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UESHIMA Eisuke
University Hospital / Center for Radiology and Radiation Oncology
Associate Professor

Researcher basic information

■ Research Areas
  • Life sciences / Radiology / Interventional Radiology
■ Committee History
  • May 2024 - Present, 日本IVR学会, 他学会ガイドライン委員会
  • May 2018 - May 2021, 日本IVR学会, 編集委員会
  • May 2018 - May 2021, 日本IVR学会, ガイドライン委員会

Research activity information

■ Award
  • Apr. 2026 日本医学放射線学会, 板井研究奨励賞, 腹部画像診断から拓く免疫治療時代の肝細胞癌個別化医療

  • Mar. 2024 JVIR Editor’s Award for Distinguished Laboratory Investigation

  • May 2023 日本IVR学会, 優秀論文賞（掲載論文）, 【Intermediate stage HCCに対するTACE】TACEにおける腫瘍微小環境の変化と分子標的薬・免疫治療併用の意義

  • Apr. 2021 日本医学放射線学会, 栗林研究奨励賞, Hepatic Artery Embolization Induces the Local Overexpression of Transforming Growth Factor β1 in a Rat Hepatoma Model.
    上嶋 英介

  • Jun. 2019 兵庫県健康財団, 兵庫県健康財団 令和元年度がん研究奨励賞, 肝癌局所療法後に生じる免疫抑制性サイトカインの産生メカニズムの解明および阻害法の探索
    上嶋 英介

  • Apr. 2019 日本医学放射線学会, 2018年度Bayer研究助成受賞, 肝細胞癌に対するレンバチニブとTACE併用療法：ラット肝癌モデルを用いた検討
    上嶋 英介

  • Apr. 2019 Japanese Society of Radiology, 2018 JJR excellent paper, Classification of uterine artery angiographic images: a predictive factor of failure in uterine artery embolization for postpartum hemorrhage
    Eisuke UESHIMA

  • Mar. 2015 Society of Interventional Radiology(SIR), 2014 JVIR Editor’s Award for Outstanding Laboratory Investigation, Inhibition of Growth in a Rabbit VX2 Thigh Tumor Model with Intraarterial Infusion of Carbon Dioxide (CO2)-saturated Solution
    Ueshima Eisuke
    International society

■ Paper
  • Shohei Komatsu, Toshifumi Tada, Nobuaki Ishihara, Masaki Omori, Takanori Matsuura, Eisuke Ueshima, Keitaro Sofue, Yoshimi Fujishima, Jun Ishida, Masahiro Kido, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Yoshihide Nanno, Hiroaki Yanagimoto, Yuzo Kodama, Takumi Fukumoto
    BACKGROUND: The classification of oncological resectability for hepatocellular carcinoma (HCC) has been established, requiring validation of treatment outcomes for hepatectomy and systemic chemotherapy. METHODS: The study evaluated treatment outcomes in 978 patients who underwent hepatectomy and 222 patients with HCC who received first-line systemic chemotherapy (atezolizumab plus bevacizumab, lenvatinib, or durvalumab plus tremelimumab). RESULTS: Among three factors defining patients with borderline resectable 1 (BR1) and 2 (BR2), macrovascular invasion factor was associated with significantly worse prognosis in a hepatectomy group (BR1: 34.2 vs. 63.4 months, p = 0.04; BR2: 14.4 vs. 20.9 months, p = 0.004). In contrast, in the systemic chemotherapy group, none of the three factors affected prognosis in either BR1 or BR2 patients. In BR2 patients undergoing hepatectomy, those with a single risk factor had significantly better outcomes than those with 2-3 factors (20.1 vs. 12.6 months, p < 0.001). Similarly, in the entire systemic chemotherapy cohort, patients with a single risk factor had better outcomes than those with 2-3 (22.6 vs. 11.9 months, p = 0.001). However, among chemotherapy responders (per modified Response Evaluation Criteria in Solid Tumors), prognosis did not significantly differ between those with one factor and those with 2-3 factors (25.4 vs. 24.5 months, p = 0.502). CONCLUSION: Macrovascular invasion significantly impacted prognosis in patients undergoing hepatectomy, for both BR1 and BR2, whereas any of the tumor factors did not affect the prognosis of patients receiving systemic chemotherapy. Tumor burden correlated with prognosis in the entire cohort but not in chemotherapy responders, suggesting effective treatment may overcome poor prognostic indicators.
    Apr. 2026, World journal of surgery, 50(4) (4), 1049 - 1058, English, International magazine
    Scientific journal

  • Keitaro Sofue, Kentaro Nishiuchi, Kazuki Ishikawa, Yoshiko Ueno, Noriyuki Negi, Akihiro Umeno, Ryohei Kozuki, Takeru Yamaguchi, Eisuke Ueshima, Takahiro Tsuboyama, Izumi Imaoka, Takamichi Murakami
    This study aimed to compare image quality between photon-counting detector computed tomography (PCD-CT) and third-generation dual-source energy-integrating detector CT (EID-CT) in multiphasic contrast-enhanced abdominal imaging using intraindividual analysis. This retrospective study included 88 patients who underwent both arterial phase (AP) and portal venous phase (PVP) abdominal CT with PCD-CT and EID-CT. Virtual monoenergetic images (VMIs) from 50 to 90 keV were reconstructed in PCD-CT, and 120 kVp images were applied in EID-CT. Quantitative image analysis evaluated CT attenuation, image noise, and contrast-to-noise ratio (CNR) in abdominal organs and vessels. Qualitative image quality, including vessel and parenchymal contrast, noise, and overall image quality, was assessed by two radiologists using a 5-point Likert scale. Compared with EID-CT, VMIs at 50–70 keV obtained from PCD-CT demonstrated significantly higher CT attenuation values (P < 0.001) across all evaluated abdominal organs and vessels. CNRs at 70 keV were significantly greater than those in EID-CT for all objects (P < 0.001), with increases of 13.3‒41.6% on AP and 40.4‒49.3% on PVP. Image noise in 70 keV VMI was lower than EID-CT (P < 0.001). Optimal image quality was achieved using VMIs at 60–70 keV, which achieved significantly higher qualitative scores (P < 0.001) than those from EID-CT. Substantial interobserver agreement was observed (κ = 0.60–0.79). The CT dose volume index was slightly lower with PCD-CT compared with EID-CT (P < 0.001), whereas dose-length product values remained similar. PCD-CT significantly improved image quality in multiphasic abdominal CT compared with third-generation dual-source EID-CT under equivalent radiation dose conditions. The superior iodine enhancement and higher CNR in VMIs at 60–70 keV highlight the advantages of PCD-CT.
    Mar. 2026, Scientific reports, 16(1) (1), English, International magazine
    Scientific journal

  • Akihiro Umeno, Mizuho Nishio, Hidetoshi Matsuo, Takaaki Matsunaga, Munenobu Nogami, Eisuke Ueshima, Keitaro Sofue, Takamichi Murakami
    OBJECTIVE: This study aims to evaluate whether large language models (LLMs) can accurately predict the urgency and severity of radiology reports. MATERIALS AND METHODS: Based on the recommendations of the Academy of Royal Colleges, we defined radiology reports that include unexpected findings of high urgency or severity as "high-priority (HP) radiology reports." Overall, 1906 radiology reports were used as the training set, and 176 radiology reports were used as the test set, with a balanced ratio of HP to non-HP radiology reports (1:1) in both sets. Four types of LLMs (Llama2 7B, Llama3 8B, Llama3 Elyza 8B, and Llama 3.1 8B) were fine-tuned using four different input settings: (1) findings only, (2) findings + referring department, (3) findings + referring department + clinical diagnosis before examination, and (4) findings + referring department + clinical diagnosis before examination + details of examination request. The fine-tuned LLMs predicted whether each radiology report was HP or not. RESULTS: Among the four LLMs, Llama3 Elyza 8B, with inputs comprising findings and the referring department, demonstrated the best performance, achieving PRAUC = 0.962, ROCAUC = 0.968, accuracy = 0.915, sensitivity/recall = 0.932, specificity = 0.898, and F1 = 0.916. Adding a clinical diagnosis before the examination and details of examination requests did not necessarily lead to performance improvement. CONCLUSION: The fine-tuned LLMs accurately predicted HP radiology reports, suggesting their potential utility in supporting communication regarding radiology reports with high urgency or severity. KEY POINTS: Question This study aims to evaluate whether large language models (LLMs) can accurately predict the high-priority (HP) radiology reports. Findings The fine-tuned best LLM accurately HP radiology reports, achieving PRAUC of 0.962 and ROCAUC of 0.968. Clinical relevance This study demonstrates that fine-tuned LLMs can accurately identify HP radiology reports, potentially improving timely clinical decision-making and enhancing patient safety through faster communication of critical findings.
    Dec. 2025, European radiology, English, International magazine
    Scientific journal

  • Masaki Omori, Shohei Komatsu, Toshifumi Tada, Nobuaki Ishihara, Takanori Matsuura, Eisuke Ueshima, Yoshimi Fujishima, Jun Ishihda, Masahiro Kido, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Hiroaki Yanagimoto, Keitaro Sofue, Yuzo Kodama, Takumi Fukumoto
    BACKGROUND: This study evaluated how lesion location affects treatment response and prognosis in hepatocellular carcinoma (HCC) patients treated with lenvatinib (LEN) or immune checkpoint inhibitors (ICIs; atezolizumab/bevacizumab or durvalumab/tremelimumab). Considering tumor microenvironment and heterogeneity, we analyzed lesion-specific responses to optimize therapy. METHODS: In this retrospective study, lesion-specific responses were assessed for intrahepatic lesions (IHLs), lung, lymph node, intra-abdominal, and other lesions; bone metastases were excluded due to evaluation limitations. Responses were measured using a modified size-based RECIST 1.1 method. Lesion-specific objective response rate (ORR) and disease control rate (DCR) were compared between LEN and ICI groups. RESULTS: ORR for IHLs was higher with ICIs than LEN (16.3 % vs. 3.5 %, P = 0.002). No significant differences were observed for lung, lymph node, or intra-abdominal lesions; adrenal metastases showed no response in either group. Subgroup analysis indicated better ORR and DCR for lung lesions treated with ICIs and lymph node lesions treated with LEN in patients without IHLs versus those with IHLs. CONCLUSIONS: ICIs achieved higher ORR in IHLs than LEN, with no significant differences for metastatic lesions. The presence of IHLs may influence distant lesion response, and therapeutic efficacy varies with treatment regimen.
    Nov. 2025, HPB : the official journal of the International Hepato Pancreato Biliary Association, English, International magazine
    Scientific journal

  • Nobuaki Ishihara, Shohei Komatsu, Toshifumi Tada, Takanori Matsuura, Eisuke Ueshima, Keitaro Sofue, Masaki Omori, Masahiro Kido, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Kentaro Tai, Toshihiko Yoshida, Keisuke Arai, Hiroaki Yanagimoto, Yuzo Kodama, Takamichi Murakami, Takumi Fukumoto
    INTRODUCTION: Recurrent hepatocellular carcinoma (HCC) after hepatectomy remains a major clinical challenge, necessitating effective prognostic stratification. The oncological resectability criteria recently proposed by the Japan Liver Cancer Association and the Japanese Society of Hepato-Biliary-Pancreatic Surgery have not yet been validated in recurrent settings. This study aimed to evaluate the prognostic utility of these criteria in patients with recurrent HCC after hepatectomy. METHODS: This retrospective study included 505 patients with recurrent HCC following initial hepatectomy. Patients were classified into three groups-resectable (R), borderline resectable 1 (BR1), and borderline resectable 2 (BR2)-based on the oncological resectability criteria. Post-recurrence survival was evaluated using the Kaplan-Meier method, and multivariate analysis was performed to identify clinical factors associated with post-recurrence survival. RESULTS: Among the 505 patients, 248 patients were classified as R, 80 as BR1, and 177 as BR2. The median post-recurrence survival was 73.4 months for the R group, 33.6 months for the BR1 group, and 12.4 months for the BR2 group (p < 0.001). Multivariate analysis identified BR1/BR2 classification (p < 0.001), modified albumin-bilirubin grade 2b or 3 (p < 0.001), and recurrence within 1 year (p = 0.004) as independent predictors of poor post-recurrence survival. CONCLUSIONS: The oncological resectability criteria effectively stratified post-recurrence survival in patients with recurrent HCC. These findings suggest that a multidisciplinary approach may benefit patients with BR1 or BR2 recurrence. Further studies are warranted to explore optimal treatment strategies for recurrent HCC.
    Nov. 2025, Hepatology research : the official journal of the Japan Society of Hepatology, English, International magazine
    Scientific journal

  • Shohei Komatsu, Toshifumi Tada, Kazuki Terashima, Nobuaki Ishihara, Masaki Omori, Takanori Matsuura, Eisuke Ueshima, Keitaro Sofue, Yuzo Kodama, Takumi Fukumoto
    BACKGROUND: The introduction of atezolizumab plus bevacizumab (Ate/Bev) has improved hepatocellular carcinoma (HCC) treatment, enabling the concept of "ABC conversion," where curative treatments follow Ate/Bev. However, the optimal post-Ate/Bev treatment strategy remains unclear. METHODS: This study evaluated 149 patients with unresectable HCC treated with Ate/Bev and categorized them into six groups: drug-free, surgery, radiotherapy, transcatheter arterial chemoembolization/hepatic arterial infusion chemotherapy (TACE/HAIC), chemotherapy, and best supportive care (BSC). The surgery, radiotherapy, and TACE/HAIC groups were classified as "local conversion" and further subdivided into two subtypes based on the therapeutic intent: "curative local conversion" and "palliative local conversion." RESULTS: The 3-year overall survival (OS) rates for patients in the drug-free, surgery, radiotherapy, TACE/HAIC, chemotherapy, and BSC groups were 100.0%, 66.7%, 52.6%, 41.0%, 13.6%, and 10.1%, respectively (p < 0.001). No significant differences were observed between the surgery and TACE/HAIC groups (3-year OS: 66.7% vs. 41.0% and p = 0.441) or between the radiotherapy and TACE/HAIC groups (3-year OS: 52.6% vs. 41.0% and p = 0.838). Patients who underwent local conversion had a significantly better median survival time (28.0 vs. 16.3 months and p < 0.001). The 3-year OS rates for patients who underwent curative and palliative local conversion were 68.6% and 37.0%, respectively. Although curative local conversion demonstrated better prognosis than that noted with palliative local conversion, the difference was not statistically significant (p = 0.155). CONCLUSION: Local conversion after Ate/Bev treatment may potentially improve survival rates. Even when curative local conversion is not feasible, palliative local conversion may still offer clinical benefits.
    Oct. 2025, World journal of surgery, 49(10) (10), 2854 - 2862, English, International magazine
    Scientific journal

  • Noriko Juri, Atsuhiro Masuda, Ryota Nakano, Takao Kato, Yuichi Hirata, Koichi Fujita, Shigeto Ashina, Megumi Takagi, Hirofumi Ogawa, Takashi Nakagawa, Seiji Fujigaki, Kyohei Ogisu, Takao Iemoto, Takeshi Ezaki, Yosuke Yagi, Kodai Yamanaka, Takuya Ikegawa, Yu Sato, Keisuke Furumatsu, Masahiro Tsujimae, Arata Sakai, Takashi Kobayashi, Hideyuki Shiomi, Tsuyoshi Sanuki, Yoshifumi Arisaka, Yoshihiro Okabe, Eisuke Ueshima, Keitaro Sofue, Norimitsu Uza, Yuzo Kodama
    BACKGROUND & AIMS: Autoimmune pancreatitis (AIP) could induce peripancreatic vascular involvement, such as portal system stenosis, through inflammatory extension, resulting in the development of collateral vessels. In severe cases, gastric varices may develop, leading to a life-threatening risk of variceal rupture. However, these complications remain underrecognized and are not explicitly addressed in the current clinical guidelines. This study aimed to evaluate the frequency of vascular involvement in AIP, assess therapeutic effects of glucocorticoids, and identify key vessels associated with gastric varices. METHODS: This multicenter retrospective study included 230 patients diagnosed with AIP at 17 institutions in Japan between 2010 and 2021. We analyzed clinical data, contrast-enhanced computed tomography images, and endoscopy findings. All images were evaluated individually by 3 professionals at a central facility. The primary outcome was the frequency of peripancreatic vascular involvement. RESULTS: At diagnosis, 51.3% of the patients exhibited peripancreatic vascular involvement, primarily in the splenic vein (48.3%), superior mesenteric vein (23.9%), and portal vein (9.6%). Collateral vessel formation was observed in 40.0% of patients, with 24.3% being severe; 2 gastric variceal ruptures occurred prior to therapy. Glucocorticoid therapy significantly improved venous stenosis (response rates: 95.6%, 93.8%, and 93.1% in the splenic, portal, and superior mesenteric veins, respectively). Additionally, 80.9% of patients exhibited collateral vessel improvement. Among 55 patients who underwent upper endoscopy, 10.9% had gastric varices strongly associated with severe splenic vein stenosis. CONCLUSIONS: Peripancreatic vascular involvement represents a common complication of AIP and significantly responds to glucocorticoid therapy, underscoring the importance of careful monitoring to prevent potentially fatal outcomes.
    Aug. 2025, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Keigo Matsushiro, Takuya Okada, Koji Sasaki, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Katsuhiro Yamanaka, Masatoshi Hori, Masato Yamaguchi, Koji Sugimoto, Kenji Okada, Takamichi Murakami
    PURPOSE: We conducted a prospective study to evaluate the usefulness of ultralow-dose computed tomography (ULD-CT) with deep-learning reconstruction (DLR) compared with conventional standard-dose CT (SD-CT) for post-endovascular aneurysm repair (EVAR) surveillance. MATERIALS AND METHODS: We prospectively performed post-EVAR surveillance using ULD-CT at a single center in 44 patients after they had received SD-CT. The ULD-CT images underwent DLR, whereas the SD-CT images underwent iterative reconstruction. Three radiologists blinded to the patient information and CT conditions independently measured the aneurysmal sac diameter and evaluated the overall image quality. Bland-Altman analysis and a linear mixed-effects model were used to assess and compare the measurement accuracy between SD-CT and ULD-CT. RESULTS: The mean CT dose index volume and dose-length product were significantly lower for ULD-CT (1.0 ± 0.3 mGy and 71.4 ± 26.5 mGy•cm) than that for SD-CT (6.9 ± 0.9 mGy and 500.9 ± 96.0 mGy•cm; p<0.001). The mean short diameters of the aneurysmal sac measured by the 3 observers were 46.7 ± 10.8 mm on SD-CT and 46.3 ± 10.8 mm on ULD-CT. The mean difference in the short diameter of the aneurysmal sac between ULD-CT and SD-CT was -0.37 mm (95% confidence interval, -0.6 to -0.12 mm). The intraobserver limits of agreement (LOA) for measurements by ULD-CT and SD-CT were -3.5 to 2.6, -2.8 to 1.9, and -2.9 to 2.3 for Observers 1, 2, and 3, respectively. The pairwise LOAs for assessing interobserver agreement, such as for the differences between Observers 1 and 2 measurements in SD-CT, were mostly within the predetermined acceptable range. The mean image-quality score was lower for ULD-CT (3.3 ± 0.6) than that for SD-CT (4.5 ± 0.5; p<0.001). CONCLUSION: Aneurysmal sac diameter measurements by ULD-CT with DLR were sufficiently accurate for post-EVAR surveillance, with substantial radiation reduction versus SD-CT.Clinical ImpactDeep-learning reconstruction (DLR) is implemented as a software-based algorithm rather than requiring dedicated hardware. As such, it is expected to be integrated into standard computed tomography (CT) systems in the near future. The ultralow-dose CT (ULD-CT) with DLR evaluated in this study has the potential to become widely accessible across various institutions. This advancement could substantially reduce radiation exposure in post-endovascular aneurysm repair (EVAR) CT imaging, thereby facilitating its adoption as a standard modality for post-EVAR surveillance.
    Jun. 2025, Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 15266028251339345 - 15266028251339345, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Keitaro Sofue, Yoshiko Ueno, Shinji Yabe, Eisuke Ueshima, Takeru Yamaguchi, Atsuhiro Masuda, Arata Sakai, Hirochika Toyama, Takumi Fukumoto, Masatoshi Hori, Takamichi Murakami
    PURPOSE: This study aimed to evaluate the image quality and clinical utility of a deep learning reconstruction (DLR) algorithm in ultra-high-resolution computed tomography (UHR-CT) for the diagnosis of pancreatic cystic neoplasms (PCNs). METHODS: This retrospective study included 45 patients with PCNs between March 2020 and February 2022. Contrast-enhanced UHR-CT images were obtained and reconstructed using DLR and hybrid iterative reconstruction (IR). Image noise and contrast-to-noise ratio (CNR) were measured. Two radiologists assessed the diagnostic performance of the imaging findings associated with PCNs using a 5-point Likert scale. The diagnostic performance metrics, including sensitivity, specificity, and area under the receiver operating characteristic curve (AUROC), were calculated. Quantitative and qualitative features were compared between CT with DLR and hybrid IR. Interobserver agreement for qualitative assessments was also analyzed. RESULTS: DLR significantly reduced image noise and increased CNR compared to hybrid IR for all objects (p < 0.001). Radiologists rated DLR images as superior in overall quality, lesion delineation, and vessel conspicuity (p < 0.001). DLR produced higher AUROC values for diagnostic imaging findings (ductal communication: 0.887‒0.938 vs. 0.816‒0.827 and enhanced mural nodule: 0.843‒0.916 vs. 0.785‒0.801), although DLR did not directly improve sensitivity, specificity, and accuracy. Interobserver agreement for qualitative assessments was higher in CT with DLR (κ = 0.69‒0.82 vs. 0.57‒0.73). CONCLUSION: DLR improved image quality and diagnostic performance by effectively reducing image noise and improving lesion conspicuity in the diagnosis of PCNs on UHR-CT. The DLR demonstrated greater diagnostic confidence for the assessment of imaging findings associated with PCNs.
    May 2025, Japanese journal of radiology, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Keitaro Sofue, Eisuke Ueshima, Yoshiko Ueno, Takeru Yamaguchi, Masatoshi Hori, Takamichi Murakami
    This study aimed to evaluate the image quality of virtual monochromatic images (VMIs) reconstructed with deep learning image reconstruction (DLIR) using dual-energy CT (DECT) to diagnose pancreatic ductal adenocarcinoma (PDAC). Fifty patients with histologically confirmed PDAC who underwent multiphasic contrast-enhanced DECT between 2019 and 2022 were retrospectively analyzed. VMIs at 40-100 keV were reconstructed using hybrid iterative reconstruction (ASiR-V 30% and ASiR-V 50%) and DLIR (TFI-M) algorithms. Quantitative analyses included contrast-to-noise ratios (CNR) of the major abdominal vessels, liver, pancreas, and the PDAC. Qualitative image quality assessments included image noise, soft-tissue sharpness, vessel contrast, and PDAC conspicuity. Noise power spectrum (NPS) analysis was performed to examine the variance and spatial frequency characteristics of image noise using a phantom. TFI-M significantly improved image quality compared to ASiR-V 30% and ASiR-V 50%, especially at lower keV levels. VMIs with TFI-M showed reduced image noise and higher pancreas-to-tumor CNR at 40 keV. Qualitative evaluations confirmed DLIR's superiority in noise reduction, tissue sharpness, and vessel conspicuity, with substantial interobserver agreement (κ = 0.61-0.78). NPS analysis demonstrated effective noise reduction across spatial frequencies. DLIR significantly improved the image quality of VMIs on DECT by reducing image noise and increasing CNR, particularly at lower keV levels. These improvements may improve PDAC detection and assessment, making it a valuable tool for pancreatic cancer imaging.
    Apr. 2025, Journal of imaging informatics in medicine, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hironori Yawata, Eisuke Ueshima, Tomoyuki Gentsu, Yojiro Koda, Shunsuke Miyahara, Keigo Matsushiro, Koji Sasaki, Takuya Okada, Keitaro Sofue, Masato Yamaguchi, Koji Sugimoto, Takamichi Murakami
    Although transcatheter arterial embolization is the first choice treatment for renal arteriovenous malformation. Renal arteriovenous malformation with dilated venous sac can cause venous pulmonary thromboembolism after transcatheter arterial embolization. A woman in her 60s was diagnosed with a left renal arteriovenous malformation and an 8 cm venous sac with renal dysfunction after right renal arteriovenous malformation treatment. We performed a hybrid treatment of transcatheter arterial embolization and sequential vein ligation to reduce the risk of lethal thrombotic complications. After treatment, the left renal arteriovenous malformation disappeared without fatal complications, and the venous sac shrunk with the preservation of renal function as it was before the hybrid treatment. When performing embolization of renal arteriovenous malformation with a huge venous sac, hybrid treatment of arterial embolization and surgical vein ligation may be safe and useful for preventing fatal post-operative thrombotic complications.
    Mar. 2025, Interventional radiology (Higashimatsuyama-shi (Japan), 10, e20240005, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Keigo Matsushiro, Tomoyuki Gentsu, Masato Yamaguchi, Koji Sasaki, Eisuke Ueshima, Takuya Okada, Ryota Kawasaki, Koji Sugimoto, Takamichi Murakami
    The Japanese Society of Interventional Radiology, Mar. 2025, Interventional Radiology, 10, e2023 - 0048
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Koji Sasaki, Takuya Okada, Masato Yamaguchi, Masashi Ozaki, Yutaro Okamoto, Akihiro Umeno, Tomoharu Yamanaka, Keigo Matsushiro, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Takamichi Murakami
    The Japanese Society of Interventional Radiology, Mar. 2025, Interventional Radiology, 10, e2024 - 0018
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Eisuke Ueshima, Keitaro Sofue, Shohei Komatsu, Nobuaki Ishihara, Masato Komatsu, Akihiro Umeno, Kentaro Nishiuchi, Ryohei Kozuki, Takeru Yamaguchi, Takanori Matsuura, Toshifumi Tada, Takamichi Murakami
    Background/Objectives: Although immunotherapy is the primary treatment option for intermediate-stage hepatocellular carcinoma (HCC), its efficacy varies. This study aimed to identify non-invasive imaging biomarkers predictive of the immunoscore linked to dynamic contrast-enhanced computed tomography (CECT). Methods: We performed immunohistochemical staining with CD3+ and CD8+ antibodies and counted the positive cells in the invasive margin (IM) and central tumor (CT), converting them to an immunoscore of 0 to 4 points. We assessed the dynamic CECT findings obtained from 96 patients who underwent hepatectomy for HCC and evaluated the relationship between dynamic CECT findings and immunoscores. For validation, we assessed the treatment effects on 81 nodules using the Response Evaluation Criteria in Solid Tumors in another cohort of 41 patients who received combined immunotherapy with atezolizumab and bevacizumab (n = 27) and durvalumab and tremelizumab (n = 14). Results: HCCs with peritumoral enhancement in the arterial phase (p < 0.001) and rim APHE (p = 0.009) were associated with the immunoscore in univariate linear regression analysis and peritumoral enhancement in the arterial phase (p = 0.004) in multivariate linear regression analysis. The time to nodular progression in HCCs with peritumoral enhancement in the arterial phase was significantly longer than that in HCCs without this feature (p < 0.001). Conclusions: We identified HCCs with peritumoral enhancement in the arterial phase as a noninvasive imaging biomarker to predict immune-inflamed HCC with a high immunoscore tendency. These HCCs were most likely to respond to combined immunotherapy.
    Lead, Mar. 2025, Cancers, 17(6) (6), English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • UAE後に発見されたIntravenous leiomyomatosisの1例
    細見 竜太郎, 岡田 卓也, 浦瀬 靖代, 松代 啓吾, 佐々木 康二, 元津 倫幸, 上嶋 英介, 上野 嘉子, 山口 雅人, 村上 卓道, 西本 昌司, 長又 哲史, 寺井 義人, 今岡 いずみ, 前田 隆樹
    (公社)日本医学放射線学会, Feb. 2025, Japanese Journal of Radiology, 43(Suppl.) (Suppl.), 27 - 27, Japanese

  • Tomoyuki Gentsu, Masato Yamaguchi, Koji Sasaki, Keigo Matsushiro, Eisuke Ueshima, Takuya Okada, Koji Sugimoto, Takamichi Murakami
    Preemptive side branch embolization may help prevent type II endoleak, reduce reintervention rates, and promote early aneurysm sac shrinkage after endovascular aneurysm repair. However, evidence of its effectiveness in preventing aneurysm rupture, reducing aneurysm-related mortality, ensuring safety, and maintaining cost-effectiveness is limited. The 2024 European Society for Vascular Surgery guidelines do not recommend routine preemptive embolization due to a lack of high-quality evidence. Concerns about radiation exposure and financial costs remain unresolved. Further research is needed to identify patients who would benefit most from preemptive embolization, as well as to evaluate its long-term impact on clinical outcomes, safety, and cost-effectiveness.
    2025, Interventional radiology (Higashimatsuyama-shi (Japan), 10, e20240037, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Koji Sasaki, Masato Yamaguchi, Akihiro Umeno, Tomoharu Yamanaka, Keigo Matsushiro, Tomoyuki Gentsu, Eisuke Ueshima, Takamichi Murakami
    This case report presents a unique endovascular technique using an electrically detachable coil as a temporary anchor for the treatment of a saccular celiac artery aneurysm. A man in his 60s with a 28-mm saccular aneurysm in the main trunk of the celiac artery underwent coil embolization. The short distance between the aneurysm and the bifurcation of the common hepatic and splenic arteries posed a significant challenge in preserving the bifurcation. By employing a detachable coil as a temporary anchor, the procedure enabled precise coil placement and eliminated the need for stents or balloons. Five-year outpatient follow-up imaging confirmed bifurcation patency and no aneurysm recurrence. This temporary anchoring technique can provide a practical alternative for embolization without the need for additional stents or balloons.
    2025, Interventional radiology (Higashimatsuyama-shi (Japan), 10, e20240061, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Shinsaku Yata, Miyuki Sone, Kazumasa Seiji, Yuichiro Izumi, Yu Murakami, Hiroki Higashihara, Eisuke Ueshima, Munehiro Sugiyama, Tomohiro Komada, Satoru Morita, Hitomi Kato, Ryohei Kuwatsuru, Akira Adachi, Tomohiro Matsumoto, Takuji Yamagami
    Uterine artery embolization is a treatment option for symptomatic uterine myomas. The Japanese Society of Interventional Radiology Guideline Committee developed guidelines for uterine artery embolization procedures for symptomatic uterine myomas using an evidence-based methodology. This report describes the rationale for developing these guidelines and provides answers to clinical questions concerning uterine artery embolization procedures based on existing evidence and expert consensus.
    2025, Interventional radiology (Higashimatsuyama-shi (Japan), 10, e20240025, English, Domestic magazine
    Scientific journal

  • Hiroshi Kodama, Haruyuki Takaki, Yutaka Hirata, Eisuke Ueshima, Yasushi Kimura, Reona Wada, Keigo Osuga, Koichiro Yamakado
    BACKGROUND/AIM: A standard mouse model of pulmonary fibrosis has been created by intratracheal or intraperitoneal administration of bleomycin. However, a difficulty presented by this traditional method is its high mortality rate of more than 50% after bleomycin administration. In this study, we aimed to establish a unilateral lung disease model and to assess its feasibility and usefulness. MATERIALS AND METHODS: After 6-week-old C57BL/6 mice were anesthetized, a 1.7Fr microcatheter was advanced into the trachea using an otoscope. Then, 1.0 mg/kg of bleomycin was injected into bilateral lung at the trachea (n=13) or unilateral lung (n=14) after advancing the microcatheter to the left main bronchus under fluoroscopy. Body weight change and survival of bilateral and unilateral lung disease group mice at day 28 were compared using Mann-Whitney and log-rank tests. Lungs were extracted and evaluated using Masson trichrome staining. RESULTS: Body weights decreased 75.7%±14.0% in the bilateral lung disease group, but were greater, 94.1%±11.4%, in the unilateral lung disease group (p=0.03). Overall survival rates at day 28 were 30.8% and 85.7% in the bilateral and unilateral lung disease groups, respectively. Survival was significantly better in the unilateral lung disease model (p=0.01). Histological evaluation confirmed collagen deposition only in the bleomycin injected lung in the unilateral lung disease model. CONCLUSION: Establishing both a healthy and a diseased lung in the same individual model was feasible, achieving lessened body weight loss and more favorable survival. This technique allows for a more efficacious research design, where both the efficacy and adverse effects of a pharmaceutical agent can be evaluated in a single animal.
    2025, In vivo (Athens, Greece), 39(1) (1), 251 - 256, English, International magazine
    Scientific journal

  • Ryuji Shimada, Keitaro Sofue, Tianyuan Wang, Takeaki Ishihara, Eisuke Ueshima, Yoshiko Ueno, Akiko Kusaka, Takamichi Murakami
    Cine-magnetic resonance imaging (MRI) has been used to track respiratory-induced motion of the liver and tumor and assist in the accurate delineation of tumor volume. Recent developments in compressed sensitivity encoding (SENSE; CS) have accelerated temporal resolution while maintaining contrast resolution. This study aimed to develop and assess hepatobiliary phase (HBP) cine-MRI scans using CS. Phantom was imaged using cine-MRI and signal intensity (SI) and contrast ratio (CR) measured to determine the optimal flip-angle turbo field echo (TFE) prepulse delay. We performed cine-MRI in 20 patients for one minute, with images taken every 0.5 s after administration of gadoxetic acid contrast agent. Acquired images had three different acceleration factors (SENSE, CS without denoising [CS-no], and CS with strong denoising [CS-strong]). The image quality of the HBP cine MRI was quantitatively and qualitatively analyzed. In the phantom study, a flip angle of 30 °and TFE prepulse delay of 150 ms were optimal for clinical imaging. In a clinical study, CS-strong showed the highest signal-to-noise ratio and comparable contrast ratio among the three sequences. The CS-strong group showed a significantly higher image quality (P < 0.01), except for motion smoothness (P = 0.11). CS with denoising improved the tumor-to-liver contrast and image quality in high-temporal-resolution HBP cine MRI.
    Dec. 2024, Scientific reports, 14(1) (1), 31347 - 31347, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Eisuke Ueshima, Keitaro Sofue, Takahiro Kodama, Shuhei Yamamoto, Masato Komatsu, Shohei Komatsu, Nobuaki Ishihara, Akihiro Umeno, Takeru Yamaguchi, Masatoshi Hori, Takumi Fukumoto, Tetsuo Takehara, Takamichi Murakami
    INTRODUCTION: Immunotherapy is the first-line treatment for intermediate-advanced stage hepatocellular carcinoma (HCC), although its outcomes vary. This study aimed to identify imaging biomarkers of immunotherapy susceptibility linked to gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) and immune phenotypes, particularly immune-excluded phenotypes, with a tumor immune barrier. METHODS: We performed immunohistochemical staining with a CD8+ antibody, and samples were classified into immune-inflamed, -intermediate, -excluded, and -ignored phenotypes. We assessed EOB-MRI findings obtained from 104 patients who underwent hepatectomy for HCC and evaluated the relationship between MRI findings and immune phenotype. Spatial transcriptome analysis of tumor tissues in each immune phenotype was performed to characterize the MRI findings. For validation, we analyzed the treatment effect on 60 nodules in another cohort of 27 patients who received combined immunotherapy using anti-programmed death-ligand 1 and anti-vascular endothelial growth factor (VEGF) antibodies. RESULTS: HCCs with rim arterial phase hyperenhancement (APHE) (odds ratio [OR] 17.3, p = 0.009), peritumoral enhancement in the arterial phase (OR: 8.6, p < 0.004), and intermediate intensity on the hepatobiliary phase (HBP) measured with a visual 3-point scale (OR: 28.2, p = 0.002) were associated with immune-excluded phenotype, where tumors tended to be larger and of the single nodular type with extranodular growth and confluent multinodular rather than the simple nodular type. Spatial transcriptome analysis revealed a spatial relationship among cytotoxic T lymphocytes, VEGF signals, and cancer-associated fibroblasts at the tumor-invasive margins in this phenotype. From the validation study, nodules with any one of these three imaging findings had a significantly prolonged time to-nodular progression (p = 0.007, median not reached vs. 226 days). CONCLUSION: HCCs with rim APHE, peritumoral enhancement in arterial phase, and intermediate intensity on HBP with visual 3-point scale could be non-invasive biomarkers to predict the immune-excluded phenotype with the tumor immune barrier. These HCCs were most likely to respond to combined immunotherapy.
    Lead, Nov. 2024, Liver Cancer, 1(26) (26), 271 - 285, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Mika Miki, Atsuhiro Masuda, Mamoru Takenaka, Hideyuki Shiomi, Takao Iemoto, Hidetaka Tsumura, Masahiro Tsujimae, Hirochika Toyama, Keitaro Sofue, Eisuke Ueshima, Shunsuke Omoto, Akihiro Yoshida, Tomohiro Fukunaga, Hidekazu Tanaka, Ryota Nakano, Shogo Ota, Takashi Kobayashi, Arata Sakai, Maki Kanzawa, Tomoo Itoh, Yuzo Kodama
    BACKGROUND: Focal pancreatic parenchymal atrophy (FPPA) and upstream pancreatic atrophy (UPA) may indicate the presence of early pancreatic cancer. In early pancreatic cancer, the tumor occasionally spreads laterally along the main pancreatic duct, presenting challenges in determining the extent of surgical resection. This study aimed to investigate the association of pancreatic atrophy pattern and intraductal cancer extension. METHODS: Thirty-two patients with early-stage pancreatic cancer who underwent surgery at five participating centers were enrolled. Pancreatic atrophy was defined as the narrowing of parenchyma compared to the surrounding parenchyma and was classified as either FPPA (partial atrophy surrounding the pancreatic duct stenosis) or UPA (global atrophy caudal to the site of duct stenosis). Intraductal cancer extension was defined as an extension exceeding 10 mm. RESULTS: Preoperative computed tomography revealed FPPA, UPA, and no parenchymal atrophy in 13, 13, and 6 patients. Cases with FPPA or UPA showed significantly longer cancer extensions than those without atrophy (P = 0.005 and P = 0.03, respectively). Intraductal cancer extension was present in all but one case of FPPA. 69% (9/13) of the cases with UPA showed intraductal cancer extension, whereas cases without atrophy showed no intraductal cancer extension. Importantly, two patients with FPPA or UPA showed positive resection margins during surgery and three patients with FPPA or UPA showed recurrence in the remnant pancreas. CONCLUSIONS: The presence of FPPA and UPA indicates lateral cancer extension in early-stage pancreatic cancer. Preoperative assessment of the pancreatic parenchyma may provide valuable insights for determining the extent of surgical resection.
    Sep. 2024, Journal of gastroenterology, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Tomoyuki Gentsu, Masato Yamaguchi, Koji Sasaki, Ryota Kawasaki, Hiroki Horinouchi, Tetsuya Fukuda, Naokazu Miyamoto, Takeki Mori, Noriaki Sakamoto, Kensuke Uotani, Takanori Taniguchi, Yojiro Koda, Katsuhiro Yamanaka, Hiroaki Takahashi, Kenji Okada, Taro Hayashi, Toshitaka Watanabe, Yoshikatsu Nomura, Keigo Matsushiro, Eisuke Ueshima, Takuya Okada, Koji Sugimoto, Takamichi Murakami
    PURPOSE: The purpose of the study was to evaluate the efficacy and safety of pre-emptive transcatheter arterial embolization (P-TAE) of aortic side branches to prevent type II endoleak in patients with abdominal aortic aneurysm after endovascular abdominal aneurysm repair (EVAR). MATERIALS AND METHODS: This multicenter, prospective, single-arm trial enrolled 100 patients with abdominal aortic aneurysm from nine hospitals between 2018 and 2021. There were 85 men and 15 women, with a mean age of 79.6 ± 6.0 (standard deviation) years (range: 65-97 years). P-TAE was attempted for patent aortic side branches, including the inferior mesenteric artery, lumbar arteries, and other branches. The primary endpoint was late type II endoleak incidence at 6 months post-repair. Secondary endpoints included changes in aneurysmal sac diameter at 6- and 12 months, complications, re-intervention, and aneurysm-related mortality. Aneurysm sac changes at 6- and 12 months was compared between the late and no-late type II endoleak groups. RESULTS: Coil embolization was successful in 80.9% (321/397) of patent aortic side branches, including 86.3% of the inferior mesenteric arteries, 80.3% of lumbar arteries, and 55.6% of other branches without severe adverse events. Late type II endoleak incidence at 6 months was 8.9% (8/90; 95% confidence interval: 3.9-16.8%). Aneurysm sac shrinkage > 5 mm was observed in 41.1% (37/90) and 55.3% (47/85) of the patients at 6- and 12-months post-EVAR, respectively. Patients with late type II endoleak had less aneurysm sac shrinkage than those without type II endoleak at 12 months (-0.2 mm vs. -6.0 mm; P = 0.040). No patients required re-intervention for type II endoleak, and no aneurysm-related mortalities occurred. CONCLUSION: P-TAE is safe and effective in preventing type II endoleak, leading to early sac shrinkage at 12 months following EVAR.
    Sep. 2024, Diagnostic and interventional imaging, 105(9) (9), 326 - 335, English, International magazine
    Scientific journal

  • 増田 充弘, 祖父江 慶太郎, 權田 真知, 黄 哲久, 三木 美香, 小林 隆, 酒井 新, 山口 尊, 上嶋 英介, 矢部 慎二, 梅野 晃弘, 戎 直哉, 村上 卓道, 児玉 裕三
    (一社)日本膵臓学会, Jul. 2024, 膵臓, 39(3) (3), A176 - A176, Japanese

  • Ryuji Shimada, Keitaro Sofue, Yoshiko Ueno, Tetsuya Wakayama, Takeru Yamaguchi, Eisuke Ueshima, Akiko Kusaka, Masatoshi Hori, Takamichi Murakami
    PURPOSE: To compare the utility of thin-slice fat-suppressed single-shot T2-weighted imaging (T2WI) with deep learning image reconstruction (DLIR) and conventional fast spin-echo T2WI with DLIR for evaluating pancreatic protocol. METHODS: This retrospective study included 42 patients (mean age, 70.2 years) with pancreatic cancer who underwent gadoxetic acid-enhanced MRI. Three fat-suppressed T2WI, including conventional fast-spin echo with 6 mm thickness (FSE 6 mm), single-shot fast-spin echo with 6 mm and 3 mm thickness (SSFSE 6 mm and SSFSE 3 mm), were acquired for each patient. For quantitative analysis, the SNRs of the upper abdominal organs were calculated between images with and without DLIR. The pancreas-to-lesion contrast on DLIR images was also calculated. For qualitative analysis, two abdominal radiologists independently scored the image quality on a 5-point scale in the FSE 6 mm, SSFSE 6 mm, and SSFSE 3 mm with DLIR. RESULTS: The SNRs significantly improved among the three T2-weighted images with DLIR compared to those without DLIR in all patients (P < 0.001). The pancreas-to-lesion contrast of SSFSE 3 mm was higher than those of the FSE 6 mm (P < 0.001) and tended to be higher than SSFSE 6 mm (P = 0.07). SSFSE 3 mm had the highest image qualities regarding pancreas edge sharpness, pancreatic duct clarity, and overall image quality, followed by SSFSE 6 mm and FSE 6 mm (P < 0.0001). CONCLUSION: SSFSE 3 mm with DLIR demonstrated significant improvements in SNRs of the pancreas, pancreas-to-lesion contrast, and image quality more efficiently than did SSFSE 6 mm and FSE 6 mm. Thin-slice fat-suppressed single-shot T2WI with DLIR can be easily implemented for pancreatic MR protocol.
    Jun. 2024, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hideki Kunichika, Kiyoyuki Minamiguchi, Tetsuya Tachiiri, Kozo Shimizu, Ryosuke Taiji, Aya Yamada, Ryota Nakano, Mariko Irizato, Satoshi Yamauchi, Aki Marugami, Nagaaki Marugami, Hayato Kishida, Hiroyuki Nakagawa, Megumi Takewa, Ken Kageyama, Akira Yamamoto, Eisuke Ueshima, Keitaro Sofue, Ryuichi Kita, Hiroyuki Kurakami, Toshihiro Tanaka
    BACKGROUND: This study aimed to examine whether the coefficient of variation (CV) in the hepatobiliary-phase (HBP) of Gd-EOB-DTPA-MRI could be an independent predictive factor for tumor progression. METHODS: Patients who underwent Gd-EOB-DTPA-MRI before Atezolizumab/bevacizumab therapy at six affiliated institutions between 2018 and 2022 were included. CV for each patient was calculated as the mean value for up to five tumors larger than 10 mm, and CV of the whole tumor was calculated using LIFEx software. The tumor response was evaluated within 6-10 weeks. The primary endpoint was to investigate the predictive factors, including CV, related to tumor progression using logistic regression analysis. The secondary endpoints were tumor response rate and progression-free survival (PFS) based on CV. RESULTS: Of the 46 enrolled patients, 13 (28.3%) underwent early progressive disease. Multivariate analysis revealed that a high CV (≥0.22) was an independent predictive factor for tumor progression (p = 0.043). Patients with a high CV had significantly frequent PD than those with a low CV (43.5 vs. 13.0%, p = 0.047). Patients with a high CV tended to have shorter PFS than those with a low CV (3.5 vs. 6.7 months, p = 0.071). CONCLUSION: Quantitative analysis using CV in the HBP of Gd-EOB-DTPA-MRI may be useful for predicting tumor progression for atezolizumab/bevacizumab therapy.
    Jun. 2024, Cancers, 16(12) (12), English, International magazine
    Scientific journal

  • Koji Sasaki, Masato Yamaguchi, Tomoyuki Gentsu, Ryota Kawasaki, Naokazu Miyamoto, Kensuke Uotani, Noriaki Sakamoto, Tetsuya Fukuda, Hiroki Horinouchi, Takanori Taniguchi, Takeki Mori, Yojiro Koda, Katsuhiro Yamanaka, Hiroaki Takahashi, Kenji Okada, Toshitaka Watanabe, Taro Hayashi, Yoshikatsu Nomura, Keigo Matsushiro, Eisuke Ueshima, Takuya Okada, Koji Sugimoto, Takamichi Murakami
    PURPOSE: To evaluate the effectiveness and safety of pre-emptive transcatheter arterial embolization (P-TAE) for aortic side branches (ASBs) to prevent Type 2 endoleaks (EL2) before endovascular aneurysm repair (EVAR) using the Excluder stent-graft system (Excluder). MATERIALS AND METHODS: In this prospective, multicenter study, 80 patients (mean age, 79.1 years [SD ± 6.7]; 85.0% were men; mean aneurysmal sac diameter, 48.4 mm [SD ± 7.4]) meeting the eligibility criteria were prospectively enrolled from 9 hospitals. Before EVAR, P-TAE was performed to embolize the patent ASBs originating from the abdominal aortic aneurysm. Contrast-enhanced computed tomography (CT) was performed at 1 month and 6 months after EVAR. The primary endpoint was EL2 incidence at 6 months, and the secondary endpoints were aneurysmal sac diameter changes at 6 and 12 months, P-TAE outcomes, adverse events related to P-TAE, reintervention, and aneurysm-related mortality. RESULTS: All patients successfully underwent P-TAE without serious. Coil embolization was successful in 81.6% of ASBs. EL2 incidence at 6 months was identified in 18 of 70 (25.7%) patients. Aneurysmal sac diameter shrinkage (≥5 mm) was observed in 30.0% of patients at 6 months and in 40.9% at 12 months. Only 1 patient required reintervention for EL2 within 1 year of EVAR; aneurysm-related deaths were not observed. CONCLUSIONS: P-TAE for ASBs before EVAR using Excluder is a safe and effective strategy. It aids in achieving early aneurysmal sac shrinkage and reduces EL2 reintervention at 1 year after EVAR.
    Jun. 2024, Journal of vascular and interventional radiology : JVIR, 35(6) (6), 874 - 882, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takeru Yamaguchi, Keitaro Sofue, Eisuke Ueshima, Naoki Sugiyama, Shinji Yabe, Yoshiko Ueno, Atsuhiro Masuda, Hirochika Toyama, Takayuki Kodama, Masato Komatsu, Masatoshi Hori, Takamichi Murakami
    This study investigated the utility of imaging features, such as rim enhancement on contrast-enhanced CT (CECT), in predicting the prognosis of pancreatic ductal adenocarcinoma (PDAC). This retrospective study included 158 patients (84 men; mean age, 68 years) with pathologically confirmed PDAC. The following imaging features were evaluated on CECT by two radiologists: tumor size, tumor attenuation, and the presence of rim enhancement. Cox proportional hazards analysis was performed to identify the imaging and clinicopathological features for predicting disease-free survival (DFS) and overall survival (OS). Pathological features were compared with the presence of rim enhancement. Among the 158 patients, 106 (67%) underwent curative surgery (surgery group) and 52 (33%) received conservative treatment (non-surgery group). Rim enhancement was observed more frequently in the non-surgery group than in the surgery group (44% vs. 20%; p < 0.001). Rim enhancement showed significant associations with shorter DFS and OS in the surgery group (hazard ratios (HRs), 3.03 and 2.99; p < 0.001 and p = 0.003, respectively), whereas tumor size showed significant associations with shorter OS (HR per 1 mm increase, 1.08; p < 0.001). PDACs with rim enhancement showed significant associations with higher histological tumor grades (p < 0.001). PDAC with rim enhancement on CECT could predict poorer prognosis and more aggressive tumor grades.
    MDPI AG, Apr. 2024, Diagnostics, 14(8) (8), 782 - 782
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 無再発のガン患者の血液中のexosome由来のmicroRNAのガン細胞増殖抑制作用
    平田 豊, 高木 治行, 上嶋 英介, 児玉 大志, 和田 玲緒名, 山門 亨一郎
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2024, 日本インターベンショナルラジオロジー学会雑誌, 39(Suppl.) (Suppl.), 253 - 253, Japanese

  • Masashi Tajiri, Tomoyuki Gentsu, Masato Yamaguchi, Koji Sasaki, Eisuke Ueshima, Takuya Okada, Koji Sugimoto, Takamichi Murakami
    We report a case of a life-threatening ruptured renal angiomyolipoma (AML) that did not meet the criteria for prophylactic treatment (tumor >4 cm or intratumoral aneurysm >5 mm) during follow-up. A woman in her 70s was followed up for a 2.5-cm AML with a rich vascular component. An intratumoral aneurysm >5 mm was not identified for 2 years. She complained of a sudden abdominal pain with hypotension, and contrast-enhanced computed tomography revealed a retroperitoneal hematoma with contrast media extravasation from an intratumoral aneurysm. Emergency transcatheter arterial embolization was successfully performed using N-butyl cyanoacrylate glue. Rupture can occur in small AMLs or in AMLs not identified with intratumoral aneurysms during follow-up. AMLs with a rich vascular component at the kidney surface are more likely to rupture.
    Mar. 2024, Interventional radiology (Higashimatsuyama-shi (Japan), 9(1) (1), 20 - 25, English, Domestic magazine

  • Nobuaki Ishihara, Shohei Komatsu, Keitaro Sofue, Eisuke Ueshima, Yoshihiko Yano, Yoshimi Fujishima, Jun Ishida, Masahiro Kido, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Hiroaki Yanagimoto, Hirochika Toyama, Yoshihide Ueda, Yuzo Kodama, Takamichi Murakami, Takumi Fukumoto
    AIM: The IMbrave150 trial revealed that atezolizumab plus bevacizumab (AtezoBv) showed a higher objective response rate (ORR) in patients with advanced hepatocellular carcinoma (HCC). Although conversion therapy after AtezoBv has been recently reported, markers predictive of its efficacy, particularly radiological imaging markers, have not yet been identified. The present study focused on tumor morphological appearance on radiological imaging and evaluated whether it could be associated with AtezoBv efficacy. METHODS: Ninety-five intrahepatic lesions in 74 patients who were given AtezoBv for advanced HCC were recruited for evaluation. The lesions were divided into two groups, simple nodular (SN group) and non-simple nodular (non-SN group), based on the gross morphology on pretreatment imaging, and retrospectively evaluated for treatment response and other relevant clinical outcomes. RESULTS: Assessing the size of individual tumors after treatment, waterfall plots showed that tumor shrinkage in the non-SN group including 56 lesions was higher than that in the SN group comprising 39 lesions. The ORR was significantly higher in the non-SN group (39.3% vs. 15.4%, p = 0.012). Additionally, the median time to nodular progression was longer in the non-SN group (21.0 months vs. 8.1 months, p = 0.119) compared to the SN group. Six patients with non-SN lesions underwent sequential local therapy. CONCLUSIONS: Atezolizumab plus bevacizumab may show increased therapeutic efficacy in patients with tumors with a higher potential for aggressive oncological behavior, such as non-SN lesions. Treatment strategies focusing on conversion therapy may be crucial in patients with non-SN lesions.
    Feb. 2024, Hepatology research : the official journal of the Japan Society of Hepatology, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 仙骨に発生した褐色脂肪腫の1例
    重安 奈央子, 神田 知紀, 西岡 瑛子, 佐々木 康二, 元津 倫幸, 上嶋 英介, 上野 嘉子, 西尾 瑞穂, 橋村 宏美, 岡田 卓也, 祖父江 慶太郎, 河野 淳, 野上 宗伸, 山口 雅人, 堀 雅敏, 杉本 幸司, 村上 卓道, 小松 正人
    (公社)日本医学放射線学会, Feb. 2024, Japanese Journal of Radiology, 42(Suppl.) (Suppl.), 32 - 32, Japanese

  • 佐々木 康二, 岡田 卓也, 山口 雅人, 岡本 雄太郎, 松代 啓吾, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Jan. 2024, 日本インターベンショナルラジオロジー学会雑誌, 38(3) (3), 166 - 175, Japanese

  • 佐々木 康二, 岡田 卓也, 山口 雅人, 岡本 雄太郎, 松代 啓吾, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Jan. 2024, 日本インターベンショナルラジオロジー学会雑誌, 38(3) (3), 166 - 175, Japanese

  • Keitaro Sofue, Ryuji Shimada, Eisuke Ueshima, Shohei Komatsu, Takeru Yamaguchi, Shinji Yabe, Yoshiko Ueno, Masatoshi Hori, Takamichi Murakami
    XMLink, 2024, Korean Journal of Radiology, 25(1) (1), 24 - 24
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 岡田 卓也, 佐々木 康二, 岡本 雄太郎, 松代 啓吾, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Oct. 2023, 日本インターベンショナルラジオロジー学会雑誌, 38(1) (1), 16 - 23, Japanese

  • 岡田 卓也, 佐々木 康二, 岡本 雄太郎, 松代 啓吾, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Oct. 2023, 日本インターベンショナルラジオロジー学会雑誌, 38(1) (1), 16 - 23, Japanese

  • Eisuke Ueshima, Keitaro Sofue, Haruyuki Takaki, Yutaka Hirata, Hiroshi Kodama, Takuya Okada, Masato Yamaguchi, Koichiro Yamakado, Takamichi Murakami
    PURPOSE: This study aimed to investigate the impact of transarterial embolization (TAE) on macrophage polarization and the modulatory effect of lenvatinib in combination with TAE in a rat hepatocellular carcinoma model. MATERIALS AND METHODS: A rat N1S1-bearing orthotopic model was subjected to TAE and administered 5 mg/kg of lenvatinib. CD8+, CD68+, and CD206+ cells were examined in four cohorts: sham (n=5), lenvatinib (n=5), TAE (n=5), and a combination of TAE and lenvatinib (n=5). Transcriptome analysis was performed to assess gene expression related to macrophage polarization in the sham, TAE, and combination groups. An in vitro co-culture experiment with bone marrow-derived macrophages was performed to identify lenvatinib target in macrophage polarization. RESULTS: There were no significant differences in the number of CD8+ and CD68+ cells among the four groups. Tumor-associated macrophage positivity for CD206 was significantly higher in the TAE group (58.1 ± 20.9) than in the sham (11.2 ± 14.3, P < 0.001) and combination (27.1 ± 19.7, P = 0.003) groups. In the transcriptome analysis, compared with those in the sham group, five macrophage polarization-related genes, including St6gal1, were upregulated by more than 1.5-fold in the TAE group and downregulated by more than 1.5-fold in the combination group. The co-culture experiment showed that lenvatinib did not affect macrophages but N1S1 cells, leading to macrophage polarization. CONCLUSION: TAE induced M2 macrophage polarization. Lenvatinib administration with TAE could reprogram macrophage polarization, improving tumor immune microenvironment.
    Lead, Jul. 2023, Journal of vascular and interventional radiology : JVIR, English, International magazine
    Scientific journal

  • Yoshihide Nanno, Hirochika Toyama, Eisuke Ueshima, Keitaro Sofue, Ippei Matsumoto, Jun Ishida, Takeshi Urade, Kenji Fukushima, Hidetoshi Gon, Daisuke Tsugawa, Shohei Komatsu, Kaori Kuramitsu, Tadahiro Goto, Sadaki Asari, Hiroaki Yanagimoto, Masahiro Kido, Tetsuo Ajiki, Takumi Fukumoto
    Transarterial chemoembolization (TACE) is performed for pancreatic neuroendocrine tumor (PanNEN) liver metastases; however, the safety and efficacy of TACE procedures, especially for patients who have undergone previous pancreatic surgery, have not been established. We reviewed 48 TACE procedures (1-6 procedures/patient) performed on 11 patients with PanNEN liver metastases, including 16 TACE procedures (4-6 procedures/patient) for 3 patients with a history of biliary-enteric anastomosis. The overall tumor objective response rate was 94%. The incidence of Clavien‒Dindo grade ≥ 2 complications was 1/16 (6%) and 1/32 (3%), and the median time to untreatable progression was 31 (14-41) and 27 (2-60) months among patients with and without a history of biliary-enteric anastomosis, respectively. Although validation is needed in future studies, our experiences have shown that TACE treatment is a viable treatment option for PanNEN liver metastases, even after biliary-enteric anastomosis with experienced teams and careful patient follow-up.
    Jun. 2023, Surgery today, English, Domestic magazine
    Scientific journal

  • 佐々木 康二, 岡田 卓也, 松永 直樹, 松代 啓吾, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, May 2023, 日本インターベンショナルラジオロジー学会雑誌, 37(2) (2), 110 - 116, Japanese

  • 佐々木 康二, 岡田 卓也, 松永 直樹, 松代 啓吾, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, May 2023, 日本インターベンショナルラジオロジー学会雑誌, 37(2) (2), 110 - 116, Japanese

  • Eiko Nishioka, Keitaro Sofue, Koji Maruyama, Eisuke Ueshima, Yoshiko Ueno, Masakatsu Tsurusaki, Shohei Komatsu, Takumi Fukumoto, Takamichi Murakami
    To assess the value of nonenhancing capsule by adding to enhancing capsule in gadoxetic acid-enhanced MRI (EOB-MRI) in comparison with contrast-enhanced CT (CE-CT) for diagnosing histological capsule in hepatocellular carcinoma (HCC). One-hundred fifty-one patients with HCC who underwent both CE-CT and EOB-MRI were retrospectively reviewed. Liver Imaging-Reporting and Data System (LI-RADS) v2018 imaging features, including enhancing and nonenhancing capsule were evaluated by two readers in CE-CT and EOB-MRI. Frequencies of each imaging feature were compared between CE-CT and EOB-MRI. The area under the receiver operating characteristic (AUC) curve for the diagnosis of histological capsule was compared across the following three imaging criteria: (1) enhancing capsule in CE-CT, (2) enhancing capsule in EOB-MRI, and (3) enhancing/nonenhancing capsule in EOB-MRI. Enhancing capsule in EOB-MRI was significantly less frequently depicted than that in CE-CT (p < 0.001 and = 0.016 for reader 1 and 2). Enhancing/nonenhancing capsule in EOB-MRI achieved a similar frequency of enhancing in CE-CT (p = 0.590 and 0.465 for reader 1 and 2). Adding nonenhancing capsule to enhancing capsule in EOB-MRI significantly increased AUCs (p < 0.001 for both readers) and achieved similar AUCs compared with enhancing capsule in CE-CT (p = 0.470 and 0.666 for reader 1 and 2). Adding nonenhancing capsule to the definition of capsule appearance can improve the diagnosis of capsule in EOB-MRI for the diagnosis of histological capsule in HCC and decrease discordance of capsule appearance between EOB-MRI and CE-CT.
    Apr. 2023, Scientific reports, 13(1) (1), 6113 - 6113, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 術前大動脈分枝塞栓術を併用したEVAR(EXCLUDER)の一年成績 多施設共同前向き研究(One-year results of EVAR(EXCLUDER) with side branch embolization: A prospective multicenter study)
    佐々木 康二, 山口 雅人, 元津 倫幸, 川崎 竜太, 堀之内 宏樹, 坂本 憲昭, 魚谷 健祐, 宮本 直和, 福田 哲也, 谷口 尚範, 森 岳樹, 上嶋 英介, 岡田 卓也, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2023, 日本インターベンショナルラジオロジー学会雑誌, 38(Suppl.) (Suppl.), 175 - 175, English

  • 肝細胞癌肉眼分類とアテゾリズマブ・ベバシズマブ併用療法の治療効果に関する検討
    石原 伸朗, 小松 昇平, 祖父江 慶太郎, 矢野 嘉彦, 木戸 正浩, 蔵満 薫, 権 英寿, 福島 健司, 浦出 剛史, 山本 淳史, 上嶋 英介, 津川 大介, 後藤 直大, 浅利 貞毅, 上田 佳秀, 味木 徹夫, 福本 巧
    (一社)日本肝臓学会, Apr. 2023, 肝臓, 64(Suppl.1) (Suppl.1), A385 - A385, Japanese

  • 有痛性脊椎転移に対する経皮的椎体形成術の有効性に関与する因子の検討
    松代 啓吾, 岡田 卓也, 八幡 宥徳, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2023, 日本インターベンショナルラジオロジー学会雑誌, 38(Suppl.) (Suppl.), 140 - 140, Japanese

  • 術前大動脈分枝塞栓術を併用したEVAR(EXCLUDER)の一年成績 多施設共同前向き研究(One-year results of EVAR(EXCLUDER) with side branch embolization: A prospective multicenter study)
    佐々木 康二, 山口 雅人, 元津 倫幸, 川崎 竜太, 堀之内 宏樹, 坂本 憲昭, 魚谷 健祐, 宮本 直和, 福田 哲也, 谷口 尚範, 森 岳樹, 上嶋 英介, 岡田 卓也, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2023, 日本インターベンショナルラジオロジー学会雑誌, 38(Suppl.) (Suppl.), 175 - 175, English

  • Yushi Tsujita, Keitaro Sofue, Eisuke Ueshima, Yoshiko Ueno, Masatoshi Hori, Masakatsu Tsurusaki, Takamichi Murakami
    The incidence of hepatocellular carcinoma (HCC) is still on the rise in North America and Europe and is the second leading cause of cancer-related mortality. The treatment of HCC varies, with surgery and locoregional therapy (LRT) such as radiofrequency ablation and transcatheter arterial chemoembolization, and radiation therapy being the primary treatment. Currently, systemic therapy with molecular-targeted agents and immune checkpoint inhibitors (ICIs) is becoming a major treatment option for the unresectable HCC. As the HCC after LRT or systemic therapy often remains unchanged in size and shows loss of contrast effect in contrast-enhanced CT or MRI, the response evaluation criteria in solid tumors (RECIST) and World Health Organization criteria, which are usually used to evaluate the treatment response of solid tumors, are not appropriate for HCC. The modified RECIST (mRECIST) and the European Association for the Study of the Liver (EASL) criteria were developed for HCC, with a focus on viable lesions. The latest 2018 edition of the Liver Imaging Reporting and Data System (LI-RADS) also includes a section on the evaluation of treatment response. The cancer microenvironment influences the therapeutic efficacy of ICIs. Several studies have examined the utility of gadoxetic acid-enhanced MRI for predicting the pathological and molecular genetic patterns of HCC. In the future, it may be possible to stratify prognosis and predict treatment response prior to systemic therapy by using pre-treatment imaging findings.
    Apr. 2023, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 22(2) (2), 209 - 220, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Shinji Yabe, Keitaro Sofue, Masatoshi Hori, Tomoki Maebayashi, Megumi Nishigaki, Yushi Tsujita, Takeru Yamaguchi, Eisuke Ueshima, Yoshiko Ueno, Takamichi Murakami
    PURPOSE: To investigate the added value of contrast enhancement boost (CE-boost) images in multiphasic contrast-enhanced CT (CE-CT) for diagnosing small (<20 mm) hypervascular hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This retrospective study included 69 patients (age, 74 ± 8 years; 52 men) with 70 hypervascular HCCs (<20 mm) who underwent multiphasic CE-CT (pre-contrast, late arterial phase [LAP], portal venous phase [PVP], and equilibrium phase). Two types of CE-boost images were generated by subtracting PVP from LAP (LA-PV) images and LAP from PVP (PV-LA) images to enhance the contrast effect of hepatic arterial and portal venous perfusion more selectively. Tumor-to-liver contrast-to-noise ratios (CNRs) in CE-boost images were compared with those in CE-CT images using the Wilcoxon signed-rank test. Two independent readers reviewed the imaging datasets: CE-CT alone and CE-CT with CE-boost images. The diagnostic performance of each dataset was compared using jackknife alternative free-response receiver operating characteristics (JAFROC-1). RESULTS: The tumor-to-liver CNRs in the LA-PV (6.4 ± 3.0) and PV-LA (-3.3 ± 2.1) images were greater than those in the LAP (3.2 ± 1.7) and PVP images (-1.1 ± 1.4) (p <.001 for both). The reader-averaged figures of merit were 0.751 for CE-CT alone and 0.807 for CE-CT with CE-boost images (p <.001). Sensitivities increased by adding CE-boost images for both readers (p <.001 and = 0.03), while positive predictive values were equivalent (p >.99). CONCLUSION: Adding CE-boost images to multiphasic CE-CT can improve the diagnostic accuracy and sensitivity for small hypervascular HCC by increasing the tumor-to-liver CNR.
    Mar. 2023, European journal of radiology, 160, 110696 - 110696, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 元津 倫幸, 山口 雅人, 松代 啓吾, 佐々木 康二, 上嶋 英介, 岡田 卓也, 杉本 幸司, 村上 卓道, 中井 秀和, 山中 勝弘, 岡田 健次, 川崎 竜太
    (一社)日本インターベンショナルラジオロジー学会, Feb. 2023, 日本インターベンショナルラジオロジー学会雑誌, 37(1) (1), 2 - 12, Japanese

  • Hirata Yutaka, Takaki Haruyuki, Kodama Hiroshi, Ueshima Eisuke, Yamakado Koichiro, Oku Yoshitaka
    【Purpose】 To search for microRNAs that prevent cancer recurrence from exosomes in the blood of cancer patients undergoing IVR (Interventional Radiology), and to develop new nucleic acid drugs for cancer. 【Subjects】 Blood of recurrent and non-recurrent cancer patients after IVR, and healthy subjects. 【Methods】 Exosomes were extracted from the blood of cancer patients and healthy subjects, and RNA was purified. Furthermore, microRNA was detected by GeneChip miRNA 4.0 Array analysis. In addition, microRNA mimic was transfected into colon cancer cells (HCT116), and the viability of cancer cells was evaluated by Calcein/PI fluorescence staining. 【Results】 MicroRNA expression patterns were different in exosomes in the blood of recurrent cancer patients, non-recurrent cancer patients, and healthy subjects. Furthermore, we found 18 microRNAs with significantly more than 3-fold abundance in non-recurrent cancer patients. Among the 18 microRNA mimics, 3 microRNAs reduced cancer cell viability to less than 20%. 【Summary】 Since exosomal microRNA in the blood of non-recurrence-free cancer patients markedly decreased the viability of cancer cells, it is expected as a novel nucleic acid drug to prevent recurrence of cancer.
    Japanese Pharmacological Society, 2023, Proceedings for Annual Meeting of The Japanese Pharmacological Society, 97, 3-B-P-056, Japanese

  • Takashi Sugimoto, Yuko Ono, Eisuke Ueshima, Keigo Matsushiro, Isamu Yamada, Joji Kotani
    BACKGROUND: The kidneys are one of the organs most commonly affected by blunt trauma; however, the anatomical variations that predispose kidney injury are poorly understood. CASE PRESENTATION: An 80-year-old Japanese woman with lumber scoliosis was brought to our hospital because of severe flank pain after a minor fall at home. Contrast-enhanced computed tomography showed a severe left kidney laceration at the level of an acute angle in the vertebral column caused by scoliosis. Extravasation of contrast medium from the left renal artery branches was also noted. Selective arterial embolization achieved hemostasis. The patient was transferred to a rehabilitation facility without sequelae. CONCLUSION: Patients with scoliosis could be at higher risk of severe kidney laceration because of intrusion of the vertebral column into the retroperitoneal space. Therefore, even after low-impact trauma, active exploration for kidney injury could be warranted in patients with spinal curvature disorders.
    2023, Acute medicine & surgery, 10(1) (1), e816, English, International magazine
    Link to Kobe Univ. Repository (Kernel)

  • Akiyo Fukutomi, Keitaro Sofue, Eisuke Ueshima, Noriyuki Negi, Yoshiko Ueno, Yushi Tsujita, Shinji Yabe, Takeru Yamaguchi, Ryuji Shimada, Akiko Kusaka, Masatoshi Hori, Takamichi Murakami
    Springer Science and Business Media LLC, Sep. 2022, European Radiology, 33(2) (2), 1388 - 1399
    Scientific journal

  • Yuko Ono, Eisuke Ueshima, Nobuto Nakanishi, Kazuaki Shinohara, Isamu Yamada, Joji Kotani
    BACKGROUND: Thyrocervical trunk rupture is an unusual, but critical, complication associated with central venous catheter (CVC) placement. The management of this complication has not been fully determined because it is rare. CASE PRESENTATION: A 53-year-old Japanese woman with anorexia nervosa developed refractory ventricular fibrillation. After returning spontaneous circulation, a CVC was successfully placed at the initial attempt in the right internal jugular vein using real-time ultrasound guidance. Immediately after CVC placement, she developed enlarging swelling around the neck. Contrast-enhanced computed tomography showed massive contrast media extravasation around the neck and mediastinum. Brachiocephalic artery angiography showed a "blush" appearance of the ruptured right thyrocervical trunk. After selective arterial embolization with 33% N-butyl-2-cyanoacrylate, the extravasation completely disappeared and hemostasis was achieved. CONCLUSION: Our findings suggest that severe vascular complications arising from CVC placement can occur in patients with a fragile physiological state. Endovascular embolization is an effective treatment for such complications.
    Sep. 2022, JA clinical reports, 8(1) (1), 74 - 74, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takeshi Urade, Masahiro Kido, Kaori Kuramitsu, Shohei Komatsu, Takuya Mizumoto, Eisuke Ueshima, Koji Sasaki, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto
    Springer Science and Business Media LLC, Sep. 2022, Clinical Journal of Gastroenterology
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Naoki Matsunaga, Takuya Okada, Yuko Ono, Keigo Matsushiro, Koji Sasaki, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Masato Yamaguchi, Koji Sugimoto, Takamichi Murakami
    Abstract Background Spinal fractures rarely cause hemothorax, and no treatment consensus has been reached. Conservative treatment is generally selected in cases without arterial injury, but there have been some reports of uncontrolled bleeding. Here we report a case of hemothorax caused by spinal fracture without arterial injury treated with transcatheter arterial embolization. Case presentation An 88-year-old Japanese woman with back pain was diagnosed with hemothorax due to bleeding from an unstable fracture of the tenth thoracic vertebra. Contrast-enhanced computed tomography revealed no obvious arterial injury. We performed transcatheter arterial embolization of the bilateral tenth intercostal arteries to prevent rebleeding. The hemothorax did not worsen until surgical spinal fixation 9 days post-transcatheter arterial embolization, and she was discharged 30 days after admission. Conclusion Transcatheter arterial embolization for hemothorax caused by spinal fractures without obvious arterial injury may be a useful bridge to spinal fixation.
    Springer Science and Business Media LLC, Sep. 2022, Journal of Medical Case Reports, 16(1) (1)
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 脈管奇形・リンパ管の画像診断と治療戦略(診断) 画像診断から判断する脈管奇形の治療戦略 形成外科医の立場から
    野村 正, 上嶋 英介, 祖父江 慶太郎, 寺師 浩人
    (公社)日本医学放射線学会, Sep. 2022, 日本医学放射線学会秋季臨床大会抄録集, 59回, S308 - S308, Japanese

  • 【Intermediate stage HCCに対するTACE】TACEにおける腫瘍微小環境の変化と分子標的薬・免疫治療併用の意義
    上嶋 英介, 祖父江 慶太郎, 松代 啓吾, 佐々木 康二, 元津 倫幸, 岡田 卓也, 山口 雅人, 杉本 幸司, 村上 卓道
    腫瘍の微小環境は血管、線維芽細胞、免疫細胞、細胞外器質等の複数の細胞・構造から構成されている。肝細胞癌に対する経皮的動脈化学塞栓術(TACE)が腫瘍微小環境(血管新生、代謝ストレス、免疫逃避)に与える影響について概説した。TACEと分子標的薬(血管新生阻害薬の抗VEGF抗体、チロシンキナーゼ阻害薬)との併用効果、免疫療法(免疫チェックポイント阻害薬)との併用効果について述べた。
    (一社)日本インターベンショナルラジオロジー学会, Aug. 2022, 日本インターベンショナルラジオロジー学会雑誌, 36(3) (3), 244 - 253, Japanese

  • Timo A Auer, Keitaro Sofue, Eisuke Ueshima, Nina Rauer, Takeru Yamaguchi, Bernhard Gebauer, Bernd Hamm, Takamichi Murakami, Christian Althoff
    Informa UK Limited, Aug. 2022, Journal of Hepatocellular Carcinoma, Volume 9, 695 - 705
    Scientific journal

  • Hidetoshi Gon, Daisuke Tsugawa, Hiroaki Yanagimoto, Eisuke Ueshima, Takuya Mizumoto, Shinichi So, Hirochika Toyama, Masahiro Kido, Tetsuo Ajiki, Takumi Fukumoto
    Portal vein thrombosis (PVT) is a lethal complication of hepatectomy if not properly treated. An 81-year-old woman diagnosed with postoperative PVT after right hepatectomy and caudate lobectomy for perihilar cholangiocarcinoma. Elevation of serum total bilirubin levels, D-dimer levels, and glossy ascites appeared on postoperative day 5 (POD5), and a contrast-enhanced CT confirmed PVT. Thrombi were found from the umbilical portion of the portal vein to the superior mesenteric vein. There were signs of acute liver failure due to thrombi obstructing the portal vein. Therefore, emergent catheter thrombus aspiration was performed under laparotomy. An aspiration catheter was inserted into the superior mesenteric vein from the ileocolic vein. We performed direct aspiration thrombectomy, followed by anticoagulant administration using urokinase via the catheter. Partial recanalization of the portal vein and superior mesenteric vein was observed. To dissolve residual thrombi, edoxaban administration was started on POD6. Contrast-enhanced CT 16 days after her additional operation showed the thrombi had completely disappeared. The patient was discharged on POD76. She had no recurrence of PVT over the next 6 months. Combination therapy of early intervention using aspiration catheter and systemic anticoagulant medication was useful for severe postoperative PVT accompanied with liver failure.
    Jun. 2022, Clinical journal of gastroenterology, 15(5) (5), 981 - 987, English, Domestic magazine
    Scientific journal

  • Yushi Tsujita, Keitaro Sofue, Eisuke Ueshima, Yoshiko Ueno, Masatoshi Hori, Takamichi Murakami
    Viral hepatitis was previously the most common cause of chronic liver disease. However, in recent years, nonalcoholic fatty liver disease (NAFLD) cases have been increasing, especially in developed countries. NAFLD is histologically characterized by fat, fibrosis, and inflammation in the liver, eventually leading to cirrhosis and hepatocellular carcinoma. Although biopsy is the gold standard for the assessment of the liver parenchyma, quantitative evaluation methods, such as ultrasound, CT, and MRI, have been reported to have good diagnostic performances. The quantification of liver fat, fibrosis, and inflammation is expected to be clinically useful in terms of the prognosis, early intervention, and treatment response for the management of NAFLD. The aim of this review was to discuss the basics and prospects of MRI-based tissue quantifications of the liver, mainly focusing on proton density fat fraction for the quantification of fat deposition, MR elastography for the quantification of fibrosis, and multifrequency MR elastography for the evaluation of inflammation.
    May 2022, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • ラット肝細胞癌モデルにおける塞栓によるマクロファージの極性転換はレンバチニブによってリプログラムされ得る(Embolization Induced Macrophage Polarization can be Reprogrammed by Lenvatinib in Rat Hepatoma Model)
    Ueshima Eisuke, Sofue Keitaro, Takaki Haruyuki, Hirata Yutaka, Kodama Hiroshi, Hamada Mostafa, Matsushiro Keigo, Sasaki Koji, Gentsu Tomoyuki, Okada Takuya, Yamaguchi Masato, Yamakado Koichiro, Sugimoto Koji, Murakami Takamichi
    Lead, (一社)日本インターベンショナルラジオロジー学会, May 2022, 日本インターベンショナルラジオロジー学会雑誌, 37(Suppl.) (Suppl.), 238 - 238, English

  • エクスクルーダーによるEVAR前の予防的な大動脈側枝塞栓術 前向き多施設共同研究(Preemptive aortic side branch embolization before EVAR with EXCLUDER:A prospective multicenter study)
    Sasaki Koji, Yamaguchi Masato, Gentsu Tomoyuki, Kawasaki Ryota, Horinouchi Hiroki, Sakamoto Noriaki, Uotani Kensuke, Miyamoto Naokazu, Fukuda Tetsuya, Taniguchi Takanori, Mori Takeki, Ueshima Eisuke, Okada Takuya, Sugimoto Koji, Murakami Takamichi
    (一社)日本インターベンショナルラジオロジー学会, May 2022, 日本インターベンショナルラジオロジー学会雑誌, 37(Suppl.) (Suppl.), 271 - 271, English

  • ENDURANTによるEVAR前の大動脈側枝塞栓術の先取り 多施設共同プロスペクティブ研究(Preemptive aortic side branch embolization before EVAR with ENDURANT: A prospective multicenter study)
    Gentsu Tomoyuki, Yamaguchi Masato, Sasaki Koji, Kawasaki Ryota, Horinouchi Hiroki, Sakamoto Noriaki, Uotani Kensuke, Miyamoto Naokazu, Fukuda Tetsuya, Taniguchi Takanori, Mori Takeki, Ueshima Eisuke, Okada Takuya, Sugimoto Koji, Murakami Takamichi
    (一社)日本インターベンショナルラジオロジー学会, May 2022, 日本インターベンショナルラジオロジー学会雑誌, 37(Suppl.) (Suppl.), 212 - 212, English

  • 光イメージングで視認可能な担癌ラットモデルの開発(第二報)
    高木 治行, 平田 豊, 上嶋 英介, 児玉 大志, 山門 亨一郎
    (一社)日本インターベンショナルラジオロジー学会, Mar. 2022, 日本インターベンショナルラジオロジー学会雑誌, 36(2) (2), 200 - 200, Japanese

  • EVAR後の内腸骨動脈瘤をup-and-over techniqueを用いてExcluder IBEで治療した1例
    佐々木 康二, 岡田 卓也, 山口 雅人, 松代 啓吾, 元津 倫幸, 上嶋 英介, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Mar. 2022, 日本インターベンショナルラジオロジー学会雑誌, 36(2) (2), 194 - 194, Japanese

  • 祖父江 慶太郎, 上嶋 英介, 上野 嘉子, 村上 卓道
    (株)Gakken, Mar. 2022, 画像診断, 42(4) (4), S106 - S119, Japanese

  • Keitaro Sofue, Eisuke Ueshima, Atsuhiro Masuda, Sachiyo Shirakawa, Yoh Zen, Yoshiko Ueno, Yushi Tsujita, Takeru Yamaguchi, Shinji Yabe, Takeshi Tanaka, Noriko Inomata, Hirochika Toyama, Takumi Fukumoto, Yuzo Kodama, Takamichi Murakami
    Mar. 2022, EUROPEAN RADIOLOGY, 32(3) (3), 1770 - 1780, English
    Scientific journal

  • 123I-MIBGシンチグラフィで腎に異常集積を認めた腎動脈解離の1例
    杉山 朋加, 辻田 有志, 神田 知紀, 山口 尊, 矢部 慎二, 上嶋 英介, 上野 嘉子, 河野 淳, 祖父江 慶太郎, 野上 宗伸, 堀 雅敏, 村上 卓道
    (公社)日本医学放射線学会, Feb. 2022, Japanese Journal of Radiology, 40(Suppl.) (Suppl.), 39 - 39, Japanese

  • 佐々木 康二, 上嶋 英介, 岡田 卓也, 山口 雅人, 杉本 幸司, 村上 卓道
    (株)日本メディカルセンター, Feb. 2022, 臨床消化器内科, 37(3) (3), 304 - 310, Japanese

  • Takeru Yamaguchi, Keitaro Sofue, Eisuke Ueshima, Yoshiko Ueno, Yushi Tsujita, Shinji Yabe, Sachiyo Shirakawa, Hirochika Toyama, Masatoshi Hori, Takumi Fukumoto, Takamichi Murakami
    Jan. 2022, JOURNAL OF MAGNETIC RESONANCE IMAGING, English
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Koji Sasaki, Takuya Okada, Masato Yamaguchi, Masashi Tajiri, Mostafa Ahmed, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Koji Sugimoto, Takamichi Murakami
    PURPOSE: The purpose is to investigate the major and minor complications of the pancreas after transcatheter arterial embolization (TAE) using n-butyl-2-cyanoacrylate (NBCA) for bleeding from pancreatic arteries. MATERIALS AND METHODS: Thirty-three patients who underwent TAE using NBCA for acute bleeding from pancreatic arteries and their parent arteries followed by contrast-enhanced computed tomography (CE-CT) were evaluated retrospectively. Complications and risk factors were assessed using Mann-Whitney U test or Fisher's exact test for the univariate analysis. Patients' characteristic, embolized artery, procedure details, and clinical outcomes were examined as possible risk factors. RESULTS: TAE was performed successfully in all patients. Minor pancreatic complications occurred in 10 patients (30%), including acute mild pancreatitis (n = 4) and focal lack of pancreatic parenchymal enhancement on CE-CT without pancreatitis (n = 6). No cases of major pancreatic complications, such as moderate/severe pancreatitis, were reported. Embolized artery was the only significant risk factor. The rate of complications per embolized artery were 15% (three out of 20 patients) in the arteries of the pancreatic head and 54% (seven out of 13 patients) in the arteries of pancreatic body and tail (p = 0.025). CONCLUSION: TAE using NBCA for acute bleeding from pancreatic arteries is efficacious and safe. Mild pancreatic complications were observed more frequently in case of embolization of the pancreatic body and tail region than the pancreatic head.
    Oct. 2021, Japanese journal of radiology, 40(3) (3), 308 - 317, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 上嶋 英介, 祖父江 慶太郎, 村上 卓道
    医学図書出版(株), Sep. 2021, 胆と膵, 42(9) (9), 815 - 822, Japanese

  • 保本 卓, 石川 雅基, 井上 政則, 小野澤 志郎, 作原 祐介, 佐藤 洋造, 高木 治行, 中塚 誠之, 中村 一彦, 藤原 寛康, 清水 淳市, 山上 卓士, 三村 秀文, 上嶋 英介, ウッドハムス 玲子, 大内 泰文, 我那覇 文清, 桑鶴 良平, 高良 真一, 小金丸 雅道, 駒田 智大, 米虫 敦, 塩山 靖和, 菅原 俊祐, 杉山 宗弘, 瀧川 政和, 徳江 浩之, 中村 恩, 西村 潤一, 野口 智幸, 橋爪 卓也, 橋本 政幸, 長谷部 光泉, 東浦 渉, 松浦 克彦, 松本 知博, 村上 優, 矢田 晋作, 山西 伴明, 日本IVR学会
    (一社)日本インターベンショナルラジオロジー学会, Sep. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(1) (1), 82 - 98, Japanese

  • 上嶋 英介, 祖父江 慶太郎, 村上 卓道
    医学図書出版(株), Sep. 2021, 胆と膵, 42(9) (9), 815 - 822, Japanese

  • 逆チャンス型胸椎骨折による血胸の一例
    松永 直樹, 岡田 卓也, 大野 雄康, 松代 啓吾, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, Aug. 2021, 日本医学放射線学会秋季臨床大会抄録集, 57回, S464 - S464, Japanese

  • ラットモデルにおける門脈塞栓術 無水エタノールとn-butyl-cyanoacrylateの比較
    丸山 光也, 高木 治行, 吉村 奈穂美, 木野田 直也, 上嶋 英介, 児玉 大志, 山田 直子, 北垣 一, 山門 亨一郎
    (一社)日本門脈圧亢進症学会, Aug. 2021, 日本門脈圧亢進症学会雑誌, 27(3) (3), 154 - 154, English

  • Mostafa Hamada, Eisuke Ueshima, Takeaki Ishihara, Yutaka Koide, Takuya Okada, Hiroki Horinouchi, Jun Ishida, Hiroshi Mayahara, Koji Sasaki, Tomoyuki Gentsu, Keitaro Sofue, Masato Yamaguchi, Ryohei Sasaki, Koji Sugimoto, Takamichi Murakami
    Background: Technological developments have led to an increased usage of external-body radiotherapy (RT) for the treatment of hepatocellular carcinoma (HCC). Transcatheter arterial chemoembolization (TACE) may be required later in patients treated with RT because of the high recurrence rate and multinodular presentation of HCC. However, despite the risk of liver function impairment, the cumulative liver damage correlated with TACE following a hepatic RT has not been adequately assessed. Purpose: To evaluate the feasibility of TACE following RT for HCC. Materials and methods: Sixty-seven patients with HCC who underwent TACE after RT were retrospectively evaluated between 2012 and 2018. We assessed increases in Child-Turcotte-Pugh (CTP) by ≥2 points at 1 month, the incidence of major complications, survival duration, and short-term mortality within 6 months after TACE. Furthermore, we evaluated the predictive factors for liver function impairment and short-term mortality. Results: Eight patients experienced a CTP increase ≥2 points at 1 month. There were no cases of liver abscesses or bilomas. Nine patients died within 6 months following TACE. The mean liver dose (MLD) was a significant predictor of liver function impairment at 1 month (p = 0.042). Low liver functional reserve, distant metastasis (p = 0.037), MLD (p = 0.046), TACE type (p = 0.025), and TACE within 3 months following RT (p = 0.007) were significant predictors of short-term mortality. Conclusions: Despite the feasibility of TACE following RT, clinicians should pay attention to impaired pretreatment liver function, following high dose RT, and the short duration between RT and TACE.
    Corresponding, Jul. 2021, Acta radiologica open, 10(7) (7), 20584601211034965 - 20584601211034965, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Koji Sasaki, Takuya Okada, Masato Yamaguchi, Mostafa Ahmed, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Kenji Tanimura, Hideto Yamada, Koji Sugimoto, Takamichi Murakami
    Jul. 2021, EMERGENCY RADIOLOGY, 28(6) (6), 1127 - 1133, English
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Masashi Fujimori, Yasushi Kimura, Eisuke Ueshima, Damian E. Dupuy, Prasad S. Adusumilli, Stephen B. Solomon, Govindarajan Srimathveeravalli
    Jun. 2021, BIOELECTRICITY, 3(3) (3), 204 - 214, English
    Scientific journal

  • Eisuke Ueshima, Keitaro Sofue, Takamichi Murakami
    Lead, Japan Society of Hepatology, May 2021, Kanzo, 62(5) (5), 229 - 239
    Scientific journal

  • 大動脈疾患に対するIVR治療の現況と課題 EVARの遠隔期成績向上への取り組み
    元津 倫幸, 山口 雅人, 佐々木 康二, Hamada Mostafa, 上嶋 英介, 岡田 卓也, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 125 - 125, Japanese

  • Shaggy aorta症例における上腸間膜動脈バルーンプロテクション併用下TEVARの有用性の検討
    佐々木 康二, 岡田 卓也, 山口 雅人, 田尻 昌士, Hamada Mostafa, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 160 - 160, Japanese

  • ウサギVX2腫瘍モデルを用いた過酸化チタンナノ粒子動注の基礎的研究
    岡田 卓也, 元津 倫幸, 西村 勇哉, 森田 健太, 上嶋 英介, 山口 雅人, 杉本 幸司, 佐々木 良平, 荻野 千秋, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 191 - 191, Japanese

  • 上顎癌動注化学療法における腫瘍進展方向と栄養血管に関する検討(Tumor extension and feeding arteries in intraarterial chemotherapy for maxillary cancer)
    Hamada Mostafa, 岡田 卓也, 山口 雅人, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 201 - 201, English

  • 陰部腟静脈瘤に対し血管内治療を行った1例
    田尻 昌士, 岡田 卓也, Ahmed Mostafa, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 251 - 251, Japanese

  • 門脈塞栓術後肝肥大 ラットモデルを用いた無水エタノールとn-butyl-cyanoacrylate glueの比較(Portal vein embolization: In vivo comparison of ethanol and n-butyl-cyanoacrylate in a rat model)
    丸山 光也, 高木 治行, 吉村 奈穂美, 木野田 直也, 上嶋 英介, 児玉 大志, 山田 直子, 平田 豊, 北垣 一, 山門 亨一郎
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 172 - 172, English

  • 微小肺病変に対する胸腔鏡補助下肺部分切除術においてCTガイド下マーキングが有用であった1例
    中谷 太一, 大片 祐一, 尾藤 祐子, 會田 洋輔, 宮内 玄徳, 冨岡 雄一郎, 中井 優美子, 谷 龍一郎, 上嶋 英介, 杉本 幸司
    (公社)日本小児科学会, Apr. 2021, 日本小児科学会雑誌, 125(4) (4), 674 - 674, Japanese

  • 祖父江 慶太郎, 上嶋 英介, 村上 卓道, 矢部 慎二, 辻田 有志, 山口 尊, 上野 嘉子, 堀 雅敏
    (株)メジカルビュー社, Apr. 2021, 臨床画像, 37(4) (4), 490 - 497, Japanese

  • Koji Maruyama, Takuya Okada, Takeshi Ueha, Kayako Isohashi, Hayato Ikeda, Yasukazu Kanai, Koji Sasaki, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Munenobu Nogami, Masato Yamaguchi, Koji Sugimoto, Yoshitada Sakai, Jun Hatazawa, Takamichi Murakami
    Mar. 2021, Oncology Letters, 21(3) (3), 207 - 207, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 【血管内治療における抗血栓療法】外傷性・医原性血管損傷に対するバイアバーン留置後の抗血栓療法
    岡田 卓也, 松代 啓吾, Hamada Mostafa, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本血管内治療学会, 2021, 日本血管内治療学会誌, 22(1) (1), 50 - 53, Japanese

  • 【血管内治療における抗血栓療法】外傷性・医原性血管損傷に対するバイアバーン留置後の抗血栓療法
    岡田 卓也, 松代 啓吾, Hamada Mostafa, 佐々木 康二, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本血管内治療学会, 2021, 日本血管内治療学会誌, 22(1) (1), 50 - 53, Japanese

  • Haruyuki Takaki, Yuki Kodama, Hisao Miyamoto, Yuto Iijima, Yoshinari Kikuchi, Hiroshi Kodama, Eisuke Ueshima, Keiji Nakasho, Reona Wada, Koichiro Yamakado
    Jan. 2021, CardioVascular and Interventional Radiology, 44(1) (1), 150 - 155, English, International magazine
    Scientific journal

  • Hiroki Horinouchi, Eisuke Ueshima, Keitaro Sofue, Shohei Komatsu, Takuya Okada, Masato Yamaguchi, Takumi Fukumoto, Koji Sugimoto, Takamichi Murakami
    BACKGROUND: Postoperative biliary strictures are commonly related to accidental bile duct injuries or occur at the site of biliary anastomosis. The first-line treatment for benign biliary strictures is endoscopic therapy, which is less invasive and repeatable. However, recanalization for biliary complete obstruction is technically challenging to treat. The present report describes a successful case of treatment by extraluminal recanalization for postoperative biliary obstruction using a transseptal needle. CASE PRESENTATION: A 66-year-old woman had undergone caudal lobectomy for the treatment of hepatocellular carcinoma. The posterior segmental branch of the bile duct was injured and repaired intraoperatively. Three months after the surgery, the patient had developed biliary leakage from the right hepatic bile duct, resulting in complete biliary obstruction. Since intraluminal recanalization with conventional endoscopic and percutaneous approaches with a guidewire failed, extraluminal recanalization using a transseptal needle with an internal lumen via percutaneous approach was performed under fluoroscopic guidance. The left lateral inferior segmental duct was punctured, and an 8-F transseptal sheath was introduced into the ostium of right hepatic duct. A transseptal needle was advanced, and the right hepatic duct was punctured by targeting an inflated balloon that was placed at the end of the obstructed right hepatic bile duct. After confirming successful puncture using contrast agent injected through the internal lumen of the needle, a 0.014-in. guidewire was advanced into the right hepatic duct. Finally, an 8.5-F internal-external biliary drainage tube was successfully placed without complications. One month after the procedure, the drainage tube was replaced with a 10.2-F drainage tube to dilate the created tract. Subsequent endoscopic internalization was performed 5 months after the procedure. At the 1-year follow-up examination, there was no sign of biliary obstruction and recurrence of hepatocellular carcinoma. CONCLUSIONS: Recanalization using a transseptal needle can be an alternative technique for rigid biliary obstruction when conventional techniques fail.
    Dec. 2020, Surgical case reports, 6(1) (1), 304 - 304, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 治療適応の基準を満たさない腎血管筋脂肪腫の破裂
    元津 倫幸, 山口 雅人, 佐々木 康二, Hamada M.A.S., 上嶋 英介, 岡田 卓也, 祖父江 慶太郎, 杉本 幸司, 村上 卓道
    (公社)日本医学放射線学会, Oct. 2020, 日本医学放射線学会秋季臨床大会抄録集, 56回, S144 - S144, Japanese

  • Yushi Tsujita, Keitaro Sofue, Shohei Komatsu, Takeru Yamaguchi, Eisuke Ueshima, Yoshiko Ueno, Tomonori Kanda, Takuya Okada, Munenobu Nogami, Masato Yamaguchi, Masakatsu Tsurusaki, Masatoshi Hori, Takumi Fukumoto, Takamichi Murakami
    Sep. 2020, European Journal of Radiology, 130
    Scientific journal

  • Haruyuki Takaki, Yutaka Hirata, Eisuke Ueshima, Hiroshi Kodama, Seiji Matsumoto, Reona Wada, Hitomi Suzuki, Keiji Nakasho, Koichiro Yamakado
    Sep. 2020, Journal of Vascular and Interventional Radiology, 31(9) (9), 1475 - 1482.e2, English, International magazine
    Scientific journal

  • 液体塞栓物質(NBCA)を極める! エキスパートへの道 膵領域の急性出血に対するNBCAを用いた動脈塞栓術の検討
    佐々木 康二, 岡田 卓也, 山口 雅人, Hamada Mostafa, 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Aug. 2020, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 122 - 122, Japanese

  • 骨転移疼痛に対する集学的治療 -この痛みをどう治療するか- 骨転移に対する骨セメント治療 経皮的椎体形成術の適応を考える
    岡田 卓也, 佐々木 康二, Hamada M.A.S., 元津 倫幸, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Aug. 2020, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 131 - 131, Japanese

  • 大動脈解離に対するIVR 大動脈解離に対するIVRの現況と課題
    山口 雅人, 岡田 卓也, 佐々木 康二, 元津 倫幸, 上嶋 英介, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Aug. 2020, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 133 - 133, Japanese

  • ドセタキセル含浸薬剤溶出性ビーズの基礎的検討
    谷 龍一郎, 岡田 卓也, 上嶋 英介, 篠原 正和, 元津 倫幸, 佐々木 康二, Hamada M.A.S, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Aug. 2020, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 282 - 282, Japanese

  • Yasutaka Yamada, Atsuhiro Masuda, Keitaro Sofue, Eisuke Ueshima, Hideyuki Shiomi, Arata Sakai, Takashi Kobayashi, Takuya Ikegawa, Shunta Tanaka, Ryota Nakano, Takeshi Tanaka, Maya Kakihara, Shigeto Ashina, Masahiro Tsujimae, Kohei Yamakawa, Shohei Abe, Masanori Gonda, Shigeto Masuda, Noriko Inomata, Hiromu Kutsumi, Tomoo Itoh, Takamichi Murakami, Yuzo Kodama
    Aug. 2020, JGH Open, 4(4) (4), 677 - 683
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 新生児マススクリーニングにて高ガラクトース血症を指摘された先天性門脈体循環シャントの1例
    中谷 太一, 大片 祐一, 尾藤 祐子, 會田 洋輔, 宮内 玄徳, 冨岡 雄一郎, 橘木 由美子, 中井 優美子, 上嶋 英介, 山口 雅人
    (公社)日本小児科学会, Jun. 2020, 日本小児科学会雑誌, 124(6) (6), 1038 - 1038, Japanese

  • Hiroki Horinouchi, Takuya Okada, Masato Yamaguchi, Koji Maruyama, Koji Sasaki, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Ryota Kawasaki, Yoshikatsu Nomura, Atsushi Omura, Kenji Okada, Koji Sugimoto, Takamichi Murakami
    May 2020, CardioVascular and Interventional Radiology, 43(5) (5), 696 - 705, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiroki Horinouchi, Keitaro Sofue, Tatsuya Nishii, Koji Maruyama, Koji Sasaki, Tomoyuki Gentsu, Eisuke Ueshima, Takuya Okada, Masato Yamaguchi, Koji Sugimoto, Takamichi Murakami
    May 2020, European Journal of Radiology, 126, 108861 - 108861, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Koji Maruyama, Keitaro Sofue, Hiroki Horinouchi, Takuya Okada, Eisuke Ueshima, Tomoyuki Gentsu, Koji Sasaki, Masato Yamaguchi, Koji Sugimoto, Takamichi Murakami
    Jan. 2020, Journal of computer assisted tomography, 44(1) (1), 153 - 159
    [Refereed]
    Scientific journal

  • Eisuke Ueshima, Hideyuki Nishiofuku, Haruyuki Takaki, Yutaka Hirata, Hiroshi Kodama, Toshihiro Tanaka, Kimihiko Kichikawa, Koichiro Yamakado, Takuya Okada, Keitaro Sofue, Masato Yamaguchi, Koji Sugimoto, Takamichi Murakami
    Lead, Jan. 2020, Liver Cancer, 9(1) (1), 63 - 72, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Masahiro Tsujimae, Atsuhiro Masuda, Hideyuki Shiomi, Hirochika Toyama, Keitaro Sofue, Eisuke Ueshima, Kohei Yamakawa, Shigeto Ashina, Yasutaka Yamada, Takeshi Tanaka, Shunta Tanaka, Ryota Nakano, Yu Sato, Takuya Ikegawa, Manabu Kurosawa, Seiji Fujigaki, Takashi Kobayashi, Arata Sakai, Hiromu Kutsumi, Yoh Zen, Tomoo Itoh, Takumi Fukumoto, Yuzo Kodama
    Sep. 2019, Journal of Gastroenterology and Hepatology (Australia), 34(9) (9), 1648 - 1655, English, International magazine
    [Refereed]
    Scientific journal

  • 細径ラジオ波電極針の開発と凝固範囲の検討
    高木 治行, 児玉 祐貴, 宮本 久生, 飯嶋 勇斗, 菊池 義成, 児玉 大志, 上嶋 英介, 山門 亨一郎
    (一社)日本インターベンショナルラジオロジー学会, Sep. 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(1) (1), 77 - 77, Japanese

  • Ueshima E, Fujimori M, Kodama H, Felsen D, Chen J, Durack JC, Solomon SB, Coleman JA, Srimathveeravalli G
    Jul. 2019, American journal of physiology. Renal physiology, 317(7) (7), F52 - F64, Co-authored internationally
    [Refereed]

  • H. Kodama, E. Ueshima, K. Howk, S. W. Lee, J. P. Erinjeri, S. B. Solomon, G. Srimathveeravalli
    May 2019, Diagnostic and Interventional Imaging, 100(5) (5), 279 - 285, English, Co-authored internationally
    [Refereed]
    Scientific journal

  • Ryuichiro Tani, Keitaro Sofue, Koji Sugimoto, Naoto Katayama, Mostafa A.S. Hamada, Koji Maruyama, Hiroki Horinouchi, Tomoyuki Gentsu, Koji Sasaki, Eisuke Ueshima, Yutaka Koide, Takuya Okada, Masato Yamaguchi, Takamichi Murakami
    Apr. 2019, Japanese Journal of Radiology, 37(4) (4), 328 - 335, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Tomoyuki Gentsu, Takuya Okada, Masato Yamaguchi, Hiroki Horinouchi, Naoto Katayama, Eisuke Ueshima, Yutaka Koide, Keitaro Sofue, Yasuko Gotake, Yoshikatsu Nomura, Hiroshi Tanaka, Yutaka Okita, Koji Sugimoto, Takamichi Murakami
    Apr. 2019, CardioVascular and Interventional Radiology, 42(4) (4), 505 - 512, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Koji Maruyama, Keitaro Sofue, Takuya Okada, Yutaka Koide, Eisuke Ueshima, Genzo Iguchi, Ryuichiro Tani, Tomoyuki Gentsu, Hiroki Horinouchi, Koji Sasaki, Masato Yamaguchi, Koji Sugimoto, Takamichi Murakami
    Apr. 2019, CardioVascular and Interventional Radiology, 42(4) (4), 542 - 551, English
    [Refereed]
    Scientific journal

  • Hiroshi Kodama, Eisuke Ueshima, Song Gao, Sebastien Monette, Lee Ronn Paluch, Kreg Howk, Joseph P. Erinjeri, Stephen B. Solomon, Govindarajan Srimathveeravalli
    Nov. 2018, International Journal of Hyperthermia, 34(8) (8), 1186 - 1193, Co-authored internationally
    Scientific journal

  • 光イメージングで視認可能な担癌ラットモデルの開発(第一報)
    高木 治行, 平田 豊, 上嶋 英介, 児玉 大志, 山門 亨一郎
    (一社)日本インターベンショナルラジオロジー学会, Nov. 2018, IVR: Interventional Radiology, 33(3) (3), 317 - 317, Japanese

  • Yangkui Gu, Govindarajan Srimathveeravalli, Liqun Cai, Eisuke Ueshima, Majid Maybody, Hooman Yarmohammadi, Yuan Shan Zhu, Jeremy C. Durack, Stephen B. Solomon, Jonathan A. Coleman, Joseph P. Erinjeri
    Jun. 2018, Cryobiology, 82, 106 - 111, English, Co-authored internationally
    [Refereed]
    Scientific journal

  • Eisuke Ueshima, Koji Sugimoto, Takuya Okada, Naoto Katayama, Yutaka Koide, Keitaro Sofue, Mayumi Morizane, Kenji Tanimura, Masashi Deguchi, Masato Yamaguchi
    Jun. 2018, Japanese Journal of Radiology, 36(6) (6), 394 - 400, English, Domestic magazine
    [Refereed]
    Scientific journal

  • 低酸素刺激が免疫抑制因子発現に与える影響について ラット肝細胞癌株による検討
    高木 治行, 平田 豊, 上嶋 英介, 谷口 純一, 加古 泰一, 小林 薫, 山門 亨一郎
    (一社)日本インターベンショナルラジオロジー学会, May 2018, IVR: Interventional Radiology, 33(1) (1), 66 - 66, Japanese

  • Hiroshi Kodama, Laurien G. Vroomen, Eisuke Ueshima, Jennifer Reilly, Whitney Brandt, Lee Ronn Paluch, Sebastien Monette, David Jones, Stephen B. Solomon, Govindarajan Srimathveeravalli
    May 2018, Journal of Thoracic and Cardiovascular Surgery, 155(5) (5), 2150 - 2159.e3, Co-authored internationally
    [Refereed]
    Scientific journal

  • 右副腎静脈を確認するための副腎静脈サンプリング中血管造影CTの有用性(The utility of Angio-CT during adrenal venous sampling to confirm the right adrenal vein)
    Maruyama Koji, Sofue Keitaro, Okada Takuya, Hamada Mostafa, Sasaki Koji, Horinouchi Hiroki, Gentsu Tomoyuki, Tani Ryuichiro, Ueshima Eisuke, Koide Yutaka, Yamaguchi Masato, Sugimoto Koji
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2018, IVR: Interventional Radiology, 33(Suppl.) (Suppl.), 190 - 190, English

  • 血管過多性脊髄腫瘍の部分切除のための術前塞栓術の実行可能性(The feasibility of preoperative embolization for partial resection of hypervascular spinal tumor)
    Tani Ryuichiro, Ueshima Eisuke, Hamada Mostafa, Sasaki Koji, Maruyama Koji, Horinouchi Hiroki, Gentsu Tomoyuki, Koide Yutaka, Okada Takuya, Sofue Keitaro, Kakutani Kenichiro, Yamaguchi Masato, Sugimoto Koji
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2018, IVR: Interventional Radiology, 33(Suppl.) (Suppl.), 191 - 191, English

  • 膵および膵周囲動脈の急性出血に対するNBCA塞栓術(Embolization with NBCA for acute bleeding of pancreatic and peripancreatic arteries)
    Sasaki Koji, Okada Takuya, Hamada Mostafa, Maruyama Koji, Horinouchi Hiroki, Gentsu Tomoyuki, Tani Ryuichiro, Ueshima Eisuke, Koide Yutaka, Sofue Keitaro, Yamaguchi Masato, Sugimoto Koji
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2018, IVR: Interventional Radiology, 33(Suppl.) (Suppl.), 227 - 227, English

  • 血管内腹部大動脈修復(EVAR)後のII型エンドリーク塞栓術の長期転帰(Long-term outcome of type II endoleak embolization after endovascular abdominal aortic repair (EVAR))
    Horinouchi Hiroki, Okada Takuya, Yamaguchi Masato, Sasaki Koji, Maruyama Koji, Gentsu Tomoyuki, Tani Ryuichiro, Ueshima Eisuke, Koide Yutaka, Kawasaki Ryota, Gotake Yasuko, Okita Yutaka, Sugimoto Koji
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2018, IVR: Interventional Radiology, 33(Suppl.) (Suppl.), 238 - 238, English

  • 下腸間膜動脈閉塞を伴うEVAR後の2型エンドリークの予測因子(Predictive factors of type 2 endoleaks after EVAR with occluded inferior mesenteric artery)
    Okada Takuya, Gentsu Tomoyuki, Yamaguchi Masato, Sasaki Koji, Maruyama Koji, Horinouchi Hiroki, Ueshima Eisuke, Koide Yutaka, Gotake Yasuko, Tanaka Hiroshi, Okita Yutaka, Sugimoto Koji
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2018, IVR: Interventional Radiology, 33(Suppl.) (Suppl.), 239 - 239, English

  • Kodama H, Ueshima E, Gao S, Monette S, Paluch LR, Howk K, Erinjeri JP, Solomon SB, Srimathveeravalli G
    Apr. 2018, Int J Hyperther, 18, 1 - 8, English, Co-authored internationally
    [Refereed]
    Scientific journal

  • Eisuke Ueshima, Mark Schattner, Robin Mendelsohn, Hans Gerdes, Sebastien Monette, Haruyuki Takaki, Jeremy C. Durack, Stephen B. Solomon, Govindarajan Srimathveeravalli
    Jan. 2018, Gastrointestinal Endoscopy, 87(1) (1), 300.e1 - 300.e6, English, Co-authored internationally
    [Refereed]
    Scientific journal

  • Eisuke Ueshima, Govindarajan Srimathveeravalli, Stephen B. Solomon
    Aug. 2017, Handbook of Electroporation, 1, 761 - 776, Co-authored internationally
    In book

  • Naoto Katayama, Koji Sugimoto, Takuya Okada, Takeshi Ueha, Yoshitada Sakai, Hideo Akiyoshi, Keiichiro Mie, Eisuke Ueshima, Keitaro Sofue, Yutaka Koide, Ryuichiro Tani, Tomoyuki Gentsu, Masato Yamaguchi
    Aug. 2017, International Journal of Oncology, 51(2) (2), 695 - 701, English, International magazine
    [Refereed]
    Scientific journal

  • Noriaki Sakamoto, Masato Yamaguchi, Keitaro Sofue, Akhmadu Muradi, Koji Idoguchi, Takuya Okada, Eisuke Ueshima, Koji Sugimoto
    Aug. 2014, Japanese Journal of Radiology, 32(8) (8), 487 - 490, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Akhmadu Muradi, Masato Yamaguchi, Takuya Okada, Yoshikatsu Nomura, Koji Idoguchi, Eisuke Ueshima, Noriaki Sakamoto, Ryota Kawasaki, Yutaka Okita, Koji Sugimoto
    Apr. 2014, CardioVascular and Interventional Radiology, 37(2) (2), 348 - 354, English, International magazine
    [Refereed]
    Scientific journal

  • Akhmadu Muradi, Masato Yamaguchi, Koji Idoguchi, Yoshikatsu Nomura, Takuya Okada, Noriaki Sakamoto, Eisuke Ueshima, Yutaka Okita, Koji Sugimoto
    Feb. 2014, Annals of Vascular Surgery, 28(2) (2), 490.e13 - 490.e16, English, International magazine
    [Refereed]
    Scientific journal

  • Eisuke Ueshima, Masato Yamaguchi, Takeshi Ueha, Akhmadu Muradi, Takuya Okada, Koji Idoguchi, Keitaro Sofue, Toshihiro Akisue, Masahiko Miwa, Masahiko Fujii, Koji Sugimoto
    2014, Journal of Vascular and Interventional Radiology, 25(3) (3), 469 - 476, English, International magazine
    [Refereed]
    Scientific journal

  • Eisuke Ueshima, Masato Yamaguchi, Akhmadu Muradi, Takuya Okada, Koji Idoguchi, Keitaro Sofue, Yoshikatsu Nomura, Yutaka Okita, Koji Sugimoto
    2014, Journal of Vascular and Interventional Radiology, 25(11) (11), 1809 - 1815, English, International magazine
    [Refereed]
    Scientific journal

  • 大動脈瘤に対するステントグラフト内挿術の適応拡大における問題点 IFU外症例に対するステントグラフト内挿術の治療成績
    Sugimoto Koji, 井戸口 孝二, 山口 雅人, 野村 佳克, 大北 裕
    (一社)日本外科学会, Mar. 2013, 日本外科学会雑誌, 114(臨増2) (臨増2), 737 - 737, Japanese
    Research society

  • Teruaki Okuno, Masato Yamaguchi, Takuya Okada, Takuya Takahashi, Noriaki Sakamoto, Eisuke Ueshima, Kazuro Sugimura, Koji Sugimoto
    May 2012, Journal of Vascular Surgery, 55(5) (5), 1410 - 1418, English, International magazine
    [Refereed]
    Scientific journal

  • Endovascular treatment for pulmonary thromboembolism and deep vein thrombosis
    Koji Sugimoto, M. Yamaguchi, T. Mori, T. Okuno, T. Ishihara, E. Ueshima, K. Sugimura, Y. Koide
    2008, Japanese Journal of Clinical Radiology, 53(8) (8), 977 - 986
    Scientific journal

■ MISC
  • Haruyuki Takaki, Eisuke Ueshima, Yutaka Hirata, Takashi Hisai, Kohta Toshimitsu, Ryosuke Taiji, Tetsuya Tachiiri, Reona Wada, Hiroshi Kodama, Hideki Kunichika, Kiyoyuki Minamiguchi, Hideyuki Nishiofuku, Toshihiro Tanaka, Koichiro Yamakado
    Jan. 2026, JOURNAL OF CLINICAL ONCOLOGY, 44(2_SUPPL) (2_SUPPL), 585 - 585, English
    Summary international conference

  • Imaging differences between small duct and large duct intrahepatic cholangiocarcinoma
    上嶋英介, 祖父江慶太郎, 村上卓道
    2025, 肝胆膵, 91(5) (5)

  • Advances in Artificial Intelligence in Diagnostic Radiology for the Application of Liver Diseases
    祖父江慶太郎, 上嶋英介, 山口尊, 上野嘉子, 坪山尚寛, 堀雅俊, 村上卓道
    2025, 肝臓クリニカルアップデート, 11(1) (1)

  • 急性下肢動脈閉塞症に対するIndigo systemの初期使用経験
    梅野晃弘, 佐々木康二, 山中智晴, 上月瞭平, 松代啓吾, 元津倫幸, 上嶋英介, 祖父江慶太郎, 山口雅人, 村上卓道
    2025, 日本血管内治療学会学術総会プログラム・抄録集, 31st

  • 肺RFA患者の血液中exosome由来のガン細胞増殖作用のあるmicroRNA
    平田豊, 高木治行, 和田玲緒名, 児玉大志, 上嶋英介, 齊藤寿郎, 山門亨一郎
    2024, 日本分子生物学会年会プログラム・要旨集(Web), 47th

  • IVR Support during Cesarean Section for Pregnancies Complicated by Placenta Accreta Spectrum Disorders at Kobe University Hospital
    佐々木康二, 岡田卓也, 山口雅人, 岡本雄太郎, 松代啓吾, 元津倫幸, 上嶋英介, 祖父江慶太郎, 杉本幸司, 村上卓道
    2024, 日本インターベンショナルラジオロジー学会雑誌(Web), 38(3) (3)

  • 武田 玲伊子, 野村 正, 上嶋 英介
    症例は50歳女性で、右耳介腫脹、そう痒感、出血を主訴とし、耳介動静脈奇形(AVM)と診断した。塞栓硬化療法を行った結果、病変の著明な縮小、三角窩から対耳輪の形態の著明な改善を得られた。術後3年6ヵ月現在、毛細血管拡張を認めるが再燃は認めない。
    克誠堂出版(株), Jan. 2024, 形成外科, 67(1) (1), 43 - 47, Japanese

  • Impact of Transarterial Embolization/Transarterial Chemoembolization on the Tumor Immune Microenvironment
    上嶋英介, 祖父江慶太郎, 村上卓道
    2023, 画像診断, 43(3) (3)

  • Evidence and Current Practice to Improve the Long-term Outcome of Endovascular Abdominal Aneurysm Repair
    元津倫幸, 山口雅人, 松代啓吾, 佐々木康二, 上嶋英介, 岡田卓也, 杉本幸司, 村上卓道, 中井秀和, 山中勝弘, 岡田健次, 川崎竜太
    2023, 日本インターベンショナルラジオロジー学会雑誌(Web), 37(1) (1)

  • Interventional Radiology for Acute Mesenteric Arterial Occlusion
    佐々木康二, 岡田卓也, 松永直樹, 松代啓吾, 元津倫幸, 上嶋英介, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    2023, 日本インターベンショナルラジオロジー学会雑誌(Web), 37(2) (2)

  • Technical Tips of NBCA Embolization for Pancreatic and Gastrointestinal Hemorrhage
    岡田卓也, 佐々木康二, 岡本雄太郎, 松代啓吾, 元津倫幸, 上嶋英介, 祖父江慶太郎, 山口雅人, 村上卓道
    2023, 日本インターベンショナルラジオロジー学会雑誌(Web), 38(1) (1)

  • 電気離脱式マイクロコイルによるtemporary anchoring techniqueを用いて塞栓を行った腹腔動脈瘤の一例
    佐々木康二, 山口雅人, 岡田卓也, 松代啓吾, 元津倫幸, 上嶋英介, 杉本幸司, 村上卓道
    2023, 日本血管内治療学会学術総会プログラム・抄録集, 29th

  • 山上 卓士, 矢田 晋作, 浅野 仁覚, 足立 憲, 石川 源, 泉 雄一郎, 上嶋 英介, 大内 泰文, 加藤 仁美, 桑鶴 良平, 駒田 智大, 杉山 宗弘, 清治 和将, 曽根 美雪, 谷川 昇, 東原 大樹, 松本 知博, 村上 優, 森田 賢, 阿部 壮一郎, 池田 秀次, 伊東 伸剛, 遠藤 雅之, 岡田 浩章, 小黒 草太, 小野 祐介, 片山 大輔, 河合 剛, 岸本 健太郎, 木村 慎太郎, 木村 廉, 小谷 美香, 坂本 篤彦, 下平 政史, 曽田 昌弘, 高杉 昌平, 田中 会秀, 棚橋 裕吉, 塚本 和充, 永井 啓介, 中村 純寿, 濱本 耕平, 本行 秀成, 松井 裕輔, 松永 望, 宮崎 将也, 山本 修一, 山本 貴浩, 勝盛 哲也, 木村 正, 鈴木 直, 掛田 伸吾, 小泉 淳, 蘆田 浩一, 石川 雅基, 石山 公一, ウッドハムス 玲子, 魚谷 健祐, 牛島 泰宏, 江頭 秀哲, 扇 尚弘, 大田 信一, 梶原 賢司, 粕谷 秀輔, 我那覇 文清, 元津 倫幸, 高良 真一, 小金丸 雅道, 米虫 敦, 佐藤 塁, 清水 勧一朗, 塚田 実郎, 土谷 飛鳥, 富田 康介, 中井 資貴, 中村 一彦, 野口 智幸, 橋田 和靖, 橋本 政幸, 伴野 辰雄, 東出 高至, 古市 欣也, 松井 洋, 三浦 剛史, 本橋 健司, 保本 卓, 山添 真治, 日本IVR学会, 症候性子宮筋腫に対する子宮動脈塞栓術(UAE)ガイドライン2021作成委員会, 日本IVR学会ガイドライン委員会
    (一社)日本インターベンショナルラジオロジー学会, Dec. 2022, 日本インターベンショナルラジオロジー学会雑誌, 36(4) (4), 365 - 401, Japanese

  • 山上 卓士, 矢田 晋作, 浅野 仁覚, 足立 憲, 石川 源, 泉 雄一郎, 上嶋 英介, 大内 泰文, 加藤 仁美, 桑鶴 良平, 駒田 智大, 杉山 宗弘, 清治 和将, 曽根 美雪, 谷川 昇, 東原 大樹, 松本 知博, 村上 優, 森田 賢, 阿部 壮一郎, 池田 秀次, 伊東 伸剛, 遠藤 雅之, 岡田 浩章, 小黒 草太, 小野 祐介, 片山 大輔, 河合 剛, 岸本 健太郎, 木村 慎太郎, 木村 廉, 小谷 美香, 坂本 篤彦, 下平 政史, 曽田 昌弘, 高杉 昌平, 田中 会秀, 棚橋 裕吉, 塚本 和充, 永井 啓介, 中村 純寿, 濱本 耕平, 本行 秀成, 松井 裕輔, 松永 望, 宮崎 将也, 山本 修一, 山本 貴浩, 勝盛 哲也, 木村 正, 鈴木 直, 掛田 伸吾, 小泉 淳, 蘆田 浩一, 石川 雅基, 石山 公一, ウッドハムス 玲子, 魚谷 健祐, 牛島 泰宏, 江頭 秀哲, 扇 尚弘, 大田 信一, 梶原 賢司, 粕谷 秀輔, 我那覇 文清, 元津 倫幸, 高良 真一, 小金丸 雅道, 米虫 敦, 佐藤 塁, 清水 勧一朗, 塚田 実郎, 土谷 飛鳥, 富田 康介, 中井 資貴, 中村 一彦, 野口 智幸, 橋田 和靖, 橋本 政幸, 伴野 辰雄, 東出 高至, 古市 欣也, 松井 洋, 三浦 剛史, 本橋 健司, 保本 卓, 山添 真治, 日本IVR学会, 症候性子宮筋腫に対する子宮動脈塞栓術(UAE)ガイドライン2021作成委員会, 日本IVR学会ガイドライン委員会
    (一社)日本インターベンショナルラジオロジー学会, Dec. 2022, 日本インターベンショナルラジオロジー学会雑誌, 36(4) (4), 365 - 401, Japanese

  • EVAR後の内腸骨動脈瘤をup-and-over techniqueを用いてExcluder IBEで治療した1例
    佐々木康二, 岡田卓也, 山口雅人, 松代啓吾, 元津倫幸, 上嶋英介, 杉本幸司, 村上卓道
    2022, 日本インターベンショナルラジオロジー学会雑誌(Web), 36(2) (2)

  • The Effect of TACE on the Tumor Microenvironment and the Synergistic Effect of TACE Combined with Molecular Target Agent and Immune Checkpoint Inhibitor
    上嶋英介, 祖父江慶太郎, 松代啓吾, 佐々木康二, 元津倫幸, 岡田卓也, 山口雅人, 杉本幸司, 村上卓道
    2022, 日本インターベンショナルラジオロジー学会雑誌(Web), 36(3) (3)

  • 光イメージングで視認可能な担癌ラットモデルの開発:第二報
    高木治行, 平田豊, 上嶋英介, 児玉大志, 山門亨一郎
    2022, 日本インターベンショナルラジオロジー学会雑誌(Web), 36(2) (2)

  • 野口 智幸, 上嶋 英介, 米虫 敦, 菅原 俊祐, 西尾 美佐子, 原口 貴史, 廣石 篤司, 三村 秀文, 伊藤 千尋, 内山 史也, 馬越 紀行, 大西 康之, 加古 泰一, 片山 直人, 木村 慎太郎, 児玉 大志, 坂本 憲昭, 谷 龍一郎, 富松 浩隆, 中村 由香里, 長谷川 哲也, 藤塚 進司, 浅山 良樹, 小林 信雄, 大瀬戸 清茂, 里見 絵理子, 山上 卓士, 石川 雅基, ウッドハムス 玲子, 大内 泰文, 我那覇 文清, 桑鶴 良平, 高良 真一, 小金丸 雅道, 駒田 智大, 作原 祐介, 塩山 靖和, 杉山 宗弘, 瀧川 政和, 徳江 浩之, 中村 一彦, 中村 恩, 西村 潤一, 橋爪 卓也, 橋本 政幸, 長谷部 光泉, 東浦 渉, 松浦 克彦, 松本 知博, 村上 優, 保本 卓, 矢田 晋作, 山西 伴明, 脊椎転移の経皮的椎体形成術(PVP)ガイドライン作成委員会, 日本IVR学会ガイドライン委員会
    (一社)日本インターベンショナルラジオロジー学会, Feb. 2021, 日本インターベンショナルラジオロジー学会雑誌, 35(3) (3), 290 - 309, Japanese

  • ラットモデルにおける門脈塞栓術(無水エタノールとn-butyl-cyanoacrylateの比較)
    丸山光也, 丸山光也, 高木治行, 吉村奈穂美, 木野田直也, 上嶋英介, 児玉大志, 山田直子, 北垣一, 山門亨一郎
    2021, 日本門脈圧亢進症学会雑誌, 27(3) (3)

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    (一社)日本脈管学会, Oct. 2019, 脈管学, 59(Suppl.) (Suppl.), S140 - S140, Japanese

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    (一社)日本脈管学会, Oct. 2019, 脈管学, 59(Suppl.) (Suppl.), S175 - S175, Japanese

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    元津 倫幸, 岡田 卓也, 小出 裕, 佐々木 康二, Hamada M.A.S, 堀之内 宏樹, 谷 龍一郎, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Sep. 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(1) (1), 79 - 79, Japanese

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    (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 226 - 226, Japanese

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    佐々木 康二, 岡田 卓也, HAMADA MOSTAFA, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 239 - 239, Japanese

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    (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 255 - 255, Japanese

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    (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 259 - 259, Japanese

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    谷 龍一郎, 岡田 卓也, 佐々木 康二, HAMADA MOSTAFA, 堀之内 宏樹, 元津 倫幸, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 314 - 314, Japanese

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    (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 226 - 226, Japanese

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    高木治行, 児玉祐貴, 宮本久生, 飯嶋勇斗, 菊池義成, 児玉大志, 上嶋英介, 山門亨一郎
    2019, 日本インターベンショナルラジオロジー学会雑誌(Web), 34(1) (1)

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    2019, 脈管学(Web), 59(supplement) (supplement)

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    2019, 日本インターベンショナルラジオロジー学会雑誌(Web), 34(1) (1)

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    (一社)日本インターベンショナルラジオロジー学会, Nov. 2018, IVR: Interventional Radiology, 33(3) (3), 317 - 317, Japanese

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    小出 裕, 岡田 卓也, 佐々木 康二, 元津 倫幸, Hamada M.A.S, 谷 龍一郎, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Nov. 2018, IVR: Interventional Radiology, 33(3) (3), 317 - 318, Japanese

  • 中長期成績からみた腹部大動脈瘤ステントグラフトの功罪 IMA閉塞例におけるEVAR後のType 2エンドリークの検討 予防的IMA塞栓術は有用か?
    岡田 卓也, 元津 倫幸, 山口 雅人, 佐々木 康二, Hamada Mostafa, 谷 龍一郎, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 杉本 幸司, 村上 卓道, 後竹 康子, 中井 秀和, 山中 勝弘, 田中 裕史
    (一社)日本脈管学会, Sep. 2018, 脈管学, 58(Suppl.) (Suppl.), S107 - S107, Japanese

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    (一社)日本インターベンショナルラジオロジー学会, May 2018, IVR: Interventional Radiology, 33(1) (1), 66 - 66, Japanese

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    岡田卓也, 元津倫幸, 山口雅人, 佐々木康二, HAMADA Mostafa, 谷龍一郎, 上嶋英介, 小出裕, 祖父江慶太郎, 杉本幸司, 村上卓道, 後竹康子, 中井秀和, 山中勝弘, 田中裕史
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    (一社)日本脈管学会, Oct. 2017, 脈管学, 57(Suppl.) (Suppl.), S109 - S109, Japanese

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    Jul. 2017, Metallic Stentの現状と進歩XVII, 32, 20 - 21, Japanese
    [Invited]
    Report scientific journal

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    (一社)日本インターベンショナルラジオロジー学会, Apr. 2017, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 164 - 164, Japanese

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    (一社)日本インターベンショナルラジオロジー学会, Apr. 2017, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 180 - 180, Japanese

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    (一社)日本インターベンショナルラジオロジー学会, Apr. 2017, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 236 - 236, Japanese

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    (一社)日本インターベンショナルラジオロジー学会, Apr. 2017, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 243 - 243, Japanese

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    丸山 晃司, 山口 雅人, 岡田 卓也, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 英介, 小出 裕, 杉本 幸司, 後竹 康子, 野村 佳克, 大北 裕
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2017, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 244 - 244, Japanese

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    (一社)日本インターベンショナルラジオロジー学会, Apr. 2017, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 246 - 246, Japanese

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    元津 倫幸, 岡田 卓也, 丸山 晃司, 堀之内 宏樹, 臼井 亮介, 片山 直人, 後竹 康子, 谷 龍一郎, 上嶋 英介, 小出 裕, 野村 佳克, 祖父江 慶太郎, 山口 雅人, 大北 裕, 杉本 幸司
    (一社)日本脈管学会, Oct. 2016, 脈管学, 56(Suppl.) (Suppl.), S137 - S137, Japanese

  • EndurantステントグラフトによるEVARの中長期成績
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    (一社)日本脈管学会, Oct. 2016, 脈管学, 56(Suppl.) (Suppl.), S167 - S167, Japanese

  • 左総腸骨動脈閉塞を伴う腹部大動脈瘤に対するEVAR後にTypell endoleak塞栓を繰り返した1例
    堀之内 宏樹, 山口 雅人, 丸山 晃司, 臼井 亮介, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 英介, 小出 裕, 岡田 卓也, 祖父江 慶太郎, 後竹 康子, 野村 佳克, 大北 裕, 杉本 幸司
    (一社)日本脈管学会, Oct. 2016, 脈管学, 56(Suppl.) (Suppl.), S188 - S189, Japanese

  • EVAR後の遅発性Type 1a endoleakに対し瘤内塞栓術およびAortic cuff留置術にて治療した1例
    丸山 晃司, 山口 雅人, 堀之内 宏樹, 谷 龍一郎, 元津 倫幸, 片山 直人, 小出 裕, 上嶋 英介, 岡田 卓也, 杉本 幸司, 野村 佳克, 後竹 康子, 大北 裕
    (一社)日本脈管学会, Oct. 2016, 脈管学, 56(Suppl.) (Suppl.), S189 - S189, Japanese

  • 上腸間膜動脈急性閉塞に対しフォガティースルールーメンカテーテルを用いて血栓除去を行った一例
    谷 龍一郎, 山口 雅人, 臼井 亮介, 丸山 晃司, 堀之内 宏樹, 元津 倫幸, 片山 直人, 上嶋 英介, 小出 裕, 岡田 卓也, 祖父江 慶太郎, 杉本 幸司, 野村 佳克, 後竹 康子, 大北 裕
    (一社)日本脈管学会, Oct. 2016, 脈管学, 56(Suppl.) (Suppl.), S207 - S207, Japanese

  • ハイブリッド手術システムを用いたIVR 非大血管疾患における臨床応用
    岡田 卓也, 山口 雅人, 臼井 亮介, 丸山 晃司, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 杉本 幸司
    (一社)日本インターベンショナルラジオロジー学会, Aug. 2016, IVR: Interventional Radiology, 31(3) (3), 266 - 266, Japanese

  • 左総腸骨動脈閉塞を伴う腹部大動脈瘤に対するEVAR後にType II endoleak塞栓を繰り返した1例
    堀之内 宏樹, 山口 雅人, 丸山 晃司, 臼井 亮介, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 英介, 小出 裕, 岡田 卓也, 祖父江 慶太郎, 杉本 幸司, 後竹 康子, 野村 佳克, 大北 裕
    (一社)日本インターベンショナルラジオロジー学会, Aug. 2016, IVR: Interventional Radiology, 31(3) (3), 267 - 267, Japanese

  • 予防的IMA塞栓術を施行したENDURANT Stentgraft Systemを用いたEVARの治療成績
    片山 直人, 岡田 卓也, 元津 倫幸, 谷 龍一郎, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 後竹 康子, 野村 佳克, 大北 裕
    (一社)日本インターベンショナルラジオロジー学会, Jun. 2016, IVR: Interventional Radiology, 31(2) (2), 178 - 178, Japanese

  • EVAR後の遅発性Type 1a endoleakに対し瘤内塞栓術およびAortic cuff留置術にて治療した1例
    小出 裕, 岡田 卓也, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 英介, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 後竹 康子, 野村 佳克, 大北 裕
    (一社)日本インターベンショナルラジオロジー学会, Jun. 2016, IVR: Interventional Radiology, 31(2) (2), 178 - 178, Japanese

  • 大動脈・末梢動脈疾患に対する救急IVR 神戸大学病院における取り組みとその応用
    山口 雅人, 元津 倫幸, 谷 龍一郎, 片山 直人, 上嶋 英介, 小出 裕, 岡田 卓也, 祖父江 慶太郎, 杉本 幸司, 後竹 康子, 野村 佳克, 大北 裕
    (一社)日本インターベンショナルラジオロジー学会, Jun. 2016, IVR: Interventional Radiology, 31(2) (2), 189 - 189, Japanese

  • TAEとデノスマブ投与の併用が奏功した仙骨巨細胞腫の1例
    谷 龍一郎, 岡田 卓也, 元津 倫幸, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司, 河本 旭哉
    (一社)日本インターベンショナルラジオロジー学会, Jun. 2016, IVR: Interventional Radiology, 31(2) (2), 182 - 182, Japanese

  • 【ハイブリッド手術室システムの応用-外科手術とIVRのコラボレーション-】 ハイブリッド手術室システムの臨床応用 神戸大学病院における大血管以外多領域での臨床応用の取り組み
    Yamaguchi Masato, Okada Takuya, 上嶋英介, Sofue Keitaro, 小出裕, 片山直人, 元津倫幸, 谷龍一郎, Sugimoto Koji
    (一社)日本インターベンショナルラジオロジー学会, Jun. 2016, IVR: Interventional Radiology, 31(2) (2), 129 - 135, Japanese
    [Refereed][Invited]
    Introduction scientific journal

  • ビーズ導入後のTACEの現状 多発肝細胞癌に対する非選択的DEB-TACEの有用性の検討
    岡田 卓也, 谷 龍一郎, 元津 倫幸, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2016, IVR: Interventional Radiology, 31(Suppl.) (Suppl.), 113 - 113, Japanese

  • EVAR後のDistal sealing zoneの形態変化と遅発性type 1bエンドリークの危険因子に関する検討
    元津 倫幸, 岡田 卓也, 谷 龍一郎, 片山 直人, 上嶋 英介, 小出 裕, 山口 雅人, 杉本 幸司, 後竹 康子, 野村 佳克, 大北 裕
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2016, IVR: Interventional Radiology, 31(Suppl.) (Suppl.), 131 - 131, Japanese

  • EndurantステントグラフトによるEVARの中長期成績
    小出 裕, 山口 雅人, 谷 龍一郎, 元津 倫幸, 片山 直人, 上嶋 英介, 岡田 卓也, 杉本 幸司, 野村 佳克, 後竹 康子, 大北 裕
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2016, IVR: Interventional Radiology, 31(Suppl.) (Suppl.), 135 - 135, Japanese

  • Endurantステントグラフトを用いたEVARにおける予防的IMA塞栓群・非塞栓群の比較・検討
    片山 直人, 山口 雅人, 元津 倫幸, 谷 龍一郎, 上嶋 英介, 小出 裕, 岡田 卓也, 杉本 幸司, 後竹 康子, 野村 佳克, 大北 裕
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2016, IVR: Interventional Radiology, 31(Suppl.) (Suppl.), 136 - 136, Japanese

  • ブタ肝後面下大静脈損傷モデルを用いたステントグラフトによる止血効果の検討
    井戸口 孝二, 山口 雅人, 片山 直人, 岡田 卓也, 上嶋 英介, 祖父江 慶太郎, 井芹 俊恵, 林 聡恵, 三重 慧一郎, 水島 靖明, 杉本 幸司
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2016, IVR: Interventional Radiology, 31(Suppl.) (Suppl.), 174 - 174, Japanese

  • 腎部分切除術後に腎動脈 腎杯瘻を来しTAEにて治療し得た1例
    片山 直人, 岡田 卓也, Akhmadu Muradi, 上嶋 英介, 小出 裕, 山口 雅人, 杉本 幸司
    (公社)日本医学放射線学会, Feb. 2016, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 53 - 53, Japanese

  • EVAR後の遅発性Type1a endoleakに対し瘤内塞栓術およびAortic cuff留置術にて治療した1例
    丸山晃司, 山口雅人, 堀之内宏樹, 谷龍一郎, 元津倫幸, 片山直人, 小出裕, 上嶋英介, 岡田卓也, 杉本幸司, 野村佳克, 後竹康子, 大北裕
    2016, 脈管学(Web), 56(supplement) (supplement), S189(J‐STAGE), Japanese

  • 左総腸骨動脈閉塞を伴う腹部大動脈瘤に対するEVAR後にTypeII endoleak塞栓を繰り返した1例
    堀之内宏樹, 山口雅人, 丸山晃司, 臼井亮介, 元津倫幸, 谷龍一郎, 片山直人, 上嶋英介, 小出裕, 岡田卓也, 祖父江慶太郎, 後竹康子, 野村佳克, 大北裕, 杉本幸司
    2016, 脈管学(Web), 56(supplement) (supplement), S188‐S189(J‐STAGE), Japanese

  • EndurantステントグラフトによるEVARの中長期成績
    小出裕, 山口雅人, 谷龍一郎, 丸山晃司, 元津倫幸, 堀之内宏樹, 片山直人, 上嶋英介, 岡田卓也, 杉本幸司, 野村佳克, 後竹康子, 大北裕
    2016, 脈管学(Web), 56(supplement) (supplement), S167(J‐STAGE), Japanese

  • EVAR後の遅発性type1bエンドリークの危険因子に関する検討
    元津倫幸, 岡田卓也, 丸山晃司, 堀之内宏樹, 臼井亮介, 片山直人, 後竹康子, 谷龍一郎, 上嶋英介, 小出裕, 野村佳克, 祖父江慶太郎, 山口雅人, 大北裕, 杉本幸司
    2016, 脈管学(Web), 56(supplement) (supplement), S137(J‐STAGE), Japanese

  • 上腸間膜動脈急性閉塞に対しフォガティースルールーメンカテーテルを用いて血栓除去を行った一例
    谷龍一郎, 山口雅人, 臼井亮介, 丸山晃司, 堀之内宏樹, 元津倫幸, 片山直人, 上嶋英介, 小出裕, 岡田卓也, 祖父江慶太郎, 杉本幸司, 野村佳克, 後竹康子, 大北裕
    2016, 脈管学(Web), 56(supplement) (supplement), S207(J‐STAGE), Japanese

  • 予防的IMA塞栓術を併施したENDURANT Stentgraft Systemを用いたEVARの治療成績
    片山 直人, 岡田 卓也, 後竹 康子, 上嶋 英介, 野村 佳克, 山口 雅人, 大北 裕, 杉本 幸司
    (一社)日本脈管学会, Oct. 2015, 脈管学, 55(Suppl.) (Suppl.), S131 - S131, Japanese

  • 当院における薬剤溶出性球状塞栓物質を用いたTACE(DEB-TACE)の初期治療成績
    片山 直人, 岡田 卓也, Muradi Akhmadu, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 山口 雅人, 杉本 幸司
    (一社)日本インターベンショナルラジオロジー学会, Sep. 2015, IVR: Interventional Radiology, 30(3) (3), 275 - 275, Japanese

  • 前下膵十二指腸動脈瘤破裂により十二指腸水平脚に高度狭窄を来たした1例
    小出 裕, 岡田 卓也, Muradi Akhmadu, 片山 直人, 上嶋 英介, 山口 雅人, 杉本 幸司
    (一社)日本インターベンショナルラジオロジー学会, Sep. 2015, IVR: Interventional Radiology, 30(3) (3), 277 - 277, Japanese

  • 前置・癒着胎盤の帝王切開時におけるIVR ハイブリッド手術室を利用した新たな治療戦略
    元津 倫幸, 岡田 卓也, 谷 龍一郎, 片山 直人, 上嶋 英介, 小出 裕, 山口 雅人, 杉本 幸司
    (一社)日本インターベンショナルラジオロジー学会, Sep. 2015, IVR: Interventional Radiology, 30(3) (3), 284 - 284, Japanese

  • 異時性に発症した両側特発性腸骨動脈解離の1例
    谷 龍一郎, 上嶋 英介, 元津 倫幸, 片山 直人, 小出 裕, 岡田 卓也, 山口 雅人, 野村 佳克, 大北 裕, 杉本 幸司
    (一社)日本インターベンショナルラジオロジー学会, Sep. 2015, IVR: Interventional Radiology, 30(3) (3), 286 - 286, Japanese

  • 門脈圧亢進症 PTO、TIOなど
    Okada Takuya, Yamaguchi Masato, 片山直人, MuradiAkhmadu, 上嶋英介, 小出裕, Sofue Keitaro, Sugimoto Koji
    (一社)日本インターベンショナルラジオロジー学会, Jun. 2015, IVR: Interventional Radiology, 30(2) (2), 166 - 171, Japanese
    [Refereed]
    Introduction scientific journal

  • 内腸骨動脈空置瘤に対して経動脈的塞栓術を施行した2例
    小出 裕, 岡田 卓也, Muradi Akhamadu, 片山 直人, 上嶋 英介, 山口 雅人, 杉本 幸司, 野村 佳克, 大北 裕
    (一社)日本インターベンショナルラジオロジー学会, Dec. 2014, IVR: Interventional Radiology, 29(4) (4), 435 - 435, Japanese

  • 【腹部Interventional Radiologyの手技とコツ】 腹部外傷に対するIVR
    Sugimoto Koji, 上嶋 英介, 片山 直人, Okada Takuya, 小出 裕, 祖父江 慶太郎, 井戸口 孝二, Yamaguchi Masato
    産業開発機構(株), Aug. 2014, 映像情報Medical, 46(8) (8), 732 - 737, Japanese
    [Invited]
    Introduction commerce magazine

  • 【NBCA塞栓術の現状と病理組織学的影響】 NBCA塞栓術の現状と病理組織学的影響 膵臓
    Okada Takuya, Yamaguchi Masato, Muradi Akhmadu, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, Sugimoto Koji
    (一社)日本インターベンショナルラジオロジー学会, Aug. 2014, IVR: Interventional Radiology, 29(3) (3), 252 - 257, Japanese
    [Invited]
    Introduction scientific journal

  • 巨細胞動脈炎の関与が疑われる両側上腕動脈病変に対しPTAを施行した2例
    上嶋 英介, 山口 雅人, 井戸口 孝二, 祖父江 慶太郎, 岡田 卓也, 片山 直人, Muradi Akhmadu, 杉本 幸司
    (一社)日本インターベンショナルラジオロジー学会, Jun. 2014, IVR: Interventional Radiology, 29(2) (2), 219 - 219, Japanese

  • 当院における非外傷性特発性後腹膜出血に対する動脈塞栓術の検討
    片山 直人, 祖父江 慶太郎, Muradi Akhmadu, 上嶋 英介, 岡田 卓也, 井戸口 孝二, 山口 雅人, 杉本 幸司
    (一社)日本インターベンショナルラジオロジー学会, Jun. 2014, IVR: Interventional Radiology, 29(2) (2), 223 - 223, Japanese

  • 外傷IVRの基本と応用 脾損傷
    井戸口 孝二, Yamaguchi Masato, 祖父江 慶太郎, Okada Takuya, 上嶋 英介, 片山 直人, 小出 裕, Muradi Akhmadu, Sugimoto Koji
    (一社)日本インターベンショナルラジオロジー学会, Jun. 2014, IVR: Interventional Radiology, 29(2) (2), 188 - 194, Japanese
    [Invited]
    Introduction scientific journal

  • 【非外傷性出血のIVR】 非外傷性の特発性後腹膜出血
    祖父江 慶太郎, Yamaguchi Masato, 片山 直人, Muradi Akhmadu, 上嶋 英介, 小出 裕, Okada Takuya, 井戸口 孝二, Sugimoto Koji
    (一社)日本インターベンショナルラジオロジー学会, Jun. 2014, IVR: Interventional Radiology, 29(2) (2), 140 - 146, Japanese
    [Invited]
    Introduction scientific journal

  • 周産期出血に対する子宮動脈塞栓術における子宮動脈造影所見の検討
    岡田 卓也, 山口 雅人, 上嶋 英介, Muradi Akhmadu, 片山 直人, 祖父江 慶太郎, 井戸口 孝二, 杉本 幸司
    (一社)日本インターベンショナルラジオロジー学会, May 2014, IVR: Interventional Radiology, 29(Suppl.) (Suppl.), 153 - 153, Japanese

  • 鈍的胸部大動脈損傷に対する企業性ステントグラフトを用いたTEVARの現状
    井戸口 孝二, 山口 雅人, 岡田 卓也, 上嶋 英介, 祖父江 慶太郎, 片山 直人, 小出 裕, Muradi Akhmadu, 杉本 幸司, 野村 佳克, 大北 裕, 森 岳樹
    (一社)日本インターベンショナルラジオロジー学会, May 2014, IVR: Interventional Radiology, 29(Suppl.) (Suppl.), 176 - 176, Japanese

  • 急性下肢動脈閉塞に対するFogarty Thru-Lumen catheterを用いた選択的血栓除去術の治療成績の検討
    片山 直人, 山口 雅人, 岡田 卓也, Muradi Akhmadu, 上嶋 英介, 野村 佳克, 祖父江 慶太郎, 井戸口 孝二, 大北 裕, 杉本 幸司
    (一社)日本インターベンショナルラジオロジー学会, May 2014, IVR: Interventional Radiology, 29(Suppl.) (Suppl.), 194 - 194, Japanese

  • EVAR後Type II Endoleak残存症例に対する追加治療の成績
    上嶋 英介, 山口 雅人, 井戸口 孝二, 祖父江 慶太郎, 岡田 卓也, 片山 直人, Muradi Akhmadu, 森 岳樹, 杉本 幸司
    (一社)日本インターベンショナルラジオロジー学会, May 2014, IVR: Interventional Radiology, 29(Suppl.) (Suppl.), 204 - 204, Japanese

  • 【救急疾患に対するIVR】 泌尿器科領域の救急疾患に対するIVR
    Okada Takuya, Yamaguchi Masato, Muradi Akhmadu, 片山 直人, 上嶋 英介, 祖父江 慶太郎, 井戸口 孝二, Sugimoto Koji
    (一社)日本インターベンショナルラジオロジー学会, Feb. 2014, IVR: Interventional Radiology, 29(1) (1), 34 - 42, Japanese
    [Invited]
    Introduction scientific journal

  • 内臓動脈瘤に対するIVR 孤立性内腸骨動脈瘤に対する血管内治療の長期成績
    山口 雅人, Muradi Akhmadu, 井戸口 孝二, 祖父江 慶太郎, 岡田 卓也, 上嶋 英介, 野村 佳克, 川崎 竜太, 大北 裕, 杉本 幸司
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2013, IVR: Interventional Radiology, 28(Suppl.) (Suppl.), 103 - 103, Japanese

  • 出血に対するIVR 非外傷性特発性後腹膜出血に対する動脈塞栓術の検討
    祖父江 慶太郎, 山口 雅人, Muradi Akhmadu, 井戸口 孝二, 坂本 憲昭, 奥野 晃章, 岡田 卓也, 上嶋 英介, 杉本 幸司
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2013, IVR: Interventional Radiology, 28(Suppl.) (Suppl.), 105 - 105, Japanese

  • 当院における危機的産科出血に対する子宮動脈塞栓術の治療成績
    奥野 晃章, 山口 雅人, 岡田 卓也, 井戸口 孝二, 坂本 憲昭, 祖父江 慶太郎, 上嶋 英介, 杉本 幸司
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2013, IVR: Interventional Radiology, 28(Suppl.) (Suppl.), 173 - 173, Japanese

  • 透析バスキュラーアクセス 透析シャント機能不全に対するIVR その適応と限界 閉塞例を中心に
    杉本 幸司, 森 岳樹, 山口 雅人, 奥野 晃章, 木下 めぐ美, 上嶋 英介
    (一社)日本インターベンショナルラジオロジー学会, May 2011, IVR: Interventional Radiology, 26(2) (2), 221 - 225, Japanese

  • 主経路慢性閉塞を伴う透析シャント不全に対するPTAの治療成績
    上嶋 英介, 森 岳樹, 山口 雅人, 石原 武明, 小出 裕, 奥野 晃彰, 杉本 幸司
    (公社)日本医学放射線学会, Feb. 2009, 日本医学放射線学会学術集会抄録集, 68回, S351 - S351, Japanese

  • 下横隔動脈が関与していた外傷性血胸の1例
    上嶋 英介, 森 岳樹, 奥野 晃彰, 石原 武明, 杉本 幸司, 小出 裕
    (公社)日本医学放射線学会, Sep. 2008, 日本医学放射線学会秋季臨床大会抄録集, 44回, S521 - S521, Japanese

  • 【肺血栓塞栓症のIVR治療に必要な画像診断とテクニック】肺血栓塞栓症と深部静脈血栓症のIVR治療
    杉本 幸司, 山口 雅人, 森 岳樹, 奥野 晃章, 石原 武明, 上嶋 英介, 小出 裕, 杉村 和朗
    金原出版(株), Aug. 2008, 臨床放射線, 53(8) (8), 977 - 986, Japanese

■ Books And Other Publications
  • Handbook of Electroporation / Medical Imaging of Electroporation
    Ueshima Eisuke, GovindarajanSrimathveeravalli, ndStephenBSolomon
    Others, Springer, 2017, English
    Scholarly book

■ Lectures, oral presentations, etc.
  • Optimizing Immunotherapy
    APPLE2025, Jul. 2025
    [Invited]

  • 術前門脈塞栓
    第60回 日本医学放射線学会 秋季臨床大会, Oct. 2024
    [Invited]

  • LEN-TACEの役割 〜放射線科の立場から〜
    日本消化器病学会近畿支部第120回 アフタヌーンセミナー, Jan. 2024
    [Invited]

  • 肝細胞癌の画像診断とカテーテル治療 〜最近の知見を踏まえて〜
    第10回 兵庫県放射線セミナー, Oct. 2023
    [Invited]

  • 免疫療法時代のIVR基礎研究と画像診断
    SAMI2023, Jul. 2023
    [Invited]

  • 肝動脈塞栓療法（TACE）による癌微小環境の変化
    第39回日本DDS学会学術集会, Jul. 2023
    [Invited]

  • 複合免疫治療時代の肝細胞癌 画像診断・IVRの役割
    第29回 先端医用画像研究会, Jul. 2023
    [Invited]

  • Lenvatinibが塞栓術後の癌微小環境中の免疫状態に与える影響~Rat肝癌モデルによる検討~
    第48回 播淡画像研究会, Jun. 2023
    [Invited]

  • Lenvatinibが塞栓術後の癌微小環境中の免疫状態に与える影響~Rat肝癌モデルによる検討~
    肝類洞壁細胞研究会, Dec. 2022
    [Invited]

  • TACEが癌微小環境に与える影響
    第44回播但画像診断研究会, Jun. 2021
    [Invited]

  • 肝悪性腫瘍の画像診断
    上嶋英介
    第219回 関西アンギオIVRカンファレンス, Feb. 2020, Japanese
    [Invited]
    Public discourse

  • Lenvatinib+TACEの有用性 〜基礎的研究の観点から〜
    上嶋英介
    IVR Expert Meeting, Jan. 2020, Japanese
    [Invited]
    Public discourse

  • IVRと癌微小環境
    Eisuke UESHIMA
    第22回 大阪神戸腹部画像診断・IVR医学研究会, Dec. 2019, Japanese, Domestic conference
    [Invited]
    Invited oral presentation

  • Hepatic Artery Embolization enhances the expressions of TGF-β1 and HIF-1α in a rat hepatoma model
    Eisuke Ueshima, Hideyuki Nishiofuku, Haruyuki Takaki, Yutaka Hirata, Hiroshi Kodama, Toshihiro Tanaka, Kimihiko Kichikawa, Koichiro Yamakado, Takuya Okada, Keitaro Sofue, Masato Yamaguchi, Koji Sugimoto, Takamichi Murakami
    Society of Interventional Oncology, Jun. 2019, Japanese, International conference
    Oral presentation

  • 肝細胞癌に対する放射線照射治療後の経動脈的化学塞栓療法の安全性の検討
    上嶋英介, 小出裕, M.A.S. Hamada, 堀之内宏樹, 岡田卓也, 佐々木康二, 元津倫幸, 谷龍一郎, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    第19回関西肝癌局所療法研究会, Mar. 2019, Japanese, Domestic conference
    Oral presentation

  • 肝動脈塞栓術は免疫抑制性サイトカイン発現に与える影響 -ラット肝癌モデルによる検討-
    上嶋英介, 岡田卓也, 山口雅人, 杉本幸司, 村上卓道, 西尾福英之, 田中利洋, 吉川公彦, 高木治行, 児玉大志, 山門亨一郎
    第1回宮崎関西放射線研究会, Feb. 2019, Japanese, Domestic conference
    [Invited]
    Invited oral presentation

  • Utility of Extracellular Volume Fraction Measured from Multiphasic Contrast-Enhanced Computed Tomography for the Estimation of Pancreatic Fibrosis
    Sofue K, Ueno Y, Ueshima E, Tani R, Maruyama K, Murakami T, Horinouchi H, Okada T, Yamaguchi M, Sugimoto K
    The 104th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA2018), Nov. 2018, English, Chicago, International conference
    Poster presentation

  • 地域に生かす最新癌治療
    上嶋 英介
    第71回 兵庫県医師会医学会, Oct. 2018, Japanese, Domestic conference
    [Invited]
    Public discourse

  • 困ったときに役立つIVR
    上嶋 英介
    第53回 兵庫県放射線医会総会, Oct. 2018, Japanese, Domestic conference
    [Invited]
    Public discourse

  • IMA閉塞例におけるEVAR後のType2エンドリークの検討 予防的IMA塞栓術は有用か？
    岡田 卓也, 元津 倫幸, 山口 雅人, 佐々木 康二, Mostafa Hamada, 谷 龍一郎, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 杉本 幸司, 村上 卓道, 後竹 康子, 中井 秀和, 山中 勝弘, 田中 裕史
    第59回日本脈管学会総会, Oct. 2018, Japanese, 広島, Domestic conference
    Public symposium

  • 破裂性十二指腸静脈瘤に対してバルーン閉塞下逆行性静脈瘤塞栓術を施行した一例
    小出裕, 岡田卓也, 佐々木康二, 元津倫幸, Hamada MAS, 谷龍一郎, 上嶋英介, 祖父江慶太郎, 山口雅人, 杉本幸司, 村上卓道
    第65回関西IVR研究会, Jun. 2018, Japanese, 大阪, Domestic conference
    Oral presentation

  • 肝動脈塞栓術がTGF-β発現に与える影響：ラット肝癌モデルによる検討
    上嶋英介, 岡田卓也, 山口雅人, 杉本幸司, 村上卓道, 西尾福英之, 田中利洋, 吉川公彦, 高木治行, 児玉大志, 山門亨一郎
    第65回関西IVR研究会, Jun. 2018, Japanese, 大阪, Domestic conference
    Oral presentation

  • The feasibility of preoperative embolization for partial resection of hypervascular spinal tumor
    Tani R, Ueshima E, Hamada M, Sasaki K, Maruyama K, Horinouchi H, Gentsu T, Koide Y, Okada T, Sofue K, Yamaguchi M, Sugimoto K, Murakami T
    The Joint Meeting of the 47th Meeting of the Japanese Society of Interventional Radiology & The 13th Meeting of the International Symposium of Interventional Radiology, May 2018, English, JSIR & ISIR, Tokyo, Japan, International conference
    Oral presentation

  • Embolization with NBCA for acute bleeding from pancreatic and peripancreatic arteries
    Sasaki K, Okada T, Mostafa H, Maruyama K, Horinouchi H, Gentsu T, Tani R, Ueshima E, Koide Y, Sofue K, Yamaguchi M, Sugimoto K, Murakami T
    The Joint Meeting of the 47th Meeting of the Japanese Society of Interventional Radiology & The 13th Meeting of the International Symposium of Interventional Radiology, May 2018, English, JSIR & ISIR, Tokyo, Japan, International conference
    Oral presentation

  • TGF-β1 blockade does not enhance immunomodulatory benefit of partial IRE in murine bladder tumor
    Ueshima E, Srimathveeravall G, Fujimori M, Coleman J, Kim K, Vroomen L, Takaki H, Okada T, Yamaguchi M, Sugimoto K
    The Joint Meeting of the 47th Meeting of the Japanese Society of Interventional Radiology & The 13th Meeting of the International Symposium of Interventional Radiology, May 2018, English, JSIR & ISIR, Tokyo, Japan, International conference
    Oral presentation

  • Predictive factors of type 2 endoleaks after EVAR with occluded inferior mesenteric artery
    Okada T, Gentsu T, Yamaguchi M, Sasaki K, Maruyama K, Horinouchi H, Tani R, Ueshima E, Koide Y, Gotake Y, Okita Y, Sugimoto K
    The Joint Meeting of the 47th Meeting of the Japanese Society of Interventional Radiology & The 13th Meeting of the International Symposium of Interventional Radiology, May 2018, English, JSIR & ISIR, Tokyo, Japan, International conference
    Oral presentation

  • Transforming growth factor-β1 blockade after irreversible electroporation of murine urothelial tumor does not provide additional survival or cancer control benefits.
    Masashi Fujimori, Laurien Vroomen, Ueshima Eisuke, Kwanghee Kim, Karan Nagar, Jonathan Coleman, Govindarayan Srimathveeravalli
    SIR2018, Mar. 2018, English, Society of Interventional Radiology, Los Angels, USA, International conference
    [Invited]
    Oral presentation

  • The Effects of Partial Irreversible Electroporation (IRE) on T-cell and Macrophage Population in Murine Bladder Tumor Microenvironment
    Luis Santos, Masashi Fujimori, Laurien Vroomen, Ueshima Eisuke, Kwanghee Kim, Karan Nagar, Jonathan Coleman, Govindarayan Srimathveeravalli
    SIR2018, Mar. 2018, English, Society of Interventional Radiology, Los Angels, USA, International conference
    [Invited]
    Poster presentation

  • Sparing of Collagen and Extracellular Matrix Proteins in Irreversible Electroporation Treated Normal Porcine Lung Promotes T-cell and Macrophage Infiltration Throughout Ablated Tissue
    Masashi Fujimori, Ueshima Eisuke, Laurien Vroomen, Damian Dupuy, Joseph Erinjeri, Stephen Solomon, Govindarayan Srimathveeravalli
    SIR2018, Mar. 2018, English, Society of Interventional Radiology, Los Angels, USA, International conference
    [Invited]
    Public discourse

  • Hypoxic stress induces the overexpression of programmed death ligand 1 and chemokine ligand 17 on rat hepatoma cell lines
    Haruyuki Takaki, Yutaka Hirata, Ueshima Eisuke, Kaoru Kobayashi, Yasukazu Kako, Jun Taniguchi, Koichiro Yamakado
    SIR2018, Mar. 2018, English, Society of Interventional Radiology, Los Angels, USA, International conference
    [Invited]
    Oral presentation

  • 低酸素刺激がサイトカイン産生に与える影響：ラット肝細胞癌株による検討
    Ueshima Eisuke, 高木治行, Okada Takuya, Yamaguchi Masato, 山門亨一郎, Sugimoto Koji
    第63回中部IVR・第64回関西IVR合同研究会, Feb. 2018, Japanese, 中部IVR・関西IVR合同研究会, 愛知, Domestic conference
    [Invited]
    Oral presentation

  • 内臓動脈瘤の血管内治療 内臓動脈瘤に対する血管内治療の経験
    Sugimoto Koji, 谷 龍一郎, Okada Takuya, Ueshima Eisuke, Yamaguchi Masato
    第58回日本脈管学会総会, Oct. 2017, Japanese, 日本脈管学会, 名古屋, Domestic conference
    Public symposium

  • Balloon-occluded retrograde transvenous obliteration for duodenal varices.
    Okada Taro, Maruyama K, Horinouchi H, Gentsu T, Tani R, Usui R, Katayama N, Ueshima Eisuke, Sofue Keitaro, Yamaguchi Masato, Sugimoto Koji
    CIRSE (Cardiovascular and Interventional Radiological Society of Europe) Annual Scientific Meeting, Sep. 2017, English, CIRSE, Copenhagen, Denmark, International conference
    [Invited]
    Poster presentation

  • 動脈塞栓術を施行した腎部分切除術後の仮性動脈瘤の検討
    臼井 亮介, Okada Takuya, 丸山 晃司, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 片山 直人, Ueshima Eisuke, Sofue Keitaro, Yamaguchi Masato, Sugimoto Koji
    第46回日本IVR学会総会, May 2017, Japanese, 日本IVR学会, 岡山, Domestic conference
    [Invited]
    Oral presentation

  • 十二指腸静脈瘤に対するB-RTOの有効性の検討
    丸山 晃司, Okada Takuya, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 片山 直人, Ueshima Eisuke, Sofue Keitaro, Yamaguchi Masato, Sugimoto Koji
    第46回日本IVR学会総会, May 2017, Japanese, 日本IVR学会, 岡山, Domestic conference
    [Invited]
    Oral presentation

  • 腫瘍性脊椎圧骨折に対する経皮的椎体形成術の検討
    谷 龍一郎, Okada Takuya, 丸山 晃司, 堀之内 宏樹, 臼井 亮介, 元津 倫幸, 片山 直人, Ueshima Eisuke, Sofue Keitaro, Yamaguchi Masato, Sugimoto Koji
    第46回日本IVR学会総会, May 2017, Japanese, 日本IVR学会, 岡山, Domestic conference
    [Invited]
    Oral presentation

  • 炎症性腹部大動脈瘤に対するステントグラフト内挿入術(EVAR)の治療成績
    堀之内 宏樹, Okada Takuya, 丸山 晃司, 元津 倫幸, 谷 龍一郎, 片山 直人, Ueshima Eisuke, Yamaguchi Masato, Sugimoto Koji, Gotake Yasuko, 野村 佳克, Okita Yutaka
    第46回日本IVR学会総会, May 2017, Japanese, 日本IVR学会, 岡山, Domestic conference
    [Invited]
    Oral presentation

  • EVAR後にopen conversionに至った症例の検討
    丸山 晃司, Yamaguchi Masato, Okada Takuya, 堀之内 宏樹, 元津 倫幸, 谷 龍一郎, 片山 直人, Ueshima Eisuke, Sugimoto Koji, Gotake Yasuko, 野村 佳克, Okita Yutaka
    第46回日本IVR学会総会, May 2017, Japanese, 日本IVR学会, 岡山, Domestic conference
    [Invited]
    Oral presentation

  • Mid-long term results of endovascular abdominal aortic aneurysm repair with Endurant stent graft system
    Yamaguchi Masato, 丸山晃司, 堀之内宏樹, 谷龍一郎, 元津倫幸, 片山直人, Ueshima Eisuke, Okada Takuya, Sugimoto Koji, 野村佳克, Gotake Yasuko, Okita Yutaka
    The 46th Annual Meeting of the Japanese Society of Interventional Radiology, May 2017, Japanese, Japanese society of interventional radiology, 岡山, 【目的】Endurant○Rステントグラフトを用いた腹部大動脈瘤（AAA）に対するステントグラフト内挿術（EVAR）の中長期成績を検討すること。【方法】対象は2012年から2016年に神戸大学病院および関連施設でAAAに対してEndurant○Rを用いたEVARが施行され、6か月以上の観察を行った134例。（男性118例、年齢は75.1±8.5歳、大動脈瘤最大短径は平均52.4±7.7mm、IFU内症例は89例（66％））後方視的に動脈瘤サイズ変化、エンドリーク（EL）、動脈瘤関連の再治療について検討した。【結果】全134例の平均観察期間は19±11月で、経過観察中の全死亡例は6例（4.5％）であったが、動脈瘤関連死はなかった。動脈瘤のサイズ変化は瘤縮小（5mm以上）50例（37％）、不変79例（59％）、拡大（5mm以上）5例（4％）であった。経過, Domestic conference
    [Invited]
    Oral presentation

  • EndurantステントグラフトによるEVARの中長期成績
    Yamaguchi Masato, 丸山 晃司, 堀之内 宏樹, 谷 龍一郎, 元津 倫幸, 片山 直人, Ueshima Eisuke, Okada Takuya, Sugimoto Koji, 野村 佳克, Gotake Yasuko, Okita Yutaka
    第46回日本IVR学会総会, May 2017, Japanese, 日本IVR学会, 岡山, Domestic conference
    [Invited]
    Poster presentation

  • Embolization for spontaneous adrenal hemorrhage.
    Gentsu T, Okada Taro, Katayama N, Tani R, Ueshima Eisuke, Koide Y, Sofue Keitaro, Yamaguchi Masato, Sugimoto Koji
    Cardiovascular and Interventional Radiological Society of Europe, Sep. 2016, English, Cardiovascular and Interventional Radiological Society of Europe, Barcelona, Spain, International conference
    [Invited]
    Oral presentation

  • Double balloon-occluded retrograde transvenous obliteration (BRTO) using a pull-through technique for the treatment of duodenal varices with two draining veins.
    Koide Y, Okada Taro, Gentsu T, Tani R, Katayama N, Ueshima Eisuke, Sofue K, Yamaguchi Masato, Sugimoto Koji
    Cardiovascular and Interventional Radiological Society of Europe, Sep. 2016, English, Cardiovascular and Interventional Radiological Society of Europe, Barcelona, Spain, International conference
    [Invited]
    Oral presentation

  • Combination therapy using denosumab and transarterial embolization for symptomatic sacral giant cell tumor.
    Tani R, Okada Taro, Gentsu T, Katayama N, Ueshima Eisuke, Koide Y, Sofue Keitaro, Yamaguchi Masato, Sugimoto Koji
    Cardiovascular and Interventional Radiological Society of Europe, Sep. 2016, English, Cardiovascular and Interventional Radiological Society of Europe, Barcelona, Spain, International conference
    [Invited]
    Oral presentation

  • ブタ肝後面下大静脈損傷モデルを用いたステントグラフトによる止血効果の検討
    井戸口 孝二, Yamaguchi Masato, 片山 直人, Okada Takuya, Ueshima Eisuke, Sofue Keitaro, 井芹 俊恵, 林 聡恵, 三重 慧一郎, 水島 靖明, Sugimoto Koji
    The Annual Meeting of Japanese Society of Interventional Radiology, May 2016, Japanese, Japanese Society of Interventional Radiology, 名古屋, Domestic conference
    [Invited]
    Oral presentation

  • ビーズ導入後のTACEの現状 多発肝細胞癌に対する非選択的DEB-TACEの有用性の検討
    Okada Takuya, 谷 龍一郎, 元津 倫幸, 片山 直人, Ueshima Eisuke, 小出 裕, Sofue Keitaro, Yamaguchi Masato, Sugimoto Koji
    The Annual Meeting of Japanese Society of Interventional Radiology, May 2016, Japanese, Japanese Society of Interventional Radiology, 名古屋, Domestic conference
    [Invited]
    Oral presentation

  • EVAR後のDistal sealing zoneの形態変化と遅発性type 1bエンドリークの危険因子に関する検討
    元津 倫幸, Okada Takuya, 谷 龍一郎, 片山 直人, Ueshima Eisuke, 小出 裕, Yamaguchi Masato, Sugimoto Koji, Gotake Yasuko, Nomura Yoshikatsu, Okita Yutaka
    The Annual Meeting of Japanese Society of Interventional Radiology, May 2016, Japanese, Japanese Society of Interventional Radiology, 名古屋, Domestic conference
    [Invited]
    Oral presentation

  • Endurantステントグラフトを用いたEVARにおける予防的IMA塞栓群・非塞栓群の比較・検討
    片山 直人, Yamaguchi Masato, 元津 倫幸, 谷 龍一郎, Ueshima Eisuke, 小出 裕, Okada Takuya, Sugimoto Koji, Gotake Yasuko, Nomura Yoshikatsu, Okita Yutaka
    The Annual Meeting of Japanese Society of Interventional Radiology, May 2016, Japanese, Japanese Society of Interventional Radiology, 名古屋, Domestic conference
    [Invited]
    Oral presentation

  • EndurantステントグラフトによるEVARの中長期成績
    小出 裕, Yamaguchi Masato, 谷 龍一郎, 元津 倫幸, 片山 直人, Ueshima Eisuke, Okada Takuya, Sugimoto Koji, Nomura Yoshikatsu, Gotake Yasuko, Okita Yutaka
    The Annual Meeting of Japanese Society of Interventional Radiology, May 2016, Japanese, Japanese Society of Interventional Radiology, 名古屋, Domestic conference
    [Invited]
    Oral presentation

  • Angiographic classification of uterine artery may predict failure of UAE for postpartum hemorrhage
    Sugimoto Koji, Ueshima Eisuke, Yamaguchi Masato, Okada Taro, Muradi A, Katayama N, Koide Y, Sofue Keitaro
    The 12th Asia-Pacific Congress of Cardiovascular and Interventional Radiology, Apr. 2016, English, Asia-Pacific society of Cardiovascular and Interventional Radiology, Suzhou, CHINA, International conference
    [Invited]
    Oral presentation

  • 内腸骨動脈空置瘤に対して経動脈的塞栓術を施行した2例
    小出 裕, Okada Takuya, Muradi Akhamadu, 片山 直人, Ueshima Eisuke, Yamaguchi Masato, Sugimoto Koji, Nomura Yoshikatsu, Okita Yutaka
    第59回関西IVR研究会, 2015, Japanese, 日本IVR学会, 大阪, Domestic conference
    Oral presentation

  • 当院における薬剤溶出性球状塞栓物質を用いたTACE(DEB-TACE)の初期経験
    片山 直人, Okada Takuya, Muradi Akhmadu, Ueshima Eisuke, 小出 裕, Sofue Keitaro, Yamaguchi Masato, Sugimoto Koji
    第60回関西IVR研究会, 2015, Japanese, 日本IVR学会, 大阪, Domestic conference
    Oral presentation

  • 前下膵十二指腸動脈瘤破裂により十二指腸水平脚に高度狭窄を来した一例
    小出 裕, Okada Takuya, Muradi Akhamadu, 片山 直人, Ueshima Eisuke, Yamaguchi Masato, Sugimoto Koji
    第61回関西IVR研究会, 2015, Japanese, 日本IVR学会, 大阪, Domestic conference
    Oral presentation

  • 当院における非外傷性特発性後腹膜出血に対する動脈塞栓術の検討
    片山 直人, Sofue Keitaro, Muradi Akhmadu, Ueshima Eisuke, Okada Takuya, 井戸口 孝二, Yamaguchi Masato, Sugimoto Koji
    第59回関西IVR研究会, 2014, Japanese, 日本IVR学会, 大阪, Domestic conference
    Oral presentation

  • 巨細胞動脈炎の関与が疑われる両側上腕動脈病変に対しPTAを施行した2例
    Ueshima Eisuke, Yamaguchi Masato, 井戸口 孝二, Sofue Keitaro, Okada Takuya, 片山 直人, Muradi Akhmadu, Sugimoto Koji
    第58回関西IVR研究会, 2014, Japanese, 日本IVR学会, 大阪, Domestic conference
    Oral presentation

  • Management of type II endoleak after endovascular repair of arteriocaval fistula complicating aortoiliac aneurysm: case report and literature review
    Akhmadu Muradi, Yamaguchi Masato, Ueshima Eisuke, Okada Takuya, Koji Idoguchi, Nomura Yoshikatsu, Okita Yutaka, Sugimoto Koji
    16th Congress Asian Society for Vascular Surgery (ASVS) and 9th Asian Venous Forum, 2014, English, Asian Society for Vascular Surgery (ASVS), 香港, 中国, International conference
    [Invited]
    Poster presentation

  • 腹腔動脈起始部狭窄に伴う下膵十二指腸動脈瘤破裂に対するTAE後に十二指腸狭窄をきたした1例
    Sofue Keitaro, Yamaguchi Masato, Idoguchi Koji, Okada Takuya, Ueshima Eisuke, Akhmadu Muradi, 片山直人, Sugimoto Koji
    関西IVR地方会, Jun. 2013, Japanese, 関西IVR学会, 大阪, Domestic conference
    [Invited]
    Oral presentation

  • 腹部大動脈瘤に対するステントグラフト内挿術の適応拡大における問題点
    Nomura Yoshikatsu, 後竹 康子, 木下 史子, 小原 大見, 中井 秀和, Yamanaka Katsuhiro, Shirasaka Tomonori, 竹歳 秀人, Miyahara Shunsuke, Sakamoto Toshihito, Omura Atsushi, Inoue Takeshi, 南 一司, Okada Kenji, Ueshima Eisuke, Idoguchi Koji, Yamaguchi Masato, Sugimoto Koji, Okita Yutaka
    The 113rd Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, The Japan Surgical Society, 福岡, Domestic conference
    [Invited]
    Oral presentation

  • 鎖骨下静脈からの中心静脈カテーテル挿入に伴う胸肩峰動脈損傷に対して動脈塞栓術を施行した2例
    Sofue Keitaro, Yamaguchi Masato, 坂本憲昭, 奥野晃章, Idoguchi Koji, Ueshima Eisuke, Sugimoto Koji, 川崎竜太
    日本IVR学会第33回関西地方会, Feb. 2013, Japanese, 日本IVR学会, 大阪, Domestic conference
    [Invited]
    Oral presentation

  • 外傷性胸部大動脈損傷に対するMatsui-Kitamuraステントグラフト留置術の有用性
    Yamaguchi Masato, Sugimoto Koji, 森岳樹, 伊崎健太, 魚谷健祐, 奥野晃章, Okada Takuya, Ueshima Eisuke, 藤井正彦, Sugimura Kazuro, 築部卓郎, 松川律, 原口知則, 小澤修一, 北川敦士, Nomura Yoshikatsu, Okita Yutaka
    第38回日本IVR学会総会, Aug. 2009, Japanese, 日本IVR学会, 大阪, Domestic conference
    [Invited]
    Oral presentation

  • Lenvatinibが塞栓術後の癌微小環境中の免疫状態に与える影響~Rat肝癌モデルによる検討~
    第48回 播淡画像研究会
    [Invited]

■ Affiliated Academic Society
  • 日本肝癌研究会

  • The Japan Society of Hepatology

  • Japanese Society of Interventional Radiology

  • JAPAN RADIOLOGICAL SOCIETY

■ Research Themes
  • 低酸素刺激は肝細胞癌の TLS をいかに変えるのか -空間オミクスによる解明と⾼内⽪静脈再構築への応⽤-
    武田科学振興財団, 医学系研究助成（がん領域（臨床））, Sep. 2026 - Dec. 2031, Principal investigator

  • FAPI-PET/MRIと空間Omics解析統合による肝細胞癌免疫治療バイオマーカー開発
    村上 卓道, 野上 宗伸, 上嶋 英介, 祖父江 慶太郎
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2026 - 31 Mar. 2029

  • ドライバー遺伝子に基づくTACE治療反応性の血清バイオマーカーの開発
    上嶋 英介, 平田 豊, 小松 昇平, 祖父江 慶太郎
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2023 - 31 Mar. 2026

  • Development of non-invasive biomarker to predict therapeutic efficacy of immunotherapy for hepatocellular carcinoma
    村上 卓道, 鶴崎 正勝, 上嶋 英介, 小松 正人, 祖父江 慶太郎
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2023 - 31 Mar. 2026

  • 深部臓器発生の悪性腫瘍に対する新規放射線増感療法としての飽和炭酸水動注療法の開発
    元津 倫幸, 山口 雅人, 石原 武明, 佐々木 康二, 上嶋 英介, 岡田 卓也, 清水 康之, 杉本 幸司
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2022 - 31 Mar. 2026

  • 肝細胞癌に対するTACE治療効果を予測する血清バイオマーカー開発
    公益社団法人 ひょうご科学技術協会, 学術研究助成, Apr. 2025 - Mar. 2026, Principal investigator

  • 人工知能を用いた膵癌CT自動診断システム開発とスクリーニング・早期診断への応用
    祖父江 慶太郎, 村上 卓道, 上嶋 英介, 上野 嘉子, 増田 充弘
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2022 - 31 Mar. 2025
    腹部造影CT画像に対して画像AI技術を用い、膵腫瘤および膵癌に付随する頻度の高い二次所見（主膵管拡張、主膵管狭窄、膵萎縮）の自動検出による膵癌自動診断システムの構築を試みた。深層学習を用いて、膵実質、膵管、腫瘤の各領域を自動抽出し、抽出結果に基づき膵腫瘤性病変ならびに二次所見の有無を判定可能なAIエンジンを構築した。トレーニングセット・バリデーションセットとして膵癌群587例、対照群432例を用い、テストデータとして関連施設より収集した膵癌群62例、対照群90症例を対象に、膵腫瘤検出AI単独による膵癌検出精度ならびに膵腫瘤検出AIと二次所見検出AIの組合せによる膵癌検出精度を評価・算出した。 テストデータにおける腫瘤検出AIのみによる膵癌検出能は、感度73.3%、特異度96.7%であった。腫瘤検出AIと二次所見検出AIの組合せによる膵癌検出能は、感度93.5%、特異度84.4%であった。二次所見検出AIを組み合わせることにより検出感度が向上するとともに、腫瘤検出AI単独では検出できなかったTisやT1等の小膵癌に対しても検出成功例が増加した。

  • 肝動脈塞栓術後のガン微小環境におけるマクロファージ極性制御に基づく新規治療戦略
    上嶋 英介, 平田 豊, 児玉 大志, 祖父江 慶太郎, 村上 卓道
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2020 - 31 Mar. 2023
    luciferase遺伝子導入N1S1ラット肝癌細胞を用いて同種移植肝癌モデルを作成した。腫瘍移植後7日目に頸動脈より細経のマイクロカテーテルを挿入し、肝動脈 を選択し、破砕したゼラチン物質にて腫瘍動脈の塞栓術を行った。さらに1週間後にIVISにて腫瘍壊死および残存組織の発光をIVISにて確認した。その後、 Sacrificeを行い、肝癌移植・辺縁部をまとめて摘出し、mRNA抽出を行い、microarrayによる網羅的遺伝子解析を行った。TAE群ではTAMに関与する遺伝子群の発現が増加傾向にあり、これらはLenvatinib併用群では減少する傾向にあった。TAEにより生じた腫瘍免疫微小環境のTAM増加に向かう変化がLenvatinibにより修正されうる可能性が示唆された。さらにラット脛骨より骨髄細胞を採取し、M-CSF投与によりマクロファージへと分化させ た。同骨髄由来マクロファージとN1S1細胞を用いてマクロファージ極性変化を評価した。Lenvatinibとマクロファージのみに投与しても極性変化は見られなかっ たが、N1S1のConditioned mediumを加えるとマクロファージ極性変化が生じ、Lenvatinib投与により改善が見られた。よって、Lenvatinibはマクロファージに作 用するのではなく、腫瘍細胞に作用し、その結果、腫瘍より放出されるサイトカインによりマクロファージ極性変化が生じることが予想された。 以上の結果をまとめて、関連学会にて報告、英文校正を経て関連学会雑誌に投稿中である。

  • ヨードマップを用いた膵癌の線維性間質定量による悪性度および治療抵抗性の予測法確立
    祖父江 慶太郎, 村上 卓道, 上嶋 英介, 上野 嘉子, 増田 充弘
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2019 - 31 Mar. 2022
    本研究の目的はDual-Energy CTで撮像したダイナミック造影CTから得られるヨードマップを用いて膵癌内部の線維性間質の多寡を定量測定することにより、非侵襲的に膵癌の悪性度ならびに治療抵抗性の予測を行うことである． 最終目的の前の先行研究として、膵癌線維化マーカーであるCollagen fiberならびに活性化膵星細胞と予後との関連を後方視的に評価した。2008年から2017年の間に神戸大学病院において膵癌に対して手術加療が行われた通常型膵管癌162症例に対してCollagen量を評価するEVG染色、活性化膵星細胞を評価するα-SMA染色を行った。それぞれの全体における染色割合をPhotoshopで算出し、その多寡で予後を評価した所、Collagen fiberが高度な膵癌は軽度な膵癌と比較して生存率が有意に延長（Log-rank test P=0.001）、α-SMA陽性細胞が高度の膵癌は軽度な膵癌と比較して生存率が有意に延長していた（Log-rank test P=0.001）。また線維化高度な膵癌では腫瘍内のCD8陽性T細胞が多いことも判明した。この結果から、膵癌においては線維化が高度な症例で予後が良く、腫瘍内免疫状態とも関連している可能性が示唆された。 続いて、上記対象162膵癌に対して造影CT平衡相画像から線維化を予測可能かを評価した。線維化予測指標としてECV fractionを利用して18例において評価を行った所、ECV fractionとCollagen fiberの程度に中等度の相関が見られたが（ρ=0.641、P=0.034）、α-SMA陽性細胞との程度には相関は認められなかった（ρ=0.352、P=0.289）。造影CT平衡相における評価は検討症例数を増やすとともに、ヒストグラム解析の追加を検討している。 また、Dual-Energy CTを用いた膵癌線維性間質の評価を行うための研究に対して倫理委委員会の承認が得られ、実施体制を整えることができた。

  • Transarterial infusion of metallic nanoparticles for radiation therapy enhancement
    Okada Takuya
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2017 - 31 Mar. 2021
    Twelve female rabbits with VX2 thigh tumors were divided into the three groups: Intraarterial (IA), balloon occlusion arterial (BOA), and intravenous (IV) infusion groups. 10 ml of PAA-TiOx NPs (10 mg/ml) were infused through an external iliac artery in the IA and BOA groups and a marginal ear vein in the IV group. The median accumulation rates of PAA-TiOx NPs in VX2 tumor were 0.119, 0.078 and 0.117 weight percent, and the median concentration of NPs in VX2 tumor was 0.0026, 0.0015, and 0.0034 mg/g tissue in the IA, BOA and IV groups, respectively. There were no statistically differences between the IA and IV groups, and nor between the BOA and IV groups. PAA-TiOx NPs accumulated most in liver at 10.9306, 16.2188 and 25.7768 weight percent, and second most in spleen at 0.8686, 0.7624 and 2.4372 weight percent in the IA, BOA and IV groups. Intraarterial infusion did not increase the accumulation of PAA-TiOx NPs in VX2 tumor compared with intravenous infusion.

  • 肝癌局所療法後に生じる免疫抑制性サイトカイン産生メカニズムの解明および阻害法の探索
    上嶋 英介
    兵庫県健康財団, 癌研究奨励賞, Jul. 2019 - Jun. 2020, Principal investigator
    Competitive research funding

  • Ueshima Eisuke, Takaki Haruyuki, Kodama Hiroshi, Nishiofuku Hideyuki, Hirata Yutaka
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Kobe University, 01 Apr. 2017 - 31 Mar. 2019
    Rats bearing N1S1 hepatoma cells underwent HAE. Animals were euthanized at 48h, and liver tissues were harvested. IHC and qPCR were performed to compare the expression of TGF-β1. In vitro experiments with the N1S1 cell line were performed under hypoxic conditions for 48h, and the expression of TGF-β1 and HIF-1α was assessed with western blotting and ELISA. IHC showed that both the TGF-β1 and HIF-1α-positive areas were larger in the HAE group than in the sham group. Similarly, qPCR showed that the mRNA expression levels of TGF-β1 and HIF-1α were higher in the HAE group than those in the sham group. TGF-β1 expression was suppressed when HIF-1α inhibitors were added, and HIF-1α expression was upregulated when exogenous TGF-β1 was added in N1S1 cells.

  • YAMAGUCHI Masato, KATAYAMA Naoto
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2016 - 31 Mar. 2019
    This study aimed to evaluate the efficacy of an intra-arterially infused carbon dioxide (CO2)-saturated solution in sensitizing the anti-cancer effect of cisplatin in a rabbit VX2 liver tumor model. Forty VX2 liver tumor-bearing Japanese white rabbits were randomly divided into four groups and infused via the hepatic artery with a saline solution (control group, CO2 group, cisplatin group, and combined group). The tumor growth ratios were calculated on days 3 and 7. Hypoxia (HIF-1α) and apoptosis (cleaved caspase-3) were evaluated on day 7. The tumor growth ratio was significantly lower in the CO2 group than in the control group (day 3), and in the combined group than in the cisplatin group (days 3 and 7). HIF-1α suppression and increased cleaved caspase-3 expression were detected in the CO2 and combined groups, compared with the other two groups. An intra-arterially infused CO2-saturated solution inhibits liver VX2 tumor growth and sensitizes the anti-cancer effect of cisplatin.
    Competitive research funding

  • 肝細胞癌に対するレンバチニブとTACE併用療法：ラット肝癌モデルを用いた検討
    上嶋 英介
    日本医学放射線学会, 2018年度Bayer研究助成受賞, Apr. 2018 - Mar. 2019, Principal investigator
    Competitive research funding

  • Idoguchi Koji, Yamaguchi Masato, Sofue Keitaro, Sugimoto Koji, Okada Takuya, Ueshima Eisuke, Akhmadu Muradi, Iseri Toshie, Hayashi Akiyoshi, Mie Keiichiro, Usui Ryosuke, Yamada Mami, Hira Eiji
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2013 - 31 Mar. 2016
    The current study has been conducted aiming at developing a new endovascular treatment for traumatic juxtahepatic inferior vena cava injury. In spite of an experiment conducted at first for developing new balloon catheter using a swine, any effective inferior vena cava perfusion was not obtained and we were forced to change the shape. At the second stage, we have successfully established a swine juxtahepatic inferior vena cava injury model which had not been reported up to now. In an examination continuously performed on whether hemostasis is possible or not by endovascular treatment for the injury model, a hemostatic effect was observed using endografts. Therefore, we have advanced a development of new removable device with hemostatic effect equivalent of endograft. At the final stage of improvement work for the device as of now, we have been conducting additional experiments aiming at earlier completion.

  • UESHIMA Eisuke
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Kobe University, 01 Apr. 2013 - 31 Mar. 2015, Principal investigator
    It is important to make the new method of aortic aneurysm model in order to find out the new treatment for aortic aneurysm. We had the experiments of making the aortic aneurysm model with the catheter which is a narrow tube. As a result, we could make the aortic aneurysm model. However, it was very low rate to make the aneurysm model and the shapes were irregular. It was not useful as an aortic anerysm model.
    Competitive research funding

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