Research activity information

• Prognostic Utility of Nodular Calcification Detected on Non-Contrast Computed Tomography in Severely Calcified Coronary Lesions.

  Seigo Iwane, Takayoshi Toba, Hiroyuki Kawamori, Takashi Hiromasa, Yuto Osumi, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Hiroshi Tsunamoto, Kotaro Higuchi, Hiroya Okamoto, Yu Izawa, Hiroyuki Yamamoto, Tomofumi Takaya, Ken-Ichi Hirata, Hiromasa Otake

  BACKGROUND: Nodular calcification (NC) detected via intracoronary imaging is associated with adverse cardiovascular events after percutaneous coronary intervention (PCI). However, the impact of NC detected on pre-PCI non-contrast computed tomography (CT) on clinical outcomes has not been fully investigated. METHODS AND RESULTS: We retrospectively included 267 consecutive patients with chronic coronary syndrome who underwent electrocardiography-gated non-contrast CT before PCI for severely calcified lesions. The primary outcome was major adverse cardiac and cerebrovascular events (MACCE), a composite of all-cause death, stroke, non-fatal myocardial infarction, and target lesion revascularization (TLR). Fifty-eight patients had NC detected on non-contrast CT in target lesions. The MACCE-free survival rate was significantly lower in patients with than without NC (P<0.001). All-cause death, cardiac death, and TLR-free survival rates were significantly lower among patients with than without NC. Multivariate Cox regression analysis revealed that hemodialysis (hazard ratio [HR] 3.00; P=0.003), peripheral artery disease (HR 2.65; P=0.01), and the presence of NC (HR 5.25; P<0.001) were independently associated with MACCE. Adding NC to traditional cardiovascular risk factors, peripheral artery disease, and hemodialysis can provide discriminatory and reclassification abilities in predicting MACCE. CONCLUSIONS: NC detected on non-contrast CT was independently associated with MACCE. Therefore, evaluating NC using preprocedural non-contrast CT may be useful in predicting future clinical outcomes after PCI.

  Jul. 2025, Circulation journal : official journal of the Japanese Circulation Society, 89(8) (8), 1172 - 1181, English, Domestic magazine

  Scientific journal


• Prognostic significance of angiography-derived index of microcirculatory resistance assessment after rotational atherectomy in patients with severely calcified lesions

  Yuki Sakamoto, Hiroyuki Kawamori, Takayoshi Toba, Satoru Sasaki, Hiroyuki Fujii, Tomoyo Hamana, Yuto Osumi, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Koshi Matsuhama, Yuta Fukuishi, Hiroshi Tsunamoto, Hiroya Okamoto, Kotaro Higuchi, Ken-ichi Hirata, Hiromasa Otake

  Springer Science and Business Media LLC, Jul. 2025, Heart and Vessels

  Scientific journal


• Clinical anatomy of the right intercostal arteries: Another neighbor to know before pulmonary vein isolation.

  Kei Honde, Yu Izawa, Takayoshi Toba, Hiromi Hashimura, Kyle Adlaka, Toshio Makita, Koji Fukuzawa, Ken-Ichi Hirata, Shumpei Mori

  BACKGROUND: Hemothorax caused by a right intercostal artery (ICA) injury behind the left atrium (LA) is a potentially fatal complication during pulmonary vein isolation. However, their anatomic relationship has not been fully elucidated. OBJECTIVE: This study aimed to investigate the clinical anatomy of the right ICA in relation to the LA. METHODS: This retrospective study included 100 patients (70.2 ± 10.6 years; 39.0% female) who underwent cardiac computed tomography. The patients were divided into sinus rhythm and atrial fibrillation groups. We focused on the distance between the LA and right ICAs and its predictive factors. RESULTS: On average, 3.7 ± 0.7 right ICAs were found behind the LA. Of these, the eighth ICA was the closest in 54% of the cases, followed by the seventh ICA in 29% and the ninth ICA in 14%. The average closest distance between them was 3.8 ± 3.8 mm, which was significantly shorter in the atrial fibrillation group than in the sinus rhythm group (3.0 ± 3.2 mm vs 4.7 ± 4.2 mm; P = .006). Multivariate analysis revealed that a thinner chest cavity (β = -0.512; P = .002) and LA dilation (β = -0.432; P = .001) were predictors of shorter distance. The closest points distributed along the vertebral column, generally near the inferior pulmonary vein orifices. CONCLUSION: Right ICA-LA proximity was systematically clarified. Particularly in cases with an enlarged LA or thin chest cavity, operators should be aware of the potential risk of injuring the right ICA during pulmonary vein isolation.

  Jul. 2025, Heart rhythm, 22(7) (7), e92-e102, English, International magazine

  Scientific journal


• Tunnel-Like Calcification on a Coronary Leaflet - A Warning Sign in Transcatheter Aortic Valve Replacement.

  Yuto Osumi, Takayoshi Toba, Yu Izawa, Yoichiro Sugizaki, Hiroyuki Kawamori, Hiromasa Otake

  Jun. 2025, Circulation journal : official journal of the Japanese Circulation Society, 89(7) (7), 997 - 997, English, Domestic magazine

  Scientific journal


• Diagnostic utility of velocity ratio for paradoxical low-flow/low-gradient aortic stenosis.

  Shun Nagai, Takayoshi Toba, Yu Izawa, Kei Honde, Ken-Ichi Hirata, Hidekazu Tanaka

  BACKGROUND: Calcification score by cardiac computed tomography (CT) is required for diagnosis of paradoxical low-flow/low-gradient (PLFLG) aortic stenosis (AS). According to the guideline, velocity ratio (VR) < 0.25 by echocardiography is defined as severe AS, but utility of VR in patients with PLFLG AS remains unknown. This retrospective study was therefore conducted to investigate the utility of VR for a diagnosis of severe AS based on CT in patients with PLFLG AS. METHODS: We studied 58 patients with PLFLG AS. Severity of AS was defined as calcium score derived from cardiac CT. RESULTS: Of the 58 patients, 28 (48.3%) were diagnosed with severe AS based on CT, while 23 of them (82.1%) had VR < 0.25. It was noteworthy that receiver operating characteristic curve analysis showed that the optimal VR cutoff value for a diagnosis of severe AS was 0.25, with an area under the curve of 0.870 (P < 0.001). Sensitivity, specificity, positive predictive value, and negative predictive value of VR < 0.25 for a diagnosis of severe AS were 82.1%, 86.7%, 85.2% and 83.9%, respectively. Furthermore, patients who match the value of VR and severity of AS based on CT had higher prevalence of atrial fibrillation, higher serum brain natriuretic peptide concentration, larger left ventricular end-diastolic volume, and left ventricular stroke volume index. CONCLUSION: The measurement of VR is simple, and VR < 0.25 can be used for diagnosis of patients with PLFLG AS as severe. Our findings may thus have clinical implications for routine clinical practice.

  Mar. 2025, Journal of echocardiography, 23(1) (1), 41 - 47, English, Domestic magazine

  Scientific journal


• Understanding Cardiac Anatomy and Imaging to Improve Safety of Procedures: The Femoral Artery and Vein: Part 1.

  Takanori Sato, Shumpei Mori, Peter Hanna, Aron Bender, Justin Hayase, Shili Xu, Akiharu Yoshioka, Shintaro Yamagami, Takayoshi Toba, Yu Izawa, Kalyanam Shivkumar

  We revisit and show comprehensive femoral access site anatomy with a combination of images obtained from detailed cadaveric dissection, fluoroscopy, computed tomography, ultrasound, and 3-dimensional printings. Part 1 focuses on the femoral triangle, femoral bifurcation, fluoroscopic and/or ultrasonographic anatomy, and branches of the femoral artery. Profound understanding of this region is fundamental to facilitate safe procedures and to avoid unnecessary complications.

  Dec. 2024, JACC. Case reports, 29(23) (23), 102807 - 102807, English, International magazine

  Scientific journal


• Understanding Cardiac Anatomy and Imaging to Improve Safety of Procedures: The Femoral Artery and Vein: Part 2.

  Takanori Sato, Shumpei Mori, Peter Hanna, Aron Bender, Justin Hayase, Shili Xu, Akiharu Yoshioka, Shintaro Yamagami, Takayoshi Toba, Yu Izawa, Kalyanam Shivkumar

  This paper revisits and shows comprehensive femoral access site anatomy with a combination of images obtained from detailed cadaveric dissection, fluoroscopy, computed tomography, ultrasound, and 3-dimensional printings. Part 2 focuses on the fluoroscopic anatomy, pelvic cavity, and complications. In addition, a file for 3-dimensional printing is provided. Profound understanding of this region is fundamental to facilitate safe procedures and to avoid unnecessary complications.

  Dec. 2024, JACC. Case reports, 29(23) (23), 102800 - 102800, English, International magazine

  Scientific journal


• Deep-learning-driven optical coherence tomography analysis for cardiovascular outcome prediction in patients with acute coronary syndrome.

  Tomoyo Hamana, Makoto Nishimori, Satoki Shibata, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Shunsuke Kakizaki, Satoru Sasaki, Hiroyuki Fujii, Yuto Osumi, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Yuta Fukuishi, Koshi Matsuhama, Hiroshi Tsunamoto, Hiroya Okamoto, Kotaro Higuchi, Tatsuya Kitagawa, Masakazu Shinohara, Koji Kuroda, Masamichi Iwasaki, Amane Kozuki, Junya Shite, Tomofumi Takaya, Ken-Ichi Hirata, Hiromasa Otake

  AIMS: Optical coherence tomography (OCT) can identify high-risk plaques indicative of worsening prognosis in patients with acute coronary syndrome (ACS). However, manual OCT analysis has several limitations. In this study, we aim to construct a deep-learning model capable of automatically predicting ACS prognosis from patient OCT images following percutaneous coronary intervention (PCI). METHODS AND RESULTS: Post-PCI OCT images from 418 patients with ACS were input into a deep-learning model comprising a convolutional neural network (CNN) and transformer. The primary endpoint was target vessel failure (TVF). Model performances were evaluated using Harrell's C-index and compared against conventional models based on human observation of quantitative (minimum lumen area, minimum stent area, average reference lumen area, stent expansion ratio, and lesion length) and qualitative (irregular protrusion, stent thrombus, malapposition, major stent edge dissection, and thin-cap fibroatheroma) factors. GradCAM activation maps were created after extracting attention layers by using the transformer architecture. A total of 60 patients experienced TVF during follow-up (median 961 days). The C-index for predicting TVF was 0.796 in the deep-learning model, which was significantly higher than that of the conventional model comprising only quantitative factors (C-index: 0.640) and comparable to that of the conventional model, including both quantitative and qualitative factors (C-index: 0.789). GradCAM heat maps revealed high activation corresponding to well-known high-risk OCT features. CONCLUSION: The CNN and transformer-based deep-learning model enabled fully automatic prognostic prediction in patients with ACS, with a predictive ability comparable to a conventional survival model using manual human analysis. CLINICAL TRIAL REGISTRATION: The study was registered in the University Hospital Medical Information Network Clinical Trial Registry (UMIN000049237).

  Nov. 2024, European heart journal. Digital health, 5(6) (6), 692 - 701, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Enhanced Plaque Stabilization Effects of Alirocumab - Insights From Artificial Intelligence-Aided Optical Coherence Tomography Analysis of the Alirocumab for Thin-Cap Fibroatheroma in Patients With Coronary Artery Disease Estimated by Optical Coherence Tomography (ALTAIR) Study.

  Tetsuya Yamamoto, Yoichiro Sugizaki, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Satoru Sasaki, Hiroyuki Fujii, Tomoyo Hamana, Yuto Osumi, Seigo Iwane, Hiroshi Tsunamoto, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Hiroya Okamoto, Kotaro Higuchi, Shengxian Tu, Ken-Ichi Hirata, Hiromasa Otake

  BACKGROUND: Proprotein convertase subtilisin/kexin type 9 inhibitors stabilize vulnerable plaque, reducing cardiovascular events. However, manual optical coherence tomography (OCT) analysis of drug efficacy is challenging because of signal attenuation within lipid plaques. METHODS AND RESULTS: Twenty-four patients with thin-cap fibroatheroma were prospectively enrolled and randomized to receive alirocumab (75 mg every 2 weeks) plus rosuvastatin (10 mg/day) or rosuvastatin (10 mg/day) alone. OCT images at baseline and 36 weeks were analyzed manually and with artificial intelligence (AI)-aided software. AI-aided OCT analysis showed significantly greater percentage changes in the alirocumab+rosuvastatin vs. rosuvastatin-alone group in fibrous cap thickness (FCT; median [interquartile range] 212.3% [140.5-253.5%] vs. 88.6% [63.0-119.6%]; P=0.006) and lipid volume (median [interquartile range] -30.8% [-51.8%, -16.6%] vs. -2.1% [-21.6%, 4.3%]; P=0.015). Interobserver reproducibility for changes in minimum FCT and lipid index was relatively low for manual analysis (interobserver intraclass correlation coefficient [ICC] 0.780 and 0.499, respectively), but high for AI-aided analysis (interobserver ICC 0.999 and 1.000, respectively). Agreements between manual and AI-aided OCT analyses of FCT and the lipid index were acceptable (concordance correlation coefficients 0.859 and 0.833, respectively). CONCLUSIONS: AI-aided OCT analysis objectively showed greater plaque stabilization of adding alirocumab to rosuvastatin. Our results highlight the benefits of a fully automated AI-assisted approach for assessing drug efficacy, offering greater objectivity in evaluating serial changes in plaque stability vs. conventional OCT assessment.

  Oct. 2024, Circulation journal : official journal of the Japanese Circulation Society, 88(11) (11), 1809 - 1818, English, Domestic magazine

  Scientific journal


• Impact of morphofunctional assessment with quantitative flow ratio and optical coherence tomography in patients with acute coronary syndromes.

  Yuto Osumi, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Daichi Fujimoto, Shunsuke Kakizaki, Koichi Nakamura, Tomoyo Hamana, Hiroyuki Fujii, Satoru Sasaki, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Amane Kozuki, Junya Shite, Tomofumi Takaya, Akihiko Ishida, Masamichi Iwasaki, Ken-Ichi Hirata, Hiromasa Otake

  BACKGROUND: Combining morphological and physiological evaluations might improve the risk stratification of patients who undergo percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) culprit lesions. AIMS: We aimed to investigate the clinical utility of morphofunctional evaluation after PCI for identifying ACS patients with increased risk of subsequent clinical events. METHODS: We retrospectively studied 298 consecutive ACS patients who had undergone optical coherence tomography (OCT)-guided PCI. We performed OCT-based morphological analysis and quantitative flow ratio (QFR)-based physiological assessment immediately after PCI. The non-culprit segment (NCS) was defined as the most stenotic untreated segment in the culprit vessel. The primary outcome was target vessel failure (TVF), a composite of cardiac death, target vessel-related myocardial infarction, and ischaemia-driven target vessel revascularisation. RESULTS: During a median follow-up period of 990 days, 42 patients experienced TVF. Cox regression analysis revealed that the presence of thin-cap fibroatheroma (TCFA) in the NCS and a low post-PCI QFR, or the presence of TCFA in the NCS and a high ΔQFR in the NCS (QFRNCS), were independently associated with TVF. The subgroup with TCFA in the NCS and a low post-PCI QFR had a significantly higher incidence of TVF (75%) than the other subgroups, and those with TCFA in the NCS and a high ΔQFRNCS had a significantly higher incidence of TVF (86%) than the other subgroups. The integration of TCFA in NCS, post-PCI QFR, and ΔQFRNCS with traditional risk factors significantly enhanced the identification of subsequent TVF cases. CONCLUSIONS: Combining post-PCI OCT and QFR evaluation may enhance risk stratification for ACS patients after successful PCI, particularly in predicting subsequent TVF.

  Aug. 2024, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 20(15) (15), e927-e936, English, International magazine

  Scientific journal


• Diagnostic Accuracy of Pre-Transcatheter Aortic Valve Replacement Nitroglycerin-Free Fractional Flow Reserve-Computed Tomography-Based Physiological Assessment in Patients With Severe Aortic Stenosis for Predicting Post-Transcatheter Aortic Valve Replacement Ischemia.

  Satoru Sasaki, Hiroyuki Kawamori, Takayoshi Toba, Ryo Takeshige, Yusuke Fukuyama, Takashi Hiromasa, Hiroyuki Fujii, Tomoyo Hamana, Yuto Osumi, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Toshiro Shinke, Ken-Ichi Hirata, Hiromasa Otake

  BACKGROUND: Fractional flow reserve-computed tomography (FFRCT) has not been validated in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) for coronary artery disease due to theoretical difficulties in using nitroglycerin for such patients.Methods and Results: In this single-center study, we prospectively enrolled 21 patients (34 vessels) and performed pre-TAVR FFRCTwithout nitroglycerin, pre-TAVR invasive instantaneous wave-free ratio (iFR) measurements, and post-TAVR FFR measurements using a pressure wire. The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of pre-TAVR FFRCT≤0.80 to predict post-TAVR invasive FFR ≤0.80 were 82%, 83%, 82%, 71%, and 90%, respectively. A receiver operating characteristic analysis demonstrated an optimal cutoff of 0.78 for pre-TAVR FFRCTto indicate post-TAVR FFR ≤0.80, with an area under the curve (AUC) of 0.84, and the counterpart cutoff of pre-TAVR iFR was 0.89 with an AUC of 0.86. CONCLUSIONS: FFRCTwithout nitroglycerin could be a useful non-invasive imaging modality for assessing the severity of coronary artery lesions in patients with severe AS.

  Mar. 2024, Circulation journal : official journal of the Japanese Circulation Society, 88(4) (4), 501 - 509, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Diagnostic accuracy of Murray law-based quantitative flow ratio in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement.

  Fukuishi Yuta, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Satoru Sasaki, Tomoyo Hamana, Hiroyuki Fujii, Yuto Osumi, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Ken-Ichi Hirata, Hiromasa Otake

  BACKGROUND: Murray law-based quantitative flow ratio (μQFR) is a novel computational method that enables accurate estimation of fractional flow reserve (FFR) using a single angiographic projection. However, its diagnostic value in patients with severe aortic stenosis (AS) remains unclear. METHOD: We included 25 consecutive patients who underwent transcatheter aortic valve replacement (TAVR) for severe AS with intermediate or greater (30-90%) coronary artery disease (CAD). Pre- and post-TAVR μQFR, QFR, instantaneous flow reserve (iFR), and post-TAVR invasive FFR values were measured. We evaluated the diagnostic performance of pre-TAVR μQFR, QFR, and iFR using post-TAVR FFR ≤ 0.80 as a reference standard of ischemia. RESULT: Pre-TAVR μQFR was significantly correlated with post-TAVR FFR (r = 0.73, p < 0.0001). The area under the curve of pre-TAVR μQFR on post-TAVR FFR ≤ 0.8 was 0.91 (95% confidence interval [CI] 0.77-0.98), comparable to that of pre-TAVR iFR (0.86 [95% CI 0.71-0.98], p = 0.97). The accuracy, sensitivity, specificity, and positive and negative predictive values of pre-TAVR μQFR on post-TAVR FFR ≤ 0.8 were 84.2% (95% CI 68.7-93.4), 61.6% (95% CI 31.6-86.1), 96.0% (95% CI 79.6-99.9), 88.9% (95% CI 52.9-98.3), and 82.8% (95% CI 70.6-90.6), respectively. For pre-TAVR iFR, these values were 76.5% (95% CI 58.8-89.3), 90.9% (95% CI 58.7-99.8), 69.6% (95% CI 47.1-86.8), 58.8% (95% CI 42.8-73.1), and 94.1% (95% CI 70.8-99.1), respectively. CONCLUSION: μQFR could be useful for the physiological evaluation of patients with severe AS with concomitant CAD.

  Mar. 2024, Heart and vessels, English, Domestic magazine

  Scientific journal


• Impact of Pericoronary Adipose Tissue Attenuation on Periprocedural Myocardial Injury in Patients With Chronic Coronary Syndrome.

  Tetsuya Yamamoto, Hiroyuki Kawamori, Takayoshi Toba, Satoru Sasaki, Hiroyuki Fujii, Tomoyo Hamana, Yuto Osumi, Seigo Iwane, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Ken-Ichi Hirata, Hiromasa Otake

  BACKGROUND: Perivascular inflammation contributes to the development of atherosclerosis and microcirculatory dysfunction. Pericoronary adipose tissue (PCAT) attenuation, measured by coronary computed tomography angiography, is a potential indicator of coronary inflammation. However, the relationship between PCAT attenuation, microcirculatory dysfunction, and periprocedural myocardial injury (PMI) remains unclear. METHODS AND RESULTS: Patients with chronic coronary syndrome who underwent coronary computed tomography angiography before percutaneous coronary intervention were retrospectively identified. PCAT attenuation and adverse plaque characteristics were assessed using coronary computed tomography angiography. The extent of microcirculatory dysfunction was evaluated using the angio-based index of microcirculatory resistance before and after percutaneous coronary intervention. Overall, 125 consecutive patients were included, with 50 experiencing PMI (PMI group) and 75 without PMI (non-PMI group). Multivariable analysis showed that older age, higher angio-based index of microcirculatory resistance, presence of adverse plaque characteristics, and higher lesion-based PCAT attenuation were independently associated with PMI occurrence (odds ratio [OR], 1.07 [95% CI, 1.01-1.13]; P=0.02; OR, 1.06 [95% CI, 1.00-1.12]; P=0.04; OR, 6.62 [95% CI, 2.13-20.6]; P=0.001; and OR, 2.89 [95% CI, 1.63-5.11]; P<0.001, respectively). High PCAT attenuation was correlated with microcirculatory dysfunction before and after percutaneous coronary intervention and its exacerbation during percutaneous coronary intervention. Adding lesion-based PCAT attenuation to the presence of adverse plaque characteristics improved the discriminatory and reclassification ability in predicting PMI. CONCLUSIONS: Adding PCAT attenuation at the culprit lesion level to coronary computed tomography angiography-derived adverse plaque characteristics may provide incremental benefit in identifying patients at risk of PMI. Our results highlight the importance of microcirculatory dysfunction in PMI development, particularly in the presence of lesions with high PCAT attenuation. REGISTRATION: URL: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000057722; Unique identifier: UMIN000050662.

  Feb. 2024, Journal of the American Heart Association, 13(3) (3), e031209, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Association of acute improvement in left ventricular longitudinal function after transcatheter aortic valve implantation with outcomes for severe aortic stenosis and preserved ejection fraction.

  Kimikazu Takeuchi, Yuki Yamauchi, Hiroaki Shiraki, Keiko Sumimoto, Ayu Shono, Makiko Suzuki, Kentaro Yamashita, Takayoshi Toba, Hiroyuki Kawamori, Hiromasa Otake, Ken-Ichi Hirata, Hidekazu Tanaka

  BACKGROUND: Global longitudinal strain (GLS) is reportedly a sensitive marker for early subtle abnormalities in left ventricular (LV) performance of asymptomatic patients with severe aortic stenosis (AS) and preserved LV ejection fraction (LVEF). For symptomatic patients with severe AS and preserved LVEF, however, the association of immediate improvement in GLS after transcatheter aortic valve implantation (TAVI) with long-term outcomes remains uncertain. METHODS: This study concerned 151 symptomatic patients with severe AS and preserved LVEF who had undergone TAVI. Echocardiography was performed before TAVI and 7 (7-9) days after TAVI. GLS was determined by means of a two-dimensional speckle-tracking strain using current guidelines. The primary endpoint was defined as a composite endpoint comprising cardiovascular death or re-hospitalization for HF after TAVI over a median follow-up period of 27.7 (11.9-51.4) months. RESULTS: Mean LVEF and GLS were 65 ± 7 % and 12.8 ± 3.4 %, respectively. The Kaplan-Meier curve indicated that patients with acute improvement in GLS after TAVI experienced fewer cardiovascular events than those without such improvement (log-rank P = 0.02). Multivariate analysis showed that non-acute improvement in GLS after TAVI was independently associated with worse outcomes as well as deterioration of the mean transaortic pressure gradient. CONCLUSION: Assessment of GLS immediately after TAVI is a valuable additional parameter for better management of symptomatic patients with severe AS and preserved LVEF who are scheduled for TAVI.

  Oct. 2023, Journal of cardiology, 82(4) (4), 234 - 239, English, International magazine

  Scientific journal


• Clinical impact of optical coherence tomography findings after drug-coated balloon treatment for patients with acute coronary syndromes.

  Tetsuya Yamamoto, Hiroyuki Kawamori, Takayoshi Toba, Shunsuke Kakizaki, Koichi Nakamura, Daichi Fujimoto, Satoru Sasaki, Hiroyuki Fujii, Tomoyo Hamana, Yuto Osumi, Seigo Iwane, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Amane Kozuki, Junya Shite, Masamichi Iwasaki, Akihiko Ishida, Ken-Ichi Hirata, Hiromasa Otake

  BACKGROUND: Drug-coated balloon (DCB) became a potential treatment option for patients with acute coronary syndrome (ACS); however, factors associated with target lesion failure (TLF) remain uncertain. METHODS: This retrospective, multicentre, observational study included consecutive ACS patients who underwent optical coherence tomography (OCT)-guided DCB treatment. Patients were divided into two groups according to the occurrence of TLF, a composite of cardiac death, target vessel-related myocardial infarction, and ischemia-driven target lesion revascularisation. RESULTS: We enrolled 127 patients in this study. During the median follow-up period of 562 (IQR: 342-1164) days, 24 patients (18.9%) experienced TLF, and 103 patients (81.1%) did not. The cumulative 3-year incidence of TLF was 22.0%. The cumulative 3-year incidence of TLF was the lowest in patients with plaque erosion (PE) (7.5%), followed by those with rupture (PR) (26.1%) and calcified nodule (CN) (43.5%). Multivariable Cox regression analysis revealed that plaque morphology was independently associated with TLF on pre-PCI (percutaneous coronary intervention) OCT, and residual thrombus burden (TB) was positively associated with TLF on post-PCI OCT. Further stratification by post-PCI TB revealed a comparable incidence of TLF in patients with PR (4.2%) to that of PE if the culprit lesion had a smaller post-PCI TB than the cut-off value (8.4%). TLF incidence was high in patients with CN, regardless of TB size on post-PCI OCT. CONCLUSIONS: Plaque morphology was strongly associated with TLF for ACS patients after DCB treatment. Residual TB post-PCI might be a key determinant for TLF, especially in patients with PR.

  Sep. 2023, International journal of cardiology, 387, 131149 - 131149, English, International magazine

  Scientific journal


• 経カテーテル大動脈弁置換術施行患者における冠動脈造影検査に基づく定量的冠血流比の有効性

  福石 悠太, 川森 裕之, 鳥羽 敬義, 佐々木 諭, 藤井 寛之, 濱名 智世, 大隅 祐人, 岩根 成豪, 山本 哲也, 浪花 祥太, 坂本 優樹, 松濱 考志, 平田 健一, 大竹 寛雅

  (一社)日本心血管インターベンション治療学会, Aug. 2023, 日本心血管インターベンション治療学会抄録集, 31回, MO26 - 1, English


• Sequential approach for the prevention of phrenic nerve injuries during epicardial radiofrequency ablation of ventricular tachycardia.

  Kenichi Tani, Mitsuru Takami, Hiroyuki Kawamori, Takayoshi Toba, Shunsuke Kakizaki, Koji Fukuzawa

  Jul. 2023, HeartRhythm case reports, 9(7) (7), 429 - 433, English, International magazine

  Scientific journal


• Predictors of target lesion revascularisation after drug-eluting stent implantation for calcified nodules: an optical coherence tomography study.

  Tomoyo Hamana, Hiroyuki Kawamori, Takayoshi Toba, Shunsuke Kakizaki, Koichi Nakamura, Daichi Fujimoto, Satoru Sasaki, Hiroyuki Fujii, Yuto Osumi, Tomoo Fujioka, Makoto Nishimori, Amane Kozuki, Junya Shite, Masamichi Iwasaki, Tomofumi Takaya, Ken-Ichi Hirata, Hiromasa Otake

  BACKGROUND: Evidence of prognostic factors for stent failure after drug-eluting stent implantation for calcified nodules (CNs) is limited. AIMS: We aimed to clarify the prognostic risk factors associated with stent failure among patients who underwent drug-eluting stent implantation for CN lesions using optical coherence tomography (OCT). METHODS: This retrospective, multicentre, observational study included 108 consecutive patients with CNs who underwent OCT-guided percutaneous coronary intervention (PCI). To evaluate the quality of CNs, we measured their signal intensity and analysed the degree of signal attenuation. All CN lesions were divided into dark or bright CNs according to the half width of signal attenuation, greater or lower than 332, respectively. RESULTS: During the median follow-up period of 523 days, 25 patients (23.1%) experienced target lesion revascularisation (TLR). The 5-year cumulative incidence of TLR was 32.6%. Multivariable Cox regression analysis revealed that younger age, haemodialysis, eruptive CNs, dark CNs assessed by pre-PCI OCT, disrupted fibrous tissue protrusions, and irregular protrusions assessed by post-PCI OCT were independently associated with TLR. The prevalence of in-stent CNs (IS-CNs) observed at follow-up OCT was significantly higher in the TLR group than in the non-TLR group. CONCLUSIONS: Factors such as younger age, haemodialysis, eruptive CNs, dark CNs, disrupted fibrous tissue, or irregular protrusions were independently related to TLR in patients with CNs. The high prevalence of IS-CNs might indicate that the main cause of stent failure implanted in CN lesions could be the recurrence of CN progression in the stented segment.

  Mar. 2023, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, English, International magazine

  Scientific journal


• Diagnostic Accuracy of Nitroglycerin-free FFRCT-based Physiological Assessment in Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement(タイトル和訳中)

  佐々木 諭, 大竹 寛雅, 川森 裕之, 鳥羽 敬義, 竹重 遼, 福山 裕介, 柿崎 俊介, 中村 公一, 藤本 大地, 藤井 寛之, 濱名 智世, 大隅 祐人, 山本 哲也, 藤岡 知夫, 岩根 成豪, 浪花 祥太, 坂本 優樹, 松濱 考志, 福石 悠太, 新家 俊郎, 平田 健一

  (一社)日本循環器学会, Mar. 2023, 日本循環器学会学術集会抄録集, 87回, PJ094 - 4, English


• Potential relationship between high wall shear stress and plaque rupture causing acute coronary syndrome

  Yusuke Fukuyama, Hiromasa Otake, Fumiyasu Seike, Hiroyuki Kawamori, Takayoshi Toba, Yu Takahashi, Kyohei Sasabe, Keisuke Kimura, Junya Shite, Amane Kozuki, Masamichi Iwasaki, Tomofumi Takaya, Kazunori Yasuda, Osamu Yamaguchi, Ken-ichi Hirata

  Springer Science and Business Media LLC, Jan. 2023, Heart and Vessels, 38(5) (5), 634 - 644

  Scientific journal


• Optical Coherence Tomography Fractional Flow Reserve and Cardiovascular Outcomes in Patients With Acute Coronary Syndrome.

  Shunsuke Kakizaki, Hiromasa Otake, Fumiyasu Seike, Hiroyuki Kawamori, Takayoshi Toba, Shinsuke Nakano, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Daichi Fujimoto, Koichi Nakamura, Hiroyuki Fujii, Amane Kozuki, Junya Shite, Masamichi Iwasaki, Tomofumi Takaya, Osamu Yamaguchi, Ken-Ichi Hirata

  BACKGROUND: Optical coherence tomography-derived fractional flow reserve (OCT-FFR) correlates strongly with wire-based FFR; however, its clinical significance remains uncertain. OBJECTIVES: This study sought to investigate the relationship between post-percutaneous coronary intervention (PCI) OCT-FFR and long-term clinical outcomes in acute coronary syndrome (ACS). METHODS: This retrospective, multicenter, observational cohort study included consecutive patients with ACS who underwent OCT-guided emergency PCI. We analyzed post-PCI OCT images and calculated OCT-FFR to identify independent factors associated with target vessel failure (TVF) after PCI. RESULTS: Among 364 enrolled patients, 54 experienced TVF during a median follow-up of 36 (IQR: 26-48) months. Vessel-level OCT-FFR was significantly lower in the TVF group than in the non-TVF group (0.87 vs 0.94; P < 0.001). In the multivariable Cox regression analysis, low vessel-level OCT-FFR (HR per 0.1 increase: 0.38; 95% CI: 0.29-0.49; P < 0.001) and thin-cap fibroatheroma in the nonculprit lesion were independently associated with TVF. The TVF rate of vessels with both low vessel-level OCT-FFR (<0.90) and thin-cap fibroatheroma in the nonculprit lesion was 8.1 times higher than that of all other vessels (69.3% vs 12.4%; HR: 8.13; 95% CI: 4.33-15.25; log-rank P < 0.001). Furthermore, adding vessel-level OCT-FFR to baseline characteristics and post-PCI OCT findings improved discriminatory and reclassification ability in identifying patients with subsequent TVF. CONCLUSIONS: Vessel-level OCT-FFR was an independent factor associated with TVF after PCI in patients with ACS. Adding the OCT-FFR measurement to post-PCI OCT findings may enable better discrimination of patients with subsequent TVF after PCI for ACS. (Relationship between Intracoronary Optical Coherence Tomography Derived Virtual Fractional Flow Reserve and cardiovascular outcome on Acute coronary syndrome; UMIN000043858).

  Oct. 2022, JACC. Cardiovascular interventions, 15(20) (20), 2035 - 2048, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Efficacy of myocardial washout of 99mTc-MIBI/Tetrofosmin for the evaluation of inflammation in patients with cardiac sarcoidosis: comparison with 18F-fluorodeoxyglucose positron emission tomography findings.

  Masataka Suzuki, Yu Izawa, Hiroshi Fujita, Keisuke Miwa, Yu Takahashi, Hiroyuki Toh, Takayoshi Toba, Sei Fujiwara, Hiromi Hashimura, Atsushi K Kono, Ken-Ichi Hirata

  OBJECTIVE: Both myocardial perfusion scintigraphy and 18F-fluorodeoxyglucose positron emission tomography (FDG PET) are useful for the diagnosis of cardiac sarcoidosis (CS). However, the association between the washout of 99mTc-labeled tracer and FDG PET has not been established. This study aimed to evaluate the association between the washout of 99mTc-labeled tracer and FDG PET findings in patients with CS. METHODS: We retrospectively analyzed 64 patients (65.0 ± 11.2 years, 53% male) with suspected CS who underwent myocardial single-photon emission computed tomography (SPECT) with 99mTc-labeled tracer and FDG PET. The SPECT images were acquired at 15 min (early images) and 3 h (delayed images) after injection and scored visually using a 17-segment model with a 5-point scoring system. The washout score was defined as the difference between the early and delayed total defect scores. FDG positivity was considered as focal or focal on diffuse patterns on visual assessment, and FDG uptake was quantified by measuring the standardized uptake value (SUV) of each of the 17 segments. RESULTS: The washout score was significantly higher for the CS group than for the non-CS group (3.0 [-1.0-5.0] vs. 0.0 [-0.5-1.0], p = 0.010). Receiver operating characteristic analysis showed that a washout score of ≥ 2 had the best accuracy for detecting CS (88% sensitivity and 56% specificity) and FDG positivity (71% sensitivity and 89% specificity). In the segment-based analysis of 833 segments from 49 patients, excluding 15 patients with diffuse FDG uptake, the median SUVs for FDG uptake for the washout scores of ≤ 0, 1, and 2 were 2.3 (1.8-3.6), 4.2 (2.9-7.8), and 8.3 (6.5-9.4), respectively (p < 0.001). CONCLUSIONS: The washout of 99mTc-labeled tracer can be a useful marker for the evaluation of FDG PET findings in patients with CS.

  Jun. 2022, Annals of nuclear medicine, 36(6) (6), 544 - 552, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Real-world clinical outcomes of percutaneous transluminal septal myocardial ablation for patients with drug-refractory hypertrophic obstructive cardiomyopathy: results from a retrospective multicenter registry of non-high-volume centers.

  Koichi Nakamura, Takayoshi Toba, Hiromasa Otake, Shunsuke Kakizaki, Daichi Fujimoto, Yu Takahashi, Yusuke Fukuyama, Hiroyuki Kawamori, Hidekazu Tanaka, Tomofumi Takaya, Masamichi Iwasaki, Amane Kozuki, Hiroya Kawai, Takatoshi Hayashi, Junya Shite, Ken-Ichi Hirata

  Percutaneous transluminal septal myocardial ablation (PTSMA) is a well-established interventional therapy for drug-refractory hypertrophic obstructive cardiomyopathy (HOCM) as an alternative to surgical myectomy. Although guidelines recommend that PTSMA should be performed in institutions with extensive experience, it is not centralized to such high-volume centers in real-world clinical practice. Thus, this study aimed to assess the feasibility of PTSMA in non-high-volume centers. We retrospectively examined patients with HOCM who underwent PTSMA between August 2012 and May 2020 at four institutions that experienced fewer than 20 cases of PTSMA procedures. The primary clinical endpoint was a composite of safety (all-cause death, electrical defibrillation for ventricular tachycardia or fibrillation, cardiac tamponade, permanent pacemaker implantation, and repeated interventions) and efficacy endpoints (repeated interventions [PTSMA or surgical myectomy]). Fifty-eight consecutive patients were enrolled. During the 30-day follow-up, no major clinical adverse events were noted except three patients (5.2%) requiring permanent pacemaker implantation for complete atrioventricular block. The percentage of patients with New York Heart Association functional class 1 or 2 significantly increased from 8.6 to 100% (p < 0.001). In the Cox proportional hazard model, left ventricular outflow tract pressure gradient at rest ≥ 30 mmHg (hazard ratio [HR] 6.56; 95% confidence interval [CI] 1.44-29.90; p = 0.015) and mitral regurgitation grade ≥ 3 (HR 10.75; 95% CI 1.81-63.79; p = 0.009) at the 30-day follow-up were associated with a composite of major clinical adverse events. The current study demonstrated that 58 patients who underwent PTSMA in non-high-volume centers had favorable 30-day clinical outcomes, with a primary composite endpoint rate of 5.2%. A prospective study with a larger sample size and longer follow-up is warranted to verify the safety and efficacy of PTSMA in non-high-volume centers.

  May 2022, Heart and vessels, English, Domestic magazine

  Scientific journal


• Late Iodine Enhancement and Extracellular Volume Fraction in Cardiac Amyloidosis by Computed Tomography.

  Masataka Suzuki, Yu Izawa, Takayoshi Toba, Atsushi K Kono, Ken-Ichi Hirata

  Mar. 2022, Circulation reports, 4(3) (3), 145 - 146, English, Domestic magazine

  Scientific journal


• Diversity and determinants of the sigmoid septum and its impact on morphology of the outflow tract as revealed using cardiac computed tomography.

  Daisuke Tsuda, Shumpei Mori, Yu Izawa, Hiroyuki Toh, Masataka Suzuki, Yu Takahashi, Takayoshi Toba, Sei Fujiwara, Hidekazu Tanaka, Yoshiaki Watanabe, Atsushi K Kono, Ken-Ichi Hirata

  BACKGROUND: The sigmoid septum has been generally evaluated subjectively and qualitatively, without detailed examination of its diversity, impact on the morphology of the left ventricular outflow tract (LVOT), and anatomical background. METHODS: We enrolled 100 patients without any background cardiac diseases (67.5 ± 12.8 years old; 43% women) who underwent cardiac computed tomography. Basal septal morphology was evaluated using antero-superior and medial bulging angles (bidirectional angulation of the basal septum relative to the LVOT). The eccentricity index of the LVOT, area narrowing ratio (LVOT/virtual basal ring area), aortic-to-left ventricular axial angle (angulation of the aortic root relative to the left ventricle), and wedged height (non-coronary aortic sinus to inferior epicardium distance) were also quantified. RESULTS: The antero-superior bulging, medial bulging, aortic-to-left ventricular axial angles, LVOT eccentricity index, area narrowing ratio, and wedged height were 76° ± 17°, 166° ± 27°, 127° ± 9°, 1.8 ± 0.5, 1.0 ± 0.2, and 41.2 ± 9.1 mm, respectively. Both bulging angles were correlated with each other and contributed to the narrowing and deformation of the LVOT. Angulated aortic root was not correlated with either bidirectional septal bulge or LVOT narrowing. Clockwise rotation of the aortic root rotation was an independent predictor of prominent antero-superior septal bulge. Deeper aortic wedging was a common independent predictor of bidirectional septal bulge. CONCLUSIONS: The extent of septal bulge varies in normal hearts. Along with deep aortic wedging, the bidirectional bulge of the basal septum deforms and narrows the LVOT without affecting the virtual basal ring morphology.

  Feb. 2022, Echocardiography (Mount Kisco, N.Y.), 39(2) (2), 248 - 259, English, International magazine

  Scientific journal


• Progression from normal vessel wall to atherosclerotic plaque: lessons from an optical coherence tomography study with follow-up of over 5 years.

  Ryo Takeshige, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-Ichi Yanaka, Hiroyuki Yamamoto, Akira Nagasawa, Hiroyuki Onishi, Yoichiro Sugizaki, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Ken-Ichi Hirata

  The initial process of atherosclerotic development has not been systematically evaluated. This study aimed to observe atherosclerotic progression from normal vessel wall (NVW) to atherosclerotic plaque and examine local factors associated with such progression using > 5-year long-term follow-up data obtained by serial optical coherence tomography (OCT). A total of 49 patients who underwent serial OCT for lesions with NVW over 5 years (average: 6.9 years) were enrolled. NVW was defined as a vessel wall with an OCT-detectable three-layer structure and intimal thickness ≤ 300 μm. Baseline and follow-up OCT images were matched, and OCT cross sections with NVW > 30° were enrolled. Cross sections were diagnosed as "progression" when the NVW in these cross sections was reduced by > 30° at > 5-year follow-up. Atherogenic progression from NVW to atherosclerotic plaque was observed in 40.8% of enrolled cross sections. The incidence of microchannels in an adjacent atherosclerotic plaque within the same cross section (6.7 vs. 3.3%; p = 0.046) and eccentric distribution of atherosclerotic plaque (25.0 vs. 12.6%; p < 0.001) at baseline was significantly higher in cross sections with progression than in those without. Cross sections with progression exhibited significantly higher NVW intimal thickness at baseline than cross sections without progression (200.1 ± 53.7 vs. 180.2 ± 59.6 μm; p < 0.001). Multivariate analysis revealed that the presence of microchannels in an adjacent atherosclerotic plaque, eccentric distribution of atherosclerotic plaque, and greater NVW intimal thickness at baseline were independently associated with progression at follow-up. The presence of microchannels in an adjacent atherosclerotic plaque, eccentric distribution of atherosclerotic plaque, and greater NVW intimal thickness were potentially associated with initial atherosclerotic development from NVW to atherosclerotic plaque.

  Jan. 2022, Heart and vessels, 37(1) (1), 1 - 11, English, Domestic magazine

  Scientific journal


• The impact of computed tomography-derived aortic atheroma volume on prognosis after transcatheter aortic valve replacement.

  Hiroshi Fujita, Takayoshi Toba, Keisuke Miwa, Masataka Suzuki, Yu Takahashi, Hiroyuki Toh, Yu Izawa, Hiroyuki Kawamori, Hiromasa Otake, Sei Fujiwara, Yoshiaki Watanabe, Atsushi Kono, Ken-Ichi Hirata

  BACKGROUND: The impact of the extent of aortic atheroma on patients' prognosis after transcatheter aortic valve replacement (TAVR) has not been completely evaluated. This study aimed to evaluate the prognostic value of the aortic atheroma volume (AAV) derived from computed tomography, and the effect of its differences among the segments of the aorta, in patients undergoing TAVR. METHODS: In total, 143 patients with symptomatic severe aortic stenosis who underwent pre-procedural computed tomography before TAVR procedure indication were evaluated. AAV was calculated by measuring the aortic lumen and vessel volume using every 1-mm axial image and was further divided into thoracic (TAAV) and abdominal segments (AbAAV). RESULTS: During a median follow-up of 651 days, 24 all-cause and 14 cardiac deaths occurred. In the Kaplan-Meier analysis, the high AAV group had significantly higher all-cause and cardiac mortalities than the low AAV group (p = 0.016 and 0.023, respectively). Regarding segmental AAV, all-cause and cardiac mortalities did not have significant differences between the high and low TAAV groups. Moreover, all-cause and cardiac mortalities were significantly higher in the high AbAAV group than in the low AbAAV group (p = 0.0043 and 0.023, respectively). The multivariable analysis showed that only AbAAV was an independent predictor for all-cause mortality (hazard ratio: 1.06, p = 0.046). CONCLUSION: AAV was significantly associated with the mortality after TAVR. The current study suggests the pre-procedural assessment of AAV is valuable in predicting prognosis after TAVR. However, further investigation with a larger sample size is needed to validate our findings.

  Dec. 2021, International journal of cardiology, 344, 60 - 65, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Prognostic Impact of Myocardial Extracellular Volume Fraction Assessment Using Dual-Energy Computed Tomography in Patients Treated With Aortic Valve Replacement for Severe Aortic Stenosis.

  Masataka Suzuki, Takayoshi Toba, Yu Izawa, Hiroshi Fujita, Keisuke Miwa, Yu Takahashi, Hiroyuki Toh, Hiroyuki Kawamori, Hiromasa Otake, Hidekazu Tanaka, Sei Fujiwara, Yoshiaki Watanabe, Atsushi K Kono, Kenji Okada, Ken-Ichi Hirata

  Background Myocardial extracellular volume fraction (ECV), measured by cardiac magnetic resonance imaging, is a useful prognostic marker for patients who have undergone aortic valve replacement (AVR) for aortic stenosis. However, the prognostic significance of ECV measurements based on computed tomography (CT) is unclear. This study evaluated the association between ECV measured with dual-energy CT and clinical outcomes in patients with aortic stenosis who underwent transcatheter or surgical AVR. Methods and Results We retrospectively enrolled 95 consecutive patients (age, 84.0±5.0 years; 75% women) with severe aortic stenosis who underwent preprocedural CT for transcatheter AVR planning. ECV was measured using iodine density images obtained by delayed enhancement dual-energy CT. The primary end point was a composite outcome of all-cause death and hospitalization for heart failure after AVR. The mean ECV measured with CT was 28.1±3.8%. During a median follow-up of 2.6 years, 22 composite outcomes were observed, including 15 all-cause deaths and 11 hospitalizations for heart failure. In Kaplan-Meier analysis, the high ECV group (≥27.8% [median value]) had significantly higher rates of composite outcomes than the low ECV group (<27.8%) (log-rank test, P=0.012). ECV was the only independent predictor of adverse outcomes on multivariable Cox regression analysis (hazards ratio, 1.25; 95% CI, 1.10‒1.41; P<0.001). Conclusions Myocardial ECV measured with dual-energy CT in patients who underwent aortic valve intervention was an independent predictor of adverse outcomes after AVR.

  Sep. 2021, Journal of the American Heart Association, 10(18) (18), e020655, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Association Between Visit-to-Visit Variability in Low-Density Lipoprotein Cholesterol and Plaque Rupture That Leads to Acute Coronary Syndrome.

  Shinsuke Nakano, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yoichiro Sugizaki, Akira Nagasawa, Ryo Takeshige, Yoichiro Matsuoka, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Junya Shite, Amane Kozuki, Masamichi Iwasaki, Koji Kuroda, Tomofumi Takaya, Ken-Ichi Hirata

  Background: The effect of intraindividual variability in lipid levels on the onset of acute coronary syndrome (ACS) remains uncertain. We evaluated the relationship between intraindividual variability in lipid levels and culprit lesion morphologies by optical coherence tomography (OCT). Methods and Results: Seventy-four consecutive patients with ACS whose cholesterol levels were assessed ≥3 times during outpatient visits before the onset of ACS were enrolled in the study; 222 patients without significant stenotic lesions were used as a control group. Based on OCT findings of culprit lesions, ACS patients were categorized into a plaque rupture ACS (PR-ACS) group (n=44) or a non-plaque rupture ACS (NPR-ACS) group (erosion or calcified nodule; n=30). Visit-to-visit variability in lipid levels was evaluated using the corrected variability independent of the mean (cVIM). Patients with ACS had significantly higher low-density lipoprotein cholesterol (LDL-C) levels and cVIM in LDL-C than the control group. The PR-ACS group had significantly higher mean LDL-C levels and greater cVIM in LDL-C than the control group. The PR-ACS group had a significantly higher cVIM than the NPR-ACS group, despite similar mean LDL-C levels. Multivariate analysis revealed that higher cVIM of LDL-C was an independent predictor of PR-ACS (odds ratio 1.06; P=0.018). Conclusions: In addition to the LDL-C level, greater visit-to-visit variability in LDL-C levels may be associated with the onset of ACS induced by plaque rupture.

  Sep. 2021, Circulation reports, 3(9) (9), 540 - 549, English, Domestic magazine

  Scientific journal


• Varied Extent of Mitral Annular Disjunction Among Cases With Different Phenotypes of Mitral Valve Prolapse.

  Hiroyuki Toh, Shumpei Mori, Yu Izawa, Takayoshi Toba, Yoshiaki Watanabe, Atsushi K Kono, Ken-Ichi Hirata

  Detailed 3-dimensional analysis of mitral annular disjunction was undertaken in 3 comparative cases of mitral valve prolapse. A case of Barlow disease showed extensive disjunction, whereas cases of fibroelastic deficiency and forme fruste demonstrated less extensive disjunction. Considering the current controversies surrounding disjunction, these observations call for detailed research in the future. (Level of Difficulty: Advanced.).

  Aug. 2021, JACC. Case reports, 3(10) (10), 1251 - 1257, English, International magazine


• Morphological Plaque Characteristics and Clinical Outcomes in Patients With Acute Coronary Syndrome and a Cancer History.

  Kosuke Tanimura, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Akira Nagasawa, Shinsuke Nakano, Yu Takahashi, Yusuke Fukuyama, Amane Kozuki, Junya Shite, Masamichi Iwasaki, Koji Kuroda, Tomofumi Takaya, Ken-Ichi Hirata

  Background Although patients with a cancer history have a 2 to 3 times higher risk for acute coronary syndrome (ACS), the morphological characteristics of ACS culprit plaque in those patients and their relations with clinical outcomes remain unknown. Methods and Results This retrospective, multicenter, observational cohort study included consecutive patients with ACS who underwent optical coherence tomography-guided emergent percutaneous coronary intervention. Patients were categorized into those without a cancer history, those with a cancer history, and those currently receiving cancer treatment. ACS culprit lesions were classified as plaque rupture, plaque erosion, or calcified nodule using optical coherence tomography. Plaque erosion frequency was significantly higher in culprit lesions of patients with current cancer and patients with cancer history than in those of patients without cancer history (56.3% versus 61.7% versus 36.5%). Calcified nodule incidence was significantly higher in patients without cancer history than in patients with current cancer and patients without cancer history (patients with current cancer: 12.4% versus patients without cancer history: 25.5% versus patients without cancer history: 12.6%, P<0.001). Cancer history was independently associated with nonplaque rupture (plaque erosion or calcified nodule) in ACS culprit lesions (odds ratio, 4.00; P<0.001). Cancer history was independently associated with major adverse cardiovascular events (hazard ratio [HR], 1.98; P=0.002). Nonplaque rupture in ACS culprit lesions was independently associated with major adverse cardiovascular events (HR, 1.60; P=0.011). Conclusions Patients with a cancer history had significantly worse clinical outcomes after ACS than those without a cancer history. Those with a cancer history had significantly higher plaque erosion and calcified nodule incidences in the ACS culprit lesions, which might partly explain their worse clinical outcomes. Registration URL: www.umin.ac.jp/ctr/index.htm. Unique Identifier: UMIN000038442.

  Aug. 2021, Journal of the American Heart Association, 10(15) (15), e020243, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Revival of Mitral and Tricuspid Annular Disjunctions: Are These Really Abnormal Findings?

  Hiroyuki Toh, Shumpei Mori, Yu Izawa, Takayoshi Toba, Tatsuya Nishii, Ken-Ichi Hirata

  Aug. 2021, JACC. Cardiovascular imaging, 14(8) (8), 1682 - 1684, English, International magazine


• Normative Aortic Valvar Measurements in Adults Using Cardiac Computed Tomography - A Potential Guide to Further Sophisticate Aortic Valve-Sparing Surgery.

  Yu Izawa, Shumpei Mori, Justin T Tretter, James A Quintessenza, Hiroyuki Toh, Takayoshi Toba, Yoshiaki Watanabe, Atsushi K Kono, Kenji Okada, Ken-Ichi Hirata

  BACKGROUND: A thorough understanding of the anatomy of the aortic valve is necessary for aortic valve-sparing surgery. Normal valvar dimensions and their relationships in the living heart, however, have yet to be fully investigated in a 3-dimensional fashion.Methods and Results:In total, 123 consecutive patients (66±12 years, Men 63%) who underwent coronary computed tomographic angiography were enrolled. Mid-diastolic morphology of the aortic roots, including height of the interleaflet triangles, geometric height, free margin length of each leaflet, effective height, and coaptation length were measured using multiplanar reconstruction images. Average height of the interleaflet triangle, geometric height, free margin length, effective height, and the coaptation length were 17.3±1.8, 14.7±1.3, 32.6±3.6, 8.6±1.4, and 3.2±0.8 mm, respectively. The right coronary aortic leaflet displayed the longest free margin length and shortest geometric height. Geometric height, free margin length, and effective height showed positive correlations with aortic root dimensions. Coaptation length, however, remained constant regardless of aortic root dimensions. CONCLUSIONS: Diversities, as well as characteristic relationships among each value involving the aortic root, were identified using living-heart datasets. The aortic leaflets demonstrated compensatory elongation along with aortic root dilatation to maintain constant coaptation length. These measurements will serve as the standard value for revealing the underlying mechanism of aortic regurgitation to plan optimal aortic valve-sparing surgery.

  Jun. 2021, Circulation journal : official journal of the Japanese Circulation Society, 85(7) (7), 1059 - 1067, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Successful percutaneous balloon aortic valvuloplasty for worsening paravalvular leakage detected one week after the balloon expandable transcatheter aortic valve replacement.

  Takayoshi Toba, Hiroyuki Kawamori, Hiromasa Otake, Ken-Ichi Hirata

  Jun. 2021, Cardiovascular intervention and therapeutics, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Relationship among clinical characteristics, morphological culprit plaque features, and long-term prognosis in patients with acute coronary syndrome.

  Akira Nagasawa, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yoichiro Sugizaki, Ryo Takeshige, Shinsuke Nakano, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Amane Kozuki, Junya Shite, Masamichi Iwasaki, Koji Kuroda, Tomofumi Takaya, Ken-Ichi Hirata

  Culprit lesions of acute coronary syndrome (ACS) could be classified as plaque rupture (PR), erosion, or calcified nodule (CN). We aimed to determine the relationship among clinical characteristics, morphological plaque features, and long-term prognosis in ACS. Patients with ACS, who underwent pre-intervention optical coherence tomography between April 2013 and July 2018 were retrospectively enrolled, and classified into the three groups based on the culprit lesion morphology. In the 436 patients enrolled, incidences of PR, erosion, and CN in ACS culprit lesions were 46.1, 39.9, and 14.0%, respectively. Plaque erosion was more frequent in men aged < 60 years and CN was more frequent in older adults in both sexes (≥ 80 years) (P < 0.001). Patients with CN had a higher incidence of hemodialysis treatment (P < 0.001) and diabetes (P = 0.003). Multivariate analysis revealed that ST elevation myocardial infarction (STEMI) (P = 0.049) and presence of thin-cap fibroatheroma (TCFA) at the culprit lesion were independently associated with PR; in younger patients (< 60 year), preserved left ventricular ejection fraction and lower incidence of TCFA were correlated with plaque erosion; and older age, non-STEMI, or unstable angina pectoris, higher serum brain natriuretic peptide levels, and lower incidence of TCFA were independently associated with CN. Multivariable analysis revealed that CN (odds ratio [OR] 1.990, P = 0.005), male sex (OR 2.012, P = 0.004), and older age (OR 1.036, P < 0.001) were independently associated with future adverse events during a median follow-up of 757 days. Different patient characteristics and morphological features were associated with the type of culprit lesion in patients with ACS.

  May 2021, The international journal of cardiovascular imaging, English, International magazine

  Scientific journal


• Prevalence and extent of mitral annular disjunction in structurally normal hearts: comprehensive 3D analysis using cardiac computed tomography.

  Hiroyuki Toh, Shumpei Mori, Yu Izawa, Hiroshi Fujita, Keisuke Miwa, Masataka Suzuki, Yu Takahashi, Takayoshi Toba, Yoshiaki Watanabe, Atsushi K Kono, Justin T Tretter, Ken-Ichi Hirata

  AIMS: Mitral annular disjunction is fibrous separation between the attachment of the posterior mitral leaflet and the basal left ventricular myocardium initially described in dissected hearts. Currently, it is commonly evaluated by echocardiography, and potential relationships with mitral valve prolapse and ventricular arrhythmia have been suggested. However, controversy remains as its prevalence and extent have not been fully elucidated in normal living subjects. METHODS AND RESULTS: Systolic datasets of cardiac computed tomography obtained from 98 patients (mean age, 69.1 ± 12.6 years; 81% men) with structurally normal hearts were assessed retrospectively. Circumferential extent of both mitral leaflets and disjunction was determined by rotating orthogonal multiplanar reconstruction images around the central axis of the mitral valvar orifice. Distribution angle within the circumference of the mitral valvar attachment and maximal height of disjunction were quantified. In total, 96.0% of patients demonstrated disjunction. Average distribution angles of the anterior and posterior mitral leaflets were 91.3 ± 9.4° and 269.8 ± 9.7°, respectively. Average distribution angle of the disjunction was 105.1 ± 49.2°, corresponding to 39.0 ± 18.2% of the entire posterior mitral valvar attachment. Median value of the maximal height of disjunction was 3.0 (1.5-7.0) mm. Distribution prevalence map of the disjunction revealed characteristic double peaks, with frequent sites of the disjunction located at the anterior to antero-lateral and inferior to infero-septal regions. CONCLUSION: Mitral annular disjunction is a rather common finding in the normal adult heart with bimodal distribution predominantly observed involving the P1 and P3 scallops of the posterior mitral leaflet.

  May 2021, European heart journal. Cardiovascular Imaging, 22(6) (6), 614 - 622, English, International magazine

  Scientific journal


• Prediction of the debulking effect of rotational atherectomy using optical frequency domain imaging.

  Kosuke Tanimura, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Akira Nagasawa, Yoichiro Sugizaki, Ryo Takeshige, Shinsuke Nakano, Yoichiro Matsuoka, Yu Takahashi, Yusuke Fukuyama, Ken-Ichi Hirata

  Whether predicting the rotational atherectomy (RA) effect based on the position of optical frequency domain imaging (OFDI) is accurate remains uncertain. The aim of this study was to evaluate the predictive accuracy of OFDI in identifying RA location and area. Twenty-five patients who underwent RA with OFDI were included. On pre-RA OFDI images, a circle with the dimension of a Rota burr was drawn at the center of the OFDI catheter. The area where the circle overlapped with the vessel wall was defined as the predicted ablation area (P-area), and the actual ablated area (A-area) was measured. The predictive accuracy of OFDI was evaluated as follows: overlapped ablation area (O-area: overlapping P- and A-areas) divided by P-area = %Correct-area, and A-area - O-area divided by A-area = %Error-area. Cross-sections were separated into four categories based on the median values of %Correct- and %Error-area. Among 334 cross-sections, RA effects were confirmed in the predicted location in 87% of them. The median %Correct- and %Error-areas were 43.1% and 64.2%, respectively. Floppy wire, narrow lumen area, OFDI catheter close to the intima, and large arc of calcium were independently associated with good prediction (high %Correct-/low %Error-areas). Non-left anterior descending lesions, OFDI catheter far from the wire, and OFDI catheter and wire far from the intima were associated with irrelevant ablation (low %Correct-/ high %Error-areas). The accuracy of the OFDI-based predictions for RA effects was acceptable with regard to location, but not high with regard to area. Wire types, target vessels, and OFDI catheter and wire positions are important determinants for accurately predicting RA effect using pre-procedural OFDI.

  Apr. 2021, Heart and vessels, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Three-dimensional volumetric measurement of the aortic root compared to standard two-dimensional measurements using cardiac computed tomography

  Masataka Suzuki, Shumpei Mori, Yu Izawa, Shinsuke Shimoyama, Yu Takahashi, Hiroyuki Toh, Daisuke Tsuda, Takayoshi Toba, Sei Fujiwara, Hidekazu Tanaka, Ken-ichi Hirata, Robert H. Anderson, Justin T. Tretter

  John Wiley and Sons Inc, Apr. 2021, Clinical Anatomy, 34(3) (3), 333 - 341, English

  Scientific journal


• PCIのための心筋虚血評価-冠血流予備能の測定に迫る- 心臓CT検査およびFFRCTに対する当院の取り組みについて

  鳥羽 敬義, 大竹 寛雅, 川森 裕之, 伊澤 有, 渡邊 慶明, 河野 淳, 根宜 典行, 平田 健一

  (一社)日本循環器学会, Mar. 2021, 日本循環器学会学術集会抄録集, 85回, CS3 - 4, Japanese


• Characteristic Distribution Pattern of Disjunction on the Circumference of the Mitral Annulus: Comprehensive Analysis Using Cardiac Computed Tomography(和訳中)

  とう 皓之, 森 俊平, 鳥羽 敬義, 伊澤 有, 藤田 紘, 三和 圭介, 高橋 悠, 鈴木 雅貴, 栗本 浩行, 藤原 征, 渡邊 慶明, 河野 淳, 平田 健一

  (一社)日本循環器学会, Mar. 2021, 日本循環器学会学術集会抄録集, 85回, OJ44 - 1, English


• Preoperative frailty affects postoperative complications, exercise capacity, and home discharge rates after surgical and transcatheter aortic valve replacement.

  Kodai Komaki, Naofumi Yoshida, Seimi Satomi-Kobayashi, Yasunori Tsuboi, Masato Ogawa, Kumiko Wakida, Takayoshi Toba, Hiroyuki Kawamori, Hiromasa Otake, Atsushi Omura, Katsuhiro Yamanaka, Takeshi Inoue, Tomoya Yamashita, Yoshitada Sakai, Kazuhiro P Izawa, Kenji Okada, Ken-Ichi Hirata

  Assessment of frailty is important for risk stratification among the elderly with severe aortic stenosis (AS) when considering interventions such as surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). However, evidence of the impact of preoperative frailty on short-term postoperative outcomes or functional recovery is limited. This retrospective study included 234 consecutive patients with severe AS who underwent SAVR or TAVR at Kobe University Hospital between Dec 2013 and Dec 2019. Primary outcomes were postoperative complications, postoperative 6-min walking distance (6MWD), and home discharge rates. The mean age was 82 ± 6.6 years. There were 169 (SAVR: 80, TAVR: 89) and 65 (SAVR: 20, TAVR: 45) patients in the non-frail and frail groups, respectively (p = 0.02). The postoperative complication rates in the frail group were significantly higher than those in the non-frail group [30.8% (SAVR: 35.0%, TAVR: 28.9%) vs. 10.7% (SAVR: 15.0%, TAVR: 6.7%), p < 0.001]. The home discharge rate in the non-frail group was significantly higher than that in the frail group [85.2% (SAVR: 81.2%, TAVR: 88.8%) vs. 49.2% (SAVR: 55.0%, TAVR: 46.7%), p < 0.001]. The postoperative 6MWD in the non-frail group was significantly longer than that in the frail group [299.3 ± 87.8 m (SAVR: 321.9 ± 90.8 m, TAVR: 281.1 ± 81.3 m) vs. 141.9 ± 92.4 m (SAVR: 167.8 ± 92.5 m, TAVR: 131.6 ± 91.3 m), p < 0.001]. The TAVR group did not show a decrease in the 6MWD after intervention, regardless of frailty. We report for the first time that preoperative frailty was strongly associated with postoperative complications, 6MWD, and home discharge rates following both SAVR and TAVR. Preoperative frailty assessment may provide useful indications for planning better individualized therapeutic interventions and supporting comprehensive intensive care before and after interventions.

  Feb. 2021, Heart and vessels, 36(8) (8), 1234 - 1245, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A rare manifestation of primary cardiac intimal sarcoma: mimicking non-bacterial thrombotic endocarditis with severe mitral regurgitation.

  Saki Todo, Takayoshi Toba, Kenji Okada, Ken-Ichi Hirata

  Feb. 2021, European heart journal cardiovascular Imaging, English, International magazine

  Scientific journal


• Efficacy of optical frequency domain imaging in detecting peripheral artery disease: the result of a multi-center, open-label, single-arm study

  Hiroyuki Kawamori, Akihide Konishi, Toshiro Shinke, Hirokuni Akahori, Masaharu Ishihara, Hiroaki Tsujita, Hiromasa Otake, Takayoshi Toba, Shinsuke Nakano, Kosuke Tanimura, Yoshiro Tsukiyama, Isao Nanba, Yasumasa Kakei, Takahiro Yasuda, Takashi Omori, Takashi Kubo, Amane Kozuki, Junya Shite, Ken-ichi Hirata

  Springer Science and Business Media LLC, Jan. 2021, Heart and Vessels

  Scientific journal


• Impact of the Antithrombotic Effects of Prasugrel on Mid-Term Vascular Healing in Acute Coronary Syndrome vs. Stable Coronary Artery Disease

  Takayoshi Toba, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Naoki Matsukawa, Akira Matsuura, Takayuki Ishihara, Daisuke Matsumoto, Nobuaki Igarashi, Takatoshi Hayashi, Yoshinori Yasaka, Makoto Kadotani, Takashi Fujii, Junya Shite, Masaharu Okada, Takashi Sakakibara, Ken-ichi Hirata

  Japanese Circulation Society, Jan. 2021, Circulation Journal

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Complete resolution of severe secondary mitral regurgitation accompanying eosinophilic myocarditis due to immunosuppressive treatment

  Hiroyuki Takahara, Takayoshi Toba, Daichi Fujimoto, Yu Izawa, Kensuke Matsumoto, Hidekazu Tanaka, Ken-ichi Hirata

  Elsevier Ltd, 2021, Journal of Cardiology Cases, English

  Scientific journal


• Wall Shear Stress and Plaque Vulnerability

  Takayoshi Toba, Hiromasa Otake, Gilwoo Choi, Hyun Jin Kim, Hiroyuki Onishi, Yoichiro Sugizaki, Ryo Takeshige, Akira Nagasawa, Yuichiro Nagano, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Hiroyuki Kawamori, Shumpei Mori, Masahito Kawata, Charles A. Taylor, Ken-ichi Hirata

  Elsevier BV, Jan. 2021, JACC: Cardiovascular Imaging, 14(1) (1), 315 - 317

  Scientific journal


• Impact of daily glucose fluctuations on cardiovascular outcomes after percutaneous coronary intervention for patients with stable coronary artery disease undergoing lipid‐lowering therapy

  Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Masaru Kuroda, Yushi Hirota, Kazuhiko Sakaguchi, Wataru Ogawa, Ken‐ichi Hirata

  Wiley, Dec. 2020, Journal of Diabetes Investigation

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 心臓サルコイドーシスの炎症評価における99mTc製剤のWashout評価の有用性

  鈴木 雅貴, 伊澤 有, 藤田 紘, 三和 圭介, トウ 皓之, 鳥羽 敬義, 渡邊 慶明, 河野 淳, 藤原 征, 平田 健一

  日本心臓核医学会, Dec. 2020, 日本心臓核医学会ニュースレター, 22(2) (2), 54 - 54, Japanese


• Feasibility of morphological assessment of coronary artery calcification with electrocardiography-gated non-contrast computed tomography: a comparative study with optical coherence tomography

  Yu Takahashi, Takayoshi Toba, Hiromasa Otake, Yusuke Fukuyama, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Yu Izawa, Hiroyuki Kawamori, Atsushi K. Kono, Sei Fujiwara, Ken-ichi Hirata

  Springer Science and Business Media LLC, Nov. 2020, The International Journal of Cardiovascular Imaging

  Scientific journal


• Ascending aortic elongation and correlative change in overall configuration of the proximal aorta in elderly patients with severe aortic stenosis

  Takayoshi Toba, Shumpei Mori, Yu Izawa, Hiroyuki Toh, Daisuke Tsuda, Shinsuke Shimoyama, Hiroyuki Kawamori, Hiromasa Otake, Hidekazu Tanaka, Sei Fujiwara, Ken‐ichi Hirata

  Wiley, Nov. 2020, Clinical Anatomy, 33(8) (8), 1240 - 1248

  Scientific journal


• Efficacy of optical frequency-domain imaging in detecting peripheral artery disease: a single-center open-label, single-arm study protocol.

  Hiroyuki Kawamori, Akihide Konishi, Hiromasa Otake, Takayoshi Toba, Shinsuke Nakano, Kosuke Tanimura, Yoshiro Tsukiyama, Isao Nanba, Takashi Omori, Toshiro Shinke, Ken-ichi Hirata

  Intravascular optical coherence tomography is a high-resolution intracoronary imaging modality, providing a microscopic image of intravascular features. However, it has lower penetration depth than intravascular ultrasound. Recently, a second-generation optical frequency-domain imaging (OFDI) technique has been developed to provide greater penetration depth and faster pullback speed. However, there is little evidence supporting the efficacy of OFDI in patients with peripheral artery disease (PAD) undergoing endovascular treatment (EVT). We aimed to evaluate the ability of OFDI to visualize vessel walls from the superficial femoral artery (SFA) to the below-knee (BK) arteries, as well as the coronary arteries. This clinical trial is a single-center, single-arm, open-label study to be conducted in Japan. A total of 20 patients will be enrolled in this study. The primary endpoint is to obtain a clear image of the intravascular features of the SFA and BK arteries, specifically the visualization of ≥ 270° of the vessel lumen in ≥ 16 out of 21 cross sections. Obtaining clear images in ≥ 85% of cases will be regarded as confirmation of the ability of OFDI to visualize vessel walls from the SFA to the BK arteries. This is the first clinical trial to be conducted accordance with good clinical practice to expand the indications of OFDI for PAD patients undergoing EVT in Japan. The result of this study will help provide another imaging option during EVT in daily practice.

  Oct. 2020, Cardiovascular intervention and therapeutics, 35(4) (4), 385 - 391, English, Domestic magazine

  Scientific journal


• Correction to: Efficacy of optical frequency‑domain imaging in detecting peripheral artery disease: a single‑center open‑label, single‑arm study protocol.

  Hiroyuki Kawamori, Akihide Konishi, Hiromasa Otake, Takayoshi Toba, Shinsuke Nakano, Kosuke Tanimura, Yoshiro Tsukiyama, Isao Nanba, Takashi Omori, Toshiro Shinke, Ken-Ichi Hirata

  In the original publication of the article, the author group was published without full names and one of the co-authors' name was published incorrectly. The full names of author group and correct co-authors' name are given in this Correction.

  Oct. 2020, Cardiovascular intervention and therapeutics, 35(4) (4), 392 - 392, English, Domestic magazine

  Scientific journal


• Concomitant Use of Rosuvastatin and Eicosapentaenoic Acid Significantly Prevents Native Coronary Atherosclerotic Progression in Patients With In-Stent Neoatherosclerosis

  Yoichiro Sugizaki, Hiromasa Otake, Koji Kuroda, Hiroyuki Kawamori, Takayoshi Toba, Akira Nagasawa, Ryo Takeshige, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Ken-ichi Hirata

  Japanese Circulation Society, Sep. 2020, Circulation Journal, 84(10) (10), 1826 - 1836

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 左室心尖部の局所的な菲薄化 予期せぬ共通所見とその臨床的意義(Localized Thinning of the Left Ventricular Apex: Unexpectedly Common Findings and Its Clinical Implications)

  山本 恭子, 森 俊平, 鳥羽 敬義, 伊澤 有, 福沢 公二, 河野 淳, 平田 健一

  (一社)日本循環器学会, Jul. 2020, 日本循環器学会学術集会抄録集, 84回, PJ17 - 8, English


• Localized Thinning of the Left Ventricular Apex: Unexpectedly Common Findings and Its Clinical Implications(和訳中)

  山本 恭子, 森 俊平, 鳥羽 敬義, 伊澤 有, 福沢 公二, 河野 淳, 平田 健一

  (一社)日本循環器学会, Jul. 2020, 日本循環器学会学術集会抄録集, 84回, PJ17 - 8, English


• Living Anatomy of the Ventricular Myocardial Crescents Supporting the Coronary Aortic Sinuses

  Hiroyuki Toh, Shumpei Mori, Justin T. Tretter, Yu Izawa, Shinsuke Shimoyama, Masataka Suzuki, Yu Takahashi, Daisuke Tsuda, Takayoshi Toba, Sei Fujiwara, Ken-ichi Hirata, Robert H. Anderson

  W.B. Saunders, Jun. 2020, Seminars in Thoracic and Cardiovascular Surgery, 32(2) (2), 230 - 241, English

  Scientific journal


• Adding Alirocumab to Rosuvastatin Helps Reduce the Vulnerability of Thin-Cap Fibroatheroma

  Yoichiro Sugizaki, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-ichi Yanaka, Hiroyuki Yamamoto, Akira Nagasawa, Hiroyuki Onishi, Ryo Takeshige, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Toshiro Shinke, Tatsuro Ishida, Ken-ichi Hirata

  Elsevier BV, Jun. 2020, JACC: Cardiovascular Imaging, 13(6) (6), 1452 - 1454

  Scientific journal


• Revisiting the prevalence and diversity of localized thinning of the left ventricular apex.

  Kyoko Yamamoto, Shumpei Mori, Koji Fukuzawa, Koji Miyamoto, Takayoshi Toba, Yu Izawa, Hidekazu Tanaka, Atsushi K Kono, Ken-Ichi Hirata

  BACKGROUND: The left ventricular apex commonly has a paper-thin structure. However, available data about its structure are limited to variable samples, methodologies, and results. OBJECTIVE: To investigate the structural anatomy of the left ventricular apex using living heart datasets with the latest computed tomography scanner. METHODS: One hundred thirty-one consecutive patients (median age, 73 years; 58% men) who underwent cardiac computed tomography were retrospectively analyzed. Patients with severe aortic stenosis were analyzed separately. Thickness and diameters of the thinnest part of the left ventricular apex during mid-diastole were measured using orthogonal multiplanar reconstruction images. The area of thinning was estimated using the formula for the ellipse. RESULTS: In 88 patients without severe aortic stenosis, the median thickness of the thinnest area of the left ventricular apex was only 0.9 mm. Among them, 74%, 99%, and 100% of cases displayed a left ventricular apex thinner than 1.0, 3.0, and 5.0 mm, respectively. The median area of the thinnest region was 5.6 mm2 . In 43 patients with severe aortic stenosis, the median thickness of the thinnest area of the left ventricular apex was 1.2 mm. Among them, 51%, 93%, and 100% of cases displayed a left ventricular apex thinner than 1.0, 3.0, and 5.0 mm, respectively. The median area of the thinnest region was 3.9 mm2 . CONCLUSIONS: Localized thinning of the left ventricular apex is unexceptional, regardless of aortic stenosis with concentric left ventricular hypertrophy, thus highlighting the need for a reappreciation of this feature to avoid inadvertent catastrophic complications.

  Feb. 2020, Journal of cardiovascular electrophysiology, 31(4) (4), 915 - 920, English, International magazine

  [Refereed]

  Scientific journal


• Effect of rosuvastatin and eicosapentaenoic acid on neoatherosclerosis: the LINK-IT Trial.

  Koji Kuroda, Hiromasa Otake, Masakazu Shinohara, Masaru Kuroda, Shigeyasu Tsuda, Takayoshi Toba, Yuichiro Nagano, Ryuji Toh, Tatsuro Ishida, Toshiro Shinke, Ken-Ichi Hirata

  AIMS: We aimed to assess the effect of 10 mg/day of rosuvastatin plus eicosapentaenoic acid (EPA) versus 2.5 mg/day of rosuvastatin on the extent of neoatherosclerosis using optical coherence tomography (OCT). METHODS AND RESULTS: We randomly assigned 50 patients with non-obstructive neoatherosclerotic plaques detected on OCT to receive either rosuvastatin 10 mg/day and EPA 1,800 mg/day (intensive therapy group) or rosuvastatin 2.5 mg (standard therapy group). Follow-up OCT was performed one year later to evaluate serial changes in neoatherosclerosis. The serum low-density lipoprotein cholesterol (LDL-C) level decreased significantly from baseline to 12-month follow-up in the intensive therapy group (89 mg/dL to 70 mg/dL; p<0.001), while no change occurred in the standard therapy group. Lipid index change and percent changes in macrophage grade were significantly lower in the intensive therapy group than in the standard therapy group (-53.6 vs 310.1, p=0.001; -37.0% vs 35.3%, p<0.001; respectively). Percent changes in lipid index and macrophage grade were positively correlated with the changes in serum LDL-C and C-reactive protein levels, and negatively correlated with the change in serum EPA/arachidonic acid and 18-hydroxyeicosapentaenoic acid (EPA bioactive metabolite) level. CONCLUSIONS: Compared with rosuvastatin 2.5 mg/day, rosuvastatin 10 mg/day and EPA 1,800 mg/day significantly stabilised non-obstructive neoatherosclerotic plaques. CLINICAL TRIAL REGISTRATION: UMIN ID: UMIN000012576. https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000014711.

  Dec. 2019, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 15(12) (12), e1099-e1106, English, International magazine

  Scientific journal


• Localized basal left ventricular dyssynchrony induced by manifest accessory pathway: Successful differentiation from cardiac involvement of sarcoidosis with administration of flecainide acetate

  Daisuke Tsuda, Shumpei Mori, Shun Yokota, Yu Izawa, Shinsuke Shimoyama, Masataka Suzuki, Yu Takahashi, Hiroyuki Toh, Takayoshi Toba, Hidekazu Tanaka, Sei Fujiwara, Ken-ichi Hirata

  Churchill Livingstone Inc., Nov. 2019, Journal of Electrocardiology, 57, 87 - 89, English

  Scientific journal


• Impaired Cholesterol‐Uptake Capacity of HDL Might Promote Target‐Lesion Revascularization by Inducing Neoatherosclerosis After Stent Implantation

  Yuichiro Nagano, Hiromasa Otake, Takayoshi Toba, Koji Kuroda, Yuto Shinkura, Natsuko Tahara, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Akira Nagasawa, Hiroyuki Onishi, Yoichiro Sugizaki, Ryo Takeshige, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Toshihiko Oshita, Yasuhiro Irino, Hiroyuki Kawamori, Tatsuro Ishida, Ryuji Toh, Toshiro Shinke, Ken‐ichi Hirata

  Ovid Technologies (Wolters Kluwer Health), May 2019, Journal of the American Heart Association, 8(9) (9)

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• JDS-JCSジョイントシンポ(Controversy or Debate)-"Stop DM for Stop CVD"生命予後改善のための糖尿病管理とは ブドウ糖変動が安定冠動脈疾患患者の心血管転帰に与える影響(The Impact of Glucose Fluctuation on Cardiovascular Outcome in Patients with Stable Coronary Artery Disease)

  山本 裕之, 大竹 寛雅, 新家 俊郎, 川森 裕之, 鳥羽 敬義, 永野 雄一朗, 築山 義朗, 谷仲 謙一, 長澤 智, 大西 裕之, 竹重 遼, 杉崎 陽一郎, 中野 槙介, 谷村 幸亮, 松岡 庸一郎, 福山 裕介, 高橋 悠, 廣田 勇士, 坂口 一彦, 平田 健一

  (一社)日本循環器学会, Mar. 2019, 日本循環器学会学術集会抄録集, 83回, SY12 - 2, English


• Effect of Alirocumab and Rosuvastatin or Rosuvastatin Alone on Lipid Core Plaque in Coronary Artery Disease Seen on Near-Infrared Spectroscopy Intravascular Ultrasound (ANTARES)

  Hiromasa Otake, Kosuke Tanimura, Yoichiro Sugizaki, Takayoshi Toba, Hiroyuki Kawamori, Toshiro Shinke, Ken-ichi Hirata

  Japanese Circulation Society, Feb. 2019, Circulation Reports, 1(2) (2), 107 - 111

  Scientific journal


• Impact of dual antiplatelet therapy with adjusted-dose prasugrel on mid-term vascular response in patients undergoing elective percutaneous coronary intervention with everolimus-eluting stents

  Toba T, Shinke T, Otake Hiromasa, Sugizaki Y, Takeshige R, Onishi H, Nagasawa A, Tsukiyama Y, Yanaka K, Nagano Y, Yamamoto H, Kawamori Hiroyuki, Matsuura A, Ishihara T, Matsumoto D, Igarashi N, Hayashi T, Yasaka Y, Kadotani M, Fujii T, Shite J, Okada M, Sakakibara T, Ken-ichi Hirata

  The impact of dual antiplatelet therapy (DAPT) with adjusted-dose (3.75 mg/day) prasugrel for Japanese patients has not been fully investigated in terms of local arterial healing following the elective percutaneous coronary intervention (PCI). The ROUTE-01 elective study was a prospective, 12-center and single-arm registry that enrolled 123 patients who underwent elective PCI with everolimus-eluting stents (EESs) under DAPT with a combination of adjusted-dose prasugrel and aspirin. Serial optical coherence tomography (OCT) was performed at the index PCI and 9-month follow-up to assess the relationship between in-stent thorombus (IST) and residual platelet reactivity measuring platelet reactivity unit (PRU). The patients were classified as extensive, intermediate, and poor metabolizers by cytochrome P450 2C19 (CYP2C19) loss-of-function polymorphisms. The prevalence of IST was 9.0% by 9-month OCT, with no difference amongst the three groups (p = 0.886). The incidences of malapposed and uncovered struts were not different among the groups. PRU was not statistically different among the groups. In multivariate logistic regression analysis, the independent predictor for IST on 9-month OCT was irregular protrusion (odds ratio = 8.952, p = 0.037) on post-PCI OCT, not CYP2C19 loss-of-function polymorphisms. An adequate anti-thrombotic effect with an acceptable incidence of IST was observed irrespective of CYP2C19 loss-of-function polymorphisms. Our data suggests that adjusted-dose prasugrel and aspirin is a feasible treatment option in Japanese patients treated with EESs in elective PCI.

  Jan. 2019, Heart Vessels, 34(6) (6), 936 - 947, English, Domestic magazine

  [Refereed]

  Scientific journal


• Critical exacerbation of idiopathic pulmonary fibrosis after transcatheter aortic valve implantation: Need for multidisciplinary care beyond "heart team".

  Yoichiro Sugizaki, Shumpei Mori, Yuichi Nagamatsu, Tomomi Akita, Akira Nagasawa, Takayoshi Toba, Masatsugu Yamamoto, Tatsuya Nishii, Norihiko Obata, Yoshikatsu Nomura, Hiromasa Otake, Toshiro Shinke, Yutaka Okita, Ken-Ichi Hirata

  An 82-year-old man with severe aortic stenosis and idiopathic pulmonary fibrosis (IPF) underwent transcatheter aortic valve implantation (TAVI) under general anesthesia. However, following a successful TAVI procedure, he developed progressive respiratory failure because of the exacerbation of IPF. Despite the use of immunosuppressants, the patient could not be saved and he died of respiratory failure. Although TAVI is a less invasive procedure compared to conventional surgical aortic valve replacement, it is currently selected for management of severely ill, frail, and elderly patients. This case highlights the potential risk of IPF exacerbation following a TAVI procedure performed under general anesthesia. .

  Nov. 2018, Journal of cardiology cases, 18(5) (5), 171 - 174, English, Domestic magazine


• Comparison of the 9-month intra-stent conditions and 2-year clinical outcomes after Resolute zotarolimus-eluting stent implantation between 3-month and standard dual antiplatelet therapy

  Wataru Fujimoto, Takahiro Sawada, Takayoshi Toba, Yu Takahashi, Taishi Miyata, Shogo Oishi, Tsuyoshi Osue, Tetsuari Onishi, Tomofumi Takaya, Akira Shimane, Yasuyo Taniguchi, Hiroya Kawai, Yoshinori Yasaka

  Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai), Jul. 2018, Journal of Cardiology, 72(1) (1), 66 - 73, English

  [Refereed]

  Scientific journal


• Peri-strut Low-intensity Area Assessed by Mid-term Follow-up Optical Coherence Tomography may Predict Target Lesion Revascularization after Everolimus-Eluting Stent Implantation.

  Kuroda K, Otake Hiromasa, Shinke T, Toba T, Kuroda M, Takahashi H, Terashita D, Uzu K, Kashiwagi D, Nagasawa Y, Nagano Y, Hirata Ken-ichi

  Jun. 2018, EuroIntervention., English

  [Refereed]

  Scientific journal


• Data on impact of monocytes and glucose fluctuation on plaque vulnerability in patients with coronary artery disease.

  Hiroyuki Yamamoto, Naofumi Yoshida, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Kazuhiko Sakaguchi, Yushi Hirota, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Kouji Kuroda, Yoshinori Nagasawa, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-Ichi Yanaka, Takuo Emoto, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa, Ken-Ichi Hirata

  Data presented in this article are supplementary material to our research article entitled "Impact of CD14++CD16+ monocytes on coronary plaque vulnerability assessed by optical coherence tomography in coronary artery disease patients" [1]. This article contains the data of study population, diagnostic ability of CD14++CD16+ monocytes to identify thin-cap fibroatheromas, and association between laboratory variables and plaque properties.

  Jun. 2018, Data in brief, 18, 172 - 175, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Relationship between the membranous septum and the virtual basal ring of the aortic root in candidates for transcatheter implantation of the aortic valve.

  Shumpei Mori, Justin T Tretter, Takayoshi Toba, Yu Izawa, Natsuko Tahara, Tatsuya Nishii, Shinsuke Shimoyama, Hidekazu Tanaka, Toshiro Shinke, Ken-Ichi Hirata, Diane E Spicer, Farhood Saremi, Robert H Anderson

  Knowledge of the anatomy of the membranous septum, as a surrogate to the location of the atrioventricular conduction axis, is a prerequisite for those undertaking transcatheter implantation of the aortic valve (TAVI). Equally important is its relationship of the virtual basal ring. This feature, however, has yet to be adequately described in the living heart. We analyzed computed tomographic angiographic datasets from 107 candidates (84.1 ± 5.2 years, 68% women) for TAVI. Using multiplanar reconstructions, we measured the height and width of the membranous septum, and the distances of its superior and inferior margins from the virtual basal ring plane. We also assessed the extent of wedging of the aortic root between the mitral valve and the ventricular septum. Mean heights and widths of the membranous septum were 6.6 ± 2.0, and 10.2 ± 3.1 mm, respectively, with its size significantly associated with that of the aortic root (P < 0.05). Its superior and inferior margins were 4.5 ± 2.3 and 2.1 ± 2.1 mm, respectively, from the plane of the basal ring. The inferior distance, the surrogate for the adjacency of the atrioventricular conduction axis, was ≤ 5mm in 91% of the patients. Deeper wedging of the aortic root was independently correlated with a shorter inferior distance (β = 0.0569, P = 0.0258). The membranous septum is appreciably closer to the virtual basal ring than previously appreciated. These findings impact on estimations of the risk of damage to the atrioventricular conduction axis during TAVI. Clin. Anat. 31:525-534, 2018. © 2018 Wiley Periodicals, Inc.

  May 2018, Clinical anatomy (New York, N.Y.), 31(4) (4), 525 - 534, English, International magazine

  Scientific journal


• Lumen Boundaries Extracted from Coronary Computed Tomography Angiography on Computed Fractional Flow Reserve (FFRCT): Validation with Optical Coherence Tomography.

  Uzu K, Otake Hiromasa, Choi G, Toba T, Kim HJ, Roy A, Schaap M, Grady L, Kawata M, Shinke T, Taylor CA, Hirata Ken-ichi

  Apr. 2018, EuroIntervention., English

  [Refereed]

  Scientific journal


• Impact of CD14++CD16+ monocytes on coronary plaque vulnerability assessed by optical coherence tomography in coronary artery disease patients.

  Hiroyuki Yamamoto, Naofumi Yoshida, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Kazuhiko Sakaguchi, Yushi Hirota, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Kouji Kuroda, Yoshinori Nagasawa, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-Ichi Yanaka, Takuo Emoto, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa, Ken-Ichi Hirata

  BACKGROUND AND AIMS: This study examined the impact of CD14++CD16+ monocytes on coronary plaque vulnerability, as assessed by optical coherence tomography (OCT), and investigated their association with daily glucose fluctuation. Although increased CD14++CD16+ monocyte levels have been reported to increase cardiovascular events, their impact on coronary plaque vulnerability in coronary artery disease (CAD) patients with or without diabetes mellitus (DM) remains unclear. METHODS: This prospective observational study included 50 consecutive patients with CAD, receiving lipid-lowering therapy and undergoing coronary angiography and OCT. Patients were divided into 3 tertiles according to the CD14++CD16+ monocyte percentages assessed by flow cytometry. Standard OCT parameters were assessed for 97 angiographically intermediate lesions (diameter stenosis: 30-70%). Daily glucose fluctuation was analyzed by measuring the mean amplitude of glycemic excursion (MAGE). RESULTS: CD14++CD16+ monocytes negatively correlated with fibrous cap thickness (r = -0.508, p < 0.01). The presence of thin-cap fibroatheroma (TCFA) was increased stepwise according to the tertile of CD14++CD16+ monocytes (0 [tertile 1] vs. 5 [tertile 2] vs. 10 [tertile 3], p < 0.01). CD14++CD16+ monocytes were a significant determinant of TCFA (OR 1.279, p = 0.001). In non-DM patients, a significant relationship was found between CD14++CD16+ monocytes and MAGE (r = 0.477, p = 0.018). CONCLUSIONS: CD14++CD16+ monocytes were associated with coronary plaque vulnerability in CAD patients with well-regulated lipid levels both in DM and non-DM patients. Cross-talk between glucose fluctuation and CD14++CD16+ monocytes may enhance plaque vulnerability, particularly in non-DM patients. CD14++CD16+ monocytes could be a possible therapeutic target for coronary plaque stabilization.

  Feb. 2018, Atherosclerosis, 269, 245 - 251, English, International magazine

  [Refereed]

  Scientific journal


• The first case of "locked-in leaflet" after transcatheter aortic valve replacement in a patient with bicuspid aortic stenosis.

  Nao Shibata, Kensuke Matsumoto, Takayoshi Toba, Shumpei Mori, Shinsuke Shimoyama, Hidekazu Tanaka, Toshiro Shinke, Ken-Ichi Hirata

  This case report is about an 85-year-old woman with bicuspid aortic stenosis (AS). Although preoperative multimodality imaging showed challenging anatomical aspects, transcatheter aortic valve replacement (TAVR) was selected to be performed as a less invasive alternative treatment approach, owing to her comorbidity. Postoperative transesophageal echocardiography and multidetector-row computed tomography revealed the presence of "locked-in leaflet" caused by stent distortion due to pinching by calcified native leaflets, with nodular calcification preventing the full expansion of the valve, which resulted in moderate perivalvular leakage. This is the first reported case of bicuspid AS treated with TAVR that eventually resulted in "locked-in leaflet."

  Jan. 2018, Echocardiography (Mount Kisco, N.Y.), 35(1) (1), 110 - 113, English, International magazine

  [Refereed]

  Scientific journal


• A rare case of "subcommissural adhesive aortic stenosis": Triangular struggle of aortic valve area, hemodynamics, and calcium burden.

  Hiroki Matsuzoe, Kensuke Matsumoto, Shumpei Mori, Takayoshi Toba, Hiroyuki Kawamori, Shinsuke Shimoyama, Hidekazu Tanaka, Toshiro Shinke, Ken-Ichi Hirata

  Nov. 2017, Echocardiography (Mount Kisco, N.Y.), 34(11) (11), 1717 - 1720, English, International magazine

  [Refereed]

  Scientific journal


• 心臓MSCT/MRIのPCIへの活用 石灰化が冠動脈CTの血管内腔計測と冠血流予備量比の計測に与える影響の光干渉断層法を用いた検討

  宇津 賢三, 大竹 寛雅, チョイ・ジル, 鳥羽 敬義, キム・ヒュン, ロイ・アルジュン, シャープ・ミシェル, グラディー・レオ, 松浦 啓, 河田 正仁, 森 俊平, 高谷 具史, 新家 俊郎, テイラー・チャールズ, 平田 健一

  (一社)日本心血管インターベンション治療学会, Jul. 2017, 日本心血管インターベンション治療学会抄録集, 26回, S11 - 2, English


• Spontaneous coronary artery intramural hematoma in a patient with vascular Ehlers-Danlos syndrome: Serial findings in coronary computed tomographic angiography.

  Toba T, Mori S, Yatani A, Sugisaki Y, Akita T, Sasaki N, Otake H, Shinke T, Mori H, Nishii T, Kono AK, Hirata KI

  Jul. 2017, Journal of cardiovascular computed tomography, 11(4) (4), 324 - 326

  [Refereed]


• The association between wedging of the aorta and cardiac structural anatomy as revealed using multidetector-row computed tomography.

  Mori S, Anderson RH, Takaya T, Toba T, Ito T, Fujiwara S, Watanabe Y, Nishii T, Kono AK, Hirata KI

  The aortic root is wedged within the cardiac base. The precise extent of aortic wedging, however, and its influence on the surrounding cardiac structures, has not been systematically investigated. We analysed 100 consecutive patients, who underwent coronary arterial computed tomographic angiography. We assessed the extent of aortic wedging by measuring the vertical distance between the non-adjacent aortic sinus and the inferior epicardium. A shorter distance indicates deeper aortic wedging. We assessed the tilt angle and diameter of the ascending aorta, the relative heights of the left atrial roof and the oval fossa, the shape of the proximal right coronary artery, the angle of the aorta relative to the left ventricular axis, and the lung volume. The mean extent of wedging was 42.7 ± 9.8 mm. Multivariate analysis revealed that ageing, male gender, increased body mass index, patients without cardiomyopathy, the extent of tilting and dilation of the ascending aorta, and lung volume were all independent predictors for deeper aortic wedging (R2  = 0.7400, P < 0.0001). The extent of wedging was additionally correlated with a relatively high left atrial roof (R2  = 0.1394, P < 0.0001) and oval fossa (R2  = 0.1713, P < 0.0001), the shepherd's crook shape of the proximal right coronary artery (R2  = 0.2376, P < 0.0001), and the narrowness of the angulation of the root relative to the left ventricular axis (R2  = 0.2544, P < 0.0001). In conclusion, ageing, male gender, obesity, background cardiac disease, aortic tilting and dilation, and lung volume are all correlated with the extent of wedging of the aortic root within the cardiac base.

  Jul. 2017, Journal of anatomy, 231(1) (1), 110 - 120, English, International magazine

  [Refereed]

  Scientific journal


• Diversity and Determinants of the Three-dimensional Anatomical Axis of the Heart as Revealed Using Multidetector-row Computed Tomography.

  Mori S, Anderson RH, Tahara N, Izawa Y, Toba T, Fujiwara S, Shimoyama S, Watanabe Y, Nishii T, Kono AK, Hirata KI

  Jun. 2017, Anatomical record (Hoboken, N.J. : 2007), 300(6) (6), 1083 - 1092

  [Refereed]


• The differences between bisecting and off-center cuts of the aortic root: The three-dimensional anatomy of the aortic root reconstructed from the living heart.

  Mori S, Anderson RH, Tahara N, Izawa Y, Toba T, Fujiwara S, Shimoyama S, Watanabe Y, Nishii T, Kono AK, Takahashi S, Hirata KI

  Mar. 2017, Echocardiography (Mount Kisco, N.Y.), 34(3) (3), 453 - 461

  [Refereed]


• 脂質降下療法を受けている安定狭心症における血糖変動が冠動脈病変狭窄進行に対して及ぼす影響

  山本 裕之, 新家 俊郎, 黒田 優, 大竹 寛雅, 高谷 具史, 高橋 八大, 鳥羽 敬義, 寺下 大輔, 柏木 大嗣, 宇津 賢三, 田原 奈津子, 新倉 悠斗, 黒田 浩史, 長澤 圭典, 永野 雄一朗, 築山 義郎, 谷仲 謙一, 平田 健一

  (一社)日本心血管インターベンション治療学会, Jul. 2016, 日本心血管インターベンション治療学会抄録集, 25回, MO193 - MO193, English


• ACS予後改善のための対策 急性冠症候群におけるプラスグレルのステント内血栓退縮効果 クロピドグレルとの比較検討

  築山 義朗, 上月 周, 新家 俊郎, 大竹 寛雅, 高谷 具史, 鳥羽 敬義, 黒田 優, 高橋 八大, 寺下 大輔, 宇津 賢三, 柏木 大嗣, 黒田 浩史, 新倉 悠人, 田原 奈津子, 永野 雄一郎, 長澤 圭典, 谷仲 謙一, 山本 裕之, 志手 淳也, 平田 健一

  (一社)日本心血管インターベンション治療学会, Jul. 2016, 日本心血管インターベンション治療学会抄録集, 25回, S05 - 3, English


• OMTとPCI 既知の危険因子に対して内服管理下の冠動脈疾患患者の残余リスクとしてのトランス脂肪酸濃度とプラークの脆弱性との関連の評価

  長澤 圭典, 新家 俊郎, 杜 隆嗣, 大竹 寛雅, 高橋 八大, 寺下 大輔, 宇津 賢三, 柏木 大嗣, 黒田 浩史, 新倉 悠人, 田原 奈津子, 鳥羽 敬義, 築山 義朗, 永野 雄一朗, 谷仲 謙一, 山本 裕之, 高谷 具史, 石田 達郎, 平田 健一

  (一社)日本心血管インターベンション治療学会, Jul. 2016, 日本心血管インターベンション治療学会抄録集, 25回, S06 - 4, English


• CTはPCIにどこまで使えるか? OCTおよびCCTAに基づいた冠動脈モデル間での血管内腔測定および血行力学的指標の比較 HeartFlow simulationからの識見

  鳥羽 敬義, 宇津 賢三, 森 俊平, 高谷 具史, 新家 俊郎, Choi Gilwoo, Taylor Charles, Koo Bon-Kwon, 大竹 寛雅

  (一社)日本心血管インターベンション治療学会, Jul. 2016, 日本心血管インターベンション治療学会抄録集, 25回, PD07 - 2, English


• Impact of esophageal temperature monitoring guided atrial fibrillation ablation on preventing asymptomatic excessive transmural injury.

  Kunihiko Kiuchi, Katsunori Okajima, Akira Shimane, Gaku Kanda, Kiminobu Yokoi, Jin Teranishi, Kousuke Aoki, Misato Chimura, Takayoshi Toba, Shogo Oishi, Takahiro Sawada, Yasue Tsukishiro, Tetsuari Onishi, Seiichi Kobayashi, Yasuyo Taniguchi, Shinichiro Yamada, Yoshinori Yasaka, Hiroya Kawai, Akihiro Yoshida, Koji Fukuzawa, Mitsuaki Itoh, Kimitake Imamura, Ryudo Fujiwara, Atsushi Suzuki, Tomoyuki Nakanishi, Soichiro Yamashita, Ken-Ichi Hirata, Hiroshi Tada, Hiro Yamasaki, Yoshihisa Naruse, Miyako Igarashi, Kazutaka Aonuma

  BACKGROUND: Even with the use of a reduced energy setting (20-25 W), excessive transmural injury (ETI) following catheter ablation of atrial fibrillation (AF) is reported to develop in 10% of patients. However, the incidence of ETI depends on the pulmonary vein isolation (PVI) method and its esophageal temperature monitor setting. Data comparing the incidence of ETI following AF ablation with and without esophageal temperature monitoring (ETM) are still lacking. METHODS: This study was comprised of 160 patients with AF (54% paroxysmal, mean: 24.0±2.9 kg/m(2)). Eighty patients underwent ablation accompanied by ETM. The primary endpoint was defined as the occurrence of ETI assessed by endoscopy within 5 d after the AF ablation. The secondary endpoint was defined as AF recurrence after a single procedure. If the esophageal temperature probe registered >39 °C, the radiofrequency (RF) application was stopped immediately. RF applications could be performed in a point-by-point manner for a maximum of 20 s and 20 W. ETI was defined as any injury that resulted from AF ablation, including esophageal injury or periesophageal nerve injury (peri-ENI). RESULTS: The incidence of esophageal injury was significantly lower in patients whose AF ablation included ETM compared with patients without ETM (0 [0%] vs. 6 [7.5%], p=0.028), but not the incidence of peri-ENI (2 [2.5%] vs. 3 [3.8%], p=1.0). AF recurrence 12 months after the procedure was similar between the groups (20 [25%] in the ETM group vs. 19 [24%] in the non-ETM group, p=1.00). CONCLUSIONS: Catheter ablation using ETM may reduce the incidence of esophageal injury without increasing the incidence of AF recurrence but not the incidence of peri-ENI.

  Feb. 2016, Journal of arrhythmia, 32(1) (1), 36 - 41, English, Domestic magazine

  Scientific journal


• Visualization of the radiofrequency lesion after pulmonary vein isolation using delayed enhancement magnetic resonance imaging fused with magnetic resonance angiography.

  Kunihiko Kiuchi, Katsunori Okajima, Akira Shimane, Kiminobu Yokoi, Jin Teranishi, Kousuke Aoki, Misato Chimura, Hideo Tsubata, Taishi Miyata, Yuuki Matsuoka, Takayoshi Toba, Shogo Ohishi, Takahiro Sawada, Yasue Tsukishiro, Tetsuari Onishi, Seiichi Kobayashi, Shinichiro Yamada, Yasuyo Taniguchi, Yoshinori Yasaka, Hiroya Kawai, Kazushi Ikeuchi, Yutaka Shigenaga, Takayuki Ikeda

  BACKGROUND: The radiofrequency (RF) lesions for atrial fibrillation (AF) ablation can be visualized by delayed enhancement magnetic resonance imaging (DE-MRI). However, the quality of anatomical information provided by DE-MRI is not adequate due to its spatial resolution. In contrast, magnetic resonance angiography (MRA) provides similar information regarding the left atrium (LA) and pulmonary veins (PVs) as computed tomography angiography. We hypothesized that DE-MRI fused with MRA will compensate for the inadequate image quality provided by DE-MRI. METHODS: DE-MRI and MRA were performed in 18 patients who underwent AF ablation (age, 60±9 years; LA diameter, 42±6 mm). Two observers independently assessed the DE-MRI and DE-MRI fused with MRA for visualization of the RF lesion (score 0-2; where 0: not visualized and 2: excellent in all 14 segments of the circular RF lesion). RESULTS: DE-MRI fused with MRA was successfully performed in all patients. The image quality score was significantly higher in DE-MRI fused with MRA compared to DE-MRI alone (observer 1: 22 (18, 25) vs 28 (28, 28), p<0.001; observer 2: 24 (23, 25) vs 28 (28, 28), p<0.001). CONCLUSIONS: DE-MRI fused with MRA was superior to DE-MRI for visualization of the RF lesion owing to the precise information on LA and PV anatomy provided by DE-MRI.

  Jun. 2015, Journal of arrhythmia, 31(3) (3), 152 - 8, English, Domestic magazine

  Scientific journal


• 植込み型除細動器のショック作動と予後に関する検討

  嶋根 章, 岡嶋 克則, 木内 邦彦, 横井 公宣, 寺西 仁, 青木 恒介, 千村 美里, 津端 英雄, 斎田 天, 宮田 大嗣, 高橋 八大, 鳥羽 敬義, 大石 醒悟, 三好 直貴, 月城 泰栄, 高谷 具史, 小林 征一, 山田 愼一郎, 谷口 泰代, 矢坂 義則, 林 孝俊, 横山 光宏

  (一社)日本不整脈心電学会, Mar. 2014, 心電図, 33(5) (5), 421 - 428, Japanese


• 植込み型除細動器のショック作動と予後に関する検討

  嶋根 章, 岡嶋 克則, 福沢 公二, 觀田 学, 横井 公宣, 寺西 仁, 青木 恒介, 千村 美里, 小林 征一, 高谷 具史, 月城 泰栄, 三好 直貴, 山田 愼一郎, 谷口 泰代, 矢坂 義則, 林 孝俊, 大石 醒悟, 鳥羽 敬義, 高橋 八大, 宮田 大嗣, 斎田 天, 津端 英雄, 横山 光宏

  (一社)日本不整脈心電学会, Sep. 2012, 心電図, 32(Suppl.5) (Suppl.5), S - 152, Japanese


• 植込み型除細動器(ICD)植込み時に、除細動閾値(DFT)テストは必要か?

  千村 美里, 岡嶋 克則, 嶋根 章, 福沢 公二, 横井 公宣, 觀田 学, 寺西 仁, 青木 恒介, 林 孝俊, 矢坂 義則, 谷口 泰代, 山田 愼一郎, 高谷 具史, 月城 泰栄, 三好 直貴, 大石 醒悟, 鳥羽 敬義, 小林 征一, 横山 光宏

  (一社)日本不整脈心電学会, May 2012, Journal of Arrhythmia, 28(Suppl.) (Suppl.), 165 - 165, Japanese

• Prognostic Significance of Nodular Calcification Derived from Non-contrast Coronary Computed Tomography in Percutaneous Coronary Intervention

  岩根成豪, 鳥羽敬義, 川森裕之, 廣正聖, 佐々木諭, 藤井寛之, 濱名智世, 大隅祐人, 山本哲也, 綱本浩志, 浪花祥太, 坂本優樹, 松濱考志, 福石悠太, 高橋悠, 伊澤有, 山本裕之, 高谷具史, 平田健一, 大竹寛雅

  2024, 日本循環器学会学術集会(Web), 88th


• Impact of Pericoronary Adipose Tissue Attenuation on Clinical Outcome after Percutaneous Coronary Intervention with Second-Generation Drug-Eluting Stent

  浪花祥太, 川森裕之, 鳥羽敬義, 廣正聖, 佐々木諭, 藤井寛之, 濱名智世, 大隅祐人, 山本哲也, 岩根成豪, 坂本優樹, 松濱考志, 福石悠太, 綱本浩志, 樋口功太郎, 岡本裕哉, 岩崎正道, 高谷具史, 山田愼一郎, 平田健一, 大竹寛雅

  2024, 日本循環器学会学術集会(Web), 88th


• 経カテーテル的大動脈弁置換術の術前CTから算出された細胞外液分画と患者予後との関連について

  鳥羽敬義, 川森裕之, 大竹寛雅, 柿崎俊介, 中村公一, 藤本大地, 鈴木雅貴, 伊澤有, 田中秀和, 平田健一

  2023, 日本内科学会雑誌, 112


• Evaluating Late Gadolinium Enhancement and Extracellular Volume Fraction Derived from Cardiac Magnetic Resonance Imaging to Distinguish Myocarditis from Cardiac Sarcoidosis

  藤田紘, 伊澤有, 橋村宏美, 鳥羽敬義, 藤原征, とう皓之, 鈴木雅貴, 三和圭介, 栗本浩行, 本出圭, 河野淳, 平田健一

  2023, 日本循環器学会学術集会(Web), 87th


• A rare case of concomitant aortic regurgitation and coronary ostial stenosis due to cardiovascular syphilis

  Daichi Fujimoto, Takayoshi Toba, Kenji Okada, Ken-Ichi Hirata

  Oxford University Press, 01 Mar. 2021, European Heart Journal - Case Reports, 5(3) (3), English

  Book review


• Absence of myocardial support at the base of the left coronary aortic sinus in a patient with ehlers-danlos syndrome

  Hiroyuki Toh, Shumpei Mori, Yu Izawa, Takayoshi Toba, Ken-Ichi Hirata

  Japanese Circulation Society, 01 Feb. 2021, Circulation Journal, 85(2) (2), 220, English

  Report scientific journal


• Microvasculopathy Evaluated by Dual-Energy Computed Tomography in Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Arterial Hypertension

  三和圭介, 谷口悠, 住本恵子, 松岡庸一郎, 坪井康典, 伊澤有, 鳥羽敬義, 江本憲昭, 平田健一

  2021, 日本循環器学会学術集会(Web), 85th


• Assessment of Microvasculopathy in Chronic Thromboembolic Pulmonary Hypertension after Interventional Treatment

  大西裕之, 谷口悠, 住本恵子, 松岡庸一郎, 伊澤有, 坪井康典, 鳥羽敬義, 大竹寛雅, 小林成美, 江本憲昭, 平田健一

  2020, 日本循環器学会学術集会(Web), 84th


• High Wall Shear Stress was Strongly Associated with Plaque Vulnerability in Computational Fluid Dynamics with Combined Optical Coherence Tomography and Heartflow FFRCT Simulation

  Takayoshi Toba, Gilwoo Choi, Yuichiro Nagano, Hiroyuki Kawamori, Toshiro Shinke, Charles Taylor, Hiromasa Otake

  Oct. 2017, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B186 - B186, English

  Summary international conference


• The combination of rosuvastatin (10mg) and eicosapentaenoic acid (1800mg) improved native coronary plaques > 5.7 years after stent implantation

  Youichirou Sugizaki, Hiromasa Otake, Toshiro Shinke, Hiroyuki Kawamori, Koji Kuroda, Takayoshi Toba, Yuto Shinkura, Yuichiro Nagano, Hiroyuki Yamamoto, Hiroyuki Onishi

  Oct. 2017, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B220 - B220, English

  Summary international conference


• The clinical impact of daily glucose fluctuation on cardiovascular events in patients with stable angina pectoris pretreated with lipid-lowering therapy

  Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Yuto Shinkura, Koji Kuroda, Yuichiro Nagano, Takayoshi Toba, Youichirou Sugizaki, Hiroyuki Onishi, Ken-ichi Hirata

  Oct. 2017, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B331 - B331, English

  Summary international conference


• 血清リン値は重度大動脈弁狭窄症患者の総大動脈石灰化負荷量を予測する(Serum Phosphate Level Predicts Total Aortic Calcification Burden in Patients with Severe Aortic Stenosis)

  Terashita Daisuke, Mori Shunpei, Tahara Natsuko, Izawa Yu, Toba Takayoshi, Matsuzoe Hiroki, Matsumoto Kensuke, Tanaka Hidekazu, Ohtake Hiromasa, Shinke Toshiro, Nishii Tatsuya, Kono Atsushi, Fujiwara Sei, Hirata Ken-ichi

  (一社)日本循環器学会, Mar. 2017, 日本循環器学会学術集会抄録集, 81回, OE - 322, English


• 経胸壁心エコーでの推定とCTでの計測による左室流出路面積の比較(Comparison of the Left Ventricular Outflow Tract Area Estimated by Transthoracic Echocardiography and Measured by Computed Tomography)

  Izawa Yu, Mori Shunpei, Tahara Natsuko, Terashita Daisuke, Toba Takayoshi, Fujiwara Sei, Matsuzoe Hiroki, Matsumoto Kensuke, Tanaka Hidekazu, Ohtake Hiromasa, Shinke Toshiro, Nishii Tatsuya, Kohno Atsushi, Hirata Ken-ichi

  (一社)日本循環器学会, Mar. 2017, 日本循環器学会学術集会抄録集, 81回, PE - 193, English


• 大動脈弁石灰化の密度は大動脈弁口面積に依存することなく大動脈弁狭窄の血行動態的重症度を予測する(Aortic Valve Calcification Density Predicts the Hemodynamic Severity of Aortic Stenosis Independently of Aortic Valve Area)

  鳥羽 敬義, 森 俊平, 田原 奈津子, 伊澤 有, 寺下 大輔, 松添 弘樹, 松本 賢亮, 田中 秀和, 大竹 寛雅, 藤原 征, 新家 俊郎, 西井 達矢, 河野 淳, 平田 健一

  (一社)日本循環器学会, Mar. 2017, 日本循環器学会学術集会抄録集, 81回, PJ - 386, English


• 心臓CTを契機に診断に至ったスタックバルブの一例

  田原奈津子, 森俊平, 下山真介, 伊澤有, 鳥羽敬義, 木内邦彦, 藤原征, 平田健一

  2017, 日本循環器学会近畿地方会(Web), 124th


• Current status and future perspective of optical coherence tomography in the management of coronary artery disease

  鳥羽 敬義, 大竹 寛雅, 新家 俊郎

  医歯薬出版, 05 Nov. 2016, 医学のあゆみ, 259(6) (6), 631 - 637, Japanese


• Why does thin-cap fibroatheroma cluster in the proximal segment in left anterior coronary artery, but are evenly distributed throughout the entire right coronary artery? Results from computational fluid dynamics simulation by CT-FFR

  Takayoshi Toba, Gilwoo Choi, Kenzo Uzu, Toshiro Shinke, Bon-Kwon Koo, Charles Taylor, Hiromasa Otake

  Nov. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B243 - B243, English

  Summary international conference


• Impaired HDL uptake capacity which measure HDL functionality may associate with target lesion revascularization through provoking neoatherosclerosis formation after stent implantation

  Yuichiro Nagano, Hiromasa Otake, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Yasuhiro Irino, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Koji Kuroda, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Yoshinori Nagasawa, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Toshiro Shinke, Tatsuro Ishida, Ryuji Toh, Ken-Ichi Hirata

  Nov. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B136 - B136, English

  Summary international conference


• Potent effect of prasugrel on acute phase resolution of intra-stent tissue after percutaneous intervention to acute coronary syndrome

  Yoshiro Tsukiyama, Amane Kozuki, Toshiro Shinke, Hiromasa Otake, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Koji Kuroda, Yuto Shinkura, Natsuko Tahara, Yoshinori Nagasawa, Yuichiro Nagano, Kenichi Yanaka, Hiroyuki Yamamoto, Junya Shite, Ken-ichi Hirata

  Nov. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B239 - B240, English

  Summary international conference


• Efficacy of aggressive balloon pulmonary angioplasty on chronic thromboembolic pulmonary hypertension beyond normalized mean pulmonary arterial pressure

  Yuto Shinkura, Kazuhiko Nakayama, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Koji Kuroda, Natsuko Tahara, Yoshinori Nagasawa, Yuichiro Nagano, Hiroyuki Yamamoto, Yoshiro Tsukiyama, Kenichi Yanaka, Naoki Tamada, Hiromasa Otake, Toshiro Shinke, Noriaki Emoto, Ken-ichi Hirata

  Nov. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B37 - B37, English

  Summary international conference


• Efficacy and safety of sequential hybrid therapy with pulmonary endarterectomy and additional balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension

  Kenichi Yanaka, Kazuhiko Nakayama, Toshiro Shinke, Hiromasa Otake, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Yuto Shinkura, Koji Kuroda, Kenzo Uzu, Natsuko Tahara, Yoshinori Nagasawa, Yuichiro Nagano, Naoki Tamada, Yoshiro Tsukiyama, Hiroyuki Yamamoto, Noriaki Emoto, Ken-ichi Hirata

  Nov. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 68(18) (18), B36 - B37, English

  Summary international conference


• EVALUATION OF LOCAL HEMODYNAMIC FORCES ACTING ON PLAQUE MAY HELP PREDICT PLAQUE VULNERABILITY: LESSONS FROM COMBINED ANALYSIS OF OPTICAL COHERENCE TOMOGRAPHY AND COMPUTATIONAL FLUID DYNAMICS SIMULATION

  Kenzo Uzu, Gilwoo Choi, Hyun Jin Kim, Arjun Roy, Trang Nguyen, Michiel Schaap, Leo Grady, Takayoshi Toba, Shumpei Mori, Tomofumi Takaya, Toshiro Shinke, Bon-Kwon Koo, Charles Taylor, Hiromasa Otake

  Apr. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 319 - 319, English

  Summary international conference


• IMPACT OF PRECISION OF LUMEN BOUNDARY EXTRACTED FROM CORONARY CT ON FFRCT: VALIDATION WITH OCT

  Takayoshi Toba, Gilwoo Choi, Kenzo Uzu, Hyun Jin Kim, Arjun Roy, Tran Nguyen, Michiel Schaap, Leo Grady, Shumpei Mori, Tomofumi Takaya, Toshiro Shinke, Charles Taylor, Hiromasa Otake

  Apr. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 315 - 315, English

  Summary international conference


• IMPACT OF WALL SHEAR STRESS AND AXIAL PLAQUE STRESS ON CORONARY PLAQUE INITIATION AND PROGRESSION

  Takayoshi Toba, Gilwoo Choi, Hyun Jin Kim, Arjun Roy, Tran Nguyen, Michiel Schaap, Leo Grady, Kenzo Uzu, Shumpei Mori, Tomofumi Takaya, Toshiro Shinke, Bon-Kwon Koo, Charles Taylor, Hiromasa Otake

  Apr. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 1755 - 1755, English

  Summary international conference


• CORRELATION OF WALL SHEAR STRESS AND AXIAL PLAQUE STRESS BETWEEN MODELS DERIVED FROM CT AND OCT DATA

  Gilwoo Choi, Kenzo Uzu, Takayoshi Toba, Hyun Jin Kim, Arjun Roy, Tran Nguyen, Leo Grady, Tomofumi Takaya, Shumpei Mori, Toshiro Shinke, Bon Kwon Koo, Charles Taylor, Hiromasa Otake

  Apr. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 1772 - 1772, English

  Summary international conference


• THE IMPACT OF SERUM TRANS FATTY ACIDS CONCENTRATION ON PLAQUE VULNERABILITY IN PATIENTS WITH CORONARY ARTERY DISEASE UNDER MANAGEMENT OF CONVENTIONAL RISK FACTORS: ASSESSMENT VIA OPTICAL COHERENCE TOMOGRAPHY

  Yoshinori Nagasawa, Toshiro Shinke, Ryuji Toh, Hiromasa Otake, Tomofumi Takaya, Takayoshi Toba, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Daiji Kashiwagi, Koji Kuroda, Yuto Shinkura, Natsuko Tahara, Hiroyuki Yamamoto, Yoshiro Tsukiyama, Kenichi Yanaka, Yuichiro Nagano, Tatsuro Ishida, Ken-Ichi Hirata

  Apr. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 361 - 361, English

  Summary international conference


• INVESTIGATION OF HEMODYNAMIC CHANGES DURING BALLOON OCCLUSION TEST FOR PERCUTANEOUS ATRIAL SEPTAL DEFECT CLOSURE

  Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Tomofumi Takaya, Masaru Kuroda, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Koji Kuroda, Natsuko Tahara, Daiji Kashiwagi, Yoshinori Nagasawa, Yoshiro Tsukiyama, Kenichi Yanaka, Ken-Ichi Hirata

  Apr. 2016, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 935 - 935, English

  Summary international conference


• 多列検出器コンピュータ断層撮影画像を用いた生体心の臨床解剖解析

  森俊平, 高谷具史, 樫尾和洋, 笠松朗, 伊藤達郎, 鳥羽敬義, 藤原征, 西井達矢, 河野淳, 寺島俊雄, 平田健一

  2016, 日本解剖学会総会・全国学術集会講演プログラム・抄録集, 121st


• Accuracy of lumen boundary extracted from coronary CTA for calcified and noncalcified plaques assessed using OCT data

  Gilwoo Choi, Kenzo Uzu, Takayoshi Toba, Shumpei Mori, Tomofumi Takaya, Toshiro Shinke, Arjun Roy, Tran Nguyen, Sophie Khem, Charles A. Taylor, Hiromasa Otake

  Oct. 2015, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B134 - B134, English

  Summary international conference


• Combined use of intravascular ultrasound and optical coherence tomography during percutaneous coronary intervention may reduce target lesion revascularization after percutaneous coronary intervention

  Daiji Kashiwagi, Hiromasa Otake, Toshiro Shinke, Tomofumi Takaya, Hiroto Kinutani, Takayoshi Toba, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Koji Kuroda, Yuto Shinkura, Natsuko Tahara, Yoshinori Nagasawa, Ken-ichi Hirata

  Oct. 2015, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B146 - B146, English

  Summary international conference


• 心臓専用半導体SPECT装置を用いたMIBG心筋シンチにおけるH/M比算出法の検討

  樫尾 和洋, 高谷 具史, 伊藤 達郎, 笠松 朗, 鳥羽 敬義, 河野 淳, 西井 達夫, 森 俊平, 藤原 征, 平田 健一

  (一社)日本核医学会, Sep. 2015, 核医学, 52(3) (3), 256 - 256, Japanese


• 高カリウム血症が原因で植込み型除細動器の不適切作動を来した1例

  青木恒介, 岡嶋克則, 嶋根章, 福沢公二, 福沢公二, 觀田学, 横井公宣, 寺西仁, 千村美里, 林孝俊, 矢坂義則, 谷口泰代, 山田愼一郎, 小林征一, 高谷具史, 月城泰栄, 三好直貴, 大石醒悟, 鳥羽敬義, 横山光宏

  2012, 日本循環器学会近畿地方会(Web), 113th


• 偶発性低体温症に伴う心室細動に対して,PCPSによる復温で対処した1例

  立石直毅, 岩田幸代, 高谷具史, 林孝俊, 谷口泰代, 山田愼一郎, 岡嶋克則, 嶋根章, 福沢公二, 觀田学, 三好直貴, 横井公宣, 水口幸生, 淀井景子, 大石醒悟, 柴田浩遵, 鳥羽敬義, 梶谷定志

  2011, 日本循環器学会近畿地方会(Web), 111th


• 短期間に3度の心肺蘇生を施行した,冠攣縮性狭心症を合併した肥大型心筋症の一例

  高橋八大, 林孝俊, 谷口泰代, 山田愼一郎, 岡嶋克則, 嶋根章, 小林征一, 福沢公二, 高谷具史, 月城泰栄, 觀田学, 横井公宣, 三好直貴, 寺西仁, 大石醒悟, 鳥羽敬義, 青木恒介, 斎田天, 千村美里, 吉岡悠太郎, 横山光宏

  2011, 日本循環器学会近畿地方会(Web), 112th


• 心筋障害及び左室内血栓を伴うSLE症候群の1例

  上野大輔, 大石醒悟, 鳥羽敬義, 寺西仁, 三好直貴, 月城泰栄, 觀田学, 横井公宣, 高谷具史, 福沢公二, 嶋根章, 岡嶋克則, 山田愼一郎, 谷口泰代, 林孝俊, 西岡成知, 森本直人, 向原伸彦, 松本賢亮, 横山光宏

  2011, 日本循環器学会近畿地方会(Web), 112th


• 心房細動に伴う急性動脈閉塞に対して,シースを使用して回避的に両下肢を還流し救肢し得た1例

  吉岡悠太郎, 山田愼一郎, 高谷具史, 鳥羽敬義, 林孝俊, 谷口泰代, 岩田幸代, 岡嶋克則, 嶋根章, 福沢公二, 觀田学, 三好直貴, 横井公宣, 水口幸生, 淀井景子, 大石醒悟, 柴田浩遵, 西岡成知, 福隅正臣, 中桐啓太郎, 梶谷定志

  2011, 日本循環器学会近畿地方会(Web), 111th


• 心筋障害を残すことなく救命し得た左冠動脈主幹部の急性冠症候群に伴う心原性ショックの1例

  鳥羽敬義, 山田愼一郎, 立石直毅, 高谷具史, 林孝俊, 谷口泰代, 岩田幸代, 岡嶋克則, 嶋根章, 福沢公二, 觀田学, 三好直貴, 横井公宣, 水口幸生, 淀井景子, 大石醒悟, 柴田浩遵, 梶谷定志

  2011, 日本循環器学会近畿地方会(Web), 111th


• 陳旧性心筋梗塞,大動脈弁置換術後の心室頻拍に対し経心房中隔アプローチでアブレーションを施行した1例

  觀田学, 岡嶋克則, 嶋根章, 福沢公二, 林孝俊, 谷口泰代, 山田愼一郎, 岩田幸代, 高谷具史, 横井公宣, 三好直貴, 水口幸生, 大石醒悟, 淀井景子, 鳥羽敬義, 柴田浩遵, 梶谷定志

  2011, 日本循環器学会近畿地方会(Web), 111th


• 僧帽弁輪下壁に回路を有する心室頻拍に対してカテーテルアブレーションが有効であった陳旧性心筋梗塞の一例

  青木恒介, 岡嶋克則, 嶋根章, 福沢公二, 觀田学, 横井公宣, 寺西仁, 林孝俊, 谷口泰代, 山田愼一郎, 小林征一, 高谷具史, 月城泰栄, 三好直貴, 大石醒悟, 鳥羽敬義, 高橋八大, 吉岡悠太郎, 千村美里, 斎田天, 横山光宏

  2011, 日本循環器学会近畿地方会(Web), 112th


• 僧帽弁輪部起源の心室性期外収縮に対してカテーテルアブレーションが有効であった一例

  鳥羽敬義, 岡嶋克則, 柴田浩遵, 大石醒悟, 淀井景子, 水口幸生, 三好直貴, 觀田学, 横井公宣, 高谷具史, 嶋根章, 岩田幸代, 水谷和郎, 山田愼一郎, 谷口泰代, 林孝俊, 梶谷定志

  2010, 日本循環器学会近畿地方会(Web), 110th


• 心肺蘇生に伴う前縦隔血腫を認めた急性心筋梗塞の1例

  本間丈博, 大石醒悟, 柴田浩遵, 鳥羽敬義, 淀井景子, 水口幸生, 三好直貴, 觀田学, 横井公宣, 高谷具史, 嶋根章, 岡嶋克則, 岩田幸代, 水谷和郎, 山田愼一郎, 谷口泰代, 林孝俊, 村上博久, 向原伸彦, 梶谷定志

  2010, 日本循環器学会近畿地方会(Web), 110th

• Elucidation of pathogenesis and development of prophylaxis of lower extremity arterial disease using optical coherence tomography and single-cell RNA sequence analysis

  鳥羽 敬義

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Kobe University, 01 Apr. 2023 - 31 Mar. 2025

  本研究では、冠動脈疾患で臨床使用可能な方向性冠動脈粥種切除術を用いて下肢動脈のプラークを採取し、そのサンプルを用いて臨床の画像で得られる所見に対する病理学的な所見の根拠を示すこと、および光干渉断層法の形態的情報と組織学的な評価、そしてシングルセル解析（scRNAseq）との関連を評価し、下肢閉塞性動脈疾患の新たな治療ターゲットの同定の臨床応用の足掛かりを作ることを目的としている。本目的を達成すべく、「光干渉断層法と方向性冠動脈粥腫切除術を用いた下肢動脈プラークの組織性状評価に関する探索的臨床研究」（jRCTs052230061）、「方向性冠動脈粥腫切除術とシングルセル解析を用いた下肢動脈プラークの分子細胞生物学的特徴に関する探索的臨床研究」（jRCTs052230062）を立ち上げ、2023年7月に特定臨床研究として神戸大学臨床研究審査委員会の承認を得た。現在、症例の登録および下肢プラークサンプルの取得および解析を進めているところである。「光干渉断層法と方向性冠動脈粥腫切除術を用いた下肢動脈プラークの組織性状評価に関する探索的臨床研究」に関しては、登録予定数4例に対して3例、「方向性冠動脈粥腫切除術とシングルセル解析を用いた下肢動脈プラークの分子細胞生物学的特徴に関する探索的臨床研究」に関しては、予定登録数12例に対して5例の登録が完了している。これらの研究を通じて、臨床の画像で得られる所見に対する病理学的な所見の根拠を示すことができると同時に、シングルセル解析を用いることで末梢動脈血管におけるイベント抑制のための新たなターゲットを見つけることができる可能性がある。