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OTAKE Hiromasa
Graduate School of Medicine / Faculty of Medical Sciences
Professor

Researcher basic information

■ Research Areas
  • Life sciences / Medical biochemistry

Research activity information

■ Award
  • Mar. 2009 Kobe University Graduate School of Medicine, Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine., Young Authorship Acheivement Award: JACC Intervention, Local Determinants of Thrombus Formation Following Sirolimus-Eluting Stent Implantation Assessed by Optical Coherence Tomography
    Otake Hiromasa

■ Paper
  • Naoya Kuwahara, Manabu Nagao, Masakazu Shinohara, Kenta Kaneshiro, Takuo Emoto, Takeshi Yoshida, Terunobu Fukuda, Makoto Nishimori, Seimi Satomi-Kobayashi, Hiromasa Otake, Ken-Ichi Hirata, Tatsuro Ishida, Ryuji Toh
    BACKGROUND: ATP citrate lyase (ACLY) is a key enzyme in de novo lipogenesis that generates acetyl-CoA from citrate. Although fatty acids are required for energy production and biomass synthesis in the heart, the regulatory mechanisms of ACLY-mediated de novo lipogenesis in pathological cardiac fibroblasts remain unknown. The aim of this study was to investigate the biological role of ACLY in cardiac remodeling. METHODS: Adeno-associated virus serotype 9-mediated shRNA targeting Acly was intravenously injected into C57BL/6J male mice. The mice were subsequently continuously infused with a mixture of angiotensin II and phenylephrine. Cardiac phenotypes were evaluated via histological staining. Cell proliferation assays, stable isotope tracing with 13C-labeled glucose, and chromatin immunoprecipitation assays were performed using human cardiac fibroblasts. RESULTS: ACLY expression was upregulated in the heart sections of mice treated with angiotensin II/phenylephrine, in particular in fibrotic areas. Masson trichrome staining revealed that Acly gene silencing significantly reduced cardiac fibrosis in these mice. Both siRNA-mediated ACLY knockdown and pharmacological ACLY inhibition suppressed the proliferation and expression of fibrous proteins in cultured human cardiac fibroblasts stimulated with transforming growth factor-β. Mechanistically, ACLY inhibition reduced de novo lipogenesis, limiting the fatty acid supply essential for cellular growth and proliferation. It also decreased H3K9 and H3K27 acetylation, in addition to the presence of acetylated H3K9 and H3K27 at the promoter regions of fibrotic genes. CONCLUSIONS: Our findings demonstrate that ACLY plays an important role in maladaptive cardiac fibrosis. ACLY could be a novel therapeutic target to prevent the development of heart failure.
    Ovid Technologies (Wolters Kluwer Health), Mar. 2025, Hypertension
    Scientific journal

  • Daichi Fujimoto, Eisuke Usui, Rocco Vergallo, Daisuke Kinoshita, Keishi Suzuki, Takayuki Niida, Marco Covani, Iris McNulty, Hang Lee, Hiromasa Otake, Junya Shite, Maros Ferencik, Damini Dey, Tsunekazu Kakuta, Ik-Kyung Jang
    BACKGROUND: Coronary artery calcium score (CACS) is widely used for risk stratification. However, in patients with established coronary artery disease, its clinical implication and relationship with plaque vulnerability are unclear. We sought to correlate the CACS and plaque vulnerability assessed by optical coherence tomography. METHODS: Patients with coronary artery disease who had CACS and optical coherence tomography before percutaneous coronary intervention were included. Patients were divided into 5 groups based on CACS: CACS of 0, 1 to 99, 100 to 399, 400 to 999, and ≥1000. Optical coherence tomography-derived vulnerable features in culprit plaque were compared between the groups. RESULTS: In 460 patients, the prevalence of lipid-rich plaque, macrophage, and cholesterol crystal significantly differed among the 5 groups, being lowest in the patients with a CACS of 0. The prevalence of thin-cap fibroatheroma tended to be lower in those with a CACS of 0. No significant difference in vulnerable features was observed between the 4 groups with CACS >0. In the 2-group comparison between the group with a CACS of 0 and the other 4 groups combined, the prevalence of lipid-rich plaque (60.5% versus 85.9%; P<0.001), macrophage (48.8% versus 74.1%; P<0.001), thin-cap fibroatheroma (16.3% versus 35.0%; P=0.013), and cholesterol crystal (11.6% versus 32.9%; P=0.004) was significantly lower in the patients with CACS of 0. CACS of 0 was independently negatively associated with lipid-rich plaque, macrophage, thin-cap fibroatheroma, and cholesterol crystal after adjustment for patient characteristics. CONCLUSIONS: Patients with a CACS of 0 have a significantly lower prevalence of vulnerable plaque features compared with those with CACS >0 in patients with established coronary artery disease. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04523194.
    Dec. 2024, Circulation. Cardiovascular imaging, e017099, English, International magazine
    Scientific journal

  • Tomoyo Hamana, Makoto Nishimori, Satoki Shibata, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Shunsuke Kakizaki, Satoru Sasaki, Hiroyuki Fujii, Yuto Osumi, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Yuta Fukuishi, Koshi Matsuhama, Hiroshi Tsunamoto, Hiroya Okamoto, Kotaro Higuchi, Tatsuya Kitagawa, Masakazu Shinohara, Koji Kuroda, Masamichi Iwasaki, Amane Kozuki, Junya Shite, Tomofumi Takaya, Ken-Ichi Hirata, Hiromasa Otake
    AIMS: Optical coherence tomography (OCT) can identify high-risk plaques indicative of worsening prognosis in patients with acute coronary syndrome (ACS). However, manual OCT analysis has several limitations. In this study, we aim to construct a deep-learning model capable of automatically predicting ACS prognosis from patient OCT images following percutaneous coronary intervention (PCI). METHODS AND RESULTS: Post-PCI OCT images from 418 patients with ACS were input into a deep-learning model comprising a convolutional neural network (CNN) and transformer. The primary endpoint was target vessel failure (TVF). Model performances were evaluated using Harrell's C-index and compared against conventional models based on human observation of quantitative (minimum lumen area, minimum stent area, average reference lumen area, stent expansion ratio, and lesion length) and qualitative (irregular protrusion, stent thrombus, malapposition, major stent edge dissection, and thin-cap fibroatheroma) factors. GradCAM activation maps were created after extracting attention layers by using the transformer architecture. A total of 60 patients experienced TVF during follow-up (median 961 days). The C-index for predicting TVF was 0.796 in the deep-learning model, which was significantly higher than that of the conventional model comprising only quantitative factors (C-index: 0.640) and comparable to that of the conventional model, including both quantitative and qualitative factors (C-index: 0.789). GradCAM heat maps revealed high activation corresponding to well-known high-risk OCT features. CONCLUSION: The CNN and transformer-based deep-learning model enabled fully automatic prognostic prediction in patients with ACS, with a predictive ability comparable to a conventional survival model using manual human analysis. CLINICAL TRIAL REGISTRATION: The study was registered in the University Hospital Medical Information Network Clinical Trial Registry (UMIN000049237).
    Nov. 2024, European heart journal. Digital health, 5(6) (6), 692 - 701, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Daichi Fujimoto, Daisuke Kinoshita, Keishi Suzuki, Takayuki Niida, Haruhito Yuki, Iris McNulty, Hang Lee, Hiromasa Otake, Junya Shite, Maros Ferencik, Damini Dey, Tsunekazu Kakuta, Ik-Kyung Jang
    BACKGROUND: Coronary artery calcification is an integral part of atherosclerosis. It has been suggested that early coronary artery calcification is associated with active inflammation, and advanced calcification forms as inflammation subsides. Inflammation is also an important factor in plaque vulnerability. However, the relationship between coronary artery calcium burden, vascular inflammation, and plaque vulnerability has not been fully investigated. OBJECTIVES: This study aimed to correlate calcified plaque burden (CPB) at the culprit lesion with vascular inflammation and plaque vulnerability. METHODS: Patients with coronary artery disease who had both computed tomography angiography and optical coherence tomography were included. The authors divided the patients into 4 groups: 1 group without calcification at the culprit lesion; and 3 groups based on the CPB tertiles. CPB was calculated as calcified plaque volume divided by vessel volume in the culprit lesion. The authors compared pericoronary adipose tissue (PCAT) attenuation for vascular inflammation and optical coherence tomography-derived vulnerable features among the 4 groups. RESULTS: Among 578 patients, the highest CPB tertile showed significantly lower PCAT attenuation of culprit vessel compared with the other groups. The prevalence of features of plaque vulnerability (including lipid-rich plaque, macrophage, and microvessel) was also lowest in the highest CPB tertile. In the patients with calcification, higher age, statin use, and lower PCAT attenuation were independently associated with CPB. CONCLUSIONS: Greater calcium burden is associated with a lower level of vascular inflammation and plaque vulnerability. A greater calcium burden may represent advanced stable plaque without significant inflammatory activity. (Massachusetts General Hospital and Tsuchiura Kyodo General Hospital Coronary Imaging Collaboration; NCT04523194).
    Oct. 2024, JACC. Cardiovascular imaging, 17(10) (10), 1214 - 1224, English, International magazine
    Scientific journal

  • Seokhun Yang, Doyeon Hwang, Koshiro Sakai, Takuya Mizukami, Jonathon Leipsic, Marta Belmonte, Jeroen Sonck, Bjarne L Nørgaard, Hiromasa Otake, Brian Ko, Michael Maeng, Jesper Møller Jensen, Dimitri Buytaert, Daniel Munhoz, Daniele Andreini, Hirofumi Ohashi, Toshiro Shinke, Charles A Taylor, Emanuele Barbato, Bernard De Bruyne, Carlos Collet, Bon-Kwon Koo
    BACKGROUND: Vulnerable plaque presents prognostic implications in addition to functional significance. OBJECTIVES: The aim of this study was to identify relevant features of vulnerable plaque in functionally significant lesions. METHODS: In this multicenter, prospective study conducted across 5 countries, including patients who had invasive fractional flow reserve (FFR) ≤0.80, a total of 95 patients with available pullback pressure gradient (PPG) and plaque analysis on coronary computed tomographic angiography and optical coherence tomography were analyzed. Vulnerable plaque was defined as the presence of plaque rupture or thin-cap fibroatheroma on optical coherence tomography. Among the 25 clinical characteristics, invasive angiographic findings, physiological indexes, and coronary computed tomographic angiographic findings, significant predictors of vulnerable plaque were identified. RESULTS: Mean percentage diameter stenosis, FFR, and PPG were 77.8% ± 14.6%, 0.66 ± 0.13, and 0.65 ± 0.13, respectively. Vulnerable plaque was present in 53 lesions (55.8%). PPG and FFR were identified as significant predictors of vulnerable plaque (P < 0.05 for all). PPG >0.65 and FFR ≤0.70 were significantly related to a higher probability of vulnerable plaque after adjustment for each other (OR: 6.75 [95% CI: 2.39-19.1]; P < 0.001] for PPG >0.65; OR: 4.61 [95% CI: 1.66-12.8]; P = 0.003 for FFR ≤0.70). When categorizing lesions according to combined PPG >0.65 and FFR ≤0.70, the prevalence of vulnerable plaque was 20.0%, 57.1%, 66.7%, and 88.2% in the order of PPG ≤0.65 and FFR >0.70, PPG ≤0.65 and FFR ≤0.70, PPG >0.65 and FFR >0.70, and PPG >0.65 and FFR ≤0.70 (P for trend < 0.001), respectively. CONCLUSIONS: Among low-FFR lesions, the presence of vulnerable plaque can be predicted by PPG combined with FFR without additional anatomical or plaque characteristics. (Precise Percutaneous Coronary Intervention Plan [P3] Study; NCT03782688).
    Sep. 2024, JACC. Cardiovascular imaging, English, International magazine
    Scientific journal

  • Hiromasa Otake, Takashi Kubo, Kiyoshi Hibi, Makoto Natsumeda, Masaru Ishida, Toru Kataoka, Tomofumi Takaya, Masamichi Iwasaki, Shinjo Sonoda, Toshiro Shinke, Gaku Nakazawa, Yu Takahashi, Tetsuya Ioji, Takashi Akasaka, Opinion Acs Investigators
    BACKGROUND: The clinical benefits of optical frequency domain imaging (OFDI)-guided percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) remain unclear. AIMS: We sought to compare intravascular ultrasound (IVUS)- and OFDI-guided PCI in patients with ACS. METHODS: OPINION ACS is a multicentre, prospective, randomised, non-inferiority trial that compared OFDI-guided PCI with IVUS-guided PCI using current-generation drug-eluting stents in ACS patients (n=158). The primary endpoint was in-stent minimum lumen area (MLA), assessed using 8-month follow-up OFDI. RESULTS: Patients presented with ST-segment elevation myocardial infarction (55%), non-ST-segment elevation myocardial infarction (29%), or unstable angina pectoris (16%). PCI procedural success was achieved in all patients, with comparably low periprocedural complications rates in both groups. Immediately after PCI, the minimum stent area (p=0.096) tended to be smaller for OFDI versus IVUS guidance. Proximal stent edge dissection (p=0.012) and irregular protrusion (p=0.03) were significantly less frequent in OFDI-guided procedures than in IVUS-guided procedures. Post-PCI coronary flow, assessed using corrected Thrombolysis in Myocardial Infarction frame counts, was significantly better in the OFDI-guided group than in the IVUS-guided group (p<0.001). The least squares mean (95% confidence interval [CI]) in-stent MLA at 8 months was 4.91 (95% CI: 4.53-5.30) mm2 and 4.76 (95% CI: 4.35-5.17) mm2 in the OFDI- and IVUS-guided groups, respectively, demonstrating the non-inferiority of OFDI guidance (pnon-inferiority<0.001). The average neointima area tended to be smaller in the OFDI-guided group. The frequency of major adverse cardiac events was similar. CONCLUSIONS: Among ACS patients, OFDI-guided PCI and IVUS-guided PCI were equally safe and feasible, with comparable in-stent MLA at 8 months. OFDI guidance may be a potential option in ACS patients. This study was registered in the Japan Registry of Clinical Trials (jrct.niph.go.jp: jRCTs052190093).
    Sep. 2024, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 20(17) (17), e1086-e1097, English, International magazine
    Scientific journal

  • Yuto Osumi, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Daichi Fujimoto, Shunsuke Kakizaki, Koichi Nakamura, Tomoyo Hamana, Hiroyuki Fujii, Satoru Sasaki, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Amane Kozuki, Junya Shite, Tomofumi Takaya, Akihiko Ishida, Masamichi Iwasaki, Ken-Ichi Hirata, Hiromasa Otake
    BACKGROUND: Combining morphological and physiological evaluations might improve the risk stratification of patients who undergo percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) culprit lesions. AIMS: We aimed to investigate the clinical utility of morphofunctional evaluation after PCI for identifying ACS patients with increased risk of subsequent clinical events. METHODS: We retrospectively studied 298 consecutive ACS patients who had undergone optical coherence tomography (OCT)-guided PCI. We performed OCT-based morphological analysis and quantitative flow ratio (QFR)-based physiological assessment immediately after PCI. The non-culprit segment (NCS) was defined as the most stenotic untreated segment in the culprit vessel. The primary outcome was target vessel failure (TVF), a composite of cardiac death, target vessel-related myocardial infarction, and ischaemia-driven target vessel revascularisation. RESULTS: During a median follow-up period of 990 days, 42 patients experienced TVF. Cox regression analysis revealed that the presence of thin-cap fibroatheroma (TCFA) in the NCS and a low post-PCI QFR, or the presence of TCFA in the NCS and a high ΔQFR in the NCS (QFRNCS), were independently associated with TVF. The subgroup with TCFA in the NCS and a low post-PCI QFR had a significantly higher incidence of TVF (75%) than the other subgroups, and those with TCFA in the NCS and a high ΔQFRNCS had a significantly higher incidence of TVF (86%) than the other subgroups. The integration of TCFA in NCS, post-PCI QFR, and ΔQFRNCS with traditional risk factors significantly enhanced the identification of subsequent TVF cases. CONCLUSIONS: Combining post-PCI OCT and QFR evaluation may enhance risk stratification for ACS patients after successful PCI, particularly in predicting subsequent TVF.
    Aug. 2024, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 20(15) (15), e927-e936, English, International magazine
    Scientific journal

  • Shintaro Takeda, Takuo Emoto, Tomoya Yamashita, Hiroyuki Yamamoto, Tomofumi Takaya, Takahiro Sawada, Takeshi Yoshida, Masatoshi Inoue, Yuya Suzuki, Tomoyo Hamana, Taishi Inoue, Masayuki Taniguchi, Naoto Sasaki, Hiromasa Otake, Takenao Ohkawa, Tomoyuki Furuyashiki, Hiroya Kawai, Ken-Ichi Hirata
    BACKGROUND: Acute coronary syndrome (ACS) involves plaque-related thrombosis, causing primary ischemic cardiomyopathy or lethal arrhythmia. We previously demonstrated a unique immune landscape of myeloid cells in the culprit plaques causing ACS by using single-cell RNA sequencing. Here, we aimed to characterize T cells in a single-cell level, assess clonal expansion of T cells, and find a therapeutic target to prevent ACS. METHODS: We obtained the culprit lesion plaques from 4 patients with chronic coronary syndrome (chronic coronary syndrome plaques) and the culprit lesion plaques from 3 patients with ACS (ACS plaques) who were candidates for percutaneous coronary intervention with directional coronary atherectomy. Live CD45+ immune cells were sorted from each pooled plaque samples and applied to the 10× platform for single-cell RNA sequencing analysis. We also extracted RNA from other 3 ACS plaque samples and conducted unbiased TCR (T-cell receptor) repertoire analysis. RESULTS: CD4+ T cells were divided into 5 distinct clusters: effector, naive, cytotoxic, CCR7+ (C-C chemokine receptor type 7) central memory, and FOXP3 (forkhead box P3)+ regulatory CD4+ T cells. The proportion of central memory CD4+ T cells was higher in the ACS plaques. Correspondingly, dendritic cells also tended to express more HLAs (human leukocyte antigens) and costimulatory molecules in the ACS plaques. The velocity analysis suggested the differentiation flow from central memory CD4+ T cells into effector CD4+ T cells and that from naive CD4+ T cells into central memory CD4+ T cells in the ACS plaques, which were not observed in the chronic coronary syndrome plaques. The bulk repertoire analysis revealed clonal expansion of TCRs in each patient with ACS and suggested that several peptides in the ACS plaques work as antigens and induced clonal expansion of CD4+ T cells. CONCLUSIONS: For the first time, we revealed single cell-level characteristics of CD4+ T cells in patients with ACS. CD4+ T cells could be therapeutic targets of ACS. REGISTRATION: URL: https://upload.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000046521; Unique identifier: UMIN000040747.
    May 2024, Arteriosclerosis, thrombosis, and vascular biology, 44(5) (5), 1135 - 1143, English, International magazine
    [Refereed]
    Scientific journal

  • Brian Ko, Hirofumi Ohashi, Takuya Mizukami, Koshiro Sakai, Jeroen Sonck, Bjarne Linde Nørgaard, Michael Maeng, Jesper Møller Jensen, Abdul Ihdayhid, Atomu Tajima, Hirohiko Ando, Tetsuya Amano, Bernard De Bruyne, Bon-Kwon Koo, Hiromasa Otake, Carlos Collet
    Elsevier BV, May 2024, Journal of Cardiovascular Computed Tomography
    Scientific journal

  • Frederic Bouisset, Hirofumi Ohashi, Ruiko Seiki, Takuya Mizukami, Bjarne Linde Norgaard, Nicolaj Brejnholt Stottrup, Carlo Zivelonghi, Brian Ko, Hiromasa Otake, Jeroen Sonck, Bon-Kwon Koo, Tetsuya Amano, Adriaan Wilgenhof, Pierfrancesco Agostoni, Carlos Collet
    May 2024, Journal of cardiovascular computed tomography, English, International magazine

  • Satoru Sasaki, Hiroyuki Kawamori, Takayoshi Toba, Ryo Takeshige, Yusuke Fukuyama, Takashi Hiromasa, Hiroyuki Fujii, Tomoyo Hamana, Yuto Osumi, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Toshiro Shinke, Ken-Ichi Hirata, Hiromasa Otake
    BACKGROUND: Fractional flow reserve-computed tomography (FFRCT) has not been validated in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) for coronary artery disease due to theoretical difficulties in using nitroglycerin for such patients.Methods and Results: In this single-center study, we prospectively enrolled 21 patients (34 vessels) and performed pre-TAVR FFRCTwithout nitroglycerin, pre-TAVR invasive instantaneous wave-free ratio (iFR) measurements, and post-TAVR FFR measurements using a pressure wire. The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of pre-TAVR FFRCT≤0.80 to predict post-TAVR invasive FFR ≤0.80 were 82%, 83%, 82%, 71%, and 90%, respectively. A receiver operating characteristic analysis demonstrated an optimal cutoff of 0.78 for pre-TAVR FFRCTto indicate post-TAVR FFR ≤0.80, with an area under the curve (AUC) of 0.84, and the counterpart cutoff of pre-TAVR iFR was 0.89 with an AUC of 0.86. CONCLUSIONS: FFRCTwithout nitroglycerin could be a useful non-invasive imaging modality for assessing the severity of coronary artery lesions in patients with severe AS.
    Mar. 2024, Circulation journal : official journal of the Japanese Circulation Society, 88(4) (4), 501 - 509, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Fukuishi Yuta, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Satoru Sasaki, Tomoyo Hamana, Hiroyuki Fujii, Yuto Osumi, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Ken-Ichi Hirata, Hiromasa Otake
    BACKGROUND: Murray law-based quantitative flow ratio (μQFR) is a novel computational method that enables accurate estimation of fractional flow reserve (FFR) using a single angiographic projection. However, its diagnostic value in patients with severe aortic stenosis (AS) remains unclear. METHOD: We included 25 consecutive patients who underwent transcatheter aortic valve replacement (TAVR) for severe AS with intermediate or greater (30-90%) coronary artery disease (CAD). Pre- and post-TAVR μQFR, QFR, instantaneous flow reserve (iFR), and post-TAVR invasive FFR values were measured. We evaluated the diagnostic performance of pre-TAVR μQFR, QFR, and iFR using post-TAVR FFR ≤ 0.80 as a reference standard of ischemia. RESULT: Pre-TAVR μQFR was significantly correlated with post-TAVR FFR (r = 0.73, p < 0.0001). The area under the curve of pre-TAVR μQFR on post-TAVR FFR ≤ 0.8 was 0.91 (95% confidence interval [CI] 0.77-0.98), comparable to that of pre-TAVR iFR (0.86 [95% CI 0.71-0.98], p = 0.97). The accuracy, sensitivity, specificity, and positive and negative predictive values of pre-TAVR μQFR on post-TAVR FFR ≤ 0.8 were 84.2% (95% CI 68.7-93.4), 61.6% (95% CI 31.6-86.1), 96.0% (95% CI 79.6-99.9), 88.9% (95% CI 52.9-98.3), and 82.8% (95% CI 70.6-90.6), respectively. For pre-TAVR iFR, these values were 76.5% (95% CI 58.8-89.3), 90.9% (95% CI 58.7-99.8), 69.6% (95% CI 47.1-86.8), 58.8% (95% CI 42.8-73.1), and 94.1% (95% CI 70.8-99.1), respectively. CONCLUSION: μQFR could be useful for the physiological evaluation of patients with severe AS with concomitant CAD.
    Mar. 2024, Heart and vessels, English, Domestic magazine
    Scientific journal

  • Alessandro Candreva, Diego Gallo, Daniel Munhoz, Maurizio Lodi Rizzini, Takuya Mizukami, Ruiko Seki, Koshiro Sakai, Jeroen Sonck, Valentina Mazzi, Brian Ko, Bjarne Linde Nørgaard, Jesper Møller Jensen, Michael Maeng, Hiromasa Otake, Bon-Kwon Koo, Toshiro Shinke, Jean-Paul Aben, Daniele Andreini, Emanuele Gallinoro, Barbara E Stähli, Christian Templin, Claudio Chiastra, Bernard De Bruyne, Umberto Morbiducci, Carlos Collet
    BACKGROUND AND AIMS: Coronary hemodynamics impact coronary plaque progression and destabilization. The aim of the present study was to establish the association between focal vs. diffuse intracoronary pressure gradients and wall shear stress (WSS) patterns with atherosclerotic plaque composition. METHODS: Prospective, international, single-arm study of patients with chronic coronary syndromes and hemodynamic significant lesions (fractional flow reserve [FFR] ≤ 0.80). Motorized FFR pullback pressure gradient (PPG), optical coherence tomography (OCT), and time-average WSS (TAWSS) and topological shear variation index (TSVI) derived from three-dimensional angiography were obtained. RESULTS: One hundred five vessels (median FFR 0.70 [Interquartile range (IQR) 0.56-0.77]) had combined PPG and WSS analyses. TSVI was correlated with PPG (r = 0.47, [95% Confidence Interval (95% CI) 0.30-0.65], p < 0.001). Vessels with a focal CAD (PPG above the median value of 0.67) had significantly higher TAWSS (14.8 [IQR 8.6-24.3] vs. 7.03 [4.8-11.7] Pa, p < 0.001) and TSVI (163.9 [117.6-249.2] vs. 76.8 [23.1-140.9] m-1, p < 0.001). In the 51 vessels with baseline OCT, TSVI was associated with plaque rupture (OR 1.01 [1.00-1.02], p = 0.024), PPG with the extension of lipids (OR 7.78 [6.19-9.77], p = 0.003), with the presence of thin-cap fibroatheroma (OR 2.85 [1.11-7.83], p = 0.024) and plaque rupture (OR 4.94 [1.82 to 13.47], p = 0.002). CONCLUSIONS: Focal and diffuse coronary artery disease, defined using coronary physiology, are associated with differential WSS profiles. Pullback pressure gradients and WSS profiles are associated with atherosclerotic plaque phenotypes. Focal disease (as identified by high PPG) and high TSVI are associated with high-risk plaque features. CLINICAL TRIAL REGISTRATION: https://clinicaltrials,gov/ct2/show/NCT03782688.
    Mar. 2024, International journal of cardiology, 399, 131668 - 131668, English, International magazine
    Scientific journal

  • Prognostic Significance of Nodular Calcification Derived from Non-contrast Coronary Computed Tomography in Percutaneous Coronary Intervention(タイトル和訳中)
    岩根 成豪, 鳥羽 敬義, 川森 裕之, 廣正 聖, 佐々木 諭, 藤井 寛之, 濱名 智世, 大隅 祐人, 山本 哲也, 綱本 浩志, 浪花 祥太, 坂本 優樹, 松濱 考志, 福石 悠太, 高橋 悠, 伊澤 有, 山本 裕之, 高谷 具史, 平田 健一, 大竹 寛雅
    (一社)日本循環器学会, Mar. 2024, 日本循環器学会学術集会抄録集, 88回, OJ15 - 4, English

  • Hirofumi Ohashi, Takuya Mizukami, Jeroen Sonck, Frederic Boussiet, Brian Ko, Bjarne L Nørgaard, Michael Mæng, Jesper Møller Jensen, Koshiro Sakai, Hirohiko Ando, Tetsuya Amano, Nicolas Amabile, Ziad Ali, Bernard De Bruyne, Bon-Kwon Koo, Hiromasa Otake, Carlos Collet
    BACKGROUND: Following percutaneous coronary intervention (PCI), optical coherence tomography provides prognosis information. The pullback pressure gradient is a novel index that discriminates focal from diffuse coronary artery disease based on fractional flow reserve pullbacks. We sought to investigate the association between coronary artery disease patterns, defined by coronary physiology, and optical coherence tomography after stent implantation in stable patients undergoing PCI. METHODS AND RESULTS: This multicenter, prospective, single-arm study was conducted in 5 countries (NCT03782688). Subjects underwent motorized fractional flow reserve pullbacks evaluation followed by optical coherence tomography-guided PCI. Post-PCI optical coherence tomography minimum stent area, stent expansion, and the presence of suboptimal findings such as incomplete stent apposition, stent edge dissection, and irregular tissue protrusion were compared between patients with focal versus diffuse disease. Overall, 102 patients (105 vessels) were included. Fractional flow reserve before PCI was 0.65±0.14, pullback pressure gradient was 0.66±0.14, and post-PCI fractional flow reserve was 0.88±0.06. The mean minimum stent area was 5.69±1.99 mm2 and was significantly larger in vessels with focal disease (6.18±2.12 mm2 versus 5.19±1.72 mm2, P=0.01). After PCI, incomplete stent apposition, stent edge dissection, and irregular tissue protrusion were observed in 27.6%, 10.5%, and 51.4% of the cases, respectively. Vessels with focal disease at baseline had a lower prevalence of incomplete stent apposition (11.3% versus 44.2%, P=0.002) and more irregular tissue protrusion (69.8% versus 32.7%, P<0.001). CONCLUSIONS: Baseline coronary pathophysiological patterns are associated with suboptimal imaging findings after PCI. Patients with focal disease had larger minimum stent area and a higher incidence of tissue protrusion, whereas stent malapposition was more frequent in patients with diffuse disease.
    Feb. 2024, Journal of the American Heart Association, e032605, English, International magazine
    Scientific journal

  • Tetsuya Yamamoto, Hiroyuki Kawamori, Takayoshi Toba, Satoru Sasaki, Hiroyuki Fujii, Tomoyo Hamana, Yuto Osumi, Seigo Iwane, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Ken-Ichi Hirata, Hiromasa Otake
    BACKGROUND: Perivascular inflammation contributes to the development of atherosclerosis and microcirculatory dysfunction. Pericoronary adipose tissue (PCAT) attenuation, measured by coronary computed tomography angiography, is a potential indicator of coronary inflammation. However, the relationship between PCAT attenuation, microcirculatory dysfunction, and periprocedural myocardial injury (PMI) remains unclear. METHODS AND RESULTS: Patients with chronic coronary syndrome who underwent coronary computed tomography angiography before percutaneous coronary intervention were retrospectively identified. PCAT attenuation and adverse plaque characteristics were assessed using coronary computed tomography angiography. The extent of microcirculatory dysfunction was evaluated using the angio-based index of microcirculatory resistance before and after percutaneous coronary intervention. Overall, 125 consecutive patients were included, with 50 experiencing PMI (PMI group) and 75 without PMI (non-PMI group). Multivariable analysis showed that older age, higher angio-based index of microcirculatory resistance, presence of adverse plaque characteristics, and higher lesion-based PCAT attenuation were independently associated with PMI occurrence (odds ratio [OR], 1.07 [95% CI, 1.01-1.13]; P=0.02; OR, 1.06 [95% CI, 1.00-1.12]; P=0.04; OR, 6.62 [95% CI, 2.13-20.6]; P=0.001; and OR, 2.89 [95% CI, 1.63-5.11]; P<0.001, respectively). High PCAT attenuation was correlated with microcirculatory dysfunction before and after percutaneous coronary intervention and its exacerbation during percutaneous coronary intervention. Adding lesion-based PCAT attenuation to the presence of adverse plaque characteristics improved the discriminatory and reclassification ability in predicting PMI. CONCLUSIONS: Adding PCAT attenuation at the culprit lesion level to coronary computed tomography angiography-derived adverse plaque characteristics may provide incremental benefit in identifying patients at risk of PMI. Our results highlight the importance of microcirculatory dysfunction in PMI development, particularly in the presence of lesions with high PCAT attenuation. REGISTRATION: URL: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000057722; Unique identifier: UMIN000050662.
    Feb. 2024, Journal of the American Heart Association, 13(3) (3), e031209, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Ko Yamamoto, Hiroki Shiomi, Takeshi Morimoto, Akiyoshi Miyazawa, Hiroki Watanabe, Sunao Nakamura, Satoru Suwa, Takenori Domei, Koh Ono, Hiroki Sakamoto, Masataka Shigetoshi, Ryoji Taniguchi, Hideki Okayama, Takafumi Yokomatsu, Masahiro Muto, Ren Kawaguchi, Koichi Kishi, Mitsuyoshi Hadase, Tsutomu Fujita, Yasunori Nishida, Masami Nishino, Hiromasa Otake, Masahiro Natsuaki, Hirotoshi Watanabe, Nobuhiro Suematsu, Kengo Tanabe, Mitsuru Abe, Kiyoshi Hibi, Kazushige Kadota, Kenji Ando, Takeshi Kimura
    Japanese Circulation Society, Oct. 2023, Circulation Journal, 87(11) (11), 1661 - 1671
    Scientific journal

  • Daniele Andreini, Marta Belmonte, Martin Penicka, Lieven Van Hoe, Niya Mileva, Pasquale Paolisso, Sakura Nagumo, Bjarne L Nørgaard, Brian Ko, Hiromasa Otake, Bon-Kwon Koo, Jesper Møller Jensen, Takuya Mizukami, Daniel Munhoz, Adam Updegrove, Charles Taylor, Jonathon Leipsic, Jeroen Sonck, Bernard De Bruyne, Carlos Collet
    OBJECTIVE: To assess the accuracy of a virtual stenting tool based on coronary CT angiography (CCTA) and fractional flow reserve (FFR) derived from CCTA (FFRCT Planner) across different levels of image quality. MATERIALS AND METHODS: Prospective, multicenter, single-arm study of patients with chronic coronary syndromes and lesions with FFR ≤ 0.80. All patients underwent CCTA performed with recent-generation scanners. CCTA image quality was adjudicated using the four-point Likert scale at a per-vessel level by an independent committee blinded to the FFRCT Planner. Patient- and technical-related factors that could affect the FFRCT Planner accuracy were evaluated. The FFRCT Planner was applied mirroring percutaneous coronary intervention (PCI) to determine the agreement with invasively measured post-PCI FFR. RESULTS: Overall, 120 patients (123 vessels) were included. Invasive post-PCI FFR was 0.88 ± 0.06 and Planner FFRCT was 0.86 ± 0.06 (mean difference 0.02 FFR units, the lower limit of agreement (LLA) - 0.12, upper limit of agreement (ULA) 0.15). CCTA image quality was assessed as excellent (Likert score 4) in 48.3%, good (Likert score 3) in 45%, and sufficient (Likert score 2) in 6.7% of patients. The FFRCT Planner was accurate across different levels of image quality with a mean difference between FFRCT Planner and invasive post-PCI FFR of 0.02 ± 0.07 in Likert score 4, 0.02 ± 0.07 in Likert score 3 and 0.03 ± 0.08 in Likert score 2, p = 0.695. Nitrate dose ≥ 0.8mg was the only independent factor associated with the accuracy of the FFRCT Planner (95%CI - 0.06 to - 0.001, p = 0.040). CONCLUSION: The FFRCT Planner was accurate in predicting post-PCI FFR independent of CCTA image quality. CLINICAL RELEVANCE STATEMENT: Being accurate in predicting post-PCI FFR across a wide spectrum of CT image quality, the FFRCT Planner could potentially enhance and guide the invasive treatment. Adequate vasodilation during CT acquisition is relevant to improve the accuracy of the FFRCT Planner. KEY POINTS: • The fractional flow reserve derived from coronary CT angiography (FFRCT) Planner is a novel tool able to accurately predict fractional flow reserve after percutaneous coronary intervention. • The accuracy of the FFRCT Planner was confirmed across a wide spectrum of CT image quality. Nitrates dose at CT acquisition was the only independent predictor of its accuracy. • The FFRCT Planner could potentially enhance and guide the invasive treatment.
    Oct. 2023, European radiology, English, International magazine
    Scientific journal

  • Masahiro Yamawaki, Yoshinobu Murasato, Yusuke Watanabe, Yoshihisa Kinoshita, Munenori Okubo, Kazuhiko Yumoto, Naoki Masuda, Hiromasa Otake, Jiro Aoki, Gaku Nakazawa, Yohei Numasawa, Tatsuya Ito, Junya Shite, Takayuki Okamura, Kensuke Takagi, Kayoko Kozuma, Thierry Lefèvre, Bernard Chevalier, Yves Louvard, Nobuaki Suzuki, Ken Kozuma
    BACKGROUND: The impact of coronary bifurcation angle (BA) on incomplete stent apposition (ISA) after crossover stenting followed by side branch (SB) intervention has not been established. METHODS: A total of 100 crossover stentings randomly treated with proximal optimization technique followed by short balloon dilation in the SB (POT-SBD group, 48 patients) and final kissing balloon technique (KBT group, 52 patients) were analyzed in the PROPOT trial. Major ISA with maximum distance > 400 μm and its location was determined using optical coherence tomography before SB intervention and at the final procedure. The BA was defined as the angle between the distal main vessel and SB. Optimal POT was determined when the difference in stent volume index between the proximal and distal bifurcation was greater than the median value (0.86 mm3/mm) before SB intervention. RESULT: Major ISA was more frequently observed in the POT-SBD than in the KBT group (35% versus 17%, p < 0.05). In the POT-SBD group, worsening ISA after SBD was prominent at the distal bifurcation. The BA was an independent predictor of major ISA (odds ratio 1.04, 95% confidence interval 1.00-1.07, p < 0.05) with a cut-off value of 59.5° (p < 0.05). However, the cases treated with optimal POT in the short BA (<60°) indicated the lowest incidence of major ISA. In the KBT group, BA had no significant impact. CONCLUSION: A wide BA has a potential risk for the occurrence of major ISA after POT followed by SBD in coronary bifurcation stenting.
    Oct. 2023, International journal of cardiology. Heart & vasculature, 48, 101265 - 101265, English, International magazine
    Scientific journal

  • Tetsuya Yamamoto, Hiroyuki Kawamori, Takayoshi Toba, Shunsuke Kakizaki, Koichi Nakamura, Daichi Fujimoto, Satoru Sasaki, Hiroyuki Fujii, Tomoyo Hamana, Yuto Osumi, Seigo Iwane, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Amane Kozuki, Junya Shite, Masamichi Iwasaki, Akihiko Ishida, Ken-Ichi Hirata, Hiromasa Otake
    BACKGROUND: Drug-coated balloon (DCB) became a potential treatment option for patients with acute coronary syndrome (ACS); however, factors associated with target lesion failure (TLF) remain uncertain. METHODS: This retrospective, multicentre, observational study included consecutive ACS patients who underwent optical coherence tomography (OCT)-guided DCB treatment. Patients were divided into two groups according to the occurrence of TLF, a composite of cardiac death, target vessel-related myocardial infarction, and ischemia-driven target lesion revascularisation. RESULTS: We enrolled 127 patients in this study. During the median follow-up period of 562 (IQR: 342-1164) days, 24 patients (18.9%) experienced TLF, and 103 patients (81.1%) did not. The cumulative 3-year incidence of TLF was 22.0%. The cumulative 3-year incidence of TLF was the lowest in patients with plaque erosion (PE) (7.5%), followed by those with rupture (PR) (26.1%) and calcified nodule (CN) (43.5%). Multivariable Cox regression analysis revealed that plaque morphology was independently associated with TLF on pre-PCI (percutaneous coronary intervention) OCT, and residual thrombus burden (TB) was positively associated with TLF on post-PCI OCT. Further stratification by post-PCI TB revealed a comparable incidence of TLF in patients with PR (4.2%) to that of PE if the culprit lesion had a smaller post-PCI TB than the cut-off value (8.4%). TLF incidence was high in patients with CN, regardless of TB size on post-PCI OCT. CONCLUSIONS: Plaque morphology was strongly associated with TLF for ACS patients after DCB treatment. Residual TB post-PCI might be a key determinant for TLF, especially in patients with PR.
    Sep. 2023, International journal of cardiology, 387, 131149 - 131149, English, International magazine
    Scientific journal

  • Taishi Yonetsu, Kohei Wakabayashi, Takuya Mizukami, Myong Hwa Yamamoto, Sakiko Yasuhara, Seita Kondo, Yosuke Oishi, Toshitaka Okabe, Tomoyo Sugiyama, Makoto Araki, Masamichi Takano, Nobuaki Kobayashi, Shigeki Kimura, Yosuke Yamakami, Satoru Suwa, Sunao Nakamura, Satoru Mitomo, Tsunekazu Kakuta, Eisuke Usui, Takumi Higuma, Junya Ako, Yoshiyasu Minami, Masamichi Iwasaki, Junya Shite, Amane Kozuki, Shigeru Saito, Koki Shishido, Hiroyuki Okura, Genki Naruse, Shiro Uemura, Teruyoshi Kume, Mamoru Nanasato, Tomotaka Dohi, Takashi Ashikaga, Hiromasa Otake, Hiroyoshi Mori, Teruo Sekimoto, Yoichiro Sugizaki, Toshiro Shinke
    Even after successful revascularization with primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI), subsequent adverse events still occur. Previous studies have suggested potential benefits of intravascular imaging, including optical coherence tomography (OCT). However, the feasibility of OCT-guided primary PCI has not been systematically examined in these patients. The ATLAS-OCT (ST-elevation Acute myocardial infarcTion and cLinicAl outcomeS treated by Optical Coherence Tomography-guided percutaneous coronary intervention) trial was designed to investigate the feasibility of OCT guidance during primary PCI for STEMI in experienced centers with expertise on OCT-guided PCI as a prospective, multicenter registry of consecutive patients with STEMI who underwent a primary PCI. The sites' inclusion criteria are as follows: (1) acute care hospitals providing 24/7 emergency care for STEMI, and (2) institutions where OCT-guided PCI is the first choice for primary PCI in STEMI. All patients with STEMI who underwent primary PCI at participating sites will be consecutively enrolled, irrespective of OCT use during PCI. The primary end point will be the rate of successful OCT imaging during the primary PCI. As an ancillary imaging modality to angiography, OCT provides morphologic information during PCI for the assessment of plaque phenotypes, vessel sizing, and PCI optimization. Major adverse cardiac events, defined as a composite of all-cause death, myocardial infarction, and target vessel revascularization at 1 year, will also be recorded. The ATLAS-OCT study will clarify the feasibility of OCT-guided primary PCI for patients with STEMI and further identify a suitable patient group for OCT-guided primary PCI.
    Aug. 2023, The American journal of cardiology, 203, 466 - 472, English, International magazine
    Scientific journal

  • 経カテーテル大動脈弁置換術施行患者における冠動脈造影検査に基づく定量的冠血流比の有効性
    福石 悠太, 川森 裕之, 鳥羽 敬義, 佐々木 諭, 藤井 寛之, 濱名 智世, 大隅 祐人, 岩根 成豪, 山本 哲也, 浪花 祥太, 坂本 優樹, 松濱 考志, 平田 健一, 大竹 寛雅
    (一社)日本心血管インターベンション治療学会, Aug. 2023, 日本心血管インターベンション治療学会抄録集, 31回, MO26 - 1, English

  • OFDIを用いたロータブレータの切削効果予測の検討
    濱名 智世, 大竹 寛雅, 川森 裕之, 鳥羽 敬義, 西森 誠, 佐々木 諭, 大隅 祐人, 岩根 成豪, 山本 哲也, 浪花 祥太, 坂本 優樹, 福石 悠太, 松濱 孝志, 平田 健一
    (一社)日本心血管インターベンション治療学会, Aug. 2023, 日本心血管インターベンション治療学会抄録集, 31回, MP22 - 8, English

  • Ko Yamamoto, Hiroki Shiomi, Takeshi Morimoto, Akiyoshi Miyazawa, Hiroki Watanabe, Sunao Nakamura, Satoru Suwa, Takenori Domei, Koh Ono, Hiroki Sakamoto, Masataka Shigetoshi, Ryoji Taniguchi, Hideki Okayama, Toshiaki Toyota, Takafumi Yokomatsu, Masahiro Muto, Ren Kawaguchi, Koichi Kishi, Mitsuyoshi Hadase, Tsutomu Fujita, Yasunori Nishida, Masami Nishino, Hiromasa Otake, Masahiro Natsuaki, Hirotoshi Watanabe, Nobuhiro Suematsu, Kengo Tanabe, Mitsuru Abe, Kiyoshi Hibi, Kazushige Kadota, Kenji Ando, Takeshi Kimura
    Elsevier BV, Aug. 2023, JACC: Asia, 3(4) (4), 649 - 661
    Scientific journal

  • Tomoyo Hamana, Hiroyuki Kawamori, Takayoshi Toba, Makoto Nishimori, Kosuke Tanimura, Shunsuke Kakizaki, Koichi Nakamura, Daichi Fujimoto, Satoru Sasaki, Yuto Osumi, Masayoshi Fujii, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Yuta Fukuishi, Koshi Matsuhama, Ken-Ichi Hirata, Hiromasa Otake
    This study determined the predictive accuracy of optical frequency domain imaging (OFDI) on debulking effects of rotational atherectomy (RA) and compared the predictive accuracy of OFDI catheter-based with Rota wire-based prediction methods. This prospective, single-center, observational study included 55 consecutive patients who underwent OFDI-guided RA. On pre-RA OFDI images, a circle, identical to the Rota burr was drawn at the center of the OFDI catheter (OFDI catheter-based prediction method) or wire (wire-based prediction method). The area overlapping the vessel wall was defined as the predicted ablation area (P-area). The actual ablated area (A-area) was measured by superimposing the OFDI images before and after RA. The overlapping P-area and A-area were defined as overlapped ablation area (O-area), and the predictive accuracy was evaluated by %Correct area (O-area/P-area) and %Error area (A-area  - O-area/A-area). The median %Correct and %Error areas were 47.8% and 41.6%, respectively. Irrelevant ablation (low %Correct-/high % Error areas) and over ablation (high %Correct-/high % Error areas) were related to deep vessel injury and intimal flap outside the P-area. The predictive accuracy was better in the OFDI catheter-based prediction method than the wire-based prediction method in the cross sections where the OFDI catheter and wire came in contact. However, it was better in the latter than the former where the OFDI catheter and wire were not in contact. OFDI-based simulation of the RA effect is feasible though accuracy may be affected by the OFDI catheter and wire position. OFDI-based simulation of RA effect might reduce peri-procedural complications during RA.
    Jul. 2023, Cardiovascular intervention and therapeutics, 38(3) (3), 316 - 326, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Koshiro Sakai, Takuya Mizukami, Jonathon Leipsic, Marta Belmonte, Jeroen Sonck, Bjarne L. Nørgaard, Hiromasa Otake, Brian Ko, Bon-kwon Koo, Michael Maeng, Jesper Møller Jensen, Dimitri Buytaert, Daniel Munhoz, Daniele Andreini, Hirofumi Ohashi, Toshiro Shinke, Charles A. Taylor, Emanuele Barbato, Nils P. Johnson, Bernard De Bruyne, Carlos Collet
    Elsevier BV, Jul. 2023, JACC: Cardiovascular Imaging
    Scientific journal

  • Niya Mileva, Hirofumi Ohashi, Pasquale Paolisso, Jonathon Leipsic, Takuya Mizukami, Jeroen Sonck, Bjarne L Norgaard, Hiromasa Otake, Brian Ko, Michael Maeng, Daniel Munhoz, Sakura Nagumo, Marta Belmonte, Dobrin Vassilev, Daniele Andreini, Emanuele Barbato, Bon-Kwon Koo, Bernard De Bruyne, Carlos Collet
    BACKGROUND: Fractional flow reserve (FFR) measured after percutaneous coronary intervention (PCI) carries prognostic information. Yet, myocardial mass subtended by a stenosis influences FFR. We hypothesized that a smaller coronary lumen volume and a large myocardial mass might be associated with lower post-PCI FFR. AIM: We sought to assess the relationship between vessel volume, myocardial mass, and post-PCI FFR. METHODS: This was a subanalysis with an international prospective study of patients with significant lesions (FFR ≤ 0.80) undergoing PCI. Territory-specific myocardial mass was calculated from coronary computed tomography angiography (CCTA) using the Voronoi's algorithm. Vessel volume was extracted from quantitative CCTA analysis. Resting full-cycle ratio (RFR) and FFR were measured before and after PCI. We assessed the association between coronary lumen volume (V) and its related myocardial mass (M), and the percent of total myocardial mass (%M) with post-PCI FFR. RESULTS: We studied 120 patients (123 vessels: 94 left anterior descending arteries, 13 left Circumflex arteries, 16 right coronary arteries). Mean vessel-specific mass was 61 ± 23.1 g (%M 39.6 ± 11.7%). The mean post-PCI FFR was 0.88 ± 0.06 FFR units. Post-PCI FFR values were lower in vessels subtending higher mass (0.87 ± 0.05 vs. 0.89 ± 0.07, p = 0.047), and with lower V/M ratio (0.87 ± 0.06 vs. 0.89 ± 0.07, p = 0.02). V/M ratio correlated significantly with post-PCI RFR and FFR (RFR r = 0.37, 95% CI: 0.21-0.52, p < 0.001 and FFR r = 0.41, 95% CI: 0.26-0.55, p < 0.001). CONCLUSION: Post-PCI RFR and FFR are associated with the subtended myocardial mass and the coronary volume to mass ratio. Vessels with higher mass and lower V/M ratio have lower post-PCI RFR and FFR.
    Jun. 2023, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 101(7) (7), 1182 - 1192, English, International magazine
    Scientific journal

  • Daichi Fujimoto, Masakazu Shinohara, Hiroyuki Kawamori, Takayoshi Toba, Shunsuke Kakizaki, Koichi Nakamura, Satoru Sasaki, Tomoyo Hamana, Hiroyuki Fujii, Yuto Osumi, Naomi Hayasaka, Shigenobu Kishino, Jun Ogawa, Ken-ichi Hirata, Hiromasa Otake
    Elsevier BV, Jun. 2023, Atherosclerosis, 375, 1 - 8
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takayoshi Toba, Tomoyo Hamana, Hiroyuki Kawamori, Sho Torii, Gaku Nakazawa, Hiromasa Otake
    May 2023, Cardiovascular intervention and therapeutics, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Tomoyo Hamana, Hiromasa Otake, Shoichi Kuramitsu, Tomohiro Shinozaki, Masanobu Ohya, Kazunori Horie, Hiroyoshi Kawamoto, Futoshi Yamanaka, Masahiro Natsuaki, Hiroki Shiomi, Gaku Nakazawa, Kenji Ando, Kazushige Kadota, Shigeru Saito, Takeshi Kimura
    BACKGROUND: Cancer-associated thrombosis is a frequent complication of cancer; however, little evidence is available regarding the association between cancer history and coronary artery stent thrombosis (ST). We aimed to investigate the relationship between cancer history and second-generation drug-eluting stent thrombosis (G2-ST). METHODS: From the REAL-ST (Retrospective Multicenter Registry of ST After First- and Second-Generation Drug-Eluting Stent Implantation) registry, this study evaluated 1265 patients (G2- ST cases, n = 253; controls, n = 1012) with cancer-related information available. RESULTS: The prevalence of patients with cancer history was higher (12.3% vs. 8.5%, p = 0.065), and that of currently diagnosed and currently treated cancer was significantly higher in ST cases than controls (3.6% vs. 1.4%, p = 0.021; 3.2% vs. 1.3%, p = 0.037, respectively). Multivariable logistic regression analysis revealed that cancer history was associated with late ST (odds ratio [OR]: 2.80, 95% confidence intervals [CI]: 0.92-8.55, p = 0.071) and very late ST (OR: 2.40, 95% CI: 1.02-5.65, p = 0.046), but not with early ST (OR: 1.01, 95% CI: 0.51-2.00, p = 0.97). During the median follow-up period of 872 days after the index ST events, patients with cancer history showed a higher mortality than those without, among both ST cases (hazard ratio [HR]: 1.93, 95% CI: 1.06-3.51, p = 0.031) and controls (HR: 1.93, 95% CI: 1.09-3.40, p = 0.023). CONCLUSION: A post hoc analysis of REAL-ST registry revealed that patients with G2-ST had a higher prevalence of currently diagnosed and currently treated cancer. Notably, cancer history was associated with the occurrence of late and very late ST, but not with early ST.
    May 2023, Thrombosis journal, 21(1) (1), 60 - 60, English, International magazine
    Scientific journal

  • Ko Yamamoto, Hiroki Shiomi, Takeshi Morimoto, Akiyoshi Miyazawa, Hiroki Watanabe, Masahiro Natsuaki, Hirotoshi Watanabe, Kyohei Yamaji, Masanobu Ohya, Sunao Nakamura, Satoru Mitomo, Satoru Suwa, Takenori Domei, Shojiro Tatsushima, Koh Ono, Hiroki Sakamoto, Kiyotaka Shimamura, Masataka Shigetoshi, Ryoji Taniguchi, Yuji Nishimoto, Hideki Okayama, Kensho Matsuda, Takafumi Yokomatsu, Masahiro Muto, Ren Kawaguchi, Koichi Kishi, Mitsuyoshi Hadase, Tsutomu Fujita, Yasunori Nishida, Masami Nishino, Hiromasa Otake, Nobuhiro Suematsu, Tsuneki Ajimi, Kengo Tanabe, Mitsuru Abe, Kiyoshi Hibi, Kazushige Kadota, Kenji Ando, Takeshi Kimura
    BACKGROUND: Several stent expansion criteria derived from the intravascular ultrasound (IVUS) evaluation have been proposed to predict future clinical outcomes, but optimal stent expansion criteria as a guide during percutaneous coronary intervention (PCI) are still controversial. There are no studies evaluating the utility of stent expansion criteria along with the clinical and procedural factors in predicting target lesion revascularization (TLR) after contemporary IVUS-guided PCI. METHODS: OPTIVUS-Complex PCI study (Optimal Intravascular Ultrasound Guided Complex Percutaneous Coronary Intervention) multivessel cohort was a prospective multicenter study enrolling 961 patients undergoing multivessel PCI including left anterior descending coronary artery using IVUS with an intention to meet the prespecified criteria for optimal stent expansion. We compared several stent expansion criteria (minimum stent area [MSA], MSA/distal or average reference lumen area, MSA/distal or average reference vessel area, OPTIVUS criteria, IVUS-XPL [Impact of Intravascular Ultrasound Guidance on Outcomes of Xience Prime Stents in Long Lesions] criteria, ULTIMATE [Intravascular Ultrasound Guided Drug Eluting Stents Implantation in "All-Comers" Coronary Lesions] criteria, and modified MUSIC [Multicenter Ultrasound Stenting in Coronaries Study] criteria) as well as clinical, angiographic, and procedural characteristics between lesions with and without TLR. RESULTS: Among 1957 lesions, the cumulative 1-year incidence of lesion-based TLR was 1.6% (30 lesions). Hemodialysis, treatment of proximal left anterior descending coronary artery lesions, calcified lesions, small proximal reference lumen area, and small MSA had univariate associations with TLR, while all of the stent expansion criteria except for MSA were not associated with TLR. The independent risk factors of TLR were calcified lesions (hazard ratio, 2.34 [95% CI, 1.03-5.32]; P=0.04) and small proximal reference lumen area (Tertile 1: hazard ratio, 7.01 [95% CI, 1.45-33.93]; P=0.02; and Tertile 2: hazard ratio, 5.40 [95% CI, 1.17-24.90]; P=0.03). CONCLUSIONS: In contemporary IVUS-guided PCI practice, the 1-year incidence of TLR was very low. MSA, but not other stent expansion criteria, had univariate association with TLR. Independent risk factors of TLR were calcified lesions and small proximal reference lumen area, although the findings should be interpreted with caution due to small number of TLR events, limited lesion complexity, and short duration of follow-up.
    May 2023, Circulation. Cardiovascular interventions, 16(5) (5), e012922, English, International magazine
    Scientific journal

  • Ko Yamamoto, Hiroki Shiomi, Takeshi Morimoto, Hiroki Watanabe, Akiyoshi Miyazawa, Kyohei Yamaji, Masanobu Ohya, Sunao Nakamura, Satoru Mitomo, Satoru Suwa, Takenori Domei, Shojiro Tatsushima, Koh Ono, Hiroki Sakamoto, Kiyotaka Shimamura, Masataka Shigetoshi, Ryoji Taniguchi, Yuji Nishimoto, Hideki Okayama, Kensho Matsuda, Takafumi Yokomatsu, Masahiro Muto, Ren Kawaguchi, Koichi Kishi, Mitsuyoshi Hadase, Tsutomu Fujita, Yasunori Nishida, Masami Nishino, Hiromasa Otake, Kengo Tanabe, Mitsuru Abe, Kiyoshi Hibi, Kazushige Kadota, Kenji Ando, Takeshi Kimura
    BACKGROUND: Intravascular ultrasound (IVUS) was only rarely used in landmark trials comparing percutaneous coronary intervention (PCI) with coronary artery bypass grafting (CABG) in patients with multivessel disease. OBJECTIVES: The authors aimed to evaluate clinical outcomes after optimal IVUS-guided PCI in patients undergoing multivessel PCI. METHODS: The OPTIVUS (OPTimal IntraVascular UltraSound)-Complex PCI study multivessel cohort was a prospective multicenter single-arm study enrolling 1,021 patients undergoing multivessel PCI, including left anterior descending coronary artery using IVUS, aiming to meet the prespecified criteria (OPTIVUS criteria: minimum stent area > distal reference lumen area [stent length ≥28mm], and minimum stent area >0.8 × average reference lumen area [stent length <28mm]) for optimal stent expansion. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCE) (death/myocardial infarction/stroke/any coronary revascularization). The predefined performance goals were derived from the CREDO-Kyoto (Coronary REvascularization Demonstrating Outcome study in Kyoto) PCI/CABG registry cohort-2 fulfilling the inclusion criteria in this study. RESULTS: In this study, 40.1% of the patients met OPTIVUS criteria in all stented lesions. The cumulative 1-year incidence of the primary endpoint was 10.3% (95% CI: 8.4%-12.2%), which was significantly lower than the predefined PCI performance goal of 27.5% (P < 0.001), and which was numerically lower than the predefined CABG performance goal of 13.8%. The cumulative 1-year incidence of the primary endpoint was not significantly different regardless of meeting or not meeting OPTIVUS criteria. CONCLUSIONS: Contemporary PCI practice conducted in the OPTIVUS-Complex PCI study multivessel cohort was associated with a significantly lower MACCE rate than the predefined PCI performance goal, and with a numerically lower MACCE rate than the predefined CABG performance goal at 1 year.
    Apr. 2023, JACC. Asia, 3(2) (2), 211 - 225, English, International magazine
    Scientific journal

  • Tomoyo Hamana, Hiroyuki Kawamori, Takayoshi Toba, Shunsuke Kakizaki, Koichi Nakamura, Daichi Fujimoto, Satoru Sasaki, Hiroyuki Fujii, Yuto Osumi, Tomoo Fujioka, Makoto Nishimori, Amane Kozuki, Junya Shite, Masamichi Iwasaki, Tomofumi Takaya, Ken-Ichi Hirata, Hiromasa Otake
    BACKGROUND: Evidence of prognostic factors for stent failure after drug-eluting stent implantation for calcified nodules (CNs) is limited. AIMS: We aimed to clarify the prognostic risk factors associated with stent failure among patients who underwent drug-eluting stent implantation for CN lesions using optical coherence tomography (OCT). METHODS: This retrospective, multicentre, observational study included 108 consecutive patients with CNs who underwent OCT-guided percutaneous coronary intervention (PCI). To evaluate the quality of CNs, we measured their signal intensity and analysed the degree of signal attenuation. All CN lesions were divided into dark or bright CNs according to the half width of signal attenuation, greater or lower than 332, respectively. RESULTS: During the median follow-up period of 523 days, 25 patients (23.1%) experienced target lesion revascularisation (TLR). The 5-year cumulative incidence of TLR was 32.6%. Multivariable Cox regression analysis revealed that younger age, haemodialysis, eruptive CNs, dark CNs assessed by pre-PCI OCT, disrupted fibrous tissue protrusions, and irregular protrusions assessed by post-PCI OCT were independently associated with TLR. The prevalence of in-stent CNs (IS-CNs) observed at follow-up OCT was significantly higher in the TLR group than in the non-TLR group. CONCLUSIONS: Factors such as younger age, haemodialysis, eruptive CNs, dark CNs, disrupted fibrous tissue, or irregular protrusions were independently related to TLR in patients with CNs. The high prevalence of IS-CNs might indicate that the main cause of stent failure implanted in CN lesions could be the recurrence of CN progression in the stented segment.
    Mar. 2023, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, English, International magazine
    Scientific journal

  • Diagnostic Accuracy of Nitroglycerin-free FFRCT-based Physiological Assessment in Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement(タイトル和訳中)
    佐々木 諭, 大竹 寛雅, 川森 裕之, 鳥羽 敬義, 竹重 遼, 福山 裕介, 柿崎 俊介, 中村 公一, 藤本 大地, 藤井 寛之, 濱名 智世, 大隅 祐人, 山本 哲也, 藤岡 知夫, 岩根 成豪, 浪花 祥太, 坂本 優樹, 松濱 考志, 福石 悠太, 新家 俊郎, 平田 健一
    (一社)日本循環器学会, Mar. 2023, 日本循環器学会学術集会抄録集, 87回, PJ094 - 4, English

  • Shimpei Nakatani, Yohei Sotomi, Hiromasa Otake, Yoshihiro Morino, Yoshiharu Higuchi
    Feb. 2023, Circulation journal : official journal of the Japanese Circulation Society, English, Domestic magazine
    Scientific journal

  • Yusuke Fukuyama, Hiromasa Otake, Fumiyasu Seike, Hiroyuki Kawamori, Takayoshi Toba, Yu Takahashi, Kyohei Sasabe, Keisuke Kimura, Junya Shite, Amane Kozuki, Masamichi Iwasaki, Tomofumi Takaya, Kazunori Yasuda, Osamu Yamaguchi, Ken-ichi Hirata
    Springer Science and Business Media LLC, Jan. 2023, Heart and Vessels, 38(5) (5), 634 - 644
    Scientific journal

  • Marta Belmonte, Michael Maeng, Carlos Collet, Bjarne L Norgaard, Hiromasa Otake, Brian Ko, Bon-Kwon Koo, Takuya Mizukami, Adam Updegrove, Emanuele Barbato, Bernard De Bruyne, Jonathon Leipsic, Charles Taylor, Daniele Andreini, Jeroen Sonck
    2023, Journal of cardiovascular computed tomography, 17(5) (5), 367 - 369, English, International magazine

  • Takuya Mizukami, Jeroen Sonck, Koshiro Sakai, Brian Ko, Michael Maeng, Hiromasa Otake, Bon-Kwon Koo, Sakura Nagumo, Bjarne Nørgaard, Jonathon Leipsic, Toshiro Shinke, Daniel Munhoz, Niya Mileva, Marta Belmonte, Hirofumi Ohashi, Emanuele Barbato, Nils P Johnson, Bernard De Bruyne, Carlos Collet
    Background Coronary artery disease (CAD) patterns play an essential role in the decision-making process about revascularization. The pullback pressure gradient (PPG) quantifies CAD patterns as either focal or diffuse based on fractional flow reserve (FFR) pullbacks. The objective of this study was to evaluate the impact of CAD patterns on acute percutaneous coronary intervention (PCI) results considered surrogates of clinical outcomes. Methods and Results This was a prospective, multicenter study of patients with hemodynamically significant CAD undergoing PCI. Motorized FFR pullbacks and optical coherence tomography (OCT) were performed before and after PCI. Post-PCI FFR >0.90 was considered an optimal result. Focal disease was defined as PPG >0.73 (highest PPG tertile). Overall, 113 patients (116 vessels) were included. Patients with focal disease were younger than those with diffuse CAD (61.4±9.9 versus 65.1±8.7 years, P=0.042). PCI in vessels with high PPG (focal CAD) resulted in higher post-PCI FFR (0.91±0.07 in the focal group versus 0.86±0.05 in the diffuse group, P<0.001) and larger minimal stent area (6.3±2.3 mm2 in focal versus 5.3±1.8 mm2 in diffuse CAD, P=0.015) compared withvessels with low PPG (diffuse CAD). The PPG was associated with the change in FFR after PCI (R2=0.51, P<0.001). The PPG significantly improved the capacity to predict optimal PCI results compared with an angiographic assessment of CAD patterns (area under the curvePPG 0.81 [95% CI, 0.73-0.88] versus area under the curveangio 0.51 [95% CI, 0.42-0.60]; P<0.001). Conclusions PCI in vessels with focal disease defined by the PPG resulted in greater improvement in epicardial conductance and larger minimal stent area compared with diffuse disease. PPG, but not angiographically defined CAD patterns, distinguished patients attaining superior procedural outcomes. Registration URL: https://clinicaltrials.gov/ct2/show/NCT03782688.
    Nov. 2022, Journal of the American Heart Association, e026960, English, International magazine
    Scientific journal

  • Shimpei Nakatani, Yohei Sotomi, Satoshi Suzuki, Tomoaki Kobayashi, Yuma Hamanaka, Takashi Omatsu, Masaru Ishida, Shunsuke Kakizaki, Hiromasa Otake, Yoshihiro Morino, Yoshiharu Higuchi
    BACKGROUND: The vessel healing process after implantation of biodegradable polymer (BP) and durable polymer (DP) everolimus-eluting stent (EES) in ST-elevation myocardial infarction (STEMI) lesions remains unclear.Methods and Results: We conducted a multicenter prospective randomized controlled trial to compare early (2 weeks) and mid-term (12 months) vascular responses after implantation of BP-EES vs. DP-EES in STEMI patients. In this prespecified subanalysis, serial coronary angioscopy (CAS) analysis was performed in 15 stents in the BP-EES arm (n=10 patients) and 14 stents in the DP-EES arm (n=10 patients). At the 2-week follow-up, there was no significant difference in the estimated marginal means of the neointimal coverage grade (primary endpoint) between the 2 arms (mean [±SE] 0.00±0.00 in both arms; P>0.999). There were no significant differences between the BP-EES and DP-EES groups in the yellow color grade (1.046±0.106 vs. 0.844±0.114, respectively; P=0.201) or the presence of thrombus (77.8% vs. 88.8%, respectively; P=0.205). At 12 months, competent strut coverage, defined as yellow color grade ≤1, no thrombus, and a neointimal coverage grade ≥1 was achieved more frequently in the BP-EES than DP-EES arm (85.2% vs. 53.1%; adjusted odds ratio 2.11 [95% confidence interval 1.26-3.53]; P=0.023). CONCLUSIONS: Neointimal coverage 2 weeks after implantation of BP-EES and DP-EES in STEMI lesions was comparable on CAS evaluation. However, at 1 year, BP-EES was independently associated with competent strut coverage.
    Nov. 2022, Circulation journal : official journal of the Japanese Circulation Society, English, Domestic magazine
    Scientific journal

  • Shunsuke Kakizaki, Hiromasa Otake, Fumiyasu Seike, Hiroyuki Kawamori, Takayoshi Toba, Shinsuke Nakano, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Daichi Fujimoto, Koichi Nakamura, Hiroyuki Fujii, Amane Kozuki, Junya Shite, Masamichi Iwasaki, Tomofumi Takaya, Osamu Yamaguchi, Ken-Ichi Hirata
    BACKGROUND: Optical coherence tomography-derived fractional flow reserve (OCT-FFR) correlates strongly with wire-based FFR; however, its clinical significance remains uncertain. OBJECTIVES: This study sought to investigate the relationship between post-percutaneous coronary intervention (PCI) OCT-FFR and long-term clinical outcomes in acute coronary syndrome (ACS). METHODS: This retrospective, multicenter, observational cohort study included consecutive patients with ACS who underwent OCT-guided emergency PCI. We analyzed post-PCI OCT images and calculated OCT-FFR to identify independent factors associated with target vessel failure (TVF) after PCI. RESULTS: Among 364 enrolled patients, 54 experienced TVF during a median follow-up of 36 (IQR: 26-48) months. Vessel-level OCT-FFR was significantly lower in the TVF group than in the non-TVF group (0.87 vs 0.94; P < 0.001). In the multivariable Cox regression analysis, low vessel-level OCT-FFR (HR per 0.1 increase: 0.38; 95% CI: 0.29-0.49; P < 0.001) and thin-cap fibroatheroma in the nonculprit lesion were independently associated with TVF. The TVF rate of vessels with both low vessel-level OCT-FFR (<0.90) and thin-cap fibroatheroma in the nonculprit lesion was 8.1 times higher than that of all other vessels (69.3% vs 12.4%; HR: 8.13; 95% CI: 4.33-15.25; log-rank P < 0.001). Furthermore, adding vessel-level OCT-FFR to baseline characteristics and post-PCI OCT findings improved discriminatory and reclassification ability in identifying patients with subsequent TVF. CONCLUSIONS: Vessel-level OCT-FFR was an independent factor associated with TVF after PCI in patients with ACS. Adding the OCT-FFR measurement to post-PCI OCT findings may enable better discrimination of patients with subsequent TVF after PCI for ACS. (Relationship between Intracoronary Optical Coherence Tomography Derived Virtual Fractional Flow Reserve and cardiovascular outcome on Acute coronary syndrome; UMIN000043858).
    Oct. 2022, JACC. Cardiovascular interventions, 15(20) (20), 2035 - 2048, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hirofumi Ohashi, Niya Mileva, Pasquale Paolisso, Jonathon Leipsic, Takuya Mizukami, Jeroen Sonck, Bjarne Norgaard, Hiromasa Otake, Brian Ko, Michael Maeng, Koshiro Sakai, Daniel Munhoz, Sakura Nagumo, Marta Belmonte, Dobrin Vassilev, Emanuele Barbato, Bon-Kwon Koo, Bernard De Bruyne, Carlos Collet
    Elsevier BV, Sep. 2022, Journal of the American College of Cardiology, 80(12) (12), B109 - B110
    Scientific journal

  • Hirofumi Ohashi, Takuya Mizukami, Michael Maeng, Hiromasa Otake, Bon-Kwon Koo, Bjarne Nørgaard, Koshiro Sakai, Daniel Munhoz, Sakura Nagumo, Marta Belmonte, Ruiko Seki, Tatyana Storozhenko, Bernard De Bruyne, Carlos Collet, Brian Ko
    Elsevier BV, Sep. 2022, Journal of the American College of Cardiology, 80(12) (12), B111 - B112
    Scientific journal

  • Hiromasa Otake, Masaru Ishida, Shinsuke Nakano, Yoshiharu Higuchi, Kiyoshi Hibi, Nehiro Kuriyama, Masamichi Iwasaki, Toru Kataoka, Takashi Kubo, Kenichi Tsujita, Takashi Ashikaga, Toshiro Shinke, Tomonori Itoh, Takumi Kimura, Yoshihiro Morino
    The early and mid-term arterial healing profile of biodegradable polymer-coated everolimus-eluting stents (BP-EES) is unclear, especially in ST-segment elevation myocardial infarction (STEMI) culprit lesions. This study aimed to compare early- and mid-term arterial healing between durable polymer-coated everolimus-eluting stents (DP-EES) and BP-EES in STEMI patients. In a prospective, multicenter, non-inferiority trial, STEMI patients were randomized to receive BP-EES (n = 60) or DP-EES (n = 60). The primary endpoint of this study was the mean percentage of covered struts (%covered struts) on FD-OCT 2 weeks post-PCI. Key secondary endpoints included the percentage of uncovered struts, frequency of abnormal intra-stent tissue, and percentage of malapposed struts by FD-OCT 2 weeks and 12 months post-PCI. They underwent serial frequency-domain optical coherence tomography (FD-OCT) evaluations immediately after percutaneous coronary intervention, and at 2 weeks and at 12 months after the procedure. The primary endpoint of %covered struts at 2 weeks was 71.4% in BP-EES and 72.3% in DP-EES [risk difference - 0.94%, lower limit of one-sided 95% confidence interval (CI) - 5.6; Pnon-inferiority = 0.0756]. At 12 months, the mean percentage of uncovered struts was significantly lower [1.73% (95% CI 0.28-3.17) vs. 4.81% (95% CI 3.52-6.09); p = 0.002], and the average malapposed volume was significantly smaller in the BP-EES group than in the DP-EES group (p = 0.002). At 12 months, BP-EES had a significantly larger average neointimal area with a significantly smaller average intra-stent tissue unevenness score than DP-EES, suggesting more uniform neointimal coverage with BP-EES. Strut coverage was comparable between BP-EES and DP-EES at 2 weeks. Non-inferiority could not be proven because of an insufficient sample size. The significantly better arterial healing with BP-EES at 12 months suggests a safer profile for STEMI culprit lesions.Trial registration: jRCTs022180024 https://jrct.niph.go.jp/en-latest-detail/jRCTs022180024.
    Jul. 2022, Cardiovascular intervention and therapeutics, 38(1) (1), 75 - 85, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Jeroen Sonck, Sakura Nagumo, Bjarne L Norgaard, Hiromasa Otake, Brian Ko, Jinlong Zhang, Takuya Mizukami, Michael Maeng, Daniele Andreini, Yu Takahashi, Jesper Møller Jensen, Abdul Ihdayhid, Ward Heggermont, Emanuele Barbato, Niya Mileva, Daniel Munhoz, Jozef Bartunek, Adam Updegrove, Amy Collinsworth, Martin Penicka, Lieven Van Hoe, Jonathon Leipsic, Bon-Kwon Koo, Bernard De Bruyne, Carlos Collet
    BACKGROUND: Low fractional flow reserve (FFR) values after percutaneous coronary intervention (PCI) carry a worse prognosis than high post-PCI FFR values. Therefore, the ability to predict post-PCI FFR might play an important role in procedural planning. Post-PCI FFR values can now be computed from pre-PCI coronary computed tomography angiography (CTA) using the fractional flow reserve derived from coronary computed tomography angiography revascularization planner (FFRCT Planner). OBJECTIVES: The aim of this study was to validate the accuracy of the FFRCT Planner. METHODS: In this multicenter, investigator-initiated, prospective study, patients with chronic coronary syndromes and significant lesions based on invasive FFR ≤0.80 were recruited. The FFRCT Planner was applied to the fractional flow reserve derived from coronary computed tomography angiography (FFRCT) model, simulating PCI. The primary objective was the agreement between the predicted post-PCI FFR by the FFRCT Planner and measured post-PCI FFR. Accuracy of the FFRCT Planner's luminal dimensions was assessed by using post-PCI optical coherence tomography as the reference. RESULTS: Overall, 259 patients were screened, with 120 patients (123 vessels) included in the final analysis. The mean patient age was 64 ± 9 years, and 24% had diabetes. Measured FFR post-PCI was 0.88 ± 0.06, and the FFRCT Planner FFR was 0.86 ± 0.06 (mean difference: 0.02 ± 0.07 FFR unit; limits of agreement: -0.12 to 0.15). Optical coherence tomography minimal stent area was 5.60 ± 2.01 mm2, and FFRCT Planner minimal stent area was 5.0 ± 2.2 mm2 (mean difference: 0.66 ± 1.21 mm2; limits of agreement: -1.7 to 3.0). The accuracy and precision of the FFRCT Planner remained high in cases with focal and diffuse disease and with low and high calcium burden. CONCLUSIONS: The FFRCT-based technology was accurate and precise for predicting FFR after PCI. (Precise Percutaneous Coronary Intervention Plan Study [P3]; NCT03782688).
    Jul. 2022, JACC. Cardiovascular imaging, 15(7) (7), 1242 - 1255, English, International magazine
    Scientific journal

  • Koichi Nakamura, Takayoshi Toba, Hiromasa Otake, Shunsuke Kakizaki, Daichi Fujimoto, Yu Takahashi, Yusuke Fukuyama, Hiroyuki Kawamori, Hidekazu Tanaka, Tomofumi Takaya, Masamichi Iwasaki, Amane Kozuki, Hiroya Kawai, Takatoshi Hayashi, Junya Shite, Ken-Ichi Hirata
    Percutaneous transluminal septal myocardial ablation (PTSMA) is a well-established interventional therapy for drug-refractory hypertrophic obstructive cardiomyopathy (HOCM) as an alternative to surgical myectomy. Although guidelines recommend that PTSMA should be performed in institutions with extensive experience, it is not centralized to such high-volume centers in real-world clinical practice. Thus, this study aimed to assess the feasibility of PTSMA in non-high-volume centers. We retrospectively examined patients with HOCM who underwent PTSMA between August 2012 and May 2020 at four institutions that experienced fewer than 20 cases of PTSMA procedures. The primary clinical endpoint was a composite of safety (all-cause death, electrical defibrillation for ventricular tachycardia or fibrillation, cardiac tamponade, permanent pacemaker implantation, and repeated interventions) and efficacy endpoints (repeated interventions [PTSMA or surgical myectomy]). Fifty-eight consecutive patients were enrolled. During the 30-day follow-up, no major clinical adverse events were noted except three patients (5.2%) requiring permanent pacemaker implantation for complete atrioventricular block. The percentage of patients with New York Heart Association functional class 1 or 2 significantly increased from 8.6 to 100% (p < 0.001). In the Cox proportional hazard model, left ventricular outflow tract pressure gradient at rest ≥ 30 mmHg (hazard ratio [HR] 6.56; 95% confidence interval [CI] 1.44-29.90; p = 0.015) and mitral regurgitation grade ≥ 3 (HR 10.75; 95% CI 1.81-63.79; p = 0.009) at the 30-day follow-up were associated with a composite of major clinical adverse events. The current study demonstrated that 58 patients who underwent PTSMA in non-high-volume centers had favorable 30-day clinical outcomes, with a primary composite endpoint rate of 5.2%. A prospective study with a larger sample size and longer follow-up is warranted to verify the safety and efficacy of PTSMA in non-high-volume centers.
    May 2022, Heart and vessels, English, Domestic magazine
    Scientific journal

  • Takuo Emoto, Hiroyuki Yamamoto, Tomoya Yamashita, Tomofumi Takaya, Takahiro Sawada, Shintaro Takeda, Masayuki Taniguchi, Naoto Sasaki, Naofumi Yoshida, Yoshihiro Saito, Tharini Sivasubramaniyam, Hiromasa Otake, Tomoyuki Furuyashiki, Clinton S Robbins, Hiroya Kawai, Ken-Ichi Hirata
    May 2022, Circulation, 145(18) (18), 1434 - 1436, English, International magazine

  • Kenichi Fujii, Takashi Kubo, Hiromasa Otake, Gaku Nakazawa, Shinjo Sonoda, Kiyoshi Hibi, Toshiro Shinke, Yoshio Kobayashi, Yuji Ikari, Takashi Akasaka
    In this updated expert consensus document, the methods for the quantitative measurement and morphological assessment of optical coherence tomography (OCT)/optical frequency domain imaging images (OFDI) are briefly summarized. The focus is on the clinical application and the clinical evidence of OCT/OFDI to guide percutaneous coronary interventions.
    Apr. 2022, Cardiovascular intervention and therapeutics, 37(2) (2), 248 - 254, English, Domestic magazine
    Scientific journal

  • Yoshinobu Murasato, Yusuke Watanabe, Masahiro Yamawaki, Yoshihisa Kinoshita, Munenori Okubo, Kazuhiko Yumoto, Naoki Masuda, Hiromasa Otake, Jiro Aoki, Gaku Nakazawa, Yohei Numasawa, Tatsuya Ito, Junya Shite, Takayuki Okamura, Kensuke Takagi, Kayoko Kozuma, Thierry Lefèvre, Bernard Chevalier, Yves Louvard, Nobuaki Suzuki, Ken Kozuma
    OBJECTIVE: We investigated the effect of proximal optimization technique (POT) on coronary bifurcation stent failure (BSF) in cross-over stenting by comparing with the kissing balloon technique (KBT) in a multicenter randomized PROPOT trial. BACKGROUND: POT is recommended due to increased certainty for optimal stent expansion and side branch (SB) wiring. METHODS: We randomized 120 patients treated with crossover stenting into the POT group, which was followed by SB dilation (SBD), and the KBT group. Finally, 52 and 57 patients were analyzed by optical coherence tomography before SBD and at the final procedure, respectively. Composite BSF was defined as a maximal malapposition distance of >400 μm, or malapposed and SB-jailed strut rates of >5.95% and >21.4%, respectively. RESULTS: Composite BSF before SBD in the POT and KBT groups was observed in 29% and 26% of patients, respectively. In the POT group, differences in stent volumetric index between the proximal and distal bifurcation (odds ratio [OR] 60.35, 95% confidential interval [CI] 0.13-0.93, p = 0.036) and between the proximal bifurcation and bifurcation core (OR: 3.68, 95% CI: 1.01-13.40, p = 0.048) were identified as independent risk factors. Composite BSF at final in 27% and 32%, and unplanned additional procedures in 38% and 25% were observed, respectively. Composite BSF before SBD was a risk factor for the former (OR: 6.33, 95% CI: 1.10-36.50, p = 0.039) and the latter (OR: 6.43, 95% CI: 1.25-33.10, p = 0.026) in the POT group. CONCLUSION: POT did not result in a favorable trend in BSF. Insufficient expansion of the bifurcation core after POT was associated with BSF.
    Mar. 2022, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 99(4) (4), 1047 - 1058, English, International magazine
    Scientific journal

  • Tomoyo Hamana, Wataru Fujimoto, Akihide Konishi, Makoto Takemoto, Koji Kuroda, Soichiro Yamashita, Junichi Imanishi, Masamichi Iwasaki, Takashi Todoroki, Masanori Okuda, Takatoshi Hayashi, Hiromasa Otake, Hidekazu Tanaka, Masakazu Shinohara, Ryuji Toh, Ken-Ichi Hirata
    Objective Previous studies have described several prognostic factors for heart failure (HF); however, these results were derived from registries consisting of conventional age groups, which might not represent the increasingly aging society. The present study explored the prognostic factors for all-cause death in hospitalized patients with HF across different age categories using an acute HF registry that included relatively old patients. Methods From a total of 1,971 consecutive patients with HF, 1,136 patients were enrolled. We divided the patients into 4 groups (≤65, 66-75, 76-85, and >85 years old) to evaluate all-cause death and prognostic factors of all-cause death. Results During the mean follow-up period of 1,038 days, 445 patients (39.2%) had all-cause death. A Kaplan-Meier analysis demonstrated significantly higher incidence of all-cause death in the elderly groups than in the younger groups (log-rank p<0.001). A Cox proportional-hazard regression analysis revealed that the presence of atrial fibrillation [hazard ratio (HR): 23.3, 95% confidence interval (CI): 2.36-231.1, p=0.007] was a notable predictive factor for all-cause death in the ≤65 years old group, whereas the Clinical Frailty Scale score (HR: 1.33, 95% CI: 1.16-1.52, p<0.001) and hypoalbuminemia (HR: 0.49, 95% CI: 0.31-0.78, p=0.003) were predictors in the >85 years old group. Conclusions Atrial fibrillation was a notable predictor of HF in young patients, whereas frailty and low-grade albuminemia were essential predictive factors of HF in elderly patients. With the increasing number of elderly patients with HF, comprehensive multidisciplinary treatment will be necessary.
    2022, Internal medicine (Tokyo, Japan), 61(21) (21), 3171 - 3180, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Ryo Takeshige, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-Ichi Yanaka, Hiroyuki Yamamoto, Akira Nagasawa, Hiroyuki Onishi, Yoichiro Sugizaki, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Ken-Ichi Hirata
    The initial process of atherosclerotic development has not been systematically evaluated. This study aimed to observe atherosclerotic progression from normal vessel wall (NVW) to atherosclerotic plaque and examine local factors associated with such progression using > 5-year long-term follow-up data obtained by serial optical coherence tomography (OCT). A total of 49 patients who underwent serial OCT for lesions with NVW over 5 years (average: 6.9 years) were enrolled. NVW was defined as a vessel wall with an OCT-detectable three-layer structure and intimal thickness ≤ 300 μm. Baseline and follow-up OCT images were matched, and OCT cross sections with NVW > 30° were enrolled. Cross sections were diagnosed as "progression" when the NVW in these cross sections was reduced by > 30° at > 5-year follow-up. Atherogenic progression from NVW to atherosclerotic plaque was observed in 40.8% of enrolled cross sections. The incidence of microchannels in an adjacent atherosclerotic plaque within the same cross section (6.7 vs. 3.3%; p = 0.046) and eccentric distribution of atherosclerotic plaque (25.0 vs. 12.6%; p < 0.001) at baseline was significantly higher in cross sections with progression than in those without. Cross sections with progression exhibited significantly higher NVW intimal thickness at baseline than cross sections without progression (200.1 ± 53.7 vs. 180.2 ± 59.6 μm; p < 0.001). Multivariate analysis revealed that the presence of microchannels in an adjacent atherosclerotic plaque, eccentric distribution of atherosclerotic plaque, and greater NVW intimal thickness at baseline were independently associated with progression at follow-up. The presence of microchannels in an adjacent atherosclerotic plaque, eccentric distribution of atherosclerotic plaque, and greater NVW intimal thickness were potentially associated with initial atherosclerotic development from NVW to atherosclerotic plaque.
    Jan. 2022, Heart and vessels, 37(1) (1), 1 - 11, English, Domestic magazine
    Scientific journal

  • Hiroshi Fujita, Takayoshi Toba, Keisuke Miwa, Masataka Suzuki, Yu Takahashi, Hiroyuki Toh, Yu Izawa, Hiroyuki Kawamori, Hiromasa Otake, Sei Fujiwara, Yoshiaki Watanabe, Atsushi Kono, Ken-Ichi Hirata
    BACKGROUND: The impact of the extent of aortic atheroma on patients' prognosis after transcatheter aortic valve replacement (TAVR) has not been completely evaluated. This study aimed to evaluate the prognostic value of the aortic atheroma volume (AAV) derived from computed tomography, and the effect of its differences among the segments of the aorta, in patients undergoing TAVR. METHODS: In total, 143 patients with symptomatic severe aortic stenosis who underwent pre-procedural computed tomography before TAVR procedure indication were evaluated. AAV was calculated by measuring the aortic lumen and vessel volume using every 1-mm axial image and was further divided into thoracic (TAAV) and abdominal segments (AbAAV). RESULTS: During a median follow-up of 651 days, 24 all-cause and 14 cardiac deaths occurred. In the Kaplan-Meier analysis, the high AAV group had significantly higher all-cause and cardiac mortalities than the low AAV group (p = 0.016 and 0.023, respectively). Regarding segmental AAV, all-cause and cardiac mortalities did not have significant differences between the high and low TAAV groups. Moreover, all-cause and cardiac mortalities were significantly higher in the high AbAAV group than in the low AbAAV group (p = 0.0043 and 0.023, respectively). The multivariable analysis showed that only AbAAV was an independent predictor for all-cause mortality (hazard ratio: 1.06, p = 0.046). CONCLUSION: AAV was significantly associated with the mortality after TAVR. The current study suggests the pre-procedural assessment of AAV is valuable in predicting prognosis after TAVR. However, further investigation with a larger sample size is needed to validate our findings.
    Dec. 2021, International journal of cardiology, 344, 60 - 65, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Daisuke Terashita, Akira Nagasawa, Kousuke Tanimura, Kensuke Matsumoto, Hidekazu Tanaka, Ken-ichi Hirata
    John Wiley and Sons Inc, Nov. 2021, Catheterization and Cardiovascular Interventions, 98(5) (5), E715 - E723, English
    Scientific journal

  • Hiromasa Otake, Tomoyo Hamana
    Oct. 2021, Circulation journal : official journal of the Japanese Circulation Society, 85(11) (11), 2029 - 2031, English, Domestic magazine

  • Masataka Suzuki, Takayoshi Toba, Yu Izawa, Hiroshi Fujita, Keisuke Miwa, Yu Takahashi, Hiroyuki Toh, Hiroyuki Kawamori, Hiromasa Otake, Hidekazu Tanaka, Sei Fujiwara, Yoshiaki Watanabe, Atsushi K Kono, Kenji Okada, Ken-Ichi Hirata
    Background Myocardial extracellular volume fraction (ECV), measured by cardiac magnetic resonance imaging, is a useful prognostic marker for patients who have undergone aortic valve replacement (AVR) for aortic stenosis. However, the prognostic significance of ECV measurements based on computed tomography (CT) is unclear. This study evaluated the association between ECV measured with dual-energy CT and clinical outcomes in patients with aortic stenosis who underwent transcatheter or surgical AVR. Methods and Results We retrospectively enrolled 95 consecutive patients (age, 84.0±5.0 years; 75% women) with severe aortic stenosis who underwent preprocedural CT for transcatheter AVR planning. ECV was measured using iodine density images obtained by delayed enhancement dual-energy CT. The primary end point was a composite outcome of all-cause death and hospitalization for heart failure after AVR. The mean ECV measured with CT was 28.1±3.8%. During a median follow-up of 2.6 years, 22 composite outcomes were observed, including 15 all-cause deaths and 11 hospitalizations for heart failure. In Kaplan-Meier analysis, the high ECV group (≥27.8% [median value]) had significantly higher rates of composite outcomes than the low ECV group (<27.8%) (log-rank test, P=0.012). ECV was the only independent predictor of adverse outcomes on multivariable Cox regression analysis (hazards ratio, 1.25; 95% CI, 1.10‒1.41; P<0.001). Conclusions Myocardial ECV measured with dual-energy CT in patients who underwent aortic valve intervention was an independent predictor of adverse outcomes after AVR.
    Sep. 2021, Journal of the American Heart Association, 10(18) (18), e020655, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Shinsuke Nakano, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yoichiro Sugizaki, Akira Nagasawa, Ryo Takeshige, Yoichiro Matsuoka, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Junya Shite, Amane Kozuki, Masamichi Iwasaki, Koji Kuroda, Tomofumi Takaya, Ken-Ichi Hirata
    Background: The effect of intraindividual variability in lipid levels on the onset of acute coronary syndrome (ACS) remains uncertain. We evaluated the relationship between intraindividual variability in lipid levels and culprit lesion morphologies by optical coherence tomography (OCT). Methods and Results: Seventy-four consecutive patients with ACS whose cholesterol levels were assessed ≥3 times during outpatient visits before the onset of ACS were enrolled in the study; 222 patients without significant stenotic lesions were used as a control group. Based on OCT findings of culprit lesions, ACS patients were categorized into a plaque rupture ACS (PR-ACS) group (n=44) or a non-plaque rupture ACS (NPR-ACS) group (erosion or calcified nodule; n=30). Visit-to-visit variability in lipid levels was evaluated using the corrected variability independent of the mean (cVIM). Patients with ACS had significantly higher low-density lipoprotein cholesterol (LDL-C) levels and cVIM in LDL-C than the control group. The PR-ACS group had significantly higher mean LDL-C levels and greater cVIM in LDL-C than the control group. The PR-ACS group had a significantly higher cVIM than the NPR-ACS group, despite similar mean LDL-C levels. Multivariate analysis revealed that higher cVIM of LDL-C was an independent predictor of PR-ACS (odds ratio 1.06; P=0.018). Conclusions: In addition to the LDL-C level, greater visit-to-visit variability in LDL-C levels may be associated with the onset of ACS induced by plaque rupture.
    Sep. 2021, Circulation reports, 3(9) (9), 540 - 549, English, Domestic magazine
    Scientific journal

  • Kosuke Tanimura, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Akira Nagasawa, Shinsuke Nakano, Yu Takahashi, Yusuke Fukuyama, Amane Kozuki, Junya Shite, Masamichi Iwasaki, Koji Kuroda, Tomofumi Takaya, Ken-Ichi Hirata
    Background Although patients with a cancer history have a 2 to 3 times higher risk for acute coronary syndrome (ACS), the morphological characteristics of ACS culprit plaque in those patients and their relations with clinical outcomes remain unknown. Methods and Results This retrospective, multicenter, observational cohort study included consecutive patients with ACS who underwent optical coherence tomography-guided emergent percutaneous coronary intervention. Patients were categorized into those without a cancer history, those with a cancer history, and those currently receiving cancer treatment. ACS culprit lesions were classified as plaque rupture, plaque erosion, or calcified nodule using optical coherence tomography. Plaque erosion frequency was significantly higher in culprit lesions of patients with current cancer and patients with cancer history than in those of patients without cancer history (56.3% versus 61.7% versus 36.5%). Calcified nodule incidence was significantly higher in patients without cancer history than in patients with current cancer and patients without cancer history (patients with current cancer: 12.4% versus patients without cancer history: 25.5% versus patients without cancer history: 12.6%, P<0.001). Cancer history was independently associated with nonplaque rupture (plaque erosion or calcified nodule) in ACS culprit lesions (odds ratio, 4.00; P<0.001). Cancer history was independently associated with major adverse cardiovascular events (hazard ratio [HR], 1.98; P=0.002). Nonplaque rupture in ACS culprit lesions was independently associated with major adverse cardiovascular events (HR, 1.60; P=0.011). Conclusions Patients with a cancer history had significantly worse clinical outcomes after ACS than those without a cancer history. Those with a cancer history had significantly higher plaque erosion and calcified nodule incidences in the ACS culprit lesions, which might partly explain their worse clinical outcomes. Registration URL: www.umin.ac.jp/ctr/index.htm. Unique Identifier: UMIN000038442.
    Aug. 2021, Journal of the American Heart Association, 10(15) (15), e020243, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takayoshi Toba, Hiroyuki Kawamori, Hiromasa Otake, Ken-Ichi Hirata
    Jun. 2021, Cardiovascular intervention and therapeutics, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Masaru Kuroda, Yushi Hirota, Kazuhiko Sakaguchi, Wataru Ogawa, Ken-Ichi Hirata
    AIMS/INTRODUCTION: Glucose fluctuation (GF) is a residual risk factor for coronary artery disease (CAD). We investigated whether GF influenced clinical outcomes and progression of coronary stenosis in stable CAD patients. MATERIALS AND METHODS: In this prospective study, 101 consecutive lipid-controlled stable CAD patients underwent percutaneous coronary intervention were enrolled, and GF was expressed as the mean amplitude of glycemic excursion (MAGE) obtained by continuous glucose monitoring before the procedure was evaluated. At 9 months after enrollment, culprit and non-culprit (mild-to-moderate stenosis without ischemia) lesions were serially assessed by angiography. Cardiovascular events (CVE) consisting of cardiovascular death, non-fatal myocardial infarction or ischemia-driven revascularization during 2-year follow up, rapid progression in non-culprit lesions (defined as ≥10% luminal narrowing progression in lesions with stenosis ≥50%, ≥30% luminal narrowing progression in non-culprit lesions with stenosis <50% or normal segment, or progression to total occlusion) were evaluated. RESULTS: CVE occurred in 25 patients, and MAGE was significantly higher in the CVE group (76.1 ± 24.8 mg/dL vs 59.3 ± 23.7 mg/dL; P = 0.003). Multivariate analysis showed that MAGE was an independent predictor of CVE (odds ratio 1.027, 95% confidence interval 1.008-1.047; P = 0.005). The optimal MAGE value to predict CVE was 70.7 mg/dL (area under the curve 0.687, 95% confidence interval 0.572-0.802; P = 0.005). Furthermore, MAGE was independently associated with rapid progression, and with the luminal narrowing progression in all non-culprit lesions (r = 0.400, P < 0.05). CONCLUSIONS: Daily GF might influence future CVE in lipid-controlled stable CAD patients.
    Jun. 2021, Journal of diabetes investigation, 12(6) (6), 1015 - 1024, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiroyuki Kawamori, Akihide Konishi, Toshiro Shinke, Hirokuni Akahori, Masaharu Ishihara, Hiroaki Tsujita, Hiromasa Otake, Takayoshi Toba, Shinsuke Nakano, Kosuke Tanimura, Yoshiro Tsukiyama, Isao Nanba, Yasumasa Kakei, Takahiro Yasuda, Takashi Omori, Takashi Kubo, Amane Kozuki, Junya Shite, Ken-Ichi Hirata
    Optical frequency domain imaging (OFDI) is a high-resolution intracoronary imaging modality with fast automated longitudinal pullback. We aimed to evaluate the ability of performing OFDI from the superficial femoral artery (SFA) to the below-knee (BK) artery. This clinical trial was a multi-center, single-arm, open-label study. The primary endpoint was to obtain a clear image of the intra-vascular lumen from the SFA to the BK artery, specifically  > 270° visualization of the blood vessel lumen with  > 16/21 cross sections. The proportion of the clear image (≥ 85%) was regarded as confirmatory of the ability of OFDI to visualize the vessel lumen. Overall, 20 patients were enrolled. The proportion of the primary endpoint was 90% (18/20), and the pre-specified criterion was successfully attained. The proportion of the clear image assessed by the operator was 100% (20/20), and an additional statistical analysis for the proportion of the visualization,  > 270°, of the blood vessel lumen revealed a significantly higher cut-off value than that for the pre-specified criterion, 85% (p = 0.0315). There were three adverse events not related to OFDI. OFDI achieved acceptable visualization of the vessel lumen without any adverse event related to it. After regulatory approval based on the present study, OFDI will be available as a new option of endovascular imaging for peripheral artery diseases in daily practiceTrial registration: This study was registered in the Japanese Registry of Clinical Trials (jRCT 2052190025, https://jrct.niph.go.jp/latest-detail/jRCT2052190025 ).
    Jun. 2021, Heart and vessels, 36(6) (6), 818 - 826, English, Domestic magazine
    Scientific journal

  • Takayoshi Toba, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Naoki Matsukawa, Akira Matsuura, Takayuki Ishihara, Daisuke Matsumoto, Nobuaki Igarashi, Takatoshi Hayashi, Yoshinori Yasaka, Makoto Kadotani, Takashi Fujii, Junya Shite, Masaharu Okada, Takashi Sakakibara, Ken-Ichi Hirata
    BACKGROUND: The impact of antiplatelet drug effects on mid-term local arterial responses following percutaneous coronary intervention (PCI) remains uncertain. We evaluated the impact of the platelet reactivity of prasugrel on mid-term vascular healing between acute coronary syndrome (ACS) and stable coronary artery disease (CAD).Methods and Results:We conducted a prospective, 12-center study in 125 patients with ACS and 126 patients with stable CAD who underwent PCI with an everolimus-eluting stent (EES) and received dual antiplatelet therapy (DAPT) with prasugrel and aspirin. Serial optical coherence tomography (OCT) was performed immediately after PCI and at the 9-month follow-up to assess the association of P2Y12reaction units (PRU) with the frequency of malapposed or uncovered struts and intrastent thrombi (IST). The incidence of abnormal mid-term OCT findings did not different between the ACS and CAD arms, regardless of clinical presentation, except that uncovered struts were more frequent in the ACS than CAD arm. PRU at PCI was significantly associated with the frequency of IST at follow-up, but not with uncovered and malapposed struts. PRU at PCI was the only independent predictor of IST detected at follow-up (odds ratio 1.009). CONCLUSIONS: In patients undergoing EES implantation and receiving prasugrel, achieving an adequate antiplatelet effect at the time of stent implantation may regulate thrombus formation throughout the follow-up period.
    May 2021, Circulation journal : official journal of the Japanese Circulation Society, 85(6) (6), 808 - 816, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Fumi Yamamoto, Masahiro Natsuaki, Shoichi Kuramitsu, Masanobu Ohya, Hiromasa Otake, Kazunori Horie, Futoshi Yamanaka, Hiroki Shiomi, Gaku Nakazawa, Kenji Ando, Kazushige Kadota, Shigeru Saito, Takeshi Kimura, Koichi Node
    OBJECTIVES: The primary objective of the current analysis was to assess the association between the clinical presentation at index procedure and mortality in patients with second-generation drug-eluting stent thrombosis (G2-ST). BACKGROUND: Patients with acute coronary syndrome (ACS) have a higher risk for stent thrombosis (ST) as compared with those with chronic coronary syndrome (CCS). However, clinical outcomes of patients with G2-ST after treatment for ACS and CCS remain poorly understood. METHODS: From the REAL-ST (Retrospective Multicenter Registry of ST After First- and Second-Generation Drug-Eluting Stent Implantation) registry, this study evaluated 313 patients with G2-ST. According to baseline clinical presentation, patients were divided into the 2 groups: the ACS and CCS groups (n = 147 and n = 166, respectively). The primary endpoint was the cumulative 3-year incidence of all-cause death after the index ST events. Timing of ST, target lesion revascularization, and recurrent ST were also assessed. RESULTS: Early ST was more frequently observed in the ACS group (71.4% vs. 44.6%), while very late ST was less likely to occur in the ACS group than in the CCS group (11.6% vs. 30.7%). Cumulative 3-year incidence of all-cause death after the index ST events was comparable between the ACS and CCS groups (28.6% vs. 28.3%; hazard ratio: 1.14; 95% confidence interval: 0.75 to 1.73; p = 0.55). Compared with the CCS group, the ACS group showed higher incidences of target lesion revascularization and recurrent ST (23.8% vs. 17.2%; p = 0.06; and 9.9% vs. 1.4%; p = 0.001, respectively). CONCLUSIONS: Patients with G2-ST were associated with higher mortality irrespective of baseline clinical presentation.
    May 2021, JACC. Cardiovascular interventions, 14(10) (10), 1082 - 1090, English, International magazine
    Scientific journal

  • Makiko Suzuki, Kensuke Matsumoto, Yusuke Tanaka, Kentaro Yamashita, Ayu Shono, Keiko Sumimoto, Nao Shibata, Shun Yokota, Makiko Suto, Kumiko Dokuni, Hidekazu Tanaka, Hiromasa Otake, Ken-Ichi Hirata
    PURPOSES: The closure of atrial septal defect (ASD) is associated with a significant reduction in right ventricular (RV) overload and an improvement in functional capacity in most adults with ASD. However, a subset of patients remains symptomatic even after closure due to therapeutic delay. To date, no clinically robust preoperative predictor of postoperative residual symptoms has been clearly identified. METHODS: In this study, 120 adult patients with ASD and 39 controls were investigated. As an index of RV myocardial deformation, RV global longitudinal strain (RV-GLS) was evaluated. The degree of coupling between RV and pulmonary artery (PA) was quantified by the tricuspid annular plane systolic excursion (TAPSE) divided by the PA systolic pressure (PASP). RESULTS: Compared to controls, baseline RV-GLS was significantly greater (- 27 ± 7 vs. - 23 ± 5%, P = 0.02) and TAPSE/PASP ratio was severely impaired (0.8 ± 0.3 vs. 2.1 ± 1.6 mm/mmHg, P < 0.01) in ASD patients. At 6 months after closure, 15 patients (12.5%) remained symptomatic. In patients without residual symptoms, TAPSE/PASP ratio significantly improved from 0.9 ± 0.3 to 1.0 ± 0.6 mm/mmHg (P = 0.02), and RV-GLS normalized (from - 28 ± 11 to - 24 ± 7%, P < 0.01) after closure. However, RV-GLS and TAPSE/PASP ratio showed no significant change in ASD patients with residual symptoms. On multivariate analysis, preoperative TAPSE/PASP ratio (odds ratio [OR] 0.034, 95% confidence interval [CI] 0.000-0.604, P = 0.03) and pulmonary vascular resistance index ([PVRI], OR 1.011, 95% CI 1.000-1.021, P < 0.05) were associated with the postoperative symptomatic status. CONCLUSION: In terms of integrated assessment of the RV-PA unit, preoperative TAPSE/PASP ratio and PVRI were important determinants of residual symptoms after ASD closure.
    May 2021, The international journal of cardiovascular imaging, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Akira Nagasawa, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yoichiro Sugizaki, Ryo Takeshige, Shinsuke Nakano, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Amane Kozuki, Junya Shite, Masamichi Iwasaki, Koji Kuroda, Tomofumi Takaya, Ken-Ichi Hirata
    Culprit lesions of acute coronary syndrome (ACS) could be classified as plaque rupture (PR), erosion, or calcified nodule (CN). We aimed to determine the relationship among clinical characteristics, morphological plaque features, and long-term prognosis in ACS. Patients with ACS, who underwent pre-intervention optical coherence tomography between April 2013 and July 2018 were retrospectively enrolled, and classified into the three groups based on the culprit lesion morphology. In the 436 patients enrolled, incidences of PR, erosion, and CN in ACS culprit lesions were 46.1, 39.9, and 14.0%, respectively. Plaque erosion was more frequent in men aged < 60 years and CN was more frequent in older adults in both sexes (≥ 80 years) (P < 0.001). Patients with CN had a higher incidence of hemodialysis treatment (P < 0.001) and diabetes (P = 0.003). Multivariate analysis revealed that ST elevation myocardial infarction (STEMI) (P = 0.049) and presence of thin-cap fibroatheroma (TCFA) at the culprit lesion were independently associated with PR; in younger patients (< 60 year), preserved left ventricular ejection fraction and lower incidence of TCFA were correlated with plaque erosion; and older age, non-STEMI, or unstable angina pectoris, higher serum brain natriuretic peptide levels, and lower incidence of TCFA were independently associated with CN. Multivariable analysis revealed that CN (odds ratio [OR] 1.990, P = 0.005), male sex (OR 2.012, P = 0.004), and older age (OR 1.036, P < 0.001) were independently associated with future adverse events during a median follow-up of 757 days. Different patient characteristics and morphological features were associated with the type of culprit lesion in patients with ACS.
    May 2021, The international journal of cardiovascular imaging, English, International magazine
    Scientific journal

  • Soichiro Enomoto, Shoichi Kuramitsu, Tomohiro Shinozaki, Masanobu Ohya, Hiromasa Otake, Futoshi Yamanaka, Hiroki Shiomi, Masahiro Natsuaki, Gaku Nakazawa, Kenji Ando, Kazushige Kadota, Shigeru Saito, Toshihiro Tamura, Takeshi Kimura
    Background Stent thrombosis (ST) after drug-eluting stent (DES) implantation remains a life-threatening complication. Recurrent ST (RST) is not a rare phenomenon, potentially contributing to high mortality after the index ST events. However, little evidence is available about the incidence, risk factors, and clinical outcomes of definite RST after DES thrombosis. Methods and Results From REAL-ST (Retrospective Multicenter Registry of ST After First- and Second- Generation DES Implantation), this study evaluated 595 patients with definite ST (first-generation DES thrombosis, n=314; second-generation DES thrombosis, n=281). During a median follow-up of 31 months, we identified 32 patients with definite RST after first-generation DES thrombosis (n=18) and second-generation DES thrombosis (n=15). Cumulative incidence of RST was 4.5% and 6.0% at 1 and 5 years, respectively, which did not significantly differ between first-generation DES thrombosis and second-generation DES thrombosis. Independent predictors of definite RST were early ST (hazard ratio [HR], 2.38; 95% CI, 1.06-5.35 [P=0.035]) and multivessel ST (HR, 3.47; 95% CI, 1.03-11.7 [P=0.044]). Definite RST was associated with a 2.8-fold increased risk of mortality (adjusted HR, 2.78; 95% CI, 1.35-5.73 [P=0.006]). Conclusions Cumulative incidence of definite RST did not significantly differ between first-generation DES thrombosis and second-generation DES thrombosis. Early ST and multivessel ST were risk factors of definite RST. Definite RST significantly increased mortality after DES thrombosis, highlighting the clinical importance of preventing RST to improve outcomes of patients with ST. Registration URL: https://www.clinicaltrials.gov; Unique identifier: UMIN000025181.
    May 2021, Journal of the American Heart Association, 10(9) (9), e018972, English, International magazine
    Scientific journal

  • Tomonori Itoh, Hiromasa Otake, Takumi Kimura, Yoshiro Tsukiyama, Tatsuo Kikuchi, Munenori Okubo, Takatoshi Hayashi, Takayuki Okamura, Shoichi Kuramitsu, Takashi Morita, Shinjo Sonoda, Shozo Ishihara, Nehiro Kuriyama, Takaaki Isshiki, Tsunenari Soeda, Kiyoshi Hibi, Toshiro Shinke, Yoshihiro Morino
    The purpose of this study was to assess early and late vascular healing in response to bioresorbable-polymer sirolimus-eluting stents (BP-SESs) for the treatment of patients with ST-elevation myocardial infarction (STEMI) and stable coronary artery disease (CAD). A total of 106 patients with STEMI and 101 patients with stable-CAD were enrolled. Optical frequency-domain images were acquired at baseline, at 1- or 3-month follow-up, and at 12-month follow-up. In the STEMI and CAD cohorts, the percentage of uncovered struts (%US) was significantly and remarkably decreased during early two points and at 12-month (the STEMI cohort: 1-month: 18.75 ± 0.78%, 3-month: 10.19 ± 0.77%, 12-month: 1.80 ± 0.72%; p < 0.001, the CAD cohort: 1-month: 9.44 ± 0.78%, 3-month: 7.78 ± 0.78%, 12-month: 1.07 ± 0.73%; p < 0.001 respectively). The average peri-strut low-intensity area (PLIA) score in the STEMI cohort was significantly decreased during follow-up period (1.90 ± 1.14, 1.18 ± 1.25, and 1.01 ± 0.72; p ≤ 0.001), whereas the one in the CAD cohort was not significantly changed (0.89 ± 1.24, 0.67 ± 1.07, and 0.64 ± 0.72; p = 0.59). In comparison with both groups, differences of %US and PLIA score at early two points were almost disappeared or close at 12 months. The strut-coverage and healing processes in the early phase after BP-SES implantation were significantly improved in both cohorts, especially markedly in STEMI patients. At 1 year, qualitatively and quantitatively consistent neointimal coverage was achieved in both pathogenetic groups.
    Apr. 2021, Cardiovascular intervention and therapeutics, 37(2) (2), 281 - 292, English, Domestic magazine
    Scientific journal

  • Kosuke Tanimura, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Akira Nagasawa, Yoichiro Sugizaki, Ryo Takeshige, Shinsuke Nakano, Yoichiro Matsuoka, Yu Takahashi, Yusuke Fukuyama, Ken-Ichi Hirata
    Whether predicting the rotational atherectomy (RA) effect based on the position of optical frequency domain imaging (OFDI) is accurate remains uncertain. The aim of this study was to evaluate the predictive accuracy of OFDI in identifying RA location and area. Twenty-five patients who underwent RA with OFDI were included. On pre-RA OFDI images, a circle with the dimension of a Rota burr was drawn at the center of the OFDI catheter. The area where the circle overlapped with the vessel wall was defined as the predicted ablation area (P-area), and the actual ablated area (A-area) was measured. The predictive accuracy of OFDI was evaluated as follows: overlapped ablation area (O-area: overlapping P- and A-areas) divided by P-area = %Correct-area, and A-area - O-area divided by A-area = %Error-area. Cross-sections were separated into four categories based on the median values of %Correct- and %Error-area. Among 334 cross-sections, RA effects were confirmed in the predicted location in 87% of them. The median %Correct- and %Error-areas were 43.1% and 64.2%, respectively. Floppy wire, narrow lumen area, OFDI catheter close to the intima, and large arc of calcium were independently associated with good prediction (high %Correct-/low %Error-areas). Non-left anterior descending lesions, OFDI catheter far from the wire, and OFDI catheter and wire far from the intima were associated with irrelevant ablation (low %Correct-/ high %Error-areas). The accuracy of the OFDI-based predictions for RA effects was acceptable with regard to location, but not high with regard to area. Wire types, target vessels, and OFDI catheter and wire positions are important determinants for accurately predicting RA effect using pre-procedural OFDI.
    Apr. 2021, Heart and vessels, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yu Takahashi, Takayoshi Toba, Hiromasa Otake, Yusuke Fukuyama, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Yu Izawa, Hiroyuki Kawamori, Atsushi K Kono, Sei Fujiwara, Ken-Ichi Hirata
    To investigate the feasibility of pre-procedural morphological assessment of coronary artery calcification in severely calcified lesions with electrocardiography (ECG)-gated non-contrast computed tomography (CT). Severely calcified coronary arteries in patients who underwent ECG-gated non-contrast CT prior to optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) were studied retrospectively. CT and OCT data were co-registered by marking landmark structures such as side branches and reviewed side by side with cross-sectional images. The maximum calcium angle (MCA) and presence of nodular calcification (NC) were evaluated. A total of 496 cross-sections in 16 lesions were included in this analysis. The Pearson correlation coefficient between CT- and OCT-derived MCA was 0.92 (p < 0.001). Bland-Altman plots of OCT-derived MCA in relation to CT-derived MCA showed a mean bias of 4.8 degrees with 95% limits of agreement of - 69.7 to 79.4 degrees. Sensitivity, specificity, and positive and negative predictive values of CT in identifying MCA > 270 degrees were 90.3%, 79.7%, 92.1%, and 97.4%, respectively. Sensitivity, specificity, and positive and negative predictive values of CT in identifying NC were 73.3%, 97.5%, 47.8%, and 99.2%, respectively. ECG-gated non-contrast coronary CT might be helpful to obtain detailed information of severe coronary artery calcification before PCI.
    Apr. 2021, The international journal of cardiovascular imaging, 37(4) (4), 1445 - 1453, English, International magazine
    Scientific journal

  • Shoichi Kuramitsu, Shinjo Sonoda, Kenji Ando, Hiromasa Otake, Masahiro Natsuaki, Reo Anai, Yasuhiro Honda, Kazushige Kadota, Yoshio Kobayashi, Takeshi Kimura
    Over the past 40 years, the safety and efficacy of percutaneous coronary intervention has dramatically improved by overcoming several challenges. The introduction of drug-eluting stent (DES) in particular was a major breakthrough in interventional cardiology. Compared to bare-metal stents, first-generation DES (G1-DES) has dramatically reduced the rates of in-stent restenosis and subsequent target lesion revascularization. However, major safety concerns surrounding stent thrombosis (ST) emerged with G1-DES in clinical practice as a result of the high incidences of death, myocardial infarction, and repeat revascularization associated with ST. To overcome these limitations, second-generation DES (G2-DES) has been developed with an improved stent platform with thinner strut and biocompatible durable or biodegradable polymers. Indeed, G2-DES, when compared with G1-DES, has improved clinical outcomes by reducing the risk of late thrombotic events while maintaining anti-restenotic efficacy, whereas ST still occurs, even with the use of G2-DES. This review gives an overview of pathophysiology, risk factors, and outcomes of ST after DES implantation. Additionally, we discuss the management and prevention of ST.
    Apr. 2021, Cardiovascular intervention and therapeutics, 36(2) (2), 158 - 168, English, Domestic magazine
    Scientific journal

  • Sakura Nagumo, Carlos Collet, Bjarne L Norgaard, Hiromasa Otake, Brian Ko, Bon-Kwon Koo, Jonathon Leipsic, Daniele Andreini, Ward Heggermont, Jesper M Jensen, Yu Takahashi, Abdul Ihdayhid, Zinlong Zhang, Emanuele Barbato, Michael Maeng, Takuya Mizukami, Jozef Bartunek, Adam Updegrove, Martin Penicka, Campbell Rogers, Charles Taylor, Bernard De Bruyne, Jeroen Sonck
    INTRODUCTION: Fractional flow reserve (FFR) measured after percutaneous coronary intervention (PCI) has been identified as a surrogate marker for vessel related adverse events. FFR can be derived from standard coronary computed tomography angiography (CTA). Moreover, the FFR derived from coronary CTA (FFRCT ) Planner is a tool that simulates PCI providing modeled FFRCT values after stenosis opening. AIM: To validate the accuracy of the FFRCT Planner in predicting FFR after PCI with invasive FFR as a reference standard. METHODS: Prospective, international and multicenter study of patients with chronic coronary syndromes undergoing PCI. Patients will undergo coronary CTA with FFRCT prior to PCI. Combined morphological and functional evaluations with motorized FFR hyperemic pullbacks, and optical coherence tomography (OCT) will be performed before and after PCI. The FFRCT Planner will be applied by an independent core laboratory blinded to invasive data, replicating the invasive procedure. The primary objective is to assess the agreement between the predicted FFRCT post-PCI derived from the Planner and invasive FFR. A total of 127 patients will be included in the study. RESULTS: Patient enrollment started in February 2019. Until December 2020, 100 patients have been included. Mean age was 64.1 ± 9.03, 76% were males and 24% diabetics. The target vessels for PCI were LAD 83%, LCX 6%, and RCA 11%. The final results are expected in 2021. CONCLUSION: This study will determine the accuracy and precision of the FFRCT Planner to predict post-PCI FFR in patients with chronic coronary syndromes undergoing percutaneous revascularization.
    Apr. 2021, Clinical cardiology, 44(4) (4), 446 - 454, English, International magazine
    Scientific journal

  • Yusuke Watanabe, Yoshinobu Murasato, Masahiro Yamawaki, Yoshihisa Kinoshita, Munenori Okubo, Kazuhiko Yumoto, Naoki Masuda, Hiromasa Otake, Jiro Aoki, Gaku Nakazawa, Yohei Numasawa, Tatsuya Ito, Junya Shite, Takayuki Okamura, Kensuke Takagi, Kayoko Kozuma, Thierry Lefèvre, Bernard Chevalier, Yves Louvard, Nobuaki Suzuki, Ken Kozuma
    BACKGROUND: Clinical implications of proximal optimisation technique (POT) for bifurcation lesions have not been investigated in a randomised controlled trial. AIMS: This study aimed to investigate whether proximal optimisation technique (POT) is superior in terms of stent apposition compared with the conventional kissing balloon technique (KBT) in real-life bifurcation lesions using optical coherence tomography (OCT). METHODS: A total of 120 patients from 15 centres were randomised into two groups: POT followed by side branch dilation or KBT. Finally, 57 and 58 patients in the POT and KBT groups, respectively, were analysed. OCT was performed at baseline, immediately after wire recrossing to the side branch, and at the final procedure. RESULTS: The primary endpoint was the rate of malapposed struts assessed by the final OCT. The rate of malapposed struts did not differ between the POT and KBT groups (in-stent proximal site: 10.4% vs. 7.7%, p=0.33; bifurcation core: 1.4% vs. 1.1%, p=0.67; core's distal edge: 6.2% vs. 5.3%, p=0.59). More additional treatments were required among the POT group (40.4% vs. 6.9%, p<0.01). At 1-year follow-up, only one patient in each group underwent target lesion revascularisation (2.0% vs. 1.9%). CONCLUSIONS: POT followed by side branch dilation did not show any advantages over conventional KBT in terms of stent apposition, however, the excellent mid-term clinical outcomes were observed in both strategies.
    Mar. 2021, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 17(9) (9), 747 - 756, English, International magazine
    Scientific journal

  • PCIのための心筋虚血評価-冠血流予備能の測定に迫る- 心臓CT検査およびFFRCTに対する当院の取り組みについて
    鳥羽 敬義, 大竹 寛雅, 川森 裕之, 伊澤 有, 渡邊 慶明, 河野 淳, 根宜 典行, 平田 健一
    (一社)日本循環器学会, Mar. 2021, 日本循環器学会学術集会抄録集, 85回, CS3 - 4, Japanese

  • Kodai Komaki, Naofumi Yoshida, Seimi Satomi-Kobayashi, Yasunori Tsuboi, Masato Ogawa, Kumiko Wakida, Takayoshi Toba, Hiroyuki Kawamori, Hiromasa Otake, Atsushi Omura, Katsuhiro Yamanaka, Takeshi Inoue, Tomoya Yamashita, Yoshitada Sakai, Kazuhiro P Izawa, Kenji Okada, Ken-Ichi Hirata
    Assessment of frailty is important for risk stratification among the elderly with severe aortic stenosis (AS) when considering interventions such as surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). However, evidence of the impact of preoperative frailty on short-term postoperative outcomes or functional recovery is limited. This retrospective study included 234 consecutive patients with severe AS who underwent SAVR or TAVR at Kobe University Hospital between Dec 2013 and Dec 2019. Primary outcomes were postoperative complications, postoperative 6-min walking distance (6MWD), and home discharge rates. The mean age was 82 ± 6.6 years. There were 169 (SAVR: 80, TAVR: 89) and 65 (SAVR: 20, TAVR: 45) patients in the non-frail and frail groups, respectively (p = 0.02). The postoperative complication rates in the frail group were significantly higher than those in the non-frail group [30.8% (SAVR: 35.0%, TAVR: 28.9%) vs. 10.7% (SAVR: 15.0%, TAVR: 6.7%), p < 0.001]. The home discharge rate in the non-frail group was significantly higher than that in the frail group [85.2% (SAVR: 81.2%, TAVR: 88.8%) vs. 49.2% (SAVR: 55.0%, TAVR: 46.7%), p < 0.001]. The postoperative 6MWD in the non-frail group was significantly longer than that in the frail group [299.3 ± 87.8 m (SAVR: 321.9 ± 90.8 m, TAVR: 281.1 ± 81.3 m) vs. 141.9 ± 92.4 m (SAVR: 167.8 ± 92.5 m, TAVR: 131.6 ± 91.3 m), p < 0.001]. The TAVR group did not show a decrease in the 6MWD after intervention, regardless of frailty. We report for the first time that preoperative frailty was strongly associated with postoperative complications, 6MWD, and home discharge rates following both SAVR and TAVR. Preoperative frailty assessment may provide useful indications for planning better individualized therapeutic interventions and supporting comprehensive intensive care before and after interventions.
    Feb. 2021, Heart and vessels, 36(8) (8), 1234 - 1245, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiroyuki Yamamoto, Akihide Konishi, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Tsuyoshi Osue, Takahiro Sawada, Tomofumi Takaya, Hiroya Kawai, Naoko Hashimoto, Takeshi Ohara, Yushi Hirota, Kazuhiko Sakaguchi, Takashi Omori, Wataru Ogawa, Ken-Ichi Hirata
    BACKGROUND: The impact of reduction in glycemic excursion on coronary plaques remains unknown. This study aimed to elucidate whether a dipeptidyl peptidase 4 inhibitor could reduce the glycemic excursion and stabilize the coronary plaques compared with conventional management in coronary artery disease (CAD) patients with impaired glucose tolerance (IGT). METHODS: This was a multicenter, randomized controlled trial including CAD patients with IGT under lipid-lowering therapy receiving either vildagliptin (50 mg once a day) or no medication (control group) regarding glycemic treatment. The primary endpoint was changes in the minimum fibrous cap thickness and lipid arc in non-significant native coronary plaques detected by optical coherence tomography at 6 months after intervention. Glycemic variability expressed as the mean amplitude of glycemic excursion (MAGE) measured with a continuous glucose monitoring system was evaluated before and 6 months after intervention. RESULTS: A total of 20 participants with 47 lesions were allocated to either the vildagliptin group (10 participants, 22 lesions) or the control group (10 participants, 25 lesions). The adjusted difference of mean changes between the groups was - 18.8 mg/dl (95% confidence interval, - 30.8 to - 6.8) (p = 0.0064) for the MAGE (vildagliptin, - 20.1 ± 18.0 mg/dl vs. control, 2.6 ± 12.7 mg/dl), - 22.8° (- 40.6° to - 5.1°) (p = 0.0012) for the mean lipid arc (vildagliptin, - 9.0° ± 25.5° vs. control, 15.8° ± 16.8°), and 42.7 μm (15.3 to 70.1 μm) (p = 0.0022) for the minimum fibrous cap thickness (vildagliptin, 35.7 ± 50.8 μm vs. control, - 15.1 ± 25.2 μm). CONCLUSIONS: Vildagliptin could reduce the MAGE at 6 months and may be associated with the decreased lipid arc and increased minimum FCT of the coronary plaques in CAD patients with IGT as compared with the control group. These findings may represent its potential stabilization effect on coronary plaques, which are characteristic in this patient subset. Trial registration Registered in the UMIN clinical trial registry (UMIN000008620), Name of the registry: VOGUE trial, Date of registration: Aug 6, 2012, URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000010058.
    Feb. 2021, BMC cardiovascular disorders, 21(1) (1), 92 - 92, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Wataru Sasaki, Masaru Ishida, Tomonori Itoh, Yohei Uchimura, Hideto Oda, Yuya Taguchi, Kyosuke Kaneko, Tsubasa Sakamoto, Iwao Goto, Masafumi Sakuma, Daisuke Terashita, Hiromasa Otake, Toshiro Shinke, Yoshihiro Morino
    To compare early vascular healing following cobalt-chromium everolimus-eluting stent (CoCr-EES) implantation between groups with or without aggressive stent expansion in patients treated by CoCr-EES for stable coronary artery disease (CAD). Seventy-one stable CAD lesions underwent CoCr-EES implantation and analysis of serial optical coherence tomography (OCT) images obtained post-procedure and at early-term (1- or 3-month) follow-up. The endpoints of this study were neointimal thickness at the time of 1- or 3-month OCT and presence and healing of stent edge dissection. Aggressive stent expansion was defined as a lesion complying with ILUMIEN III sizing protocol; that is, external elastic lamina (EEL) diameter minus maximum balloon diameter ≤ 0.25 mm.  Comparing groups with and without aggressive stent expansion, median neointimal thickness at 1 and 3 months after CoCr-EES implantation was similar (1 month: 0.031 mm vs. 0.041 mm, respectively, p = 0.27; 3 months: 0.036 mm vs. 0.040 mm, respectively, p = 0.84). Regarding stent edge findings, the presence of any stent edge dissection immediately after percutaneous coronary intervention was also similar between the groups (25% vs. 15%, respectively; p = 0.30) and most stent edge dissections resolved completely within 3 months, regardless of location or dissection severity. After 1 year, no clinically driven target lesion revascularization or stent thrombosis was observed in either cohort. Even after aggressive stent expansion, early neointimal proliferation appeared modest with CoCr-EES implantation, and most stent edge dissections had resolved by 3 months. These findings may support the feasibility of EEL-based sizing by pre-stenting OCT.
    Feb. 2021, The international journal of cardiovascular imaging, 37(2) (2), 419 - 428, English, International magazine
    Scientific journal

  • Takayoshi Toba, Hiromasa Otake, Gilwoo Choi, Hyun Jin Kim, Hiroyuki Onishi, Yoichiro Sugizaki, Ryo Takeshige, Akira Nagasawa, Yuichiro Nagano, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Hiroyuki Kawamori, Shumpei Mori, Masahito Kawata, Charles A Taylor, Ken-Ichi Hirata
    Jan. 2021, JACC. Cardiovascular imaging, 14(1) (1), 315 - 317, English, International magazine

  • Takayoshi Toba, Shumpei Mori, Yu Izawa, Hiroyuki Toh, Daisuke Tsuda, Shinsuke Shimoyama, Hiroyuki Kawamori, Hiromasa Otake, Hidekazu Tanaka, Sei Fujiwara, Ken-Ichi Hirata
    BACKGROUND: Configurational changes in the proximal aorta are relevant to the procedural difficulty of transcatheter aortic valve implantation (TAVI). Among several morphological changes involving the ascending aorta, elongation is characteristics of elderly patients with aortic stenosis and can compromise the success and safety of TAVI. However, the effect of ascending aortic elongation on the overall morphology of the proximal aorta has not been established. AIMS: Our primary purpose was to investigate the effect of ascending aortic elongation on structural changes in the proximal aorta in TAVI candidates. MATERIALS & METHODS: In total, 121 consecutive patients with severe aortic stenosis (mean age, 84.5 ± 5.3 years; 69% women) who had undergone preprocedural computed tomography before TAVI were enrolled. We examined the structural anatomy of the proximal aorta in detail, focusing on its elongation, dilatation, tilting, rotation, and wedging. RESULTS: The mean length of the ascending aorta was 68.0 ± 9.2 mm, and the length was significantly correlated with dilatation (R = .278, p = .002), rightward tilting (R = .437, p < .001), clockwise rotation (R = .228, p = .018), and deep wedging (R = -.366, p < .001) of the proximal aorta. Elongation of the ascending aorta was correlated with dilatation, rightward tilting, clockwise rotation, and deep wedging of the proximal aorta in an elderly population with severe aortic stenosis. DISCUSSION: Appreciation of the clinical anatomy around the proximal aorta is required for clinicians involved in TAVI to estimate the procedural difficulty. CONCLUSION: Elongation of the ascending aorta was associated with dilatation, rightward tilting, clockwise rotation, and deep wedging of the proximal aorta.
    Nov. 2020, Clinical anatomy (New York, N.Y.), 33(8) (8), 1240 - 1248, English, International magazine
    Scientific journal

  • Masaru Ishida, Daisuke Terashita, Tomonori Itoh, Hiromasa Otake, Yoshiro Tsukiyama, Tatsuo Kikuchi, Takatoshi Hayashi, Takahide Suzuki, Yoshiaki Ito, Takashi Morita, Kiyoshi Hibi, Takahiro Sawada, Takayuki Okamura, Junya Shite, Fumiaki Takahashi, Toshiro Shinke, Yoshihiro Morino
    BACKGROUND: Second-generation drug-eluting stents (DES) reduce the incidence of stent thrombosis, even in patients with ST-segment elevated myocardial infarction (STEMI). However, the early local vascular healing after DES implantation in STEMI lesions, which mainly concerns stent thrombosis, is still unclear.Methods and Results:We attempted to determine early local vascular healing 3 months after cobalt-chromium everolimus-eluting stent (CoCr-EES) implantation in STEMI lesions relative to stable coronary artery disease (CAD) lesions. This prospective, multicenter study analyzed 96 total lesions (STEMI=49, stable CAD=51) by frequency domain-optical coherence tomography (FD-OCT) performed post-procedure and at the 3-month follow-up. Although CoCr-EES implanted in STEMI were almost entirely covered at 3 months, they had a relatively high incidence of uncovered struts compared with stable CAD (5.5% vs. 1.6%, P<0.001). Intrastent thrombus in the 2 groups was primarily resolved at the 3-month follow-up (STEMI: 91.7%→26.5%, stable CAD: 74.5%→11.8%). Regarding irregular protrusion, complete resolution was observed in stable CAD (21.6%→0%), while a few stents remained in STEMI (79.2%→8.2%). Although there were almost no changes for the serial change of average lumen area in STEMI, there were slight but significant decreases in stable CAD [STEMI 0.08 (-0.44, 0.55) mm2, stable CAD -0.35 (-0.55, 0.11) mm2; P=0.009]. CONCLUSIONS: Although strut coverage after CoCr-EES implantation for STEMI lesions was slightly delayed, the healing process appeared to be acceptable in both STEMI and stable CAD.
    Oct. 2020, Circulation journal : official journal of the Japanese Circulation Society, 84(11) (11), 1941 - 1948, English, Domestic magazine
    Scientific journal

  • Hiroyuki Kawamori, Akihide Konishi, Hiromasa Otake, Takayoshi Toba, Shinsuke Nakano, Kosuke Tanimura, Yoshiro Tsukiyama, Isao Nanba, Takashi Omori, Toshiro Shinke, Ken-ichi Hirata
    Intravascular optical coherence tomography is a high-resolution intracoronary imaging modality, providing a microscopic image of intravascular features. However, it has lower penetration depth than intravascular ultrasound. Recently, a second-generation optical frequency-domain imaging (OFDI) technique has been developed to provide greater penetration depth and faster pullback speed. However, there is little evidence supporting the efficacy of OFDI in patients with peripheral artery disease (PAD) undergoing endovascular treatment (EVT). We aimed to evaluate the ability of OFDI to visualize vessel walls from the superficial femoral artery (SFA) to the below-knee (BK) arteries, as well as the coronary arteries. This clinical trial is a single-center, single-arm, open-label study to be conducted in Japan. A total of 20 patients will be enrolled in this study. The primary endpoint is to obtain a clear image of the intravascular features of the SFA and BK arteries, specifically the visualization of ≥ 270° of the vessel lumen in ≥ 16 out of 21 cross sections. Obtaining clear images in ≥ 85% of cases will be regarded as confirmation of the ability of OFDI to visualize vessel walls from the SFA to the BK arteries. This is the first clinical trial to be conducted accordance with good clinical practice to expand the indications of OFDI for PAD patients undergoing EVT in Japan. The result of this study will help provide another imaging option during EVT in daily practice.
    Oct. 2020, Cardiovascular intervention and therapeutics, 35(4) (4), 385 - 391, English, Domestic magazine
    Scientific journal

  • Hiroyuki Kawamori, Akihide Konishi, Hiromasa Otake, Takayoshi Toba, Shinsuke Nakano, Kosuke Tanimura, Yoshiro Tsukiyama, Isao Nanba, Takashi Omori, Toshiro Shinke, Ken-Ichi Hirata
    In the original publication of the article, the author group was published without full names and one of the co-authors' name was published incorrectly. The full names of author group and correct co-authors' name are given in this Correction.
    Oct. 2020, Cardiovascular intervention and therapeutics, 35(4) (4), 392 - 392, English, Domestic magazine
    Scientific journal

  • Kazunori Horie, Shoichi Kuramitsu, Tomohiro Shinozaki, Masanobu Ohya, Hiromasa Otake, Futoshi Yamanaka, Hiroki Shiomi, Masahiro Natsuaki, Gaku Nakazawa, Norio Tada, Kenji Ando, Kazushige Kadota, Shigeru Saito, Takeshi Kimura
    Limited data exist on the comparison of clinical outcomes after first- and second-generation drug-eluting stent (DES) thrombosis. From the Retrospective Multicenter Registry of Stent Thrombosis (ST) After First- and Second-Generation DES Implantation registry, this study evaluated 655 ST patients (first-generation DES thrombosis [G1-ST], n = 342; second-generation DES thrombosis [G2-ST], n = 313). After propensity score matching, the final study population consisted of 159 matched patients. The primary end point was the cumulative 1-year incidence of mortality. The mortality after G2-ST at 1 year was similar to that after G1-ST (23.0% vs 22.9%, p = 0.76). Also, the G2-ST group showed a significantly lower rate of target lesion revascularization than the G1-ST group (9.7% vs 17.1%, p = 0.01). Risk factors of 1-year mortality included cardiogenic shock or arrest at the time of ST, multivessel ST, left ventricular ejection fraction ≤40%, advanced age, and final thrombolysis in myocardial infarction flow grade ≤2. In conclusion, patients with G2-ST showed a similar 1-year mortality to those with G1-ST, highlighting that ST remains a life-threatening complication in the second-generation DES era.
    Oct. 2020, The American journal of cardiology, 132, 52 - 58, English, International magazine
    Scientific journal

  • Tomoyo Hamana, Masamichi Iwasaki, Hiromasa Otake, Tatsuya Kokawa, Yuta Fukuishi, Susumu Odajima, Wataru Fujimoto, Koji Kuroda, Yutaka Hatani, Takumi Inoue, Hiroshi Okamoto, Masanori Okuda, Takatoshi Hayashi
    A sigmoid septum is a state of angulation between the basal interventricular septum and the ascending aorta. Although considered to have no clinical importance, it may cause left ventricular outflow tract obstruction (LVOTO) in a hypercontractile state. Percutaneous transluminal septal myocardial ablation (PTSMA) is a catheter-based therapy aimed at improving drug-refractory symptoms in patients with hypertrophic obstructive cardiomyopathy. Few studies have reported the use of PTSMA for patients with LVOTO caused by sigmoid septum. We present a successful case of a 71-year-old female patient who presented with a long history of exertional dyspnea. The presence of a sigmoid septum was revealed on echocardiography. At rest, the left ventricular outflow tract pressure gradient was low and there were no signs of systolic anterior motion (SAM) of the mitral valve; however, during Valsalva maneuver, the gradient increased significantly, and SAM could be seen. We successfully performed PTSMA, resulting in a significant lowering of the pressure gradient and disappearance of SAM. The patient's symptoms dramatically improved by the following day. .
    Oct. 2020, Journal of cardiology cases, 22(4) (4), 159 - 162, English, Domestic magazine

  • Yoichiro Sugizaki, Hiromasa Otake, Koji Kuroda, Hiroyuki Kawamori, Takayoshi Toba, Akira Nagasawa, Ryo Takeshige, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Ken-Ichi Hirata
    BACKGROUND: In-stent neoatherosclerosis (NA) is a risk for future cardiovascular events through atherosclerotic progression in non-stented lesions. Using optical coherence tomography, this study assessed the efficacy of intensive therapy with 10 mg/day rosuvastatin plus 1,800 mg/day eicosapentaenoic acid (EPA) vs. standard 2.5 mg/day rosuvastatin therapy on native coronary plaques in patients with NA.Methods and Results:This was a subgroup analysis of the randomized LINK-IT trial, which was designed to compare changes in the lipid index in NA between intensive and standard therapy for 12 months. In all, 42 patients with native coronary plaques and NA were assessed. Compared with standard therapy, intensive therapy resulted in greater decreases in serum low-density lipoprotein cholesterol concentrations and greater increases in serum 18-hydroxyeicosapentaenoic acid concentrations, with significantly greater decreases in the lipid index and macrophage grade in both NA (-24 vs. 217 [P<0.001] and -15 vs. 24 [P<0.001], respectively) and native coronary plaques (-112 vs. 29 [P<0.001] and -17 vs. 1 [P<0.001], respectively) following intensive therapy. Although there was a greater increase in the macrophage grade in NA than in native coronary plaques in the standard therapy group, in the intensive therapy group there were comparable reductions in macrophage grade between NA and native coronary plaques. CONCLUSIONS: Compared with standard therapy, intensive therapy prevented atherosclerotic progression more effectively in native coronary plaques in patients with NA.
    Sep. 2020, Circulation journal : official journal of the Japanese Circulation Society, 84(10) (10), 1826 - 1836, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiromasa Otake, Takashi Kubo, Toshiro Shinke, Kiyoshi Hibi, Shigemitsu Tanaka, Masaru Ishida, Toru Kataoka, Tomofumi Takaya, Masamichi Iwasaki, Shinjo Sonoda, Tetsuya Ioji, Takashi Akasaka
    BACKGROUND: A recent clinical trial demonstrated that optical frequency domain imaging (OFDI) guidance in percutaneous coronary intervention (PCI) is noninferior to intravascular ultrasound (IVUS) guidance in patients with coronary artery disease with regard to target vessel failure (composed of cardiac death, myocardial infarction attributed to the target vessel, and clinically-driven target vessel revascularization) at 12 months. The impact of OFDI guidance in PCI for patients with acute coronary syndrome (ACS) remains uncertain. METHODS: OPINION ACS is a multicenter, prospective, randomized, controlled, open-label, parallel group, non-inferiority trial in Japan. Eligible patients will be randomly assigned to receive either OFDI- or IVUS-guided PCI. PCI is performed using the sirolimus-eluting stent in accordance with certain OFDI and IVUS criteria for optimal stent deployment. All patients will undergo follow-up angiography and OFDI imaging at 8 months. The primary endpoint is the minimum lumen area, as measured by OFDI at 8 months. CONCLUSION: The OPINION ACS trial outcomes will provide insights regarding the impact of OFDI-guided PCI on in-stent restenosis at 8 months in patients with ACS.
    Sep. 2020, Journal of cardiology, 76(3) (3), 317 - 321, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yoshiro Tsukiyama, Akihide Konishi, Toshiro Shinke, Amane Kozuki, Hiromasa Otake, Hiroyuki Kawamori, Kenichi Yanaka, Osamu Iida, Takayuki Ishihara, Takumi Inoue, Masamichi Iwasaki, Makoto Kadotani, Naoki Matsukawa, Keiji Noutomi, Yasumasa Kakei, Isao Nanba, Takashi Omori, Junya Shite, Ken-Ichi Hirata
    Although balloon angioplasty for femoropopliteal artery lesions has been associated with restenosis rates of up to 60% at 12 months, the mechanism of restenosis has not been fully evaluated. The aim of this study was to evaluate the relationship between the vascular features observed on optical frequency domain imaging (OFDI) before and after balloon angioplasty of femoropopliteal artery lesions, and restenosis at 6 months. This study was a prospective multicenter single arm study. OFDI was performed before and after balloon angioplasty and plaque characteristics and vascular features, along with de novo lesions, were assessed. The primary outcome was the presence or absence of restenosis 6 months after balloon angioplasty. Residual platelet reactivity was assessed according to VerifyNow platelet reactivity units (PRUs). The number of patients completing 6 months of follow-up was 47, of which 14 had developed restenosis. Maximum thickness of the dissection flap (odds ratio (OR) 2.71; 95% confidence interval [0.9-8.0]; p = 0.071) and lesion length were identified as risk factors for restenosis (OR 1.015; 95% confidence interval [0.001-0.029]; p = 0.039). The mean PRU at the time of treatment in patients with restenosis was significantly higher than in those without restenosis (286.3 ± 82.6 vs. 208.5 ± 03.6, p = 0.026). Long lesions and major dissection on OFDI after balloon angioplasty for femoropopliteal artery lesions increase restenosis at 6 months. In addition, high residual platelet reactivity at the time of EVT may also be a risk factor for restenosis.Clinical Trial Registration Number UMIN000021120.
    Jun. 2020, Cardiovascular intervention and therapeutics, 36(3) (3), 321 - 329, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Hitoshi Matsuo, Tomohiro Kawasaki, Tetsuya Amano, Yoshiaki Kawase, Yoshihiro Sobue, Takeshi Kondo, Yoshihiro Morino, Shunichi Yoda, Tomohiro Sakamoto, Hiroshi Ito, Junya Shite, Hiromasa Otake, Nobuhiro Tanaka, Mitsuyasu Terashima, Kazushige Kadota, Manesh R Patel, Koen Nieman, Campbell Rogers, Bjarne L Norgaard, Jeroen J Bax, Kavitha M Chinnaiyan, Daniel S Berman, Timothy A Fairbairn, Lynne M Hurwitz Koweek, Jonathon Leipsic, Takashi Akasaka
    Background: Coronary computed tomography angiography (CCTA)-derived fractional flow reserve (FFRCT) is an established tool for identifying lesion-specific ischemia that is now approved for use by the Japanese insurance system. However, current clinical reimbursement is strictly limited to institutions with designated appropriate use criteria (AUC). This study assessed differences in physicians' behavior (e.g., use and interpretation of FFRCT, final management) according to Japanese AUC and non-AUC site designation. Methods and Results: Of 5,083 patients in the ADVANCE Registry, 1,829 from Japan were enrolled in this study. Physicians' behavior after interrogating CCTA and FFRCT was analyzed separately according to AUC and non-AUC site designation. Compared with AUC sites, patients referred for FFRCT from non-AUC sites had a higher rate of negative FFRCT, less severe anatomic stenosis, and a slightly lower rate of management plan reclassification (51.2% vs. 61.3%), with near-identical utility in both groups. Actual care corresponded equally well to post-FFRCT plans in both groups. The likelihood of revascularization for positive or negative FFRCT was similar between the 2 groups. Importantly, AUC and non-AUC sites were equally unlikely to revascularize patients with negative FFRCT and stenosis >50% or patients with positive FFRCT and stenosis <50%. Conclusions: Compared with AUC sites, non-AUC sites had lower disease burden and reclassification of management plans, but nearly identical clinical integration. Actual care corresponded equally well to post-FFRCT recommendations at both sites.
    Jun. 2020, Circulation reports, 2(7) (7), 364 - 371, English, Domestic magazine
    Scientific journal

  • Hideto Oda, Tomonori Itoh, Wataru Sasaki, Yohei Uchimura, Yuya Taguchi, Kyosuke Kaneko, Tsubasa Sakamoto, Iwao Goto, Masafumi Sakuma, Masaru Ishida, Tatsuo Kikuchi, Daisuke Terashita, Hiromasa Otake, Yoshihiro Morino, Toshiro Shinke
    OBJECTIVE: The purpose of this study was to identify a cut-off value to predict the resolution of incomplete-stent-apposition (ISA) after cobalt-chromium everolimus-eluting stent (CoCr-EES) implantation at early follow-up. BACKGROUND: To date, appropriate stent apposition at the acute period using intracoronary imaging has been recommended because persistent ISA is considered to be a risk factor for stent thrombosis. We examined the indices for resolving acute ISA. In particular, we determined the cut-off value for strut vessel distance (SV-distance) as visualized by optical coherence tomography (OCT) at 8 months after CoCr-EES implantation. However, the cut-off value of SV-distance for the earlier resolution of ISA is unclear. METHODS: A total of 95 cases and 103 stents were registered in the MECHANISM Elective substudy. The SV-distance was measured at the deepest site of the target malapposition and every 1 mm from the proximal edge to the distal edge of the mal-apposed area using OCT. Cut-off values for ISA resolution at 1 and 3 months were estimated by SV-distance using receiver operating characteristic analysis. RESULTS: The total number of analyzed struts was 14,418 at the 1-month follow-up and 11,986 at the 3-month follow-up. The optimal SV-distance cut-off values just after stent implantation to predict ISA resolution were 185 µm at the 1-month follow-up and 195 μm at the 3-month follow-up. CONCLUSION: For resolution of ISA, SV-distance cut-off values of 185 µm at 1 month postimplantation and 195 μm at 3 months postimplantation can be used as the index of endpoint of the percutaneous coronary intervention.
    Jun. 2020, Journal of cardiology, 75(6) (6), 641 - 647, English, International magazine
    Scientific journal

  • Yoichiro Sugizaki, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-Ichi Yanaka, Hiroyuki Yamamoto, Akira Nagasawa, Hiroyuki Onishi, Ryo Takeshige, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Toshiro Shinke, Tatsuro Ishida, Ken-Ichi Hirata
    Jun. 2020, JACC. Cardiovascular imaging, 13(6) (6), 1452 - 1454, English, International magazine

  • Makiko Suzuki, Kensuke Matsumoto, Makiko Suto, Yayoi Taniguchi, Hidekazu Tanaka, Hiromasa Otake, Toshiro Shinke, Ken-Ichi Hirata
    A 92-year-old man was referred to our hospital with decompensated heart failure. He was treated with diuretics and inotropic agents, but the clinical response was unsatisfactory. Echocardiography incidentally revealed an atrial septal defect (ASD) with a significant left-to-right shunt and pulmonary-to-systemic-blood-flow ratio of 2.36. Because the ASD was considered to be the primary cause of his treatment-resistant heart failure, the patient underwent transcatheter ASD closure. Shortly after shunt closure, his hemodynamics significantly improved, and he was discharged nine days later. This is an extremely rare case of a nonagenarian who showed an excellent clinical course after transcatheter ASD closure.
    Apr. 2020, Internal medicine (Tokyo, Japan), 59(8) (8), 1059 - 1063, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Toshihiko Oshita, Ryuji Toh, Yuichiro Nagano, Koji Kuroda, Yoshinori Nagasawa, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Takuya Kubo, Takuya Iino, Manabu Nagao, Yasuhiro Irino, Tetsuya Hara, Masakazu Shinohara, Hiromasa Otake, Toshiro Shinke, Katsuyuki Nakajima, Tatsuro Ishida, Ken-Ichi Hirata
    BACKGROUND: Cholesterol efflux from atherosclerotic lesion is a key function of high-density lipoprotein (HDL). Recently, we established a simple, high-throughput, cell-free assay to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as "cholesterol uptake capacity (CUC)". OBJECTIVE: To clarify the cross-sectional relationship between CUC and coronary plaque properties. METHODS: We enrolled 135 patients to measure CUC and assess the morphological features of angiographic stenosis by optical coherence tomography (OCT). We estimated the extent of the lipid-rich plaque by multiplying the mean lipid arc by lipid length (lipid index). The extent of the OCT-detected macrophage accumulation in the target plaque was semi-quantitatively estimated using a grading system. RESULTS: Lipid-rich plaque lesions were identified in 125 patients (92.6%). CUC was inversely associated with the lipid index (R = -0.348, P < 0.0001). In addition, CUC was also inversely associated with macrophage score (R = -0.327, P < 0.0001). Conversely, neither circulating levels of HDL cholesterol nor apoA1 showed a similar relationship. CONCLUSIONS: We demonstrated that CUC was inversely related to lipid-rich plaque burden and the extent of macrophage accumulation, suggesting that CUC could be useful for cardiovascular risk stratification.
    Apr. 2020, Clinica chimica acta; international journal of clinical chemistry, 503, 136 - 144, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yusuke Watanabe, Kenichi Sakakura, Hideo Fujita, Masanobu Ohya, Kazunori Horie, Futoshi Yamanaka, Gaku Nakazawa, Hiromasa Otake, Hiroki Shiomi, Masahiro Natsuaki, Kenji Ando, Kazushige Kadota, Shigeru Saito, Takeshi Kimura, Shoichi Kuramitsu
    BACKGROUND: Stent thrombosis (ST) remains a severe complication following stent implantation. We previously reported the risk factors for ST after 2nd-generation drug-eluting stent (DES) in the REAL-ST (Retrospective Multicenter Registry of ST After First- and Second-Generation DES Implantation) registry.Methods and Results:In this subanalysis, we aimed to reveal the difference in ST between right coronary (RCA) and left (LCA) coronary arteries. A total of 307 patients with ST were divided into the RCA-ST group (n=93) and the LCA-ST group (n=214). Multivariate analysis revealed younger age (odds ratio [OR] 0.96, 95% confidence interval [CI] 0.93-0.99, P=0.01), ostial lesion at the time of index percutaneous coronary intervention (OR 4.37, 95% CI 1.43-13.33, P=0.01), bifurcation lesion at the time of index PCI (OR 0.05, 95% CI 0.02-0.12, P<0.01), chronic total occlusion (CTO) lesion at the time of index PCI indication (OR 4.19, 95% CI 1.05-16.71, P=0.04), and use of prasugrel at the time of ST (OR 7.30, 95% CI 1.44-36.97, P=0.02) were significantly associated with RCA-ST. CONCLUSIONS: Younger age, ostial or CTO lesion, and use of prasugrel at the time of ST were prominent factors in RCA-ST, whereas bifurcation lesion was associated with LCA-ST. We should pay attention to the differences between RCA-ST and LCA-ST to prevent ST.
    Jan. 2020, Circulation journal : official journal of the Japanese Circulation Society, 84(2) (2), 169 - 177, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Kenichi Fujii, Takashi Kubo, Hiromasa Otake, Gaku Nakazawa, Shinjo Sonoda, Kiyoshi Hibi, Toshiro Shinke, Yoshio Kobayashi, Yuji Ikari, Takashi Akasaka
    In this document, the methods for the quantitative measurement and morphological assessment of optical coherence tomography (OCT)/optical frequency domain imaging images (OFDI) are briefly summarized. The focus is on the clinical application of OCT/OFDI to guide percutaneous coronary interventions.
    Jan. 2020, Cardiovascular intervention and therapeutics, 35(1) (1), 13 - 18, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Koji Kuroda, Hiromasa Otake, Masakazu Shinohara, Masaru Kuroda, Shigeyasu Tsuda, Takayoshi Toba, Yuichiro Nagano, Ryuji Toh, Tatsuro Ishida, Toshiro Shinke, Ken-Ichi Hirata
    AIMS: We aimed to assess the effect of 10 mg/day of rosuvastatin plus eicosapentaenoic acid (EPA) versus 2.5 mg/day of rosuvastatin on the extent of neoatherosclerosis using optical coherence tomography (OCT). METHODS AND RESULTS: We randomly assigned 50 patients with non-obstructive neoatherosclerotic plaques detected on OCT to receive either rosuvastatin 10 mg/day and EPA 1,800 mg/day (intensive therapy group) or rosuvastatin 2.5 mg (standard therapy group). Follow-up OCT was performed one year later to evaluate serial changes in neoatherosclerosis. The serum low-density lipoprotein cholesterol (LDL-C) level decreased significantly from baseline to 12-month follow-up in the intensive therapy group (89 mg/dL to 70 mg/dL; p<0.001), while no change occurred in the standard therapy group. Lipid index change and percent changes in macrophage grade were significantly lower in the intensive therapy group than in the standard therapy group (-53.6 vs 310.1, p=0.001; -37.0% vs 35.3%, p<0.001; respectively). Percent changes in lipid index and macrophage grade were positively correlated with the changes in serum LDL-C and C-reactive protein levels, and negatively correlated with the change in serum EPA/arachidonic acid and 18-hydroxyeicosapentaenoic acid (EPA bioactive metabolite) level. CONCLUSIONS: Compared with rosuvastatin 2.5 mg/day, rosuvastatin 10 mg/day and EPA 1,800 mg/day significantly stabilised non-obstructive neoatherosclerotic plaques. CLINICAL TRIAL REGISTRATION: UMIN ID: UMIN000012576. https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000014711.
    Dec. 2019, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 15(12) (12), e1099-e1106, English, International magazine
    [Refereed]
    Scientific journal

  • Jiesuck Park, Joo Myung Lee, Bon-Kwon Koo, Gilwoo Choi, Doyeon Hwang, Tae-Min Rhee, Seokhun Yang, Jonghanne Park, Jinlong Zhang, Kyung-Jin Kim, Yaliang Tong, Joon-Hyung Doh, Chang-Wook Nam, Eun-Seok Shin, Young-Seok Cho, Eun Ju Chun, Jin-Ho Choi, Bjarne L Norgaard, Evald H Christiansen, Koen Niemen, Hiromasa Otake, Martin Penicka, Bernard de Bruyne, Takashi Kubo, Takashi Akasaka, Jagat Narula, Pamela S Douglas, Charles A Taylor
    OBJECTIVES: We explored the anatomical, plaque, and hemodynamic characteristics of high-risk non-obstructive coronary lesions that caused acute coronary syndrome (ACS). METHODS: From the EMERALD study which included ACS patients with available coronary CT angiography (CCTA) before the ACS, non-obstructive lesions (percent diameter stenosis < 50%) were selected. CCTA images were analyzed for lesion characteristics by independent CCTA and computational fluid dynamics core laboratories. The relative importance of each characteristic was assessed by information gain. RESULTS: Of the 132 lesions, 24 were the culprit for ACS. The culprit lesions showed a larger change in FFRCT across the lesion (ΔFFRCT) than non-culprit lesions (0.08 ± 0.07 vs 0.05 ± 0.05, p = 0.012). ΔFFRCT showed the highest information gain (0.051, 95% confidence interval [CI] 0.050-0.052), followed by low-attenuation plaque (0.028, 95% CI 0.027-0.029) and plaque volume (0.023, 95% CI 0.022-0.024). Lesions with higher ΔFFRCT or low-attenuation plaque showed an increased risk of ACS (hazard ratio [HR] 3.25, 95% CI 1.31-8.04, p = 0.010 for ΔFFRCT; HR 2.60, 95% CI 1.36-4.95, p = 0.004 for low-attenuation plaque). The prediction model including ΔFFRCT, low-attenuation plaque and plaque volume showed the highest ability in ACS prediction (AUC 0.725, 95% CI 0.724-0.727). CONCLUSION: Non-obstructive lesions with higher ΔFFRCT or low-attenuation plaque showed a higher risk of ACS. The integration of anatomical, plaque, and hemodynamic characteristics can improve the noninvasive prediction of ACS risk in non-obstructive lesions. KEY POINTS: • Change in FFR CT across the lesion (ΔFFR CT ) was the most important predictor of ACS risk in non-obstructive lesions. • Non-obstructive lesions with higher ΔFFR CT or low-attenuation plaque were associated with a higher risk of ACS. • The integration of anatomical, plaque, and hemodynamic characteristics can improve the noninvasive prediction of ACS risk.
    Nov. 2019, European radiology, 29(11) (11), 6119 - 6128, English, International magazine
    Scientific journal

  • Yohei Uchimura, Tomonori Itoh, Hideto Oda, Yuya Taguchi, Wataru Sasaki, Kyosuke Kaneko, Tsubasa Sakamoto, Iwao Goto, Masafumi Sakuma, Masaru Ishida, Tatsuo Kikuchi, Daisuke Terashita, Hiromasa Otake, Yoshihiro Morino, Toshiro Shinke
    The purpose of this study was to clarify a cut-off value for acute incomplete stent apposition (ISA) volume and maximum-depth to predict ISA resolution at 1- and 3-month follow-up in patients treated with cobalt-chromium everolimus-eluting stents. In total, 95 cases and 103 stents were registered in the MECHANISM-Elective sub-study. Acute ISA-volume was measured by the trapezoid rule. ISA resolution of cut-off value at 1- and 3-month was estimated by ISA-volume and maximum-depth using receiver operatorating characteristic curve analysis. The total number of analysed acute ISAs was 202 in the 1-month group and 225 in the 3-month group. A total of 123 ISAs at 1-month and a total of 169 ISAs at 3-month had been resolved. The cut-off value of ISA resolution by ISA-volume was 0.169 mm3 at 1-month (AUC: 0.725, sensitivity: 72.2%, specificity: 61.0%) and 0.295 mm3 at 3-month (AUC: 0.757, sensitivity: 75.0%, specificity: 60.4%). The cut-off value of ISA resolution by ISA maximum-depth demonstrated was 0.285 mm at 1-month (area under curve (AUC): 0.789, sensitivity: 70.9%, specificity: 69.9%) and 0.305 mm at 3-month (AUC: 0.663, sensitivity: 60.7%, specificity: 66.9%). Incidence of ISA resolution was significantly lower in combination with cut-off values of ISA-volume and maximum-depth (33%, p < 0.001, at 1-month; 56%, p = 0.003, at 3-month). Combining the cut-off value of ISA-volume with the maximum-depth might be helpful to consider the endpoint of the PCI procedure.
    Nov. 2019, The international journal of cardiovascular imaging, 35(11) (11), 1979 - 1987, English, International magazine
    Scientific journal

  • Toshiro Shinke, Tomonori Itoh, Masaru Ishida, Hiromasa Otake, Daisuke Terashita, Tetsuya Fusazaki, Tatsuo Kikuchi, Takayuki Okamura, Takashi Morita, Takatoshi Hayashi, Takahiro Sawada, Yoshinori Yasaka, Takumi Inoue, Akira Matsuura, Masahito Kawata, Amane Kozuki, Junya Shite, Toru Kataoka, Kiyoshi Hibi, Shozo Ishihara, Takashi Akasaka, Takashi Kubo, Yasushi Ino, Shinjo Sonoda, Jungo Furuya, Teppei Sugaya, Yoshisato Shibata, Nehiro Kuriyama, Nobuaki Igarashi, Daisuke Matsumoto, Noritoshi Hiranuma, Yoritaka Otsuka, Yoshihiro Morino
    BACKGROUND: Analysis of pooled clinical data has shown the safety of 3 months of dual antiplatelet therapy with everolimus-eluting cobalt-chromium stents (Co-Cr EESs). This study evaluated early and mid-term vascular responses to Co-Cr EESs in patients with stable coronary artery disease. METHODS: The Multicenter Comparison of Early and Late Vascular Responses to Everolimus-Eluting Cobalt-Chromium Stent and Platelet Aggregation Studies in Patients With Stable Angina Managed as Elective Case (MECHANISM-Elective) study (NCT02014818) is a multicenter optical coherence tomography (OCT) registry. Enrolled patients were evaluated by OCT immediately after everolimus-eluting stent implantation were prospectively allocated to 1 month (n = 50) or 3 months (n = 50) OCT follow-up and then received a 12-month OCT evaluation. The incidences of intrastent thrombus (IS-Th) and irregular protrusion (IRP) were also assessed. RESULTS: The percentage of uncovered struts was 6.4% ± 10.3% at 1 month (P < 0.001 vs. postprocedure) and 0.5% ± 0.9% at 12 months (P < 0.001 vs. 1 month). The corresponding values in the 3-month cohort were 2.0% ± 2.5% (P < 0.001 vs. postprocedure) and 0.5% ± 1.5% (P < 0.001 vs. 3 months). The incidence of IS-Th was 32.7% at 1 month, 5.4% at 3 months, and 2.0% at 12 months. IRP was observed in 21.8% of patients post-EES but had totally resolved at 1, 3, and 12 months. CONCLUSION: Early and mid-term vascular reactions after Co-Cr EES implantation in stable patients with coronary artery disease in the MECHANISM-Elective included dynamic resolution of IS-Th and IRP and rapid decrease in uncovered struts. Thus, EES may allow shortening of dual antiplatelet therapy duration less than 3 months in this patient subset.
    Nov. 2019, The Canadian journal of cardiology, 35(11) (11), 1513 - 1522, English, International magazine
    [Refereed]
    Scientific journal

  • Yoshiro Tsukiyama, Toshiro Shinke, Takayuki Ishihara, Hiromasa Otake, Daisuke Terashita, Amane Kozuki, Masashi Fukunaga, Kan Zen, Tetsuo Horimatsu, Kenichi Fujii, Junya Shite, Masaaki Uematsu, Mitsuyoshi Takahara, Osamu Iida, Shinsuke Nanto, Ken-Ichi Hirata
    The aim of this study was to elucidate the vascular responses to paclitaxel-eluting stent (Zilver PTX stent) in superficial femoral artery lesion at different elapsed times using angioscopy. Patients who received Zilver PTX stent implantation from five centers were enrolled. We performed angioscopic examinations at 2, 6, and 12 months after implantation and evaluated neointimal coverage (NIC) grade, intra-stent thrombus (IS-Th) grade, and presence of yellow plaque. NIC grade 0 was defined as stent struts exposed; grade 1, struts transparently visible although covered; grade 2, struts embedded in the neointima, but translucent; and grade 3, struts fully embedded and invisible. IS-Th was graded as follows: grade 0 (none), 1 (focal), and 2 (diffusely spread). Angioscopic follow-up evaluation was performed at 2 months (25 patients, 42 lesions), 6 months (18 patients, 23 stents), and 12 months (14 patients, 24 stents) after stent implantation. Dominant NIC grade significantly increased over time; however, 16.3% of the cases had NIC grade 1 or 2 at 12 months. IS-Th grade decreased; however IS-Th and yellow plaque were persistently observed in 62.5% and 83.3% cases, respectively, at 12 months. An ongoing healing response was observed at 12 months after implantation; however, thrombogenic findings were noted. Prolonged dual antiplatelet therapy could potentially enhance the clinical utility of Zilver PTX.
    Oct. 2019, The international journal of cardiovascular imaging, 35(10) (10), 1777 - 1784, English, International magazine
    Scientific journal

  • Junya Ako, Kiyoshi Hibi, Kenichi Tsujita, Takafumi Hiro, Yoshihiro Morino, Ken Kozuma, Toshiro Shinke, Hiromasa Otake, Kiyoko Uno, Michael J Louie, Yoshiharu Takagi, Katsumi Miyauchi
    Sep. 2019, Circulation journal : official journal of the Japanese Circulation Society, 83(10) (10), 2025 - 2033, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Ruptured plaqueとNon-Ruptured plaqueによるST上昇型心筋梗塞に対するPCI後の血管治癒反応の違いについての検討
    菊池 達郎, 寺下 大輔, 大竹 寛雅, 新家 俊郎, 鈴木 孝英, 伊藤 良明, 栗山 根廣, 林 孝俊, 日比 潔, 田中 博之, 伊藤 智範, 森野 禎浩
    (一社)日本心血管インターベンション治療学会, Sep. 2019, 日本心血管インターベンション治療学会抄録集, 28回, [MO11 - 004], English

  • Shoichi Kuramitsu, Masanobu Ohya, Tomohiro Shinozaki, Hiromasa Otake, Kazunori Horie, Hiroyoshi Kawamoto, Futoshi Yamanaka, Masahiro Natsuaki, Hiroki Shiomi, Gaku Nakazawa, Kenji Ando, Kazushige Kadota, Shigeru Saito, Takeshi Kimura
    Background The risk factors and long-term clinical outcomes of patients with definite stent thrombosis (ST) after second-generation drug-eluting stent (DES) implantation have not yet been adequately assessed. Methods and Results The REAL-ST (Retrospective Multicenter Registry of ST After First- and Second-Generation DES Implantation) included 313 definite ST of second-generation DES (early ST, n=179; late ST, n=66; very late ST, n=68). Four patients without definite ST of second-generation DES were identified as control patients for each ST case. Risk factors of definite ST were mostly different according to the timing of ST: ST-segment-elevation myocardial infarction, non-ST-segment-elevation myocardial infarction, and unstable angina at presentation, current smoking, left ventricular ejection fraction <40%, prior percutaneous coronary intervention, stent overlap, severely calcified lesion, left main coronary artery lesion, proximal left anterior descending lesion, postdiameter stenosis ≥20%, for early ST; age <70 years, ST-segment-elevation myocardial infarction at presentation, hemodialysis, left ventricular ejection fraction <40%, in-stent restenosis, and severely calcified lesion for late ST; and proximal left anterior descending lesion and in-stent restenosis for very late ST. Cumulative 4-year incidence of death after the index ST events was significantly higher in the ST patients than control patients (33.0% versus 12.3%, P<0.001 for early ST versus control; 30.6% versus 14.2%, P<0.001 for late ST versus control; and 28.0% versus 13.0%, P<0.001 for very late ST versus control, respectively). Conclusions Risk factors of definite ST after second-generation DES implantation were mostly different according to the timing of ST. Definite ST patients showed unfavorable long-term clinical outcomes compared with those without definite ST. Clinical Trial Registration URL: https://www.umin.ac.jp . Unique identifier: UMIN000025181.
    Jun. 2019, Circulation. Cardiovascular interventions, 12(6) (6), e007822, English, International magazine
    Scientific journal

  • Yasutsugu Shiono, Hitoshi Matsuo, Tomohiro Kawasaki, Tetsuya Amano, Hironori Kitabata, Takashi Kubo, Yoshihiro Morino, Shunichi Yoda, Tomohiro Sakamoto, Hiroshi Ito, Junya Shite, Hiromasa Otake, Nobuhiro Tanaka, Mitsuyasu Terashima, Kazushige Kadota, Manesh R Patel, Koen Nieman, Campbell Rogers, Bjarne L Nørgaard, Jeroen J Bax, Gilbert L Raff, Kavitha M Chinnaiyan, Daniel S Berman, Timothy A Fairbairn, Lynne M Hurwitz Koweek, Jonathon Leipsic, Takashi Akasaka
    BACKGROUND: Coronary computed tomography angiography (cCTA)-derived fractional flow reserve (FFRCT) is a promising diagnostic method for the evaluation of coronary artery disease (CAD). However, clinical data regarding FFRCTin Japan are scarce, so we assessed the clinical impact of using FFRCTin a Japanese population.Methods and Results:The ADVANCE registry is an international prospective FFRCTregistry of patients suspected of CAD. Of 5,083 patients, 1,829 subjects enrolled from Japan were analyzed. Demographics, symptoms, cCTA, FFRCT, treatment strategy, and 90-day major cardiovascular events (MACE) were assessed. Reclassification of treatment strategy between cCTA alone and cCTA+FFRCToccurred in 55.8% of site investigations and in 56.9% in the core laboratory analysis. Patients with positive FFR (FFRCT≤0.80) were less likely to have non-obstructive disease on invasive coronary angiography than patients with negative FFR (FFRCT>0.80) (20.5% vs. 46.1%, P=0.0001). After FFRCT, 67.0% of patients with positive results underwent revascularization, whereas 96.1% of patients with negative FFRCTwere medically treated. MACE occurred in 5 patients with positive FFRCT, but none occurred in patients with negative FFRCTwithin 90 days. CONCLUSIONS: In this Japanese population, FFRCTmodified the treatment strategy in more than half of the patients. FFRCTshowed potential for stratifying patients suspected of CAD properly into invasive or non-invasive management pathways.
    May 2019, Circulation journal : official journal of the Japanese Circulation Society, 83(6) (6), 1293 - 1301, English, Domestic magazine
    Scientific journal

  • Yuichiro Nagano, Hiromasa Otake, Takayoshi Toba, Koji Kuroda, Yuto Shinkura, Natsuko Tahara, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Akira Nagasawa, Hiroyuki Onishi, Yoichiro Sugizaki, Ryo Takeshige, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Toshihiko Oshita, Yasuhiro Irino, Hiroyuki Kawamori, Tatsuro Ishida, Ryuji Toh, Toshiro Shinke, Ken-Ichi Hirata
    Background We evaluated the importance of high-density lipoprotein (HDL) functionality for target-lesion revascularization in patients treated with coronary stents using a rapid cell-free assay system to evaluate the functional capacity of HDL to accept additional cholesterol (cholesterol-uptake capacity; CUC). Methods and Results From an optical coherence tomography (OCT) registry of patients treated with coronary stents, 207 patients were enrolled and their HDL was functionally evaluated by measuring the CUC. Follow-up OCT was performed (median duration, 24.5 months after stenting) to evaluate the presence of neoatherosclerosis. Clinical follow-up was performed to assess target-lesion revascularization for a median duration of 42.3 months after stent implantation. Neoatherosclerosis was identified in 37 patients (17.9%). Multivariate logistic regression analysis revealed that a decreased CUC was independently associated with neoatherosclerosis (odds ratio, 0.799; P<0.001). The CUC showed a significant inverse correlation with incidence of target-lesion revascularization (odds ratio, 0.887; P=0.003) and with lipid accumulation inside stents, suggesting that neoatherosclerosis contributes to the association between CUC and target-lesion revascularization. Conclusions Impaired HDL functionality, detected as decreased CUC, might lead to future stent failure by provoking atherogenic changes of the neointima within stents. Both quantitative and qualitative assessments of HDL might enable the improved prediction of clinical outcomes after stent implantation.
    May 2019, Journal of the American Heart Association, 8(9) (9), e011975, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Naoki Tamada, Kazuhiko Nakayama, Kenichi Yanaka, Hiroyuki Onishi, Yuto Shinkura, Yu Taniguchi, Hiroto Kinutani, Yasunori Tsuboi, Kazuhiro P Izawa, Seimi Satomi-Kobayashi, Hiromasa Otake, Hiroshi Tanaka, Toshiro Shinke, Yutaka Okita, Noriaki Emoto, Ken-Ichi Hirata
    Background: While hemodynamics and exercise capacity in patients with chronic thromboembolic pulmonary hypertension (CTEPH) can be improved by invasive therapy such as pulmonary endarterectomy (PEA) and balloon pulmonary angioplasty (BPA), there has been little data on the health-related quality of life (HRQOL) in such patients. Methods and Results: This single-center and observational study compared the impact of invasive therapy on HRQOL. We utilized the Medical Outcome Study 36-Item Short Health Survey (SF-36) to measure HRQOL and compared HRQOL changes after PEA and BPA. A total of 48 patients were diagnosed with CTEPH. Of these, 39 patients completed questionnaires before and after invasive therapy. The PEA group (n=15) and the BPA group (n=24) had similar improvements in clinical parameters. With regard to HRQOL score, both groups had fairly low scores in physical functioning (PF), role physical (RP), general health (GH), social functioning (SF), role emotional (RE), and physical component summary (PCS) at baseline. PF, GH, vitality (VT), mental health (MH), and PCS had significant improvements in the PEA group while PCS and all subscales except for bodily pain (BP) had significant improvements in the BPA group. Furthermore, changes between baseline and follow-up were not significantly different between the 2 groups. Conclusions: BPA for patients who are ineligible for PEA can recover HRQOL to a similar level to that achieved by PEA.
    Apr. 2019, Circulation reports, 1(5) (5), 228 - 234, English, Domestic magazine
    [Refereed]
    Scientific journal

  • ステント留置後の不規則な膨隆は将来の新たなアテローム性動脈硬化症の発現と関連する MECHANISM-AMI研究からの知見(Post-stent Irregular Protrusion is Associated with Future Development of Neoatherosclerosis: Insights from the MECHANISM-AMI Study)
    築山 義朗, 新家 俊郎, 大竹 寛雅, 石田 大, 寺下 大輔, 房崎 哲也, 菊池 達郎, 岡村 誉之, 森田 孝, 片岡 亨, 日比 潔, 石原 昭三, 森野 禎浩, 平田 健一
    (一社)日本循環器学会, Mar. 2019, 日本循環器学会学術集会抄録集, 83回, OJ16 - 5, English

  • 安定狭心症とST上昇型心筋梗塞間で異なるeverolimus溶出性ステント留置に対する血管反応 MECHANISM試験からの洞察(Different Vascular Reaction to Everolimus-eluting Stents Implantation between Stable Angina and ST Elevation Myocardial Infarction: Insights from MECHANISM Studies)
    築山 義朗, 新家 俊郎, 大竹 寛雅, 石田 大, 寺下 大輔, 房崎 哲也, 菊池 達郎, 岡村 誉之, 森田 孝, 片岡 亨, 日比 潔, 石原 昭三, 森野 禎浩, 平田 健一
    (一社)日本循環器学会, Mar. 2019, 日本循環器学会学術集会抄録集, 83回, OJ39 - 4, English

  • JDS-JCSジョイントシンポ(Controversy or Debate)-"Stop DM for Stop CVD"生命予後改善のための糖尿病管理とは ブドウ糖変動が安定冠動脈疾患患者の心血管転帰に与える影響(The Impact of Glucose Fluctuation on Cardiovascular Outcome in Patients with Stable Coronary Artery Disease)
    山本 裕之, 大竹 寛雅, 新家 俊郎, 川森 裕之, 鳥羽 敬義, 永野 雄一朗, 築山 義朗, 谷仲 謙一, 長澤 智, 大西 裕之, 竹重 遼, 杉崎 陽一郎, 中野 槙介, 谷村 幸亮, 松岡 庸一郎, 福山 裕介, 高橋 悠, 廣田 勇士, 坂口 一彦, 平田 健一
    (一社)日本循環器学会, Mar. 2019, 日本循環器学会学術集会抄録集, 83回, SY12 - 2, English

  • Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Hidekazu Tanaka, Kensuke Matsumoto, Ken-Ichi Hirata
    It is well known that patent ductus arteriosus (PDA) in adults, especially in the elderly, differs from that in pediatric patients. A 68-year-old woman with a PDA with focal calcification at the aortic orifice of the ampulla with a minimum diameter of 4.0 mm and length of 14.8 mm, was treated with a 10/8-mm Amplatzer duct occluder (ADO) (St. Jude Medical Corp, St. Paul, MN, USA). After device implantation, systolic blood pressure (BP) increased to approximately 220 mmHg from 130 mmHg. She experienced transient dyspnea from hypertensive heart failure, which improved through continuous infusion of anti-hypertensive agents. She suddenly felt pressure on her chest 12 h post-procedure and collapsed. Surgical thoracotomy revealed an ascending aortic dissection into the pericardial space. In retrospective review, the ADO may have been slightly deformed by fluoroscopy. The complication may have been triggered by the resilience caused by device deformation, damage to the aortic wall due to the aortic side of the device, uneven elasticity of the arterial wall, and uncontrolled excessively high blood pressure. .
    Mar. 2019, Journal of cardiology cases, 19(3) (3), 85 - 88, English, Domestic magazine
    [Refereed]

  • Oshita T, Toh Ryuji, Shinohara M, Mori K, Irino Y, Nagao M, Hara T, Otake H, Ishida T, Hirata Ken-ichi
    BACKGROUND: Trans-fatty acid (TFA) intake increases the risk of coronary artery disease (CAD). Our previous cross-sectional survey showed that middle-aged patients with CAD in Japan have elevated serum TFA. In this study, we longitudinally investigated whether elevated TFA is a risk factor in the secondary prevention of CAD for the same-age patients. Methods and Results: A total of 112 patients (age, 21-66 years) who underwent percutaneous coronary intervention were followed up for up to 2 years. Serum elaidic acid was measured using gas chromatography/mass spectrometry as a marker of TFA intake and divided into quartiles. The primary endpoint was ischemia-driven target lesion revascularization (TLR). The hazard ratio (HR) for TLR increased significantly with higher serum elaidic acid (P<0.01). The significant positive trend remained unchanged after adjusting for conventional lipid profile and bare-metal stent usage. In contrast, although triglycerides and low-density lipoprotein cholesterol were positively correlated with elaidic acid, they were not associated with TLR. On multivariable Cox proportional hazard analysis, elevated elaidic acid was independently associated with TLR risk after adjusting for conventional coronary risks (HR, 10.7, P<0.01). CONCLUSIONS: Elevated elaidic acid is associated with higher TLR rate in middle-aged patients with CAD, suggesting that excessive TFA intake is becoming a serious health problem in Japan.
    Mar. 2019, Circ J, 83(5) (5), 1032 - 1038, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Otake Hiromasa, Sugizaki Y, Toba T, Nagano Y, Tsukiyama Y, Yanaka KI, Yamamoto H, Nagasawa A, Onishi H, Takeshige R, Nakano S, Matsuoka Y, Tanimura K, Kawamori Hiroyuki, Shinke T, Hirata Ken-ichi
    BACKGROUND: Although a recent clinical trial demonstrated that alirocumab, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, significantly reduces the incidence of acute coronary events, the impact of alirocumab on plaque stabilization remains uncertain. The Efficacy of ALirocumab for Thin-cap fibroatheroma in patients with coronary Artery disease estImated by optical coherence tomogRaphy (ALTAIR) study will investigate the effect of alirocumab on thin-cap fibroatheroma (TCFA) in Japanese patients who underwent recent percutaneous coronary intervention (PCI). METHODS AND DESIGN: ALTAIR is a phase IV, open-label, randomized, parallel-group, single-center study involving blinded optical coherence tomography (OCT) image analysis in Japanese adults hospitalized for PCI and having suboptimal control of low-density lipoprotein cholesterol (LDL-C) levels (>70mg/dL) despite statin therapy. Patients will be randomized (1:1) to the alirocumab arm (alirocumab 75mg every 2 weeks added to rosuvastatin 10mg/day) or the standard-of-care arm (rosuvastatin 10mg/day, with initiation and/or dose adjustment of non-statin lipid-lowering to achieve an LDL-C target of <70mg/dL). OCT imaging will be conducted at baseline and at week 36 (post-treatment). The primary objective is to compare the alirocumab and standard-of-care arms regarding the change in TCFA fibrous-cap thickness after 9 months of treatment. CONCLUSION: The outcomes of ALTAIR (ClinicalTrials.gov identifier: NCT03552432) will provide insights into the effect of alirocumab on plaque vulnerability following PCI in patients with suboptimal LDL-C control despite stable statin therapy.
    Mar. 2019, J Cardiol, 73(3) (3), 228 - 232, English, International magazine
    [Refereed]
    Scientific journal

  • Hiromasa Otake, Kosuke Tanimura, Yoichiro Sugizaki, Takayoshi Toba, Hiroyuki Kawamori, Toshiro Shinke, Ken-ichi Hirata
    Japanese Circulation Society, Feb. 2019, Circulation Reports, 1(2) (2), 107 - 111
    Scientific journal

  • Hiroyuki Yamamoto, Hiromasa Otake, Teiji Akagi, Kensuke Matsumoto, Soichiro Henmi, Takeshi Inoue, Hiroshi Tanaka, Ken-Ichi Hirata
    Jan. 2019, JACC. Cardiovascular interventions, 12(1) (1), e5-e7 - e7, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Toba T, Shinke T, Otake Hiromasa, Sugizaki Y, Takeshige R, Onishi H, Nagasawa A, Tsukiyama Y, Yanaka K, Nagano Y, Yamamoto H, Kawamori Hiroyuki, Matsuura A, Ishihara T, Matsumoto D, Igarashi N, Hayashi T, Yasaka Y, Kadotani M, Fujii T, Shite J, Okada M, Sakakibara T, Hirata KI
    The impact of dual antiplatelet therapy (DAPT) with adjusted-dose (3.75 mg/day) prasugrel for Japanese patients has not been fully investigated in terms of local arterial healing following the elective percutaneous coronary intervention (PCI). The ROUTE-01 elective study was a prospective, 12-center and single-arm registry that enrolled 123 patients who underwent elective PCI with everolimus-eluting stents (EESs) under DAPT with a combination of adjusted-dose prasugrel and aspirin. Serial optical coherence tomography (OCT) was performed at the index PCI and 9-month follow-up to assess the relationship between in-stent thorombus (IST) and residual platelet reactivity measuring platelet reactivity unit (PRU). The patients were classified as extensive, intermediate, and poor metabolizers by cytochrome P450 2C19 (CYP2C19) loss-of-function polymorphisms. The prevalence of IST was 9.0% by 9-month OCT, with no difference amongst the three groups (p = 0.886). The incidences of malapposed and uncovered struts were not different among the groups. PRU was not statistically different among the groups. In multivariate logistic regression analysis, the independent predictor for IST on 9-month OCT was irregular protrusion (odds ratio = 8.952, p = 0.037) on post-PCI OCT, not CYP2C19 loss-of-function polymorphisms. An adequate anti-thrombotic effect with an acceptable incidence of IST was observed irrespective of CYP2C19 loss-of-function polymorphisms. Our data suggests that adjusted-dose prasugrel and aspirin is a feasible treatment option in Japanese patients treated with EESs in elective PCI.
    Jan. 2019, Heart Vessels, 34(6) (6), 936 - 947, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Morino Y, Terashita D, Otake Hiromasa, Kikuchi T, Fusazaki T, Kuriyama N, Suzuki T, Ito Y, Hibi K, Tanaka H, Ishihara S, Kataoka T, Morita T, Otsuka Y, Hayashi T, Tanabe K, Shinke T
    The use of cobalt-chromium everolimus-eluting stents (CoCr-EES) for ST-segment elevation myocardial infarction (STEMI) reduces the incidence of stent thrombosis compared with bare metal stents, and a substantial difference is apparent in the initial 2 weeks. However, vascular behavior during this early period remains unclear. This was a prospective study (MECHANISM-AMI-2W) to investigate early vascular responses in STEMI patients immediately after CoCr-EES implantation and at 2-week follow-up using frequency domain-optical coherence tomography (FD-OCT). The study enrolled 52 patients (age 63.7 ± 11.7 years, male 85.0%), of whom 44 patients were available for complete serial FD-OCT analyses. Both % uncovered struts and % malapposed struts were improved at 2-week follow-up (63 ± 20 vs. 21 ± 14%, p < 0.0001 and 7.3 ± 9.0 vs. 4.7 ± 5.9%, p = 0.005, respectively). Thrombus was decreased, with significant changes in longitudinal length to stent (28.8 ± 27.7 vs. 18.1 ± 20.2%, p = 0.0001) and maximal area (0.93 ± 0.84 vs. 0.65 ± 0.63 mm2, p = 0.034). As a result, the average lumen area was significantly larger at 2 weeks (6.49 ± 1.82 vs. 6.71 ± 1.89 mm2, p = 0.048, respectively). The number of dissection flaps was lower (0.86 ± 1.11 vs. 0.52 ± 0.90%, p = 0.024). In conclusion, this study showed early vascular responses to CoCr-EES for STEMI lesions-including a significant reduction of thrombus-that resulted in lumen enlargement, earlier progression of strut coverage, and improvements in strut apposition and dissection. The combination of these factors may therefore be responsible for the safety of CoCr-EES within the initial 2 weeks.
    Jan. 2019, Cardiovasc Interv Ther, 34(1) (1), 14 - 24, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Impact of Cytochrome P450 2C19 Reduced-Function Polymorphism on Lesions and Clinical Outcome in Japanese Patients After Drug-eluting Stent Implantation
    Tahara N, Shinke T, Otake Hiromasa, Nishio R, Konishi A, Hirata Ken-ichi
    We previously reported that the cytochrome P450 (CYP) 2C19 reduced-function polymorphism was associated with decreased responsiveness to clopidogrel and intra-stent thrombus formation, as well as subsequent ischemic events after drug-eluting stent (DES) implantation. However, the relationship between the polymorphism and bleeding events remains unclear. Among 1427 consecutive patients who underwent DES implantation at Kobe University Hospital, 247 patients (341 lesions) were enrolled for this prospective observational study. All patients underwent follow-up optical coherence tomography (OCT) at 8 months and CYP2C19 genotyping. The patients were divided into three groups according to the phenotypic effect of the CYP2C19 polymorphism: extensive metabolizers (EM), intermediate metabolizers (IM), and poor metabolizers (PM). OCT findings, and ischemic and bleeding events were compared among the three groups. The frequency of intra-stent thrombi showed an increasing pattern among the patients with EM, IM, and PM (13.3%, 22.6%, and 33.3%, respectively; p = 0.04). The incidence of major adverse cardiovascular events (MACE) also showed an increase across the three groups from extensive to poor metabolizers (7.8%, 10.5%, and 33.3%, respectively; p < 0.01), whereas the frequency of bleeding showed no significant difference among the groups (15.6%, 19.4%, and 21.2%, respectively; p = 0.69). The CYP2C19 polymorphism is associated with the frequency of MACE, but is not related to the incidence of bleeding after percutaneous coronary intervention in Japanese patients receiving clopidogrel.
    Sep. 2018, Kobe J Med Sci, 64(2) (2), E56 - E63, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Konishi A, Iwasaki M, Shinke T, Otake Hiromasa, Takaya T, Osue T, Nishio R, Kinutani H, Kuroda M, Takahashi H, Terashita D, Shite J, Hirata Ken-ichi
    BACKGROUND: Although a prospective randomized control study revealed that 3-month dual anti-platelet therapy (DAPT) is safe and does not compromise the efficacy of everolimus-eluting stent (EES) in selected patients, detailed vessel healing at early phase after EES implantation has yet to be investigated in Japanese patients. METHODS AND RESULTS: A total of 27 lesions in 19 patients treated with EES were serially evaluated by using optical coherence tomography (OCT) at 3, 6, and 12 months after stent implantation. In addition to standard quantitative OCT parameters, the percentage of stents with peri-strut low-intensity area (PLIA, a region around stent struts homogenously showing lesser intensity than the surrounding tissue, suggesting fibrin deposition or impaired neointima maturation) and that with in-stent thrombi were evaluated. There was a significant, but small increase in neointimal thickness (63±17μm; 83±30μm; and 111±44μm, respectively; p=0.006) and small decrease in average lumen area (6.80±2.57mm2, 6.62±2.58mm2, 6.33±2.58mm2, p=0.038) from the 3- to the 12-month follow-up. The incidences of uncovered and malapposed struts were low at 3 months and did not significantly change at 6 months and 12 months (3.01±4.43; 2.45±3.75; and 1.47±3.16, p=0.143, and 0.75±0.65; 0.63±0.73; and 0.58±1.42, p=0.162, respectively). Also, frequency of struts with PLIA was already low at three months and significantly decreased during the follow-up (6.4±6.5; 4.6±5.4; and 2.3±3.3, respectively; p=0.001). CONCLUSION: Favorable vessel healing was achieved at 3 months after EES implantation without neointimal hyperplasia which was persistently suppressed up to 12 months.
    Sep. 2018, J Cardiol., 72(3) (3), 193 - 199, English, International magazine
    [Refereed]
    Scientific journal

  • Vascular response to biolimus A-9 eluting stent in patients with shorter and prolonged dual antiplatelet therapy: optical coherence tomography sub-study of the NIPPON trial.
    Kuroda K, Shinke T, OTAKE HIROMASA, Kinutani H, Iijima R, Ako J, Okada H, Ito Y, Ando K, Anzai H, Tanaka H, Ueda Y, Takiuchi S, Nishida Y, Ohira H, Kawaguchi K, Kadotani M, Niinuma H, Omiya K, Morita T, Zen K, Yasaka Y, Inoue K, Ishiwata S, Ochiai M, Hamasaki T, Urasawa K, Kataoka T, Yoshiyama M, Fujii K, Inoue T, Kawata M, Yokoi H, Nakamura M, NIPPON investigators
    Aug. 2018, Heart Vessels., 33(8) (8), 837 - 845, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Sugizaki Y, Mori S, Nagamatsu Y, Akita T, Nagasawa A, Toba T, Yamamoto Masatsugu, Nishii T, Obata Norihiko, Nomura Y, Otake Hiromasa, Shinke T, Okita Y, Hirata Ken-ichi
    An 82-year-old man with severe aortic stenosis and idiopathic pulmonary fibrosis (IPF) underwent transcatheter aortic valve implantation (TAVI) under general anesthesia. However, following a successful TAVI procedure, he developed progressive respiratory failure because of the exacerbation of IPF. Despite the use of immunosuppressants, the patient could not be saved and he died of respiratory failure. Although TAVI is a less invasive procedure compared to conventional surgical aortic valve replacement, it is currently selected for management of severely ill, frail, and elderly patients. This case highlights the potential risk of IPF exacerbation following a TAVI procedure performed under general anesthesia. .
    Aug. 2018, J CARDIOL CASES, 18(5) (5), 171 - 174, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve Assessment: Many Roads to Reach the Same Goal - Reply
    Otake Hiromasa, Taylor CA, Matsuo H, Tanaka N, Akasaka T
    Aug. 2018, Circ J, 82(9) (9), 2449, English
    [Refereed]
    Scientific journal

  • Konishi A, Iwasaki M, Shinke T, Otake Hiromasa, Nakagawa M, Hariki H, Osue T, Inoue T, Taniguchi Y, Nishio R, Kinutani H, Hiranuma N, Kuroda M, Hirata Ken-ichi, Saito S, Nakamura M, Shite J, Akasaka T
    Intra-stent thrombus (IS-Th) formed immediately after percutaneous coronary intervention (PCI) is associated with subsequent adverse coronary events. However, the impact of on-treatment platelet reactivity on IS-Th is unknown. PRASFIT-Elective is a multicenter study of PCI patients receiving prasugrel (20/3.75 mg, loading/maintenance dose) or clopidogrel (300/75 mg), with aspirin (100 mg). Among the 742 study patients, 111 were pre-specified for the OCT sub-study. Of these, 82 underwent OCT immediately after PCI to assess IS-Th and at an 8-month follow-up to evaluate the fate of the IS-Th. Lesions were considered resolved when IS-Th were detected after PCI but not on the follow-up or persistent when IS-Th were observed on both scans. The P2Y12 Reactive Unit (PRU) value was determined at the initial PCI and 4 and 48 weeks post-PCI. In 76 patients (86 lesions), we detected 230 IS-Th initially, and 196 IS-Th (85.2%) were resolved at the 8-month OCT. At PCI, but not 4 or 48 weeks after, the resolved IS-Th group had a lower PRU than the persistent IS-Th group (199 ± 101 vs. 266 ± 102, p = 0.008). Multivariate logistic regression analyses revealed that lower PRU at PCI and less calcified lesions were independent predictive factors for the resolution of IS-Th. Local lesion-related factors and lower on-treatment platelet reactivity at the time of PCI may contribute to the resolution of IS-Th after EES implantation, potentially improving clinical outcome.
    Jul. 2018, Heart Vessels., 33(12) (12), 1423 - 1433, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Impact of the angiographic burden on the incidence of out-of-hospital ventricular fibrillation in patients with acute myocardial infarction.
    Sugizaki Y, Shinke T, Doi T, Igarashi N, Otake Hiromasa, Kawamori Hiroyuki, Hirata Ken-ichi
    Jul. 2018, Heart Vessels., English
    [Refereed]
    Scientific journal

  • Hiroyuki Yamamoto, Naofumi Yoshida, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Kazuhiko Sakaguchi, Yushi Hirota, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Kouji Kuroda, Yoshinori Nagasawa, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-Ichi Yanaka, Takuo Emoto, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa, Ken-Ichi Hirata
    Data presented in this article are supplementary material to our research article entitled "Impact of CD14++CD16+ monocytes on coronary plaque vulnerability assessed by optical coherence tomography in coronary artery disease patients" [1]. This article contains the data of study population, diagnostic ability of CD14++CD16+ monocytes to identify thin-cap fibroatheromas, and association between laboratory variables and plaque properties.
    Jun. 2018, Data in brief, 18, 172 - 175, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yanaka K, Nakayama K, Shinke T, Shinkura Y, Taniguchi Y, Kinutani H, Tamada N, Onishi H, Tsuboi Y, Satomi-Kobayashi Seimi, OTAKE HIROMASA, Tanaka H, Okita Y, Emoto N, Hirata Ken-ichi
    BACKGROUND: Residual symptoms after pulmonary endarterectomy (PEA) remain as the clinical issues to be solved. Additional balloon pulmonary angioplasty (BPA) after PEA showed its efficacy with symptoms in a case series, although long-term spontaneous recovery of exercise ability after PEA was also reported. However, no studies have validated the clinical efficacy of additional BPA by directly comparing PEA with and without BPA. The aim of this study was to retrospectively evaluate the efficacy of additional BPA as a sequential hybrid therapy for chronic thromboembolic pulmonary hypertension after PEA. METHODS AND RESULTS: Among 44 patients with chronic thromboembolic pulmonary hypertension, 20 patients had residual symptoms after PEA. Of those, 10 patients underwent additional BPA (hybrid group) and were compared with the other 10 patients, who were followed up without BPA (PEA group). The period from PEA to additional BPA was 7.3±2.3 months. In hybrid group, mean pulmonary arterial pressure was significantly improved by PEA (40.6±1.8 to 26.9±3.1 mm Hg, P=0.001) and improved further (to 16.7±1.8 mm Hg, P=0.002) with additional BPA, which resulted in remarkable improvement in World Health Organization (WHO) functional class (pre- to post-BPA: class I/II/III/IV, 0/5/4/1 to 7/3/0/0; P<0.001). Compared with the PEA group at follow-up, the hybrid group achieved better mean pulmonary arterial pressure (18.7±1.7 versus 30.2±3.2 mm Hg, P=0.008), WHO functional class (class I/II/III/IV, 7/3/0/0 versus 0/8/2/0; P=0.001), and 6-minute walking distance (429±38 versus 319±22 m, P=0.028). CONCLUSIONS: A sequential hybrid strategy improved residual symptoms and exercise capacity compared with single-PEA therapy.
    Jun. 2018, J Am Heart Assoc., 7(13) (13), English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Early Introduction of Pulmonary Endarterectomy or Balloon Pulmonary Angioplasty Contributes to Better Health-Related Quality of Life in Patients With Chronic Thromboembolic Pulmonary Hypertension.
    Tamada N, Nakayama K, Yanaka K, Onishi H, Shinkura Y, Tsuboi Y, Izawa KP, Satomo-Kobayashi Seimi, Otake Hiromasa, Tanaka H, Shinke T, Okita Y, Emoto N, Hirata Ken-ichi
    Jun. 2018, JACC Cardiovasc Interv., 11(11) (11), 1114 - 1116, English
    [Refereed]
    Scientific journal

  • Lumen Boundaries Extracted from Coronary Computed Tomography Angiography on Computed Fractional Flow Reserve (FFRCT): Validation with Optical Coherence Tomography.
    Uzu K, Otake Hiromasa, Choi G, Toba T, Kim HJ, Roy A, Schaap M, Grady L, Kawata M, Shinke T, Taylor CA, Hirata Ken-ichi
    Apr. 2018, EuroIntervention., English
    [Refereed]
    Scientific journal

  • Yuto Shinkura, Kazuhiko Nakayama, Kenichi Yanaka, Hiroto Kinutani, Naoki Tamada, Yasunori Tsuboi, Seimi Satomi-Kobayashi, Hiromasa Otake, Toshiro Shinke, Noriaki Emoto, Ken-Ichi Hirata
    EuroPCR, Apr. 2018, EuroIntervention, 13(17) (17), 2060 - 2068, English
    [Refereed]
    International conference proceedings

  • Identification of High-Risk Plaques Destined to Cause Acute Coronary Syndrome Using Coronary Computed Tomographic Angiography and Computational Fluid Dynamics.
    Lee JM, Choi G, Koo BK, Hwang D, Park J, Zhang J, Kim KJ, Tong Y, Kim HJ, Grady L, Doh JH, Nam CW, Shin ES, Cho YS, Choi SY, Chun EJ, Choi JH, Nørgaard BL, Christiansen EH, Niemen K, Otake Hiromasa, Penicka M, de Bruyne B, Kubo T, Akasaka T, Narula J, Douglas PS, Taylor CA, Kim HS
    Mar. 2018, JACC Cardiovasc Imaging., English
    [Refereed]
    Scientific journal

  • Yutaka Hatani, Hidekazu Tanaka, Yasuhide Mochizuki, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Yoshiki Motoji, Keiko Ryo-Koriyama, Kensuke Matsumoto, Hiromasa Otake, Toshiro Shinke, Ken-Ichi Hirata
    OBJECTIVES: The closure of atrial septal defect (ASD) results in normalized left ventricular (LV) and right ventricular (RV) geometry, and can increase LV stroke volume (LVSV), but the parameters associated with this increase after the closure of ASD remain uncertain. METHODS: Seventy ASD patients, who underwent transcatheter closure, were studied. Their mean age was 57.80 ± 16.88 years, 42 (60%) were female, and LV ejection fraction (LVEF) was 66.76% ± 7.91% (all ≥55%). Transthoracic echocardiography was performed before and 3 months after the procedure. Global longitudinal strain (GLS) was determined as the average peak speckle tracking strain of 18 segments from the 3 standard apical views, LV dispersion was defined as standard deviation of time-to-peak strain from the same views, and RV systolic function was calculated by averaging the 3-regional peak speckle tracking longitudinal strains from the RV free wall. A significant relative increase in LVSV between before and 3 months after the closure was defined as ∆LVSV ≥15%. Twenty age-, gender-, and LVEF-matched controls served as the control group. RESULTS: Global longitudinal strain (GLS) and RV free wall strain were similar for ASD patients and controls, but LV dispersion in ASD patients was significantly larger. Global longitudinal strain (GLS) remained unchanged after transcatheter closure, whereas RV free wall strain and LV dispersion decreased significantly. An important finding of the multivariate logistic regression analysis showed that ∆LV dispersion was the only independent determinant of increased LVSV after the closure (OR 1.023; 95% CI 1.001-1.046; P < .01). CONCLUSIONS: The assessment of LV dispersion may well have clinical implications for better management of ASD patients after transcatheter closure.
    Feb. 2018, Echocardiography (Mount Kisco, N.Y.), 35(2) (2), 218 - 226, English, International magazine
    [Refereed]
    Scientific journal

  • Hiroyuki Yamamoto, Naofumi Yoshida, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Kazuhiko Sakaguchi, Yushi Hirota, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Kouji Kuroda, Yoshinori Nagasawa, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-Ichi Yanaka, Takuo Emoto, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa, Ken-Ichi Hirata
    BACKGROUND AND AIMS: This study examined the impact of CD14++CD16+ monocytes on coronary plaque vulnerability, as assessed by optical coherence tomography (OCT), and investigated their association with daily glucose fluctuation. Although increased CD14++CD16+ monocyte levels have been reported to increase cardiovascular events, their impact on coronary plaque vulnerability in coronary artery disease (CAD) patients with or without diabetes mellitus (DM) remains unclear. METHODS: This prospective observational study included 50 consecutive patients with CAD, receiving lipid-lowering therapy and undergoing coronary angiography and OCT. Patients were divided into 3 tertiles according to the CD14++CD16+ monocyte percentages assessed by flow cytometry. Standard OCT parameters were assessed for 97 angiographically intermediate lesions (diameter stenosis: 30-70%). Daily glucose fluctuation was analyzed by measuring the mean amplitude of glycemic excursion (MAGE). RESULTS: CD14++CD16+ monocytes negatively correlated with fibrous cap thickness (r = -0.508, p < 0.01). The presence of thin-cap fibroatheroma (TCFA) was increased stepwise according to the tertile of CD14++CD16+ monocytes (0 [tertile 1] vs. 5 [tertile 2] vs. 10 [tertile 3], p < 0.01). CD14++CD16+ monocytes were a significant determinant of TCFA (OR 1.279, p = 0.001). In non-DM patients, a significant relationship was found between CD14++CD16+ monocytes and MAGE (r = 0.477, p = 0.018). CONCLUSIONS: CD14++CD16+ monocytes were associated with coronary plaque vulnerability in CAD patients with well-regulated lipid levels both in DM and non-DM patients. Cross-talk between glucose fluctuation and CD14++CD16+ monocytes may enhance plaque vulnerability, particularly in non-DM patients. CD14++CD16+ monocytes could be a possible therapeutic target for coronary plaque stabilization.
    Feb. 2018, Atherosclerosis, 269, 245 - 251, English, International magazine
    [Refereed]
    Scientific journal

  • Hiromasa Otake, on behalf of the, Takashi Kubo, Hachidai Takahashi, Toshiro Shinke, Takayuki Okamura, Kiyoshi Hibi, Gaku Nakazawa, Yoshihiro Morino, Junya Shite, Tetsuya Fusazaki, Ken Kozuma, Tetsuya Ioji, Hideaki Kaneda, Takashi Akasaka
    Elsevier Inc., Jan. 2018, JACC: Cardiovascular Imaging, 11(1) (1), 111 - 123, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Morino Y, Terashita D, Otake Hiromasa, Kikuchi T, Fusazaki T, Kuriyama N, Suzuki T, Ito Y, Hibi K, Tanaka H, Ishihara S, Kataoka T, Morita T, Otsuka Y, Hayashi T, Tanabe K, Shinke T
    The use of cobalt-chromium everolimus-eluting stents (CoCr-EES) for ST-segment elevation myocardial infarction (STEMI) reduces the incidence of stent thrombosis compared with bare metal stents, and a substantial difference is apparent in the initial 2 weeks. However, vascular behavior during this early period remains unclear. This was a prospective study (MECHANISM-AMI-2W) to investigate early vascular responses in STEMI patients immediately after CoCr-EES implantation and at 2-week follow-up using frequency domain-optical coherence tomography (FD-OCT). The study enrolled 52 patients (age 63.7 ± 11.7 years, male 85.0%), of whom 44 patients were available for complete serial FD-OCT analyses. Both % uncovered struts and % malapposed struts were improved at 2-week follow-up (63 ± 20 vs. 21 ± 14%, p < 0.0001 and 7.3 ± 9.0 vs. 4.7 ± 5.9%, p = 0.005, respectively). Thrombus was decreased, with significant changes in longitudinal length to stent (28.8 ± 27.7 vs. 18.1 ± 20.2%, p = 0.0001) and maximal area (0.93 ± 0.84 vs. 0.65 ± 0.63 mm2, p = 0.034). As a result, the average lumen area was significantly larger at 2 weeks (6.49 ± 1.82 vs. 6.71 ± 1.89 mm2, p = 0.048, respectively). The number of dissection flaps was lower (0.86 ± 1.11 vs. 0.52 ± 0.90%, p = 0.024). In conclusion, this study showed early vascular responses to CoCr-EES for STEMI lesions-including a significant reduction of thrombus-that resulted in lumen enlargement, earlier progression of strut coverage, and improvements in strut apposition and dissection. The combination of these factors may therefore be responsible for the safety of CoCr-EES within the initial 2 weeks.
    Jan. 2018, Cardiovasc Interv Ther., 34(1) (1), 14 - 24, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yoshiro Tsukiyama, Amane Kozuki, Toshiro Shinke, Hiromasa Otake, Yoichi Kijima, Tomoya Masano, Ryoji Nagoshi, Hiroyuki Shibata, Ryo Takeshige, Ken-ichi Yanaka, Junya Shite, Ken-ichi Hirata
    Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai), 2018, Journal of Cardiology, English
    [Refereed]
    Scientific journal

  • Takashi Kubo, Toshiro Shinke, Takayuki Okamura, Kiyoshi Hibi, Gaku Nakazawa, Yoshihiro Morino, Junya Shite, Tetsuya Fusazaki, Hiromasa Otake, Ken Kozuma, Tetsuya Ioji, Hideaki Kaneda, Takeshi Serikawa, Toru Kataoka, Hisayuki Okada, Takashi Akasaka
    Nov. 2017, EUROPEAN HEART JOURNAL, 38(42) (42), 3139 - 3147, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Kenzo Uzu, Toshiro Shinke, Hiromasa Otake, Tomofumi Takaya, Tsuyoshi Osue, Masamichi Iwasaki, Hiroto Kinutani, Akihide Konishi, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Ken-ichi Hirata, Shigeru Saito, Masato Nakamura, Junya Shite, Takashi Akasaka
    Nov. 2017, JOURNAL OF CARDIOLOGY, 70(5-6) (5-6), 545 - 552, English
    [Refereed]
    Scientific journal

  • Yoshinori Nagasawa, Toshiro Shinke, Ryuji Toh, Tatsuro Ishida, Hiromasa Otake, Tomofumi Takaya, Daisuke Sugiyama, Takayosi Toba, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Natsuko Tahara, Yuto Shinkura, Kenzo Uzu, Daiji Kashiwagi, Koji Kuroda, Yuichiro Nagano, Hiroyuki Yamamoto, Kenichi Yanaka, Yoshiro Tsukiyama, Ken-ichi Hirata
    Oct. 2017, ATHEROSCLEROSIS, 265, 312 - 317, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yuya Taguchi, Tomonori Itoh, Hideto Oda, Yohei Uchimura, Kyosuke Kaneko, Tsubasa Sakamoto, Iwao Goto, Masafumi Sakuma, Masaru Ishida, Daisuke Terashita, Hiromasa Otake, Yoshihiro Morino, Toshiro Shinke
    Oct. 2017, ATHEROSCLEROSIS, 265, 117 - 123, English
    [Refereed]
    Scientific journal

  • Hiromasa Otake, Charles A. Taylor, Hitoshi Matsuo, Nobuhiro Tanaka, Takashi Akasaka
    Aug. 2017, CIRCULATION JOURNAL, 81(8) (8), 1085 - 1093, English
    [Refereed]
    Scientific journal

  • Naofumi Yoshida, Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Daisuke Terashita, Hachidai Takahashi, Kazuhiko Sakaguchi, Yushi Hirota, Takuo Emoto, Hilman Zulkifli Amin, Taiji Mizoguchi, Tomohiro Hayashi, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa, Ken-Ichi Hirata
    Aug. 2017, CARDIOVASCULAR DIABETOLOGY, 16, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takayoshi Toba, Shumpei Mori, Atsushi Yatani, Yoichiro Sugisaki, Tomomi Akita, Naoto Sasaki, Hiromasa Otake, Toshiro Shinke, Hiroyuki Mori, Tatsuya Nishii, Atsushi K. Kono, Ken-ichi Hirata
    Jul. 2017, JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, 11(4) (4), 324 - 326, English
    [Refereed]
    Scientific journal

  • Masaru Kuroda, Hiromasa Otake, Toshiro Shinke, Tomofumi Takaya, Masayuki Nakagawa, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Hiroto Kinutani, Akihide Konishi, Ken-Ichi Hirata
    EuroPCR, Dec. 2016, EuroIntervention, 12(11) (11), e1366 - e1374, English
    [Refereed]
    Scientific journal

  • Takashi Kubo, Toshiro Shinke, Takayuki Okamura, Kiyoshi Hibi, Gaku Nakazawa, Yoshihiro Morino, Junya Shite, Tetsuya Fusazaki, Hiromasa Otake, Ken Kozuma, Takashi Akasaka
    Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai), Nov. 2016, Journal of Cardiology, 68(5) (5), 455 - 460, English
    [Refereed]
    Scientific journal

  • Takashi Kubo, Toshiro Shinke, Takayuki Okamura, Kiyoshi Hibi, Gaku Nakazawa, Yoshihiro Morino, Junya Shite, Tetsuya Fusazaki, Hiromasa Otake, Ken Kozuma, Takashi Akasaka
    Nov. 2016, JOURNAL OF CARDIOLOGY, 68(5-6) (5-6), 455 - 460, English
    [Refereed]
    Scientific journal

  • Hachidai Takahashi, Hiromasa Otake, Toshiro Shinke, Yoshinobu Murasato, Yoshihisa Kinoshita, Masahiro Yamawaki, Yoshihiro Takeda, Kenichi Fujii, Shin-ichiro Yamada, Yoshihisa Shimada, Takehiro Yamashita, Kazuhiko Yumoto, Ken-ichi Hirata
    Nov. 2016, JOURNAL OF CARDIOLOGY, 68(5-6) (5-6), 504 - 511, English
    [Refereed]
    Scientific journal

  • Jun-Bean Park, Gilwoo Choi, Eun Ju Chun, Hyun Jin Kim, Jonghanne Park, Ji-Hyun Jung, Min-Ho Lee, Hiromasa Otake, Joon-Hyung Doh, Chang-Wook Nam, Eun-Seok Shin, Bernard De Bruyne, Charles A. Taylor, Bon-Kwon Koo
    Oct. 2016, HEART, 102(20) (20), 1655 - 1661, English
    [Refereed]
    Scientific journal

  • Claudio Chiastra, Wei Wu, Benjamin Dickerhoff, Ali Aleiou, Gabriele Dubini, Hiromasa Otake, Francesco Migliavacca, John F. LaDisa
    Elsevier Ltd, Jul. 2016, Journal of Biomechanics, 49(11) (11), 2102 - 2111, English
    [Refereed]
    Scientific journal

  • Akihide Konishi, Toshiro Shinke, Hiromasa Otake, Tomofumi Takaya, Tsuyoshi Osue, Hiroto Kinutani, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Ken-ichi Hirata
    Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai), Jun. 2016, Journal of Cardiology, 67(6) (6), 531 - 537, English
    [Refereed]
    Scientific journal

  • Amane Kozuki, Toshiro Shinke, Hiromasa Otake, Yoichi Kijima, Tomoya Masano, Ryoji Nagoshi, Kimitake Imamura, Ryudo Fujiwara, Hiroyuki Shibata, Ryo Takeshige, Yoshiro Tsukiyama, Kenichi Yanaka, Shinsuke Nakano, Yusuke Fukuyama, Seinosuke Kawashima, Ken-ichi Hirata, Junya Shite
    Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai), May 2016, Journal of Cardiology, 67(5) (5), 424 - 429, English
    [Refereed]
    Scientific journal

  • Transient Ischemic Right Axis Deviation Tendency of the Frontal Plane QRS Axis in a Case of Inferior Myocardial Ischemia
    Kohei Hasegawa, Tomofumi Takaya, Shumpei Mori, Fumitaka Soga, Hachidai Takahashi, Daisuke Terashita, Hiromasa Otake, Ken-ichi Hirata
    May 2016, INTERNATIONAL HEART JOURNAL, 57(3) (3), 363 - 366, English
    [Refereed]
    Scientific journal

  • Masaru Kuroda, Toshiro Shinke, Hiromasa Otake, Daisuke Sugiyama, Tomofumi Takaya, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Daiji Kashiwagi, Koji Kuroda, Yuto Shinkura, Yoshinori Nagasawa, Kazuhiko Sakaguchi, Yushi Hirota, Wataru Ogawa, Ken-ichi Hirata
    May 2016, CARDIOVASCULAR DIABETOLOGY, 15(1) (1), 79, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Daisuke Terashita, Hiromasa Otake, Toshiro Shinke, Yoshinobu Murasato, Yoshihisa Kinoshita, Masahiro Yamawaki, Yoshihiro Takeda, Kenichi Fujii, Shin-ichiro Yamada, Yoshihisa Shimada, Takehiro Yamashita, Kazuhiko Yumoto, Ken-ichi Hirata
    Pulsus Group Inc., Mar. 2016, Canadian Journal of Cardiology, 32(3) (3), 384 - 390, English
    [Refereed]
    Scientific journal

  • M. Kuroda, T. Shinke, K. Sakaguchi, H. Otake, T. Takaya, Y. Hirota, D. Sugiyama, M. Nakagawa, H. Hariki, T. Inoue, T. Osue, Y. Taniguchi, M. Iwasaki, R. Nishio, H. Kinutani, A. Konishi, N. Hiranuma, H. Takahashi, D. Terashita, K. Hirata
    Mary Ann Liebert Inc., Feb. 2016, Diabetes Technology and Therapeutics, 18, S13 - S14, English

  • Yoshinobu Murasato, Yoshihisa Kinoshita, Masahiro Yamawaki, Toshiro Shinke, Hiromasa Otake, Yoshihiro Takeda, Kenichi Fujii, Shin-ichiro Yamada, Yoshihisa Shimada, Takehiro Yamashita, Kazuhiko Yumoto, Yoshihisa Fujino
    Feb. 2016, EUROINTERVENTION, 11(11) (11), E1237 - E1248, English
    [Refereed]
    Scientific journal

  • Takuma Sawa, Hidekazu Tanaka, Yoshiki Motoji, Mana Hiraishi, Yasuhide Mochizuki, Keiko Ryo, Kensuke Matsumoto, Hiromasa Otake, Toshiro Shinke, Ken-ichi Hirata
    Jan. 2016, ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 33(1) (1), 23 - 29, English
    [Refereed]
    Scientific journal

  • Yoshinobu Murasato, Yoshihisa Kinoshita, Masahiro Yamawaki, Toshiro Shinke, Hiromasa Otake, Yoshihiro Takeda, Kenichi Fujii, Shin-ichiro Yamada, Yoshihisa Shimada, Takehiro Yamashita, Kazuhiko Yumoto
    Springer Tokyo, Jan. 2016, Cardiovascular Intervention and Therapeutics, 31(1) (1), 1 - 12, English
    [Refereed]
    Scientific journal

  • Takuma Sawa, Hidekazu Tanaka, Yoshiki Motoji, Mana Hiraishi, Yasuhide Mochizuki, Keiko Ryo, Kensuke Matsumoto, Hiromasa Otake, Toshiro Shinke, Ken-Ichi Hirata
    Nov. 2015, Echocardiography (Mount Kisco, N.Y.), 32(11) (11), 1743 - 1743, English, International magazine
    [Refereed]
    Scientific journal

  • High perfusion pressure as predictor of reperfusion pulmonary injury after balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension.
    OTAKE HIROMASA
    Nov. 2015, Int J Cardiol Heart Vasc., English
    [Refereed]
    Scientific journal

  • Gilwoo Choi, Joo Myung Lee, Hyun-Jin Kim, Jun-Bean Park, Sethuraman Sankaran, Hiromasa Otake, Joon-Hyung Doh, Chang-Wook Nam, Eun-Seok Shin, Charles A. Taylor, Bon-Kwon Koo
    Oct. 2015, JACC-CARDIOVASCULAR IMAGING, 8(10) (10), 1156 - 1166, English
    [Refereed]
    Scientific journal

  • Peri-strut Low Intensity Area Assessed By Mid-term Follow-up Optical Coherence Tomography May Predict Target Lesion Revascularization After Stent Implantation
    Koji Kuroda, Hiromasa Otake, Toshiro Shinke, Tomofumi Takaya, Hiroto Kinutani, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Daiji Kashiwagi, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Yoshinori Nagasawa, Ken-ichi Hirata
    Oct. 2015, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B23 - B23, English
    [Refereed]
    Scientific journal

  • Toru Ozawa, Toshiro Shinke, Junya Shite, Hideyuki Takaoka, Nobutaka Inoue, Hidenari Matsumoto, Satoshi Watanabe, Ryohei Yoshikawa, Hiromasa Otake, Daisuke Matsumoto, Daisuke Ogasawara, Mitsuhiro Yokoyama, Ken-ichi Hirata
    Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai), Sep. 2015, Journal of Cardiology, 66(3) (3), 232 - 238, English
    [Refereed]
    Scientific journal

  • Toru Ozawa, Toshiro Shinke, Junya Shite, Hideyuki Takaoka, Nobutaka Inoue, Hidenari Matsumoto, Satoshi Watanabe, Ryohei Yoshikawa, Hiromasa Otake, Daisuke Matsumoto, Daisuke Ogasawara, Mitsuhiro Yokoyama, Ken-ichi Hirata
    Sep. 2015, JOURNAL OF CARDIOLOGY, 66(3-4) (3-4), 232 - 238, English
    [Refereed]
    Scientific journal

  • Akihide Konishi, Toshiro Shinke, Hiromasa Otake, Tomofumi Takaya, Tsuyoshi Osue, Hiroto Kinutani, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Junya Shite, Ken-ichi Hirata
    Aug. 2015, CANADIAN JOURNAL OF CARDIOLOGY, 31(8) (8), 980 - 988, English
    [Refereed]
    Scientific journal

  • Mitsuaki Itoh, Toshiro Shinke, Akihiro Yoshida, Amane Kozuki, Asumi Takei, Koji Fukuzawa, Kunihiko Kiuchi, Kimitake Imamura, Ryudo Fujiwara, Atsushi Suzuki, Tomoyuki Nakanishi, Soichiro Yamashita, Akinori Matsumoto, Hiromasa Otake, Ryoji Nagoshi, Junya Shite, Ken-Ichi Hirata
    Oxford University Press, Jul. 2015, Europace, 17(9) (9), 1407 - 1414, English
    [Refereed]
    Scientific journal

  • Early Phase Arterial Reaction Following Drug-Eluting and Bare-Metal Stent Implantation in Patients With ST-Segment Elevation Myocardial Infarction Optical Coherence Tomography Assessment at 2 Weeks
    Ryo Nishio, Toshiro Shinke, Yoshihiro Morino, Kengo Tanabe, Jungo Furuya, Kaname Takizawa, Junya Ako, Ken Kozuma, Kiyoshi Hibi, Hideki Ishii, Atsushi Hirohata, Yoritaka Otsuka, Hiromasa Otake, Tomofumi Takaya, Ken-ichi Hirata
    Jul. 2015, INTERNATIONAL HEART JOURNAL, 56(4) (4), 389 - 394, English
    [Refereed]
    Scientific journal

  • Masaru Kuroda, Toshiro Shinke, Kazuhiko Sakaguchi, Hiromasa Otake, Tomofumi Takaya, Yushi Hirota, Tsuyoshi Osue, Hiroto Kinutani, Akihide Konishi, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Ken-ichi Hirata
    Jun. 2015, CARDIOVASCULAR DIABETOLOGY, 14, 78, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Masaru Kuroda, Toshiro Shinke, Kazuhiko Sakaguchi, Hiromasa Otake, Tomofumi Takaya, Yushi Hirota, Daisuke Sugiyama, Masayuki Nakagawa, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Hiroto Kinutani, Akihide Konishi, Noritoshi Hiranuma, Hachidai Takahashi, Daisuke Terashita, Ken-ichi Hirata
    May 2015, JACC-CARDIOVASCULAR INTERVENTIONS, 8(6) (6), 800 - 811, English
    [Refereed]
    Scientific journal

  • Yu Taniguchi, Hiromasa Otake, Toshiro Shinke, Masayuki Nakagawa, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Noritoshi Hiranuma, Ryo Nishio, Hiroto Kinutani, Masamichi Iwasaki, Akihide Konishi, Masaru Kuroda, Ken-ichi Hirata
    Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai), Apr. 2015, Journal of Cardiology, 65(4) (4), 298 - 304, English
    [Refereed]
    Scientific journal

  • Ryo Nakazato, Hiromasa Otake, Akihide Konishi, Masamichi Iwasaki, Bon-Kwon Koo, Hiroyuki Fukuya, Toshiro Shinke, Ken-ichi Hirata, Jonathon Leipsic, Daniel S. Berman, James K. Min
    Apr. 2015, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 16(4) (4), 373 - 379, English
    [Refereed]
    Scientific journal

  • David J. Quam, Timothy J. Gundert, Laura Ellwein, Christopher E. Larkee, Paul Hayden, Raymond Q. Migrino, Hiromasa Otake, John F. LaDisa
    Mar. 2015, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 137(3) (3), English
    [Refereed]
    Scientific journal

  • Akihide Konishi, Toshiro Shinke, Hiromasa Otake, Ryo Nishio, Takahiro Sawada, Tomofumi Takaya, Masayuki Nakagawa, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Hiroto Kinutani, Kuroda Masaru, Hachidai Takahashi, Daisuke Terashita, Junya Shite, Ken-ichi Hirata
    Jan. 2015, INTERNATIONAL JOURNAL OF CARDIOLOGY, 179, 476 - 483, English
    [Refereed]
    Scientific journal

  • Hyung-Bok Park, Ran Heo, Briain O. Hartaigh, Iksung Cho, Heidi Gransar, Ryo Nakazato, Jonathon Leipsic, G. B. John Mancini, Bon-Kwon Koo, Hiromasa Otake, Matthew J. Budoff, Daniel S. Berman, Andrejs Erglis, Hyuk-Jae Chang, James K. Min
    Jan. 2015, JACC-CARDIOVASCULAR IMAGING, 8(1) (1), 1 - 10, English
    [Refereed]
    Scientific journal

  • Noritoshi Hiranuma, Toshiro Shinke, Gaku Nakazawa, Hiromasa Otake, Daisuke Matsumoto, Takeshi Ijichi, Hiroyuki Kawamori, Ryoji Nagoshi, Tsuyoshi Osue, Junya Shite, Ken-ichi Hirata
    Nov. 2014, CIRCULATION JOURNAL, 78(11) (11), 2665 - 2673, English
    [Refereed]
    Scientific journal

  • Gaku Nakazawa, Toshiro Shinke, Takeshi Ijichi, Daisuke Matsumoto, Hiromasa Otake, Sho Torii, Noritoshi Hiranuma, Tsuyoshi Ohsue, Fumiyuki Otsuka, Junya Shite, Ken-ichi Hirata, Yuji Ikari
    Oct. 2014, EUROINTERVENTION, 10(6) (6), 717 - 723, English
    [Refereed]
    Scientific journal

  • Masamichi Iwasaki, Hiromasa Otake, Toshiro Shinke, Masayuki Nakagawa, Hirotoshi Hariki, Tsuyoshi Osue, Takumi Inoue, Yu Taniguchi, Ryo Nishio, Hiroto Kinutani, Akihide Konishi, Noritoshi Hiranuma, Masaru Kuroda, Junya Shite, Ken-ichi Hirata
    Sep. 2014, CIRCULATION JOURNAL, 78(9) (9), 2188 - U294, English
    [Refereed]
    Scientific journal

  • Akihide Konishi, Toshiro Shinke, Hiromasa Otake, Tomofumi Takaya, Masayuki Nakagawa, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Hiroto Kinutani, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Junya Shite, Ken-ichi Hirata
    Aug. 2014, CIRCULATION JOURNAL, 78(8) (8), 1882 - 1890, English
    [Refereed]
    Scientific journal

  • Masayuki Nakagawa, Hiromasa Otake, Toshiro Shinke, Tomofumi Takaya, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Hiroto Kinutani, Akihide Konishi, Masaru Kuroda, Junya Shite, Ken-ichi Hirata
    Aug. 2014, CANADIAN JOURNAL OF CARDIOLOGY, 30(8) (8), 904 - 911, English
    [Refereed]
    Scientific journal

  • Akihide Konishi, Toshiro Shinke, Hiromasa Otake, Daisaku Nakatani, Masayuki Nakagawa, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Hiroto Kinutani, Masaru Kuroda, Junya Shite, Ken-ichi Hirata
    Jul. 2014, JOURNAL OF CARDIOLOGY, 64(1) (1), 25 - 31, English
    [Refereed]
    Scientific journal

  • Takumi Inoue, Toshiro Shinke, Hiromasa Otake, Masayuki Nakagawa, Hirotoshi Hariki, Tsuyoshi Osue, Masamichi Iwasaki, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Masaru Kuroda, Ken-ichi Hirata
    Jun. 2014, INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, 30(5) (5), 857 - 865, English
    [Refereed]
    Scientific journal

  • Ryo Nishio, Toshiro Shinke, Hiromasa Otake, Masayuki Nakagawa, Ryoji Nagoshi, Takumi Inoue, Amane Kozuki, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Junya Shite, Ken-ichi Hirata
    May 2014, ATHEROSCLEROSIS, 234(1) (1), 114 - 119, English
    [Refereed]
    Scientific journal

  • Ryo Nishio, Toshiro Shinke, Yoshihiro Morino, Kengo Tanabe, Jungo Furuya, Kaname Takizawa, Junya Ako, Ken Kozuma, Kiyoshi Hibi, Hideki Ishii, Atsushi Hirohata, Yoritaka Otsuka, Hiromasa Otake, Tomofumi Takaya, Ken-ichi Hirata
    Apr. 2014, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 63(12) (12), A1904 - A1904, English
    [Refereed]

  • Takumi Inoue, Toshiro Shinke, Hiromasa Otake, Masayuki Nakagawa, Hirotoshi Hariki, Tsuyoshi Osue, Masamichi Iwasaki, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Junya Shite, Ken-Ichi Hirata
    2014, Circulation Journal, 78(1) (1), 92 - 100, English
    [Refereed]
    Scientific journal

  • Ryo Nishio, Toshiro Shinke, Hiromasa Otake, Masayuki Nakagawa, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Masaru Kuroda, Ken-Ichi Hirata
    Nov. 2013, THROMBOSIS RESEARCH, 132(5) (5), 558 - 564, English
    [Refereed]
    Scientific journal

  • Amane Kozuki, Toshiro Shinke, Hiromasa Otake, Junya Shite, Masayuki Nakagawa, Ryoji Nagoshi, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Ryo Nishio, Ken-Ichi Hirata
    Oct. 2013, JACC: Cardiovascular Imaging, 6(10) (10), 1121 - 1123, English
    [Refereed]
    Scientific journal

  • 慢性血栓塞栓性肺高血圧症に対する肺動脈カテーテル治療と血栓内膜摘除術の比較
    谷口 悠, Shinke Toshiro, 絹谷 洋人, 宮川 一也, 中山 和彦, 大竹 寛雅, 江本 憲昭, Hirata Ken-ichi, 岡田 健次, 大北 裕
    Sep. 2013, 日本心臓病学会誌, 8(Suppl.I) (Suppl.I), 389, Japanese
    Research society

  • Freddy Abnousi, Katsuhisa Waseda, Teruyoshi Kume, Hiromasa Otake, Osami Kawarada, Celina M. Yong, Peter J. Fitzgerald, Yasuhiro Honda, Alan C. Yeung, William F. Fearon
    Sep. 2013, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 82(3) (3), E192 - E199, English
    [Refereed]
    Scientific journal

  • Hiroyuki Kawamori, Junya Shite, Toshiro Shinke, Hiromasa Otake, Daisuke Matsumoto, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Ken-ichi Hirata
    Sep. 2013, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 14(9) (9), 865 - 875, English
    [Refereed]
    Scientific journal

  • Takahiro Sawada, Toshiro Shinke, Hiromasa Otake, Taiji Mizoguchi, Masamichi Iwasaki, Takuo Emoto, Daisuke Terashita, Takao Mizuguchi, Hiroshi Okamoto, Yosuke Matsuo, Sushi-ku Kim, Akira Takarada, Mitsuhiro Yokoyama
    Sep. 2013, INTERNATIONAL JOURNAL OF CARDIOLOGY, 168(2) (2), 960 - 966, English
    [Refereed]
    Scientific journal

  • Amane Kozuki, Toshiro Shinke, Hiromasa Otake, Junya Shite, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Hirotoshi Hariki, Takumi Inoue, Ryo Nishio, Ken-Ichi Hirata
    Aug. 2013, International Journal of Cardiology, 167(4) (4), 1591 - 1596, English
    [Refereed]
    Scientific journal

  • The comorbidity of peripheral arterial disease attenuates complications during primary percutaneous coronary intervention in st-elevation myocardial infarction
    Alaa Mabrouk Salem Omar, Toshiro Shinke, Hiromasa Otake, Osama Rifaie, Hazem Khorshid, Masayuki Nakagawa, Takumi Inoue, Hirotoshi Hariki, Junya Shite, Ken-Ichi Hirata, Mohammad Abdel-Rahman
    Aug. 2013, Vascular Disease Management, 10(8) (8), E142 - E151, English
    Scientific journal

  • 各種血管イメージングの基礎 機能的評価と形態学的評価
    谷岡 怜, 加納 寛也, 大竹 寛雅, Shinke Toshiro, Hirata Ken-ichi
    May 2013, 日本心血管インターベンション治療学会誌, 5(Suppl.I) (Suppl.I), 466, Japanese
    Research society

  • Hirotoshi Hariki, Toshiro Shinke, Hiromasa Otake, Junya Shite, Masayuki Nakagawa, Takumi Inoue, Tsuyoshi Osue, Masamichi Iwasaki, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hiroto Kinutani, Akihide Konishi, Ken-ichi Hirata
    May 2013, CIRCULATION JOURNAL, 77(5) (5), 1193 - 1201, English
    [Refereed]
    Scientific journal

  • 第2世代Everolimus溶出性ステント留置後の血管治癒過程関する検討
    大竹 寛雅, Shinke Toshiro, 平田 健一
    Feb. 2013, 日本内科学会雑誌, 102(Suppl.) (Suppl.), 161, Japanese
    Research society

  • 【DES留置後の抗血小板薬の使い方】 ステント構造から見たDAPTの期間
    西尾 亮, 大竹 寛雅, Shinke Toshiro
    Jan. 2013, Coronary Intervention, 9(1号) (1号), 32 - 38, Japanese
    [Refereed]
    Scientific journal

  • Ryoji Nagoshi, Toshiro Shinke, Hiromasa Otake, Junya Shite, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Ohsue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Naoki Miyoshi, Tomofumi Takaya, Shinichiro Yamada, Yoshinori Yasaka, Takatoshi Hayashi, Mitsuhiro Yokoyama, Hiroki Kato, Makoto Kadotani, Yoshio Ohnishi, Ken-ichi Hirata
    2013, Circulation Journal, 77(3) (3), 652 - 660, English
    [Refereed]
    Scientific journal

  • Kenji Sakata, Katsuhisa Waseda, Teruyoshi Kume, Hiromasa Otake, Daisaku Nakatani, Paul G. Yock, Peter J. Fitzgerald, Yasuhiro Honda
    Dec. 2012, CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 5(6) (6), 763 - 771, English
    [Refereed]
    Scientific journal

  • Ryo Nishio, Toshiro Shinke, Hiromasa Otake, Takahiro Sawada, Yoko Haraguchi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Junya Shite, Ken-ichi Hirata
    Oct. 2012, CIRCULATION JOURNAL, 76(10) (10), 2348 - 2355, English
    [Refereed]
    Scientific journal

  • Shinke Toshiro, 西尾 亮, 大竹 寛雅, 志手 淳也
    社団法人日本循環器学会, Sep. 2012, 循環器専門医, 20(2号) (2号), 267 - 273, Japanese
    [Refereed]
    Scientific journal

  • Hiromasa Otake, Junya Shite, Toshiro Shinke, Naoki Miyoshi, Amane Kozuki, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Noritoshi Hiranuma, Ryo Nishio, Hiroto Kinutani, Ken-ichi Hirata
    Aug. 2012, CIRCULATION JOURNAL, 76(8) (8), 1880 - 1888, English
    [Refereed]
    Scientific journal

  • 最新心血管イメージング ここまで分かる、見える診療支援画像 光干渉断層撮影(OCT)画像の診かた
    谷岡 怜, 加納 寛也, 大竹 寛雅, Shinke Toshiro, 志手 淳也
    Jun. 2012, 日本心血管インターベンション治療学会誌, 4(Suppl.2) (Suppl.2), 418, Japanese
    [Refereed]
    Scientific journal

  • 血管内イメージングの最前線 OCTによる薬剤溶出性ステントの評価
    Otake Hiromasa, Shinke Toshiro, Hirata Kenichi
    Jun. 2012, 日本心臓病学会誌, 7(2号) (2号), 129 - 135, Japanese
    [Refereed]
    Scientific journal

  • Hiromasa Otake, Junya Shite, Fumiaki Ikeno, Toshiro Shinke, Tomohiko Teramoto, Naoki Miyoshi, Junya Ako, Yasuhiro Honda, Peter J. Fitzgerald, Ken-ichi Hirata
    May 2012, INTERNATIONAL JOURNAL OF CARDIOLOGY, 157(1) (1), 38 - 42, English
    [Refereed]
    Scientific journal

  • Konishi Akihide, Shite Junya, Shinke Toshiro, Nakatani Daisaku, Otake Hiromasa, Hirata Ken-ichi
    Mar. 2012, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E206
    [Refereed]

  • Guillermo J. Tearney, Evelyn Regar, Takashi Akasaka, Tom Adriaenssens, Peter Barlis, Hiram G. Bezerra, Brett Bouma, Nico Bruining, Jin-man Cho, Saqib Chowdhary, Marco A. Costa, Ranil de Silva, Jouke Dijkstra, Carlo Di Mario, Darius Dudeck, Erlin Falk, Marc D. Feldman, Peter Fitzgerald, Hector Garcia, Nieves Gonzalo, Juan F. Granada, Giulio Guagliumi, Niels R. Holm, Yasuhiro Honda, Fumiaki Ikeno, Masanori Kawasaki, Janusz Kochman, Lukasz Koltowski, Takashi Kubo, Teruyoshi Kume, Hiroyuki Kyono, Cheung Chi Simon Lam, Guy Lamouche, David P. Lee, Martin B. Leon, Akiko Maehara, Olivia Manfrini, Gary S. Mintz, Kyiouchi Mizuno, Marie-angele Morel, Seemantini Nadkarni, Hiroyuki Okura, Hiromasa Otake, Arkadiusz Pietrasik, Francesco Prati, Lorenz Raeber, Maria D. Radu, Johannes Rieber, Maria Riga, Andrew Rollins, Mireille Rosenberg, Vasile Sirbu, Patrick W. J. C. Serruys, Kenei Shimada, Toshiro Shinke, Junya Shite, Eliot Siegel, Shinjo Sonada, Melissa Suter, Shigeho Takarada, Atsushi Tanaka, Mitsuyasu Terashima, Thim Troels, Shiro Uemura, Giovanni J. Ughi, Heleen M. M. van Beusekom, Antonius F. W. van der Steen, Gerrit-Ann van Es, Gijs van Soest, Renu Virmani, Sergio Waxman, Neil J. Weissman, Giora Weisz
    Mar. 2012, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(12) (12), 1058 - 1072, English
    [Refereed]
    Scientific journal

  • Satoshi Watanabe, Junya Shite, Hideyuki Takaoka, Toshiro Shinke, Yusuke Tanino, Hiromasa Otake, Daisuke Matsumoto, Daisuke Ogasawara, Takahiro Sawada, Ken-ichi Hirata, Mitsuhiro Yokoyama
    Nov. 2011, JOURNAL OF CARDIOLOGY, 58(3) (3), 245 - 252, English
    [Refereed]
    Scientific journal

  • Daisaku Nakatani, Junya Ako, Jennifer A. Tremmel, Katsuhisa Waseda, Hiromasa Otake, Bon-Kwon Koo, Akiyoshi Miyazawa, Yoichiro Hongo, Seung-Ho Hur, Ryota Sakurai, Paul G. Yock, Yasuhiro Honda, Peter J. Fitzgerald
    Oct. 2011, AMERICAN JOURNAL OF CARDIOLOGY, 108(7) (7), 912 - 917, English
    [Refereed]
    Scientific journal

  • Laura M. Ellwein, Hiromasa Otake, Timothy J. Gundert, Bon-Kwon Koo, Toshiro Shinke, Yasuhiro Honda, Junya Shite, John F. LaDisa Jr.
    Sep. 2011, Cardiovascular Engineering and Technology, 2(3) (3), 212 - 227, English
    [Refereed]
    Scientific journal

  • Takumi Inoue, Junya Shite, Junghan Yoon, Toshiro Shinke, Hiromasa Otake, Takahiro Sawada, Hiroyuki Kawamori, Hiroki Katoh, Naoki Miyoshi, Naoki Yoshino, Amane Kozuki, Hirotoshi Hariki, Ken-ichi Hirata
    Sep. 2011, HEART, 97(17) (17), 1379 - 1384, English
    [Refereed]
    Scientific journal

  • Ability of optical coherence tomography to visualize the entry port of spontaneous coronary artery dissection.
    OTAKE HIROMASA
    Jul. 2011, Circ J., 75(10) (10), 2505 - 7, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Local determinants of thrombus formation following sirolimus-eluting stent implantation assessed by optical coherence tomography.
    OTAKE HIROMASA
    May 2011, JACC Cardiovasc Interv., 2, 459 - 466, English
    [Refereed]
    Scientific journal

  • Hiromasa Otake, Yasuhiro Honda, Brian K. Courtney, Takao Shimohama, Junya Ako, Katsuhisa Waseda, Nathalie Macours, Campbell Rogers, Jeffrey J. Popma, Alexandre Abizaid, John A. Ormiston, Christian Spaulding, Sidney A. Cohen, Peter J. Fitzgerald
    Apr. 2011, CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 4(2) (2), 146 - U69, English
    [Refereed]
    Scientific journal

  • Ruptured-plaque-like appearance of restenotic tissue following sirolimus-eluting stent implantation: An optical coherence tomography case study
    Hiromasa Otake, Junya Shite, Toshiro Shinke
    Mar. 2011, Journal of Invasive Cardiology, 23(3) (3), E49 - E50, English
    [Refereed]
    Scientific journal

  • Impact of Diabetes Mellitus on Vessel Response in the Drug-Eluting Stent Era: Pooled Volumetric Intravascular Ultrasound Analysis
    Sakata Kenji, Waseda Katsuhisa, Otake Hiromasa, Nakatani Daisaku, Kume Teruyoshi, Yock Paul G, Fitzgerald Peter J, Honda Yasuhiro
    Nov. 2010, CIRCULATION, 122(21) (21)
    [Refereed]

  • Impact of Mechanical Factor and Biologic Response on Severe In-Stent Lumen Narrowing in Currently Approved Drug-Eluting Stents
    Sakata Kenji, Waseda Katsuhisa, Otake Hiromasa, Nakatani Daisaku, Kume Teruyoshi, Yock Paul G, Fitzgerald Peter J, Honda Yasuhiro
    Nov. 2010, CIRCULATION, 122(21) (21)
    [Refereed]

  • CCR2 Antagonist Inhibits Neointimal Proliferation Post CoronaryStent Deployment
    Tomohiko Teramoto, Fumiaki Ikeno, Daisaku Nakatani, Hiromasa Otake, Jennifer K. Lyons, Tim Sullivan, Juan Jaen, Tom Schall, Fermin Tio, Alan C. Yeung, William F. Fearon
    Nov. 2010, CIRCULATION, 122(21) (21), English
    [Refereed]

  • The Ability of Optical Coherence Tomography to Monitor Percutaneous Coronary Intervention: Detailed Comparison with Intravascular Ultrasound
    Hiroyuki Kawamori, Junya Shite, Toshiro Shinke, Hiromasa Otake, Takahiro Sawada, Hiroki Kato, Naoki Miyoshi, Naoki Yoshino, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Ken-ichi Hirata
    Nov. 2010, JOURNAL OF INVASIVE CARDIOLOGY, 22(11) (11), 541 - 545, English
    [Refereed]
    Scientific journal

  • Hiromasa Otake, Junya Ako, Katsuhisa Waseda, Ryota Sakurai, Atsushi Hirohata, Hideaki Kaneda, Takao Hasegawa, Yasuhiro Honda, Peter J. Fitzgerald
    Nov. 2010, INTERNATIONAL JOURNAL OF CARDIOLOGY, 145(1) (1), 125 - 126, English
    Scientific journal

  • Impact of Lumen Narrowing Within Drug-Eluting Stents and Bare-Metal Stents on Downstream Vessel Segments
    Sakata Kenji, Waseda Katsuhisa, Otake Hiromasa, Nakatani Daisaku, Kume Teruyoshi, Ako Junya, Yock Paul G, Fitzgerald Peter J, Honda Yasuhiro
    Sep. 2010, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(13) (13), B15
    [Refereed]

  • Vessel Response to Drug-Eluting Stents in PatientsVVith vs. Without Diabetes Mellitus: Pooled Volumetric Intravascular Ultrasound Analysis
    Sakata Kenji, Waseda Katsuhisa, Otake Hiromasa, Nakatani Daisaku, Kume Teruyoshi, Yock Paul G, Fitzgerald Peter J, Honda Yasuhiro
    Sep. 2010, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(13) (13), B15
    [Refereed]

  • CCR2 Antagonist Inhibits Neointimal Proliferation Post Coronary Stent Deployment
    Tomohiko Teramoto, Fumiaki Ikeno, Daisaku Nakatani, Hiromasa Otake, Jennifer K. Lyons, Tim Sullivan, Juan Jaen, Tom Schall, Fermin Tio, William F. Fearon, Alan C. Yeung
    Sep. 2010, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(13) (13), B91 - B91, English
    [Refereed]

  • Bon-Kwon Koo, Katsuhisa Waseda, Junya Ako, Takao Hasegawa, Takao Shimohama, Daisaku Nakatani, Hiromasa Otake, Masao Yamasaki, Ryota Sakurai, Ichizo Tsujino, Yasuhiro Honda, Peter J. Fitzgerald
    Sep. 2010, INTERNATIONAL JOURNAL OF CARDIOLOGY, 144(1) (1), 132 - 134, English
    [Refereed]
    Scientific journal

  • Bon-Kwon Koo, Katsuhisa Waseda, Junya Ako, Takao Hasegawa, Takao Shimohama, Daisaku Nakatani, Hiromasa Otake, Masao Yamasaki, Ryota Sakurai, Ichizo Tsujino, Yasuhiro Honda, Peter J. Fitzgerald
    Sep. 2010, INTERNATIONAL JOURNAL OF CARDIOLOGY, 144(1) (1), 132 - 134, English
    Scientific journal

  • Hiromasa Otake, Junya Ako, Masao Yamasaki, Ichizo Tsujino, Takao Shimohama, Takao Hasegawa, Ryota Sakurai, Katsuhisa Waseda, Yasuhiro Honda, Poornima Sood, Krishnankutty Sudhir, Gregg W. Stone, Peter J. Fitzgerald
    Aug. 2010, AMERICAN JOURNAL OF CARDIOLOGY, 106(4) (4), 492 - 497, English
    Scientific journal

  • Takao Shimohama, Junya Ako, Masao Yamasaki, Hiromasa Otake, Ichizo Tsujino, Takao Hasegawa, Daisaku Nakatani, Ryota Sakurai, Hyeonsoo Chang, Hajime Kusano, Katsuhisa Waseda, Yasuhiro Honda, Gregg W. Stone, Shigeru Saito, Peter J. Fitzgerald, Krishnankutty Sudhir
    Jul. 2010, AMERICAN JOURNAL OF CARDIOLOGY, 106(1) (1), 13 - 17, English
    Scientific journal

  • Takahiro Sawada, Junya Shite, Toshiro Shinke, Hiromasa Otake, Yusuke Tanino, Daisuke Ogasawara, Hiroyuki Kawamori, Hiroki Kato, Naoki Miyoshi, Naoki Yoshino, Amane Kozuki, Ken-ichi Hirata
    Jul. 2010, INTERNATIONAL JOURNAL OF CARDIOLOGY, 142(3) (3), 250 - 256, English
    [Refereed]
    Scientific journal

  • Tomohiko Teramoto, Fumiaki Ikeno, Hiromasa Otake, Jennifer K. Lyons, Heleen M. M. van Beusekom, William F. Fearon, Alan C. Yeung
    Jun. 2010, CIRCULATION JOURNAL, 74(6) (6), 1257 - 1259, English
    Scientific journal

  • A randomised comparison of novolimus-eluting and zotarolimus-eluting coronary stents: 9-month follow-up results of the EXCELLA II study
    Patrick W. Serruys, Scot Garg, Alexandre Abizaid, John Ormiston, Stephan Windecker, Stefan Verheye, Christophe Dubois, Jim Stewart, Karl E. Hauptmann, Joachim Schafer, Karl Stangl, Bernhard Witzenbichler, Marcus Wiemer, Emanuele Barbato, Ton de Vries, Anne-Marie den Drijver, Hiromasa Otake, Lynn Meredith, Sara Tayloy, Peter Fitzgerald
    Jun. 2010, EUROINTERVENTION, 6(2) (2), 195 - 205, English
    Scientific journal

  • Hiromasa Otake, Yasuhiro Honda, Masao Yamasaki, Ichizo Tsujino, Takao Shimohama, Ryota Sakurai, Takao Hasegawa, Katsuhisa Waseda, Junya Ako, Peter J. Fitzgerald
    May 2010, CIRCULATION JOURNAL, 74(5) (5), 1023 - 1025, English
    Scientific journal

  • Naoki Miyoshi, Junya Shite, Toshiro Shinke, Hiromasa Otake, Yusuke Tanino, Daisuke Ogasawara, Takahiro Sawada, Hiroyuki Kawamori, Hiroki Kato, Naoki Yoshino, Amane Kozuki, Ken-ichi Hirata
    May 2010, CIRCULATION JOURNAL, 74(5) (5), 903 - 908, English
    [Refereed]
    Scientific journal

  • Preprocedural Inflammation Does Not Affect Neointimal Hyperplasia following Everolimus-Eluting Stent Implantation
    Daisaku Nakatani, Junya Ako, Masao Yamasaki, Takao Shimohama, Takao Hasegawa, Hiromasa Otake, Katsuhisa Waseda, Ichizo Tsujino, Ryota Sakurai, Bon-Kwon Koo, Hyeonsoo Chang, Paul G. Yock, Krishnankutty Sudhir, Wesley Pierson, Gregg W. Stone, Shigeru Saito, Yasuhiro Honda, Peter J. Fitzgerald
    Dec. 2009, JOURNAL OF INVASIVE CARDIOLOGY, 21(12) (12), 613 - 617, English
    [Refereed]
    Scientific journal

  • Serial Arterial Response to a Novel Drug-Eluting Stent with Novolimus, a Sirolimus Metabolite: IVUS Insights from the First Human Experience
    Otake Hiromasa, Nakatani Daisaku, Hasegawa Takao, Waseda Katsuhisa, Ako Junya, Honda Yasuhiro, Abizaid Alexandre, Fitzgerald Peter J
    Sep. 2009, AMERICAN JOURNAL OF CARDIOLOGY, 104(6A) (6A), 63D
    [Refereed]

  • Relative Dose and Vascular Response After Drug-Eluting Stent Implantation: A Dosimetric 3D-Intravascular Ultrasound Study
    Waseda Katsuhisa, Hasegawa Takao, Nakatani Daisaku, Koo Bon-Kwon, Otake Hiromasa, Shimohama Takao, Chang Hyeonsoo, Ako Junya, Yock Paul G, Fitzgerald Peter J, Honda Yasuhiro
    Mar. 2009, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(10) (10), A9
    [Refereed]

  • Intravascular Ultrasound Analysis of Vessel Response in Acute Coronary Syndrome Treated with Zotarolimus-Eluting Stents
    Nakatani Daisaku, Waseda Katsuhisa, Otake Hiromasa, Koo Bon-Kwon, Sakurai Ryota, Miyazawa Akiyoshi, Yamasaki Masao, Ako Junya, Chang Hyeonsoo, Fajadet Jean, Kuntz Richard E, Wijns William, Kandzari David E, Leon Martin B, Yock Paul G, Honda Yasuhiro, Fitzgerald Peter J
    Mar. 2009, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(10) (10), A15
    [Refereed]

  • Gender Difference in Vessel Response in Coronary Artery Disease Treated with Zotarolimus-Eluting Stents
    Nakatani Daisaku, Waseda Katsuhisa, Otake Hiromasa, Koo Bon-Kwon, Sakurai Ryota, Miyazawa Akiyoshi, Yamasaki Masao, Ako Junya, Chang Hyeonsoo, Fajadet Jean, Kuntz Richard E, Wijns William, Kandzari David E, Leon Martin B, Yock Paul G, Fitzgerald Peter J, Honda Yasuhiro
    Mar. 2009, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(10) (10), A94
    [Refereed]

  • Pioglitazone Reduces the Necrotic-Core Component in Coronary Plaque in Association With Enhanced Plasma Adiponectin in Patients With Type 2 Diabetes Mellitus
    Daisuke Ogasawara, Junya Shite, Toshiro Shinke, Satoshi Watanabe, Hiromasa Otake, Ylislike Tanino, Takahiro Sawada, Hiroyuki Kawamori, Hiroki Kato, Naoki Miyoshi, Ken-ichi Hirata
    Feb. 2009, CIRCULATION JOURNAL, 73(2) (2), 343 - 351, English
    [Refereed]
    Scientific journal

  • SPIRIT III Japan: Eight-Month IVUS Analysis of Everolimus-Elurting Stent Compared to the US Arm
    Shimohama Takao, Otake Hiromasa, Ako Junya, Yamasaki Masao, Tsujino Ichizo, Waseda Katsuhisa, Hasegawa Takao, Sakurai Ryota, Nakatani Daisaku, Chang Hyaonsoo, Yock Paul G, Honda Yasuhiro, Kusano Hajime, Sudhir Krishnankutty, Saito Shigeru, Stone Gregg W, Fitzgerald Peter J
    Oct. 2008, CIRCULATION, 118(18) (18), S1044
    [Refereed]

  • Incidence of Diffuse and Focal Chronic Stent Recoil after Implantation of Current Generation Bare-metal and Drug-eluting Stents
    Koo Bon-Kwon, Waseda Katsuhisa, Ako Junya, Hasegawa Takao, Shimohama Takao, Nakatani Daisaku, Otake Hiromasa, Chang Hyeonsoo, Fitzgerald Peter J, Honda Yasuhiro
    Oct. 2008, AMERICAN JOURNAL OF CARDIOLOGY, 102(8A) (8A), 197I
    [Refereed]

  • IVUS Analysis in the SPIRIT III Japan Treated with XIENCE (TM) V Everolimus-Eluting Stent Compared to the SPIRIT III US Arm
    Shimohama Takao, Otake Hiromasa, Ako Junya, Yamasaki Masao, Tsujino Ichizo, Waseda Katsuhisa, Hasegawa Takao, Sakurai Ryota, Nakatani Daisaku, Chang Hyeonsoo, Yock Paul G, Honda Yasuhiro, Kusano Hajime, Sudhir Krishnankutty, Saito Shigeru, Stone Gregg W, Fitzgerald Peter J
    Oct. 2008, AMERICAN JOURNAL OF CARDIOLOGY, 102(8A) (8A), 138I
    [Refereed]

  • Impact of Pre-procedural C-reactive Protein on Intravascular Ultrasound Parameters following Everolimus-eluting Stent Implantation: Results from the SPIRIT III Trial
    Daisaku Nakatani, Junya Ake, Masao Yamasaki, Takao Shimohama, Hiromasa Otake, Ichizo Tsujino, Bon-Kwon Koo, Katsuhisa Waseda, Hyeonsoo Chang, Ryota Sakurai, Paul G. Yock, Yasuhiro Honda, Wesley Pierson, Krishnankutty Sudhir, Peter J. Fitzgerald
    Oct. 2008, CIRCULATION, 118(18) (18), S1051 - S1051, English
    [Refereed]

  • Takahiro Sawada, Junya Shite, Hector M. Garcia-Garcia, Toshiro Shinke, Satoshi Watanabe, Hiromasa Otake, Daisuke Matsumoto, Yusuke Tanino, Daisuke Ogasawara, Hiroyuki Kawamori, Hiroki Kato, Naoki Miyoshi, Mitsuhiro Yokoyama, Patrick W. Serruys, Ken-ichi Hirata
    May 2008, EUROPEAN HEART JOURNAL, 29(9) (9), 1136 - 1146, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiromasa Otake, Junya Shite, Toshiro Shinke, Satoshi Watanabe, Yusuke Tanino, Daisuke Ogasawara, Takahiro Sawada, Ken-ichi Hirata, Mitsuhiro Yokoyama
    Jan. 2008, AMERICAN JOURNAL OF CARDIOLOGY, 101(1) (1), 1 - 7, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Toshiro Shinke, Junya Shite, Hideyuki Takaoka, Katsuya Hata, Nobutaka Inoue, Ryohei Yoshikawa, Hidenari Matsumoto, Hiroyuki Masai, Satoshi Watanabe, Tohru Ozawa, Hiromasa Otake, Daisuke Matsumoto, Ken-ichi Hirata, Mitsuhiro Yokoyama
    Oct. 2007, AMERICAN HEART JOURNAL, 154(4) (4), English
    [Refereed]
    Scientific journal

  • Daisuke Matsumoto, Junya Shite, Toshiro Shinke, Hiromasa Otake, Yusuke Tanino, Daisuke Ogasawara, Takahiro Sawada, Oscar Luis Paredes, Ken-ichi Hirata, Mitsuhiro Yokoyama
    Apr. 2007, EUROPEAN HEART JOURNAL, 28(8) (8), 961 - 967, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiromasa Otake, Junya Shite, Oscar Luis Paredes, Toshiro Shinke, Ryohei Yoshikawa, Yusuke Tanino, Satoshi Watanabe, Toru Ozawa, Daisuke Matsumoto, Daisuke Ogasawara, Mitsuhiro Yokoyama
    Jan. 2007, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 49(2) (2), 250 - 260, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Persistent malapposition after implantation of sirolimus-eluting stent into intramural coronary hematoma - Optical coherence tomography observations
    Takahiro Sawada, Junya Shite, Toshiro Shinke, Satoshi Watanabe, Hiromasa Otake, Daisuke Matsumoto, Yusuke Imuro, Daisuke Ogasawara, Oscal Luis Paredes, Mitsuhiro Yokoyama
    Nov. 2006, CIRCULATION JOURNAL, 70(11) (11), 1515 - 1519, English
    [Refereed]
    Scientific journal

  • Impedance cardiography for cardiac output estimation - Reliability of wrist-to-ankle electrode configuration
    Oscar Luis Paredes, Junya Shite, Toshiro Shinke, Satoshi Watanabe, Hiromasa Otake, Daisuke Matsumoto, Yusuke Imuro, Daisuke Ogasawara, Takahiro Sawada, Mitsuhiro Yokoyama
    Sep. 2006, CIRCULATION JOURNAL, 70(9) (9), 1164 - 1168, English
    [Refereed]
    Scientific journal

  • S Watanabe, J Shite, H Takaoka, T Shinke, Y Imuro, T Ozawa, H Otake, D Matsumoto, D Ogasawara, OL Paredes, M Yokoyama
    Apr. 2006, EUROPEAN HEART JOURNAL, 27(7) (7), 832 - 838, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • SHINKE, Toshiro, SHITE, Junya, 松本大典, 吉川糧平, 松本英成, 渡邊哲史, 小澤徹, 大竹寛雅, 伊室祐介, 小笠原大介, オスカル・ルイス, YOKOYAMA, Mitsuhiro
    【背景と目的】冠動脈ステント留置後遠隔期再狭窄には,拡張後のステント断面積,ステント外の残存プラーク量が影響するとされる.今回,血管内超音波(IVUS)ガイド下にbare metal Bx velocityステントの留置を行い,病変部動脈リモデリングとの関連を検討した.
    【方法】対象は,同ステントの留置前後に良好なIVUS画像が得られた62病変(53症例).経皮的冠動脈形成術(PCI)前に,IVUSにより病変部血管断面積(vessel area:VA)/平均対照部VA>1.0をポジティブリモデリング(PR)群(n=30),≦1.0をnon-PR群(n=32)とし,比較検討した.PCI前,ステント留置後の病変部のVA(mm2),内腔面積(lumenarea:LA)(mm2),プラーク面積率(%plaquearea:%PA=VA-LA/VA)を計測し,PCI前後,遠隔期(6±1カ月後)に定量的冠動脈造影(QCA)を行い,病変部最小血管径(MLD)(mm),径狭窄率(%DS),病変長(LL)(mm)を計測,遠隔期%DS>50%を再狭窄とした.PR群について,ステント拡張後残存%PAの中央値(47%)で2群に分け,再狭窄率を比較した.
    【結果】使用ステント径,長さ,最大拡張圧,最終バルーン径は両群間に差はなかった.PR群,non-PR群ともに,術後同等のステント断面積が得られたが,慢性期の内径損失がPR群で高い傾向にあり,再狭窄率が高かった(52%vs25%;p<0.05).PR群において残存%PAの少ない例(%PA:40.9±5.3%)と多い例(54.2±9.0%)の間に再狭窄率に差はなかった(46%vs42%).
    【結語】冠動脈病変部血管のポジティブリモデリングは,Bx velocityステント留置後の,遠隔期再狭窄に寄与すると考えられた.
    Japan Heart Foundation, Mar. 2006, 心臓, 38巻, 3号, pp.246-251(3) (3), 246 - 251, Japanese
    [Refereed]
    Scientific journal

  • Relationship between high sensitive c-reactive protein and coronary plaque component in patients with acute coronary syndrome: virtual histology TM study
    Takahiro Sawada, Junya Shite, Toshiro Shinke, Satoshi Watanabe, Hiromasa Otake, Daisuke Matsumoto, Yusuke Tanino, Daisuke Ogasawara, Oscal Luis Paredes, Mitsuhiro Yokoyama
    2006, Journal of Cardiology, 48(3) (3), 141 - 150, Japanese
    [Refereed]
    Scientific journal

  • SHINKE, Toshiro, SHITE, Junya, 小澤徹, 渡邉哲史, 大竹寛雅, 松本大典, オスカル・パレデス, 谷野祐介, 小笠原大介, 澤田隆弘, YOKOYAMA, Mitsuhiro, 木島洋一, HATA,Katsuya, 高岡秀幸
    Jan. 2006, 心臓, 38巻, 1号, pp.71-74, Japanese
    [Refereed]
    Scientific journal

  • Beneficial effects of human atrial natriuretic peptide on renal function in a patient with repeated coronary interventions: A case report
    Oscar Luis Paredes, Junya Shite, Toshiro Shinke, Yusuke Imuro, Ryouhei Yoshikawa, Satoshi Watanabe, Toru Ozawa, Hiromasa Otake, Daisuke Matsumoto, Daisuke Ogasawara, Mitsuhiro Yokoyama
    Oct. 2005, Journal of Cardiology, 46(4) (4), 161 - 164, English
    [Refereed]
    Scientific journal

  • 当院における急性肺塞栓症の治療経験,外科的塞栓摘出術の有用性
    吉川糧平, SHITE, Junya, SHINKE, Toshiro, KAWAI, Hiroya, 松本英成, 渡辺哲史, 正井博之, 小澤徹, 大竹寛雅, 松本大典, YOKOYAMA, Mitsuhiro, OKITA, Yutaka
    Jun. 2004, Therapeutic Research, 25巻, 6号, pp. 1214-1216, Japanese
    [Refereed]
    Scientific journal

■ MISC
  • Impact of Pericoronary Adipose Tissue Attenuation on Clinical Outcome after Percutaneous Coronary Intervention with Second-Generation Drug-Eluting Stent
    浪花祥太, 川森裕之, 鳥羽敬義, 廣正聖, 佐々木諭, 藤井寛之, 濱名智世, 大隅祐人, 山本哲也, 岩根成豪, 坂本優樹, 松濱考志, 福石悠太, 綱本浩志, 樋口功太郎, 岡本裕哉, 岩崎正道, 高谷具史, 山田愼一郎, 平田健一, 大竹寛雅
    2024, 日本循環器学会学術集会(Web), 88th

  • Successful transcatheter stent implantation for late thrombotic occlusion after BT shunt surgery
    上村航也, 福田旭伸, 大竹寛雅, 大隅祐人, 西原悠, 藤井寛之, 鳥羽敬義, 川森裕之, 城戸佐知子, 田中敏克, 近藤亜耶, 松久弘典, 高橋宏明, 岡田健次, 平田健一
    2023, 日本成人先天性心疾患学会雑誌(Web), 12(1) (1)

  • Diagnostic Accuracy of Nitroglycerin-free FFRCT-based Physiological Assessment in Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement
    佐々木諭, 大竹寛雅, 川森裕之, 鳥羽敬義, 竹重遼, 福山裕介, 柿崎俊介, 中村公一, 藤本大地, 藤井寛之, 濱名智世, 大隅祐人, 山本哲也, 藤岡知夫, 岩根成豪, 浪花祥太, 坂本優樹, 松濱考志, 福石悠太, 新家俊郎, 平田健一
    2023, 日本循環器学会学術集会(Web), 87th

  • がんの既往と第2世代ステント血栓症との関連~REAL-STレジストリ研究より~
    濱名智世, 大竹寛雅, 川森裕之, 鳥羽敬義, 廣正聖, 佐々木諭, 藤井寛之, 大隅祐人, 平田健一
    2023, 日本腫瘍循環器学会学術集会抄録集(Web), 6th

  • 日本人において血清トランス脂肪酸濃度の上昇は経皮的冠動脈インターベンション後の再血行再建術発生の独立したリスク因子となる
    尾下 寿彦, 杜 隆嗣, 篠原 正和, 森 健太, 入野 康宏, 長尾 学, 原 哲也, 大竹 寛雅, 石田 達郎, 平田 健一
    (一社)日本動脈硬化学会, Jul. 2019, 日本動脈硬化学会総会プログラム・抄録集, 51回, 2 - 3, Japanese

  • HDL機能性の新しい指標であるコレステロール取り込み能とコレステロール排出能の冠動脈プラーク特性に関連した比較(Comparison of Cholesterol Uptake Capacity, a Novel Indicator for HDL-functionality, and Cholesterol Efflux Capacity in Association with Coronary Plaque Properties)
    尾下 寿彦, 杜 隆嗣, 岡野 光真, 渡部 晃一, 西森 誠, 永野 雄一朗, 原田 周, 村上 克洋, 桐山 真利亜, 吉川 景子, 三輪 桂子, 小林 成美, 篠原 正和, 原 哲也, 入野 康宏, 大竹 寛雅, 石田 達郎, 平田 健一
    (一社)日本循環器学会, Mar. 2019, 日本循環器学会学術集会抄録集, 83回, PJ100 - 3, English

  • Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, vs. Cholesterol Efflux Capacity in Association With Coronary Plaque Lipid Burden.
    Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Kouichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Seimi Kobayashi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake, Tatsuro Ishida, Ken-ichi Hirata
    06 Nov. 2018, CIRCULATION, 138, English
    Summary international conference

  • The clinical impact of daily glucose fluctuation on cardiovascular events in patients with stable angina pectoris pretreated with lipid-lowering therapy
    Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Yuto Shinkura, Koji Kuroda, Yuichiro Nagano, Takayoshi Toba, Youichirou Sugizaki, Hiroyuki Onishi, Ken-ichi Hirata
    Oct. 2017, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B331 - B331, English
    Summary international conference

  • Coronary Risk Factors Associated with OCT Macrophage Images and their Response After CoCr Everolimus-Eluting Stent Implantation in Patients with Stable Coronary Artery Disease: Subanalysis of the MECHANISM-Elective study
    Yuya Taguchi, Tomonori Itoh, Hideto Oda, Yohei Uchimura, Kyosuke Kaneko, Tsubasa Sakamoto, Iwao Goto, Masafumi Sakuma, Masaru Ishida, Yoshihiro Morino, Daisuke Terashita, Hiromasa Otake, Toshiro Shinke
    Oct. 2017, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B286 - B286, English
    Summary international conference

  • High Wall Shear Stress was Strongly Associated with Plaque Vulnerability in Computational Fluid Dynamics with Combined Optical Coherence Tomography and Heartflow FFRCT Simulation
    Takayoshi Toba, Gilwoo Choi, Yuichiro Nagano, Hiroyuki Kawamori, Toshiro Shinke, Charles Taylor, Hiromasa Otake
    Oct. 2017, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B186 - B186, English
    Summary international conference

  • Different tissue morphology of in-stent restenosis in hemodialysis patient compared with non-hemodialysis patients: a prospective multicenter optical coherence tomography registry
    Yoshinori Nagasawa, Hiromasa Otake, Tomofumi Takaya, Masaru Kuroda, Junya Shite, Masahito Kawata, Daisuke Matsumoto, Daisuke Kamoi, Ken-ichi Hirata
    Oct. 2017, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B42 - B42, English
    Summary international conference

  • The combination of rosuvastatin (10mg) and eicosapentaenoic acid (1800mg) improved native coronary plaques > 5.7 years after stent implantation
    Youichirou Sugizaki, Hiromasa Otake, Toshiro Shinke, Hiroyuki Kawamori, Koji Kuroda, Takayoshi Toba, Yuto Shinkura, Yuichiro Nagano, Hiroyuki Yamamoto, Hiroyuki Onishi
    Oct. 2017, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B220 - B220, English
    Summary international conference

  • Vascular healing response to biodegradable-polymer sirolimus-eluting stent, UltimasterTM, in comparison with durable-polymer everolimus-eluting stent, XienceTM/PromusTM, assessed by optical coherence tomography and angioscopy at 10 months
    Amane Kozuki, Toshiro Shinke, Ryoji Nagoshi, Hiromasa Otake, Junya Shite
    Oct. 2017, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B96 - B96, English
    Summary international conference

  • 大動脈弁石灰化の密度は大動脈弁口面積に依存することなく大動脈弁狭窄の血行動態的重症度を予測する(Aortic Valve Calcification Density Predicts the Hemodynamic Severity of Aortic Stenosis Independently of Aortic Valve Area)
    鳥羽 敬義, 森 俊平, 田原 奈津子, 伊澤 有, 寺下 大輔, 松添 弘樹, 松本 賢亮, 田中 秀和, 大竹 寛雅, 藤原 征, 新家 俊郎, 西井 達矢, 河野 淳, 平田 健一
    (一社)日本循環器学会, Mar. 2017, 日本循環器学会学術集会抄録集, 81回, PJ - 386, English

  • Conformability and Wall Shear Stress Assessment Following Deployment of Resolute Integrity Zotarolimus-Eluting Stent and the XIENCE Xpedition Everolimus-Eluting Stent in Angulated Vessels: An Interim Analysis of the SHEAR-STENT Randomized Controlled Study
    Bill D. Gogas, Vishnu Koganti, Yasir H. Bouchi, David Molony, Wenjie Zeng, Olivia Y. Hung, Faten Sebaali, Emily L. Davis, Hee Su Lee, Elizabeth W. Thompson, Udit Joshi, Mansi Maini, Esha Singhal, Eun-Seok Shin, Goran Stankovic, Hiromasa Otake, Takashi Akasaka, Javier Escaned, Bon Kwon-Koo, Chang-Wook Nam, Alessandro Veneziani, Don P. Giddens, Spencer B. King, Habib Samady
    Feb. 2017, JACC-CARDIOVASCULAR INTERVENTIONS, 10(3) (3), S30 - S30, English
    Summary international conference

  • The Different Responses after 3-month Implantation of CoCr-EES in Patients with Acute Myocardial Infarction and Stable Coronary Artery Disease
    伊藤智範, 石田大, 寺下大輔, 大竹寛雅, 菊池達郎, 林孝俊, 鈴木孝英, 伊藤良明, 岡村誉之, 栗山根廣, 新家俊郎, 森野禎浩
    2017, 日本循環器学会学術集会(Web), 81st

  • Current status and future perspective of optical coherence tomography in the management of coronary artery disease
    鳥羽 敬義, 大竹 寛雅, 新家 俊郎
    医歯薬出版, 05 Nov. 2016, 医学のあゆみ, 259(6) (6), 631 - 637, Japanese

  • Efficacy of aggressive balloon pulmonary angioplasty on chronic thromboembolic pulmonary hypertension beyond normalized mean pulmonary arterial pressure
    Yuto Shinkura, Kazuhiko Nakayama, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Koji Kuroda, Natsuko Tahara, Yoshinori Nagasawa, Yuichiro Nagano, Hiroyuki Yamamoto, Yoshiro Tsukiyama, Kenichi Yanaka, Naoki Tamada, Hiromasa Otake, Toshiro Shinke, Noriaki Emoto, Ken-ichi Hirata
    Nov. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B37 - B37, English
    Summary international conference

  • Efficacy and safety of sequential hybrid therapy with pulmonary endarterectomy and additional balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension
    Kenichi Yanaka, Kazuhiko Nakayama, Toshiro Shinke, Hiromasa Otake, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Yuto Shinkura, Koji Kuroda, Kenzo Uzu, Natsuko Tahara, Yoshinori Nagasawa, Yuichiro Nagano, Naoki Tamada, Yoshiro Tsukiyama, Hiroyuki Yamamoto, Noriaki Emoto, Ken-ichi Hirata
    Nov. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B36 - B37, English
    Summary international conference

  • Impaired HDL uptake capacity which measure HDL functionality may associate with target lesion revascularization through provoking neoatherosclerosis formation after stent implantation
    Yuichiro Nagano, Hiromasa Otake, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Yasuhiro Irino, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Koji Kuroda, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Yoshinori Nagasawa, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Toshiro Shinke, Tatsuro Ishida, Ryuji Toh, Ken-Ichi Hirata
    Nov. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B136 - B136, English
    Summary international conference

  • Potent effect of prasugrel on acute phase resolution of intra-stent tissue after percutaneous intervention to acute coronary syndrome
    Yoshiro Tsukiyama, Amane Kozuki, Toshiro Shinke, Hiromasa Otake, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Koji Kuroda, Yuto Shinkura, Natsuko Tahara, Yoshinori Nagasawa, Yuichiro Nagano, Kenichi Yanaka, Hiroyuki Yamamoto, Junya Shite, Ken-ichi Hirata
    Nov. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B239 - B240, English
    Summary international conference

  • Early vascular responses to everolimus-eluting cobalt-chronium stent for the treatment of ST-elevation acute myocardial infarction: the results of the MECHANISM-AMI study 3-months OCT follow-up cohort
    Daisuke Terashita, Yoshihiro Morino, Hiromasa Otake, Tatsuo Kikuchi, Tetsuya Fusazaki, Nehiro Kuriyama, Takahide Suzuki, Toshiya Muramatsu, Kiyoshi Hibi, Hiroyuki Tanaka, Shozo Ishihara, Toru Kataoka, Takayuki Okamura, Takashi Morita, Yoritaka Otsuka, Takatoshi Hayashi, Kengo Tanabe, Toshiro Shinke, Ken-ichi Hirata
    Nov. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B227 - B227, English
    Summary international conference

  • Why does thin-cap fibroatheroma cluster in the proximal segment in left anterior coronary artery, but are evenly distributed throughout the entire right coronary artery? Results from computational fluid dynamics simulation by CT-FFR
    Takayoshi Toba, Gilwoo Choi, Kenzo Uzu, Toshiro Shinke, Bon-Kwon Koo, Charles Taylor, Hiromasa Otake
    Nov. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B243 - B243, English
    Summary international conference

  • Impact of daily glucose fluctuation on progression of luminal narrowing in stable coronary artery disease patients pretreated with lipid-lowering therapy
    H. Yamamoto, T. Shinke, H. Otake, T. Takaya, M. Kuroda, H. Takahashi, Y. Toba, D. Terashita, K. Kuroda, N. Tahara, K. Uzu, Y. Shinkura, Y. Nagasawa, K. Hirata
    Aug. 2016, EUROPEAN HEART JOURNAL, 37, 389 - 389, English
    Summary international conference

  • Early vascular responses to everolimus-eluting cobalt-chromium stent for the treatment of stable coronary artery disease: The results of MECHANISM-Elective 1 and 3 months OCT follow-up cohort
    T. Shinke, T. Itoh, T. Kikuchi, T. Morita, T. Inoue, J. Shite, Y. Morino, S. Sonoda, N. Kuriyama, H. Otake, T. Okamura, Y. Yasaka, A. Matsuura, K. Hibi, J. Furuya
    Aug. 2016, EUROPEAN HEART JOURNAL, 37, 387 - 387, English
    Summary international conference

  • EVALUATION OF LOCAL HEMODYNAMIC FORCES ACTING ON PLAQUE MAY HELP PREDICT PLAQUE VULNERABILITY: LESSONS FROM COMBINED ANALYSIS OF OPTICAL COHERENCE TOMOGRAPHY AND COMPUTATIONAL FLUID DYNAMICS SIMULATION
    Kenzo Uzu, Gilwoo Choi, Hyun Jin Kim, Arjun Roy, Trang Nguyen, Michiel Schaap, Leo Grady, Takayoshi Toba, Shumpei Mori, Tomofumi Takaya, Toshiro Shinke, Bon-Kwon Koo, Charles Taylor, Hiromasa Otake
    Apr. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 319 - 319, English
    Summary international conference

  • IMPACT OF PRECISION OF LUMEN BOUNDARY EXTRACTED FROM CORONARY CT ON FFRCT: VALIDATION WITH OCT
    Takayoshi Toba, Gilwoo Choi, Kenzo Uzu, Hyun Jin Kim, Arjun Roy, Tran Nguyen, Michiel Schaap, Leo Grady, Shumpei Mori, Tomofumi Takaya, Toshiro Shinke, Charles Taylor, Hiromasa Otake
    Apr. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 315 - 315, English
    Summary international conference

  • THE IMPACT OF SERUM TRANS FATTY ACIDS CONCENTRATION ON PLAQUE VULNERABILITY IN PATIENTS WITH CORONARY ARTERY DISEASE UNDER MANAGEMENT OF CONVENTIONAL RISK FACTORS: ASSESSMENT VIA OPTICAL COHERENCE TOMOGRAPHY
    Yoshinori Nagasawa, Toshiro Shinke, Ryuji Toh, Hiromasa Otake, Tomofumi Takaya, Takayoshi Toba, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Daiji Kashiwagi, Koji Kuroda, Yuto Shinkura, Natsuko Tahara, Hiroyuki Yamamoto, Yoshiro Tsukiyama, Kenichi Yanaka, Yuichiro Nagano, Tatsuro Ishida, Ken-Ichi Hirata
    Apr. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 361 - 361, English
    Summary international conference

  • INTRA-STENT THROMBUS FORMATION FOLLOWING BIOLIMUS A-9 ELUTING STENT IMPLANTATION IN PATIENTS WITH SHORTER AND PROLONGED DUAL ANTI-PLATELET THERAPY: OPTICAL COHERENCE TOMOGRAPHY SUB-STUDY OF NIPPON TRIAL
    Koji Kuroda, Masato Nakamura, Hiroyoshi Yokoi, Shinsuke Nanto, Kazuaki Mitsudo, Shigeru Saito, Junya Ako, Raisuke Iijima, Toshiro Shinke, Hiromasa Otake, Tomofumi Takaya, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Yuto Shinkura, Daiji Kashiwagi, Natsuko Tahara, Yoshinori Nagasawa, Ken-Ichi Hirata
    Apr. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 365 - 365, English
    Summary international conference

  • IMPACT OF WALL SHEAR STRESS AND AXIAL PLAQUE STRESS ON CORONARY PLAQUE INITIATION AND PROGRESSION
    Takayoshi Toba, Gilwoo Choi, Hyun Jin Kim, Arjun Roy, Tran Nguyen, Michiel Schaap, Leo Grady, Kenzo Uzu, Shumpei Mori, Tomofumi Takaya, Toshiro Shinke, Bon-Kwon Koo, Charles Taylor, Hiromasa Otake
    Apr. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 1755 - 1755, English
    Summary international conference

  • INVESTIGATION OF HEMODYNAMIC CHANGES DURING BALLOON OCCLUSION TEST FOR PERCUTANEOUS ATRIAL SEPTAL DEFECT CLOSURE
    Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Tomofumi Takaya, Masaru Kuroda, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Koji Kuroda, Natsuko Tahara, Daiji Kashiwagi, Yoshinori Nagasawa, Yoshiro Tsukiyama, Kenichi Yanaka, Ken-Ichi Hirata
    Apr. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 935 - 935, English
    Summary international conference

  • CORRELATION OF WALL SHEAR STRESS AND AXIAL PLAQUE STRESS BETWEEN MODELS DERIVED FROM CT AND OCT DATA
    Gilwoo Choi, Kenzo Uzu, Takayoshi Toba, Hyun Jin Kim, Arjun Roy, Tran Nguyen, Leo Grady, Tomofumi Takaya, Shumpei Mori, Toshiro Shinke, Bon Kwon Koo, Charles Taylor, Hiromasa Otake
    Apr. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 1772 - 1772, English
    Summary international conference

  • 脂質降下療法を受けている安定狭心症における冠動脈病変の進行に対して血糖変動が及ぼす影響についての検討
    山本裕之, 新家俊郎, 大竹寛雅, 高谷具史, 鳥羽敬義, 黒田優, 高橋八大, 寺下大輔, 宇津賢三, 黒田浩史, 田原奈津子, 永野雄一朗, 築山義朗, 長澤圭典, 谷仲謙一, 新倉悠人, 平田健一
    2016, 日本循環器学会近畿地方会(Web), 122nd

  • 【冠動脈イメージングを極める-侵襲的から非侵襲的方法-】 冠動脈病変を治療する イメージングガイドインターベンションを極める OCTガイドPCI
    新家俊郎, 大竹寛雅, Hirata Ken-ichi
    Nov. 2015, Coronary Intervention, 11(6号) (6号), 96 - 102, Japanese
    Introduction commerce magazine

  • Early vascular responses to everolimus-eluting cobalt-chromium stent for the treatment of stable coronary artery disease: The results of MECHANISM-Elective 1-month OCT follow-up cohort
    Toshiro Shinke, Hiromasa Otake, Daisuke Terashita, Tetsuya Fusazaki, Tatsuo Kikuchi, Takayuki Okamura, Takashi Morita, Takahiro Sawada, Akira Matsuura, Yoshinori Yasaka, Amane Kozuki, Junya Shite, Toru Kataoka, Kiyoshi Hibi, Shozo Ishihara, Takashi Akasaka, Takashi Kubo, Shinjo Sonoda, Jungo Furuya, Teppei Sugaya, Yoshisato Shibata, Nehiro Kuriyama, Daisuke Matsumoto, Yoritaka Otsuka, Yoshihiro Morino
    Oct. 2015, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B21 - B22, English
    Summary international conference

  • Optical coherence tomographic evaluation of very acute change of coronary stent implanted in acute coronary syndrome patients
    Yoshiro Tsukiyama, Amane Kozuki, Toshiro Shinke, Hiromasa Otake, Yoichi Kijima, Tomoya Masano, Ryoji Nagoshi, Kimitake Imamura, Hiroyuki Shibata, Kenichi Yanaka, Shinsuke Nakano, Junya Shite, Ken-ichi Hirata
    Oct. 2015, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B140 - B141, English
    Summary international conference

  • The Impact of Plaque Morphology and Malapposition Area on Late Phase Stent Malapposition: Insight From Optimal Coherence Tomography Sub-study in PRASFIT Elective
    Kenzo Uzu, Toshiro Shinke, Hiromasa Otake, Tomofumi Takaya, Hiroto Kinutani, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Ken-ichi Hirata, Shigeru Saito, Masato Nakamura, Junya Shite, Takashi Akasaka
    Oct. 2015, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B19 - B20, English
    Summary international conference

  • Accuracy of lumen boundary extracted from coronary CTA for calcified and noncalcified plaques assessed using OCT data
    Gilwoo Choi, Kenzo Uzu, Takayoshi Toba, Shumpei Mori, Tomofumi Takaya, Toshiro Shinke, Arjun Roy, Tran Nguyen, Sophie Khem, Charles A. Taylor, Hiromasa Otake
    Oct. 2015, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B134 - B134, English
    Summary international conference

  • Impact of Daily Glucose Fluctuation on Vessel Healing after 2nd Generation Drug-eluting Stent Implantation Assessed by Continuous Glucose Monitoring and Optical Coherence Tomography
    Masaru Kuroda, Toshiro Shinke, Hiromasa Otake, Tomofumi Takaya, Daiji Kashiwagi, Yuto Shinkura, Natsuko Tahara, Hiroto Kinutani, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Koji Kuroda, Yoshinori Nagasawa, Yushi Hirota, Kazuhiko Sakaguchi, Ken-ichi Hirata
    Oct. 2015, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B138 - B138, English
    Summary international conference

  • Early vascular responses to everolimus-eluting cobalt-chromium stent for the treatment of ST-elevation acute myocardial infarction: the results of the MECHANISM-AMI Study 2-week OCT follow-up cohort
    Yoshihiro Morino, Daisuke Terashita, Hiromasa Otake, Tatsuo Kikuchi, Tetsuya Fusazaki, Nehiro Kuriyama, Takahide Suzuki, Toshiya Muramatsu, Kiyoshi Hibi, Hiroyuki Tanaka, Shozo Ishihara, Toru Kataoka, Takayuki Okamura, Takashi Morita, Yoritaka Otsuka, Takatoshi Hayashi, Kengo Tanabe, Toshiro Shinke
    Oct. 2015, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B142 - B142, English
    Summary international conference

  • Combined use of intravascular ultrasound and optical coherence tomography during percutaneous coronary intervention may reduce target lesion revascularization after percutaneous coronary intervention
    Daiji Kashiwagi, Hiromasa Otake, Toshiro Shinke, Tomofumi Takaya, Hiroto Kinutani, Takayoshi Toba, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Koji Kuroda, Yuto Shinkura, Natsuko Tahara, Yoshinori Nagasawa, Ken-ichi Hirata
    Oct. 2015, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B146 - B146, English
    Summary international conference

  • MECHANISM OF LUMINAL WIDENING AND THE CORRECTION OF PLAQUE- AND CARINA-SHIFT AT SIDE BRANCH OSTIUM BY KISSING BALLOON INFLATION FOR CORONARY BIFURCATION LESIONS: VOLUMETRIC INTRAVASCULAR ULTRASOUND ANALYSIS
    Masahiro Yamawaki, Murasato Yoshinobu, Toshiro Shinke, Kenichi Fujii, Hiromasa Otake, Shinichiro Yamada, Yoshihiro Takeda, Yoshihisa Kinoshita
    Mar. 2015, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65(10) (10), A1737 - A1737, English
    Summary international conference

  • IMPACT OF DIABETES MELLITUS ON VESSEL GEOMETRY AND THE RESPONSE TO FINAL KISSING INFLATION FOLLOWING SINGLE STENTING FOR CORONARY BIFURCATION: ANALYSIS OF VOLUMETRIC INTRAVASCULAR ULTRASOUND AND OPTICAL COHERENCE TOMOGRAPY
    Masahiro Yamawaki, Yoshinobu Murasato, Daisuke Terashita, Toshiro Shinke, Hiromasa Otake, Kenichi Fujii, Yoshihiro Takeda, Shin-Ichiro Yamada, Yoshihisa Kinoshita
    Mar. 2015, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65(10) (10), A1838 - A1838, English
    Summary international conference

  • ASSOCIATION BETWEEN DAILY GLUCOSE FLUCTUATION AND CORONARY PLAQUE PROPERTIES IN PATIENTS RECEIVING LIPID-LOWERING THERAPY ASSESSED BY CONTINUOUS GLUCOSE MONITORING AND OPTICAL COHERENCE TOMOGRAPHY: A PROSPECTIVE OBSERVATIONAL STUDY
    Masaru Kuroda, Toshro Shinke, Kazuhiko Sakaguchi, Hiromasa Otake, Tomofumi Takaya, Yushi Hirota, Tsuyoshi Osue, Hiroto Kinutani, Akihide Konishi, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Yuto Shinkura, Natsuko Tahara, Koji Kuroda, Daiji Kashiwagi, Keisuke Nagasawa, Ken-ichi Hirata
    Mar. 2015, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65(10) (10), A1851 - A1851, English
    Summary international conference

  • BENEFICIAL EFFECT OF PLATELET INHIBITION AGAINST PERI-PROCEDURAL MYOCARDIAL INFARCTION DUE TO INTRA-STENT THROMBUS PENETRATION: OPTICAL COHERENCE TOMOGRAPHY SUB-ANALYSIS IN PRASFIT ELECTIVE
    Kenzo Uzu, Toshiro Shinke, Hiromasa Otake, Tomofumi Takaya, Tsuyoshi Osue, Masamichi Iwasaki, Akihide Konishi, Hiroto Kinutani, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Ken-ichi Hirata, Shigeru Saito, Masato Nakamura, Junya Shite, Takashi Akasaka
    Mar. 2015, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65(10) (10), A1939 - A1939, English
    Summary international conference

  • Either balloon pulmonary angioplasty or surgical pulmonary endarterectomy can cover most of patients with chronic thromboembolic pulmonary hypertension as treatment option
    Y. Taniguchi, T. Shinke, H. Kinutani, K. Miyagawa, K. Nakayama, T. Takaya, H. Otake, N. Emoto, K. Hirata
    Sep. 2014, EUROPEAN HEART JOURNAL, 35, 208 - 208, English
    Summary international conference

  • Serial Optical Coherence Tomography Evaluation 6-, 12-and 24-month Follow-up after Nobori Biolimus A9-eluting Stent Implantation
    Akihide Konishi, Toshiro Shinke, Hiromasa Otake, Tomofumi Takaya, Masayuki Nakagawa, Takumi Inoue, Tsuyoshi Ohsue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Hiroto Kinutani, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita
    Sep. 2014, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 64(11) (11), B115 - B116, English
    Summary international conference

  • 新時代を迎えた冠動脈インターベンション 10 OCT/OFDIガイドPCIの現状と展望
    高谷具史, 大竹寛雅, 新家俊郎
    09 Aug. 2014, Heart View, 18(8) (8), 852 - 860, Japanese

  • モダリティーを駆使してイメージング巧者になる Tips & Tricks FD-OCTの臨床活用術
    谷岡 怜, 高谷 具史, 大竹 寛雅, 新家 俊郎, Hirata Ken-ichi
    Jul. 2014, 日本心血管インターベンション治療学会抄録集 23回, CPD4 - 3, Japanese
    Meeting report

  • LONG-TERM CLINICAL IMPACT OF THIN-CAP FIBROATHEROMA ASSESSED BY OPTICAL COHERENCE TOMOGRAPHY AND VIRTUAL HISTOLOGY INTRAVASCULAR ULTRASOUND ANALYSIS
    Daisuke Terashita, Hiromasa Otake, Toshiro Shinke, Tomofumi Takaya, Ryo Nishio, Masayuki Nakagawa, Yu Taniguchi, Hiroto Kinutani, Tsuyoshi Ohsue, Masamichi Iwasaki, Akihide Konishi, Masaru Kuroda, Hachidai Takahashi
    Apr. 2014, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 63(12) (12), A1797 - A1797, English
    Summary international conference

  • IMPACT OF DAILY GLUCOSE FLUCTUATION ON CORONARY PLAQUE VULNERABILITY IN PATIENTS PRETREATED WITH LIPID LOWERING THERAPY
    Masaru Kuroda, Toshiro Shinke, Kazuhiko Sakaguchi, Hiromasa Otake, Yushi Hirota, Tomofumi Takaya, Masayuki Nakagawa, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Hiroto Kinutani, Akihide Konishi, Hachidai Takahashi, Daisuke Terashita, Kenichi Hirata
    Apr. 2014, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 63(12) (12), A1795 - A1795, English
    Summary international conference

  • ASSESSMENT OF PLAQUE CHARACTERIZATION ON CORONARY CT ANGIOGRAPHY FOR IDENTIFICATION OF HIGH-RISK CORONARY ARTERY LESIONS: A DIRECT COMPARISON TO OPTICAL COHERENCE TOMOGRAPHY
    Ryo Nakazato, Hiromasa Otake, Akihide Konishi, Masamichi Iwasaki, Bon-Kwon Koo, Toshiro Shinke, Ken-ichi Hirata, Jonathan Leipsic, Daniel Berman
    Apr. 2014, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 63(12) (12), A1161 - A1161, English
    Summary international conference

  • INTRAVASCULAR ULTRASOUND ASSESSMENT OF SIDE BRANCH OSTIUM AFTER A CROSSOVER STENTING WITH FINAL KISSING BALLOON INFLATION IN CORONARY BIFURCATION LESION
    Masahiro Yamawaki, Yoshinobu Murasato, Kenichi Fujii, Shinke Toshiro, Hiromasa Otake, Yoshihiro Takeda, Shinichiro Yamada, Yoshihisa Shimada, Takehiro Yamashita, Kazuhiko Yumoto, Yoshihisa Kinoshita
    Apr. 2014, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 63(12) (12), A1913 - A1913, English
    Summary international conference

  • 脂質代謝異常症への多角的アプローチ エベロリムス溶出性ステント留置後の血管治癒過程に関する検討
    大竹 寛雅, 新家 敏郎, Hirata Ken-ichi
    Apr. 2014, The Lipid, 25(2号) (2号), 170 - 174, Japanese
    [Invited]
    Introduction commerce magazine

  • Impact of Immediate Vessel Reactions to Stent Deployment on Periprocedural Troponin Leakage and Mid-term Vascular Healing: Serial Optical Coherence Tomography Study after Everolimus-eluting Stent Implantation
    Masamichi Iwasaki, Toshiro Shinke, Hiromasa Otake, Tomofumi Takaya, Masayuki Nakagawa, Tsuyoshi Ohsue, Yu Taniguchi, Hiroto Kinutani, Akihide Konishi, Ryo Nishio, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Ken-ichi Hirata
    Oct. 2013, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 62(18) (18), B178 - B178, English
    Summary international conference

  • The Impact of Atherogenic Neointima on Long-term Clinical Outcomes: An Observational Study from the Optical Coherence Tomography Registry
    Masaru Kuroda, Toshiro Shinke, Hiromasa Otake, Tomofumi Takaya, Masayuki Nakagawa, Hirotoshi Hariki, Tsuyoshi Ohsue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Akihide Konishi, Hiroto Kinutani, Hachidai Takahashi, Daisuke Terashita, Ken-ichi Hirata
    Oct. 2013, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 62(18) (18), B140 - B140, English
    Summary international conference

  • 透析患者におけるカテーテル治療戦略 透析患者における薬剤溶出性ステント留置後のoptical coherence tomography所見 透析前後における血小板凝集能との関連について
    小西 明英, Shinke Toshiro, 大竹 寛雅, 中川 雅之, 井上 琢海, 張木 洋寿, 大末 剛史, 谷口 悠, 岩崎 正道, 西尾 亮, 平沼 永敏, 絹谷 洋人, 黒田 優, 志手 淳也, Hirata Ken-ichi
    Sep. 2013, 日本心臓病学会誌, 8(Suppl.I) (Suppl.I), 161, Japanese
    Meeting report

  • Efficacy and safety of balloon pulmonary angioplasty for inoperable patients with peripheral type chronic thromboembolic pulmonary hypertension
    Y. Taniguchi, T. Shinke, H. Kinutani, H. Otake, N. Emoto, K. Hirata
    Aug. 2013, EUROPEAN HEART JOURNAL, 34, 155 - 155, English
    Summary international conference

  • Hemodynamic improvement through beneficial vessel reaction following balloon pulmonary angioplasty for distal-type chronic thromboembolic pulmonary hypertension
    H. Kinutani, T. Shinke, H. Otake, Y. Taniguchi, N. Emoto, K. Nakayama, K. Hirata
    Aug. 2013, EUROPEAN HEART JOURNAL, 34, 50 - 50, English
    Summary international conference

  • DIFFERENT TIME COURSE OF NEOATHEROSCLEROSIS DEVELOPMENT IN BARE METAL STENTS, SIROLIMUS-ELUTING STENTS AND PACLITAXEL-ELUTING STENTS
    Hirotoshi Hariki, Toshiro Shinke, Hiromasa Otake, Masayuki Nakagawa, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Hiranuma Noritoshi, Hiroto Kinutani, Akihide Konishi, Ken-ichi Hirata
    Mar. 2013, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 61(10) (10), E1673 - E1673, English
    Summary international conference

  • Efficacy and Safety of Balloon Pulmonary Angioplasty for Peripheral Type Chronic Thromboembolic Pulmonary Hypertension
    Yu Taniguchi, Noriaki Emoto, Hiroto Kinutani, Hiromasa Otake, Toshiro Shinke, Junya Shite, Kenichi Hirata
    Oct. 2012, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 60(17) (17), B220 - B220, English
    Summary international conference

  • Multi Center, Prospective, Randomized, Single Blind, Consecutive Enrollment Evaluation Of Elixir DESyneTM Novolimus-Eluting Coronary Stent System With Durable Polymer To Endeavor Zotarolimus-Eluting Coronary Stent System: 3-Year Clinical and 9-Month Angiographic And IVUS Results: EXCELLA II Study
    Stefan Verheye, Christophe Dubois, Karl-Eugen Hauptmann, John Ormiston, James Stewart, Joachim Schofer, Karl Stangl, Bernhard Witzenbichler, Marcus Wiemer, Emanuele Barbato, Peter Fitzgerald, Hiromasa Otake, Patrick W. Serruys
    Oct. 2012, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 60(17) (17), B191 - B191, English
    Summary international conference

  • Temporal Course of Vessel Healing after Everolimus-eluting Stent Implantation
    Hiromasa Otake, Hirotoshi Hariki, Noritoshi Hiranuma, Ken-ichi Hirata, Takumi Inoue, Masamichi Iwasaki, Hiroto Kinutani, Akihide Konishi, Masayuki Nakagawa, Toshiro Shinke, Junya Shite, Yu Taniguchi
    Oct. 2012, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 60(17) (17), B83 - B83, English
    Summary international conference

  • Beneficial Vascular Remodeling and Hemodynamic Improvement following Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension
    Hiroto Kinutani, Noriaki Emoto, Yu Taniguchi, Hiromasa Otake, Toshiro Shinke, Junya Shite, Kenichi Hirata
    Oct. 2012, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 60(17) (17), B220 - B221, English
    Summary international conference

  • Relationship between optical coherence tomography (OCT), intravascular ultrasound tomography (IVUS) and pressure-derived fractional flow reserve
    T. Osue, J. Shite, T. Shinke, H. Otake, K. Hirata
    Aug. 2012, EUROPEAN HEART JOURNAL, 33, 708 - 709, English
    Summary international conference

  • Paraoxonase-1 (PON1) activity is associated with clopidogrel response and intra-stent thrombus after drug-eluting stent implantation in the CYP2C19 loss-of-function polymorphism carriers
    R. Nishio, T. Shinke, H. Otake, M. Nakagawa, R. Nagoshi, A. Kozuki, M. Iwasaki, A. Konishi, J. Shite, K. Hirata
    Aug. 2012, EUROPEAN HEART JOURNAL, 33, 307 - 307, English
    Summary international conference

  • Impact of Cytochrome P450 2C19 loss-of-function polymorphism on intra-stent thrombus after sirolimus- and everolimus-eluting stent implantation assessed by angioscopy and optical coherence tomography
    M. Iwasaki, J. Shite, T. Shinke, H. Otake, M. Nakagawa, R. Nagoshi, H. Hariki, A. Kouzuki, T. Inoue, K. Hirata
    Aug. 2012, EUROPEAN HEART JOURNAL, 33, 1005 - 1005, English
    Summary international conference

  • 心血管インターベンションのコツとピットフォール 一流術者のココが知りたい OCTを日常のPCIに活かす
    Shinke Toshiro, 大竹 寛雅, 志手 淳也
    メディカ出版, Aug. 2012, CIRCULATION Up-to-Date, 7(4号) (4号), 387 - 393, Japanese
    Introduction commerce magazine

  • 志手 淳也, Shinke Toshiro, 大竹 寛雅
    医学書院, Jul. 2012, 呼吸と循環, 60(7号) (7号), 749 - 757, Japanese
    Introduction scientific journal

  • クロピドグレルにラベプラゾールを併用した薬剤溶出性ステント留置後患者におけるステント内血栓の検討 CYP2C19機能欠失型遺伝子多型の有無別にみたラベプラゾールの影響
    西尾 亮, Shinke Toshiro, 大竹 寛雅, 志手 淳也, 平田 健一
    Apr. 2012, 新薬と臨牀, 61(4号) (4号), 780 - 788, Japanese
    [Refereed]
    Introduction commerce magazine

  • A Case of Late Stent Thrombosis due to Delayed Arterial Healing after Bare Metal Stent Implantation to Acute Coronary Syndrome
    KONISHI Akihide, SHINKE Toshiro, OTAKE Hiromasa, SHITE Junya, HIRATA Kenichi, KONISHI Hiroki, KOBAYASHI Noriyasu, SENO Tadashi, ABE Hiroaki, FUJII Takashi
    日本心血管インターベンション治療学会, 15 Mar. 2012, 日本心血管インターベンション治療学会誌 = Cardiovascular intervention and therapeutics, 4(1) (1), 53 - 57, Japanese

  • SERIAL OCT AND HISTOPATHOLOGY ANALYSIS FOLLOWING 1ST AND NEW GENERATION DRUG ELUTING STENTS IMPLANTATION IN SWINE CORONARY ARTERY
    Hiranuma Noritoshi, Toshiro Shinke, Gaku Nakazawa, Hiromasa Otake, Matsumoto Daisuke, Takeshi Ijichi, Ohsue Tsuyoshi, Junya Shite, Ken-ichi Hirata
    Mar. 2012, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E219 - E219, English
    Summary international conference

  • DETAILED INVESTIGATION OF VASCULAR RESPONSE BETWEEN PATIENTS WITH OR WITHOUT DIABETES MELLITUS AFTER EVEROLIMUS-ELUTING STENT IMPLANTATION; OPTICAL COHERENCE TOMOGRAPHY STUDY
    Masamichi Iwasaki, Hiromasa Otake, Toshiro Shinke, Junya Shite, Ken-ichi Hirata
    Mar. 2012, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E1529 - E1529, English
    Summary international conference

  • THE IMPACT OF MID-TERM OCT FINDINGS ON LONG-TERM CLINICAL EVENTS AFTER DRUG-ELUTING STENTS IMPLANTATION
    Hiromasa Otake, Toshiro Shinke, Junya Shite, Ken-ichi Hirata
    Mar. 2012, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E120 - E120, English
    Summary international conference

  • OPTICAL COHERENCE TOMOGRAPHY ASSESSMENT OF HISTOPATHOLOGY AFTER 1ST AND 2ND GENERATION DRUG-ELUTING STENT IMPLANT IN PIG CORONARY MODEL
    Hiranuma Noritoshi, Toshiro Shinke, Gaku Nakazawa, Hiromasa Otake, Daisuke Matsumoto, Takeshi Ijichi, Tsuyoshi Osue, Junya Shite, Ken-ichi Hirata
    Mar. 2012, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E221 - E221, English
    Summary international conference

  • COMPARISONS OF SAFETY PROFILE BETWEEN DURABLE AND BIODEGRADABLE POLYMER BASED DRUG ELUTING STENTS IN PORCINE CORONARY ARTERY MODEL
    Takeshi Ijichi, Gaku Nakazawa, Toshiro Shinke, Daisuke Matsumoto, Hiromasa Otake, Sho Torii, Ayako Yoshikawa, Junya Shite, Yuji Ikari
    Mar. 2012, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E315 - E315, English
    Summary international conference

  • THE IMPACT OF PARAOXONASE 1 ACTIVITY ON THE INCIDENCE OF INTRA STENT THROMBUS AFTER DRUG ELUTING STENT IMPLANTATION IN THE JAPANESE CYP2C19 LOSS OF FUNCTION POLYMORPHISM CARRIERS
    Ryo Nishio, Toshiro Shinke, Hiromasa Otake, Junya Shite, Ken-ichi Hirata
    Mar. 2012, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E259 - E259, English
    Summary international conference

  • NEOINTIMAL COVERAGE OF JAILED STRUT FOLLOWING SINGLE STENTING TO BIFURCATION: OPTICAL COHERENCE TOMOGRAPHY ASSESSMENT FOR 3 TYPES OF DRUG-ELUTING STENTS
    Hirotoshi Hariki, Toshiro Shinke, Hiromasa Otake, Junya Shite, Ken-ichi Hirata
    Mar. 2012, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E89 - E89, English
    Summary international conference

  • トルバプタンが心不全の改善に有効であったミオパチーに伴う拡張型心筋症の1例
    濱田佳奈, 粟野宏之, 李知子, 中川卓, 八木麻理子, 張木洋寿, 名越良治, 大竹寛雅, 平田健一, 竹島泰弘
    (公社)日本小児科学会, 01 Dec. 2011, 日本小児科学会雑誌, 115(12) (12), 1945 - 1945, Japanese

  • Uniform Vessel Healing after Everolimus-eluting Stent implantation: Detailed Comparison with Paclitaxel-eluting Stent by Optical Coherence Tomography
    Tsuyoshi Osue, Junya Shite, Toshirou Shinke, Hiromasa Otake, Masayuki Nakagawa, Ryouji Nagoshi, Takumi Inoue, Amane Kozuki, Hirotoshi Hariki, Masamichi Iwasaki, Yu Taniguchi, Hirota Kinutani, Akihide Konishi, Ryo Nishio, Noritoshi Hiranuma, Ken-ichi Hiratam
    Nov. 2011, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58(20) (20), B180 - B180, English
    Summary international conference

  • Comparison of Angioscope and Optical Coherence Tomography findings for the Assessment of Intra-stent Thrombus and Neointima at 8 months After Sirolimus-Eluting Stent Implantation
    Takumi Inoue, Toshiro Shinke, Junya Shite, Hiromasa Otake, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Tsuyoshi Ohsue, Ryo Nishio, Yu Taniguchi, Noritoshi Hiranuma, Masamichi Iwasaki, Akihide Konishi
    Nov. 2011, CIRCULATION, 124(21) (21), English
    Summary international conference

  • Elevated Pre-procedural High-sensitive CRP Levels are Associated with Uneven Vessel Healing after Paclitaxel-eluting Stents Implantation in Patients with Stable Angina
    Hiromasa Otake, Junya Shite, Toshiro Shinke, Ken-ichi Hirata
    Nov. 2011, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58(20) (20), B72 - B72, English
    Summary international conference

  • In-vivo Assessment of Neoatherosclerosis after Sirolimus-eluting Stent implantation: Comparisons of Serial Optical Coherence Tomography Findings between Early and Late Follow-up
    Amane Kozuki, Junya Shite, Toshiro Shinke, Hiromasa Otake, Masayuki Nakagawa, Ryoji Nagoshi, Takum Inoue, Tsuyoshi Osue, Hirotoshi Hariki, Masamichi Iwasaki, Yu Taniguchi, Hiroto Kinutani, Akihide Konishi, Ryo Nishio, Noritoshi Hiranuma, Ken-ichi Hirata
    Nov. 2011, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58(20) (20), B181 - B181, English
    Summary international conference

  • Impact of Stent Platform of Paclitaxel-eluting Stents: Detailed Assessment of Neointimal Distribution by Optical Coherence Tomography
    Hiromasa Otake, Toshiro Shinke, Junya Shite, Masayuki Nakagawa, Ryoji Nagoshi, Tsuyoshi Osue, Ken-ichi Hirata
    Nov. 2011, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58(20) (20), B169 - B169, English
    Summary international conference

  • The impact of paraoxonase-1 activity on the incidence of intra-stent thrombus after drug-eluting stent implantation in the Japanese CYP2C19*2 carriers receiving clopidogrel
    Ryo Nishio, Junya Shite, Toshiro Shinke, Hiromasa Otake, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Yoko Haraguchi, Tatsuro Ishida
    Nov. 2011, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58(20) (20), B49 - B49, English
    Summary international conference

  • Qualitative and quantitative assessment of DES restenosis by IVUS and OCT.
    OTAKE HIROMASA
    日本臨床社, Sep. 2011, Nihon Rinsho., 69, 350 - 354, Japanese
    [Refereed]
    Introduction scientific journal

  • Current evidence about lipid-lowering therapy and coronary plaque.
    OTAKE HIROMASA
    日本臨床社, Sep. 2011, Nihon Rinsho., 69, 95 - 102, Japanese
    [Refereed]
    Introduction scientific journal

  • Natural consequence of stent malapposition tissue prolapse, thrombus and stent edge dissection assessed by optical coherence tomography
    H. Kawamori, J. Shite, T. Shinke, H. Otake, D. Matumoto, M. Nakagawa, Y. Nagoshi, A. Kozuki, H. Hariki, T. Inoue
    Aug. 2011, EUROPEAN HEART JOURNAL, 32, 853 - 854, English
    Summary international conference

  • VESSEL RESPONSE TO THE NOVEL POLYMER-FREE BIOFREEDOM STENT VERSUS CONVENTIONAL DURABLE POLYMER COATING STENT: SHORT- AND MID-TERM INTRAVASCULAR ULTRASOUND RESULTS FROM THE BIOFREEDOM FIRST-IN-MAN TRIAL
    Kenji Sakata, Byeong-Keuk Kim, Hiromasa Otake, Katsuhisa Waseda, Gerhard C. Schuler, Karl E. Hauptmann, Joachim Schofer, Paul G. Yock, Yasuhiro Honda, Eberhard Grube, Peter J. Fitzgerald
    Apr. 2011, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1758 - E1758, English
    Summary international conference

  • A NOVEL RADIOFREQUENCY SIGNAL ANALYSIS FOR CORONARY PLAQUE CHARACTERIZATION AT CULPRIT LESION USING IMAPTM: HOW CAN WE USE THE NEW PARAMETER: CONFIDENCE LEVEL?
    Amane Kozuki, Junya Shite, Toshiro Shinke, Hiromasa Otake, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Hirotoshi Hiranuma, Ryo Nishio, Ken-ichi Hirata
    Apr. 2011, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1860 - E1860, English
    Summary international conference

  • NATURAL CONSEQUENCE OF STENT MALAPOSITION ASSESSED BY OPTICAL COHERENCE TOMOGRAPHY
    Hiroyuki Kawamori, Junya Shite, Toshiro Shinke, Hiromasa Otake, Daisuke Matumoto, Masayuki Nakagawa, Yoshiharu Nagoshi, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Ohsue, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Ken-ichi Hirata
    Apr. 2011, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1744 - E1744, English
    Summary international conference

  • IMPACT OF CYTOCHROME P450 2C19*2 POLYMORPHISM ON THE TARGET LESION OUTCOME AFTER DRUG-ELUTING STENT IMPLANTATION IN JAPANESE PATIENTS RECEIVING CLOPIDOGREL.
    Ryo Nisho, Toshiro Shinke, Junya Shite, Takahiro Sawada, Ryuji Toh, Yoko Haraguchi, Hiromasa Otake, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Yu Taniguchi, Noritoshi Hiranuma, Ken-ichi Hirata
    Apr. 2011, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1299 - E1299, English
    Summary international conference

  • INFLUENCE OF PROTON PUMP INHIBITORS (PPIS) ON THE FORMATION OF INTRA-STENT THROMBUS IN JAPANESE PATIENTS RECEIVING CLOPIDOGREL WITH OR WITHOUT CYTOCHROME P450 2C19*2 POLYMORPHISM
    Ryo Nisho, Toshiro Shinke, Junya Shite, Takahiro Sawada, Ryuji Toh, Yoko Haraguchi, Hiromasa Otake, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Yu Taniguchi, Noritoshi Hiranuma, Ken-ichi Hirata
    Apr. 2011, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1210 - E1210, English
    Summary international conference

  • POTENTIAL BENEFIT OF FINAL KISSING INFLATION AFTER SINGLE STENTING TO BIFURCATION LESIONS: DIFFERENCE OF OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN SIROLIMUS AND PACLITAXEL-ELUTING STENTS
    Hirotoshi Hariki, Junya Shite, Toshiro Shinke, Hiromasa Otake, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Tsuyoshi Ohsue, Yu Taniguchi, Nishio Ryo, Noritoshi Hiranuma, Ken-ichi Hirata
    Apr. 2011, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1723 - E1723, English
    Summary international conference

  • NONPOLYMER-BASED BIOLIMUS-ELUTING STENT ACCELERATES OVERALL NEOINTIMAL COVERAGE: SHORT- AND MID-TERM INTRAVASCULAR ULTRASOUND RESULTS FROM STEALTH AND BIOFREEDOM TRIALS
    Kenji Sakata, Byeong-Keuk Kim, Hiromasa Otake, Katsuhisa Waseda, Gerhard C. Schuler, Karl E. Hauptmann, Joachim Schofer, Paul G. Yock, Eberhard Grube, Peter J. Fitzgerald, Yasuhiro Honda
    Apr. 2011, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1756 - E1756, English
    Summary international conference

  • ASSESSMENT OF YELLOW NEOINTIMA AND MURAL THROMBI AFTER 1ST GENERATION SIROLIMUS-ELUTING STENTS USING ANGIOSCOPE AND OPTICAL COHERENCE TOMOGRAPHY
    Takumi Inoue, Toshiro Shinke, Junya Shite, Hiromasa Otake, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Tsuyoshi Ohsue, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Ken-ichi Hirata
    Apr. 2011, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1731 - E1731, English
    Summary international conference

  • OCT (決定版 病棟必携! カラーで診る PCIマニュアル--テクニックとコツの入門書) -- (PCIにおけるイメージング)
    大竹 寛雅, 志手 淳也, 新家 俊郎
    メディカ出版, Mar. 2011, サーキュレーション・アップ・トゥ・デート, 6, 287 - 295, Japanese

  • Comparison of Vessel Response to Sirolimus-Eluting NEVOTM Stents with Bioabsorbable Polymer Versus Sirolimus-Eluting CypherTM Steeds with Durable Polymer
    Hiromasa Otake, Takao Shimohana, Katsuhisa Waseda, Paul G. Yock, Alexandre Abizaid, John Ormiston, Christian Spaulding, Peter J. Fitzgerald, Yasuhiro Honda
    Sep. 2010, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(13) (13), B56 - B56, English
    Summary international conference

  • Comparison of Polymer -Free BioFreedo Struts with Polymer-BasedTABUS"' Liberte Stems: The 4-Nlonth lotravascular Ultrasound Results from the Bioireedoin First -In -Man Trial
    Hiromasa Otake, Byeong-Keuk Kim, Katsuhisa Waseda, Gerhard C. Schuler, Karl E. Hauptmann, Joachim Schafer, Yasuhiro Honda, Eberhard Grube, Peter J. Fitzgerald
    Sep. 2010, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(13) (13), B54 - B54, English
    Summary international conference

  • Comparison of Sirolimus-Eluting NEVO (TM) Stents With Paclitaxel-eluting CoStar (TM) Stents and Paclitaxel-eluting Taxus Liberte (TM) Stents: Insights From Intravascular Ultrasound Analysis of the Res-elution I and Costar II Trials
    Hiromasa Otake, Takao Shimohama, Ichizo Tsujino, Junya Ako, Katsuhisa Waseda, Paul G. Yock, Yasuhiro Honda, Dean J. Kereiakes, Mitch W. Krucoff, Christian Spaulding, John Ormiston, Alexandre Abizaid, Peter J. Fitzgerald
    Nov. 2009, CIRCULATION, 120(18) (18), S915 - S915, English
    Summary international conference

  • Evaluation of the Peri-strut Low Intensity Area Following Sirolimus- and Paclitaxel-Eluting Stents Implantation: Insights From an Optical Coherence Tomography Study in Humans
    Hiromasa Otake, Fumiaki Ikeno, Toshiro Shinke, Tomohiko Teramoto, Takahiro Sawada, Naoki Miyoshi, Junya Ako, Yasuhiro Honda, Paul G. Yock, Peter J. Fitzgerald, Ken-ichi Hirata
    Nov. 2009, CIRCULATION, 120(18) (18), S1000 - S1000, English
    Summary international conference

  • Impact of Lumen Narrowing Within Everolimus-Eluting Stents on Downstream Vessel Segments
    Kenji Sakata, Junya Ako, Katsuhisa Waseda, Masao Yamasaki, Ichizo Tsujino, Takao Shimohama, Hiromasa Otake, Takao Hasegawa, Ryota Sakurai, Paul G. Yock, Krishnankulty Sudhir, Hajime Kusano, Gregg W. Stone, Peter J. Fitzgerald, Yasuhiro Honda
    Sep. 2009, AMERICAN JOURNAL OF CARDIOLOGY, 104(6A) (6A), 18D - 18D, English
    Summary international conference

  • Single Center, First-In-Man Study of the Elixir Novolimus Elating Coronary Stent System with Durable Polymer 24-Month Clinical Safety and Efficacy Results
    Alexandre Abizaid, J. Ribamar Costa, Fausto Feres, Ricardo Costa, Ana Cristina Seixas, Felipe Maia, Rodolfo Staico, Dimytri Siqueira, John Ormiston, Amanda G. M. R. Sousa, Peter Fitzgerald, Yasuhiro Honda, Hiromasa Otake, J. Eduardo Sousa
    Sep. 2009, AMERICAN JOURNAL OF CARDIOLOGY, 104(6A) (6A), 158D - 158D, English
    Summary international conference

  • Comparison of Sirolimus-Eluting NEVOTM Stents with Paclitaxel-eluting Taxus LieberteTM stents in De Novo Native Coronary Artery Lesions : Intravascular Ultrasound Results From the Reselution I Trial
    Hiromasa Otake, Takao Shimohama, Junya Ako, Katsuhisa Waseda, Yasuhiro Honda, Peter J. Fitzgerald
    Sep. 2009, AMERICAN JOURNAL OF CARDIOLOGY, 104(6A) (6A), 133D - 133D, English
    Summary international conference

  • Hiromasa Otake, Junya Shite, Junya Ako
    Aug. 2009, JACC-CARDIOVASCULAR INTERVENTIONS, 2(8) (8), 807 - 808, English
    Report scientific journal

  • Vascular Response to Overlapping Everolimus-eluting stents: Comparison with Paclitaxel-eluting Stents
    Hiromasa Otake, Junys Ako, Masao Yamasaki, Ichizo Tsujino, Takao Shimohama, Takato Hasegawa, Ryota Sakurai, Katsuhisa Waseda, Paul G. Yock, Yasuhiro Honda, Krishnankutty Sudhir, Gregg W. Stone, Peter J. Fitzgerald
    Oct. 2008, AMERICAN JOURNAL OF CARDIOLOGY, 102(8A) (8A), 170I - 170I, English
    Summary international conference

  • Efficacy Of The Everolimus-eluting Stent in Diabetic Patients: Comparison With The Paclitaxel-eluting Stent
    Hiromasa Otake, Junya Ako, Masao Yamasaki, Ichizo Tsujino, Takao Shimohama, Takao Hasegawa, Ryota Sakurai, Katsuhisa Waseda, Paul G. Yock, Yasuhiro Honda, Poornima Sood, Krishnankutty Sudhir, Gregg W. Stone, Peter J. Fitzgerald
    Oct. 2008, CIRCULATION, 118(18) (18), S1042 - S1042, English
    Summary international conference

  • Takao Shimohama, Hiromasa Otake, Junya Ako, Masao Yamasaki, Ichizo Tsujino, Yasuhiro Honda, Shigeru Saito, Gregg W. Stone, Peter J. Fitzgerald
    Oct. 2008, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 45, S29 - S29, English
    Summary international conference

  • Arterial Responses at Proximal and Distal Edges of Everolimus-Eluting Stents: Insights from the Spirit III Randomized Controlled Trial
    Hiromasa Otake, Junya Ako, Masao Yamasaki, Ichizo Tsujino, Takao Shimohama, Takao Hasegawa, Ryota Sakurai, Katsuhisa Waseda, Yasuhiro Honda, Paul G. Yock, Wai-Fung Cheong, Krishnankutty Sudhir, Gregg W. Stone, Peter J. Fitzgerald
    Oct. 2008, CIRCULATION, 118(18) (18), S1045 - S1045, English
    Summary international conference

  • Local Determinants and Clinical Significance of Thrombus Formation Following Sirolimus-Eluting Stent Implantation: Insights from Optical Coherence Tomography Analysis
    Hiromasa Otake, Junya Shite, Junya Ako, Toshiro Shinke, Takahiro Sawada, Koo Bon-Kwon, Paul G. Yock, Yasuhiro Honda, Peter J. Fitzgerald, Ken-ichi Hirata
    Oct. 2008, CIRCULATION, 118(18) (18), S896 - S896, English
    Summary international conference

  • Evaluation of vessel response to percutaneous coronary intervention
    Peter J. Fitzgerald, Hiromasa Otake
    Oct. 2008, REVISTA ESPANOLA DE CARDIOLOGIA, 61(10) (10), 1001 - 1006, Spanish, Castilian
    [Refereed]
    Others

  • A Case of Aortic Regurgitation Associated with Hypereosinophilic Syndrome
    KONISHI Akihide, KAWAI Hiroya, TAWA Hideto, KAWAMORI Hiroyuki, OTAKE Hiromasa, TANAKA Hidekazu, SHINKE Toshiro, YOSHIDA Akihiro, HIRATA Ken-ichi
    日本心臓病学会, 15 May 2008, 日本心臓病学会誌 =Journal of cardiology. Japanese edition, 1(3) (3), 169 - 173, Japanese

  • Evaluation of delayed tissue coverage on sirolimus-eluting stents from six-month to twelve-month - optical coherence tomography study
    D. Matsumoto, J. Shite, T. Shinke, H. Otake, O. Luis Paredes, Y. Tanino, D. Ogasawara, T. Sawada, H. Kato, M. Yokoyama
    Sep. 2007, EUROPEAN HEART JOURNAL, 28, 673 - 673, English
    Summary international conference

  • Coronary plaque regression is closely related to the decrease of necrotic-core with increase of plasma adiponectin level: 6-month binary studies with virtual histology intravascular ultrasound
    D. Ogasawara, J. Shite, T. Shinke, H. Otake, Y. Tanino, T. Sawada, P. Oscar, M. Yokoyama
    Sep. 2007, EUROPEAN HEART JOURNAL, 28, 62 - 62, English
    Summary international conference

  • Effect of pioglitazone on coronary plaque volume and components in patients with type 2 diabetes: intravascular ultrasound virtual histology study
    D. Ogasawara, J. Shite, T. Shinke, H. Otake, Y. Tanino, T. Sawada, P. Oscar, M. Yokoyama
    Sep. 2007, EUROPEAN HEART JOURNAL, 28, 759 - 760, English
    Summary international conference

  • Lower plasma adiponectin levels and higher oxidative stress are associated with in vivo thin-cap fibroatheroma in patients wth sable agina pctoris
    Takahiro Sawada, Junya Shite, Toshiro Shinke, Hiromasa Otake, Yusuke Tanino, Daisuke Ogasawara, Hiroyuki Kawamori, Hiroki Kato, Naoki Miyoshi, Mitsuhiro Yokoyama
    Mar. 2007, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 49(9) (9), 382A - 382A, English
    Summary international conference

  • 1 Catheter-based Transcoronary Myocardial Hypothermia Attenuates Reperfusion Injury in Pigs with Acute Myocardial Infarction(Discovery of Adjunctive Therapies for Acute Myocardial Infarction-From Bench to Bedside-, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
    Shite Junya, Otake Hiromasa, Shinke Toshirou, Hirata Ken-ichi, Yokoyama Mitsuhiro
    Japanese Circulation Society, 01 Mar. 2007, Circulation journal : official journal of the Japanese Circulation Society, 71, 91 - 92, English

  • PE-095 Low Adiponectin Level is Associated with ACS Caused by Plaque Rupture Containing Lipid Necrotic Core(Acute coronary syndrome, basic/clinical-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
    Otake Hiromasa, Shite Junya, Shinke Toshiro, Imuro Yusuke, Paredes Oscar, Ogasawara Daisuke, Sawada Takahiro, Yokoyama Mitsuhiro
    Japanese Circulation Society, 01 Mar. 2007, Circulation journal : official journal of the Japanese Circulation Society, 71, 348 - 349, English

  • A Case of Right Coronary Ostium Stent Dislodgement by a 5Fr JR4 Catheter Resulting in Acute Coronary Occlusion
    OGASAWARA Daisuke, SHITE Junya, SHINKE Toshiro, WATANABE Satoshi, OTAKE Hiromasa, MATUMOTO Daisuke, TANINO Yusuke, SAWADA Takahiro, PAREDES Oscar Luis, YOKOYAMA Mitsuhiro
    10 Oct. 2006, Japanese journal of interventional cardiology, 21(5) (5), 435 - 441, Japanese

  • Pioglitazone increases plasma adiponectin concentration and decreases coronary plaque necrotic core: Intravascular ultrasound virtual histology study
    Daisuke Ogasawara, Junya Shite, Toshiro Shinke, Hiromasa Otake, Yusuke Tanino, Oscar L. Paredes, Takahiro Sawada, Mitsuhiro Yokoyama
    Oct. 2006, CIRCULATION, 114(18) (18), 782 - 783, English
    Summary international conference

  • Cooperative study with intravascular ultrasound virtual histology and optical copherence tomography for detecting thin cap fibroatheroma in patients with stable coronary artery disease
    Toshiro Shinke, Junya Shite, Takahiro Sawada, Hiromasa Otake, Daisuke Matsumoto, Yusuke Tanino, Daisuke Ogasawara, Oscar Luis, Mitsuhiro Yokoyama
    Oct. 2006, AMERICAN JOURNAL OF CARDIOLOGY, 98(8A) (8A), 221M - 221M, English
    Summary international conference

  • Factors for neointimal proliferation in sirolimus-eluting stent at 6 month after deployment, optical coherence tomography study
    Daisuke Matsumoto, Junya Shite, Toshiro Shinke, Hiromasa Otake, Yusuke Tanino, Daisuke Ogasawara, Takahiro Sawada, Oscar Luis Paredes, Mitsuhiro Yokoyama
    Oct. 2006, AMERICAN JOURNAL OF CARDIOLOGY, 98(8A) (8A), 94M - 94M, English
    Summary international conference

  • Evaluation of long-term changes of neointimal coverage on sirolimus-eluting stents by optical coherence tomography
    Matsumoto Daisuke, Shite Junya, Shinke Toshiro, Otake Hiromasa, Ogasawara Daisuke, Tanino Yusuke, Sawada Takahiro, Yokoyama Mitsuhiro
    Oct. 2006, CIRCULATION, 114(18) (18), 645 - 645, English
    Summary international conference

  • Change of neointimal coverage on Sirolimus-eluting stents from six month to twelve month - Optical coherence tomography study
    Daisuke Matsumoto, Junya Shite, Toshiro Shinke, Hiromasa Otake, Yusuke Tanino, Daisuke Ogasawara, Takahiro Sawada, Oscar Luis Paredes, Mitsuhiro Yokoyama
    Oct. 2006, AMERICAN JOURNAL OF CARDIOLOGY, 98(8A) (8A), 94M - 94M, English
    Summary international conference

  • Human atrial natriuretic peptide improves myocardial efficiency in patients with heart failure due to idiopathic dilated cardiomyopathy
    Toshiro Shinke, Junya Shite, Yusuke Tanino, Hiromasa Otake, Oscar Luis, Daisuke Ogasawara, Takahiro Sawada, Mitsuhiro Yokoyama
    Oct. 2006, CIRCULATION, 114(18) (18), 620 - 620, English
    Summary international conference

  • Difference between acute coronary syndrome and stable angina: Relationship between plasma adiponectin, high sensitive C-reactive protein and coronary plaque components
    H. Otake, J. Shite, T. Shinke, D. Ogasawara, T. Sawada, S. Watanabe, D. Matsumoto, M. Yokoyama
    Aug. 2006, EUROPEAN HEART JOURNAL, 27, 231 - 231, English
    Summary international conference

  • Effect of Angiotensin Receptor Blockade on coronary necrotic core plaque: binary observations with intravascular ultrasound virtual histology
    D. Ogasawara, J. Shite, T. Shinke, S. Watanabe, H. Otake, D. Matsumoto, Y. Tanino, M. Yokoyama
    Aug. 2006, EUROPEAN HEART JOURNAL, 27, 365 - 365, English
    Summary international conference

  • 23)Cypher crushed stentを慢性期にoptical coherence tomography (OCT)にて観察した一例(第100回日本循環器学会近畿地方会)
    澤田 隆弘, 志手 淳也, 新家 俊郎, 渡邉 哲史, 大竹 寛雅, 松本 大典, 谷野 祐介, 小笠原 大介, 横山 光宏
    社団法人日本循環器学会, 20 Apr. 2006, Circulation journal : official journal of the Japanese Circulation Society, 70, 1108 - 1108, Japanese

  • 24)ステント内再狭窄病変に対しエキシマレーザー冠動脈形成術を行い,切除結果をOCTで観察した2症例(第100回日本循環器学会近畿地方会)
    小笠原 大介, 志手 淳也, 新家 俊郎, 渡邉 哲史, 伊室 祐介, 大竹 寛雅, 松本 大典, オスカルパレデス, 澤田 隆弘, 横山 光宏
    社団法人日本循環器学会, 20 Apr. 2006, Circulation journal : official journal of the Japanese Circulation Society, 70, 1108 - 1108, Japanese

  • OJ-129 Elevation of Plasma C-Reactive Protein is Associated with Histological Plaque Composition in Patients with Acute Coronary Syndromes(Acute coronary syndrome, basic/clinical-2 (IHD) OJ22,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
    Shinke Toshiro, Shite Junya, Otake Hiromasa, Imuro Yusuke, Watanabe Satoshi, Matsumoto Daisuke, Ogasawara Daisuke, Sawada Takahiro, Paredes Oscar, Yokoyama Mitsuhiro
    Japanese Circulation Society, 01 Mar. 2006, Circulation journal : official journal of the Japanese Circulation Society, 70, 266 - 266, English

  • PJ-090 Evaluation of Sirolimus-eluting Stent Mal-apposition by Optical Coherence Tomography(Intravascular endoscopy/Intravascular ultrasound-6 (I) PJ15,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
    Matsumoto Daisuke, Shite Junya, Shinke Toshiro, Watanabe Satoshi, Otake Hiromasa, Oscar Paredes, Imuro Yusuke, Ogasawara Daisuke, Sawada Takahiro, Yokoyama Mitsuhiro
    Japanese Circulation Society, 01 Mar. 2006, Circulation journal : official journal of the Japanese Circulation Society, 70, 511 - 511, English

  • PE-481 Prognostic Importance of Increased Left Ventricular Myocardial Stiffness in Patients with Recurrent Diastolic Heart Failure(Heart failure, clinical-9 (M) PE81,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
    Watanabe Satoshi, Shite Junya, Takaoka Hideyuki, Shinke Toshiro, Imuro Yusuke, Otake Hiromasa, Matsumoto Daisuke, Ogasawara Daisuke, Sawada Takahiro, Paredes Oscar Luis, Yokoyama Mitsuhiro
    Japanese Circulation Society, 01 Mar. 2006, Circulation journal : official journal of the Japanese Circulation Society, 70, 453 - 453, English

  • OJ-268 Optical Coherence Tomography Visualize Thin Neointima on Sirolimus-eluting Stent More Precisely than Intravascular Ultrasound at Six Month Follow-up(Intravascular endoscopy/Intravascular ultrasound-2 (I) OJ45,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
    Matsumoto Daisuke, Shite Junya, Shinke Toshiro, Watanabe Satoshi, Otake Hiromasa, Oscar Paredes, Imuro Yusuke, Ogasawara Daisuke, Sawada Takahiro, Yokoyama Mitsuhiro
    Japanese Circulation Society, 01 Mar. 2006, Circulation journal : official journal of the Japanese Circulation Society, 70, 301 - 301, English

  • OJ-265 Plasma Adiponectin Levels are Associated with Plaque Component in Patients with Ischemic Heart Disease(Intravascular endoscopy/Intravascular ultrasound-2 (I) OJ45,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
    Otake Hiromasa, Shite Junya, Shinke Toshiro, Imuro Yusuke, Watanabe Satoshi, Matsumoto Daisuke, Ogasawara Daisuke, Sawada Takahiro, Paredes Oscar Louis, Yokoyama Mitsuhiro
    Japanese Circulation Society, 01 Mar. 2006, Circulation journal : official journal of the Japanese Circulation Society, 70, 300 - 300, English

  • Evaluation of neointimal hyperplasia by optical coherence tomography at six month after sirolimus eluting stent deployment
    D Matsumoto, D Matsumoto, J Shite, T Shinke, S Watanabe, T Ozawa, H Otake, OL Paredes, Y Tanino, D Ogasawara, M Yokoyama
    Oct. 2005, AMERICAN JOURNAL OF CARDIOLOGY, 96(7A) (7A), 186H - 186H, English
    Summary international conference

  • Effects of overlapping sirolimus-eluting stent on neointimal proliferation in long coronary lesions: Optical coherence tomography study
    T Shinke, J Shite, D Matsumoto, S Watanabe, H Otake, Y Tanino, D Ogasawara, L Oscar, M Yokayama
    Oct. 2005, AMERICAN JOURNAL OF CARDIOLOGY, 96(7A) (7A), 176H - 176H, English
    Summary international conference

  • Therapeutic doses of human atrial natriuretic peptide have different effects on myocardial contractility in patients with systolic heart failure and left ventricular hypertrophy
    T Shinke, Y Kijima, S Nakatsu, T Ozawa, J Shite, K Hata, H Takaoka, S Watanabe, T Ozawa, H Otake, D Matsumoto, Y Tanino, D Ogasawara, O Luis, M Yokoyama
    Oct. 2005, CIRCULATION, 112(17) (17), U514 - U514, English
    Summary international conference

  • Effectiveness of Catheter-based Trans-coronary Myocardial Hypothermia on Attenuating Myocardial Necrosis in Pigs with Acute Myocardial Infarction(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
    Otake Hiromasa, Shite Junya, Shinke Toshiro, Yoshikawa Ryohei, Imuro Yusuke, Oscar Paredes, Watanabe Satoshi, Ozawa Toru, Matsumoto Daisuke, Ogasawara Daisuke, Yokoyama Mitsuhiro
    Japanese Circulation Society, 01 Mar. 2005, Circulation journal : official journal of the Japanese Circulation Society, 69, 183 - 183, English

  • Multivariate Analysis of Hemodynamic Parameters for Increase in Plasma BNP in Systolic and Diastolic Heart Failure ; Importance of Myocardial Stiffness(Heart Failure, Clinical 13 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
    Watanabe Satoshi, Shite Junya, Takaoka Hideyuki, Shinke Toshiro, Imuro Yusuke, Ozawa Toru, Otake Hiromasa, Matsumoto Daisuke, Ogasawara Daisuke, Yokoyama Mitsuhiro
    Japanese Circulation Society, 01 Mar. 2005, Circulation journal : official journal of the Japanese Circulation Society, 69, 235 - 235, English

  • 26)New distal protection device(PercuSurge^)を用いた急性冠症候群における一検討
    水谷 和郎, 林 孝俊, 宝田 明, 志手 淳也, 池田 嘉宏, 山田 慎一郎, 山城 荒平, 大竹 寛雅, 田辺 慶司, 大島 規広, 高見 薫, 梶谷 定志
    社団法人日本循環器学会, 20 Apr. 2003, Circulation journal : official journal of the Japanese Circulation Society, 67, 817 - 817, Japanese

  • 135)心房細動に対する塩酸ベプリジル投与の検討
    水谷 和郎, 山城 荒平, 宝田 明, 林 孝俊, 志手 淳也, 池田 嘉宏, 山田 慎一郎, 大竹 寛雅, 田辺 慶司, 大島 規広, 高見 薫, 梶谷 定志
    社団法人日本循環器学会, 20 Apr. 2003, Circulation journal : official journal of the Japanese Circulation Society, 67, 828 - 828, Japanese

■ Books And Other Publications
  • PCIマニュアル / PCIにおけるイメージング：OCT
    Otake Hiromasa
    Joint editor, メディカ出版, Mar. 2011, Japanese
    Textbook

  • Oxford text book of interventional cardiology / The role of intravascular ultrasound in percutaneous coronary intervention
    Otake Hiromasa
    Joint work, Oxford University Press, 2010, English
    Textbook

■ Lectures, oral presentations, etc.
  • The morphological characteristics and insufficient lipid control might promote intimal thickening of saphenous vein graft after coronary artery bypass grafting
    Yuichiro Nagano, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Hachidai Takahashi, Takayoshi Toba, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Akira Nagasawa, Hiroyuki Onishi, Yoichiro Sugizaki, Ryo Takeshige, Shinsuke Nakano, Kosuke Tanimura, Yoichiro Matsuoka, Yu Takahashi, Yusuke Fukuyama, Kenichi Hirata
    第83回日本循環器学会学術集会, Mar. 2019, Japanese, 日本循環器学会, 横浜, Domestic conference
    Oral presentation

  • The impact of glucose fluctuation on cardiovascular outcome in patients with stable coronary artery disease
    Hiroyuki Yamamoto, Hiromasa Otake, Toshiro Shinke, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Kenichi Yanaka, Akira Nagasawa, Youichiro Sugizaki, Ryo Takeshige, Hiroyuki Onishi, Kosuke Tanimura, Youichiro Matsuoka, Shinsuke Nakano, Yu Takahashi, Yusuke Fukuyama, Yushi Hirota, Kazuhiko Sakaguchi, Kenichi Hirata
    第83回日本循環器学会学術集会, Mar. 2019, Japanese, 日本循環器学会, 横浜, Domestic conference
    Public symposium

  • The concomitant use of statin and eicosapentaenoic acid prevented atherosclerotic progression in both in-stent neoatherosclerosis and native coronary plaques.
    Yoichiro Sugizaki, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-ichi Yanaka, Hiroyuki Yamamoto, Akira Nagawasa, Hiroyuki Onishi, Ryo Takeshige, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Kenichi Hirata
    第83回日本循環器学会学術集会, Mar. 2019, English, 日本循環器学会, 横浜, Domestic conference
    Oral presentation

  • Post-stent irregular protrusion is associated with future development of neoatherosclerosis: Insights from the MECHANISM-AMI study
    Yoshiro Tsukiyama, Hiromasa Otake, Toshiro Shinke, Tomonori Itoh, Masaru Ishida, Daisuke Terashita, Tetsuya Fusazaki, Tatsuo Kikuchi, Takayuki Okamura, Takashi Morita, Toru Kataoka, Kiyoshi Hibi, Takashi Akasaka, Shozo Ishihara, Yoshihiro Morino, Kenichi Hirata
    第83回日本循環器学会学術集会, Mar. 2019, Japanese, 日本循環器学会, 横浜, Domestic conference
    Oral presentation

  • Plaque progression from normal vessel wall to fibroatheroma: lessons from over 5-year follow-up optical coherence tomography study
    Ryo Takeshige, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-ichi Yanaka, Hiroyuki Yamamoto, Akira Nagawasa, Hiroyuki Onishi, Yoichiro Sugizaki, Yu Takahashi, Yusuke Fukuyama, Kenichi Hirata
    第83回日本循環器学会学術集会, Mar. 2019, English, 日本循環器学会, 横浜, Domestic conference
    Oral presentation

  • Novel Approach for In-vivo Detection of Vulnerable Plaques: Computational Fluid Dynamics in Optical Coherence Tomography and Computed Tomography Merged Model
    Takayoshi Toba, Hiromasa Otake, Gilwoo Choi, Yu Takahashi, Yusuke Fukuyama, Shinsuke Nakano, Kosuke Tanimura, Yoichiro Matsuoka, Ryo Takeshige, Yoichiro Sugizaki, Akira Nagasawa, Hiroyuki Ohnishi, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Yuichiro Nagano, Hiroyuki Kawamori, Charles Taylor, Kenichi Hirata
    第83回日本循環器学会学術集会, Mar. 2019, Japanese, 日本循環器学会, 横浜, Domestic conference
    Public symposium

  • Evaluation of Microvasculopathy using Dual-Energy CT in Chronic Thromboembolic Pulmonary Hypertension
    Hiroyuki Onishi, Yu Taniguchi, Yoichiro Matsuoka, Kenichi Yanaka, Naoki Tamada, Yu Izawa, Yasunori Tuboi, Shumpei Mori, Kazuhiko Nakayama, Hiromasa Otake, Seimi Satomi-Kobayashi, EMOTO NORIAKI, Kenichi Hirata
    第83回日本循環器学会学術集会, Mar. 2019, English, 日本循環器学会, 横浜, Domestic conference
    Poster presentation

  • Different vascular reaction to everolimus-eluting stents implantation between stable angina and ST elevation myocardial infarction: Insights from MECHANISM studies
    Yoshiro Tsukiyama, Hiromasa Otake, Toshiro Shinke, Tomonori Itoh, Masaru Ishida, Daisuke Terashita, Tetsuya Fusazaki, Tatsuo Kikuchi, Takayuki Okamura, Takashi Morita, Toru Kataoka, Kiyoshi Hibi, Takashi Akasaka, Shozo Ishihara, Yoshihiro Morino, Kenichi Hirata
    第83回日本循環器学会学術集会, Mar. 2019, Japanese, 日本循環器学会, 横浜, Domestic conference
    Oral presentation

  • Comparison of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, and Cholesterol Efflux Capacity in Association with Coronary Plaque Properties
    Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Koichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Satomi-Kobayashi Seimi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake, Tatsuro Ishida, Kenichi Hirata
    第83回 日本循環器学会学術集会, Mar. 2019, English, 日本循環器学会, 横浜, Background: Cholesterol efflux capacity (CEC) measurement is not instantly applicable in clinical settings, because the procedures require cultured cells and are time consuming. Recently, we established a simple, high-throughout, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as “cholesterol uptake capacity (, Domestic conference
    Poster presentation

  • Clinical characteristics and morphological culprit plaque features in patients with acute coronary syndrome
    Akira Nagasawa, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-ichi Yanaka, Hiroyuki Yamamoto, Hiroyuki Onishi, Youichiro Sugizaki, Ryo Takeshige, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Kenichi Hirata
    第83回日本循環器学会学術集会, Mar. 2019, English, 日本循環器学会, 横浜, Domestic conference
    Oral presentation

  • A possible link between asymmetric expansion of SAPIEN 3 transcatheter heart valve and hypo-attenuated leaflet thickening
    Hiroyuki Kawamori, Hiromasa Otake, Takayoshi Toba, Yuichiro Nagano, Hiroyuki Yamamoto, Yoshiro Tsukiyama, Kenichi Yanaka, Yoichiro Sugizaki, Hiroyuki Onishi, Ryo Takeshige, Shinsuke Nakano, Kosuke Tanimura, Yoichiro Matsuoka, Yu Takahashi, Yusuke Fukuyama, Noriyuki Negi, Kenichi Hirata
    第83回日本循環器学会学術集会, Mar. 2019, English, 日本循環器学会, 横浜, Domestic conference
    Poster presentation

  • Comparison of Clinical Utility Between Cholesterol Uptake Capacity, a Novel Indicator of HDL Functionality, and Cholesterol Efflux Capacity
    Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Koichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Satomi-Kobayashi Seimi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake, Tatsuro Ishida, Ken-ichi Hirata
    第35回 国際心臓研究学会日本部会, Dec. 2018, English, 国際心臓研究学会日本部会, 東京, Background: Cholesterol efflux capacity (CEC) measurement is not instantly applicable in clinical settings, because the methods require cultured cells, and the procedures are time consuming. Recently, we established a simple, high-throughout, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as “cholesterol upta, Domestic conference
    Poster presentation

  • Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, Versus Cholesterol Efflux Capacity in Association with Coronary Plaque Lipid Burden
    Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Koichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Satomi-Kobayashi Seimi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake, Tatsuro Ishida, Kenichi Hirata
    American Heart Association Scientific Sessions 2018., Nov. 2018, English, American Heart Association, シカゴ, Background: Cholesterol efflux capacity (CEC) measurement is not instantly applicable in clinical settings, because the methods require cultured cells, and the procedures are time consuming. Recently, we established a simple, high-throughout, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as “cholesterol upta, International conference
    Poster presentation

  • 経カテーテル的心房中隔閉鎖術が奏功した超高齢者重症心不全の一例
    鈴木麻希子, MATSUMOTO KENSUKE, 須藤麻貴子, 谷村幸亮, 中野慎介, 谷口弥生, TANAKA HIDEKAZU, OTAKE HIROMASA, 新家俊郎, HIRATA KENICHI
    日本超音波医学会 第45 回関西地方会学術集会, Oct. 2018, Japanese, 神戸, Domestic conference
    Oral presentation

  • The Impact of P2Y12 Reaction Unit on Intra-stent Tissues and Peri-procedural Myocardial Injury in Stable Angina Pectoris
    Yoshiro Tsukiyama, Toshiro Shinke, Tomonori Ito, Masaru Ishida, Hiromasa Otake, Tetsuya Fusazaki, Tatsuo Kikuchi, Takayuki Okamura, Takashi Morita, Toru Kataoka, Kiyoshi Hibi, Takashi Akasaka, Shozo Ishihara, Yoshihiro Morino, Kenichi Hirata
    第66回 日本心臓病学会, Sep. 2018, English, 日本心臓病学会, 大阪, Domestic conference
    Poster presentation

  • The concomitant use of statin and eicosapentaenoic acid prevented atherosclerotic progression in both in-stent neoatherosclerosis and native coronary plaques.
    Yoichiro Sugizaki, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-ichi Yanaka, Hiroyuki Yamamoto, Akira Nagawasa, Hiroyuki Onishi, Ryo Takeshige, Kenichi Hirata
    Transcatheter Cardiovascular Therapeutics (TCT 2018), Sep. 2018, English, 心血管研究財団, サンディエゴ, International conference
    Poster presentation

  • Prediction of debulking effect of rotational atherectomy by optical frequency domain imaging
    Kosuke Tanimura, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-ichi Yanaka, Hiroyuki Yamamoto, Akira Nagawasa, Hiroyuki Onishi, Ryo Takeshige, Yoichiro Sugizaki, Kenichi Hirata
    Transcatheter Cardiovascular Therapeutics (TCT2018), Sep. 2018, English, 心血管研究財団, サンディエゴ, International conference
    Poster presentation

  • Impact of dual antiplatelet therapy with low-dose prasugrel on mid-term vascular response after everolimus-eluting stent implantation in elective percutaneous coronary intervention
    Takayoshi Toba, Toshiro Shinke, Hiromasa Otake, Yoichiro Sugizaki, Ryo Takeshige, Hiroyuki Onishi, Akira Nagasawa, Yoshiro Tsukiyama, Ken-ichi Yanaka, Yuichiro Nagano, Hiroyuki Yamamoto, Hiroyuki Kawamori, Akira Matsuura, Takayuki Ishihara, Daisuke Matsumoto, Nobuaki Igarashi, Takatoshi Hayashi, Yoshinori Yasaka, Makoto Kadotani, Takashi Fujii, Junya Shite, Masaharu Okada, Takashi Sakakibara, Kenichi Hirata
    Transcatheter Cardiovascular Therapeutics (TCT 2018), Sep. 2018, English, 心血管研究財団, サンディエゴ, International conference
    Poster presentation

  • 慢性血栓塞栓性肺高血圧に対する肺動脈内膜血栓摘除術及びバルーン肺動脈形成術の特性を活かしたハイブリッド療法
    谷仲 謙一, NAKAYAMA KAZUHIKO, TANIGUCHI YUU, OTAKE HIROMASA, KAWAMORI HIROYUKI, 新倉 悠人, 玉田 直己, 大西 裕之, 松岡 庸一郎, TANAKA HIROSHI, 大北 裕, SHINKE TOSHIRO, EMOTO NORIAKI, HIRATA KENICHI
    第27回日本心血管インターベンション治療学会, Aug. 2018, Japanese, 日本心血管インターベンション治療学会, 神戸, Domestic conference
    Public symposium

  • 慢性血栓塞栓性肺高血圧に対する肺動脈内膜血栓摘除術及びバルーン肺動脈形成術の特性を活かしたハイブリッド療法
    谷仲謙一, NAKAYAMA KAZUHIKO, TANIGUCHI YUU, OTAKE HIROMASA, KAWAMORI HIROYUKI, 新倉悠人, 玉田直己, 大西裕之, 松岡庸一郎, TANAKA HIROSHI, OKITA YUTAKA, SHINKE TOSHIRO, EMOTO NORIAKI, HIRATA KENICHI
    第27回日本心血管インターベンション治療学会学術集会, Aug. 2018, Japanese, 日本心血管インターベンション治療学会, 神戸, Domestic conference
    Public symposium

  • TAVR後、人口弁への血栓形成を認めた血小板低下患者の一例
    中野 槙介, KAWAMORI HIROYUKI, OTAKE HIROMASA, 黒田 浩史, 新倉 悠人, 田原 奈津子, 鳥羽 敬義, 永野 雄一朗, 築山 義朗, 山本 裕之, 谷仲 謙一, 長澤 智, 大西 裕之, 竹重 遼, 杉﨑 陽一郎, 谷村 幸亮, 河野 慎吾, 松岡 庸一郎, SHINKE TOSHIRO, HIRATA KENICHI
    第27回日本心血管インターベンション治療学会, Aug. 2018, Japanese, 日本心血管インターベンション治療学会, 神戸, Domestic conference
    Oral presentation

  • Lung perfusion recovery evaluated by dual-energy CT correlated with the improvement of exercise capacity in chronic thromboembolic pulmonary hypertension
    Hiroyuki Onishi, Kazuhiko Nakayama, Ken-ichi Yanaka, Naoki Tamada, Yu Izawa, Yuto Shinkura, Yasunori Tuboi, Shinsuke Shimoyama, Tatsuya Nishii, Atushi Kono, Noriyuki Negi, Shumpei Mori, Hiromasa Otake, Satomi-Kobayashi Seimi, Toshiro Shinke, Noriaki Emoto, Kenichi Hirata
    EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2018(ESC 2018), Aug. 2018, English, European Society of Cardiology, ミュンヘン, International conference
    Poster presentation

  • Lung perfusion recovery evaluated by dual-energy CT correlated with the improvement of exercise capacity in chronic thromboembolic pulmonary hypertension
    Hiroyuki Onishi, Kazuhiko Nakayama, Kenichi Yanaka, Noaki Tamada, Yu Izawa, Yuto Shinkura, Syunsuke Shimoyama, Tatsuya Nishii, Atsushi Kono, Shumpei Mori, Hiromasa Otake, Seimi Satomi-Kobayashi, Toshiro Shinke, Noriaki Emoto, Kenichi Hirata
    ESC Congress 2018, Aug. 2018, English, European Sciety of Cardiology, ミュンヘン, International conference
    Poster presentation

  • Impact of irregular protrusion immediately after stent implantation on mid-term vascular healing in ST elevation myocardial infarction: Results from MECHANISM AMI optical coherence tomography study
    Yoshiro Tsukiyama, Toshiro Shinke, Tomonori Ito, Masaru Ishida, Hiromasa Otake, Tetsuya Fusazaki, Tatsuo Kikuchi, Takayuki Okamura, Takashi Morita, Toru Kataoka, Kiyoshi Hibi, Takashi Akasaka, Shozo Ishihara, Yoshihiro Morino, Kenichi Hirata
    EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2018(ESC 2018), Aug. 2018, English, European Society of Cardiology, ミュンヘン, International conference
    Poster presentation

  • FFRCTの可能性
    OTAKE HIROMASA
    第27回日本心血管インターベンション治療学会, Aug. 2018, Japanese, 日本心血管インターベンション治療学会, 神戸, Domestic conference
    Public discourse

  • Elevation of Serum Trans-fatty Acids Level as a Possible Risk for Target Lesion Revascularization After Coronary Intervention
    Toshihiko Oshita, Ryuji Toh, Kenta Mori, Yasuhiro Irino, Masakazu Shinohara, Hiromasa Otake, Tatsuro Ishida, Kenichi Hirata
    第66回 日本心臓病学会学術集会, Aug. 2018, English, 日本心臓病学会, 大阪, L) (92.7% vs. 70.0%, p=0.004). In addition, the cox proportional hazard models revealed that elevated serum EA level to be an independent element in predicting of TLR after adjusting for traditional coronary risks (HR, 1.06; 95% CI, 1.00-1.12; p=0.04).Conclusions: The present findings indicated that the elevation of serum TFAs could be a cardiovascular risk in Japan., Domestic conference
    Oral presentation

  • Difference of vascular reaction to 2nd generation DES between stable angina and ST elevation myocardial infarction : Results from MECHANISM optical coherence tomography study
    Yoshiro Tsukiyama, Toshiro Shinke, Tomonori Ito, Masaru Ishida, Hiromasa Otake, Tetsuya Fusazaki, Tatsuo Kikuchi, Takayuki Okamura, Takashi Morita, Toru Kataoka, Kiyoshi Hibi, Takashi Akasaka, Shozo Ishihara, Yoshihiro Morino, Kenichi Hirata
    EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2018(ESC 2018), Aug. 2018, English, European Society of Cardiology, ミュンヘン, International conference
    Poster presentation

  • Comparison between pulmonary endarterectomy and balloon pulmonary angioplasty focusing on RC time constant and pulmonary artery compliance in chronic thromboembolic pulmonary hypertension.
    Kenichi Yanaka, Kazuhiko Nakayama, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuto Shinkura, Naoki Tamada, Hiroyuki Onishi, Yoichiro Matsuoka, Hiroshi Tanaka, Yutaka Okita, Noriaki Emoto, Kenichi Hirata
    EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2018(ESC 2018), Aug. 2018, English, European Society of Cardiology, ミュンヘン, International conference
    Poster presentation

  • Comparison between pulmonary endarterectomy and balloon pulmonary angioplasty focusing on RC time constant and pulmonary artery compliance in chronic thromboembolic pulmonary hypertension.
    Kenichi Yanaka, Kazuhiko Nakayama, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuto Shinkura, Naoki Tamada, Hiroyuki Onishi, Yoichiro Matsuoka, Hiroshi Tanaka, Yutaka Okita, Noriaki Emoto, Kenichi Hirata
    ESC Congress 2018, Aug. 2018, English, European Society of Cardiology, ミュンヘン, International conference
    Poster presentation

  • CTEPHに対する治療効果及びRC timeの臨床的意義について
    谷仲 謙一, NAKAYAMA KAZUHIKO, TANIGUCHI YUU, 新倉 悠人, 玉田 直己, 大西 裕之, 松岡 庸一郎, KAWAMORI HIROYUKI, OTAKE HIROMASA, SHINKE TOSHIRO, EMOTO NORIAKI, HIRATA KENICHI
    第3回 日本肺高血圧・肺循環学会学術集会, Jun. 2018, Japanese, 日本肺高血圧・肺循環学会, 大阪, Domestic conference
    Oral presentation

  • CTEPH に対する治療効果の比較及びRC time の臨床的意義について
    谷仲 謙一, NAKAYAMA KAZUHIKO, TANIGUCHI YUU, 新倉 悠人, 玉田 直己, 大西 裕之, 松岡 庸一郎, KAWAMORI HIROYUKI, OTAKE HIROMASA, SHINKE TOSHIRO, EMOTO NORIAKI, HIRATA KENICHI
    第3回日本肺高血圧・肺循環学会学術集会, Jun. 2018, Japanese, 日本肺高血圧学会日本肺循環学会共催, 大阪, Domestic conference
    Oral presentation

  • Exploring MECHANISM of early and late vascular responses of sirolimus-eluting stent with bioresorbable polymer for treatment of STEMI and SAP patients -Primary endpoint results of MECHANISM-ULTIMASTER trial
    OTAKE HIROMASA
    EuroPCR 2018, May 2018, English, European Association of Percutaneous Cardiovascular Interventions (EAPCI), パリ, International conference
    Oral presentation

  • HDL機能の新規評価法“Cholesteroluptakecapacity”とOCT解析によ る冠動脈プラーク病変性状の比較検討
    尾下寿彦, TOH RYUJI, IRINO YASUHIRO, 黒田浩史, 永野雄一郎, 長澤圭典, OTAKE HIROMASA, SHINKE TOSHIRO, ISHIDA TATSURO, HIRATA KENICHI
    第55回 日本臨床分子医学会学術集会, Apr. 2018, Japanese, 日本臨床分子医学会, 京都, 【背景】 高比重リポ蛋白（HDL）の、コレステロールをマクロファージより引き抜く能力cholesterol efflux capacityがHDL中のコレステロール（HDL-C）値より心血管疾患のリスク評価に優れるが、その従来の測定法は放射性同位体や培養細胞を要すなど臨床応用は非現実的であった。当施設で、HDLのコレステロール取り込み能をより簡便に評価できる新規HDL機能評価法“cholesterol uptake capacity (CUC)”を構築し、臨床応用を目指している。この引き抜き能と動脈硬化病変のプラーク性状の関係性に関しこれまでに十分評価はされていない。【方法】 冠動脈病変に対し冠動脈造影検査および光干渉断層映像法（OCT）を施行した135例でCUCを測定しOCT画像解析によるプラーク性状との比較検討を行った。OCT画像上、脂質プラーク, Domestic conference
    Poster presentation

  • Treatment goal of BPA would be extensive perfusion recovery beyond hemodynamic normalization
    Hiroyuki Onishi, Nakayama Kazuhiko, Kenichi Yanaka, Naoki Tamada, Yu Izawa, Yuto Shinkura, Yasunori Tuboi, Shinsuke Shimoyama, Tatsuya Nishii, Atushi Kono, Noriyuki Negi, Shumpei Mori, Otake Hiromasa, Kobayashi Seimi, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi
    第82回 日本循環器学会学術集会, Mar. 2018, English, 日本循環器学会, 大阪, Domestic conference
    Poster presentation

  • Sequential Hybrid Therapy with Pulmonary Endarterectomy and Additional Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension（ポスター発表）
    Kenichi Yanaka, Nakayama Kazuhiko, Shinke Toshiro, Otake Hiromasa, Hiroyuki Kawamori, Takayoshi Toba, Yuto Shinkura, Koji Kuroda, Natsuko Tahara, Yuichiro Nagano, Naoki Tamada
    第82回 日本循環器学会学術集会, Mar. 2018, English, 日本循環器学会, 大阪, Domestic conference
    Poster presentation

  • Relationships between Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, and Morphologic Features of Coronary Plaque
    Toshihiko Oshita, Toh Ryuji, Yuichiro Nagano, Koji Kuroda, Yoshinori Nagasawa, Amane Harada, Katsuhiro Murakami, Irino Yasuhiro, Hara Tetsuya, Shinohara Masakazu, Otake Hiromasa, Shinke Toshiro, Ishida Tatsuro, Hirata Ken-ichi
    The 82th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2018, English, Japanese Circulation Society, 大阪, Background: Recently, we established a simple, high-throughput, cell-free assay system to evaluate the capacity of high-density lipoprotein (HDL) to accept additional cholesterol, named cholesterol uptake capacity (CUC). In this study, we sought to clarif, Domestic conference
    Poster presentation

  • Relationship among Aortic Elongation, Tortuosity, and Configurations of the Aortic Root in Candidates for Transcatheter Aortic Valve Replacement
    Takayoshi Toba, Shumpei Mori, Yu Izawa, Shinsuke Shimoyama, Hiroyuki Toh, Daisuke Tsuda, Natsuko Tahara, Hiroyuki Kawamori, Otake Hiromasa, Tanaka Hidekazu, Sei Fujiwara, Shinke Toshiro, Hirata Ken-ichi
    JCS2018, Mar. 2018, English, 日本循環器学会, 大阪, Domestic conference
    Poster presentation

  • Impaired HDL cholesterol uptake capacity which measure HDL functionality might promote neoatherosclerosis formation after stent implantation
    Yuichiro Nagano, Otake Hiromasa, Amane Harad, Katsuhiro Murakami, Toshihiko Oshita, Irino Yasuhiro, Takayoshi Toba, Koji Kuroda, Natsuko Tahara, Yuto Shinkura, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Akira Nagasawa, Hiroyuki Onishi, Youichirou Sugizaki, RyoTakeshige, Hiroyuki Kawamori, Shinke Toshiro, Ishida Tatsuro, Toh Ryuji, Hirata Ken-ichi
    American College Of Cardiology 67th Annual Scientific Session(ACC2018), Mar. 2018, English, American College Of Cardiology, オーランド, 米国, International conference
    Poster presentation

  • Impact of Aortic Valve Calcification Burden and Distribution on Postprocedural Cardiac Conduction Disturbances following Transcatheter Aortic Valve Replacement
    Natsuko Tahara, Shumpei Mori, Shinsuke Shimoyama, Takayoshi Toba, Yu Izawa, Hiroyuki Toh, Daisuke Tsuda, Hiroyuki Kawamori, Otake Hiromasa, Tanaka Hidekazu, Sei Fujiwara, Shinke Toshiro, Hirata Ken-ichi
    JCS2018, Mar. 2018, English, 日本循環器学会, 大阪, Domestic conference
    Poster presentation

  • Sequential hybrid therapy with pulmonary endarterectomy and additional balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension.
    Kenichi Yanaka, Nakayama Kazuhiko, Shinke Toshiro, Otake Hiromasa, Hiroyuki Kawamori, Yuto Shinkura, Naoki Tamada, Hiroyuki Onishi, Yasunori Tsuboi, Kobayashi Seimi
    6th World Symposium on Pulmonary Hypertension, Feb. 2018, English, 6th World Symposium on Pulmonary Hypertension working group, ニース, フランス, International conference
    Poster presentation

  • Pulmonary Blood Volume by Dual-energy CT is a new management index for chronic thromboembolic pulmonary hypertension
    Hiroyuki Onishi, Nakayama Kazuhiko, Kenichi Yanaka, Naoki Tamada, Yu Izawa, Yuto Shinkura, Yasunori Tuboi, Shinsuke Shimoyama, Tatsuya Nishii, Atushi Kono, Noriyuki Negi, Shumpei Mori, Otake Hiromasa, Kobayashi Seimi, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi
    6th World Symposium on Pulmonary Hypertension, Feb. 2018, English, 6th World Symposium on Pulmonary Hypertension working group, ニース, フランス, International conference
    Poster presentation

  • Predictors for worsening hemodynamics during follow-up period after balloon pulmonary angioplasty
    Yuto Shinkura, Nakayama Kazuhiko, Hiroyuki Ohnishi, Kenichi Yanaka, Naoki Tamada, Yasunori Tsuboi, Kobayashi Seimi, Otake Hiromasa, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi
    6th World Symposium on Pulmonary Hypertension, Feb. 2018, English, 6th World Symposium on Pulmonary Hypertension working group, ニース, フランス, International conference
    Poster presentation

  • 慢性血栓塞栓性肺高血圧症に対するバルーン拡張術におけるpressure wireを用いた病変別急性効果の検討
    谷仲謙一, Nakayama Kazuhiko, Shinke Toshiro, Otake Hiromasa, 鳥羽敬義, 新倉悠人, 黒田浩史, 田原奈津子, 永野雄一朗, 築山義朗, 山本裕之, 玉田直己, 長澤智, 大西裕之, 竹重遼, 杉﨑陽一郎, 江本憲昭, Hirata Ken-ichi
    第124回日本循環器学会近畿地方会, Nov. 2017, Japanese, 日本循環器学会, 大阪, Domestic conference
    Oral presentation

  • Pulmonary blood volume evaluated by dual-energy CT is a new maker for the management of chronic thromboembolic pulmonary hypertension
    Hiroyuki Onishi, Nakayama Kazuhiko, Ken-ichi Yanaka, Naoki Tamada, Yuto Shinkura, Yasunori Tuboi, Shinsuke Shimoyama, Tatsuya Nishii, Atushi Kono, Noriyuki Negi, Shumpei Mori, Otake Hiromasa, Kobayashi Seimi, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi
    American Heart Association Scientific Sessions 2017, Nov. 2017, English, American Heart Association, アナハイム, USA, International conference
    Poster presentation

  • Association of Coronary Lipidic Plaque Burden with Impairment of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality: OCT-based Observation Study
    Toshihiko Oshita, Toh Ryuji, Yuichiro Nagano, Koji Kuroda, Yoshinori Nagasawa, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Irino Yasuhiro, Otake Hiromasa, Shinke Toshiro, Ishida Tatsuro, Hirata Ken-ichi
    American Heart Association Scientific sessions 2017, Nov. 2017, English, American Heart Association, Anaheim, USA, Background: Recent studies have shown that the capacity of high density lipoprotein (HDL) to stimulate cholesterol efflux from lipid-laden macrophages is a better predictor of cardiovascular disease than overall HDL cholesterol level. However, the convent, International conference
    Oral presentation

  • The combination of rosuvastatin (10mg) and eicosapentaenoic acid (1800mg) improved native coronary plaques > 5.7 years after stent implantation
    Youichirou Sugizaki, Otake Hiromasa, Shinke Toshiro, Hiroyuki Kawamori, Koji Kuroda, Takayoshi Toba, Natsuko Tahara, Yuto Shinkura, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-ichi Yanaka, Hiroyuki Yamamoto, Akira Nagawasa, Hiroyuki Onishi, Ryo Takeshige, Hirata Ken-ichi
    Transcatheter Cardiovascular Therapeutics (TCT 2017), Oct. 2017, English, Cardiovascular Research Foundation（CRF）, デンバー, 米国, International conference
    Oral presentation

  • The clinical impact of daily glucose fluctuation on cardiovascular events in patients with stable angina pectoris pretreated with lipid-lowering therapy
    Hiroyuki Yamamoto, Shinke Toshiro, Otake Hiromasa, Masaru Kuroda, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Koji Kuroda, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Yoshinori Nagasawa, Yuichiro Nagano, Yoshiro Tsukiyam, Ken-ichi Yanaka, Hirota Yushi, Sakaguchi Kazuhiko, Hirata Ken-ichi
    Transcatheter Cardiovascular Therapeutics (TCT 2017), Oct. 2017, English, Cardiovascular Research Foundation（CRF）, デンバー, 米国, International conference
    Poster presentation

  • High Wall Shear Stress Was Strongly Associated with Plaque Vulnerability in Computational Fluid Dynamics with Combined Optical Coherence Tomography and Heartflow FFRCT Simulation
    Takayoshi Toba, Gilwoo Choi, Yuichiro Nagano, Ryo Takeshige, Shumpei Mori, Shinke Toshiro, Charles Taylor, Otake Hiromasa
    Transcatheter Cardiovascular Therapeutics (TCT 2017), Oct. 2017, English, Cardiovascular Research Foundation（CRF）, デンバー, 米国, International conference
    Poster presentation

  • Different tissue morphology of in-stent restenosis in hemodialysis patients compared with non-hemodialysis patients: a prospective multicenter optical coherence tomography registry
    Yoshinori Nagasawa, Shinke Toshiro, Masaru Kuroda, Daiji Kashiwagi, Otake Hiromasa, Tomofumi Takaya, Daisuke Matsumoto
    Transcatheter Cardiovascular Therapeutics (TCT 2017), Oct. 2017, English, Cardiovascular Research Foundation（CRF）, デンバー, 米国, International conference
    Oral presentation

  • The Impact of P2Y12 Reaction Unit during Percutaneous Coronary Intervention on Intra-stent Tissues and Peri-procedural Myocardial Injury in Stable Angina Pectoris; from MECHANISM-elective study
    Yoshiro Tsukiyama, Shinke Toshiro, Tomonori Itoh, Masaru Ishida, Otake Hiromasa, Tetsuya Fusazaki, Tatsuo Kikuchi, Takayuki Okamura, Takashi Morita, Toru Kataoka, Kiyoshi Hibi, Takashi Akasaka, Shozo Ishihara, oshihiro Morino, Hirata Ken-ichi
    EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2017(ESC 2017), Aug. 2017, English, European Society of Cardiology, バルセロナ, スペイン, International conference
    Poster presentation

  • Lesional and clinical impact of drug-coating balloon on in-stent restenosis compared with conventional balloon angioplasty: a prospective multicentre optical coherence tomography registry
    Masaru Kuroda, Shinke Toshiro, Otake Hiromasa, H. Okamoto, N. Hiranuma, N. Igarashi, D. Kamoi, M. Kawata, M. Kadotani, K. Yoshikawa, D. Matsumoto, Y. Yasaka, J. Shite, Hirata Ken-ichi
    EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2017(ESC 2017), Aug. 2017, English, European Society of Cardiology, バルセロナ, スペイン, International conference
    Oral presentation

  • IVUSを用いたbail out
    Otake Hiromasa
    Cardiovascular Interventionand Therapeuticsacientific meeting 2017(CVIT2017), Jul. 2017, Japanese, Japanese Association of Cardiovascular Intervention and Therapeutics, 京都, Domestic conference
    [Invited]
    Invited oral presentation

  • IVUS-guided vs. OFDI-guided PCI: Clinical trial evidence
    Otake Hiromasa
    Cardiovascular Interventionand Therapeuticsacientific meeting 2017(CVIT2017), Jul. 2017, English, Japanese Association of Cardiovascular Intervention and Therapeutics, 京都, Domestic conference
    [Invited]
    Invited oral presentation

  • Follow-up OCT in BRS
    Otake Hiromasa
    Cardiovascular Interventionand Therapeuticsacientific meeting 2017(CVIT2017), Jul. 2017, Japanese, Japanese Association of Cardiovascular Intervention and Therapeutics, 京都, Domestic conference
    [Invited]
    Invited oral presentation

  • Coronary physiology in Japan
    Otake Hiromasa
    Cardiovascular Interventionand Therapeuticsacientific meeting 2017(CVIT2017), Jul. 2017, English, Japanese Association of Cardiovascular Intervention and Therapeutics, 京都, Domestic conference
    [Invited]
    Invited oral presentation

  • Characteristics of pressure gradient in each lesions before and after balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension
    Kenichi Yanaka, Nakayama Kazuhiko, Shinke Toshiro, Otake Hiromasa, Yuto Shinkura, Naoki Tamada, Hiroyuki Onishi, Noriaki Emoto, Hirata Ken-ichi
    International CTEPH conference 2017, Jun. 2017, English, International CTEPH association, Leuven, ベルギー, International conference
    Poster presentation

  • Lumen boundaries extracted from coronary CT angiography on computed FFR (FFRCT): validation with OCT
    Otake Hiromasa, Kenzo Uzu, Choi Gil woo, Takayoshi Toba, Grady Lee, Shinke Toshiro, Charles Taylor
    Japanese Pulmonary Hypertension Society(JPHS)・Japanese Pulmonary Circulation Society(JPCS), May 2017, English, European Association of Percutaneous Cardiovascular Interventions (EAPCI), パリ, フランス, International conference
    Oral presentation

  • Serum Phosphate Level Predicts Total Aortic Calcification Burden in Patients with Severe Aortic Stenosis
    Daisuke Terashita, Shumpei Mori, Natsuko Tahara, Yu Izawa, Takayoshi Toba, Sei Fujiwara, Hiroki Matsuzoe, Matsumoto Kensuke, Tanaka Hidekazu, Otake Hiromasa, Shinke Toshiro, Nishii Tatsuya, Kono Atsushi, Hirata Ken-ichi
    第84回日本循環器学会学術大会, Mar. 2017, English, 日本循環器学会, 金沢, Domestic conference
    Keynote oral presentation

  • Safety of Complete Revascularization of Balloon Pulmonary Angioplasty on Chronic Thromboembolic Pulmonary Hypertension beyond Normalized Mean Pulmonary Arterial Pressure
    Yuto Shinkura, Nakayama Kazuhiko, Kenichi Yanaka, Yoshiro Tsukiyama, Hiroyuki Yamamoto, Yuichiro Nagano, Naoki Tamada, Yoshinori Nagasawa, Natsuko Tahara, Kenzo Uzu, Koji Kuroda, Yasunori Tsuboi, Daisuke Terashita, Hachidai Takahashi, Takayoshi Toba, Tanaka Hidekazu, Otake Hiromasa, Kobayashi Seimi, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi
    第81回 日本循環器学会学術集会, Mar. 2017, English, 日本循環器学会, 金沢, Domestic conference
    Poster presentation

  • Inverse Association Between HDL Cholesterol Uptake Capacity And Coronary Atherosclerotic Burden: OCT-based Observation Study
    Toshihiko Oshita, Toh Ryuji, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Kenta Mori, Irino Yasuhiro, Otake Hiromasa, Shinke Toshiro, Ishida Tatsuro, Hirata Ken-ichi
    The 82st Annual Scientific Meetign of the Japanese Circulation Society, Mar. 2017, English, Japanese Circulation Society, 金沢, Background: High-Density lipoprotein (HDL) function is a better predictor of cardiovascular disease than HDL cholesterol level. Recently, we established a simple, high-throughout, cell-free assay system to evaluate "cholesterol uptake capacity (CUC)" as a, Domestic conference
    Oral presentation

  • Comparison of Left Ventricular Outflow Tract Area Estimated by Transthoracic Echocardiography and Measured by Computed Tomography
    Yu Izawa, Shumpei Mori, Natsuko Tahara, Daisuke Terashita, Takayoshi Toba, Sei Fujiwara, Hiroki Matsuzoe, Matsumoto Kensuke, Tanaka Hidekazu, Otake Hiromasa, Shinke Toshiro, Nishii Tatsuya, Kono Atsushi, Hirata Ken-ichi
    第81回日本循環器学会学術大会, Mar. 2017, English, 日本循環器学会, 金沢, Domestic conference
    Poster presentation

  • Clinical and Practical Assessment of Dysfunctional HDL in Cardiovascular Risk Stratification
    Ishida Tatsuro, Toh Ryuji, Otake Hiromasa, Shinke Toshiro, Amane Harada, Hirata Ken-ichi
    The 85st Annual Scientific Meetign of the Japanese Circulation Society, Mar. 2017, English, Japanese Circulation Society, 金沢, While there is a controversy regarding the clinical significance of high-density lipoprotein cholesterol (HDL-C), recent studies have highlighted the quality of HDL particle as a novel target for cardiovascular risk stratification. However, it is difficul, Domestic conference
    Keynote oral presentation

  • Aortic Valve Calcification Density Predicts the Hemodynamic Severity of Aortic Stenosis Independently of Aortic Valve Area
    Takayoshi Toba, Shumpei Mori, Natsuko Tahara, Yu Izawa, Daisuke Terashita, Hiroki Matsuzoe, Matsumoto Kensuke, Tanaka Hidekazu, Otake Hiromasa, Sei Fujiwara, Shinke Toshiro, Nishii Tatsuya, Kono Atsushi, Hirata Ken-ichi
    第85回日本循環器学会学術大会, Mar. 2017, English, 日本循環器学会, 金沢, Domestic conference
    Poster presentation

  • Why does thin-cap fibroatheroma cluster in the proximal segment in left anterior coronary artery, but are evenly distributed throughout the entire right coronary artery? –Results from computational fluid dynamics simulation by CT-FFR-
    鳥羽 敬義, Gilwoo Choi, Hyun Jin Kim, Arjun Roy, Tran Nguyen, Michiel Schaa, Leo Grady, 宇津 賢三, Mori Shunpei, Shinke Toshiro, Bon-Kwon Koo, Charles Taylor, Otake Hiromasa
    Transcatheter Cardiovascular Therapeutics (TCT 2016), Oct. 2016, English, Cardiovascular Research Foundation（CRF）, ワシントンDC, 米国, International conference
    Poster presentation

  • OPINION:OCT Follow-Up Substudy from a RandomizedTrial of OFDI-Guided PCI vs. IVUS-Guided PCI
    Otake Hiromasa
    Transcatheter Cardiovascular Therapeutics (TCT 2016), Oct. 2016, English, Cardiovascular Research Foundation（CRF）, ワシントンDC, 米国, International conference
    [Invited]
    Invited oral presentation

  • Efficacy and safety of sequential hybrid therapy with pulmonary endarterectomy and additional balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension
    谷仲 謙一, Nakayama Kazuhiko, Shinke Toshiro, Otake Hiromasa, 鳥羽 敬義, 高橋 八大, 寺下 大輔, 新倉 悠人, 黒田 浩史, 宇津 賢三, 田原 奈津子, 長澤 圭典, 永野 雄一朗, 玉田 直己, 山本 裕之, 築山 義朗, Okita Yutaka, 江本 憲昭, Hirata Ken-ichi
    Transcatheter Cardiovascular Therapeutics (TCT 2016), Oct. 2016, English, Cardiovascular Research Foundation（CRF）, ワシントンDC, 米国, International conference
    Oral presentation

  • 経皮的心房中隔欠損閉鎖術前後における両心室間の相互作用と心拍出量増加について
    羽渓優, Tanaka Hidekazu, 高田裕基, 曽我文隆, 畑澤圭子, 松添弘樹, 下浦広之, 大岡順一, 佐野浩之, 郡山恵子, Matsumoto Kensuke, Otake Hiromasa, Shinke Toshiro, Hirata Ken-ichi
    The 121th Annual Scientific Meeting of the Kinki Regional Office of the Japanese Circulation Society, Jul. 2016, Japanese, Kinki Regional Office of the Japanese Circulation Society, 京都, 【目的】経皮的心房中隔欠損閉鎖術（ASO）後の両心室の変化と、左室の心拍出量増加に寄与する因子が何であるかを検討すること。【方法】対象はASOが施行された心房中隔欠損症70例。術前および術後3ヶ月に左室心筋機能の評価として、global longitudinal strainとLV dispersion（左室収縮のばらつき）を、右室収縮能指標としてRV free-wall strainを算出した。【結果】ASO後にRV free-wall strainは有意に低下し、LV dispersionは有意に低下した。多変量解析ではRV free-wall strainの変化率とLV dispersionの変化率が、ASO後の左室心拍出量の増加に寄与する独立した規定因子であった。【結語】LV dispersionならびにRV free-wall strain, Domestic conference
    Oral presentation

  • プラークの不安定化に対する新規アプローチ-血行力学的評価の重要性-
    Otake Hiromasa
    Cardiovascular Interventionand Therapeuticsacientific meeting 2016(CVIT2016), Jul. 2016, Japanese, Japanese Association of Cardiovascular Intervention and Therapeutics, 東京, Domestic conference
    [Invited]
    Nominated symposium

  • Current status and future direction of OCT guided coronary intervention
    Shinke Toshiro, Otake Hiromasa, Hirata Ken-ichi
    Cardiovascular Interventionand Therapeuticsacientific meeting 2016(CVIT2016), Jul. 2016, Japanese, Japanese Association of Cardiovascular Intervention and Therapeutics, 東京, Domestic conference
    Others

  • Bi-ventricular Interaction in Patients with Atrial Septal Defect Following Transcatheter Closure
    Yutaka Hatani, Tanaka Hidekazu, Takuma Sawa, Keiko Hatazawa, Kumiko Dokuni, Hiroki Matsuzoe, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Yoshiki Motoji, Yasuhide Mochizuki, Keiko Ryo, Matsumoto Kensuke, Otake Hiromasa, Shinke Toshiro, Hirata Ken-ichi
    The 80th Annual Scientific Meeting of Japanese Circulation Socisty, Mar. 2016, Japanese, Japanese Circulation Society, 仙台, Background: Atrial septal defect (ASD) causes chronic volume overload on right-sided heart, but the potential adverse effects of this long-standing volume overload to left ventricle as well as the response to ASD closure remains unclear. Methods: Fifty-th, Domestic conference
    Oral presentation

  • Clinical feature of post operative pulmonary hypertension in congenital heart disease
    Nakayama Kazuhiko, 鈴木陽子, 新倉悠人, 玉田直己, 谷仲謙一, Matsumoto Kensuke, Tanaka Hidekazu, Otake Hiromasa, Shinke Toshiro, Hirata Ken-ichi, 江本憲昭
    第18回日本成人先天性心疾患学会学術集会, Jan. 2016, Japanese, 日本成人先天性心疾患学会 (JSACHD), 大阪, Domestic conference
    Public symposium

  • Bi-ventricular Interaction in Patients with Atrial Septal Defect Following Transcatheter Closure
    羽渓優, Tanaka Hidekazu, 佐和琢磨, 高田裕基, 曽我文隆畑澤圭子, 松添弘樹, 下浦広之, 大岡順一, 佐野浩之, 望月泰秀, 漁恵子, Matsumoto Kensuke, Otake Hiromasa, Shinke Toshiro, Hirata Ken-ichi
    The 18th Annual Meeting of Japanese Society for Adult Congenital Heart Disease, Jan. 2016, Japanese, Japanese Society for Adult Congenital Heart Disease, 大阪, Background: Atrial septal defect (ASD) causes chronic volume overload on right-sided heart, but the potential adverse effects of this long-standing volume overload to left ventricle as well as the response to ASD closure remains unclear. Methods: We studi, Domestic conference
    Poster presentation

  • Utility of Isovolumic Contraction Peak Velocity for Evaluation of Adult Patient Status after Transcatheter Closure of Atrial Septal Defect
    佐和 琢磨, Matsumoto Kensuke, Tanaka Hidekazu, Hirata Ken-ichi, Mana Hiraishi, Yoshiki Motoji, Yasuhide Mochizuki, Keiko Ryo, Otake Hiromasa, Shinke Toshiro, Hirata Ken-ichi
    The 18th Annual Meeting of Japanese Society for Adult Congenital Heart Disease, Jan. 2016, Japanese, Japanese Society for Adult Congenital Heart Disease, 大阪, Background: Prognostic factors after transcatheter closure for adult patients with atrial septal defect (ASD) have not been fully identified. Methods: Forty-nine patients who underwent transcatheter ASD closure were recruited for this study. Echocardiogra, Domestic conference
    Oral presentation

  • All bout FFRCT:FFRCTはGame Changerになりうるか
    Otake Hiromasa
    The 26th Japanese Society of Cardiovascular Imaging&Dynamics, Jan. 2016, Japanese, Japanese Society of Cardiovascular Imaging&Dynamics, 東京, Domestic conference
    [Invited]
    Nominated symposium

  • The impact of in-stent neoatherosclerosis on long-term clinical outcomes: an observational study from the optical coherence tomography registry
    黒田優, Otake Hiromasa, Shinke Toshiro, Takaya Tomofumi, 大末剛史, 絹谷洋人, 小西明英, 高橋八大, 寺下大輔, Hirata Ken-ichi
    EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2015(ESC 2015), Aug. 2015, English, European Society of Cardiology, ロンドン, 英国, International conference
    Poster presentation

  • Appropriateness of coronary intervention in terms of clinical presentation and symptoms
    Shinke Toshiro, Otake Hiromasa, Hirata Ken-ichi
    Cardiovascular Interventionand Therapeuticsacientific meeting 2015, Jul. 2015, Japanese, Japanese Association of Cardiovascular Intervention and Therapeutics, 福岡, Domestic conference
    [Invited]
    Nominated symposium

  • 新しい半導体システム D-SPECTの有用性
    Takaya Tomofumi, 藤原征, 伊藤達郎, Otake Hiromasa, Shinke Toshiro, Hirata Ken-ichi
    第24回日本心血管インターベンション治療学会, Jul. 2015, Japanese, 日本心血管インターベンション治療学会, 福岡, Domestic conference
    Public symposium

  • The Impact of Plaque Characteristics on Visual-functional Mismatch assessed by OCT, IVUS, and FFR
    Otake Hiromasa
    Cardiovascular Interventionand Therapeuticsacientific meeting 2015(CVIT2015), Jul. 2015, Japanese, Japanese Association of Cardiovascular Intervention and Therapeutics, 福岡, Domestic conference
    [Invited]
    Nominated symposium

  • The Assessment of Exercise Tolerance and Oxygenation after Balloon Pulmonary Angioplasty for Inoperable Chronic Thromboembolic Pulmonary Hypertension Patients
    Hiroto Kinutani, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Tsuyoshi Osue, Akihide Konishi, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Daiji Kashiwagi, Koji Kuroda, Natsuko Tahara, Yoshinori Nagawsawa, Noriaki Emoto, Nakayama Kazuhiko, Yu Taniguchi, Yuto Shinkura, Hirata Ken-ichi
    第79回日本循環器学会総会, Apr. 2015, English, 日本循環器学会, 大阪, Domestic conference
    Poster presentation

  • Four top reasons to use OCT during PCI
    Otake Hiromasa
    2015 The 79th Annual Scientific Meeting of the Japanese Circulation Society., Apr. 2015, Japanese, Japanese Societyof Cardiology, 大阪, Domestic conference
    Public symposium

  • High Perfusion Pressure as a Predictor of Reperfusion Pulmonary Injury after Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension
    Hiroto Kinutani, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Tsuyoshi Osue, Akihide Konishi, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Daiji Kashiwagi, Koji Kuroda, Natsuko Tahara, Yoshinori Nagawsawa, Noriaki Emoto, Nakayama Kazuhiko, Yu Taniguchi, Yuto Shinkura, Hirata Ken-ichi
    ACC.15 64th Annual Scientific & Expo, Mar. 2015, English, American College of Cardiology, San Diego, US, International conference
    Poster presentation

  • The predictors and clinical impact of neoatherosclerosis after drug-eluting stent
    Shinke Toshiro, Masaru Kuroda, Otake Hiromasa, Hirata Ken-ichi
    The 11th Annual Scientific Meeting of KOREAN SOCIETY OF INTERVENTIONAL CARDIOLOGY, Jan. 2015, English, Korean Society of Interventional Cardiology, 済州島, 韓国, International conference
    [Invited]
    Nominated symposium

  • OCT/OFDIを用いた新時代の冠動脈インターベンション
    Shinke Toshiro, Takaya Tomofumi, Otake Hiromasa, Hirata Ken-ichi
    The 25th Japanese Society of Cardiovascular Imaging&Dynamics, Jan. 2015, Japanese, Japanese Society of Cardiovascular Imaging&Dynamics, 東京, Domestic conference
    [Invited]
    Nominated symposium

  • 慢性血栓塞栓性肺高血圧症に対する血栓内膜摘除術とバルーン肺動脈形成術のハイブリッド治療にて良好な結果を得られた一例
    o Kinutani, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Noriaki Emoto, Nakayama Kazuhiko, Yu Taniguchi, Yuto Shinkura, Hirata Ken-ichi, Yutaka Ohkita, Okada Kenji
    ストラクチャージャパン ライブデモンストレーション2014, Nov. 2014, Japanese, ストラクチャージャパン, 東京, Domestic conference
    Oral presentation

  • The authors have no financial conflicts of interest to disclose concerning the presentation
    寺下 大輔, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Tanaka Hidekazu, 元地 由樹, 絹谷 洋人, 小西 明英, 佐和 琢磨, 黒田 優, 高橋 八大, 志手 淳也, Hirata Ken-ichi
    The 62nd Annual ScientificSession of the JapaneseCollege of Cardiology, Sep. 2014, English, Japanese College of Cardiology, 仙台, Domestic conference
    Oral presentation

  • ステントプラットフォームがステント留置後血管内ずり応力に与える影響
    Otake Hiromasa
    The 62nd Annual ScientificSession of the JapaneseCollege of Cardiology, Sep. 2014, Japanese, Japanese College of Cardiology, 仙台, Domestic conference
    [Invited]
    Nominated symposium

  • The Impact of Final Kissing Balloon Inflation on Vessel Healing Following Drug-eluting Stent Implantation: Insight from the Optical Coherence Tomography Sub-study of J-REVERSE Trial
    Hachidai Takahashi, Shinke Toshiro, Otake Hiromasa, Yoshinobu Murasato, Yoshihisa Kinoshita, Masahiro Yamawaki, Yoshihiro Takeda, Ken-ichi Fujii, Shin-ichiro Yamada, Yoshihisa Shimada, TakehiroYamashita, Kazuhiko Yumoto, Hirata Ken-ichi
    European Society of Cardiology2014, Aug. 2014, English, European Society of Cardiology, バルセロナ, スペイン, International conference
    Poster presentation

  • Reduced benefit of final kissing balloon inflation after single stenting to bifurcation lesions in patients with diabetes : Insight from the optical coherence tomography sub-study of J-REVERSE trial
    Shinke Toshiro, Otake Hiromasa, Yoshinobu Murasato, Yoshihisa Kinoshita, Masahiro Yamawaki, YoshihiroTakeda, Ken-ichi Fujii, Shin-ichiroYamada, Yoshihisa Shimada, TakehiroYamashita, Kazuhiko Yumoto, Hiroto Kinutani, Daisuke Terashita, Hachidai Takahashi, Hirata Ken-ichi
    European Society of Cardiology2014, Aug. 2014, English, European Society of Cardiology, バルセロナ, スペイン, International conference
    Poster presentation

  • Lower On-treatment Platelet Reactivity at the Time of Stent Placement Contributes to the Resolution of Post-procedural Intra-stent Thrombus: Serial OCT Observation in PRASFIT-Elective
    Masamichi Iwasaki, Shinke Toshiro, Otake Hiromasa, Hirata Ken-ichi, Shigeru Saito, Masato Nakamura, Junya Shite, Takashi Akasaka
    European Society of Cardiology2014, Aug. 2014, English, European Society of Cardiology, バルセロナ, スペイン, International conference
    Poster presentation

  • Difference of Vessel Healings between Sirolimus- and Everolimus-eluting Stent Implantation in Bifurcation Lesions: from J-REVERSE OCT Sub-study
    Daisuke Terashita, Shinke Toshiro, Otake Hiromasa, Yoshinobu Murasato, Yoshihisa Kinoshita, Masahiro Yamawaki, Yoshihiro Takeda, Ken-ichi Fujii, Shin-ichiro Yamada, Yoshihisa Shimada, Takehiro Yamashita, Kazuhiko Yumoto, Hiroto Kinutani, Hachidai Takahashi, Hirata Ken-ichi
    European Society of Cardiology2014, Aug. 2014, English, European Society of Cardiology, バルセロナ, スペイン, International conference
    Poster presentation

  • Lower On-treatment Platelet Reactivity during Stent Placement Contributes to the Resolution of Post-procedural Intra-stent Thrombus
    Masamichi Iwasaki, Shinke Toshiro, Otake Hiromasa, Hirata Ken-ichi, Shigeru Saito, Masato Nakamura, Junya Shite, Takashi Akasaka
    Cardiovascular Interventionand Therapeuticsacientific meeting 2014, Jul. 2014, English, 日本心血管インターベンション治療学会, 名古屋, Domestic conference
    Public symposium

  • Angiographic Band Appearance is Associated with Smaller Reduction of Pressure Gradient Following Balloon Pulmonary Angioplasty for Chronic Thromboembolic Hypertension
    Hiroto Kinutani, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Masayuki Nakagawa, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Akihide Konishi, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Noriaki Emoto, Nakayama Kazuhiko, Kazuya Miyagawa, Hirata Ken-ichi
    CVIT 2014, Jul. 2014, Japanese, Japanese Association of Cardiovascular Intervention and Therapeutics, 名古屋, Domestic conference
    Oral presentation

  • Role of OCT in PCI for bifurcation lesion
    Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Hirata Ken-ichi
    Cardiovascular Interventionand Therapeuticsacientific meeting 2014, Jul. 2014, Japanese, 日本心血管インターベンション治療学会, 名古屋, Domestic conference
    Public symposium

  • OCT evaluation for drug-eluting stent andbioresorbable vascular scaffold
    Otake Hiromasa, 新家 敏郎, Hirata Ken-ichi
    Cardiovascular Interventionand Therapeuticsacientific meeting 2014, Jul. 2014, Japanese, 日本心血管インターベンション治療学会, 名古屋, Domestic conference
    Oral presentation

  • The impact of atherogenic neointima on long-termclinical outcome
    Otake Hiromasa, 新家 敏郎, 黒田 優, Hirata Ken-ichi
    Cardiovascular Interventionand Therapeuticsacientific meeting 2014, Jul. 2014, Japanese, 日本心血管インターベンション治療学会, 名古屋, Domestic conference
    Oral presentation

  • The Mid-term Outcome of Transcatheter Closure of Atrial Septal Defect in the elderly
    Daisuke Terashita, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Tanaka Hidekazu, Tsuyoshi Osue, Yoshiki Motoji, Hiroto Kinutani, Akihide Konishi, Takuma Sawa, Masaru Kuroda, Hachidai Takahashi, Junya Shite, Hirata Ken-ichi
    Cardiovascular Interventionand Therapeuticsacientific meeting 2014, Jul. 2014, English, 日本心血管インターベンション治療学会, 名古屋, Domestic conference
    Oral presentation

  • The Impact of Final Kissing Balloon Inflation on Vessel Healing Following Drug-eluting Stent Implantation: Insight from the Optical Coherence Tomography Sub-study of J-REVERSE Trial
    Hachidai Takahashi, Shinke Toshiro, Otake Hiromasa, Yoshinobu Murasato, Yoshihisa Kinoshita, Masahiro Yamawaki, Yoshihiro Takeda, Ken-ichi Fujii, Shin-ichiro Yamada, Yoshihisa Shimada, Takehiro Yamashita, Kazuhiko Yumoto, Hirata Ken-ichi
    Cardiovascular Interventionand Therapeuticsacientific meeting 2014, Jul. 2014, English, 日本心血管インターベンション治療学会, 名古屋, Domestic conference
    Oral presentation

  • Arterial Reactions 2-Week after 2nd-generation Drug-Eluting and Bare-Metal Stents implantation in ST-Segment Elevation Myocardial Infarction Patients: MECHANISM pilot OCT study
    Ryo Nishio, Shinke Toshiro, Yoshihiro Morino, Kengo Tanabe, Jungo Furuya, Kaname Takizawa, Junya Ako, Ken Kozuma, Kiyoshi Hibi, Hideki Ishii, Atsushi Hirohata, Yoritaka Otsuka, Otake Hiromasa, Takaya Tomofumi, Hirata Ken-ichi
    Cardiovascular Interventionand Therapeuticsacientific meeting 2014, Jul. 2014, English, 日本心血管インターベンション治療学会, 名古屋, Domestic conference
    Public symposium

  • Imaging Guided PCI : Procedure with more efficiencyand safetyHow can OCT help PCI procedure and improve patients' outcome?
    Shinke Toshiro, Otake Hiromasa, Hirata Ken-ichi
    Cardiovascular Interventionand Therapeuticsacientific meeting 2014, Jul. 2014, Japanese, 日本心血管インターベンション治療学会, 名古屋, Domestic conference
    Public symposium

  • Impact of Underneath Plaque Characteristics on the Fate of Acute Incomplete Strut Apposition: Serial Optical Coherence
    Masayuki Nakagawa, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Hiroto Kinutani, Akihide Konishi, Masaru Kuroda, Takashi Kubo, Hiroyuki Okura, Kyouichi Mizuno, Hirata Ken-ichi, Takashi Akasaka, Hiroyoshi Yokoi, Toshiya Muramatsu, Masato Nakamura, Shinsuke Nanto
    Cardiovascular Interventionand Therapeuticsacientific meeting 2014, Jul. 2014, English, 日本心血管インターベンション治療学会, 名古屋, Domestic conference
    Oral presentation

  • Impact of Vessel Reactions to Stent Deployment onMid-term Vascular Healing: Serial Optical Coherence Tomography Study after Everolimus-eluting Stent Implantation
    Masamichi Iwasaki, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Tsuyoshi Osue, Yu Taniguchi, Ryo Nishio, Akihide Konishi, Hiroto Kinutani, Masaru Kuroda, HachidaiTakahash, DaisukeTerashita, Hirata Ken-ichi
    Cardiovascular Interventionand Therapeuticsacientific meeting 2014, Jul. 2014, English, 日本心血管インターベンション治療学会, 名古屋, Domestic conference
    Oral presentation

  • Angiographic Band Appearance is Associated with Smaller Reduction of Pressure Gradient Following Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension
    Hiroto Kinutani, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Masayuki Nakagawa, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Akihide Konishi, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Noriaki Emoto, Nakayama Kazuhiko, Kazuya Miyagawa, Hirata Ken-ichi
    Cardiovascular Interventionand Therapeuticsacientific meeting 2014, Jul. 2014, Japanese, 日本心血管インターベンション治療学会, 名古屋, Domestic conference
    Poster presentation

  • Tissue characteristics of jailed strut following single stenting to bifurcation lesions: Optical coherence tomography assessment among four drug-eluting stents
    Terashita Hachidai, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Masayuki Nakagawa, Ryo Nishio, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Akihide Konishi, Hiroto Kinutani, Masaru Kuroda, Daisuke Takahashi, Hirata Ken-ichi
    日本循環器学会, Mar. 2014, English, Japanese Society of Cardiology, 東京, Domestic conference
    Oral presentation

  • The impact of atherogenic neointima on long-term clinical outcomes: an observational study from the optical coherence tomography registry
    Masaru Kuroda, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Masayuki Nakagawa, Ryo Nishio, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Akihide Konishi, Hiroto Kinutani, Daisuke Terashita, Hachidai Takahashi, Hirata Ken-ichi
    日本循環器学会, Mar. 2014, English, Japanese Society of Cardiology, 東京, Domestic conference
    Oral presentation

  • Long-term Clinical Impact of Thin-cap Fibroatheroma Assessed by Optical Coherence Tomography and Virtual Histology Intravascular Ultrasound Analysis.
    Daisuke Terashita, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Masayuki Nakagawa, Ryo Nishio, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Akihide Konishi, Hiroto Kinutani, Masaru Kuroda, Hachidai Takahashi, Hirata Ken-ichi
    ACC2014, Mar. 2014, English, American College of Cardiology, ワシントン, 米国, International conference
    Poster presentation

  • Improvement of Cardiac Output after Balloon Pulmonary Angioplasty Depends on Preoperative Right Ventricular Function in inoperable Chronic Thromboembolic Pulmonary Hypertension
    Taniguchi Yu, EmotoNoriaki, Terashita Daisuke, Takahashi Hachidai, Kuroda Masaru, Konishi Akihide, Kinutani Hiroto, Nishio Ryo, Iwasaki Masamichi, Osue Tsuyoshi, Nakagawa Masayuki, Takaya Tomofumi, Otake Hiromasa, Shinke Toshiro, Hirata Ken-ichi
    第78回日本循環器学会総会, Mar. 2014, English, The Japanese Circulation Society, 東京, Domestic conference
    Poster presentation

  • Impact of Stent-platform on Wall Shear Stress Distributions:Insights from Computational Fluid Dynamics Simulations Using OCT and CTA Fusion Images
    Otake Hiromasa, Shinke Toshiro, Masayuki Nakagawa, Ryo Nishio, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Akihide Konishi, Hiroto Kinutani, Masaru Kuroda, Hirata Ken-ichi
    日本循環器学会, Mar. 2014, Japanese, Japanese Society of Cardiology, 東京, Domestic conference
    Public symposium

  • Impact of Daily Glucose Fluctuation on Coronary Plaque Vulnerability in Patients Pretreated With Lipid Lowering Therapy
    Shinke Toshiro, Masaru Kuroda, Otake Hiromasa, Takaya Tomofumi, Masayuki Nakagawa, Takumi Inoue, Ryo Nishio, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Akihide Konishi, Hiroto Kinutani, Daisuke Terashita, Hachidai Takahashi, Hirata Ken-ichi
    Annual Ascientific session of Japanese Society of Cardiology, Mar. 2014, Japanese, Japanese Society of Cardiology, 東京, Domestic conference
    Public symposium

  • Impact of Daily Glucose Fluctuation on Coronary Plaque Vulnerability in Patients Pretreated With Lipid Lowering Therapy
    Masaru Kuroda, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Masayuki Nakagawa, Ryo Nishio, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Akihide Konishi, Hiroto Kinutani, Daisuke Terashita, Hachidai Takahashi, Hirata Ken-ichi
    ACC2014, Mar. 2014, English, American College of Cardiology, ワシントン, 米国, International conference
    Poster presentation

  • Favorable Vessel Healing after Nobori Biolimus A9 Eluting Stent Implantation: 6- and 12-month Follow-up by Optical Coherence Tomography
    Akihide Konishi, Shinke Toshiro, Otake Hiromasa, Daisaku Nakatani, Takaya Tomofumi, Masayuki Nakagawa, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Hiroto Kinutani, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Hirata Ken-ichi
    日本循環器学会, Mar. 2014, English, Japanese Society of Cardiology, 東京, Domestic conference
    Poster presentation

  • Comparisons of Early Phase Arterial Reaction after 2nd generation Drug-Eluting and Bare-Metal Stents Implantation in Patients with ST-Segment Elevation Myocardial Infarction: 2-Week Observations of Optical Coherence Tomography Evaluation
    Ryo Nishio, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Masayuki Nakagawa, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Akihide Konishi, Hiroto Kinutani, Masaru Kuroda, Daisuke Terashita, Hachidai Takahashi, Hirata Ken-ichi
    ACC2014, Mar. 2014, English, American College of Cardiology, ワシントン, 米国, International conference
    Poster presentation

  • 慢性肺血栓塞栓症 (CTEPH)治療におけるバルーン肺動脈形成術 (BPA)の位置づけと治療手技の実際
    Shinke Toshiro, 谷口 悠, 絹谷 洋人, 宮川 一也, Takaya Tomofumi, Nakayama Kazuhiko, Otake Hiromasa, 江本 憲昭, Hirata Ken-ichi, Okada Kenji, Okita Yutaka
    日本肺高血圧学会, Oct. 2013, Japanese, 日本肺高血圧学会, 東京, Domestic conference
    Public symposium

  • Everolimus-eluting stent留置直後のOCT所見とTroponin I上昇との関連、ならびに留置9か月後における新生内膜被覆への影響の検討
    岩崎正道, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, 中川雅之, 大末剛史, 谷口悠, 西尾亮, 小西明英, 絹谷洋人, 黒田優, 高橋八大, 寺下大輔, Hirata Ken-ichi
    日本心血管内視鏡学会, Oct. 2013, Japanese, 日本心血管内視鏡学会, 久留米, Domestic conference
    Oral presentation

  • Efficacy and Safety of Balloon Pulmonary Angioplasty for Non-operable Chronic Thromboembolic Pulmonary Hypertension in Comparison to Pulmonary Endarterectomy for Operable Patients
    Yu Taniguchi, Noriaki Emoto, Hiroto Kinutani, Otake Hiromasa, Shinke Toshiro, Hirata Ken-ichi
    TCT(Transcatheter Cardiovascular Therapeutics) 2013, Oct. 2013, English, Cardiovascular Research Foundation, サンフランシスコ, 米国, International conference
    Oral presentation

  • 慢性血栓塞栓性肺高血圧症に対する薬物治療と経皮的肺動脈バルーン形成術の治療効果の検討
    谷口 悠, Shinke Toshiro, 絹谷 洋人, 宮川 一也, Nakayama Kazuhiko, Otake Hiromasa, 江本 憲昭, Hirata Ken-ichi, Okada Kenji, Okita Yutaka
    第61回心臓病学会, Sep. 2013, Japanese, Japanese College of Cardiology, 熊本, Domestic conference
    Oral presentation

  • 慢性血栓塞栓性肺高血圧症に対する 肺動脈カテーテル形成術と血栓内膜摘除術の比較
    谷口悠, 江本憲昭, 絹谷洋人, 宮川一也, Otake Hiromasa, Shinke Toshiro, Hirata Ken-ichi, Okada Kenji, Okita Yutaka
    日本心臓病学会, Sep. 2013, Japanese, 日本心臓病学会, 熊本, Domestic conference
    Oral presentation

  • Impact of Hemodialysis on Vessel Healing after Drug-eluting Stent Implantation
    Akihide Konishi, Shinke Toshiro, Otake Hiromasa, Daisaku Nakatani, Takaya Tomofumi, Masayuki Nakagawa, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Hiroto Kinutani, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Hirata Ken-ichi
    日本心臓病学会, Sep. 2013, Japanese, 日本心臓病学会, 熊本, Domestic conference
    Public symposium

  • The Evaluation of Efficacy and Safety of Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension
    Yu Taniguchi, Shinke Toshiro, Hiroto Kinutani, Otake Hiromasa, Takaya Tomofumi, Masayuki Nakagawa, Ryo Nishio, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Masamichi Iwasaki, Akihide Konishi, Masaru Kuroda, Daisuke Terashita, Hachidai Takahashi, Nakayama Kazuhiko, Kazuya Miyagawa, Noriaki Emoto, Hirata Ken-ichi
    European Society of Cardiology meeting 2013, Aug. 2013, English, European Society of Cardiology, アムステルダム, オランダ, International conference
    Oral presentation

  • Impact of Strut-vessel Distance on the persistent Incomplete Strut Apposition: Serial Optimal Coherence Tomography Analysis After 1st-generation and Everolimus-eluting Stent Stent
    Takumi Inoue, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryo Nishio, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Akihide Konishi, Hiroto Kinutani, Masaru Kuroda, Hirata Ken-ichi
    European Society of Cardiology meeting 2013, Aug. 2013, English, European Society of Cardiology, アムステルダム, オランダ, International conference
    Poster presentation

  • Hemodynamic Improvement through Beneficial Vessel Reaction Following Balloon Pulmonary Angioplasty for Distal-type Chronic Thromboembolic Pulmonary Hypertension
    Hiroto Kinutani, Toshiro Shinke, Hiromasa Otake, TomofumiTakaya, Masayuki Nakagawa, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Akihide Konishi, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Noriaki Emoto, Kazuhiko Nakayama, Kazuya Miyagawa, Ken-ichi Hirata
    European Society of cardiology 2013, Aug. 2013, English, European Society of Cardiology, アムステルダム, オランダ, International conference
    Poster presentation

  • Efficacy and safety of balloon pulmonary angioplasty for inoperable patients with peripheral type chronic thromboembolic pulmonary hypertension
    Y. Taniguchi, Shinke Toshiro, H. Kinutani, Otake Hiromasa, N. Emoto, Hirata Ken-ichi
    European Society of cardiology 2013, Aug. 2013, English, European Society of Cardiology, アムステルダム, オランダ, International conference
    Oral presentation

  • Daily Glucose Profile Has an Impact on Coronary Plaque Character in Patients with Coronary Artery Disease
    Masaru Kuroda, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Masayuki Nakagawa, Ryo Nishio, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Akihide Konishi, Hiroto Kinutani, Daisuke Terashita, Hachidai Takahashi, Hirata Ken-ichi
    European Society of Cardiology meeting 2013, Aug. 2013, English, European Society of Cardiology, アムステルダム, オランダ, International conference
    Poster presentation

  • The Evaluation of Vascular Remodeling Following Balloon Pulmonary Angioplasty for Distal-type Thromboemboric Pulmonary Hypertension
    Hiroto Kinutani, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Masayuki Nakagawa, Ryo Nishio, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Akihide Konishi, Masaru Kuroda, Daisuke Terashita, Hachidai Takahashi, Kazuya Miyagawa, Noriaki Emoto, Hirata Ken-ichi
    Cardiovascular Intervention and Therapeutics acientific meeting 2013, Jul. 2013, English, 日本心血管インターベンション治療学会, 神戸, Domestic conference
    Poster presentation

  • Neoatherosclerosis within Sirolimus-eluting Stent may Reflect the Extent of Atherosclerotic Progression in Patient with Coronary Artery Disease
    Masaru Kuroda, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Masayuki Nakagawa, Ryo Nishio, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Akihide Konishi, Hiroto Kinutani, Daisuke Terashita, Hachidai Takahashi, Hirata Ken-ichi
    Cardiovascular Intervention and Therapeutics acientific meeting 2013, Jul. 2013, English, 日本心血管インターベンション治療学会, 神戸, Domestic conference
    Poster presentation

  • Impact of Strut-vessel Distance and Plaque Characteristics on the Persistent Incomplete Strut Apposition: Serial OCT Analysis After DES Implantation
    Takumi Inoue, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryo Nishio, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Akihide Konishi, Hiroto Kinutani, Masaru Kuroda, Hirata Ken-ichi
    Cardiovascular Intervention and Therapeutics acientific meeting 2013, Jul. 2013, English, 日本心血管インターベンション治療学会, 神戸, Domestic conference
    Oral presentation

  • Impact of cytochrome P450 2C19 polymorphism and residual platelet reactivity on lesion outcome after 1st and New Generation drug-Eluting Stent
    Shinke Toshiro, Akihide Konishi, Otake Hiromasa, Takaya Tomofumi, Masayuki Nakagawa, Takumi Inoue, Ryo Nishio, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Hiroto Kinutani, Masaru Kuroda, Daisuke Terashita, Hachidai Takahashi, Hirata Ken-ichi
    Cardiovascular Intervention and Therapeutics acientific meeting 2013, Jul. 2013, English, 日本心血管インターベンション治療学会, 神戸, Domestic conference
    Public symposium

  • Favorable Vessel Healing after Nobori Biolimus A9 Eluting Stent Implantation 6- and 12-month Follow-up by Optical Coherence Tomography
    Akihide Konishi, Shinke Toshiro, Otake Hiromasa, Takaya Tomofumi, Masayuki Nakagawa, Ryo Nishio, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Hiroto Kinutani, Masaru Kuroda, Daisuke Terashita, Hachidai Takahashi, Hirata Ken-ichi
    Cardiovascular Intervention and Therapeutics acientific meeting 2013, Jul. 2013, English, 日本心血管インターベンション治療学会, 神戸, Domestic conference
    Oral presentation

  • 慢性肺血栓塞栓症と鑑別が困難であった原発性肺血管肉腫の一例
    絹谷 洋人, 江本 憲昭, Nakayama Kazuhiko, 谷口 悠, Shinke Toshiro, Otake Hiromasa, Hirata Ken-ichi
    第2回日本肺循環学会学術集会, Jun. 2013, Japanese, Japanease Pulmonary Circulation Society, 東京, Domestic conference
    Oral presentation

  • 持続血糖モニタリングにて判明した胃切除後血糖変動が誘因の一つと考えられた急性冠症候群の一例
    黒田優, Shinke Toshiro, Sakaguchi Kazuhiko, Yamashita Tomoya, Otake Hiromasa, Hirota Yushi, 西尾亮, Hirata Ken-ichi
    Scientific session of Japanese Society of Internal Medicine, Apr. 2013, Japanese, Japanese Society of Internal Medicine, 東京, Domestic conference
    Oral presentation

  • Temporal Course of Vessel Healing after Everolimus-eluting Stent Implantation
    Otake Hiromasa, Shinke Toshiro, Masayuki Nakagawa, Ryo Nishio, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Akihide Konishi, Hiroto Kinutani, Masaru Kuroda, Hirata Ken-ichi
    Scientific session of Japanese Society of Internal Medicine, Apr. 2013, Japanese, Japanese Society of Internal Medicine, 東京, Domestic conference
    Poster presentation

  • 慢性透析患者における血清P値と大動脈弁狭窄症の関連についての検討
    Ryo Nishio, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Tsuyoshi Osue, Takumi Inoue, Masamichi Iwasaki, Yu Taniguchi, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    Scientific session of Japanese Circulation Society, Mar. 2013, Japanese, Japanese Circulation Society, 横浜, International conference
    Poster presentation

  • Use of Coronary CT Angiography to Assess Plaque Vulnerability: A Direct Comparison to Optical Coherence Tomography
    Akihide Konishi, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Tsuyoshi Osue, Takumi Inoue, Ryo Nishio, Masamichi Iwasaki, Yu Taniguchi, Noritoshi Hiranuma, Hirotoshi Hariki, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    Scientific session of Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, International conference
    Oral presentation

  • The ralataionships between plaque vulnerability identified by optical coherence tomography and vascular dysfunction after stent implantation
    Tsuyoshi Osue, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Masamichi Iwasaki, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    Scientific session of Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, International conference
    Poster presentation

  • The ralataionships between plaque vulnerability identified by optical coherence tomography and vascular dysfunction after stent implantation
    Tsuyoshi Osue, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Masamichi Iwasaki, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    Scientific session of American College of Cardiology, Mar. 2013, English, American College of Cardiology, サンフランシスコ, International conference
    Poster presentation

  • Temporal course of vessel healing after everolimus-eluting stent implantation: Long term serial follow-up by optical coherence tomography
    Yu Taniguchi, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Hirotoshi Hariki, Tsuyoshi Osue, Takumi Inoue, Masamichi Iwasaki, Ryo Nishio, Hiroto Kinutani, Akihide Konishi, Noritoshi Hiranuma, Masaru Kuroda, Junya Shite, Hirata Ken-ichi
    Scientific session of Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, International conference
    Poster presentation

  • Temporal Course of Vessel Healing after Everolimus-eluting Stent Implantation
    Otake Hiromasa, Shinke Toshiro, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Tsuyoshi Osue, Takumi Inoue, Ryo Nishio, Masamichi Iwasaki, Yu Taniguchi, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    Scientific session of Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, International conference
    Oral presentation

  • Temporal Course of Vessel Healing after Everolimus-eluting Stent Implantation
    Ryo Nishio, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Tsuyoshi Osue, Takumi Inoue, Masamichi Iwasaki, Yu Taniguchi, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    Scientific session of American College of Cardiology, Mar. 2013, English, American College of Cardiology, サンフランシスコ, International conference
    Oral presentation

  • Prevalence and Determinants of Intra-Stent Thrombus after Everolimus-Eluting Stent Implantation Assessed by Angioscopy and Optical Coherence Tomography
    Masamichi Iwasaki, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Masaru Kuroda, Junya Shite
    Scientific session of Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, International conference
    Poster presentation

  • Prevalence and Determinants of Intra-Stent Thrombus after Everolimus-Eluting Stent Implantation Assessed by Angioscopy and Optical Coherence Tomography
    Masamichi Iwasaki, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Masaru Kuroda, Junya Shite
    Scientific session of American College of Cardiology, Mar. 2013, English, American College of Cardiology, サンフランシスコ, International conference
    Poster presentation

  • Paraoxonase-1 activity is associated with clopidogrel response and intra-stent thrombus after drug-eluting stent implantation in the CYP2C19 loss-of-function polymorphism carriers
    Ryo Nishio, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Tsuyoshi Osue, Takumi Inoue, Masamichi Iwasaki, Yu Taniguchi, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    Scientific session of Japanese Circulation Society, Mar. 2013, Japanese, Japanese Circulation Society, 横浜, International conference
    Poster presentation

  • Neoatherosclerosis within Sirolimus-eluting Stent (SES) may Reflect the Extent of Atherosclerotic Progression in Patient with Coronary Artery Disease
    Masaru Kuroda, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Tsuyoshi Osue, Takumi Inoue, Ryo Nishio, Masamichi Iwasaki, Yu Taniguchi, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    Scientific session of Japanese Circulation Society, Mar. 2013, Japanese, Japanese Circulation Society, 横浜, International conference
    Poster presentation

  • Impact of Strut-vessel Distance and Plaque Characteristics on Persistent Incomplete Strut Apposition:Serial Optimal Coherence Tomography Analysis after Everolimus-eluting Stent Implantation
    Takumi Inoue, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    Scientific session of Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, International conference
    Oral presentation

  • Impact of Strut-Vessel Distance and Plaque Characteristics on Persistent Incomplete Strut Apposition: Serial Optical Coherence Tomography Analysis after Everolimus-Eluting Stent Implantation
    Takumi Inoue, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    Scientific session of American College of Cardiology, Mar. 2013, English, American College of Cardiology, サンフランシスコ, International conference
    Poster presentation

  • Impact of eicosapentanoic acid and statin concomitant therapy on coronary thin-cap fibroatheroma: Assessment by optical coherence tomography
    Ryo Nishio, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Masamichi Iwasaki, Akihide Konishi, Junya Shite, Hirata Ken-ichi
    Scientific session of Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, International conference
    Poster presentation

  • Impact of cytochrome P450 2C19 polymorphism on drug-eluting stent failure in patients receiving clopidogrel: A potential role of paraoxonase-1 activity
    Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Tsuyoshi Osue, Takumi Inoue, Ryo Nishio, Masamichi Iwasaki, Yu Taniguchi, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    Scientific session of Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, International conference
    Public symposium

  • Impact of Cytochrome P450 2C19 Loss-of-Function Polymorphism on Intra-Stent Thrombus After 1st and New Generation Everolimus-Eluting Stent Implantation
    Akihide Konishi, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Tsuyoshi Osue, Takumi Inoue, Ryo Nishio, Masamichi Iwasaki, Yu Taniguchi, Noritoshi Hiranuma, Hirotoshi Hariki, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    Scientific session of Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, International conference
    Oral presentation

  • Comparisons of long-term arterial healing between sirolimus-eluting stent and paclitaxel-eluting stent: Detailed analysis by optical coherence tomography
    Masayuki Nakagawa, Shinke Toshiro, Otake Hiromasa, Ryoji Nagoshi, Amane Kozuki, Tsuyoshi Osue, Takumi Inoue, Ryo Nishio, Masamichi Iwasaki, Yu Taniguchi, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    Scientific session of Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, International conference
    Oral presentation

  • Comparison of the timing of neoatherosclerosis development among bare metal stents, sirolimus-eluting stents, and paclitaxel-eluting stents
    Hirotoshi Hariki, Junya Shite, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Hirata Ken-ichi
    Scientific session of Japanese Circulation Society, Mar. 2013, English, Japanese Circulation Society, 横浜, International conference
    Oral presentation

  • Comparison of the timing of neoatherosclerosis development among bare metal stents, sirolimus-eluting stents, and paclitaxel-eluting stents
    Hirotoshi Hariki, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    Scientific session of American College of Cardiology, Mar. 2013, English, American College of Cardiology, サンフランシスコ, International conference
    Poster presentation

  • Paclitaxel-eluting stent留置後のOCT長期フォローアップ
    Masayuki Nakagawa, Shinke Toshiro, Otake Hiromasa, Ryoji Nagoshi, Amane Kozuki, Tsuyoshi Osue, Takumi Inoue, Ryo Nishio, Masamichi Iwasaki, Yu Taniguchi, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    日本画像動態学会年次学術集会, Jan. 2013, English, 日本画像動態学会, 東京, Domestic conference
    Oral presentation

  • Relationship between Optical Coherence Tomography (OCT), Intravascular Ultrasound Tomography (IVUS) and Pressure-Derived Fractional Flow Reserve
    Tsuyoshi Osue, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Masamichi Iwasaki, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    American Heart Association meeting, Nov. 2012, English, American Heart Association, シカゴ, International conference
    Poster presentation

  • Progression of Vessel Healing and Neoatherosclerosis After Sirolimus-Eluting Stent Implantation: Comparisons of Serial Optical Coherence Tomography Findings Between Mid-and Late-Phase Follow-Up
    Amane Kozuki, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Takumi Inoue, Tsuyoshi Osue, Masamichi Iwasaki, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    American Heart Association meeting, Nov. 2012, English, American Heart Association, シカゴ, International conference
    Poster presentation

  • Neoatherosclerosis within Sirolimus-Eluting Stent may Reflect the Extent of Atherosclerotic Progression in Patient with Coronary Artery Disease
    Masaru Kuroda, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Tsuyoshi Osue, Takumi Inoue, Ryo Nishio, Masamichi Iwasaki, Yu Taniguchi, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    American Heart Association meeting, Nov. 2012, English, American Heart Association, シカゴ, International conference
    Oral presentation

  • Impact of Eicosapentanoic Acid and Statin Therapy on Coronary Thin-cap Fibroatheroma: Assessment by Optical Coherence Tomography
    Ryo Nishio, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Tsuyoshi Osue, Takumi Inoue, Masamichi Iwasaki, Yu Taniguchi, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    American Heart Association meeting, Nov. 2012, English, American Heart Association, シカゴ, International conference
    Oral presentation

  • Impact of Cytochrome P450 2C19 loss-of-function polymorphism on Intra-Stent Thrombus After 1st and new generation everolimus eluting stent Implantation in patients Receiving Clopidogrel
    Akihide Konishi, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Tsuyoshi Osue, Takumi Inoue, Ryo Nishio, Masamichi Iwasaki, Yu Taniguchi, Noritoshi Hiranuma, Hirotoshi Hariki, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    American Heart Association meeting, Nov. 2012, English, American Heart Association, シカゴ, International conference
    Oral presentation

  • Detailed Investigation of Vascular Response between Patients with or without Diabetes Mellitus after Everolimus-eluting Stent Implantation; Optical Coherence Tomography Study
    Masamichi Iwasaki, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Tsuyoshi Osue, Takumi Inoue, Ryo Nishio, Yu Taniguchi, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    American Heart Association meeting, Nov. 2012, English, American Heart Association, シカゴ, International conference
    Poster presentation

  • Comparisons of Neointima Tissue Components Between Cases with Early and Late Target Lesion Revascularization After 1St Generation Drug-Eluting Stents Implantation
    Otake Hiromasa, Shinke Toshiro, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Tsuyoshi Osue, Takumi Inoue, Ryo Nishio, Masamichi Iwasaki, Yu Taniguchi, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Junya Shite, Hirata Ken-ichi
    American Heart Association meeting, Nov. 2012, English, American Heart Association, シカゴ, International conference
    Oral presentation

  • Efficacy and Safety of Balloon Pulmonary Angioplasty for Peripheral Type Chronic Thromboembolic Pulmonary Hypertension
    谷口悠, 江本憲昭, 絹谷洋人, Nakayama Kazuhiko, Otake Hiromasa, Shinke Toshiro, 志手淳也, Hirata Ken-ichi
    Transcatheter Cardiovascular Therapeutics (TCT) conference 2012, Oct. 2012, English, Transcatheter Cardiovascular Therapeutics (TCT) conference, Miami, International conference
    Poster presentation

  • 慢性血栓塞栓性肺高血圧症に対する肺動脈バルーン拡張術後の肺血管リモデリングの機能的・形態学的解析
    絹谷洋人, 江本憲昭, 谷口悠, Nakayama Kazuhiko, Otake Hiromasa, Shinke Toshiro, 志手淳也, Hirata Ken-ichi
    Japanese Pulmonary Circulation Society, 1st Scientific Meeting, Sep. 2012, Japanese, Japanese Pulmonary Society of Japan, 福岡, Domestic conference
    Oral presentation

  • 肺高血圧患者における、NICaS（全身バイオインピーダンス計測法）を用いた非侵襲的心拍出量評価方法の有用性
    谷口悠, 江本憲昭, 絹谷洋人, Nakayama Kazuhiko, Otake Hiromasa, Shinke Toshiro, 志手淳也, Hirata Ken-ichi
    Japanese Pulmonary Circulation Society, 1st Scientific Meeting, Sep. 2012, Japanese, Japanese Pulmonary Society of Japan, 福岡, Domestic conference
    Oral presentation

  • 心房中隔欠損症に伴う肺高血圧症に対する「treat & repair」アプローチ
    谷口悠, 江本憲昭, 絹谷洋人, Nakayama Kazuhiko, Otake Hiromasa, Shinke Toshiro, 志手淳也, Hirata Ken-ichi
    Japanese Pulmonary Circulation Society, 1st Scientific Meeting, Sep. 2012, Japanese, Japanese Pulmonary Society of Japan, 東京, Domestic conference
    Oral presentation

  • Relationship between Optical Coherence Tomography (OCT), Intravascular Ultrasound Tomography (IVUS) and Pressure-Derived Fractional Flow Reserve
    Tsuyoshi Ohsue, Shinke Toshiro, Otake Hiromasa, Yu Kuroda, Hiroto Kinutani, Akihide Konishi, Ryo Nishio, Noritoshi Hiranuma, Masamichi Iwasaki, Yu Taniguchi, Hirotoshi Hariki, Takumi Inoue, Masayuki Nakagawa, Junya Shite, Hirata Ken-ichi
    European Society of Cardiology meeting 2012, Sep. 2012, English, European Society of Cardiology, ミュンヘン, International conference
    Poster presentation

  • Paraoxonase-1 (PON1) activity is associated with clopidogrel response and intra-stent thrombus after drug-eluting stent implantation in the CYP2C19 loss-of-function polymorphism carriers
    Ryo Nishio, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Masamichi Iwasaki, Akihide Konishi, Junya Shite, Hirata Ken-ichi
    European Society of Cardiology meeting 2012, Sep. 2012, English, European Society of Cardiology, ミュンヘン, International conference
    Poster presentation

  • Impact of Cytochrome P450 2C19 Loss-of-function Polymorphism on Intra-stent Thrombus after Sirolimus- and Everolimus-eluting Stent Implantation Assessed by Angioscopy and Optical Coherence Tomography
    Masamichi Iwasaki, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Masaru Kuroda, Junya Shite
    European Society of Cardiology meeting 2012, Sep. 2012, English, European Society of Cardiology, ミュンヘン, International conference
    Poster presentation

  • Long-term follow-up of sirolimus-eluting stent implanted in coronary bifurcation lesion: Insight from optical coherence tomography
    Hirotoshi Hariki, Junya Shite, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Hirata Ken-ichi
    第21回日本心血管インターベンション治療学会, Jul. 2012, English, 日本心血管インターベンション治療学会, 新潟, Domestic conference
    Poster presentation

  • Impact of eicosapentanoic acid and statin therapy on coronary thin-cap fibroatheroma: Assessment by optical coherence tomography
    Ryo Nishio, Junya Shite, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Hirata Ken-ichi
    第21回日本心血管インターベンション治療学会, Jul. 2012, English, 日本心血管インターベンション治療学会, 新潟, Domestic conference
    Oral presentation

  • Gradually developed giant right coronary artery aneurysm; a case report
    Masamichi Iwasaki, Junya Shite, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hirotoshi Hariki, Akihide Konishi, Hiroto Kinutani, Hirata Ken-ichi
    第21回日本心血管インターベンション治療学会, Jul. 2012, English, 日本心血管インターベンション治療学会, 新潟, Domestic conference
    Poster presentation

  • Controversy of final kissing inflation after single stenting to bifurcation lesion: optical coherence tomography assessment for technique and stent technology
    Hirotoshi Hariki, Junya Shite, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Hirata Ken-ichi
    第21回日本心血管インターベンション治療学会, Jul. 2012, English, 日本心血管インターベンション治療学会, 新潟, Domestic conference
    Poster presentation

  • Comparisons of temporal changes in peri-stent coronary plaque components between lesions treated with bare-metal and 1st generation drug-eluting stents
    Masayuki Nakagawa, Shinke Toshiro, Otake Hiromasa, Ryoji Nagoshi, Amane Kozuki, Ryo Nishio, Masamichi Iwasaki, Akihide Konishi, Junya Shite, Hirata Ken-ichi
    第21回日本心血管インターベンション治療学会, Jul. 2012, English, 日本心血管インターベンション治療学会, 新潟, Domestic conference
    Poster presentation

  • Clinical usefulness of Non-Invasive Cardiac System (NICaS) for measuring whole body bioimpedance to evaluate cardiac output in pulmonary hypertension patients
    Yu Taniguchi, Noriaki Emoto, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Hirotoshi Hariki, Tsuyoshi Osue, Takumi Inoue, Masamichi Iwasaki, Ryo Nishio, Hiroto Kinutani, Akihide Konishi, Noritoshi Hiranuma, Masaru Kuroda, Junya Shite, Hirata Ken-ichi
    第21回日本心血管インターベンション治療学会, Jul. 2012, English, 日本心血管インターベンション治療学会, 新潟, Domestic conference
    Poster presentation

  • Bosentan, Sildenafil therapy and ASD closure with Amplatzer Septal Occluder in a patient with severe pulmonary hypertension
    Yu Taniguchi, Noriaki Emoto, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Hirotoshi Hariki, Tsuyoshi Osue, Takumi Inoue, Masamichi Iwasaki, Ryo Nishio, Hiroto Kinutani, Akihide Konishi, Noritoshi Hiranuma, Masaru Kuroda, Junya Shite, Hirata Ken-ichi
    第21回日本心血管インターベンション治療学会, Jul. 2012, English, 日本心血管インターベンション治療学会, 新潟, Domestic conference
    Poster presentation

  • A case with recurrent peri-stent contrast staining after recanalization of sirolimus-eluting stent occlusion
    Amane Kozuki, Junya Shite, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryouji Nagoshi, Takumi Inoue, Hirotoshi Hariki, Tuyoshi Osue, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Hirata Ken-ichi
    第21回日本心血管インターベンション治療学会, Jul. 2012, English, 日本心血管インターベンション治療学会, 新潟, Domestic conference
    Oral presentation

  • Uniform Vessel Healing after Everolimus-eluting Stent implantation: Detailed Comparison with Paclitaxel-eluting Stent by Optical Coherence Tomography
    Tsuyoshi Ohsue, Junya Shite, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Hiroto Kinutani, Akihide Konishi, Hirata Ken-ichi
    第76回 日本循環器学会学術集会, Mar. 2012, English, 第76回 日本循環器学会学術集会, 福岡, Domestic conference
    Public symposium

  • The Relationship between Culprit Plaque Characters and the Microvascular Resistance: Detaled Assessment by iMAPTM and Pressure Measurement
    Tsuyoshi Ohsue, Junya Shite, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Hiroto Kinutani, Akihide Konishi, Hirata Ken-ichi
    第76回 日本循環器学会学術集会, Mar. 2012, English, 第76回 日本循環器学会学術集会, 福岡, Domestic conference
    Oral presentation

  • The Impact Of Paraoxonase 1 Activity On The Incidence Of Intra Stent Thrombus After Drug Eluting Stent Implantation In The 日本語 Cyp2c19 Loss Of Function Polymorphism Carriers
    Ryo Nishio, Shinke Toshiro, Otake Hiromasa, Yoko Haraguchi, Junya Shite, Hirata Ken-ichi, Ishida Tatsuro, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Junya Shite
    ACC12 i2, Mar. 2012, English, ACC12 i2, シカゴ, アメリカ, International conference
    Oral presentation

  • The Impact Of Mid-term Oct Findings On Long-term Clinical Events After Drug-eluting Stents Implantation
    Otake Hiromasa, Shinke Toshiro, Junya Shite, Hirata Ken-ichi
    ACC12 i2, Mar. 2012, English, ACC12 i2, シカゴ, アメリカ, International conference
    Oral presentation

  • Serial Oct And Histopathology Analysis Following 1st And New Generation Drug Eluting Stents Implantation In Swine Coronary Artery
    Hiranuma Noritoshi, Shinke Toshiro, Gaku Nakazawa, Otake Hiromasa, Matsumoto Daisuke, Takeshi Ijichi, Ohsue Tsuyoshi, Junya Shite, Hirata Ken-ichi
    ACC12 i2, Mar. 2012, English, ACC12 i2, シカゴ, アメリカ, International conference
    Oral presentation

  • Relationship between Optical Coherence Tomography (OCT), Intravascular Ultrasound Tomography (IVUS) and Pressure-Derived Fractional Flow Reserve
    Tsuyoshi Ohsue, Junya Shite, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Hiroto Kinutani, Akihide Konishi, Hirata Ken-ichi
    第76回 日本循環器学会学術集会, Mar. 2012, English, 第76回 日本循環器学会学術集会, 福岡, Domestic conference
    Oral presentation

  • Optical Coherence Tomography Assessment of Histopathology after 1st and 2nd Generation Drug-Eluting Stent Implant in Pig Coronary Model
    Hiranuma Noritoshi, Shinke Toshiro, Gaku Nakazawa, Otake Hiromasa, Daisuke Matsumoto, Takeshi Ijichi, Tsuyoshi Osue, Junya Shite, Hirata Ken-ichi
    ACC12 i2, Mar. 2012, English, ACC12 i2, シカゴ, アメリカ, International conference
    Oral presentation

  • OCT Assessment of In-stent Restenosis and Its Impact on the Treatment Outcome
    Ryoji Nagoshi, Junya Shite, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Ohsue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Hirata Ken-ichi
    第76回 日本循環器学会学術集会, Mar. 2012, English, 第76回 日本循環器学会学術集会, 福岡, Domestic conference
    Oral presentation

  • Neointimal Coverage of Jailed Strut Following Single Stenting to Bifurcation: Optical Coherence Tomography Assessment for 3 Types of Drug-eluting stents
    Hirotoshi Hariki, Shinke Toshiro, Otake Hiromasa, Junya Shite, Hirata Ken-ichi
    ACC12 i2, Mar. 2012, English, ACC12 i2, シカゴ, アメリカ, International conference
    Oral presentation

  • In-vivo Assessment of Neoatherosclerosis after Sirolimus-eluting Stent implantation: Comparisons of Serial Optical Coherence Tomography Findings between Early and Late Follow-up
    Amane Kozuki, Junya Shite, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Ohsue, Yu Taniguchi, Masamichi Iwasaki, Noritoshi Hiranuma, Ryo Nishio, Hiroto Kinutani, Akihide Konishi, Hirata Ken-ichi
    第76回 日本循環器学会学術集会, Mar. 2012, English, 第76回 日本循環器学会学術集会, 福岡, Domestic conference
    Oral presentation

  • Investigation of vascular response between patients with or without diabetes mellitus after everolimus-eluting stent implantation; optical coherence tomography study
    Masamichi Iwasaki, Otake Hiromasa, Shinke Toshiro, Junya Shite, Hirata Ken-ichi
    ACC12, Mar. 2012, English, ACC12, シカゴ, アメリカ, International conference
    Oral presentation

  • Impact of Mid-term OCT Findings on Long-term Clinical Events after Drug-eluting Stents Implantation
    Otake Hiromasa, Junya Shite, Shinke Toshiro, Amane Kohzuki, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Ohsue, Yu Taniguchi, Ryoji Nagoshi, Noritoshi Hiranuma, Masayuki Nakagawa, Ryo Nishio, Hiroto Kinutani, Masamichi Iwasaki, Akihide Konishi, Hirata Ken-ichi
    第76回 日本循環器学会学術集会, Mar. 2012, English, 第76回 日本循環器学会学術集会, 福岡, Domestic conference
    Oral presentation

  • Impact Of Hemodialysis On Vessel Healing After Drug-eluting Stent Implantation
    Akihide Konishi, JUNYA Shite, Shinke Toshiro, Daisaku Nakatani, Otake Hiromasa, Hirata Ken-ichi
    ACC12 i2, Mar. 2012, English, ACC12 i2, シカゴ, アメリカ, International conference
    Oral presentation

  • Impact of Hemodialysis on Vessel Healing after Drug-eluting Stent Implantation
    Akihide Konishi, Junya Shite, Shinke Toshiro, Daisaku Nakatani, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Tsuyoshi Ohsue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Hiroto Kinutani, Noritoshi Hiranuma, Hirata Ken-ichi
    第76回 日本循環器学会学術集会, Mar. 2012, English, 第76回 日本循環器学会学術集会, 福岡, Domestic conference
    Oral presentation

  • Impact of Genotype of Clopidgrel Resistance on Lesion Outcome after Drug-eluting Stent Implantation in 日本語: An Optical Coherence Tomography Analysis
    Shinke Toshiro, Junya Shite, Ryo Nishio, Otake Hiromasa, Takahiro Sawada, Amane Kohzuki, Hirotoshi Hariki, Takumi Inoue, Akihide Konishi, Hirata Ken-ichi
    第76回 日本循環器学会学術集会, Mar. 2012, English, 第76回 日本循環器学会学術集会, 福岡, Domestic conference
    Public symposium

  • Detailed Investigation of Vascular Response between Patients with or without Diabetes Mellitus after Everolimus-eluting Stent Implantation; Optical Coherence Tomography Study
    Masamichi Iwasaki, Junya Shite, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Hirotoshi Hariki, Amane Kozuki, Tsuyoshi Ohsue, Takumi Inoue, Yu Taniguchi, Ryo Nishio, Hiroto Kinutani, Akihide Konishi, Noritoshi Hiranuma, Hirata Ken-ichi
    第76回 日本循環器学会学術集会, Mar. 2012, English, 第76回 日本循環器学会学術集会, 福岡, Domestic conference
    Oral presentation

  • Assessment of Neoatherosclerosis after Sirolimus-eluting Stents Using Angioscopy and Optical Coherence Tomography
    Takumi Inoue, Junya Shite, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Tsuyoshi Ohsue, Masamichi Iwasaki, Ryo Nishio, Yu Taniguchi, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Hirata Ken-ichi
    第76回 日本循環器学会学術集会, Mar. 2012, English, 第76回 日本循環器学会学術集会, 福岡, Domestic conference
    Oral presentation

  • 心房中隔欠損症に対するAmplatzer Septal Occluderによる閉鎖術を施行した13症例の検討
    名越良治, 志手淳也, Shinke Toshiro, Otake Hiromasa, 谷口 悠, Hirata Ken-ichi
    第18回日本心血管インターベンション治療学会 近畿地方会, Feb. 2012, Japanese, 第18回日本心血管インターベンション治療学会 近畿地方会, 大阪, Domestic conference
    Oral presentation

  • Uniform Vessel Healing after Everolimus-eluting Stent Implantation:
    Tsuyoshi Osue, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue
    TCT2011, Nov. 2011, English, TCT2011, シカゴ, アメリカ, International conference
    Oral presentation

  • Long-term follow-up of sirolimus-eluting stent implanted in coronary bifurcation lesion:
    Hirotoshi Hariki, Shinke Toshiro, Otake Hiromasa, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Takeshi Osue
    TCT2011, Nov. 2011, English, TCT2011, シカゴ, アメリカ, International conference
    Oral presentation

  • In-vivo Assessment of Neoatherosclerosis after Sirolimus-eluting Stent Implantation: Comparisons of
    Amane Kozuki, Shinke Toshiro, Otake Hiromasa, Naoki Miyoshi, Masayuki Nakagawa, Ryoji Nagoshi, Hirotoshi Hariki, Takumi Inoue
    TCT2011, Nov. 2011, English, TCT2011, シカゴ, アメリカ, International conference
    Oral presentation

  • Impact of Stent Platform of Paclitaxel-eluting Stents: Detailed Assessment of Neointimal Distribution by Optical Coherence Tomography
    Otake Hiromasa, Shinke Toshiro, Naoki Miyoshi, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki
    ・TCT 2011, Nov. 2011, English, TCT 2011, シカゴ, アメリカ, International conference
    Oral presentation

  • Elevated Pre-procedural High-sensitive CRP Levels are Associated with Uneven Vessel Healing after Paclitaxel-eluting Stents Implantation in Patients with Stable Angina
    Otake Hiromasa, Shinke Toshiro, Naoki Miyoshi, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki
    TCT2011, Nov. 2011, English, TCT2011, シカゴ, アメリカ, International conference
    Oral presentation

  • 非薬剤溶出性ステント留置にて消失した冠動脈龍瘤を血管内超音波と光干渉断層映像法で観察し得た一例
    絹谷洋人, 志手淳也, Shinke Toshiro, Otake Hiromasa, 中川雅之, 名越良治, 井上琢海, 大末剛史, 上月周, 張木洋寿, 岩崎正道, 谷口 悠, 小西明英, 西尾 亮, 平沼永敏, Hirata Ken-ichi
    第17回日本心血管インターベンション治療学会近畿地方会, Oct. 2011, Japanese, 第17回日本心血管インターベンション治療学会近畿地方会, 大阪, Domestic conference
    Oral presentation

  • OCTガイド下に、LMT bifurcationにPCIを施行した一例
    谷口 悠, Shinke Toshiro, 絹谷洋人, 小西明英, 平沼永敏, 西尾 亮, 岩崎正道, 大末剛史, 張木洋寿, 井上琢海, 上月周, 名越良治, 中川雅之, Otake Hiromasa, 志手淳也, Hirata Ken-ichi
    第17回日本心血管インターベンション治療学会近畿地方会, Oct. 2011, Japanese, 第17回日本心血管インターベンション治療学会近畿地方会, 大阪, Domestic conference
    Oral presentation

  • トルバプタンが心不全の改善に有効であったミオパチーに伴う拡張型心筋症の1例
    濱田 佳奈, 粟野 宏之, Ri Tomoko, Nakagawa Taku, 八木 麻理子, 張木 洋寿, 名越 良治, Otake Hiromasa, Hirata Ken-ichi, Takeshima Yasuhiro
    第254回日本小児科学会兵庫県地方会, Sep. 2011, Japanese, 日本小児科学会兵庫県地方会, 姫路, Domestic conference
    Others

  • OCT-based approaches for the evaluation of DES: now and the future
    Otake Hiromasa, Junya Shite, Shinke Toshiro, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Takeshi Osue, Yuu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hirata Ken-ichi
    第59回日本心臓病学会学術集会, Sep. 2011, English, 第59回日本心臓病学会学術集会, 神戸, Domestic conference
    Public symposium

  • The comparison between frequency domain optical coherence tomography and intravascular ultrasound after stent implantation
    Tsuyoshi Osue, Junya Shite, Shinke Toshiro, Otake Hiromasa, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagosh, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Yuu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hirata Ken-ichi
    第20回日本心血管インターベンション治療学会, Jul. 2011, English, 日本心血管インターベンション治療学会, 大阪, Domestic conference
    Oral presentation

  • Natural consequence of stent malapposition tissue prolapse and thrombus assessed by optical coherence tomography
    Hiroyuki Kawamori, Junya Shite, Shinke Toshiro, Otake Hiromasa, Daisuke Matsumoto, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Harik, Takumi Inoue, Tsuyoshi Osue, Yuu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hirata Ken-ichi
    第20回日本心血管インターベンション治療学会, Jul. 2011, English, 日本心血管インターベンション治療学会, 大阪, Domestic conference
    Poster presentation

  • Detailed assessment of plaque components susceptible to slow flow phenomenon: insights from iMAP analysis
    Masayuki Nakagawa, Junya Shite, Shinke Toshiro, Otake Hiromasa, Daisuke Matsumoto, Hiroyuki Kawamori, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yuu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hirata Ken-ichi
    第20回日本心血管インターベンション治療学会, Jul. 2011, English, 日本心血管インターベンション治療学会, 大阪, Domestic conference
    Oral presentation

  • Assessment of debulking effect of rotational atherectomy using frequency domain type optical coherence tomography (C7-OCT)
    Noritoshi Hiranuma, Junya Shite, Shinke Toshiro, Otake Hiromasa, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yuu Taniguchi, Ryo Nishio, Hirata Ken-ichi
    第20回日本心血管インターベンション治療学会, Jul. 2011, English, 日本心血管インターベンション治療学会, 大阪, Domestic conference
    Oral presentation

  • A novel radiofrequency signal analysis for coconary plaque characterization at culprit lesion using iMAP
    Amane Kozuki, Junya Shite, Shinke Toshiro, Otake Hiromasa, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yuu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hirata Ken-ichi
    第20回日本心血管インターベンション治療学会, Jul. 2011, English, 日本心血管インターベンション治療学会, 大阪, Domestic conference
    Oral presentation

  • A case with spontaneous coronary dissection which entry point was detected by frequency domain OCT.
    Masayuki Nakagawa, Junya Shite, Shinke Toshiro, Otake Hiromasa, Daisuke Matsumoto, Hiroyuki Kawamori, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yuu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hirata Ken-ichi, Hitoshi Minami, Okada Kenji, Okita Yutaka
    第20回日本心血管インターベンション治療学会, Jul. 2011, English, 日本心血管インターベンション治療学会, 大阪, Domestic conference
    Oral presentation

  • A case of nine months follow-up optical coherence tomography examination for thin cap fibroatheroma with lipid-lowering therapy
    Ryo Nishio, Junya Shite, Shinke Toshiro, Otake Hiromasa, DAisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Noritoshi Hiranuma, Hirata Ken-ichi
    第20回日本心血管インターベンション治療学会, Jul. 2011, English, 日本心血管インターベンション治療学会, 大阪, Domestic conference
    Oral presentation

  • Potential Benefit of Final Kissing Inflation after Single Stenting to Bifurcation Lesions: Difference of Optical Coherence Tomography Findings in Sirolimus and Paclitaxel-Eluting Stents
    Hirotoshi Hariki, Junya Shite, Shinke Toshiro, Otake Hiromasa, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Tsuyoshi Ohsue, Yu Taniguchi, Nishio Ryo, Noritoshi Hiranuma, Hirata Ken-ichi
    60Th American College of Cardiology, Apr. 2011, English, American College of Cardiology, New Orleans, アメリカ, International conference
    Poster presentation

  • Natural Consequence of Stent Malaposition Assessed by Optical Coherence Tomography
    Hiroyuki Kawamori, Junya Shite, Shinke Toshiro, Otake Hiromasa, Daisuke Matumoto, Masayuki Nakagawa, Yoshiharu Nagoshi, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Ohsue, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hirata Ken-ichi
    60Th American College of Cardiology, Apr. 2011, English, American College of Cardiology, New Orleans, アメリカ, International conference
    Poster presentation

  • Influence of Proton Pump Inhibitors (PPIs) on the Formation of Intra-Stent Thrombus in Japanese Patients Receiving Clopidogrel with or without Cytochrome P450 2c19*2 Polymorphism
    Ryo Nishio, Shinke Toshiro, Junya Shite, Takahiro Sawada, Toh Ryuji, Yoko Haraguchi, Otake Hiromasa, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Yu Taniguchi, Noritoshi Hiranuma, Hirata Ken-ichi
    60Th American College of Cardiology, Apr. 2011, English, American College of Cardiology, New Orleans, アメリカ, International conference
    Poster presentation

  • Impact Of Cytochrome P450 2c19*2 Polymorphism On The Target Lesion Outcome After Drug-eluting Stent Implantation In Japanese Patients Receiving Clopidogrel.
    Ryo Nisho, Shinke Toshiro, Junya Shite, Takahiro Sawada, Toh Ryuji, Yoko Haraguchi, Otake Hiromasa, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Yu Taniguchi, Noritoshi Hiranuma, Hirata Ken-ichi
    60Th American College of Cardiology, Apr. 2011, English, American College of Cardiology, New Orleans, アメリカ, International conference
    Poster presentation

  • Assessment of Yellow Neointima and Mural Thrombi after 1st Generation Sirolimus-Eluting Stents Using Angioscope and Optical Coherence Tomography
    Takumi Inoue, Shinke Toshiro, Junya Shite, Otake Hiromasa, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Tsuyoshi Ohsue, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hirata Ken-ichi
    60Th American College of Cardiology, Apr. 2011, English, American College of Cardiology, New Orleans, アメリカ, International conference
    Poster presentation

  • A Novel Radiofrequency Signal Analysis for Coronary Plaque Characterization at Culprit Lesion Using ImapTM: How Can We Use the New Parameter: Confidence Level?
    Amane kozuki, Junya Shite, Shinke Toshiro, Otake Hiromasa, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Hirotoshi Hiranuma, Ryo Nishio, Hirata Ken-ichi
    60Th American College of Cardiology, Apr. 2011, English, American College of Cardiology, New Orleans, アメリカ, International conference
    Poster presentation

  • Vulnerable plaque evaluation by intravascular ultrasound and optical coherence tomography
    Junya Shite, Shinke Toshiro, Otake Hiromasa, Daisuke Matsumoto, Hiroyuki Kawamori, Amane Kozuki, Masayuki Nakagawa, Ryoji Nagoshi, Takumi Inoue, Hirotoshi Hariki, Takeshi Osue, Yuu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Takahiro Sawada, Hirata Ken-ichi
    第75回日本循環器学会総会・学術集会, Mar. 2011, English, 日本循環器学会, 横浜, Domestic conference
    Public symposium

  • DES留置後再狭窄を繰り返したクロピドグレル抵抗性の一例
    西尾亮, 志手淳也, Shinke Toshiro, Otake Hiromasa, 松本大典, 川森裕之, 中川雅之, 名越良治, 井上琢海, 大末剛史, 上月周, 張木洋寿, 谷口悠, 平沼永敏
    第16回日本心血管インターベンション治療学会, Feb. 2011, Japanese, 日本心血管インターベンション治療学会, 大阪, Domestic conference
    Oral presentation

  • Factor analysis of neointimal coverage after sirolimus-eluting stents implantation in patients with stable coronary artery disease
    Amane Kozuki, Junya Shite, Shinke Toshiro, Otake Hiromasa, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryouji Nagoshi, Takumi Inoue, Hirotoshi Hariki, Tuyoshi Osue, Yu Taniguchi, Ryo Nishio, Nagatoshi Hiranuma, Hirata Ken-ichi
    European Society of Cardiology 2010, Sep. 2010, English, European Society of Cardiology, ストックホルム, スウェーデン, International conference
    Poster presentation

  • Assessment of yellow neointima and mural thrombi after 1st generation sirolimus-eluting stents using angioscope and optical coherence tomography
    Takumi Inoue, Shinke Toshiro, Junya Shite, Otake Hiromasa, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki Hirotoshi Hariki, Tsuyoshi Ohsue, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Hirata Ken-ichi
    Transcatheter Cardiovascular Therapeutics TCT2010, Sep. 2010, English, Transcatheter Cardiovascular Therapeutics TCT, ワシントン, アメリカ, International conference
    Poster presentation

  • Evaluation of taxus liberte stent by using optical coherence tomography in comparison with taxus express stent
    Shite Junya, Shinke Toshiro, Otake Hiromasa, Hirata Kenichi
    第74回日本循環器学会総会, Mar. 2010, Japanese, 日本循環器学会, 京都, Domestic conference
    Poster presentation

  • Reliability of non-invasive cardiac output measurement (NICaSTM) in outpatients monitoring
    Shite Junya, Shinke Toshiro, Otake Hiromasa, Yokoyama Mitsuhiro
    第72回日本循環器学会総会・学術総会, Mar. 2008, Japanese, 日本循環器学会, 福岡, Domestic conference
    Poster presentation

  • Delayed Neointimalization on Sirolimus-eluting Stents Located at a Major Side Branch Orfice – Evaluation by Optical Coherence Tomography
    Shite Junya, Shinke Toshiro, Otake Hiromasa, Hirata Kenichi
    第72回日本循環器学会, Mar. 2008, Japanese, 日本循環器学会, 福岡, Domestic conference
    Poster presentation

  • Clinical Features of Plaque Progression in patients with Stable Angina: Binary Intravascular Ultrasound Virtual Histology Study.
    Shite Junya, Shinke Toshiro, Otake Hiromasa, Hirata Kenichi
    第72回日本循環器学会, Mar. 2008, Japanese, 日本循環器学会, 福岡, Domestic conference
    Oral presentation

  • Can virtual histology intravascular ultrasound in vivo?
    Shite Junya, Shinke Toshiro, Otake Hiromasa, Hirata Kenichi
    第72回日本循環器学会, Mar. 2008, Japanese, 日本循環器学会, 福岡, Domestic conference
    Oral presentation

  • 非侵襲的心拍出量測定システム（NICaS)を用いた外来慢性心不全患者の評価～運動耐容能、血漿BNP濃度との比較～
    Shite Junya, Shinke Toshiro, Otake Hiromasa, Hirata Kenichi
    第55回日本心臓病学会学術集会, Sep. 2007, Japanese, 日本心臓病学会, 東京, Domestic conference
    Poster presentation

  • 冠動脈プラークが退縮する症例における血中アディポネクチン値および冠動脈プラーク性状の変化：Virtual Histology IVUSによる検討
    Shite Junya, Shinke Toshiro, Otake Hiromasa, Hirata Kenichi, Yokoyama Mitsuhiro
    第55回日本心臓病学会学術集会, Sep. 2007, Japanese, 日本心臓病学会, 東京, Domestic conference
    Oral presentation

  • Thin-cap fibroatheroma progressionの一連の変化をVH-IVUSとOCTにて観察しえた一例
    Shite Junya, Shinke Toshiro, Otake Hiromasa, Hirata Kenichi, Yokoyama Mitsuhiro
    第55回日本心臓病学会学術集会, Sep. 2007, Japanese, 日本心臓病学会, 東京, Domestic conference
    Oral presentation

  • Evoluationof delayed tissue coverage on sirolimus ?eluting stents from six ?months to twelve-month-optical coherence tomography study
    Shite Junya, Shinke Toshiro, Otake Hiromasa, Yokoyama Mitsuhiro
    EuropeanSocietyofCardiovascular, Sep. 2007, English, European Society of Cardiovascular, ウィーン, Austria, International conference
    Poster presentation

  • Effect of pioglitazone on coronary plaque volume and components in patients with type 2 diabetes: intravascular ultrasound virtual histology study
    Shite Junya, Shinke Toshiro, Otake Hiromasa, Hirata Kenichi, Yokoyama Mitsuhiro
    ヨーロッパ心臓病学会ＥＳＣ2007, Sep. 2007, English, ヨーロッパ心臓病学会, Vienna, オーストリア, International conference
    Oral presentation

  • Cypher stent留置2年以上後にvery late thrombosis をきたした症例を発症前後に光干渉断層法（OCT）にて観察しえた一例
    Shite Junya, Shinke Toshiro, Otake Hiromasa, Hirata Kenichi, Yokoyama Mitsuhiro
    第55回日本心臓病学会学術集会, Sep. 2007, Japanese, 日本心臓病学会, 東京, Domestic conference
    Oral presentation

  • Coronary plaque regression is closely related to the decrease of necrotic core with increase of plasma adiponectin level: 6-month binary studies with virtual histology intravascular ultrasound
    Shite Junya, Shinke Toshiro, Otake Hiromasa, Hirata Kenichi, Yokoyama Mitsuhiro
    ヨーロッパ心臓病学会ＥＳＣ2007, Sep. 2007, English, ヨーロッパ心臓病学会, Vienna, オーストリア, International conference
    Poster presentation

  • persistent improvement of cardiac function was observed by impedance cardiography in patients erwent PCI
    Shite Junya, Shinke Toshiro, Otake Hiromasa, Hirata Kenichi
    第17回日本心血管インターベンション学会学術集会, Jun. 2007, English, 日本心血管インターベンション学会, 福島県, Domestic conference
    Poster presentation

■ Research Themes
  • Clarifying the mechanisms of atherosclerotic cardiovascular diseases via genome and single cell integrated omics analyses.
    平田 健一, 井上 大志, 大竹 寛雅, 山中 勝弘, 江本 拓央, 岡田 健次, 山下 智也
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2023 - 31 Mar. 2026
    本研究の目的は、動脈硬化性疾患（冠動脈疾患CAD、大動脈瘤AA、大動脈弁狭窄症AS）のシングルセルアトラスの作成と全ゲノム解析を行い、トランスオミックス統合解析を行うことで、それぞれの疾患の相違点を炙り出し、疾患のリスク層別化を行い、発症メカニズムを解明することである。本研究では、これら3疾患について、1）病変部のシングルセル＋核RNAシークエンス（scRNAseq+snRNAseq）からシングルセルアトラスを作成、各々の疾患特異的マクロファージの同定を行うと同時に、2）T細胞レパトア解析から各々の疾患において、特徴的な抗原が存在するのかを明らかにする。さらには、3）Genotyping of Transcriptomes (GoT)による シングルセルレベルで骨髄のクローン性造血の関与を調べる解析と4）全ゲノム解析による遺伝素因とトランスクリプトームの関連を解析する、expression quantitative locus (eQTL)解析を行う。3)と4)の実施にて、ゲノム・トランスクリプトーム統合解析が達成できる。すでに、3疾患の少数サンプルでのシングルセルトランスクリプトーム解析は終了し、シングルセルアトラスの概要は見えてきている。CADでT細胞受容体レパトア解析が終了し論文報告を行った。AAでは、結果を受けマウスでの実験も同時実施しており、マクロファージやB細胞での疾患特異的な特徴のデータを得ている。ASでのクローン性造血(CH)の原因となる体細胞遺伝子変異の解析数を増加させており、少数患者でのGoT解析を進めている。まずは3)GoTの統合解析手法の確立を目指す。全ゲノム解析は実施できておらず、4)eQTLの実施までには、さらに時間が必要と考えられる。

  • 冠動脈プラーク内部に発生する応力評価を用いた高リスクプラーク同定の試み
    大竹 寛雅
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2021 - 31 Mar. 2024
    我々は数値流体力学解析(Computational Fluid Dynamic: CFD）を用いてプラーク外だけではなくプラーク内部から発生する機械的ストレス(plaque structural stress: PSS)を定量化する新たな手法を確立し、プラークの不安定化や破綻との関連を検討することを目的に本検討課題に取り組んでいる。これまで申請者らは、光干渉断層影像法(Optical coherence tomography: OCT)画像からCFDを用いて算出した様々な血行力学的因子が、プラークの破綻部位や破綻様式と関連することを報告してきた。しかしOCTのみで作成した3D血管モデルでは血管の屈曲やねじれを反映できず、PSSの評価は困難であった。また剪断力やWall shear stressを検討する際にも、OCTだけを用いた血管を直線化したこれまでのモデルでは、正確な評価が難しく、ひいては信頼度の高い心血管イベント予測は困難であることが予想された。そこで本検討課題では、まず最初のステップとして2方向の血管造影により構築した3D血管モデルにOCT画像を融合させる方法を確立すべく検討を開始した。現在まで、5例の血管造影、OCTを施行された患者のデータを用いて、2方向の血管造影により構築した3D血管モデルにOCT画像を融合させる方法に関する検討を行い、スムーズな解析の進行と、その方法論を確立するに至っている。その過程で愛媛大学理工学科機械工学講座:保田和則教授や愛媛大学医学部附属病院、清家史靖医師と、定期的にweb会議を施行、助言を頂きながら順調な計画の進行を認めている。今後はADINA 8.6.1 (ADINA R&D, Inc., USA)を用いてプラークにかかる剪断力やWSS, PSSを解析する方法を確立するべく実際の症例を追加し検討を行う予定である。

  • 木内 邦彦, 福沢 公二, 大竹 寛雅, 佐々木 直人
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2018 - 31 Mar. 2021
    2018年度にはLGEMRIを用いて同定した心房繊維化領域への高周波通電の効果について、良好な反応（心房細動停止ないし他の心房性不整脈への移行）を認める場合の特徴を明らかにすることができました。①一定の信号強度を有する（＞2SD)に加えて、②まだらな分布をしている（entropyが高い）ことが必須条件となります。低電位領域は心房細動器質として注目されておりましたが、LGEMRIで同定された領域はさらに特異度が高くより効率的な心房細動アブレーションが可能となる事を確認できました。 2019年度は、同手法を用いて個々の心房細動基質に直接的に治療を行う、いわゆるテーラーメイド治療を確立し前向きに治療介入を行いました。最終アブレーション１年後の長期成績についても通常アブレーション法（肺静脈隔離術）に比して良好な成績を得ることを確認できました。本成果は2020年3月に開催予定であった第84回日本循環器学会学術集会で発表予定でした。またLGEMRIを用いた治療創の評価についても研究を行い、原著論文として受理されております。（J Cardiovasc Electrophysiol. 2019 Oct;30(10):1830-1840）また炎症分布の視覚化については、前向き介入研究を行い、PETMRIの撮像プロトコールの確立を目指しております。現時点では、治療により形成された強い心房炎症についてはPETMRIで視覚化できることが確認できました。同研究成果については近日中に論文投稿を予定しております。また初年度のプロトコール論文（Circ Rep 2019; 1: 149 - 152 doi: 10.1253/circrep.CR-19-0003）に基づきPETMRIを用いて心房炎症の視覚化の確立を行っております。治療創に認める強力な心房炎症はPETMRIによる視覚化に成功しており、本成果は論文として投稿準備をしております。
    Competitive research funding

  • Otake Hiromasa
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2015 - 31 Mar. 2018, Principal investigator
    We showed that unstable, rupture prone plaque is related with several hemodynamic parameters such as wall shear stress and axial plaque stress. Also, we showed that, in patients treated with coronary stents, vessel healing is affected not only by wall shear stress, but by wall shear stress exposed time and wall shear stress variability. These findings suggest that using computational fluid dynamics analysis might help patients with coronary artery disease to prevent acute coronary event as well as stent related events such as restenosis and stent thrombosis.
    Competitive research funding

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