Research activity information

• Jun. 2025 第51回日本整形外傷学会, 学会賞, 後肢懸垂ラットの骨折モデルにおける 炭酸ガス経皮吸収療法の効果の検討

  近藤 飛馬, 福井友章, 大江啓介, 隈部洋平, 福本弦太, 西田亮太, 山本裕也, 黒田良祐


• Jun. 2024 第50回日本骨折治療学会学術集会, 学会賞, 骨折関連感染症治療の有効性に 持続局所抗菌薬潅流（CLAP）が及ぼす影響 ー多施設研究ー

  高原俊介、善家雄吉、姫野大輔、山下伸之輔、松本匡洋、山川泰明、森井北斗、大江啓介、新倉隆宏、圓尾明弘


• Jun. 2023 第46回日本骨・関節感染症学会, 最優秀演題賞, 高濃度抗菌薬が骨髄由来細胞の増殖能および分化能に与える影響

  山本裕也、大江啓介、福井友章、澤内健一、吉川遼、高瀬恭平、西田亮太、新倉隆宏、圓尾明弘、黒田良祐


• Jun. 2019 第45回日本骨折治療学会学術集会, 学会賞, 解剖用屍体におけるiMAPから髄内に投与された抗菌薬の薬物動態の検討

  圓尾明弘、福井友章、大江啓介、新倉隆宏、善家雄吉


• Nov. 2018 第16回 ORS ISFR Biennial Workshop, Best case report award

  澤内健一、大江 啓介、福井友章、新倉隆宏、黒田良祐


• Nov. 2018 第16回 ORS ISFR Biennial Workshop, Best presentation award

  新倉隆宏、大江 啓介、福井友章、黒田良祐


• Mar. 2008 the 37th Conference of the Japanese Society of Oral Implantology, Best Poster Award

  OE Keisuke

• Simultaneous Bilateral Methicillin-Resistant Staphylococcus aureus Infection After Total Knee Arthroplasty Successfully Treated with Continuous Local Antibiotic Perfusion: A Case Report.

  Kohei Motono, Tomoyuki Matsumoto, Keisuke Oe, Masanori Tsubosaka, Naoki Nakano, Tomoaki Fukui, Yohei Kumabe, Ryosuke Kuroda

  BACKGROUND Continuous local antibiotic perfusion (CLAP) delivers gentamicin continuously via a bone marrow needle and double-lumen tube in the infected area, taking advantage of the concentration-dependent bactericidal activity of gentamicin, and allowing even resistant bacteria to be inhibited at high local concentrations. CLAP has shown good outcomes in bone and soft-tissue infections. However, reports on its use for periprosthetic joint infection (PJI) after total knee arthroplasty are limited. Moreover, bilateral simultaneous methicillin-resistant Staphylococcus aureus (MRSA) infection following total knee arthroplasty is rare. We report the successful CLAP treatment of simultaneous bilateral MRSA infection after total knee arthroplasty. CASE REPORT A 69-year-old man with cerebral palsy presented with a 2-week history of gait difficulty and 3-day history of fever. At 12 and 9 months before presentation, he underwent left and right total knee arthroplasty, respectively. Both knees showed swelling, pain, and redness. The leukocyte count was 12 820/μL, and C-reactive protein level was 16.27 mg/dL. Bilateral aspiration revealed gram-positive cocci, confirming PJI, without implant loosening. We performed simultaneous debridement, irrigation, insert exchange, and CLAP on both knees. Intraoperative joint fluid cultures showed MRSA. Gentamicin was given intra-articularly for 14 days alongside intravenous vancomycin, which was continued for 31 days before switching to oral minocycline for 6 months. One year after surgery, the white blood cell count was 3400/µL, the C-reactive protein level was 0.08 mg/dL, and the range of motion was 0 to 130 degrees, with no recurrence of PJI. CONCLUSIONS CLAP represents a viable treatment option for PJI caused by MRSA after total knee arthroplasty.

  Oct. 2025, The American journal of case reports, 26, e949779, English, International magazine

  Scientific journal


• Salvage Masquelet Technique for Insufficient Bone Regeneration Following Chipping and Lengthening in Tibial Nonunion: A Case Report.

  Jun Takagaki, Yohei Kumabe, Tomoaki Fukui, Ryosuke Kuroda, Keisuke Oe

  BACKGROUND The treatment of nonunion with deformity and shortening remains a significant challenge in orthopedic surgery. The chipping and lengthening technique is used for bone reconstruction and new bone formation, without the need for bone grafting. However, inadequate bone regeneration can require additional treatment. The Masquelet technique, a 2-stage procedure involving an induced membrane, has been reported to be effective in managing large bone defects and nonunion cases. CASE REPORT We present a case of a 21-year-old man with tibial nonunion associated with deformity and shortening. The patient underwent the chipping and lengthening technique using an external fixator, followed by conversion to internal fixation. However, bone regeneration at the distraction site was insufficient, necessitating salvage surgery using the Masquelet technique. The first-stage procedure involved debridement of the immature regenerate and placement of a cement spacer to induce membrane formation. In the second stage, the cement spacer was removed and replaced with an autologous bone graft. As a result, successful bone union was achieved, enabling the patient to regain full weight-bearing ability without complications. CONCLUSIONS This case highlights the effectiveness of the Masquelet technique as a salvage procedure for inadequate bone regeneration following the chipping and lengthening technique. The combination of these techniques is a viable treatment approach for nonunion cases with deformity and shortening.

  Sep. 2025, The American journal of case reports, 26, e948871, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Investigation of 222-nm ultraviolet C irradiation bactericidal effect on the surgical field in a rabbit model.

  Tomoaki Fukui, Yuya Yamamoto, Kyohei Takase, Keisuke Oe, Kenichi Sawauchi, Ryota Nishida, Takahiro Niikura, Rena Kaigome, Masahiro Sasaki, Toru Koi, Hiroyuki Ohashi, Ryosuke Kuroda

  Ultraviolet C (UV-C) not only has a bactericidal effect, but is also cytotoxic; however, UV-C at a wavelength of 222 nm with a high absorption coefficient for proteins is considered safe. We have previously reported the safety of 222-nm UV-C irradiation in humans and rabbits. This study evaluated the bactericidal effect of 222-nm UV-C irradiation on exposed surgical fields. Sixteen-week-old female rabbits were used, and the exposed area on their backs was sprayed with a bacterial solution from swabs collected from their soles. Three groups were formed based on UV-C irradiation: 500 mJ/cm2 of 222-nm UV-C, 200 mJ/cm2 of 254-nm UV-C, which is commonly used in germicidal lamps, and non-UV-C irradiation. The bacterial colonies were counted after irradiation. Both UV-C groups showed a significant reduction in bacterial colonies compared to the nonirradiated group, with no significant difference between the two UV-C groups. Microbiota analysis identified species that could cause surgical site infections. The results of the study suggest that 500 mJ/cm2 of 222-nm UV-C irradiation effectively reduces bacterial load, with a bactericidal effect comparable to 254-nm UV-C; hence, 222-nm UV-C irradiation is a promising and safe tool for minimizing the risk of surgical site infections.

  Sep. 2025, Photochemistry and photobiology, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effectiveness of rehabilitation treatment for bone metastasis patients without surgical intervention: A propensity score matching analysis.

  Ryo Yoshikawa, Yasumitsu Fujii, Ryoga Kashima, Wataru Saho, Risa Harada, Daisuke Makiura, Katsuya Fujiwara, Junichiro Inoue, Yoshiki Takeoka, Ryoko Sawada, Naomasa Fukase, Keisuke Oe, Hitomi Hara, Kenichiro Kakutani, Toshihiro Akisue, Yoshitada Sakai

  Evidence regarding the effectiveness of rehabilitation treatments in patients with bone metastases remains limited. This study evaluated the implementation and effectiveness of rehabilitation in patients with bone metastases who did not undergo surgery. This retrospective study included 200 patients with nonsurgically treated bone metastases at our institution. The patients were categorized into a rehabilitation group (R group, n = 61) and a non-rehabilitation group (N group, n = 139). Over the course of one month, we compared activities of daily living (ADL), assessed using the Barthel Index (BI), quality of life (QOL), measured using the EuroQoL-5 Dimension (EQ-5D), and demographic and clinical characteristics. Propensity score matching was conducted to minimize selection bias. After matching, 31 patients in each group were included in the analysis. No statistically significant differences were observed in baseline BI and EQ-5D scores between the two groups. In the R group, BI improved significantly from 80 (interquartile range [IQR]: 60-100) to 90 (IQR: 70-100), and EQ-5D improved from 0.444 (IQR: 0.282-0.608) to 0.608 (IQR: 0.533-0.768). In contrast, no improvements were observed in either score in the N group. Chemotherapy was identified as a significant factor associated with improvements in BI (odds ratio 4.03) and EQ-5D (odds ratio 5.29). Rehabilitation may be a valuable treatment option for nonsurgically treated patients with bone metastases, warranting further validation in prospective studies.

  Aug. 2025, Journal of bone oncology, 53, 100703 - 100703, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Successful Correction of Lower-Limb Malunions Using Intramedullary Nailing and Chipping Osteotomy: A Case Series.

  Ryota Nishida, Tomoaki Fukui, Takahiro Niikura, Yohei Kumabe, Yutaka Matsumiya, Yuya Yamamoto, Hyuma Kondo, Jonathan Jonathan, Genta Fukumoto, Ryosuke Kuroda, Keisuke Oe

  BACKGROUND Lower-limb fracture malunion can result in angular deformity that requires surgical correction. Chipping corrective osteotomy (CCO) is a novel method that involves a chipping technique at the center of rotation of angulation, followed by single-stage internal fixation. This case series describes 3 cases of correction of fracture malunion of the lower limb managed using combined CCO and intramedullary nail stabilization. CASE REPORT Case 1: A 47-year-old man with a 17° varus deformity of the left tibia from a past accident had left knee pain. CCO was performed, achieving bone union in 4 months. The Mikulicz line improved from -11% to 23%, and his knee became pain-free. Case 2: A 59-year-old man with a 19° valgus deformity of the right tibia from a past accident had right knee pain. CCO was performed, achieving bone union in 11 months. The Mikulicz line improved from 119% to 72%, and he could perform daily activities pain-free. Case 3: A 59-year-old man with a complex left distal femoral deformity (25° varus and 15° internal rotation) from a past accident had left knee pain. CCO was performed, achieving bone union in 8 months. The Mikulicz line improved from -52% to 4%, and he started enjoying jogging. CONCLUSIONS We performed CCO combined with intramedullary nail stabilization in 3 cases of post-traumatic angular and rotational malunion, achieving good clinical outcomes. This single-stage surgery is advantageous for bone healing and is cost-effective, making it a viable option for correcting long-bone malunion.

  Jun. 2025, The American journal of case reports, 26, e947845, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Diagnosis of skeletal fragility due to Loeys-Dietz syndrome and treatment with romosozumab followed by denosumab.

  Yasutaka Tsujimoto, Naoki Yamamoto, Hayato Fukumitsu, Hironori Bando, Masaaki Yamamoto, Keiko Tanaka, Naoya Morisada, Miwako Nagasaka, Keisuke Oe, Takahiro Niikura, Mika Yamauchi, Wataru Ogawa, Hidenori Fukuoka

  Loeys-Dietz syndrome (LDS) is an autosomal dominant, inherited connective tissue disorder caused by a pathogenic variant in TGF-β signaling-related genes. LDS is associated with a high risk of low bone mineral density (BMD) and fractures. We present a case report of a 43-year-old premenopausal woman with skeletal fragility who was diagnosed with LDS type 4 due to a large heterozygous deletion in the TGFB2 gene. Upon initial referral, she was evaluated for secondary osteoporosis. Although mild abnormalities in calcium metabolism, menstrual irregularities, and lack of exercise were observed, they were not associated with this condition. However, a thorough family history and physical examination raised the suspicion of Marfan syndrome and related disorders, which were subsequently confirmed using genetic testing. Treatment with romosozumab for 1 year increased the lumbar spine BMD from 0.750 g/cm2 (Z-score -2.1) to 0.881 g/cm2 (Z-score -1.0) and the femoral neck BMD from 0.407 g/cm2 (Z-score - 3.0) to 0.428 g/cm2 (Z-score - 2.6), with a slight increase in total hip BMD from 0.525 g/cm2 (Z-score -2.6) to 0.527 g/cm2 (Z-score -2.4). Subsequent therapy with denosumab for 1 year further improved the lumbar spine BMD to 0.939 g/cm2 (Z-score, -0.5), femoral neck BMD to 0.496 g/cm2 (Z-score, -2.0), and total hip BMD to 0.552 g/cm2 (Z-score, -2.2). To our knowledge, this is the first case report of an improvement in BMD with romosozumab, followed by denosumab, for skeletal fragility due to LDS. Our findings suggest that this treatment regimen may be an effective therapeutic option for the management of skeletal fragility in patients with LDS.

  Jun. 2025, Bone reports, 25, 101849 - 101849, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Innovative Management of Brodie's Abscess: Continuous Local Antibiotic Perfusion in a 14-Year-Old Patient.

  Kenichi Sawauchi, Keisuke Oe, Tomoaki Fukui, Yohei Kumabe, Hirotsugu Muratsu, Ryosuke Kuroda, Akihiro Maruo

  BACKGROUND Brodie's abscess is a rare form of subacute osteomyelitis that primarily affects the metaphyseal regions of long bones. Conventional treatment involves thorough curettage and systemic antibiotic therapy for ≥6 weeks, with bone grafting required for abscess sizes >3 cm. Continuous local antibiotic perfusion (CLAP) delivers high concentrations of antibiotics directly to the infection site and facilitates preservation of biologically active bone tissue. Here, we report a case of an extensive Brodie's abscess that was successfully treated with CLAP, highlighting its potential as an alternative to conventional treatment. CASE REPORT A 14-year-old boy was diagnosed with a 15-cm Brodie's abscess in the medial cortical bone of the left femur, with a primary infection in the intracortical pseudocavity. The patient underwent treatment with CLAP and intramedullary antibiotic perfusion pins were placed in the pseudocavity. Given the preservation of bone bioactivity, we anticipated spontaneous bone remodeling after infection control and therefore decided against bone grafting. The infection site received direct gentamicin infusions for 18 days, and systemic antibiotic therapy continued for 1 month. Postoperatively, the signs of inflammation rapidly subsided, and thereafter, no recurrence of infection was observed, while bone remodeling was achieved at the site of the bone defect. CONCLUSIONS In cases of cortical bone abscess, systemically administered antibiotics have limited penetration, whereas CLAP allows direct administration of high-concentration antibiotics to the lesion, which may provide an advantage in infection control. The findings of this case suggest that CLAP may serve as a viable treatment option for Brodie's abscess, particularly in cases with limited systemic antibiotic penetration.

  Mar. 2025, The American journal of case reports, 26, e947099, English, International magazine

  Scientific journal


• Effect of intermittent extracellular low-pH environment on human umbilical vein endothelial cell activity.

  Ryota Nishida, Tomoaki Fukui, Kenichi Sawauchi, Yohei Kumabe, Hyuma Kondo, Yuya Yamamoto, Kyohei Takase, Ryo Yoshikawa, Takahiro Niikura, Ryosuke Kuroda, Keisuke Oe

  Transcutaneous CO2 application promotes fracture healing and osteogenesis via angiogenesis. However, its molecular mechanism remains unclear. This therapy transiently decreases intra-tissue pH in the affected area to approximately 7.0 for 20 min, followed by recovery. We hypothesized that such intermittent pH changes activate endothelial cells similarly to acidic preconditioning. We aimed to investigate the response of human umbilical vein endothelial cells (HUVECs) to daily intermittent low-pH stimulation. HUVECs were cultured under three conditions: daily 20-min exposure to a low-pH medium (approximately 7.0), followed by a return to a control medium (approximately 7.4) (Change group); continuous exposure to a low-pH medium (Low pH group); constant culturing in a control medium (Control group). Cell proliferation, tube formation, migration, and protein/gene expression were assessed. Tube formation and migration were significantly enhanced in the Change group compared with those in the Control group, and tube formation was also increased in the Low pH group. Western blotting revealed upregulated expression of vascular endothelial growth factor (VEGF) and VEGF receptor 2 in the Change group. CD31 gene expression was elevated in the Low pH and Change groups on Days 1 and 7, respectively. Phosphorylated extracellular signal-regulated kinases 1 and 2 (ERK1/2) and protein kinase B (AKT) levels in the Low pH and Change groups were significantly increased compared with those in the Control, except for ERK2 in the Low pH group. The suppression of ERK1/2 or AKT by their inhibitors (U0126 and LY294002, respectively) during low-pH exposure inhibited proliferation and tube formation, indicating that the ERK1/2 mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K)/AKT pathways mediate endothelial cell activation in response to intermittent acidic stimulation. Intermittent low-pH exposure enhanced HUVEC activity, mediated by the ERK1/2 MAPK and PI3K/AKT pathways. Our findings provide insights into the mechanism by which transcutaneous CO2 application promotes angiogenesis and tissue repair.

  2025, PloS one, 20(9) (9), e0332673, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Evaluating ChatGPT's Performance in Classifying Pertrochanteric Fractures Based on Arbeitsgemeinschaft für Osteosynthesefragen/Orthopedic Trauma Association (AO/OTA) Standards.

  Mitsuaki Noda, Shunsuke Takahara, Shinya Hayashi, Atsuyuki Inui, Keisuke Oe, Takehiko Matsushita

  Introduction Generative Pre-Training Transformer (ChatGPT) has become widely recognized for its capability to generate text, synthesize complex information, and perform a variety of tasks without requiring human specialists for data collection. The latest iteration, ChatGPT-4, is a large multimodal model capable of integrating both text and image inputs, rendering it particularly promising for medical applications. However, its efficacy in analyzing radiographic images remains largely unexplored. Aim This study aims to (i) address the lack of data on the accuracy of ChatGPT in radiographic fracture classification into stable or unstable under the revised Arbeitsgemeinschaft für Osteosynthesefragen/Orthopedic Trauma Association (AO/OTA) classification system, and this procedure is also performed by surgeons, and (ii) compare the agreement between surgeons or ChatGPT-based performance. The study hypothesizes that the use of ChatGPT would achieve moderate agreement with orthopedic surgeons. Materials and methods Patients diagnosed with pertrochanteric fractures were retrospectively collected. Patients with both preoperative two-directional plain radiographs and CT scans (3D-CT) images were conditioned for enrollment into the study. Two orthopedic surgeons (observer 1 and observer 2, respectively) and one resident (observer 3) were once assigned to dichotomized groups into A1 (stable) or A2 (unstable) based on AO/OTA classification using two-directional plain radiographs. Prior to the ChatGPT study, all the anteroposterior images trimmed at the fractured side, attached with figure names including gender, and age, were inputted into OpenAI ChatGPT-4. Radiological evaluation prompts were designed to initiate ChatGPT's classification analysis of the uploaded radiographic images. A single observer (MN) decided the classification patterns by examining 3D CT scan images as well as plain radiographs. This judgment of A1 (stable) and A2 (unstable) was set as a benchmark to mark the results of observers and ChatGPT based on plain radiographs. Results The cohort consisted of 29 males and 90 females, with a mean age of 87 years after the data exclusion. The fractures were classified into A1 (stable) and A2 (unstable) groups based on CT imaging. The A1 group included 50 patients (13 males, 37 females; mean age: 86.2 ± 7.8 years), while the A2 group included 69 patients (16 males, 53 females; mean age: 87.0 ± 7.9 years). Kappa values for fracture classification between plain radiographs evaluated by the three observers and ChatGPT, compared to the CT-based gold standard, showed fair to moderate agreement: Observer 1: 0.494 (95% CI: 0.337-0.650), Observer 2: 0.390 (95% CI: 0.227-0.553), Observer 3: 0.360 (95% CI: 0.198-0.521), and ChatGPT: 0.420 (95% CI: 0.255-0.585). ChatGPT demonstrated accuracy, sensitivity, specificity, and positive and negative predictable values comparable to the human observers, suggesting moderate reliability. Conclusion This study demonstrates that ChatGPT can classify pertrochanteric fractures into A1 (stable) and A2 (unstable) under the Revised AO/OTA Classification System. Its moderate agreement with CT-based assessments (κ = 0.420) is comparable to the performance of orthopedic surgeons. Moreover, ChatGPT is straightforward to integrate into clinical workflows, requiring minimal data collection for training.

  Jan. 2025, Cureus, 17(1) (1), e78068, English, International magazine

  Scientific journal


• Preventive effects of transcutaneous CO2 application on disuse osteoporosis and muscle atrophy in a rat hindlimb suspension model.

  Ryota Nishida, Tomoaki Fukui, Takahiro Niikura, Yohei Kumabe, Ryo Yoshikawa, Kyohei Takase, Yuya Yamamoto, Ryosuke Kuroda, Keisuke Oe

  We previously demonstrated that transcutaneous CO2 application promotes muscle fiber-type switching, fracture healing, and osteogenesis by increasing blood flow and angiogenesis. Here, we aimed to investigate the preventive effects of transcutaneous CO2 application on disuse osteoporosis and muscle atrophy in a rat hindlimb suspension model. Eleven-week-old male Sprague-Dawley rats were divided into hindlimb suspension (HS), HS with transcutaneous CO2 application (HSCO2), and control groups. HSCO2 rats were administered transcutaneous 100 % CO2 gas in their bilateral hindlimbs, five times a week for 20 min. After 3 weeks, we harvested the gastrocnemius, femur, and tibia for assessment. Histological analysis revealed a significant decrease in the gastrocnemius myofiber cross-sectional area in HS rats compared to the control rats, whereas HSCO2 rats exhibited a significant increase compared to HS rats. Micro-computed tomography showed significant bone atrophy in the trabecular and cortical bones of the femur in HS rats compared to those of the control rats, whereas significant improvement was noted in HSCO2 rats. Histological analysis of the proximal tibia revealed more marrow adipose tissue in the HS rats than in the control rats. However, in the HSCO2 rats, fewer marrow adipose tissue and osteoclasts were observed. Moreover, HSCO2 rats had more osteoblasts and higher expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and vascular endothelial growth factor (VEGF) than the HS rats. The gastrocnemius and distal femur of HSCO2 rats also exhibited elevated PGC-1α and VEGF expression and upregulation of the myogenesis markers and osteogenesis markers compared to those of HS rats. This treatment effectively prevented disuse osteoporosis and muscle atrophy by promoting local angiogenesis and blood flow. PGC-1α is crucial for promoting this angiogenic pathway. Transcutaneous CO2 application may be a novel preventive procedure for disuse osteoporosis and muscle atrophy, complementing medication and rehabilitation.

  Dec. 2024, Bone, 189, 117262 - 117262, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Transcutaneous CO2 application combined with low-intensity pulsed ultrasound accelerates bone fracture healing in rats.

  Kenichi Sawauchi, Tomoaki Fukui, Keisuke Oe, Takahiro Oda, Ryo Yoshikawa, Kyohei Takase, Shota Inoue, Ryota Nishida, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Low-intensity pulsed ultrasound (LIPUS) is a non-invasive therapy that accelerates fracture healing. As a new treatment method for fracture, we recently reported that the transcutaneous application of CO2 accelerated fracture healing in association with promoting angiogenesis, blood flow, and endochondral ossification. We hypothesized that transcutaneous CO2 application, combined with LIPUS, would promote bone fracture healing more than the single treatment with either of them. METHODS: Femoral shaft fractures were produced in 12-week-old rats. Animals were randomly divided into four groups: the combination of CO2 and LIPUS, CO2, LIPUS, and control groups. As the transcutaneous CO2 application, the limb was sealed in a CO2-filled bag after applying hydrogel that promotes CO2 absorption. Transcutaneous CO2 application and LIPUS irradiation were performed for 20 min/day, 5 days/week. At weeks 1, 2, 3, and 4 after the fractures, we assessed the fracture healing process using radiography, histology, immunohistochemistry, real-time PCR, and biomechanical assessment. RESULTS: The fracture healing score using radiographs in the combination group was significantly higher than that in the control group at all time points and those in both the LIPUS and CO2 groups at weeks 1, 2, and 4. The degree of bone fracture healing in the histological assessment was significantly higher in the combination group than that in the control group at weeks 2, 3, and 4. In the immunohistochemical assessment, the vascular densities of CD31- and endomucin-positive microvessels in the combination group were significantly higher than those in the control and LIPUS groups at week 2. In the gene expression assessment, significant upregulation of runt-related transcription factor 2 (Runx2) and vascular endothelial growth factor (VEGF) was detected in the combination group compared to the LIPUS and CO2 monotherapy groups. In the biomechanical assessment, the ultimate stress was significantly higher in the combination group than in the LIPUS and CO2 groups. CONCLUSION: The combination therapy of transcutaneous CO2 application and LIPUS had a superior effect in promoting fracture healing through the promotion of angiogenesis and osteoblast differentiation compared to monotherapy.

  Oct. 2024, BMC musculoskeletal disorders, 25(1) (1), 863 - 863, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Does the Instability of Pertrochanteric Fractures in the Elderly Correlate With Weakened Gluteal Muscles?

  Mitsuaki Noda, Shunsuke Takahara, Shinya Hayashi, Atsuyuki Inui, Keisuke Oe, Shin Osawa, Takehiko Matsushita

  Introduction Suboptimal outcomes were observed in cases of unstable pertrochanteric fractures, even when bone healing occurs without complications. This raises the question of whether factors beyond bone health integrity, such as the frailty of muscles, contribute to these less favorable results. Muscles, particularly the gluteal muscles, not only influence functional ability but also serve as a cushion that provides physical protection against external forces during falls. When gluteal muscles are thin or weak, their ability to absorb the impact from a fall diminishes, potentially leading to unstable fractures. In this study, we compared gluteal muscle-related indices, including cross-sectional area (CSA) and muscle density, between stable and unstable pertrochanteric fractures. The aim of this study was to employ a retrospective approach to investigate the causes of unstable fractures, with a focus on potential muscular pathology. It was hypothesized that reduced CSA and lower density of the gluteal muscles would be associated with unstable fractures. Material and methods Geriatric patients aged 70 years or older with pertrochanteric fractures requiring surgical intervention were retrospectively identified from databases. These fractures classified as stable (A1) or unstable (A2) based on the Revised Arbeitsgemeinschaft für Osteosynthesefragen (AO)/Orthopaedic Trauma Association (OTA) Classification were compared based on demographic variables (age, height, body mass index (BMI), and fracture laterality) as well as muscle-related indices. A multivariate logistic regression model was employed to identify predictors of unstable fractures. Independent variables included age at the time of surgery, height, BMI, and muscular metrics CSA and density of the gluteus maximus and gluteus medius. Results Out of 220 patients identified from the database, 111 patients with an average age of 88 years (ranging from 71 to 103 years) were included. This cohort consisted of 40 patients with stable fractures (A1) and 71 patients with unstable fractures (A2). Among the demographical data, only fracture laterality demonstrated a significant difference between the groups (p < 0.05). Regarding gluteal muscle data, the CSA/BMI of both the gluteus maximus and medius, as well as the density of the gluteus medius, did not show significant differences between the two groups. The only exception was the density of the gluteus maximus, which was significantly lower in the unstable group (p < 0.01). A binary logistic regression analysis was conducted to identify risk factors for unstable fractures. The analysis found that the density of the gluteus maximus was a statistically significant predictor, with an odds ratio of 0.959 (95% CI, 0.923 to 0.997; p = 0.03). To determine an optimal cut-off value, receiver operating characteristic (ROC) analysis was performed for the density of the gluteus maximus. The Youden index identified a cut-off value of 20.8 HU for the gluteus maximus density as the optimal threshold (area under the curve (AUC): 0.625; 95% CI: 0.520-0.730). Conclusion This retrospective study investigated whether unstable pertrochanteric fractures in elderly female patients were linked to weakened gluteal muscles, compared to stable fractures, and suggested this muscle weakness may contribute to poor functional outcomes. Our binary regression analysis indicated that decreased muscle density in the gluteus maximus increases the risk of unstable fractures.

  Oct. 2024, Cureus, 16(10) (10), e72159, English, International magazine

  Scientific journal


• Management of Infected Tibial Nonunion: Combining Synthetic Bone Grafting with Continuous Local Antibiotic Perfusion (CLAP).

  Kenichi Sawauchi, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Takahiro Niikura, Hirotsugu Muratsu, Akihiro Maruo

  BACKGROUND Infection control and reconstruction of bone and soft tissue are essential for treating infected nonunion. Continuous local antibiotic perfusion (CLAP) is a drug delivery system that continuously delivers antibiotics at the required concentration, area, and duration. This case report describes the instance of infected nonunion in which infection eradication and bone union were achieved using CLAP and synthetic bone grafting while retaining the implant. CASE REPORT The case was a 31-year-old woman with an infected nonunion. After she underwent osteosynthesis using nail for open fractures of tibia and fibula, bone union remained unachieved, and she exhibited skin defects and draining of pus. Following the removal of the infected granulation tissue from the bone defects, 2 bone marrow needles, serving as intramedullary antibiotic perfusion (iMAP) pins, were inserted into the medullary cavity tibia. A double-lumen tube was placed in the subcutaneous pocket as the intra-soft tissue antibiotic perfusion (iSAP) tube. No bone mobility was observed around the bone defect and nail, and replacement of the implant was not necessary. Beta-tricalcium phosphate was transplanted to the bone defect, and negative pressure wound therapy was applied. Gentamicin was injected continuously through iMAP and iSAP. Finally, the infection was eradicated, and cortical bone bridging was observed without additional surgery or adverse effects. CONCLUSIONS CLAP emerges as a viable treatment option for infected nonunion, as it enables the delivery of antibiotics at a concentration sufficient for infection control while providing the surgeon with flexibility to design the area, dosage, and duration of antibiotic delivery.

  Sep. 2024, The American journal of case reports, 25, e945023, English, International magazine

  Scientific journal


• Three-dimensional printed calcium phosphate scaffolds emulate bone microstructure to promote bone regrowth and repair.

  Kyohei Takase, Takahiro Niikura, Tomoaki Fukui, Yohei Kumabe, Kenichi Sawauchi, Ryo Yoshikawa, Yuya Yamamoto, Ryota Nishida, Tomoyuki Matsumoto, Ryosuke Kuroda, Keisuke Oe

  The interconnected structures in a 3D scaffold allows the movement of cells and nutrients. Therefore, this study aimed to investigate the in-vivo bioactivity of 3D-printed β-tricalcium phosphate (β-TCP) and hydroxyapatite (HAP) scaffolds that replicate biological bone. This study included 24-week-old male New Zealand white rabbits. A cylindrical bone defect with a diameter of 4.5 mm and a depth of 8 mm was created in the lateral aspect of the distal femur. A 3D-printed scaffold was implanted in the right femur (experimental side), whereas the left femur was kept free of implantation (control side). Micro-CT analysis and histological observations of the bone defect site were conducted at 4, 8, and 12 weeks postoperatively to track the bone repair progress. No evidence of new bone tissue formation was found in the medullary cavity of the bone defect on the control side. In contrast, on the experimental side, the 3D scaffold demonstrated sufficient bioactivity, leading to the growth of new bone tissue. Over time, new bone tissue gradually extended from the periphery toward the center, a phenomenon evident in both micro-CT images and biopsy staining. In the current study, we observed that the cells involved in bone metabolism adhered, spread, and proliferated on our newly designed 3D-printed scaffold with a bone microstructure. Therefore, it is suggested that this scaffold has sufficient bioactivity to induce new bone formation and could be expected to be a more useful artificial bone than the existing version.

  Sep. 2024, Journal of materials science. Materials in medicine, 35(1) (1), 53 - 53, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Perioperative surveillance of myocardial injury after non-cardiac surgery in patients with hip fracture: A retrospective cohort study.

  Naoto Ishimaru, Takahiro Waki, Toshio Shimokawa, Shimpei Mizuki, Jun Ohnishi, Yohei Kanzawa, Takahiro Nakajima, Tomonori Yano, Kenjiro Ito, Keisuke Oe, Saori Kinami

  Myocardial injury after non-cardiac surgery is due to ischaemia either during non-cardiac surgery or within 30 days after it. Our surveillance protocol includes hip fracture template and high-sensitivity troponin stratification, as recommended in European countries. Our retrospective study cohort included surgical patients for hip fracture at our hospital in Japan. The primary outcome was the rate of myocardial injury after non-cardiac surgery in comparison to patients managed with (213) and without (176) hip fracture template. The hip fracture template was used more in patients with myocardial injury after non-cardiac surgery than those without myocardial injury after non-cardiac surgery. When hip fracture template was used, patients had a higher likelihood of myocardial injury after non-cardiac surgery after adjusting for age, time to operation, diabetes mellitus, and chronic kidney disease (odds ratio 41.3; 95% confidence interval: 12.1, 259.6). Patients with myocardial injury after non-cardiac surgery had higher in-hospital mortality than those without myocardial injury after non-cardiac surgery, even in adjusted analysis. There was a high detection rate of myocardial injury after non-cardiac surgery when patients with hip fractures were managed with hip fracture template. Myocardial injury after non-cardiac surgery was associated with in-hospital mortality.

  Aug. 2024, Journal of perioperative practice, 17504589241268624 - 17504589241268624, English, International magazine

  Scientific journal


• Postoperative Gait Performance Following Pertrochanteric Fractures Is Influenced by the Preoperative Condition of the Gluteal Muscles.

  Mitsuaki Noda, Shunsuke Takahara, Atsuyuki Inui, Keisuke Oe, Shin Osawa, Takehiko Matsushita

  Introduction Amid an increasing number of patients with pertrochanteric fractures, early prediction of postoperative gait potential could reduce unnecessary rehabilitation and hospitalization. The relationship between preoperative gluteal muscle condition and postoperative gait outcomes remains unclear. The gluteal muscles are crucial for mobility, and their cross-sectional area (CSA) and fatty infiltration are indicators of physical function. Preoperative computed tomography (CT) provides quantitative data on muscle CSA and density, measured in Hounsfield Units (HU). This study aimed to identify which preoperative muscle index, CSA, BMI-adjusted CSA, or muscle density, best predicts postoperative gait ability. We hypothesized that a higher adjusted CSA and muscle density in the gluteus muscles would be associated with superior gait performance. Materials and methods Preoperative assessments included radiographs and CT scans. Patients under 75, with less than four weeks of follow-up, prior contralateral hip surgery, prefracture immobility, male patients, high-energy trauma, or conditions impairing physical performance were excluded. Gait performance was evaluated four weeks postoperatively, classifying patients into two groups: the 'parallel bar group,' requiring parallel bars, and the 'walker group,' walking independently. Patients underwent CM nailing. Preoperative CT scans measured the CSA and muscle density of the gluteus maximus and medius. Measurements were taken from the non-injured side to avoid interference from the fracture. Muscle borders were manually traced, and the CSA and muscle density in HU were calculated. Results Out of 81 patients, 49 met the inclusion criteria (mean age: 87). The patients were divided into the 'parallel bar group' (n=19) and the 'walker group' (n=30) based on postoperative gait performance. No significant differences in age, weight, height, or fracture laterality were observed between groups. The mean (and standard deviation (SD)) of CSA for the gluteus maximus in the 'parallel bar group'/in the 'walker group' was 2211.8 ± 469.8 mm²/2440.0 ± 586.2 mm², respectively (p=0.15), and for the gluteus medius, it was 1751.7 ± 415.2mm²/1869.1 ± 448.3mm², respectively (p=0.36). The mean (and SD) muscle density for the gluteus maximus in the 'parallel bar group'/in the 'walker group' was 13.6 ± 12.7 HU / 20.6 ± 13.0 HU (p=0.07), and for the gluteus medius, it was 25.2 ± 8.4 HU/31.8 ± 10.1 HU, respectively (p=0.02). The ROC curve identified a 30.9 HU cut-off for gluteus medius density, with sensitivity and specificity of 60.7% and 78.9%. The mean (and SD) of BMI-adjusted CSA for the gluteus maximus in the 'parallel bar group'/ in the 'walker group' was 116.4 ± 26.8 m²/106 kg/124.3 ± 29.2 m²/106 kg, respectively (p=0.35), and for the gluteus medius, it was 93.3 ± 27.2 m²/106 kg/95.4 ± 21.3m²/106kg, respectively (p=0.78). Conclusion This study analyzed preoperative CT images of women aged 75 and older with pertrochanteric fractures, comparing gluteal muscle CSA and density with postoperative walking ability. The gluteus medius density was significantly higher in the superior gait group, with a cut-off value of 30.9 HU. However, no significant differences were found in the gluteus maximus density, CSA, or BMI-adjusted CSA. These findings partially support the hypothesis, emphasizing the importance of muscle evaluation in predicting postoperative gait performance.

  Aug. 2024, Cureus, 16(8) (8), e68176, English, International magazine

  Scientific journal


• 【骨折治療の現在地を知る!】感染・偽関節 偽関節患者に対する自家末梢血CD34陽性細胞移植による骨・血管再生医療について

  大江 啓介, 新倉 隆宏, 福井 友章, 隈部 洋平, 松本 知之, 黒田 良祐

  金原出版(株), Apr. 2024, 整形・災害外科, 67(5) (5), 681 - 687, Japanese


• Effects of high antibiotic concentrations applied to continuous local antibiotic perfusion on human bone tissue-derived cells.

  Yuya Yamamoto, Tomoaki Fukui, Kenichi Sawauchi, Ryo Yoshikawa, Kyohei Takase, Yohei Kumabe, Akihiro Maruo, Takahiro Niikura, Ryosuke Kuroda, Keisuke Oe

  AIMS: Continuous local antibiotic perfusion (CLAP) has recently attracted attention as a new drug delivery system for orthopaedic infections. CLAP is a direct continuous infusion of high-concentration gentamicin (1,200 μg/ml) into the bone marrow. As it is a new system, its influence on the bone marrow is unknown. This study aimed to examine the effects of high-concentration antibiotics on human bone tissue-derived cells. METHODS: Cells were isolated from the bone tissue grafts collected from six patients using the Reamer-Irrigator-Aspirator system, and exposed to different gentamicin concentrations. Live cells rate, apoptosis rate, alkaline phosphatase (ALP) activity, expression of osteoblast-related genes, mineralization potential, and restoration of cell viability and ALP activity were examined by in vitro studies. RESULTS: The live cells rate (the ratio of total number of cells in the well plate to the absorbance-measured number of live cells) was significantly decreased at ≥ 500 μg/ml of gentamicin on day 14; apoptosis rate was significantly increased at ≥ 750 μg/ml, and ALP activity was significantly decreased at ≥ 750 μg/ml. Real-time reverse transcription-polymerase chain reaction results showed no significant decrease in the ALP and activating transcription factor 4 transcript levels at ≥ 1,000 μg/ml on day 7. Mineralization potential was significantly decreased at all concentrations. Restoration of cell viability was significantly decreased at 750 and 1,000 μg/ml on day 21 and at 500 μg/ml on day 28, and ALP activity was significantly decreased at 500 μg/ml on day 28. CONCLUSION: Our findings suggest that the exposure concentration and duration of antibiotic administration during CLAP could affect cell functions. However, further in vivo studies are needed to determine the optimal dose in a clinical setting.

  Mar. 2024, Bone & joint research, 13(3) (3), 91 - 100, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Bactericidal effect of far ultraviolet-C irradiation at 222 nm against bacterial peritonitis.

  Kosuke Sugiyama, Kiyotaka Kurachi, Masaki Sano, Kyota Tatsuta, Tadahiro Kojima, Toshiya Akai, Katsunori Suzuki, Kakeru Torii, Mayu Sakata, Yoshifumi Morita, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Yohei Kumabe, Keisuke Oe, Tomoaki Fukui, Rena Kaigome, Masahiro Sasaki, Toru Koi, Hiroyuki Ohashi, Tetsuro Suzuki, Ryosuke Kuroda, Hiroya Takeuchi

  Far ultraviolet-C irradiation at 222 nm has potent bactericidal effects against severe infections such as peritonitis, with minimal cytotoxicity. Bacterial peritonitis due to bowel perforation is a serious condition with high mortality despite current treatments. This study investigated the safety and efficacy of intraperitoneal far ultraviolet-C irradiation at 222 nm. In vitro experiments optimized the fluid conditions for bacterial or protein concentrations prior to in vivo evaluation. In vivo efficacy was assessed in a rat peritonitis model induced by Escherichia coli, measuring intra-abdominal bacterial concentration, blood cytokine levels, and mortality rates. Safety was evaluated by analyzing cyclobutane pyrimidine dimers as markers of DNA damage in five abdominal organs: stomach, small intestine, colon, liver, and spleen. Statistical analyses employed parametric methods for normally distributed data and non-parametric methods for data without normality. Optimal in vitro conditions included 106 CFU/mL bacteria, 0.5 mW/cm2 irradiation, and 10-3 mg/mL protein. In the rat model, far ultraviolet-C irradiation at 222 nm significantly decreased intra-abdominal bacteria, reduced blood cytokines (interleukin-1β and interleukin-6), and elevated survival rates from 20% to 60%, compared to lavage alone. The formation of cyclobutane pyrimidine dimers was significantly lower with 222 nm irradiation than with 254 nm, suggesting reduced DNA damage. These findings indicate that far ultraviolet-C irradiation at 222 nm, when combined with lavage, represents a promising therapeutic strategy for bacterial peritonitis, providing effective bacterial reduction and a favorable safety profile. Further research is needed to verify these findings and investigate long-term safety and potential clinical applications.

  2024, PloS one, 19(11) (11), e0311552, English, International magazine

  Scientific journal


• Posterior Protrusion Measures (PPM) for Three-Dimensional (3D) CT Classification of Pertrochanteric Fractures.

  Mitsuaki Noda, Shunsuke Takahara, Atsuyuki Inui, Keisuke Oe, Shin Osawa, Takehiko Matsushita

  Introduction We introduced a novel numerical index known as posterior protrusion measures (PPM), derived from lateral plain radiograph images, which effectively serves to distinguish stable from unstable pertrochanteric fractures. The present study aims to scrutinize PPM values among two classified fracture patterns, stable and unstable, within the three-dimensional (3D) CT classification system, establishing a numeric threshold for PPM to differentiate between these groups; explore the potential relationship between the PPM index and unclassified categories; investigate how groups divided by the PPM threshold value can predict fracture stability based on 3D CT. Materials and methods In this study, three observers were tasked with measuring PPM on a single occasion. The chi-square test assessed the association between each demographic parameter on a categorical scale and stable/unstable groups. Continuous variables were also subject to examination. Receiver operating characteristic (ROC) analysis was employed to determine optimal cut-off points of PPM for predicting the presence of stable versus unstable groups. Additionally, the chi-square test examined the linear relation between separated groups based on the defined threshold PPM value and the stable/unstable groups. Results A total of 106 pertrochanteric fractures were identified using CT scan images and plain radiographs in the 3D CT classification system, revealing the stable group of 35 patients and the unstable group of 71 patients. The PPM values for stable/unstable fractures were, on average (± standard deviation), 0.34±0.25/0.50±0.29 for observer 1, 0.31±0.23/0.57±0.31 for observer 2, and 0.41±0.29/0.57±0.26 for observer 3, respectively (p<0.01). We established 0.3 as the cut-off value for PPM. The average PPM value among three observers represented each patient to assess fracture stability. The group with PPM <0.3 included 27 patients (16 stable and 11 unstable), and the group with PPM ≥0.3 group comprised 79 patients (19 stable and 60 unstable; p<0.005). Conclusion The present study revealed a significant difference in PPM values among stable and unstable 3D CT classification groups. Additionally, a threshold PPM value of 0.3 suggests a pivotal point for differentiating fracture stability. This innovative methodology makes a substantial contribution to clinical endeavors, potentially circumventing the necessity for 3D CT scanning.

  Dec. 2023, Cureus, 15(12) (12), e51363, English, International magazine

  Scientific journal


• 【偽関節治療のエキスパートを目指そう】偽関節に対する新しい治療法 CD34陽性細胞移植とBMP(bone morphogenetic protein)

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (株)メジカルビュー社, Nov. 2023, 関節外科, 42(11) (11), 1295 - 1302, Japanese


• Phase III clinical trial of autologous CD34 + cell transplantation to accelerate fracture nonunion repair.

  Ryosuke Kuroda, Takahiro Niikura, Tomoyuki Matsumoto, Tomoaki Fukui, Keisuke Oe, Yutaka Mifune, Hironobu Minami, Hiroshi Matsuoka, Kimikazu Yakushijin, Yoshiharu Miyata, Shinichiro Kawamoto, Tatsuo Kagimura, Yasuyuki Fujita, Atsuhiko Kawamoto

  BACKGROUND: We previously demonstrated that CD34 + cell transplantation in animals healed intractable fractures via osteogenesis and vasculogenesis; we also demonstrated the safety and efficacy of this cell therapy in an earlier phase I/II clinical trial conducted on seven patients with fracture nonunion. Herein, we present the results of a phase III clinical trial conducted to confirm the results of the previous phase studies using a larger cohort of patients. METHODS: CD34 + cells were mobilized via administration of granulocyte colony-stimulating factor, harvested using leukapheresis, and isolated using magnetic cell sorting. Autologous CD34 + cells were transplanted in 15 patients with tibia nonunion and 10 patients with femur nonunion, who were followed up for 52 weeks post transplantation. The main outcome was a reduction in time to heal the tibia in nonunion patients compared with that in historical control patients. We calculated the required number of patients as 15 based on the results of the phase I/II study. An independent data monitoring committee performed the radiographic assessments. Adverse events and medical device failures were recorded. RESULTS: All fractures healed during the study period. The time to radiological fracture healing was 2.8 times shorter in patients with CD34 + cell transplantation than in the historical control group (hazard ratio: 2.81 and 95% confidence interval 1.16-6.85); moreover, no safety concerns were observed. CONCLUSIONS: Our findings strongly suggest that autologous CD34 + cell transplantation is a novel treatment option for fracture nonunion. TRIAL REGISTRATION: UMIN-CTR, UMIN000022814. Registered on 22 June 2016.

  Oct. 2023, BMC medicine, 21(1) (1), 386 - 386, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 【FRIの診断と治療-骨折手術後感染の疑問に答える】巨大骨欠損の再建 Masquelet法

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (株)医学書院, Jun. 2023, 臨床整形外科, 58(6) (6), 787 - 797, Japanese


• Multicenter study on atypical femoral fractures in patients with bone metastases taking bone- modifying agents.

  Tomoaki Fukui, Keisuke Oe, Teruya Kawamoto, Masayuki Morishita, Ikuo Fujita, Shunsuke Takahara, Atsushi Sakurai, Takashi Iwakura, Keiji Yoshida, Kenjiro Ito, Etsuo Shoda, Takafumi Hiranaka, Masaya Tsunoda, Ryosuke Kuroda, Takahiro Niikura

  Bone-modifying agents (BMAs), with bone-resorptive inhibitory effects, such as zoledronic acid and denosumab, are widely used at higher doses for bone-related events caused by bone metastasis of malignant tumors. These drugs have been suggested to be associated with atypical femoral fractures (AFFs), and the relationship between BMAs and AFFs has attracted attention. To investigate the clinical features including bone union time of AFFs in patients administered BMA for bone metastasis, we conducted a retrospective multicenter study. Thirty AFFs from 19 patients were enrolled in this study. Thirteen patients had bilateral AFFs, and nineteen AFFs had prodromal symptoms. Eighteen AFFs underwent surgery after complete fracture, three failed to achieve bone union and required nonunion surgery, and 11 AFFs that achieved bone union had an average period until bone union of 16.2 months, which was much longer than that previously reported for ordinary AFFs. Seven patients discontinued the BMAs, but not due to AFFs. Stopping BMAs in patients with bone metastasis would make it difficult to secure their performance of activities of daily living, and AFF with BMA administration might require a longer time for union. Therefore, it would be important to prevent incomplete AFF from becoming complete AFF via prophylactic internal fixation.

  Jun. 2023, Journal of bone oncology, 40, 100478 - 100478, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effect of low-intensity pulsed ultrasound on osteogenic differentiation of human induced membrane-derived cells in Masquelet technique.

  Kyohei Takase, Tomoaki Fukui, Keisuke Oe, Kenichi Sawauchi, Ryo Yoshikawa, Yuya Yamamoto, Shinya Hayashi, Tomoyuki Matsumoto, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: The Masquelet technique is a relatively new method for large bone defect treatment. In this technique, grafted bone tissue is used, and after the cement is removed, the induced membrane (IM; that form around the cement spacers placed in the bone defect region) is thought to play an important role in promoting bone formation. On the other hand, low-intensity pulsed ultrasound (LIPUS) is known to promote fracture healing and angiogenesis through mechanical stimulation. This study aimed to investigate the in vitro effects of LIPUS on the osteogenic differentiation of human induced membrane-derived cells (IMCs). METHODS: Seven patients who had been treated using the Masquelet technique were enrolled. The IM was harvested during the second stage of the technique. IMCs were isolated, cultured in growth medium, and then divided into two groups: (1) control group, IMCs cultured in osteogenic medium without LIPUS, and (2) LIPUS group, IMCs cultured in osteogenic medium with LIPUS treatment. Adherent cells from the IM samples were harvested after the first passage and evaluated for cell surface protein expression using immunostaining. A cell proliferation assay was used to count the number of IMCs using a hemocytometer. Osteogenic differentiation capability was assessed using an alkaline phosphatase (ALP) activity assay, Alizarin Red S staining, and real-time reverse transcription-polymerase chain reaction. RESULTS: Cell surface antigen profiling revealed that the IMCs contained cells positive for the mesenchymal stem cell-related markers CD73, CD90, and CD105. No significant difference in cell numbers was found between the control and LIPUS groups. The ALP activity of IMCs in the LIPUS group was significantly higher than that in the control group on days 7 and 14. Alizarin red S staining intensity was significantly higher in the LIPUS group than in the control group on day 21. Runx2 and VEGF expression was significantly upregulated on days 7 and 14, respectively, compared with levels in the control group. CONCLUSION: We demonstrated the significant effect of LIPUS on the osteogenic differentiation of human IMCs. This study indicates that LIPUS can be used as an additional tool for the enhancement of the healing process of the Masquelet technique.

  Apr. 2023, Injury, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 偽関節治療の基礎研究と臨床応用

  新倉 隆宏, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Apr. 2023, 日本整形外科学会雑誌, 97(4) (4), 252 - 260, Japanese


• Infected Gustilo IIIB open knee joint fracture treated with an antimicrobial iodine-supported megaprosthesis: A case report.

  Shin Osawa, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Hiroyuki Tsuchiya, Takahiro Niikura

  Mar. 2023, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 28(2) (2), 495 - 498, English, Domestic magazine

  Scientific journal


• Nonunion of Hoffa Fracture Successfully Treated by Total Knee Arthroplasty: A Case Report.

  Toshiki Kitamura, Tomoaki Fukui, Tomoyuki Matsumoto, Keisuke Oe, Kenichi Sawauchi, Ryosuke Kuroda, Takahiro Niikura

  A Hoffa fracture is a rare type of femoral fracture that is difficult to treat. Nonoperative treatments usually result in failure; hence, in most cases, surgical treatments are essential. Nonunion following Hoffa fracture appears to be relatively uncommon, and there are limited reports in the literature about this type of nonunion. These reports suggest that open reduction and rigid internal fixation is the standard treatment for this type of nonunion. This study reports the case of a 61-year-old male patient who suffered from left lateral Hoffa fracture after falling from a truck bed. At the former hospital, open reduction and internal fixation were performed with plates and screws at 8 days post-injury. Postoperatively, displacement of the lateral proximal fragment was observed, and the patient reported left knee pain. Therefore, a revision open reduction and internal fixation was performed 4 months post-surgery. However, 6 months after the revision surgery, the patient reported instability and pain in the left knee, and subsequent radiography revealed nonunion of the fracture in the lateral condyle. The patient was referred to our hospital for further treatment. Treatment by re-revision open reduction and internal fixation was deemed challenging, and so rotating hinge knee (RHK) arthroplasty was performed as a salvage treatment. At 3 years post-surgery, no significant problems were observed, and the patient could walk without any assistance. The range of motion of the left knee was 0 to 100° without extension lag, and there was no lateral instability. Standard treatment for Hoffa fracture nonunion is commonly anatomical reduction and rigid internal fixation. However, total knee arthroplasty may be a better option for the treatment of Hoffa fracture nonunion in older patients.

  Mar. 2023, Cureus, 15(3) (3), e35780, English, International magazine

  Scientific journal


• Nonunion of Hoffa Fracture Successfully Treated by Total Knee Arthroplasty: A Case Report.

  Toshiki Kitamura, Tomoaki Fukui, Tomoyuki Matsumoto, Keisuke Oe, Kenichi Sawauchi, Ryosuke Kuroda, Takahiro Niikura

  A Hoffa fracture is a rare type of femoral fracture that is difficult to treat. Nonoperative treatments usually result in failure; hence, in most cases, surgical treatments are essential. Nonunion following Hoffa fracture appears to be relatively uncommon, and there are limited reports in the literature about this type of nonunion. These reports suggest that open reduction and rigid internal fixation is the standard treatment for this type of nonunion. This study reports the case of a 61-year-old male patient who suffered from left lateral Hoffa fracture after falling from a truck bed. At the former hospital, open reduction and internal fixation were performed with plates and screws at 8 days post-injury. Postoperatively, displacement of the lateral proximal fragment was observed, and the patient reported left knee pain. Therefore, a revision open reduction and internal fixation was performed 4 months post-surgery. However, 6 months after the revision surgery, the patient reported instability and pain in the left knee, and subsequent radiography revealed nonunion of the fracture in the lateral condyle. The patient was referred to our hospital for further treatment. Treatment by re-revision open reduction and internal fixation was deemed challenging, and so rotating hinge knee (RHK) arthroplasty was performed as a salvage treatment. At 3 years post-surgery, no significant problems were observed, and the patient could walk without any assistance. The range of motion of the left knee was 0 to 100° without extension lag, and there was no lateral instability. Standard treatment for Hoffa fracture nonunion is commonly anatomical reduction and rigid internal fixation. However, total knee arthroplasty may be a better option for the treatment of Hoffa fracture nonunion in older patients.

  Mar. 2023, Cureus, 15(3) (3), e35780, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Comparative Study of Different Entry Spots on Postoperative Gluteus Medius Muscle Cross-Sectional Area in Patients With Intertrochanteric Fractures Nailing.

  Mitsuaki Noda, Shunsuke Takahara, Atsuyuki Inui, Keisuke Oe, Shin Osawa, Takehiko Matsushita

  Introduction In a preliminary study of cephalo-medullary (CM) nailing in patients with femoral intertrochanteric fractures, the authors of this study found a 25% to 30% decrease in muscle strength, especially abduction force, during the postoperative follow-up period. This decline was partially attributed to the entry point for the nail insertion causing damage to the gluteus medius tendon at the junction of the greater trochanter after reaming. Therefore, we assumed that changing the position of nail insertion to a "bald spot (BS)" could mitigate postoperative functional impairment. Automated computed tomography (CT) imaging of skeletal muscle cross-sectional area (CSA) and adipose tissue ratio (ATR) can show pathological changes on the operated side compared with the non-operated side. In this study, the authors quantified the difference in postoperative CSA and ATR of the gluteus medius muscle after bald spot nailing versus nail insertion through the conventional tip of the greater trochanter. It was hypothesized that bald spot nailing could avoid significant injury to the gluteus medius muscle. Materials and methods Patients with femoral intertrochanteric fractures were grouped according to the site of cephalo-medullary nailing: greater trochanteric tip (TIP) in 27 patients (8 men and 19 women, mean age 84.9±5.1 years) and BS in 16 patients (3 men and 13 women, mean age 86.9±6.2 years). The CSA and ATR of the gluteus medius muscles were assessed in three slices (A, B, and C from proximal to distal). Each slice was manually traced and automatically calculated based on its contour. Adipose tissue (-100 to -50 in Hounsfield units) in the designated area was distinguished by a bimodal image histogram resulting from the distribution of CT numbers of adipose tissue and muscle. The body mass index (BMI) was used to correct the CSA in each patient. Results In the TIP group, the mean CSA values (mm2) from the non-operated/operated sides were as follows: slice A, 2180.2 ± 616.5/1976.3 ± 421.2; slice B, 2112.3 ± 535.7/1857.7 ± 386.7; and slice C: 1671.8 ± 460.0/1404.1 ± 404.3 (p<0.01 in slices A, B, and C). In the BS group, slice A was 2044.1 ± 473.0/2016.9 ± 388.4; slice B was 2073.2 ± 540.7/1848.3 ± 411.1; and slice C was 1659.1 ± 477.2/1468.5 ± 341.7 (p=0.34 in slice A, and p<0.05 in slices B and C, respectively). The mean CSA values (mm2) of the non-operated minus operated side between the TIP/BS groups were as follows: slice A, 241.3 ± 424.3/-11.8 ± 285.6; slice B, 290.3 ± 313.0/211.8 ± 333.2; and slice C, 276.4 ± 270.4/162.8 ± 319.3 (p < 0.05 in slice A, 0.45, 0.24 in slices B, C, respectively). The mean adjusted CSA per BMI values (mm2) of the non-operated minus the operated side between the TIP/BS groups were slice A, 10.6 ± 19.7/-0.4 ± 14.8; slice B, 13.3 ± 15.0/10.1 ± 16.3; and slice C, 13.1 ± 13.4/ 8.7 ± 15.3 (p < 0.05 in slice A and 0.54 and 0.36 in slices B and C, respectively). Conclusion Nail insertion at the bald spot resulted in a significantly smaller decrease in the CSA of the gluteus medius muscle compared with the conventional tip entry. In addition, an examination of BMI-adjusted CSA showed that CSA was maintained in some image slices. These results suggest that nailing from the BS of the greater trochanter can reduce damage to the gluteus medius muscle and highlight the importance of imaging beyond the usual assessment of skeletal changes.

  Mar. 2023, Cureus, 15(3) (3), e36103, English, International magazine

  Scientific journal


• A Demographic Survey of Pertrochanteric Fractures Based on the Revised Arbeitsgemeinschaft für Osteosynthesefragen/Orthopedic Trauma Association (AO/OTA) Classification Using 3D CT Scan Images.

  Mitsuaki Noda, Shunsuke Takahara, Ryota Nishida, Keisuke Oe, Atsuyuki Inui, Shin Osawa, Takehiko Matsushita

  Introduction A demographic survey of femoral pertrochanteric fractures provides several important information for the healthcare system of a country since this fracture is commonly seen in the elderly and has a poor postoperative functional prognosis that is a burden on society. The importance of accurately classifying pertrochanteric fractures as stable or unstable cannot be understated. However, the use of plain radiograph images alone is known to underestimate fracture severity with low inter- or intra-observer agreement. Computed tomography (CT) images offer information for a more accurate classification of pertrochanteric fractures. With this three-dimensional (3D) CT-based study using the revised Arbeitsgemeinschaft für Osteosynthesefragen/Orthopedic Trauma Association (AO/OTA) classification, the purpose of this study is to elucidate the epidemiological demography of patients with pertrochanteric fractures. Material and methods We retrospectively collected 808 patients from five hospitals, classified into two groups: stable (A1) or unstable (A2). Age, gender, fracture laterality, and surgery timing were identified as epidemiological variables. Patients with both preoperative plain radiographs and 3D CT scans were included in the study. The exclusion criteria were AO/OTA A3 type fractures, pathological fractures, previous ipsilateral surgery, 60 years old or younger, and conservatively treated patients. The primary outcome involved detailing the total number of fractures based on classification (A1 or A2) and variables. The secondary outcome involved a comparison between the A1 and A2 groups. Results The mean age of patients at the time of surgery was 85 years (range: 61-103 years). There were 637 female and 171 male patients. There were 463 left-sided fractures and 345 right-sided fractures. Of the 808 patients, 371 (45.9%) were classified to have A1 fractures, and 437 (54.1%) had A2 fractures. The age at surgery, gender, fracture laterality, and surgery timing between the A1 and A2 groups were compared. The mean and standard deviation of the age at surgery for patients in the A1 and A2 groups were 84.9±7.7 and 86.9±6.8, respectively. The number of patients for each age distribution of 61-69, 70-74, 75-79, 80-84, 85-89, 90-94, and 95 or older for the A1 and A2 groups was 18 and 7, 18 and 12, 43 and 44, 76 and 82, 107 and 132, 79 and 110, and 30 and 50, respectively, showing that the difference in categorial distribution was statistically significant (p=0.002). Overall, 278 females and 93 males were classified to have A1 fractures compared with 359 females and 78 males with A2 fractures (p=0.01). There were 166 right-sided and 205 left-sided stable A1 fractures and 179 right-sided and 258 left-sided A2 fractures (not significant (NS)). Among the total number of A1 and A2 surgeries by month, the most were in December with 77 surgeries (37 and 40, respectively), and the least was in June with 37 (18 and 19, respectively). The seasonal classification for A1 and A2 surgeries is as follows: spring with 172 (74 and 98, respectively), summer with 150 (70 and 80, respectively), autumn with 193 (90 and 103, respectively), and winter with 208 (97 and 111, respectively) (NS). Conclusion In this demographic study of 808 patients with pertrochanteric fractures classified by 3D CT images, 371 had A1 fractures and 437 had A2 fractures. A2 fractures were significantly more in females with an age peak of 85-89 years.

  Jan. 2023, Cureus, 15(1) (1), e33572, English, International magazine

  Scientific journal


• Osteomyelitis of the Pubis Treated by Masquelet Technique in a Football Player: A Case Report.

  Hitomi Kitamura, Tomoaki Fukui, Keisuke Oe, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: Osteomyelitis pubis is a rare disease that presents with fever, pubic or hip pain, pain during hip movement, and claudication to avoid pain. It most frequently affects young athletes involved in sports that require twisting and cutting, but its exact cause is unknown and no definite treatment has been established. We report a case of pubic osteomyelitis in a young football player who was treated using the Masquelet technique and antibiotics with a good clinical course. CASE REPORTS: A 22-year-old male football player in a national-level university club team visited a nearby clinic complaining of high fever and mild pain in his bilateral hip joints. As a result of examination, we diagnosed osteomyelitis pubis and reconstructed the pubic symphysis by the Masquelet technique. In this case, the joint-like structure of the pubic symphysis was successfully reconstructed, and the patient was able to continue playing the sport. Three years and 3 months after surgery, he had no limitation of bilateral hip joint range of motion and did not display any symptoms while playing football. CONCLUSION: Masquelet technique could be a novel surgical method for managing osteomyelitis pubis, even in athletes.

  Dec. 2022, Journal of orthopaedic case reports, 12(12) (12), 39 - 42, English, International magazine

  Scientific journal


• Posterior Protrusion Measures (PPM) as an Innovative Index in Classifying Plain Lateral Radiograph Images of Pertrochanteric Fracture Using the Revised AO Foundation/Orthopaedic Trauma Association (AO/OTA) Classification.

  Mitsuaki Noda, Shunsuke Takahara, Atsuyuki Inui, Keisuke Oe, Shin Osawa, Takehiko Matsushita

  Introduction The absence of a precise fracture classification system that classifies pertrochanteric fractures into either stable or unstable contributes to a burden on healthcare and has several major implications. We propose an innovative graphical index, which we refer to as posterior protrusion measures (PPM), using plain lateral view radiograph images for the revised AO Foundation (Arbeitsgemeinschaft für Osteosynthesesfragen)/Orthopedic Trauma Association (AO/OTA) classification system. This study aims to: (i) introduce the use of PPM for classifying fractures into stable or unstable under the revised AO/OTA classification system and set the threshold numeric value, (ii) elucidate the reproducibility of inter and intra-observer agreement, and investigate the consistency of fracture classification using PPM versus computed tomography (CT) scan images. Materials and methods Out of 146 patients identified from the database, a total of 126 patients were enrolled in the study. Pertrochanteric fractures were classified as either stable or unstable. Three surgeons were assigned for PPM determination. Regarding the demographical data, the chi-square test was used to assess the significance of each parameter on a categorical scale between the two groups. The independent sample t-test or the Mann-Whitney U test was used to compare the two independent groups. Interclass correlation coefficient (ICC) values for continuous variables and kappa values (κ) for categorical variables were calculated to assess inter-observer and intra-observer agreement. Receiver-operating characteristic (ROC) analysis was used to determine optimal cut-off points of PPM to predict consistency between separate fracture classification groups, one using PPM values with a threshold derived from plain radiograph images, and the other using CT scan images. Results Among a total of 126 pertrochanteric fractures, the A1 (stable) group consisted of 39 patients (10 males, 29 females), whereas the A2 (unstable) group consisted of 87 patients (14 males, 73 females) (not significant, NS). Intraclass correlation coefficient (ICC) values of PPM for the inter-observer agreement were 0.796 (0.723-0.852), 0.664 (0.554-0.751), and 0.702 (0.601-0.781) at first examination and 0.729 (0.635-0.801) at the second. The intra-observer agreement was 0.869 (0.819-0.906) and 0.603 (0.480-0.703). We examined for consistency of fracture classification group of PPM values with a threshold of 0.4 (A1<0.4, A2=0.4 or more) and CT-based group. For the first examination, there was mostly "moderate" agreement in fracture classification (stable or unstable) between plain radiograph and CT scan images, κ (95%CI): 0.427 (0.266-0.588), 0.493 (0.335-0.651), and 0.359 (0.176-0.544), and for the second, 0.418 (0.251-0.585), and 0.451 (0.284-0.620), respectively. Conclusion We propose a supplementary tool, namely PPM that allows for possible alternative classification of pertrochanteric fractures into A1 (stable) and A2 (unstable) using plain radiograph images under the revised AO/OTA classification system. In this study, a PPM threshold value of 0.4 demonstrated a moderate inter- and intra-observer agreement. It is noteworthy to mention that there was a satisfactory consistency of fracture classification using PPM derived from plain radiograph images when compared to classification using CT scan images. In addition, the PPM method provides a numerical score.

  Dec. 2022, Cureus, 14(12) (12), e32898, English, International magazine

  Scientific journal


• Osteomyelitis of the Pubis Treated by Masquelet Technique in a Football Player: A Case Report.

  Hitomi Kitamura, Tomoaki Fukui, Keisuke Oe, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: Osteomyelitis pubis is a rare disease that presents with fever, pubic or hip pain, pain during hip movement, and claudication to avoid pain. It most frequently affects young athletes involved in sports that require twisting and cutting, but its exact cause is unknown and no definite treatment has been established. We report a case of pubic osteomyelitis in a young football player who was treated using the Masquelet technique and antibiotics with a good clinical course. CASE REPORTS: A 22-year-old male football player in a national-level university club team visited a nearby clinic complaining of high fever and mild pain in his bilateral hip joints. As a result of examination, we diagnosed osteomyelitis pubis and reconstructed the pubic symphysis by the Masquelet technique. In this case, the joint-like structure of the pubic symphysis was successfully reconstructed, and the patient was able to continue playing the sport. Three years and 3 months after surgery, he had no limitation of bilateral hip joint range of motion and did not display any symptoms while playing football. CONCLUSION: Masquelet technique could be a novel surgical method for managing osteomyelitis pubis, even in athletes.

  Dec. 2022, Journal of orthopaedic case reports, 12(12) (12), 39 - 42, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Influence of Metal Implants on Quantitative Evaluation of Bone Single-Photon Emission Computed Tomography/Computed Tomography.

  Keisuke Oe, Feibi Zeng, Takahiro Niikura, Tomoaki Fukui, Kenichi Sawauchi, Tomoyuki Matsumoto, Munenobu Nogami, Takamichi Murakami, Ryosuke Kuroda

  When visualizing biological activity at nonunion sites by the radioisotopes, gamma rays are more attenuated if metal implants are placed in the bone. However, the effects of various implant types and their placement on gamma ray attenuation in quantitative evaluation remain unknown. To elucidate these effects, we created a phantom that simulated the nonunion of the femur in this study. The count of gamma rays was measured by single-photon emission computed tomography/computed tomography (SPECT/CT) while considering CT-based attenuation correction (CTAC), metal implant placement, type (intramedullary nail or plate), and position. The count differed significantly with and without CTAC and with and without implants (both types) under CTAC. Significantly different counts were observed between the intramedullary nail and plate placed contralaterally to the lesion (i.e., non-lesion side). No significant difference was observed between the intramedullary nail and plate on the lesion side or between plates on the non-lesion and lesion sides. The measured standardized uptake value (SUV) was closer to the true SUV with CTAC than without. Moreover, the count was higher with implants than without. However, even with implants, it was lower than the actual count, indicating the absence of overcorrection. Implant type and position do not seem to influence the count.

  Nov. 2022, Journal of clinical medicine, 11(22) (22), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Human Non-Hypertrophic Nonunion Tissue Contains Osteoblast Lineage Cells and E-BMP-2 Activates Osteogenic and Chondrogenic Differentiation.

  Ryo Yoshikawa, Tomoaki Fukui, Keisuke Oe, Yohei Kumabe, Takahiro Oda, Kenichi Sawauchi, Kyohei Takase, Yuya Yamamoto, Yoshitada Sakai, Ryosuke Kuroda, Takahiro Niikura

  In this study, we examined the proliferation capability and osteogenic and chondrogenic differentiation potential of non-hypertrophic nonunion cells (NHNCs), and the effect of Escherichia coli-derived BMP-2 (E-BMP-2) on them. We enrolled five patients with non-hypertrophic nonunion. NHNCs isolated from nonunion tissue sampled during surgery were cultured, passaged, counted every 14 days, and analyzed. NHNCs were homogenous fibroblastic adherent cells and long-lived through at least 10 passages, with a slight decline. The cells were consistently positive for mesenchymal stem cell-related markers CD73 and CD105, and negative for the hematopoietic markers CD14 and CD45. NHNCs could differentiate into osteoblast lineage cells; however, they did not have strong calcification or sufficient chondrogenic differentiation capability. E-BMP-2 did not affect the proliferative capability of the cells but improved their osteogenic differentiation capability by increasing alkaline phosphatase activity and upregulating the gene expression of osterix, bone sialoprotein, and osteocalcin. E-BMP-2 enhanced their chondrogenic differentiation capability by upregulating the gene expression of aggrecan and collagen type II. We showed, for the first time, that NHNCs have the capacity to differentiate into osteoblast-lineage cells, although the chondrogenic differentiation potential was poor. Local application of E-BMP-2 with preservation of nonunion tissue is a potential treatment option for non-hypertrophic nonunion.

  Nov. 2022, Current issues in molecular biology, 44(11) (11), 5562 - 5578, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Safety of 222 nm UVC Irradiation to the Surgical Site in a Rabbit Model.

  Tomoaki Fukui, Takahiro Niikura, Takahiro Oda, Yohei Kumabe, Aiko Nishiaki, Rena Kaigome, Hiroyuki Ohashi, Masahiro Sasaki, Tatsushi Igarashi, Keisuke Oe, Michael R Hamblin, Ryosuke Kuroda

  For the prevention of surgical site infection (SSI), continuous disinfection could be helpful. Short wavelength ultraviolet radiation C (UVC) is highly bactericidal but shows cytotoxicity. Radiation of UVC with a wavelength of 222 nm to the skin is considered to be safe because it only reaches the stratum corneum. However, the safety of 222 nm irradiation to the surgical field not covered with skin is unknown. The purpose of this study was to examine the safety of 222 nm UVC irradiation on a surgical field in a rabbit model. Five types of tissue were surgically exposed and irradiated with 222 or 254 nm UVC. Immunohistological assessment against cyclobutane pyrimidine dimer (CPD), an index of DNA damage by UVC, was performed. The CPD-positive cell rate was significantly higher in the 254 nm group than in the other groups in all tissues. A 222 nm group showed significantly more CPD than control in fat tissue, but no significant difference in all other tissues. In fat tissue collected 24 h after irradiation, the 254 nm group showed higher CPD than the other groups, while the 222 nm group had reduced to the control level. These data suggest that 222 nm UVC irradiation could be a new method to safely prevent SSI.

  Nov. 2022, Photochemistry and photobiology, 98(6) (6), 1365 - 1371, English, International magazine

  Scientific journal


• Management of Infected Non-union Following Femoral Shaft Fracture in a Patient with Klippel-Trenaunay Syndrome: A Case Report.

  Tetsuro Kurashina, Tomoaki Fukui, Keisuke Oe, Kenichi Sawauchi, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: The etiology of Klippel-Trenaunay syndrome (KTS) has a significant impact on the management of patient requiring surgical interventions. We report the strategies employed to address an infected non-union in a patient with KTS. CASE REPORT: The patient was transported to an initial treating hospital with femoral shaft fracture after experiencing a fall. The patient was diagnosed with KTS due to vascular malformations identified after severe intraoperative hemorrhaging. An open reduction and internal fixation was performed to stabilize the bone. Nine months after surgery, the patient was transferred to our hospital due to lack of healing with infected non-union. We prioritized treating the infection and plate displacement, and subsequently performed intramedullary nailing. Infection and intraoperative hemorrhaging were successfully controlled and bone union was confirmed 6 months after surgery. CONCLUSION: The key factors to minimize procedural complications are sufficient preoperative evaluation and planning, surgical skill, and perioperative resource management.

  Jul. 2022, Journal of orthopaedic case reports, 12(7) (7), 38 - 41, English, International magazine

  Scientific journal


• Management of Infected Non-union Following Femoral Shaft Fracture in a Patient with Klippel-Trenaunay Syndrome: A Case Report.

  Tetsuro Kurashina, Tomoaki Fukui, Keisuke Oe, Kenichi Sawauchi, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: The etiology of Klippel-Trenaunay syndrome (KTS) has a significant impact on the management of patient requiring surgical interventions. We report the strategies employed to address an infected non-union in a patient with KTS. CASE REPORT: The patient was transported to an initial treating hospital with femoral shaft fracture after experiencing a fall. The patient was diagnosed with KTS due to vascular malformations identified after severe intraoperative hemorrhaging. An open reduction and internal fixation was performed to stabilize the bone. Nine months after surgery, the patient was transferred to our hospital due to lack of healing with infected non-union. We prioritized treating the infection and plate displacement, and subsequently performed intramedullary nailing. Infection and intraoperative hemorrhaging were successfully controlled and bone union was confirmed 6 months after surgery. CONCLUSION: The key factors to minimize procedural complications are sufficient preoperative evaluation and planning, surgical skill, and perioperative resource management.

  Jul. 2022, Journal of orthopaedic case reports, 12(7) (7), 38 - 41, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy.

  Yu Hirata, Kazuhiro Nomura, Daisuke Kato, Yoshihisa Tachibana, Takahiro Niikura, Kana Uchiyama, Tetsuya Hosooka, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Yuji Hara, Takahiro Adachi, Koji Shibasaki, Hiroaki Wake, Wataru Ogawa

  Although immobility is a common cause of muscle atrophy, the mechanism underlying this causality is unclear. We here show that Krüppel-like factor 15 (KLF15) and IL-6 are upregulated in skeletal muscle of limb-immobilized mice and that mice with KLF15 deficiency in skeletal muscle or with systemic IL-6 deficiency are protected from immobility-induced muscle atrophy. A newly developed Ca2+ bioimaging revealed that the cytosolic Ca2+ concentration ([Ca2+]i) of skeletal muscle is reduced to below the basal level by immobilization, which is associated with the downregulation of Piezo1. Acute disruption of Piezo1 in skeletal muscle induced Klf15 and Il6 expression as well as muscle atrophy, which was prevented by antibodies against IL-6. A role for the Piezo1/KLF15/IL-6 axis in immobility-induced muscle atrophy was validated in human samples. Our results thus uncover a paradigm for Ca2+ signaling in that a decrease in [Ca2+]i from the basal level triggers a defined biological event.

  May 2022, The Journal of clinical investigation, 132(10) (10), 1 - 13, English, International magazine

  Scientific journal


• Safety of 222 nm UVC irradiation to the surgical site in a rabbit model.

  Tomoaki Fukui, Takahiro Niikura, Takahiro Oda, Yohei Kumabe, Aiko Nishiaki, Rena Kaigome, Hiroyuki Ohashi, Masahiro Sasaki, Tatsushi Igarashi, Keisuke Oe, Michael R Hamblin, Ryosuke Kuroda

  For the prevention of surgical site infection (SSI), continuous disinfection could be helpful. Short wavelength ultraviolet radiation C (UVC) is highly bactericidal but shows cytotoxicity. Radiation of UVC with a wavelength of 222 nm to the skin is considered to be safe because it only reaches the stratum corneum. However, the safety of 222 nm irradiation to the surgical field not covered with skin is unknown. The purpose of this study was to examine the safety of 222 nm UVC irradiation on a surgical field in a rabbit model. Five types of tissue were surgically exposed and irradiated with 222 or 254 nm UVC. Immunohistological assessment against cyclobutane pyrimidine dimer (CPD), an index of DNA damage by UVC, was performed. The CPD-positive cell rate was significantly higher in the 254 nm group than in the other groups in all tissues. A 222 nm group showed significantly more CPD than control in fat tissue, but no significant difference in all other tissues. In fat tissue collected 24 h after irradiation, the 254 nm group showed higher CPD than the other groups, while the 222 nm group had reduced to the control level. These data suggest that 222 nm UVC irradiation could be a new method to safely prevent SSI.

  Mar. 2022, Photochemistry and photobiology, 98(6) (6), 1365 - 1371, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy

  Yu Hirata, Kazuhiro Nomura, Daisuke Kato, Yoshihisa Tachibana, Takahiro Niikura, Kana Uchiyama, Tetsuya Hosooka, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Yuji Hara, Takahiro Adachi, Koji Shibasaki, Hiroaki Wake, Wataru Ogawa

  American Society for Clinical Investigation, Mar. 2022, Journal of Clinical Investigation

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Endochondral Bone Tissue Engineering Using Human Induced Pluripotent Stem Cells.

  Michio Arakura, Sang Yang Lee, Tomoaki Fukui, Keisuke Oe, Shunsuke Takahara, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  The use of induced pluripotent stem cells (iPSCs) shows potential in bone regenerative strategies. In this study, we investigated whether implantation of chondrogenically differentiated iPSC-derived mesenchymal stem cells (iMSCs) can lead to successful bone regeneration in nude mice with bone defects. Two human iPSC clones (201B7 and 454E2) were used. After generating iMSCs, chondrogenic differentiation was achieved by three-dimensional pellet culture. Thereafter, a 2-mm defect was created in the radius of nude mice, and chondrogenically differentiated iMSC pellets were transplanted in the defect. Microcomputed tomography imaging was performed 8 weeks posttransplantation to assess bone regeneration. All (100%) radii in the 201B7 cell-derived pellet transplantation group and 7 of 10 (70%) radii in the 454E2 cell-derived pellet transplantation group showed bone union. In contrast, 2 of 11 radii (18%) in the control group showed bone union. Thus, the experimental groups showed significantly higher bone union rates than the control group (p < 0.05). Histological analysis 2 weeks postimplantation in the experimental groups revealed hypertrophic chondrocytes within grafted iMSC pellets and the formation of woven bone around them. This hypertrophic chondrocyte transitioning to newly formed bone suggests that the cartilaginous template can trigger endochondral bone ossification (ECO). Four weeks postimplantation, the cartilage template was reduced in size; newly formed woven bone was predominant in the defect site. New vessels were surrounded by a matrix of woven bone, and hypertrophic chondrocytes transitioning to newly formed bone indicated the progression of ECO. Eight weeks postimplantation, the pellets were completely resorbed and replaced by bone; complete bone union was observed. Dense mature bone developed with evidence of lamellar-like bone formation. Collectively, our results suggest that using iMSC-based cartilage grafts recapitulating the morphogenetic process of ECO in the context of embryonic skeletogenesis is a promising strategy for repairing large bone defects. Impact statement We investigated whether implantation of chondrogenically differentiated iPSC-derived mesenchymal stem cells (iMSCs) could lead to the successful regeneration of bone defects in vivo. We implanted two different clones of human induced pluripotent stem cells into a radial bone defect model. Eleven of 11 (100%) and 7 of 10 (70%) radii in the 201B7 and 454E2 cell-derived pellet transplantation groups, respectively, showed bone union, which were significantly higher than those in the control group [only 2 of 11 radii (18%)]. Overall, our results support the use of iMSC-based cartilage grafts recapitulating the morphogenetic process of endochondral bone ossification for repairing large bone defects.

  Feb. 2022, Tissue engineering. Part A, 28(3-4) (3-4), 184 - 195, English, International magazine

  Scientific journal


• Low-Intensity Pulsed Ultrasound Promotes Osteogenic Differentiation of Reamer-Irrigator-Aspirator Graft-Derived Cells in Vitro.

  Kenichi Sawauchi, Tomoaki Fukui, Keisuke Oe, Yohei Kumabe, Takahiro Oda, Ryo Yoshikawa, Kyohei Takase, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  Recently, reamer-irrigator-aspirator (RIA) systems have been increasingly used to harvest autologous bone grafts. RIA graft materials contain bone marrow, which provides a viable source to derive large numbers of mesenchymal stem cells. Low-intensity pulsed ultrasound (LIPUS) significantly accelerates the differentiation of stem cells derived from bone marrow. This in vitro study investigated the effect of LIPUS on the osteogenic activity and differentiation of RIA graft-derived cells. A small amount of RIA graft was obtained from seven patients. After the cells derived from RIA grafts were cultured, they were divided into two groups: the LIPUS and control groups. LIPUS was applied once daily for 20 min (1.5 MHz, pulse duration: 200 µs, pulse repetition rate: 1 kHz, spatial average-temporal average intensity: 30 mW/cm2). Alkaline phosphatase activity (113.4% and 130.1% on days 7 and 14), expression of osteoblast-related genes (ALP, Runx2) and mineralization (135.2% on day 21) of the RIA graft-derived cells were significantly higher in the LIPUS group than in the control group. However, LIPUS did not affect the cell proliferation of RIA graft-derived cells. This study indicates that LIPUS may enhance the healing of non-union and critical bone defects treated by autologous bone grafting using the RIA system.

  Feb. 2022, Ultrasound in medicine & biology, 48(2) (2), 313 - 322, English, International magazine

  Scientific journal


• Continuous Local Antibiotic Perfusion (CLAP) for Post-operative Infection of Open Tibial Fractures: A Case Report.

  Ryowa Mineo, Keisuke Oe, Takahiro Niikura, Hirotsugu Muratsu, Ryosuke Kuroda, Akihiro Maruo

  INTRODUCTION: We encountered a case of post-operative infection of an open tibial fracture that was controlled by continuous local antibiotic perfusion (CLAP), a novel method of fracture-related infection (FRI) that we have developed. CLAP is a procedure in which a bone marrow needle and a double lumen tube are placed in the infected area, and an appropriate concentration of antimicrobial agent is continuously administered and perfused. CASE REPORT: The patient was a 78-year-old woman. She was hit by a motor vehicle and fell to the farmyard floor. She suffered multiple traumas, including a lower leg open fracture, multiple rib fractures, clavicle fracture, pelvic fracture, mandibular fracture, and liver injury. Her tibial fracture was a Gustilo-Anderson type IIIA open fracture. After debridement and external fixation of the tibial open fracture on the same day, open reduction and internal fixation with an intramedullary nail was performed 3 days after the injury. Twelve days after the injury, local heat and redness were observed at the nail insertion wound and the posteromedial calf, and a purulent clot was discharged from the open wound. We performed curettage of the lesion and retained the implant. CLAP was then constructed to perfuse local antibiotics along the nail and large hematoma area. Locally, the inflammation improved and the inflammatory response became negative 3 weeks after the initiation of CLAP. Six months after surgery, bony union was achieved. At present, 3.5 years after the internal operation, there is no sign of infection, and the patient has returned to her pre-injury life with no abnormalities in motor function. CONCLUSION: CLAP may be a novel treatment method that can be expected to achieve bone healing while preserving the implant in FRI cases after open tibial fracture.

  Feb. 2022, Journal of orthopaedic case reports, 12(2) (2), 18 - 22, English, International magazine

  Scientific journal


• Continuous Local Antibiotic Perfusion (CLAP) for Post-operative Infection of Open Tibial Fractures: A Case Report.

  Ryowa Mineo, Keisuke Oe, Takahiro Niikura, Hirotsugu Muratsu, Ryosuke Kuroda, Akihiro Maruo

  INTRODUCTION: We encountered a case of post-operative infection of an open tibial fracture that was controlled by continuous local antibiotic perfusion (CLAP), a novel method of fracture-related infection (FRI) that we have developed. CLAP is a procedure in which a bone marrow needle and a double lumen tube are placed in the infected area, and an appropriate concentration of antimicrobial agent is continuously administered and perfused. CASE REPORT: The patient was a 78-year-old woman. She was hit by a motor vehicle and fell to the farmyard floor. She suffered multiple traumas, including a lower leg open fracture, multiple rib fractures, clavicle fracture, pelvic fracture, mandibular fracture, and liver injury. Her tibial fracture was a Gustilo-Anderson type IIIA open fracture. After debridement and external fixation of the tibial open fracture on the same day, open reduction and internal fixation with an intramedullary nail was performed 3 days after the injury. Twelve days after the injury, local heat and redness were observed at the nail insertion wound and the posteromedial calf, and a purulent clot was discharged from the open wound. We performed curettage of the lesion and retained the implant. CLAP was then constructed to perfuse local antibiotics along the nail and large hematoma area. Locally, the inflammation improved and the inflammatory response became negative 3 weeks after the initiation of CLAP. Six months after surgery, bony union was achieved. At present, 3.5 years after the internal operation, there is no sign of infection, and the patient has returned to her pre-injury life with no abnormalities in motor function. CONCLUSION: CLAP may be a novel treatment method that can be expected to achieve bone healing while preserving the implant in FRI cases after open tibial fracture.

  Feb. 2022, Journal of orthopaedic case reports, 12(2) (2), 18 - 22, English, International magazine


• Immunohistochemical analysis revealed the expression of bone morphogenetic proteins-4, 6, 7, and 9 in human induced membrane samples treated with the Masquelet technique.

  Takahiro Niikura, Takahiro Oda, Naoe Jimbo, Masato Komatsu, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Tomoo Itoh, Ryosuke Kuroda

  BACKGROUND: Induced membrane (IM) is the key component of Masquelet reconstruction surgery for the treatment of bone defects. IM is formed around the cement spacer and is known to secrete growth factors and osteoinductive factors. However, there is limited evidence available concerning the presence of osteoinductive factors in IM. This study aimed to investigate the existence of bone morphogenetic proteins (BMPs) in IM harvested from patients during the treatment of bone defects using the Masquelet technique. METHODS: This study involved six patients whose bone defects had been treated using the Masquelet technique. The affected sites were the femur (n = 3) and the tibia (n = 3). During the second-stage surgery, 1 cm2 pieces of IM were harvested. Histological sections of IM were immunostained with anti-BMP-4, 6, 7, and 9 antibodies. Human bone tissue served as the positive control. RESULTS: The presence of BMP-4, 6, 7, and 9 was observed in all IM samples. Further, immunolocalization of BMP-4, 6, 7, and 9 was observed in blood vessels and fibroblasts in all IM samples. Immunolocalization of BMP-4, 6, 7, and 9 was also observed in bone tissue within the IM in one sample, in which osteogenesis inside the IM was observed. CONCLUSIONS: This study showed that osteoinductive factors BMP-4, 6, 7, and 9 were present in the IM harvested from patients, providing evidence indicating that the Masquelet technique effectively contributes to healing large bone defects. Therefore, it may be possible for surgeons to omit the addition of BMPs to bone grafts, given the endogenous secretion of BMPs from the IM.

  Jan. 2022, Journal of orthopaedic surgery and research, 17(1) (1), 29 - 29, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Combined treatment using cross-leg free flap and the Masquelet technique: a report of two cases.

  Takeo Osaki, Yasuko Hasegawa, Ryosuke Tamura, Tomoaki Fukui, Keisuke Oe, Takahiro Niikura, Tadashi Nomura, Kazunobu Hashikawa, Hiroto Terashi

  We introduce a treatment that combines the cross-leg free flap with the Masquelet technique and describe two cases using this method for bone and soft tissue reconstruction. Both patients were successfully treated and ambulatory. This novel method can be safely performed using the delay technique, indocyanine-green angiography and near-infrared spectroscopy.

  2022, Case reports in plastic surgery & hand surgery, 9(1) (1), 99 - 104, English, International magazine

  Scientific journal


• A Case of Nonunion with Ballooning Deformity after Periprosthetic Humeral Fracture.

  Yutaka Matsumiya, Keisuke Oe, Tomoaki Fukui, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: We report a very rare case of nonunion with ballooning deformity of the humeral bone after a periprosthetic humeral fracture nonunion. CASE REPORT: A 79-year-old woman underwent hemiarthroplasty 19 years ago for her proximal humerus fracture. She injured her right humeral diaphysis (stem distal end fracture) 6 years ago. She underwent revision hemiarthroplasty with long stem, but bony union was not obtained, and her right upper limb function was subsequently abolished due to extreme instability and pain in her right upper arm. She was then referred to our hospital for further treatment. X-ray showed nonunion in the humeral diaphysis and a severe ballooning deformity in the distal humeral bone fragment. Due to the advanced age and low activity of the patient, we chose total humerus replacement surgery instead of osteosynthesis. After the surgery, her upper arm pain and instability immediately improved. Three years after the last surgery, there have been no implant failures, and the upper arm is stable and painless. CONCLUSION: Although there are some reports of total humerus replacement as surgical treatment for humeral tumor and severe periprosthetic fracture, we found no reports of such ballooning deformity around the nonunion site. Total humerus replacement can be one of the treatment options in cases where nonunion surgery is extremely difficult, depending on the patient's age and activities of daily living.

  Jan. 2022, Journal of orthopaedic case reports, 12(1) (1), 89 - 91, English, International magazine

  Scientific journal


• Combined treatment using cross-leg free flap and the Masquelet technique: a report of two cases.

  Takeo Osaki, Yasuko Hasegawa, Ryosuke Tamura, Tomoaki Fukui, Keisuke Oe, Takahiro Niikura, Tadashi Nomura, Kazunobu Hashikawa, Hiroto Terashi

  We introduce a treatment that combines the cross-leg free flap with the Masquelet technique and describe two cases using this method for bone and soft tissue reconstruction. Both patients were successfully treated and ambulatory. This novel method can be safely performed using the delay technique, indocyanine-green angiography and near-infrared spectroscopy.

  2022, Case reports in plastic surgery & hand surgery, 9(1) (1), 99 - 104, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Continuous local antibiotic perfusion: A treatment strategy that allows implant retention in fracture-related infections.

  Akihiro Maruo, Takahiro Oda, Ryowa Mineo, Hidetoshi Miya, Hirotsugu Muratsu, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Takahiro Niikura

  PURPOSE: Fracture-related infections are difficult to treat because of the formation of biofilms around implants. Systemic antibiotics are notoriously ineffective against biofilms due to their insufficient penetration of tissues with poor vascularity. The goal of treating fracture-related infections is to achieve bone union while retaining the implant. Our proposal of continuous local antibiotic perfusion is a sustained local delivery system of sufficient antibiotics to bone and soft tissue infection sites, including to bone marrow via needles as intra-medullary antibiotics perfusion and to soft-tissue via double-lumen subcutaneous tubes as intra-soft tissue perfusion. METHODS: In this study, we examined the outcomes of 40 patients treated for fracture-related infections using continuous local antibiotic perfusion between 2015 and 2021 at Steel Memorial Hirohata Hospital, Himeji, Japan. RESULT: The antibiotic used for continuous local antibiotic perfusion was gentamicin in all cases. Implant removal was required in five patients. Two patients required toe amputation and knee arthrodesis, while the remaining 38 patients achieved fracture union. Only one case of transient acute renal injury as a systemic side effect was observed, but it soon resolved. The blood concentration of gentamicin could be adjusted to less than the trough level. CONCLUSIONS: Continuous local antibiotic perfusion is a novel local drug delivery system that has the potential of delivering sufficient concentrations of antibiotics with few systemic side effects; it is a useful option for the treatment of fracture-related infections.

  2022, Journal of orthopaedic surgery (Hong Kong), 30(2) (2), 10225536221111902 - 10225536221111902, English, International magazine

  Scientific journal


• Simulation Of Bone Fracture Healing Process Using Ultrasound And BMD Data.

  Takumi Ueyama, Yohei Kumabe, Keisuke Oe, Tomoaki Fukui, Takahiro Niikura, Ryosuke Kuroda, Masakazu Morimoto, Naomi Yagi, Yutaka Hata

  2022, ICMLC, 259 - 264

  International conference proceedings


• A Case of Nonunion with Ballooning Deformity after Periprosthetic Humeral Fracture.

  Yutaka Matsumiya, Keisuke Oe, Tomoaki Fukui, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Introduction: We report a very rare case of nonunion with ballooning deformity of the humeral bone after a periprosthetic humeral fracture nonunion. Case Report: A 79-year-old woman underwent hemiarthroplasty 19 years ago for her proximal humerus fracture. She injured her right humeral diaphysis (stem distal end fracture) 6 years ago. She underwent revision hemiarthroplasty with long stem, but bony union was not obtained, and her right upper limb function was subsequently abolished due to extreme instability and pain in her right upper arm. She was then referred to our hospital for further treatment. X-ray showed nonunion in the humeral diaphysis and a severe ballooning deformity in the distal humeral bone fragment. Due to the advanced age and low activity of the patient, we chose total humerus replacement surgery instead of osteosynthesis. After the surgery, her upper arm pain and instability immediately improved. Three years after the last surgery, there have been no implant failures, and the upper arm is stable and painless. Conclusion: Although there are some reports of total humerus replacement as surgical treatment for humeral tumor and severe periprosthetic fracture, we found no reports of such ballooning deformity around the nonunion site. Total humerus replacement can be one of the treatment options in cases where nonunion surgery is extremely difficult, depending on the patient's age and activities of daily living.

  Jan. 2022, Journal of orthopaedic case reports, 12(1) (1), 89 - 91, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Treatment of Chronic Osteomyelitis of the Femur by Intramedullary Antibiotic Perfusion (iMAP): A Case Report.

  Keisuke Oe, Akihiro Maruo, Tomoaki Fukui, Hirotsugu Muratsu, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: Chronic osteomyelitis is difficult to cure definitively, because local areas are often covered with sequestrum and scar tissues with a poor blood flow; these may render systemic antibiotic administration ineffective. We present a case of chronic osteomyelitis that was successfully treated with continuous local antibiotic perfusion (CLAP) through an intramedullary antibiotic perfusion (iMAP) pin. CASE PRESENTATION: A 65-year-old man who suffered an episode of the right femoral osteomyelitis at the age of 15 years experienced a relapse at the age of 63 years. Systemic administration of antibiotics could not control the infection; thus, a surgery was performed. A bone marrow needle (i.e., an iMAP pin; diameter: 3 mm) was percutaneously inserted, from the front, distally and proximally to the cystic lesion in the distal femur. After washing through the iMAP pins, the pins were left indwelling. A closed drain tube was placed on the bone surface, which was close to the fistula of the bone marrow lesion. CLAP therapy was then initiated. Gentamicin was continuously infused through the iMAP pin at a rate of 2 mL/h and drained using the tube. Accordingly, 2.4 mg/mL, 1.2 mg/mL, and 1.2 mg/mL of gentamicin were administered for 4 days using two iMAP pins, for 5-8 days using two iMAP pins, and for 9-15 days using one iMAP pin, respectively, with a syringe pump. The iMAP pins and the drain tube were removed 15 days after the initiation of the CLAP therapy. The C-reactive protein level normalized 25 days postoperatively. The patient recovered full range of motion of the knee joint and recreational sports activity without recurrence of osteomyelitis for 5 years after the therapy. CONCLUSIONS: CLAP therapy allows local administration of a sufficient concentration of antibiotics and device removal after treatment is simple. This may be a novel treatment for chronic osteomyelitis.

  Dec. 2021, Journal of orthopaedic case reports, 11(12) (12), 35 - 38, English, International magazine

  Scientific journal


• Treatment of Chronic Osteomyelitis of the Femur by Intramedullary Antibiotic Perfusion (iMAP): A Case Report.

  Keisuke Oe, Akihiro Maruo, Tomoaki Fukui, Hirotsugu Muratsu, Ryosuke Kuroda, Takahiro Niikura

  Introduction: Chronic osteomyelitis is difficult to cure definitively, because local areas are often covered with sequestrum and scar tissues with a poor blood flow; these may render systemic antibiotic administration ineffective. We present a case of chronic osteomyelitis that was successfully treated with continuous local antibiotic perfusion (CLAP) through an intramedullary antibiotic perfusion (iMAP) pin. Case Presentation: A 65-year-old man who suffered an episode of the right femoral osteomyelitis at the age of 15 years experienced a relapse at the age of 63 years. Systemic administration of antibiotics could not control the infection; thus, a surgery was performed. A bone marrow needle (i.e., an iMAP pin; diameter: 3 mm) was percutaneously inserted, from the front, distally and proximally to the cystic lesion in the distal femur. After washing through the iMAP pins, the pins were left indwelling. A closed drain tube was placed on the bone surface, which was close to the fistula of the bone marrow lesion. CLAP therapy was then initiated. Gentamicin was continuously infused through the iMAP pin at a rate of 2 mL/h and drained using the tube. Accordingly, 2.4 mg/mL, 1.2 mg/mL, and 1.2 mg/mL of gentamicin were administered for 4 days using two iMAP pins, for 5-8 days using two iMAP pins, and for 9-15 days using one iMAP pin, respectively, with a syringe pump. The iMAP pins and the drain tube were removed 15 days after the initiation of the CLAP therapy. The C-reactive protein level normalized 25 days postoperatively. The patient recovered full range of motion of the knee joint and recreational sports activity without recurrence of osteomyelitis for 5 years after the therapy. Conclusions: CLAP therapy allows local administration of a sufficient concentration of antibiotics and device removal after treatment is simple. This may be a novel treatment for chronic osteomyelitis.

  Dec. 2021, Journal of orthopaedic case reports, 11(12) (12), 35 - 38, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Low-Intensity Pulsed Ultrasound Promotes Osteogenic Differentiation of Reamer-Irrigator-Aspirator Graft-Derived Cells in Vitro.

  Kenichi Sawauchi, Tomoaki Fukui, Keisuke Oe, Yohei Kumabe, Takahiro Oda, Ryo Yoshikawa, Kyohei Takase, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  Recently, reamer-irrigator-aspirator (RIA) systems have been increasingly used to harvest autologous bone grafts. RIA graft materials contain bone marrow, which provides a viable source to derive large numbers of mesenchymal stem cells. Low-intensity pulsed ultrasound (LIPUS) significantly accelerates the differentiation of stem cells derived from bone marrow. This in vitro study investigated the effect of LIPUS on the osteogenic activity and differentiation of RIA graft-derived cells. A small amount of RIA graft was obtained from seven patients. After the cells derived from RIA grafts were cultured, they were divided into two groups: the LIPUS and control groups. LIPUS was applied once daily for 20 min (1.5 MHz, pulse duration: 200 µs, pulse repetition rate: 1 kHz, spatial average-temporal average intensity: 30 mW/cm2). Alkaline phosphatase activity (113.4% and 130.1% on days 7 and 14), expression of osteoblast-related genes (ALP, Runx2) and mineralization (135.2% on day 21) of the RIA graft-derived cells were significantly higher in the LIPUS group than in the control group. However, LIPUS did not affect the cell proliferation of RIA graft-derived cells. This study indicates that LIPUS may enhance the healing of non-union and critical bone defects treated by autologous bone grafting using the RIA system.

  Nov. 2021, Ultrasound in medicine & biology, 48(2) (2), 313 - 322, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Endochondral Bone Tissue Engineering Using Human Induced Pluripotent Stem Cells.

  Michio Arakura, Sang Yang Lee, Tomoaki Fukui, Keisuke Oe, Shunsuke Takahara, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  The use of induced pluripotent stem cells (iPSCs) shows potential in bone regenerative strategies. In this study, we investigated whether implantation of chondrogenically differentiated iPSC-derived mesenchymal stem cells (iMSCs) can lead to successful bone regeneration in nude mice with bone defects. Two human iPSC clones (201B7 and 454E2) were used. After generating iMSCs, chondrogenic differentiation was achieved by three-dimensional pellet culture. Thereafter, a 2-mm defect was created in the radius of nude mice, and chondrogenically differentiated iMSC pellets were transplanted in the defect. Microcomputed tomography imaging was performed 8 weeks posttransplantation to assess bone regeneration. All (100%) radii in the 201B7 cell-derived pellet transplantation group and 7 of 10 (70%) radii in the 454E2 cell-derived pellet transplantation group showed bone union. In contrast, 2 of 11 radii (18%) in the control group showed bone union. Thus, the experimental groups showed significantly higher bone union rates than the control group (p < 0.05). Histological analysis 2 weeks postimplantation in the experimental groups revealed hypertrophic chondrocytes within grafted iMSC pellets and the formation of woven bone around them. This hypertrophic chondrocyte transitioning to newly formed bone suggests that the cartilaginous template can trigger endochondral bone ossification (ECO). Four weeks postimplantation, the cartilage template was reduced in size; newly formed woven bone was predominant in the defect site. New vessels were surrounded by a matrix of woven bone, and hypertrophic chondrocytes transitioning to newly formed bone indicated the progression of ECO. Eight weeks postimplantation, the pellets were completely resorbed and replaced by bone; complete bone union was observed. Dense mature bone developed with evidence of lamellar-like bone formation. Collectively, our results suggest that using iMSC-based cartilage grafts recapitulating the morphogenetic process of ECO in the context of embryonic skeletogenesis is a promising strategy for repairing large bone defects.

  Sep. 2021, Tissue engineering. Part A, 28(3-4) (3-4), 184 - 195, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Non-hypertrophic nonunion cellsの増殖能・骨分化能に対するE-BMP-2の効果の検討

  吉川 遼, 新倉 隆宏, 福井 友章, 大江 啓介, 高瀬 恭平, 澤内 健一, 小田 崇弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1814 - S1814, Japanese


• Effects of ultrasound, radial extracorporeal shock waves, and electrical stimulation on rat bone defect healing.

  Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama

  Fractures associated with osteoporosis are a major public health concern. Current treatments for fractures are limited to surgery or fixation, leading to long-term bedrest, which is linked to increased mortality. Alternatively, utilization of physical agents has been suggested as a promising therapeutic approach for fractures. Here, we examined the effects of ultrasound, radial extracorporeal shock waves, and electrical stimulation on normal or osteoporotic fracture healing. Femoral bone defects were created in normal or ovariectomized rats. Rats were divided into four groups: untreated, and treated with ultrasound, shock waves, or electrical stimulation after surgery. Samples were collected at 2 or 4 weeks after surgery, and the healing process was evaluated with micro-CT, histological, and immunohistochemical analyses. Ultrasound at intensities of 0.5 and 1.0 W/cm2 , but not 0.05 W/cm2 , accelerated new bone formation. Shock wave exposure also increased newly formed bone, but formed abnormal periosteal callus around the defect site. Conversely, electrical stimulation did not affect the healing process. Ultrasound exposure increased osteoblast activity and cell proliferation and decreased sclerostin-positive osteocytes. We demonstrated that higher-intensity ultrasound and radial extracorporeal shock waves accelerate fracture healing, but shock wave treatment may increase the risk of periosteal callus formation.

  Aug. 2021, Annals of the New York Academy of Sciences, 1497(1) (1), 3 - 14, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Utilization of Mechanical Stress to Treat Osteoporosis: The Effects of Electrical Stimulation, Radial Extracorporeal Shock Wave, and Ultrasound on Experimental Osteoporosis in Ovariectomized Rats.

  Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama

  Current treatment options for osteoporosis primarily involve pharmacotherapies, but they are often accompanied by undesirable side effects. Utilization of mechanical stress which can noninvasively induce bone formation has been suggested as an alternative to conventional treatments. Here, we examined the efficacy of mechanical stress induced by electrical stimulation, radial extracorporeal shock waves, and ultrasound for estrogen-deficient osteoporosis. Female Wistar rats were divided into following five groups: sham-operated group, untreated after ovariectomy, and treated with electrical stimulation, radial extracorporeal shock wave, or ultrasound starting at 8 weeks after ovariectomy for 4 weeks. Trabecular bone architecture of the femur was assessed by micro-CT and its biomechanical properties were obtained by mechanical testing. The femurs were further evaluated by histochemical, immunohistochemical, and real-time PCR analyses. Radial extracorporeal shock wave and ultrasound treatment improved trabecular bone microarchitecture and bone strength in osteoporotic rats, but not electrical stimulation. The shock wave decreased osteoclast activity and RANKL expression. The exposure of ultrasound increased osteoblast activity and β-catenin-positive cells, and they decreased sclerostin-positive osteocytes. These findings suggest that mechanical stress induced by radial extracorporeal shock wave and ultrasound can improve estrogen-deficient bone loss and bone fragility through promoted bone formation or attenuated bone resorption.

  Aug. 2021, Calcified tissue international, 109(2) (2), 215 - 229, English, International magazine

  Scientific journal


• Correction to: Utilization of Mechanical Stress to Treat Osteoporosis: The Effects of Electrical Stimulation, Radial Extracorporeal Shock Wave, and Ultrasound on Experimental Osteoporosis in Ovariectomized Rats.

  Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama

  Aug. 2021, Calcified tissue international, 109(2) (2), 230 - 230, English, International magazine


• Ultrasound Frequency-Based Monitoring for Bone Healing.

  Yohei Kumabe, Keisuke Oe, Masakazu Morimoto, Naomi Yagi, Tomoaki Fukui, Ryosuke Kuroda, Yutaka Hata, Takahiro Niikura

  Correct assessment of the bone healing process is required for the management of limb immobilization during the treatment of bone injuries, including fractures and defects. Although the monitoring of bone healing using ultrasound poses several advantages regarding cost and ionizing radiation exposure compared with other dominant imaging methods, such as radiography and computed tomography (CT), traditional ultrasound B-mode imaging lacks reliability and objectivity. However, the body structures can be quantitatively observed by ultrasound frequency-based methods, and therefore, the disadvantages of B-mode imaging can be overcome. In this study, we created a femoral bone hole model of a rat and observed the bone healing process using the quantitative ultrasound method and micro-CT, which provides a reliable assessment of the tissue microstructure of the bone. This study analyzed the correlation between these two assessments. The results revealed that the quantitative ultrasound measurements correlated with the CT measurements for rat bone healing. This ultrasound frequency-based method could have the potential to serve as a novel modality for quantitative monitoring of bone healing with the advantages of being less invasive and easily accessible. Impact statement Bone healing monitoring with ultrasound is advantageous as it is less invasive and easily accessible; however, the traditional B-mode method lacks reliability and objectivity. This study demonstrated that the proposed ultrasound frequency-based monitoring method can quantitatively observe bone healing and strongly correlates with the computed tomography measurements for rat bone healing. This method has the potential to become a reliable modality for monitoring bone healing.

  Jun. 2021, Tissue engineering. Part C, Methods, 27(6) (6), 349 - 356, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A postoperative displacement measurement method for femoral neck fracture internal fixation implants based on femoral segmentation and multi-resolution frame registration

  Kaifeng Liu, Kouki Nagamune, Keisuke Oe, Ryosuke Kuroda, Takahiro Niikura

  MDPI AG, May 2021, Symmetry, 13(5) (5), English

  Scientific journal


• Clinical experience of the use of reamer irrigator aspirator in Japanese patients: A report of the first 42 cases.

  Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: A reamer irrigator aspirator (RIA) can be used to harvest substantial amounts of autologous bone and debride the intramedullary canal. Clinical experience using reamer irrigator aspirators in Japan is very limited. The applicability of the reamer irrigator aspirator head with a minimum diameter of 12 mm for Japanese people is often questioned as the Japanese are smaller than Americans and Europeans. There are no reports of complications in Japanese patients. This study aimed to retrospectively review clinical cases and describe reamer irrigator aspirator use in Japanese patients. METHODS: All patients for whom a reamer irrigator aspirator was used during surgery at our hospital between January 2014 and September 2018 were included. The patients' clinical and radiographic data were retrospectively reviewed. RESULTS: Data of 40 patients (42 cases) were collected. The reamer irrigator aspirator was used for bone graft harvesting in 32 cases, intramedullary debridement and irrigation in 9 cases, and reaming for exchange nailing in 1 case. The diameter of the reamer irrigator aspirator reamer head was 12 mm in 22 cases (53.7%), 12.5 mm in 4 cases (9.8%), 13 mm in 9 cases (22.0%), 13.5 mm in 1 case (2.4%), 14.0 mm in 1 case (2.4%), 14.5 mm in 1 case (2.4%), and 15 mm in 4 cases (9.8%). Mean intraoperative bleeding volume was 1158.6 mL (range, 100-3800 mL). We experienced no difficulty inserting the reamer irrigator aspirator into the intramedullary canals and no cases of insertion-related intraoperative fracture. Five cortical perforations (11.9%) were observed on postoperative computed tomography scans, although no patient was symptomatic. One case (2.4%) of postoperative femur fracture occurred. CONCLUSIONS: Reamer irrigator aspirators can be used in Japanese patients. Smaller reamer head sizes were mainly used in our experience. We should manage complications as in previous reports from Western countries.

  May 2021, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 26(3) (3), 459 - 465, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Migration Measurement of Pins in Postoperative Recovery of the Proximal Femur Fractures Based on 3D Point Cloud Matching.

  Kaifeng Liu, Kouki Nagamune, Keisuke Oe, Ryosuke Kuroda, Takahiro Niikura

  Background and objectives: Internal fixation is one of the most effective methods for the treatment of proximal femur fractures. The migration of implants after the operation can seriously affect the reduction of treatment and even cause complications. Traditional diagnosis methods can not directly measure the extent of displacement. Methods: Based on the analysis of Hansson pins, this paper proposes a measurement method based on three-dimensional matching, which uses computerized tomography (CT) images of different periods of patients after the operation to analyze the implants' migration in three-dimensional space with the characteristics of fast speed and intuitive results. Results and conclusions: The measurement results show that the method proposed in this paper has more minor errors, more flexible coordinate system conversion, and more explicit displacement analysis than the traditional method of manually finding references in CT images and measuring displacement.

  Apr. 2021, Medicina (Kaunas, Lithuania), 57(5) (5), English, International magazine

  Scientific journal


• Histological analysis of induced membranes in patients whose bone defects were treated with the Masquelet technique to identify factors affecting the vascularity of induced membranes.

  Takahiro Niikura, Naoe Jimbo, Masato Komatsu, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Yoshitada Sakai, Tomoo Itoh, Ryosuke Kuroda

  BACKGROUND: Rich vascularity of the induced membrane (IM) is important for Masquelet reconstruction surgery. The factors affecting IM vascularity are not completely understood. This study aimed to investigate these factors using histological samples of human IMs. METHODS: We retrospectively evaluated 36 patients whose bone defects were treated using the Masquelet technique. Two clinical pathologists analyzed histological sections of IM pieces (1 cm2). The number of blood vessels per 1 mm2 was counted and compared among men and women, femur or tibia, with and without free flap surgery, antibiotic impregnation to the cement, osteogenesis inside the membrane, smoking, and diabetes mellitus. The number of blood vessels within the same patient was compared among different time points. Correlation analysis was performed among blood vessel numbers and patient age, duration of cement spacer placement, and histological grading scales (inflammation, foreign body reaction, and fibrosis). RESULTS: IM formation with rich vascularity and some inflammation, foreign body reaction, and fibrosis were histologically confirmed in all patients. We found 37.4 ± 19.1 blood vessels per 1 mm2. The number of blood vessels was significantly lower in patients with than in those without free flap surgery; it was higher in patients with osteogenesis inside the IM. No significant correlations were found in any of the analyses. CONCLUSION: Sex, patient age, smoking, diabetes mellitus, femur or tibia, duration of cement spacer placement, and antibiotic impregnation to the cement did not affect IM vascularization. IM vascularization was reduced in patients with than in those without free flap surgery.

  Apr. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 248 - 248, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Bilateral Tibial Proximal Fractures Caused by Secondary Osteomalacia due to Autoimmune Polyendocrine Syndrome Type 2: A Case Report.

  Daisuke Nakagawa, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: Hypophosphatemic osteomalacia can be overlooked or confused with other musculoskeletal disorders due to the variety of associated clinical, laboratory, and radiographic findings. If osteomalacia is diagnosed early and the fractures are not displaced, they often heal with nutritional supplements, but, if they progress to displaced fractures, they may require surgical intervention. CASE REPORT: We present a case of secondary osteomalacia due to autoimmune polyendocrine syndrome Type 2 due to this condition, the patient developed bilateral tibial proximal fractures and her varus deformity had progressed. No clear indication of the timing for surgery for adults with osteomalacia has been reported. However, medical treatment improves the symptoms of osteomalacia and it is reported that in children, appropriate level of the serum phosphate (P) should be attained and maintained for the successful bone healing after osteotomy. Therefore, we prioritized pharmacological treatment and prescribed surgery after confirming that the value of serum phosphate P had been improved to recommended levels (2.5-3.5 mg/dl). We performed high tibial osteotomy for the right side and gradual correction by an external fixation for the left tibia, because of more severe deformation, and converted to an internal fixation to shorten the treatment period. During conversion, we performed the operation with a locking plate by the minimal invasive plate osteosynthesis method (MIPO). CONCLUSION: We conclude that the use of different deformity correction methods, depending on the degree of deformity, and the pharmacological treatment of osteomalacia may lead to favorable results.

  Apr. 2021, Journal of orthopaedic case reports, 11(4) (4), 14 - 17, English, International magazine

  Scientific journal


• Bilateral Tibial Proximal Fractures Caused by Secondary Osteomalacia due to Autoimmune Polyendocrine Syndrome Type 2: A Case Report.

  Daisuke Nakagawa, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Takahiro Niikura

  Introduction: Hypophosphatemic osteomalacia can be overlooked or confused with other musculoskeletal disorders due to the variety of associated clinical, laboratory, and radiographic findings. If osteomalacia is diagnosed early and the fractures are not displaced, they often heal with nutritional supplements, but, if they progress to displaced fractures, they may require surgical intervention. Case Report: We present a case of secondary osteomalacia due to autoimmune polyendocrine syndrome Type 2 due to this condition, the patient developed bilateral tibial proximal fractures and her varus deformity had progressed. No clear indication of the timing for surgery for adults with osteomalacia has been reported. However, medical treatment improves the symptoms of osteomalacia and it is reported that in children, appropriate level of the serum phosphate (P) should be attained and maintained for the successful bone healing after osteotomy. Therefore, we prioritized pharmacological treatment and prescribed surgery after confirming that the value of serum phosphate P had been improved to recommended levels (2.5-3.5 mg/dl). We performed high tibial osteotomy for the right side and gradual correction by an external fixation for the left tibia, because of more severe deformation, and converted to an internal fixation to shorten the treatment period. During conversion, we performed the operation with a locking plate by the minimal invasive plate osteosynthesis method (MIPO). Conclusion: We conclude that the use of different deformity correction methods, depending on the degree of deformity, and the pharmacological treatment of osteomalacia may lead to favorable results.

  Apr. 2021, Journal of orthopaedic case reports, 11(4) (4), 14 - 17, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Quantitative bone single-photon emission computed tomography imaging for uninfected nonunion: comparison of hypertrophic nonunion and non-hypertrophic nonunion.

  Keisuke Oe, Feibi Zeng, Tomoaki Fukui, Munenobu Nogami, Takamichi Murakami, Tomoyuki Matsumoto, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Recently, a standardized uptake value (SUV) has been used to evaluate bone single-photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected nonunion to compare hypertrophic nonunion and non-hypertrophic nonunion using volume-based parameters. METHODS: We evaluated 23 patients with uninfected nonunion who underwent SPECT acquisition 3 h after an injection of 99mTc-hydroxymethylene diphosphonate or 99mTc-methylene diphosphonate from April 2014 to November 2019. We reconstructed the acquired data and performed voxel-based quantitative analysis using the GI-BONE software. Quantitative parameters, maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean) in the high and low uptake areas of nonunion were compared between hypertrophic nonunion and non-hypertrophic nonunion. The contralateral limb was used as a control, and the ratios of the quantitative parameters were calculated. RESULTS: The values for the quantitative parameters (high uptake area/low uptake area, respectively), SUVmax control ratio (12.13 ± 4.95/6.44 ± 4.71), SUVpeak control ratio (11.65 ± 4.58/6.45 ± 4.64), and SUVmean control ratio (11.94 ± 5.03/6.28 ± 4.95) for hypertrophic nonunion were higher than those for non-hypertrophic nonunion (7.82 ± 4.76/3.41 ± 2.09 (p = 0.065/0.12), 7.56 ± 4.51/3.61 ± 2.23 (p = 0.065/0.22), and 7.59 ± 5.18/3.05 ± 1.91 (p = 0.076/0.23)). CONCLUSIONS: SUVmax, SUVpeak, and SUVmean control ratios obtained from bone SPECT images can quantitatively evaluate the biological activity of nonunions and may be an effective evaluation method for treatment decisions, especially the necessity of autologous bone grafting.

  Feb. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 125 - 125, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Closed Compression Nailing Using a New-Generation Intramedullary Nail without Autologous Bone Grafting for Humeral Shaft Nonunion.

  Genta Fukumoto, Tomoaki Fukui, Keisuke Oe, Atsuyuki Inui, Yutaka Mifune, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: Although the recommended treatment for humeral shaft nonunion is compression plating with autologous bone grafting, we treated a case of humeral shaft nonunion with an intramedullary nail (IMN) without bone grafting. Presentation of Case. Osteosynthesis with IMN was performed on a 24-year-old man with a humeral shaft fracture at another hospital. However, bony union was not obtained 1 year after the first surgery, and he was referred to our institution. We treated the nonunion with exchange nailing without autologous bone grafting using compression function of the nail, leading to bony union at 7 months postoperatively. At the final follow-up 2 years and 4 months postoperatively, the patient had full range of motion in the left shoulder and elbow joints. Discussion. Compression plating with autologous bone grafting is reported to be the gold standard for the treatment of humeral shaft nonunion. IMN is advantageous for minimal invasion; however, the conventional type of IMN cannot apply compression force between fragments and does not have sufficient stability against rotational force. In this case, we used an IMN that could apply compression between the fragments and which had rotational stability via many screws. We did not perform bone grafting because the current nonunion was adjudged to be biologically active, and we achieved good functional results. CONCLUSION: We treated humeral shaft nonunion using IMN with compression, but without bone grafting, leading to successful clinical outcomes. This strategy might be an appropriate choice for the treatment of humeral shaft nonunion with biological activity.

  2021, Case reports in orthopedics, 2021, 5548729 - 5548729, English, International magazine

  Scientific journal


• A Case of Femoral Neck Insufficiency Fracture due to Tumor-Induced Osteomalacia.

  Yu Inoue, Tomoaki Fukui, Keisuke Oe, Shinya Hayashi, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Tumor-induced osteomalacia (TIO) is a rare skeletal disease caused by hypersecretion of fibroblast growth factor 23 (FGF-23) from neoplasms of mesenchymal origin; patients with TIO present with insufficiency fractures, progressive bone pain, and delayed fracture unions. Herein, we report the case of a 48-year-old man with an insufficiency fracture in his left femoral neck associated with TIO. The causative tumor located in the patient's maxillary sinus had been resected; however, complete resection was impossible due to the location of the tumor. Therefore, the patient's osteomalacia persisted, and he experienced a left femoral neck fracture in the absence of severe trauma. Because delayed fracture union was anticipated in this patient, we performed an internal fixation using an implant with a lateral plate for angular stability and multiple screws for rotational stability. Although fracture union took 15 months, the patient's postoperative course was uneventful, and he could walk without any symptoms or assistance at his most recent follow-up 30 months after surgery. In TIO, hypersecretion of FGF-23 leads to increased renal excretion of phosphorus, increased bone resorption of calcium and phosphorus, decreased osteoblastic bone mineralization, and decreased gastrointestinal absorption of calcium and phosphorus, leading to insufficiency fractures and delayed fracture unions. Diagnosis of TIO is often delayed due to its rarity and vague symptoms. Total resection of the causative tumor is the optimal treatment; however, in cases wherein complete tumor resection is impossible, drug therapy may be insufficient, and the underlying TIO pathology, including bone fragility, may persist. Early diagnosis of TIO is important for preventing insufficiency fractures; however, when fractures are unavoidable, the surgical treatment of femoral neck fractures in patients with osteomalacia should account for a longer time frame for complete fracture union and therefore utilize implants with sufficient stability.

  2021, Case reports in orthopedics, 2021, 6668006 - 6668006, English, International magazine

  Scientific journal


• Intra-medullary antibiotics perfusion (iMAP) for the control of fracture-related infection early after osteosynthesis.

  Akihiro Maruo, Takahiro Oda, Hidetoshi Miya, Hirotsugu Muratsu, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Takahiro Niikura

  PURPOSE: In our hospital, cases of bone and soft tissue infections have been treated with continuous local antibiotics perfusion that allows for continuous circulation of antibiotics throughout the infected lesion. We termed this treatment "intramedullary antibiotics perfusion (iMAP)" for bone infection such as fracture-related infection (FRI) and "intrasoft tissue antibiotics perfusion" for soft tissue infection. Many cases are treated with both modalities. To introduce iMAP, this study focused on the patients with FRI treated with iMAP and reviewed their treatment outcomes. METHODS: We included 10 patients with FRI treated with iMAP between 2004 and 2017. The iMAP needles were inserted near the infected lesion, and an aminoglycoside antimicrobial was continuously administered. Patient characteristics, pathogenic bacteria, administered antibiotics, duration of administration, concentrations of antibiotics in blood and leachate fluid, fracture union rate, implant retention rate, and complications were studied. RESULTS: The mean age of patients was 59.9 years, and the mean follow-up period was 2.5 years. Affected bones were the tibia (n = 8), humerus (n = 1), and fibula (n = 1). Deep infections developed on average 29.9 days after osteosynthesis. Pathogenic bacteria were methicillin-susceptible Staphylococcus aureus (n = 6), methicillin-resistant S. aureus (n = 2), and unknown (n = 2). Average iMAP duration was 17.1 days. In all patients, infection was eradicated while preserving the implants, and fracture union was achieved without complications. CONCLUSION: iMAP is a novel local drug delivery system allowing high concentrations of antibiotics to be administered without complications and is useful in the treatment of FRI.

  2021, Journal of orthopaedic surgery (Hong Kong), 29(3) (3), 23094990211051492 - 23094990211051492, English, International magazine

  Scientific journal


• On Degree of Bone Healing for Bone Fracture Treatment by Ultrasonic Wave.

  Takumi Ueyama, Yohei Kumabe, Keisuke Oe, Tomoaki Fukui, Takahiro Niikura, Ryosuke Kuroda, Masakazu Morimoto, Naomi Yagi, Yutaka Hata

  IEEE, 2021, ICMLC, 1 - 5

  International conference proceedings


• A Case of Femoral Neck Insufficiency Fracture due to Tumor-Induced Osteomalacia.

  Yu Inoue, Tomoaki Fukui, Keisuke Oe, Shinya Hayashi, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Tumor-induced osteomalacia (TIO) is a rare skeletal disease caused by hypersecretion of fibroblast growth factor 23 (FGF-23) from neoplasms of mesenchymal origin; patients with TIO present with insufficiency fractures, progressive bone pain, and delayed fracture unions. Herein, we report the case of a 48-year-old man with an insufficiency fracture in his left femoral neck associated with TIO. The causative tumor located in the patient's maxillary sinus had been resected; however, complete resection was impossible due to the location of the tumor. Therefore, the patient's osteomalacia persisted, and he experienced a left femoral neck fracture in the absence of severe trauma. Because delayed fracture union was anticipated in this patient, we performed an internal fixation using an implant with a lateral plate for angular stability and multiple screws for rotational stability. Although fracture union took 15 months, the patient's postoperative course was uneventful, and he could walk without any symptoms or assistance at his most recent follow-up 30 months after surgery. In TIO, hypersecretion of FGF-23 leads to increased renal excretion of phosphorus, increased bone resorption of calcium and phosphorus, decreased osteoblastic bone mineralization, and decreased gastrointestinal absorption of calcium and phosphorus, leading to insufficiency fractures and delayed fracture unions. Diagnosis of TIO is often delayed due to its rarity and vague symptoms. Total resection of the causative tumor is the optimal treatment; however, in cases wherein complete tumor resection is impossible, drug therapy may be insufficient, and the underlying TIO pathology, including bone fragility, may persist. Early diagnosis of TIO is important for preventing insufficiency fractures; however, when fractures are unavoidable, the surgical treatment of femoral neck fractures in patients with osteomalacia should account for a longer time frame for complete fracture union and therefore utilize implants with sufficient stability.

  2021, Case reports in orthopedics, 2021, 6668006 - 6668006, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 【超音波による骨折治療】偽関節に対する超音波治療

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  金原出版(株), Jan. 2021, 整形・災害外科, 64(1) (1), 61 - 69, Japanese


• Closed Compression Nailing Using a New-Generation Intramedullary Nail without Autologous Bone Grafting for Humeral Shaft Nonunion.

  Genta Fukumoto, Tomoaki Fukui, Keisuke Oe, Atsuyuki Inui, Yutaka Mifune, Ryosuke Kuroda, Takahiro Niikura

  Introduction: Although the recommended treatment for humeral shaft nonunion is compression plating with autologous bone grafting, we treated a case of humeral shaft nonunion with an intramedullary nail (IMN) without bone grafting. Presentation of Case. Osteosynthesis with IMN was performed on a 24-year-old man with a humeral shaft fracture at another hospital. However, bony union was not obtained 1 year after the first surgery, and he was referred to our institution. We treated the nonunion with exchange nailing without autologous bone grafting using compression function of the nail, leading to bony union at 7 months postoperatively. At the final follow-up 2 years and 4 months postoperatively, the patient had full range of motion in the left shoulder and elbow joints. Discussion. Compression plating with autologous bone grafting is reported to be the gold standard for the treatment of humeral shaft nonunion. IMN is advantageous for minimal invasion; however, the conventional type of IMN cannot apply compression force between fragments and does not have sufficient stability against rotational force. In this case, we used an IMN that could apply compression between the fragments and which had rotational stability via many screws. We did not perform bone grafting because the current nonunion was adjudged to be biologically active, and we achieved good functional results. Conclusion: We treated humeral shaft nonunion using IMN with compression, but without bone grafting, leading to successful clinical outcomes. This strategy might be an appropriate choice for the treatment of humeral shaft nonunion with biological activity.

  2021, Case reports in orthopedics, 2021, 5548729 - 5548729, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Transcutaneous CO2 application accelerates fracture repair in streptozotocin-induced type I diabetic rats.

  Takahiro Oda, Takahiro Niikura, Tomoaki Fukui, Keisuke Oe, Yu Kuroiwa, Yohei Kumabe, Kenichi Sawauchi, Ryo Yoshikawa, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Teruya Kawamoto, Yoshitada Sakai, Toshihiro Akisue, Ryosuke Kuroda

  INTRODUCTION: Diabetes mellitus (DM) negatively affects fracture repair by inhibiting endochondral ossification, chondrogenesis, callus formation, and angiogenesis. We previously reported that transcutaneous CO2 application accelerates fracture repair by promoting endochondral ossification and angiogenesis. The present study aimed to determine whether CO2 treatment would promote fracture repair in cases with type I DM. RESEARCH DESIGN AND METHODS: A closed femoral shaft fracture was induced in female rats with streptozotocin-induced type I DM. CO2 treatment was performed five times a week for the CO2 group. Sham treatment, where CO2 was replaced with air, was performed for the control group. Radiographic, histologic, genetic, and biomechanical measurements were taken at several time points. RESULTS: Radiographic assessment demonstrated that fracture repair was induced in the CO2 group. Histologically, accelerated endochondral ossification and capillary formation were observed in the CO2 group. Immunohistochemical assessment indicated that early postfracture proliferation of chondrocytes in callus was enhanced in the CO2 group. Genetic assessment results suggested that cartilage and bone formation, angiogenesis, and vasodilation were upregulated in the CO2 group. Biomechanical assessment revealed enhanced mechanical strength in the CO2 group. CONCLUSIONS: Our findings suggest that CO2 treatment accelerates fracture repair in type I DM rats. CO2 treatment could be an effective strategy for delayed fracture repair due to DM.

  Dec. 2020, BMJ open diabetes research & care, 8(2) (2), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Ultrasonic Diagnosis for Bone Fracture Healing Process

  Satoshi Kimura, Keisuke Oe, Yohei Kumabe, Tomoaki Fukui, Takahiro Niikura, Ryosuke Kuroda, Naomi Yagi, Yutaka Hata

  IEEE, Nov. 2020, 2020 IEEE 50th International Symposium on Multiple-Valued Logic (ISMVL)

  International conference proceedings


• Effects of the duration of transcutaneous CO2 application on the facilitatory effect in rat fracture repair.

  Takahiro Oda, Takashi Iwakura, Tomoaki Fukui, Keisuke Oe, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Teruya Kawamoto, Yoshitada Sakai, Toshihiro Akisue, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Carbon dioxide therapy has been reported to be effective in treating certain cardiac diseases and skin problems. Although a previous study suggested that transcutaneous carbon dioxide application accelerated fracture repair in association with promotion of angiogenesis, blood flow, and endochondral ossification, the influence of the duration of carbon dioxide application on fracture repair is unknown. The aim of this study was to investigate the effect of the duration of transcutaneous carbon dioxide application on rat fracture repair. METHODS: A closed femoral shaft fracture was created in each rat. Animals were randomly divided into four groups: the control group; 1w-CO2 group, postoperative carbon dioxide treatment for 1 week; 2w-CO2 group, postoperative carbon dioxide treatment for 2 weeks; 3w-CO2 group, postoperative carbon dioxide treatment for 3 weeks. Transcutaneous carbon dioxide application was performed five times a week in the carbon dioxide groups. Sham treatment, where the carbon dioxide was replaced with air, was performed for the control group. Radiographic, histological, and biomechanical assessments were performed at 3 weeks after fracture. RESULTS: The fracture union rate was significantly higher in the 3w-CO2 group than in the control group (p < 0.05). Histological assessment revealed promotion of endochondral ossification in the 3w-CO2 group than in the control group. In the biomechanical assessment, all evaluation items related to bone strength were significantly higher in the 3w-CO2 group than in the control group (p < 0.05). CONCLUSIONS: The present study, conducted using an animal model, demonstrated that continuous carbon dioxide application throughout the process of fracture repair was effective in enhancing fracture healing.

  Sep. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(5) (5), 886 - 891, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Infected Gustilo IIIB open knee joint fracture treated with an antimicrobial iodine-supported megaprosthesis: A case report.

  Shin Osawa, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Hiroyuki Tsuchiya, Takahiro Niikura

  Aug. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 28(2) (2), 495 - 498, English, Domestic magazine

  Link to Kobe Univ. Repository (Kernel)


• Percutaneous CO2Treatment Accelerates Bone Generation during Distraction Osteogenesis in Rabbits

  Yohei Kumabe, Tomoaki Fukui, Shunsuke Takahara, Yu Kuroiwa, Michio Arakura, Keisuke Oe, Takahiro Oda, Kenichi Sawauchi, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  Aug. 2020, Clinical Orthopaedics and Related Research, 478(8) (8), 1922 - 1935

  Scientific journal


• Percutaneous CO2 Treatment Accelerates Bone Generation During Distraction Osteogenesis in Rabbits.

  Yohei Kumabe, Tomoaki Fukui, Shunsuke Takahara, Yu Kuroiwa, Michio Arakura, Keisuke Oe, Takahiro Oda, Kenichi Sawauchi, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Distraction osteogenesis has been broadly used to treat various structural bone deformities and defects. However, prolonged healing time remains a major problem. Various approaches including the use of low-intensity pulsed ultrasound, parathyroid hormone, and bone morphogenetic proteins (BMPs) have been studied to shorten the treatment period with limited success. Our previous studies of rats have reported that the transcutaneous application of CO2 accelerates fracture repair and bone-defect healing in rats by promoting angiogenesis, blood flow, and endochondral ossification. This therapy may also accelerate bone generation during distraction osteogenesis, but, to our knowledge, no study investigating CO2 therapy on distraction osteogenesis has been reported. QUESTIONS/PURPOSES: We aimed to investigate the effect of transcutaneous CO2 during distraction osteogenesis in rabbits, which are the most suitable animal as a distraction osteogenesis model for a lengthener in terms of limb size. We asked: Does transcutaneous CO2 during distraction osteogenesis alter (1) radiographic bone density in the distraction gap during healing; (2) callus parameters, including callus bone mineral content, volumetric bone mineral density, and bone volume fraction; (3) the newly formed bone area, cartilage area, and angiogenesis, as well as the expression of interleukin-6 (IL-6), BMP-2, BMP-7, hypoxia-inducible factor (HIF) -1α, and vascular endothelial growth factor (VEGF); and (4) three-point bend biomechanical strength, stiffness, and energy? METHODS: Forty 24-week-old female New Zealand white rabbits were used according to a research protocol approved by our institutional ethical committee. A distraction osteogenesis rabbit tibia model was created as previously described. Briefly, an external lengthener was applied to the right tibia, and a transverse osteotomy was performed at the mid-shaft. The osteotomy stumps were connected by adjusting the fixator to make no gap. After a 7-day latency phase, distraction was continued at 1 mm per day for 10 days. Beginning the day after the osteotomy, a 20-minute transcutaneous application of CO2 on the operated leg using a CO2 absorption-enhancing hydrogel was performed five times per week in the CO2 group (n = 20). Sham treatment with air was administered in the control group (n = 20). Animals were euthanized immediately after the distraction period (n = 10), 2 weeks (n = 10), and 4 weeks (n = 20) after completion of distraction. We performed bone density quantification on the plain radiographs to evaluate consolidation in the distraction gap with image analyzing software. Callus parameters were measured with micro-CT to assess callus microstructure. The newly formed bone area and cartilage area were measured histologically with safranin O/fast green staining to assess the progress of ossification. We also performed immunohistochemical staining of endothelial cells with fluorescein-labeled isolectin B4 and examined capillary density to evaluate angiogenesis. Gene expressions in newly generated callus were analyzed by real-time polymerase chain reaction. Biomechanical strength, stiffness, and energy were determined from a three-point bend test to assess the mechanical strength of the callus. RESULTS: Radiographs showed higher pixel values in the distracted area in the CO2 group than the control group at Week 4 of the consolidation phase (0.98 ± 0.11 [95% confidence interval 0.89 to 1.06] versus 1.19 ± 0.23 [95% CI 1.05 to 1.34]; p = 0.013). Micro-CT demonstrated that bone volume fraction in the CO2 group was higher than that in the control group at Week 4 (5.56 ± 3.21 % [95% CI 4.32 to 6.12 %] versus 11.90 ± 3.33 % [95% CI 9.63 to 14.25 %]; p = 0.035). There were no differences in any other parameters (that is, callus bone mineral content at Weeks 2 and 4; volumetric bone mineral density at Weeks 2 and 4; bone volume fraction at Week 2). At Week 2, rabbits in the CO2 group had a larger cartilage area compared with those in the control group (2.09 ± 1.34 mm [95% CI 1.26 to 2.92 mm] versus 5.10 ± 3.91 mm [95% CI 2.68 to 7.52 mm]; p = 0.011). More newly formed bone was observed in the CO2 group than the control group at Week 4 (68.31 ± 16.32 mm [95% CI 58.19 to 78.44 mm] versus 96.26 ± 19.37 mm [95% CI 84.25 to 108.26 mm]; p < 0.001). There were no differences in any other parameters (cartilage area at Weeks 0 and 4; newly formed bone area at Weeks 0 and 2). Immunohistochemical isolectin B4 staining showed greater capillary densities in rabbits in the CO2 group than the control group in the distraction area at Week 0 and surrounding tissue at Weeks 0 and 2 (distraction area at Week 0, 286.54 ± 61.55 /mm [95% CI 232.58 to 340.49] versus 410.24 ± 55.29 /mm [95% CI 361.78 to 458.71]; p < 0.001; surrounding tissue at Week 0 395.09 ± 68.16/mm [95% CI 335.34 to 454.83] versus 589.75 ± 174.42/mm [95% CI 436.86 to 742.64]; p = 0.003; at Week 2 271.22 ± 169.42 /mm [95% CI 122.71 to 419.73] versus 508.46 ± 49.06/mm [95% CI 465.45 to 551.47]; p < 0.001 respectively). There was no difference in the distraction area at Week 2. The expressions of BMP -2 at Week 2, HIF1-α at Week 2 and VEGF at Week 0 and 2 were greater in the CO2 group than in the control group (BMP -2 at Week 2 3.84 ± 0.83 fold [95% CI 3.11 to 4.58] versus 7.32 ± 1.63 fold [95% CI 5.88 to 8.75]; p < 0.001; HIF1-α at Week 2, 10.49 ± 2.93 fold [95% CI 7.91 to 13.06] versus 20.74 ± 11.01 fold [95% CI 11.09 to 30.40]; p < 0.001; VEGF at Week 0 4.80 ± 1.56 fold [95% CI 3.43 to 6.18] versus 11.36 ± 4.82 fold [95% CI 7.13 to 15.59]; p < 0.001; at Week 2 31.52 ± 8.26 fold [95% CI 24.27 to 38.76] versus 51.05 ± 15.52 fold [95% CI 37.44 to 64.66]; p = 0.034, respectively). There were no differences in any other parameters (BMP-2 at Week 0 and 4; BMP -7 at Weeks 0, 2 and 4; HIF-1α at Weeks 0 and 4; IL-6 at Weeks 0, 2 and 4; VEGF at Week 4). In the biomechanical assessment, ultimate stress and failure energy were greater in the CO2 group than in the control group at Week 4 (ultimate stress 259.96 ± 74.33 N [95% CI 167.66 to 352.25] versus 422.45 ± 99.32 N [95% CI 299.13 to 545.77]; p < 0.001, failure energy 311.32 ± 99.01 Nmm [95% CI 188.37 to 434.25] versus 954.97 ± 484.39 Nmm [95% CI 353.51 to 1556.42]; p = 0.003, respectively). There was no difference in stiffness (216.77 ± 143.39 N/mm [95% CI 38.73 to 394.81] versus 223.68 ± 122.17 N/mm [95% CI 71.99 to 375.37]; p = 0.92). CONCLUSION: Transcutaneous application of CO2 accelerated bone generation in a distraction osteogenesis model of rabbit tibias. As demonstrated in previous studies, CO2 treatment might affect bone regeneration in distraction osteogenesis by promoting angiogenesis, blood flow, and endochondral ossification. CLINICAL RELEVANCE: The use of the transcutaneous application of CO2 may open new possibilities for shortening healing time in patients with distraction osteogenesis. However, a deeper insight into the mechanism of CO2 in the local tissue is required before it can be used in future clinical practice.

  Aug. 2020, Clinical orthopaedics and related research, 478(8) (8), 1922 - 1935, English, International magazine

  Scientific journal


• Subcapital Fracture with Avascular Necrosis of the Whole Femoral Head After Fixation of an Intertrochanteric Fracture: A Case Report.

  Natsuko Fukuoka, Keisuke Oe, Atsushi Sakurai, Takahiro Niikura, Ryosuke Kuroda, Tetsuji Yamamoto

  INTRODUCTION: Subcapital fractures following internal fixation of an intertrochanteric fracture are relatively rare. It has been reported that these fractures are caused by improper placement of implants, osteoporosis, and any trauma episode. We report a rare case of subcapsular fracture possibly caused by whole femoral head necrosis following intertrochanteric fracture treatment. CASE REPORT: An 88-year-old woman fell and sustained an intertrochanteric fracture of the left femur. She was treated with a short femoral nail (SFN) and 3 months after the surgery, bone union was observed. One year after the internal fixation of the intertrochanteric fracture, she complained of the left hip joint pain without any trauma, and the X-ray showed a subcapital fracture of the femur. She underwent nail removal and was treated with a bipolar hemiarthroplasty. Magnetic resonance imaging showed a change in the signal intensity of the entire head, and pathological findings revealed osteonecrosis. Normally, the reaction of bone resorption occurs below the necrosis area. We believe that the avascular necrosis (AVN) of the whole femoral head made the subcapital area fragile, resulting in a subcapital fracture. CONCLUSIONS: We should consider AVN of the whole femoral head as a potential cause of subcapital fracture after SFN fixation of intertrochanteric fractures.

  Jul. 2020, Journal of orthopaedic case reports, 10(4) (4), 42 - 44, English, International magazine

  Scientific journal


• Subcapital Fracture with Avascular Necrosis of the Whole Femoral Head After Fixation of an Intertrochanteric Fracture: A Case Report.

  Natsuko Fukuoka, Keisuke Oe, Atsushi Sakurai, Takahiro Niikura, Ryosuke Kuroda, Tetsuji Yamamoto

  Introduction: Subcapital fractures following internal fixation of an intertrochanteric fracture are relatively rare. It has been reported that these fractures are caused by improper placement of implants, osteoporosis, and any trauma episode. We report a rare case of subcapsular fracture possibly caused by whole femoral head necrosis following intertrochanteric fracture treatment. Case Report: An 88-year-old woman fell and sustained an intertrochanteric fracture of the left femur. She was treated with a short femoral nail (SFN) and 3 months after the surgery, bone union was observed. One year after the internal fixation of the intertrochanteric fracture, she complained of the left hip joint pain without any trauma, and the X-ray showed a subcapital fracture of the femur. She underwent nail removal and was treated with a bipolar hemiarthroplasty. Magnetic resonance imaging showed a change in the signal intensity of the entire head, and pathological findings revealed osteonecrosis. Normally, the reaction of bone resorption occurs below the necrosis area. We believe that the avascular necrosis (AVN) of the whole femoral head made the subcapital area fragile, resulting in a subcapital fracture. Conclusions: We should consider AVN of the whole femoral head as a potential cause of subcapital fracture after SFN fixation of intertrochanteric fractures.

  Jul. 2020, Journal of orthopaedic case reports, 10(4) (4), 42 - 44, English, International magazine


• Altered microRNA profile during fracture healing in rats with diabetes.

  Shunsuke Takahara, Sang Yang Lee, Takashi Iwakura, Keisuke Oe, Tomoaki Fukui, Etsuko Okumachi, Michio Arakura, Yoshitada Sakai, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that regulate gene expression. There is increasing evidence that some miRNAs are involved in the pathology of diabetes mellitus (DM) and its complications. We hypothesized that the functions of certain miRNAs and the changes in their patterns of expression may contribute to the pathogenesis of impaired fractures due to DM. METHODS: In this study, 108 male Sprague-Dawley rats were divided into DM and control groups. DM rats were created by a single intravenous injection of streptozotocin. Closed transverse femoral shaft fractures were created in both groups. On post-fracture days 5, 7, 11, 14, 21, and 28, miRNA was extracted from the newly generated tissue at the fracture site. Microarray analysis was conducted with miRNA samples from each group on post-fracture days 5 and 11. The microarray findings were validated by real-time polymerase chain reaction (PCR) analysis at each time point. RESULTS: Microarray analysis revealed that, on days 5 and 11, 368 and 207 miRNAs, respectively, were upregulated in the DM group, compared with the control group. The top four miRNAs on day 5 were miR-339-3p, miR451-5p, miR-532-5p, and miR-551b-3p. The top four miRNAs on day 11 were miR-221-3p, miR376a-3p, miR-379-3p, and miR-379-5p. Among these miRNAs, miR-221-3p, miR-339-3p, miR-376a-3p, miR-379-5p, and miR-451-5p were validated by real-time PCR analysis. Furthermore, PCR analysis revealed that these five miRNAs were differentially expressed with dynamic expression patterns during fracture healing in the DM group, compared with the control group. CONCLUSIONS: Our findings will aid in understanding the pathology of impaired fracture healing in DM and may support the development of molecular therapies using miRNAs for the treatment of impaired fracture healing in patients with DM.

  Apr. 2020, Journal of orthopaedic surgery and research, 15(1) (1), 135 - 135, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Transcutaneous carbon dioxide application inhibits muscle atrophy after fracture in rats.

  Miho Inoue, Yoshitada Sakai, Keisuke Oe, Takeshi Ueha, Takaaki Koga, Hanako Nishimoto, Shiho Akahane, Risa Harada, Sang Yang Lee, Takahiro Niikura, Ryosuke Kuroda

  BACKGROUND: Muscle atrophy causes difficulty in resuming daily activities after a fracture. Because transcutaneous carbon dioxide (CO2) application has previously upregulated oxygen pressure in the local tissue, thereby demonstrating its potential in preventing muscle atrophy, here we investigated effects of CO2 application on muscle atrophy after femoral shaft fracture. METHODS: Thirty fracture model rats were produced and randomly divided into a no treatment (control group) and treatment (CO2 group) groups. After treatment, the soleus muscle was dissected at post-fracture days 0, 14, and 21. Evaluations were performed by measuring muscle weight and performing histological examination and gene expression analysis. RESULTS: Muscle weight was significantly higher in the CO2 group than in the control group. Histological analysis revealed that the muscle fiber cross-sectional area was reduced in both groups. Nevertheless, the extent of atrophy was lesser in the CO2 group. Muscle fibers in the control group tended to change into fast muscle fibers. Vascular staining revealed that more capillary vessels surrounded the muscle fibers in the CO2 group than in the control group. Messenger RNA (mRNA) analysis revealed that the CO2 group had a significantly enhanced expression of genes that were related to muscle synthesis. CONCLUSION: Transcutaneous CO2 application may be a novel therapeutic strategy for preventing skeletal muscle atrophy after fracture.

  Mar. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(2) (2), 338 - 343, English, Domestic magazine

  [Refereed]

  Scientific journal


• Limb Salvage for a Mangled Foot: A Case Report.

  Takahiro Oda, Keisuke Oe, Atsushi Sakurai, Tomoaki Fukui, Takahiro Niikura, Ryosuke Kuroda

  INTRODUCTION: It remains controversial whether amputation or limb salvage is the best approach for mangled foot cases because there are no clear criteria for treatment. We report a case of successful limb salvage for a mangled foot, with good outcomes. CASE REPORT: The patient was a 30-year-old man who sustained a crush injury to his left foot and ankle and lower legs in a car crash; he had severe open left foot and ankle fracture and bilateral open tibial shaft fractures. Blood flow was maintained by the posterior tibial artery, and the tibial nerve was intact. We stabilized the ankle using Kirschner wires on the day of injury. Plastic surgeons were consulted for early soft tissue coverage. Final fixation was performed 12 weeks after flap grafting; we grafted an autologous bone on the defect, according to the Masquelet technique. Four months after the final surgery, fullweightbearing gait was initiated. The patient is now capable of walking independently, with no pain, and is highly satisfied. CONCLUSIONS: Limb salvage can be successfully performed even in a patient with a severely mangled foot. For successful salvage surgery with good outcomes, such patients should be managed by a team of experienced orthopedic and plastic surgeons from an early stage to achieve appropriate bone alignment and soft tissue coverage.

  2020, Journal of orthopaedic case reports, 9(6) (6), 58 - 61, English, International magazine

  Scientific journal


• Surgically Treated Nonunion following Ischial Tuberosity Avulsion Fracture of a 14-Year-Old Athlete.

  Yuta Nakamatsu, Tomoaki Fukui, Keisuke Oe, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  A 14-year-old girl experienced acute left buttock pain during a sprint. At the local hospital, she was diagnosed with an avulsion fracture of the left ischial tuberosity. She was kept for observation for about 10 months; however, the buttock pain persisted, and the bone fragments did not unite. She was referred to our hospital approximately 11 months after the injury. Plain radiography revealed an increased transposition of the bone fragment, from 12 mm immediately after the injury to 23 mm. Twelve months after the injury, she underwent osteosynthesis using two cannulated cancellous screws and three suture anchors. Following postoperative rehabilitation, the power in her left hamstring recovered, and she was able to run at full speed and returned to athletics 9 months after the surgery. The operative indications for avulsion fractures of the ischial tuberosity are unclear. Careful follow-up is required as the rate of nonunion after conservative treatment tends to be high. This needs to be identified in order to provide timely treatment that allows for early return to sport. Although she had significant chronic pain and muscle weakness, the surgery successfully treated the fracture, and her muscle power recovered, leading to her return to sports.

  2020, Case reports in orthopedics, 2020, 8531648 - 8531648, English, International magazine

  Scientific journal


• Limb Salvage for a Mangled Foot: A Case Report.

  Takahiro Oda, Keisuke Oe, Atsushi Sakurai, Tomoaki Fukui, Takahiro Niikura, Ryosuke Kuroda

  Introduction: It remains controversial whether amputation or limb salvage is the best approach for mangled foot cases because there are no clear criteria for treatment. We report a case of successful limb salvage for a mangled foot, with good outcomes. Case Report: The patient was a 30-year-old man who sustained a crush injury to his left foot and ankle and lower legs in a car crash; he had severe open left foot and ankle fracture and bilateral open tibial shaft fractures. Blood flow was maintained by the posterior tibial artery, and the tibial nerve was intact. We stabilized the ankle using Kirschner wires on the day of injury. Plastic surgeons were consulted for early soft tissue coverage. Final fixation was performed 12 weeks after flap grafting; we grafted an autologous bone on the defect, according to the Masquelet technique. Four months after the final surgery, fullweightbearing gait was initiated. The patient is now capable of walking independently, with no pain, and is highly satisfied. Conclusions: Limb salvage can be successfully performed even in a patient with a severely mangled foot. For successful salvage surgery with good outcomes, such patients should be managed by a team of experienced orthopedic and plastic surgeons from an early stage to achieve appropriate bone alignment and soft tissue coverage.

  2020, Journal of orthopaedic case reports, 9(6) (6), 58 - 61, English, International magazine


• Surgically Treated Nonunion following Ischial Tuberosity Avulsion Fracture of a 14-Year-Old Athlete.

  Yuta Nakamatsu, Tomoaki Fukui, Keisuke Oe, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  A 14-year-old girl experienced acute left buttock pain during a sprint. At the local hospital, she was diagnosed with an avulsion fracture of the left ischial tuberosity. She was kept for observation for about 10 months; however, the buttock pain persisted, and the bone fragments did not unite. She was referred to our hospital approximately 11 months after the injury. Plain radiography revealed an increased transposition of the bone fragment, from 12 mm immediately after the injury to 23 mm. Twelve months after the injury, she underwent osteosynthesis using two cannulated cancellous screws and three suture anchors. Following postoperative rehabilitation, the power in her left hamstring recovered, and she was able to run at full speed and returned to athletics 9 months after the surgery. The operative indications for avulsion fractures of the ischial tuberosity are unclear. Careful follow-up is required as the rate of nonunion after conservative treatment tends to be high. This needs to be identified in order to provide timely treatment that allows for early return to sport. Although she had significant chronic pain and muscle weakness, the surgery successfully treated the fracture, and her muscle power recovered, leading to her return to sports.

  2020, Case reports in orthopedics, 2020, 8531648 - 8531648, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Exploratory clinical trial on the safety and bactericidal effect of 222-nm ultraviolet C irradiation in healthy humans.

  Tomoaki Fukui, Takahiro Niikura, Takahiro Oda, Yohei Kumabe, Hiroyuki Ohashi, Masahiro Sasaki, Tatsushi Igarashi, Makoto Kunisada, Nozomi Yamano, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Shinya Hayashi, Chikako Nishigori, Ryosuke Kuroda

  INTRODUCTION: Surgical site infection is one of the most severe complications of surgical treatments. However, the optimal procedure to prevent such infections remains uninvestigated. Ultraviolet radiation C (UVC) with a short wavelength has a high bactericidal effect; however, it is cytotoxic. Nonetheless, given that UVC with a wavelength of 222 nm reaches only the stratum corneum, it does not affect the skin cells. This study aimed to investigate the safety of 222-nm UVC irradiation and to examine its skin sterilization effect in healthy volunteers. METHODS: This trial was conducted on 20 healthy volunteers. The back of the subject was irradiated with 222-nm UVC at 50-500 mJ/cm2, and the induced erythema (redness of skin) was evaluated. Subsequently, the back was irradiated with a maximum amount of UVC not causing erythema, and the skin swabs before and after the irradiation were cultured. The number of colonies formed after 24 hours was measured. In addition, cyclobutene pyrimidine dimer (CPD) as an indicator of DNA damage was measured using skin tissues of the nonirradiated and irradiated regions. RESULTS: All subjects experienced no erythema at all doses. The back of the subject was irradiated at 500 mJ/cm2, and the number of bacterial colonies in the skin swab culture was significantly decreased by 222-nm UVC irradiation. The CPD amount produced in the irradiated region was slightly but significantly higher than that of the non-irradiated region. CONCLUSION: A 222-nm UVC at 500 mJ/cm2 was a safe irradiation dose and possessed bactericidal effects. In the future, 222-nm UVC irradiation is expected to contribute to the prevention of perioperative infection.

  2020, PloS one, 15(8) (8), e0235948, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Ras associated with diabetes may play a role in fracture nonunion development in rats.

  Takahiro Oda, Takahiro Niikura, Tomoaki Fukui, Michio Arakura, Keisuke Oe, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Rad is the prototypic member of a subfamily of Ras-related small G-proteins and is highly expressed in the skeletal muscle of patients with type II diabetes. Our previous microarray analysis suggested that Rad may mediate fracture nonunion development. Thus, the present study used rat experimental models to investigate and compare the gene and protein expression patterns of both Rad and Rem1, another RGK subfamily member, in nonunions and standard healing fractures. METHODS: Standard healing fractures and nonunions (produced via periosteal cauterization at the fracture site) were created in the femurs of 3-month-old male Sprague-Dawley rats. At post-fracture days 7, 14, 21, and 28, the fracture callus and fibrous tissue from the standard healing fractures and nonunions, respectively, were harvested and screened (via real-time PCR) for Rad and Rem1 expression. The immunolocalization of both encoded proteins was analyzed at post-fracture days 14 and 21. At the same time points, hematoxylin and eosin staining was performed to identify the detailed tissue structures. RESULTS: Results of real-time PCR analysis showed that Rad expression increased significantly in the nonunions, compared to that in the standard healing fractures, at post-fracture days 14, 21, and 28. Conversely, immunohistochemical analysis revealed the immunolocalization of Rad to be similar to that of Rem1 in both fracture types at post-fracture days 14 and 21. CONCLUSIONS: Rad may mediate nonunion development, and thus, may be a promising therapeutic target to treat these injuries.

  Dec. 2019, BMC musculoskeletal disorders, 20(1) (1), 602 - 602, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Minimally invasive plate osteosynthesis for humeral shaft nonunion: A report of two cases.

  Yoshihito Suda, Keisuke Oe, Tomoaki Fukui, Yutaka Mifune, Atsuyuki Inui, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Introduction: We treated two cases of humeral shaft nonunion by minimally invasive plate osteosynthesis (MIPO) without autogenous bone grafting. Presntation of case: Case 1: An osteosynthesis with intramedullary nailing (IMN) was performed on a 17-year-old female for a humeral shaft fracture at another hospital; however, bony union was not obtained. We removed the nail and screws, then performed MIPO without autogenous bone grafting. At the final follow-up of 4 years after the surgery, she had obtained full range of motion.Case 2: Osteosynthesis with Rush pins had been performed in a 73-year-old female for a humeral shaft fracture at another hospital. Five months later, a revision surgery using IMN was performed at the same hospital; however, this led to nonunion. We removed the IMN and performed MIPO without autogenous bone grafting. At the final follow-up 2 years after surgery, she had obtained full range of motion. Discussion: The cause of nonunion is the lack of mechanical instability and/or biological activity. In these cases, from the findings of radiography and bone scintigraphy, mechanical instability was thought to be the primary cause; therefore, in order to enhance stability, we used a locking plate. Because we can see that these cases are biologically active, we decided not to use bone grafting. Both our cases successfully achieved bony union and excellent functional recovery using this method. Conclusion: We performed MIPO without exposure of the nonunion site and autogenous bone grafting in two cases of humeral shaft nonunion, and obtained successful clinical outcomes.

  Dec. 2019, Annals of medicine and surgery (2012), 48, 43 - 47, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Minimally invasive plate osteosynthesis for humeral shaft nonunion: A report of two cases.

  Yoshihito Suda, Keisuke Oe, Tomoaki Fukui, Yutaka Mifune, Atsuyuki Inui, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: We treated two cases of humeral shaft nonunion by minimally invasive plate osteosynthesis (MIPO) without autogenous bone grafting. PRESNTATION OF CASE: Case 1: An osteosynthesis with intramedullary nailing (IMN) was performed on a 17-year-old female for a humeral shaft fracture at another hospital; however, bony union was not obtained. We removed the nail and screws, then performed MIPO without autogenous bone grafting. At the final follow-up of 4 years after the surgery, she had obtained full range of motion.Case 2: Osteosynthesis with Rush pins had been performed in a 73-year-old female for a humeral shaft fracture at another hospital. Five months later, a revision surgery using IMN was performed at the same hospital; however, this led to nonunion. We removed the IMN and performed MIPO without autogenous bone grafting. At the final follow-up 2 years after surgery, she had obtained full range of motion. DISCUSSION: The cause of nonunion is the lack of mechanical instability and/or biological activity. In these cases, from the findings of radiography and bone scintigraphy, mechanical instability was thought to be the primary cause; therefore, in order to enhance stability, we used a locking plate. Because we can see that these cases are biologically active, we decided not to use bone grafting. Both our cases successfully achieved bony union and excellent functional recovery using this method. CONCLUSION: We performed MIPO without exposure of the nonunion site and autogenous bone grafting in two cases of humeral shaft nonunion, and obtained successful clinical outcomes.

  Dec. 2019, Annals of medicine and surgery (2012), 48, 43 - 47, English, International magazine

  Scientific journal


• Topical cutaneous application of carbon dioxide via a hydrogel for improved fracture repair: results of phase I clinical safety trial.

  Takahiro Niikura, Takashi Iwakura, Takashi Omori, Sang Yang Lee, Yoshitada Sakai, Toshihiro Akisue, Keisuke Oe, Tomoaki Fukui, Takehiko Matsushita, Tomoyuki Matsumoto, Ryosuke Kuroda

  BACKGROUND: Clinicians have very limited options to improve fracture repair. Therefore, it is critical to develop a new clinically available therapeutic option to assist fracture repair biologically. We previously reported that the topical cutaneous application of carbon dioxide (CO2) via a CO2 absorption-enhancing hydrogel accelerates fracture repair in rats by increasing blood flow and angiogenesis and promoting endochondral ossification. The aim of this study was to assess the safety and efficacy of CO2 therapy in patients with fractures. METHODS: Patients with fractures of the femur and tibia were prospectively enrolled into this study with ethical approval and informed consent. The CO2 absorption-enhancing hydrogel was applied to the fractured lower limbs of patients, and then 100% CO2 was administered daily into a sealed space for 20 min over 4 weeks postoperatively. Safety was assessed based on vital signs, blood parameters, adverse events, and arterial and expired gas analyses. As the efficacy outcome, blood flow at the level of the fracture site and at a site 5 cm from the fracture in the affected limb was measured using a laser Doppler blood flow meter. RESULTS: Nineteen patients were subjected to complete analysis. No adverse events were observed. Arterial and expired gas analyses revealed no adverse systemic effects including hypercapnia. The mean ratio of blood flow 20 min after CO2 therapy compared with the pre-treatment level increased by approximately 2-fold in a time-dependent manner. CONCLUSIONS: The findings of the present study revealed that CO2 therapy is safe to apply to human patients and that it can enhance blood flow in the fractured limbs. TRIAL REGISTRATION: This study has been registered in the UMIN Clinical Trials Registry (Registration number: UMIN000013641, Date of registration: July 1, 2014).

  Nov. 2019, BMC musculoskeletal disorders, 20(1) (1), 563 - 563, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Angle Measurement of Two Rods in External Fixation Bracket Based on Image Processing

  Kaifeng Liu, Kouki Nagamune, Keisuke Oe

  Institute of Electrical and Electronics Engineers Inc., Nov. 2019, 2019 IEEE International Conference on Electrical, Control and Instrumentation Engineering, ICECIE 2019 - Proceedings, English

  International conference proceedings


• Insufficiency and deficiency of vitamin D in elderly patients with fragility fractures of the hip in the Japanese population.

  Niikura T, Oe K, Sakai Y, Iwakura T, Fukui T, Nishimoto H, Hayashi S, Matsumoto T, Matsushita T, Maruo A, Yagata Y, Kishimoto K, Sakurai A, Kuroda R

  Sep. 2019, Journal of orthopaedic surgery (Hong Kong), 27(3) (3), 2309499019877517, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Medial clavicle pseudarthrosis successfully treated with an inverted distal clavicle locking plate.

  Yu Sasaki, Sang Yang Lee, Takashi Iwakura, Tomoaki Fukui, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Teruya Kawamoto, Yutaka Mifune, Ryosuke Kuroda, Takahiro Niikura

  Introduction: Medial clavicle fractures are rare injuries. Symptomatic nonunion arises up to 8% of medial clavicle fractures when treated conservatively. Presentation of case: A 53-year-old man sustained a left medial clavicle fracture and was treated conservatively at another hospital. Nine months after his initial injury, he was referred to our institution. We diagnosed pseudarthrosis of the medial clavicle. We performed open reduction and internal fixation using an inverted distal clavicle locking plate. At the 1-year follow-up, radiographs showed bone union. Discussion: This is the first reported case of medial clavicle pseudarthrosis treated with an inverted distal clavicle anatomical locking plate. There are several advantages in using this plate. Conclusion: This method is a good treatment option.

  Aug. 2019, Annals of medicine and surgery (2012), 44, 1 - 4, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Topical cutaneous application of CO2 accelerates bone healing in a rat femoral defect model.

  Yu Kuroiwa, Tomoaki Fukui, Shunsuke Takahara, Sang Yang Lee, Keisuke Oe, Michio Arakura, Yohei Kumabe, Takahiro Oda, Tomoyuki Matsumoto, Takehiko Matsushita, Toshihiro Akisue, Yoshitada Sakai, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Bone defects may occur because of severe trauma, nonunion, infection, or tumor resection. However, treatments for bone defects are often difficult and have not been fully established yet. We previously designed an efficient system of topical cutaneous application of carbon dioxide (CO2) using a novel hydrogel, which facilitates CO2 absorption through the skin into the deep area within a limb. In this study, the effect of topical cutaneous application of CO2 on bone healing was investigated using a rat femoral defect model. METHODS: In this basic research study, an in vivo bone defect model, fixed with an external fixator, was created using a rat femur. The affected limb was shaved, and CO2 was applied for 20 min/day, 5 days/week. In the control animals, CO2 gas was replaced with air. Radiographic, histological, biomechanical, and genetic assessments were performed to evaluate bone healing. RESULTS: Radiographically, bone healing rate was significantly higher in the CO2 group than in the control group at 4 weeks (18.2% vs. 72.7%). The degree of bone healing scored using the histopathological Allen grading system was significantly higher in the CO2 group than in the control group at 2 weeks (1.389 ± 0.334 vs. 1.944 ± 0.375). The ultimate stress, extrinsic stiffness, and failure energy were significantly greater in the CO2 group than in the control group at 4 weeks (3.2 ± 0.8% vs. 38.1 ± 4.8%, 0.6 ± 0.3% vs. 41.5 ± 12.2%, 2.6 ± 0.8% vs. 24.7 ± 5.9%, respectively.). The volumetric bone mineral density of the callus in micro-computed tomography analysis was significantly higher in the CO2 group than in the control group at 4 weeks (180.9 ± 43.0 mg/cm3 vs. 247.9 ± 49.9 mg/cm3). Gene expression of vascular endothelial growth factor in the CO2 group was significantly greater than that in the control group at 3 weeks (0.617 ± 0.240 vs. 2.213 ± 0.387). CONCLUSIONS: Topical cutaneous application of CO2 accelerated bone healing in a rat femoral defect model. CO2 application can be a novel and useful therapy for accelerating bone healing in bone defects; further research on its efficacy in humans is warranted.

  May 2019, BMC musculoskeletal disorders, 20(1) (1), 237 - 237, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Escherichia coli-derived BMP-2-absorbed β-TCP granules induce bone regeneration in rabbit critical-sized femoral segmental defects.

  Yu Kuroiwa, Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Takashi Iwakura, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda

  PURPOSE: This study investigated whether Escherichia coli-derived bone morphogenetic protein (BMP)-2 (E-BMP-2) adsorbed onto β-tricalcium phosphate (β-TCP) granules can induce bone regeneration in critical-size femoral segmental defects in rabbits. METHODS: Bone defects 20 mm in size and stabilized with an external fixator were created in the femur of New Zealand white rabbits, which were divided into BMP-2 and control groups. E-BMP-2-loaded β-TCP granules were implanted into defects of the BMP-2 group, whereas defects in the controls were implanted with β-TCP granules alone. At 12 and 24 weeks after surgery, radiographs were obtained of the femurs and histological and biomechanical assessments of the defect area were performed. Bone regeneration was quantified using micro-computed tomography at 24 weeks. RESULTS: Radiographic and histologic analyses revealed bone regeneration in the BMP-2 group but not the control group; no fracturing of newly formed bone occurred when the external fixator was removed at 12 weeks. At 24 weeks, tissue mineral density, the ratio of bone volume to total volume, and volumetric bone mineral density of the callus were higher in the BMP-2 group than in control animals. In the former, ultimate stress, extrinsic stiffness, and failure energy measurements for the femurs were higher at 24 weeks than at 12 weeks. CONCLUSION: E-BMP-2-loaded β-TCP granules can effectively promote bone regeneration in long bone defects.

  May 2019, International orthopaedics, 43(5) (5), 1247 - 1253, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Periprosthetic Femoral Fracture with Characteristics of Atypical Femoral Fracture.

  Shuya Tanaka, Tomoaki Fukui, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Shinya Hayashi, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Although the definition of atypical femoral fracture (AFF) excludes periprosthetic femoral fracture (PFF), the number of reports about PFF with characteristics of AFF is increasing. We present the case of such a fracture in this report. An 87-year-old woman who underwent bipolar hip arthroplasty for a femoral neck fracture 38 months prior reported left thigh pain with no history of trauma. Radiographs showed a simple transverse fracture at the level of the stem distal end with features of AFF: periosteal thickening of the lateral cortex, a medial spike, and a noncomminuted fracture. She presented other features resembling AFF: history of bisphosphonate use, prodromal symptoms, no associated trauma, and lateral bowing of the contralateral femur. The fracture showed nonunion after the initial osteosynthesis, and a revision surgery of the arthroplasty and osteosynthesis was performed. Nine months after the surgery, bony union was achieved and she regained the ability to walk. It is supposed that the fracture was influenced by a stress force related to implants and lateral bowing concentrating on the fracture site as a mechanical factor in addition to bisphosphonates as a biological factor. It would be important to recognize that AFF could occur at the peri-implant location, and early detection and treatment are essential.

  2019, Case reports in orthopedics, 2019, 1275369 - 1275369, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Humeral Shaft Non-union in a Patient with Osteogenesis Imperfecta Treated with Mandible Locking Plate Fixation: A Case Report.

  Shohei Sano, Keisuke Oe, Tomoaki Fukui, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  Introduction: Osteogenesis imperfecta (OI) is a heritable disorder of connective tissue. Due to poor bone quality, patients with OI develop bone fracture and subsequent non-union at high rates. We report the rare case of humeral shaft non-union successfully treated by a locking plate used formandibular bone in a patient with OI. Case Report: A 26-year-old man with Type III OI and a history of corrective osteotomy with Kirschner wire fixation of his right humerus at the age of 8 years developed gradually increasing pain in his humerus. He sustained humeral shaft non-union due to a broken Kirschner wire used in the previous operation and was referred to our hospital. He underwent internal fixation using an elastic nail with an iliac bone graft. However, 2 years after the operation, bony union was not achieved due to elastic nail breakage, and he complained of pain and activity limitation. He underwent re-operation for the humeral non-union using a locking plate to achieve rigid fixation. Because his humeral shaft was extremely narrow with severe deformity, we used a locking plate for the mandibular bone, which was contoured to fit the medial side of the humeral shaft. Bony union was achieved, the pain was relieved, and the patient returned to his pre-injury activity with no symptoms.4years after the operation, a new fracture line was found in radiographs of the distal part of the non-union. Bony union was achieved by conservative treatment. At present, the function has recovered. Conclusion: Humeral non-union in this patient with OI was successfully treated by a mandible locking plate. Although the optimal fixation device for fractures or non-unions in patients with OI has not yet been established, this plate could be a good treatment option for narrow and severely deformed bone.

  2019, Journal of orthopaedic case reports, 9(3) (3), 19 - 21, English, International magazine

  [Refereed]


• Humeral Shaft Non-union in a Patient with Osteogenesis Imperfecta Treated with Mandible Locking Plate Fixation: A Case Report.

  Shohei Sano, Keisuke Oe, Tomoaki Fukui, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: Osteogenesis imperfecta (OI) is a heritable disorder of connective tissue. Due to poor bone quality, patients with OI develop bone fracture and subsequent non-union at high rates. We report the rare case of humeral shaft non-union successfully treated by a locking plate used formandibular bone in a patient with OI. CASE REPORT: A 26-year-old man with Type III OI and a history of corrective osteotomy with Kirschner wire fixation of his right humerus at the age of 8 years developed gradually increasing pain in his humerus. He sustained humeral shaft non-union due to a broken Kirschner wire used in the previous operation and was referred to our hospital. He underwent internal fixation using an elastic nail with an iliac bone graft. However, 2 years after the operation, bony union was not achieved due to elastic nail breakage, and he complained of pain and activity limitation. He underwent re-operation for the humeral non-union using a locking plate to achieve rigid fixation. Because his humeral shaft was extremely narrow with severe deformity, we used a locking plate for the mandibular bone, which was contoured to fit the medial side of the humeral shaft. Bony union was achieved, the pain was relieved, and the patient returned to his pre-injury activity with no symptoms.4years after the operation, a new fracture line was found in radiographs of the distal part of the non-union. Bony union was achieved by conservative treatment. At present, the function has recovered. CONCLUSION: Humeral non-union in this patient with OI was successfully treated by a mandible locking plate. Although the optimal fixation device for fractures or non-unions in patients with OI has not yet been established, this plate could be a good treatment option for narrow and severely deformed bone.

  2019, Journal of orthopaedic case reports, 9(3) (3), 19 - 21, English, International magazine

  Scientific journal


• Increase in carbon dioxide accelerates the performance of endurance exercise in rats.

  Takeshi Ueha, Keisuke Oe, Masahiko Miwa, Takumi Hasegawa, Akihiro Koh, Hanako Nishimoto, Sang Yang Lee, Takahiro Niikura, Masahiro Kurosaka, Ryosuke Kuroda, Yoshitada Sakai

  Springer Tokyo, Jul. 2018, The journal of physiological sciences : JPS, 68(4) (4), 463 - 470, English, Domestic magazine

  [Refereed]

  Scientific journal


• Automated femoral stem canal fill ratio evaluation for bipolar hip arthroplasty in 2D X-ray image

  Yosuke Uozumi, Kouki Nagamune, Keisuke Oe

  May 2018, Journal of Advanced Computational Intelligence and Intelligent Informatics, 22(3) (3), 333 - 340, English

  [Refereed]

  Scientific journal


• Altered expression of microRNA during fracture healing in diabetic rats

  S. Takahara, S. Y. Lee, T. Iwakura, K. Oe, T. Fukui, E. Okumachi, T. Waki, M. Arakura, Y. Sakai, K. Nishida, R. Kuroda, T. Niikura

  British Editorial Society of Bone and Joint Surgery, Feb. 2018, Bone and Joint Research, 7(2) (2), 139 - 147, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Minimally Invasive Treatment for Tibial Malrotation after Locked Intramedullary Nailing.

  Kyohei Takase, Sang Yang Lee, Takahiro Waki, Tomoaki Fukui, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda, Takahiro Niikura

  Rotational malreduction is a potential complication of intramedullary nailing for tibial shaft fractures. We experienced a symptomatic case of a 24° externally rotated malunion that we treated with minimally invasive corrective osteotomy. A 49-year-old man sustained a tibial shaft spiral fracture with a fibula fracture. He had been initially treated elsewhere with a reamed statically locked intramedullary nail. Bone union had been obtained, but he complained of asymmetry of his legs, difficulty walking and running, and the inability to ride a bicycle. We decided to perform corrective osteotomy in a minimally invasive fashion. After a 1 cm incision was made at the original fracture site, osteotomy for the affected tibia was performed with an osteotome after multiple efforts at drilling around the nail with the aim of retaining it. Fibula osteotomy was also performed at the same level. Two Kirschner wires that created an affected rotational angle between the fragments were inserted as a guide for correction. The distal locking screws were removed. Correct rotation was regained by matching the two wires in a straight line. Finally, the distal locking screws were inserted into new holes. The patient obtained bony union and has returned to his preinjury activities with no symptoms.

  2018, Case reports in orthopedics, 2018, 4190670 - 4190670, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Locking plate osteosynthesis for a femoral fracture and subsequent nonunion in a patient with osteopetrosis.

  Tomoya Matsuo, Sang Yang Lee, Takashi Iwakura, Tomoaki Fukui, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: Osteopetrosis is a skeletal disorder characterized by increased osteodensity and a remodeling defect. The fragility of dense sclerotic bones may lead to an increased incidence of fractures. Although internal fixation can be performed, technical challenges may be experienced because of the increased bone density. Complications such as delayed union, nonunion, or implant failure may occur postoperatively. PRESENTATION OF CASE: We describe a patient with autosomal-dominant osteopetrosis type 2 who suffered a shaft fracture below a plate of his right femur. We performed osteosynthesis with a single locking plate. Union was delayed, and plate breakage occurred along with nonunion of the fracture. The nonunion was addressed using double locking plates, which secured fixation and allowed complete fracture healing. DISCUSSION: There were three reasons of nonunion in our case. First, we left gaps between the fragments. Second, we used mainly cerclage wires, rather than screws, for plate fixation, which led to inadequate stability. Third, the patient was large (height 167 cm, weight 93.1 kg), so the single plate provided insufficient fixing force. We then used double locking plates and attained stronger internal fixation with complete fracture healing. CONCLUSION: Double plating with locking plates may be an effective treatment option for femoral fractures in patients with osteopetrosis.

  2018, International journal of surgery case reports, 51, 395 - 399, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Rescue of ankylosing hip following open reduction and internal fixation of acetabular fracture by surgical resection of heterotopic ossification: A case report.

  Kazumichi Kitayama, Yohei Kawakami, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: Heterotopic ossification is a major complication after surgical treatment of acetabular fractures. Heterotopic ossification generally involves the large joints, often limits the range of motion, and may cause ankylosis. PRESENTATION OF CASE: This case report describes a 59-year-old man with severe heterotopic ossification who developed an acetabular fracture and resultant hip ankylosis, which was rescued by surgical resection of the heterotopic ossification. He had accompanying head injury and multiple other fractures, which were treated conservatively. Open reduction with internal fixation of the acetabular fracture was performed through the ilioinguinal and Kocher-Langenbeck combined approach. The patient unexpectedly returned to our hospital 7.5 months after the fracture surgery. We found that his left hip joint was completely ankylosed by severe heterotopic ossification. We performed surgical resection of the heterotopic ossification through a direct lateral approach 9.5 months after the initial surgery. At the final follow-up, 5.5 years after the heterotopic ossification resection surgery, the hip function including the range of motion was satisfactory. Radiographs showed no signs of recurrence, and he could walk with no support. DISCUSSION: The only effective treatment for established HO is surgical excision. Whether delayed or early surgical resection of heterotopic ossification is more effective remains controversial. CONCLUSION: We considered that waiting for a long time before surgical resection of the heterotopic ossification would lead to more disability, and early resection of the heterotopic ossification was not a contraindication despite the fact that the uptake on the bone scan was still intense.

  2018, International journal of surgery case reports, 53, 107 - 111, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Proposal of new classification of femoral trochanteric fracture by three-dimensional computed tomography and relationship to usual plain X-ray classification.

  Etsuo Shoda, Shimpei Kitada, Yu Sasaki, Hitoshi Hirase, Takahiro Niikura, Sang Yang Lee, Atsushi Sakurai, Keisuke Oe, Takeharu Sasaki

  SAGE Publications Ltd, Jan. 2017, Journal of orthopaedic surgery (Hong Kong), 25(1) (1), 2309499017692700 - 2309499017692700, English, International magazine

  [Refereed]

  Scientific journal


• Profiling microRNA expression during fracture healing.

  Takahiro Waki, Sang Yang Lee, Takahiro Niikura, Takashi Iwakura, Yoshihiro Dogaki, Etsuko Okumachi, Keisuke Oe, Ryosuke Kuroda, Masahiro Kurosaka

  Feb. 2016, BMC musculoskeletal disorders, 17, 83 - 83, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Development of Evaluation System for Pelvic Belt by Using Force Sensor

  Kouki Nagamune, Keisuke Oe

  2016, 2016 JOINT 8TH INTERNATIONAL CONFERENCE ON SOFT COMPUTING AND INTELLIGENT SYSTEMS (SCIS) AND 17TH INTERNATIONAL SYMPOSIUM ON ADVANCED INTELLIGENT SYSTEMS (ISIS), 822 - 826, English

  [Refereed]

  International conference proceedings


• Clinical and radiological results of locking plate fixation for periprosthetic femoral fractures around hip arthroplasties: a retrospective multi-center study.

  Takahiro Niikura, Atsushi Sakurai, Keisuke Oe, Nao Shibanuma, Masaya Tsunoda, Akihiro Maruo, Etsuo Shoda, Sang Yang Lee, Yoshitada Sakai, Masahiro Kurosaka

  Nov. 2014, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 19(6) (6), 984 - 90, English, Domestic magazine

  [Refereed]

  Scientific journal


• Missed massive morel-lavallee lesion.

  Shunsuke Takahara, Keisuke Oe, Hironori Fujita, Atsushi Sakurai, Takashi Iwakura, Sang Yang Lee, Takahiro Niikura, Ryosuke Kuroda, Masahiro Kurosaka

  A Morel-Lavallee lesion (MLL) involves posttraumatic fluid collection around the greater trochanter. Many cases of MLL are missed at the initial evaluation, and the treatment of MLL is not well established. We present two cases in which MLL was missed at the initial evaluation. Case 1. A 65-year-old man was run over by a parade float. There was subcutaneous hematoma around the left greater trochanter, and no fracture was found. We diagnosed this injury as MLL on the 7th day after the trauma. Although we performed percutaneous drainage, the injured area was infected. Case 2. A 57-year-old man was hit by a train in a factory. There was an iliac wing fracture, but an MLL was not initially recognized. On the 6th day after the trauma, when performing open reduction and internal fixation for the iliac fracture, we recognized the lesion and performed percutaneous drainage simultaneously. This lesion also became infected. In these two cases, the wounds finally healed after a long duration of treatment. We suggest that it is important to keep this injury in mind and debride the lesion early and completely in the treatment course.

  2014, Case reports in orthopedics, 2014, 920317 - 920317, English, International magazine

  [Refereed]

  Scientific journal


• Analysis of circulating mesenchymal progenitor cells in arterial and venous blood after fracture.

  Takashi Iwakura, Sang Yang Lee, Masahiko Miwa, Yoshitada Sakai, Takahiro Niikura, Keisuke Oe, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2013, Journal of tissue engineering and regenerative medicine, 7(6) (6), 501 - 4, English, International magazine

  [Refereed]

  Scientific journal


• Low-intensity pulsed ultrasound enhances BMP-7-induced osteogenic differentiation of human fracture hematoma-derived progenitor cells in vitro.

  Sang Yang Lee, Akihiro Koh, Takahiro Niikura, Keisuke Oe, Takaaki Koga, Yoshihiro Dogaki, Masahiro Kurosaka

  Jan. 2013, Journal of orthopaedic trauma, 27(1) (1), 29 - 33, English, International magazine

  [Refereed]

  Scientific journal


• Novel Surgical Treatment for Refractory Heel Ulcers in Werner's Syndrome.

  Keisuke Oe, Masahiko Miwa, Yoshitada Sakai, Masahiro Kurosaka

  Patients with Werner's syndrome frequently develop chronic leg ulcers that heal poorly. We present a patient who suffered from this rare syndrome and developed typical heel ulcers. Treatment of the ulcer is challenging, as flap options are limited over the lower third of the leg and skin grafting is not easy as there is a lack of healthy granulations. We successfully treated the ulcer with osteomyelitis by drilling the bone and applying an ultrathin split thickness skin graft with the thigh skin as the donor site.

  2013, Case reports in orthopedics, 2013, 287025 - 287025, English, International magazine

  [Refereed]

  Scientific journal


• Incidence of venous thromboembolism in fractures around and below the knee with physical prophylaxis.

  Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Akihiro Koh, Takaaki Koga, Yoshihiro Dogaki, Etsuko Okumachi, Yoshitada Sakai, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka

  Oct. 2012, Orthopedics, 35(10) (10), e1476-82 - E1482, English, International magazine

  [Refereed]

  Scientific journal


• Venous thromboembolism in Japanese patients with fractures of the pelvis and/or lower extremities using physical prophylaxis alone.

  Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Akihiro Koh, Takaaki Koga, Yoshihiro Dogaki, Etsuko Okumachi, Masahiro Kurosaka

  Aug. 2012, Journal of orthopaedic surgery (Hong Kong), 20(2) (2), 196 - 200, English, International magazine

  [Refereed]

  Scientific journal


• Technique to prepare the bed for autologous bone grafting in nonunion surgery.

  Takahiro Niikura, Masahiko Miwa, Sang Yang Lee, Keisuke Oe, Takashi Iwakura, Yoshitada Sakai, Akihiro Koh, Takaaki Koga, Yoshihiro Dogaki, Etsuko Okumachi, Masahiro Kurosaka

  Jun. 2012, Orthopedics, 35(6) (6), 491 - 5, English, International magazine

  [Refereed]

  Scientific journal


• Incidence of venous thromboembolism in pelvic and acetabular fractures in the Japanese population.

  Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Akihiro Koh, Takaaki Koga, Yoshihiro Dogaki, Etsuko Okumachi, Masahiro Kurosaka

  May 2012, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 17(3) (3), 233 - 8, English, Domestic magazine

  [Refereed]

  Scientific journal


• Mandibular hematoma cells as a potential reservoir for osteoprogenitor cells in fractures.

  Takumi Hasegawa, Masahiko Miwa, Yoshitada Sakai, Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Takashi Iwakura, Masahiro Kurosaka, Takahide Komori

  Mar. 2012, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 70(3) (3), 599 - 607, English, International magazine

  [Refereed]

  Scientific journal


• Operative Management of Periarticular Medial Clavicle Fractures-Report of 10 Cases.

  Keisuke Oe, Leander Gaul, Christian Hierholzer, Alexander Woltmann, Masahiko Miwa, Masahiro Kurosaka, Volker Buehren

  Feb. 2012, The journal of trauma and acute care surgery, 72(2) (2), E1-E7 - E7, English, International magazine

  [Refereed]

  Scientific journal


• Lateral Supra-acetabular External Fixation for Unstable Pelvic Ring Fracture: A Biomechanical Assessments

  M. M. S. Hanafi, Shogo Kawaguchi, Kouki Nagamune, Keisuke Oe, Sang Yang Lee, Takahiro Niikura, Ryosuke Kuroda, Masahiro Kurosaka

  2012, 2012 IEEE INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS (FUZZ-IEEE), 1 - 6, English

  [Refereed]

  International conference proceedings


• Differential gene expression and immunolocalization of insulin-like growth factors and insulin-like growth factor binding proteins between experimental nonunions and standard healing fractures.

  Akihiro Koh, Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Takaaki Koga, Yoshihiro Dogaki, Masahiro Kurosaka

  Dec. 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 29(12) (12), 1820 - 6, English, International magazine

  [Refereed]

  Scientific journal


• Negative pressure wound therapy for the treatment of infected wounds with exposed knee joint after patellar fracture.

  Sang Yang Lee, Takahiro Niikura, Masahiko Miwa, Yoshitada Sakai, Keisuke Oe, Takahiro Fukazawa, Yohei Kawakami, Masahiro Kurosaka

  Jun. 2011, Orthopedics, 34(6) (6), 211 - 211, English, International magazine

  [Refereed]

  Scientific journal


• The effect of transcutaneous application of carbon dioxide (CO₂) on skeletal muscle.

  Keisuke Oe, Takeshi Ueha, Yoshitada Sakai, Takahiro Niikura, Sang Yang Lee, Akihiro Koh, Takumi Hasegawa, Masaya Tanaka, Masahiko Miwa, Masahiro Kurosaka

  Apr. 2011, Biochemical and biophysical research communications, 407(1) (1), 148 - 52, English, International magazine

  [Refereed]

  Scientific journal


• Local transplantation of G-CSF-mobilized CD34(+) cells in a patient with tibial nonunion: a case report.

  Ryosuke Kuroda, Tomoyuki Matsumoto, Masahiko Miwa, Atsuhiko Kawamoto, Yutaka Mifune, Tomoaki Fukui, Yohei Kawakami, Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Taro Shoji, Tomoya Kuroda, Miki Horii, Ayumi Yokoyama, Takayuki Ono, Yasushi Koibuchi, Shin Kawamata, Masanori Fukushima, Masahiro Kurosaka, Takayuki Asahara

  2011, Cell transplantation, 20(9) (9), 1491 - 6, English, International magazine

  [Refereed]

  Scientific journal


• A novel system for transcutaneous application of carbon dioxide causing an "artificial Bohr effect" in the human body.

  Yoshitada Sakai, Masahiko Miwa, Keisuke Oe, Takeshi Ueha, Akihiro Koh, Takahiro Niikura, Takashi Iwakura, Sang Yang Lee, Masaya Tanaka, Masahiro Kurosaka

  2011, PloS one, 6(9) (9), e24137, English, International magazine

  [Refereed]

  Scientific journal


• [Nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD)].

  Keisuke Oe, Tsunehiro Ochi, Yoshizumi Hayase, Toshiji Saibara

  Jan. 2011, Nihon rinsho. Japanese journal of clinical medicine, 69 Suppl 1, 406 - 9, Japanese, Domestic magazine

  Scientific journal


• Efficient Cell-seeding into Scaffolds Improves Bone Formation

  T. Hasegawa, M. Miwa, Y. Sakai, T. Niikura, S. Y. Lee, K. Oe, T. Iwakura, M. Kurosaka, T. Komori

  Aug. 2010, JOURNAL OF DENTAL RESEARCH, 89(8) (8), 854 - 859, English

  [Refereed]

  Scientific journal


• Nondestructive evaluation of cell numbers in bone marrow stromal cell/beta-tricalcium phosphate composites using ultrasound.

  Keisuke Oe, Masahiko Miwa, Kouki Nagamune, Yoshitada Sakai, Sang Yang Lee, Takahiro Niikura, Takashi Iwakura, Takumi Hasegawa, Nao Shibanuma, Yutaka Hata, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2010, Tissue engineering. Part C, Methods, 16(3) (3), 347 - 53, English, International magazine

  [Refereed]

  Scientific journal


• Soft Computing Approaches to Identify Cellular Quantity of Artificial Culture Bone

  Naomi Yagi, Yoshitetsu Oshiro, Osamu Ishikawa, Keisuke Oe, Yutaka Hata

  2010, 2010 IEEE INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS (FUZZ-IEEE 2010), 1 - 6, English

  [Refereed]

  International conference proceedings


• Bilateral double-layered lateral meniscus: a report of two cases.

  Koji Takayama, Ryosuke Kuroda, Tomoyuki Matsumoto, Daisuke Araki, Norifumi Fujita, Katsumasa Tei, Yutaka Mifune, Keisuke Oe, Takehiko Matsushita, Seiji Kubo, Keisuke Kinoshita, Akio Matsumoto, Masahiro Kurosaka

  Nov. 2009, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 17(11) (11), 1336 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Ankle arthrodesis using antegrade intramedullary nail for salvage of nonreconstructable tibial pilon fractures.

  Takahiro Niikura, Masahiko Miwa, Yoshitada Sakai, Sang Yang Lee, Keisuke Oe, Takashi Iwakura, Akihiro Koh, Takaaki Koga, Masahiro Kurosaka

  Aug. 2009, Orthopedics, 32(8) (8), 611, English, International magazine

  [Refereed]

  Scientific journal


• Is extensive cervical laminoplasty an effective treatment for spinal cord sarcoidosis combined with cervical spondylosis?

  Keisuke Oe, Minoru Doita, Hiroshi Miyamoto, Fumio Kanda, Masahiro Kurosaka, Masatoshi Sumi

  Apr. 2009, European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 18(4) (4), 570 - 6, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Human hypertrophic nonunion tissue contains mesenchymal progenitor cells with multilineage capacity in vitro.

  Takashi Iwakura, Masahiko Miwa, Yoshitada Sakai, Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Takumi Hasegawa, Ryosuke Kuroda, Hiroyuki Fujioka, Minoru Doita, Masahiro Kurosaka

  Feb. 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 27(2) (2), 208 - 15, English, International magazine

  [Refereed]

  Scientific journal


• Isolation and characterization of connective tissue progenitor cells derived from human fracture-induced hemarthrosis in vitro.

  Sang Yang Lee, Masahiko Miwa, Yoshitada Sakai, Ryosuke Kuroda, Keisuke Oe, Takahiro Niikura, Tomoyuki Matsumoto, Hiroyuki Fujioka, Minoru Doita, Masahiro Kurosaka

  Feb. 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 26(2) (2), 190 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Fuzzy Ultrasonic System for Identifying Cellular Quantity of Artificial Culture Bone

  Yutaka Hata, Satoshi Yamaguchi, Syoji Kobashi, Keisuke Oe

  2008, 2008 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN AND CYBERNETICS (SMC), VOLS 1-6, 3061 - +, English

  [Refereed]

  International conference proceedings


• Fuzzy logic approach to identification of cellular quantity by ultrasonic system

  Satoshi Yamaguchi, Kouki Nagamune, Keisuke Oe, Syoji Kobashi, Katsuya Kondo, Yutaka Hata

  2007, GRC: 2007 IEEE INTERNATIONAL CONFERENCE ON GRANULAR COMPUTING, PROCEEDINGS, 636 - +, English

  [Refereed]

  International conference proceedings


• A fuzzy estimation system for cellular quantity of artificial culture bone

  Satoshi Yamaguchi, Kouki Nagamune, Keisuke Oe, Syoji Kobashi, Katsuya Kondo, Yutaka Hata

  2007, 2007 IEEE/ICME INTERNATIONAL CONFERENCE ON COMPLEX MEDICAL ENGINEERING, VOLS 1-4, 426 - 429, English

  [Refereed]

  International conference proceedings


• An in vitro study demonstrating that haematomas found at the site of human fractures contain progenitor cells with multilineage capacity

  K. Oe, M. Miwa, Y. Sakai, S. Y. Lee, R. Kuroda, M. Kurosaka

  Jan. 2007, JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 89B(1) (1), 133 - 138, English

  [Refereed]

  Scientific journal

• 体外ロッキングプレート固定が奏功した一例

  傳直樹, 新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2025, 中部日本整形外科災害外科学会雑誌, 68


• 透析患者の異所性石灰化に伴う病的骨折に対して腫瘍用インプラントを用いて治療を行った一例

  水谷太郎, 原仁美, 澤田良子, 大江啓介, 秋末敏宏, 黒田良祐

  2025, 中部日本整形外科災害外科学会雑誌, 68


• 骨接合後感染に対する持続局所抗菌薬潅流(CLAP)の有効例と成績不良例の解析

  高原俊介, 山下伸之輔, 山川泰明, 大江啓介, 新倉隆宏, 圓尾明弘

  2025, 中部日本整形外科災害外科学会雑誌, 68


• CLAPにおけるゲンタマイシン濃度による細胞傷害と腎機能障害のリスク因子ついて

  大江啓介, 福井友章, 隈部洋平, 山本裕也, 新倉隆宏, 黒田良祐

  2025, 中部日本整形外科災害外科学会雑誌, 68


• 大きな回旋変形を伴う小児大腿骨骨幹部骨折後偽関節の1例

  吉田圭助, 隈部洋平, 大江啓介, 福井友章

  2025, 中部日本整形外科災害外科学会雑誌, 68


• 上肢 2.肩関節脱臼

  大江啓介

  2025, レジデントノート, 27(8) (8)


• NPWTもしくはCLAPを用いた脊椎インプラント周囲感染の治療経験

  青木大地, 高須啓之, 大江啓介, 寺師浩人, 野村正, 榊原俊介

  2025, 日本形成外科学会総会・学術集会プログラム・抄録集, 68th


• 人工股関節置換術後に生じた難治性潰瘍に対する皮弁による治療

  古賀郁也, 上田美怜, 大江啓介, 林申也, 榊原俊介, 野村正, 寺師浩人

  2025, 日本形成外科学会総会・学術集会プログラム・抄録集, 68th


• 大腿骨近位部骨折の周術期合併症・死亡率は,どの程度の早期手術で減少するか

  伊藤克拓, 岩倉崇, 安部真人, 堂垣佳宏, 大江啓介, 角田雅也

  2025, 日本整形外科学会雑誌(CD-ROM), 99(3) (3)


• 高齢大腿骨近位部骨折の生命・機能予後不良因子の検討

  岩倉崇, 安部真人, 堂垣佳宏, 西本浩司, 大江啓介, 角田雅也

  2025, 日本整形外科学会雑誌(CD-ROM), 99(3) (3)


• 同側の変形性股関節症を合併した非定型大腿骨骨折の治療経過についての検討

  福井友章, 大江啓介, 隈部洋平, 松宮豊, 新倉隆宏, 黒田良祐

  2025, 日本整形外科学会雑誌(CD-ROM), 99(3) (3)


• 骨折関連感染症治療の治療成績に影響する要因の検討-多施設研究-

  高原俊介, 善家雄吉, 姫野大輔, 山下伸之輔, 松本匡洋, 山川泰明, 森井北斗, 大江啓介, 新倉隆宏, 圓尾明弘

  2025, 日本整形外科学会雑誌(CD-ROM), 99(3) (3)


• 当院における人工関節周囲感染に対する持続局所抗菌薬灌流療法の治療成績の検討

  大江啓介, 福井友章, 隈部洋平, 松宮豊, 松本知之, 林申也, 黒田良祐

  2025, 日本整形外科学会雑誌(CD-ROM), 99(3) (3)


• 大腿骨近位部骨折における微量元素-Cuの可能性-

  脇貴洋, 石丸直人, 大江啓介, 矢野智則, 伊藤研二郎, 松島真司, 水木真平, 官澤洋平, 黒田良祐

  2025, 日本整形外科学会雑誌(CD-ROM), 99(3) (3)


• 高齢大腿骨近位部骨折における栄養指標と1年時の生命・機能予後との関連

  岩倉崇, 安部真人, 堂垣佳宏, 西本浩司, 大江啓介, 角田雅也

  2025, 日本整形外科学会雑誌(CD-ROM), 99(3) (3)


• 有限要素法を用いたRIA(reamer irrigator aspirator)が大腿骨力学強度に与える影響の解析

  隈部洋平, 西田亮太, 松宮豊, 福井友章, 大江啓介, 黒田良祐

  2025, 日本整形外科学会雑誌(CD-ROM), 99(3) (3)


• 難治骨折診療から学んだ骨折治療の極意

  大江啓介

  2025, 日本理学療法学会プログラム・抄録集, 73rd


• 当院における人工関節周囲感染に対する持続局所抗菌薬灌流療法の治療成績

  大江啓介, 福井友章, 隈部洋平, 松宮豊, 松本知之, 林申也, 美舩泰, 黒田雄一, 壺坂正徳, 亀長智幸, 黒田良祐

  2025, 日本人工関節学会プログラム・抄録集, 55th (CD-ROM)


• 脛骨プラトー骨折治療戦略 脛骨プラトー骨折に関連する合併症とその対応

  大江啓介

  2025, Monthly Book Orthopaedics, 38(6) (6)


• 大腿骨近位部骨折のリハビリテーション診療 大腿骨近位部骨折の診断と分類up-to-date

  大江啓介

  2025, Journal of Clinical Rehabilitation, 34(7) (7)


• 【外傷・治療・看護の必須観察ポイント「超」まるごと骨折 これ一冊】(第3章)上肢の骨折 上腕骨骨幹部骨折

  大江 啓介

  (株)メディカ出版, Jun. 2024, 整形外科看護, (2024夏季増刊) (2024夏季増刊), 76 - 81, Japanese


• 上肢の骨折 C 上腕骨骨幹部骨折

  大江啓介

  2024, 整形外科看護


• Regeneration therapy of bone and vessel by transplantation of autologous CD34-positive cells

  大江啓介, 新倉隆宏, 福井友章, 隈部洋平, 松本知之, 黒田良祐

  2024, 整形・災害外科, 67(5) (5)


• 持続局所抗菌薬潅流(CLAP)が骨折関連感染症治療における医療費に与える影響

  吉田健亮, 高原俊介, 川崎一旭, 善家雄吉, 善家雄吉, 姫野大輔, 姫野大輔, 山下伸之輔, 松本匡洋, 山川泰明, 森井北斗, 大江啓介, 新倉隆宏, 圓尾明弘, 圓尾明弘

  2024, 整形外科と災害外科, 73(Suppl.1) (Suppl.1)


• 骨折関連感染症に対する持続局所抗菌薬潅流(CLAP)の有効性-多施設研究-

  高原俊介, 高原俊介, 川崎一旭, 吉田健亮, 善家雄吉, 善家雄吉, 姫野大輔, 姫野大輔, 山下伸之輔, 松本匡洋, 山川泰明, 森井北斗, 大江啓介, 新倉隆宏, 圓尾明弘, 圓尾明弘

  2024, 整形外科と災害外科, 73(Suppl.1) (Suppl.1)


• 細菌性腹膜炎への腹腔内222nmUVC照射による腹水中細菌制御効果と安全性の検証

  杉山洸裕, 立田協太, 小嶋忠浩, 赤井俊也, 鈴木克徳, 鳥居翔, 阪田麻裕, 森田剛文, 菊池寛利, 平松良浩, 隈部洋平, 大江啓介, 福井友章, 黒田良祐, 倉地清隆, 竹内裕也

  2024, 日本外科学会定期学術集会(Web), 124th


• 非定型大腿骨骨折において骨転移に対する骨修飾薬使用歴の有無が治療経過に与える影響

  福井友章, 大江啓介, 隈部洋平, 新倉隆宏, 黒田良祐

  2024, 日本整形外科学会雑誌, 98(2) (2)


• 大腿骨近位部骨折の早期手術を妨げる要因は何か

  石村颯貴, 岩倉崇, 伊藤克拓, 安部真人, 大江啓介, 堂垣佳宏, 西本浩司, 角田雅也

  2024, 日本整形外科学会雑誌, 98(2) (2)


• CLAPにおけるゲンタマイシンの薬物動態に関する検討

  松宮豊, 大江啓介, 福井友章, 隈部洋平, 黒田良祐

  2024, 日本整形外科学会雑誌, 98(2) (2)


• 骨折関連感染症に対する持続局所抗菌薬潅流の有効性-多施設研究-

  高原俊介, 善家雄吉, 姫野大輔, 姫野大輔, 松本匡洋, 森井北斗, 大江啓介, 新倉隆宏, 圓尾明弘

  2024, 日本整形外科学会雑誌, 98(2) (2)


• 骨折関連感染症に対する有効性と安全性を意識した持続局所抗菌薬潅流(CLAP)の実際

  高原俊介, 圓尾明弘, 善家雄吉, 姫野大輔, 姫野大輔, 新倉隆宏, 大江啓介, 松本匡洋, 森井北斗, 青木謙二, 中川夏子, 高山博行

  2024, 日本整形外科学会雑誌, 98(3) (3)


• Outcomes of secondary fracture prevention after hip fracture

  岩倉崇, 安部真人, 堂垣佳宏, 西本浩司, 大江啓介, 角田雅也

  2024, 中部日本整形外科災害外科学会雑誌, 67(4) (4)


• 多施設医師主導治験「自家末梢血CD34陽性細胞移植による骨・血管再生」

  黒田良祐, 松本知之, 大江啓介, 福井友章, 美舩泰, 新倉隆宏

  2024, 日本整形外科学会雑誌, 98(3) (3)


• 当院の二次性骨折予防継続管理の取り組みとその成果

  岩倉崇, 岩倉崇, 安部真人, 堂垣佳宏, 西本浩司, 大江啓介, 角田雅也

  2024, 中部日本整形外科災害外科学会雑誌, 67


• 人工膝関節全置換術後の細菌感染治療経過中に真菌感染をきたし,一期的に再置換術を施行した一例

  菅野龍彦, 松本知之, 中野直樹, 壺坂正徳, 大江啓介, 黒田良祐

  2024, 中部日本整形外科災害外科学会雑誌, 67


• 人工股関節ステム周囲骨折後偽関節の治療経験

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2024, 中部日本整形外科災害外科学会雑誌, 67


• 膝関節が露出した膝蓋骨骨折術後感染をCLAPと腓腹筋弁によりサルベージした一例

  藤原悠, 大江啓介, 福井友章, 隈部洋平, 黒田良祐

  2024, 中部日本整形外科災害外科学会雑誌, 67


• Mycobacterium abscessus complex感染による骨髄炎・化膿性関節炎をCLAP(continuous local antibiotics perfusion)で治療した一例

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2024, 日本骨・関節感染症学会プログラム・抄録集, 47th


• 骨折治療後長期に排膿を繰り返す慢性骨髄炎に対する持続局所抗菌薬灌流療法の短期治療成績

  大江啓介, 福井友章, 隈部洋平, 松宮豊, 黒田良祐

  2024, 日本骨・関節感染症学会プログラム・抄録集, 47th


• Investigation of a new bone regeneration therapy using the Masquelet technique for rabbit femoral bone defects

  山本裕也, 福井友章, 大江啓介, 隈部洋平, 澤内健一, 吉川遼, 高瀬恭平, 西田亮太, 近藤飛馬, 新倉隆宏, 黒田良祐

  2024, 骨折(Web), 46(Supplement (CD-ROM)) (Supplement (CD-ROM))


• 骨折関連感染症治療に対する持続局所抗菌薬潅流(CLAP)の有効性-多施設研究-

  高原俊介, 善家雄吉, 姫野大輔, 山下伸之輔, 松本匡洋, 山川泰明, 森井北斗, 大江啓介, 新倉隆宏, 圓尾明弘

  2024, 日本骨・関節感染症学会プログラム・抄録集, 47th


• Results of treatment for nonunion of periprosthetic fracture

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2024, 骨折(Web), 46(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Can RIA products be an alternative to autologous iliac cancellous bone grafts?

  大江啓介, 福井友章, 隈部洋平, 松宮豊, 新倉隆宏, 黒田良祐

  2024, 骨折(Web), 46(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Results of CLON (chipping and lengthening over nailing) technique to treat shortening, deformity, and nonunion of femur

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2024, 骨折(Web), 46(Supplement (CD-ROM)) (Supplement (CD-ROM))


• 骨折関連感染症治療における持続局所抗菌薬潅流(CLAP)のゲンタマイシンの投与濃度に関する検討-多施設研究-

  大江啓介, 福井友章, 隈部洋平, 松宮豊, 山本裕也, 高原俊介, 善家雄吉, 姫野大輔, 山下伸之輔, 松本匡洋, 山川泰明, 森井北斗, 新倉隆宏, 圓尾明弘

  2024, 日本骨・関節感染症学会プログラム・抄録集, 47th


• 骨折関連感染症治療に対する持続局所抗菌薬潅流(CLAP)の安全性の評価-多施設研究-

  北澤大也, 善家雄吉, 姫野大輔, 山下伸之輔, 松本匡洋, 山川泰明, 森井北斗, 大江啓介, 新倉隆宏, 高原俊介, 圓尾明弘

  2024, 日本骨・関節感染症学会プログラム・抄録集, 47th


• Orthogeriatric co-management in collaboration with general medicine can allow early and safe surgery for hip fracture with severe AS

  脇貴洋, 江川強志, 安見武哲, 新倉路生, 矢野智則, 伊藤研二郎, 大江啓介, 松島真司

  2024, 骨折(Web), 46(Supplement (CD-ROM)) (Supplement (CD-ROM))


• 人工足関節置換術後感染に対し持続局所抗菌薬灌流療法を併用した足関節固定術が奏功した1例

  松宮豊, 大江啓介, 福井友章, 隈部洋平, 黒田良祐

  2024, 日本骨・関節感染症学会プログラム・抄録集, 47th


• Results of phase I/II clinical trial of BMP-2/artificial bone composite for patients of long bone fracture nonunions. The second report

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2024, 骨折(Web), 46(Supplement (CD-ROM)) (Supplement (CD-ROM))


• CD34-positive cell transplantation and bone morphogenetic protein to treat atrophic nonunion

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2024, 骨折(Web), 46(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Results of surgical treatment for nonunion of subtrochanteric atypical femoral fracture

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2024, 骨折(Web), 46(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Three cases of chipping corrective osteotomies with intramedullary nail for reconstruction of malunion

  西田亮太, 大江啓介, 福井友章, 隈部洋平, 近藤飛馬, 山本裕也, 高瀬恭平, 新倉隆宏, 黒田良祐

  2024, 骨折(Web), 46(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Local antibiotics perfusion (CLAP) on treatment efficacy in fracture-related infections: A multi-center study

  高原俊介, 高原俊介, 善家雄吉, 善家雄吉, 姫野大輔, 姫野大輔, 山下伸之輔, 山下伸之輔, 松本匡洋, 山川泰明, 森井北斗, 大江啓介, 新倉隆宏, 圓尾明弘, 圓尾明弘

  2024, 骨折(Web), 46(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Results of surgery without local exposure and autologous bone graft to treat humeral nonunion

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2024, 骨折(Web), 46(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Treatment of atypical femoral fractures combined with ipsilateral hip osteoarthritis

  福井友章, 大江啓介, 隈部洋平, 松宮豊, 新倉隆宏, 黒田良祐

  2024, 骨折(Web), 46(Supplement (CD-ROM)) (Supplement (CD-ROM))


• 2 cases of internal infection using mesh plate for proximal phalanx pseudarthrosis of the great toe

  近藤飛馬, 福井友章, 大江啓介, 西田亮太, 山本裕也, 高瀬恭平, 隈部洋平, 新倉隆弘, 黒田良祐

  2024, 骨折(Web), 46(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Nonunion with rotational deformity after pediatric femoral shaft fracture

  隈部洋平, 大江啓介, 福井友章, 松宮豊, 黒田良祐

  2024, 骨折(Web), 46(Supplement (CD-ROM)) (Supplement (CD-ROM))


• 骨形成不全症患者へのビスホスホネート高用量投与後に生じた両側非定型大腿骨骨折の1例

  新倉隆宏, 島稔樹, 大江啓介, 福井友章, 黒田良祐

  2024, 日本骨粗鬆症学会雑誌, 10(Suppl.1 (CD-ROM)) (Suppl.1 (CD-ROM))


• 間欠的な細胞外低pH環境がヒト臍帯静脈内皮細胞活性に及ぼす影響

  西田亮太, 福井友章, 大江啓介, 隈部洋平, 近藤飛馬, 山本裕也, 高瀬恭平, 吉川遼, 新倉隆宏, 黒田良祐

  2024, 日本整形外科学会雑誌(CD-ROM), 98(8) (8)


• 廃用性骨粗鬆症ラットの骨折モデルにおける炭酸ガス経皮吸収療法の効果の検討

  近藤飛馬, 福井友章, 大江啓介, 隈部洋平, 西田亮太, 山本裕也, 高瀬恭平, 黒田良祐

  2024, 日本整形外科学会雑誌(CD-ROM), 98(8) (8)


• 新たなウサギMasquelet法モデルを用いた自家骨移植とBMP-2投与の骨再生効果の比較

  山本裕也, 福井友章, 大江啓介, 隈部洋平, 澤内健一, 吉川遼, 高瀬恭平, 西田亮太, 近藤飛馬, 新倉隆宏, 黒田良祐

  2024, 日本整形外科学会雑誌(CD-ROM), 98(8) (8)


• 骨折治癒における炭酸ガス経皮吸収療法の至適時間の検討

  近藤飛馬, 高瀬恭平, 福井友章, 大江啓介, 隈部洋平, 西田亮太, 山本裕也, 吉川遼, 新倉隆宏, 黒田良祐

  2024, 日本整形外科学会雑誌(CD-ROM), 98(8) (8)


• 後肢懸垂ラットによる廃用性骨萎縮・筋萎縮に対する炭酸ガス経皮吸収の予防効果

  西田亮太, 福井友章, 大江啓介, 隈部洋平, 近藤飛馬, 山本裕也, 高瀬恭平, 吉川遼, 新倉隆宏, 黒田良祐, 黒田良祐

  2024, 日本整形外科学会雑誌(CD-ROM), 98(8) (8)


• 当院における人工関節感染に対する持続局所抗菌薬灌流療法の治療成績

  大江啓介, 福井友章, 隈部洋平, 松本知之, 林申也, 黒田良祐

  2024, 中部日本整形外科災害外科学会雑誌, 67


• RIA(Reamer Irrigator Aspirator)が大腿骨の力学強度に与える影響に関する有限要素解析

  隈部洋平, 松宮豊, 福井友章, 大江啓介, 黒田良祐

  2024, 中部日本整形外科災害外科学会雑誌, 67


• 四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果(続報)

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2024, 中部日本整形外科災害外科学会雑誌, 67


• 人工足関節置換術後の破綻に対し金属スペーサーを用いて関節固定を行った2例

  松宮豊, 大江啓介, 福井友章, 隈部洋平, 黒田良祐

  2024, 中部日本整形外科災害外科学会雑誌, 67


• 外傷後変形癒合に対してchipping corrective osteotomyを施行した3例

  西田亮太, 大江啓介, 福井友章, 隈部洋平, 新倉隆宏, 黒田良祐

  2024, 中部日本整形外科災害外科学会雑誌, 67


• 脆弱性骨折モデルにおける炭酸ガス経皮吸収療法の効果の検討

  近藤飛馬, 福井友章, 大江啓介, 隈部洋平, 山本裕也, 黒田良祐

  2024, 中部日本整形外科災害外科学会雑誌, 67


• インプラント周囲非定型大腿骨骨折の病態と治療戦略

  福井友章, 大江啓介, 隈部洋平, 松宮豊, 新倉隆宏, 黒田良祐

  2024, 中部日本整形外科災害外科学会雑誌, 67


• ウサギ大腿骨Masquelet法モデルを用いた自家骨とBMP-2の骨再生能の比較

  山本裕也, 福井友章, 大江啓介, 隈部洋平, 新倉隆宏, 黒田良祐

  2024, 中部日本整形外科災害外科学会雑誌, 67


• 短縮・変形を伴った脛骨偽関節に対して,Chipping法及びHexapod型創外固定を用いて緩徐矯正を行った一例

  高垣潤, 隈部洋平, 松宮豊, 福井友章, 大江啓介, 黒田良佑

  2024, 中部日本整形外科災害外科学会雑誌, 67


• 偽関節治療の基礎研究と臨床応用

  新倉 隆宏, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Apr. 2023, 日本整形外科学会雑誌, 97(4) (4), 252 - 260, Japanese


• Basic research and clinical application of fracture nonunion treatment

  新倉隆宏, 大江啓介, 黒田良祐

  2023, 日本整形外科学会雑誌, 97(4) (4)


• Reconstruction of Large Bone Defect: the Masquelet Technique

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2023, 臨床整形外科, 58(6) (6)


• New treatment method for fracture nonunion-autologous CD34-positive cell transplantation and bone morphogenetic protein-

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2023, 関節外科, 42(11) (11)


• Acceleration of fracture repair by low-intensity pulsed ultrasound

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2023, 超音波医学 Supplement, 50


• 脛骨慢性骨髄炎病的骨折に対しCLAPを併用し骨接合術と遊離皮弁術を同時に行った1例

  牟田口由紀子, 澤内健一, 大江啓介, 福井友章, 黒田良祐

  2023, 中部日本整形外科災害外科学会雑誌, 66(2) (2)


• 大腿骨近位部骨折の多くは既存骨折を有する

  岩倉崇, 大江啓介, 櫻井敦志, 澤村悟

  2023, 日本整形外科学会雑誌, 97(2) (2)


• 四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果

  新倉隆宏, 新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2023, 日本整形外科学会雑誌, 97(3) (3)


• 偽関節患者に対する自家末梢血CD34陽性細胞移植による骨・血管再生医療

  大江啓介, 新倉隆宏, 福井友章, 澤内健一, 黒田良祐

  2023, 日本整形外科学会雑誌, 97(3) (3)


• 患者立脚型QOL評価を用いた大腿骨および脛骨偽関節の術後成績の検討

  福井友章, 新倉隆宏, 新倉隆宏, 大江啓介, 澤内健一, 黒田良祐

  2023, 日本整形外科学会雑誌, 97(3) (3)


• Hip fracture templateは大腿骨近位部骨折手術における周術期合併症を減少させる

  脇貴洋, 石丸直人, 下川敏雄, 大江啓介, 水木真平, 大西潤, 官澤洋平, 矢野智則, 伊藤研二郎, 松島真司, 木南佐織

  2023, 日本整形外科学会雑誌, 97(2) (2)


• 下腿動脈欠損を伴う先天性絞扼輪症候群患者に生じた下腿慢性骨髄炎に対し遊離皮弁再建で救肢し得た1例

  古川惣一, 辻依子, 政岡浩輔, 大江啓介, 寺師浩人

  2023, 日本形成外科学会総会・学術集会プログラム・抄録集, 66th


• CLAPにおけるゲンタマイシンの血中濃度,排液中濃度と排液量の関係

  松宮豊, 大江啓介, 福井友章, 澤内健一, 新倉隆宏, 黒田良祐

  2023, 日本骨・関節感染症学会プログラム・抄録集, 46th


• 高濃度抗菌薬が骨髄由来細胞の増殖能および分化能に与える影響

  山本裕也, 大江啓介, 福井友章, 澤内健一, 吉川遼, 高瀬恭平, 西田亮太, 新倉隆宏, 圓尾明弘, 黒田良祐

  2023, 日本骨・関節感染症学会プログラム・抄録集, 46th


• 鎖骨遠位端骨折の術後に3人に1人が愁訴を残す-後ろ向き中期観察研究より-

  福本弦太, 脇貴洋, 大澤慎, 高見俊治, 矢野智則, 伊藤研二郎, 松島真司, 大江啓介

  2023, 日本整形外科学会雑誌, 97(3) (3)


• 当院における化膿性関節炎に対する持続局所抗菌薬灌流療法(CLAP)の治療成績

  大江啓介, 福井友章, 澤内健一, 松宮豊, 新倉隆宏, 黒田良祐

  2023, 日本骨・関節感染症学会プログラム・抄録集, 46th


• 持続局所抗菌薬潅流(CLAP)による骨折関連感染症の骨癒合経過-多施設研究-

  高原俊介, 高原俊介, 善家雄吉, 善家雄吉, 姫野大輔, 姫野大輔, 姫野大輔, 松本匡洋, 森井北斗, 大江啓介, 新倉隆宏, 圓尾明弘, 圓尾明弘

  2023, 日本骨・関節感染症学会プログラム・抄録集, 46th


• 骨SPECT/CTにおける偽関節モデルファントムを用いた金属インプラントのCT減弱補正に関する研究

  大江啓介, 福井友章, 澤内健一, 新倉隆宏, 新倉隆宏, 黒田良祐

  2023, 日本整形外科学会雑誌, 97(3) (3)


• Results of phase I/II clinical trial of BMP-2/artificial bone composite for patients of long bone fracture nonunions

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2023, 骨折(Web), 45(Supplement (CD-ROM)) (Supplement (CD-ROM))


• The effect of transcutaneous CO₂ application combined with low-intensity pulsed ultrasound on healing of femoral fractures in rats

  西田亮太, 澤内健一, 新倉隆宏, 福井友章, 大江啓介, 山本裕也, 高瀬恭平, 吉川遼, 黒田良祐

  2023, 骨折(Web), 45(Supplement (CD-ROM)) (Supplement (CD-ROM))


• A retrospective cohort study on treatment outcomes between atypical femoral fractures with and without bone-modifying drugs for cancer bone metastasis

  福井友章, 大江啓介, 澤内健一, 新倉隆宏, 新倉隆宏, 黒田良祐

  2023, 骨折(Web), 45(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Hip fracture template decreases perioperative complication rate under orthogeriatric co-management: a retrospective cohort study

  脇貴洋, 福本弦太, 大江啓介, 矢野智則, 伊藤研二郎, 松島真司

  2023, 骨折(Web), 45(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Effect of Low-Intensity Pulsed Ultrasound on osteogenic differentiation and angiogenesis of induced membrane-derived cells in vitro

  高瀬恭平, 福井友章, 大江啓介, 山本裕也, 西田亮太, 新倉隆宏, 黒田良祐

  2023, 骨折(Web), 45(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Treatment of continuous local antibiotics perfusion (CLAP) for chronic osteomyelitis in our hospital

  大江啓介, 福井友章, 黒田良祐, 新倉隆宏

  2023, 骨折(Web), 45(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Relationship between drug intervention of osteoporosis and bone mineral density around the stem in patients with femoral neck fractures: a multicenter prospective cohort study

  大江啓介, 福井友章, 澤内健一, 松宮豊, 黒田良祐, 新倉隆宏

  2023, 骨折(Web), 45(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Influence of high antibiotic concentrations on bone marrow-derived cells

  山本裕也, 大江啓介, 福井友章, 澤内健一, 高瀬恭平, 西田亮太, 新倉隆宏, 圓尾明弘, 黒田良祐

  2023, 骨折(Web), 45(Supplement (CD-ROM)) (Supplement (CD-ROM))


• A useful method to maintain bone graft in the Masquelet reconstruction surgery of femur bone defect

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2023, 骨折(Web), 45(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Treatment of Mycobacterium abscessus complex osteomyelitis and septic arthritis using continuous local antibiotics perfusion: a case report

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2023, 骨折(Web), 45(Supplement (CD-ROM)) (Supplement (CD-ROM))


• The status of acquisition of secondary fracture prevention management fee and additional fee for emergent fixation for hip fracture at our hip fracture center

  脇貴洋, 福本弦太, 大江啓介, 矢野智則, 伊藤研二郎, 松島真司

  2023, 骨折(Web), 45(Supplement (CD-ROM)) (Supplement (CD-ROM))


• 3D造形βTCP人工骨の生体活性の検討

  高瀬恭平, 福井友章, 大江啓介, 澤内健一, 吉川遼, 山本裕也, 西田亮太, 新倉隆宏, 黒田良祐

  2023, 日本整形外科学会雑誌, 97(8) (8)


• Masquelet法induced membrane由来細胞に対するLIPUSの骨分化促進効果の検討

  高瀬恭平, 福井友章, 大江啓介, 澤内健一, 吉川遼, 山本裕也, 西田亮太, 新倉隆宏, 黒田良祐

  2023, 日本整形外科学会雑誌, 97(8) (8)


• 廃用性骨萎縮・筋萎縮に対する炭酸ガス経皮吸収の予防効果

  西田亮太, 大江啓介, 福井友章, 澤内健一, 山本裕也, 高瀬恭平, 吉川遼, 新倉隆宏, 黒田良祐

  2023, 日本整形外科学会雑誌, 97(8) (8)


• 異なる抗菌薬濃度により骨髄由来細胞が受ける影響の検討

  山本裕也, 大江啓介, 福井友章, 澤内健一, 吉川遼, 高瀬恭平, 西田亮太, 新倉隆宏, 圓尾明弘, 黒田良祐

  2023, 日本整形外科学会雑誌, 97(8) (8)


• 前十字靭帯再建術後感染に対して持続局所抗菌薬灌流療法を行い,移植腱を温存し得たプロサッカー選手の1例

  吉田純伶, 松下雄彦, 大江啓介, 長井寛斗, 西田京平, 神崎至幸, 星野祐一, 黒田良祐

  2023, 中部日本整形外科災害外科学会雑誌, 66(5) (5)


• 四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2023, 中部日本整形外科災害外科学会雑誌, 66


• 特徴的画像所見を示した脛骨慢性骨髄炎の一例

  古川太河, 福井友章, 大江啓介, 新倉隆宏, 新倉隆宏, 黒田良祐

  2023, 中部日本整形外科災害外科学会雑誌, 66


• Mycobacterium abscessus complex感染による骨髄炎・化膿性関節炎を持続局所抗菌薬灌流で治療した一例

  藤田大樹, 新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2023, 中部日本整形外科災害外科学会雑誌, 66


• メッシュプレートを用いて内固定を行った母趾基節骨偽関節の2例

  大野裕也, 福井友章, 大江啓介, 澤内健一, 黒田良祐

  2023, 中部日本整形外科災害外科学会雑誌, 66


• 【CLAPによる骨軟部感染抑制の実際】CLAPの臨床 慢性骨髄炎、感染性偽関節に対するCLAPの応用

  新倉 隆宏, 大江 啓介

  (株)全日本病院出版会, Aug. 2022, Orthopaedics, 35(8) (8), 61 - 71, Japanese


• 転移性骨腫瘍(切迫骨折の治療) 寛骨臼転移性骨腫瘍に対して病巣掻爬後に内固定および骨セメント充填を行った3例

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2022, 骨折, 44(Suppl.) (Suppl.), S68 - S68, Japanese


• 高齢大腿骨頸部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化について 多施設共同研究

  大江 啓介, 新倉 隆宏, 福井 友章, 高原 俊介, 岩倉 崇, 角田 雅也, 櫻井 敦志, 正田 悦朗, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2022, 骨折, 44(Suppl.) (Suppl.), S217 - S217, Japanese


• 患者立脚型機能評価による上肢偽関節の治療成績の検討

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2022, 骨折, 44(Suppl.) (Suppl.), S268 - S268, Japanese


• 創外固定治療とMasquelet法のコラボレーション

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  日本四肢再建・創外固定学会, Apr. 2022, 日本四肢再建・創外固定学会雑誌, 33, 161 - 161, Japanese


• CT有限要素法を用いたreamer irrigator aspirator施行前後の大腿骨強度変化についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S878 - S878, Japanese


• 難治性骨折に対する自家CD34陽性細胞移植 医師主導治験の成果報告

  新倉 隆宏, 大江 啓介, 福井 友章, 松本 知之, 美舩 泰, 川本 篤彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S1027 - S1027, Japanese


• 難治性骨折に対する自家CD34陽性細胞移植-医師主導治験の成果報告-

  新倉隆宏, 大江啓介, 福井友章, 松本知之, 美舩泰, 川本篤彦, 黒田良祐

  2022, 日本整形外科学会雑誌, 96(3) (3)


• CT有限要素法を用いたreamer irrigator aspirator施行前後の大腿骨強度変化についての検討

  大江啓介, 新倉隆宏, 福井友章, 長宗高樹, 黒田良祐

  2022, 日本整形外科学会雑誌, 96(3) (3)


• Collaboration of external fixation and the Masquelet technique

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2022, 日本四肢再建・創外固定学会雑誌, 33


• CLAPによる骨軟部感染抑制の実際〈CLAPの臨床〉慢性骨髄炎,感染性偽関節に対するCLAPの応用

  新倉隆宏, 大江啓介

  2022, Monthly Book Orthopaedics, 35(8) (8)


• Masquelet法:Induced membrane由来細胞に対するLIPUSによる骨分化誘導

  高瀬恭平, 新倉隆宏, 福井友章, 大江啓介, 澤内健一, 吉川遼, 山本裕也, 黒田良祐

  2022, 日本整形外科学会雑誌, 96(8) (8)


• 偽関節治療の基礎研究と臨床応用

  新倉隆宏, 大江啓介, 福井友章, 松本知之, 美舩泰, 黒田良祐

  2022, 日本整形外科学会雑誌, 96(2) (2)


• 患者立脚型機能評価を用いた上肢偽関節の治療成績の検討

  福井友章, 新倉隆宏, 大江啓介, 黒田良祐

  2022, 日本整形外科学会雑誌, 96(3) (3)


• 非定型大腿骨骨折の病態と疫学

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2022, 日本整形外科学会雑誌, 96(2) (2)


• 先天性下腿偽関節症に対するMasquelet法を用いた治療経験

  坂田亮介, 新倉隆宏, 薩摩眞一, 小林大介, 衣笠真紀, 八尋俊輔, 北澤大也, 福井友章, 大江啓介, 黒田良祐

  2022, 日本整形外科学会雑誌, 96(2) (2)


• 高齢大腿骨頚部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について-多施設共同前向き観察研究-

  大江啓介, 新倉隆宏, 福井友章, 林申也, 酒井良忠, 高原俊介, 岩倉崇, 角田雅也, 柴原克紀, 正田悦朗, 黒田良祐

  2022, 日本整形外科学会雑誌, 96(3) (3)


• 自家CD34陽性細胞移植による難治性骨折治療-医師主導治験の報告-

  新倉隆宏, 福井友章, 大江啓介, 安田義, 渡部欣忍, 田島吾郎, 土井田稔, 山本哲司, 川本篤彦, 黒田良祐

  2022, 日本再生医療学会総会(Web), 21st


• 骨形成不全症患者に生じた非定型大腿骨骨折の1例

  上出將志, 大江啓介, 福井友章, 新倉隆宏, 黒田良祐

  2022, 中部日本整形外科災害外科学会雑誌, 65


• 大腿骨近位髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について多施設共同前向き観察研究

  大江啓介, 新倉隆宏, 福井友章, 林申也, 黒田良祐, 酒井良忠

  2022, 中部日本整形外科災害外科学会雑誌, 65


• Relationship between proximal femoral morphology and bone mineral density around the stem in patients with femoral neck fracture: a multicenter prospective cohort study

  大江啓介, 新倉隆宏, 福井友章, 高原俊介, 岩倉崇, 角田雅也, 櫻井敦志, 正田悦朗, 黒田良祐

  2022, 骨折(Web), 44(Supplement (CD-ROM)) (Supplement (CD-ROM))


• A report of 3 cases of internal fixation and bone cement augmentation after focal curettage for metastatic bone tumor of acetabulum

  大江啓介, 新倉隆宏, 福井友章, 黒田良祐

  2022, 骨折(Web), 44(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Evaluation of treatment results of upper limb nonunion by patient-reported outcome

  福井友章, 新倉隆宏, 大江啓介, 黒田良祐

  2022, 骨折(Web), 44(Supplement (CD-ROM)) (Supplement (CD-ROM))


• インプラント周囲非定型大腿骨骨折の病態と治療法について

  大江啓介, 福井友章, 澤内健一, 新倉隆宏, 黒田良祐

  2022, 日本股関節学会学術集会プログラム・抄録集, 49th


• Non-hypertrophic nonunionには骨分化能を有する細胞が存在し,E-BMP-2により骨・軟骨分化能が促進される

  吉川遼, 新倉隆宏, 福井友章, 大江啓介, 隈部洋平, 小田崇弘, 澤内健一, 高瀬恭平, 山本裕也, 酒井良忠, 黒田良祐

  2022, 日本整形外科学会雑誌, 96(8) (8)


• 炭酸ガス経皮吸収療法と低出力超音波パルス療法(LIPUS)の併用はラットの骨折治癒を促進する

  澤内健一, 新倉隆宏, 福井友章, 大江啓介, 山本裕也, 高瀬恭平, 吉川遼, 黒田良祐

  2022, 日本整形外科学会雑誌, 96(8) (8)


• 炭酸ガス経皮吸収による骨癒合促進

  新倉隆宏, 大江啓介, 福井友章, 澤内健一, 高瀬恭平, 黒田良祐

  2022, 日本整形外科学会雑誌, 96(8) (8)


• 骨組織由来細胞に対する高濃度抗菌薬の影響

  山本裕也, 新倉隆宏, 福井友章, 大江啓介, 高瀬恭平, 吉川遼, 澤内健一, 圓尾明弘, 黒田良祐

  2022, 日本整形外科学会雑誌, 96(8) (8)


• LIPUSのinduced membrane由来細胞に対する骨分化・血管新生促進効果の検討

  高瀬恭平, 新倉隆宏, 福井友章, 大江啓介, 澤内健一, 吉川遼, 山本裕也, 西田亮太, 黒田良祐

  2022, 移植(Web), 57(4) (4)


• 脛骨病的骨折を生じた骨アミロイドーシスの一例

  山本茜, 福井友章, 大江啓介, 新倉隆宏, 澤内健一, 黒田良祐

  2022, 中部日本整形外科災害外科学会雑誌, 65


• KLF15を介した筋萎縮の分子機構の解明

  平田悠, 野村和弘, 加藤大輔, 橘吉寿, 新倉隆宏, 内山奏, 細岡哲也, 細岡哲也, 福井友章, 大江啓介, 黒田良祐, 原雄二, 安達貴弘, 柴崎貢志, 和氣弘明, 小川渉

  2022, 糖尿病(Web), 65(Suppl) (Suppl)


• 非感染性偽関節に対する骨SPECTの定量評価(Quantitative evaluation of bone SPECT for uninfected nonunion)

  曽 菲比, 大江 啓介, 野上 宗伸, 犬養 純子, 立花 美保, 久保 和広, 福井 友章, 新倉 隆宏, 黒田 良祐, 村上 卓道

  (一社)日本核医学会, Oct. 2021, 核医学, 58(Suppl.) (Suppl.), S198 - S198, English


• 222nm UVCのヒトに対する安全性と有効性

  新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  (一社)日本環境感染学会, Sep. 2021, 日本環境感染学会総会プログラム・抄録集, 36回, 204 - 204, Japanese


• 糖尿病性骨症の病態と臨床疫学 整形外科から見た糖尿病患者の骨折とそのマネジメント

  新倉 隆宏, 西本 華子, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2021, 日本骨粗鬆症学会雑誌, 7(Suppl.1) (Suppl.1), 165 - 165, Japanese


• Klippel-Trenaunay症候群の患者に生じた大腿骨感染性偽関節に対する治療経験

  倉科 徹郎, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2021, 中部日本整形外科災害外科学会雑誌, 64(秋季学会) (秋季学会), 215 - 215, Japanese


• 222nm UVCのヒトに対する安全性と有効性

  新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  (一社)日本環境感染学会, Sep. 2021, 日本環境感染学会総会プログラム・抄録集, 36回, 204 - 204, Japanese


• 偽関節、感染性偽関節の基礎研究と臨床応用 偽関節患者への自家末梢血CD34陽性細胞移植

  大江 啓介, 新倉 隆宏, 福井 友章, 美舩 泰, 松本 知之, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1464 - S1464, Japanese


• 偽関節、感染性偽関節の基礎研究と臨床応用 Masquelet法の根幹をなすinduced membraneについての組織学的研究

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1465 - S1465, Japanese


• ヒトinduced membraneにおけるbone morphogenetic proteins(BMP)発現の検討

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 高瀬 恭平, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1689 - S1689, Japanese


• 偽関節、感染性偽関節の基礎研究と臨床応用 偽関節患者への自家末梢血CD34陽性細胞移植

  大江 啓介, 新倉 隆宏, 福井 友章, 美舩 泰, 松本 知之, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1464 - S1464, Japanese


• 偽関節、感染性偽関節の基礎研究と臨床応用 Masquelet法の根幹をなすinduced membraneについての組織学的研究

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1465 - S1465, Japanese


• ヒトinduced membraneにおけるbone morphogenetic proteins(BMP)発現の検討

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 高瀬 恭平, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1689 - S1689, Japanese


• Non-hypertrophic nonunion cellsの増殖能・骨分化能に対するE-BMP-2の効果の検討

  吉川 遼, 新倉 隆宏, 福井 友章, 大江 啓介, 高瀬 恭平, 澤内 健一, 小田 崇弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1814 - S1814, Japanese


• トップアスリートの外傷・障害とその治療

  黒田 良祐, 大江 啓介, 福井 友章, 新倉 隆宏

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S13 - S13, Japanese


• AFFの治療 インプラント周囲に発生した非定型大腿骨骨折について

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S30 - S30, Japanese


• 治療に難渋する骨折 偽関節に対する低出力超音波パルス療法の有効性

  李 相亮, 川崎 恵吉, 稲垣 克記, 福井 友章, 大江 啓介, 新倉 隆宏

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S40 - S40, Japanese


• 治療に難渋する骨折 偽関節治療への新たなアプローチ

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S41 - S41, Japanese


• 骨修飾薬使用中の悪性腫瘍骨転移患者に発生した非定型大腿骨骨折の治療経過に関する多施設共同研究

  福井 友章, 新倉 隆宏, 大江 啓介, 高原 俊介, 櫻井 敦志, 岩倉 崇, 正田 悦朗, 吉田 圭二, 伊藤 研二郎, 平中 崇文, 角田 雅也, 黒田 良祐

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S170 - S170, Japanese


• 有限要素法を用いたReamer Irrigator Aspirator施行前後の大腿骨強度評価の検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐, 長宗 高樹

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S198 - S198, Japanese


• 不安定型大腿骨転子部骨折における髄内釘径、長さがswing motionに及ぼす影響 模擬骨を用いた力学試験

  高原 俊介, 長宗 高樹, 大江 啓介, 野田 光昭, 市村 克仁, 西原 寛玄

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S141 - S141, Japanese


• 体外衝撃波療法は閉経後の骨粗鬆症を改善する

  井上 翔太, 脇本 祥夫, 李 昌欣, 畠山 隼平, 新倉 隆宏, 大江 啓介, 福井 友章, 黒木 裕士, 森山 英樹

  (一社)日本理学療法学会連合, Mar. 2021, 理学療法学, 47(Suppl.1) (Suppl.1), 159 - 159, Japanese


• 偽関節症例における骨SPECT定量評価についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S152 - S152, Japanese


• Masquelet法におけるinduced membraneのMRI評価についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S153 - S153, Japanese


• 骨修飾薬使用中の悪性腫瘍骨転移患者に発生した非定型大腿骨骨折に関する多施設共同研究

  福井 友章, 新倉 隆宏, 大江 啓介, 森下 雅之, 藤田 郁夫, 高原 俊介, 櫻井 敦志, 岩倉 崇, 吉田 圭二, 伊藤 研二郎, 正田 悦朗, 北田 真平, 平中 崇文, 角田 雅也, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S644 - S644, Japanese


• 【骨折に対する積極的保存療法 基礎編】難治性骨折に対する再生医療 自家末梢血CD34陽性細胞移植

  黒田 良祐, 新倉 隆宏, 大江 啓介, 福井 友章, 美舩 泰, 松本 知之

  (株)医学書院, Mar. 2021, 臨床整形外科, 56(3) (3), 241 - 245, Japanese


• 【骨折に対する積極的保存療法】LIPUSによる骨折の積極的保存療法 超音波骨折治療を有効活用するための照射部位ターゲティング

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (株)医学書院, Mar. 2021, 臨床整形外科, 56(3) (3), 261 - 266, Japanese


• 偽関節症例における骨SPECT定量評価についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S152 - S152, Japanese


• Masquelet法におけるinduced membraneのMRI評価についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S153 - S153, Japanese


• 骨修飾薬使用中の悪性腫瘍骨転移患者に発生した非定型大腿骨骨折に関する多施設共同研究

  福井 友章, 新倉 隆宏, 大江 啓介, 森下 雅之, 藤田 郁夫, 高原 俊介, 櫻井 敦志, 岩倉 崇, 吉田 圭二, 伊藤 研二郎, 正田 悦朗, 北田 真平, 平中 崇文, 角田 雅也, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S644 - S644, Japanese


• Fracture of the lateral process of the talus and peroneal tendon dislocation with lateral malleolar avulsion fracture

  福岡奈津子, 大江啓介, 櫻井敦志

  金原出版(株), Feb. 2021, 整形・災害外科, 64(2) (2), 231 - 234, Japanese


• Clinically applicable regeneration therapy: Transplantation of autologous peripheral blood CD34-positive cells to fracture nonunion patients

  新倉隆宏, 松本知之, 美舩泰, 福井友章, 大江啓介, 黒田良祐

  (株)メディカルレビュー社, Feb. 2021, 再生医療, 20(1) (1), 50 - 55, Japanese


• Low-intensity pulsed ultrasound treatment for fracture nonunion

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2021, 整形・災害外科, 64(1) (1)


• Fracture of the lateral process of the talus and peroneal tendon dislocation with lateral malleolar avulsion fracture

  福岡奈津子, 大江啓介, 櫻井敦志

  2021, 整形・災害外科, 64(2) (2)


• Regeneration Therapy to Treat Fracture Nonunion: Transplantation of Autologous Peripheral Blood CD34-Positive Cells

  黒田良祐, 新倉隆宏, 大江啓介, 福井友章, 美舩泰, 松本知之

  2021, 臨床整形外科, 56(3) (3)


• Clinically applicable regeneration therapy: Transplantation of autologous peripheral blood CD34-positive cells to fracture nonunion patients

  新倉隆宏, 松本知之, 美舩泰, 福井友章, 大江啓介, 黒田良祐

  2021, 再生医療, 20(1) (1)


• The treatment of metastatic bone tumor of the acetabulum with bone cement and screw fixation: case report

  葛原慎, 原仁美, 竹森俊幸, 大江啓介, 秋末敏宏, 秋末敏宏, 黒田良祐

  2021, 中部日本整形外科災害外科学会雑誌, 64(1) (1)


• 不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する

  平田悠, 野村和弘, 新倉隆宏, 橘吉寿, 加藤大輔, 加藤大輔, 内山奏, 福井友章, 大江啓介, 細岡哲也, 和氣弘明, 和氣弘明, 黒田良祐, 小川渉

  2021, 日本肥満学会・日本肥満症治療学会合同学術集会プログラム・抄録集, 41st-38th (Web)


• Masquelet法におけるinduced membraneのMRI評価についての検討

  大江啓介, 新倉隆宏, 福井友章, 黒田良祐

  2021, 日本整形外科学会雑誌, 95(2) (2)


• 偽関節症例における骨SPECT定量評価についての検討

  大江啓介, 新倉隆宏, 福井友章, 黒田良祐

  2021, 日本整形外科学会雑誌, 95(2) (2)


• 骨修飾薬使用中の悪性腫瘍骨転移患者に発生した非定型大腿骨骨折に関する多施設共同研究

  福井友章, 新倉隆宏, 大江啓介, 森下雅之, 藤田郁夫, 高原俊介, 櫻井敦志, 岩倉崇, 吉田圭二, 伊藤研二郎, 正田悦朗, 北田真平, 平中崇文, 角田雅也, 黒田良祐

  2021, 日本整形外科学会雑誌, 95(3) (3)


• 222nm UVCのヒトに対する安全性と有効性

  新倉隆宏, 福井友章, 大江啓介, 黒田良祐

  2021, 日本環境感染学会総会・学術集会(Web), 36th


• 整形外科から見た糖尿病患者の骨折とそのマネジメント

  新倉隆宏, 西本華子, 大江啓介, 福井友章, 黒田良祐

  2021, 日本骨粗鬆症学会雑誌, 7(Suppl.1 (CD-ROM)) (Suppl.1 (CD-ROM))


• Masquelet法の根幹をなすinduced membraneについての組織学的研究

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2021, 日本整形外科学会雑誌, 95(8) (8)


• 偽関節患者への自家末梢血CD34陽性細胞移植

  大江啓介, 新倉隆宏, 福井友章, 美舩泰, 松本知之, 黒田良祐

  2021, 日本整形外科学会雑誌, 95(8) (8)


• Non-hypertrophic nonunion cellsの増殖能・骨分化能に対するE-BMP-2の効果の検討

  吉川遼, 新倉隆宏, 福井友章, 大江啓介, 高瀬恭平, 澤内健一, 小田崇弘, 黒田良祐

  2021, 日本整形外科学会雑誌, 95(8) (8)


• Masquelet法induced membrane由来細胞に対するLIPUSによる骨分化誘導

  高瀬恭平, 新倉隆宏, 福井友章, 大江啓介, 小田崇弘, 澤内健一, 吉川遼, 黒田良祐

  2021, 日本整形外科学会雑誌, 95(8) (8)


• ヒトinduced membraneにおけるbone morphogenetic proteins(BMP)発現の検討

  小田崇弘, 新倉隆宏, 福井友章, 大江啓介, 澤内健一, 吉川遼, 高瀬恭平, 黒田良祐

  2021, 日本整形外科学会雑誌, 95(8) (8)


• Klippel-Trenaunay症候群の患者に生じた大腿骨感染性偽関節に対する治療経験

  倉科徹郎, 福井友章, 大江啓介, 新倉隆宏, 黒田良祐

  2021, 中部日本整形外科災害外科学会雑誌, 64


• Utilization of mechanical stress by physical agents to treat fractures and osteoporosis

  井上翔太, 井上翔太, 畠山隼平, 畠山隼平, 青木仁, 黒木裕士, 新倉隆宏, 大江啓介, 福井友章, 黒田良祐, 秋末敏宏, 森山英樹

  2021, 日本生体医工学会大会プログラム・抄録集(Web), 60th


• The pathophysiology of periprosthetic atypical femoral fractures

  大江啓介, 新倉隆宏, 福井友章, 黒田良祐

  2021, 骨折(Web), 43(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Efficacy of low-intensity pulsed ultrasound treatment for bone healing of nonunion

  李相亮, 李相亮, 川崎恵吉, 稲垣克記, 福井友章, 大江啓介, 新倉隆宏

  2021, 骨折(Web), 43(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Influence of cephalomedullary nail diameter and length on intra-medullary swing motion in the fixation for unstable pertrochanteric fractures; Biomechanical analysis in Sawbones.

  高原俊介, 長宗高樹, 大江啓介, 野田光昭, 市村克仁, 西原寛玄

  2021, 骨折(Web), 43(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Sports injuries of top athletes and their treatments

  黒田良祐, 大江啓介, 福井友章, 新倉隆宏

  2021, 骨折(Web), 43(Supplement (CD-ROM)) (Supplement (CD-ROM))


• New approach to the treatment of fracture nonunion

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2021, 骨折(Web), 43(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Examination of femur strength evaluation pre / post Reamer Irrigator Aspirator using the finite element method

  大江啓介, 新倉隆宏, 福井友章, 黒田良祐, 長宗高樹

  2021, 骨折(Web), 43(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Multicenter study on atypical femoral fractures in patients using bone modifying agents for bone metastasis

  福井友章, 新倉隆宏, 大江啓介, 高原俊介, 櫻井敦志, 岩倉崇, 正田悦朗, 吉田圭二, 伊藤研二郎, 平中崇文, 角田雅也, 黒田良祐

  2021, 骨折(Web), 43(Supplement (CD-ROM)) (Supplement (CD-ROM))


• Quantitative evaluation of bone SPECT for uninfected nonunion

  曽菲比, 大江啓介, 野上宗伸, 犬養純子, 立花美保, 久保和広, 福井友章, 新倉隆宏, 黒田良祐, 村上卓道

  2021, 核医学(Web), 58(Supplement) (Supplement)


• 大腿骨転子部骨折におけるshort femoral nailの髄内挙動 模擬骨を用いた力学試験

  高原 俊介, 市村 克仁, 西原 寛玄, 長宗 高樹, 大江 啓介, 野田 光昭

  (一社)日本骨折治療学会, Jan. 2021, 骨折, 43(1) (1), 41 - 44, Japanese


• Intra-medullary nail motion in the fixation for trochanteric femoral fracture with short femoral nail-Biomechanical analysis in sawbones-

  高原俊介, 市村克仁, 西原寛玄, 長宗高樹, 大江啓介, 野田光昭

  2021, 骨折(Web), 43(1) (1)


• The treatment of metastatic bone tumor of the acetabulum with bone cement and screw fixation: case report

  葛原慎, 原仁美, 竹森俊幸, 大江啓介, 秋末敏宏, 秋末敏宏, 黒田良祐

  (一社)中部日本整形外科災害外科学会, Jan. 2021, 中部日本整形外科災害外科学会雑誌, 64(1) (1), 73 - 74, Japanese


• 偽関節-どうしてこうなったか,なったらどうするか-

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  (一社)中部日本整形外科災害外科学会, 2021, 中部日本整形外科災害外科学会雑誌, 64(春季学会) (春季学会), 15 - 15, Japanese


• 膀胱癌手術後に両下腿のwell leg compartment syndrome(WLCS)を生じた一例

  名古竜平, 大江啓介, 福井友章, 黒田良祐, 新倉隆宏

  (一社)中部日本整形外科災害外科学会, 2021, 中部日本整形外科災害外科学会雑誌, 64(春季学会) (春季学会), 135 - 135, Japanese


• Low-intensity pulsed ultrasound treatment for fracture nonunion

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  金原出版(株), Jan. 2021, 整形・災害外科, 64(1) (1), 61 - 69, Japanese


• 大腿骨転子部骨折におけるshort femoral nailの髄内挙動 模擬骨を用いた力学試験

  高原 俊介, 市村 克仁, 西原 寛玄, 長宗 高樹, 大江 啓介, 野田 光昭

  (一社)日本骨折治療学会, Jan. 2021, 骨折, 43(1) (1), 41 - 44, Japanese


• Regeneration Therapy to Treat Fracture Nonunion: Transplantation of Autologous Peripheral Blood CD34-Positive Cells

  黒田良祐, 新倉隆宏, 大江啓介, 福井友章, 美舩泰, 松本知之

  (株)医学書院, 2021, 臨床整形外科, 56(3) (3), 241 - 245, Japanese


• Targeting of the Low-intensity Pulsed Ultrasound Application for an Effective Use

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  (株)医学書院, 2021, 臨床整形外科, 56(3) (3), 261 - 266, Japanese


• 不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する

  平田 悠, 野村 和弘, 新倉 隆宏, 橘 吉寿, 加藤 大輔, 内山 奏, 福井 友章, 大江 啓介, 細岡 哲也, 和氣 弘明, 黒田 良祐, 小川 渉

  日本筋学会, Dec. 2020, 日本筋学会学術集会プログラム・抄録集, 6回, 46 - 46, Japanese


• 寛骨臼の転移性骨腫瘍に対して骨セメント充填及びスクリューによる内固定を行った2例

  葛原 慎, 河本 旭哉, 竹森 俊幸, 大江 啓介, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 95 - 95, Japanese


• 上腕骨インプラント周囲骨折後にballooning変形を起こした偽関節の1例

  松宮 豊, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 157 - 157, Japanese


• 下肢難治性骨折に対する細胞治療

  黒田 良祐, 新倉 隆宏, 福井 友章, 大江 啓介, 松本 知之

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S36 - S36, Japanese


• 骨折に対する積極的保存療法(臨床編)第1部 LIPUS照射部位ターゲティング

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S40 - S40, Japanese


• 骨転移症例に対する骨折治療戦略 骨修飾薬使用中の癌骨転移患者に発生した非定型大腿骨骨折についての多施設共同研究

  福井 友章, 新倉 隆宏, 大江 啓介, 高原 俊介, 櫻井 敦志, 岩倉 崇, 吉田 圭二, 伊藤 研二郎, 正田 悦朗, 北田 真平, 平中 崇文, 角田 雅也, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S70 - S70, Japanese


• Masquelet法におけるinduced membraneのMRI評価についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S121 - S121, Japanese


• Masquelet法におけるinduced membraneの患者検体を用いた組織学的検討

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S121 - S121, Japanese


• Masquelet法におけるinduced membraneはpseudo-synovial membraneか?

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S122 - S122, Japanese


• 大腿骨転子部骨折におけるshort femoral nailの髄内挙動 模擬骨を用いた力学試験

  高原 俊介, 長宗 高樹, 大江 啓介, 野田 光昭, 市村 克仁, 西原 寛玄, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S129 - S129, Japanese


• 1型糖尿病ラット骨折モデルにおける炭酸ガス経皮吸収による骨折治癒促進効果の検討

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 吉川 遼, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S146 - S146, Japanese


• 偽関節における骨SPECTを用いた定量評価の試み

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S366 - S366, Japanese


• 卵巣摘出ラット骨粗鬆症モデルにおける炭酸ガス経皮吸収による骨粗鬆症改善効果の検討

  澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 吉川 遼, 小田 崇弘, 隈部 洋平, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1684 - S1684, Japanese


• Reamer irrigator aspirator(RIA)産物から得た細胞の骨分化に対するlow-intensity pulsed ultrasound(LIPUS)の効果

  澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 吉川 遼, 小田 崇弘, 隈部 洋平, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1685 - S1685, Japanese


• ウサギを用いた222nm紫外線術野照射の安全性の検討

  福井 友章, 新倉 隆宏, 小田 崇弘, 隈部 洋平, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1713 - S1713, Japanese


• 炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおける骨折治癒を促進させる

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 隈部 洋平, 澤内 健一, 吉川 遼, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1802 - S1802, Japanese


• 骨折治癒過程を超音波の周波数特性により推定する試み

  大江 啓介, 隈部 洋平, 新倉 隆宏, 福井 友章, 黒田 良祐, 畑 豊, 森本 雅和, 八木 直美, 小矢 美晴

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1918 - S1918, Japanese


• 男性骨粗鬆症モデルラットに対する炭酸ガス経皮吸収の影響に関する検討

  吉川 遼, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 小田 崇弘, 隈部 洋平, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1956 - S1956, Japanese


• 不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する

  平田 悠, 野村 和弘, 新倉 隆宏, 橘 吉寿, 加藤 大輔, 内山 奏, 福井 友章, 大江 啓介, 細岡 哲也, 和氣 弘明, 黒田 良祐, 小川 渉

  (一社)日本内分泌学会, Aug. 2020, 日本内分泌学会雑誌, 96(1) (1), 248 - 248, Japanese


• 不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する

  平田 悠, 野村 和弘, 新倉 隆宏, 橘 吉寿, 加藤 大輔, 内山 奏, 福井 友章, 大江 啓介, 細岡 哲也, 和氣 弘明, 黒田 良祐, 小川 渉

  (一社)日本糖尿病学会, Aug. 2020, 糖尿病, 63(Suppl.1) (Suppl.1), S - 238, Japanese


• 不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する

  平田 悠, 野村 和弘, 新倉 隆宏, 橘 吉寿, 加藤 大輔, 内山 奏, 福井 友章, 大江 啓介, 細岡 哲也, 和氣 弘明, 黒田 良祐, 小川 渉

  日本臨床分子医学会, Apr. 2020, 日本臨床分子医学会学術総会プログラム・抄録集, 57回, 58 - 58, Japanese


• Basic research for acceleration of fracture repair to translate to clinical application

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  (株)メジカルビュー社, Apr. 2020, 関節外科, 39(4月増刊) (4月増刊), 145 - 150, Japanese


• 髄内釘のコンプレッション機構を利用し、自家骨移植なしで治療した上腕骨骨幹部偽関節の一例

  福本 弦太, 新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 271 - 271, Japanese


• 外傷診療におけるCAOSの応用 難治骨折治療における3D実寸大骨モデルの応用

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  日本CAOS研究会・日本最小侵襲整形外科学会, Mar. 2020, 日本CAOS研究会・日本最小侵襲整形外科学会プログラム・抄録集, 14回・26回, 72 - 72, Japanese


• 炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる 臨床試験の報告

  新倉 隆宏, 岩倉 崇, 李 相亮, 大江 啓介, 福井 友章, 酒井 良忠, 秋末 敏宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1040 - S1040, Japanese


• The effect of transcutaneous CO₂ application on distraction osteogenesis of rabbit tibia

  隈部洋平, 新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  日本創外固定・骨延長学会, Mar. 2020, 日本創外固定・骨延長学会雑誌, 31, 352 - 352, Japanese


• 健常人における222 nmUVC照射の安全性と殺菌効果の検討

  福井 友章, 新倉 隆宏, 小田 崇弘, 隈部 洋平, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(2) (2), S160 - S160, Japanese


• 日本人におけるreamer irrigator aspirator(RIA)の使用経験とRIAリーマー径についての検討

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S949 - S949, Japanese


• DBMを利用した骨欠損や偽関節の治療

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S579 - S579, Japanese


• 大腿骨頸部骨折の術後CT画像評価方法の検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐, 櫻井 敦志, 岩倉 崇

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S904 - S904, Japanese


• Basic research for acceleration of fracture repair to translate to clinical application

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2020, 関節外科, 39


• The effect of transcutaneous CO₂ application on distraction osteogenesis of rabbit tibia

  隈部洋平, 新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2020, 日本創外固定・骨延長学会雑誌, 31


• 健常人における222nmUVC照射の安全性と殺菌効果の検討

  福井友章, 新倉隆宏, 小田崇弘, 隈部洋平, 大江啓介, 黒田良祐

  2020, 日本整形外科学会雑誌, 94(2) (2)


• Reamer irrigator aspirator(RIA)産物から得た細胞の骨分化に対するlow-intensity pulsed ultrasound(LIPUS)の効果

  澤内健一, 新倉隆宏, 福井友章, 大江啓介, 吉川遼, 小田崇弘, 隈部洋平, 黒田良祐

  2020, 超音波骨折治療研究会プログラム・抄録集, 23rd


• 不動化はCa²⁺シグナルの減弱を通じて筋萎縮を制御する

  平田悠, 野村和弘, 新倉隆宏, 橘吉寿, 加藤大輔, 加藤大輔, 内山奏, 福井友章, 大江啓介, 細岡哲也, 和氣弘明, 和氣弘明, 黒田良祐, 小川渉

  2020, 日本内分泌学会雑誌, 96(1) (1)


• ウサギを用いた222nm紫外線術野照射の安全性の検討

  福井友章, 新倉隆宏, 小田崇弘, 隈部洋平, 大江啓介, 黒田良祐

  2020, 日本整形外科学会雑誌, 94(8) (8)


• Reamer irrigator aspirator(RIA)産物から得た細胞の骨分化に対するlow-intensity pulsed ultrasound(LIPUS)の効果

  澤内健一, 新倉隆宏, 福井友章, 大江啓介, 吉川遼, 小田崇弘, 隈部洋平, 黒田良祐

  2020, 日本整形外科学会雑誌, 94(8) (8)


• 骨折治癒過程を超音波の周波数特性により推定する試み

  大江啓介, 隈部洋平, 新倉隆宏, 福井友章, 黒田良祐, 畑豊, 森本雅和, 八木直美, 小矢美晴

  2020, 日本整形外科学会雑誌, 94(8) (8)


• 卵巣摘出ラット骨粗鬆症モデルにおける,炭酸ガス経皮吸収による骨粗鬆症改善効果の検討

  澤内健一, 新倉隆宏, 福井友章, 大江啓介, 吉川遼, 小田崇弘, 隈部洋平, 黒田良祐

  2020, 日本整形外科学会雑誌, 94(8) (8)


• 炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおける骨折治癒を促進させる

  小田崇弘, 新倉隆宏, 福井友章, 大江啓介, 隈部洋平, 澤内健一, 吉川遼, 酒井良忠, 黒田良祐

  2020, 日本整形外科学会雑誌, 94(8) (8)


• 男性骨粗鬆症モデルラットに対する炭酸ガス経皮吸収の影響に関する検討

  吉川遼, 新倉隆宏, 福井友章, 大江啓介, 澤内健一, 小田崇弘, 隈部洋平, 酒井良忠, 黒田良祐

  2020, 日本整形外科学会雑誌, 94(8) (8)


• 寛骨臼の転移性骨腫瘍に対して骨セメント充填及びスクリューによる内固定を行った2例

  葛原慎, 河本旭哉, 竹森俊幸, 大江啓介, 秋末敏宏, 秋末敏宏, 黒田良祐

  2020, 中部日本整形外科災害外科学会雑誌, 63


• 上腕骨インプラント周囲骨折後にballooning変形を起こした偽関節の1例

  松宮豊, 大江啓介, 福井友章, 新倉隆宏, 黒田良祐

  2020, 中部日本整形外科災害外科学会雑誌, 63


• 不動化はCa²⁺シグナルの減弱を通じて筋萎縮を制御する

  平田悠, 野村和弘, 新倉隆宏, 橘吉寿, 加藤大輔, 加藤大輔, 内山奏, 福井友章, 大江啓介, 細岡哲也, 和氣弘明, 和氣弘明, 黒田良祐, 小川渉

  2020, 日本抗加齢医学会総会プログラム・抄録集, 20th


• 不動化はCa²⁺シグナルの減弱を通じて筋萎縮を制御する

  平田悠, 野村和弘, 新倉隆宏, 橘吉寿, 加藤大輔, 加藤大輔, 内山奏, 福井友章, 大江啓介, 細岡哲也, 和氣弘明, 和氣弘明, 黒田良祐, 小川渉

  2020, 糖尿病(Web), 63(Suppl) (Suppl)


• DBMを利用した骨欠損や偽関節の治療

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2020, 日本整形外科学会雑誌, 94(3) (3)


• 髄内釘のコンプレッション機構を利用し,自家骨移植なしで治療した上腕骨骨幹部偽関節の一例

  福本弦太, 新倉隆宏, 福井友章, 大江啓介, 黒田良祐

  2020, 中部日本整形外科災害外科学会雑誌, 63


• 日本人におけるreamer irrigator aspirator(RIA)の使用経験とRIAリーマー径についての検討

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2020, 日本整形外科学会雑誌, 94(3) (3)


• 大腿骨頚部骨折の術後CT画像評価方法の検討

  大江啓介, 新倉隆宏, 福井友章, 黒田良祐, 櫻井敦志, 岩倉崇

  2020, 日本整形外科学会雑誌, 94(3) (3)


• 炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる-臨床試験の報告-

  新倉隆宏, 岩倉崇, 李相亮, 大江啓介, 福井友章, 酒井良忠, 秋末敏宏, 黒田良祐

  2020, 日本整形外科学会雑誌, 94(3) (3)


• 不動化はCa²⁺シグナルの減弱を通じて筋萎縮を制御する

  平田悠, 野村和弘, 新倉隆宏, 橘吉寿, 加藤大輔, 内山奏, 福井友章, 大江啓介, 細岡哲也, 和氣弘明, 黒田良祐, 小川渉

  2020, 日本筋学会学術集会プログラム・抄録集, 6th


• Intra-medullary antibiotics perfusion(iMAP)から屍体脛骨髄内に投与された抗菌薬の薬物動態

  圓尾 明弘, 福井 友章, 大江 啓介, 新倉 隆宏, 善家 雄吉

  (一社)日本骨折治療学会, Jan. 2020, 骨折, 42(1) (1), 1 - 5, Japanese


• Intra-medullary distribution of antibiotics by intra-medullary antibiotics perfusion(iMAP)-A cadaver study-

  圓尾明弘, 福井友章, 大江啓介, 新倉隆宏, 善家雄吉

  2020, 骨折(Web), 42(1) (1)


• Intra-medullary nail motion in the fixation for trochanteric femoral fracture with short femoral nail; Biomechanical analysis in Sawbones.

  高原俊介, 長宗高樹, 大江啓介, 野田光昭, 市村克仁, 西原寛玄, 福井友章, 新倉隆宏, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Targeting of low-intensity pulsed ultrasound treatment

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Histological analysis of the induced membrane of the patients whose bone defects were treated by the Masquelet technique

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Multicenter study on atypical femoral fractures in patients with bone metastases using bone modifying agents

  福井友章, 新倉隆宏, 大江啓介, 高原俊介, 櫻井敦志, 岩倉崇, 吉田圭二, 伊藤研二郎, 正田悦朗, 北田真平, 平中崇文, 角田雅也, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Investigation of the effect of topical cutaneous CO2 application on fracture healing in streptozotocin-induced diabetic rats

  小田崇弘, 新倉隆宏, 福井友章, 大江啓介, 吉川遼, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Assessment of induced membrane formation by magnetic resonance imaging in Masquelet reconstruction surgery

  大江啓介, 新倉隆宏, 福井友章, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Cell therapy for patients with femoral and tibial Nonunion

  黒田良祐, 新倉隆宏, 福井友章, 大江啓介, 松本知之

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Quantitative Bone SPECT imaging for non union

  大江啓介, 新倉隆宏, 福井友章, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Is the Masquelet induced membrane a pseudo-synovial membrane?

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Reamer irrigator aspirator(RIA)産物から得た細胞の骨分化に対するlow-intensity pulsed ultrasound(LIPUS)の効果

  澤内健一, 新倉隆宏, 福井友章, 大江啓介, 吉川遼, 小田崇弘, 隈部洋平, 黒田良祐

  2020, 超音波骨折治療研究会プログラム・抄録集, 23rd


• 超音波画像を用いた骨癒合の評価

  清水風, 小矢美晴, 大江啓介, 隈部洋平, 福井友章, 新倉隆宏

  2020, 電気関係学会関西連合大会(Web), 2020


• 骨格筋量制御におけるKLF15の機能の解析

  平田 悠, 野村 和弘, 小林 憲太, 岡本 士毅, 箕越 靖彦, 今村 道博, 武田 伸一, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 細岡 哲也, 小川 渉

  (一社)日本肥満学会, Oct. 2019, 肥満研究, 25(Suppl.) (Suppl.), 260 - 260, Japanese


• 自己免疫性多内分泌腺症候群2型による続発性骨軟化症にて両側脛骨近位端骨折を生じた1例

  中川 大輔, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(秋季学会) (秋季学会), 109 - 109, Japanese


• 炭酸ガス経皮吸収はウサギ脛骨骨延長術における骨形成を促進する

  隈部 洋平, 新倉 隆宏, 福井 友章, 高原 俊介, 黒岩 祐, 新倉 路生, 大江 啓介, 小田 崇弘, 澤内 健一, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1622 - S1622, Japanese


• 炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおいて骨癒合を促進させる

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 新倉 路生, 黒岩 祐, 隈部 洋平, 澤内 健一, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1755 - S1755, Japanese


• 非定型大腿骨骨折術後偽関節の治療経験

  新倉 隆宏, 西本 華子, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2019, 日本骨粗鬆症学会雑誌, 5(Suppl.1) (Suppl.1), 457 - 457, Japanese


• 腫瘍性骨軟化症による大腿骨頸部病的骨折をきたした1例

  井上 悠, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(5) (5), 958 - 958, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  澤内 健一, 平田 悠, 野村 和弘, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 小川 渉

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1749 - S1749, Japanese


• 【大腿骨転子部骨折 もう怖くない不安定型の手術テクニック】手術法解説 偽関節とならないための転子下骨折の整復法 ワイヤリングの適応を含めて

  大江 啓介

  (株)メディカ出版, Aug. 2019, 整形外科Surgical Technique, 9(4) (4), 430 - 437, Japanese


• 解剖用屍体におけるiMAPから髄内に投与された抗菌薬の薬物動態の検討

  圓尾 明弘, 福井 友章, 大江 啓介, 新倉 隆宏, 善家 雄吉

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S101 - S101, Japanese


• Masquelet法で治療した患者におけるinduced membraneの組織学的評価

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S167 - S167, Japanese


• 下肢長管骨偽関節に対するロッキングプレートを用いた手術の治療成績

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S170 - S170, Japanese


• 文書を用いた患者説明によるLIPUSコンプライアンス向上の効果

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S378 - S378, Japanese


• 大腿骨頸部骨折の術後CT画像評価方法の検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐, 岩倉 崇, 櫻井 敦志

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S420 - S420, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  平田 悠, 野村 和弘, 小林 憲太, 岡本 士毅, 箕越 靖彦, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 細岡 哲也, 小川 渉

  日本臨床分子医学会, Apr. 2019, 日本臨床分子医学会学術総会プログラム・抄録集, 56回, 71 - 71, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  平田 悠, 野村 和弘, 千賀 陽子, 岡田 裕子, 小林 憲太, 岡本 士毅, 箕越 靖彦, 今村 道博, 武田 伸一, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 細岡 哲也, 小川 渉

  (一社)日本糖尿病学会, Apr. 2019, 糖尿病, 62(Suppl.1) (Suppl.1), S - 149, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  平田 悠, 野村 和弘, 千賀 陽子, 岡田 裕子, 小林 憲太, 岡本 士毅, 箕越 靖彦, 今村 道博, 武田 伸一, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 細岡 哲也, 小川 渉

  (一社)日本糖尿病学会, Apr. 2019, 糖尿病, 62(Suppl.1) (Suppl.1), S - 149, Japanese


• 整形外傷領域における再生医療

  新倉 隆宏, 松本 知之, 美舩 泰, 福井 友章, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S113 - S113, Japanese


• 坐骨結節裂離骨折偽関節に対し手術加療を行った1例

  中松 裕太, 新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(春季学会) (春季学会), 200 - 200, Japanese


• 患者立脚型機能評価による大腿骨・脛骨偽関節の治療成績の検討

  福井 友章, 新倉 隆宏, 岩倉 崇, 李 相亮, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(3) (3), S963 - S963, Japanese


• Reamer irrigator aspirator(RIA)を日本人患者に使用した臨床経験

  新倉 隆宏, 大江 啓介, 福井 友章, 工藤 健史, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(3) (3), S965 - S965, Japanese


• 非定型大腿骨骨折術後偽関節の治療経験

  新倉隆宏, 西本華子, 大江啓介, 福井友章, 黒田良祐

  2019, 日本骨粗鬆症学会雑誌, 5(Suppl.1) (Suppl.1)


• 腫瘍性骨軟化症による大腿骨頚部病的骨折をきたした1例

  井上悠, 福井友章, 大江啓介, 新倉隆宏, 黒田良祐

  2019, 中部日本整形外科災害外科学会雑誌, 62(5) (5)


• 骨格筋量制御におけるKLF15の機能の解析

  平田悠, 野村和弘, 千賀陽子, 岡田裕子, 小林憲太, 岡本士毅, 岡本士毅, 箕越靖彦, 今村道博, 武田伸一, 小田崇弘, 福井友章, 大江啓介, 新倉隆宏, 黒田良祐, 細岡哲也, 小川渉

  2019, 糖尿病(Web), 62(Suppl) (Suppl)


• 患者立脚型機能評価による大腿骨・脛骨偽関節の治療成績の検討

  福井友章, 新倉隆宏, 岩倉崇, 李相亮, 李相亮, 大江啓介, 黒田良祐

  2019, 日本整形外科学会雑誌, 93(3) (3)


• Reamer irrigator aspirator(RIA)を日本人患者に使用した臨床経験

  新倉隆宏, 大江啓介, 福井友章, 工藤健史, 黒田良祐

  2019, 日本整形外科学会雑誌, 93(3) (3)


• 骨格筋量制御におけるKLF15の機能の解析

  澤内健一, 平田悠, 野村和弘, 小田崇弘, 福井友章, 大江啓介, 新倉隆宏, 黒田良祐, 小川渉

  2019, 日本整形外科学会雑誌, 93(8) (8)


• 坐骨結節裂離骨折偽関節に対し手術加療を行った1例

  中松裕太, 新倉隆宏, 福井友章, 大江啓介, 黒田良祐

  2019, 中部日本整形外科災害外科学会雑誌, 62


• ウサギ骨延長術モデルにおける炭酸ガス経皮吸収の骨形成促進効果について

  隈部洋平, 新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2019, 移植(Web), 54(4-5) (4-5)


• Surgical treatment with locking plate for lower limb nonunion

  福井友章, 新倉隆宏, 大江啓介, 黒田良祐

  2019, 骨折(Web), 41(Supplement) (Supplement)


• Pharmacokinetics of intramedullary administrated antibiotics infused from iMAP at Cadaver

  圓尾明弘, 福井友章, 大江啓介, 新倉隆宏, 善家雄吉

  2019, 骨折(Web), 41(Supplement) (Supplement)


• Histological analysis of the induced membrane of the patients whose bone defects were treated by the Masquelet technique

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2019, 骨折(Web), 41(Supplement) (Supplement)


• Investigation of postoperative CT image evaluation method of femoral neck fracture

  大江啓介, 新倉隆宏, 福井友章, 黒田良祐, 岩倉崇, 櫻井敦志

  2019, 骨折(Web), 41(Supplement) (Supplement)


• Effect of explanation with document for improvement of patient compliance for low-intensity pulsed ultrasound (LIPUS) treatment

  福井友章, 新倉隆宏, 大江啓介, 黒田良祐

  2019, 骨折(Web), 41(Supplement) (Supplement)


• 体外衝撃波療法は閉経後の骨粗鬆症を改善する

  井上翔太, 脇本祥夫, 李昌欣, 畠山隼平, 新倉隆宏, 大江啓介, 福井友章, 黒木裕士, 森山英樹

  (公社)日本理学療法士協会, 2019, 日本基礎理学療法学会学術大会プログラム・抄録集(Web), 24th(Suppl.1) (Suppl.1), 159 - 159, Japanese


• 文書を用いた説明による超音波骨折治療器使用における患者コンプライアンス向上の試み

  福井友章, 大江啓介, 新倉隆宏, 黒田良祐

  2019, 超音波骨折治療研究会プログラム・抄録集, 22nd, 30(JA),30‐31(EN), Japanese


• 整形外傷領域における再生医療

  新倉 隆宏, 松本 知之, 美舩 泰, 福井 友章, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, 2019, 日本整形外科学会雑誌, 93(2) (2), S113 - S113, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  平田 悠, 野村 和弘, 小林 憲太, 岡本 士毅, 箕越 靖彦, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 細岡 哲也, 小川 渉

  日本臨床分子医学会, 2019, 日本臨床分子医学会学術総会プログラム・抄録集, 62(Suppl) (Suppl), 71 - 71, Japanese


• 【大腿骨転子部骨折 もう怖くない不安定型の手術テクニック】手術法解説 偽関節とならないための転子下骨折の整復法 ワイヤリングの適応を含めて

  大江 啓介

  (株)メディカ出版, 2019, 整形外科Surgical Technique, 9(4) (4), 430 - 437, Japanese


• 自己免疫性多内分泌腺症候群2型による続発性骨軟化症にて両側脛骨近位端骨折を生じた1例

  中川 大輔, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, 2019, 中部日本整形外科災害外科学会雑誌, 62(秋季学会) (秋季学会), 109 - 109, Japanese


• 炭酸ガス経皮吸収はウサギ脛骨骨延長術における骨形成を促進する

  隈部 洋平, 新倉 隆宏, 福井 友章, 高原 俊介, 黒岩 祐, 新倉 路生, 大江 啓介, 小田 崇弘, 澤内 健一, 黒田 良祐

  (公社)日本整形外科学会, 2019, 日本整形外科学会雑誌, 93(8) (8), S1622 - S1622, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  澤内 健一, 平田 悠, 野村 和弘, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 小川 渉

  (公社)日本整形外科学会, 2019, 日本整形外科学会雑誌, 40th-37th(8) (8), S1749 - S1749, Japanese


• 炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおいて骨癒合を促進させる

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 新倉 路生, 黒岩 祐, 隈部 洋平, 澤内 健一, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, 2019, 日本整形外科学会雑誌, 93(8) (8), S1755 - S1755, Japanese


• 外傷における人工骨の臨床 RIA産物と人工骨の混合移植による骨欠損の再建

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (株)医学書院, Dec. 2018, 臨床整形外科, 53(12) (12), 1087 - 1093, Japanese


• 技術革新に伴うマイクロサージャリーの適応変化 Masquelet法とReamer Irrigator Aspiratorを用いた骨欠損・難治骨折の治療

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本マイクロサージャリー学会, Dec. 2018, 日本マイクロサージャリー学会学術集会プログラム・抄録集, 45回, 128 - 128, Japanese


• 【骨粗鬆症診療の真の目的は何か?!-脆弱性骨折の予防と診療の最前線】脆弱性骨折の連鎖 ケーススタディから学ぶ

  新倉 隆宏, 岩倉 崇, 大江 啓介, 林 申也, 福井 友章, 西本 華子, 黒田 良祐

  (株)ライフメディコム, Oct. 2018, カレントテラピー, 36(10) (10), 970 - 979, Japanese


• 下肢偽関節手術後に低出力超音波パルスを使用した症例についての検討

  李 相亮, 新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2018, 骨折, 40(4) (4), 1107 - 1110, Japanese


• 同側大腿骨・脛骨開放性骨折後の感染に対してヨードコーティング腫瘍用人工膝関節置換を行った1例

  大澤 慎, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  中部日本整形外科災害外科学会, Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 292 - 292, Japanese


• 下肢偽関節手術後に低出力超音波パルスを使用した症例についての検討

  李 相亮, 新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2018, 骨折, 40(4) (4), 1107 - 1110, Japanese


• ヒトiPS細胞による軟骨内骨化を介した骨再生療法

  新倉 路生, 李 相亮, 福井 友章, 大江 啓介, 高原 俊介, 黒岩 祐, 隈部 洋平, 黒田 良祐, 新倉 隆宏

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1988 - S1988, Japanese


• ラット骨欠損モデルにおけるCO2経皮吸収の骨形成促進作用についての検討

  黒岩 祐, 新倉 隆宏, 高原 俊介, 李 相亮, 大江 啓介, 福井 友章, 新倉 路生, 隈部 洋平, 小田 崇弘, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1998 - S1998, Japanese


• 222nm紫外線照射の安全性と殺菌効果の検討

  福井 友章, 新倉 隆宏, 小田 崇弘, 隈部 洋平, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1757 - S1757, Japanese


• 組織再生における血管新生 炭酸ガス経皮吸収がラットの筋組織に及ぼす影響

  大江 啓介, 新倉 隆宏, 福井 友章, 黒岩 祐, 隈部 洋平, 小田 崇弘, 澤内 健一, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1877 - S1877, Japanese


• 患者立脚型機能評価を用いた下肢偽関節治療成績

  福井 友章, 大江 啓介, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jul. 2018, 骨折, 40(Suppl.) (Suppl.), S208 - S208, Japanese


• 日本人におけるReamer irrigator aspirator:(RIA)の使用経験

  大江 啓介, 福井 友章, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jul. 2018, 骨折, 40(Suppl.) (Suppl.), S450 - S450, Japanese


• 若年成人に発生した非定型大腿骨骨折の3例

  李 相亮, 大江 啓介, 福井 友章, 乾 淳幸, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jul. 2018, 骨折, 40(Suppl.) (Suppl.), S495 - S495, Japanese


• 上腕骨骨幹部骨折術後偽関節に対してMIPO法にて治療した2例

  栖田 慶仁, 大江 啓介, 福井 友章, 黒田 良祐, 新倉 隆宏

  (一社)中部日本整形外科災害外科学会, May 2018, 中部日本整形外科災害外科学会雑誌, 61(3) (3), 613 - 613, Japanese


• CO2経皮吸収はラット骨欠損モデルにおいて骨形成を促進させる

  小田 崇弘, 黒岩 祐, 高原 俊介, 新倉 路生, 隈部 洋平, 李 相亮, 大江 啓介, 岩倉 崇, 福井 友章, 酒井 良忠, 新倉 隆宏, 黒田 良祐

  (一社)日本移植学会, Feb. 2018, 移植, 52(6) (6), 581 - 581, Japanese


• 下肢偽関節手術後に低出力超音波パルスを使用した症例についての検討

  LEE S. Y., LEE S. Y., 新倉隆宏, 福井友章, 大江啓介, 黒田良祐

  2018, 骨折, 40(4) (4)


• RIA産物と人工骨の混合移植による骨欠損の再建

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2018, 臨床整形外科, 53(12) (12)


• Masquelet法とReamer Irrigator Aspiratorを用いた骨欠損・難治骨折の治療

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2018, 日本マイクロサージャリー学会学術集会プログラム・抄録集, 45th


• 超音波骨折治療におけるコンプライアンス向上のための試み(第2報)

  大江啓介, 福井友章, 黒田良祐, 新倉隆宏

  2018, 超音波骨折治療研究会プログラム・抄録集, 21st, 48(JA),48‐49(EN), Japanese


• 骨延長術における炭酸ガス経皮吸収の骨形成促進効果について

  隈部洋平, 新倉隆宏, 福井友章, 大江啓介, 高原俊介, 新倉路生, 黒岩祐, 小田崇弘, 黒田良祐

  2018, 日本再生医療学会総会(Web), 17th, ROMBUNNO.P‐03‐076 (WEB ONLY), Japanese


• 難治性骨折患者を対象とした自家末梢血CD34陽性細胞移植療法―医師主導治験の経験から―

  黒田良祐, 大江啓介, 福井友章, 新倉隆宏, 松本知之

  2018, 日本再生医療学会総会(Web), 17th, ROMBUNNO.SY‐35‐5 (WEB ONLY), Japanese


• 同側大腿骨・脛骨開放性骨折後の感染に対してヨードコーティング腫瘍用人工膝関節置換を行った1例

  大澤 慎, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 292 - 292, Japanese


• 222nm紫外線照射の安全性と殺菌効果の検討

  福井 友章, 新倉 隆宏, 小田 崇弘, 隈部 洋平, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, 2018, 日本整形外科学会雑誌, 92(8) (8), S1757 - S1757, Japanese


• 組織再生における血管新生 炭酸ガス経皮吸収がラットの筋組織に及ぼす影響

  大江 啓介, 新倉 隆宏, 福井 友章, 黒岩 祐, 隈部 洋平, 小田 崇弘, 澤内 健一, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, 2018, 日本整形外科学会雑誌, 92(8) (8), S1877 - S1877, Japanese


• インプラント周囲での非定型大腿骨骨折の1例

  田中 秀弥, 新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  中部日本整形外科災害外科学会, 2018, 中部日本整形外科災害外科学会雑誌, 61(春季学会) (春季学会), 114 - 114, Japanese


• 患者立脚型機能評価を含めた下肢偽関節治療経過の検討

  福井 友章, 岩倉 崇, 李 相亮, 大江 啓介, 黒田 良祐, 新倉 隆宏

  (公社)日本整形外科学会, 2018, 日本整形外科学会雑誌, 92(2) (2), S86 - S86, Japanese


• 222nm紫外線照射の安全性および殺菌効果

  福井 友章, 新倉 隆宏, 小田 崇弘, 隈部 洋平, 大江 啓介, 黒田 良祐

  日本骨・関節感染症学会, 2018, 日本骨・関節感染症学会プログラム・抄録集, 41st, 135 - 135, Japanese


• 日本人におけるreamer irrigator aspirator(RIA)の使用経験

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, 2018, 日本整形外科学会雑誌, 92(3) (3), S1238 - S1238, Japanese


• 患者立脚型機能評価を用いた下肢偽関節治療成績

  福井 友章, 大江 啓介, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, 2018, 骨折, 40(Supplement) (Supplement), S208 - S208, Japanese


• 日本人におけるReamer irrigator aspirator:(RIA)の使用経験

  大江 啓介, 福井 友章, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, 2018, 骨折, 40(Supplement) (Supplement), S450 - S450, Japanese


• 若年成人に発生した非定型大腿骨骨折の3例

  李 相亮, 大江 啓介, 福井 友章, 乾 淳幸, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, 2018, 骨折, 40(Supplement) (Supplement), S495 - S495, Japanese


• 上腕骨骨幹部骨折術後偽関節に対してMIPO法にて治療した2例

  栖田 慶仁, 大江 啓介, 福井 友章, 黒田 良祐, 新倉 隆宏

  中部日本整形外科災害外科学会, 2018, 中部日本整形外科災害外科学会雑誌, 61(3) (3), 613 - 613, Japanese


• ヒトiPS細胞による軟骨内骨化を介した骨再生療法

  新倉 路生, 李 相亮, 福井 友章, 大江 啓介, 高原 俊介, 黒岩 祐, 隈部 洋平, 黒田 良祐, 新倉 隆宏

  (公社)日本整形外科学会, 2018, 日本整形外科学会雑誌, 92(8) (8), S1988 - S1988, Japanese


• ラット骨欠損モデルにおけるCO2経皮吸収の骨形成促進作用についての検討

  黒岩 祐, 新倉 隆宏, 高原 俊介, 李 相亮, 大江 啓介, 福井 友章, 新倉 路生, 隈部 洋平, 小田 崇弘, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, 2018, 日本整形外科学会雑誌, 92(8) (8), S1998 - S1998, Japanese


• 【骨粗鬆症診療の真の目的は何か?!-脆弱性骨折の予防と診療の最前線】 脆弱性骨折の連鎖 ケーススタディから学ぶ

  新倉 隆宏, 岩倉 崇, 大江 啓介, 林 申也, 福井 友章, 西本 華子, 黒田 良祐

  (株)ライフメディコム, 2018, カレントテラピー, 36(10) (10), 970 - 979, Japanese


• 大腿骨転子部骨折術後合併症例に対する人工骨頭置換術についての検討

  櫻井敦志, 澤村悟

  (一社)日本骨折治療学会, 2017, 骨折, 39(2) (2), 348 - 351, Japanese

  [Refereed]

  Others


• 足部重症開放骨折に対して足部温存を行った1例

  小田崇弘, 大江啓介, 櫻井敦志, 高島良典, 澤村悟

  (一社)日本骨折治療学会, 2017, 骨折, 39(2) (2), 444 - 447, Japanese

  [Refereed]

  Others


• 【特殊な機器を用いた治療法】 炭酸ガス経皮吸収治療

  酒井良忠, 上羽岳志, Kuroda Ryosuke

  日本運動器科学会, 2017, 運動器リハビリテーション, 28(1) (1), 16 - 24, Japanese

  [Refereed]

  Others


• 変形性股関節症を伴った大腿骨転子部骨折に対する治療方針の検討

  山崎善功, 木嶋雄介, 熊谷宏, 織邊隆, 西山隆之

  79歳女。23歳時に左大腿骨外反骨切り術、45歳時に右人工股関節全置換術を施行されていた。術前歩行能力は一本杖歩行で自立しており、左股関節痛はなかった。今回、転倒して受傷し、近医にて大腿骨転子部骨折と診断され当院紹介となった。単純レントゲンにて左大腿骨転子部骨折(AO分類31 A2-2)を認め、更に左股関節は進行期の股関節OAを呈していた。左大腿骨頸部は高度外反を呈していた。骨接合術を行い、術後2週で歩行器歩行可能、術後10週で一本杖歩行可能となり、術後12週時に股JOA score 58点で自宅退院となった。

  中部日本整形外科災害外科学会, 2017, 中部日本整形外科災害外科学会雑誌, 60(4) (4), 713 - 714, Japanese

  [Refereed]

  Others


• 高齢者寛骨臼骨折に対し一期的THAを施行した2例

  西山隆之, 織邊隆, 熊谷宏, 木嶋雄介, 山崎善功

  症例1は83歳女で、ベッドから転落して受傷した。受傷から11日目の単純X線・CTにて左寛骨臼荷重部の高度圧潰と骨頭骨折、後柱骨折、後壁の粉砕骨折を認め、股関節JOAスコアは28点であった。受傷から24日目に骨欠損部に塊状同種骨移植と自家骨頭を充填し、KT plateを用いて左寛骨臼を再建し、左大腿骨側はExeter stemを用いて一期的人工股関節全置換術を行った。術後12ヵ月でJOAスコアは52点であった。症例2は84歳女で、人工骨頭置換術の既往があった。転倒受傷から1ヵ月後の単純X線・CTにて人工骨頭が臼底に突出し、左寛骨臼はT字状骨折を認め、JOAスコアは39点であった。受傷から2ヵ月後に、症例1と同様に塊状同種骨移植と左寛骨臼を再建したが、術後ステムが徐々に沈下しゆるみを認めたため5週後にExeter long stemを用いて再置換術を行った。術後3年7ヵ月でJOAスコアは73点であった。

  中部日本整形外科災害外科学会, 2017, 中部日本整形外科災害外科学会雑誌, 60(4) (4), 783 - 784, Japanese

  [Refereed]

  Others


• 持続洗浄と陰圧閉鎖療法を併用して治療した化膿性膝関節炎・大腿部ガス壊疽の1例

  山下貴大, 大江啓介, 櫻井敦志, 澤村悟

  60歳男。転倒して左膝を打撲し、腫脹、疼痛を認めたため受傷1週後に近医にて関節穿刺を施行された。その1週間後に腫脹が増強し、関節液からGBSが検出され、翌日に関節鏡視下滑膜切除術を施行された。術後3日目に著明な炎症所見の増悪を認め当院紹介となり、来院時のCTで大腿部ガス壊疽が疑われたため、膝関節に関しては関節鏡視下滑膜切除術を、大腿部は内側前面を約30cmにわたり皮切をおいて病巣掻爬術を施行した。フォローの造影CTにて膝蓋骨にも膿瘍を疑う所見を認めたため膝蓋骨も切除し、創管理、肉芽形成促進目的に陰圧閉鎖療法(NPWT)を開始した。しかし、感染が制御できず、再度開放創での管理に切り替えるも効果なく、持続洗浄とNPWTの併用を開始した。その結果、良好な肉芽形成、炎症所見の改善が得られ、創部も縫縮していったが、膝関節周囲のみ皮膚が退縮して縫縮困難となり、初回手術から2ヵ月経過時点で形成外科にて広背筋皮弁を用いた遊離皮弁術を施行した。術後経過は良好で、最終手術から3ヵ月後には膝関節を80度程度まで屈曲可能となり、杖歩行も可能となった。

  中部日本整形外科災害外科学会, 2017, 中部日本整形外科災害外科学会雑誌, 60(5号) (5号), 907 - 908, Japanese

  [Refereed]

  Others


• 高齢者の寛骨臼骨折に対し,一期的にTHAを施行した2例

  大江啓介, 西山隆之, 織邊隆, 熊谷宏, 木嶋雄介, 山崎善功

  2017, 中部日本整形外科災害外科学会雑誌, 60


• 変形性股関節症を伴った大腿骨転子部骨折に対する治療方針の検討

  山崎善功, 大江啓介, 木嶋雄介, 熊谷宏, 織邊隆, 西山隆之

  2017, 中部日本整形外科災害外科学会雑誌, 60


• 炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる-臨床試験の報告-

  新倉隆宏, 岩倉崇, 李相亮, 大江啓介, 福井友章, 酒井良忠, 黒田良祐

  2017, 骨折, 39(Supplement) (Supplement)


• 高齢者のBHA,THA後の寛骨臼骨折の治療について

  大江啓介, 西山隆之, 織邊隆, 山崎善功, 櫻井敦志

  2017, 骨折, 39(Supplement) (Supplement)


• 人工骨頭置換術におけるJ-Taperステムの初期固定性について

  山崎善功, 西山隆之, 織邊隆, 齋藤寧彦, 熊谷宏, 大江啓介, 奥町悦子, 木嶋雄介

  2017, 日本人工関節学会プログラム・抄録集, 47th


• CO₂経皮吸収はラット骨欠損モデルにおいて骨形成を促進させる

  小田崇弘, 黒岩祐, 高原俊介, 新倉路生, 隈部洋平, 李相亮, 大江啓介, 岩倉崇, 福井友章, 酒井良忠, 新倉隆宏, 黒田良祐

  2017, 移植(Web), 52(6) (6), 581(J‐STAGE), Japanese


• 変形性股関節症を伴った大腿骨転子部骨折に対する治療方針の検討

  山崎 善功, 大江 啓介, 木嶋 雄介, 熊谷 宏, 織邊 隆, 西山 隆之

  中部日本整形外科災害外科学会, 2017, 中部日本整形外科災害外科学会雑誌, 60(春季学会) (春季学会), 80 - 80, Japanese


• 高齢者の寛骨臼骨折に対し、一期的にTHAを施行した2例

  大江 啓介, 西山 隆之, 織邊 隆, 熊谷 宏, 木嶋 雄介, 山崎 善功

  中部日本整形外科災害外科学会, 2017, 中部日本整形外科災害外科学会雑誌, 60(春季学会) (春季学会), 115 - 115, Japanese


• 持続洗浄と陰圧閉鎖療法を併用して治療した化膿性膝関節炎・大腿部ガス壊疽の1例

  山下 貴大, 大江 啓介, 櫻井 敦志, 藤田 寛則, 岩倉 崇, 澤村 悟

  中部日本整形外科災害外科学会, 2017, 中部日本整形外科災害外科学会雑誌, 60(5) (5), 160 - 160, Japanese


• 炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる 臨床試験の報告

  新倉 隆宏, 岩倉 崇, 李 相亮, 大江 啓介, 福井 友章, 酒井 良忠, 黒田 良祐

  (一社)日本骨折治療学会, 2017, 骨折, 39(Suppl.) (Suppl.), S74 - S74, Japanese


• 偽関節手術後に低出力超音波パルスを使用した症例についての検討

  李 相亮, 新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, 2017, 骨折, 39(Supplement) (Supplement), S295 - S295, Japanese


• 高齢者のBHA、THA後の寛骨臼骨折の治療について

  大江 啓介, 西山 隆之, 織邊 隆, 山崎 善功, 櫻井 敦志

  (一社)日本骨折治療学会, 2017, 骨折, 39(Suppl.) (Suppl.), S410 - S410, Japanese


• 骨再生と骨癒合促進 CO2経皮吸収はラット骨欠損モデルにおける骨形成を促進させる

  黒岩 祐, 新倉 隆宏, 高原 俊介, 李 相亮, 大江 啓介, 岩倉 崇, 福井 友章, 新倉 路生, 隈部 洋平, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, 2017, 日本整形外科学会雑誌, 91(8) (8), S1481 - S1481, Japanese


• 炭酸ガス経皮吸収は骨折後の筋萎縮を軽減する

  井上 美帆, 酒井 良忠, 上羽 岳志, 大江 啓介, 西本 華子, 古賀 敬章, 赤羽 志保, 李 相亮, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, 2017, 日本整形外科学会雑誌, 91(8) (8), S1555 - S1555, Japanese


• 骨折治癒過程におけるmicroRNAの発現 糖尿病・健常ラット間の比較検討

  高原 俊介, 李 相亮, 新倉 隆宏, 大江 啓介, 福井 友章, 新倉 路生, 黒岩 祐, 隈部 洋平, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, 2017, 日本整形外科学会雑誌, 91(8) (8), S1640 - S1640, Japanese


• 骨形成不全症に合併した上腕骨骨幹部偽関節に対して下顎骨用locking plateを用いて治療した1例

  佐野 翔平, 新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  中部日本整形外科災害外科学会, 2017, 中部日本整形外科災害外科学会雑誌, 60(秋季学会) (秋季学会), 193 - 193, Japanese


• 大腿骨近位部骨折を起こした高齢者におけるビタミンD充足度の調査

  新倉 隆宏, 大江 啓介, 岩倉 崇, 李 相亮, 福井 友章, 櫻井 敦志, 酒井 良忠, 黒田 良祐

  (一社)日本骨粗鬆症学会, 2017, 日本骨粗鬆症学会雑誌, 3(Suppl.1) (Suppl.1), 283 - 283, Japanese


• 人工骨頭置換術におけるJ-Taperステムの初期固定性について

  山崎 善功, 西山 隆之, 織邊 隆, 齋藤 寧彦, 熊谷 宏, 大江 啓介, 奥町 悦子, 木嶋 雄介

  Tapered Wedge製ステムであるJ-Taperステムによる人工骨頭置換術(BHA)の短期成績を報告した。当院でBHAを行い、術後3ヵ月以上経過観察が可能であった24例24股(男性4股、女性20股、平均80.8歳)を対象とした。ステムの沈下量は平均0.93mmで、3mm以上の沈下を生じたのは1股であったが、進行性のものではなかった。ステムの固定性について全股でporous surfaceにradiolucencyを認めず、すべてがbone ingrowthであった。ステム周囲の骨変化について、spot weldsが21股(87.5%)で認められ、zone 1:5股、zone 7:21股であった。stress shieldingが8股(33.3%)で認められ、Enghの分類のI度13股(54.2%)、II度5股(20.8%)、III度6股(25.0%)、IV度0股であった。固定様式と骨変化の出現率について比較したところ、両者間に明らかな関連性は認めなかった。良好な初期固定性が得られ、骨質が不良とされる高齢者においても初期固定性は良好であることが示唆された。

  (一社)日本人工関節学会, 2017, 日本人工関節学会誌, 47, 527 - 528, Japanese


• 大腿骨近位部骨折を起こした高齢者におけるビタミンD充足度の調査

  新倉 隆宏, 大江 啓介, 岩倉 崇, 酒井 良忠, 李 相亮, 櫻井 敦志, 黒坂 昌弘

  (公社)日本整形外科学会, 2016, 日本整形外科学会雑誌, 90(2) (2), S156 - S156, Japanese


• 不安定型骨盤輪骨折における創外固定法の比較(第2報)

  大江 啓介, 長宗 高樹, 新倉 隆宏, 黒田 良祐, 黒坂 昌弘

  日本創外固定・骨延長学会, 2016, 日本創外固定・骨延長学会雑誌, 27, 120 - 120, Japanese


• Mangled foot治療の小経験

  大江 啓介, 櫻井 敦志

  (一社)日本外傷学会, 2016, 日本外傷学会雑誌, 30th(2) (2), 243 - 243, Japanese


• 当科における大腿骨遠位単顆骨折の治療成績

  嶌村 将志, 大江 啓介, 櫻井 敦志, 北野 洋一, 藤田 寛則, 澤村 悟

  (一社)日本骨折治療学会, 2016, 骨折, 38(2) (2), 426 - 428, Japanese


• 大腿骨近位部骨折を起こした高齢者におけるビタミンD充足度の調査

  新倉 隆宏, 大江 啓介, 岩倉 崇, 酒井 良忠, 李 相亮, 櫻井 敦志, 黒田 良祐, 黒坂 昌弘

  (一社)日本骨折治療学会, 2016, 骨折, 38(Supplement) (Supplement), S141 - S141, Japanese


• 足部重症開放骨折に対して足部温存を行った1例

  小田 崇弘, 大江 啓介, 藤田 寛則, 櫻井 敦志, 高島 良典, 吉田 雄介, 澤村 悟

  (一社)日本骨折治療学会, 2016, 骨折, 38(Supplement) (Supplement), S185 - S185, Japanese


• 大腿骨転子部骨折術後合併症例に対する人工骨頭置換術についての検討

  大江 啓介, 櫻井 敦志, 藤田 寛則, 小田 崇弘, 吉田 雄介, 高島 良典, 澤村 悟

  (一社)日本骨折治療学会, 2016, 骨折, 38(Supplement) (Supplement), S229 - S229, Japanese


• Hansson Pinlocによる大腿骨頸部骨折に対して骨接合術の短期成績

  高島 良典, 櫻井 敦志, 小田 崇弘, 吉田 雄介, 藤田 寛則, 大江 啓介, 澤村 悟

  (一社)日本骨折治療学会, 2016, 骨折, 38(Supplement) (Supplement), S237 - S237, Japanese


• 踵骨骨折に合併した腓骨筋腱脱臼の7例

  山下 貴大, 大江 啓介, 櫻井 敦志, 藤田 寛則, 澤村 悟

  中部日本整形外科災害外科学会, 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 296 - 296, Japanese


• 炭酸ガス経皮吸収は大腿骨骨折モデルの筋萎縮を軽減する

  井上 美帆, 酒井 良忠, 上羽 岳志, 大江 啓介, 新倉 隆宏, 李 相亮, 岩倉 崇, 仲山 舞, 原田 理沙, 赤羽 志保, 西本 華子, 黒田 良祐, 黒坂 昌弘

  (公社)日本リハビリテーション医学会, 2016, The Japanese Journal of Rehabilitation Medicine, 53(Supplement) (Supplement), I237 - I237, Japanese


• 骨欠損を伴うMangled foot(Gustilo type3B)の治療経験 足部再建におけるMasquelet法の有用性について

  田村 亮介, 大江 啓介, 寺師 浩人, 前田 翔

  (一社)日本マイクロサージャリー学会, 2016, 日本マイクロサージャリー学会学術集会プログラム・抄録集, 43rd, 183 - 183, Japanese


• 淡路島における大腿骨近位部骨折治療と地域連携の現状と課題

  櫻井 敦志, 大江 啓介, 藤田 寛則, 澤村 悟

  (一社)日本骨粗鬆症学会, 2016, 日本骨粗鬆症学会雑誌, 2(Suppl.1) (Suppl.1), 301 - 301, Japanese


• 骨盤ベルトの大腿骨大転子部周辺における負荷の左右差の評価

  清水祐亮, 長宗高樹, 長宗高樹, 大江啓介, LEE Sangyang, 新倉隆宏, 黒田良祐, 黒坂昌弘

  2015, ファジィシステムシンポジウム講演論文集(CD-ROM), 31st


• 不安定型骨盤輪骨折に対する新しい創外固定方法の検討(第2報)

  大江 啓介, 長宗 高樹, 新倉 隆宏, 黒田 良祐, 黒坂 昌弘

  (一社)日本骨折治療学会, 2015, 骨折, 37(1) (1), 70 - 74, Japanese


• 大腿骨転子部骨折 大腿骨転子部骨折の治療における合併症とその対策

  新倉 隆宏, 李 相亮, 黒坂 昌弘, 正田 悦朗, 櫻井 敦志, 大江 啓介

  (一社)日本骨折治療学会, 2015, 骨折, 37(2) (2), 261 - 264, Japanese


• 大腿骨転子部骨折に対するGamma 3 nailの術後X線学的検討について

  大江 啓介, 櫻井 敦志, 藤田 寛則, 飯田 奈津子, 新倉 路生, 澤村 悟

  (一社)日本骨折治療学会, 2015, 骨折, 37(2) (2), 402 - 405, Japanese


• 多発外傷における整形外科の介入について

  大江 啓介, 櫻井 敦志, 坂平 英樹, 吉田 剛

  (一社)日本外傷学会, 2015, 日本外傷学会雑誌, 29th(2) (2), 222 - 222, Japanese


• 人工股関節ステム周辺大腿骨骨折に対するロッキングプレート固定の治療成績 多施設後ろ向き研究

  岩倉 崇, 新倉 隆宏, 李 相亮, 櫻井 敦志, 大江 啓介, 柴沼 均, 角田 雅也, 圓尾 明弘, 正田 悦朗, 酒井 良忠, 黒坂 昌弘

  (公社)日本整形外科学会, 2015, 日本整形外科学会雑誌, 89(2) (2), S280 - S280, Japanese


• インプラント周囲大腿骨遠位部骨折に対し内側にLCP-PLTを使用した2例

  北野 洋一, 大江 啓介, 櫻井 敦志, 貞光 隆, 嶌村 将史, 藤田 寛則, 澤村 悟

  (一社)日本骨折治療学会, 2015, 骨折, 37(Supplement) (Supplement), S167 - S167, Japanese


• 当院における大腿骨単顆骨折の治療成績

  嶌村 将志, 大江 啓介, 北野 洋一, 藤田 寛則, 櫻井 敦志, 澤村 悟

  (一社)日本骨折治療学会, 2015, 骨折, 37(Supplement) (Supplement), S244 - S244, Japanese


• 大腿骨転子部骨折術後に骨頭下骨折を生じた2例

  大江 啓介, 櫻井 敦志

  症例1は87歳女性で、左大腿骨転子部骨折(Jensen3)に対しガンマ3ネイルを用いて骨接合術を施行した。術後整復位は頸部の回旋転位を認めたが、ラグスクリューの位置はX線上センター/センター(正面像/側面像)でTipApexディスタンス(TAD)は16.2mmと良好であった。術後、順調に経過し、ADLは術前の歩行レベルまで回復していた。術後6ヵ月時に転倒し、左股関節痛が出現し、X線で左骨頭下骨折を認め、人工骨頭置換術となった。骨頭下骨折受傷時のCTで転子部の骨癒合は得られていた。症例2は80歳女性で、左大腿骨転子部骨折(Jensen2)対しガンマ3ネイルを用いて骨接合術を施行した。術後の整復位、ラグスクリューの刺入位置はX線上センター/センターでTADは11.9mmと良好であったが、ネイルのエントリーポイントが梨状窩に近い部位となっていた。術後12ヵ月から誘因なく左股関節痛が出現し、徐々に痛みが増強し、術後13ヵ月の受診時X線で左骨頭下骨折を認め、人工骨頭置換術となった。骨頭下骨折受傷時のCTでは症例1と同様に、転子部の骨癒合は得られていた。また、MRI所見はT1/T2強調像ともに骨頭全体的に輝度の変化を認めた。手術時に提出した骨頭組織の病理所見では骨壊死を認めた。2例とも既往症にステロイド使用歴、アルコール愛飲歴はなかった。

  日本股関節学会, 2015, Hip Joint, 41, 973 - 976, Japanese


• 大腿骨転子部骨折術後に骨頭下骨折を生じた2例

  大江啓介, 櫻井敦志

  2014, 日本股関節学会学術集会プログラム・抄録集, 41st


• 骨盤ベルトの大腿骨大転子部周辺における応力分布計測システムの開発

  清水祐亮, 長宗高樹, 長宗高樹, 大江啓介, LEE Sangyang, 新倉隆宏, 黒田良祐, 黒坂昌弘

  2014, ファジィシステムシンポジウム講演論文集(CD-ROM), 30th


• 膝蓋骨骨折に対するTBW法とひまわり法の術後成績の検討

  高原 俊介, 大江 啓介, 山口 幸之助, 藤田 寛則, 櫻井 敦志, 澤村 悟

  (一社)日本骨折治療学会, 2014, 骨折, 36(1) (1), 130 - 133, Japanese


• 当院におけるガンマ3ネイルのカットアウト症例の検討

  大江 啓介, 櫻井 敦志, 藤田 寛則, 高原 俊介, 山口 幸之助, 澤村 悟

  (一社)日本骨折治療学会, 2014, 骨折, 36(2) (2), 332 - 335, Japanese


• 筋損傷を科学する 炭酸ガス経皮吸収の筋肉への効果

  酒井 良忠, 大江 啓介, 上羽 岳志, 三輪 雅彦, 新倉 隆宏, 李 相亮, 黒田 良祐, 黒坂 昌弘

  (公社)日本整形外科学会, 2014, 日本整形外科学会雑誌, 88(1) (1), 34 - 39, Japanese


• 大腿骨転子部骨折に対するGamma 3 nailの術後X線学的検討について

  大江 啓介, 櫻井 敦志, 藤田 寛則, 新倉 路生, 飯田 奈津子, 澤村 悟

  (公社)日本整形外科学会, 2014, 日本整形外科学会雑誌, 88(3) (3), S569 - S569, Japanese


• 大腿骨近位部骨折手術後の血清プレアルブミン値は、急性期病院転院時、回復期病院退院時のADLと相関する

  大江 啓介, 酒井 良忠, 新倉 隆宏, 黒坂 昌弘

  (公社)日本リハビリテーション医学会, 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S267 - S267, Japanese


• 転子部骨折 大腿骨転子部骨折の治療における合併症とその対策

  新倉 隆宏, 正田 悦朗, 櫻井 敦志, 大江 啓介, 北田 真平, 李 相亮, 岩倉 崇, 黒坂 昌弘

  (一社)日本骨折治療学会, 2014, 骨折, 36(Supplement) (Supplement), S26 - S27, Japanese


• 大腿骨転子部骨折に対するGamma 3 nailの術後X線学的検討について

  大江 啓介, 櫻井 敦志, 藤田 寛則, 新倉 路生, 飯田 奈津子, 澤村 悟

  (一社)日本骨折治療学会, 2014, 骨折, 36(Supplement) (Supplement), S112 - S112, Japanese


• 不安定型骨盤輪骨折に対する新しい創外固定法の検討(第2報)

  大江 啓介, 長宗 高樹, 新倉 隆宏, 李 相亮, 黒田 良祐, 黒坂 昌弘

  (一社)日本骨折治療学会, 2014, 骨折, 36(Supplement) (Supplement), S145 - S145, Japanese


• 足関節外果剥離骨折を伴う腓骨筋腱脱臼を合併した距骨外側突起骨折の一例

  飯田 奈津子, 櫻井 敦志, 大江 啓介, 藤田 寛則, 新倉 路生, 澤村 悟

  (一社)日本骨折治療学会, 2014, 骨折, 36(Supplement) (Supplement), S287 - S287, Japanese


• 大腿骨転子部骨折に対するGamma 3 nailの術後X線学的検討について

  大江 啓介, 櫻井 敦志

  Gamma 3 nailを用いて骨接合術を行い、3ヵ月以上経過観察可能であった大腿骨転子部骨折206例を対象に、X線像を用いて術後のスライディング量を骨折型、術後整復位、tip apex distance、ラグスクリューの位置により評価した。その結果、ラグスクリューのスライディング量は術後整復位と関係している可能性が高く、特に側面像で髄内型の症例において有意に多いことが判明した。適切な術後整復位、適切なラグスクリューの骨頭内挿入深度・位置とすることで過度のスライディングを防ぐことができる可能性が示唆された。

  日本股関節学会, 2014, Hip Joint, 40, 394 - 398, Japanese


• 大腿骨転子部骨折に対するGamma 3 nailの術後X線学的検討について

  大江啓介, 櫻井敦志

  2013, 日本股関節学会学術集会プログラム・抄録集, 40th


• 不安定型骨盤輪骨折に対する新しい創外固定法の検討

  大江 啓介, 長宗 高樹, 新倉 隆宏, 李 相亮, 黒田 良祐, 黒坂 昌弘

  日本創外固定・骨延長学会, 2013, 日本創外固定・骨延長学会雑誌, 24, 158 - 158, Japanese


• The Effect of Transcutaneous Carbon Dioxide (CO₂) Application after Endurance Exercise in Rats

  大江啓介, 酒井良忠, 上羽岳志, 新倉隆宏, 三輪雅彦, 黒坂昌弘

  (公社)日本リハビリテーション医学会, 2013, Japanese Journal of Rehabilitation Medicine, 50(3) (3), 195 - 201, Japanese


• 炭酸ガス経皮吸収は骨折治癒促進法となりうる

  古賀 敬章, 新倉 隆宏, 李 相亮, 堂垣 佳宏, 奥町 悦子, 上羽 岳志, 酒井 良忠, 大江 啓介, 黒田 良祐, 三輪 雅彦, 黒坂 昌弘

  (公社)日本整形外科学会, 2013, 日本整形外科学会雑誌, 87(2) (2), S291 - S291, Japanese


• 大腿骨転子部骨折術後における移動状態、ADLの予後予測因子の検討

  大江 啓介, 黒坂 昌弘, 酒井 良忠

  (公社)日本リハビリテーション医学会, 2013, The Japanese Journal of Rehabilitation Medicine, 50(Suppl.) (Suppl.), S188 - S188, Japanese


• 経皮的炭酸ガス治療の筋肉量、脂肪量に対する影響

  酒井 良忠, 大江 啓介, 上羽 岳志, 李 相亮, 新倉 隆宏, 三輪 雅彦, 黒坂 昌弘

  (公社)日本リハビリテーション医学会, 2013, The Japanese Journal of Rehabilitation Medicine, 50(Suppl.) (Suppl.), S232 - S232, Japanese


• 当院におけるガンマ3ネイルのカットアウト症例の検討

  大江 啓介, 櫻井 敦志, 藤田 寛則, 高原 俊介, 山口 幸之助, 澤村 悟

  (一社)日本骨折治療学会, 2013, 骨折, 35(Supplement) (Supplement), S77 - S77, Japanese


• 膝蓋骨骨折に対するひまわり法とTBW法の術後成績の検討

  高原 俊介, 大江 啓介, 山口 幸之助, 藤田 寛則, 櫻井 敦志, 澤村 悟

  (一社)日本骨折治療学会, 2013, 骨折, 35(Supplement) (Supplement), S316 - S316, Japanese


• 尺骨鉤状突起骨折を伴う肘関節脱臼骨折の4症例

  櫻井 敦志, 大江 啓介, 藤田 寛則, 西村 秀樹, 畠山 拓也, 澤村 悟

  (一社)日本骨折治療学会, 2013, 骨折, 35(3) (3), 550 - 553, Japanese


• 炭酸ガス経皮吸収が運動後のラットの筋肉に及ぼす影響について

  大江 啓介, 酒井 良忠, 上羽 岳志, 新倉 隆宏, 李 相亮, 田中 雅也, 三輪 雅彦, 黒坂 昌弘

  (公社)日本リハビリテーション医学会, 2012, The Japanese Journal of Rehabilitation Medicine, 49(Suppl.) (Suppl.), S267 - S267, Japanese


• 骨折時の筋萎縮に対する、炭酸ガス治療の効果

  酒井 良忠, 大江 啓介, 上羽 岳志, 新倉 隆宏, 李 相亮, 田中 雅也, 三輪 雅彦, 黒坂 昌弘

  (公社)日本リハビリテーション医学会, 2012, The Japanese Journal of Rehabilitation Medicine, 49(Suppl.) (Suppl.), S267 - S267, Japanese


• 【難治性骨折に対する治療】 難治性骨折の治療(総論) 低出力超音波パルス(LIPUS) ヒト骨折血腫由来細胞およびヒト偽関節組織由来細胞を用いた低出力超音波パルスの作用機序の生物学的検討

  新倉 隆宏, 李 相亮, 大江 啓介, 岩倉 崇, 古賀 敬章, 堂垣 佳宏, 奥町 悦子, 黒坂 昌弘

  骨折血腫細胞および偽関節細胞を6-well plateに播種し、低出力超音波パルス(LIPUS)照射群と非照射で比較・検討した。その結果、LIPUS照射は骨折血腫細胞の増殖には影響しなかったが、骨分化に関わるアルカリホスファターゼ(ALP)活性、オステオカルシン分泌量、アリザリンレッド染色、骨分化関連マーカーの遺伝子発現、Runx 2、osterixの発現においては増強した。一方、LIPUS照射は偽関節細胞の増殖にも影響しなかったが、骨分化能に関してはLIPUS照射の有無で有意差は認めなかった。次に骨形成因子(BMP-7)存在下でも同様の検討したところ、LIPUS照射による骨折血腫細胞の増殖能に対する影響はなかったが、骨分化に関わるALP活性、ALP、Runx 2、オステオポンチン、オステオカルシンのmRNA発現、アリザリンレッド染色においてBMP-7投与とLIPUS照射を同時に行った群で増強していた。また、偽関節細胞の増殖能に対してもLIPUS照射による影響はなかったが、ALP活性、ALP、Runx 2のmRNA発現、アリザリンレッド染色においてBMP-7投与とLIPUS照射を同時に行うことで増強していた。

  (株)南江堂, 2012, 別冊整形外科, (61) (61), 52 - 56, Japanese


• 筋損傷を科学する 炭酸ガス経皮吸収の筋肉への効果

  酒井 良忠, 大江 啓介, 三輪 雅彦, 上羽 岳志, 新倉 隆宏, 李 相亮, 黒田 良祐, 黒坂 昌弘

  (公社)日本整形外科学会, 2012, 日本整形外科学会雑誌, 86(8) (8), S1225 - S1225, Japanese


• 炭酸ガス経皮吸収はラットの骨折治癒を促進する

  古賀 敬章, 新倉 隆宏, 李 相亮, 堂垣 佳宏, 奥町 悦子, 上羽 岳志, 酒井 良忠, 大江 啓介, 黒田 良祐, 三輪 雅彦, 黒坂 昌弘

  (公社)日本整形外科学会, 2012, 日本整形外科学会雑誌, 86(8) (8), S1232 - S1232, Japanese


• 炭酸ガス経皮吸収が運動後のラットの筋肉に及ぼす影響について

  大江 啓介, 酒井 良忠, 新倉 隆宏, 李 相亮, 古賀 敬章, 堂垣 佳宏, 上羽 岳志, 田中 雅也, 三輪 雅彦, 黒田 良祐, 黒坂 昌弘

  (公社)日本整形外科学会, 2012, 日本整形外科学会雑誌, 86(8) (8), S1268 - S1268, Japanese


• A case of anterior fusion for Levine type II Hangman’s fracture

  畠山拓也, 大江啓介, 藤田寛則, 西村英樹, 櫻井敦志, 澤村悟

  84歳女性。階段から転落受傷し、後頸部痛を主訴に著者らの施設へ救急搬送とされた。単純X線、CT、MRI所見よりLevine分類type IIのHangman骨折と診断され、C2/3頸椎前方固定術が施行された。その結果、術後6ヵ月の最終調査時には1本杖歩行が可能で、筋力は右三角筋と右手指の屈曲・伸展・外転はMMT4であったが、これら以外は5であった。尚、単純X線では矯正損失はなく、骨癒合も得られていた。

  中部日本整形外科災害外科学会, 2012, 中部日本整形外科災害外科学会雑誌, 55(3) (3), 655 - 656, Japanese


• 不安定型骨盤輪骨折に対する新しい創外固定方法の検討(第1報)

  大江 啓介, 長宗 高樹, 新倉 隆宏, 李 相亮, 黒田 良祐, 黒坂 昌弘

  (一社)日本骨折治療学会, 2012, 骨折, 34(3) (3), 536 - 538, Japanese


• 尺骨鉤状突起骨折を伴う肘関節脱臼骨折の4症例

  櫻井 敦志, 大江 啓介, 藤田 寛則, 西村 英樹, 畠山 拓也, 澤村 悟

  (一社)日本骨折治療学会, 2012, 骨折, 34(Supplement) (Supplement), S200 - S200, Japanese


• 当科における大腿骨転子下骨折の治療成績

  西村 英樹, 桜井 敦志, 大江 啓介, 藤田 寛則, 畠山 拓也, 澤村 悟

  (一社)日本骨折治療学会, 2012, 骨折, 34(Supplement) (Supplement), S254 - S254, Japanese


• 大腿骨転子部骨折における急性期病院在院日数、総在院日数に影響する因子の検討

  大江 啓介, 藤田 寛則, 西村 英樹, 畠山 拓也, 櫻井 敦志, 澤村 悟, 酒井 良忠

  (一社)日本骨折治療学会, 2012, 骨折, 34(Supplement) (Supplement), S282 - S282, Japanese


• Hangman骨折に対して前方固定術を施行した1例

  畠山拓也, 大江啓介, 藤田寛則, 西村英樹, 櫻井敦志, 澤村悟

  2011, 中部日本整形外科災害外科学会雑誌, 54


• 骨盤・下肢骨折における静脈血栓塞栓症の発生状況

  新倉 隆宏, 李 相亮, 大江 啓介, 康 暁博, 古賀 敬章, 堂垣 佳宏, 黒坂 昌弘

  (公社)日本整形外科学会, 2011, 日本整形外科学会雑誌, 85(2) (2), S144 - S144, Japanese


• Trauma Center Murnauにおける鎖骨近位端骨折の観血的治療法について

  大江 啓介, 新倉 隆宏, 李 相亮, 康 暁博, 古賀 敬章, 堂垣 佳宏, 三輪 雅彦, 黒坂 昌弘, Hierholzer Christian, Buehren Volker

  (公社)日本整形外科学会, 2011, 日本整形外科学会雑誌, 85(3) (3), S630 - S630, Japanese


• 下肢外傷後軟部組織欠損に対する陰圧閉鎖療法用機器の使用経験

  中野 直樹, 新倉 隆宏, 大江 啓介, 李 相亮, 池川 卓哉, 黒坂 昌弘

  陰圧閉鎖療法(NPWT)用機器(VACシステム)を用い、外傷後に下肢軟部組織欠損を生じた2症例の臨床像について検討した。症例1は45歳男性で、pilon骨折に対するプレート固定術後に創治癒が遷延し、プレート・脛骨が露出した。症例2は37歳男性で、Lisfranc関節脱臼骨折に対する経皮ピンニング後、術前からの足背部の皮膚壊死が潰瘍化して深いポケットを形成した。いずれも外用療法では治癒傾向がみられず、VACシステムを用いたNPWTを行い、NPWT開始から22〜26日に創部の肉芽形成を得た。この治療法は整形外科関連の軟部組織欠損症例に対し、従来の治療法の代替手段として有力な治療選択肢の1つになると考えられた。

  金原出版(株), 2011, 整形・災害外科, 54(8) (8), 983 - 986, Japanese


• ロッキングプレートを用いた偽関節・遷延治癒骨折手術の治療成績

  新倉 隆宏, 李 相亮, 大江 啓介, 康 暁博, 古賀 敬章, 黒坂 昌弘

  (一社)日本骨折治療学会, 2011, 骨折, 33(2) (2), 515 - 519, Japanese


• Demonstration of Bohr effect using transcutaneous CO₂ application device in vivo

  大江啓介, 三輪雅彦, 新倉隆宏, 李相亮, 黒坂昌弘, 酒井良忠

  炭酸ガス治療器を用いて、炭酸ガス経皮吸収による生体内でのボーア効果を証明した。健常成人男性7名を(平均年齢32歳)対象に、一側前腕屈側に近赤外線分光装置プローブを装着し、酸化型と還元型ヘモグロビン濃度を測定した。測定方法として、初めの10分間は駆血のみで測定し、その後の10分間は駆血したままで経皮吸収促進剤を塗布して炭酸ガスを送気し、測定した(炭酸ガス群)。対照は対側上肢で同様に測定し炭酸ガスの代わりに空気を送気した(対照群)。駆血後から両群とも速やかに酸化型ヘモグロビンの減少、還元型ヘモグロビンの増加を認めた。炭酸ガス群は送気後4分以降で有意に酸化型ヘモグロビンの減少を認め、還元型ヘモグロビンは2分以降から有意に増加した。これらの変化をHill式から数学的にシミュレートし、グラフ化すると、炭酸ガス経皮吸収によって酸素解離曲線が右方向に移動し、生体内でボーア効果が生じたことを示唆していると考えられた。

  中部日本整形外科災害外科学会, 2011, 中部日本整形外科災害外科学会雑誌, 54(3) (3), 445 - 446, Japanese


• 非運動下における炭酸ガス経皮吸収がラットの前脛骨筋に及ぼす効果について

  大江 啓介, 李 相亮, 酒井 良忠, 新倉 隆宏, 康 暁博, 古賀 敬章, 堂垣 佳宏, 上羽 岳志, 田中 雅也, 三輪 雅彦, 黒坂 昌弘

  (公社)日本整形外科学会, 2011, 日本整形外科学会雑誌, 85(8) (8), S1120 - S1120, Japanese


• 炭酸ガス経皮投与のヒトにおける筋疲労回復に関する検討

  酒井 良忠, 大江 啓介, 李 相亮, 新倉 隆宏, 康 暁博, 古賀 敬章, 上羽 岳志, 三輪 雅彦, 黒坂 昌弘

  (公社)日本整形外科学会, 2011, 日本整形外科学会雑誌, 85(8) (8), S1120 - S1120, Japanese


• 運動器の再生 末梢血細胞を用いた骨・血管再生療法による偽関節治療

  松本 知之, 新倉 隆宏, 福井 友章, 美舩 泰, 川上 洋平, 三輪 雅彦, 李 相亮, 大江 啓介, 川本 篤彦, 黒坂 昌弘, 浅原 孝之, 黒田 良祐

  (公社)日本整形外科学会, 2011, 日本整形外科学会雑誌, 85(8) (8), S1182 - S1182, Japanese


• 炭酸ガス経皮投与はラットの運動パフォーマンスを向上させる

  李 相亮, 大江 啓介, 酒井 良忠, 新倉 隆宏, 康 暁博, 上羽 岳志, 田中 雅也, 三輪 雅彦, 黒坂 昌弘

  (公社)日本整形外科学会, 2011, 日本整形外科学会雑誌, 85(8) (8), S1209 - S1209, Japanese


• 不安定型骨盤輪骨折に対する新しい創外固定法の検討

  大江 啓介, 長宗 高樹, 新倉 隆宏, 李 相亮, 康 暁博, 古賀 敬章, 堂垣 佳宏, 黒田 良祐, 黒坂 昌弘

  (一社)日本骨折治療学会, 2011, 骨折, 33(Supplement) (Supplement), S96 - S96, Japanese


• 経皮炭酸ガス吸収のヒトにおける筋疲労回復、筋増強のメカニズムの解析 筋肉内pHとATP変化の検討

  酒井 良忠, 三輪 雅彦, 大江 啓介, 上羽 岳志, 李 相亮, 黒坂 昌弘

  (公社)日本リハビリテーション医学会, 2011, The Japanese Journal of Rehabilitation Medicine, 48(Suppl.) (Suppl.), S234 - S234, Japanese


• Hangman骨折に対して前方固定術を施行した1例

  畠山 拓也, 大江 啓介, 藤田 寛則, 西村 英樹, 櫻井 敦志, 澤村 悟

  中部日本整形外科災害外科学会, 2011, 中部日本整形外科災害外科学会雑誌, 54(秋季学会) (秋季学会), 229 - 229, Japanese


• 股関節ブロックを併用した大腿骨頸部骨折に対する局所麻酔下骨接合術

  乾 淳幸, 高橋 完靖, 新倉 隆宏, 李 相亮, 大江 啓介, 黒坂 昌弘

  (一社)日本骨折治療学会, 2011, 骨折, 33(4) (4), 889 - 891, Japanese


• 右腸骨に発症し急性虫垂炎様の症状を呈した急性化膿性骨髄炎の1例

  石森 真吾, 大坪 裕美, 下竹 敦哉, 久保川 育子, 森 健, 早川 晶, 竹島 泰弘, 松尾 雅文, 大江 啓介

  (公社)日本小児科学会, Dec. 2010, 日本小児科学会雑誌, 114(12) (12), 1947 - 1948, Japanese


• 基礎研究をもとにした骨折治療の新しい流れ 末梢血CD34陽性細胞による骨・血管再生療法

  松本 知之, 美舩 泰, 福井 友章, 川上 洋平, 三輪 雅彦, 新倉 隆宏, 李 相亮, 大江 啓介, 庄司 太郎, 黒田 知也, 川本 篤彦, 浅原 孝之, 黒坂 昌弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1109 - S1109, Japanese


• 末梢血CD34陽性細胞による骨・血管再生療法

  松本知之, 美舩泰, 美舩泰, 福井友章, 福井友章, 川上洋平, 川上洋平, 三輪雅彦, 新倉隆宏, 李相亮, 大江啓介, 庄司太郎, 庄司太郎, 黒田知也, 黒田知也, 川本篤彦, 浅原孝之, 黒坂昌弘, 黒田良祐

  2010, 日本整形外科学会雑誌, 84(8) (8)


• ロッキングプレートを用いた偽関節・遷延治癒骨折手術の治療成績

  新倉隆宏, 李相亮, 大江啓介, 三輪雅彦, 藤岡宏幸, 牧野健, 名倉一成, 康暁博, 古賀敬章, 黒坂昌弘

  2010, 骨折, 32(Supplement) (Supplement)


• 人工培養骨内細胞のソフトコンピューティングによる評価システム

  八木直美, 大城宜哲, 石川治, 大江啓介, 畑豊

  2010, インテリジェント・システム・シンポジウム(CD-ROM), 20th


• 末梢血CD34陽性細胞との共培養による骨折部血腫由来細胞の早期骨分化促進の検討

  康暁博, 李相亮, 三輪雅彦, 新倉隆宏, 古賀敬章, 松本知之, 大江啓介, 福井友章, 黒田良祐, 黒坂昌弘

  2010, 再生医療, 9, 297, Japanese


• 炭酸ガス経皮吸収によるラットの運動パフォーマンスへの効果

  大江 啓介, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 李 相亮, 上羽 岳志, 田中 雅也, 黒坂 昌弘

  (公社)日本リハビリテーション医学会, 2010, The Japanese Journal of Rehabilitation Medicine, 47(Suppl.) (Suppl.), S157 - S157, Japanese


• 経皮炭酸ガス吸収による筋疲労、筋力増強に関する検討

  酒井 良忠, 三輪 雅彦, 上羽 岳志, 大江 啓介, 李 相亮, 新倉 隆宏, 田中 雅也, 黒坂 昌弘

  (公社)日本リハビリテーション医学会, 2010, The Japanese Journal of Rehabilitation Medicine, 47(Suppl.) (Suppl.), S316 - S316, Japanese


• 偽関節・遷延癒合の成因、治療成績と今後の課題

  新倉 隆宏, 李 相亮, 大江 啓介, 康 暁博, 古賀 敬章, 黒坂 昌弘

  (公社)日本整形外科学会, 2010, 日本整形外科学会雑誌, 84(4) (4), S462 - S462, Japanese


• Locking plateの適応と限界 ロッキングプレートを用いた偽関節・遷延治癒骨折手術の治療成績

  新倉 隆宏, 李 相亮, 大江 啓介, 三輪 雅彦, 藤岡 宏幸, 牧野 健, 名倉 一成, 康 暁博, 古賀 敬章, 黒坂 昌弘

  (一社)日本骨折治療学会, 2010, 骨折, 32(Supplement) (Supplement), S12 - S12, Japanese


• 大腿骨遠位部以遠の下肢骨折における静脈血栓塞栓症の診断状況

  新倉 隆宏, 大江 啓介, 李 相亮, 三輪 雅彦, 康 暁博, 古賀 敬章, 黒坂 昌弘

  (一社)日本骨折治療学会, 2010, 骨折, 32(Supplement) (Supplement), S123 - S123, Japanese


• ヒトの骨折血腫には多分化能を有する未分化細胞が存在する

  大江 啓介, 新倉 隆宏, 李 相亮, 岩倉 崇, 康 暁博, 古賀 敬章, 三輪 雅彦, 黒坂 昌弘

  (一社)日本骨折治療学会, 2010, 骨折, 32(Supplement) (Supplement), S246 - S246, Japanese


• 高齢者大腿骨頸部骨折に対し、股関節ブロックおよび局所麻酔にて骨接合術を施行した症例の検討

  乾 淳幸, 高橋 完靖, 三輪 雅彦, 新倉 隆宏, 李 相亮, 大江 啓介, 黒坂 昌弘

  (一社)日本骨折治療学会, 2010, 骨折, 32(Supplement) (Supplement), S250 - S250, Japanese


• 骨移植と仙腸関節スクリューおよび創外固定にて治療した不安定型骨盤輪骨折後偽関節の1例

  李 相亮, 新倉 隆宏, 大江 啓介, 三輪 雅彦, 康 暁博, 古賀 敬章, 黒坂 昌弘

  (一社)日本骨折治療学会, 2010, 骨折, 32(Supplement) (Supplement), S255 - S255, Japanese


• 低出力超音波パルスはBMP-7によるヒト骨折血腫由来細胞の骨分化を促進する

  李 相亮, 新倉 隆宏, 康 暁博, 古賀 敬章, 大江 啓介, 三輪 雅彦, 黒田 良祐, 黒坂 昌弘

  (公社)日本整形外科学会, 2010, 日本整形外科学会雑誌, 84(8) (8), S1119 - S1119, Japanese


• 炭酸ガス経皮吸収によるラットの下肢筋肉変化について

  大江 啓介, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 李 相亮, 康 暁博, 古賀 敬章, 上羽 岳志, 田中 雅也, 黒坂 昌弘

  (公社)日本整形外科学会, 2010, 日本整形外科学会雑誌, 84(8) (8), S1224 - S1224, Japanese


• ラット骨折モデルでの治癒群と偽関節群とにおけるIGFs/IGFBPsの遺伝子発現差異の検討

  康 暁博, 新倉 隆宏, 李 相亮, 大江 啓介, 古賀 敬章, 三輪 雅彦, 黒坂 昌弘

  (公社)日本整形外科学会, 2010, 日本整形外科学会雑誌, 84(8) (8), S1338 - S1338, Japanese


• 炭酸ガス経皮吸収によるBohr効果の証明 経皮炭酸ガス治療器を用いて

  大江 啓介, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 李 相亮, 黒坂 昌弘

  中部日本整形外科災害外科学会, 2010, 中部日本整形外科災害外科学会雑誌, 53(秋季学会) (秋季学会), 185 - 185, Japanese


• 骨盤骨折と大腿骨骨折における静脈血栓塞栓症の診断

  新倉 隆宏, 三輪 雅彦, 李 相亮, 大江 啓介, 岩倉 崇, 黒坂 昌弘

  骨盤骨折と大腿骨骨折の計105例(男性44例、女性61例・平均61.3歳)を対象に、静脈血栓塞栓症(VTE)の診断状況を調査した。内訳は骨盤骨折単独25例、大腿骨骨折単独61例、多発骨折19例であった。VTE予防法は弾性ストッキング着用と間欠的空気圧迫法を受傷後早期より行い、スクリーニングとして血清D-dimer値測定、画像検査を行った。105例中16例(15.2%)がVTEと診断され、肺血栓塞栓症(PTE)は5例(4.8%)で全例無症候性、近位型の深部静脈血栓症(DVT)は7例、遠位型のDVTは6例であった。VTEの診断率は骨盤骨折16%、大腿骨近位部骨折8%、同骨幹部骨折33.3%、多発骨折26.3%であった。PTEの診断率は骨盤骨折で12%と高率であった。VTEの診断時期は受傷後平均12日であり、16例中13例が15日以内であった。

  (一社)日本骨折治療学会, 2010, 骨折, 32(3) (3), 512 - 517, Japanese


• 炭酸ガス経皮吸収によるラットの運動パフォーマンスへの影響

  大江 啓介, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 李 相亮, 康 暁博, 黒坂 昌弘, 上羽 岳志, 田中 雅也

  (一社)日本臨床スポーツ医学会, 2010, 日本臨床スポーツ医学会誌, 18(4) (4), S130 - S130, Japanese


• 下肢外傷後軟部組織欠損に対するV.A.C.ATS治療システムの使用経験

  中野 直樹, 新倉 隆宏, 大江 啓介, 李 相亮, 池川 卓哉, 黒坂 昌弘

  中部日本整形外科災害外科学会, 2010, 中部日本整形外科災害外科学会雑誌, 53(6) (6), 1433 - 1433, Japanese


• 炭酸ガス経皮吸収は骨格筋の有酸素系代謝を向上させる

  上羽 岳志, 大江 啓介, 三輪 雅彦, 康 暁博, 酒井 良忠, 須賀原 智子, 堂垣 佳宏, 古賀 敬章, 李 相亮, 新倉 隆宏, 黒坂 昌弘

  (公社)日本生化学会, 2010, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回, 4P - 1029, Japanese


• 肥厚性偽関節の治療成績-偽関節組織の生物学的活性という視点より検討する-

  岩倉崇, 三輪雅彦, 酒井良忠, 新倉隆宏, 大江啓介, 黒坂昌弘

  2009, 骨折, 31(2) (2)


• 多発骨折例を含む骨盤、下肢骨折症例における静脈血栓塞栓症の発生状況

  新倉 隆宏, 三輪 雅彦, 酒井 良忠, 大江 啓介, 李 相亮, 岩倉 崇, 康 暁博, 黒坂 昌弘

  (公社)日本整形外科学会, 2009, 日本整形外科学会雑誌, 83(3) (3), S549 - S549, Japanese


• 生体内における炭酸ガス経皮吸収によるBohr効果の証明 新開発の経皮炭酸ガス治療器を用いて

  酒井 良忠, 三輪 雅彦, 大江 啓介, 李 相亮, 上羽 岳志, 田中 雅也, 黒坂 昌弘

  (公社)日本リハビリテーション医学会, 2009, The Japanese Journal of Rehabilitation Medicine, 46(Suppl.) (Suppl.), S184 - S184, Japanese


• 骨盤骨折症例における静脈血栓塞栓症の診断

  新倉 隆宏, 三輪 雅彦, 酒井 良忠, 大江 啓介, 李 相亮, 黒坂 昌弘

  中部日本整形外科災害外科学会, 2009, 中部日本整形外科災害外科学会雑誌, 52(春季学会) (春季学会), 123 - 123, Japanese


• 肥厚性偽関節の治療成績 偽関節組織の生物学的活性という視点より検討する

  岩倉 崇, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 大江 啓介, 黒坂 昌弘

  偽関節組織は骨形成能を有する肥厚性偽関節に存在するという観点から、骨癒合に有用な組織であると考えられている。そこで、著者らは偽関節組織を温存して肥厚性偽関節に対する手術を施行し、10症例(平均年齢35歳)を対象に治療成績を検討した。その結果、全例で骨癒合が得られ、骨癒合までの期間は平均4.4ヵ月であった。肥厚性偽関節由来細胞の生物学的活性に注目し、細胞解析および多分化能を調べたところ、偽関節組織中に骨髄間葉系幹細胞と同様な骨・軟骨・脂肪に分化可能な多分化能を有する間葉系幹細胞が存在することが初めて明らかになった。これによって肥厚性偽関節の偽関節組織は骨癒合に有用な組織であることが示唆された。以上より、肥厚性偽関節手術時には可能な限り偽関節組織を温存することにより、治療成績の向上が期待できると考えられた。

  (一社)日本骨折治療学会, 2009, 骨折, 31(2) (2), 405 - 409, Japanese


• 大腿骨、脛骨の偽関節に対する髄内釘入れ替えと骨髄刺激、自家骨移植による偽関節手術

  新倉 隆宏, 三輪 雅彦, 酒井 良忠, 大江 啓介, 岩倉 崇, 黒坂 昌弘

  著者らは大腿骨、脛骨の髄内釘入れ替えによる偽関節手術において骨形成能がより促進することを期待して、局所を展開し、骨髄刺激と腸骨からの海綿骨移植術を併用している。そこで今回、非感染性偽関節の7症例(大腿骨5例、脛骨2例)を対象に本法の有用性を検討した。その結果、1)大腿骨の1例を除き、全例で骨髄刺激と自家骨移植術が同時に行われ、脛骨遠位部の1例を除き、全例で骨癒合が得られた。2)再手術となった脛骨遠位部例に対しては遠位骨片に3本の横止めが行われたが、1本しか効いておらず、固定性が不良であったと考えられた。3)横止の位置や方向を変えること、あるいは脛骨プレート固定の追加等を考慮することが今後の検討課題であると思われた。

  (一社)日本骨折治療学会, 2009, 骨折, 31(2) (2), 410 - 413, Japanese


• 骨接合術が困難なpilon骨折に対するサルベージ手術としての順行性髄内釘法による足関節固定術

  新倉 隆宏, 三輪 雅彦, 酒井 良忠, 大江 啓介, 岩倉 崇, 黒坂 昌弘

  中部日本整形外科災害外科学会, 2008, 中部日本整形外科災害外科学会雑誌, 51(春季学会) (春季学会), 79 - 79, Japanese


• 肥厚性偽関節の治療成績 偽関節組織の生物学的活性という視点より検討する

  岩倉 崇, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 大江 啓介, 黒坂 昌弘

  (一社)日本骨折治療学会, 2008, 骨折, 30(Supplement) (Supplement), S164 - S164, Japanese


• 大腿骨、脛骨の偽関節に対する髄内釘入れ替えと自家骨移植による偽関節手術

  新倉 隆宏, 三輪 雅彦, 酒井 良忠, 大江 啓介, 岩倉 崇, 黒坂 昌弘

  (一社)日本骨折治療学会, 2008, 骨折, 30(Supplement) (Supplement), S165 - S165, Japanese


• 不安定型骨盤輪骨折後の偽関節に対して偽関節手術を行った1例

  大島 隆司, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 大江 啓介, 岩倉 崇, 土井田 稔, 黒坂 昌弘

  中部日本整形外科災害外科学会, 2008, 中部日本整形外科災害外科学会雑誌, 51(3) (3), 568 - 569, Japanese


• Fas ligandはラット由来骨髄間葉系細胞の骨分化を抑制する

  酒井 良忠, 三輪 雅彦, 大江 啓介, 新倉 隆宏, 岩倉 崇, 李 相亮, 黒坂 昌弘

  (公社)日本整形外科学会, 2008, 日本整形外科学会雑誌, 82(8) (8), S1157 - S1157, Japanese


• ヒト新鮮骨折において、低出力超音波パルス(LIPUS)は骨折血腫細胞の骨分化を促進する

  岩倉 崇, 長谷川 巧実, 三輪 雅彦, 新倉 隆宏, 酒井 良忠, 大江 啓介, 李 相亮, 黒坂 昌弘

  (公社)日本整形外科学会, 2008, 日本整形外科学会雑誌, 82(8) (8), S1195 - S1195, Japanese


• ヒトの骨折治癒過程に携わる骨折血腫細胞には骨形成蛋白が発現している

  新倉 隆宏, 三輪 雅彦, 酒井 良忠, 大江 啓介, 岩倉 崇, 長谷川 巧実, 黒坂 昌弘

  (公社)日本整形外科学会, 2008, 日本整形外科学会雑誌, 82(8) (8), S1259 - S1259, Japanese


• 楔状骨脱臼、脱臼骨折の治療経験

  新倉 隆宏, 三輪 雅彦, 酒井 良忠, 大江 啓介, 岩倉 崇, 黒坂 昌弘

  中部日本整形外科災害外科学会, 2008, 中部日本整形外科災害外科学会雑誌, 51(秋季学会) (秋季学会), 124 - 124, Japanese


• 骨折血腫細胞の多分化能についての検討と低出力超音波パルス(LIPUS)による効果について

  長谷川 巧実, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 大江 啓介, 岩倉 崇, 康 暁博, 澁谷 恭之, 黒坂 昌弘, 古森 孝英

  (公社)日本顎顔面インプラント学会, 2008, Japanese Journal of Maxillo Facial Implants, 7(2) (2), 171 - 171, Japanese


• Nondestructive evaluation of cell numbers in bone marrow stromal cells biodegradable scaffold composites using ultrasound.

  K. Oe, M. Miwa, K. Nagamune, Y. Sakai, R. Kuroda, T. Hasegawa, T. Iwakura, N. Shibanuma, Y. Hata, M. Kurosaka

  Sep. 2007, JOURNAL OF BONE AND MINERAL RESEARCH, 22, S242 - S242, English

  Summary international conference


• Ultrasound Fuzzy Evaluation System of Cellular Quantity

  山口聡至, 長宗高樹, 大江啓介, 近藤克哉, 小橋昌司, 畑豊

  In these years, a composite of artificial culture bone and bone marrow stromal cells (BMSCs) are hoped to effective treatment to large bone defect as impossible to curing for natural healing. Conventional evaluation method for the cellular quantity is firstly to crush the artificial culture bone injected BMSCs. So, the approximate amount of cell for curing is unknown. Therefore, this paper describes an ultrasound evaluation system for cellular quantity of artificial culture bone. Our system firstly measures ultrasound wave into the composite. And, we obtain two characteristics values. One of these values, the amplitude value, is directly measured by obtained wave. Another the frequency value is calculated by frequency spectrum converted with cross-spectrum method. We employ fuzzy inference using correlation of these values and true quantity for the cellular quantity. As a result, our method is able to evaluate the quantity with high accuracy.

  Japan Society for Fuzzy Theory and Intelligent Informatics, 2007, ファジィシステムシンポジウム講演論文集(CD-ROM), 23rd(0) (0), 739 - 739, Japanese


• 【研修医が知っておきたい整形外科診療必須マニュアル】 初期治療必須手技 脱臼と靱帯損傷

  大江 啓介, 三輪 雅彦, 黒田 良祐, 藤岡 宏幸, 黒坂 昌弘

  (株)メジカルビュー社, 2007, 関節外科, 26(4月増刊) (4月増刊), 122 - 125, Japanese


• 高度に粉砕したpilon骨折に対し順行性髄内釘を用い足関節固定術を施行した1例

  竹内 正史, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 大江 啓介, 黒坂 昌弘

  中部日本整形外科災害外科学会, 2007, 中部日本整形外科災害外科学会雑誌, 50(2) (2), 364 - 364, Japanese


• 整復固定が困難な脛骨天蓋骨折に対するサルベージ手術としての順行性髄内釘法による足関節固定術の経験

  新倉 隆宏, 三輪 雅彦, 酒井 良忠, 大江 啓介, 岩倉 崇, 黒坂 昌弘

  (一社)日本骨折治療学会, 2007, 骨折, 29(Supplement) (Supplement), S209 - S209, Japanese


• 偽関節部の組織には多分化能を有する細胞が存在する

  岩倉 崇, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 大江 啓介, 黒坂 昌弘

  (公社)日本整形外科学会, 2007, 日本整形外科学会雑誌, 81(8) (8), S1143 - S1143, Japanese


• 超音波を利用した骨髄細胞/人工骨複合体内導入細胞数の非破壊的定量法の開発

  大江 啓介, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 柴沼 均, 黒坂 昌弘

  (公社)日本整形外科学会, 2007, 日本整形外科学会雑誌, 81(8) (8), S1146 - S1146, Japanese


• β-リン酸三カルシウム(β-TCP)内への骨髄幹細胞(BMSC)導入方法と骨形成能の検討

  長谷川 巧実, 澁谷 恭之, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 大江 啓介, 岩倉 崇, 黒坂 昌弘, 古森 孝英

  (公社)日本口腔インプラント学会, 2007, 日本口腔インプラント学会誌, 37th(1) (1), 199 - 199, Japanese


• An Fuzzy Ultrasonic Nondestructive Evaluation System for Cellular Quantity in Artificial Culture Bone

  山口聡至, 長宗高樹, 大江啓介, 近藤克哉, 小橋昌司, 畑豊

  The Japan Joint Automatic Control Conference, 2006, 自動制御連合講演会(CD-ROM), 49th(0) (0), 95 - 95


• Development of Ultrasonic Nondestructive Evaluation System for the Cellular Quantity

  山口聡至, 長宗高樹, 大江啓介, 近藤克哉, 小橋昌司, 畑豊

  In this paper, we propose an ultrasonic nondestructive evaluation method for estimating cellular quantity in artificial culture bone by analyzing the ultrasonic wave. In order to measure the cellular quantity, we have to crush the culture bone and observed by the electro microscope. Therefore, they can't use the crashed culture bone in the research and the clinical. So we transmit ultrasound over the culture bone injected stem cell for getting a wave pattern. Our method analyzes these waves by fuzzy inference. As a result, we can estimate cellular quantity in culture bone with 60% accuracy.

  Japan Society for Fuzzy Theory and Intelligent Informatics, 2006, ファジィシステムシンポジウム講演論文集(CD-ROM), 22nd(0) (0), 99 - 99, Japanese


• VAC(Vaccum assisted closure)を用いて治癒し得た膝蓋骨骨折術後広範囲軟部組織欠損の1例

  川上 洋平, 三輪 雅彦, 酒井 良忠, 深澤 高広, 大江 啓介, 黒坂 昌弘, 宮村 卓, 寺師 浩人, 田原 真也

  中部日本整形外科災害外科学会, 2006, 中部日本整形外科災害外科学会雑誌, 49(1) (1), 189 - 189, Japanese


• 頸髄サルコイドーシスの4例(病態,画像の特徴,圧迫性脊髄症との鑑別および治療指針についての検討)

  宮本 裕史, 大江 啓介, 鷲見 正敏, 宇野 耕吉, 高畑 正人, 乾 義弘, 田所 浩, 恵美 直敦

  (一社)日本脊椎脊髄病学会, 2006, 日本脊椎脊髄病学会雑誌, 17(1,Pt.2) (1,Pt.2), 534 - 534, Japanese


• 上腕三頭筋腱皮下断裂を生じた2例

  深瀬 直政, 大江 啓介, 橋本 靖, 芝 昌彦, 石井 憲治, 橋本 慎吾, 大野 修

  中部日本整形外科災害外科学会, 2006, 中部日本整形外科災害外科学会雑誌, 49(4) (4), 803 - 803, Japanese


• 【脊椎疾患における鑑別診断と治療法選択の根拠】 鑑別診断とその根拠 頸椎 頸髄症とサルコイドーシス、多発性硬化症などの鑑別 頸椎症性脊髄症と脊髄サルコイドーシスの鑑別

  大江 啓介, 宮本 裕史, 土井田 稔, 鷲見 正敏, 苅田 典生

  脊髄サルコイドーシスと最終診断された4症例(男2例、女2例、41〜59歳・平均53.5歳)の病態と画像所見を呈示し、脊髄サルコイドーシスと頸椎症性脊髄症(CSM)との鑑別及び治療方針について概説した。初診時全症例で進行性の脊髄症を呈し、治療前に全例に対しMRIを撮像したが、当初より脊髄サルコイドーシスを疑った3例にはGd-DTPA造影MRIを施行した。治療としてはCSMを疑った1例には片開き式頸部脊柱管拡大術(拡大術)を、CSMと神経筋疾患の合併を疑った2例には圧迫因子の除去目的で拡大術を施行した。全例にステロイドパルス療法を施行し、残る1例にはステロイドパルス療法のみを施行した。診断のポイントとしては腱反射・知覚障害・筋力低下など臨床所見とMRIなど画像所見の最狭窄高位との間の一致性がない場合はサルコイドーシスなど神経筋疾患を考慮する。サルコイドーシスの可能性が考慮された場合には胸部単純X線撮影・ACE・リゾチーム・ツベルクリン反応などのスクリーニング検査を行い、サルコイドーシスの可能性が高い場合は陽性所見を得る可能性の高い生検を施行して鑑別診断する。

  (株)南江堂, 2006, 別冊整形外科, (50) (50), 2 - 8, Japanese


• Vacuum-assisted closureを用いて治癒しえた膝蓋骨骨折術後広範囲軟部組織欠損の1例

  川上 洋平, 三輪 雅彦, 酒井 良忠, 深澤 高広, 大江 啓介, 黒坂 昌弘, 宮村 卓, 田原 真也

  50歳男。自転車で転倒し、左膝蓋骨骨折の診断にて骨接合術を施行したが離開を認め、再骨接合術(circler wiring法)を施行した。しかし、その後も徐々に骨折部の離開が進行し、再々骨接合術を行った。翌日より40℃の発熱と、膝前面の皮膚の壊死を認め、抜釘および洗浄を施行し、手術時の創部培養にてMRSAを認めた。左膝前面に約15×5cmの皮膚および軟部組織の欠損を認め、大腿骨顆部が露出しており、膝蓋骨も離開し露出していた。可動域(ROM)は-30°〜40°と高度に伸展・屈曲制限していた。単純X線側面像では膝蓋骨の離開を認め、MRIでは矢状断像で左膝全面皮下に広範囲な炎症像が広がっていた。入院後、急激に全身状態が増悪し、播種性血管内凝固症候群(DIC)となり、vacuum-assisted closure(VAC)療法を開始した。治療開始20日後には鮮紅色の良好な肉芽にて創部は閉鎖され、明らかな浸出液の減少を認めたため、植皮可能と判断して21日目に全身麻酔下に極薄分層植皮術を施行した。植皮はほぼ全域で生着し、術後48日目に退院した。治療後1年4ヵ月の現在、ROM・膝伸展筋力は入院時と変化ないが、感染徴候や疼痛は認めず独歩可能である。

  (株)南江堂, 2006, 整形外科, 57(13) (13), 1737 - 1740, Japanese


• 骨折血腫には多分化能を有する細胞が存在する

  大江 啓介, 三輪 雅彦, 酒井 良忠, 李 相亮, 黒田 良祐, 黒坂 昌弘

  (公社)日本整形外科学会, 2006, 日本整形外科学会雑誌, 80(8) (8), S969 - S969, Japanese


• 肺経由動脈熱希釈法(PiCCO)を用いた呼吸・循環動態のモニタリングの検討

  高橋 晃, 川嶋 隆久, 吉田 剛, 陵城 成浩, 大江 啓介, 文 宣貴, 岡田 直己, 中尾 博之, 前田 裕仁, 石井 昇

  (一社)日本救急医学会, Aug. 2005, 日本救急医学会雑誌, 16(8) (8), 386 - 386, Japanese


• 肺経由動脈熱希釈法(PiCCO)を用いた呼吸・循環動態のモニタリングの検討

  高橋晃, 川嶋隆久, 吉田剛, 陵城成浩, 大江啓介, 文宣貴, 岡田直己, 中尾博之, 前田裕仁, 石井昇

  2005, 日本救急医学会雑誌, 16(8) (8)


• 臨床研修必修化と国立大学独立法人化に伴う諸問題

  川嶋 隆久, 中尾 博之, 石井 昇, 陵城 成浩, 吉田 剛, 高橋 晃, 岡田 直己, 前田 裕仁, 大江 啓介

  (一社)日本救急医学会, 2005, 日本救急医学会雑誌, 16(8) (8), 336 - 336, Japanese


• 骨盤骨折に対するTAE(経カテーテル的動脈塞栓術)の適応 無輸血治療をめざして

  大江 啓介, 川嶋 隆久, 前田 裕仁, 中尾 博之, 岡田 直己, 高橋 晃, 文 宣貴, 吉田 剛, 陵城 成浩, 石井 昇, 大森 裕

  (一社)日本救急医学会, 2005, 日本救急医学会雑誌, 16(8) (8), 451 - 451, Japanese


• CPAOA症例における搬入時直腸温と鼓膜温の解離についての検討(第2報)

  陵城 成浩, 川嶋 隆久, 石井 昇, 吉田 剛, 文 宣貴, 高橋 晃, 岡田 直己, 前田 裕仁, 中尾 博之, 大江 啓介

  (一社)日本救急医学会, 2005, 日本救急医学会雑誌, 16(8) (8), 458 - 458, Japanese


• 頸椎症性脊髄症と鑑別を必要とした脊髄サルコイドーシスの4例

  大江 啓介, 鷲見 正敏, 下村 隆敏, 苅田 典生

  中部日本整形外科災害外科学会, 2004, 中部日本整形外科災害外科学会雑誌, 47(春季学会) (春季学会), 152 - 152, Japanese


• 頸椎多椎間後方除圧固定術術後に発症したC5麻痺の2例

  鄭 克真, 鷲見 正敏, 田所 浩, 宮本 裕史, 高畑 正人, 乾 義弘, 熊谷 宏, 矢野 智則, 大江 啓介

  中部日本整形外科災害外科学会, 2004, 中部日本整形外科災害外科学会雑誌, 47(3) (3), 598 - 598, Japanese


• 踵部難治性潰瘍に対して分層植皮を施行したWerner症候群の1例

  大江 啓介, 三輪 雅彦, 酒井 良忠, 吉矢 晋一, 黒坂 昌弘, 宮村 卓

  中部日本整形外科災害外科学会, 2004, 中部日本整形外科災害外科学会雑誌, 47(5) (5), 1117 - 1117, Japanese


• Four cases of spinal cord sarcoidosis in cervical leasion which mimicked cervical spondylotic myelopathy

  大江啓介, 鷲見正敏, 下村隆敏, 苅田典生

  症例1:56歳女.歩行障害,両上肢のしびれを主訴とした.C5/6椎間にX線で動的狭窄因子を,脊髄造影でブロック像を認めた.MRIのT2強調像で髄内高輝度陰影を広範囲に認めたが,頸椎症性脊髄症を疑い脊柱管拡大術を行った.術後右上下肢の麻痺が出現し,造影MRIで髄内造影像を認めた.脊髄サルコイドーシス(本症)と診断し,ステロイド剤投与を開始したが,症状は改善しなかった.症例2:58歳女.手指巧緻運動および歩行障害を主訴とした.MRIで髄内高輝度陰影と造影像を認め,神経疾患を疑って脊柱管拡大術を施行した後,精査で本症と診断した.ステロイド剤投与を行ったが,全身性に進行して症状は悪化した.症例3:59歳男.手指巧緻運動および歩行障害を主訴とした.脊柱管拡大術後に本症と診断してステロイド剤を投与したが,脊髄症は不変であった.症例4:41歳男.歩行障害を主訴とした.画像所見より神経疾患を疑い,本症と診断した.ステロイド剤を投与し,脊髄症は若干改善した

  中部日本整形外科災害外科学会, 2004, 中部日本整形外科災害外科学会雑誌, 47(6) (6), 1205 - 1206, Japanese


• 上腕三頭筋腱皮下断裂を生じた1例

  大江 啓介, 荷田 啓一郎, 橋本 靖, 芝 昌彦, 山本 晃裕, 大野 修

  中部日本整形外科災害外科学会, Jul. 2003, 中部日本整形外科災害外科学会雑誌, 46(4) (4), 767 - 767, Japanese


• 当院における鏡視下腰椎椎間板ヘルニア切除術

  橋本 靖, 芝 昌彦, 荷田 啓一郎, 山本 晃裕, 大江 啓介, 大野 修

  三田市民病院, Mar. 2003, 三田市民病院誌, 15, 7 - 11, Japanese


• Femoral neck fracture after removal of the gamma nail. A case report.

  正田悦朗, 富田佳孝, 岡本剛治, 前田啓志, 大江啓介, 美ふね泰

  76歳女.約40年慢性関節リウマチで通院していたが,転倒し,左大腿骨転子部骨折をきたし,ガンマネイルによる骨接合術を行った.術後3日から車椅子へ移動を展開し,術後4週から病棟歩行器歩行可能となり,1本杖歩行で退院した.経過観察したが,全身の関節痛が強く,歩行が徐々に困難となり,寝ている時間が増加した.体重が減少し臀部から大腿にかけ痩せてきたため,ラグスクリュー先端部が突出し疼痛を強く訴えた.ラグスクリューを抜釘したところ抵抗感はなかったが,術後のX線で大腿骨頸部骨折を認めたため,人工骨頭置換術を施行した.術後6週で荷重歩行が可能となり退院した

  (株)メジカルビュー社, 2003, 関節外科, 22(1) (1), 116 - 118, Japanese


• 大腿骨頸部外側骨折に対するProximal Femoral Nail(PFN)を使用した治療成績

  荷田 啓一郎, 大江 啓介, 山本 晃裕, 小村 孝, 芝 昌彦, 橋本 靖, 大野 修

  (公社)日本整形外科学会, 2003, 日本整形外科学会雑誌, 77(3) (3), S37 - S37, Japanese


• 上腕骨近位部骨折に対するPolarus nailの使用経験

  前田 啓志, 正田 悦朗, 冨田 佳孝, 岡本 剛治, 大江 啓介

  上腕骨近位部骨折4例(男1例,女3例,平均73歳)に対して,Polarus nailを使用して骨接合術を行った.経過観察期間は平均11ヵ月であった.3例がNeer分類2part骨折で,1例が3part骨折であった.Neerの治療成績評価基準でsatisfactoryが2例で,unsatisfactoryが1例,failureが1例であった.成績不良例の原因は可動域の制限であった.疼痛部位は切開を加えた腱板部ではなく,全例近位のscrew head部であった

  (一社)日本骨折治療学会, 2003, 骨折, 25(2) (2), 630 - 632, Japanese


• 小児上腕骨顆上骨折に同側の前腕骨遠位部骨折を合併した3例

  大江 啓介, 正田 悦朗, 前田 啓志, 冨田 佳孝, 岡本 剛治

  上腕骨顆上骨折に同側の前腕骨骨折を合併した小児3例(症例1:4歳,症例2:10歳,症例3:7歳,全例男児)について検討した.経過観察期間は平均31.7ヵ月で,1例は上腕骨遠位骨端線離開であったが,前腕の骨折部位は3例とも遠位部であった.受傷機転は全例が高所からの転落であった.治療は症例1では上腕骨遠位は観血的骨接合,症例2では上腕,前腕共に徒手整復,症例3では上腕,前腕共に徒手整復後,経皮的ピンニングを行った.手関節に可動域制限はなかったが,肘関節の治療成績はFlynnの評価基準でfunctional factorが症例1でgood,症例2,3でpoor,cosmetic factorが症例1,3でfair,症例2でgoodであった.現在のところ3例とも日常生活やスポーツに支障はないが,軽度内反変形と可動域制限が残存している

  (一社)日本骨折治療学会, 2003, 骨折, 25(2) (2), 701 - 704, Japanese


• Charcot足関節症に対してallograftを用いて足関節固定術を行った一例

  岡本 剛治, 正田 悦朗, 冨田 佳孝, 前田 啓志, 大江 啓介

  日本足の外科学会, May 2002, 日本足の外科学会雑誌, 23(1) (1), S98 - S98, Japanese


• Partial rupture of the extensor pollicis longus tendon combined with avulsion fracture of the Lister tubercle.

  大江啓介, 正田悦朗, 前田啓志, 岡本剛治, 冨田佳孝

  85歳男.歩行中に左手をついて転倒した.左手関節の腫脹,疼痛が出現し,著明となったため受診した.単純X線所見では左橈骨遠位端骨折とLister結節の剥離骨折を認めた.Lister結節の剥離骨折部に長母指伸筋(EPL)が挟み込まれ,断裂が生じる可能性が高いと判断し,直視下に観血的骨接合術を施行した.EPLは背側に転位したLister結節の骨片と母床に挟み込まれて部分断裂をきたしていた.固定性は良好であったが,EPLの部分断裂も存在したため術後4週間のギプス固定を行った.単純X線上,術後3週で仮骨が出現し,術後6週で骨癒合と判断した.疼痛や腫脹はなく,又,母指IPの伸展障害もみられなかった.術後12週でZ-wireとmini-screwの抜釘術を施行した.この時EPLの状態を確認したが,部分断裂部は完全に修復していた

  (株)メジカルビュー社, 2002, 関節外科, 21(4) (4), 498 - 500, Japanese


• Mosaicplasty後に骨軟骨プラグ採取部膨隆による疼痛を生じた1例

  正田 悦朗, 冨田 佳孝, 岡本 剛治, 前田 啓志, 大江 啓介, 飯田 康夫, 黒田 司

  18歳女.右膝関節内転後の疼痛,腫脹で受診した.X線で内側関節裂隙の狭小化を認め,MRIでは内側半月の描出が悪く,大腿骨内顆にlow signalを呈する部分があり,ACLも描出されなかった.関節鏡検査では,内側半月にbucket-handle tearが存在し,切除を行ったところ大腿骨内顆に軟骨損傷があり軟骨下骨が露出していた.ACLは瘢痕が存在するのみであった.膝蓋腱を用いたACL再建術と同時に軟骨損傷部にmosaicplastyを行った.術後1年7ヵ月後,大腿骨内顆部の疼痛で再受診した.X線では内側部に骨性の膨隆がみられ,MRIでは骨軟骨採取部の関節面が膨隆しており,関節鏡下に膨隆部分をシェービングした.その後,疼痛は軽快したが,術後3年で内側関節裂隙の狭小化が進んできている

  (株)文光堂, 2002, 臨床スポーツ医学, 19(7) (7), 829 - 833, Japanese


• Unreamed nailによる下腿開放骨折の治療

  正田 悦朗, 飯田 康夫, 岡本 剛治, 前田 啓志, 大江 啓介, 櫻井 敦志, 澤村 悟, 庄 智矢

  1994年以降,下腿開放骨折に対し全例unreamed nail(URN)を使用してきたが,URNを使用した20例と,URN使用以前に従来のreamingを行うnail(RN)を使用した7例を比較検討した.手術時間はURNで平均68分,RNで83分と,URNの方が短かったが,仮骨出現時期と骨癒合時期はそれぞれURNで平均6.2週,23.3週,RNで平均3.4週,16.7週と有意差はないが,RNの方が早かった.URNが下腿開放骨折の治療に有利であるという結果は得られず,URNの適応は,開放骨折の一次的内固定,多発骨折例や多発外傷例で肺合併症がある場合,軟部組織損傷が強い例に限った方が良いと考えられた

  (一社)日本骨折治療学会, 2002, 骨折, 24(1) (1), 323 - 326, Japanese


• Elastofibroma dorsi found incidentally in the follow-up of a treated lung cancer: A case report.

  大江啓介, 門沢秀一, 山路滋, 高田佳木, 松本圭司, 正田悦朗

  71歳男.69歳時に肺小細胞癌(T2N3M1)で化学療法施行の既往があり,右肩甲下部腫瘤を家族に指摘された.腫瘤は6×3cm大,弾性硬で圧痛はなく,右上肢運動に伴う可動性を認めた.MRIのT1強調像では腫瘤は筋肉と同程度の信号強度を示し,内部に脂肪を思わせる線状〜網状の高信号域を認め,脂肪抑制T2強調像では筋肉と同程度の信号を示す部分と低信号を示す部分が混在して認められた.更に3ヵ月後に施行の造影CT所見では右広背筋と胸壁の間に凸レンズ状の腫瘤を認め内部に脂肪濃度は認められなかった.以上の所見から背部弾性線維腫と診断され,患者が希望しない為,生検は施行せずに経過観察となった.肺癌の胸壁への転移との鑑別では,約2年前の造影CTでも腫瘤が同様に認められていたことから否定的と考えられた

  兵庫県立がんセンター, 2000, 兵庫県立成人病センター紀要, 17, 27 - 30, Japanese

• 骨折関連感染症に対する持続局所抗菌薬灌流(CLAP)の有効性 多施設研究

  高原 俊介, 川崎 一旭, 吉田 健亮, 善家 雄吉, 姫野 大輔, 山下 伸之輔, 松本 匡洋, 山川 泰明, 森井 北斗, 大江 啓介, 新倉 隆宏, 圓尾 明弘

  整形外科と災害外科, May 2024, Japanese, 西日本整形・災害外科学会


• 持続局所抗菌薬灌流(CLAP)が骨折関連感染症治療における医療費に与える影響

  吉田 健亮, 高原 俊介, 川崎 一旭, 善家 雄吉, 姫野 大輔, 山下 伸之輔, 松本 匡洋, 山川 泰明, 森井 北斗, 大江 啓介, 新倉 隆宏, 圓尾 明弘

  整形外科と災害外科, May 2024, Japanese, 西日本整形・災害外科学会


• 細菌性腹膜炎への腹腔内222nmUVC照射による腹水中細菌制御効果と安全性の検証

  杉山 洸裕, 立田 協太, 小嶋 忠浩, 赤井 俊也, 鈴木 克徳, 鳥居 翔, 阪田 麻裕, 森田 剛文, 菊池 寛利, 平松 良浩, 隈部 洋平, 大江 啓介, 福井 友章, 黒田 良祐, 倉地 清隆, 竹内 裕也

  日本外科学会定期学術集会抄録集, Apr. 2024, Japanese, (一社)日本外科学会


• 当院の二次性骨折予防継続管理の取り組みとその成果

  岩倉 崇, 安部 真人, 堂垣 佳宏, 西本 浩司, 大江 啓介, 角田 雅也

  中部日本整形外科災害外科学会雑誌, Apr. 2024, Japanese, (一社)中部日本整形外科災害外科学会


• 人工股関節ステム周囲骨折後偽関節の治療経験

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  中部日本整形外科災害外科学会雑誌, Apr. 2024, Japanese, (一社)中部日本整形外科災害外科学会


• 膝関節が露出した膝蓋骨骨折術後感染をCLAPと腓腹筋弁によりサルベージした一例

  藤原 悠, 大江 啓介, 福井 友章, 隈部 洋平, 黒田 良祐

  中部日本整形外科災害外科学会雑誌, Apr. 2024, Japanese, (一社)中部日本整形外科災害外科学会


• 人工膝関節全置換術後の細菌感染治療経過中に真菌感染をきたし、一期的に再置換術を施行した一例

  菅野 龍彦, 松本 知之, 中野 直樹, 壺坂 正徳, 大江 啓介, 黒田 良祐

  中部日本整形外科災害外科学会雑誌, Apr. 2024, Japanese, (一社)中部日本整形外科災害外科学会


• 【骨折治療の現在地を知る!】感染・偽関節 偽関節患者に対する自家末梢血CD34陽性細胞移植による骨・血管再生医療について

  大江 啓介, 新倉 隆宏, 福井 友章, 隈部 洋平, 松本 知之, 黒田 良祐

  整形・災害外科, Apr. 2024, Japanese, 金原出版(株)


• 非定型大腿骨骨折において骨転移に対する骨修飾薬使用歴の有無が治療経過に与える影響

  福井 友章, 大江 啓介, 隈部 洋平, 新倉 隆宏, 黒田 良祐

  日本整形外科学会雑誌, Mar. 2024, Japanese, (公社)日本整形外科学会


• 大腿骨近位部骨折の早期手術を妨げる要因は何か

  石村 颯貴, 岩倉 崇, 伊藤 克拓, 安部 真人, 大江 啓介, 堂垣 佳宏, 西本 浩司, 角田 雅也

  日本整形外科学会雑誌, Mar. 2024, Japanese, (公社)日本整形外科学会


• CLAPにおけるゲンタマイシンの薬物動態に関する検討

  松宮 豊, 大江 啓介, 福井 友章, 隈部 洋平, 黒田 良祐

  日本整形外科学会雑誌, Mar. 2024, Japanese, (公社)日本整形外科学会


• 骨折関連感染症に対する持続局所抗菌薬灌流の有効性 多施設研究

  高原 俊介, 善家 雄吉, 姫野 大輔, 松本 匡洋, 森井 北斗, 大江 啓介, 新倉 隆宏, 圓尾 明弘

  日本整形外科学会雑誌, Mar. 2024, Japanese, (公社)日本整形外科学会


• AMED事業で進む運動器再生医療-臨床研究と医師主導治験- 多施設医師主導治験「自家末梢血CD34陽性細胞移植による骨・血管再生」

  黒田 良祐, 松本 知之, 大江 啓介, 福井 友章, 美舩 泰, 新倉 隆宏

  日本整形外科学会雑誌, Mar. 2024, Japanese, (公社)日本整形外科学会


• 骨折関連感染症に対する有効性と安全性を意識した持続局所抗菌薬灌流(CLAP)の実際

  高原 俊介, 圓尾 明弘, 善家 雄吉, 姫野 大輔, 新倉 隆宏, 大江 啓介, 松本 匡洋, 森井 北斗, 青木 謙二, 中川 夏子, 高山 博行

  日本整形外科学会雑誌, Mar. 2024, Japanese, (公社)日本整形外科学会


• 四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  中部日本整形外科災害外科学会雑誌, Oct. 2023, Japanese, (一社)中部日本整形外科災害外科学会


• Mycobacterium abscessus complex感染による骨髄炎・化膿性関節炎を持続局所抗菌薬灌流で治療した一例

  藤田 大樹, 新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  中部日本整形外科災害外科学会雑誌, Oct. 2023, Japanese, (一社)中部日本整形外科災害外科学会


• 特徴的画像所見を示した脛骨慢性骨髄炎の一例

  古川 太河, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐

  中部日本整形外科災害外科学会雑誌, Oct. 2023, Japanese, (一社)中部日本整形外科災害外科学会


• 前十字靱帯再建術後感染に対して持続局所抗菌薬灌流療法を行い,移植腱を温存し得たプロサッカー選手の1例

  吉田 純伶, 松下 雄彦, 大江 啓介, 長井 寛斗, 西田 京平, 神崎 至幸, 星野 祐一, 黒田 良祐

  中部日本整形外科災害外科学会雑誌, Sep. 2023, Japanese, (一社)中部日本整形外科災害外科学会


• 3D造形βTCP人工骨の生体活性の検討

  高瀬 恭平, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 山本 裕也, 西田 亮太, 新倉 隆宏, 黒田 良祐

  日本整形外科学会雑誌, Aug. 2023, Japanese, (公社)日本整形外科学会


• 異なる抗菌薬濃度により骨髄由来細胞が受ける影響の検討

  山本 裕也, 大江 啓介, 福井 友章, 澤内 健一, 吉川 遼, 高瀬 恭平, 西田 亮太, 新倉 隆宏, 圓尾 明弘, 黒田 良祐

  日本整形外科学会雑誌, Aug. 2023, Japanese, (公社)日本整形外科学会


• Masquelet法induced membrane由来細胞に対するLIPUSの骨分化促進効果の検討

  高瀬 恭平, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 山本 裕也, 西田 亮太, 新倉 隆宏, 黒田 良祐

  日本整形外科学会雑誌, Aug. 2023, Japanese, (公社)日本整形外科学会


• 廃用性骨萎縮・筋萎縮に対する炭酸ガス経皮吸収の予防効果

  西田 亮太, 大江 啓介, 福井 友章, 澤内 健一, 山本 裕也, 高瀬 恭平, 吉川 遼, 新倉 隆宏, 黒田 良祐

  日本整形外科学会雑誌, Aug. 2023, Japanese, (公社)日本整形外科学会


• 大腿骨頚部骨折患者における骨粗鬆症治療薬介入とステム周囲骨密度変化率の関係について―多施設共同研究―

  大江啓介

  第49回日本骨折治療学会学術集会, Jul. 2023, Japanese

  Oral presentation


• 当院における慢性骨髄炎に対する持続局所抗菌薬灌流療法（CLAP）の治療成績

  大江啓介

  第49回日本骨折治療学会学術集会, Jun. 2023, Japanese

  Oral presentation


• 当院における化膿性関節炎に対する持続局所抗菌薬灌流療法（CLAP）の治療成績

  大江啓介

  第46回日本骨・関節感染症学会, Jun. 2023, Japanese

  Oral presentation


• 大腿骨骨欠損をMasquelet法で治療する際の移植骨局所担持のための工夫

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会


• CLAP(1) 骨髄由来細胞に対する高濃度抗菌薬の影響

  山本 裕也, 大江 啓介, 福井 友章, 澤内 健一, 高瀬 恭平, 西田 亮太, 新倉 隆宏, 圓尾 明弘, 黒田 良祐

  骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会


• CLAP(1) 当院における慢性骨髄炎に対する持続局所抗菌薬灌流療法(CLAP)の治療成績

  大江 啓介, 福井 友章, 黒田 良祐, 新倉 隆宏

  骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会


• LIPUSのMasquelet法induced membrane由来細胞に対する骨分化促進効果の検討

  高瀬 恭平, 福井 友章, 大江 啓介, 山本 裕也, 西田 亮太, 新倉 隆宏, 黒田 良祐

  骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会


• がん骨転移に対する骨修飾薬使用歴が非定型大腿骨骨折の治療経過に与える影響に関する後ろ向き観察研究

  福井 友章, 大江 啓介, 澤内 健一, 新倉 隆宏, 黒田 良祐

  骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会


• 四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会


• 当院ヒップフラクチャーセンターにおける二次性骨折予防継続管理料、緊急整復固定・緊急挿入加算算定の状況

  脇 貴洋, 福本 弦太, 大江 啓介, 矢野 智則, 伊藤 研二郎, 松島 真司

  骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会


• Hip fracture templateは大腿骨近位部骨折手術における周術期合併症を減少させる

  脇 貴洋, 福本 弦太, 大江 啓介, 矢野 智則, 伊藤 研二郎, 松島 真司

  骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会


• 大腿骨頸部骨折患者における骨粗鬆症治療薬介入とステム周囲骨密度変化率の関係について 多施設共同研究

  大江 啓介, 福井 友章, 澤内 健一, 松宮 豊, 黒田 良祐, 新倉 隆宏

  骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会


• 炭酸ガス経皮吸収と低出力超音波パルス療法(LIPUS)併用のラット大腿骨骨折治癒に対する効果

  西田 亮太, 澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 山本 裕也, 高瀬 恭平, 吉川 遼, 黒田 良祐

  骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会


• Mycobacterium abscessus complex感染による骨髄炎・化膿性関節炎を持続局所抗菌薬灌流で治療した一例

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  骨折, Jun. 2023, Japanese, (一社)日本骨折治療学会


• 高濃度抗菌薬が骨髄由来細胞の増殖能および分化能に与える影響

  山本 裕也, 大江 啓介, 福井 友章, 澤内 健一, 吉川 遼, 高瀬 恭平, 西田 亮太, 新倉 隆宏, 圓尾 明弘, 黒田 良祐

  日本骨・関節感染症学会プログラム・抄録集, Jun. 2023, Japanese, (一社)日本骨・関節感染症学会


• CLAPにおけるゲンタマイシンの血中濃度、排液中濃度と排液量の関係

  松宮 豊, 大江 啓介, 福井 友章, 澤内 健一, 新倉 隆宏, 黒田 良祐

  日本骨・関節感染症学会プログラム・抄録集, Jun. 2023, Japanese, (一社)日本骨・関節感染症学会


• 持続局所抗菌薬灌流(CLAP)による骨折関連感染症の骨癒合経過 多施設研究

  高原 俊介, 善家 雄吉, 姫野 大輔, 松本 匡洋, 森井 北斗, 大江 啓介, 新倉 隆宏, 圓尾 明弘

  日本骨・関節感染症学会プログラム・抄録集, Jun. 2023, Japanese, (一社)日本骨・関節感染症学会


• 骨SPECT/CTにおける偽関節モデルファントムを用いた金属インプラントのCT減弱補正に関する研究

  大江啓介

  第96回日本整形外科学会学術総会, May 2023, Japanese

  Oral presentation


• インプラント周囲に生じた非定型大腿骨骨折について

  大江啓介

  外傷整形外科webシンポジウム AFF 骨折研究会, Apr. 2023, Japanese

  [Invited]

  Nominated symposium


• 超音波治療の世界(基礎と臨床) LIPUSによる骨折治癒促進

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  超音波医学, Apr. 2023, Japanese, (公社)日本超音波医学会


• 軟部組織欠損を伴った脛骨慢性骨髄炎病的骨折に対するCLAPを用いた新しい治療戦略

  大江啓介

  第25回救急整形外傷シンポジウム, Mar. 2023, Japanese

  Oral presentation


• Hip fracture templateは大腿骨近位部骨折手術における周術期合併症を減少させる

  脇 貴洋, 石丸 直人, 下川 敏雄, 大江 啓介, 水木 真平, 大西 潤, 官澤 洋平, 矢野 智則, 伊藤 研二郎, 松島 真司, 木南 佐織

  日本整形外科学会雑誌, Mar. 2023, Japanese, (公社)日本整形外科学会


• メッシュプレートを用いて内固定を行った母趾基節骨偽関節の2例

  大野 裕也, 福井 友章, 大江 啓介, 澤内 健一, 黒田 良祐

  中部日本整形外科災害外科学会雑誌, Mar. 2023, Japanese, (一社)中部日本整形外科災害外科学会


• 骨SPECT/CTにおける偽関節モデルファントムを用いた金属インプラントのCT減弱補正に関する研究

  大江 啓介, 福井 友章, 澤内 健一, 新倉 隆宏, 黒田 良祐

  日本整形外科学会雑誌, Mar. 2023, Japanese, (公社)日本整形外科学会


• ここまできた!骨・軟骨再生医療の最前線 偽関節患者に対する自家末梢血CD34陽性細胞移植による骨・血管再生医療

  大江 啓介, 新倉 隆宏, 福井 友章, 澤内 健一, 黒田 良祐

  日本整形外科学会雑誌, Mar. 2023, Japanese, (公社)日本整形外科学会


• 四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  日本整形外科学会雑誌, Mar. 2023, Japanese, (公社)日本整形外科学会


• 患者立脚型QOL評価を用いた大腿骨および脛骨偽関節の術後成績の検討

  福井 友章, 新倉 隆宏, 大江 啓介, 澤内 健一, 黒田 良祐

  日本整形外科学会雑誌, Mar. 2023, Japanese, (公社)日本整形外科学会


• 脛骨慢性骨髄炎病的骨折に対しCLAPを併用し骨接合術と遊離皮弁術を同時に行った1例

  牟田口 由紀子, 澤内 健一, 大江 啓介, 福井 友章, 黒田 良祐

  中部日本整形外科災害外科学会雑誌, Mar. 2023, Japanese, (一社)中部日本整形外科災害外科学会


• インプラント周囲非定型大腿骨骨折の病態と治療法について

  大江啓介

  第49回日本股関節学会学術集会, Oct. 2022, Japanese

  [Invited]

  Nominated symposium


• 骨・軟部組織感染症の診断と治療

  大江啓介

  第169回 神戸地区症例検討会, Sep. 2022, Japanese

  Public discourse


• 創外固定の基礎

  大江啓介

  Sep. 2022, Japanese

  [Invited]

  Public discourse


• 炭酸ガス経皮吸収療法と低出力超音波パルス療法(LIPUS)の併用はラットの骨折治癒を促進する

  澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 山本 裕也, 高瀬 恭平, 吉川 遼, 黒田 良祐

  日本整形外科学会雑誌, Sep. 2022, Japanese, (公社)日本整形外科学会


• Masquelet法 Induced membrane由来細胞に対するLIPUSによる骨分化誘導

  高瀬 恭平, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 山本 裕也, 黒田 良祐

  日本整形外科学会雑誌, Sep. 2022, Japanese, (公社)日本整形外科学会


• Non-hypertrophic nonunionには骨分化能を有する細胞が存在し、E-BMP-2により骨・軟骨分化能が促進される

  吉川 遼, 新倉 隆宏, 福井 友章, 大江 啓介, 隈部 洋平, 小田 崇弘, 澤内 健一, 高瀬 恭平, 山本 裕也, 酒井 良忠, 黒田 良祐

  日本整形外科学会雑誌, Sep. 2022, Japanese, (公社)日本整形外科学会


• 骨折遷延治癒、偽関節のメカニズムから臨床応用へ 炭酸ガス経皮吸収による骨癒合促進

  新倉 隆宏, 大江 啓介, 福井 友章, 澤内 健一, 高瀬 恭平, 黒田 良祐

  日本整形外科学会雑誌, Sep. 2022, Japanese, (公社)日本整形外科学会


• 骨組織由来細胞に対する高濃度抗菌薬の影響

  山本 裕也, 新倉 隆宏, 福井 友章, 大江 啓介, 高瀬 恭平, 吉川 遼, 澤内 健一, 圓尾 明弘, 黒田 良祐

  日本整形外科学会雑誌, Sep. 2022, Japanese, (公社)日本整形外科学会


• 寛骨臼転移性骨腫瘍に対して病巣掻爬後に内固定および骨セメント充填を行った3例

  大江啓介

  第48回日本骨折治療学会学術集会, Jun. 2022, Japanese

  [Invited]

  Nominated symposium


• 高齢大腿骨頚部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化について-多施設共同研究-

  大江啓介

  第48回日本骨折治療学会学術集会, Jun. 2022, Japanese

  Oral presentation


• 高齢大腿骨頚部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について ―多施設共同前向き観察研究―

  大江啓介

  May 2022, Japanese

  Oral presentation


• CT有限要素法を用いたReamer Irrigator Aspirator施行前後の大腿骨強度変化についての検討

  大江啓介

  第95回日本整形外科学会学術総会, May 2022, Japanese

  Poster presentation


• 大腿骨近位髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について―多施設共同前向き観察研究―

  大江啓介

  第138回中部日本整形外科災害外科学会・学術集会, Apr. 2022, Japanese

  Oral presentation


• KLF15を介した筋萎縮の分子機構の解明

  平田 悠, 野村 和弘, 加藤 大輔, 橘 吉寿, 新倉 隆宏, 内山 奏, 細岡 哲也, 福井 友章, 大江 啓介, 黒田 良祐, 原 雄二, 安達 貴弘, 柴崎 貢志, 和氣 弘明, 小川 渉

  糖尿病, Apr. 2022, Japanese, (一社)日本糖尿病学会


• 骨形成不全症患者に生じた非定型大腿骨骨折の1例

  上出 將志, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  中部日本整形外科災害外科学会雑誌, Apr. 2022, Japanese, (一社)中部日本整形外科災害外科学会


• 大腿骨近位髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について 多施設共同前向き観察研究

  大江 啓介, 新倉 隆宏, 福井 友章, 林 申也, 黒田 良祐, 酒井 良忠

  中部日本整形外科災害外科学会雑誌, Apr. 2022, Japanese, (一社)中部日本整形外科災害外科学会


• 偽関節治療の基礎研究と臨床応用

  新倉 隆宏, 大江 啓介, 福井 友章, 松本 知之, 美舩 泰, 黒田 良祐

  日本整形外科学会雑誌, Mar. 2022, Japanese, (公社)日本整形外科学会


• 非定型大腿骨骨折の病態と治療 非定型大腿骨骨折の病態と疫学

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  日本整形外科学会雑誌, Mar. 2022, Japanese, (公社)日本整形外科学会


• 小児整形外科疾患に対する新しい治療法-その展望および問題点- 先天性下腿偽関節症に対するMasquelet法を用いた治療経験

  坂田 亮介, 新倉 隆宏, 薩摩 眞一, 小林 大介, 衣笠 真紀, 八尋 俊輔, 北澤 大也, 福井 友章, 大江 啓介, 黒田 良祐

  日本整形外科学会雑誌, Mar. 2022, Japanese, (公社)日本整形外科学会


• 高齢大腿骨頸部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について 多施設共同前向き観察研究

  大江 啓介, 新倉 隆宏, 福井 友章, 林 申也, 酒井 良忠, 高原 俊介, 岩倉 崇, 角田 雅也, 柴原 克紀, 正田 悦朗, 黒田 良祐

  日本整形外科学会雑誌, Mar. 2022, Japanese, (公社)日本整形外科学会


• 患者立脚型機能評価を用いた上肢偽関節の治療成績の検討

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  日本整形外科学会雑誌, Mar. 2022, Japanese, (公社)日本整形外科学会


• CT有限要素法を用いたreamer irrigator aspirator施行前後の大腿骨強度変化についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 長宗 高樹, 黒田 良祐

  日本整形外科学会雑誌, Mar. 2022, Japanese, (公社)日本整形外科学会


• 難治性骨折に対する自家CD34陽節細胞移植 医師主導治験の成果報告

  新倉 隆宏, 大江 啓介, 福井 友章, 松本 知之, 美舩 泰, 川本 篤彦, 黒田 良祐

  日本整形外科学会雑誌, Mar. 2022, Japanese, (公社)日本整形外科学会


• Relationship between proximal femoral morphology and bone mineral density around the stem in patients with femoral neck fracture: A multicenter prospective cohort study

  Keisuke Oe

  Orthopaedic Research Society 2022 Annual Meeting, Feb. 2022, English

  Poster presentation


• 寛骨臼転移性腫瘍に対して病巣搔爬後に内固定および骨セメント充填を行った3例

  大江啓介

  第16回兵庫転移性骨腫瘍治療研究会, Feb. 2022, Japanese

  Oral presentation


• 超音波骨折治療器使用における患者コンプライアンス向上の工夫

  大江啓介

  第25回超音波骨折治療研究会, Jan. 2022, Japanese

  [Invited]

  Public discourse


• Masquelet法の根幹をなすinduced membraneについての組織学的研究

  大江啓介, 新倉隆宏, 福井友章, 黒田良祐

  第36回日本整形外科学会基礎学術集会, Oct. 2021, Japanese

  [Invited]

  Nominated symposium


• 222nm UVCのヒトに対する安全性と有効性

  新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  日本環境感染学会総会プログラム・抄録集, Sep. 2021, Japanese, (一社)日本環境感染学会


• 糖尿病性骨症の病態と臨床疫学 整形外科から見た糖尿病患者の骨折とそのマネジメント

  新倉 隆宏, 西本 華子, 大江 啓介, 福井 友章, 黒田 良祐

  日本骨粗鬆症学会雑誌, Sep. 2021, Japanese, (一社)日本骨粗鬆症学会


• Klippel-Trenaunay症候群の患者に生じた大腿骨感染性偽関節に対する治療経験

  倉科 徹郎, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐

  中部日本整形外科災害外科学会雑誌, Sep. 2021, Japanese, (一社)中部日本整形外科災害外科学会


• 難治骨折の診断と治療

  大江啓介

  兵庫県整形外科医会 骨関節フォーラム, Aug. 2021, Japanese

  [Invited]

  Public discourse


• 偽関節、感染性偽関節の基礎研究と臨床応用 偽関節患者への自家末梢血CD34陽性細胞移植

  大江 啓介, 新倉 隆宏, 福井 友章, 美舩 泰, 松本 知之, 黒田 良祐

  日本整形外科学会雑誌, Aug. 2021, Japanese, (公社)日本整形外科学会


• 偽関節、感染性偽関節の基礎研究と臨床応用 Masquelet法の根幹をなすinduced membraneについての組織学的研究

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  日本整形外科学会雑誌, Aug. 2021, Japanese, (公社)日本整形外科学会


• ヒトinduced membraneにおけるbone morphogenetic proteins(BMP)発現の検討

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 高瀬 恭平, 黒田 良祐

  日本整形外科学会雑誌, Aug. 2021, Japanese, (公社)日本整形外科学会


• 有限要素法を用いたReamer Irrigator Aspirator施行前後の大腿骨強度評価の検討

  大江啓介

  第47回日本骨折治療学会学術集会, Jul. 2021, Japanese

  Oral presentation


• The pathophysiology of;peri;rosthetic atypical femoral fracture

  大江啓介

  第47回日本骨折治療学会学術集会, Jul. 2021, English

  [Invited]

  Nominated symposium


• トップアスリートの外傷・障害とその治療

  黒田 良祐, 大江 啓介, 福井 友章, 新倉 隆宏

  骨折, Jul. 2021, Japanese, (一社)日本骨折治療学会


• AFFの治療 インプラント周囲に発生した非定型大腿骨骨折について

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  骨折, Jul. 2021, Japanese, (一社)日本骨折治療学会


• 治療に難渋する骨折 偽関節に対する低出力超音波パルス療法の有効性

  李 相亮, 川崎 恵吉, 稲垣 克記, 福井 友章, 大江 啓介, 新倉 隆宏

  骨折, Jul. 2021, Japanese, (一社)日本骨折治療学会


• 治療に難渋する骨折 偽関節治療への新たなアプローチ

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  骨折, Jul. 2021, Japanese, (一社)日本骨折治療学会


• 骨修飾薬使用中の悪性腫瘍骨転移患者に発生した非定型大腿骨骨折の治療経過に関する多施設共同研究

  福井 友章, 新倉 隆宏, 大江 啓介, 高原 俊介, 櫻井 敦志, 岩倉 崇, 正田 悦朗, 吉田 圭二, 伊藤 研二郎, 平中 崇文, 角田 雅也, 黒田 良祐

  骨折, Jul. 2021, Japanese, (一社)日本骨折治療学会


• 難治骨折診療の立場からみた大腿骨近位部骨折

  大江啓介

  第14回姫路骨折治療セミナー, Jun. 2021, Japanese

  [Invited]

  Public discourse


• 体外衝撃波療法は閉経後の骨粗鬆症を改善する

  井上 翔太, 脇本 祥夫, 李 昌欣, 畠山 隼平, 新倉 隆宏, 大江 啓介, 福井 友章, 黒木 裕士, 森山 英樹

  理学療法学, Mar. 2021, Japanese, (公社)日本理学療法士協会


• 非感染性偽関節に対する骨SPECTの定量評価(Quantitative evaluation of bone SPECT for uninfected nonunion)

  曽 菲比, 大江 啓介, 野上 宗伸, 犬養 純子, 立花 美保, 久保 和広, 福井 友章, 新倉 隆宏, 黒田 良祐, 村上 卓道

  核医学, 2021, English, (一社)日本核医学会


• 寛骨臼の転移性骨腫瘍に対して骨セメント充填およびスクリューによる内固定を行った2例

  葛原 慎, 原 仁美, 竹森 俊幸, 大江 啓介, 秋末 敏宏, 黒田 良祐

  中部日本整形外科災害外科学会雑誌, Jan. 2021, Japanese, (一社)中部日本整形外科災害外科学会, 症例1(73歳男性)。甲状腺濾胞癌による右寛骨臼転移性腫瘍に対し病巣掻爬+スクリュー内固定+骨セメント充填が行なわれた。その結果、術後2日目から歩行器歩行が可能となり、術後7ヵ月経過現在、右股関節痛なく独歩可能である。症例2(46歳女性)。乳癌による左寛骨臼・大腿骨転移性骨腫瘍に対し病巣掻爬+スクリュー内固定+骨セメント充填が行なわれ、あわせて左大腿骨骨幹部転移性骨腫瘍に対し髄内釘による内固定を同時に施行した。その結果、術後13日目より平行棒内歩行が可能となり、術後8ヵ月経過現在、疼痛なく杖歩行可能である。


• 大腿骨近位部骨折の診断と治療

  大江啓介

  人工骨頭集中講座 in West Japan, Dec. 2020, Japanese

  [Invited]

  Public discourse


• 寛骨臼の転移性骨腫瘍に対して骨セメント充填及びスクリューによる内固定を行った2例

  葛原 慎, 河本 旭哉, 竹森 俊幸, 大江 啓介, 秋末 敏宏, 黒田 良祐

  中部日本整形外科災害外科学会雑誌, Oct. 2020, Japanese, (一社)中部日本整形外科災害外科学会


• 卵巣摘出ラット骨粗鬆症モデルにおける炭酸ガス経皮吸収による骨粗鬆症改善効果の検討

  澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 吉川 遼, 小田 崇弘, 隈部 洋平, 黒田 良祐

  日本整形外科学会雑誌, Sep. 2020, Japanese, (公社)日本整形外科学会


• ウサギを用いた222nm紫外線術野照射の安全性の検討

  福井 友章, 新倉 隆宏, 小田 崇弘, 隈部 洋平, 大江 啓介, 黒田 良祐

  日本整形外科学会雑誌, Sep. 2020, Japanese, (公社)日本整形外科学会


• 炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおける骨折治癒を促進させる

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 隈部 洋平, 澤内 健一, 吉川 遼, 酒井 良忠, 黒田 良祐

  日本整形外科学会雑誌, Sep. 2020, Japanese, (公社)日本整形外科学会


• 骨折治癒過程を超音波の周波数特性により推定する試み

  大江 啓介, 隈部 洋平, 新倉 隆宏, 福井 友章, 黒田 良祐, 畑 豊, 森本 雅和, 八木 直美, 小矢 美晴

  日本整形外科学会雑誌, Sep. 2020, Japanese, (公社)日本整形外科学会


• 男性骨粗鬆症モデルラットに対する炭酸ガス経皮吸収の影響に関する検討

  吉川 遼, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 小田 崇弘, 隈部 洋平, 酒井 良忠, 黒田 良祐

  日本整形外科学会雑誌, Sep. 2020, Japanese, (公社)日本整形外科学会


• 炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる-臨床試験の報告-

  新倉隆宏, 岩倉崇, 李相亮, 大江啓介, 福井友章, 酒井良忠, 秋末敏宏, 黒田良祐

  日本整形外科学会雑誌, 2020, Japanese, (公社)日本整形外科学会


• 創外固定の基礎

  大江 啓介

  第15回 神戸整形外科外傷セミナー, Aug. 2019, Japanese, Domestic conference

  [Invited]


• 大腿骨頚部骨折の術後CT画像評価方法の検討

  大江 啓介

  第45回日本骨折治療学会, Jun. 2019, Japanese, Domestic conference

  Oral presentation


• Masquelet法で治療した患者におけるinduced membraneの組織学的評価

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  骨折, Jun. 2019, Japanese, (一社)日本骨折治療学会


• 下肢長管骨偽関節に対するロッキングプレートを用いた手術の治療成績

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  骨折, Jun. 2019, Japanese, (一社)日本骨折治療学会


• 文書を用いた患者説明によるLIPUSコンプライアンス向上の効果

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  骨折, Jun. 2019, Japanese, (一社)日本骨折治療学会


• 大腿骨頸部骨折の術後CT画像評価方法の検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐, 岩倉 崇, 櫻井 敦志

  骨折, Jun. 2019, Japanese, (一社)日本骨折治療学会


• Periprosthetic femoral fracture with characteristics of atypical femoral fracture -A case report-

  OE Keisuke

  第16回 ORS ISFR2018, Nov. 2018, English, International conference


• Clinical experience of using Reamer-Irrigator-Aspirator system for Japanese patients

  OE Keisuke

  第16回 ORS ISFR2018, Nov. 2018, English, International conference

  Oral presentation


• Minimally invasive plate osteosynthesis for the treatment of humeral shaft

  OE Keisuke

  ORS ISFR2018, Nov. 2018, English, International conference

  Oral presentation


• 偽関節になる経緯と、その後の治療

  大江 啓介

  若手整形外科のための”ここだけはおさえておこう”髄内釘セミナー～下腿のアドバンスコース～, Nov. 2018, Japanese, Domestic conference

  [Invited]

  Public discourse


• 偽関節症例から大腿骨骨幹部骨折を考える

  大江 啓介

  Lower Extremities Trauma Seminar in 博多, Nov. 2018, Japanese, Domestic conference

  [Invited]

  Public discourse


• 炭酸ガス経皮吸収がラットの筋組織に及ぼす影響

  大江 啓介

  第33回日本整形外科学会基礎学術集会, Oct. 2018, Japanese, Domestic conference

  [Invited]

  Nominated symposium


• 創外固定の基礎

  大江 啓介

  第13回神戸整形外科セミナー Basic, Aug. 2018, Japanese, Domestic conference

  [Invited]

  Public discourse


• 炭酸ガス経皮吸収が筋肉に及ぼす影響

  大江 啓介

  第1回炭酸ガス研究会運動器分科会, Jul. 2018, Japanese, Domestic conference

  [Invited]

  Public discourse


• 日本人におけるReamerirrigatoraspirator(RIA)の使用経験

  大江 啓介

  第44回日本骨折治療学会, Jul. 2018, Japanese, Domestic conference

  Oral presentation


• 難治性骨折患者を対象とした自家末梢血CD34陽性細胞移植療法 ―医師主導治験の経験からー

  Kuroda Ryosuke, 福井 友章, Niikura Takahiro, Matsumoto Tomoyuki

  The 17th Congress of the Japanese Society for Regenerative Medicine, Mar. 2018, Japanese, The Japanese Society for Regenerative Medicine, 横浜, Domestic conference

  [Invited]

  Public symposium


• 骨延長術における炭酸ガス経皮吸収の骨形成促進効果について

  隈部 洋平, Niikura Takahiro, 福井 友章, 高原 俊介, 新倉 路生, 黒岩 祐, 小田 崇弘, Kuroda Ryosuke

  The 17th Congress of the Japanese Society for Regenerative Medicine, Mar. 2018, Japanese, The Japanese Society for Regenerative Medicine, 横浜, Domestic conference

  [Invited]

  Poster presentation


• 上腕骨骨幹部偽関節術後偽関節に対してMIPO法にて治療した2例

  栖田 慶仁, 福井 友章, Kuroda Ryosuke, Niikura Takahiro

  第451回整形外科集談会京阪神地方会, Feb. 2018, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 大阪, 【はじめに】上腕骨骨幹部骨折治療後の偽関節の発生は10‐20％と報告があり、上腕骨骨幹部偽関節の治療法については自家骨移植と圧迫プレート固定が一般的とされている。今回われわれは上腕骨骨幹部骨折術後の偽関節に対しMIPO法にて手術を行い、骨癒合が得られた2症例について報告する。【症例1】17歳女性。2012年X月、交通事故で左上腕骨骨幹部骨折(AO分類12-B2)を受傷。近医にて髄内釘固定を受けた。術後1年の時点で骨癒合が得られず偽関節として当院紹介となった。治療は髄内釘抜去後にSynthes社製LCP narrow plateを用いて前方進入のMIPO法で固定術を行った。骨癒合が得られ、術後1年で抜釘術を施行した。術後4年現在可動域制限や疼痛はなくADLに支障はない。【症例2】75歳女性。2014年X月、転倒し右上腕骨骨幹部骨折(AO分類12-A3), Domestic conference

  [Invited]

  Oral presentation


• Improving Patient Compliance with Low-Intensity Pulsed Ultrasound (LIPUS) Treatment (Second Report)

  福井 友章, Kuroda Ryosuke, Niikura Takahiro

  The 21th The Japanese Research Society of Ultrasound Stimultion for Fracuture Repair, Jan. 2018, Japanese, The Japanese Research Society of Ultrasound Stimulation for Fracture Repair, 東京, [Objective]To obtain a therapeutic effect, appropriate use of low-intensity pulsed ultrasound (LIPUS) is necessary and patient compliance is very important for that. We reported at this meeting in 2014 that explanation for patients using leaflets was usef, Domestic conference

  [Invited]

  Oral presentation


• 各ネイルの特徴、DTD使用時の注意点

  大江 啓介

  若手整形外科のための大腿骨髄内釘セミナー －Distal Target Deviceの有用性－, Nov. 2017, Japanese, Stryker Japan, 神戸, Domestic conference

  Oral presentation


• 大腿骨近位部骨折を起こした高齢者におけるビタミンD充足度の調査

  Niikura Takahiro, 岩倉 崇, 李 相亮, 福井 友章, 櫻井 敦志, Sakai Yoshitada, Kuroda Ryosuke

  The 19th Annual Meeting of Japan Osteoporosis Society, Oct. 2017, Japanese, Japan Osteoporosis Society, 大阪, Domestic conference

  [Invited]

  Oral presentation


• Altered Expression of MicroRNAs during Fracture Healing in Diabetic Rats

  高原 俊介, 李 相亮, Niikura Takahiro, 福井 友章, 新倉 路生, 黒岩 祐, 隈部 洋平, Sakai Yoshitada, Kuroda Ryosuke

  The 32nd Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2017, Japanese, The Japanese Orthopaedic Association, 沖縄（宜野湾）, 目的】microRNA (miRNA)は約22塩基長のnon-coding RNAであり、様々な疾患へ関与しており、近年では骨折治癒過程に与える影響も報告されている。糖尿病は骨折治癒を遷延させることが知られているが、その機序におけるmiRNAの関与は明らかではない。我々は糖尿病におけるmiRNAの発現の健常との差異が骨折治癒遷延に関与していると仮説を立て、1型糖尿病ラットの骨折モデルを用いてmiRNAの網羅的解析を行い、その発現様式を検討した。【方法】Streptozotocinを腹腔内投与し1型糖尿病を発症させたSDラット（DM群）と、健常ラット（対照群）を用い、大腿骨閉鎖性骨折モデルを作製した。骨折後5日目および11日目に骨折部から採取したmiRNAに対し、マイクロアレイ解析を行い、対照群に対しDM群で発現の高いmiRNAを、両日につき上位4種ず, Domestic conference

  [Invited]

  Poster presentation


• 骨折治癒の非破壊的評価法について

  大江啓介

  The 9th AMEC Research Seminar, Oct. 2017, Japanese, Advance Medical Engineering Center , Graduate School of Engineering University of Hyogo, 神戸, Domestic conference

  Oral presentation


• 骨形成不全症に合併した上腕骨骨幹部偽関節に対して下顎骨用locking plateを用いて治療した1例

  佐野 翔平, Niikura Takahiro, 福井 友章, Kuroda Ryosuke

  The 129ｔｈ Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Oct. 2017, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 富山, 【はじめに】骨形成不全症は骨脆弱性のため骨折を起こしやすい結合組織の遺伝的な障害である。骨質が乏しいため骨折を生じやすく、また、治療に難渋し偽関節となることが多い。我々は骨形成不全症患者の上腕骨骨幹部偽関節に対し下顎骨用locking plateを用いて骨癒合が得られた症例を経験したので報告する。【症例】骨形成不全症III型の30歳男性。1996年に右上腕骨矯正骨切り術を受けた。2010年に右上腕に疼痛の増強を感じ、X線でK-wireの折損と右上腕骨骨幹部に偽関節を認めた。2011年に当院紹介されエンダー釘による内固定と自家骨移植を行った。しかし、その後も骨癒合が得られず術後2年でエンダー釘が折損し疼痛と可動域制限を生じた。2014年に骨幹部内側に下顎骨用locking plateを用い内固定を行った。半年後、骨癒合が得られ日常生活に支障がない可動域, Domestic conference

  [Invited]

  Oral presentation


• Transcutaneous CO₂ application accelerates bone formation in a rat bone defect model

  黒岩 祐, Niikura Takahiro, 高原 俊介, 李 相亮, 岩倉 崇, 福井 友章, 新倉 路生, 隈部 洋平, Sakai Yoshitada, Kuroda Ryosuke

  The 32nd Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2017, Japanese, The Japanese Orthopaedic Association, 沖縄（宜野湾）, 【目的】骨腫瘍，骨髄炎，外傷などの治療で骨欠損が生じることがあるが，骨欠損に対して臨床応用可能な治療法の選択肢は限られている．我々は以前，ラット骨折モデルにおいてCO₂経皮吸収が血流促進を介して骨癒合を促進することを報告した．しかし骨欠損に対するCO₂経皮吸収の効果は明らかでない．本研究の目的は，ラット骨欠損モデルにおけるCO₂経皮吸収による骨形成促進効果を明らかにすることである．【方法】12週齢Fischerラットの大腿骨に創外固定器を装着し，骨幹部に1mmの骨欠損を作製した．CO₂経皮吸収は，ラットの骨欠損肢を剃毛した上でハイドロジェルを塗布し，下半身を密閉した空間に100 % CO₂を充満させて行った．ラットを2群に分け，CO₂群にはCO₂経皮吸収を術翌日より1回20分，週5回行い，control群では空気を投与した．単純X線評価では、術後1,, Domestic conference

  Public symposium


• Transcutaneous CO₂ application accelerates bone formation in a rat bone defect model

  小田 崇弘, 黒岩 祐, 高原 俊介, 新倉 路生, 隈部 洋平, 李 相亮, 岩倉 崇, 福井 友章, Sakai Yoshitada, Niikura Takahiro, Kuroda Ryosuke

  The 36th Annual Meeting of the Japanese Society for Transplantation and Tissue Engineering in Musculoskeletal System, Sep. 2017, Japanese, The Japanese Society for Transplantation and Tissue Engineering in Musculoskeletal System, 京都, 【目的】日々の診療において，骨欠損を来たした症例にしばしば遭遇するが，それに対する臨床応用可能な治療法は限られている．我々は以前，ラット骨折モデルにおいてCO₂経皮吸収が血流促進を介して骨癒合を促進することを報告した．しかし骨欠損に対する効果は明らかではない．本研究の目的は，CO₂経皮吸収がラット骨欠損モデルにおいても骨形成促進効果を認めるかどうかを検討することである．【方法】12週齢Fischerラットの大腿骨に創外固定器を装着，骨幹部に1mmの骨欠損を作製した．骨欠損肢を剃毛しハイドロジェルを塗布，下半身を密閉した空間に100 % CO₂を充満させ経皮吸収を行った．CO₂群には術翌日から1回20分，週5回CO₂経皮吸収を行い，control群には空気を投与した．術後1, 2, 3, 4週でX線撮影し，側面像で骨片間にgapがない，あるいは両皮質骨, Domestic conference

  Oral presentation


• 炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる－臨床試験の報告－

  Niikura Takahiro, 岩倉 崇, 李 相亮, 福井 友章, Sakai Yoshitada, Kuroda Ryosuke

  The 43nd Annual Meeting of the Japanese Society for Fracture Repair, Jul. 2017, Japanese, Japanese Society for Fracture Repair, 福島, Topical cutaneous application of carbon dioxide using a hydrogel is a new treatment option to accelerate fracture repair -Results of a clinical trial-, Domestic conference

  [Invited]

  Oral presentation


• Analysis of cases where LIPUS was used following nonunion surgery

  李 相亮, Niikura Takahiro, 福井 友章, Kuroda Ryosuke

  The 43nd Annual Meeting of the Japanese Society for Fracture Repair, Jul. 2017, Japanese, Japanese Society for Fracture Repair, 福島, Domestic conference

  [Invited]

  Oral presentation


• An Evaluation of Force Difference Between Left and Right Difference Around Greater Trochanter Under Pelvic Belt.

  Shimizu Yusuke, Nagamune Kouki, Ooe Keisuke, Sangyang Lee, Niikura Takahiro, Kuroda Ryousuke, Kurosaka Masahiro

  Proceedings of the Fuzzy System Symposium, 2015, Japanese, Japan Society for Fuzzy Theory and Intelligent Informatics, A pelvic belt is a tool of first aid for the pelvic fracture patients . The purpose is to stabilize the unstable pelvis and to control bleeding from arteries and organs inside the pelvis . However, there is no pelvic belt which takes into account for the differences of race and gender, and evaluation during surgery . The purpose of this study is to develop an evaluation system for the pelvic belt and worn to be a person. It will be a basis for the future development of the pelvic band. Especially the pelvic band has a risk of decubitus where the pelvic band fixes the major trochanter strongly. Naturally, load generated between the body and pelvic belt is large, because it is required to fix the pelvic fracture. Therefore, we evaluate the distribution and load generated between the body and pelvis belt .