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OOE KeisukeUniversity Hospital / Orthopedic SurgeryAssistant Professor
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■ Award- Jun. 2024 第50回日本骨折治療学会学術集会, 学会賞, 骨折関連感染症治療の有効性に 持続局所抗菌薬潅流（CLAP）が及ぼす影響 ー多施設研究ー
- Jun. 2023 第46回日本骨・関節感染症学会, 最優秀演題賞, 高濃度抗菌薬が骨髄由来細胞の増殖能および分化能に与える影響
- Jun. 2019 第45回日本骨折治療学会学術集会, 学会賞, 解剖用屍体におけるiMAPから髄内に投与された抗菌薬の薬物動態の検討
- Nov. 2018 第16回 ORS ISFR Biennial Workshop, Best case report award
- Nov. 2018 第16回 ORS ISFR Biennial Workshop, Best presentation award
- Mar. 2008 the 37th Conference of the Japanese Society of Oral Implantology, Best Poster Award
- BACKGROUND: Low-intensity pulsed ultrasound (LIPUS) is a non-invasive therapy that accelerates fracture healing. As a new treatment method for fracture, we recently reported that the transcutaneous application of CO2 accelerated fracture healing in association with promoting angiogenesis, blood flow, and endochondral ossification. We hypothesized that transcutaneous CO2 application, combined with LIPUS, would promote bone fracture healing more than the single treatment with either of them. METHODS: Femoral shaft fractures were produced in 12-week-old rats. Animals were randomly divided into four groups: the combination of CO2 and LIPUS, CO2, LIPUS, and control groups. As the transcutaneous CO2 application, the limb was sealed in a CO2-filled bag after applying hydrogel that promotes CO2 absorption. Transcutaneous CO2 application and LIPUS irradiation were performed for 20 min/day, 5 days/week. At weeks 1, 2, 3, and 4 after the fractures, we assessed the fracture healing process using radiography, histology, immunohistochemistry, real-time PCR, and biomechanical assessment. RESULTS: The fracture healing score using radiographs in the combination group was significantly higher than that in the control group at all time points and those in both the LIPUS and CO2 groups at weeks 1, 2, and 4. The degree of bone fracture healing in the histological assessment was significantly higher in the combination group than that in the control group at weeks 2, 3, and 4. In the immunohistochemical assessment, the vascular densities of CD31- and endomucin-positive microvessels in the combination group were significantly higher than those in the control and LIPUS groups at week 2. In the gene expression assessment, significant upregulation of runt-related transcription factor 2 (Runx2) and vascular endothelial growth factor (VEGF) was detected in the combination group compared to the LIPUS and CO2 monotherapy groups. In the biomechanical assessment, the ultimate stress was significantly higher in the combination group than in the LIPUS and CO2 groups. CONCLUSION: The combination therapy of transcutaneous CO2 application and LIPUS had a superior effect in promoting fracture healing through the promotion of angiogenesis and osteoblast differentiation compared to monotherapy.Oct. 2024, BMC musculoskeletal disorders, 25(1) (1), 863 - 863, English, International magazineScientific journal
- 金原出版(株), Apr. 2024, 整形・災害外科, 67(5) (5), 681 - 687, Japanese
- AIMS: Continuous local antibiotic perfusion (CLAP) has recently attracted attention as a new drug delivery system for orthopaedic infections. CLAP is a direct continuous infusion of high-concentration gentamicin (1,200 μg/ml) into the bone marrow. As it is a new system, its influence on the bone marrow is unknown. This study aimed to examine the effects of high-concentration antibiotics on human bone tissue-derived cells. METHODS: Cells were isolated from the bone tissue grafts collected from six patients using the Reamer-Irrigator-Aspirator system, and exposed to different gentamicin concentrations. Live cells rate, apoptosis rate, alkaline phosphatase (ALP) activity, expression of osteoblast-related genes, mineralization potential, and restoration of cell viability and ALP activity were examined by in vitro studies. RESULTS: The live cells rate (the ratio of total number of cells in the well plate to the absorbance-measured number of live cells) was significantly decreased at ≥ 500 μg/ml of gentamicin on day 14; apoptosis rate was significantly increased at ≥ 750 μg/ml, and ALP activity was significantly decreased at ≥ 750 μg/ml. Real-time reverse transcription-polymerase chain reaction results showed no significant decrease in the ALP and activating transcription factor 4 transcript levels at ≥ 1,000 μg/ml on day 7. Mineralization potential was significantly decreased at all concentrations. Restoration of cell viability was significantly decreased at 750 and 1,000 μg/ml on day 21 and at 500 μg/ml on day 28, and ALP activity was significantly decreased at 500 μg/ml on day 28. CONCLUSION: Our findings suggest that the exposure concentration and duration of antibiotic administration during CLAP could affect cell functions. However, further in vivo studies are needed to determine the optimal dose in a clinical setting.Mar. 2024, Bone & joint research, 13(3) (3), 91 - 100, English, International magazineScientific journal
- Introduction We introduced a novel numerical index known as posterior protrusion measures (PPM), derived from lateral plain radiograph images, which effectively serves to distinguish stable from unstable pertrochanteric fractures. The present study aims to scrutinize PPM values among two classified fracture patterns, stable and unstable, within the three-dimensional (3D) CT classification system, establishing a numeric threshold for PPM to differentiate between these groups; explore the potential relationship between the PPM index and unclassified categories; investigate how groups divided by the PPM threshold value can predict fracture stability based on 3D CT. Materials and methods In this study, three observers were tasked with measuring PPM on a single occasion. The chi-square test assessed the association between each demographic parameter on a categorical scale and stable/unstable groups. Continuous variables were also subject to examination. Receiver operating characteristic (ROC) analysis was employed to determine optimal cut-off points of PPM for predicting the presence of stable versus unstable groups. Additionally, the chi-square test examined the linear relation between separated groups based on the defined threshold PPM value and the stable/unstable groups. Results A total of 106 pertrochanteric fractures were identified using CT scan images and plain radiographs in the 3D CT classification system, revealing the stable group of 35 patients and the unstable group of 71 patients. The PPM values for stable/unstable fractures were, on average (± standard deviation), 0.34±0.25/0.50±0.29 for observer 1, 0.31±0.23/0.57±0.31 for observer 2, and 0.41±0.29/0.57±0.26 for observer 3, respectively (p<0.01). We established 0.3 as the cut-off value for PPM. The average PPM value among three observers represented each patient to assess fracture stability. The group with PPM <0.3 included 27 patients (16 stable and 11 unstable), and the group with PPM ≥0.3 group comprised 79 patients (19 stable and 60 unstable; p<0.005). Conclusion The present study revealed a significant difference in PPM values among stable and unstable 3D CT classification groups. Additionally, a threshold PPM value of 0.3 suggests a pivotal point for differentiating fracture stability. This innovative methodology makes a substantial contribution to clinical endeavors, potentially circumventing the necessity for 3D CT scanning.Dec. 2023, Cureus, 15(12) (12), e51363, English, International magazineScientific journal
- (株)メジカルビュー社, Nov. 2023, 関節外科, 42(11) (11), 1295 - 1302, Japanese
- BACKGROUND: We previously demonstrated that CD34 + cell transplantation in animals healed intractable fractures via osteogenesis and vasculogenesis; we also demonstrated the safety and efficacy of this cell therapy in an earlier phase I/II clinical trial conducted on seven patients with fracture nonunion. Herein, we present the results of a phase III clinical trial conducted to confirm the results of the previous phase studies using a larger cohort of patients. METHODS: CD34 + cells were mobilized via administration of granulocyte colony-stimulating factor, harvested using leukapheresis, and isolated using magnetic cell sorting. Autologous CD34 + cells were transplanted in 15 patients with tibia nonunion and 10 patients with femur nonunion, who were followed up for 52 weeks post transplantation. The main outcome was a reduction in time to heal the tibia in nonunion patients compared with that in historical control patients. We calculated the required number of patients as 15 based on the results of the phase I/II study. An independent data monitoring committee performed the radiographic assessments. Adverse events and medical device failures were recorded. RESULTS: All fractures healed during the study period. The time to radiological fracture healing was 2.8 times shorter in patients with CD34 + cell transplantation than in the historical control group (hazard ratio: 2.81 and 95% confidence interval 1.16-6.85); moreover, no safety concerns were observed. CONCLUSIONS: Our findings strongly suggest that autologous CD34 + cell transplantation is a novel treatment option for fracture nonunion. TRIAL REGISTRATION: UMIN-CTR, UMIN000022814. Registered on 22 June 2016.Oct. 2023, BMC medicine, 21(1) (1), 386 - 386, English, International magazineScientific journal
- (株)医学書院, Jun. 2023, 臨床整形外科, 58(6) (6), 787 - 797, Japanese
- Bone-modifying agents (BMAs), with bone-resorptive inhibitory effects, such as zoledronic acid and denosumab, are widely used at higher doses for bone-related events caused by bone metastasis of malignant tumors. These drugs have been suggested to be associated with atypical femoral fractures (AFFs), and the relationship between BMAs and AFFs has attracted attention. To investigate the clinical features including bone union time of AFFs in patients administered BMA for bone metastasis, we conducted a retrospective multicenter study. Thirty AFFs from 19 patients were enrolled in this study. Thirteen patients had bilateral AFFs, and nineteen AFFs had prodromal symptoms. Eighteen AFFs underwent surgery after complete fracture, three failed to achieve bone union and required nonunion surgery, and 11 AFFs that achieved bone union had an average period until bone union of 16.2 months, which was much longer than that previously reported for ordinary AFFs. Seven patients discontinued the BMAs, but not due to AFFs. Stopping BMAs in patients with bone metastasis would make it difficult to secure their performance of activities of daily living, and AFF with BMA administration might require a longer time for union. Therefore, it would be important to prevent incomplete AFF from becoming complete AFF via prophylactic internal fixation.Jun. 2023, Journal of bone oncology, 40, 100478 - 100478, English, International magazineScientific journal
- INTRODUCTION: The Masquelet technique is a relatively new method for large bone defect treatment. In this technique, grafted bone tissue is used, and after the cement is removed, the induced membrane (IM; that form around the cement spacers placed in the bone defect region) is thought to play an important role in promoting bone formation. On the other hand, low-intensity pulsed ultrasound (LIPUS) is known to promote fracture healing and angiogenesis through mechanical stimulation. This study aimed to investigate the in vitro effects of LIPUS on the osteogenic differentiation of human induced membrane-derived cells (IMCs). METHODS: Seven patients who had been treated using the Masquelet technique were enrolled. The IM was harvested during the second stage of the technique. IMCs were isolated, cultured in growth medium, and then divided into two groups: (1) control group, IMCs cultured in osteogenic medium without LIPUS, and (2) LIPUS group, IMCs cultured in osteogenic medium with LIPUS treatment. Adherent cells from the IM samples were harvested after the first passage and evaluated for cell surface protein expression using immunostaining. A cell proliferation assay was used to count the number of IMCs using a hemocytometer. Osteogenic differentiation capability was assessed using an alkaline phosphatase (ALP) activity assay, Alizarin Red S staining, and real-time reverse transcription-polymerase chain reaction. RESULTS: Cell surface antigen profiling revealed that the IMCs contained cells positive for the mesenchymal stem cell-related markers CD73, CD90, and CD105. No significant difference in cell numbers was found between the control and LIPUS groups. The ALP activity of IMCs in the LIPUS group was significantly higher than that in the control group on days 7 and 14. Alizarin red S staining intensity was significantly higher in the LIPUS group than in the control group on day 21. Runx2 and VEGF expression was significantly upregulated on days 7 and 14, respectively, compared with levels in the control group. CONCLUSION: We demonstrated the significant effect of LIPUS on the osteogenic differentiation of human IMCs. This study indicates that LIPUS can be used as an additional tool for the enhancement of the healing process of the Masquelet technique.Apr. 2023, Injury, English, International magazineScientific journal
- (公社)日本整形外科学会, Apr. 2023, 日本整形外科学会雑誌, 97(4) (4), 252 - 260, Japanese
- A Hoffa fracture is a rare type of femoral fracture that is difficult to treat. Nonoperative treatments usually result in failure; hence, in most cases, surgical treatments are essential. Nonunion following Hoffa fracture appears to be relatively uncommon, and there are limited reports in the literature about this type of nonunion. These reports suggest that open reduction and rigid internal fixation is the standard treatment for this type of nonunion. This study reports the case of a 61-year-old male patient who suffered from left lateral Hoffa fracture after falling from a truck bed. At the former hospital, open reduction and internal fixation were performed with plates and screws at 8 days post-injury. Postoperatively, displacement of the lateral proximal fragment was observed, and the patient reported left knee pain. Therefore, a revision open reduction and internal fixation was performed 4 months post-surgery. However, 6 months after the revision surgery, the patient reported instability and pain in the left knee, and subsequent radiography revealed nonunion of the fracture in the lateral condyle. The patient was referred to our hospital for further treatment. Treatment by re-revision open reduction and internal fixation was deemed challenging, and so rotating hinge knee (RHK) arthroplasty was performed as a salvage treatment. At 3 years post-surgery, no significant problems were observed, and the patient could walk without any assistance. The range of motion of the left knee was 0 to 100° without extension lag, and there was no lateral instability. Standard treatment for Hoffa fracture nonunion is commonly anatomical reduction and rigid internal fixation. However, total knee arthroplasty may be a better option for the treatment of Hoffa fracture nonunion in older patients.Mar. 2023, Cureus, 15(3) (3), e35780, English, International magazine
- Introduction In a preliminary study of cephalo-medullary (CM) nailing in patients with femoral intertrochanteric fractures, the authors of this study found a 25% to 30% decrease in muscle strength, especially abduction force, during the postoperative follow-up period. This decline was partially attributed to the entry point for the nail insertion causing damage to the gluteus medius tendon at the junction of the greater trochanter after reaming. Therefore, we assumed that changing the position of nail insertion to a "bald spot (BS)" could mitigate postoperative functional impairment. Automated computed tomography (CT) imaging of skeletal muscle cross-sectional area (CSA) and adipose tissue ratio (ATR) can show pathological changes on the operated side compared with the non-operated side. In this study, the authors quantified the difference in postoperative CSA and ATR of the gluteus medius muscle after bald spot nailing versus nail insertion through the conventional tip of the greater trochanter. It was hypothesized that bald spot nailing could avoid significant injury to the gluteus medius muscle. Materials and methods Patients with femoral intertrochanteric fractures were grouped according to the site of cephalo-medullary nailing: greater trochanteric tip (TIP) in 27 patients (8 men and 19 women, mean age 84.9±5.1 years) and BS in 16 patients (3 men and 13 women, mean age 86.9±6.2 years). The CSA and ATR of the gluteus medius muscles were assessed in three slices (A, B, and C from proximal to distal). Each slice was manually traced and automatically calculated based on its contour. Adipose tissue (-100 to -50 in Hounsfield units) in the designated area was distinguished by a bimodal image histogram resulting from the distribution of CT numbers of adipose tissue and muscle. The body mass index (BMI) was used to correct the CSA in each patient. Results In the TIP group, the mean CSA values (mm2) from the non-operated/operated sides were as follows: slice A, 2180.2 ± 616.5/1976.3 ± 421.2; slice B, 2112.3 ± 535.7/1857.7 ± 386.7; and slice C: 1671.8 ± 460.0/1404.1 ± 404.3 (p<0.01 in slices A, B, and C). In the BS group, slice A was 2044.1 ± 473.0/2016.9 ± 388.4; slice B was 2073.2 ± 540.7/1848.3 ± 411.1; and slice C was 1659.1 ± 477.2/1468.5 ± 341.7 (p=0.34 in slice A, and p<0.05 in slices B and C, respectively). The mean CSA values (mm2) of the non-operated minus operated side between the TIP/BS groups were as follows: slice A, 241.3 ± 424.3/-11.8 ± 285.6; slice B, 290.3 ± 313.0/211.8 ± 333.2; and slice C, 276.4 ± 270.4/162.8 ± 319.3 (p < 0.05 in slice A, 0.45, 0.24 in slices B, C, respectively). The mean adjusted CSA per BMI values (mm2) of the non-operated minus the operated side between the TIP/BS groups were slice A, 10.6 ± 19.7/-0.4 ± 14.8; slice B, 13.3 ± 15.0/10.1 ± 16.3; and slice C, 13.1 ± 13.4/ 8.7 ± 15.3 (p < 0.05 in slice A and 0.54 and 0.36 in slices B and C, respectively). Conclusion Nail insertion at the bald spot resulted in a significantly smaller decrease in the CSA of the gluteus medius muscle compared with the conventional tip entry. In addition, an examination of BMI-adjusted CSA showed that CSA was maintained in some image slices. These results suggest that nailing from the BS of the greater trochanter can reduce damage to the gluteus medius muscle and highlight the importance of imaging beyond the usual assessment of skeletal changes.Mar. 2023, Cureus, 15(3) (3), e36103, English, International magazineScientific journal
- Introduction A demographic survey of femoral pertrochanteric fractures provides several important information for the healthcare system of a country since this fracture is commonly seen in the elderly and has a poor postoperative functional prognosis that is a burden on society. The importance of accurately classifying pertrochanteric fractures as stable or unstable cannot be understated. However, the use of plain radiograph images alone is known to underestimate fracture severity with low inter- or intra-observer agreement. Computed tomography (CT) images offer information for a more accurate classification of pertrochanteric fractures. With this three-dimensional (3D) CT-based study using the revised Arbeitsgemeinschaft für Osteosynthesefragen/Orthopedic Trauma Association (AO/OTA) classification, the purpose of this study is to elucidate the epidemiological demography of patients with pertrochanteric fractures. Material and methods We retrospectively collected 808 patients from five hospitals, classified into two groups: stable (A1) or unstable (A2). Age, gender, fracture laterality, and surgery timing were identified as epidemiological variables. Patients with both preoperative plain radiographs and 3D CT scans were included in the study. The exclusion criteria were AO/OTA A3 type fractures, pathological fractures, previous ipsilateral surgery, 60 years old or younger, and conservatively treated patients. The primary outcome involved detailing the total number of fractures based on classification (A1 or A2) and variables. The secondary outcome involved a comparison between the A1 and A2 groups. Results The mean age of patients at the time of surgery was 85 years (range: 61-103 years). There were 637 female and 171 male patients. There were 463 left-sided fractures and 345 right-sided fractures. Of the 808 patients, 371 (45.9%) were classified to have A1 fractures, and 437 (54.1%) had A2 fractures. The age at surgery, gender, fracture laterality, and surgery timing between the A1 and A2 groups were compared. The mean and standard deviation of the age at surgery for patients in the A1 and A2 groups were 84.9±7.7 and 86.9±6.8, respectively. The number of patients for each age distribution of 61-69, 70-74, 75-79, 80-84, 85-89, 90-94, and 95 or older for the A1 and A2 groups was 18 and 7, 18 and 12, 43 and 44, 76 and 82, 107 and 132, 79 and 110, and 30 and 50, respectively, showing that the difference in categorial distribution was statistically significant (p=0.002). Overall, 278 females and 93 males were classified to have A1 fractures compared with 359 females and 78 males with A2 fractures (p=0.01). There were 166 right-sided and 205 left-sided stable A1 fractures and 179 right-sided and 258 left-sided A2 fractures (not significant (NS)). Among the total number of A1 and A2 surgeries by month, the most were in December with 77 surgeries (37 and 40, respectively), and the least was in June with 37 (18 and 19, respectively). The seasonal classification for A1 and A2 surgeries is as follows: spring with 172 (74 and 98, respectively), summer with 150 (70 and 80, respectively), autumn with 193 (90 and 103, respectively), and winter with 208 (97 and 111, respectively) (NS). Conclusion In this demographic study of 808 patients with pertrochanteric fractures classified by 3D CT images, 371 had A1 fractures and 437 had A2 fractures. A2 fractures were significantly more in females with an age peak of 85-89 years.Jan. 2023, Cureus, 15(1) (1), e33572, English, International magazineScientific journal
- Introduction The absence of a precise fracture classification system that classifies pertrochanteric fractures into either stable or unstable contributes to a burden on healthcare and has several major implications. We propose an innovative graphical index, which we refer to as posterior protrusion measures (PPM), using plain lateral view radiograph images for the revised AO Foundation (Arbeitsgemeinschaft für Osteosynthesesfragen)/Orthopedic Trauma Association (AO/OTA) classification system. This study aims to: (i) introduce the use of PPM for classifying fractures into stable or unstable under the revised AO/OTA classification system and set the threshold numeric value, (ii) elucidate the reproducibility of inter and intra-observer agreement, and investigate the consistency of fracture classification using PPM versus computed tomography (CT) scan images. Materials and methods Out of 146 patients identified from the database, a total of 126 patients were enrolled in the study. Pertrochanteric fractures were classified as either stable or unstable. Three surgeons were assigned for PPM determination. Regarding the demographical data, the chi-square test was used to assess the significance of each parameter on a categorical scale between the two groups. The independent sample t-test or the Mann-Whitney U test was used to compare the two independent groups. Interclass correlation coefficient (ICC) values for continuous variables and kappa values (κ) for categorical variables were calculated to assess inter-observer and intra-observer agreement. Receiver-operating characteristic (ROC) analysis was used to determine optimal cut-off points of PPM to predict consistency between separate fracture classification groups, one using PPM values with a threshold derived from plain radiograph images, and the other using CT scan images. Results Among a total of 126 pertrochanteric fractures, the A1 (stable) group consisted of 39 patients (10 males, 29 females), whereas the A2 (unstable) group consisted of 87 patients (14 males, 73 females) (not significant, NS). Intraclass correlation coefficient (ICC) values of PPM for the inter-observer agreement were 0.796 (0.723-0.852), 0.664 (0.554-0.751), and 0.702 (0.601-0.781) at first examination and 0.729 (0.635-0.801) at the second. The intra-observer agreement was 0.869 (0.819-0.906) and 0.603 (0.480-0.703). We examined for consistency of fracture classification group of PPM values with a threshold of 0.4 (A1<0.4, A2=0.4 or more) and CT-based group. For the first examination, there was mostly "moderate" agreement in fracture classification (stable or unstable) between plain radiograph and CT scan images, κ (95%CI): 0.427 (0.266-0.588), 0.493 (0.335-0.651), and 0.359 (0.176-0.544), and for the second, 0.418 (0.251-0.585), and 0.451 (0.284-0.620), respectively. Conclusion We propose a supplementary tool, namely PPM that allows for possible alternative classification of pertrochanteric fractures into A1 (stable) and A2 (unstable) using plain radiograph images under the revised AO/OTA classification system. In this study, a PPM threshold value of 0.4 demonstrated a moderate inter- and intra-observer agreement. It is noteworthy to mention that there was a satisfactory consistency of fracture classification using PPM derived from plain radiograph images when compared to classification using CT scan images. In addition, the PPM method provides a numerical score.Dec. 2022, Cureus, 14(12) (12), e32898, English, International magazineScientific journal
- INTRODUCTION: Osteomyelitis pubis is a rare disease that presents with fever, pubic or hip pain, pain during hip movement, and claudication to avoid pain. It most frequently affects young athletes involved in sports that require twisting and cutting, but its exact cause is unknown and no definite treatment has been established. We report a case of pubic osteomyelitis in a young football player who was treated using the Masquelet technique and antibiotics with a good clinical course. CASE REPORTS: A 22-year-old male football player in a national-level university club team visited a nearby clinic complaining of high fever and mild pain in his bilateral hip joints. As a result of examination, we diagnosed osteomyelitis pubis and reconstructed the pubic symphysis by the Masquelet technique. In this case, the joint-like structure of the pubic symphysis was successfully reconstructed, and the patient was able to continue playing the sport. Three years and 3 months after surgery, he had no limitation of bilateral hip joint range of motion and did not display any symptoms while playing football. CONCLUSION: Masquelet technique could be a novel surgical method for managing osteomyelitis pubis, even in athletes.Dec. 2022, Journal of orthopaedic case reports, 12(12) (12), 39 - 42, English, International magazine
- When visualizing biological activity at nonunion sites by the radioisotopes, gamma rays are more attenuated if metal implants are placed in the bone. However, the effects of various implant types and their placement on gamma ray attenuation in quantitative evaluation remain unknown. To elucidate these effects, we created a phantom that simulated the nonunion of the femur in this study. The count of gamma rays was measured by single-photon emission computed tomography/computed tomography (SPECT/CT) while considering CT-based attenuation correction (CTAC), metal implant placement, type (intramedullary nail or plate), and position. The count differed significantly with and without CTAC and with and without implants (both types) under CTAC. Significantly different counts were observed between the intramedullary nail and plate placed contralaterally to the lesion (i.e., non-lesion side). No significant difference was observed between the intramedullary nail and plate on the lesion side or between plates on the non-lesion and lesion sides. The measured standardized uptake value (SUV) was closer to the true SUV with CTAC than without. Moreover, the count was higher with implants than without. However, even with implants, it was lower than the actual count, indicating the absence of overcorrection. Implant type and position do not seem to influence the count.Nov. 2022, Journal of clinical medicine, 11(22) (22), English, International magazineScientific journal
- In this study, we examined the proliferation capability and osteogenic and chondrogenic differentiation potential of non-hypertrophic nonunion cells (NHNCs), and the effect of Escherichia coli-derived BMP-2 (E-BMP-2) on them. We enrolled five patients with non-hypertrophic nonunion. NHNCs isolated from nonunion tissue sampled during surgery were cultured, passaged, counted every 14 days, and analyzed. NHNCs were homogenous fibroblastic adherent cells and long-lived through at least 10 passages, with a slight decline. The cells were consistently positive for mesenchymal stem cell-related markers CD73 and CD105, and negative for the hematopoietic markers CD14 and CD45. NHNCs could differentiate into osteoblast lineage cells; however, they did not have strong calcification or sufficient chondrogenic differentiation capability. E-BMP-2 did not affect the proliferative capability of the cells but improved their osteogenic differentiation capability by increasing alkaline phosphatase activity and upregulating the gene expression of osterix, bone sialoprotein, and osteocalcin. E-BMP-2 enhanced their chondrogenic differentiation capability by upregulating the gene expression of aggrecan and collagen type II. We showed, for the first time, that NHNCs have the capacity to differentiate into osteoblast-lineage cells, although the chondrogenic differentiation potential was poor. Local application of E-BMP-2 with preservation of nonunion tissue is a potential treatment option for non-hypertrophic nonunion.Nov. 2022, Current issues in molecular biology, 44(11) (11), 5562 - 5578, English, International magazineScientific journal
- INTRODUCTION: The etiology of Klippel-Trenaunay syndrome (KTS) has a significant impact on the management of patient requiring surgical interventions. We report the strategies employed to address an infected non-union in a patient with KTS. CASE REPORT: The patient was transported to an initial treating hospital with femoral shaft fracture after experiencing a fall. The patient was diagnosed with KTS due to vascular malformations identified after severe intraoperative hemorrhaging. An open reduction and internal fixation was performed to stabilize the bone. Nine months after surgery, the patient was transferred to our hospital due to lack of healing with infected non-union. We prioritized treating the infection and plate displacement, and subsequently performed intramedullary nailing. Infection and intraoperative hemorrhaging were successfully controlled and bone union was confirmed 6 months after surgery. CONCLUSION: The key factors to minimize procedural complications are sufficient preoperative evaluation and planning, surgical skill, and perioperative resource management.Jul. 2022, Journal of orthopaedic case reports, 12(7) (7), 38 - 41, English, International magazine
- For the prevention of surgical site infection (SSI), continuous disinfection could be helpful. Short wavelength ultraviolet radiation C (UVC) is highly bactericidal but shows cytotoxicity. Radiation of UVC with a wavelength of 222 nm to the skin is considered to be safe because it only reaches the stratum corneum. However, the safety of 222 nm irradiation to the surgical field not covered with skin is unknown. The purpose of this study was to examine the safety of 222 nm UVC irradiation on a surgical field in a rabbit model. Five types of tissue were surgically exposed and irradiated with 222 or 254 nm UVC. Immunohistological assessment against cyclobutane pyrimidine dimer (CPD), an index of DNA damage by UVC, was performed. The CPD-positive cell rate was significantly higher in the 254 nm group than in the other groups in all tissues. A 222 nm group showed significantly more CPD than control in fat tissue, but no significant difference in all other tissues. In fat tissue collected 24 h after irradiation, the 254 nm group showed higher CPD than the other groups, while the 222 nm group had reduced to the control level. These data suggest that 222 nm UVC irradiation could be a new method to safely prevent SSI.Mar. 2022, Photochemistry and photobiology, 98(6) (6), 1365 - 1371, English, International magazineScientific journal
- American Society for Clinical Investigation, Mar. 2022, Journal of Clinical InvestigationScientific journal
- INTRODUCTION: We encountered a case of post-operative infection of an open tibial fracture that was controlled by continuous local antibiotic perfusion (CLAP), a novel method of fracture-related infection (FRI) that we have developed. CLAP is a procedure in which a bone marrow needle and a double lumen tube are placed in the infected area, and an appropriate concentration of antimicrobial agent is continuously administered and perfused. CASE REPORT: The patient was a 78-year-old woman. She was hit by a motor vehicle and fell to the farmyard floor. She suffered multiple traumas, including a lower leg open fracture, multiple rib fractures, clavicle fracture, pelvic fracture, mandibular fracture, and liver injury. Her tibial fracture was a Gustilo-Anderson type IIIA open fracture. After debridement and external fixation of the tibial open fracture on the same day, open reduction and internal fixation with an intramedullary nail was performed 3 days after the injury. Twelve days after the injury, local heat and redness were observed at the nail insertion wound and the posteromedial calf, and a purulent clot was discharged from the open wound. We performed curettage of the lesion and retained the implant. CLAP was then constructed to perfuse local antibiotics along the nail and large hematoma area. Locally, the inflammation improved and the inflammatory response became negative 3 weeks after the initiation of CLAP. Six months after surgery, bony union was achieved. At present, 3.5 years after the internal operation, there is no sign of infection, and the patient has returned to her pre-injury life with no abnormalities in motor function. CONCLUSION: CLAP may be a novel treatment method that can be expected to achieve bone healing while preserving the implant in FRI cases after open tibial fracture.Feb. 2022, Journal of orthopaedic case reports, 12(2) (2), 18 - 22, English, International magazine
- BACKGROUND: Induced membrane (IM) is the key component of Masquelet reconstruction surgery for the treatment of bone defects. IM is formed around the cement spacer and is known to secrete growth factors and osteoinductive factors. However, there is limited evidence available concerning the presence of osteoinductive factors in IM. This study aimed to investigate the existence of bone morphogenetic proteins (BMPs) in IM harvested from patients during the treatment of bone defects using the Masquelet technique. METHODS: This study involved six patients whose bone defects had been treated using the Masquelet technique. The affected sites were the femur (n = 3) and the tibia (n = 3). During the second-stage surgery, 1 cm2 pieces of IM were harvested. Histological sections of IM were immunostained with anti-BMP-4, 6, 7, and 9 antibodies. Human bone tissue served as the positive control. RESULTS: The presence of BMP-4, 6, 7, and 9 was observed in all IM samples. Further, immunolocalization of BMP-4, 6, 7, and 9 was observed in blood vessels and fibroblasts in all IM samples. Immunolocalization of BMP-4, 6, 7, and 9 was also observed in bone tissue within the IM in one sample, in which osteogenesis inside the IM was observed. CONCLUSIONS: This study showed that osteoinductive factors BMP-4, 6, 7, and 9 were present in the IM harvested from patients, providing evidence indicating that the Masquelet technique effectively contributes to healing large bone defects. Therefore, it may be possible for surgeons to omit the addition of BMPs to bone grafts, given the endogenous secretion of BMPs from the IM.Jan. 2022, Journal of orthopaedic surgery and research, 17(1) (1), 29 - 29, English, International magazineScientific journal
- We introduce a treatment that combines the cross-leg free flap with the Masquelet technique and describe two cases using this method for bone and soft tissue reconstruction. Both patients were successfully treated and ambulatory. This novel method can be safely performed using the delay technique, indocyanine-green angiography and near-infrared spectroscopy.2022, Case reports in plastic surgery & hand surgery, 9(1) (1), 99 - 104, English, International magazine
- PURPOSE: Fracture-related infections are difficult to treat because of the formation of biofilms around implants. Systemic antibiotics are notoriously ineffective against biofilms due to their insufficient penetration of tissues with poor vascularity. The goal of treating fracture-related infections is to achieve bone union while retaining the implant. Our proposal of continuous local antibiotic perfusion is a sustained local delivery system of sufficient antibiotics to bone and soft tissue infection sites, including to bone marrow via needles as intra-medullary antibiotics perfusion and to soft-tissue via double-lumen subcutaneous tubes as intra-soft tissue perfusion. METHODS: In this study, we examined the outcomes of 40 patients treated for fracture-related infections using continuous local antibiotic perfusion between 2015 and 2021 at Steel Memorial Hirohata Hospital, Himeji, Japan. RESULT: The antibiotic used for continuous local antibiotic perfusion was gentamicin in all cases. Implant removal was required in five patients. Two patients required toe amputation and knee arthrodesis, while the remaining 38 patients achieved fracture union. Only one case of transient acute renal injury as a systemic side effect was observed, but it soon resolved. The blood concentration of gentamicin could be adjusted to less than the trough level. CONCLUSIONS: Continuous local antibiotic perfusion is a novel local drug delivery system that has the potential of delivering sufficient concentrations of antibiotics with few systemic side effects; it is a useful option for the treatment of fracture-related infections.2022, Journal of orthopaedic surgery (Hong Kong), 30(2) (2), 10225536221111902 - 10225536221111902, English, International magazineScientific journal
- 2022, ICMLC, 259 - 264International conference proceedings
- Introduction: We report a very rare case of nonunion with ballooning deformity of the humeral bone after a periprosthetic humeral fracture nonunion. Case Report: A 79-year-old woman underwent hemiarthroplasty 19 years ago for her proximal humerus fracture. She injured her right humeral diaphysis (stem distal end fracture) 6 years ago. She underwent revision hemiarthroplasty with long stem, but bony union was not obtained, and her right upper limb function was subsequently abolished due to extreme instability and pain in her right upper arm. She was then referred to our hospital for further treatment. X-ray showed nonunion in the humeral diaphysis and a severe ballooning deformity in the distal humeral bone fragment. Due to the advanced age and low activity of the patient, we chose total humerus replacement surgery instead of osteosynthesis. After the surgery, her upper arm pain and instability immediately improved. Three years after the last surgery, there have been no implant failures, and the upper arm is stable and painless. Conclusion: Although there are some reports of total humerus replacement as surgical treatment for humeral tumor and severe periprosthetic fracture, we found no reports of such ballooning deformity around the nonunion site. Total humerus replacement can be one of the treatment options in cases where nonunion surgery is extremely difficult, depending on the patient's age and activities of daily living.Jan. 2022, Journal of orthopaedic case reports, 12(1) (1), 89 - 91, English, International magazine
- Introduction: Chronic osteomyelitis is difficult to cure definitively, because local areas are often covered with sequestrum and scar tissues with a poor blood flow; these may render systemic antibiotic administration ineffective. We present a case of chronic osteomyelitis that was successfully treated with continuous local antibiotic perfusion (CLAP) through an intramedullary antibiotic perfusion (iMAP) pin. Case Presentation: A 65-year-old man who suffered an episode of the right femoral osteomyelitis at the age of 15 years experienced a relapse at the age of 63 years. Systemic administration of antibiotics could not control the infection; thus, a surgery was performed. A bone marrow needle (i.e., an iMAP pin; diameter: 3 mm) was percutaneously inserted, from the front, distally and proximally to the cystic lesion in the distal femur. After washing through the iMAP pins, the pins were left indwelling. A closed drain tube was placed on the bone surface, which was close to the fistula of the bone marrow lesion. CLAP therapy was then initiated. Gentamicin was continuously infused through the iMAP pin at a rate of 2 mL/h and drained using the tube. Accordingly, 2.4 mg/mL, 1.2 mg/mL, and 1.2 mg/mL of gentamicin were administered for 4 days using two iMAP pins, for 5-8 days using two iMAP pins, and for 9-15 days using one iMAP pin, respectively, with a syringe pump. The iMAP pins and the drain tube were removed 15 days after the initiation of the CLAP therapy. The C-reactive protein level normalized 25 days postoperatively. The patient recovered full range of motion of the knee joint and recreational sports activity without recurrence of osteomyelitis for 5 years after the therapy. Conclusions: CLAP therapy allows local administration of a sufficient concentration of antibiotics and device removal after treatment is simple. This may be a novel treatment for chronic osteomyelitis.Dec. 2021, Journal of orthopaedic case reports, 11(12) (12), 35 - 38, English, International magazine
- Recently, reamer-irrigator-aspirator (RIA) systems have been increasingly used to harvest autologous bone grafts. RIA graft materials contain bone marrow, which provides a viable source to derive large numbers of mesenchymal stem cells. Low-intensity pulsed ultrasound (LIPUS) significantly accelerates the differentiation of stem cells derived from bone marrow. This in vitro study investigated the effect of LIPUS on the osteogenic activity and differentiation of RIA graft-derived cells. A small amount of RIA graft was obtained from seven patients. After the cells derived from RIA grafts were cultured, they were divided into two groups: the LIPUS and control groups. LIPUS was applied once daily for 20 min (1.5 MHz, pulse duration: 200 µs, pulse repetition rate: 1 kHz, spatial average-temporal average intensity: 30 mW/cm2). Alkaline phosphatase activity (113.4% and 130.1% on days 7 and 14), expression of osteoblast-related genes (ALP, Runx2) and mineralization (135.2% on day 21) of the RIA graft-derived cells were significantly higher in the LIPUS group than in the control group. However, LIPUS did not affect the cell proliferation of RIA graft-derived cells. This study indicates that LIPUS may enhance the healing of non-union and critical bone defects treated by autologous bone grafting using the RIA system.Nov. 2021, Ultrasound in medicine & biology, 48(2) (2), 313 - 322, English, International magazineScientific journal
- The use of induced pluripotent stem cells (iPSCs) shows potential in bone regenerative strategies. In this study, we investigated whether implantation of chondrogenically differentiated iPSC-derived mesenchymal stem cells (iMSCs) can lead to successful bone regeneration in nude mice with bone defects. Two human iPSC clones (201B7 and 454E2) were used. After generating iMSCs, chondrogenic differentiation was achieved by three-dimensional pellet culture. Thereafter, a 2-mm defect was created in the radius of nude mice, and chondrogenically differentiated iMSC pellets were transplanted in the defect. Microcomputed tomography imaging was performed 8 weeks posttransplantation to assess bone regeneration. All (100%) radii in the 201B7 cell-derived pellet transplantation group and 7 of 10 (70%) radii in the 454E2 cell-derived pellet transplantation group showed bone union. In contrast, 2 of 11 radii (18%) in the control group showed bone union. Thus, the experimental groups showed significantly higher bone union rates than the control group (p < 0.05). Histological analysis 2 weeks postimplantation in the experimental groups revealed hypertrophic chondrocytes within grafted iMSC pellets and the formation of woven bone around them. This hypertrophic chondrocyte transitioning to newly formed bone suggests that the cartilaginous template can trigger endochondral bone ossification (ECO). Four weeks postimplantation, the cartilage template was reduced in size; newly formed woven bone was predominant in the defect site. New vessels were surrounded by a matrix of woven bone, and hypertrophic chondrocytes transitioning to newly formed bone indicated the progression of ECO. Eight weeks postimplantation, the pellets were completely resorbed and replaced by bone; complete bone union was observed. Dense mature bone developed with evidence of lamellar-like bone formation. Collectively, our results suggest that using iMSC-based cartilage grafts recapitulating the morphogenetic process of ECO in the context of embryonic skeletogenesis is a promising strategy for repairing large bone defects.Sep. 2021, Tissue engineering. Part A, 28(3-4) (3-4), 184 - 195, English, International magazineScientific journal
- (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1814 - S1814, Japanese
- Fractures associated with osteoporosis are a major public health concern. Current treatments for fractures are limited to surgery or fixation, leading to long-term bedrest, which is linked to increased mortality. Alternatively, utilization of physical agents has been suggested as a promising therapeutic approach for fractures. Here, we examined the effects of ultrasound, radial extracorporeal shock waves, and electrical stimulation on normal or osteoporotic fracture healing. Femoral bone defects were created in normal or ovariectomized rats. Rats were divided into four groups: untreated, and treated with ultrasound, shock waves, or electrical stimulation after surgery. Samples were collected at 2 or 4 weeks after surgery, and the healing process was evaluated with micro-CT, histological, and immunohistochemical analyses. Ultrasound at intensities of 0.5 and 1.0 W/cm2 , but not 0.05 W/cm2 , accelerated new bone formation. Shock wave exposure also increased newly formed bone, but formed abnormal periosteal callus around the defect site. Conversely, electrical stimulation did not affect the healing process. Ultrasound exposure increased osteoblast activity and cell proliferation and decreased sclerostin-positive osteocytes. We demonstrated that higher-intensity ultrasound and radial extracorporeal shock waves accelerate fracture healing, but shock wave treatment may increase the risk of periosteal callus formation.Aug. 2021, Annals of the New York Academy of Sciences, 1497(1) (1), 3 - 14, English, International magazineScientific journal
- Current treatment options for osteoporosis primarily involve pharmacotherapies, but they are often accompanied by undesirable side effects. Utilization of mechanical stress which can noninvasively induce bone formation has been suggested as an alternative to conventional treatments. Here, we examined the efficacy of mechanical stress induced by electrical stimulation, radial extracorporeal shock waves, and ultrasound for estrogen-deficient osteoporosis. Female Wistar rats were divided into following five groups: sham-operated group, untreated after ovariectomy, and treated with electrical stimulation, radial extracorporeal shock wave, or ultrasound starting at 8 weeks after ovariectomy for 4 weeks. Trabecular bone architecture of the femur was assessed by micro-CT and its biomechanical properties were obtained by mechanical testing. The femurs were further evaluated by histochemical, immunohistochemical, and real-time PCR analyses. Radial extracorporeal shock wave and ultrasound treatment improved trabecular bone microarchitecture and bone strength in osteoporotic rats, but not electrical stimulation. The shock wave decreased osteoclast activity and RANKL expression. The exposure of ultrasound increased osteoblast activity and β-catenin-positive cells, and they decreased sclerostin-positive osteocytes. These findings suggest that mechanical stress induced by radial extracorporeal shock wave and ultrasound can improve estrogen-deficient bone loss and bone fragility through promoted bone formation or attenuated bone resorption.Aug. 2021, Calcified tissue international, 109(2) (2), 215 - 229, English, International magazineScientific journal
- Aug. 2021, Calcified tissue international, 109(2) (2), 230 - 230, English, International magazine
- Correct assessment of the bone healing process is required for the management of limb immobilization during the treatment of bone injuries, including fractures and defects. Although the monitoring of bone healing using ultrasound poses several advantages regarding cost and ionizing radiation exposure compared with other dominant imaging methods, such as radiography and computed tomography (CT), traditional ultrasound B-mode imaging lacks reliability and objectivity. However, the body structures can be quantitatively observed by ultrasound frequency-based methods, and therefore, the disadvantages of B-mode imaging can be overcome. In this study, we created a femoral bone hole model of a rat and observed the bone healing process using the quantitative ultrasound method and micro-CT, which provides a reliable assessment of the tissue microstructure of the bone. This study analyzed the correlation between these two assessments. The results revealed that the quantitative ultrasound measurements correlated with the CT measurements for rat bone healing. This ultrasound frequency-based method could have the potential to serve as a novel modality for quantitative monitoring of bone healing with the advantages of being less invasive and easily accessible. Impact statement Bone healing monitoring with ultrasound is advantageous as it is less invasive and easily accessible; however, the traditional B-mode method lacks reliability and objectivity. This study demonstrated that the proposed ultrasound frequency-based monitoring method can quantitatively observe bone healing and strongly correlates with the computed tomography measurements for rat bone healing. This method has the potential to become a reliable modality for monitoring bone healing.Jun. 2021, Tissue engineering. Part C, Methods, 27(6) (6), 349 - 356, English, International magazineScientific journal
- MDPI AG, May 2021, Symmetry, 13(5) (5), EnglishScientific journal
- BACKGROUND: A reamer irrigator aspirator (RIA) can be used to harvest substantial amounts of autologous bone and debride the intramedullary canal. Clinical experience using reamer irrigator aspirators in Japan is very limited. The applicability of the reamer irrigator aspirator head with a minimum diameter of 12 mm for Japanese people is often questioned as the Japanese are smaller than Americans and Europeans. There are no reports of complications in Japanese patients. This study aimed to retrospectively review clinical cases and describe reamer irrigator aspirator use in Japanese patients. METHODS: All patients for whom a reamer irrigator aspirator was used during surgery at our hospital between January 2014 and September 2018 were included. The patients' clinical and radiographic data were retrospectively reviewed. RESULTS: Data of 40 patients (42 cases) were collected. The reamer irrigator aspirator was used for bone graft harvesting in 32 cases, intramedullary debridement and irrigation in 9 cases, and reaming for exchange nailing in 1 case. The diameter of the reamer irrigator aspirator reamer head was 12 mm in 22 cases (53.7%), 12.5 mm in 4 cases (9.8%), 13 mm in 9 cases (22.0%), 13.5 mm in 1 case (2.4%), 14.0 mm in 1 case (2.4%), 14.5 mm in 1 case (2.4%), and 15 mm in 4 cases (9.8%). Mean intraoperative bleeding volume was 1158.6 mL (range, 100-3800 mL). We experienced no difficulty inserting the reamer irrigator aspirator into the intramedullary canals and no cases of insertion-related intraoperative fracture. Five cortical perforations (11.9%) were observed on postoperative computed tomography scans, although no patient was symptomatic. One case (2.4%) of postoperative femur fracture occurred. CONCLUSIONS: Reamer irrigator aspirators can be used in Japanese patients. Smaller reamer head sizes were mainly used in our experience. We should manage complications as in previous reports from Western countries.May 2021, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 26(3) (3), 459 - 465, English, Domestic magazineScientific journal
- Background and objectives: Internal fixation is one of the most effective methods for the treatment of proximal femur fractures. The migration of implants after the operation can seriously affect the reduction of treatment and even cause complications. Traditional diagnosis methods can not directly measure the extent of displacement. Methods: Based on the analysis of Hansson pins, this paper proposes a measurement method based on three-dimensional matching, which uses computerized tomography (CT) images of different periods of patients after the operation to analyze the implants' migration in three-dimensional space with the characteristics of fast speed and intuitive results. Results and conclusions: The measurement results show that the method proposed in this paper has more minor errors, more flexible coordinate system conversion, and more explicit displacement analysis than the traditional method of manually finding references in CT images and measuring displacement.Apr. 2021, Medicina (Kaunas, Lithuania), 57(5) (5), English, International magazineScientific journal
- BACKGROUND: Rich vascularity of the induced membrane (IM) is important for Masquelet reconstruction surgery. The factors affecting IM vascularity are not completely understood. This study aimed to investigate these factors using histological samples of human IMs. METHODS: We retrospectively evaluated 36 patients whose bone defects were treated using the Masquelet technique. Two clinical pathologists analyzed histological sections of IM pieces (1 cm2). The number of blood vessels per 1 mm2 was counted and compared among men and women, femur or tibia, with and without free flap surgery, antibiotic impregnation to the cement, osteogenesis inside the membrane, smoking, and diabetes mellitus. The number of blood vessels within the same patient was compared among different time points. Correlation analysis was performed among blood vessel numbers and patient age, duration of cement spacer placement, and histological grading scales (inflammation, foreign body reaction, and fibrosis). RESULTS: IM formation with rich vascularity and some inflammation, foreign body reaction, and fibrosis were histologically confirmed in all patients. We found 37.4 ± 19.1 blood vessels per 1 mm2. The number of blood vessels was significantly lower in patients with than in those without free flap surgery; it was higher in patients with osteogenesis inside the IM. No significant correlations were found in any of the analyses. CONCLUSION: Sex, patient age, smoking, diabetes mellitus, femur or tibia, duration of cement spacer placement, and antibiotic impregnation to the cement did not affect IM vascularization. IM vascularization was reduced in patients with than in those without free flap surgery.Apr. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 248 - 248, English, International magazineScientific journal
- Introduction: Hypophosphatemic osteomalacia can be overlooked or confused with other musculoskeletal disorders due to the variety of associated clinical, laboratory, and radiographic findings. If osteomalacia is diagnosed early and the fractures are not displaced, they often heal with nutritional supplements, but, if they progress to displaced fractures, they may require surgical intervention. Case Report: We present a case of secondary osteomalacia due to autoimmune polyendocrine syndrome Type 2 due to this condition, the patient developed bilateral tibial proximal fractures and her varus deformity had progressed. No clear indication of the timing for surgery for adults with osteomalacia has been reported. However, medical treatment improves the symptoms of osteomalacia and it is reported that in children, appropriate level of the serum phosphate (P) should be attained and maintained for the successful bone healing after osteotomy. Therefore, we prioritized pharmacological treatment and prescribed surgery after confirming that the value of serum phosphate P had been improved to recommended levels (2.5-3.5 mg/dl). We performed high tibial osteotomy for the right side and gradual correction by an external fixation for the left tibia, because of more severe deformation, and converted to an internal fixation to shorten the treatment period. During conversion, we performed the operation with a locking plate by the minimal invasive plate osteosynthesis method (MIPO). Conclusion: We conclude that the use of different deformity correction methods, depending on the degree of deformity, and the pharmacological treatment of osteomalacia may lead to favorable results.Apr. 2021, Journal of orthopaedic case reports, 11(4) (4), 14 - 17, English, International magazine
- BACKGROUND: Recently, a standardized uptake value (SUV) has been used to evaluate bone single-photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected nonunion to compare hypertrophic nonunion and non-hypertrophic nonunion using volume-based parameters. METHODS: We evaluated 23 patients with uninfected nonunion who underwent SPECT acquisition 3 h after an injection of 99mTc-hydroxymethylene diphosphonate or 99mTc-methylene diphosphonate from April 2014 to November 2019. We reconstructed the acquired data and performed voxel-based quantitative analysis using the GI-BONE software. Quantitative parameters, maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean) in the high and low uptake areas of nonunion were compared between hypertrophic nonunion and non-hypertrophic nonunion. The contralateral limb was used as a control, and the ratios of the quantitative parameters were calculated. RESULTS: The values for the quantitative parameters (high uptake area/low uptake area, respectively), SUVmax control ratio (12.13 ± 4.95/6.44 ± 4.71), SUVpeak control ratio (11.65 ± 4.58/6.45 ± 4.64), and SUVmean control ratio (11.94 ± 5.03/6.28 ± 4.95) for hypertrophic nonunion were higher than those for non-hypertrophic nonunion (7.82 ± 4.76/3.41 ± 2.09 (p = 0.065/0.12), 7.56 ± 4.51/3.61 ± 2.23 (p = 0.065/0.22), and 7.59 ± 5.18/3.05 ± 1.91 (p = 0.076/0.23)). CONCLUSIONS: SUVmax, SUVpeak, and SUVmean control ratios obtained from bone SPECT images can quantitatively evaluate the biological activity of nonunions and may be an effective evaluation method for treatment decisions, especially the necessity of autologous bone grafting.Feb. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 125 - 125, English, International magazineScientific journal
- PURPOSE: In our hospital, cases of bone and soft tissue infections have been treated with continuous local antibiotics perfusion that allows for continuous circulation of antibiotics throughout the infected lesion. We termed this treatment "intramedullary antibiotics perfusion (iMAP)" for bone infection such as fracture-related infection (FRI) and "intrasoft tissue antibiotics perfusion" for soft tissue infection. Many cases are treated with both modalities. To introduce iMAP, this study focused on the patients with FRI treated with iMAP and reviewed their treatment outcomes. METHODS: We included 10 patients with FRI treated with iMAP between 2004 and 2017. The iMAP needles were inserted near the infected lesion, and an aminoglycoside antimicrobial was continuously administered. Patient characteristics, pathogenic bacteria, administered antibiotics, duration of administration, concentrations of antibiotics in blood and leachate fluid, fracture union rate, implant retention rate, and complications were studied. RESULTS: The mean age of patients was 59.9 years, and the mean follow-up period was 2.5 years. Affected bones were the tibia (n = 8), humerus (n = 1), and fibula (n = 1). Deep infections developed on average 29.9 days after osteosynthesis. Pathogenic bacteria were methicillin-susceptible Staphylococcus aureus (n = 6), methicillin-resistant S. aureus (n = 2), and unknown (n = 2). Average iMAP duration was 17.1 days. In all patients, infection was eradicated while preserving the implants, and fracture union was achieved without complications. CONCLUSION: iMAP is a novel local drug delivery system allowing high concentrations of antibiotics to be administered without complications and is useful in the treatment of FRI.2021, Journal of orthopaedic surgery (Hong Kong), 29(3) (3), 23094990211051492 - 23094990211051492, English, International magazineScientific journal
- IEEE, 2021, ICMLC, 1 - 5International conference proceedings
- Tumor-induced osteomalacia (TIO) is a rare skeletal disease caused by hypersecretion of fibroblast growth factor 23 (FGF-23) from neoplasms of mesenchymal origin; patients with TIO present with insufficiency fractures, progressive bone pain, and delayed fracture unions. Herein, we report the case of a 48-year-old man with an insufficiency fracture in his left femoral neck associated with TIO. The causative tumor located in the patient's maxillary sinus had been resected; however, complete resection was impossible due to the location of the tumor. Therefore, the patient's osteomalacia persisted, and he experienced a left femoral neck fracture in the absence of severe trauma. Because delayed fracture union was anticipated in this patient, we performed an internal fixation using an implant with a lateral plate for angular stability and multiple screws for rotational stability. Although fracture union took 15 months, the patient's postoperative course was uneventful, and he could walk without any symptoms or assistance at his most recent follow-up 30 months after surgery. In TIO, hypersecretion of FGF-23 leads to increased renal excretion of phosphorus, increased bone resorption of calcium and phosphorus, decreased osteoblastic bone mineralization, and decreased gastrointestinal absorption of calcium and phosphorus, leading to insufficiency fractures and delayed fracture unions. Diagnosis of TIO is often delayed due to its rarity and vague symptoms. Total resection of the causative tumor is the optimal treatment; however, in cases wherein complete tumor resection is impossible, drug therapy may be insufficient, and the underlying TIO pathology, including bone fragility, may persist. Early diagnosis of TIO is important for preventing insufficiency fractures; however, when fractures are unavoidable, the surgical treatment of femoral neck fractures in patients with osteomalacia should account for a longer time frame for complete fracture union and therefore utilize implants with sufficient stability.2021, Case reports in orthopedics, 2021, 6668006 - 6668006, English, International magazine
- 金原出版(株), Jan. 2021, 整形・災害外科, 64(1) (1), 61 - 69, Japanese
- Introduction: Although the recommended treatment for humeral shaft nonunion is compression plating with autologous bone grafting, we treated a case of humeral shaft nonunion with an intramedullary nail (IMN) without bone grafting. Presentation of Case. Osteosynthesis with IMN was performed on a 24-year-old man with a humeral shaft fracture at another hospital. However, bony union was not obtained 1 year after the first surgery, and he was referred to our institution. We treated the nonunion with exchange nailing without autologous bone grafting using compression function of the nail, leading to bony union at 7 months postoperatively. At the final follow-up 2 years and 4 months postoperatively, the patient had full range of motion in the left shoulder and elbow joints. Discussion. Compression plating with autologous bone grafting is reported to be the gold standard for the treatment of humeral shaft nonunion. IMN is advantageous for minimal invasion; however, the conventional type of IMN cannot apply compression force between fragments and does not have sufficient stability against rotational force. In this case, we used an IMN that could apply compression between the fragments and which had rotational stability via many screws. We did not perform bone grafting because the current nonunion was adjudged to be biologically active, and we achieved good functional results. Conclusion: We treated humeral shaft nonunion using IMN with compression, but without bone grafting, leading to successful clinical outcomes. This strategy might be an appropriate choice for the treatment of humeral shaft nonunion with biological activity.2021, Case reports in orthopedics, 2021, 5548729 - 5548729, English, International magazine
- INTRODUCTION: Diabetes mellitus (DM) negatively affects fracture repair by inhibiting endochondral ossification, chondrogenesis, callus formation, and angiogenesis. We previously reported that transcutaneous CO2 application accelerates fracture repair by promoting endochondral ossification and angiogenesis. The present study aimed to determine whether CO2 treatment would promote fracture repair in cases with type I DM. RESEARCH DESIGN AND METHODS: A closed femoral shaft fracture was induced in female rats with streptozotocin-induced type I DM. CO2 treatment was performed five times a week for the CO2 group. Sham treatment, where CO2 was replaced with air, was performed for the control group. Radiographic, histologic, genetic, and biomechanical measurements were taken at several time points. RESULTS: Radiographic assessment demonstrated that fracture repair was induced in the CO2 group. Histologically, accelerated endochondral ossification and capillary formation were observed in the CO2 group. Immunohistochemical assessment indicated that early postfracture proliferation of chondrocytes in callus was enhanced in the CO2 group. Genetic assessment results suggested that cartilage and bone formation, angiogenesis, and vasodilation were upregulated in the CO2 group. Biomechanical assessment revealed enhanced mechanical strength in the CO2 group. CONCLUSIONS: Our findings suggest that CO2 treatment accelerates fracture repair in type I DM rats. CO2 treatment could be an effective strategy for delayed fracture repair due to DM.Dec. 2020, BMJ open diabetes research & care, 8(2) (2), English, International magazineScientific journal
- IEEE, Nov. 2020, 2020 IEEE 50th International Symposium on Multiple-Valued Logic (ISMVL)International conference proceedings
- BACKGROUND: Carbon dioxide therapy has been reported to be effective in treating certain cardiac diseases and skin problems. Although a previous study suggested that transcutaneous carbon dioxide application accelerated fracture repair in association with promotion of angiogenesis, blood flow, and endochondral ossification, the influence of the duration of carbon dioxide application on fracture repair is unknown. The aim of this study was to investigate the effect of the duration of transcutaneous carbon dioxide application on rat fracture repair. METHODS: A closed femoral shaft fracture was created in each rat. Animals were randomly divided into four groups: the control group; 1w-CO2 group, postoperative carbon dioxide treatment for 1 week; 2w-CO2 group, postoperative carbon dioxide treatment for 2 weeks; 3w-CO2 group, postoperative carbon dioxide treatment for 3 weeks. Transcutaneous carbon dioxide application was performed five times a week in the carbon dioxide groups. Sham treatment, where the carbon dioxide was replaced with air, was performed for the control group. Radiographic, histological, and biomechanical assessments were performed at 3 weeks after fracture. RESULTS: The fracture union rate was significantly higher in the 3w-CO2 group than in the control group (p < 0.05). Histological assessment revealed promotion of endochondral ossification in the 3w-CO2 group than in the control group. In the biomechanical assessment, all evaluation items related to bone strength were significantly higher in the 3w-CO2 group than in the control group (p < 0.05). CONCLUSIONS: The present study, conducted using an animal model, demonstrated that continuous carbon dioxide application throughout the process of fracture repair was effective in enhancing fracture healing.Sep. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(5) (5), 886 - 891, English, Domestic magazine[Refereed]Scientific journal
- Aug. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 28(2) (2), 495 - 498, English, Domestic magazine
- Aug. 2020, Clinical Orthopaedics and Related Research, 478(8) (8), 1922 - 1935Scientific journal
- BACKGROUND: Distraction osteogenesis has been broadly used to treat various structural bone deformities and defects. However, prolonged healing time remains a major problem. Various approaches including the use of low-intensity pulsed ultrasound, parathyroid hormone, and bone morphogenetic proteins (BMPs) have been studied to shorten the treatment period with limited success. Our previous studies of rats have reported that the transcutaneous application of CO2 accelerates fracture repair and bone-defect healing in rats by promoting angiogenesis, blood flow, and endochondral ossification. This therapy may also accelerate bone generation during distraction osteogenesis, but, to our knowledge, no study investigating CO2 therapy on distraction osteogenesis has been reported. QUESTIONS/PURPOSES: We aimed to investigate the effect of transcutaneous CO2 during distraction osteogenesis in rabbits, which are the most suitable animal as a distraction osteogenesis model for a lengthener in terms of limb size. We asked: Does transcutaneous CO2 during distraction osteogenesis alter (1) radiographic bone density in the distraction gap during healing; (2) callus parameters, including callus bone mineral content, volumetric bone mineral density, and bone volume fraction; (3) the newly formed bone area, cartilage area, and angiogenesis, as well as the expression of interleukin-6 (IL-6), BMP-2, BMP-7, hypoxia-inducible factor (HIF) -1α, and vascular endothelial growth factor (VEGF); and (4) three-point bend biomechanical strength, stiffness, and energy? METHODS: Forty 24-week-old female New Zealand white rabbits were used according to a research protocol approved by our institutional ethical committee. A distraction osteogenesis rabbit tibia model was created as previously described. Briefly, an external lengthener was applied to the right tibia, and a transverse osteotomy was performed at the mid-shaft. The osteotomy stumps were connected by adjusting the fixator to make no gap. After a 7-day latency phase, distraction was continued at 1 mm per day for 10 days. Beginning the day after the osteotomy, a 20-minute transcutaneous application of CO2 on the operated leg using a CO2 absorption-enhancing hydrogel was performed five times per week in the CO2 group (n = 20). Sham treatment with air was administered in the control group (n = 20). Animals were euthanized immediately after the distraction period (n = 10), 2 weeks (n = 10), and 4 weeks (n = 20) after completion of distraction. We performed bone density quantification on the plain radiographs to evaluate consolidation in the distraction gap with image analyzing software. Callus parameters were measured with micro-CT to assess callus microstructure. The newly formed bone area and cartilage area were measured histologically with safranin O/fast green staining to assess the progress of ossification. We also performed immunohistochemical staining of endothelial cells with fluorescein-labeled isolectin B4 and examined capillary density to evaluate angiogenesis. Gene expressions in newly generated callus were analyzed by real-time polymerase chain reaction. Biomechanical strength, stiffness, and energy were determined from a three-point bend test to assess the mechanical strength of the callus. RESULTS: Radiographs showed higher pixel values in the distracted area in the CO2 group than the control group at Week 4 of the consolidation phase (0.98 ± 0.11 [95% confidence interval 0.89 to 1.06] versus 1.19 ± 0.23 [95% CI 1.05 to 1.34]; p = 0.013). Micro-CT demonstrated that bone volume fraction in the CO2 group was higher than that in the control group at Week 4 (5.56 ± 3.21 % [95% CI 4.32 to 6.12 %] versus 11.90 ± 3.33 % [95% CI 9.63 to 14.25 %]; p = 0.035). There were no differences in any other parameters (that is, callus bone mineral content at Weeks 2 and 4; volumetric bone mineral density at Weeks 2 and 4; bone volume fraction at Week 2). At Week 2, rabbits in the CO2 group had a larger cartilage area compared with those in the control group (2.09 ± 1.34 mm [95% CI 1.26 to 2.92 mm] versus 5.10 ± 3.91 mm [95% CI 2.68 to 7.52 mm]; p = 0.011). More newly formed bone was observed in the CO2 group than the control group at Week 4 (68.31 ± 16.32 mm [95% CI 58.19 to 78.44 mm] versus 96.26 ± 19.37 mm [95% CI 84.25 to 108.26 mm]; p < 0.001). There were no differences in any other parameters (cartilage area at Weeks 0 and 4; newly formed bone area at Weeks 0 and 2). Immunohistochemical isolectin B4 staining showed greater capillary densities in rabbits in the CO2 group than the control group in the distraction area at Week 0 and surrounding tissue at Weeks 0 and 2 (distraction area at Week 0, 286.54 ± 61.55 /mm [95% CI 232.58 to 340.49] versus 410.24 ± 55.29 /mm [95% CI 361.78 to 458.71]; p < 0.001; surrounding tissue at Week 0 395.09 ± 68.16/mm [95% CI 335.34 to 454.83] versus 589.75 ± 174.42/mm [95% CI 436.86 to 742.64]; p = 0.003; at Week 2 271.22 ± 169.42 /mm [95% CI 122.71 to 419.73] versus 508.46 ± 49.06/mm [95% CI 465.45 to 551.47]; p < 0.001 respectively). There was no difference in the distraction area at Week 2. The expressions of BMP -2 at Week 2, HIF1-α at Week 2 and VEGF at Week 0 and 2 were greater in the CO2 group than in the control group (BMP -2 at Week 2 3.84 ± 0.83 fold [95% CI 3.11 to 4.58] versus 7.32 ± 1.63 fold [95% CI 5.88 to 8.75]; p < 0.001; HIF1-α at Week 2, 10.49 ± 2.93 fold [95% CI 7.91 to 13.06] versus 20.74 ± 11.01 fold [95% CI 11.09 to 30.40]; p < 0.001; VEGF at Week 0 4.80 ± 1.56 fold [95% CI 3.43 to 6.18] versus 11.36 ± 4.82 fold [95% CI 7.13 to 15.59]; p < 0.001; at Week 2 31.52 ± 8.26 fold [95% CI 24.27 to 38.76] versus 51.05 ± 15.52 fold [95% CI 37.44 to 64.66]; p = 0.034, respectively). There were no differences in any other parameters (BMP-2 at Week 0 and 4; BMP -7 at Weeks 0, 2 and 4; HIF-1α at Weeks 0 and 4; IL-6 at Weeks 0, 2 and 4; VEGF at Week 4). In the biomechanical assessment, ultimate stress and failure energy were greater in the CO2 group than in the control group at Week 4 (ultimate stress 259.96 ± 74.33 N [95% CI 167.66 to 352.25] versus 422.45 ± 99.32 N [95% CI 299.13 to 545.77]; p < 0.001, failure energy 311.32 ± 99.01 Nmm [95% CI 188.37 to 434.25] versus 954.97 ± 484.39 Nmm [95% CI 353.51 to 1556.42]; p = 0.003, respectively). There was no difference in stiffness (216.77 ± 143.39 N/mm [95% CI 38.73 to 394.81] versus 223.68 ± 122.17 N/mm [95% CI 71.99 to 375.37]; p = 0.92). CONCLUSION: Transcutaneous application of CO2 accelerated bone generation in a distraction osteogenesis model of rabbit tibias. As demonstrated in previous studies, CO2 treatment might affect bone regeneration in distraction osteogenesis by promoting angiogenesis, blood flow, and endochondral ossification. CLINICAL RELEVANCE: The use of the transcutaneous application of CO2 may open new possibilities for shortening healing time in patients with distraction osteogenesis. However, a deeper insight into the mechanism of CO2 in the local tissue is required before it can be used in future clinical practice.Aug. 2020, Clinical orthopaedics and related research, 478(8) (8), 1922 - 1935, English, International magazineScientific journal
- Introduction: Subcapital fractures following internal fixation of an intertrochanteric fracture are relatively rare. It has been reported that these fractures are caused by improper placement of implants, osteoporosis, and any trauma episode. We report a rare case of subcapsular fracture possibly caused by whole femoral head necrosis following intertrochanteric fracture treatment. Case Report: An 88-year-old woman fell and sustained an intertrochanteric fracture of the left femur. She was treated with a short femoral nail (SFN) and 3 months after the surgery, bone union was observed. One year after the internal fixation of the intertrochanteric fracture, she complained of the left hip joint pain without any trauma, and the X-ray showed a subcapital fracture of the femur. She underwent nail removal and was treated with a bipolar hemiarthroplasty. Magnetic resonance imaging showed a change in the signal intensity of the entire head, and pathological findings revealed osteonecrosis. Normally, the reaction of bone resorption occurs below the necrosis area. We believe that the avascular necrosis (AVN) of the whole femoral head made the subcapital area fragile, resulting in a subcapital fracture. Conclusions: We should consider AVN of the whole femoral head as a potential cause of subcapital fracture after SFN fixation of intertrochanteric fractures.Jul. 2020, Journal of orthopaedic case reports, 10(4) (4), 42 - 44, English, International magazine
- BACKGROUND: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that regulate gene expression. There is increasing evidence that some miRNAs are involved in the pathology of diabetes mellitus (DM) and its complications. We hypothesized that the functions of certain miRNAs and the changes in their patterns of expression may contribute to the pathogenesis of impaired fractures due to DM. METHODS: In this study, 108 male Sprague-Dawley rats were divided into DM and control groups. DM rats were created by a single intravenous injection of streptozotocin. Closed transverse femoral shaft fractures were created in both groups. On post-fracture days 5, 7, 11, 14, 21, and 28, miRNA was extracted from the newly generated tissue at the fracture site. Microarray analysis was conducted with miRNA samples from each group on post-fracture days 5 and 11. The microarray findings were validated by real-time polymerase chain reaction (PCR) analysis at each time point. RESULTS: Microarray analysis revealed that, on days 5 and 11, 368 and 207 miRNAs, respectively, were upregulated in the DM group, compared with the control group. The top four miRNAs on day 5 were miR-339-3p, miR451-5p, miR-532-5p, and miR-551b-3p. The top four miRNAs on day 11 were miR-221-3p, miR376a-3p, miR-379-3p, and miR-379-5p. Among these miRNAs, miR-221-3p, miR-339-3p, miR-376a-3p, miR-379-5p, and miR-451-5p were validated by real-time PCR analysis. Furthermore, PCR analysis revealed that these five miRNAs were differentially expressed with dynamic expression patterns during fracture healing in the DM group, compared with the control group. CONCLUSIONS: Our findings will aid in understanding the pathology of impaired fracture healing in DM and may support the development of molecular therapies using miRNAs for the treatment of impaired fracture healing in patients with DM.Apr. 2020, Journal of orthopaedic surgery and research, 15(1) (1), 135 - 135, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Muscle atrophy causes difficulty in resuming daily activities after a fracture. Because transcutaneous carbon dioxide (CO2) application has previously upregulated oxygen pressure in the local tissue, thereby demonstrating its potential in preventing muscle atrophy, here we investigated effects of CO2 application on muscle atrophy after femoral shaft fracture. METHODS: Thirty fracture model rats were produced and randomly divided into a no treatment (control group) and treatment (CO2 group) groups. After treatment, the soleus muscle was dissected at post-fracture days 0, 14, and 21. Evaluations were performed by measuring muscle weight and performing histological examination and gene expression analysis. RESULTS: Muscle weight was significantly higher in the CO2 group than in the control group. Histological analysis revealed that the muscle fiber cross-sectional area was reduced in both groups. Nevertheless, the extent of atrophy was lesser in the CO2 group. Muscle fibers in the control group tended to change into fast muscle fibers. Vascular staining revealed that more capillary vessels surrounded the muscle fibers in the CO2 group than in the control group. Messenger RNA (mRNA) analysis revealed that the CO2 group had a significantly enhanced expression of genes that were related to muscle synthesis. CONCLUSION: Transcutaneous CO2 application may be a novel therapeutic strategy for preventing skeletal muscle atrophy after fracture.Mar. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(2) (2), 338 - 343, English, Domestic magazine[Refereed]Scientific journal
- Introduction: It remains controversial whether amputation or limb salvage is the best approach for mangled foot cases because there are no clear criteria for treatment. We report a case of successful limb salvage for a mangled foot, with good outcomes. Case Report: The patient was a 30-year-old man who sustained a crush injury to his left foot and ankle and lower legs in a car crash; he had severe open left foot and ankle fracture and bilateral open tibial shaft fractures. Blood flow was maintained by the posterior tibial artery, and the tibial nerve was intact. We stabilized the ankle using Kirschner wires on the day of injury. Plastic surgeons were consulted for early soft tissue coverage. Final fixation was performed 12 weeks after flap grafting; we grafted an autologous bone on the defect, according to the Masquelet technique. Four months after the final surgery, fullweightbearing gait was initiated. The patient is now capable of walking independently, with no pain, and is highly satisfied. Conclusions: Limb salvage can be successfully performed even in a patient with a severely mangled foot. For successful salvage surgery with good outcomes, such patients should be managed by a team of experienced orthopedic and plastic surgeons from an early stage to achieve appropriate bone alignment and soft tissue coverage.2020, Journal of orthopaedic case reports, 9(6) (6), 58 - 61, English, International magazine
- A 14-year-old girl experienced acute left buttock pain during a sprint. At the local hospital, she was diagnosed with an avulsion fracture of the left ischial tuberosity. She was kept for observation for about 10 months; however, the buttock pain persisted, and the bone fragments did not unite. She was referred to our hospital approximately 11 months after the injury. Plain radiography revealed an increased transposition of the bone fragment, from 12 mm immediately after the injury to 23 mm. Twelve months after the injury, she underwent osteosynthesis using two cannulated cancellous screws and three suture anchors. Following postoperative rehabilitation, the power in her left hamstring recovered, and she was able to run at full speed and returned to athletics 9 months after the surgery. The operative indications for avulsion fractures of the ischial tuberosity are unclear. Careful follow-up is required as the rate of nonunion after conservative treatment tends to be high. This needs to be identified in order to provide timely treatment that allows for early return to sport. Although she had significant chronic pain and muscle weakness, the surgery successfully treated the fracture, and her muscle power recovered, leading to her return to sports.2020, Case reports in orthopedics, 2020, 8531648 - 8531648, English, International magazine
- INTRODUCTION: Surgical site infection is one of the most severe complications of surgical treatments. However, the optimal procedure to prevent such infections remains uninvestigated. Ultraviolet radiation C (UVC) with a short wavelength has a high bactericidal effect; however, it is cytotoxic. Nonetheless, given that UVC with a wavelength of 222 nm reaches only the stratum corneum, it does not affect the skin cells. This study aimed to investigate the safety of 222-nm UVC irradiation and to examine its skin sterilization effect in healthy volunteers. METHODS: This trial was conducted on 20 healthy volunteers. The back of the subject was irradiated with 222-nm UVC at 50-500 mJ/cm2, and the induced erythema (redness of skin) was evaluated. Subsequently, the back was irradiated with a maximum amount of UVC not causing erythema, and the skin swabs before and after the irradiation were cultured. The number of colonies formed after 24 hours was measured. In addition, cyclobutene pyrimidine dimer (CPD) as an indicator of DNA damage was measured using skin tissues of the nonirradiated and irradiated regions. RESULTS: All subjects experienced no erythema at all doses. The back of the subject was irradiated at 500 mJ/cm2, and the number of bacterial colonies in the skin swab culture was significantly decreased by 222-nm UVC irradiation. The CPD amount produced in the irradiated region was slightly but significantly higher than that of the non-irradiated region. CONCLUSION: A 222-nm UVC at 500 mJ/cm2 was a safe irradiation dose and possessed bactericidal effects. In the future, 222-nm UVC irradiation is expected to contribute to the prevention of perioperative infection.2020, PloS one, 15(8) (8), e0235948, English, International magazineScientific journal
- BACKGROUND: Rad is the prototypic member of a subfamily of Ras-related small G-proteins and is highly expressed in the skeletal muscle of patients with type II diabetes. Our previous microarray analysis suggested that Rad may mediate fracture nonunion development. Thus, the present study used rat experimental models to investigate and compare the gene and protein expression patterns of both Rad and Rem1, another RGK subfamily member, in nonunions and standard healing fractures. METHODS: Standard healing fractures and nonunions (produced via periosteal cauterization at the fracture site) were created in the femurs of 3-month-old male Sprague-Dawley rats. At post-fracture days 7, 14, 21, and 28, the fracture callus and fibrous tissue from the standard healing fractures and nonunions, respectively, were harvested and screened (via real-time PCR) for Rad and Rem1 expression. The immunolocalization of both encoded proteins was analyzed at post-fracture days 14 and 21. At the same time points, hematoxylin and eosin staining was performed to identify the detailed tissue structures. RESULTS: Results of real-time PCR analysis showed that Rad expression increased significantly in the nonunions, compared to that in the standard healing fractures, at post-fracture days 14, 21, and 28. Conversely, immunohistochemical analysis revealed the immunolocalization of Rad to be similar to that of Rem1 in both fracture types at post-fracture days 14 and 21. CONCLUSIONS: Rad may mediate nonunion development, and thus, may be a promising therapeutic target to treat these injuries.Dec. 2019, BMC musculoskeletal disorders, 20(1) (1), 602 - 602, English, International magazine[Refereed]Scientific journal
- Introduction: We treated two cases of humeral shaft nonunion by minimally invasive plate osteosynthesis (MIPO) without autogenous bone grafting. Presntation of case: Case 1: An osteosynthesis with intramedullary nailing (IMN) was performed on a 17-year-old female for a humeral shaft fracture at another hospital; however, bony union was not obtained. We removed the nail and screws, then performed MIPO without autogenous bone grafting. At the final follow-up of 4 years after the surgery, she had obtained full range of motion.Case 2: Osteosynthesis with Rush pins had been performed in a 73-year-old female for a humeral shaft fracture at another hospital. Five months later, a revision surgery using IMN was performed at the same hospital; however, this led to nonunion. We removed the IMN and performed MIPO without autogenous bone grafting. At the final follow-up 2 years after surgery, she had obtained full range of motion. Discussion: The cause of nonunion is the lack of mechanical instability and/or biological activity. In these cases, from the findings of radiography and bone scintigraphy, mechanical instability was thought to be the primary cause; therefore, in order to enhance stability, we used a locking plate. Because we can see that these cases are biologically active, we decided not to use bone grafting. Both our cases successfully achieved bony union and excellent functional recovery using this method. Conclusion: We performed MIPO without exposure of the nonunion site and autogenous bone grafting in two cases of humeral shaft nonunion, and obtained successful clinical outcomes.Dec. 2019, Annals of medicine and surgery (2012), 48, 43 - 47, English, International magazine[Refereed]
- BACKGROUND: Clinicians have very limited options to improve fracture repair. Therefore, it is critical to develop a new clinically available therapeutic option to assist fracture repair biologically. We previously reported that the topical cutaneous application of carbon dioxide (CO2) via a CO2 absorption-enhancing hydrogel accelerates fracture repair in rats by increasing blood flow and angiogenesis and promoting endochondral ossification. The aim of this study was to assess the safety and efficacy of CO2 therapy in patients with fractures. METHODS: Patients with fractures of the femur and tibia were prospectively enrolled into this study with ethical approval and informed consent. The CO2 absorption-enhancing hydrogel was applied to the fractured lower limbs of patients, and then 100% CO2 was administered daily into a sealed space for 20 min over 4 weeks postoperatively. Safety was assessed based on vital signs, blood parameters, adverse events, and arterial and expired gas analyses. As the efficacy outcome, blood flow at the level of the fracture site and at a site 5 cm from the fracture in the affected limb was measured using a laser Doppler blood flow meter. RESULTS: Nineteen patients were subjected to complete analysis. No adverse events were observed. Arterial and expired gas analyses revealed no adverse systemic effects including hypercapnia. The mean ratio of blood flow 20 min after CO2 therapy compared with the pre-treatment level increased by approximately 2-fold in a time-dependent manner. CONCLUSIONS: The findings of the present study revealed that CO2 therapy is safe to apply to human patients and that it can enhance blood flow in the fractured limbs. TRIAL REGISTRATION: This study has been registered in the UMIN Clinical Trials Registry (Registration number: UMIN000013641, Date of registration: July 1, 2014).Nov. 2019, BMC musculoskeletal disorders, 20(1) (1), 563 - 563, English, International magazine[Refereed]Scientific journal
- Institute of Electrical and Electronics Engineers Inc., Nov. 2019, 2019 IEEE International Conference on Electrical, Control and Instrumentation Engineering, ICECIE 2019 - Proceedings, EnglishInternational conference proceedings
- Sep. 2019, Journal of orthopaedic surgery (Hong Kong), 27(3) (3), 2309499019877517, English[Refereed]Scientific journal
- Introduction: Medial clavicle fractures are rare injuries. Symptomatic nonunion arises up to 8% of medial clavicle fractures when treated conservatively. Presentation of case: A 53-year-old man sustained a left medial clavicle fracture and was treated conservatively at another hospital. Nine months after his initial injury, he was referred to our institution. We diagnosed pseudarthrosis of the medial clavicle. We performed open reduction and internal fixation using an inverted distal clavicle locking plate. At the 1-year follow-up, radiographs showed bone union. Discussion: This is the first reported case of medial clavicle pseudarthrosis treated with an inverted distal clavicle anatomical locking plate. There are several advantages in using this plate. Conclusion: This method is a good treatment option.Aug. 2019, Annals of medicine and surgery (2012), 44, 1 - 4, English, International magazine[Refereed]
- BACKGROUND: Bone defects may occur because of severe trauma, nonunion, infection, or tumor resection. However, treatments for bone defects are often difficult and have not been fully established yet. We previously designed an efficient system of topical cutaneous application of carbon dioxide (CO2) using a novel hydrogel, which facilitates CO2 absorption through the skin into the deep area within a limb. In this study, the effect of topical cutaneous application of CO2 on bone healing was investigated using a rat femoral defect model. METHODS: In this basic research study, an in vivo bone defect model, fixed with an external fixator, was created using a rat femur. The affected limb was shaved, and CO2 was applied for 20 min/day, 5 days/week. In the control animals, CO2 gas was replaced with air. Radiographic, histological, biomechanical, and genetic assessments were performed to evaluate bone healing. RESULTS: Radiographically, bone healing rate was significantly higher in the CO2 group than in the control group at 4 weeks (18.2% vs. 72.7%). The degree of bone healing scored using the histopathological Allen grading system was significantly higher in the CO2 group than in the control group at 2 weeks (1.389 ± 0.334 vs. 1.944 ± 0.375). The ultimate stress, extrinsic stiffness, and failure energy were significantly greater in the CO2 group than in the control group at 4 weeks (3.2 ± 0.8% vs. 38.1 ± 4.8%, 0.6 ± 0.3% vs. 41.5 ± 12.2%, 2.6 ± 0.8% vs. 24.7 ± 5.9%, respectively.). The volumetric bone mineral density of the callus in micro-computed tomography analysis was significantly higher in the CO2 group than in the control group at 4 weeks (180.9 ± 43.0 mg/cm3 vs. 247.9 ± 49.9 mg/cm3). Gene expression of vascular endothelial growth factor in the CO2 group was significantly greater than that in the control group at 3 weeks (0.617 ± 0.240 vs. 2.213 ± 0.387). CONCLUSIONS: Topical cutaneous application of CO2 accelerated bone healing in a rat femoral defect model. CO2 application can be a novel and useful therapy for accelerating bone healing in bone defects; further research on its efficacy in humans is warranted.May 2019, BMC musculoskeletal disorders, 20(1) (1), 237 - 237, English, International magazine[Refereed]Scientific journal
- PURPOSE: This study investigated whether Escherichia coli-derived bone morphogenetic protein (BMP)-2 (E-BMP-2) adsorbed onto β-tricalcium phosphate (β-TCP) granules can induce bone regeneration in critical-size femoral segmental defects in rabbits. METHODS: Bone defects 20 mm in size and stabilized with an external fixator were created in the femur of New Zealand white rabbits, which were divided into BMP-2 and control groups. E-BMP-2-loaded β-TCP granules were implanted into defects of the BMP-2 group, whereas defects in the controls were implanted with β-TCP granules alone. At 12 and 24 weeks after surgery, radiographs were obtained of the femurs and histological and biomechanical assessments of the defect area were performed. Bone regeneration was quantified using micro-computed tomography at 24 weeks. RESULTS: Radiographic and histologic analyses revealed bone regeneration in the BMP-2 group but not the control group; no fracturing of newly formed bone occurred when the external fixator was removed at 12 weeks. At 24 weeks, tissue mineral density, the ratio of bone volume to total volume, and volumetric bone mineral density of the callus were higher in the BMP-2 group than in control animals. In the former, ultimate stress, extrinsic stiffness, and failure energy measurements for the femurs were higher at 24 weeks than at 12 weeks. CONCLUSION: E-BMP-2-loaded β-TCP granules can effectively promote bone regeneration in long bone defects.May 2019, International orthopaedics, 43(5) (5), 1247 - 1253, English, International magazine[Refereed]Scientific journal
- Although the definition of atypical femoral fracture (AFF) excludes periprosthetic femoral fracture (PFF), the number of reports about PFF with characteristics of AFF is increasing. We present the case of such a fracture in this report. An 87-year-old woman who underwent bipolar hip arthroplasty for a femoral neck fracture 38 months prior reported left thigh pain with no history of trauma. Radiographs showed a simple transverse fracture at the level of the stem distal end with features of AFF: periosteal thickening of the lateral cortex, a medial spike, and a noncomminuted fracture. She presented other features resembling AFF: history of bisphosphonate use, prodromal symptoms, no associated trauma, and lateral bowing of the contralateral femur. The fracture showed nonunion after the initial osteosynthesis, and a revision surgery of the arthroplasty and osteosynthesis was performed. Nine months after the surgery, bony union was achieved and she regained the ability to walk. It is supposed that the fracture was influenced by a stress force related to implants and lateral bowing concentrating on the fracture site as a mechanical factor in addition to bisphosphonates as a biological factor. It would be important to recognize that AFF could occur at the peri-implant location, and early detection and treatment are essential.2019, Case reports in orthopedics, 2019, 1275369 - 1275369, English, International magazine[Refereed]
- Introduction: Osteogenesis imperfecta (OI) is a heritable disorder of connective tissue. Due to poor bone quality, patients with OI develop bone fracture and subsequent non-union at high rates. We report the rare case of humeral shaft non-union successfully treated by a locking plate used formandibular bone in a patient with OI. Case Report: A 26-year-old man with Type III OI and a history of corrective osteotomy with Kirschner wire fixation of his right humerus at the age of 8 years developed gradually increasing pain in his humerus. He sustained humeral shaft non-union due to a broken Kirschner wire used in the previous operation and was referred to our hospital. He underwent internal fixation using an elastic nail with an iliac bone graft. However, 2 years after the operation, bony union was not achieved due to elastic nail breakage, and he complained of pain and activity limitation. He underwent re-operation for the humeral non-union using a locking plate to achieve rigid fixation. Because his humeral shaft was extremely narrow with severe deformity, we used a locking plate for the mandibular bone, which was contoured to fit the medial side of the humeral shaft. Bony union was achieved, the pain was relieved, and the patient returned to his pre-injury activity with no symptoms.4years after the operation, a new fracture line was found in radiographs of the distal part of the non-union. Bony union was achieved by conservative treatment. At present, the function has recovered. Conclusion: Humeral non-union in this patient with OI was successfully treated by a mandible locking plate. Although the optimal fixation device for fractures or non-unions in patients with OI has not yet been established, this plate could be a good treatment option for narrow and severely deformed bone.2019, Journal of orthopaedic case reports, 9(3) (3), 19 - 21, English, International magazine[Refereed]
- Springer Tokyo, Jul. 2018, The journal of physiological sciences : JPS, 68(4) (4), 463 - 470, English, Domestic magazine[Refereed]Scientific journal
- May 2018, Journal of Advanced Computational Intelligence and Intelligent Informatics, 22(3) (3), 333 - 340, English[Refereed]Scientific journal
- British Editorial Society of Bone and Joint Surgery, Feb. 2018, Bone and Joint Research, 7(2) (2), 139 - 147, English[Refereed]Scientific journal
- Rotational malreduction is a potential complication of intramedullary nailing for tibial shaft fractures. We experienced a symptomatic case of a 24° externally rotated malunion that we treated with minimally invasive corrective osteotomy. A 49-year-old man sustained a tibial shaft spiral fracture with a fibula fracture. He had been initially treated elsewhere with a reamed statically locked intramedullary nail. Bone union had been obtained, but he complained of asymmetry of his legs, difficulty walking and running, and the inability to ride a bicycle. We decided to perform corrective osteotomy in a minimally invasive fashion. After a 1 cm incision was made at the original fracture site, osteotomy for the affected tibia was performed with an osteotome after multiple efforts at drilling around the nail with the aim of retaining it. Fibula osteotomy was also performed at the same level. Two Kirschner wires that created an affected rotational angle between the fragments were inserted as a guide for correction. The distal locking screws were removed. Correct rotation was regained by matching the two wires in a straight line. Finally, the distal locking screws were inserted into new holes. The patient obtained bony union and has returned to his preinjury activities with no symptoms.2018, Case reports in orthopedics, 2018, 4190670 - 4190670, English, International magazine[Refereed]
- INTRODUCTION: Osteopetrosis is a skeletal disorder characterized by increased osteodensity and a remodeling defect. The fragility of dense sclerotic bones may lead to an increased incidence of fractures. Although internal fixation can be performed, technical challenges may be experienced because of the increased bone density. Complications such as delayed union, nonunion, or implant failure may occur postoperatively. PRESENTATION OF CASE: We describe a patient with autosomal-dominant osteopetrosis type 2 who suffered a shaft fracture below a plate of his right femur. We performed osteosynthesis with a single locking plate. Union was delayed, and plate breakage occurred along with nonunion of the fracture. The nonunion was addressed using double locking plates, which secured fixation and allowed complete fracture healing. DISCUSSION: There were three reasons of nonunion in our case. First, we left gaps between the fragments. Second, we used mainly cerclage wires, rather than screws, for plate fixation, which led to inadequate stability. Third, the patient was large (height 167 cm, weight 93.1 kg), so the single plate provided insufficient fixing force. We then used double locking plates and attained stronger internal fixation with complete fracture healing. CONCLUSION: Double plating with locking plates may be an effective treatment option for femoral fractures in patients with osteopetrosis.2018, International journal of surgery case reports, 51, 395 - 399, English, International magazine[Refereed]Scientific journal
- INTRODUCTION: Heterotopic ossification is a major complication after surgical treatment of acetabular fractures. Heterotopic ossification generally involves the large joints, often limits the range of motion, and may cause ankylosis. PRESENTATION OF CASE: This case report describes a 59-year-old man with severe heterotopic ossification who developed an acetabular fracture and resultant hip ankylosis, which was rescued by surgical resection of the heterotopic ossification. He had accompanying head injury and multiple other fractures, which were treated conservatively. Open reduction with internal fixation of the acetabular fracture was performed through the ilioinguinal and Kocher-Langenbeck combined approach. The patient unexpectedly returned to our hospital 7.5 months after the fracture surgery. We found that his left hip joint was completely ankylosed by severe heterotopic ossification. We performed surgical resection of the heterotopic ossification through a direct lateral approach 9.5 months after the initial surgery. At the final follow-up, 5.5 years after the heterotopic ossification resection surgery, the hip function including the range of motion was satisfactory. Radiographs showed no signs of recurrence, and he could walk with no support. DISCUSSION: The only effective treatment for established HO is surgical excision. Whether delayed or early surgical resection of heterotopic ossification is more effective remains controversial. CONCLUSION: We considered that waiting for a long time before surgical resection of the heterotopic ossification would lead to more disability, and early resection of the heterotopic ossification was not a contraindication despite the fact that the uptake on the bone scan was still intense.2018, International journal of surgery case reports, 53, 107 - 111, English, International magazine[Refereed]Scientific journal
- SAGE Publications Ltd, Jan. 2017, Journal of orthopaedic surgery (Hong Kong), 25(1) (1), 2309499017692700 - 2309499017692700, English, International magazine[Refereed]Scientific journal
- Feb. 2016, BMC musculoskeletal disorders, 17, 83 - 83, English, International magazine[Refereed]Scientific journal
- 2016, 2016 JOINT 8TH INTERNATIONAL CONFERENCE ON SOFT COMPUTING AND INTELLIGENT SYSTEMS (SCIS) AND 17TH INTERNATIONAL SYMPOSIUM ON ADVANCED INTELLIGENT SYSTEMS (ISIS), 822 - 826, English[Refereed]International conference proceedings
- Nov. 2014, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 19(6) (6), 984 - 90, English, Domestic magazine[Refereed]Scientific journal
- A Morel-Lavallee lesion (MLL) involves posttraumatic fluid collection around the greater trochanter. Many cases of MLL are missed at the initial evaluation, and the treatment of MLL is not well established. We present two cases in which MLL was missed at the initial evaluation. Case 1. A 65-year-old man was run over by a parade float. There was subcutaneous hematoma around the left greater trochanter, and no fracture was found. We diagnosed this injury as MLL on the 7th day after the trauma. Although we performed percutaneous drainage, the injured area was infected. Case 2. A 57-year-old man was hit by a train in a factory. There was an iliac wing fracture, but an MLL was not initially recognized. On the 6th day after the trauma, when performing open reduction and internal fixation for the iliac fracture, we recognized the lesion and performed percutaneous drainage simultaneously. This lesion also became infected. In these two cases, the wounds finally healed after a long duration of treatment. We suggest that it is important to keep this injury in mind and debride the lesion early and completely in the treatment course.2014, Case reports in orthopedics, 2014, 920317 - 920317, English, International magazine[Refereed]Scientific journal
- Jun. 2013, Journal of tissue engineering and regenerative medicine, 7(6) (6), 501 - 4, English, International magazine[Refereed]Scientific journal
- Jan. 2013, Journal of orthopaedic trauma, 27(1) (1), 29 - 33, English, International magazine[Refereed]Scientific journal
- Patients with Werner's syndrome frequently develop chronic leg ulcers that heal poorly. We present a patient who suffered from this rare syndrome and developed typical heel ulcers. Treatment of the ulcer is challenging, as flap options are limited over the lower third of the leg and skin grafting is not easy as there is a lack of healthy granulations. We successfully treated the ulcer with osteomyelitis by drilling the bone and applying an ultrathin split thickness skin graft with the thigh skin as the donor site.2013, Case reports in orthopedics, 2013, 287025 - 287025, English, International magazine[Refereed]Scientific journal
- Oct. 2012, Orthopedics, 35(10) (10), e1476-82 - E1482, English, International magazine[Refereed]Scientific journal
- Aug. 2012, Journal of orthopaedic surgery (Hong Kong), 20(2) (2), 196 - 200, English, International magazine[Refereed]Scientific journal
- Jun. 2012, Orthopedics, 35(6) (6), 491 - 5, English, International magazine[Refereed]Scientific journal
- May 2012, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 17(3) (3), 233 - 8, English, Domestic magazine[Refereed]Scientific journal
- Mar. 2012, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 70(3) (3), 599 - 607, English, International magazine[Refereed]Scientific journal
- Feb. 2012, The journal of trauma and acute care surgery, 72(2) (2), E1-E7 - E7, English, International magazine[Refereed]Scientific journal
- 2012, 2012 IEEE INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS (FUZZ-IEEE), 1 - 6, English[Refereed]International conference proceedings
- Dec. 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 29(12) (12), 1820 - 6, English, International magazine[Refereed]Scientific journal
- Jun. 2011, Orthopedics, 34(6) (6), 211 - 211, English, International magazine[Refereed]Scientific journal
- Apr. 2011, Biochemical and biophysical research communications, 407(1) (1), 148 - 52, English, International magazine[Refereed]Scientific journal
- 2011, Cell transplantation, 20(9) (9), 1491 - 6, English, International magazine[Refereed]Scientific journal
- 2011, PloS one, 6(9) (9), e24137, English, International magazine[Refereed]Scientific journal
- Jan. 2011, Nihon rinsho. Japanese journal of clinical medicine, 69 Suppl 1, 406 - 9, Japanese, Domestic magazine[Nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD)].Scientific journal
- Aug. 2010, JOURNAL OF DENTAL RESEARCH, 89(8) (8), 854 - 859, English[Refereed]Scientific journal
- Jun. 2010, Tissue engineering. Part C, Methods, 16(3) (3), 347 - 53, English, International magazine[Refereed]Scientific journal
- 2010, 2010 IEEE INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS (FUZZ-IEEE 2010), 1 - 6, English[Refereed]International conference proceedings
- Nov. 2009, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 17(11) (11), 1336 - 9, English, International magazine[Refereed]Scientific journal
- Aug. 2009, Orthopedics, 32(8) (8), 611, English, International magazine[Refereed]Scientific journal
- Apr. 2009, European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 18(4) (4), 570 - 6, English, International magazine[Refereed]Scientific journal
- Feb. 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 27(2) (2), 208 - 15, English, International magazine[Refereed]Scientific journal
- Feb. 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 26(2) (2), 190 - 9, English, International magazine[Refereed]Scientific journal
- 2008, 2008 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN AND CYBERNETICS (SMC), VOLS 1-6, 3061 - +, English[Refereed]International conference proceedings
- 2007, GRC: 2007 IEEE INTERNATIONAL CONFERENCE ON GRANULAR COMPUTING, PROCEEDINGS, 636 - +, English[Refereed]International conference proceedings
- 2007, 2007 IEEE/ICME INTERNATIONAL CONFERENCE ON COMPLEX MEDICAL ENGINEERING, VOLS 1-4, 426 - 429, English[Refereed]International conference proceedings
- Jan. 2007, JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 89B(1) (1), 133 - 138, English[Refereed]Scientific journal
- (株)メディカ出版, Jun. 2024, 整形外科看護, (2024夏季増刊) (2024夏季増刊), 76 - 81, Japanese【外傷・治療・看護の必須観察ポイント「超」まるごと骨折 これ一冊】(第3章)上肢の骨折 上腕骨骨幹部骨折
- (公社)日本整形外科学会, Apr. 2023, 日本整形外科学会雑誌, 97(4) (4), 252 - 260, Japanese
- (株)全日本病院出版会, Aug. 2022, Orthopaedics, 35(8) (8), 61 - 71, Japanese
- (一社)日本骨折治療学会, Jun. 2022, 骨折, 44(Suppl.) (Suppl.), S68 - S68, Japanese
- (一社)日本骨折治療学会, Jun. 2022, 骨折, 44(Suppl.) (Suppl.), S217 - S217, Japanese
- (一社)日本骨折治療学会, Jun. 2022, 骨折, 44(Suppl.) (Suppl.), S268 - S268, Japanese
- 日本四肢再建・創外固定学会, Apr. 2022, 日本四肢再建・創外固定学会雑誌, 33, 161 - 161, Japanese創外固定治療とMasquelet法のコラボレーション
- (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S878 - S878, Japanese
- (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S1027 - S1027, Japanese
- 2022, 糖尿病(Web), 65(Suppl) (Suppl)KLF15を介した筋萎縮の分子機構の解明
- (一社)日本核医学会, Oct. 2021, 核医学, 58(Suppl.) (Suppl.), S198 - S198, English非感染性偽関節に対する骨SPECTの定量評価(Quantitative evaluation of bone SPECT for uninfected nonunion)
- (一社)日本環境感染学会, Sep. 2021, 日本環境感染学会総会プログラム・抄録集, 36回, 204 - 204, Japanese222nm UVCのヒトに対する安全性と有効性
- (一社)日本骨粗鬆症学会, Sep. 2021, 日本骨粗鬆症学会雑誌, 7(Suppl.1) (Suppl.1), 165 - 165, Japanese糖尿病性骨症の病態と臨床疫学 整形外科から見た糖尿病患者の骨折とそのマネジメント
- (一社)中部日本整形外科災害外科学会, Sep. 2021, 中部日本整形外科災害外科学会雑誌, 64(秋季学会) (秋季学会), 215 - 215, JapaneseKlippel-Trenaunay症候群の患者に生じた大腿骨感染性偽関節に対する治療経験
- (一社)日本環境感染学会, Sep. 2021, 日本環境感染学会総会プログラム・抄録集, 36回, 204 - 204, Japanese222nm UVCのヒトに対する安全性と有効性
- (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1464 - S1464, Japanese
- (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1465 - S1465, Japanese
- (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1689 - S1689, Japanese
- (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1464 - S1464, Japanese偽関節、感染性偽関節の基礎研究と臨床応用 偽関節患者への自家末梢血CD34陽性細胞移植
- (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1465 - S1465, Japanese偽関節、感染性偽関節の基礎研究と臨床応用 Masquelet法の根幹をなすinduced membraneについての組織学的研究
- (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1689 - S1689, Japaneseヒトinduced membraneにおけるbone morphogenetic proteins(BMP)発現の検討
- (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1814 - S1814, JapaneseNon-hypertrophic nonunion cellsの増殖能・骨分化能に対するE-BMP-2の効果の検討
- (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S13 - S13, Japanese
- (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S30 - S30, Japanese
- (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S40 - S40, Japanese
- (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S41 - S41, Japanese
- (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S170 - S170, Japanese
- (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S198 - S198, Japanese
- (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S141 - S141, Japanese
- (一社)日本理学療法学会連合, Mar. 2021, 理学療法学, 47(Suppl.1) (Suppl.1), 159 - 159, Japanese体外衝撃波療法は閉経後の骨粗鬆症を改善する
- (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S152 - S152, Japanese
- (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S153 - S153, Japanese
- (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S644 - S644, Japanese
- (株)医学書院, Mar. 2021, 臨床整形外科, 56(3) (3), 241 - 245, Japanese
- (株)医学書院, Mar. 2021, 臨床整形外科, 56(3) (3), 261 - 266, Japanese
- (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S152 - S152, Japanese
- (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S153 - S153, Japanese
- (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S644 - S644, Japanese
- 金原出版(株), Feb. 2021, 整形・災害外科, 64(2) (2), 231 - 234, JapaneseFracture of the lateral process of the talus and peroneal tendon dislocation with lateral malleolar avulsion fracture
- (株)メディカルレビュー社, Feb. 2021, 再生医療, 20(1) (1), 50 - 55, JapaneseClinically applicable regeneration therapy: Transplantation of autologous peripheral blood CD34-positive cells to fracture nonunion patients
- 2021, 核医学(Web), 58(Supplement) (Supplement)Quantitative evaluation of bone SPECT for uninfected nonunion
- (一社)日本骨折治療学会, Jan. 2021, 骨折, 43(1) (1), 41 - 44, Japanese
- 2021, 骨折(Web), 43(1) (1)Intra-medullary nail motion in the fixation for trochanteric femoral fracture with short femoral nail-Biomechanical analysis in sawbones-
- (一社)中部日本整形外科災害外科学会, Jan. 2021, 中部日本整形外科災害外科学会雑誌, 64(1) (1), 73 - 74, JapaneseThe treatment of metastatic bone tumor of the acetabulum with bone cement and screw fixation: case report
- (一社)中部日本整形外科災害外科学会, 2021, 中部日本整形外科災害外科学会雑誌, 64(春季学会) (春季学会), 15 - 15, Japanese偽関節-どうしてこうなったか,なったらどうするか-
- (一社)中部日本整形外科災害外科学会, 2021, 中部日本整形外科災害外科学会雑誌, 64(春季学会) (春季学会), 135 - 135, Japanese膀胱癌手術後に両下腿のwell leg compartment syndrome(WLCS)を生じた一例
- 金原出版(株), Jan. 2021, 整形・災害外科, 64(1) (1), 61 - 69, JapaneseLow-intensity pulsed ultrasound treatment for fracture nonunion
- (一社)日本骨折治療学会, Jan. 2021, 骨折, 43(1) (1), 41 - 44, Japanese
- (株)医学書院, 2021, 臨床整形外科, 56(3) (3), 241 - 245, JapaneseRegeneration Therapy to Treat Fracture Nonunion: Transplantation of Autologous Peripheral Blood CD34-Positive Cells
- (株)医学書院, 2021, 臨床整形外科, 56(3) (3), 261 - 266, JapaneseTargeting of the Low-intensity Pulsed Ultrasound Application for an Effective Use
- 日本筋学会, Dec. 2020, 日本筋学会学術集会プログラム・抄録集, 6回, 46 - 46, Japanese不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する
- (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 95 - 95, Japanese寛骨臼の転移性骨腫瘍に対して骨セメント充填及びスクリューによる内固定を行った2例
- (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 157 - 157, Japanese上腕骨インプラント周囲骨折後にballooning変形を起こした偽関節の1例
- (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S36 - S36, Japanese
- (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S40 - S40, Japanese
- (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S70 - S70, Japanese
- (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S121 - S121, Japanese
- (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S121 - S121, Japanese
- (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S122 - S122, Japanese
- (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S129 - S129, Japanese
- (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S146 - S146, Japanese
- (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S366 - S366, Japanese
- (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1684 - S1684, Japanese卵巣摘出ラット骨粗鬆症モデルにおける炭酸ガス経皮吸収による骨粗鬆症改善効果の検討
- (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1685 - S1685, JapaneseReamer irrigator aspirator(RIA)産物から得た細胞の骨分化に対するlow-intensity pulsed ultrasound(LIPUS)の効果
- (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1713 - S1713, Japaneseウサギを用いた222nm紫外線術野照射の安全性の検討
- (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1802 - S1802, Japanese炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおける骨折治癒を促進させる
- (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1918 - S1918, Japanese骨折治癒過程を超音波の周波数特性により推定する試み
- (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1956 - S1956, Japanese男性骨粗鬆症モデルラットに対する炭酸ガス経皮吸収の影響に関する検討
- (一社)日本内分泌学会, Aug. 2020, 日本内分泌学会雑誌, 96(1) (1), 248 - 248, Japanese不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する
- (一社)日本糖尿病学会, Aug. 2020, 糖尿病, 63(Suppl.1) (Suppl.1), S - 238, Japanese不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する
- 日本臨床分子医学会, Apr. 2020, 日本臨床分子医学会学術総会プログラム・抄録集, 57回, 58 - 58, Japanese不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する
- (株)メジカルビュー社, Apr. 2020, 関節外科, 39(4月増刊) (4月増刊), 145 - 150, JapaneseBasic research for acceleration of fracture repair to translate to clinical application
- (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 271 - 271, Japanese髄内釘のコンプレッション機構を利用し、自家骨移植なしで治療した上腕骨骨幹部偽関節の一例
- 日本CAOS研究会・日本最小侵襲整形外科学会, Mar. 2020, 日本CAOS研究会・日本最小侵襲整形外科学会プログラム・抄録集, 14回・26回, 72 - 72, Japanese外傷診療におけるCAOSの応用 難治骨折治療における3D実寸大骨モデルの応用
- (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1040 - S1040, Japanese
- 日本創外固定・骨延長学会, Mar. 2020, 日本創外固定・骨延長学会雑誌, 31, 352 - 352, JapaneseThe effect of transcutaneous CO2 application on distraction osteogenesis of rabbit tibia
- (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(2) (2), S160 - S160, Japanese健常人における222 nmUVC照射の安全性と殺菌効果の検討
- (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S949 - S949, Japanese日本人におけるreamer irrigator aspirator(RIA)の使用経験とRIAリーマー径についての検討
- (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S579 - S579, JapaneseDBMを利用した骨欠損や偽関節の治療
- (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S904 - S904, Japanese大腿骨頸部骨折の術後CT画像評価方法の検討
- (一社)日本骨折治療学会, Jan. 2020, 骨折, 42(1) (1), 1 - 5, Japanese
- 2020, 骨折(Web), 42(1) (1)Intra-medullary distribution of antibiotics by intra-medullary antibiotics perfusion(iMAP)-A cadaver study-
- 2020, 骨折(Web), 42(Supplement) (Supplement)Intra-medullary nail motion in the fixation for trochanteric femoral fracture with short femoral nail; Biomechanical analysis in Sawbones.
- 2020, 骨折(Web), 42(Supplement) (Supplement)Targeting of low-intensity pulsed ultrasound treatment
- 2020, 骨折(Web), 42(Supplement) (Supplement)Histological analysis of the induced membrane of the patients whose bone defects were treated by the Masquelet technique
- 2020, 骨折(Web), 42(Supplement) (Supplement)Multicenter study on atypical femoral fractures in patients with bone metastases using bone modifying agents
- 2020, 骨折(Web), 42(Supplement) (Supplement)Investigation of the effect of topical cutaneous CO2 application on fracture healing in streptozotocin-induced diabetic rats
- 2020, 骨折(Web), 42(Supplement) (Supplement)Assessment of induced membrane formation by magnetic resonance imaging in Masquelet reconstruction surgery
- 2020, 骨折(Web), 42(Supplement) (Supplement)Cell therapy for patients with femoral and tibial Nonunion
- 2020, 骨折(Web), 42(Supplement) (Supplement)Quantitative Bone SPECT imaging for non union
- 2020, 骨折(Web), 42(Supplement) (Supplement)Is the Masquelet induced membrane a pseudo-synovial membrane?
- 2020, 超音波骨折治療研究会プログラム・抄録集, 23rdReamer irrigator aspirator(RIA)産物から得た細胞の骨分化に対するlow-intensity pulsed ultrasound(LIPUS)の効果
- 2020, 電気関係学会関西連合大会(Web), 2020超音波画像を用いた骨癒合の評価
- (一社)日本肥満学会, Oct. 2019, 肥満研究, 25(Suppl.) (Suppl.), 260 - 260, Japanese
- (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(秋季学会) (秋季学会), 109 - 109, Japanese自己免疫性多内分泌腺症候群2型による続発性骨軟化症にて両側脛骨近位端骨折を生じた1例
- (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1622 - S1622, Japanese
- (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1755 - S1755, Japanese
- (一社)日本骨粗鬆症学会, Sep. 2019, 日本骨粗鬆症学会雑誌, 5(Suppl.1) (Suppl.1), 457 - 457, Japanese非定型大腿骨骨折術後偽関節の治療経験
- (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(5) (5), 958 - 958, Japanese腫瘍性骨軟化症による大腿骨頸部病的骨折をきたした1例
- (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1749 - S1749, Japanese骨格筋量制御におけるKLF15の機能の解析
- (株)メディカ出版, Aug. 2019, 整形外科Surgical Technique, 9(4) (4), 430 - 437, Japanese
- (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S101 - S101, Japanese
- (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S167 - S167, Japanese
- (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S170 - S170, Japanese
- (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S378 - S378, Japanese
- (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S420 - S420, Japanese
- 日本臨床分子医学会, Apr. 2019, 日本臨床分子医学会学術総会プログラム・抄録集, 56回, 71 - 71, Japanese骨格筋量制御におけるKLF15の機能の解析
- (一社)日本糖尿病学会, Apr. 2019, 糖尿病, 62(Suppl.1) (Suppl.1), S - 149, Japanese骨格筋量制御におけるKLF15の機能の解析
- (一社)日本糖尿病学会, Apr. 2019, 糖尿病, 62(Suppl.1) (Suppl.1), S - 149, Japanese骨格筋量制御におけるKLF15の機能の解析
- (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S113 - S113, Japanese
- (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(春季学会) (春季学会), 200 - 200, Japanese坐骨結節裂離骨折偽関節に対し手術加療を行った1例
- (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(3) (3), S963 - S963, Japanese患者立脚型機能評価による大腿骨・脛骨偽関節の治療成績の検討
- (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(3) (3), S965 - S965, JapaneseReamer irrigator aspirator(RIA)を日本人患者に使用した臨床経験
- 2019, 移植(Web), 54(4-5) (4-5)ウサギ骨延長術モデルにおける炭酸ガス経皮吸収の骨形成促進効果について
- 2019, 骨折(Web), 41(Supplement) (Supplement)Surgical treatment with locking plate for lower limb nonunion
- 2019, 骨折(Web), 41(Supplement) (Supplement)Pharmacokinetics of intramedullary administrated antibiotics infused from iMAP at Cadaver
- 2019, 骨折(Web), 41(Supplement) (Supplement)Histological analysis of the induced membrane of the patients whose bone defects were treated by the Masquelet technique
- 2019, 骨折(Web), 41(Supplement) (Supplement)Investigation of postoperative CT image evaluation method of femoral neck fracture
- 2019, 骨折(Web), 41(Supplement) (Supplement)Effect of explanation with document for improvement of patient compliance for low-intensity pulsed ultrasound (LIPUS) treatment
- (公社)日本理学療法士協会, 2019, 日本基礎理学療法学会学術大会プログラム・抄録集(Web), 24th(Suppl.1) (Suppl.1), 159 - 159, Japanese体外衝撃波療法は閉経後の骨粗鬆症を改善する
- 2019, 超音波骨折治療研究会プログラム・抄録集, 22nd, 30(JA),30‐31(EN), Japanese文書を用いた説明による超音波骨折治療器使用における患者コンプライアンス向上の試み
- (公社)日本整形外科学会, 2019, 日本整形外科学会雑誌, 93(2) (2), S113 - S113, Japanese整形外傷領域における再生医療
- 日本臨床分子医学会, 2019, 日本臨床分子医学会学術総会プログラム・抄録集, 62(Suppl) (Suppl), 71 - 71, Japanese骨格筋量制御におけるKLF15の機能の解析
- (株)メディカ出版, 2019, 整形外科Surgical Technique, 9(4) (4), 430 - 437, Japanese【大腿骨転子部骨折 もう怖くない不安定型の手術テクニック】手術法解説 偽関節とならないための転子下骨折の整復法 ワイヤリングの適応を含めて
- (一社)中部日本整形外科災害外科学会, 2019, 中部日本整形外科災害外科学会雑誌, 62(秋季学会) (秋季学会), 109 - 109, Japanese自己免疫性多内分泌腺症候群2型による続発性骨軟化症にて両側脛骨近位端骨折を生じた1例
- (公社)日本整形外科学会, 2019, 日本整形外科学会雑誌, 93(8) (8), S1622 - S1622, Japanese炭酸ガス経皮吸収はウサギ脛骨骨延長術における骨形成を促進する
- (公社)日本整形外科学会, 2019, 日本整形外科学会雑誌, 40th-37th(8) (8), S1749 - S1749, Japanese骨格筋量制御におけるKLF15の機能の解析
- (公社)日本整形外科学会, 2019, 日本整形外科学会雑誌, 93(8) (8), S1755 - S1755, Japanese炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおいて骨癒合を促進させる
- (株)医学書院, Dec. 2018, 臨床整形外科, 53(12) (12), 1087 - 1093, Japanese外傷における人工骨の臨床 RIA産物と人工骨の混合移植による骨欠損の再建
- (一社)日本マイクロサージャリー学会, Dec. 2018, 日本マイクロサージャリー学会学術集会プログラム・抄録集, 45回, 128 - 128, Japanese技術革新に伴うマイクロサージャリーの適応変化 Masquelet法とReamer Irrigator Aspiratorを用いた骨欠損・難治骨折の治療
- (株)ライフメディコム, Oct. 2018, カレントテラピー, 36(10) (10), 970 - 979, Japanese【骨粗鬆症診療の真の目的は何か?!-脆弱性骨折の予防と診療の最前線】脆弱性骨折の連鎖 ケーススタディから学ぶ
- (一社)日本骨折治療学会, Sep. 2018, 骨折, 40(4) (4), 1107 - 1110, Japanese下肢偽関節手術後に低出力超音波パルスを使用した症例についての検討
- 中部日本整形外科災害外科学会, Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 292 - 292, Japanese同側大腿骨・脛骨開放性骨折後の感染に対してヨードコーティング腫瘍用人工膝関節置換を行った1例
- (一社)日本骨折治療学会, Sep. 2018, 骨折, 40(4) (4), 1107 - 1110, Japanese下肢偽関節手術後に低出力超音波パルスを使用した症例についての検討
- (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1988 - S1988, JapaneseヒトiPS細胞による軟骨内骨化を介した骨再生療法
- (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1998 - S1998, Japanese
- (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1757 - S1757, Japanese222nm紫外線照射の安全性と殺菌効果の検討
- (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1877 - S1877, Japanese組織再生における血管新生 炭酸ガス経皮吸収がラットの筋組織に及ぼす影響
- (一社)日本骨折治療学会, Jul. 2018, 骨折, 40(Suppl.) (Suppl.), S208 - S208, Japanese
- (一社)日本骨折治療学会, Jul. 2018, 骨折, 40(Suppl.) (Suppl.), S450 - S450, Japanese
- (一社)日本骨折治療学会, Jul. 2018, 骨折, 40(Suppl.) (Suppl.), S495 - S495, Japanese
- (一社)中部日本整形外科災害外科学会, May 2018, 中部日本整形外科災害外科学会雑誌, 61(3) (3), 613 - 613, Japanese上腕骨骨幹部骨折術後偽関節に対してMIPO法にて治療した2例
- (一社)日本移植学会, Feb. 2018, 移植, 52(6) (6), 581 - 581, Japanese
- 2018, 超音波骨折治療研究会プログラム・抄録集, 21st, 48(JA),48‐49(EN), Japanese超音波骨折治療におけるコンプライアンス向上のための試み(第2報)
- 2018, 日本再生医療学会総会(Web), 17th, ROMBUNNO.P‐03‐076 (WEB ONLY), Japanese骨延長術における炭酸ガス経皮吸収の骨形成促進効果について
- 2018, 日本再生医療学会総会(Web), 17th, ROMBUNNO.SY‐35‐5 (WEB ONLY), Japanese難治性骨折患者を対象とした自家末梢血CD34陽性細胞移植療法―医師主導治験の経験から―
- (一社)中部日本整形外科災害外科学会, 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 292 - 292, Japanese同側大腿骨・脛骨開放性骨折後の感染に対してヨードコーティング腫瘍用人工膝関節置換を行った1例
- (公社)日本整形外科学会, 2018, 日本整形外科学会雑誌, 92(8) (8), S1757 - S1757, Japanese222nm紫外線照射の安全性と殺菌効果の検討
- (公社)日本整形外科学会, 2018, 日本整形外科学会雑誌, 92(8) (8), S1877 - S1877, Japanese組織再生における血管新生 炭酸ガス経皮吸収がラットの筋組織に及ぼす影響
- 中部日本整形外科災害外科学会, 2018, 中部日本整形外科災害外科学会雑誌, 61(春季学会) (春季学会), 114 - 114, Japaneseインプラント周囲での非定型大腿骨骨折の1例
- (公社)日本整形外科学会, 2018, 日本整形外科学会雑誌, 92(2) (2), S86 - S86, Japanese患者立脚型機能評価を含めた下肢偽関節治療経過の検討
- 日本骨・関節感染症学会, 2018, 日本骨・関節感染症学会プログラム・抄録集, 41st, 135 - 135, Japanese222nm紫外線照射の安全性および殺菌効果
- (公社)日本整形外科学会, 2018, 日本整形外科学会雑誌, 92(3) (3), S1238 - S1238, Japanese日本人におけるreamer irrigator aspirator(RIA)の使用経験
- (一社)日本骨折治療学会, 2018, 骨折, 40(Supplement) (Supplement), S208 - S208, Japanese患者立脚型機能評価を用いた下肢偽関節治療成績
- (一社)日本骨折治療学会, 2018, 骨折, 40(Supplement) (Supplement), S450 - S450, Japanese日本人におけるReamer irrigator aspirator:(RIA)の使用経験
- (一社)日本骨折治療学会, 2018, 骨折, 40(Supplement) (Supplement), S495 - S495, Japanese若年成人に発生した非定型大腿骨骨折の3例
- 中部日本整形外科災害外科学会, 2018, 中部日本整形外科災害外科学会雑誌, 61(3) (3), 613 - 613, Japanese上腕骨骨幹部骨折術後偽関節に対してMIPO法にて治療した2例
- (公社)日本整形外科学会, 2018, 日本整形外科学会雑誌, 92(8) (8), S1988 - S1988, JapaneseヒトiPS細胞による軟骨内骨化を介した骨再生療法
- (公社)日本整形外科学会, 2018, 日本整形外科学会雑誌, 92(8) (8), S1998 - S1998, Japaneseラット骨欠損モデルにおけるCO2経皮吸収の骨形成促進作用についての検討
- (株)ライフメディコム, 2018, カレントテラピー, 36(10) (10), 970 - 979, Japanese【骨粗鬆症診療の真の目的は何か?!-脆弱性骨折の予防と診療の最前線】 脆弱性骨折の連鎖 ケーススタディから学ぶ
- (一社)日本骨折治療学会, 2017, 骨折, 39(2) (2), 348 - 351, Japanese大腿骨転子部骨折術後合併症例に対する人工骨頭置換術についての検討[Refereed]Others
- (一社)日本骨折治療学会, 2017, 骨折, 39(2) (2), 444 - 447, Japanese足部重症開放骨折に対して足部温存を行った1例[Refereed]Others
- 日本運動器科学会, 2017, 運動器リハビリテーション, 28(1) (1), 16 - 24, Japanese【特殊な機器を用いた治療法】 炭酸ガス経皮吸収治療[Refereed]Others
- 中部日本整形外科災害外科学会, 2017, 中部日本整形外科災害外科学会雑誌, 60(4) (4), 713 - 714, Japanese[Refereed]Others
- 中部日本整形外科災害外科学会, 2017, 中部日本整形外科災害外科学会雑誌, 60(4) (4), 783 - 784, Japanese[Refereed]Others
- 中部日本整形外科災害外科学会, 2017, 中部日本整形外科災害外科学会雑誌, 60(5号) (5号), 907 - 908, Japanese[Refereed]Others
- 2017, 日本人工関節学会プログラム・抄録集, 47th人工骨頭置換術におけるJ-Taperステムの初期固定性について
- 2017, 移植(Web), 52(6) (6), 581(J‐STAGE), JapaneseCO2経皮吸収はラット骨欠損モデルにおいて骨形成を促進させる
- 中部日本整形外科災害外科学会, 2017, 中部日本整形外科災害外科学会雑誌, 60(春季学会) (春季学会), 80 - 80, Japanese変形性股関節症を伴った大腿骨転子部骨折に対する治療方針の検討
- 中部日本整形外科災害外科学会, 2017, 中部日本整形外科災害外科学会雑誌, 60(春季学会) (春季学会), 115 - 115, Japanese
- 中部日本整形外科災害外科学会, 2017, 中部日本整形外科災害外科学会雑誌, 60(5) (5), 160 - 160, Japanese持続洗浄と陰圧閉鎖療法を併用して治療した化膿性膝関節炎・大腿部ガス壊疽の1例
- (一社)日本骨折治療学会, 2017, 骨折, 39(Suppl.) (Suppl.), S74 - S74, Japanese炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる 臨床試験の報告
- (一社)日本骨折治療学会, 2017, 骨折, 39(Supplement) (Supplement), S295 - S295, Japanese偽関節手術後に低出力超音波パルスを使用した症例についての検討
- (一社)日本骨折治療学会, 2017, 骨折, 39(Suppl.) (Suppl.), S410 - S410, Japanese高齢者のBHA、THA後の寛骨臼骨折の治療について
- (公社)日本整形外科学会, 2017, 日本整形外科学会雑誌, 91(8) (8), S1481 - S1481, Japanese骨再生と骨癒合促進 CO2経皮吸収はラット骨欠損モデルにおける骨形成を促進させる
- (公社)日本整形外科学会, 2017, 日本整形外科学会雑誌, 91(8) (8), S1555 - S1555, Japanese炭酸ガス経皮吸収は骨折後の筋萎縮を軽減する
- (公社)日本整形外科学会, 2017, 日本整形外科学会雑誌, 91(8) (8), S1640 - S1640, Japanese骨折治癒過程におけるmicroRNAの発現 糖尿病・健常ラット間の比較検討
- 中部日本整形外科災害外科学会, 2017, 中部日本整形外科災害外科学会雑誌, 60(秋季学会) (秋季学会), 193 - 193, Japanese
- (一社)日本骨粗鬆症学会, 2017, 日本骨粗鬆症学会雑誌, 3(Suppl.1) (Suppl.1), 283 - 283, Japanese大腿骨近位部骨折を起こした高齢者におけるビタミンD充足度の調査
- (一社)日本人工関節学会, 2017, 日本人工関節学会誌, 47, 527 - 528, Japanese人工骨頭置換術におけるJ-Taperステムの初期固定性について
- (公社)日本整形外科学会, 2016, 日本整形外科学会雑誌, 90(2) (2), S156 - S156, Japanese大腿骨近位部骨折を起こした高齢者におけるビタミンD充足度の調査
- 日本創外固定・骨延長学会, 2016, 日本創外固定・骨延長学会雑誌, 27, 120 - 120, Japanese不安定型骨盤輪骨折における創外固定法の比較(第2報)
- (一社)日本外傷学会, 2016, 日本外傷学会雑誌, 30th(2) (2), 243 - 243, JapaneseMangled foot治療の小経験
- (一社)日本骨折治療学会, 2016, 骨折, 38(2) (2), 426 - 428, Japanese当科における大腿骨遠位単顆骨折の治療成績
- (一社)日本骨折治療学会, 2016, 骨折, 38(Supplement) (Supplement), S141 - S141, Japanese大腿骨近位部骨折を起こした高齢者におけるビタミンD充足度の調査
- (一社)日本骨折治療学会, 2016, 骨折, 38(Supplement) (Supplement), S185 - S185, Japanese足部重症開放骨折に対して足部温存を行った1例
- (一社)日本骨折治療学会, 2016, 骨折, 38(Supplement) (Supplement), S229 - S229, Japanese大腿骨転子部骨折術後合併症例に対する人工骨頭置換術についての検討
- (一社)日本骨折治療学会, 2016, 骨折, 38(Supplement) (Supplement), S237 - S237, JapaneseHansson Pinlocによる大腿骨頸部骨折に対して骨接合術の短期成績
- 中部日本整形外科災害外科学会, 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 296 - 296, Japanese踵骨骨折に合併した腓骨筋腱脱臼の7例
- (公社)日本リハビリテーション医学会, 2016, The Japanese Journal of Rehabilitation Medicine, 53(Supplement) (Supplement), I237 - I237, Japanese炭酸ガス経皮吸収は大腿骨骨折モデルの筋萎縮を軽減する
- (一社)日本マイクロサージャリー学会, 2016, 日本マイクロサージャリー学会学術集会プログラム・抄録集, 43rd, 183 - 183, Japanese骨欠損を伴うMangled foot(Gustilo type3B)の治療経験 足部再建におけるMasquelet法の有用性について
- (一社)日本骨粗鬆症学会, 2016, 日本骨粗鬆症学会雑誌, 2(Suppl.1) (Suppl.1), 301 - 301, Japanese淡路島における大腿骨近位部骨折治療と地域連携の現状と課題
- 2015, ファジィシステムシンポジウム講演論文集(CD-ROM), 31st骨盤ベルトの大腿骨大転子部周辺における負荷の左右差の評価
- (一社)日本骨折治療学会, 2015, 骨折, 37(1) (1), 70 - 74, Japanese不安定型骨盤輪骨折に対する新しい創外固定方法の検討(第2報)
- (一社)日本骨折治療学会, 2015, 骨折, 37(2) (2), 261 - 264, Japanese大腿骨転子部骨折 大腿骨転子部骨折の治療における合併症とその対策
- (一社)日本骨折治療学会, 2015, 骨折, 37(2) (2), 402 - 405, Japanese大腿骨転子部骨折に対するGamma 3 nailの術後X線学的検討について
- (一社)日本外傷学会, 2015, 日本外傷学会雑誌, 29th(2) (2), 222 - 222, Japanese多発外傷における整形外科の介入について
- (公社)日本整形外科学会, 2015, 日本整形外科学会雑誌, 89(2) (2), S280 - S280, Japanese人工股関節ステム周辺大腿骨骨折に対するロッキングプレート固定の治療成績 多施設後ろ向き研究
- (一社)日本骨折治療学会, 2015, 骨折, 37(Supplement) (Supplement), S167 - S167, Japaneseインプラント周囲大腿骨遠位部骨折に対し内側にLCP-PLTを使用した2例
- (一社)日本骨折治療学会, 2015, 骨折, 37(Supplement) (Supplement), S244 - S244, Japanese当院における大腿骨単顆骨折の治療成績
- 日本股関節学会, 2015, Hip Joint, 41, 973 - 976, Japanese大腿骨転子部骨折術後に骨頭下骨折を生じた2例
- 2014, 日本股関節学会学術集会プログラム・抄録集, 41st大腿骨転子部骨折術後に骨頭下骨折を生じた2例
- 2014, ファジィシステムシンポジウム講演論文集(CD-ROM), 30th骨盤ベルトの大腿骨大転子部周辺における応力分布計測システムの開発
- (一社)日本骨折治療学会, 2014, 骨折, 36(1) (1), 130 - 133, Japanese膝蓋骨骨折に対するTBW法とひまわり法の術後成績の検討
- (一社)日本骨折治療学会, 2014, 骨折, 36(2) (2), 332 - 335, Japanese当院におけるガンマ3ネイルのカットアウト症例の検討
- (公社)日本整形外科学会, 2014, 日本整形外科学会雑誌, 88(1) (1), 34 - 39, Japanese筋損傷を科学する 炭酸ガス経皮吸収の筋肉への効果
- (公社)日本整形外科学会, 2014, 日本整形外科学会雑誌, 88(3) (3), S569 - S569, Japanese大腿骨転子部骨折に対するGamma 3 nailの術後X線学的検討について
- (公社)日本リハビリテーション医学会, 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S267 - S267, Japanese
- (一社)日本骨折治療学会, 2014, 骨折, 36(Supplement) (Supplement), S26 - S27, Japanese転子部骨折 大腿骨転子部骨折の治療における合併症とその対策
- (一社)日本骨折治療学会, 2014, 骨折, 36(Supplement) (Supplement), S112 - S112, Japanese大腿骨転子部骨折に対するGamma 3 nailの術後X線学的検討について
- (一社)日本骨折治療学会, 2014, 骨折, 36(Supplement) (Supplement), S145 - S145, Japanese不安定型骨盤輪骨折に対する新しい創外固定法の検討(第2報)
- (一社)日本骨折治療学会, 2014, 骨折, 36(Supplement) (Supplement), S287 - S287, Japanese足関節外果剥離骨折を伴う腓骨筋腱脱臼を合併した距骨外側突起骨折の一例
- 日本股関節学会, 2014, Hip Joint, 40, 394 - 398, Japanese大腿骨転子部骨折に対するGamma 3 nailの術後X線学的検討について
- 2013, 日本股関節学会学術集会プログラム・抄録集, 40th大腿骨転子部骨折に対するGamma 3 nailの術後X線学的検討について
- 日本創外固定・骨延長学会, 2013, 日本創外固定・骨延長学会雑誌, 24, 158 - 158, Japanese不安定型骨盤輪骨折に対する新しい創外固定法の検討
- (公社)日本リハビリテーション医学会, 2013, Japanese Journal of Rehabilitation Medicine, 50(3) (3), 195 - 201, Japanese
- (公社)日本整形外科学会, 2013, 日本整形外科学会雑誌, 87(2) (2), S291 - S291, Japanese炭酸ガス経皮吸収は骨折治癒促進法となりうる
- (公社)日本リハビリテーション医学会, 2013, The Japanese Journal of Rehabilitation Medicine, 50(Suppl.) (Suppl.), S188 - S188, Japanese大腿骨転子部骨折術後における移動状態、ADLの予後予測因子の検討
- (公社)日本リハビリテーション医学会, 2013, The Japanese Journal of Rehabilitation Medicine, 50(Suppl.) (Suppl.), S232 - S232, Japanese経皮的炭酸ガス治療の筋肉量、脂肪量に対する影響
- (一社)日本骨折治療学会, 2013, 骨折, 35(Supplement) (Supplement), S77 - S77, Japanese当院におけるガンマ3ネイルのカットアウト症例の検討
- (一社)日本骨折治療学会, 2013, 骨折, 35(Supplement) (Supplement), S316 - S316, Japanese膝蓋骨骨折に対するひまわり法とTBW法の術後成績の検討
- (一社)日本骨折治療学会, 2013, 骨折, 35(3) (3), 550 - 553, Japanese尺骨鉤状突起骨折を伴う肘関節脱臼骨折の4症例
- (公社)日本リハビリテーション医学会, 2012, The Japanese Journal of Rehabilitation Medicine, 49(Suppl.) (Suppl.), S267 - S267, Japanese炭酸ガス経皮吸収が運動後のラットの筋肉に及ぼす影響について
- (公社)日本リハビリテーション医学会, 2012, The Japanese Journal of Rehabilitation Medicine, 49(Suppl.) (Suppl.), S267 - S267, Japanese骨折時の筋萎縮に対する、炭酸ガス治療の効果
- (株)南江堂, 2012, 別冊整形外科, (61) (61), 52 - 56, Japanese【難治性骨折に対する治療】 難治性骨折の治療(総論) 低出力超音波パルス(LIPUS) ヒト骨折血腫由来細胞およびヒト偽関節組織由来細胞を用いた低出力超音波パルスの作用機序の生物学的検討
- (公社)日本整形外科学会, 2012, 日本整形外科学会雑誌, 86(8) (8), S1225 - S1225, Japanese筋損傷を科学する 炭酸ガス経皮吸収の筋肉への効果
- (公社)日本整形外科学会, 2012, 日本整形外科学会雑誌, 86(8) (8), S1232 - S1232, Japanese炭酸ガス経皮吸収はラットの骨折治癒を促進する
- (公社)日本整形外科学会, 2012, 日本整形外科学会雑誌, 86(8) (8), S1268 - S1268, Japanese炭酸ガス経皮吸収が運動後のラットの筋肉に及ぼす影響について
- 中部日本整形外科災害外科学会, 2012, 中部日本整形外科災害外科学会雑誌, 55(3) (3), 655 - 656, Japanese
- (一社)日本骨折治療学会, 2012, 骨折, 34(3) (3), 536 - 538, Japanese不安定型骨盤輪骨折に対する新しい創外固定方法の検討(第1報)
- (一社)日本骨折治療学会, 2012, 骨折, 34(Supplement) (Supplement), S200 - S200, Japanese尺骨鉤状突起骨折を伴う肘関節脱臼骨折の4症例
- (一社)日本骨折治療学会, 2012, 骨折, 34(Supplement) (Supplement), S254 - S254, Japanese当科における大腿骨転子下骨折の治療成績
- (一社)日本骨折治療学会, 2012, 骨折, 34(Supplement) (Supplement), S282 - S282, Japanese大腿骨転子部骨折における急性期病院在院日数、総在院日数に影響する因子の検討
- (公社)日本整形外科学会, 2011, 日本整形外科学会雑誌, 85(2) (2), S144 - S144, Japanese骨盤・下肢骨折における静脈血栓塞栓症の発生状況
- (公社)日本整形外科学会, 2011, 日本整形外科学会雑誌, 85(3) (3), S630 - S630, JapaneseTrauma Center Murnauにおける鎖骨近位端骨折の観血的治療法について
- 金原出版(株), 2011, 整形・災害外科, 54(8) (8), 983 - 986, Japanese下肢外傷後軟部組織欠損に対する陰圧閉鎖療法用機器の使用経験
- (一社)日本骨折治療学会, 2011, 骨折, 33(2) (2), 515 - 519, Japaneseロッキングプレートを用いた偽関節・遷延治癒骨折手術の治療成績
- 中部日本整形外科災害外科学会, 2011, 中部日本整形外科災害外科学会雑誌, 54(3) (3), 445 - 446, Japanese
- (公社)日本整形外科学会, 2011, 日本整形外科学会雑誌, 85(8) (8), S1120 - S1120, Japanese非運動下における炭酸ガス経皮吸収がラットの前脛骨筋に及ぼす効果について
- (公社)日本整形外科学会, 2011, 日本整形外科学会雑誌, 85(8) (8), S1120 - S1120, Japanese炭酸ガス経皮投与のヒトにおける筋疲労回復に関する検討
- (公社)日本整形外科学会, 2011, 日本整形外科学会雑誌, 85(8) (8), S1182 - S1182, Japanese運動器の再生 末梢血細胞を用いた骨・血管再生療法による偽関節治療
- (公社)日本整形外科学会, 2011, 日本整形外科学会雑誌, 85(8) (8), S1209 - S1209, Japanese炭酸ガス経皮投与はラットの運動パフォーマンスを向上させる
- (一社)日本骨折治療学会, 2011, 骨折, 33(Supplement) (Supplement), S96 - S96, Japanese不安定型骨盤輪骨折に対する新しい創外固定法の検討
- (公社)日本リハビリテーション医学会, 2011, The Japanese Journal of Rehabilitation Medicine, 48(Suppl.) (Suppl.), S234 - S234, Japanese経皮炭酸ガス吸収のヒトにおける筋疲労回復、筋増強のメカニズムの解析 筋肉内pHとATP変化の検討
- 中部日本整形外科災害外科学会, 2011, 中部日本整形外科災害外科学会雑誌, 54(秋季学会) (秋季学会), 229 - 229, JapaneseHangman骨折に対して前方固定術を施行した1例
- (一社)日本骨折治療学会, 2011, 骨折, 33(4) (4), 889 - 891, Japanese股関節ブロックを併用した大腿骨頸部骨折に対する局所麻酔下骨接合術
- (公社)日本小児科学会, Dec. 2010, 日本小児科学会雑誌, 114(12) (12), 1947 - 1948, Japanese右腸骨に発症し急性虫垂炎様の症状を呈した急性化膿性骨髄炎の1例
- (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1109 - S1109, Japanese基礎研究をもとにした骨折治療の新しい流れ 末梢血CD34陽性細胞による骨・血管再生療法
- 2010, インテリジェント・システム・シンポジウム(CD-ROM), 20th人工培養骨内細胞のソフトコンピューティングによる評価システム
- 2010, 再生医療, 9, 297, Japanese末梢血CD34陽性細胞との共培養による骨折部血腫由来細胞の早期骨分化促進の検討
- (公社)日本リハビリテーション医学会, 2010, The Japanese Journal of Rehabilitation Medicine, 47(Suppl.) (Suppl.), S157 - S157, Japanese炭酸ガス経皮吸収によるラットの運動パフォーマンスへの効果
- (公社)日本リハビリテーション医学会, 2010, The Japanese Journal of Rehabilitation Medicine, 47(Suppl.) (Suppl.), S316 - S316, Japanese経皮炭酸ガス吸収による筋疲労、筋力増強に関する検討
- (公社)日本整形外科学会, 2010, 日本整形外科学会雑誌, 84(4) (4), S462 - S462, Japanese偽関節・遷延癒合の成因、治療成績と今後の課題
- (一社)日本骨折治療学会, 2010, 骨折, 32(Supplement) (Supplement), S12 - S12, JapaneseLocking plateの適応と限界 ロッキングプレートを用いた偽関節・遷延治癒骨折手術の治療成績
- (一社)日本骨折治療学会, 2010, 骨折, 32(Supplement) (Supplement), S123 - S123, Japanese大腿骨遠位部以遠の下肢骨折における静脈血栓塞栓症の診断状況
- (一社)日本骨折治療学会, 2010, 骨折, 32(Supplement) (Supplement), S246 - S246, Japaneseヒトの骨折血腫には多分化能を有する未分化細胞が存在する
- (一社)日本骨折治療学会, 2010, 骨折, 32(Supplement) (Supplement), S250 - S250, Japanese高齢者大腿骨頸部骨折に対し、股関節ブロックおよび局所麻酔にて骨接合術を施行した症例の検討
- (一社)日本骨折治療学会, 2010, 骨折, 32(Supplement) (Supplement), S255 - S255, Japanese骨移植と仙腸関節スクリューおよび創外固定にて治療した不安定型骨盤輪骨折後偽関節の1例
- (公社)日本整形外科学会, 2010, 日本整形外科学会雑誌, 84(8) (8), S1119 - S1119, Japanese低出力超音波パルスはBMP-7によるヒト骨折血腫由来細胞の骨分化を促進する
- (公社)日本整形外科学会, 2010, 日本整形外科学会雑誌, 84(8) (8), S1224 - S1224, Japanese炭酸ガス経皮吸収によるラットの下肢筋肉変化について
- (公社)日本整形外科学会, 2010, 日本整形外科学会雑誌, 84(8) (8), S1338 - S1338, Japaneseラット骨折モデルでの治癒群と偽関節群とにおけるIGFs/IGFBPsの遺伝子発現差異の検討
- 中部日本整形外科災害外科学会, 2010, 中部日本整形外科災害外科学会雑誌, 53(秋季学会) (秋季学会), 185 - 185, Japanese炭酸ガス経皮吸収によるBohr効果の証明 経皮炭酸ガス治療器を用いて
- (一社)日本骨折治療学会, 2010, 骨折, 32(3) (3), 512 - 517, Japanese骨盤骨折と大腿骨骨折における静脈血栓塞栓症の診断
- (一社)日本臨床スポーツ医学会, 2010, 日本臨床スポーツ医学会誌, 18(4) (4), S130 - S130, Japanese炭酸ガス経皮吸収によるラットの運動パフォーマンスへの影響
- 中部日本整形外科災害外科学会, 2010, 中部日本整形外科災害外科学会雑誌, 53(6) (6), 1433 - 1433, Japanese下肢外傷後軟部組織欠損に対するV.A.C.ATS治療システムの使用経験
- (公社)日本生化学会, 2010, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回, 4P - 1029, Japanese炭酸ガス経皮吸収は骨格筋の有酸素系代謝を向上させる
- (公社)日本整形外科学会, 2009, 日本整形外科学会雑誌, 83(3) (3), S549 - S549, Japanese多発骨折例を含む骨盤、下肢骨折症例における静脈血栓塞栓症の発生状況
- (公社)日本リハビリテーション医学会, 2009, The Japanese Journal of Rehabilitation Medicine, 46(Suppl.) (Suppl.), S184 - S184, Japanese生体内における炭酸ガス経皮吸収によるBohr効果の証明 新開発の経皮炭酸ガス治療器を用いて
- 中部日本整形外科災害外科学会, 2009, 中部日本整形外科災害外科学会雑誌, 52(春季学会) (春季学会), 123 - 123, Japanese骨盤骨折症例における静脈血栓塞栓症の診断
- (一社)日本骨折治療学会, 2009, 骨折, 31(2) (2), 405 - 409, Japanese肥厚性偽関節の治療成績 偽関節組織の生物学的活性という視点より検討する
- (一社)日本骨折治療学会, 2009, 骨折, 31(2) (2), 410 - 413, Japanese大腿骨、脛骨の偽関節に対する髄内釘入れ替えと骨髄刺激、自家骨移植による偽関節手術
- 中部日本整形外科災害外科学会, 2008, 中部日本整形外科災害外科学会雑誌, 51(春季学会) (春季学会), 79 - 79, Japanese骨接合術が困難なpilon骨折に対するサルベージ手術としての順行性髄内釘法による足関節固定術
- (一社)日本骨折治療学会, 2008, 骨折, 30(Supplement) (Supplement), S164 - S164, Japanese肥厚性偽関節の治療成績 偽関節組織の生物学的活性という視点より検討する
- (一社)日本骨折治療学会, 2008, 骨折, 30(Supplement) (Supplement), S165 - S165, Japanese大腿骨、脛骨の偽関節に対する髄内釘入れ替えと自家骨移植による偽関節手術
- 中部日本整形外科災害外科学会, 2008, 中部日本整形外科災害外科学会雑誌, 51(3) (3), 568 - 569, Japanese不安定型骨盤輪骨折後の偽関節に対して偽関節手術を行った1例
- (公社)日本整形外科学会, 2008, 日本整形外科学会雑誌, 82(8) (8), S1157 - S1157, JapaneseFas ligandはラット由来骨髄間葉系細胞の骨分化を抑制する
- (公社)日本整形外科学会, 2008, 日本整形外科学会雑誌, 82(8) (8), S1195 - S1195, Japaneseヒト新鮮骨折において、低出力超音波パルス(LIPUS)は骨折血腫細胞の骨分化を促進する
- (公社)日本整形外科学会, 2008, 日本整形外科学会雑誌, 82(8) (8), S1259 - S1259, Japaneseヒトの骨折治癒過程に携わる骨折血腫細胞には骨形成蛋白が発現している
- 中部日本整形外科災害外科学会, 2008, 中部日本整形外科災害外科学会雑誌, 51(秋季学会) (秋季学会), 124 - 124, Japanese楔状骨脱臼、脱臼骨折の治療経験
- (公社)日本顎顔面インプラント学会, 2008, Japanese Journal of Maxillo Facial Implants, 7(2) (2), 171 - 171, Japanese骨折血腫細胞の多分化能についての検討と低出力超音波パルス(LIPUS)による効果について
- Sep. 2007, JOURNAL OF BONE AND MINERAL RESEARCH, 22, S242 - S242, EnglishNondestructive evaluation of cell numbers in bone marrow stromal cells biodegradable scaffold composites using ultrasound.Summary international conference
- In these years, a composite of artificial culture bone and bone marrow stromal cells (BMSCs) are hoped to effective treatment to large bone defect as impossible to curing for natural healing. Conventional evaluation method for the cellular quantity is firstly to crush the artificial culture bone injected BMSCs. So, the approximate amount of cell for curing is unknown. Therefore, this paper describes an ultrasound evaluation system for cellular quantity of artificial culture bone. Our system firstly measures ultrasound wave into the composite. And, we obtain two characteristics values. One of these values, the amplitude value, is directly measured by obtained wave. Another the frequency value is calculated by frequency spectrum converted with cross-spectrum method. We employ fuzzy inference using correlation of these values and true quantity for the cellular quantity. As a result, our method is able to evaluate the quantity with high accuracy.Japan Society for Fuzzy Theory and Intelligent Informatics, 2007, ファジィシステムシンポジウム講演論文集(CD-ROM), 23rd(0) (0), 739 - 739, Japanese
- (株)メジカルビュー社, 2007, 関節外科, 26(4月増刊) (4月増刊), 122 - 125, Japanese【研修医が知っておきたい整形外科診療必須マニュアル】 初期治療必須手技 脱臼と靱帯損傷
- 中部日本整形外科災害外科学会, 2007, 中部日本整形外科災害外科学会雑誌, 50(2) (2), 364 - 364, Japanese高度に粉砕したpilon骨折に対し順行性髄内釘を用い足関節固定術を施行した1例
- (一社)日本骨折治療学会, 2007, 骨折, 29(Supplement) (Supplement), S209 - S209, Japanese整復固定が困難な脛骨天蓋骨折に対するサルベージ手術としての順行性髄内釘法による足関節固定術の経験
- (公社)日本整形外科学会, 2007, 日本整形外科学会雑誌, 81(8) (8), S1143 - S1143, Japanese偽関節部の組織には多分化能を有する細胞が存在する
- (公社)日本整形外科学会, 2007, 日本整形外科学会雑誌, 81(8) (8), S1146 - S1146, Japanese超音波を利用した骨髄細胞/人工骨複合体内導入細胞数の非破壊的定量法の開発
- (公社)日本口腔インプラント学会, 2007, 日本口腔インプラント学会誌, 37th(1) (1), 199 - 199, Japaneseβ-リン酸三カルシウム(β-TCP)内への骨髄幹細胞(BMSC)導入方法と骨形成能の検討
- The Japan Joint Automatic Control Conference, 2006, 自動制御連合講演会(CD-ROM), 49th(0) (0), 95 - 95
- In this paper, we propose an ultrasonic nondestructive evaluation method for estimating cellular quantity in artificial culture bone by analyzing the ultrasonic wave. In order to measure the cellular quantity, we have to crush the culture bone and observed by the electro microscope. Therefore, they can't use the crashed culture bone in the research and the clinical. So we transmit ultrasound over the culture bone injected stem cell for getting a wave pattern. Our method analyzes these waves by fuzzy inference. As a result, we can estimate cellular quantity in culture bone with 60% accuracy.Japan Society for Fuzzy Theory and Intelligent Informatics, 2006, ファジィシステムシンポジウム講演論文集(CD-ROM), 22nd(0) (0), 99 - 99, Japanese
- 中部日本整形外科災害外科学会, 2006, 中部日本整形外科災害外科学会雑誌, 49(1) (1), 189 - 189, JapaneseVAC(Vaccum assisted closure)を用いて治癒し得た膝蓋骨骨折術後広範囲軟部組織欠損の1例
- (一社)日本脊椎脊髄病学会, 2006, 日本脊椎脊髄病学会雑誌, 17(1,Pt.2) (1,Pt.2), 534 - 534, Japanese頸髄サルコイドーシスの4例(病態,画像の特徴,圧迫性脊髄症との鑑別および治療指針についての検討)
- 中部日本整形外科災害外科学会, 2006, 中部日本整形外科災害外科学会雑誌, 49(4) (4), 803 - 803, Japanese上腕三頭筋腱皮下断裂を生じた2例
- (株)南江堂, 2006, 別冊整形外科, (50) (50), 2 - 8, Japanese【脊椎疾患における鑑別診断と治療法選択の根拠】 鑑別診断とその根拠 頸椎 頸髄症とサルコイドーシス、多発性硬化症などの鑑別 頸椎症性脊髄症と脊髄サルコイドーシスの鑑別
- (株)南江堂, 2006, 整形外科, 57(13) (13), 1737 - 1740, JapaneseVacuum-assisted closureを用いて治癒しえた膝蓋骨骨折術後広範囲軟部組織欠損の1例
- (公社)日本整形外科学会, 2006, 日本整形外科学会雑誌, 80(8) (8), S969 - S969, Japanese骨折血腫には多分化能を有する細胞が存在する
- (一社)日本救急医学会, Aug. 2005, 日本救急医学会雑誌, 16(8) (8), 386 - 386, Japanese肺経由動脈熱希釈法(PiCCO)を用いた呼吸・循環動態のモニタリングの検討
- (一社)日本救急医学会, 2005, 日本救急医学会雑誌, 16(8) (8), 336 - 336, Japanese臨床研修必修化と国立大学独立法人化に伴う諸問題
- (一社)日本救急医学会, 2005, 日本救急医学会雑誌, 16(8) (8), 451 - 451, Japanese骨盤骨折に対するTAE(経カテーテル的動脈塞栓術)の適応 無輸血治療をめざして
- (一社)日本救急医学会, 2005, 日本救急医学会雑誌, 16(8) (8), 458 - 458, JapaneseCPAOA症例における搬入時直腸温と鼓膜温の解離についての検討(第2報)
- 中部日本整形外科災害外科学会, 2004, 中部日本整形外科災害外科学会雑誌, 47(春季学会) (春季学会), 152 - 152, Japanese頸椎症性脊髄症と鑑別を必要とした脊髄サルコイドーシスの4例
- 中部日本整形外科災害外科学会, 2004, 中部日本整形外科災害外科学会雑誌, 47(3) (3), 598 - 598, Japanese頸椎多椎間後方除圧固定術術後に発症したC5麻痺の2例
- 中部日本整形外科災害外科学会, 2004, 中部日本整形外科災害外科学会雑誌, 47(5) (5), 1117 - 1117, Japanese踵部難治性潰瘍に対して分層植皮を施行したWerner症候群の1例
- 中部日本整形外科災害外科学会, 2004, 中部日本整形外科災害外科学会雑誌, 47(6) (6), 1205 - 1206, Japanese
- 中部日本整形外科災害外科学会, Jul. 2003, 中部日本整形外科災害外科学会雑誌, 46(4) (4), 767 - 767, Japanese上腕三頭筋腱皮下断裂を生じた1例
- 三田市民病院, Mar. 2003, 三田市民病院誌, 15, 7 - 11, Japanese当院における鏡視下腰椎椎間板ヘルニア切除術
- (株)メジカルビュー社, 2003, 関節外科, 22(1) (1), 116 - 118, JapaneseFemoral neck fracture after removal of the gamma nail. A case report.
- (公社)日本整形外科学会, 2003, 日本整形外科学会雑誌, 77(3) (3), S37 - S37, Japanese大腿骨頸部外側骨折に対するProximal Femoral Nail(PFN)を使用した治療成績
- (一社)日本骨折治療学会, 2003, 骨折, 25(2) (2), 630 - 632, Japanese上腕骨近位部骨折に対するPolarus nailの使用経験
- (一社)日本骨折治療学会, 2003, 骨折, 25(2) (2), 701 - 704, Japanese小児上腕骨顆上骨折に同側の前腕骨遠位部骨折を合併した3例
- 日本足の外科学会, May 2002, 日本足の外科学会雑誌, 23(1) (1), S98 - S98, JapaneseCharcot足関節症に対してallograftを用いて足関節固定術を行った一例
- (株)メジカルビュー社, 2002, 関節外科, 21(4) (4), 498 - 500, JapanesePartial rupture of the extensor pollicis longus tendon combined with avulsion fracture of the Lister tubercle.
- (株)文光堂, 2002, 臨床スポーツ医学, 19(7) (7), 829 - 833, JapaneseMosaicplasty後に骨軟骨プラグ採取部膨隆による疼痛を生じた1例
- (一社)日本骨折治療学会, 2002, 骨折, 24(1) (1), 323 - 326, JapaneseUnreamed nailによる下腿開放骨折の治療
- 兵庫県立がんセンター, 2000, 兵庫県立成人病センター紀要, 17, 27 - 30, JapaneseElastofibroma dorsi found incidentally in the follow-up of a treated lung cancer: A case report.
- 整形外科と災害外科, May 2024, Japanese, 西日本整形・災害外科学会骨折関連感染症に対する持続局所抗菌薬灌流(CLAP)の有効性 多施設研究
- 整形外科と災害外科, May 2024, Japanese, 西日本整形・災害外科学会持続局所抗菌薬灌流(CLAP)が骨折関連感染症治療における医療費に与える影響
- 日本外科学会定期学術集会抄録集, Apr. 2024, Japanese, (一社)日本外科学会細菌性腹膜炎への腹腔内222nmUVC照射による腹水中細菌制御効果と安全性の検証
- 中部日本整形外科災害外科学会雑誌, Apr. 2024, Japanese, (一社)中部日本整形外科災害外科学会当院の二次性骨折予防継続管理の取り組みとその成果
- 中部日本整形外科災害外科学会雑誌, Apr. 2024, Japanese, (一社)中部日本整形外科災害外科学会人工股関節ステム周囲骨折後偽関節の治療経験
- 中部日本整形外科災害外科学会雑誌, Apr. 2024, Japanese, (一社)中部日本整形外科災害外科学会膝関節が露出した膝蓋骨骨折術後感染をCLAPと腓腹筋弁によりサルベージした一例
- 中部日本整形外科災害外科学会雑誌, Apr. 2024, Japanese, (一社)中部日本整形外科災害外科学会人工膝関節全置換術後の細菌感染治療経過中に真菌感染をきたし、一期的に再置換術を施行した一例
- 整形・災害外科, Apr. 2024, Japanese, 金原出版(株)【骨折治療の現在地を知る!】感染・偽関節 偽関節患者に対する自家末梢血CD34陽性細胞移植による骨・血管再生医療について
- 日本整形外科学会雑誌, Mar. 2024, Japanese, (公社)日本整形外科学会非定型大腿骨骨折において骨転移に対する骨修飾薬使用歴の有無が治療経過に与える影響
- 日本整形外科学会雑誌, Mar. 2024, Japanese, (公社)日本整形外科学会大腿骨近位部骨折の早期手術を妨げる要因は何か
- 日本整形外科学会雑誌, Mar. 2024, Japanese, (公社)日本整形外科学会CLAPにおけるゲンタマイシンの薬物動態に関する検討
- 日本整形外科学会雑誌, Mar. 2024, Japanese, (公社)日本整形外科学会骨折関連感染症に対する持続局所抗菌薬灌流の有効性 多施設研究
- 日本整形外科学会雑誌, Mar. 2024, Japanese, (公社)日本整形外科学会AMED事業で進む運動器再生医療-臨床研究と医師主導治験- 多施設医師主導治験「自家末梢血CD34陽性細胞移植による骨・血管再生」
- 日本整形外科学会雑誌, Mar. 2024, Japanese, (公社)日本整形外科学会骨折関連感染症に対する有効性と安全性を意識した持続局所抗菌薬灌流(CLAP)の実際
- 中部日本整形外科災害外科学会雑誌, Oct. 2023, Japanese, (一社)中部日本整形外科災害外科学会四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果
- 中部日本整形外科災害外科学会雑誌, Oct. 2023, Japanese, (一社)中部日本整形外科災害外科学会Mycobacterium abscessus complex感染による骨髄炎・化膿性関節炎を持続局所抗菌薬灌流で治療した一例
- 中部日本整形外科災害外科学会雑誌, Oct. 2023, Japanese, (一社)中部日本整形外科災害外科学会特徴的画像所見を示した脛骨慢性骨髄炎の一例
- 中部日本整形外科災害外科学会雑誌, Sep. 2023, Japanese, (一社)中部日本整形外科災害外科学会前十字靱帯再建術後感染に対して持続局所抗菌薬灌流療法を行い,移植腱を温存し得たプロサッカー選手の1例
- 日本整形外科学会雑誌, Aug. 2023, Japanese, (公社)日本整形外科学会3D造形βTCP人工骨の生体活性の検討
- 日本整形外科学会雑誌, Aug. 2023, Japanese, (公社)日本整形外科学会異なる抗菌薬濃度により骨髄由来細胞が受ける影響の検討
- 日本整形外科学会雑誌, Aug. 2023, Japanese, (公社)日本整形外科学会Masquelet法induced membrane由来細胞に対するLIPUSの骨分化促進効果の検討
- 日本整形外科学会雑誌, Aug. 2023, Japanese, (公社)日本整形外科学会廃用性骨萎縮・筋萎縮に対する炭酸ガス経皮吸収の予防効果
- 第49回日本骨折治療学会学術集会, Jul. 2023, Japanese大腿骨頚部骨折患者における骨粗鬆症治療薬介入とステム周囲骨密度変化率の関係について―多施設共同研究―Oral presentation
- 第49回日本骨折治療学会学術集会, Jun. 2023, Japanese当院における慢性骨髄炎に対する持続局所抗菌薬灌流療法（CLAP）の治療成績Oral presentation
- 第46回日本骨・関節感染症学会, Jun. 2023, Japanese当院における化膿性関節炎に対する持続局所抗菌薬灌流療法（CLAP）の治療成績Oral presentation
- 骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会大腿骨骨欠損をMasquelet法で治療する際の移植骨局所担持のための工夫
- 骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会CLAP(1) 骨髄由来細胞に対する高濃度抗菌薬の影響
- 骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会CLAP(1) 当院における慢性骨髄炎に対する持続局所抗菌薬灌流療法(CLAP)の治療成績
- 骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会LIPUSのMasquelet法induced membrane由来細胞に対する骨分化促進効果の検討
- 骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会がん骨転移に対する骨修飾薬使用歴が非定型大腿骨骨折の治療経過に与える影響に関する後ろ向き観察研究
- 骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果
- 骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会当院ヒップフラクチャーセンターにおける二次性骨折予防継続管理料、緊急整復固定・緊急挿入加算算定の状況
- 骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会Hip fracture templateは大腿骨近位部骨折手術における周術期合併症を減少させる
- 骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会大腿骨頸部骨折患者における骨粗鬆症治療薬介入とステム周囲骨密度変化率の関係について 多施設共同研究
- 骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会炭酸ガス経皮吸収と低出力超音波パルス療法(LIPUS)併用のラット大腿骨骨折治癒に対する効果
- 骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会Mycobacterium abscessus complex感染による骨髄炎・化膿性関節炎を持続局所抗菌薬灌流で治療した一例
- 日本骨・関節感染症学会プログラム・抄録集, Jun. 2023, Japanese, (一社)日本骨・関節感染症学会高濃度抗菌薬が骨髄由来細胞の増殖能および分化能に与える影響
- 日本骨・関節感染症学会プログラム・抄録集, Jun. 2023, Japanese, (一社)日本骨・関節感染症学会CLAPにおけるゲンタマイシンの血中濃度、排液中濃度と排液量の関係
- 日本骨・関節感染症学会プログラム・抄録集, Jun. 2023, Japanese, (一社)日本骨・関節感染症学会持続局所抗菌薬灌流(CLAP)による骨折関連感染症の骨癒合経過 多施設研究
- 第96回日本整形外科学会学術総会, May 2023, Japanese骨SPECT/CTにおける偽関節モデルファントムを用いた金属インプラントのCT減弱補正に関する研究Oral presentation
- 外傷整形外科webシンポジウム AFF 骨折研究会, Apr. 2023, Japaneseインプラント周囲に生じた非定型大腿骨骨折について[Invited]Nominated symposium
- 超音波医学, Apr. 2023, Japanese, (公社)日本超音波医学会超音波治療の世界(基礎と臨床) LIPUSによる骨折治癒促進
- 第25回救急整形外傷シンポジウム, Mar. 2023, Japanese軟部組織欠損を伴った脛骨慢性骨髄炎病的骨折に対するCLAPを用いた新しい治療戦略Oral presentation
- 日本整形外科学会雑誌, Mar. 2023, Japanese, (公社)日本整形外科学会Hip fracture templateは大腿骨近位部骨折手術における周術期合併症を減少させる
- 中部日本整形外科災害外科学会雑誌, Mar. 2023, Japanese, (一社)中部日本整形外科災害外科学会メッシュプレートを用いて内固定を行った母趾基節骨偽関節の2例
- 日本整形外科学会雑誌, Mar. 2023, Japanese, (公社)日本整形外科学会骨SPECT/CTにおける偽関節モデルファントムを用いた金属インプラントのCT減弱補正に関する研究
- 日本整形外科学会雑誌, Mar. 2023, Japanese, (公社)日本整形外科学会ここまできた!骨・軟骨再生医療の最前線 偽関節患者に対する自家末梢血CD34陽性細胞移植による骨・血管再生医療
- 日本整形外科学会雑誌, Mar. 2023, Japanese, (公社)日本整形外科学会四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果
- 日本整形外科学会雑誌, Mar. 2023, Japanese, (公社)日本整形外科学会患者立脚型QOL評価を用いた大腿骨および脛骨偽関節の術後成績の検討
- 中部日本整形外科災害外科学会雑誌, Mar. 2023, Japanese, (一社)中部日本整形外科災害外科学会脛骨慢性骨髄炎病的骨折に対しCLAPを併用し骨接合術と遊離皮弁術を同時に行った1例
- 第49回日本股関節学会学術集会, Oct. 2022, Japaneseインプラント周囲非定型大腿骨骨折の病態と治療法について[Invited]Nominated symposium
- 第169回 神戸地区症例検討会, Sep. 2022, Japanese骨・軟部組織感染症の診断と治療Public discourse
- Sep. 2022, Japanese創外固定の基礎[Invited]Public discourse
- 日本整形外科学会雑誌, Sep. 2022, Japanese, (公社)日本整形外科学会炭酸ガス経皮吸収療法と低出力超音波パルス療法(LIPUS)の併用はラットの骨折治癒を促進する
- 日本整形外科学会雑誌, Sep. 2022, Japanese, (公社)日本整形外科学会Masquelet法 Induced membrane由来細胞に対するLIPUSによる骨分化誘導
- 日本整形外科学会雑誌, Sep. 2022, Japanese, (公社)日本整形外科学会Non-hypertrophic nonunionには骨分化能を有する細胞が存在し、E-BMP-2により骨・軟骨分化能が促進される
- 日本整形外科学会雑誌, Sep. 2022, Japanese, (公社)日本整形外科学会骨折遷延治癒、偽関節のメカニズムから臨床応用へ 炭酸ガス経皮吸収による骨癒合促進
- 日本整形外科学会雑誌, Sep. 2022, Japanese, (公社)日本整形外科学会骨組織由来細胞に対する高濃度抗菌薬の影響
- 第48回日本骨折治療学会学術集会, Jun. 2022, Japanese寛骨臼転移性骨腫瘍に対して病巣掻爬後に内固定および骨セメント充填を行った3例[Invited]Nominated symposium
- 第48回日本骨折治療学会学術集会, Jun. 2022, Japanese高齢大腿骨頚部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化について-多施設共同研究-Oral presentation
- May 2022, Japanese高齢大腿骨頚部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について ―多施設共同前向き観察研究―Oral presentation
- 第95回日本整形外科学会学術総会, May 2022, JapaneseCT有限要素法を用いたReamer Irrigator Aspirator施行前後の大腿骨強度変化についての検討Poster presentation
- 第138回中部日本整形外科災害外科学会・学術集会, Apr. 2022, Japanese大腿骨近位髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について―多施設共同前向き観察研究―Oral presentation
- 糖尿病, Apr. 2022, Japanese, (一社)日本糖尿病学会KLF15を介した筋萎縮の分子機構の解明
- 中部日本整形外科災害外科学会雑誌, Apr. 2022, Japanese, (一社)中部日本整形外科災害外科学会骨形成不全症患者に生じた非定型大腿骨骨折の1例
- 中部日本整形外科災害外科学会雑誌, Apr. 2022, Japanese, (一社)中部日本整形外科災害外科学会大腿骨近位髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について 多施設共同前向き観察研究
- 日本整形外科学会雑誌, Mar. 2022, Japanese, (公社)日本整形外科学会偽関節治療の基礎研究と臨床応用
- 日本整形外科学会雑誌, Mar. 2022, Japanese, (公社)日本整形外科学会非定型大腿骨骨折の病態と治療 非定型大腿骨骨折の病態と疫学
- 日本整形外科学会雑誌, Mar. 2022, Japanese, (公社)日本整形外科学会小児整形外科疾患に対する新しい治療法-その展望および問題点- 先天性下腿偽関節症に対するMasquelet法を用いた治療経験
- 日本整形外科学会雑誌, Mar. 2022, Japanese, (公社)日本整形外科学会高齢大腿骨頸部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について 多施設共同前向き観察研究
- 日本整形外科学会雑誌, Mar. 2022, Japanese, (公社)日本整形外科学会患者立脚型機能評価を用いた上肢偽関節の治療成績の検討
- 日本整形外科学会雑誌, Mar. 2022, Japanese, (公社)日本整形外科学会CT有限要素法を用いたreamer irrigator aspirator施行前後の大腿骨強度変化についての検討
- 日本整形外科学会雑誌, Mar. 2022, Japanese, (公社)日本整形外科学会難治性骨折に対する自家CD34陽節細胞移植 医師主導治験の成果報告
- Orthopaedic Research Society 2022 Annual Meeting, Feb. 2022, EnglishRelationship between proximal femoral morphology and bone mineral density around the stem in patients with femoral neck fracture: A multicenter prospective cohort studyPoster presentation
- 第16回兵庫転移性骨腫瘍治療研究会, Feb. 2022, Japanese寛骨臼転移性腫瘍に対して病巣搔爬後に内固定および骨セメント充填を行った3例Oral presentation
- 第25回超音波骨折治療研究会, Jan. 2022, Japanese超音波骨折治療器使用における患者コンプライアンス向上の工夫[Invited]Public discourse
- 第36回日本整形外科学会基礎学術集会, Oct. 2021, JapaneseMasquelet法の根幹をなすinduced membraneについての組織学的研究[Invited]Nominated symposium
- 日本環境感染学会総会プログラム・抄録集, Sep. 2021, Japanese, (一社)日本環境感染学会222nm UVCのヒトに対する安全性と有効性
- 日本骨粗鬆症学会雑誌, Sep. 2021, Japanese, (一社)日本骨粗鬆症学会糖尿病性骨症の病態と臨床疫学 整形外科から見た糖尿病患者の骨折とそのマネジメント
- 中部日本整形外科災害外科学会雑誌, Sep. 2021, Japanese, (一社)中部日本整形外科災害外科学会Klippel-Trenaunay症候群の患者に生じた大腿骨感染性偽関節に対する治療経験
- 兵庫県整形外科医会 骨関節フォーラム, Aug. 2021, Japanese難治骨折の診断と治療[Invited]Public discourse
- 日本整形外科学会雑誌, Aug. 2021, Japanese, (公社)日本整形外科学会偽関節、感染性偽関節の基礎研究と臨床応用 偽関節患者への自家末梢血CD34陽性細胞移植
- 日本整形外科学会雑誌, Aug. 2021, Japanese, (公社)日本整形外科学会偽関節、感染性偽関節の基礎研究と臨床応用 Masquelet法の根幹をなすinduced membraneについての組織学的研究
- 日本整形外科学会雑誌, Aug. 2021, Japanese, (公社)日本整形外科学会ヒトinduced membraneにおけるbone morphogenetic proteins(BMP)発現の検討
- 第47回日本骨折治療学会学術集会, Jul. 2021, Japanese有限要素法を用いたReamer Irrigator Aspirator施行前後の大腿骨強度評価の検討Oral presentation
- 第47回日本骨折治療学会学術集会, Jul. 2021, EnglishThe pathophysiology of;peri;rosthetic atypical femoral fracture[Invited]Nominated symposium
- 骨折, Jul. 2021, Japanese, (一社)日本骨折治療学会トップアスリートの外傷・障害とその治療
- 骨折, Jul. 2021, Japanese, (一社)日本骨折治療学会AFFの治療 インプラント周囲に発生した非定型大腿骨骨折について
- 骨折, Jul. 2021, Japanese, (一社)日本骨折治療学会治療に難渋する骨折 偽関節に対する低出力超音波パルス療法の有効性
- 骨折, Jul. 2021, Japanese, (一社)日本骨折治療学会治療に難渋する骨折 偽関節治療への新たなアプローチ
- 骨折, Jul. 2021, Japanese, (一社)日本骨折治療学会骨修飾薬使用中の悪性腫瘍骨転移患者に発生した非定型大腿骨骨折の治療経過に関する多施設共同研究
- 第14回姫路骨折治療セミナー, Jun. 2021, Japanese難治骨折診療の立場からみた大腿骨近位部骨折[Invited]Public discourse
- 理学療法学, Mar. 2021, Japanese, (公社)日本理学療法士協会体外衝撃波療法は閉経後の骨粗鬆症を改善する
- 核医学, 2021, English, (一社)日本核医学会非感染性偽関節に対する骨SPECTの定量評価(Quantitative evaluation of bone SPECT for uninfected nonunion)
- 中部日本整形外科災害外科学会雑誌, Jan. 2021, Japanese, (一社)中部日本整形外科災害外科学会寛骨臼の転移性骨腫瘍に対して骨セメント充填およびスクリューによる内固定を行った2例
- 人工骨頭集中講座 in West Japan, Dec. 2020, Japanese大腿骨近位部骨折の診断と治療[Invited]Public discourse
- 中部日本整形外科災害外科学会雑誌, Oct. 2020, Japanese, (一社)中部日本整形外科災害外科学会寛骨臼の転移性骨腫瘍に対して骨セメント充填及びスクリューによる内固定を行った2例
- 日本整形外科学会雑誌, Sep. 2020, Japanese, (公社)日本整形外科学会卵巣摘出ラット骨粗鬆症モデルにおける炭酸ガス経皮吸収による骨粗鬆症改善効果の検討
- 日本整形外科学会雑誌, Sep. 2020, Japanese, (公社)日本整形外科学会ウサギを用いた222nm紫外線術野照射の安全性の検討
- 日本整形外科学会雑誌, Sep. 2020, Japanese, (公社)日本整形外科学会炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおける骨折治癒を促進させる
- 日本整形外科学会雑誌, Sep. 2020, Japanese, (公社)日本整形外科学会骨折治癒過程を超音波の周波数特性により推定する試み
- 日本整形外科学会雑誌, Sep. 2020, Japanese, (公社)日本整形外科学会男性骨粗鬆症モデルラットに対する炭酸ガス経皮吸収の影響に関する検討
- 日本整形外科学会雑誌, 2020, Japanese, (公社)日本整形外科学会炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる-臨床試験の報告-
- 第15回 神戸整形外科外傷セミナー, Aug. 2019, Japanese, Domestic conference創外固定の基礎[Invited]
- 第45回日本骨折治療学会, Jun. 2019, Japanese, Domestic conference大腿骨頚部骨折の術後CT画像評価方法の検討Oral presentation
- 骨折, Jun. 2019, Japanese, (一社)日本骨折治療学会Masquelet法で治療した患者におけるinduced membraneの組織学的評価
- 骨折, Jun. 2019, Japanese, (一社)日本骨折治療学会下肢長管骨偽関節に対するロッキングプレートを用いた手術の治療成績
- 骨折, Jun. 2019, Japanese, (一社)日本骨折治療学会文書を用いた患者説明によるLIPUSコンプライアンス向上の効果
- 骨折, Jun. 2019, Japanese, (一社)日本骨折治療学会大腿骨頸部骨折の術後CT画像評価方法の検討
- 第16回 ORS ISFR2018, Nov. 2018, English, International conferencePeriprosthetic femoral fracture with characteristics of atypical femoral fracture -A case report-
- 第16回 ORS ISFR2018, Nov. 2018, English, International conferenceClinical experience of using Reamer-Irrigator-Aspirator system for Japanese patientsOral presentation
- ORS ISFR2018, Nov. 2018, English, International conferenceMinimally invasive plate osteosynthesis for the treatment of humeral shaftOral presentation
- 若手整形外科のための”ここだけはおさえておこう”髄内釘セミナー～下腿のアドバンスコース～, Nov. 2018, Japanese, Domestic conference偽関節になる経緯と、その後の治療[Invited]Public discourse
- Lower Extremities Trauma Seminar in 博多, Nov. 2018, Japanese, Domestic conference偽関節症例から大腿骨骨幹部骨折を考える[Invited]Public discourse
- 第33回日本整形外科学会基礎学術集会, Oct. 2018, Japanese, Domestic conference炭酸ガス経皮吸収がラットの筋組織に及ぼす影響[Invited]Nominated symposium
- 第13回神戸整形外科セミナー Basic, Aug. 2018, Japanese, Domestic conference創外固定の基礎[Invited]Public discourse
- 第1回炭酸ガス研究会運動器分科会, Jul. 2018, Japanese, Domestic conference炭酸ガス経皮吸収が筋肉に及ぼす影響[Invited]Public discourse
- 第44回日本骨折治療学会, Jul. 2018, Japanese, Domestic conference日本人におけるReamerirrigatoraspirator(RIA)の使用経験Oral presentation
- The 17th Congress of the Japanese Society for Regenerative Medicine, Mar. 2018, Japanese, The Japanese Society for Regenerative Medicine, 横浜, Domestic conference難治性骨折患者を対象とした自家末梢血CD34陽性細胞移植療法 ―医師主導治験の経験からー[Invited]Public symposium
- The 17th Congress of the Japanese Society for Regenerative Medicine, Mar. 2018, Japanese, The Japanese Society for Regenerative Medicine, 横浜, Domestic conference骨延長術における炭酸ガス経皮吸収の骨形成促進効果について[Invited]Poster presentation
- 第451回整形外科集談会京阪神地方会, Feb. 2018, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 大阪, 【はじめに】上腕骨骨幹部骨折治療後の偽関節の発生は10‐20％と報告があり、上腕骨骨幹部偽関節の治療法については自家骨移植と圧迫プレート固定が一般的とされている。今回われわれは上腕骨骨幹部骨折術後の偽関節に対しMIPO法にて手術を行い、骨癒合が得られた2症例について報告する。【症例1】17歳女性。2012年X月、交通事故で左上腕骨骨幹部骨折(AO分類12-B2)を受傷。近医にて髄内釘固定を受けた。術後1年の時点で骨癒合が得られず偽関節として当院紹介となった。治療は髄内釘抜去後にSynthes社製LCP narrow plateを用いて前方進入のMIPO法で固定術を行った。骨癒合が得られ、術後1年で抜釘術を施行した。術後4年現在可動域制限や疼痛はなくADLに支障はない。【症例2】75歳女性。2014年X月、転倒し右上腕骨骨幹部骨折(AO分類12-A3), Domestic conference上腕骨骨幹部偽関節術後偽関節に対してMIPO法にて治療した2例[Invited]Oral presentation
- The 21th The Japanese Research Society of Ultrasound Stimultion for Fracuture Repair, Jan. 2018, Japanese, The Japanese Research Society of Ultrasound Stimulation for Fracture Repair, 東京, [Objective]To obtain a therapeutic effect, appropriate use of low-intensity pulsed ultrasound (LIPUS) is necessary and patient compliance is very important for that. We reported at this meeting in 2014 that explanation for patients using leaflets was usef, Domestic conferenceImproving Patient Compliance with Low-Intensity Pulsed Ultrasound (LIPUS) Treatment (Second Report)[Invited]Oral presentation
- 若手整形外科のための大腿骨髄内釘セミナー －Distal Target Deviceの有用性－, Nov. 2017, Japanese, Stryker Japan, 神戸, Domestic conference各ネイルの特徴、DTD使用時の注意点Oral presentation
- The 19th Annual Meeting of Japan Osteoporosis Society, Oct. 2017, Japanese, Japan Osteoporosis Society, 大阪, Domestic conference大腿骨近位部骨折を起こした高齢者におけるビタミンD充足度の調査[Invited]Oral presentation
- The 32nd Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2017, Japanese, The Japanese Orthopaedic Association, 沖縄（宜野湾）, 目的】microRNA (miRNA)は約22塩基長のnon-coding RNAであり、様々な疾患へ関与しており、近年では骨折治癒過程に与える影響も報告されている。糖尿病は骨折治癒を遷延させることが知られているが、その機序におけるmiRNAの関与は明らかではない。我々は糖尿病におけるmiRNAの発現の健常との差異が骨折治癒遷延に関与していると仮説を立て、1型糖尿病ラットの骨折モデルを用いてmiRNAの網羅的解析を行い、その発現様式を検討した。【方法】Streptozotocinを腹腔内投与し1型糖尿病を発症させたSDラット（DM群）と、健常ラット（対照群）を用い、大腿骨閉鎖性骨折モデルを作製した。骨折後5日目および11日目に骨折部から採取したmiRNAに対し、マイクロアレイ解析を行い、対照群に対しDM群で発現の高いmiRNAを、両日につき上位4種ず, Domestic conferenceAltered Expression of MicroRNAs during Fracture Healing in Diabetic Rats[Invited]Poster presentation
- The 9th AMEC Research Seminar, Oct. 2017, Japanese, Advance Medical Engineering Center , Graduate School of Engineering University of Hyogo, 神戸, Domestic conference骨折治癒の非破壊的評価法についてOral presentation
- The 129ｔｈ Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Oct. 2017, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 富山, 【はじめに】骨形成不全症は骨脆弱性のため骨折を起こしやすい結合組織の遺伝的な障害である。骨質が乏しいため骨折を生じやすく、また、治療に難渋し偽関節となることが多い。我々は骨形成不全症患者の上腕骨骨幹部偽関節に対し下顎骨用locking plateを用いて骨癒合が得られた症例を経験したので報告する。【症例】骨形成不全症III型の30歳男性。1996年に右上腕骨矯正骨切り術を受けた。2010年に右上腕に疼痛の増強を感じ、X線でK-wireの折損と右上腕骨骨幹部に偽関節を認めた。2011年に当院紹介されエンダー釘による内固定と自家骨移植を行った。しかし、その後も骨癒合が得られず術後2年でエンダー釘が折損し疼痛と可動域制限を生じた。2014年に骨幹部内側に下顎骨用locking plateを用い内固定を行った。半年後、骨癒合が得られ日常生活に支障がない可動域, Domestic conference骨形成不全症に合併した上腕骨骨幹部偽関節に対して下顎骨用locking plateを用いて治療した1例[Invited]Oral presentation
- The 32nd Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2017, Japanese, The Japanese Orthopaedic Association, 沖縄（宜野湾）, 【目的】骨腫瘍，骨髄炎，外傷などの治療で骨欠損が生じることがあるが，骨欠損に対して臨床応用可能な治療法の選択肢は限られている．我々は以前，ラット骨折モデルにおいてCO₂経皮吸収が血流促進を介して骨癒合を促進することを報告した．しかし骨欠損に対するCO₂経皮吸収の効果は明らかでない．本研究の目的は，ラット骨欠損モデルにおけるCO₂経皮吸収による骨形成促進効果を明らかにすることである．【方法】12週齢Fischerラットの大腿骨に創外固定器を装着し，骨幹部に1mmの骨欠損を作製した．CO₂経皮吸収は，ラットの骨欠損肢を剃毛した上でハイドロジェルを塗布し，下半身を密閉した空間に100 % CO₂を充満させて行った．ラットを2群に分け，CO₂群にはCO₂経皮吸収を術翌日より1回20分，週5回行い，control群では空気を投与した．単純X線評価では、術後1,, Domestic conferenceTranscutaneous CO₂ application accelerates bone formation in a rat bone defect modelPublic symposium
- The 36th Annual Meeting of the Japanese Society for Transplantation and Tissue Engineering in Musculoskeletal System, Sep. 2017, Japanese, The Japanese Society for Transplantation and Tissue Engineering in Musculoskeletal System, 京都, 【目的】日々の診療において，骨欠損を来たした症例にしばしば遭遇するが，それに対する臨床応用可能な治療法は限られている．我々は以前，ラット骨折モデルにおいてCO₂経皮吸収が血流促進を介して骨癒合を促進することを報告した．しかし骨欠損に対する効果は明らかではない．本研究の目的は，CO₂経皮吸収がラット骨欠損モデルにおいても骨形成促進効果を認めるかどうかを検討することである．【方法】12週齢Fischerラットの大腿骨に創外固定器を装着，骨幹部に1mmの骨欠損を作製した．骨欠損肢を剃毛しハイドロジェルを塗布，下半身を密閉した空間に100 % CO₂を充満させ経皮吸収を行った．CO₂群には術翌日から1回20分，週5回CO₂経皮吸収を行い，control群には空気を投与した．術後1, 2, 3, 4週でX線撮影し，側面像で骨片間にgapがない，あるいは両皮質骨, Domestic conferenceTranscutaneous CO₂ application accelerates bone formation in a rat bone defect modelOral presentation
- The 43nd Annual Meeting of the Japanese Society for Fracture Repair, Jul. 2017, Japanese, Japanese Society for Fracture Repair, 福島, Topical cutaneous application of carbon dioxide using a hydrogel is a new treatment option to accelerate fracture repair -Results of a clinical trial-, Domestic conference炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる－臨床試験の報告－[Invited]Oral presentation
- The 43nd Annual Meeting of the Japanese Society for Fracture Repair, Jul. 2017, Japanese, Japanese Society for Fracture Repair, 福島, Domestic conferenceAnalysis of cases where LIPUS was used following nonunion surgery[Invited]Oral presentation
- Proceedings of the Fuzzy System Symposium, 2015, Japanese, Japan Society for Fuzzy Theory and Intelligent Informatics, A pelvic belt is a tool of first aid for the pelvic fracture patients . The purpose is to stabilize the unstable pelvis and to control bleeding from arteries and organs inside the pelvis . However, there is no pelvic belt which takes into account for the differences of race and gender, and evaluation during surgery . The purpose of this study is to develop an evaluation system for the pelvic belt and worn to be a person. It will be a basis for the future development of the pelvic band. Especially the pelvic band has a risk of decubitus where the pelvic band fixes the major trochanter strongly. Naturally, load generated between the body and pelvic belt is large, because it is required to fix the pelvic fracture. Therefore, we evaluate the distribution and load generated between the body and pelvis belt .An Evaluation of Force Difference Between Left and Right Difference Around Greater Trochanter Under Pelvic Belt.
- JAPANESE SOCIETY FOR MUSCULOSKELETAL MEDICINE
- JAPANESE HIP SOCIETY
- The Journal of Japan Osteoporosis Scociety
- THE JAPANESE ASSOCIATION OF REHABILITATION MEDICINE
- The Central Japan Association of Orthopaedic Surgery and Traumatology
- JAPANESE SOCIETY FOR FRACTURE REPAIR
- THE JAPANESE ORTHOPAEDIC ASSOCIATION
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, Apr. 2021 - Mar. 2025炭酸ガスを利用したロコモティブシンドロームに対する新たな予防・治療法の開発加齢に伴い骨粗鬆症と骨脆弱性骨折のリスクは増大する。これは閉経後の女性で顕著であり、現在骨粗鬆症に対しては薬物治療が一般的である。我々はこれまでに炭酸ガス経皮吸収が、局所組織内の酸素化、血流増加、血管新生を介し、骨折治癒の促進や破骨細胞活性の抑制効果を有する事を報告してきた。本研究の目的の一つは、卵巣摘出（OVX）ラット骨粗鬆症モデルを用いて、炭酸ガス経皮吸収システムにより骨粗鬆症の病態が改善するかを検討する事である。 12週齢の雌ラットを用い、両側OVXを施行し骨粗鬆症モデルを作成した。これらを炭酸ガス経皮吸収群、対照群の二群に分け、炭酸ガス群に対してはOVX術後翌日より炭酸ガス投与を開始する実験系（骨粗鬆症の予防を検討）と、OVX術後8週経過してから炭酸ガス投与を開始する実験系（骨粗鬆症の治療を検討）の二通りの実験系を組んだ。炭酸ガス経皮吸収は1日20分間、週5日行った。対照群に対しては同様のゲルを塗布しポリエチレン袋にて密閉するのみとした。両群において、炭酸ガス経皮吸収開始後8週マイクロCTを用いて大腿骨遠位部の骨量などのパラメータを比較した。現在、各実験系の各群において5サンプルずつの介入が終了し評価を行ったが両群間に有意差は認めていない。 また、今後の研究に密接に関わってくると考えられることから、炭酸ガス経皮吸収の至適治療時間についての検討も行っている。ラット大腿骨骨折モデルを作成し、従来の20分投与に加え、60分投与の群を設定した。頻度は上記と同じく週5日としている。骨折作成後4週までの毎週のレントゲン撮影を終了しており、順次データ解析予定である。また、同様のタイムポイントでの組織評価用のサンプル採取を完了しており、切片作製予定である。さらに、術後2・3週での骨遺伝子学的検討と免疫組織学的検討を行うためのサンプル採取と、術後4週での骨密度評価を行う予定としている。
- 日本学術振興会, 基盤研究（C）, 神戸大学, Apr. 2022 - Mar. 2024, Coinvestigator自家組織を犠牲にしない新規骨再生療法の開発
- 一般社団法人 JA共済総合研究所, JA共済 交通事故医療研究助成, Apr. 2021 - Mar. 2023, Coinvestigator外傷後のリハビリテーションを促進する炭酸ガス経皮吸収療法の実用化に向けた研究
- 一般社団法人 JA共済総合研究所, JA共済 交通事故医療研究助成, 神戸大学医学部附属病院, Apr. 2021 - Mar. 2022, Principal investigator偽関節における骨SPECT(Single Photon Emission Computed Tomography)を用いた定量評価
- 学術研究助成基金助成金／基盤研究(C), Apr. 2017 - Mar. 2019骨折治癒に不利な条件下における、炭酸ガス経皮吸収の骨折治癒促進効果の検討Competitive research funding
- 学術研究助成基金助成金／基盤研究(C), Apr. 2017 - Mar. 2019骨再生療法への炭酸ガスの応用Competitive research funding
- 学術研究助成基金助成金／基盤研究(C), Apr. 2015 - Mar. 2018, Principal investigatorCompetitive research funding
- 日本損害保険協会, Apr. 2012 - Mar. 2013, Principal investigator不安定型骨盤骨折に対する創外固定法の比較と固定位置シミュレーターの開発Competitive research funding
- 二酸化炭素を有効成分とする骨折治療剤、骨成長促進剤または骨疾患治療若しくは予防剤特願2015-002766, 09 Jan. 2015, ネオケミア株式会社, CO2BE MEDICAL ENGINEERING株式会社, 国立大学法人神戸大学, 特開2015-107987, 11 Jun. 2015Patent right
- 二酸化炭素を有効成分とする骨折治療剤、骨成長促進剤または骨疾患治療若しくは予防剤特願2013-524701, 13 Jul. 2012, ネオケミア株式会社, CO2BE MEDICAL ENGINEERING株式会社, 国立大学法人神戸大学, 特許第5747189号, 22 May 2015Patent right
- 二酸化炭素を有効成分とする骨折治療剤、骨成長促進剤または骨疾患治療若しくは予防剤JP2012067905, 13 Jul. 2012, ネオケミア株式会社, CO2BE MEDICAL ENGINEERING株式会社, 国立大学法人神戸大学, WO2013-011935, 24 Jan. 2013Patent right