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UEHARA Keiichiro
University Hospital / Diagnostic Pathology
Associate Professor

Researcher basic information

■ Research Areas
  • Life sciences / Human pathology

Research activity information

■ Paper
  • Katsuya Sato, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Yosuke Yamashita, Masakazu Shinohara, Suji Lee, Anika Reinhardt, Knut Woltjen, Koji Chiba, Hideaki Miyake, Masato Fujisawa, Takashi Aoi
    Late-onset hypogonadism (LOH) syndrome is characterized by age-related testosterone deficiency and negatively affects the quality of life of older men. A promising therapeutic approach for LOH syndrome is transplantation of testosterone-producing Leydig-like cells (LLCs) derived from human induced pluripotent stem cells (hiPSCs). However, previous studies have encountered obstacles, such as limited cell longevity, insufficient testosterone production, and inefficiency of differentiation. To address these issues, we developed a novel protocol that includes forced NR5A1 expression, a cytokine cocktail promoting mesoderm differentiation, and a transitional shift from 3D to 2D cultures. The resultant cells survived on culture dishes for over 16 weeks, produced 22-fold more testosterone than the conventional method, and constituted a homogeneous population of LLCs with a differentiation efficiency exceeding 99% without purification. Furthermore, these LLCs were successfully engrafted subcutaneously into mice, resulting in increased serum testosterone levels. Our study will facilitate innovative therapeutic strategies for LOH syndrome.
    Jan. 2025, Stem cell reports, 102392 - 102392, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takuto Hara, Junya Furukawa, Takahiro Tsutiya, Takayuki Kodama, Keiichiro Uehara, Tomoaki Terakawa, Kenichi Harada, Jun Teishima, Yuzo Nakano, Masato Fujisawa
    INTRODUCTION: Renal cell carcinoma with an inferior vena cava tumor thrombus is a challenging disease that requires a multimodal treatment approach. Pembrolizumab plus lenvatinib has displayed promising efficacy in metastatic renal cell carcinoma. CASE PRESENTATION: A 61-year-old man was diagnosed with metastatic renal cell carcinoma and a tumor thrombus adhering to the inferior vena cava wall by cine magnetic resonance imaging. After 6 months of pembrolizumab and lenvatinib therapy, tumor shrinkage was detected, excluding the advanced portion of the inferior vena cava thrombus, and nephrectomy and thrombectomy were performed. Adhesion of the tumor thrombus to the inferior vena cava wall was observed during surgery. Resection produced a remarkable pathological complete response with no viable cells in the resected specimens, including the thrombus site. CONCLUSION: This case highlights the potential of pembrolizumab plus lenvatinib for treating advanced renal cell carcinoma with an inferior vena cava thrombus and the utility of cine magnetic resonance imaging for evaluating thrombus adhesion to the inferior vena cava.
    Jan. 2024, IJU case reports, 7(1) (1), 60 - 63, English, International magazine
    Link to Kobe Univ. Repository (Kernel)

  • Kohei Yamakawa, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Atsuhiro Masuda, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto, Yuzo Kodama, Takashi Aoi
    Objectives Small proline-rich protein 1A (SPRR1A) is recognized as a squamous differentiation marker but is also upregulated in some non-squamous cancers. However, its expression in pancreatic ductal adenocarcinoma (PDAC) has not been investigated. This study elucidated the expression of SPRR1A in PDAC and its effect on the prognosis and malignant behavior of PDAC. Methods We examined the SPRR1A expression by immunohistochemistry in 86 surgical PDAC cases and revealed the relationship between its expression and the prognosis of the PDAC patients. Furthermore, we overexpressed SPRR1A in pancreatic cancer cell lines (PK-1 and Panc-1) and assessed the phenotype and gene expression changes in vitro. Results Among the 84 cases, excluding 2 with squamous differentiation, 31 (36.9%) had a high SPRR1A expression. The overall survival (median 22.1 months vs. 33.6 months, p = 0.0357) and recurrence-free survival (median 10.7 months vs. 15.5 months, p = 0.0298) were significantly lower in the high-SPRR1A-expression group than in the low-SPRR1A-expression group. A multivariate analysis indicated that a high SPRR1A expression (HR 1.706, 95% CI 1.018 to 2.862, p = 0.0427) and residual tumor status (HR 2.687, 95% CI 1.487 to 4.855, p = 0.00106) were independent prognostic factors. The analysis of TCGA transcriptome data demonstrated that the high-SPRR1A-expression group had a significantly worse prognosis than the low-SPRR1A-expression group, which supported our data. SPRR1A overexpression in PK-1 and Panc-1 did not result in remarkable changes to in vitro phenotypes, such as the cell proliferation, chemo-resistance, EMT, migration or global gene expression. Conclusion Increased expression of SPRR1A is associated with a poor prognosis in PDAC and may serve as a novel prognostic marker. However, our in vitro study suggests that the SPRR1A expression may be a consequence, not a cause, of the aggressive behavior of PDAC.
    Public Library of Science (PLoS), May 2022, PLOS ONE, 17(5) (5), e0266620 - e0266620, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takahiro Koide, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Yoshihiro Kakeji, Takashi Aoi
    Intestinal metaplasia is related to gastric carcinogenesis. Previous studies have suggested the important role of CDX2 in intestinal metaplasia, and several reports have shown that the overexpression of CDX2 in mouse gastric mucosa caused intestinal metaplasia. However, no study has examined the induction of intestinal metaplasia using human gastric mucosa. In the present study, to produce an intestinal metaplasia model in human gastric mucosa in vitro, we differentiated human-induced pluripotent stem cells (hiPSC) to gastric organoids, followed by the overexpression of CDX2 using a tet-on system. The overexpression of CDX2 induced, although not completely, intestinal phenotypes and the enhanced expression of many, but not all, intestinal genes and previously reported intestinal metaplasia-related genes in the gastric organoids. This model can help clarify the mechanisms underlying intestinal metaplasia and carcinogenesis in human gastric mucosa and develop therapies to restitute precursor conditions of gastric cancer to normal mucosa.
    May 2022, iScience, 25(5) (5), 104314 - 104314, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Keiichiro Uehara, Michiyo Koyanagi-Aoi, Takahiro Koide, Tomoo Itoh, Takashi Aoi
    Human gastric development has not been well studied. The generation of human pluripotent stem cell-derived gastric organoids (hGOs) comprising gastric marker-expressing epithelium without an apparent smooth muscle (SM) structure has been reported. We modified previously reported protocols to generate hGOs with muscularis mucosa (MM) from hiPSCs. Time course analyses revealed that epithelium development occurred prior to MM formation. Sonic hedgehog (SHH) and TGF-β1 were secreted by the epithelium. HH and TGF-β signal inhibition prevented subepithelial MM formation. A mechanical property of the substrate promoted SM differentiation around hGOs in the presence of TGF-β. TGF-β signaling was shown to influence the HH signaling and mechanical properties. In addition, clinical specimen findings suggested the involvement of TGF-β signaling in MM formation in recovering gastric ulcers. HH and TGF-β signaling from the epithelium to the stroma and the mechanical properties of the subepithelial environment may influence the emergence of MM in human stomach tissue.
    Apr. 2022, Stem cell reports, 17(4) (4), 820 - 834, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takaki Ishida, Michiyo Koyanagi-Aoi, Daisuke Yamamiya, Atsushi Onishi, Katsuya Sato, Keiichiro Uehara, Masato Fujisawa, Takashi Aoi
    Late-onset hypogonadism (LOH) syndrome, due to a partial lack of testosterone, decreases the quality of life of older men. Testosterone is mainly secreted by Leydig cells in the testes. Leydig cell transplantation is expected to be a promising alternative to conventional testosterone replacement therapy for LOH syndrome. We herein report a simple and robust protocol for directed differentiation of human induced pluripotent stem cells (hiPSCs) into Leydig-like cells by doxycycline-inducible overexpression of NR5A1 and treatment with a combination of 8-bromoadenosine-3',5'-cyclic monophosphate (8-Br-cAMP) and forskolin. The differentiated cells expressed the steroidogenic enzyme genes STAR, CYP11A1, CYP17A1, and HSD3B2 and the specific markers of adult Leydig cells HSD17B3, INSL3, and LHCGR. Furthermore, we confirmed the secretion of functional testosterone from the cells into the culture supernatant by a testosterone-sensitive cell proliferation assay. These findings showed that the hiPSCs were able to be differentiated into Leydig-like cells, supporting the expectation that hiPSC-derived Leydig-like cells can be novel tools for treating LOH syndrome.
    Dec. 2021, Endocrinology, 162(12) (12), English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 脾EBウイルス関連炎症性偽腫瘍が考えられた一例
    中西 亨明, 神保 直江, 上原 慶一郎, 伊藤 智雄
    (一社)日本病理学会, Mar. 2021, 日本病理学会会誌, 110(1) (1), 360 - 360, Japanese

  • Yasufumi Koterazawa, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Yoshihiro Kakeji, Takashi Aoi
    In the original publication of the article, the following errors were noted and corrected in this correction.
    Oct. 2020, Journal of gastroenterology, 55(10) (10), 1010 - 1011, English, Domestic magazine

  • Yasufumi Koterazawa, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Yoshihiro Kakeji, Takashi Aoi
    BACKGROUND: The esophagus is known to be derived from the foregut. However, the mechanisms regulating this process remain unclear. In particular, the details of the human esophagus itself have been poorly researched. In this decade, studies using human induced pluripotent stem cells (hiPSCs) have proven powerful tools for clarifying the developmental biology of various human organs. Several studies using hiPSCs have demonstrated that retinoic acid (RA) signaling promotes the differentiation of foregut into tissues such as lung and pancreas. However, the effect of RA signaling on the differentiation of foregut into esophagus remains unclear. METHODS: We established a novel stepwise protocol with transwell culture and an air-liquid interface system for esophageal epithelial cell (EEC) differentiation from hiPSCs. We then evaluated the effect of all-trans retinoic acid (ATRA), which is a retinoic acid receptor (RAR)α, RARβ and RARγ agonist, on the differentiation from the hiPSC-derived foregut. Finally, to identify which RAR subtype was involved in the differentiation, we used synthetic agonists and antagonists of RARα and RARγ, which are known to be expressed in esophagus. RESULTS: We successfully generated stratified layers of cells expressing EEC marker genes that were positive for lugol staining. The enhancing effect of ATRA on EEC differentiation was clearly demonstrated with quantitative reverse transcription polymerase chain reaction, immunohistology, lugol-staining and RNA sequencing analyses. RARγ agonist and antagonist enhanced and suppressed EEC differentiation, respectively. RARα agonist had no effect on the differentiation. CONCLUSION: We revealed that RARγ activation promotes the differentiation of hiPSCs-derived foregut into EECs.
    Aug. 2020, Journal of gastroenterology, 55(8) (8), 763 - 774, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Kotaro Suzuki, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Nobuyuki Hinata, Masato Fujisawa, Takashi Aoi
    For augmentation or reconstruction of urinary bladder after cystectomy, bladder urothelium derived from human induced pluripotent stem cells (hiPSCs) has recently received focus. However, previous studies have only shown the emergence of cells expressing some urothelial markers among derivatives of hiPSCs, and no report has demonstrated the stratified structure, which is a particularly important attribute of the barrier function of mature bladder urothelium. In present study, we developed a method for the directed differentiation of hiPSCs into mature stratified bladder urothelium. The caudal hindgut, from which the bladder urothelium develops, was predominantly induced via the high-dose administration of CHIR99021 during definitive endoderm induction, and this treatment subsequently increased the expressions of uroplakins. Terminal differentiation, characterized by the increased expression of uroplakins, CK13, and CK20, was induced with the combination of Troglitazone + PD153035. FGF10 enhanced the expression of uroplakins and the stratification of the epithelium, and the transwell culture system further enhanced such stratification. Furthermore, the barrier function of our urothelium was demonstrated by a permeability assay using FITC-dextran. According to an immunohistological analysis, the stratified uroplakin II-positive epithelium was observed in the transwells. This method might be useful in the field of regenerative medicine of the bladder.
    Jul. 2019, Scientific reports, 9(1) (1), 10506 - 10506, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Kotaro Suzuki, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Nobuyuki Hinata, Takashi Aoi, Masato Fujisawa
    Apr. 2019, Journal of Urology, English
    [Refereed]
    Scientific journal

  • 心筋炎を発症した心筋組織に浸潤するマクロファージの免疫組織化学的評価
    中嶋 七海, 西尾 真理, 吉田 誠, 上原 慶一郎, 田中 秀和, 児玉 貴之, 小平 日実子, 重岡 学, 狛 雄一朗, 横崎 宏
    (一社)日本病理学会, Apr. 2019, 日本病理学会会誌, 108(1) (1), 449 - 449, Japanese

  • Kotaro Suzuki, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Nobuyuki Hinata, Takashi Aoi, Masato Fujisawa
    Springer Science and Business Media {LLC}, Mar. 2019, European Urology Supplements, 18(1) (1), e1763, English
    [Refereed]
    Scientific journal

  • Okuni M, Yakushijin Kimikazu, Uehara Keiichiro, Ichikawa H, Suto H, Hashimoto A, Tanaka Y, Shinzato I, Sakai R, Mizutani Y, Nagao S, Kurata K, Kakiuchi S, Miyata Y, Inui Y, Saito Y, Kawamoto Shinichiro, Yamamoto K, Ito Mitsuhiro, Matsuoka Hiroshi, Minami Hironobu
    A 45-year-old woman was diagnosed with hepatosplenic T-cell lymphoma (HSTCL), a rare subtype of peripheral T-cell lymphoma. She received different types of chemotherapy, but disease progression was observed. To reduce the tumor burden before an unrelated bone marrow transplantation, combination chemotherapy consisting of the gemcitabine, carboplatin, and dexamethasone (GCD) was administered as bridging therapy, resulting in a reduction in the number of lymphoma cells. We were then able to perform bone marrow transplantation. Although she experienced some adverse events, she successfully achieved long-term remission. We herein report a successful case of HSTCL treated with unrelated stem cell transplantation following the GCD regimen as bridging chemotherapy.
    Mar. 2019, Intern Med., 58(5) (5), 707 - 712, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Ogawa H, Tanaka Yugo, Tachihara Motoko, Uehara Keiichiro, Shimizu Nahoko, Doi T, Hokka Daisuke, Maniwa Yoshimasa
    ROS proto-oncogene 1 receptor tyrosine kinase (ROS1)-rearranged lung cancer is rare and comprises only 1% of lung adenocarcinoma cases. It has recently been reported to have good response to crizotinib, a tyrosine kinase inhibitor of anaplastic lymphoma kinase. Driver oncogene mutations with approved therapies seldom coexist with a high expression of Programmed death-ligand 1 (PD-L1). The present case report describes a rare case of ROS1 rearrangement with high-PD-L1-expressing occult lung adenocarcinoma. A 32-year-old woman presented with chest pain and a prolonged cough. Chest computed tomography (CT) revealed a 57×36-mm tumor in the mediastinum, with no tumors detected in other regions. Positron emission tomography (PET)-CT showed a strong fluorodeoxyglucose accumulation in the tumor (SUVmax 13.2). Mediastinal tumor resection was completely resected using a video-assisted thoracic surgery approach. Pathological examination showed the tumor cells were positive for thyroid transcription factor 1, Napsin-A, ROS1, and PD-L1 (tumor proportion score >99%). ROS1 rearrangement was confirmed by fluorescence in situ hybridization. The mediastinal tumor was diagnosed as mediastinal lymph node metastasis of ROS1-rearranged PD-L1 high-expression undifferentiated lung adenocarcinoma (pathological stage 3, TxN2M0). Two months after the operation, the CT scan showed multiple mediastinum lymph nodes metastases with rapid tumor growth. The patient achieved a complete response after three cycles of S-1 plus cisplatin with concurrent radiotherapy 60 Gy/30 Fr.
    Jan. 2019, Oncol Lett, 17(1) (1), 488 - 491, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Keiichiro Uehara, Fumi Kawakami, Takanori Hirose, Hiroki Morita, Eiji Kudo, Masanori Yasuda, Bruno Märkl, Yoh Zen, Tomoo Itoh, Yukihiro Imai
    The clinicopathological and immunohistochemical characteristics of clinically occult extrapulmonary lymphangioleiomyomatosis in lymph nodes (LN-LAM) being dissected during surgical staging of pelvic malignancy have not been well investigated. We assessed samples from nine female patients (median age, 61). None had past or familial history of tuberous sclerosis and had LAM lesions other than LN such as lung. The primary malignancies included four endometrial endometrioid carcinomas, one endometrial carcinosarcoma, three ovarian serous carcinomas and one urothelial carcinoma. Median follow-up was 43 months. The number of affected LNs ranged from 1 to 15 (median, 2) with sizes ranging from 1 to 13 mm (median, 3.0). Six cases had clinically occult LN-LAM only within the pelvic LNs, two only within para-aortic LNs, and one within both pelvic and para-aortic lymph nodes. Immunohistochemically, LAM cells exhibited a strong diffuse positivity for β-catenin and E-cadherin in all nine cases. Clinically occult LN-LAM mainly affects peri- or post-menopausal women. On rare occasions, occult LN-LAM may manifest as systemic LAM, including in the lung. β-catenin and E-cadherin carry potential utility as additional diagnostic markers.
    Jan. 2019, Pathology international, 69(1) (1), 29 - 36, English, International magazine
    [Refereed]
    Scientific journal

  • Yotaro Ochi, Nobuhiro Hiramoto, Tetsuichi Yoshizato, Yuichiro Ono, June Takeda, Yusuke Shiozawa, Kenichi Yoshida, Nobuyuki Kakiuchi, Yuichi Shiraishi, Hiroko Tanaka, Kenichi Chiba, Yasuhiro Kazuma, Sumie Tabata, Noboru Yonetani, Keiichiro Uehara, Daisuke Yamashita, Yukihiro Imai, Koji Nagafuji, Mitsunori Yamakawa, Satoru Miyano, Akifumi Takaori-Kondo, Seishi Ogawa, Takayuki Ishikawa
    Nov. 2018, Haematologica, 103(11) (11), e553-e556 - e556, English, International magazine
    [Refereed]
    Scientific journal

  • 肺腫瘍血栓性微小血管症(PTTM)による呼吸不全のため急激に死の転機をたどった舌下腺腺様嚢胞癌症例
    林 一樹, 篠原 尚吾, 内藤 泰, 藤原 敬三, 末廣 篤, 岸本 逸平, 原田 博之, 桑田 文彦, 山本 亮介, 佐藤 悠城, 上原 慶一郎
    (地独)神戸市民病院機構, Mar. 2018, 神戸市立病院紀要, (56) (56), 71 - 72, Japanese
    [Refereed]

  • Daichi Fujimoto, Yuki Sato, Keiichiro Uehara, Kaori Ishida, Junya Fukuoka, Takeshi Morimoto, Hayato Kawachi, Ryobu Mori, Munehiro Ito, Shunsuke Teraoka, Kazuma Nagata, Atsushi Nakagawa, Kojiro Otsuka, Yukihiro Imai, Keisuke Tomii
    INTRODUCTION: Nivolumab has demonstrated efficacy against metastatic NSCLC. Four programmed cell death ligand 1 (PD-L1) immunohistochemistry (IHC) assay systems are available for identification of responders among patients with NSCLC, and these assays show some differing characteristics. Accordingly, in this study, we evaluated the ability of these assays to identify responders to nivolumab therapy. METHODS: We retrospectively analyzed patients with previously treated advanced NSCLC, who received nivolumab between January 2016 and September 2016. Specimens were stained using four PD-L1 IHC assays (28-8, 22C3, SP142, and SP263). We classified patients as having test results that were strongly positive (tumor proportion score [TPS] ≥50%), weakly positive (TPS 1%-49%), or negative (TPS <1%). RESULTS: A total of 40 patients with NSCLC and their specimens were analyzed. Analytical comparisons demonstrated good concordance of PD-L1-stained tumor cells among the 28-8, 22C3, and SP263 assays (weighted κ coefficient 0.64-0.71), whereas the SP142 assay showed lower concordance with other assays (weighted κ coefficient 0.39-0.55). Progression-free survival in patients showing strongly positive PD-L1 staining classified by 28-8, 22C3, and SP263 assays was significantly longer than that in patients with a negative result for PD-L1 staining. Predictive performance of response to nivolumab, as assessed by receiver operating characteristic analysis, was also equivalent among the 28-8, 22C3, and SP263 assays (area under the curve 0.75-0.82), whereas the SP142 assay exhibited lower predictive performance (area under the curve 0.68). CONCLUSIONS: The 28-8, 22C3, and SP263 PD-L1 IHC assays showed equivalent predictive performance, whereas the SP142 assay showed lower predictive performance.
    Mar. 2018, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 13(3) (3), 377 - 386, English, International magazine
    [Refereed]
    Scientific journal

  • Yoichiro Tohi, Noriyuki Makita, Issei Suzuki, Ryosuke Suzuki, Arinobu Fukunaga, Masashi Kubota, Takashi Matsuoka, Yoshio Sugino, Koji Inoue, Keiichiro Uehara, Yukihiro Imai, Mutsushi Kawakita
    A 61-year-old man with a left renal mass, which was detected by ultrasound during a routine health examination, was referred to our department. The patient had a surgical history of two pneumothorax operations, and the patient's brother also had a history of pneumothorax surgery. A case of Birt-Hogg-Dubé (BHD) syndrome was suspected based on patient history. The pathological diagnosis of the resected tumor, which used robot-assisted laparoscopic partial nephrectomy, was determined to be chromophobe renal cell carcinoma (grade 2, pT1a). BHD syndrome was confirmed by genetic testing, where a nonsense mutation of exon 9 in the FOLLICULIN (FLCN) gene was detected. The patient is currently alive 10 months after surgery.
    泌尿器科紀要刊行会, Mar. 2018, Hinyokika kiyo. Acta urologica Japonica, 64(3) (3), 107 - 110, Japanese, Domestic magazine
    [Refereed]
    Scientific journal

  • Reduced Tumour Proportion Scores for Programmed Cell Death Ligand 1 in Stored Paraffin Tissue Sections.
    YUKI SATO, DAICHI FUJIMOTO, KEIICHIRO UEHARA, HAYATO KAWACHI, KAZUMA NAGATA, ATSUSHI NAKAGAWA, KOJIRO OTSUKA, ICHIRO SAKANOUE, HIROSHI HAMAKAWA, YUTAKA TAKAHASHI, YUKIHIRO IMAI, KEISUKE TOMII
    BACKGROUND/AIM: We evaluated the effects of storage of formalin-fixed, paraffin-embedded (FFPE) sections on the tumour proportion score (TPS) for programmed cell death ligand 1 (PD-L1), as indicator in non-small cell lung cancer (NSCLC) tissues of treatment efficacy. MATERIALS AND METHODS: NSCLC postoperative specimens with PD-L1 TPS ≥50% were obtained and cut into five serial sections. One section was stained immediately, and four were stored at 4°C for 2, 4, 6, or 8 weeks. Slides were subjected to PD-L1 immunohistochemistry using the anti-PD-L1 clone 28-8. PD-L1 TPS were blindly evaluated by two independent pathologists. RESULTS: Twelve specimens (60 slides) were evaluated. After slide storage for 2, 4, 6, and 8 weeks, a TPS of <50% was obtained in five (41%), four (33%), seven (58%), and eight (67%) patients, respectively. CONCLUSION: TPS values for PD-L1 were reduced by long-term slide storage of FFPE specimens. Sectioned slides should be stained for PD-L1 without delay.
    2018, Anticancer Research, 38(3) (3), 1401 - 1405, English, International magazine
    [Refereed]
    Scientific journal

  • Daichi Fujimoto, Yuki Sato, Takeshi Morimoto, Keiichiro Uehara, Munehiro Ito, Kojiro Otsuka, Kazuma Nagata, Ichiro Sakanoue, Hiroshi Hamakawa, Atsushi Nakagawa, Yutaka Takahashi, Yukihiro Imai, Keisuke Tomii
    Elsevier Inc., 2018, Clinical Lung Cancer, English
    [Refereed]
    Scientific journal

  • Shunsuke Teraoka, Daichi Fujimoto, Takeshi Morimoto, Hayato Kawachi, Munehiro Ito, Yuki Sato, Kazuma Nagata, Atsushi Nakagawa, Kojiro Otsuka, Keiichiro Uehara, Yukihiro Imai, Kaori Ishida, Junya Fukuoka, Keisuke Tomii
    Dec. 2017, JOURNAL OF THORACIC ONCOLOGY, 12(12) (12), 1798 - 1805, English
    [Refereed]
    Scientific journal

  • Yuki Sato, Daichi Fujimoto, Takeshi Morimoto, Keiichiro Uehara, Kazuma Nagata, Ichiro Sakanoue, Hiroshi Hamakawa, Yutaka Takahashi, Yukihiro Imai, Keisuke Tomii
    Nov. 2017, RESPIROLOGY, 22(8) (8), 1615 - 1621, English
    [Refereed]
    Scientific journal

  • Daichi Fujimoto, Keiichiro Uehara, Yuki Sato, Ichiro Sakanoue, Munehiro Ito, Shunsuke Teraoka, Kazuma Nagata, Atsushi Nakagawa, Yasuhiro Kosaka, Kojiro Otsuka, Yukihiro Imai, Hiroshi Hamakawa, Yutaka Takahashi, Masaki Kokubo, Keisuke Tomii
    Sep. 2017, SCIENTIFIC REPORTS, 7, English
    [Refereed]
    Scientific journal

  • Basal Cell Carcinoma with Severe Calcification
    中村 文香, 増田 泰之, 鷲見 真由子, 小坂 博志, 小川 真希子, 長野 徹, 上原 慶一郎, 今井 幸弘
    金原出版, Aug. 2017, 皮膚科の臨床, 59(9) (9), 1407 - 1410, Japanese
    [Refereed]
    Scientific journal

  • Jiro Ito, Daichi Fujimoto, Ayaka Nakamura, Tohru Nagano, Keiichiro Uehara, Yukihiro Imai, Keisuke Tomii
    Jul. 2017, LUNG CANCER, 109, 58 - 61, English
    [Refereed]
    Scientific journal

  • Osimertinibが奏効した肺腺癌脈絡膜転移の1例
    河内 勇人, 佐藤 悠城, 藤本 大智, 森 令法, 平林 亮介, 伊藤 宗洋, 中川 嘉宏, 伊藤 次郎, 古郷 摩利子, 寺岡 俊輔, 永田 一真, 中川 淳, 大塚 浩二郎, 籏智 幸政, 富井 啓介, 吉水 聡, 上原 慶一郎, 今井 幸弘
    (NPO)日本肺癌学会, Jun. 2017, 肺癌, 57(3) (3), 242 - 242, Japanese

  • Hayashi Kazuki, Shinohara Shogo, Suehiro Atsushi, Kishimoto Ippei, Harada Hiroyuki, Sato Yuki, Uehara Keiichiro
    JAPAN SOCIETY FOR HEAD AND NECK SURGERY, Jun. 2017, JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY, 27(1) (1), 117 - 121, Japanese
    [Refereed]
    Scientific journal

  • 藤本 大智, 佐藤 悠城, 上原 慶一郎, 森本 剛, 河内 勇人, 森 令法, 平林 亮介, 伊藤 宗洋, 中川 嘉宏, 古郷 摩利子, 寺岡 俊輔, 伊藤 次郎, 永田 一真, 中川 淳, 大塚 浩二郎, 籏智 幸政, 今井 幸弘, 富井 啓介
    (一社)日本呼吸器学会, Mar. 2017, 日本呼吸器学会誌, 6(増刊) (増刊), 122 - 122, Japanese

  • Shogo Shinohara, Shinji Takebayashi, Masahiro Kikuchi, Tetsuhiko Michida, Kazuki Hayashi, Ryosuke Yamamoto, Yukihiro Imai, Keiichiro Uehara, Yu Usami
    Japan Society for Head and Neck Cancer, 2017, Japanese Journal of Head and Neck Cancer, 43(4) (4), 403 - 408, Japanese
    [Refereed]
    Scientific journal

  • 視野障害を契機に診断に至りアファチニブが奏効した肺腺癌脈絡膜転移の1例
    河内 勇人, 佐藤 悠城, 森 令法, 平林 亮介, 伊藤 宗洋, 中川 嘉宏, 伊藤 次郎, 古郷 摩利子, 寺岡 俊輔, 藤本 大智, 永田 一真, 中川 淳, 大塚 浩二郎, 籏智 幸正, 富井 啓介, 吉水 聡, 上原 慶一郎, 今井 幸弘
    (NPO)日本肺癌学会, Dec. 2016, 肺癌, 56(7) (7), 1065 - 1065, Japanese

  • Yuki Sato, Daichi Fujimoto, Keiichiro Uehara, Ryoko Shimizu, Jiro Ito, Mariko Kogo, Shunsuke Teraoka, Ryoji Kato, Kazuma Nagata, Atsushi Nakagawa, Kojiro Otsuka, Hiroshi Hamakawa, Yutaka Takahashi, Yukihiro Imai, Keisuke Tomii
    Nov. 2016, BMC CANCER, 16, English
    [Refereed]
    Scientific journal

  • 消化管粘膜における炭酸ランタン沈着の様式
    Hara Shigeo, 上原慶一郎, 藤森明, 吉本明弘, 今井幸弘, 伊藤智雄
    May 2016, 日本腎臓学会誌, 58(3号) (3号), 313, Japanese
    Research society

  • Kenta Shinozaki, Tetsuo Ajiki, Taku Matsumoto, Sae Murakami, Yuko Yoshida, Taro Okazaki, Takumi Fukumoto, Keiichiro Uehara, Yonson Ku
    Japanese Society of Gastroenterological Surgery, 2016, Japanese Journal of Gastroenterological Surgery, 49(11) (11), 1108 - 1116, Japanese
    [Refereed]
    Scientific journal

  • The prospect of endoscopic submucosal dissection for early anal canal squamous cell carcinoma.
    Takahiko Ito, Shuko Morita, Naoto Shimeno, Keiichiro Uehara, Yukihiro Imai, Tetsuro Inokuma
    2016, Clinical Journal of Gastroenterology, English
    [Refereed]
    Scientific journal

  • ITO Takahiko, INOKUMA Tetsuro, SHIMENO Naoto, TANIGUCHI Yohei, FUKUSHIMA Masashi, WADA Masaya, MORITA Shuko, INOUE Satoko, UEHARA Keiichiro, IMAI Yukihiro
    <p>Anal canal cancer is rarely diagnosed, although colon cancer is more and more frequently diagnosed, and most anal canal cancers are diagnosed at an advanced stage. As to treatment, in Europe and the United States chemoradiation therapy is the standard treatment for adenocarcinoma and squamous cell carcinoma (SCC) ; however, there is no systematic standard therapy for SCC.
    Japan Gastroenterological Endoscopy Society, 2016, GASTROENTEROLOGICAL ENDOSCOPY, 58(9) (9), 1426 - 1431, Japanese
    [Refereed]
    Scientific journal

  • Mariko Kogo, Ryoko Shimizu, Keiichiro Uehara, Yutaka Takahashi, Masaki Kokubo, Yukihiro Imai, Keisuke Tomii
    Nov. 2015, LUNG CANCER, 90(2) (2), 364 - 368, English
    [Refereed]
    Scientific journal

  • 副耳下腺由来が疑われた頬部多形腺腫の1例
    首藤 敦史, 竹信 俊彦, 平井 雄三, 谷池 直樹, 上原 慶一郎, 宇佐美 悠, 大西 正信
    日本病院歯科口腔外科協議会, Jun. 2015, Hospital Dentistry & Oral-Maxillofacial Surgery, 27(1) (1), 29 - 34, Japanese

  • Keiichiro Uehara, Yu Usami, Yukihiro Imai, Michio Shimizu
    Mar. 2015, PATHOLOGY INTERNATIONAL, 65(3) (3), 144 - 147, English
    [Refereed]
    Scientific journal

  • MINAMIDE Tatsunori, UEHARA Keiichiro, FUKUSHIMA Masashi, WADA Masaya, MORITA Syuko, SHIMENO Naoto, INOUE Satoko, TEI Hiroshi, SUGINOSHITA Yoshiki, INOKUMA Tetsuro
    A 92-year-old woman was admitted to our hospital with exertional dyspnea due to anemia. Gastrointestinal bleeding was suspected. Enhanced computed tomography revealed a small lesion in the upper jejunum, which was stained at the arterial phase, and video capsule endoscopy showed bloody fluid in the same region. Double-balloon enteroscopy revealed a reddish protruding lesion of
    Japan Gastroenterological Endoscopy Society, 2015, GASTROENTEROLOGICAL ENDOSCOPY, 57(10) (10), 2448 - 2454, Japanese
    [Refereed]
    Scientific journal

  • Takehito Yamamoto, Akira Miki, Kazuyuki Okada, Chihiro Ichikawa, Ryosuke Matsuoka, Keiichiro Uehara, Satoshi Kaihara, Ryo Hosotani
    Japanese Society of Gastroenterological Surgery, 2015, Japanese Journal of Gastroenterological Surgery, 48(6) (6), 473 - 480, Japanese
    [Refereed]
    Scientific journal

  • 術前に肝原発と診断し得たガストリノーマの1切除例
    木下 裕光, 八木 眞太郎, 阪本 裕亮, 山本 健人, 岡田 和幸, 井ノ口 健太, 姚 思遠, 三木 明, 近藤 正人, 瓜生原 健嗣, 橋田 裕毅, 小林 裕之, 貝原 聡, 細谷 亮, 上原 慶一郎, 今井 幸弘
    (一社)日本消化器外科学会, Oct. 2014, 日本消化器外科学会雑誌, 47(Suppl.2) (Suppl.2), 220 - 220, Japanese

  • Ikuko Kubokawa, Akihiro Yachie, Akira Hayakawa, Satoshi Hirase, Nobuyuki Yamamoto, Takeshi Mori, Tomoko Yanai, Yasuhiro Takeshima, Eiryu Kyo, Goichi Kageyama, Hiroshi Nagai, Keiichiro Uehara, Masaru Kojima, Kazumoto Iijima
    Jun. 2014, BMC PEDIATRICS, 14, English
    [Refereed]
    Scientific journal

  • 頭頸部領域に発生した成人型横紋筋腫の2例
    国分 麻佑, 原 重雄, 南部 順一, 平井 千浦子, 大谷 恭子, 森永 友紀子, 上原 慶一郎, 山崎 隆, 川上 史, Sakai Yasuhiro, 宇佐美 悠, 今井 幸弘, 伊藤 智雄
    Mar. 2014, 日本病理学会会誌, 103(1号) (1号), 309, Japanese
    Research society

  • 婦人科郭清リンパ節内に偶発的に発見された微小なリンパ脈管筋腫症4例の報告
    上原 慶一郎, 川上 史, 神澤 真紀, 高橋 祐一, Hirose Takanori, 松岡 亮介, 山下 大祐, 今井 幸弘, 伊藤 智雄
    Mar. 2014, 日本病理学会会誌, 103(1号) (1号), 385, Japanese
    Symposium

  • 肺門部肺外腫瘍として認められた近位型類上皮肉腫の1例
    大谷 恭子, Sakai Yasuhiro, 上田 佳世, 国分 麻佑, 南部 順一, 平井 千浦子, 森永 友紀子, 上原 慶一郎, 山崎 隆, 川上 史, 原 重雄, 寺村 一裕, Hirose Takanori, 伊藤 智雄
    Mar. 2014, 日本病理学会会誌, 103(1号) (1号), 272, Japanese
    Research society

  • Masaya Saito, Yasushi Seo, Yoshihiko Yano, Keiichiro Uehara, Shigeo Hara, Kenji Momose, Hirotaka Hirano, Hiroshi Yokozaki, Masaru Yoshida, Takeshi Azuma
    Nov. 2013, ANNALS OF HEPATOLOGY, 12(6) (6), 969 - 973, English
    [Refereed]
    Scientific journal

  • 気管支擦過細胞診にてアレルギー性気管支肺アスペルギルス症が疑われた1症例
    川口 智美, 立原 素子, 笠井 大介, 田村 大介, 上原 慶一郎, 大寺 博, 小林 和幸, 船田 泰弘, Sakai Yasuhiro, 西村 善博
    Oct. 2013, 日本臨床細胞学会雑誌, 52(Suppl.2) (Suppl.2), 654, Japanese
    Research society

  • PTTM(pulmonary tumor thrombotic microangiopathy)の2剖検例
    上原 慶一郎, 川上 史, 狛 雄一朗, 森 清, 横崎 宏, 伊藤 智雄
    (一社)日本病理学会, Apr. 2013, 日本病理学会会誌, 102(1) (1), 428 - 428, Japanese
    [Refereed]

  • 右肺末梢に発生した肺動脈内膜肉腫の一例
    西尾 真理, 石原 美佐, 橋本 公夫, 上原 慶一郎, Sakai Yasuhiro, 松岡 亮介, 原 重雄, 横崎 宏
    Apr. 2013, 日本病理学会会誌, 102(1号) (1号), 426, Japanese
    Research society

  • 粘表皮癌を合併した甲状腺低分化癌の1例
    平井 千浦子, Hara Shigeo, 高橋 祐一, 松岡 亮介, 神澤 真紀, 山崎 隆, 上原 慶一郎, Kawakami Fumi, 中井 登紀子, Sakai Yasuhiro, 廣川 満良, 伊藤 智雄
    Apr. 2013, 日本病理学会会誌, 102(1号) (1号), 451, Japanese
    Research society

  • 神経線維腫症1型の若年男性に発症した中脳水道rossette-forming glioneuronal tumorの1例
    高橋 祐一, Sakai Yasuhiro, 松岡 亮介, 平井 千浦子, 国分 麻佑, 友野 絢子, 神澤 真紀, 上原 慶一郎, 森永 友紀子, 大谷 恭子, 山崎 隆, 中井 登紀子, Kawakami Fumi, Hara Shigeo, 大林 千穂, Hirose Takanori, 伊藤 智雄
    Apr. 2013, 日本病理学会会誌, 102(1号) (1号), 395, Japanese
    Research society

  • 初発及び再発時に血管肉腫と神経鞘腫、再々発時に血管肉腫と髄膜腫の混合像を呈した小脳橋角部腫瘍の1例
    Sakai Yasuhiro, 友野 絢子, 高橋 祐一, 松岡 亮介, 平井 千浦子, 国分 麻佑, 神澤 真紀, 上原 慶一郎, 森永 友紀子, 大谷 恭子, 山崎 隆, 中井 登紀子, Kawakami Fumi, Hara Shigeo, 大林 千穂, Hirose Takanori, 伊藤 智雄
    Apr. 2013, 日本病理学会会誌, 102(1号) (1号), 393, Japanese
    Research society

  • 横紋筋様変化を伴った小脳血管芽腫の一例
    友野 絢子, Hara Shigeo, 高橋 祐一, 松岡 亮介, 平井 千浦子, 上原 慶一郎, 神澤 真紀, 山崎 隆, Kawakami Fumi, 中井 登紀子, Sakai Yasuhiro, Hirose Takanori, 伊藤 智雄
    Apr. 2013, 日本病理学会会誌, 102(1号) (1号), 393, Japanese
    Research society

  • Embryonal hyperplasia of Bowman's capsular epitheliumを合併した終末期摘出腎の1例
    松岡 亮介, 高橋 祐一, 平井 千浦子, 友野 絢子, 神澤 真紀, 上原 慶一郎, 山崎 隆, Kawakami Fumi, 中井 登紀子, Hara Shigeo, Sakai Yasuhiro, 大林 千穂, 横崎 宏, 伊藤 智雄
    Apr. 2013, 日本病理学会会誌, 102(1号) (1号), 406, Japanese
    Research society

  • Satoshi Nakamizo, Takashi Sasayama, Takeshi Kondoh, Satoshi Inoue, Ryoji Shiomi, Hirotomo Tanaka, Masamitsu Nishihara, Katu Mizukawa, Keiichiro Uehara, Yu Usami, Eiji Kohmura
    Oct. 2012, JOURNAL OF CLINICAL NEUROSCIENCE, 19(10) (10), 1453 - 1455, English
    [Refereed]
    Scientific journal

  • A case of ovarian carcinosarcoma with neuroendocrine differentiation
    TSUTSUMI Naoyuki, MATSUSHIMA Jun, MEGURO Shiori, UEHARA Keiichiro, SHIMIZU Michio, YASDA Masanori
    Apr. 2012, 診断病理 : Japanese journal of diagnostic pathology, 29(2) (2), 101 - 104, Japanese
    [Refereed]
    Scientific journal

  • A case of pigmented epithelioid melanocytoma
    UEHARA Keiichiro, ICHIMURA Takaya, JIN Ling, ARAI Eiichi, MURATA Shin-ichi, YASUDA Masanori, SASAKI Atsushi, SHIMIZU Michio
    Apr. 2012, 診断病理 : Japanese journal of diagnostic pathology, 29(2) (2), 105 - 107, Japanese
    [Refereed]
    Scientific journal

  • Keiichiro Uehara, Masanori Yasuda, Takaya Ichimura, Hiroshi Yamaguchi, Koji Nagata, Hidekazu Kayano, Atsushi Sasaki, Shin-ichi Murata, Michio Shimizu
    Oct. 2011, DIAGNOSTIC PATHOLOGY, 6, English
    [Refereed]
    Scientific journal

■ MISC
  • 小児松果体部low grade gliomanの1例
    篠山 隆司, 田中 一寛, 上原 慶一郎, 藤田 祐一, 橋口 充, 伊藤 智雄, 廣瀬 隆則, 甲村 英二
    日本脳腫瘍病理学会, May 2019, Brain Tumor Pathology, 36(Suppl.) (Suppl.), 075 - 075, Japanese

  • ENHANCED DIFFERENTIATION AND STRATIFICATION OF BLADDER UROTHELIUM FROM HUMAN INDUCED PLURIPOTENT STEM CELL
    Kotaro Suzuki, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Nobuyuki Hinata, Masato Fujisawa, Takashi Aoi
    Apr. 2019, JOURNAL OF UROLOGY, 201(4) (4), E155 - E156, English
    Summary international conference

  • Comparison between four PD-L1 IHC assays and association with efficacy of Nivolumab in previously treated NSCLC patients regular
    Yuki Sato, Daichi Fujimoto, Keiichiro Uehara, Yuki Imaoka, Kentaro Hayashi, Kaori Ishida, Junya Fukuoka, Yukihiro Imai, Keisuke Tomii
    Oct. 2017, ANNALS OF ONCOLOGY, 28, English
    Summary international conference

  • 術前ホルモン治療によるLuminal乳癌の生物学的特性の変化、特にLuminal HER2乳癌への誘導についての解析
    加藤 大典, 武部 沙也香, 波々伯部 絵理, 橋本 一樹, 一ノ瀬 庸, 木川 雄一郎, 今井 幸弘, 上原 慶一郎, 市川 千宙, 松岡 亮介, 籏智 幸政, 正井 良和
    (一社)日本乳癌学会, Jun. 2016, 日本乳癌学会総会プログラム抄録集, 24回, 296 - 296, Japanese

  • 小腸血管性病変の4例の検討
    市川 千宙, 松岡 亮介, 上原 慶一郎, 今井 幸弘, 細谷 和也, 田川 弘, 橋田 裕毅
    (一社)日本病理学会, Apr. 2016, 日本病理学会会誌, 105(1) (1), 489 - 489, Japanese

  • Adjuvant Trastuzumab投与中の心機能低下のモニターとしてのbrain natriuretic peptide(BNP)測定の有用性
    橋本 一樹, 武部 沙也香, 加藤 大典, 下山 京子, 木川 雄一郎, 古武 剛, 松岡 亮介, 上原 慶一郎, 辻 晃仁, 今井 幸弘
    (一社)日本乳癌学会, Jul. 2015, 日本乳癌学会総会プログラム抄録集, 23回, 574 - 574, Japanese

  • 術前診断が困難であった5型胃癌の2例
    阪本 裕亮, 三木 明, 喜多 亮介, 増井 秀行, 木下 裕光, 岡田 和幸, 山本 健人, 近藤 正人, 八木 真太郎, 瓜生原 健嗣, 小林 裕之, 橋田 裕毅, 貝原 聡, 細谷 亮, 上原 慶一郎
    (一社)日本胃癌学会, Mar. 2015, 日本胃癌学会総会記事, 87回, 408 - 408, Japanese

  • 胸腺多嚢胞性病変15例の検討
    市川 千宙, 松岡 亮介, 山下 大祐, 上原 慶一郎, 今井 幸弘
    (一社)日本病理学会, Mar. 2015, 日本病理学会会誌, 104(1) (1), 339 - 339, Japanese

  • 大腸癌を合併した18例を含む107例の大腸穿孔例の病理学的検討
    松岡 亮介, 市川 千宙, 上原 慶一郎, 山下 大祐, 西尾 真理, 宇佐美 悠, 貝原 聡, 今井 幸弘
    (一社)日本病理学会, Mar. 2015, 日本病理学会会誌, 104(1) (1), 412 - 412, Japanese

  • Minute Lymphangioleiomyomatosis in Pelvic and Paraaortic Lymph Nodes: A Study of 8 Cases
    Keiichiro Uehara, Fumi Kawakami, Yoh Zen, Roman Ltoh, Yakhiro Imal
    Feb. 2015, LABORATORY INVESTIGATION, 95, 312A - 312A, English
    Summary international conference

  • Minute Lymphangioleiomyomatosis in Pelvic and Paraaortic Lymph Nodes: A Study of 8 Cases
    Keiichiro Uehara, Fumi Kawakami, Yoh Zen, Tomoo Itoh, Yukihiro Imai
    Feb. 2015, MODERN PATHOLOGY, 28, 312A - 312A, English
    Summary international conference

  • 高CA19-9血症を呈した脾類表皮嚢胞の1例
    木下 裕光, 八木 眞太郎, 喜多 亮介, 増井 秀行, 阪本 裕亮, 岡田 和幸, 山本 健人, 三木 明, 近藤 正人, 瓜生原 健嗣, 橋田 裕毅, 小林 裕之, 貝原 聡, 細谷 亮, 上原 慶一郎
    (一社)日本内視鏡外科学会, Oct. 2014, 日本内視鏡外科学会雑誌, 19(7) (7), 645 - 645, Japanese

  • FDG-PETにて高集積を呈したSolid pseudopapillary tumorに対して腹腔鏡下尾側膵切除を施行した2例
    八木 真太郎, 近藤 正人, 木下 裕光, 山本 健人, 岡田 和幸, 三木 明, 橋田 裕毅, 小林 裕之, 上原 慶一郎, 今井 幸宏, 貝原 聡, 細谷 亮
    (一社)日本内視鏡外科学会, Oct. 2014, 日本内視鏡外科学会雑誌, 19(7) (7), 482 - 482, Japanese

  • IgG4関連炎症性腹部大動脈瘤の1例
    南部 順一, 山崎 隆, 国分 麻佑, 平井 千浦子, 大谷 恭子, 上原 慶一郎, 森永 友紀子, 川上 史, 原 重雄, 酒井 康裕, 松山 高明, 伊藤 智雄
    (一社)日本病理学会, Mar. 2014, 日本病理学会会誌, 103(1) (1), 349 - 349, Japanese

  • 繰り返す痙攣にて発症した成人cortical ependymomaの1例
    中溝 聡, 田中 宏知, 篠山 隆司, 西原 賢在, 近藤 威, 上原 慶一郎, 伊藤 智雄, 甲村 英二
    日本脳腫瘍病理学会, May 2010, Brain Tumor Pathology, 27(Suppl.) (Suppl.), 125 - 125, Japanese

■ Books And Other Publications
  • 皮膚腫瘍 癌診療指針のための病理診断プラクティス / 転移性腫瘍
    Uehara Keiichiro, 清水道生
    Others, 中山書店, Aug. 2018, Japanese
    Textbook

■ Lectures, oral presentations, etc.
  • Directed differentiation of feeder-free human induced pluripotent stem cells into stratified bladder urothelium
    鈴木 光太郎, AOI MICHIYO, UEHARA KEIICHIRO, HINATA NOBUYUKI, AOI TAKASHI, FUJISAWA MASATO
    The 34th Annual EAU Congress, Mar. 2019, English, バルセロナ, International conference
    Poster presentation

  • Directed differentiation of feeder-free human induced pluripotent stem cells into stratified bladder urothelium
    Kotaro Suzuki, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Nobuyuki Hinata, Masato Fujisawa, Takashi Aoi
    34th Annual EAU Congress, Mar. 2019, English, Barcelona, International conference
    Poster presentation

  • 多発性脳梗塞, 頭蓋内主幹動脈狭窄を認め, 原発性中枢神経血管炎と鑑別を要した血管内リンパ腫の一例
    西居正汰, 渡部俊介, 岡山公宣, Tachibana Hisatsugu, Ueda Takehiro, Sekiguchi Kenji, Uehara Keiichiro, Toda Tatsushi
    日本神経学会第109回近畿地方会, Dec. 2017, Japanese, Japanese Society of Neurology, 大阪, Domestic conference
    Oral presentation

  • 子宮発生腺肉腫の 1例：術前 PETMRI画像と病理標本との対比
    松田 耕平, Ueno Yoshiko, 田中 宇多留, Ebina Yasuhiko, Uehara Keiichiro, 丸尾 原義, 末永 裕子, Yamada Hideto, Itoh Tomoo, Nogami Munenobu, Takahashi Satoru
    The 18th annual symposium of Japanese Society for the Advancement of Women's Imaging, Sep. 2017, Japanese, Japanese Society for the Advancement of Women's Imaging, 兵庫, Domestic conference
    Poster presentation

  • 気管支擦過細胞診にてアレルギー性気管支肺アスペルギルス症が疑われた1症例
    川口 智美, Tachihara Motoko, Kasai Daisuke, Tamura Daisuke, Uehara Keiichiro, Otera Hiroshi, Kobayashi Kazuyuki, Funada Yasuhiro, Sakai Yasuhiro, Nishimura Yoshihiro
    The 52th Annual Meeting of Japan Society of Clinical Cytology, Oct. 2013, Japanese, Japan Society of Clinical Cytology, 大阪, Domestic conference
    Poster presentation

  • 粘表皮癌を合併した甲状腺低分化癌の1例
    平井 千浦子, Hara Shigeo, 高橋 祐一, 松岡 亮介, 神澤 真紀, Yamasaki Takashi, Uehara Keiichiro, Kawakami Fumi, 中井 登紀子, Sakai Yasuhiro, 廣川 満良, Itoh Tomoo
    The 102th Annual Meeting of the Japanese Society of Pathology, Jun. 2013, Japanese, The Japanese Society of Pathology, 札幌, Domestic conference
    Poster presentation

  • 神経線維腫症1型の若年男性に発症した中脳水道rosette-forming glioneuronal tumorの1例
    高橋 祐一, Sakai Yasuhiro, 松岡 亮介, 平井 千浦子, 国分 麻佑, 友野 絢子, 神澤 真紀, Uehara Keiichiro, Morinaga Yukiko, 大谷 恭子, Yamasaki Takashi, 中井 登紀子, Kawakami Fumi, Hara Shigeo, 大林 千穂, Hirose Takanori, Itoh Tomoo
    第102回日本病理学会総会, Jun. 2013, Japanese, 日本病理学会, 札幌, Domestic conference
    Poster presentation

  • 初発及び再発時に血管肉腫と神経鞘腫、再々発時に血管肉腫と髄膜腫の混合像を呈した小脳橋角部腫瘍の1例
    Sakai Yasuhiro, 友野 絢子, 高橋 祐一, 松岡 亮介, 平井 千浦子, 国分 麻佑, 神澤 真紀, Uehara Keiichiro, Morinaga Yukiko, 大谷 恭子, Yamasaki Takashi, 中井 登紀子, Kawakami Fumi, Hara Shigeo, 大林 千穂, Hirose Takanori, Itoh Tomoo
    第102回日本病理学会総会, Jun. 2013, Japanese, 日本病理学会, 札幌, Domestic conference
    Poster presentation

  • 横紋筋様変化を伴った小脳血管芽腫の一例
    友野 絢子, Hara Shigeo, 高橋 祐一, 松岡 亮介, 平井 千浦子, Uehara Keiichiro, 神澤 真紀, Yamasaki Takashi, Kawakami Fumi, 中井 登紀子, Sakai Yasuhiro, Hirose Takanori, Itoh Tomoo
    第102回日本病理学会総会, Jun. 2013, Japanese, 日本病理学会, 札幌, Domestic conference
    Poster presentation

  • PTTM (pulmonary tumor thrombotic microangiopathy) の2剖検例
    Uehara Keiichiro, Kawakami Fumi, Koma Yuichiro, 森 清, Yokozaki Hiroshi, Itoh Tomoo
    第102回日本病理学会総会, Jun. 2013, Japanese, 日本病理学会, 札幌, Domestic conference
    Poster presentation

  • Embryonal hyperplasia of Bowman's capsular epitheliumを合併した終末期摘出腎の1例
    松岡 亮介, 高橋 祐一, 平井 千浦子, 友野 絢子, 神澤 真紀, Uehara Keiichiro, Yamasaki Takashi, Kawakami Fumi, 中井 登紀子, Hara Shigeo, Sakai Yasuhiro, 大林 千穂, Yokozaki Hiroshi, Itoh Tomoo
    第102回日本病理学会総会, Jun. 2013, Japanese, 日本病理学会, 札幌, Domestic conference
    Poster presentation

  • 頚部リンパ節腫大の1例
    Uehara Keiichiro, 友野 絢子, 高橋 祐一, 松岡 亮介, 平井 千浦子, 神澤 真紀, 大谷 恭子, Yamasaki Takashi, Kawakami Fumi, Hara Shigeo, Sakai Yasuhiro, Itoh Tomoo
    第60回日本病理学会近畿支部学術集会, Feb. 2013, Japanese, The Japanese Society of Pathology, 兵庫, Domestic conference
    Oral presentation

  • 脾臓原発悪性リンパ腫の1例
    高橋 祐一, 松岡 亮介, 平井 千浦子, 友野 絢子, 神澤 真紀, Uehara Keiichiro, Yamasaki Takashi, Kawakami Fumi, 中井 登紀子, Hara Shigeo, Sakai Yasuhiro, Itoh Tomoo
    第59回日本病理学会近畿支部学術集会, Dec. 2012, Japanese, The Japanese Society of Pathology, 京都, Domestic conference
    Oral presentation

  • 甲状腺腫瘍の1例
    平井 千浦子, Hara Shigeo, 高橋 祐一, 松岡 亮介, 神澤 真紀, Yamasaki Takashi, Uehara Keiichiro, Kawakami Fumi, 中井 登紀子, Sakai Yasuhiro, 廣川 満良, Itoh Tomoo
    第59回日本病理学会近畿支部学術集会, Dec. 2012, Japanese, The Japanese Society of Pathology, 京都, Domestic conference
    Oral presentation

  • Combination Efficacy of MGMT Promoter Methylation Status and MIB-1 Labeling Index for Pattern of Recurrence in Glioblastoma Treated with Multimodal Treatment
    Uehara Keiichiro, Sasayama Takashi, Miyawaki Daisuke, M Nishihara, Yoshida Kohsuke, H Nishimura, Y Okamoto, Sasaki Ryohei, Sugimura Kazuro
    98th Scientific Assembly and Annual Meeting of The Radiological Society of North America, Nov. 2012, English, The Radiological Society of North America, U.S.A , Chicago, International conference
    Poster presentation

  • 特徴的な上皮細胞増生を伴った終末期摘出腎の1例
    松岡 亮介, 高橋 祐一, 平井 千浦子, 友野 絢子, 神澤 真紀, Uehara Keiichiro, Yamasaki Takashi, Kawakami Fumi, 中井 登紀子, Hara Shigeo, Sakai Yasuhiro, 大林 千穂, Itoh Tomoo
    第58回日本病理学会近畿支部学術集会, Sep. 2012, Japanese, The Japanese Society of Pathology, 兵庫, Domestic conference
    Oral presentation

  • Radiation therapy for brainstem gliomas in children and adults
    Yoshida Kohsuke, NS Sulaiman, H Nishimura, Miyawaki Daisuke, Uehara Keiichiro, Sasayama Takashi, Hayakawa Akira, Sugimura Kazuro, Sasaki Ryohei
    The 14th Asian Oceanian Congress of Radiology, Aug. 2012, English, The 14th Asian Oceanian Congress of Radiology, Australia,Sydney, Purpose: The purpose of this study is to evaluate the outcomes of radiation therapy for brainstem gliomas both in children and adults.Methods: Between 1990 and 2010, 25 patients with brainstem gliomas were treated with radiotherapy. Thirteen were children with a median age of 8 years old (Range: 2 – 18 years old) and 12 were adults with a median age of 56 years old (Range: 29 –, International conference
    Poster presentation

  • Radiation therapy for brainstem gliomas in children and adults
    Yoshida Kohsuke, NS Sulaiman, H Nishimura, Miyawaki Daisuke, Uehara Keiichiro, Sasayama Takashi, Hayakawa Akira, Sasaki Ryohei
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, Purpose: The purpose of this study is to evaluate the outcomes of radiation therapy for brainstem gliomas both in children and adults.Methods: Between 1990 and 2010, 25 patients with brainstem gliomas were treated with radiotherapy. Thirteen were children, International conference
    Poster presentation

  • Impact of MGDG Promoter Methylation Status and MIB-1 Labeling Index on Recurrence Pattern after Multimodal Treatment in Glioblastoma
    Uehara Keiichiro, Sasayama Takashi, Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, Y Okamoto, M Nishihara, Sugimura Kazuro, Sasaki Ryohei
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, International conference
    Poster presentation

  • Radiation Therapy For Brain Stem Gliomas In Children And Adults
    Yoshida Kohsuke, H Nishimura, Miyawaki Daisuke, O Muraoka, Uehara Keiichiro, M Nakayama, Sasaki Ryohei, Sugimura Kazuro
    53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conference
    Oral presentation

  • Dosimetric Analysis of Patterns of Failure for High-grade Glioma with Multimodality Treatment: Relationship to MIB-1 Labeling Index
    Uehara Keiichiro, Sasaki Ryohei, Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, M Nakayama, T Soejima, O Fujii, Sasayama Takashi, Sugimura Kazuro
    53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conference
    Oral presentation

  • Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus: A Retrospective Study
    Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, O Muraoka, M Nakayama, Uehara Keiichiro, Hasegawa Shingo, Nibu Ken-ichi, Sugimura Kazuro, Sasaki Ryohei
    53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conference
    Oral presentation

  • Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus - a Retrospective Study
    Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, O Muraoka, M Nakayama, Uehara Keiichiro, Sugimura Kazuro, Hasegawa Shingo, Nibu Ken-ichi, Sasaki Ryohei
    16ｔｈ ECCO, Sep. 2011, English, ECCO, ストックホルム, ドイツ, International conference
    Oral presentation

  • 頭蓋骨腫瘍の1例
    神澤真紀, 竹内真衣, 夏山順子, 平井千浦子, Uehara Keiichiro, Morinaga Yukiko, Kawakami Fumi, Hara Shigeo, Itoh Tomoo, Hosoda Kokichi
    第49回日本病理学会近畿支部学術集会, May 2010, Japanese, 日本病理学会近畿支部事務局, 大阪, Domestic conference
    Oral presentation

  • Candida glabrataによる感染性心内膜炎の一例
    Uehara Keiichiro, 榎木英介, Itoh Tomoo
    第99回日本病理学会総会, Apr. 2010, Japanese, 日本病理学会, 東京, Domestic conference
    Poster presentation

  • 胸腔鏡下に切除した後縦隔発生Ｃastleman病の１例
    Hashimoto Shotaro, Maniwa Yoshimasa, Nishio Wataru, Funada Yasuhiro, Kotani Yoshikazu, Nishimura Yoshihiro, Takenaka Daisuke, Ohno Yoshiharu, Uehara Keiichiro, Itoh Tomoo
    第91回日本肺癌学会関西支部会, Jan. 2010, Japanese, 日本肺癌学会, 大津, Domestic conference
    Oral presentation

  • 胆管細胞癌との鑑別が困難であった肝瘢痕性病変の1例
    Izaki Kenta, Okada Takuya, Uotani Kensuke, Yamaguchi Masato, Maeda Tetsuo, Yoshikawa Takeshi, Fujii Masahiko, Sugimura Kazuro, Toyama Hirochika, Ku Yonson, Uehara Keiichiro, Itoh Tomoo
    第45回日本肝癌研究会, Jul. 2009, Japanese, 日本肝癌研究会, 福岡, Domestic conference
    Poster presentation

■ Research Themes
  • テラヘルツ波を用いた甲状腺腫瘍に対する革新的診断技術の確立
    手島 直則, 芹田 和則, 上原 慶一郎, 藤田 岳
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2024 - 31 Mar. 2028

  • Mechanisms of muscularis mucosa formation and collapse on gastric organoids derived from human-induced pluripotent stem cell
    Uehara Keiichiro
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Kobe University, 01 Apr. 2020 - 31 Mar. 2022
    Human gastric development has not been well studied. The generation of human pluripotent stem cell-derived gastric organoids (hGOs) comprising gastric marker-expressing epithelium without an apparent smooth muscle structure has been reported. We modified previously reported protocols to generate hGOs with muscularis mucosa (MM) from hiPSCs. Time-course analyses revealed that epithelium development occurred prior to MM formation. Sonic Hedgehog (SHH) and TGF-β1 were secreted by the epithelium. HH and TGF-β signal inhibition prevented MM formation. A mechanical property of the substrate promoted MM formation around hGOs. TGF-β signaling was shown to influence the HH signaling and mechanical properties. In addition, clinical specimen findings suggested the involvement of TGF-β signaling in MM regeneration. HH and TGF-β signaling from the epithelium to the stroma and the mechanical properties of the subepithelial environment may influence the emergence of MM in human stomach tissue.

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