎洞扁平上皮癌に対する粒子線(陽子線・炭素線)治療Research society
- (一社)日本頭頸部癌学会, May 2010, 頭頸部癌, 36(2) (2), 211 - 211, Japanese下咽頭癌に対する術後放射線治療の遡及的検討[Refereed]
- May 2010, CANCER, 116(10) (10), 2476 - 2485, EnglishScientific journal
- (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 69回, S266 - S266, Japanese放射線治療が施行された喉頭悪性リンパ腫の3例[Refereed]
- Feb. 2010, 日本医学放射線学会学術集会抄録集, (69回) (69回), S370, Japanese鼻外突出型巨大鼻腔腫瘍に対する粒子線治療経験Research society
- (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 69回, S322 - S322, Japanese頭蓋内germ cell tumorに対する放射線治療成績[Refereed]International conference proceedings
- (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 69回, S268 - S268, Japanese頭蓋底脊索腫に対する粒子線治療[Refereed]
- (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 69回, S323 - S323, Japanese当院における中枢神経原発悪性リンパ腫に対する放射線治療の遡及的検討[Refereed]
- (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 69回, S361 - S361, Japanese高齢子宮頸癌患者に対する放射線治療の経験[Refereed]
- (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 69回, S372 - S372, Japanese局所進行下咽頭癌に対する術後照射の遡及的検討[Refereed]
- Feb. 2010, 日本医学放射線学会学術集会抄録集, (69回) (69回), S195, Japanese肝細胞癌に対する粒子線治療前TACEの有効性の検討Research society
- Jan. 2010, 加古川市民病院誌, (10号) (10号), 27 - 29, Japanese前立腺癌放射線治療におけるKv-CBCTを用いたorgan motionの検討[Refereed]Scientific journal
- Dec. 2009, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75(5) (5), 1487 - 1492, English[Refereed]Scientific journal
- Oct. 2009, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75(2) (2), 580 - 586, English[Refereed]Scientific journal
- Oct. 2009, International journal of radiation oncology, biology, physics, 75(2) (2), 378 - 84, English, International magazine[Refereed]Scientific journal
- THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, Sep. 2009, 日本癌治療学会誌, 44巻, 2号, pp. 532-532(4) (4), 833 - 834, Japanese[Refereed]International conference proceedings
- (一社)日本癌治療学会, Sep. 2009, 日本癌治療学会誌, 44(2) (2), 532 - 532, Japanese頭蓋底脊索腫に対する粒子線治療[Refereed]
- (一社)日本癌治療学会, Sep. 2009, 日本癌治療学会誌, 44(2) (2), 798 - 798, Japanese聴器扁平上皮癌に対する治療経験[Refereed]
- (一社)日本頭頸部癌学会, May 2009, 頭頸部癌, 35(2) (2), 145 - 145, Japanese鼻副鼻腔未分化癌10症例の粒子線治療成績[Refereed]
- May 2009, 頭頸部癌, 35巻, 2号, pp. 79-79, Japanese口腔悪性腫瘍に対する粒子線治療成績[Refereed]International conference proceedings
- Apr. 2009, Japanese Journal of Radiology, 27巻, Suppl., pp. 58-58, Japanese転移性腫瘍に対する少分割粒子線治療の試み[Refereed]International conference proceedings
- THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, Apr. 2009, Japanese Journal of Radiology, 27巻, Suppl., pp. 58-58(4) (4), 831 - 832, Japanese[Refereed]International conference proceedings
- Apr. 2009, Japanese Journal of Radiology, 27巻, Suppl., pp. 12-12, Japanese原発性非小細胞肺癌に対する炭素線4回照射の初期報告[Refereed]International conference proceedings
- Apr. 2009, Japanese Journal of Radiology, 27巻, Suppl., pp. 48-48, JapaneseHCCに対する粒子線治療施行後Bilomaを形成した1例[Refereed]International conference proceedings
- Feb. 2009, 日本医学放射線学会学術集会抄録集, 巻, 68回, pp. S335-S335, Japanese粒子線治療後の皮膚炎に対する湿潤療法の初期経験[Refereed]International conference proceedings
- Feb. 2009, 日本医学放射線学会学術集会抄録集, 巻, 68回, pp. S220-S220, Japanese転移性肝腫瘍に対する粒子線治療[Refereed]International conference proceedings
- Feb. 2009, 日本医学放射線学会学術集会抄録集, 巻, 68回, pp. S334-S334, Japanese加速部分乳房照射における陽子線治療計画とX線治療計画の比較検討[Refereed]International conference proceedings
- 2009, IFMBE Proceedings, 25(1) (1), 878 - 882[Refereed]International conference proceedings
- 2009, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75(3) (3), S345 - S346, EnglishNovel Physiological Reaction after Proton Beam Therapy in Patients with Prostate Cancer: Urinary Activation[Refereed]Scientific journal
- (公社)日本医学放射線学会, Apr. 2008, Radiation Medicine, 26(Suppl.I) (Suppl.I), 47 - 47, Japanese乳癌放射線治療後に慢性好酸球性肺炎(CEP)を発症した1例
- PURPOSE: To investigate the incidence and influencing factors of acute genitourinary (GU) and gastrointestinal morbidities in patients with prostate cancer treated with proton therapy. METHODS AND MATERIALS: A total of 287 patients with histologically proven Stage cT1-T4N0M0 prostate cancer were treated with proton therapy between 2003 and 2004. Of these, 204 (71%) received neoadjuvant androgen suppression therapy. The patients were treated with 190-230-MeV protons using lateral-opposed techniques to a dose of 74 GyE. Dose-volume histogram analyses were performed. The incidence of acute morbidity was evaluated using the National Cancer Institute Common Toxicity Criteria, version 2.0. Clinical factors, including age, clinical target volume, initial prostate-specific antigen level, T stage, presence of diabetes mellitus, and the use of androgen suppression therapy, were investigated to determine whether those affected the incidence of acute GU morbidity. RESULTS: None developed Grade 2 or higher acute gastrointestinal morbidity. In contrast, 111 (39%) and 4 (1%) patients experienced acute Grade 2 and Grade 3 GU morbidities, respectively. However, 87% of the patients were successfully relieved by the administration of a selective alpha-1 blocker. Multivariate analysis showed that a larger clinical target volume (p = 0.001) and the use of androgen suppression therapy (p = 0.017) were significant factors for the prediction of acute Grade 2-3 GU morbidity. CONCLUSION: In our experience with proton therapy, a low incidence of acute gastrointestinal morbidity was observed. In contrast, the incidence of acute GU morbidity was similar to that in other reports of photon radiotherapy. Additional follow-up is warranted to elucidate the long-term safety and efficacy of proton therapy for prostate cancer.Oct. 2007, International journal of radiation oncology, biology, physics, 69(2) (2), 434 - 43, English, International magazine[Refereed]Scientific journal
- 2007, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69(3) (3), S57 - S57, EnglishSubacute central nervous system morbidity after proton therapy and carbon ion therapy against head and neck cancers and skull base tumors: Impact of sequential evaluation by MR imagings[Refereed]International conference proceedings
- [Bilateral massive ovarian edema: a case report including MR findings and etiology].A 42-year-old woman with bilateral massive ovarian edema (MOE) is presented. MOE is usually seen in women 6 to 33 years of age. Therefore, accurate re-operative assessment of MOE is important to avoid unnecessary oophorectomy procedures. MR findings of MOE are characteristic and reflect very well the diffuse stromal edema noted on microscopy. The etiology and MR findings of MOE are discussed.Oct. 2005, Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 65(4) (4), 455 - 8, Japanese, Domestic magazineScientific journal
- (公社)日本放射線腫瘍学会, Oct. 2005, 日本放射線腫瘍学会誌, 17(Suppl.1) (Suppl.1), 161 - 161, Japanese放射線抵抗性腫瘍の樹立とその分子メカニズムの検討
- (公社)日本放射線腫瘍学会, Oct. 2005, 日本放射線腫瘍学会誌, 17(Suppl.1) (Suppl.1), 118 - 118, Japanese頭頸部食道二重癌に対する全頸部・T字同時照射の経験
- (公社)日本放射線腫瘍学会, Oct. 2005, 日本放射線腫瘍学会誌, 17(Suppl.1) (Suppl.1), 154 - 154, Japanese眼付属器マルトリンパ腫におけるBCL10蛋白発現と予後・病期との関連性
- 2021, 頭頸部癌, 47(2) (2)T3N0M0声門癌に対する根治的放射線治療の成績
- 2021, 頭頸部癌, 47(2) (2)再発・転移頭頸部扁平上皮癌に対するニボルマブ療法治療の予後予測における好酸球数変化の有用性
- (NPO)日本緩和医療学会, Aug. 2020, Palliative Care Research, 15(Suppl.) (Suppl.), S37 - S37, Japanese骨転移の痛みのマネージメント 脊椎転移に対する経皮的椎体形成術の適応について考える
- (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 114 - 114, Japanese頭頸部癌における臓器温存療法は本当に機能温存につながっているのか 3D-CRTからIMRTへと変遷する中での放射線療法の課題
- (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 168 - 168, Japanese小児・若年の上咽頭癌3例の治療経験
- (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 174 - 174, Japanese頭頸部癌における免疫チェックポイント阻害薬後の救済化学療法についての後方視的検討
- (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 185 - 185, Japanese当院における頭頸部がんに対する高用量シスプラチン併用化学放射線療法による急性腎障害の後方視的検討
- (公社)日本医学放射線学会, Feb. 2020, Japanese Journal of Radiology, 38(Suppl.) (Suppl.), 40 - 40, Japanese木村氏病3例に対する放射線治療の経験
- (一社)日本小児血液・がん学会, Sep. 2019, 日本小児血液・がん学会雑誌, 56(2) (2), 148 - 152, Japanese
- (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 244 - 244, Japanese頭頸部癌に対する放射線治療後の放射線性顎骨壊死に関する検討
- (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 132 - 132, Japanese再発転移頭頸部扁平上皮癌 ニボルマブ投与例におけるmodified Glasgow Prognostic Scoreの予後予測性
- (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 162 - 162, Japanese再発転移鼻副鼻腔原発粘膜悪性黒色腫に対するニボルマブの後方視的検討
- (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 168 - 168, Japanese頭頸部扁平上皮癌術後の再発高リスク症例に対する放射線療法の治療成績の検討
- (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 169 - 169, Japanese中咽頭癌に対する化学放射線療法による摂食・嚥下に関するQOLの変化
- (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 174 - 174, Japanese頭頸部発生したグロームス腫瘍に対する放射線治療成績
- (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 201 - 201, JapaneseT4下咽頭癌に対する根治的(化学)放射線療法の後方視的検討
- (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 132 - 132, Japanese再発転移頭頸部扁平上皮癌 ニボルマブ投与例におけるmodified Glasgow Prognostic Scoreの予後予測性
- (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 162 - 162, Japanese再発転移鼻副鼻腔原発粘膜悪性黒色腫に対するニボルマブの後方視的検討
- (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 168 - 168, Japanese頭頸部扁平上皮癌術後の再発高リスク症例に対する放射線療法の治療成績の検討
- (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 169 - 169, Japanese中咽頭癌に対する化学放射線療法による摂食・嚥下に関するQOLの変化
- (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 174 - 174, Japanese頭頸部発生したグロームス腫瘍に対する放射線治療成績
- (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 201 - 201, JapaneseT4下咽頭癌に対する根治的(化学)放射線療法の後方視的検討
- (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 244 - 244, Japanese頭頸部癌に対する放射線治療後の放射線性顎骨壊死に関する検討
- (公社)日本医学放射線学会, Feb. 2019, Japanese Journal of Radiology, 37(Suppl.) (Suppl.), 34 - 34, Japanese肺癌術後局所領域再発に対する根治的放射線治療の治療成績の検討
- (公社)日本医学放射線学会, Feb. 2019, Japanese Journal of Radiology, 37(Suppl.) (Suppl.), 43 - 43, Japanese巨大腫瘤を呈した進行外陰癌3例に対する放射線治療の経験
- (公社)日本医学放射線学会, Feb. 2019, Japanese Journal of Radiology, 37(Suppl.) (Suppl.), 43 - 43, Japanese神経線維腫症1型(NF1)に生じた悪性末梢神経鞘腫に対する放射線治療経験
- 2019, 日本小児血液・がん学会雑誌(Web), 56(2) (2)小児がんに対する吸収性スペーサー留置を併用した粒子線治療
- (一社)日本がん看護学会, Jan. 2019, 日本がん看護学会誌, 33(Suppl.) (Suppl.), 271 - 271, Japanese多職種協働で行うがんサバイバーへの癒しをテーマに開催したイベントの実践報告と今後の課題
- (株)医学出版, Jul. 2018, WOC Nursing, 6(7) (7), 88 - 95, Japanese【創傷治癒の最前線】 放射線皮膚炎のアセスメントとケア[Invited]Introduction commerce magazine
- (株)全日本病院出版会, Sep. 2017, 整形外科最小侵襲手術ジャーナル, (84) (84), 79 - 83, Japanese[Refereed]Introduction scientific journal
- (株)メヂカルフレンド社, Aug. 2017, 看護技術, 63(9) (9), 860 - 864, Japanese[Invited]Introduction commerce magazine
- (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 144 - 144, Japanese個別化治療を目指した頭頸部癌診療ガイドライン 頭頸部がんに対する放射線治療の個別化 治療効果予測からの検討
- (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 177 - 177, Japanese局所進行頭頸部扁平上皮癌における導入化学療法TPFの安全性と有効性の検討
- (公社)日本医学放射線学会, Feb. 2017, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 46 - 46, Japanese当院におけるT3N0M0喉頭癌の放射線治療成績
- (株)日本臨床社, May 2016, 日本臨床, 74(増刊3 新前立腺癌学) (増刊3 新前立腺癌学), 503 - 507, Japanese[Invited]Introduction scientific journal
- (株)南江堂, Mar. 2016, がん看護, 21(3) (3), 392 - 395, Japanese[Invited]Introduction scientific journal
- (公社)日本医学放射線学会, Feb. 2016, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 49 - 49, Japanese当院におけるゼヴァリンの初期経験[Refereed]Meeting report
- 2016, 日本放射線腫瘍学会高精度放射線外部照射部会学術大会プログラム・抄録集, 29thTomotherapy HDによる全脳全脊髄照射の有用性と課題
- Nov. 2015, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93(3) (3), E341 - E342, EnglishRadiation Therapy for T3/T4 Squamous Cell Carcinoma of Hypopharynx: A Retrospective Comparison Between Definitive Radiation Therapy and Surgery Followed by Postoperative Radiation TherapySummary international conference
- Nov. 2015, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93(3) (3), E71 - E71, EnglishHypofractionated Stereotactic Radiation Therapy Compared With Stereotactic Radiosurgery for Brain Metastases From Lung Cancer: Experience at a Single-InstitutionSummary international conference
- Nov. 2015, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93(3) (3), E481 - E481, EnglishSpinal Instability Is Associated With Local Failure After Radiation Therapy in Patients With Spinal MetastasesSummary international conference
- Sep. 2014, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 90, S804 - S804, EnglishDose Estimation of Normal Brain Tissue Tolerance for Microbeam Radiation TherapySummary international conference
- Sep. 2014, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 90, S544 - S544, EnglishResult of Multimodal Treatment Including Radiation Therapy for Squamous Cell Carcinomas of Maxillary Sinus: A Retrospective StudySummary international conference
- (株)南江堂, Mar. 2014, がん看護, 19(3) (3), 319 - 323, JapaneseIntroduction scientific journal
- (一財)日本消化器病学会, Dec. 2013, 日本消化器病学会雑誌, 110(12) (12), 2073 - 2080, Japanese[Refereed][Invited]Introduction scientific journal
- Dec. 2013, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 110(12) (12), 2073 - 80, Japanese, Domestic magazine[Current status and future of the radiotherapy for pancreas cancer].
- Oct. 2013, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 87(2) (2), S472 - S473, EnglishRadiation-Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: Comparison Between Concurrent Chemoradiation Therapy and Radiation Therapy AloneSummary international conference
- Oct. 2013, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 87(2) (2), S366 - S366, EnglishEfficacy of Salvage Radiation Therapy in Men With Biochemical Recurrence After Radical Prostatectomy: A Comparison With Endocrine TherapySummary international conference
- Jul. 2013, がん看護, 18(5) (5), 110 - 115, Japanese放射線療法チームのスキルミクスと看護の役割Others
- (公社)日本婦人科腫瘍学会, Jun. 2013, 日本婦人科腫瘍学会雑誌, 31(3) (3), 412 - 412, Japanese子宮頸癌放射線治療の新展開 高齢子宮頸癌患者に対する根治的放射線治療の経験Meeting report
- (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2) (2), 264 - 264, Japanese鼻腔原発NK/T細胞リンパ腫に対する放射線治療経験Meeting report
- (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2) (2), 262 - 262, Japanese頭頸部扁平上皮癌に対する放射線治療後の甲状腺機能低下症に関する検討Meeting report
- (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2) (2), 186 - 186, Japanese当院におけるT3喉頭癌の放射線治療の経験Meeting report
- (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2) (2), 250 - 250, Japanese進行舌癌に対する術後放射線治療の経験Meeting report
- (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2) (2), 233 - 233, Japanese耳下腺癌/顎下腺癌術後症例に対する放射線治療の検討Meeting report
- (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2) (2), 237 - 237, Japanese甲状腺原発MALTリンパ腫の治療経験Meeting report
- (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2) (2), 264 - 264, JapaneseT1/2声門上癌に対する放射線治療成績の検討Meeting report
- (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2) (2), 184 - 184, Japanese5年以上経過観察した上咽頭癌症例に関する放射線療法の晩期有害反応の検討Meeting report
- (公社)日本医学放射線学会, Feb. 2013, 日本医学放射線学会学術集会抄録集, 72回(72回) (72回), S269 - S269, English低悪性度神経膠腫に対する放射線治療の経験(Clinical outcomes of radiotherapy for low-grade glioma)Meeting report
- (公社)日本医学放射線学会, Feb. 2013, 日本医学放射線学会学術集会抄録集, 72回(72回) (72回), S386 - S386, Japanese食道小細胞癌に対する放射線治療の経験Meeting report
- Nov. 2012, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 84(3) (3), S49 - S49, EnglishStereotactic Body Radiation Therapy in 95 Patients With Lung Tumors Composed of Ground-glass Opacity (GGO): Results of a Retrospective Multicenter StudySummary international conference
- Nov. 2012, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 84(3) (3), S491 - S491, EnglishPatterns of Local Recurrence and Metachronous Malignancy Following Radiation Therapy for Stage I or II Hypopharyngeal Carcinoma: Role of Close Observation and Multidisciplinary ApproachSummary international conference
- PURPOSE: To evaluate the long-term treatment outcome and disease behavior of primary ocular adnexal MALT (mucosa-associated lymphoid tissue) lymphoma (POAML) after treatment with radiotherapy. METHODS AND MATERIALS: Seventy-eight patients (42 male, 36 female) diagnosed with stage I POAML between 1991 and 2010 at Kobe University Hospital were included. The median age was 60 years (range, 22-85 years). The median radiation dose administered was 30.6 Gy. Rituximab-based targeted therapy and/or chemotherapy was performed in 20 patients (25.6%). Local control (LC), recurrence-free survival (RFS), and overall survival (OS) rates were calculated using the Kaplan-Meier method. RESULTS: The median follow-up duration was 66 months. Major tumor sites were conjunctiva in 37 patients (47.4%), orbita in 29 (37.2%), and lacrimal glands in 12 (15.4%). The 5- and 10-year OS rates were 98.1% and 95.3%, respectively. The 5- and 10-year LC rates were both 100%, and the 5- and 10-year RFS rates were 88.5% and 75.9%, respectively. Patients treated with a combination of radiotherapy and targeted therapy and/or chemotherapy had a trend for a better RFS compared with those treated with radiotherapy alone (p = 0.114). None developed greater than Grade 2 acute morbidity. There were 14 patients who experienced Grade 2 morbidities (cataract: 14; retinal disorders: 7; dry eye: 3), 23 patients who had Grade 3 morbidities (cataract: 23; dry eye: 1), and 1 patient who had Grade 4 glaucoma. CONCLUSIONS: Radiotherapy for POAML was shown to be highly effective and safe for LC and OS on the basis of long-term observation. The absence of systemic relapse in patients with combined-modality treatment suggests that lower doses of radiation combined with targeted therapy may be worth further study.15 Mar. 2012, International journal of radiation oncology, biology, physics, 82(4) (4), 1509 - 14, English, International magazine
- Sep. 2011, EUROPEAN JOURNAL OF CANCER, 47, S563 - S563, EnglishCombined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus - a Retrospective StudySummary international conference
- (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 257 - 257, Japanese上顎洞扁平上皮癌に対する放射線治療成績
- 2011, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81(2) (2), S523 - S524, EnglishCombined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus: A Retrospective StudySummary international conference
- 2011, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81(2) (2), S285 - S285, EnglishRadiation Therapy for Brain Stem Gliomas in Children and AdultsSummary international conference
- 2011, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81(2) (2), S281 - S282, EnglishDosimetric Analysis of Patterns of Failure for High-grade Glioma with Multimodality Treatment: Relationship to MIB-1 Labeling IndexSummary international conference
- 2011, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81(2) (2), S574 - S574, EnglishProton Beam Therapy and Carbon-ion Radiotherapy for T2a-T2bN0M0 Non-small Cell Lung CancerSummary international conference
- 2010, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78(3) (3), S407 - S408, EnglishRadiotherapy for Elderly Patients with Cervical CancerSummary international conference
- 2010, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78(3) (3), S613 - S613, EnglishParticle-Beam Radiation Therapy for Skull Base Chordomas: A Retrospective StudySummary international conference
- 2010, Kobe J. Med. Sci., 2(56) (56), E38-E49Vitamin K2 derived compounds induce growth inhibition in radioresistant cancer cells
- Sep. 2009, EJC SUPPLEMENTS, 7(2) (2), 477 - 477, EnglishParticle therapy for mucosal malignant melanoma of the head and neck: a retrospective studySummary international conference
- 日本肺癌学会, 05 Oct. 2008, 肺癌, 48(5) (5), 428 - 428, JapaneseWS9-1 I期非小細胞肺癌に対する粒子線治療成績(放射線治療の現状と展望,第49回日本肺癌学会総会号)
- 日本肺癌学会, 05 Oct. 2008, 肺癌, 48(5) (5), 463 - 463, JapaneseO-75 3期肺癌に対する粒子線・治療の経験(放射線・集学的治療,第49回日本肺癌学会総会号)
- (公社)日本医学放射線学会, Apr. 2008, Radiation Medicine, 26(Suppl.I) (Suppl.I), 52 - 52, Japanese巨大肝癌に対して2回の陽子線治療で制御できた1例
- 2008, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 72(1) (1), S404 - S405, EnglishParticle therapy for adenoid cystic carcinoma of the head and neck: A retrospective studySummary international conference
- Sep. 2007, EJC SUPPLEMENTS, 5(4) (4), 296 - 297, EnglishConfirmation of proton beam by positron emission tomography apparatus in patients with prostate cancerSummary international conference
- Sep. 2007, EJC SUPPLEMENTS, 5(4) (4), 294 - 294, EnglishProton radiotherapy for patients with prostate cancer - in the Hyogo Ion Beam Medical Center (HIBMC) experienceSummary international conference
- Purpose: To identify the impact of atopic manifestations on the occurrence of the lung toxicity following chest irradiation for breast cancer.Japanese Society for Therapeutic Radiology and Oncology, Jun. 2007, 日本放射線腫瘍学会誌, 19(2号) (2号), 109 - 116, Japanese
Patients and Methods: Collection of 1,173 patients who had undergone radiotherapy on their 1,177 chest walls or postsurgical mammary glands at 9 institutions including ours. They received treatment consecutively from December 1980 through October 2005, with which we formed the basis of this analysis. Patients with any of the following medical history were defined as having atopic manifestations (n=111): asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, and allergy to food or drug. Of them, patients who were observed for at least 6 months or who suffered from lung toxicity at any time, were classified as Group A (n=85). On the other hand, patients in our institute who were observed for at least 6 months or who suffered from lung toxicity at any time regardless of atopic manifestations, were classified as Group B (n=113), and patients without any atopic manifestation were classified as Group C (n=92).
Results: Grade 3 or higher lung toxicity in NCI-CTCAE (v 3.0), occurred in 8.2%, i.e. 7 cases, of Group A, 2.7% of Group B, and 1.1% of Group C (p=0.0293 Group C against Group A). Three cases were classified as classical pneumonitis, and the other 4 sporadic pneumonitis such as Cryptogenic Organizing Pneumonia and Chronic Eosinophilic Pneumonia. Both of the histologically proven COP and CEP patients showed atopic manifestations in our institute. The detail clinical features are described in the main text.
Conclusion: Having atopic manifestations suggests that there may be risk of lung toxicity following chest irradiation for breast cancer.[Refereed]Introduction scientific journal - (公社)日本医学放射線学会, Apr. 2007, Radiation Medicine, 25(Suppl.I) (Suppl.I), 71 - 71, Japanese胃に再発をきたした結膜原発MALTリンパ腫の1例
- 2007, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69(3) (3), S356 - S356, EnglishConfirmation of proton beam by positron emission tomography (PET) apparatus in patients with prostate cancerSummary international conference
- 2007, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69(3) (3), S266 - S266, EnglishProton therapy and carbon ion therapy for patients with hepatocellular carcinoma: The hyogo ion beam medical center experienceSummary international conference
- 日本肺癌学会, 20 Aug. 2006, 肺癌, 46(4) (4), 385 - 385, Japanese14. 炭素イオン線治療が奏効した肺肉腫の1例(第84回 日本肺癌学会関西支部会,関西支部,支部活動)
- Oct. 2005, EJC SUPPLEMENTS, 3(2) (2), 284 - 284, EnglishAberrant cytoplasmic BCL10 expression reflects advanced disease in patients with mucosa-associated lymphoid tissue lymphoma of ocular adnexaSummary international conference
- (公社)日本放射線腫瘍学会, Oct. 2005, 日本放射線腫瘍学会誌, 17(Suppl.1) (Suppl.1), 145 - 145, Japanese前立腺癌に対する陽子線治療前の直腸内視鏡検査の意義
- (公社)日本医学放射線学会, Oct. 2005, 日本医学放射線学会雑誌, 65(4) (4), 455 - 458, Japanese
- Others, 学研メディカル秀潤社, Jul. 2017, Japaneseがん・放射線療法2017 / 第7章 下垂体腫瘍Scholarly book
- Others, INTECH, 2017, EnglishRadiotherapy / New paradigm of radiotherapy for bone metastasis.Scholarly book
- Others, INTECH, 2017, EnglishRadiotherapy / Image-Guided Adaptive,Brachytherapy for Cervical Cancer Using Magnetic Resonance Imaging: Overview and Experience.Scholarly book
- Others, 日本看護協会出版会, Jun. 2016, Japanese多職種チームで実践する頭頸部癌の化学放射線療法 / 口腔内粘膜反応Scholarly book
- Others, 株式会社じほう, 2016, Japanese外来患者をサポートする がん薬物療法マネジメントブック / 第2章 がん薬物療法のマネジメントに役立つ情報と活用術、3.検査所見 1)モダリティの特徴・用途Textbook
- Others, メディカル教育研究社, Sep. 2013, Japanese決定版 チームで取り組む 乳がん放射線療法 / 乳がん放射線療法の有害事象 頭部Textbook
- Joint work, 日本看護協会出版会, Feb. 2011, Japaneseカラーアトラス 目で見て学ぶ 放射線療法の有害反応 多職種チームで実践する治療と患者支援 / 放射線療法の理解 / 【放射線療法と併用療法の理解】放射線療法の理解Textbook
- Joint work, 日本看護協会出版会, Feb. 2011, Japaneseカラーアトラス 目で見て学ぶ 放射線療法の有害反応 多職種チームで実践する治療と患者支援 / 放射線療法の理解Textbook
- Joint work, 日本看護協会出版会, Feb. 2011, Japaneseカラーアトラス 目で見て学ぶ 放射線療法の有害反応 多職種チームで実践する治療と患者支援 / 放射線皮膚炎Textbook
- Others, INTECH, 2011, EnglishCervical Cancer / Cervical cancer treatment in aging womenTextbook
- Joint work, 篠原出版新社, Nov. 2010, Japaneseがん・放射線療法2010 / 7-8 下垂体腫瘍Textbook
- 第321回公益社団日本医学放射線学会関西地方会(第391回レントゲンアーベント), Feb. 2019, Japanese, 公益社団日本医学放射線学会関西地方会, 大阪, Domestic conference稀な松果体乳頭状腫瘍に対して放射線治療を施行した症例Oral presentation
- 日本放射線腫瘍学会第31回学術大会, Oct. 2018, Japanese, 日本放射線腫瘍学会, 京都, Domestic conference頭頸部扁平上皮癌術後の再発高リスク症例に対する放射線療法の治療成績の検討Oral presentation
- 日本放射線腫瘍学会第31回学術大会, Oct. 2018, Japanese, 日本放射線腫瘍学会, 京都, Domestic conference当院における悪性脳神経膠腫に対するIMRTの治療成績Oral presentation
- 日本放射線腫瘍学会第31回学術大会, Oct. 2018, Japanese, 日本放射線腫瘍学会, 京都, Domestic conference巨大腫瘤を呈した進行外陰癌3例に対する放射線治療の経験Oral presentation
- 日本放射線腫瘍学会第31回学術大会, Oct. 2018, Japanese, 日本放射線腫瘍学会, 京都, Domestic conference還元型コエンザイムQ10の摂取形状による放射線防護効果の変化Poster presentation
- ASTRO's 60th Annual Meeting, Oct. 2018, English, ASTRO, San Antonio, International conferenceTreatment outcomes of radiotherapy or chemoradiotherapy for postoperative locoregional recurrence of non-small cell lung cancer.Poster presentation
- 日本放射線腫瘍学会第31回学術大会, Oct. 2018, Japanese, 日本放射線腫瘍学会, 京都, Domestic conferenceA newly developed bio-degradable fiducial marker for image-guided radiotherapyPoster presentation
- 第43回神戸放射線腫瘍懇話会, Sep. 2018, Japanese, 神戸放射線腫瘍懇話会, 神戸, Domestic conference頭頸部癌に対する根治放射線治療後の放射線性顎骨壊死に関する臨床的検討Oral presentation
- 第319回公益社団日本医学放射線学会関西地方会(第391回レントゲンアーベント), Jun. 2018, Japanese, 公益社団日本医学放射線学会関西地方会, 大阪, Domestic conference木村氏病3例に対する放射線治療の経験Oral presentation
- 第42回日本頭頸部癌学会, Jun. 2018, Japanese, 日本頭頸部癌学会, 東京, Domestic conference甲状腺癌気管浸潤例に対する放射線外照射の有効性の検討Oral presentation
- World Congress on Medical Physics and Biomedical Engineering 2018, Jun. 2018, English, Prague, International conferenceApplication of dual-energy CT to suppression of metal artifacts caused by spinal implant in radiotherapyOral presentation
- 第77回日本医学放射線学会総会, Apr. 2018, Japanese, 日本医学放射線学会, 横浜, Domestic conference局所進行直腸癌に対する術前化学放射線療法の治療成績Oral presentation
- 日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference非小細胞肺癌術後再発に対する放射線治療の検討Poster presentation
- 日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference当院における低・中リスク前立腺癌に対するヨード永久刺入療法の治療成績Poster presentation
- 日本放射線腫瘍学会小線源部会第19回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 奈良, Domestic conference当院における低・中リスク前立腺癌に対するヨード永久刺入療法の治療成績Oral presentation
- 日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference当院における胃非ホジキンリンパ腫に対する放射線治療の経験Poster presentation
- 第317回公益社団法人日本医学放射線学会関西地方会(第389回レントゲンアーベント), Nov. 2017, Japanese, 日本医学放射線学会, 大阪, Domestic conference神経線維腫症1型(NF1)に生じた悪性末梢神経鞘腫に対する放射線治療経験Oral presentation
- 日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference小線源治療開始時の残存腫瘍体積と腫瘍縮小率に基づく子宮頸癌患者のリスク分類Oral presentation
- 日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference子宮頸部腺癌に対する根治的放射線治療成績の検討Poster presentation
- 日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conferenceExperience of Neoadjuvant Chemoradiotherapy for locally advanced rectal cancerOral presentation
- 第317回公益社団法人日本医学放射線学会関西地方会(第389回レントゲンアーベント), Nov. 2017, Japanese, 日本医学放射線学会, 大阪, Domestic conference巨大腫瘤を呈した進行外陰癌3例に対する放射線治療の経験Oral presentation
- 日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conferenceStudy on PET-CT in judgment of therapeutic effect of radiotherapy for lymph node metastasisPoster presentation
- ASTRO's 59th Annual Meeting, Nov. 2017, English, American Society for Radiation Oncology, San Diego, International conferenceRisk Group Analyses in Cervical Cancer Patients Based on Residual Tumor Volume and Tumor Reduction Ratio at the Time of Image Guided Adaptive BrachytherapyPoster presentation
- 日本放射線腫瘍学会第30回学術大会, Nov. 2017, English, 日本放射線腫瘍学会, 大阪, Domestic conferenceNovel application of Dual Energy CT for the suppression of metal artifact in RadiotherapyPoster presentation
- 日本放射線腫瘍学会第30回学術大会, Oct. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference子宮頸癌に対する組織内照射併用腔内照射と腔内照射治療計画の比較Oral presentation
- 日本放射線腫瘍学会第30回学術大会, Oct. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conferenceメタボロミクスにおける放射線消化管機能不全指標の解明Oral presentation
- 日本放射線腫瘍学会第30回学術大会, Sep. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference脳転移に対して定位照射を施行ごとに繰り返し神経症状を呈した1例Poster presentation
- 日本放射線腫瘍学会第30回学術大会, Sep. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference還元型コエンザイムQ10による腸管の有害事象軽減の検討Poster presentation
- 日本放射線腫瘍学会第30回学術大会, Sep. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference胃癌の多発肝転移、下大静脈腫瘍栓に対して全肝照射を施行した一例Poster presentation
- 日本放射線腫瘍学会第29回学術大会, Sep. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conferenceマーカー認識型動体追跡システムにおけるマーカー認識評価Poster presentation
- 日本放射線腫瘍学会第30回学術大会, Jul. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference多施設共同による頭頸部ハンドブックの作成 -放射線治療後の有害事象へのサポート-Poster presentation
- 日本放射線腫瘍学会第30回学術大会, Jul. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference上咽頭癌に対する強度変調放射線治療を用いた放射線療法の初期経験Poster presentation
- 第41回日本頭頸部癌学会, Jun. 2017, Japanese, 日本頭頸部癌学会, 京都, Domestic conferenceInduction chemotherapy of TPF for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) - A retrospective safety analysis at our institution -Oral presentation
- The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conferenceTreatment outcome of definitive radiotherapy for primary malignant tumor of nasal cavityPoster presentation
- 第314回公益社団法人日本医学放射線学会関西地方会(第386回レントゲンアーベント), Nov. 2016, Japanese, 日本放射線学会, 大阪(ホテルエルセラーン大阪), Domestic conference当院における子宮頸部腺癌の根治的放射線治療の治療成績の検討Oral presentation
- The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conferenceChange in the ADC value during the period of whole pelvic radiotherapy for cervical cancerPoster presentation
- The 29h Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conferenceStereotactic body radiotherapy for second primary lung cancer and intra-parenchymal lung metastasis in patients previously treated with surgeryOral presentation
- The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conferencePhysical analysis of the animal irradiation system in the Kobe UniversityPoster presentation
- The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conferenceOutcomes of Sequential Chemoradiotherapy for Small-Cell Lung Cancer in Patients Unsuitable for CCRTPoster presentation
- The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conferenceOutcomes after radiation therapy for recurrent carcinoma of the oral tongueOral presentation
- The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conferenceNext-stage Bioabsorbable Spacer in Particle TherapyPoster presentation
- The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conferenceElucidation of the radiation gastrointestinal dysfunction index using metabolomicsOral presentation
- The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conferenceEffectiveness of micro-slit beam radiation therapy for multiplelung-metastatic tumorOral presentation
- The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conferenceComparison of dosimetric parameters in the MRI based IGABT with and without optimizationPoster presentation
- The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conferenceChanges of ADC and T2 values during external beam radiotherapy for cervical cancerOral presentation
- The 1st Meeting of the Federation of Asisan Organizations for Radiation Oncology (FARO) held in conjunction with the 29th Annual Meeting of the Japanese Society for Radiation Oncology (JASTRO), Nov. 2016, English, Japanese Society for Radiation Oncology, 京都, International conferenceAssessment of the threshold dose for radiation fibrosis in thoracic esophageal cancer patientsPoster presentation
- The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conferenceAssessment of dose calculation accuracy with lung heterogeneity phantomPoster presentation
- The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conferenceA case of uterine cervical cancer presenting with dermatomyositis as a paraneoplastic syndromePoster presentation
- The 40th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2016, Japanese, Japan Society for Head and Neck Cancer, Saitama, Japan, 埼玉、ソニックシティー, Domestic conference鼻腔腫瘍に対する放射線治療の経験Oral presentation
- The 40th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2016, Japanese, 日本頭頸部癌学会, 大宮, Domestic conferenceOutcomes after radiation therapy for recurrent carcinoma of the oral tongueOral presentation
- The 75th Annual Meeting of the Japan Radiological Society, Apr. 2016, English, Japan Radiological Society, 横浜, Domestic conferenceradiotherapy for cervical lymph node metastases of unknown primary siteOral presentation
- The 75th Annual Meeting of the Japan Radiological Society, Apr. 2016, Japanese, Japan Radiological Society, 横浜, Domestic conferenceOne-year Experience of MRI Based Image Guided Adaptive Brachytherapy for Cervical CancerPoster presentation
- The 75th Annual Meeting of the Japan Radiological Society, Apr. 2016, Japanese, Japan Radiological Society, 横浜, Domestic conferenceDefinitive Radiotherapy for T3/T4 Hypopharyngeal Squamous Cell CarcinomaOral presentation
- The 4th International Symposium of Training Plan for Oncology Professionals, Feb. 2016, English, 大阪, International conferenceDiscovery of novel Index of radiation gastrointestinal disorders via metabolomicsOral presentation
- The 4th International Symposium of Training Plan for Oncology Professionals, Feb. 2016, English, 大阪, International conferenceAssessment of Apparent Diffusion Coefficient during Image Guided Adaptive Brachytherapy for the Prediction of Local Controllability in Cervical Cancer Treatment: A preliminary histogram analysisPoster presentation
- The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conferenceResponse of multiple lung-metastatic tumor to microplanar beam irradiationOral presentation
- The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conferenceRadiotherapy for portal vein tumor thrombosis or inferior vena cava tumor thrombosis: Comparison with stereotactic body radiotherapy and 3-dimensional conformal radiotherapyOral presentation
- The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conferenceRADIOTHERAPY FOR CERVICAL LYMPH NODE METASTASES OF UNKNOWN PRIMARY SITEOral presentation
- The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conferenceRadiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: a Dose-Volume Histogram AnalysisOral presentation
- The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conferencePattern of recurrence after high-dose methotrexate followed by radiotherapy for primary central nervous system lymphomaPoster presentation
- The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conferenceOutcomes of radiotherapy for oro- or hypopharyngeal cancer with concomitant esophageal cancerPoster presentation
- The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conferenceImprovement of Abdominal Radiation-induced Anorexia by RikkunshitoPoster presentation
- The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conferenceEffects of the synchrotron X-ray microbeam spacing on mouse normal brain tissueOral presentation
- The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, English, JASTRO, 群馬, Domestic conferenceEarly Experience of Image Guided Adaptive Brachytherapy using Magnetic Resonance ImagingOral presentation
- The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conferenceA Future Radiosensitizor from the Spinach, MGDG, Induced Apoptosis in the Pancreatic Cancer Cells Combined with Radiation In vitro and In vivoOral presentation
- 57th Annual Meeting of the American Society for Radiation Oncology (ASTRO), Oct. 2015, English, American Society for Radiation Oncology, San Antonio, USA, International conferenceSpinal Instability Is Associated With Local Failure After Radiation Therapy in Patients With Spinal MetastasesPoster presentation
- 57th Annual Meeting of ASTRO, Oct. 2015, English, ASTRO, San Antonio, USA, International conferenceRadiotherapy for T3/T4 squamous cell carcinoma of hypopharynx: retrospective comparison between definitive radiotherapy and surgery followed by postoperative radiotherapyPoster presentation
- 57th Annual Meeting of ASTRO, Oct. 2015, English, ASTRO, San Antonio, USA, International conferenceRadiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: a Dose-Volume Histogram AnalysisPoster presentation
- 57th Annual Meeting of ASTRO, Oct. 2015, English, ASTRO, San Antonio, USA, International conferenceHypofractionated Stereotactic radiotherapy Compared with Stereotactic Radiosurgery for brain metastases from Lung Cancer: Experience at a Single InstitutionPoster presentation
- ASTRO 57th Annual Meeting, Oct. 2015, English, ASTRO, San Antonio, USA, International conferenceA Novel Radiosensitizor from the Component of Spinach, MGDG, Induced Apoptosis in the Pancreatic Cancer Cells Combined with RadiationPoster presentation
- 第311 回日本医学放射線学会関西地方会, Oct. 2015, Japanese, 日本医学放射線学会関西地方会, 大阪, Domestic conference80歳以上の子宮頸癌患者に対する放射線治療の経験Oral presentation
- 神戸放射線腫瘍懇話会, Sep. 2015, Japanese, 神戸, Domestic conference当院におけるMRIを用いた婦人科癌画像誘導小線源治療の運用と初期経験Oral presentation
- European Cancer Congress 2015, Sep. 2015, English, European Cancer Congress, Vienna, Austria, Austria, International conferenceRadiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: a Dose-Volume Histogram AnalysisPoster presentation
- 4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, English, Japan Society for Head and Neck Cancer, 神戸, International conferenceRADIOTHERAPY FOR CERVICAL LYMPH NODE METASTASES OF UNKNOWN PRIMARY SITEPoster presentation
- 第56回JROG 関西若手放射線治療勉強会, Jun. 2015, Japanese, JROG, 奈良, Domestic conferenceVolumetric modulated arc therapy (VMAT) for head and neck cancer: A planning study on our institutionOral presentation
- 4th Congress of Asian Society of Head and Neck Oncology 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, Japanese, Japan Society for Head and Neck Cancer, 神戸, Domestic conferenceTreatment outcomes of definitive radiotherapy in patients with T3N0M0 laryngeal cancerPoster presentation
- The 3rd Japan-Taiwan Radiation Oncology Symposium, Jun. 2015, English, The 3rd Japan-Taiwan Radiation Oncology Symposium, 山梨, International conferenceSALVAGE RADIOTHERAPY versus HORMONAL THERAPY for localized prostate cancer patients with biochemical failure AFTER RADICAL PROSTATECTOMYOral presentation
- 4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, English, 神戸国際会議場, 神戸, International conferenceRadiotherapy for posterior pharyngeal wall cancer of oropharynx and/or hypopharynxPoster presentation
- The 3rd Japan-Taiwan Radiation Oncology Symposium, Jun. 2015, English, The 3rd Japan-Taiwan Radiation Oncology Symposium, 山梨, International conferenceRadiotherapy for portal vein tumor thrombosis or inferior vena cava tumor thrombosisOral presentation
- 4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, Japanese, 神戸国際会議場, 神戸, International conferenceRadiotherapy for Head and Neck Cancers with N3 Lymph Node MetastasisPoster presentation
- 第39回日本頭頸部癌学会学術集会, Jun. 2015, English, 日本頭頸部癌学会, 神戸, Domestic conferencePrognostic value of the Inflammation Scores for Platinum Refractory Head and Neck cancer.Oral presentation
- 4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, English, Japan Society for Head and Neck Cancer, 神戸, International conferenceOutcomes of radiotherapy for oro and hypopharyngeal cancer with concomitant esophageal cancerPoster presentation
- 4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, English, Japan Society for Head and Neck Cancer, 神戸, International conferenceDefinitive radiotherapy for T3/T4 hypopharyngeal squamous cell carcinomaPoster presentation
- 4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, English, Japan Society for Head and Neck Cancer, 神戸, International conferenceA Novel method of Radioprotection for the Gastointestinal System: Efficacy of the reduced form of Coenzyme Q10.Poster presentation
- The 3rd Japan-Taiwan Radiation Oncology Symposium, Jun. 2015, English, The 3rd Japan-Taiwan Radiation Oncology Symposium, 山梨, International conferenceA Future Method: Space Modulated Particle Therapy (SMPT) Using a Novel Bioabsorbable SpacerOral presentation
- 15th International Congress of Radiation Research, May 2015, English, ICRR, 京都, International conferenceTolerance for Micro-slit beam X-ray radiation to Central Nervous SystemPoster presentation
- The 15th International Congress of Radiation Research, May 2015, English, 京都, International conferenceSpinal instability is associated with local recurrence after radiotherapy in patients with spinal metastasesPoster presentation
- 15th International Congress of Radiation Research, May 2015, English, International Congress of Radiation Research, 京都, International conferenceRadiotherapy for portal vein tumor thrombosis or inferior vena cava tumor thrombosis of hepatocellular carcinomaPoster presentation
- 15th International Congress of Radiation Research, May 2015, English, ICRR, 京都, International conferenceRadiosensitizor extracted from Spinach, MGDG, Enhanced the Cytotoxic Effect for Pancreatic Cancer Cells when combined with Radiation TreatmentPoster presentation
- 15th International Congress of Radiation Research, May 2015, English, 京都, International conferenceRadioimmunotherapy with 90Y ibritumomab tiuxetan for low grade malignant lymphoma.Poster presentation
- 15th International Congress of Radiation Research, May 2015, English, International Congress of Radiation Research, 京都, International conferenceRadiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and NeckPoster presentation
- MODERN RADIATION FOR LYMPHOMA, UPDATED ROLE AND NEW RULES, May 2015, English, International Lymphoma Radiation Oncology Group, NewYork, USA, International conferencePattern of recurrence after high-dose methotrexate followed by radiotherapy for primary central nervous system lymphomaPoster presentation
- 15th International Congress of Radiation Research, May 2015, English, 京都, International conferenceNext-stage Bioabsorbable Spacer in Particle TherapyPoster presentation
- The 74rd Annual Meeting of the Japan Radiological Society, Apr. 2015, English, The Japan Radiological Society, 横浜, Domestic conferenceTreatment results of three dimensional Conformal Radiotherapy and Stereotactic Body Radiotherapy for Portal Vein Tumor Thrombosis or Inferior Vena Cava Tumor Thrombosis in hepatocellular carcinomaPoster presentation
- 第74回日本医学放射線学会, Apr. 2015, English, 日本医学放射線学会, 横浜, Domestic conferencePrognostic factors for local control and survival after radiotherapy in patients with spinal metastasesOral presentation
- 第309 回日本医学放射線学会関西地方会, Feb. 2015, Japanese, 日本医学放射線学会関西地方会, 大阪, Domestic conference鼻腔腫瘍に対する放射線治療の経験Oral presentation
- The 27th Annual Meeting of the Japanese society for Radiation Oncology, Dec. 2014, Japanese, The Japanese society for Radiation Oncology, 横浜, Domestic conference脊椎転移による脊髄損傷リスクの検討(第2報)Oral presentation
- 日本放射線腫瘍学会第27回学術大会, Dec. 2014, Japanese, 日本放射線腫瘍学会, 横浜、パシフィコ横浜, Domestic conference進行食道癌による通過障害対する緩和的放射線治療の成績Oral presentation
- 日本放射線腫瘍学会第27回学術大会, Dec. 2014, Japanese, 日本放射線腫瘍学会, 横浜、パシフィコ横浜, 上顎洞扁平上皮癌に対する超選択的動注化学療法併用放射線療法の成績を遡及的に検討, Domestic conference上顎洞癌に対する超選択的動注化学療法併用放射線療法の治療成績Poster presentation
- 第54回日本核医学会学術総会, Nov. 2014, Japanese, The Japan Nuclear Medicine, 大阪, Domestic conference治療前FDG-PETによる喉頭癌の再発予測Oral presentation
- 第308 回日本医学放射線学会関西地方会, Oct. 2014, Japanese, 日本医学放射線学会関西地方会, 大阪, 乳癌経過中に癌性髄膜炎との鑑別に苦慮したクリプトコッカス髄膜炎についての一例報告, Domestic conference乳癌経過中に癌性髄膜炎との鑑別に苦慮したクリプトコッカス髄膜炎の一例Oral presentation
- 第308 回日本医学放射線学会関西地方会, Oct. 2014, Japanese, 日本医学放射線学会関西地方会, 大阪, 低リスク前立腺癌に対する永久刺入小線源治療についての報告, Domestic conference低リスク前立腺癌に対する永久刺入小線源治療の経験 ~成績と有害事象~Oral presentation
- MMND & IPCT 2014, Oct. 2014, English, University of Wollo0ngong, Port Douglas, Australia, International conferenceEfficacy of PGA Spacer in Particle Therapy: A novel strategy Making Temporal Space between Tumor and Adjacent Organs[Invited]Invited oral presentation
- KASTRO2014, Sep. 2014, Japanese, KASTRO, Kobe, Domestic conferenceTrueBeamシステムによる呼吸同期強度変調回転放射線治療の検討Oral presentation
- The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, We retrospectively reviewed 9 cases who underwent radiotherapy with Cetuximab concurrently. Primary tumor response and acute toxicity are reported. Although mucositis was the most remarkable adverse events, one patient developed grade 5 drug-induced interstitial lung disease., International conferenceRetrospective analysis of whole brain radiotherapy for brain metastasesPoster presentation
- The 15th Asian Oceanian Congress of Radiology, Sep. 2014, English, Asian Oceanian Congress of Radiology, 神戸, International conferenceRetrospective analysis of risk factors influencing survival and gait disturbance in patients with spinal metastasesPoster presentation
- The 15th Asian Oceanian Congress of Radiology, Sep. 2014, English, Asian Oceanian Congress of Radiology, Kobe, The purpose of this study was to compare the risk of HT in squamous cell carcinoma of the head and neck undergoing treatment with CCRT or RT alone at our institution, International conferenceRadiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and NeckPoster presentation
- The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, Domestic conferenceHypofractionated Stereotactic radiotherapy Compared with Stereotactic Radiosurgery for brain metastases from Lung Cancer: Experience at a Single InstitutionPoster presentation
- The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, International conferenceExperience of radiotherapy plus cetuximab for head and neck cancerPoster presentation
- ASTRO’s 56th Annual Meeting, Sep. 2014, English, American Society for Radiation Oncology, San Francisco, USA, International conferenceDose Estimation Of Normal Brain Tissue Tolerance For Microbeam Radiation TherapyPoster presentation
- The 15th Asian Oceanian Congress of Radiology, Sep. 2014, English, Kobe, International conferenceAssessment of Correlation and Prediction Errors of the CyberKnife Synchrony Respiratory Tracking Ststem for the Treatment of Liver TumorsPoster presentation
- The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, International conferenceA Novel Radiosensitizer, Monogalactosyl diacylglycerol, Enhanced the Cytotoxic Effects for the Pancreatic CancerPoster presentation
- The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, International conferenceA Novel Method for Space Modulated Radiotherapy (SMRT):Nonwoven fabric polyglycolic acid (PGA) spacerPoster presentation
- The 15th Asian Oceanian Congress of Radiology AOCR_2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, International conferenceA Novel Metallic Eye Shield for Electron Treatment in Eyelid Skin Cancer: A Dosimetric StudyPoster presentation
- IFHNOS 2014, Jul. 2014, English, International Federation of Head & Neck Oncologic Societies (IFHNOS), NY, USA, International conferenceCyberknife Radiotherapy For Recurrent Head And Neck CancersPoster presentation
- The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, Domestic conferenceExperience of radiotherapy plus cetuximab for head and neck cancerPoster presentation
- 第307回公益社団法人日本医学放射線学会関西地方会(第379回レントゲンアーベント), Jun. 2014, Japanese, 公益社団法人日本医学放射線学会関西地方会, 大阪, Domestic conference当院におけるゼヴァリンの初期経験Oral presentation
- The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, 中咽頭癌に対する化学放射線療法におけるPEG留置患者の栄養投与量と有害事象を検討, Domestic conference中咽頭癌に対する化学放射線療法におけるPEG留置患者の栄養投与量と有害事象Oral presentation
- The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, 上顎洞扁平上皮癌に対する放射線治療成績を検討, Domestic conference上顎洞扁平上皮癌に対する放射線治療成績Poster presentation
- The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, Domestic conferenceT3N0-1声門癌に対する喉頭温存を目的とした根治的化学放射線治療の検討Oral presentation
- The 73rd Annual Meeting of the Japan Radiological Society, Apr. 2014, English, The Japan Radiological Society, 横浜、パシフィコ横浜, [Objective] The purpose of this study is to evaluate the results of T3 laryngeal cancer with radiotherapy in our institution.[Materials and Methods] Between 2006 and 2013, 20 patients with T3 laryngeal cancer treated with radiotherapy in our institution. Sixteen patients was diagnosed with N0, 2 patients did with N1, 1 patient did with N2, and 1 patient did with N3 disease. Sev, Domestic conferenceDefinitive radiotherapy for T3 laryngeal cancerOral presentation
- The 73rd Annual Meeting of Japan Radiological Society, Apr. 2014, English, The Japan Radiological Society, 横浜、パシフィコ横浜, Domestic conferenceEfficacy of Salvage Radiotherapy in Men with Biochemical Recurrence After Radical Prostatectomy: A Comparison with Endocrine Therapy[Invited]Invited oral presentation
- The 73rd Annual Meeting of the Japan Radiological Sociey, Apr. 2014, Japanese, The Japan Radiological Sociey, 横浜, Domestic conferenceRetrospective analysis of risk factors influencing survival and gait disturbance in patients with spinal metastasesOral presentation
- The 73rd Annual Meeting of the Japan Radiological Society, Apr. 2014, Japanese, The Japan Radiological Society, 横浜、パシフィコ横浜, Domestic conferenceTreatment outcomes of radiotherapy for T1/T2 supraglottic carcinomaPoster presentation
- The 73rd Annial Meeting of the Japan Radiological Society, Apr. 2014, Japanese, The Japan Radiological Society, 横浜、パシフィコ横浜, We retrospectively reviewed the neurological symptom upon intracranial recurrence after whole brain radiotherapy. Patients who had metastatic lesions in the eloquent area had a tendency to show more severe neurological symptom. We propose larger radiation dose to the eloquent area leisons may be beneficial to preserve those patient neurological function, Domestic conferenceRetrospective analysis of whole brain radiotherapy for brain metastasesPoster presentation
- 第73回日本医学放射線学会, Apr. 2014, Japanese, 日本医学放射線学会, 横浜, Domestic conferenceRetrospective analysis of risk factors influencing survival and gait disturbance in patients with spinal metastasesOral presentation
- The 73rd Annial Meeting of the Japan Radiological Society, Apr. 2014, Japanese, The Japan Radiological Society, 横浜、パシフィコ横浜, The purpose of this study was to compare the risk of HT in squamous cell carcinoma of the head and neck undergoing treatment with CCRT or RT alone at our institution., Domestic conferenceRadiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and NeckPoster presentation
- European Society for Radiotherapy & Oncology 33, Apr. 2014, English, European Society for Radiotherapy & Oncology, Vienna, International conferenceIntra-abdomical space modulated radiotherapy: Safety and efficacy of absorbable spacer in particle therapyPoster presentation
- European Society for Radiotherapy & Oncology 33, Apr. 2014, English, European Society for Radiotherapy & Oncology, Vienna, International conferenceA Novel Radiosensitizer, Monogalactosyl diacylglycerol, Enhanced the Cytotoxic Effects for the Pancreatic CancerPoster presentation
- The 27th Annual Meeting of Japan 3-D Conformal External Beam Radiotherapy Group, Feb. 2014, Japanese, Japan Radiological Society, 東京, [目的] 当院におけるPVTT/IVCTTに対する体幹部定位放射線治療の初期成績について遡及的に検討する。[対象] 2013年4月から10月にかけて体幹部定位放射線治療を施行したPVTT/IVCTT症例13例を対象とした。PTVV9例、IVCTT4例であった。年齢は中央値78歳(44-88歳)、男性10名、女性2名で、放射線治療前のChild-Pugh scoreは5-6点が8例、7-8点が5例、PTV sizeの中央値は34.5ml(14.7-111.0ml)であった。治療はCyberknifeによる追尾照射が6例、Truebeamによる呼吸同期が5例、Truebeamによる息止め照射が2例で、照射線量の中央値は50Gy (40-55Gy)、一回線量の中央値は3.6Gy(2.5-12.5Gy)であった。[結果] 経過観察期間の中央値は3ヶ月(1-7, Domestic conference当院におけるPVTT/IVCTTに対する体幹部定位放射線治療の経験Poster presentation
- 第305回公益社団法人日本医学放射線学会関西地方会, Feb. 2014, Japanese, 日本医学放射線学会関西地方会, 大阪(ホテルエルセラーン大阪), 眼球シールドを用いた際の線量分布について検討した, Domestic conference眼瞼周囲皮膚癌に対する新規眼球シールド使用時の線量分布の検討Oral presentation
- 第55回日本婦人科腫瘍学会学術講演会, Dec. 2013, Japanese, 日本婦人科腫瘍学会, 京都府、京都(ウェスティン都ホテル京都), Domestic conference高齢子宮頸癌患者に対する根治的放射線治療の経験Public symposium
- 第305回公益社団法人日本医学放射線学会関西地方会, Nov. 2013, Japanese, 日本医学放射線学会関西地方会, 大阪(ブリーゼプラザ), Domestic conference頭頸部癌に対するセツキシマブ併用放射線治療の初期経験Oral presentation
- 第54回関西若手放射線治療研究会, Nov. 2013, Japanese, 関西若手放射線治療研究会, 大阪(大阪狭山市), 眼球シールドによって放射線障害を低減しえた眼瞼周囲皮膚癌の2例, Domestic conference眼球シールドによって放射線障害を低減しえた眼瞼周囲皮膚癌の2例Oral presentation
- 日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森(ホテル青森、リンクステーションホール青森), Domestic conference放射線療法後に長期経過観察した上咽頭癌症例における晩期有害反応の検討Oral presentation
- 日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森(ホテル青森、リンクステーションホール青森), Domestic conference転移性脳腫瘍に対する全脳照射の検討Poster presentation
- 日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森(ホテル青森、リンクステーションホール青森), Domestic conference中・下咽頭扁平上皮癌に対する放射線治療後の甲状腺機能低下症に関する検討Oral presentation
- 日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森(ホテル青森、リンクステーションホール青森), Domestic conference脊椎転移による脊椎損傷リスクの検討Poster presentation
- 日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森(ホテル青森、リンクステーションホール青森), Domestic conference小児Gliomaに対する放射線治療の経験Poster presentation
- 日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森(ホテル青森、リンクステーションホール青森), Domestic conferenceT1/2声門上癌に対する放射線治療成績の検討Oral presentation
- 日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森(ホテル青森、リンクステーションホール青森), Domestic conferenceSalvage radiotherapy for patients with PSA failure after radical prostatectomyPoster presentation
- 55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, International conferenceRadiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: Comparison between Concurrent Chemoradiotherapy and Radiation Therapy AlonePoster presentation
- 55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, International conferenceNormal tissue tolerance of microplanar beam X-ray : A long-term observationPoster presentation
- 55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, Because of the rarity, a standard treatment for the adult vascular malformation occurred outsides the scalp has not been established. In our institution, the fractionated radiotherapy was successfully applied to the adult vascular malformation of the abdomen, vertebra, and head and neck regions. Here, we retrospectively evaluated our experience and propose a standard of care of, International conferenceImpact of Symptom Rescue by Fractionated Radiotherapy for Rare Angiogenetic Neoplasm of the Abdomen, Vertebra, and Head and Neck RegionsPoster presentation
- 55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, The effect of postoperative radiation treatment (PORT) for facial nerve reconstruction is not fully investigated. The purpose of this study is to evaluate the outcomes of patients treated with the combination of surgery and PORT.Between 2000 and 2009, 27 patients with parotid gland carcinomas were treated with curative surgery and PORT. Nineteen patients received facial nerve s, International conferenceFunctional outcomes of the facial nerve after post operative radiation therapy for high risk parotid gland malignancies underwent radical surgery with facial nerve resection and reconstructive surgery.Poster presentation
- 55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, Most of the recurrences after radical prostatectomy (RP) are detected only by a rise in the prostate-specific antigen (PSA) level without a radiographic recurrence site. For such men it is unknown whether salvage radiotherapy (SRT) to the prostate bed confers a survival benefit compared with systemic therapy. The standard treatment for PSA failure after RP has not yet been dete, International conferenceEfficacy of Salvage Radiotherapy in Men with Biochemical Recurrence After Radical Prostatectomy: A Comparison with Endocrine TherapyPoster presentation
- 55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, MGDG, a major chloroplast membrane galactolipid extracted from spinach, has been reported as a potent inhibitor of DNA replication and repair. The purpose of the current study is to test whether the MGDG might increase the cytotoxic effects of GEM or radiotherapy (IR) in vitro and in vivo by using human pancreas cancer cell lines., International conferenceA Novel Radiosensitizor of the Functional Food Component, Monogalactosyl diacylglycerol (MGDG) from Spinach, Enhanced the Cytotoxic Effects for the Pancreatic Cancer In Vitro and In VivoPoster presentation
- 55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, International conferenceA Novel method of Radioprotection for the Gastointestinal System: Efficacy of the Reduced form of Coenzyme Q10.Poster presentation
- 第38回神戸放射線腫瘍懇話会, Aug. 2013, Japanese, 神戸放射線腫瘍懇話会, 神戸、兵庫(神戸大学医学部附属病院), Domestic conference頭頸部IMRTの共通プロトコール化と共同研究向けてOral presentation
- 第53回JROG, Jul. 2013, Japanese, JROG, 神戸、兵庫(神戸低侵襲がん医療センター), Domestic conference髄膜腫に対する放射線治療の経験Oral presentation
- 第304回公益社団法人日本医学放射線学会関西地方会(第376回レントゲンアーベント), Jun. 2013, Japanese, 公益社団法人日本医学放射線学会関西地方会, 大阪、ホテルエルセラーン大阪, Domestic conference鼻腔腫瘍の治療計画における不均質補正の影響Oral presentation
- 第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京(京王プラザホテル), Domestic conference鼻腔原発NK/T細胞リンパ腫に対する放射線治療経験Poster presentation
- 第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京(京王プラザホテル), Domestic conference頭頸部扁平上皮癌に対する放射線治療後の甲状腺機能低下症に関する検討Poster presentation
- 第304回公益社団法人日本医学放射線学会関西地方会(第376回レントゲンアーベント), Jun. 2013, Japanese, 公益社団法人日本医学放射線学会関西地方会, 大阪、ホテルエルセラーン大阪, Domestic conference頭頚部傍神経節腫に対する放射線治療の経験Oral presentation
- 第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京(京王プラザホテル), Domestic conference当院におけるT3喉頭癌の放射線治療の経験Oral presentation
- 第304回公益社団法人日本医学放射線学会関西地方会(第376回レントゲンアーベント), Jun. 2013, Japanese, 公益社団法人日本医学放射線学会関西地方会, 大阪、ホテルエルセラーン大阪, Domestic conference前立腺全摘術後のPSA再発に対する救済放射線治療の検討Oral presentation
- 第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京(京王プラザホテル), Domestic conference進行舌癌に対する術後放射線治療の経験Poster presentation
- 第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京(京王プラザホテル), Domestic conference耳下腺癌/顎下腺癌術後症例に対する放射線治療の検討Poster presentation
- 第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京(京王プラザホテル), Domestic conference甲状腺原発MALTリンパ腫の治療経験Poster presentation
- 第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京(京王プラザホテル), Domestic conferenceT1/2声門上癌に対する放射線治療成績の検討Poster presentation
- 第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京(京王プラザホテル), Domestic conference5年以上経過観察した上咽頭癌症例に関する放射線療法の晩期有害反応の検討Oral presentation
- 37th Annual MD Anderson Radiation Oncology/Gilbert H. Fletcher Society Meeting, Apr. 2013, English, MD Anderson Radiation Oncology/Gilbert H. Fletcher Society, Kyoto, Japan, International conferenceRadiotherapy for Japanese Elderly Patients with Cervical CancerPoster presentation
- 第17回兵庫粒子線治療研究会のご案内, Mar. 2013, Japanese, 兵庫粒子線治療研究会, 兵庫(生田神社会館), 【目的】重要臓器と近接しているために粒子線・放射線治療が難しい疾患に対する新たな治療法の開発のため、スペーサーをマウス腹部に留置し、毒性を含む生物学的反応とスペーサーの有用性を検討する。【方法】スペーサーをマウス腹部に留置し、一定の観察期間後、スペーサーが生体に及ぼす毒性に関して全血を採取し生化学検査により評価した。また、スペーサーを留置したマウスに対して炭素線を用いた照射実験を行い、スペーサーの有用性を検討した。【結果】採血によるスペーサーの毒性評価では、肝臓、腎臓、膵臓など主要臓器機能に明らかな異常値は認められなかったが、採取可能な血液が少ないことから、無毒性という確定できなかった。照射後の体重の変化を検討したが、スペーサーによる腸管への線量低減効果が示唆された。組織学的検討ではスペーサー周囲に炎症細胞浸潤が認められた。, Domestic conference新規体内吸収性PGA spacerの基礎研究開発Oral presentation
- European Congress of Radiology(ECR, Mar. 2013, English, European Society of Radiology, Austria,Vienna, Purpose/Objective(s): To assess the efficacy of radiation therapy for Squamous cell carcinomas of oropharynx at Kobe University Hospital retrospectively.Materials/Methods: Between July 2000 and March 2011, 98 patients with squamous cell carcinomas of the, International conferenceTen Year Experience with Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of OropharynxPoster presentation
- European Congress of Radiology(ECR, Mar. 2013, English, European Society of Radiology, Austria,Vienna, Purpose: The purpose of this study was to evaluate the survival outcomes for Japanese elderly patients with cervical cancer treated with radiotherapy (RT).Methods: Fifty-five patients ≥ 75 years old with cervical cancer who were treated with RT were evaluated. Of these 55 patients, 30 were classified as FIGO stage I or II and 25 as stage III or IVA. Two patients had adenocarcin, International conferenceRadiotherapy for Japanese elderly patients with cervical cancerPoster presentation
- 第303回日本医学放射線学会関西地方会(第375回レントゲンアーベント), Feb. 2013, Japanese, 日本医学放射線学会関西地方会, 大阪(ブリーゼプラザ小ホール), Domestic conference特発性眼窩炎症に対する治療経験Oral presentation
- 第303回日本医学放射線学会関西地方会(第375回レントゲンアーベント), Feb. 2013, Japanese, 日本医学放射線学会関西地方会, 大阪(ブリーゼプラザ小ホール), Domestic conference成人型頭蓋外血管腫・血管奇形の放射線治療Oral presentation
- 第303回日本医学放射線学会関西地方会(第375回レントゲンアーベント), Feb. 2013, Japanese, 日本医学放射線学会関西地方会, 大阪(ブリーゼプラザ小ホール), Domestic conference若年者のgliomaに対する放射線治療の経験Oral presentation
- 日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京(東京国際フォーラム), Domestic conference鼻腔原発NK/T 細胞リンパ腫に対する放射線治療経験Poster presentation
- 日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京(東京国際フォーラム), 【目的】当院における中咽頭扁平上皮癌の放射線治療成績を遡及的に検討する。【方法】2000年7月から2011年1月までに当院にて中咽頭扁平上皮癌と診断され、放射線治療を施行した96例を対象とした。年齢の中央値は62歳(31-96歳)、男:女=80:16であった。亜部位は前壁:側壁:後壁:上壁=24:57:3:12、進展度はT1:T2:T3:T4a:T4b=6:54:17:10:5、N0:N1:N2a:N2b:N2c:N3=18:14:6:32:17:9であった。手術は13例に施行され、化学療法の併用は81例(同時併用76例)、処方線量の中央値は70Gy(60-70.8Gy)であった。【結果】経過観察期間の中央値は25.5か月(3-141か月)。3年の全生存割合は76%で、無再発生存割合は66%、局所領域制御割合は70%であった。病期別の3年全生存割合は, Domestic conference当院における中咽頭扁平上皮癌に対する放射線治療成績Poster presentation
- 日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京(東京国際フォーラム), 【目的】2005-2009年の間に治療された脳リンパ腫304例のデータを解析し、以前に収集した1985-2004年の739例と比較した。【方法】調査の対象は放射線治療を受けた組織確定例で、治療悲完遂例も含めた。以前と同様の調査票を用いた。【結果】患者、腫瘍の特徴に関する主な変化は、患者年齢の上昇(2005-2009年について、中央値68歳)、良PS症例の増加(0-2が75%)、腫瘍多発例の増加(全症例の52%)であった。治療に関する主な変化は、後半切除術の減少(全症例の23%)、総線量、全脳線量の減少(平均46.9/33.8Gy)、含メトトレキサーと(MTX)化学療法の増加(全症例の64%)であった。患者の5生率は、18%、59%、49%、53%であった。全期間を通じて、部分脳照射で治療された患者の5生率は37%であったが、全脳照射を受けた患者は24, Domestic conference中枢神経原発悪性リンパ腫の全国調査結果:2005-2009 年と1985-2004 年のデータの比較Oral presentation
- 日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京(東京国際フォーラム), Physicaly and biological experimental outcomes of originally established absorbant spacer was explained, Domestic conference大型動物を用いた体内吸収性スペーサーの長期安全性の検討Oral presentation
- 日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京(東京国際フォーラム), 目的 2001年から2010年に神戸大学医学部附属病院において放射線治療が施行された高齢頭頸部癌患者に関する遡及的な検討を行う。対象 75歳以上で根治、術後、及び姑息的局所コントロール目的も含め頸部照射が施行された症例を対象とした。これらについて、患者数の推移や、治療の完遂率等を調査した。結果 症例数は221例であった。うち姑息的局所コントロール目的での照射が46例(21%)であった。年齢は中央値78歳 (75-96歳)で、その内80歳以上は80人で全体の全体の36%であった。男性が164例、女性が58例であった。組織型では扁平上皮癌が最も多く186例、悪性リンパ腫が次いで多く21例、以下癌(分類不能)が6例、腺癌、腺様嚢胞癌が4例ずつであった。原発部位は口腔36例、鼻腔・副鼻腔32例、咽頭57例、喉頭66例、その他が30例と喉頭癌が最も多かった。患, Domestic conference高齢頭頸部癌患者に対する放射線治療の経験 −10 年間の検討−Oral presentation
- 日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京(東京国際フォーラム), 顎下腺癌術後症例に対して放射線療法を施行し、良好な治療成績を得た。, Domestic conference顎下腺癌に対する術後放射線療法の検討Poster presentation
- 日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京(東京国際フォーラム), Domestic conferenceホウレンソウから抽出した機能性糖脂質MGDG を用いた新規放射線増感剤の研究Poster presentation
- 日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京(東京国際フォーラム), Domestic conferenceRedox 制御を介した放射線腸管障害抑制法の基礎的検討Oral presentation
- 日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京(東京国際フォーラム), Domestic conferenceOutcomes of particle beam radiation therapy for lung metastasesPoster presentation
- 日本医学放射線学会関西地方会(第374回レントゲンアーベント), Nov. 2012, Japanese, 日本医学放射線学会関西地方会(第374回レントゲンアーベント), 大阪府大阪市クリスタルタワー20階A会議室, 目的: HIV陽性患者に発生した悪性腫瘍3例の治療経験を報告する。症例1:37歳男性 PCNSL疑い。症例2:56歳女性 PCNSL。例3:54歳男性 中咽頭癌。症例1はHAART+。照射(30Gy/10fr)、症例2はHAART+。全脳照射(36Gy/20fr)、症例3はHAART+全頸部・boost照射(70.2Gy/39fr)を施行。3症例とも非感染者と比較して有害反応の早期出現や重篤化は見られず、治療は完遂できた。放射線治療はHIV陽性患者の悪性腫瘍に対する有用な治療手段であると考えるが、線量・照射範囲は慎重に決定する必要がある。まとめ:HIV陽性患者に発生した悪性腫瘍に対する治療経験について報告した。, Domestic conferenceHIV陽性患者に発生した悪性腫瘍に対する放射線治療の経験Oral presentation
- 98th Scientific Assembly and Annual Meeting of The Radiological Society of North America, Nov. 2012, English, The Radiological Society of North America, U.S.A , Chicago, International conferenceCombination Efficacy of MGMT Promoter Methylation Status and MIB-1 Labeling Index for Pattern of Recurrence in Glioblastoma Treated with Multimodal TreatmentPoster presentation
- 54th ASTRO Annual Meeting, Oct. 2012, English, ASTRO, U.S.A , Boston, Purpose/Objective(s): The popularization of computed tomography (CT) in clinical practice has increased the frequency of discovery of nodular ground-glass opacity (GGO). Surgery has been regarded as the general treatment for tumors composed of mainly GGO, International conferenceStereotactic Body Radiation Therapy in 95 Patients With Lung Tumors Composed of Ground-glass Opacity (GGO): Results of a Retrospective Multicenter StudyOral presentation
- 54th ASTRO Annual Meeting, Oct. 2012, English, ASTRO, U.S.A , Boston, Purpose/Objective(s): The JASTRO CNS Lymphoma Study Group has conducted nationwide surveys of PCNSL patients seen at radiation therapy departments in Japan. Data on 739 patients treated between 1985 and 2004 were published. In a new survey, we have collec, International conferencePrimary Central Nervous System Lymphoma (PCNSL) Treated by Radiation Therapy: A Nationwide Survey of 2005-2009 Patients and Comparison With 1985-2004 DataPoster presentation
- 54th ASTRO Annual Meeting, Oct. 2012, English, ASTRO, U.S.A , Boston, International conferencePatterns of Local Recurrence and Metachronous Malignancy Following Radiation Therapy for Stage I or II Hypopharyngeal Carcinoma: Role of Close Observation and Multidisciplinary ApproachPoster presentation
- 54th ASTRO Annual Meeting, Oct. 2012, English, ASTRO, U.S.A , Boston, Purpose/Objective(s): Particle beams, such as proton and carbon ion beams, have demonstrated an increase in energy deposition with a penetration depth up to a sharp maximum at the end of their range: the so-called Bragg peak phenomenon. With current metho, International conferenceEfficacy of Surgically Implanted Flexible Spacer in Particle Therapy: A novel strategy Making Temporal Space between Tumor and Adjacent OrgansPoster presentation
- 第37回神戸放射線腫瘍懇話会, Aug. 2012, Japanese, 神戸放射線腫瘍懇話会, 神戸(神戸大学医学部), Domestic conference食道小細胞癌に対する治療経験Oral presentation
- The 14th Asian Oceanian Congress of Radiology, Aug. 2012, English, The 14th Asian Oceanian Congress of Radiology, Australia,Sydney, Purpose: The purpose of this study is to evaluate the outcomes of radiation therapy for brainstem gliomas both in children and adults.Methods: Between 1990 and 2010, 25 patients with brainstem gliomas were treated with radiotherapy. Thirteen were children with a median age of 8 years old (Range: 2 – 18 years old) and 12 were adults with a median age of 56 years old (Range: 29 –, International conferenceRadiation therapy for brainstem gliomas in children and adultsPoster presentation
- 日本医学放射線学会関西地方会(第373回レントゲンアーベント), Jul. 2012, Japanese, 日本医学放射線学会関西地方会(第373回レントゲンアーベント), 大阪府大阪市(ホテルエルセラーン大阪), Domestic conference喉頭原発悪性リンパ腫に対する放射線治療の経験Oral presentation
- 日本医学放射線学会関西地方会(第373回レントゲンアーベント), Jul. 2012, Japanese, 日本医学放射線学会関西地方会(第373回レントゲンアーベント), 大阪府大阪市ホテルエルセラーン大阪, 【目的】我々は過酸化チタンナノ粒子がX線照射により活性酸素種を発生することを見出した。本研究では担癌マウスを用いて同ナノ粒子の放射線増感効果を検討した。【方法】ヒト膵癌細胞MIAPaCa-2を移植したヌードマウスを用いて、ナノ粒子分散液の局注にて、無治療群、ナノ粒子単独群、X線単独群、併用治療群の4群の腫瘍増殖抑制効果を判定した。【結果】治療後43日間の観察期間で、併用群ではX線単独群と比べて有意な腫瘍増殖抑制を認めた。【結論】過酸化チタンナノ粒子の放射線増感効果が判明した。同併用療法が新しい治療法になり得る可能性が示唆された。, Domestic conference過酸化チタンナノ粒子による放射線増感の検討Oral presentation
- The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県(広島国際会議場), International conferenceTherapeutic Strategies aimed at Laryngeal Preservation of T1-T3N0 Glottic Laryngeal cancerPoster presentation
- The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県(広島国際会議場), Efficacly of originally established absorbant spacer was explained, International conferenceSurgically Implanted Flexible Spacer in Particle Therapy:Making Temporal Space between Tumor and Adjacent Organs!Poster presentation
- The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県(広島国際会議場), Purpose: To assess the efficacy radiation therapy for Squamous cell carcinomas of oropharynx at Kobe University Hospital retrospectively.Methods: Between September 1990 and January 2011, 138 patients with Squamous cell carcinomas of the oropharynx were tr, International conferenceRadiotherapy for Squamous Cell Carcinomas of OropharynxPoster presentation
- The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県(広島国際会議場), Purpose: The purpose of this study is to evaluate the outcomes of radiation therapy for brainstem gliomas both in children and adults.Methods: Between 1990 and 2010, 25 patients with brainstem gliomas were treated with radiotherapy. Thirteen were children, International conferenceRadiation therapy for brainstem gliomas in children and adultsPoster presentation
- The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県(広島国際会議場), Postoperative radiotherapy for carcinomas of the parotid gland showed favorable local and regional control., International conferencePostoperative radiotherapy for the malignant tumors of the parotid glandPoster presentation
- The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県(広島国際会議場), International conferenceImpact of MGDG Promoter Methylation Status and MIB-1 Labeling Index on Recurrence Pattern after Multimodal Treatment in GlioblastomaPoster presentation
- The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県(広島国際会議場), International conferenceClinical results of Particle beam radiation therapy for Lung metastasesPoster presentation
- The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県(広島国際会議場), International conferenceChemoradiotherapy in Patients with Locally Advanced Unresectable Esophageal Squamous Cell CarcinomaPoster presentation
- The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県(広島国際会議場), Background/Purpose: Monogalactosyldiacylglycerol (MGDG), a major chloroplast membrane galactolipid extracted from spinach, has been reported as a potent inhibitor of DNA replication and repair. The purpose of the current study is to test whether the MGDG, International conferenceA Novel Radiosensitizor, Monogalactosyldiacyglycerol(MDGD)from Spinach, Enhanced the Cytotoxicity of Radiotherapy to Pancreatic CancerPoster presentation
- 第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市(島根県民会館), Domestic conference鼻腔悪性黒色腫に対する大線量小分割法放射線治療の経験Poster presentation
- 第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市(島根県民会館), 【目的】当院における中咽頭扁平上皮癌の放射線治療成績を遡及的に検討する。【方法】1990年9月から2011年1月までに当院にて中咽頭扁平上皮癌と診断され、放射線治療を施行した138例を対象とした。年齢の中央値は61歳(31-96歳)、男:女=117:21、経過観察期間の中央値は27か月(3-209か月)であった。亜部位は前壁:側壁:後壁:上壁=39:77:4:18、進展度はT1:T2:T3:T4=8:71:26:33、N0:N1:N2:N3=23:21:80:14であった。手術は33例に施行され、化学療法の併用は112例(同時併用91例)、処方線量の中央値は70Gy(50-76.8Gy)であった。【結果】経過観察期間の中央値は27か月(3-209か月)。3年の全生存割合は73%で、無再発生存割合は65%、局所領域制御割合は73%であった。病期別の3年, Domestic conference当院における中咽頭扁平上皮癌に対する放射線治療成績Oral presentation
- 第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市(島根県民会館), 目的 2001年から2010年に神戸大学医学部附属病院において放射線治療が施行された高齢頭頸部癌患者に関する遡及的な検討を行う。対象 75歳以上で根治、術後、及び姑息的局所コントロール目的も含め頸部照射が施行された症例を対象とした。これらについて、患者数の推移や、治療の完遂率等を調査した。結果 症例数は221例であった。うち姑息的局所コントロール目的での照射が46例(21%)であった。年齢は中央値78歳 (75-96歳)で、その内80歳以上は80人で全体の全体の36%であった。男性が164例、女性が58例であった。組織型では扁平上皮癌が最も多く186例、悪性リンパ腫が次いで多く21例、以下癌(分類不能)が6例、腺癌、腺様嚢胞癌が4例ずつであった。原発部位は口腔36例、鼻腔・副鼻腔32例、咽頭57例、喉頭66例、その他が30例と喉頭癌が最も多かった。患, Domestic conference高齢頭頸部癌患者に対する放射線治療の経験-10年間の検討-Poster presentation
- 第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市(島根県民会館), Efficacy of radiotherapy to Vascular oriented neoplasm was explained, Domestic conference顔面・頭頸部に発生した血管原性腫瘍に対する放射線治療の経験Oral presentation
- 第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市(島根県民会館), 顎下腺癌術後症例に対して放射線療法を施行し、良好な治療成績を得た。, Domestic conference顎下腺癌に対する放射線療法の経験Poster presentation
- 第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市(島根県民会館), Domestic conferenceT1-T3NO声門癌の喉頭温存を目指した治療方針の検討Oral presentation
- 第71回日本医学放射線学会総会, Apr. 2012, Japanese, 日本医学放射線学会, 横浜(パシフィコ横浜), 目的:神戸大学病院での脳幹部腫瘍に対する放射線治療の経験について報告する。対象と方法:1990年から2010年にかけて放射線治療が施行された25例。うち小児13例、成人12例であり、年齢は小児が中央値8歳(2-18歳)、成人が56歳(29-75歳)であった。発生部位は橋を含むものが20例、延髄が3例、中脳が2例であった。組織学的診断が得られたのは10例で全例が神経膠腫系であった。うち3例が小児で、Grade2が1例、Grade3が2例であった。残り7例が成人で、Grade1が1例、Grade3が2例、Grade4が4例であった。放射線治療は1回線量1.8-2.0Gyで、総線量は中央値56Gy(50-70Gy)であった。また総治療期間は中央値43日(37-49日)であった。併用療法としてテモゾロマイドが25例中10例に投与されていた。結果:小児では13, Domestic conference脳幹部Gliomaに対する放射線治療の経験Others
- 第71回日本医学放射線学会総会, Apr. 2012, Japanese, 日本医学放射線学会, 横浜(パシフィコ横浜), Domestic conference転移性肺腫瘍に対する粒子線治療成績の検討Oral presentation
- 第71回日本医学放射線学会総会, Apr. 2012, Japanese, 日本医学放射線学会, 横浜(パシフィコ横浜), 耳下腺癌術後症例に対して放射線療法を施行し、良好な局所制御を得た。, Domestic conference耳下腺癌術後症例に対する放射線療法の経験Others
- 第71回日本医学放射線学会総会, Apr. 2012, Japanese, 日本医学放射線学会, 横浜(パシフィコ横浜), Domestic conferenceT1-T3NO声門癌の喉頭温存を目指した治療方針の検討Oral presentation
- 第300回日本医学放射線学会関西地方会(第372回レントゲンアーベント), Mar. 2012, Japanese, 日本医学放射線学会関西地方会, ブリーゼプラザ7階小ホール(大阪市), Domestic conference脳幹部腫瘍に対する放射線治療の経験Oral presentation
- 第16回 兵庫粒子線治療研究会, Mar. 2012, Japanese, 神戸, Domestic conference「新開発した生体吸収性スペーサーの基礎的検討」Oral presentation
- 第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル(神戸市), Domestic conference頭皮原発血管肉腫のRecursive partitioning analysis (RPA)の検討Oral presentation
- 第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル(神戸市), Domestic conference当院における前立腺癌小線源治療(ヨード永久刺入)の経験、現状についてOral presentation
- 第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル(神戸市), Domestic conference低悪性度神経膠腫に対する放射線治療の経験Oral presentation
- 第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル(神戸市), Domestic conference体内スペーサーの生体反応と線量分布最適化の研究Oral presentation
- 第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル(神戸市), Domestic conference線源種類による前立腺永久刺入療法治療計画への影響に関する検討Oral presentation
- 第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル(神戸市), Domestic conference上顎洞平上皮癌に対する放射線治療成績Oral presentation
- 第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル(神戸市), Domestic conference耳下腺癌術後症例に対する放射線療法の経験Oral presentation
- 第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル(神戸市), Domestic conference再建遊離空腸に対する術後(化学)放射線療法の検討Oral presentation
- 第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル(神戸市), Domestic conference過酸化チタンナノ粒子を用いた放射線感受性増感効果の基礎的研究Oral presentation
- 第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル(神戸市), Domestic conferenceマイクロスリットビームX線照射に対する正常脳耐容線量の検討Oral presentation
- 第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル(神戸市), Domestic conferenceT1(bulky)ーT3NO喉頭癌の喉頭温存を目指した治療方法の検討Oral presentation
- 第49回日本癌治療学会, Oct. 2011, Japanese, 日本癌治療学会, 名古屋国際会議場(名古屋市), Domestic conference脳幹部腫瘍に対する放射線治療の経験Oral presentation
- 第49回日本癌治療学会, Oct. 2011, Japanese, 日本癌治療学会, 名古屋国際会議場(名古屋市), Domestic conference精巣腫瘍(seminoma)に対する放射線治療の経験Oral presentation
- 第49回日本癌治療学会, Oct. 2011, Japanese, 日本癌治療学会, 名古屋国際会議場(名古屋市), Domestic conference上顎洞扁平上皮癌に対する放射線治療成績Oral presentation
- 第73回日本血液学会学術集会, Oct. 2011, Japanese, 日本血液学会, 愛知, Domestic conferenceRituximab prior to local radiotherapy prevents from relapse in ocular adnexal MALT lymphomaOral presentation
- 53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conferenceRadiation Therapy For Brain Stem Gliomas In Children And AdultsOral presentation
- 53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conferenceProton Beam Therapy and Carbon-ion Radiotherapy for T2a-T2bN0M0 Non-small Cell Lung CancerOral presentation
- 53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conferenceMicroplanar Beams Radiation: Is Brain Really A Serial Organ?Oral presentation
- 53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conferenceLong-term Outcome and Patterns of Failure in Primary Ocular Adnexal MALT Lymphoma Treated with RadiotherapyOral presentation
- 53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conferenceDosimetric Analysis of Patterns of Failure for High-grade Glioma with Multimodality Treatment: Relationship to MIB-1 Labeling IndexOral presentation
- 53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conferenceCombined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus: A Retrospective StudyOral presentation
- 16th ECCO, Sep. 2011, English, ECCO, ストックホルム, ドイツ, International conferenceRadiotherapy for Elderly Patients With Cervical CancerOral presentation
- 16th ECCO, Sep. 2011, English, ECCO, ストックホルム, ドイツ, International conferenceCombined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus - a Retrospective StudyOral presentation
- 第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知(名古屋市), Domestic conference遊離空腸再建後の高リスク頭頸部癌に対する術後放射線治療の検討Oral presentation
- 第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知(名古屋市), Domestic conference頭頸部皮膚血管肉腫に対するRecursive partitioning analysis(RPA)の検討Oral presentation
- 第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知(名古屋市), Domestic conference頭頸部腺様嚢胞癌に対する粒子線(陽子線・炭素線)単独治療成績Oral presentation
- 第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知(名古屋市), Domestic conference頭蓋底浸潤を認めた頭頸部癌に対する粒子線治療成績Oral presentation
- 第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知(名古屋市), Domestic conference当科における顎下腺癌手術症例の検討Oral presentation
- 第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知(名古屋市), Domestic conference上顎洞扁平上皮癌に対する放射線治療成績Oral presentation
- 第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知(名古屋市), Domestic conference耳下腺癌術後症例に対する放射線治療の経験Oral presentation
- 第298回日本医学放射線学会関西地方会, Jun. 2011, Japanese, 大阪, Domestic conference局所進行切除不能食道癌(T4/M1LYM)に対する化学放射線療法Oral presentation
- 第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知(名古屋市), Domestic conference局所進行外耳道扁平上皮癌に対する3剤(TPF)併用化学放射線療法の経験Oral presentation
- 第70回日本医学放射線学会総会, May 2011, Japanese, 日本医学放射線学会, 震災の影響によりWEB開催, Domestic conference鼻腔NK/T細胞性リンパ腫に対する放射線治療の経験Oral presentation
- 第70回日本医学放射線学会総会, May 2011, Japanese, 日本医学放射線学会, 震災の影響によりWEB開催, Domestic conference精巣腫瘍(seminoma)に対する放射線治療の経験Oral presentation
- 第70回日本医学放射線学会総会, May 2011, Japanese, 日本医学放射線学会, 震災の影響によりWEB開催, Domestic conference原発不明頸部リンパ節転移に対する治療経験Oral presentation
- 第70回日本医学放射線学会総会, May 2011, Japanese, 日本医学放射線学会, 震災の影響によりWEB開催, Domestic conference局所進行外耳道扁平上皮癌に対する3剤(TPF)併用化学放射線療法の経験Oral presentation
- 第70回日本医学放射線学会総会, May 2011, Japanese, 日本医学放射線学会, 震災の影響によりWEB開催, Domestic conference1・2期下咽頭癌に対する放射線治療成績の検討Oral presentation
- 第297回 日本医学放射線学会関西地方会, Feb. 2011, Japanese, 大阪(大阪), Domestic conference頭頚部腺様嚢胞癌に対する放射線治療の経験Oral presentation
- 第36回神戸放射線腫瘍懇話会, 2011, Japanese, 神戸放射線腫瘍懇話会, 神戸大学医学部附属病院(神戸市), Domestic conference神戸大学における前立腺癌小線源治療-2年半の経験についての検討-Oral presentation
- 第36回神戸放射線腫瘍懇話会, 2011, Japanese, 神戸放射線腫瘍懇話会, 神戸大学医学部附属病院(神戸市), Domestic conference吸収性スペーサーの新規開発における基礎的検討Oral presentation
- 日本繊維機械学会 秋季セミナー, Nov. 2010, Japanese, Domestic conference乳がん患者の放射線治療衣の開発Poster presentation
- 日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conference頭頸部腺様嚢胞癌に対する粒子線(陽子線・炭素線)治療Oral presentation
- 第296回日本医学放射線学会関西地方会(第368回レントゲンアーベント), Nov. 2010, Japanese, 大阪医科大学, Domestic conference当院における食道癌放射線治療の遡及的検討Oral presentation
- 日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conference当院における食道癌に対する化学放射線治療の遡及的検討Oral presentation
- 日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conference当院で放射線治療を施行した悪性神経膠腫の再発形式に関する検討Oral presentation
- 日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conference局所進行外自動扁平上皮癌に対する3剤(TPF)併用化学放射線療法の経験Oral presentation
- 日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conference眼付属器MALTリンパ腫の放射線治療成績の検討Oral presentation
- 日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conferenceゲムシタビン・放射線併用療法のおけるオートファジーの役割に関する基礎的研究Oral presentation
- 日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conference1・2期下咽頭癌に対する放射線治療成績の検討Oral presentation
- 52nd ASTRO, Oct. 2010, English, サンディエゴ, アメリカ, International conferenceRadiotherapy for Elderly Patients with Cervical CancerOral presentation
- 52nd ASTRO, Oct. 2010, English, サンディエゴ, アメリカ, International conferenceParticle-BeamRadiation Therapy for Skull Base Chordomas:A Retrospective StudyOral presentation
- 第48回日本癌治療学会学術大会, Oct. 2010, Japanese, 京都, Domestic conferenceI/II期子宮頚癌に対する 根治的放射線治療の遡及的検討Oral presentation
- 第48回日本癌治療学会学術集会, Oct. 2010, Japanese, 日本癌治療学会, 京都, Domestic conference1/2 期子宮頸癌に対する根治的放射線治療の遡及的解析Oral presentation
- 第35回 神戸放射線腫瘍懇話会, Aug. 2010, Japanese, 神戸, Domestic conference臨床的肺癌に対する粒子線治療成績 -stageI症例における遡及的解析-Oral presentation
- 第35回 神戸放射線腫瘍懇話会, Aug. 2010, Japanese, 神戸, Domestic conference原発不明癌頸部リンパ節転移に対する治療経験Oral presentation
- 第35回 神戸放射線腫瘍懇話会, Aug. 2010, Japanese, 神戸, Domestic conferenceSpring-8の白色X線を用いた Microslit beam irradiationの基礎的研究の準備状況と将来展望Oral presentation
- 第35回 神戸放射線腫瘍懇話会, Aug. 2010, Japanese, 神戸, Domestic conferenceCBCTによる吸収線量が前立腺癌放射線治療に及ぼす影響Oral presentation
- 第295回日本医学放射線学会関西地方会, Jul. 2010, Japanese, 大阪, Domestic conference眼付属器リンパ腫の放射線治療成績の検討Oral presentation
- 平成22年度科学研究費補助金 基盤研究(A)「早期の癌に対する標準的放射線治療方法確立と適応決定に関する研究」 第1回全体会議, Jul. 2010, Japanese, 松島, Domestic conference眼付属器MALTリンパ腫に対する放射線治療成績の検討Oral presentation
- 第295回日本医学放射線学会関西地方会, Jul. 2010, Japanese, 大阪, Domestic conference拡散テンソル画像を用いた悪性繰りおーマに対する強度変調放射線治療の検討Oral presentation
- 第48回日本婦人科腫瘍学会学術集会, Jul. 2010, Japanese, 日本婦人科腫瘍学会, つくば, Domestic conference1/2 期子宮頸癌に対する根治的放射線治療の遡及的解析Oral presentation
- 第34回頭頚部癌学会, Jun. 2010, Japanese, 東京(新宿), Domestic conference嗅神経芽細胞腫に対する粒子線治療成績Oral presentation
- 第34回頭頚部癌学会, Jun. 2010, Japanese, 東京(新宿), Domestic conference放射線治療が施行された喉頭悪性リンパ腫の3例Oral presentation
- 第34回頭頚部癌学会, Jun. 2010, Japanese, 東京(新宿), Domestic conference当院における頭頚部腺様囊胞腺癌に対する術後放射線治療の遡及的検討Oral presentation
- 第34回頭頚部癌学会, Jun. 2010, Japanese, 東京(新宿), Domestic conference当院における中咽頭癌の放射線治療成績Oral presentation
- 第34回頭頚部癌学会, Jun. 2010, Japanese, 東京(新宿), Domestic conference原発不明癌頚部リンパ節転移に対する治療経験Oral presentation
- 第34回頭頚部癌学会, Jun. 2010, Japanese, 東京(新宿), Domestic conference局所進行上顎洞扁平上皮癌に対する粒子線(陽子線・炭素線)治療Oral presentation
- 第34回頭頚部癌学会, Jun. 2010, Japanese, 東京(新宿), Domestic conference下咽頭癌に対する術後放射線治療の遡及的検討Oral presentation
- 第47回JROG, May 2010, Japanese, 大阪, Domestic conference鼻腔NK/T cell lymphomaに対する放射線治療Oral presentation
- 第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference放射線治療が施行された喉頭原発悪性リンパ腫の3例Oral presentation
- 第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference鼻腔突出型巨大鼻腔腫瘍に対する粒子線治療経験Oral presentation
- 第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference頭蓋内germ cell tumorに対する放射線治療成績Oral presentation
- 第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference頭蓋底脊索腫に対する粒子線治療Oral presentation
- 第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference当院における中枢神経原発悪性リンパ腫に対する放射線治療の遡及的検討Oral presentation
- 第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference高齢子宮頚癌患者に対する放射線治療の経験Oral presentation
- 第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference局所進行下咽頭癌に対する術後照射の遡及的検討Oral presentation
- 第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference肝細胞癌に対する粒子線治療前TACEの有効性の検討Oral presentation
- 第294回日本医学放射線学会関西地方会, Feb. 2010, Japanese, 日本医学放射線学会, 大阪, Domestic conference骨転移痛に対するストロンチウム-89の初期使用経験Oral presentation
- 第294回日本医学放射線学会関西地方会, Feb. 2010, Japanese, 日本医学放射線学会, 大阪, Domestic conference胸部食道癌の治療計画における不均質補正の影響Oral presentation
- 51th ASTRO, Nov. 2009, English, シカゴ, アメリカ, International conferenceParticle Therapy for Sacrococcygeal Chordomas: A Retrospective StudyOral presentation
- 51th ASTRO, Nov. 2009, English, シカゴ, アメリカ, International conferenceParticle Therapy for Bone and Soft Tissue Sarcomas: A Retrospective StudyOral presentation
- 51th ASTRO, Nov. 2009, English, シカゴ, アメリカ, International conferenceNovel Physiological Reaction after Proton Beam Therapy in Patients with Prostate Cancer: Urinary ActivationOral presentation
- 51th ASTRO, Nov. 2009, English, シカゴ, アメリカ, International conferenceHigh-dose Proton Beam Therapy and Carbon-ion Radiotherapy for Stage I Non–small-cell Lung CancerOral presentation
- 第47回日本癌治療学会学術大会, Oct. 2009, Japanese, 日本癌治療学会, 横浜, Domestic conference粒子線治療を選択した骨軟部腫瘍症例の検討Oral presentation
- 第293回日本医学放射線学会関西地方会, Oct. 2009, Japanese, 日本医学放射線学会, 大阪, Domestic conference鼻外突出型巨大鼻腔腫瘍に対する粒子線治療経験Oral presentation
- 第47回日本癌治療学会学術大会, Oct. 2009, Japanese, 日本癌治療学会, 横浜, Domestic conference頭蓋底脊索腫に対する粒子線治療Oral presentation
- 第293回日本医学放射線学会関西地方会, Oct. 2009, Japanese, 日本医学放射線学会, 大阪, Domestic conference当院における中枢神経原発悪性リンパ腫(PCNSL)の放射線治療経験Oral presentation
- 第47回日本癌治療学会学術大会, Oct. 2009, Japanese, 日本癌治療学会, 横浜, Domestic conference聴器扁平上皮癌に対する治療経験Oral presentation
- 15th ECCO, Sep. 2009, English, ベルリン, ドイツ, International conferenceParticle Therapy for Mucosal Malignant Melanoma of the Head and Neck: A retrospective StudyOral presentation
- 48th PTCOG, Sep. 2009, English, ハイデルベルグ, ドイツ, International conferenceParticle Therapy for Bone and Soft Tissue Sarcomas: A Retrospective StudyOral presentation
- 11th WC2009 (the World Congress on Medical Physics and Biomedical Engineering), Sep. 2009, English, ミュンヘン, ドイツ, International conferenceParticle-beam radiation therapy for the tumor of pharyngeal regionOral presentation
- 11th WC2009 (the World Congress on Medical Physics and Biomedical Engineering), Sep. 2009, English, ミュンヘン, ドイツ, International conferenceCurrent status of the HIBMC, providing particle beam radiation therapy for more than 2,600 patients, and the prospects of laser-driven proton radiotherapyOral presentation
- 第34回神戸放射線腫瘍懇話会, Aug. 2009, Japanese, 神戸, Domestic conference胸部食道癌における不均質補正の有無による線量の相違Oral presentation
- 第34回神戸放射線腫瘍懇話会, Aug. 2009, Japanese, 神戸, Domestic conference拡散テンソルを用いた脳腫瘍放射線治療計画の検討Oral presentation
- 第292回日本医学放射線学会関西地方会, Jul. 2009, Japanese, 日本医学放射線学会, 大阪, Domestic conference門脈腫瘍栓(Vp3、Vp4)かつ多発肝内転移を伴う肝細胞癌に対する動注科学療法同時併用粒子線治療の初期経験Oral presentation
- 第48回日本医学放射線学会生物部会学術大会, Jul. 2009, Japanese, 日本医学放射線学会生物部会, 富山, Domestic conference頭頚部癌に対する集学的治療の取り組み中での放射線生物学の役割Oral presentation
- 第292回日本医学放射線学会関西地方会, Jul. 2009, Japanese, 日本医学放射線学会, 大阪, Domestic conference限局型小細胞肺癌に対する科学放射線療法の治療成績Oral presentation
- 第33回日本頭頚部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 札幌, Domestic conference鼻副鼻腔未分化癌10症例の粒子線治療成績Oral presentation
- 第121回関西骨軟部腫瘍研究会(臨床), Jun. 2009, Japanese, 大阪, Domestic conference転移性骨腫瘍に対する粒子線治療成績Oral presentation
- 第33回日本頭頚部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 札幌, Domestic conference口腔悪性腫瘍に対する粒子線治療成績Oral presentation
- 第68回日本医学放射線学会総会, Apr. 2009, Japanese, 日本医学放射線学会, 横浜, Domestic conference粒子線治療後の皮膚炎に対する湿潤療法の初期経験Oral presentation
- 第68回日本医学放射線学会総会, Apr. 2009, Japanese, 日本医学放射線学会, 横浜, Domestic conference転移性肝腫瘍に対する粒子線治療Oral presentation
- 第68回日本医学放射線学会総会, Apr. 2009, Japanese, 日本医学放射線学会, 横浜, Domestic conference加速部分乳房照射における陽子線治療計画とX線治療計画の比較検討Oral presentation
- JROG, Nov. 2008, Japanese, 関西若手放射線治療勉強会, 大阪, Domestic conference仙骨脊索腫に対する粒子線治療経験Oral presentation
- 日本放射線腫瘍学会第21回学術大会, Oct. 2008, Japanese, 日本放射線腫瘍学会, 札幌, Domestic conference頭頸部悪性黒色腫に対する粒子線治療Oral presentation
- 日本放射線腫瘍学会第21回学術大会, Oct. 2008, Japanese, 日本放射線腫瘍学会, 札幌, Domestic conference骨軟部肉腫に対する粒子線治療成績Oral presentation
- 第289回日本医学放射線学会関西地方会, Jun. 2008, Japanese, 日本医学放射線学会, 大阪, Domestic conference転移性肝腫瘍に対する粒子線治療Oral presentation
- 第67回日本医学放射線学会総会, Apr. 2008, Japanese, 日本医学放射線学会, 横浜, Domestic conference頭頸部腺様嚢胞癌に対する粒子線治療:後ろ向き検討Oral presentation
- 第20回日本放射線腫瘍学会, Dec. 2007, Japanese, 日本放射線腫瘍学会, 福岡, Domestic conference視神経近傍頭頚部腫瘍に対する粒子線治療後の視力障害症例の検討Oral presentation
- 第20回日本放射線腫瘍学会, Dec. 2007, Japanese, 日本放射線腫瘍学会, 福岡, Domestic conferenceConfirmation of Proton Beam by Positron Emission Tomography (PET) Apparatus in Patients With Prostate CancerOral presentation
- 第287回日本医学放射線学会関西地方会, Nov. 2007, Japanese, 日本医学放射線学会, 大阪, Domestic conference転移性腫瘍に対する少分割粒子線治療の試みOral presentation
- 第287回日本医学放射線学会関西地方会, Nov. 2007, Japanese, 日本医学放射線学会, 大阪, Domestic conference転移性骨腫瘍に対する粒子線治療の初期経験Oral presentation
- The49thASTRO(AmericanScocietyofTherapeuticradiationOncology), Oct. 2007, English, ASTRO (American Scociety of Therapeutic radiation Oncology), Los Angeles, USA, International conferenceSubacute Central Nervous System Morbidity after Proton Therapy and Carbon Ion Therapy Against Head and Neck Cancers and Skull Base Tumors: Impact of Sequential Evaluation by MR ImagingsOral presentation
- The49thASTRO(AmericanScocietyofTherapeuticradiationOncology), Oct. 2007, English, ASTRO (American Scociety of Therapeutic radiation Oncology), Los Angeles, USA, International conferenceProton Therapy and Carbon Ion Therapy for Patients With Hepatocellular Carcinoma: The Hyogo Ion Beam Medical Center ExperienceOral presentation
- The49thASTRO(AmericanScocietyofTherapeuticradiationOncology), Oct. 2007, English, ASTRO (American Scociety of Therapeutic radiation Oncology), Los Angeles, USA, International conferenceConfirmation of Proton Beam by Positron Emission Tomography (PET) Apparatus in Patients With Prostate CancerOral presentation
- The5thJUCTS(Japan-USCancerTherapySymposium), Sep. 2007, English, JUCTS (Japan-US Cancer Therapy Symposium), 仙台, International conferenceSubacute Radiation Injury following Proton therapy and Carbon Ion Therapy against Head and Neck Cancers and Skull Base TumorsOral presentation
- The14thECCO(EupopeanCancerConference), Sep. 2007, English, ECCO (Eupopean Cancer Conference), Barcelona, Spain, International conferenceSubacute Central Nervus System Morbidity after Proton therapy and Carbon Ion Therapy against Head and Neck Cancers and Skull Base Tumors: Impact of Sequential Evaluation by MR ImagingsOral presentation
- The14thECCO(EupopeanCancerConference), Sep. 2007, English, ECCO (Eupopean Cancer Conference), Barcelona, Spain, International conferenceProton radiotherapy for patients with prostate cancer - in the Hyogo Ion Beam Medical Center (HIBMC) experienceOral presentation
- The5thJUCTS(Japan-USCancerTherapySymposium), Sep. 2007, English, JUCTS (Japan-US Cancer Therapy Symposium), 仙台, International conferenceParticle Therapy Against HCC Clinical Results of 103 casesOral presentation
- The5thJUCTS(Japan-USCancerTherapySymposium), Sep. 2007, English, JUCTS (Japan-US Cancer Therapy Symposium), 仙台, International conferenceIon-beam treatment in Hyogo Ion Beam Medical Center (HIBMC)[Invited]Invited oral presentation
- The14thECCO(EupopeanCancerConference), Sep. 2007, English, ECCO (Eupopean Cancer Conference), Barcelona, Spain, International conferenceConfirmation of proton beam by positron emission tomography apparatus in patients with prostate cancerOral presentation
- The5thJUCTS(Japan-USCancerTherapySymposium), Sep. 2007, English, JUCTS (Japan-US Cancer Therapy Symposium), 仙台, International conferenceAutoactibvation of proton beam confirmed with positron emission tomography in patients with prostate cancer[Invited]Invited oral presentation
- The5thJUCTS(Japan-USCancerTherapySymposium), Sep. 2007, English, JUCTS (Japan-US Cancer Therapy Symposium), 仙台, International conferenceAnalysis of cases with visual impairment caused by particle therapy for head-and neck tumors adjacent to optic nerveOral presentation
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2023 - 31 Mar. 2026難治性局所進行乳がんに対する金属ナノ粒子併用・超高線量率放射線治療法の開発
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2022 - 31 Mar. 2025Space-making radiotherapy using bioabsorbable spacer
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2022 - 31 Mar. 2025Development of radiosensitized nanoparticles for all cancers using simple and innovative surface-modified DDS
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2020 - 31 Mar. 2023獣医療における過酸化チタンナノ粒子を用いた新規・高精度放射線増感療法の開発放射線治療は人医療だけでなく、獣医療でも有効ながん・肉腫の治療手段である。獣医療分野では放射線照射の分割回数を増やせば、全身麻酔回数が増え、疾患動物への負担や侵襲も大きくなるという問題がある。放射線治療は、細胞に対して外因的にエネルギー付与により水の電離を介して活性酸素種(Reactive Oxygen Species, ROS)の発生が細胞傷害性を導くが、がん細胞自体も内因性のROSを持続的に発生し、その消去にためにグルタチオンやカタラーゼなどの還元系酵素の活性が上昇しており、通常のX線照射で発生するROSだけは相殺されてしまうため事が腫瘍の放射線抵抗性の原因と考えられる。この課題を解決するためには、①増感作用のある物質を腫瘍に局所投与し照射を行い、ROSの発生を著名に増加させ放射線増感作用を上昇させる、②強度変調放射線治療IMRT(Intensity Modulated Radiation Therapy)を駆使して照射線量の腫瘍への集中性と総線量の増加、重要臓器への照射線量の低減等が想定されるが、いずれにおいても一回線量を増加させて分割回数を減らしても同等以上の効果が期待できる。申請者らは独自過酸化チタンナノ粒子をがん細胞内に取り込ませX線照射によりROSの著明な発生によって培養細胞やマウス腫瘍モデルにおいて優れた併用効果を確認しているが、今回の申請では種々の肉腫や猫の口腔内扁平上皮癌などの難治性腫瘍に罹患している犬や猫の実際の臨床例における過酸化チタンナノ粒子とIMRT技術を融合させた高精度放射線増感療法の開発とその検証を目的としたが、 本年度の研究成果は、過酸化チタンナノ粒子が免疫放射線療法を著明に増感させ、これまでにない治療効果を得た。
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2020 - 31 Mar. 20233次元積層造形技術を用いた革新的な新規頭頸部放射線治療用固定具の研究開発現行の固定具は、枕やマスクを患者ごとに臨床現場で成型加工しており、その作成には緻密な用手的工程(熱可塑性素材を用手的に患者頭頸部にむらなく密着させ冷却して固める工程)が必要であり、その固定精度は作成担当者(主に診療放射線技師)の技術・熟練度に依存する部分が多く、熟練者であっても1時間程度の時間を要するという非効率を生み出していることが臨床上の問題となっている。元より体調が低下しているがん患者に不動の姿勢を長時間保持させて作成しているのが現状である。しかも、固定具の素材は経時的に改善されて来てはいるが、基本的な作業工程は、この20年以上、ほとんど変化していない。今後のさらなる放射線治療の発展に向け、補助固定具を自動で且つ可及的正確に作成出来る全く新しい発想に基づいた精密な新技術の開発が必要である。 本年度は、①頭頸部データの取得および解析、②頭頸部データに基づいた固定具の設計を予定していた。実際の頭頸部画像のデータから、ソフトウェア処理により3Dポリゴンデータ化する手法を実践できた。また、放射線治療の現場の意見をもとに、固定具の形状の大まかな設計を行うことが出来た。人体模型を使用して、CT画像を撮影・データ取得し、ソフトウェア処理により3Dポリゴンデータを取得し、使用した人体模型に合った固定具の3Dデータ作成を行った。また、CT撮影時の管電圧とCTスライスピッチが与える影響を検証した。具体的には120mV~80mVでX線強度変更を実施して評価した。管電圧は固定具のサイズにほとんど影響を及ぼさないことを確認した。またCT撮影ピッチについても1㎜~5㎜のデータを取得して評価し、撮影ピッチも固定具のサイズにほとんど影響を及ぼさないことを確認した。
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2020 - 31 Mar. 2023金属ナノ粒子を応用した新規・免疫放射線増感療法の開発近年、放射線療法と免疫療法はその併用効果が高いことが報告され、頭頸部がんや肺がん等の多種類の悪性腫瘍で注目されている。現状では腫瘍抗原の一つであるPD-L1発現の有無を免疫染色で確認し治療効果を推測しているが、ヒトがん免疫応答を正確に再現する動物実験モデルはない。また抗PD-L1抗体に不応性の場合もしばしば経験され、特にそのような症例でどのような分子により腫瘍免疫が形成されているかの探索が重要である。我々はこれまで、前臨床試験モデルとして、患者由来のがん組織をマウスで増殖させるPatient-Derived Xenograftモデル(PDXモデル)を作製に成功してきた。このPDX腫瘍モデルは、患者由来の新鮮な腫瘍組織を用いているため、従来のがん細胞株をヌードマウスに移植した動物モデルでとは全く異なる特徴を持ち、より実臨床に近い重要な情報を検討することができる。本研究では、がん症例からの腫瘍組織を採取し、放射線感受性と、ヒトがん免疫応答を再現できる新規動物実験モデルを開発し、免疫応答に関連する新たな腫瘍抗原の探索など新規の放線免疫療法の開発に取り組む。このモデルは、患者個別の放射線感受性、ヒトがん免疫応答の研究、放射線療法との併用療法のトランスレーショナルリサーチに有用である。がんの前臨床試験やトランスレーショナルリサーチに使用する動物実験モデルとして、患者のがん組織を超免疫不全マウス(NOD/SID/IL2rgKOマウス:NSGマウス)に直接移植して継代培養する「患者由来がん異種移植マウスモデル(Patient-Derived Xenograft(PDX) mouse model)」が、広く活用されている。我々の 研究室ではPDXモデルの着手として、乳がんや大腸がん等の様々ながん種によるPDXモデルを精力的に作製してきた
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2020 - 31 Mar. 2023超高線量率スリットビームと金属ナノ粒子を併用した異次元・放射線治療法の開発今年度は新型コロナウィルス感染症の影響もあり、SPring-8での放射光照射実験が実施できなかった。しかしながら、動物実験における腫瘍モデルの作成や、肺転移モデルマウスの作成は問題なく実施できており、未治療での生存期間の検討などを実施した。放射光の照射実験が実施できれば非常に有用な実験データが得られると考えられる。 腫瘍モデルの生着期間や生存期間は癌種によって異なるが、ヒト膵癌由来のMIAPaca2では生着までやく3週間、生存期間は生着後約1か月であり、生着後なるべく早い段階での放射光照射が治療に有用だと考えられる。 肺転移モデルマウスの作成では生着まで約1か月、生存期間は約3か月でありこちらも腫瘍モデルと同様に生着後期間を空けずに照射実験を行う予定である。 SPring-8での放射光照射実験までに、神戸大学医学部にある放射線照射装置においても照射実験を行い、放射光と通常のX線照射装置における線量率の違いによる抗腫瘍効果の検討を追加し、FLASH Radio Therapyの抗腫瘍効果や正常組織反応の解明の一助になるよう検討を加える。 さらに、効率的なマイクロスリットビーム照射を行うためのコリメータの検討も実施しており、次年度はその開発も並行して実施していく予定である。コリメータの開発により、より多様な線量設定が可能となり、より詳細にFLASH Radio Therapyが検討可能になると考えられる。
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2019 - 31 Mar. 2022Space making particle therapy for sarcoma and pediatric tumorThis study is to apply space-making therapy using absorptive spacer, which has been proved useful and safe in particle beam therapy. A Phase 1 clinical trial is planned to verify the consistent safety and efficacy of a series of treatment strategies from absorbable spacer placement in pediatric patients. The absorbable spacer was developed by our group and approved by the Pharmaceutical Affairs (Dec. 11, 2018), preparation of guidelines for proper use (May 2011-June), launch of the absorbable spacer (May 2011.06), and insurance adaptation for the absorbable spacer and its indwelling surgery (December 2019) Class IV medical devices have been clinically applied. The absorbable spacer has published the results of a first-in-human trial in particle beam therapy. Since then, its usefulness has attracted attention worldwide. Feasibility study in pediatic malignancies has been conducted.
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2019 - 31 Mar. 2022Usefulness of exosome-derived PDL1 in radiation therapyThe purpose of this study is to evaluate usefulness of exosome-derived PDL1 as a biomarker in patients with unresectable non-small cell lung cancer treated wit curative chemoradiotherapy. We have obtained blood samples sequentially from patients with stage III non-small cell lung cancer. We have established quantitative methods to measure the exosome-derived PDL1, and have compared pre- and post-treatment blood samples with evaluating occurrence of tumor recurrence or tumor control.Then, we clarified possibilities whether the exosome-derived PDL1 could be an useful biomarker of effectiveness of curative chemoradiotherapy. Moreover, it seems another aspect and cutting edge view point to compare the exosome-derived PDL1 and soluble PDL1 in the serum.
- 学術研究助成基金助成金/基盤研究(C), Apr. 2018 - Mar. 2021Competitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2017 - Mar. 2020Competitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2016 - Mar. 2019Competitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2015 - Mar. 2018, Principal investigatorCompetitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2013 - Mar. 2016Competitive research funding
- 科学研究費一部基金/基盤研究(B)特設, Apr. 2013 - Mar. 2016Competitive research funding
- 学術研究助成基金助成金/若手研究(B), Apr. 2013 - Mar. 2015, Principal investigatorCompetitive research funding
- 科学研究費補助金/基盤研究(C), Apr. 2012 - Mar. 2015Competitive research funding
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Kobe University, 2010 - 2012, Principal investigatorTiOxNP induced ROS generation with X-ray irradiation. Tumor growth inhibitions were significantly greater in mice treated with the combination compared with those treated with X-ray alone. The combination MGDG and X-ray irradiation significantly increased the proportion of apoptotic cells in vitro. In vivo studies, tumor growth inhibitions were significantly greater in mice treated with the combination compared with those treated with X-ray alone.Competitive research funding