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AKISUE ToshihiroGraduate School of Health Sciences / Faculty of Health SciencesProfessor
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■ Award- Nov. 2020 第４回日本リハビリテーション医学会秋季学術集会, YIA優秀賞, 骨転移キャンサーボードを用いたリハビリテーション治療における患者QOLに影響を与える因子の検討
- Feb. 2019 整形外科集談会 京阪神地方会, 京阪神集談会Best Paper Award, 膝関節軟骨穿破を伴ったBrodie膿瘍を長期経過観察した一例
- Oct. 2014 APOA/RCOST, 2014 APOA/RCOST Meeting No.1 Poster Presentation Award, YM155, A Novel Small Molecule Survivin Suppressant, Suppresses Tumor Progression With Increased Mitochondrial Apoptosis In Human Malignant Fibrous Histiocytoma Cells.
- Jun. 2012 日本整形外科外科学会, 平成25年度(2013年)日本整形外科学会 AOA traveling fellow
- Jul. 2011 日本整形外科学会, 第44回日本整形外科学会 骨・軟部腫瘍学術集会 優秀ポスター賞, ホウ素中性子捕捉療法（BNCT)を用いた明細胞肉腫に対する新しい治療方法
- BACKGROUND: Upper extremity impairments in patients with breast cancer persist after curative surgery. Although postoperative factors associated with upper extremity impairments have been reported, modifiable factors affecting these impairments preoperatively remain unclear. This study aimed to investigate the relationship between preoperative grip strength and postoperative upper extremity impairments in patients with breast cancer. METHODS: This retrospective cohort study included patients (age ≥ 18 years) with breast cancer who underwent mastectomy. Maximum grip strength was measured on the day before surgery. Upper extremity impairments were assessed 4-16 months after surgery using the Disabilities of the Arm, Shoulder and Hand (DASH) scale. Multiple linear regression analysis was used to evaluate the association between preoperative grip strength and postoperative upper extremity impairments. RESULTS: In total, 72 patients were included in the analysis. Multiple linear regression analysis showed that preoperative grip strength was significantly associated with the postoperative DASH score after adjusting for confounding factors (β = - 1.27, 95% confidence interval - 2.08 to - 0.48, p = 0.002). CONCLUSIONS: This study showed that low preoperative grip strength is a risk factor for postoperative upper extremity impairments in patients with breast cancer. Providing prehabilitation to maintain and improve muscle strength immediately after diagnosis is important. Moreover, an individualized follow-up protocol according to preoperative screenings to prevent postoperative upper extremity impairments is necessary.Apr. 2025, Breast cancer (Tokyo, Japan), English, Domestic magazineScientific journal
- Myxofibrosarcoma, a rare malignant tumor, predominantly affects the extremities of the elderly. Because of its invasive nature amputation is sometimes required, resulting in serious deterioration of quality of life. Therefore, cell lines established from amputated surgical specimens of myxofibrosarcoma in the upper limbs of elderly patients were used to create a myxofibrosarcoma-bearing animal model and to investigate the therapeutic effect of BNCT thereon. The results demonstrated selective destruction of tumor cells, suggesting the anti-tumor efficacy of BNCT on myxofibrosarcoma.Mar. 2025, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 217, 111603 - 111603, English, International magazineScientific journal
- Cancer stem cells (CSCs) have been implicated as critical mediators in the progression, chemoresistance and metastatic capabilities of diverse malignancies, including osteosarcoma (OS). The authors have succeeded in generating CSC‑like cells (MG‑OKS) from the OS cell line MG‑63 by transducing defined factors. A significant increase in small proline‑rich protein 1A (SPRR1A) expression, a cross‑linked envelope protein in keratinocytes, was observed in MG‑OKS cells. Therefore, SPRR1A could be involved in tumor initiation, growth and poor OS progression. However, its specific role in OS remains unclear. The present study aimed to evaluate the role of SPRR1A in OS both in vitro and in vivo using MG‑OKS cells. Three experimental groups were established: MG‑OKS cells transfected with SPRR1A small interfering (si)RNA (siMG‑OKS), untransfected MG‑OKS cells and MG‑OKS cells transfected with scrambled siRNA (scMG‑OKS) as controls. SPRR1A expression, morphological changes, cell proliferation and migration were assessed in these groups. RNA sequencing was performed to examine the genetic changes caused by SPRR1A suppression. To evaluate tumorigenicity in vivo, cells from each group were subcutaneously transplanted into the backs of nude mice. Tumor volume and Ki‑67 expression were assessed and compared among the three groups at four weeks post‑transplantation. The siMG‑OKS group exhibited altered cell morphology, reduced cell proliferation and decreased migratory abilities in vitro. RNA sequencing revealed suppression of genes involved in cell adhesion in the siMG‑OKS group. Furthermore, the in vivo tumorigenicity of siMG‑OKS was lower than that of the other two experimental groups. These findings suggest that SPRR1A is one of the key cell adhesion‑related molecules involved in OS progression, potentially serving as a therapeutic target for this refractory tumor. However, further research is needed to fully elucidate the mechanisms by which SPRR1A influences OS pathogenesis and to explore its clinical potential.Feb. 2025, Oncology reports, 53(2) (2), English, International magazineScientific journal
- BACKGROUND: In Japan, there are currently no general guidelines for the treatment of primary malignant bone tumors. Therefore, the Japanese Orthopaedic Association established a committee to develop guidelines for the appropriate diagnosis and treatment of primary malignant bone tumors for medical professionals in clinical practice. METHODS: The guidelines were developed in accordance with "Minds Clinical Practice Guideline Development Handbook 2014″ and "Minds Clinical Practice Guideline Development Manual 2017". The Japanese Orthopaedic Association's Bone and Soft Tissue Tumor Committee established guideline development and systematic review committees, drawing members from orthopedic specialists leading the diagnosis and treatment of bone and soft tissue tumors. Pediatricians, radiologists, and diagnostic pathologists were added to both committees because of the importance of multidisciplinary treatment. Based on the diagnosis and treatment algorithm for primary malignant bone tumors, important decision-making points were selected, and clinical questions (CQ) were determined. The strength of recommendation was rated on two levels and the strength of evidence was rated on four levels. The recommendations published were selected based on agreement by 70% or more of the voters. RESULTS: The guideline development committee examined the important clinical issues in the clinical algorithm and selected 22 CQs. The systematic review committee reviewed the evidence concerning each CQ and a clinical value judgment was added by experts. Eventually, 25 questions were published and the text of each recommendation was determined. CONCLUSION: Since primary malignant bone tumors are rare, there is a dearth of strong evidence based on randomized controlled trials, and recommendations cannot be applied to all the patients. In clinical practice, appropriate treatment of patients with primary malignant bone tumors should be based on the histopathological diagnosis and degree of progression of each case, using these guidelines as a reference.Jan. 2025, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 30(1) (1), 1 - 17, English, Domestic magazineScientific journal
- Last, Dec. 2024, 理学療法兵庫, 30, 29 - 31, Japanese乳がん患者を対象とした術前握力と術後上肢機能障害の関連に関する観察研究[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 68 - 68, Japaneseがんロコモ対策の現状と課題 四肢骨転移に対する治療の現状と課題
- (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 92 - 92, Japanese整形外科における女性医師キャリア形成の現状と課題 自身のキャリア形成の現状と課題 1度手術を手放した私が再び手術を学ぶチャンスをつかむまで
- (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 269 - 269, Japanese膝関節内に巨大腫瘤を形成し腱滑膜巨細胞腫との鑑別を要した滑膜軟骨腫症の一例
- (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 269 - 269, Japanese肘部管症候群を合併した右肘滑膜軟骨腫症の一例
- (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 320 - 320, Japanese骨肉腫細胞におけるSPRR1Aの機能の探索 新規開発骨肉腫がん幹細胞様細胞を用いた検討
- (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 320 - 320, JapaneseEwing肉腫におけるslow-cycling-cellsの特性の探索 次世代シーケンス解析を用いた検討
- (一社)日本足の外科学会, Oct. 2024, 日本足の外科学会雑誌, 45(2) (2), S270 - S270, Japanese人工足関節置換術後患者における足趾把持力と歩行能力の関係について
- Sep. 2024, ChildrenScientific journal
- (公社)日本整形外科学会, Sep. 2024, 日本整形外科学会雑誌, 98(8) (8), S1964 - S1964, Japanese
- (公社)日本整形外科学会, Sep. 2024, 日本整形外科学会雑誌, 98(8) (8), S1967 - S1967, Japanese
- BACKGROUND: Few studies have compared the clinical outcomes of patients with pelvic bone sarcomas treated surgically and those treated with particle beam therapy. This is a multicenter retrospective cohort study which compared the clinical outcomes of patients with pelvic bone sarcoma who underwent surgical treatment and particle beam therapy in Japan. METHODS: A total of 116 patients with pelvic bone sarcoma treated at 19 specialized sarcoma centers in Japan were included in this study. Fifty-seven patients underwent surgery (surgery group), and 59 patients underwent particle beam therapy (particle beam group; carbon-ion radiotherapy: 55 patients, proton: four patients). RESULTS: The median age at primary tumor diagnosis was 52 years in the surgery group and 66 years in the particle beam group (P < 0.001), and the median tumor size was 9 cm in the surgery group and 8 cm in the particle beam group (P = 0.091). Overall survival (OS), local control (LC), and metastasis-free survival (MFS) rates were evaluated using the Kaplan-Meier method and compared among 116 patients with bone sarcoma (surgery group, 57 patients; particle beam group, 59 patients). After propensity score matching, the 3-year OS, LC, and MFS rates were 82.9% (95% confidence interval [CI], 60.5-93.2%), 66.0% (95% CI, 43.3-81.3%), and 78.4% (95% CI, 55.5-90.5%), respectively, in the surgery group and 64.9% (95% CI, 41.7-80.8%), 86.4% (95% CI, 63.3-95.4%), and 62.6% (95% CI, 38.5-79.4%), respectively, in the particle beam group. In chordoma patients, only surgery was significantly correlated with worse LC in the univariate analysis. CONCLUSIONS: The groups had no significant differences in the OS, LC, and MFS rates. Among the patients with chordomas, the 3-year LC rate in the particle beam group was significantly higher than in the surgery group.Jul. 2024, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, English, Domestic magazineScientific journal
- Objective: To develop a combined index using cognitive function and instrumental activities of daily living (IADL) to discriminate between Clinical Dementia Rating (CDR) scores of 0.5 and 1 in the clinical setting, and to investigate its optimal cutoff values and internal and external validities. Methods: We included outpatients aged 65-89 years with CDR scores of 0.5 or 1. The optimal cutoff values and internal validity were verified using Japanese memory clinic-based datasets between September 2010 and October 2021 [National Center for Geriatrics and Gerontology (NCGG) datasets]. Cognitive function and IADL were assessed using the Mini-Mental State Examination (MMSE) and Lawton Index (LI), respectively. The optimal cutoff values were defined using the Youden Index. To verify internal validity, sensitivity and specificity were calculated using stratified 5-fold cross-validation. To verify external validity, sensitivity and specificity of the optimal cutoff values were assessed in the Organized Registration for the Assessment of dementia on Nationwide General consortium toward Effective treatment (ORANGE) Registry dataset between July 2015 and March 2022, which has multicenter clinical data. Results: A total of 800 (mean age, 77.53 years; men, 50.1%) and 1494 (mean age, 77.97 years; men, 43.3%) participants comprised the NCGG and ORANGE Registry datasets, respectively. The optimum cutoff values for men and women were determined as MMSE < 25 and LI < 5 and MMSE < 25 and LI < 8, respectively; such a combined index showed good discriminative performance in internal (sensitivity/specificity: men, 92.50/73.52; women, 88.57/65.65) and external validities (men, 81.43/77.62; women, 77.64/74.67). Conclusion: The index developed is useful in discriminating between CDR scores of 0.5 and 1 and should be applicable to various settings, such as memory clinics and clinical research.May 2024, The Journal of clinical psychiatry, 85(2) (2), English, International magazineScientific journal
- May 2024, Journal of geriatric oncology, 101782 - 101782, English, International magazineScientific journal
- (公社)日本整形外科学会, Mar. 2024, 日本整形外科学会雑誌, 98(3) (3), S1250 - S1250, Japanese
- (一社)日本腎臓リハビリテーション学会, Mar. 2024, 日本腎臓リハビリテーション学会誌, 3(1) (1), 61 - 68, Japanese
- THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, Mar. 2024, The Central Japan Journal of Orthopaedic Surgery & Traumatology, 67(2) (2), 167 - 168, Japanese
- OBJECTIVES: This study aimed to investigate the association between abdominal adiposity and change in cognitive function in community-dwelling older adults. DESIGN, SETTING, AND PARTICIPANTS: This longitudinal study included older adults aged ≥60 years without cognitive impairment who participated in the National Institute for Longevity Sciences - Longitudinal Study of Aging. MEASUREMENTS: Cognitive function was evaluated biennially using the Mini-Mental State Examination (MMSE) over 10 years. Waist circumference (WC) was measured at the naval level, and subcutaneous fat area (SFA) and visceral fat area (VFA) were assessed using baseline computed tomography scans. WC, SFA, and VFA areas were stratified into sex-adjusted tertiles. A linear mixed model was applied separately for men and women. RESULTS: This study included 873 older adults. In men, the groups with the highest levels of WC, SFA, and VFA exhibited a greater decline in MMSE score than the groups with the lowest levels (β [95% confidence interval]: WC, -0.12 [-0.23 to -0.01]; SFA, -0.13 [-0.24 to -0.02]; VFA, -0.11 [-0.22 to -0.01]). In women, the group with the highest level of WC and SFA showed a greater decline in MMSE score than the group with the lowest level (WC, -0.12 [-0.25 to -0.01]; SFA, -0.18 [-0.30 to -0.06]), but VFA was not associated with cognitive decline. CONCLUSION: Higher WC, SFA, and VFA in men and higher WC and SFA in women were identified as risk factors for cognitive decline in later life, suggesting that abdominal adiposity involved in cognitive decline may differ according to sex.Elsevier BV, Mar. 2024, The Journal of nutrition, health and aging, 28(3) (3), 100175 - 100175, English, International magazineScientific journal
- PURPOSE: To investigate individual and environmental vaccination-related factors among the older adults in Japan, using administrative data. METHODS: We conducted a cohort study and included people who reached the relevant age (≥65 years) for routine pneumococcal vaccination of older adults between April 2015 and March 2020. Monthly data of residents in the two municipalities from April 2014 to March 2020 and vaccination records from April 2015 to March 2020 were used. We defined five cohorts according to the year in which routine vaccinations were available. Each cohort was followed for a total of two years, with the first year being the "baseline period" and second year being the "vaccine follow-up period." Pneumococcal vaccination data was extracted from vaccination records at "first dose." Age, sex, socioeconomic status, comorbidities, hospital visit history, hospitalization history, Specific Health Check-ups participation, and information on contracted hospitals for pneumococcal vaccination were used as covariates. A multivariate logistic regression model was used to investigate the relationship between pneumococcal vaccination and vaccination-related factors. Odds ratios (OR) and 95 % confidence intervals (95 % CI) were calculated. RESULTS: Analysis included 17,991 patients. Vaccination coverage was 33.6 % for all subjects. Multivariate analysis found the following as significant vaccination-related factors: female (OR: 1.18, 95 % CI: 1.11-1.26), not low income (1.76, 1.17-2.76), hospital visits: ≥once/month (1.27, 1.19-1.35), and Specific Health Check-ups participation (2.10, 1.95-2.27). No significant results were found for hospitals that contracted pneumococcal vaccination. CONCLUSIONS: Individual factors, such as sex and Specific Health Check-ups participation, were found to be important factors affecting pneumococcal vaccination among older adults in Japan. Environmental factors, such as the characteristics of residential areas, should be evaluated in further investigations.Jan. 2024, Vaccine, 42(2) (2), 239 - 245, English, International magazineScientific journal
- Background and Objectives: Bone metastasis cancer boards (BMCBs) focusing on the management of bone metastases have been gathering much attention. However, the association of BMCBs with spinal surgery in patients with spinal metastases remains unclear. In this retrospective single-center observational study, we aimed to clarify the effect of a BMCB on spinal metastasis treatment. Materials and Methods: We reviewed consecutive cases of posterior decompression and/or instrumentation surgery for metastatic spinal tumors from 2008 to 2019. The BMCB involved a team of specialists in orthopedics, rehabilitation medicine, radiation oncology, radiology, palliative supportive care, oncology, and hematology. We compared demographics, eastern cooperative oncology group performance status (ECOGPS), Barthel index (BI), number of overall versus emergency surgeries, and primary tumors between patients before (2008-2012) and after (2013-2019) BMCB establishment. Results: A total of 226 patients including 33 patients before BMCB started were enrolled; lung cancer was the most common primary tumor. After BMCB establishment, the mean patient age was 5 years older (p = 0.028), the mean operating time was 34 min shorter (p = 0.025), the mean hospital stay was 34.5 days shorter (p < 0.001), and the mean BI before surgery was 12 points higher (p = 0.049) than before. Moreover, the mean number of surgeries per year increased more than fourfold to 27.6 per year (p < 0.01) and emergency surgery rates decreased from 48.5% to 29.0% (p = 0.041). Patients with an unknown primary tumor before surgery decreased from 24.2% to 9.3% (p = 0.033). Postoperative deterioration rates from 1 to 6 months after surgery of ECOGPS and BI after BMCB started were lower than before (p = 0.045 and p = 0.027, respectively). Conclusion: The BMCB decreased the emergency surgery and unknown primary tumor rate despite an increase in the overall number of spinal surgeries. The BMCB also contributed to shorter operation times, shorter hospital stays, and lower postoperative deterioration rates of ECOGPS and BI.Nov. 2023, Medicina (Kaunas, Lithuania), 59(12) (12), English, International magazineScientific journal
- 日本公衆衛生学会, Oct. 2023, 日本公衆衛生学会総会抄録集, 82回, 302 - 302, JapaneseCOVID-19流行の乳幼児定期予防接種完了への影響 VENUS Study
- BACKGROUND: Several studies have investigated post-extraction bleeding in patients on antithrombotic therapy, but most included a small sample size. OBJECTIVE: This study aimed to analyse post-extraction bleeding in patients on antithrombotic therapy using data from a large database. MATERIALS AND METHODS: Claims data of National Health Insurance and Late-Stage Elderly Healthcare System enrollees who underwent tooth extraction between October 2014 and March 2019 (n = 107 767) in a large multiregional cohort study (Longevity Improvement and Fair Evidence study) were included. Antithrombotic therapy was determined based on the drug codes used at the time of tooth extraction (classified into six groups: no antithrombotic, single antiplatelet, dual antiplatelet, Direct Oral Anticoagulant, warfarin and combined antiplatelet and anticoagulant therapies). The outcome was defined as the presence of "post-extraction bleeding" as a receipt disease name in the same month as tooth extraction. To examine the association between antithrombotic therapy and post-extraction bleeding in detail, multiple logistic regression analysis was performed with post-extraction bleeding as the objective variable; each antithrombotic therapy as the explanatory variable; and age, sex and comorbidities as adjustment variables. RESULTS: Antithrombotic therapy was administered in 14 343 patients (13.3%), and post-extraction bleeding was observed in 419 patients (0.4%). The rate of post-extraction bleeding was significantly lower in the no antithrombotic therapy and single antiplatelet groups than that in the other groups (odds ratio: 2.00-9.02). CONCLUSION: The frequency of post-extraction bleeding is high in patients on anticoagulation or dual antithrombotic therapy. Therefore, careful preparation before extraction is necessary in these patients.Jul. 2023, Gerodontology, English, International magazine[Refereed]Scientific journal
- The number of advanced-age patients with spinal metastases is rising. This study was performed to clarify the characteristics and surgical outcomes of spinal metastases in advanced-age patients. We prospectively analyzed 216 patients with spinal metastases from 2015 to 2020 and divided them into three age groups: <70 years (n = 119), 70-79 years (n = 73), and ≥80 years (n = 24). Although there were no significant intergroup differences in preoperative characteristics and surgery-related factors except for age, patients aged ≥80 years tended to have a worse performance status (PS), Barthel index, and EuroQol-5 dimension (EQ-5D) before and after surgery than the other two groups. Although the median PS, mean Barthel index and mean EQ-5D greatly improved postoperatively in each group, the median PS and mean Barthel index at 6 months and the mean EQ-5D at 1 month postoperatively were significantly poorer in the ≥80-year group than the 70-79-year group. The rates of postoperative complications and re-deterioration of the EQ-5D were significantly higher in the oldest group than in the other two groups. Although surgery for spinal metastases improved the PS, Barthel index, and EQ-5D regardless of age, clinicians should be aware of the poorer outcomes and higher complication rates in advanced-age patients.Jul. 2023, Journal of clinical medicine, 12(14) (14), English, International magazine[Refereed]Scientific journal
- (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1429 - S1429, Japanese
- (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1352 - S1352, Japanese
- (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1382 - S1382, Japanese
- (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1435 - S1435, Japanese
- (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1439 - S1439, Japanese
- (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1440 - S1440, Japanese
- (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1429 - S1429, Japanese
- BACKGROUND: Older adults are more likely to experience loneliness than younger people. Moreover, greater loneliness in older adults is associated with poor mental health and increased risk of cardiovascular disease and mortality. Physical activity is an effective intervention for reducing loneliness among older adults. Among physical activities, walking is suitable for older adults, because it is easy and safe to incorporate into daily life. We hypothesized that the association between walking and loneliness depends on the presence of others and the number of people present. The aim of this study is to investigate the association between the context of walking (the number of walkers) and loneliness among community-dwelling older adults. METHODS: This cross-sectional study included 173 community-dwelling older adults aged 65 or older. Context of walking was classified as non-walking, walking alone (days of walking alone > days of walking with someone), and walking with someone (days of walking alone ≤ days of walking with someone). Loneliness was measured using the Japanese version of the University of California Los Angeles Loneliness Scale. A linear regression model was used to investigate the relationship between context of walking and loneliness, adjusted for age, sex, living situation, social participation, and physical activity excluding walking. RESULTS: Data from 171 community-dwelling older adults (mean age = 78.0 years, 59.6% women) were analyzed. After adjustment, walking with someone was associated with lower loneliness than non-walking (adjusted β: -0.51, 95% confidence interval: -1.00, -0.01). CONCLUSIONS: The study's findings suggest that walking with a companion may effectively prevent or reduce loneliness among older adults.May 2023, BMC geriatrics, 23(1) (1), 326 - 326, English, International magazine[Refereed]Scientific journal
- AIM: To investigate the association between locomotive syndrome and anemia among community-dwelling older adults. METHODS: This cross-sectional study was conducted at specific health checkup centers in Japan between 2019 and 2020. We sent a questionnaire to older adults aged ≥65 years who participated in health checkups. A total of 2507 community-dwelling older adults were included in this study (mean age = 72.3 years, 51.4% women). Locomotive syndrome was measured using a 25-question Geriatric Locomotive Function Scale with a score range of 0-100, and was defined as ≥16 points. Anemia was defined using World Health Organization criteria, as a hemoglobin concentration of <13.0 g/dL in men and <12.0 g/dL in women. Logistic regression analyses were performed to investigate the association between locomotive syndrome and anemia, adjusted for age, sex, body mass index, depression symptoms, self-reported comorbidities (cancer, rheumatoid arthritis, knee osteoarthritis, fractures, and spinal disease), hypertension, and renal function. RESULTS: Of all the participants, 11.6% had locomotive syndrome and 12.8% had anemia. Even after adjustment, a relationship between locomotive syndrome and anemia was observed (adjusted odds ratio = 1.9, 95% confidence interval = 1.3-2.7). CONCLUSIONS: Community-dwelling older adults with anemia had a significantly higher prevalence of locomotive syndrome than those without. This finding suggests that older adults with anemia are at risk of locomotive syndrome, and appropriate measures should be taken for prevention. Geriatr Gerontol Int 2023; ••: ••-••.May 2023, Geriatrics & gerontology international, 23(6) (6), 426 - 429, English, Domestic magazine[Refereed]Scientific journal
- (公社)日本リハビリテーション医学会, May 2023, The Japanese Journal of Rehabilitation Medicine, 60(特別号) (特別号), 1 - 4, Japanese骨転移キャンサーボードが骨転移患者のQOLに及ぼす影響に関する検討
- BACKGROUNDS: We aimed to assess whether the U.S. developed claimed-based frailty index (CFI) can be implemented in Japanese older adults using claim data. METHODS: We used the monthly claims data and certification of long-term care (LTC) insurance data of residents from 12 municipalities from April 2014 to March 2019. The 12 months from first recording was defined as the "baseline period," and the time thereafter as "follow-up period". Participants aged ≥65 years and those with no certified LTC insurance or who died at baseline were included. New certification of LTC insurance and all-cause mortality during the follow-up period were defined as outcome events. CFI categorization consisted of three steps including: 1) using 12 months deficit-accumulation approach that assigned different weights to each of the 52 items; 2) the accumulated score to derive the CFI; and 3) categorizing the CFI as "robust" (<0.15), "prefrail" (0.15-0.24), and "frail" (≥0.25). Kaplan-Meier survival curves and Cox proportional hazard models were used to determine the association between CFI and outcomes. Hazard ratios (HR) and 95% confidence intervals (95%CI) were calculated. RESULTS: The participants were 519,941 in total. After adjusting for covariates, the severe CFI category had a high risk of certification of LTC insurance (prefrail, HR: 1.33, 95%CI:1.27-1.39; frail, HR: 1.60, 95%CI: 1.53-1.68) and all-cause mortality (prefrail, HR: 1.44, 95%CI: 1.29-1.60; frail, HR: 1.84, 95%CI: 1.66-2.05). CONCLUSIONS: This study suggests that CFI can be implemented in Japanese claims data by predicting the certification of LTC insurance and mortality.Mar. 2023, Journal of epidemiology, English, Domestic magazine[Refereed]Scientific journal
- (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S957 - S957, Japanese
- PURPOSE: Physical activity is important to improve recovery following surgery. This study investigated the impact of physical activity on the development of pneumonia after radical esophagectomy in patients with thoracic esophageal cancer in the subacute phase from postoperative day 11 to hospital discharge. METHODS: This retrospective cohort study included 83 patients who underwent radical esophagectomy for esophageal cancer between 2016 and 2022. Physical activity was measured using an activity tracker, and the average number of steps between postoperative days 8 and 10 was examined. The primary outcome was pneumonia (Clavien-Dindo classification 2 or higher) developing between postoperative day 11 and hospital discharge. We used the receiver operating characteristic (ROC) curve analysis to calculate the optimal cutoff value of physical activity that can predict the development of pneumonia and define low physical activity. We used logistic regression analysis to investigate the impact of low physical activity on postoperative pneumonia. RESULTS: Pneumonia developed in 10 patients (12.0%) during the observation period. The optimal cutoff value of physical activity for predicting pneumonia was 1494 steps per day (sensitivity: 60.0%, specificity: 89.0%, area under the curve: 0.743). In multivariate analysis, low physical activity was an independent predictor of incident pneumonia [odds ratio: 12.10, 95% confidence interval: 2.21-65.90, p = 0.004], with adjustment for age, gastric tube reconstruction route, and postoperative recurrent nerve palsy. CONCLUSIONS: Physical activity following radical esophagectomy in patients with thoracic esophageal cancer was an independent predictor of the development of pneumonia in the subacute phase after radical esophagectomy.Feb. 2023, European journal of oncology nursing : the official journal of European Oncology Nursing Society, 62, 102270 - 102270, English, International magazine[Refereed]Scientific journal
- 2023, Journal of Nutrition, Health and AgingScientific journal
- (一社)中部日本整形外科災害外科学会, Jan. 2023, 中部日本整形外科災害外科学会雑誌, 66(1) (1), 101 - 102, Japanese
- INTRODUCTION: The introduction of tyrosine kinase inhibitors has revolutionized treatment strategies for metastatic renal cell carcinoma (RCC) and has improved survival rates. The number of patients with bone metastases from RCC requiring surgery will increase as survival rates improve. However, there is insufficient evidence to standardize the treatment of bone metastases after the introduction of targeted therapy for metastatic RCC. We aimed to determine the outcomes of palliative surgical treatment of bone metastases in the extremities of patients with metastatic RCC. MATERIALS AND METHODS: We retrospectively reviewed 26 lesions from 17 patients who underwent surgery for extremity and acetabular bone metastases and were treated with targeted therapies for advanced RCC between 2008 and 2020. The median follow-up duration was 19 months (range, 4-76). We assessed the patients' activities of daily living, quality of life, and pain and analyzed their postoperative values relative to preoperative values. Postoperative overall survival (OS), local progression-free survival (LPFS), and the factors affecting them were evaluated using the Kaplan-Meier method and log-rank test. RESULTS: The 5-year OS and LPFS rates were 39.5% and 65.6%, respectively. The factors affecting OS were sex, Katagiri score, visceral metastases, and preoperative targeted therapy, while the factors affecting LPFS were pathologic fractures and surgical technique. CONCLUSION: In this study, the postoperative outcomes of palliative surgery for bone metastases from metastatic RCC were good. We suggest that systemic treatment should be prioritized over local control for advanced bone metastasis in RCC and surgery before pathological fracture should be performed for local control.Last, Nov. 2022, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 49(5) (5), 928 - 933, English, International magazine[Refereed]Scientific journal
- BACKGROUND: This randomised phase II/III trial aimed to determine whether perioperative chemotherapy with gemcitabine plus docetaxel (GD) is non-inferior to the standard Adriamycin plus ifosfamide (AI) in terms of overall survival (OS) in patients with soft tissue sarcoma (STS). METHODS: Patients with localised high-risk STS in the extremities or trunk were randomised to receive AI or GD. The treatments were repeated for three preoperative and two postoperative courses. The primary endpoint was OS. RESULTS: Among 143 enrolled patients who received AI (70 patients) compared to GD (73 patients), the estimated 3-year OS was 91.4% for AI and 79.2% for GD (hazard ratio 2.55, 95% confidence interval: 0.80-8.14, P = 0.78), exceeding the prespecified non-inferiority margin in the second interim analysis. The estimated 3-year progression-free survival was 79.1% for AI and 59.1% for GD. The most common Grade 3-4 adverse events in the preoperative period were neutropenia (88.4%), anaemia (49.3%), and febrile neutropenia (36.2%) for AI and neutropenia (79.5%) and febrile neutropenia (17.8%) for GD. CONCLUSIONS: Although GD had relatively mild toxicity, the regimen-as administered in this study-should not be considered a standard treatment of perioperative chemotherapy for high-risk STS in the extremities and trunk. CLINICAL TRIAL REGISTRATION: jRCTs031180003.Nov. 2022, British journal of cancer, 127(8) (8), 1487 - 1496, English, International magazine[Refereed]Scientific journal
- Ewing sarcoma (ES) is an aggressive primary malignant bone tumor that predominantly affects children and young adults. Multimodal treatment approaches have markedly improved the survival of patients with localized ES. However, local recurrence and distant metastasis following curative therapies remain a main concern for patients with ES. Recent studies have suggested that slow‑cycling cells (SCCs) are associated with tumor progression, local recurrence and distant metastasis in various types of cancers. According to the results of these studies, it was hypothesized that SCCs may play a critical role in tumor progression, chemoresistance and local/distal recurrence in patients with ES. The present study applied a label‑retaining system using carboxyfluorescein diacetate succinimidyl ester (CFSE) to identify and isolate SCCs in ES cell lines. In addition, the properties of SCCs, including sphere formation ability, cell cycle distribution and chemoresistance, in comparison with non‑SCCs were investigated. RNA sequencing also revealed several upregulated genes in SCCs as compared with non‑SCCs; the identified genes not only inhibited cell cycle progression, but also promoted the malignant properties of SCCs. On the whole, the present study successfully identified SCCs in ES cells through a label‑retaining system using CFSE. Moreover, to the best of our knowledge, the present study is the first to describe the characteristic properties of SCCs in ES. The findings of this study, if confirmed, may prove to be useful in elucidating the underlying molecular mechanisms and identifying effective therapeutic targets for ES.Last, Nov. 2022, International journal of oncology, 61(5) (5), English, International magazine[Refereed]Scientific journal
- BACKGROUND: Gait-balance disturbances are core symptoms of idiopathic normal pressure hydrocephalus (iNPH). However, the rehabilitation effects of cerebrospinal fluid (CSF) shunting along with other treatment or no further treatment (natural course [NC]) for iNPH are unknown. OBJECTIVES: This study evaluated whether dynamic equilibrium gait training (DEGT) can improve gait-balance functions after CSF shunting of patients with iNPH compared to standard exercise (SE) and NC. Furthermore, it investigated the incidence of falls. METHODS: A total of 70 patients with iNPH who underwent CSF shunting were randomly assigned to 6 weeks of DEGT (n = 23), 6 weeks of SE (n = 23), or NC (n = 24). Evaluation was performed at baseline (preoperatively) and at 1 week, 7 weeks (postintervention), and 6 months postoperatively (follow-up). Outcomes were measured using the functional gait assessment (FGA), 10-m walk test, timed up-and-go test, life-space assessment (LSA), and fall incidence. RESULTS: A total of 65 participants completed the study. During the intention-to-treat analysis, the DEGT group demonstrated significant recovery of gait-balance functions according to only the FGA at postintervention and follow-up compared to the SE and NC groups; however, recovery of the SE group did not differ from that of the NC group. The DEGT group had a significantly lower fall incidence than the other groups at follow-up. Significantly better LSA results were observed for all groups at follow-up compared to baseline; however, no difference in LSA results were observed between groups. CONCLUSIONS: DEGT in addtion to CSF shunting can facilitate the recovery of gait-balance function and reduce the fall incidence of iNPH patients.Springer Science and Business Media LLC, Sep. 2022, Journal of Neurology, English, International magazine[Refereed]Scientific journal
- BACKGROUND: This study aimed to investigate whether dynamic gait stability differs between idiopathic normal-pressure hydrocephalus with high- and low-fall-risk. METHODS: Participants comprised 40 idiopathic normal-pressure hydrocephalus patients and 23 healthy-controls. Idiopathic normal-pressure hydrocephalus patients were divided into those with high-fall-risk (n = 20) and low-fall-risk (n = 20) groups using the cut-off score of ≤14/30 for fall-risk on the Functional Gait Assessment. Dynamic stability during gait was assessed by three-dimensional motion analysis. Dynamic stability was defined as the ability to maintain an extrapolated center of mass within the base of support at heel contact, with the distance between the two defined as the margin of stability. Conscious motor control was assessed by the Movement-Specific Reinvestment Scale. FINDINGS: Anteroposterior and mediolateral margin of stabilities were significantly larger in both idiopathic normal-pressure hydrocephalus groups than in healthy-controls. The mediolateral margin of stability was significantly higher in the high-fall-risk group than in the low-fall-risk group; whereas, the anteroposterior margin of stability did not differ between idiopathic normal-pressure hydrocephalus groups. The Movement-Specific Reinvestment Scale was significantly higher in the high-fall-risk group than in the low-fall-risk group. INTERPRETATION: Idiopathic normal-pressure hydrocephalus patients with have high forward and lateral dynamic stability during gait regardless of their fall-risk. In particular, idiopathic normal-pressure hydrocephalus patients with high-fall-risk may consciously maintain lateral dynamic stability to a greater extent than those with low-fall-risk. These findings highlight a conscious motor control component in the pathological gait of idiopathic normal-pressure hydrocephalus, and provide clues for rehabilitation and fall prevention strategies in idiopathic normal-pressure hydrocephalus patients.Sep. 2022, Clinical biomechanics (Bristol, Avon), 99, 105757 - 105757, English, International magazine[Refereed]Scientific journal
- This study aimed to retrospectively analyze the clinical outcomes of patients with pelvic and retroperitoneal bone and soft tissue sarcoma (BSTS). Overall, 187 patients with BSTS in the pelvis and retroperitoneal region treated at 19 specialized sarcoma centers in Japan were included. The prognostic factors related to overall survival (OS), local control (LC), and progression-free survival (PFS) were evaluated. The 3-year OS and LC rates in the 187 patients were 71.7% and 79.1%, respectively. The 3-year PFS in 166 patients without any distant metastases at the time of primary tumor diagnosis was 48.6%. Osteosarcoma showed significantly worse OS and PFS than other sarcomas of the pelvis and retroperitoneum. In the univariate analyses, larger primary tumor size, soft tissue tumor, distant metastasis at the time of primary tumor diagnosis, P2 location, chemotherapy, and osteosarcoma were poor prognostic factors correlated with OS. Larger primary tumor size, higher age, soft tissue tumor, chemotherapy, and osteosarcoma were poor prognostic factors correlated with PFS in patients without any metastasis at the initial presentation. Larger primary tumor size was the only poor prognostic factor correlation with LC. This study has clarified the epidemiology and prognosis of patients with pelvic and retroperitoneal BSTS in Japan.Last, MDPI AG, Jun. 2022, Cancers, 14(12) (12), 3023 - 3023, English, International magazine[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, May 2022, 中部日本整形外科災害外科学会雑誌, 65(3) (3), 403 - 404, JapaneseScientific journal
- (一社)日本理学療法学会連合, Apr. 2022, 理学療法学, 49(2) (2), 155 - 161, Japanese
- 金原出版(株), Apr. 2022, 臨床放射線, 67(4) (4), 365 - 371, Japanese
- Apr. 2022, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 52(9) (9), 1021 - 1028, English, International magazine[Refereed]Scientific journal
- Purpose: Soft tissue sarcomas (STSs) constitute a group of rare, heterogeneous tumors representing approximately 1% of all cancers. Owing to the rarity and pathological diversity of the disease, unplanned excision (UE) has often been performed for STS, resulting in an unfavorable prognosis. This study aimed to clarify clinical outcomes and prognostic factors in STS patients who underwent UE. Patients and Methods: In a retrospective review of the medical records of patients with STS who underwent surgery at our institution between 1999 and 2015, patients were enrolled to either a UE group or a planned excision (PE) group. An analysis was then conducted to identify factors associated with prognosis after UE. Results: Of 134 patients undergoing surgery for STS, 110 were enrolled to the PE group and 24 to the UE group. The median size of the primary tumor was significantly smaller, and more lesions were located in the superficial layer in the UE group than in the PE group. In addition, plastic reconstruction after additional radical resection was required significantly more often in the UE group than in the PE group. No significant difference in overall survival, local recurrence-free survival, or disease-free survival (DFS) between the UE and PE groups was observed; however, metastasis-free survival was significantly better in the UE group. In the UE group, poorer DFS was associated with older age (≥61 years) and a larger primary tumor (≥2.9 cm). Conclusion: A prognosis similar to that in patients undergoing PE could be achieved by appropriate additional surgeries in patients initially undergoing UE. However, UE for STS should be avoided, especially in older patients and those with a larger primary tumor.Last, 2022, Cancer management and research, 14, 1815 - 1824, English, International magazine[Refereed]Scientific journal
- Objectives: Balance in the mediolateral direction is usually maintained in patients with early-stage Parkinson's disease (PD), but not in moderate-stage PD as revealed by the Tandem Gait Test. Although mediolateral postural control in PD patients remains controversial, previous studies have shown that the Tandem Gait Test may predict the risk of future falls in patients with PD. This study aimed to clarify postural control differences among PD patients with and without mediolateral balance impairments (MLBI: mediolateral balance impairments, nMLBI: non-mediolateral balance impairments, respectively) and healthy controls (HCs). Methods: We recruited 40 PD patients and 20 HCs. According to the Tandem Gait Test score, PD patients were divided into MLBI and nMLBI groups. Primary outcome measures were the ambulatory movement trajectory amplitude of the center of mass and its coefficient of variation (CV) during gait. Results: Mediolateral movement trajectory amplitudes and CV were not significantly different between the nMLBI group and HCs, whereas the mediolateral movement trajectory amplitude in the MLBI group was significantly higher than that in the nMLBI group. Moreover, the CV of the mediolateral movement trajectory amplitude in the MLBI group was significantly lower than that in the nMLBI group. The mediolateral movement trajectory amplitude was significantly correlated with the fall score. Conclusions: The current results suggest that PD patients with mediolateral balance impairments showed mediolateral postural sway during gait compared with PD patients without mediolateral balance impairments. It is necessary to focus on the instabilities in the mediolateral direction to avoid falls in PD patients.Corresponding, 2022, Progress in rehabilitation medicine, 7, 20220048 - 20220048, English, Domestic magazine[Refereed]Scientific journal
- 2022, SAGE open medical case reports, 10, 2050313X211067917, English, International magazine[Refereed]Scientific journal
- Dec. 2021, Journal of Biomechanics, 129[Refereed]Scientific journal
- Osteolytic bone metastasis leads to skeletal‑related events, resulting in a decline in the patient activities and survival; therefore, it is important to understand the mechanism underlying bone metastasis. Recent studies have suggested that microRNAs (miRNAs or miRs) are involved in osteoclast differentiation and/or osteolytic bone metastasis; however, the roles of miRNAs have not been elucidated. In the present study, the roles of miRNAs in bone destruction caused by breast cancer metastasis were investigated in vitro and in vivo. miR‑16, miR‑133a and miR‑223 were transfected into a human breast cancer cell line, MDA‑MB‑231. The expression of osteolytic factors in conditioned medium (miR‑CM) collected from the culture of transfected cells was assessed. To evaluate the effects of miRNAs on osteoclast differentiation and activities, tartrate‑resistant acid phosphatase (TRAP) staining and bone resorptive assays were performed in osteoclasts following miR‑CM treatment. To create in vivo bone metastasis models for histological and morphometric evaluation, miRNA‑transfected MDA‑MB‑231 cells were transplanted into the proximal tibia of nude mice. Expression of osteolytic factors, including receptor activator for nuclear factor‑κB ligand (RANKL), interleukin (IL)‑1β, IL‑6, parathyroid hormone‑related protein (PTHrP), and tumor necrosis factor (TNF), was increased in miR‑16‑CM, whereas it was decreased in both miR‑133a‑CM and miR‑223‑CM. TRAP staining and bone resorptive assays revealed that osteoclast function and activities were promoted by miR‑16‑CM treatment, whereas they were suppressed by miR‑133a‑CM and miR‑223‑CM. Consistent with in vitro findings, in vivo experiments revealed that the overexpression of miR‑16 increased osteoclast activities and bone destruction in MDA‑MB‑231 cells, whereas the opposite results were observed in both miR‑133a‑ and miR‑223‑transfected MDA‑MB‑231 cells. Our results indicated that miR‑16 promoted osteoclast activities and bone destruction caused by breast cancer metastasis in the bone microenvironment, whereas miR‑133a and miR‑223 suppressed them. These miRNAs could be potential biomarkers and therapeutic targets for breast cancer bone metastasis.Last, Nov. 2021, International journal of oncology, 59(5) (5), English, International magazine[Refereed]Scientific journal
- Wiley, Oct. 2021, Acta Neurologica Scandinavica, 145(2) (2), 215 - 222[Refereed]Scientific journal
- (株)医学書院, Oct. 2021, 臨床整形外科, 56(10) (10), 1231 - 1237, Japanese
- (株)南江堂, Oct. 2021, 別冊整形外科, (80) (80), 21 - 26, Japanese
- Springer, Aug. 2021, Calcified Tissue International, 109(2) (2), 230, EnglishScientific journal
- Current treatment options for osteoporosis primarily involve pharmacotherapies, but they are often accompanied by undesirable side effects. Utilization of mechanical stress which can noninvasively induce bone formation has been suggested as an alternative to conventional treatments. Here, we examined the efficacy of mechanical stress induced by electrical stimulation, radial extracorporeal shock waves, and ultrasound for estrogen-deficient osteoporosis. Female Wistar rats were divided into following five groups: sham-operated group, untreated after ovariectomy, and treated with electrical stimulation, radial extracorporeal shock wave, or ultrasound starting at 8 weeks after ovariectomy for 4 weeks. Trabecular bone architecture of the femur was assessed by micro-CT and its biomechanical properties were obtained by mechanical testing. The femurs were further evaluated by histochemical, immunohistochemical, and real-time PCR analyses. Radial extracorporeal shock wave and ultrasound treatment improved trabecular bone microarchitecture and bone strength in osteoporotic rats, but not electrical stimulation. The shock wave decreased osteoclast activity and RANKL expression. The exposure of ultrasound increased osteoblast activity and β-catenin-positive cells, and they decreased sclerostin-positive osteocytes. These findings suggest that mechanical stress induced by radial extracorporeal shock wave and ultrasound can improve estrogen-deficient bone loss and bone fragility through promoted bone formation or attenuated bone resorption.Aug. 2021, Calcified tissue international, 109(2) (2), 215 - 229, English, International magazine[Refereed]Scientific journal
- Fractures associated with osteoporosis are a major public health concern. Current treatments for fractures are limited to surgery or fixation, leading to long-term bedrest, which is linked to increased mortality. Alternatively, utilization of physical agents has been suggested as a promising therapeutic approach for fractures. Here, we examined the effects of ultrasound, radial extracorporeal shock waves, and electrical stimulation on normal or osteoporotic fracture healing. Femoral bone defects were created in normal or ovariectomized rats. Rats were divided into four groups: untreated, and treated with ultrasound, shock waves, or electrical stimulation after surgery. Samples were collected at 2 or 4 weeks after surgery, and the healing process was evaluated with micro-CT, histological, and immunohistochemical analyses. Ultrasound at intensities of 0.5 and 1.0 W/cm2 , but not 0.05 W/cm2 , accelerated new bone formation. Shock wave exposure also increased newly formed bone, but formed abnormal periosteal callus around the defect site. Conversely, electrical stimulation did not affect the healing process. Ultrasound exposure increased osteoblast activity and cell proliferation and decreased sclerostin-positive osteocytes. We demonstrated that higher-intensity ultrasound and radial extracorporeal shock waves accelerate fracture healing, but shock wave treatment may increase the risk of periosteal callus formation.Aug. 2021, Annals of the New York Academy of Sciences, 1497(1) (1), 3 - 14, English, International magazine[Refereed]Scientific journal
- OBJECTIVES: We evaluated the perceived and actual changes in gait and balance function immediately after cerebrospinal fluid (CSF) shunting in patients with idiopathic normal pressure hydrocephalus (iNPH), including those with mild cases. MATERIALS AND METHODS: Ninety-nine iNPH patients were assessed using the timed Up and Go (TUG) and Functional Gait Assessment (FGA) before and 1-week after CSF shunting and their perceived changes were assessed on a Global Rate of Change (GRC) scale. Minimal clinically important differences (MCIDs) were calculated using a receiver operating characteristic (ROC) curve method using GRC scores. RESULTS: In all patients (n = 99), the TUG value postoperatively was significantly faster than the preoperative value (difference; 3.1 ± 4.6 s, p < 0.001), and the postoperative FGA score was significantly better than the preoperative score (difference; 3.8 ± 3.3 points, p < 0.001). In the TUG <15 s group (n = 51), the postoperative FGA score was significantly improved (difference; 3.3 ± 2.9 points, p < 0.001), whereas the TUG value was only slightly improved (difference; 0.6 ± 1.6 s, p = 0.008). The ROC curve MCIDs of GRC ≥2 points, which is the recommended level of improvement, were 1.7 s (16.5%) for the TUG and 4 points (20.0%) for the FGA in all patients (n = 99) and the TUG <15 s group (n = 51). CONCLUSIONS: FGA can be used to confirm treatment effects, including perceived and actual changes after CSF shunting, in patients with mild iNPH. Our results can help clinicians to determine the clinical significance of improvements in gait and balance function immediately after CSF shunting in individual patients with iNPH.Jul. 2021, Acta neurologica Scandinavica, 144(1) (1), 21 - 28, English, International magazine[Refereed]Scientific journal
- Background: Skeletal related events due to metastatic bone tumors markedly affect the activities of daily living (ADL) and quality of life (QOL) in cancer patients. We focused on multidisciplinary therapy for metastatic bone tumors. This study aimed to evaluate the outcomes of surgical treatment for metastatic bone tumors in the extremities. Methods: We retrospectively reviewed 114 patients who underwent surgical treatment for metastatic bone tumors of the extremities between 2008 and 2019 and 69 patients were reassessed for more than 6 months after surgery. The most common primary tumor was renal, followed by lung, thyroid, and breast cancers. We assessed 69 patients' performance status (PS), Barthel Index (BI) for ADL, EuroQol 5 Dimensions (EQ-5D) for QOL, and numerical rating scale (NRS) for pain and analyzed these postoperative values relative to preoperative values using Friedman's test. The postoperative overall survival and the prognostic factors were evaluated using the Kaplan-Meier method, the log-rank test and Cox proportional hazards analysis. Results: The 1-year overall survival rate was 59%, and the median survival time after surgery was 20 months. Primary tumor, visceral metastasis, and surgical procedure were risk factors correlated with overall survival. PS, BI, EQ-5D, and NRS improved at 3 months after surgery and these improvements were maintained for 6 months after surgery regardless of the surgical procedure. Conclusions: The significant factors affecting survival after surgical treatment for bone metastases included the primary tumor, presence of visceral metastases, and internal fixation without tumor resection or curettage. Surgical treatment for metastatic bone tumors effectively reduced pain and improved PS, ADL, and QOL postoperatively after 3 months.Apr. 2021, Journal of bone oncology, 27, 100352 - 100352, English, International magazine[Refereed]Scientific journal
- Synovial sarcoma is a rare tumor requiring new treatment methods. A 46-year-old woman with primary monophasic synovial sarcoma in the left thigh involving the sciatic nerve, declining surgery because of potential dysfunction of the affected limbs, received two courses of BNCT. The tumor thus reduced was completely resected with no subsequent recurrence. The patient is now able to walk unassisted, and no local recurrence has been observed, demonstrating the applicability of BNCT as adjuvant therapy for synovial sarcoma. Further study and analysis with more experience accumulation are needed to confirm the real impact of BNCT efficacy for its application to synovial sarcoma.Mar. 2021, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 169, 109407 - 109407, English, International magazine[Refereed]Scientific journal
- BACKGROUND/AIM: This study aimed to evaluate the association of clinical characteristics with treatment outcomes to ascertain the appropriate treatment options for soft tissue sarcomas (STS) patients with brain metastasis (BM). PATIENTS AND METHODS: Medical records of STS patients with BM who were treated in our institutions were retrospectively reviewed, and analyzed to identify the factors associated with post-BM survival. RESULTS: Among the 509 STS patients, BM occurred in five patients (0.98%). The median survival after BM was 1.5 months. Histological subtypes of the primary lesions in the five BM patients were: two synovial sarcomas, one myxoid liposarcoma, one alveolar soft part sarcoma, and one rhabdomyosarcoma. Among the five BM patients, the post-BM survival of two patients, who underwent surgery and postoperative radiotherapy, was longer than that of the other patients (p<0.01). CONCLUSION: Combined surgery and postoperative radiotherapy effectively managed symptoms and prolonged survival in STS patients with BM.Feb. 2021, Anticancer research, 41(2) (2), 1027 - 1034, English, International magazine[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Jan. 2021, 中部日本整形外科災害外科学会雑誌, 64(1) (1), 73 - 74, Japanese
- Chondrolipoma is, based on the limited case reports available, an extremely rare histological variant of lipoma with the proliferation of mature adipocytes containing an area of true hyaline cartilage. Chondrolipoma is characterized by adult onset and is often identified in the breast, pharynx and tongue. The current study presents a case of chondrolipoma of the finger in an 11 year-old girl. Physical examination indicated a well-defined elastic soft mass, measuring 2.5x2 cm, on the dorsal aspect of the proximal phalanx of the left middle finger. Magnetic resonance imaging (MRI) revealed a well-circumscribed lesion with heterogeneous signal intensity. On T1- and T2-weighted images, the lesion indicated a predominantly marked hyperintense signal containing linear hypointense regions, and on fat-suppressed short-tau inversion recovery sequences, the lesion indicated a predominant hypointensity, with linear regions displaying hyperintensity. Marginal excision of the tumor was performed. Histologically, the major component of the tumor was mature adipose tissue containing a limited area of mature hyaline cartilage matrix, without lipoblasts or malignancy. The postoperative course of the patient was excellent, with no local recurrence three years after surgery. To the best of our knowledge, the current study outlines the first pediatric case of chondrolipoma arising in the finger.Jan. 2021, Molecular and clinical oncology, 14(1) (1), 2 - 2, English, International magazine[Refereed]Scientific journal
- INTRODUCTION: Diabetes mellitus (DM) negatively affects fracture repair by inhibiting endochondral ossification, chondrogenesis, callus formation, and angiogenesis. We previously reported that transcutaneous CO2 application accelerates fracture repair by promoting endochondral ossification and angiogenesis. The present study aimed to determine whether CO2 treatment would promote fracture repair in cases with type I DM. RESEARCH DESIGN AND METHODS: A closed femoral shaft fracture was induced in female rats with streptozotocin-induced type I DM. CO2 treatment was performed five times a week for the CO2 group. Sham treatment, where CO2 was replaced with air, was performed for the control group. Radiographic, histologic, genetic, and biomechanical measurements were taken at several time points. RESULTS: Radiographic assessment demonstrated that fracture repair was induced in the CO2 group. Histologically, accelerated endochondral ossification and capillary formation were observed in the CO2 group. Immunohistochemical assessment indicated that early postfracture proliferation of chondrocytes in callus was enhanced in the CO2 group. Genetic assessment results suggested that cartilage and bone formation, angiogenesis, and vasodilation were upregulated in the CO2 group. Biomechanical assessment revealed enhanced mechanical strength in the CO2 group. CONCLUSIONS: Our findings suggest that CO2 treatment accelerates fracture repair in type I DM rats. CO2 treatment could be an effective strategy for delayed fracture repair due to DM.Dec. 2020, BMJ open diabetes research & care, 8(2) (2), English, International magazine[Refereed]Scientific journal
- Clear cell sarcoma of tendons and aponeuroses (CCS) is a rare, malignant tumor arising in lower extremities with no effective treatment other than wide surgical resection. Here described is a case of primary CCS in the peroneal tendon of the right foot of a 54-year-old woman enrolled to undergo BNCT. The tumor mass post-BNCT disappeared totally without damage to other normal tissue, demonstrating, for the first time, the potential efficacy of BNCT in complete local control of CCS.Dec. 2020, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 166, 109324 - 109324, English, International magazine[Refereed]Scientific journal
- We herein describe soft tissue tumor arising in the lower extremity of a pediatric patient. The tumor displayed a unique and wide range of histological features, sheet-like and cohesive growth pattern consisting of enlarged round to epithelioid atypical cells with a large alveolar and pseudopapillary histological architecture, focally mimicking alveolar soft part sarcoma and MiT family translocation renal cell carcinoma. Tumor cells were focally immunoreactive for cytokeratin, S-100, and EMA. RNA sequencing identified a novel in-frame NR1D1 (exon 5)-MAML1 (exon 2) gene rearrangement resulting in the formation of a putative chimeric protein containing the N-terminal C4-type zing finger domains of NR1D1 and the C-terminal MAML1 protein, which was confirmed by subsequent RT-PCR, Sanger sequencing, and FISH assay. To the best of our knowledge, NR1D1-MAML1 fusion has not yet been described in any neoplasms, suggesting the emergence of a novel tumor entity.Dec. 2020, Virchows Archiv : an international journal of pathology, 477(6) (6), 891 - 895, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Cancer stem cells (CSCs) are considered to be responsible for tumor initiation, formation, and poor prognosis of cancer patients. However, the rarity of CSCs in clinical samples makes it difficult to elucidate characteristics of CSCs, especially in osteosarcoma (OS). The aim of this study is to verify whether it is possible to generate CSC-like cells by transducing defined factors into an OS cell line. METHODS: We retrovirally transduced the Octamer-binding transcription factor 3/4 (OCT3/4), Kruppel-like factor 4 (KLF4), and SRY-box transcription factor 2 (SOX2) genes into the MG-63 human OS cell line (MG-OKS). Parental and GFP-transduced MG-63 cells were used as negative control. We assessed the properties of the generated cells in vitro and in vivo. Multiple comparisons among groups were made using a one-way analysis of variance (ANOVA) followed by post hoc testing with Tukey's procedure. RESULTS: MG-OKS cells in vitro exhibited the significantly increased mRNA expression levels of CSC markers (CD24, CD26, and CD133), decreased cell growth, increased chemoresistance and cell migration, and enhanced sphere formation. Notably, MG-OKS cells cultured under osteogenic differentiation conditions showed strongly positive staining for both Alizarin Red S and alkaline phosphatase, indicating osteogenesis of the cells. Gene ontology analysis of microarray data revealed significant upregulation of epidermal-related genes. Tumors derived from MG-OKS cells in vivo were significantly larger than those from other cells in μCT analysis, and immunohistochemical staining showed that Ki-67, osteocalcin, and HIF-1α-positive cells were more frequently detected in the MG-OKS-derived tumors. CONCLUSIONS: In this study, we successfully generated OS CSC-like cells with significantly enhanced CSC properties following transduction of defined factors.Oct. 2020, Stem cell research & therapy, 11(1) (1), 429 - 429, English, International magazine[Refereed]Scientific journal
- (株)日本臨床社, Oct. 2020, 日本臨床, 78(増刊5 肉腫) (増刊5 肉腫), 310 - 314, Japanese【肉腫-基礎・臨床の最新知見-】肉腫の外科的治療 切除 In situ preparation
- Soft tissue sarcomas (STSs) are rare heterogeneous malignancies of mesenchymal origin. Pulmonary metastases develop in approximately 50% of the patients with high-grade STS, being the major cause of mortality in patients with metastatic STS. Pulmonary metastasectomy has been reported to contribute to long-term survival; however, an appropriate treatment has not been established. We aimed to identify factors associated with post-metastasis survival in STS patients with pulmonary metastasis and determine the appropriate treatment for each patient. We retrospectively reviewed the records of metastatic STS patients treated between 2000 and 2017 and analyzed the clinico-pathologic variables to identify factors associated with the survival. The median survival after pulmonary metastasis was 20.6 months, and the 1-, 3-, and 5-year survival rates were 68.6%, 36.0%, and 25.1%, respectively. The survival was significantly greater in patients who underwent pulmonary metastasectomy than in those without surgery (38.9 months vs. 10.5 months; p < 0.0001). Among those who did not undergo surgery, the survival was significantly greater in patients who received chemotherapy than in those without chemotherapy (19.1 months vs. 6.3 months, p = 0.037). Multivariate analysis identified pulmonary metastasectomy as the most important prognostic factor for post-metastasis survival (Hazard ratio 5.623; 95% Confidence Interval 2.733-11.572; p < 0.0001). In conclusion, pulmonary metastasectomy was the most important prognostic factor for post-metastasis survival in patients with metastatic STS. In addition, chemotherapy could prolong survival in patients who were not eligible for pulmonary resection. Although we should carefully weigh the risks and benefits, appropriate treatment for pulmonary metastases could contribute to long-time survival.Aug. 2020, Clinical & experimental metastasis, 37(4) (4), 509 - 517, English, International magazine[Refereed]Scientific journal
- 専門リハビリテーション研究会, Jun. 2020, 専門リハビリテーション, 19, 21 - 28, Japanese[Refereed]Scientific journal
- May 2020, PEDIATRIC HEMATOLOGY AND ONCOLOGY, 37(4) (4), 337 - 343, English, International magazine[Refereed]Scientific journal
- Apr. 2020, JBJS case connector, 10(2) (2), e0274[Refereed]Scientific journal
- OBJECTIVE: Joint contractures are a major complication following joint immobilization. However, no fully effective treatment has yet been found. Recently, carbon dioxide (CO2) therapy was developed and verified this therapeutic application in various disorders. We aimed to verify the efficacy of transcutaneous CO2 therapy for immobilization-induced joint contracture. METHOD: Twenty-two Wistar rats were randomly assigned to three groups: caged control, those untreated after joint immobilization, and those treated after joint immobilization. The rats were treated with CO2 for 20 min once a daily either during immobilization, (prevention) or during remobilization after immobilization (treatment). Knee extension motion was measured with a goniometer, and the muscular and articular factors responsible for contractures were calculated. We evaluated muscle fibrosis, fibrosis-related genes (collagen Type 1α1 and TGF-β1) in muscles, synovial intima's length, and fibrosis-related proteins (Type I collagen and TGF-β1) in the joint capsules. RESULTS: CO2 therapy for prevention and treatment improved the knee extension motion. Muscular and articular factors decreased in rats of the treatment group. The muscular fibrosis of treated rats decreased in the treatment group. Although CO2 therapy did not repress the increased expression of collagen Type 1α1, the therapy decreased the expression of TGF-β1 in the treatment group. CO2 therapy for treatment improved the shortening of the synovial membrane after immobilization and decreased the immunolabeling of TGF-β1 in the joint capsules. CONCLUSIONS: CO2 therapy may prevent and treat contractures after joint immobilization, and appears to be more effective as a treatment strategy for the deterioration of contractures during remobilization.2020, Physical therapy research, 23(2) (2), 113 - 122, English, Domestic magazine[Refereed]Scientific journal
- BACKGROUND: Clinicians have very limited options to improve fracture repair. Therefore, it is critical to develop a new clinically available therapeutic option to assist fracture repair biologically. We previously reported that the topical cutaneous application of carbon dioxide (CO2) via a CO2 absorption-enhancing hydrogel accelerates fracture repair in rats by increasing blood flow and angiogenesis and promoting endochondral ossification. The aim of this study was to assess the safety and efficacy of CO2 therapy in patients with fractures. METHODS: Patients with fractures of the femur and tibia were prospectively enrolled into this study with ethical approval and informed consent. The CO2 absorption-enhancing hydrogel was applied to the fractured lower limbs of patients, and then 100% CO2 was administered daily into a sealed space for 20 min over 4 weeks postoperatively. Safety was assessed based on vital signs, blood parameters, adverse events, and arterial and expired gas analyses. As the efficacy outcome, blood flow at the level of the fracture site and at a site 5 cm from the fracture in the affected limb was measured using a laser Doppler blood flow meter. RESULTS: Nineteen patients were subjected to complete analysis. No adverse events were observed. Arterial and expired gas analyses revealed no adverse systemic effects including hypercapnia. The mean ratio of blood flow 20 min after CO2 therapy compared with the pre-treatment level increased by approximately 2-fold in a time-dependent manner. CONCLUSIONS: The findings of the present study revealed that CO2 therapy is safe to apply to human patients and that it can enhance blood flow in the fractured limbs. TRIAL REGISTRATION: This study has been registered in the UMIN Clinical Trials Registry (Registration number: UMIN000013641, Date of registration: July 1, 2014).Nov. 2019, BMC Musculoskelet Disord, 20(1) (1), 563 - 563, English, International magazine[Refereed]Scientific journal
- Soft tissue myoepithelial tumors are very rare mesenchymal tumors that are currently categorized as miscellaneous neoplasms with uncertain differentiation. Although the molecular pathogenesis of soft tissue myoepithelial tumors remains unclear, EWSR1 gene fusions with a variety of partner genes are regarded as one of the major pathogenic driver events in these tumors. We herein present a case of a deep soft tissue malignant myoepithelial tumor arising in the thigh with multiple pulmonary metastases. This tumor displayed diverse and unique histological features, namely, an epithelioid glandular growth pattern, pseudorosette-like formation, and a diffuse nest and cord-like pattern within an abundant myxoid matrix. Next-generation RNA sequencing identified a novel fusion transcript, in which the in-frame junctional reads contained exon 9 of EWSR1 and exon 2 of VGLL1, resulting in the formation of a putative chimeric protein with the N-terminal transcriptional activation domain of EWSR1 and C-terminal full length of the VGLL1 protein. EWSR1-VGLL1 fusion has not been described in neoplasm before. Further molecular and functional experiments on the present EWSR1-VGLL1 fusion gene are required to elucidate its tumorigenic effect.Nov. 2019, Genes, chromosomes & cancer, 59(4) (4), 249 - 254, English, International magazine[Refereed]Scientific journal
- Oct. 2019, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(5) (5), 886 - 891, English[Refereed]Scientific journal
- BACKGROUND: Limitations of shoulder range of motion (ROM) have been reported to be at high risk for shoulder disorders in baseball players. In this study, we assessed posterior shoulder muscle stiffness using shear wave elastography in baseball players with and without posterior shoulder tightness. MATERIALS AND METHODS: In total, 21 college baseball players volunteered to participate in this study. Passive ROMs for shoulder abduction and horizontal adduction were measured using a goniometer. Subsequently, we divided all participants into 2 groups based on the differences between bilateral shoulder ROMs: STIFF+ and STIFF- groups. Thickness and elasticity of the posterior and inferior shoulder muscles were assessed using ultrasound. RESULTS: Shoulder abduction ROM on the throwing side was 114.5° ± 5.3° and 131.3° ± 5.7° in the STIFF+ and STIFF- groups, respectively, which was significantly different between the 2 groups (P = .023). Horizontal adduction ROM on the throwing side was 96.6° ± 4.9° and 110.9° ± 4.8° in the STIFF+ and STIFF- groups, respectively, which was also significantly different between the 2 groups (P = .014). The elasticity of infraspinatus and lower trapezius in the STIFF+ group was significantly greater than that in the STIFF- group (P = .018 and .033, respectively). DISCUSSION: In this study, we found that the elasticity of infraspinatus and lower trapezius in stiff shoulders was significantly greater than that in nonstiff shoulders, which indicated that the infraspinatus and lower trapezius could be the key muscles in posterior shoulder tightness.Sep. 2019, Journal of shoulder and elbow surgery, 29(3) (3), 571 - 577, English, International magazine[Refereed]Scientific journal
- OBJECTIVES: To investigate which clinical assessments are suitable for differentiating patients who fall from patients who do not fall in patients with idiopathic normal pressure hydrocephalus (iNPH). DESIGN: Prospective observational study. SETTING: Osaka Medical College Hospital. PARTICIPANTS: Patients with a cerebrospinal fluid tap test (TT) result meeting the diagnosis criteria for iNPH (N=68). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Participants were assessed before the TT based on the following: timed Up and Go (TUG), 10-meter walk test (10MWT), Functional Gait Assessment (FGA), Berg Balance Scale (BBS), isometric quadriceps strength (QS), and a history of falls within the past 6 months. RESULTS: The full area under the curve (AUC) of the receiver operating characteristic curves and 95% confidence interval were found to be 0.651 (95% confidence interval, 0.503-0.775) for the TUG, 0.692 (95% confidence interval, 0.540-0.812) for the 10MWT, 0.869 (95% confidence interval, 0.761-0.933) for the FGA, and 0.796 (95% confidence interval, 0.663-0.886) for the BBS; except for QS, they all were identified as statistically significant predictive variables. In the TUG<20 seconds group (n=47), the FGA (AUC 0.849 [95% confidence interval, 0.698-0.932]) and BBS (AUC 0.734 [95% confidence interval, 0.550-0.862]) were found to be statistically significant predictive variables; however, the other assessments were not. In the TUG<15 seconds group (n=34), the FGA was found to be the only statistically significant predictive variable (AUC 0.842 [95% confidence interval, 0.640-0.942]), whereas the other assessments were not. The AUC of the FGA was statistically significantly greater than those of the other assessments. CONCLUSIONS: Our findings indicate that patients with iNPH who fall experience falls due to dynamic balance dysfunction during gait rather than lower limb muscle strength. The FGA may be more suitable than other assessments for differentiating patients who fall from patients who do not fall in patients with mild iNPH.Aug. 2019, Archives of physical medicine and rehabilitation, 100(8) (8), 1458 - 1466, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Joint contractures are a major complication in patients with spinal cord injuries. Positioning, stretching, and physical therapy are advocated to prevent and treat contractures; however, many patients still develop them. Joint motion (exercise) is crucial to correct contractures. Transcutaneous carbon dioxide (CO2) therapy was developed recently, and its effect is similar to that of exercise. This therapy may be an alternative or complementary approach to exercise. QUESTION/PURPOSES: Using an established model of spinal cord injury in rats with knee flexion contractures, we sought to clarify whether transcutaneous CO2 altered (1) contracture, as measured by ROM; (2) muscular and articular factors contributing to the loss of ROM; (3) fibrosis and fibrosis-related gene expression in muscle; and (4) the morphology of and fibrosis-related protein expression in the joint capsule. METHODS: Thirty-six Wistar rats were divided into three equal groups: caged control, those untreated after spinal cord injury, and those treated with CO2 after spinal cord injury. The rats were treated with CO2 from either the first day (prevention) or 15th day (treatment) after spinal cord injury for 2 or 4 weeks. The hindlimbs of rats in the treated group were exposed to CO2 gas for 20 minutes once daily. Knee extension ROM was measured with a goniometer and was measured again after myotomy. We calculated the muscular and articular factors responsible for contractures by subtracting the post-myotomy ROM from that before myotomy. We also quantified histologic muscle fibrosis and evaluated fibrosis-related genes (collagen Type 1, α1 and transforming growth factor beta) in the biceps femoris muscle with real-time polymerase chain reaction. The synovial intima's length was measured, and the distribution of fibrosis-related proteins (Type I collagen and transforming growth factor beta) in the joint capsule was observed with immunohistochemistry. Knee flexion contractures developed in rats after spinal cord injuries at all timepoints. RESULTS: CO2 therapy improved limited-extension ROM in the prevention group at 2 weeks (22° ± 2°) and 4 weeks (29° ± 1°) and in the treatment group at 2 weeks (31° ± 1°) compared with untreated rats after spinal cord injuries (35° ± 2°, mean difference, 13°; 39° ± 1°, mean difference, 9°; and 38° ± 1°, mean difference, 7°, respectively) (95% CI, 10.50-14.86, 8.10-10.19, and 4.73-9.01, respectively; all p < 0.001). Muscular factors decreased in treated rats in the prevention group at 2 weeks (8° ± 2°) and 4 weeks (14°± 1°) and in the treatment group at 2 weeks (14 ± 1°) compared with untreated rats (15° ± 1°, 4.85-9.42; 16° ± 1°, 1.24-3.86; and 17° ± 2°, 1.16-5.34, respectively; all p < 0.05). The therapy improved articular factors in the prevention group at 2 weeks (4° ± 1°) and 4 weeks (6° ± 1°) and in the treatment group at 2 weeks (8° ± 1°) compared with untreated rats (10° ± 1°, 4.05-7.05; 12° ± 1°, 5.18-8.02; and 11° ± 2°, 1.73-5.50, respectively; all p < 0.05). CO2 therapy decreased muscle fibrosis in the prevention group at 2 weeks (p < 0.001). The expression of collagen Type 1, α1 mRNA in the biceps femoris decreased in treated rats in the prevention group at 2 and 4 weeks compared with untreated rat (p = 0.002 and p = 0.008, respectively), although there was little difference in the expression of transforming growth factor beta (p > 0.05). CO2 therapy did not improve shortening of the synovial intima at all timepoints (all p > 0.05). CO2 therapy decreased transforming growth factor beta immunolabeling in joint capsules in the rats in the prevention group at 2 weeks. The staining intensity and Type I collagen pattern showed no differences among all groups at all timepoints. CONCLUSION: CO2 therapy may be useful for preventing and treating contractures after spinal cord injuries. CO2 therapy particularly appears to be more effective as a prevention and treatment strategy in early-stage contractures before irreversible degeneration occurs, as shown in a rat model. CLINICAL RELEVANCE: Our findings support the idea that CO2 therapy may be able to improve the loss of ROM after spinal cord injury.Aug. 2019, Clinical orthopaedics and related research, 477(8) (8), 1934 - 1946, English, International magazine[Refereed]Scientific journal
- OBJECTIVES: The factors influencing falls in idiopathic normal pressure hydrocephalus (iNPH) remain unclear, although iNPH-associated gait and balance disturbances can lead to an increased risk of falls. This study aimed to investigate the associations among fall status, gait variability, balance function in iNPH, and to identify fall-related factors in iNPH. PATIENTS AND METHODS: Sixty-three patients with iNPH with a positive cerebrospinal fluid tap test result according to the iNPH diagnosis criteria participated in this prospective cross-sectional study. Patients were assessed using the 10-meter walk test (10MWT), the Functional Gait Assessment (FGA), the Berg Balance Scale (BBS), and the isometric quadriceps strength (QS). We also investigated each patient's history of falls in the past 6 months. Gait variability was measured using a triaxial accelerometer attached to the patient's torso at the L3 vertebra level during the 10MWT. RESULTS: Fall status correlated significantly with gait variability (measured as the coefficient of variation; CV) in step time and movement trajectory amplitude (i.e., center of mass movement) in the medial/lateral (ML) and vertical (VT) directions, with balance function as assessed by FGA and BBS scores. In contrast, QS was not correlated with fall status. The independent variables associated with the risk of falling were step time CV, FGA score, and age. CONCLUSION: The factors associated with the risk of falling in iNPH were aging and gait-balance instability, particularly temporal gait variability and dynamic balance dysfunction. Our results may enable physicians to identify the patients with iNPH who are at risk of falling and implement suitable prevention strategies.Aug. 2019, Clinical neurology and neurosurgery, 183, 105385 - 105385, English, International magazine[Refereed]Scientific journal
- Jul. 2019, BMC Cancer, 19(1) (1), 725[Refereed]Scientific journal
- STUDY DESIGN: Experimental animal study. OBJECTIVES: Spastic hypertonia is originally believed to cause contractures from clinical observations. Botulinum toxin is effective for the treatment of spasticity and is widely used in patients who have joints with contractures. Using an established rat model with knee contractures after spinal cord injuries, we aimed to verify whether hypertonia contributes to contracture development, and the botulinum toxin improves structural changes in muscles and joint components responsible for contractures. SETTING: University laboratory in Japan. METHODS: To evaluate the effect of hypertonia on contracture development, the rats received botulinum toxin injections after spinal cord injuries. Knee extension motion was measured with a goniometer applying a standardized torque under anesthesia, and the contribution by muscle or non-muscle structures to contractures were calculated by measuring joint motion before and after the myotomies. We quantitatively measured the muscle atrophy, muscle fibrosis, and synovial intima length. RESULTS: Botulinum toxin injections significantly improved contractures, whereas did not completely prevent contracture development. Botulinum toxin was effective in improving the muscular factor, but little difference in the articular factor. Spinal cord injuries induced muscle atrophy, and botulinum toxin significantly accelerated muscle atrophy and fibrosis. The synovial intima length decreased significantly after spinal cord injuries, and botulinum toxin did not improve this shortening. CONCLUSIONS: This animal study provides new evidence that hypertonia is not the sole cause rather is the partial contributor of contractures after spinal cord injuries. Furthermore, botulinum toxin has adverse effects in the muscle.Jun. 2019, Spinal cord, 57(10) (10), 850 - 857, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Bone defects may occur because of severe trauma, nonunion, infection, or tumor resection. However, treatments for bone defects are often difficult and have not been fully established yet. We previously designed an efficient system of topical cutaneous application of carbon dioxide (CO2) using a novel hydrogel, which facilitates CO2 absorption through the skin into the deep area within a limb. In this study, the effect of topical cutaneous application of CO2 on bone healing was investigated using a rat femoral defect model. METHODS: In this basic research study, an in vivo bone defect model, fixed with an external fixator, was created using a rat femur. The affected limb was shaved, and CO2 was applied for 20 min/day, 5 days/week. In the control animals, CO2 gas was replaced with air. Radiographic, histological, biomechanical, and genetic assessments were performed to evaluate bone healing. RESULTS: Radiographically, bone healing rate was significantly higher in the CO2 group than in the control group at 4 weeks (18.2% vs. 72.7%). The degree of bone healing scored using the histopathological Allen grading system was significantly higher in the CO2 group than in the control group at 2 weeks (1.389 ± 0.334 vs. 1.944 ± 0.375). The ultimate stress, extrinsic stiffness, and failure energy were significantly greater in the CO2 group than in the control group at 4 weeks (3.2 ± 0.8% vs. 38.1 ± 4.8%, 0.6 ± 0.3% vs. 41.5 ± 12.2%, 2.6 ± 0.8% vs. 24.7 ± 5.9%, respectively.). The volumetric bone mineral density of the callus in micro-computed tomography analysis was significantly higher in the CO2 group than in the control group at 4 weeks (180.9 ± 43.0 mg/cm3 vs. 247.9 ± 49.9 mg/cm3). Gene expression of vascular endothelial growth factor in the CO2 group was significantly greater than that in the control group at 3 weeks (0.617 ± 0.240 vs. 2.213 ± 0.387). CONCLUSIONS: Topical cutaneous application of CO2 accelerated bone healing in a rat femoral defect model. CO2 application can be a novel and useful therapy for accelerating bone healing in bone defects; further research on its efficacy in humans is warranted.May 2019, BMC musculoskeletal disorders, 20(1) (1), 237 - 237, English, International magazine[Refereed]Scientific journal
- Hyperglycemia impairs oxidative capacity in skeletal muscle. Muscle oxidative capacity is regulated by peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α). Transcutaneous carbon dioxide (CO2) enhances PGC-1α expression in skeletal muscle. Therefore, the aim of this study was to clarify the effects of CO2 therapy on muscle oxidative capacity impaired by streptozotocin (STZ)-induced hyperglycemia. Eight-week-old male Wistar rats were randomly divided into 4 groups: control, CO2 treatment, STZ-induced hyperglycemia, and STZ-induced hyperglycemia treated with CO2. STZ-induced hyperglycemia resulted in a decrease of muscle oxidative capacity and decreased PGC-1α and cytochrome c oxidase subunit 4 (COX-4) expression levels; while, application of transcutaneous CO2 attenuated this effect, and enhanced the expression levels of endothelial nitric oxide synthesis (eNOS). These results indicate that transcutaneous CO2 improves impaired muscle oxidative capacity via enhancement of eNOS and PGC-1α-related signaling in the skeletal muscle of rats with hyperglycemia.May 2019, General physiology and biophysics, 38(3) (3), 237 - 244, English, International magazine[Refereed]Scientific journal
- 日本脊椎脊髄病学会, May 2019, Journal of spine research : official journal of the Japanese Society for Spine Surgery and Related Research, 10(5) (5), 898 - 904, JapaneseThe Effectiveness and Limitation of Spine Surgery for Spinal Metastasis
- The purpose of the present study was to determine the effects of transcutaneous CO2 application on the blood flow and capillary architecture of the soleus muscle in rats with streptozotocin (STZ)-induced hyperglycemia. Wistar rats were randomly divided into four groups: control, control + CO2-treated, STZ-induced hyperglycemia, and STZ-induced hyperglycemia + CO2-treated groups. Blood flow in soleus muscle increased during the transcutaneous CO2 exposure, and continued to increase for 30 min after the treatment. In addition, the transcutaneous CO2 attenuated a decrease in capillary and the expression level of eNOS and VEGF protein, and an increase in the expression level of MDM-2 and TSP-1 protein of soleus muscle due to STZ-induced hyperglycemia. These results indicate that the application of transcutaneous CO2 could improve capillary regression via the change of pro- and anti-angiogenesis factors, which might be induced by an increase in blood flow.Mar. 2019, J Physiol Sci, 69(2) (2), 317 - 326, English, Domestic magazine[Refereed]Scientific journal
- <p> [Purpose] The effect of physiotherapy on stooped posture in Parkinson's disease patients remains to be clarified. Therefore, the purpose of this study was to investigate whether comprehensive physiotherapy-based rehabilitation can improve stooped posture in Parkinson's disease patients. [Participants and Methods] The participants were Parkinson's disease patients with stoopThe Society of Physical Therapy Science, Dec. 2018, Journal of Physical Therapy Science, 30(12) (12), 1440 - 1445, English, Domestic magazine[Refereed]Scientific journal
- Hypoxia plays a significant role in cancer progression, including metastatic bone tumors. We previously reported that transcutaneous carbon dioxide (CO2) application could decrease tumor progression through the improvement of intratumor hypoxia. Therefore, we hypothesized that decreased hypoxia using transcutaneous CO2 could suppress progressive bone destruction in cancer metastasis. In the present study, we examined the effects of transcutaneous CO2 application on metastatic bone destruction using an animal model. The human breast cancer cell line MDA-MB-231 was cultured in vitro under three different oxygen conditions, and the effect of altered oxygen conditions on the expression of osteoclast-differentiation and osteolytic factors was assessed. An in vivo bone metastatic model of human breast cancer was created by intramedullary implantation of MDA-MB-231 cells into the tibia of nude mice, and treatment with 100% CO2 or a control was performed twice weekly for two weeks. Bone volume of the treated tibia was evaluated by micro-computed tomography (µCT), and following treatment, histological evaluation was performed by hematoxylin and eosin staining and immunohistochemical staining for hypoxia-inducible factor (HIF)-1α, osteoclast-differentiation and osteolytic factors, and tartrate-resistant acid phosphatase (TRAP) staining for osteoclast activity. In vitro experiments revealed that the mRNA expression of RANKL, PTHrP and IL-8 was significantly increased under hypoxic conditions and was subsequently reduced by reoxygenation. In vivo results by µCT revealed that bone destruction was suppressed by transcutaneous CO2, and that the expression of osteoclast-differentiation and osteolytic factors, as well as HIF-1α, was decreased in CO2-treated tumor tissues. In addition, multinucleated TRAP-positive osteoclasts were significantly decreased in CO2-treated tumor tissues. Hypoxic conditions promoted bone destruction in breast cancer metastasis, and reversal of hypoxia by transcutaneous CO2 application significantly inhibited metastatic bone destruction along with decreased osteoclast activity. The findings in this study strongly indicated that transcutaneous CO2 application could be a novel therapeutic strategy for treating metastatic bone destruction.Oct. 2018, Oncology reports, 40(4) (4), 2079 - 2087, English, International magazine[Refereed]Scientific journal
- An infant boy underwent hip disarticulation for infantile fibrosarcoma immediately after birth. His rehabilitation began when he was 4 mos old and involved training with his left (residual) leg. He could stand with support at 12 mos. His initial prosthesis fitting was performed at the age of 13 mos. He could stand and walk with support at 15 mos of age and could walk with no additional support and go up and down stairs at 2 yrs. A single-axis prosthetic knee joint was introduced at the age of 2 yrs 3 mos. His first gait using a hip prosthesis was successful, and his prosthesis was replaced at appropriate intervals with no major problems. The authors believe that the key to achieving a successful prosthetic gait in children is good communication among the medical team, which should comprise an orthopedic doctor, rehabilitation doctor, nurse, physical therapist, prosthetist/orthotist, and the patient's parents.Oct. 2018, American journal of physical medicine & rehabilitation, 97(10) (10), e90-e92 - e92, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Chronic expanding hematoma is a rare entity resulting from trauma or surgery. This condition usually occurs in soft tissue, such as the trunk or extremities, while chronic expanding hematoma arising from bone has not been reported previously. We describe an unusual case of a huge intraosseous chronic expanding hematoma arising from the ilium, which had grown over a 40-year period following hip surgeries. CASE PRESENTATION: A 57-year-old Japanese woman presented with a 1.5-year history of right hip pain. She had a history of bilateral developmental dysplasia of the hip and had undergone bilateral arthroplasties in childhood. A physical examination revealed a large, firm, immobile mass at her right ilium. Based on radiographic findings, a type of slow-growing bone tumor was suspected, and an incisional biopsy was performed. A histopathologic examination revealed large amounts of old clotted blood within the lesion, and the capsule of the lesion was composed of dense, fibrous, connective tissue. There was no evidence of neoplasia, and chronic expanding hematoma was suspected. The lesion was resistant to conservative treatment, and so we performed an internal hemipelvectomy (including the capsule of the mass) and a reconstruction by hip transposition 2.5 years after the incisional biopsy. There was no recurrence of chronic expanding hematoma at the most recent follow-up of 1 year and 8 months postoperatively. CONCLUSIONS: A chronic expanding hematoma is characterized by its persistence and increasing size more than 1 month after the trauma or surgical event suspected of causing hemorrhage. To the best of our knowledge, this is the first report of chronic expanding hematoma arising from bone. We performed internal hemipelvectomy and hip transposition, and there has so far been no recurrence. This disease may be considered a differential diagnosis for bone tumor when the patient has a history of surgery or trauma, regardless of how many years have passed since the index event.Sep. 2018, Journal of medical case reports, 12(1) (1), 265 - 265, English, International magazine[Refereed]Scientific journal
- OBJECTIVES: This study aimed to confirm whether cerebrospinal fluid (CSF) shunting for idiopathic normal-pressure hydrocephalus (iNPH) improves postural instability, and to investigate the relationship between postural control and gait ability. PATIENTS AND METHODS: Twenty-three iNPH patients and 18 age-matched healthy controls (HC) were examined using the timed up and go (TUG) test and a force platform for calculating the center of pressure (COP) trajectory during voluntary multidirectional leaning and quiescent standing. We determined the patients' TUG values and COP trajectories before and after shunt surgery. RESULTS: Postural sway was greater in iNPH patients before shunt surgery and the TUG value was lower in iNPH patients before shunt surgery than in HC. Voluntary COP movements were significantly improved in iNPH patients at 1 week post-surgery, but no significant changes in quiescent standing were found between pre- and post-surgery. Significant correlations were found between the TUG value and voluntary COP movements in iNPH patients before and after surgery, but no significant correlations were observed between the TUG value and quiescent standing. CONCLUSION: Our results indicate that CSF shunting in iNPH patients may improve voluntary postural control and reduce the risk of falling. Impaired voluntary COP control in iNPH patients may reflect the underlying pathophysiological mechanisms of balance disturbance in iNPH.Sep. 2018, Clinical neurology and neurosurgery, 172, 46 - 50, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Giant cell tumor of bone (GCTB) is an intermediate tumor known to be locally aggressive, but rarely metastasizing. To plan a prospective study of GCTB, we performed a questionnaire survey for institutions participating in the Bone and Soft Tissue Tumor Study Group (BSTTSG) in the Japan Clinical Oncology Group (JCOG) in 2015. METHODS: We reviewed 158 consecutive patients with primary GCTB treated with curettage without perioperative denosumab from 2008 to 2010 in Japan. We investigated local and distant recurrence rates after definitive curettage. We also investigated the recurrence rate after treatment with preoperative and/or postoperative denosumab with curettage in recent years. There were 40 patients treated with perioperative denosumab, and the factors affecting recurrence in them were investigated. RESULTS: Answers were available from 24 of 30 institutions (80.0%) participating in JCOG BSTTSG. Thirty (19.0%) and 4 (2.5%) of 158 patients developed local and distant recurrence after curettage without perioperative denosumab from 2008 to 2010, respectively. Campanacci grade and embolization before surgery were significantly associated with increasing incidence of local recurrence after curettage (p = 0.034 and p = 0.022, respectively). In patients treated with perioperative desnosumab, 120 mg denosumab was administered subcutaneously for a median 6 (2-41) and 6 (1-14) times in preoperative and postoperative settings, respectively. The recurrence rates were 6 of 21 (28.6%), 2 of 9 (22.2%), and 0 of 10 (0.0%) in the preoperative, postoperative, and both pre- and postoperative denosumab treatment groups, respectively. With all of the preoperative treatments, administration exceeding five times was significantly associated with a decreased incidence of local recurrence after curettage (p < 0.001). CONCLUSION: The recurrence rate of GCTB was still high after curettage, especially in Campanacci grade III, and improvements in the therapeutic strategy are needed in this cohort. There is a possibility that a sufficient dose of preoperative denosumab can reduce recurrence after curettage. Recently, we have started a clinical trial, JCOG1610, to investigate the efficacy of preoperative denosumab in patients who can be treated with curettage in GCTB.Aug. 2018, World J Surg Oncol, 16(1) (1), 160 - 160, English, International magazine[Refereed]Scientific journal
- (株)医学書院, Jul. 2018, 臨床整形外科, 53(7) (7), 643 - 648, Japanese全身画像検索が診断に有用であった慢性再発性多発性骨髄炎の2例[Refereed]Scientific journal
- Radiotherapy (RT) is one of the main treatment modalities for oral squamous cell carcinoma (OSCC), however, radioresistance is a major impediment to its clinical success and poses as a concern that needs to be addressed. Tumor hypoxia is known to be significantly associated with radioresistance in various malignancies, hence, resolving the hypoxic state of a tumor may improve the antitumor effect of RT on OSCC. We have previously revealed that transcutaneous CO2 induced mitochondrial apoptosis and suppressed tumor growth in OSCC by resolving hypoxia. Considering the previous study, we hypothesized that transcutaneous CO2 may enhance the antitumor effect of RT on OSCC by improving intratumoral hypoxia, thereby overcoming radioresistance. In the present study, the combination of transcutaneous CO2 and RT significantly inhibited tumor growth compared with other treatments. This combination therapy also led to decreased expression of HIF-1α in parallel with increased expression of the cleaved forms of caspase-3-8-9 and PARP, which play essential roles in mitochondrial apoptosis. Additionally, the combination therapy increased the expression of ROS modulator 1 and subsequent mitochondrial ROS production, compared to RT alone. These results indicated that transcutaneous CO2 could potentially improve the antitumor effect of RT by decreasing the intratumoral hypoxia and increasing the mitochondrial apoptosis. Our findings indicated that CO2 therapy may be a novel adjuvant therapy in combination with RT for OSCC.Jul. 2018, Oncology reports, 40(1) (1), 434 - 442, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Although gait and balance disturbances are core symptoms of idiopathic normal pressure hydrocephalus (iNPH), the ambulatory center of mass (COM) movements in patients with iNPH remain unclear. We aimed to clarify the ambulatory COM movements using an accelerometer on the patients' lower torsos and to investigate the changes in COM movement after cerebrospinal fluid tap tests (TT) and shunt surgeries (SS). METHODS: Twenty-three patients with iNPH and 18 age-matched healthy controls (HCs) were recruited. A triaxial accelerometer was fixed with a belt onto each participant's torso at the L3 vertebra level. We assessed each patient's 10-m gait before TT, 3 days after TT, and 1 week after SS. RESULTS: Compared to the HCs, the patients exhibited decreased gait velocities, increased step numbers, and increased step times. Their movement trajectory amplitudes (i.e., the COM movements) were increased in the medial/lateral direction and decreased in the vertical direction. They also exhibited greater variability (measured as coefficients of variation) in step time and movement trajectory amplitude in both the medial/lateral and vertical directions. The patients' gait parameters were significantly improved after TT and SS. SIGNIFICANCE: Our results suggest that iNPH-associated gait disturbances could cause abnormal ambulatory COM movements and that these disturbances are mitigated by TT and SS.Jun. 2018, Gait & posture, 63, 5 - 9, English, International magazine[Refereed]Scientific journal
- OBJECTIVES: We investigated the differences in postural control disability between idiopathic normal pressure hydrocephalus (iNPH) and Parkinson's disease (PD). PATIENTS AND METHODS: Twenty-seven iNPH patients, 20 PD patients, and 20 healthy controls (HCs) were examined using the Timed Up and Go test (TUG) and a force platform for recording the center of pressure (COP) trajectory during quiescent standing and voluntary multidirectional leaning (forward, backward, right, and left for 10 s each). RESULTS: In the leaning task, postural control in PD patients was impaired during forward and backward leaning, whereas postural control in iNPH patients was impaired in all directions. In particular, postural control during right and left leaning was significantly worse in iNPH patients than in PD patients. No significant difference was observed between iNPH and PD patients in TUG and postural sway during quiescent standing. CONCLUSION: Our results showed that the characteristics of impaired voluntary COP control in iNPH and PD patients might reflect pathophysiological differences in postural instability for each disease. In particular, postural instability during right and left leaning in iNPH patients may be responsible for wider steps and a higher risk of falling.Feb. 2018, Clinical neurology and neurosurgery, 165, 103 - 107, English, International magazine[Refereed]Scientific journal
- Blackwell Publishing Ltd, Feb. 2018, Acta Neurologica Scandinavica, 137(2) (2), 238 - 244, English[Refereed]Scientific journal
- Nov. 2017, ANTICANCER RESEARCH, 37(11) (11), 6097 - 6106, English[Refereed]Scientific journal
- Oct. 2017, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(4) (4), 724 - 728, English, Domestic magazine[Refereed]Scientific journal
- Oct. 2017, CLINICAL SPINE SURGERY, 30(8) (8), E1026 - E1032, EnglishProspective Cohort Study of Performance Status and Activities of Daily Living After Surgery for Spinal Metastasis[Refereed]Scientific journal
- (一社)日本脊椎脊髄病学会, Feb. 2017, J Spine Res., 8(2) (2), 139 - 146, Japanese脊椎転移に対する集学的治療の予後改善効果Author：角谷 賢一朗(神戸大学 大学院整形外[Refereed]Scientific journal
- Jan. 2017, INTERNATIONAL JOURNAL OF ONCOLOGY, 50(1) (1), 23 - 30, English[Refereed]Scientific journal
- INTRODUCTION: Most community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections affect skin or soft tissues, while invasive and life-threatening illnesses including osteomyelitis are less common. CA-MRSA infections occur especially in the pediatric age group, while the occurrence of CA-MRSA osteomyelitis in adults is uncommonly reported. PRESENTATION OF CASES: A rare case of acute osteomyelitis of the femur caused by Panton-Valentine leukocidin (PVL)-positive CA-MRSA in a 37-year-old man in good health is presented. A pure bone biopsy revealed extensive inflammation, suggestive of acute osteomyelitis, with no evidence of neoplasm, and PVL-positive MRSA was isolated from the culture. Antibiotic treatment, with 6 weeks of intravenous vancomycin and 4 weeks of clindamycin, followed by 2 weeks of oral linezolid, was given, and 2 years after treatment completion, there has been no relapse of infection. CONCLUSION: This case strongly suggests that we need to be aware of CA-MRSA osteomyelitis, which requires a high level of suspicion, prompt diagnosis, and appropriate antibiotic treatment.2017, International journal of surgery case reports, 33, 4 - 7, English, International magazine[Refereed]Scientific journal
- Jan. 2017, Int Orthop., 41(6) (6), 1265 - 1271, EnglishQuality of life and cost-utility of surgical treatment for patients with spinal metastases: prospective cohort study.[Refereed]Scientific journal
- Jan. 2017, Oncol Rep., 37(6) (6), 3688 - 3694, EnglishOptimization of antitumor treatment conditions for transcutaneous CO2 application: An in vivo study.[Refereed]Scientific journal
- Jul. 2016, JOURNAL OF FOOT & ANKLE SURGERY, 55(4) (4), 838 - 841, English[Refereed]Scientific journal
- Apr. 2016, INTERNATIONAL JOURNAL OF ONCOLOGY, 48(4) (4), 1493 - 1498, English[Refereed]Scientific journal
- (一社)日本脊椎脊髄病学会, Jan. 2016, Journal of Spine Research, 7(1) (1), 25 - 30, Japanese70歳以上脊椎転移に対する手術成績[Refereed]Scientific journal
- Dec. 2015, APPLIED RADIATION AND ISOTOPES, 106, 195 - 201, English[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Sep. 2015, 中部日本整形外科災害外科学会雑誌, 58(5) (5), 1076 - 1077, Japanese初発転移が膵であった腓骨原発骨肉腫の1例Scientific journal
- Sep. 2015, INTERNATIONAL JOURNAL OF ONCOLOGY, 47(3) (3), 891 - 899, English[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Jul. 2015, 中部日本整形外科災害外科学会雑誌, 58(4) (4), 717 - 718, Japanese小児の足関節内に生じた骨軟骨形成性腫瘍の1例Scientific journal
- (一社)中部日本整形外科災害外科学会, Mar. 2015, 中部日本整形外科災害外科学会雑誌, 58(2) (2), 275 - 276, Japanese緊急的に股関節離断術を施行した急速に増大する乳児型線維肉腫の1例Scientific journal
- Sep. 2014, 日本足の外科学会雑誌, 35(1号) (1号), 334 - 336, Japanese距骨に生じた骨軟骨腫の一例[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Sep. 2014, 中部日本整形外科災害外科学会雑誌, 57(5号) (5号), 1061 - 1062, Japanese[Refereed]Scientific journal
- Aug. 2014, INTERNATIONAL JOURNAL OF ONCOLOGY, 45(2) (2), 732 - 738, English[Refereed]Scientific journal
- Jul. 2014, PLOS ONE, 9(7) (7), e100530, English[Refereed]Scientific journal
- Mar. 2014, KNEE, 21(2) (2), 387 - 390, English[Refereed]Scientific journal
- Mar. 2014, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 22(3) (3), 576 - 580, English[Refereed]Scientific journal
- PURPOSE: To evaluate the efficacy of intraarterial infusion of CO2-saturated solution in rabbit VX2 thigh tumors. MATERIALS AND METHODS: Fourteen Japanese white rabbits had VX2 tumors implanted in the right femoral muscle 3 weeks before intraarterial infusion. Rabbits were divided into control and CO2 groups (n = 7 each). Fifty milliliters of solution (saline solution and CO2-saturated solution for the control and CO2 groups, respectively) was administered via a 24-gauge catheter in the ipsilateral iliac artery close to the feeding artery of the VX2 tumor. All rabbits were killed for tumor harvest on day 3 after the procedure. Tumor volume was evaluated with in vivo direct caliper measurement and contrast-enhanced computed tomography (CT). Tumor apoptotic changes were examined by DNA fragmentation assay and immunoblot analysis. The tumor growth ratio and apoptotic cell rate were analyzed. RESULTS: Body weight was equally increased in both groups, but the mean tumor growth ratio was significantly decreased in the CO2 group compared with the control group (-9.5% ± 7.9 vs 27.2% ± 6.6 and 4.1% ± 4.4 vs 35.7% ± 4.5 measured by calipers and contrast-enhanced CT, respectively; P < .01). Apoptotic activity in the CO2 group was higher than in the control group (number of apoptotic cells per area, 215.0 ± 58.7 vs 21.8 ± 5.4; adjusted relative density of cleaved caspase-3, 0.23 ± 0.07 vs 0.04 ± 0.01; P < .01). CONCLUSIONS: Intraarterial infusion of CO2-saturated solution inhibits rabbit VX2 thigh tumor growth by activation of apoptotic cell death through cleaved caspase-3 upregulation.Mar. 2014, Journal of vascular and interventional radiology : JVIR, 25(3) (3), 469 - 76, English, International magazine[Refereed]Scientific journal
- Mar. 2014, JOURNAL OF ORTHOPAEDIC RESEARCH, 32(3) (3), 455 - 463, English[Refereed]Scientific journal
- Mar. 2014, INTERNATIONAL ORTHOPAEDICS, 38(3) (3), 531 - 537, English[Refereed]Scientific journal
- Mar. 2014, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 22(3) (3), 576 - 580, English[Refereed]Scientific journal
- Mar. 2014, INTERNATIONAL ORTHOPAEDICS, 38(3) (3), 509 - 515, English[Refereed]Scientific journal
- Mar. 2014, JOURNAL OF ORTHOPAEDIC RESEARCH, 32(3) (3), 455 - 463, English[Refereed]Scientific journal
- 2014, Book of Abstracts for 16th International Congress on Neutron Capture Therapy, Cancer Society of Finland, 79 - 80, EnglishBoron neutron capture therapy as new treatment for clear cell sarcoma: trial on a lung metastasis model of clear cell sarcomaInternational conference proceedings
- Elsevier, 2014, Knee, 21(2) (2), 387 - 390, English[Refereed]Scientific journal
- Jan. 2014, SCIENTIFIC REPORTS, 4, 3916, English[Refereed]Scientific journal
- Oct. 2013, JBJS case connector, 3(4) (4), e120[Refereed]Scientific journal
- Oct. 2013, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 21(10) (10), 2338 - 2345, English[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Sep. 2013, 中部日本整形外科災害外科学会雑誌, 56(秋季学会) (秋季学会), 152 - 152, Japanese全身静脈血サンプリングが診断に有用であった右手関節軟部腫瘍による腫瘍性骨軟化症の1例Research society
- Sep. 2013, INTERNATIONAL JOURNAL OF ONCOLOGY, 43(3) (3), 703 - 712, English[Refereed]Scientific journal
- (公社)日本整形外科学会, Aug. 2013, 日本整形外科学会雑誌, 87(8) (8), S1473 - S1473, JapaneseResearch society
- Osteosarcoma is the most common primary solid malignant bone tumor. Despite substantial improvements in surgery and chemotherapy, metastasis remains a major cause of fatal outcomes, and the molecular mechanisms of metastasis are still poorly understood. Hypoxia, which is common in malignant tumors including osteosarcoma, increases expressions of hypoxia inducible factor (HIF)-1α, matrix metalloproteinase (MMP)-2 and MMP-9, and can induce invasiveness. As we previously showed a novel transcutaneous CO2 application to decrease HIF-1α expression and induce apoptosis in malignant fibrous histiocytoma, we hypothesize that transcutaneous CO2 application could suppress metastatic potential of osteosarcoma by improving hypoxic conditions. Here, we examined the effects of transcutaneous CO2 application on apoptosis, and development of pulmonary metastasis using a highly metastatic osteosarcoma cell line, LM8. Transcutaneous CO2 application significantly decreased tumor growth and pulmonary metastasis in LM8 cells. Apoptotic activity increased, and intratumoral hypoxia was improved with decreased expressions of HIF-1α, MMP-2 and MMP-9, significantly, in the CO2-treated tumors. In conclusion, we found that transcutaneous CO2 application can induce tumor cell apoptosis and might suppress pulmonary metastasis by improvement of hypoxic conditions with decreased expressions of HIF-1α and MMPs in highly metastatic osteosarcoma cell. These findings strongly indicate that this novel transcutaneous CO2 therapy could be a therapeutic breakthrough for osteosarcoma patients.Aug. 2013, Experimental cell research, 319(13) (13), 1988 - 97, English, International magazine[Refereed]Scientific journal
- (公社)日本整形外科学会, Jun. 2013, 日本整形外科学会雑誌, 87(6) (6), S1111 - S1111, JapaneseResearch society
- (公社)日本整形外科学会, Jun. 2013, 日本整形外科学会雑誌, 87(6) (6), S1169 - S1169, JapaneseResearch society
- (公社)日本整形外科学会, Jun. 2013, 日本整形外科学会雑誌, 87(6) (6), S1242 - S1242, JapaneseResearch society
- (公社)日本整形外科学会, Jun. 2013, 日本整形外科学会雑誌, 87(6) (6), S1106 - S1106, JapaneseResearch society
- Jun. 2013, JOURNAL OF ULTRASOUND IN MEDICINE, 32(6) (6), 915 - 922, English[Refereed]Scientific journal
- (公社)日本整形外科学会, Jun. 2013, 日本整形外科学会雑誌, 87(6) (6), S1109 - S1109, JapaneseResearch society
- May 2013, The Japanese Journal of Rehabilitation Medicine, 50(Suppl.) (Suppl.), S361, Japanese乳癌細胞株を移植した動物モデルに対する経皮的炭酸ガス治療の効果Research society
- May 2013, The Japanese Journal of Rehabilitation Medicine, 50(Suppl.) (Suppl.), S409, Japanese大腿切断後の断端shrinkageに対し従来の吸着式ソケットにより良好な成績を得た1例Research society
- May 2013, The Japanese Journal of Rehabilitation Medicine, 50(Suppl.) (Suppl.), S361, Japanese骨肉腫肺転移マウスモデルに対する経皮炭酸ガス療法の効果の検討Research society
- May 2013, The Japanese Journal of Rehabilitation Medicine, 50(Suppl.) (Suppl.), S291, Japanese鏡視下腱板修復術に対する腕神経叢ブロックの術後疼痛への影響 Pain visionによる評価Research society
- (株)医学書院, Apr. 2013, 臨床整形外科, 48(4) (4), 429 - 432, Japanese大腿切断5年後に断端神経腫を発症した1例[Refereed]Scientific journal
- (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(2) (2), S323 - S323, JapaneseResearch society
- (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(3) (3), S720 - S720, JapaneseResearch society
- Mar. 2013, INTERNATIONAL ORTHOPAEDICS, 37(3) (3), 421 - 425, English[Refereed]Scientific journal
- Mar. 2013, Applied Radiation and Isotopes, 73, 96 - 100, English[Refereed]Scientific journal
- 2013, Book of Abstracts for 7th Young Researchers’ Boron Neutron Capture Therapy Meeting, 28 - 29, EnglishBoron neutron capture therapy (BNCT) as a new therapeutic approach for treatment of clear cell sarcoma (CCS): Basic study on a lung metastasis model of CCS for BNCTInternational conference proceedings
- Magnetic resonance imaging (MRI) plays an important role in the diagnosis of osteomyelitis, especially during the early phase of the disease. The findings of sequential MRIs during the course of treatment in acute osteomyelitis in children have not yet been reported in the literature. We present a case of acute epiphyseal osteomyelitis in the distal femur of an infant. We monitored imaging changes by sequential MRIs and radiographs. MRI was more useful than radiograph for early diagnosis and evaluation of therapeutic response.2013, Case reports in radiology, 2013, 672815 - 672815, English, International magazine[Refereed]Scientific journal
- Fibrous dysplasia (FD) is an uncommon, but well-known benign skeletal disorder. In cases affecting long bones, FD is commonly recognized to locate in the diaphyses or the metaphyses and to spare the epiphyses. In this paper, we present a rare case of polyostotic FD in a 13-year-old girl with unilateral multiple epiphyseal lesions arising in the femur, the tibia, and the fibula with the growth plates.2013, Case reports in orthopedics, 2013, 715402 - 715402, English, International magazine[Refereed]Scientific journal
- Dec. 2012, ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 28(12) (12), 1790 - 1799, English[Refereed]Scientific journal
- Dec. 2012, ORTHOPEDICS, 35(12) (12), E1711 - E1715, English[Refereed]Scientific journal
- Dec. 2012, 移植, 47(6号) (6号), 498 - 499, JapaneseiPS細胞の骨再生へ向けた新たな骨分化誘導法の確立[Refereed]Symposium
- Nov. 2012, PLOS ONE, 7(11) (11), e49189, English[Refereed]Scientific journal
- Nov. 2012, INTERNATIONAL ORTHOPAEDICS, 36(11) (11), 2243 - 2248, English[Refereed]Scientific journal
- Oct. 2012, INTERNATIONAL ORTHOPAEDICS, 36(10) (10), 2073 - 2077, English[Refereed]Scientific journal
- Oct. 2012, ORTHOPEDICS, 35(10) (10), E1476 - E1482, English[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Sep. 2012, 中部日本整形外科災害外科学会雑誌, 55(秋季学会) (秋季学会), 175 - 175, Japanese血管柄付腓骨移植を用いて再建した足根骨骨巨細胞腫の一例[Refereed]Research society
- Sep. 2012, Journal of Orthopaedic Science, 17(5) (5), 649 - 653, English[Refereed]Scientific journal
- Sep. 2012, JOURNAL OF FOOT & ANKLE SURGERY, 51(5) (5), 648 - 651, English[Refereed]Scientific journal
- (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1102 - S1102, Japanese炭酸ガス経皮投与療法を用いた骨・軟部肉腫に対する新しい治療法[Refereed]Research society
- (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1313 - S1313, Japanese[Refereed]Research society
- (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1102 - S1102, Japaneseミトコンドリア量調節による悪性骨・軟部腫瘍に対する治療の可能性[Refereed]Research society
- (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1380 - S1380, Japanese[Refereed]Research society
- Aug. 2012, ORTHOPEDICS, 35(8) (8), E1264 - E1266, English[Refereed]Scientific journal
- (公社)日本整形外科学会, Jun. 2012, 日本整形外科学会雑誌, 86(6) (6), S810 - S810, Japanese[Refereed]Research society
- (一社)日本移植学会, Jun. 2012, 移植, 47(2-3) (2-3), 246 - 246, Japanese良性骨腫瘍切除後骨欠損に対する高純度β-リン酸三カルシウム(β-TCP)充填の治療成績Research society
- (公社)日本整形外科学会, Jun. 2012, 日本整形外科学会雑誌, 86(6) (6), S969 - S969, Japanese[Refereed]Research society
- (公社)日本整形外科学会, Jun. 2012, 日本整形外科学会雑誌, 86(6) (6), S954 - S954, Japanese[Refereed]Research society
- (公社)日本整形外科学会, Jun. 2012, 日本整形外科学会雑誌, 86(6) (6), S823 - S823, Japanese[Refereed]Research society
- Jun. 2012, INTERNATIONAL JOURNAL OF ONCOLOGY, 40(6) (6), 1839 - 1848, English[Refereed]Scientific journal
- Jun. 2012, RHEUMATOLOGY INTERNATIONAL, 32(6) (6), 1691 - 1694, EnglishScientific journal
- (公社)日本整形外科学会, Jun. 2012, 日本整形外科学会雑誌, 86(6) (6), S970 - S970, Japanese[Refereed]Research society
- May 2012, The Japanese Journal of Rehabilitation Medicine, 49(Suppl.) (Suppl.), S268, Japanese骨肉腫細胞における酸素環境の変化に伴うマトリックスメタロプロテアーゼ2及び9の発現変化についての検討[Refereed]Research society
- (一社)日本小児血液・がん学会, May 2012, 日本小児血液・がん学会雑誌, 49(1-2) (1-2), 115 - 120, Japaneseタンデム自家造血細胞移植併用大量化学療法を施行後3年寛解を維持している初診時全身骨髄転移陽性Ewing肉腫ファミリー腫瘍の1例[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Apr. 2012, 中部日本整形外科災害外科学会雑誌, 55(春季学会) (春季学会), 139 - 139, Japanese胸壁発生の悪性軟部腫瘍に対する治療成績[Refereed]Research society
- Apr. 2012, JOURNAL OF SHOULDER AND ELBOW SURGERY, 21(4) (4), E1 - E4, English[Refereed]Scientific journal
- (公社)日本整形外科学会, Mar. 2012, 日本整形外科学会雑誌, 86(3) (3), S545 - S545, Japanese[Refereed]Research society
- 2012, Journal of Cancer Science and Therapy, 4(7) (7), 3 - 181, English[Refereed]Scientific journal
- 2012, JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT, 49(8) (8), 1255 - 1260, English[Refereed]Scientific journal
- 2012, Open Journal of Pathology, 2, 90 - 95, EnglishDedifferentiated chondrosarcoma with a high-grade mesenchymal component mimicking a gastrointestinal stromal tumor[Refereed]Scientific journal
- Fibroblast growth factor 23 (FGF23) was recently identified as an important factor involved in the development of hypophosphatemic rickets and osteomalacia. We experienced a rare case of acute prosthesis migration after hemihip arthroplasty due to FGF23-induced tumor. The patient underwent femoral head replacement because of femoral neck fracture, but prosthesis migration was occurred at 1 week after operation. The patient took various examinations, and FGF23-induced tumor was found in his right wrist. The tumor was resected, and he underwent total hip arthroplasty 8 month later. Finally, he was able to obtain free gait without pain.2012, Case reports in medicine, 2012, 503956 - 503956, English, International magazine[Refereed]Research institution
- 2012, Kobe Journal of Medical Sciences, 58(1) (1), E29 - E32, EnglishNontraumatic true aneurysm of the superficial palmar arch: A case report[Refereed]Scientific journal
- 2012, Kobe Journal of Medical Sciences, 58(3) (3), E82 - E85, EnglishSevere laceration of flexor tendons after locking palmar plate fixation of distal radius fracture: A case report[Refereed]Scientific journal
- Dec. 2011, INTERNATIONAL JOURNAL OF ONCOLOGY, 39(6) (6), 1545 - 1552, English[Refereed]Scientific journal
- Dec. 2011, APPLIED RADIATION AND ISOTOPES, 69(12) (12), 1713 - 1716, English[Refereed]Scientific journal
- Dec. 2011, APPLIED RADIATION AND ISOTOPES, 69(12) (12), 1721 - 1724, EnglishScientific journal
- (一社)中部日本整形外科災害外科学会, Nov. 2011, 中部日本整形外科災害外科学会雑誌, 54(6) (6), 1315 - 1315, Japanese大腿切断後に断端神経腫を発症した1例International conference proceedings
- Nov. 2011, ONCOLOGY REPORTS, 26(5) (5), 1221 - 1226, English[Refereed]Scientific journal
- (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1320 - S1320, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1260 - S1260, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1261 - S1261, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1321 - S1321, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2011, 日本整形外科学会雑誌, 85(6) (6), S891 - S891, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2011, 日本整形外科学会雑誌, 85(6) (6), S851 - S851, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2011, 日本整形外科学会雑誌, 85(6) (6), S844 - S844, JapaneseInternational conference proceedings
- Jun. 2011, 日本整形外科学会雑誌, 85巻, 6号, pp. S848-S848, Japanese悪性線維性組織球腫における増殖因子や細胞内シグナル伝達経路の働きInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2011, 日本整形外科学会雑誌, 85巻, 6号, pp. S922-S922(6) (6), S922 - S922, Japaneseホウ素中性子捕捉療法(BNCT)を用いた明細胞肉腫に対する新しい治療方法International conference proceedings
- (公社)日本整形外科学会, Jun. 2011, 日本整形外科学会雑誌, 85(6) (6), S937 - S937, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2011, 日本整形外科学会雑誌, 85(6) (6), S937 - S937, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2011, 日本整形外科学会雑誌, 85(6) (6), S936 - S936, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2011, 日本整形外科学会雑誌, 85(6) (6), S943 - S943, JapaneseInternational conference proceedings
- (公社)日本薬剤学会, May 2011, 日本薬剤学会年会講演要旨集26年会, 巻, , pp. 131-131, 131 - 131, Japanese明細胞肉腫におけるホウ素中性子捕捉療法用化合物の細胞内取込と体内動態International conference proceedings
- (公社)日本理学療法士協会, Apr. 2011, 理学療法学, 38(Suppl.2) (Suppl.2), PI1 - 206, Japanese悪性骨腫瘍に伴う大腿骨病的骨折に対して創外固定術後に腫瘍用人工膝関節置換術を施行した就学児童の一症例 自立歩行獲得までの経緯International conference proceedings
- (一社)中部日本整形外科災害外科学会, Mar. 2011, 中部日本整形外科災害外科学会雑誌, 54(春季学会) (春季学会), 179 - 179, Japanese幼児の大腿骨骨端部骨髄炎の一例 X線、MR所見の経時的変化International conference proceedings
- (公社)日本整形外科学会, Mar. 2011, 日本整形外科学会雑誌, 85(3) (3), S567 - S567, JapaneseInternational conference proceedings
- (公社)日本薬学会, Mar. 2011, 日本薬学会年会要旨集, 131年会(4) (4), 228 - 228, Japaneseホウ素中性子捕捉療法による明細胞肉腫の治療のためのL-BPAの細胞取込挙動および体内動態の評価International conference proceedings
- (公社)日本整形外科学会, Feb. 2011, 日本整形外科学会雑誌 85巻, 85(2) (2), S112 - S112, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Feb. 2011, 日本整形外科学会雑誌, 85(2) (2), S111 - S111, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Feb. 2011, 日本整形外科学会雑誌, 85(2) (2), S112 - S112, JapaneseInternational conference proceedings
- (NPO)日本小児がん学会, Dec. 2010, 小児がん, 47(プログラム・総会号) (プログラム・総会号), 302 - 302, Japaneseタンデム自家末梢血幹細胞移植後2年間寛解維持している初診時骨髄転移陽性Ewing肉腫の1例International conference proceedings
- Nov. 2010, UPSALA JOURNAL OF MEDICAL SCIENCES, 115(4) (4), 291 - 296, EnglishScientific journal
- Oct. 2010, SPINE, 35(21) (21), E1137 - E1140, English[Refereed]Scientific journal
- Oct. 2010, TISSUE ENGINEERING PART A, 16(10) (10), 3271 - 3284, English[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Sep. 2010, 中部日本整形外科災害外科学会雑誌, 53(秋季学会) (秋季学会), 39 - 39, Japanese後脛骨神経に発生したintraneural hemangiomaの1例International conference proceedings
- Sep. 2010, ANTICANCER RESEARCH, 30(9) (9), 3391 - 3395, EnglishThe Effect of Bevacizumab on Tumour Growth of Malignant Fibrous Histiocytoma in an Animal ModelScientific journal
- (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1184 - S1184, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1176 - S1176, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1184 - S1184, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1182 - S1182, JapaneseInternational conference proceedings
- 金原出版(株), Jul. 2010, 整形・災害外科, 53(8) (8), 1001 - 1005, Japanese上腕骨近位骨端部に発生したLangerhans cell hystiocytosisの1例[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Jul. 2010, 中部日本整形外科災害外科学会雑誌, 53(4) (4), 973 - 974, Japanese下垂足で発症した神経内ガングリオンの1例International conference proceedings
- (公社)日本整形外科学会, Jun. 2010, 日本整形外科学会雑誌, 84巻, 6号, pp. S978-S978(6) (6), S978 - S978, Japanese明細胞肉腫に対するホウ素中性子捕捉療法を用いた新たな治療方法開発の試みInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2010, 日本整形外科学会雑誌, 84(6) (6), S989 - S989, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2010, 日本整形外科学会雑誌, 84(6) (6), S974 - S974, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2010, 日本整形外科学会雑誌, 84(6) (6), S952 - S952, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2010, 日本整形外科学会雑誌, 84(6) (6), S850 - S850, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2010, 日本整形外科学会雑誌, 84(6) (6), S924 - S924, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2010, 日本整形外科学会雑誌, 84(6) (6), S974 - S974, JapaneseInternational conference proceedings
- (一社)中部日本整形外科災害外科学会, Mar. 2010, 中部日本整形外科災害外科学会雑誌, 53(春季学会) (春季学会), 240 - 240, Japanese化膿性関節炎をきたした骨端部Brodie膿瘍の2例International conference proceedings
- Mar. 2010, FOOT & ANKLE INTERNATIONAL, 31(3) (3), 251 - 253, EnglishScientific journal
- Feb. 2010, 脊椎脊髄ジャーナル, 23巻, 2号, pp. 147-151, JapanesePETが診断に有用であった坐骨神経内結節性筋膜炎の1例[Refereed]Scientific journal
- Hindawi Limited, 2010, Case Reports in Medicine, 2010, EnglishScientific journal
- 2010, Kobe Journal of Medical Sciences, 56(4) (4), E162 - E164, EnglishPyogenic granuloma in a finger of a rheumatoid arthritis patient[Refereed]Scientific journal
- Nov. 2009, 中部日本整形外科災害外科学会雑誌, 52巻, 6号, pp. 1466-1467, Japanese特発性膝関節血症の2症例[Refereed]Scientific journal
- Nov. 2009, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 37(6) (6), 1921 - 1927, EnglishFactors Affecting Prosthetic Rehabilitation Outcomes in Amputees of Age 60 Years and OverScientific journal
- Sep. 2009, 中部日本整形外科災害外科学会雑誌, 52巻, 秋季学会, pp. 31-31, Japanese高純度β-TCPを用いた良性骨腫瘍に対する術後成績International conference proceedings
- (公社)日本整形外科学会, Aug. 2009, 日本整形外科学会雑誌, 83(8) (8), S1247 - S1247, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Aug. 2009, 日本整形外科学会雑誌, 83(8) (8), S1248 - S1248, JapaneseInternational conference proceedings
- Jul. 2009, APPLIED RADIATION AND ISOTOPES, 67(7-8) (7-8), S355 - S358, EnglishScientific journal
- Jun. 2009, 日本整形外科学会雑誌, 83巻, 6号, pp. S970-S970, Japanese脱神経筋萎縮を伴った悪性末梢神経鞘腫瘍の2例International conference proceedings
- Jun. 2009, 日本整形外科学会雑誌, 83巻, 6号, pp. S898-S898, Japanese骨・軟部悪性腫瘍に対するsecond line化学療法としてのICE療法International conference proceedings
- (公社)日本整形外科学会, Jun. 2009, 日本整形外科学会雑誌, 83(6) (6), S964 - S964, Japanese激烈な坐骨神経痛を呈しPETにより検出しえた坐骨神経内結節性筋膜炎の1例[Refereed]International conference proceedings
- Jun. 2009, 日本整形外科学会雑誌, 83巻, 6号, pp. S968-S968, Japanese悪性軟部腫瘍との鑑別を要したchronic expanding hematomaの2例International conference proceedings
- Jun. 2009, 日本整形外科学会雑誌, 83巻, 6号, pp. S883-S883, Japanese悪性軟部腫瘍MFHにおけるスフィンゴシンキナーゼの発現および細胞増殖への検討International conference proceedings
- May 2009, 中部日本整形外科災害外科学会雑誌, 52巻, 3号, pp. 794-794, Japanese上腕骨近位骨端部に発生したランゲルハンス細胞組織球症の1例International conference proceedings
- (一社)中部日本整形外科災害外科学会, Mar. 2009, 中部日本整形外科災害外科学会雑誌, 52(2) (2), 513 - 513, Japanese診断に難渋した左下肢痛の1例[Refereed]International conference proceedings
- Mar. 2009, 中部日本整形外科災害外科学会雑誌, 52巻, 春季学会, pp. 208-208, Japanese悪性軟部腫瘍との鑑別を要したchronic expanding hematomaの2例International conference proceedings
- (公社)日本小児科学会, Feb. 2009, 日本小児科学会雑誌, 113巻, 2号, pp. 342-342(2) (2), 342 - 342, Japanese神戸大学小児科での多発型を含む骨肉腫7例の治療成績International conference proceedings
- Feb. 2009, RHEUMATOLOGY INTERNATIONAL, 29(4) (4), 455 - 458, English[Refereed]Scientific journal
- 2009, Cancer Therapy, 7(ISSUE A) (ISSUE A), 43 - 48, EnglishExpression of DcR3 in bone and soft tissue tumorsScientific journal
- 南江堂, Jan. 2009, 整形外科, 60巻, 1号, pp. 55-57(1) (1), 55 - 57, Japanese大腿骨開放骨折後に発生した骨内類表皮嚢胞腫の1例[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Jan. 2009, 中部日本整形外科災害外科学会雑誌, 52巻, 1号, pp. 253-253(1) (1), 253 - 253, JapanesePyogenic granulomaの1例International conference proceedings
- 2009, Kobe Journal of Medical Sciences, 55(1) (1), -E4, EnglishTreatment of subungual glomus tumor[Refereed]Scientific journal
- Sep. 2008, 中部日本整形外科災害外科学会雑誌, 51巻, 5号, pp. 909-910(5) (5), 909 - 910, Japanese手指に発生したglomus腫瘍[Refereed]Scientific journal
- Sep. 2008, 中部日本整形外科災害外科学会雑誌, 51巻, 秋季学会, pp. 215-215, JapaneseBenign Lipoblastomaの2例International conference proceedings
- Aug. 2008, 日本整形外科学会雑誌, 82巻, 8号, pp. S920-S920, Japanese骨・軟部腫瘍における分子・細胞標的 骨・軟部腫瘍におけるDcR3の検討International conference proceedings
- Aug. 2008, 日本整形外科学会雑誌, 82巻, 8号, pp. S1026-S1026, Japanese血管新生阻害剤bevacizumabの悪性線維性組織球腫(MFH)に対するin vivoでの効果International conference proceedings
- Aug. 2008, 日本整形外科学会雑誌, 82巻, 8号, pp. S1230-S1230, Japanese悪性骨・軟部腫瘍の脂質代謝経路におけるEDGレセプターおよびスフィンゴシンキナーゼの検討International conference proceedings
- Aug. 2008, AMERICAN JOURNAL OF SPORTS MEDICINE, 36(8) (8), 1519 - 1527, English[Refereed]Scientific journal
- (公社)日本整形外科学会, Jun. 2008, 日本整形外科学会雑誌, 82(6) (6), S777 - S777, Japaneseガドリニウム中性子捕捉療法を目指したMRIによる腫瘍細胞株へのMRI造影剤の付着取り込みの評価について
- Jun. 2008, 日本整形外科学会雑誌, 82巻, 6号, pp. S859-S859, Japanese大腿骨開放骨折後に発症したintraosseous epidermoid cystの1例International conference proceedings
- Jun. 2008, 日本整形外科学会雑誌, 82巻, 6号, pp. S832-S832, Japanese若年者骨・軟部悪性腫瘍に対する末梢血幹細胞移植を併用した超大量化学療法International conference proceedings
- Jun. 2008, 日本整形外科学会雑誌, 82巻, 6号, pp. S799-S799, Japanese骨・軟部腫瘍細胞株におけるsiRNAを用いたDcR3抑制効果International conference proceedings
- Jun. 2008, 日本整形外科学会雑誌, 82巻, 6号, pp. S805-S805, Japanese悪性骨・軟部腫瘍におけるEDGレセプターおよびスフィンゴシンキナーゼの発現の検討International conference proceedings
- Mar. 2008, 中部日本整形外科災害外科学会雑誌, 51巻, 2号, pp. 380-380, Japanese大腿骨開放骨折後に発生したintraosseous epidermoid cystの1例International conference proceedings
- Mar. 2008, 日本手の外科学会雑誌, 25巻, 1号, pp. S75-S75, Japanese術中体外照射と超音波を併用した前腕悪性腫瘍の治療International conference proceedings
- Mar. 2008, 中部日本整形外科災害外科学会雑誌, 51巻, 春季学会, pp. 72-72, Japanese手指に発生したグロームス腫瘍International conference proceedings
- Mar. 2008, 中部日本整形外科災害外科学会雑誌, 51巻, 春季学会, pp. 191-191, Japanese関節内血腫を来たした膝関節内神経鞘腫の1例International conference proceedings
- Mar. 2008, CLINICAL IMAGING, 32(2) (2), 147 - 151, English[Refereed]Scientific journal
- Mar. 2008, SKELETAL RADIOLOGY, 37(3) (3), 263 - 265, English[Refereed]Scientific journal
- Mar. 2008, ANTICANCER RESEARCH, 28(2A) (2A), 825 - 832, EnglishInhibition of PKCa activation in human bone and soft tissue sarcoma cells by the selective PKC inhibitor PKC412[Refereed]Scientific journal
- Jan. 2008, CLINICAL IMAGING, 32(1) (1), 73 - 76, English[Refereed]Scientific journal
- Jul. 2007, JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 29(7) (7), 435 - 439, EnglishHigh level of ezrin mRNA expression in an osteosarcoma biopsy sample with lung metastasis[Refereed]Scientific journal
- Mar. 2007, 中部日本整形外科災害外科学会雑誌, 50巻, 春季学会, pp. 108-108, 108 - 108, Japanese当科における腱鞘巨細胞腫の治療成績International conference proceedings
- Feb. 2007, OSTEOARTHRITIS AND CARTILAGE, 15(2) (2), 226 - 231, EnglishScientific journal
- Fibrous hamartoma of infancy (FHI) is a rare benign tumor, which usually occurs within the first year of life. It is characterized histopathologically by organoid patterns; fibrous, adipose, and myxoid mesenchymal tissues. We experienced a case of FHI in a 2-year-old female. FHI occurred in the left buttock. MRI scans showed mixed intensity on T1 and T2-weighted images, and heterogeneous enhancement of Gd-DTPA. MRI findings suggested adipose tissues, fibrous tissues, and myxoid tissues. Therefore we consider that MRI scans are useful for diagnosis of FHI. The treatment for FHI is a marginal excision, but incomplete excision of FHI results in recurrence. FHI often has unclear boundaries of its margins, so we recommend adequate surgical margins for excision.Japanese Society for Joint Diseases, 2007, Japanese Journal of Joint Diseases, 26(1) (1), 53 - 56, Japanese
- (株)南江堂, Jan. 2007, 整形外科, 58(1) (1), 31 - 33, Japanese正中神経に発生した蔓状神経鞘腫の1例[Refereed]Scientific journal
- Jan. 2007, ANTICANCER RESEARCH, 27(1A) (1A), 423 - 429, EnglishImatinib mesylate inhibits tumorigenicity of malignant fibrous histiocytoma cells in vivoScientific journal
- Nov. 2006, ANTICANCER RESEARCH, 26(6B) (6B), 4307 - 4311, EnglishExpression of VEGF and its receptors and angiogenesis in bone and soft tissue tumorsScientific journal
- Sep. 2006, 中部日本整形外科災害外科学会雑誌, 49巻, 秋季学会, pp. 62-62, JapaneseMRIで偶然に発見された初期骨梗塞International conference proceedings
- Aug. 2006, 日本整形外科学会雑誌, 80巻, 8号, pp. S1102-S1102, Japanese骨髄間葉系細胞に対するMRI造影剤の影響International conference proceedings
- Aug. 2006, 日本整形外科学会雑誌, 80巻, 8号, pp. S950-S950, Japanese骨・軟部腫瘍におけるDcR3発現の検討International conference proceedings
- Jun. 2006, 日本整形外科学会雑誌, 80巻, 6号, pp. S605-S605, Japanese骨巨細胞腫の治療戦略 骨巨細胞腫の治療成績International conference proceedings
- (公社)日本整形外科学会, Jun. 2006, 日本整形外科学会雑誌, 80(6) (6), S696 - S696, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2006, 日本整形外科学会雑誌, 80(6) (6), S695 - S695, JapaneseScientific journal
- (公社)日本整形外科学会, Jun. 2006, 日本整形外科学会雑誌, 80(6) (6), S703 - S703, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2006, 日本整形外科学会雑誌, 80(6) (6), S694 - S694, JapaneseInternational conference proceedings
- Jun. 2006, 日本整形外科学会雑誌, 80巻, 6号, pp. S702-S702, JapaneseMRI造影剤のイヌの骨髄間葉系細胞に対する影響についてInternational conference proceedings
- Mar. 2006, 中部日本整形外科災害外科学会雑誌, 49巻, 春季学会, pp.175-175, Japanese骨巨細胞腫の治療成績International conference proceedings
- (一社)中部日本整形外科災害外科学会, Nov. 2005, 中部日本整形外科災害外科学会雑誌, 48(6) (6), 1092 - 1092, Japanese正中神経に発生したplexiform schwannomaの1例International conference proceedings
- (一社)中部日本整形外科災害外科学会, Oct. 2005, 中部日本整形外科災害外科学会雑誌, 48(秋季学会) (秋季学会), 156 - 156, Japanese足趾に発生した骨外性軟骨腫の2例International conference proceedings
- Sep. 2005, Injury Extra, 36(9) (9), 402 - 404, English[Refereed]Scientific journal
- Sep. 2005, Radiation Medicine - Medical Imaging and Radiation Oncology, 23(6) (6), 398 - 406, EnglishThree-dimensional images of contrast-enhanced MDCT for preoperative assessment of musculoskeletal masses: Comparison with MRI and plain radiographs[Refereed]Scientific journal
- (公社)日本整形外科学会, Aug. 2005, 日本整形外科学会雑誌, 79(8) (8), S895 - S895, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2005, 日本整形外科学会雑誌, 79(6) (6), S560 - S560, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2005, 日本整形外科学会雑誌, 79(6) (6), S584 - S584, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2005, 日本整形外科学会雑誌, 79(6) (6), S611 - S611, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2005, 日本整形外科学会雑誌, 79(6) (6), S704 - S704, JapaneseInternational conference proceedings
- Apr. 2005, 中部日本整形外科災害外科学会雑誌, 48巻, 春季学会, pp.75-75, Japanese左環指に発生した滑膜性骨軟骨腫症の一例International conference proceedings
- (公社)日本整形外科学会, Mar. 2005, 日本整形外科学会雑誌, 79(3) (3), S193 - S193, JapaneseInternational conference proceedings
- Mar. 2005, 中部日本整形外科災害外科学会雑誌, 48巻, 2号, pp. 405-405, JapaneseBicipitoradial bursitis(上腕二頭筋腱橈骨滑液包炎)と鑑別が困難であった粘液腫の1例International conference proceedings
- Feb. 2005, PATHOLOGY INTERNATIONAL, 55(2) (2), 41 - 47, EnglishEstablishment and characterization of a KIT-positive and stem cell factor-producing cell line, KTHOS, derived from human osteosarcoma[Refereed]Scientific journal
- Feb. 2005, CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, Vol. , No. 431, pp. 241-244(431) (431), 241 - 244, English[Refereed]Scientific journal
- 足趾に発生した比較的稀な骨外性軟骨腫の2例を経験したので報告する。中部日本整形外科災害外科学会, 2005, 中部日本整形外科災害外科学会学術集会 抄録集, 105(0) (0), 348 - 348, Japanese
[症例] 症例１は19歳の男性。半年前より徐々に増大する左足趾の軟部腫瘤を自覚していた。初診時、左第４趾尖端部に径10mm大の弾性硬、境界明瞭な有痛性の腫瘤を触知した。症例２は64歳の女性。２年前より左母趾の軟部腫瘤に気付くも放置していた。初診時に左母趾末節部内側に同様の径15mm大の境界明瞭な腫瘤を触知した。２例とも、単純Ｘ線像では末節骨と連続性の無い円形の石灰化像を認め、MRIでは腫瘍辺縁部はT2強調画像にて高信号、腫瘍中心部はT1, T2強調画像にて低信号から中等度の信号を呈した。切除術を施行したところ共に末節骨と連続性の無い白色の表面平滑な球状の腫瘍を認めた。病理組織学的検査にて異型性の無い軟骨組織の中央部に骨化を認め、骨外性軟骨腫と診断した。
[考察] Enzingerは、軟部に発生した良性軟骨性病変を骨外性軟骨腫として、骨膜より発生する軟骨腫と区別している。好発部位は手指と足趾が大部分を占め、発症年齢は30歳から60歳とされている。鑑別診断として骨膜性軟骨腫、爪下外骨腫、異所性骨化、傍骨骨軟骨異形増生、軟骨肉腫などが挙げられるが、今回の症例では術前の診断に難渋した。本症例の様に画像所見にて骨との連続性が無く、比較的緩徐な発育を示す足趾の軟部に発生した小さな腫瘍では、骨外性軟骨腫も念頭において診断する必要があると思われた。 - Oct. 2004, 中部日本整形外科災害外科学会雑誌, 47巻, 秋季学会, pp. 61-61, Japanese手指に発生した多発腱鞘巨細胞腫の2例International conference proceedings
- Sep. 2004, ANTICANCER RESEARCH, 24(5D) (5D), 3514 - 3514, EnglishESTABLISHMENT AND CHARACTERIZATION OF A C-KIT POSITIVE AND SCF-PRODUCING CELL LINE, KTHOS, DERIVED FROM HUMAN OSTEOSARCOMA[Refereed]
- Sep. 2004, ANTICANCER RESEARCH, 24(5D) (5D), 3673 - 3674, EnglishEXPRESSION OF GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR FAMILY IN PERIPHERAL NERVE SHEATH TUMORS[Refereed]
- Sep. 2004, ANTICANCER RESEARCH, 24(5A) (5A), 2675 - 2679, EnglishInhibitory effect of ST1571 on cell proliferation of human malignant fibrous histiocytoma cell lines[Refereed]Scientific journal
- Sep. 2004, CLINICAL CANCER RESEARCH, 10(17) (17), 5804 - 5807, EnglishExpression of transforming growth factor beta isoforms and their receptors in malignant fibrous histiocytoma of soft tissues[Refereed]Scientific journal
- (一社)日本癌治療学会, Sep. 2004, 日本癌治療学会誌, 39(2) (2), 259 - 259, Japanese骨軟部腫瘍治療の現状と近未来 軟部肉腫における細胞増殖因子の発現とチロシンキナーゼ阻害剤の細胞増殖抑制作用International conference proceedings
- Aug. 2004, ORTHOPEDICS, 27(8) (8), 869 - 871, EnglishBilateral naviculocuneiform coalitions: Using multi-planar reconstruction computed tomography[Refereed]Scientific journal
- (公社)日本整形外科学会, Aug. 2004, 日本整形外科学会雑誌, 78(8) (8), S1099 - S1099, JapaneseInternational conference proceedings
- (一社)中部日本整形外科災害外科学会, Jul. 2004, 中部日本整形外科災害外科学会雑誌, 47(4) (4), 841 - 841, Japanese骨軟骨腫による上腕二頭筋長頭腱炎の1例International conference proceedings
- Jul. 2004, CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, Vol. , No. 424, pp. 191-193(424) (424), 191 - 193, English[Refereed]Scientific journal
- Jun. 2004, 日本整形外科学会雑誌, 78巻, 6号, pp. S702-S702, Japanese良性骨腫瘍切除後の骨欠損にたいする高純度b-TCP充填術の術後成績International conference proceedings
- (公社)日本整形外科学会, Jun. 2004, 日本整形外科学会雑誌, 78(6) (6), S607 - S607, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2004, 日本整形外科学会雑誌, 78(6) (6), S601 - S601, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2004, 日本整形外科学会雑誌, 78(6) (6), S675 - S675, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2004, 日本整形外科学会雑誌, 78(6) (6), S660 - S660, JapaneseInternational conference proceedings
- Jun. 2004, Skeletal Radiology, Vol. 33, No. 12, pp. 737-740, 737 - 740, EnglishApophysitis of the ischial tuberosity mimicking a neoplasm on magnetic resonance imaging[Refereed]Scientific journal
- May 2004, ANTICANCER RESEARCH, 24(3B) (3B), 2007 - 2010, EnglishExpression of betacellulin, heparin-binding epidermal growth factor and epiregulin in human malignant fibrous histiocytoma[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Mar. 2004, 中部日本整形外科災害外科学会雑誌, 47(2) (2), 370 - 371, Japanese若年者の大腿部に発生した孤立性線維性腫瘍の1例International conference proceedings
- Mar. 2004, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 68A(3) (3), 531 - 536, English[Refereed]Scientific journal
- Mar. 2004, ANTICANCER RESEARCH, 24(2C) (2C), 1307 - 1310, EnglishAmphiregulin and epidermal growth factor receptor expression in human malignant fibrous histiocytoma of soft tissues[Refereed]Scientific journal
- John Wiley and Sons Inc., Feb. 2004, Journal of Biomedical Materials Research - Part A, 68(3) (3), 531 - 536, English[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Feb. 2004, 中部日本整形外科災害外科学会雑誌, 47(春季学会) (春季学会), 164 - 164, JapanesePhalangeal Microgeodic Syndromeの2例International conference proceedings
- Feb. 2004, SKELETAL RADIOLOGY, 33(2) (2), 107 - 111, English[Refereed]Scientific journal
- Feb. 2004, FOOT & ANKLE INTERNATIONAL, 25(2) (2), 107 - 111, EnglishNeurilemmoma in the foot as a cause of heel pain: A report of two cases[Refereed]Scientific journal
- 2004, PATHOLOGY RESEARCH AND PRACTICE, 200(5) (5), 397 - 402, English[Refereed]Scientific journal
- (株)医学書院, Oct. 2003, 臨床整形外科, 38(10) (10), 1331 - 1334, Japanese透析患者の手指MP関節に発症したアミロイド関節炎の1例[Refereed]Scientific journal
- Oct. 2003, JOURNAL OF PEDIATRIC SURGERY, 38(10) (10), 1540 - 1542, English[Refereed]Scientific journal
- Sep. 2003, JOURNAL OF ARTHROPLASTY, 18(6) (6), 784 - 791, English[Refereed]Scientific journal
- Sep. 2003, ANTICANCER RESEARCH, 23(5B) (5B), 4325 - 4328, EnglishImmunohistochemical analysis of platelet-derived growth factor and its receptors in soft tissue malignant fibrous histiocytoma[Refereed]Scientific journal
- Sep. 2003, ANTICANCER RESEARCH, 23(5B) (5B), 4305 - 4308, EnglishExpression of stem cell factor and lack of c-kit expression in malignant fibrous histiocytoma of soft tissues[Refereed]Scientific journal
- (公社)日本整形外科学会, Aug. 2003, 日本整形外科学会雑誌, 77(8) (8), S1155 - S1155, JapaneseInternational conference proceedings
- Aug. 2003, 日本整形外科学会雑誌, 77巻, 8号, pp. S949-S949, Japanese機械的刺激とチタン合金粒子刺激によるマクロファージ様細胞のPGE2産生への影響International conference proceedings
- (公社)日本整形外科学会, Aug. 2003, 日本整形外科学会雑誌, 77(8) (8), S1125 - S1125, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Aug. 2003, 日本整形外科学会雑誌, 77(8) (8), S1155 - S1155, JapaneseInternational conference proceedings
- (一社)中部日本整形外科災害外科学会, Jul. 2003, 中部日本整形外科災害外科学会雑誌, 46(4) (4), 763 - 763, Japanese大腿骨に発生した骨膜性骨芽細胞腫の1例International conference proceedings
- Jul. 2003, CLINICAL NUCLEAR MEDICINE, 28(7) (7), 613 - +, EnglishUnusual TI-201 scintigraphic findings in intralesional hemorrhagic schwannoma of the knee[Refereed]Scientific journal
- Jul. 2003, JOURNAL OF SHOULDER AND ELBOW SURGERY, 12(4) (4), 408 - 410, English[Refereed]Scientific journal
- Jun. 2003, Journal of Rheumatology, 30(6) (6), 1351 - 1353, English, International magazineSubcutaneous, intramuscular, and intraosseous synovial cyst formation around the knee in rheumatoid arthritis/systemic lupus erythematosus overlap syndrome[Refereed]Scientific journal
- (公社)日本整形外科学会, Jun. 2003, 日本整形外科学会雑誌, 77(6) (6), S775 - S775, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2003, 日本整形外科学会雑誌, 77(6) (6), S750 - S750, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2003, 日本整形外科学会雑誌, 77(6) (6), S740 - S740, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2003, 日本整形外科学会雑誌, 77(6) (6), S830 - S830, JapaneseInternational conference proceedings
- May 2003, 整形外科, 54巻, 5号, pp. 535-537, JapaneseSynovitis-acne-pustulosis-hyperostosis-osteomyelitis(SAPHO)syndromeの2例[Refereed]Scientific journal
- May 2003, JOURNAL OF RHEUMATOLOGY, 30(5) (5), 1097 - 1099, EnglishAcute synovial rupture of the rheumatoid knee presenting as a pretibial mass: MRI appearance[Refereed]Scientific journal
- May 2003, ANTICANCER RESEARCH, 23(3B) (3B), 2329 - 2333, EnglishExpression of stem cell factor and c-kit in human malignant fibrous histiocytoma cell line (TNMY1)[Refereed]Scientific journal
- Apr. 2003, CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, Vol. , No. 409, pp. 151-157(409) (409), 151 - 157, English[Refereed]Scientific journal
- Mar. 2003, Diagnostic Cytopathology, 28(3) (3), 159 - 162, English, International magazine[Refereed]Scientific journal
- Feb. 2003, JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 85A(2) (2), 343 - 345, EnglishDumbbell-shaped iliopsoas bursitis penetrating the pelvic wall: A rare complication of hip arthrodesis - A case report[Refereed]Scientific journal
- 2003, Arthroscopy, 19(2) (2), XXI - XXII, English[Refereed]Scientific journal
- Jan. 2003, CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, (406) (406), 214 - 217, English[Refereed]Scientific journal
- Jan. 2003, ANTICANCER RESEARCH, 23(1B) (1B), 793 - 797, EnglishFine-needle aspiration biopsy in the initial diagnosis of bone lesions[Refereed]Scientific journal
- Jan. 2003, Anticancer Research, 23(1 B) (1 B), 799 - 802Management of liposarcoma occurring in pregnant women[Refereed]Scientific journal
- Dec. 2002, DIAGNOSTIC CYTOPATHOLOGY, 27(6) (6), 354 - 361, English[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Nov. 2002, 中部日本整形外科災害外科学会雑誌, 45(6) (6), 1075 - 1076, Japanese膝関節包より発生した腱鞘線維腫の2例
- Nov. 2002, PATHOLOGY INTERNATIONAL, 52(11) (11), 730 - 733, EnglishNeural fibrolipoma of the superficial peroneal nerve in the ankle: A case report with immunohistochemical analysis[Refereed]Scientific journal
- Nov. 2002, ANTICANCER RESEARCH, 22(6B) (6B), 3561 - 3567, EnglishScrape and fine-needle aspiration cytology of elastofibroma[Refereed]Scientific journal
- Nov. 2002, Anticancer Research, 22(6 B) (6 B), 3685 - 3690Reimplantation of autoclaved or irradiated cortical bones invaded by soft tissue sarcomas[Refereed]Scientific journal
- Sep. 2002, DIAGNOSTIC CYTOPATHOLOGY, 27(3) (3), 177 - 180, English[Refereed]Scientific journal
- Sep. 2002, CLINICAL IMAGING, 26(5) (5), 314 - 318, EnglishSubacute osteomyelitis of long bones - Diagnostic usefulness of the "penumbra sign" on MRI[Refereed]Scientific journal
- Jul. 2002, CLINICAL IMAGING, 26(4) (4), 280 - 283, EnglishFibroma of tendon sheath originating from the knee joint capsule[Refereed]Scientific journal
- Jul. 2002, CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, (400) (400), 165 - 173, EnglishHistologic evaluation of posterior cruciate ligaments from osteoarthritic knees[Refereed]Scientific journal
- Jun. 2002, AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 26(6) (6), 804 - 808, English[Refereed]Scientific journal
- May 2002, JOURNAL OF RHEUMATOLOGY, 29(5) (5), 1100 - 1101, EnglishLumbar spondylodiscitis in SAPHO syndrome: Multimodality Imaging findings[Refereed]Scientific journal
- Mar. 2002, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 59(3) (3), 507 - 515, EnglishThe effect of particle wear debris on NF kappa B activation and pro-inflammatory cytokine release in differentiated THP-1 cells[Refereed]Scientific journal
- Feb. 2002, DIAGNOSTIC CYTOPATHOLOGY, 26(2) (2), 109 - 112, English[Refereed]Scientific journal
- Feb. 2002, JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 84A(2) (2), 226 - 235, EnglishAlendronate does not inhibit early bone apposition to hydroxyapatite-coated total joint implants - A preliminary study[Refereed]Scientific journal
- THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, 2002, 中部日本整形外科災害外科学会雑誌, 45(4) (4), 701 - 702, Japanese
- THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, 2002, The Central Japan Journal of Orthopaedic Surgery & Traumatology, 45(3) (3), 413 - 414, Japanese
- W.B. Saunders, 2002, Arthroscopy - Journal of Arthroscopic and Related Surgery, 18(5) (5), XV - XVIb, English[Refereed]Scientific journal
- Jan. 2002, JOURNAL OF HAND SURGERY-AMERICAN VOLUME, 27A(1) (1), 160 - 164, English[Refereed]Scientific journal
- Jan. 2002, JOURNAL OF SHOULDER AND ELBOW SURGERY, 11(1) (1), 92 - 94, English[Refereed]Scientific journal
- Nov. 2001, CLINICAL IMAGING, 25(6) (6), 428 - 431, EnglishIntraosseous lipoma of the humeral head - MR appearance[Refereed]Scientific journal
- Sep. 2001, CLINICAL IMAGING, 25(5) (5), 368 - 372, EnglishOssified intramuscular hemangioma: Multimodality imaging findings[Refereed]Scientific journal
- Sep. 2001, JOURNAL OF RHEUMATOLOGY, 28(9) (9), 2136 - 2138, EnglishOsteoarthropathy associated with Weber-Christian disease[Refereed]Scientific journal
- Aug. 2001, PATHOLOGY INTERNATIONAL, 51(8) (8), 595 - 602, EnglishEstablishment and characterization of cell line TNMY1 derived from human malignant fibrous histiocytoma[Refereed]Scientific journal
- Jun. 2001, CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, (387) (387), 127 - 131, EnglishElastofibroma in shoulder osteoarthritis - A theoretical concept of the etiology[Refereed]Scientific journal
- Apr. 2001, JOURNAL OF ARTHROPLASTY, 16(3) (3), 389 - 393, EnglishParatibial cyst associated with wear debris after total knee arthroplasty[Refereed]Scientific journal
- Mar. 2001, ARTHROSCOPY, 17(3) (3), 264 - 269, English[Refereed]Scientific journal
- Aug. 2000, SKELETAL RADIOLOGY, 29(8) (8), 470 - 473, EnglishSolid aneurysmal bone cyst in the humerus[Refereed]Scientific journal
- Apr. 2000, JOURNAL OF ARTHROPLASTY, 15(3) (3), 305 - 313, EnglishThe spatial location of impingement in total hip arthroplasty[Refereed]Scientific journal
- Dec. 1999, JOURNAL OF ARTHROPLASTY, 14(8) (8), 1011 - 1018, EnglishMultidirectional deformation in fully congruent acetabular components[Refereed]Scientific journal
- Oct. 1999, JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 81A(10) (10), 1446 - 1449, EnglishEarly osteolysis following total hip arthroplasty with use of a hylamer liner in combination with a modular ceramic femoral head - A case report[Refereed]Scientific journal
- Sep. 1999, JOURNAL OF ORTHOPAEDIC RESEARCH, 17(5) (5), 695 - 702, EnglishPolyethylene wear vector in vivo: A three-dimensional analysis using retrieved acetabular components and radiographs[Refereed]Scientific journal
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- Jan. 1998, FEBS Letters, 422(1) (1), 108 - 112, English[Refereed]Scientific journal
- Elsevier B.V., Jun. 1996, FEBS Letters, 387(2-3) (2-3), 141 - 144, English[Refereed]Scientific journal
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- (一社)中部日本整形外科災害外科学会, Mar. 2023, 中部日本整形外科災害外科学会雑誌, 66(春季学会) (春季学会), 305 - 305, Japanese足趾に生じた粘液型脂肪肉腫の一例
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- (一社)中部日本整形外科災害外科学会, Oct. 2022, 中部日本整形外科災害外科学会雑誌, 65(5) (5), 262 - 262, Japanese軟骨肉腫との鑑別を要した骨盤軟骨粘液線維腫の一例Meeting report
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- 日本公衆衛生学会, Sep. 2022, 日本公衆衛生学会総会抄録集, 81回, 234 - 234, Japanese高齢者肺炎球菌ワクチンの接種率および接種関連要因の検討 LIFE Study
- (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1761 - S1761, Japanese
- (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1761 - S1761, Japanese
- Last, (一社)中部日本整形外科災害外科学会, Sep. 2022, 中部日本整形外科災害外科学会雑誌, 65(5) (5), 746 - 746, Japanese内軟骨腫との鑑別を要した小児中足骨発生の類上皮血管内皮腫の1例Meeting report
- (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1761 - S1761, Japanese
- (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1761 - S1761, Japanese
- (公社)大阪府理学療法士会, Jun. 2022, 大阪府理学療法学術大会学会誌, 34, 98 - 98, Japanese前十字靱帯再損傷と恐怖心の関連【卒業研究】
- (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1300 - S1300, Japanese
- (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1346 - S1346, Japanese
- (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1348 - S1348, Japanese
- (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1352 - S1352, Japanese
- (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1356 - S1356, Japanese
- (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1371 - S1371, Japanese
- (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1428 - S1428, Japanese
- (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1432 - S1432, Japanese
- (公社)大阪府理学療法士会, Jun. 2022, 大阪府理学療法学術大会学会誌, 34, 98 - 98, Japanese前十字靱帯再損傷と恐怖心の関連【卒業研究】
- (公社)日本リハビリテーション医学会, May 2022, The Japanese Journal of Rehabilitation Medicine, (特別号) (特別号), S274 - S274, Japaneseキャンサーボードを用いた骨転移患者診療の経時的変化
- (公社)日本リハビリテーション医学会, May 2022, The Japanese Journal of Rehabilitation Medicine, (特別号) (特別号), S642 - S642, Japanese両大腿骨切迫骨折に対し、両側髄内定固定術を施行された一症例
- (一社)中部日本整形外科災害外科学会, Apr. 2022, 中部日本整形外科災害外科学会雑誌, 65(春季学会) (春季学会), 123 - 123, Japanese手足に生じた軟部肉腫の予後に関する検討
- (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S113 - S113, Japanese
- (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S886 - S886, Japanese
- (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S113 - S113, Japanese
- (一社)日本理学療法学会連合, Dec. 2021, 理学療法学, 48(Suppl.1) (Suppl.1), [2G6 - 01], Japaneseラット変形性膝関節症に対する経皮的炭酸ガス療法の効果
- (一社)日本理学療法学会連合, Dec. 2021, 理学療法学, 48(Suppl.1) (Suppl.1), [2G25 - 02], Japanese炭酸ガスペースト(ディレコート)による人工Bohr効果の検証
- (一社)中部日本整形外科災害外科学会, Sep. 2021, 中部日本整形外科災害外科学会雑誌, 64(秋季学会) (秋季学会), 235 - 235, Japanese慢性再発性多発性骨髄炎の一例
- (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1551 - S1551, Japanese
- (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1621 - S1621, Japanese
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1273 - S1273, Japanese
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1295 - S1295, Japanese
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1319 - S1319, Japanese
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1343 - S1343, Japanese
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1352 - S1352, Japanese
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1364 - S1364, Japanese
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1396 - S1396, Japanese
- (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S897 - S897, Japanese
- (公社)日本理学療法士協会, Mar. 2021, 理学療法学, 47(Suppl.1) (Suppl.1), 174 - 174, Japanese経皮的炭酸ガス吸収療法がヒト骨格筋および関節可動域に及ぼす影響
- (公社)日本理学療法士協会, Mar. 2021, 理学療法学, 47(Suppl.1) (Suppl.1), 19 - 19, Japanese特発性正常圧水頭症の転倒関連因子の検討 歩行変動性とバランス機能に着目して
- 2021, 中部日本整形外科災害外科学会雑誌, 64肩関節周囲に生じた巨大な結節性偽痛風の1例
- (公社)日本リハビリテーション医学会, Nov. 2020, The Japanese Journal of Rehabilitation Medicine, 57(秋季特別号) (秋季特別号), S195 - S195, Japaneseがんロコモとリハビリテーション医学・医療 がんロコモと骨転移
- (公社)日本リハビリテーション医学会, Nov. 2020, The Japanese Journal of Rehabilitation Medicine, 57(秋季特別号) (秋季特別号), S307 - S307, Japanese骨転移キャンサーボードを用いたリハビリテーション治療における患者QOLに影響を与える因子の検討
- (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 95 - 95, Japanese寛骨臼の転移性骨腫瘍に対して骨セメント充填及びスクリューによる内固定を行った2例
- (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1861 - S1861, Japanese
- (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1982 - S1982, Japanese
- (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1856 - S1856, JapaneseEwing肉腫におけるcellular dormancyの同定とその特性の探索
- (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1861 - S1861, Japanese乳癌骨転移における骨破壊に寄与するmiRNAの探索
- (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1982 - S1982, Japanese遺伝子導入による人工骨肉腫幹細胞株の樹立
- (一社)日本インターベンショナルラジオロジー学会, Aug. 2020, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 130 - 130, Japanese骨転移疼痛に対する集学的治療 -この痛みをどう治療するか- 転移性骨腫瘍に対する外科的治療
- (NPO)日本緩和医療学会, Aug. 2020, Palliative Care Research, 15(Suppl.) (Suppl.), S71 - S71, Japaneseがんロコモ 緩和ケアとがんロコモ
- (一社)日本インターベンショナルラジオロジー学会, Aug. 2020, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 130 - 130, Japanese骨転移疼痛に対する集学的治療 -この痛みをどう治療するか- 転移性骨腫瘍に対する外科的治療
- (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 3 - 2, Japanese頸椎転移患者の手術成績と成績不良因子の検討 PS、QOLの推移から
- (公社)日本整形外科学会, Jul. 2020, 日本整形外科学会雑誌, 94(6) (6), S1449 - S1449, Japanese
- (公社)日本整形外科学会, Jul. 2020, 日本整形外科学会雑誌, 94(6) (6), S1525 - S1525, Japanese
- (公社)日本整形外科学会, Jul. 2020, 日本整形外科学会雑誌, 94(6) (6), S1546 - S1546, Japanese
- (公社)日本整形外科学会, Jul. 2020, 日本整形外科学会雑誌, 94(6) (6), S1548 - S1548, Japanese
- (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 240 - 240, Japanese前腕に発生した悪性グロームス腫瘍の1例
- (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(2) (2), S338 - S338, Japanese悪性軟部腫瘍肺転移に対する肺転移切除の意義
- (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1040 - S1040, Japanese
- (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1679 - S1679, Japaneseリプログラミング因子を用いた人工骨肉腫幹細胞株の樹立とその特性の探索
- (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1957 - S1957, Japaneseがん骨転移における骨破壊に寄与するmiRNAの同定
- (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1679 - S1679, Japaneseリプログラミング因子を用いた人工骨肉腫幹細胞株の樹立とその特性の探索
- (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1957 - S1957, Japaneseがん骨転移における骨破壊に寄与するmiRNAの同定
- (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(秋季学会) (秋季学会), 234 - 234, Japanese発熱性好中球減少症と鑑別を要したG‐CSF投与による大動脈炎の1例
- (一社)日本物理療法学会, Aug. 2019, 物理療法科学, 26, 16 - 20, Japanese
- (公社)日本理学療法士協会, Aug. 2019, 理学療法学, 46(Suppl.1) (Suppl.1), 1 - 8, Japanese関節固定後の関節拘縮に対する経皮的炭酸ガス吸収療法の予防・治療効果
- (NPO)日本緩和医療学会, Jun. 2019, Palliative Care Research, 14(Suppl.) (Suppl.), S230 - S230, Japaneseがん性疼痛に対する経皮的電気刺激治療(TENS)の効果の検討
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1350 - S1350, Japanese右足部軟部腫瘍の1例
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1361 - S1361, Japanese骨巨細胞腫に対する治療成績
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1368 - S1368, Japanese手指、足趾発生の腱鞘巨細胞腫に対する治療成績
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1373 - S1373, JapaneseWait & see policyで初回治療を行った腹腔外デスモイド型線維腫症の検討
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1422 - S1422, Japanese明細胞肉腫に対するLAT1阻害剤の抗腫瘍効果の検討
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1485 - S1485, Japanese骨肉腫に対する徐放化抗癌剤抱合血管内皮前駆細胞を用いた新規がん治療法の開発
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1497 - S1497, Japanese粘液型脂肪肉腫の治療成績
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1514 - S1514, Japanese坐骨神経近傍に発生した悪性筋上皮腫の1例
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1516 - S1516, Japanese骨・軟部肉腫における脳転移症例の検討
- 日本運動器科学会, Jun. 2019, 運動器リハビリテーション, 30(2) (2), 179 - 179, Japanese大腿骨近位部病的骨折 人工関節の適応と限界
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1350 - S1350, Japanese右足部軟部腫瘍の1例
- 日本運動器科学会, Jun. 2019, 運動器リハビリテーション, 30(2) (2), 179 - 179, Japanese大腿骨近位部病的骨折:人工関節の適応と限界
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1361 - S1361, Japanese骨巨細胞腫に対する治療成績
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1485 - S1485, Japanese骨肉腫に対する徐放化抗癌剤抱合血管内皮前駆細胞を用いた新規がん治療法の開発
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1368 - S1368, Japanese手指,足趾発生の腱鞘巨細胞腫に対する治療成績
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1373 - S1373, JapaneseWait & see policyで初回治療を行った腹腔外デスモイド型線維腫症の検討
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1422 - S1422, Japanese明細胞肉腫に対するLAT1阻害剤の抗腫瘍効果の検討
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1416 - S1416, Japaneseリプログラミング因子を用いた人工骨肉腫幹細胞株の樹立
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1497 - S1497, Japanese粘液型脂肪肉腫の治療成績
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1514 - S1514, Japanese坐骨神経近傍に発生した悪性筋上皮腫の1例
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1516 - S1516, Japanese骨・軟部肉腫における脳転移症例の検討
- (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 1 - 5, Japaneseがんの骨転移症例に対するリハビリテーション医療の現状と症例検討
- (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 2 - 2, Japaneseラット腱板修復術モデルに対するbFGFおよびPRP同時投与の有効性の検討
- (一社)中部日本整形外科災害外科学会, May 2019, 中部日本整形外科災害外科学会雑誌, 62(3) (3), 595 - 595, Japanese膝関節軟骨穿破を伴ったBrodie膿瘍を長期経過観察した1例
- (一社)中部日本整形外科災害外科学会, May 2019, 中部日本整形外科災害外科学会雑誌, 62(3) (3), 599 - 600, Japanese膝関節軟骨穿破を伴ったBrodie膿瘍を長期経過観察した1例
- (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 1 - 9, English四肢転移性骨腫瘍に対する外科的治療成績について
- (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 1 - 9, Japaneseがんの骨転移症例に対するリハビリテーション医療の現状と症例検討
- (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 2 - 12, Japaneseラット腱板修復術モデルに対するbFGFおよびPRP同時投与の有効性の検討
- (一社)中部日本整形外科災害外科学会, May 2019, 中部日本整形外科災害外科学会雑誌, 62(3) (3), 595 - 595, Japanese膝関節軟骨穿破を伴ったBrodie膿瘍を長期経過観察した1例
- (一社)中部日本整形外科災害外科学会, May 2019, 中部日本整形外科災害外科学会雑誌, 62(3) (3), 599 - 600, Japanese
- (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 1 - 5, English四肢転移性骨腫瘍に対する外科的治療成績について
- (一社)日本皮膚悪性腫瘍学会, Apr. 2019, 日本皮膚悪性腫瘍学会学術大会プログラム・抄録集, 35回, 71 - 71, Japanese肉腫:診断から治療まで 軟部肉腫の診断と治療 整形外科骨軟部腫瘍専門医の経験と提言
- (一社)日本皮膚悪性腫瘍学会, Apr. 2019, 日本皮膚悪性腫瘍学会学術大会プログラム・抄録集, 35回, 71 - 71, Japanese肉腫:診断から治療まで 軟部肉腫の診断と治療 整形外科骨軟部腫瘍専門医の経験と提言
- (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(春季学会) (春季学会), 184 - 184, JapaneseAcromioclavicular joint cystに対し手術加療を行った3症例
- (一社)日本脊椎脊髄病学会, Mar. 2019, Journal of Spine Research, 10(3) (3), 269 - 269, Japanese転移性脊椎腫瘍に対する手術加療の費用対効用を低下させる因子の検討
- (一社)日本脊椎脊髄病学会, Mar. 2019, Journal of Spine Research, 10(3) (3), 269 - 269, Japanese転移性脊椎腫瘍に対する手術加療の費用対効用を低下させる因子の検討
- (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(春季学会) (春季学会), 266 - 266, Japanese四肢の腎癌骨転移に対して手術を施行した症例の検討
- (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(春季学会) (春季学会), 277 - 277, Japanese
- (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(3) (3), S806 - S806, Japanese四肢の腎癌骨転移に対して手術を施行した症例の検討
- 2019, 日本正常圧水頭症学会プログラム・抄録集, 20th特発性正常圧水頭症のバランス障害からみた歩行障害と転倒
- 2019, 日本正常圧水頭症学会プログラム・抄録集, 20th軽症の特発性正常圧水頭症における歩行障害に基づく機能評価の有用性
- 2019, 日本再生医療学会総会(Web), 18th, ROMBUNNO.P‐01‐050 (WEB ONLY), Japaneseリプログラミング因子を用いた人工骨肉腫幹細胞株の樹立
- THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, 2019, The Central Japan Journal of Orthopaedic Surgery & Traumatology, 62(3) (3), 599 - 600, Japanese20190905
- (公社)日本リハビリテーション医学会, Oct. 2018, The Japanese Journal of Rehabilitation Medicine, 55(秋季特別号) (秋季特別号), S274 - S274, Japanese70歳以上の脊椎転移患者の手術成績 PS、ADL、QOLの推移から
- (公社)日本リハビリテーション医学会, Oct. 2018, The Japanese Journal of Rehabilitation Medicine, 55(秋季特別号) (秋季特別号), S357 - S357, Japanese炭酸ガス経皮吸収による低酸素環境の改善が乳がん骨転移モデルの骨破壊を抑制する
- (公社)日本リハビリテーション医学会, Oct. 2018, The Japanese Journal of Rehabilitation Medicine, 55(秋季特別号) (秋季特別号), S367 - S367, Japanese脊椎転移の症候化リスク因子の前向き検討
- (一社)中部日本整形外科災害外科学会, 01 Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 121 - 121, Japanese
- (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8号) (8号), S1999 - S1999, Japanese[Refereed]
- (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8号) (8号), S1812 - S1812, Japanese[Refereed]
- (公社)日本整形外科学会, 05 Jun. 2018, 日本整形外科学会雑誌, 92(6) (6), S1535 - S1535, Japanese転移性骨腫瘍に対するホウ素中性子捕捉療法(BNCT)の検討
- (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6) (6), S1412 - S1412, Japanese
- (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6号) (6号), S1512 - S1512, Japanese[Refereed]
- (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6号) (6号), S1478 - S1478, Japanese[Refereed]
- (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6号) (6号), S1421 - S1421, Japanese[Refereed]
- (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6号) (6号), S1385 - S1385, Japanese[Refereed]
- (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6号) (6号), S1568 - S1568, Japanese[Refereed]Meeting report
- (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 1 - 8, Japaneseがん性疼痛に対する経皮的電気刺激治療(TENS)の効果の検討 a pilot study
- (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 3 - 10-7-2, Japanese当院における骨転移リハビリテーションの現状と症例の検討[Refereed]
- (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 1 - IP-10-6, Japanese新規低接着性コラーゲン(LASCol)はラット大腿骨骨欠損モデルにおいて骨癒合を促進する[Refereed]
- (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 1 - IP-12-5, Japanese経皮炭酸ガス吸収による低酸素環境の改善は乳癌骨転移モデルの骨破壊を抑制できる[Refereed]
- 07 Mar. 2018, 日本整形外科学会雑誌, 92(2) (2), S479, Japaneseホウ素中性子捕捉療法(BNCT)を用いた肉腫治療
- (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(3) (3), S971 - S971, Japanese
- (一社)日本脊椎脊髄病学会, Mar. 2018, Journal of Spine Research, 9(3号) (3号), 429 - 429, Japanese[Refereed]
- (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(3号) (3号), S1248 - S1248, Japanese[Refereed]
- (一社)中部日本整形外科災害外科学会, Mar. 2018, 中部日本整形外科災害外科学会雑誌, 61(春季学会) (春季学会), 162 - 162, Japanese小児の手指に発生したchondrolipomaの1例[Refereed]Meeting report
- (一社)日本骨折治療学会, 2018, 骨折, 40(Supplement) (Supplement), S40 - S40, Japanese大腿骨近位部病的骨折:人工関節の適応と限界
- Nov. 2017, PEDIATRIC BLOOD & CANCER, 64, S60 - S60, EnglishClinical Characteristics and Outcome of Pediatric Osteosarcoma: A Single-center Experience[Refereed]Summary international conference
- (公社)日本リハビリテーション医学会, Sep. 2017, The Japanese Journal of Rehabilitation Medicine, 54(秋季特別号) (秋季特別号), S230 - S230, Japanese特発性正常圧水頭症の動的平衡機能と歩行バランスとの関連
- (公社)日本リハビリテーション医学会, Sep. 2017, The Japanese Journal of Rehabilitation Medicine, 54(秋季特別号) (秋季特別号), S273 - S273, Japanese当院における骨転移リハビリテーションの現状とリハ介入因子の検討[Refereed]
- (一社)中部日本整形外科災害外科学会, Sep. 2017, 中部日本整形外科災害外科学会雑誌, 60(秋季学会) (秋季学会), 78 - 78, Japanese転移性骨腫瘍に対する腫瘍用人工関節の術後成績
- (一社)中部日本整形外科災害外科学会, Sep. 2017, 中部日本整形外科災害外科学会雑誌, 60(秋季学会) (秋季学会), 251 - 251, Japanese全身画像検索が診断に有用であった慢性再発性多発性骨髄炎(CRMO)の2例
- (株)全日本病院出版会, Sep. 2017, 整形外科最小侵襲手術ジャーナル, (84) (84), 79 - 83, Japanese転移性脊椎腫瘍に対する最小侵襲脊椎安定術(MISt)】 転移性脊椎腫瘍に対する出張型骨転移Cancer Boardの取り組み[Refereed]Introduction scientific journal
- Lippincott Williams and Wilkins, 01 Sep. 2017, Journal of Bone and Joint Surgery - American Volume, 99(18) (18), e101, English[Refereed]Report scientific journal
- (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1707 - S1707, Japanese
- (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1260 - S1260, Japanese
- (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1323 - S1323, Japanese
- (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1324 - S1324, Japanese
- (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1358 - S1358, Japanese
- (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1408 - S1408, Japanese
- (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1412 - S1412, Japanese
- (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1263 - S1263, Japanese平滑筋肉腫に対するホウ素中性子捕捉療法(BNCT)の適応についての検討
- (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1263 - S1263, Japanese悪性トライトン腫瘍に対するホウ素中性子捕捉療法(BNCT)の適応についての検討
- (公社)日本リハビリテーション医学会, May 2017, The Japanese Journal of Rehabilitation Medicine, 54(特別号) (特別号), 1 - 4, Japanese骨転移治療の現状 骨転移キャンサーボードとがんリハビリテーションが与える影響
- (公社)日本リハビリテーション医学会, May 2017, The Japanese Journal of Rehabilitation Medicine, 54(特別号) (特別号), 3 - 7, Japanese骨盤骨腫瘍に対して腫瘍切除後にHip transposition法を施行した2例
- (公社)日本リハビリテーション医学会, May 2017, The Japanese Journal of Rehabilitation Medicine, 54(特別号) (特別号), 1 - 2, JapaneseCombined Abduction TestおよびHorizontal Flexion Testと肩後方筋群の弾性率の関係
- (公社)日本リハビリテーション医学会, May 2017, The Japanese Journal of Rehabilitation Medicine, 54(特別号) (特別号), 1 - 3, Japanese野球選手における超音波検査を用いた筋弾性率と筋厚の評価
- (公社)日本理学療法士協会, Apr. 2017, 理学療法学, 44(Suppl.2) (Suppl.2), P - 3, Japanese特発性正常圧水頭症に対する体幹加速度計を用いた歩行分析 歩行変動に着目して
- (公社)日本理学療法士協会, Apr. 2017, 理学療法学, 44(Suppl.2) (Suppl.2), P - 4, Japanese中枢性麻痺後に生じる関節拘縮に対する経皮的炭酸ガス吸収療法の効果の検討
- (公社)日本理学療法士協会, Apr. 2017, 理学療法学, 44(Suppl.2) (Suppl.2), O - YB, Japaneseがん性疼痛に対する経皮的電気刺激治療(TENS)の効果の検討 a pilot study
- (一社)中部日本整形外科災害外科学会, Apr. 2017, 中部日本整形外科災害外科学会雑誌, 60(春季学会) (春季学会), 145 - 145, Japanese大腿骨に発生したFGF23産生腫瘍による腫瘍性骨軟化症の1例
- (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(2) (2), S260 - S260, Japanese
- (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(2) (2), S607 - S607, Japanese
- (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(3) (3), S1058 - S1058, Japanese
- (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(2) (2), S179 - S179, Japanese有症状脊椎転移の発生リスクに関する前向き研究
- 日本脊椎脊髄病学会, Feb. 2017, Journal of spine research : official journal of the Japanese Society for Spine Surgery and Related Research, 8(2) (2), 139 - 146, JapanesePrognosis in Surgical Management of Symptomatic Spinal Metastasis
- 公益社団法人 日本理学療法士協会, 2017, 理学療法学Supplement, 2016, 1072 - 1072, Japanese
【はじめに，目的】
特発性正常圧水頭症（iNPH）患者では小刻み，すり足，ワイドベースといった歩行障害に加えて，平衡障害に起因する姿勢バランス障害により転倒リスクが非常に高い。近年，転倒リスクの指標として歩行変動（歩行周期の時間や歩幅などの変動）が用いられるが，iNPH患者では歩行変動の異常が予想される。そこで，加速度計を用いて髄液タップテスト（TT）前後やシャント術後（術後）のiNPH患者の歩行変動を調査し健常高齢者との差異を検討した。
【方法】
対象はTT陽性でシャント術を受けたiNPH患者23例（男性19名，女性4名，年齢77.1±5.9歳）と健常高齢者18名（健常群：男性12名，女性6名，年齢74.3±3.4歳）である。体幹下部（L3中央）に3軸加速度計（MG-M1100）を装着し快適速度による10m歩行評価をTT前とTT3日後，術後1週時に実施した。そして，得られたstep time（1歩毎に要する時間）と重心移動量を反映する体幹下部の運動振幅（左右振幅，上下振幅），および両者の変動係数（coefficient of variation：CV）を解析した。統計解析にはiNPH群のTT前と健常群との比較にはt検定を，iNPH群のTT前後，シャント術後の比較には分散分析を用いた（有意水準5%）。
【結果】
TT前の歩行速度は健常群と比較してiNPH群で有意に減少していた（iNPH群0.72±0.33 m/s，健常群1.23±0.13 m/s）。step timeは健常群と比較してiNPH群で有意に延長し（iNPH群0.551±0.059 s，健常群0.505±0027 s），step time CVも有意に増大していた（iNPH群TT前10.70±7.79，健常群2.79±0.76）。体幹下部の左右運動振幅は健常群と比較してiNPH群で有意に増大し（iNPH群5.99±1.75 cm，健常群3.17±0.85 cm），上下運動振幅は有意に減少していた（iNPH群1.71±0.82 cm，健常群3.44±0.6 cm）。そして，運動振幅CVは左右，上下ともに健常群と比べてiNPH群で有意に増大していた（左右：iNPH群10.68±2.68，健常群8.82±1.97，上下：iNPH群25.6±14.95，健常群8.15±1.75）。TT後や術後の比較では，iNPH群の歩行速度は有意に改善した（TT後0.86±0.29 m/s，術後0.89±0.26m/s）。step time CVはTT後，術後ともに有意に改善し（TT後6.13±3.07，術後5.60±3.02），運動振幅CVも左右，上下とも改善した（左右：TT後8.62±3.0，術後8.87±3.03，上下：TT後17.86±8.82，術後15.84±7.27）。
【結論】
TT前のiNPH群の歩行では健常高齢者と比較して，歩行速度が低下しstep timeおよび重心移動も著しく変動していた。このことから，iNPH群では重心コントロールが稚拙なため，歩行が不安定となり歩行速度が低下し，転倒リスクが高まる可能性が示唆される。一方，TT後や術後は歩行速度が向上すると同時に歩行変動も軽減した。歩行速度の向上は歩行安定改善の結果と考えられるので，治療後のiNPH群の歩行安定性の改善を反映する歩行変動は，iNPH患者の歩行障害を評価する有用な指標であると考えられる。
- 公益社団法人 日本理学療法士協会, 2017, 理学療法学Supplement, 2016, 351 - 351, Japanese
【はじめに，目的】
中枢性麻痺後に生じる関節拘縮は，理学療法に難渋する合併症のひとつである。しかし，その治療法はポジショニング，関節可動域運動，物理療法といった古典的ともいえる方法から発展をみていない。経皮的に二酸化炭素を局所組織内に取り込むことで，局所的な血流増加や酸素分圧の上昇を含むBohr効果を促進する経皮的炭酸ガス吸収療法（CO2療法）が，骨折や筋萎縮などの改善に有効とする複数の報告が近年なされている。CO2療法の作用機序に，有酸素運動時に体内で生じる変化と共通するものがあることから，関節拘縮の新しい治療法になるという着想を得た。本研究では，私たちが確立している中枢性麻痺後の関節拘縮モデルであるラット脊髄損傷関節拘縮モデルの膝関節に対するCO2療法の効果を検討した。
【方法】
10週齢の雄性SDラットを対照群，脊髄損傷を行う群（SCI群），脊髄損傷後にCO2療法を行う群（CO2群）の3群に分け，2週間と4週間，介入した。SCI群およびCO2群は先行研究に従い，T8レベルで脊髄を完全に切断した。CO2療法介入はSCI術翌日から行った。下肢全体にハイドロゲルを塗布して100%のCO2ガスに暴露し，経皮的に吸収させた。介入は1日20分間，毎日行った。実験期間終了後，深麻酔下で膝関節伸展可動域（伸展ROM）を測定し，膝関節をまたぐ筋を全て切除し，再度伸展ROMを測定した。筋によるROM制限を筋性要因，関節構成体によるROM制限を関節性要因と定義し，それぞれは先行研究に従い算出した。また両下肢から半膜様筋を摘出し，筋湿重量を測定した後，急速凍結し，クリオスタットを用いて横断切片を作成し，HE染色を行った。光学顕微鏡を用いて画像を撮影し，image Jで筋線維横断面積（CSA）を計測した。さらに両下肢から膝関節を摘出し，川本法を用いて凍結包埋した。凍結サンプルから矢状切片を作成し，HE染色を施し，光学顕微鏡で画像を撮影，image Jで後方滑膜長を計測した。
【結果】
脊髄損傷により増大した伸展ROM制限は，2週，4週のCO2療法介入により改善した。2週では筋性要因，関節性要因，4週では関節性要因の改善が認められた。また，滑膜長は2週においては3群間に差は認められず，4週において対照群，CO2群と比較してSCI群で低値を示す傾向がみられた。半膜様筋の筋湿重量，CSAにはCO2療法介入による改善は認められなかった。
【結論】
本研究では，CO2療法のラット脊髄損傷関節拘縮モデルの伸展ROM制限に対する有効性が示された。介入により筋性要因と関節性要因の両方に改善がみられたが，特に4週の介入で関節構成体における改善傾向が認められた。CO2療法は簡便かつ非侵襲的であり，臨床でも施行しやすく，従来の治療法と組み合わせることで関節拘縮に対するより高い改善効果が期待される。
- 2017, 日本整形外科学会雑誌, 91(2) (2)Low-grade fibromyxoid sarcoma(Evans tumor)の診断における分子遺伝学的解析の有用性
- (一社)日本小児血液・がん学会, Nov. 2016, 日本小児血液・がん学会雑誌, 53(4) (4), 298 - 298, JapaneseG-CSF投与と自家末梢血幹細胞移植を併用しbi-weekly VDC-IE療法を完遂し得た切除不能ユーイング肉腫例
- Movement Disorder Society of Japan (MDSJ), Oct. 2016, パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 10回, 105 - 105, Japaneseパーキンソン病の前屈姿勢に対する入院リハビリテーション治療効果
- (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 153 - 153, Japanese当院における四肢転移性骨腫瘍に対する外科的治療の現状と治療成績
- (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 154 - 154, Japanese腸骨に発生したchronic expanding hematomaの1例
- (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1556 - S1556, Japanese
- (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1558 - S1558, Japanese
- (株)医学書院, Jul. 2016, 臨床整形外科, 51(7) (7), 601 - 605, Japanese脊椎腫瘍 最近の話題 転移性脊椎腫瘍の診断と治療戦略 骨転移Cancer Boardの活用[Invited]Introduction scientific journal
- (株)医学書院, Jul. 2016, 臨床整形外科, 51(7) (7), 644 - 646, Japanese最新基礎科学 知っておきたい 二酸化炭素の経皮吸収による悪性腫瘍の抗腫瘍効果[Invited]Introduction scientific journal
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1259 - S1259, Japanese
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1336 - S1336, Japanese
- (公社)日本リハビリテーション医学会, Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I206 - I206, Japanese脊椎転移に対する手術加療の費用対効用
- (公社)日本リハビリテーション医学会, Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I443 - I443, Japanese当院における骨転移キャンサーボード(Bone metastasis board:BMB)の取り組み 3年を経過して
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1181 - S1181, Japanese
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1254 - S1254, Japanese
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1261 - S1261, Japanese
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1265 - S1265, Japanese
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1286 - S1286, Japanese
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1293 - S1293, Japanese
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6号) (6号), S1245 - S1245, Japanese[Refereed]Meeting report
- (公社)日本リハビリテーション医学会, Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I253 - I253, Japaneseポリオ後遺症に対する経皮吸収炭酸ガス治療の有効性および安全性に関する探索的臨床研究[Refereed]
- (一社)日本脊椎脊髄病学会, Mar. 2016, Journal of Spine Research, 7(3) (3), 196 - 196, Japanese脊椎転移に対する集学的治療の予後改善効果
- (一社)中部日本整形外科災害外科学会, Mar. 2016, 中部日本整形外科災害外科学会雑誌, 59(春季学会) (春季学会), 278 - 278, Japanese乳幼児に股関節義足を作成し歩行を獲得した一例
- (公社)日本整形外科学会, Mar. 2016, 日本整形外科学会雑誌, 90(3) (3), S859 - S859, Japanese
- 2016, 日本正常圧水頭症学会プログラム・抄録集, 17th特発性正常圧水頭症の立位バランスの障害特性-重心動揺計を用いたパーキンソン病との比較-
- 2016, 日本小児血液・がん学会雑誌(Web), 53(4) (4)G-CSF投与と自家末梢血幹細胞移植を併用しbi-weekly VDC-IE療法を完遂し得た切除不能ユーイング肉腫例
- 2016, 臨床整形外科, 51, 109, Japanese新たな専門医制度に向かって[Invited]Others
- 2016, 整形外科, 67, 1030, Japanese医学系研究に関する倫理-ヘルシンキ宣言から学ぶこと-[Invited]Others
- 2016, 関節外科, 35, 122 - 130, Japanese【新専門医制度に備えた必履修分野の教え方・学び方】 必履修分野の研修方法 腫瘍[Invited]Introduction scientific journal
- Nov. 2015, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93(3) (3), E481 - E481, EnglishSpinal Instability Is Associated With Local Failure After Radiation Therapy in Patients With Spinal MetastasesSummary international conference
- (公社)日本整形外科学会, Sep. 2015, 日本整形外科学会雑誌, 89(8) (8), S1802 - S1802, JapaneseAICARの骨肉腫細胞に対するアポトーシス誘導効果
- (一社)中部日本整形外科災害外科学会, Sep. 2015, 中部日本整形外科災害外科学会雑誌, 58(秋季学会) (秋季学会), 282 - 282, Japanese後骨間神経麻痺を呈した前腕脂肪腫の一例Report scientific journal
- (公社)日本整形外科学会, Sep. 2015, 日本整形外科学会雑誌, 89(8) (8), S1803 - S1803, JapaneseMeeting report
- (公社)日本整形外科学会, Sep. 2015, 日本整形外科学会雑誌, 89(8) (8), S1674 - S1674, Japanese
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1241 - S1241, JapaneseAICARの骨肉腫細胞に対するアポトーシス誘導効果
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1229 - S1229, JapaneseMeeting report
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1227 - S1227, Japanese
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1238 - S1238, Japanese
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1308 - S1308, Japanese骨巨細胞腫の治療成績
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1383 - S1383, Japanese
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1293 - S1293, Japanese
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1320 - S1320, Japanese
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1355 - S1355, Japanese
- May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S254, Japanese様々な病態が重なり整復不能となった長腓骨筋腱脱臼の1例
- May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S208, Japanese筋損傷後の治癒過程におけるp21の役割
- May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S370, JapaneseTri-Lock Bone Preservation StemのDEXAによる術後骨密度変化の検討
- (公社)日本整形外科学会, Mar. 2015, 日本整形外科学会雑誌, 89(3) (3), S508 - S508, Japanese
- (一社)日本脊椎脊髄病学会, Mar. 2015, Journal of Spine Research, 6(3) (3), 486 - 486, Japanese
- (一社)日本脊椎脊髄病学会, Mar. 2015, Journal of Spine Research, 6(3) (3), 518 - 518, Japanese高齢者脊椎転移に対する手術成績
- (一社)日本脊椎脊髄病学会, Mar. 2015, Journal of Spine Research, 6(3) (3), 640 - 640, Japanese骨転移専門tumor boardの取り組み
- (公社)日本整形外科学会, Mar. 2015, 日本整形外科学会雑誌, 89(3) (3), S667 - S667, Japanese
- 克誠堂出版, 2015, 日本胸部臨床, 74(9) (9), 960 - 968, Japanese骨肉腫‐転移性肺腫瘍に対する外科的治療の役割と補助療法‐[Invited]Introduction scientific journal
- Oct. 2014, 日本足の外科学会雑誌, 35(2号) (2号), S212, Japanese足部に骨軟骨腫を生じた2例[Refereed]
- (一社)中部日本整形外科災害外科学会, Sep. 2014, 中部日本整形外科災害外科学会雑誌, 57(秋季学会) (秋季学会), 144 - 144, Japanese緊急的に股関節離断術を施行した乳児型線維肉腫の一例[Refereed]
- (公社)日本整形外科学会, Aug. 2014, 日本整形外科学会雑誌, 88(8号) (8号), S1685 - S1685, Japanese[Refereed]
- (公社)日本整形外科学会, Aug. 2014, 日本整形外科学会雑誌, 88(8号) (8号), S1683 - S1683, Japanese
- (公社)日本整形外科学会, Aug. 2014, 日本整形外科学会雑誌, 88(8号) (8号), S1682 - S1682, Japanese[Refereed]
- (公社)日本整形外科学会, Aug. 2014, 日本整形外科学会雑誌, 88(8号) (8号), S1552 - S1552, Japanese
- Jul. 2014, 日本中性子捕捉療法学会 第11回学術大会 一般演題54 (2014.07.05-06) 吹田, Japanese明細胞肉腫に対する新たな治療法としてのホウ素中性子捕捉療法：肺転移動物モデルに対するBNCT
- (公社)日本整形外科学会, Jun. 2014, 日本整形外科学会雑誌, 88(6) (6), S1127 - S1127, Japanese
- (公社)日本整形外科学会, Jun. 2014, 日本整形外科学会雑誌, 88(6) (6), S1181 - S1181, Japanese悪性末梢神経鞘腫瘍(MPNST)に対するホウ素中性子捕捉療法(BNCT)を用いた新たな治療方法
- (公社)日本整形外科学会, Jun. 2014, 日本整形外科学会雑誌, 88(6号) (6号), S1276 - S1276, Japanese
- May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S308, Japanese距骨に骨軟骨腫を生じた一例[Refereed]Meeting report
- May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S305, JapaneseG2ステム使用症例の短中期成績[Refereed]
- May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S308, Japanese有症性の両側第4腓骨筋腱に対する治療経験[Refereed]
- May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S491, Japanese大腿切断5年後に発症した断端神経腫の1例
- May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S261, Japanese炭酸ガス経皮投与は骨軟部肉腫においてiPS関連遺伝子の発現を低下させる
- May 2014, EUROPEAN SPINE JOURNAL, 23(Suppl 2) (Suppl 2), S267 - S270, English[Refereed]
- Apr. 2014, ORTHOPEDICS, 37(4) (4), E367 - +, English[Refereed]
- (公社)日本整形外科学会, 12 Mar. 2014, 日本整形外科学会雑誌, 88(3) (3), S645 - S645, Japanese徐放化抗癌剤抱合血管内皮前駆細胞を用いた新しい骨肉腫治療法の開発
- (一社)中部日本整形外科災害外科学会, Mar. 2014, 中部日本整形外科災害外科学会雑誌, 57(春季学会) (春季学会), 184 - 184, Japanese巨大骨嚢胞を伴う肘関節症に対して人工肘関節置換術を行った1例
- (公社)日本薬学会, Mar. 2014, 日本薬学会年会要旨集, 134年会(4) (4), 79 - 79, Japanese明細胞肉腫の肺転移動物モデルに対するホウ素中性子捕捉療法(BNCT)の検討
- (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(3) (3), S990 - S990, Japanese
- (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(2) (2), S372 - S372, Japaneseホウ素中性子捕捉療法(BNCT)を用いた転移性肺腫瘍に対する新たな治療方法の開発 明細胞肉腫の単発性肺転移モデルを用いた検討
- Mar. 2014, Journal of Spine Research, 5(3号) (3号), 570, Japanese高悪性度転移性脊椎腫瘍患者の手術例における全身状態、日常生活動作に関する前向き研究
- Mar. 2014, Journal of Spine Research, 5(3号) (3号), 487, Japanese転移性脊椎腫瘍患者の手術、非手術例における生命予後、歩行状態に関する前向き研究
- (一社)中部日本整形外科災害外科学会, Mar. 2014, 中部日本整形外科災害外科学会雑誌, 57(春季学会) (春季学会), 127 - 127, Japanese炭酸ガスと放射線併用療法による骨軟部肉腫に対する新しい治療法戦略の確立
- Mar. 2014, 日本整形外科学会雑誌, 88(3号) (3号), S930, Japanese転移性脊椎腫瘍への最新の知見 転移性脊椎腫瘍に対する手術成績 手術、非手術例の生命予後、全身状態、日常生活動作に関する前向き研究
- (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(3号) (3号), S643 - S643, Japanese
- (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(2号) (2号), S365 - S365, Japanese
- (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2013, 日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号55回・11回・18回, 55回・11回・18回, 275 - 275, Japanese初診時に血管腫と鑑別を要した右下腿原発乳児線維肉腫の新生児例
- Sep. 2013, 第10回日本中性子捕捉療法学会学術大会, Japanese明細胞肉腫に対する新たな治療法としてのホウ素中性子捕捉療法：肺転移動物モデルでの基礎的検討
- (公社)日本整形外科学会, Jun. 2013, 日本整形外科学会雑誌, 87(6) (6), S1217 - S1217, Japanese
- (公社)日本整形外科学会, Jun. 2013, 日本整形外科学会雑誌, 87(6) (6), S1238 - S1238, Japanese粘液線維肉腫へのホウ素中性子捕捉療法(BNCT)適用についての検討
- (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(2) (2), S107 - S107, Japanese整形外科領域におけるホウ素中性子捕捉療法(BNCT)
- THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, 2013, The Central Japan Journal of Orthopaedic Surgery & Traumatology, 56(2) (2), 367 - 368, JapanesePatella infera following endoprosthetic replacement for bone tumor of distal femur
- 金原出版(株), Oct. 2012, 整形・災害外科, 55(11) (11), 1286 - 1287, Japanese分子レベルからみた整形外科疾患(シリーズIX) MFH細胞株に対する血管新生阻害剤bevacizumabの効果Introduction scientific journal
- (一社)中部日本整形外科災害外科学会, Sep. 2012, 中部日本整形外科災害外科学会雑誌, 55(秋季学会) (秋季学会), 168 - 168, Japanese大腿骨遠位骨腫瘍に対する腫瘍用人工膝関節置換術後の膝蓋骨低位症の検討
- (公社)日本整形外科学会, 25 Jun. 2012, 日本整形外科学会雑誌, 86(6) (6), S941 - S941, Japaneseガドリニウム(Gd)中性子捕捉療法(Gd‐NCT)用Gd含有ナノ粒子の腫瘍内直接投与による腫瘍制御の可能性
- (公社)日本整形外科学会, Jun. 2012, 日本整形外科学会雑誌, 86(6) (6), S877 - S877, Japanese
- 2012, 日本小児整形外科学会雑誌, 21(3) (3)化膿性膝関節炎をきたした骨端部Brodie膿瘍の1例
- Nov. 2011, クリニシアン, 58巻, 11号, pp. 1235-1240, Japanese【運動器の10年-ロコモティブシンドロームと変形性膝関節症】 診断 変形性膝関節症の臨床症状と理学所見Introduction scientific journal
- Sep. 2011, EUROPEAN JOURNAL OF CANCER, 47, S666 - S666, EnglishAnti-apoptotic Effect of Decoy Receptor 3 in Human Malignant Fibrous Histiocytoma CellsSummary international conference
- Sep. 2011, EUROPEAN JOURNAL OF CANCER, 47, S665 - S665, EnglishMitochondrial Proliferation Induces Apoptosis in Human MFH Cells by PGC-1alpha OverexpressionSummary international conference
- 金原出版, Sep. 2011, 整形・災害外科, 54巻, 10号, pp. 1201-1205(10) (10), 1207 - 1211, Japanese【炎症など悪性骨・軟部腫瘍と見まちがう疾患-診断のポイント】 異所性骨化 その病態と軟部腫瘍、軟部骨肉腫、軟骨肉腫との鑑別点Introduction scientific journal
- May 2011, ANNALS OF ONCOLOGY, 22, 29 - 29, EnglishPKD1 inhibits invasion and migration ability of osteosarcoma cells via modulating MMP-2 and-9Summary international conference
- May 2011, ANNALS OF ONCOLOGY, 22, 25 - 25, EnglishSurvivin is a potent therapeutic target of MFH cell growthSummary international conference
- Oct. 2010, 整形外科, 61巻, 11号, pp. 1229-1230, JapaneseX線診断Q&A 骨線維性異形成(osteofibrous dysplasia)Introduction scientific journal
- Jun. 2010, EJC SUPPLEMENTS, 8(5) (5), 140 - 140, EnglishRole of protein kinase C delta in musculoskeletal tumoursSummary international conference
- Jun. 2010, EJC SUPPLEMENTS, 8(5) (5), 70 - 70, EnglishThe effect of bevacizumab on intratumoural angiogenesis of malignant fibrous histiocytoma in animal modelSummary international conference
- (公社)日本整形外科学会, Jun. 2010, 日本整形外科学会雑誌, 84(6) (6), S875 - S875, Japanese骨・軟部腫瘍におけるprotein kinase C-deltaの細胞増殖に関する役割についての検討
- (公社)日本整形外科学会, Aug. 2007, 日本整形外科学会雑誌, 81(8) (8), S966 - S966, Japanese
- (公社)日本整形外科学会, Jun. 2007, 日本整形外科学会雑誌, 81(6) (6), S801 - S801, Japanese
- (公社)日本整形外科学会, Jun. 2007, 日本整形外科学会雑誌, 81(6) (6), S801 - S801, Japanese
- (公社)日本整形外科学会, Jun. 2005, 日本整形外科学会雑誌, 79(6) (6), S703 - S703, JapaneseプロテインキナーゼインヒビターPKC412のヒト骨軟部悪性腫瘍細胞株に対する細胞増殖阻害作用の検討
- May 2005, 関節外科, 24巻, 5号, pp.640-646, Japanese【整形外科領域における3D-CTの有用性】 MDCTを用いた骨・軟部腫瘍診断[Refereed]Introduction scientific journal
- 2005, 日本整形外科学会雑誌, 79(6) (6)背部軟部腫ようの1例
- Oct. 2004, Orthopaedics, 17巻, 10号, pp. 50-54, Japanese【整形外科手術進入路 私の工夫】 上腕骨全置換術に対する進入路Introduction scientific journal
- Sep. 2004, ANTICANCER RESEARCH, 24(5D) (5D), 3533 - 3534, EnglishINHIBITORY EFFECT OF STI571 ON CELL PROLIFERATION OF HUMAN MALIGNANT FIBROUS HISTIOCYTOMA CELL LINESSummary international conference
- May 2004, Journal of Foot and Ankle Surgery, 43(3) (3), 185 - 190, English[Refereed]Book review
- Feb. 2004, 関節外科, 23巻, 2号, pp. 231-237, Japanese【高度骨欠損を伴う骨・関節疾患に対する骨補填材料】 骨腫瘍切除後の骨欠損に対するβ-TCPを用いた治療[Refereed]Introduction scientific journal
- 2004, Int Orthop, E059Multicentric giant cell tumor of the tendon sheath.[Refereed]
- 2004, Int Orthop, E057Metachronous, multicentric giant cell tumors in fibula and rib.[Refereed]
- 2004, Orthopedics, 27, 869-871Bilateral naviculocuneiform coalitions: Demonstration using multi-planar reconstruction CT imaging.[Refereed]
- Japanese Society of Radiological Technology, Oct. 2003, 日本放射線技術学会雑誌, 59巻, 10号, pp. 1201-1208(11) (11), 1361 - 1369, JapaneseIntroduction scientific journal
- (公社)日本整形外科学会, Jun. 2003, 日本整形外科学会雑誌, 77(6) (6), S756 - S756, Japanese高齢者に発症した軟部肉腫の治療成績
- (公社)日本整形外科学会, Jun. 2003, 日本整形外科学会雑誌, 77(6) (6), S776 - S776, Japanese
- (公社)日本整形外科学会, Jun. 2003, 日本整形外科学会雑誌, 77(6) (6), S884 - S884, Japanese
- Jun. 2003, SKELETAL RADIOLOGY, 32(6) (6), 367 - 370, English[Refereed]
- 文光堂, Jun. 2003, 臨床スポーツ医学, 20巻, 6号, pp. 649-653(6) (6), 649 - 653, Japanese【後十字靱帯損傷膝 病態と治療】 後十字靱帯損傷保存療法例の予後 MR像と膝不安定性との関連についてIntroduction scientific journal
- Jun. 2003, CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, Vol. 411, No. , pp. 236-244(411) (411), 236 - 244, EnglishIntroduction scientific journal
- Apr. 2003, Archives Of Pathology & Laboratory Medicine, Vol. 127, No. 4, pp. e186-e189, EnglishGranulocyte colony-stimulating factor-producing undifferentiated sarcoma occurring in previously fractured femur. A case report and review of the literatureIntroduction scientific journal
- 01 Mar. 2003, Journal of Rheumatology, 30(3) (3), 636 - 637, EnglishWhy "spondylodiscitis," why "SAPHO syndrome"? [1] (multiple letters)Report scientific journal
- Mar. 2003, JOURNAL OF RHEUMATOLOGY, 30(3) (3), 637 - 637, EnglishWhy "spondylodiscitis," why "SAPHO syndrome"? ReplyReport scientific journal
- (一社)中部日本整形外科災害外科学会, Mar. 2003, 中部日本整形外科災害外科学会雑誌, 46(春季学会) (春季学会), 149 - 149, Japanese妊婦に発生した脂肪肉腫の治療経験
- 2003, 日本整形外科学会雑誌, 77(6) (6)左肩軟部腫ようの1例
- 2003, 日本整形外科学会雑誌, 77(8) (8)悪性線維性組織球腫由来細胞株のチロシンキナーゼインヒビターST1571(メシル酸イマチニブ)に対する感受性の検討
- (一社)中部日本整形外科災害外科学会, Jan. 2003, 中部日本整形外科災害外科学会雑誌, 46(1) (1), 139 - 139, Japanese中指に弾発現象を呈した腱鞘線維腫の1例
- 南江堂, Aug. 2002, 整形外科 = Orthopedic surgery, 53(9) (9), 1183 - 1185, JapaneseIntraosseous lipoma of the femoral head ; a case report
- Aug. 2002, BRITISH JOURNAL OF DERMATOLOGY, 147(2) (2), 403 - 405, EnglishMulticentric localized giant cell tumour of the tendon sheath: two separate lesions at different sites in a fingerReport scientific journal
- 医学書院, Jul. 2002, 臨床整形外科, 37(7) (7), 871 - 873, JapaneseA Case of Tarsal Tunnel Syndrome caused by Epineural Ganglion
- 医学書院, Jun. 2001, 臨床整形外科, 36(6) (6), 799 - 801, JapaneseThe Clinical Outcome of Bilateral Clavicular Fracture : A Case Report
- 01 Mar. 1996, 中部日本整形外科災害外科学会雑誌, 39(2) (2), 467 - 468, JapaneseEvaluation of posterior instability and MR imaging in PCL deficient knees
- Contributor, 運動器疾患 がんの骨転移, 医学書院, Feb. 2025, Japanese, ISBN: 9784260054805今日の診断指針
- Contributor, V 治療後 2．転帰の記載方法, 金原出版, Apr. 2023, Japanese, ISBN: 9784307251679悪性軟部腫瘍取扱い規約 第4版
- Joint work, 南江堂, Feb. 2022原発性悪性骨腫瘍診療ガイドライン2022
- Joint work, Ⅱ．がんロコモ治療に必要ながん医療の基礎知識 １．がんの評価 ３）ステージ・TMN分類, 総合医学社, Oct. 2021チーム医療のための がんロコモハンドブック
- Joint work, 骨・軟部腫瘍および腫瘍類似疾患/悪性腫瘍の緩和ケア, 医学書院, Oct. 2021今日の整形外科治療指針
- Others, Medical View, Nov. 2012, Japanese膝関節の難治性病態に対する手術-日常診察で困った時のこの一冊 / 膝関節周囲に発生した骨巨細胞腫（GCT)に対する手術Scholarly book
- Joint work, 中山書店, 2006, Japanese最新整形外科学大系 17膝関節・大腿 / 3章 補助診断 シンチグラフィーScholarly book
- Joint work, 中山書店, 2006, Japanese最新整形外科学大系 / 骨軟部腫瘍および関連疾患、2章 骨腫瘍各論、軟骨粘液線維腫Textbook
- Joint work, 医療科学社, Oct. 2005, Japanese癌・治療効果判定の画像診断 / Ⅸ 骨・軟部B. 画像診断による治療効果判定Scholarly book
- The 71th 2025 Annual Meeting of Orthopaedic Research Society, Feb. 2025, EnglishRoles of SPRR1A in Tumorigenesis of Osteosarcoma: Insights from Newly Generated Artificial Cancer Stem CellsPoster presentation
- The 71th 2025 Annual Meeting of Orthopaedic Research Society, Feb. 2025, EnglishNext-generation sequencing approach to characterize slow-cycling cells in Ewing sarcomaPoster presentation
- 第49回日本足の外科学会学術集会, Nov. 2024, Japanese, (一社)日本足の外科学会人工足関節置換術後患者における足趾把持力と歩行能力の関係についてOral presentation
- 第38回日本整形外科学会基礎学術集会, Oct. 2024, Japanese, (公社)日本整形外科学会網羅的遺伝子解析を用いたEwing肉腫におけるslow-cycling-cellsの特性の探索Oral presentation
- 第38回日本整形外科学会基礎学術集会, Oct. 2024, Japanese, (公社)日本整形外科学会骨肉腫細胞におけるSPRR1Aの機能の探索 新規開発骨肉腫がん幹細胞様細胞を用いた検討Oral presentation
- 第143回中部日本整形外科災害外科学会, Oct. 2024, Japanese, (一社)中部日本整形外科災害外科学会がんロコモ対策の現状と課題 四肢骨転移に対する治療の現状と課題[Invited]Nominated symposium
- 第143回中部日本整形外科災害外科学会, Oct. 2024, Japanese, (一社)中部日本整形外科災害外科学会整形外科における女性医師キャリア形成の現状と課題 自身のキャリア形成の現状と課題 1度手術を手放した私が再び手術を学ぶチャンスをつかむまで[Invited]Nominated symposium
- 第143回中部日本整形外科災害外科学会, Oct. 2024, Japanese, (一社)中部日本整形外科災害外科学会膝関節内に巨大腫瘤を形成し腱滑膜巨細胞腫との鑑別を要した滑膜軟骨腫症の一例Oral presentation
- 第143回中部日本整形外科災害外科学会, Oct. 2024, Japanese, (一社)中部日本整形外科災害外科学会肘部管症候群を合併した右肘滑膜軟骨腫症の一例Oral presentation
- 第143回中部日本整形外科災害外科学会, Oct. 2024, Japanese, (一社)中部日本整形外科災害外科学会骨肉腫細胞におけるSPRR1Aの機能の探索 新規開発骨肉腫がん幹細胞様細胞を用いた検討Oral presentation
- 第143回中部日本整形外科災害外科学会, Oct. 2024, Japanese, (一社)中部日本整形外科災害外科学会Ewing肉腫におけるslow-cycling-cellsの特性の探索 次世代シーケンス解析を用いた検討Oral presentation
- 第57回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2024, Japanese, (公社)日本整形外科学会肉腫治療の次の一手 癌の骨浸潤に対してホウ素中性子捕捉療法(BNCT)は可能かOral presentation
- 第57回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2024, Japanese, (公社)日本整形外科学会Compress型インプラントによる腫瘍用人工関節置換術例の検討Oral presentation
- 第57回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2024, Japanese, (公社)日本整形外科学会Ewing肉腫におけるslow-cycling-cellsの特性の探索Oral presentation
- 第57回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2024, Japanese, (公社)日本整形外科学会骨肉腫細胞におけるSPRR1Aの機能の探索 新規開発骨肉腫がん幹細胞様細胞を用いた検討Oral presentation
- 第57回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2024, Japanese, (公社)日本整形外科学会転移性骨腫瘍に対するデノスマブ長期投与中止後の調査Nominated symposium
- 第57回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2024, Japanese, (公社)日本整形外科学会術前に陽子線を照射した粘液型脂肪肉腫の2例Poster presentation
- 第71回日本小児保健協会学術集会, Jun. 2024, Japanese, (公社)日本小児保健協会発達の気になる児童を対象とした地域で行う短期間のスポーツ実践が体力・運動機能に及ぼす影響Oral presentation
- 第97回日本整形外科学会学術総会, May 2024, Japanese, (公社)日本整形外科学会新しい骨転移診療ガイドラインにおける整形外科の関わりと意義 骨転移診断ガイドラインから見た骨転移に対する薬物療法Nominated symposium
- 第97回日本整形外科学会学術総会, May 2024, Japanese, (公社)日本整形外科学会脊椎転移手術における原発巣悪性度別手術成績比較Oral presentation
- 第142回中部日本整形外科災害外科学会, Apr. 2024, Japanese, (一社)中部日本整形外科災害外科学会小児脛骨に発症したBCG骨髄炎の1例Oral presentation
- 第142回中部日本整形外科災害外科学会, Apr. 2024, Japanese, (一社)中部日本整形外科災害外科学会30年の経過を経てchronic expanding hematomaを合併し増大した大腿部gossypiboma(ガーゼオーマ)の1例Oral presentation
- 第14回日本腎臓リハビリテーション学会学術集会, Mar. 2024, JapaneseAssociation between fatigue and step counts on dialysis and non-dialysis days in hemodialysis outpatientsOral presentation
- 第7回日本サルコーマ治療研究学会学術集会, Feb. 2024, Japanese粘液線維肉腫に対するホウ素中性子捕捉療法(BNCT)を用いた新たな治療法の可能性Oral presentation
- 第7回日本サルコーマ治療研究学会学術集会, Feb. 2024, Japanese骨肉腫細胞におけるSPRR1Aの機能の探索Oral presentation
- The 70th 2024 Annual Meeting of Orthopaedic Research Society, Feb. 2024, EnglishRoles of SPRR1A in tumorigenesis of osteosarcoma: a study using newly generated artificial cancer stem cellsPoster presentation
- 第7回日本リハビリテーション医学会秋季学術集会, Nov. 2023骨転移患者に対するリハビリテーション治療効果 傾向スコアマッチングを用いた検討Oral presentation
- 第38回日本整形外科学会基礎学術集会, Oct. 2023, Japanese, (公社)日本整形外科学会骨肉腫細胞におけるSPRR1Aの機能の探索Oral presentation
- 第６回日本がん・リンパ浮腫理学療法学会誌, Oct. 2023, Japanese, (一社)日本がん・リンパ浮腫理学療法学会Prehabilitationを実施した食道がん患者における症状、心理状態、健康関連QOLの変化Oral presentation
- 第141回中部日本整形外科災害外科学会, Oct. 2023, Japanese, (一社)中部日本整形外科災害外科学会左第2肋骨に生じた骨軟骨腫を胸腔鏡補助下に摘出した一例Oral presentation
- 神戸大学生命・自然科学 ELSI研究プロジェクト 発足記念イベント, Aug. 2023, JapaneseDBLR健康長寿研究拠点とELSI研究プロジェクト連携の展望[Invited]Nominated symposium
- 第56回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2023, Japanese, (公社)日本整形外科学会脊椎転移手術における悪性度別手術成績比較Oral presentation
- 第56回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2023, Japanese, (公社)日本整形外科学会小児中足骨発生の類上皮血管内皮腫の1例Poster presentation
- 第56回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2023, Japanese, (公社)日本整形外科学会高齢者の上肢に生じた切除不能な粘液線維肉腫に対するBNCTを用いた新たな治療法についての検討Oral presentation
- 第56回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2023, Japanese, (公社)日本整形外科学会骨肉腫細胞におけるSPRR1Aの機能の探索Poster presentation
- 第56回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2023, Japanese, (公社)日本整形外科学会化学療法と炭素イオン線治療により5年生存し,歩行機能を温存しえた71歳の寛骨臼骨肉腫の1例Poster presentation
- 第56回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2023, Japanese, (公社)日本整形外科学会本邦における骨盤発生悪性骨・軟部腫瘍に対する手術と粒子線の治療成績の比較Poster presentation
- 第60回日本リハビリテーション医学会学術集会, Jun. 2023, Japanese, (公社)日本リハビリテーション医学会骨転移キャンサーボードが骨転移患者のQOLに及ぼす影響に関する検討Oral presentation
- 第60回日本リハビリテーション医学会学術集会, Jun. 2023, Japanese, (公社)日本リハビリテーション医学会急性期脳梗塞患者のサルコペニアが1年後の機能アウトカムに及ぼす影響 前向きコホート研究Oral presentation
- 第96回日本整形外科学会学術総会, May 2023, Japanese, (公社)日本整形外科学会本邦における骨盤発生悪性骨・軟部腫瘍の臨床成績と予後因子の検討Poster presentation
- 第96回日本整形外科学会学術総会, May 2023, Japanese, (公社)日本整形外科学会脊椎転移術後創離開のリスク因子の検討と予防のための新たな試み Curved skin incisionOral presentation
- 第140回中部日本整形外科災害外科学会, Apr. 2023, Japanese, (一社)中部日本整形外科災害外科学会足趾に生じた粘液型脂肪肉腫の一例Oral presentation
- 第13回日本腎臓リハビリテーション学術集会, Mar. 2023, Japanese外来血液透析患者における疲労感と非透析日の歩数の関連Oral presentation
- 神戸大学 デジタルバイオ&ライフサイエンスリサーチパーク(DBLR)開設記念シンポジウム, Mar. 2023, JapaneseDBLR及び各拠点の紹介 -健康長寿研究拠点-[Invited]Nominated symposium
- 第6回日本サルコーマ治療研究学会学術集会, Feb. 2023, Japanese肉腫に対するホウ素中性子捕捉療法（BNCT)適応の可能性と課題[Invited]Nominated symposium
- 第6回日本サルコーマ治療研究学会学術集会, Feb. 2023, Japanese本邦における骨盤発生悪性骨軟部腫瘍の臨床成績の検討Poster presentation
- 第6回日本サルコーマ治療研究学会学術集会, Feb. 2023, JapaneseEwing肉腫におけるslow-cycling cellsの同定Poster presentation
- The 69th 2023 Annual Meeting of Orthopaedic Research Society, Feb. 2023, EnglishRoles of SPRR1A in osteosarcoma cellsPoster presentation
- The 69th 2023 Annual Meeting of Orthopaedic Research Society, Feb. 2023, EnglishIdentification of Slow-Cycling Cells in Ewing sarcoma.
- 第50回四国理学療法士学会, Nov. 2022, Japanese食道癌切除術を受けた胸部食道癌患者の術後身体活動量が肺炎発症に及ぼす影響
- ZimmerBiomet リバースショルダー講習会, Nov. 2022, JapaneseReverse Shoulder Guidline Lecture for Tumor. Surgical indications for extensive resection of bone and soft tissue tumor[Invited]Public discourse
- 第6回日本リハビリテーション医学会秋季学術集会, Nov. 2022, Japanese, (公社)日本リハビリテーション医学会特発性正常圧水頭症における髄液シャント 術後の歩行・バランス評価の臨床的意義の ある最小変化量Oral presentation
- 2022 TMU and APAMI Joint International Conference, Nov. 2022, EnglishPrecision Medicine and Care in Kobe University[Invited]Invited oral presentation
- 第139回中部日本整形外科災害外科学会, Oct. 2022, Japanese内軟骨腫との鑑別を要した小児中足骨発生の類上皮血管内皮腫の1例
- 第139回中部日本整形外科災害外科学会・学術集会, Oct. 2022, Japanese軟骨肉腫との鑑別を要した骨盤軟骨粘液線維腫の一例Oral presentation
- 第37回日本整形外科学会基礎学術集会, Oct. 2022, Japanese, (公社)日本整形外科学会骨肉腫細胞におけるsprr1aの機能の探索Oral presentation
- 第37回日本整形外科学会基礎学術集会, Oct. 2022, (公社)日本整形外科学会Ewing肉腫におけるslow-cycling cellsの同定Oral presentation
- 第81回日本公衆衛生学会総会, Oct. 2022, Japanese高齢者肺炎球菌ワクチン接種が要介護認定に及ぼす影響：LIFE study
- 第81回日本公衆衛生学会総会, Oct. 2022, Japanese高齢者肺炎球菌ワクチンの接種率および接種関連要因の検討: LIFE StudyOral presentation
- 第81回日本公衆衛生学会総会, Oct. 2022, Japanese児童期後期のcentralityが一年間の身体活動量に与える影響Oral presentation
- 第55回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2022, Japanese, (公社)日本整形外科学会明細胞肉腫薬物治療におけるLAT1阻害剤による増感効果の検討Oral presentation
- 第55回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2022, Japanese, (公社)日本整形外科学会Ewing肉腫におけるslow-cycling cellの同定Oral presentation
- 第55回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2022, Japanese, (公社)日本整形外科学会腹腔外デスモイド型線維腫症に対するWait & Seeの治療成績Oral presentation
- 第55回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2022, Japanese, (公社)日本整形外科学会悪性末梢神経鞘腫瘍の治療成績Oral presentation
- 第55回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2022, Japanese, (公社)日本整形外科学会手足に生じた軟部肉腫の治療成績と予後因子に関する検討Oral presentation
- 第55回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2022, Japanese, (公社)日本整形外科学会骨盤発生悪性骨・軟部腫瘍の治療成績と予後因子の検討Oral presentation
- 第55回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2022, Japanese, (公社)日本整形外科学会骨肉腫肺転移症例の検討Oral presentation
- 第55回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2022, Japanese, (公社)日本整形外科学会類上皮肉腫に対するホウ素中性子捕捉療法(BNCT)を用いた新たな治療方法の開発Oral presentation
- 第34回大阪府理学療法学術大会学会, Jul. 2022, Japanese, (公社)大阪府理学療法士会前十字靱帯再損傷と恐怖心の関連【卒業研究】Oral presentation
- 第59回日本リハビリテーション医学会学術集会, Jun. 2022, Japanese, (公社)日本リハビリテーション医学会両大腿骨切迫骨折に対し、両側髄内定固定術を施行された一症例Oral presentation
- 第59回日本リハビリテーション医学会学術集会, Jun. 2022, Japanese, (公社)日本リハビリテーション医学会キャンサーボードを用いた骨転移患者診療の経時的変化Oral presentation
- 第95回日本整形外科学会学術総会, May 2022, Japanese, (公社)日本整形外科学会Ewing肉腫におけるslow-cycling cellの同定Oral presentation
- 第95回日本整形外科学会学術総会, May 2022, Japanese, (公社)日本整形外科学会肉腫に対する加速器を用いたホウ素中性子捕捉療法(BNCT)の可能性Oral presentation
- 第138回中部日本整形外科災害外科学会・学術集会, Apr. 2022, Japanese, (一社)中部日本整形外科災害外科学会手足に生じた軟部肉腫の予後に関する検討Oral presentation
- The 68th 2022 Annual Meeting of Orthopaedic Research Society, Feb. 2022, EnglishIdentification of Slow-cycling Cell in Ewing SarcomaOral presentation
- The 68th 2022 Annual Meeting of Orthopaedic Research Society, Feb. 2022, EnglishThe Regulatory Roles of MiRNAs 16, 133a, And 223 on Osteoclastic Bone Destruction by Breast Cancer MetastasisOral presentation
- 第36回日本整形外科学会基礎学術集会, Oct. 2021乳癌骨転移による骨破壊に寄与するmiRNAの検討Oral presentation
- 第36回日本整形外科学会基礎学術集会, Oct. 2021Ewing肉腫におけるslow-cycling cellsの同定Oral presentation
- 第137回中部日本整形外科災害外科学会学術集会, Oct. 2021慢性再発性多発性骨髄炎の一例Oral presentation
- 第54回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2021, Japanese, (公社)日本整形外科学会未分化多形肉腫の治療成績
- 第54回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2021, Japanese, (公社)日本整形外科学会乳癌骨転移における骨破壊に寄与するmiRNAの探索
- 第54回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2021, Japanese, (公社)日本整形外科学会軟部肉腫における無計画切除例の治療成績と予後因子の検討
- 第54回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2021, Japanese, (公社)日本整形外科学会高齢者に発症した骨巨細胞腫についての調査結果
- 第54回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2021, Japanese, (公社)日本整形外科学会Ewing肉腫におけるslow-cycling cellsの同定
- 第54回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2021, Japanese, (公社)日本整形外科学会滑膜肉腫に対するL型アミノ酸トランスポータ1(LAT1)の発現およびホウ素中性子捕捉療法(BNCT)適応の検討
- 第54回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2021, Japanese, (公社)日本整形外科学会骨盤悪性骨腫瘍に対する粒子線治療の長期成績
- 第60回日本生体医工学会大会・第36回日本生体磁気学会大会, Jun. 2021, Japanese物理療法によるメカニカルストレスを活用した新たな骨折・骨粗鬆症治療法の開発Oral presentation
- Virtual ISPRM 2021 Congress, Jun. 2021, EnglishTranscutaneous carbon dioxide improves inflammation in rat osteoarthritisOral presentation
- Virtual ISPRM 2021 Congress, Jun. 2021, EnglishEffects of treadmill running exercise with different intensities on trabecular bone in growing miceOral presentation
- Virtual ISPRM 2021 Congress, Jun. 2021, EnglishEnvironmental enrichment improves motor coordination and increases brain weight in healthy young miceOral presentation
- 第94回日本整形外科学会学術総会, May 2021, Japanese, (公社)日本整形外科学会軟部肉腫肺転移患者における肺転移の治療アプローチの予後への影響
- World Physiotherapy Congress 2021, Apr. 2021, EnglishLateral postural sway during gait in moderate-stage Parkinson’s disease: does it matter for postural control?Oral presentation
- 第136回中部日本整形外科災害外科学会・学術集会, Apr. 2021, Japanese肩関節周囲に生じた巨大な結節性偽痛風の1例Oral presentation
- The 67th 2021 Annual Meeting of Orthopaedic Research Society, Feb. 2021, EnglishIdentification of Dormant Cells in Ewing SarcomaPoster presentation
- The 67th 2021 Annual Meeting of Orthopaedic Research Society, Feb. 2021, EnglishIdentification of Associated MicroRNAs in Bone Destruction by Breast Cancer MetastasisPoster presentation
- 第25回日本基礎理学療法学会学術大会, Dec. 2020炭酸ガスペースト(ディレコート®)による人工Bohr 効果の検証Oral presentation
- 第25回日本基礎理学療法学会学術大会, Dec. 2020, Japaneseラット変形性膝関節症に対する経皮的炭酸ガス療法の効果Oral presentation
- 第4回日本リハビリテーション医学会秋季学術集会, Nov. 2020がんロコモと骨転移Nominated symposium
- 第4回日本リハビリテーション医学会秋季学術集会, Nov. 2020骨転移キャンサーボードを用いたリハビリテーション治療における患者QOLに影響を与える因子の検討Oral presentation
- 第35回日本整形外科学会基礎学術集会, Oct. 2020遺伝子導入による人工骨肉腫幹細胞株の樹立Oral presentation
- 第35回日本整形外科学会基礎学術集会, Oct. 2020乳癌骨転移における骨破壊に寄与するmiRNAの探索Oral presentation
- 第35回日本整形外科学会基礎学術集会, Oct. 2020Ewing肉腫におけるcellular dormancyの同定とその特性の探索Oral presentation
- 第135回中部日本整形外科災害外科学会・学術集会, Oct. 2020寛骨臼の転移性骨腫瘍に対して骨セメント充填及びスクリューによる内固定を行った2例Oral presentation
- 第53回日本整形外科学会骨・軟部腫瘍学術集会, Sep. 2020骨・軟部肉腫による脳転移例の検討Poster presentation
- 第53回日本整形外科学会骨・軟部腫瘍学術集会, Sep. 2020がん骨転移における骨破壊に寄与するmiRNAの探索Poster presentation
- 第53回日本整形外科学会骨・軟部腫瘍学術集会, Sep. 2020骨肉腫細胞における特定因子導入を用いたがん幹細胞特性の獲得Oral presentation
- 第53回日本整形外科学会骨・軟部腫瘍学術集会, Sep. 2020滑膜肉腫の治療成績Oral presentation
- 第93回日本整形外科学会学術総会, Jun. 2020炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる 臨床試験の報告Oral presentation
- 第93回日本整形外科学会学術総会, Jun. 2020悪性軟部腫瘍肺転移に対する肺転移切除の意義Poster presentation
- 第49回日本インターベンショナルラジオロジー学会総会, Aug. 2020骨転移疼痛に対する集学的治療 -この痛みをどう治療するか- 転移性骨腫瘍に対する外科的治療Nominated symposium
- 第57回日本リハビリテーション医学会学術集会, Aug. 2020頚椎転移患者の手術成績と成績不良因子の検討 ーPS，QOLの推移からーOral presentation
- 第134回中部日本整形外科災害外科学会・学術集会, Apr. 2020前腕に発生した悪性グロームス腫瘍の1例Oral presentation
- The 66th Annual Meeting of Orthopaedic Research Society, Feb. 2020A New Method To Generate Osteosarcoma Cells With Cancer Stem Cell Properties By Reprogramming FactorsPoster presentation
- The 66th Annual Meeting of Orthopaedic Research Society, Feb. 2020Identification Of Associated MicroRNAs In Bone Destruction Of Breast Cancer MetastasisPoster presentation
- The 66th Annual Meeting of Orthopaedic Research Society, Feb. 2020Development Of Novel Therapeutic Strategy For Osteosarcoma Transplanting Controlled-release Pirarubicin Conjugated Endothelial Progenitor CellsPoster presentation
- 第24回日本基礎理学療法学会学術大会, Nov. 2019経皮的炭酸ガス吸収療法がヒト骨格筋および関節可動域に及ぼす影響Oral presentation
- 第34回日本整形外科学会基礎学術集会, Oct. 2019リプログラミング因子を用いた人工骨肉腫幹細胞株の樹立とその特性の探索Poster presentation
- 第34回日本整形外科学会基礎学術集会, Oct. 2019がん骨転移における骨破壊に寄与するmiRNAの同定Poster presentation
- 第133回中部日本整形外科災害外科学会, Sep. 2019発熱性好中球減少症と鑑別を要したG-CSF投与による大動脈炎の1例Oral presentation
- 第31回日本運動器科学会, Jul. 2019大腿骨近位部病的骨折 人工関節の適応と限界Oral presentation
- 第52回日本整形外科骨・軟部腫瘍学術集会, Jul. 2019右足部軟部腫瘍の1例Oral presentation
- 第52回日本整形外科骨・軟部腫瘍学術集会, Jul. 2019骨巨細胞腫に対する治療成績Oral presentation
- 第52回日本整形外科骨・軟部腫瘍学術集会, Jul. 2019手指，足趾発生の腱鞘巨細胞腫に対する治療成績Oral presentation
- 第52回日本整形外科骨・軟部腫瘍学術集会, Jul. 2019Wait & see policyで初回治療を行った腹腔外デスモイド型線維腫症の検討Oral presentation
- 第52回日本整形外科骨・軟部腫瘍学術集会, Jul. 2019リプログラミング因子を用いた人工骨肉腫幹細胞株の樹立Poster presentation
- 第52回日本整形外科骨・軟部腫瘍学術集会, Jul. 2019明細胞肉腫に対するLAT1阻害剤の抗腫瘍効果の検討Poster presentation
- 第52回日本整形外科骨・軟部腫瘍学術集会, Jul. 2019骨肉腫に対する徐放化抗癌剤抱合血管内皮前駆細胞を用いた新規がん治療法の開発Oral presentation
- 第52回日本整形外科骨・軟部腫瘍学術集会, Jul. 2019粘液型脂肪肉腫の治療成績Poster presentation
- 第52回日本整形外科骨・軟部腫瘍学術集会, Jul. 2019坐骨神経近傍に発生した悪性筋上皮腫の1例Poster presentation
- 第52回日本整形外科骨・軟部腫瘍学術集会, Jul. 2019骨・軟部肉腫における脳転移症例の検討Poster presentation
- 13th International Society of Physical and Rehabilitation Medicine World Congress (ISPRM 2019), Jun. 2019, EnglishWhich Clinical Assessments are Useful for Differentiating Fallers from Non-Faller in Idiopathic Normal Pressure Hydrocephalus?Poster presentation
- 13th International Society of Physical and Rehabilitation Medicine World Congress (ISPRM 2019), Jun. 2019, EnglishTranscutaneous Carbon Dioxide Improves Contractures after Spinal Cord Injury in Rats.Poster presentation
- 第24回日本緩和医療学会学術大会, Jun. 2019がん性疼痛に対する経皮的電気刺激治療(TENS)の効果の検討Oral presentation
- 第56回日本リハビリテーション医学会学術集会, Jun. 2019四肢転移性骨腫瘍に対する外科的治療成績についてOral presentation
- 第56回日本リハビリテーション医学会学術集会, Jun. 2019がんの骨転移症例に対するリハビリテーション医療の現状と症例検討Oral presentation
- 第56回日本リハビリテーション医学会学術集会, Jun. 2019ラット腱板修復術モデルに対するbFGFおよびPRP同時投与の有効性の検討Oral presentation
- 第20回埼玉整形外科研究会, Jun. 2019骨転移診療における整形外科医の役割－がん難民をなくすために－[Invited]Invited oral presentation
- World Confederation for Physical Therapy (WCPT) Congress 2019, May 2019, EnglishCarbon dioxide therapy improves contractures following joint immobilization.Poster presentation
- World Confederation for Physical Therapy (WCPT) Congress 2019, May 2019, EnglishEffects of carbon dioxide therapy on the alternations in muscles and joint components following joint immobilization.Poster presentation
- World Confederation for Physical Therapy (WCPT) Congress 2019, May 2019, EnglishEffects of transcutaneous carbon dioxide therapy on alterations in muscles and joint components after spinal cord injury in rats.Poster presentation
- World Confederation for Physical Therapy (WCPT) Congress 2019, May 2019, EnglishEffects of botulinum toxin therapy on muscles and joint components responsible for contractures after spinal cord injuries.Poster presentation
- World Confederation for Physical Therapy (WCPT) Congress 2019, May 2019, EnglishSpasticity is not the sole trigger rather is only the partial contributor of contractures after spinal cord injuries.Poster presentation
- 第92回日本整形外科学術総会, May 2019四肢の腎癌骨転移に対して手術を施行した症例の検討Oral presentation
- 第35回日本皮膚悪性腫瘍学会学術大会, May 2019軟部肉腫の診断と治療－整形外科骨軟部腫瘍専門医の経験と提言－[Invited]Nominated symposium
- 第132回中部日本整形外科災害外科学会, Apr. 2019Acromioclavicular joint cystに対し手術加療を行った3症例Oral presentation
- 第132回中部日本整形外科災害外科学会, Apr. 2019四肢の腎癌骨転移に対して手術を施行した症例の検討Oral presentation
- 第132回中部日本整形外科災害外科学会, Apr. 2019仙腸関節部に発生したホスホグリセリド結晶沈着症の1例Oral presentation
- 第48回日本脊椎精髄病学会学術集会, Apr. 2019転移性脊椎腫瘍に対する手術加療の費用対効用を低下させる因子の検討Oral presentation
- 第18回日本再生医療学会総会, Mar. 2019, Japanese, 神戸, Domestic conferenceリプログラミング因子を用いた人工骨肉腫幹細胞株の樹立Poster presentation
- 第452回整形外科集談会京阪神地方会, Feb. 2019, Japanese, 中部日本整形外科災害外科学会, 大阪, Domestic conference膝関節軟骨穿破を伴ったBrodie膿瘍を長期経過観察した一例Oral presentation
- 第20回日本正常圧水頭症学会, Feb. 2019, Japanese, 日本正常圧水頭症学会, 大阪, Domestic conference特発性正常圧水頭症のバランス障害からみた歩行障害と転倒Oral presentation
- 第152回関西骨軟部腫瘍研究会, Feb. 2019, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference小児脛骨病変の1例Oral presentation
- 第20回日本正常圧水頭症学会, Feb. 2019, Japanese, 日本正常圧水頭症学会, 大阪, Domestic conference軽症の特発性正常圧水頭症における歩行障害に基づく機能評価の有用性Oral presentation
- 第2回日本サルコーマ治療研究学会学術集会, Feb. 2019, Japanese, 日本サルコーマ治療研究学会, 東京, Domestic conferenceリプログラミング因子を用いた人工骨肉腫幹細胞株の樹立Poster presentation
- The 65th Annual Meeting of Orthopaedic Research Society, Feb. 2019, English, Orthopaedic Research Society, Austin, International conferenceTranscutaneous CO2 application Accelerates Bone Healing in a Rat Femoral Defect ModelPoster presentation
- The 65th Annual Meeting of Orthopaedic Research Society, Feb. 2019, English, Orthopaedic Research Society, Austin, Domestic conferenceDevelopment of New Hybrid Treatment forOsteosarcoma Transplanting Controlled-Release Pirarubicin Conjugated Endothelial Progenitor CellPoster presentation
- The 65th Annual Meeting of Orthopaedic Research Society, Feb. 2019, English, Orthopaedic Research Society, Austin, Domestic conferenceDevelopment of Induced Osteosarcoma Stem Cells Using Induced Pluripotent Stem (iPs) Cells Production TechnologyPoster presentation
- The 65th Annual Meeting of Orthopaedic Research Society, Feb. 2019, English, Orthopaedic Research Society, Austin, Domestic conferenceA Newly Developed Low Adhesive Scaffold Collagen (LASCol) Accelerates Bone Healing in a Rat Femur Osteotomy ModelPoster presentation
- 熊本県臨床整形外科医会教育研修講演会, Jan. 2019, Japanese, 熊本県臨床整形外科医会, 熊本, Domestic conference骨腫瘍および腫瘍類似疾患の診療 -外来診療でのポイントとpitfall-[Invited]Invited oral presentation
- 第151回関西骨軟部腫瘍研究会, Dec. 2018, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference大腿軟部腫瘍の1例Oral presentation
- 第2回日本リハビリテーション医学会秋季学術集会, Nov. 2018, Japanese, 日本リハビリテーション医学会, 仙台, Domestic conference脊椎転移の症候化リスク因子の前向き検討Oral presentation
- 平成30年度 第2回 AMED佐々木班小児腫瘍分科会, Nov. 2018, Japanese, スペーサ治療研究会, 京都, Domestic conference骨軟部部門の経過報告と今後の展望 -吸収性スペーサーの適応拡大と実用化研究-[Invited]Invited oral presentation
- The 16th Biennial Conference of the International Society for Fracture Repair, Nov. 2018, English, Orthopaedic Research Society, 京都, International conferenceTopical cutaneous application of carbon dioxide using ahydrogel is anovel treatment option to assist fracture repair -Results of a clinical trial-Poster presentation
- 2018 CTOS Annual Meeting, Nov. 2018, English, The Connective Tissue Oncology Society, Rome, International conferenceBenefit of surgical treatment for pulmonary metastasis in soft tissue sarcoma patients.Poster presentation
- 第2回日本リハビリテーション医学会秋季学術集会, Nov. 2018, Japanese, 日本リハビリテーション医学会, 仙台, Domestic conference70歳以上の脊椎転移患者の手術成績 -PS、ADL、QOLの推移から-Oral presentation
- 第9回兵庫県転移性骨腫瘍治療研究会, Oct. 2018, Japanese, 兵庫県転移性骨腫瘍治療研究会, 神戸, Domestic conference整形外科の介入が遅れた転移性骨腫瘍の2症例Oral presentation
- 第33回日本整形外科学会基礎学術集会, Oct. 2018, Japanese, 日本整形外科学会, 奈良, Domestic conference新規低接着性scaffold collagen(LASCol)はラット骨欠損モデルにおいて骨癒合を促進するPoster presentation
- 第11回スペーサー治療研究会, Oct. 2018, Japanese, スペーサ治療研究会, 横浜, Domestic conference骨軟部部門の経過報告と今後の展望 -吸収性スペーサーの適応拡大と実用化研究-[Invited]Invited oral presentation
- 第131回中部日本整形外科災害外科学会, Oct. 2018, Japanese, 中部日本整形外科災害外科学会, 倉敷, Domestic conference後頸部に発症した良性対称性脂肪腫症の一例Oral presentation
- 第131回中部日本整形外科災害外科学会・学術集会, Oct. 2018, Japanese, 中部日本整形外科災害外科学会, 倉敷, Domestic conference後頚部に発症した良性対称性脂肪腫症の一例Oral presentation
- The 34th Annual Meeting of the Orthopaedic Trauma Association, Oct. 2018, English, Orthopaedic Trauma Association, Orlando, International conferenceTopical cutaneous application of carbon dioxide using a hydrogel is a new treatment option to assist fracture repair: results of a clinical trialPoster presentation
- 第33回日本整形外科学会基礎学術集会, Oct. 2018, Japanese, 日本整形外科学会, 奈良, Domestic conferenceiPS作製技術を用いた人工骨肉腫幹細胞株の樹立Poster presentation
- 第15回日本中性子捕捉療法学会学術大会, Sep. 2018, Japanese, 日本中性子捕捉療法学会, 札幌, Domestic conference肺癌骨転移に対するホウ素中性子捕捉療法(BNCT)の可能性についてOral presentation
- 第51回日本整形外科骨・軟部腫瘍学術集会, Jul. 2018, Japanese, 日本整形外科学会, 静岡, Domestic conference不安定性を有する転移性脊椎腫瘍に対する治療 脊椎転移に対する手術療法の効果Public symposium
- 第51回日本整形外科骨・軟部腫瘍学術集会, Jul. 2018, Japanese, 日本整形外科学会, 静岡, Domestic conference粘液線維肉腫の治療成績Poster presentation
- 第51回日本整形外科骨・軟部腫瘍学術集会, Jul. 2018, Japanese, 日本整形外科学会, 静岡, Domestic conference転移性骨腫瘍に対するホウ素中性子捕捉療法(BNCT)の検討Oral presentation
- 第44回日本骨折治療学会, Jul. 2018, Japanese, 日本骨折治療学会, 岡山, Domestic conference大腿骨近位部病的骨折の治療戦略 大腿骨近位部病的骨折 人工関節の適応と限界Nominated symposium
- 第51回日本整形外科骨・軟部腫瘍学術集会, Jul. 2018, Japanese, 日本整形外科学会, 静岡, Domestic conference脊椎転移に対する手術療法の効果Oral presentation
- 第51回日本整形外科骨・軟部腫瘍学術集会, Jul. 2018, Japanese, 日本整形外科学会, 静岡, Domestic conference初発転移が膵であった腓骨原発骨肉腫の1例Poster presentation
- 第51回日本整形外科骨・軟部腫瘍学術集会, Jul. 2018, Japanese, 日本整形外科学会, 静岡, Domestic conference四肢の腎癌骨転移に対して手術を施行した症例の検討Oral presentation
- 第51回日本整形外科骨・軟部腫瘍学術集会, Jul. 2018, Japanese, 日本整形外科学会, 静岡, Domestic conference経皮炭酸ガス吸収による低酸素環境の改善は乳癌骨転移モデルの骨破壊を抑制するPoster presentation
- 第51回日本整形外科骨・軟部腫瘍学術集会, Jul. 2018, Japanese, 日本整形外科学会, 静岡, Domestic conferenceLow-grade fibromyxoid sarcoma(Evans tumor)の臨床病理学的検討 診断におけるFISHの有用性Oral presentation
- 第55回日本リハビリテーション医学会学術集会, Jun. 2018, Japanese, 日本リハビリテーション医学会, 福岡, Domestic conference当院における骨転移リハビリテーションの現状と症例の検討Oral presentation
- 第55回日本リハビリテーション医学会学術集会, Jun. 2018, Japanese, 日本リハビリテーション医学会, 福岡, Domestic conference新規低接着性コラーゲン(LASCol)はラット大腿骨骨欠損モデルにおいて骨癒合を促進するPoster presentation
- 第55回日本リハビリテーション医学会学術集会, Jun. 2018, Japanese, 日本リハビリテーション医学会, 福岡, Domestic conference経皮炭酸ガス吸収による低酸素環境の改善は乳癌骨転移モデルの骨破壊を抑制できるPoster presentation
- 第45回兵庫県核医学技術検討会, Jun. 2018, Japanese, 兵庫県核医学技術検討会, 神戸, Domestic conference運動器疾患における核医学検査の役割[Invited]Invited oral presentation
- 平成30年度阪神シニアカレッジ, Jun. 2018, Japanese, 公益財団法人兵庫県生きがい創造協会, 西宮, Domestic conference”がんを知ろう“ -怖がらずに学ぶがん診療の現実-Public discourse
- 第55回日本リハビリテーション医学会学術集会, Jun. 2018, Japanese, 日本リハビリテーション医学会, 福岡, Domestic conferenceがん性疼痛に対する経皮的電気刺激治療(TENS)の効果の検討 a pilot studyOral presentation
- 第91回日本整形外科学会学術総会, May 2018, Japanese, 日本整形外科学会, 神戸, Domestic conference明細胞肉腫におけるアミノ酸輸送体の発現 ―その病理組織診断と治療方法への応用の可能性―Poster presentation
- 第91回日本整形外科学術総会, May 2018, Japanese, 日本整形外科学会, 神戸, Domestic conference明細胞肉腫におけるアミノ酸輸送体の発現 その病理組織診断と治療方法への応用の可能性Poster presentation
- 第10回スペーサー治療研究会, May 2018, Japanese, スペーサ治療研究会, 神戸, Domestic conference骨軟部部門の経過報告と今後の展望[Invited]Invited oral presentation
- 第91回日本整形外科学術総会, May 2018, Japanese, 日本整形外科学会, 神戸, Domestic conference骨・軟部腫瘍治療における新しい医療技術の応用 ホウ素中性子捕捉療法(BNCT)を用いた肉腫治療Public symposium
- 第91回日本整形外科学術総会, May 2018, Japanese, 日本整形外科学会, 神戸, Domestic conference悪性軟部腫瘍肺転移症例における予後因子Poster presentation
- 第91回日本整形外科学会学術総会, May 2018, Japanese, 日本整形外科学会, 神戸, Domestic conferenceホウ素中性子捕捉療法（BNCT）を用いた肉腫治療Nominated symposium
- The 45th International Society for the Study of the Lumbar Spine, May 2018, English, International Society for the Study of the Lumbar Spine, Banff, International conferenceThe prospective cohort study for the predicting factor of symptomatic spinal metastasisPoster presentation
- 第91回日本整形外科学術総会, May 2018, Japanese, 日本整形外科学科, 神戸, Domestic conferenceLow-grade fibromyxoid sarcoma(Evans tumor)の臨床病理学的検討 診断におけるFUS break-apart FISHの有用性Oral presentation
- 第47回日本脊椎脊髄病学会学術集会, Apr. 2018, Japanese, 日本脊椎脊髄病学会学術集会, 神戸, Domestic conference脊椎転移に対する集学的治療は予後を延長させるOral presentation
- 第47回日本脊椎脊髄病学会, Apr. 2018, Japanese, 日本脊椎脊髄病学会, 神戸, Domestic conference脊椎転移に対する集学的治療は予後を延長させるOral presentation
- 第130回中部日本整形外科災害外科学会, Apr. 2018, Japanese, 中部日本整形外科災害外科学会, 松山, Domestic conference小児の手指に発生したchondrolipomaの1例Oral presentation
- 住吉台中自治会第10回講演会, Apr. 2018, Japanese, 住吉台中自治会, 神戸, Domestic conference健康的な生活を目指して-運動機能の維持・強化が、なぜ大切か-フレイルとロコモティブシンドロームPublic discourse
- 第8回兵庫県転移性骨腫瘍治療研究会, Mar. 2018, Japanese, 兵庫県転移性骨腫瘍治療研究会, 神戸, Domestic conference腎癌の転移性骨腫瘍に対しニボルマブが著効した一例Oral presentation
- The 64th Annual Meeting of the Orthopaedic Research Society, Mar. 2018, English, The Orthopaedic Research Society, New Orleans, USA, International conferenceAugmentation of Fracture Healing by Low Adhesive Scaffold Collagen (LASCol) in a Rat Femur Osteotomy Model.Poster presentation
- 第149回関西骨軟部腫瘍研究会, Feb. 2018, Japanese, Kansai Musculoskeletal Tumor Seminar, 大阪, Domestic conference骨盤骨腫瘍Oral presentation
- 第148回関西骨軟部腫瘍研究会, Nov. 2017, Japanese, Kansai Musculoskeletal Tumor Seminar, 大阪, Domestic conference手部軟部腫瘍の1例Oral presentation
- 第59回日本小児血液・がん学会, Nov. 2017, Japanese, 日本小児血液・がん学会, 愛媛, Domestic conferenceClinical characteristics and outcome of pediatric osteosarcoma: a single-center experienceOral presentation
- 第1回日本リハビリテーション医学会秋季学術集会, Oct. 2017, Japanese, 日本リハビリテーション医学会, 岡山, Domestic conference当院における骨転移リハビリテーションの現状とリハ介入因子の検討Oral presentation
- 第7回兵庫県転移性骨腫瘍治療研究会, Oct. 2017, Japanese, Hyogo Metastatic Bone Tumor Seminar, 神戸, Domestic conference転移性骨腫瘍に対する人工骨幹置換術Oral presentation
- The 129ｔｈ Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Oct. 2017, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 富山, Domestic conference転移性骨腫瘍に対する腫瘍用人工関節の術後成績[Invited]Nominated symposium
- The 32nd Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2017, Japanese, The Japanese Orthopaedic Association, 沖縄, Domestic conferenceThe improvement of hypoxia by Transcutaneous Carbon Dioxide (CO2) Application blocks the progressive bone destruction in breast cancer metastasis[Invited]Nominated symposium
- The 129ｔｈ Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Oct. 2017, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 富山, Domestic conference全身画像検索が診断に有用であった慢性再発性多発性骨髄炎(CRMO)の2例Oral presentation
- 第50回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2017, Japanese, 日本整形外科学会, 東京都, Domestic conference平滑筋肉腫に対するホウ素中性子補足療法（BNCT）の適応についての検討Oral presentation
- The 50th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2017, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference転移性骨腫瘍に対する腫瘍用人工関節の術後成績Poster presentation
- The 50th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2017, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference症候性脊椎転移の発生リスクに関する前向き研究Oral presentation
- The 50th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2017, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference四肢転移性骨腫瘍患者に対する理学療法の現状Oral presentation
- The 50th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2017, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conferenceThe Improvement of Hypoxia by Transcutaneous CO2 Application Blocks The Bone Destruction in Metastatic Bone TumorPoster presentation
- The 50th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2017, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference悪性軟部腫瘍肺転移に対する切除術の治療成績Oral presentation
- 第50回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2017, Japanese, 日本整形外科学会, 東京都, Domestic conference悪性トライトン腫瘍に対するホウ素中性子補足療法（BNCT）の適応についての検討Oral presentation
- The 50th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2017, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conferenceLow-grade fibromyxoid sarcoma (Evans tumor)の 診断におけるFISHの有用性Oral presentation
- The Japanese Journal of Rehabilitation Medicine, Jun. 2017, Japanese, The International Congress of Shoulder & Elbow Surgery, 岡山, Domestic conference野球選手における超音波検査を用いた筋弾性率と筋厚の評価Oral presentation
- The 54th Annual Meeting of the Japanese Association of Rehabilitation Medicine, Jun. 2017, Japanese, The International Congress of Shoulder & Elbow Surgery, 岡山, Domestic conference骨盤骨腫瘍に対して腫瘍切除後にHip transposition法を施行した2例Oral presentation
- The Japanese Journal of Rehabilitation Medicine, Jun. 2017, Japanese, The Japanese Association of Rehabilitation Medicine(JARM), 岡山, Domestic conferenceCombined Abduction Test および Horizontal Flexion Test と肩後方筋群の弾性率の関係Oral presentation
- The 90th Annual Meeting of the Japanese Orthopaedic Association, May 2017, Japanese, The Japanese Orthopaedic Association, 仙台, Domestic conference有症状脊椎転移の発生リスクに関する前向き研究Poster presentation
- The 90th Annual Meetin of the Japanese Orthopaedic Association, May 2017, Japanese, The Japanese Orthopaedic Association, 仙台, Domestic conference骨軟部悪性腫瘍における肺転移切除例の治療成績Poster presentation
- The 90th Annual Meetin of the Japanese Orthopaedic Association, May 2017, Japanese, The Japanese Orthopaedic Association, 仙台, Domestic conference骨転移診療の現状と各診療科の意識調査 整形外科医・腫瘍内科医・放射線治療医に対するアンケートOral presentation
- The 44th International Society for the Study of the Lumbar Spine, May 2017, English, The International Society for the Study of the Lumbar Spine, Athens, Greece, International conferenceThe prospective cohort study for the predicting factor of symptomatic spinal metastasisPoster presentation
- The 19th International Society of Limb Salvage General Meeting, May 2017, English, International Society of Limb Salvage General Meeting, 金沢, International conferenceThe Improvement of Hypoxia by Transcutaneous CO2 Application Blocks The Progression of Bone Destruction in Bone Metastatic Animal Model.Poster presentation
- The 19th International Society of Limb Salvage General Meeting, May 2017, English, International Society of Limb Salvage General Meeting, 金沢, International conferenceOutcomes of tumor endoprosthetic reconstruction after resection of bone metastasis.Poster presentation
- The 19th International Society of Limb Salvage General Meeting, May 2017, English, Kanazawa, Japan, International conferenceOptimaization of Anti-tumor Treatment Conditions for Transcutaneous CO2 Application in vivoPoster presentation
- The 90th Annual Meetin of the Japanese Orthopaedic Association, May 2017, Japanese, The Japanese Orthopaedic Association, 仙台, Domestic conferenceLow-grade fibromyxoid sarcoma (Evans tumor)の診断における分子遺伝学的解析の有用性Poster presentation
- The 19th International Society of Limb Salvage General Meeting, May 2017, English, International Society of Limb Salvage General Meeting, 金沢, International conferenceClinicopathological investigation and diagnostic algorithm for low-grade fibromyxoid sarcoma (Evans tumor)Poster presentation
- The 90th Annual Meetin of the Japanese Orthopaedic Association, May 2017, Japanese, The Japanese Orthopaedic Association, 仙台, Domestic conferenceChronic expanding hematomaのMRI画像の特徴と軟部肉腫との鑑別についての検討Poster presentation
- The 19th International Society of Limb Salvage General Meeting, May 2017, English, International Society of Limb Salvage General Meeting, 金沢, International conferenceBenefit of surgical treatment of pulmonary metastasis in bone and soft tissue sarcomaPoster presentation
- The 19th International Society of Limb Salvage General Meeting, May 2017, English, International Society of Limb Salvage General Meeting, 金沢, International conferenceActivation of AMPK by AICAR suppresses osteosarcoma cell growth via induction of mitochondrial apoptosisOral presentation
- The 128ｔｈ Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Apr. 2017, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 神戸, Domestic conference大腿骨に発生したFGF23産生腫瘍による腫瘍性骨軟化症の1例Oral presentation
- Asia Pacific Orthopaedic Association Trauma & Infection Meeting 2017, Apr. 2017, English, Asia Pacific Orthopaedic Association, Putrajaya, Malaysia, We have reported that topical cutaneous application of CO2 using a hydrogel accelerates fracture repair by increasing blood flow, angiogenesis and promoting endochondral ossification in rats [1]. Now we apply this novel therapy to human subjects, and assess the safety and efficacy., International conferenceTopical cutaneous application of carbon dioxide using a hydrogel is a new treatment option to accelerate fracture repair -Results of a clinical trial-Oral presentation
- ISMRM 25th Annual Meeting & Exhibition, Apr. 2017, English, international Society for Magnetic Resonance in Medicine, Honolulu, USA, In patients with normal renal function, typical linear Gd chelate, Gd-DTPA-BMA showed approximately 5.0 times more Gd accumulation in the human bone than macrocyclic Gd chelate, Gd-DOTA at a single dose application., International conferenceComparison of gadodiamide (Gd-DTPA-BMA) versus gadoterate meglumine (Gd-DOTA) of Gadolinium retention in human bone tissue in relation with renal functionOral presentation
- 第6回兵庫県転移性骨腫瘍治療研究会, Mar. 2017, Japanese, Hyogo Metastatic Bone Tumor Seminar, 神戸, Domestic conference大腿骨非定型骨折を来した乳癌の転移性骨腫瘍Oral presentation
- 第146回関西骨軟部腫瘍研究会, Feb. 2017, Japanese, Kansai Musculoskeletal Tumor Seminar, 大阪, Domestic conference骨盤骨腫瘍Oral presentation
- Advanced Breast Cancer seminar, Jan. 2017, Japanese, Advanced Breast Cancer seminar, 博多, Domestic conference当院における転移性骨腫横に対する取り組み －BMB（キャンサーボード）設立から4年－Public discourse
- 第58回日本小児血液・がん学会学術集会, Dec. 2016, Japanese, 日本小児血液・がん学会, 東京, Domestic conferenceG-CSF投与と自家末梢血幹細胞移植を併用しbi-weekly VDC-IE療法を完遂し得た切除不能ユーイング肉腫例Oral presentation
- The 31st Annual Research Meeting of the Japanese Orthopaedic Association, Nov. 2016, Japanese, The Japanese Orthopaedic Association, 博多, Domestic conference骨肉腫細胞に対するSmac模倣薬とドキソルビシンの併用効果の検討Poster presentation
- The 31st Annual Research Meeting of the Japanese Orthopaedic Association, Nov. 2016, Japanese, The Japanese Orthopaedic Association, 博多, Domestic conference骨転移部位の低酸素環境の改善は乳癌骨転移による骨破壊を抑制するPoster presentation
- 2016 Connective Tissue Oncology Society Annual Meeting, Nov. 2016, English, Connective Tissue Oncology Socisty, Lisbon, Portugal, International conferenceClinicopathological investigation of low-grade fibromyxoid sarcoma (Evans tumor)Poster presentation
- The 31st Annual Research Meeting of the Japanese Orthopaedic Association, Nov. 2016, Japanese, The Japanese Orthopaedic Association, 博多, Domestic conferenceAICARの骨肉腫細胞に対するアポトーシス誘導効果Oral presentation
- 第5回兵庫転移性骨腫瘍治療研究会, Oct. 2016, Japanese, Hyogo Metastatic Bone Tumor Seminar, 神戸, Domestic conference当院における四肢転移性骨腫瘍に対する外科的治療の現状と治療成績Oral presentation
- The 31st Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2016, Japanese, The Japanese Orthopaedic Association, 福岡, Domestic conference骨肉腫細胞に対するSmac模倣薬と抗癌剤の併用効果の検討Oral presentation
- The 127th Meeting of The Central Japan Association of Orthopaedic Surgery and Traumatology, Sep. 2016, Japanese, Meeting of The Central Japan Association of Orthopaedic Surgery, 松本, Domestic conference当院における四肢転移性骨腫瘍に対する外科的治療の現状と治療成績Oral presentation
- The 127th Meeting of The Central Japan Association of Orthopaedic Surgery and Traumatology, Sep. 2016, Japanese, Meeting of The Central Japan Association of Orthopaedic Surgery, 松本, Domestic conference腸骨に発生したchronic expanding hematomaの1例Oral presentation
- 第14回日本臨床腫瘍学会学術集会, Jul. 2016, Japanese, 日本臨床腫瘍学会, 神戸, Domestic conference本邦における脊椎転移患者の治療にかかる院内連携の現状の検討 -骨転移キャンサーボードが与える影響について-Oral presentation
- 2016 the Japanese Society of Medicla Oncology Annual Meeting, Jul. 2016, Japanese, The Japanese Society of Medical Oncology, 神戸, Domestic conference本邦における脊椎転移患者の治療にかかる院内連携の現状の検討 -骨転移キャンサーボードが与える影響について[Invited]Nominated symposium
- 第14回日本臨床腫瘍学会学術集会, Jul. 2016, Japanese, 日本臨床腫瘍学会, 神戸, Domestic conference本邦における骨転移治療の現状についてのアンケート結果の報告Oral presentation
- The 49th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association., Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference当院における転移患者に対するリハビリテーション介入因子[Invited]Nominated symposium
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference当院における骨転移患者に対するリハビリテーション介入因子[Invited]Nominated symposium
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference転移性脊椎腫瘍患者に対する理学療法の現状Poster presentation
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference低酸素環境改善は乳癌細胞において破骨細胞誘導因子と溶骨性因子の発現を低下させるPoster presentation
- The 49th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference脊椎転移に対する保存的治療と外科的治療 脊椎転移に対する手術療法の効果[Invited]Nominated symposium
- The 49th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference脊椎転移に対する手術療法の効果[Invited]Nominated symposium
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference進行骨軟部肉腫に対するゲムシタビン/ドセタキセル併用療法の治療成績Oral presentation
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference骨肉腫細胞に対するSmac模倣薬と抗癌剤の併用効果の検討Poster presentation
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference骨転移症例のリハビリ・緩和・在宅 当院における骨転移患者に対するリハビリテーション介入因子[Invited]Nominated symposium
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference悪性末梢神経鞘腫瘍（MPNST: malignant peripheral nerve sheath tumor）の治療成績.Poster presentation
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conferenceLow-grade fibromyxoid sarcoma(Evans tumor)の臨床病理学的検討Oral presentation
- 第49回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2016, Japanese, 日本整形外科学会, 東京都, Domestic conferenceLow-grade fibromyxoid sarcoma (Evans tumor)の臨床病理学的解析Oral presentation
- 2016 the Japanese Society of Medicla Oncology Annual Meeting, Jul. 2016, English, The Japanese Society of Medical Oncology, 神戸, Domestic conferenceGemcitabine and docetaxel for advanced bone and soft tissue sarcomasPoster presentation
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conferenceAICARの骨肉腫細胞に対するアポトーシス誘導効果Poster presentation
- International Society of Physical and Rehabilitation Medicine2016,, Jun. 2016, English, International Society of Physical and Rehabilitation Medicine, Kuala Lumpur, Malaysia, International conferenceManagement of The Patients With Bone Metastasis Under Bone Metastasis Cancer Board,Poster presentation
- The 89th Annual Meetin of the Japanese Orthopaedic Association, May 2016, Japanese, The Japanese Orthopaedic Association, 横浜, Domestic conference当院における四肢転移性骨腫瘍に対する外科的治療成績Poster presentation
- The 126th Meeting of the Central Japan Asscciation of Orthopaedic Surgery and Traumatology, Apr. 2016, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 浜松, Domestic conference乳幼児に股義足を作成し歩行を獲得した1例Oral presentation
- The 126th Meeting of the Central Japan Asscciation of Orthopaedic Surgery and Traumatology, Apr. 2016, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 浜松, Domestic conference乳幼児に股関節義足を作成し歩行を獲得した一例Poster presentation
- The 45th Annual Meeting of the Japanese Society for Spine Surgery and Related Research, Apr. 2016, Japanese, The Japanese Society for Spine Surgery and Related Research, 千葉, Domestic conference脊椎転移に対する集学的治療の予後改善効果（シンポジウム・ワークショップパネル）[Invited]Nominated symposium
- The 45th Annual Meeting of the Japanese Society for Spine Surgery and Related Research, Apr. 2016, Japanese, The Japanese Society for Spine Surgery and Related Research, 千葉, Domestic conference脊椎転移に対する集学的治療の予後改善効果Oral presentation
- Orthopaedic Research Society 62nd Annual Meeting 2016, Mar. 2016, English, Orthopaedic Research Society, Orland, USA, International conferenceCombination therapy of Smac mimetic and doxorubicin on osteosarcoma cellsPoster presentation
- Orthopaedic Research Society 62nd Annual Meeting 2016, Mar. 2016, English, Orthopaedic Research Society, Orland, USA, International conferenceAICAR induces Apoptosis in Human Osteosarcoma Cells through AMPK-dependent PGC-1α/TFAM/Mitochondrial PathwayPoster presentation
- 第143回関西骨軟部腫瘍研究会（臨床）, Feb. 2016, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference前腕軟部腫瘍Oral presentation
- The 26th Annual Meeting of the Japanese Pediatric Orthopaedic Association, Dec. 2015, English, The Japanese Pediatric Orthopaedic Association, 岐阜, Domestic conferenceAchievement of developmental milestones by a hip disarticulation prosthesis in infancy.- a case report -Poster presentation
- 第142回関西骨軟部腫瘍研究会（臨床）, Nov. 2015, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference左脛骨骨腫瘍の1例Oral presentation
- 第16回近畿骨軟部腫瘍談話会, Nov. 2015, Japanese, 近畿骨軟部腫瘍談話会, 大阪, Domestic conference骨盤骨腫瘍Oral presentation
- 2015 Annual Meeting of the Connective Tissue Oncology Society, Nov. 2015, English, Connective Tissue Oncology Society, Salt Lake City, USA, International conferenceApoptotic Effect of AICAR on Osteosarcoma Cell LinesOthers
- 第5回スペーサー治療研究会, Oct. 2015, Japanese, スペーサー治療研究会, 京都, Domestic conference骨盤周囲の悪性骨軟部腫瘍に対する粒子線治療‐整形外科の症例からの経験‐Oral presentation
- The 30th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2015, Japanese, The Japanese Orthopaedic Association, 富山, Domestic conference骨肉腫細胞に対するSMAC摸倣薬とドキソルビシンの併用効果Poster presentation
- The 125ｔｈ Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Oct. 2015, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 名古屋, Domestic conference後骨間神経麻痺を呈した前腕脂肪腫の一例Oral presentation
- The 30th Annual Research Meeting of the Japanese Orthopaedic Association., Oct. 2015, Japanese, Ｔhe Japanese Orthopaedic Association., 富山, Domestic conference悪性腫瘍の炭酸ガス経皮吸収の感受性の差異の検討Oral presentation
- 57th Annual Meeting of the American Society for Radiation Oncology (ASTRO), Oct. 2015, English, American Society for Radiation Oncology, San Antonio, USA, International conferenceSpinal Instability Is Associated With Local Failure After Radiation Therapy in Patients With Spinal MetastasesPoster presentation
- The 30th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2015, Japanese, The Japanese Orthopaedic Association, 富山, Domestic conferenceAICARの骨肉腫細胞に対するアポトーシス誘導効果Oral presentation
- 4th Annual Meeting Japan Association of Spine Surgeons with Ambition, Aug. 2015, Japanese, Japan Association of Spine Surgeons with Ambition, 福岡, Domestic conference脊椎転移に集学的治療の予後改善効果Oral presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conference軟部肉腫広範切除後皮膚欠損に対する遊離植皮における陰圧創傷閉鎖法併用の治療経験Poster presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conference当院における四肢転移性骨腫瘍に対する外科的治療成績Oral presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conference脊椎転移に集学的治療の予後改善効果Poster presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conference骨肉腫細胞に対するSMAC摸倣薬とドキソルビシンの併用効果Oral presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conference骨転移キャンサーボード（bone metastasis board:BMB)による転移性骨腫瘍のマネジメントPublic symposium
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conference骨巨細胞腫の治療成績Oral presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association., Jul. 2015, Japanese, Ｔhe Japanese Orthopaedic Association., 香川, Domestic conference悪性腫瘍に対する炭酸ガス経皮吸収の最適化投与条件の検討Oral presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conferenceSurvivin抑制薬"YM155"は骨肉腫細胞において腫瘍増殖を抑制するPoster presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conferenceAICARの骨肉腫細胞に対するアポトーシス誘導効果Poster presentation
- Asia Pacific Paediatric Orthopaedic Society 2015, Jun. 2015, English, Asia Pacific Paediatric Orthopaedic Society, Hong Kong, China, International conferenceEmergency hip disarticulation for a giant infantile fibrosarcoma of the lower extremity - a case report -Poster presentation
- 42nd Annual Meeting of the International Society for the Study of the Lumber Spine, Jun. 2015, English, The International Society for the Study of the Lumbar Spine, San Francisco, USA, International conferencecost-utility of surgical treatment for patients with spinal metastasisOral presentation
- The 52nd Annual Meeting of the Japanese Association of Rehabilitation Medicine, May 2015, Japanese, The Japanese Association of Rehabilitation Medicine, 新潟, Domestic conferenceＴｒｉ-Lock Bone Preservation StemのDEXAによる術後骨密度変化の検討Poster presentation
- The 52nd Annual Meeting of the Japanese Association of Rehabilitation Medicine, May 2015, Japanese, The Japanese Association of Rehabilitation Medicine, 新潟, Domestic conference様々な病態が重なり整復不能となった長腓骨筋腱脱臼の1例Poster presentation
- The 52nd Annual Meeting of the Japanese Association of Rehabilitation Medicine, May 2015, Japanese, The Japanese Association of Rehabilitation Medicine, 新潟, Domestic conference脊椎転移に集学的治療の治療成績Oral presentation
- The 88th Annual Meeting of the Japanese Orthopaedic Association, May 2015, Japanese, The Japanese Orthopaedic Association, 神戸, Domestic conference骨巨細胞腫の治療成績Oral presentation
- The 88th Annual Meeting of the Japanese Orthopaedic Association, May 2015, Japanese, The Japanese Orthopaedic Association, 神戸, Domestic conference高齢者脊椎転移に対する手術成績Poster presentation
- The 52nd Annual Meeting of the Japanese Association of Rehabilitation Medicine, May 2015, Japanese, The Japanese Association of Rehabilitation Medicine, 新潟, Domestic conference筋損傷後の治癒過程におけるｐ21の役割Oral presentation
- The 15th International Congress of Radiation Research, May 2015, English, 京都, International conferenceSpinal instability is associated with local recurrence after radiotherapy in patients with spinal metastasesPoster presentation
- The 124th Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Apr. 2015, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 金沢, Domestic conference小児の足関節内に生じた骨軟骨形成性腫瘍の1例Oral presentation
- The 44th Annual Meeting of the Japanese Society for Spine Surgery and Related Research, Apr. 2015, Japanese, The Japanese Society for Spine Surgery and Related Research, 福岡, Domestic conference骨転移専門tumor boardの取り組みOral presentation
- The 44th Annual Meeting of the Japanese Society for Spine Surgery and Related Research, Apr. 2015, Japanese, The Japanese Society for Spine Surgery and Related Research, 福岡, Domestic conference高齢者脊椎転移に対する手術成績Oral presentation
- 第74回日本医学放射線学会, Apr. 2015, English, 日本医学放射線学会, 横浜, Domestic conferencePrognostic factors for local control and survival after radiotherapy in patients with spinal metastasesOral presentation
- The 44th Annual Meeting of the Japanese Society for Spine Surgery and Related Research, Apr. 2015, Japanese, The Japanese Society for Spine Surgery and Related Research, 福岡, Domestic conferenceEuroQOL-5D（EQ-5D)を用いた転移性脊椎腫瘍に対する手術加療の費用対効用Oral presentation
- Orthopaedic Research Society 61st Annual Meeting 2015, Mar. 2015, English, Orthopaedic Research Society, Las Vegas, USA, International conferenceYM155, A Novel Small Molecule Survivin Suppressant, Reduces Tumor Progression of Human Musculoskeletal MalignanciesPoster presentation
- The Annual Meething of the European Society of Radiology, Mar. 2015, English, European Society of Radiology, Vienna, Austria, International conferenceGadolinium retention in musculoskeletal soft tissue with normal renal function; macrocyclic Gd contrast agent versus linear chelate Gd contrast agentOral presentation
- 第140 回関西骨軟部腫瘍研究会（臨床）, Feb. 2015, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference右橈骨腫瘍Oral presentation
- The 27th Annual Meeting of the Japanese society for Radiation Oncology, Dec. 2014, Japanese, The Japanese society for Radiation Oncology, 横浜, Domestic conference脊椎転移による脊髄損傷リスクの検討（第2報）Oral presentation
- 100th RSNA, Dec. 2014, English, Radiological Sociiety of North America, USA, Chicago, International conferenceComparison of Gd-DTPA-BMA versus Gd-DOTA of Gadolinium retention in human bone tissue with normal renal function. Interim Report.Oral presentation
- The 39th Annual Meeting of Japanese Society for Surgery of the Foot, Nov. 2014, Japanese, Japanese Society for Surgery of the Foot, 宮崎, Domestic conference足部に骨軟骨腫を生じた2例Poster presentation
- 100th Radiological Society of North America, Nov. 2014, English, Radiological Society of North America, Chicago, USA, International conferenceComparison of Gd-DTPA-BMA versus Gd-DOTA of Gadolinium Retention in Human Bone Tissue with Normal Renal FunctionOral presentation
- The 29th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2014, Japanese, The Japanese Orthopaedic Association, 鹿児島, Domestic conferenceReoxygenation by transcutaneous CO2 therapy decreases expressions of iPS cell-related genes in a human MFH cell linePoster presentation
- 第25回日本脊椎関節炎学会学術集会, Oct. 2014, Japanese, 日本脊椎関節炎学会, 大阪, Domestic conference坐骨結節腱付着部炎で発症した末梢性脊椎関節炎を疑う1症例Oral presentation
- The 29th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2014, Japanese, The Japanese Orthopaedic Association, 鹿児島, Domestic conferenceYM155，a Novel Small-Molecule Survivin Suppressant， Reduces Progression of human Malignant Fibrous HistiocitomaH cellsPoster presentation
- The 123rd Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Oct. 2014, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 名古屋, Domestic conference緊急的に股関節離断術を施行した乳児型線維肉腫の一例Oral presentation
- The 18th Biennial Congress of Asia Pacific Orthopaedic Association, Oct. 2014, English, Asia Pacific Ortopaedic Asociation, Pattaya, Thailand, International conferenceYM155, A Novel Small-Molecule Survivin Suppressant, Suppresses Tumor Progression With Increased Mitochondrial Apoptosis In Human Malignant Fibrous Histiocitoma.Poster presentation
- The 29th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2014, Japanese, The Japanese Orthopaedic Association, 鹿児島, Domestic conferenceMRI造影剤投与後の骨中ガドリニウム濃度についてPoster presentation
- The 29th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2014, Japanese, The Japanese Orthopaedic Association, 鹿児島, Domestic conferenceAICARの骨肉腫細胞に対するアポトーシス誘導効果Poster presentation
- The 33rd Annual Meeting of the Japanese Society for Transplantation and Tissue Engineering in Musculoskeletal System., Sep. 2014, Japanese, Japanese Society for Transplantation and Tissue Engineering in Musculoskeletal System, 東京, miR-140-3p・miR-140-5p・miR-181a-5p・miR-181d・miR-451aが骨折治癒過程において重要な役割を果たしていることが示唆された。miR-140-3p・miR-140-5p・miR-181a-5p・miR-181d・miR-451aが骨折治癒過程において重要な役割を果たしていることが示唆された。miR-140-3p・miR-140-5p・miR-181a-5p・miR-181d・miR-451aが骨折治癒過程において重要な役割を果たしていることが示唆された。, Domestic conference骨折治癒過程におけるmicroRNA発現の網羅的解析Oral presentation
- The 15th Asian Oceanian Congress of Radiology, Sep. 2014, English, Asian Oceanian Congress of Radiology, 神戸, International conferenceRetrospective analysis of risk factors influencing survival and gait disturbance in patients with spinal metastasesPoster presentation
- The 47th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2014, Japanese, The Japanese Orthopaedic Association, 大阪, Domestic conference新生児の下肢に発症した乳児線維肉腫の一例Poster presentation
- The 47th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2014, Japanese, The Japanese Orthopaedic Association, 大阪, Domestic conferenceYM155, a Novel Small-Molecule Survivin Suppressant, Reduces Progression of Human Malignant Fibrous Histiocitoma Cells.Oral presentation
- The 51th Annual Meeting of the Japanese Association of Rehabilitation Medicine, Jun. 2014, Japanese, The Japanese Association of Rehabilitation Medicine, 名古屋, Domestic conference有症性の両側第4腓骨筋腱に対する治療経験Poster presentation
- 3ｒｄ Annual Meeting Japan Association of Spine Surgeons with Ambition, Jun. 2014, Japanese, Japan Association of Spine Surgeons with Ambition, 名古屋, Domestic conference当院におけるBone Meta Boardの取り組みOral presentation
- 51st Annual Meetihg of The Japanese Association of Rehabilitation Medicine, Jun. 2014, Japanese, The Japanese Association of Rehabilitation Medicine, 名古屋, Domestic conferenceTranscutaneous CO2 Therapy Suppresses Tumor Growth and iPS-Related Gene Expressions in SarcomaOral presentation
- 51st Annual Meetihg of The Japanese Association of Rehabilitation Medicine, Jun. 2014, Japanese, The Japanese Association of Rehabilitation Medicine, 名古屋, Domestic conference大腿切断5年後に発症した断端神経腫の一例Poster presentation
- The 51th Annual Meeting of the Japanese Association of Rehabilitation Medicine, Jun. 2014, Japanese, The Japanese Association of Rehabilitation Medicine, 名古屋, Domestic conference距骨に骨軟骨腫を生じた一例Poster presentation
- 51st Annual Meetihg of The Japanese Association of Rehabilitation Medicine, Jun. 2014, Japanese, The Japanese Association of Rehabilitation Medicine, 名古屋, Domestic conferenceばね指、エコー、A1プーリーPoster presentation
- The 51th Annual Meeting of the Japanese Association of Rehabilitation Medicine, Jun. 2014, Japanese, The Japanese Association of Rehabilitation Medicine, 名古屋, Domestic conferenceG2ステム使用症例の短中期成績Poster presentation
- The 87th Annual Meeting of the Japanese Orthopaedic Association, May 2014, Japanese, The Japanese Orthopaedic Association, 神戸, Domestic conference転移性脊椎腫瘍に対する手術成績 -手術、非手術例の生命予後、全身状態、日常生活動作に関する前向き研究-[Invited]Nominated symposium
- 第87回日本整形外科学会総会学術集会, May 2014, Japanese, 日本整形外科学会, 神戸, Domestic conference炭酸ガス経皮投与は乳癌骨転移による骨破壊を抑制するOral presentation
- 第87回日本整形外科学会総会学術集会, May 2014, Japanese, 日本整形外科学会, 神戸, Domestic conference炭酸ガス経皮投与は骨・軟部肉腫におけるiPS関連遺伝子の発現を低下させるOral presentation
- The 87th Annual Meeting of the Japanese Orthopaedic Association, May 2014, Japanese, The Japanese Orthopaedic Association, 神戸, Domestic conference徐放化抗癌剤抱合血管内皮前駆細胞を用いた新しい骨肉腫治療法の開発Poster presentation
- The 87th Annual Meeting of the Japanese Orthopaedic Association, May 2014, Japanese, The Japanese Orthopaedic Association, 神戸, Domestic conference骨・軟部腫瘍 希少疾患に光明をもたらす夢の実現へ -悪性骨・軟部腫瘍に対する炭酸ガス経皮投与療法-[Invited]Nominated symposium
- 第43回日本脊椎脊髄病学会学術集会, Apr. 2014, Japanese, 日本脊椎脊髄病学会, 神戸, Domestic conference転移性脊椎腫瘍患者の手術、非手術例における生命予後、歩行状態に関する前向き研究Oral presentation
- The 122nd Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Apr. 2014, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 岡山, Domestic conference炭酸ガスと放射線併用療法による骨軟部肉腫に対する新しい治療法戦略の確立Oral presentation
- The 73rd Annual Meeting of the Japan Radiological Sociey, Apr. 2014, Japanese, The Japan Radiological Sociey, 横浜, Domestic conferenceRetrospective analysis of risk factors influencing survival and gait disturbance in patients with spinal metastasesOral presentation
- 第43回日本脊椎脊髄病学会学術集会, Apr. 2014, Japanese, 日本脊椎脊髄病学会, 神戸, Domestic conference高悪性度転移性脊椎腫瘍患者の手術例における全身状態、日常生活動作に関する前向き研究Oral presentation
- The 122nd Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Apr. 2014, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 岡山, Domestic conference巨大骨嚢胞を伴う肘関節症に対して人工肘関節置換術を行った1例Oral presentation
- 第73回日本医学放射線学会, Apr. 2014, Japanese, 日本医学放射線学会, 横浜, Domestic conferenceRetrospective analysis of risk factors influencing survival and gait disturbance in patients with spinal metastasesOral presentation
- The 73rd Annual Meeting of the Japan Radiological Sociey, Apr. 2014, Japanese, The Japan Radiological Sociey, 横浜, Domestic conferenceComparison of Gd-DTPA-BMA versus Gd-DOTA of gadolinium retention in human bone tissue work-in-progressOral presentation
- 60th Annual Meeting of Orthopaedic Research Society, Mar. 2014, English, Orthopaedic Research Society, New Orleans, USA, International conferenceYM155, A Novel Small Molecule Survivin Suppressant, Reduces Tumor Progression of Human Malignant Fibrous Histiocytoma.Poster presentation
- 60th Annual Meeting of Orthopaedic Research Society, Mar. 2014, English, Orthopaedic Research Society, New Orleans, USA, International conferenceTranscutaneous Carbon Dioxide (CO2) Therapy Suppresses Bone Destruction By Breast Cancer Metastasis With Decreased Expression Of Hypoxia-inducible Factor-1α (Hif-1α) In Vivo.Oral presentation
- 第7回金沢骨軟部腫瘍セミナー, Dec. 2013, Japanese, 金沢骨軟部腫瘍セミナー, 金沢, Domestic conference経皮的二酸化炭素吸収療法-骨軟部腫瘍に応用可能か-[Invited]Invited oral presentation
- 第55回日本小児血液・がん学会学術集会, Nov. 2013, Japanese, 日本小児血液・がん学会, 福岡, Domestic conference初診時に血管腫と鑑別を要した右下腿原発乳児線維肉腫の新生児例Poster presentation
- The 38th Annual Meeting of Japanese Society for Surgery of the Foot, Oct. 2013, Japanese, The Japanese Society for Surgery of the Foot, 仙台, Domestic conference距骨に骨軟骨腫を生じた一例Poster presentation
- The 28th annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2013, Japanese, The Japanese Orthopaedic Association, 千葉, Domestic conferenceヒト悪性線維性組織球腫株におけるSurvivin抑制によるアポトーシスの検討Oral presentation
- 8th Combined Meeting of Orthopaedic Research Societies, Oct. 2013, English, Orthopaedic Research Society, Venice, Italy, International conferenceThe effects of reoxygenation using a novel CO2 therapy on radiosensitivity in human malignant fibrous histiocytoma cells.Oral presentation
- 8th Combined Meeting of Orthopaedic Research Societies, Oct. 2013, English, Orthopaedic Research Society, Venice, Italy, International conferenceSurvivin inhibition induces mitochondrial apoptosis in human MFH cells.Oral presentation
- APOA 2013, Aug. 2013, Japanese, Asia Pacific Orthopaedic Association, Kuching, Malaysia, International conferenceBacterial knee arthritis caused by Brodie's abscess in the distal femoral epiphysis.Oral presentation
- The 50th Annual Meeting of Yhe Japanese Association of Rehabilitation Medicine, Jun. 2013, Japanese, The Japanese Association of Rehabilitation Medicine, 東京, Domestic conference乳癌細胞株を移植した動物モデルに対する経皮的炭酸ガス治療の効果Oral presentation
- The 50th Annual Meeting of Yhe Japanese Association of Rehabilitation Medicine, Jun. 2013, Japanese, The Japanese Association of Rehabilitation Medicine, 東京, Domestic conference大腿切断後の断端shrinkageに対し従来の吸着式ソケットにより良好な成績を得た1例Oral presentation
- The 50th Annual Meeting of Yhe Japanese Association of Rehabilitation Medicine, Jun. 2013, Japanese, The Japanese Association of Rehabilitation Medicine, 東京, Domestic conference骨肉腫肺転移マウスモデルに対する経皮炭酸ガス療法の効果の検討Oral presentation
- The 50th Annual Meeting of Yhe Japanese Association of Rehabilitation Medicine, Jun. 2013, Japanese, The Japanese Association of Rehabilitation Medicine, 東京, Domestic conference鏡視下腱板修復術に対する腕神経叢ブロックの術後疼痛への影響 Pain visionによる評価Oral presentation
- 第259回播但地区整形外科集談会, May 2013, Japanese, The Japanese Orthopaedic Association, 加古川, Domestic conference軟部腫瘍の診断と治療 -行ってよいこと、いけないこと-[Invited]Invited oral presentation
- The 86th Annual Meeting of the Japanese Orthopaedic Association, May 2013, Japanese, The Japanese Orthopaedic Association, 広島, Domestic conference炭酸ガス経皮投与は骨肉腫細胞の腫瘍増大と転移能を抑制するOral presentation
- The 86th Annual Meeting of the Japanese Orthopaedic Association, May 2013, Japanese, The Japanese Orthopaedic Association, 広島, Domestic conference整形外科領域におけるホウ素中性子捕捉療法(BNCT)Oral presentation
- The 86th Annual Meeting of the Japanese Orthopaedic Association, May 2013, Japanese, The Japanese Orthopaedic Association, 広島, Domestic conference阪神淡路大震災を振り返って―震災後の災害医療体制とその課題―[Invited]Nominated symposium
- The 86th Annual Meeting of the Japanese Orthopaedic Association, May 2013, Japanese, The Japanese Orthopaedic Association, 広島, Domestic conference高純度β-リン酸三カルシウム(β-TCP)を骨補填材料として使用した良性骨腫瘍の治療成績Oral presentation
- 59th Annual Meeting of the Orthopaedic Research Society, Jan. 2013, English, Orthopaedic Research Society, San Antonio, International conferenceTranscutaneous Application of CO2 Induced Mitochondrial Apoptosis in Human Malignant Tumors.Oral presentation
- 59th Annual Meeting of the Orthopaedic Research Society, Jan. 2013, English, Orthopaedic Research Society, San Antonio, International conferenceThe Effects of Reoxygenation Using a Novel CO2 Therapy on Metastatic Potentials in Osteosarcoma.Oral presentation
- 59th Annual Meeting of the Orthopaedic Research Society, Jan. 2013, English, Orthopaedic Research Society, San Antonio, International conferenceRegulation of Mitochondrial Number Induces Apoptosis in Musculoskeletal Malignancies.Oral presentation
- 59th Annual Meeting of the Orthopaedic Research Society, Jan. 2013, English, Orthopaedic Research Society, San Antonio, International conferenceDecoy Receptor 3 Regulates Migration and Invasion Abilities via Promoting MMP-2 Expression through PI3K/Akt Pathway in Human Malignant Fibrous Histiocytoma.Oral presentation
- 第23回 日本小児整形外科学会学術集会, Nov. 2012, Japanese, 日本小児整形外科学会, 福岡, Domestic conference化膿性膝関節炎をきたした骨端部Brodie膿瘍の1例Oral presentation
- The 27th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2012, Japanese, The Japanese Orthopaedic Association, 名古屋, Domestic conference炭酸ガス経皮投与療法を用いた骨・軟部肉腫に対する新しい治療法Oral presentation
- 第27回日本整形外科学会基礎学術集会, Oct. 2012, Japanese, 日本整形外科学会, 名古屋, 炭酸ガス経皮吸収により骨肉腫肺転移は有意に抑制され、その効果はMMP発現の抑制によるものと推察された, Domestic conference炭酸ガス経皮投与はMMP群の発現を抑制することで骨肉腫細胞の肺転移能を低下させるOral presentation
- 第119回中部日本整形外科災害外科学会・学術集会, Oct. 2012, Japanese, 中部日本整形外科災害外科学会, 福井, Domestic conference大腿骨遠位骨腫瘍に対する腫瘍用人工膝関節置換術後の膝蓋骨低位症の検討Oral presentation
- 第119回中部日本整形外科災害外科学会・学術集会, Oct. 2012, Japanese, 中部日本整形外科災害外科学会, 福井, Domestic conference血管柄付腓骨移植を用いて再建した足根骨骨巨細胞腫の1例Oral presentation
- The 27th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2012, Japanese, The Japanese Orthopaedic Association, 名古屋, Domestic conferenceミトコンドリア量調節による悪性骨・軟部腫瘍に対する治療の可能性Oral presentation
- The 27th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2012, Japanese, The Japanese Orthopaedic Association, 名古屋, Domestic conferenceヒトMFH細胞におけるDcR3の増殖能・遊走能・浸潤能に対する影響の検討Oral presentation
- 9TH ASIA PACIFIC MUSCULOSKELETAL TUMOUR SOCIETY MEETING, Sep. 2012, English, ASIA PACIFIC MUSCULOSKELETAL TUMOUR SOCIETY, Kuala Lumpur, International conferenceTranscutaneous Application of CO2 Induced Mitochondrial Apoptosis in Human Malignant Tumors.Oral presentation
- 9TH ASIA PACIFIC MUSCULOSKELETAL TUMOUR SOCIETY MEETING, Sep. 2012, English, ASIA PACIFIC MUSCULOSKELETAL TUMOUR SOCIETY, Kuala Lumpur, International conferenceRegulation of Mitochondrial Number Induces Cellular Apoptosis in Human Sarcomas.Oral presentation
- 第31回日本運動器移植・再生医学研究会, Sep. 2012, Japanese, 日本運動器移植・再生医学研究会, 弘前, Domestic conferenceiPS細胞の骨再生へ向けた新たな骨分化誘導法の確立Oral presentation
- 9TH ASIA PACIFIC MUSCULOSKELETAL TUMOUR SOCIETY MEETING, Sep. 2012, English, ASIA PACIFIC MUSCULOSKELETAL TUMOUR SOCIETY, Kuala Lumpur, International conferenceDecoy Receptor 3 Enhances Migration and Invasion Ability by Regulating MMP-2 and MMP-9 expression in human MFH cells.Oral presentation
- 第12回近畿Medical Oncology研究会, Aug. 2012, Japanese, 近畿Medical Oncology研究会, 大阪, Domestic conference悩む骨転移の症例[Invited]Nominated symposium
- 第45回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2012, Japanese, The Japanese Orthopedic Association, 東京, Domestic conference腓骨骨腫瘍の一例Oral presentation
- 第45回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2012, Japanese, 日本整形外科学会, 東京, Domestic conference低酸素環境の改善はヒトMFH細胞においてミトコンドリア量を増加させるOral presentation
- 第45回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2012, Japanese, 日本整形外科学会, 東京, Domestic conference炭酸ガス経皮投与療法を用いたヒトMFHに対する新しい治療法Oral presentation
- 第45回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2012, Japanese, 日本整形外科学会, 東京, Domestic conference体幹部に発生した悪性軟部腫瘍に対する治療成績Oral presentation
- 第45回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2012, Japanese, 日本整形外科学会, 東京, Domestic conference脂肪肉腫の治療成績Oral presentation
- 第45回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2012, Japanese, 日本整形外科学会, 東京, Domestic conferenceガドリニウム(Gd)中性子捕捉療法(Gd-NCT)用Gd含有ナノ粒子の腫瘍内直接投与による腫瘍制御の可能性Oral presentation
- 第45回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2012, Japanese, 日本整形外科学会, 東京, Domestic conferenceDcR3はMMP発現を介してヒトMFH細胞の遊走能および浸潤能を抑制するOral presentation
- 第49回日本リハビリテーション医学会学術集会, May 2012, Japanese, 日本リハビリテーション医学会, 福岡, 低酸素濃度下による骨肉腫細胞のMMP産生能に関する検討, Domestic conference骨肉腫細胞における酸素環境の変化に伴うマトリックスメタロプロテアーゼ2及び9の発現変化についての検討Oral presentation
- The 85th Annual Meeting of the Japanese Orthopaedic Assosiation, May 2012, Japanese, The Japanese Orthopaedic Association, 京都, Domestic conferenceDcR3発現抑制はMFH細胞において細胞遊走能および浸潤能を抑制し、FasLによるアポトーシスを亢進させるOral presentation
- 第45回日本整形外科学会 骨・軟部腫瘍学術集会, Apr. 2012, Japanese, 中部日本整形外科災害外科学会, 大阪, Domestic conference腓骨骨腫瘍の1例[Invited]Invited oral presentation
- 第118回中部日本整形外科災害外科学会, Apr. 2012, Japanese, 中部日本整形外科災害外科学会, 大阪, Domestic conference胸壁悪性軟部腫瘍に対する治療成績Oral presentation
- 58st Annual Meeting of the Orthopaedic Research Society, Jan. 2012, English, Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceTranscutaneous application of CO2 induced mitochondrial apoptosis in human malignant fibrous histiocytoma.Oral presentation
- 58th Annual Meeting of the Orthopaedic Research Society, Jan. 2012, English, Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceTranscutaneous application of CO2 enhanced radiosensitivity in human malignant histiocytoma cells in vivoOral presentation
- 58th Annual Meeting of the Orthopaedic Research Society, Jan. 2012, English, Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceSilencing of decoy receptor 3 enhances FasL induced apoptosis and decreases migration and invasion ability in human MFH cells.2Oral presentation
- 58th Annual Meeting of the Orthopaedic Research Society, Jan. 2012, English, Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceProtein kinase D1 negatively regulates invasion and migration ability of human osteosarcoma cellsOral presentation
- 58th Annual Meeting of the Orthopaedic Research Society, Jan. 2012, English, Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceMitochondrial proliferation induces apoptosis of human malignant fibrous histiocytomaOral presentation
- 第38回日本臨床バイオメカニクス学会, Nov. 2011, Japanese, 日本臨床バイオメカニクス学会, 神戸, Domestic conference人工股関節イメージマッチングとその課題Others
- 第38回日本臨床バイオメカニクス学会, Nov. 2011, Japanese, 日本臨床バイオメカニクス学会, 神戸, Domestic conferenceACL再建術前後の膝安定性評価―電磁気センサーを用いたpivot shift test、Lachman testの非侵襲的解析―Oral presentation
- 第26回 日本整形外科学会基礎学術集会, Oct. 2011, Japanese, 日本整形外科学会, 前橋, Domestic conference悪性線維性組織球腫細胞株に対する血管新生阻害剤ベバシズマブの効果Oral presentation
- 第26回 日本整形外科学会基礎学術集会, Oct. 2011, Japanese, 日本整形外科学会, 前橋, Domestic conferenceヒト悪性線維性組織球腫細胞株におけるDecoy receptor 3の抗アポトーシス作用およびFas ligandによるアポトーシス誘導に関する検討Oral presentation
- 16th 2011Combined Meeting of Connective Tissue Oncology Society and the Musculoskeletal Tumor Society, Oct. 2011, English, Combined Meeting of Connective Tissue Oncology Society and the Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceRegeneration of mitochondrial proliferation by PGc-1a induces apoptosis in human MHF cellsOral presentation
- 第26回 日本整形外科学会基礎学術集会, Oct. 2011, Japanese, 日本整形外科学会, 前橋, Domestic conferenceProtein Kinase C-deltaのヒトMFH細胞に対するアポトーシスへの影響についての検討Oral presentation
- 第26回 日本整形外科学会基礎学術集会, Oct. 2011, Japanese, 日本整形外科学会, 前橋, Domestic conferencePGC-1α過剰発現によるミトコンドリアの増殖はMFHにおいてアポトーシスを促進するOral presentation
- 16th 2011Combined Meeting of Connective Tissue Oncology Society and the Musculoskeletal Tumor Society, Oct. 2011, English, Combined Meeting of Connective Tissue Oncology Society and the Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceDecoy receptor 3 inhibits apoptosis and promotes cell migration in human malignant fibrous histiocytoma cellsOral presentation
- 16th 2011Combined Meeting of Connective Tissue Oncology Society and the Musculoskeletal Tumor Society, Oct. 2011, English, Combined Meeting of Connective Tissue Oncology Society and the Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceClinical outcome of additional wide excision for patients with malignant soft tissue tumorsOral presentation
- 第30回日本運動器移植・再生医学研究会, Sep. 2011, Japanese, 日本運動器移植・再生医学研究会, 福岡, Domestic conference良性骨腫瘍切除後骨欠損に対する高純度β-リン酸三カルシウム（β-TCP）充填の治療成績Oral presentation
- 第436回整形外科集談会京阪神地方会, Sep. 2011, Japanese, 整形外科集談会京阪神地方会, 大阪, Domestic conference大腿切断後に断端神経腫を発症した1例Oral presentation
- 57th South African Orthopaedic Association Congress, Sep. 2011, English, South African Olthopacdic Association, Sun City, South Africa, International conferenceNatural history of the healing potential of PCL Injury in the multiple ligament injured knee[Invited]Invited oral presentation
- 57th South African Orthopaedic Association Congress, Sep. 2011, English, South African Olthopacdic Association, Sun City, South Africa, International conferenceMy approach to the acute dislocated knee[Invited]Invited oral presentation
- The 2011 European Multidisciplinary Cancer Congress, Sep. 2011, English, Europe Canser organization, ストックホルム, スウェーデン, International conferenceMitochondrial proliferation induces apoptosis in human MFH cells by PGC-1 alpha overexpressionOral presentation
- The 2011 European Multidisciplinary Cancer Congress, Sep. 2011, English, Europe Canser organization, ストックホルム, スウェーデン, International conferenceAnti-apoptotic effect of decoy receptor 3 in human malignant fibrous histiocytoma cellsOral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conference術後に局所再発を来した軟部肉腫の検討Oral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conference悪性軟部腫瘍に対する追加広範囲切除の治療成績Oral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conference悪性線維性組織球腫細胞株に対する血管新生阻害剤ベバシズマブの効果Oral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conference悪性線維性組織球腫における増殖因子や細胞内シグナル伝達経路の働きOral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conferenceホウ素中性子捕捉療法(BNCT)を用いた明細胞肉腫に対する新しい治療方法Oral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conferenceヒト悪性線維性組織球腫細胞株におけるdecoy receptor 3の抗アポトーシス作用に関する検討Oral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conferenceヒトMFH細胞株におけるprotein kinase C-deltaのアポトーシスへの影響についての検討Oral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conferenceProtein kinase D1は骨肉腫細胞においてMMP-2およびMMP-9の発現を制御して抗腫瘍効果を示すOral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conferenceMFHに対するsurvivinを標的とした分子標的治療の可能性Oral presentation
- 第84回日本整形外科学会学術総会, May 2011, Japanese, 日本整形外科学会学, 横浜, Domestic conference分化型脂肪肉腫の治療成績Oral presentation
- 第84回日本整形外科学会学術総会, May 2011, Japanese, 日本整形外科学会学, 横浜, Domestic conference骨・軟部腫瘍におけるprotein kinase D1の発現についての検討Oral presentation
- 第46回日本理学療法学術大会, May 2011, Japanese, 日本理学療法学術会, 宮崎, Domestic conference悪性骨腫瘍に伴う大腿骨病的骨折に対して創外固定術後に腫瘍用人工膝関節置換術を施行した就学児童の一症例 自立歩行獲得までの経緯Oral presentation
- 第84回日本整形外科学会学術総会, May 2011, Japanese, 日本整形外科学会学, 横浜, Domestic conferenceSurvivinはMFHに対する治療の標的になりうるOral presentation
- 第84回日本整形外科学会学術総会, May 2011, Japanese, 日本整形外科学会, 横浜, Domestic conferenceSIRT1阻害による骨・軟部肉腫に対する細胞増殖抑制効果Oral presentation
- 第116回中部日本整形外科災害外科学会, Apr. 2011, Japanese, 中部日本整形外科災害外科学会, 高知, Domestic conference幼児の大腿骨骨端部骨髄炎の一例 X線、MR所見の経時的変化Oral presentation
- 第6回兵庫県学術研修フォーラム, Dec. 2010, Japanese, なし, 神戸, Domestic conference骨軟部腫瘍の画像診断Others
- 第127回関西骨軟部腫瘍研究会, Nov. 2010, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference右前腕軟部腫瘍Oral presentation
- CTOS 16th Annual Meeting, Nov. 2010, English, Connective Tissue Oncology Society, パリ, フランス, International conferenceThe Effect of Bevacizumab (Avastin) in Combination with Doxorubicin on Tumor Growth of Malignant Fibrous Histiocytoma in the Animal Model.Poster presentation
- CTOS 16th Annual Meeting, Nov. 2010, English, Connective Tissue Oncology Society, パリ, フランス, International conferenceClinical outcome of patients with malignant fibrous histiocytoma in the soft tissueOral presentation
- 第115回中部日本整形外科災害外科学会, Oct. 2010, Japanese, 中部日本整形外科災害外科学会, 大阪, Domestic conference脛骨神経に発生したintraneural hemangiomaの1例Oral presentation
- 第25回日本整形外科学会 基礎学術集会, Oct. 2010, Japanese, 日本整形外科学会, 京都, Domestic conference骨・軟部腫瘍におけるprotein kinase D1の作用についての検討Poster presentation
- 第25回日本整形外科学会 基礎学術集会, Oct. 2010, Japanese, 日本整形外科学会, 京都, Domestic conference骨・軟部腫瘍におけるprotein kinase C-deltaの細胞増殖に関する役割についての検討Poster presentation
- 第25回日本整形外科学会 基礎学術集会, Oct. 2010, Japanese, 日本整形外科学会, 京都, Domestic conference骨・軟部悪性腫瘍におけるSIRT1の発想とその阻害による抗腫瘍効果Poster presentation
- 第25回日本整形外科学会 基礎学術集会, Oct. 2010, Japanese, 日本整形外科学会, 京都, Domestic conferenceマウス悪性線維性組織球腫(MFH)モデルに対する血管新生阻害剤ベバシズマブとドキソルビシンの併用療法の効果についてPoster presentation
- 第25回日本皮膚外科学会総会・学術集会, Sep. 2010, Japanese, 日本皮膚外科学会, 別府, Domestic conferencePosterior Thigh Flapにて再建し得た重粒子線治療による難治性皮膚潰瘍の1例Oral presentation
- 第43回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2010, Japanese, 日本整形外科学会, 東京, Domestic conference明細胞肉腫に対するホウ素中性子捕捉療法を用いた新たな治療方法開発の試みOral presentation
- 第43回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2010, Japanese, 日本整形外科学会, 東京, Domestic conference腹壁外デスモイドの治療成績Oral presentation
- 第43回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2010, Japanese, 日本整形外科学会, 東京, Domestic conference骨・軟部腫瘍におけるprotein kinase D1の発現についての検討Oral presentation
- 第43回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2010, Japanese, 日本整形外科学会, 東京, Domestic conference骨・軟部腫瘍におけるprotein kinase C-deltaの細胞増殖に関する役割についての検討Oral presentation
- 第43回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2010, Japanese, 日本整形外科学会, 東京, Domestic conference悪性線維性組織球腫細胞株に対する血管新生阻害剤bevacizumabの効果Oral presentation
- 第43回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2010, Japanese, 日本整形外科学会, 東京, Domestic conference悪性線維性組織球腫の治療成績Oral presentation
- 第43回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2010, Japanese, 日本整形外科学会, 東京, Domestic conference悪性腫瘍と鑑別を要した肩甲背部に発生した骨化性筋炎の1例Poster presentation
- 第43回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2010, Japanese, 日本整形外科学会, 東京, Domestic conferenceマウス悪性線維性組織球腫(MFH)モデルに対する血管新生阻害剤bevacizumabとdoxorubicinの併用療法の効果についてOral presentation
- 第430回整形外科集談会京阪神地方会, Jun. 2010, Japanese, 中部日本整形外科災害外科学会, 大阪, Domestic conference下垂足で発症した神経内ガングリオンの1例Oral presentation
- 21st Meeting of the European Association for Cancer Research, Jun. 2010, English, European Association for Cancer Research, オスロ, ノルウェー, International conferenceThe Effect of Bevacizumab on Intratumoral Angiogenesis of Malignant Fibrous Histiocytoma in Animal Model.Poster presentation
- 21st Meeting of the European Association for Cancer Research, Jun. 2010, English, European Association for Cancer Research, オスロ, ノルウェー, International conferenceRole of Protein Kinase C δ in Musculoskeletal Tumors.Poster presentation
- 第125回関西骨軟部腫瘍研究会, May 2010, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference脛骨骨腫瘍の1例Oral presentation
- 第114回中部日本整形外科災害外科学会, Apr. 2010, Japanese, 中部日本整形外科災害外科学会, 名古屋, Domestic conference化膿性関節炎をきたした骨端部Brodie膿瘍の2例Poster presentation
- 56th Annual Meeting of the Orthopaedic Research Society, Mar. 2010, English, The Orthopaedic Research Society, ニューオリンズ, アメリカ, International conferenceThe Effect of Bevacizumab on Intratumoral Angiogenesis of Malignant Fibrous Histiocytoma in Animal ModelOral presentation
- 56th Annual Meeting of the Orthopaedic Research Society, Mar. 2010, English, The Orthopaedic Research Society, ニューオリンズ, アメリカ, International conferenceROLE OF PROTEIN KINASE C d IN MUSCULOSKELETAL TUMORSOral presentation
- 第122回関西骨軟部腫瘍研究会, Nov. 2009, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference後頚部軟部腫瘍Oral presentation
- 第123回関西骨軟部腫瘍研究会, Nov. 2009, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference肩甲背部腫瘍Oral presentation
- 第24回日本整形外科学会 基礎学術集会, Nov. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conferenceマウス悪性線維性組織球腫(MFH)モデルにおける血管新生阻害剤bevacizumabの効果の検討Oral presentation
- 第24回日本整形外科学会 基礎学術集会, Nov. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conferenceMFH細胞株に対する血管新生阻害剤bevacizumabの効果Oral presentation
- 第113回中部日本整形外科災害外科学会, Oct. 2009, Japanese, 中部日本整形外科災害外科学会, 神戸, Domestic conference高純度β-TCPを用いた良性骨腫瘍に対する術後成績Public symposium
- 兵庫県膝関節研究会, Sep. 2009, Japanese, 兵庫県膝関節研究会, 神戸, Domestic conference特発性膝関節血症の2症例Oral presentation
- 第426回整形外科集談会京阪神地方会, Sep. 2009, Japanese, なし, 大阪, Domestic conference特発性膝関節血腫症の2症例Oral presentation
- ISOLS/MSTS combined meeting, Sep. 2009, English, International Symposium of Limb Salvage/Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceTreatment of fibrous dysplasiaOral presentation
- ISOLS/MSTS combined meeting, Sep. 2009, English, International Symposium of Limb Salvage/Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceThe Effect of Bevacizumab (Avastin) on Tumor Growth of Malignant Fibrous Histiocytoma in the Animal ModelOral presentation
- ISOLS/MSTS combined meeting, Sep. 2009, English, International Symposium of Limb Salvage/Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceProtein kinase delta expression in musculoskeletal tumorsOral presentation
- ISOLS/MSTS combined meeting, Sep. 2009, English, International Symposium of Limb Salvage/Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceOncologic and functional outcome of malignant pelvic bone tumors after carbon iron radiotherapyOral presentation
- ISOLS/MSTS combined meeting, Sep. 2009, English, International Symposium of Limb Salvage/Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceEffect of angiogenesis inhibitor PTK787 for malignant fibrous histiocytoma in vitroOral presentation
- 第24回神戸市北区整形外科医会, Jul. 2009, Japanese, 神戸市北区整形外科医会, 神戸, Domestic conference軟部腫瘍の診断と治療Invited oral presentation
- 第42回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conference脱神経筋萎縮を伴った悪性末梢神経鞘腫瘍の2例Oral presentation
- 第42回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conference骨盤悪性腫瘍に対する重粒子線治療後の患肢機能評価Public symposium
- 第42回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conference骨・軟部悪性腫瘍に対するsecond line化学療法としてのICE療法Oral presentation
- 第42回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conference激烈な坐骨神経痛を呈しPETにより検出しえた坐骨神経内結節性筋膜炎の1例Oral presentation
- 第42回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conference悪性軟部腫瘍との鑑別を要したchronic expanding hematomaの2例Oral presentation
- 第42回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conference悪性軟部腫瘍MFHにおけるスフィンゴシンキナーゼの発現および細胞増殖への検討Oral presentation
- 第42回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conferenceマウス悪性線維性組織球腫(MFH)モデルにおける血管新生阻害剤bevacizumabの効果の検討Oral presentation
- 第112回中部日本整形外科災害外科学会, Apr. 2009, Japanese, 中部日本整形外科災害外科学会, 京都, Domestic conference悪性軟部腫瘍との鑑別を要したchronic expanding hematomaの2例Oral presentation
- 第424回整形外科集談会京阪神地方会, Mar. 2009, Japanese, なし, 大阪, Domestic conference上腕骨近位骨端部に発生したランゲルハンス細胞組織球症の1例Oral presentation
- 第422回整形外科集談会京阪神地方会, Mar. 2009, Japanese, なし, 大阪, Domestic conferencePyogenic granulomaの一例Oral presentation
- 脊椎外科を学ぶ会, Feb. 2009, Japanese, なし, 大阪, Domestic conference胸椎椎体の急速破壊をきたした腫瘍類似疾患の1例Oral presentation
- 55th Annual Meeting of the Orthopaedic Research Society, Feb. 2009, English, The Orthopaedic Research Society, ラスベガス, アメリカ, International conferenceThe Expressions of Sphingosine Kinase-1 in Human Malignant Fibrous Histiocytoma (MFH) Cell Lines, and the Role of Sphingosine Kinase-2 in Growth of MFH Cell LinesOral presentation
- 55th Annual Meeting of the Orthopaedic Research Society, Feb. 2009, English, The Orthopaedic Research Society, ラスベガス, アメリカ, International conferenceThe Effect of Bevacizumab (Avastin) on Tumor Growth of Malignant Fibrous Histiocytoma in the Animal Model.Oral presentation
- 第91回神戸甲状腺研究会, Feb. 2009, Japanese, なし, 神戸, Domestic conferenceMetastasizing thyroid noduleの２例Oral presentation
- 55th Annual Meeting of the Orthopaedic Research Society, Feb. 2009, English, The Orthopaedic Research Society, ラスベガス, アメリカ, International conferenceEffect of siRNA for DcR4 on Apoptosis in Osteosarcoma cells.Oral presentation
- 第23回日本整形外科学会 基礎学術集会, Oct. 2008, Japanese, 日本整形外科学会, 京都, Domestic conference血管新生抑制剤 bevacizumabの悪性線維性組織球腫(MFH)に対するin vivoでの効果Oral presentation
- 第23回日本整形外科学会 基礎学術集会, Oct. 2008, Japanese, 日本整形外科学会, 京都, Domestic conference悪性骨・軟部腫瘍の脂質代謝経路におけるEDGレセプターおよびスフィンゴシンキナーゼの検討Oral presentation
- 第23回日本整形外科学会 基礎学術集会, Oct. 2008, Japanese, 日本整形外科学会, 京都, Domestic conferenceヒト骨肉腫細胞株に対するAKT inhibitorによる抗腫瘍効果の検討Oral presentation
- 第11１回中部日本整形外科災害外科学会, Oct. 2008, Japanese, 中部日本整形外科災害外科学会, 金沢, Domestic conferenceBenign lipoblastomaの2例Oral presentation
- 第41回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2008, Japanese, 日本整形外科学会, 浜松, Domestic conference大腿骨開放骨折後に発症したintraosseous epidermoid cystの1例Oral presentation
- 第41回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2008, Japanese, 日本整形外科学会, 浜松, Domestic conference若年者骨・軟部悪性腫瘍に対する末梢血幹細胞移植を併用した超大量化学療法Oral presentation
- 第41回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2008, Japanese, 日本整形外科学会, 浜松, Domestic conference骨盤悪性腫瘍に対する重粒子線治療の治療成績Oral presentation
- 第41回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2008, Japanese, 日本整形外科学会, 浜松, Domestic conference骨・軟部腫瘍株におけるsiRNAを用いたDcR3抑制効果Oral presentation
- 第41回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2008, Japanese, 日本整形外科学会, 浜松, Domestic conference悪性骨・軟部腫瘍におけるEDGレセプターおよびスフィンゴシンキナーゼの発現の検討Oral presentation
- 第41回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2008, Japanese, 日本整形外科学会, 浜松, Domestic conferenceガドリニウム中性子捕捉療法を目指したMRIによる腫瘍細胞株へのMRI造影剤の付着取り込みの評価Oral presentation
- 兵庫県マイクロサージェリー研究会, May 2008, Japanese, 兵庫県マイクロサージェリー研究会, 神戸, Domestic conference橈骨骨肉腫に対して血管柄付き腓骨移植術を利用した治療Oral presentation
- 第81回日本整形外科学会学術集会, May 2008, Japanese, 日本整形外科学会, 札幌, Domestic conference悪性骨・軟部腫瘍の脂質代謝経路におけるEDGレセプターおよびスフィンゴシンキナーゼの検討Oral presentation
- 第51回日本手の外科学会, Apr. 2008, Japanese, 第51回日本手の外科学会, つくば, Domestic conference術中体外照射と超音波を併用した前腕悪性腫瘍の治療Oral presentation
- 第110回中部日本整形災害外科学会, Apr. 2008, Japanese, 第110回中部日本整形災害外科学会, 大津, Domestic conference手指に発生したグロームス腫瘍Oral presentation
- 第110回中部日本整形外科災害外科学会, Apr. 2008, Japanese, 中部日本整形外科災害外科学会, 大津, Domestic conference手指に発生したグロームス腫瘍Oral presentation
- 第110回中部日本整形外科災害外科学会, Apr. 2008, Japanese, 中部日本整形外科災害外科学会, 大津, Domestic conference関節内血腫を来した膝関節内神経鞘腫の１例Oral presentation
- 54thAnnualMeetingoftheOrthopaedicResearchSociety, Mar. 2008, English, The Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceThe Expressions of EDG Receptors and Sphigosine Kinases in Malignant Bone and Soft Tissue Tumors.Poster presentation
- 54thAnnualMeetingoftheOrthopaedicResearchSociety, Mar. 2008, English, The Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceMRI Contrast Agents in Malignant Fibrous Histiocytoma (MFH) for Gadolinium Neutron Capture Therapy (Gd-NCT).Poster presentation
- 54thAnnualMeetingoftheOrthopaedicResearchSociety, Mar. 2008, English, The Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceEffect of angiogenesis inhibitor PTK787 for MFH in vitro.Poster presentation
- The1stCongreeoftheIndonesianMusculoskeletalTumorSociety, Jan. 2008, English, The Indonesian Musculoskeletal Tumor Society, スラバヤ, インドネシア, International conferenceUsing of Megaprosthesis for Malignant Bone Tumors: Experience in Kobe University Hospital.Invited oral presentation
- The1stCongreeoftheIndonesianMusculoskeletalTumorSociety, Jan. 2008, English, The Indonesian Musculoskeletal Tumor Society, スラバヤ, インドネシア, International conferenceManagement of GCTInvited oral presentation
- 第113回関西骨軟部腫瘍研究会, Nov. 2007, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference右大腿軟部腫瘍Oral presentation
- 第109回中部日本整形外科災害外科学会, Oct. 2007, Japanese, 中部日本整形外科災害外科学会, 奈良, Domestic conference超音波療法が術中体外照射した骨に有効であった2症例Oral presentation
- 第22回日本整形外科学会基礎学術集会, Oct. 2007, Japanese, 日本整形外科学会, 浜松, Domestic conference骨・軟部腫瘍におけるDcR3の検討Poster presentation
- 第22回日本整形外科学会基礎学術集会, Oct. 2007, Japanese, 日本整形外科学会, 浜松, Domestic conferenceヒト骨・軟部肉腫細胞株に対するRaf-1 Kinase Inhibitorによる抗腫瘍効果の検討Poster presentation
- 第22回日本整形外科学会基礎学術集会, Oct. 2007, Japanese, 日本整形外科学会, 浜松, Domestic conferenceMRIを用いたMRI造影剤の腫瘍細胞株における付着・取り込み特性の評価-ガドリニウム中性子捕捉療法を目指して-Poster presentation
- 第22回日本整形外科学会基礎学術集会, Oct. 2007, Japanese, 日本整形外科学会, 浜松, Domestic conferenceMFH細胞株に対する血管新生阻害剤PTK787の効果Oral presentation
- 14thInternationalsymposiumonlimbsalvage, Sep. 2007, English, International symposium on limb salvage, ハンブルグ, ドイツ, International conferenceVEGF and angiogenesis in bone and soft tissue tumors.Oral presentation
- 14thInternationalsymposiumonlimbsalvage, Sep. 2007, English, International symposium on limb salvage, ハンブルグ, ドイツ, International conferenceTreatment for giant cell tumorOral presentation
- 第40回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2007, Japanese, 日本整形外科学会, 甲府, Domestic conference線維性骨異形成の治療成績Oral presentation
- 第40回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2007, Japanese, 日本整形外科学会, 甲府, Domestic conference骨盤腫瘍の1例Oral presentation
- 第40回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2007, Japanese, 日本整形外科学会, 甲府, Domestic conference骨・軟部腫瘍におけるDcR3の検討Oral presentation
- 第40回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2007, Japanese, 日本整形外科学会, 甲府, Domestic conferenceヒト骨・軟部肉腫細胞株に対するRaf-1 Kinase Inhibitorによる抗腫瘍効果の検討Poster presentation
- 第40回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2007, Japanese, 日本整形外科学会, 甲府, Domestic conferenceKotz型腫瘍用人工膝関節破損に対する再手術例の検討Oral presentation
- 第40回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2007, Japanese, 日本整形外科学会, 甲府, Domestic conferenceIn vitroでのMFHに対する血管新生阻害剤PTK787の効果Poster presentation
- 第80回日本整形外科学会学術集会, May 2007, Japanese, 日本整形外科学会, 神戸, Domestic conference孤立性骨嚢腫の治療成績Poster presentation
- 第80回日本整形外科学会学術集会, May 2007, English, 日本整形外科学会, 神戸, Domestic conferenceImatinib mesylate inhibit tumorigenicity of malignant fibrous histiocytoma cells in vivo.Poster presentation
- 第108回中部日本整形外科災害外科学会, Apr. 2007, Japanese, 中部日本整形外科災害外科学会, 広島, Domestic conference当科における腱鞘巨細胞腫の治療成績Oral presentation
- 第109回関西骨軟部腫瘍研究会, Feb. 2007, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference右脛骨骨腫瘍Oral presentation
- 53rd Annual Meeting of the Orthopaedic Research Society, Feb. 2007, English, 米国整形外科基礎学会, サンディエゴ, International conferenceVEGF AND ANGIOGENESIS IN BONE AND SOFT TISSUE TUMORS.Poster presentation
- 53rd Annual Meeting of the Orthopaedic Research Society, Feb. 2007, English, 米国整形外科基礎学会, サンディエゴ, International conferenceINHIBITION OF PLATELET-DERIVED GROWTH FACTOR RECEPTORS AND C-KIT PHOSPHORYLATION OF MALIGNANT FIBROUS HISTIOCYTOMA CELLS BY IMATINIB MESYLATE DOES AFFECT TUMORIGENICITY IN VIVO.Poster presentation
- 53rd Annual Meeting of the Orthopaedic Research Society, Feb. 2007, English, 米国整形外科基礎学会, サンディエゴ, International conferenceEFFECT OF RAF-1 KINASE INHIBITOR ON HUMAN BONE AND SOFT TISSUE SARCOMA CELL LINES.Poster presentation
- 53rd Annual Meeting of the Orthopaedic Research Society, Feb. 2007, English, 米国整形外科基礎学会, サンディエゴ, International conferenceDcR3 EXPRESSES IN BONE AND SOFT TISSUE TUMORS.Poster presentation
- 第108回関西骨軟部腫瘍研究会, Nov. 2006, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference右前腕軟部腫瘍Oral presentation
- 第21回日本整形外科学会 基礎学術集会, Oct. 2006, Japanese, 日本整形外科学会, 長崎, Domestic conference骨髄間葉系細胞に対するMRI造影剤の影響Poster presentation
- 第21回日本整形外科学会 基礎学術集会, Oct. 2006, Japanese, 日本整形外科学会, 長崎, Domestic conference骨・軟部腫瘍におけるVEGFと血管新生Poster presentation
- 第21回日本整形外科学会 基礎学術集会, Oct. 2006, Japanese, 日本整形外科学会, 長崎, Domestic conference骨・軟部腫瘍におけるDcR3発現の検討Poster presentation
- 第107回中部日本整形外科災害外科学会, Oct. 2006, Japanese, 中部日本整形外科災害外科学会, 神戸, Domestic conferenceMRIで偶然に発見された初期骨梗塞Oral presentation
- 第107回関西骨軟部腫瘍研究会, Sep. 2006, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference骨盤骨腫瘍Oral presentation
- 第39回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2006, Japanese, 日本整形外科学会, 札幌, Domestic conference骨巨細胞腫の治療成績Public symposium
- 第39回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2006, Japanese, 日本整形外科学会, 札幌, Domestic conference骨・軟部腫瘍におけるVEGFと血管新生Oral presentation
- 第39回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2006, Japanese, 日本整形外科学会, 札幌, Domestic conference骨・軟部腫瘍におけるDcR3の検討Oral presentation
- 第39回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2006, Japanese, 日本整形外科学会, 札幌, Domestic conference悪性線維性組織球腫における肝細胞増殖因子の免疫組織化学的検討Oral presentation
- 第39回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2006, Japanese, 日本整形外科学会, 札幌, Domestic conferenceプロテインキナーゼインヒビターPKC412のヒト骨・軟部悪性腫瘍細胞株に対する細胞増殖阻害作用の検討Oral presentation
- 第39回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2006, Japanese, 日本整形外科学会, 札幌, Domestic conferenceMRI造影剤のイヌの骨髄間葉系細胞に対する影響についてOral presentation
- 第106回関西骨軟部腫瘍研究会, Jun. 2006, Japanese, 関西骨軟部腫瘍研究会, 豊中, Domestic conference右大腿骨骨腫瘍再発Oral presentation
- 第106回中部日本整形外科災害外科学会, Apr. 2006, Japanese, 中部日本整形外科災害外科学会, 大阪, Domestic conference骨巨細胞腫の治療成績Oral presentation
- 52nd annual meeting of the Orthopaedic Research Society., Mar. 2006, English, 米国整形外科基礎学会, シカゴ, International conferenceINHIBITORY EFFECT OF PKC412 ON CELL PROLIFERATION OF HUMAN BONE AND SOFT TISSUE SARCOMA CELL LINES.Poster presentation
- 52th Annual Meeting of the Orthopaedic Research Society, Mar. 2006, English, Orthopaedic Research Society, シカゴ, International conferenceINHIBITORY EFFECT OF PKC412 ON CELL PROLIFERATION OF HUMAN BONE AND SOFT TISSUE SARCOMA CELL LINES.Oral presentation
- 第104回関西骨軟部腫瘍研究会, Feb. 2006, Japanese, 関西骨軟部腫瘍研究会, 吹田, Domestic conference左大腿骨骨腫瘍Oral presentation
- 第412回整形外科集談会京阪神地方会, Feb. 2006, Japanese, 日本整形外科学会, 大阪, Domestic conferenceFibrous hamartoma of infancyの1例Oral presentation
- 第105回中部日本整形外科災害外科学会, Oct. 2005, Japanese, 中部日本整形外科災害外科学会, 米子, Domestic conference足趾に発生した骨外性軟骨腫の2例Oral presentation
- 第20回日本整形外科学会 基礎学術集会, Oct. 2005, Japanese, 日本整形外科学会, 伊勢, Domestic conference骨軟部腫瘍におけるVEGF受容体の発現Oral presentation
- 第20回日本整形外科学会 基礎学術集会, Oct. 2005, Japanese, 日本整形外科学会, 伊勢, Domestic conference骨・軟部腫瘍におけるVEGF receptorの発現Oral presentation
- 第102回関西骨軟部腫瘍研究会, Oct. 2005, Japanese, 関西骨軟部腫瘍研究会, 豊中, Domestic conference右鼠径部軟部腫瘍Oral presentation
- 第406回整形外科集談会京阪神地方会, Sep. 2005, Japanese, 整形外科集談会京阪神地方会, 大阪, Domestic conference正中神経に発生したplexiform schwannomaの1例Oral presentation
- 第38回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2005, Japanese, 日本整形外科学会, 横浜, Domestic conference背部軟部腫瘍の1例Oral presentation
- 第38回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2005, Japanese, 日本整形外科学会, 横浜, Domestic conference軟部MFHにおけるTransforming Growth Factor-βとその受容体の発現Oral presentation
- 第38回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2005, Japanese, 日本整形外科学会, 横浜, Domestic conference上腕二頭筋長頭腱内ガングリオンの1例Oral presentation
- 第38回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2005, Japanese, 日本整形外科学会, 横浜, Domestic conference悪性線維性組織球腫における炎症性サイトカイン発現の免疫組織化学的検討Oral presentation
- 第38回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2005, Japanese, 日本整形外科学会, 横浜, Domestic conferenceプロテインキナーゼインヒビターPKC412のヒト骨軟部悪性腫瘍細胞株に対する細胞増殖阻害作用の検討Oral presentation
- 第38回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2005, Japanese, 日本整形外科学会, 横浜, Domestic conferenceMRI造影剤のヒト腫瘍細胞株への影響についてOral presentation
- 第101回関西骨軟部腫瘍研究会, Jun. 2005, Japanese, 関西骨軟部腫瘍研究会, 豊中, Domestic conference頚部軟部腫瘍Oral presentation
- 第78回日本整形外科学会学術集会, May 2005, Japanese, 日本整形外科学会, 横浜, Domestic conference脂肪肉腫の治療成績Oral presentation
- 第104回中部日本整形外科災害外科学会, Apr. 2005, Japanese, 中部日本整形外科災害外科学会, 大阪, Domestic conference左環指に発生した滑膜性骨軟骨腫症の一例Oral presentation
- 第404回整形外科集談会京阪神地方会, Mar. 2005, Japanese, 整形外科集談会京阪神地方会, 大阪, Domestic conferenceBicipitoradial bursitis（上腕二頭筋腱橈骨滑液包炎）と鑑別が困難であった粘液腫の一例Oral presentation
- 第99回関西骨軟部腫瘍研究会, Feb. 2005, Japanese, 関西骨軟部腫瘍研究会, 豊中, Domestic conference左股関節軟部腫瘍Oral presentation
- 51th Annual Meeting of the Orthopaedic Research Society, Feb. 2005, English, Orthopaedic Research Society, ワシントン, International conferenceINHIBITORY EFFECT OF STI571 ON CELL PROLIFERATION OF HUMAN MALIGNANT FIBROUS HISTIOCYTOMA CELL LINESOral presentation
- 第395回整形外科集談会京阪神地方会, Dec. 2004, Japanese, 整形外科集談会京阪神地方会, 大阪, Domestic conference若年者の大腿部に発生した孤立性線維性腫瘍の1例Oral presentation
- 第103回中部日本整形外科災害外科学会, Nov. 2004, Japanese, 中部日本整形外科災害外科学会, 神戸, Domestic conference手指に発生した多発腱鞘巨細胞腫の2例Oral presentation
- 第98回関西骨軟部腫瘍研究会, Nov. 2004, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference骨盤・右大腿骨骨腫瘍Oral presentation
- 第97回関西骨軟部腫瘍研究会, Oct. 2004, Japanese, 関西骨軟部腫瘍研究会, 豊中, Domestic conference左大腿骨骨腫瘍Oral presentation
- 第19回日本整形外科学会 基礎学術集会, Oct. 2004, Japanese, 日本整形外科学会, 東京, Domestic conferenceTNF-a およびsphingosine-1-phosphateによる骨肉腫細胞におけるapoptosis誘導と細胞増殖への影響Oral presentation
- 7th International Conference of Anticancer Research, Oct. 2004, English, Anticancer Research, コルフ, International conferenceInhibitory effect of ST1571 on cell proliferation of human malignant fibrous histiocytoma cell lines.Oral presentation
- 7th International Conference of Anticancer Research, Oct. 2004, English, Anticancer Research, コルフ, International conferenceExpression of glial cell line-derived neurotrophic factor family in peripheral nerve sheath tumors.Oral presentation
- 7th International Conference of Anticancer Research, Oct. 2004, English, Anticancer Research, コルフ, International conferenceEstablishment and characterization of a c-kit positive and SCF-producing cell line, KTHOS, derived from human osteosarcoma.Oral presentation
- 5th Combined Meeting of the Orthopaedic Research Societies of Canada, USA, Japan and Europe, Oct. 2004, English, Orthopaedic Research Society, バンフ, International conferenceEffects of TNF-alpha, sphingosine-1-phosphate, and ceramide on proliferation and apoptosis in the cells of osteosarcoma and MFH cell lines.Oral presentation
- 第３７回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2004, Japanese, 日本整形外科学会, 東京, Domestic conference良性骨腫瘍切除後の骨欠損にたいする高純度b-TCP充填術の術後成績Oral presentation
- 第３７回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2004, Japanese, 日本整形外科学会, 東京, Domestic conference軟部悪性線維性組織球腫における血小板由来増殖因子の免疫組織化学的検討Oral presentation
- 第３７回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2004, Japanese, 日本整形外科学会, 東京, Domestic conference脱分化型脂肪肉腫10例の臨床病理学的検討Public symposium
- 第３７回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2004, Japanese, 日本整形外科学会, 東京, Domestic conferenceチロシンキナーゼインヒビターSTI571のヒト悪性線維性組織球腫由来細胞株に対する細胞増殖阻害作用の検討Oral presentation
- 第３７回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2004, Japanese, 日本整形外科学会, 東京, Domestic conferenceGastrointestinal Stromal Tumor(GIST)様分化を示した脱分化型軟骨肉腫の1例Oral presentation
- 第400回整形外科集談会京阪神地方会, Jun. 2004, Japanese, 整形外科集談会京阪神地方会, 大阪, Domestic conference骨軟骨腫による上腕二頭筋長頭腱炎の一例Oral presentation
- 第96回関西骨軟部腫瘍研究会, Jun. 2004, Japanese, 関西骨軟部腫瘍研究会, 豊中, Domestic conference右大腿骨骨病変、右膝軟部腫瘍Oral presentation
- Society for Biomaterials World Congress, May 2004, English, Australian Society for Biomaterials (ASB), シドニー, International conferenceEFFECT OF CYCLIC MECHANICAL STRETCH AND TITANIUM PARTICLES ON PROSTAGRANDIN E2 PRODUCTION BY HUMAN MACROPHAGES IN VITRO.Oral presentation
- 第95回関西骨軟部腫瘍研究会, Apr. 2004, Japanese, 関西骨軟部腫瘍研究会, 豊中, Domestic conference左大腿骨骨腫瘍Oral presentation
- 第102回中部日本整形外科災害外科学会, Mar. 2004, Japanese, 中部日本整形外科災害外科学会, 松山, Domestic conferencePhalangeal Microgeodic Syndromeの2例Oral presentation
- 50th Annual Meeting of the Orthopaedic Research Society, Mar. 2004, English, Orthopaedic Research Society, サンフランシスコ, International conferenceEFFECT OF CYCLIC MECHANICAL STRETCH AND TITANIUM PARTICLES ON PROSTAGRANDIN E2 PRODUCTION BY HUMAN MACROPHAGES IN VITRO.Oral presentation
- 第94回関西骨軟部腫瘍研究会, Feb. 2004, Japanese, 関西骨軟部腫瘍研究会, 豊中, Domestic conference仙骨骨腫瘍Oral presentation
- 第93回関西骨軟部腫瘍研究会, Nov. 2003, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference両大腿骨骨病変Oral presentation
- 第18回日本整形外科学会 基礎学術集会, Oct. 2003, Japanese, 日本整形外科学会, 北九州, Domestic conference骨・軟部腫瘍におけるc-kit遺伝子発現の検討Poster presentation
- 第18回日本整形外科学会 基礎学術集会, Oct. 2003, Japanese, 日本整形外科学会, 北九州, Domestic conference機械的刺激とチタン合金粒子刺激によるマクロファージ様細胞のPGE2産生への影響Oral presentation
- 第18回日本整形外科学会 基礎学術集会, Oct. 2003, Japanese, 日本整形外科学会, 北九州, Domestic conference悪性線維性組織球腫由来細胞株のチロシンキナーゼインヒビターSTI571(メシル酸イマチニブ)に対する感受性の検討Oral presentation
- 第18回日本整形外科学会 基礎学術集会, Oct. 2003, Japanese, 日本整形外科学会, 北九州, Domestic conferenceCeramide及びSphingosine-1-phosphateによる骨軟部腫瘍細胞におけるApoptosis誘導と細胞増殖への影響Poster presentation
- 第36回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2003, Japanese, 日本整形外科学会, 神戸, Domestic conference背部弾性線維腫の細胞診所見Poster presentation
- 第36回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2003, Japanese, 日本整形外科学会, 神戸, Domestic conference軟部病変に対するfine-needle aspiration biopsyの有用性Oral presentation
- 第36回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2003, Japanese, 日本整形外科学会, 神戸, Domestic conference当科における骨軟部腫瘍術後感染症例の治療成績Public symposium
- 第36回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2003, Japanese, 日本整形外科学会, 神戸, Domestic conference左肩軟部腫瘍の1例Oral presentation
- 第36回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2003, Japanese, 日本整形外科学会, 神戸, Domestic conference高齢者に発症した軟部肉腫の治療成績Oral presentation
- 第36回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2003, Japanese, 日本整形外科学会, 神戸, Domestic conference股関節固定術後に発生し,骨盤壁を穿破した巨大な腸腰筋滑液包炎の1例Poster presentation
- 第36回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2003, Japanese, 日本整形外科学会, 神戸, Domestic conference悪性組織球腫由来細胞株のMethotrexate(MTX)に対する感受性の検討Poster presentation
- 第390回整形外科集談会京阪神地方会, Jun. 2003, Japanese, 整形外科集談会京阪神地方会, 大阪, Domestic conference大腿骨に発生した骨膜性骨芽細胞腫の1例Oral presentation
- 第100回中部日本整形外科災害外科学会, Apr. 2003, Japanese, 中部日本整形外科災害外科学会, 京都, Domestic conference妊婦に発生した脂肪肉腫の治療経験Oral presentation
- 第91回関西骨軟部腫瘍研究会, Mar. 2003, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference右肩軟部腫瘍Oral presentation
- 第89回関西骨軟部腫瘍研究会, Feb. 2003, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference右大腿骨骨腫瘍Oral presentation
- 49th Annual Meeting of the Orthopaedic Research Society, Feb. 2003, English, Orthopaedic Research Society, ニューオーリンズ, International conferenceGene expression of endothelial differentiation gene (EDG) receptors and effect of sphingosine 1-phosphate and ceramide on proliferation in the cells of musculoskeletal tumors.Poster presentation
- 日本サルコーマ治療研究学会Sep. 2017 - Present
- 日本臨床腫瘍学会Dec. 2014 - Present
- 日本運動器移植・再生医学研究会Sep. 2011 - Present
- American Academy of Orthopaedic SurgeonsApr. 2011 - Present
- 日本癌治療学会Apr. 2009 - Present
- 日本骨軟部肉腫治療研究会Apr. 2009 - Present
- 日本リハビリテーション医学会Apr. 2009 - Present
- International Skeletal SocietyJan. 2008 - Present
- Orthopaedic Research SocietyJan. 2001 - Present
- Society for BiomaterialsJul. 2000 - Present
- 中部日本整形外科災害外科学会Apr. 1993 - Present
- 日本整形外科学会Jun. 1992 - Present
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2024 - 31 Mar. 2027Effects of an antioxidant flavonoid on muscle atrophy associated with cachexia in pediatric osteosarcoma
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2022 - 31 Mar. 2025地域在住高齢がんサバイバーコホートの構築：健康寿命延伸に向けて
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2022 - 31 Mar. 2025サルコペニアの骨格筋に対する経皮的炭酸ガス投与法の効果について
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Kobe University, 09 Jul. 2021 - 31 Mar. 2024Basic research about fluid-fluid phase separation and membraneless organelles in sarcoma2021年度（令和3年度）においては、既に細胞株として市販されている細胞株および当研究室で樹立した細胞株（骨肉腫：KHOS, KTHOS, MG63, SaOS2, LM8 軟部肉腫細胞株：TNMY-1, Nara-H, Nara-F, GBS-1 ユーイング肉腫細胞株：SK-ES-1, RD-ES）を細胞を継代培養し、実験に供するための準備を行った。これらの細胞株をsubconfluentな状態で細胞を回収し、先行研究で報告されているストレス顆粒関連蛋白であるTIA-1 (T-cell-restricted intracellular antigen-1), TIAR (TIA-1-related protein), G3BP1 (RAS GTPase-activating protein-binding protein 1), G3BP2 (RAS GTPase-activating protein-binding protein 2) , CAPRIN-1 (Cell Cycle associated protein 1) , USP10 (Ubiquitin carboxyl-terminal hydrolase 10)の遺伝子発現を定性的および定量的に評価するため、mRNAの抽出とcDNAライブラリーの作成を行った。
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2021 - 31 Mar. 2024Development of new treatment strategies for osteosarcoma using induced osteosarcoma stem cells本研究の目的は，骨軟部肉腫におけるがん幹細胞研究を推進すべく，我々が作製に初めて成功した人工骨肉腫幹細胞を用いて，骨肉腫の腫瘍発生・増生，再発・転移，治療抵抗性に関わる因子を解明し，新規治療標的の同定および治療戦略の開発を行うことである． ヒト骨肉腫由来細胞株MG63にレトロウイルスベクターを用いて，OCT3/4，KLF4，SOX2の3つの遺伝子を導入した人工骨肉腫幹細胞MG-OKSとコントロール細胞MG-GFPを作製し，MG-OKS細胞において幹細胞関連マーカーの上昇，細胞増殖能の低下，細胞遊走能の上昇， スフェア形成能の上昇など，幹細胞としての特性を確認した．人工骨肉腫幹細胞MG-OKS，コントロールMG-GFP，親細胞MG-63をmicroarrayを用いて網羅的遺伝子解析を行ったところ，MG-OKS細胞においてMG-GFPおよびMG-63よりも10倍以上発現の上昇がみられた遺伝子が200個以上検出された．同遺伝子群の機能解析をGene ontologyを用いて行ったところ，主に骨肉腫との関連が考えられている上皮系分化・増生に関わる遺伝子がMG-OKSで発現上昇していることが確認された．現在解析にて確認された発現上昇遺伝子群について，治療標的になりうる因子の検討を行っている．
- 日本学術振興会, 科学研究費助成事業 基盤研究(B), 基盤研究(B), 神戸大学, 01 Apr. 2019 - 31 Mar. 2023老化の防止に挑む運動の理論的基盤の構築とその応用による運動模倣薬の開発老化の防止を目指すための運動の理論的基盤の構築と、その応用による運動模倣薬の開発を目的に、先ず運動機能に関わる骨格筋・骨・関節軟骨・脳に対する最も効果的な運動量を運動の種類（有酸素運動・レジスタンス運動）別に検討した。老齢動物は若齢動物と比べて個体差が大きく、また運動の直接的な影響に老化の影響が加わることで、得られる情報がばらつき複雑になる。これらを避けるため、若齢マウスを用いた。マウスに異なる強度の有酸素運動（トレッドミル走行）あるいはレジスタンス運動（ラダートレーニング）を1回または長期間行わせ、各組織での応答を評価した。その結果、骨格筋では、20 m/minの有酸素運動が骨格筋代謝に重要なPGC-1α発現量を最も増加させ、また体重の120%の負荷のレジスタンス運動がタンパク質合成と筋肥大に最も効果があることが明らかとなった。骨では中等度の有酸素運動が骨形成の増加と骨吸収の減少を引き起こし、骨量と強度を増加させることが明らかとなった。関節軟骨では低強度の有酸素運動が細胞外基質タンパク質を増加させ、関節軟骨の合成の効果があることが明らかとなった。脳では中等度の有酸素運動によってBDNFタンパク量が増加した一方で、レジスタンス運動では変化しないことが明らかとなった。以上により、骨格筋・骨・関節軟骨・脳にとって最も好ましい効果をもたらす適度な運動強度を同定した。次に運動の分子機序の全容を明らかにするために、この適度な強度の運動を行わせた後、運動の最たる効果器である骨格筋を対象に、遺伝子発現の変化をRNA-seqで、エピジェネティクスの変化をRRBS法で網羅的に解析した。その結果、遺伝子発現増加・脱メチル化および遺伝子発現抑制・メチル化に関わる2つの分子を同定した。今後は、これらの結果から運動模倣薬のターゲットとなる候補物質を同定し、運動模倣薬の開発実験を行う予定である。
- 学術研究助成基金助成金／基盤研究(C), Apr. 2018 - Mar. 2021Competitive research funding
- 学術研究助成基金助成金／基盤研究(C), Apr. 2017 - Mar. 2021Competitive research funding
- 学術研究助成基金助成金／挑戦的研究（萌芽）, Apr. 2017 - Mar. 2020, Principal investigatorCompetitive research funding
- 日本学術振興会, 学術研究助成基金助成金／基盤研究(C), 基盤研究(C), 神戸大学, Apr. 2017 - Mar. 2020がん性疼痛はがん患者のQOLを大きく損なう症状の一つであり、適切な鎮痛剤の使用によりコントロールできると報告されている。しかし、オピオイドなどの薬物療法では、嘔気・嘔吐、眠気、便秘、呼吸抑制などの副作用により患者の日常生活やQOLに悪影響を及ぼすリスクが高い。近年、非侵襲的で安価な鎮痛手段として経皮的電気刺激治療（TENS）ががん性疼痛の軽減に有効であることが報告されている。本研究では、がん性疼痛を有する患者に対して、従来の理学療法のみ実施する対照群と、理学療法＋TENSを実施する介入群を比較することにより、がん性疼痛に対するTENSの鎮痛効果を検証するとともに、疼痛の緩和に伴う患者の身体活動量、身体機能、QOLの改善への有効性について検証することを目的としている。 平成29～令和3年度において、がん性疼痛を有する患者30名（男性20名、女性10名、平均66.7±10.3歳）をリクルートし、介入群15名と対照群15名にランダムに割り付けを行い、研究を実施した。オピオイド使用量、疼痛の程度、身体活動量（平均歩数）、握力、膝伸展筋力、QOL（EORTC QLQ C-30）を評価項目とし、baseline（開始前）、1週後、2週後、3週後に評価を実施した。1週後、2週後、3週後の各評価項目のbaselineからの変化率を算出し、二元配置分散分析にて2群間の比較を行った。 結果として、オピオイド使用量は、介入群で1週後（-17.4±17.7% vs 13.2±27.6%, p<.01）、2週後（-33.1±23.5% vs 3.4±23.8%, p<.01）、3週後（-40.9±22.9% vs 4.0±24.3%, p<.01）に有意に減少した。身体活動量、握力、膝伸展筋力は介入群で1週後、2週後、3週後に有意に向上した。疼痛の程度とQOLには有意な差は認めなかった。 がん性疼痛に対してTENSを実施することにより、オピオイド使用量が減少し、身体活動量が増加、身体機能が改善していることから、がん性疼痛への補助療法の一つとしてTENSの有用性が示唆されている。Competitive research funding
- 科学研究費補助金／基盤研究(B), Apr. 2014 - Mar. 2018, Principal investigatorCompetitive research funding
- 学術研究助成基金助成金／基盤研究(C), Apr. 2014 - Mar. 2017Competitive research funding
- 学術研究助成基金助成金／基盤研究(C), Apr. 2014 - Mar. 2017Competitive research funding
- 国立大学法人岡山大学, 革新的がん医療実用化研究事業, 2017, Coinvestigator高悪性度骨軟部腫瘍に対する標準治療確立のための研究Competitive research funding
- 学術研究助成基金助成金／基盤研究(C), Apr. 2013 - Mar. 2016Competitive research funding
- 科学研究費補助金／萌芽研究, Apr. 2012 - Mar. 2015, Principal investigatorCompetitive research funding
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 2010 - 2012Clear cell sarcoma (CCS) of tendons and aponeuroses is a rare malignant tumor of poor prognosis,with a predilection for youngadults.Although the standard treatment is still wide surgical resection, neither chemotherapy norradiotherapy is effective. Therefore, clearly new therapeutic strategies are required. Recently, boron neutron capture therapy (BNCT) with the use of p-boronophenylalanine (BPA) for malignant melanoma has provided good results. BecauseBPA is requisite for the production of melanin, boron is finally accumulated in tumor cells. CCS also produces melanin, and with the use of a cultured human CCS cell line andthrough human CCS-bearing animal studies, we have shown that the high accumulation of 10B is potentially favorable in BNCT. Therefore, we evaluated the short-term efficacy of BNCT for CCS with the use of human CCS cell line-bearing nude mice and have here, for thefirst time, demonstrated that BNCT is a potentially new option for the treatment of human CCS.Competitive research funding
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 2010 - 2012This study proposed a quasi-optimal channel selection method and a prototype training system for a prosthetic hand control. A five-fingered prosthetic hand was also developed and controlled based on electromyogram (EMG) signalsCompetitive research funding
- 日本学術振興会, 科学研究費補助金／萌芽研究, 萌芽研究, 神戸大学, 2006 - 2007中性子捕捉療法は、腫瘍部に集積した放射線増感剤に熱中性子線を照射して放射線を放出させ腫瘍を死滅させようとする方法である。ガドリニウムもそのような放射線増感剤の一つで有るが、骨・軟部腫瘍の診断の際に使用する核磁器共鳴装置(MRI)の造影剤としても使用されるため、診断と治療が同時に行える可能性を有している。しかし、骨・軟部腫瘍についての研究報告はほとんどなされていない。そこで、本研究では、先ず、培養した悪性線維性組織球腫の細胞株にガドリニウムを作用させ細胞塊を作成し、その取り込みをMRI上で評価が可能かどうか検討した。ガドリニウムとしては、臨床で一般的に使用されているGd-DTPAおよびGd-DTPAを高濃度に含有したキトサンナノ粒子を用いて、MRIの画像上の変化を調べた。すると、MRIにてガドリニウムにより細胞塊の信号が変化することが確認できた。そして、信号強度からT1値を算出したところGd-DTPA、およびGd-DTPAを含有したキトサンナノ粒子は共にT1値を低下させ、その効果は、Gd-DTPAの方が大きいことが明らかとなった。しかし、細胞塊のガドリニウムの含有量の計測では、Gd-DTPAを含有したキトサンナノ粒子を作用させた細胞塊の方がより大きかった。この結果から、腫瘍細胞が高濃度にガドリニウムを取り込んだ場合は、MRI上では信号変化が少なくなりガドリニウムよる腫瘍の増強効果が低下することが示唆され、MRI上で診断と治療を同一に行うためにはその信号変化について今後更なる検討が必要だと考えられた。Competitive research funding
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 2005 - 2007, Principal investigatorWe have established TNMY cell lines from the retrieved MFH. We tested the effects of PTK787 (inhibitor for VEGF receptors) on cell proliferation, invasion, angiogenesis of Nara H, Nara F, GBS-1, and TNMY.) We have not found the inhibitory effect of PTK787 on cell proliferation of MFH cell lines. Cell invasion of Nara H cells was inhibited by PTK787. All four cell lines showed inhibitory effects of PTK787 on angiogenesis. In the study of DcR3 decoy receptors related to apoptosis, inhibitory effect of siRNA on mRNA expression of DcR3 could be detected in osteosarcoma and MFH cell lines. The extent of protein expression in MFH cells was higher than that in osteosarcoma cells after siRNA treatment for DcR3. In osteosarcoma cells, the number of TUNEL positive cells after siRNA+FasL treatment was same as that after contral siRNA+FasL treatment, but the number of TUNEL positive cells after siRNA+FasL+adriamycin treatment was higher than that after contral siRNA+FasL+adriamycin treatment, indicating that siRNA+FasL+adriamycin treatment induced apoptosis in osteosarcoma cells. In the study of Sphingosine-1-posphate (S1P) and EDG receptors for S1P in sarcomas, we found that mRNA expression of EDG1, 3, and 5 in high-grade sarcomas was higher than that in low-grade sarcomas. Expression of Sphingosine kinase 2 (SPHK2) in low-grade sarcomas was higher that that in high-grade sarcomas, whereas we did not find the difference in mRNA expression of SPHK1 between low-grade and high-grade sarcomas We produced Ad-OC-TK gene probes for clinical application at CPC cell culture center in Gene Medicine Japan and we tested the quality and security of probes for clinical use. The results of the tests were excellent for clinical use of Ad-OC-TK gene probes.Competitive research funding
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 2005 - 2006INTRODUCTION: RNA interference (RNAi) has recently emerged as an important biological strategy for gene silencing. The efficacy of RNAi mediated by Small Interfering RNAs (siRNAs) has been reported in nucleus pulposus cells in vitro using the exogenous reporter gene. We also reported the efficacy of micro-bubble enhanced ultrasound gene transfer (US gene transfer) to the disc in vivo. On the other hand, successful down regulation of endogenous gene by RNAi has not been reported. The objective of this study was 1) to demonstrate that specific gene expression can be suppressed in vivo by small interfering RNA (siRNA) mediated by US gene transfer, 2) to down regulate the expression of FasL, one of the genes reported to be endogenously expressed in NP cells. METHODS : 1) Two reporter luciferase plasmids (Firefly and Renilla) were used. These plasmids were co-transfected with siRNA targeting Firefly luciferase to the disc in vivo. The inhibitory effects were evaluated by dual luciferase assay for two weeks. 2) siRNA designed to specifically down regulate FasL were used. These siRNAs were transfected using the lipofection method. Seven days after transfection in vitro, cells were harvested and FasL expression was evaluated by western blotting. The house keeping gene (tubulin) expression was used as the internal control and non silencing siRNA was used for the negative control. The inhibitory ratio of the FasL expression against tubulin expression was calculated. RESULTS: 1) In the experimental group, the expression of Firefly luciferase was drastically inhibited in vivo. 2) At seven days, siRNA transfected group showed FasL expression was drastically down regulated in vitro compared with tubulin expression.Competitive research funding