Research activity information

• 杉本健, 増田博亮, 小澤麻由子, 直野健, 姉崎久敬, 廣江葵, 藤原彩子, 宮田吉晴, 川井享代, 榑林陽一, 機械学習を用いたリスク予測モデルによる個別改善効果推定手法の提案

  杉本健, 増田博亮, 小澤麻由子, 直野健, 姉崎久敬, 廣江葵, 藤原彩子, 宮田吉晴, 川井享代, 榑林陽一

  2025, FIT講演論文集, 第2分冊, 535 - 540


• Relationship between Commuting Distance Using Public Transportation and the Risk of SARS-CoV-2 Infection in Healthcare Workers in Japan: A Cross-sectional Study

  Hashimoto R., Teramoto K., Ogata S., Iihara K., Miyata Y., Kurebayashi Y., Nishimura K.

  2025, Kobe J. of Med. Sci., 71, E10-18

  Link to Kobe Univ. Repository (Kernel)


• がん患者を対象とした生活情報の記録基盤の構築に関する前向き観察研究

  川井享代, 廣江葵, 宮田吉晴, 榑林陽一

  2024, 癌と化学療法, 52, 225 - 229

  [Refereed]


• Mouse tissue glycome atlas 2022 highlights inter-organ variation in major N-glycan profiles.

  Otaki M., Hirane N., Natsume-Kitatani Y., Itoh M., Shindo M., Kurebayashi Y., Nishimura S.

  Dec. 2022, Sci. Rep., 12(1):17804., doi: 10.1038/s41598-022-21758-4


• 臨床オミクスデータと人工知能を活用した革新的な創薬標的探索プラットフォームの構築 ～内閣府官民研究開発投資拡大プログラム（PRISM）での取組み～

  榑林 陽一, 夏目やよい, 進藤順紀, 中村恵宣, 川井享代

  2022, Pharm. Tech. Japan, 38, 1291 - 1296


• 新薬創出を加速する人工知能の開発~データ駆動型創薬ターゲット探索プラットフォームの構築

  夏目やよい, 榑林陽一

  2021, あいみっく, 42(3) (3), 58 - 62


• アカデミア創薬Hit to Lead支援の最前線：東京大学創薬機構構造展開ユニットのあゆみ

  宮地 弘幸, 安田 公助, 金光 佳世子, 榑林 陽一

  2021, MEDCHEM NEWS, 31, 13 - 16


• Translational science: Key features, issues and future perspectives.

  Kurebayashi Y

  2019, Translat Regulat Sci., 1, 1 - 3


• Effects of VLA-1 blockade on experimental inflammation in mice.

  Totsuka R, Kondo T, Matsubara S, Kurebayashi Y

  2016, Kobe J. of Med. Sci., 61(37) (37), 27

  Link to Kobe Univ. Repository (Kernel)


• Effects of topical application of betamethasone on imiquimod-induced psoriasis-like skin inflammation in mice.

  Mori H, Arita K, Yamaguchi T, Hirai M, Kurebayashi Y

  2016, Kobe J. of Med. Sci., 62, 79 - 88

  Link to Kobe Univ. Repository (Kernel)


• Application of Physiologically-Based Pharmacokinetic Modeling for the Prediction of Tofacitinib Exposure in Japanese

  Suzuki M, Tse S, Hirai M, Kurebayashi Y

  2016, Kobe J. of Med. Sci., 62, 150 - 161

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• 我が国の医療イノベーションの課題と展望

  榑林陽一

  2015, 経済人, 69, 23 - 23


• 行政の立場から:わが国の医薬品開発における「創薬支援ネットワーク」の役割

  榑林陽一

  2015, 医薬ジャーナル, 51, 69 - 74


• ジャパンキャンサーリサーチ・プロジェクトと創薬支援ネットワークの連携協力に向けて

  榑林陽一

  2015, 臨床評価, 43, 129 - 131


• 消化管知覚と病態への関与 IBS(過敏性腸症候群）の発症メカニズム

  土井(大橋, 雅津代, 榑林 陽一

  2011, 医学の歩み, 238, 917 - 922


• Tertiary structure-related activity of tick defensin (persulcatusin) in the taiga tick, Ixodes persulcatus.

  Isogai E, Isogai H, Okumura K, Hori H, Tsuruta H, Kurebayashi Y

  2011, Exp. Appl. Acar., 51, 71 - 77


• Expression, crystallization and preliminary X-ray diffraction studies of thermostable β-1,3-xylanase from Thermotoga neapolitana strain DSM 4359.

  Okazaki F, Ogino C, Kondo A, Mikami B, Kurebayashi Y

  2011, Acta Cryst., 67, 779 - 781


• A selective, high affinity 5-HT2B receptor antagonist inhibits visceral hypersensitivity in rats.

  Ohashi-Doi K, Himaki D, Nagao K, Kawai M, Gale JD, Furness JB, Kurebayashi, Y

  2010, Neurogastroenterol. Motil., 22, 69 - 76


• Pregabalin inhibits accelerated defecation and decreased colonic nociceptive threshold in sensitized rats.

  Ohashi-Doi K, Gale J, Kurebayashi Y

  2010, Eur. J. Pharmacol., 643, 107 - 112


• 過敏性腸症候群の内臓痛覚過敏モデルと創薬ターゲット

  土井(大橋, 雅津代, 榑林 陽一

  2009, 日本薬理学雑誌, 133, 194 - 198


• N-(2-Hydroxyethyl)-N,2-dimethyl-8- {[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease.

  Mori H, Tonai-Kachi H, Ochi Y, Taniguchi Y, Ohshiro H, Takahashi T, Aihara T, Hirao A, Kato T, Sakakibara M, Kurebayashi Y

  2009, J. Pharmacol. Exp. Ther., 328, 671 - 667


• Effect of mexiletine on dynamic allodynia induced by chronic constriction injury of the sciatic nerve in rats.

  Nakazato-Imasato E, Tanimoto-Mori S

  2009, J. Vet. Med. Sci., 71, 991 - 994


• Pharmacological characteristics of the hind paw weight bearing difference induced by chronic constriction injury of the sciatic nerve in rats.

  Nakazato-Imasato, E, Kurebayashi Y

  2009, Life Sci., 84, 622 - 626


• MicroPET detection of regional brain activation induced by colonic distention in a rat model of visceral hypersensitivity.

  Ohashi K, Ichikawa K, Chen L, Callehan M, Zasadny K, Kurebayashi Y

  2008, J. Vet. Med. Sci., 70, 43 - 49


• Abolishment of TNBS-induced visceral hypersensitivity in mast cell-deficient rats.

  Ohashi K, Sato Y, Kawai M, Kurebayashi Y

  2008, Life Sci., 82, 419 - 423


• Effect of catechin diet on gingivitis in cats.

  Isogai H, Isogai E, Takahashi K, Kurebayashi Y

  2008, Int. J. Appl. Res. Vet. Med., 6, 82 - 86


• Detection of InvA, SpiC, SipC, InvF and HilA in Salmonella isolated from beef and poultry by Dot Blot Hybridization in Zambia.

  Hangombe BM, Isogai E, Mubita C, Isogai N, Sinlungwe M, Chisenga C, Moonga L, Mulenga E, Yabe J, Takaya A, Yamamoto T, Kurebayashi Y, Isogai H

  2008, Int. J. Appl. Res. Vet. Med., 6, 1 - 6


• Effect of a new a2d ligand PD-217014 on visceral hypersensitivity induced by 2,4,6-trinitrobenzene sulfonic acid in rats.

  Ohashi K, Kawai M, Ninomiya N, Taylor C, Kurebayashi Y

  2008, Pharmacology, 81, 144 - 150


• 家庭内における除菌のための手洗い効果と環境表面からの細菌の検出

  磯貝恵美子, 西川武志, 磯貝浩, 磯貝なゆた, 榑林陽一, 林俊治

  2007, 環境感染, 22, 175 - 180


• 歯科病院環境の真菌学的検討，病院環境におけるStachybotrys chartarum, Aspergillus niger and Chaetomium funicoleの分離，

  磯貝恵美子, 小林美智代, 奥村一彦, 磯貝浩, 榑林陽一, 林俊治

  2007, 環境感染, 23, 260 - 264


• Colonic mast cell infiltration in rats with TNBS-induced visceral hypersensitivity.

  Ohashi K, Sato Y, Iwata H, Kawai M, Kurebayashi Y

  2007, J. Vet. Med. Sci., 69, 1223 - 1228


• Synthesis and pharmacological activities of novel bicyclic thiazoline derivertives as hepatoprotective agents. I. 8-Ethoxycarbonyl-5,6-dihydrothiazolo[2,3-c] [1,4]thiazine derivatives. Chem. Pharm. Bull.

  Hasegawa H, Nakayama A, Hosokami T, Kurebayashi Y, Ikeda T, Shimoto Y, Ide S, Honda Y, Suzuki N

  1995, Chem. Pharm. Bull., 43, 78 - 83


• Synthesis and pharmacological activities of novel bicyclic thiazoline derivertives as hepatoprotective agents. II. (7-Alkoxycarbonyl-2,3,5,6-tetrahydro-pyrrolo [2,1-b]thiazol-3-ylidene) acetamide derivatives.

  Hasegawa H, Nakayama A, Hosokami T, Kurebayashi Y, Ikeda T, Shimoto Y, Ide S, Honda Y, Suzuki N

  1995, Chem. Pharm. Bull., 43, 1125 - 1131


• Species- and organ-specificity and expression of 105 kD liver cell membrane glycoprotein antigen during rat development. J. Vet. Med. Sci.

  Ikeda T, Minami M, Kurebayashi Y

  1993, J. Vet. Med. Sci., 55, 415 - 420


• Antisecretory and antiulcer effects of ebselen, a seleno- organic compound, in rats.

  Tabuchi Y, Kurebayashi Y

  1993, Jpn. J. Pharmacol., 61, 255 - 257


• Protection by 16, 16-dimethyl prostaglandin E2 and dibutyryl cyclic AMP against complement-mediated hepatic necrosis in rats.

  Kurebayashi Y, Honda Y

  1992, Hepatology, 19, 545 - 550


• Protective effect of 16, 16-dimethyl prostaglandin E2 on isolated rat hepatocytes against complement-mediated immune attack.

  Kurebayashi Y, Ikeda T, Honda Y

  1992, Dig. Dis. Sci., 37, 645 - 649


• Effect of DS-4574, a novel peptidoleukotriene antagonist with mast cell stabilizing action, on acute gastric lesions and gastric secretion in rats.

  Tabuchi Y, Kurebayashi Y

  1992, Jpn. J. Pharmacol., 60, 335 - 340


• A rat model of acute liver necrosis induced by a monoclonal antibody to liver specific antigen and complement.

  Ikeda T, Kurebayashi Y

  1991, Hepatology, 13, 1152 - 1157


• Antiulcer effects of 3-{[2(3,4-dimethoxyphenyl]carbamoyl]methyl]-amino-N-methyl-benzamide in experimental gastric and duodenal ulcers.

  Asano M, Kurebayashi Y, Ryokawa Y, Hashizume T, Akashi A

  1990, Arzneim. Forsch/Drug Res., 40, 276 - 281


• Colonization of Helicobacter pylori in the gastric mucosa of mongorian gerbis.

  Yokota K, Kurebayashi Y, Takayama Y, Hayashi S, Isogai H, Isogai E, Imai K, Yabana T, Yachi A, Oguma K

  1990, Microbiol Immunol, 35, 475 - 480


• 胃壁中のCampylobacter pyloriの同定法の検討と血中抗菌抗体価の測定

  横田憲治, 小熊恵二, 吉田博清, 高山義一, 杉山敏郎, 矢花剛, 谷内昭, 榑林陽一, 磯貝浩, 磯貝恵美子

  1989, 感染症学雑誌, 64, 597 - 603


• Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats.

  Kurebayashi Y, Tabuchi Y, Akasaki M

  1989, Arzneim. Forsch./Drug Res., 39, 250 - 253


• Chemiluminescence and phagocytic response of rat polymorphonuclear neutrophils to leptospiras.

  Isogai E, Isogai H, Wakizaka H, Miura H, Kurebayashi Y

  1989, Zbl. Bakt. Hyg., 272, 34 - 36


• Cytoprotective action of cetraxate against HCl ethanol-induced gastric lesion in rats.

  Kurebayashi Y, Ikeda T, Osada Y

  1987, Jpn. J. Pharmacol., 46, 17 - 25


• Malotilateの実験的肝障害に対する作用（第2報）四塩化炭素肝障害・治癒促進効果

  橋爪武司, 榑林陽一, 下東義正, 大西美穂子, 森敬子, 明石章

  1986, 薬理と治療, 14, 2075 - 2092


• 抗肝細胞膜モノクローナル抗体の静脈内投与による実験的ラット急性肝障害モデル

  榑林陽一, 佐藤敬喜, 片見一衛, 小河秀正, 長田恭明

  1986, 医学の歩み, 146, 179 - 180


• Impaired function of Brunner's glands and duodenal ulcer formation in rats.

  Kurebayashi Y, Inoue M, Asano M, Hashizume T, Akashi A

  1986, Asia Pacific J. Pharmacol., 1, 5 - 16


• Biological activities of leptospiral lipopolysaccharide.

  Isogai E, Isogai H, Kurebayashi Y, Ito N

  1986, Zbl. Bakt. Hyg., A261, 53 - 64


• Phagocytosis as a defense mechanism against infection with leptospiras.

  Isogai E, Kitagawa H, Isogai H, Kurebayashi Y

  1986, Zbl. Balk. Hyg., A261, 65 - 74


• Changes in duodenal mucosal blood flow and mucus glycoprotein content during cysteamine-induced duodenal ulceration in rats.

  Kurebayashi Y, Asano M, Hashizume T, Akashi A

  1985, Arch. Int. Pharmacodyn. Therap., 276, 152 - 162


• マロチレートのラット実験的肝障害に対する作用

  橋爪武, 大西美穂, 榑林陽一, 森敬子, 井上実, 明石章

  1984, 臨床と研究, 62, 335 - 343


• Gastric hyperacidity and duodenal ulcer formation induced by dulcerozine in rats.

  Kurebayashi Y, Asano M, Hashizume T, Akashi A

  1984, Jpn. J. Pharmacol., 36, 121 - 123


• Dulcerozine-induced duodenal ulcers in rats: A simple highly-reliable model for evaluating antiulcer agents.

  Kurebayashi Y, Asano M, Hashizume T, Akashi A

  1984, Arch. Int. Pharmacodyn. Therap., 271, 155 - 168


• Dulcerozineによるラット十二指腸潰瘍の特性

  浅野昌英, 榑林陽一, 橋爪武司, 明石章

  1983, 医学のあゆみ, 124, 183 - 186


• ラット実験潰瘍におよぼすセトラキサートの作用

  浅野正英, 榑林陽一, 橋爪武, 明石章

  1983, 臨床と研究, 60, 347 - 352


• Evaluation of prophylactic activity of drugs on swine gastroesophageal ulcer induced by betazole-reserpine using the method of endoscopy.

  Kokue E, Kurebayashi Y, Shimoda M, Hayama T

  1983, Jpn. J. Vet. Sci., 45, 143 - 149


• Three compartment model for pyrimethamine disposition in the pig.

  Shimoda M, Kokue E, Kurebayashi Y, Hayama T

  1981, J. Vet. Pharmacol. Therap., 4, 165 - 170


• Serial endoscopic observation of swine gastroesophageal ulceration induced by injection of a histamine-oil-beeswax mixture

  Kokue E, Kurebayashi Y, Shimoda M, Hayama T

  1981, Am. J. Vet. Res., 42, 1807 - 1810


• Antihypertensive and general pharmacological properties of budralazine.

  Chiba T, Shibamura S, Tanaka M, Yamasaki H, Hashimoto H, Kurebayashi Y, Kasai Y, Ryokawa Y, Tamura K, Hirohashi M, Akashi A

  1981, Arzneim. Forsch /Drug Res., 31, 1080 - 1087


• Rat forestomach ulcer induced by drinking glucose solution as an experimental model of gastroesophageal ulcer of the swine.

  Kokue E, Kurebayashi Y

  1980, Jpn. J. Vet. Sci., 42, 395 - 399


• Secretory kinetics of electrolytes in porcine gastric juice from Heidenhain pouch.

  Fujita S, Kokue E, Kurebayashi Y, Hayama T

  1980, Jpn. J. Vet. Sci., 42, 401 - 406

• A Proposal for Personalized Improvement Effect Estimation Method Using Machine Learning-Based Risk Prediction Models

  杉本健, 増田博亮, 小澤麻由子, 直野健, 姉崎久敬, 廣江葵, 藤原彩子, 宮田吉晴, 川井享代, 榑林陽一

  2025, 情報科学技術フォーラム講演論文集, 24th


• A Prospective Clinical Study on the Continuation Rate of Recording Electronic Patient-Reported Outcomes and Electronic Medication Notebook by Patients and the Rate of Information Reference by Attending Physicians in Cancer Chemotherapy

  川井享代, 川井享代, 廣江葵, 宮田吉晴, 榑林陽一

  2025, 癌と化学療法, 52(3) (3)