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ISHII Kazunari
Graduate School of Medicine / Department of Medicine
Professor

Researcher basic information

■ Research Keyword
  • normal pressure hydrocephalus
  • Tau PET
  • Amyloid PET
  • Lewy body disease
  • Alzheimer
  • dementia
  • レビー小体型認知症
  • FDG-PET
  • MRI
  • アミロイドイメージング
  • アルツハイマー病
  • 認知症
■ Research Areas
  • Life sciences / Radiology

Research activity information

■ Award
  • Nov. 2016 2016年久田賞(Annals of Nuclear Medicine 論文賞)銅賞

  • Apr. 2008 金原出版株式会社, 平成20年 臨放論文賞

  • Apr. 2006 日本医学放射線学会, 第65回 日本医学放射線学会最多アクセス賞

  • Oct. 1999 日本核医学会, 第37回 日本核医学会賞

  • Feb. 1999 コニカ株式会社, 第5回 コニカ画像科学奨励賞
    石井一成

■ Paper
  • Yasuyuki Kojita, Tomonori Kanda, Shiho Yokoo, Tomoka Kanai, Hiroaki Sanada, Mari Idei, Hiroaki Nagashima, Naoe Jimbo, Takeaki Ishihara, Kazunari Ishii, Takamichi Murakami
    Nov. 2026, Radiology Case Reports
    Scientific journal

  • Kazunari Ishii, Takahiro Yamada, Kohei Hanaoka, Yasuyuki Kojita, Atsushi Kono, Hayato Kaida, Takashi Nihashi, Keita Sakurai, Takashi Kato, Akinori Nakamura
    Aug. 2026, European Journal of Nuclear Medicine and Molecular Imaging
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Kazunari Ishii
    Aug. 2026, Japanese Journal of Radiology
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Ganna Blazhenets, David N. Soleimani-Meigooni, Konstantinos Chiotis, Isabel E. Allen, Gil D. Rabinovici, Renaud La Joie, Liana G. Apostolova, Breton M. Asken, Alexandre Bejanin, Tammie L. S. Benzinger, Tobey J. Betthauser, Marina Bluma, Stephanie Bombois, Pierrick Bourgeat, Vincent Bouteloup, Meredith N. Braskie, Matthias Brendel, Adam M. Brickman, Natalie Bryant, Santiago Bullich, Maria C. Carrillo, Kaitlin Casaletto, David M. Cash, Chiung-Chih Chang, Hsin-I Chang, Yishu Chao, Genevieve Chêne, Gaël Chételat, William Coath, Lyduine E. Collij, Lise Colmant, Maria M. Corrada, Suzanne Craft, Bradford C. Dickerson, Bruno Dubois, Carole Dufouil, Alfonso Fajardo, Gill Farrar, Juan Fortea, Lars Frings, Giovanni B. Frisoni, Raquel C. Gardner, Valentina Garibotto, Johannes S. Gnörich, Brian A. Gordon, Yuna Gu, Yihui Guan, Tengfei Guo, Bernard J. Hanseeuw, Oskar Hansson, Theresa M. Harrison, Qi Huang, Shu-Hua Huang, Leonardo Iaccarino, Kazunari Ishii, Kenji Ishi, William J. Jagust, Sterling C. Johnson, Takashi Kato, Yuta Katsumi, Jeffrey Kaye, Robert A. Koeppe, Guilherme D. Kolinger, Joel H. Kramer, Susan M. Landau, Brigitte Landeau, Patrick J. Lao, Sangwon Lee, Alberto Lleó, Brian J. Lopresti, Val J. Lowe, Jose A. Luchsinger, Maura Malpetti, Xiaoxie Mao, Andrew March, Colin L. Masters, Philipp T. Meyer, Florence Mezenge, Elizabeth C. Mormino, Maria Franquesa-Mullerat, Akinori Nakamura, Agneta Nordberg, John T. O’Brien, Sid E. O’Bryant, Ioannis Pappas, Debora E. Peretti, Lisa Quenon, Christopher C. Rowe, James B. Rowe, Marc D. Rudolph, Gemma Salvadó, Jonathan M. Schott, Daniel L. Schwartz, Christopher G. Schwarz, Sang Won Seo, Mahnaz Shekari, Lisa C. Silbert, Ruben Smith, Heather M. Snyder, Andrzej Sokolowski, Reisa A. Sperling, Pan Sun, Jacinda Z. Taggett, Arthur W. Toga, Alexandra Touroutoglou, David E. Vaillancourt, Elsmarieke van de Giessen, Jort Vijverberg, Prashanthi Vemuri, Nicolas Villain, Victor L. Villemagne, Sylvia Villeneuve, Wei-en Wang, Michael Weiner, Davis Woodworth, Cally Xiao, Fang Xie, Yeojun Yoon, Christina B. Young, Mijin Yun
    Importance Amyloid positron emission tomography (PET) is increasingly used in research and clinical settings to determine the etiology of cognitive decline and eligibility for amyloid-targeting therapies. To assist with amyloid PET evaluation and to guide clinical decision-making, images can be quantified in a standardized unit called Centiloid, the interpretation of which can vary according to the method and threshold used. Objective To collect Centiloid values from available studies and determine robust positivity cutoffs using data-driven methods and correspondence with visual reads. Data Sources PubMed search (October 2024) identified studies with Centiloid values. Corresponding authors were invited to share individual participant data. Additional data were obtained through access-controlled repositories and conference outreach (July 2024-July 2025). Study Selection Studies were included if they provided Centiloids, radiotracer, age, and sex. Data Extraction and Synthesis Each study was analyzed using a unified statistical pipeline; study estimates were pooled using random-effects meta-analysis. Main Outcomes and Measures Gaussian mixture models (GMMs) were fitted to Centiloid values for each study. In studies with a bimodal distribution (per integrated completed likelihood), single cutoffs for positivity were set as mean plus 2 SDs of the lower gaussian component. Using GMMs, a double-cutoff approach defined a lower certainty range using a 90% posterior probability cutoff for assignment to the low (amyloid-negative) vs high (amyloid-positive) component. An alternative Centiloid cutoff was derived from maximizing the correspondence (Cohen κ) with the binary visual reads when available. Results This meta-analysis included cross-sectional amyloid PET scans acquired with 5 radiotracers from 49 227 participants across 53 studies from 15 countries (mean age, 71 years; 54% female, 62% cognitively impaired). The data-driven GMM approach identified a bimodal distribution in 51 studies (n = 48 786), resulting in a single cutoff for positivity of 18 Centiloids (95% CI,16-19; I 2  = 97%). The double-cutoff approach revealed high confidence for interpreting scans as negative when Centiloid values were lower than 11 (95% CI, 9-13; I 2  = 95%) and interpreting scans as positive if Centiloid values were higher than 26 (95% CI, 24-28; I 2  = 95%). In analyses of correspondence with binary (positive or negative) visual reads of amyloid PET scans (n = 35 045; 36 studies), Centiloids were highly predictive of visual positivity (Cohen κ, 0.86; 95% CI, 0.83-0.89; I 2  = 96%) with a cutoff of 27 Centiloids (95% CI, 24-30; I 2  = 80%). Conclusions and Relevance In this individual participant data meta-analysis, positivity cutoffs converged around 18 Centiloids (data-driven) and 27 Centiloids (visual reads). Findings from a double-cutoff analysis suggest that scans in the 11 to 26 Centiloid range should be interpreted with caution depending on the context of use.
    American Medical Association (AMA), Jul. 2026, JAMA
    Scientific journal

  • Nonoka Yamagata, Tomoko Hyodo, Masatomo Kimura, Takaaki Murase, Fumiaki Ono, Koji Sugimoto, Takuya Nakai, Takao Satou, Kazunari Ishii
    We report a case of mucinous cystic neoplasm that presented with intratumoral bleeding. The tumor showed unusual imaging morphology mimicking echinococcosis and other cystic liver lesions. A woman in her 60s with frequent contact with multiple dogs presented with an incidentally detected liver mass. Computed tomography and magnetic resonance imaging revealed a 53-mm lobulated hepatic mass with a central hematoma and peripheral cysts. Differential diagnoses included hemorrhagic cyst, echinococcosis, hepatocellular adenoma, mucinous cystic neoplasm, and metastatic tumors. Serologic testing for echinococcus antibodies was performed based on the imaging findings and yielded negative results. The patient underwent surgical resection, and the lesion was diagnosed as mucinous cystic neoplasm. No signs of recurrence were observed during the 5-year follow-up period.
    Jun. 2026, Radiology case reports, 21(6) (6), 2664 - 2668, English, International magazine
    Scientific journal

  • Yuji Nozaki, Atsuhiro Yamamoto, Daisuke Tomita, Tomoko Hyodo, Hayato Kaida, Kazunari Ishii, Koji Kinoshita
    Abstract Objectives To compare diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) with ^18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for assessing disease activity in large-vessel vasculitis (LVV), and to evaluate whether segment-level analysis provides complementary information beyond global grading. Methods We enrolled 25 patients with LVV (Takayasu arteritis [TAK], n = 11; giant cell arteritis [GCA], n = 14). Two blinded readers graded 11 arterial territories (18 segments) on a four-point visual scale for DWIBS and FDG-PET/CT. Global imaging grades were calculated as segment-averaged means. Correlations with serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were assessed. Results Global mean DWIBS grades correlated significantly with FDG-PET/CT grades (r = 0.72) and with CRP levels (r = 0.53). Territory-level mapping revealed diffuse central aortic involvement in GCA, whereas TAK showed more focal and segment-limited patterns. DWIBS demonstrated lower sensitivity in motion-prone regions but appeared to better reflect clinical activity and more frequently detected subclavian artery involvement in TAK compared with FDG-PET/CT. Residual vascular signals were also observed in some patients classified as being in clinical remission. Conclusions DWIBS shows good agreement with FDG-PET/CT and provides a radiation- and contrast-free approach for assessing LVV. Global mean grades alone showed limited discriminatory power and may underestimate disease activity in focal or segment-limited involvement. Integrating segment-level imaging findings with clinical and laboratory markers may improve assessment of disease activity. Multicenter validation and longitudinal studies are warranted.
    Oxford University Press (OUP), May 2026, Modern Rheumatology
    Scientific journal

  • Yuji Nozaki, Atsuhiro Yamamoto, Daisuke Tomita, Tomoko Hyodo, Hayato Kaida, Kazunari Ishii, Koji Kinoshita
    OBJECTIVES: To compare diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) with ^18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for assessing disease activity in large-vessel vasculitis (LVV), and to evaluate whether segment-level analysis provides complementary information beyond global grading. METHODS: We enrolled 25 patients with LVV (Takayasu arteritis [TAK], n = 11; giant cell arteritis [GCA], n = 14). Two blinded readers graded 11 arterial territories (18 segments) on a four-point visual scale for DWIBS and FDG-PET/CT. Global imaging grades were calculated as segment-averaged means. Correlations with serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were assessed. RESULTS: Global mean DWIBS grades correlated significantly with FDG-PET/CT grades (r = 0.72) and with CRP levels (r = 0.53). Territory-level mapping revealed diffuse central aortic involvement in GCA, whereas TAK showed more focal and segment-limited patterns. DWIBS demonstrated lower sensitivity in motion-prone regions but appeared to better reflect clinical activity and more frequently detected subclavian artery involvement in TAK compared with FDG-PET/CT. Residual vascular signals were also observed in some patients classified as being in clinical remission. CONCLUSIONS: DWIBS shows good agreement with FDG-PET/CT and provides a radiation- and contrast-free approach for assessing LVV. Global mean grades alone showed limited discriminatory power and may underestimate disease activity in focal or segment-limited involvement. Integrating segment-level imaging findings with clinical and laboratory markers may improve assessment of disease activity. Multicenter validation and longitudinal studies are warranted.
    May 2026, Modern rheumatology, English, International magazine
    Scientific journal

  • Kazunari Ishii, Takahiro Yamada, Kohei Hanaoka, Hayato Kaida, Yasuyuki Kojita, Atsushi Kono, Kenji Ishii, Takashi Kato, Akinori Nakamura
    OBJECTIVE: To verify the regional distribution, especially off-target binding, of the tracer 18F-MK-6240, on tau PET images obtained with a high-resolution dedicated brain PET scanner. METHODS: We retrospectively analyzed the 18F-MK-6240 PET data from subjects with cognitive decline who were enrolled in the BATON study. All scans were acquired using the same high-resolution brain-dedicated PET system. We calculated the standardized uptake value ratios (SUVRs) by using manually defined restricted cerebellar volumes of interest (VOIs) excluding meningeal spill-in, and we compared these SUVRs with those obtained using the conventional CenTauR cerebellar gray matter reference. We also quantified the off-target uptake in regions including the meninges, retina, and ethmoid sinus. Group comparisons and interaction effects were analyzed by t-tests and an ANOVA, and ROC analyses were performed to assess the diagnostic accuracy of each method. RESULTS: Off-target accumulations were clearly observed in the substantia nigra, globus pallidum, and pineal gland. Higher extra-cerebral cortical uptake was observed in the meninges and centrum semiovale in tau-positive individuals, although these differences did not remain significant after a multiple comparison correction. The SUVRs derived with the use of restricted cerebellar VOIs were significantly higher than those from the CenTauR cerebellar VOIs in both the tau-positive and tau-negative groups (p < 0.01). A significant interaction between the diagnostic group and the reference VOI choice was detected (p = 0.019). The ROC analysis showed excellent diagnostic performance, with AUCs of 0.930 for CenTauR and 0.984 for the restricted reference VOIs (a nonsignificant difference). CONCLUSION: 18F-MK-6240 PET imaging using a high-resolution brain-dedicated PET scanner revealed notable off-target binding and meningeal spill-in, which significantly affect quantification depending on the reference VOI selection. Optimizing reference regions by excluding extracerebral contamination enhances the reliability of tau PET analyses and may be crucial for longitudinal studies and multicenter trials.
    May 2026, Annals of Nuclear Medicine, 40(5) (5), 597 - 604, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Shigeki Katakami, Hideki Kanemoto, Daiki Taomoto, Yuto Satake, Takashi Suehiro, Shunsuke Sato, Kenji Yoshiyama, Tetsuo Kashibayashi, Ryuichi Takahashi, Kenji Tagai, Shunichiro Shinagawa, Kazunari Ishii, Hiroaki Kazui, Manabu Ikeda
    BACKGROUND AND PURPOSE: Neuropsychiatric symptoms (NPS) are frequent in dementia and mild cognitive impairment (MCI), yet their reported associations with white matter hyperintensities (WMHs) remain inconsistent. We examined item-level associations between WMHs and NPS across Alzheimer's disease dementia (ADD), dementia with Lewy bodies (DLB), and amnestic MCI (aMCI). METHODS: This multicenter retrospective study involved 523 patients: 276 with ADD, 67 with DLB, and 180 with aMCI. Three-dimensional T1-weighted and T2-fluid-attenuated inversion recovery magnetic resonance images were processed with BAAD (Brain Anatomical Analysis using Diffeomorphic Deformation) software to quantify WMH volume (WMHV) and gray matter volume (GMV), normalized to total intracranial volume (TIV). NPS were assessed using the Neuropsychiatric Inventory. Multiple regression analyses were performed within each group, adjusting for GMV/TIV, age, sex, years of education, Clinical Dementia Rating-Sum of Boxes score, and institution. RESULTS: In the aMCI group, higher WMHV/TIV was positively associated with depression, apathy, and disinhibition, and negatively with delusions. Subregional analyses revealed NPS-specific topographic patterns. No significant associations were detected in the ADD or DLB group. GMV/TIV was positively associated with delusions in the ADD group, but negatively associated with hallucinations in the DLB group. CONCLUSIONS: Associations between WMHs and NPS were evident in the aMCI group but absent in the ADD and DLB groups, suggesting a stage-dependent effect. WMHs may contribute to NPS primarily in prodromal stages, whereas their influence may be overshadowed by neurodegenerative pathology in dementia. Clarifying the mechanisms underlying WMHs is critical for evaluating their potential as intervention targets.
    Mar. 2026, Journal of clinical neurology (Seoul, Korea), 22(2) (2), 183 - 192, English, International magazine
    Scientific journal

  • Koichi Miyazaki, Hiroya Morita, Kazunari Ishii
    Idiopathic normal pressure hydrocephalus (iNPH) is a condition in the elderly commonly treated with ventriculoperitoneal (VP) or lumboperitoneal (LP) shunt surgery. iNPH frequently coexists with Alzheimer's disease (AD), for which anti-amyloid-β antibodies such as lecanemab have recently become available. Because lecanemab may cause hemorrhagic imaging abnormalities, the timing of shunt surgery in relation to antibody therapy raises concern regarding perioperative bleeding risk. Here, we report two patients with iNPH and AD treated with different sequences of shunt surgery and lecanemab. No hemorrhagic complications were observed, although conclusions regarding safety should be interpreted cautiously.
    Feb. 2026, Acta neurochirurgica, 168(1) (1), English, International magazine
    Scientific journal

  • Takashi NAKATA, Kenichi SHIMADA, Akira TERASHIMA, Haruhiko ODA, Yuko SUENAGA, Yutaka KOIDE, Ryota KAWASAKI, Takahiro YAMADA, Kazunari ISHII
    Abstract

    Objective Alzheimer’s disease (AD) involves amyloid-β (Aβ) and phosphorylated tau (p-tau) pathology. Cerebrospinal fluid (CSF) biomarkers reflect these changes but require invasive lumbar puncture, whereas amyloid positron emission tomography (PET) is less invasive but expensive and typically limited to a single reimbursed scan. 2-Deoxy-2-[ 18 F]-fluoro-D-glucose (FDG)-PET is less invasive than lumbar puncture; however, it is not covered by health insurance in Japan. In contrast, brain perfusion single photon emission computed tomography (SPECT) is widely available, repeatable, and cost-effective compared to FDG-PET. We investigated the correlation between regional relative cerebral blood flow (rCBF) measured by SPECT and CSF biomarkers, and evaluated whether rCBF reductions could predict CSF biomarker levels.Methods In this retrospective study, 88 patients underwent Mini-Mental State Examination (MMSE), MRI, N -isopropyl- p -[ 123 I] iodoamphetamine (IMP)-SPECT, and CSF biomarker assessments. SPECT data were normalized to cerebellar counts and co-registered to MRI. Voxel-wise analyses identified the regions where decreased rCBF correlated with CSF biomarkers. Simple regression evaluated correlations between the standard uptake value ratios (SUVRs) of posterior cingulate (PC), bilateral parietal cortices, MMSE, age, sex and biomarker levels. Multiple regression models incorporated the three SUVRs, MMSE, and age. Predicting validity was assessed using correlation coefficient (r), coefficient of determination (r²), and Bland–Altman analysis.Results Voxel-wise analysis revealed positive correlations between CSF Aβ42 level and CBF in PC and angular gyrus, while CSF t-tau and p-tau correlated negatively with parietal hypoperfusion. CSF Aβ40 showed no significant correlations. Simple regression demonstrated weak correlations, such as CSF Aβ42 with right parietal cortex (r = 0.47). Multiple regression yielded moderate predictability for CSF Aβ42 (r² = 0.42), whereas other biomarkers were poorly predicted.Conclusion SPECT revealed AD-typical hypoperfusion patterns and demonstrated modest potential to estimate CSF Aβ42 levels, but not CSF Aβ40, t-tau, or p-tau. Although SPECT cannot substitute CSF biomarker measurements or amyloid/tau PET, SPECT may serve as a pre-screening tool to identify patients requiring definitive biomarker testing.

    Springer Science and Business Media LLC, Feb. 2026

  • Misa Honda, Takahiro Yamada, Shogo Watanabe, Aya Watanabe, Takashi Nagaoka, Mitsutaka Nemoto, Katsuhiro Mikami, Kohei Hanaoka, Hayato Kaida, Hisashi Handa, Kazunari Ishii, Yuichi Kimura
    Society of Nuclear Medicine, Jan. 2026, Journal of Nuclear Medicine Technology, jnmt.125.270154 - jnmt.125.270154
    Scientific journal

  • Tomoyo Fukami, Akira Hamada, Kenichi Suda, Hayato Kaida, Yukihiro Yoshida, Kazuhiro Kitajima, Kimiteru Ito, Tetsuro Sekine, Kyoshiro Takegahara, Hiromitsu Daisaki, Masaki Hashimoto, Takanobu Kabasawa, Takashi Yamasaki, Seiichi Hirota, Jitsuo Usuda, Kazunari Ishii, Junichi Soh, Tetsuya Mitsudomi, Yasuhiro Tsutani
    OBJECTIVES: Reliable prognostic tools are essential for improving the management of stage I non-small cell lung cancer. Whereas fluorodeoxyglucose positron emission tomography has proven valuable, metrics such as maximum standardized uptake value are limited by interinstitutional variability. This study evaluates the Deauville score for its clinical utility in predicting pathological invasiveness and survival outcomes. METHODS: Data were retrospectively collected from 495 patients with stage I non-small cell lung cancer who underwent pulmonary resection across 4 institutions in Japan. Tumors were classified by a visual 5-point scale Deauville scores into groups: 1 and 2, 3, and 4 and 5. Associations between these scores, pathological invasiveness (defined as lymphatic invasion, vascular invasion, pleural invasion, and/or nodal involvement), and survival outcomes were analyzed. RESULTS: High Deauville scores (4 and 5) were significantly associated with pure solid tumors (85%; P < .0001) and pathological invasiveness (66%; P < .0001). Multivariable analysis showed the Deauville score to be an independent predictor of invasiveness (odds ratio, 10.145; P < .0001 for scores 4 and 5 vs 1 and 2). Survival analyses revealed poorer outcomes for patients with scores of 4 and 5, with a 5-year recurrence-free survival of approximately 60% (P < .0001). Even in part-solid tumors, scores of 4 and 5 were linked to significantly worse recurrence-free survival compared with scores of 1 and 2 or 3 (P < .0001). CONCLUSIONS: The Deauville score provides a straightforward and consistent method to predict pathological invasiveness and survival in stage I non-small cell lung cancer. Its reliability and reproducibility across institutions highlight its potential as a valuable tool for both clinical practice and large-scale research.
    Dec. 2025, The Journal of thoracic and cardiovascular surgery, 170(6) (6), 1784 - 1794, English, International magazine
    Scientific journal

  • Fubuki Sawa, Daisuke Fujita, Kenichi Shimada, Hideo Aihara, Toshiyuki Uehara, Yutaka Koide, Ryota Kawasaki, Kazunari Ishii, Syoji Kobashi
    PURPOSE: Distinguishing idiopathic normal pressure hydrocephalus (iNPH) from progressive supranuclear palsy (PSP) presents a clinical challenge due to overlapping clinical symptoms such as gait disturbances and cognitive decline. This study presents a novel multi-scale deep learning framework that integrates global and local magnetic resonance imaging (MRI) features using a mixture of experts (MoE) mechanism, enhancing diagnostic accuracy and minimizing interobserver variability. METHODS: The proposed framework combines a 3D convolutional neural network (CNN) for capturing global volumetric features with a 2.5D recurrent CNN focusing on disease-specific regions of interest (ROIs), including the lateral ventricles, high convexity sulci, midbrain, and Sylvian fissures. The MoE mechanism dynamically weights global and local features, optimizing the classification process. Model performance was assessed using stratified fivefold cross-validation on T1-weighted MRI from 118 patients (53 iNPH, 65 PSP) to ensure balanced class distributions across training folds. RESULTS: The MoE model using ResNet-34 achieved an accuracy of 0.983 (95% CI 0.875-1.000), a recall of 0.985 (95% CI 0.750-1.000), a precision of 0.986 (95% CI 0.769-1.000), and an area under the curve (AUC) of 1.000 (95% CI 1.000-1.000), outperforming traditional morphological markers and single-branch deep learning models. The MoE mechanism allowed adaptive weighting of global and local features, contributing to both improved robustness and interpretability. Grad-CAM visualizations highlighted disease-specific regions, demonstrating that the model focused on relevant features in both successful and failure modes of the 3D CNN expert for iNPH and PSP. CONCLUSION: The dynamic integration of global and local MRI features through the MoE framework offers a powerful, robust, and interpretable tool for differentiating iNPH from PSP. This approach reduces reliance on subjective visual assessments and has the potential for broader clinical application through dataset expansion and multicenter validation.
    Dec. 2025, International journal of computer assisted radiology and surgery, 20(12) (12), 2413 - 2422, English, International magazine
    Scientific journal

  • Naohiro Kimura, Yoshihiro Chadani, Ryo Kawai, Ryoko Fujito, Hideki Kanemoto, Ryuichi Takahashi, Tetsuo Kashibayashi, Shunichiro Shinagawa, Kenji Tagai, Kazunari Ishii, Manabu Ikeda, Hiroaki Kazui
    OBJECTIVE: The association between core clinical features and anxiety and the neural basis of anxiety in patients with dementia with Lewy bodies (DLB) are unknown. Therefore, this study examined the core clinical features associated with anxiety in DLB and identified the brain regions associated with anxiety using statistical imaging analysis. METHODS: This study was conducted using a part of the data from "The Japan multicenter study: Behavioral and psychological symptoms Integrated Research in Dementia-Retrospective Neuroimaging part". Overall, 40 patients with probable DLB whose clinical dementia rating score was either 0.5 or 1 were included in this study. Anxiety was evaluated using the Neuropsychiatric Inventory (NPI). The incidence of each of the 4 core features was compared between patients with and without anxiety, and the brain regions associated with anxiety were examined using single-photon emission computed tomography data. RESULTS: Patients with DLB with anxiety had a significantly higher percentage of fluctuating cognition than those without anxiety. The NPI anxiety score was significantly negatively correlated with regional cerebral blood flow in the right supramarginal gyrus in patients with DLB. CONCLUSION: Anxiety in DLB is associated with fluctuating cognition. It is also likely that the brain regions associated with anxiety in DLB are potentially influenced by the neurofunctional characteristics of DLB, in which the parietal lobes are more likely to be impaired.
    Sep. 2025, International Journal of Geriatric Psychiatry, 40(9) (9), e70150, English, International magazine
    Scientific journal

  • MRI画像を用いた全脳および疾患特異的MRI特徴のMoE統合によるiNPH・PSP自動鑑別
    澤 風吹, 嶋田 兼一, 石井 一成, 小橋 昌司
    (一社)日本医用画像工学会, Aug. 2025, 日本医用画像工学会大会予稿集, 44回, 66 - 66, Japanese

  • マルチモダリティ脳画像を用いたマルチタスク深層学習による非侵襲的脳脊髄液バイオマーカ値推定手法
    長谷川 莉玖, 仲田 崇, 石井 一成, 小橋 昌司
    (一社)日本医用画像工学会, Aug. 2025, 日本医用画像工学会大会予稿集, 44回, 68 - 68, Japanese

  • MRI画像を用いた全脳および疾患特異的MRI特徴のMoE統合によるiNPH・PSP自動鑑別
    澤 風吹, 嶋田 兼一, 石井 一成, 小橋 昌司
    (一社)日本医用画像工学会, Aug. 2025, 日本医用画像工学会大会予稿集, 44回, 252 - 253, Japanese

  • Ilya Ardakani, Takahiro Yamada, Sayaka Iwano, Sunil Kumar Maurya, Kazunari Ishii
    BACKGROUND: Widely used in oncology PET, 2-deoxy-2- 18 F-FDG PET is more accessible and affordable than amyloid PET, which is a crucial tool to determine amyloid positivity in diagnosis of Alzheimer disease (AD). This study aimed to leverage deep learning with residual 3D convolutional neural networks (3DCNN) to develop a robust model that predicts amyloid-β positivity by using FDG-PET. PATIENTS AND METHODS: In this study, a cohort of 187 patients was used for model development. It consisted of patients ranging from cognitively normal to those with dementia and other cognitive impairments who underwent T1-weighted MRI, 18 F-FDG, and 11 C-Pittsburgh compound B (PiB) PET scans. A residual 3DCNN model was configured using nonexhaustive grid search and trained on repeated random splits of our development data set. We evaluated the performance of our model, and particularly its robustness, using a multisite data set of 99 patients of different ethnicities with images at different site harmonization levels. RESULTS: Our model achieved mean AUC scores of 0.815 and 0.840 on images without and with site harmonization correspondingly. Respectively, it achieved higher AUC scores of 0.801 and 0.834 in the cognitively normal (CN) group compared with 0.777 and 0.745 in the dementia group. As for F1 score, the corresponding mean scores were 0.770 and 0.810 on images without and with site harmonization. In the CN group, it achieved lower F1 scores of 0.580 and 0.658 compared with 0.907 and 0.931 in the dementia group. CONCLUSIONS: We demonstrated that residual 3DCNN can learn complex 3D spatial patterns in FDG-PET images and robustly predict amyloid-β positivity with significantly less reliance on site harmonization preprocessing.
    Aug. 2025, Clinical Nuclear Medicine, 50(8) (8), 707 - 713, English, International magazine
    Scientific journal

  • Yoshiyuki Asai, Mika Yamamuro, Takahiro Yamada, Yuichi Kimura, Kazunari Ishii, Yusuke Nakamura, Yujiro Otsuka, Yohan Kondo
    Objective. Temporal changes in volumetric breast density (VBD) may serve as prognostic biomarkers for predicting the risk of future breast cancer development. However, accurately measuring VBD from archived x-ray mammograms remains challenging. In a previous study, we proposed a method to estimate volumetric breast density using imaging parameters (tube voltage, tube current, and exposure time) and patient age. This approach, based on a multiple regression model, achieved a determination coefficient (R2) of 0.868.Approach. In this study, we developed and applied machine learning models-Random Forest, XG-Boost-and the deep learning model Residual Network (ResNet) to the same dataset. Model performance was assessed using several metrics: determination coefficient, correlation coefficient, root mean square error, mean absolute error, root mean square percentage error, and mean absolute percentage error. A five-fold cross-validation was conducted to ensure robust validation.Main results. The best-performing fold resulted in R2values of 0.895, 0.907, and 0.918 for Random Forest, XG-Boost, and ResNet, respectively, all surpassing the previous study's results. ResNet consistently achieved the lowest error values across all metrics.Significance. These findings suggest that ResNet successfully achieved the task of accurately determining VBD from past mammography-a task that has not been realised to date. We are confident that this achievement contributes to advancing research aimed at predicting future risks of breast cancer development by enabling high-accuracy time-series analyses of retrospective VBD.
    Jul. 2025, Biomedical physics & engineering express, 11(4) (4), English, International magazine
    Scientific journal

  • Junki Fukuda, Hiroshi Doi, Atsushi Kono, Takaya Inagaki, Naoko Ishida Hamazawa, Saori Tatsuno Imamura, Takuya Uehara, Masahiro Inada, Kiyoshi Nakamatsu, Makoto Hosono, Kazunari Ishii, Yukinori Matsuo
    PURPOSE: This study aimed to assess the potential of prognostic factors including consolidation tumor ratio (CTR) on treatment outcomes in patients with clinical stage 0-IA non-small cell lung cancer (NSCLC) undergoing stereotactic body radiotherapy (SBRT). METHODS: The analysis included data of 63 patients with 67 lesions of clinical stage 0-IA NSCLC treated with SBRT. According to the Union for International Cancer Control 8th edition, the following tumor stages were observed: Tis, 3; T1mi, 2; T1a, 11; T1b, 29; and T1c, 22. The prescribed dose was 48 (range, 42-52) Gy in four fractions. RESULTS: The median follow-up was 29.3 (range: 2.4-120.5) months. The five-year local control (LC), overall survival, and progression-free survival (PFS) rates were 89.4%, 60.3%, and 40.5%, respectively. Squamous cell carcinoma (Sq) and Dmax < 125 GyBED10 for planning target volume (PTV) were associated with a worse LC (p = 0.001 and 0.017, respectively). Patients with Sq, T1b-c, CTR > 0.25, PTV ≥ 30 cm3 tumors were associated with worse PFS than those with non-Sq, ≤ cT1a, CTR ≤ 0.25, PTV < 30 cm3 tumors (p = 0.049, 0.004, 0.038, and 0.004, respectively). No recurrences, metastases, or deaths were found in patients with CTR ≤ 0.25 (n = 5). CONCLUSION: In patients with stage 0-IA lung cancer treated with SBRT, tumors classified as ≤ T1a showed a better PFS than T1b-c. NSCLC with a low CTR of ≤ 0.25 seemed to have a low risk of recurrence after SBRT.
    Jun. 2025, Thoracic cancer, 16(11) (11), e70110, English, International magazine
    Scientific journal

  • Kengo Ito, Yukihiko Washimi, Takashi Kato, Keisuke Suzuki, Yasuomi Ouchi, Chigusa Watanabe, Yoshihide Sunada, Yumiko Kutoku, Kazunari Ishii, Kenji Ishii, Michio Kitayama, Etsuro Matsubara, Noriyuki Kimura, Harumasa Takano, Hiroaki Adachi, Kazuhiro Hara, Takeshi Kawarabayashi, Mikio Shoji, Norio Sugimoto
    Background18F-fluoro-2-deoxy-2-D-glucose positron emission tomography (18F-FDG PET) is a biomarker of neuronal injury, according to the revised National Institute on Aging-Alzheimer's Association criteria.ObjectiveThis multicenter prospective cohort study aimed to evaluate the value of 18F-FDG PET for differential diagnosis of Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) in comparison with phosphorylated tau protein (p-tau181) in cerebrospinal fluid (CSF).MethodsIn total, 138 patients (AD, 119; FTLD, 19) from 11 participating institutions underwent clinical and neuropsychological examinations, magnetic resonance imaging (MRI), CSF examination, and 18F-FDG PET at baseline. The cases were visually classified into predefined dementia patterns using 18F-FDG PET by three experts. A region-of-interest (ROI)-based automated analysis of 18F-FDG PET was also performed. The participants were followed up for 12 months, and the clinical diagnosis of dementia was re-evaluated.ResultsThe sensitivity, specificity, and accuracy of the visual reading of18 F-FDG PET for differentiating AD from FTLD were 94%, 78%, and 92%, respectively. In contrast, those of p-tau181 in CSF were 62%, 79%, and 65%, respectively. The sensitivity, the primary endpoint, was 32% higher for 18F-FDG PET than for p-tau181 in CSF. Additionally, the accuracy, the secondary endpoint, was 27% higher for 18F-FDG PET than for p-tau181 in CSF. In addition to the visual reading of 18F-FDG PET, the ROI-based automated analysis showed sensitivity, specificity, and accuracy of 81%, 79%, and 81%, respectively.ConclusionsThis study showed that the diagnostic performance of 18F-FDG PET in differential diagnosis of AD and FTLD was higher than that of p-tau181 in CSF.Trial registrationUMIN-CTR (UMIN 000016427, https://www.umin.ac.jp/ctr/) and Japan Registry of Clinical Trials (jRCTs041180098, https://jrct.mhlw.go.jp/).
    May 2025, Journal of Alzheimer's disease : JAD, 106(1) (1), 13872877251338691 - 13872877251338691, English, International magazine
    Scientific journal

  • Takahiro Yamada, Yuichi Kimura, Shogo Watanabe, Aya Watanabe, Misa Honda, Takashi Nagaoka, Mitsutaka Nemoto, Kohei Hanaoka, Hayato Kaida, Yasuyuki Kojita, Minoru Yamada, SungWoon Im, Atsushi Kono, Kazunari Ishii
    BACKGROUND: Since the approval of disease-modifying drugs for Alzheimer's disease, the demand for amyloid positron emission tomography (PET) scans, which are crucial for determining treatment eligibility, is expected to increase significantly. We thus investigated the ability of an algorithm to predict amyloid accumulation from 18F-fluorodeoxyglucose (FDG)-PET images for use in amyloid PET screening. METHODS: We analyzed the images of 194 subjects with cognitive disorders who had undergone brain FDG-PET, amyloid PET using Pittsburgh compound-B (11C-PiB), and MRI scans at Kindai University Hospital between 2011 and 2018. Among them, 108 subjects showed positive amyloid accumulation; the other 86 did not. For the 108 positive cases, the input values were the region of interest-based calculated from the automatic anatomical labeling template, which divides the brain into 120 regions, and applied to the anatomically standardized FDG-PET images of each subject. We then used a support vector machine (SVM) machine learning algorithm and conducted a tenfold cross-validation to assess the algorithm's accuracy for predicting amyloid accumulation from FDG-PET images. RESULTS: We observed 81.5% accuracy, 78.5% sensitivity, 84.6% specificity, and an area under the curve (AUC) of 0.846 during training. The validation results for the trained model revealed 85.9% accuracy, 88.4% sensitivity, 81.0% specificity, and an AUC of 0.918. CONCLUSION: These results indicate that the performance of our algorithm to predict amyloid accumulation from 18FDG-PET images is adequate for use in amyloid PET scan screenings.
    May 2025, Japanese journal of radiology, 43(9) (9), 1541 - 1549, English, Domestic magazine
    Scientific journal

  • 櫻井 圭太, 金田 大太, 小路田 泰之, 石井 一成, 池辺 洋平, 工藤 與亮
    学研メディカル秀潤社, Apr. 2025, 画像診断, 45(6) (6), 598 - 601

  • Akihiro Takasaki, Yoshiyuki Nishio, Yuto Satake, Matasaburo Kobayashi, Mariko Sakai, Kohji Mori, Kazunari Ishii, Manabu Ikeda
    Here we present the cases of two individuals with language and behavioral symptoms indicative of the early clinical manifestations of both Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD). Phonological language symptoms similar to those evident in logopenic variant primary progressive aphasia suggested AD pathology, while semantic impairment and behavioral changes (ie, abnormal eating behavior and disinhibition) suggested a diagnosis of FTLD. Multimodal neuroimaging studies revealed underlying neuropathology indicative of primary tauopathy with presumable 3/4-repeat isoform, devoid of amyloid deposition. We suggest that these cases may represent a previously unrecognized syndrome associated with non-Alzheimer primary tauopathy.
    Apr. 2025, Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 38(2) (2), 60 - 65, English, International magazine
    [Refereed]
    Scientific journal

  • Hideki Kanemoto, Tetsuo Kashibayashi, Ryuichi Takahashi, Takashi Suehiro, Yuto Satake, Daiki Taomoto, Yoshihiro Chadani, Kenji Tagai, Shunichiro Shinagawa, Kazunari Ishii, Kenji Yoshiyama, Manabu Ikeda, Hiroaki Kazui
    OBJECTIVES: This study identifies neuropsychiatric syndromes and investigates their relationship with neuroimaging in Alzheimer's disease dementia (AD), dementia with Lewy bodies (DLB), and mild cognitive impairment (MCI). METHODS: Magnetic resonance imaging and perfusion single-photon emission computed tomography data were collected for 281, 68, and 180 patients with AD, DLB, and MCI, respectively, from three Japanese institutions. Neuropsychiatric Inventory was used for exploratory factor analysis in each group. Statistical Parametric Mapping was exploited to reveal the relationships between each factor score and cerebral volume or perfusion with age, sex, dementia severity, and the other factor scores as covariates. RESULTS: Three factors (psychosis, agitation, and affective disturbance) were extracted for AD. For DLB, nighttime behavior and aberrant motor behavior were extracted as independent symptoms with the same three factors. Four factors (psychosis, agitation, anxiety, and apathy) were extracted for MCI. A positive relationship between agitation and cerebral volume in the left middle frontal gyri and left caudate was observed in AD. In DLB, agitation was positively correlated with cerebral perfusion in the left dominant regions, including the middle frontal gyri and caudate. Psychosis and perfusion were negatively correlated in the left extent regions, including the temporo-parieto-occipital lobe, insula, and inferior frontal gyri in DLB. Psychosis was significantly associated with lower perfusion in the bilateral occipital lobes, whereas apathy was significantly correlated with a lower volume of the right dominant bilateral frontal lobes in MCI. CONCLUSIONS: Three neuropsychiatric syndromes - psychosis, agitation, and affective disturbance - may heterogeneously associate with AD, DLB, and MCI.
    Mar. 2025, International psychogeriatrics, 37(3) (3), 100059 - 100059, English, International magazine
    Scientific journal

  • Masafumi Nishikawa, Akitoshi Takeda, Naotaka Miyazawa, Norikazu Hara, Kazunari Ishii, Takeshi Ikeuchi, Yoshiaki Itoh
    A 47-year-old man with a family history of juvenile dementia in his mother presented with memory loss and cognitive decline. Neuropsychological tests revealed impaired orientation, working memory, and apraxia. Magnetic resonance imaging revealed diffuse brain atrophy, and fluorodeoxyglucose positron emission tomography (PET) showed hypometabolism in the bilateral parietal lobes, posterior cingulate gyri, and precuneus, suggestive of Alzheimer's disease. However, amyloid-beta and tau PET scans were negative. Genetic testing revealed an abnormal repeat insertion in the prion protein gene, confirming inherited prion disease. This case highlights the need to consider inherited prion disease in the differential diagnosis of early-onset familial dementia.
    Mar. 2025, Internal medicine (Tokyo, Japan), English, Domestic magazine
    Scientific journal

  • Nobuo Kashiwagi, Atsushi Kawata, Mio Sakai, Hiroto Takahashi, Tomoko Hyodo, Hayato Kaida, Ken-ichi Yoshida, Satoshi Nojima, Satoshi Takenaka, Kazunari Ishii, Katsuyuki Nakanishi, Noriyuki Tomiyama
    Abstract Purpose To comprehensively summarize the magnetic resonance imaging (MRI) features of angiosarcomas presenting as Stewart-Treves syndrome (STS) through a retrospective case series and systematic review of previous publications. Materials and methods We identified five patients with STS from our institutional database and 25 patients with STS from 15 publications through a systemic review. We reviewed the MR features of 30 patients with STS, including five males and 25 females with a mean age of 59.5 years. Results The tumors most commonly involved both the cutis and subcutis (17/25, 68.0%); the remaining tumors were limited to the cutis or subcutis. Multiple tumors were observed in more than half of the cases (16/27, 59.3%), and most of the tumors had poorly defined margins (26/28, 92.9%). The most common signal intensities of the tumors on T1-weighted images were intermediate (16/19, 84.2%), and the remainder were a mixture of intermediate and high, with a predominance of intermediate signal intensity. The signal intensities of the tumors on T2-weighted images were intermediate in seven cases (7/13, 53.8%), a mixture of intermediate and high in five cases (5/13, 38.5%), and a mixture of intermediate and low in one case (1/13, 7.7%). Available diffusion-weighted images from four institutional cases showed restricted diffusion of the tumors with mean apparent diffusion coefficient (ADC) values ranging from 0.77 × 10−3 mm2/s to 0.96 × 10−3 mm2/s. Conclusion Typical MRI features of angiosarcomas in STS were superficially located in multiple masses with ill-defined margins. Internal signal intensity was intermediate on T1-weighted images, and intermediate or a mixture of intermediate and high on T2-weighted images. ADC values obtained from the limited number of cases were low.
    Springer Science and Business Media LLC, Feb. 2025, Japanese Journal of Radiology, 43(6) (6), 995 - 1006, English, Domestic magazine
    Scientific journal

  • Hirofumi Fujii, Hiroshi Toyama, Daiki Kayano, Kazunari Ishii, Seigo Kinuya
    The 13th World Federation of Nuclear Medicine and Biology congress (WFNMB 2022) was held in Kyoto and Kanazawa, Japan in September 2022, approximately half a century after the first World Congress of Nuclear Medicine held in Tokyo and Kyoto, Japan. In this paper, we describe the road to hosting another WFNMB congress in Japan, including the historic election for WFNMB 2022, the state of WFNMB 2022 in Kyoto, and the post-congress symposium in Kanazawa. This congress, themed "Summarize the past half century and discuss the next half century of WFNMB," was successful and strongly encouraged doctors and researchers to develop future research and clinical practice in nuclear medicine.
    Feb. 2025, Annals of nuclear medicine, 39(2) (2), 87 - 97, English, Domestic magazine
    Scientific journal

  • Chifumi Iseki, Kazunari Ishii, Nicolò G Pozzi, Massimiliano Todisco, Claudio Pacchetti
    INTRODUCTION: For the accurate diagnosis of idiopathic normal pressure hydrocephalus (iNPH) an accurate neuroimaging is essential. Disproportionately enlarged subarachnoid-space hydrocephalus (DESH) is a key neuroradiological feature and novel imaging techniques, including voxel-based morphometry and AI-assisted analyses are emerging as powerful tools to investigate iNPH pathophysiology. Converging evidence also suggests a role for dopaminergic dysfunction in iNPH. Molecular imaging of the dopamine transporter (DaT) enables the investigation of dopaminergic function and holds potential for advancing differential diagnosis and guiding treatment decisions in iNPH. EVIDENCE ACQUISITION: A comprehensive literature search was conducted using MeSH key words. Studies assessing the role of structural and functional neuroimaging in iNPH. The evidence was summarized, and key results were provided. EVIDENCE SYNTHESIS: DESH is crucial for accurate diagnosis and treatment planning. Advanced structural and functional imaging techniques are expanding our understanding of iNPH pathophysiology. Only few functional imaging studies have directly examined the dopaminergic dysfunction in iNPH and severe methodological limitations exist in both clinical classification and imaging processing. Nonetheless, evidence supports the presence of dopaminergic dysfunction in iNPH, which may be linked to specific clinical symptoms, aid in differential diagnosis, and be reversed with shunt surgery treatment. CONCLUSIONS: This review covers the structural and functional imaging data in iNPH, providing a comprehensive outlook of the current knowledge, highlighting the limitations and possible future perspectives.
    Feb. 2025, Journal of neurosurgical sciences, 69(1) (1), 64 - 78, English, International magazine
    Scientific journal

  • Daichi Sone, Iman Beheshti, Kenji Tagai, Hiroshi Kameyama, Emi Takasaki, Tetsuo Kashibayashi, Ryuichi Takahashi, Kazunari Ishii, Hideki Kanemoto, Manabu Ikeda, Masahiro Shigeta, Shunichiro Shinagawa, Hiroaki Kazui
    AIM: Despite the clinical importance and significant social burden of neuropsychiatric symptoms (NPS) in dementia, the underlying neurobiological mechanism remains poorly understood. Recently, neuroimaging-derived brain-age estimation by machine-learning analysis has shown promise as an individual-level biomarker. We investigated the relationship between NPS and brain-age in amnestic mild cognitive impairment (MCI) and early dementia. METHODS: In this cross-sectional study, clinical data, including neuropsychiatric inventory (NPI), and structural brain MRI of 499 individuals with clinical diagnoses of amnestic MCI (n = 185), early Alzheimer's disease (AD) (n = 258) or dementia with Lewy bodies (DLB) (n = 56) were analyzed. We established a brain-age prediction model using 694 healthy brain MRIs and a support vector regression model and applied it to the participants' data. Finally, the brain-predicted age difference (brain-PAD: predicted age minus chronological age) was calculated. RESULTS: All groups showed significantly increased brain-PAD, and the median (IQR) brain-PAD was 4.3 (5.4) years in MCI, 6.3 (6.2) years in AD, and 5.0 (6.5) years in DLB. The NPI scores were subdivided into the following four categories: (i) Agitation and Irritability, (ii) Depression and Apathy, (iii) Delusions and Hallucinations, and (iv) Euphoria and Disinhibition. We found a significantly positive correlation between brain-PAD and the depression/apathy factor (Spearman's rs = 0.156, FDR-corrected P = 0.002), whereas no significance was shown for the other NPS factors. CONCLUSION: Higher brain-age may be associated with depression and apathy symptoms presented in MCI to early dementia stages, and brain-age analysis may be useful as a novel biomarker for the assessment or monitoring of NPS.
    Jan. 2025, Psychiatry and clinical neurosciences, 79(4) (4), 158 - 164, English, International magazine
    Scientific journal

  • Riku Hasegawa, Takashi Nakata, Kazunari Ishii, Syoji Kobashi
    Elsevier BV, 2025, Procedia Computer Science, 270, 4978 - 4987
    Scientific journal

  • Kazuhiro Yoshiura, Yosuke Hidaka, Takashi Suehiro, Naoto Kajitani, Asuka Koyama, Yusuke Miyagawa, Naoko Tsunoda, Tomohisa Ishikawa, Ryuji Fukuhara, Mamoru Hashimoto, Manabu Ikeda, Megumi Shimodozono, Kazunari Ishii, Minoru Takebayashi
    Elsevier BV, 2025

  • Koichi Miyazaki, Takahiro Yamada, Hayato Kaida, Kohei Hanaoka, Kazunari Ishii
    Jan. 2025, Neuroradiology
    Scientific journal

  • 特発性正常圧水頭症の鑑別診断におけるMulti-Head AttentionとDiversify-Lossを用いた包括的脳全体アプローチの検討
    澤 風吹, 藤田 大輔, 嶋田 兼一, 石井 一成, 小橋 昌司
    バイオメディカル・ファジィ・システム学会, Dec. 2024, バイオメディカル・ファジィ・システム学会年次大会講演論文集, 37回, 104 - 104, Japanese

  • Yasuyuki Kojita, Nonoka Okada, Mayumi Hirakawa, Kanako Fujii, Takao Satou, Kazunari Ishii
    Dec. 2024, Radiology Case Reports
    Scientific journal

  • 小路田 泰之, 石井 一成
    (株)Gakken, Nov. 2024, 画像診断, 44(14) (14), 1417 - 1426, Japanese

  • Kazunari Ishii, Takahiro Yamada, Kohei Hanaoka, Hayato Kaida, Yasuyuki Kojita, Atsushi Kono, Kazushi Hanada, Kazumasa Saigoh, Shizuka Sakuta, Mamoru Hashimoto, Takashi Kato, Akinori Nakamura
    BACKGROUND: Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and tau proteins, leading to neurofibrillary tangles. A biomarker-based diagnostic method called the ATN system categorizes AD pathology into amyloid-β (A), tau (T), and neurodegeneration (N). The relationship between regional tau deposition and reduced glucose metabolism in the preclinical AD stage is not well understood. OBJECTIVE: We presented voxel-by-voxel metabolic/tau deposition ratio (MTR) images to investigate the effects of tau deposition on metabolism in AD brains on a stage-by-stage basis. METHODS: We selected 174 subjects who underwent 3D-MRI, FDG-PET, amyloid PET, and tau PET scans. MTR images were created by normalizing FDG-PET toMK6240 PET images. Voxel-wise comparisons among 63 cognitively normal amyloid-negative (CNA) subjects, 49 subjects with AD dementia (ADD), 23 subjects with mild cognitive impairment due to AD (MCA), and 39 preclinical AD (PRC) subjects were conducted. RESULTS: There was reduced glucose metabolism in ADD and MCA groups compared to CNA, predominantly in parietotemporal areas. Tau deposition was observed in wider areas in ADD and restricted to the medial temporal lobes in MCA. MTR exhibited significant reductions in broader regions in ADD and MCA, indicating simultaneous glucose metabolism decrease and tau deposition. At the MCA and PRC stages, glucose metabolism impairment and tau deposition were shown in separate regions by FDG PET and tau PET, respectively, while MTR images showed impairment in both regions. CONCLUSIONS: Our findings suggest that MTR imaging provides insights into AD pathophysiology by simultaneously assessing glucose metabolism and tau deposition. In the early stage of the AD continuum (MCA and PRC), metabolic decline and tau deposition occur independently in different brain regions.
    Nov. 2024, Journal of Alzheimer's disease : JAD, 102(1) (1), 228 - 236, English, International magazine
    Scientific journal

  • 血漿Aβ42/40とpTau 217の臨床的有用性の検討 測定安定性の検証
    中村 昭範, 徳田 隆彦, 加藤 隆司, 石井 一成, 石井 賢二, 二橋 尚志, 櫻井 圭太, 武田 章敬, 新畑 豊, 建部 陽嗣, 佐藤 朝巳, 山下 和人, 佐藤 利幸, 新飯田 俊平
    (一社)日本認知症学会, Oct. 2024, Dementia Japan, 38(4) (4), 678 - 678, Japanese

  • 液体塞栓物質(NBCA)を極める-NBCAを安全に使いこなす NBCAの特性を理解する NBCAを安全に使いこなすために
    岡田 卓也, 浦瀬 篤史, 谷 龍一郎, 杉本 幸司, 石井 一成
    (一社)日本脈管学会, Oct. 2024, 脈管学, 64(Suppl.) (Suppl.), S115 - S116, Japanese

  • 血漿Aβ42/40とpTau217の臨床的有用性の検討 Aβ病理及びTau病理との関連
    中村 昭範, 徳田 隆彦, 加藤 隆司, 石井 一成, 石井 賢二, 二橋 尚志, 櫻井 圭太, 武田 章敬, 新畑 豊, 建部 陽嗣, 佐藤 朝巳, 山下 和人, 佐藤 利幸, 新飯田 俊平
    (一社)日本認知症学会, Oct. 2024, Dementia Japan, 38(4) (4), 679 - 679, Japanese

  • Takahiro Yamada, Kohei Hanaoka, Daisuke Morimoto-Ishikawa, Yoshiyuki Yamakawa, Shiho Kumakawa, Atsushi Ohtani, Tetsuro Mizuta, Hayato Kaida, Kazunari Ishii
    BACKGROUND: Brain-dedicated positron emission tomography (PET) systems offer high spatial resolution and sensitivity for accurate clinical assessments. Attenuation correction (AC) is important in PET imaging, particularly in brain studies. This study assessed the reproducibility of attenuation maps (µ-maps) generated by a specialized time-of-flight (TOF) brain-dedicated PET system for imaging using different PET tracers. METHODS: Twelve subjects underwent both 18F-fluorodeoxyglucose (FDG)-PET and 18F-flutemetamol (FMM) amyloid-PET scans. Images were reconstructed with µ-maps obtained by a maximum likelihood-based AC method. Voxel-based and region-based analyses were used to compare µ-maps obtained with FDG-PET versus FMM-PET; FDG-PET images reconstructed using an FDG-PET µ-map (FDG × FDG) versus those reconstructed with an FMM-PET µ-map (FDG × FMM); and FMM-PET images reconstructed using an FDG-PET µ-map (FMM × FDG) versus those reconstructed with an FMM-PET µ-map (FMM × FMM). RESULTS: Small but significant differences in µ-maps were observed between tracers, primarily in bone regions. In the comparison between the µ-maps obtained with FDG-PET and FMM-PET, the µ-maps obtained with FDG-PET had higher µ-values than those obtained with FMM-PET in the parietal regions of the head and skull, in a portion of the cerebellar dentate nucleus and on the surface of the frontal lobe. The comparison between FDG and FDG × FMM values in different regions yielded findings similar to those of the µ-maps comparison. FDG × FMM values were significantly higher than FDG values in the bilateral temporal bones and a small part of the temporal lobe. Similarly, FMM values were significantly higher than FMM × FDG values in the bilateral temporal bones. FMM × FDG values were significantly higher than FMM values in a small area of the right cerebellar hemisphere. However, the relative errors in these µ-maps were within ± 4%, suggesting that they are clinically insignificant. In PET images reconstructed with the original and swapped µ-maps, the relative errors were within ± 7% and the quality was nearly equivalent. CONCLUSION: These findings suggest the clinical reliability of the AC method without an external radiation source in TOF brain-dedicated PET systems.
    Sep. 2024, Annals of nuclear medicine, English, Domestic magazine
    Scientific journal

  • Akinori Takenaka, Takashi Nihashi, Keita Sakurai, Keiji Notomi, Hokuto Ono, Yoshitaka Inui, Shinji Ito, Yutaka Arahata, Akinori Takeda, Kazunari Ishii, Kenji Ishii, Kengo Ito, Hiroshi Toyama, Akinori Nakamura, Takashi Kato
    Abstract Objective The purpose of this study was to validate the concordance of visual ratings of [18F] flutemetamol amyloid positron emission tomography (PET) images and to investigate the correlation between the agreement of each rater and the Centiloid (CL) scale. Methods A total of 192 participants, clinically classified as cognitively normal (CN) (n = 59), mild cognitive impairment (MCI) (n = 65), Alzheimer’s disease (AD) (n = 55), or non-AD dementia (n = 13), participated in this study. Three experts conducted visual ratings of the amyloid PET images for all 192 patients, assigning a confidence level to each rating on a three-point scale (certain, probable, or neither). The positive or negative determination of amyloid PET results was made by majority vote. The CL value was calculated using the CapAIBL pipeline. Results Overall, 101 images were determined to be positive, and 91 images were negative. Of the 101 positive images, the three raters were in complete agreement for 92 images and in disagreement for 9 images. Of the 91 negative images, the three raters were in complete agreement for 75 images and in disagreement for 16 images. Interrater reliability among the three experts was particularly high, with both Fleiss’ kappa and Conger’s kappa measuring 0.83 (0.76–0.89). The CL values of the unanimous positive group were significantly greater than those of the other groups, whereas the CL values of the unanimous negative group were significantly lower than those of the other groups. Images with rater disagreement had intermediate CLs. In cases with a high confidence level, the positive or negative visual ratings were in almost complete agreement. However, as confidence levels decreased, experts’ visual ratings became more variable. The lower the confidence level was, the greater the number of cases with disagreement in the visual ratings. Conclusion Three experts independently rated 192 amyloid PET images, achieving a high level of interrater agreement. However, in patients with intermediate amyloid accumulation, visual ratings varied. Therefore, determining positive and negative decisions in these patients should be performed with caution.
    Springer Science and Business Media LLC, Sep. 2024, Annals of Nuclear Medicine
    Scientific journal

  • Yoshihiro Chadani, Ryoko Fujito, Naohiro Kimura, Ryo Kawai, Tetsuo Kashibayashi, Ryuichi Takahashi, Hideki Kanemoto, Kazunari Ishii, Kenji Tagai, Shunichiro Shinagawa, Manabu Ikeda, Hiroaki Kazui
    Springer Science and Business Media LLC, Sep. 2024, Scientific Reports, 14(1) (1)
    Scientific journal

  • Mika Yamamuro, Yoshiyuki Asai, Takahiro Yamada, Yuichi Kimura, Kazunari Ishii, Yohan Kondo
    Springer Science and Business Media LLC, Sep. 2024, Medical & Biological Engineering & Computing
    Scientific journal

  • Yasuyuki Kojita, Atsushi K Kono, Takahiro Yamada, Minoru Yamada, Sung-Woon Im, Takenori Kozuka, Hayato Kaida, Motoi Kuwahara, Yoshitaka Nagai, Kazunari Ishii
    Symmetrical lesions in the temporal poles and external capsules on brain MRI are known as radiological markers of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL); however, similar imaging findings have also been reported in neuromyelitis optica spectrum disorder (NMOSD), and this study investigated the frequency of such findings. The study included 55 NMOSD patients who met the 2015 international NMO diagnosis panel (IPND) criteria and were positive for aquaporin-4 antibodies (AQP4-Ab). Images were evaluated based on the consensus of two neuroradiologists, and brain lesions were detected in 33 patients, of whom 2 (6%) had symmetrical lesions in both the temporal poles and external capsules, and 1 (3%) had symmetrical lesions confined to the external capsules. Therefore, when symmetrical lesions in the temporal poles and external capsules are observed on MRI, NMOSD should be considered in the differential diagnosis.
    Aug. 2024, Neuroradiology, English, International magazine
    Scientific journal

  • Yosuke Hidaka, Mamoru Hashimoto, Takashi Suehiro, Ryuji Fukuhara, Tomoisa Ishikawa, Naoko Tsunoda, Asuka Koyama, Kazuki Honda, Yusuke Miyagawa, Kazuhiro Yoshiura, Seiji Yuuki, Naoto Kajitani, Shuken Boku, Kazunari Ishii, Manabu Ikeda, Minoru Takebayashi
    Background Choroid plexus (CP) volume increase may be associated with cognitive decline in older individuals without dementia. In this study, we aimed to clarify whether CP volume can be an imaging marker of cognitive decline in older adults, verify its association with cognitive decline in older individuals compared with brain parenchymal and CSF volumes, and explore the factors associated with the CP volume. Methods We measured the CP volume, brain parenchyma, and cerebrospinal fluid (CSF) spaces associated with disproportionately enlarged subarachnoid space hydrocephalus (DESH), an imaging feature of normal-pressure hydrocephalus, in community-dwelling individuals aged ≥65 years without dementia. Results In 1,370 participants, lower Mini-Mental State Examination (MMSE) scores were significantly associated with higher CP volume, even after adjusting for DESH-related CSF space and brain parenchymal volume. CP volume was more strongly associated with MMSE scores than DESH-related CSF space and brain parenchymal volume. History of smoking, white matter hyperintensity, enlarged perivascular spaces, age, body mass index, and diabetes mellitus were associated with increased CP volume. Conclusions In community-dwelling older individuals without dementia, CP volume is associated with cognitive decline independent of the brain parenchyma and CSF volumes and may be one of the most sensitive imaging markers of cognitive decline. Our findings emphasize the importance of investigating CP volume increase to maintain cognitive function in older individuals. Further longitudinal studies are required.
    Cold Spring Harbor Laboratory, Aug. 2024, Fluids and barriers of the CNS, 21(1) (1), 101 - 101, English, International magazine
    Scientific journal

  • Daisuke Morimoto-Ishikawa, Tomoko Hyodo, Yoriaki Komeda, Hiroyuki Fukushima, Makoto Itoh, Yu Ueda, Masatoshi Kudo, Shigeyoshi Saito, Kazunari Ishii
    PURPOSE: The aim of this study was to investigate the utility of native T1 and T2 mapping in the bowel to evaluate disease activity in Crohn disease (CD) using endoscopy as the reference standard. METHODS: This was a prospective study. Magnetic resonance imaging was performed by using a 1.5-T Philips scanner. We used a modified look-locker inversion recovery and a multiecho gradient-spin-echo sequences for single breath-hold native T1 and T2 maps, respectively, for the short-axis image of the intestine, and the measurement at the most severe site was compared with partial Simple Endoscopic Score for Crohn's Disease (pSES-CD, assessed by an expert endoscopist). A pSES-CD ≥ 4 indicated active disease. Statistical analyses were performed using the Student t test, Spearman correlation, and receiver operating characteristic curve analysis. RESULTS: A total of 27 patients (mean age ± standard deviation, 37 ± 18 years; 20 men, 7 women) were included in this study. The native T1 value of active disease was significantly higher than that of inactive disease (1170.8 ± 100.5 milliseconds vs 924.5 ± 95.3 milliseconds; P = 0.018), but the T2 value was not significantly different between active and inactive disease (76.1 ± 7.8 milliseconds vs 69.3 ± 10.9 milliseconds; P = 0.424). A good correlation was found between native T1 value and pSES-CD (ρ = 0.71; P < 0.001) but not between T2 value and pSES-CD (ρ = 0.06; P = 0.790). The area under the receiver operating characteristic curve for differentiating the disease activity was 0.96 (95% confidence interval [CI]: 0.90-1.00) for T1 values and 0.68 (95% confidence interval: 0.41-0.96) for T2 values. CONCLUSIONS: Native T1 mapping could be potentially used as a noninvasive method to differentiate disease activity in patients with CD and may be superior to T2 mapping for this purpose.
    Aug. 2024, Journal of computer assisted tomography, English, International magazine
    Scientific journal

  • 脳MR画像におけるMulti-input CNNを用いた特発性正常圧水頭症の鑑別診断支援
    澤 風吹, 藤田 大輔, 嶋田 兼一, 石井 一成, 小橋 昌司
    (一社)日本医用画像工学会, Aug. 2024, 日本医用画像工学会大会予稿集, 43回, 206 - 207, Japanese

  • レビー小体型認知症における不安の神経基盤 脳血流SPECTを用いた分析
    木村 直広, 茶谷 佳宏, 河合 亮, 藤戸 良子, 鐘本 英輝, 高橋 竜一, 樫林 哲雄, 品川 俊一郎, 互 健二, 石井 一成, 池田 学, 數井 裕光
    日本神経心理学会, Aug. 2024, 日本神経心理学会総会プログラム・予稿集, 48回, 111 - 111, Japanese

  • レビー小体型認知症における不安の神経基盤 脳血流SPECTを用いた分析
    木村 直広, 茶谷 佳宏, 河合 亮, 藤戸 良子, 鐘本 英輝, 高橋 竜一, 樫林 哲雄, 品川 俊一郎, 互 健二, 石井 一成, 池田 学, 數井 裕光
    日本神経心理学会, Aug. 2024, 日本神経心理学会総会プログラム・予稿集, 48回, 111 - 111, Japanese

  • 脳MR画像におけるMulti-input CNNを用いた特発性正常圧水頭症の鑑別診断支援
    澤 風吹, 藤田 大輔, 嶋田 兼一, 石井 一成, 小橋 昌司
    (一社)日本医用画像工学会, Aug. 2024, 日本医用画像工学会大会予稿集, 43回, 66 - 66, Japanese

  • 脳MR画像におけるMulti-input CNNを用いた特発性正常圧水頭症の鑑別診断支援
    澤 風吹, 藤田 大輔, 嶋田 兼一, 石井 一成, 小橋 昌司
    (一社)日本医用画像工学会, Aug. 2024, 日本医用画像工学会大会予稿集, 43回, 206 - 207, Japanese

  • Hayato Kaida, Takaaki Chikugo, Hirokazu Tanaka, Kazunari Ishii
    A 60-year-old woman underwent whole-body contrast-enhanced CT because multiple myeloma was suspected. The contrast-enhanced CT showed pancreatic enlargement without main pancreatic duct dilatation and increased peripancreatic fat tissue. 18 F-FDG PET/CT demonstrated diffuse uptake in the enlargement of the pancreas, left and right ventricles, and vertebral column. Biopsy and bone marrow aspiration cytology revealed amyloid light-chain amyloidosis associated with multiple myeloma. Chemotherapy was performed; 18 F-FDG uptake in the pancreas then disappeared, and the pancreatic enlargement decreased. When diffuse 18 F-FDG uptake in pancreatic enlargement is observed in multiple myeloma patients, amyloid light-chain amyloidosis should be considered.
    Aug. 2024, Clinical nuclear medicine, 49(8) (8), 781 - 783, English, International magazine
    Scientific journal

  • Tetsuo Kashibayashi, Hideki Kanemoto, Ryuichi Takahashi, Ryoko Fujito, Yoshihiro Chadani, Kenji Tagai, Shunichiro Shinagawa, Kazunari Ishii, Manabu Ikeda, Hiroaki Kazui
    BACKGROUND: Aggression, a common symptom of Alzheimer's disease (AD), can impose a significant burden on caregivers, necessitating early institutionalization. OBJECTIVE: The current study examined the neural basis of aggression and its expression mechanism, to advance the development of effective treatment strategies for aggression in patients with AD. METHODS: The study sample included 257 patients; 180 were diagnosed with AD and 77 with amnestic mild cognitive impairment (aMCI). Factor analysis of the neuropsychiatric inventory (NPI) aggression scores was performed, and the correlation between each factor and cerebral blood flow (CBF) was examined via diagnosis of AD or aMCI using statistical parametric mapping. RESULTS: Refusal of care was correlated with reduced CBF in the right hippocampus of patients with AD while no specific related regions could be identified in patients with aMCI. Violent behavior was associated with decreased CBF in the right temporal pole and medial frontal lobe of patients with AD and aMCI. CONCLUSIONS: These findings suggest that aggression, measured using NPI includes two distinct symptoms, refusal of care and violent behavior, having different underlying neural bases.
    Jul. 2024, Journal of Alzheimer's disease : JAD, English, International magazine
    Scientific journal

  • Yasuyuki Kojita, Atsushi K Kono, Takahiro Yamada, Minoru Yamada, Sung-Woon Im, Takenori Kozuka, Hayato Kaida, Motoi Kuwahara, Yoshitaka Nagai, Kazunari Ishii
    PURPOSE: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are two major demyelinating diseases affecting the central nervous system (CNS). The objective of this study is to evaluate the prevalence of pontine trigeminal nerve lesions in patients diagnosed with MS and NMOSD using MRI. METHODS: This retrospective study included patients diagnosed with MS or NMOSD between July 2018 and July 2023. MS patients were clinically diagnosed using the 2017 McDonald criteria, while NMOSD patients were those who met the 2015 International Panel for NMO Diagnosis (IPND) criteria and were positive for Aquaporin-4 Antibody (AQP4-Ab). RESULTS: The study included a total of 90 patients, with 45 diagnosed with MS and another 45 with NMOSD. Pontine trigeminal nerve lesions were observed in both MS and NMOSD, but were more prevalent in MS patients (20 % vs. 2 %, p = 0.008). Root entry zone (REZ) lesions were found in 4 of 45 MS patients, accounting for 9 % (95 % CI: 3 %-17 %), and were absent in the NMOSD group; however, there was no significant difference between the two groups (p = 0.12). Of the MS patients with pontine trigeminal nerve lesions, 6 out of 9 (63 %; 95 % CI, 36 %-98 %) exhibited bilateral lesions, which was significantly more prevalent compared to the NMOSD group (13 % vs. 0 %, p = 0.03). CONCLUSIONS: The presence of pontine trigeminal nerve lesions, particularly when bilateral, are significantly more prevalent in MS patients than in those with NMOSD, suggesting their utility as a distinctive marker and potential diagnostic indicator specifically for MS.
    Jul. 2024, European journal of radiology, 178, 111597 - 111597, English, International magazine
    Scientific journal

  • Koji Sugimoto, Takahiro Yamada, Atsushi Kono, SungWoon Im, Kazunari Ishii
    Purpose: Our earlier investigation assessed the correlation between regional accumulations of a tau positron emission tomography (PET) tracer (THK5351) and cognitive dysfunction in the Alzheimer's disease (AD) continuum brain. We reported significant correlations between bilateral parietotemporal and left posterior cingulate/precuneus THK5351 accumulations and MiniMental State Examination (MMSE)/Alzheimer Disease Assessment Scale-Cognitive Subtest (ADAS) scores. Herein, we explored the relationship between these variables in non-AD pathologic brains. Methods: Thirty-one subjects with non-AD pathologic changes (mean age: 64.6±11.3 yrs) underwent three-dimensional MRI, fluoro-2-deoxyglucose (FDG)-(PET), Pittsburgh compound B (PiB)-amyloid PET, and THK5351-tau PET. All subjects completed the MMSE (mean±SD score: 27.0±4.1), and 20 subjects (mean age: 63.8±11.9 yrs) also completed the ADAS (9.7±9.3). A voxel-wise statistical analysis using statistical parametric mapping determined the correlations between each subject's FDG and THK imaging results and their MMSE and ADAS scores. Results: The voxel-wise statistical analysis revealed that FDG accumulations in the left temporal cortices were significantly positively correlated with the subjects' MMSE scores and significantly negatively correlated with their ADAS scores. A negative correlation was observed between the subjects' MMSE scores and THK5351 accumulations in the left temporal and medial frontal cortices and the right temporal pole. A positive correlation was observed between the subjects' ADAS scores and THK5351 accumulations in the left temporal cortices and the right anterior temporal lobe. Conclusions: Compared to FDG accumulation, THK5351 accumulations correlated more strongly with neuropsychological test scores in non-AD pathologic brains, likely due to THK5351's affinity for both tau and monoamine oxidase-B. THK5351 measurements may be valuable for clarifying the pathophysiology of non-AD pathologic changes in the brain.
    Jun. 2024, Acta Medica Kindai University, 49(1) (1), 1 - 6, English
    [Refereed]
    Scientific journal

  • Hiroyuki Fujii, Mitsuru Matsuki, Takefumi Hamakawa, Yumiko Toda, Nana Fujii, Sota Masuoka, Akihiro Nakamata, Emiko Chiba, Kazunari Ishii, Harushi Mori
    Hemochromatosis is a primary or secondary pathological condition characterized by the deposition of excess iron in the body tissues, which can eventually lead to cellular damage and organ dysfunction. Although excess iron deposition in the central nervous system is rare, involvement of the choroid plexus, pituitary gland, cortical surfaces, and basal ganglia has been reported to date. This case report describes 2 cases of transfusion-induced hemochromatosis involving the choroid plexus and pituitary gland, which were diagnosed by magnetic resonance imaging (MRI). In both cases, gradient echo (GRE) sequences, such as T2 star-weighted image and susceptibility-weighted imaging demonstrated markedly low signal intensity in the choroid plexus. Furthermore, the pituitary gland showed low signal intensity on T2-weighted images in Patient 2. Because these low signal intensities were not seen prior to red blood cell transfusion, they were diagnosed with transfusion-induced hemochromatosis. Brain MRI with GRE sequences was useful in detecting iron deposition in the choroid plexus. Considering that iron deposition in the body tissues can lead to irreversible organ damage, MRI with GRE sequences should be considered for patients with suspected iron overload.
    May 2024, Radiology Case Reports, 19(5) (5), 1666 - 1670, English, International magazine
    Scientific journal

  • Arata Segawa, Mitsutaka Nemoto, Hayato Kaida, Yuichi Kimura, Takashi Nagaoka, Katsuhiro Mikami, Takahiro Yamada, Kohei Hanaoka, Tatsuya Tsuchitani, Kazuhiro Kitajima, Kazunari Ishii
    SPIE, Apr. 2024, Medical Imaging 2024: Imaging Informatics for Healthcare, Research, and Applications
    International conference proceedings

  • Tomoya Ohsaka, Yasuyuki Kojita, Atsushi Urase, Ayumi Hirayama, Minoru Yamada, Sung-Woon Im, Atsushi K Kono, Yasuhiro Sanada, Takaaki Chikugo, Noboru Tanigawa, Kazunari Ishii
    Solitary fibrous tumor (SFT) is a rare interstitial tumor that originates from various soft tissues, and SFTs occurring within the cranium are extremely rare. While intracranial SFTs with cerebral hemorrhage or subarachnoid hemorrhage have been reported, there have been no reports of intracranial SFTs causing subdural hematoma. In this case, we report on an intracranial SFT accompanied by a subdural hematoma. A 29-year-old female was emergently transported due to the sudden onset of persistent headache and vomiting that began the night before. CT and MRI imaging revealed a hemorrhagic tumor under the tentorium and an acute subdural hematoma extending along the tentorium. The excised tumor was diagnosed as an SFT through histopathological examination. After undergoing radiation therapy, no recurrence has been observed. This is the first case report of an SFT accompanied by a subdural hematoma, and it is vital to recognize that SFTs can be associated with subdural hematomas for proper diagnosis and treatment planning.
    Apr. 2024, Cureus, 16(4) (4), e58271, English, International magazine

  • Cong Shang, Keita Sakurai, Takashi Nihashi, Yutaka Arahata, Akinori Takeda, Kazunari Ishii, Kenji Ishii, Hiroshi Matsuda, Kengo Ito, Takashi Kato, Hiroshi Toyama, Akinori Nakamura
    OBJECTIVE: The Centiloid (CL) scale is a standardized measure for quantifying amyloid deposition in amyloid positron emission tomography (PET) imaging. We aimed to assess the agreement among 3 CL calculation methods: CapAIBL, VIZCalc, and Amyquant. METHODS: This study included 192 participants (mean age: 71.5 years, range: 50-87 years), comprising 55 with Alzheimer's disease, 65 with mild cognitive impairment, 13 with non-Alzheimer's dementia, and 59 cognitively normal participants. All the participants were assessed using the three CL calculation methods. Spearman's rank correlation, linear regression, Friedman tests, Wilcoxon signed-rank tests, and Bland-Altman analysis were employed to assess data correlations, linear associations, method differences, and systematic bias, respectively. RESULTS: Strong correlations (rho = 0.99, p < .001) were observed among the CL values calculated using the three methods. Scatter plots and regression lines visually confirmed these strong correlations and met the validation criteria. Despite the robust correlations, a significant difference in CL value between CapAIBL and Amyquant was observed (36.1 ± 39.7 vs. 34.9 ± 39.4; p < .001). In contrast, no significant differences were found between CapAIBL and VIZCalc or between VIZCalc and Amyquant. The Bland-Altman analysis showed no observable systematic bias between the methods. CONCLUSIONS: The study demonstrated strong agreement among the three methods for calculating CL values. Despite minor variations in the absolute values of the Centiloid scores obtained using these methods, the overall agreement suggests that they are interchangeable.
    Mar. 2024, Annals of nuclear medicine, English, Domestic magazine
    Scientific journal

  • Taku Kotera, Masakatsu Tsurusaki, Ryohei Kozuki, Atsushi Urase, Ayumi Hirayama, Kazunari Ishii
    Retroportal artery is one of the communicating arteries between the hepatic artery and the superior mesenteric artery, but it is often a small artery and usually unrecognized. We report a 60-year-old man that was successfully treated for postpancreatectomy hemorrhage from the retroportal artery with compression of the celiac trunk by the median arcuate ligament. Following the pancreaticoduodenectomy, the bloody discharge was discovered through the drainage catheter. We underwent transcatheter arterial embolization for the bleeding from the retroportal artery associated with a postoperative pancreatic fistula. Additionally, because a stenosis of the common hepatic artery was discovered, we consequently installed a stent-graft on the common hepatic artery to prevent the liver failure due to decreased hepatic blood flow.
    Mar. 2024, Interventional radiology (Higashimatsuyama-shi (Japan), 9(1) (1), 36 - 40, English, Domestic magazine

  • Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, Ryozo Kuwano, Takeshi Iwatsubo, Akihiro Nakaya, Takeshi Ikeuchi, Michael W. Weiner, Sara S. Mason, Colleen S. Albers, David Knopman, Kris Johnson, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Beau Ances, John C. Morris, Maria Carroll, Mary L. Creech, Erin Franklin, Mark A. Mintun, Stacy Schneider, Angela Oliver, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina Carter, Sara Dolen, James Brewer, Helen Vanderswag, Adam Fleisher, Judith L. Heidebrink, Joanne L. Lord, Rachelle S. Doody, Javier Villanueva-Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Daniel Marson, Randall Griffith, David Clark, David Geldmacher, John Brockington, Erik Roberson, Marissa Natelson Love, Hillel Grossman, Effie Mitsis, Raj C. Shah, Leyla deToledo-Morrell, Ranjan Duara, Daniel Varon, Maria T. Greig, Peggy Roberts, Marilyn Albert, Chiadi Onyike, Daniel D’Agostino, Stephanie Kielb, James E. Galvin, Brittany Cerbone, Christina A. Michel, Dana M. Pogorelec, Henry Rusinek, Mony J. de Leon, Lidia Glodzik, Susan De Santi, P. Murali Doraiswamy, Jeffrey R. Petrella, Salvador Borges-Neto, Terence Z. Wong, Edward Coleman, Charles D. Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Anton P. Porsteinsson, Bonnie S. Goldstein, Kim Martin, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Ruth A. Mulnard, Gaby Thai, Catherine Mc-Adams-Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Liana Apostolova, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Jared R. Brosch, Scott Herring, Cynthia Hunt, Kathleen Tingus, Ellen Woo, Daniel H. S. Silverman, Po H. Lu, George Bartzokis, Neill R. Graff-Radford, Francine Parfitt, Tracy Kendall, Heather Johnson, Christopher H. van Dyck, Richard E. Carson, Martha G. MacAvoy, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Bojana Stefanovic, Curtis Caldwell, Ging-Yuek Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly, Elizabeth Finger, Stephen Pasternack, Irina Rachisky, Dick Trost, Andrew Kertesz, Charles Bernick, Donna Munic, Marek Marsel Mesulam, Kristine Lipowski, Sandra Weintraub, Borna Bonakdarpour, Diana Kerwin, Chuang-Kuo Wu, Nancy Johnson, Carl Sadowsky, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A. Sperling, Keith A. Johnson, Gad Marshall, Jerome Yesavage, Joy L. Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N. Sabbagh, Christine M. Belden, Sandra A. Jacobson, Sherye A. Sirrel, Neil Kowall, Ronald Killiany, Andrew E. Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O. Obisesan, Saba Wolday, Joanne Allard, Alan Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, Evan Fletcher, Pauline Maillard, John Olichney, Charles DeCarli, Owen Carmichael, Smita Kittur, Michael Borrie, T.-Y. Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia M. Carlsson, Steven G. Potkin, Adrian Preda, Dana Nguyen, Pierre Tariot, Anna Burke, Nadira Trncic, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W. Scharre, Maria Kataki, Anahita Adeli, Earl A. Zimmerman, Dzintra Celmins, Alice D. Brown, Godfrey D. Pearlson, Karen Blank, Karen Anderson, Laura A. Flashman, Marc Seltzer, Mary L. Hynes, Robert B. Santulli, Kaycee M. Sink, Leslie Gordineer, Jeff D. Williamson, Pradeep Garg, Franklin Watkins, Brian R. Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J. Rosen, Bruce L. Miller, David Perry, Jacobo Mintzer, Kenneth Spicer, David Bachman, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Norman Relkin, Gloria Chaing, Michael Lin, Lisa Ravdin, Amanda Smith, Balebail Ashok Raj, Kristin Fargher, Takashi Asada, Hiroyuki Arai, Morihiro Sugishita, Hiroshi Matsuda, Noriko Sato, Hajime Sato, Kengo Ito, Teruhiko Kachi, Kenji Toba, Michio Senda, Kenji Ishii, Shun Shimohama, Masaki Saitoh, Rika Yamauchi, Takashi Hayashi, Chiyoko Takanami, Seiju Kobayashi, Norihito Nakano, Junichiro Kanazawa, Takeshi Ando, Masato Hareyama, Masamitsu Hatakenaka, Eriko Tsukamoto, Shinji Ochi, Mikio Shoji, Etsuro Matsubara, Takeshi Kawarabayashi, Yasuhito Wakasaya, Takashi Nakata, Naoko Nakahata, Shuichi Ono, Yoshihiro Takai, Satoshi Takahashi, Hisashi Yonezawa, Junko Takahashi, Masako Kudoh, Kuniko Ueno, Hiromi Sakashita, Kuniko Watanabe, Makoto Sasaki, Yutaka Matsumura, Yohsuke Hirata, Tsuyoshi Metoki, Susumu Hayakawa, Yuichi Sato, Masayuki Takeda, Koichiro Sera, Kazunori Terasaki, Toshiaki Sasaki, Yoshihiro Saitoh, Shoko Goto, Ken Nagata, Tetsuya Maeda, Yasushi Kondoh, Takashi Yamazaki, Daiki Takano, Mio Miyata, Hiromi Komatsu, Mayumi Watanabe, Tomomi Sinoda, Rena Muraoka, Kayoko Kikuchi, Hitomi Ito, Aki Sato, Toshibumi Kinoshita, Hideyo Toyoshima, Kaoru Sato, Shigeki Sugawara, Isao Ito, Fumiko Kumagai, Katsutoshi Furukawa, Masaaki Waragai, Naoki Tomita, Mari Ootsuki, Katsumi Sugawara, Satomi Sugawara, Nobuyuki Okamura, Shunji Mugikura, Atsushi Umetsu, Takanori Murata, Tatsuo Nagasaka, Yukitsuka Kudo, Manabu Tashiro, Shoichi Watanuki, Masatoyo Nishizawa, Takayoshi Tokutake, Saeri Ishikawa, Emiko Kishida, Nozomi Sato, Mieko Hagiwara, Kumi Yamanaka, Takeyuki Watanabe, Taeko Takasugi, Shoichi Inagawa, Kenichi Naito, Masanori Awaji, Tsutomu Kanazawa, Kouiti Okamoto, Masaki Ikeda, Yuiti Tasiro, Syunn Nagamine, Sathiko Kurose, Tsuneo Yamazaki, Shiori Katsuyama, Sayuri Fukushima, Etsuko Koya, Makoto Amanuma, Kouiti Ujita, Kazuhiro Kishi, Kazuhisa Tuda, Noboru Oriuti, Katsuyoshi Mizukami, Tetsuaki Arai, Etsuko Nakajima, Katsumi Miyamoto, Tomoya Kobayashi, Saori Itoya, Jun Ookubo, Toshiya Akatsu, Yoshiko Anzai, Junya Ikegaki, Yuuichi Katou, Kaori Kimura, Hajime Saitou, Kazuya Shinoda, Satoka Someya, Hiroko Taguchi, Kazuya Tashiro, Masaya Tanaka, Tatsuya Nemoto, Ryou Wakabayashi, Daisuke Watanabe, Kousaku Saotome, Ryou Kuchii, Harumasa Takano, Tetsuya Suhara, Hitoshi Shinoto, Hitoshi Shimada, Makoto Higuchi, Takaaki Mori, Hiroshi Ito, Takayuki Obata, Yoshiko Fukushima, Kazuko Suzuki, Izumi Izumida, Katsuyuki Tanimoto, Takahiro Shiraishi, Hitoshi Shinotoh, Junko Shiba, Hiroaki Yano, Miki Satake, Aimi Nakui, Yae Ebihara, Tomomi Hasegawa, Yasumasa Yoshiyama, Mami Kato, Yuki Ogata, Hiroyuki Fujikawa, Nobuo Araki, Yoshihiko Nakazato, Takahiro Sasaki, Tomokazu Shimadu, Kimiko Yoshimaru, Etsuko Imabayashi, Asako Yasuda, Keiko Ozawa, Etuko Yamamoto, Natsumi Nakamata, Noriko Miyauchi, Rieko Hashimoto, Taishi Unezawa, Takafumi Ichikawa, Hiroki Hayashi, Masakazu Yamagishi, Tunemichi Mihara, Masaya Hirano, Shinichi Watanabe, Junichiro Fukuhara, Hajime Matsudo, Nobuyuki Saito, Atsushi Iwata, Hisatomo Kowa, Toshihiro Hayashi, Ryoko Ihara, Toji Miyagawa, Mizuho Yoshida, Yuri Koide, Eriko Samura, Kurumi Fujii, Kaori Watanabe, Nagae Orihara, Toshimitsu Momose, Miwako Takahashi, Takuya Arai, Yoshiki Kojima, Akira Kunimatsu, Harushi Mori, Masami Goto, Takeo Sarashina, Syuichi Uzuki, Seiji Katou, Yoshiharu Sekine, Yukihiro Takauchi, Chiine Kagami, Kazutomi Kanemaru, Yasushi Nishina, Maria Sakaibara, Yumiko Okazaki, Rieko Okada, Maki Obata, Masaki Takao, Yuko Iwata, Mizuho Minami, Yasuko Hanabusa, Hanae Shingyouji, Kyoko Tottori, Aya Tokumaru, Makoto Ichinose, Kazuya Kume, Syunsuke Kahashi, Kunimasa Arima, Shin Tanaka, Yuko Nagahusa, Masuhiro Sakata, Mitsutoshi Okazaki, Maki Yamada, Tadashi Tukamoto, Tiine Kodama, Tomoko Takeuchi, Keiichiro Ozawa, Yoshiko Kawaji, Kyouko Tottori, Yasuhiro Nakata, Satoshi Sawada, Makoto Mimatsu, Daisuke Nakkamura, Takeshi Tamaru, Shunichirou Horiuchi, Heii Arai, Tsuneyoshi Ota, Aiko Kodaka, Yuko Tagata, Tomoko Nakada, Eizo Iseki, Kiyoshi Sato, Hiroshige Fujishiro, Norio Murayama, Masaru Suzuki, Satoshi Kimura, Masanobu Takahashi, Haruo Hanyu, Hirofumi Sakurai, Takahiko Umahara, Hidekazu Kanetaka, Kaori Arashino, Mikako Murakami, Ai Kito, Seiko Miyagi, Kaori Doi, Kazuyoshi Sasaki, Mineo Yamazaki, Akiko Ishiwata, Yasushi Arai, Akane Nogami, Sumiko Fukuda, Koichi Kozaki, Yukiko Yamada, Sayaka Kimura, Ayako Machida, Kuninori Kobayashi, Hidehiro Mizusawa, Nobuo Sanjo, Mutsufusa Watanabe, Takuya Ohkubo, Hiromi Utashiro, Yukiko Matsumoto, Kumiko Hagiya, Yoshiko Miyama, Hitoshi Shibuya, Isamu Ohashi, Akira Toriihara, Takako Shinozaki, Haruko Hiraki, Shinichi Ohtani, Toshifumi Matsui, Tomomi Toyama, Hideki Sakurai, Kumiko Sugiura, Yu Hayasaka, Hirofumi Taguchi, Shizuo Hatashita, Akari Imuta, Akiko Matsudo, Daichi Wakebe, Hideki Hayakawa, Mitsuhiro Ono, Takayoshi Ohara, Yukihiko Washimi, Yutaka Arahata, Akinori Takeda, Akiko Yamaoka, Masashi Tsujimoto, Takiko Kawai, Ai Honda, Yoko Konagaya, Hideyuki Hattori, Kenji Yoshiyama, Rina Miura, Takashi Sakurai, Miura Hisayuki, Hidetoshi Endou, Syousuke Satake, Young Jae Hong, Katsunari Iwai, Masaki Suenaga, Sumiko Morita, Kengo Itou, Takashi Kato, Ken Fujiwara, Rikio Katou, Mariko Koyama, Naohiko Fukaya, Akira Tsuji, Hitomi Shimizu, Hiroyuki Fujisawa, Tomoko Nakazawa, Satoshi Koyama, Takanori Sakata, Masahito Yamada, Mitsuhiro Yoshita, Miharu Samuraki, Kenjiro Ono, Moeko Shinohara, Yuki Soshi, Kozue Niwa, Chiaki Doumoto, Mariko Hata, Miyuki Matsushita, Mai Tsukiyama, Nozomi Takeda, Sachiko Yonezawa, Ichiro Matsunari, Osamu Matsui, Fumiaki Ueda, Yasuji Ryu, Masanobu Sakamoto, Yasuomi Ouchi, Yumiko Fujita, Madoka Chita, Rika Majima, Hiromi Tsubota, Umeo Shirasawa, Masashi Sugimori, Wataru Ariya, Yuuzou Hagiwara, Yasuo Tanizaki, Hidenao Fukuyama, Shizuko Tanaka-Urayama, Shin-Ichi Urayama, Ryosuke Takahashi, Kengo Uemura, Hajime Takechi, Chihiro Namiki, Takeshi Kihara, Hiroshi Yamauchi, Emiko Maeda, Natsu Saito, Shiho Satomi, Konomi Kabata, Tomohisa Okada, Koichi Ishizu, Shigeto Kawase, Satoshi Fukumoto, Masanori Nakagawa, Masaki Kondo, Fumitoshi Niwa, Toshiki Mizuno, Yoko Oishi, Mariko Yamazaki, Daisuke Yamaguchi, Takahiko Tokuda, Kyoko Ito, Yoku Asano, Chizuru Hamaguchi, Kei Yamada, Chio Okuyama, Kentaro Akazawa, Shigenori Matsushima, Takamasa Matsuo, Toshiaki Nakagawa, Takeshi Nii, Takuji Nishida, Kuniaki Kiuchi, Masami Fukusumi, Hideyuki Watanabe, Toshiaki Taoka, Akihiro Nogi, Masatoshi Takeda, Toshihisa Tanaka, Hiroaki Kazui, Takashi Kudo, Masayasu Okochi, Takashi Morihara, Shinji Tagami, Masahiko Takaya, Tamiki Wada, Mikiko Yokokoji, Hiromichi Sugiyama, Daisuke Yamamoto, Keiko Nomura, Mutsumi Tomioka, Naoyuki Sato, Noriyuki Hayashi, Shuko Takeda, Eiichi Uchida, Yoshiyuki Ikeda, Mineto Murakami, Takami Miki, Hiroyuki Shimada, Suzuka Ataka, Akitoshi Takeda, Yuki Iwamoto, Motokatsu Kanemoto, Jun Takeuchi, Rie Azuma, Naomi Tagawa, Junko Masao, Yuka Matsumoto, Yuko Kikukawa, Hisako Fujii, Junko Matsumura, Susumu Shiomi, Joji Kawabe, Yoshihiro Shimonishi, Mitsuji Higashida, Tomohiro Sahara, Takashi Yamanaga, Yukio Miki, Shinichi Sakamoto, Hiroyuki Tsushima, Kiyoshi Maeda, Yasuji Yamamoto, Kazuo Sakai, Haruhiko Oda, Yoshihiko Tahara, Toshio Kawamata, Taichi Akisaki, Mizuho Adachi, Masako Kuranaga, Sachi Takegawa, Seishi Terada, Yuki Kishimoto, Naoya Takeda, Nao Imai, Mayumi Yabe, Reiko Wada, Takeshi Ishihara, Hajime Honda, Osamu Yokota, Kentaro Ida, Daigo Anami, Seiji Inoue, Toshi Matsushita, Shinsuke Hiramatsu, Hiromi Tonbara, Reiko Yamamoto, Kenji Nakashima, Kenji Wada-Isoe, Saori Yamasaki, Eijiro Yamashita, Yu Nakamura, Ichiro Ishikawa, Sonoko Danjo, Tomomi Shinohara, Yuka Kashimoto, Miyuki Ueno, Yoshihiro Nishiyama, Yuka Yamamoto, Narihide Kimura, Kazuo Ogawa, Yasuhiro Sasakawa, Takashi Ishimori, Yukito Maeda, Tatsuo Yamada, Shinji Ouma, Aika Fukuhara-Kaneumi, Nami Sakamoto, Rie Nagao, Kengo Yoshimitsu, Yasuo Kuwabara, Ryuji Nakamuta, Minoru Tanaka, Manabu Ikeda, Yuusuke Yatabe, Mamoru Hashimoto, Keiichirou Kaneda, Kazuki Honda, Naoko Ichimi, Mariko Morinaga, Miyako Noda, Fumi Akatuka, Mika Kitajima, Toshinori Hirai, Shinya Shiraishi, Naoji Amano, Shinsuke Washizuka, Tetsuya Hagiwara, Yatsuka Okada, Tomomi Ogihara, Toru Takahashi, Shin Inuzuka, Nobuhiro Sugiyama, Takehiko Yasaki, Minori Kitayama, Tomonori Owa, Akiko Ryokawa, Rie Takeuchi, Satoe Goto, Keiko Yamauchi, Mie Ito, Tomoki Kaneko, Hitoshi Ueda, Shuichi Ikeda, Ban Mihara, Hirofumi Kubo, Akiko Takano, Gou Yasui, Masami Akuzawa, Kaori Yamaguchi, Toshinari Odawara, Naomi Oota, Megumi Shimamura, Mikiko Sugiyama, Atsushi Watanabe, Shigeo Takebayashi, Yoshigazu Hayakawa, Mitsuhiro Idegawa, Noriko Toya, Kazunari Ishii
    Abstract Background Polygenic effects have been proposed to account for some disease phenotypes; these effects are calculated as a polygenic risk score (PRS). This score is correlated with Alzheimer’s disease (AD)-related phenotypes, such as biomarker abnormalities and brain atrophy, and is associated with conversion from mild cognitive impairment (MCI) to AD. However, the AD PRS has been examined mainly in Europeans, and owing to differences in genetic structure and lifestyle, it is unclear whether the same relationships between the PRS and AD-related phenotypes exist in non-European populations. In this study, we calculated and evaluated the AD PRS in Japanese individuals using genome-wide association study (GWAS) statistics from Europeans. Methods In this study, we calculated the AD PRS in 504 Japanese participants (145 cognitively unimpaired (CU) participants, 220 participants with late mild cognitive impairment (MCI), and 139 patients with mild AD dementia) enrolled in the Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI) project. In order to evaluate the clinical value of this score, we (1) determined the polygenic effects on AD in the J-ADNI and validated it using two independent cohorts (a Japanese neuropathology (NP) cohort (n = 565) and the North American ADNI (NA-ADNI) cohort (n = 617)), (2) examined the AD-related phenotypes associated with the PRS, and (3) tested whether the PRS helps predict the conversion of MCI to AD. Results The PRS using 131 SNPs had an effect independent of APOE. The PRS differentiated between CU participants and AD patients with an area under the curve (AUC) of 0.755 when combined with the APOE variants. Similar AUC was obtained when PRS calculated by the NP and NA-ADNI cohorts was applied. In MCI patients, the PRS was associated with cerebrospinal fluid phosphorylated-tau levels (β estimate = 0.235, p value = 0.026). MCI with a high PRS showed a significantly increased conversion to AD in APOE ε4 noncarriers with a hazard rate of 2.22. In addition, we also developed a PRS model adjusted for LD and observed similar results. Conclusions We showed that the AD PRS is useful in the Japanese population, whose genetic structure is different from that of the European population. These findings suggest that the polygenicity of AD is partially common across ethnic differences.
    Springer Science and Business Media LLC, Feb. 2024, Alzheimer's Research & Therapy, 16(1) (1)
    [Refereed]
    Scientific journal

  • Hiroshi Kameyama, Kenji Tagai, Emi Takasaki, Tetsuo Kashibayashi, Ryuichi Takahashi, Hideki Kanemoto, Kazunari Ishii, Manabu Ikeda, Masatoshi Shigeta, Shunichiro Shinagawa, Hiroaki Kazui
    BACKGROUND: Neuropsychiatric symptoms (NPS) in patients with dementia lead to caregiver burdens and worsen the patient's prognosis. Although many neuroimaging studies have been conducted, the etiology of NPS remains complex. We hypothesize that brain structural asymmetry could play a role in the appearance of NPS. OBJECTIVE: This study explores the relationship between NPS and brain asymmetry in patients with Alzheimer's disease (AD). METHODS: Demographic and MRI data for 121 mild AD cases were extracted from a multicenter Japanese database. Brain asymmetry was assessed by comparing the volumes of gray matter in the left and right brain regions. NPS was evaluated using the Neuropsychiatric Inventory (NPI). Subsequently, a comprehensive assessment of the correlation between brain asymmetry and NPS was conducted. RESULTS: Among each NPS, aggressive NPS showed a significant correlation with asymmetry in the frontal lobe, indicative of right-side atrophy (r = 0.235, p = 0.009). This correlation remained statistically significant even after adjustments for multiple comparisons (p <  0.01). Post-hoc analysis further confirmed this association (p <  0.05). In contrast, no significant correlations were found for other NPS subtypes, including affective and apathetic symptoms. CONCLUSIONS: The study suggests frontal lobe asymmetry, particularly relative atrophy in the right hemisphere, may be linked to aggressive behaviors in early AD. These findings shed light on the neurobiological underpinnings of NPS, contributing to the development of potential interventions.
    Feb. 2024, Journal of Alzheimer's disease : JAD, English, International magazine
    Scientific journal

  • Tetsuya Kobayashi, Yui Shigeki, Yoshiyuki Yamakawa, Yumi Tsutsumida, Tetsuro Mizuta, Kohei Hanaoka, Shota Watanabe, Daisuke Morimoto‑Ishikawa, Takahiro Yamada, Hayato Kaida, Kazunari Ishii
    Springer Science and Business Media LLC, Jan. 2024, Journal of Imaging Informatics in Medicine
    Scientific journal

  • 甲斐田 勇人, 花岡 宏平, 山田 穣, 任 誠雲, 山田 誉大, 小路田 泰之, 吉岡 宏真, 奥田 武司, 石井 一成
    (一社)日本核医学会, 2024, 核医学, 61(1) (1), 48 - 49, Japanese

  • Fubuki Sawa, Daisuke Fujita, Kenichi Shimada, Kazunari Ishii, Syoji Kobashi
    2024, 2024 Joint 13th International Conference on Soft Computing and Intelligent Systems and 25th International Symposium on Advanced Intelligent Systems, SCIS and ISIS 2024
    International conference proceedings

  • [18F]flutemetamol PETの視覚判定とCentiloid scaleの関係
    竹中 章倫, 二橋 尚志, 櫻井 圭太, 納冨 恵至, 小野 北斗, 石井 一成, 石井 賢二, 乾 好貴, 伊藤 健吾, 中村 昭範, 加藤 隆司
    (一社)日本核医学会, 2024, 核医学, 61(Suppl.) (Suppl.), S151 - S151, Japanese

  • 甲斐田 勇人, 花岡 宏平, 山田 穣, 任 誠雲, 山田 誉大, 小路田 泰之, 吉岡 宏真, 奥田 武司, 石井 一成
    (一社)日本核医学会, 2024, 核医学, 61(1) (1), 48 - 49, Japanese

  • Hitoshi HABE, Yuken YOSHIOKA, Daichi IKEFUJI, Tomokazu FUNATSU, Takashi NAGAOKA, Takenori KOZUKA, Mitsutaka NEMOTO, Takahiro YAMADA, Yuichi KIMURA, Kazunari ISHII
    Japanese Society for Medical and Biological Engineering, 2024, Advanced Biomedical Engineering, 13, 327 - 334
    Scientific journal

  • Kazunari Ishii
    BACKGROUND: Focal nodular hyperplasia (FNH)-like lesions are hyperplastic formations in patients with micronodular cirrhosis and a history of alcohol abuse. Although pathologically similar to hepatocellular carcinoma (HCC) lesions, they are benign. As such, it is important to develop methods to distinguish between FNH-like lesions and HCC. AIM: To evaluate diagnostically differential radiological findings between FNH-like lesions and HCC. METHODS: We studied pathologically confirmed FNH-like lesions in 13 patients with alcoholic cirrhosis [10 men and 3 women; mean age: 54.5 ± 12.5 (33-72) years] who were negative for hepatitis-B surface antigen and hepatitis-C virus antibody and underwent dynamic computed tomography (CT) and magnetic resonance imaging (MRI), including superparamagnetic iron oxide (SPIO) and/or gadoxetic acid-enhanced MRI. Seven patients also underwent angiography-assisted CT. RESULTS: The evaluated lesion features included arterial enhancement pattern, washout appearance (low density compared with that of surrounding liver parenchyma), signal intensity on T1-weighted image (T1WI) and T2-weighted image (T2WI), central scar presence, chemical shift on in- and out-of-phase images, and uptake pattern on gadoxetic acid-enhanced MRI hepatobiliary phase and SPIO-enhanced MRI. Eleven patients had multiple small lesions (< 1.5 cm). Radiological features of FNH-like lesions included hypervascularity despite small lesions, lack of "corona-like" enhancement in the late phase on CT during hepatic angiography (CTHA), high-intensity on T1WI, slightly high- or iso-intensity on T2WI, no signal decrease in out-of-phase images, and complete SPIO uptake or incomplete/partial uptake of gadoxetic acid. Pathologically, similar to HCC, FNH-like lesions showed many unpaired arteries and sinusoidal capillarization. CONCLUSION: Overall, the present study showed that FNH-like lesions have unique radiological findings useful for differential diagnosis. Specifically, SPIO- and/or gadoxetic acid-enhanced MRI and CTHA features might facilitate differential diagnosis of FNH-like lesions and HCC.
    Dec. 2023, World journal of gastroenterology, 31(2) (2), 98031 - 98031, English, International magazine
    Scientific journal

  • MCIおよび早期AD/DLBにおける脳年齢と神経精神症状の関連性 多施設共同研究
    曽根 大地, 互 健二, 品川 俊一郎, 樫林 哲雄, 高橋 竜一, 石井 一成, 鐘本 英輝, 池田 学, 繁田 雅弘, 數井 裕光
    (一社)日本認知症学会, Oct. 2023, Dementia Japan, 37(4) (4), 670 - 670, Japanese

  • 亀山 洋, 互 健二, 高崎 恵美, 樫林 哲雄, 高橋 竜一, 鐘本 英輝, 石井 一成, 池田 学, 繁田 雅弘, 品川 俊一郎, 數井 裕光
    (株)ワールドプランニング, Oct. 2023, 老年精神医学雑誌, 34(増刊II) (増刊II), 197 - 197, Japanese

  • 片上 茂樹, 鐘本 英輝, 垰本 大喜, 佐竹 祐人, 末廣 聖, 佐藤 俊介, 竹田 佳世, 吉山 顕次, 樫林 哲雄, 高橋 竜一, 互 健二, 品川 俊一郎, 石井 一成, 數井 裕光, 池田 学
    (株)ワールドプランニング, Oct. 2023, 老年精神医学雑誌, 34(増刊II) (増刊II), 197 - 197, Japanese

  • 片上 茂樹, 鐘本 英輝, 垰本 大喜, 佐竹 祐人, 末廣 聖, 佐藤 俊介, 竹田 佳世, 吉山 顕次, 樫林 哲雄, 高橋 竜一, 互 健二, 品川 俊一郎, 石井 一成, 數井 裕光, 池田 学
    (株)ワールドプランニング, Oct. 2023, 老年精神医学雑誌, 34(増刊II) (増刊II), 197 - 197, Japanese

  • MCIおよび早期AD/DLBにおける脳年齢と神経精神症状の関連性 多施設共同研究
    曽根 大地, 互 健二, 品川 俊一郎, 樫林 哲雄, 高橋 竜一, 石井 一成, 鐘本 英輝, 池田 学, 繁田 雅弘, 數井 裕光
    (一社)日本認知症学会, Oct. 2023, Dementia Japan, 37(4) (4), 670 - 670, Japanese

  • 亀山 洋, 互 健二, 高崎 恵美, 樫林 哲雄, 高橋 竜一, 鐘本 英輝, 石井 一成, 池田 学, 繁田 雅弘, 品川 俊一郎, 數井 裕光
    (株)ワールドプランニング, Oct. 2023, 老年精神医学雑誌, 34(増刊II) (増刊II), 197 - 197, Japanese

  • Takashi Nakata, Kenichi Shimada, Akiko Iba, Haruhiko Oda, Akira Terashima, Yutaka Koide, Ryota Kawasaki, Takahiro Yamada, Kazunari Ishii
    Abstract Purpose Predicting progression of mild cognitive impairment (MCI) to Alzheimer’s disease (AD) or dementia with Lewy bodies (DLB) is important. We evaluated morphological and functional differences between MCI with Lewy bodies (MCI-LB) and MCI due to AD (MCI-AD), and a method for differentiating between these conditions using brain MRI and brain perfusion SPECT. Methods A continuous series of 101 subjects, who had visited our memory clinic and met the definition of MCI, were enrolled retrospectively. They were consisted of 60 MCI-LB and 41 MCI-AD subjects. Relative cerebral blood flow (rCBF) on SPECT images and relative brain atrophy on MRI images were evaluated. We performed voxel-based analysis and visually inspected brain perfusion SPECT images for regional brain atrophy, occipital hypoperfusion and the cingulate island sign (CIS), for differential diagnosis of MCI-LB and MCI-AD. Results MRI showed no significant differences in regional atrophy between the MCI-LB and MCI-AD groups. In MCI-LB subjects, occipital rCBF was significantly decreased compared with MCI-AD subjects (p < 0.01, family wise error [FWE]-corrected). Visual inspection of occipital hypoperfusion had sensitivity, specificity, and accuracy values of 100%, 73.2% and 89.1%, respectively, for differentiating MCI-LB and MCI-AD. Occipital hypoperfusion was offered higher diagnostic utility than the CIS. Conclusions The occipital lobe was the region with significantly decreased rCBF in MCI-LB compared with MCI-AD subjects. Occipital hypoperfusion on brain perfusion SPECT may be a more useful imaging biomarker than the CIS for visually differentiating MCI-LB and MCI-AD.
    Oct. 2023, Japanese Journal of Radiology, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Hiroki Masuda, Masahiro Mori, Shigeki Hirano, Akiyuki Uzawa, Tomohiko Uchida, Mayumi Muto, Ryohei Ohtani, Reiji Aoki, Yoshiyuki Hirano, Satoshi Kuwabara
    We aimed to compare longitudinal brain atrophy in patients with neuromyelitis optica spectrum disorder (NMOSD) with healthy controls (HCs). The atrophy rate in patients with anti-aquaporin-4 antibody-positive NMOSD (AQP4 + NMOSD) was compared with age-sex-matched HCs recruited from the Japanese Alzheimer's Disease Neuroimaging Initiative study and another study performed at Chiba University. Twenty-nine patients with AQP4 + NMOSD and 29 HCs were enrolled in the study. The time between magnetic resonance imaging (MRI) scans was longer in the AQP4 + NMOSD group compared with the HCs (median; 3.2 vs. 2.9 years, P = 0.009). The annualized normalized white matter volume (NWV) atrophy rate was higher in the AQP4 + NMOSD group compared with the HCs (median; 0.37 vs. - 0.14, P = 0.018). The maximum spinal cord lesion length negatively correlated with NWV at baseline MRI in patients with AQP4 + NMOSD (Spearman's rho =  - 0.41, P = 0.027). The annualized NWV atrophy rate negatively correlated with the time between initiation of persistent prednisolone usage and baseline MRI in patients with AQP4 + NMOSD (Spearman's rho =  - 0.43, P = 0.019). Patients with AQP4 + NMOSD had a greater annualized NWV atrophy rate than HCs. Suppressing disease activity may prevent brain atrophy in patients with AQP4 + NMOSD.
    Aug. 2023, Scientific reports, 13(1) (1), 12631 - 12631, English, International magazine
    Scientific journal

  • 異所性静脈瘤の治療戦略 十二指腸静脈瘤の血行動態とIVR治療
    鶴崎 正勝, 小寺 卓, 上月 瞭平, 浦瀬 篤史, 逢坂 友也, 松井 繁長, 杉本 幸司, 石井 一成, 工藤 正俊
    (一社)日本門脈圧亢進症学会, Aug. 2023, 日本門脈圧亢進症学会雑誌, 29(3) (3), 73 - 73, Japanese

  • アルツハイマー型認知症患者における抑うつに対する病態失認の神経基盤について
    末廣 聖, 鐘本 英輝, 垰夲 大喜, 佐竹 祐人, 佐藤 俊介, 片上 茂樹, 竹田 佳世, 吉山 顕次, 樫林 哲雄, 高橋 竜二, 互 健二, 品川 俊一郎, 石井 一成, 數井 裕光, 池田 学
    日本神経心理学会, Aug. 2023, 日本神経心理学会総会プログラム・予稿集, 47回, 109 - 109, Japanese

  • 異所性静脈瘤の治療戦略 十二指腸静脈瘤の血行動態とIVR治療
    鶴崎 正勝, 小寺 卓, 上月 瞭平, 浦瀬 篤史, 逢坂 友也, 松井 繁長, 杉本 幸司, 石井 一成, 工藤 正俊
    (一社)日本門脈圧亢進症学会, Aug. 2023, 日本門脈圧亢進症学会雑誌, 29(3) (3), 73 - 73, Japanese

  • アルツハイマー型認知症における虚再認の脳内基盤の検討
    茶谷 佳宏, 藤戸 良子, 木村 直広, 河合 亮, 樫林 哲雄, 高橋 竜一, 鐘本 英輝, 互 健二, 品川 俊一郎, 石井 一成, 池田 学, 數井 裕光
    日本神経心理学会, Aug. 2023, 日本神経心理学会総会プログラム・予稿集, 47回, 127 - 127, Japanese

  • アルツハイマー病および健忘性軽度認知障害では易刺激性と島皮質の血流低下が関連する
    高橋 竜一, 樫林 哲雄, 鐘本 英輝, 池田 学, 石井 一成, 互 健二, 品川 俊一郎, 數井 裕光
    日本神経心理学会, Aug. 2023, 日本神経心理学会総会プログラム・予稿集, 47回, 137 - 137, Japanese

  • アルツハイマー型認知症患者における抑うつに対する病態失認の神経基盤について
    末廣 聖, 鐘本 英輝, 垰山 大喜, 佐竹 祐人, 佐藤 俊介, 片上 茂樹, 竹田 佳世, 吉山 顕次, 樫林 哲雄, 高橋 竜二, 互 健二, 品川 俊一郎, 石井 一成, 數井 裕光, 池田 学
    日本神経心理学会, Aug. 2023, 日本神経心理学会総会プログラム・予稿集, 47回, 109 - 109, Japanese

  • Hayato Kaida, Kazuhiro Kitajima, Tetsuro Sekine, Kimiteru Ito, Hiromitsu Daisaki, Takayuki Kimura, Mitsuo P Sato, Akifumi Enomoto, Naoki Otsuki, Kazunari Ishii
    OBJECTIVES: To investigate the usefulness of harmonized 18F-FDG-PET/CT parameters for predicting the postoperative recurrence and prognosis of oral tongue squamous cell carcinoma (OTSCC). METHODS: We retrospectively analyzed the cases of 107 OTSCC patients who underwent surgical resection at four institutions in Japan in 2010-2016 and evaluated the harmonized PET parameters of the maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) for the primary tumor as the pSUVmax, pMTV, and pTLG. For lymph node metastasis, we used harmonized PET parameters of nodal-SUVmax, nodal-total MTV (tMTV), and nodal-total TLG (tTLG). The associations between the harmonized PET parameters and the patients' relapse-free survival (RFS) and overall survival (OS) were evaluated by the Kaplan-Meier method and Cox proportional hazard regression analysis for model 1 (preoperative stage) and model 2 (preoperative   +  postoperative stages). RESULTS: The harmonized SUVmax values were significantly lower than those before harmonization (p=0.012). The pSUVmax was revealed as a significant preoperative risk factor for RFS and OS. Nodal-SUVmax, nodal-tMTV, and nodal-tTLG were significant preoperative risk factors for OS. The combination of pSUVmax + nodal-SUVmax significantly stratified the patients into a low-risk group (pSUVmax <3.97 + nodal-SUVmax <2.85 or ≥2.85) and a high-risk group (pSUVmax ≥3.97 + nodal-SUVmax <2.85 or pSUVmax ≥3.97 + nodal-SUVmax ≥2.85) for recurrence and prognosis (RFS: p=0.001; OS: p<0.001). CONCLUSIONS: The harmonized pSUVmax is a significant prognostic factor for the survival of OTSCC patients. The combination of pSUVmax and nodal-SUVmax identified OTSCC patients at high risk for recurrence and poor prognosis at the preoperative stage.
    Jul. 2023, Dento maxillo facial radiology, 20230083 - 20230083, English, International magazine
    Scientific journal

  • Shota Watanabe, Yuki Kono, Shigetoshi Kitaguchi, Hiroyuki Kosaka, Kazunari Ishii
    We aimed to evaluate the image quality of brain computed tomography (CT) images reconstructed using deep learning-based reconstruction (DLR) in organ-based tube current modulation (OB-TCM) acquisition. An anthropomorphic head phantom and a cylindrical low-contrast phantom were scanned at the standard dose level for adult brain CT in axial volume acquisition without OB-TCM. Moreover, image acquisition with OB-TCM was performed. The radiation dose on the eye lens was measured using a scintillation fibre-optic dosimeter placed on the anthropomorphic phantom's eye surface. The task transfer function (TTF), contrast-to-noise ratio (CNR), and low-contrast object specific CNR obtained from low-contrast phantom images reconstructed with filtered back projection (FBP), hybrid iterative reconstruction (HIR), and two types of DLR (DLRCTA and DLRLCD) were compared. In result, OB-TCM achieved a 32.5% dose reduction in the eye lens. Although HIR, DLRCTA, and DLRLCD showed lower TTF than FBP, the difference in TTF at the highest contributing spatial frequency corresponding to the contrast rod diameter was < 10%. Despite the OB-TCM acquisition, DLRCTA and DLRLCD achieved significantly lower noise and a higher CNR than FBP without OB-TCM (p < 0.05). However, low-contrast object specific CNR was equivalent among all reconstruction methods for the objective diameter of 5 mm and slightly improved in DLRLCD for the objective diameter of 7 mm. DLR with OB-TCM acquisition enabled dose reduction for the eye lens and high CNR image appearance, whereas the low contrast detectability evaluated by low-contrast object specific CNR did not always improve.
    Springer Science and Business Media LLC, Jun. 2023, Physical and Engineering Sciences in Medicine, 46(3) (3), 1153 - 1162, English, International magazine
    Scientific journal

  • Akira Hamada, Kazuhiro Kitajima, Kenichi Suda, Takamasa Koga, Junichi Soh, Hayato Kaida, Kimiteru Ito, Tetsuro Sekine, Kyoshiro Takegahara, Hiromitsu Daisaki, Masaki Hashimoto, Yukihiro Yoshida, Takanobu Kabasawa, Takashi Yamasaki, Seiichi Hirota, Jitsuo Usuda, Kazunari Ishii, Tetsuya Mitsudomi
    OBJECTIVES: Despite the prognostic impacts of preoperative fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography examination, fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography-based prognosis prediction has not been used clinically because of the disparity in data between institutions. By applying an image-based harmonized approach, we evaluated the prognostic roles of fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography parameters in clinical stage I non-small cell lung cancer. METHODS: We retrospectively examined 495 patients with clinical stage I non-small cell lung cancer who underwent fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography examinations before pulmonary resection between 2013 and 2014 at 4 institutions. Three different harmonization techniques were applied, and an image-based harmonization, which showed the best-fit results, was used in the further analyses to evaluate the prognostic roles of fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography parameters. RESULTS: Cutoff values of image-based harmonized fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography parameters, maximum standardized uptake, metabolic tumor volume, and total lesion glycolysis were determined using receiver operating characteristic curves that distinguish pathologic high invasiveness of tumors. Among these parameters, only the maximum standardized uptake was an independent prognostic factor in recurrence-free and overall survivals in univariate and multivariate analyses. High image-based maximum standardized uptake value was associated with squamous histology or lung adenocarcinomas with higher pathologic grades. In subgroup analyses defined by ground-glass opacity status and histology or by clinical stages, the prognostic impact of image-based maximum standardized uptake value was always the highest compared with other fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography parameters. CONCLUSIONS: The image-based fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography harmonization was the best fit, and the image-based maximum standardized uptake was the most important prognostic marker in all patients and in subgroups defined by ground-glass opacity status and histology in surgically resected clinical stage I non-small cell lung cancers.
    Jun. 2023, JTCVS open, 14, 502 - 522, English, International magazine
    Scientific journal

  • 当院における難治性腹水に対するデンバーシャントの有用性
    浦瀬 篤史, 鶴崎 正勝, 小寺 卓, 上月 暸平, 平山 歩, 石井 一成, 青木 智子, 工藤 正俊
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2023, 日本インターベンショナルラジオロジー学会雑誌, 38(Suppl.) (Suppl.), 143 - 143, Japanese

  • 胃静脈瘤に対するCANDISを用いたB-RTOの中期成績と肝予備能温存における効果
    小寺 卓, 鶴崎 正勝, 浦瀬 篤史, 上月 瞭平, 平山 歩, 石井 一成, 青木 智子, 工藤 正俊
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2023, 日本インターベンショナルラジオロジー学会雑誌, 38(Suppl.) (Suppl.), 216 - 216, Japanese

  • 内頸静脈アプローチで留置したCVポートにおけるカテーテル断裂のリスクファクターの検討
    上月 瞭平, 鶴崎 正勝, 浦瀬 篤史, 小寺 卓, 平山 歩, 石井 一成
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2023, 日本インターベンショナルラジオロジー学会雑誌, 38(Suppl.) (Suppl.), 224 - 224, Japanese

  • Yoko Satoh, Kohei Hanaoka, Chihiro Ikegawa, Masamichi Imai, Shota Watanabe, Daisuke Morimoto-Ishikawa, Hiroshi Onishi, Toshikazu Ito, Yoshifumi Komoike, Kazunari Ishii
    The performances of photomultiplier tube (PMT)-based dedicated breast positron emission tomography (PET) and silicon photomultiplier tube (SiPM)-based time-of-flight (TOF) PET, which is applicable not only to breast imaging but also to head imaging, were compared using a phantom study. A cylindrical phantom containing four spheres (3–10 mm in diameter) filled with 18F-FDG at two signal-to-background ratios (SBRs), 4:1 and 8:1, was scanned. The phantom images, which were reconstructed using three-dimensional list-mode dynamic row-action maximum likelihood algorithm with various β-values and post-smoothing filters, were visually and quantitatively compared. Visual evaluation showed that the 3 mm sphere was more clearly visualized with higher β and smaller post-filters, while the background was noisier; SiPM-based TOF-PET was superior to PMT-based dbPET in sharpness, smoothness, and detectability, although the background was noisier at the SBR of 8:1. Quantitative evaluation revealed that the detection index (DI) and recovery coefficient (CRC) of SiPM-based TOF-PET images were higher than those of PMT-based PET images, despite a higher background coefficient of variation (CVBG). The two organ-specific PET systems showed that a 3 mm lesion in the breast could be visualized at the center of the detector, and there was less noise in the SiPM-based TOF-PET image.
    MDPI AG, Mar. 2023, Diagnostics, 13(6) (6), 1079 - 1079, English, International magazine
    Scientific journal

  • Kohei Hanaoka, Shota Watanabe, Daisuke Ishikawa, Hayato Kaida, Takahiro Yamada, Masakazu Yasuda, Yoshitaka Iwanaga, Gaku Nakazawa, Kazunari Ishii
    Background The aim of this study was to estimate the impact of respiratory and electrocardiogram (ECG)-gated FDG positron emission tomography (PET)/computed tomography (CT) on the diagnosis of cardiac sarcoidosis (CS). Methods and Results Imaging from thirty-one patients was acquired on a PET/CT scanner equipped with a respiratory- and ECG-gating system. Non-gated PET images and three kinds of gated PET/CT images were created from identical list-mode clinical PET data: respiratory-gated PET during expiration (EX), ECG-gated PET at end diastole (ED), and ECG-gated PET at end systole (ES). The maximum standardized uptake value (SUVmax) and cardiac metabolic volume (CMV) were measured, and the locations of FDG accumulation were analyzed using a polar map. The mean SUVmax of the subjects was significantly higher after application of either respiratory-gated or ECG-gated reconstruction. Conversely, the mean CMV was significantly lower following the application of respiratory-gated or ECG-gated reconstruction. The segment showing maximum accumulation was shifted to the adjacent segment in 25.8%, 38.7%, and 41.9% of cases in EX, ED, and ES images, respectively. Conclusion In FDG PET/CT scanning for the diagnosis of CS, gated scanning is likely to increase quantitative accuracy, but the effect depends on the location and synchronization method.
    Mar. 2023, Journal of Nuclear Cardiology, 30(5) (5), 1879 - 1885, English, International magazine
    [Refereed]
    Scientific journal

  • 当院における急性上腸間膜動脈閉塞症に対するIVR治療経験
    浦瀬 篤史, 鶴崎 正勝, 小寺 卓, 上月 瞭平, 平山 歩, 石井 一成, 岩本 博司, 重岡 宏和
    (一社)日本腹部救急医学会, Feb. 2023, 日本腹部救急医学会雑誌, 43(2) (2), 408 - 408, Japanese

  • Hayato Kaida, Yuko Matsukubo, Sung-Woon Im, Nobuo Kashiwagi, Kazunari Ishii
    Ovid Technologies (Wolters Kluwer Health), Jan. 2023, Clinical Nuclear Medicine, Publish Ahead of Print
    Scientific journal

  • Kazunari Ishii, Kohei Hanaoka, Shota Watanabe, Daisuke Morimoto-Ishikawa, Takahiro Yamada, Hayato Kaida, Yoshiyuki Yamakawa, Suzuka Minagawa, Shiho Takenouchi, Atsushi Ohtani, Tetsuro Mizuta
    We acquired brain positron emission tomography (PET) images of fluorodeoxyglucose (FDG) and flutemetamol PET using a time-of-flight-PET system dedicated for the head (dhPET) and a conventional whole-body PET/computed tomography (wbPET) system and evaluated the clinical superiority of dhPET over wbPET. Methods: There were 18 subjects for the FDG-PET study and 17 subjects for the flutemetamol PET study. FDG-PET images were first obtained using wbPET, followed by dhPET. Flutemetamol PET images were first obtained using wbPET, followed by dhPET. Images acquired using dhPET and wbPET were compared by visual inspection, voxel-wise analysis, and standard uptake value ratio (SUVR). Results: All FDG and flutemetamol images acquired using dhPET were judged as better by visual inspection than those acquired using wbPET. The voxel-wise analysis demonstrated that accumulations in the cerebellum, lateral occipital cortices, and around the central sulcus area in dhPET FDG images were lower than those in wbPET FDG images, whereas accumulations around the ventricle systems were higher in dhPET FDG images than those in wbPET FDG images. Accumulations in the cerebellar dentate nucleus, midbrain, lateral occipital cortices, and around the central sulcus area in dhPET images were lower than those in wbPET images, whereas accumulations around the ventricle systems were higher in dhPET flutemetamol images than those in wbPET flutemetamol images. Mean cortical SUVRs of FDG and flutemetamol dhPET images were significantly higher than those of FDG and flutemetamol wbPET images, respectively. Conclusion: The dhPET images had better image quality by visual inspection and higher SUVRs than wbPET images. Although there were several regional accumulation differences between dhPET and wbPET images, understanding this phenomenon will enable full use of the features of this dhPET system in clinical practice.
    Jan. 2023, Journal of nuclear medicine : official publication, Society of Nuclear Medicine, English, International magazine
    Scientific journal

  • FlutemetamolアミロイドPETの中央読影における読影者間一致率の検討
    加藤 隆司, 納富 恵至, 小野 北斗, 石井 賢二, 石井 一成, 岩田 香織, 櫻井 圭太, 二橋 尚志, 中村 昭範, BATON Study Group
    (一社)日本核医学会, 2023, 核医学, 60(Suppl.) (Suppl.), S191 - S191, Japanese

  • Hayato Kaida, Miyuki Wakana, Sawa Yoshida, Yuko Matsukubo, Kazunari Ishii
    A 48-year-old man with an intermittent fever of 39.0oC for more than three weeks underwent computed tomography (CT) and blood testing, which revealed no clues. Antibiotics wereadministered, but his condition did not improve. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) showed right-lobe-dominant diffuse thyroid uptake. On technetium-99m (99mTc) pertechnetate scintigraphy, the thyroid gland could not be visualized, and he was diagnosed with subacute thyroiditis (SAT). When asymmetric 18F-FDG diffuse thyroid uptake on PET/CT is observed in a patient with a fever of unknown origin (FUO), SAT may need to be considered.
    2023, Hellenic journal of nuclear medicine, 26(2) (2), 150 - 154, English, International magazine
    Scientific journal

  • Kohei Hanaoka, Shota Watanabe, Daisuke Ishikawa, Kazunari Ishii
    2023, Nihon Hoshasen Gijutsu Gakkai zasshi, 79(1) (1), 90 - 96, Japanese, Domestic magazine
    Scientific journal

  • Inada M, Nishimura Y, Hanaoka K, Nakamatsu K, Doi H, Uehara T, Komanishi M, Ishii K, Kaida H, Hosono M
    BACKGROUND AND PURPOSE: In this study, fluoromisonidazole positron emission tomography (F-MISO PET/CT) was used to evaluate tumor hypoxia and re-oxygenation in patients with lung tumors treated with stereotactic body radiation therapy (SBRT). MATERIALS AND METHODS: Patients with T1-2 N0 lung cancer were included in this study. The prescribed dose was 48-52 Gy in four fractions. F-MISO PET/CT was performed twice, before SBRT and 1-3 days after the first irradiation. The maximum standardized uptake value (SUVmax) and tumor/muscle ratio (TMR) were evaluated as indicators of hypoxia. The threshold for hypoxia was defined as a TMR of 1.30 or more. RESULTS: Between 2016 and 2021, 15 patients were included. Pre-treatment tumor hypoxia was observed in nine tumors (60 %). TMR in all six tumors without pre-treatment hypoxia rose after single high-dose irradiation. In contrast, TMR in six of nine tumors with pre-treatment hypoxia dropped after irradiation, suggesting re-oxygenation. Although no local recurrence was noted, regional and/or distant relapses were seen in four patients (27 %). Of these, three had tumors with abnormal F-MISO uptake. The remaining patient had a tumor without signs of hypoxia on pre-treatment PET/CT. The 2-year progression free survival of patients with tumors with and without pre-treatment hypoxia were 30 % and 63 %, respectively (p = 0.319). CONCLUSION: Tumor hypoxia reduced after single high-dose irradiation. Tumor with F-MISO uptake seems to be an unfavorable prognostic factor in lung SBRT.
    Jan. 2023, Radiotherapy and Oncology, In press, 109491 - 109491, English, International magazine
    [Refereed]
    Scientific journal

  • Daisuke Morimoto-Ishikawa, Kohei Hanaoka, Shota Watanabe, Takahiro Yamada, Yoshiyuki Yamakawa, Suzuka Minagawa, Shiho Takenouchi, Atsushi Ohtani, Tetsuro Mizuta, Hayato Kaida, Kazunari Ishii
    BACKGROUND: This study evaluated the physical performance of a positron emission tomography (PET) system dedicated to the head and breast according to the National Electrical Manufacturers Association (NEMA) NU2-2012 standard. METHODS: The spatial resolution, sensitivity, scatter fraction, count rate characteristics, corrections for count losses and randoms, and image quality of the system were determined. All measurements were performed according to the NEMA NU2-2012 acquisition protocols, but image quality was assessed using a brain-sized phantom. Furthermore, scans of the three-dimensional (3D) Hoffmann brain phantom and mini-Derenzo phantom were acquired to allow visual evaluation of the imaging performance for small structures. RESULTS: The tangential, radial, and axial full width at half maximum (FWHM) at a 10-mm offset in half the axial field of view were measured as 2.3, 2.5, and 2.9 mm, respectively. The average system sensitivity at the center of the field of view and at a 10-cm radial offset was 7.18 and 8.65 cps/kBq, respectively. The peak noise-equivalent counting rate was 35.2 kcps at 4.8 kBq/ml. The corresponding scatter fraction at the peak noise-equivalent counting rate was 46.8%. The peak true rate and scatter fraction at 8.6 kBq/ml were 127.8 kcps and 54.3%, respectively. The percent contrast value for a 10-mm sphere was approximately 50%. On the 3D Hoffman brain phantom image, the structures of the thin layers composing the phantom were visualized on the sagittal and coronal images. On the mini-Derenzo phantom, each of the 1.6-mm rods was clearly visualized. CONCLUSION: Taken together, these results indicate that the head- and breast-dedicated PET system has high resolution and is well suited for clinical PET imaging.
    Dec. 2022, EJNMMI physics, 9(1) (1), 88 - 88, English, International magazine
    Scientific journal

  • Eiko Nishioka, Masakatsu Tsurusaki, Ryohei Kozuki, Sung-Woon Im, Atsushi Kono, Kazuhiro Kitajima, Takamichi Murakami, Kazunari Ishii
    We aimed to examine the accuracy of tumor staging of intrahepatic cholangiocarcinoma (ICC) by using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET-CT). From January 2001 to December 2021, 202 patients underwent PET-CT, CT, and MRI for the initial staging of ICC in two institutions. Among them, 102 patients had undergone surgical treatment. Ninety patients who had a histopathological diagnosis of ICC were retrospectively reviewed. The sensitivity and specificity of 18F-FDG PET-CT, CT, and magnetic resonance imaging (MRI) in detecting tumors, satellite focus, vascular invasion, and lymph node metastases were analyzed. Ninety patients with histologically diagnosed ICC were included. PET-CT demonstrated no statistically significant advantage over CT and MR in the diagnosis of multiple tumors and macrovascular invasion, and bile duct invasion. The overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET-CT in lymph node metastases were 84%, 86%, 91%, 84%, and 86%, respectively. PET-CT revealed a significantly higher accuracy compared to CT or MRI (86%, 67%, and 76%, p < 0.01, respectively) in the diagnosis of regional lymph node metastases. The accuracy of tumor staging by PET-CT was higher than that by CT/MRI (PET-CT vs. CT vs. MRI: 68/90 vs. 47/90 vs. 51/90, p < 0.05). 18F-FDG PET-CT had sensitivity and specificity values for diagnosing satellite focus and vascular and bile duct invasion similar to those of CT or MRI; however, PET-CT showed higher accuracy in diagnosing regional lymph node metastases. 18F-FDG PET-CT exhibited higher tumor staging accuracy than that of CT/MRI. Thus, 18FDG PET-CT may support tumor staging in ICC.
    Nov. 2022, Diagnostics (Basel, Switzerland), 12(11) (11), English, International magazine
    Scientific journal

  • Hayato Kaida, Takushi Yasuda, Osamu Shiraishi, Hiroaki Kato, Yutaka Kimura, Kohei Hanaoka, Minoru Yamada, Yuko Matsukubo, Masakatsu Tsurusaki, Kazuhiro Kitajima, Satoshi Hattori, Kazunari Ishii
    BACKGROUND: Induction or adjuvant therapies are not always beneficial for thoracic esophageal squamous cell carcinoma (ESCC) patients, and it is thus important to identify patients at high risk for postoperative ESCC recurrence. We investigated the usefulness of the total metabolic tumor volume (TMTV) for predicting the postoperative recurrence of thoracic ESCC. METHODS: We retrospectively analyzed the cases of 163 thoracic ESCC patients (135 men, 28 women; median age of 66 [range 34-82] years) treated at our hospital in 2007-2012. The TMTV was calculated from the fluorine-18 fluorodeoxyglucose (18F-FDG) uptake in the primary lesion and lymph node metastases. The optimal cut-off values for relapse and non-relapse were obtained by the time-dependent receiver operating curve analyses. Relapse-free survival (RFS) was evaluated by the Kaplan-Meier method, and between-subgroup differences in survival were analyzed by log-rank test. The prognostic significance of metabolic parameters and clinicopathological variables was assessed by a Cox proportional hazard regression analysis. The difference in the failure patterns after surgical resection was evaluated using the χ2-test. RESULTS: The optimal cut-off value of TMTV for discriminating relapse from non-relapse was 3.82. The patients with a TMTV ≥3.82 showed significantly worse prognoses than those with low values (p < 0.001). The TMTV was significantly related to RFS (model 1 for preoperative risk factors: TMTV: hazard ratio [HR] =2.574, p = 0.004; model 2 for preoperative and postoperative risk factors: HR = 1.989, p = 0.044). The combination of the TMTV and cN0-1 or pN0-1 stage significantly stratified the patients into low-and high-risk recurrence groups (TMTV cN0-1, p < 0.001; TMTV pN0-1, p = 0.004). The rates of hematogenous and regional lymph node metastasis were significantly higher in the patients with TMTV ≥3.82 than those with low values (hematogenous metastasis, p < 0.001, regional lymph node metastasis, p = 0.011). CONCLUSIONS: The TMTV was a more significantly independent prognostic factor for RFS than any other PET parameter in patients with resectable thoracic ESCC. The TMTV may be useful for the identifying thoracic ESCC patients at high risk for postoperative recurrence and for deciding the patient management.
    Nov. 2022, BMC cancer, 22(1) (1), 1176 - 1176, English, International magazine
    Scientific journal

  • Shota Watanabe, Kenta Sakaguchi, Shigetoshi Kitaguchi, Kazunari Ishii
    Nov. 2022, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 104, 1 - 9, English, International magazine
    Scientific journal

  • Tetsuro Mizuta, Yoshiyuki Yamakawa, Suzuka Minagawa, Tetsuya Kobayashi, Atsushi Ohtani, Shiho Takenouchi, Kohei Hanaoka, Shota Watanabe, Daisuke Morimoto-Ishikawa, Takahiro Yamada, Hayato Kaida, Kazunari Ishii
    OBJECTIVES: This study evaluates the phantom attenuation correction (PAC) method as an alternative to maximum-likelihood attenuation correction factor (ML-ACF) correction in time-of-flight (TOF) brain positron emission tomography (PET) studies. METHODS: In the PAC algorithm, a template emission image [Formula: see text] and a template attenuation coefficient image [Formula: see text] are prepared as a data set based on phantom geometry. Position-aligned attenuation coefficient image [Formula: see text] is derived by aligning [Formula: see text] using parameters that match the template emission image [Formula: see text] to measured emission image [Formula: see text]. Then, attenuation coefficient image [Formula: see text] combined with a headrest image is used for scatter and attenuation correction in the image reconstruction. To evaluate the PAC algorithm as an alternative to ML-ACF, Hoffman 3D brain and cylindrical phantoms were measured to obtain the image quality indexes of contrast and uniformity. These phantoms were also wrapped with a radioactive sheet to obtain attenuation coefficient images using ML-ACF. Emission images were reconstructed with attenuation correction by PAC and ML-ACF, and the results were compared using contrast and uniformity as well as visual assessment. CT attenuation correction (CT-AC) was also applied as a reference. RESULTS: The contrast obtained by ML-ACF was slightly overestimated due to its unique experimental condition for applying ML-ACF in Hoffman 3D brain phantom but the uniformity was almost equivalent among ML-ACF, CT-AC, and PAC. PAC showed reasonable result without overestimation compared to ML-ACF and CT-AC. CONCLUSIONS: PAC is an attenuation correction method that can ensure the performance in phantom test, and is considered to be a reasonable alternative to clinically used ML-ACF-based attenuation correction.
    Nov. 2022, Annals of nuclear medicine, 36(11) (11), 998 - 1006, English, Domestic magazine
    Scientific journal

  • Yosuke Hidaka, Mamoru Hashimoto, Takashi Suehiro, Ryuji Fukuhara, Tomohisa Ishikawa, Naoko Tsunoda, Asuka Koyama, Kazuki Honda, Yusuke Miyagawa, Kazuhiro Yoshiura, Shuken Boku, Kazunari Ishii, Manabu Ikeda, Minoru Takebayashi
    BACKGROUND: Impaired cerebrospinal fluid (CSF) dynamics may contribute to the pathophysiology of neurodegenerative diseases, and play a crucial role in brain health in older people; nonetheless, such age-related changes have not been well elucidated. Disproportionately enlarged subarachnoid-space hydrocephalus (DESH) is a neuroimaging phenotype of idiopathic normal-pressure hydrocephalus, originating from impaired CSF dynamics, and closely associated with aging. This study aimed to investigate the pathophysiology of DESH and determine age-related changes in CSF dynamics. METHODS: Using magnetic resonance imaging, we investigated the pathophysiology of DESH by quantitatively evaluating the volumes of DESH-related regions (ventricles [VS], Sylvian fissure [SF], and subarachnoid spaces at high convexity and midline [SHM]) and brain parenchyma in community-dwelling individuals aged  ≥ 65 years. DESH-related regions were assessed using a visual rating scale, and volumes measured using voxel-based morphometry. Brain parenchyma volumes were measured using FreeSurfer software. RESULTS: Data from 1,356 individuals were analyzed, and 25 (1.8%) individuals had DESH. Regarding the relationships between the volume of each CSF space and age, VS and SF volumes increased with age, whereas SHM volume did not increase. VS and SF volumes increased as the whole brain volume decreased, whereas SHM volume did not increase even if the whole brain volume decreased; that is, SHM did not expand even if brain atrophy progressed. Moreover, lower Mini-Mental State Examination scores were significantly associated with lower SHM volume and higher VS volume. These associations remained significant even when individuals with DESH were excluded. CONCLUSIONS: This study showed that the volume of high-convexity and medial subarachnoid spaces did not expand and tended to decrease with age; the human brain continuously progresses toward a "DESH-like" morphology with aging in community-dwelling older persons (i.e., DESH might be an "accelerated aging stage" rather than an "age-related disorder"). Our results indicated that brain atrophy may be associated with the development of "DESH-like" morphology. In addition, this morphological change, as well as brain atrophy, is an important condition associated with cognitive decline in older adults. Our findings highlight the importance of investigating the aging process of CSF dynamics in the human brain to preserve brain health in older people.
    Oct. 2022, Fluids and barriers of the CNS, 19(1) (1), 82 - 82, English, International magazine
    Scientific journal

  • Azusa Miura, Nobuo Kashiwagi, M. Sakai, Tomoko Hyodo, Hiroto Takahashi, Yumiko Miyauchi, Osamu Maenishi, Kazunari Ishii, Katsuyuki Nakanishi, Noriyuki Tomiyama
    Oct. 2022, Clinical Radiology, 77(12) (12), 935 - 942, English
    [Refereed]
    Scientific journal

  • SungWoon Im, Kohei Hanaoka, Takahiro Yamada, Kazunari Ishii
    Objective: We evaluated the relationship between regional accumulations of the tau positron emission tomography (PET) tracer THK5351 and cognitive dysfunction in the Alzheimer's disease (AD) continuum. Methods: The cases of 18 patients with AD or mild cognitive impairment (MCI) due to AD who underwent three-dimensional MRI, fluoro-2-deoxyglucose (FDG)-(PET), Pittsburgh compound B (PiB)-amyloid PET, and THK5351-tau PET were analyzed. Their mean age was 70.6 ± 11.3, their mean Mini-Mental State Examination (MMSE) score was 22.3 ± 6.8, and their mean Alzheimer Disease Assessment Scale-Cognitive Subtest (ADAS) score was 12.5 ± 7.3. To determine the correlation between each patient's four imaging results and their MMSE and ADAS scores, we performed a voxel-wise statistical analysis with statistical parametric mapping (SPM). Results: The SPM analysis showed that the bilateral parietotemporal FDG accumulations and MMSE scores were positively correlated, and the bilateral parietotemporal FDG accumulations were negatively correlated with ADAS scores. There were significant correlations between bilateral parietotemporal and left posterior cingulate/precuneus THK5351 accumulations and MMSE/ADAS scores. Conclusion: In the AD brain, THK5351 correlates with neuropsychological test scores as well as or more additional than FDG due to its affinity for both tau and monoamine oxidase-B (MAO-B), and measurements of THK5351 may thus be useful in estimating the progression of AD.
    Oct. 2022, Asia Oceania Journal of Nuclear Medicine and Biology, English, International magazine
    [Refereed]
    Scientific journal

  • Mitsutaka Nemoto, Atsuko Tanaka, Hayato Kaida, Yuichi Kimura, Takashi Nagaoka, Takahiro Yamada, Kohei Hanaoka, Kazuhiro Kitajima, Tatsuya Tsuchitani, Kazunari Ishii
    We propose a method to detect primary and metastatic lesions with Fluorine-18 fluorodeoxyglucose (FDG) accumulation in the lung field, neck, mediastinum, and bony regions on the FDG-PET/CT images. To search for systemic lesions, various anatomical structures must be considered. The proposed method is addressed by using an extraction process for anatomical regions and a uniform lesion detection approach. The uniform approach does not utilize processes that reflect any region-specific anatomical aspects but has a machine-learnable framework. Therefore, it can work as a lesion detection process for a specific anatomical region if it machine-learns the specific region data. In this study, three lesion detection processes for the whole-body bone region, lung field, or neck-mediastinum region are obtained. These detection processes include lesion candidate detection and false positive (FP) candidate elimination. The lesion candidate detection is based on a voxel anomaly detection with a one-class support vector machine. The FP candidate elimination is performed using an AdaBoost classifier ensemble. The image features used by the ensemble are selected sequentially during training and are optimal for candidate classification. Three-fold cross-validation was used to detect performance with the 54 diseased FDG-PET/CT images. The mean sensitivity for detecting primary and metastatic lesions at 3 FPs per case was 0.89 with a 0.10 standard deviation (SD) in the bone region, 0.80 with a 0.10 SD in the lung field, and 0.87 with a 0.10 SD in the neck region. The average areas under the ROC curve were 0.887 with a 0.125 SD for detecting bone metastases, 0.900 with a 0.063 SD for detecting pulmonary lesions, and 0.927 with a 0.035 SD for detecting the neck-mediastinum lesions. These detection performances indicate that the proposed method could be applied clinically. These results also show that the uniform approach has high versatility for providing various lesion detection processes.
    Sep. 2022, Physics in medicine and biology, 67(19) (19), English, International magazine
    Scientific journal

  • Erena Kobayashi, Shigenori Kanno, Nobuko Kawakami, Wataru Narita, Makoto Saito, Keiko Endo, Masaki Iwasaki, Tomohiro Kawaguchi, Shigeki Yamada, Kazunari Ishii, Hiroaki Kazui, Masakazu Miyajima, Masatsune Ishikawa, Etsuro Mori, Teiji Tominaga, Fumiaki Tanaka, Kyoko Suzuki
    Abstract A number of vascular risk factors (VRFs) have been reported to be associated with idiopathic normal-pressure hydrocephalus (iNPH), but it remains unclear whether these VRFs are related to patient outcomes after shunt surgery. Therefore, we investigated the risk factors for unfavourable outcomes after shunt surgery in iNPH patients using two samples from Tohoku University Hospital and from a multicentre prospective trial of lumboperitoneal (LP) shunt surgery for patients with iNPH (SINPHONI-2). We enrolled 158 iNPH patients. We compared the prevalence of VRFs and clinical measures between patients with favourable and unfavourable outcomes and identified predictors of unfavourable outcomes using multivariate logistic regression analyses. The presence of hypertension, longer disease duration, more severe urinary dysfunction, and a lower Evans’ index were predictors of unfavourable outcomes after shunt surgery. In addition, hypertension and longer disease duration were also predictors in patients with independent walking, and a lower Evans’ index was the only predictor in patients who needed assistance to walk or could not walk. Our findings indicate that hypertension is the only VRF related to unfavourable outcomes after shunt surgery in iNPH patients. Larger-scale studies are needed to elucidate the reason why hypertension can affect the irreversibility of symptoms after shunt placement.
    Springer Science and Business Media LLC, Aug. 2022, Scientific Reports, 12(1) (1), 13921 - 13921, English, International magazine
    Scientific journal

  • 急性膵炎後のWONに対する画像診断および経皮的ドレナージの役割
    上月 瞭平, 鶴崎 正勝, 浦瀬 篤史, 小寺 卓, 平山 歩, 石井 一成, 大本 俊介, 竹中 完, 工藤 正俊
    (公社)日本医学放射線学会, Aug. 2022, 日本医学放射線学会秋季臨床大会抄録集, 58回, S439 - S440, Japanese

  • 外眼筋転移のMRI所見 他の非甲状腺性外眼筋腫瘤との比較
    三浦 あづさ, 柏木 伸夫, 酒井 美緒, 中西 克之, 兵頭 朋子, 石井 一成, 高橋 洋人, 綿谷 朋大, 崎須賀 敬央, 松尾 千聡, 有澤 亜津子, 富山 憲幸
    (公社)日本医学放射線学会, Aug. 2022, 日本医学放射線学会秋季臨床大会抄録集, 58回, S402 - S402, Japanese

  • Mika Yamamuro, Yoshiyuki Asai, Naomi Hashimoto, Nao Yasuda, Hiroto Kimura, Takahiro Yamada, Mitsutaka Nemoto, Yuichi Kimura, Hisashi Handa, Hisashi Yoshida, Koji Abe, Masahiro Tada, Hitoshi Habe, Takashi Nagaoka, Seiun Nin, Kazunari Ishii, Yongbum Lee
    SPIE, Jul. 2022, 16th International Workshop on Breast Imaging (IWBI2022)
    International conference proceedings

  • Mika Yamamuro, Yoshiyuki Asai, Naomi Hashimoto, Nao Yasuda, Hiroto Kimura, Takahiro Yamada, Mitsutaka Nemoto, Yuichi Kimura, Hisashi Handa, Hisashi Yoshida, Koji Abe, Masahiro Tada, Hitoshi Habe, Takashi Nagaoka, Seiun Nin, Kazunari Ishii, Yohan Kondo
    Jun. 2022, Biomedical physics & engineering express, 8(4) (4), English, International magazine
    Scientific journal

  • Hayato Kaida, Takeshi Okuda, Kohei Hanaoka, Kazunari Ishii
    ABSTRACT: A 20-year-old man had left visual impairment and homonymous hemianopsia. MRI findings suggested enlargement of an optic glioma, because optic glioma was indicated by MRI 14 years earlier without a definite pathological diagnosis. 11C-methionine (MET) PET showed high uptake in the tumor in the parasellar region. Transnasal endoscopic biopsy was performed, and an inflammatory pseudotumor (IPT) was diagnosed based on histopathological findings. High MET uptake in a parasellar IPT has apparently not been previously reported. Clinicians should be aware of the possibility of high MET uptake in IPT, because this image could provide an interpretation pitfall.
    Jun. 2022, Clinical nuclear medicine, 47(11) (11), 965 - 967, English, International magazine
    Scientific journal

  • Comparison between the mu-maps of different PET tracers: 18F-FDG and 18F-flutemetamol, generated by the attenuation correction method without external radiation source
    Takahiro Yamada, Kohei Hanaoka, Yoshiyuki Yamakawa, Suzuka Minagawa, Atsushi Ohtani, Tetsuro Mizuta, Hayato Kaida, Kazunari Ishii
    Jun. 2022, JOURNAL OF NUCLEAR MEDICINE, 63, English

  • Daisuke Morimoto-Ishikawa, Tomoko Hyodo, Mamoru Takenaka, Yuko Matsukubo, Isao Numoto, Makoto Itoh, Masato Ohmi, Ken Kamata, Yu Ueda, Miyuki Wakana, Masatoshi Kudo, Shigeyoshi Saito, Kazunari Ishii
    PURPOSE: To compare image quality and the detectability of gallstones in patients with T1 hyperintense bile between single breath-hold three-dimensional (3D) magnetic resonance cholangiopancreatography (MRCP) with gradient and spin-echo (GRASE) and with compressed sensing (CS). METHODS: We retrospectively evaluated patients who underwent MRCP using GRASE and CS and had hyperintense bile on T1-weighted fat-suppressed images. The relative duct-to-periductal contrast ratios (RCs) of each bile duct segment were calculated. Pancreaticobiliary duct visibility, motion artifacts, background suppression, and overall image quality were scored on a 5-point scale. The Wilcoxon signed-rank test was used to analyze differences in qualitative and quantitative results. Diagnostic performance in detecting common bile duct (CBD) and gallbladder stones was assessed using receiver operating characteristic (ROC) curves. RESULTS: In total, 96 patients were included in the study. RCs of all bile duct segments in GRASE MRCP were significantly lower than those in CS MRCP (p < 0.001). All biliary duct visibility and overall image quality had significantly higher scores in GRASE MRCP than in CS MRCP (p < 0.001-0.003). Area under ROC curves of GRASE MRCP and CS MRCP were 1.00 and 0.88 for CBD stone (p = 0.14) and 0.93 and 0.82 for gallbladder stone (p = 0.08), respectively. CONCLUSIONS: GRASE MRCP provides better image quality than CS MRCP in patients with hyperintense bile on T1-weighted images. The detectability of biliary stones was also higher in GRASE MRCP than in CS MRCP, although not significantly.
    Mar. 2022, European journal of radiology, 150, 110279 - 110279, English, International magazine
    Scientific journal

  • Native T1マッピングによる潰瘍性大腸炎の疾患活動性評価の初期検討
    石川 大介, 兵頭 朋子, 米田 頼晃, 上田 優, 宮越 敬三, 齋藤 茂芳, 石井 一成
    (公社)日本放射線技術学会, Mar. 2022, 日本放射線技術学会総会学術大会予稿集, 78回, 213 - 214, Japanese

  • Tetsuro Mizuta, Tetsuya Kobayashi, Yoshiyuki Yamakawa, Kohei Hanaoka, Shota Watanabe, Daisuke Morimoto-Ishikawa, Takahiro Yamada, Hayato Kaida, Kazunari Ishii
    AIM: The aim of this study was to evaluate an image reconstruction algorithm, including a new maximum-likelihood attenuation correction factor (ML-ACF) for time of flight (TOF) brain positron emission tomography (PET). METHODS: The implemented algorithm combines an ML-ACF method that simultaneously estimates both the emission image and attenuation sinogram from TOF emission data, and a scaling method based on anatomical features. To evaluate the algorithm's quantitative accuracy, three-dimensional brain phantom images were acquired and soft-tissue attenuation coefficients and emission values were analyzed. RESULTS: The heterogeneous distributions of attenuation coefficients in soft tissue, skull, and nasal cavity were sufficiently visualized. The attenuation coefficient of soft tissue remained within 5% of theoretical value. Attenuation-corrected emission showed no lateral differences, and significant differences among soft tissue were within the error range. CONCLUSION: The ML-ACF-based attenuation correction implemented for TOF brain PET worked well and obtained practical levels of accuracy.
    Feb. 2022, Annals of nuclear medicine, 36(4) (4), 420 - 426, English, Domestic magazine
    Scientific journal

  • Takayuki Kondo, Norikazu Hara, Satoshi Koyama, Yuichiro Yada, Kayoko Tsukita, Ayako Nagahashi, Takeshi Ikeuchi, Kenji Ishii, Takashi Asada, Tetsuaki Arai, Ryo Yamada, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina Carter, Sara Dolen, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, James Brewer, Helen V, erswag, Adam Fleisher, Judith L. Heidebrink, Joanne L. Lord, Sara S. Mason, Colleen S. Albers, David Knopman, Kris Johnson, Rachelle S. Doody, Javier Villanueva-Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Beau Ances, John C. Morris, Maria Carroll, Mary L. Creech, Erin Franklin, Mark A. Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, R, all Griffith, David Clark, David Geldmacher, John Brockington, Erik Roberson, Marissa Natelson Love, Hillel Grossman, Effie Mitsis, Raj C. Shah, Leyla deToledo-Morrell, Ranjan Duara, Daniel Varon, Maria T. Greig, Peggy Roberts, Marilyn Albert, Chiadi Onyike, Daniel D'Agostino, Stephanie Kielb, James E. Galvin, Brittany Cerbone, Christina A. Michel, Dana M. Pogorelec, Henry Rusinek, Mony J. de Leon, Lidia Glodzik, Susan De Santi, P. Murali Doraiswamy, Jeffrey R. Petrella, Salvador Borges-Neto, Terence Z. Wong, Edward Coleman, Charles D. Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Anton P. Porsteinsson, Bonnie S. Goldstein, Kim Martin, Kelly M. Makino, M. Saleem Ismail, Connie Br, Ruth A. Mulnard, Gaby Thai, Catherine Mc-Adams-Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel H. S. Silverman, Po H. Lu, George Bartzokis, Neill R. Graff-Radford, Francine Parfitt, Tracy Kendall, Heather Johnson, Martin R. Farlow, Ann Marie Hake, Br, y R. Matthews, Jared R. Brosch, Scott Herring, Cynthia Hunt, Christopher H. van Dyck, Richard E. Carson, Martha G. MacAvoy, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, S, ra Black, Bojana Stefanovic, Curtis Caldwell, Ging-Yuek Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly, Elizabeth Finger, Stephen Pasternack, Irina Rachisky, Dick Trost, Andrew Kertesz, Charles Bernick, Donna Munic, Marek Marsel Mesulam, Kristine Lipowski, S, ra Weintraub, Borna Bonakdarpour, Diana Kerwin, Chuang-Kuo Wu, Nancy Johnson, Carl Sadowsky, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A. Sperling, Keith A. Johnson, Gad Marshall, Jerome Yesavage, Joy L. Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N. Sabbagh, Christine M. Belden, S, ra A. Jacobson, Sherye A. Sirrel, Neil Kowall, Ronald Killiany, Andrew E. Budson, Alex, er Norbash, Patricia Lynn Johnson, Thomas O. Obisesan, Saba Wolday, Joanne Allard, Alan Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, Evan Fletcher, Pauline Maillard, John Olichney, Charles DeCarli, Owen Carmichael, Smita Kittur, Michael Borrie, T.-Y. Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia M. Carlsson, Steven G. Potkin, Adrian Preda, Dana Nguyen, Pierre Tariot, Anna Burke, Nadira Trncic, Adam Fleisher, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W. Scharre, Maria Kataki, Anahita Adeli, Earl A. Zimmerman, Dzintra Celmins, Alice D. Brown, Godfrey D. Pearlson, Karen Blank, Karen Anderson, Laura A. Flashman, Marc Seltzer, Mary L. Hynes, Robert B. Santulli, Kaycee M. Sink, Leslie Gordineer, Jeff D. Williamson, Pradeep Garg, Franklin Watkins, Brian R. Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J. Rosen, Bruce L. Miller, David Perry, Jacobo Mintzer, Kenneth Spicer, David Bachman, Nunzio Pomara, Raymundo Hern, o, Antero Sarrael, Norman Relkin, Gloria Chaing, Michael Lin, Lisa Ravdin, Am, a Smith, Balebail Ashok Raj, Kristin Fargher, Takeshi Iwatsubo, Takashi Asada, Hiroyuki Arai, Morihiro Sugishita, Hiroshi Matsuda, Kengo Ito, Michio Senda, Kenji Ishii, Ryozo Kuwano, Takeshi Ikeuchi, Noriko Sato, Hajime Sato, Shun Shimohama, Masaki Saitoh, Rika Yamauchi, Takashi Hayashi, Seiju Kobayashi, Norihito Nakano, Junichiro Kanazawa, Takeshi Ando, Chiyoko Takanami, Masato Hareyama, Masamitsu Hatakenaka, Eriko Tsukamoto, Shinji Ochi, Mikio Shoji, Etsuro Matsubara, Takeshi Kawarabayashi, Yasuhito Wakasaya, Takashi Nakata, Naoko Nakahata, Shuichi Ono, Yoshihiro Takai, Satoshi Takahashi, Hisashi Yonezawa, Junko Takahashi, Masako Kudoh, Makoto Sasaki, Yutaka Matsumura, Yohsuke Hirata, Tsuyoshi Metoki, Susumu Hayakawa, Yuichi Sato, Masayuki Takeda, Toshiaki Sasaki, Koichiro Sera, Kazunori Terasaki, Yoshihiro Saitoh, Shoko Goto, Kuniko Ueno, Hiromi Sakashita, Kuniko Watanabe, Ken Nagata, Yuichi Sato, Tetsuya Maeda, Yasushi Kondoh, Takashi Yamazaki, Daiki Takano, Mio Miyata, Hiromi Komatsu, Mayumi Watanabe, Tomomi Sinoda, Rena Muraoka, Kayoko Kikuchi, Hitomi Ito, Aki Sato, Toshibumi Kinoshita, Hideyo Toyoshima, Kaoru Sato, Shigeki Sugawara, Isao Ito, Fumiko Kumagai, Hiroyuki Arai, Katsutoshi Furukawa, Masaaki Waragai, Naoki Tomita, Nobuyuki Okamura, Mari Ootsuki, Katsumi Sugawara, Satomi Sugawara, Shunji Mugikura, Atsushi Umetsu, Takanori Murata, Tatsuo Nagasaka, Yukitsuka Kudo, Manabu Tashiro, Shoichi Watanuki, Masatoyo Nishizawa, Takeshi Ikeuchi, Takayoshi Tokutake, Saeri Ishikawa, Emiko Kishida, Nozomi Sato, Mieko Hagiwara, Kumi Yamanaka, Takeyuki Watanabe, Taeko Takasugi, Shoichi Inagawa, Kenichi Naito, Masanori Awaji, Tsutomu Kanazawa, Kouiti Okamoto, Masaki Ikeda, Tsuneo Yamazaki, Yuiti Tasiro, Syunn Nagamine, Shiori Katsuyama, Sathiko Kurose, Sayuri Fukushima, Etsuko Koya, Makoto Amanuma, Noboru Oriuti, Kouiti Ujita, Kazuhiro Kishi, Kazuhisa Tuda, Takashi Asada, Katsuyoshi Mizukami, Tetsuaki Arai, Etsuko Nakajima, Katsumi Miyamoto, Kousaku Saotome, Tomoya Kobayashi, Saori Itoya, Jun Ookubo, Toshiya Akatsu, Yoshiko Anzai, Junya Ikegaki, Yuuichi Katou, Kaori Kimura, Ryou Kuchii, Hajime Saitou, Kazuya Shinoda, Satoka Someya, Hiroko Taguchi, Kazuya Tashiro, Masaya Tanaka, Tatsuya Nemoto, Ryou Wakabayashi, Daisuke Watanabe, Harumasa Takano, Tetsuya Suhara, Hitoshi Shinoto, Hitoshi Shimada, Makoto Higuchi, Takaaki Mori, Hiroshi Ito, Takayuki Obata, Yoshiko Fukushima, Kazuko Suzuki, Izumi Izumida, Katsuyuki Tanimoto, Takahiro Shiraishi, Hitoshi Shinotoh, Hitoshi Shimada, Junko Shiba, Hiroaki Yano, Miki Satake, Aimi Nakui, Yae Ebihara, Tomomi Hasegawa, Yasumasa Yoshiyama, Mami Kato, Yuki Ogata, Hiroyuki Fujikawa, Nobuo Araki, Yoshihiko Nakazato, Takahiro Sasaki, Tomokazu Shimadu, Kimiko Yoshimaru, Hiroshi Matsuda, Etsuko Imabayashi, Asako Yasuda, Etuko Yamamoto, Natsumi Nakamata, Noriko Miyauchi, Keiko Ozawa, Rieko Hashimoto, Taishi Unezawa, Takafumi Ichikawa, Hiroki Hayashi, Masakazu Yamagishi, Tunemichi Mihara, Masaya Hirano, Shinichi Watanabe, Junichiro Fukuhara, Hajime Matsudo, Nobuyuki Saito, Atsushi Iwata, Hisatomo Kowa, Toshihiro Hayashi, Ryoko Ihara, Toji Miyagawa, Mizuho Yoshida, Yuri Koide, Eriko Samura, Kurumi Fujii, Kaori Watanabe, Nagae Orihara, Toshimitsu Momose, Akira Kunimatsu, Harushi Mori, Miwako Takahashi, Takuya Arai, Yoshiki Kojima, Masami Goto, Takeo Sarashina, Syuichi Uzuki, Seiji Katou, Yoshiharu Sekine, Yukihiro Takauchi, Chiine Kagami, Kazutomi Kanemaru, Shigeo Murayama, Yasushi Nishina, Kenji Ishii, Maria Sakaibara, Yumiko Okazaki, Rieko Okada, Maki Obata, Yuko Iwata, Mizuho Minami, Yasuko Hanabusa, Hanae Shingyouji, Kyoko Tottori, Aya Tokumaru, Makoto Ichinose, Kazuya Kume, Syunsuke Kahashi, Kunimasa Arima, Tadashi Tukamoto, Shin Tanaka, Yuko Nagahusa, Masuhiro Sakata, Mitsutoshi Okazaki, Yuko Saito, Maki Yamada, Tiine Kodama, Maki Obata, Tomoko Takeuchi, Keiichiro Ozawa, Yuko Iwata, Hanae Shingyouji, Yasuko Hanabusa, Yoshiko Kawaji, Kyouko Tottori, Noriko Sato, Yasuhiro Nakata, Satoshi Sawada, Makoto Mimatsu, Daisuke Nakkamura, Takeshi Tamaru, Shunichirou Horiuchi, Heii Arai, Tsuneyoshi Ota, Aiko Kodaka, Yuko Tagata, Tomoko Nakada, Eizo Iseki, Kiyoshi Sato, Hiroshige Fujishiro, Norio Murayama, Masaru Suzuki, Satoshi Kimura, Masanobu Takahashi, Haruo Hanyu, Hirofumi Sakurai, Takahiko Umahara, Hidekazu Kanetaka, Kaori Arashino, Mikako Murakami, Ai Kito, Seiko Miyagi, Kaori Doi, Kazuyoshi Sasaki, Mineo Yamazaki, Akiko Ishiwata, Yasushi Arai, Akane Nogami, Sumiko Fukuda, Kyouko Tottori, Mizuho Minami, Yuko Iwata, Koichi Kozaki, Yukiko Yamada, Sayaka Kimura, Ayako Machida, Kuninori Kobayashi, Hidehiro Mizusawa, Nobuo Sanjo, Mutsufusa Watanabe, Takuya Ohkubo, Hiromi Utashiro, Yukiko Matsumoto, Kumiko Hagiya, Yoshiko Miyama, Takako Shinozaki, Haruko Hiraki, Hitoshi Shibuya, Isamu Ohashi, Akira Toriihara, Shinichi Ohtani, Toshifumi Matsui, Yu Hayasaka, Tomomi Toyama, Hideki Sakurai, Kumiko Sugiura, Hirofumi Taguchi, Shizuo Hatashita, Akari Imuta, Akiko Matsudo, Daichi Wakebe, Hideki Hayakawa, Mitsuhiro Ono, Takayoshi Ohara, Yukihiko Washimi, Yutaka Arahata, Akinori Takeda, Yoko Konagaya, Akiko Yamaoka, Masashi Tsujimoto, Hideyuki Hattori, Takashi Sakurai, Miura Hisayuki, Hidetoshi Endou, Syousuke Satake, Young Jae Hong, Katsunari Iwai, Kenji Yoshiyama, Masaki Suenaga, Sumiko Morita, Teruhiko Kachi, Kenji Toba, Rina Miura, Takiko Kawai, Ai Honda, Kengo Itou, Takashi Kato, Ken Fujiwara, Rikio Katou, Mariko Koyama, Naohiko Fukaya, Akira Tsuji, Hitomi Shimizu, Hiroyuki Fujisawa, Tomoko Nakazawa, Satoshi Koyama, Takanori Sakata, Masahito Yamada, Mitsuhiro Yoshita, Miharu Samuraki, Kenjiro Ono, Moeko Shinohara, Yuki Soshi, Kozue Niwa, Chiaki Doumoto, Mariko Hata, Miyuki Matsushita, Mai Tsukiyama, Nozomi Takeda, Sachiko Yonezawa, Ichiro Matsunari, Osamu Matsui, Fumiaki Ueda, Yasuji Ryu, Masanobu Sakamoto, Yasuomi Ouchi, Yasuomi Ouchi, Madoka Chita, Yumiko Fujita, Rika Majima, Hiromi Tsubota, Umeo Shirasawa, Masashi Sugimori, Wataru Ariya, Yuuzou Hagiwara, Yasuo Tanizaki, Hidenao Fukuyama, Ryosuke Takahashi, Hajime Takechi, Chihiro Namiki, Kengo Uemura, Takeshi Kihara, Hiroshi Yamauchi, Shizuko Tanaka-Urayama, Emiko Maeda, Natsu Saito, Shiho Satomi, Konomi Kabata, Shin-Ichi Urayama, Tomohisa Okada, Koichi Ishizu, Shigeto Kawase, Satoshi Fukumoto, Masanori Nakagawa, Takahiko Tokuda, Masaki Kondo, Fumitoshi Niwa, Toshiki Mizuno, Yoko Oishi, Mariko Yamazaki, Daisuke Yamaguchi, Kyoko Ito, Yoku Asano, Chizuru Hamaguchi, Kei Yamada, Chio Okuyama, Kentaro Akazawa, Shigenori Matsushima, Takamasa Matsuo, Toshiaki Nakagawa, Takeshi Nii, Takuji Nishida, Kuniaki Kiuchi, Masami Fukusumi, Hideyuki Watanabe, Toshiaki Taoka, Akihiro Nogi, Masatoshi Takeda, Toshihisa Tanaka, Naoyuki Sato, Hiroaki Kazui, Kenji Yoshiyama, Takashi Kudo, Masayasu Okochi, Takashi Morihara, Shinji Tagami, Noriyuki Hayashi, Masahiko Takaya, Tamiki Wada, Mikiko Yokokoji, Hiromichi Sugiyama, Daisuke Yamamoto, Shuko Takeda, Keiko Nomura, Mutsumi Tomioka, Eiichi Uchida, Yoshiyuki Ikeda, Mineto Murakami, Takami Miki, Hiroyuki Shimada, Suzuka Ataka, Motokatsu Kanemoto, Jun Takeuchi, Akitoshi Takeda, Rie Azuma, Yuki Iwamoto, Naomi Tagawa, Junko Masao, Yuka Matsumoto, Yuko Kikukawa, Hisako Fujii, Junko Matsumura, Susumu Shiomi, Joji Kawabe, Yoshihiro Shimonishi, Yukio Miki, Mitsuji Higashida, Tomohiro Sahara, Takashi Yamanaga, Shinichi Sakamoto, Hiroyuki Tsushima, Kiyoshi Maeda, Yasuji Yamamoto, Toshio Kawamata, Kazuo Sakai, Haruhiko Oda, Takashi Sakurai, Taichi Akisaki, Mizuho Adachi, Masako Kuranaga, Sachi Takegawa, Yoshihiko Tahara, Seishi Terada, Takeshi Ishihara, Hajime Honda, Osamu Yokota, Yuki Kishimoto, Naoya Takeda, Nao Imai, Mayumi Yabe, Kentaro Ida, Daigo Anami, Seiji Inoue, Toshi Matsushita, Reiko Wada, Shinsuke Hiramatsu, Hiromi Tonbara, Reiko Yamamoto, Kenji Nakashima, Kenji Wada-Isoe, Saori Yamasaki, Eijiro Yamashita, Yu Nakamura, Ichiro Ishikawa, Sonoko Danjo, Tomomi Shinohara, Miyuki Ueno, Yuka Kashimoto, Yoshihiro Nishiyama, Yuka Yamamoto, Narihide Kimura, Kazuo Ogawa, Yasuhiro Sasakawa, Takashi Ishimori, Yukito Maeda, Tatsuo Yamada, Shinji Ouma, Aika Fukuhara-Kaneumi, Nami Sakamoto, Rie Nagao, Kengo Yoshimitsu, Yasuo Kuwabara, Ryuji Nakamuta, Minoru Tanaka, Manabu Ikeda, Mamoru Hashimoto, Keiichirou Kaneda, Yuusuke Yatabe, Kazuki Honda, Naoko Ichimi, Fumi Akatuka, Mariko Morinaga, Miyako Noda, Mika Kitajima, Toshinori Hirai, Shinya Shiraishi, Naoji Amano, Shinsuke Washizuka, Toru Takahashi, Shin Inuzuka, Tetsuya Hagiwara, Nobuhiro Sugiyama, Yatsuka Okada, Tomomi Ogihara, Takehiko Yasaki, Minori Kitayama, Tomonori Owa, Akiko Ryokawa, Rie Takeuchi, Satoe Goto, Keiko Yamauchi, Mie Ito, Tomoki Kaneko, Hitoshi Ueda, Shuichi Ikeda, Masaki Takao, Ban Mihara, Hirofumi Kubo, Akiko Takano, Gou Yasui, Masami Akuzawa, Kaori Yamaguchi, Toshinari Odawara, Megumi Shimamura, Mikiko Sugiyama, Atsushi Watanabe, Naomi Oota, Shigeo Takebayashi, Yoshigazu Hayakawa, Mitsuhiro Idegawa, Noriko Toya, Kazunari Ishii, Haruhisa Inoue
    Springer Science and Business Media {LLC}, Feb. 2022, Nature Aging, 2(2) (2), 125 - 139, English
    Scientific journal

  • Takashi Nakata, Kenichi Shimada, Akiko Iba, Haruhiko Oda, Akira Terashima, Yutaka Koide, Ryota Kawasaki, Takahiro Yamada, Kazunari Ishii
    OBJECTIVE: This study aimed at investigating the correlation between recurrent visual hallucinations (VHs) and regional cerebral blood flow (rCBF) in patients with dementia with Lewy bodies (DLB). METHODS: In 147 DLB patients, the correlation between noise pareidolia scores and rCBF in brain perfusion single photon emission computed tomography (SPECT) was evaluated. The 147 subjects comprised 52 probable and 95 possible DLB patients, of whom 107 did not have visual hallucinations and 40 had visual hallucinations. Brain perfusion SPECT was then performed, and memory impairment was assessed using the Mini-Mental State Examination (MMSE), while the optical illusion "pareidolia" (the tendency to see a specific image in a random visual pattern) was evaluated using noise pareidolia test. The correlations between rCBF and MMSE or noise pareidolia scores were then analyzed. RESULTS: The rCBF and MMSE scores were positively correlated, and rCBF was correlated with MMSE scores in a region that was consistent with a previously reported memory-related site. There was no correlation between noise pareidolia scores and occipital CBF, but there were weak correlations between noise pareidolia scores and rCBF in the bilateral frontal lobes (Brodmann area [BA]8 and BA9), left cingulate cortex (BA31), and left angular and supramarginal gyri (BA39 and BA40) in DLB patients. CONCLUSION: Weak correlation was found between noise pareidolia scores and rCBF in several sites (BA8, BA9, BA31, BA39 and BA40) other than in occipital lobe. These findings suggest that DLB hallucinations may be manifested by more complex brain network disorders, rather than by primary visual cortex disorders alone.
    Jan. 2022, Annals of nuclear medicine, 36(4) (4), 384 - 392, English, Domestic magazine
    Scientific journal

  • Takashi Kato, Yukiko Nishita, Rei Otsuka, Yoshitaka Inui, Akinori Nakamura, Yasuyuki Kimura, Kengo Ito
    This study aimed to investigate the effect of cognitive reserve (CR) on the rate of cognitive decline and cerebral glucose metabolism in amnestic mild cognitive impairment (MCI) using the Study on Diagnosis of Early Alzheimer's Disease-Japan (SEAD-J) dataset. The patients in SEAD-J underwent cognitive tests and fluorodeoxyglucose-positron emission tomography (FDG-PET). MCI to be studied was classified as amnestic MCI due to Alzheimer's disease (AD) with neurodegeneration. A total of 57 patients were visually interpreted as having an AD pattern (P1 pattern, Silverman's classification). The 57 individuals showing the P1 pattern were divided into a high-education group (years of school education ≥13, N = 18) and a low-education group (years of school education ≤12, N = 39). Voxel-based statistical parametric mapping revealed more severe hypometabolism in the high-education group than in the low-education group. Glucose metabolism in the hippocampus and temporoparietal area was inversely associated with the years of school education in the high- and low-education groups (N = 57). General linear mixed model analyses demonstrated that cognitive decline was more rapid in the high-education group during 3-year follow-up. These results suggest that the cerebral glucose metabolism is lower and cognitive function declines faster in patients with high CR of amnestic MCI due to AD defined by FDG-PET.
    2022, Frontiers in aging neuroscience, 14, 932906 - 932906, English, International magazine
    Scientific journal

  • Kensaku Kasuga, Masataka Kikuchi, Tamao Tsukie, Kazushi Suzuki, Ryoko Ihara, Atsushi Iwata, Norikazu Hara, Akinori Miyashita, Ryozo Kuwano, Takeshi Iwatsubo, Takeshi Ikeuchi
    Background: The AT(N) classification was proposed for categorising individuals according to biomarkers. However, AT(N) profiles may vary depending on the markers chosen and the target population. Methods: We stratified 177 individuals who participated in the Japanese Alzheimer's Disease Neuroimaging Initiative by AT(N) classification according to cerebrospinal fluid (CSF) biomarkers. We compared the frequency of AT(N) profiles between the classification using total tau and neurofilament light chain (NfL) as N markers (AT(N)tau and AT(N)NfL). Baseline characteristics, and longitudinal biological and clinical changes were examined between AT(N) profiles. Results: We found that 9% of cognitively unimpaired subjects, 49% of subjects with mild cognitive impairment, and 61% of patients with Alzheimer's disease (AD) dementia had the biological AD profile (ie, A+T+) in the cohort. The frequency of AT(N) profiles substantially differed between the AT(N)tau and AT(N)NfL classifications. When we used t-tau as the N marker (AT(N)tau), those who had T- were more frequently assigned to (N)-, whereas those who had T+were more frequently assigned to (N)+ than when we used NfL as the N marker (AT(N)NfL). During a follow-up, the AD continuum group progressed clinically and biologically compared with the normal biomarker group in both the AT(N)tau and AT(N)NfL classifications. More frequent conversion to dementia was observed in the non-AD pathological change group in the AT(N)tau classification, but not in the AT(N)NfL classification. Conclusions: AT(N)tau and AT(N)NfL in CSF may capture different aspects of neurodegeneration and provide a different prognostic value. The AT(N) classification aids in understanding the AD continuum biology in various populations.
    2022, BMJ neurology open, 4(2) (2), e000321, English, International magazine
    Scientific journal

  • Takashi Nagaoka, Takenori Kozuka, Takahiro Yamada, Hitoshi Habe, Mitsutaka Nemoto, Masahiro Tada, Koji Abe, Hisashi Handa, Hisashi Yoshida, Kazunari Ishii, Yuichi Kimura
    Japanese Society for Medical and Biological Engineering, 2022, Advanced Biomedical Engineering, 11, 76 - 86
    Scientific journal

  • Nobuo Kashiwagi, Koichi Miyazaki, Hiroto Takahashi, Kiyoshi Tsuji, Masahiro Fujiwara, Atsuko Arisawa, Hajime Nakamura, Haruhiko Kishima, Kazunari Ishii, Noriyuki Tomiyama
    BACKGROUND AND PURPOSE: To report 9 new cases of non-cavernous sinus dural arteriovenous fistulas (NCS-DAVFs) that closed spontaneously and systematically review reports of other cases in the literature. MATERIAL AND METHODS: We performed a retrospective analysis of 9 cases from 2 institutions of NCS-DAVFs that closed spontaneously. Using PubMed and Scopus in accordance with the PRISMA guidelines, we systematically reviewed English language articles about NCS-DAVFs showing spontaneous closure. RESULTS: Review of the cases from 2 institutions identified 9 cases of NCS-DAVFs showing spontaneous closure in follow-up magnetic resonance angiography (MRA), and the systematic review of the literature yielded an additional 38 cases, which had been diagnosed by repeated arteriography. Collectively, the patients included 23 men and 24 women with a mean age of 54 years. The shunts were located in the transverse-sigmoid sinus in 24 cases (51%), anterior condylar confluence in 11, and other locations in 12. Based on the venous drainage pattern on arteriography, 27 cases (57%) were classified as low-risk NCS-DAVF (without cortical venous reflux) and 17 were classified as high-risk NCS-DAVF (with cortical venous reflux). Shunt closure was observed within 3 months in 17 cases (36%). Extrinsic predisposing factors for shunt closure were detected in 14 cases (30%). These included angiography in 7 cases, sinus recanalization in 4, development of sinus occlusion in 2, and sinus compression by a newly developed hematoma in 1. CONCLUSION: Spontaneous closures of NCS-DAVFs can occur for both high- and low-risk types. One-third of these closures occur within 3 months.
    Jan. 2022, Journal of neuroradiology = Journal de neuroradiologie, 49(1) (1), 94 - 100, English, International magazine
    Scientific journal

  • Paulus Kapundja Shigwedha, Takahiro Yamada, Kohei Hanaoka, Kazunari Ishii, Yuichi Kimura, Yutaka Fukuoka
    Positron emission tomography (PET) is a physiological, non-invasive imaging technique, which forms an essential part of nuclear medicine. The data obtained in a PET scan represent the concentration of an administered radiotracer in tissues over time. Quantitative analysis of PET data makes possible the assessments of in-vivo physiological processes. The Logan graphical analysis (LGA) is one of the methods that are used for quantitative analysis of PET data. LGA transforms PET data into a simple linear relationship. The slope of the LGA linear relationship is a physiological quantity denoting receptor availability. This quantity is termed distribution volume ratio (DVR). LGA-based estimates of the DVR are negatively affected by the noise in PET data -leading to the DVR being underestimated. A number of approaches proposed to address this issue have been observed to reduce the bias at the cost precision. An alternative regression method, least-squares cubic (LSC), was recently applied to estimate the DVR in order to reduce the bias. LSC was observed to reduce the bias in the LGA-based estimates. However, slight increases were also observed in the variance of the LSC-based estimates. This calls for methods to act against the variance in the LSC-based estimates. In this study, an alternative method is applied for tTAC denoising. This method is referred to as correlated component analysis (CorrCA). CorrCA transform the data by searching for dimensions of maximum correlation. This technique is closely related to other well-known methods such as principal component analysis and independent component analysis. In this study, the data were denoised by CorrCA (to act against the variance in the estimate) and the DVR was estimated by LSC, which provides for minimal bias. The resulting method LSC-CorrCA, gave less-biased estimated with increased precision. This was observed for both simulation results as well as for clinical data, both for 11C Pittsburgh compound B. Simulation data revealed reduced variances in LCS-CorrCA-based estimates, and the clinical data showed improved contrast between gray and white matter regions.Clinical Relevance-Improved DVR estimates would ease the interpretation of medical images, which will in turn positively influence the clinical processes, from diagnosis to treatment and follow-ups.
    Nov. 2021, Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2021, 3680 - 3683, English, International magazine
    Scientific journal

  • Takahisa Sakisuka, Nobuo Kashiwagi, Hiroshi Doi, Hiroto Takahashi, Atsuko Arisawa, Chisato Matsuo, Yu Masuda, Hidenori Inohara, Kazuaki Sato, Hidetatsu Outani, Kazunari Ishii, Noriyuki Tomiyama
    Although bone is the second-most frequent site of distant metastases of head and neck squamous cell carcinoma (HNSCC), variable prognostic factors in patients with bone metastases from HNSCC have not been fully investigated. The aim of the present study was to assess the prognostic factors affecting overall survival (OS) in these patients. The medical records of 97 patients at two institutions who developed bone metastases from HNSCC between January 2010 and December 2020 were retrospectively reviewed. A multivariate analysis using a Cox proportional hazards model was performed to identify potential clinical predictive factors for longer OS. The median OS was 7 months, and the 1- and 2-year OS rates for all patients were 35.4 and 19.2%, respectively. The independent predictive factors for longer OS were single bone metastasis, good performance status and administration of systemic chemotherapy. The median OS with each predictor was 10, 10 and 10.5 months, respectively. In a selected group of patients with these three factors, the OS was 14.5 months. In conclusion, single bone metastasis, a good performance status and systemic chemotherapy were independent predictors of longer OS in patients with HNSCC, but their contributions were limited.
    Nov. 2021, Molecular and clinical oncology, 15(5) (5), 246 - 246, English, International magazine
    Scientific journal

  • Shota Watanabe, Kenta Sakaguchi, Daisuke Murata, Kazunari Ishii
    Oct. 2021, Computers in biology and medicine, 137, 104824 - 104824, English, International magazine
    Scientific journal

  • Shota Watanabe, Kenta Sakaguchi, Daisuke Murata, Kazunari Ishii
    BACKGROUND: Patient movement during bolus tracking (BT) impairs the accuracy of Hounsfield unit (HU) measurements. This study assesses the accuracy of measuring HU values in the internal carotid artery (ICA) using an original deep learning (DL)-based method as compared with using the conventional region of interest (ROI) setting method. METHOD: A total of 722 BT images of 127 patients who underwent cerebral computed tomography angiography were selected retrospectively and divided into groups for training data, validation data, and test data. To segment the ICA using our proposed method, DL was performed using a convolutional neural network. The HU values in the ICA were obtained using our DL-based method and the ROI setting method. The ROI setting was performed with and without correcting for patient body movement (corrected ROI and settled ROI). We compared the proposed DL-based method with settled ROI to evaluate HU value differences from the corrected ROI, based on whether or not patients experienced involuntary movement during BT image acquisition. RESULTS: Differences in HU values from the corrected ROI in the settled ROI and the proposed method were 23.8 ± 12.7 HU and 9.0 ± 6.4 HU in patients with body movement and 1.1 ± 1.6 HU and 3.9 ± 4.7 HU in patients without body movement, respectively. There were significant differences in both comparisons (P < 0.01). CONCLUSION: DL-based method can improve the accuracy of HU value measurements for ICA in BT images with patient involuntary movement.
    Sep. 2021, Computers in biology and medicine, 137, 104824 - 104824, English, International magazine
    Scientific journal

  • Kiyoto Takigawa, Masahiko Takaya, Kazunari Ishii, Kazumasa Saigoh, Osamu Shirakawa
    A patient with Alzheimer's disease (AD) pathology when cognitive impairment is detected tends to be diagnosed with AD. However, before diagnosing, we make an effort to exclude other diseases, for example, carcinoma.
    Jul. 2021, Clinical case reports, 9(7) (7), e04482, English, International magazine

  • Masahiko Takaya, Kazunari Ishii, Kazumasa Saigoh, Osamu Shirakawa
    BACKGROUND: Alzheimer's disease is a neurodegenerative disease involving the deposition of pathologic amyloid-β and tau protein in the cerebral cortex. Alzheimer's disease is commonly characterized by progressive impairment of recent memory. Primary progressive aphasia is also often observed in patients with Alzheimer's disease. Moreover, language-associated symptoms, such as primary progressive aphasia, are diverse and varied in Alzheimer's disease. However, nonfluent/agrammatic variant primary progressive aphasia is not generally considered a symptom of Alzheimer's disease. To date, there has been no longitudinal study of primary progressive aphasia in Japanese-speaking patients or in patients speaking other languages with pathologically diagnosed Alzheimer's disease. Here we present a longitudinal study of primary progressive aphasia in a Japanese patient pathologically diagnosed with Alzheimer's disease. CASE PRESENTATION: A 75-year-old Japanese man, whose wife reported that his memory was impaired, also suffered from suspected aphasia. He was pathologically diagnosed with Alzheimer's disease using 11C-Pittsburgh compound-B positron emission tomography and 18F-THK5351 positron emission tomography. Based on clinical observation and the results of the Japanese standard language test of aphasia, he was also diagnosed with nonfluent/agrammatic variant primary progressive aphasia. During the subsequent 2 years, his cognitive impairment, aphasia, and behavioral and psychological symptoms of dementia progressed. Furthermore, progression of pathologic amyloid-β and tau protein deposition was revealed through 11C-Pittsburgh compound-B positron emission tomography and 18F-THK5351 positron emission tomography. Although the results of [123I] iodoamphetamine single-photon emission computed tomography suggested corticobasal degeneration, this was not observed on the [123I] FP-CIT single-photon emission computed tomography (SPECT) (DaTscan). A previous study had reported that Alzheimer's disease with a nonfluent/agrammatic variant primary progressive aphasia was accompanied by corticobasal degeneration; however, this was not true in our case. CONCLUSIONS: This is possibly the first longitudinal study of nonfluent/agrammatic variant primary progressive aphasia in a Japanese-speaking patient with pathologically diagnosed Alzheimer's disease, but without corticobasal degeneration.
    May 2021, Journal of medical case reports, 15(1) (1), 272 - 272, English, International magazine
    Scientific journal

  • Tanyaluck Thientunyakit, Thonnapong Thongpraparn, Chakmeedaj Sethanandha, Takahiro Yamada, Yuichi Kimura, Weerasak Muangpaisan, Kazunari Ishii
    PURPOSE: To determine the association between occipital amyloid-PET uptake and neurocognitive performance in Alzheimer's disease (AD). MATERIALS AND METHODS: Fifty-eight participants with normal aged, mild cognitive impairment (MCI) due to AD and AD subjects who underwent F-18 florbetapir brain PET/CT scans were divided into four groups (A, normal; B, MCI; C, mild AD; and D, moderate/severe AD). Semiquantitative analyses of SUVR images were performed. The differences between groups and the correlations between florbetapir uptake and Thai Mental State Examination (TMSE) scores were determined. Significant differences were defined using a P < 0.001, uncorrected, or a P < 0.05, FWE for the voxel-based analyses with Statistical Parametric Mapping (SPM). RESULTS: There was a slightly higher florbetapir uptake in the precuneus, parietal, and occipital association cortices in Group B > A. The occipital florbetapir uptake in Groups C and D was significantly higher than in Group A, in addition to the precuneus, anterior cingulate, posterior cingulate, temporoparietal, and frontal cortices. There was a strong negative correlation between TMSE scores and florbetapir uptake in the occipital lobe. CONCLUSIONS: Occipital amyloid uptake is associated with clinically advanced AD, and is inversely correlated with neurocognitive performance and may be useful for evaluating AD severity.
    May 2021, Japanese journal of radiology, 39(10) (10), 984 - 993, English, Domestic magazine
    Scientific journal

  • Hayato Kaida, Kazuhiro Kitajima, Masatoyo Nakajo, Mana Ishibashi, Tomoyuki Matsunaga, Ryogo Minamimoto, Kenji Hirata, Koya Nakatani, Ao Hung, Satoshi Hattori, Takushi Yasuda, Kazunari Ishii
    PURPOSE: To investigate the usefulness of the positron emission tomography response criteria in solid tumors 1.0 (PERCIST1.0) for predicting tumor response to neoadjuvant chemotherapy and prognosis and determine whether PERCIST improvements are necessary for esophageal squamous cell carcinoma (ESCC) patients. PATIENTS AND METHODS: We analyzed the cases of 177 ESCC patients and examined the association between PERCIST and their pathological responses. Associations of whole-PERCIST with progression-free survival (PFS) and overall survival (OS) were evaluated by a Kaplan-Meier analysis and Cox proportional hazards model. To investigate potential PERCIST improvements, we used the survival tree technique to understand patients' prognoses. RESULTS: There were significant correlations between the pathologic response and PERCIST of primary tumor (p < 0.001). The optimal cutoff value of the primary tumors' SULpeak response to classify pathologic responses was -50.0%. The diagnostic accuracy of SULpeak response was 87.3% sensitivity, 54.1% specificity, 68.9% accuracy, positive predictive value 60.5%, and negative predictive value 84.1%. Whole-PERCIST was significantly associated with PFS and OS. The survival tree results indicated that a high reduction of the whole SULpeak response was significantly correlated with the patients' prognoses. The cutoff values for the separation of prognoses were - 52.5 for PFS and - 47.1% for OS. CONCLUSION: PERCIST1.0 can help predict tumor responses and prognoses. However, 18F-FDG-PET/CT tends to underestimate residual tumors in histopathological response evaluations. Modified PERCIST, in which the partial metabolic response is further classified by the SULpeak response (-50%), might be more appropriate than PERCIST1.0 for evaluating tumor responses and stratifying high-risk patients for recurrence and poor prognosis.
    May 2021, European journal of nuclear medicine and molecular imaging, 48(11) (11), 3666 - 3682, English, International magazine
    Scientific journal

  • Mitsuru Matsuki, Isao Numoto, Takefumi Hamakawa, Kazunari Ishii, Takaaki Chikugo
    Diaphragmatic endometriosis is extremely rare. Although endometriosis is considered generally benign, malignant transformation of endometriosis was reported in 1925. Multiple studies have since described clear cell carcinoma (CCC) or endometrioid carcinoma arising from ovarian endometriosis. Previously, only two reports of primary diaphragmatic CCC were reported, in which coexistent endometriosis with CCC was not histologically proven. We report a case of a 55-year-old postmenopausal woman who was admitted to Kindai university hospital for the examination of a cystic mass with papillary components in the right diaphragm. On her past medical history, abdominal hysterectomy and bilateral salpingo-oophorectomy was performed for high-grade cervical intraepithelial neoplasia, uterine myoma, and bilateral ovarian endometriosis 5 years ago. Unenhanced CT performed 5 years ago, showed a nodular lesion with low density in the right diaphragm, consistent with diaphragmatic endometriosis. Magnetic resonance imaging during this admission, showed a cystic mass with papillary components in the right diaphragm and a T2*-weighted gradient echo imaging showed partial low signal intensity in the papillary components and cyst wall, which was suspected to represent hemosiderin deposition. Based on these serial images, malignant transformation of diaphragmatic endometriosis was suspected. Under, open abdominal combined resection of the mass and part of the diaphragm was performed. Endometriosis implants were detected on the pelvic peritoneum. Histopathological examination revealed clear cell carcinoma associated with endometriosis and hemosiderin deposition in the cyst wall. T2*-weighted gradient echo imaging was useful in the detection of hemosiderin deposition caused by the coexistent endometriosis. When a cystic mass with papillary components and cyst wall with hemosiderin deposits are encountered on MR images, malignant transformation of endometriosis is suspected and a detailed medical history should be determined and the possibility of concurrent endometriosis or adenomyosis should be investigated, as should the potential existence of diaphragmatic endometriosis in previous images.
    May 2021, Gynecologic oncology reports, 36, 100733 - 100733, English, International magazine

  • Kenta Sakaguchi, Hayato Kaida, Shuhei Yoshida, Kazunari Ishii
    OBJECTIVE: Non-uniform attenuation correction using computed tomography (CT) improves the image quality and quantification of single-photon emission computed tomography (SPECT). However, it is not widely used because it requires a SPECT/CT scanner. This study constructs a convolutional neural network (CNN) to generate attenuation-corrected SPECT images directly from non-attenuation-corrected SPECT images. METHODS: We constructed an auto-encoder (AE) using a CNN to correct the attenuation in brain perfusion SPECT images. SPECT image datasets of 270 (44,528 slices including augmentation), 60 (5002 slices), and 30 (2558 slices) cases were used for training, validation, and testing, respectively. The acquired projection data were reconstructed in three patterns: uniform attenuation correction using Chang's method (Chang-AC), non-uniform attenuation correction using CT (CT-AC), and no attenuation correction (No-AC). The AE learned an end-to-end mapping between the No-AC and CT-AC images. The No-AC images in the test dataset were loaded into the trained AE, which generated images simulating the CT-AC images as output. The generated SPECT images were employed as attenuation-corrected images using the AE (AE-AC). The accuracy of the AE-AC images was evaluated in terms of the peak signal-to-noise ratio (PSNR) and the structural similarity metric (SSIM). The intensities of the AE-AC and CT-AC images were compared by voxel-by-voxel and region-by-region analysis. RESULTS: The PSNRs of the AE-AC and Chang-AC images, compared using CT-AC images, were 62.2, and 57.9, and their SSIM values were 0.9995 and 0.9985, respectively. The AE-AC and CT-AC images were visually and statistically in good agreement. CONCLUSIONS: The proposed AE-AC method yields highly accurate attenuation-corrected brain perfusion SPECT images.
    May 2021, Annals of nuclear medicine, 35(5) (5), 589 - 599, English, Domestic magazine
    Scientific journal

  • Ryuichi Takahashi, Kazunari Ishii, Kaoru Sousa, Kohei Marumoto, Tetsuo Kashibayashi, Jun Fujita, Kazumasa Yokoyama
    PURPOSE: This study aimed to identify regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative parkinsonisms, using dopamine transporter single-photon emission computed tomography images. MATERIAL AND METHODS: This study included 213 consecutive participants (Parkinson's disease [n = 111], dementia with Lewy bodies [n = 64], progressive supranuclear palsy with Richardson's syndrome [n = 18], and healthy participants [n = 20]) who underwent both magnetic resonance imaging and 123I-labelled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single-photon emission computed tomography/computed tomography. Using normalized specific binding ratio images, we created voxel-wise regional asymmetry index images to identify the regional specific pattern of regional asymmetries in degenerative parkinsonisms. RESULTS: Compared with healthy controls, patients with Parkinson's disease showed a regional asymmetry index increase in the nigrostriatal dopaminergic pathway, and those with dementia with Lewy bodies showed a regional asymmetry index increase confined to the bilateral caudate. Individuals with progressive supranuclear palsy exhibited a distinct regional asymmetry index increase in the pallido-subthalamic pathway. Notably, the regional asymmetry index increase in the subthalamic nucleus was significantly greater in progressive supranuclear palsy than in Parkinson's disease. CONCLUSION: The current study revealed distinctive regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative parkinsonisms. The present findings highlight the potential application of visual diagnosis in degenerative parkinsonisms.
    Apr. 2021, Journal of the neurological sciences, 423, 117363 - 117363, English, International magazine
    Scientific journal

  • Masakatsu Tsurusaki, Keitaro Sofue, Hiromitsu Onishi, Satoshi Goshima, Atsushi Higaki, Hiroyoshi Isoda, Hiroki Haradome, Kazunari Ishii, Takamichi Murakami
    Apr. 2021, Japanese journal of radiology, 39(4) (4), 405 - 405, English, Domestic magazine

  • Isao Numoto, Masakatsu Tsurusaki, Teruyoshi Oda, Yukinobu Yagyu, Kazunari Ishii, Takamichi Murakami
    The authors are sorry to report that the overall survival reported in their recently published paper was incorrect [...].
    Mar. 2021, Cancers, 13(6) (6), English, International magazine

  • Paulus Kapundja Shigwedha, Takahiro Yamada, Kohei Hanaoka, Kazunari Ishii, Yuichi Kimura, Yutaka Fukuoka
    Logan graphical analysis (LGA) is a method for in vivo quantification of tracer kinetics in positron emission tomography (PET). The shortcoming of LGA is the presence of a negative bias in the estimated parameters for noisy data. Various approaches have been proposed to address this issue. We recently applied an alternative regression method called least-squares cubic (LSC), which considers the errors in both the predictor and response variables to estimate the LGA slope. LSC reduced the bias in non-displaceable binding potential estimates while causing slight increases in the variance. In this study, we combined LSC with a principal component analysis (PCA) denoising technique to counteract the effects of variance on parametric image quality, which was assessed in terms of the contrast between gray and white matter. Tissue time-activity curves were denoised through PCA, prior to estimating the regression parameters using LSC. We refer to this approach as LSC-PCA. LSC-PCA was assessed against OLS-PCA (PCA with ordinary least-squares (OLS)), LSC, and conventional OLS-based LGA. Comparisons were made for simulated11C-carfentanil and11C Pittsburgh compound B (11C-PiB) data, and clinical11C-PiB PET images. PCA-based methods were compared over a range of principal components, varied by the percentage variance they account for in the data. The results showed reduced variances in distribution volume ratio estimates in the simulations for LSC-PCA compared to LSC, and lower bias compared to OLS-PCA and OLS. Contrasts were not significantly improved in clinical data, but they showed a significant improvement in simulation data |indicating a potential advantage of LSC-PCA over OLS-PCA. The effects of bias reintroduction when many principal components are used were also observed in OLS-PCA clinical images. We therefore encourage the use of LSC-PCA. LSC-PCA can allow the use of many principal components with minimal risk of bias, thereby strengthening the interpretation of PET parametric images.
    Mar. 2021, Biomedical physics & engineering express, English, International magazine
    Scientific journal

  • Mika Yamamuro, Yoshiyuki Asai, Naomi Hashimoto, Nao Yasuda, Takahiro Yamada, Mitsutaka Nemoto, Yuichi Kimura, Hisashi Handa, Hisashi Yoshida, Koji Abe, Masahiro Tada, Hitoshi Habe, Takashi Nagaoka, Yoshiaki Ozaki, Seiun Nin, Kazunari Ishii, Yongbum Lee
    Feb. 2021, Medical Imaging 2021: Computer-Aided Diagnosis, 11597, English
    International conference proceedings

  • Madoka Nakajima, Shigeki Yamada, Masakazu Miyajima, Kazunari Ishii, Nagato Kuriyama, Hiroaki Kazui, Hideki Kanemoto, Takashi Suehiro, Kenji Yoshiyama, Masahiro Kameda, Yoshinaga Kajimoto, Mitsuhito Mase, Hisayuki Murai, Daisuke Kita, Teruo Kimura, Naoyuki Samejima, Takahiko Tokuda, Mitsunobu Kaijima, Chihiro Akiba, Kaito Kawamura, Masamichi Atsuchi, Yoshihumi Hirata, Mitsunori Matsumae, Makoto Sasaki, Fumio Yamashita, Shigeki Aoki, Ryusuke Irie, Hiroji Miyake, Takeo Kato, Etsuro Mori, Masatsune Ishikawa, Isao Date, Hajime Arai
    Among the various disorders that manifest with gait disturbance, cognitive impairment, and urinary incontinence in the elderly population, idiopathic normal pressure hydrocephalus (iNPH) is becoming of great importance. The first edition of these guidelines for management of iNPH was published in 2004, and the second edition in 2012, to provide a series of timely, evidence-based recommendations related to iNPH. Since the last edition, clinical awareness of iNPH has risen dramatically, and clinical and basic research efforts on iNPH have increased significantly. This third edition of the guidelines was made to share these ideas with the international community and to promote international research on iNPH. The revision of the guidelines was undertaken by a multidisciplinary expert working group of the Japanese Society of Normal Pressure Hydrocephalus in conjunction with the Japanese Ministry of Health, Labour and Welfare research project. This revision proposes a new classification for NPH. The category of iNPH is clearly distinguished from NPH with congenital/developmental and acquired etiologies. Additionally, the essential role of disproportionately enlarged subarachnoid-space hydrocephalus (DESH) in the imaging diagnosis and decision for further management of iNPH is discussed in this edition. We created an algorithm for diagnosis and decision for shunt management. Diagnosis by biomarkers that distinguish prognosis has been also initiated. Therefore, diagnosis and treatment of iNPH have entered a new phase. We hope that this third edition of the guidelines will help patients, their families, and healthcare professionals involved in treating iNPH.
    Feb. 2021, Neurologia medico-chirurgica, 61(2) (2), 63 - 97, English, Domestic magazine
    Scientific journal

  • Masakatsu Tsurusaki, Keitaro Sofue, Hiromitsu Onishi, Satoshi Goshima, Atsushi Higaki, Hiroyoshi Isoda, Hiroki Haradome, Kazunari Ishii, Takamichi Murakami
    PURPOSE: To identify predictive factors for truncation artifacts (TAs) in the arterial phase of Gd-EOB-DTPA-enhanced MRI in a multicenter study in Japan. MATERIALS AND METHODS: Data on patient factors (age, sex, weight, presence of viral hepatitis, and other conditions) and imaging parameters (e.g., triggering, voxel size, matrix, k-space ordering, acquisition time, reduction factor, flip angle, fat suppression, field strength, injection rate, and saline volume) were obtained. Univariate and multivariate analyses were performed to investigate the correlation of these parameters. RESULTS: We evaluated 1444 patients from 43 institutions who were scanned using GE, Siemens, Philips, or Toshiba MRI equipment (501, 354, 349, and 240 patients, respectively). The total incidence of TAs was 12.5% (17.2, 3.6, 15.7, and 12.1%, respectively). The matrix [odds ratio (OR) 0.13], flip angle (OR 5.77), use of fat suppression (OR 0.106), and field strength (OR 0.092) used in the Philips equipment significantly increased the incidence of TAs in MRI examination. CONCLUSIONS: The incidence of TAs in the arterial phase is influenced by several patient factors and imaging parameters. Especially, Siemens and Toshiba equipment had a significantly lower frequency of TAs. This indicates that such vendor-specific technology used in the dynamic sequence may have a TA-resistant effect.
    Feb. 2021, Japanese journal of radiology, 39(2) (2), 165 - 177, English, Domestic magazine
    Scientific journal

  • Masakatsu Tsurusaki, Keitaro Sofue, Masatoshi Hori, Kosuke Sasaki, Kazunari Ishii, Takamichi Murakami, Masatoshi Kudo
    Dual-energy computed tomography (DECT) is an imaging technique based on data acquisition at two different energy settings. Recent advances in CT have allowed data acquisitions and simultaneous analyses of X-rays at two energy levels, and have resulted in novel developments in the field of abdominal imaging. The use of low and high X-ray tube voltages in DECT provide fused images that improve the detection of liver tumors owing to the higher contrast-to-noise ratio (CNR) of the tumor compared with the liver. The use of contrast agents in CT scanning improves image quality by enhancing the CNR and signal-to-noise ratio while reducing beam-hardening artifacts. DECT can improve detection and characterization of hepatic abnormalities, including mass lesions. The technique can also be used for the diagnosis of steatosis and iron overload. This article reviews and illustrates the different applications of DECT in liver imaging.
    Jan. 2021, Diagnostics (Basel, Switzerland), 11(2) (2), English, International magazine
    Scientific journal

  • Kazuhiro Kitajima, Yasuo Miyoshi, Tetsuro Sekine, Hiroyuki Takei, Kimiteru Ito, Akihiko Suto, Hayato Kaida, Kazunari Ishii, Hiromitsu Daisaki, Koichiro Yamakado
    OBJECTIVES: This study investigated harmonized pretreatment volume-based quantitative FDG-PET/CT parameters in breast cancer patients for prognostic value. RESULTS: During a median overall follow-up period of 5.3 years, 91 patients had recurrence and 40 died. Multivariate analysis of ER-positive/HER2-negative patients showed high maximum standardized uptake value (SUVmax) (p = 0.018), high total lesion glycolysis (TLG) (p = 0.010), and clinical N-classification (p = 0.0027) as independent negative predictors of RFS, while high maximum SUVmax (p = 0.037), advanced clinical T-classification (p = 0.030), and advanced TNM stage (p = 0.0067) were independent negative predictors of OS. For recurrence and death in HER2-positive patients, high total TLG (p = 0.037, p = 0.0048, respectively) and advanced TNM stage (p = 0.048, p = 0.046, respectively) were independent prediction factors. In the triple-negative group, independent factors related to recurrence and death were high maximum SUVmax (p = 0.0014, p = 0.0003, respectively) and advanced TNM stage (p < 0.0001, p < 0.0001, respectively). MATERIALS AND METHODS: Records of 546 stage I-III invasive breast cancer patients, including 344 estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative, 110 HER2-positive, and 92 triple-negative cases, treated at four institutions were reviewed retrospectively. Harmonized primary tumor and nodal maximum SUVmax, metabolic tumor volume (MTV), and TLG indicated in pretreatment FDG-PET/CT results were analyzed. Evaluations of relationships of clinicopathological factors, volume-based quantitative parameters, recurrence-free survival (RFS), and overall survival (OS) for each subtype were performed with a Cox proportional hazards model and log-rank test. CONCLUSIONS: The results indicated that potential surrogate markers for prognosis in patients with the three main subtypes of operable breast cancer include harmonized pretreatment quantitative volume-based FDG-PET/CT parameters, particularly whole-lesion SUVmax and TLG.
    Jan. 2021, Oncotarget, 12(2) (2), 95 - 105, English, International magazine
    Scientific journal

  • Shota Watanabe, Kohei Hanaoka, Hayato Kaida, Tomoko Hyodo, Minoru Yamada, Masakatsu Tsurusaki, Kazunari Ishii
    Objectives: To assess respiratory-gated (RG) positron emission tomography (PET) acquisition for patients with liver metastases during delayed PET/computed tomography (CT) scanning with fluorine-18-fluorodeoxyglucose (18F-FDG). Methods: Nineteen patients with liver metastases who had undergone early whole-body 18F-FDG PET/CT scans without the RG technique and delayed scans with the RG technique were retrospectively selected. The maximum standardized uptake value (SUVmax) of 41 liver lesions and the tumor-to-liver uptake ratios (TLRs) for these same lesions were compared among three data sets: early non-respiratory-gated (early non-RG) images, delayed non-respiratory-gated (delayed non-RG) images, and delayed respiratory-gated (delayed RG) images. In the delayed non-RG and delayed RG images, the improvements in the TLR, relative to the early non-RG images, were assessed according to lesion size. Results: For liver lesions, the SUVmax of early non-RG, delayed non-RG, and delayed RG images were 6.58±2.34, 7.69±3.08, and 9.47±3.73, respectively. There were significant differences among the three images (P<0.01). The TLR of the delayed RG images was significantly higher than those of the early non-RG and delayed non-RG images (P<0.01). In the delayed RG images, the difference in the TLR improvement for lesions ≤10 mm in size was 15% higher than that for lesions >10 mm in size; in the delayed non-RG images, the difference in the TLR improvement for the same lesion categories was 6%. Conclusion: Delayed RG imaging improves the TLR, compared with early non-RG and delayed non-RG imaging, especially for small lesions. RG PET acquisition may be a promising protocol for assessing liver metastases on delayed PET/CT scans.
    2021, Asia Oceania journal of nuclear medicine & biology, 9(2) (2), 12 - 149, English, International magazine
    Scientific journal

  • Mika Yamamuro, Yoshiyuki Asai, Naomi Hashimoto, Nao Yasuda, Yoshiaki Ozaki, Kazunari Ishii, Yongbum Lee
    2021, PloS one, 16(1) (1), e0245060, English, International magazine
    Scientific journal

  • Kazunari Ishii, Takahiro Yamada, Kohei Hanaoka, Hayato Kaida, Koichi Miyazaki, Masami Ueda, Kazushi Hanada, Kazumasa Saigoh, Julia Sauerbeck, Axel Rominger, Peter Bartenstein, Yuichi Kimura
    PURPOSE: It is usually easy to judge whether amyloid PET images should be interpreted as positive or negative for amyloid deposits by visual inspection or quantitative measurement standard uptake value ratio (SUVR), but the findings are equivocal in some cases. As conventional mean cortical SUVR (mcSUVR) measures accumulation in both gray matter (GM) and white matter, it may mis-estimate amyloid deposits. The purpose of the study was to develop a regional GM-dedicated SUVR measuring (GMSUVR) system for amyloid PET images with 3D-MRI, and evaluate its utility for detecting amyloid deposits in equivocal cases. METHODS: Of 126 subjects who underwent amyloid PET with 11C-PiB and 3D-MRI, the area of amyloid-positive regions and the critical regional GMSUVR thresholds were first determined in 15 amyloid-positive and 15 amyloid-negative patients, using the automatic volumetric measurement of segmented brain images system. We then tested 36 amyloid-negative, 60 amyloid-positive, and 13 equivocal subjects with this GMSUVR system and with conventional mcSUVR. RESULTS: Sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were 100%, 92%, 97%, 95%, and 100% for the GMSUVR system; and 97%, 86%, 93%, 92% and 94%, respectively, for mcSUVR. In 24 cases in which the findings were equivocal or discordant, the sensitivity, specificity, accuracy, PPV, and NPV were all 100% for the GMSUVR system; and were 90%, 33%, 83%, 90%, and 33%, respectively, for mcSUVR. CONCLUSION: The regional GMSUVR measurement method was well able to discriminate between amyloid-positive and -negative subjects, even in cases where amyloid deposition was equivocal.
    Springer Science and Business Media {LLC}, Nov. 2020, Annals of nuclear medicine, 34(11) (11), 856 - 863, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Takenori Kozuka, Yuko Matsukubo, Tomoya Kadoba, Teruyoshi Oda, Ayako Suzuki, Tomoko Hyodo, SungWoon Im, Hayato Kaida, Yukinobu Yagyu, Masakatsu Tsurusaki, Mitsuru Matsuki, Kazunari Ishii
    PURPOSE: To evaluate the performance of a deep learning-based computer-aided diagnosis (CAD) system at detecting pulmonary nodules on CT by comparing radiologists' readings with and without CAD. MATERIALS AND METHODS: A total of 120 chest CT images were randomly selected from patients with suspected lung cancer. The gold standard of nodules ≥ 3 mm was established by a panel of three expert radiologists. Two less experienced radiologists read the images without and afterward with CAD system. Their reading times were recorded. RESULTS: The radiologists' sensitivity increased from 20.9% to 38.0% with the introduction of CAD. The positive predictive value (PPV) decreased from 70.5% to 61.8%, and the F1-score increased from 32.2% to 47.0%. The sensitivity significantly increased from 13.7% to 32.4% for small nodules (3-6 mm) and from 33.3% to 47.6% for medium nodules (6-10 mm). CAD alone showed a sensitivity of 70.3%, a PPV of 57.9%, and an F1-score of 63.5%. Reading time decreased by 11.3% with the use of CAD. CONCLUSION: CAD improved the less experienced radiologists' sensitivity in detecting pulmonary nodules of all sizes, especially including a significant improvement in the detection of clinically important-sized medium nodules (6-10 mm) as well as small nodules (3-6 mm) and reduced their reading time.
    Springer Science and Business Media LLC, Nov. 2020, Japanese journal of radiology, 38(11) (11), 1052 - 1061, English, Domestic magazine
    [Refereed]
    Scientific journal

  • 食道癌の術前化学療法に対するFDG-PET/CTの有用性 多施設共同研究
    甲斐田 勇人, 北島 一宏, 中條 正豊, 石橋 愛, 南本 亮吾, 平田 健司, 中谷 航也, Ao Hung, 服部 聡, 安田 卓司, 石井 一成
    (一社)日本核医学会, Oct. 2020, 核医学, 57(Suppl.) (Suppl.), S144 - S144, Japanese

  • アルツハイマー病疑い患者の18F-flutemetamol PETの定量評価
    松田 博史, 伊藤 健吾, 石井 一成, 下瀬川 恵久, 岡沢 秀彦, 三品 雅洋, 水村 直, 石井 賢二, 沖田 恭治, 重本 蓉子, 山尾 天翔
    (一社)日本核医学会, Oct. 2020, 核医学, 57(Suppl.) (Suppl.), S142 - S142, Japanese

  • アルツハイマー病疑い患者の18F-flutemetamol PETの定量評価
    松田 博史, 伊藤 健吾, 石井 一成, 下瀬川 恵久, 岡沢 秀彦, 三品 雅洋, 水村 直, 石井 賢二, 沖田 恭治, 重本 蓉子, 山尾 天翔
    (一社)日本核医学会, Oct. 2020, 核医学, 57(Suppl.) (Suppl.), S142 - S142, Japanese

  • Mana Okune, Masakazu Yasuda, Naoko Soejima, Yoshinori Kagioka, Kazuyoshi Kakehi, Takayuki Kawamura, Kohei Hanaoka, Hayato Kaida, Kazunari Ishii, Gaku Nakazawa, Shunichi Miyazaki, Yoshitaka Iwanaga
    BACKGROUND: Although each 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and cardiac magnetic resonance (CMR) imaging with late gadolinium enhancement (LGE) has been used to diagnose cardiac sarcoidosis (CS), active CS is still misdiagnosed. METHODS: Active CS, diagnosed by PET alone, was defined as focal or focal on diffuse FDG uptake pattern. In fusion PET/CMR imaging, using a regional analysis with AHA 17-segment model, the patients were categorized into four groups: (1) PET-/LGE-, (2) PET+/LGE-, (3) PET+/LGE+, and (4) PET-/LGE+. PET+/LGE+ was defined as active CS. RESULTS: 74 Patients with suspected CS were enrolled. Between PET alone and fusion PET/CMR imaging, 20 cases had mismatch evaluations of active CS, and most had diffuse or focal on diffuse FDG uptake pattern on PET alone imaging. 40 Patients fulfilled the 2016 the Japanese Circulation Society diagnostic criteria for CS. The interobserver diagnostic agreement was excellent (κ statistics 0.89) and the overall accuracy for diagnosing CS was 87.8% in fusion PET/CMR imaging, which were superior to those in PET alone imaging (0.57 and 82.4%, respectively). In a sub-analysis of diffuse and focal on diffuse patterns, the agreement (κ statistics 0.86) and overall accuracy (81.8%) in fusion PET/CMR imaging were still better. CONCLUSIONS: Fusion PET/CMR imaging with regional analysis offered reliable and accurate diagnosis of CS, covering low diagnostic area by FDG-PET alone.
    Oct. 2020, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 29(2) (2), 753 - 764, English, International magazine
    Scientific journal

  • Daisuke Morimoto, Tomoko Hyodo, Ken Kamata, Tomoya Kadoba, Makoto Itoh, Hiroyuki Fukushima, Yasutaka Chiba, Mamoru Takenaka, Tomohiro Mochizuki, Yu Ueda, Keizou Miyagoshi, Masatoshi Kudo, Kazunari Ishii
    PURPOSE: To examine whether MRCP using a combination of compressed sensing and sensitivity encoding with navigator-triggered and breath-hold techniques (NT C-SENSE and BH C-SENSE, respectively) have comparable image quality to that of navigator-triggered MRCP using only sensitivity encoding (NT SENSE) at 1.5-T. METHODS: Fifty-one participants were enrolled in this prospective study between July and October 2018 and underwent the three 3D MRCP sequences each. The acquisition time and relative duct-to-periductal contrast ratios (RC values) of each bile duct segment were obtained. Visualization of the bile and main pancreatic ducts, background suppression, artifacts, and overall image quality were scored on 5-point scales. Mean and median differences in RC values and qualitative scores of NT C-SENSE and BH C-SENSE relative to NT SENSE were calculated with 95% confidence intervals (CIs). RESULTS: Acquisition time of NT SENSE, NT C-SENSE, and BH C-SENSE were 348, 143 (mean for both), and 18 s (for all participants), respectively. The RC value of each bile duct segment was inferior, but the lower limits of the 95% CIs of the mean differences were ≥ - 0.10, for both NT C-SENSE and BH C-SENSE. The visualization score of the intrahepatic duct in BH C-SENSE was inferior to that in NT SENSE (lower 95% CI limit, - 1.5). In both NT C-SENSE and BH C-SENSE, the 95% CIs of the median differences in the other qualitative scores were from - 1.0 to 0.0. CONCLUSION: NT C-SENSE and BH C-SENSE have comparable image quality to NT SENSE at 1.5-T.
    Oct. 2020, Abdominal radiology (New York), 45(10) (10), 3081 - 3091, English, International magazine
    [Refereed]
    Scientific journal

  • Mitsuru Matsuki, Isao Numoto, Ayako Suzuki, Takefumi Hamakawa, Yuko Matsukubo, Masakatsu Tsurusaki, Kazunari Ishii, Tomoyuki Otani, Noriomi Matsumura
    OBJECTIVE: The aim of the study was to characterize magnetic resonance imaging findings in patients with recurrent ovarian adult granulosa cell tumors (AGCTs). METHODS: Clinical and magnetic resonance imaging manifestations of recurrent AGCTs were evaluated in 11 patients. RESULTS: Initial recurrences of AGCT were diagnosed between 13 months and 30 years (mean, 11.3 years). Recurrent tumors were located in the pelvic peritoneum, the abdominal peritoneum, the retroperitoneum, and bone. The number of recurrent tumors varied from 1 to 5. Tumors varied in morphology and all margins were well circumscribed. The internal structures noted were as follows: multilocular cystic and solid and cystic. Furthermore, internal hemorrhage and sponge-like multicystic components were identified. CONCLUSIONS: Ovarian AGCTs recurred in the pelvic peritoneum, abdominal peritoneum, and the retroperitoneal lymph nodes. Large recurrent AGCTs were commonly well circumscribed, round or lobulated, and multilocular cystic or solid and cystic. Moreover, they frequently included internal hemorrhage and sponge-like multicystic components.
    Sep. 2020, Journal of computer assisted tomography, English, International magazine
    Scientific journal

  • Isao Numoto, Masakatsu Tsurusaki, Teruyoshi Oda, Yukinobu Yagyu, Kazunari Ishii, Takamichi Murakami
    PURPOSE: To evaluate the efficacy and safety of transcatheter arterial embolization (TAE) for pseudoaneurysms occurring secondary to pancreatitis or because of leakage of pancreatic juice after pancreatectomy. MATERIALS AND METHODS: This retrospective study included 42 consecutive patients (38 males and 4 females; mean age, 60 years; range, 33-80 years) who underwent TAE for bleeding visceral artery pseudoaneurysms between March 2004 and December 2018. The technical and clinical success rates, incidence of recurrent bleeding, complications, including pancreatitis, and overall survival after TAE were evaluated. RESULTS: Of the 42 enrolled patients, 23 had bleeding due to a complication of pancreatectomy and 19 had bleeding as a complication of pancreatitis. TAE with N-butyl cyanoacrylate (NBCA) or NBCA plus microcoils recurrent bleeding or inability to control bleeding was 15.8% (3 of 19) following TAE with NBCA and 17.4% (4 of 23) following TAE with coils. No clinically significant ischemic events of the pancreas or duodenum were observed in the embolized areas. Serum amylase did not increase compared with the initial levels after any of the procedures. At 30 days after TAE, 32 patients were alive. CONCLUSION: TAE has a high success rate for the management of hemorrhage, with few complications. The procedure appears to be safe and effective for pseudoaneurysms associated with either pancreatitis or pancreatectomy.
    {MDPI} {AG}, Sep. 2020, Cancers, 12(10) (10), 2733 - 2733, English, International magazine
    [Refereed]
    Scientific journal

  • Masahiko Takaya, Kazunari Ishii, Kaori Kiguchi, Kazumasa Saigoh, Osamu Shirakawa
    BACKGROUND: Developmental disorder and dementia in older adults have been considered unrelated clinical entities because their timing of diagnosis differs greatly; however, recent studies have suggested an association between them. This case describes a middle-aged patient with language disorder exhibiting progressive amnestic cognitive impairment. CASE PRESENTATION: A 44-year-old Japanese man with long-term language dysfunction presented for his first-ever medical evaluation at age 36 years. Although his conversational ability had been impaired since childhood, he was able to graduate from secondary school and gain unskilled employment. At age 36 years, however, his workplace environment became more stressful, which led to behavioral problems that necessitated medical consultation. He consulted two psychiatrists in vain. At age 44 years, the third attending psychiatrist examined him in detail. The major component of his language disorder was amnestic cognitive impairment in the language domain as shown by logical memory subtests of the Wechsler Memory Scale-Revised. Magnetic resonance imaging showed normal findings for his age and no small vessel disease. Global cerebral hypoperfusion versus cerebellar blood flow was shown on (123I) iodoamphetamine single-photon emission computed tomography, and amyloid-β deposition was negative on positron emission tomography with 11C-Pittsburgh compound B. Pathologic tau accumulation was negative on 18F-THK5351 positron emission tomography imaging. Laboratory tests show no infections, no vitamin deficiencies, and no other diseases that may cause dementia. Clinical features, results of neurocognitive tests and neuroimaging studies showed no well-known neurodegenerative diseases. Collectively, he was diagnosed with language disorder based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria. Over a 2-year follow-up period, amnestic cognitive impairment in visual and language domains progressed in parallel with global cerebral hypoperfusion. CONCLUSION: This case suggests a possible link between language disorder as defined by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria and progressive amnestic cognitive impairment in middle age, which may ultimately lead to dementia, derived from a neurodegenerative disease.
    Sep. 2020, Journal of medical case reports, 14(1) (1), 139 - 139, English, International magazine
    [Refereed]
    Scientific journal

  • One-class SVMによる画素悪性度の集中性を用いたFDG-PET/CT上の病変自動検出
    田中 敦子, 根本 充貴, 甲斐田 勇人, 木村 裕一, 永岡 隆, 牛房 和之, 山田 誉大, 花岡 宏平, 北島 一宏, 槌谷 達也, 石井 一成
    日本医用画像工学会, Sep. 2020, 日本医用画像工学会大会予稿集, 39回, 29 - 29, Japanese

  • One-class SVMによる画素悪性度の集中性を用いたFDG-PET/CT上の病変自動検出
    田中 敦子, 根本 充貴, 甲斐田 勇人, 木村 裕一, 永岡 隆, 牛房 和之, 山田 誉大, 花岡 宏平, 北島 一宏, 槌谷 達也, 石井 一成
    日本医用画像工学会, Sep. 2020, 日本医用画像工学会大会予稿集, 39回, 153 - 158, Japanese

  • 小塚 健倫, 石井 一成, 清水 重喜
    (株)学研メディカル秀潤社, Sep. 2020, 画像診断, 40(11) (11), A168 - A184, Japanese

  • WONのCT所見とステップアップアプローチ
    沼本 勲男, 鶴崎 正勝, 小田 晃義, 柳生 行伸, 石井 一成, 大本 俊介, 竹中 完, 工藤 正敏
    (一社)日本インターベンショナルラジオロジー学会, Aug. 2020, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 205 - 205, Japanese

  • Shota Watanabe, Katsuhiro Ichikawa, Hiroki Kawashima, Yuki Kono, Hiroyuki Kosaka, Koji Yamada, Kazunari Ishii
    Aug. 2020, PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 76, 100 - 108, English, International magazine
    [Refereed]
    Scientific journal

  • Yuichi Kimura, Aya Watanabe, Takahiro Yamada, Shogo Watanabe, Takashi Nagaoka, Mitsutaka Nemoto, Koichi Miyazaki, Kohei Hanaoka, Hayato Kaida, Kazunari Ishii
    OBJECTIVE: An artificial intelligence (AI)-based algorithm typically requires a considerable amount of training data; however, few training images are available for dementia with Lewy bodies and frontotemporal lobar degeneration. Therefore, this study aims to present the potential of cycle-consistent generative adversarial networks (CycleGAN) to obtain enough number of training images for AI-based computer-aided diagnosis (CAD) algorithms for diagnosing dementia. METHODS: We trained CycleGAN using 43 amyloid-negative and 45 positive images in slice-by-slice. RESULTS: The CycleGAN can be used to synthesize reasonable amyloid-positive images, and the continuity of slices was preserved. DISCUSSION: Our results show that CycleGAN has the potential to generate a sufficient number of training images for CAD of dementia.
    Jul. 2020, Annals of nuclear medicine, 34(7) (7), 512 - 515, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Masakatsu Tsurusaki, Isao Numoto, Teruyoshi Oda, Miyuki Wakana, Ayako Suzuki, Yukinobu Yagyu, Mitsuru Matsuki, Kazunari Ishii
    The aim of this study was to investigate the impact of radiologic experience on the diagnostic accuracy of computed tomography (CT) vs. magnetic resonance imaging (MRI) reporting on the liver metastases of pancreatic ductal adenocarcinoma (LM of PDAC). Intra-individual CT and MRI examinations of 112 patients with clinically proven LM of PDAC were included. Four radiologists with varying years of experience (A > 20, B > 5, C > 1 and D < 1) assessed liver segments affected by LM of PDAC, as well as associated metastases occurring in each patient. Their sensitivity and specificity in evaluating the segments were compared. Cohen's Kappa (κ) for diagnosed liver segments and Intra-class Correlation Coefficients (ICC) for the number of metastatic lesions in each patient were calculated. The radiologists' sensitivity and specificity for the CT vs. MRI were, respectively: Reader A-94.4%, 90.3% vs. 96.6%, 94.8%; B-86.7%, 79.7% vs. 83.9%, 82.0%; C-78.0%, 76.7% vs. 83.3%, 78.9% and D-71.8%, 79.2% vs. 64.0%, 69.5%. Reviewers A and B achieved greater agreement in assessing results from the MRI (κ = 0.72, p < 0.001; ICC = 0.73, p < 0.001) vs. the CT (κ = 0.58, p < 0.001; ICC = 0.61, p < 0.001), in contrast to readers C and D (MRI: κ = 0.34, p < 0.001; ICC = 0.42, p < 0.001, and CT: κ = 0.48, p < 0.001; ICC = 0.59, p < 0.001). Our results indicate that the accurate diagnosis of LM of PDAC depends more on radiologic experience in MRI over CT scans.
    Jun. 2020, Cancers, 12(6) (6), English, International magazine
    [Refereed]
    Scientific journal

  • Hayato Kaida, Takahiro Kumode, Masatomo Kimura, Kazunari Ishii
    An 80-year-old woman experienced dyspnea. Cardiac enlargement was detected by chest radiography at a local hospital. She was admitted to our hospital, and echocardiography and CT revealed pericardial effusion and multiple tumor lesions in right atrium. F-FDG PET/CT demonstrated multiple nodular accumulations in these tumors (SUVmax, 14.5). Cytologic analysis of the pericardial fluid revealed a diffuse large B-cell lymphoma. Primary cardiac lymphoma (PCL) is rare, and there are few reports about the F-FDG PET/CT imaging features of PCLs. In high F-FDG uptake in multiple tumors in the right atrium and large pericardial effusion, a PCL should be considered.
    Apr. 2020, Clinical nuclear medicine, 45(4) (4), 319 - 321, English, International magazine
    [Refereed]
    Scientific journal

  • Ayako Suzuki, Nobuo Kashiwagi, Hiroshi Doi, Kazunari Ishii, Katsumi Doi, Mutsukazu Kitano, Takenori Kozuka, Tomoko Hyodo, Masakatsu Tsurusaki, Yukinobu Yagyu, Katsuyuki Nakanishi
    OBJECTIVE: To report clinical features of bone metastases (BM) from head and neck squamous cell carcinoma (HNSCC). METHODS: Among 772 patients with HNSCC diagnosed at our hospital over 9 years, 30 patients (3.9%) had clinical evidence of BM (24 men and 6 women; mean age: 63 years). We assessed the time interval from the primary diagnosis to BM development, symptoms attributable to BM, presence of distant metastases to other organs, number of BM, sites of BM, morphologic changes on computed tomography (CT) images, treatment for BM, and overall survival (OS). RESULTS: BM at the initial stage were found in 9 patients with HNSCC (30%), and in 21 patients (70%) with HNSCC during the course of the disease. In the later patients, the median time interval from the primary diagnosis was 11.5 months. Nineteen patients (63%) did not have BM-related symptoms, 6 (20%) had pain, 3 (10%) had neurologic symptoms resulting from vertebral or skull metastases, and 2 (7%) had hypercalcemia. Seventeen patients (57%) showed bone-exclusive metastases, and 13 (43%) had distant metastases in other organs. Eleven patients (37%) had monostotic metastases (solitary BM), and 19 patients (63%) had polyostotic metastases (multiple BM). When combined, 9 patients (30%) showed bone-exclusive and monostotic metastases. The most commonly affected site was the thoracolumbar spine, accounting for 34% of total BM, followed by the pelvis (24%), shoulder and thorax (21%), and the extremities (17%). Notably, metastases to bones above the clavicle (craniofacial bones and cervical spine) accounted for only 3% of all bone lesions. CT images showed variable morphologic patterns with osteolytic type in 17 patients (57%), intertrabecular in 7 (23%), osteoblastic in 4 (13%), and mixed in 2 (7%). Systematic chemotherapy for BM was performed in 19 patients and radiotherapy in 18. The median survival time for patients with bone-exclusive and monostotic metastases was significantly longer than that for patients with multi-organ metastases or polyostotic metastases at 18.2 months vs. 5.7 months (p=0.02). Neither chemotherapy nor radiotherapy extended OS. CONCLUSION: Thirty percent of BM cases from HNSCC showed bone-exclusive and monostotic metastases. These patients tended to show a more favorable prognosis than patients with multi-organ metastases or polyostotic metastases.
    Apr. 2020, Auris, nasus, larynx, 47(2) (2), 262 - 267, English, International magazine
    [Refereed]
    Scientific journal

  • Paulus K Shigwedha, Takahiro Yamada, Kohei Hanaoka, Kazunari Ishii, Yuichi Kimura, Yutaka Fukuoka
    BACKGROUND: The Logan graphical analysis (LGA) algorithm is widely used to quantify receptor density for parametric imaging in positron emission tomography (PET). Estimating receptor density, in terms of the non-displaceable binding potential (BPND), from the LGA using the ordinary least-squares (OLS) method has been found to be negatively biased owing to noise in PET data. This is because OLS does not consider errors in the X-variable (predictor variable). Existing bias reduction methods can either only reduce the bias slightly or reduce the bias accompanied by increased variation in the estimates. In this study, we addressed the bias reduction problem by applying a different regression method. METHODS: We employed least-squares cubic (LSC) linear regression, which accounts for errors in both variables as well as the correlation of these errors. Noise-free PET data were simulated, for 11C-carfentanil kinetics, with known BPND values. Statistical noise was added to these data and the BPNDs were re-estimated from the noisy data by three methods, conventional LGA, multilinear reference tissue model 2 (MRTM2), and LSC-based LGA; the results were compared. The three methods were also compared in terms of beta amyloid (A β) quantification of 11C-Pittsburgh compound B brain PET data for two patients with Alzheimer's disease and differing A β depositions. RESULTS: Amongst the three methods, for both synthetic and actual data, LSC was the least biased, followed by MRTM2, and then the conventional LGA, which was the most biased. Variations in the LSC estimates were smaller than those in the MRTM2 estimates. LSC also required a shorter computational time than MRTM2. CONCLUSIONS: The results suggest that LSC provides a better trade-off between the bias and variability than the other two methods. In particular, LSC performed better than MRTM2 in all aspects; bias, variability, and computational time. This makes LSC a promising method for BPND parametric imaging in PET studies.
    Feb. 2020, BMC medical imaging, 20(1) (1), 15 - 15, English, International magazine
    [Refereed]
    Scientific journal

  • Takahiro Yamada, Shogo Watanabe, Takashi Nagaoka, Mitsutaka Nemoto, Kohei Hanaoka, Hayato Kaida, Kazunari Ishii, Yuichi Kimura
    Feb. 2020, ANNALS OF NUCLEAR MEDICINE, 34(2) (2), 102 - 107, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Yusuke Okada, Takashi Kato, Kaori Iwata, Yasuyuki Kimura, Akinori Nakamura, Hideyuki Hattori, Hiroshi Toyama, Kazunari Ishii, Kenji Ishii, Michio Senda, Kengo Ito, Takeshi Iwatsubo
    OBJECTIVE: The objectives of the present study were to investigate (1) whether trinary visual interpretation of amyloid positron emission tomography (PET) imaging (negative/equivocal/positive) reflects quantitative amyloid measurements and the time course of 11C-Pittsburgh compound B (PiB) amyloid accumulation, and (2) whether visually equivocal scans represent an early stage of the Alzheimer's disease (AD) continuum in terms of an intermediate state of quantitative amyloid measurements and the changes in amyloid accumulation over time. METHODS: From the National Bioscience Database Center Human Database of the Japanese Alzheimer's Disease Neuroimaging Initiative, we selected 133 individuals for this study including 33 with Alzheimer's disease dementia (ADD), 52 with late mild cognitive impairment (LMCI), and 48 cognitively normal (CN) subjects who underwent clinical assessment, PiB PET, and structural magnetic resonance imaging (MRI) with 2 or 3-years of follow-up. Sixty-eight of the 133 individuals underwent cerebrospinal fluid amyloid-β1-42 (CSF-Ab42) analysis at baseline. The standard uptake value ratio (SUVR) of PiB PET was calculated with a method using MRI at each visit. The cross-sectional values, longitudinal changes in SUVR, and baseline CSF-Ab42 were compared among groups, which were categorized based on trinary visual reads of amyloid PET (negative/equivocal/positive). RESULTS: From the trinary visual interpretation of the PiB PET images, 55 subjects were negative, 8 were equivocal, and 70 were positive. Negative interpretation was most frequent in the CN group (70.8/10.4/18.8%: negative/equivocal/positive), and positive was most frequent in the LMCI group (34.6/1.9/63.5%) and in the ADD group (9.1/6.1/84.8%). The baseline SUVRs were 1.08 ± 0.06 in the negative group, 1.23 ± 0.15 in the equivocal group, and 1.86 ± 0.31 in the positive group (F = 174.9, p < 0.001). The baseline CSF-Ab42 level was 463 ± 112 pg/mL in the negative group, 383 ± 125 pg/mL in the equivocal group, and 264 ± 69 pg/mL in the positive group (F = 37, p < 0.001). Over the 3-year follow-up, annual changes in SUVR were - 0.00 ± 0.02 in the negative group, 0.02 ± 0.02 in the equivocal group, and 0.04 ± 0.07 in the positive group (F = 8.4, p < 0.001). CONCLUSIONS: Trinary visual interpretation (negative/equivocal/positive) of amyloid PET imaging reflects quantitative amyloid measurements evaluated with PET and the CSF amyloid test as well as the amyloid accumulation over time evaluated with PET over 3 years. Subjects in the early stage of the AD continuum could be identified with an equivocal scan, because they showed intermediate quantitative amyloid PET, CSF measurements, and the amyloid accumulation over time.
    Feb. 2020, Annals of nuclear medicine, 34(2) (2), 108 - 118, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Masahiko Takaya, Kazunari Ishii, Isao Kubota, Osamu Shirakawa
    BACKGROUND: The Landscape Montage Technique was originally developed by Hisao Nakai, a Japanese psychiatrist, to pursue the possibility and application of a psychotherapeutic approach using drawing for patients with schizophrenia. Drawing was initially adopted to evaluate patients with an impaired ability for verbal expression, particularly for the diagnosis and treatment of patients with schizophrenia. Since its development, the Landscape Montage Technique has been utilized in various clinical settings throughout Japan. This study aimed to evaluate the psychiatric conditions of a patient diagnosed as having primary progressive aphasia using the Landscape Montage Technique at a 3-year follow-up. CASE PRESENTATION: We present the case of a 64-year-old, right-handed Japanese woman initially diagnosed as having logopenic variant primary progressive aphasia or logopenic aphasia. At a 3-year follow-up, logopenic aphasia progressed to behavioral variant frontotemporal dementia or frontotemporal dementia. According to her husband, she began to have speech difficulties approximately 5 years before her first visit. The results of neurocognitive tests suggested mild cognitive impairment or early stages of dementia. Her clinical dementia rating score was 0.5, suggesting a diagnosis of mild cognitive impairment. She had a Raven's Colored Progressive Matrices score of 31 out of 36, which indicated a nonverbal cognitive ability that was greater than the 90th percentile for her age. The Japanese Standard Language Test of Aphasia, which was performed at two points during the follow-up, indicated the possibility for a diagnosis of primary progressive aphasia given the progression of her aphasia. Based on her clinical symptoms and Japanese Standard Language Test of Aphasia results, a diagnosis of logopenic variant primary progressive aphasia was established. Magnetic resonance imaging revealed severe predominant left frontal and anterior temporal atrophy, as well as bilateral parietal atrophy. Amyloid beta deposition was negative. At the 3-year follow-up, logopenic variant primary progressive aphasia had progressed to behavioral variant frontotemporal dementia. However, the Landscape Montage Technique allowed for the diagnosis of behavioral variant frontotemporal dementia only 2 years after baseline. CONCLUSIONS: The present study showed that the Landscape Montage Technique can be useful for diagnosing behavioral variant frontotemporal dementia that starts as logopenic variant primary progressive aphasia at earlier stages.
    Jan. 2020, Journal of medical case reports, 14(1) (1), 5 - 5, English, International magazine
    [Refereed]
    Scientific journal

  • Mika Yamamuro, Yoshiyuki Asai, Naomi Hashimoto, Nao Yasuda, Koji Yamada, Yoshiaki Ozaki, Kazunari Ishii, Yongbum Lee
    2020, 15TH INTERNATIONAL WORKSHOP ON BREAST IMAGING (IWBI2020), 11513, English
    International conference proceedings

  • Mika Yamamuro, Yoshiyuki Asai, Naomi Hashimoto, Nao Yasuda, Kenta Sakaguchi, Tatsuo Konishi, Koji Yamada, Yoshiaki Ozaki, Kazunari Ishii, Yougbum Lee
    2020, 15TH INTERNATIONAL WORKSHOP ON BREAST IMAGING (IWBI2020), 11513, English
    International conference proceedings

  • Hiroshi Matsuda, Kengo Ito, Kazunari Ishii, Eku Shimosegawa, Hidehiko Okazawa, Masahiro Mishina, Sunao Mizumura, Kenji Ishii, Kyoji Okita, Yoko Shigemoto, Takashi Kato, Akinori Takenaka, Hayato Kaida, Kohei Hanaoka, Keiko Matsunaga, Jun Hatazawa, Masamichi Ikawa, Tetsuya Tsujikawa, Miyako Morooka, Kenji Ishibashi, Masashi Kameyama, Tensho Yamao, Kenta Miwa, Masayo Ogawa, Noriko Sato
    Background: In clinical practice, equivocal findings are inevitable in visual interpretation of whether amyloid positron emission tomography (PET) is positive or negative. It is therefore necessary to establish a more objective quantitative evaluation method for determining the indication for disease-modifying drugs currently under development. Aims: We aimed to determine cutoffs for positivity in quantitative analysis of 18F-flutemetamol PET in patients with cognitive impairment and suspected Alzheimer's disease (AD). We also evaluated the clinical efficacy of amyloid PET in the diagnosis of AD. This study was registered in the Japan Registry of Clinical Trials (jRCTs, 031180321). Methods: Ninety-three patients suspected of having AD underwent 18F-flutemetamol PET in seven institutions. A PET image for each patient was visually assessed and dichotomously rated as either amyloid-positive or amyloid-negative by two board-certified nuclear medicine physicians. If the two readers obtained different interpretations, the visual rating was rerun until they reached consensus. The PET images were quantitatively analyzed using the standardized uptake value ratio (SUVR) and standardized Centiloid (CL) scale with the whole cerebellum as a reference area. Results: Visual interpretation obtained 61 positive and 32 negative PET scans. Receiver operating characteristic analysis determined the best agreement of quantitative assessments and visual interpretation of PET scans to have an area under curve of 0.982 at an SUVR of 1.13 and a CL of 16. Using these cutoff values, there was high agreement between the two approaches (kappa = 0.88). Five discordant cases had SUVR and CL values ranging from 1.00 to 1.22 and from 1 to 26, respectively. In these discordant cases, either diffuse or mildly focal elevation of cortical activity confused visual interpretation. The amyloid PET outcome significantly altered the diagnosis of AD (χ2 = 51.3, p < 0.0001). PET imaging elevated the proportions of the very high likelihood category from 20.4 to 46.2% and the very low likelihood category from 0 to 22.6%. Conclusion: Quantitative analysis of amyloid PET using 18F-flutemetamol can objectively evaluate amyloid positivity using the determined cutoffs for SUVR and CL. Moreover, amyloid PET may have added value over the standard diagnostic workup in dementia patients with cognitive impairment and suspected AD.
    2020, Frontiers in neurology, 11, 578753 - 578753, English, International magazine
    Scientific journal

  • Koichi Miyazaki, Kohei Hanaoka, Hayato Kaida, Yasutaka Chiba, Kazunari Ishii
    OBJECTIVE: The aim was to examine the association between connectivity changes in the default mode network (DMN) and the progression of idiopathic normal pressure hydrocephalus (iNPH). METHODS: We retrospectively recruited cases of preclinical and clinical iNPH from 2,196 patients who had received whole-body 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) scanning. We included 31 cases with asymptomatic ventriculomegaly with features of iNPH on MRI (AVIM; reported as preclinical iNPH) and 12 with iNPH. We performed a voxel-based analysis of the brain FDG-PET images of the AVIM and iNPH groups as well as for each background-matched normal control (NC) group, using Statistical Parametric Mapping 12. Volume of interest (VOI)-based analysis was also performed. We set the VOI as the region from the precuneus to the posterior cingulate cortices (PCC), and compared the mean regional standardized uptake value ratio (SUVR) between the AVIM and iNPH group FDG-PET/CT images and each corresponding NC group. RESULTS: The voxel-based analysis showed a greater decreased FDG uptake in the PCC in the iNPH group than in the AVIM group. The VOI-based analysis revealed no significant difference in the mean SUVR of the AVIM group and the corresponding NC group, but that of the iNPH group was significantly lower than that of its corresponding NC group. CONCLUSIONS: DMN connectivity was reduced in the clinical iNPH group but not in the preclinical group. These data suggest that alterations in the functional connectivity of the DMN are related to the onset of iNPH symptoms.
    2020, Dementia and geriatric cognitive disorders, 49(3) (3), 255 - 263, English, International magazine
    [Refereed]
    Scientific journal

  • Leonie Beyer, Matthias Brendel, Franziska Scheiwein, Julia Sauerbeck, Chisa Hosakawa, Ian Alberts, Kuangyu Shi, Peter Bartenstein, Kazunari Ishii, John Seibyl, Paul Cumming, Axel Rominger
    BACKGROUND: Amyloid-β (Aβ) accumulation in brain of patients with suspected Alzheimer's disease (AD) can be assessed by positron emission tomography (PET) in vivo. While visual classification prevails in the clinical routine, semiquantitative PET analyses may enable more reliable evaluation of cases with a visually uncertain, borderline Aβ accumulation. OBJECTIVE: We evaluated different analysis approaches (visual/semiquantitative) to find the most accurate and sensitive interpretation of Aβ-PET for predicting risk of progression from mild cognitive impairment (MCI) to AD. METHODS: Based on standard uptake value (SUV) ratios of a cortical-composite volume of interest of 18F-AV45-PET from MCI subjects (n = 396, ADNI database), we compared three different reference region (cerebellar grey matter, CBL; brainstem, BST; white matter, WM) normalizations and the visual read by receiver operator characteristics for calculating a hazard ratio (HR) for progression to Alzheimer's disease dementia (ADD). RESULTS: During a mean follow-up time of 45.6±13.0 months, 28% of the MCI cases (110/396) converted to ADD. Among the tested methods, the WM reference showed best discriminatory power and progression-risk stratification (HRWM of 4.4 [2.6-7.6]), but the combined results of the visual and semiquantitative analysis with all three reference regions showed an even higher discriminatory power. CONCLUSION: A multi-analytical composite of visual and semiquantitative reference tissue analyses of 18F-AV45-PET gave improved risk stratification for progression from MCI to ADD relative to performance of single read-outs. This optimized approach is of special interest for prospective treatment trials, which demand a high accuracy.
    2020, Journal of Alzheimer's disease : JAD, 74(1) (1), 101 - 112, English, International magazine
    [Refereed]
    Scientific journal

  • Morimoto D, Hyodo T, Kamata K, Kadoba T, Itoh M, Fukushima H, Chiba Y, Takenaka M, Mochizuki T, Ueda Y, Miyagoshi K, Kudo M, Ishii K
    Jan. 2020, Abdominal Radiology, [Epub ahead of print], English
    [Refereed]
    Scientific journal

  • Kazunari Ishii
    Neuroimaging can provide important biomarkers and is very useful for supporting dementia diagnosis. This review summarizes the neuroimaging findings of dementia with Lewy bodies (DLB), frontotemporal lobar degeneration (FTLD), and normal pressure hydrocephalus (NPH). In DLB, medial temporal atrophy is milder than that of Alzheimer's disease. 2-fluoro-2-deoxy-D-glucose-positron emission tomography and brain perfusion single-photon emission computed tomography demonstrate hypometabolism and hypoperfusion in the occipital lobe, in addition to decreased metabolism and perfusion in the parietotemporal, posterior cingulate, precuneus, and frontal association cortices. The cingulate island sign, which shows relatively spared middle-to-posterior cingulate cortex metabolism compared with precuneus hypometabolism, is proposed to detect DLB in 2-fluoro-2-deoxy-D-glucose-positron emission tomography imaging. Reduced uptake in dopamine transporter imaging and reduced myocardial uptake in iodine-123 metaiodobenzylguanidine cardiac scintigraphy are indicative biomarkers for DLB diagnosis. Characteristic findings of FTLD include dominant frontotemporal atrophy, hypometabolism, and hypoperfusion. Most idiopathic NPH cases demonstrate disproportionally enlarged subarachnoid space hydrocephalus findings, including dilated ventricular systems, enlarged Sylvian fissures, tight sulci in the midline, and a high convexity.
    Springer Science and Business Media {LLC}, Jan. 2020, Japanese Journal of Radiology, 38(1) (1), 64 - 76, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Hayato Kaida, Koichi Azuma, Akihiko Kawahara, Shinzo Takamori, Jun Akiba, Kiminori Fujimoto, Kazunari Ishii, Masatoshi Ishibashi
    OBJECTIVE: To investigate the relationship between the prognosis and glucose transporter-1 (Glut-1) expression or fluorine-18 fluorodeoxyglucose uptake using partial volume correction and dual-point imaging in surgically resected nonsmall cell lung cancer (NSCLC) patients. METHODS: Our patient population consisted of 108 NSCLC cases. The early maximum standardized uptake value (ESUVmax), delayed SUVmax (DSUVmax), partial volume correction SUVmax (cSUVmax) and retention index of primary lesions were calculated. Cox proportional hazard model was applied to evaluate the effects of PET parameters and Glut-1 expression. Overall survival (OS) and disease-free survival (DFS) were evaluated by Kaplan-Meier methods, and the difference in survival between subgroups was analyzed by log-rank test. RESULTS: On the Cox regression analysis, ESUVmax, DSUVmax, cSUVmax and Glut-1 were significantly related to DFS [ESUVmax, hazard ratio = 2.301, 95% confidential interval (CI) = 1.146-4.618, P = 0.019; DSUVmax, hazard ratio = 2.483, 95% CI = 1.257-4.905, P = 0.009; cSUVmax, hazard ratio = 2.205, 95% CI = 1.038-4.686, P = 0.04; Glut-1, hazard ratio = 2.095, 95% CI = 1.086-4.041, P = 0.001] and OS (ESUVmax, hazard ratio = 3.197, 95% CI = 1.339-7.633, P = 0.009; DSUVmax, hazard ratio = 3.599, 95% CI = 1.521-8.516, P = 0.004; cSUVmax, hazard ratio = 8.655, 95% CI = 2.048-36.658, P = 0.003; Glut-1, hazard ratio = 2.427, 95% CI = 5.140, P = 0.021). Retention index had no significant association with DFS or OS. On the Kaplan-Meier survival curves, the patients with high ESUVmax, DSUVmax, cSUVmax and Glut-1 showed significantly worse prognosis than those with low values (ESUVmax: DFS, P = 0.001, OS, P = 0.003; DSUVmax: DFS, P = 0.002, OS, P = 0.004; cSUVmax: DFS, P < 0.001, OS, P = 0.013; Glut-1: DFS, P = 0.012, OS, P = 0.002). CONCLUSIONS: cSUVmax, ESUVmax, DSUVmax and Glut-1 may be more useful biomarkers than retention index for predicting outcomes in NSCLC patients.
    Jan. 2020, Nuclear medicine communications, 41(1) (1), 48 - 57, English, International magazine
    [Refereed]
    Scientific journal

  • Koichi Miyazaki, Kohei Hanaoka, Hayato Kaida, Yasutaka Chiba, Kazunari Ishii
    BACKGROUND: Decreased cerebral glucose metabolism has been reported in idiopathic normal pressure hydrocephalus (iNPH). However, the timing of appearance in the preclinical stage of iNPH remains unknown. Herein, we evaluated the changes in regional cerebral glucose metabolism with respect to the characteristic morphologic features of iNPH. METHODS: We performed a cross-sectional study in > 2000 elderly patients who received a whole body 18F-fluorodeoxyglucose-positron emission tomography/computed tomography scanning and recruited subjects with clinical and preclinical iNPH. We included 12 subjects with iNPH, 32 subjects with asymptomatic ventriculomegaly with features of iNPH on magnetic resonance imaging (AVIM), and 33 subjects with preclinical morphologic features of DESH (PMD). We previously reported that iNPH develops in the order of PMD (asymptomatic subjects with incomplete DESH), AVIM (asymptomatic subjects with DESH), and iNPH (symptomatic subjects with DESH). We measured the median regional standardized uptake value ratio (SUVR) on 18F-fluorodeoxyglucose-positron emission tomography/computed tomography images between the three groups and compared them with background-matched normal controls in the frontal lobes, temporal lobes, medial parietal lobes, striata, and thalami. RESULTS: In the frontal and temporal lobes, the SUVR distributions of the PMD, AVIM, and PMD groups were significantly lower than for each NC (p < 0.05 for all). In the medial parietal lobes, the SUVR distributions were significantly higher in PMD and AVIM groups (p < 0.05 for all). In the thalami and striata, the SUVR distributions were significantly lower in the iNPH group (p < 0.05 for all). CONCLUSIONS: Changes in brain glucose metabolism in the cortices are observed in preclinical iNPH, while metabolic decline in the basal ganglia is only detected in clinical iNPH.
    Dec. 2019, EJNMMI research, 9(1) (1), 111 - 111, English, International magazine
    [Refereed]
    Scientific journal

  • Koichi Miyazaki, Kazunari Ishii, Kohei Hanaoka, Hayato Kaida, Koichi Nakajima
    Disproportionately enlarged subarachnoid-space hydrocephalus (DESH) findings are often reported as characteristic radiological features of idiopathic normal pressure hydrocephalus (iNPH). However, the process of development of DESH remains unclear. The aim of the present study was to determine the dynamic deforming process and pathophysiology of iNPH. All patients >50 years of age who underwent whole body FDG-PET/CT scanning at Kindai University Hospital between May 2017 and April 2018 were included in this retrospective study, and their brain image findings and clinical information were assessed. We defined DESH-like findings, which had one or two equivocal features of the three components of DESH findings, as preclinical morphologic features of DESH (PMD). PMD were classified into six subtypes based on their component of DESH findings: PMD-T, only tight medial and high convexity subarachnoid spaces (TMC); PMD-S, only enlarged Sylvian fissures; PMD-V, only ventriculomegaly; PMD-TV, TMC and ventriculomegaly; PMD-TS, TMC and enlarged Sylvian fissures; PMD-SV, enlarged Sylvian fissures and ventriculomegaly. A total of 2196 cases (70.5 ± 9.3 years) were enrolled, with 54 cases (77.1 ± 5.9 years) with DESH findings, and 42 cases (72.9 ± 7.9 years) with PMD (five PMD-T, two PMD-V, 12 PMD-TV, 18 PMD-TS, and five PMD-SV). In each component of DESH, 35 of 42 (83.3%) cases with PMD had TMC. We suggest that the TMC is the first change on DESH findings in most iNPH cases, and may be an important part of the pathophysiology of iNPH.
    Nov. 2019, Neurologia medico-chirurgica, 59(11) (11), 436 - 443, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Diagnostic Utility of Cardiac Magnetic Resonance/F-18-fluorodeoxyglcose Positron Emission Tomography Fusion Imaging in Cardiac Sarcoidosis
    Masakazu Yasuda, Yoshinori Kagioka, Mana Okune, Kakehi Kazuyoshi, Takayuki Kawamura, Hayato Kaida, Kazunari Ishii, Yoshitaka Iwanaga
    Nov. 2019, CIRCULATION, 140, English

  • Takashi Suehiro, Hiroaki Kazui, Hideki Kanemoto, Kenji Yoshiyama, Shunsuke Sato, Yukiko Suzuki, Shingo Azuma, Takuya Matsumoto, Haruhiko Kishima, Kazunari Ishii, Manabu Ikeda
    BACKGROUND: Specific ventriculomegaly features, including tight high-convexity and medial subarachnoid spaces, are found on magnetic resonance images in patients with idiopathic normal pressure hydrocephalus (iNPH). However, some healthy elderly individuals with no typical triad symptoms of iNPH also exhibit specific magnetic resonance image features of iNPH. Therefore, this study quantitatively clarified the brain morphology of suspected iNPH patients with no objective triad symptoms (iNPH-NOS). METHODS: We recruited patients with suspected iNPH and divided them into two groups based on their iNPH grading scale scores: the iNPH-NOS group and the iNPH with apparent objective triad symptoms (iNPH-AOS) group. Data for normal controls (NC) were taken from the database used in our previous study. We compared the relative volumes of ventricle systems (VS), Sylvian fissures (SF), and sulci at high convexity and the midline (SHM), adjusted by the intracranial volume, of the iNPH-NOS, iNPH-AOS, and NC groups. Additionally, we compared the relative volumes of VS, SF, and SHM in iNPH-NOS patients between their first visit and follow-up 1 year later. RESULTS: Fifteen iNPH-NOS patients and 45 iNPH-AOS patients were recruited, and 24 NCs were found in the database. The relative volumes of VS and SF were significantly smaller than in NCs than in the iNPH-NOS and iNPH-AOS groups, and the relative volume of SHM was significantly larger in NCs. The relative volume of SHM was significantly larger in the iNPH-NOS group than in the iNPH-AOS group, but there were no significant differences in the relative volumes of VS and SF between these groups. In the iNPH-NOS group, the relative volumes of VS and SF were significantly smaller at the first visit than 1 year later, whereas the relative volume of SHM was significantly larger. In 6 of 15 iNPH-NOS patients, objective symptoms appeared during the observation period. CONCLUSIONS: Our results indicate that iNPH-NOS patients were in the transitional stage between normal and iNPH-AOS, both morphologically and clinically.
    Nov. 2019, Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 19(6) (6), 557 - 565, English, International magazine
    [Refereed]
    Scientific journal

  • アミロイドPET病理陽性率に対するAPOE4の影響 J-ADNI研究(The effect of APOE4 to the amytoid PET positive rate: A J-ADNI Study)
    岡田 佑介, 加藤 隆司, 木村 泰之, 中村 昭範, 服部 英幸, 外山 宏, 石井 一成, 石井 賢二, 千田 道雄, 伊藤 健吾, 岩坪 威
    (一社)日本核医学会, Oct. 2019, 核医学, 56(Suppl.) (Suppl.), S174 - S174, English

  • MRI、FDG画像で解剖学的標準化する方法とCapAIBLとのアミロイドPET SUVR値の比較検討
    竹中 章倫, 岡田 佑介, 岩田 香織, 加藤 隆司, 木村 泰之, 中村 昭範, 石井 一成, 石井 賢二, 千田 道雄, 伊藤 健吾, 岩坪 威
    (一社)日本核医学会, Oct. 2019, 核医学, 56(Suppl.) (Suppl.), S174 - S174, Japanese

  • 当施設で開発したPiB PET皮質平均SUVR値の算出法とCapAIBLとの互換性の検討
    竹中 章倫, 岡田 佑介, 岩田 香織, 加藤 隆司, 木村 泰之, 中村 昭範, 外山 宏, 石井 一成, 石井 賢二, 千田 道雄, 伊藤 健吾, 岩坪 威
    (一社)日本認知症学会, Oct. 2019, Dementia Japan, 33(4) (4), 553 - 553, Japanese

  • 【認知症の画像診断〜ルーチン検査から最新の画像検査まで〜】認知症の画像検査 Brain Imaging in Dementia
    花岡 宏平, 石井 一成
    (株)メディカルアイ, Oct. 2019, Rad Fan, 17(13) (13), 13 - 17, Japanese

  • AI異常検知に基づくPET/CT上の頸胸部病変の自動認識
    田中 敦子, 根本 充貴, 甲斐田 勇人, 木村 裕一, 山田 誉大, 牛房 和之, 花岡 宏平, 北島 一宏, 槌谷 達也, 石井 一成
    (一社)日本核医学会, Oct. 2019, 核医学, 56(Suppl.) (Suppl.), S154 - S154, Japanese

  • FDG PET/CTによる食道癌術前化学療法の治療効果判定に関する検討
    甲斐田 勇人, 白石 治, 岩間 密, 加藤 寛章, 木村 豊, 花岡 宏平, 山田 穣, 北島 一宏, 安田 卓司, 石井 一成
    (一社)日本核医学会, Oct. 2019, 核医学, 56(Suppl.) (Suppl.), S155 - S155, English

  • 認知症自動診断AIアルゴリズム学習のための深層学習によるアミロイド画像の加増手法の検討
    渡邉 綾, 山田 誉大, 永岡 隆, 根本 充貴, 花岡 宏平, 甲斐田 勇人, 石井 一成, 木村 裕一
    (一社)日本核医学会, Oct. 2019, 核医学, 56(Suppl.) (Suppl.), S178 - S178, Japanese

  • Go Akamatsu, Yasuhiko Ikari, Akihito Ohnishi, Keiichi Matsumoto, Hiroyuki Nishida, Yasuji Yamamoto, Michio Senda
    BACKGROUND: Amyloid PET plays a vital role in detecting the accumulation of in vivo amyloid-β (Aβ). The quantification of Aβ accumulation has been widely performed using the region of interest (ROI)-based mean cortical standardized uptake value ratio (mcSUVR). However, voxel-based statistical analysis has not been well studied. The purpose of this study was to examine the feasibility of analyzing amyloid PET scans by voxel-based statistical analysis. The results were then compared to those with the ROI-based mcSUVR. In total, 166 subjects who underwent 11C-PiB PET in the J-ADNI multi-center study were analyzed. Additionally, 18 Aβ-negative images were collected from other studies to form a normal database. The PET images were spatially normalized to the standard space using an adaptive template method without MRI. The mcSUVR was measured using a pre-defined ROI. Voxel-wise Z-scores within the ROI were calculated using the normal database, after which Z-score maps were generated. A receiver operating characteristic (ROC) analysis was performed to evaluate whether Z-sum (sum of the Z-score) and mcSUVR could be used to classify the scans into positive and negative using the central visual read as the reference standard. PET scans that were equivocal were regarded as positive. RESULTS: Sensitivity and specificity were respectively 90.8% and 100% by Z-sum and 91.8% and 98.5% by mcSUVR. Most of the equivocal scans were subsequently classified by both Z-sum and mcSUVR as false negatives. Z-score maps correctly delineated abnormal Aβ accumulation over the same regions as the visual read. CONCLUSIONS: We examined the usefulness of voxel-based statistical analysis for amyloid PET. This method provides objective Z-score maps and Z-sum values, which were observed to be helpful as an adjunct to visual interpretation especially for cases with mild or limited Aβ accumulation. This approach could improve the Aβ detection sensitivity, reduce inter-reader variability, and allow for detailed monitoring of Aβ deposition. TRIAL REGISTRATION: The number of the J-ADNI study is UMIN000001374.
    Sep. 2019, EJNMMI research, 9(1) (1), 91 - 91, English, International magazine
    Scientific journal

  • 肝細胞癌術後胆汁瘻に対し経皮的アプローチと内視鏡的アプローチを組み合わせてステント留置を施行した1例
    鈴木 絢子, 沼本 勲男, 鶴崎 正勝, 小田 晃義, 門場 智也, 柳生 行伸, 石井 一成, 岡本 彩那, 三長 孝輔, 岩崎 寿光
    (一社)日本インターベンショナルラジオロジー学会, Sep. 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(1) (1), 79 - 79, Japanese

  • 松久保 祐子, 松木 充, 若菜 みゆき, 鈴木 絢子, 浜川 岳文, 沼本 勲男, 門場 智也, 兵頭 朋子, 鶴崎 正勝, 石井 一成
    (株)学研メディカル秀潤社, Sep. 2019, 画像診断, 39(12) (12), 1308 - 1322, Japanese

  • Shuhei Doi, Nobuo Kashiwagi, Takao Satou, Hayato Kaida, Kazunari Ishii
    Previous studies have reported increased Pittsburgh compound-B (PiB) uptake in meningiomas; however, histological correlation to elucidate the underlying mechanism has not yet been done. We report a case of an 82-year-old woman with an incidental intracranial tumor that showed focal increased PiB uptake. Because of tumor growth, surgical resection was performed, yielding a histological diagnosis of meningioma. Any special and immunochemical staining for amyloid did not reveal amyloid deposition in the tumor. Our findings suggest that increased PiB uptake was not associated with amyloid in this instance.
    Jul. 2019, Clinical nuclear medicine, 44(7) (7), 587 - 588, English, International magazine
    [Refereed]
    Scientific journal

  • Nobuo Kashiwagi, Tomoko Hyodo, Kazunari Ishii, Osamu Maenishi, Eisuke Enoki, Takaaki Chikugo, Tsurusaki Masakatsu, Yukinobu Yagyu, Mutsukazu Kitano, Noriyuki Tomiyama
    OBJECTIVES: To report MRI findings of spontaneous infarction in parotid tumours. METHODS: 14 patients (13 male, 1 female; mean age 73 years) with spontaneously infarcted parotid tumours were reviewed retrospectively. MR images were assessed for the location, the presence of synchronous parotid masses, margin characteristics, signal intensity on T1 and T2 weighted images, and internal architecture according to the distribution of T2 signal hyperintensity. RESULTS: 12 tumours were located in the parotid tail and 2 in the superficial lobe. Synchronous parotid masses were seen in four tumours, three of which were located in the ipsilateral parotid tail and one in the contralateral parotid tail. Seven tumours had well-defined margins and seven had ill-defined margins. The signal intensities on T1 weighted images were a mixture of high and intermediate in all cases; in 11 tumours, hyperintense areas were dominant. On T2 weighted images, all tumours also showed a mixture of high and intermediate signal intensities. Internal architectures on T2 weighted images were mosaic hyperintensity in three tumours, central hyperintensity in five, and multiseparated hyperintensity in six. CONCLUSIONS: Spontaneously infarcted parotid tumours were mostly located in the parotid tail and showed mixed signal intensities with predominant hyperintensity on T1 weighted images. Half of the tumours had ill-defined margins, and the internal architectures varied.
    Jul. 2019, Dento maxillo facial radiology, 48(5) (5), 20180382 - 20180382, English, International magazine
    [Refereed]
    Scientific journal

  • Masahiko Takaya, Kazunari Ishii, Isao Kubota, Osamu Shirakawa
    Jul. 2019, Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 19(4) (4), 399 - 401, English, International magazine
    [Refereed]
    Scientific journal

  • 心筋SPECTと冠動脈CTの融合画像作成における技術的注意点と対策について
    吉田 修平, 花岡 宏平, 坂口 健太, 又野 嘉枝子, 安田 昌和, 石井 一成
    日本心臓核医学会, Jun. 2019, 日本心臓核医学会ニュースレター, 21(2) (2), 85 - 85, Japanese

  • Shota Watanabe, Kohei Hanaoka, Yusuke Shibata, Hayato Kaida, Kazunari Ishii
    Mar. 2019, NUCLEAR MEDICINE COMMUNICATIONS, 40(3) (3), 235 - 241, English, International magazine
    [Refereed]
    Scientific journal

  • 肺癌手術にて病理診断されたMultiple minute pulmonary meningothelial-like nodulesの1例
    和田 祐太郎, 松木 充, 土居 秀平, 鈴木 絢子, 沼本 勲男, 小田 晃義, 山田 穣, 兵頭 朋子, 任 誠雲, 甲斐田 勇人, 柳生 行伸, 細川 知紗, 小塚 健倫, 柏木 伸夫, 鶴崎 正勝, 今岡 いずみ, 細野 眞, 石井 一成, 村上 卓道, 榎木 英介
    (公社)日本医学放射線学会, Feb. 2019, Japanese Journal of Radiology, 37(Suppl.) (Suppl.), 40 - 40, Japanese

  • Takuya Yagi, Michio Kanekiyo, Junichi Ito, Ryoko Ihara, Kazushi Suzuki, Atsushi Iwata, Takeshi Iwatsubo, Ken Aoshima
    INTRODUCTION: The objective of this study was to determine the factors including neuropsychological test performances and cerebrospinal fluid (CSF) biomarkers which can predict disease progression of early Alzheimer's disease (AD) in a Japanese population. METHODS: The group classification on early AD population in both Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) and North American ADNI (NA-ADNI) was performed using the inclusion criteria including brain amyloid positivity on positron emission tomography or CSF. Participants with early AD from each cohort were stratified into two groups based on a cutoff 1.0 of Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) change at month 24 (m24): participants in "progress group" have CDR-SB change ≥ 1.0 and participants in "stable group" have CDR-SB change < 1.0. Then, we performed identification of prognostic factors from baseline items including neuropsychological scores (Assessment Scale-Cognitive Subscale[ADAS-cog 13], Mini-Mental State Examination (MMSE), CDR, FAQ, and Geriatric Depression Scale ), CSF markers (t-tau, p-tau, and beta-amyloid 1-42), vital signs (body weight, pulse rate, etc.,), by using two statistical approaches, Welch's t-test and simple linear regression by ordinary least squares. Comparisons between participants with J-ADNI and participants with NA-ADNI were also performed. RESULTS: Trends of CDR-SB changes were very similar between J-ADNI and NA-ADNI early AD population enrolled in this study. Baseline levels of CSF t-tau, p-tau, Mini-Mental State Examination, FAQ, and ADAS-cog13 were identified as prognostic factors in both J-ADNI and NA-ADNI. Based on a detailed subscale analysis on ADAS-cog13, four subscales (Q1: word recall, Q3: construction, Q4: delayed word recall, and Q8: word recognition) were identified as prognostic factors in both J-ADNI and NA-ADNI. DISCUSSION: Characterizing population with early AD can provide benefits for promoting efficiency in conducting AD clinical trials for disease-modifying treatments. Thus, implementing these prognostic factors into clinical trials may be potentially a good method to enrich participants with early AD who are suitable for evaluating treatment effects.
    2019, Alzheimer's & dementia (New York, N. Y.), 5, 364 - 373, English, International magazine
    Scientific journal

  • 甲斐田 勇人, 山田 穣, 松久保 祐子, 花岡 宏平, 任 誠雲, 柳生 行伸, 細野 眞, 石井 一成
    (一社)日本核医学会, 2019, 核医学, 56(1) (1), 153 - 153, Japanese

  • Ryuichi Takahashi, Kazunari Ishii, Takahiko Tokuda, Madoka Nakajima, Takaharu Okada
    PURPOSE: The purpose of this study was to elucidate the specific regional cerebral blood flow (rCBF) alterations for idiopathic normal pressure hydrocephalus (iNPH) by comparing the proportional rCBF and gray matter change from those of a normal database at the same point of SPECT and MRI examinations. METHODS: Thirty subjects with iNPH underwent both CBF SPECT and MRI. After normalization, voxel-wise two-sample t tests between patients and 11 normal controls were conducted to compare the regional alteration in the gray matter density and rCBF. RESULTS: The rCBF reduction and the gray matter decrease were seen in almost similar regions surrounding Sylvian fissure, the left parietotemporal region and frontal lobes, whereas we did not find rCBF increase at the top of the high convexity, where the increase of the gray matter density was the highest (p < 0.05). CONCLUSION: Our study showed regional associations and dissociations between the relative gray matter density and rCBF in patients with iNPH.
    Springer Science and Business Media {LLC}, Jan. 2019, Neuroradiology, 61(1) (1), 37 - 42, English, International magazine
    [Refereed]
    Scientific journal

  • Kaida H, Inui H, Chikugo T, Ishii K
    Jan. 2019, Case reports in oncology, 12(1) (1), 157 - 163
    [Refereed]

  • パーキンソン症候群に対するDAT Z-score画像の臨床応用
    高橋 竜一, 石井 一成, 樫林 哲雄, 丸本 浩平, 多々野 誠, 水田 英二
    (一社)日本神経学会, Dec. 2018, 臨床神経学, 58(Suppl.) (Suppl.), S213 - S213, Japanese
    [Refereed]

  • SPIOを用いた新しいリンパ節転移診断法
    村上幸祐, 鈴木彩子, 佐藤華子, 城玲央奈, 山本貴子, 大須賀拓真, 甲斐冴, 藤島理沙, 青木稚人, 葉宜慧, 貫戸明子, 高矢寿光, 小谷泰史, 中井英勝, 辻勲, 石井一成, 柏木伸夫, 佐藤隆夫, 榎木英介, 松村謙臣
    近畿大学医学会, Dec. 2018, 近畿大学医学雑誌, 43(3-4) (3-4), 17A - 17A, Japanese

  • SRTM法を用いたアミロイドイメージングに対する空間分解能を損なわないノイズ低減アルゴリズムの検討
    山田 誉大, 木村 裕一, 根本 充貴, 坂田 宗之, 永岡 隆, 花岡 宏平, 甲斐田 勇人, 石井 一成
    (一社)日本核医学会, Nov. 2018, 核医学, 55(Suppl.) (Suppl.), S168 - S168, Japanese

  • AI異常検知を用いたFDG-PET/CT上の頸胸部原発性・転移性病変の検出
    根本 充貴, 甲斐田 勇人, 田中 敦子, 牛房 和之, 山田 誉大, 木村 裕一, 花岡 宏平, 石井 一成
    (一社)日本核医学会, Nov. 2018, 核医学, 55(Suppl.) (Suppl.), S196 - S196, Japanese

  • FDG PET/CTによる食道癌術前化学療法の予後解析
    甲斐田 勇人, 白石 治, 岩間 密, 加藤 寛章, 木村 豊, 花岡 宏平, 山田 穣, 北島 一宏, 細野 眞, 安田 卓司, 石井 一成
    (一社)日本核医学会, Nov. 2018, 核医学, 55(Suppl.) (Suppl.), S200 - S200, English

  • 渡邊 翔太, 花岡 宏平, 柴田 侑亮, 石井 一成
    (NPO)日本核医学技術学会, Oct. 2018, 核医学技術, 38(予稿集) (予稿集), 399 - 399, Japanese

  • Hayato Kaida, Koichi Azuma, Akihiko Kawahara, Eiji Sadashima, Satoshi Hattori, Shinzo Takamori, Jun Akiba, Kiminori Fujimoto, Axel Rominger, Takamichi Murakami, Kazunari Ishii, Masatoshi Ishibashi
    Introduction: To assess the correlation among 18F-FDG uptake, Glut1, pStat1 and pStat3, and to investigate the relationship between the prognosis and 18F-FDG uptake and these molecular markers in surgically resected non-small cell lung cancer (NSCLC) patients. Results: Knockdown of Glut1 led to a significant increase in pStat1 expression. Glut1 expression positively correlated with the SUVmax, SUVmean, and TLG significantly (P<0.001). pStat3 expression negatively correlated with all PET parameters significantly (P<0.001). pStat1 had positive weak correlations with the SUVmax and SUVmean. All PET parameters and Glut1 were significantly associated with DFS (P<0.05). TLG, MTV, Glut1 and pStat1 were significantly associated with OS (P<0.05). Conclusion: pStat3 and Glut1 may be associated with 18F-FDG uptake mechanism. TLG, MTV, and Glut1 may be independent prognostic factors. Methods: The SUVmax, SUVmean, MTV and TLG of primary lesions were calculated in 140 patients. The expressions of Glut1 and Stat pathway proteins in NSCLC cell lines were examined by immune blots. Excised tumor tissue was analyzed by immunohistochemistry. OS and DFS were evaluated by the Kaplan-Meier method. The difference in survival between subgroups was analyzed by log-rank test. The prognostic significance of clinicopathological, molecular and PET parameters was assessed by Cox proportional hazard regression analysis.
    Aug. 2018, Oncotarget, 9(62) (62), 31971 - 31984, English, International magazine
    [Refereed]
    Scientific journal

  • Takeshi Iwatsubo, Atsushi Iwata, Kazushi Suzuki, Ryoko Ihara, Hiroyuki Arai, Kenji Ishii, Michio Senda, Kengo Ito, Takeshi Ikeuchi, Ryozo Kuwano, Hiroshi Matsuda, Chung-Kai Sun, Laurel A Beckett, Ronald C Petersen, Michael W Weiner, Paul S Aisen, Michael C Donohue
    INTRODUCTION: We conducted Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) and compared the basic characteristics and progression profiles with those of ADNI in North America. METHODS: A total of 537 Japanese subjects with normal cognition, late amnestic mild cognitive impairment (LMCI), or mild Alzheimer's disease (AD) were enrolled using the same criteria as ADNI. Rates of changes in representative cognitive or functional measures were compared for amyloid positron emission tomography- or cerebrospinal fluid amyloid β(1-42)-positive LMCI and mild AD between J-ADNI and ADNI. RESULTS: Amyloid positivity rates were significantly higher in normal cognition of ADNI but at similar levels in LMCI and mild AD between J-ADNI and ADNI. Profiles of decline in cognitive or functional measures in amyloid-positive LMCI in J-ADNI (n = 75) and ADNI (n = 269) were remarkably similar, whereas those in mild AD were milder in J-ADNI (n = 73) compared with ADNI (n = 230). DISCUSSION: These results support the feasibility of bridging of clinical trials in the prodromal stage of AD between Asia and western countries.
    Aug. 2018, Alzheimer's & dementia : the journal of the Alzheimer's Association, 14(8) (8), 1077 - 1087, English, International magazine
    Scientific journal

  • Yuichi Wakabayashi, Ryuichi Takahashi, Tomonori Kanda, Feibi Zeng, Munenobu Nogami, Kazunari Ishii, Takamichi Murakami
    Aug. 2018, NEUROLOGICAL SCIENCES, 39(8) (8), 1401 - 1407, English, International magazine
    [Refereed]
    Scientific journal

  • Nobuo Kashiwagi, Shin Ichi Nakatsuka, Takamichi Murakami, Eisuke Enoki, Kazuhiro Yamamoto, Katsuyuki Nakanishi, Takaaki Chikugo, Yoshitaka Kurisu, Masatomo Kimura, Tomoko Hyodo, Akio Tsukabe, Takahide Kakigi, Yasuhiko Tomita, Kazunari Ishii, Yoshifumi Narumi, Yukinobu Yagyu, Noriyuki Tomiyama
    OBJECTIVES: To report MR imaging features of mammary analogue secretory carcinoma (MASC) and acinic cell carcinoma (AciCC) of the salivary gland based on the latest version of the World Health Organization (WHO) 2017 classification of head and neck tumours. METHODS: MR images in 4 patients with MASC and 4 with AciCC were reviewed for margin characteristics, the presence of pathological cervical nodes, the presence of a cystic component and interface between cystic and solid component, signal intensity of the cystic components on T1 weighted images, and signal intensity of the solid component on T1 and T2 weighted images. RESULTS: All the MASCs and AciCCs had well-defined boundaries, and 1 AciCC had pathological nodes. All 4 MASCs presented as predominantly cystic tumours with papillary projection of the solid component. All 4 AciCCs presented as solid tumours. The signal intensity of the cystic components on T1 weighted images was entirely hyperintense in 2, and partly hyperintense demonstrating fluid-fluid level in 2. In all the MASCs, the signal intensity of the solid components on T1 weighted images was intermediate. In the AciCCs, the signal intensity of the solid components on T1 weighted images was high in 2 tumours and intermediate in 2. The signal intensity of the solid components on T2 weighted images varied from low to high in both MSACs and AciCCs. CONCLUSIONS: All 4 MASCs had a large cystic component, including areas of high signal intensity on T1 weighted images. The solid component appeared as a papillary projection into the cystic component. All 4 AciCCs presented as solid tumours, 2 of which showed high signal intensity on T1 weighted images.
    Jul. 2018, Dento maxillo facial radiology, 47(5) (5), 20170218 - 20170218, English, International magazine
    [Refereed]
    Scientific journal

  • Julia Sauerbeck, Kazunari Ishii, Chisa Hosokawa, Hayato Kaida, Franziska T. Scheiwein, Kohei Hanaoka, Axel Rominger, Matthias Brendel, Peter Bartenstein, Takamichi Murakami
    PURPOSE: In subjects with amyloid deposition, striatal accumulation of 11C-Pittsburgh compound B (PiB) demonstrated by positron emission tomography (PET) is related to the stage of Alzheimer's disease (AD). In this study, we investigated the correlation between striatal and cortical non-displaceable binding potential (BPND). METHODS: Seventy-three subjects who complained of cognitive disturbance underwent dynamic PiB-PET studies and showed positive PiB accumulation were retrospectively selected. These subjects included 34 AD, 26 mild cognitive impairment, 2 frontotemporal lobar degeneration, 2 Parkinson's disease, 5 dementia with Lewy bodies, and 4 undefined diagnosis patients. Individual BPND images were produced from the dynamic data of the PiB-PET study, and voxel-based analyses were performed to estimate the correlations between striatal and other regional cortical BPND measures. RESULTS: There were highly significant correlations between striatal and prefrontal BPND, with the highest correlation being demonstrated in left Brodmann area 11. We found that almost all of the high cortical BPND values correlated with striatal BPND values, with the exception of the occipital cortex with low correlation. CONCLUSION: Our study demonstrated positive correlations in amyloid deposits between the striatum and other cortical areas with functional and anatomical links. The amyloid distribution in the brain is not random, but spreads following the functional and anatomical connections.
    Springer Science and Business Media {LLC}, Jul. 2018, Annals of Nuclear Medicine, 32(6) (6), 398 - 403, English, Domestic magazine
    [Refereed]
    Scientific journal

  • 柏木 伸夫, 藤原 良平, 甲斐田 勇人, 鶴崎 正勝, 石井 一成
    (株)学研メディカル秀潤社, Jun. 2018, 画像診断, 38(8) (8), 795 - 804, Japanese

  • 鈴木絢子, 沼本勲男, 松木充, 小田晃義, 柳生行伸, 小塚健倫, 石井一成, 榎木英介, 村上卓道
    78歳男。腹部鈍痛を主訴とした。近医にて血液検査で炎症反応高値、汎血球減少、ALP上昇、肝機能障害、腎機能障害を認めた。腹部骨盤CTでは体腔液貯留、肝・副腎腫大、椎体・仙骨・腸骨・大腿骨の骨髄濃度の上昇を認め、腎盂腎炎疑いで4週間加療するも発熱と腹水増加を呈した。紹介受診時には体温38℃で、血液生化学検査所見の改善はみられなかった。胸部・腹部骨盤CTでは胸腹水増加、全身浮腫増悪、全身の多発リンパ腫大を認めた。骨髄生検では原発性骨髄線維症grade MF1相当であった。鼠径リンパ節生検ではhyaline-vascular typeのCastleman病類似の組織像を認めた。TAFRO症候群と診断した。
    金原出版(株), May 2018, 臨床放射線, 63(5) (5), 553 - 557, Japanese

  • Masahiko Takaya, Kazunari Ishii, Chisa Hosokawa, Kazumasa Saigoh, Osamu Shirakawa
    May 2018, INTERNATIONAL PSYCHOGERIATRICS, 30(5) (5), 641 - 646, English, International magazine
    [Refereed]
    Scientific journal

  • Watanabe Shota, Sakaguchi Kenta, Hosono Makoto, Ishii Kazunari, Murakami Takamichi, Ichikawa Katsuhiro

    The purpose of this study was to evaluate the effect of a hybrid-type iterative reconstruction method on Z-score mapping of hyperacute stroke in unenhanced computed tomography (CT) images. We used a hybrid-type iterative reconstruction [adaptive statistical iterative reconstruction (ASiR)] implemented in a CT system (Optima CT660 Pro advance, GE Healthcare). With 15 normal brain cases, we reconstructed CT images with a filtered back projection (FBP) and ASiR with a blending factor of 100% (ASiR100%). Two standardized normal brain data were created from normal databases of FBP images (FBP-NDB) and ASiR100% images (ASiR-NDB), and standard deviation (SD) values in basal ganglia were measured. The Z-score mapping was performed for 12 hyperacute stroke cases by using FBP-NDB and ASiR-NDB, and compared Z-score value on hyperacute stroke area and normal area between FBP-NDB and ASiR-NDB. By using ASiR-NDB, the SD value of standardized brain was decreased by 16%. The Z-score value of ASiR-NDB on hyperacute stroke area was significantly higher than FBP-NDB (p<0.05). Therefore, the use of images reconstructed with ASiR100% for Z-score mapping had potential to improve the accuracy of Z-score mapping.

    Japanese Society of Radiological Technology, Apr. 2018, Japanese Journal of Radiological Technology, 74(4) (4), 375 - 381, Japanese

  • Takuma Ohmichi, Masaki Kondo, Masahiro Itsukage, Hidetaka Koizumi, Shigenori Matsushima, Nagato Kuriyama, Kazunari Ishii, Etsuro Mori, Kei Yamada, Toshiki Mizuno, Takahiko Tokuda
    OBJECTIVE: The gold standard for the diagnosis of idiopathic normal pressure hydrocephalus (iNPH) is the CSF removal test. For elderly patients, however, a less invasive diagnostic method is required. On MRI, high-convexity tightness was reported to be an important finding for the diagnosis of iNPH. On SPECT, patients with iNPH often show hyperperfusion of the high-convexity area. The authors tested 2 hypotheses regarding the SPECT finding: 1) it is relative hyperperfusion reflecting the increased gray matter density of the convexity, and 2) it is useful for the diagnosis of iNPH. The authors termed the SPECT finding the convexity apparent hyperperfusion (CAPPAH) sign. METHODS: Two clinical studies were conducted. In study 1, SPECT was performed for 20 patients suspected of having iNPH, and regional cerebral blood flow (rCBF) of the high-convexity area was examined using quantitative analysis. Clinical differences between patients with the CAPPAH sign (CAP) and those without it (NCAP) were also compared. In study 2, the CAPPAH sign was retrospectively assessed in 30 patients with iNPH and 19 healthy controls using SPECT images and 3D stereotactic surface projection. RESULTS: In study 1, rCBF of the high-convexity area of the CAP group was calculated as 35.2–43.7 ml/min/100 g, which is not higher than normal values of rCBF determined by SPECT. The NCAP group showed lower cognitive function and weaker responses to the removal of CSF than the CAP group. In study 2, the CAPPAH sign was positive only in patients with iNPH (24/30) and not in controls (sensitivity 80%, specificity 100%). The coincidence rate between tight high convexity on MRI and the CAPPAH sign was very high (28/30). CONCLUSIONS: Patients with iNPH showed hyperperfusion of the high-convexity area on SPECT; however, the presence of the CAPPAH sign did not indicate real hyperperfusion of rCBF in the high-convexity area. The authors speculated that patients with iNPH without the CAPPAH sign, despite showing tight high convexity on MRI, might have comorbidities such as Alzheimer’s disease.
    Mar. 2018, Journal of neurosurgery, 130(2) (2), 398 - 405, English, International magazine
    [Refereed]
    Scientific journal

  • Akinori Nakamura, Naoki Kaneko, Victor L Villemagne, Takashi Kato, James Doecke, Vincent Doré, Chris Fowler, Qiao-Xin Li, Ralph Martins, Christopher Rowe, Taisuke Tomita, Katsumi Matsuzaki, Kenji Ishii, Kazunari Ishii, Yutaka Arahata, Shinichi Iwamoto, Kengo Ito, Koichi Tanaka, Colin L Masters, Katsuhiko Yanagisawa
    To facilitate clinical trials of disease-modifying therapies for Alzheimer's disease, which are expected to be most efficacious at the earliest and mildest stages of the disease, supportive biomarker information is necessary. The only validated methods for identifying amyloid-β deposition in the brain-the earliest pathological signature of Alzheimer's disease-are amyloid-β positron-emission tomography (PET) imaging or measurement of amyloid-β in cerebrospinal fluid. Therefore, a minimally invasive, cost-effective blood-based biomarker is desirable. Despite much effort, to our knowledge, no study has validated the clinical utility of blood-based amyloid-β markers. Here we demonstrate the measurement of high-performance plasma amyloid-β biomarkers by immunoprecipitation coupled with mass spectrometry. The ability of amyloid-β precursor protein (APP)669-711/amyloid-β (Aβ)1-42 and Aβ1-40/Aβ1-42 ratios, and their composites, to predict individual brain amyloid-β-positive or -negative status was determined by amyloid-β-PET imaging and tested using two independent data sets: a discovery data set (Japan, n = 121) and a validation data set (Australia, n = 252 including 111 individuals diagnosed using 11C-labelled Pittsburgh compound-B (PIB)-PET and 141 using other ligands). Both data sets included cognitively normal individuals, individuals with mild cognitive impairment and individuals with Alzheimer's disease. All test biomarkers showed high performance when predicting brain amyloid-β burden. In particular, the composite biomarker showed very high areas under the receiver operating characteristic curves (AUCs) in both data sets (discovery, 96.7%, n = 121 and validation, 94.1%, n = 111) with an accuracy approximately equal to 90% when using PIB-PET as a standard of truth. Furthermore, test biomarkers were correlated with amyloid-β-PET burden and levels of Aβ1-42 in cerebrospinal fluid. These results demonstrate the potential clinical utility of plasma biomarkers in predicting brain amyloid-β burden at an individual level. These plasma biomarkers also have cost-benefit and scalability advantages over current techniques, potentially enabling broader clinical access and efficient population screening.
    Feb. 2018, Nature, 554(7691) (7691), 249 - 254, English, International magazine
    [Refereed]
    Scientific journal

  • Kazunari Ishii
    Feb. 2018, Nature, English
    [Refereed]
    Scientific journal

  • 神経核内封入体病の1例
    沼本勲男, 松木充, 福井秀行, 若林雄一, 日高正二郎, 渡口真史, 藤谷哲也, 山川美帆, 兵頭朋子, 山田穣, 任誠雲, 甲斐田勇人, 柳生行伸, 柏木伸夫, 細川知紗, 小塚健倫, 鶴崎正勝, 今岡いずみ, 細野眞, 石井一成, 村上卓道
    (公社)日本医学放射線学会, Feb. 2018, Japanese Journal of Radiology, 36(Suppl.) (Suppl.), 27 - 27, Japanese

  • 孤立性内臓動脈解離のCT所見
    福井秀行, 松木充, 任誠雲, 甲斐田勇人, 柳生行伸, 小塚健倫, 細川知紗, 熊野正士, 柏木伸夫, 鶴崎正勝, 今岡いずみ, 細野眞, 石井一成, 村上卓道
    (公社)日本医学放射線学会, Feb. 2018, Japanese Journal of Radiology, 36(Suppl.) (Suppl.), 34 - 34, Japanese

  • Hayato Kaida, Koichi Azuma, Uhi Toh, Akihiko Kawahara, Eiji Sadashima, Satoshi Hattori, Jun Akiba, Nobuhiro Tahara, Axel Rominger, Kazunari Ishii, Takamichi Murakami, Masatoshi Ishibashi
    P.Ziti and Co, Jan. 2018, Hellenic Journal of Nuclear Medicine, 21(1) (1), 35 - 42, English
    [Refereed]
    Scientific journal

  • Janusch Blautzik, Sebastian Kotz, Matthias Brendel, Julia Sauerbeck, Franziska Vettermann, Yaroslav Winter, Peter Bartenstein, Kazunari Ishii, Axel Rominger
    Body weight loss in late-life is known to occur at a very early stage of Alzheimer's disease (AD). Apolipoprotein E4 (ApoE4) represents a major genetic risk factor for AD and is linked to an increased cortical amyloid-β (Aβ) accumulation. Since the relationship between body weight, ApoE4, and AD pathology is poorly investigated, we aimed to evaluate whether ApoE4 allelic status modifies the association of body mass index (BMI) with markers of AD pathology. A total of 368 Aβ-positive cognitively healthy or mild cognitive impaired subjects had undergone [18F]-AV45-PET, [18F]-FDG-PET, and T1w-MRI examinations. Composite cortical [18F]-AV45 uptake and [18F]-FDG uptake in posterior cingulate cortex were calculated as surrogates of cortical Aβ load and glucose metabolism, respectively. Multiple linear regressions were performed to assess the relationships between these PET biomarkers with BMI, present cognitive performance, and cognitive changes over time. Multivariate analysis of covariance was conducted to test for statistical differences between ApoE4/BMI categories on the PET markers and cognitive scores. In carriers of the ApoE4 allele only, BMI was inversely associated with cortical amlyoid load (β= -0.193, p < 0.005) and recent cognitive decline (β= -0.209, p < 0.05), and positively associated with cortical glucose metabolism in an AD-vulnerable region (β= 0.145, p < 0.05). ApoE4/BMI category analyses demonstrated lower Aβ load, higher posterior cingulate glucose metabolism, improved cognitive performance, and lower progression of cognitive decline in obese ApoE4 carriers. The effect of ApoE4 in promoting the accumulation of cortical amyoid, which may itself be a driver for weight loss, may be moderated by altering leptin signaling in the hypothalamus.
    2018, Journal of Alzheimer's disease : JAD, 65(3) (3), 781 - 791, English, International magazine
    [Refereed]
    Scientific journal

  • Hayato Kaida, Kazunari Ishii, Soichiro Hanada, Yuji Tohda, Takamichi Murakami
    Jan. 2018, Clinical nuclear medicine, 43(1) (1), 25 - 27, English, International magazine
    [Refereed]
    Scientific journal

  • Matthias Brendel, Julia Sauerbeck, Sonja Greven, Sebastian Kotz, Franziska Scheiwein, Janusch Blautzik, Andreas Delker, Oliver Pogarell, Kazunari Ishii, Peter Bartenstein, Axel Rominger
    Late-life depression, even when of subsyndromal severity, has shown strong associations with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Preclinical studies have suggested that serotonin selective reuptake inhibitors (SSRIs) can attenuate amyloidogenesis. Therefore, we aimed to investigate the effect of SSRI medication on amyloidosis and grey matter volume in subsyndromal depressed subjects with MCI and AD during an interval of two years. 256 cognitively affected subjects (225 MCI/ 31 AD) undergoing [18F]-AV45-PET and MRI at baseline and 2-year follow-up were selected from the ADNI database. Subjects with a positive depression item (DEP(+); n = 73) in the Neuropsychiatric Inventory Questionnaire were subdivided to those receiving SSRI medication (SSRI(+); n = 24) and those without SSRI treatment (SSRI(-); n = 49). Longitudinal cognition (Δ-ADAS), amyloid deposition rate (standardized uptake value, using white matter as reference region (SUVRWM), and changes in grey matter volume were compared using common covariates. Analyses were performed separately in all subjects and in the subgroup of amyloid-positive subjects. Cognitive performance in DEP(+)/SSRI(+) subjects (Δ-ADAS: -5.0%) showed less deterioration with 2-year follow-up when compared to DEP(+)/SSRI(-) subjects (Δ-ADAS: +18.6%, p < 0.05), independent of amyloid SUVRWM at baseline. With SSRI treatment, the progression of grey matter atrophy was reduced (-0.9% versus -2.7%, p < 0.05), notably in fronto-temporal cortex. A slight trend towards lower amyloid deposition rate was observed in DEP(+)/SSRI(+) subjects versus DEP(+)/SSRI(-). Despite the lack of effect to amyloid PET, SSRI medication distinctly rescued the declining cognitive performance in cognitively affected patients with depressive symptoms, and likewise attenuated grey matter atrophy.
    2018, Journal of Alzheimer's disease : JAD, 65(3) (3), 793 - 806, English, International magazine
    [Refereed]
    Scientific journal

  • Masahiko Takaya, Masahiko Atsumi, Kazunari Ishii, Osamu Shirakawa
    Nov. 2017, PSYCHOGERIATRICS, 17(6) (6), 495 - 497, English, International magazine
    [Refereed]
    Scientific journal

  • Hideyuki Fukui, Nobuo Kashiwagi, Takamichi Murakami, Yoshiyuki Watanabe, Tomoko Hyodo, Kazunari Ishii, Miho Yamakawa, Hirito Takahashi, Noriyuki Tomiyama
    OBJECTIVES: The infraorbital canal (IOC), which runs in the roof of the maxillary sinus, is a useful anatomical landmark for the infraorbital nerve (ION) on computed tomography (CT) images. Enlargement of the IOC on CT images is thought to be a pathological state that usually affects the ION. However, we have frequently observed enlargement of the IOC in patients with a history of radical surgery of the maxillary sinus: so-called Caldwell-Luc (CL) surgery. In this study, the size of the IOC of the maxillary sinus was compared between patients with a history of CL surgery (post-CL IOCs) and those with no history of CL surgery (control IOCs). METHODS: A total of 347 consecutive patients who underwent facial CT from January 2014 to October 2014 for various indications were evaluated. After excluding groove-type IOCs and IOCs with pathological lesions that could affect their diameters, 47 post-CL IOCs in 26 patients were finally compared with 504 control IOCs in 252 patients. To evaluate IOC size, the short-axis diameter of the IOC was measured on a reconstructed coronal image at the level of the posterior pole of the eyeball. RESULTS: The short-axis diameters of the post-CL IOCs and control IOCs were 3.0 ± 0.6 and 1.4 ± 0.3 mm, respectively (p < 0.005). CONCLUSIONS: The short-axis diameters of post-CL IOCs are significantly enlarged (approximately double the diameter) compared to those of control IOCs.
    Sep. 2017, Japanese journal of radiology, 35(9) (9), 532 - 538, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Kazunari Ishii
    Jun. 2017, Acta Neurochirurgica, English
    [Refereed]
    Scientific journal

  • Tomohiko Yamane, Kenji Ishii, Muneyuki Sakata, Yasuhiko Ikari, Tomoyuki Nishio, Kazunari Ishii, Takashi Kato, Kengo Ito, Michio Senda
    May 2017, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 44(5) (5), 850 - 857, English, International magazine
    [Refereed]
    Scientific journal

  • Increased Pittsburgh Compound-B Accumulation in the Subcortical White Matter of Alzheimer's Disease Brain
    Wakabayashi Y, Ishii K, Hosokawa C, Hyodo T
    May 2017, Kobe J Med Sci, 62(5) (5), 136 - 141
    [Refereed]

  • Tomohiko Yamane, Kenji Ishii, Muneyuki Sakata, Yasuhiko Ikari, Tomoyuki Nishio, Kazunari Ishii, Takashi Kato, Kengo Ito, Michio Senda
    May 2017, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 44(5) (5), 850 - 857, English
    [Refereed]
    Scientific journal

  • Increased Pittsburgh Compound-B Accumulation in the Subcortical White Matter of Alzheimer's Disease Brain.
    Yuichi Wakabayashi, Kazunari Ishii, Chisa Hosokawa, Tomoko Hyodo, Hayato Kaida, Minoru Yamada, Yukinobu Yagyu, Masakatsu Tsurusaki, Takenori Kozuka, Kazuro Sugimura, Takamichi Murakami
    Using 11C-Pittsburgh compound B (PiB)-PET and MRI volume data, we investigated whether white matter (WM) PiB uptake in Alzheimer's disease (AD) brain is larger than that of cortical PiB uptake-negative (PiB-negative) brain. Forty-five subjects who underwent both PiB-PET and MRI were included in the study (32 AD patients with cortical PiB-positive and 13 cortical amyloid -negative patients). Individual areas of gray matter (GM) and WM were segmented, then regional GM and WM standard uptake value ratio (SUVR) normalized to cerebellar GM with partial volume effects correction was calculated. Three regional SUVRs except WM in the centrum semiovale in the AD group were significantly larger than those in the PiB-negative groups. Frontal WM SUVR in the AD group vs frontal WM SUVR in the PiB-negative group was 2.57 ± 0.55 vs 1.64 ± 0.22; parietal, 2.50 ± 0.52 vs 1.74 ± 0.22; posterior cingulate, 2.84 ± 0.59 vs 1.73 ± 0.22; and WM in the centrum semiovale, 2.21 ± 0.53 vs 2.42 ± 0.36, respectively. We found that PiB uptake in AD brain is significantly larger than that in PiB-negative brain in the frontal, parietal and posterior cingulate subcortical WM, except in the centrum semiovale.
    Mar. 2017, The Kobe journal of medical sciences, 62(5) (5), E136-E141 - E141, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Silvia Morbelli, Javier Arbizu, Jan Booij, Ming-Kai Chen, Gael Chetelat, Donna J Cross, Mehdi Djekidel, Alexander Drzezga, Ozgul Ekmekcioglu, Valentina Garibotto, Swen Hesse, Kazunari Ishii, Lida Jafari, Adriaan A Lammertsma, Ian Law, Dana Mathews, Satoshi Minoshima, Karina Mosci, Marco Pagani, Sabina Pappata, Daniel Hillel Silverman, Alberto Signore, Elsmarieke Van De Giessen, Victor Villemagne, Henryk Barthel
    Mar. 2017, European journal of nuclear medicine and molecular imaging, 44(3) (3), 353 - 357, English, International magazine
    [Refereed]

  • Silvia Morbelli, Javier Arbizu, Jan Booij, Ming-Kai Chen, Gael Chetelat, Donna J Cross, Mehdi Djekidel, Alexander Drzezga, Ozgul Ekmekcioglu, Valentina Garibotto, Swen Hesse, Kazunari Ishii, Lida Jafari, Adriaan A Lammertsma, Ian Law, Dana Mathews, Satoshi Minoshima, Karina Mosci, Marco Pagani, Sabina Pappata, Daniel Hillel Silverman, Alberto Signore, Elsmarieke Van De Giessen, Victor Villemagne, Henryk Barthel
    Mar. 2017, European journal of nuclear medicine and molecular imaging, 44(3) (3), 559 - 560, English, International magazine
    [Refereed]
    Scientific journal

  • Silvia Morbelli, Javier Arbizu, Jan Booij, Ming-Kai Chen, Gael Chetelat, Donna J. Cross, Mehdi Djekidel, Alexander Drzezga, Ozgul Ekmekcioglu, Valentina Garibotto, Swen Hesse, Kazunari Ishii, Lida Jafari Saraf, Adriaan A. Lammertsma, Ian Law, Dana Mathews, Satoshi Minoshima, Karina Mosci, Marco Pagani, Sabina Pappata, Daniel Hillel Silverman, Alberto Signore, Elsmarieke Van de Giessen, Victor Villemagne, Henryk Barthel
    Mar. 2017, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 44(3) (3), 353 - 357, English
    [Refereed]

  • Kazunari Ishii
    Wiley, Feb. 2017, Acta Neurologica Scandinavica, 135(2) (2), 189 - 196, English
    [Refereed]
    Scientific journal

  • H. Takahashi, K. Ishii, N. Kashiwagi, Y. Watanabe, H. Tanaka, T. Murakami, N. Tomiyama
    Feb. 2017, CLINICAL RADIOLOGY, 72(2) (2), 108 - 115, English
    [Refereed]
    Scientific journal

  • Hiroaki Kazui, Ryuichi Takahashi, Yuki Yamamoto, Kenji Yoshiyama, Hideki Kanemoto, Yukiko Suzuki, Shunsuke Sato, Shingo Azuma, Takashi Suehiro, Eku Shimosegawa, Kazunari Ishii, Toshihisa Tanaka
    2017, Journal of Alzheimer's disease : JAD, 55(4) (4), 1403 - 1416, English, International magazine
    [Refereed]
    Scientific journal

  • Regional differences in amyloid deposition between 11C-PiB PET positive patients with and without elevated striatal amyloid uptake.
    Scheiwein FT, Ishii K, Hosokawa C, Kaida H, Hyodo T, Hanaoka K, Brendel M, Bartenstein B, Rominger A, Murakami
    2017, J Alzheimers Dis Parkinsonism, 7, 317, English
    [Refereed]
    Scientific journal

  • Ryuichi Takahashi, Kazunari Ishii, Kazumasa Yokoyama
    2017, CURRENT ALZHEIMER RESEARCH, 14(2) (2), 161 - 168, English
    [Refereed]
    Scientific journal

  • 石井一成
    (株)ワールドプランニング, Jan. 2017, 老年精神医学雑誌, 28(増刊I) (増刊I), 100 - 105, Japanese

  • Kazunari Ishii
    OBJECTIVE Idiopathic normal pressure hydrocephalus (iNPH) is treated with cerebrospinal fluid shunting, and implantation of a ventriculoperitoneal shunt (VPS) is the current standard treatment. The objective of this study was to compare the efficacy and safety of VPSs and lumboperitoneal shunts (LPSs) for patients with iNPH. METHODS The authors conducted a prospective multicenter study of LPS use for patients with iNPH. Eighty-three patients with iNPH (age 60 to 85 years) who presented with ventriculomegaly and high-convexity and medial subarachnoid space tightness on MR images were recruited from 20 neurological or neurosurgical centers in Japan between March 1, 2010, and October 19, 2011. The primary outcome was the modified Rankin Scale (mRS) score 1 year after surgery, and the secondary outcome included scores on the iNPH grading scale (iNPHGS). A previously conducted VPS cohort study with the same inclusion criteria and primary and secondary end points was used as a historical control. RESULTS The proportion of patients who achieved a favorable outcome (i.e., improvement of at least 1 point in their mRS score) was 63% (95% CI 51%–73%) and was comparable to values reported with VPS implantation (69%, 95% CI 59%–78%). Using the iNPHGS, the 1-year improvement rate was 75% (95% CI 64%–84%) and was comparable to the rate found in the VPS study (77%, 95% CI 68%–84%). The proportion of patients experiencing serious adverse events (SAEs) and non-SAEs did not differ significantly between the groups at 1 year after surgery (SAEs: 19 [22%] of 87 LPS patients vs 15 [15%] of 100 VPS patients, p = 0.226; non-SAEs: 24 [27.6%] LPS patients vs 20 [20%] VPS patients, p = 0.223). However, shunt revisions were more common in LPS-treated patients than in VPS-treated patients (6 [7%] vs 1 [1%]). CONCLUSIONS The efficacy and safety rates for LPSs with programmable valves are comparable to those for VPSs for the treatment of patients with iNPH. Despite the relatively high shunt failure rate, an LPS can be the treatment of choice because of its minimal invasiveness and avoidance of brain injury.
    Dec. 2016, Journal of Neurosurgery
    [Refereed]
    Scientific journal

  • Kenta Sakaguchi, Makoto Hosono, Tomomi Imamura, Naomi Takahara, Misa Hayashi, Yuko Yakushiji, Kazunari Ishii, Tatsuro Uto, Takamichi Murakami
    BACKGROUND: Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) is now a routine procedure for the management of cancer patients. Intravenous administration of FDG is sometimes halted due to troubles. In such cases, estimations of the FDG dosage injected prior to halting administration may be helpful. We have established a method of estimating the activity of FDG to patients on the basis of the dose equivalent rate on the surface of the right temporal region of the head. The correlation of actual administered dosage with independent variables, such as the dose equivalent rate on the right temporal region of the head, age, sex, and body weight, was analyzed using multiple regression analysis to obtain linear, quadratic, and cubic regression equations. RESULTS: When entering independent variables, the cubic regression equation could be used to estimate an administered dosage with an accuracy of ±10 % for 62 % of all patients and ±20 % for 90 % of all patients. CONCLUSIONS: We conclude that this method is useful for estimating the administered dosage from the dose equivalent rate on the temporal region of the head.
    Dec. 2016, EJNMMI physics, 3(1) (1), 28 - 28, English, International magazine
    [Refereed]
    Scientific journal

  • 治る認知症を見逃さない
    石井一成
    (株)医学出版, Dec. 2016, レジデント, 9(12) (12), 102 - 109, Japanese

  • Diagnostic imaging for idiopathic normal pressure hydrocephalus
    石井一成
    (株)ワールドプランニング, Nov. 2016, 老年精神医学雑誌, 27(11) (11), 1171 - 1175, Japanese

  • Hayato Kaida, Koichi Azuma, Akihiko Kawahara, Masafumi Yasunaga, Yuhei Kitasato, Satoshi Hattori, Tomoki Taira, Hiroki Ureshino, Masayoshi Kage, Kazunari Ishii, Takamichi Murakami, Masatoshi Ishibashi
    Oct. 2016, EUROPEAN JOURNAL OF RADIOLOGY, 85(10) (10), 1804 - 1810, English
    [Refereed]
    Scientific journal

  • The usefulness of brain perfusion SPECT for differential diagnosis of dementia
    石井一成
    (株)ワールドプランニング, Sep. 2016, 老年精神医学雑誌, 27(9) (9), 934 - 940, Japanese

  • Kazunari Ishii
    OBJECTIVEThe study aim was to assess the influence of presurgical clinical symptom severity and disease duration on outcomes of shunt surgery in patients with idiopathic normal-pressure hydrocephalus (iNPH). The authors also evaluated the cerebrospinal fluid tap test as a predictor of improvements following shunt surgery.METHODSEighty-three patients (45 men and 38 women, mean age 76.4 years) underwent lumboperitoneal shunt surgery, and outcomes were evaluated until 12 months following surgery. Risks for poor quality of life (Score 3 or 4 on the modified Rankin Scale [mRS]) and severe gait disturbance were evaluated at 3 and 12 months following shunt surgery, and the tap test was also conducted. Age-adjusted and multivariate relative risks were calculated using Cox proportional-hazards regression.RESULTSOf 83 patients with iNPH, 45 (54%) improved by 1 point on the mRS and 6 patients (7%) improved by ≥ 2 points at 3 months following surgery. At 12 months after surgery, 39 patients (47%) improved by 1 point on the mRS and 13 patients (16%) improved by ≥ 2 points. On the gait domain of the iNPH grading scale (iNPHGS), 36 patients (43%) improved by 1 point and 13 patients (16%) improved by ≥ 2 points at 3 months following surgery. Additionally, 32 patients (38%) improved by 1 point and 14 patients (17%) by ≥ 2 points at 12 months following surgery. In contrast, 3 patients (4%) and 2 patients (2%) had worse symptoms according to the mRS or the gait domain of the iNPHGS, respectively, at 3 months following surgery, and 5 patients (6%) and 3 patients (4%) had worse mRS scores and gait domain scores, respectively, at 12 months after surgery. Patients with severe preoperative mRS scores had a 4.7 times higher multivariate relative risk (RR) for severe mRS scores at 12 months following surgery. Moreover, patients with severe gait disturbance prior to shunt surgery had a 46.5 times greater multivariate RR for severe gait disturbance at the 12-month follow-up. Patients without improved gait following the tap test had multivariate RRs for unimproved gait disturbance of 7.54 and 11.2 at 3 and 12 months following surgery, respectively. Disease duration from onset to shunt surgery was not significantly associated with postoperative symptom severity or unimproved symptoms.CONCLUSIONSPatients with iNPH should receive treatment before their symptoms become severe in order to achieve an improved quality of life. However, the progression of symptoms varies between patients so specific timeframes are not meaningful. The authors also found that tap test scores accurately predicted shunt efficacy. Therefore, indications for shunt surgery should be carefully assessed in each patient with iNPH, considering the relative risks and benefits for that person, including healthy life expectancy.
    Jul. 2016, Journal of Neurosurgery
    [Refereed]
    Scientific journal

  • Hiroshi Watanabe, Kazunari Ishii, Makoto Hosono, Etsuko Imabayashi, Koichiro Abe, Masayuki Inubushi, Kazuko Ohno, Yasuhiro Magata, Kinya Ono, Kei Kikuchi, Kei Wagatsuma, Tadashi Takase, Kyoko Saito, Yasuyuki Takahashi
    Jul. 2016, ANNALS OF NUCLEAR MEDICINE, 30(6) (6), 435 - 444, English
    [Refereed]
    Scientific journal

  • Masafumi Toguchi, Mitsuru Matsuki, Isao Numoto, Masakatsu Tsurusaki, Izumi Imaoka, Kazunari Ishii, Rikiya Yamashita, Yuki Inada, Shuichi Monzawa, Hisato Kobayashi, Takamichi Murakami
    Jun. 2016, JAPANESE JOURNAL OF RADIOLOGY, 34(6) (6), 400 - 408, English
    [Refereed]

  • TOPICS from ANM：レビー小体型認知症における局所ブドウ糖代謝低下はアミロイド沈着に依存しない
    石井一成, 細川知紗, 兵頭朋子, 坂口健太, 宇佐美公男, 島元健次, 山添 穰, 村上卓道
    Jun. 2016, 臨床核医学, 49(6) (6), 89 - 90
    [Refereed]

  • Pretherapeutic FDG heterogeneity in tumors can predict local control in oropharyngeal cancer patients undergoing intensity-modulated radiation therapy
    Hanaoka Kohei, Hosono Makoto, Tatebe Hitoshi, Ishikawa Kazuki, Monzen Hajime, Ishii Kazunari, Nishimura Yasumasa
    May 2016, JOURNAL OF NUCLEAR MEDICINE, 57
    [Refereed]

  • Masahiko Takaya, Masahiko Atsumi, Tomoyuki Hirose, Kazunari Ishii, Osamu Shirakawa
    May 2016, PSYCHOGERIATRICS, 16(3) (3), 216 - 221, English
    [Refereed]
    Scientific journal

  • Kenichi Ota, Naoya Oishi, Kengo Ito, Hidenao Fukuyama
    BACKGROUND: Prediction of progression to Alzheimer's disease (AD) in amnestic mild cognitive impairment (MCI) is challenging because of its heterogeneity. OBJECTIVE: To evaluate a stratification method on different cohorts and to investigate whether stratification in amnestic MCI could improve prediction accuracy. METHODS: We identified 80 and 79 patients with amnestic MCI from different cohorts, respectively. They underwent baseline magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) scans. We performed hierarchical clustering with three imaging biomarkers: Brain volume on MRI, left hippocampus grey matter loss on MRI, and left inferior temporal gyrus glucose hypometabolism on FDG-PET. Regions-of-interest for biomarkers were defined by the Automated Anatomical Labeling atlas. We performed voxel-wise statistical parametric mapping to explore differences between clusters in patterns of grey matter loss and glucose hypometabolism. We compared time to progression using an interval-censored parametric model. We evaluated predictive performance using logistic regression. RESULTS: Similar clusters were found in different cohorts. MCI1 had the healthiest biomarker profile of cognitive performance and imaging biomarkers. MCI2 had cognitive performance and MRI measures intermediate between those of nonconverters and converters. MCI3 showed the severest reduction in brain volume and left hippocampal atrophy. MCI4 showed remarkable glucose hypometabolism in the left inferior temporal gyrus, and also demonstrated significant decreases in most cognitive scores, including non-memory functions. MCI4 showed the highest risk for progression. The prediction of progression of MCI2 especially benefited from the stratification. CONCLUSION: Stratification with imaging biomarkers in amnestic MCI can be a good approach for improving predictive performance.
    Apr. 2016, Journal of Alzheimer's disease : JAD, 52(4) (4), 1385 - 401, English, International magazine
    Scientific journal

  • Ryuji Sakakibara, Yoshitaka Uchida, Kazunari Ishii, Masaaki Hashimoto, Masaaki Ishikawa, Hiromitsu Kazui, Tatsuya Yamamoto, Tomoyuki Uchiyama, Fuyuki Tateno, Masahiko Kishi, Yohei Tsuyusaki, Yosuke Aiba, Hiromi Tateno, Takeki Nagao, Hitoshi Terada, Tsutomu Inaoka
    Feb. 2016, INTERNATIONAL UROLOGY AND NEPHROLOGY, 48(2) (2), 169 - 174, English
    [Refereed]
    Scientific journal

  • アルツハイマー病の診断にどのような画像検査を推奨するか？
    石井一成
    2016, 画像診断ガイドライン2016年度版, 95 - 97
    [Refereed]

  • 特発性正常圧水頭症にはどのような画像検査が有用か？
    石井一成
    2016, 画像診断ガイドライン2016年度版, 98 - 99
    [Refereed]

  • Kenichi Ota, Naoya Oishi, Kengo Ito, Hidenao Fukuyama
    BACKGROUND: The choice of biomarkers for early detection of Alzheimer's disease (AD) is important for improving the accuracy of imaging-based prediction of conversion from mild cognitive impairment (MCI) to AD. The primary goal of this study was to assess the effects of imaging modalities and brain atlases on prediction. We also investigated the influence of support vector machine recursive feature elimination (SVM-RFE) on predictive performance. METHODS: Eighty individuals with amnestic MCI [40 developed AD within 3 years] underwent structural magnetic resonance imaging (MRI) and (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans at baseline. Using Automated Anatomical Labeling (AAL) and LONI Probabilistic Brain Atlas (LPBA40), we extracted features representing gray matter density and relative cerebral metabolic rate for glucose in each region of interest from the baseline MRI and FDG-PET data, respectively. We used linear SVM ensemble with bagging and computed the area under the receiver operating characteristic curve (AUC) as a measure of classification performance. We performed multiple SVM-RFE to compute feature ranking. We performed analysis of variance on the mean AUCs for eight feature sets. RESULTS: The interactions between atlas and modality choices were significant. The main effect of SVM-RFE was significant, but the interactions with the other factors were not significant. COMPARISON WITH EXISTING METHOD: Multimodal features were found to be better than unimodal features to predict AD. FDG-PET was found to be better than MRI. CONCLUSIONS: Imaging modalities and brain atlases interact with each other and affect prediction. SVM-RFE can improve the predictive accuracy when using atlas-based features.
    Dec. 2015, Journal of neuroscience methods, 256, 168 - 83, English, International magazine
    Scientific journal

  • Chisa Hosokawa, Kazunari Ishii, Yuichi Kimura, Tomoko Hyodo, Makoto Hosono, Kenta Sakaguchi, Kimio Usami, Kenji Shimamoto, Yuzuru Yamazoe, Takamichi Murakami
    Dec. 2015, JOURNAL OF NUCLEAR MEDICINE, 56(12) (12), 1910 - 1915, English
    [Refereed]
    Scientific journal

  • SungWoon Im, Ryuichiro Ashikaga, Yukinobu Yagyu, Tetsuya Wakayama, Mitsuharu Miyoshi, Tomoko Hyodo, Izumi Imaoka, Seishi Kumano, Kazunari Ishii, Takamichi Murakami
    Nov. 2015, EUROPEAN RADIOLOGY, 25(11) (11), 3175 - 3186, English
    [Refereed]
    Scientific journal

  • Hiroaki Kazui, Masakazu Miyajima, Etsuro Mori, Masatsune Ishikawa
    BACKGROUND: Lumboperitoneal shunt surgery has the potential to alleviate symptoms of normal pressure hydrocephalus but the benefits of such surgery have not been tested in a randomised trial. The aim of this trial was to determine the safety and efficacy of the lumboperitoneal shunt surgery for this disorder. METHODS: For the open-label randomised SINPHONI-2 trial, eligible participants (60-85 years of age) with idiopathic normal pressure hydrocephalus, with ventriculomegaly, and tightness of the high-convexity and medial subarachnoid spaces on MRI, were recruited from 20 neurological and neurosurgical centres in Japan. Enrolled participants were randomly assigned in a 1:1 ratio according to a random code generated by the trial statistician, with a permuted block design (using a block size of 4 or 6) within each centre, to receive lumboperitoneal shunt surgery within 1 month after randomisation, or to surgery postponed for 3 months. Patients and assessors were not masked to treatment assignment. The primary endpoint was favourable outcome, defined as an improvement of one point or more on the modified Rankin scale (mRS) at 3 months after randomisation, analysed by intention to treat, and the main secondary endpoint was the same outcome 12 months after surgery, analysed per protocol. This trial is registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR), number UMIN000002730. FINDINGS: Between March 1, 2010, and Oct 19, 2011, 93 patients with idiopathic normal pressure hydrocephalus were enrolled and randomly assigned to the immediate treatment group (n=49) or the postponed treatment group (n=44). More patients in the immediate treatment group than in the postponed treatment group had an improvement of one point or more on the mRS at 3 months: 32 (65%) of 49 in the immediate group vs 2 (5%) of 44 in the postponed group (difference 61% [95% CI 42-68]; p<0·0001). The number of patients who had an improvement of one point or more on the mRS at 12 months after surgery was similar between the two groups: 30 (67%) of 45 patients in the immediate group vs 22 (58%) of 38 in the postponed group (difference 9% [95% CI -14 to 31]; p=0·496). The proportions of patients with serious adverse events did not differ significantly between the groups during the 3 months post-randomisation (7 [15%] of 46 in the immediate group vs 1 [2%] of 42 in the postponed group; p=0·060). During the 12 months after surgery, 19 (22%) of 87 patients had serious adverse events, the most common of which was cerebral infarction (six patients [7%]). INTERPRETATION: Our results suggest that lumboperitoneal shunt surgery might be beneficial for patients with idiopathic normal pressure hydrocephalus and, if these findings are confirmed in larger studies, could be a first-line treatment option for this disease. FUNDING: Johnson & Johnson and Nihon Medi-Physics.
    Jun. 2015, The Lancet. Neurology, 14(6) (6), 585 - 94, English, International magazine
    Scientific journal

  • Kazunari Ishii
    Lancet Publishing Group, Jun. 2015, The Lancet Neurology, 14(6) (6), 585 - 94, English, International magazine
    [Refereed]
    Scientific journal

  • Radiation exposure of nursing staff in PET practices in correlation to performance status of patients
    Makoto Hosono, Naomi Takahara, Yuuko Yakushiji, Kenta Sakaguchi, Kazunari Ishii
    May 2015, JOURNAL OF NUCLEAR MEDICINE, 56(3) (3), English
    [Refereed]

  • Kohei Hanaoka, Makoto Hosono, Yoichi Tatsumi, Kazunari Ishii, Sung-Woon Im, Norio Tsuchiya, Kenta Sakaguchi, Itaru Matsumura
    Mar. 2015, EJNMMI RESEARCH, 5, 10, English
    [Refereed]
    Scientific journal

  • Masahiro Okada, Takamichi Murakami, Norihisa Yada, Kazushi Numata, Minori Onoda, Tomoko Hyodo, Tatsuo Inoue, Kazunari Ishii, Masatoshi Kudo
    Feb. 2015, JOURNAL OF MAGNETIC RESONANCE IMAGING, 41(2) (2), 329 - 338, English
    [Refereed]
    Scientific journal

  • Chisa Hosokawa, Kazunari Ishii, Tomoko Hyodo, Kenta Sakaguchi, Kimio Usami, Kenji Shimamoto, Yuzuru Yamazoe, Makoto Hosono, Kazushi Hanada, Masami Ueda, Kazuma Saigo, Takamichi Murakami
    Feb. 2015, ANNALS OF NUCLEAR MEDICINE, 29(2) (2), 164 - 169, English
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Chisa Hosokawa, Tomoko Hyodo, Kenta Sakaguchi, Kimio Usami, Kenji Shimamoto, Makoto Hosono, Yuzuru Yamazoe, Takamichi Murakami
    Jan. 2015, ANNALS OF NUCLEAR MEDICINE, 29(1) (1), 78 - 83, English
    [Refereed]
    Scientific journal

  • Kengo Ito, Hidenao Fukuyama, Michio Senda, Kazunari Ishii, Kiyoshi Maeda, Yasuji Yamamoto, Yasuomi Ouchi, Kenji Ishii, Ayumu Okumura, Ken Fujiwara, Takashi Kato, Yutaka Arahata, Yukihiko Washimi, Yoshio Mitsuyama, Kenichi Meguro, Mitsuru Ikeda
    2015, JOURNAL OF ALZHEIMERS DISEASE, 45(2) (2), 543 - 552, English
    [Refereed]
    Scientific journal

  • Sakai K, Oda H, Terashima A, Ishii K, Maeda K
    2015, Case reports in psychiatry, 2015, 968598
    [Refereed]

  • Ryota Itoh, Issaku Murakami, Bin Chou, Kazunari Ishii, Toshinori Soejima, Toshihiko Suzuki, Kenji Hiromatsu
    Sep. 2014, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 452(3) (3), 689 - 694, English
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Kengo Ito, Atsushi Nakanishi, Shin Kitamura, Akira Terashima
    Jul. 2014, JAPANESE JOURNAL OF RADIOLOGY, 32(7) (7), 383 - 390, English
    [Refereed]
    Scientific journal

  • Heterogeneity of intratumoral In-111-Zevalin and FDG distribution in association with therapeutic response in radioimmunotherapy for B-cell lymphoma
    Hosono Makoto, Hanaoka Kohei, Ishii Kazunari, Sakaguchi Kenta, Im Sung-Woon, Tsuchiya Norio, Komeya Yoshihiro, Tatsumi Yoichi, Matsumura Itaru
    May 2014, JOURNAL OF NUCLEAR MEDICINE, 55
    [Refereed]

  • Comparison between SUV and BP images acquired using 11C-PIB PET: Questionable PIB accumulation in SUV images
    Hosokawa Chisa, Ishii Kazunari, Kimura Yuichi, Sakaguchi Kenta, Hosono Makoto, Murakami Takamichi
    May 2014, JOURNAL OF NUCLEAR MEDICINE, 55
    [Refereed]

  • Tomonori Kanda, Kazunari Ishii, Hiroki Kawaguchi, Kazuhiro Kitajima, Daisuke Takenaka
    Mar. 2014, RADIOLOGY, 270(3) (3), 834 - 841, English
    [Refereed]
    Scientific journal

  • 自然消退をきたした頸部デスモイドの1例
    松久保 祐子, 西川 正則, 柏木 伸夫, 柳生 行伸, 小塚 健倫, 熊野 正士, 今岡 いずみ, 石井 一成, 足利 竜一朗, 細野 眞, 村上 卓道, 森 一功, 佐藤 隆夫
    (公社)日本医学放射線学会, Feb. 2014, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 32 - 32, Japanese

  • Tomohiko Yamane, Y. Ikari, T. Nishio, Kazunari Ishii, Kenji Ishii, T. Kato, Kengo Ito, D. H.S. Silverman, M. Senda, T. Asada, H. Arai, M. Sugishita, T. Iwatsubo
    Feb. 2014, American Journal of Neuroradiology, 35(2) (2), 244 - 249, English
    [Refereed]
    Scientific journal

  • Kenichi Ota, Naoya Oishi, Kengo Ito, Hidenao Fukuyama
    BACKGROUND: Although previous voxel-based studies using features extracted by atlas-based parcellation produced relatively poor performances on the prediction of Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI), classification performance usually depends on features extracted from the original images by atlas-based parcellation. To establish whether classification performance differs depending on the choice of atlases, support vector machine (SVM)-based classification using different brain atlases was performed. NEW METHOD: Seventy-seven three-dimensional T1-weighted MRI data sets of subjects with amnestic MCI, including 39 subjects who developed AD (MCI-C) within three years and 38 who did not (MCI-NC), were used for voxel-based morphometry (VBM) analyses and analyzed using SVM-based pattern recognition methods combined with a feature selection method based on the SVM recursive feature elimination (RFE) method. Three brain atlases were used for the feature selections: the Automated Anatomical Labeling (AAL) Atlas, Brodmann's Areas (BA), and the LONI Probabilistic Brain Atlas (LPBA40). RESULTS: The VBM analysis showed a significant cluster of gray matter density reduction, located at the left hippocampal region, in MCI-C compared to MCI-NC. The SVM analyses with the SVM-RFE algorithm revealed that the best classification performance was achieved by LPBA40 with 37 selected features, giving an accuracy of 77.9%. The overall performance in LPBA40 was better than that of AAL and BA regardless of the number of selected features. CONCLUSIONS: These results suggest that feature selection is crucial to improve the classification performance in atlas-based analysis and that the choice of atlases is also important.
    Jan. 2014, Journal of neuroscience methods, 221, 139 - 50, English, International magazine
    Scientific journal

  • Masakatsu Tsurusaki, Masahiko Okada, Hiroyuki Kuroda, Mitsuru Matsuki, Kazunari Ishii, Takamichi Murakami
    Jan. 2014, JOURNAL OF GASTROENTEROLOGY, 49(1) (1), 46 - 56, English
    [Refereed]

  • Yoshiyuki Nishio, Mamoru Hashimoto, Kazunari Ishii, Daisuke Ito, Shunji Mugikura, Shoki Takahashi, Etsuro Mori
    Jan. 2014, NEUROPSYCHOLOGIA, 53(1) (1), 264 - 273, English
    [Refereed]
    Scientific journal

  • H. Takahashi, K. Ishii, C. Hosokawa, T. Hyodo, N. Kashiwagi, M. Matsuki, R. Ashikaga, T. Murakami
    American Society of Neuroradiology, 2014, American Journal of Neuroradiology, 39(5) (5), 906 - 911, English
    [Refereed]
    Scientific journal

  • Yoshito Fujii, Satoshi Kaneko, Samson Muuo Nzou, Matilu Mwau, Sammy M Njenga, Chihiro Tanigawa, James Kimotho, Anne Wanjiru Mwangi, Ibrahim Kiche, Sohkichi Matsumoto, Mamiko Niki, Mayuko Osada-Oka, Yoshio Ichinose, Manabu Inoue, Makoto Itoh, Hiroshi Tachibana, Kazunari Ishii, Takafumi Tsuboi, Lay Myint Yoshida, Dinesh Mondal, Rashidul Haque, Shinjiro Hamano, Mwatasa Changoma, Tomonori Hoshi, Ken-Ichi Kamo, Mohamed Karama, Masashi Miura, Kenji Hirayama
    BACKGROUND: A strategy to combat infectious diseases, including neglected tropical diseases (NTDs), will depend on the development of reliable epidemiological surveillance methods. To establish a simple and practical seroprevalence detection system, we developed a microsphere-based multiplex immunoassay system and evaluated utility using samples obtained in Kenya. METHODS: We developed a microsphere-based immuno-assay system to simultaneously measure the individual levels of plasma antibody (IgG) against 8 antigens derived from 6 pathogens: Entamoeba histolytica (C-IgL), Leishmania donovani (KRP42), Toxoplasma gondii (SAG1), Wuchereria bancrofti (SXP1), HIV (gag, gp120 and gp41), and Vibrio cholerae (cholera toxin). The assay system was validated using appropriate control samples. The assay system was applied for 3411 blood samples collected from the general population randomly selected from two health and demographic surveillance system (HDSS) cohorts in the coastal and western regions of Kenya. The immunoassay values distribution for each antigen was mathematically defined by a finite mixture model, and cut-off values were optimized. FINDINGS: Sensitivities and specificities for each antigen ranged between 71 and 100%. Seroprevalences for each pathogen from the Kwale and Mbita HDSS sites (respectively) were as follows: HIV, 3.0% and 20.1%; L. donovani, 12.6% and 17.3%; E. histolytica, 12.8% and 16.6%; and T. gondii, 30.9% and 28.2%. Seroprevalences of W. bancrofti and V. cholerae showed relatively high figures, especially among children. The results might be affected by immunological cross reactions between W. bancrofti-SXP1 and other parasitic infections; and cholera toxin and the enterotoxigenic E. coli (ETEC), respectively. INTERPRETATION: A microsphere-based multi-serological assay system can provide an opportunity to comprehensively grasp epidemiological features for NTDs. By adding pathogens and antigens of interest, optimized made-to-order high-quality programs can be established to utilize limited resources to effectively control NTDs in Africa.
    2014, PLoS neglected tropical diseases, 8(7) (7), e3040, English, International magazine
    [Refereed]

  • Takahashi H, Okada M, Kagawa Y, Hyodo T, Hidaka S, Kudo M, Ishii K, Tomiyama N, Murakami T
    Elsevier, Dec. 2013, Eur J Radiol., 83, 684 - 691, English
    [Refereed]
    Scientific journal

  • Kengo Ito, Etsuro Mori, Hidenao Fukuyama, Kazunari Ishii, Yukihiko Washimi, Takashi Asada, Satoru Mori, Kenichi Meguro, Shin Kitamura, Haruo Hanyu, Seigo Nakano, Hiroshi Matsuda, Yasuo Kuwabara, Kazuo Hashikawa, Toshimitsu Momose, Yoshitaka Uchida, Jun Hatazawa, Satoshi Minoshima, Kenji Kosaka, Tatsuo Yamada, Yoshiharu Yonekura
    Dec. 2013, ANNALS OF NUCLEAR MEDICINE, 27(10) (10), 898 - 906, English
    [Refereed]
    Scientific journal

  • Yuko Matsukubo, Nobuo Kashiwagi, Masanobu Uemura, Sachiyo Tatsumi, Hiroto Takahashi, Tomoko Hyodo, Noriyuki Tomiyama, Ryuichiro Ashikaga, Kazunari Ishii, Takamichi Murakami
    11, Nov. 2013, Neuroradiology, 55(11) (11), 1341 - 1344, English
    [Refereed]
    Scientific journal

  • Haruhiko Oda, Kazunari Ishii, Akira Terashima, Ken-ichi Shimada, Yumiko Yamane, Ryota Kawasaki, Shingo Ohkawa
    Nov. 2013, NEUROLOGY, 81(20) (20), 1741 - 1745, English
    [Refereed]
    Scientific journal

  • Rieko Okada, Takeshi Okuda, Naoki Nakano, Kazuhiko Nishimatsu, Hiroyuki Fukushima, Minori Onoda, Toshiho Otsuki, Kazunari Ishii, Takamichi Murakami, Amami Kato
    Jul. 2013, JOURNAL OF NEUROLINGUISTICS, 26(4) (4), 470 - 478, English
    [Refereed]
    Scientific journal

  • Ryuichi Takahashi, Kazunari Ishii, Michio Senda, Kengo Ito, Kenji Ishii, Takashi Kato, Yoko Makishi, Tomoyuki Nishio, Yasuhiko Ikari, Takeshi Iwatsubo
    Jun. 2013, ANNALS OF NUCLEAR MEDICINE, 27(5) (5), 452 - 459, English
    [Refereed]
    Scientific journal

  • Takashi Katsube, Masahiro Okada, Seishi Kumano, Izumi Imaoka, Yuki Kagawa, Masatoshi Hori, Kazunari Ishii, Noboru Tanigawa, Yasuharu Imai, Masatoshi Kudo, Takamichi Murakami
    Jun. 2013, European Journal of Radiology, 82(6) (6), 1039, English
    [Refereed]
    Scientific journal

  • Emi Sato, Shinichi Imafuku, Kazunari Ishii, Ryota Itoh, Bin Chou, Toshinori Soejima, Juichiro Nakayama, Kenji Hiromatsu
    Jun. 2013, JOURNAL OF DERMATOLOGICAL SCIENCE, 70(3) (3), 166 - 172, English
    [Refereed]
    Scientific journal

  • Hiroaki Kazui, Etsuro Mori, Shingo Ohkawa, Takaharu Okada, Takeo Kondo, Ryuji Sakakibara, Osamu Ueki, Yoshiyuki Nishio, Kazunari Ishii, Tetsuro Kawaguchi, Masatsune Ishikawa, Masatoshi Takeda
    May 2013, JOURNAL OF THE NEUROLOGICAL SCIENCES, 328(1-2) (1-2), 64 - 69, English
    [Refereed]
    Scientific journal

  • Kenta Sakaguchi, Makoto Hosono, Masakazu Otsuka, Kohei Hanaoka, Kimio Usami, Tatsuro Uto, Kazunari Ishii
    Jan. 2013, ANNALS OF NUCLEAR MEDICINE, 27(1) (1), 65 - 73, English
    [Refereed]
    Scientific journal

  • Ishii K, Soma T, Shimada K, Oda H, Terashima A, Kawasaki R
    1, Jan. 2013, Dementia and geriatric cognitive disorders extra, 3(1) (1), 489 - 496
    [Refereed]

  • 小野田 農, 岡田 真広, 兵藤 朋子, 松木 充, 石井 一成, 宇都 辰郎, 村上 卓道
    (株)メジカルビュー社, Dec. 2012, 臨床画像, 28(12) (12), 1444 - 1451, Japanese

  • The Usefullness of Conventional MR imaging in Establishing the Daiagnosis of Submandibular Pleomorphic Adenoma.
    柏木 伸夫, 高橋 洋人, 前西 修, 岡嶋 馨, 村上 卓道, 石井 一成, 中西 克之
    Nov. 2012

  • Seishi Kumano, Masahiro Okada, Taro Shimono, Masatomo Kuwabara, Yukinobu Yagyu, Izumi Imaoka, Ryuichiro Ashikaga, Kazunari Ishii, Takamichi Murakami
    Nov. 2012, EUROPEAN JOURNAL OF RADIOLOGY, 81(11) (11), 2953 - 2960, English
    [Refereed]
    Scientific journal

  • Tetsuya Fujigai, Seishi Kumano, Masahiro Okada, Tomoko Hyodo, Izumi Imaoka, Yukinobu Yagyu, Ryuichiro Ashikaga, Kazunari Ishii, Takamichi Murakami
    Nov. 2012, EUROPEAN JOURNAL OF RADIOLOGY, 81(11) (11), 2978 - 2983, English
    [Refereed]
    Scientific journal

  • Etsuro Mori, Masatsune Ishikawa, Takeo Kato, Hiroaki Kazui, Hiroji Miyake, Masakazu Miyajima, Madoka Nakajima, Masaaki Hashimoto, Nagato Kuriyama, Takahiko Tokuda, Kazunari Ishii, Mitsunobu Kaijima, Yoshihumi Hirata, Makoto Saito, Hajime Arai
    Nov. 2012, NEUROLOGIA MEDICO-CHIRURGICA, 52(11) (11), 775 - 809, English
    [Refereed]
    Scientific journal

  • レビー小体型認知症の頭頂側頭連合野の代謝低下はアミロイド沈着によらない
    石井 一成, 兵頭 朋子, 坂口 健太, 花岡 宏平, 宇佐美 公男, 島元 健次, 山添 譲, 山田 穣, 松木 充, 細野 眞, 村上 卓道
    (一社)日本核医学会, Nov. 2012, 核医学, 49(4) (4), 435 - 435, Japanese

  • 認知症における脳FDG‐PET早期撮像の可能性について
    兵頭朋子, 石井一成, 坂口健太, 花岡宏平, 宇佐美公男, 島元健次, 山添譲, 山田穣, 松木充, 細野眞, 村上卓道
    (一社)日本核医学会, Aug. 2012, 核医学, 49(3) (3), S274 - S274, Japanese

  • SPECT/CTを用いたバセドウ病のヨウ素131治療計画
    細野眞, 花岡宏平, 米矢吉宏, 土屋典生, 坂口健太, 高田裕史, 森元英夫, 宇佐美公男, 石井一成
    Aug. 2012, 核医学症例検討会症例集, 33(1) (1), 15-16, Japanese

  • Bin Chou, Kenji Hiromatsu, Shinji Okano, Kazunari Ishii, Xuefeng Duan, Tohru Sakai, Shigeo Murata, Keiji Tanaka, Kunisuke Himeno
    Aug. 2012, JOURNAL OF IMMUNOLOGY, 189(4) (4), 1618 - 1626, English
    [Refereed]
    Scientific journal

  • Takashi Katsube, Masahiro Okada, Seishi Kumano, Izumi Imaoka, Yuki Kagawa, Masatoshi Hori, Kazunari Ishii, Noboru Tanigawa, Yasuharu Imai, Masatoshi Kudo, Takamichi Murakami
    Jul. 2012, EUROPEAN JOURNAL OF RADIOLOGY, 81(7) (7), 1460 - 1464, English
    [Refereed]
    Scientific journal

  • Masahiro Okada, Kazunari Ishii, Kazushi Numata, Tomoko Hyodo, Seishi Kumano, Masayuki Kitano, Masatoshi Kudo, Takamichi Murakami
    Jun. 2012, HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, 11(3) (3), 307 - 313, English
    Scientific journal

  • Masahiro Okada, Kazunari Ishii, Kazushi Numata, Tomoko Hyodo, Seishi Kumano, Masayuki Kitano, Masatoshi Kudo, Takamichi Murakami
    Jun. 2012, HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, 11(3) (3), 307 - 313, English
    [Refereed]
    Scientific journal

  • Masahiro Okada, Kazunari Ishii, Kazushi Numata, Tomoko Hyodo, Seishi Kumano, Masayuki Kitano, Masatoshi Kudo, Takamichi Murakami
    Jun. 2012, HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, 11(3) (3), 307 - 313, English
    [Refereed]
    Scientific journal

  • Izumi Imaoka, Takayuki Nakatsuka, Tetsuro Araki, Takashi Katsube, Masahiro Okada, Seishi Kumano, Kazunari Ishii, Ryuichiro Ashikaga, Tomoyuki Okuaki, Marc Van Cauteren, Takamichi Murakami
    May 2012, ACTA RADIOLOGICA, 53(4) (4), 473 - 477, English
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Kohei Hanaoka, Masahiro Okada, Seishi Kumano, Yoshihiro Komeya, Norio Tsuchiya, Makoto Hosono, Takamichi Murakami
    Apr. 2012, ANNALS OF NUCLEAR MEDICINE, 26(3) (3), 241 - 247, English
    [Refereed]
    Scientific journal

  • 131I甲状腺内用療法におけるSPECT/CTを用いた甲状腺重量測定について
    花岡宏平, 大塚正和, 吉田修平, 井上亮, 石井一成, 村上卓道, 細野眞
    (公社)日本放射線技術学会, Feb. 2012, 日本放射線技術学会総会学術大会予稿集, 68回, 185 - 186, Japanese

  • 脳FDG集積低下を示す大きな腫瘍代謝症例の分析
    細野眞, 花岡宏平, 米矢吉宏, 土屋典生, 宇佐美公男, 高田裕史, 坂口健太, 森元英夫, IM Sung‐Woon, 石井一成, 辰巳陽一, 下野太郎
    Feb. 2012, 核医学症例検討会症例集, 32(2) (2), 41-42, Japanese

  • 岡田 真広, 石井 一成, 村上 卓道
    2012, Hepatobiliary & Pancreatic Diseases International

  • Ryuji Sakakibara, Yoshitaka Uchida, Kazunari Ishii, Hiromitsu Kazui, Masaaki Hashimoto, Masaaki Ishikawa, Tatsuhiko Yuasa, Masahiko Kishi, Emina Ogawa, Fuyuki Tateno, Tomoyuki Uchiyama, Tatsuya Yamamoto, Tomonori Yamanishi, Hitoshi Terada
    Jan. 2012, NEUROUROLOGY AND URODYNAMICS, 31(1) (1), 50 - 55, English
    [Refereed]
    Scientific journal

  • Shoji Kawashima, Kengo Ito, Takashi Kato
    BACKGROUND: Mild cognitive impairment (MCI) is considered to represent a transitional stage between ageing and Alzheimer's disease (AD). To aim at identifying neuroimaging measures associated with cognitive changes in healthy elderly and MCI patients, longitudinal multicentre studies are ongoing in several countries. The patient profiles of each study are based on unique inclusion criteria. OBJECTIVES: The purpose of the study is to clarify differences in baseline profiles of MCI patients between Studies on Diagnosis of Early Alzheimer's Disease-Japan (SEAD-J) and Alzheimer's Disease Neuroimaging Initiative (ADNI) and to examine the association between baseline profiles and risk of early conversion to AD. DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: SEAD-J recruited 114 patients from nine facilities in Japan. A total of 200 patients in ADNI with fluorodeoxyglucose-positron emission tomography (FDG-PET) were enrolled from the USA. METHODS: Baseline profiles were statistically analysed. For FDG-PET at a time of inclusion, associations between each profile and cerebral metabolic rate for glucose (CMRgl) were examined using SPM5 software. In each study, the ratio of conversion to AD within the 1-year and 2-year period after inclusion was investigated and differences in baseline profiles between AD converters and non-converters were analysed. RESULTS: SEAD-J included MCI patients with more severe verbal memory deficits and extracted patients with higher depressive tendencies. These differences were likely to be associated with criteria. SEAD-J exhibited a higher rate of conversion within 1 year compared with ADNI (24.5% vs 13.5%). In FDG-PET analyses of SEAD-J, AD converters within 1 year showed more severe decrease of FDG uptake in bilateral inferior parietal regions compared with non-converters. CONCLUSIONS: Different inclusion criteria provided differences in baseline profiles. The severity of memory deficit might cause increase of the AD conversion within 1 year. Clinical outcomes of multicentre studies for early diagnosis of AD should be interpreted carefully considering profiles of patients.
    2012, BMJ open, 2(2) (2), e000773, English, International magazine
    Scientific journal

  • 18F‐FDG PET/CTにてsuperscanを呈した腎癌骨転移の1例
    兵頭朋子, 石井一成, 細野眞, 阪本祐一, 米矢吉宏, 柳生行伸, 土屋典生, 熊野正士, 足利竜一朗, 中村一郎, 植村天受, 村上卓道
    (一社)日本核医学会, Nov. 2011, 核医学, 48(4) (4), 471 - 471, Japanese

  • Akiko Yamazaki, Michio Yasunami, Michael Ofori, Hitomi Horie, Mihoko Kikuchi, Gideon Helegbe, Akiko Takaki, Kazunari Ishii, Ahmeddin Hassan Omar, Bartholomew D. Akanmori, Kenji Hirayama
    Oct. 2011, HUMAN IMMUNOLOGY, 72(10) (10), 881 - 888, English
    [Refereed]
    Scientific journal

  • Kohei Hanaoka, Makoto Hosono, Kimio Usami, Yoichi Tatsumi, Yuzuru Yamazoe, Yoshihiro Komeya, Norio Tsuchiya, Kazunari Ishii, Mitsugu Sumita
    Aug. 2011, NUCLEAR MEDICINE COMMUNICATIONS, 32(8) (8), 678 - 683, English
    [Refereed]
    Scientific journal

  • Ryuichi Takahashi, Kazunari Ishii, Tatsuya Kakigi, Kazumasa Yokoyama
    Jul. 2011, HUMAN BRAIN MAPPING, 32(7) (7), 1050 - 1058, English
    [Refereed]
    Scientific journal

  • Masahiro Okada, Takashi Katsube, Seishi Kumano, Yuki Kagawa, Tetsuro Araki, Natsuko Tsuda, Tomoyuki Okuaki, Izumi Imaoka, Noboru Tanigawa, Kazunari Ishii, Takamichi Murakami
    Jul. 2011, ACTA RADIOLOGICA, 52(6) (6), 658 - 664, English
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Takafumi Uemura, Naokazu Miyamoto, Toshiki Yoshikawa, Toshiaki Yamaguchi, Tatsuhiko Ashihara, Yukihiro Ohtani
    May 2011, ANNALS OF NUCLEAR MEDICINE, 25(4) (4), 255 - 260, English
    [Refereed]
    Scientific journal

  • Interrater variability of image interpretation for F-18-FDG and C-11-PIB PET in the diagnosis of Alzheimer's disease
    Tomohiko Yamane, Hidehito Nagai, Tomoyuki Nishio, Yasuhiko Ikari, Yoko Makishi, Kazunari Ishii, Kenji Ishii, Takashi Kato, Kengo Ito, Michio Senda
    May 2011, JOURNAL OF NUCLEAR MEDICINE, 52, English

  • Takashi Katsube, Masahiro Okada, Seishi Kumano, Masatoshi Hori, Izumi Imaoka, Kazunari Ishii, Masatoshi Kudo, Hajime Kitagaki, Takamichi Murakami
    Apr. 2011, INVESTIGATIVE RADIOLOGY, 46(4) (4), 277 - 283, English
    [Refereed]
    Scientific journal

  • Yuki Kagawa, Masahiro Okada, Seishi Kumano, Takashi Katsube, Izumi Imaoka, Noboru Tanigawa, Kazunari Ishii, Masatoshi Kudo, Takamichi Murakami
    Apr. 2011, JOURNAL OF MAGNETIC RESONANCE IMAGING, 33(4) (4), 864 - 872, English
    [Refereed]
    Scientific journal

  • T. Uemura, K. Ishii, N. Miyamoto, T. Yoshikawa
    Mar. 2011, AMERICAN JOURNAL OF NEURORADIOLOGY, 32(3) (3), 556 - 559, English
    [Refereed]
    Scientific journal

  • 朝戸 信行, 岡田 真広, 熊野 正士, 藤谷 哲也, 柳生 行伸, 柏木 伸夫, 小塚 健倫, 今岡 いずみ, 足利 竜一朗, 石井 一成, 村上 卓道
    (株)メジカルビュー社, Mar. 2011, 臨床画像, 27(3) (3), 342 - 347, Japanese

  • 米矢 吉宏, 細野 眞, 土屋 典生, 熊野 正士, 任 誠雲, 柳生 行伸, 岡田 真広, 小塚 健倫, 今岡 いずみ, 石井 一成, 足利 竜一郎, 村上 卓道, 柴田 徹, 西村 恭昌
    (一社)日本核医学会, Feb. 2011, 核医学, 48(1) (1), 67 - 67, Japanese

  • 坂口 健太, 高田 裕史, 宇佐美 公男, 米矢 吉宏, 土屋 典生, 熊野 正士, 細野 眞, 花岡 宏平, 大塚 正和, 井上 亮, 新谷 祐子, 吉田 修平, 森元 英夫, 宇都 辰郎, 澄田 貢, 柿木 崇秀, 柳生 行伸, 石井 一成, 足利 竜一郎, 村上 卓道
    (一社)日本核医学会, Feb. 2011, 核医学, 48(1) (1), 63 - 64, Japanese

  • Brain Alterations and Mini-Mental State Examination in Patients with Progressive Supranuclear Palsy: Voxel-Based Investigations Using 18F-Fluorodeoxyglucose Positron Emission Tomography and Magnetic Resonance Imaging.
    高橋 竜一, 石井 一成, 村上 卓道, 横山 和正, 柿木 達也, 森 悦朗
    2011, Dement Geriatr Cogn Dis Extra, 1, 381 - 392

  • Yoshiyuki Nishio, Mamoru Hashimoto, Kazunari Ishii, Etsuro Mori
    BMJ Publishing Group, 2011, Journal of Neurology, Neurosurgery and Psychiatry, 82(11) (11), 1195 - 1200, English
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Masaaki Hashimoto, Kohei Hayashida, Kazuo Hashikawa, Chia-Cheng Chang, Jyoji Nakagawara, Teiji Nakayama, Satoru Mori, Ryuji Sakakibara
    2011, DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 32(1) (1), 1 - 10, English
    [Refereed]
    Scientific journal

  • Takahashi R, Ishii K, Kakigi T, Yokoyama K, Mori E, Murakami T
    1, Jan. 2011, Dementia and geriatric cognitive disorders extra, 1(1) (1), 381 - 392
    [Refereed]

  • 岡田 真広, 香川 祐毅, 熊野 正士, 柳生 行伸, 任 誠雲, 今岡 いずみ, 足利 竜一朗, 石井 一成, 山田 浩司, 工藤 正幸, 工藤 正俊, 村上 卓道
    (株)医学書院, Jan. 2011, 肝胆膵画像, 13(1) (1), 37 - 44, Japanese

  • Kohei Hanaoka, Makoto Hosono, Taro Shimono, Kimio Usami, Yoshihiro Komeya, Norio Tsuchiya, Yuzuru Yamazoe, Kazunari Ishii, Youichi Tatsumi, Mitsugu Sumita
    Dec. 2010, ANNALS OF NUCLEAR MEDICINE, 24(10) (10), 707 - 711, English
    [Refereed]
    Scientific journal

  • R. Takahashi, K. Ishii, N. Miyamoto, T. Yoshikawa, K. Shimada, S. Ohkawa, T. Kakigi, K. Yokoyama
    Nov. 2010, AMERICAN JOURNAL OF NEURORADIOLOGY, 31(10) (10), 1873 - 1878, English
    [Refereed]
    Scientific journal

  • Estimation of Liver Function Using T1 Mapping on Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid-enhanced Magnetic Resonance Imaging.
    Katsube T, Okada M, Kumano S, Hori M, Imaoka I, Ishii K, Kudo M, Kitagaki H, Murakami T
    Lippincott Williams & Wilkins, Aug. 2010, Invest Radiol, 46, 277 - 283, English
    [Refereed]
    Scientific journal

  • Masahiro Okada, Norihide Sato, Kazunari Ishii, Kaname Matsumura, Makoto Hosono, Takamichi Murakami
    Jul. 2010, RADIOGRAPHICS, 30(4) (4), 939 - 960, English
    [Refereed]
    Scientific journal

  • Atsushi K Kono, Kazunari Ishii, Hiroyuki Kumagai, Yasuyo Taniguchi, Teishi Kajiya, Kazuro Sugimura
    Jun. 2010, Japanese journal of radiology, 28(5) (5), 355 - 61, English, Domestic magazine
    [Refereed]
    Scientific journal

  • H. Goto, K. Ishii, T. Uemura, N. Miyamoto, T. Yoshikawa, K. Shimada, S. Ohkawa
    Apr. 2010, American Journal of Neuroradiology, 31(4) (4), 720 - 725, English
    [Refereed]
    Scientific journal

  • Ryuichi Takahashi, Kazunari Ishii, Kenichi Shimada, Shingo Ohkawa, Yo Nishimura
    Jan. 2010, Journal of the neurological sciences, 288(1-2) (1-2), 88 - 91, English, International magazine
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Tomonori Kanda, Takafumi Uemura, Naokazu Miyamoto, Toshiki Yoshikawa, Kenichi Shimada, Shingo Ohkawa, Satoshi Minoshima
    May 2009, European journal of nuclear medicine and molecular imaging, 36(5) (5), 831 - 40, English, International magazine
    [Refereed]
    Scientific journal

  • Toshiaki Yamaguchi, Osamu Ueda, Hideyuki Hara, Hiroto Sakai, Tohru Kida, Kayo Suzuki, Shuji Adachi, Kazunari Ishii
    Jan. 2009, ANNALS OF NUCLEAR MEDICINE, 23(1) (1), 65 - 71, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Tomonori Kanda, Kazunari Ishii, Takafumi Uemura, Naokazu Miyamoto, Toshiki Yoshikawa, Atsushi K Kono, Etsuro Mori
    Dec. 2008, European journal of nuclear medicine and molecular imaging, 35(12) (12), 2227 - 34, English, International magazine
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Tomonori Kanda, Aya Harada, Naokazu Miyamoto, Tetsuro Kawaguchi, Kenichi Shimada, Shingo Ohkawa, Takafumi Uemura, Toshiki Yoshikawa, Etsuro Mori
    Nov. 2008, European radiology, 18(11) (11), 2678 - 83, English, International magazine
    [Refereed]
    Scientific journal

  • Yumiko Yamane, Kazunari Ishii, Kotaro Shimizu, Keitaro Sofue, Toshiki Yoshikawa, Naokazu Miyamoto, Shingo Ohkawa
    May 2008, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 32(3) (3), 415 - 417, English
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Tetsuro Kawaguchi, Kenichi Shimada, Shingo Ohkawa, Naokazu Miyamoto, Tomonori Kanda, Takafumi Uemura, Toshiki Yoshikawa, Etsuro Mori
    2008, Dementia and geriatric cognitive disorders, 25(4) (4), 329 - 35, English, International magazine
    [Refereed]
    Scientific journal

  • Atsushi K Kono, Kazunari Ishii, Keitaro Sofue, Naokazu Miyamoto, Setsu Sakamoto, Etsuro Mori
    Sep. 2007, European journal of nuclear medicine and molecular imaging, 34(9) (9), 1490 - 7, English, International magazine
    [Refereed]
    Scientific journal

  • Yoshiyuki Nishio, Kazunari Ishii, Hiroaki Kazui, Yoshiyuki Hosokai, Etsuro Mori
    Sep. 2007, JOURNAL OF THE NEUROLOGICAL SCIENCES, 260(1-2) (1-2), 271 - 274, English
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Tsutomu Soma, Atsushi K Kono, Keitaro Sofue, Naokazu Miyamoto, Toshiki Yoshikawa, Etsuro Mori, Kenya Murase
    May 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 48(5) (5), 704 - 11, English, International magazine
    [Refereed]
    Scientific journal

  • Kohkichi Hosoda, Kazunari Ishii, Satoshi Minoshima, Eiji Kohmura
    Jan. 2007, Journal of neurosurgery, 106(1) (1), 119 - 27, English, International magazine
    [Refereed]
    Scientific journal

  • Hiroki Sasaki, Kazunari Ishii, Atsushi K Kono, Naokazu Miyamoto, Tetsuya Fukuda, Kenichi Shimada, Shingo Ohkawa, Tetsuro Kawaguchi, Etsuro Mori
    Jan. 2007, Annals of nuclear medicine, 21(1) (1), 39 - 45, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Hiroki Sasaki, Kazunari Ishii, Atsushi K. Kono, Naokazu Miyamoto, Tetsuya Fukuda, Kenichi Shimada, Shingo Ohkawa, Tetsuro Kawaguchi, Etsuro Mori
    Jan. 2007, ANNALS OF NUCLEAR MEDICINE, 21(1) (1), 39 - 45, English
    [Refereed]
    Scientific journal

  • Atsushi K Kono, Tetsuya Fukuda, Yuji Shibata, Masaki Iwakura, Hideki Komatsu, Hiroki Sasaki, Tetsuro Kawaguchi, Kazunari Ishii
    8, Oct. 2006, Radiation medicine, 24(8) (8), 577 - 82, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Takashi Kawachi, Kazunari Ishii, Setsu Sakamoto, Masahiro Sasaki, Tetsuya Mori, Fumio Yamashita, Hiroshi Matsuda, Etsuro Mori
    Jul. 2006, European journal of nuclear medicine and molecular imaging, 33(7) (7), 801 - 9, English, International magazine
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Tsutomu Soma, Atsushi K Kono, Hiroki Sasaki, Naokazu Miyamoto, Tetsuya Fukuda, Kenya Murase
    6, Jul. 2006, Radiation medicine, 24(6) (6), 422 - 30, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Hiroki Sasaki, Kazunari Ishii, Atsushi K Kono, Naokazu Miyamoto, Tetsuya Fukuda, Junko Kanata, Yasushi Kita
    6, Jul. 2006, Radiation medicine, 24(6) (6), 463 - 6, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Atsushi K Kono, Hiroki Sasaki, Naokazu Miyamoto, Tetsuya Fukuda, Setsu Sakamoto, Etsuro Mori
    May 2006, European journal of nuclear medicine and molecular imaging, 33(5) (5), 575 - 83, English, International magazine
    [Refereed]
    Scientific journal

  • K Ishii, Y Higashi, M Tabata, M Miyaishi, T Mizutani, M Sasaki
    May 2006, ANNALS OF NUCLEAR MEDICINE, 20(4) (4), 329 - 331, English
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Yasuto Higashi, Masako Tabata, Masahiro Miyaishi, Takashi Mizutani, Masahiro Sasaki
    May 2006, Annals of nuclear medicine, 20(4) (4), 329 - 31, English, Domestic magazine
    [Refereed]
    Scientific journal

  • K Ishii, H Hisaeda, XF Duan, T Imai, T Sakai, HJ Fehling, S Murata, T Chiba, K Tanaka, S Hamano, M Sano, A Yano, K Himeno
    Apr. 2006, MICROBES AND INFECTION, 8(4) (4), 1045 - 1053, English
    [Refereed]
    Scientific journal

  • Wenxiang Quan, Minoru Yasuda, Mamoru Hashimoto, Yasuji Yamamoto, Kazunari Ishii, Hiroaki Kazui, Etsuro Mori, Tatsuya Kakigi, Kiyoshi Maeda
    Jan. 2006, Journal of the neurological sciences, 240(1-2) (1-2), 71 - 5, English, International magazine
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Satoshi Minoshima
    Dec. 2005, European journal of nuclear medicine and molecular imaging, 32(12) (12), 1463 - 5, English, International magazine
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Hiroki Sasaki, Atsushi K Kono, Naokazu Miyamoto, Tetsuya Fukuda, Etsuro Mori
    Aug. 2005, European journal of nuclear medicine and molecular imaging, 32(8) (8), 959 - 63, English, International magazine
    [Refereed]
    Scientific journal

  • A Takeda, S Hamano, H Shiraishi, T Yoshimura, H Ogata, K Ishii, T Ishibashi, A Yoshimura, H Yoshida
    Jul. 2005, INTERNATIONAL IMMUNOLOGY, 17(7) (7), 889 - 897, English
    [Refereed]
    Scientific journal

  • K Hosoda, T Kawaguchi, K Ishii, S Minoshima, E Kohmura
    Jul. 2005, NEUROSURGERY, 57(1) (1), 32 - 40, English
    [Refereed]
    Scientific journal

  • Kohkichi Hosoda, Tetsuro Kawaguchi, Kazunari Ishii, Satoshi Minoshima, Eiji Kohmura
    Jul. 2005, Neurosurgery, 57(1) (1), 32 - 41, English, International magazine
    [Refereed]
    Scientific journal

  • Detectability of hypometabolic regions in mild Alzheimer disease: function of time after the injection of 2-[fluorine 18]-fluoro-2-deoxy-D-glucose.
    Setsu Sakamoto, Kazunari Ishii, Kayo Hosaka, Tetsuya Mori, Masahiro Sasaki, Etsuro Mori
    Apr. 2005, AJNR. American journal of neuroradiology, 26(4) (4), 843 - 7, English, International magazine
    [Refereed]
    Scientific journal

  • Voxel-based morphometric comparison between early- and late-onset mild Alzheimer's disease and assessment of diagnostic performance of z score images.
    Kazunari Ishii, Takashi Kawachi, Hiroki Sasaki, Atsushi K Kono, Tetsuya Fukuda, Yoshio Kojima, Etsuro Mori
    Feb. 2005, AJNR. American journal of neuroradiology, 26(2) (2), 333 - 40, English, International magazine
    [Refereed]
    Scientific journal

  • K Hosaka, K Ishii, S Sakamoto, N Sadato, H Fukuda, T Kato, K Sugimura, M Senda
    Jan. 2005, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 32(1) (1), 92 - 97, English
    [Refereed]
    Scientific journal

  • アルツハイマー病の発症におけるプレセニリン2遺伝子の役割
    YASUDA, Minoru, 石井一成, 橋本衛, 数井裕光, 谷向知, 博野信次, 森悦朗, 片山量平, 富田泰輔, 岩坪威, 権文香, YAMAMOTO, Yasuji, KAWAMATA, Toshio, MAEDA, Kiyoshi
    Dec. 2004, 臨床神経学, 44巻, 12号, pp. 1088-1088(12) (12), Japanese
    International conference proceedings

  • Evaluation of cortical atrophy between progressive supranuclear palsy and corticobasal degeneration by hemispheric surface display of MR images
    M Taki, K Ishii, T Fukuda, Y Kojima, E Mori
    Nov. 2004, AMERICAN JOURNAL OF NEURORADIOLOGY, 25(10) (10), 1709 - 1714, English
    [Refereed]
    Scientific journal

  • MX Zhang, K Ishii, H Hisaeda, S Murata, T Chiba, K Tanaka, Y Li, C Obata, M Furue, K Himeno
    Aug. 2004, IMMUNOLOGY, 112(4) (4), 567 - 574, English
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Kayo Hosaka, Tetsuya Mori, Etsuro Mori
    Jul. 2004, Annals of nuclear medicine, 18(5) (5), 447 - 51, English, Domestic magazine
    [Refereed]
    Scientific journal

  • H Ito, Kanno, I, C Kato, T Sasaki, K Ishii, Y Ouchi, A Iida, H Okazawa, K Hayashida, N Tsuyuguchi, K Ishii, Y Kuwabara, M Senda
    May 2004, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 31(5) (5), 635 - 643, English
    [Refereed]
    Scientific journal

  • K Onishi, Y Li, K Ishii, H Hisaeda, LJ Tang, XF Duan, T Dainichi, Y Maekawa, N Katunuma, K Himeno
    Apr. 2004, MICROBES AND INFECTION, 6(5) (5), 468 - 474, English
    [Refereed]
    Scientific journal

  • Atsushi Yamanaka, Shinjiro Hamano, Yoshiyuki Miyazaki, Kazunari Ishii, Atsunobu Takeda, Tak W. Mak, Kunisuke Himeno, Akihiko Yoshimura, Hiroki Yoshida
    American Association of Immunologists, Mar. 2004, Journal of Immunology, 172(6) (6), 3590 - 3596, English
    [Refereed]
    Scientific journal

  • Nobutsugu Hirono, Mamoru Hashimoto, Kazunari Ishii, Hiroaki Kazui, Etsuro Mori
    American Psychiatric Publishing Inc., 2004, Journal of Neuropsychiatry and Clinical Neurosciences, 16(4) (4), 488 - 492, English
    [Refereed]
    Scientific journal

  • M Senda, Y Ouchi, K Ishii, K Ishii, S Ikeda
    2004, PET AND MOLECULAR IMAGING: STATE OF THE ART AND FUTURE PERSPECTIVES, 1264, 33 - 39, English
    [Refereed]
    International conference proceedings

  • Kazunari Ishii, Tetsuya Mori, Nobutsugu Hirono, Etsuro Mori
    Nov. 2003, Journal of the neurological sciences, 215(1-2) (1-2), 71 - 4, English, International magazine
    [Refereed]
    Scientific journal

  • K Ishii, T Mori, N Hirono, E Mori
    Nov. 2003, JOURNAL OF THE NEUROLOGICAL SCIENCES, 215(1-2) (1-2), 71 - 74, English
    [Refereed]
    Scientific journal

  • Y. Nishio, Y. Nakano, K. Matsumoto, M. Hashimoto, H. Kazul, N. Hirono, K. Ishii, Etsuro Mori
    Jul. 2003, European Journal of Neurology, 10(4) (4), 457 - 460, English
    Scientific journal

  • Kohkichi Hosoda, Tetsuro Kawaguchi, Kazunari Ishii, Satoshi Minoshima, Yuji Shibata, Masaki Iwakura, Shigeo Ishiguro, Eiji Kohmura
    May 2003, Stroke, 34(5) (5), 1187 - 93, English, International magazine
    [Refereed]
    Scientific journal

  • Lewy小体性痴呆における18FDG-PETと123I-IMP SPECTの所見の対比
    保坂 加代, 山口 雅人, 福島 和人, 杉村 和朗, 石井 一成
    (公社)日本医学放射線学会, Feb. 2003, 日本医学放射線学会雑誌, 63(3) (3), 114 - 115, Japanese
    [Refereed]

  • Kazunari Ishii
    Dec. 2002, Annals of nuclear medicine, 16(8) (8), 515 - 25, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Setsu Sakamoto, Kazunari Ishii, Masahiro Sasaki, Kayo Hosaka, Tetsuya Mori, Mieko Matsui, Nobutsugu Hirono, Etsuro Mori
    Aug. 2002, Journal of the neurological sciences, 200(1-2) (1-2), 27 - 32, English, International magazine
    [Refereed]
    Scientific journal

  • S Sakamoto, K Ishii, M Sasaki, K Hosaka, T Mori, M Matsui, N Hirono, E Mori
    Aug. 2002, JOURNAL OF THE NEUROLOGICAL SCIENCES, 200(1-2) (1-2), 27 - 32, English
    [Refereed]
    Scientific journal

  • Kayo Hosaka, Kazunari Ishii, Setsu Sakamoto, Tetsuya Mori, Masahiro Sasaki, Nobutsugu Hirono, Etsuro Mori
    Jul. 2002, Journal of the neurological sciences, 199(1-2) (1-2), 67 - 71, English, International magazine
    [Refereed]
    Scientific journal

  • Takashi Kawachi, Kazunari Ishii, Setsu Sakamoto, Mieko Matsui, Tetsuya Mori, Masahiro Sasaki
    Jul. 2002, Journal of the neurological sciences, 199(1-2) (1-2), 79 - 83, English, International magazine
    [Refereed]
    Scientific journal

  • T Kawachi, K Ishii, S Sakamoto, M Matsu, T Mori, M Sasaki
    Jul. 2002, JOURNAL OF THE NEUROLOGICAL SCIENCES, 199(1-2) (1-2), 79 - 83, English
    [Refereed]
    Scientific journal

  • K Hosaka, K Ishii, S Sakamoto, T Mori, M Sasaki, N Hirono, E Mori
    Jul. 2002, JOURNAL OF THE NEUROLOGICAL SCIENCES, 199(1-2) (1-2), 67 - 71, English
    [Refereed]
    Scientific journal

  • Kazunari Ishii, Setsu Sakamoto, Kayo Hosaka, Tetsuya Mori, Masahiro Sasaki
    Jun. 2002, Annals of nuclear medicine, 16(4) (4), 299 - 301, English, Domestic magazine
    [Refereed]
    Scientific journal

  • N Hirono, M Hashimoto, M Yasuda, K Ishii, S Sakamoto, H Kazui, E Mori
    Lippincott Williams and Wilkins, Mar. 2002, Neurology, 58(5) (5), 743 - 50, English, International magazine
    [Refereed]
    Scientific journal

  • M Matsui, T Imamura, S Sakamoto, K Ishii, H Kazui, E Mori
    Mar. 2002, Neuroradiology, 44(3) (3), 235 - 8, English, International magazine
    [Refereed]
    Scientific journal

  • M Nishitani, T Sakai, K Ishii, MX Zhang, Y Nakano, Y Nitta, J Miyazaki, H Kanayama, S Kagawa, K Himeno
    Feb. 2002, CANCER GENE THERAPY, 9(2) (2), 156 - 163, English
    [Refereed]
    Scientific journal

  • T Imamura, K Ishii, N Hirono, M Hashimoto, S Tanimukai, H Kazui, T Hanihara, M Sasaki, E Mori
    May 2001, DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 12(3) (3), 194 - 197, English
    Scientific journal

  • N Hirono, E Mori, K Ishii, T Imamura, S Tanimukai, H Kazui, M Hashimoto, Y Takatsuki, H Kitagaki, M Sasaki
    Jan. 2001, DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 12(1) (1), 15 - 21, English
    Scientific journal

  • A diagnostic method for suspected Alzheimer's disease using H(2)15O positron emission tomography perfusion Z score.
    K Ishii, M Sasaki, M Matsui, S Sakamoto, S Yamaji, N Hayashi, T Mori, H Kitagaki, N Hirono, E Mori
    Nov. 2000, Neuroradiology, 42(11) (11), 787 - 94, English, International magazine
    [Refereed]
    Scientific journal

  • Noninvasive estimation of FDG input function for quantification of cerebral metabolic rate of glucose: Optimization and multicenter evaluation
    T Shiozaki, N Sadato, M Senda, K Ishii, T Tsuchida, Y Yonekura, H Fukuda, J Konishi
    Oct. 2000, JOURNAL OF NUCLEAR MEDICINE, 41(10) (10), 1612 - 1618, English
    [Refereed]
    Scientific journal

  • Corticobasal degeneration: evaluation of cortical atrophy by means of hemispheric surface display generated with MR images.
    H Kitagaki, N Hirono, K Ishii, E Mori
    Jul. 2000, Radiology, 216(1) (1), 31 - 8, English, International magazine
    [Refereed]
    Scientific journal

  • N Hayashi, K Ishii, H Kitagaki, H Kazui
    Jun. 2000, Journal of the neurological sciences, 176(2) (2), 102 - 8, English, International magazine
    [Refereed]
    Scientific journal

  • Disturbances of spatial vision and object vision correlate differently with regional cerebral glucose metabolism in Alzheimer's disease.
    M Fujimori, T Imamura, N Hirono, K Ishii, M Sasaki, E Mori
    2000, Neuropsychologia, 38(10) (10), 1356 - 61, English, International magazine
    [Refereed]
    Scientific journal

  • Evaluation of standardized uptake value to assess cerebral glucose metabolism.
    S Yamaji, K Ishii, M Sasaki, T Mori, H Kitagaki, S Sakamoto, E Mori
    Jan. 2000, Clinical nuclear medicine, 25(1) (1), 11 - 6, English, International magazine
    [Refereed]
    Scientific journal

  • Low cerebral glucose extraction rates in the human medial temporal cortex and cerebellum
    S Sakamoto, K Ishii
    Jan. 2000, JOURNAL OF THE NEUROLOGICAL SCIENCES, 172(1) (1), 41 - 48, English
    [Refereed]
    Scientific journal

  • Nobutsugu Hirono, Kazunari Ishii, Masahiro Sasaki, Hajime Kitagaki, Mamoru Hashimoto, Toru Imamura, Satoshi Tanimukai, Tokiji Hanihara, Hiroaki Kazui, Etsuro Mori
    S. Karger AG, 2000, Dementia and Geriatric Cognitive Disorders, 11(3) (3), 139 - 146, English
    Scientific journal

  • Role of functional brain imaging in the evaluation of vascular dementia
    E Mori, K Ishii, M Hashimoto, T Imamura, N Hirono, H Kitagaki
    Dec. 1999, ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 13, S91 - S101, English
    [Refereed]
    Scientific journal

  • Distinctive neurobehavioral features among neurodegenerative dementias
    Nobutsugu Hirono, Etsuro Mori, Satoshi Tanimukai, Hiroaki Kazui, Mamoru Hashimoto, Tokiji Hanihara, Toru Imamura
    Sep. 1999, Journal of Neuropsychiatry and Clinical Neurosciences, 11(4) (4), 498 - 503, English
    Scientific journal

  • Tc-99m ethyl cysteinate dimer SPECT and 2-[F-18]fluoro-2-deoxy-D-glucose PET in Alzheimer's disease. Comparison of perfusion and metabolic patterns.
    K Ishii, M Sasaki, S Sakamoto, S Yamaji, H Kitagaki, E Mori
    Aug. 1999, Clinical nuclear medicine, 24(8) (8), 572 - 5, English, International magazine
    [Refereed]
    Scientific journal

  • Regional cerebral glucose metabolism and blood flow in a patient with Marchiafava-Bignami disease.
    K Ishii, Y Ikerjiri, M Sasaki, H Kitagaki, E Mori
    Aug. 1999, AJNR. American journal of neuroradiology, 20(7) (7), 1249 - 51, English, International magazine
    [Refereed]
    Scientific journal

  • Regional cerebral blood flow difference between dementia with Lewy bodies and AD.
    K Ishii, S Yamaji, H Kitagaki, T Imamura, N Hirono, E Mori
    Jul. 1999, Neurology, 53(2) (2), 413 - 6, English, International magazine
    [Refereed]
    Scientific journal

  • Visual hallucinations and regional cerebral metabolism in dementia with Lewy bodies (DLB).
    T Imamura, K Ishii, N Hirono, M Hashimoto, S Tanimukai, H Kazuai, T Hanihara, M Sasaki, E Mori
    Jun. 1999, Neuroreport, 10(9) (9), 1903 - 7, English, International magazine
    [Refereed]
    Scientific journal

  • K Hojo, T Imamura, M Takanashi, K Ishii, M Sasaki, S Imura, R Ozono, Y Takatsuki, S Takauchi, E Mori
    Lippincott Williams and Wilkins, May 1999, European journal of neurology, 6(3) (3), 357 - 61, English, International magazine
    [Refereed]
    Scientific journal

  • Nobutsugu Hirono, Etsuro Mori, Minoru Yasuda, Toru Imamura, Tatsuo Shimomura, Mamoru Hashimoto, Satoshi Tanimukai, Hiroaki Kazui, Hikari Yamashita
    American Psychiatric Publishing Inc., 1999, Journal of Neuropsychiatry and Clinical Neurosciences, 11(1) (1), 66 - 70, English
    Scientific journal

  • Zenichiro Kato, Kanji Yasuda, Kazunari Ishii, Hajime Takagi, Shinji Mizuno, Nobuyuki Shimozawa, Naomi Kondo
    1999, Pediatrics International, 41(6) (6), 689 - 692, English
    [Refereed]
    Scientific journal

  • Lack of association of apolipoprotein E epsilon4 allele dose with cerebral glucose metabolism in Alzheimer disease.
    N Hirono, E Mori, M Yasuda, K Ishii, Y Ikejiri, T Imamura, T Shimomura, M Hashimoto, H Yamashita, M Sasaki
    Dec. 1998, Alzheimer disease and associated disorders, 12(4) (4), 362 - 7, English, International magazine
    [Refereed]
    Scientific journal

  • N Hirono, E Mori, K Ishii, T Imamura, T Shimomura, S Tanimukai, H Kazui, M Hashimoto, H Yamashita, M Sasaki
    BMJ Publishing Group, Dec. 1998, Journal of neurology, neurosurgery, and psychiatry, 65(6) (6), 913 - 6, English, International magazine
    [Refereed]
    Scientific journal

  • Relatively preserved hippocampal glucose metabolism in mild Alzheimer's disease
    K Ishii, M Sasaki, S Yamaji, S Sakamoto, H Kitagaki, E Mori
    Nov. 1998, DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 9(6) (6), 317 - 322, English
    [Refereed]
    Scientific journal

  • Cerebral glucose metabolism in patients with frontotemporal dementia.
    K Ishii, S Sakamoto, M Sasaki, H Kitagaki, S Yamaji, M Hashimoto, T Imamura, T Shimomura, N Hirono, E Mori
    Nov. 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 39(11) (11), 1875 - 8, English, International magazine
    [Refereed]
    Scientific journal

  • CSF spaces in idiopathic normal pressure hydrocephalus: morphology and volumetry.
    H Kitagaki, E Mori, K Ishii, S Yamaji, N Hirono, T Imamura
    Aug. 1998, AJNR. American journal of neuroradiology, 19(7) (7), 1277 - 84, English, International magazine
    [Refereed]
    Scientific journal

  • Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease.
    K Ishii, T Imamura, M Sasaki, S Yamaji, S Sakamoto, H Kitagaki, M Hashimoto, N Hirono, T Shimomura, E Mori
    Jul. 1998, Neurology, 51(1) (1), 125 - 30, English, International magazine
    [Refereed]
    Scientific journal

  • Bromocriptine treatment for perseveration in demented patients.
    T Imamura, M Takanashi, N Hattori, M Fujimori, H Yamashita, K Ishii, A Yamadori
    Jun. 1998, Alzheimer disease and associated disorders, 12(2) (2), 109 - 13, English, International magazine
    [Refereed]
    Scientific journal

  • Hypofunction in the posterior cingulate gyrus correlates with disorientation for time and place in Alzheimer's disease.
    N Hirono, E Mori, K Ishii, Y Ikejiri, T Imamura, T Shimomura, M Hashimoto, H Yamashita, M Sasaki
    Apr. 1998, Journal of neurology, neurosurgery, and psychiatry, 64(4) (4), 552 - 4, English, International magazine
    [Refereed]
    Scientific journal

  • Regional hypometabolism related to language disturbance in Alzheimer's disease
    N Hirono, E Mori, K Ishii, Y Ikejiri, T Imamura, T Shimomura, M Ikeda, H Yamashita, Y Takatsuki, M Sasaki
    Mar. 1998, DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 9(2) (2), 68 - 73, English
    [Refereed]
    Scientific journal

  • K Ishii, M Sasaki, S Yamaji, S Sakamoto, K Maeda
    Springer Tokyo, Feb. 1998, Annals of nuclear medicine, 12(1) (1), 29 - 33, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Frontal lobe hypometabolism and depression in Alzheimer's disease.
    N Hirono, E Mori, K Ishii, Y Ikejiri, T Imamura, T Shimomura, M Hashimoto, H Yamashita, M Sasaki
    Feb. 1998, Neurology, 50(2) (2), 380 - 3, English, International magazine
    [Refereed]
    Scientific journal

  • Paradoxical hippocampus perfusion in mild-to-moderate Alzheimer's disease.
    K Ishii, M Sasaki, S Yamaji, S Sakamoto, H Kitagaki, E Mori
    Feb. 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 39(2) (2), 293 - 8, English, International magazine
    [Refereed]
    Scientific journal

  • Utility of automated hemispheric surface display of MRI in diagnosing for cortical atrophy
    H Kitagaki, E Mori, K Ishii, S Kobashi, Y Hata
    1998, CAR '98 - COMPUTER ASSISTED RADIOLOGY AND SURGERY, 1165, 76 - 81, English
    [Refereed]
    International conference proceedings

  • Characterization of Fe(III)-deferoxamine and Mn(II)-pectin as magnetic resonance imaging contrast agents
    Yoshiki Mino, Hajime Kitagaki, Masahiro Sasaki, Kazunari Ishii, Tetsuya Mori, Katsuki Yamada, Osamu Nagasawa
    1998, Biological and Pharmaceutical Bulletin, 21(12) (12), 1385 - 1388, English
    [Refereed]
    Scientific journal

  • N Hirono, E Mori, K Ishii, H Kitagaki, M Sasaki, Y Ikejiri, T Imamura, T Shimomura, M Ikeda, H Yamashita
    American Psychiatric Publishing Inc., 1998, The Journal of neuropsychiatry and clinical neurosciences, 10(4) (4), 433 - 9, English, International magazine
    [Refereed]
    Scientific journal

  • H2O-PET perfusion Z score image for a diagnosis of Alzheimer's disease
    K Ishii, E Mori, M Sasaki, H Kitagaki, S Hirano, Y Hata
    1998, CAR '98 - COMPUTER ASSISTED RADIOLOGY AND SURGERY, 1165, 863 - 863, English
    [Refereed]
    International conference proceedings

  • T Imamura, K Ishii, M Sasaki, H Kitagaki, S Yamaji, N Hirono, T Shimomura, M Hashimoto, S Tanimukai, H Kazui, E Mori
    Oct. 1997, Neuroscience letters, 235(1-2) (1-2), 49 - 52, English, International magazine
    [Refereed]
    Scientific journal

  • Changes in cerebral blood flow and oxygen metabolism related to magnetic resonance imaging white matter hyperintensities in Alzheimer's disease.
    S Yamaji, K Ishii, M Sasaki, T Imamura, H Kitagaki, S Sakamoto, E Mori
    Sep. 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 38(9) (9), 1471 - 4, English, International magazine
    [Refereed]
    Scientific journal

  • Gadolinium enhancement of the cerebrospinal fluid in a patient with meningeal fibrosis and cryptococcal infection.
    S Sakamoto, H Kitagaki, K Ishii, S Yamaji, Y Ikejiri, E Mori
    Jul. 1997, Neuroradiology, 39(7) (7), 504 - 5, English, International magazine
    [Refereed]
    Scientific journal

  • Reduction of cerebellar glucose metabolism in advanced Alzheimer's disease.
    K Ishii, M Sasaki, H Kitagaki, S Yamaji, S Sakamoto, K Matsuda, E Mori
    Jun. 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 38(6) (6), 925 - 8, English, International magazine
    [Refereed]
    Scientific journal

  • Demonstration of decreased posterior cingulate perfusion in mild Alzheimer's disease by means of H215O positron emission tomography.
    K Ishii, M Sasaki, S Yamaji, S Sakamoto, H Kitagaki, E Mori
    Jun. 1997, European journal of nuclear medicine, 24(6) (6), 670 - 3, English, International magazine
    [Refereed]
    Scientific journal

  • Alteration of white matter MR signal intensity in frontotemporal dementia.
    H Kitagaki, E Mori, N Hirono, Y Ikejiri, K Ishii, T Imamura, M Ikeda, S Yamaji, H Yamashita, T Shimomura, Y Nakagawa
    Feb. 1997, AJNR. American journal of neuroradiology, 18(2) (2), 367 - 78, English, International magazine
    [Refereed]
    Scientific journal

  • K Matsuda, S Yamaji, K Ishii, M Sasaki, S Sakamoto, H Kitagaki, T Imamura, E Mori
    Springer Tokyo, Feb. 1997, Annals of nuclear medicine, 11(1) (1), 33 - 5, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Kazuhito Fukushima, Michio Kono, Kazunari Ishii, Eiro Sakai, Shozo Hirota, Hidehisa Yuri
    1997, European Journal of Nuclear Medicine, 24(11) (11), 1426 - 1428, English
    [Refereed]
    Scientific journal

  • Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS.
    Y Ikejiri, E Mori, K Ishii, K Nishimoto, M Yasuda, M Sasaki
    Aug. 1996, Neurology, 47(2) (2), 583 - 5, English, International magazine
    [Refereed]
    Scientific journal

  • Decreased medial temporal oxygen metabolism in Alzheimer's disease shown by PET.
    K Ishii, H Kitagaki, M Kono, E Mori
    Jul. 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 37(7) (7), 1159 - 65, English, International magazine
    [Refereed]
    Scientific journal

  • Regional difference in cerebral blood flow and oxidative metabolism in human cortex.
    K Ishii, M Sasaki, H Kitagaki, S Sakamoto, S Yamaji, K Maeda
    Jul. 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 37(7) (7), 1086 - 8, English, International magazine
    [Refereed]
    Scientific journal

  • The clinical utility of visual evaluation of scintigraphic perfusion patterns for Alzheimer's disease using I-123 IMP SPECT.
    K Ishii, E Mori, H Kitagaki, S Sakamoto, S Yamaji, T Imamura, Y Ikejiri, M Kono
    Feb. 1996, Clinical nuclear medicine, 21(2) (2), 106 - 10, English, International magazine
    [Refereed]
    Scientific journal

  • Interuncal Distance Measurements in Normal Controls and Patients with Dementia : MR Imaging Study
    ISHII Kazunari, KITAGAKI Hajime, SAKAMOTO Setsu, YAMAJI Shigeru, KONO Michio
    To evaluate the utility of measuring interuncal distance (IUD) as a reflection of the limbic system, we compared the IUD of 60 dementia patients with that of 10 normal controls. We also measured the width of the intracranial compartment (W1 and W2) to correct for differences in individual brain size, and calculated the ratio of IUD/W1 and IUD/W2. IUD could not separate patients with dementia from normal controls, but there were significant differences in IUD/W1 and IUD/W2 between patients with dementia and normal controls. IUD, IUD/W1 and IUD/W2 did not correlate with Mini-Mental Examination score or ADAS score in patients with dementia. We conclude that IUD measurement is not helpful in distinguishing patients with mild stage dementia from normal aged people or as a scale for dementia. However, we suggest that IUD/W1 and IUD/W2 can discriminate between cases of mild dementia and normal aged people.
    (公社)日本医学放射線学会, Aug. 1995, Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 55(9) (9), 646 - 650, Japanese, Domestic magazine

  • COMPARISON OF CARBON-DIOXIDE RESPONSIVENESS OF CEREBELLAR BLOOD-FLOW BETWEEN AFFECTED AND UNAFFECTED SIDES WITH CROSSED CEREBELLAR DIASCHISIS
    K ISHII, KANNO, I, K UEMURA, J HATAZAWA, T OKUDERA, A INUGAMI, T OGAWA, H FUJITA, E SHIMOSEGAWA
    Apr. 1994, STROKE, 25(4) (4), 826 - 830, English
    [Refereed]
    Scientific journal

  • HIGH L-METHYL-[C-11]METHIONINE UPTAKE IN BRAIN-ABSCESS - A PET STUDY
    K ISHII, T OGAWA, J HATAZAWA, KANNO, I, A INUGAMI, H FUJITA, E SHIMOSEGAWA, M MURAKAMI, T OKUDERA, K UEMURA
    Jul. 1993, JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 17(4) (4), 660 - 661, English
    [Refereed]
    Scientific journal

  • Two cases of hepatobiliary scintigraphy of liver transplantation in rejection
    K. Kanegawa, S. Nishiyama, T. Muraji, K. Ishii, M. Kouno
    1992, Kakuigaku, 29(4) (4), 501 - 504, Japanese
    [Refereed]
    Scientific journal

  • Preparation of new 7-hydroxyguanine derivatives and their biological activities.
    M Kitahara, K Shinjyo, M Fukae, K Hosoe, T Shiraishi, K Ishii, K Watanabe, H Kawaharada
    We prepared new 7-hydroxyguanine derivatives, 7-hydroxyguanosine 5'-monophosphate and N2-tetrahydropyranyl-7-hydroxyguanine, and compared biological activities of 7-hydroxyguanine derivatives including nucleosides acquired previously. 7-Hydroxyguanine and its nucleotide inhibited the focus formation of Rous sarcoma virus. Antitumor activities of these derivatives against mouse leukemia L1210 were not so different from one another. Anti-proliferative activities of the derivatives on various human cell lines were significantly different from one another.
    Apr. 1990, The Journal of antibiotics, 43(4) (4), 352 - 6, English, Domestic magazine
    [Refereed]
    Scientific journal

  • MRI of mediastinal cavernous hemangioma.
    K Ishii, K Maeda, M Hashihira, Y Miyamoto, K Kanegawa, M Kusumoto, M Kono, S Nishiyama
    A cavernous hemangioma of the anterior mediastinum was studied by CT and MRI. CT did not give the diagnosis of the vascular tumor but MRI demonstrated the morphology of the vascular tumor. MRI is very useful for detecting a vascular tumor in the mediastinum.
    1990, Pediatric radiology, 20(7) (7), 556 - 7, English, International magazine
    [Refereed]
    Scientific journal

  • A case of tracheal agenesis
    K. Ishii, M. Hasegawa, T. Muraji, C. Tsugawa, K. Hashimoto, K. Kanegawa, S. Nishiyama, M. Kohno
    1989, Japanese Journal of Clinical Radiology, 34(1) (1), 161 - 163, Japanese
    [Refereed]
    Scientific journal

  • A case report of intralobar multifocal nephroblastomatosis
    K. Ishii
    1988, Japanese Journal of Clinical Radiology, 33(8) (8), 939 - 942, Japanese
    [Refereed]
    Scientific journal

  • A case of mesenchymal hamartoma of the liver
    K. Kanegawa, S. Nishiyama, M. Kono, H. Ito, K. Ishii, T. Tsugawa, K. Hashimoto, C. Sugimura
    1988, Japanese Journal of Clinical Radiology, 33(9) (9), 1035 - 1038, Japanese
    [Refereed]
    Scientific journal

■ MISC
  • 頭部・乳房専用PETが有用であった中枢神経系原発悪性リンパ腫の一例
    甲斐田勇人, 甲斐田勇人, 花岡宏平, 山田穣, 山田穣, 任誠雲, 山田誉大, 小路田泰之, 吉岡宏真, 奥田武司, 石井一成, 石井一成
    2024, 核医学(Web), 61(1) (1)

  • 神経膠腫のmethionine集積と病理分子遺伝学的因子との相関
    甲斐田勇人, 甲斐田勇人, 奥田武司, 河原明彦, 花岡宏平, 山田誉大, 泉本修一, 服部聡, 伊藤彰彦, 石井一成, 石井一成
    2024, 核医学(Web), 61(Supplement) (Supplement)

  • メチオニンPET/CTのvolumetric parameterによるIDH-wild type神経膠芽腫の予後評価
    甲斐田勇人, 甲斐田勇人, 奥田武司, 河原明彦, 花岡宏平, 山田誉大, 山田穣, 山田穣, 任誠雲, 泉本修一, 伊藤彰彦, 服部聡, 石井一成, 石井一成
    2024, 日本医学放射線学会秋季臨床大会抄録集, 60th

  • MRI拡散強調画像で眼虚血が示唆された2例
    平川真由美, 河野淳, 浦瀬篤史, 佐藤朋子, 平山歩, 谷龍一郎, 松久保祐子, 山田穣, 任誠雲, 岩橋千春, 岡田卓也, 兵頭朋子, 甲斐田勇人, 杉本幸司, 石井一成
    2024, 日本医学放射線学会秋季臨床大会抄録集, 60th

  • 地域在住非認知症高齢者における脈絡叢体積と認知機能との関連性
    日高洋介, 橋本衛, 末廣聖, 福原竜治, 石川智久, 津野田尚子, 梶谷直人, 朴秀賢, 石井一成, 池田学, 竹林実
    2024, 日本神経精神医学会学術集会プログラム・抄録集, 29th (CD-ROM)

  • 脳定位照射において異なる線量計算アルゴリズムの精度評価
    阪本 貴博, 松本 賢治, 大塚 正和, 南部 秀和, 松尾 幸憲, 石井 一成
    (公社)日本放射線技術学会, Sep. 2023, 日本放射線技術学会雑誌, 79(9) (9), 1073 - 1073, Japanese

  • 地域在住高齢者における脳脊髄液体積変化と認知機能障害との関連 熊本県荒尾市研究
    日高 洋介, 橋本 衛, 末廣 聖, 福原 竜治, 石川 智久, 津野田 尚子, 小山 明日香, 本田 和揮, 宮川 雄介, 吉浦 和宏, 朴 秀賢, 石井 一成, 池田 学, 竹林 実
    (公社)日本精神神経学会, Jun. 2023, 精神神経学雑誌, 119th(2023特別号) (2023特別号), S562 - S562, Japanese

  • T1・T2マッピングを用いたクローン病の疾患活動性評価
    石川 大介, 兵頭 朋子, 米田 頼晃, 上田 優, 福島 弘之, 齋藤 茂芳, 石井 一成
    (公社)日本放射線技術学会, Mar. 2023, 日本放射線技術学会総会学術大会予稿集, 79回, 202 - 202, Japanese

  • 3次元乳腺密度を指標としたU-netの乳腺領域自動抽出精度の評価
    山室美佳, 山室美佳, 浅井義行, 橋本直美, 安田奈生, 木村浩都, 任誠雲, 石井一成, 山田誉大, 根本充貴, 木村裕一, 吉田久, 半田久志, 近藤世範
    2022, 日本乳癌検診学会学術総会(CD-ROM), 32nd

  • 画素異常検知と深層教師なし特徴抽出によるFDG-PET/CT像上がん骨転移検出
    山口明乃, 根本充貴, 甲斐田勇人, 甲斐田勇人, 木村裕一, 永岡隆, 山田誉大, 花岡宏平, 北島一宏, 槌谷達也, 石井一成, 石井一成
    2022, 日本生体医工学会大会プログラム・抄録集(Web), 61st

  • 深層画像生成技術を用いたFDG-PET/CT像異常検知による病変強調
    瀬川新, 根本充貴, 甲斐田勇人, 甲斐田勇人, 山口明乃, 木村裕一, 永岡隆, 山田誉大, 北島一宏, 石井一成, 石井一成
    2022, 日本生体医工学会大会プログラム・抄録集(Web), 61st

  • Native T1マッピングによる潰瘍性大腸炎の疾患活動性評価の初期検討
    石川大介, 石川大介, 兵頭朋子, 米田頼晃, 上田優, 宮越敬三, 齋藤茂芳, 石井一成
    2022, 日本放射線技術学会総会学術大会予稿集, 78th

  • 11C-methonine PET/CTで高集積を認めた傍鞍部炎症性肉芽腫の一例
    甲斐田勇人, 甲斐田勇人, 奥田武司, 山田穣, 山田穣, 関紳一郎, 松久保祐子, 松久保祐子, 任誠雲, 花岡宏平, 山田誉大, 兵頭朋子, 鶴崎正勝, 細野眞, 細野眞, 石井一成, 石井一成
    2021, 核医学(Web), 58(1) (1)

  • 頭部CT AngiographyにおけるConvolutional Neural Networkを利用した新たなBolus Tracking法の考案
    渡邊翔太, 渡邊翔太, 坂口健太, 村田大輔, 山田浩司, 石井一成
    2021, 日本放射線技術学会総会学術大会予稿集, 77th

  • Development of a temporal image processing technique for brain 4DCT : combined use of temporal averaging and temporal maximum intensity projection depending on contrast enhancement
    渡邊翔太, 坂口健太, 村田大輔, 石井一成
    2021, 日本CT技術学会雑誌(Web), 9(1) (1)

  • Quantitative validation on PET image generator using CycleGAN for CAD to dementia
    渡邉綾, 山田誉大, 渡辺翔吾, 永岡隆, 根本充貴, 宮崎晃一, 花岡宏平, 甲斐田勇人, 甲斐田勇人, 石井一成, 石井一成, 木村裕一
    2021, 日本生体医工学会大会プログラム・抄録集(Web), 60th

  • Detection of bone metastasis on FDG-PET / CT image using cascade by two types of anomaly detections
    山口明乃, 根本充貴, 甲斐田勇人, 甲斐田勇人, 木村裕一, 永岡隆, 山田誉大, 花岡宏平, 北島一宏, 槌谷達也, 石井一成, 石井一成
    2021, 日本生体医工学会大会プログラム・抄録集(Web), 60th

  • 2種類の異常検知を用いたFDG-PET/CT像上のがん骨転移病変自動検出
    山口明乃, 根本充貴, 甲斐田勇人, 甲斐田勇人, 木村裕一, 永岡隆, 山田誉大, 花岡宏平, 北島一宏, 槌谷達也, 石井一成, 石井一成
    2021, 核医学(Web), 58(Supplement) (Supplement)

  • 敵対的生成ネットワークで合成したPET画像における定量性の検討
    渡邉綾, 木村裕一, 山田誉大, 渡辺翔吾, 永岡隆, 根本充貴, 宮崎晃一, 花岡宏平, 甲斐田勇人, 甲斐田勇人, 石井一成, 石井一成
    2021, 核医学(Web), 58(Supplement) (Supplement)

  • A Method for Measuring the Curative Effects of Molecular Targeted Therapy for Hepatocellular Carcinoma Using CT Images
    JOHNSON Joejeff, 阿部孝司, 波部斉, 兵頭朋子, 石井一成
    2021, 電気学会電子・情報・システム部門大会(Web), 2021

  • Development of KindAI-COVID, a diagnostic support system for COVID pneumonia using CT images
    永岡隆, 小塚健倫, 根本充貴, 波部斉, 山田誉大, 吉田久, 木村裕一, 石井一成
    2021, 日本生体医工学会大会プログラム・抄録集(Web), 60th

  • A. Tanaka, M. Nemoto, H. Kaida, Y. Kimura, T. Nagaoka, T. Yamada, K. Ushifusa, K. Hanaoka, K. Kitajima, T. Tsuchitani, K. Ishii
    Springer Science and Business Media LLC, Jun. 2020, International Journal of Computer Assisted Radiology and Surgery, 15(S1) (S1), 208 - 209, English
    [Refereed]
    Introduction international proceedings

  • 真性腸石のCT所見
    浜川 岳文, 松木 充, 鈴木 絢子, 沼本 勲男, 小田 晃義, 門場 智也, 細野 眞, 石井 一成
    (公社)日本医学放射線学会, Feb. 2020, Japanese Journal of Radiology, 38(Suppl.) (Suppl.), 42 - 42, Japanese

  • 横行結腸に生じたバンドによる絞扼性イレウスの1例 横行結腸軸捻転との比較
    沼本 勲男, 松木 充, 土居 秀平, 鈴木 絢子, 小田 晃義, 門場 智也, 藤谷 哲也, 松久保 祐子, 山田 穣, 兵頭 朋子, 任 誠雲, 甲斐田 勇人, 柳生 行伸, 小塚 健倫, 柏木 伸夫, 鶴崎 正勝, 細野 眞, 石井 一成
    (公社)日本医学放射線学会, Feb. 2020, Japanese Journal of Radiology, 38(Suppl.) (Suppl.), 42 - 42, Japanese

  • 梗塞性耳下腺腫瘍のMRI所見
    柏木 伸夫, 石井 一成, 小塚 健倫, 任 誠雲, 松木 充, 細野 眞
    (公社)日本医学放射線学会, Feb. 2020, Japanese Journal of Radiology, 38(Suppl.) (Suppl.), 45 - 45, Japanese

  • One-class SVMを用いた病変強調によるFDG-PET/CT上の頸胸部病変の自動検出
    田中敦子, 根本充貴, 甲斐田勇人, 木村裕一, 永岡隆, 山田誉大, 牛房和之, 花岡宏平, 北島一宏, 槌谷達也, 石井一成, 石井一成
    2020, 電子情報通信学会技術研究報告, 119(399(MI2019 65-123)(Web)) (399(MI2019 65-123)(Web))

  • 認知症自動診断AIアルゴリズム学習のための深層学習により加増したアミロイド画像の検証
    渡邉綾, 木村裕一, 山田誉大, 渡辺翔吾, 永岡隆, 根本充貴, 宮崎晃一, 花岡宏平, 甲斐田勇人, 甲斐田勇人, 石井一成, 石井一成
    2020, 核医学(Web), 57(Supplement) (Supplement)

  • One-class SVMを用いた異常検知によるPET/CT上の骨転移病変自動検出
    田中敦子, 根本充貴, 甲斐田勇人, 甲斐田勇人, 木村裕一, 永岡隆, 牛房和之, 山田誉大, 花岡宏平, 北島一宏, 槌谷達也, 石井一成, 石井一成
    2020, 核医学(Web), 57(Supplement) (Supplement)

  • Deep learningを用いた非高濃度乳房に対する乳腺領域の自動抽出
    山室美佳, 山室美佳, 浅井義行, 橋本直美, 安田奈生, 尾崎吉明, 任誠雲, 石井一成, 山田誉大, 根本充貴, 木村裕一, 吉田久, 半田久志, 李鎔範
    2020, 日本乳癌検診学会学術総会プログラム抄録集, 30th (CD-ROM)

  • Deep learning segmentationでの複数の放射線技師による教師データ作成の有用性
    山室美佳, 山室美佳, 浅井義行, 橋本直美, 安田奈生, 尾崎吉明, 任誠雲, 石井一成, 山田誉大, 根本充貴, 木村祐一, 吉田久, 半田久志, 李鎔範
    2020, 日本乳癌検診学会学術総会プログラム抄録集, 30th (CD-ROM)

  • 【認知症の画像診断〜ルーチン検査から最新の画像検査まで〜】特発性正常圧水頭症の画像診断
    宮崎 晃一, 石井 一成
    (株)メディカルアイ, Oct. 2019, Rad Fan, 17(13) (13), 35 - 40, Japanese

  • 門場 智也, 松木 充, 若菜 みゆき, 鈴木 絢子, 浜川 岳文, 小田 晃義, 沼本 勲男, 松久保 祐子, 任 誠雲, 柳生 行伸, 小塚 健倫, 鶴崎 正勝, 石井 一成
    (株)学研メディカル秀潤社, Sep. 2019, 画像診断, 39(12) (12), 1257 - 1275, Japanese

  • 経皮的ルートからの良性胆道狭窄に対するプラスチックステント留置術の初期経験
    小田 晃義, 鶴崎 正勝, 鈴木 絢子, 土居 秀平, 沼本 勲男, 門場 智也, 柳生 行伸, 柏木 伸夫, 石井 一成
    (一社)日本インターベンショナルラジオロジー学会, Sep. 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(1) (1), 79 - 79, Japanese

  • 核医学によるてんかん画像診断
    石井 一成
    (一社)日本てんかん学会, Sep. 2019, てんかん研究, 37(2) (2), 473 - 473, Japanese

  • 肝細胞癌術後胆汁瘻に対し経皮的アプローチと内視鏡的アプローチを組み合わせてステント留置を施行した1例
    鈴木 絢子, 沼本 勲男, 鶴崎 正勝, 小田 晃義, 門場 智也, 柳生 行伸, 石井 一成, 岡本 彩那, 三長 孝輔, 岩崎 寿光
    (一社)日本インターベンショナルラジオロジー学会, Sep. 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(1) (1), 79 - 79, Japanese

  • FDG-PET and amyloid PET for clinical diagnosis of dementia
    石井 一成
    医歯薬出版(株), Aug. 2019, 医学のあゆみ, 270(9) (9), 725 - 731, Japanese

  • Nuclear protein in testis(NUT)midline carcinomaの一例
    山田 穣, 柏木 伸夫, 土居 秀平, 沼本 勲男, 浜川 岳文, 門場 智也, 松久保 祐子, 兵頭 朋子, 甲斐田 勇人, 任 誠雲, 柳生 行伸, 小塚 健倫, 岡野 意浩, 坂田 尚己, 松木 充, 石井 一成
    (一社)日本小児放射線学会, Jun. 2019, 日本小児放射線学会雑誌, 35(Suppl.) (Suppl.), 28 - 28, Japanese

  • Evaluation of Robustness in Computer-Aided Diagnosis for Parkinsonian Syndromes Based on Machine Learning with Multi-center DaTSCAN SPECT Images
    渡辺 翔吾, 杉本 直三, 木村 裕一, 根本 充貴, 石井 一成, 三品 雅洋
    システム制御情報学会, 22 May 2019, システム制御情報学会研究発表講演会講演論文集, 63, 453 - 455, Japanese

  • 肝細胞癌破裂症例の予後因子に関する臨床的検討
    鈴木 絢子, 鶴崎 正勝, 沼本 勲男, 小田 晃義, 門場 智也, 柳生 行伸, 石井 一成
    (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 229 - 229, Japanese

  • iNPH Diagnostic imaging DESH
    石井 一成
    (株)メディカルアイ, Mar. 2019, Rad Fan, 17(4) (4), 5 - 9, Japanese

  • 筋腫分娩様の所見を呈し,術前診断が困難であった子宮平滑筋肉腫の1例
    犬養純子, 浦瀬靖代, 神田知紀, 上野嘉子, 田中宇多留, 祖父江慶太郎, 前田隆樹, 野上宗伸, 松本培世, 蝦名康彦, 寺井義人, 原重雄, 今岡いずみ, 石井一成, 村上卓道
    2019, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 20th

  • 認知症自動診断AIアルゴリズム学習のための深層学習によるアミロイド画像の加増手法の検討
    渡邉綾, 山田誉大, 永岡隆, 根本充貴, 花岡宏平, 甲斐田勇人, 石井一成, 石井一成, 木村裕一
    2019, 核医学(Web), 56(Supplement) (Supplement)

  • AI異常検知に基づくPET/CT上の頸胸部病変の自動認識
    田中敦子, 根本充貴, 甲斐田勇人, 甲斐田勇人, 木村裕一, 山田誉大, 牛房和之, 花岡宏平, 北島一宏, 槌谷達也, 石井一成, 石井一成
    2019, 核医学(Web), 56(Supplement) (Supplement)

  • 田中 敦子, 根本 充貴, 甲斐田 勇人, 木村 裕一, 永岡 隆, 山田 誉大, 花岡 宏平, 石井 一成

    【目的】臨床的価値の高いFDG-PET/CT画像診断における医師の負担軽減及び診断精度向上のため、FDG-PET/CTの画像パターンに対する異常検知処理に基づく頸胸部病変の自動検出法を提案する。【手法】FDG-PETは、糖代謝亢進を反映し腫瘍部位では異常集積を呈する。そこで提案法では、CTの閾値処理及びモルフォロジ処理にて左右肺野を自動抽出し、肺野を基準に縦隔領域を自動抽出する。次に領域ごとの健常組織画素値に関する統計モデルを用いた異常検知による病変候補の検出を行う。異常検知に用いる統計モデルは健常画像の画素(HU, SUV)の2次元正規分布モデルとし、マハラノビス距離を異常度として計測する。左肺、右肺、縦隔で個別に算出した異常度の閾値処理にて病変候補を得る。得られた候補領域から微小体積のものを削除し、腫瘍が疑われる部位を検出する。図に病変検出例を示す。【結果】臨床撮像された食道癌、肺癌の10症例の全身PET/CTを用いて提案法の評価実験を行ったところ、検出感度94.7%(18/19病変)、過検出数14.0個/例の性能が得られ、提案法の有用性を確認した。【結論】今後の課題は、病変検出感度の改善や誤検出病変候補の削減処理の追加が挙げられる。

    公益社団法人 日本生体医工学会, 2019, 生体医工学, 57(0) (0), S249_2 - S249_2, Japanese

  • イメージングバイオマーカー(structural MRI,FDG‐PET,PiB PET)を用いた軽度認知障害からアルツハイマー型認知症への進展予測
    岡田佑介, 岡田佑介, 岩田香織, 加藤隆司, 木村泰之, 木澤剛, 中村昭範, 服部英幸, 乾好貴, 外山宏, 石井一成, 石井賢二, 千田道雄, 松田博史, 伊藤健吾, 岩坪威
    (一社)日本核医学会, Dec. 2018, 核医学(Web), 55(1) (1), 14(J‐STAGE) - 14, Japanese

  • Morphologic imaging for mild cognitive impairment
    石井 一成
    (株)アークメディア, Dec. 2018, 臨床精神医学, 47(12) (12), 1385 - 1389, Japanese

  • パーキンソン症候群に対するDAT Z-score画像の臨床応用
    高橋 竜一, 石井 一成, 樫林 哲雄, 丸本 浩平, 多々野 誠, 水田 英二
    (一社)日本神経学会, Dec. 2018, 臨床神経学, 58(Suppl.) (Suppl.), S213 - S213, Japanese

  • 岡田 佑介, 岩田 香織, 加藤 隆司, 木村 泰之, 木澤 剛, 中村 昭範, 服部 英幸, 乾 好貴, 外山 宏, 石井 一成, 石井 賢二, 千田 道雄, 松田 博史, 伊藤 健吾, 岩坪 威
    (一社)日本核医学会, Dec. 2018, 核医学, 55(1) (1), 14 - 14, Japanese

  • 胸骨圧迫による遅発性両側内胸動脈出血に対し、経カテーテル的動脈塞栓術を施行した1例
    鈴木 絢子, 鶴崎 正勝, 小田 晃義, 沼本 勲男, 門場 智也, 柳生 行伸, 土居 秀平, 柏木 伸夫, 石井 一成
    (一社)日本インターベンショナルラジオロジー学会, Nov. 2018, IVR: Interventional Radiology, 33(3) (3), 315 - 315, Japanese

  • 肝門部胆管癌における胆道再建後の吻合部再発に対し胆管および門脈にステント留置術を行った2例
    門場 智也, 鶴崎 正勝, 小田 晃義, 沼本 勲男, 柳生 行伸, 柏木 伸夫, 石井 一成, 鎌田 研, 工藤 正俊
    (一社)日本インターベンショナルラジオロジー学会, Nov. 2018, IVR: Interventional Radiology, 33(3) (3), 318 - 318, Japanese

  • PiB PETの境界的な集積に対応する皮質平均SUVRのカットオフ値の検討
    岡田 佑介, 岩田 香織, 加藤 隆司, 服部 英幸, 外山 宏, 石井 一成, 石井 賢二, 千田 道雄, 伊藤 健吾, 岩坪 威, Neuroimaging Initiative Japanese Alzheimer's Disease
    (一社)日本核医学会, Nov. 2018, 核医学, 55(Suppl.) (Suppl.), S169 - S169, Japanese

  • 【認知症トータルケア】アルツハイマー型認知症のCT、MRI画像、脳血流SPECT、アミロイドPET
    石井 一成
    (公社)日本医師会, Oct. 2018, 日本医師会雑誌, 147(特別2) (特別2), S4 - S6, Japanese

  • 脳血流SPECT検査 (特集 鑑別診断に用いられる脳イメージング)
    高橋 竜一, 石井 一成
    フジメディカル出版, Oct. 2018, 認知症の最新医療 : 認知症医療の今を伝える専門誌, 8(4) (4), 171 - 176, Japanese

  • 頭頸部扁平上皮癌からの骨転移
    鈴木 絢子, 柏木 伸夫, 沼本 勲男, 小田 晃義, 門場 智也, 兵頭 朋子, 山田 穣, 甲斐田 勇人, 柳生 行伸, 任 誠雲, 鶴崎 正勝, 小塚 健倫, 松木 充, 石井 一成, 中西 克之
    (公社)日本医学放射線学会, Sep. 2018, 日本医学放射線学会秋季臨床大会抄録集, 54回, S470 - S470, Japanese

  • 真性腸石のCT所見
    浜川 岳文, 松木 充, 鈴木 絢子, 沼本 勲男, 小田 晃義, 門場 智也, 土居 秀平, 松久保 祐子, 兵頭 朋子, 任 誠雲, 甲斐田 勇人, 柳生 行伸, 鶴崎 正勝, 小塚 健倫, 石井 一成
    (公社)日本医学放射線学会, Sep. 2018, 日本医学放射線学会秋季臨床大会抄録集, 54回, S498 - S498, Japanese

  • 非外傷性急性硬膜下血腫の画像診断
    沼本 勲男, 松木 充, 土居 秀平, 鈴木 絢子, 小田 晃義, 門場 智也, 松久保 裕子, 兵頭 朋子, 任 誠雲, 柏木 伸夫, 小塚 健倫, 鶴崎 正勝, 石井 一成
    (公社)日本医学放射線学会, Sep. 2018, 日本医学放射線学会秋季臨床大会抄録集, 54回, S502 - S503, Japanese

  • 拡張した右下横隔膜動脈の破綻によって発症した血胸の1例
    小田 晃義, 松木 充, 鶴崎 正勝, 沼本 勲男, 門場 智也, 柳生 行信, 小塚 健倫, 石井 一成
    (公社)日本医学放射線学会, Sep. 2018, 日本医学放射線学会秋季臨床大会抄録集, 54回, S548 - S548, Japanese

  • Diagnostic imaging for dementia : Difficulty of standardization
    石井 一成
    (株)ワールドプランニング, Sep. 2018, 老年精神医学雑誌, 29(9) (9), 931 - 939, Japanese

  • PiB PETの境界的な集積に対応する皮質平均SUVRのカットオフ値の検討
    岡田 佑介, 岩田 香織, 加藤 隆司, 木村 泰之, 中村 昭範, 服部 英幸, 外山 宏, 石井 一成, 石井 賢二, 千田 道雄, 伊藤 健吾, 岩坪 威
    (一社)日本認知症学会, Sep. 2018, Dementia Japan, 32(3) (3), 470 - 470, Japanese

  • 脳内アミロイドβ蓄積を反映する血液バイオマーカー 多施設共同研究による精度の検討
    中村 昭範, 金子 直樹, 加藤 隆司, 石井 賢二, 石井 一成, 新畑 豊, 岩本 慎一, 伊藤 健吾, 田中 耕一, 柳澤 勝彦
    (一社)日本認知症学会, Sep. 2018, Dementia Japan, 32(3) (3), 418 - 418, Japanese

  • バッドキアリ症候群に伴う急性肝不全に対して肝移植までのbridging therapyとしてTIPSを施行した一例
    沼本勲男, 鶴崎正勝, 鈴木絢子, 土居秀平, 小田晃義, 門馬智也, 柳生行伸, 石井一成, 上嶋一臣, 工藤正俊
    (一社)日本門脈圧亢進症学会, 24 Aug. 2018, 日本門脈圧亢進症学会雑誌, 24(3) (3), 136 - 136, Japanese

  • バッドキアリ症候群に伴う急性肝不全に対して肝移植までのbridging therapyとしてTIPSを施行した一例
    沼本 勲男, 鶴崎 正勝, 鈴木 絢子, 土居 秀平, 小田 晃義, 門馬 智也, 柳生 行伸, 石井 一成, 上嶋 一臣, 工藤 正俊
    (一社)日本門脈圧亢進症学会, Aug. 2018, 日本門脈圧亢進症学会雑誌, 24(3) (3), 136 - 136, Japanese

  • 石井 一成
    (株)学研メディカル秀潤社, Jul. 2018, 画像診断, 38(9) (9), 929 - 937, Japanese

  • Diagnostic Imaging for Dementia with Lewy Bodies
    石井 一成
    近畿大学医学会, Jun. 2018, 近畿大学医学雑誌, 43(1-2) (1-2), 3 - 10, Japanese

  • 脳脊髄液 特発性正常圧水頭症の画像所見
    石井 一成
    日本画像医学会, Feb. 2018, Japanese Journal of Diagnostic Imaging, 36(1) (1), 72 - 72, Japanese

  • 石井 一成
    (株)学研メディカル秀潤社, Feb. 2018, 画像診断, 38(3) (3), 297 - 304, Japanese

  • 【認知症と画像診断-認知症の画像診断の役割と将来展望-】画像診断 FDG-PETの役割
    石井 一成
    (株)メディカルアイ, Feb. 2018, Rad Fan, 16(3) (3), 71 - 73, Japanese

  • Brain FDG-PET and perfusion SPECT for dementia
    石井 一成
    金原出版(株), Feb. 2018, 臨床放射線, 63(2) (2), 151 - 156, Japanese

  • AI異常検知を用いたFDG-PET/CT上の頸胸部原発性・転移性病変の検出
    根本充貴, 甲斐田勇人, 田中敦子, 牛房和之, 山田誉大, 木村裕一, 花岡宏平, 石井一成, 石井一成
    2018, 核医学(Web), 55(Supplement) (Supplement)

  • SRTM法を用いたアミロイドイメージングに対する空間分解能を損なわないノイズ低減アルゴリズムの検討
    山田誉大, 木村裕一, 根本充貴, 坂田宗之, 永岡隆, 花岡宏平, 甲斐田勇人, 石井一成, 石井一成
    2018, 核医学(Web), 55(Supplement) (Supplement)

  • 【実施診療のための最新認知症学-検査・治療・予防・支援-】アルツハイマー病の先進医療とRegistry DIAN-J研究登録事業
    森 啓, 嶋田 裕之, 東海林 幹夫, 池内 健, 鈴木 一詩, 千田 道雄, 石井 賢二, 松田 博史, 岩田 敦, 井原 涼子, 岩坪 威, 武藤 香織, 中澤 栄輔, 関島 良樹, 森 悦朗, 池田 学, 池田 将樹, 川勝 忍, 中西 亜紀, 橋本 衛, 布村 明彦, 松原 悦朗, 福井 充, 白戸 朋代, 平井 香織, 坂本 昌子, 藤井 比佐子, 石井 一成, 西郷 和真
    (株)日本臨床社, Jan. 2018, 日本臨床, 76(増刊1 実施診療のための最新認知症学 検査・治療・予防・支援) (増刊1 実施診療のための最新認知症学 検査・治療・予防・支援), 258 - 265, Japanese

  • Yamada Takahiro, Kimura Yuichi, Fujii kosuke, Watanabe Shogo, Nagaoka Takashi, Nemoto Mitsutaka, Hanaoka Kohei, Kaida Hayato, Ishii Kazunari

    This study aims to develop a noise reduction algorithm for amyloid PET imaging. A visualization of a small amyloid-β (Aβ) deposit is required for early diagnosis of Alzheimer's disease (AD) pathology, and a noise in amyloid image should be reduced without any loss of spatial resolution. Conventional noise reduction algorithms use spatial averaging, but our proposed algorithm, CAKS, averages pixels that have similar kinetics of administered PET radiopharmaceutical. As a result of CAKS applying to actual clinical images, the noise is reduced and the image quality is improved. The contrast between gray and white matters is significantly improved (p<.05). We concluded that CAKS is applied to clinical amyloid PET imaging is useful for diagnosis of AD pathology.

    Japanese Society for Medical and Biological Engineering, 2018, Transactions of Japanese Society for Medical and Biological Engineering, 56(0) (0), S294 - S294, Japanese

  • 18F-FDG PETによる軽度認知障害からアルツハイマー型認知症への進展予測
    岡田 佑介, 岩田 香織, 加藤 隆司, 木村 泰之, 木澤 剛, 中村 昭範, 服部 英幸, 乾 好貴, 外山 宏, 石井 一成, 石井 賢二, 千田 道雄, 松田 博史, 伊藤 健吾, 岩坪 威, J-ADNI研究グループ
    (一社)日本認知症学会, Oct. 2017, Dementia Japan, 31(4) (4), 606 - 606, Japanese

  • 進行性核上性麻痺と診断された進行性非流暢性失語症の一例
    高月 容子, 嶋田 兼一, 石井 一成, 寺島 明
    日本神経心理学会, Sep. 2017, 日本神経心理学会総会プログラム・予稿集, 41回, 91 - 91, Japanese

  • Volumetric parameterを用いた食道癌切除患者の予後因子の検討
    甲斐田 勇人, 石井 一成, 細川 知紗, 柳生 行伸, 任 誠雲, 兵頭 朋子, 山田 穣, 細野 眞, 安田 卓司, 村上 卓道
    (一社)日本核医学会, Sep. 2017, 核医学, 54(Suppl.) (Suppl.), S193 - S193, Japanese

  • 健忘型MCI患者におけるアパシーの脳内基盤
    山本 諭希, 数井 裕光, 高橋 竜一, 吉山 顕次, 鐘本 英輝, 鈴木 由希子, 佐藤 俊介, 東 眞吾, 末廣 聖, 下瀬川 恵久, 石井 一成, 田中 稔久, 池田 学
    日本神経心理学会, Sep. 2017, 日本神経心理学会総会プログラム・予稿集, 41回, 137 - 137, Japanese

  • 動態に基づいたアミロイドイメージング雑音除去アルゴリズムの性能評価
    山田 誉大, 木村 裕一, 藤井 康介, 渡辺 翔吾, 永岡 隆, 花岡 宏平, 細川 知紗, 石井 一成, 村上 卓道
    (一社)日本核医学会, Sep. 2017, 核医学, 54(Suppl.) (Suppl.), S210 - S210, Japanese

  • 全身FDG PET/CT撮像において収集時間と画像再構成方法が定量性および画質に与える影響
    柴田 侑亮, 花岡 宏平, 渡邊 翔太, 奥村 雅彦, 石井 一成
    (公社)日本放射線技術学会, Sep. 2017, 日本放射線技術学会雑誌, 73(9) (9), 895 - 895, Japanese

  • 呼吸同期FDG PET/CTによる放射線治療計画について
    花岡 宏平, 奥村 雅彦, 西村 泰昌, 門前 一, 渡邊 翔太, 柴田 侑亮, 細野 眞, 石井 一成, 村上 卓道
    (一社)日本核医学会, Sep. 2017, 核医学, 54(Suppl.) (Suppl.), S167 - S167, Japanese

  • 動態に基づいたアミロイドイメージング雑音除去アルゴリズムの性能評価
    山田 誉大, 木村 裕一, 藤井 康介, 渡辺 翔吾, 永岡 隆, 花岡 宏平, 細川 知紗, 石井 一成, 村上 卓道
    (一社)日本核医学会, Sep. 2017, 核医学, 54(Suppl.) (Suppl.), S210 - S210, Japanese

  • 呼吸同期FDG PET/CTによる放射線治療計画について
    花岡 宏平, 奥村 雅彦, 西村 泰昌, 門前 一, 渡邊 翔太, 柴田 侑亮, 細野 眞, 石井 一成, 村上 卓道
    (一社)日本核医学会, Sep. 2017, 核医学, 54(Suppl.) (Suppl.), S167 - S167, Japanese

  • 認知症の画像診断Up to date 認知症のSPECT/PET診断 FDG-PETの保険適応に向けて
    石井 一成
    (公社)日本医学放射線学会, Aug. 2017, 日本医学放射線学会秋季臨床大会抄録集, 53回, S382 - S383, Japanese

  • 岡田 佑介, 岩田 香織, 加藤 隆司, 木村 泰之, 木澤 剛, 中村 昭範, 服部 英幸, 乾 好貴, 外山 宏, 石井 一成, 石井 賢二, 千田 道雄, 伊藤 健吾, 岩坪 威, J-ADNI Group
    (株)ワールドプランニング, Jun. 2017, 老年精神医学雑誌, 28(増刊II) (増刊II), 168 - 168, Japanese

  • ISHII Kazunari
    The CAD system in the field of the brain nuclear medicine has been developed for diagnosis of dementia. The technique using voxel-based statistical analysis system has been developed and is used in the clinical study for brain glucose metabolic PET images and perfusion SPECT images. There may be few artifacts on the analysis process and it is always necessary to compare the findings with visual inspections. These methods have not yet established the evidence of good diagnostic performances. These techniques are expected to have high diagnostic accuracy and to be applied to other brain images: amino acid metabolic images, brain receptor images and amyloid images.
    The Japanese Society of Medical Imaging Technology, May 2017, Medical Imaging Technology, 35(3) (3), 129 - 133, Japanese

  • Integrated FDG-PET/MRI for whole-body staging in patients with recurrent gynecological cancer
    Kazuhiro Kitajima, Munenobu Nogami, Satoru Takahashi, Yoshiko Ueno, Yasuhiko Ebina, Kazuhiro Kubo, Utaru Tanaka, Keitaro Sofue, Takeaki Ishihara, Yuichi Wakabayashi, Kazunari Ishii, Kazuro Sugimura
    May 2017, JOURNAL OF NUCLEAR MEDICINE, 58, English
    Summary international conference

  • Prognostic impact of F-18-FDG PET parameters and molecular markers expression in resected non-small cell lung cancer patients.
    Hayato Kaida, Koichi Azuma, Akihiko Kawahara, Eiji Sadashima, Satoshi Hattori, Jun Akiba, Axel Rominger, Shinzo Takamori, Kiminori Fujimoto, Makoto Hosono, Kazunari Ishii, Takamichi Murakami, Masatoshi Ishibashi
    May 2017, JOURNAL OF NUCLEAR MEDICINE, 58, English
    Summary international conference

  • 11C‐Pittsburgh Compound‐Bを用いたアミロイドイメージングにおいて画像再構成方法が半定量値へ与える影響
    渡邊翔太, 花岡宏平, 石井一成, 石井一成
    (公社)日本放射線技術学会, Mar. 2017, 日本放射線技術学会総会学術大会予稿集, 73回, 138 - 138, Japanese

  • 脳脊髄液 正常圧水頭症の画像所見
    石井 一成
    日本画像医学会, Feb. 2017, Japanese Journal of Diagnostic Imaging, 35(1) (1), 43 - 43, Japanese

  • 捻転を呈した漿膜下子宮筋腫の2例
    浜川 岳文, 松木 充, 沼本 勲男, 小田 晃義, 福井 秀行, 兵頭 朋子, 任 誠雲, 柳生 行伸, 今岡 いずみ, 鶴崎 正勝, 石井 一成, 村上 卓道
    日本画像医学会, Feb. 2017, Japanese Journal of Diagnostic Imaging, 35(1) (1), 96 - 96, Japanese

  • ANCA関連腎炎に合併した縦隔線維症の1例
    日高 正二朗, 小塚 健倫, 浜川 岳文, 福井 秀行, 渡口 真史, 山田 穣, 任 誠雲, 柏木 伸夫, 細川 知紗, 鶴崎 正勝, 今岡 いずみ, 松木 充, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2017, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 48 - 48, Japanese

  • 膀胱子宮内膜症の経過を追った2例
    沼本 勲男, 今岡 いずみ, 若林 雄一, 藤谷 哲也, 山川 美穂, 兵頭 朋子, 甲斐田 勇人, 柳生 行伸, 熊野 正士, 鶴崎 正勝, 松木 充, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2017, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 49 - 49, Japanese

  • 上顎洞術後変化としての眼窩下管拡大
    福井 秀行, 柏木 伸夫, 任 誠雲, 甲斐田 勇人, 柳生 行伸, 小塚 健倫, 細川 知紗, 熊野 正士, 鶴崎 正勝, 松木 充, 今岡 いずみ, 石井 一成, 細野 眞, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2017, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 54 - 54, Japanese

  • 甲斐田 勇人, 石井 一成, 細川 知紗, 仁 誠雲, 細野 眞, 村上 卓道, 花岡 宏平, 乾 浩己
    (一社)日本核医学会, Feb. 2017, 核医学, 54(1) (1), 668 - 669, Japanese

  • FDG-PET/CTで集積を認めた異所性甲状腺癌の一例
    甲斐田 勇人, 石井 一成, 細川 知紗, 仁 誠雲, 細野 眞, 村上 卓道, 花岡 宏平, 乾 浩己
    (一社)日本核医学会, Feb. 2017, 核医学, 54(1) (1), 668 - 669, Japanese

  • 脳血流SPECT定性画像上のConvexity“APPArent”Hyperperfusion(CAPPAH)signがiNPHの診断に有用である
    大道卓摩, 近藤正樹, 徳田隆彦, 徳田隆彦, 小泉英貴, 松島成典, 栗山長門, 石井一成, 森悦朗, 山田惠, 水野敏樹
    2017, 日本正常圧水頭症学会プログラム・抄録集, 18th

  • Yamada Takahiro, Kimura Yuichi, Nagaoka Takashi, Hanaoka Kohei, Hosokawa Chisa, Ishii Kazunari

    In Alzheimer's disease (AD) amyloid-β (Aβ) depositions disturbs neurons irreversibly, and early treatment before occurrence of dementia is important for AD treatments. This study aims at proposing an automated delineation algorithm for reference regions (AutoRef) for Aβ accumulation quantification. This presentation focuses on merits of a limited temporal information and the increased number clusters. As a result, for 86 clinical data (43 cases of AD, 33 cases of normal and 10 cases of equivocal deposition of Aβ), AutoRef succeeded in delineating the reference region for all the data. There was no significant difference (p < 0.05) between AutoRef and manually delineated reference region by a physician. The standard deviation of the difference between them was smaller than the discrimination threshold of AD used in actual clinical practice. In conclusions, the effectiveness of this study was suggested.

    Japanese Society for Medical and Biological Engineering, 2017, Transactions of Japanese Society for Medical and Biological Engineering, 55(4) (4), 281 - 281, Japanese

  • 脳血流SPECT 123I-IMP
    石井 一成
    (一社)日本核医学会, Oct. 2016, 核医学, 53(Suppl.) (Suppl.), S225 - S225, Japanese

  • 薬剤動態に基づいたアミロイドイメージングに対する雑音低減アルゴリズム
    木村 裕一, 藤井 康介, 山田 誉大, 細川 知紗, 坂田 宗之, 石井 一成, 村上 卓道
    (一社)日本核医学会, Oct. 2016, 核医学, 53(Suppl.) (Suppl.), S277 - S277, Japanese

  • 非小細胞肺癌のFDG集積とGlut-1、pStat-1、pStat-3での予後因子の検討
    甲斐田 勇人, 東 公一, 河原 明彦, 服部 聡, 倉田 精二, 高森 信三, 藤本 公則, 鹿毛 政義, 石井 一成, 村上 卓道, 石橋 正敏
    (一社)日本核医学会, Oct. 2016, 核医学, 53(Suppl.) (Suppl.), S283 - S283, Japanese

  • 認知症患者における線条体アミロイド沈着の検討
    細川 知紗, 石井 一成, Sauerbeck Julia, Sheiwein Franziska, 甲斐田 勇人, 兵頭 朋子, 山田 穣, 細野 眞, 花岡 宏平, 村上 卓道
    (一社)日本核医学会, Oct. 2016, 核医学, 53(Suppl.) (Suppl.), S276 - S276, Japanese

  • 逐次近似応用再構成法が超急性期脳梗塞CT画像におけるZスコアマッピングに与える影響
    渡邊 翔太, 坂口 健太, 細野 眞, 石井 一成, 村上 卓道, 市川 勝弘
    (公社)日本放射線技術学会, Sep. 2016, 日本放射線技術学会雑誌, 72(9) (9), 813 - 813, Japanese

  • 嶋田 兼一, 石井 一成, 小田 陽彦, 長谷川 玲子, 牧野 史織, 土井 亜里紗, 熊尾 良子, 寺島 明
    (株)ワールドプランニング, Jun. 2016, 老年精神医学雑誌, 27(増刊II) (増刊II), 189 - 189, Japanese

  • 石井 一成
    (NPO)日本核医学技術学会, Apr. 2016, 核医学技術, 36(2) (2), 142 - 143, Japanese

  • 上顎洞術後変化としての眼窩下管拡大
    福井 秀行, 柏木 伸夫, 任 誠雲, 甲斐田 勇人, 柳生 行伸, 小塚 健倫, 細川 知紗, 熊野 正士, 鶴崎 正勝, 松木 充, 今岡 いずみ, 細野 眞, 石井 一成, 村上 卓道
    日本画像医学会, Feb. 2016, Japanese Journal of Diagnostic Imaging, 34(1) (1), 116 - 116, Japanese

  • IgG4関連疾患によると思われる冠動脈病変の1例
    千葉 輝明, 松木 充, 今岡 いずみ, 熊野 正士, 小塚 健倫, 柏木 伸夫, 柳生 行伸, 足利 竜一朗, 鶴崎 正勝, 石井 一成, 村上 卓道, 平野 豊, 樋野 尚一
    (公社)日本医学放射線学会, Feb. 2016, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 55 - 55, Japanese

  • 当院における胃粘膜下腫瘍に対する18F-FDG PET検査
    沼本 勲男, 松木 充, 福井 秀行, 若林 雄一, 渡口 真史, 千葉 輝明, 山田 穣, 柏木 伸夫, 細川 知紗, 小塚 健倫, 細野 眞, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2016, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 56 - 56, Japanese

  • 脳神経系におけるPET画像診断
    石井 一成
    (公社)日本放射線技術学会, Feb. 2016, 日本放射線技術学会総会学術大会予稿集, 72回, 109 - 109, Japanese

  • 当院における大腸内視鏡不完全症例に対するCT colonographyの活用
    松木充, 朝戸信行, 山川美帆, 藤谷哲也, 任誠雲, 兵頭朋子, 柳生行伸, 鶴崎正勝, 熊野正士, 今岡いずみ, 足利竜一朗, 石井一成, 村上卓道
    (公社)日本医学放射線学会, Feb. 2016, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 57 - 57, Japanese

  • 細川 知紗, 石井 一成, Sauerbeck Julia, Scheiwein Franziska, 甲斐田 勇人, 山田 穣, 兵頭 朋子, 細野 眞, 花岡 宏平, 村上 卓道
    (一社)日本核医学会, Feb. 2016, 核医学, 53(1) (1), 561 - 561, Japanese

  • 薬剤動態に基づいたアミロイドイメージングに対する雑音低減アルゴリズム
    木村裕一, 藤井康介, 山田誉大, 細川知紗, 坂田宗之, 石井一成, 村上卓道
    2016, 核医学(Web), 53(Supplement) (Supplement)

  • Yamada Takahiro, Kimura Yuichi, Nagaoka Takashi, Okada Shima, Hosokawa Chisa, Ishii Kazunari

    A deposit of amyloid β (Aβ) to the central nervous system causes Alzheimer's disease (AD). A periodical evaluation on Aβ, a year, can therefor detect the beginning of AD, and it realizes an effective medical treatment for AD. For quantitative measurement of Aβ deposit is available using PET, and it requires to delineate the cerebellum gray matter as a reference region, when no Aβ deposit occurs physiologically and it has complicated shape. This study aim at proposing automated delineation algorithm based on a kinetics of administered PET tracer for Aβ imaging. The validation using a clinical data presented no significant difference (p < 0.05) between the amount of Aβ deposit using an ordinary manual delineation and the automated method. We can conclude that the algorithm is clinically useful.

    Japanese Society for Medical and Biological Engineering, 2016, Transactions of Japanese Society for Medical and Biological Engineering, 54(26) (26), S45 - S45, Japanese

  • 認知症患者における線条体アミロイド沈着の検討
    細川知紗, 石井一成, SAUERBECK Julia, SHEIWEIN Franziska, 甲斐田勇人, 兵頭朋子, 山田穣, 細野眞, 花岡宏平, 村上卓道
    2016, 核医学(Web), 53(Supplement) (Supplement), 1230(J‐STAGE), Japanese

  • 11C‐PiB PET陽性認知症の線条体集積の検討
    細川知紗, 石井一成, SAUERBECK Julia, SCHEIWEIN Franziska, 甲斐田勇人, 山田穣, 兵頭朋子, 細野眞, 花岡宏平, 村上卓道
    2016, 核医学(Web), 53(1) (1), 561(J‐STAGE), Japanese

  • 単体ソフト薬事関連情報
    石井 一成
    日本メジフィジックス(株), Dec. 2015, ブレイン・ファンクション・イメージング・カンファレンス記録集, (31) (31), 5 - 5, Japanese

  • 石井 一成
    (株)インナービジョン, Nov. 2015, INNERVISION, 30(12) (12), 56 - 57, Japanese

  • 甲斐田 勇人, 石井 一成, 村上 卓道, 田原 宣広, 本多 亮博, 福本 義弘, 石橋 正敏
    (一社)日本核医学会, Nov. 2015, 核医学, 52(4) (4), 403 - 403, Japanese

  • The correlation between 18F-FDG uptake and Glut-1, Stat-1 and Stat-3 in non-small cell lung cancer patients.
    H. Kaida, K. Azuma, A. Kawahara, S. Hattori, S. Takamori, E. Sadashima, K. Fujimoto, M. Kage, S. Kurata, Y. Hirose, K. Ishii, T. Murakami, M. Ishibashi
    Oct. 2015, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 42, S298 - S298, English
    Summary international conference

  • Introducing the Glucose Metabolism to Amyloid Deposition Ratio Image
    K. Ishii, R. Takahashi, Y. Wakabyashi, C. Hosokawa, H. Kaida, T. Murakami
    Oct. 2015, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 42, S546 - S546, English
    Summary international conference

  • Therapy planning and dose prescription in radioiodine-131 therapy for hyperthyroidism using radioiodine-123 SPECT/CT imaging
    K. Hanaoka, M. Hosono, M. Otsuka, Y. Asai, M. Okumura, K. Ishii, T. Murakami
    Oct. 2015, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 42, S845 - S846, English
    Summary international conference

  • 細川 知紗, 石井 一成
    先端医療技術研究所, Sep. 2015, PET Journal, (31) (31), 10 - 11, Japanese

  • 超急性期脳梗塞症例に対する頭部単純CT画像を用いたコンピューター支援診断システムの開発
    渡邊 翔太, 坂口 健太, 細野 眞, 石井 一成, 村上 卓道
    (公社)日本放射線技術学会, Sep. 2015, 日本放射線技術学会雑誌, 71(9) (9), 896 - 896, Japanese

  • 放射性医薬品投与量の見直しと撮像技術 成人投与量の診断参考レベル
    石井 一成
    (一社)日本核医学会, Sep. 2015, 核医学, 52(3) (3), 095 - 095, Japanese

  • 膵癌のFDG集積とmTOR関連マーカーとの相関性に関する分子病理学的検討
    甲斐田 勇人, 東 公一, 河原 明彦, 安永 昌史, 服部 聡, 倉田 精二, 廣瀬 靖光, 鹿毛 政義, 石井 一成, 村上 卓道, 石橋 正敏
    (一社)日本核医学会, Sep. 2015, 核医学, 52(3) (3), 248 - 248, Japanese

  • PiB陰性例の18F-FDG PETによる脳代謝分布の検討
    細川 知紗, 石井 一成, 若林 雄一, 兵頭 朋子, 花田 一志, 甲斐田 勇人, 細野 眞, 木村 裕一, 村上 卓道
    (一社)日本核医学会, Sep. 2015, 核医学, 52(3) (3), 262 - 262, Japanese

  • アミロイドイメージングにおける組織放射能時間曲線に対するパターン認識による参照領域設定アルゴリズム
    木村 裕一, 山田 誉大, 細川 知紗, 石井 一成, 村上 卓道
    (一社)日本核医学会, Sep. 2015, 核医学, 52(3) (3), 293 - 293, Japanese

  • 石井 一成
    (NPO)日本核医学技術学会, Sep. 2015, 核医学技術, 35(予稿集) (予稿集), 293 - 293, Japanese

  • The correlation of dual phase F-18-FDG PET/CT to immunohistochemical prognostic factors in breast cancer patients
    Hayato Kaida, Uhi Toh, Akihiko Kawahara, Seiji Kurata, Yasumitsu Hirose, Masayoshi Kage, Kazunari Ishii, Takamichi Murakami, Masatoshi Ishibashi
    May 2015, JOURNAL OF NUCLEAR MEDICINE, 56(3) (3), English
    Summary international conference

  • Increased Pittsburgh Compound B accumulation in the regional white matters of Alzheimer brain
    Yuichi Wakabayashi, Kazunari Ishii, Chisa Hosokawa, Tomoko Hyodo, Takenori Kozuka, Takamichi Murakami, Kazuro Sugimura
    May 2015, JOURNAL OF NUCLEAR MEDICINE, 56(3) (3), English
    Summary international conference

  • 花田 一志, 西郷 和真, 上田 昌美, 石井 一成, 白川 治, 福田 寛二
    (株)ワールドプランニング, May 2015, 老年精神医学雑誌, 26(増刊II) (増刊II), 206 - 206, Japanese

  • 石井 一成
    (一社)大阪府内科医会, Apr. 2015, 大阪府内科医会会誌, 24(1) (1), 76 - 76, Japanese

  • 後縦隔に発生したectopic neural tissueの1例
    朝戸信行, 松木充, 福井秀行, 藤谷哲也, 任誠雲, 千葉輝明, 高橋洋人, 兵頭朋子, 山田稔, 柳生行伸, 鶴崎正勝, 岡田真広, 柏木伸夫, 細川知紗, 小塚健倫, 今岡いずみ, 足利竜一朗, 石井一成, 村上卓道
    (公社)日本医学放射線学会, Feb. 2015, Jpn J Radiol, 33(Suppl.) (Suppl.), 77 - 77, Japanese

  • Kengo Ito, SEAD-J Study Group, Hidenao Fukuyama, Michio Senda, Kazunari Ishii, Kiyoshi Maeda, Yasuji Yamamoto, Yasuomi Ouchi, Kenji Ishii, Ayumu Okumura, Ken Fujiwara, Takashi Kato, Yutaka Arahata, Yukihiko Washimi, Yoshio Mitsuyama, Kenichi Meguro, Mitsuru Ikeda
    IOS Press, 2015, Journal of Alzheimer's Disease, 45(2) (2), 543 - 552, English
    [Refereed]
    Report scientific journal

  • 若林 雄一, 石井 一成, 河内 崇, 細川 知紗, 山川 美帆, 兵頭 朋子, 任 誠雲, 鶴崎 正勝, 足利 竜一郎, 松木 充, 細野 眞, 北村 登, 村上 卓道
    (一社)日本核医学会, Nov. 2014, 核医学, 51(4) (4), 438 - 439, Japanese

  • K. Ishii
    American Society of Neuroradiology, 01 Nov. 2014, American Journal of Neuroradiology, 35(11) (11), 2030 - 2038, English
    Book review

  • Predictive value of heterogeneity of intratumoral In-111-Zevalin and FDG distributions for tumor response in Zevalin therapy
    M. Hosono, K. Hanaoka, K. Ishii, K. Sakaguchi, M. Yamada, Y. Komeya, N. Tsuchiya, S. Im, Y. Tatsumi, I. Matsumura
    Oct. 2014, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 41, S174 - S174, English
    Summary international conference

  • Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition
    K. Ishii, C. Hosokawa, T. Hyodo, Y. Wakabayashi, M. Yamada, T. Kozuka, M. Hosono, T. Murakami
    Oct. 2014, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 41, S619 - S619, English
    Summary international conference

  • 血中oxDJ-1の異常高値を示し、幻覚を認めたPDの4例
    西郷 和真, 斎藤 芳郎, 小川 郁子, 細井 幸恵, 三井 良之, 花田 一志, 上田 昌美, 石井 一成, 野口 範子, 楠 進
    (一社)日本認知症学会, Oct. 2014, Dementia Japan, 28(4) (4), 504 - 504, Japanese

  • 軽症アルツハイマー病の18F-FDG PETと11C-PiB PET検査の経時的画像変化の検討
    細川 知紗, 石井 一成, 兵頭 朋子, 坂口 健太, 宇佐美 公男, 若林 雄一, 鶴崎 正勝, 松木 充, 細野 眞, 村上 卓道
    (一社)日本核医学会, Sep. 2014, 核医学, 51(3) (3), 284 - 284, Japanese

  • 加齢の画像診断 最新情報 正常な加齢における脳血流量、代謝、およびアミロイドの蓄積(Imaging of Aging: up to date Cerebral blood flow, metabolism and amyloid deposition in normal aging)
    石井 一成
    (公社)日本医学放射線学会, Sep. 2014, 日本医学放射線学会秋季臨床大会抄録集, 50回, S593 - S593, English

  • 血中酸化型DJ‐1異常高値の臨床的意義
    西郷和真, 斎藤芳郎, 小川郁子, 細井幸恵, 三井良之, 花田一志, 上田昌美, 石井一成, 野口範子, 楠進
    29 Aug. 2014, 日本酸化ストレス学会学術集会プログラム・抄録集, 67th, 52, Japanese

  • Comparison between SUV and BP images acquired using 11C-PIB PET: Questionable PIB accumulation in SUV images
    Chisa Hosokawa, Kazunari Ishii, Yuichi Kimura, Kenta Sakaguchi, Makoto Hosono, Takamichi Murakami
    May 2014, JOURNAL OF NUCLEAR MEDICINE, 55, English
    Summary international conference

  • 多発結節影を呈した肺アミロイドーシスの1例
    日高 正二朗, 小塚 健倫, 柳生 行伸, 柏木 伸夫, 今岡 いずみ, 松木 充, 足利 竜一朗, 細野 眞, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2014, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 39 - 39, Japanese

  • 蠕動運動の月経周期による変化を観察した双角子宮の1例
    荒木 哲朗, 今岡 いずみ, 日高 正二朗, 岡田 真広, 柳生 行伸, 松木 充, 足利 竜一朗, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2014, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 40 - 40, Japanese

  • 腫瘤形成した慢性唾液腺炎のFDG-PET/CT所見
    細川 知紗, 柏木 伸夫, 松久保 祐子, 山田 穣, 任 誠雲, 兵頭 朋子, 高橋 洋人, 柳生 行伸, 岡田 真広, 小塚 健倫, 今岡 いずみ, 鶴崎 正勝, 松木 充, 足利 竜一郎, 細野 眞, 石井 一成, 村上 卓道, 筑後 雅章
    (公社)日本医学放射線学会, Feb. 2014, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 45 - 45, Japanese

  • 認知症性疾患の多様性 正常圧水頭症
    石井 一成
    日本メジフィジックス(株), Dec. 2013, ブレイン・ファンクション・イメージング・カンファレンス記録集, (29) (29), 16 - 16, Japanese

  • 細川 知紗, 石井 一成, 木村 裕一, 兵頭 朋子, 坂口 健太, 宇佐美 公男, 細野 眞, 村上 卓道
    (一社)日本核医学会, Nov. 2013, 核医学, 50(4) (4), 327 - 327, Japanese

  • Detection and Differential Diagnosis of Hepatic Metastasis on Gd-EOB-DTPA-Enhanced MR Imaging
    TSURUSAKI M, HYODO T, IM S, OKADA M, MATSUKI M, ASHIKAGA R, ISHII K, MURAKAMI T
    バイエル薬品(株), Nov. 2013, NICHIDOKU-IHO, 58(2) (2), 203 - 211, Japanese

  • Computer assisted diagnosis system for dementia with 3D-SSP : ZSAM software
    石井 一成
    金原出版(株), Oct. 2013, 臨床放射線, 58(10) (10), 1311 - 1318, Japanese

  • Therapy planning and dose prescription in radioiodine therapy for hyperthyroidism using SPECT/CT
    M. Hosono, K. Hanaoka, K. Ishii, S. Im, K. Sakaguchi, Y. Yagyu, Y. Matsukubo, Y. Ohno, H. Ikegami
    Oct. 2013, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 40, S231 - S232, English
    Summary international conference

  • PiB陽性MCIにおけるAPOE4のPiB取り込み、局所脳萎縮への効果
    高橋 竜一, 石井 一成, 松田 博史, 千田 道雄, 石井 賢二, 加藤 隆司, 伊藤 健吾, 杉下 守弘, 朝田 隆, 桑野 良三
    (一社)日本認知症学会, Oct. 2013, Dementia Japan, 27(4) (4), 504 - 504, Japanese

  • ここが知りたい認知症の画像診断 脳血流SPECT/FDG-PET 基本的な読影のポイント
    石井 一成
    (公社)日本医学放射線学会, Sep. 2013, 日本医学放射線学会秋季臨床大会抄録集, 49回, S479 - S479, Japanese

  • 石井 一成
    (一社)日本核医学会, Sep. 2013, 核医学, 50(3) (3), S136 - S136, Japanese

  • 細川 知紗, 石井 一成, 木村 裕一, 兵頭 朋子, 細野 眞, 坂口 健太, 宇佐美 公男, 村上 卓道
    (一社)日本核医学会, Sep. 2013, 核医学, 50(3) (3), S182 - S182, Japanese

  • 石井 一成
    (株)学研メディカル秀潤社, Aug. 2013, 画像診断, 33(10) (10), 1183 - 1192, Japanese

  • 石井 一成
    先端医療技術研究所, Jun. 2013, PET Journal, (22) (22), 35 - 36, Japanese

  • 大腿四頭筋血腫の経過で隣接骨の皮質過形成をきたした1例
    森田 敬裕, 柏木 伸夫, 兵頭 朋子, 柳生 行伸, 小塚 健倫, 熊野 正士, 今岡 いずみ, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2013, Japanese Journal of Radiology, 31(Suppl.I) (Suppl.I), 47 - 47, Japanese

  • 外傷性神経腫の1例
    藤谷 哲也, 柏木 伸夫, 今岡 いずみ, 熊野 正士, 石井 一成, 足利 竜一朗, 村上 卓道, 前西 修, 楠原 廣久, 磯貝 典孝
    (公社)日本医学放射線学会, Feb. 2013, Japanese Journal of Radiology, 31(Suppl.I) (Suppl.I), 53 - 53, Japanese

  • Dual-energy CTによる肝脂肪定量 ファントム実験によるsingle-energy CTおよびMRSとの比較
    兵頭 朋子, 岡田 真広, 工藤 正幸, 鶴崎 正勝, 足利 竜一朗, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2013, 日本医学放射線学会学術集会抄録集, 72回, S251 - S251, Japanese

  • 3D Arterial spin labelingによるアルツハイマー病の脳灌流画像 SPECTとの比較(Brain perfusion imaging of Alzheimer's disease with 3D arterial spin labeling: Comparison with brain perfusion SPECT)
    高橋 洋人, 石井 一成, 柏木 伸夫, 宮越 敬三, 花岡 宏平, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2013, 日本医学放射線学会学術集会抄録集, 72回, S282 - S282, English

  • 言語課題における「難易度」と脳賦活領域:fMRIによる検討
    岡田理恵子, 中野直樹, 宮内正晴, 石井一成, 村上卓道, 大槻俊輔, 加藤天美
    2013, 日本ヒト脳機能マッピング学会プログラム・抄録集, 15th, 84, Japanese

  • 「3D-SSP解析による診断補助解析法」 Z-SAMによる検討
    石井 一成, 外山 宏
    日本メジフィジックス(株), Dec. 2012, ブレイン・ファンクション・イメージング・カンファレンス記録集, (28) (28), 8 - 8, Japanese

  • 111In‐ゼバリンSPECT/CTで腫瘍活性残存を検出できた非ホジキンリンパ腫の一例
    米矢吉宏, 細野眞, 山田穣, 松木充, 花岡宏平, 坂口健太, 任誠雲, 柳生行伸, 石井一成, 辰巳陽一, 松村到, 土屋典生
    (一社)日本核医学会, 30 Nov. 2012, 核医学, 49(4) (4), 439 - 439, Japanese

  • 【年齢別特徴をふまえた脳神経画像診断-小児から成人まで-】感染症
    松木 充, 藤谷 哲也, 松久保 祐子, 高橋 洋人, 柏木 伸夫, 足利 竜一郎, 石井 一成, 村上 卓道
    (株)学研メディカル秀潤社, Oct. 2012, 画像診断, 32(13) (13), 1252 - 1267, Japanese

  • Combination of FDG-PET and hippocampal volumetry for prediction of conversion to Alzheimer disease in subjects with mild cognitive impairments: Study on diagnosis of early Alzheimer disease-Japan (SEAD-J)
    K. Ishii, K. Ishii, T. Kato, M. Senda, K. Ito
    Oct. 2012, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 39, S434 - S435, English
    Summary international conference

  • Three dimensional planning of radioiodine therapy for hyperthyroidism by iodine-123 SPECT/CT
    K. Hanaoka, M. Hosono, T. Kurokawa, K. Sakaguchi, S. Yoshida, R. Inoue, K. Ishii, T. Murakami
    Oct. 2012, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 39, S309 - S309, English
    Summary international conference

  • Prediction of tumor response by Indium-111-Zevalin SPECT/CT and FDG-PET/CT in radioimmunotherapy for B-cell non-Hodgkin lymphoma
    M. Hosono, K. Hanaoka, K. Ishii, K. Sakaguchi, S. Im, N. Tsuchiya, Y. Komeya, Y. Yagyu, Y. Tatsumi, I. Matsumura
    Oct. 2012, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 39, S372 - S372, English
    Summary international conference

  • J-ADNI被験者の登録時区分によるFDG-PETの比較
    藤原 謙, 加藤 隆司, 石井 賢二, 石井 一成, 千田 道雄, 伊藤 健吾
    (一社)日本認知症学会, Oct. 2012, Dementia Japan, 26(4) (4), 483 - 483, Japanese

  • 認知症の多施設共同研究をサポートする「ネット画像カンファレンスシステム」の開発
    中村 昭範, 加藤 隆司, 井狩 彌彦, 千田 道雄, 石井 一成, 石井 賢二, 西尾 知之, 宮 ゆかり, 伊藤 健吾, J-ADNI study group
    (一社)日本認知症学会, Oct. 2012, Dementia Japan, 26(4) (4), 484 - 484, Japanese

  • 兵頭 朋子, 岡田 真広, 矢田 典久, 前西 修, 香川 祐毅, 任 誠雲, 柏木 伸夫, 柳生 行伸, 今岡 いずみ, 松木 充, 足利 竜一朗, 石井 一成, 工藤 正俊, 村上 卓道
    近畿大学医学会, Sep. 2012, 近畿大学医学雑誌, 37(3-4) (3-4), 18A - 18A, Japanese

  • 【よくわかる脳MRI(第3版)】変性疾患とその類縁疾患【認知症を来す疾患】Lewy小体型認知症、認知症を伴うパーキンソン病
    石井 一成
    (株)学研メディカル秀潤社, Sep. 2012, 画像診断, 別冊(よくわかる脳MRI第3版) (よくわかる脳MRI第3版), 592 - 593, Japanese

  • 【よくわかる脳MRI(第3版)】変性疾患とその類縁疾患【認知症を来す疾患】特発性正常圧水頭症
    石井 一成
    (株)学研メディカル秀潤社, Sep. 2012, 画像診断, 別冊(よくわかる脳MRI第3版) (よくわかる脳MRI第3版), 608 - 609, Japanese

  • 特発性正常圧水頭症の画像診断
    石井 一成
    (公社)日本医学放射線学会, Aug. 2012, 日本医学放射線学会秋季臨床大会抄録集, 48回, S458 - S458, Japanese

  • Diagnostic imaging for idiopathic normal pressure hydrocephalus
    石井 一成
    (株)ワールドプランニング, Jul. 2012, 老年精神医学雑誌, 23(7) (7), 815 - 820, Japanese

  • 嶋田 兼一, 小田 陽彦, 長谷川 雅史, 寺島 明, 石井 一成
    (株)ワールドプランニング, Jun. 2012, 老年精神医学雑誌, 23(増刊II) (増刊II), 208 - 208, Japanese

  • 脳血管障害・認知症 (特集 糖尿病の画像診断 : CT/MR,核医学をどのように利用するか)
    高橋 竜一, 石井 一成
    医学出版, Jun. 2012, 糖尿病, 4(6) (6), 27 - 33, Japanese

  • 【脳室と髄液腔の最新情報】特発性正常圧水頭症(iNPH) iNPHの画像診断
    石井 一成
    (株)中外医学社, Apr. 2012, Clinical Neuroscience, 30(4) (4), 420 - 424, Japanese

  • Diagnostic imaging in guidelines for management of idiopathic normal pressure hydrocephalus
    石井 一成, 塚部 明大, 森 悦朗, 新井 一, 石川 正恒
    金原出版(株), Mar. 2012, 臨床放射線, 57(3) (3), 343 - 348, Japanese

  • Guidelines for Nuclear Medicine in Diabetes Mellitus and it's Complications
    西村 恒彦, 石井 一成, 奥山 智緒, 塩見 進, 玉木 長良, 中嶋 憲一, 中田 智明, 長谷 弘記, 畑澤 順, 藤林 靖久, 山崎 純一, 川村 悦史, 清野 泰, 小谷 晃平, 常喜 信彦, 高橋 竜一, 橋本 暁佳, 松尾 信郎, 松島 成典, 山科 昌平, 吉永 恵一郎, 渡部 直史, 柏木 厚典, 河盛 隆造, 島本 和明, 中村 直登, 山崎 義光
    29 Feb. 2012, 核医学 : 日本核医学会機関誌 : the Japanese journal of nuclear medicine, 49(1) (1), 16 - 20, Japanese

  • 慢性GVHDに伴う舌papillomatosisから発生した舌癌の1例
    加藤 里枝子, 勝部 敬, 下野 太郎, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2012, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 41 - 41, Japanese

  • Gd-EOB-DTPA造影MRIでの肝機能評価の試み T1 Mapping法を用いて
    勝部 敬, 岡田 真広, 熊野 正士, 藤谷 哲也, 森田 敬裕, 今岡 いずみ, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2012, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 43 - 43, Japanese

  • 高速多相撮像を用いた多血性肝細胞癌の最適撮像時間の検討
    香川 祐毅, 岡田 真広, 柳生 行伸, 小塚 健倫, 熊野 正士, 今岡 いずみ, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2012, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 47 - 47, Japanese

  • 知っておきたい認知症の画像診断 脳血流検査の要点
    石井 一成
    (公社)日本医学放射線学会, Feb. 2012, 日本医学放射線学会学術集会抄録集, 71回, S92 - S92, Japanese

  • Dual energy CTを用いた肝脂肪の定量評価 ファントム実験と初期臨床経験
    兵頭 朋子, 岡田 真広, 矢田 典久, 工藤 正幸, 香川 祐毅, 熊野 正士, 石井 一成, 工藤 正俊, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2012, 日本医学放射線学会学術集会抄録集, 71回, S272 - S272, Japanese

  • ASIRを用いた低電圧肝Dynamic-CTによる被曝低減と造影剤量低減に関する報告
    日高 正二朗, 高橋 洋人, 岡田 真広, 兵頭 朋子, 香川 祐毅, 今岡 いずみ, 石井 一成, 足利 竜一朗, 工藤 正俊, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2012, 日本医学放射線学会学術集会抄録集, 71回, S273 - S273, Japanese

  • iNPH患者の脳血流SPECTによる評価:Convexity APPArent Hyperperfusion(CAPPAH:河童サイン)
    徳田隆彦, 徳田隆彦, 小泉英貴, 近藤正樹, 栗山長門, 奥山智緒, 石井一成, 森悦朗, 中川正法
    2012, 日本正常圧水頭症学会プログラム・抄録集, 13th (Web)

  • 認知症における脳血流SPECT読影ポイント
    石井 一成
    日本メジフィジックス(株), Dec. 2011, ブレイン・ファンクション・イメージング・カンファレンス記録集, (27) (27), 15 - 15, Japanese

  • 兵頭 朋子, 岡田 真広, 香川 祐毅, 熊野 正士, 任 誠雲, 柏木 伸夫, 柳生 行伸, 今岡 いずみ, 足利 竜一朗, 石井 一成, 工藤 正俊, 村上 卓道
    近畿大学医学会, Dec. 2011, 近畿大学医学雑誌, 36(3-4) (3-4), 13A - 13A, Japanese

  • 山根 登茂彦, 西尾 知之, 井狩 彌彦, 真喜志 瑶子, 石井 一成, 石井 賢二, 加藤 隆司, 伊藤 健吾, 千田 道雄
    (一社)日本核医学会, Nov. 2011, 核医学, 48(4) (4), 466 - 466, Japanese

  • Indium-111-Zevalin-SPECT/CT and FDG-PET/CT as quantitative evaluation in radioimmunotherapy for B-cell non-Hodgkin's lymphoma
    K. Hanaoka, M. Hosono, Y. Yamazoe, Y. Tatsumi, Y. Komeya, N. Tsuchiya, K. Ishii, K. Usami, T. Murakami, T. Uto
    Oct. 2011, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 38, S426 - S426, English
    Summary international conference

  • FDG-PET and automatic diagnosis systems for prediction of conversion to Alzheimer disease in subjects with mild cognitive impairments: Study on diagnosis of early Alzheimer disease-Japan (SEAD-J)
    K. Ishii, K. Ito, M. Senda, K. Ishii, T. Kato, H. Fukuyama, Y. Ouchi, K. Meguro, A. Okumura, Y. Mitsuyama, G. Sead-J
    Oct. 2011, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 38, S108 - S109, English
    Summary international conference

  • PiB陽性、陰性aMCIにおける局所糖代謝の検討
    高橋 竜一, 石井 一成, 石井 賢二, 加藤 隆司, 千田 道雄, 伊藤 健吾, 杉下 守弘, 岩坪 威
    (一社)日本認知症学会, Oct. 2011, Dementia Japan, 25(3) (3), 328 - 328, Japanese

  • PiB陽性aMCIにおけるApoE ε 4のPiB集積や局所糖代謝への効果
    高橋 竜一, 石井 一成, 石井 賢二, 加藤 隆司, 千田 道雄, 伊藤 健吾, 杉下 守弘, 桑野 良三, 岩坪 威
    (一社)日本認知症学会, Oct. 2011, Dementia Japan, 25(3) (3), 329 - 329, Japanese

  • 米矢 吉宏, 細野 眞, 土屋 典生, 熊野 正士, 山田 譲, 任 誠雲, 柳生 行伸, 石井 一成, 足利 竜一朗, 西村 恭昌, 村上 卓道
    (一社)日本核医学会, Sep. 2011, 核医学, 48(3) (3), S272 - S272, Japanese

  • 石井 一成, 橋本 正明, 林田 孝平, 橋川 一雄, 張 家正, 中川原 譲二, 中山 禎司, 森 敏, 榊原 隆次
    (一社)日本核医学会, Sep. 2011, 核医学, 48(3) (3), S286 - S286, Japanese

  • 高橋 竜一, 石井 一成, 柿木 達也, 横山 和正
    神緑会, Aug. 2011, 神戸大学医学部神緑会学術誌, 27(27) (27), 65 - 67, Japanese

  • 石井 一成
    近畿大学医学会, Mar. 2011, 近畿大学医学雑誌, 36(1) (1), 21A - 21A, English

  • 高速多相性CT撮像を用いた多血性肝細胞癌の最適な撮像時間の検討
    香川 祐毅, 岡田 真広, 柳生 行伸, 熊野 正士, 石井 一成, 村上 卓道
    近畿大学医学会, Mar. 2011, 近畿大学医学雑誌, 36(1) (1), 19 - 24, Japanese

  • 特発性正常圧水頭症診療ガイドライン改訂(案)における画像診断
    石井 一成, 塚部 明大, 森 悦朗, 新井 一, 石川 正恒, 日本正常圧水頭症INPH診療ガイドライン改訂委員会
    (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S133 - S134, Japanese

  • Gd-EOB-DTPA造影MRIにおけるHCCのT1値の経時的変化について T1 mappingを用いた定量的な検討
    森田 敬裕, 熊野 正士, 岡田 真広, 兵頭 朋子, 柏木 伸夫, 柳生 行伸, 今岡 いずみ, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S275 - S276, Japanese

  • SSFSE像におけるHCCに対するEOB造影の経時的影響 1.5Tと3.0Tの比較
    荒木 哲朗, 岡田 真広, 熊野 正士, 柳生 行伸, 柏木 伸夫, 小塚 健倫, 今岡 いずみ, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S276 - S276, Japanese

  • Gd-EOB-DTPA造影MRI肝細胞相で検出された慢性障害肝の乏血性結節 多血化の危険因子
    兵頭 朋子, 岡田 真広, 香川 祐毅, 熊野 正士, 堀 雅敏, 石井 一成, 今井 康陽, 望月 輝一, 工藤 正俊, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S342 - S343, Japanese

  • 収集時間の減少が123I-IMP脳血流SPECT/CT検査に与える影響について
    花岡 宏平, 坂口 健太, 大塚 正和, 澄田 貢, 石井 一成, 村上 卓道, 細野 眞
    (公社)日本放射線技術学会, Feb. 2011, 日本放射線技術学会総会学術大会予稿集, 67回, 251 - 251, Japanese

  • 減弱を考慮した副腎皮質アドステロール摂取率の簡易的な算出方法
    大塚 正和, 花岡 宏平, 宇佐美 公男, 澄田 貢, 石井 一成, 村上 卓道, 細野 眞
    (公社)日本放射線技術学会, Feb. 2011, 日本放射線技術学会総会学術大会予稿集, 67回, 320 - 320, Japanese

  • 村上 卓道, 岡田 真広, 今岡 いずみ, 石井 一成, 工藤 正幸
    産業開発機構(株), Jan. 2011, 映像情報Medical, 43(1) (1), 28 - 31, Japanese

  • 照射野外固定の卵巣病変およびその機能性変化
    香川 祐毅, 今岡 いずみ, 加藤 里枝子, 安藤 里奈, 桑原 雅知, 岡田 真広, 熊野 正士, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, Jan. 2011, Japanese Journal of Radiology, 29(Suppl.I) (Suppl.I), 57 - 57, Japanese

  • 左視床前部梗塞における認知障害と視床-皮質回路離断
    西尾 慶之, 橋本 衛, 石井 一成, 伊藤 大輔, 麦倉 俊司, 高橋 昭喜, 森 悦朗
    (一社)日本神経学会, Dec. 2010, 臨床神経学, 50(12) (12), 1150 - 1150, Japanese

  • 【認知症の画像診断 Alzheimer病から稀な疾患まで】機能画像診断 核医学
    石井 一成
    (株)学研メディカル秀潤社, Nov. 2010, 画像診断, 30(14) (14), 1466 - 1476, Japanese

  • 【知っておきたい認知症の臨床と画像】疾患各論 正常圧水頭症
    石井 一成, 柿木 崇秀
    金原出版(株), Oct. 2010, 臨床放射線, 55(11) (11), 1507 - 1514, Japanese

  • FDG uptake in bone marrow after G-CSF administration in patients with non-Hodgkin lymphoma
    K. Hanaoka, M. Hosono, Y. Komeya, N. Tsuchiya, K. Usami, Y. Yamazoe, K. Ishii, Y. Tatsumi, T. Murakami
    Oct. 2010, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 37, S433 - S433, English
    Summary international conference

  • Computer-assisted system for diagnosis of Alzheimer's disease using database-independent estimation using FDG PET and 3D-SSP
    K. Ishii, T. Uemura, N. Miyamoto, T. Yoshikawa
    Oct. 2010, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 37, S397 - S397, English
    Summary international conference

  • 熊野 正士, 岡田 真広, 柳生 行伸, 今岡 いずみ, 石井 一成, 足利 竜一朗, 細野 眞, 村上 卓道
    (株)医学書院, Sep. 2010, 肝胆膵画像, 12(5) (5), 585 - 591, Japanese

  • RI標識モノクローナル抗体療法におけるIn-Zevalin、FDGの腫瘍集積と奏効の関係について
    花岡 宏平, 細野 眞, 米矢 吉宏, 土屋 典生, 山添 譲, 宇佐美 公男, 澄田 貢, 石井 一成, 村上 卓道
    (一社)日本核医学会, Sep. 2010, 核医学, 47(3) (3), 432 - 432, Japanese

  • 各種ガイドラインに基づく脳神経核医学検査の有効活用 エビデンスに基づく脳神経核医学検査ガイドライン(認知症)
    石井 一成
    日本メジフィジックス(株), Sep. 2010, ブレイン・ファンクション・イメージング・カンファレンス記録集, (26) (26), 27 - 30, Japanese

  • MCIからADへの移行予測指標の探索 FDG-PETを中心とした検討
    山田 貴史, 伊藤 健吾, 加藤 隆司, 目黒 謙一, 石井 賢二, 尾内 康臣, 鷲見 幸彦, 新畑 豊, 福山 秀直, 石井 一成, 千田 道雄
    (一社)日本認知症学会, Sep. 2010, Dementia Japan, 24(3) (3), 305 - 305, Japanese

  • 健常者における脳糖代謝画像の変動要因ならびに認知機能との関係
    加藤 隆司, 伊藤 健吾, 千田 道雄, 石井 賢二, 石井 一成, 藤原 謙, 井狩 彌彦, 西尾 知之, 真喜志 瑶子
    (一社)日本核医学会, Sep. 2010, 核医学, 47(3) (3), 398 - 398, Japanese

  • FDG-PET画像解析(AD-tsum法)を中心としたMCIからADへの移行予測の検討
    山田 貴史, 伊藤 健吾, 加藤 隆司, 福山 秀直, 千田 道雄, 尾内 康臣, 石井 一成, 石井 賢二, 目黒 謙一
    (一社)日本核医学会, Sep. 2010, 核医学, 47(3) (3), 412 - 412, Japanese

  • Possibilities of the Evaluation in Liver Function with Gd-EOBDTPA Enhanced MRI
    Okada M, Katsube T, Kagawa Y, Hyodo T, Kumano S, Imaoka I, Ishii K, Imai Y, Kudo M, Murakami T
    バイエル薬品(株), Sep. 2010, NICHIDOKU-IHOU, 55(2) (2), 179 - 186, Japanese

  • 急性期心筋梗塞患者における3T心臓MRI-T2強調画像の落とし穴
    河野 淳, 藤井 正彦, 杉村 和朗, 神田 知紀, 宮本 直和, 吉川 俊紀, 石井 一成, 谷口 泰代, 梶谷 定志
    (公社)日本医学放射線学会, Jul. 2010, Japanese Journal of Radiology, 28(Suppl.I) (Suppl.I), 46 - 46, Japanese

  • MRIおよびCTを用いた画像的肝機能評価
    岡田 真広, 熊野 正士, 勝部 敬, 香川 祐毅, 栗生 明博, 今岡 いずみ, 石井 一成, 今井 康陽, 工藤 正俊, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 69回, S134 - S134, Japanese

  • SPECT/CTによる脳血流SPECTの減弱補正効果
    栗生 明博, 石井 一成, 米谷 吉宏, 柳生 行伸, 熊野 正士, 足利 竜一朗, 細野 眞, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 69回, S183 - S184, Japanese

  • 油性造影剤マイオジールの頭蓋内MRI所見についての検討
    下野 太郎, 足利 竜一朗, 柳生 行伸, 桑原 雅知, 勝部 敬, 栗生 明博, 石井 一成, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 69回, S206 - S206, Japanese

  • 3T MRI高分解能画像による正常子宮の蠕動評価
    安藤 理奈, 今岡 いずみ, 香川 祐毅, 加藤 里枝子, 柳生 行伸, 岡田 真広, 熊野 正士, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 69回, S274 - S275, Japanese

  • Gd-EOB-DTPA造影MRIと肝機能評価 T1 Mapping法を用いて
    勝部 敬, 岡田 真広, 熊野 正士, 香川 祐毅, 栗生 明博, 奥秋 知幸, 今岡 いずみ, 石井 一成, 足利 竜一朗, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 69回, S293 - S293, Japanese

  • 三次元差分処理を用いた副甲状腺SPECT/CT画像について
    花岡 宏平, 坂口 健太, 宇佐美 公男, 森元 英夫, 澄田 貢, 石井 一成, 細野 眞
    (公社)日本放射線技術学会, Feb. 2010, 日本放射線技術学会総会学術大会予稿集, 66回, 226 - 227, Japanese

  • 呼吸同期装置を用いない呼吸同期SPECT収集の検討
    坂口 健太, 花岡 宏平, 森元 英夫, 宇佐美 公男, 澄田 貢, 石井 一成, 細野 眞
    (公社)日本放射線技術学会, Feb. 2010, 日本放射線技術学会総会学術大会予稿集, 66回, 280 - 280, Japanese

  • Disruption of Thalamocortical Interconnections in Neurobehavioral Disturbance after Left Anterior Thalamic Infarction
    Yoshiyuki Nishio, Mamoru Hashimoto, Kazunari Ishii, Daisuke Ito, Shunji Mugikura, Shoki Takahashi, Etsuro Mori
    2010, ANNALS OF NEUROLOGY, 68(4) (4), S67 - S68, English
    Summary international conference

  • ISHII Kazunari
    The Japanese Society of Medical Imaging Technology, Jan. 2010, Medical Imaging Technology, 28(1) (1), 14 - 18, Japanese

  • 脳PETの現状と将来展望
    石井 一成
    臨床における脳PETの現状と将来展望について概説した。脳におけるFEG-PET(脳腫瘍、てんかん、認知症)、画像統計解析法、脳PETの使用状況について述べ、アルツハイマー病(AD)の早期診断における多施設共同研究を紹介し、ADの原因とされている脳内に沈着するアミロイドβ蛋白を画像化するアミロイドイメージングについても言及した。
    先端医療技術研究所, Dec. 2009, PET Journal, (8) (8), 7 - 9, Japanese

  • エビデンスに基づく脳神経核医学検査ガイドライン : 2009年
    橋川 一雄, 岡沢 秀彦, 小笠原 邦昭, 奥 直彦, 下瀬川 恵久, 中川原 譲二, 林田 孝平, 石井 一成, 伊藤 健吾, 桑原 康雄, 松田 博史, 東海林 幹夫, 大槻 泰介
    30 Nov. 2009, 核医学 : 日本核医学会機関誌 : the Japanese journal of nuclear medicine, 46(4) (4), 1 - 37, Japanese

  • MCIを対象としたアルツハイマー型痴呆の早期診断に関する研究(J-COSMIC) 画像解析(2)
    石井 一成, 伊藤 健吾, 松田 博史, 桑原 康雄, 橋川 一雄, 百瀬 敏光, 内田 佳孝, 畑澤 順, 蓑島 聡, 米倉 義晴
    (一社)日本核医学会, Sep. 2009, 核医学, 46(3) (3), 266 - 266, Japanese

  • 認知症の診断と治療の最新情報 追加発言 アルツハイマー病における脳核医学検査ガイドライン
    石井 一成
    日本メジフィジックス(株), Sep. 2009, ブレイン・ファンクション・イメージング・カンファレンス記録集, (25) (25), 69 - 70, Japanese

  • アルツハイマー病早期診断に関する研究(SEAD-J)とUS-ADNIにおけるMCI患者の特徴とFDG-PET画像の比較
    川嶋 将司, 加藤 隆司, 伊藤 健吾, 千田 道雄, 石井 一成, 石井 賢二, 福山 秀直, 尾内 康臣, 目黒 謙一
    (一社)日本核医学会, Sep. 2009, 核医学, 46(3) (3), 266 - 266, Japanese

  • 石井 一成
    遺伝子および形態画像からアルツハイマー病(AD)の病態探索を実施した。初老期(65歳以下)および老年期(65歳以上)発症のADにおいてApoE遺伝子多型(e3/3、e4/4)が灰白質の萎縮部位および程度にどのような影響を与えるか検討した。初老期発症ApoE e3/3 ADでは楔前部、側頭頭頂葉皮質、側頭葉皮質、内側側頭葉、前部帯状回、老年期発症ApoE e3/3 ADでは内側側頭葉、前脳基底部、前部帯状回、側頭葉皮質で有意な灰白質密度の低下、すなわち萎縮がみられた。初老期発症ApoE e4/4 ADでは内側側頭葉、前部帯状回、楔前部、老年期発症ApoE e4/4 ADでは内側側頭葉のみに有意な灰白質密度の低下、すなわち萎縮がみられた。ADには発症年齢によるサブタイプがあり、ApoE遺伝子多型は内側側頭葉の萎縮を主体としたタイプの発症に関係するものと考えられた。
    (一社)神緑会, Aug. 2009, 神緑会学術誌, 25, 61 - 63, Japanese

  • 【老年精神医学の臨床最前線】認知症の診断-Update 認知症の早期・鑑別診断における機能画像の役割
    石井 一成
    (株)ワールドプランニング, Aug. 2009, 老年精神医学雑誌, 20(増刊III) (増刊III), 42 - 49, Japanese

  • 石井 一成
    神緑会, Aug. 2009, 神戸大学医学部神緑会学術誌, 25(25) (25), 61 - 63, Japanese

  • 石井 一成
    (株)メディカルレビュー社, Apr. 2009, Cognition and Dementia, 8(2) (2), 75 - 81, Japanese

  • 石井 一成
    (一社)日本核医学会, Mar. 2009, 核医学, 46(1) (1), 46 - 47, Japanese

  • 認知症の画像診断A to Z SPECT,PETを用いた認知症の診断
    石井 一成
    (公社)日本医学放射線学会, Feb. 2009, 日本医学放射線学会学術集会抄録集, 68回, S69 - S69, Japanese

  • 核医学 脳核医学の基礎と臨床 臨床編
    石井 一成
    (公社)日本医学放射線学会, Feb. 2009, 日本医学放射線学会学術集会抄録集, 68回, S93 - S93, Japanese

  • 腸骨動脈領域の末梢動脈疾患に対する血管内治療の有用性についての検討
    宮本 直和, 福田 哲也, 上村 尚文, 後藤 一, 吉川 俊紀, 石井 一成, 杉村 和朗
    (公社)日本医学放射線学会, Feb. 2009, 日本医学放射線学会学術集会抄録集, 68回, S216 - S216, Japanese

  • 胸部大動脈疾患に対するMKステントグラフト内挿術の有用性に関する検討
    上村 尚文, 宮本 直和, 福田 哲也, 吉田 正人, 向原 伸彦, 吉川 俊紀, 後藤 一, 石井 一成
    (公社)日本医学放射線学会, Feb. 2009, 日本医学放射線学会学術集会抄録集, 68回, S350 - S350, Japanese

  • 石井 一成, 相馬 努
    (株)インナービジョン, Jan. 2009, INNERVISION, 24(2) (2), 101 - 105, Japanese

  • 溝部 敬, 中村 貢, 本岡 康彦, 田中 一寛, 宮本 直和, 石井 一成
    (NPO)日本脳神経血管内治療学会, Nov. 2008, JNET: Journal of Neuroendovascular Therapy, 2(4) (4), 268 - 268, Japanese

  • 【核医学の最前線】進化するソフトウェア 3D-SSPによる脳機能解析
    石井 一成
    (株)メディカルアイ, Oct. 2008, Rad Fan, 6(12) (12), 36 - 39, Japanese

  • Multicenter cerebral perfusion SPECT study in idiopathic normal pressure hydrocephalus
    K. Ishii, M. Hashimoto, K. Hayashida, K. Hashikawa, C. C. Chang, T. Nakayama, J. Nakagawara, S. Mori, R. Sakakibara
    Oct. 2008, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 35, S313 - S313, English
    Summary international conference

  • 脳神経核医学 認知症の画像診断 認知症の核医学診断
    石井 一成
    (公社)日本医学放射線学会, Sep. 2008, 日本医学放射線学会秋季臨床大会抄録集, 44回, S483 - S484, Japanese

  • MCIを対象とするアルツハイマー病の早期診断に関する多施設共同研究(SEAD-J) 登録データの初期解析結果
    伊藤 健吾, 千田 道雄, 石井 一成, 石井 賢二, 加藤 隆司, 福山 秀直, 尾内 康臣, 目黒 謙一
    (一社)日本核医学会, Sep. 2008, 核医学, 45(3) (3), S180 - S180, Japanese

  • 清水 敬二, 千田 道雄, 石井 一成, 石井 賢二, 加藤 隆司, 松本 圭一, 伊藤 健吾
    (一社)日本核医学会, Sep. 2008, 核医学, 45(3) (3), S195 - S195, Japanese

  • 阪井 一雄, 大川 慎吾, 嶋田 兼一, 石井 一成, 大山 明美, 前田 潔
    (株)ワールドプランニング, Jun. 2008, 老年精神医学雑誌, 19(増刊II) (増刊II), 123 - 123, Japanese

  • PTAを施行した腹腔動脈起始部圧迫症候群の1例
    原田 文, 宮本 直和, 神田 知紀, 吉川 俊紀, 石井 一成, 五味 隆
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2008, IVR: Interventional Radiology, 23(2) (2), 220 - 220, Japanese

  • 外傷性内胸動脈損傷の一例
    北村 アキ, 宮本 直和, 溝口 和博, 本多 祐, 尾崎 喜就, 中桐 啓太郎, 吉田 正人, 向原 伸彦, 石井 一成, 志田 力
    (NPO)日本血管外科学会, Mar. 2008, 日本血管外科学会雑誌, 17(2) (2), 424 - 424, Japanese

  • 特発性正常圧水頭症の排尿障害と右前頭葉血流低下:[123I]‐IMP SPECTによる検討
    榊原隆次, 内田佳孝, 石井一成, 白井厚治, 内山智之, 山西友典
    (一社)日本内科学会, Feb. 2008, 日本内科学会雑誌, 97(Suppl.) (Suppl.), 251 - 251, Japanese

  • 3.0T装置におけるNASA法を用いた下肢非造影MRAの閉塞性動脈硬化症に対する有用性についての検討
    神田 知紀, 宮本 直和, 石本 剛, 上村 尚文, 吉川 俊紀, 石井 一成, 杉村 和朗
    (公社)日本医学放射線学会, Feb. 2008, 日本医学放射線学会学術集会抄録集, 67回, S169 - S169, Japanese

  • ApoE遺伝子多型による初老期および老年期発症アルツハイマー病の灰白質萎縮部位の差
    石井 一成, 高橋 竜一, 神田 知紀, 上村 尚文, 宮本 直和, 吉川 俊紀, 保田 稔, 森 悦朗
    (公社)日本医学放射線学会, Feb. 2008, 日本医学放射線学会学術集会抄録集, 67回, S245 - S245, Japanese

  • レビー小体型認知症の診断における神経心理検査の有用性の検討
    嶋田 兼一, 石井 一成, 山根 有美子, 福田 義文, 大川 愼吾
    (一社)日本神経学会, Dec. 2007, 臨床神経学, 47(12) (12), 1145 - 1145, Japanese

  • 腸骨動脈慢性完全閉塞病変PTA後の遠位塞栓による急性動脈閉塞に対して経皮的血栓除去術を行った2例
    宮本 直和, 福田 哲也, 上村 尚文, 神田 知紀, 吉川 俊紀, 石井 一成, 向原 伸彦
    (一社)日本インターベンショナルラジオロジー学会, Oct. 2007, IVR: Interventional Radiology, 22(4) (4), 499 - 499, Japanese

  • 前頭側頭型認知症における局所脳糖代謝・灰白質密度の検討
    神田 知紀, 石井 一成, 宮本 直和, 上村 尚文
    (一社)日本核医学会, Oct. 2007, 核医学, 44(3) (3), 302 - 302, Japanese

  • 特発性正常圧水頭症の排尿障害と右前頭葉血流低下:[123I]‐IMP SPECTによる検討
    榊原隆次, 内田佳孝, 石井一成, 数井裕光, 橋本正明, 石川正恒, 湯浅龍彦, 白井厚治, 服部孝道, 内山智之, 山西友典, PHONI Sin
    (一社)日本排尿機能学会, Oct. 2007, 日本排尿機能学会誌, 18(1) (1), 117 - 118, Japanese

  • 進行胃癌に合併した肺動脈腫瘍塞栓の1例
    河野 淳, 中林 美日, 杉村 和朗, 石井 一成, 宮本 直和, 福田 哲也
    (公社)日本医学放射線学会, Sep. 2007, 日本医学放射線学会秋季臨床大会抄録集, 43回, S463 - S463, Japanese

  • 当院にて経験したPopliteal Artery Entrapment Syndrome
    河野 淳, 石井 一成, 祖父江 慶太郎, 宮本 直和, 福田 哲也
    バイエル薬品(株), May 2007, 日独医報, 52(1) (1), 129 - 129, Japanese

  • 急性腎不全を来したI型大動脈解離による腎動脈狭窄に対してstentを留置した1例
    宮本 直和, 福田 哲也, 祖父江 慶太郎, 河野 淳, 吉川 俊紀, 石井 一成, 圓尾 文子, 向原 伸彦, 吉田 正人, 志田 力
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2007, IVR: Interventional Radiology, 22(2) (2), 267 - 267, Japanese

  • MRIによる早期アルツハイマー型認知症診断システムの開発
    石井 一成
    (一社)兵庫県医師会, Mar. 2007, 兵庫県医師会医学雑誌, 49(2) (2), 126 - 127, Japanese

  • Imaging diagnosis of idiopathic normal pressure hydrocephalus
    石井 一成
    自施設で三次元MRI検査を行った特発性正常圧水頭症(iNPH)20例とアルツハイマー病(AD)20例の画像所見を群間比較した。比較項目は[脳側室Evans Index(両側側脳室前角最大幅/その断面における頭蓋内腔最大幅(%))][シルビウス裂と高位円蓋部脳溝(外側前頭葉、内側前頭葉、外側頭頂葉、内側頭頂葉)の拡大程度][局所的脳溝のポケット状拡大の有無][cingulate sulcus signの有無]とした。脳側室Evans IndexはiNPH群のほうが有意に高値であった。シルビウス裂の拡大程度はiNPH群のほうが有意に高かった。高位円蓋部脳溝の拡大程度は、外側前頭葉では両群間に有意差を認めなかったが、内側前頭葉と外側・内側頭頂葉ではAD群のほうが有意に拡大程度が高く、iNPH群には狭小化がみられた。局所的脳溝のポケット状拡大はiNPH群で6例(30%)に認め、AD群には1例も認めなかった。cingulate sulcus signはiNPH群で15例(75%)、AD群で1例(5%)に認めた。
    金原出版(株), Mar. 2007, 臨床放射線, 52(3) (3), 449 - 457, Japanese

  • 脳統計学的画像診断法の発展とピットフォール
    石井 一成, 祖父江 慶太郎, 宮本 直和, 吉川 俊紀
    (公社)日本医学放射線学会, Feb. 2007, 日本医学放射線学会学術集会抄録集, 66回, S105 - S105, Japanese

  • 腎動脈狭窄に対する経皮的腎血管形成術 腎機能悪化予防についての検討
    祖父江 慶太郎, 宮本 直和, 福田 哲也, 吉川 俊紀, 石井 一成
    (公社)日本医学放射線学会, Feb. 2007, 日本医学放射線学会学術集会抄録集, 66回, S257 - S257, Japanese

  • 認知症をどう診るか? 認知症診療の実際 誌上ディベート アルツハイマー病の早期診断に有効なのはアミロイドイメージングか、脳代謝・血流画像か 脳代謝・血流画像であるとの立場から
    石井 一成
    (株)メディカルレビュー社, Jan. 2007, Cognition and Dementia, 6(1) (1), 74,4 - 78,4, Japanese

  • Urinary dysfunction and right frontal hypoperfusion in idiopathic normal pressure hydrocephalus; An [123I]-IMP SPECT study
    R. Sakakibara, Y. Uchida, K. Ishii, H. Kazui, M. Hashimoto, M. Ishikawa, T. Uchiyama, T. Yamamoto, H. Takahashi, K. Shirai, T. Hattori
    2007, NEUROUROLOGY AND URODYNAMICS, 26(5) (5), 612 - 613, English
    Summary international conference

  • レビー小体型認知症の診断におけるMIBG心筋シンチの有用性の検討
    嶋田 兼一, 石井 一成, 中村 佐智子, 寺島 明, 阪井 一雄, 尾崎 健一郎, 清水 光太郎, 大川 愼吾
    (一社)日本神経学会, Dec. 2006, 臨床神経学, 46(12) (12), 1004 - 1004, Japanese

  • 意味性痴呆における記憶障害の神経基盤
    西尾慶之, 石井一成, 数井裕光, 細貝良行, 博野信次, 森悦朗
    (一社)日本神経学会, Dec. 2006, 日本神経学会総会プログラム・抄録集, 46(12) (12), 1004 - 1004, Japanese

  • 河野 淳, 石井 一成, 祖父江 慶太郎, 宮本 直和, 金田 純子, 喜多 也寸志, 杉村 和朗
    (一社)日本核医学会, Nov. 2006, 核医学, 43(4) (4), 367 - 367, Japanese

  • 正常圧水頭症
    石井 一成
    30 Oct. 2006, 核医学 : 日本核医学会機関誌 : the Japanese journal of nuclear medicine, 43(3) (3), S100, Japanese

  • 予防と治療につながる脳核医学 正常圧水頭症
    石井 一成
    (一社)日本核医学会, Oct. 2006, 核医学, 43(3) (3), 144 - 144, Japanese

  • 軽症レビー小体型認知症とアルツハイマー病のFDG-PET全自動コンピューター補助診断
    河野 淳, 石井 一成, 祖父江 慶太郎, 宮本 直和, 坂本 攝, 杉村 和朗
    (一社)日本核医学会, Oct. 2006, 核医学, 43(3) (3), 242 - 243, Japanese

  • Comparison of morphologic and metabolic reduction in mild dementia with Lewy bodies and Alzheimer disease
    K. Ishii, T. Soma, A. K. Kono, K. Sofue, N. Miyamoto, A. Sakurai, K. Murase
    Sep. 2006, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 33, S295 - S295, English
    Summary international conference

  • 特発性脊椎硬膜外血腫の2例
    河野 淳, 藤井 正彦, 杉村 和朗, 祖父江 慶太郎, 宮本 直和, 石井 一成, 木村 英仁, 本岡 康彦, 川口 哲郎
    (公社)日本医学放射線学会, Sep. 2006, 日本医学放射線学会秋季臨床大会抄録集, 42回, S518 - S518, Japanese

  • TASCB・C型腸骨動脈病変に対する血管内治療とbypass術の比較
    宮本 直和, 福田 哲也, 祖父江 慶太郎, 河野 淳, 吉川 俊紀, 石井 一成, 杉村 和朗, 吉田 正人, 向原 伸彦, 志田 力
    (一社)日本脈管学会, Sep. 2006, 脈管学, 46(Suppl.) (Suppl.), S204 - S204, Japanese

  • 嶋田 兼一, 寺島 明, 石井 一成, 吉原 育男, 大川 慎吾
    (株)ワールドプランニング, Jun. 2006, 老年精神医学雑誌, 17(増刊I) (増刊I), 203 - 203, Japanese

  • 弓部大動脈置換術後,腕頭動脈吻合部仮性瘤に対してstent graft留置が有用であった1例
    宮本 直和, 福田 哲也, 河野 淳, 石井 一成, 井上 武, 吉田 正人, 大保 英文, 向原 伸彦, 志田 力
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2006, IVR: Interventional Radiology, 21(2) (2), 210 - 210, Japanese

  • 石井 一成
    【要旨】Mild cognitive impairment(MCI)の中から近い将来アルツハイマー病(AD)へ移行する症例(コンバーター)をいかに見つけだし介入するかが最近注目をあびてきている。これまでFDG-PETによる脳糖代謝画像を用いてMCIからADへのコンバーターを見つけだす手法が報告されてきたが、PETで得られた成果がSPECTに還元されることが期待できる。すなわちMCIの段階でADでみられる後部帯状回・楔前部、頭頂側頭連合野の代謝・血流低下がみられればその症例はADに移行することが予測される。また最近、画像統計解析法3D-SSPやSPMが臨床応用されるようになり、コンピュータ技術の発展とともに広く一般病院でも施行されるようになってきた。こういった背景を踏まえてMCIを対象としたアルツハイマー型痴呆の早期診断に関する研究Japan Cooperative SPECT Study on Assessment of MildImpairment of Cognitive Function(J-COSMIC)が現在多施設共同研究として進行している。この研究の目的は多施設共同研究にてMCIを対象としてアルツハイマー型痴呆の早期診断につき検討することである。画像統計解析法を概説した後、FDG-PETの所見を踏まえてSPECTからみたMCIとADの脳血流画像所見を解説し、またJ-COSMICを紹介した。
    認知神経科学会, Mar. 2006, 認知神経科学, 8(1) (1), 35 - 38, Japanese

  • MRIによる特発性正常圧水頭症の診断
    石井 一成, 河野 淳, 宮本 直和, 福田 哲也
    (公社)日本医学放射線学会, Feb. 2006, 日本医学放射線学会学術集会抄録集, 65回, S95 - S95, Japanese

  • 非閉塞性腸間膜虚血の検討
    河野 淳, 福田 哲也, 宮本 直和, 石井 一成
    (公社)日本医学放射線学会, Feb. 2006, 日本医学放射線学会学術集会抄録集, 65回, S159 - S159, Japanese

  • TASC B・C型腸骨動脈病変に対する血管内治療とbypass術におけるQOLの比較
    宮本 直和, 福田 哲也, 河野 淳, 石井 一成, 杉村 和朗
    (公社)日本医学放射線学会, Feb. 2006, 日本医学放射線学会学術集会抄録集, 65回, S331 - S332, Japanese

  • FDG-PETによるSCA3とOPCAの比較
    田畑 昌子, 東 靖人, 宮石 雅浩, 水谷 好志, 佐々木 将博, 石井 一成
    (一社)日本神経学会, Dec. 2005, 臨床神経学, 45(12) (12), 1167 - 1167, Japanese

  • 痴呆を伴うパーキンソン病のFDG-PETによる検討
    東 靖人, 田畑 昌子, 宮石 雅浩, 佐々木 将博, 水谷 好志, 石井 一成
    (一社)日本神経学会, Dec. 2005, 臨床神経学, 45(12) (12), 1184 - 1184, Japanese

  • Frontal-subcortical circuit disruption subsequent to upper pontine infarct
    Y Nishio, K Ishii, H Kazui, Y Hosokai, N Hirono, E Mori
    Nov. 2005, JOURNAL OF THE NEUROLOGICAL SCIENCES, 238, S518 - S519, English
    Summary international conference

  • 線条体黒質変性症のFDG-PETについて
    田畑 昌子, 宮石 雅浩, 東 靖人, 石井 一成
    (一社)日本神経学会, Oct. 2005, 臨床神経学, 45(10) (10), 779 - 779, Japanese

  • 本邦にて進行中のEBM trial SINPHONI
    石井 一成
    日本メジフィジックス(株), Oct. 2005, ブレイン・ファンクション・イメージング・カンファレンス記録集, (21) (21), 55 - 58, Japanese

  • Assessment of Parkinson disease with dementia by FDG-PET
    Y. Higashi, M. Miyaishi, M. Tabata, M. Sasaki, K. Ishii
    Sep. 2005, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 32, S186 - S186, English
    Summary international conference

  • 心臓MRIが診断に有用であった心膜欠損症の1例
    河野 淳, 石井 一成, 佐々木 弘喜, 宮本 直和, 福田 哲也
    バイエル薬品(株), Sep. 2005, 日独医報, 50(3) (3), 589 - 589, Japanese

  • 石井 一成
    早期アルツハイマー病(AD)の形態的変化をMRIで評価し,日常診療で可能なMRI早期診断法を開発した.発症年齢の違いによる脳萎縮部位の差の検討として初老期(65歳未満)発症AD患者30例,老年期(65歳以上)発症AD患者30例,それぞれの群に年齢をマッチさせた正常ボランティア各30例を対象とした.診断プログラム評価用として同様に初老期発症群,対照正常年齢群,老年期発症群,対照正常年齢群を各20例対象とした.灰白質濃度データを正常データベースの値と比較してZスコアを各脳のボクセル毎に算出し,ADと診断するプログラムを作成した.ROC解析でAzは初老期発症AD群0.9435,老年期発症AD群0.9018であった.初老期発症AD群では感度85%,特異度90.3%,老年期発症AD群では感度84.4%特異度80.2%であった
    (一社)神緑会, Aug. 2005, 神緑会学術誌, 21, 143 - 144, Japanese

  • 石井 一成
    神緑会, Aug. 2005, 神戸大学医学部神緑会学術誌, 21(21) (21), 143 - 144, Japanese

  • SPECTからみたMCIとアルツハイマー病
    石井 一成
    認知神経科学会, Jul. 2005, 認知神経科学, 7(2) (2), 135 - 135, Japanese

  • 弓部大動脈置換術後,腕頭動脈吻合部仮性瘤に対してstent graft留置が有用であった1例
    宮本 直和, 福田 哲也, 河野 淳, 石井 一成, 井上 武, 吉田 正人, 大保 英文, 向原 伸彦, 志田 力
    (一社)日本インターベンショナルラジオロジー学会, Jul. 2005, IVR: Interventional Radiology, 20(3) (3), 326 - 326, Japanese

  • Evaluation of Activation and Decommissioning of the Medical Compact Cyclotron
    ISHIMOTO Takeshi, KUBOTA Haruyuki, MORI Tetsuya, TERAKAWA Kimihito, TANI Kuniharu, ISHII Kazunari
    (公社)日本アイソトープ協会, Jun. 2005, Radioisotopes, 54(6) (6), 185 - 192, Japanese

  • 石井 一成
    (株)最新医学社, May 2005, 最新医学, 60(5) (5), 980 - 987, Japanese

  • 腸骨動脈慢性完全性閉塞に対する血管内治療の初期成績 Zp的困難例の解析を含めて
    福田 哲也, 杉本 幸司, 河野 淳, 佐々木 弘喜, 宮本 直和, 石井 一成, 杉村 和朗
    (公社)日本医学放射線学会, Feb. 2005, 日本医学放射線学会学術集会抄録集, 64回, S142 - S143, Japanese

  • TASC B・C型腸骨動脈病変に対する血管内治療に関する中期成績の検討
    宮本 直和, 福田 哲也, 河野 淳, 佐々木 弘喜, 石井 一成
    (公社)日本医学放射線学会, Feb. 2005, 日本医学放射線学会学術集会抄録集, 64回, S142 - S142, Japanese

  • MRI-VBMによるZ score画像を使用した軽症アルツハイマー病の診断
    石井 一成, 佐々木 弘喜, 河野 淳, 宮本 直和, 福田 哲也
    (公社)日本医学放射線学会, Feb. 2005, 日本医学放射線学会学術集会抄録集, 64回, S153 - S153, Japanese

  • 16列MDCTを用いた閉塞性動脈硬化症の術前評価 PTA術中血管内超音波所見と比較して
    佐々木 弘喜, 福田 哲也, 河野 淳, 宮本 直和, 石井 一成
    (公社)日本医学放射線学会, Feb. 2005, 日本医学放射線学会学術集会抄録集, 64回, S329 - S329, Japanese

  • 下肢急性動脈閉塞に対する経皮的血栓除去術の初期成績
    宮本 直和, 福田 哲也, 河野 淳, 佐々木 弘喜, 石井 一成, 吉田 正人, 大保 英文, 向原 伸彦, 志田 力
    (一社)日本インターベンショナルラジオロジー学会, Feb. 2005, IVR: Interventional Radiology, 20(2) (2), 214 - 215, Japanese

  • 特発性正常圧水頭症患者の海馬萎縮の検討
    橋本 衛, 数井 裕光, 石井 一成, 松本 圭司, 中野 葉子, 大川 慎吾, 森 悦朗
    (一社)日本神経学会, Dec. 2004, 臨床神経学, 44(12) (12), 1154 - 1154, Japanese

  • 脳のMRI診断338症例 成人発症の脱髄変性疾患
    大場 洋, 寺田 一志, 下野 太郎, 酒井 美緒, 森 墾, 藤井 裕太, 小川 敏英, 松尾 周也, 石亀 慶一, 和田 昭彦, 豊田 圭子, 石井 一成, 安藤 久美子, 高田 晃一, 石藏 礼一
    (株)学研メディカル秀潤社, Oct. 2004, 画像診断, 別冊(新版よくわかる脳MRI) (新版よくわかる脳MRI), 352 - 435, Japanese

  • 【痴呆性疾患における脳機能画像統計解析の臨床的有用性と信頼性】統計学的画像解析のOVERVIEW
    石井 一成
    金原出版(株), Oct. 2004, 臨床放射線, 49(10) (10), 1195 - 1201, Japanese

  • 腸骨動脈慢性完全閉塞性病変に対する血管内治療の初期成績
    福田 哲也, 石井 一成, 南 裕也, 吉田 正人, 大保 英文, 向原 伸彦, 志田 力
    (一社)日本脈管学会, Sep. 2004, 脈管学, 44(9) (9), 535 - 535, Japanese

  • 3D-SSPを用いたiNPH患者のIMP SPECT脳血流定性画像の検討
    佐々木 弘喜, 石井 一成, 河野 淳, 宮本 直和, 福田 哲也
    (一社)日本核医学会, Sep. 2004, 核医学, 41(3) (3), 348 - 348, Japanese

  • Stent-assisted Coil Embolizationにて救命しえた解離性椎骨動脈瘤破裂の1例
    河野 淳, 福田 哲也, 佐々木 弘喜, 多喜 雅人, 小島 芳夫, 石井 一成, 柴田 裕次, 岩倉 昌岐, 小松 英樹, 川口 哲郎, 杉本 幸司, 杉村 和朗, 廣田 省三
    (一社)日本インターベンショナルラジオロジー学会, Jul. 2004, IVR: Interventional Radiology, 19(3) (3), 307 - 307, Japanese

  • 総大腿動脈を含む外腸骨動脈狭窄・閉塞に対しての血管形成,ステント留置術
    福田 哲也, 杉本 幸司, 河野 淳, 佐々木 弘喜, 小島 芳夫, 石井 一成, 廣田 省三, 杉村 和朗
    (公社)日本医学放射線学会, Feb. 2004, 日本医学放射線学会雑誌, 64(2) (2), S114 - S114, Japanese

  • 閉塞性動脈硬化症患者における頸動脈超音波の有用性 術前スクリーニングとしての意義について
    河野 淳, 福田 哲也, 佐々木 弘喜, 小島 芳夫, 石井 一成
    (公社)日本医学放射線学会, Feb. 2004, 日本医学放射線学会雑誌, 64(2) (2), S230 - S230, Japanese

  • 初老期及び老年期発症軽症アルツハイマー病の灰白質萎縮部位の差 VBMによる検討
    石井 一成, 佐々木 弘喜, 河野 淳, 福田 哲也, 小島 芳夫
    (公社)日本医学放射線学会, Feb. 2004, 日本医学放射線学会雑誌, 64(2) (2), S322 - S322, Japanese

  • 失語を伴う進行性核上性麻痺の一例
    高月 容子, 中野 葉子, 石井 一成, 北田 香織, 田渕 正康, 森 悦朗
    日本神経心理学会, Dec. 2003, 神経心理学, 19(4) (4), 236 - 236, Japanese

  • 石井 一成, 森 悦朗
    (株)日本臨床社, Dec. 2003, 日本臨床, 61(増刊9 痴呆症学(1)) (増刊9 痴呆症学(1)), 473 - 478, Japanese

  • 失語を伴う進行性核上性麻痺の一例
    高月 容子, 中野 葉子, 石井 一成, 北田 香織, 田渕 正康, 森 悦朗
    日本神経心理学会, Dec. 2003, 神経心理学, 19(4) (4), 236 - 236, Japanese

  • 軽症アルツハイマー病における局所ブドウ糖代謝の1年間の継時的変化
    博野 信次, 橋本 衛, 石井 一成, 数井 裕光, 森 悦朗
    (一社)日本神経学会, Dec. 2003, 臨床神経学, 43(12) (12), 923 - 923, Japanese

  • クリニカルPETの現況について 脳 腫瘍,てんかん,痴呆
    石井 一成
    (公社)日本医学放射線学会, Sep. 2003, 日本医学放射線学会雑誌, 63(7) (7), S350 - S351, Japanese

  • 失語を伴う進行性核上性麻痺の一例
    高月 容子, 中野 葉子, 石井 一成, 北田 香織, 田渕 正康, 森 悦朗
    日本神経心理学会, Sep. 2003, 日本神経心理学会総会プログラム・予稿集, 27回, 136 - 136, Japanese

  • 早期アルツハイマー病の臨床診断 MCIのMRI及び核医学診断
    石井 一成
    (一社)日本認知症学会, Aug. 2003, Dementia Japan, 17(2) (2), 152 - 152, Japanese

  • 痴呆性疾患における脳機能画像統計解析の臨床的有用性と信頼性 統計学的画像解析のOVERVIEW
    石井 一成
    (一社)日本核医学会, Aug. 2003, 核医学, 40(3) (3), 277 - 277, Japanese

  • PET用院内サイクロトロン廃止時における放射線管理 兵庫県立姫路循環器病センターでの経験
    森 哲也, 石井 一成, 久保田 晴元, 石本 剛
    (一社)日本核医学会, Aug. 2003, 核医学, 40(3) (3), 388 - 388, Japanese

  • 軽症アルツハイマー病におけるFDG-PET及びMRI-VBMによる機能・形態変化の検討
    佐々木 弘喜, 石井 一成, 河野 淳, 福田 哲也
    (一社)日本核医学会, Aug. 2003, 核医学, 40(3) (3), 315 - 315, Japanese

  • 統計画像の臨床応用 Overview
    石井 一成
    日本メジフィジックス(株), Jul. 2003, ブレイン・ファンクション・イメージング・カンファレンス記録集, (18) (18), 33 - 36, Japanese

  • 石井 一成
    (一社)日本核医学会, May 2003, 核医学, 40(2) (2), 223 - 223, Japanese

  • Dementia and PET
    石井 一成
    (株)エムイー振興協会, Mar. 2003, 新医療, 30(3) (3), 104 - 107, Japanese

  • Clinical Dementia Rating(CDR)0.5患者の局所脳ブドウ糖代謝
    石井 一成, 小島 芳夫, 福田 哲也, 多喜 雅人
    (公社)日本医学放射線学会, Feb. 2003, 日本医学放射線学会雑誌, 63(2) (2), S165 - S165, Japanese

  • SENDA Michio, KUWABARA Yasuo, ITO Kengo, HAYASHIDA Kohei, OKAZAWA Hidehiko, UNO Kimiichi, NAKASHIMA Toshihiko, OKU Naohiko, TORIZUKA Kanji, OUCHI Yasuomi, ISHII Kazunari, ISHII Kenji, IKEDA Shunya, NASU Seiji, KAWABE Joji, ISHIZU Koichi, KATO Noriyuki
    A nation-wide survey was carried out on theFDG-PETscans for the diagnosis of dementia by theFDG-PETWorking Group organized by both the Japan Radioisotope Association and the Japanese Society of Nuclear Medicine. A total of 406 case reports were presented by 15PETcenters for one year. The purpose of thePETscans included (A) early diagnosis of Alzheimer-type Dementia (154 cases) and (B) differential diagnosis of degenerative dementia (144 cases), which was achieved by the PET scan in most cases. ThePETscan turned out to allow omittingCBF-SPECTscans. Since donepezil treatment of theAl-zheimerpatients prevents the progress of the disease and reduces the care cost, an economic evaluation was performed on the two-year projected cost and benefit ofFDG-PET.The reduction of the total cost by incorporatingPETinto the protocol was predicted to be 61 500 yen (A) and 13 700 yen (B) per person. The increase of the Quality Adjusted Life Year (QALY) was predicted to be 0.0442 (A) and 0.0137 (B) . Therefore, incorporation ofPETinto the clinical pass was shown to be an economically dominant. As the number of potential subjects for early diagnosis of dementia is estimated to be 9000 across the country every year, PET is expected to increase their quality of life equivalent to 398 intact persons per year while reducing the cost of health care by 554 million yen.
    Japan Radioisotope Association, 2003, RADIOISOTOPES, 52(11) (11), 585 - 598, Japanese

  • 急性期に治療し得たIII b型大動脈解離に合併した腎虚血の1例
    多喜 雅人, 福田 哲也, 奥野 晃章, 小島 芳夫, 石井 一成, 向原 伸彦, 廣田 省三, 杉本 幸司, 杉村 和朗
    (一社)日本インターベンショナルラジオロジー学会, Jan. 2003, IVR: Interventional Radiology, 18(1) (1), 67 - 67, Japanese

  • 脳血流測定による診断と治療のモニタリング 痴呆診断において脳血流量測定の必要性はあるか?
    石井 一成
    日本メジフィジックス(株), Nov. 2002, ブレイン・ファンクション・イメージング・カンファレンス記録集, (17) (17), 37 - 42, Japanese

  • Coil塞栓術を施行した骨髄線維症に合併した脾動脈瘤の1例
    奥野 晃章, 福田 哲也, 多喜 雅人, 小島 芳夫, 石井 一成, 杉本 幸司, 藤井 正彦, 杉村 和朗, 廣田 省三
    (公社)日本医学放射線学会, Oct. 2002, 日本医学放射線学会雑誌, 62(12) (12), 720 - 720, Japanese

  • 生化学画像の臨床的意義 血流イメージングから分子イメージングへ 痴呆におけるFDGイメージング
    石井 一成
    (一社)日本核医学会, Sep. 2002, 核医学, 39(3) (3), 258 - 258, Japanese

  • 石井 一成, 坂本 攝, 松井 美詠子
    統計学的手法を用いて局所脳ブドウ糖代謝PET画像を算出する方法の開発を行った.本法は,動脈血入力関数の推定というステップを省略し,データベースを構築し,重回帰分析法により投与量,血漿ブドウ糖濃度,体表面積の3つの因数から直接,局所脳ブドウ糖代謝率(rCMRglc)を推定するものである.18F-fluorodeoxyglucose-positron emission tomographyを施行した連続する30例と,別の連続する30例を用いて理論rCMRglcを算出し,実測値rCMRglcとの相関を評価したところ,相関係数は0.842と良好な結果が得られた.以上より,本法は採血を行わない非侵襲的CMRglc定量法として臨床応用可能と考えられた
    (一社)神緑会, Aug. 2002, 神緑会学術誌, 18(18) (18), 101 - 102, Japanese

  • 【痴呆の画像診断 形態と機能からのアプローチ】PET
    石井 一成
    金原出版(株), Jul. 2002, 臨床放射線, 47(7) (7), 885 - 893, Japanese

  • Noninvasive quantification of cerebral glucose metabolism using multiple regression analysis method without arterial blood sampling.
    S Sakamoto, K Ishii, K Hosaka, T Mori, M Sasaki, M Senda
    May 2002, JOURNAL OF NUCLEAR MEDICINE, 43(5) (5), 237P - 237P, English
    Summary international conference

  • Comparison of F-18-FDG-PET and I-123-IMP-SPECT findings in dementia with Lewy bodies.
    K Hosaka, K Ishii, M Matsui, M Sasaki, T Mori, E Mori, K Sugimura
    May 2002, JOURNAL OF NUCLEAR MEDICINE, 43(5) (5), 255P - 255P, English
    Summary international conference

  • 【ここまでわかる脳機能画像 現状と展望】PET/SPECT アルツハイマー病の核医学診断
    石井 一成
    PET/SPECTを用いた核医学診断は,アルツハイマー病(AD)の診断において,形態画像では得ることのできない血流・代謝といった機能画像を提供し,早期診断・鑑別診断に非常に有用である.ADに特徴的な所見は頭頂側頭連合野,後部帯状回の血流・代謝低下で,一次感覚運動野,一次視覚野,基底核,視床,橋,小脳の血流・代謝は比較的温存される
    (株)学研メディカル秀潤社, Apr. 2002, 画像診断, 22(5) (5), 500 - 508, Japanese

  • 石井 一成
    非侵襲的に生体機能を見ることができるPETは,X線CTやMRIといった形態診断ではつかめないグルコース代謝・アミノ酸代謝機能画像を提供する.臨床場面においては,特にFDG-PETががんの診断・治療効果判定の分野において大きな威力を発揮し,クリニカルPETを牽引している.機能画像が臨床に貢献するクリニカルPETの時代が到来した
    (株)最新医学社, Mar. 2002, 最新医学, 57(3) (3), 462 - 467, Japanese

  • 顕著なclosing-in現象を示したアルツハイマー型痴呆の一例
    小久保 香江, 今村 徹, 石井 一成, 森 悦朗
    日本神経心理学会, Dec. 2001, 神経心理学, 17(4) (4), 281 - 281, Japanese

  • 【放射線医学の新展開 到達点と将来展望】核医学 中枢神経領域の核医学
    石井 一成
    (株)現代医療社, Oct. 2001, 現代医療, 33(10) (10), 2549 - 2554, Japanese

  • Quantitative analysis of spatio-temporal distribution of spatial attention in a patient with Alzheimer disease
    MATSUMOTO Eriko, IMAMURA Toru, ISHII Kazunari, MORI Etsuro, MIYAUCHI Satoru
    25 Sep. 2001, 神経心理学 : Japanese journal of neuropsychology, 17(3) (3), 201 - 212, Japanese

  • 顕著なClosing-in現象を示したアルツハイマー型痴呆の一例
    小久保 香江, 今村 徹, 石井 一成, 森 悦朗
    日本神経心理学会, Aug. 2001, 日本神経心理学会総会プログラム・予稿集, 25回, 126 - 126, Japanese

  • Difference of metabolic impairment between early and late onset types of Alzheimer's disease.
    S Sakamoto, K Ishii, M Matsui, K Hosaka, T Mori, M Sasaki, E Mori
    May 2001, JOURNAL OF NUCLEAR MEDICINE, 42(5) (5), 13P - 14P, English
    Summary international conference

  • Anatomic validation of spatial normalization methods for FDG-PET: SPM and NEUROSTAT.
    K Hosaka, S Sakamoto, K Ishii, M Senda, N Sadato, H Fukuda, T Kato, K Sugimura
    May 2001, JOURNAL OF NUCLEAR MEDICINE, 42(5) (5), 216P - 216P, English
    Summary international conference

  • 【内科医のためのアルツハイマー病 診断と治療の最前線】アルツハイマー病の診断 画像で診断するアルツハイマー病
    石井 一成
    MRIは脳の萎縮を評価し,形態的にアルツハイマー病の診断に寄与する.又,MRIは脳血管性障害など他の痴呆を起こす疾患の除外診断に必須である.SPECT,PETは機能画像を提供し,早期診断,確定診断,経過観察に有用である.SPECT,PETは,アルツハイマー病に特徴的な血流・代謝低下パターンを見い出し,アルツハイマー病類似疾患の血流・代謝低下パターンを把握し鑑別を行うことができる
    (株)新興医学出版社, Apr. 2001, Modern Physician, 21(4) (4), 415 - 419, Japanese

  • 坂本 攝, 松井 美詠子, 佐々木 將博, 森 哲也, 石井 一成, 森 悦朗
    (一社)日本核医学会, Mar. 2001, 核医学, 38(2) (2), 168 - 169, Japanese

  • 左一側性視床polar artery領域梗塞の症候学的・神経放射線学的検討
    橋本 衛, 博野 信次, 谷向 知, 今村 徹, 埴原 秋児, 数井 裕光, 石井 一成, 坂本 攝, 高月 容子, 森 悦朗
    (一社)日本神経学会, Dec. 2000, 臨床神経学, 40(12) (12), 1325 - 1325, Japanese

  • 坂本 攝, 松井 美詠子, 佐々木 將博, 森 哲也, 保坂 加代, 杉村 和朗, 石井 一成
    (一社)日本核医学会, Sep. 2000, 核医学, 37(5) (5), 543 - 543, Japanese

  • Difference in detectability of hypomatabolic regions in Alzheimer's disease. Comparison between early and ordinary scans of FDG-PET.
    S Sakamoto, K Ishii, M Matsui, M Sasaki, T Mori, K Hosaka
    May 2000, JOURNAL OF NUCLEAR MEDICINE, 41(5) (5), 218P - 218P, English
    Summary international conference

  • 【アルツハイマー病をめぐる最近の諸問題】アルツハイマー病の機能画像 Positron Emission Tomography(PET),Single Photon Emission Computed Tomography(SPECT),fMRIについて
    坂本 攝, 石井 一成, 松井 美詠子
    (株)ライフメディコム, Mar. 2000, カレントテラピー, 18(4) (4), 610 - 613, Japanese

  • アルツハイマー型痴呆の経過中の脳体積変化 頭部MRIの三次元立体表示と体積測定による検討
    松井 美詠子, 坂本 攝, 石井 一成, 北垣 一, 畑 豊, 杉村 和朗
    (公社)日本医学放射線学会, Feb. 2000, 日本医学放射線学会雑誌, 60(2) (2), S260 - S260, Japanese

  • 反復する幻視を呈しPETで後頭葉に局所脳糖代謝低下を認めた1例
    今村 徹, 埴原 秋児, 森 悦朗, 石井 一成
    (一社)日本神経学会, Oct. 1999, 臨床神経学, 39(10) (10), 1083 - 1083, Japanese

  • 松井 美詠子, 石井 一成, 佐々木 將博, 森 哲也, 坂井 洋登, 北垣 一
    (一社)日本核医学会, Aug. 1999, 核医学, 36(6) (6), 603 - 603, Japanese

  • 痴呆性疾患の核医学診断(PET)
    石井 一成
    (株)日本医事新報社, Jul. 1999, 日本医事新報, (3925) (3925), 33 - 36, Japanese

  • Timetable-like daily living and stereotyped roaming after a right hemispheric infarction
    IMAMURA Toru, FUJIMORI Misato, ISHII Kazunari, MORI Etsuro, IKEDA Manabu
    73歳右利き男性.1年前の左上下肢麻痺発作後,根気がなく落ち着きがないといった症状が出現し,また食事,散歩,入浴,戸締まりなどを自分の決めた時刻に毎日行うようになった.散歩は毎日午前10時30分から決まった経路で行うようになった.神経心理学的には構成障害,視空間認知障害,軽度の左半側空間無視と共に,間代性及び意図性保続,運動性反応抑制課題の障害が認められた.約1ヵ月半の入院中,入院前の時刻表的生活と常同的周遊は速やかに消失したが,脱抑制行動と常同行動が明らかで,新たな時刻表的行動が形成された.MRIで右前頭頭頂葉皮質下白質と左頭頂葉皮質に陳旧性の梗塞巣が認められ,PETでは,梗塞巣に一致する部位に加えて右前頭葉〜側頭葉前部皮質と右側頭頭頂葉皮質に局所脳血流低下がみられた.本症例では右半球に病巣の主座を持つ虚血性脳血管障害後,少なくとも約1年間持続的に観察された
    日本神経心理学会, Jun. 1999, 神経心理学, 15(2) (2), 124 - 131, Japanese

  • Regional cerebral blood flow difference between dementia with Lewy bodies and Alzheimer's disease.
    K Ishii, S Yamaji, H Kitagaki, T Imamura, N Hirono, E Mori
    May 1999, JOURNAL OF NUCLEAR MEDICINE, 40(5) (5), 268P - 268P, English
    Summary international conference

  • 意味記憶の神経基盤 PETを用いたアルツハイマー病患者の検討
    博野 信次, 森 悦朗, 石井 一成
    認知神経科学会, Apr. 1999, 認知神経科学, 1(1) (1), 81 - 83, Japanese

  • 皮質基底核変性症の局所脳糖代謝
    石井 一成, 坂本 攝, 山路 滋, 林 直子, 北垣 一
    (公社)日本医学放射線学会, Feb. 1999, 日本医学放射線学会雑誌, 59(2) (2), S153 - S153, Japanese

  • 頭部MRIの三次元立体表示と体積測定による皮質基底核変性症とアルツハイマー病の診断
    北垣 一, 石井 一成, 畑 豊
    (公社)日本医学放射線学会, Feb. 1999, 日本医学放射線学会雑誌, 59(2) (2), S228 - S228, Japanese

  • Disinhibited Behavior after a Right Temporal Lobe Infarction
    MANO Keiko, IMAMURA Toru, FUJIMORI Misato, ISHII Kazunari, MORI Etsuro
    77歳女,行動面で脱抑制と社会性の低下,検査場面で前頭葉課題での障害がみられた右側頭葉梗塞の一例を報告した.7年前より脱抑制行動と社会性の低下がみられ,問題解決課題でのルールの無視,Utilization behavior,考え不精,脱抑制行動が目立った.MRIで右側頭頭頂葉に陳旧性の梗塞巣が,PETでは,梗塞巣に加えて右側頭葉底面に局所脳酸素代謝低下がみられた.本症例の行動神経学的症状は前頭葉眼窩面症候群に類似していたが,MRI,PETでは前頭葉に異常は認められなかった.前頭葉眼窩面と側頭葉底面は共に旧皮質に属し,情動的,知的行動を選択的に抑制ないし解放する機能を持つ可能性が示唆されている.本症例の症状発現には,右側頭葉底面の機能低下が関与している可能性がある
    日本神経心理学会, Dec. 1998, 神経心理学, 14(4) (4), 233 - 241, Japanese

  • 【胸部孤立性陰影エンサイクロペディア】血管原性結節 気管支動脈瘤
    石井 一成
    克誠堂出版(株), Nov. 1998, 日本胸部臨床, 57(増刊) (増刊), S42 - S43, Japanese

  • 石井 一成, 佐々木 將博, 山路 滋, 北垣 一, 坂井 洋登, 紀田 利, 池尻 義隆, 森 悦朗
    (一社)日本核医学会, Nov. 1998, 核医学, 35(9) (9), 981 - 981, Japanese

  • 123I-IMP SPECt脳血流画像を用いたレヴィー小体を伴う痴呆とアルツハイマー病の鑑別診断
    森 悦朗, 石井 一成, 北垣 一, 今村 徹, 博野 信次
    (一社)日本認知症学会, Sep. 1998, Dementia Japan, 12(2) (2), 140 - 140, Japanese

  • Lewy小体をともなう痴呆(Dementia with Lewy bodies:DLB)における幻視と局所脳糖代謝との関係
    今村 徹, 石井 一成, 博野 信次, 橋本 衛, 谷向 知, 数井 裕光, 埴原 秋児, 森 悦朗
    日本認知症学会, Sep. 1998, Dementia Japan, 12(2) (2), 144 - 144, Japanese

  • 石井 一成, 山路 滋, 佐々木 將博, 紀田 利, 北垣 一
    (一社)日本核医学会, Aug. 1998, 核医学, 35(7) (7), 542 - 542, Japanese

  • H Kitagaki, E Mori, S Yamaji, K Ishii, N Hirono, S Kobashi, Y Hata
    Radiological Society of North America Inc., Aug. 1998, Radiology, 208(2) (2), 431 - 9, English, International magazine
    [Refereed]

  • Standardized uptake value to assess cerebral glucose metabolism in Alzheimer's disease.
    S Yamaji, K Ishii, M Sasaki, H Kitagaki, S Sakamoto, E Mori
    May 1998, JOURNAL OF NUCLEAR MEDICINE, 39(5) (5), 163P - 163P, English
    Summary international conference

  • Frontotemporal dementiaの局所脳糖代謝
    石井 一成
    (公社)日本医学放射線学会, Feb. 1998, 日本医学放射線学会雑誌, 58(2) (2), S42 - S42, Japanese

  • Cerebellar metabolic reduction in Alzheimer's disease and data normalization - Reply
    K Ishii, S Yamaji, E Mori
    Feb. 1998, JOURNAL OF NUCLEAR MEDICINE, 39(2) (2), 375 - 376, English
    Report scientific journal

  • Delusions of oral parasitosis.
    K Maeda, Y Yamamoto, M Yasuda, K Ishii
    Jan. 1998, Progress in neuro-psychopharmacology & biological psychiatry, 22(1) (1), 243 - 8, English, International magazine
    [Refereed]

  • Fumihiko Yasuno, Toru Imamura, Nobutsugu Hirono, Kazunari Ishii, Masahiro Sasaki, Yoshitaka Ikejiri, Mamoru Hashimoto, Tatsuo Shimomura, Hikari Yamashita, Etsuro Mori
    S. Karger AG, 1998, Dementia and Geriatric Cognitive Disorders, 9(2) (2), 63 - 67, English

  • 頭部MRIの立体表示と体積測定による変性性痴呆性疾患の診断
    北垣 一, 山路 滋, 石井 一成, 森 悦朗, 小橋 昌司, 畑 豊
    (一社)日本磁気共鳴医学会, Sep. 1997, 日本磁気共鳴医学会雑誌, 17(Suppl.) (Suppl.), 103 - 103, Japanese

  • 石井 一成
    (一社)日本核医学会, Aug. 1997, 核医学, 34(8) (8), 660 - 660, Japanese

  • アルツハイマー病において海馬血流量は低下しない!?
    石井 一成
    (公社)日本医学放射線学会, Feb. 1997, 日本医学放射線学会雑誌, 57(2) (2), S72 - S72, Japanese

  • Exacerbation of Palilalia with Trihexyphenidyl in Progressive Supranuclear Palsy
    SATO Mutsumi, IMAMURA Toru, MORI Etsuro, ISHII Kazunari, TSUTSUMI Akira
    25 Sep. 1996, 神経心理学 : Japanese journal of neuropsychology, 12(3) (3), 197 - 203, Japanese

  • Alzheimer型痴呆の局所脳酸素摂取率
    石井 一成
    断層映像研究会, Mar. 1995, 断層映像研究会雑誌, 21(2) (2), 178 - 178, Japanese

  • Alzheimer型痴呆脳の循環酸素代謝 PETガススタディによる検討
    坂本 攝, 石井 一成, 北垣 一, 佐々木 將博, 紀田 利, 山路 滋, 河野 通雄
    (一社)日本核医学会, Jul. 1994, 核医学, 31(7) (7), 713 - 713, Japanese

  • 痴呆患者のInteruncal Distance MRIによる検討
    石井 一成
    (公社)日本医学放射線学会, Mar. 1994, 日本医学放射線学会雑誌, 54(3) (3), 337 - 337, Japanese

  • NONINVASIVE THYMOMA IN A 15-YEAR-OLD GIRL - CT FINDINGS
    K ISHII, M KONO, K MAEDA
    Apr. 1993, AMERICAN JOURNAL OF ROENTGENOLOGY, 160(4) (4), 894 - 895, English
    Report scientific journal

  • 成人にて発見された巨大重複腸管嚢腫の1例
    石井 一成, 前田 一憲, 鷲尾 哲郎
    金原出版(株), Jun. 1992, 臨床放射線, 37(6) (6), 717 - 720, Japanese

  • MR appearance of a retained surgical sponge [8]
    K. Ishii, K. Maeda, M. Kono
    1992, American Journal of Roentgenology, 158(2) (2), 460, English
    Report scientific journal

  • 胸部ガーゼ腫のMRI
    石井 一成
    (一社)国立医療学会, Oct. 1991, 医療, 45(増刊) (増刊), 593 - 593, Japanese

  • 平井 宏和, 山崎 克人, 山路 滋, 野村 曜子, 石井 一成, 北垣 一, 田中 豊, 白坂 今日子, 井上 善夫, 河野 通雄
    (一社)日本核医学会, Aug. 1991, 核医学, 28(8) (8), 889 - 889, Japanese

  • 野村 曜子, 山崎 克人, 山路 滋, 平井 宏和, 石井 一成, 北垣 一, 田中 豊, 白坂 今日子, 井上 善夫, 河野 通雄
    (一社)日本核医学会, Aug. 1991, 核医学, 28(8) (8), 906 - 906, Japanese

  • 山路 滋, 山崎 克人, 野村 曜子, 平井 宏和, 石井 一成, 北垣 一, 田中 豊, 白坂 今日子, 井上 善夫, 河野 通雄
    (一社)日本核医学会, Aug. 1991, 核医学, 28(8) (8), 908 - 908, Japanese

  • 気管支動脈瘤の1例
    石井 一成, 長谷川 義記, 前田 一憲
    65歳女,持続する血痰を主訴とした患者の気管支動脈造影で偶然に発見された
    克誠堂出版(株), Aug. 1991, 日本胸部臨床, 50(8) (8), 677 - 680, Japanese

  • ISHII Kazunari, HASEGAWA Yoshiki, MAEDA Kazunori, NAKAHARA Yukiko, NAKAHARA Yasuharu, KONO Michio
    The Japanese Society of Gastroenterology, Jul. 1991, Nippon Shokakibyo Gakkai Zasshi, 88(7) (7), 1454 - 1458, Japanese

  • 石井 一成, 前田 一憲, 西平 友彦
    (株)医学書院, Jun. 1991, 胃と腸, 26(6) (6), 693 - 696, Japanese

  • 小児縦隔腫瘍のCTおよびMRI
    石井 一成
    (一社)国立医療学会, Oct. 1990, 医療, 44(増刊) (増刊), 290 - 290, Japanese

  • 石井 一成, 吉田 裕, 松井 律夫
    金原出版(株), Sep. 1990, 臨床放射線, 35(9) (9), 1021 - 1026, Japanese

  • 盲腸膜様閉鎖の1例
    石井 一成
    (公社)日本医学放射線学会, Jun. 1990, 日本医学放射線学会雑誌, 50(6) (6), 710 - 710, Japanese

■ Books And Other Publications
  • 症候学から見極める認知症
    石井一成
    Contributor, 認知症におけるPET画像診断up to date, 新興医学出版社, Jan. 2024

  • Molecular Imaging of Neurodegenerative Disorders
    Kazunari Ishii
    Contributor, 195-206, Springer, 2023

  • 胸部画像診断の勘ドコロNEO
    高橋, 雅士
    Contributor, 胸部病変とPET, メジカルビュー社, Jan. 2023, Japanese, ISBN: 9784758321037

  • Molecular Imaging of Neurodegenerative Disorders
    Kazunari Ishii
    Contributor, 304-313, Springer, 2023, ISBN: 9783031350979

  • 画像診断ガイドライン
    日本医学放射線学会
    Contributor, アルツハイマー病の診断においてMRIと脳血流SPECTは推奨されるか? pp 60-62., 金原出版, Sep. 2021, Japanese, ISBN: 9784307071239

  • 即戦力が身につく脳の画像診断
    三木 幸雄, 山田 惠
    Contributor, 脳脊髄液関連疾患 pp40,75,110,226,268, メディカル・サイエンス・インターナショナル, Apr. 2021, Japanese, ISBN: 9784815730147

  • よくわかる脳MRI
    青木 茂樹, 相田 典子, 井田 正博, 大場 洋
    Contributor, Lewy小体型認知症,認知症を伴うパーキンソン病. pp544-545, 特発性正常圧水頭症. pp562-563, 学研メディカル秀潤社,学研プラス (発売), Jun. 2020, Japanese, ISBN: 9784780909722

  • MRI of the brain
    細矢 貴亮, 興梠 征典, 三木 幸雄, 山田 惠
    Contributor, 脳脊髄液の循環動態とMRI.,pp749-752; 水頭症, pp753-761, メディカル・サイエンス・インターナショナル, Apr. 2015, Japanese, ISBN: 9784895928120

  • iNPH : idiopathic normal pressure hydrocephalus
    石川 正恒, 森 悦朗, 新井 一
    Contributor, VIII 特発性正常圧水頭症の診断 8. MRI・CT所見. ｐp101-108, 金芳堂, Oct. 2014, Japanese, ISBN: 9784765316170

  • 画像診断ガイドライン
    日本医学放射線学会, 日本放射線科専門医会・医会
    Contributor, アルツハイマー病の診断にどのような画像検査を推奨するか？ pp 95-97, 特発性正常圧水頭症にはどのような画像検査が有用か？ pp 98-99, 金原出版, Jul. 2013, Japanese, ISBN: 9784307070935

■ Lectures, oral presentations, etc.
  • Development of a specialized image reconstruction technique for dedicated breast positron emission tomography.
    K. Hanaoka, S. Watanabe, D. Ishikawa-Morimoto, Y. Yamakawa, T. Kobayashi, A. Ohtani, S. Kumakawa, T. Ito, Y. Komoike, H. Kaida, K. Ishii
    EANM 2023 Congress, Sep. 2023, English
    Oral presentation

  • 生成系AIを用いた読影医によるアノテーション不要なFDG-PET/CT像の肺病変強調手法.
    大谷和暉, 根本充貴, 甲斐田勇人, 瀬川 新, 木村裕一, 永岡 隆, 三上勝大, 山田誉大, 花岡宏平, 槌谷達也, 北島一宏, 石井一成
    第5回 日本核医学会近畿支部会, Jul. 2023, Japanese
    Oral presentation

  • アミロイドPET撮像判断のための生成系AIによるFDG画像からのアミロイド画像合成の検討.
    本田実沙, 山田誉大, 永岡 隆, 三上勝大, 根本充貴, 花岡宏平, 甲斐田勇人, 石井一成, 木村裕一
    第5回 日本核医学会近畿支部会, Jul. 2023, Japanese
    Oral presentation

  • 乳房PET検査のための再構成手法.
    花岡宏平, 石川大介, 山川善之, 小林哲哉, 大谷 篤, 熊川志帆, 位藤俊一, 菰池佳史, 山田誉大, 甲斐田勇人, 石井一成
    第5回 日本核医学会近畿支部会, Jul. 2023, Japanese
    Oral presentation

  • Validation of a Glucose Metabolism to Tau Deposition Ratio Image in the Alzheimer’s Continuum.
    K. Ishii, T. Yamada, K. Hanaoka, H. Kaida, K. Ishii, T. Kato, A. Nakamura, BATON Study Group
    2023 SNMMI Annual Meeting, Jun. 2023, English
    Poster presentation

  • Initial study of an algorithm for estimating the presence of amyloid accumulation from 18F-FDG PET images using machine learning.
    T. Yamada, K. Hanaoka, Hayato Kaida, K. Ishii
    Brain & BrainPET 2023, Jun. 2023, English
    Poster presentation

  • Acceleration Motion Compensation Diffusion-weighted Imaging For Aortitis: Phantom and Clinical Studies.
    Hyodo T, Nozaki Y, Kaida H, Morimoto-Ishikawa D, Ueda Y, Ito M, Yasuda N, Fukushima H, Yamamoto A, Ishii K
    2022 RSNA, Nov. 2022, English
    Poster presentation

  • Quantitative Evaluation of Noncontrast Magnetic Resonance Enterography for Active Inflammation in Crohn's Disease Using Native T1 and T2 Mapping.
    Morimoto-Ishikawa D, Hyodo T, Komeda Y, Fukushima H, Ito M, Ueda Y, Saito S, Ishii K
    2022 RSNA, Nov. 2022, English
    Oral presentation

  • 認知症診療における核医学検査の現状と将来展望 〜アミロイド・タウイメージングを中心に〜
    石井一成
    第30回 北海道脳PET・SPECT研究会, Nov. 2022
    [Invited]
    Public discourse

  • 地域在住高齢者における脳室・くも膜下腔脳脊髄液体積の加齢性変化とその臨床的意義.
    日髙洋介, 橋本 衛, 末廣 聖, 福原竜治, 石川智久, 津野田尚子, 小山明日香, 本田和揮, 宮川雄介, 吉浦和宏, 朴 秀賢, 石井一成, 池田 学, 竹林 実
    第44回日本生物学的精神医学会年会、第32回日本臨床精神神経薬理学会年会、第52回日本神経精神薬理学会年会、第6回日本精神薬学会総会・学術集会の4学会合同年会, Nov. 2022

  • Fibrolamellar Hepatocellular Carcinomaの一例.
    山田 穣, 浜川岳文, 藤谷哲也, 浦瀬篤史, 上月瞭平, 小寺 卓, 鈴木絢子, 平山 歩, 石田愛, 若林雄一, 関 紳一郎, 山田誉大, 松久保祐子, 任 誠雲, 兵頭朋子, 甲斐田勇人, 小塚健倫, 鶴﨑正勝, 石井一成
    第332回 日本医学放射線学会関西地方会, Oct. 2022

  • Study for detecting pulmonary nodules on FDG-PET/CT images with training small dataset.
    A. Segawa, M. Nemoto, H. Kaida, Y, Kimura, T. Nagaoka, H. Yamaguti, Y. Nakamae, T. Yamada, K. Hanaoka, K. Kitajima, T. Tsuchitani, K. Ishii
    The 13th Congress of the World Federation of Nuclear Medicine and Biology

  • Evaluation on applicability of generative adversarial network to synthesize training images for AI-based computer aided diagnostic algorithm to dementia.
    A.Watanabe, T. Yamada, T. Nagaoka, M. Nemoto, H. Watabe, M. Ibaraki, K. Matsubara, K. Hanaoka, K. Ishii, Y. Kimura
    The 13th Congress of the World Federation of Nuclear Medicine and Biology

  • Detection of Bone;Metastasis on;FDG-PET/CT Images using;Multi-step Anomaly Voxel Detection;Local Patch analysis with;Unsupervised Deep Features;Image Textures
    H. Yamaguchi, M. Nemoto, H. Kaida, Y. Kimura, T. Nagaoka, T. Yamada, K. Hanaoka, K. Kitajima, T. Tsuchitani, K. Ishii
    The 13th Congress of the World Federation of Nuclear Medicine and Biology

  • Predicting the prognosis in tongue cancer patients using harmonized 18F-FDG PETCT parameters. A multicenter study.
    H. Kaida, K. Kitajima, T. Sekine, K. Ito, H. Daisaki, T. Kimura, A. Enomoto, N. Otsuki, K. Ishii
    The 13th Congress of the World Federation of Nuclear Medicine and Biology, Sep. 2022

  • アミロイドイメージングの現状と展望 〜臨床の立場から〜
    石井一成
    第42回 日本核医学技術学会総会学術大会, Sep. 2022
    [Invited]
    Nominated symposium

  • High performance dedicated Head PET scanner for Diagnosis of Dementia.
    Kazunari Ishii
    The 13th Congress of the World Federation of Nuclear Medicine and Biology, Sep. 2022, English
    Public discourse

  • Amyloid PET imaging alone is not sufficient to diagnose dementia
    Kazunari Ishii
    The 13th Congress of the World Federation of Nuclear Medicine and Biology, Sep. 2022, English
    [Invited]
    Public discourse

  • Neuroimaging in dementia: Up-to-date.
    Kazunari Ishii
    The Asia Oceania Congress of Nuclear Medicine and Biology 2022, Sep. 2022, English
    [Invited]
    Others

  • 急性膵炎後のWONに対する画像診断および経皮的ドレナージの役割.
    上月瞭平, 鶴﨑正勝, 浦瀬篤史, 小寺 卓, 平山 歩, 石井一成, 大本俊介, 竹中 完, 工藤正俊
    第58回 日本医学放射線学会秋季臨床大会

  • 私とiNPH一過去・現在・未来一
    石井一成
    公開シンポジウム「特発性正常圧水頭症(iNPH)対策の課題と展望~治療で改善できる認知症へのフォーカス~」, Aug. 2022
    [Invited]
    Public discourse

  • 難治性直腸瘻に対する経皮的瘻孔閉鎖術
    鶴崎正勝, 小寺 卓, 上月瞭平, 浦瀬篤史, 平山 歩, 石井一成
    第7回 日本穿刺ドレナージ研究会, Jul. 2022

  • 肝内外の多発動脈-門脈瘻による門脈圧亢進症に対しIVRを施行した1例.
    浦瀬篤司, 鶴崎正勝, 小寺 卓, 上月瞭平, 平山 歩, 石井一成
    第71回 関西IVR研究会, Jul. 2022

  • 体幹部コイル塞栓術におけるAZUR soft 3Dの初期経験.
    小寺 卓, 鶴崎正勝, 上月瞭平, 浦瀬篤史, 平山 歩, 石井一成
    第71回 関西IVR研究会, Jul. 2022

  • FDG-PET/CT で集積を認めた膵臓アミロイドーシスの⼀例.
    甲斐田勇人, 山田 穣, 関 紳一郎, 松久保祐子, 任 誠雲, 花岡宏平, 山田誉大, 兵頭朋子, 鶴崎正勝, 細野 眞, 石井一成
    第4回 日本核医学会近畿支部会, Jul. 2022

  • 認知症診療における核医学検査の活用〜アミロイド・タウイメージングを含む最新の知見と展望〜
    石井一成
    長崎ニューロイメージングカンファレンス, Jun. 2022
    [Invited]

  • Comparison of lesion detectability of dedicated breast PET and whole-body PET/CT.
    K. Hanaoka, S. Watanabe, D. Morimoto-Ishikawa, N. Ueno, A. Ohtani, Y. Yamakawa, S. Minagawa, T. Mizuta, H. Kaida, T. Itoh, Y. Komoike, K. Ishii
    SNMMI 2022 Annual Meeting

  • Comparison between the μ-maps of different PET tracers: 18F-FDG and 18F-flutemetamol, generated by the attenuation correction method without external radiation source
    T. Yamada, K. Hanaoka, Y. Yamakawa, S. Minagawa, A. Ohtani, T. Mizuta, H. Kaida, K. Ishii
    SNMMI 2022 Annual Meeting, English
    Poster presentation

  • Transcatheter coil embolization of splenic artery aneurysms: technique and midterm follow-up.
    M. Tsurusaki, I. Numoto, N. Ishida, A. Urase, R. Kozuki, T. Kotera, K. Ishii, T. Oda
    第51回 日本IVR学会総会, Jun. 2022

  • Robustness of a U-net model for different image processing types in segmentation of the mammary gland region.
    M. Yamamuro, Y. Asai, N. Hashimoto, N. Yasuda, H. Kimura, T. Yamada, M. Nemoto, Y. Kimura, H. Handa, H. Yoshida, K. Abe, M. Tada, H. Habe, T. Nakagawa, S. Nin, K. Ishii, Y. Lee
    16th International Workshop on Breast Imaging

  • Acceleration Motion Compensation Diffusion-weighted Imaging for Large Vessel Vasculitis: Phantom Model and Initial Clinical Experience.
    T. Hyodo, D. Morimoto-Ishikawa, H. Kaida, Y. Ueda, D. Tomita, A. Yamamoto, M. Itoh, N. Yasuda, H. Fukushima, Y. Nozaki, I. Matsumura, K. Ishii
    2022 ISMRM-ESMRMB & ISMRT

  • Quantitative Evaluation of Crohn's Disease Using Native T1 Mapping: A Feasibility Study.
    D. Morimoto-Ishikawa, T. Hyodo, Y. Komeda, H. Fukushima, Y. Ueda, K. Miyagoshi, S. Saito, K. Ishii
    2022 ISMRM-ESMRMB & ISMRT

  • Native T1 マッピングによる潰瘍性大腸炎の疾患活動性評価の初期検討.
    石川 大介, 兵頭 朋子, 米田 頼晃, 上田 優, 宮越 敬三, 齋藤 茂芳, 石井 一成
    第78回日本放射線技術学会総会学術大会

  • 腹部 CT 画像内の肝臓領域抽出.
    伊福 錬, 阿部孝司, 波部 斉, 兵頭朋子, 石井一成
    第26回電子情報通信学会関西支部学生会研究発表講演会, Mar. 2022

  • 肝細胞がん治療効果判定のためのCT画像中の早期濃染領域検出.
    福田大海, 波部斉, 阿部孝司, 兵頭朋子, 石井一成
    情報処理学会 第84回全国大会, Mar. 2022

  • 認知症診療におけるアミロイドPETの役割.
    石井一成
    第51回日本神経放射線学会, Feb. 2022
    [Invited]

  • 上下腹神経叢ブロックを用いた婦人科疾患に対するIVRの経験.
    石田奈緒子, 鶴崎正勝, 上月瞭平, 小寺 卓, 沼本勲男, 小田晃義, 石井 一成
    第70回関西INTERVENTIONAL RADIOLOGY研究会, Feb. 2022

  • 大型血管炎診断におけるMR拡散強調像の動き補正技術
    若菜みゆき, 兵頭朋子, 甲斐田勇人, 石井一成, 大介, 伊藤洵, 安田奈央, 福島弘之, 冨田大介, 山本敦弘, 野﨑祐史, 松村 到
    第330回 日本医学放射線学会関西地方会, Feb. 2022

  • 乳房専用PET装置で明瞭に描出することができた非浸潤性乳管癌症例.
    上野尚美, 花岡宏平, 渡邊翔太, 石川大介, 甲斐田勇人, 位藤俊一, 菰池佳史, 石井一成
    第31回 乳癌画像研究会, Feb. 2022

  • GANによるFDG画像からのアミロイド画像合成の可能性の検討
    山口拓起, 渡邉 綾, 山田誉大, 中前有香子, 永岡 隆, 根本充貴, 石井一成, 木村裕一
    第11回核医学画像解析研究会, Dec. 2021

  • Metastases to the extraocular muscles: MR features of institutional 16 cases and a systemic review of clinical features.
    Kashiwagi N, Miura A, Sakai M, Hyodo T, Matsuo C, Fujiwara M, Arisawa A, Ishii K, Tomiyama N
    107th Radiological Society of North America. 2021

  • Evaluation of the dedicated breast PET imaging technique including axillary region.
    K. Hanaoka, S. Watanabe, D. Morimoto-Ishikawa, T. Mizuta, A. Otani, Y. Yamakawa, H. Kaida, Y. Komoike, K. Ishii
    SNMMI 2021 Annual Meeting, English

  • Optimization of Standardized Uptake Value of Fluorodeoxyglucose for Cortical Extraction in dedicated brain PET System.
    D. Morimoto-Ishikawa, K. Hanaoka, S. Watanabe, A. Otani, T. Mizuta, Y. Yamakawa, H. Kaida, K. Ishii
    SNMMI 2021 Annual Meeting, English
    Poster presentation

  • pleural appendage（胸膜脂肪垂）の画像診断.
    松久保祐子,松木 充,若菜みゆき,鈴木絢子,浜川岳文,沼本勲男,小田晃義,門場智也,藤谷哲也,任 誠雲,兵頭朋子,甲斐田勇人,柳生行伸,小塚健倫,鶴﨑正勝,石井一成.
    第324回 日本医学放射線学会関西地方会, Feb. 2020
    Oral presentation

  • 卵巣顆粒膜細胞腫の再発・転移の画像診断.
    浜川岳文,松木 充,若菜みゆき,鈴木絢子,沼本勲男,小田晃義,門場智也,藤谷哲也,任 誠雲,松久保祐子,兵頭朋子,甲斐田勇人,柳生行伸,鶴﨑正勝,小塚健倫,石井一成, 松村謙臣, 大谷知之.
    第324回 日本医学放射線学会関西地方会, Feb. 2020
    Oral presentation

  • 認知症画像診断における統計解析の役割.
    石井一成
    第24回 ニューロイメージングカンファレンス, Feb. 2020
    Invited oral presentation

  • 知っておきたい頭部画像診断のポイント ~認知症の画像診断を中心に~
    石井一成
    第72回 なにわ臨床画像研究会, Jan. 2020
    [Invited]
    Invited oral presentation

  • TAFRO症候群の1例
    鈴木絢子, 沼本勲男, 松木 充, 小田晃義, 山田 穣, 兵頭朋子, 任 誠雲, 甲斐田勇人, 柳生行伸, 細川知紗, 小塚健倫, 柏木伸夫, 鶴﨑正勝, 今岡いずみ, 石井一成, 榎木英介, 村上卓道
    第31回日本腹部放射線学会, Jun. 2017

  • 十二指腸ブルンネル腺過誤腫の1例
    小田晃義, 松木 充, 沼本勲男, 福井秀行, 任 誠雲, 兵頭朋子, 柳生行伸, 鶴﨑正勝, 今岡いずみ, 石井一成, 村上卓道
    第31回日本腹部放射線学会, Jun. 2017

  • 認知症診断における核医学検査の現状と将来展望
    石井一成
    長崎ニューロイメージングカンファレンス, Jun. 2017

  • 認知症の画像診断〜最近の話題を含めて〜
    石井一成
    第１回日本脳神経外科認知症学会学術総会, Jun. 2017

  • 軽度認知機能患者におけるFDG-PETによるAD移行予測能の検討
    岡田佑介, 岩田香織, 加藤隆司, 木村泰之, 木澤 剛, 中村昭範, 服部英幸, 乾 好貴, 外山 宏, 石井一成, 石井賢二, 千田道雄, 伊藤健吾, 岩坪 威, J-ADNI Group
    第32回日本老年精神医学会, Jun. 2017

  • Prognostic impact of 18F-FDG PET parameters and molecular markers expression in resected non-small cell lung cancer patients
    Kaida H, Azuma K, Kwahara A, Sadashima E, Hattori S, Akiba J, Rominger A, Rakamori S, Fujimoto K, Hosono M, Ishii K, Murakami R, Ishibashi M
    SNMMI 2017 Annual Meeting, Jun. 2017

  • Integrated FDG-PET/MRI for whole-body staging in patients with recurrent gynecological cancer
    Kitajima K, Nogami M, Takahashi S, Ueno Y, Ebina Y, Kubo K, Tanaka U, Sofue K, Ishihara T, Wakabayashi Y, Ishii K, Sugimura K
    SNMMI 2017 Annual Meeting, Jun. 2017

  • 食道癌切除患者におけるFDG集積の予後検討
    甲斐田勇人, 石井一成, 細川知紗, 柳生行伸, 任 誠雲, 兵頭朋子, 山田 穣, 細野 眞, 安田卓司, 村上卓道
    第76回日本医学放射線学会総会, Apr. 2017

  • 認知症診療における核医学検査の有用性
    石井一成
    第4回富山脳機能画像カンファレンス, Mar. 2017

  • 脳脊髄液：正常圧水頭症の画像所見
    石井一成
    第36回日本画像医学会, Feb. 2017

  • 転移性耳下腺腫瘍のCT MRI所見
    柏木伸夫, 任 誠雲, 甲斐田勇人, 柳生行伸, 小塚建倫, 細川知紗, 松木 充, 鶴﨑正勝, 今岡いずみ, 細野 眞, 石井一成, 村上卓道
    第315回日本医学放射線学会関西地方会, Feb. 2017

  • 脳血流SPECT定性画像上のConvexity “APPArent” Hyperperfusion (CAPPAH) signがiNPHの診断に有用である
    大道卓摩, 近藤正樹, 徳田隆彦, 小泉英貴, 松島成典, 栗山長門, 石井一成, 森 悦郎, 山田 惠, 水野敏樹
    第18回日本正常圧水頭症学会, Feb. 2017

  • Algorithm for reference region delineation for amyloid imaging using pattern recognition scheme and kinetics of administered Aβ probe－considering the number of clusters－
    Yamada T, Kimura Y, Nagaoka T, Hosokawa C, Murakami T, Ishii K
    Human Amyloid Imaging Conference 2017, Jan. 2017

  • Noise reduction algorithm for amyloid imaging without loss of image resolution.
    Kimura Y, Fujii K, Yamada T, Hosokawa C, Sakata M, Murakami T, Ishii K
    Human Amyloid Imaging Conference 2017, Jan. 2017

  • 認知症患者における線条体アミロイド沈着の検討
    細川知紗, 石井一成, Sauerbeck J, Scheiwein F, 甲斐田勇人, 兵頭朋子, 山田 穣, 細野 眞, 花岡宏平, 村上卓道
    第56回日本核医学会学術総会, Nov. 2016

  • 非小細胞肺癌のFDG集積とGlut-1, pStat1, pStat3での予後因子の検討
    甲斐田勇人, 東 公一, 河原明彦, 服部 聡, 藤本公則, 高森信三, 藤本公則, 高森信三, 石井一成, 村上卓道, 石橋正敏
    第56回日本核医学会学術総会, Nov. 2016

  • FDG-PET/CTを契機に発見された再発性多発軟骨炎の一例
    甲斐田勇人, 石井一成, 細川知紗, 細野 眞, 村上卓道
    PETサマーセミナーin熊本, Aug. 2016

  • 日常診療における認知症画像診断
    石井一成
    第25回 宮城県核医学研究会, Jul. 2016

  • 認知症の画像診断〜読影のコツと最近の話題
    石井一成
    第35回 播淡画像研究会, Jul. 2016

  • 11C-PiB PET陽性認知症の線条体集積の有無の検討
    細川知紗, 石井一成, Julia Sauerbeck, Franziska Scheiwein, 甲斐田勇人, 兵頭朋子, 山田 穣, 細野 眞, 花岡宏平, 村上卓道
    第49回日本核医学会近畿地方会, Jul. 2016

  • Delineation algorithm on reference region for amyloid imaging using a time history of radioactivity.
    Kimura Y, Yamada T, Hosokawa C, Okada S, Nagaoka T, Ishii K
    SNMMI 2016 Annual Meeting, Jun. 2016

  • Amyloid imaging in Japan
    Ishii K
    Affiliation Bi-Annual Meeting 2016, Jun. 2016

  • Pretherapeutic FDG heterogeneity in tumors can predict local control in oropharyngeal cancer patients undergoing intensity-modulated radiation therapy
    Hanaoka K, Hosono M, Tatebe H, Ishikawa K, Monzen H, Ishii K, Nishimura Y
    SNMMI 2016 Annual Meeting, Jun. 2016

  • Cerebral glucose metabolic reduction patterns of PiB accumulation positive and negative cognitive disordered subjects
    Hosokawa C, Ishii K, Kimura Y, Kaida Y, Wakabayashi Y, Hyodo T, Hosono M, Murakami T
    SNMMI 2016 Annual Meeting, Jun. 2016

  • 十二指腸リンパ節瘻を合併した膵結核の1例
    渡口真史, 松木 充, 沼本勲男, 福井秀行, 若林雄一, 山川美帆, 任 誠雲, 兵頭朋子, 柳生行伸, 鶴崎正勝, 今岡いずみ, 石井一成, 田中利絵, 今井 元, 石川 原, 竹山宜典, 前西 修, 村上卓道
    第30回日本腹部放射線学会, Jun. 2016

  • 副腎結核の1例
    沼本勲男, 松木 充, 渡口真史, 福井秀行, 若林雄一, 山川美帆, 任 誠雲, 兵頭朋子, 柳生行伸, 鶴﨑正勝, 今岡いずみ, 石井一成, 村上卓道
    第30回日本腹部放射線学会, Jun. 2016

  • 孤立性腹部内臓動脈解離のCT所見
    福井秀行, 松木 充, 小田晃義, 沼本勲男, 日高正二朗, 任 誠雲, 兵頭朋子, 柳生行伸, 小塚健倫, 鶴﨑正勝, 今岡いずみ, 石井一成, 村上卓道
    第313回公益社団法人日本医学放射線学会関西地方会, Jun. 2016

  • Nuclear Medicine Techniques in Neurological Diseases: Alzheimer’s disease
    Ishii K
    IAEA International Workshop, May 2016

  • Increased Pittsburgh Compound B accumulation in the white matter of Alzheimer brain
    Wakabayashi Y, Ishii K, Hosokawa C, Hyodo T, Kaida H, Yamada M, Yagyu Y, Tsurusaki M, Sugimura K, Murakamai T
    日本分子イメージング学会 第11回総会・学術集会, May 2016

  • 認知症診断における機能画像(PET, SPECT)の限界と留意点
    石井一成
    第17回 アルツハイマー病研究会学術シンポジウム, Apr. 2016

  • 転移性耳下腺腫瘍のCT,MRI所見
    柏木伸夫, 日高正二朗, 福井秀行, 柳生行伸, 中西克之, 小塚健倫, 石井一成, 沼本勲男, 筑後孝章, 村上卓道
    第75回日本医学放射線学会総会, Apr. 2016

  • 認知障害の11C PiB PETでの線条体集積と脳糖代謝の相関
    細川知紗, 石井一成, 木村雄一, 甲斐田勇人, 若林雄一, 兵頭朋子, 山田 穣, 小塚健倫, 細野 眞, 村上卓道
    第75回日本医学放射線学会総会, Apr. 2016

  • 脳血流SPECTのレビューと課題
    石井一成
    第17回 日本正常圧水頭症学会, Mar. 2016

  • 神経核内封入体病の1例
    沼本勲男, 松木 充, 福井秀行, 若林雄一, 日高正二朗, 渡口真史, 藤谷哲也, 山川美帆, 兵頭朋子, 山田 穣, 任 誠雲, 甲斐田勇人, 柳生行伸, 柏木伸夫, 細川知紗, 小塚健倫, 鶴﨑正勝, 今岡いずみ, 細野 眞, 石井一成, 村上卓道
    第312回日本医学放射線学会関西地方会, Feb. 2016

  • 上顎洞術後変化としての眼窩下管拡大
    福井秀行, 柏木伸夫, 任 誠雲, 甲斐田勇人, 柳生行伸, 小塚健倫, 細川知紗, 熊野正士, 鶴﨑正勝, 松木 充, 今岡いずみ, 細野 眞, 石井一成, 村上卓道
    第35回日本画像医学会, Feb. 2016

  • 認知症の画像診断
    石井一成
    第5回 北大阪AD Meeting, Jan. 2016

  • DRLの核医学分野のトピックス
    石井一成
    第295回定例研究会, Jan. 2016

  • Bizarre parosteal osteochondromatous proliferation of the sternum
    Fukui H, Kashiwagi N, Enoki E, Nakajima Y, Numoto I, Wakabayashi Y, Toguchi M, Asato N, Yamakawa M, Im S, Hyodo T, Yagyu Y, Kumano M, Tsurusaki M, Imaoka I, Matsuki M, Ishii K, Murakami T
    第27回日本骨軟部放射線研究会, Jan. 2016

  • Low Tube Voltage CT with Iterative Reconstruction for the Diagnosis of Hepatocellular Carcinoma? HCC?
    村上 卓道, 岡田 真広, 高橋 洋人, 兵頭 朋子, 石井 一成
    99th Radiological Society of North America, Dec. 2013, 99th Radiological Society of North America, Chicago, International conference

  • Aging Effect on Cerebral Blood Flow Measurements in Brain Perfusion Imaging with 3D Arterial Spin Labeling.
    村上 卓道, 高橋 洋人, 石井 一成, 柏木 伸夫, 松木 充, 宮越 敬三
    99th Radiological Society of North America, Dec. 2013, 99th Radiological Society of North America, Chicago, International conference

  • Applications of the Fast kVp Switching Dual Energy CT for Hepatopancreato-biliary Imaging.
    兵頭 朋子, 村上 卓道, 岡田 真広, 鶴﨑 正勝, 石井 一成
    99th Radiological Society of North America, Dec. 2013, 99th Radiological Society of North America, Chicago, International conference

  • 後縦隔に発生したectopic neural tissueの1例
    村上 卓道, 朝戸 信行, 松木 充, 福井 秀行, 任 誠雲, 千葉 輝明, 高橋 洋人, 兵頭 朋子, 山田 穣, 栁生 行伸, 鶴﨑 正勝, 岡田 真広, 柏木 伸夫, 細川 知紗, 小塚 健倫, 今岡 いずみ, 足利 竜一朗, 石井 一成, 藤谷 哲也
    第305回日本医学放射線学会関西地方会, Nov. 2013, 第305回日本医学放射線学会関西地方会, 大阪, Domestic conference

  • 頭部造影MRIにおけるBlack Blood (BB) CUBE, BB CUBE-FLAIR法の有用性：1.5T・MR装置での検討
    任 誠雲, 村上 卓道, 足利 竜一朗, 柳生 行伸, 石井 一成, 日高 正二朗, 若山 哲也, 三好
    第41回日本磁気共鳴医学会大会, Sep. 2013, 第41回日本磁気共鳴医学会大会, 徳島, Domestic conference

  • ASL-MR潅流画像によるAlzheimer's disease(AD)の診断においてBorderzonesignが与える影響
    村上 卓道, 高橋 洋人, 石井 一成, 柏木 伸夫, 宮越 敬三, 足利 竜一朗, 松木 充
    徳島, Sep. 2013, 徳島, 第41回日本磁気共鳴医学会大会

  • 11C-PIB-PET SUV画像の視覚判定と定量評価
    細川 知紗, 村上 卓道, 石井 一成, 木村 裕一, 兵頭 朋子, 細野 眞, 坂口 健太, 宇佐美 公男
    第46回日本核医学会近畿地方会, Jul. 2013, 第46回日本核医学会近畿地方会, 大阪, Domestic conference

  • 後腹膜原発のlipomatous hemangiopericytomaの1例
    朝戸 信行, 村上 卓道, 鶴崎 正勝, 日高 正二朗, 松久保 祐子, 兵頭 朋子, 柳生 行伸, 岡田 真広, 今岡 いずみ, 松木 充, 足利 竜一朗, 石井 一成
    第27回日本腹部放射線研究会, Jun. 2013, 第27回日本腹部放射線研究会, 宇都宮, Domestic conference

  • 消化管病変を伴ったSchonlein-Henoch紫斑病の3例
    日高 正二朗, 村上 卓道, 松木 充, 任 誠雲, 兵頭 朋子, 山田 穣, 柳生 行伸, 鶴崎 正勝, 岡田 真広, 柏木 伸夫, 細川 知紗, 小塚 健倫, 今岡 いずみ, 足利 竜一朗, 石井 一成
    第304回日本医学放射線学会関西地方会, Jun. 2013, 第304回日本医学放射線学会関西地方会, 大阪, Domestic conference

  • F-18 FDG-PET/CT検査にて経過観察しえた原発性肝神経内分泌腫瘍の1例
    兵頭 朋子, 村上 卓道, 松木 充, 岡田 真広, 柳生 行伸, 鶴崎 正勝, 足利 竜一朗, 井上 達夫, 木村 雅友, 石井 一成
    第27回日本腹部放射線研究会, Jun. 2013, 第27回日本腹部放射線研究会, 宇都宮, Domestic conference

  • Quantitative assessment of liver fat with dual energy CT: comparison with MR spectroscopy
    兵頭 朋子, 村上 卓道, 工藤 正俊, 岡田 真広, 矢田 典久, 前西 修, 石井 一成
    Computer Assisted Radiology and Surgery, 27th Intemational Congress and Exhibition, Jun. 2013, Computer Assisted Radiology and Surgery, 27th Intemational Congress and Exhibition, ドイツ, International conference

  • 3D Artlrial spin labelingによるアルツハイマー病の脳潅琉画像：SPECTとの比較
    村上 卓道, 高橋 洋人, 石井 一成, 柏木 伸夫, 宮越 敬三, 花岡
    第72回日本医学放射線学会総会, Apr. 2013, 第72回日本医学放射線学会総会, 横浜, Domestic conference

  • Dual-energy CTによる肝脂肪定量：ファントム実験によるsingle-energy CTおよびMRSとの比較
    兵頭 朋子, 岡田 真広, 鶴崎 正勝, 足利 竜一朗, 石井 一成, 村上 卓道, 工藤 正幸
    第72回日本医学放射線学会総会, Apr. 2013, 第72回日本医学放射線学会総会, 横浜, Domestic conference

  • Phantom study of liver fat quantification in dual-energy CT: comparison to single-energy CT and MR spectroscopy.
    兵頭 朋子, 村上 卓道, 岡田 真広, 石井 一成, 工藤 正幸, 望月 輝一
    25th European Congress of Radiology, Mar. 2013, 25th European Congress of Radiology, Vienna, International conference

  • アルコール性肝障害に合併した多血性肝過形成結節の検討～画像所見を中心に～
    日高 正二朗, 村上 卓道, 鶴﨑 正勝, 兵頭 朋子, 任 誠雲, 栁生 行伸, 岡田 真広, 松木 充, 足利 竜一朗, 石井 一成
    第19回肝血流動態イメージ研究会, Jan. 2013, 第19回肝血流動態イメージ研究会, 東京, Domestic conference

  • The Usefullness of Conventional MR imaging in Establishing the Daiagnosis of Submandibular Pleomorphic Adenoma
    柏木 伸夫, 村上 卓道, 高橋 洋人, 前西 修, 石井 一成, 中西 克之
    98th Radiological Society of North America, Nov. 2012, 98th Radiological Society of North America, アメリカ, International conference

  • Distinguishing Neurodegeneratice Dementia with MRI,FDG-PET,and PiB-PET
    石井 一成, 村上 卓道, 兵頭 朋子, 高橋 洋人, 岡田 真広
    98th Radiological Society of North America, Nov. 2012, 98th Radiological Society of North America, アメリカ

  • Brain Perfusion Imaging of Alzheimer’s Disease with 3D Arterial Spin Labeling:Comparison with Brain Perfusion SPECT
    高橋 洋人, 村上 卓道, 石井 一成, 柏木 伸夫
    98th Radiological Society of North America, Nov. 2012, 98th Radiological Society of North America, アメリカ, International conference

  • 腫瘤形成した慢性顎下腺炎のFDG-PET/CT所見
    村上 卓道, 細川 知紗, 柏木 伸夫, 松久保 祐子, 山田 穣, 任 誠雲, 兵頭 朋子, 高橋 洋人, 栁生 行伸, 岡田 真広, 小塚 健倫, 今岡 いずみ, 鶴﨑 正勝, 松木 充, 足利 竜一朗, 細野 眞, 石井 一成
    第302回日本医学放射線学会関西地方会, Nov. 2012, 第302回日本医学放射線学会関西地方会, 大阪, Domestic conference

  • 認知症における脳FDG-PET早期撮像の可能性について
    兵頭 朋子, 石井 一成, 坂口 健太, 花岡 宏平, 宇佐美 公男, 島元 健次, 山添 譲, 山田 穣, 松木 充, 細野 眞, 村上 卓道
    第52回日本核医学会学術総会, Oct. 2012, 第52回日本核医学会学術総会, 札幌, Domestic conference

  • EOB-MRI肝細胞相におけるFlip angle(FA)の変化がコントラスト特性に与える影響
    西山 大輔, 村上 卓道, 岡田 真広, 香川 祐毅, 宮越 敬三, 兵頭 朋子, 高橋 洋人, 今岡 いずみ, 松木 充, 足利 竜一朗, 石井 一成, 若山 哲也
    第40回日本磁気共鳴医学会大会, Sep. 2012, 第40回日本磁気共鳴医学会大会, 京都, Domestic conference

  • レビー小体型認知症の頭頂側頭連合野の代謝低下はアミロイド沈着によらない
    石井 一成, 村上 卓道, 兵頭 朋子, 坂口 健太, 花岡 宏平, 宇佐美 公男, 島元 健次, 山添 譲, 山田 穣, 松木 充, 細野 眞
    第45回日本核医学会近畿地方会, Jul. 2012, 第45回日本核医学会近畿地方会, 京都, Domestic conference

  • 肝血行動態解析によるソラフェニブ治療効果の早期予測-CT perfusionを用いて
    兵頭 朋子, 村上 卓道, 岡田 真広, 香川 祐毅, 日高 正二朗, 任 誠雲, 栁生 行伸, 上嶋 一臣, 矢田 典久, 石井 一成, 工藤 正俊, 工藤 正幸
    第48回日本肝癌研究会, Jul. 2012, 第48回日本肝癌研究会, 石川, Domestic conference

  • Dual energy CTを用いた肝脂肪の定量評価：ファントム実験と初期臨床経験
    兵頭 朋子, 岡田 真広, 矢田 典久, 前西 修, 香川 祐毅, 任 誠雲, 柏木 伸夫, 栁生 行伸, 今岡 いずみ, 松木 充, 足利 竜一朗, 石井 一成, 工藤 正俊, 村上 卓道
    第71回近畿大学医学会学術講演会, Jul. 2012, 第71回近畿大学医学会学術講演会, 大阪, Domestic conference

  • CT perfusionによる肝血行動態解析：sorafenib投与による背景肝血流の変化と肝細胞癌治療効果
    兵頭 朋子, 村上 卓道, 岡田 真広, 香川 祐毅, 日高 正二朗, 栁生 行伸, 上嶋 一臣, 矢田 典久, 松木 充, 石井 一成, 工藤 正俊
    第12回関西肝血流動態イメージ研究会, Jun. 2012, 第12回関西肝血流動態イメージ研究会, 大阪, Domestic conference

  • Asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on MRI (AVIM)
    石井 一成, 岡田 真広, 村上 卓道
    16th Workshops of Japanese-German Radiological Affiliation, May 2012, 16th Workshops of Japanese-German Radiological Affiliation, Munster, International conference

  • Imaging for liver fibrosis in patients with chronic liver disease: comparison between T1 mapping of Gd-EOB-DTPA enhanced MRI and US elastography
    岡田 真広, 村上 卓道, 石井 一成
    16th Workshops of Japanese-German Radiological Affiliation, May 2012, 16th Workshops of Japanese-German Radiological Affiliation, Munster, International conference

  • Distinguishing Idiopathic Normal Pressure Hydrocephalus from Neurodegenerative Diseases: Diagnostic Criteria, Imaging Characteristics, and Avoidance of Pitfalls.
    石井 一成, 柏木 伸夫, 村上 卓道, 塚部明大
    RSNA ? Education Exhibits 2011, Dec. 2011, RSNA ? Education Exhibits 2011, Chicago

  • 画像を使った認知症の診断
    石井 一成, 村上 卓道
    市民公開講座：もしかして認知症？～気になりませんか、物忘れ～, Nov. 2011, 市民公開講座：もしかして認知症？～気になりませんか、物忘れ～, 大阪, Domestic conference

  • CT Perfusionによる肝細胞癌の分子標的薬治療効果予測
    兵頭 朋子, 香川 祐毅, 岡田 真広, 日高 正二朗, 柳生 行伸, 熊野 正士, 柏木 伸夫, 小塚 健倫, 今岡 いずみ, 足利 竜一朗, 石井 一成, 工藤 正俊, 北野 雅之, 上嶋 一臣, 井上 達夫, 矢田 典久, 村上 卓道, 工藤 正幸
    第2回大阪消化器画像・IVR研究会, Sep. 2011, 第2回大阪消化器画像・IVR研究会, 大阪

  • F-FDG PET/CT にてsuperscanを呈した腎癌骨転移の1例
    兵頭 朋子, 石井 一成, 植村 天受, 村上 卓道, 阪本 祐一, 中村
    第44回日本核医学会近畿地方会, Jul. 2011, 第44回日本核医学会近畿地方会, 兵庫, Domestic conference

  • CT perfusionを用いた肝細胞癌に対するソラフェニブの効果判定の検討
    村上 卓道, 香川 祐毅, 岡田 真広, 兵頭 朋子, 日高 正二朗, 柳生 行伸, 熊野 正士, 柏木 伸夫, 小塚 健倫, 今岡 いずみ, 足利 竜一朗, 石井 一成, 工藤 正俊, 北野 雅之, 上嶋 一臣, 井上 達夫, 矢田 典久, 工藤 正幸
    第11回関西肝血流動態イメージ研究会, Jul. 2011, 第11回関西肝血流動態イメージ研究会, Domestic conference

  • Correlation between biliary and liver enhancement on Gd-EOB-DTPA enhanced MR
    岡田 真広, 石井 一成, 村上 卓道
    The 2nd Asia-Pacific Primary Liver Cancer Expert Meeting, Jul. 2011, The 2nd Asia-Pacific Primary Liver Cancer Expert Meeting, 大阪, Domestic conference

  • Clinical impact of CT attenuation correction by SPECT/CT in brain perfusion images.
    石井 一成, 花岡宏平, 村上 卓道
    2011 Annual Meeting of Society of Nuclear Medicine, Jun. 2011, 2011 Annual Meeting of Society of Nuclear Medicine, San Antonio, International conference

  • Optimal parameter setting for hepatobiliary phase of Gd-EOB-DTPA enhanced liver MRI
    岡田 真広, 石井 一成, 村上 卓道
    The 3rd Asian Congress of Abdominal Radiology (ACAR),, May 2011, The 3rd Asian Congress of Abdominal Radiology (ACAR),, Beijing, International conference

  • Gd-EOB-DTPA造影MRI肝細胞相で低信号を呈する乏血性結節の多血化について
    兵頭 朋子, 岡田 真広, 香川祐毅, 熊野 正士, 今岡 いずみ, 石井 一成, 村上 卓道, 小来田 幸世, 今井, 康陽, 堀 雅敏, 望月 輝一
    日本消化器学会近畿支部第94回例会, Feb. 2011, 日本消化器学会近畿支部第94回例会, 大阪国際会議場，大阪

  • 認知症の画像診断～アミロイドイメージングによる超早期診断を含めて～
    石井 一成, 村上 卓道
    第1回南大阪の認知症診断・治療・連携を考える会, 2011, 第1回南大阪の認知症診断・治療・連携を考える会, 大阪, Domestic conference

■ Affiliated Academic Society
  • 日本磁気共鳴医学会
    - Present

  • 日本インターベンショナルラジオロジー学会（日本IVR学会）
    - Present

  • European Society of Radiology
    - Present

  • Radiological Society of North America
    - Present

  • Society of Nuclear Medicine
    - Present

  • 日本神経放射線学会
    - Present

  • 日本医学放射線学会
    - Present

  • 日本核医学会
    - Present

■ Research Themes
  • Application of gamma entrainment to patients with schizophrenia and its effect on hippocampal pathology
    柳 雅也, 橋本 衛, 石井 一成, 難波 寿明
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kindai University, 01 Apr. 2022 - 31 Mar. 2026

  • Application of gamma entrainment to patients with schizophrenia and its effect on hippocampal pathology
    柳 雅也, 橋本 衛, 石井 一成, 難波 寿明
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kindai University, 01 Apr. 2022 - 31 Mar. 2026

  • 多施設連携プラットフォーム(MABB)を基盤にした各種認知症性疾患に対する日本発の包括的な診断・層別化バイオマーカーシステムの確立
    日本医療研究開発機構(AMED), 認知症研究開発事業, Apr. 2021 - Mar. 2026

  • 血液バイオマーカーと神経画像検査によるBPSDの生物学的基盤の解明、および認知症者の層別化に基づいたBPSDケア・介入手法の開発研究
    日本医療研究開発機構(AMED), 認知症研究開発事業, Apr. 2021 - Mar. 2026, Coinvestigator

  • 食道癌術前化学療法の治療効果予測―低酸素イメージングと癌シグナル伝達因子との相関
    甲斐田 勇人, 石井 一成, 安田 卓司, 伊藤 彰彦, 細野 眞, 服部 聡, 河原 明彦
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 近畿大学, 01 Apr. 2021 - 31 Mar. 2025
    本研究の目的は、術前化学療法を受ける進行食道癌患者対象に治療開始前FMISO PET/CTで治療効果予測が可能か病理学的評価を踏まえて検討することである。さらにFMISO集積で腫瘍内低酸素やPD-L1やCD8T細胞が発現する腫瘍免疫環境を予測可能か前向き研究で検討する。 科研費交付決定後に近畿大学医学部倫理委員会に研究計画書を提出し、一括申請を行った。倫理委員会で研究実施実施計画が承認された後に食道癌の病理組織標本に免疫染色行うための抗体やFMISOの薬剤合成にかかる消耗品の購入、FMISO PET/CTの検査が円滑に進められるように研究体制を整えた。倫理委員会承認後本研究を開始し、共同研究を行う上部消化管外科と密接に連携して、研究に参加可能な対象者を集め始めた。初年度は研究体制整備が主だった実績となった。 今年度は10症例程度を目標に予定していたが、医学部倫理委員会に申請する研究計画書の作成やその審査にかなり時間を要し、計画に遅れが生じた。次年度からは研究に該当する食道癌患者の収集を第一に努め、収集症例数をあげることである。また、食道癌の術前化学療法後、手術を行った患者の病理染色標本の染色および患者の経過観察に関して円滑に進めていけるように関係各所（近畿大学上部消化管外科、近畿大学病理学講座、久留米大学病院病理部病理診断科、大阪大学大学院医学系研究科情報統合医学講座医学統計学）との連携を再確認して、随時研究の打ち合わせの実施を行う。

  • ディープラーニングを用いたマンモグラム時系列解析による対側乳癌予測システムの開発
    山室 美佳, 李 鎔範, 浅井 義行, 石井 一成
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 近畿大学, 01 Apr. 2021 - 31 Mar. 2024
    乳腺密度を軸とする対側乳癌発症リスク予測システム確立の基礎実験として、先行研究で収集済みの3000症例の生データマンモグラムについて人工知能技術を用い、乳腺密度算出のための乳腺領域を抽出するU-netモデルを作成した. 今後、過去に遡っての画像や、他院で撮影された画像を研究に利用できるようにするため、当院の標準画像処理条件で作成した乳腺領域抽出のためのU-netモデルが、異なる画像処理を行ったマンモグラムに適用できるかどうかを評価した. 4つの異なる処理を施した画像に作成したU-netを適応して抽出された領域の乳腺密度とGround Truthを比較し、Bland-Altman解析を行った. その結果、ダイナミックレンジ圧縮を強くするとU-netモデルへの影響が顕著となり、固定誤差や比例誤差を生じる要因となるため注意が必要ではあるが、日常診療で使用される範囲内での画像処理の違いはU-netモデルの適用精度に顕著な影響を及ぼすことはなく、少なくともGround Truthとの互換性が保たれていると判断できた. 次にRaw dataを用いず、臨床画像に付帯している情報のみで乳腺密度を推定するための予備実験を行なった. 簡易的に画素値のみで乳腺を含むと判断した領域の乳腺密度値2223例について、重回帰式を作成すると乳腺密度の全変動の90%程度を説明できることがわかった. これらの研究と同時に2000例程度の生データマンモグラムを追加収集した. そのうち1700例程度が対側乳癌症例であり、更にこの内７割が連続してデータ収集できている症例であった.

  • 血液バイオマーカーによる認知症の統合的層別化システムの開発
    日本医療研究開発機構(AMED), 次世代治療・診断実現のための創薬基盤技術開発事業, Apr. 2019 - Mar. 2024, Coinvestigator

  • To elucidate the prognostic marker using amino acid PET imaging and signal transduction factors in brain tumor patients
    KAIDA HAYATO
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kindai University, 01 Apr. 2016 - 31 Mar. 2021
    The aim of this study is to reveal the correlation and prognostic factors among 11C-methionine (MET) uptake and signal transduction factors and to investigate the pathological relationship between amino acid metabolism and tumor cell proliferation in glioma patients undergoing both PET/CT and operation. Our data showed that MET uptake in glioma had positive correlation with L-type amino acid transporter-1 (LAT-1) and that MET uptake in glioma have potential role in predicting both the degree of malignancy and epidermal growth factor receptor (EGFR). Our data also suggest that LAT-1 expression may be related with tumor hypoxia.

  • 適時適切な医療・ケアを目指した、認知症の人等の全国的な情報登録・追跡を行う研究
    日本医療研究開発機構（AMED), 長寿・障害総合研究事業, Apr. 2016 - Mar. 2020, Coinvestigator

  • ISHII Kazunari, MURAKAMI Takamichi, OKADA Masahiro, KUMANO Seishi
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kinki University, 2011 - 2013
    The purpose of this study was to clarify whether regional hypometabolism is related to amyloid deposits in the dementia with Lewy bodies (DLB) brain. Methods: Ten consecutive subjects with DLB and 10 Alzheimer disease (AD) patients who underwent both PiB-PET and FDG-PET were included in this study. Regional standardized uptake value ratio (SUVR)s normalised to cerebellar cortices were calculated in the FDG and PiB PET images.Results: All AD patients and five DLB patients showed amyloid deposits (PiB positive). The parietotemporal and occipital metabolism in the DLB group were significantly lower than those in the AD group. In DLB patients, there were no differences in regional glucose metabolism between PiB positive and negative patients. Conclusions: In the DLB brain, decreased regional glucose metabolism is unrelated to amyloid deposits, although the hypometabolic area overlaps with the AD hypometabolic area.

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