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SASAKI Ryohei
University Hospital / Radiation Oncology
Professor

Researcher basic information

■ Research news
■ Research Keyword
  • Particle therapy
  • Exosome
  • Medical device
  • Oncology
  • Radiation biology
  • Radiation oncology
■ Research Areas
  • Life sciences / Radiology
■ Committee History
  • Dec. 2014 - Nov. 2024, JASTRO, Director, Editor-in-chief
  • Apr. 1994 - Mar. 2020, 日本医学放射線学会, 評議員

Research activity information

■ Award
  • Oct. 2024 Ministry of Education, Culture, Sports, Science and Technology, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Awards for Science and Technology, Development Category, 吸収性スペーサーを用いた体内空間可変粒子線治療の開発
    Ryohei Sasaki,Takumi Fukumoto, Yusuke Demizu, Tsutomu Obata

  • Oct. 2023 Kobe university, president award
    SASAKI Ryohei

  • Oct. 2022 Kobe University, President award

  • Oct. 2021 Kobe University, President award

  • Oct. 2020 Kobe University, President award

  • Oct. 2019 Kobe University, President award

  • Oct. 2018 Kobe University, President award

  • Apr. 2014 日本医学放射線学会, 日本医学放射線学会 CyPos賞 Platinum Medal, Space making radiotherapy: Safety and efficacy of absorbable Spacer in Particle Therapy
    Sasaki Ryohei, H.Akasaka, D.Miyawaki, NORSHAZRINASULAIMAN, Y.Demizu, S.Yamada, M.Murakami, T.Fukumoto
    Japan society

  • Jul. 2012 Takahashi memorial Symposium & The 6th Japan-US Cancer Therapy, Excellent Poster Presentation Award, The 6th Takahashi memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium,
    KUehara, TSasayama, Sasaki Ryohei
    International society

  • Apr. 2012 日本医学放射線学会, 優秀論文賞, Multi-institutional Analysis of Solitary Extramedullary Plasmacytoma of the Head and Neck Treated With Curative Radiotherapy. Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):626-34
    Sasaki Ryohei
    Japan society

  • Oct. 2008 第45回日本癌治療学会, 日本癌治療学会優秀発表賞, 早期喉頭癌(T1-T2N0M0)の局所制御におけるNF-κB発現の検討 他の生物学的マーカーとの比較.
    Nishimura Hideki, Sasaki Ryohei

  • Oct. 2001 American Scociety of Therapeutic Radiation Oncology, Resident Awards of American Society of Therapeutic Radiation Oncology, Basic Science
    Sasaki Ryohei

  • Nov. 1998 日本放射線腫瘍学会, 日本放射線腫瘍学会会長賞, 研究発表
    Sasaki Ryohei

■ Paper
  • Yasuyuki Shimizu, Shunta Hirano, Mohammed Salah, Namiko Hoshi, Yoko Yamashita, Takeshi Fukumoto, Naritoshi Mukumoto, Ai Nakaoka, Takeaki Ishihara, Daisuke Miyawaki, Hitoshi Ashida, Ryohei Sasaki
    Background: Proanthocyanidins (PACs) from black soybean seed coat have antioxidant and anti-tumorigenic properties. We investigated the anti-tumor properties and mechanisms of action of PACs on colorectal cancer (CRC). Methods: We fed the APCmin/+ mice, which are highly susceptible to spontaneous intestinal adenoma formation, diets supplemented with or without PACs for 7 weeks and assessed adverse effects, the number and size of intestinal polyps, and the expression of pro- and anti-proliferative proteins in the intestine. The mouse gut microbiome composition was analyzed, and the concentrations of gut short-chain fatty acids (SCFAs) were quantified. We also compared CRC incidence in Tamba in Japan, where black soybean is consumed frequently, with that in the rest of Japan. Results: The number and size of intestinal polyps notably decreased in the PAC-fed mice. Compared with control mice, the PAC-fed mice showed lower expression of proliferation markers proliferating cell nuclear antigen and β catenin and a higher expression of the anti-inflammatory protein oligomeric mucus gel-forming. PAC supplementation increased the prevalence and concentrations of beneficial gut microbes and SCFAs, respectively. Conclusions: Diet supplemented with black soybean-derived PACs could prevent CRC development in mice through gut microbiome remodeling. Regions consuming black soybeans have low CRC incidence. Notably, the incidence of CRC, breast cancer, and liver cancer was significantly lower in Tamba than in the rest of Hyogo Prefecture or Japan. Future studies should delineate the mechanisms underlying the CRC-protective effects of PACs. Nevertheless, our results demonstrate the potential of including PACs in dietary recommendations for cancer prevention.
    MDPI AG, Nov. 2024, Cancers, 16(22) (22), 3846 - 3846
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Peter J K Tokuda, Yusuke Demizu, Tianyuan Wang, Nobuyoshi Fukumitsu, Takeshi Suzuki, Sho Kurihara, Eiso Hiyama, Shuhei Karakawa, Yoshiyuki Kosaka, Ryohei Sasaki, Takumi Fukumoto, Masaki Kokubo, Toshinori Soejima
    Space-making particle therapy, which consists of surgical placement of a spacer followed by particle therapy, has become a solution to the problem of normal organs being exposed to a high radiation dose. A bioabsorbable spacer is particularly suitable for this purpose, but is not widely used. Surgical placement of a spacer is performed mostly to protect the digestive tract, but can also be used to protect the kidneys. Therefore, we have been interested in the use of space-making particle therapy to preserve renal function. A 14 month-old boy with intermediate-risk retroperitoneal rhabdomyosarcoma underwent surgery with placement of a bioabsorbable spacer following neoadjuvant chemotherapy and then received proton beam therapy of 41.4 Gy (relative biological effectiveness) in 23 fractions. In the 41 months since PBT, he has survived without local recurrence or signs of renal impairment. This report describes the first-ever case of surgical placement of a bioabsorbable spacer with the aim of preserving renal function during proton beam therapy. Space-making particle therapy is an innovative solution for peritoneal tumors adjacent to the kidneys.
    Oct. 2024, International cancer conference journal, 13(4) (4), 476 - 480, English, International magazine
    Scientific journal

  • Yusuke Tsuzuki, Michi Kamei, Hiromitsu Iwata, Risa Takeda, Hiroaki Kimura, Hisaki Aiba, Takayuki Murase, Takahiro Tsuchiya, Ryohei Sasaki, Akio Hiwatashi
    In radiotherapy for pediatric abdominal tumors, determining the effect of concurrent chemotherapy on polyglycolic acid (PGA) spacers is crucial; yet this effect has not been validated. Therefore, we aimed to evaluate the impact of cyclophosphamide (CPA) chemotherapy on the PGA spacer using a rat model. Twenty-four rats were implanted with the spacer, and morphological changes in the spacer were assessed on CT for both the CPA-dosed group (40 mg/kg) and the control group. The size and volume of the spacer were quantified using CT, while the degree of adhesion and microscopic examination of the tissue were determined using pathology specimens. Morphologically, the size of the spacer decreased over time in both the CPA-dosed and control groups, with no significant differences observed between groups. No significant differences in adhesion were observed between the two groups. Macrophages were observed around the PGA fibers, suggesting their involvement in the degradation of the PGA spacer. These results suggest that CPA does not cause significant clinically problematic degradation or adverse tissue reactions to the PGA spacer. This study reinforced the benefits of PGA spacers; however, future research focusing on in vivo longitudinal monitoring of individual rats, as well as on humans, is required.
    Sep. 2024, Journal of Radiation Research, English, International magazine
    [Refereed]
    Scientific journal

  • Akihiro Fujisawa, Shohei Komatsu, Satoshi Omiya, Ryosuke Fujinaka, Nobuaki Yamasaki, Hiroaki Yanagimoto, Masahiro Kido, Hirochika Toyama, Ryohei Sasaki, Takumi Fukumoto
    BACKGROUND/AIM: Neskeep®, an absorbable polyglycolic acid spacer, has been developed as the optimal material for spacer placement surgery. However, preventing its severe adhesion is a crucial concern. Therefore, we aimed to identify an effective anti-adhesion agent for Neskeep® using rat models. MATERIALS AND METHODS: Animal experiments were performed using 60 rats, which underwent Neskeep® placement on the abdominal wall. Three types of anti-adhesion agents were employed, establishing four subgroups: Seprafilm®, INTERCEED®, AdSpray®, and only Neskeep® (control) groups. Rats were sacrificed on postoperative days 7, 14, and 28 to assess adhesion levels around the Neskeep® Macroscopic visual assessment with the Lauder score and histopathological evaluation were performed to assess the degree of adhesion. RESULTS: There were no significant differences in the proportion of Lauder scores on days 7 and 14 between the four groups. Histological evaluation revealed no significant differences between groups at any observation time. However, the mean Lauder scores at day 28 were 5.0, 1.6, 4.0, and 4.8 in the Neskeep®, Seprafilm®, INTERCEED®, and AdSpray® groups, respectively. The proportion of milder Lauder score was significantly higher in the Seprafilm® group on day 28. CONCLUSION: Seprafilm® may exhibit an anti-adhesive effect when used with Neskeep®.
    Aug. 2024, Anticancer research, 44(8) (8), 3349 - 3353, English, International magazine
    Scientific journal

  • Toshiyuki Takemori, Hitomi Hara, Teruya Kawamoto, Naomasa Fukase, Ryoko Sawada, Shuichi Fujiwara, Ikuo Fujita, Takuya Fujimoto, Masayuki Morishita, Shunsuke Yahiro, Tomohiro Miyamoto, Masanori Saito, Jun Sugaya, Katsuhiro Hayashi, Hiroyuki Kawashima, Tomoaki Torigoe, Tomoki Nakamura, Hiroya Kondo, Toru Wakamatsu, Munenori Watanuki, Munehisa Kito, Satoshi Tsukushi, Akihito Nagano, Hidetatsu Outani, Shunichi Toki, Shunji Nishimura, Hiroshi Kobayashi, Itsuo Watanabe, Yusuke Demizu, Ryohei Sasaki, Takumi Fukumoto, Tomoyuki Matsumoto, Ryosuke Kuorda, Toshihiro Akisue
    BACKGROUND: Few studies have compared the clinical outcomes of patients with pelvic bone sarcomas treated surgically and those treated with particle beam therapy. This is a multicenter retrospective cohort study which compared the clinical outcomes of patients with pelvic bone sarcoma who underwent surgical treatment and particle beam therapy in Japan. METHODS: A total of 116 patients with pelvic bone sarcoma treated at 19 specialized sarcoma centers in Japan were included in this study. Fifty-seven patients underwent surgery (surgery group), and 59 patients underwent particle beam therapy (particle beam group; carbon-ion radiotherapy: 55 patients, proton: four patients). RESULTS: The median age at primary tumor diagnosis was 52 years in the surgery group and 66 years in the particle beam group (P < 0.001), and the median tumor size was 9 cm in the surgery group and 8 cm in the particle beam group (P = 0.091). Overall survival (OS), local control (LC), and metastasis-free survival (MFS) rates were evaluated using the Kaplan-Meier method and compared among 116 patients with bone sarcoma (surgery group, 57 patients; particle beam group, 59 patients). After propensity score matching, the 3-year OS, LC, and MFS rates were 82.9% (95% confidence interval [CI], 60.5-93.2%), 66.0% (95% CI, 43.3-81.3%), and 78.4% (95% CI, 55.5-90.5%), respectively, in the surgery group and 64.9% (95% CI, 41.7-80.8%), 86.4% (95% CI, 63.3-95.4%), and 62.6% (95% CI, 38.5-79.4%), respectively, in the particle beam group. In chordoma patients, only surgery was significantly correlated with worse LC in the univariate analysis. CONCLUSIONS: The groups had no significant differences in the OS, LC, and MFS rates. Among the patients with chordomas, the 3-year LC rate in the particle beam group was significantly higher than in the surgery group.
    Jul. 2024, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, English, Domestic magazine
    Scientific journal

  • Mitsuko Yui, Yoshihisa Matsuno, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Naomi Kiyota, Tadashi Nomura, Daisuke Miyawaki, Ryohei Sasaki, Ken-Ichi Nibu
    Background Since the larynx and pharynx are vital for respiration, swallowing, and speech, chemoradiotherapy (CRT) has been widely applied for T3 hypopharyngeal cancer (HPC) as an organ-preserving treatment. However, CRT can lead to severe late adverse events such as dysphagia and aspiration pneumonia, especially in patients who have difficulty swallowing and/or aspiration at the time of initial diagnosis. Patients and methods Between 2012 and 2020, 86 patients with T3 HPC treated with curative intent at Kobe University Hospital were included in this study. The average age was 69 years old, ranging from 43 to 89. Diseases were classified as Stage III in 29 patients, Stage IVA in 52 patients, and Stage IVB in five patients. Thirty-five (41%) patients were treated by CRT, and 51 (59%) patients were treated by surgery. Patients were followed up for at least two years, and the follow-up period ranged from four to 128 months (median: 45 months). Results Three-year progression-free survival (PFS) rates of patients treated by CRT and patients treated by surgery were 56.2% and 60.3%, respectively. Three-year disease-specific survival (DSS) rates of patients treated by CRT and surgically treated patients were 79.0% vs. 70.8%, respectively. Three-year overall survival (OS) rates of patients treated by CRT and surgically treated patients were 64.5% and 69.0%, respectively. Of note, a significant difference was observed between three-year DSS and three-year PFS (79.0% vs. 56.2%, p = 0.0014) in the patients treated by CRT but not in the patients treated by surgery. Conclusions No significant differences were observed between the PFS, DSS, and OS rates of patients treated by CRT and those of surgically treated patients. Locoregional recurrences after CRT were significantly successfully salvaged by surgical intervention. These results suggest that CRT can be applied as an alternative to surgery without reducing survival, especially for patients without severe clinical symptoms. Meticulous follow-up is mandatory for early detection of recurrence to salvage by surgery and for the management of late adverse events.
    Jun. 2024, Cureus, 16(6) (6), e62553, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 大片 祐一, 小松 昇平, 出水 祐介, 山本 暢之, 佐々木 良平, 福本 巧, 尾藤 祐子
    (一社)日本小児血液・がん学会, Mar. 2024, 日本小児血液・がん学会雑誌, 60(5) (5), 297 - 300, Japanese

  • 大片 祐一, 小松 昇平, 出水 祐介, 山本 暢之, 佐々木 良平, 福本 巧, 尾藤 祐子
    (一社)日本小児血液・がん学会, Mar. 2024, 日本小児血液・がん学会雑誌, 60(5) (5), 297 - 300, Japanese

  • Daisuke Kawahara, Yuji Murakami, Shota Awane, Yuki Emoto, Kazuma Iwashita, Hikaru Kubota, Ryohei Sasaki, Yasushi Nagata
    OBJECTIVES: To develop a multi-institutional prediction model to estimate the local response to oesophageal squamous cell carcinoma (ESCC) treated with definitive radiotherapy based on radiomics and dosiomics features. METHODS: The local responses were categorised into two groups (incomplete and complete). An external validation model and a hybrid model that the patients from two institutions were mixed randomly were proposed. The ESCC patients at stages I-IV who underwent chemoradiotherapy from 2012 to 2017 and had follow-up duration of more than 5 years were included. The patients who received palliative or pre-operable radiotherapy and had no FDG PET images were excluded. The segmentations included the GTV, CTV, and PTV which are used in treatment planning. In addition, shrinkage, expansion, and shell regions were created. Radiomic and dosiomic features were extracted from CT, FDG PET images, and dose distribution. Machine learning-based prediction models were developed using decision tree, support vector machine, k-nearest neighbour (kNN) algorithm, and neural network (NN) classifiers. RESULTS: A total of 116 and 26 patients enrolled at Centre 1 and Centre 2, respectively. The external validation model exhibited the highest accuracy with 65.4% for CT-based radiomics, 77.9% for PET-based radiomics, and 72.1% for dosiomics based on the NN classifiers. The hybrid model exhibited the highest accuracy of 84.4% for CT-based radiomics based on the kNN classifier, 86.0% for PET-based radiomics, and 79.0% for dosiomics based on the NN classifiers. CONCLUSION: The proposed hybrid model exhibited promising predictive performance for the local response to definitive radiotherapy in ESCC patients. CLINICAL RELEVANCE STATEMENT: The prediction of the complete response for oesophageal cancer patients may contribute to improving overall survival. The hybrid model has the potential to improve prediction performance than the external validation model that was conventionally proposed. KEY POINTS: • Radiomics and dosiomics used to predict response in patients with oesophageal cancer receiving definitive radiotherapy. • Hybrid model with neural network classifier of PET-based radiomics improved prediction accuracy by 8.1%. • The hybrid model has the potential to improve prediction performance.
    Feb. 2024, European radiology, 34(2) (2), 1200 - 1209, English, International magazine
    Scientific journal

  • Yasuyuki Kajimoto, Hirotaka Shinomiya, Natsumi Uehara, Masanori Teshima, Takeshi Fujita, Akinobu Kakigi, Yoshinori Imamura, Naomi Kiyota, Daisuke Miyawaki, Ryohei Sasaki, Hidehito Kimura, Ken-Ichi Nibu
    The expression of EGFR and p16 in the external auditory canal squamous cell carcinoma (EACSCC) and their impacts on oncological outcomes were not well studied. Seventeen-one consecutive patients who were treated for EACSCC at Kobe University Hospital from 1995 to 2018 were enrolled in this study. The expression of EGFR, and p16 were evaluated and their impacts on oncological outcomes were statistically analyzed. Positive expression of EGFR was observed in 62 patients (87%). Strong positive expression of p16 were observed in 18 patients (32.4%), and weakly positive expression in 30 patients (42.3%), respectively. While the number of the patients with negative EGFR expression were limited, all the surgically treated patients with negative EGFR expression have been alive without disease. In the patients with T3 & T4a EACSCC, prognosis of the patients with positive p16 expression EACSCC tended to be better than those with negative p16 expression. These results suggest the clinical significance of EGFR and p16 expressions in the patients with advanced EACSCC to predict oncological outcomes.
    Jan. 2024, The Kobe journal of medical sciences, 69(4) (4), E144-E150, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takumi Sato, Yasumasa Kakei, Takumi Hasegawa, Masahiko Kashin, Shun Teraoka, Akinobu Yamaguchi, Ryohei Sasaki, Masaya Akashi
    Introduction: Head and neck squamous cell carcinoma (HNSCC) treatment includes surgery, radiotherapy, and immunotherapy with the aim of eradicating cancer cells without affecting normal tissues. HNSCC expresses epidermal growth factor receptor (EGFR) and cetuximab, an IgG1 monoclonal antibody targeting epidermal growth factor receptor, has been approved for the treatment of HNSCC. However, cetuximab has low reactivity and induces serious side effects. Gold nanoparticles (AuNPs) were reported to enhance the local antitumor effects of radiotherapy without damaging normal cells. Methods and Results: This study investigated the in vitro effects of single and combination therapy with AuNPs (1.0 nM), cetuximab (30 nM), and radiotherapy (4 Gy) on a human HNSCC cell line, HSC-3. Combination treatment of AuNPs + cetuximab + radiotherapy markedly reduced HSC-3 numbers and proliferation and enhanced apoptosis compared with single and double combination treatments. Furthermore, the in vivo combination treatment (AuNPs + cetuximab + radiotherapy) of a xenograft model of HSC-3 cells transplanted into nude mice (BALB/cAJcl-nu/nu) reduced the tumor volume compared with the controls. Scanning electron microscopy demonstrated the presence of AuNPs in tumor tissues and toxicity analysis indicated that AuNPs had no toxic effect on normal tissues. Conclusions: This study showed that AuNPs alone do not have a tumor-suppressing effect, but they sensitize tumors to radiotherapy and bind to cetuximab, leading to enhanced antitumor effects.
    MDPI AG, Dec. 2023, Cancers, 15(23) (23), 5697 - 5697, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Shohei Komatsu, Tianyuan Wang, Kazuki Terashima, Yusuke Demizu, Makoto Anzai, Masaki Suga, Tomohiro Yamashita, Osamu Suzuki, Tomoaki Okimoto, Ryohei Sasaki, Takumi Fukumoto
    BACKGROUND: Particle therapy (PT) has favorable dose distribution and high curability. However, radiotherapy for malignant tumors adjacent to the gastrointestinal tract is contraindicated owing to its low tolerance. To overcome this, combination treatment with surgery to make a space between the tumor and adjacent gastrointestinal tract followed by PT has been developed. Several materials have been used for the spacer, and we have recently developed the absorbable polyglycolic acid (PGA) spacer, which has been used since 2019. This study is the first report of consecutive case series of spacer placement surgery using the PGA spacer. STUDY DESIGN: Fifty consecutive patients undergoing spacer placement surgery with the PGA spacer were evaluated. Postoperative laboratory data, morbidity related to the treatment, and spacer volume after treatment were evaluated. RESULTS: There were no treatment-related deaths, and all but two patients completed combination treatment. The median ratios of post-operative PGA spacer volume to the pre-treatment volume were 96.9%, 87.7%, and 74.6% at weeks 2, 4, and 8, respectively. The spacer volume was maintained at 80% at 7 weeks and was predicted to be 50% at 15 weeks and 20% in 24 weeks. CONCLUSIONS: Spacer placement surgery using the PGA spacer was feasible and tolerable. The PGA spacers maintained sufficient thickness during the duration of subsequent PT. Combination treatment using the PGA spacer is innovative and has the potential to become a new standard curative local treatment.
    Sep. 2023, Journal of the American College of Surgeons, 238(1) (1), 119 - 128, English, International magazine
    Scientific journal

  • Tianyuan Wang, Keitaro Sofue, Ryuji Shimada, Takeaki Ishihara, Ryuichi Yada, Masanori Miyamoto, Ryohei Sasaki, Takamichi Murakami
    To develop and investigate the feasibility of sub-second temporal resolution volumetric T1-weighted four-dimensional (4D-) MRI in comparison with 4D-CT for respiratory-correlated motion assessment using an MRI/CT-compatible phantom. Sub-second high temporal resolution (0.5 s) gradient-echo T1-weighted 4D-MRI was developed using a volumetric acquisition scheme with compressed sensing. An MRI/CT-compatible motion phantom (simulated liver tumor) with three sinusoidal movements of amplitudes and two respiratory patterns was introduced and imaged with 4D-MRI and 4D-CT to investigate the geometric accuracy of the target movement. The geometric accuracy, including centroid position, volume, similarity index of dice similarity coefficient (DSC), and Hausdorff distance (HD), was systematically evaluated. Proposed 4D-MRI achieved a similar geometric accuracy compared with 4D-CT regarding the centroid position, volume, and similarity index. The observed position differences of the absolute average centroid were within 0.08 cm in 4D-MRI and 0.03 cm in 4D-CT, less than the 1-pixel resolution for each modality. The observed volume difference in 4D-MRI/4D-CT was within 0.73 cm3 (4.5%)/0.29 cm3 (2.1%) for a large target and 0.06 cm3 (11.3%)/0.04 cm3 (11.6%) for a small target. The observed DSC values for 4D-MRI/4D-CT were at least 0.93/0.95 for the large target and 0.83/0.84 for the small target. The maximum HD values were 0.25 cm/0.31 cm for the large target and 0.21 cm/0.15 cm for the small target. Although 4D-CT potentially exhibit superior numerical accuracy in phantom studies, the proposed high temporal resolution 4D-MRI demonstrates sub-millimetre geometric accuracy comparable to that of 4D-CT. These findings suggest that the 4D-MRI technique is a viable option for characterizing motion and generating phase-dependent internal target volumes within the realm of radiotherapy.
    Sep. 2023, Scientific reports, 13(1) (1), 15685 - 15685, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Akihiro Yamada, Hirotaka Shinomiya, Natsumi Uehara, Keisuke Iritani, Shun Tatehara, Tatsuya Furukawa, Masanori Teshima, Daisuke Miyawaki, Takeshi Fujita, Akinobu Kakigi, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu
    BACKGROUND: Squamous cell carcinoma of the external auditory canal (EACSCC) is a rare condition. However, a standard treatment has not yet been established. We retrospectively evaluated the efficacy, adverse events, and feasibility of TPF-CCRT (concomitant chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil) in patients with advanced EACSCC. METHODS: Thirty-five consecutive patients with advanced EACSCC (T3, T4) initially treated with TPF-CCRT at Kobe University Hospital were included. T4 diseases with invasion of the brain, internal carotid artery, or internal jugular vein were classified as T4b, and those without these features were classified as T4a. RESULTS: Five-year overall survival rates for T3 and T4 were 100% and 64.2%, respectively. A significant difference was observed between T4a and T4b (82.4% vs. 30%, p = 0.007). Five-year progression-free survival rates of T3, T4a, and T4b were 100%, 68%, and 20% (p = 0.022), respectively. CONCLUSIONS: TPF-CCRT should be considered as a plausible treatment option for advanced EACSCC.
    Jul. 2023, Head & neck, 45(10) (10), 2498 - 2504, English, International magazine
    Scientific journal

  • Kazuhiro Kitajima, Junpei Kuyama, Takashi Kawahara, Tsuyoshi Suga, Tomoaki Otani, Shigeyasu Sugawara, Yumiko Kono, Yukihisa Tamaki, Ayumi Seko-Nitta, Yoshinobu Ishiwata, Kimiteru Ito, Akira Toriihara, Shiro Watanabe, Makoto Hosono, Hideaki Miyake, Shingo Yamamoto, Ryohei Sasaki, Mitsuhiro Narita, Koichiro Yamakado
    To evaluate the usefulness of change in the automated bone scan index (aBSI) value derived from bone scintigraphy findings as an imaging biomarker for the assessment of treatment response and survival prediction in metastatic castration-resistant prostate cancer (mCRPC) patients treated with Ra-223. This study was a retrospective investigation of a Japanese cohort of 205 mCRPC patients who received Ra-223 in 14 hospitals between July 2016 and August 2020 and for whom bone scintigraphy before and after radium-223 treatment was available. Correlations of aBSI change, with changes in the serum markers alkaline phosphatase (ALP) and prostate-specific antigen (PSA) were evaluated. Additionally, the association of those changes with overall survival (OS) was assessed using the Cox proportional-hazards model and Kaplan–Meier curve results. Of the 205 patients enrolled, 165 (80.5%) completed six cycles of Ra-223. Following treatment, ALP decline (%ALP < 0%) was noted in 72.2% (148/205), aBSI decline (%aBSI < 0%) in 52.7% (108/205), and PSA decline (%PSA < 0%) in 27.8% (57/205). Furthermore, a reduction in both aBSI and ALP was seen in 87 (42.4%), a reduction in only ALP was seen in 61 (29.8%), a reduction in only aBSI was seen in 21 (10.2%), and in both aBSI and ALP increasing/stable (≥0%) was seen in 36 (17.6%) patients. Multiparametric analysis showed changes in PSA [hazard ratio (HR) 4.30, 95% confidence interval (CI) 2.32–8.77, p < 0.0001], aBSI (HR 2.22, 95%CI 1.43–3.59, p = 0.0003), and ALP (HR 2.06, 95%CI 1.35–3.14, p = 0.0008) as significant prognostic factors for OS. For mCRPC patients treated with Ra-223, aBSI change is useful as an imaging biomarker for treatment response assessment and survival prediction.
    MDPI AG, May 2023, Cancers, 15(10) (10), 2784 - 2784
    Scientific journal

  • Kotaro Tamagawa, Hirotaka Shinomiya, Takuya Okada, Shun Tatehara, Masanori Teshima, Ryohei Sasaki, Ken-Ichi Nibu
    BACKGROUND: Superselective cisplatin (CDDP) infusion via the external carotid artery system and concomitant radiotherapy (RADPLAT) provides favorable oncological and functional outcomes in patients with maxillary sinus cancer. However, targeted lesions are occasionally fed by the branch of the internal carotid artery. METHODS: In RADPLAT for maxillary sinus cancer partly fed by the ophthalmic artery, the ethmoid arteries were ligated in two patients without medial orbital wall involvement. In four patients with that, CDDP was administered via the ophthalmic artery. RESULTS: A complete response was obtained in all six patients. Locoregional recurrence was not observed in any cases. However, visual acuity was lost in four patients who received the ophthalmic artery infusion. CONCLUSIONS: Ligation of the ethmoid arteries is recommended in RADPLAT for maxillary sinus cancer with lesions fed by the ophthalmic artery. CDDP administered via the ophthalmic artery may be considered if a patient accepts the possibility of visual loss.
    May 2023, Head & neck, 45(5) (5), E16-E24, English, International magazine

  • 当院における甲状腺がんに対するがん遺伝子パネル検査の現状と課題
    小山 泰司, 清田 尚臣, 今村 善宣, 長谷 善明, 下田 光, 手島 直則, 四宮 弘隆, 宮脇 大輔, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 132 - 132, Japanese

  • 進行頭頸部扁平上皮がん患者における静脈血栓塞栓症 前向き観察研究サブ解析
    今村 善宣, 小山 泰司, 長谷 善明, 手島 直則, 四宮 弘隆, 宮脇 大輔, 佐々木 良平, 丹生 健一, 清田 尚臣
    (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 152 - 152, Japanese

  • Kazuma Iwashita, Hikaru Kubota, Riku Nishioka, Yuki Emoto, Daisuke Kawahara, Takeaki Ishihara, Daisuke Miyawaki, Ikuno Nishibuchi, Yasushi Nagata, Ryohei Sasaki
    BACKGROUND/AIM: Sarcopenia is an independent survival predictor in several tumor types. Computed tomography (CT) is the standard measurement for body composition assessment. Radiomics analysis of CT images allows for the precise evaluation of skeletal muscles. This study aimed to construct a prognostic survival model for patients with esophageal cancer who underwent radical irradiation using skeletal muscle radiomics. PATIENTS AND METHODS: We retrospectively identified patients with esophageal cancer who underwent radical irradiation at our institution between April 2008 and December 2017. Skeletal muscle radiomics were extracted from an axial pretreatment CT at the third lumbar vertebral level. The prediction model was constructed using machine learning coupled with the least absolute shrinkage and selection operator (LASSO). The predictive nomogram model comprised clinical factors with radiomic features. Three prediction models were created: clinical, radiomics, and combined. RESULTS: Ninety-eight patients with 98 esophageal cancers were enrolled in this study. The median observation period was 57.5 months (range=1-98 months). Thirty-five radiomics features were selected by LASSO analysis, and a prediction model was constructed using training and validation data. The average of the accuracy, specificity, sensitivity, and area under the concentration-time curve for predicting survival in esophageal cancer in the combined model were 75%, 92%, and 0.86, respectively. The C-indices of the clinical, radiomics, and combined models were 0.76, 0.80, and 0.88, respectively. CONCLUSION: A prediction model with skeletal muscle radiomics and clinical data might help determine survival outcomes in patients with esophageal cancer treated with radical radiotherapy.
    Apr. 2023, Anticancer research, 43(4) (4), 1749 - 1760, English, International magazine
    Scientific journal

  • Dual Energy MV-CBCTを用いた照合画像の画質改善の検討
    平野 駿太, 椋本 成俊, 中岡 藍, 清水 康之, 江本 裕樹, 小林 加奈, 石原 武明, 宮脇 大輔, 佐々木 良平, 西谷 隆治
    (公社)日本医学放射線学会, Feb. 2023, Japanese Journal of Radiology, 41(Suppl.) (Suppl.), 30 - 30, Japanese

  • Hirofumi Iwahashi, Hiroaki Nagashima, Kazuhiro Tanaka, Takiko Uno, Mitsuru Hashiguchi, Masahiro Maeyama, Yuichiro Somiya, Masato Komatsu, Takanori Hirose, Tomoo Itoh, Ryohei Sasaki, Takashi Sasayama
    OBJECTIVE: Adult brainstem gliomas (BSGs) are rare tumors of the CNS that are poorly understood. Upregulation of the oncometabolite 2-hydroxyglutarate (2HG) in the tumor indicates the mutation of isocitrate dehydrogenase (IDH), which can be detected by magnetic resonance spectroscopy (MRS). Although histological examination is required for the definitive diagnosis of BSG, 2HG-optimized MRS (2HG-MRS) may be useful, considering the difficult nature of brainstem lesion biopsy. The aim of this study was to evaluate the utility of 2HG-MRS for diagnosing IDH-mutant adult BSG. METHODS: Patients with a radiographically confirmed brainstem tumor underwent 3T MRS. A single voxel was set in the lesion with reference to the T2 or fluid-attenuated inversion recovery image and analyzed according to the 2HG-tailored MRS protocol (point-resolved spectroscopic sequence; echo time 35 msec). All patients underwent intraoperative navigation-guided or CT-guided stereotactic biopsy for histopathological diagnosis. The status of IDH and H3K27M mutations was confirmed by immunohistochemistry and direct DNA sequencing. In addition, the authors examined the relationship between patients' 2HG concentrations and survival time. RESULTS: Ten patients (7 men, 3 women; median age 33.5 years) underwent 2HG-MRS and biopsy. Four patients had an H3K27M mutation and 4 had an IDH1 mutation (1 R132H canonical IDH mutation, 2 R132S and 1 R132G noncanonical IDH mutations). Two had neither H3K27M nor IDH mutations. The H3K27M and IDH mutations were mutually exclusive. Most tumors were located in the pons. There was no significant radiological difference between mutant H3K27M and IDH on a conventional MRI sequence. A 2HG concentration ≥ 1.8 mM on MRS demonstrated 100% (95% CI 28%-100%) sensitivity and 100% (95% CI 42%-100%) specificity for IDH-mutant BSG (p = 0.0048). The median overall survival was 10 months in IDH-wild-type BSG patients (n = 6) and could not be estimated in IDH-mutant BSG patients (n = 4) due to the small number of deaths (p = 0.008). CONCLUSIONS: 2HG-MRS demonstrated high sensitivity and specificity for the prediction of IDH-mutant BSG. In addition, 2HG-MRS may be useful for predicting the prognosis of adult BSG patients.
    Jan. 2023, Journal of neurosurgery, 1 - 8, English, International magazine
    Scientific journal

  • ラットモデルによるポリグリコール酸製吸収スペーサーの化学療法による影響の検討
    亀井 美智, 都築 侑介, 岩田 宏満, 木村 浩明, 相羽 久輝, 武田 理沙, 高木 大輔, 村瀬 貴幸, 荻野 浩幸, 佐々木 良平
    (一社)日本小児血液・がん学会, Oct. 2022, 日本小児血液・がん学会雑誌, 59(4) (4), 309 - 309, Japanese

  • 小児がん支持療法と関連する外科治療 吸収性スペーサー留置術 神戸大学での経験
    大片 祐一, 小松 昇平, 尾藤 祐子, 佐々木 良平, 福本 巧
    (一社)日本小児血液・がん学会, Oct. 2022, 日本小児血液・がん学会雑誌, 59(4) (4), 163 - 163, Japanese

  • ラットモデルによるポリグリコール酸製吸収スペーサーの化学療法による影響の検討
    亀井 美智, 都築 侑介, 岩田 宏満, 木村 浩明, 相羽 久輝, 武田 理沙, 高木 大輔, 村瀬 貴幸, 荻野 浩幸, 佐々木 良平
    (一社)日本小児血液・がん学会, Oct. 2022, 日本小児血液・がん学会雑誌, 59(4) (4), 309 - 309, Japanese

  • Toshiyuki Takemori, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Shuichi Fujiwara, Ikuo Fujita, Takuya Fujimoto, Masayuki Morishita, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Masanori Saito, Jun Sugaya, Katsuhiro Hayashi, Hiroyuki Kawashima, Tomoaki Torigoe, Tomoki Nakamura, Hiroya Kondo, Toru Wakamatsu, Munenori Watanuki, Munehisa Kito, Satoshi Tsukushi, Akihito Nagano, Hidetatsu Outani, Shunichi Toki, Shunji Nishimura, Hiroshi Kobayashi, Itsuo Watanabe, Yusuke Demizu, Ryohei Sasaki, Takumi Fukumoto, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue
    This study aimed to retrospectively analyze the clinical outcomes of patients with pelvic and retroperitoneal bone and soft tissue sarcoma (BSTS). Overall, 187 patients with BSTS in the pelvis and retroperitoneal region treated at 19 specialized sarcoma centers in Japan were included. The prognostic factors related to overall survival (OS), local control (LC), and progression-free survival (PFS) were evaluated. The 3-year OS and LC rates in the 187 patients were 71.7% and 79.1%, respectively. The 3-year PFS in 166 patients without any distant metastases at the time of primary tumor diagnosis was 48.6%. Osteosarcoma showed significantly worse OS and PFS than other sarcomas of the pelvis and retroperitoneum. In the univariate analyses, larger primary tumor size, soft tissue tumor, distant metastasis at the time of primary tumor diagnosis, P2 location, chemotherapy, and osteosarcoma were poor prognostic factors correlated with OS. Larger primary tumor size, higher age, soft tissue tumor, chemotherapy, and osteosarcoma were poor prognostic factors correlated with PFS in patients without any metastasis at the initial presentation. Larger primary tumor size was the only poor prognostic factor correlation with LC. This study has clarified the epidemiology and prognosis of patients with pelvic and retroperitoneal BSTS in Japan.
    Jun. 2022, Cancers, 14(12) (12), English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiroaki Akasaka, Kazufusa Mizonobe, Yuya Oki, Kazuyuki Uehara, Masao Nakayama, Shuhei Tamura, Yoshiki Munetomo, Haruna Kawaguchi, Jun Ishida, Aya Harada, Takeaki Ishihara, Hikaru Kubota, Hiroki Kawaguchi, Ryohei Sasaki, Hiroshi Mayahara
    PURPOSE: Real-time tracking systems of moving respiratory targets such as CyberKnife, Radixact, or Vero4DRT are an advanced robotic radiotherapy device used to deliver stereotactic body radiotherapy (SBRT). The internal target volume (ITV) of lung tumors is assessed through a fiducial marker fusion using four-dimensional computed tomography (CT). It is important to minimize the ITV to protect normal lung tissue from exposure to radiation and the associated side effects post SBRT. However, the ITV may alter if there is a change in the position of the fiducial marker with respect to the tumor. This study investigated the relationship between fiducial marker position and the ITV in order to prevent radiation exposure of normal lung tissue, and correct target coverage. MATERIALS AND METHODS: This study retrospectively reviewed 230 lung cancer patients who received a fiducial marker for SBRT between April 2015 and September 2021. The distance of the fiducial marker to the gross tumor volume (GTV) in the expiratory (dex ) and inspiratory (din ) CT, and the ratio of the ITV/V(GTVex ), were investigated. RESULTS: Upon comparing each lobe, although there was no significant difference in the ddiff and the ITV/V(GTVex ) between all lobes for dex  < 10 mm, there was significant difference in the ddiff and the ITV/V(GTVex ) between the lower and upper lobes for dex ≥ 10 mm (p < 0.05). Moreover, there was significant difference in the ddiff and the ITV/V(GTVex ) between dex ≥10 mm and dex  < 10 mm in all lung regions (p < 0.05). CONCLUSION: The ITV that had no margin from GTVs increased when dex was ≥10 mm for all lung regions (p < 0.05). Furthermore, the increase in ITV tended to be greater in the lower lung lobe. These findings can help decrease the possibility of adverse events post SBRT, and correct target coverage.
    Jun. 2022, Journal of applied clinical medical physics, 23(6) (6), e13596, English, International magazine
    Scientific journal

  • Hirokazu Komatsu, Tatsuya Furukawa, Keisuke Iritani, Shun Tatehara, Miki Takahashi, Shinobu Iwaki, Yasumasa Kakei, Takumi Hasegawa, Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Kazunobu Hashikawa, Naomi Kiyota, Ryohei Sasaki, Masaya Akashi, Ken-Ichi Nibu
    OBJECTIVE: The blowing time ratio, which is the ratio of the blowing time when the nostrils are open and closed, is significantly correlated with velopharyngeal pressure, not only during speech but also during swallowing. This study aimed to further evaluate the usefulness of the blowing time ratio as a screening tool to evaluate the swallowing pressure of patients treated for oral and oropharyngeal cancers using high-resolution manometery (HRM). METHODS: Ten patients treated for oral or oropharyngeal cancer were recruited for this study. Swallowing pressures at the velopharynx, oropharynx, and upper esophageal sphincter (UES) were measured using HRM. Their correlations with the blowing time ratio were analyzed. RESULTS: The blowing time ratio was significantly correlated with the swallowing pressures of the oropharynx (CC = 0.815, p = 0.004) and the velopharynx (CC = 0.657, p = 0.039), but not of the UES. CONCLUSIONS: The present results further support our previous finding that the blowing time ratio is a useful screening tool to evaluate velopharyngeal and oropharyngeal swallowing pressures in patients treated for oral and oropharyngeal cancer.
    Jun. 2022, Auris, nasus, larynx, 49(3) (3), 477 - 483, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 小山 泰司, 清田 尚臣, 今村 善宣, 土井 久容, 丹田 雅明, 四宮 弘隆, 宮脇 大輔, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2022, 頭頸部癌, 48(2) (2), 182 - 182, Japanese

  • Yu Hashimoto, Shohei Komatsu, Kazuki Terashima, Daisuke Tsugawa, Hiroaki Yanagimoto, Masaki Suga, Yusuke Demizu, Sunao Tokumaru, Tomoaki Okimoto, Ryohei Sasaki, Tetsuo Ajiki, Takumi Fukumoto
    BACKGROUND: Particle therapy (PT) holds a great potential for unresectable hilar cholangiocarcinoma (HC), even though the anatomical proximity to the gastrointestinal tract prevents delivering a radical dose to the tumor. Space-making PT (SMPT), consisting of spacer placement surgery and subsequent PT, has been developed to minimize complications and maximize the therapeutic benefit of dose escalation for HC. This study aimed to examine the effectiveness of SMPT for the treatment of HC. METHODS: Between 2007 and 2018, 12 patients with unresectable HC treated with SMPT were enrolled. The treatment outcomes and effectiveness of spacer placement surgery were evaluated through analyses of pre- and post- surgical parameters of dose volume histograms. RESULTS: The median survival time was 29.6 months, and the 1- and 3-year overall survival rates were 82.5% and 45.8%, respectively. The mean V95% value (volume irradiated with 95% of the planned treatment dose) of the gross tumor volume and clinical target volume after spacer placement surgery improved to 98.5% and 96.6% from preoperative values of 85.6% and 78.1%, respectively (p = 0.0196 and p = 0.0053 respectively). Grade 3 or higher adverse events after SMPT were seen in 6 patients. CONCLUSIONS: SMPT led to improvements in dosimetric parameters and showed good feasibility and excellent outcomes. SMPT can be a promising novel alternative for unresectable HC.
    Apr. 2022, Digestive surgery, 39(2-3) (2-3), 99 - 108, English, International magazine
    Scientific journal

  • 窪田 光, 原 仁美, 江島 泰生, 宮脇 大輔, 角谷 賢一朗, 秋末 敏宏, 酒井 良忠, 岡田 卓也, 今村 善宣, 木澤 義之, 佐々木 良平
    金原出版(株), Apr. 2022, 臨床放射線, 67(4) (4), 365 - 371, Japanese

  • Mohammed Salah, Hiroaki Akasaka, Yasuyuki Shimizu, Kenta Morita, Yuya Nishimura, Hikaru Kubota, Hiroki Kawaguchi, Tomomi Sogawa, Naritoshi Mukumoto, Chiaki Ogino, Ryohei Sasaki
    Apr. 2022, JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 41(1) (1), 146 - 146, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 小児腫瘍に対して空間可変陽子線治療を施行した世界初の症例
    岩田 宏満, 荻野 浩幸, 芝本 雄太, 亀井 美智, 高木 大輔, 近藤 知史, 前田 尚子, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2022, Japanese Journal of Radiology, 40(Suppl.) (Suppl.), 23 - 23, Japanese

  • cT3N0M0声門癌に対する根治的放射線治療の成績
    岩下 和真, 石原 武明, 妹尾 悟史, 窪田 光, 川口 弘毅, 小林 加奈, 宮脇 大輔, 佐々木 良平, 手島 直則, 丹生 健一, 今村 善宣, 清田 尚臣
    (公社)日本医学放射線学会, Feb. 2022, Japanese Journal of Radiology, 40(Suppl.) (Suppl.), 36 - 36, Japanese

  • Yukiya Kitayama, Takuya Yamada, Kentaro Kiguchi, Aoi Yoshida, Shuhei Hayashi, Hiroaki Akasaka, Kazunori Igarashi, Yuya Nishimura, Yu Matsumoto, Ryohei Sasaki, Eri Takano, Hirobumi Sunayama, Toshifumi Takeuchi
    Gold-nanoparticle-incorporated molecularly imprinted nanogels acquire stealth capabilities in vivo through protein corona regulation using intrinsic dysopsonic proteins. The composite can be used in radiation therapy to treat mouse pancreatic cancer.
    Royal Society of Chemistry (RSC), 2022, Journal of Materials Chemistry B, 10(35) (35), 6784 - 6791
    Scientific journal

  • Masanori Teshima, Hirotaka Shinomiya, Hidehito Kimura, Kazunobu Hashikawa, Naomi Kiyota, Daisuke Miyawaki, Ryohei Sasaki, Eiji Kohmura, Ken-Ichi Nibu
    Purpose: To investigate the oncological outcomes of orbital malignant tumors invading the skull base. Methods: A retrospective analysis was conducted on 16 patients with orbital malignant tumors invading the skull base. Eleven patients were treated with skull base surgery, four patients were treated with particle therapies, and one patient was treated with chemoradiotherapy (CRT) as initial treatment. Results: The most frequent histological type was adenoid cystic carcinoma in seven patients, followed by squamous cell carcinoma in two patients. Local recurrence occurred in two of the six surgically treated patients who did not receive postoperative radiotherapy (RT) or CRT. One of them was successfully salvaged by RT, and the other died of disease. With a median follow-up of 24 months, the 2-year overall, local control, and disease-free survival rates of all patients were 82.5%, 87.5%, and 59%, respectively. Conclusions: Patients with positive surgical margins were at risk of local recurrence. Postoperative RT should be considered for all surgically treated patients.Level of Evidence: 4.
    Dec. 2021, Laryngoscope investigative otolaryngology, 6(6) (6), 1347 - 1352, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Maho Azumi, Masuyo Matsumoto, Kaho Suzuki, Ryohei Sasaki, Yoshiko Ueno, Munenobu Nogami, Yoshito Terai
    Radiotherapy (RT) is used to manage cervical cancer, and pelvic insufficiency fracture (PIF) is known as a late complication of RT. The present study identified risk factors for PIF after radiotherapy for cervical cancer, and investigated its incidence rate. It also considered the usefulness of positron emission tomography/magnetic resonance imaging (PET/MRI) in PIF diagnosis. A total of 149 patients with cervical cancer who received definitive or adjuvant RT with/without concurrent chemotherapy between January 2013 and December 2018 were investigated in the present study and followed up for more than one month after RT at Kobe University Hospital. The median follow-up period was 32 months (range, 1-87 months), and the median age of all patients was 66 years (age range, 34-90 years). Computed tomography (CT), MRI, PET/CT or PET/MRI were used for image examination. Among the 149 patients, 31 (20.8%) developed PIF. The median age of these patients was 69 years (age range, 44-87 years). Univariate analysis using the log-rank test demonstrated that age (≥60 years) was significantly associated with PIF. The median maximum standardized uptake value of PIF sites on PET/CT was 4.32 (range, 3.04-4.81), and that on PET/MRI was 3.97 (range, 1.21-5.96) (P=0.162). Notably, the detection time of PIF by PET/MRI was significantly earlier compared with PET/CT (P<0.05). The incidence of PIF after RT for cervical cancer was 20.8%, and age was significantly associated with risk factors for such fractures. Taken together, these results suggest that PET/MRI, which offers the advantage of decreased radiation exposure to the patient, is useful for diagnosing PIF and can detect it earlier than PET/CT imaging.
    Nov. 2021, Oncology letters, 22(5) (5), 776 - 776, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 小児Ewing肉腫症例に対する吸収性スペーサーを用いた体内空間可変陽子線治療 boost照射先行法の試み
    出水 祐介, 美馬 正幸, 福光 延吉, 鈴木 毅, 畠山 理, 小阪 嘉之, 福本 巧, 佐々木 良平, 副島 俊典
    (一社)日本小児血液・がん学会, Oct. 2021, 日本小児血液・がん学会雑誌, 58(4) (4), 306 - 306, Japanese

  • Masao Nakayama, Hiroaki Akasaka, Eiichi Miyazaki, Yoshihiro Goto, Yuya Oki, Yosuke Kawate, Kenta Morita, Ryohei Sasaki
    Oct. 2021, PHYSICS & IMAGING IN RADIATION ONCOLOGY, 20, 94 - 97, English
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiroaki Akasaka, Yuya Oki, Kazufusa Mizonobe, Kazuyuki Uehara, Hiroshi Mayahara, Aya Harada, Naoki Hashimoto, Keiji Kitatani, Tomonori Yabuuchi, Takeaki Ishihara, Kazuma Iwashita, Daisuke Miyawaki, Naritoshi Mukumoto, Ai Nakaoka, Ryohei Sasaki
    Cambridge University Press, Sep. 2021, Journal of Radiotherapy in Practice, 20(3) (3), 294 - 299, English
    Scientific journal

  • Hirotaka Shinomiya, Natsumi Uehara, Takeshi Fujita, Daisuke Miyawaki, Yoshinori Imamura, Masanori Teshima, Akinobu Kakigi, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu
    PURPOSE: Chemoradiotherapy with docetaxel (DOC), cisplatin (CDDP), and 5-FU (TPF-CRT) for locally advanced external auditory canal cancer (EACC) has favorable oncological and functional outcomes. To establish TPF-CRT as a standard of care for advanced EACC, we conducted this study to determine the maximum tolerated (MTD) and recommended dose (RD) of DOC in TPF-CRT for locally advanced EACC. METHODS: To determine the recommended (RD) and maximum tolerated dose (MTD) of DOC in TPF-CRT for EACC, a phase I trial was conducted using the standard "3 + 3" design for maximum dose finding. DOC was administered twice every 4 weeks, CDDP at 70 mg/m2 and 5-FU at 700 mg/m2; patients were also receiving radiotherapy (66 Gy). Eight patients with T3 or T4 EACC were prospectively enrolled. RESULTS: Two patients treated with DOC, 50 mg/m2, and one out of six patients treated with DOC, 40 mg/m2, had dose-limiting toxicities. Prolonged febrile neutropenia was observed in three patients. Grade 3 non-hematological toxicities were observed in only three patients. At study completion, six patients survived, five of whom were disease free. CONCLUSION: The RD and MTD of DOC in TPF-CRT for locally advanced EACC are 40 mg/m2 when doses of CDDP and 5-FU are 70 mg/m2 and 700 mg/m2, respectively.
    Jul. 2021, European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 279(6) (6), 2805 - 2810, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Mostafa Hamada, Eisuke Ueshima, Takeaki Ishihara, Yutaka Koide, Takuya Okada, Hiroki Horinouchi, Jun Ishida, Hiroshi Mayahara, Koji Sasaki, Tomoyuki Gentsu, Keitaro Sofue, Masato Yamaguchi, Ryohei Sasaki, Koji Sugimoto, Takamichi Murakami
    Background Technological developments have led to an increased usage of external-body radiotherapy (RT) for the treatment of hepatocellular carcinoma (HCC). Transcatheter arterial chemoembolization (TACE) may be required later in patients treated with RT because of the high recurrence rate and multinodular presentation of HCC. However, despite the risk of liver function impairment, the cumulative liver damage correlated with TACE following a hepatic RT has not been adequately assessed. Purpose To evaluate the feasibility of TACE following RT for HCC. Materials and methods Sixty-seven patients with HCC who underwent TACE after RT were retrospectively evaluated between 2012 and 2018. We assessed increases in Child–Turcotte–Pugh (CTP) by ≥2 points at 1 month, the incidence of major complications, survival duration, and short-term mortality within 6 months after TACE. Furthermore, we evaluated the predictive factors for liver function impairment and short-term mortality. Results Eight patients experienced a CTP increase ≥2 points at 1 month. There were no cases of liver abscesses or bilomas. Nine patients died within 6 months following TACE. The mean liver dose (MLD) was a significant predictor of liver function impairment at 1 month ( p = 0.042). Low liver functional reserve, distant metastasis ( p = 0.037), MLD ( p = 0.046), TACE type ( p = 0.025), and TACE within 3 months following RT ( p = 0.007) were significant predictors of short-term mortality. Conclusions Despite the feasibility of TACE following RT, clinicians should pay attention to impaired pretreatment liver function, following high dose RT, and the short duration between RT and TACE.
    SAGE Publications, Jul. 2021, Acta Radiologica Open, 10(7) (7), 205846012110349 - 205846012110349, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Daisuke Takagi, Yuri Morikawa, Michi Kamei, Hiroyuki Ogino, Hiromitsu Iwata, Naoko Maeda, Nobuhiro Akita, Takumi Fukumoto, Ryohei Sasaki, Satoshi Kondo
    May 2021, Pediatric blood & cancer, 68(5) (5), e28842, English, International magazine

  • ウサギVX2腫瘍モデルを用いた過酸化チタンナノ粒子動注の基礎的研究
    岡田 卓也, 元津 倫幸, 西村 勇哉, 森田 健太, 上嶋 英介, 山口 雅人, 杉本 幸司, 佐々木 良平, 荻野 千秋, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, Apr. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 191 - 191, Japanese

  • 切除不能肝門部領域胆管癌に対するスペーサ手術および粒子線治療
    橋本 悠, 小松 昇平, 寺嶋 千貴, 柳本 泰明, 津川 大介, 出水 祐介, 徳丸 直郎, 権 英寿, 白川 幸代, 山下 博成, 蔵満 薫, 寺井 祥雄, 田中 基文, 浅利 貞毅, 木戸 正浩, 外山 博近, 味木 徹夫, 沖本 智昭, 佐々木 良平, 福本 巧
    (一社)日本外科学会, Apr. 2021, 日本外科学会定期学術集会抄録集, 121回, SF - 1, Japanese

  • Ai Nakaoka, Makiko Nakahana, Sachiko Inubushi, Hiroaki Akasaka, Mohammed Salah, Yoshiko Fujita, Hikaru Kubota, Mennaallah Hassan, Ryo Nishikawa, Naritoshi Mukumoto, Takeaki Ishihara, Daisuke Miyawaki, Takashi Sasayama, Ryohei Sasaki
    Apr. 2021, ONCOLOGY REPORTS, 45(4) (4), English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • H Shinomiya, N Uehara, T Fujita, K Yoshida, Y Imamura, M Teshima, H Kimura, D Miyawaki, A Kakigi, N Kiyota, N Otsuki, R Sasaki, E Kohmura, K Nibu
    AbstractBackgroundThe prognosis of patients with advanced squamous cell carcinoma of the external auditory canal and middle ear has been improved by advances in skull base surgery and multidrug chemoradiotherapy during the last two decades. MethodsNinety-five patients with squamous cell carcinoma of the external auditory canal and middle ear who were treated between 1998 and 2017 were enrolled. The number of patients with tumour stages T1, T2, T3 and T4 was 15, 22, 24 and 34, respectively. Oncological outcomes and prognostic factors were retrospectively investigated. ResultsAmong patients with T4 disease, invasion of the brain (p = 0.024), carotid artery (p = 0.049) and/or jugular vein (p = 0.040) were significant predictors of poor prognosis. The five-year overall survival rate of patients with at least one of these factors (T4b) was significantly lower than that of patients without these factors (T4a) (25.5 vs 65.5 per cent, p = 0.049). ConclusionIt is proposed that stage T4 be subclassified into T4a and T4b according to the prognostic factors.
    Cambridge University Press (CUP), Apr. 2021, The Journal of Laryngology & Otology, 135(4) (4), 297 - 303
    Scientific journal
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  • Hitomi Hara, Yoshitada Sakai, Teruya Kawamoto, Naomasa Fukase, Yohei Kawakami, Toshiyuki Takemori, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Kenichiro Kakutani, Takahiro Niikura, Daisuke Miyawaki, Takuya Okada, Akihiro Sakashita, Yoshinori Imamura, Ryohei Sasaki, Yoshiyuki Kizawa, Hironobu Minami, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Toshihiro Akisue
    Background: Skeletal related events due to metastatic bone tumors markedly affect the activities of daily living (ADL) and quality of life (QOL) in cancer patients. We focused on multidisciplinary therapy for metastatic bone tumors. This study aimed to evaluate the outcomes of surgical treatment for metastatic bone tumors in the extremities. Methods: We retrospectively reviewed 114 patients who underwent surgical treatment for metastatic bone tumors of the extremities between 2008 and 2019 and 69 patients were reassessed for more than 6 months after surgery. The most common primary tumor was renal, followed by lung, thyroid, and breast cancers. We assessed 69 patients' performance status (PS), Barthel Index (BI) for ADL, EuroQol 5 Dimensions (EQ-5D) for QOL, and numerical rating scale (NRS) for pain and analyzed these postoperative values relative to preoperative values using Friedman's test. The postoperative overall survival and the prognostic factors were evaluated using the Kaplan-Meier method, the log-rank test and Cox proportional hazards analysis. Results: The 1-year overall survival rate was 59%, and the median survival time after surgery was 20 months. Primary tumor, visceral metastasis, and surgical procedure were risk factors correlated with overall survival. PS, BI, EQ-5D, and NRS improved at 3 months after surgery and these improvements were maintained for 6 months after surgery regardless of the surgical procedure. Conclusions: The significant factors affecting survival after surgical treatment for bone metastases included the primary tumor, presence of visceral metastases, and internal fixation without tumor resection or curettage. Surgical treatment for metastatic bone tumors effectively reduced pain and improved PS, ADL, and QOL postoperatively after 3 months.
    Apr. 2021, Journal of bone oncology, 27, 100352 - 100352, English, International magazine
    Scientific journal
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  • Katsuki Tsutsumi, Hirobumi Sunayama, Yukiya Kitayama, Eri Takano, Yuji Nakamachi, Ryohei Sasaki, Toshifumi Takeuchi
    Wiley, Apr. 2021, Advanced NanoBiomed Research, 1(4) (4), 2000079 - 2000079
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Kenta Morita, Yuya Nishimura, Satoko Nakamura, Yuki Arai, Chiya Numako, Kazuyoshi Sato, Masao Nakayama, Hiroaki Akasaka, Ryohei Sasaki, Chiaki Ogino, Akihiko Kondo
    Polyacrylic acid-modified titanium peroxide nanoparticles (PAA-TiOx NPs) are promising radiosensitizers that enhance the therapeutic effect of X-ray irradiation after local injection into tumors. However, the mechanism for this reaction has remained unclear with the exception of the involvement of hydrogen peroxide (H2O2), which is released by PAA-TiOx NPs to a liquid phase during dispersion. In the present study, a clonogenic assay was used to compare PAA-TiOx NPs with free H2O2 molecules to investigate the effect exerted on the radiosensitivity of cancer cells in vitro. A cell-free dialysis method revealed that a portion of the H2O2 adsorbed onto the PAA-TiOx NPs during synthesis could be released during a treatment regimen. The H2O2 release lasted for 7 h, which was sufficient for one radiation treatment procedure. For in vitro experiments, cultured human pancreatic cancer cells took up PAA-TiOx NPs in 10 min after administration. Interestingly, when the cells were washed with a buffer after treatment with either a PAA-TiOx NP or H2O2 solution, the intracellular H2O2 levels remained higher with PAA-TiOx NP treatment compared with the H2O2 solution treatment. Furthermore, the effects of subsequent X-ray irradiation corresponded to the intracellular H2O2 levels. These results indicate that PAA-TiOx NPs are efficient carriers of H2O2 into cancer cells and thus enhance the radiosensitivity.
    Elsevier BV, Feb. 2021, Colloids and Surfaces B: Biointerfaces, 198, 111451 - 111451, English, International magazine
    Scientific journal

  • Dongha Lee, Shohei Komatsu, Kazuki Terashima, Hirochika Toyama, Yoshiro Matsuo, Daiki Takahashi, Masaki Suga, Naoko Nishimura, Kentaro Tai, Masahiro Kido, Yusuke Demizu, Sunao Tokumaru, Tomoaki Okimoto, Ryohei Sasaki, Takumi Fukumoto
    BACKGROUND: Particle radiotherapy has increasingly gained acceptance for locally advanced pancreatic cancers owing to superior tumor conformity and dosimetry compared to conventional photon radiotherapy. However, the close proximity of the pancreas to the stomach and duodenum leads to radiation-induced gastrointestinal toxicities, which hinder the delivery of curative doses to the tumor. To overcome this problem, a surgical spacer was placed between the tumor and gastrointestinal tract, and subsequent proton radiotherapy was performed in this study. METHODS: Data from 9 patients who underwent surgical spacer placement and subsequent proton radiotherapy were analyzed. The safety and feasibility of the spacer placement surgery were evaluated; the impact of the spacer on dosimetry was also assessed using dose volume histogram (DVH) analyses, before and after surgical spacer placement. RESULTS: Surgical spacer placement and subsequent proton radiotherapy were successfully completed in all cases. Surgical spacer placement significantly improved the dose intensity covering 95%, mean, and minimum doses for the gross tumor volume, and the clinical and planning target volume based on the DVH, while respecting the dose constraints of the gastrointestinal tract. Based on the Common Terminology Criteria for Adverse Events, two patients (22.2%) developed gastrointestinal ulcer (Grade 2) at 1 and 35 months, and one patient (11.1%) developed gastric perforation (Grade 4) at 4 months after proton radiotherapy. CONCLUSIONS: Surgical spacer placement in the locally advanced pancreatic body and tail cancers is relatively safe and technically feasible. Comparing radiation plans, surgical spacer placement seems to improve the dose distribution in the locally advanced pancreatic body and tail cancers, which are close to the gastrointestinal tract.
    Jan. 2021, Radiation oncology (London, England), 16(1) (1), 3 - 3, English, International magazine
    Scientific journal
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  • Hikaru Kubota, Daisuke Miyawaki, Naritoshi Mukumoto, Takeaki Ishihara, Megumi Matsumura, Takumi Hasegawa, Masaya Akashi, Naomi Kiyota, Hirotaka Shinomiya, Masanori Teshima, Ken-Ichi Nibu, Ryohei Sasaki
    BACKGROUND: To evaluate factors associated with osteoradionecrosis of the jaw (ORNJ) in patients with head and neck squamous cell carcinoma (HNSCC), focusing on jaw-related dose-volume histogram (DVH) parameters. METHODS: We retrospectively reviewed the medical records of 616 patients with HNSCC treated with curative-intent or postoperative radiation therapy (RT) during 2008-2018. Patient-related (age, sex, history of smoking or alcohol use, diabetes mellitus, performance status, pre-RT dental evaluation, pre- or post-RT tooth extraction), tumor-related (primary tumor site, T-stage, nodal status), and treatment-related (pre-RT surgery, pre-RT mandible surgery, induction or concurrent chemotherapy, RT technique) variables and DVH parameters (relative volumes of the jaw exposed to doses of 10 Gy-70 Gy [V10-70]) were investigated and compared between patients with and without ORNJ. The Mann-Whitney U test was used to compare RT dose parameters. Univariate and multivariate Cox regression analyses were used to assess factors associated with ORNJ development. Kaplan-Meier analyses were performed for cumulative ORNJ incidence estimation. RESULTS: Forty-six patients (7.5%) developed ORNJ. The median follow-up duration was 40 (range 3-145) months. The median time to ORNJ development was 27 (range 2-127) months. DVH analysis revealed that V30-V70 values were significantly higher in patients with than in those without ORNJ. In univariate analyses, primary tumor site, pre-RT mandible surgery, post-RT tooth extraction, and V60 > 14% were identified as important factors. In multivariate analyses, V60 > 14% (p = 0.0065) and primary tumor site (p = 0.0059) remained significant. The 3-year cumulative ORNJ incidence rates were 2.5% and 8.6% in patients with V60 ≤ 14% and > 14%, respectively (p < 0.0001), and 9.3% and 1.4% in patients with oropharyngeal or oral cancer and other cancers, respectively (p < 0.0001). CONCLUSIONS: V60 > 14% and oropharyngeal or oral cancer were found to be independent risk factors for ORNJ. These findings might be useful to minimize ORNJ incidence in HNSCC treated with curative RT.
    Jan. 2021, Radiation oncology (London, England), 16(1) (1), 1 - 1, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiroaki Akasaka, Kazufusa Mizonobe, Yuya Oki, Kazuyuki Uehara, Aya Harada, Shuichiro Miyazaki, Keiji Kitatani, Tomonori Yabuuchi, Takeaki Ishihara, Daisuke Miyawaki, Masao Nakayama, Naritoshi Mukumoto, Ryuichi Yada, Ai Nakaoka, Hikaru Kubota, Hiroki Kawaguchi, Satoshi Seno, Ryohei Sasaki, Hiroshi Mayahara
    Cambridge University Press, 2021, Journal of Radiotherapy in Practice, English
    Scientific journal

  • Hiroki Kawaguchi, Yusuke Demizu, Naritoshi Mukumoto, Takeaki Ishihara, Daisuke Miyawaki, Shohei Komatsu, Hiroaki Akasaka, Makoto Shinoto, Yoshiyuki Shioyama, Katsumasa Nakamura, Takumi Fukumoto, Ryohei Sasaki
    BACKGROUND/AIM: We aimed to investigate the dosimetric effects of a spacer placed between the pancreas and surrounding gastrointestinal structures in intensity-modulated radiation therapy (IMRT) planning to provide more effective radiation therapy for locally advanced pancreatic cancer (LAPC). PATIENTS AND METHODS: Treatment planning was performed for six patients with LAPC based on computed tomography images without spacers and with 5-mm or 10-mm spacers virtually inserted under the supervision of a hepatobiliary pancreatic surgeon. The prescription dose was 63 Gy in 28 fractions. RESULTS: With the exception of one case of pancreatic head cancer, planning target volume receiving ≥95% of the prescribed dose (PTV V95) was achieved by 90% or more by inserting a spacer, and by 95% or more in all 3 cases of pancreatic body and tail cancer by inserting a 10-mm spacer. CONCLUSION: IMRT with appropriate spacer placement may help provide high-dose treatment for LAPC and improve associated patient outcomes.
    Jan. 2021, Anticancer research, 41(1) (1), 503 - 508, English, International magazine
    Scientific journal

  • Yuya Nishimura, Ryosuke Ezawa, Kenta Morita, Masao Nakayama, Jun Ishii, Ryohei Sasaki, Chiaki Ogino, Akihiko Kondo
    American Chemical Society (ACS), Nov. 2020, ACS Applied Bio Materials, 3(11) (11), 7743 - 7751
    Scientific journal

  • Masahiko Kashin, Yasumasa Kakei, Shun Teraoka, Takumi Hasegawa, Akinobu Yamaguchi, Takao Fukuoka, Ryohei Sasaki, Masaya Akashi
    Cetuximab, an epidermal growth factor receptor inhibitor (EI), is currently the only targeted molecular therapy used in combination with radiotherapy for head and neck squamous cell carcinoma (HNSCC). Gold nanoparticles (AuNPs) are expected to enhance radiotherapy effects in cancers. To investigate whether AuNPs combined with AG1478, an EI, enhanced irradiation effects on HNSCC cells, we first examined AG1478 adsorption on AuNP surfaces, using surface-enhanced Raman scattering, which indicated an adsorption equilibrium of AG1478 to AuNPs. We then used transmission electron microscopy to find internalization rates of AuNP alone and AuNP+AG1478; we found that intracellular uptake of AuNP alone and AuNP+AG1478 did not significantly differ. We compared cell numbers, proliferation, apoptosis, and migration between control cells and those treated with or without 60 nm AuNP (1.0 nM), AG1478 (0.5 μM), and irradiation (4 Gy). We found that AuNP+AG1478 inhibited proliferation more than AG1478 alone; the combination of irradiation+AuNP+AG1478 significantly reduced total cell numbers compared with the combination of irradiation+AuNP; AuNP+AG1478 increased apoptotic reaction to irradiation; the combinations of AuNP+AG1478 and irradiation+AuNP induced more apoptosis than AG1478+irradiation. Whereas AuNP+AG1478 enhanced cytotoxicity in human HNSCC cells by inhibiting proliferation, irradiation+AuNP enhanced cytotoxicity by inducing apoptosis.
    Hindawi Limited, Nov. 2020, BioMed Research International, 2020, 1 - 10, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 古川 皓一, 立原 素子, 佐藤 宏紀, 高田 尚哉, 三村 千尋, 梅澤 佳乃子, 桂田 直子, 山本 正嗣, 永野 達也, 小林 和幸, 西村 善博, 石原 武明, 佐々木 良平
    (NPO)日本肺癌学会, Oct. 2020, 肺癌, 60(6) (6), 700 - 700, Japanese

  • Tianyuan Wang, Sachiko Inubushi, Naoko Ikeo, Toshiji Mukai, Keisuke Okumura, Hiroaki Akasaka, Ryuichi Yada, Kenji Yoshida, Daisuke Miyawaki, Takeaki Ishihara, Ai Nakaoka, Ryohei Sasaki
    Oct. 2020, Medical Physics, 47(10) (10), 4703 - 4710, English, International magazine
    [Refereed]
    Scientific journal

  • 放射線治療の照射領域とその周辺領域に複数の基底細胞癌を発症した1例
    大塚 晴彦, 福本 毅, 藤原 進, 坂口 正展, 岡 昌宏, 錦織 千佳子, 矢田 隆一, 佐々木 良平
    日本皮膚科学会-大阪地方会・京滋地方会, Sep. 2020, 皮膚の科学, 19(3) (3), 212 - 212, Japanese

  • 高木 大輔, 近藤 知史, 亀井 美智, 荻野 浩幸, 岩田 宏満, 前田 尚子, 秋田 直洋, 増本 幸二, 福島 紘子, 文野 誠久, 石田 裕二, 淡河 恵津世, 出水 祐介, 福本 巧, 佐々木 良平
    (一社)日本小児外科学会, Sep. 2020, 日本小児外科学会雑誌, 56(5) (5), 630 - 630, Japanese

  • Mohammed Salah, Saki Osuga, Makiko Nakahana, Yasuhiro Irino, Masakazu Shinohara, Yasuyuki Shimizu, Naritoshi Mukumoto, Hiroaki Akasaka, Ai Nakaoka, Daisuke Miyawaki, Takeaki Ishihara, Kenji Yoshida, Yoshiaki Okamoto, Ryohei Sasaki
    Gastrointestinal toxicity is frequently observed secondary to accidental or therapeutic radiation exposure. However, the variation in the intestinal metabolites after abdominal radiation exposure remains ambiguous. In the present study, C57BL/6 mice were exposed to 0, 2, and 20 Gy irradiation dose. The Head and chest of each mouse were covered with a lead shield before x-ray irradiation. 24 h post-irradiation treatment, intestinal tissue of each mouse was excised and prepared for metabolites measurement using gas chromatography-mass spectrometry (GC-MS). Our comprehensive analysis of metabolites in the intestinal tissues detected 44 metabolites after irradiation, including amino acids, carbohydrates, organic acids, and sugars. Amino acid levels in the intestinal tissue gradually rose, dependent on the radiation dose, perhaps as an indication of oxidative stress. Our findings raise the possibility that amino acid metabolism may be a potential target for the development of treatments to alleviate or mitigate the harmful effects of oxidative stress-related gastrointestinal toxicity due to radiation exposure.
    Sep. 2020, Biochemistry and biophysics reports, 23, 100789 - 100789, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 腹部悪性腫瘍に対する粒子線治療適応拡大を目指した新規素材吸収性スペーサーの開発
    小松 昇平, 木戸 正浩, 寺嶋 千貴, 出水 祐介, 粟津 正英, 津川 大介, 椋棒 英世, 蔵満 薫, 寺井 祥雄, 田中 基文, 柳本 泰明, 外山 博近, 味木 徹夫, 沖本 智昭, 佐々木 良平, 福本 巧
    (一社)日本外科学会, Aug. 2020, 日本外科学会定期学術集会抄録集, 120回, SF - 4, Japanese

  • Ryuichi Yada, Kazusuke Maenaka, Shuji Miyamoto, Go Okada, Aki Sasakura, Motoi Ashida, Masashi Adachi, Tatsuhiko Sato, Tianyuan Wang, Hiroaki Akasaka, Naritoshi Mukumoto, Yasuyuki Shimizu, Ryohei Sasaki
    Aug. 2020, MEDICAL PHYSICS, 47(10) (10), 5235 - 5249, English, International magazine
    [Refereed]
    Scientific journal

  • 頭頸部癌における臓器温存療法は本当に機能温存につながっているのか 3D-CRTからIMRTへと変遷する中での放射線療法の課題
    佐々木 良平, 窪田 光, 川口 弘毅, 宮脇 大輔
    (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 114 - 114, Japanese

  • 小児・若年の上咽頭癌3例の治療経験
    宮脇 大輔, 妹尾 悟史, 窪田 光, 川口 弘毅, 石原 武明, 植村 優, 山本 暢之, 今村 善宣, 清田 尚臣, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 168 - 168, Japanese

  • 頭頸部癌における免疫チェックポイント阻害薬後の救済化学療法についての後方視的検討
    小山 泰司, 清田 尚臣, 今村 善宣, 長谷 善明, 高倉 嗣丈, 蓼原 瞬, 入谷 啓介, 古川 竜也, 手島 直則, 四宮 弘隆, 宮脇 大輔, 明石 昌也, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 174 - 174, Japanese

  • 当院における頭頸部がんに対する高用量シスプラチン併用化学放射線療法による急性腎障害の後方視的検討
    高倉 嗣丈, 今村 善宣, 小山 泰司, 長谷 善明, 四宮 弘隆, 手島 直則, 古川 竜也, 入谷 啓介, 蓼原 瞬, 宮脇 大輔, 明石 昌也, 佐々木 良平, 丹生 健一, 清田 尚臣
    (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 185 - 185, Japanese

  • Mennaallah Hassan, Masao Nakayama, Mohammed Salah, Hiroaki Akasaka, Hikaru Kubota, Makiko Nakahana, Tatsuichiro Tagawa, Kenta Morita, Ai Nakaoka, Takeaki Ishihara, Daisuke Miyawaki, Kenji Yoshida, Yuya Nishimura, Chiaki Ogino, Ryohei Sasaki
    The development of potentially safe radiosensitizing agents is essential to enhance the treatment outcomes of radioresistant cancers. The titanium peroxide nanoparticle (TiOxNP) was originally produced using the titanium dioxide nanoparticle, and it showed excellent reactive oxygen species (ROS) generation in response to ionizing radiation. Surface coating the TiOxNPs with polyacrylic acid (PAA) showed low toxicity to the living body and excellent radiosensitizing effect on cancer cells. Herein, we evaluated the mechanism of radiosensitization by PAA-TiOxNPs in comparison with gold nanoparticles (AuNPs) which represent high-atomic-number nanoparticles that show a radiosensitizing effect through the emission of secondary electrons. The anticancer effects of both nanoparticles were compared by induction of apoptosis, colony-forming assay, and the inhibition of tumor growth. PAA-TiOxNPs showed a significantly more radiosensitizing effect than that of AuNPs. A comparison of the types and amounts of ROS generated showed that hydrogen peroxide generation by PAA-TiOxNPs was the major factor that contributed to the nanoparticle radiosensitization. Importantly, PAA-TiOxNPs were generally nontoxic to healthy mice and caused no histological abnormalities in the liver, kidney, lung, and heart tissues.
    Jun. 2020, Nanomaterials (Basel, Switzerland), 10(6) (6), English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Masao Nakayama, Hiroaki Akasaka, Moshi Geso, Kenta Morita, Ryuichi Yada, Kazuyuki Uehara, Ryohei Sasaki
    Jun. 2020, RADIATION MEASUREMENTS, 134, English
    Scientific journal

  • SACHIKO INUBUSHI, HIROKI KAWAGUCHI, SACHIKO MIZUMOTO, TOMONARI KUNIHISA, MOTOI BABA, YUKIYA KITAYAMA, TOSHIFUMI TAKEUCHI, ROBERT M. HOFFMAN, RYOHEI SASAKI
    BACKGROUND/AIM: Exosomes are produced by normal and cancer cells. Exosomes are found in the serum of cancer patients and have been used for diagnosis and prognosis. Recently tears from non-cancer patients have been found to contain exosomes. In the present report we describe tears from advanced breast-cancer patients. MATERIALS AND METHODS: We found oncogenic miRNAs in the exosomes isolated from tear fluids obtained from five patients with metastatic breast cancer and compared them with tear exosomes form eight healthy volunteers. RESULTS: Tear exosomes had a significantly higher quantity of exosome markers than serum exosomes (CD9, CD63). Tear exosomes were subjected to quantitative reverse-transcription polymerase reaction (qRT-PCR), and western blot analysis to elucidate the status of miRNAs, previously reported in serum from patients with metastatic breast cancer. qRT-PCR and western-blot analysis revealed that breast-cancer-specific miR-21 and miR-200c were highly expressed in tear exosomes from metastatic breast cancer patients in contrast to tear exosomes from healthy volunteers. CONCLUSION: Tear exosomes can be a potential source of diagnostic and prognostic biomarkers for metastatic breast cancer, and possibly other cancers or diseases.
    Anticancer Research USA Inc., Jun. 2020, Anticancer Research, 40(6) (6), 3091 - 3096, English, International magazine
    [Refereed]
    Scientific journal

  • Hiroshi Onishi, Yoshiyuki Shioyama, Yasuo Matsumoto, Yuta Shibamoto, Akifumi Miyakawa, Gen Suzuki, Yasumasa Nishimura, Ryohei Sasaki, Daisuke Miyawaki, Kengo Kuriyama, Takafumi Komiyama, Kan Marino, Shinichi Aoki, Ryo Saito, Masayuki Araya, Yoshiyasu Maehata, Hotaka Nonaka, Licht Tominaga, Masahide Saito, Naoki Sano, Shogo Yamada
    Abstract We retrospectively reviewed the effect of stereotactic body radiation therapy (SBRT) in patients with stage I lung cancer whose lung tumor showed a nodular appearance of ground glass opacity, so-called ground glass nodule (GGN). A total of 84 patients (42 men, 42 women; mean age, 75 years) with stage I lung cancer with GGN accompanying a solid component &lt;50% in diameter of the tumor and no metastases were studied. Concerning histology, 32 tumors were adenocarcinoma, 1 was squamous cell carcinoma, 2 were unclassified carcinoma and 49 cases were histology-unproven but increased in size or had a positive finding in 18F-FDG positron emission tomography (PET) examination. The median tumor size was 20 mm (range, 10–41 mm). All of the patients were treated with SBRT, and the total prescribed dose at the isocenter ranged between 48 Gy in four fractions and 84 Gy in ten fractions. Median follow-up duration was 33 months. No patient had local failure nor regional lymph node failure. The 3-year rate of distant failure was 2.6%. Two patients who experienced distant metastases had a past surgical history of initial lung cancer before SBRT. The rates of cause-specific and overall survival at 3 years were 98.2 and 94.6%, respectively. Treatment-related adverse events of ≥grade 4 were not reported. Although more cases and longer follow-ups are mandatory, SBRT may be one of the radical treatment options for patients with GGN.
    Oxford University Press (OUP), May 2020, Journal of Radiation Research, 61(3) (3), 426 - 430, English, International magazine
    [Refereed]
    Scientific journal

  • Toshifumi Takeuchi, Kisho Mori, Hirobumi Sunayama, Eri Takano, Yukiya Kitayama, Taku Shimizu, Yuzuki Hirose, Sachiko Inubushi, Ryohei Sasaki, Hirokazu Tanino
    Small extracellular vesicles (sEVs) are reliable biomarkers for early cancer detection; however, conventional detection methods such as immune-based assays and microRNA analyses are not very sensitive and require sample pretreatments and long analysis time. Here, we developed a molecular imprinting-based dynamic molding approach to fabricate antibody-conjugated signaling nanocavities capable of size recognition. This enabled the establishment of an easy-to-use, rapid, sensitive, pretreatment-free, and noninvasive sEV detection platform for efficient sEV detection-based cancer diagnosis. An apparent dissociation constant was estimated to be 2.4 × 10-16 M, which was ∼1000 times higher than that of commercial immunoassays (analysis time, 5 min/sample). We successfully used tears for the first time to detect cancer-related intact sEVs, clearly differentiating between healthy donors and breast cancer patients, as well as between samples collected before and after total mastectomy. Our nanoprocessing strategy can be easily repurposed for the specific detection of other types of cancer by changing the conjugated antibodies, thereby facilitating the establishment of liquid biopsy for early cancer diagnosis.
    Apr. 2020, Journal of the American Chemical Society, 142(14) (14), 6617 - 6624, English, International magazine
    [Refereed]
    Scientific journal

  • Daryl Anne A. del Mundo, Koichi Morimoto, Kuriko Masuda, Shinobu Iwaki, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Daisuke Miyawaki, Naoki Otsuki, Ryohei Sasaki, Ken-ichi Nibu
    OBJECTIVE: To investigate the oncological and functional outcomes of the patients treated with transoral CO2 laser cordectomy for early glottic cancer. PATIENTS AND METHODS: Fifty-five consecutive patients who underwent CO2 laser cordectomy for early glottic cancer were retrospectively reviewed. RESULTS: Overall survival, larynx preservation, and relapse free local control rates were 96%, 100%, and 91%, respectively. Five patients with local recurrences were salvaged with re-cordectomy and/or radiotherapy. In type I cordectomy, VHI-10 consistently improved during postoperative course and VHI-10 at postoperative 12months was significantly better than preoperative value (2.3 vs. 9.4, p=0.02). Perceptual grading, MPT, MFR and AC/DC also improved and were better than preoperative values. In type III cordectomy, shimmer at 12months after cordectomy was significantly better than preoperative value (14.7 vs. 9.3, p=0.007). CONCLUSIONS: These results further support the rationale of CO2 cordectomy as initial and salvage surgery for early glottic cancer.
    Elsevier BV, Apr. 2020, Auris Nasus Larynx, 47(2) (2), 276 - 281, English, International magazine
    Scientific journal

  • Satoshi Takeuchi, Haruo Kuroboshi, Taisuke Mori, Kimihiko Ito, Eiji Kondo, Tsutomu Tabata, Yoshio Itani, Ryuji Kawaguchi, Kyosuke Takeuchi, Toshinori Soejima, Ryohei Sasaki
    Objective: Concurrent chemoradiotherapy using cisplatin was thought to be standard treatment for squamous cell carcinoma of cervix, but it had not been effective for adenocarcinoma. Concurrent chemoradiotherapy using irinotecan hydrochloride (CPT-11) had been effective for colorectal cancer, thus, we chose CPT-11 as a candidate for gynecologic adenocarcinoma. To evaluate the maximum tolerated dose (MTD) of weekly CPT-11 with external pelvic radiotherapy, a phase 1/2 study was conducted according to modified Fibonacci method. Methods: Eligible patients were advanced uterine cancer with measurable diseases [performance score (PS): 0-2]. Study period was from August 1st, 2002 to December 31st, 2008. The starting dose level (DL) of CPT-11 was 30 mg/m2 (DL1) given weekly for 4 weeks. Subsequently, dose escalation was scheduled in 10 mg/m2 increments to 60 mg/m2 (DL4). The fixed radiotherapy consisted of whole pelvic 1.8 Gy/d, once a day in weekday for five weeks and it amounted to 45 Gy (25 fractions) in total. Results: Seventeen patients were enrolled. As for toxicities, one (1/17: 5.9%) grade (G) 4 neutropenia lasting 7 days had been seen in DL4. G2 diarrhea was identified in 35.3% (6/17) of the patients, and 11.8% (2/17) G3 diarrhea was observed in DL3 and DL4. Thus, the MTD of CPT-11 was defined as dose of 60 mg/m2. The recommended dose was decided as 50 mg/m2. The response rate was 88.2% [9 complete response (CR), 3 partial response (PR), 3 stable disease (SD), 2 not evaluable (NE)]. Disease control rate at 1 month after treatment completion was 100% but distant metastases were found in 24% (4/17) in longer outcome. Conclusions: MTD was 60 mg/m2 and recommended dose was set as 50 mg/m2. This concurrent chemoradiation using weekly CPT-11 was feasible at 50 mg/m2, and it might be effective even in adenocarcinoma of the uterus.
    Apr. 2020, Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 32(2) (2), 218 - 227, English, International magazine
    Scientific journal

  • 木村氏病3例に対する放射線治療の経験
    妹尾 悟史, 宮脇 大輔, 吉田 賢史, 石原 武明, 西川 遼, 井上 由子, 窪田 光, 佐々木 香織, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2020, Japanese Journal of Radiology, 38(Suppl.) (Suppl.), 40 - 40, Japanese

  • Takeshi Ioroi, Naomi Kiyota, Yoshinori Imamura, Masaaki Tanda, Shiori Aoki, Mamoru Okuno, Kazuhiro Yamamoto, Ryohei Sasaki, Ken-Ichi Nibu, Hironobu Minami, Midori Hirai, Ikuko Yano
    Background: Oral mucositis frequently occurs in cancer patients treated with chemotherapy and chemoradiotherapy (CRT). This study examined the safety and efficacy of ibuprofen gargle in healthy volunteers and patients with chemotherapy- and concomitant CRT-induced oral mucositis. Methods: We enrolled healthy volunteers and patients with chemotherapy- and CRT-induced oral mucositis. In cohort I, single and multiple doses of ibuprofen gargle (0.6% or 1.0%) were administered to healthy volunteers on day 1 and days 4-10. In cohort II, multiple doses of ibuprofen gargle (0.6%) were administered to patients with complicated grade 2-3 oral mucositis based on the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. The primary endpoint of cohort I was the treatment-related adverse events (TRAEs) as defined by CTCAE version 4.0. The primary endpoint of cohort II was the change in the visual analogue scale (VAS) pain score from before to 15 min after gargle use on day 3. The incidence and severity of TRAEs were assessed based on the CTCAE version 4.0 and a subjective rating scale completed by healthy volunteers and patients. Results: In cohort I, 9 of 10 healthy volunteers were evaluable for safety. All 9 healthy volunteers reported the TRAE of oral irritation with single or multiple use of the gargle. In cohort II, 10 patients were enrolled and evaluable for safety and 7 of 10 patients were evaluable for efficacy. The mean change in the VAS pain score from before to 15 min after using the gargle on day 3 was - 1.28 (95% confidence interval: - 2.06, - 0.51), and all patients experienced some degree of pain relief (range: - 0.2 to - 2.5). All 10 patients reported the TRAE of oral irritation. No other TRAEs of ibuprofen gargle were observed in the healthy volunteers and patients. Conclusion: Despite oral irritation, the ibuprofen gargle appeared to be safe and effective for the pain related to chemo- or CRT-induced oral mucositis. However, ibuprofen-related oral irritation warrants further formulation improvement. Trial registration: This study was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN000014433).
    2020, Journal of pharmaceutical health care and sciences, 6, 12 - 12, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hikaru Kubota, Kayoko Tsujino, Nor Shazrina Sulaiman, Shuhei Sekii, Yoko Matsumoto, Yosuke Ota, Toshinori Soejima, Satoshi Yamaguchi, Ryohei Sasaki
    BACKGROUND: Some studies have demonstrated that concurrent chemo-radiotherapy is an effective salvage treatment for isolated para-aortic lymph node (PALN) recurrence. However, no studies have compared multi-treatment modalities, such as radiation therapy (RT), concurrent chemoradiotherapy (CCRT), surgery, chemotherapy, and best supportive care (BSC), across a sufficient number of patients with PALN recurrence. We thus aimed to evaluate the clinical outcomes of multi-treatment modalities for isolated PALN recurrence in uterine cervical cancer. METHODS: Records of 50 patients who were first diagnosed with isolated PALN recurrence after definitive cervical cancer treatment from 2002 to 2016 at our institution were reviewed retrospectively. The initial definitive cervical cancer therapies included RT alone, CCRT, or surgery with or without post-operative RT. The median follow-up time was 33 months. The median age at recurrence diagnosis was 57 years (range, 26-84 years). The median duration between the end of initial treatment and recurrence was 10 months (range, 1-91 months). The median maximum metastatic lesion size was 17 mm (range, 8-60 mm). Twenty-four patients had one or two PALN metastases, while 26 had 3 or more. Eighteen patients were treated for recurrence with RT alone, seven with CCRT, three with surgery, 17 with chemotherapy, and five with BSC. Potential prognostic factors included histopathology, initial FIGO stage, initial treatment, age at recurrence, tumor markers (serum SCC-Ag and CEA) at recurrence, time to recurrence, maximum size of the metastatic lesion, number of metastases, and the recurrence treatment method. RESULTS: The 3-year overall survival (OS) rates of all patients were 47.0%. The 3-year OS rate of patients who underwent CCRT for recurrence was 85.7%; surgery, 66.7%; chemotherapy, 48.8%; RT, 41.3%; and BSC, 0% (p = 0.014). Univariate analysis revealed that only the recurrence treatment method was significantly associated with OS. The 3-year local control rate (LCR) and progression free survival (PFS) rate for CCRT were 100 and 71.4%; for surgery, 100 and 66.7%; for chemotherapy, 33.6 and 13.7%; and for RT, 55.5 and 14.1%, respectively (LCR: p = 0.028, PFS: p = 0.059). The number of metastatic lesions, SCC-Ag levels and recurrence treatment method were significantly associated with LCR. Age at recurrence, SCC-Ag levels, and number of metastatic lesions were significantly associated with PFS. CONCLUSIONS: Although our patient cohort size was small, our results suggest that CCRT may be effective in preventing local disease recurrence in the PALN and may improve OS.
    Dec. 2019, Radiation oncology (London, England), 14(1) (1), 236 - 236, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 【陽子線時代の小児がんに対するQOLを重視した放射線治療における工夫】吸収性スペーサー留置を併用した小児悪性腫瘍に対する粒子線治療
    佐々木 良平, 出水 祐介, 福本 巧
    (公大)京都府立医科大学, Dec. 2019, 京都府立医科大学雑誌, 128(12) (12), 889 - 896, Japanese

  • Shuhei Sekii, Kayoko Tsujino, Hikaru Kubota, Satoshi Yamaguchi, Kengo Kosaka, Shuichiro Miyazaki, Nor Shazrina Sulaiman, Yoko Matsumoto, Yosuke Ota, Toshinori Soejima, Ryohei Sasaki
    Our observational study aimed to verify the safety of our original titanium fiducial markers in gynecological cancer by using a simple insertion method. We prospectively evaluated the safety in patients with gynecological cancer who had undergone our insertion procedure of the titanium markers. The decision to implant a titanium marker was at the discretion of each radiation oncologist. The fiducial markers were manufactured by severing ligating clips for surgery into 3-6 mm pieces and were sterilized thereafter. We inserted an 18-gauge injection needle containing the marker before the marker was extruded by a 22-gauge Cattelan needle or shape memory alloy wire into the tumor or tissues close to the tumor. Severe complications within 3 months after implantation were scored according to the National Cancer Institute's Common Terminology Criteria for Adverse Events version 4.0. Between August 2016 and December 2018, we enrolled 46 patients. Of 46, 44 underwent implantation. The median age was 58.5 years. The most common primary site was the cervix. Two patients experienced detachment of the markers after implantation. No Grade 3 or higher level of complications was observed. Our simple insertion technique for original titanium fiducial markers was well-tolerated.
    Nov. 2019, Journal of radiation research, 60(6) (6), 844 - 848, English, International magazine
    [Refereed]
    Scientific journal

  • 新しい医療機器の開発と臨床応用 腹部悪性腫瘍に対する粒子線治療適応拡大を目指した新規素材吸収性スペーサーの開発
    小松 昇平, 木戸 正浩, 寺嶋 千貴, 出水 祐介, 津川 大介, 椋棒 英世, 蔵満 薫, 寺井 祥雄, 田中 基文, 柳本 泰明, 外山 博近, 味木 徹夫, 沖本 智昭, 佐々木 良平, 福本 巧
    日本臨床外科学会, Oct. 2019, 日本臨床外科学会雑誌, 80(増刊) (増刊), 339 - 339, Japanese
    [Refereed]

  • Ryohei Sasaki, Yusuke Demizu, Tomohiro Yamashita, Shohei Komatsu, Hiroaki Akasaka, Daisuke Miyawaki, Kenji Yoshida, Tianyuan Wang, Tomoaki Okimoto, Takumi Fukumoto
    PURPOSE: Surgical spacer placement (SSP) is useful in particle therapy (PT) for patients with abdominal or pelvic tumors located adjacent to normal organs. We developed a nonwoven fabric bioabsorbable spacer made of polyglycolic acid (PGA) sutures that degrades via hydrolysis. We then conducted this first-in-human phase 1 study of the combination of SSP and PT using the PGA spacer, which we termed space-making PT (SMPT). This study aimed to evaluate the safety and efficacy of SMPT in patients with unresectable malignant tumor located adjacent to normal organs. METHODS AND MATERIALS: The eligibility criteria included histologically proven malignant abdominal or pelvic tumor adjacent to the intestines, no metastasis, and no previous radiation therapy. Periodic computed tomography (CT) images were obtained before SSP and before, during, and after PT until the spacer disappeared. Treatment planning was performed for each CT image set until the end of PT, and doses for the planning target volume and organs at risk were analyzed. The thickness and volume of the PGA spacer were measured in each CT image set. Adverse events were evaluated according to the Common Terminology Criteria for Adverse Events version 4.0. RESULTS: Five patients were enrolled in this study. All patients received 70.4 Gy (relative biological effectiveness) of irradiation. V95% of the planning target volume before SSP, at the beginning of PT, and at the end of PT was 82.1% ± 11.3%, 98.1% ± 1.1%, and 97.1% ± 0.8%, respectively. The PGA spacers maintained enough thickness (≥1 cm) until the end of PT and disappeared within 8 months after SSP in all patients. No grade ≥3 acute adverse events were observed. CONCLUSIONS: The SMPT is feasible and useful for abdominal or pelvic tumors adjacent to the intestines. This method may be applicable to unresectable tumors located adjacent to normal organs and may expand the indications of PT.
    Elsevier BV, Oct. 2019, Advances in Radiation Oncology, 4(4) (4), 729 - 737, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yumi Muraki, Masaya Akashi, Yasuo Ejima, Takumi Hasegawa, Daisuke Miyawaki, Hirotaka Shinomiya, Mika Nishii, Naoki Otsuki, Ryohei Sasaki, Ken-Ichi Nibu, Takahide Komori
    BACKGROUND: The purpose of this study was to investigate the effectiveness of dental intervention before and after radiation therapy (RT) for head and neck malignancy on prevention of osteoradionecrosis (ORN) of the jaws. METHODS: This is a single-arm prospective study according to intervention protocol of prophylactic dental extraction before RT and routine follow-up after RT. The primary endpoint was the occurrence of jawbone exposure during the first 2 years after RT. RESULTS: Sixty-seven patients were assessed. Before RT, 144 teeth among 39 patients (58%) were prophylactically extracted. The occurrence of transient jawbone exposure during the first 2 years after RT was 7%. Because those jawbone exposures healed with intervention after RT, no jawbone exposure was found at 2 years after RT. CONCLUSIONS: Dental intervention both before and after RT seemed to be important to prevent ORN development. Further studies in larger cohorts are necessary.
    Sep. 2019, Oral and maxillofacial surgery, 23(3) (3), 297 - 305, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 放射線治療 QOLを考慮した局所治療 小児がんに対する吸収性スペーサー留置を併用した粒子線治療
    佐々木 良平, 出水 祐介, 岩田 宏満, 亀井 美智, 文野 誠久, 赤坂 浩亮, 王 天縁, 妹尾 悟史, 犬伏 祥子, 宮脇 大輔, 吉田 賢史, 小松 昇平, 福本 巧
    (一社)日本小児血液・がん学会, Sep. 2019, 日本小児血液・がん学会雑誌, 56(2) (2), 148 - 152, Japanese
    [Refereed]

  • Shohei Komatsu, Kazuki Terashima, Yoshiro Matsuo, Daiki Takahashi, Masaki Suga, Naoko Nishimura, Dongha Lee, Kentaro Tai, Masahiro Kido, Hirochika Toyama, Yusuke Demizu, Sunao Tokumaru, Tomoaki Okimoto, Ryohei Sasaki, Takumi Fukumoto
    Aug. 2019, Journal of surgical oncology, 120(2) (2), 214 - 222, English, International magazine
    [Refereed]
    Scientific journal

  • Nakayama M, Uehara K, Nishimura H, Tamura S, Munetomo Y, Tsudou S, Mayahara H, Mukumoto N, Geso M, Sasaki R
    Jul. 2019, Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology, 24(4) (4), 383 - 391
    [Refereed]

  • 腹部悪性腫瘍に対する粒子線治療適応拡大を可能とする新規素材吸収性スペーサーの開発と臨床応用
    小松 昇平, 木戸 正浩, 田中 基文, 外山 博近, 上野 公彦, 味木 徹夫, 出水 祐介, 沖本 智昭, 佐々木 良平, 福本 巧
    (一社)日本消化器外科学会, Jul. 2019, 日本消化器外科学会総会, 74回, P285 - 3, Japanese
    [Refereed]

  • Masanori Teshima, Naoki Otsuki, Hirotaka Shinomiya, Naruhiko Morita, Tatsuya Furukawa, Koichi Morimoto, Tetsu Nakamura, Kazunobu Hashikawa, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu
    OBJECTIVES: To evaluate the impact of retropharyngeal lymph node (RPLN) dissection in the surgical treatment of hypopharyngeal cancer. METHODS: Between 2007 and 2016, 98 previously untreated patients with pathological diagnosed hypopharyngeal squamous cell carcinoma underwent total pharyngolaryngectomy and bilateral neck dissection at Kobe University Hospital. Bilateral dissection of RPLN was simultaneously performed in all patients. Pharynx was reconstructed with free jejunal transfer in 94 patients and primarily closed in 4 patients. Postoperative chemoradiotherapy was performed in patients with high risk factors including metastasis to RPLN, multiple lymph node metastasis, extranodal invasion, and/or positive/close surgical margins. RESULTS: The median follow-up period was 25 months ranging from 1 to 105 months. RPLN adenopathy was preoperatively identified in 9 patients in FDG-positron emission tomography. All of them had pathologically diagnosed RPLN metastases, which had been controlled in all patients during the observation periods. Among the other 89 patients, 7 patients had RPLN metastasis. The 2-year overall survival rates of the patients with and without RPLN metastasis were 65.7% and 69.8% (P = .61), respectively. CONCLUSIONS: In the present study, patients with RPLN metastasis showed equally favorable oncological outcome compared with patients without RPLN metastasis. At least, ipsilateral RPLN dissection should be considered in the surgical treatment of advanced hypopharyngeal cancer and multiple neck lymph node metastasis regardless of primary subsite.
    Jun. 2019, Head & neck, 41(6) (6), 1738 - 1744, English, International magazine
    [Refereed]
    Scientific journal

  • Hiroki Kawaguchi, Kayoko Tsujino, Mayuko Miki, Yoko Matsumoto, Yosuke Ota, Koichi Hirokaga, Shintaro Takao, Toshinori Soejima, Ryohei Sasaki
    OBJECTIVE: To compare patient preferences and acute adverse events of hypofractionated (HF) and conventionally fractionated (CF) whole-breast irradiation (WBI) after breast-conserving surgery in our institution. METHODS: We conducted a patient preference study comparing CF-WBI (50 Gy/25 fractions) and HF-WBI (41.6 Gy/16 fractions) after breast-conserving surgery. Eligible patients selected either type of fractionation following an explanation from the radiation oncologist. In this report, we analyzed the selection rate and acute toxicities. RESULTS: Between June 2009 and December 2013, 348 patients (349 breasts) were identified as eligible for the study. Among them, 259 patients (260 breasts [74.5%]) selected CF-WBI and 89 patients (89 breasts [25.5%]) selected HF-WBI. Factors significantly associated with the selection of HF-WBI were older age (P = 0.028) and no adjuvant chemotherapy (P = 0.041). Regarding acute adverse events, Grade 2 (G2) or higher radiation dermatitis was less frequently observed in HF-WBI than in CF-WBI (13.8% vs. 29.4%; P = 0.004). In addition, G2 or higher breast pain was only observed in the CF-WBI group (6.9%; P = 0.012). There were no significant differences in the presence of fatigue, wound pain or radiation pneumonitis of G2 or higher between the groups. CONCLUSIONS: In this study, in which patients themselves selected the irradiation method, more patients tended to select CF-WBI. The frequency of G2 or higher dermatitis and breast pain was significantly lower in the HF-WBI group than in the CF-WBI group. Our results support the evidence for recommending HF-WBI after breast-conserving surgery while presenting aspects of patient preferences.
    Jun. 2019, Japanese journal of clinical oncology, 49(6) (6), 545 - 553, English, International magazine
    [Refereed]
    Scientific journal

  • 頭頸部癌に対する放射線治療後の放射線性顎骨壊死に関する検討
    窪田 光, 宮脇 大輔, 佐々木 香織, 妹尾 悟史, 井上 由子, 川口 弘毅, 西川 遼, 石原 武明, 吉田 賢史, 岸本 恵美, 明石 昌也, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 244 - 244, Japanese

  • 脊椎転移に対する手術療法の効果と限界
    角谷 賢一朗, 酒井 良忠, 由留部 崇, 高田 徹, 張 鍾頴, 宮崎 真吾, 垣内 裕司, 武岡 由樹, 神田 祐太郎, 辻本 龍, 河本 旭哉, 原 仁美, 深瀬 直政, 岡田 卓也, 坂下 明大, 佐々木 良平, 秋末 敏宏, 黒田 良祐, 西田 康太郎
    (一社)日本脊椎脊髄病学会, May 2019, Journal of Spine Research, 10(5) (5), 898 - 904, Japanese

  • Yasuyuki Shimizu, Naritoshi Mukumoto, Nelly Idrus, Hiroaki Akasaka, Sachiko Inubushi, Kenji Yoshida, Daisuke Miyawaki, Takeaki Ishihara, Yoshiaki Okamoto, Takahiro Yasuda, Makiko Nakahana, Ryohei Sasaki
    Apr. 2019, Advances in Radiation Oncology, 4(2) (2), 237 - 245
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Kisho Mori, Mitsuhiro Hirase, Takahiro Morishige, Eri Takano, Hirobumi Sunayama, Yukiya Kitayama, Sachiko Inubushi, Ryohei Sasaki, Masakazu Yashiro, Toshifumi Takeuchi
    Wiley, Feb. 2019, Angewandte Chemie, 131(6) (6), 1536 - 1536
    Scientific journal

  • Kisho Mori, Mitsuhiro Hirase, Takahiro Morishige, Eri Takano, Hirobumi Sunayama, Yukiya Kitayama, Sachiko Inubushi, Ryohei Sasaki, Masakazu Yashiro, Toshifumi Takeuchi
    Wiley, Feb. 2019, Angewandte Chemie International Edition, 58(6) (6), 1522 - 1522
    Scientific journal

  • YOSHIDA Aoi, KITAYAMA Yukiya, KIGUCHI Kentaro, YAMADA Takuya, AKASAKA Hiroaki, SASAKI Ryohei, TAKEUCHI Toshifumi
    American Chemical Society, Feb. 2019, Applied Bio Materials, 2(3) (3), 1177 - 1183, English
    [Refereed]
    Scientific journal

  • Kisho Mori, Mitsuhiro Hirase, Takahiro Morishige, Eri Takano, Hirobumi Sunayama, Yukiya Kitayama, Sachiko Inubushi, Ryohei Sasaki, Masakazu Yashiro, Toshifumi Takeuchi
    Feb. 2019, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 58(6) (6), 1612 - 1615, English
    [Refereed]
    Scientific journal

  • Hikaru Kubota, Toshinori Soejima, Nor Shazrina Sulaiman, Shuhei Sekii, Yoko Matsumoto, Yosuke Ota, Kayoko Tsujino, Ikuo Fujita, Takuya Fujimoto, Masayuki Morishita, Junichi Ikegaki, Koji Matsumoto, Ryohei Sasaki
    BACKGROUND: The selection of radiation therapy dose fractionation schedules for bone metastases is often based on the estimation of life expectancy. Therefore, accurate prognosis prediction is an important issue. It is reported that the Katagiri scoring system can be used to predict the survival of patients with bone metastases. We aimed to assess prognostic factors and validate the Katagiri scoring system in patients who were treated with radiation therapy for bone metastases. MATERIALS/METHODS: We retrospectively reviewed data of all patients who were treated with radiation therapy for bone metastases between 2004 and 2013. Age, sex, Karnofsky performance status (KPS), Eastern Cooperative Oncology Group performance status (ECOG PS), primary site (lesions and characteristics), visceral metastases, laboratory data, previous chemotherapy, and multiple bone metastases were analyzed for associations with overall survival (OS). Katagiri scores were calculated for each patient and were used to compare OS. RESULTS: Out of the 616 patients included in this analysis, 574 had died and 42 remained alive. The median follow-up time for survivors was 42 months. Univariate analysis revealed that age (P = 0.604) and multiple bone metastases (P = 0.691) were not significantly associated with OS. Multivariate analysis revealed that sex, ECOG PS, KPS, primary characteristics, visceral metastases, laboratory data, and previous chemotherapy were significantly associated with OS. The survival rates at 3, 6, 12, and 24 months, categorized by Katagiri score, were as follows: score 0-3, 94.4, 77.8, and 61.1%, respectively; score 4-6, 67.7, 48.7, and 31.2%, respectively; and score 7-10, 39.1, 22.1, and 9.0%, respectively (P < 0.001). CONCLUSION: Sex, ECOG PS, KPS, primary characteristics, visceral metastases, laboratory data, and previous chemotherapy were significant predictors of survival in patients with bone metastases. The Katagiri scoring system was significantly correlated with OS and can help us select the optimal dose-fractionation.
    Jan. 2019, Radiation oncology (London, England), 14(1) (1), 13 - 13, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiroaki Akasaka, Naritoshi Mukumoto, Masao Nakayama, Tianyuan Wang, Ryuichi Yada, Yasuyuki Shimizu, Sachiko Inubushi, Katsusuke Kyotani, Keisuke Okumura, Masanori Miyamoto, Ai Nakaoka, Kenta Morita, Yuya Nishimura, Chiaki Ogino, Ryohei Sasaki
    2019, Applied Nanoscience (Switzerland), 1 - 6, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Miki Takahashi, Nana Kosaka, Emi Wakui, Shinobu Iwaki, Mika Nishii, Masanori Teshima, Hirotaka Shinomiya, Koichi Morimoto, Naomi Kiyota, Ryohei Sasaki, Makoto Usami, Naoki Otsuki, Ken-Ichi Nibu
    BACKGROUND: Concomitant chemoradiotherapy (CCRT) produces severe mucositis and swallowing dysfunction, often resulting in malnutrition. Intensive nutrition support (INS) in addition to percutaneous endoscopic gastrostomy (PEG) is reported to decrease adverse effects during CCRT. PATIENTS AND METHODS: Fifty-eight patients with oropharyngeal cancer treated by CDDP-based CCRT were retrospectively analyzed. Twenty-nine patients treated with INS in addition to PEG were classified as INS group, and other 29 patients treated with PEG but without INS were classified as control group. RESULTS: INS in addition to PEG significantly increased calorie intake in the second half of CCRT and reduced adverse events including mucositis (p = 0.0019), leukopenia (p = 0.04), and renal function (p = 0.006). Moreover, 21 out of 29 patients had successfully administration of 200 mg/m2 or more of CDDP, while only 10 out of 29 patients had enough amount of CDDP in control group. CONCLUSIONS: These results suggest that INS in addition to prophylactic PEG not only decreases adverse effects but also may potentially improve oncological outcome of the patients with oropharyngeal cancer treated by CCRT.
    Dec. 2018, International journal of clinical oncology, 23(6) (6), 1023 - 1028, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Teraoka S, Kakei Y, Akashi Masaya, Iwata E, Hasegawa Takumi, Miyawaki Daisuke, Sasaki Ryohei, Komori Takahide
    Enhancing the antitumor effect of radiation, while reducing damage to organs, is a significant challenge in radiation therapy for head and neck malignancies. One promising radiosensitizer is gold. The present study aimed to determine whether gold nanoparticles (AuNPs) have the potential to enhance the effects of X-ray irradiation on head and neck cancer cells. The human head and neck carcinoma cell line HSC-3 was used. Total cell number and the levels of cell proliferation and apoptosis were compared between control cells and cells treated with 5-nm AuNPs alone at four concentrations (0.1, 0.4, 1.0 and 10.0 nM), X-ray irradiation alone at three doses (2, 4 and 8 Gy), or a combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs. Analysis of variance and Tukey-Kramer testing were performed to compare the different groups. The total number of cells significantly decreased following 4 and 8 Gy X-ray irradiation, compared with in the control group (control vs. 4Gy, P=2.19×10-4; control vs. 8Gy, P=1.28×10-6). The combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs significantly reduced the total number of cells compared with 4 Gy X-ray irradiation alone (P=2.95×10-4). Cell proliferation was not affected by AuNP treatment alone, 4 Gy X-ray irradiation alone or the combination of X-ray irradiation and AuNPs. The combination of 4 Gy irradiation and 1.0 nM AuNPs significantly increased the number of apoptotic cells compared with 4 Gy irradiation alone (P=0.0261). In conclusion, AuNPs combined with X-ray irradiation enhanced the cytotoxic effect on human head and neck cancer cells in vitro, through the induction of apoptosis, but not inhibition of cell proliferation.
    Nov. 2018, Biomed Rep, 9(5) (5), 415 - 420, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Shuhei Sekii, Kayoko Tsujino, Kengo Kosaka, Satoshi Yamaguchi, Hikaru Kubota, Yoko Matsumoto, Yosuke Ota, Ryohei Sasaki, Toshinori Soejima
    Purpose: In this paper, we report cases of two patients with vaginal tumor who underwent interstitial brachytherapy (ISBT), using three-dimensional (3D)-printed personalized templates designed inversely from computed tomography (CT) or magnetic resonance (MR) images. Material and methods: Patient 1 presenting with vaginal vault recurrence was planned to receive whole pelvis external beam radiotherapy (EBRT) followed by ISBT. The tumor invaded the paracolpium; thus, we planned to administer ISBT to include the tumor and vaginal membrane. A template was designed with holes for plastic needle applicator insertion considering the appropriate direction based on pre-treatment medical images. Patient 2 presenting with vaginal cancer was scheduled to receive EBRT and ISBT because of a paracolpium invasion. Before ISBT, MR imaging was performed with vaginal cylinder inserted in the patient's vagina. By measuring the length of the tumor manually and projecting the tumor orthogonally to a plane parallel to the bottom surface of the cylinder applicator, a template was designed. Computer-aided design software was used for planning both templates. Polycarbonate/acrylonitrile-butadiene-styrene resin was selected as material of the templates. Results: Patient 1 received 4-fraction ISBT one week apart. A mean of 10 applicators were inserted through the holes of the template in an average of 9 minutes (range, 5-15 minutes). All applicators were inserted toward the planned directions. Median minimum dose covering 90% (D90%) of the clinical target volume (CTV) was 634 cGy. Patient 2 underwent three-fraction irradiation twice daily at 6-hour interval. All applicators were inserted through the inside of the template. The median D90% of the CTV was 703 cGy. No grade 3 or higher toxicity were found in both series. Conclusions: 3D-printed templates designed using medical images are useful, especially for ISBT of vaginal tumors. Further verification of clinical indications, design of templates, and manufacturing process are needed.
    Oct. 2018, Journal of contemporary brachytherapy, 10(5) (5), 470 - 477, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takeaki Ishihara, Kazunari Yamada, Aya Harada, Haruhiro Yukiue, Masayuki Tanahashi, Hiroshi Niwa, Takashi Matsui, Koshi Yokomura, Yasuo Ejima, Ryohei Sasaki
    BACKGROUND: The adaptation criteria for administration of stereotactic body radiotherapy (SBRT) to patients with lung cancer who previously underwent surgery and subsequently developed a second primary lung cancer (SPLC) or intra-parenchymal lung metastasis (IPLM) are controversial, unlike the criteria for repeat surgery. We aimed to evaluate the feasibility of SBRT for these patients. Factors associated with decreased respiratory function were also evaluated. MATERIAL AND METHODS: Sixty-nine patients with 89 lesions who underwent SBRT between 2008 and 2017 were analyzed. Of these, 29 were diagnosed with SPLC while the remaining 40 had IPLM. The distribution of histological types was as follows: squamous cell carcinoma (n = 13 lesions); adenocarcinoma (n = 25); non-small cell carcinoma (n = 1); unknown histological type (n = 49). The prescribed doses to the planning target volume (PTV) were 50 Gy in five fractions for 85 lesions and 60 Gy in 10 fractions for four lesions at PTV mean. RESULTS: Over a median follow-up period of 55 months, the 4-year overall survival and local control rates were 50.3% and 87.6%, respectively. Six patients experienced grade 2 radiation pneumonitis and one experienced grade 3. Two patients experienced grade 5 pulmonary fibrosis. Decreased respiratory function was observed in 10 patients (15.1%). On multivariate analysis, the presence of pulmonary disease before SBRT was the only statistically significant factor associated with decreased respiratory function. CONCLUSIONS: SBRT is safe and feasible in patients with SPLC or IPLM previously treated surgically. Pre-existing pulmonary disease was a predictive factor for decreased respiratory function.
    Sep. 2018, Acta oncologica (Stockholm, Sweden), 57(9) (9), 1232 - 1239, English, International magazine
    [Refereed]
    Scientific journal

  • Sekii S, Ito Y, Harada K, Kitaguchi M, Takahashi K, Inaba K, Murakami N, Igaki H, Sasaki Ryohei, Itami J
    Sep. 2018, Rep Pract Oncol Radiother, 23(5) (5), 398 - 401, English, International magazine
    [Refereed]
    Scientific journal

  • Kishimoto M, Akashi Masaya, Kakei Y, Kusumoto J, Sakakibara A, Hasegawa Takumi, Furudoi Shungo, Sasaki Ryohei, Komori Takahide
    BACKGROUND: A problematic complication after radiation therapy is lymphedema. Development of lymphedema is associated with an increase in lymphatic paracellular permeability. The current study investigated the effects of radiation on intercellular junctions and paracellular permeability in cultured human dermal lymphatic endothelial cells (HDLECs). METHODS AND RESULTS: Double immunofluorescence staining with vascular endothelial (VE)-cadherin and actin immediately after X-ray irradiation (5 or 20 Gy) was performed. Morphological changes induced by irradiation were assessed. Cell viability and paracellular permeability after irradiation were also evaluated. Broad junctions in which VE-cadherin was accumulated at cell-cell contacts and almost colocalized with actin were significantly decreased in a dose-dependent manner in confluent and sparse irradiated HDLECs. Irradiation shortened the width of VE-cadherin-positive areas at the cell-cell contacts. Actin filaments did not colocalize with VE-cadherin after 20 Gy irradiation. Although cell viability was not affected by irradiation, paracellular permeability significantly increased in a dose-dependent manner. CONCLUSIONS: A dose of 5 or 20 Gy irradiation in HDLECs does not affect cell viability, but changes VE-cadherin mediated intercellular junctions and actin structure, resulting in an increase of paracellular permeability. Further investigations on the regulatory proteins involved in radiation-induced changes, which were observed in the current study, may contribute to development of lymphedema therapy.
    Aug. 2018, Lymphat Res Biol, 16(4) (4), 390 - 396, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Kenta Morita, Takahiro Suzuki, Yuya Nishimura, Kazuhisa Matsumoto, Chiya Numako, Kazuyoshi Sato, Masao Nakayama, Ryohei Sasaki, Chiaki Ogino, Akihiko Kondo
    Polyacrylic acid (PAA)-modified titanium peroxide nanoparticles (PAA-TiOx NPs) are promising radiosensitizers. PAA-TiOx NPs were synthesized from commercial TiO2 nanoparticles that were modified with PAA and functionalized by H2O2 treatment. To realize practical clinical uses for PAA-TiOx NPs, their tissue distribution and acute toxicity were evaluated using healthy mice and mice bearing tumors derived from xenografted MIAPaCa-2 human pancreatic cancer cells. Healthy mice were injected with PAA-TiOx NPs at 25 mg/kg body weight via the tail vein, and tumor-bearing mice were injected either into the tumor locally or via the tail vein. The concentration of PAA-TiOx NPs in major organs was determined over time using inductively coupled-plasma atomic emission spectrometry. After 1 h, 12% of the PAA-TiOx NP dose had accumulated in the tumor, and 2.8% of the dose remained after 1 week. Such high accumulation could be associated with enhanced permeability and retention effects of the tumor, as PAA-TiOx NPs are composed of inorganic particles and polymers, without tumor-targeting molecules. The liver accumulated the largest proportion of the injected nanoparticles, up to 42% in tumor-bearing mice. Blood biochemical parameters were also investigated after intravenous injection of PAA-TiOx NPs in healthy mice. PAA-TiOx NPs invoked a slight change in various liver-related biochemical parameters, but no liver injury was observed over the practical dose range. In the future, PAA-TiOx NPs should be modified to prevent accumulation in the liver and minimize risk to patients.
    Jul. 2018, Journal of bioscience and bioengineering, 126(1) (1), 119 - 125, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Eiji Iwata, Takumi Hasegawa, Takeshi Ueha, Daisuke Takeda, Izumi Saito, Teruya Kawamoto, Toshihiro Akisue, Yoshitada Sakai, Ryohei Sasaki, Ryosuke Kuroda, Takahide Komori
    Radiotherapy (RT) is one of the main treatment modalities for oral squamous cell carcinoma (OSCC), however, radioresistance is a major impediment to its clinical success and poses as a concern that needs to be addressed. Tumor hypoxia is known to be significantly associated with radioresistance in various malignancies, hence, resolving the hypoxic state of a tumor may improve the antitumor effect of RT on OSCC. We have previously revealed that transcutaneous CO2 induced mitochondrial apoptosis and suppressed tumor growth in OSCC by resolving hypoxia. Considering the previous study, we hypothesized that transcutaneous CO2 may enhance the antitumor effect of RT on OSCC by improving intratumoral hypoxia, thereby overcoming radioresistance. In the present study, the combination of transcutaneous CO2 and RT significantly inhibited tumor growth compared with other treatments. This combination therapy also led to decreased expression of HIF-1α in parallel with increased expression of the cleaved forms of caspase-3-8-9 and PARP, which play essential roles in mitochondrial apoptosis. Additionally, the combination therapy increased the expression of ROS modulator 1 and subsequent mitochondrial ROS production, compared to RT alone. These results indicated that transcutaneous CO2 could potentially improve the antitumor effect of RT by decreasing the intratumoral hypoxia and increasing the mitochondrial apoptosis. Our findings indicated that CO2 therapy may be a novel adjuvant therapy in combination with RT for OSCC.
    Jul. 2018, Oncology reports, 40(1) (1), 434 - 442, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Özgür Mehmet Avinçsal, Hirotaka Shinomiya, Naoki Otsuki, Ryohei Sasaki, Ken-ichi Nibu
    Background: Aggressive fibromatoses are histologically benign fibrous neoplasms originating from musculoaponeurotic structures throughout the body. They are locally invasive and erode adjacent vital structures. The head and neck region constitutes 7-25% of all extra-abdominal cases. Case Report: Here, we report the case of a patient with aggressive fibromatosis in the left side of the neck. While the tumor deeply invaded the scalene muscles, the lesion was successfully treated by surgery followed by radiotherapy. The patient has been disease free for the last 7 years following treatment. Conclusion: Due to its unusual location in the head and neck region, aggressive fibromatosis should be considered in the differential diagnosis of invading lesions of the neck.
    May 2018, Balkan medical journal, 35(3) (3), 278 - 281, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Ryo Nishikawa, Kenji Yoshida, Yasuhiko Ebina, Mayumi Omoteda, Daisuke Miyawaki, Takeaki Ishihara, Yasuo Ejima, Hiroaki Akasaka, Hitoaki Satoh, Katsusuke Kyotani, Satoru Takahashi, Ryohei Sasaki
    This study aimed to compare dosimetric parameters between non-optimized and optimized treatment planning (NOP and OP, respectively) of magnetic resonance imaging (MRI) -based intracavitary (IC) image-guided adaptive brachytherapy (IGABT) using the central shielding (CS) technique for cervical cancer. Fifty-three patients treated with external beam radiotherapy using CS and MRI-based IGABT with the IC approach alone were evaluated. The total high-risk clinical target volume (HR-CTV) D90 was aimed at >70 Gy equivalent dose in 2 Gy fractions (EQD2). In the small HR-CTV group (≤30 cm3), the mean D90s for NOP/OP were 98.6/80.7 Gy. In the large (30.1-40 cm3) and extensive (>40 cm3) HR-CTV groups, the mean D90s were 81.9/77.5 and 71.1/73.6 Gy, respectively. The mean D2cc values for organs at risks (OARs) in OP were acceptable in all groups, despite the high bladder D2cc in the NOP. The correlation between HR-CTV at first brachytherapy (BT) and NOP D90 was stronger than that between HR-CTV at first BT and OP D90. The targeted HR-CTV D90 and dose constraints of D2cc for OARs were both achieved in 16 NOP/47 OP patients for the bladder, 39/50 for the rectum, and 47/50 for the sigmoid colon (P < 0.001, P = 0.007, and P = 0.34, respectively). For small tumors, the role of optimization was to reduce the D2cc for OARs while maintaining the targeted D90. However, optimization was of limited value for extensive tumors. Methods of optimization in IGABT with CS for cervical cancer should be standardized while considering its effectiveness and limitations.
    May 2018, Journal of radiation research, 59(3) (3), 316 - 326, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Modified TALK Score for Japanese Patients with Laryngeal and Hypopharyngeal Cancers to Predict the Possibility of Laryngeal Preservation by Concurrent Chemoradiotherapy.
    Naoki Otsuki, Mio Matsui, Miki Takahashi, Ryohei Sasaki, Naomi Kiyota, Makoto Usami, Ken-Ichi Nibu
    OBJECTIVE: TALK score has been developed as an index for predicting the possibility of larynx preservation and prognosis of the patients with advanced laryngeal and hypopharyngeal cancers treated by concurrent chemoradiotherapy (CCRT). In this study, we validated the original TALK score in our clinical setting and modified the score for Japanese population. METHODS: The subjects were 21 patients with laryngeal cancer and 50 patients with hypopharyngeal cancer who underwent CCRT at Kobe University Hospital between April 2007 and August 2012. Data regarding T stage, serum albumin level just before treatment, maximum alcohol use, Karnofsky Performance Status (KPS), 3-year overall survival rate and 3-year larynx-preservation rate were collected from medical records. In the revised TALK score (JTALK), the following scoring criteria were modified to adjust Japanese population: T stage of the primary tumor (≥T3), serum albumin level (<3.5 g/dl), maximum alcohol use (≥one 350-ml can of beer/day or an equivalent amount), and KPS (<80%). RESULTS: The original TALK score was not significantly associated with the larynx preservation rates or survival rates for laryngeal cancer or hypopharyngeal cancer. Instead, JTALK score was significantly associated with the 3-year larynx preservation rates and 3-year survival rates of the patients with hypopharyngeal and laryngeal cancer. CONCLUSION: These results indicate that JTALK score could be a useful index for predicting the possibility of larynx preservation and prognosis of Japanese patients with advanced laryngeal and hypopharyngeal cancer treated by CCRT.
    Apr. 2018, The Kobe journal of medical sciences, 63(4) (4), E113-E122 - E122, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Mehmet Ozgur Avinçsal, Hirotaka Shinomiya, Masanori Teshima, Mie Kubo, Naoki Otsuki, Naomi Kyota, Ryohei Sasaki, Yoh Zen, Ken-Ichi Nibu
    BACKGROUND: The purpose of this research was to investigate the association between alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) polymorphisms and hypopharyngeal squamous cell carcinoma (SCC) survival. METHODS: We genotyped ADH1B (rs1229984) and ALDH2 (rs671) single nucleotide polymorphisms (SNPs) in 85 Japanese male patients with hypopharyngeal SCC. The independent prognostic values of ADH1B-ALDH2 genotypes were analyzed by univariate and multivariate proportional hazard Cox regression, taking well-known clinical risk factors into account. RESULTS: Heavy drinkers with ALDH2*2 allele resulted in significantly worse overall survival (OS; P = .028) and disease-free survival (DFS; P = .029) compared with other patients. Heavy drinkers with ALDH2*2 allele remained statistically significant in multivariate analysis for OS and DFS, indicating independent poor prognostic factor (hazard ratio [HR] 2.251; 95% confidence interval [CI] 1.018-4.975 and HR 2.261; 95% CI 1.021-5.006, respectively). CONCLUSION: We conclude that heavy drinkers with the ALDH2*2 allele are associated with poor outcome in hypopharyngeal SCC.
    Apr. 2018, Head & neck, 40(4) (4), 770 - 777, English, International magazine
    [Refereed]
    Scientific journal

  • Norihiro Aibe, Yusuke Demizu, Nor Shazrina Sulaiman, Yoshirou Matsuo, Masayuki Mima, Fumiko Nagano, Kazuki Terashima, Sunao Tokumaru, Tomokatsu Hayakawa, Masaki Suga, Takashi Daimon, Gen Suzuki, Yamazaki Hideya, Kei Yamada, Ryohei Sasaki, Nobukazu Fuwa, Tomoaki Okimoto
    PURPOSE: To evaluate the efficacy and safety of definitive proton beam therapy (PBT) for primary sacral chordoma. METHODS AND MATERIALS: We conducted a retrospective analysis of the clinical outcomes of eligible patients with primary sacral chordoma who had undergone definitive PBT with 70.4 Gy (relative biological effectiveness) in 32 fractions at our institution from September 2009 to October 2015. Local progression-free survival, distant metastasis-free survival, disease-free survival, cause-specific survival, and overall survival were evaluated. To explore the factors that influenced local progression, the following parameters were analyzed: sex, the presence of a spacer (Gore-Tex sheets), gross tumor volume, and extent of cranial tumor extension. Adverse events were evaluated using the Common Terminology Criteria for Adverse Events, version 4.0. To assess the impact of PBT on pain relief, the change in pain grades was investigated between the initiation of PBT and the last follow-up visit. RESULTS: Thirty-three eligible patients were analyzed. The median follow-up period was 37 months. The 3-year estimated local progression-free survival, distant metastasis-free survival, disease-free survival, cause-specific survival, and overall survival rates were 89.6%, 88.2%, 81.9%, 95.7%, and 92.7%, respectively. No significant association was between the patients' clinicopathologic characteristics and local progression-free survival. Four patients developed grade 3 adverse events, including acute dermatitis (n = 1), ileus (n = 1), and pain due to sacral insufficiency fractures (n = 2). The pain grades had improved, were unchanged, or had deteriorated in 15, 7, and 11 patients, respectively. CONCLUSIONS: Definitive PBT with 70.4 Gy (relative biological effectiveness) in 32 fractions is an effective treatment with acceptable toxicity for primary sacral chordoma and has the potential to reduce pain.
    Mar. 2018, International journal of radiation oncology, biology, physics, 100(4) (4), 972 - 979, English, International magazine
    [Refereed]
    Scientific journal

  • Masao Nakayama, Hideki Nishimura, Hiroshi Mayahara, Masaki Nakamura, Kazuyuki Uehara, Shinji Tsudou, Aya Harada, Hiroaki Akasaka, Ryohei Sasaki
    Elsevier Inc., Mar. 2018, Practical Radiation Oncology, 8(2) (2), e63 - e70, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 画像誘導小線源治療時の遺残腫瘍体積と腫瘍縮小率に基づく子宮頸癌患者のリスク分類(Risk Group Analyses in Cervical Cancer Patients Based on MRI at the Time of Image Guided Adaptive Brachytherapy)
    Nishikawa Ryo, Yoshida Kenji, Ebina Yasuhiko, Omoteda Mayumi, Ejima Yasuo, Miyawaki Daisuke, Ishihara Takeaki, Takahashi Satoru, Sasaki Ryohei
    (公社)日本医学放射線学会, Feb. 2018, 日本医学放射線学会学術集会抄録集, 77回, S255 - S255, English

  • Hiroaki Nagashima, Takashi Sasayama, Kazuhiro Tanaka, Katsusuke Kyotani, Naoko Sato, Masahiro Maeyama, Masaaki Kohta, Junichi Sakata, Yusuke Yamamoto, Kohkichi Hosoda, Tomoo Itoh, Ryohei Sasaki, Eiji Kohmura
    It is sometimes difficult to distinguish gliomas from other tumors on routine imaging. In this study, we assessed whether 3-T magnetic resonance spectroscopy (MRS) with LCModel software might be useful for discriminating glioma from other brain tumors, such as primary central nervous system lymphomas (PCNSLs) and metastatic tumors. A total of 104 cases of brain tumor (66 gliomas, 20 PCNSLs, 6 metastatic tumors, 12 other tumors) were preoperatively investigated with short echo time (35 ms) single-voxel 3-T MRS. LCModel software was used to evaluate differences in the absolute concentrations of choline, N-acetylaspartate, N-acetylaspartylglutamate, glutamate + glutamine, myo-inositol (mIns), and lipid. mIns levels were significantly increased in high-grade glioma (HGG) compared with PCNSL (p < 0.001). In multivariate logistic regression analysis, mIns was the best marker for differentiating HGG from PCNSL (p < 0.0001, odds ratio 1.9927, 95% confidence interval 1.3628-3.2637). Conventional MRS detection of mIns resulted in a high diagnostic accuracy (sensitivity, 64%; specificity, 90%; area under the receiver operator curve, 0.80) for HGG. The expression of inositol 3-phosphate synthase (ISYNA1) was significantly higher in gliomas than in PCNSLs (p < 0.05), suggesting that the increased level of mIns in glioma is due to high expression of ISYNA1, the rate-limiting enzyme in the mIns-producing pathway. In conclusion, noninvasive analysis of mIns using single-voxel MRS may be useful in distinguishing gliomas from other brain tumors, particularly PCNSLs.
    Jan. 2018, Journal of neuro-oncology, 136(2) (2), 317 - 326, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hirotaka Shinomiya, Hitomi Shinomiya, Mie Kubo, Yuki Saito, Masafumi Yoshida, Mizuo Ando, Masanori Teshima, Naoki Otsuki, Naomi Kiyota, Ryohei Sasaki, Kenichi Nibu
    Dec. 2017, PLOS ONE, 12(12) (12), e0187992, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Shohei Komatsu, Masahiro Kido, Sadaki Asari, Hirochika Toyama, Tetsuo Ajiki, Yusuke Demizu, Kazuki Terashima, Tomoaki Okimoto, Ryohei Sasaki, Takumi Fukumoto
    Dec. 2017, Surgery, 162(6) (6), 1241 - 1249, English, International magazine
    [Refereed]
    Scientific journal

  • Takeshi Fukumoto, Ryohei Sasaki, Ryuichi Yada, Susumu Fujiwara, Masanobu Sakaguchi, Masahiro Oka, Chikako Nishigori
    Nov. 2017, The Journal of dermatology, 44(11) (11), e272-e273 - E273, English, International magazine
    [Refereed]
    Scientific journal

  • Masaki Nakamura, Hideki Nishimura, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Naoki Hashimoto, Yasuo Ejima, Takeaki Ishihara, Ryo Nishikawa, Ryohei Sasaki
    Nov. 2017, Journal of radiation research, 58(6) (6), 834 - 839, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Kenichiro Kakutani, Yoshitada Sakai, Koichiro Maeno, Toru Takada, Takashi Yurube, Takuto Kurakawa, Shingo Miyazaki, Yoshiki Terashima, Masaaki Ito, Hitomi Hara, Teruya Kawamoto, Yasuo Ejima, Akihiro Sakashita, Naomi Kiyota, Yoshiyuki Kizawa, Ryohei Sasaki, Toshihro Akisue, Hironobu Minami, Ryosuke Kuroda, Masahiro Kurosaka, Kotaro Nishida
    STUDY DESIGN: A prospective cohort study of performance status (PS) and activities of daily living (ADL) in patients with spinal metastasis. OBJECTIVE: To identify the effect of spinal surgery on PS and ADL in patients with spinal metastasis. SUMMARY OF BACKGROUND DATA: Spinal metastasis causes severe neurological deficits, resulting in drastic loss of patients' PS and ADL. However, the effect of spine surgery on PS and ADL is not well known. MATERIALS AND METHODS: Seventy patients with spinal metastasis were enrolled in this study. Forty-six patients desired and underwent spine surgery ("surgery" group) and 24 patients did not desire surgery ("nonsurgery" group). Both groups received optimal treatments, including radiation, chemotherapy, and palliative care services. Evaluation was performed at 1, 3, and 6 months after study enrollment using the Eastern Cooperative Oncology Group PS, the Barthel index (BI) for ADL, and Frankel classification for neurological status. RESULTS: There was no significant difference in baseline PS, the BI, or Frankel classification between the groups. The surgery group showed significant improvement in PS, maintaining grade 2 or less throughout the duration of the study, as well as in ADL, exceeding 70 points of the BI, compared with the nonsurgery group (P<0.05). Significantly improved neurological condition was also observed in the surgery group over the following 6 months. More than 95% of patients who underwent surgery improved their PS, the BI, and neurological status. Furthermore, >80% of these patients maintained improvement in PS, the BI, and neurological status for at least 6 months. In contrast, PS, the BI, and neurological status of patients in the "nonsurgery" group deteriorated throughout the study period. CONCLUSIONS: Spine surgery improves PS, ADL, and neurological status in patients with spinal metastasis for a minimum 6 months. This indicates that these patients can acquire an independent daily life.
    Oct. 2017, Clinical spine surgery, 30(8) (8), E1026-E1032 - E1032, English, International magazine
    [Refereed]
    Scientific journal

  • Tianyuan Wang, Takeaki Ishihara, Atsushi Kono, Naoki Yoshida, Hiroaki Akasaka, Naritoshi Mukumoto, Ryuichi Yada, Yasuo Ejima, Kenji Yoshida, Daisuke Miyawaki, Kenichiro Kakutani, Kotaro Nishida, Noriyuki Negi, Toshiaki Minami, Yuuichi Aoyama, Satoru Takahashi, Ryohei Sasaki
    Jul. 2017, Physics in medicine and biology, 62(15) (15), 6226 - 6245, English, International magazine
    [Refereed]
    Scientific journal

  • 医学における放射線治療の現況
    Sasaki Ryohei, 長田雅昭
    Jul. 2017, Joncol: Japanese Journal of Veterinary Clinical Oncology, 13(2号) (2号), 61 - 66, Japanese
    [Refereed][Invited]
    Scientific journal

  • Shingo Miyazaki, Kenichiro Kakutani, Yoshitada Sakai, Yasuo Ejima, Koichiro Maeno, Toru Takada, Takashi Yurube, Yoshiki Terashima, Masaaki Ito, Yuji Kakiuchi, Yoshiki Takeoka, Hitomi Hara, Teruya Kawamoto, Akihiro Sakashita, Takuya Okada, Naomi Kiyota, Yoshiyuki Kizawa, Ryohei Sasaki, Toshihiro Akisue, Hironobu Minami, Ryosuke Kuroda, Kotaro Nishida
    Jun. 2017, INTERNATIONAL ORTHOPAEDICS, 41(6) (6), 1265 - 1271, English
    [Refereed]
    Scientific journal

  • Yusuke Demizu, Dongcun Jin, Nor Shazrina Sulaiman, Fumiko Nagano, Kazuki Terashima, Sunao Tokumaru, Takashi Akagi, Osamu Fujii, Takashi Daimon, Ryohei Sasaki, Nobukazu Fuwa, Tomoaki Okimoto
    PURPOSE: To retrospectively analyze the treatment outcomes of particle therapy using protons or carbon ions for unresectable or incompletely resected bone and soft tissue sarcomas (BSTSs) of the pelvis. METHODS AND MATERIALS: From May 2005 to December 2014, 91 patients with nonmetastatic histologically proven unresectable or incompletely resected pelvic BSTSs underwent particle therapy with curative intent. The particle therapy used protons (52 patients) or carbon ions (39 patients). All patients received a dose of 70.4 Gy (relative biologic effectiveness) in 32 fractions (55 patients) or 16 fractions (36 patients). RESULTS: The median patient age was 67 years (range 18-87). The median planning target volume (PTV) was 455 cm3 (range 108-1984). The histologic type was chordoma in 53 patients, chondrosarcoma in 14, osteosarcoma in 10, malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma in 5, and other in 9 patients. Of the 91 patients, 82 had a primary tumor and 9 a recurrent tumor. The median follow-up period was 32 months (range 3-112). The 3-year rate of overall survival (OS), progression-free survival (PFS), and local control was 83%, 72%, and 92%, respectively. A Cox proportional hazards model revealed that chordoma histologic features and a PTV of ≤500 cm3 were significantly associated with better OS, and a primary tumor and PTV of ≤500 cm3 were significantly associated with better PFS. Ion type and number of fractions were not significantly associated with OS, PFS, or local control. Late grade ≥3 toxicities were observed in 23 patients. Compared with the 32-fraction protocol, the 16-fraction protocol was associated with significantly more frequent late grade ≥3 toxicities (18 of 36 vs 5 of 55; P<.001). CONCLUSIONS: Particle therapy using protons or carbon ions was effective for unresectable or incompletely resected pelvic BSTS, and the 32-fraction protocol was effective and relatively less toxic. Nevertheless, a longer follow-up period is needed to confirm these results.
    Jun. 2017, International journal of radiation oncology, biology, physics, 98(2) (2), 367 - 374, English, International magazine
    [Refereed]
    Scientific journal

  • Shuhei Sekii, Naoya Murakami, Tomoyasu Kato, Ken Harada, Mayuka Kitaguchi, Kana Takahashi, Koji Inaba, Hiroshi Igaki, Yoshinori Ito, Ryohei Sasaki, Jun Itami
    Jun. 2017, Journal of contemporary brachytherapy, 9(3) (3), 209 - 215, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Natsuki Yonezawa, Tsutomu Minamikawa, Kazuhiro Kitajima, Yusuke Takahashi, Ryohei Sasaki, Ken-ichi Nibu, Takahide Komori
    May 2017, NAGOYA JOURNAL OF MEDICAL SCIENCE, 79(2) (2), 189 - 198, English
    [Refereed]
    Scientific journal

  • Kenji Yoshida, Nor Shazrina Sulaiman, Daisuke Miyawaki, Yasuo Ejima, Hideki Nishimura, Takeaki Ishihara, Yoshiro Matsuo, Ryo Nishikawa, Takashi Sasayama, Akira Hayakawa, Eiji Kohmura, Ryohei Sasaki
    Apr. 2017, Asia-Pacific journal of clinical oncology, 13(2) (2), e153-e160 - E160, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takeaki Ishihara, Kazuhiro Kitajima, Yuko Suenaga, Yasuo Ejima, Hirokazu Komatsu, Naoki Otsuki, Ken-ichi Nibu, Naomi Kiyota, Satoru Takahashi, Ryohei Sasaki
    Feb. 2017, NAGOYA JOURNAL OF MEDICAL SCIENCE, 79(1) (1), 27 - 36, English
    [Refereed]
    Scientific journal

  • 脊椎転移に対する集学的治療の予後改善効果
    Kakutani Kenichiro, Sakai Yoshitada, 前野耕一郎, 高田徹, 寺嶋良樹, 伊藤雅明, 垣内裕司, 武岡由樹, 江島泰生, Hara Hitomi, Okada Takuya, Sakashita Akihiro, Sasaki Ryohei, 秋末敏宏, Kuroda Ryosuke, 西田康太郎
    (一社)日本脊椎脊髄病学会, Feb. 2017, Journal of Spine Research, 8(2) (2), 139 - 146, Japanese
    [Refereed]
    Scientific journal

  • Natsuki Yonezawa, Tsutomu Minamikawa, Kazuhiro Kitajima, Yusuke Takahashi, Ryohei Sasaki, Ken-Ichi Nibu, Takahide Komori
    The aim of this study was to investigate the prognostic value of dual-time-point (DTP) 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging in primary oral tongue squamous cell carcinoma (OTSCC). The study included 52 patients who underwent preoperative 18F-FDG PET scans at two time points, namely 1 h and 2 h after injection. The following PET parameters were calculated: maximum standardized uptake value (SUVmax) for both time points (SUV early, SUV delayed); retention index (RI); and SUVmax increment (ΔSUVmax). Receiver operating characteristic (ROC) curve analysis was performed to define the optimal cutoff point for these parameters. Overall survival was calculated using the Kaplan-Meier method. Prognostic factors for patients with OTSCC were evaluated using the univariate log-rank test and a multivariate Cox proportional hazards model. ROC analysis revealed that the area under the curve was higher and more accurate for ΔSUVmax than for the other parameters. Additionally, patients with a ΔSUVmax ≥0.9 had significantly worse survival outcomes (28.9% vs 92.6%; p < 0.01). Univariate analysis showed that prognosis was significantly correlated with clinical T stage, local recurrence, perineural invasion, vascular invasion, and PET parameters (p < 0.05 for all). Multivariate analysis showed that local recurrence (hazard ratio = 3.60; p = 0.02) and ΔSUVmax (hazard ratio = 8.43; p < 0.01) were independent prognostic factors. ΔSUVmax determined using DTP 18F-FDG PET may be an additional prognostic factor in OTSCC patients.
    Feb. 2017, Nagoya journal of medical science, 79(2) (2), 189 - 198, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Takeaki Ishihara, Kazuhiro Kitajima, Yuko Suenaga, Yasuo Ejima, Hirokazu Komatsu, Naoki Otsuki, Ken-Ichi Nibu, Naomi Kiyota, Satoru Takahashi, Ryohei Sasaki
    This study evaluated the prognostic significance of the maximum standardized uptake value of the primary site (pSUVmax) in 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans of patients with oropharyngeal or hypopharyngeal cancer who were treated using definitive radiotherapy. The study included 86 patients who were primarily treated with radiotherapy for oropharyngeal or hypopharyngeal cancer. Sixty-nine patients underwent concurrent chemotherapy. The associations between pre-treatment pSUVmax and treatment outcomes were evaluated. The most appropriate pSUVmax cut-off value for predicting disease-free survival (DFS) and local control (LC) was selected using receiver operating characteristic (ROC) curves. The median follow-up time for surviving patients was 60 months, while the median survival time in the entire patient cohort was 55 months. A pSUVmax cut-off value of 9.0 showed the best discriminative performance. Five-year OS and DFS rates were 65.9% and 60.0%, respectively. In univariate analyses, pSUVmax (p = 0.009), T-stage (p = 0.001), N-stage (p = 0.039), and clinical stage (p = 0.017) were identified as significant prognostic predictors for DFS. The multivariate analysis did not identify any statistically significant factors, but the association between pSUVmax and DFS was borderline significant (p = 0.055). Interestingly, pSUVmax was predictive of local controllability in T1-T2 disease (p = 0.024), but there was no significant association for T3-T4 disease (p = 0.735). In this study, pSUVmax was predictive of DFS and LC in patients with oropharyngeal or hypopharyngeal cancer that was treated with definitive radiotherapy. pSUVmax was strongly associated with LC in T1-T2 disease.
    Feb. 2017, Nagoya journal of medical science, 79(1) (1), 27 - 36, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Yoshiaki Watanabe, Hiroaki Kurihara, Jun Itami, Ryohei Sasaki, Yasuaki Arai, Kazuro Sugimura
    Jan. 2017, Radiation oncology (London, England), 12(1) (1), 17 - 17, English, International magazine
    [Refereed]
    Scientific journal

  • Evaluation of a Small Animal Irradiation System for Animal Experiments Using EBT3 Model GAFCHROMIC Film
    SHIMIZU Yasuyuki, AKASAKA Hiroaki, MIYAWAKI Daisuke, MIYAWAKI Daisuke, MUKUMOTO Naritoshi, NAKAYAMA Masao, WANG Tianyuan, OSUGA Saki, INUBUSHI Sachiko, YADA Ryuichi, EJIMA Yasuo, YOSHIDA Kenji, YOSHIDA Kenji, ISHIHARA Takeaki, ISHIHARA Takeaki, SASAKI Ryohei, SASAKI Ryohei
    2017, Kobe Journal of Medical Sciences (Web), 63(3) (3), E84‐E91 (WEB ONLY), English

  • Naritoshi Mukumoto, Masao Nakayama, Hiroaki Akasaka, Yasuyuki Shimizu, Saki Osuga, Daisuke Miyawaki, Kenji Yoshida, Yasuo Ejima, Yasushi Miura, Keiji Umetani, Takeshi Kondoh, Ryohei Sasaki
    Jan. 2017, Journal of radiation research, 58(1) (1), 17 - 23, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Nobuhisa Takase, Kimihiro Yamashita, Yasuo Sumi, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Yoshiko Matsuda, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yu-Ichiro Koma, Masato Komatsu, Ryohei Sasaki, Yoshihiro Kakeji
    Jan. 2017, WORLD JOURNAL OF CLINICAL CASES, 5(1) (1), 18 - 23, English
    [Refereed]
    Scientific journal

  • Evaluation of a small animal irradiation system for animal experiments using EBT3 model GAFCHROMIC ™ film
    Yasuyuki Shimizu, Hiroaki Akasaka, Daisuke Miyawaki, Naritoshi Mukumoto, Masao Nakayama, Tianyuan Wang, Saki Osuga, Sachiko Inubushi, Ryuichi Yada, Yasuo Ejima, Kenji Yoshida, Takeaki Ishihara, Ryohei Sasaki
    Jan. 2017, Kobe Journal of Medical Sciences, 63(3) (3), E84 - E91, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Tomoko Kataoka, Naomi Kiyota, Takanobu Shimada, Yohei Funakoshi, Naoko Chayahara, Masanori Toyoda, Yutaka Fujiwara, Ken-Ichi Nibu, Takahide Komori, Ryohei Sasaki, Toru Mukohara, Hironobu Minami
    OBJECTIVE: Radiation-induced mucositis (RIM) in chemoradiotherapy (CRT) for head and neck cancer (HNC) causes severe pain and worsens CRT compliance, QOL and outcome. Following retrospective reports, we conducted a randomized trial of the safety and efficacy of gabapentin for RIM-associated pain during CRT. METHODS: HNC patients (pts) receiving CRT were randomized to standard pain control (SPC) with acetaminophen and opioids, or SPC plus gabapentin (SPC+G). Gabapentin was maintained at 900mg/day for 4 weeks after CRT. Primary endpoint was maximum visual analogue scale (VAS) score during CRT, and secondary endpoints were total opioid dose, changes in QOL (EORTC QLQ-C30 and QLQ-HN 35) from baseline to 4 weeks after CRT, and adverse events. RESULTS: Twenty-two eligible Stage III or IV pts were randomly assigned to SPC or SPC+G (n=11 each). Twelve were treated in a locally advanced setting and 10 in a postoperative setting. Median maximum VAS scores, median total dose of opioids at maximum VAS and total dose of opioids at 4 weeks after CRT tended to be higher in the SPC+G arm (47 in SPC vs. 74 in SPC+G, p=0.517; 215mg vs. 745.3mg, p=0.880; and 1260mg vs. 1537.5mg, p=0.9438, respectively), without significance. QOL analysis showed significantly worse scores in the SPC+G arm for weight gain (p=0.005). Adverse events related to gabapentin were manageable. CONCLUSIONS: This pilot study is the first prospective randomized trial of gabapentin for RIM-related pain. Gabapentin had no apparent beneficial effect. Further research into agents for RIM-related pain is warranted.
    Dec. 2016, Auris, nasus, larynx, 43(6) (6), 677 - 84, English, International magazine
    [Refereed]
    Scientific journal

  • Shuko Takahashi, Yuki Yonekura, Ryohei Sasaki, Yukari Yokoyama, Kozo Tanno, Kiyomi Sakata, Akira Ogawa, Seichiro Kobayashi, Taro Yamamoto
    Dec. 2016, PLOS ONE, 11(12) (12), e0166817, English
    [Refereed]
    Scientific journal

  • 当院における再発転移頭頸部扁平上皮癌に対する初回化学療法としてのセツキシマブ併用療法の遡及的検討
    今村善宣, 清田尚臣, 大月直樹, 森本浩一, 四宮弘隆, 江島泰生, 南川勉, Sasaki Ryohei, 丹生健一
    (一社)日本頭頸部癌学会, Dec. 2016, 頭頸部癌, 42(4) (4), 432 - 437, Japanese
    [Refereed]
    Scientific journal

  • Hikari Shimoda, Koichiro Yonezawa, Hirotaka Shinomiya, Naoki Otsuki, Kazunobu Hashikawa, Ryohei Sasaki, Eiji Komura, Ken-ichi Nibu
    Dec. 2016, HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 38(12) (12), E2519 - E2522, English
    [Refereed]
    Scientific journal

  • Masaki Nakamura, Hideki Nishimura, Masao Nakayama, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Naoki Hashimoto, Yasuo Ejima, Takeaki Ishihara, Ryohei Sasaki
    OBJECTIVE: The aims of this study were to investigate the frequency of symptomatic radiation pneumonitis (RP) after CyberKnife lung stereotactic body radiotherapy (SBRT) and to evaluate predictive factors of symptomatic RP. METHODS: 56 patients with peripheral non-small-cell lung cancer were treated using the CyberKnife® VSI™ System (Accuracy Inc., Sunnyvale, CA) between May 2013 and September 2015. Total radiation doses ranged from 48 to 56 Gy, as delivered in four equal fractions. Symptomatic RP was defined as a grade of ≥2. Predictive factors for symptomatic RP were evaluated using univariate and multivariate analyses. RESULTS: With a median follow-up duration of 12.5 months (range, 3-27 months), symptomatic RP was observed in 6 (10.7%) of the 56 patients. In the univariate analysis, percent vital capacity (p < 0.05), maximum tumour diameter (p < 0.05), gross tumour volume (p < 0.05), planning target volume (p < 0.01), mean lung dose (p < 0.01) and a normal lung volume receiving 5-50 Gy of radiation (V5-50) (p < 0.01) were identified as significant predictive factors for symptomatic RP. In the multivariate analysis, only a V25 >3.4% (p = 0.011) was identified as a significant predictive factor of symptomatic RP. CONCLUSION: The incidence of symptomatic RP after CyberKnife SBRT was almost identical to the incidences reported in the linear accelerator-based SBRT. A significant association was observed between a V25 >3.4% and the risk of developing symptomatic RP. Advances in knowledge: This is the first report that has investigated prognostic factors for symptomatic RP after CyberKnife SBRT for lung cancer. The newly developed scoring system may help to predict symptomatic RP.
    Dec. 2016, The British journal of radiology, 89(1068) (1068), 20160560 - 20160560, English, International magazine
    [Refereed]
    Scientific journal

  • Kenta Morita, Serika Miyazaki, Chiya Numako, Shinya Ikeno, Ryohei Sasaki, Yuya Nishimura, Chiaki Ogino, Akihiko Kondo
    Dec. 2016, FREE RADICAL RESEARCH, 50(12) (12), 1319 - 1328, English
    [Refereed]
    Scientific journal

  • Satoshi Wanifuchi, Masaya Akashi, Yasuo Ejima, Hirotaka Shinomiya, Tsutomu Minamikawa, Shungo Furudoi, Naoki Otsuki, Ryohei Sasaki, Ken-Ichi Nibu, Takahide Komori
    PURPOSE: This retrospective study aimed to analyze the relationship between tooth extraction and osteoradionecrosis (ORN) occurrence. The irradiation field, dose, and time interval between radiotherapy (RT) and ORN were reviewed. We also discuss appropriate guidelines for prophylactic tooth extraction. METHODS: A total of 33 patients treated for grade ≥2 (clinical) ORN in our department from 2002 to 2014 were enrolled. The following epidemiological data were retrospectively gathered: age, sex, histological diagnosis, primary tumor sites, radiation dose, chemotherapy, site of ORN, relationship between tooth extraction and ORN occurrence, and time interval between tooth extraction and the initiation or end of RT. RESULTS: Twenty-one percent of ORN cases resulted from tooth extraction. The most common site of ORN (82 %) was the mandibular molar region. About half of ORN cases (49 %) occurred within 2 years after RT. All patients who received tooth extraction after RT developed ORN (100 %) independently of time interval between tooth extraction and the end of RT (median interval, 37.5 months; range, 27-120 months). In contrast, only 50 % of patients who received tooth extraction before RT developed ORN. There may have been an association between the irradiation field and the site of ORN development CONCLUSIONS: ORN occurrence due to tooth extraction was 21 %. Occurrence timing of ORN did not depend on time interval between tooth extraction and the end of RT. The irradiation field is certainly related to the site of ORN; therefore, prophylactic tooth extraction should be performed in consideration of the proposed radiation field and dose.
    Dec. 2016, Oral and maxillofacial surgery, 20(4) (4), 337 - 342, English, International magazine
    [Refereed]
    Scientific journal

  • Hiroaki Akasaka, Yoshiyuki Mizushina, Kenji Yoshida, Yasuo Ejima, Naritoshi Mukumoto, Tianyuan Wang, Sachiko Inubushi, Masao Nakayama, Yuki Wakahara, Ryohei Sasaki
    BACKGROUND: In our previous study, monogalactosyl diacylglycerol (MGDG) purified from spinach was found to have cytotoxic effects in human cancer cell lines. This study further assessed whether MGDG can enhance the cytotoxic effects of radiation in human pancreatic cancer cells in vitro and in vivo. METHODS: Glycoglycerolipids from spinach including MGDG were extracted from dried spinach. The cytotoxicity of MGDG were evaluated by the MTT assay using four human pancreatic cancer cell lines (MIAPaCa-2, AsPC-1, BxPC-3 and PANC-1) and normal human dermal fibroblasts (NHDFs). The effects of radiation and MGDG alone or in combination in MIAPaCa-2 cells was analyzed with the colony forming and apoptosis assays, western blotting and cell cycle and DNA damage analyses (γ-H2AX foci staining and comet assay). The inhibitory effects on tumor growth were assessed in a mouse xenograft tumor model. RESULTS: MGDG showed dose- and time-dependent cytotoxicity, with half-maximal inhibitory concentrations (IC50) in PANC-1, BxPC-3, MIAPaCa-2 and AsPC-1 cells at 72 h of 25.6 ± 2.5, 26.9 ± 1.3, 18.5 ± 1.7, and 22.7 ± 1.9 μM, respectively. The colony forming assay revealed fewer MIAPaCa-2, BxPC-3 and AsPC-1 cell colonies upon treatment with both MGDG and radiation as compared to irradiation alone (P < 0.05). The combination of MGDG and radiation induced a higher proportion of apoptosis in MIAPaCa-2 cells; this effect was associated with increased mitochondrial release of cytochrome c and activation of cleaved poly (ADP-ribose) polymerase and caspase-3. DNA damage was detected and DNA repair mechanisms were more frequently impaired in cells receiving the combination treatment as compared to either one alone. Tumor growth was inhibited to a greater degree in mice treated by intratumoral injection of MGDG combined with irradiation as compared to either one alone (P < 0.05). CONCLUSIONS: This is the first report demonstrating that MGDG enhances the cytotoxicity of radiation to induce apoptosis of cancer cells in vitro and in vivo. Our findings indicate that this therapeutic combination can be an effective strategy for the treatment of pancreatic cancer.
    Nov. 2016, Radiation oncology (London, England), 11(1) (1), 153 - 153, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiroaki Nagashima, Kazuhiro Tanaka, Takashi Sasayama, Yasuhiro Irino, Naoko Sato, Yukiko Takeuchi, Katsusuke Kyotani, Akitake Mukasa, Katsu Mizukawa, Junichi Sakata, Yusuke Yamamoto, Kohkichi Hosoda, Tomoo Itoh, Ryohei Sasaki, Eiji Kohmura
    Nov. 2016, NEURO-ONCOLOGY, 18(11) (11), 1559 - 1568, English
    [Refereed]
    Scientific journal

  • Yoshiro Matsuo, Kenji Yoshida, Hideki Nishimura, Yasuo Ejima, Daisuke Miyawaki, Haruka Uezono, Takeaki Ishihara, Hiroshi Mayahara, Takumi Fukumoto, Yonson Ku, Masato Yamaguchi, Koji Sugimoto, Ryohei Sasaki
    This study aimed to evaluate the efficacy of stereotactic body radiotherapy (SBRT) compared with three-dimensional conformal radiotherapy (3DCRT). Forty-three patients with portal vein tumor thrombosis (PVTT)/inferior vena cava tumor thrombosis (IVCTT) treated with SBRT (27 with CyberKnife (CK) and 16 with TrueBeam (TB)) from April 2013 to December 2014, and 54 treated with 3DCRT from June 2008 to March 2013 were evaluated. Dosimetric parameters, response to radiotherapy (RT) and survival outcomes were compared in total SBRT vs. 3DCRT, CK vs. 3DCRT and TB vs. 3DCRT, respectively. The median biologically effective dose 10 (BED10) values in total SBRT, CK, TB and 3DCRT were 73.4 Gy10, 75.0 Gy10, 60.5 Gy10 and 58.5 Gy10, respectively (P < 0.001 in total SBRT vs. 3DCRT, P < 0.001 in CK vs. 3DCRT, P = 0.004 in TB vs. 3DCRT). The tumor response rates were 67%, 70%, 62% and 46%, respectively (P = 0.04, P = 0.04, P = 0.25). The 1-year overall survival rates were 49.3%, 56.7%, 38.1% and 29.3%, respectively (P = 0.02, P = 0.02, P = 0.30), and the 1-year local progression rates were 20.4%, 21.9%, 18.8% and 43.6%, respectively (P = 0.01, P = 0.04, P = 0.10). The use of SBRT made it possible to achieve a higher BED10 compared with the use of 3DCRT. Improvements in local control and survival were achieved in the CK group and the total SBRT group. Our results suggest that SBRT may have the potential to be the standard RT technique for the treatment of PVTT/IVCTT.
    Sep. 2016, Journal of radiation research, 57(5) (5), 512 - 523, English, International magazine
    [Refereed]
    Scientific journal

  • Masao Nakayama, Ryohei Sasaki, Chiaki Ogino, Tsutomu Tanaka, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Zhenquan Tan, Yuya Nishimura, Hiroaki Akasaka, Kazuyoshi Sato, Chiya Numako, Seiichi Takami, Akihiko Kondo
    BACKGROUND: Biological applications of nanoparticles are rapidly increasing, which introduces new possibilities to improve the efficacy of radiotherapy. Here, we synthesized titanium peroxide nanoparticles (TiOxNPs) and investigated their efficacy as novel agents that can potently enhance the effects of radiation in the treatment of pancreatic cancer. METHODS: TiOxNPs and polyacrylic acid-modified TiOxNPs (PAA-TiOxNPs) were synthesized from anatase-type titanium dioxide nanoparticles (TiO2NPs). The size and morphology of the PAA-TiOxNPs was evaluated using transmission electron microscopy and dynamic light scattering. The crystalline structures of the TiO2NPs and PAA-TiOxNPs with and without X-ray irradiation were analyzed using X-ray absorption. The ability of TiOxNPs and PAA-TiOxNPs to produce reactive oxygen species in response to X-ray irradiation was evaluated in a cell-free system and confirmed by flow cytometric analysis in vitro. DNA damage after X-ray exposure with or without PAA-TiOxNPs was assessed by immunohistochemical analysis of γ-H2AX foci formation in vitro and in vivo. Cytotoxicity was evaluated by a colony forming assay in vitro. Xenografts were prepared using human pancreatic cancer MIAPaCa-2 cells and used to evaluate the inhibition of tumor growth caused by X-ray exposure, PAA-TiOxNPs, and the combination of the two. RESULTS: The core structures of the PAA-TiOxNPs were found to be of the anatase type. The TiOxNPs and PAA-TiOxNPs showed a distinct ability to produce hydroxyl radicals in response to X-ray irradiation in a dose- and concentration-dependent manner, whereas the TiO2NPs did not. At the highest concentration of TiOxNPs, the amount of hydroxyl radicals increased by >8.5-fold following treatment with 30 Gy of radiation. The absorption of PAA-TiOxNPs enhanced DNA damage and resulted in higher cytotoxicity in response to X-ray irradiation in vitro. The combination of the PAA-TiOxNPs and X-ray irradiation induced significantly stronger tumor growth inhibition compared to treatment with either PAA-TiOxNPs or X-ray alone (p < 0.05). No apparent toxicity or weight loss was observed for 43 days after irradiation. CONCLUSIONS: TiOxNPs are potential agents for enhancing the effects of radiation on pancreatic cancer and act via hydroxyl radical production; owing to this ability, they can be used for pancreatic cancer therapy in the future.
    Jul. 2016, Radiation oncology (London, England), 11(1) (1), 91 - 91, English, International magazine
    [Refereed]
    Scientific journal

  • 子宮頸癌に対するMRIガイド下画像誘導小線源治療の初期経験
    吉田賢史, 蝦名康彦, Miyawaki Daisuke, 松尾佳朗, 西川遼, 赤坂浩亮, 表田真弓, 京谷勉輔, 大田文江, 佐藤仁昭, 高橋哲, 山田秀人, Sasaki Ryohei
    (公社)日本婦人科腫瘍学会, Jun. 2016, 日本婦人科腫瘍学会雑誌, 34(3号) (3号), 494 - 494, Japanese
    [Refereed]
    Research society

  • Takeaki Ishihara, Kazunari Yamada, Aya Harada, Kenta Isogai, Yoshihiro Tonosaki, Yusuke Demizu, Daisuke Miyawaki, Kenji Yoshida, Yasuo Ejima, Ryohei Sasaki
    AIM: To evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy (HSRT) for brain metastases (BMs) from lung cancer, and to explore prognostic factors associated with local control (LC) and indication. PATIENTS AND METHODS: We evaluated patients who were treated with linac-based HSRT for BMs from lung cancer. Lesions treated with stereotactic radiosurgery (SRS) in the same patients during the same periods were analysed and compared with HSRT in terms of LC or toxicity. There were 53 patients with 214 lesions selected for this analysis (HSRT: 76 lesions, SRS: 138 lesions). For HSRT, the median prescribed dose was 35 Gy in 5 fractions. RESULTS: The 1‑year LC rate was 83.6 % in HSRT; on multivariate analysis, a planning target volume (PTV) of <4 cm(3), biologically effective dose (BED10) of ≥51 Gy, and adenocarcinoma were significantly associated with better LC. Moreover, in PTVs ≥ 4 cm(3), there was a significant difference in LC between BED10 < 51 Gy and ≥ 51 Gy (p = 0.024). On the other hand, in PTVs < 4 cm(3), both HSRT and SRS had good LC with no significant difference (p = 0.195). Radiation necrosis emerged in 5 of 76 lesions (6.6 %) treated with HSRT and 21 of 138 (15.2 %) lesions treated with SRS (p = 0.064). CONCLUSION: Linac-based HSRT was safe and effective for BMs from lung cancer, and hence might be particularly useful in or near an eloquent area. PTV, BED10, and pathological type were significant prognostic factors. Furthermore, in BMs ≥ 4 cm(3), a dose of BED ≥ 51 Gy should be considered.
    Jun. 2016, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 192(6) (6), 386 - 93, English, International magazine
    [Refereed]
    Scientific journal

  • [Radiotherapy with androgen deprivation for localized prostate cancer].
    Kenji Yoshida, Daisuke Miyawaki, Yasuyuki Shimizu, Ryo Nishikawa, Ryohei Sasaki
    May 2016, Nihon rinsho. Japanese journal of clinical medicine, 74 Suppl 3, 503 - 7, Japanese, Domestic magazine
    [Refereed]
    Scientific journal

  • 鼻腔腫瘍に対する放射線治療の経験
    西川遼, 吉田賢史, Miyawaki Daisuke, 石原武明, 井上由子, 松尾圭朗, ノル・シャズリナ, 江島泰生, 大月直樹, 丹生健一, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2号) (2号), 207 - 207, Japanese
    [Refereed]
    Research society

  • 同時併用化学放射線療法を施行した進行期喉頭癌、下咽頭癌症例におけるTalk Scoreの検討
    高橋美貴, 松井美緒, 涌井絵美, 清田尚臣, Sasaki Ryohei, 大月直樹, 宇佐美眞, 丹生健一
    May 2016, 頭頸部癌, 42(2号) (2号), 181, Japanese
    Research society

  • 当科で放射線治療を施行した下咽頭癌T1・T2症例の検討
    古川竜也, 大月直樹, 四宮弘隆, 小松弘和, 森本浩一, 清田尚臣, Sasaki Ryohei, 丹生健一
    May 2016, 頭頸部癌, 42(2号) (2号), 181, Japanese
    Research society

  • 舌癌術後再発症例に対する放射線治療成績
    Miyawaki Daisuke, 江島泰生, 吉田賢史, 石原武明, 西川遼, 清田尚臣, 南川勉, 大月直樹, 丹生健一, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2号) (2号), 207 - 207, Japanese
    [Refereed]
    Research society

  • セツキシマブ追加の有無による、再発性/転移性頭頸部癌の第一選択治療の比較(First-line Treatment of Recurrent/Metastatic Head and Neck Cancer with or without Cetuximab)
    今村 善宣, 清田 尚臣, 大月 直樹, 森本 浩一, 四宮 弘隆, 江島 泰生, 吉田 賢史, 南川 勉, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2) (2), 211 - 211, English
    Research society

  • Yuko Suenaga, Kazuhiro Kitajima, Takeaki Ishihara, Ryohei Sasaki, Naoki Otsuki, Ken-ichi Nibu, Tsutomu Minamikawa, Naomi Kiyota, Kazuro Sugimura
    Apr. 2016, EUROPEAN RADIOLOGY, 26(4) (4), 1018 - 1030, English
    [Refereed]
    Scientific journal

  • Hirotaka Shinomiya, Shingo Hasegawa, Daisuke Yamashita, Yasuo Ejima, Yoshida Kenji, Naoki Otsuki, Naomi Kiyota, Shunsuke Sakakibara, Tadashi Nomura, Kazunobu Hashikawa, Eiji Kohmura, Ryohei Sasaki, Ken-Ichi Nibu
    BACKGROUND: The purpose of this study was to analyze outcomes for the treatment of locally advanced temporal bone cancer by means of concomitant chemoradiotherapy (CCRT) with a combination of cisplatin (CDDP), 5-fluorouracil (5-FU), and docetaxel (TPF). METHODS: Between 2006 and 2011, 34 patients with squamous cell carcinoma of the temporal bone were treated at Kobe University Hospital. Medical records were retrospectively reviewed to obtain information concerning patient characteristics, extent of disease, treatment, adverse events, and oncologic results. RESULTS: Ten patients were treated with CCRT using TPF regimen. The 5-year overall survival rate and disease-free survival rate were both 60%. Of special interest is that even for patients with unresectable T4 disease, the 5-year overall survival rate was 56%. CONCLUSION: The results of our study indicate that CCRT with TPF for locally advanced temporal bone cancer is an effective and promising regimen. © 2015 Wiley Periodicals, Inc. Head Neck 38: E949-E953, 2016.
    Apr. 2016, Head & neck, 38 Suppl 1, E949-53 - 53, English, International magazine
    [Refereed]
    Scientific journal

  • Yuko Suenaga, Kazuhiro Kitajima, Tomonori Kanda, Naoki Otsuki, Ken-ichi Nibu, Ryohei Sasaki, Tomoo Itoh, Kazuro Sugimura
    Mar. 2016, JAPANESE JOURNAL OF RADIOLOGY, 34(3) (3), 203 - 210, English
    [Refereed]
    Scientific journal

  • 乳癌経過中に癌性髄膜炎との鑑別に苦慮したクリプトコッカス髄膜炎の1例
    浦瀬靖代, Miyawaki Daisuke, 江島泰生, 吉田賢史, 上薗玄, 石原武明, 西川遼, ノル・シャズリナ, 松尾圭朗, Sasaki Ryohei
    (公社)日本医学放射線学会, Feb. 2016, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 54 - 54, Japanese
    [Refereed]
    Research society

  • 限局性前立腺癌に対する永久刺入小線源単独治療の経験
    妹尾悟史, 吉田賢史, Miyawaki Daisuke, ノル・シャズリナ, 松尾圭朗, 赤坂浩亮, 上薗玄, 江島泰生, Sasaki Ryohei
    (公社)日本医学放射線学会, Feb. 2016, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 54 - 54, Japanese
    [Refereed]
    Research society

  • Yoshinori Imamura, Naomi Kiyota, Naoki Otsuki, Koichi Morimoto, Hirotaka Shinomiya, Yasuo Ejima, Tsutomu Minamikawa, Ryohei Sasaki, Ken-Ichi Nibu
    Japan Society for Head and Neck Cancer, 2016, Japanese Journal of Head and Neck Cancer, 42(4) (4), 432 - 437, Japanese
    [Refereed]
    Scientific journal

  • A dosimetric comparison of Volumetric Modulated Arc Therapy (VMAT) with unflattened beams to VMAT with Flattened Beams and Tomotherapy for head and neck cancer
    T Ogata, H Nishimura, H Mayahara, A Harada, Y Matsuo, M Nakayama, K Uehara, S Tsudou, Y Ejima, R Sasaki, T Okayama
    Jan. 2016, J Nucl Med Radiat Ther, 7(1) (1)
    [Refereed]

  • 70歳以上脊椎転移に対する手術成績
    Kakutani Kenichiro, 酒井良忠, Maeno Koichiro, 高田徹, 由留部崇, 蔵川拓外, 宮崎真吾, 寺島良樹, 伊藤雅明, Ejima Yasuo, Hara Hitomi, Sakashita Akihiro, Sasaki Ryohei, 秋末敏宏, 黒坂昌弘, Nishida Kotaro
    (一社)日本脊椎脊髄病学会, Jan. 2016, Journal of Spine Research, 7(1) (1), 25 - 30, Japanese
    [Refereed]
    Scientific journal

  • Hitomi Shinomiya, Naoki Otsuki, Daisuke Yamashita, Hirotaka Shinomiya, Masanori Teshima, Yasuo Ejima, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu
    Japan Society for Head and Neck Cancer, 2016, Japanese Journal of Head and Neck Cancer, 42(1) (1), 51 - 56, Japanese
    [Refereed]
    Scientific journal

  • Kenji Yoshida, Noha Jastaniyah, Alina Sturdza, Jacob Lindegaard, Barbara Segedin, Umesh Mahantshetty, Bhavana Rai, Ina Jürgenliemk-Schulz, Christine Haie-Meder, Ryohei Sasaki, Richard Pötter
    PURPOSE: To assess disease response along the parametrial space according to tumor morphology in patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIB and IIIB cervical cancer at the time of image-guided adaptive brachytherapy. METHODS AND MATERIALS: Patients with FIGO stage IIB and IIIB cervical cancer registered as of November 2013 in the EMBRACE study were evaluated. Tumors were stratified according to morphologic subtype on magnetic resonance imaging (expansive and infiltrative), and the characteristics of those subtypes were analyzed. Parametrial involvement at diagnosis and at brachytherapy was evaluated, and the response to chemo-radiotherapy was classified as good, moderate, or poor. The response grade was compared between the 2 groups and analyzed with regard to tumor volumes, and dosimetric parameters. RESULTS: A total of 452 patients were evaluated, of whom 186 had expansive growth type and 266 had infiltrative morphology. Patients with infiltrative tumors had more extensive disease, as indicated by a higher rate of FIGO stage IIIB disease, as well as radiologic evidence of extension into the distal parametrial space and to the pelvic side wall on magnetic resonance imaging. Cervical necrosis was more common in the infiltrative group. Good response was more common in the expansive group (34% vs 24%; P=.02), and poor response was more common in the infiltrative group (11% and 19%; P=.02). Mean gross tumor volume at diagnosis was equal in both groups (51.7 cm(3)). The high-risk clinical target volume was larger in infiltrative tumors (37.9 cm(3) vs 33.3 cm(3), P=.005). The mean high-risk clinical target volume D90 was slightly higher in expansive tumors (92.7 Gy and 89.4 Gy, P<.001). CONCLUSION: Infiltrative tumors are more advanced at presentation and respond less favorably to chemo-radiotherapy when compared with expansive tumors that are more or less equivalent in size. The use of image-guided adaptive brachytherapy allows achieving reasonably high doses in both groups.
    Nov. 2015, International journal of radiation oncology, biology, physics, 93(4) (4), 788 - 96, English, International magazine
    [Refereed]
    Scientific journal

  • Short treatment time and excellent treatment outcome in accelerated hyperfractionated radiotherapy for T1 glottic cancer
    Yukihisa Tamaki, Yoko Hieda, Rika Yoshida, Takeshi Yoshizako, Takafumi Fuchiwaki, Noriaki Aoi, Kazumasa Sekihara, Kazuhiro Kitajima, Hideyuki Kawauchi, Hajime Kitagaki, Ryohei Sasaki, Taisuke Inomata
    Nov. 2015, NAGOYA JOURNAL OF MEDICAL SCIENCE, 77(4) (4), 585 - 594, English
    [Refereed]
    Scientific journal

  • Short treatment time and excellent treatment outcome in accelerated hyperfractionated radiotherapy for T1 glottic cancer.
    Yukihisa Tamaki, Yoko Hieda, Rika Yoshida, Takeshi Yoshizako, Takafumi Fuchiwaki, Noriaki Aoi, Kazumasa Sekihara, Kazuhiro Kitajima, Hideyuki Kawauchi, Hajime Kitagaki, Ryohei Sasaki, Taisuke Inomata
    Accelerated hyperfractionated radiotherapy was performed as treatment for patients with T1 glottic cancer, and its utility was evaluated based on treatment outcomes and adverse effects. Fifty-eight men who had undergone radiotherapy were retrospectively reviewed. Tumor classification was Tis in 4 patients, T1a in 38, and T1b in 16. Histological examination revealed squamous cell carcinoma in 55 patients. Travel time from home to hospital was 0-1 hour for 24 patients, 1-2 hours for 9, and >2 hours for 25. Laser vaporization was performed prior to radiotherapy in 38 patients, and 19 patients received concurrent chemotherapy with an agent such as S-1. Patients were irradiated twice daily using an irradiation container. Most patients received a dose of 1.5 Gy/fraction up to a total of 60 Gy. The median overall treatment time was 30 days, with a median observation period of 59.6 months. A complete response was observed in all patients. The 5-year overall survival, disease-free survival, and local control rates were 97.2%, 93.2%, and 97.8%, respectively. Although grade 3 pharyngeal mucositis was observed in 2 patients, there were no other grade 3 or higher acute adverse events. As late toxicity, grade 2 laryngeal edema and grade 1 laryngeal hemorrhage were observed in 1 patient each, but no serious events such as laryngeal necrosis or laryngeal stenosis were observed. In conclusion, this treatment method brings excellent outcome and will substantially reduce the treatment duration among patients who need to stay at nearby hotels while undergoing treatment at hospitals in rural areas.
    Nov. 2015, Nagoya journal of medical science, 77(4) (4), 585 - 94, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Kazuhiro Tanaka, Takashi Sasayama, Katsu Mizukawa, Kumi Takata, Nor Shazrina Sulaiman, Masamitsu Nishihara, Masaaki Kohta, Ryohei Sasaki, Takanori Hirose, Tomoo Itoh, Eiji Kohmura
    OBJECTIVE: The management of low-grade glioma (LGG) still remains controversial because the effectiveness of early and extensive resection is unclear, and the use of radiation therapy or chemotherapy is not well-defined. In particular, the importance of prognostic factors for survival remains a matter of discussion. The purpose of this study was to validate prognostic factors for survival in patients with LGG. MATERIALS AND METHODS: A consecutive series of 55 patients with WHO grade II LGG treated in our institute between 1983 and 2013 were retrospectively reviewed to determine the prognostic factors for survival. All data were retrospectively analyzed from the aspect of baseline characteristics, pathological findings, genetic change, surgical treatments, adjuvant therapies, and survival time. Cox multivariate analysis was performed to determine the prognostic factors for survival. RESULTS: There were 28 patients with diffuse astrocytoma (DA), 21 patients with oligodendroglioma (OG), and 6 patients with oligoastrocytoma (OA) diagnosed on initial surgery. The median overall survival was 193 months and fifteen patients (27.3%) died. A mutation in isocitrate dehydrogenase-1 (IDH1) was found in 72.9% of LGG, and this mutation was positively correlated with methylation of O6-methylguanine-DNA methyltransferase (MGMT) (p=0.02). A better prognosis was significantly associated with combined IDH1 mutation and MGMT methylation status (both positive vs both negative, HR 0.079 [95% CI 0.008-0.579], p=0.012), as well as histology (OG vs DA and OA, HR 0.158 [95% CI 0.022-0.674], p=0.011) and tumor size (<6 cm vs ≥6 cm, HR 0.120 [95% CI 0.017-0.595], p=0.008). CONCLUSIONS: Tumor histology, size and IDH-mutation status are important predictors for prolonged overall survival in patients with LGG and may provide a reliable tool for standardizing future treatment strategies.
    Nov. 2015, Clinical neurology and neurosurgery, 138, 37 - 44, English, International magazine
    [Refereed]
    Scientific journal

  • Kazuhiro Kitajima, Yuko Suenaga, Tsutomu Minamikawa, Takahide Komori, Naoki Otsuki, Ken-ichi Nibu, Ryohei Sasaki, Tomoo Itoh, Kazuro Sugimura
    Nov. 2015, SPRINGERPLUS, 4, 718, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yasuo Ejima, Yoshiro Matsuo, Ryohei Sasaki
    The management of spinal bone metastases is complex. In this review, the efficacy, methodology, and utilization of radiotherapy (RT) for spinal bone metastases are discussed. A number of randomized trials have evaluated the efficacy of 8 Gy, single-fraction RT for the palliation of painful bone metastases. However, RT for metastatic spinal cord compression has not been evaluated with respect to its optimal dose, palliative potential, or its ability to improve motor function. Two highly sophisticated RT techniques - stereotactic body RT (SBRT) and intensity-modulated RT (IMRT) - have recently been adapted for the treatment of spinal bone metastases, and both have the potential to achieve excellent control while minimizing acute and late toxicity. SBRT and IMRT are particularly well suited for the treatment of spinal bone metastases when they are localized or require re-irradiation, and may provide superior tumor control. Predicting the prognosis of patients with bone metastases and assessing spinal instability are both important when selecting the optimal RT method and deciding whether to perform surgery. The proper care of spinal bone metastases patients requires an interdisciplinary treatment approach.
    Jul. 2015, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 20(4) (4), 585 - 92, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Takashi Mizowaki, Takashi Sasayama, Shuho Semba, Ryohei Sasaki, Kensaku Yasuo, Satoshi Nakamizo, Kazuhiro Tanaka, Katsu Mizukawa, Yoshito Uchihashi, Eiji Kohmura
    Jul. 2015, BRAIN PATHOLOGY, 25(4) (4), 509 - 510, English
    [Refereed]
    Scientific journal

  • Satoshi Seno, Kazuhiro Kitajima, Go Inokuchi, Ken-ichi Nibu, Tomoo Itoh, Yasuo Ejima, Ryohei Sasaki, Koji Sugimoto, Kazuro Sugimura
    Jun. 2015, SPRINGERPLUS, 4, 250, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiroshi Hirai, Naoki Kondo, Ryohei Sasaki, Shinya Iwamuro, Kanako Masuno, Rika Ohtsuka, Hisayuki Miura, Kiyomi Sakata
    BACKGROUND: after the Great East Japan Earthquake in 2011, inactivity and the homebound status of older victims in affected areas have been a serious public health concern owing to the victims' prolonged existence as evacuees in mountainous areas. OBJECTIVE: to evaluate the association between distances to retail stores and risks of being homebound. DESIGN: secondary analysis of cross-sectional interview survey data with a geographical information analysis. SETTING: Rikuzentakata, Iwate, a municipality seriously damaged by the 2011 earthquake and tsunami. SUBJECTS: all Rikuzentakata residents aged 65 or older except for those living in temporary housing (n = 2,327). METHODS: we calculated road distances between each residential address and retail stores, hawker sites and shopping bus stops, accounting for the extra load caused by walking on slopes. The prevalence ratio of being homebound adjusted for age, source of income and morbidity by road distance was estimated using Poisson regression with a generalised estimating equation. RESULTS: those living at distances of 1,200 m or more were 1.78 (95% confidence intervals, 1.03-3.08) times more likely to be homebound (going out only every 4 or more days a week) among men and 1.85 (1.13-3.02) among women, compared with those residing in places <400 m from retail stores or shopping bus stops. The distances were reduced by new hawker and shopping bus services, but the improvements varied greatly across the districts. CONCLUSIONS: access to daily needs is essential to prevent homebound status. Post-disaster community diagnosis in terms of the built environment is important for strategic community restoration.
    May 2015, Age and ageing, 44(3) (3), 478 - 84, English, International magazine
    [Refereed]
    Scientific journal

  • 新たな放射線増感剤としての過酸化チタンナノ粒子は膵癌治療における抗腫瘍効果を増強させる(Titanium Peroxide Nanoparticles, as Novel Radiosensitizers, Enhance Antitumor Efficacy in Pancreatic Cancer Therapy)
    Nakayama Masao, Sasaki Ryohei, Ogino Chiaki, Tanaka Tsutomu, Morita Kenta, Umetsu Mitsuo, Ohara Satoshi, Sato Kazuyoshi, Numako Chiya, Takami Seiichi, Kondo Akihiko
    (一社)日本放射線影響学会, May 2015, 日本放射線影響学会大会講演要旨集, 58回, 3 - 07, English

  • 甲状腺がん 2015年の甲状腺がんの治療 甲状腺がんに対する分子標的療法(Thyroid Cancer: Treatment of Thyroid Cancer 2015 Molecular Targeted Treatment for Thyroid Cancer)
    Kiyota Naomi, Otsuki Naoki, Imamura Yoshinori, Sasaki Ryohei, Nibu Ken-ichi, Minami Hironobu
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 98 - 98, English

  • プラチナ薬剤抵抗性の頭頸部がんに関する炎症スコアの予後的な意義(Prognostic Value of the Inflammation Scores for Platinum Refractory Head and Neck Cancer)
    Imamura Yoshinori, Kiyota Naomi, Otsuki Naoki, Saito Miki, Morimoto Koichi, Komatsu Hirokazu, Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, Uezono Haruka, Ishihara Takeaki, Minamikawa Tsutomu, Sasaki Ryohei, Nibu Ken-ichi
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 136 - 136, English

  • Kazuhiro Tanaka, Takashi Sasayama, Yasuhiro Irino, Kumi Takata, Hiroaki Nagashima, Naoko Satoh, Katsusuke Kyotani, Takashi Mizowaki, Taichiro Imahori, Yasuo Ejima, Kenta Masui, Beatrice Gini, Huijun Yang, Kohkichi Hosoda, Ryohei Sasaki, Paul S. Mischel, Eiji Kohmura
    Apr. 2015, JOURNAL OF CLINICAL INVESTIGATION, 125(4) (4), 1591 - 1602, English
    [Refereed]
    Scientific journal

  • Noriaki Minami, Katsu Mizukawa, Hirofumi Iwahashi, Hiroaki Nagashima, Kazuhiro Tanaka, Takashi Sasayama, Kohkichi Hosoda, Naritoshi Mukumoto, Ryohei Sasaki, Eiji Kohmura
    Radiation-induced vasculopathy is a complication of radiation therapy. Most reports regarding post-irradiation ischemic stroke with intracranial tumors are restricted to pediatric cases. Here we report two adult cases of delayed brain infarction due to anterior and middle cerebral artery stenosis or occlusion seemingly caused by focal radiation therapy for malignant glioma. Although radiation-induced ischemic stroke in adults is relatively uncommon, it is possible that the morbidity rate of radiation-induced stroke in malignant glioma patients will increase with prolonged survival due to advances in therapy. Therefore, regular evaluation of intracranial vasculature following radiation therapy is necessary.
    Apr. 2015, No shinkei geka. Neurological surgery, 43(4) (4), 344 - 51, Japanese, Domestic magazine
    [Refereed]
    Scientific journal

  • Kazuhiro Tanaka, Takashi Sasayama, Yasuhiro Irino, Kumi Takata, Hiroaki Nagashima, Naoko Satoh, Katsusuke Kyotani, Takashi Mizowaki, Taichiro Imahori, Yasuo Ejima, Kenta Masui, Beatrice Gini, Huijun Yang, Kohkichi Hosoda, Ryohei Sasaki, Paul S Mischel, Eiji Kohmura
    The mechanistic target of rapamycin (mTOR) is hyperactivated in many types of cancer, rendering it a compelling drug target; however, the impact of mTOR inhibition on metabolic reprogramming in cancer is incompletely understood. Here, by integrating metabolic and functional studies in glioblastoma multiforme (GBM) cell lines, preclinical models, and clinical samples, we demonstrate that the compensatory upregulation of glutamine metabolism promotes resistance to mTOR kinase inhibitors. Metabolomic studies in GBM cells revealed that glutaminase (GLS) and glutamate levels are elevated following mTOR kinase inhibitor treatment. Moreover, these mTOR inhibitor-dependent metabolic alterations were confirmed in a GBM xenograft model. Expression of GLS following mTOR inhibitor treatment promoted GBM survival in an α-ketoglutarate-dependent (αKG-dependent) manner. Combined genetic and/or pharmacological inhibition of mTOR kinase and GLS resulted in massive synergistic tumor cell death and growth inhibition in tumor-bearing mice. These results highlight a critical role for compensatory glutamine metabolism in promoting mTOR inhibitor resistance and suggest that rational combination therapy has the potential to suppress resistance.
    Apr. 2015, The Journal of clinical investigation, 125(4) (4), 1591 - 602, English, International magazine
    [Refereed]
    Scientific journal

  • 局所放射線治療後に頭蓋内主幹動脈狭窄による脳梗塞を呈した成人神経膠腫の2例
    南徳明, Mizukawa Katsu, 岩橋洋文, 長嶋宏明, 田中一寛, 篠山隆司, Hosoda Kokichi, 椋本成俊, Sasaki Ryohei, Kohmura Eiji
    (株)医学書院, Apr. 2015, Neurological Surgery, 43(4) (4), 344 - 351, Japanese
    [Refereed]
    Scientific journal

  • Aya Harada, Ryohei Sasaki, Daisuke Miyawaki, Kenji Yoshida, Hideki Nishimura, Yasuo Ejima, Kazuhiro Kitajima, Miki Saito, Naoki Otsuki, Ken-Ichi Nibu
    OBJECTIVE: This retrospective study analyzed the oncological and treatment outcomes of the patients with T1-T2N0 glottic cancer, who were treated with radiotherapy as initial treatment and salvaged by conservative surgery for radiation failure. METHODS: Between May 1999 and December 2010, 115 patients with glottic laryngeal cancer were treated at Kobe University Hospital. At presentation, 54 patients had stage T1a disease, 26 had stage T1b disease and 35 had stage T2 disease. Seventy-nine patients were treated with conventional radiotherapy and 36 patients were treated with hyperfractionated radiotherapy as initial treatment. RESULTS: Median duration of follow-up was 61 months. Five-year local control rates of radiotherapy were 92% in T1a, 83% in T1b and 86% in T2. Of 12 patients who developed local recurrence, larynx was successfully preserved in 3 patients by laryngomicrosurgery, 7 patients by vertical partial laryngectomy and one patient by subtotal laryngectomy. Ultimate 5-year laryngeal preservation rate and local control rate of all cases were 99 and 100%, respectively. CONCLUSIONS: Present results suggest that initial treatment with radiotherapy salvaged by organ preservation surgery is an effective strategy for laryngeal preservation in the treatment of T1-T2N0 glottic laryngeal cancer.
    Mar. 2015, Japanese journal of clinical oncology, 45(3) (3), 248 - 55, English, International magazine
    [Refereed]
    Scientific journal

  • Osamu Fujii, Yusuke Demizu, Naoki Hashimoto, Masaru Takagi, Kazuki Terashima, Masayuki Mima, Dongcun Jin, Fumiko Nagano, Kuniaki Katsui, Tomoaki Okimoto, Hiromitsu Iwata, Yasue Niwa, Tomohiro Yamashita, Takashi Akagi, Takashi Daimon, Ryohei Sasaki, Yoshio Hishikawa, Mitsuyuki Abe, Masao Murakami, Nobukazu Fuwa
    BACKGROUND: The purpose of the present study was to present the treatment outcomes of particle therapy for indeterminate pulmonary nodules (IPNs) diagnosed as stage I non-small cell lung cancer, including a comparative analysis involving pathologically proven lung cancer (PPLC). MATERIAL AND METHODS: A total of 54 patients (57 lesions) who underwent particle therapy for IPNs were enrolled in this study. Median patient age was 76 (range 52-87) years. T-classification was: T1a, 30; T1b, 16; and T2a, 11. Particle therapy using protons or carbon ions was delivered at total doses of 52.8-80 Gy equivalent in 4-26 fractions. The PPLC cohort included 111 patients. RESULTS: The median follow-up time was 41 (range 7-90) months. For all IPN patients, the three-year overall survival, progression-free survival, local control and distant progression-free survival rates were 90%, 72%, 94% and 79%, respectively. Grade 2 toxicities were radiation pneumonitis (19%), dermatitis (9%), rib fracture (2%), chest wall pain (2%) and neuropathy (2%). No ≥grade 3 toxicities were observed. In univariate analysis, the IPN group showed significantly better survival relative to the PPLC group. However, after adjustment for baseline imbalances between these two groups in multivariate analysis, pathological confirmation did not correlate with survival. CONCLUSIONS: Particle therapy for IPNs provided favorable outcomes with minimal toxicities, which may be comparable to those for PPLC patients. Further studies are needed to clarify the optimal management of IPN patients.
    Mar. 2015, Acta oncologica (Stockholm, Sweden), 54(3) (3), 315 - 21, English, International magazine
    [Refereed]
    Scientific journal

  • Takanobu Shimada, Naomi Kiyota, Yosinori Imamura, Koichi Morimoto, Miki Saito, Hideki Nishimura, Naoki Otsuki, Ryohei Sasaki, Ken-Ichi Nibu
    Japan Society for Head and Neck Cancer, Jan. 2015, Japanese Journal of Head and Neck Cancer, 40(4) (4), 490 - 496, Japanese
    [Refereed]
    Scientific journal

  • Masaru Takagi, Yusuke Demizu, Naoki Hashimoto, Masayuki Mima, Kazuki Terashima, Osamu Fujii, Dongcun Jin, Yasue Niwa, Koichi Morimoto, Takashi Akagi, Takashi Daimon, Ryohei Sasaki, Yoshio Hishikawa, Mitsuyuki Abe, Masao Murakami, Nobukazu Fuwa
    BACKGROUND AND PURPOSE: The aim of this study was to retrospectively analyse the outcomes of cases of adenoid cystic carcinomas (ACCs) of the head and neck that were treated at a single institution with particle therapy consisting of either protons or carbon ions. METHODS AND MATERIALS: Between February 2002 and March 2012, 80 patients were treated with proton therapy (PT) or carbon ion therapy (CIT) alone. PT and CIT were employed in 40 (50%) patients each, and more than half of the patients received 65.0 GyE in 26 fractions (n=47, 59%). RESULTS: The median duration of follow-up was 38 months (range, 6-115 months). For all patients, the 5-year for overall survival (OS) rate, progression-free survival (PFS) rate, and local control (LC) rate were 63%, 39%, and 75%, respectively. No significant differences between PT and CIT were observed. The 5-year LC rates for T4 and inoperable cases were 66% and 68%, respectively. Twenty-one patients (26%) experienced grade 3 or greater late toxicities, including three patients who developed grade 5 bleeding from nasopharyngeal ulcers. CONCLUSIONS: Particle radiotherapy for ACC achieves favourable LC, and its efficacy in inoperable or T4 cases is promising. There were no significant differences between PT and CIT in terms of OS, PFS and LC.
    Dec. 2014, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 113(3) (3), 364 - 70, English, International magazine
    [Refereed]
    Scientific journal

  • Hiroaki Akasaka, Ryohei Sasaki, Daisuke Miyawaki, Naritoshi Mukumoto, Nor Shazrina Binti Sulaiman, Masaaki Nagata, Shigeru Yamada, Masao Murakami, Yusuke Demizu, Takumi Fukumoto
    Dec. 2014, International journal of radiation oncology, biology, physics, 90(5) (5), 1177 - 85, English, International magazine
    [Refereed]
    Scientific journal

  • Fujii O, Demizu Y, Hashimoto N, Takagi M, Terashima K, Mima M, Jin D, Nagano F, Katsui K, Okimoto T, Iwata H, Niwa Y, Yamashita T, Akagi T, Daimon T, Sasaki Ryohei, Hishikawa Y, Abe M, Murakami M, Fuwa N
    Nov. 2014, Acta Oncol, 10(1) (1), 1 - 7, English
    [Refereed]
    Scientific journal

  • Nor Shazrina Sulaiman, Osamu Fujii, Yusuke Demizu, Kazuki Terashima, Yasue Niwa, Takashi Akagi, Takashi Daimon, Masao Murakami, Ryohei Sasaki, Nobukazu Fuwa
    BACKGROUND: A study was undertaken to analyze the efficacy and feasibility of particle beam radiation therapy (PBRT) using carbon ions and protons for the treatment of patients with oligometastatic lung tumors. METHODS: A total of 47 patients with 59 lesions who underwent PBRT for oligometastatic lung tumors between 2003 and 2011 were included in this study. Patient median age was 66 (range, 39-84) years. The primary tumor site was the colorectum in 11 patients (23.4%), lung in 10 patients (21.3%) and a variety of other sites in 26 patients (55.3%). Thirty-one patients (66%) received chemotherapy prior to PBRT. Thirty-three lesions were treated with 320-MeV carbon ions and 26 were treated with 150- or 210-Mev protons in 1-4 portals. A median total dose of 60 (range, 52.8-70.2) GyE was delivered at the isocenter in 8 (range, 4-26) fractions. RESULTS: The median follow-up time was 17 months. The local control, overall survival and progression-free survival rates at 2 years were 79%, 54 and 27% respectively. PBRT-related toxicities were observed; six patients (13%) had grade 2 toxicity (including grade 2 radiation pneumonitis in 2) and six patients (13%) had grade 3 toxicity. Univariate analysis indicated that patients treated with a biologically equivalent dose of 10 (BED10) <110 GyE10, had a significantly higher local recurrence rate. Local control rates were relatively lower in the subsets of patients with the colorectum as the primary tumor site. No local progression was observed in metastases from colorectal cancer irradiated with a BED10 ≥ 110 GyE10. There was no difference in treatment results between proton and carbon ion therapy. CONCLUSIONS: PRBT is well tolerated and effective in the treatment of oligometastatic lung tumors. To further improve local control, high-dose PBRT with a BED10 ≥ 110 GyE10 may be promising. Further investigation of PBRT for lung oligometastases is warranted.
    Aug. 2014, Radiation oncology (London, England), 9, 183 - 183, English, International magazine
    [Refereed]
    Scientific journal

  • Yasuo Onishi, Toshihiro Akisue, Teruya Kawamoto, Takeshi Ueha, Hitomi Hara, Mitsunori Toda, Risa Harada, Masaya Minoda, Masayuki Morishita, Ryohei Sasaki, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka
    Aug. 2014, International journal of oncology, 45(2) (2), 732 - 8, English, International magazine
    [Refereed]
    Scientific journal

  • Masao Nakayama, Kenji Yoshida, Hideki Nishimura, Daisuke Miyawaki, Kazuyuki Uehara, Yoshiaki Okamoto, Takanobu Okayama, Ryohei Sasaki
    The present study aimed to investigate the effect of heterogeneity correction (HC) on dosimetric parameters in 3-dimensional conformal radiotherapy planning for patients with thoracic esophageal cancer. We retrospectively analyzed 20 patients. Two treatment plans were generated for each patient using a superposition algorithm on the Xio radiotherapy planning system. The first plan was calculated without HC. The second was a new plan calculated with HC, using identical beam geometries and maintaining the same number of monitor units as the first. With regard to the planning target volume (PTV), the overall mean differences in the prescription dose, maximum dose, mean dose, and dose that covers 95% of the PTV between the first and second plans were 1.10Gy (1.8%), 1.35Gy (2.2%), 1.10Gy (1.9%), and 0.56Gy (1.0%), respectively. With regard to parameters related to the organs at risk (OARs), the mean differences in the absolute percentages of lung volume receiving greater than 5, 10, 20, and 30Gy (lung V5, V10, V20, and V30) between the first and second plans were 7.1%, 2.7%, 0.4%, and 0.5%, respectively. These results suggest that HC might have a more pronounced effect on the percentages of lung volume receiving lower doses (e.g., V5 and V10) than on the dosimetric parameters related to the PTV and other OARs.
    2014, Medical dosimetry : official journal of the American Association of Medical Dosimetrists, 39(1) (1), 31 - 3, English, International magazine
    [Refereed]
    Scientific journal

  • Masayuki Mima, Y. Demizu, D. Jin, N. Hashimoto, M. Takagi, K. Terashima, O. Fujii, Y. Niwa, T. Akagi, T. Daimon, Y. Hishikawa, M. Abe, M. Murakami, R. Sasaki, N. Fuwa
    Jan. 2014, British Journal of Radiology, 87(1033) (1033), 20130512, English
    [Refereed]
    Scientific journal

  • Takeaki Ishihara, Eisaku Yoden, Kei Konishi, Naomi Nagase, Kenji Yoshida, Junichi Kurebayashi, Hiroshi Sonoo, Nobutaka Murashima, Ryohei Sasaki, Junichi Hiratsuka
    Jan. 2014, Breast cancer (Tokyo, Japan), 21(1) (1), 40 - 6, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Kazuhiro Kitajima, Yuko Suenaga, Tomonori Kanda, Daisuke Miyawaki, Kenji Yoshida, Yasuo Ejima, Ryohei Sasaki, Hirokazu Komatsu, Miki Saito, Naoki Otsuki, Ken-Ichi Nibu, Naomi Kiyota, Tsutomu Minamikawa, Kazuro Sugimura
    2014, PloS one, 9(5) (5), e96999, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • [Current status and future of the radiotherapy for pancreas cancer].
    Ryohei Sasaki, Daisuke Miyawaki
    Dec. 2013, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 110(12) (12), 2073 - 80, Japanese, Domestic magazine
    [Refereed]
    Scientific journal

  • [The effect of strontium-89 therapy in a patient with cholangiocellular carcinoma].
    Eiro Sakai, Yumiko Masuda, Yoshiharu Sato, Shoji Matsui, Kyosuke Ota, Ryohei Sasaki, Miyawaki Daisuke
    A 77-year-old man was diagnosed as having cholangiocellular carcinoma. The patient underwent partial right hepatectomy in June 2008, and multiple bone metastases occurred approximately 9 months after surgery. He refused salvage chemotherapy and radiation therapy. Although he had been treated with opiate analgesics, he was unable to sit up owing to severe pain in the left ilium. He was hospitalized because of buttock pain and left leg numbness. Even a combination of fentanyl patch, gabapentin, and subarachnoid block was ineffective in controlling pain. Strontium-89 (89Sr) therapy was successful in eliminating the intractable pain, and there were no serious side effects during therapy. The patient was discharged from the hospital, and he received palliative care at home for a short period.
    Nov. 2013, Gan to kagaku ryoho. Cancer & chemotherapy, 40(12) (12), 1856 - 8, Japanese, Domestic magazine
    [Refereed]
    Scientific journal

  • Tomonori Kanda, Kazuhiro Kitajima, Yuko Suenaga, Jyunya Konishi, Ryohei Sasaki, Koichi Morimoto, Miki Saito, Naoki Otsuki, Ken-Ichi Nibu, Kazuro Sugimura
    Nov. 2013, European Journal of Radiology, 82(11) (11), 2005 - 2010, English
    [Refereed]
    Scientific journal

  • Haruka Uezono, Kayoko Tsujino, Keno Moriki, Fumiko Nagano, Yosuke Ota, Ryohei Sasaki, Toshinori Soejima
    The purpose of this study is to determine the incidence, clinical characteristics and risk factors of postradiation pelvic insufficiency fracture (PIF) in women with uterine cervical cancer. We reviewed the medical records of 126 patients who received definitive radiotherapy (RT) for uterine cervical cancer between 2003 and 2009 at our institution. Among them, 99 patients who underwent at least one computed tomography (CT) or magnetic resonance imaging of the pelvis during their follow-up at more than 6 months were included in this analysis. The relationship between the incidence of PIF and several patient- and treatment-related factors was analyzed. The median follow-up period was 21 months. Of the 126 patients, 33 (with a total of 50 lesions) were diagnosed with PIF. The 2-year cumulative incidence was 32%. Univariate analysis showed that age ≥70 years (P= 0.0010), postmenopausal state (P = 0.0013), and lower CT density of bone and bone marrow (P= 0.020) significantly related to PIF. In a multivariate analysis, of the 59 patients whose CT densities were evaluable, lower CT density was the only significant factor associated with PIF (P = 0.0026). In conclusion, postradiation PIFs were detected in a considerable number of patients after definitive RT for cervical cancer. Predisposing factors were older age, postmenopausal state, and decreased density of bone and bone marrow on CT.
    Nov. 2013, Journal of radiation research, 54(6) (6), 1102 - 9, English, International magazine
    [Refereed]
    Scientific journal

  • Osamu Fujii, Yusuke Demizu, Naoki Hashimoto, Masayuki Araya, Masaru Takagi, Kazuki Terashima, Masayuki Mima, Hiromitsu Iwata, Yasue Niwa, Dongcun Jin, Takashi Daimon, Ryohei Sasaki, Yoshio Hishikawa, Mitsuyuki Abe, Masao Murakami, Nobukazu Fuwa
    BACKGROUND AND PURPOSE: This retrospective study aimed to compare the clinical outcomes and late toxicities of proton therapy (PT) with those of carbon ion therapy (CIT) for stage I non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: A total of 111 patients who underwent particle therapy for stage I NSCLC between April 2003 and December 2009 were enrolled in this study. PT (n=70) and CIT (n=41) were delivered to total doses of 52.8-80 GyE in 4-26 fractions and 52.8-70.2 GyE in 4-26 fractions, respectively. The median follow-up time was 41 months. RESULTS: Differences in outcome between the PT and CIT groups regarding 3-year overall survival (72% and 76%, respectively), progression-free survival (44% and 53%, respectively), and local control (81% and 78%, respectively) were not statistically significant. In multivariate analysis, the type of treatment beam did not correlate with overall survival. The severity of late toxicities was comparable between the two groups. CONCLUSIONS: Clinical results in the PT group were comparable to those in the CIT group. However, this study was a retrospective analysis of a highly heterogeneous population. Consequently, more homogeneous prospective data, large multicentric databases and, ideally, randomized trials are warranted.
    Oct. 2013, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 109(1) (1), 32 - 7, English, International magazine
    [Refereed]
    Scientific journal

  • ナノ粒子とX線照射を併用した深部ガンの非侵襲的治療法の開発
    田野 亜都里, 森田 健太, 荻野 千秋, 佐藤 和好, 沼子 千弥, 中山 雅央, Sasaki Ryohei, 近藤 昭彦
    日本生物工学会, Aug. 2013, 日本生物工学会大会講演要旨集平成25年度, 65, 244 - 244, Japanese
    Research society

  • Hiromitsu Iwata, Yusuke Demizu, Osamu Fujii, Kazuki Terashima, Masayuki Mima, Yasue Niwa, Naoki Hashimoto, Takashi Akagi, Ryohei Sasaki, Yoshio Hishikawa, Mitsuyuki Abe, Yuta Shibamoto, Masao Murakami, Nobukazu Fuwa
    INTRODUCTION: : Although many reports have shown the safety and efficacy of stereotactic body radiotherapy (SBRT) for T1N0M0 non-small-cell lung cancer (NSCLC), it is rather difficult to treat T2N0M0 NSCLC, especially T2b (>5 cm) tumor, with SBRT. Our hypothesis was that particle therapy might be superior to SBRT in T2 patients. We evaluated the clinical outcome of particle therapy for T2a/bN0M0 NSCLC staged according to the 7th edition of the International Union Against Cancer (UICC) tumor, node, metastasis classification. METHODS: : From April 2003 to December 2009, 70 histologically confirmed patients were treated with proton (n = 43) or carbon-ion (n = 27) therapy according to institutional protocols. Forty-seven patients had a T2a tumor and 23 had a T2b tumor. The total dose and fraction (fr) number were 60 (Gray equivalent) GyE/10 fr in 20 patients, 52.8 GyE/4 fr in 16, 66 GyE/10 fr in 16, 80 GyE/20 fr in 14, and other in four patients, respectively. Toxicities were scored according to the Common Terminology Criteria for Adverse Events, Version 4.0. RESULTS: : The median follow-up period for living patients was 51 months (range, 24-103). For all 70 patients, the 4-year overall survival, local control, and progression-free survival rates were 58% (T2a, 53%; T2b, 67%), 75% (T2a, 70%; T2b, 84%), and 46% (T2a, 43%; T2b, 52%), respectively, with no significant differences between the two groups. The 4-year regional recurrence rate was 17%. Grade 3 pulmonary toxicity was observed in only two patients. CONCLUSION: : Particle therapy is well tolerated and effective for T2a/bN0M0 NSCLC. To further improve treatment outcome, adjuvant chemotherapy seems a reasonable option, whenever possible.
    Jun. 2013, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 8(6) (6), 726 - 35, English, International magazine
    [Refereed]
    Scientific journal

  • Tetsuro Kawamura, Naoki Murakami, Yoshiaki Okamura, Hideki Nishimura, Daisuke Miyawaki, Kunihiko Kimura, Mamoru Hase, Ryohei Sasaki
    Image-guided radiation therapy (IGRT) is increasingly being used in modern radiation therapy, and it is now possible to verify a patient's position using kilo-voltage cone-beam computed tomography (kV-CBCT). However, if kV-CBCT is used frequently, the dose absorbed by the body cannot be disregarded. A number of studies have been made on the absorbed dose of kV-CBCT, in which absorbed dose measurements were made using a computed tomography dose index (CTDI) or a thermoluminescent dosimeter (TLD). Other methods include comparison of the absorbed dose between a kV-CBCT and other modalities. These techniques are now in common use. However, dose distribution within the patient varies with the patient's size, posture and the part of the body to which radiation therapy is applied. The chief purpose of this study was to evaluate the dose distribution of kV-CBCT by employing a radiotherapy planning system (RTPS); a secondary aim was to examine the influence of a dose of kV-CBCT radiation when used to treat prostate cancer. The beam data of an on-board imager (OBI) was registered in the RTPS, after which modeling was performed. The radiation dosimetry was arranged by the dosimeter in an elliptical phantom. Rotational radiation treatment was used to obtain the dose distribution of the kV-CBCT within the patient, and the patient dose was evaluated based on the simulation of the dose distribution. In radiation therapy for prostate cancer, if kV-CBCT was applied daily, the dose increment within the planning target volume (PTV) and the organ in question was about 1 Gy.
    May 2013, Nihon Hoshasen Gijutsu Gakkai zasshi, 69(5) (5), 491 - 9, Japanese, Domestic magazine
    [Refereed]
    Scientific journal

  • 当院における唾液腺導管癌15例の臨床病理学的特徴
    今村 善宣, Kiyota Naomi, 大月 直樹, 島田 貴信, 山下 大介, Sasaki Ryohei, 丹生 健一
    May 2013, 頭頸部癌, 39(2号) (2号), 233, Japanese
    Research society

  • 再発・転移頭頸部がんに対するドセタキセル・シスプラチン併用(DC)療法
    島田 貴信, Kiyota Naomi, 今村 善宣, Morimoto Koichi, 斎藤 幹, 西村 英輝, Sasaki Ryohei, 大月 直樹, 丹生 健一
    May 2013, 頭頸部癌, 39(2号) (2号), 194, Japanese
    Research society

  • 顎下腺脱分化型腺様嚢胞癌の1例
    入谷 啓介, 福田 有里子, 大月 直樹, 丹生 健一, ノル・シャズリナ, 吉田 賢史, Sasaki Ryohei
    May 2013, 頭頸部癌, 39(2号) (2号), 206, Japanese
    Research society

  • Hiroaki Akasaka, Ryohei Sasaki, Kenji Yoshida, Izumi Takayama, Toyofumi Yamaguchi, Hiromi Yoshida, Yoshiyuki Mizushina
    Mar. 2013, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1830(3) (3), 2517 - 2525, English
    [Refereed]
    Scientific journal

  • 神戸大学におけるI-125密封小線源永久挿入療法の治療成績
    村蒔 基次, 古川 順也, 田中 一志, 三宅 秀明, 吉田 賢史, Sasaki Ryohei, 杉村 和朗, 藤澤 正人
    Mar. 2013, 日本泌尿器科学会雑誌, 104(2号) (2号), 350, Japanese
    Research society

  • 鼻腔原発NK/T細胞リンパ腫に対する放射線治療経験
    原田 文, Miyawaki Daisuke, 西村 英輝, 吉田 賢史, Yakushijin Kimikazu, 松岡 広, 土井 清司, 大月 直樹, 丹生 健一, Sasaki Ryohei
    (公社)日本医学放射線学会, Feb. 2013, 日本医学放射線学会学術集会抄録集, 72回(72回) (72回), S402 - S402, Japanese
    [Refereed]
    Research society

  • 頭頸部腺様嚢胞癌に対する放射線治療の経験
    片山 直人, 吉田 賢史, 西村 英輝, Miyawaki Daisuke, 橋本 直樹, 村岡 修, Sasaki Ryohei, 斎藤 幹, 大月 直樹, 丹生 健一
    (公社)日本医学放射線学会, Feb. 2013, Japanese Journal of Radiology, 31(Suppl.I) (Suppl.I), 47 - 47, Japanese
    [Refereed]
    Research society

  • 成人型頭蓋外血管腫・血管奇形に対する放射線治療の経験
    松尾 圭朗, 吉田 賢史, 西村 英輝, Miyawaki Daisuke, ノル・シャズリナ, 江島 泰生, 岡本 欣晃, 小島 芳夫, 副島 俊典, Sasaki Ryohei
    (公社)日本医学放射線学会, Feb. 2013, 日本医学放射線学会学術集会抄録集, 72回(72回) (72回), S379 - S380, Japanese
    [Refereed]
    Research society

  • 局所進行食道癌に対する化学放射線治療
    小田 麻生, 西村 英輝, 吉田 賢史, Miyawaki Daisuke, 村岡 修, 原田 文, ノル・シャズリナ・ビンティ・スライマン, Sasaki Ryohei, 奥野 達哉, Kiyota Naomi
    (公社)日本医学放射線学会, Feb. 2013, Japanese Journal of Radiology, 31(Suppl.I) (Suppl.I), 51 - 51, Japanese
    [Refereed]
    Research society

  • 間質性肺炎合併I期非小細胞肺癌に対する粒子線治療成績
    岩田 宏満, 芝本 雄太, 出水 祐介, 藤井 收, 寺島 千貴, 美馬 正幸, 丹羽 康江, 橋本 直樹, 村上 昌雄, Sasaki Ryohei
    Feb. 2013, Japanese Journal of Radiology, 31(Suppl.I) (Suppl.I), 41, Japanese
    Research society

  • SASAKI Ryohei, MIYAWAKI Daisuke
    放射線療法は，切除可能膵がんに対しては術後の補助療法として有用との報告があり，切除不能進行膵がんに対して化学放射線療法の有用性が広く研究されている．5-FU併用の化学放射線療法が標準とされるが，近年，膵がんにはゲムシタビン塩酸塩やS-1が奏効すると報告されている背景からも，将来的にはゲムシタビン塩酸塩やS-1併用の化学放射線療法が主体となる可能性が高い．放射線治療計画では胃，十二指腸などの周囲臓器や腎臓，脊髄の線量を十分に検討することが必要であり，より線量集中性のよいIMRTなどの高精度放射線治療を活用し，化学療法の利点をうまく融合した，より治療効果比の高い併用療法が開発されることが期待される．
    The Japanese Society of Gastroenterology, 2013, Nippon Shokakibyo Gakkai Zasshi, 110(12) (12), 2073 - 2080, Japanese

  • Zhenquan Tan, Kazuyoshi Sato, Seiichi Takami, Chiya Numako, Mitsuo Umetsu, Kohei Soga, Masao Nakayama, Ryohei Sasaki, Tsutomu Tanaka, Chiaki Ogino, Akihiko Kondo, Kazuhiro Yamamoto, Takeshi Hashishin, Satoshi Ohara
    2013, RSC ADVANCES, 3(42) (42), 19268 - 19271, English
    [Refereed]
    Scientific journal

  • Koichiro Yonezawa, Koichi Morimoto, Daisuke Yamashita, Hitoshi Tanimoto, Miki Saito, Naoki Otsuki, Naomi Kiyota, Ryohei Sasaki, Ken-ichi Nibu
    Japan Society for Head and Neck Cancer, 2013, Japanese Journal of Head and Neck Cancer, 39(1) (1), 72 - 76, Japanese
    [Refereed]
    Scientific journal

  • 放射線治療医が求める呼吸器核医学画像
    Sasaki Ryohei
    Nov. 2012, 核医学, 49(4号) (4号), 407, Japanese
    [Invited]
    Research society

  • Hideki Nishimura, Ryohei Sasaki, Kenji Yoshida, Daisuke Miyawaki, Yoshiaki Okamoto, Naomi Kiyota, Miki Saito, Naoki Otsuki, Ken-ichi Nibu
    Hypopharyngeal squamous cell carcinoma (HPSCC) is usually diagnosed at an advanced stage, and early-stage HPSCC is relatively rare. Because of the rarity of early-stage HPSCC, few reports have been published on the efficacy of radiotherapy (RT) in its treatment. We retrospectively reviewed the clinical records of 45 consecutive patients with Stage I and II HPSCC from May 1991 to June 2010. Patient characteristics were as follows: median age, 66 years (range, 44-90 years); male/female, 39/6; and T1/T2, 27/18. The irradiation dose ranged from 60 to 72 Gy (median: 70 Gy). Of the 45 patients, 21 underwent concurrent chemotherapy. With a median follow-up period of 62 months, the 5-year overall survival rate was 81%. Local failure occurred in 5 patients, and the 5-year local control rate was 83%. All local recurrences were successfully salvaged by surgery. The 5-year functional larynx preservation rate was 92%. Acute toxicity was manageable. Grade 3 laryngeal edema and Grade 3 hypothyroidism occurred in 1 patient each. No other late adverse events of Grade 3 or greater were observed. Based on these results, RT seemed to be an effective treatment modality for early HPSCC, with favorable organ preservation and acceptable adverse events. Early detection and accurate management of local recurrence and second malignancy was deemed to be critical.
    Nov. 2012, Journal of radiation research, 53(6) (6), 892 - 9, English, International magazine
    [Refereed]
    Scientific journal

  • Sasaki Ryohei
    Nov. 2012, Biochim Biophys Acta, 1830(3) (3), 2517 - 2525, English
    [Refereed]
    Scientific journal

  • Yukihisa Tamaki, Ryohei Sasaki, Yasuo Ejima, Masakazu Ogura, Yoshiharu Negoro, Toshifumi Nakajima, Masao Murakami, Yasushi Kaji, Kazuro Sugimura
    We investigated whether intraoperative radiotherapy (IORT) during curative surgery for esophageal carcinoma is useful or not. The cases of 117 patients diagnosed with thoracoabdominal esophageal carcinoma who underwent curative surgery between 1986 and 2007 were reviewed: 72 patients received IORT (IORT group) and 45 did not (non-IORT group). Upper abdominal lymphadenectomy was performed in 115 patients (98.5%). Seventy patients (59.8%) received chemotherapy and 80 patients (68.4%) received external radiotherapy. IORT encompassed the upper abdominal lymph node area. A single-fraction dose of 20-30 Gy was delivered using high-energy electrons. Median follow-up duration for patients was 7.4 years. The 5-year overall survival rate did not significantly differ between the IORT and non-IORT groups. However, the 5-year abdominal control rate was significantly higher in the IORT group (89.2%) than in the non-IORT group (72.9%; P = 0.022). We next focused on a patient subgroup with a primary lesion in the lower thoracic or abdominal esophagus or measuring >6 cm in length since this subgroup is probably at high risk of upper abdominal lymph node metastasis. Of the 117 patients, 75 belonged to this subgroup, and among them 45 received IORT. Both univariate and multivariate analysis revealed the survival rate was significantly higher in patients who received IORT than in those who did not (P = 0.033 univariate; 0.026 multivariate). There were no obvious perioperative complications solely attributed to IORT. IORT for esophageal carcinoma will likely be effective for patients with a primary lesion in the lower thoracic or abdominal esophagus, or with a long lesion.
    Nov. 2012, Journal of radiation research, 53(6) (6), 882 - 91, English, International magazine
    [Refereed]
    Scientific journal

  • 小型肺結節影の診断と治療 画像診断、病理、予後 すりガラス影(GGO)を呈する肺結節95症例に対する定位放射線治療成績
    Sasaki Ryohei, Miyawaki Daisuke
    Oct. 2012, 肺癌, 52(5号) (5号), 523, Japanese
    [Refereed]
    Symposium

  • Kazuyuki Uehara, Takashi Sasayama, Daisuke Miyawaki, Hideki Nishimura, Kenji Yoshida, Yoshiaki Okamoto, Naritoshi Mukumoto, Hiroaki Akasaka, Masamitsu Nishihara, Osamu Fujii, Toshinori Soejima, Kazuro Sugimura, Eiji Kohmura, Ryohei Sasaki
    Jun. 2012, RADIATION ONCOLOGY, 7, 104, English
    [Refereed]
    Scientific journal

  • Kazuki Terashima, Yusuke Demizu, Naoki Hashimoto, Dongcun Jin, Masayuki Mima, Osamu Fujii, Yasue Niwa, Kento Takatori, Naoto Kitajima, Sachiyo Sirakawa, Ku Yonson, Yoshio Hishikawa, Mitsuyuki Abe, Ryohei Sasaki, Kazuro Sugimura, Masao Murakami
    PURPOSE: We conducted the study to assess the feasibility and efficacy of gemcitabine-concurrent proton radiotherapy (GPT) for locally advanced pancreatic cancer (LAPC). MATERIALS AND METHODS: Of all 50 patients who participated in the study, 5 patients with gastrointestinal (GI)-adjacent LAPC were enrolled in P-1 (50 Gy equivalent [GyE] in 25 fractions) and 5 patients with non-GI-adjacent LAPC in P-2 (70.2 GyE in 26 fractions), and 40 patients with LAPC regardless of GI-adjacency in P-3 (67.5 GyE in 25 fractions using the field-within-a-field technique). In every protocol, gemcitabine (800 mg/m(2)/week for 3 weeks) was administered concurrently. Every patient received adjuvant chemotherapy including gemcitabine after GPT within the tolerable limit. RESULTS: The median follow-up period was 12.5 months. The scheduled GPT was feasible for all except 6 patients (12%) due to acute hematologic or GI toxicities. Grade 3 or greater late gastric ulcer and hemorrhage were seen in 5 patients (10%) in P-2 and P-3. The one-year freedom from local-progression, progression-free, and overall survival rates were 81.7%, 64.3%, and 76.8%, respectively. CONCLUSION: GPT was feasible and showed high efficacy. Although the number of patients and the follow-up periods are insufficient, the clinical results seem very encouraging.
    Apr. 2012, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 103(1) (1), 25 - 31, English, International magazine
    [Refereed]
    Scientific journal

  • Naoki Hashimoto, Ryohei Sasaki, Hideki Nishimura, Kenji Yoshida, Daisuke Miyawaki, Masao Nakayama, Kazuyuki Uehara, Yoshiaki Okamoto, Yasuo Ejima, Atsushi Azumi, Toshimitsu Matsui, Kazuro Sugimura
    PURPOSE: To evaluate the long-term treatment outcome and disease behavior of primary ocular adnexal MALT (mucosa-associated lymphoid tissue) lymphoma (POAML) after treatment with radiotherapy. METHODS AND MATERIALS: Seventy-eight patients (42 male, 36 female) diagnosed with stage I POAML between 1991 and 2010 at Kobe University Hospital were included. The median age was 60 years (range, 22-85 years). The median radiation dose administered was 30.6 Gy. Rituximab-based targeted therapy and/or chemotherapy was performed in 20 patients (25.6%). Local control (LC), recurrence-free survival (RFS), and overall survival (OS) rates were calculated using the Kaplan-Meier method. RESULTS: The median follow-up duration was 66 months. Major tumor sites were conjunctiva in 37 patients (47.4%), orbita in 29 (37.2%), and lacrimal glands in 12 (15.4%). The 5- and 10-year OS rates were 98.1% and 95.3%, respectively. The 5- and 10-year LC rates were both 100%, and the 5- and 10-year RFS rates were 88.5% and 75.9%, respectively. Patients treated with a combination of radiotherapy and targeted therapy and/or chemotherapy had a trend for a better RFS compared with those treated with radiotherapy alone (p = 0.114). None developed greater than Grade 2 acute morbidity. There were 14 patients who experienced Grade 2 morbidities (cataract: 14; retinal disorders: 7; dry eye: 3), 23 patients who had Grade 3 morbidities (cataract: 23; dry eye: 1), and 1 patient who had Grade 4 glaucoma. CONCLUSIONS: Radiotherapy for POAML was shown to be highly effective and safe for LC and OS on the basis of long-term observation. The absence of systemic relapse in patients with combined-modality treatment suggests that lower doses of radiation combined with targeted therapy may be worth further study.
    Mar. 2012, International journal of radiation oncology, biology, physics, 82(4) (4), 1509 - 14, English, International magazine
    [Refereed]
    Scientific journal

  • 前立腺癌患者における小線源療法後の下部尿路症状に対するシロドシンの予防効果を検討する無作為化比較試験
    Muramaki Mototsugu, Furukawa Jyunya, Tanaka Kazushi, Miyake Hideaki, Yoshida Kenji, Sasaki Ryohei, Sugimura Kazuro, Fujisawa Masato
    Mar. 2012, 日本泌尿器科学会雑誌, 103(2号) (2号), 459, Japanese
    [Refereed]
    Research society

  • Ryohei Sasaki, Koichi Yasuda, Eisuke Abe, Nobue Uchida, Mitsuhiko Kawashima, Takashi Uno, Masayuki Fujiwara, Yoshiyuki Shioyama, Yoshikazu Kagami, Yuta Shibamoto, Kensei Nakata, Yoshie Takada, Tetsuya Kawabe, Kazuyuki Uehara, Kenichi Nibu, Syogo Yamada
    PURPOSE: The purpose of this study was to elucidate the efficacy and optimal method of radiotherapy in the management of solitary extramedullary plasmacytoma occurring in the head and neck regions (EMPHN). METHODS AND MATERIALS: Sixty-seven patients (43 male and 24 female) diagnosed with EMPHN between 1983 and 2008 at 23 Japanese institutions were reviewed. The median patient age was 64 years (range, 12-83). The median dose administered was 50 Gy (range, 30-64 Gy). Survival data were calculated by the Kaplan-Meier method. RESULTS: The median follow-up duration was 63 months. Major tumor sites were nasal or paranasal cavities in 36 (54%) patients, oropharynx or nasopharynx in 16 (23%) patients, orbita in 6 (9%) patients, and larynx in 3 (5%) patients. The 5- and 10-year local control rates were 95% and 87%, whereas the 5- and 10-year disease-free survival rates were 56% and 54%, respectively. There were 5 (7.5%), 12 (18%), and 8 (12%) patients who experienced local failure, distant metastasis, and progression to multiple myeloma, respectively. In total, 18 patients died, including 10 (15%) patients who died due to complications from EMPHN. The 5- and 10-year overall survival (OS) rates were 73% and 56%, respectively. Radiotherapy combined with surgery was identified as the lone significant prognostic factor for OS (p = 0.04), whereas age, gender, radiation dose, tumor size, and chemotherapy were not predictive. No patient experienced any severe acute morbidity. CONCLUSIONS: Radiotherapy was quite effective and safe for patients with EMPHN. Radiotherapy combined with surgery produced a better outcome according to survival rates. These findings require confirmation by further studies with larger numbers of patients with EMPHN.
    Feb. 2012, International journal of radiation oncology, biology, physics, 82(2) (2), 626 - 34, English, International magazine
    [Refereed]
    Scientific journal

  • 脳幹部Gliomaに対する放射線治療の経験
    Yoshida Kenji, Miyawaki Daisuke, Hayakawa Akira, Sasayama Takashi, Sasaki Ryohei
    (公社)日本医学放射線学会, Feb. 2012, 日本医学放射線学会学術集会抄録集, 71回(71回) (71回), S337 - S337, Japanese
    [Refereed]
    Research society

  • 当院における食道癌に対する化学放射線治療の遡及的検討
    Yoshida Kenji, Miyawaki Daisuke, Sasaki Ryohei
    (公社)日本医学放射線学会, Feb. 2012, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 51 - 51, Japanese
    [Refereed]
    Research society

  • 転移性肺腫瘍に対する粒子線治療成績の検討
    Miyawaki Daisuke, Sasaki Ryohei
    (公社)日本医学放射線学会, Feb. 2012, 日本医学放射線学会学術集会抄録集, 71回(71回) (71回), S220 - S221, Japanese
    [Refereed]
    Research society

  • 耳下腺癌術後症例に対する放射線療法の経験
    Miyawaki Daisuke, Yoshida Kenji, Sasaki Ryohei, Ohtsuki Naoki, Nibu Ken-ichi, Okamoto Yoshiaki
    (公社)日本医学放射線学会, Feb. 2012, 日本医学放射線学会学術集会抄録集, 71回(71回) (71回), S314 - S314, Japanese
    [Refereed]
    Research society

  • 骨転移痛に対するストロンチウム-89の初期使用経験
    Yoshida Kenji, Uezono Haruka, Miyawaki Daisuke, Sasaki Ryohei, Sugimura Kazuro
    (公社)日本医学放射線学会, Feb. 2012, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 39 - 39, Japanese
    [Refereed]
    Research society

  • 胸部食道癌の治療計画における不均質補正の影響
    Sasaki Ryohei, Okamoto Yoshiaki, Kawabe Tetsuya, Yoshida Kenji, Miyawaki Daisuke, Sugimura Kazuro
    (公社)日本医学放射線学会, Feb. 2012, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 39 - 39, Japanese
    [Refereed]
    Research society

  • 眼付属器MALTリンパ腫の放射線治療成績の検討
    Yoshida Kenji, Miyawaki Daisuke, Sasaki Ryohei, Ejima Yasuo
    (公社)日本医学放射線学会, Feb. 2012, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 45 - 45, Japanese
    [Refereed]
    Research society

  • 拡散テンソル画像を用いた悪性グリオーマに対する強度変調放射線治療の検討
    Yoshida Kenji, Miyawaki Daisuke, Sasaki Ryohei
    (公社)日本医学放射線学会, Feb. 2012, Japanese Journal of Radiology, 30(Suppl.I) (Suppl.I), 45 - 45, Japanese
    [Refereed]
    Research society

  • T1-T3N0声門癌の喉頭温存を目指した治療方針の検討
    Sasaki Ryohei, Yoshida Kenji, Miyawaki Daisuke, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki
    (公社)日本医学放射線学会, Feb. 2012, 日本医学放射線学会学術集会抄録集, 71回(71回) (71回), S190 - S190, Japanese
    [Refereed]
    Research society

  • Ryohei Sasaki, Koichi Yasuda, Eisuke Abe, Nobue Uchida, Mitsuhiko Kawashima, Takashi Uno, Masayuki Fujiwara, Yoshiyuki Shioyama, Yoshikazu Kagami, Yuta Shibamoto, Kensei Nakata, Yoshie Takada, Tetsuya Kawabe, Kazuyuki Uehara, Kenichi Nibu, Syogo Yamada
    Feb. 2012, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 82(2) (2), 626 - 634, English
    [Refereed]
    Scientific journal

  • Takanobu Shimada, Naomi Kiyota, Hideki Nishimura, Naoki Otsuki, Ryohei Sasaki, Ken-ichi Nibu
    2012, Japanese Journal of Head and Neck Cancer, 38(3) (3), 374 - 379, Japanese
    [Refereed]
    Scientific journal

  • Yukihisa Tamaki, Teisuke Hashimoto, Takao Kamai, Koichi Honma, Yasuo Ejima, Erena Yamazaki, Rika Yoshida, Hiroaki Arakawa, Shigeko Kuwashima, Yasushi Kaji, Ryohei Sasaki, Kazuro Sugimura
    Nov. 2011, CLINICAL NUCLEAR MEDICINE, 36(11) (11), 1025 - 1028, English
    [Refereed]

  • Shohei Komatsu, Takumi Fukumoto, Yusuke Demizu, Daisuke Miyawaki, Kazuki Terashima, Ryohei Sasaki, Yuichi Hori, Yoshio Hishikawa, Yonson Ku, Masao Murakami
    Nov. 2011, Cancer, 117(21) (21), 4890 - 904, English, International magazine
    [Refereed]
    Scientific journal

  • Kenji Yoshida, Ryohei Sasaki, Hideki Nishimura, Daisuke Miyawaki, Tetsuya Kawabe, Yoshiaki Okamoto, Koji Nakabayashi, Shigeki Yoshida, Kazuro Sugimura
    Oct. 2011, Archives of gynecology and obstetrics, 284(4) (4), 1007 - 14, English, International magazine
    [Refereed]
    Scientific journal

  • Shohei Komatsu, Takumi Fukumoto, Yusuke Demizu, Daisuke Miyawaki, Kazuki Terashima, Yasue Niwa, Masayuki Mima, Osamu Fujii, Ryohei Sasaki, Isamu Yamada, Yuichi Hori, Yoshio Hishikawa, Mitsuyuki Abe, Yonson Ku, Masao Murakami
    Jul. 2011, Journal of gastroenterology, 46(7) (7), 913 - 20, English, Domestic magazine
    [Refereed]
    Scientific journal

  • 【治療に伴う看護特集 一問一答でいちからわかる、きちんとわかる!がん放射線療法と看護】 患者説明のための見通しを知ろう 放射線治療の有害事象
    Sasaki Ryohei, 橋本直樹, 赤坂浩亮
    メディカ出版, Apr. 2011, プロフェッショナルがんナーシング, 1(2号) (2号), 225 - 235, Japanese
    [Refereed][Invited]
    Scientific journal

  • Hideki Nishimura, Ryohei Sasaki, Takeshi Yoshida, Daisuke Miyawaki, Naki Otsuki, Miki Sitou, Naomi Kiyota, Synsuke Soejima, Kajurou Sugimura, Ken-ichi Nibu
    2011, Japanese Journal of Head and Neck Cancer, 37(1) (1), 62 - 66, Japanese
    [Refereed]
    Scientific journal

  • Masao Murakami, Yusuke Demizu, Yasue Niwa, Osamu Fujii, Kazuki Terashima, Masayuki Mima, Daisuke Miyawaki, Ryohei Sasaki, Yoshio Hishikawa, Mitsuyuki Abe
    2011, APPLICATION OF ACCELERATORS IN RESEARCH AND INDUSTRY: TWENTY-FIRST INTERNATIONAL CONFERENCE, 1336, 374 - 376, English
    [Refereed]
    International conference proceedings

  • 放射線治療の有害事象
    Sasaki Ryohei
    2011, プロフェッショナルがんナーシング, 1巻, pp. 63-73, Japanese
    International conference proceedings

  • Tomohisa Shibata, Kouichiro Yonezawa, Koichi Morimoto, Daisuke Yamashita, Naoki Otsuki, Hideki Nishimura, Ryohei Sasaki, Ken-ichi Nibu
    2011, Japanese Journal of Head and Neck Cancer, 37(1) (1), 78 - 82, Japanese
    [Refereed]
    Scientific journal

  • がん放射線治療の基礎知識
    Sasaki Ryohei
    2011, プロフェッショナルがんナーシング, 1巻, pp. 42-55, Japanese
    International conference proceedings

  • Toshinori Soejima, Eisaku Yoden, Yasumasa NIshimura, Seiji Ono, Akihiro Yoshida, Haruyuki Fukuda, Noboru Fukuhara, Ryohei Sasaki, Kayoko Tsujino, Yoshiki Norihisa
    2011, Journal of radiation research, 52(4) (4), 516 - 21, English, International magazine
    [Refereed]
    Scientific journal

  • Kanako Wakahashi, Manabu Shimoyama, Yoshio Katayama, Kentaro Minagawa, Kenji Yoshida, Ryohei Sasaki, Shunji Nakayama, Hiroshi Yokozaki, Emmy Yanagita, Tomoo Itoh, Yoshitake Hayashi, Toshimitsu Matsui
    Nov. 2010, INTERNATIONAL JOURNAL OF HEMATOLOGY, 92(4) (4), 642 - 646, English
    [Refereed]
    Scientific journal

  • Kanako Wakahashi, Manabu Shimoyama, Yoshio Katayama, Kentaro Minagawa, Kenji Yoshida, Ryohei Sasaki, Shunji Nakayama, Hiroshi Yokozaki, Emmy Yanagita, Tomoo Itoh, Yoshitake Hayashi, Toshimitsu Matsui
    This report is a case of histiocytic sarcoma (HS), in which tumor cells consist of two immunohistopathologically distinct populations (A) oval CD68+lysozyme+CD163- cells and (B) abundant cytoplasm or spindle-shaped CD68+lysozyme-CD163+ cells. Cervical lymph node was infiltrated mainly by population (A), where chemotherapy was quite effective. On the other hand, vast majority of infiltrated tumor cells in the hilar lymph node belonged to population (B), in which the cells were resistant to chemo-radiotherapy. Considering the poor prognosis of HS, the expression of CD163 could be a marker for resistance to chemo-radiotherapy. It is also notable that CD163-negative stage of HS may exist and still be reactive for the treatment.
    Nov. 2010, International journal of hematology, 92(4) (4), 642 - 6, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Hideyo Mukubou, Toshiaki Tsujimura, Ryohei Sasaki, Yonson Ku
    Autophagy has recently emerged as a significant mechanism in cancer treatment. Although gemcitabine and/or ionizing radiation are important modalities in the treatment of pancreatic cancer, the contribution of autophagy in such treatment has not been fully elucidated. This study investigated the role of autophagy in the treatment of pancreatic cancer with gemcitabine and ionizing radiation. To evaluate the effect of gemcitabine and/or ionizing radiation on autophagy, several human pancreatic cancer cell lines were used. The treatment of pancreatic cancer cell cultures in vitro and in vivo with gemcitabine and ionizing radiation resulted in synergistic cytotoxicity. After treatment with gemcitabine, the autophagy-related protein light chain 3-II (LC3-II) was upregulated. When gemcitabine was combined with ionizing radiation treatment, LC3-II upregulation was enhanced. In addition, electron microscopy of pancreatic cancer cells treated with gemcitabine and/or ionizing radiation detected the induction of autophagy. The blockage of autophagy by 3-methyladenine indicated that autophagy contributed to cell death after gemcitabine treatment and enhanced its cytotoxicity. The inhibitory effect and immune reactivity of the autophagy-related proteins LC3 and beclin-1 were the strongest after the combination treatment. In conclusion, these results suggest that autophagy can be activated by gemcitabine and/or ionizing radiation in the treatment of pancreatic cancer cells and that activated autophagy plays a role in cancer suppression. These findings may have important implications for future therapeutic strategies using gemcitabine and ionizing radiation against pancreatic cancer.
    Oct. 2010, International journal of oncology, 37(4) (4), 821 - 8, English, International magazine
    [Refereed]

  • Hideyo Mukubou, Toshiaki Tsujimura, Ryohei Sasaki, Yonson Ku
    Oct. 2010, INTERNATIONAL JOURNAL OF ONCOLOGY, 37(4) (4), 821 - 828, English, International magazine
    Scientific journal

  • Vitamin K2-derived compounds induce growth inhibition in radioresistant cancer cells.
    Helfi Amalia, Ryohei Sasaki, Yoko Suzuki, Yusuke Demizu, Toshinori Bito, Hideki Nishimura, Yoshiaki Okamoto, Kenji Yoshida, Daisuke Miyawaki, Tetsuya Kawabe, Yoshiyuki Mizushina, Kazuro Sugimura
    A strategy to overcome radioresistance in cancer treatment has been expected. To evaluate the strategy, appropriate experimental models are needed. Radioresistant tumour models were originally established from human colon cancer cells, and we evaluated their molecular basis. Next, the growth inhibitory effects of newly synthesized vitamin K2 (VK2)-related compounds were tested. Here, we showed that these novel compounds have growth inhibitory effects not only on cancer cells of various origins, but also on radioresistant cells, through the generation of reactive oxygen species (ROS). Human colon, lung, and breast cancer cell lines were used for testing the growth inhibitory activities of several chemical compounds. Radioresistant tumour models were established by fractionated radiation exposure. Irradiated cells were selected by a single cell cloning method, and their sensitivity to ionizing radiation was evaluated by a colony-forming assay. The VK2 derivatives (named MQ-1, MQ-2, and MQ-3) were chemically synthesized. To evaluate the generation of ROS, flow cytometer analyses were performed. A radioresistant tumour model was established from the HCT116 human colon cancer cell line. The radioresistant cells from HCT116 also showed resistance to cisplatin. In the radioresistant cells, NF-κB was highly activated. MQ-1, MQ-2, and MQ-3 showed greater growth inhibitory activities than VK2 not only in various cancer cells but also in radioresistant cells through the generation of ROS. In conclusion, a radioresistant tumour model was originally established from colon cancer cell lines through NF-κB activation, and it could be a useful tool for evaluating anti-tumour agents. Newly synthesized VK2 derivatives (MQ-1, MQ-2 and MQ-3) seemed to be potential anti-tumour agents in various cancers and radioresistant cancers. The efficacy of those compounds was related to the generation of ROS. These findings together might pave the way for the treatment of radioresistant or recurrent cancers.
    Sep. 2010, The Kobe journal of medical sciences, 56(2) (2), E38-49 - 49, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 当院における後期高齢者食道癌の内科的及び外科的治療の成績について
    Nishimura Hideki, Sasaki Ryohei, Kuroda Daisuke, Azuma Takeshi
    Sep. 2010, 日本癌治療学会誌, 45巻, 2号, pp. 522-522, Japanese
    International conference proceedings

  • 過酸化チタンナノ粒子及び低線量X線照射を併用した深部ガンの非侵襲的治療法の開発
    Sasaki Ryohei
    日本生物工学会, Sep. 2010, 日本生物工学会大会講演要旨集平成22年度, 巻, , pp. 168-168, 168 - 168, Japanese
    International conference proceedings

  • 1/2期子宮頸癌に対する根治的放射線治療の遡及的解析
    Nishimura Hideki, Miyawaki Daisuke, Sasaki Ryohei, Morita Hiroki
    (一社)日本癌治療学会, Sep. 2010, 日本癌治療学会誌, 45巻, 2号, pp. 1044-1044(2) (2), 1044 - 1044, Japanese
    [Refereed]
    International conference proceedings

  • 頭頸部領域の髄外性形質細胞腫の放射線治療の検討
    Sasaki Ryohei, Nishimura Hideki
    Jul. 2010, Japanese Journal of Radiology, 28巻, Suppl.I, pp. 50-50, Japanese
    International conference proceedings

  • 【放射線治療の最先端(前編)】 PET診断と放射線治療
    Sasaki Ryohei
    寺田国際事務所先端医療技術研究所, Jun. 2010, PET Journal, 巻, 10号, pp. 13-15(11) (11), 29 - 31, Japanese
    Scientific journal

  • 1/2期子宮頸癌に対する根治的放射線治療の遡及的解析
    Nishimura Hideki, Miyawaki Daisuke, Sasaki Ryohei, Morita Hiroki
    (公社)日本婦人科腫瘍学会, Jun. 2010, 日本婦人科腫瘍学会雑誌, 28巻, 3号, pp. 290-290(3) (3), 290 - 290, Japanese
    [Refereed]
    International conference proceedings

  • 嗅神経芽細胞腫に対する粒子線治療成績
    Miyawaki Daisuke, Nishimura Hideki, Morimoto Koichi, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2010, 頭頸部癌, 36巻, 2号, pp. 178-178(2) (2), 178 - 178, Japanese
    [Refereed]
    International conference proceedings

  • 放射線治療が施行された喉頭悪性リンパ腫の3例
    Nishimura Hideki, Miyawaki Daisuke, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2010, 頭頸部癌, 36巻, 2号, pp. 256-256(2) (2), 256 - 256, Japanese
    [Refereed]
    International conference proceedings

  • 同時併用化学放射線療法を行った中咽頭癌患者に対する嚥下リハビリテーションの有用性
    Morimoto Koichi, Doi Kiyoshi, Tanimoto Hitoshi, Sasaki Ryohei
    May 2010, 頭頸部癌, 36巻, 2号, pp. 177-177, Japanese
    International conference proceedings

  • 頭頸部原発・髄外性形質細胞腫に対する放射線治療成績の多施設調査研究
    Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2010, 頭頸部癌, 36巻, 2号, pp. 212-212(2) (2), 212 - 212, Japanese
    International conference proceedings

  • 当科における耳下腺癌の治療成績
    Morimoto Koichi, Doi Kiyoshi, Nishimura Hideki, Sasaki Ryohei
    May 2010, 頭頸部癌, 36巻, 2号, pp. 214-214, Japanese
    International conference proceedings

  • 当院に於ける中咽頭癌の放射線治療成績
    Miyawaki Daisuke, Nishimura Hideki, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2010, 頭頸部癌, 36巻, 2号, pp. 249-249(2) (2), 249 - 249, Japanese
    [Refereed]
    International conference proceedings

  • 当院における頭頸部腺様嚢胞腺癌に対する術後放射線治療の遡及的検討
    Nishimura Hideki, Miyawaki Daisuke, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2010, 頭頸部癌, 36巻, 2号, pp. 215-215(2) (2), 215 - 215, Japanese
    [Refereed]
    International conference proceedings

  • 超選択的動注法を用いた化学放射線療法後のsalvage手術後に胸鎖関節骨髄炎を来たし治療に難渋した1症例
    Sasaki Ryohei, Tahara Shinya
    May 2010, 頭頸部癌, 36巻, 2号, pp. 181-181, Japanese
    [Refereed]
    Scientific journal

  • 原発不明癌頸部リンパ節転移に対する治療経験
    Nishimura Hideki, Miyawaki Daisuke, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2010, 頭頸部癌, 36巻, 2号, pp. 179-179(2) (2), 179 - 179, Japanese
    [Refereed]
    International conference proceedings

  • 下咽頭癌に対する術後放射線治療の遡及的検討
    Nishimura Hideki, Miyawaki Daisuke, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2010, 頭頸部癌, 36巻, 2号, pp. 211-211(2) (2), 211 - 211, Japanese
    [Refereed]
    International conference proceedings

  • Kenji Yoshida, Ryohei Sasaki, Hideki Nishimura, Yoshiaki Okamoto, Yoko Suzuki, Tetsuya Kawabe, Miki Saito, Naoki Otsuki, Yoshitake Hayashi, Toshinori Soejima, Kenichi Nibu, Kazuro Sugimura
    BACKGROUND: The aim of this study was to evaluate the significance of nuclear factor-kappa B (NF-kappaB) expression as a marker of radioresistance in early-stage laryngeal cancer. METHODS: Thirty-five patients with local recurrence and 70 case-matched patients without local recurrence were entered in this study. NF-kappaB expression was compared with Bcl-2 and epidermal growth factor (EGF) receptor expression by immunohistochemistry, using pretreatment biopsy specimens. The prognostic value of NF-kappaB was also evaluated. Twenty-nine recurrent tumors were compared with pretreatment tumors. RESULTS: NF-kappaB expression in pretreatment tumors significantly correlated with local tumor control (p = .01), but bcl-2 and EGF receptor expression did not. Only NF-kappaB expression showed prognostic significance for local tumor control in both univariate and multivariate analyses (p = .008 and .04, respectively). NF-kappaB expression was markedly enhanced in 23 of 29 (80%) recurrent tumors. CONCLUSION: NF-kappaB expression may be a novel marker of radioresistance in early-stage laryngeal cancer.
    May 2010, Head & neck, 32(5) (5), 646 - 55, English, International magazine
    [Refereed]
    Scientific journal

  • Yuko Kumamoto-Yonezawa, Ryohei Sasaki, Yoko Suzuki, Yuki Matsui, Takahiko Hada, Keisuke Uryu, Kazuro Sugimura, Hiromi Yoshida, Yoshiyuki Mizushina
    We previously found that conjugated eicosapentaenoic acid (cEPA) selectively inhibited the activities of mammalian DNA polymerases (pols), and suppressed human cancer cell growth. The aim of the present study was to evaluate the efficacy of concurrent radiation with cEPA in a human colon carcinoma cell line, HCT 116. Furthermore, we examined the most effective timing of irradiation. The post-irradiation addition of cEPA significantly enhanced HCT116 cell radiosensitivity by decreasing the expression of pols beta, delta and epsilon, increasing damaged DNA, such as DNA double-strand breaks, inhibiting clonogenic survival, and inducing apoptosis. However, cells treated by pre-irradiation addition of cEPA did not influence radiosensitive survival and radiation-induced apoptosis. cEPA inhibited the activities of pols needed for DNA repair, thereby DNA damage must be augmented by cEPA and irradiation. These results suggested that the combination of inhibitors of DNA repair-related pols/radiation could be an effective anticancer therapy.
    Mar. 2010, International journal of oncology, 36(3) (3), 577 - 84, English, International magazine
    [Refereed]

  • Yuko Kumamoto-Yonezawa, Ryohei Sasaki, Yoko Suzuki, Yuki Matsui, Takahiko Hada, Keisuke Uryu, Kazuro Sugimura, Hiromi Yoshida, Yoshiyuki Mizushina
    Mar. 2010, INTERNATIONAL JOURNAL OF ONCOLOGY, 36(3) (3), 577 - 584, English, International magazine
    [Refereed]
    Scientific journal

  • 放射線治療 頭頸部腫瘍 喉頭癌
    Sasaki Ryohei
    Feb. 2010, 日本医学放射線学会学術集会抄録集, 巻, 69回, pp. S110-S110, Japanese
    International conference proceedings

  • 放射線治療が施行された喉頭悪性リンパ腫の3例
    Nishimura Hideki, Miyawaki Daisuke, Sasaki Ryohei
    (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 巻, 69回, pp. S266-S266, S266 - S266, Japanese
    [Refereed]
    International conference proceedings

  • 頭蓋内germ cell tumorに対する放射線治療成績
    Sasaki Ryohei, Miyawaki Daisuke, Nishimura Hideki
    (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 69回, S322 - S322, Japanese
    [Refereed]
    International conference proceedings

  • 頭蓋底脊索腫に対する粒子線治療
    Miyawaki Daisuke, Sasaki Ryohei
    (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 巻, 69回, pp. S268-S268, S268 - S268, Japanese
    [Refereed]
    International conference proceedings

  • 当院における中枢神経原発悪性リンパ腫に対する放射線治療の遡及的検討
    Sasaki Ryohei, Nishimura Hideki, Miyawaki Daisuke, Kohmura Eiji
    (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 巻, 69回, pp. S323-S323, S323 - S323, Japanese
    [Refereed]
    International conference proceedings

  • 高齢子宮頸癌患者に対する放射線治療の経験
    Sasaki Ryohei, Nishimura Hideki, Miyawaki Daisuke
    (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 巻, 69回, pp. S361-S361, S361 - S361, Japanese
    [Refereed]
    International conference proceedings

  • 局所進行下咽頭癌に対する術後照射の遡及的検討
    Nishimura Hideki, Sasaki Ryohei, Miyawaki Daisuke
    (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 巻, 69回, pp. S372-S372, S372 - S372, Japanese
    [Refereed]
    International conference proceedings

  • Hitoshi Ikushima, Lei Dong, Jeremy Erasmus, Pamela Allen, Mary F McAleer, Yan Zhuang, Ryohei Sasaki, Ritsuko Komaki
    The purpose of this study is to assess predictive value of the positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) for recurrence and survival after radiotherapy (RT) for non-small cell lung cancer (NSCLC). One hundred forty-nine patients underwent pretreatment PET (n = 67) or PET/computed tomography (CT) (n = 82) and definitive RT for NSCLC. We evaluated the relationship between the maximum-pixel standardized uptake value (SUV(max)) and clinical tumor features. Univariate Cox proportional hazard analysis (UVA) was used to quantify the risk for local-regional recurrence, distant metastases, and death. Multivariate Cox proportional hazard analysis (MVA) was used to assess the potential independent effect of SUV(max). In the PET group, T1 tumors showed significantly lower SUV(max) than T2, T3, and T4 tumors; in the PET/CT group, T1 tumors showed significantly lower SUV(max) than T3 and T4 tumors. A high SUV(max )was a negative factor for local-regional control (LRC) (p < 0.001), distant metastasis-free survival (DMFS) (p = 0.02), and overall survival (OS) (p = 0.001) on UVA in the PET group. However, the significance decreased to 0.05 for LRC, 0.04 for DMFS, and 0.04 for OS by MVA when tumor size was included in the analysis. A high SUV(max) was not a negative factor for LRC, DMFS, or OS on UVA and MVA in the PET/CT group. In conclusion, assessment of predictive value of SUV(max) for NSCLC requires consideration of primary tumor size, and the evidence is not sufficient to suggest that FDG uptake in a primary NSCLC provides prognostic information.
    2010, Journal of radiation research, 51(4) (4), 465 - 71, English, International magazine
    [Refereed]
    Scientific journal

  • Yusuke Demizu, Masao Murakami, Daisuke Miyawaki, Yasue Niwa, Takashi Akagi, Ryohei Sasaki, Kazuki Terashima, Daisaku Suga, Isao Kamae, Yoshio Hishikawa
    PURPOSE: To assess the incident rates of vision loss (VL; based on counting fingers or more severe) caused by radiation-induced optic neuropathy (RION) after particle therapy for tumors adjacent to optic nerves (ONs), and to evaluate factors that may contribute to VL. METHODS AND MATERIALS: From August 2001 to August 2006, 104 patients with head-and-neck or skull-base tumors adjacent to ONs were treated with carbon ion or proton radiotherapy. Among them, 145 ONs of 75 patients were irradiated and followed for greater than 12 months. The incident rate of VL and the prognostic factors for occurrence of VL were evaluated. The late effects of carbon ion and proton beams were compared on the basis of a biologically effective dose at alpha/beta = 3 gray equivalent (GyE(3)). RESULTS: Eight patients (11%) experienced VL resulting from RION. The onset of VL ranged from 17 to 58 months. The median follow-up was 25 months. No significant difference was observed between the carbon ion and proton beam treatment groups. On univariate analysis, age (>60 years), diabetes mellitus, and maximum dose to the ON (>110 GyE(3)) were significant, whereas on multivariate analysis only diabetes mellitus was found to be significant for VL. CONCLUSIONS: The time to the onset of VL was highly variable. There was no statistically significant difference between carbon ion and proton beam treatments over the follow-up period. Based on multivariate analysis, diabetes mellitus correlated with the occurrence of VL. A larger study with longer follow-up is warranted.
    Dec. 2009, International journal of radiation oncology, biology, physics, 75(5) (5), 1487 - 92, English, International magazine
    [Refereed]
    Scientific journal

  • 日常診療の指針 直腸癌に対する術前化学放射線療法の試み
    Nishimura Hideki, Sasaki Ryohei
    (株)永井書店, Nov. 2009, 外科治療, 101(5) (5), 607 - 608, Japanese
    Scientific journal

  • 下部直腸癌に対する術前化学放射線療法
    Nishimura Hideki, Sasaki Ryohei
    (株)癌と化学療法社, Nov. 2009, 癌と化学療法, 36(12) (12), 2006 - 2008, Japanese
    [Refereed]
    Scientific journal

  • Daisuke Miyawaki, Masao Murakami, Yusuke Demizu, Ryohei Sasaki, Yasue Niwa, Kazuki Terashima, Hideki Nishimura, Yoshio Hishikawa, Kazuro Sugimura
    PURPOSE: To assess the incidence of early delayed or late morbidity of the brain after particle therapy for skull base tumors and head-and-neck cancers. METHODS AND MATERIALS: Between May 2001 and December 2005, 59 patients with cancerous invasion of the skull base were treated with proton or carbon ion therapy at the Hyogo Ion Beam Medical Center. Adverse events were assessed according to the magnetic resonance imaging findings (late effects of normal tissue-subjective, objective, management, analytic [LENT-SOMA]) and symptoms (Common Terminology Criteria for Adverse Events [CTCAE], version 3.0). Dose-volume histograms were used to analyze the relationship between the dose and volume of the irradiated brain and the occurrence of brain injury. The median follow-up time was 33 months. RESULTS: Of the 48 patients treated with proton therapy and 11 patients treated with carbon ion radiotherapy, 8 (17%) and 7 (64%), respectively, developed radiation-induced brain changes (RIBCs) on magnetic resonance imaging (LENT-SOMA Grade 1-3). Four patients (7%) had some clinical symptoms, such as vertigo and headache (CTCAE Grade 2) or epilepsy (CTCAE Grade 3). The actuarial occurrence rate of RIBCs at 2 and 3 years was 20% and 39%, respectively, with a significant difference in the incidence between the proton and carbon ion radiotherapy groups. The dose-volume histogram analyses revealed significant differences between the brain lobes with and without RIBCs in the actuarial volume of brain lobes receiving high doses. CONCLUSION: Particle therapies produced minimal symptomatic brain toxicities, but sequential evaluation with magnetic resonance imaging detected a greater incidence of RIBCs. Significant differences were observed in the irradiated brain volume between the brain lobes with and without RIBCs.
    Oct. 2009, International journal of radiation oncology, biology, physics, 75(2) (2), 378 - 84, English, International magazine
    [Refereed]
    Scientific journal

  • Masakazu Shimizu, Ryohei Sasaki, Daisuke Miyawaki, Hideki Nishimura, Yusuke Demizu, Takashi Akagi, Daisaku Suga, Hidenobu Sakamoto, Masao Murakami, Kazuro Sugimura, Yoshio Hishikawa
    PURPOSE: Proton therapy is a sophisticated treatment modality for prostate cancer. We investigated how physiologic factors affected the distribution of autoactivation as detected by positron emission tomography (PET) after proton beam therapy. METHODS AND MATERIALS: Autoactivation was evaluated in 59 patients treated with a 210-MeV proton beam. Data acquisition for autoactivation by PET started 5 minutes after proton irradiation to assess activation. In the first 29 patients, five regions of interest were evaluated: planning target volume (PTV) center, urinary bladder inside the PTV, urinary bladder outside the PTV, rectum (outside the PTV), and contralateral femoral bone head (outside the PTV). In the remaining 30 patients, urine activity was measured directly. In a phantom study autoactivation and its diffusion after proton beam irradiation were evaluated with water or an ice block. RESULTS: Mean activities calculated by use of PET were 629.3 Bq in the PTV center, 555.6 Bq in the urinary bladder inside the PTV, 332.5 Bq in the urinary bladder outside the PTV, 88.4 Bq in the rectum, and 23.7 Bq in the femoral bone head (p < 0.001). Mean urine activity was 679.4 Bq, recorded 10 minutes after therapy completion, and the half-life for urine autoactivation was 4.5 minutes. CONCLUSIONS: Urine is a major diffusion mediator of autoactivation after proton beam therapy. Our results indicate that physiologic factors can influence PET images of autoactivation in the context of proton beam therapy verification.
    Oct. 2009, International journal of radiation oncology, biology, physics, 75(2) (2), 580 - 6, English, International magazine
    [Refereed]
    Scientific journal

  • Sasaki Ryohei
    金原出版(株), Oct. 2009, 臨床放射線, 54巻, 10号, pp. 1211-1216(10) (10), 1211 - 1216, Japanese
    [Refereed]
    Scientific journal

  • 頭蓋底脊索腫に対する粒子線治療
    Miyawaki Daisuke, Sasaki Ryohei
    (一社)日本癌治療学会, Sep. 2009, 日本癌治療学会誌, 44巻, 2号, pp. 532-532(2) (2), 532 - 532, Japanese
    [Refereed]
    International conference proceedings

  • 聴器扁平上皮癌に対する治療経験
    Sasaki Ryohei, Nishimura Hideki, Miyawaki Daisuke
    (一社)日本癌治療学会, Sep. 2009, 日本癌治療学会誌, 44巻, 2号, pp. 798-798(2) (2), 798 - 798, Japanese
    [Refereed]
    International conference proceedings

  • 食道癌 T1aMM～T1bに対する治療戦略 当院での食道表在癌の内科治療と外科治療の治療成績の比較について
    Nishimura Hideki, Sasaki Ryohei, Kuroda Daisuke
    (一社)日本癌治療学会, Sep. 2009, 日本癌治療学会誌, 44(2) (2), 325 - 325, Japanese
    International conference proceedings

  • 局所進行直腸癌(T3/4)に対する治療戦略 リンパ節転移制御能からみたT3/T4下部直腸癌に対する術前化学放射線療法の検討
    Nishimura Hideki, Sasaki Ryohei, Kuroda Daisuke, Ku Yonson
    (一社)日本癌治療学会, Sep. 2009, 日本癌治療学会誌, 44(2) (2), 335 - 335, Japanese
    International conference proceedings

  • 【放射線治療の治療効果向上と副作用軽減を目指して】 新しい放射線増感剤の基礎と臨床 放射線抵抗性の規定因子 NF-Kappa Bの関与とその克服
    Sasaki Ryohei, Nishimura Hideki
    Jul. 2009, 癌の臨床, 55巻, 4号, pp. 239-244, Japanese
    [Refereed]
    Scientific journal

  • 鼻副鼻腔未分化癌10症例の粒子線治療成績
    Miyawaki Daisuke, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2009, 頭頸部癌, 35巻, 2号, pp. 145-145(2) (2), 145 - 145, Japanese
    [Refereed]
    International conference proceedings

  • 当院における下咽頭癌放射線治療の遡及的検討
    Nishimura Hideki, Sasaki Ryohei
    May 2009, 頭頸部癌, 35巻, 2号, pp. 83-83, Japanese
    International conference proceedings

  • 聴器扁平上皮癌に対する治療経験
    Sasaki Ryohei, Nishimura Hideki
    May 2009, 頭頸部癌, 35巻, 2号, pp. 79-79, Japanese
    International conference proceedings

  • 中咽頭癌に対する放射線治療の遡及的検討
    Sasaki Ryohei, Nishimura Hideki
    May 2009, 頭頸部癌, 巻, 352, pp. 96-96, Japanese
    International conference proceedings

  • 上咽頭癌に対する放射線化学療法の遡及的検討
    Sasaki Ryohei, Nishimura Hideki
    May 2009, 頭頸部癌, 35巻, 2号, pp. 93-93, Japanese
    International conference proceedings

  • Sasaki Ryohei, Sugimura Kazuro
    May 2009, Biochimica et biophysica acta, Vol. 1790, No. 5, pp. 339-46(5) (5), 339 - 346, English
    [Refereed]
    Scientific journal

  • 上咽頭癌放射線化学療法中に発症した5-FU脳症の一例
    Nishimura Hideki, Sasaki Ryohei
    Apr. 2009, Japanese Journal of Radiology, 27巻, Suppl., pp. 48-48, Japanese
    International conference proceedings

  • SASAKI Ryohei, NUMASAKI Hodaka, NISHIO Teiji, FUKUDA Haruyuki, ASHINO Yasuo, ONISHI Hiroshi, NAKAMURA Katsumasa, NAGATA Yasushi, TESHIMA Teruki
    The 4th JASTRO Future Planning Seminar was held in Tokyo on March 8, 2008. In the meeting, the approved plans for the Professional Training Plan for Cancer by the Ministry of Education, Culture, Sports, Science, and Technology, Japan, were introduced and discussed. Questionnaires on the contents of each plan, such as numbers/positions of students/ instructors, difficulty, problems, and opinions, were introduced and widely assessed. From the investigation, the small number of instructors who are medical physicists was identified as the most important problem for the future in the field of radiation oncology in Japan.
    Japanese Society for Therapeutic Radiology and Oncology, Mar. 2009, The Journal of JASTRO, 21(1) (1), 19 - 25, Japanese

  • 膵癌細胞を用いた化学放射線照射による細胞死のautophagy寄与に関する基礎的検討
    Sasaki Ryohei, Ku Yonson
    Feb. 2009, 日本外科学会雑誌, 110巻, 臨増2, pp. 227-227, Japanese
    International conference proceedings

  • 放射線肺線維症内部の照射野内再発の診断におけるFDG-PETの有用性の検討
    Sasaki Ryohei, Nishimura Hideki
    Feb. 2009, 日本医学放射線学会学術集会抄録集, 巻, 68回, pp. S207-S207, Japanese
    International conference proceedings

  • 当院に於ける中咽頭癌の放射線治療成績
    Sasaki Ryohei, Nishimura Hideki
    Feb. 2009, 日本医学放射線学会学術集会抄録集, 巻, 68回, pp. S196-S196, Japanese
    International conference proceedings

  • 当院における悪性神経膠腫の治療成績の遡及的検討
    Nishimura Hideki, Sasaki Ryohei
    (公社)日本医学放射線学会, Feb. 2009, 日本医学放射線学会学術集会抄録集, 68回, S332 - S333, Japanese
    International conference proceedings

  • 橋gliomaに対する放射線治療経験
    Sasaki Ryohei, Nishimura Hideki
    Feb. 2009, 日本医学放射線学会学術集会抄録集, 巻, 68回, pp. S194-S194, Japanese
    International conference proceedings

  • Preoperative chemoradiotherapy for resectable lower rectal cancer
    Shiro Takase, Takashi Kamigaki, Kimihiro Yamashita, Tetsu Nakamura, Hideki Nishimura, Ryohei Sasaki
    Japanese Journal of Cancer and Chemotherapy Publishers Inc., 2009, Japanese Journal of Cancer and Chemotherapy, 36(12) (12), 2006 - 2008, Japanese
    [Refereed]
    Scientific journal

  • Masanori Teshima, Hitoshi Tanimoto, Miki Saito, Naoki Otsuki, Ken-ichi Nibu, Ryohei Sasaki, Naomi Kiyota, Shinya Okuno
    2009, Toukeibu Gan, 35(3) (3), 287 - 292, English
    [Refereed]
    Scientific journal

  • 膵癌細胞を用いたGemcitabine、放射線照射とその併用による細胞死のautophagy寄与に関する基礎的検討
    Sasaki Ryohei, Ku Yonson
    Oct. 2008, 日本癌治療学会誌, 43巻, 2号, pp. 475-475, Japanese
    [Refereed]
    International conference proceedings

  • 当院に於ける上咽頭癌に対する治療方針の変遷
    Sasaki Ryohei, Nishimura Hideki, Ohtsuki Naoki
    Oct. 2008, 日本癌治療学会誌, 43巻, 2号, pp. 574-574, Japanese
    International conference proceedings

  • 早期喉頭癌(T1-T2N0M0)の局所制御におけるNF-κB発現の検討 他の生物学的マーカーとの比較
    Sasaki Ryohei, Nishimura Hideki, Ohtsuki Naoki
    Oct. 2008, 日本癌治療学会誌, 43巻, 2号, pp. 665-665, Japanese
    International conference proceedings

  • 声門癌放射線治療非制御例の検討
    Ohtsuki Naoki, Sasaki Ryohei, Nishimura Hideki
    Oct. 2008, 日本癌治療学会誌, 43巻, 2号, pp. 575-575, Japanese
    International conference proceedings

  • Takahiro Nakagawa, Naoki Otsuki, Yohko Masai, Ryohei Sasaki, Mamoru Tsukuda, Ken-Ichi Nibu
    CONCLUSION: The results presented here provide evidence of the enhancing effect of oral fluoropyrimidine derivative S-1 in concomitant chemoradiotherapy for head and neck cancer and further insights into its biological mechanism. OBJECTIVE: To investigate the additive effect of S-1 and radiation for human hypopharyngeal cancer. MATERIALS AND METHODS: Nude mice bearing hypopharyngeal cancer cells (H891) were used for an in vivo model. S-1 was administered at a volume of 0.01 mg/g body weight per mouse for 14 days, and tumors were irradiated with 2.0 Gy on days 1 and 8. Mice treated with either radiation or S-1 alone were used as controls. The growth of tumors in each group was measured and, after completion of the treatment, a focused DNA array was used to determine mRNA expression levels in the tumors of 132 genes related to 5-fluorouracil (5-FU), radiation or carcinogenesis. RESULTS: The additive antitumor effect of S-1 and radiation was statistically confirmed on day 14 (p=0.01). DNA array assay showed significant changes in expression of several genes, including DNA repair gene POLD, angiogenesis-related genes bFGF and TP, DNA topoisomerase TOP2A, and nucleoside transporter gene ENT1.
    Aug. 2008, Acta oto-laryngologica, 128(8) (8), 936 - 40, English, International magazine
    [Refereed]
    Scientific journal

  • 高線量率組織内照射による限局性前立腺癌患者のHealth-related Quality of Life(HRQoL)の変化 治療前後1年間の推移
    Sasaki Ryohei, Nishimura Hideki
    Jun. 2008, 日本放射線腫瘍学会誌, 20巻, 2号, pp. 90-90, Japanese
    International conference proceedings

  • 当科における上咽頭癌の治療成績
    Sasaki Ryohei, Nishimura Hideki
    May 2008, 頭頸部癌, 34巻, 2号, pp. 228-228, Japanese
    International conference proceedings

  • 下咽頭癌T1,T2症例の治療成績
    Ohtsuki Naoki, Sasaki Ryohei
    May 2008, 頭頸部癌, 34巻, 2号, pp. 199-199, Japanese
    International conference proceedings

  • Ryohei Sasaki, Yoko Suzuki, Yuko Yonezawa, Yosuke Ota, Yoshiaki Okamoto, Yusuke Demizu, Peng Huang, Hiromi Yoshida, Kazuro Sugimura, Yoshiyuki Mizushina
    May 2008, CANCER SCIENCE, 99(5) (5), 1040 - 1048, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yusuke Demizu, Ryohei Sasaki, Dunyaporn Trachootham, Helene Pelicano, Justin A. Colacino, Jinsong Liu, Peng Huang
    May 2008, ANTIOXIDANTS & REDOX SIGNALING, 10(5) (5), 951 - 961, English
    [Refereed]
    Scientific journal

  • 放射線治療が奏効した全身に多発する原発不明の肉腫の一例
    Nishimura Hideki, Sasaki Ryohei
    (公社)日本医学放射線学会, Apr. 2008, Radiation Medicine, 26(Suppl.I) (Suppl.I), 46 - 46, Japanese
    International conference proceedings

  • 肝細胞癌手術困難例に対する粒子線治療の意義
    Tominaga Masahiro, Kusunoki Nobuya, Sasaki Ryohei, Ku Yonson
    Apr. 2008, 日本外科学会雑誌, 109巻, 臨増2, pp. 257-257, Japanese
    [Refereed]
    International conference proceedings

  • Sasaki Ryohei
    (公社)日本放射線腫瘍学会, Mar. 2008, 日本放射線腫瘍学会誌, 20巻, 1号, pp. 29-35(1) (1), 29 - 35, Japanese
    Scientific journal

  • 頭頸部腺様嚢胞癌に対する粒子線治療 後ろ向き検討
    Sasaki Ryohei
    Feb. 2008, 日本医学放射線学会学術集会抄録集, 巻, 67回, pp. S259-S260, Japanese
    International conference proceedings

  • T1/T2NO喉頭癌の局所制御におけるNuclear Factor-Kappa B活性の影響についての検討
    Sasaki Ryohei
    Feb. 2008, 日本医学放射線学会学術集会抄録集, 巻, 67回, pp. S171-S171, Japanese
    International conference proceedings

  • 肝細胞癌に対する粒子線治療成績の検討
    Sasaki Ryohei
    Nov. 2007, 日本臨床外科学会雑誌, 68巻, 増刊, pp. 647-647, Japanese
    International conference proceedings

  • Hiroshi Mayahara, Masao Murakami, Kazufumi Kagawa, Atsuya Kawaguchi, Yasue Oda, Daisuke Miyawaki, Ryohei Sasaki, Kazuro Sugimura, Yoshio Hishikawa
    PURPOSE: To investigate the incidence and influencing factors of acute genitourinary (GU) and gastrointestinal morbidities in patients with prostate cancer treated with proton therapy. METHODS AND MATERIALS: A total of 287 patients with histologically proven Stage cT1-T4N0M0 prostate cancer were treated with proton therapy between 2003 and 2004. Of these, 204 (71%) received neoadjuvant androgen suppression therapy. The patients were treated with 190-230-MeV protons using lateral-opposed techniques to a dose of 74 GyE. Dose-volume histogram analyses were performed. The incidence of acute morbidity was evaluated using the National Cancer Institute Common Toxicity Criteria, version 2.0. Clinical factors, including age, clinical target volume, initial prostate-specific antigen level, T stage, presence of diabetes mellitus, and the use of androgen suppression therapy, were investigated to determine whether those affected the incidence of acute GU morbidity. RESULTS: None developed Grade 2 or higher acute gastrointestinal morbidity. In contrast, 111 (39%) and 4 (1%) patients experienced acute Grade 2 and Grade 3 GU morbidities, respectively. However, 87% of the patients were successfully relieved by the administration of a selective alpha-1 blocker. Multivariate analysis showed that a larger clinical target volume (p = 0.001) and the use of androgen suppression therapy (p = 0.017) were significant factors for the prediction of acute Grade 2-3 GU morbidity. CONCLUSION: In our experience with proton therapy, a low incidence of acute gastrointestinal morbidity was observed. In contrast, the incidence of acute GU morbidity was similar to that in other reports of photon radiotherapy. Additional follow-up is warranted to elucidate the long-term safety and efficacy of proton therapy for prostate cancer.
    Oct. 2007, International journal of radiation oncology, biology, physics, 69(2) (2), 434 - 43, English, International magazine
    [Refereed]
    Scientific journal

  • Sasaki Ryohei
    Sep. 2007, 日本放射線腫瘍学会誌, 19巻, 3号, pp. 165-169(3) (3), 165 - 169, Japanese
    [Refereed]
    Scientific journal

  • 神戸大学における遠隔画像診断について
    Sasaki Ryohei
    (公社)日本医学放射線学会, Apr. 2007, Radiation Medicine, 25巻, Suppl.I, pp. 79-79(Suppl.I) (Suppl.I), 79 - 79, Japanese
    International conference proceedings

  • 甲状腺分化癌に対する131I治療の初期経験
    Sasaki Ryohei
    Apr. 2007, Radiation Medicine, 25巻, Suppl.I, pp. 60-60, Japanese
    International conference proceedings

  • 胃に再発をきたした結膜原発MALTリンパ腫の1例
    Sasaki Ryohei
    (公社)日本医学放射線学会, Apr. 2007, Radiation Medicine, 25巻, Suppl.I, pp. 71-71(Suppl.I) (Suppl.I), 71 - 71, Japanese
    International conference proceedings

  • ペースメーカーおよびICD装着患者に対する放射線治療に関する予備アンケート報告
    Sasaki Ryohei
    Apr. 2007, Radiation Medicine, 25巻, Suppl.I, pp. 59-59, Japanese
    International conference proceedings

  • 1期/2期喉頭癌に対する根治的放射線治療成績
    SASAKI RYOHEI
    Feb. 2007, 日本医学放射線学会雑誌, 66回抄録集, pp. S237-S237, Japanese
    [Refereed]
    International conference proceedings

  • Impact of selective mitochondrial DNA polymerase gamma inhibition by vitamin K compounds against human cancer cells and radioresistant clones
    R. Sasaki, Y. Suzuki, Y. Ota, Y. Yonezawa, P. Huang, K. Yoshida, H. Nishimura, Y. Okamoto, K. Sugimura, V. Mizushina
    2007, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69(3) (3), S614 - S614, English
    [Refereed]
    International conference proceedings

  • Subacute central nervous system morbidity after proton therapy and carbon ion therapy against head and neck cancers and skull base tumors: Impact of sequential evaluation by MR imagings
    D. Miyawaki, M. Murakami, R. Sasaki, H. Nishimura, Y. Demizu, Y. Oda, K. Sugimura, Y. Hishikawa
    2007, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69(3) (3), S57 - S57, English
    [Refereed]
    International conference proceedings

  • Radiation therapy for early hypopharyngeal cancer
    H. Nishimura, R. Sasaki, Y. Okamoto, Y. Ota, K. Yoshida, K. Nibu, N. Otsuki, M. Saito, T. Soejima, K. Sugimura
    2007, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69(3) (3), S447 - S448, English
    [Refereed]
    International conference proceedings

  • Proton therapy and carbon ion therapy for patients with hepatocellular carcinoma: The hyogo ion beam medical center experience
    S. Komatsu, M. Murakami, T. Fukumoto, M. Tominaga, T. Iwasaki, D. Miyawaki, H. Nishimura, R. Sasaki, Y. Ku, Y. Hishikawa
    2007, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69(3) (3), S266 - S266, English
    [Refereed]
    International conference proceedings

  • Intraoperative radiotherapy for the abdominal lymph nodes in patients with esophageal carcinoma
    Y. Tamaki, L. Ogura, R. Sasaki, T. Nakajima, K. Yoshida, H. Nishimura, Y. Okamoto, Y. Okuno, M. Murakami, K. Sugimura
    2007, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69(3) (3), S282 - S282, English
    [Refereed]
    International conference proceedings

  • Impact of nuclear factor kappa B activity for local tumor controllability by radiotherapy in patients with T1/T2N0 laryngeal cancer
    K. Yoshida, R. Sasaki, Y. Okamoto, H. Nishimura, Y. Ejima, Y. Ota, M. Saitoh, N. Otsuki, K. Nibu, K. Sugimura
    2007, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69(3) (3), S436 - S436, English
    [Refereed]
    International conference proceedings

  • Confirmation of proton beam by positron emission tomography (PET) apparatus in patients with prostate cancer
    M. Shimizu, R. Sasaki, D. Miyawaki, H. Nishimura, Y. Demizu, T. Akagi, D. Suga, M. Murakami, K. Sugimura, Y. Hishikawa
    2007, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69(3) (3), S356 - S356, English
    [Refereed]
    International conference proceedings

  • Helene Pelicano, Rui-hua Xu, Min Du, Li Feng, Ryohei Sasaki, Jennifer S. Carew, Yumin Hu, Latha Ramdas, Limei Hu, Michael J. Keating, Wei Zhang, William Plunkett, Peng Huang
    Dec. 2006, JOURNAL OF CELL BIOLOGY, 175(6) (6), 913 - 923, English
    [Refereed]
    Scientific journal

  • Yusuke Demizu, Ryohei Sasaki, Toshinori Soejima, Tsutomu Maruta, Yoshiaki Okamoto, Kazunari Yamada, Eisaku Yoden, Yasuo Ejima, Yosuke Ota, Haruhiko Ishida, Kenichi Nibu, Kazuro Sugimura
    OBJECTIVE: To investigate the efficacy and feasibility of a cisplatin-based concurrent chemoradiotherapy (CRT) protocol based on Intergroup Study 0099 for nasopharyngeal carcinoma (NPC). METHODS: Sixteen patients with stage II-IVB NPC were treated with a protocol of cisplatin-based concurrent CRT and adjuvant chemotherapy from 1998 to 2002. Three courses of cisplatin (80 mg/m2) were scheduled during 70 Gy of radiotherapy (RT), and two agents of adjuvant chemotherapy (FP regimen: cisplatin 80 mg/m2 and 5-fluorouracil 800 mg/m2/day by 4-day continuous infusion) were challenged. Overall survival (OS) and relapse-free survival (RFS) rates were calculated by the Kaplan-Meier method. RESULTS: Median follow-up duration was 45 months. Both 3-year OS and RFS rates were 81%. Proportions of patients who tolerated each scheduled treatment were 94% for RT, 63% for concurrent chemotherapy and 38% for adjuvant chemotherapy. CONCLUSIONS: Our protocol of the cisplatin-based concurrent CRT followed by adjuvant chemotherapy consisting of FP regimen was effective for Japanese patients with NPC. However, the doses and numbers of cycle of chemotherapy need to be modified because of the low compliance rate. Larger numbers of data accumulation and/or multi-institutional trials may be warranted to confirm the efficacy of this protocol.
    Oct. 2006, Japanese journal of clinical oncology, 36(10) (10), 620 - 5, English, International magazine
    [Refereed]
    Scientific journal

  • SASAKI RYOHEI
    神戸大学, Aug. 2006, 神緑会学術誌, 22巻, pp. 108-110, 108 - 110, Japanese
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 炭素イオン線治療が奏効した肺肉腫の1例
    Sasaki Ryohei
    Aug. 2006, 肺癌, 46巻, 4号, pp. 385-385, Japanese
    International conference proceedings

  • 非小細胞肺癌におけるFDG-PETを用いた治療方針の決定とSUVの予後予測について MD Anderson Cancer Centerでの経験を中心に
    SASAKI RYOHEI
    May 2006, Radiology Frontier, 9巻, 2号, pp. 162-163, Japanese
    Scientific journal

  • M Higuchi, T Kudo, S Suzuki, TT Evans, R Sasaki, Y Wada, T Shirakawa, Sawyer, JR, A Gotoh
    Mar. 2006, ONCOGENE, 25(10) (10), 1437 - 1445, English
    Scientific journal

  • Yasuo Ejima, Ryohei Sasaki, Yoshiaki Okamoto, Tsutomu Maruta, Atsushi Azumi, Yoshitake Hayashi, Yusuke Demizu, Yosuke Ota, Toshinori Soejima, Kazuro Sugimura
    Forty-two patients with stage IE ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma were retrospectively analyzed. Five-year local control and progression-free survival rates were 100 and 77%, respectively. The most common relapsed site was the contralateral orbit. Thirty Gy of local irradiation seemed to be quite effective and safe.
    Jan. 2006, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 78(1) (1), 6 - 9, English, International magazine
    [Refereed]
    Scientific journal

  • Ken-ichi Nibu, Naoki Otsuki, Miki Saito, Ryohei Sasaki, Yoshiki Okamoto, Daisuke Shirasaka, Tatsuya Okuno
    2006, Toukeibu Gan, 32(3) (3), 328 - 331, English
    [Refereed]
    Scientific journal

  • Expressions of antioxidant molecules and ROS alterations in tobacco carcinogen-induced cancer cells with radioresistant phenotype
    Y. Demizu, R. Sasaki, D. Trachootham, P. Huang
    2006, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 66(3) (3), S584 - S585, English
    [Refereed]
    International conference proceedings

  • 放射線抵抗性腫瘍の樹立とその分子メカニズムの検討
    SASAKI, Ryohei, 出水祐介, OKAMOTO, Yoshiaki, 太田陽介, 江島泰生, 宮脇大輔, SUGIMURA, Kazuro
    (公社)日本放射線腫瘍学会, Oct. 2005, 日本放射線腫瘍学会誌, 17巻, Suppl.1, pp.161-161(Suppl.1) (Suppl.1), 161 - 161, Japanese
    International conference proceedings

  • 頭頸部食道二重癌に対する全頸部・T字同時照射の経験
    太田陽介, OKAMOTO, Yoshiaki, 宮脇大輔, 江島泰生, SASAKI, Ryohei, SOEJIMA,Toshinori, SUGIMURA, Kazuro
    (公社)日本放射線腫瘍学会, Oct. 2005, 日本放射線腫瘍学会誌, 17巻, Suppl.1, pp.118-118(Suppl.1) (Suppl.1), 118 - 118, Japanese
    International conference proceedings

  • 眼付属器マルトリンパ腫におけるBCL10蛋白発現と予後・病期との関連性
    江島泰生, SASAKI, Ryohei, OKAMOTO, Yoshiaki, 丸田力, 宮脇大輔, 太田陽介, SOEJIMA,Toshinori, SUGIMURA, Kazuro
    (公社)日本放射線腫瘍学会, Oct. 2005, 日本放射線腫瘍学会誌, 17巻, Suppl.1, pp.154-154(Suppl.1) (Suppl.1), 154 - 154, Japanese
    International conference proceedings

  • ペースメーカーおよびICD装着患者に対する放射線治療に関する予備アンケート報告
    Sasaki Ryohei
    Oct. 2005, 日本放射線腫瘍学会誌, 17巻, Suppl.1, pp. 151-151, Japanese
    International conference proceedings

  • G Achanta, R Sasaki, L Feng, JS Carew, WQ Lu, H Pelicano, MJ Keating, P Huang
    Oct. 2005, EMBO JOURNAL, 24(19) (19), 3482 - 3492, English
    [Refereed]
    Scientific journal

  • 当科における早期声門癌の治療成績
    木村真実, 齋藤幹, SASAKI, Ryohei, TANIMOTO, Hitoshi, 田中博紀, SHIMIZU,Kenichiro, MOHRI,Mitsuhiro, 木西實, AMATSU,Mutsuo, NIBU, Kenichi
    May 2005, 頭頸部癌, 31巻, 2号, pp.216-216, Japanese
    International conference proceedings

  • Joe Y Chang, Ritsuko Komaki, Ryohei Sasaki, Zhongxing Liao, Craig W Stevens, Charles Lu, Frank V Fossella, Pamela K Allen, James D Cox, Margaret R Spitz, Xifeng Wu
    PURPOSE: To investigate whether the bleomycin sensitivity assay, an in vitro peripheral blood lymphocyte assay, can predict outcome in patients with inoperable stage III non-small-cell lung cancer (NSCLC) treated with definitive radiotherapy and chemotherapy. EXPERIMENTAL DESIGN: We identified 102 patients with inoperable stage III NSCLC cell lung cancer treated with definitive radiotherapy and chemotherapy. The patients' pretreatment peripheral blood lymphocyte cultures were treated with the radiomimetic mutagen bleomycin. An index of bleomycin sensitivity was determined by counting the number of chromatid breaks in 50 metaphases. The correlation between bleomycin sensitivity (expressed as mean breaks per cell) and clinical outcome was analyzed. RESULTS: High bleomycin sensitivity (defined as a mean of >1.02 chromatid breaks/cell, representing the third quartile of bleomycin sensitivity) predicted poor disease-specific survival and overall survival. The 6-year disease-specific survival was 27% in patients with high bleomycin sensitivity compared with 46% in patients without such sensitivity (P = 0.0094). The association remained statistically significant when adjusted for smoking status, age, and radiation dose. The 6-year overall survival was 19% for patients with high bleomycin sensitivity and 29% for those without (P = 0.0193). There was a trend toward worse local regional control and worse disease-free survival among patients with high bleomycin sensitivity. There was no difference between the two groups in distant metastasis-free survival or radiation treatment-related complications. CONCLUSIONS: High bleomycin sensitivity correlated with poor overall survival and disease-specific survival in these patients with stage III NSCLC treated with radiotherapy and chemotherapy. Bleomycin sensitivity may function as a biomarker for poor clinical outcome for this group of patients.
    Apr. 2005, Clinical cancer research : an official journal of the American Association for Cancer Research, 11(8) (8), 2894 - 8, English, International magazine
    [Refereed]
    Scientific journal

  • Ryohei Sasaki, Ritsuko Komaki, Homer Macapinlac, Jeremy Erasmus, Pamela Allen, Kenneth Forster, Joe B Putnam, Roy S Herbst, Cesar A Moran, Donald A Podoloff, Jack A Roth, James D Cox
    PURPOSE: To determine whether the standardized uptake value (SUV) of [(18)F]fluorodeoxyglucose uptake by positron emission tomography could be a prognostic factor for non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: One hundred sixty-two patients with stage I to IIIb NSCLC were analyzed. Overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and local-regional control (LRC) were calculated by the Kaplan-Meier method and evaluated with the log-rank test. The prognostic significance was assessed by univariate and multivariate analyses. RESULTS: There were 93 patients treated with surgery and 69 patients treated with radiotherapy. A cutoff of 5 for the SUV for the primary tumor showed the best discriminative value. The SUV for the primary tumor was a significant predictor of OS (P = .02) in both groups. Low SUVs ( 5.0; surgery group, P = .02; radiotherapy group, P = .0005). Low SUVs ( 5.0; stage I or II, P = .02; stage IIIa or IIIb, P = .004). However, using the same cutoff point of 5, the SUV for regional lymph nodes was not a significant indicator for DFS (P = .19), LRC (P = .97), or DMFS (P = .17). The multivariate analysis showed that the SUV for the primary tumor was a significant prognostic factor for OS (P = .03) and DFS (P = .001). CONCLUSION: The SUV of the primary tumor was the strongest prognostic factor among the patients treated by curative surgery or radiotherapy.
    Feb. 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 23(6) (6), 1136 - 43, English, International magazine
    [Refereed]
    Scientific journal

  • Combination of genistein with ionizing radiation on androgen-independent prostate cancer cells.
    Sen-Xiang Yan, Yasuo Ejima, Ryohei Sasaki, Shu-Sen Zheng, Yusuke Demizu, Toshinori Soejima, Kazuro Sugimura
    AIM: To study the effect of the combined use of genistein and ionizing radiation (IR) on prostate DU145 cancer cells. METHODS: DU145, an androgen-independent human prostate cancer cell line, was used in the experiment. Clonogenic assay was used to compare the survival of DU145 cells after treatments with genistein alone and in combination with graded IR. Apoptosis was assayed by DNA ladder and TUNEL stain. Cell cycle alterations were observed by flow cytometry and related protein expressions by immunoblotting. RESULTS: Clonogenic assay demonstrated that genistein, even at low to medium concentrations, enhanced the radiosensitivity of DU145 cells. Twenty-four hours after treatment with IR and/or genistein, apoptosis was mainly seen with genistein at high concentrations and was minimally related to IR. At 72 h, apoptosis also occurred in treatment with lower concentration of genistein, especially when combined with IR. While both IR and genistein led to G2/M cell cycle arrest, combination of them further increased the DU145 cells at G2/M phase. This G2/M arrest was largely maintained at 72 h, accompanied by increasing apoptosis and hyperdiploid cell population. Cell-cycle related protein analysis disclosed biphasic changes in cyclin B1 and less dramatically cdc-2, but stably elevated p21 cip1 levels with increasing genistein concentrations. CONCLUSION: Genistein enhanced the radiosensitivity of DU145 prostate cancer cells. The mechanisms might be involved in the increased apoptosis, prolonged cell cycle arrest and impaired damage repair.
    Dec. 2004, Asian journal of andrology, 6(4) (4), 285 - 90, English, International magazine
    [Refereed]
    Scientific journal

  • 放射線治療における全身倦怠感に関する検討
    Sasaki Ryohei
    Oct. 2004, 日本放射線腫瘍学会誌, 16巻, Suppl.1, pp. 181-181, Japanese
    International conference proceedings

  • 脳照射後5年以上生存例の二次腫瘍についての検討
    Sasaki Ryohei
    Oct. 2004, 日本放射線腫瘍学会誌, 16巻, Suppl.1, pp. 149-149, Japanese
    International conference proceedings

  • 炭素線・光子線併用照射の生物効果 亜致死損傷修復は影響するか?
    出水祐介, 古澤佳也, 青木瑞穂, 平山亮一, SASAKI, Ryohei, OKAMOTO, Yoshiaki, SOEJIMA,Toshinori, 安藤興一, SUGIMURA, Kazuro
    Oct. 2004, 日本放射線腫瘍学会誌, 16巻, Suppl.1, pp. 157-157, Japanese
    International conference proceedings

  • 眼付属器マルトリンパ腫と反応性リンパ球浸潤との境界病変
    江島泰生, SASAKI, Ryohei, OKAMOTO, Yoshiaki, 太田陽介, 出水祐介, SOEJIMA,Toshinori, SUGIMURA, Kazuro
    Oct. 2004, 日本放射線腫瘍学会誌, 16巻, Suppl.1, pp. 152-152, Japanese
    International conference proceedings

  • FDG-PETによるSUV(standardized uptake value)は非小細胞肺癌の結果を予測する(SUV by FDG-PET Predicts Outcome of Non-Small-Cell Lung Cancer)(英語)
    SASAKI, Ryohei, KomakiRitsuko, MacapinlacHomer, AllenPamela, PodoloffDonald, CoxJames D
    Oct. 2004, 日本放射線腫瘍学会誌, 16巻, Suppl.1, pp. 107-107, Japanese
    International conference proceedings

  • 分子医学の放射線治療への寄与 遺伝子治療と放射線治療
    SASAKI, Ryohei
    Sep. 2004, 日本医学放射線学会雑誌, 64巻, 6号, pp. S368-S369, Japanese
    International conference proceedings

  • Yusuke Demizu, Kazufumi Kagawa, Yasuo Ejima, Hideki Nishimura, Ryohei Sasaki, Toshinori Soejima, Toshihiro Yanou, Masakazu Shimizu, Yoshiya Furusawa, Yoshio Hishikawa, Kazuro Sugimura
    We investigated the biological effect of combining carbon-beam and X-ray in vitro. The results showed that when we employed Gray equivalent as the indication of therapeutic dose, the effects could be explained with simple additive way in the treatment plan. This fact provides important information about the combined therapy of carbon-beam and X-ray.
    May 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 71(2) (2), 207 - 11, English, International magazine
    [Refereed]
    Scientific journal

  • [Hypothyroidism after radiotherapy to the neck].
    Eisaku Yoden, Toshinori Soejima, Tsutomu Maruta, Yusuke Demizu, Hideki Nishimura, Yasuo Ejima, Ryohei Sasaki, Kazunari Yamada, Kazuro Sugimura
    PURPOSE: The purpose of this study was to investigate the incidence and possible predictors of hypothyroidism after radiotherapy to the neck, focusing on radiation dose-volume factors. METHODS AND MATERIALS: Thyroid function was measured in 169 patients treated with radiation ports including the thyroid, between 1989 and 2000. Hypothyroidism was determined with an endpoint of elevated serum thyroid stimulating hormone(TSH) levels > 10.0 microU/ml. In 60 patients, radiation dose-volume factors were calculated; e.g., total volume of the thyroid, mean radiation dose to the thyroid, and %-volume of the thyroid which received radiation doses of no less than 10-70 Gy(V10-V70). The evaluated risk factors for hypothyroidism included these dose-volume factors, sex, age, primary disease, combined chemotherapy, and follow-up period. RESULTS: Hypothyroidism was detected in 33 (19.5%) of the 169 patients. None of them had clinical symptoms of hypothyroidism. V10, V20, and V30 seemed to be possible predictors of hypothyroidism and had a significant impact on the peak level of serum TSH. CONCLUSION: Radiation dose-volume factors of the thyroid seemed to correlate with the incidence of hypothyroidism, and V10, V20, and V30 had a significant impact on the peak level of serum TSH.
    Mar. 2004, Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 64(3) (3), 146 - 50, Japanese, Domestic magazine
    [Refereed]
    Scientific journal

  • 頸部放射線治療後の甲状腺機能低下 線量体積因子を用いた試験的解析
    YODEN,Eisaku, SOEJIMA,Toshinori, 丸田力, 出水祐介, NISHIMURA, Hideki, 江島泰生, SASAKI, Ryohei, YAMADA,Kazunari, SUGIMURA, Kazuro
    Mar. 2004, 日本医学放射線学会雑誌, 64巻, 3号, pp. 146-150, Japanese
    [Refereed]
    Scientific journal

  • 炭素線とX線のmixed beam irradiationの有用性に関する基礎実験
    出水祐介, 江島泰生, NISHIMURA, Hideki, SASAKI, Ryohei, SOEJIMA,Toshinori, SUGIMURA, Kazuro, 香川一史, 菱川良夫, 古澤佳也
    Mar. 2004, 日本医学放射線学会雑誌, 64巻, 3号, pp. 162-162, Japanese
    International conference proceedings

  • YL Jiang, MFT Escano, R Sasaki, S Fujii, S Kusuhara, A Matsumoto, K Sugimura, A Negi
    Mar. 2004, JAPANESE JOURNAL OF OPHTHALMOLOGY, 48(2) (2), 106 - 114, English
    [Refereed]
    Scientific journal

  • Mutagen sensitivity predicts poor overall and disease specific survival in patients with stage III non-small cell lung cancer treated with chemo/radiotherapy
    LY Chang, Wu, X, R Komaki, R Sasaki, P Allen, Z Liao, CW Stevens, C Lu, FV Fossella, JD Cox, MR Spitz
    2004, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 60(1) (1), S237 - S238, English
    [Refereed]
    Scientific journal

  • Outcome of ocular adnexal MALT lymphoma treated with radiotherapy
    Y Ejima, Y Okamoto, R Sasaki, Y Demizu, Y Ota, T Soejima, K Sugimura
    2004, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 60(1) (1), S546 - S546, English
    [Refereed]
    Scientific journal

  • Cell biological basis for combination radiotherapy using carbon-beam and photon
    Y Demizu, Y Furusawa, M Aoki, R Hirayama, Y Ejima, Y Ota, R Sasaki, Y Okamoto, T Soejima, K Ando, K Sugimura
    2004, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 60(1) (1), S358 - S359, English
    [Refereed]
    Scientific journal

  • Biological assessment of mixed beam irradiation of carbon-ion and X-ray
    Demizu Y, Kagawa K, Ejima Y, NISHIMURA, Hideki, SASAKI, Ryohei, Soejima T, SUGIMURA, Kazuro, Hishikawa Y, Furusawa Y
    2004, European Journal Of Cancer, Vol. 1, No. 5, pp. s145-s146, English
    [Refereed]
    Scientific journal

  • 炭素線とX線のmixed beam irradiation 生物効果の検討
    出水祐介, 香川一史, 江島泰生, NISHIMURA, Hideki, SASAKI, Ryohei, SOEJIMA,Toshinori, 古澤佳也, 菱川良夫, SUGIMURA, Kazuro
    Oct. 2003, 日本放射線腫瘍学会誌, 15巻, Suppl.1, pp. 130-130, Japanese
    International conference proceedings

  • SUV by FDG-PET predicts outcome of non-small cell lung cancer
    SASAKI, Ryohei, Komaki R, Macapinlac H, Erasmus J, Allen P, Forster K, Roth J, Putnam JB, Moran C, Cox JD
    Oct. 2003, International Journal Of Radiation Oncology, Biology, Physics, Vol. 57, No. 2 Suppl, pp. S166, English
    [Refereed]
    Scientific journal

  • Combination of genistein with ionizing radiation on surviving fraction, apoptosis and cell-cycle alterations on Du-145 prostate cancer cells
    Ejima Y, Yan S, SASAKI, Ryohei, NISHIMURA, Hideki, Demizu Y, OKAMOTO, Yoshiaki, MATSUMOTO,Akira, Soejima T, SUGIMURA, Kazuro
    Oct. 2003, International Journal Of Radiation Oncology, Biology, Physics, Vol. 57, No. 2 Suppl, pp. S353, English
    [Refereed]
    Scientific journal

  • Expression of granzyme B in human articular chondrocytes
    K Horiuchi, S Saito, R Sasaki, T Tomatsu, Y Toyama
    Aug. 2003, JOURNAL OF RHEUMATOLOGY, 30(8) (8), 1799 - 1810, English
    [Refereed]
    Scientific journal

  • Platelet-derived growth Factor-BB generate neural stem cells from proliferating retinal astrocytes
    S Fujii, MFT Escano, S Kusuhara, Y Tamura, R Sasaki, A Negi
    May 2003, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 44, U395 - U395, English
    [Refereed]
    International conference proceedings

  • P53-mediated apoptosis in human RPE cells after low-dose radiation
    Y Jiang, MFT Escano, S Kusuhara, S Fujii, R Sasaki, A Negi
    May 2003, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 44, U548 - U548, English
    [Refereed]
    International conference proceedings

  • 中咽頭側壁型扁平上皮癌症例の検討
    SASAKI RYOHEI
    Jan. 2003, 日本耳鼻咽喉科学会会報, 106巻, 1増刊, pp. 99-99, Japanese
    International conference proceedings

  • Radiotherapy for medically inoperable non-small cell lung cancer at clinical stage I and II
    K Yamada, T Soejima, Y Ota, R Sasaki, E Yoden, N Kanaoka, T Maruta, K Sugimura
    Jan. 2003, TUMORI, 89(1) (1), 75 - 79, English, International magazine
    [Refereed]
    Scientific journal

  • Tetsuya Kawabe, Ryohei Sasaki, Hideki Nishimura, Toshinori Soejima, Shogo Matsuyama, Kazuro Sugimura, Akira Matusumoto
    Sep. 2002, Neuroscience Research Communications, 31(2) (2), 75 - 84, English
    [Refereed]
    Scientific journal

  • Hepatopancreatoduodenectomy with wide lymph node dissection for locally advanced carcinoma of the gallbladder - Long-term results
    R Sasaki, M Takahashi, O Funato, H Nitta, M Murakami, H Kawamura, T Suto, S Kanno, K Saito
    Jul. 2002, HEPATO-GASTROENTEROLOGY, 49(46) (46), 912 - 915, English
    [Refereed]
    Scientific journal

  • Angiosarcoma treated with radiotherapy: impact of tumor type and size on outcome.
    Ryohei Sasaki, Toshinori Soejima, Kazushi Kishi, Yoshinari Imajo, Saeko Hirota, Norihiko Kamikonya, Masao Murakami, Tetsuya Kawabe, Yasuo Ejima, Akira Matsumoto, Kazuo Sugimura
    PURPOSE: Angiosarcoma is a rare and highly malignant vascular neoplasm. The purpose of this study was to elucidate the tumor characteristics and evaluate the efficacy of radiotherapy (RT) for angiosarcoma. MATERIALS AND METHODS: Thirty patients with angiosarcoma (20 males and 10 females, age range 4-89 years, median 66) who received RT from 1986 to 1999 were enrolled in the study. Twenty-four patients had angiosarcoma of the face and scalp (AFS), and 6 patients had angiosarcomas at other sites. AFS was classified into two categories (according to the macroscopic features): nodular AFS (14 patients) and endophytic AFS (10 patients). The median prescribed irradiation dose was 68 Gy. Surgery had been previously performed in 9 patients, and adjuvant immunotherapy using recombinant interleukin-2 (rIL-2) was combined during and after RT in 20 patients. Univariate analyses and calculation of survival by Kaplan-Meier methods were performed. RESULTS: Local tumor control was obtained in 17 patients (57%). However, 7 (47%) of them developed distant metastases. The median survival time for all patients was 8 months (7 months for AFS), and the 13-year overall survival rate was 25% (20% for AFS). Twenty-one patients died of angiosarcoma, with the cause of death local failure in 7 patients, distant failure in 7, and both in 7. Tumor type and size were found to be significant prognostic factors (p = 0.004 and p = 0.007, respectively), and age, total amount of rIL-2, gender, radiation dose, and surgery were not. Six patients (4 with nodular AFS and 2 with angiosarcoma in other parts) survived >2 years. No patient with endophytic AFS survived >2 years. Ten patients (33%) died of respiratory failure secondary to pulmonary metastases. High-dose rIL-2 administration suppressed the occurrence of distant metastases (p = 0.006). Two patients developed radiation dermatitis (Radiation Therapy Oncology Group Grade 4). CONCLUSION: RT, combined with complete resection or adjuvant rIL-2 immunotherapy, could be a promising treatment strategy, leading to prolonged survival in patients with angiosarcoma.
    Mar. 2002, International journal of radiation oncology, biology, physics, 52(4) (4), 1032 - 40, English, International magazine
    [Refereed]
    Scientific journal

  • Reirradiation for locally recurrent lung cancer previously treated with radiation therapy.
    Yoshiaki Okamoto, Masao Murakami, Eisaku Yoden, Ryohei Sasaki, Yoshishige Okuno, Toshifumi Nakajima, Yasumasa Kuroda
    PURPOSE: Local recurrence of lung cancer after previous external beam irradiation poses some problems for subsequent management. We retrospectively reviewed our series of patients with local recurrence of lung cancer to evaluate the efficacy and safety of reirradiation. PATIENTS AND METHODS: Between 1979 and 2000, 34 patients with local recurrence of lung cancer were retreated with external radiation. There were 29 males and 5 females ranging in age from 38 to 85 years (median: 69 years). At the time of reirradiation, the clinical stage was I or II in 2 patients, IIIa in 5 patients, IIIb in 14 patients, and IV in 13 patients. Reirradiation was performed in 18 patients with the aim of achieving a cure or prolongation of survival (radical treatment), while 16 patients were treated for improvement of their symptoms (symptomatic treatment). RESULTS: The median interval between the initial radiation therapy and reirradiation was 23 months, with a range of 5 to 87 months. The dose of initial irradiation delivered to the tumor ranged from 30 to 80 Gy (median: 60 Gy) in 1.5--2.0-Gy fractions per day. During reirradiation, it ranged from 10 to 70 Gy (median: 50 Gy) in 1.8--3.0-Gy fractions per day. The cumulative dose delivered to the tumor by treatments of both initial and second irradiation ranged from 56.5 to 150 Gy (median: 110 Gy). A response was observed in 14 out of 18 patients given radical treatment (complete response, 6; partial response, 8). Twelve of the 16 patients (75%) given symptomatic treatment also showed a symptomatic benefit. The overall survival rate after reirradiation was 43% at 1 year and 27% at 2 years, with a median survival time of 8 months. The median survival time after radical treatment was 15 months, with a range of 3 to 58 months, whereas that after symptomatic treatment was 3 months, with a range of 1 to 14 months. Six long-term survivors lived for more than 20 months. Reirradiation-induced toxicity included symptomatic radiation pneumonitis in 19 patients and symptomatic radiation esophagitis in 6 patients. These toxicities were not fatal, and radiation myelopathy was not caused by reirradiation. CONCLUSION: Based on this study, external beam reirradiation can achieve satisfactory results for local recurrence of lung cancer provided that attention is paid to the possible hazards.
    Feb. 2002, International journal of radiation oncology, biology, physics, 52(2) (2), 390 - 6, English, International magazine
    [Refereed]
    Scientific journal

  • Case of radiation-induced esophageal ulcer worsened after endoscopic biopsy
    T Soejima, H Nishimura, Y Ejima, R Sasaki, E Yoden, K Yamada, K Sugimura
    2002, DISEASES OF THE ESOPHAGUS, 15(3) (3), 266 - 268, English
    [Refereed]
    Scientific journal

  • Additional gene therapy with Ad5CMV-p53 enhanced the efficacy of radiotherapy in human prostate cancer cells
    R Sasaki, T Shirakawa, ZJ Zhang, A Tamekane, A Matsumoto, K Sugimura, M Matsuo, S Kamidono, A Gotoh
    Dec. 2001, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 51(5) (5), 1336 - 1345, English
    [Refereed]
    Scientific journal

  • T Shirakawa, R Sasaki, TA Gardner, CH Kao, ZJ Zhang, K Sugimura, M Matsuo, S Kamidono, A Gotoh
    Oct. 2001, INTERNATIONAL JOURNAL OF CANCER, 94(2) (2), 282 - 289, English
    [Refereed]
    Scientific journal

  • Clinical significance of serum pulmonary surfactant proteins A and D for the early detection of radiation pneumonitis
    R Sasaki, T Soejima, A Matsumoto, T Maruta, K Yamada, Y Ota, T Kawabe, H Nishimura, E Sakai, Y Ejima, K Sugimura
    Jun. 2001, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 50(2) (2), 301 - 307, English
    [Refereed]
    Scientific journal

  • Pilot study of local radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma
    K Yamada, T Soejima, K Sugimoto, H Mayahara, K Izaki, R Sasaki, T Maruta, S Matsumoto, S Hirota, K Sugimura
    Apr. 2001, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 31(4) (4), 147 - 152, English
    [Refereed]
    Scientific journal

  • R. Sasaki, H. Nishimura, T. Soejima, Y. Ejima, E. Yoden, T. Shirakawa, A. Gotoh, Y. Ota, A. Matsumoto, K. Sugimura
    2001, International Journal of Radiation Oncology Biology Physics, 51, 56 - 57, English
    [Refereed]
    Scientific journal

  • Akira Matsumoto, Kenjiro Motozaki, Tsuneyoshi Seki, Ryohei Sasaki, Tetsuya Kawabe
    2001, Neuroscience Research, 39(3) (3), 313 - 317, English
    [Refereed]
    Scientific journal

  • Prenatal ionizing radiation-induced apoptosis of the developing murine brain with special references to the expression of some proteins
    Makiko Kitamura, Kyoko Itoh, Akira Matsumoto, Yoshitake Hayashi, Ryohei Sasaki, Yukihiro Imai, Hiroshi Itoh
    2001, Kobe Journal of Medical Sciences, 47(2) (2), 59 - 76, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • The efficacy of conventional radiation therapy in the management of pituitary adenoma
    R Sasaki, M Murakami, Y Okamoto, K Kono, E Yoden, T Nakajima, S Nabeshima, Y Kuroda
    Jul. 2000, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 47(5) (5), 1337 - 1345, English
    [Refereed]
    Scientific journal

  • Ryohei Sasaki, Akira Matsumoto, Kyoko Itoh, Tetsuya Kawabe, Yosuke Ota, Kazunari Yamada, Tsutomu Maruta, Toshinori Soejima, Kazuro Sugimura
    Jan. 2000, Neuroscience Letters, 279(1) (1), 57 - 60, English
    [Refereed]
    Scientific journal

  • Radiation Therapy for Non-Small Cell Lung Cancer with Postoperative Intrathoracic Recurrence
    Koichi Kono, Masao Murakami, Ryohei Sasaki, Yoshiaki Okamoto, Eisaku Yodenn, Katsuhiro Kobayashi, Takeshi Kubo, Heitetsu Sai, Yoji Maetani, Yasumasa Kuroda
    1998, Nippon Acta Radiologica, 58(1) (1), 18 - 24, Japanese
    [Refereed]
    Scientific journal

  • MURAKAMI Masao, KURODA Yasumasa, SATO Koichi, SASAKI Ryohei, YODEN Eisaku, KONO Koichi, OKAMOTO Yoshiaki
    For quality assurance of clinical radiation oncology, we configured a medical record system connected via a local area network (LAN) within our Radiation Oncology Division. The system includes basic patient information, evaluated stage of disease, therapeutic methods, d esigned to irradiation treatment data, and radiation effects of tumor as well as injuries. This system is designed to assist radiation oncology operations in realtime, not only during irradiationb ut also during follow-up periods.
    (Methord) 1) Hardware: six personal computer clients were set up in the reception office, d octor's room, consulting room, and technologist's operation room and connected to one another via Ethernet. 2) Software: MS-DOS Ver.6.2, NETWARE Ver.3.12J, R: BASE Ver.4.5 were used. 3) I nput Items: Data input is done by the individual persons concerned. There are 226 basici nformation items on external irradiation and brachytherapy, 79 (35%) of which are actually inputd octors, 39 (17%) by technicians, 26 (12%) by clerks, and 7 (3%) by nurses. The remaining 75 (33%) are calculated automatically. TNM-Stage and International Classification of Diseases for Oncology code can be selected from menu items on a CRT window. There database structures conform to ROGAD (Radiation Onchology Greater Area Database) proposed by JASTRO (The Japanese Society for Therapeutic Radiology and Oncology). 4) Output: Daily patient reports with radiation records, and summarized therapy information to the clinicians are facilitated.
    (Results) The initial benefits included: i) mutual understanding among staff, ii) machine-written radiation exposure data with resister card, iii) accurate communication, iv) improved medical description system through standardization of items, v) educational benefits for newcomers, vi) realtime correspondence to clinical needs, and vii) realtime access and reference to stored data.
    (Conclusion) Having input patents' data over the past 29 years, we believe that this system will contribute more to clinical radiation onchology in the future.
    Japanese Society for Therapeutic Radiology and Oncology, 1996, J Jpn Soc Ther Radiol Oncol, 8(4) (4), 317 - 328, Japanese

■ MISC
  • Share Space-Making Particle Therapy with Surgical Spacer Placement
    大片祐一, 大片祐一, 小松昇平, 尾藤祐子, 佐々木良平, 福本巧
    2022, 日本小児血液・がん学会雑誌(Web), 59(4) (4)

  • Space-making proton therapy using bioabsorbable spacer for a pediatric case with Ewing sarcoma: Upfront boost irradiation
    出水祐介, 美馬正幸, 福光延吉, 鈴木毅, 畠山理, 小阪嘉之, 福本巧, 佐々木良平, 副島俊典
    2021, 日本小児血液・がん学会雑誌(Web), 58(4) (4)

  • T3N0M0声門癌に対する根治的放射線治療の成績
    岩下和真, 石原武明, 妹尾悟史, 窪田光, 川口弘毅, 小林加奈, 宮脇大輔, 佐々木良平, 蓼原瞬, 手島直則, 四宮弘隆, 丹生健一, 今村善宣, 清田尚臣
    2021, 頭頸部癌, 47(2) (2)

  • 再発・転移頭頸部扁平上皮癌に対するニボルマブ療法治療の予後予測における好酸球数変化の有用性
    小山泰司, 清田尚臣, 清田尚臣, 今村善宣, 長谷善明, 蓼原瞬, 手島直則, 四宮弘隆, 宮脇大輔, 佐々木良平, 丹生健一
    2021, 頭頸部癌, 47(2) (2)

  • Oncogenic miRNAs Identified in Tear Exosomes From Metastatic Breast Cancer Patients (vol 40, pg 3091, 2020)
    Sachiko Inubushi, Hiroki Kawaguchi, Sachiko Mizumoto, Tomonari Kunihisa, Motoi Baba, Yukiya Kitayama, Toshifumi Takeuchi, Robert M. Hoffman, Hirokazu Tanino, Ryohei Sasaki
    Aug. 2020, ANTICANCER RESEARCH, 40(8) (8), 4805 - 4805, English
    Others

  • Shohei Komatsu, Yusuke Demizu, Nor Shazrina Sulaiman, Kazuki Terashima, Masaki Suga, Masahiro Kido, Hirochika Toyama, Sunao Tokumaru, Tomoaki Okimoto, Ryohei Sasaki, Takumi Fukumoto
    BACKGROUND: The primary definitive treatment for abdominopelvic sarcomas (APSs) is resection, although incomplete resection has a negative prognostic impact. Although the effectiveness of particle therapy (PT) as a treatment for APS has already been demonstrated, its application for tumors adjacent to the gastrointestinal tract is frequently restricted, due to extremely low tolerance. Space-making PT, consisting of surgical spacer placement and subsequent PT, has been developed to overcome this limitation. MATERIALS AND METHODS: Between June 2006 and June 2018, a total of 75 patients with 12 types of APS underwent space-making PT. RESULTS: The 3-year local control rate of all patients was 90.3%. Fourteen surgery-related complications were observed in 12 patients (16%), and complications of Grade 3b or higher were observed in 3 patients. Ninety-five PT-related complications were seen in 66 patients (88.0%), and 13 patients (17.3%) had complications of Grade 3 or higher. The median V95% (volume irradiated with 95% of the treatment planning dose) of the gross tumor volume and clinical target volume were 99.9% and 99.5%, respectively. The median D95% (dose intensity covering 95% of the target volume) of the gross tumor volume/planned dose and clinical target volume/planned dose were 99.4%, and 99.1%, respectively. CONCLUSION: The feasibility and effectiveness of space-making PT have been demonstrated via dosimetric evaluation, and our results indicate that this new strategy may potentially provide an effective and innovative treatment option for advanced APS.
    25 Mar. 2020, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 146, 194 - 199, English, International magazine

  • Daisuke Tsugawa, Shohei Komatsu, Yusuke Demizu, Nor Shazrina Sulaiman, Masaki Suga, Masahiro Kido, Hirochika Toyama, Tomoaki Okimoto, Ryohei Sasaki, Takumi Fukumoto
    BACKGROUND: Sacral chordomas are rare malignant bone tumors and are often very large for complete resection. Particle therapy for these tumors, which are adjacent to the gastrointestinal tract, is restricted because the tolerance dose of the intestine is low. This study aimed to demonstrate the technical aspects and treatment results of space-making particle therapy with surgical spacer placement for sacral chordoma. We aimed to investigate the dosimetric change in the particle therapy before and after spacer placement and the safety, efficacy, and long-term outcomes of space-making particle therapy. STUDY DESIGN: Twenty-one patients with sacral chordomas who were excluded from typical particle therapy were enrolled between 2007 and 2015. Gore-Tex sheets (WL Gore & Assoc) were folded and placed between the sacral and rectum. Particle therapy with 70.4 Gy (relative biologic effectiveness) was then performed. RESULTS: The mean volume that allows 95% of the treatment plan dose of the gross tumor volume and clinical tumor volume after spacer placement was improved to 97.7% and 96.4% from preoperative values of 91.0% and 89.5%, respectively. The recurrence rate within the gross tumor volume was only 4.8%. The 4-year local progression-free survival rate was 68.4%. The 5-year overall survival rate was 100% and the adverse events were acceptable. CONCLUSIONS: Considering improvements in the dose-volume histogram after spacer placement, low recurrence rates within the gross tumor volume, good survival rates, and low incidences of side effects, treatment of sacral chordoma with space-making particle therapy shows promise.
    23 Nov. 2019, Journal of the American College of Surgeons, 230(2) (2), 207 - 215, English, International magazine

  • 放射線治療 QOLを考慮した局所治療 小児がんに対する吸収性スペーサー留置を併用した粒子線治療
    佐々木 良平, 出水 祐介, 岩田 宏満, 亀井 美智, 文野 誠久, 赤坂 浩亮, 王 天縁, 妹尾 悟史, 犬伏 祥子, 宮脇 大輔, 吉田 賢史, 小松 昇平, 福本 巧
    (一社)日本小児血液・がん学会, Sep. 2019, 日本小児血液・がん学会雑誌, 56(2) (2), 148 - 152, Japanese

  • 金ナノ粒子内包分子インプリントポリマーナノゲルによる放射線治療
    北山 雄己哉, 木口 健太朗, 山田 託也, 吉田 碧衣, 赤坂 浩亮, 西村 勇哉, 五十嵐 一紀, 松本 有, 佐々木 良平, 竹内 俊文
    日本DDS学会, Jun. 2019, 日本DDS学会学術集会プログラム予稿集, 35回, 152 - 152, Japanese

  • 再発転移頭頸部扁平上皮癌 ニボルマブ投与例におけるmodified Glasgow Prognostic Scoreの予後予測性
    今村 善宣, 清田 尚臣, 金原 史朗, 小山 泰司, 大月 直樹, 四宮 弘隆, 蓼原 瞬, 入谷 啓介, 宮脇 大輔, 南川 勉, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 132 - 132, Japanese

  • 下咽頭癌外側咽頭後リンパ節転移症例の検討
    手島 直則, 古川 竜也, 森田 成彦, 四宮 弘隆, 森本 浩一, 大月 直樹, 清田 尚臣, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 149 - 149, Japanese

  • 再発転移鼻副鼻腔原発粘膜悪性黒色腫に対するニボルマブの後方視的検討
    小山 泰司, 清田 尚臣, 金原 史朗, 今村 善宣, 蓼原 瞬, 入谷 啓介, 四宮 弘隆, 大月 直樹, 南川 勉, 宮脇 大輔, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 162 - 162, Japanese

  • 頭頸部扁平上皮癌術後の再発高リスク症例に対する放射線療法の治療成績の検討
    妹尾 悟史, 吉田 賢史, 宮脇 大輔, 石原 武明, 今村 善宣, 清田 尚臣, 四宮 弘隆, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 168 - 168, Japanese

  • 中咽頭癌に対する化学放射線療法による摂食・嚥下に関するQOLの変化
    高橋 美貴, 岩城 忍, 涌井 絵美, 古川 竜也, 四宮 弘隆, 大月 直樹, 清田 尚臣, 宮脇 大輔, 佐々木 良平, 喜多川 浩一, 西村 英輝, 丹生 健一
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 169 - 169, Japanese

  • 頭頸部発生したグロームス腫瘍に対する放射線治療成績
    佐々木 良平, 宮脇 大輔, 吉田 賢史, 石原 武明, 井上 由子, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 174 - 174, Japanese

  • T4下咽頭癌に対する根治的(化学)放射線療法の後方視的検討
    宮脇 大輔, 石原 武明, 吉田 賢史, 今村 善宣, 四宮 弘隆, 清田 尚臣, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 201 - 201, Japanese

  • 肝細胞癌に対する放射線照射治療後の経動脈的化学塞栓療法の安全性の検討
    小出 裕, ムスタファ・ハマダ, 上嶋 英介, 堀之内 宏樹, 佐々木 康二, 元津 倫幸, 谷 龍一郎, 岡田 卓也, 祖父江 慶太郎, 山口 雅人, 石田 淳, 石原 武明, 佐々木 良平, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 226 - 226, Japanese

  • 再発転移頭頸部扁平上皮癌 ニボルマブ投与例におけるmodified Glasgow Prognostic Scoreの予後予測性
    今村 善宣, 清田 尚臣, 金原 史朗, 小山 泰司, 大月 直樹, 四宮 弘隆, 蓼原 瞬, 入谷 啓介, 宮脇 大輔, 南川 勉, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 132 - 132, Japanese

  • 下咽頭癌外側咽頭後リンパ節転移症例の検討
    手島 直則, 古川 竜也, 森田 成彦, 四宮 弘隆, 森本 浩一, 大月 直樹, 清田 尚臣, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 149 - 149, Japanese

  • 再発転移鼻副鼻腔原発粘膜悪性黒色腫に対するニボルマブの後方視的検討
    小山 泰司, 清田 尚臣, 金原 史朗, 今村 善宣, 蓼原 瞬, 入谷 啓介, 四宮 弘隆, 大月 直樹, 南川 勉, 宮脇 大輔, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 162 - 162, Japanese

  • 頭頸部扁平上皮癌術後の再発高リスク症例に対する放射線療法の治療成績の検討
    妹尾 悟史, 吉田 賢史, 宮脇 大輔, 石原 武明, 今村 善宣, 清田 尚臣, 四宮 弘隆, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 168 - 168, Japanese

  • 中咽頭癌に対する化学放射線療法による摂食・嚥下に関するQOLの変化
    高橋 美貴, 岩城 忍, 涌井 絵美, 古川 竜也, 四宮 弘隆, 大月 直樹, 清田 尚臣, 宮脇 大輔, 佐々木 良平, 喜多川 浩一, 西村 英輝, 丹生 健一
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 169 - 169, Japanese

  • 頭頸部発生したグロームス腫瘍に対する放射線治療成績
    佐々木 良平, 宮脇 大輔, 吉田 賢史, 石原 武明, 井上 由子, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 174 - 174, Japanese

  • T4下咽頭癌に対する根治的(化学)放射線療法の後方視的検討
    宮脇 大輔, 石原 武明, 吉田 賢史, 今村 善宣, 四宮 弘隆, 清田 尚臣, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 201 - 201, Japanese

  • 頭頸部癌に対する放射線治療後の放射線性顎骨壊死に関する検討
    窪田 光, 宮脇 大輔, 佐々木 香織, 妹尾 悟史, 井上 由子, 川口 弘毅, 西川 遼, 石原 武明, 吉田 賢史, 岸本 恵美, 明石 昌也, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 244 - 244, Japanese

  • 脊椎転移に対する手術療法の効果と限界
    角谷 賢一朗, 酒井 良忠, 由留部 崇, 高田 徹, 張 鍾頴, 宮崎 真吾, 垣内 裕司, 武岡 由樹, 神田 祐太郎, 辻本 龍, 河本 旭哉, 原 仁美, 深瀬 直政, 岡田 卓也, 坂下 明大, 佐々木 良平, 秋末 敏宏, 黒田 良祐, 西田 康太郎
    (一社)日本脊椎脊髄病学会, May 2019, Journal of Spine Research, 10(5) (5), 898 - 904, Japanese

  • 肝細胞癌に対する放射線照射治療後の経動脈的化学塞栓療法の安全性の検討
    小出 裕, ムスタファ・ハマダ, 上嶋 英介, 堀之内 宏樹, 佐々木 康二, 元津 倫幸, 谷 龍一郎, 岡田 卓也, 祖父江 慶太郎, 山口 雅人, 石田 淳, 石原 武明, 佐々木 良平, 杉本 幸司, 村上 卓道
    (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 226 - 226, Japanese

  • 肺癌術後局所領域再発に対する根治的放射線治療の治療成績の検討
    河野 泰秀, 松尾 圭朗, 吉田 賢史, 川口 弘毅, 西川 遼, 石原 武明, 宮脇 大輔, 江島 泰生, 佐々木 良平, 西村 善博
    (公社)日本医学放射線学会, Feb. 2019, Japanese Journal of Radiology, 37(Suppl.) (Suppl.), 34 - 34, Japanese

  • 巨大腫瘤を呈した進行外陰癌3例に対する放射線治療の経験
    井上 由子, 吉田 賢史, 宮脇 大輔, 上薗 玄, 石原 武明, 西川 遼, 妹尾 悟史, 佐々木 良平, 蝦名 康彦
    (公社)日本医学放射線学会, Feb. 2019, Japanese Journal of Radiology, 37(Suppl.) (Suppl.), 43 - 43, Japanese

  • 神経線維腫症1型(NF1)に生じた悪性末梢神経鞘腫に対する放射線治療経験
    松田 耕平, 宮脇 大輔, 吉田 賢史, 石原 武明, 西川 遼, 井上 由子, 妹尾 悟史, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2019, Japanese Journal of Radiology, 37(Suppl.) (Suppl.), 43 - 43, Japanese

  • 小児がんに対する吸収性スペーサー留置を併用した粒子線治療
    佐々木良平, 出水祐介, 岩田宏満, 亀井美智, 文野誠久, 赤坂浩亮, 王天縁, 妹尾悟史, 犬伏祥子, 宮脇大輔, 吉田賢史, 小松昇平, 福本巧
    2019, 日本小児血液・がん学会雑誌(Web), 56(2) (2)

  • インタクトエクソソームによる乳がん高速検知のための抗体融合分子インプリントセンシングチップ
    竹内俊文, 森貴翔, 清水拓, 広瀬柚月, 高野恵里, 砂山博文, 北山雄己哉, 犬伏祥子, 佐々木良平, 谷野裕一
    2019, 応用物理学会秋季学術講演会講演予稿集(CD-ROM), 80th

  • 多職種協働で行うがんサバイバーへの癒しをテーマに開催したイベントの実践報告と今後の課題
    川邊 有希, 大田 史江, 山中 真美, 田中 幸江, 大橋 裕久子, 濱島 健児, 宮脇 大輔, 佐々木 良平
    (一社)日本がん看護学会, Jan. 2019, 日本がん看護学会誌, 33(Suppl.) (Suppl.), 271 - 271, Japanese

  • Pediatrician Perspectives on Radiation Therapy in Pediatric Tumor Treatment
    Michi Kamei, Hiromitsu Iwata, Risa Takeda, Satoru Yoshida, Taro Mural, Daisuke Takagi, Satoshi Kondo, Hiroyuki Ogino, Ryohei Sasaki, Shinji Saitoh
    Nov. 2018, PEDIATRIC BLOOD & CANCER, 65, S10 - S11, English
    Summary international conference

  • 放射線治療のための金ナノ粒子内包分子インプリントポリマーナノゲルの開発
    北山 雄己哉, 山田 託也, 木口 健太朗, 吉田 碧衣, 赤坂 浩亮, 西村 勇哉, 五十嵐 一紀, 松本 有, 佐々木 良平, 竹内 俊文
    日本バイオマテリアル学会, Nov. 2018, 日本バイオマテリアル学会大会予稿集, 40回, 146 - 146, Japanese

  • 放射線治療:QOLを考慮した局所治療 小児がんに対する吸収性スペーサーの開発
    佐々木 良平, 岩田 宏満, 亀井 美智, 出水 祐介, 文野 誠久, 中尾 朋平, 淡河 恵津世, 王 天縁, 妹尾 悟史, 犬伏 祥子
    (一社)日本小児血液・がん学会, Oct. 2018, 日本小児血液・がん学会雑誌, 55(4) (4), 169 - 169, Japanese

  • 非小細胞肺癌の転移性脳腫瘍に対する定位照射に関する検討
    川口 弘毅, 馬屋原 博, 石原 武明, 佐々木 良平
    (NPO)日本肺癌学会, Oct. 2018, 肺癌, 58(6) (6), 567 - 567, Japanese

  • 甲状腺がんに対するレンバチニブ治療中の観血的処置の安全性に関する遡及的検討
    金原 史朗, 清田 尚臣, 今村 善宣, 大月 直樹, 丹生 健一, 南川 勉, 原 仁美, 角谷 賢一朗, 佐々木 良平, 南 博信
    日本内分泌外科学会・日本甲状腺外科学会, Oct. 2018, 日本内分泌・甲状腺外科学会雑誌, 35(Suppl.2) (Suppl.2), S319 - S319, Japanese

  • 腹部悪性腫瘍に対する粒子線治療適応拡大を可能とする新規素材吸収性スペーサーの開発と臨床応用
    小松 昇平, 木戸 正浩, 田中 基文, 外山 博近, 上野 公彦, 味木 徹夫, 出水 祐介, 沖本 智昭, 佐々木 良平, 福本 巧
    (一社)日本消化器外科学会, Jul. 2018, 日本消化器外科学会総会, 73回, 806 - 806, Japanese

  • 亀井 美智, 岩田 宏満, 増本 幸二, 中尾 朋平, 新開 統子, 福島 敬, 櫻井 英幸, 高木 大輔, 近藤 知史, 文野 誠久, 出水 祐介, 石田 裕二, 田尻 達郎, 淡河 恵津世, 副島 俊典, 佐々木 良平
    (NPO)日本小児外科学会, May 2018, 日本小児外科学会雑誌, 54(3) (3), 578 - 578, Japanese

  • 甲状腺癌気道浸潤例に対する放射線外照射の有効性の検討
    鈴木 千晶, 清田 尚臣, 大月 直樹, 宮脇 大輔, 今村 善宣, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2018, 頭頸部癌, 44(2) (2), 176 - 176, Japanese

  • In situステルス性獲得にもとづく長期血中滞留性金ナノ粒子内包分子インプリントナノゲルの創製
    北山 雄己哉, 山田 託也, 赤坂 浩亮, 西村 勇哉, 五十嵐 一紀, 松本 有, 佐々木 良平, 竹内 俊文
    日本DDS学会, May 2018, 日本DDS学会学術集会プログラム予稿集, 34回, 173 - 173, Japanese

  • 過酸化チタンナノ粒子の併用による放射線増感治療法の開発
    西村 勇哉, 森田 健太, 荻野 千秋, 犬伏 祥子, 佐々木 良平, 近藤 昭彦
    日本DDS学会, May 2018, 日本DDS学会学術集会プログラム予稿集, 34回, 204 - 204, Japanese

  • 粒子線治療適応拡大を可能とするスペーサー手術の現状と展望
    小松 昇平, 木戸 正浩, 田中 基文, 外山 博近, 上野 公彦, 味木 徹夫, 出水 祐介, 沖本 智昭, 佐々木 良平, 福本 巧
    (一社)日本外科学会, Apr. 2018, 日本外科学会定期学術集会抄録集, 118回, 1019 - 1019, Japanese

  • 肝細胞癌に対するサイバーナイフによる定位放射線治療の初期経験
    橋本 直樹, 西村 英輝, 馬屋原 博, 上薗 玄, 原田 文, 中村 匡希, 尾方 俊至, 中山 雅央, 松尾 圭朗, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2018, Japanese Journal of Radiology, 36(Suppl.) (Suppl.), 25 - 25, Japanese

  • JASTRO放射線治療症例全国登録(JROD)の取り組み
    沼崎 穂高, 小川 和彦, 佐々木 良平, 芥田 敬三, 岡嶋 馨, 上紺屋 憲彦, 手島 昭樹, JASTRO DB委員会
    (公社)日本医学放射線学会, Feb. 2018, Japanese Journal of Radiology, 36(Suppl.) (Suppl.), 26 - 26, Japanese

  • 子宮頸癌化学放射線療法中のADC値の変化に関する検討 治療前と腔内照射直前の比較
    佐々木 香織, 西川 遼, 吉田 賢史, 赤坂 浩亮, 宮脇 大輔, 石原 武明, 江島 泰生, 佐々木 良平, 高橋 哲, 表田 真弓, 京谷 勉輔, 蛯名 康彦, 山田 秀人
    (公社)日本医学放射線学会, Feb. 2018, Japanese Journal of Radiology, 36(Suppl.) (Suppl.), 31 - 31, Japanese

  • 当院における子宮頸部腺癌の根治的放射線治療の治療成績の検討
    藤本 健士郎, 松尾 圭朗, 吉田 賢史, 川口 弘毅, 西川 遼, 石原 武明, 宮脇 大輔, 江島 泰生, 佐々木 良平, 蛯名 康彦
    (公社)日本医学放射線学会, Feb. 2018, Japanese Journal of Radiology, 36(Suppl.) (Suppl.), 36 - 36, Japanese

  • 放射線照射時における子宮頸部腺がん細胞から分泌される細胞外小胞体の機能解析-子宮温存を目指した子宮頸部腺がんの放射線治療抵抗性の克服にむけて-
    犬伏祥子, 吉田賢史, 佐々木良平
    2018, 女性健康科学研究会誌, 7(1) (1)

  • Development of bioabsorbable spacer for pediatric malignant tumors
    佐々木良平, 岩田宏満, 亀井美智, 出水祐介, 文野誠久, 中尾朋平, 中尾朋平, 淡河恵津世, 王天縁, 妹尾悟史, 犬伏祥子
    2018, 日本小児血液・がん学会雑誌(Web), 55(4) (4)

  • 胃癌切除術後の孤発性腹部リンパ節再発に対する強度変調放射線治療(IMRT)の初期経験
    馬屋原 博, 原田 文, 西村 英輝, 上薗 玄, 橋本 直樹, 川口 弘毅, 石原 武明, 西川 遼, 中山 雅央, 佐々木 良平, 藤井 正彦
    (一社)日本癌治療学会, Oct. 2017, 日本癌治療学会学術集会抄録集, 55回, P169 - 6, Japanese

  • 【転移性脊椎腫瘍に対する最小侵襲脊椎安定術(MISt)】 転移性脊椎腫瘍に対する出張型骨転移Cancer Boardの取り組み
    Kakutani Kenichiro, Sakai Yoshitada, 伊藤雅明, Kawamoto Teruya, Hara Hitomi, 深瀬直政, Okada Takuya, Sugimoto Koji, Miyawaki Daisuke, Sasaki Ryohei, Kiyota Naomi, Minami Hironobu, 秋末敏宏, Kuroda Ryosuke, 西田康太郎
    (株)全日本病院出版会, Sep. 2017, 整形外科最小侵襲手術ジャーナル, (84) (84), 79 - 83, Japanese
    [Refereed]
    Introduction scientific journal

  • 臨床応用を目指した消化器外科領域の基礎研究・橋渡し研究6 腹部悪性腫瘍に対する粒子線治療適応拡大を可能とする新規素材吸収性スペーサーの開発と臨床応用
    小松 昇平, 福本 巧, 木戸 正浩, 浅利 貞毅, 外山 博近, 味木 徹夫, 具 英成, 出水 祐介, 沖本 智昭, 佐々木 良平
    (一社)日本消化器外科学会, Jul. 2017, 日本消化器外科学会総会, 72回, O2 - 86, Japanese

  • 秋末 敏宏, 原 仁美, 角谷 賢一朗, 河本 旭哉, 深瀬 直政, 西田 康太郎, 江島 康生, 佐々木 良平, 黒田 良祐, 酒井 良忠
    (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1412 - S1412, Japanese

  • 個別化治療を目指した頭頸部癌診療ガイドライン 頭頸部がんに対する放射線治療の個別化 治療効果予測からの検討
    佐々木 良平, 宮脇 大輔, 清田 尚臣, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 144 - 144, Japanese

  • 局所進行頭頸部扁平上皮癌における導入化学療法TPFの安全性と有効性の検討
    長谷 善明, 清田 尚臣, 今村 善宜, 宮脇 大輔, 佐々木 良平, 四宮 弘隆, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 177 - 177, Japanese

  • 当院における嗅神経芽細胞腫症例の検討
    古川 竜也, 大月 直樹, 四宮 弘隆, 森田 成彦, 井之口 豪, 古閑 紀雄, 清田 尚臣, 佐々木 良平, 甲村 英二, 丹生 健一
    (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 205 - 205, Japanese

  • 有症状脊椎転移の発生リスクに関する前向き研究
    角谷 賢一朗, 酒井 良忠, 前野 耕一郎, 江島 泰生, 高田 徹, 由留部 崇, 佐々木 良平, 秋末 敏宏, 西田 康太郎, 黒田 良祐
    (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(2) (2), S179 - S179, Japanese

  • メタボローム解析を用いたグリオーマにおける新規バイオマーカーの探索
    甲村 英二, 篠山 隆司, 佐々木 良平, 細田 弘吉, 水川 克, 田中 一寛, 西原 賢在
    (地独)神戸市民病院機構, Mar. 2017, 神戸市立病院紀要, (55) (55), 104 - 104, Japanese

  • 鼻腔腫瘍に対する放射線治療の経験
    清家 翔平, 吉田 賢史, 宮脇 大輔, 石原 武明, 井上 由子, 松尾 圭朗, 西川 遼, ノル・シャズリナ, 江島 泰生, 佐々木 良平, 斎藤 幹, 大月 直樹, 丹生 健一
    (公社)日本医学放射線学会, Feb. 2017, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 41 - 41, Japanese

  • MLCの違いによる照射野外線量の検討
    赤坂 浩亮, 椋本 成俊, 王 天縁, 清水 康之, 大須賀 彩希, 吉田 賢史, 佐々木 良平, 南 利明, 吉田 直碁, 西尾 卓郎, 西谷 隆治, 青山 裕一
    (公社)日本医学放射線学会, Feb. 2017, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 41 - 41, Japanese

  • 当院におけるT3N0M0喉頭癌の放射線治療成績
    石原 武明, 松尾 圭朗, 西川 遼, 宮脇 大輔, 吉田 賢史, 江島 泰生, 佐々木 良平, 清田 尚臣, 森本 浩一, 斉藤 幹, 大月 直樹, 丹生 健一
    (公社)日本医学放射線学会, Feb. 2017, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 46 - 46, Japanese

  • 80歳以上の子宮頸癌患者に対する放射線治療の経験
    吉田 賢史, 西川 遼, 深澤 麻衣, 江島 泰生, 宮脇 大輔, 井上 由子, 松尾 圭郎, 石原 武明, 蝦名 康彦, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2017, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 50 - 50, Japanese

  • 放射線療法後の乳がんハンドブック作成の意義と評価 多施設共同による乳がん放射線療法後の患者サポートの試み
    大田 史江, 田中 幸江, 細見 裕久子, 上別府 幸子, 濱島 健児, 宮脇 大輔, 佐々木 良平
    (一社)日本がん看護学会, Jan. 2017, 日本がん看護学会誌, 31(Suppl.) (Suppl.), 266 - 266, Japanese

  • 肝臓 限局性肝がんに対する新たな治療選択肢 他治療が困難な肝細胞癌に対するサイバーナイフによる体幹部定位放射線治療
    馬屋原 博, 橋本 直樹, 西村 英輝, 原田 文, 上薗 玄, 中村 匡希, 松尾 圭朗, 江島 泰生, 石原 武明, 西川 遼, 中山 雅央, 佐々木 良平, 石田 淳, 藤井 正彦
    (一社)日本癌治療学会, Oct. 2016, 日本癌治療学会学術集会抄録集, 54回, WS35 - 6, Japanese

  • 角谷 賢一朗, 酒井 良忠, 由留部 崇, 前野 耕一郎, 原 仁美, 河本 旭哉, 岡田 卓也, 杉本 幸司, 江島 泰生, 佐々木 良平, AKISUE TOSHIHIRO, 黒坂 昌弘, 西田 康太郎
    (株)医学書院, Jul. 2016, 臨床整形外科, 51(7) (7), 601 - 605, Japanese
    [Invited]
    Introduction scientific journal

  • 秋末敏宏, 原仁美, Kakutani Kenichiro, 河本旭哉, 深瀬直政, Maeno Koichiro, Nishida Kotaro, 江島泰生, Sasaki Ryohei, Sakai Yoshitada
    (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1245 - S1245, Japanese
    [Refereed]
    Meeting report

  • セツキシマブ追加の有無による、再発性/転移性頭頸部癌の第一選択治療の比較(First-line Treatment of Recurrent/Metastatic Head and Neck Cancer with or without Cetuximab)
    今村 善宣, 清田 尚臣, 大月 直樹, 森本 浩一, 四宮 弘隆, 江島 泰生, 吉田 賢史, 南川 勉, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2) (2), 211 - 211, English

  • 吉田賢史, Miyawaki Daisuke, 清水康之, 西川遼, Sasaki Ryohei
    (株)日本臨床社, May 2016, 日本臨床, 74(増刊3 新前立腺癌学) (増刊3 新前立腺癌学), 503 - 507, Japanese
    [Invited]
    Introduction scientific journal

  • 【転移性脊椎腫瘍の治療戦略】 転移性脊椎腫瘍に対する最新の放射線治療
    Ejima Yasuo, 大須賀彩希, Sasaki Ryohei
    (株)メジカルビュー社, Apr. 2016, 関節外科, 35(4号) (4号), 354 - 359, Japanese
    [Invited]
    Introduction commerce magazine

  • 眼瞼周囲皮膚癌に対する新規眼球シールド使用時の線量分布の検討
    椋本 成俊, 宮脇 大輔, 赤坂 浩亮, 王 天縁, 清水 康之, 上薗 玄, 吉田 賢史, 江島 泰生, 佐々木 良平, 吉田 直碁, 表田 真弓, 西谷 隆治, 南 利明, 青山 裕一
    (公社)日本医学放射線学会, Feb. 2016, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 44 - 44, Japanese

  • Flattening Filter Freeビームを用いた頭頸部VMATの検討
    尾方 俊至, 上原 和之, 中山 雅央, 岡山 貴宣, 西村 英輝, 馬屋原 博, 原田 文, 松尾 圭朗, 藤井 正彦, 江島 泰生, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2016, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 50 - 50, Japanese

  • 当院におけるゼヴァリンの初期経験
    西川遼, 江島泰生, 吉田賢史, Miyawaki Daisuke, 上薗玄, 石原武明, ノル・シャズリナ, Sasaki Ryohei, Matsuoka Hiroshi, 薬師神公和
    (公社)日本医学放射線学会, Feb. 2016, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 49 - 49, Japanese
    [Refereed]
    Meeting report

  • Tomotherapy HDによる全脳全脊髄照射の有用性と課題
    馬屋原博, 尾方俊至, 西村英輝, 原田文, 上薗玄, 中村匡希, 江島泰生, 江島泰生, 松尾圭朗, 松尾圭朗, 宮脇大輔, 川端和彦, 岡山貴宣, 佐々木良平, 藤井正彦
    2016, 日本放射線腫瘍学会高精度放射線外部照射部会学術大会プログラム・抄録集, 29th

  • Hypofractionated Stereotactic Radiation Therapy Compared With Stereotactic Radiosurgery for Brain Metastases From Lung Cancer: Experience at a Single-Institution
    T. Ishihara, K. Yamada, A. Harada, K. Isogai, D. Miyawaki, K. Yoshida, Y. Ejima, R. Sasaki
    Nov. 2015, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93(3) (3), E71 - E71, English
    Summary international conference

  • Spinal Instability Is Associated With Local Failure After Radiation Therapy in Patients With Spinal Metastases
    Y. Ejima, K. Kakutani, Y. Sakai, K. Yoshida, D. Miyawaki, T. Ishihara, H. Hara, T. Akisue, K. Nishida, R. Sasaki
    Nov. 2015, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93(3) (3), E481 - E481, English
    Summary international conference

  • Radiation Therapy for T3/T4 Squamous Cell Carcinoma of Hypopharynx: A Retrospective Comparison Between Definitive Radiation Therapy and Surgery Followed by Postoperative Radiation Therapy
    Y. Matsuo, K. Yoshida, D. Miyawaki, Y. Ejima, T. Ishihara, R. Nishikawa, N. S. Sulaiman, Y. Inoue, H. Nishimura, N. Kiyota, M. Saito, N. Otsuki, K. Nibu, R. Sasaki
    Nov. 2015, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93(3) (3), E341 - E342, English
    Summary international conference

  • Masao Nakayama, Ryohei Sasaki, Toru Mukohara, Chiaki Ogino, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Kazuyoshi Sato, Chiya Numako, Seiichi Takami, Akihiko Kondo
    Aug. 2015, CANCER RESEARCH, 75, English
    Summary international conference

  • 酒井 良忠, 角谷 賢一朗, 原 仁美, 江島 泰生, 坂下 明大, 赤羽 志保, 河本 旭哉, 前野 耕一郎, 木澤 義之, 佐々木 良平, 西田 康太郎, 黒坂 昌弘, 秋末 敏宏
    (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1293 - S1293, Japanese

  • 原 仁美, 酒井 良忠, 河本 旭哉, 大西 康央, 蓑田 正也, 森下 雅之, 蒲田 悦子, 角谷 賢一朗, 江島 泰生, 坂下 明大, 佐々木 良平, 西田 康太郎, 黒坂 昌弘, 秋末 敏宏
    (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1320 - S1320, Japanese

  • 角谷 賢一朗, 酒井 良忠, 前野 耕一郎, 高田 徹, 由留部 崇, 蔵川 拓外, 宮崎 真吾, 寺嶋 良樹, 伊藤 雅明, 江島 泰生, 河本 旭哉, 原 仁美, 坂下 明大, 佐々木 良平, 秋末 敏宏, 黒坂 昌弘, 西田 康太郎
    (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1355 - S1355, Japanese

  • Flattening Filter Freeビームを用いた頭頸部VMATの検討 TomoTherapyとの比較
    上薗 玄, 尾方 俊至, 中山 雅央, 上原 和之, 津藤 真司, 馬屋原 博, 原田 文, 橋本 直樹, 岡山 貴宣, 藤井 正彦, 石原 武明, 江島 泰生, 宮脇 大輔, 佐々木 良平, 西村 英樹
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 207 - 207, Japanese

  • 中咽頭癌に対する化学放射線療法におけるPEGの有用性
    高橋 美貴, 小坂 奈々, 宇佐美 眞, 中川 絵美, 齋藤 幹, 大月 直樹, 佐々木 良平, 清田 尚臣, 丹生 健一
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 250 - 250, Japanese

  • 中・下咽頭後壁癌に対する放射線治療成績
    宮脇 大輔, 江島 泰生, 吉田 賢史, 石原 武明, 清田 尚臣, 斉藤 幹, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 254 - 254, Japanese

  • 食道癌同時合併中下咽頭癌に対する放射線治療の経験
    西川 遼, 吉田 賢史, 宮脇 大輔, 江島 泰生, 石原 武明, 松尾 佳朗, ノル・シャズリナ, 井上 由子, 西村 英輝, 清田 尚臣, 斎藤 幹, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 254 - 254, Japanese

  • 原発不明癌頸部リンパ節転移に対する放射線治療の経験
    井上 由子, 吉田 賢史, 江島 泰生, 宮脇 大輔, 石原 武明, ノル・シャズリナ, 西川 遼, 松尾 圭朗, 西村 英輝, 大月 直樹, 斎藤 幹, 清田 尚臣, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 262 - 262, Japanese

  • N3頸部リンパ節転移症例に対する放射線治療の経験
    吉田 賢史, 宮脇 大輔, 江島 泰生, 西村 英輝, 石原 武明, 松尾 佳朗, 西川 遼, 井上 由子, 清田 尚臣, 斎藤 幹, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 266 - 266, Japanese

  • Flattening Filter Freeビームを用いた頭頸部VMATの検討 Flattening Filter装填ビームとの比較
    西村 英輝, 尾方 俊至, 中山 雅央, 上原 和之, 津藤 真司, 馬屋原 博, 上薗 玄, 原田 文, 橋本 直樹, 岡山 貴宣, 江島 泰生, 石原 武明, 宮脇 大輔, 佐々木 良平, 藤井 正彦
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 266 - 266, Japanese

  • 再発頭頸部腫瘍に対するサイバーナイフによる救済治療の初期経験
    橋本 直樹, 西村 英輝, 馬屋原 博, 上薗 玄, 原田 文, 中山 雅央, 尾方 俊至, 斉藤 幹, 小松 弘和, 江島 泰生, 石原 武明, 松尾 圭朗, 宮脇 大輔, 佐々木 良平, 藤井 正彦
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 267 - 267, Japanese

  • 頭頸部粘表皮癌に対する粒子線(炭素線・陽子線)治療
    美馬 正幸, 出水 祐介, 金 東村, 高木 克, 永野 史子, 寺嶋 千貴, 藤井 收, 沖本 智昭, ノル・シャズリナ, 脇 隆博, 丹羽 康江, 森本 浩一, 佐々木 良平, 丹生 健一, 不破 信和
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 267 - 267, Japanese

  • EuroQOL-5D(EQ-5D)を用いた転移性脊椎腫瘍に対する手術加療の費用対効用
    宮崎 真吾, 角谷 賢一朗, 酒井 良忠, 前野 耕一郎, 高田 徹, 由留部 崇, 蔵川 拓外, 寺嶋 良樹, 江島 泰生, 河本 旭哉, 原 仁美, 坂下 明大, 佐々木 良平, 秋末 敏宏, 黒坂 昌弘, 西田 康太郎
    (一社)日本脊椎脊髄病学会, Mar. 2015, Journal of Spine Research, 6(3) (3), 486 - 486, Japanese

  • 高齢者脊椎転移に対する手術成績
    角谷 賢一朗, 酒井 良忠, 前野 耕一郎, 高田 徹, 由留部 崇, 蔵川 拓外, 宮崎 真吾, 寺島 良樹, 伊藤 雅明, 江島 泰生, 原 仁美, 坂下 明大, 佐々木 良平, 秋末 敏宏, 黒坂 昌弘, 西田 康太郎
    (一社)日本脊椎脊髄病学会, Mar. 2015, Journal of Spine Research, 6(3) (3), 518 - 518, Japanese

  • 骨転移専門tumor boardの取り組み
    角谷 賢一朗, 酒井 良忠, 前野 耕一郎, 高田 徹, 由留部 崇, 蔵川 拓外, 宮崎 真吾, 寺島 良樹, 伊藤 雅明, 江島 泰生, 原 仁美, 坂下 明大, 佐々木 良平, 秋末 敏宏, 黒坂 昌弘, 西田 康太郎
    (一社)日本脊椎脊髄病学会, Mar. 2015, Journal of Spine Research, 6(3) (3), 640 - 640, Japanese

  • 高齢者脊椎転移に対する手術成績
    角谷 賢一朗, 酒井 良忠, 前野 耕一郎, 高田 徹, 由留部 崇, 佐々木 良平, 木澤 義之, 秋末 敏宏, 西田 康太郎, 黒坂 昌弘
    (公社)日本整形外科学会, Mar. 2015, 日本整形外科学会雑誌, 89(3) (3), S667 - S667, Japanese

  • 若年者のgliomaに対する放射線治療の経験
    隅野 靖彬, 吉田 賢史, 江島 泰生, 宮脇 大輔, 西村 英輝, ノル・シャズリナ, 原田 文, 村岡 修, 佐々木 良平, 篠山 隆司, 早川 晶
    (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 64 - 64, Japanese

  • 成人型頭蓋外血管腫・血管奇形の放射線治療
    松尾 圭朗, 小島 芳夫, 吉田 賢史, 宮脇 大輔, 西村 英輝, 村岡 修, 原田 文, ノル・シャズリナ, 松本 葉子, 江島 泰生, 佐々木 良平, 山口 雅人
    (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 64 - 64, Japanese

  • 特発性眼窩炎症に対する放射線治療経験
    原田 文, 宮脇 大輔, 吉田 賢史, 江島 泰生, 西村 英輝, 佐々木 良平, 長井 隆行, 安積 淳
    (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 64 - 64, Japanese

  • 頭頸部傍神経節腫に対する放射線治療の経験
    酒井 徹也, 江島 泰生, 吉田 賢史, 宮脇 大輔, 上薗 玄, 松本 葉子, ノル・シャズリナ, 松尾 圭朗, 佐々木 良平, 斉藤 幹, 大月 直樹, 丹生 健一
    (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 70 - 70, Japanese

  • 鼻腔・副鼻腔腫瘍の治療計画における不均質補正の影響
    椋本 成俊, 吉田 賢史, 赤坂 浩亮, 江島 泰生, 宮脇 大輔, 上薗 玄, 佐々木 良平, 大月 直樹, 丹生 健一
    (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 70 - 70, Japanese

  • Flattening Filter Freeビームを用いた体幹部定位放射線治療の検討
    上原 和之, 尾方 俊至, 中山 雅央, 岡山 貴宣, 枡谷 隆史, 西村 英輝, 馬屋原 博, 原田 文, 藤井 正彦, 佐々木 良平, 江島 泰生, 上薗 玄
    (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 71 - 71, Japanese

  • 前立腺全摘術後のPSA再発に対する救済放射線治療の検討
    ノル・シャズリナ, 吉田 賢史, 宮脇 大輔, 江島 泰生, 上薗 玄, 松尾 圭朗, 西村 英輝, 佐々木 良平, 古川 順也, 藤澤 正人
    (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 71 - 71, Japanese

  • 頭頸部癌に対するセツキシマブ併用放射線治療の初期経験
    下山 真介, 上薗 玄, 松尾 圭朗, ノル・シャズリナ, 松本 葉子, 宮脇 大輔, 吉田 賢史, 江島 泰生, 佐々木 良平, 清田 尚臣, 大月 直樹, 丹生 健一
    (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 76 - 76, Japanese

  • 多施設共同による放射線療法後の患者サポートの試み
    細見 裕久子, 大田 史江, 長尾 綾子, 田中 幸江, 佐々木 良平, 宮脇 大輔, 浜島 健児
    (一社)日本がん看護学会, Jan. 2015, 日本がん看護学会誌, 29(Suppl.) (Suppl.), 188 - 188, Japanese

  • 大月 直樹, 四宮 弘隆, 小松 弘和, 森本 浩一, 齋藤 幹, 清田 尚臣, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, Dec. 2014, 頭頸部癌, 40(4) (4), 406 - 411, Japanese

  • 当院における再発・転移頭頸部がんに対するドセタキセル・シスプラチン併用(DC)療法の遡及的解析
    島田 貴信, 清田 尚臣, 今村 善宣, 森本 浩一, 斉藤 幹, 西村 英輝, 大月 直樹, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, Dec. 2014, 頭頸部癌, 40(4) (4), 490 - 496, Japanese

  • 術前FDG-PET/CTによる咽頭癌、咽頭癌の頸部リンパ節転移診断 CTとの対比
    末永 裕子, 北島 一宏, 河野 淳, 奥永 崇志, 武田 英治, 久保 和広, 丹生 健一, 佐々木 良平, 伊藤 智雄, 杉村 和朗
    (一社)日本核医学会, Nov. 2014, 核医学, 51(4) (4), 443 - 443, Japanese

  • Dose Estimation of Normal Brain Tissue Tolerance for Microbeam Radiation Therapy
    M. Nakayama, N. Mukumoto, H. Akasaka, D. Miyawaki, H. Nishimura, K. Umetani, N. Nariyama, T. Kondoh, K. Shinohara, R. Sasaki
    Sep. 2014, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 90, S804 - S804, English
    Summary international conference

  • Result of Multimodal Treatment Including Radiation Therapy for Squamous Cell Carcinomas of Maxillary Sinus: A Retrospective Study
    D. Miyawaki, Y. Ejima, H. Uezono, K. Yoshida, H. Nishimura, N. Otsuki, K. Nibu, R. Sasaki
    Sep. 2014, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 90, S544 - S544, English
    Summary international conference

  • 治療前FDG-PETによる喉頭癌の再発予測
    北島 一宏, 末永 裕子, 奥永 崇志, 久保 和広, 佐々木 良平, 丹生 健一, 清田 尚臣, 杉村 和朗
    (一社)日本核医学会, Sep. 2014, 核医学, 51(3) (3), 265 - 265, Japanese

  • 術前FDG-PET/CTによる咽頭癌、喉頭癌の頸部リンパ節転移診断 CTとの対比
    末永 裕子, 北島 一宏, 河野 淳, 奥永 崇志, 武田 英治, 久保 和広, 丹生 健一, 佐々木 良平, 伊藤 智雄, 杉村 和朗
    (一社)日本核医学会, Sep. 2014, 核医学, 51(3) (3), 265 - 265, Japanese

  • 多職種で取り組む放射線治療に関連した研修会立ち上げの実践報告と今後の課題
    大田 史江, 宮脇 大輔, 佐々木 良平
    (一社)日本放射線看護学会, Aug. 2014, 日本放射線看護学会学術集会講演集, 3回, 98 - 98, Japanese

  • 体内空間可変粒子線治療による肝胆膵癌の治療
    福本 巧, 木戸 正浩, 岡崎 太郎, 新関 亮, 松本 逸平, 味木 徹夫, 出水 祐介, 不和 信和, 佐々木 良平, 具 英成
    (一社)日本消化器外科学会, Jul. 2014, 日本消化器外科学会総会, 69回, O - 71, Japanese

  • 転移性骨腫瘍カンファレンス 転移性骨腫瘍に対するチームアプローチ 転移性骨腫瘍に対する放射線腫瘍医の考え方
    佐々木 良平, 江島 泰生
    (NPO)日本緩和医療学会, Jun. 2014, 日本緩和医療学会学術大会プログラム・抄録集, 19回, 182 - 182, Japanese

  • サイバーナイフVSIによるマーカーレス肺腫瘍動体追尾照射
    馬屋原 博, 松尾 圭朗, 原田 文, 西村 英輝, 中山 雅央, 上原 和之, 尾方 俊至, 江島 泰生, 宮脇 大輔, 上薗 玄, 佐々木 良平, 石田 淳, 藤井 正彦
    (一社)日本癌治療学会, Jun. 2014, 日本癌治療学会誌, 49(3) (3), 1069 - 1069, Japanese

  • 小線源療法後の下部尿路症状に対するシロドシンの予防効果を検討する無作為化比較試験
    村蒔 基次, 古川 順也, 三宅 秀明, 宮脇 大輔, 吉田 賢史, 佐々木 良平, 杉村 和朗, 藤澤 正人
    (一社)日本癌治療学会, Jun. 2014, 日本癌治療学会誌, 49(3) (3), 2659 - 2659, Japanese

  • サイバーナイフVSIによる体幹部定位放射線治療
    馬屋原 博, 松尾 圭朗, 原田 文, 西村 英輝, 中山 雅央, 上原 和之, 尾方 俊至, 江島 泰生, 宮脇 大輔, 上薗 玄, 佐々木 良平, 石田 淳, 藤井 正彦
    (一社)日本癌治療学会, Jun. 2014, 日本癌治療学会誌, 49(3) (3), 2700 - 2700, Japanese

  • 頭頸部進行がんに対する治療戦略 進行期喉頭癌・下咽頭癌に対する治療戦略
    大月 直樹, 四宮 弘隆, 小松 弘和, 森本 浩一, 齋藤 幹, 清田 尚臣, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 148 - 148, Japanese

  • T3N0-1声門癌に対する喉頭温存を目的とした根治的化学放射線治療の検討
    佐々木 良平, 松尾 圭朗, 江島 泰生, 宮脇 大輔, 上薗 玄, 今村 善宣, 清田 尚臣, 四宮 弘隆, 小松 弘和, 森本 浩一, 斉藤 幹, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 155 - 155, Japanese

  • 免疫組織化学染色による唾液腺導管癌15例の検討
    今村 善宣, 清田 尚臣, 大月 直樹, 山下 大介, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 186 - 186, Japanese

  • 当科における中咽頭癌症例の臨床的検討
    四宮 弘隆, 四宮 瞳, 小松 弘和, 森本 浩一, 齋藤 幹, 大月 直樹, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 195 - 195, Japanese

  • 中咽頭癌に対する化学放射線療法におけるPEG留置患者の栄養投与量と有害事象
    高橋 美貴, 小坂 奈々, 宇佐美 眞, 中川 絵美, 齋藤 幹, 大月 直樹, 江島 泰生, 宮脇 大輔, 佐々木 良平, 清田 尚臣, 丹生 健一
    (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 238 - 238, Japanese

  • 上顎洞扁平上皮癌に対する放射線治療成績
    宮脇 大輔, 江島 泰生, 上薗 玄, 四宮 弘隆, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 264 - 264, Japanese

  • 頭頸部癌に対するセツキシマブ併用放射線治療の初期経験
    上薗 玄, 江島 泰生, 宮脇 大輔, 四宮 弘隆, 小松 弘和, 藤尾 久美, 森本 浩一, 今村 善宣, 斉藤 幹, 大月 直樹, 清田 尚臣, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 265 - 265, Japanese

  • 遠隔画像診断システムを利用した放射線治療のコンサルテーション
    藤井 正彦, 西村 英輝, 小西 淳也, 佐々木 良平, 杉村 和朗
    産業開発機構(株), Apr. 2014, 映像情報Medical, 46(4) (4), 348 - 349, Japanese

  • 転移性脊椎腫瘍に対する放射線療法の現況
    佐々木 良平
    (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(3) (3), S925 - S925, Japanese

  • 転移性脊椎腫瘍への最新の知見 転移性脊椎腫瘍に対する手術成績 手術、非手術例の生命予後、全身状態、日常生活動作に関する前向き研究
    角谷 賢一朗, 酒井 良忠, 前野 耕一郎, 高田 徹, 江島 泰生, 原 仁美, 坂下 明大, 佐々木 良平, 秋末 敏宏, 西田 康太郎, 黒坂 昌弘
    (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(3) (3), S930 - S930, Japanese

  • 転移性脊椎腫瘍患者の手術、非手術例における生命予後、歩行状態に関する前向き研究
    角谷 賢一朗, 酒井 良忠, 前野 耕一郎, 高田 徹, 江島 泰生, 原 仁美, 坂下 明大, 平田 裕亮, 蔵川 拓外, 宮崎 真吾, 寺嶋 良樹, 佐々木 良平, 秋末 敏宏, 黒坂 昌弘, 西田 康太郎
    (一社)日本脊椎脊髄病学会, Mar. 2014, Journal of Spine Research, 5(3) (3), 487 - 487, Japanese

  • 高悪性度転移性脊椎腫瘍患者の手術例における全身状態、日常生活動作に関する前向き研究
    角谷 賢一朗, 前野 耕一郎, 酒井 良忠, 高田 徹, 江島 泰生, 原 仁美, 坂下 明大, 平田 裕亮, 蔵川 拓外, 宮崎 真吾, 寺嶋 良樹, 佐々木 良平, 秋末 敏宏, 黒坂 昌弘, 西田 康太郎
    (一社)日本脊椎脊髄病学会, Mar. 2014, Journal of Spine Research, 5(3) (3), 570 - 570, Japanese

  • 脳幹部腫瘍に対する放射線治療の経験
    ノル・シャズリナ, 吉田 賢史, 西村 英輝, 宮脇 大輔, 原田 文, 村岡 修, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2014, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 30 - 30, Japanese

  • 喉頭原発悪性リンパ腫に対する放射線治療の経験
    井上 由子, 吉田 賢史, 宮脇 大輔, 西村 英輝, 原田 文, 村岡 修, ノル・シャズリナ, 佐々木 良平, 岡村 篤夫, 斎藤 幹, 丹生 健一
    (公社)日本医学放射線学会, Feb. 2014, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 36 - 36, Japanese

  • 過酸化チタンナノ粒子による放射線増感の検討
    中山 雅央, 佐々木 良平, 西村 英輝, 吉田 賢史, 宮脇 大輔, 赤坂 浩亮, 椋本 成俊, 村岡 修, 原田 文, ノル・シャズリナ, 上原 和之, 田中 勉, 荻野 千秋, 近藤 昭彦
    (公社)日本医学放射線学会, Feb. 2014, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 37 - 37, Japanese

  • HIV陽性患者に発生した悪性腫瘍に対する放射線治療の経験
    水沼 優子, 宮脇 大輔, 西村 英輝, 江島 泰生, 吉田 賢史, 原田 文, 村岡 修, ノル・シャズリナ, 松本 葉子, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2014, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 42 - 42, Japanese

  • Sasaki Ryohei, Miyawaki Daisuke
    (一財)日本消化器病学会, Dec. 2013, 日本消化器病学会雑誌, 110(12号) (12号), 2073 - 2080, Japanese
    [Refereed][Invited]
    Introduction scientific journal

  • 塩化ストロンチウム89SrCl2(メタストロン注)治療において転移性骨腫瘍に様々な抗腫瘍効果を呈した胆管細胞癌の1例
    酒井 英郎, 増田 裕美子, 佐藤 美晴, 松井 祥治, 太田 恭介, 佐々木 良平, 宮脇 大輔
    (株)癌と化学療法社, Nov. 2013, 癌と化学療法, 40(12) (12), 1856 - 1858, Japanese

  • Radiation-Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: Comparison Between Concurrent Chemoradiation Therapy and Radiation Therapy Alone
    D. Miyawaki, K. Yoshida, Y. Ejima, H. Nishimura, N. S. Sulaiman, N. Kiyota, M. Saito, N. Otsuki, K. Nibu, R. Sasaki
    Oct. 2013, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 87(2) (2), S472 - S473, English
    Summary international conference

  • Efficacy of Salvage Radiation Therapy in Men With Biochemical Recurrence After Radical Prostatectomy: A Comparison With Endocrine Therapy
    N. Suleiman, K. Yoshida, D. Miyawaki, Y. Ejima, H. Nishimura, J. Furukawa, M. Fujisawa, R. Sasaki
    Oct. 2013, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 87(2) (2), S366 - S366, English
    Summary international conference

  • 根治的化学放射線療法を施行した原発性肺癌における放射線肺臓炎のリスク因子の検討
    徳永 俊太郎, 石川 結美子, 新家 治子, 立原 素子, 神山 久信, Ejima Yasuo, 小林 和幸, 船田 泰弘, 小谷 義一, Sasaki Ryohei, 大野 良治, 西村 善博
    (NPO)日本肺癌学会, Oct. 2013, 肺癌, 53(5号) (5号), 642 - 642, Japanese
    Meeting report

  • 放射線科中心の特殊センターでの画像診断とPACS 遠隔画像診断システムを利用した放射線治療のコンサルテーション
    藤井 正彦, 西村 英輝, 小西 淳也, 佐々木 良平, 杉村 和朗
    (公社)日本医学放射線学会, Sep. 2013, 日本医学放射線学会秋季臨床大会抄録集, 49回, S592 - S592, Japanese

  • スペーサー手術と粒子線照射による腹部・骨盤部悪性腫瘍の治療
    福本 巧, Kito Masahiro, 武部 敦志, 田中 基文, 蔵満 薫, 木下 秘我, 小松 昇平, 松本 逸平, 味木 徹夫, 出水 祐介, 不破 信和, Sasaki Ryohei, 具 英成
    (一社)日本癌治療学会, Sep. 2013, 日本癌治療学会誌, 48(3) (3), 1174 - 1174, Japanese
    [Refereed]
    Meeting report

  • 放射線療法チームのスキルミクスと看護の役割
    Sasaki Ryohei, 宮脇大輔, 藤原由香
    Jul. 2013, がん看護, 18(5) (5), 110 - 115, Japanese
    Others

  • 子宮頸癌放射線治療の新展開 高齢子宮頸癌患者に対する根治的放射線治療の経験
    吉田 賢史, Miyawaki Daisuke, Ejima Yasuo, 西村 英輝, 岡本 欣晃, 蝦名 康彦, Sasaki Ryohei
    (公社)日本婦人科腫瘍学会, Jun. 2013, 日本婦人科腫瘍学会雑誌, 31(3号) (3号), 412 - 412, Japanese
    Meeting report

  • 放射線治療計画装置を用いたkV-CBCT吸収線量評価 前立腺がん放射線治療に及ぼす影響
    川村 哲朗, 村上 直基, 岡村 佳明, 西村 英輝, 宮脇 大輔, 木村 邦彦, 土師 守, 佐々木 良平
    (公社)日本放射線技術学会, May 2013, 日本放射線技術学会雑誌, 69(5) (5), 491 - 499, Japanese

  • 鼻腔原発NK/T細胞リンパ腫に対する放射線治療経験
    原田 文, Miyawaki Daisuke, 西村 英輝, Ejima Yasuo, 吉田 賢史, Yakushijin Kimikazu, 松岡 広, 土井 清司, 大月 直樹, 丹生 健一, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 264 - 264, Japanese
    Meeting report

  • 頭頸部扁平上皮癌に対する放射線治療後の甲状腺機能低下症に関する検討
    Miyawaki Daisuke, 吉田 賢史, Ejima Yasuo, 西村 英輝, 岡本 欣晃, Kiyota Naomi, 斉藤 幹, 大月 直樹, 丹生 健一, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 262 - 262, Japanese
    Meeting report

  • 当院におけるT3喉頭癌の放射線治療の経験
    松尾 圭朗, 吉田 賢史, Miyawaki Daisuke, Ejima Yasuo, Kiyota Naomi, 斎藤 幹, 大月 直樹, 丹生 健一, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 186 - 186, Japanese
    Meeting report

  • 進行舌癌に対する術後放射線治療の経験
    吉田 賢史, Miyawaki Daisuke, Ejima Yasuo, 西村 英輝, Kiyota Naomi, 南川 勉, 斉藤 幹, 大月 直樹, 丹生 健一, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 250 - 250, Japanese
    Meeting report

  • 耳下腺癌/顎下腺癌術後症例に対する放射線治療の検討
    村岡 修, Miyawaki Daisuke, 西村 英輝, 吉田 賢史, Ejima Yasuo, 大月 直樹, Morimoto Koichi, 山下 大介, 丹生 健一, 岡本 欣晃, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 233 - 233, Japanese
    Meeting report

  • 甲状腺原発MALTリンパ腫の治療経験
    Ejima Yasuo, 吉田 賢史, Miyawaki Daisuke, 西村 英輝, 岡本 欣晃, 副島 俊典, 松岡 広, 大月 直樹, 丹生 健一, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 237 - 237, Japanese
    Meeting report

  • T1/2声門上癌に対する放射線治療成績の検討
    松本 葉子, 吉田 賢史, Ejima Yasuo, Miyawaki Daisuke, 西村 英輝, 斉藤 幹, 大月 直樹, 丹生 健一, Kiyota Naomi, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 264 - 264, Japanese
    Meeting report

  • 5年以上経過観察した上咽頭癌症例に関する放射線療法の晩期有害反応の検討
    Sasaki Ryohei, Ejima Yasuo, 吉田 賢史, Miyawaki Daisuke, 西村 英輝, 岡本 欣晃, 山下 大介, 長谷川 信吾, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 184 - 184, Japanese
    Meeting report

  • 低悪性度神経膠腫に対する放射線治療の経験(Clinical outcomes of radiotherapy for low-grade glioma)
    ノル・シャズリナ, 吉田 賢史, 篠山 隆司, 西村 英輝, 宮脇 大輔, 原田 文, 村岡 修, 松本 葉子, 江島 泰生, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2013, 日本医学放射線学会学術集会抄録集, 72回, S269 - S269, English

  • 低悪性度神経膠腫に対する放射線治療の経験(Clinical outcomes of radiotherapy for low-grade glioma)
    ノル・シャズリナ, 吉田 賢史, 篠山 隆司, 西村 英輝, 宮脇 大輔, 原田 文, 村岡 修, 松本 葉子, 江島 泰生, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2013, 日本医学放射線学会学術集会抄録集, 72回(72回) (72回), S269 - S269, English
    Meeting report

  • 食道小細胞癌に対する放射線治療の経験
    松本 葉子, 吉田 賢史, 西村 英輝, Ejima Yasuo, Miyawaki Daisuke, 原田 文, ノル・シャズリナ, 村岡 修, Sasaki Ryohei
    (公社)日本医学放射線学会, Feb. 2013, 日本医学放射線学会学術集会抄録集, 72回(72回) (72回), S386 - S386, Japanese
    Meeting report

  • Novel Radiosensitization Through Reactive Oxygen Species Generation Using Titanium Peroxide Nanoparticle Compounds Against Pancreas Cancer
    M. Nakayama, R. Sasaki, C. Ogino, T. Tanaka, M. Umetsu, S. Ohara, Z. Tan, K. Sato, C. Numako, A. Kondo
    Nov. 2012, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 84(3) (3), S700 - S700, English
    Summary international conference

  • Involved-Field Radiation Therapy Using Protons or Carbon Ions for N1-2M0 Non-small Cell Lung Cancer: A Retrospective Study
    O. Fujii, N. Hashimoto, K. Terashima, M. Mima, Y. Demizu, Y. Niwa, R. Sasaki, Y. Hishikawa, M. Abe, M. Murakami
    Nov. 2012, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 84(3) (3), S550 - S550, English
    Summary international conference

  • Stereotactic Body Radiation Therapy in 95 Patients With Lung Tumors Composed of Ground-glass Opacity (GGO): Results of a Retrospective Multicenter Study
    H. Onishi, Y. Shioyama, Y. Matsumoto, Y. Shibamoto, A. Miyakawa, G. Suzuki, R. Sasaki, D. Miyawaki, Y. Nishimura, R. Ryusuke
    Nov. 2012, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 84(3) (3), S49 - S49, English
    Summary international conference

  • Patterns of Local Recurrence and Metachronous Malignancy Following Radiation Therapy for Stage I or II Hypopharyngeal Carcinoma: Role of Close Observation and Multidisciplinary Approach
    H. Nishimura, R. Sasaki, K. Yoshida, D. Miyawaki, Y. Okamoto, N. Kiyota, M. Saito, N. Otsuki, K. Nibu
    Nov. 2012, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 84(3) (3), S491 - S491, English
    Summary international conference

  • A PILOT RANDOMIZED TRIAL COMPARING STANDARD PAIN CONTROL WITH OR WITHOUT GABAPENTIN FOR THE TREATMENT OF PAIN RELATED TO RADIATION-INDUCED MUCOSITIS IN HEAD AND NECK CANCER
    T. Kataoka, N. Kiyota, T. Shimada, Y. Imamura, N. Chayahara, M. Toyoda, Y. Funakoshi, H. Tomioka, Y. Fujiwara, K. Nibu, T. Komori, H. Nishimura, R. Sasaki, T. Mukohara, H. Minami
    Oct. 2012, ANNALS OF ONCOLOGY, 23, 91 - 91, English
    Summary international conference

  • 【再照射】頭頸部癌X線・粒子線治療後再発に対して粒子線再照射を施行した症例の検討
    出水 祐介, 金 東村, 荒屋 正幸, 橋本 直樹, 寺嶋 千貴, 美馬 正幸, 藤井 收, 丹羽 康江, 佐々木 良平, 菱川 良夫, 阿部 光幸, 村上 昌雄
    (株)篠原出版新社, Aug. 2012, 癌の臨床, 58(4) (4), 157 - 163, Japanese

  • AIDS患者の中咽頭扁平上皮癌に対する治療経験
    Fujita Takeshi, Yoshida Kenji, Sasaki Ryohei, Ohtsuki Naoki, Nibu Ken-ichi
    Jun. 2012, 第36回日本頭頸部癌学会, Japanese
    [Invited]
    Summary national conference

  • 頭頸部癌患者における放射線性粘膜炎による疼痛に対するガバペンチンのパイロット・ランダム化比較試験
    片岡 智子, 清田 尚臣, 島田 貴信, 今村 善宣, 茶屋原 菜穂子, 豊田 昌徳, 船越 洋平, 富岡 秀夫, 藤原 豊, 丹生 健一, 古森 孝英, 西村 英輝, 佐々木 良平, 向原 徹, 南 博信
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 188 - 188, Japanese

  • T1-T3N0声門癌の喉頭温存を目指した治療方針の検討
    原田 文, 宮脇 大輔, 吉田 賢史, 西村 英輝, 村岡 修, ノル・シャズリナ, 斉藤 幹, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 191 - 191, Japanese

  • 当院における中咽頭扁平上皮癌に対する放射線治療成績
    宮脇 大輔, 西村 英輝, 吉田 賢史, 原田 文, 村岡 修, ノル・シャズリナ, 清田 尚臣, 斎藤 幹, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 195 - 195, Japanese

  • 顔面・頭頸部に発生した血管原性腫瘍に対する放射線治療の経験
    佐々木 良平, 西村 英輝, 吉田 賢史, 宮脇 大輔, 森本 浩一, 米澤 宏一郎, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 221 - 221, Japanese

  • 患者の中咽頭扁平上皮癌に対する治療経験
    林 拓二, 藤田 岳, 吉田 賢史, 西村 英輝, 佐々木 良平, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 224 - 224, Japanese

  • 頸部リンパ節転移を認めた原発不明悪性黒色腫の2例
    米澤 宏一郎, 森本 浩一, 山下 大介, 谷本 均, 斉藤 幹, 大月 直樹, 丹生 健一, 清田 尚臣, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 226 - 226, Japanese

  • 頭頸部粘膜悪性黒色腫に対する粒子線治療成績 陽子線治療と炭素線治療の比較
    出水 祐介, 橋本 直樹, 寺嶋 千貴, 美馬 正幸, 藤井 收, 丹羽 康江, 金 東村, 荒屋 正幸, 森本 浩一, 佐々木 良平, 村上 昌雄
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 226 - 226, Japanese

  • 多診療科共同で集学的治療を行った頭頸部原発骨軟部肉腫の2例
    島田 貴信, 清田 尚臣, 米澤 宏一郎, 土井 清司, 長谷川 信吾, 西村 英輝, 佐々木 良平, 南川 勉, 橋川 和信, 田原 真一, 丹生 健一
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 231 - 231, Japanese

  • 鼻腔悪性黒色腫に対する大線量小分割法放射線治療の経験
    ノル・シャズリナ, 吉田 賢史, 西村 英輝, 宮脇 大輔, 原田 文, 村岡 修, 岡本 欣晃, 土井 清司, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 244 - 244, Japanese

  • 高齢頭頸部癌患者に対する放射線治療の経験 10年間の検討
    吉田 賢史, 西村 英輝, 宮脇 大輔, 村岡 修, 原田 文, ノル・シャズリナ, 斎藤 幹, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 248 - 248, Japanese

  • 顎下腺癌に対する放射線療法の経験
    村岡 修, 宮脇 大輔, 西村 英輝, 吉田 賢史, 原田 文, ノル・シャズリナ, 大月 直樹, 柴田 智久, 米澤 宏一郎, 森本 浩一, 山下 大介, 丹生 健一, 岡本 欣晃, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 267 - 267, Japanese

  • Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus - a Retrospective Study
    D. Miyawaki, H. Nishimura, K. Yoshida, O. Muraoka, M. Nakayama, K. Uehara, K. Sugimura, S. Hasegawa, K. Nibu, R. Sasaki
    Sep. 2011, EUROPEAN JOURNAL OF CANCER, 47, S563 - S563, English
    Summary international conference

  • 進行下部直腸癌に対するUFT/LVを用いた術前化学放射線療法第I相試験
    山下 公大, 中村 哲, 神垣 隆, 高瀬 至郎, 西村 英輝, 佐々木 良平, 金光 聖哲, 長谷川 寛, 松田 佳子, 安田 貴志, 今西 達也, 角 泰雄, 鈴木 知志, 具 英成, 黒田 大介
    (一社)日本癌治療学会, Sep. 2011, 日本癌治療学会誌, 46(2) (2), 479 - 479, Japanese

  • 当院における進行食道癌の放射線及び化学放射線治療の長期予後を踏まえた検討
    池田 篤紀, 奥野 達哉, 今西 達也, 中村 哲, 西村 英輝, 佐々木 良平, 黒田 大介, 田村 孝雄, 東 健
    (一社)日本癌治療学会, Sep. 2011, 日本癌治療学会誌, 46(2) (2), 638 - 638, Japanese

  • 精巣腫瘍(seminoma)に対する放射線治療の経験
    ノル・シャズリナ・スライマン, 吉田 賢史, 西村 英輝, 宮脇 大輔, 村岡 修, 原田 文, 佐々木 良平, 副島 俊典, 岡本 欣晃
    (一社)日本癌治療学会, Sep. 2011, 日本癌治療学会誌, 46(2) (2), 734 - 734, Japanese

  • 上顎洞扁平上皮癌に対する放射線治療成績
    宮脇 大輔, 西村 英輝, 吉田 賢史, 原田 文, 村岡 修, ノル・シャズリナ, 中山 雅央, 上原 和之, 赤坂 浩亮, 椋本 成俊, 土井 清司, 山下 大介, 長谷川 信吾, 丹生 健一, 佐々木 良平
    (一社)日本癌治療学会, Sep. 2011, 日本癌治療学会誌, 46(2) (2), 786 - 786, Japanese

  • 脳幹部腫瘍に対する放射線治療の経験
    吉田 賢史, 西村 英輝, 宮脇 大輔, 村岡 修, 原田 文, ノル・シャズリナ・スライマン, 佐々木 良平, 副島 俊典, 岡本 欣晃
    (一社)日本癌治療学会, Sep. 2011, 日本癌治療学会誌, 46(2) (2), 884 - 884, Japanese

  • 転移性脳腫瘍に対する分割定位放射線治療の経験
    原田 文, 山田 和成, 石原 武明, 吉田 賢史, 西村 英輝, 佐々木 良平
    (一社)日本癌治療学会, Sep. 2011, 日本癌治療学会誌, 46(2) (2), 884 - 884, Japanese

  • 局所進行切除不能食道癌(T4/M1LYM)に対する化学放射線療法の遡及的検討
    西村 英輝, 関井 修平, 吉田 賢史, 宮脇 大輔, 村岡 修, 奥野 達哉, 清田 尚臣, 岡本 欣晃, 副島 俊典, 佐々木 良平
    (NPO)日本食道学会, Sep. 2011, 日本食道学会学術集会プログラム・抄録集, 65回, 323 - 323, Japanese

  • 頭頸部腺様嚢胞癌に対する粒子線(陽子線・炭素線)単独治療成績
    出水 祐介, 寺嶋 千貴, 美馬 正幸, 藤井 收, 丹羽 康江, 森本 浩一, 宮脇 大輔, 佐々木 良平, 村上 昌雄
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 215 - 215, Japanese

  • 頭蓋底浸潤を認めた頭頸部癌に対する粒子線治療成績
    森本 浩一, 出水 祐介, 寺嶋 千貴, 美馬 正幸, 藤井 收, 丹羽 康江, 宮脇 大輔, 佐々木 良平, 村上 昌雄, 丹生 健一
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 219 - 219, Japanese

  • 頭頸部皮膚血管肉腫に対するRecursive partitioning analysis(RPA)の検討
    佐々木 良平, 西村 英輝, 吉田 賢史, 宮脇 大輔, 村岡 修, 橋本 直樹, 副島 俊典, 藤井 收, 尾藤 利憲, 丹生 健一
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 228 - 228, Japanese

  • 当科における顎下腺癌手術症例の検討
    大月 直樹, 柴田 智久, 米澤 宏一郎, 森本 浩一, 山下 大介, 村岡 修, 宮脇 大輔, 吉田 賢史, 西村 英輝, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 245 - 245, Japanese

  • 当科における喉頭機能温存手術の検討
    米澤 宏一郎, 森本 浩一, 齋藤 幹, 大月 直樹, 清田 尚臣, 西村 英輝, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 249 - 249, Japanese

  • 上顎洞扁平上皮癌に対する放射線治療成績
    宮脇 大輔, 西村 英輝, 吉田 賢史, 村岡 修, 岡本 欣晃, 土井 清司, 山下 大介, 長谷川 信吾, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 257 - 257, Japanese

  • 遊離空腸再建後の高リスク頭頸部癌に対する術後放射線治療の検討
    西村 英輝, 佐々木 良平, 吉田 賢史, 宮脇 大輔, 丹生 健一, 大月 直樹, 斉藤 幹, 清田 尚臣, 岡本 欣晃, 副島 俊典
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 257 - 257, Japanese

  • 切除不能頭頸部癌に対するSequential therapyの安全性に関する後向き研究
    島田 貴信, 清田 尚臣, 大月 直樹, 丹生 健一, 西村 英輝, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 258 - 258, Japanese

  • 耳下腺癌術後症例に対する放射線治療の経験
    村岡 修, 宮脇 大輔, 吉田 賢史, 西村 英輝, 柴田 智久, 米澤 宏一郎, 森本 浩一, 山下 大介, 大月 直樹, 丹生 健一, 岡本 欣晃, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 303 - 303, Japanese

  • 局所進行外耳道扁平上皮癌に対する3剤(TPF)併用化学放射線療法の経験
    吉田 賢史, 西村 英輝, 宮脇 大輔, 村岡 修, 佐々木 良平, 清田 尚臣, 土井 清司, 長谷川 信吾, 丹生 健一
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 320 - 320, Japanese

  • 【治療に伴う看護特集 一問一答でいちからわかる、きちんとわかる!がん放射線療法と看護】一問一答で"きちんと"わかる がん放射線治療の基礎知識
    佐々木 良平, 西村 英輝, 椋本 成俊
    (株)メディカ出版, Apr. 2011, プロフェッショナルがんナーシング, 1(2) (2), 204 - 217, Japanese

  • 西村 英輝, 佐々木 良平, 吉田 賢史, 宮脇 大輔, 大月 直樹, 斉藤 幹, 清田 尚臣, 副島 俊典, 杉村 和朗, 丹生 健一
    (一社)日本頭頸部癌学会, Apr. 2011, 頭頸部癌, 37(1) (1), 62 - 66, Japanese

  • 耳下腺癌における予防的頸部郭清と術後放射線治療について
    柴田 智久, 米澤 宏一郎, 森本 浩一, 山下 大介, 大月 直樹, 西村 英輝, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, Apr. 2011, 頭頸部癌, 37(1) (1), 78 - 82, Japanese

  • 1・2期下咽頭癌に対する放射線治療成績の検討
    宮脇 大輔, 西村 英輝, 吉田 賢史, 橋本 直樹, 村岡 修, 中山 雅央, 上原 和之, 菊川 久美子, 丹生 健一, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S297 - S297, Japanese

  • 鼻腔NK/T細胞性リンパ腫に対する放射線治療の経験
    橋本 直樹, 宮脇 大輔, 西村 英輝, 吉田 賢史, 村岡 修, 中山 雅央, 上原 和之, 松岡 広, 丹生 健一, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S349 - S350, Japanese

  • 局所進行外耳道扁平上皮癌に対する3剤(TPF)併用化学放射線療法の経験
    難波 富美子, 吉田 賢史, 西村 英輝, 宮脇 大輔, 橋本 直樹, 村岡 修, 佐々木 良平, 清田 尚臣, 長谷川 信吾, 丹生 健一
    (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S353 - S353, Japanese

  • 原発不明癌頸部リンパ節転移に対する治療経験
    村岡 修, 吉田 賢史, 西村 英輝, 宮脇 大輔, 清田 尚臣, 斎藤 幹, 大月 直樹, 丹生 健一, 岡本 欣晃, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S354 - S354, Japanese

  • 精巣腫瘍(seminoma)に対する放射線治療の経験
    吉田 賢史, 西村 英輝, 宮脇 大輔, 村岡 修, 橋本 直樹, 中山 雅央, 上原 和之, 副島 俊典, 岡本 欣晃, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S373 - S373, Japanese

  • Dosimetric Analysis of Patterns of Failure for High-grade Glioma with Multimodality Treatment: Relationship to MIB-1 Labeling Index
    K. Uehara, R. Sasaki, D. Miyawaki, H. Nishimura, K. Yoshida, M. Nakayama, T. Soejima, O. Fujii, T. Sasayama, K. Sugimura
    2011, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81(2) (2), S281 - S282, English
    Summary international conference

  • Treatment Outcomes of Particle Radiotherapy using Protons or Carbon Ions as a Single-modality Therapy for Adenoid Cystic Carcinoma of the Head and Neck
    Y. Demizu, K. Terashima, M. Mima, O. Fujii, Y. Niwa, K. Morimoto, R. Sasaki, Y. Hishikawa, M. Abe, M. Murakami
    2011, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81(2) (2), S179 - S179, English
    Summary international conference

  • Proton Beam Therapy and Carbon-ion Radiotherapy for T2a-T2bN0M0 Non-small Cell Lung Cancer
    H. Iwata, Y. Demizu, K. Terashima, M. Mima, O. Fujii, Y. Niwa, D. Miyawaki, R. Sasaki, Y. Shibamoto, M. Murakami
    2011, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81(2) (2), S574 - S574, English
    Summary international conference

  • Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus: A Retrospective Study
    D. Miyawaki, H. Nishimura, K. Yoshida, O. Muraoka, M. Nakayama, K. Uehara, S. Hasegawa, K. Nibu, K. Sugimura, R. Sasaki
    2011, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81(2) (2), S523 - S524, English
    Summary international conference

  • Long-term Outcome and Patterns of Failure in Primary Ocular Adnexal MALT Lymphoma Treated with Radiotherapy
    N. Hashimoto, R. Sasaki, H. Nishimura, K. Yoshida, D. Miyawaki, Y. Okamoto, Y. Ejima, A. Azumi, T. Matsui, K. Sugimura
    2011, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81(2) (2), S630 - S630, English
    Summary international conference

  • Bone Injury after Definitive Radiotherapy for Uterine Cervical Cancer: Retrospective Analysis of Risk Factors
    H. Uezono, K. Tsujino, K. Moriki, Y. Matsumoto, F. Nagano, Y. Ota, K. Sugimura, R. Sasaki, T. Soejima
    2011, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81(2) (2), S461 - S461, English
    Summary international conference

  • Radiation Therapy for Brain Stem Gliomas in Children and Adults
    K. Yoshida, H. Nishimura, D. Miyawaki, O. Muraoka, K. Uehara, M. Nakayama, R. Sasaki, K. Sugimura
    2011, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81(2) (2), S285 - S285, English
    Summary international conference

  • 聴器扁平上皮癌に対する放射線治療経験
    中林 美日, 吉田 賢史, 佐々木 良平, 岡本 欣晃, 西村 英輝, 河辺 哲也, 長谷川 信吾, 斉藤 幹, 大月 直樹, 丹生 健一
    (公社)日本医学放射線学会, Jan. 2011, Japanese Journal of Radiology, 29(Suppl.I) (Suppl.I), 43 - 43, Japanese

  • 限局型小細胞肺癌に対する化学放射線療法の治療成績
    上薗 玄, 西村 英輝, 佐々木 良平, 河辺 哲也, 吉田 賢史, 宮脇 大輔, 石原 武明, 杉村 和朗
    (公社)日本医学放射線学会, Jan. 2011, Japanese Journal of Radiology, 29(Suppl.I) (Suppl.I), 48 - 48, Japanese

  • 門脈腫瘍栓(Vp3、Vp4)かつ多発肝内転移を伴う肝細胞癌に対する動注化学療法同時併用粒子線治療の初期経験
    寺嶋 千貴, 村上 昌雄, 有村 健, 丹羽 康江, 出水 祐介, 菱川 良夫, 宮脇 大輔, 佐々木 良平
    (公社)日本医学放射線学会, Jan. 2011, Japanese Journal of Radiology, 29(Suppl.I) (Suppl.I), 48 - 48, Japanese

  • HPV-DNA検出による中咽頭癌の化学放射線療法感受性予測
    太田 陽介, 鍬塚 葉子, 原田 文, 藤井 收, 辻野 佳世子, 副島 俊典, 佐々木 良平
    (公社)日本医学放射線学会, Jan. 2011, Japanese Journal of Radiology, 29(Suppl.I) (Suppl.I), 55 - 55, Japanese

  • 当院における中枢神経原発悪性リンパ腫に対する放射線治療の遡及的検討
    石原 武明, 吉田 賢史, 佐々木 良平, 西村 英輝, 河邉 哲也, 宮脇 大輔, 上園 玄, 上原 和之, 中山 雅央, 杉村 和朗, 篠山 隆, 甲村 英二
    (公社)日本医学放射線学会, Jan. 2011, Japanese Journal of Radiology, 29(Suppl.I) (Suppl.I), 55 - 55, Japanese

  • 肝細胞癌に対する粒子線治療前TACEの有効性の検討
    寺嶋 千貴, 村上 昌雄, 美馬 正幸, 丹羽 康江, 出水 祐介, 菱川 良夫, 佐々木 良平, 宮脇 大輔, 小松 昇平
    (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 69回, S195 - S195, Japanese

  • 鼻外突出型巨大鼻腔腫瘍に対する粒子線治療経験
    美馬 正幸, 村上 昌雄, 出水 祐介, 寺嶋 千貴, 丹羽 康江, 菱川 良夫, 宮脇 大輔, 佐々木 良平, 杉村 和朗
    (公社)日本医学放射線学会, Feb. 2010, 日本医学放射線学会学術集会抄録集, 69回, S370 - S370, Japanese

  • Particle-Beam Radiation Therapy for Skull Base Chordomas: A Retrospective Study
    D. Miyawaki, Y. Demizu, K. Terashima, M. Mima, O. Fujii, Y. Niwa, K. Yoshida, H. Nishimura, R. Sasaki, M. Murakami
    2010, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78(3) (3), S613 - S613, English
    Summary international conference

  • Radiotherapy for Elderly Patients with Cervical Cancer
    K. Yoshida, H. Nishimura, D. Miyawaki, T. Kawabe, Y. Okamoto, K. Nakabayashi, S. Yoshida, R. Sasaki, K. Sugimura
    2010, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78(3) (3), S407 - S408, English
    Summary international conference

  • Vitamin K2 derived compounds induce growth inhibition in radioresistant cancer cells
    H.Amalia, R.Sasaki, Y.Suzuki, Y.Demizu, T.Bito, H.Nishimura, Y.Okamoto, K.Yoshida, D.Miyawaki, T.Kawabe, Y.Mizushina, K.Sugimura
    2010, Kobe J. Med. Sci., 2(56) (56), E38-E49

  • 前立腺癌放射線治療におけるKv-CBCTを用いたorgan motionの検討
    川村 哲朗, 村上 直基, 岡村 佳明, 西村 英輝, 井上 省三, 宮脇 大輔, 佐々木 良平, 土師 守
    加古川市民病院, Jan. 2010, 加古川市民病院誌, (10) (10), 27 - 29, Japanese

  • Particle therapy for mucosal malignant melanoma of the head and neck: a retrospective study
    D. Miyawaki, M. Murakami, Y. Demizu, M. Mima, K. Terashima, T. Arimura, Y. Niwa, R. Sasaki, K. Sugimura, Y. Hishikawa
    Sep. 2009, EJC SUPPLEMENTS, 7(2) (2), 477 - 477, English
    Summary international conference

  • Treatment outcomes for squamous cell carcinoma of the external auditory canal and middle ear
    K. Yoshida, M. Nakabayashi, R. Sasaki, H. Nishimura, Y. Okamoto, T. Kawabe, S. Hasegawa, N. Otsuki, K. Nibu, K. Sugimura
    Sep. 2009, EJC SUPPLEMENTS, 7(2) (2), 488 - 488, English
    Summary international conference

  • コ・メディカル教育 6大学連携オンコロジーチーム養成プランでのがん専門薬剤師養成コースの活動と現状
    西田 升三, 平井 みどり, 門林 宗男, 福岡 正博, 中川 和彦, 西村 恭昌, 平川 弘聖, 日野 雅之, 工藤 新三, 仲田 文造, 細野 雅子, 松井 徳造, 田中 京子, 高辻 功一, 丹生 健一, 佐々木 良平, 西村 善博, 南 博信, 中野 孝司, 廣田 省三, 長谷川 誠紀, 村川 和重, 一瀬 理加, 鈴木 志津枝, 安藤 悦子
    (一社)日本癌治療学会, Sep. 2009, 日本癌治療学会誌, 44(2) (2), 332 - 332, Japanese

  • HPV-DNA検出による中咽頭癌の化学放射線療法感受性予測
    太田 陽介, 鍬塚 葉子, 原田 文, 藤井 收, 辻野 佳世子, 副島 俊典, 小松 弘和, 平山 裕次, 岩江 信法, 大林 千穂, 須藤 保, 佐々木 良平
    (一社)日本癌治療学会, Sep. 2009, 日本癌治療学会誌, 44(2) (2), 516 - 516, Japanese

  • Yuko Kumamoto-Yonezawa, Ryohei Sasaki, Yosuke Ota, Yoko Suzuki, Shoji Fukushima, Takahiko Hada, Keisuke Uryu, Kazuro Sugimura, Hiromi Yoshida, Yoshiyuki Mizushina
    May 2009, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1790(5) (5), 339 - 346, English

  • 口腔悪性腫瘍に対する粒子線治療成績
    出水 祐介, 村上 昌雄, 宮脇 大輔, 寺嶋 千貴, 有村 健, 丹羽 康江, 森本 浩一, 佐々木 良平, 菱川 良夫
    (一社)日本頭頸部癌学会, May 2009, 頭頸部癌, 35(2) (2), 79 - 79, Japanese

  • ハイリスクHPV由来の中咽頭癌は(日本人においても)集学的治療による治癒率が高いのか?
    太田 陽介, 鍬塚 葉子, 森木 健生, 原田 文, 藤井 收, 辻野 佳世子, 副島 俊典, 小松 弘和, 平山 裕次, 岩江 信法, 大林 千穂, 須藤 保, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2009, 頭頸部癌, 35(2) (2), 97 - 97, Japanese

  • ホウレンソウ糖脂質画分の癌細胞増殖抑制と放射線増感効果の検討
    松井 由樹, 佐々木 良平, 鈴木 陽子, 米澤 裕子, 羽田 圭一郎, 前田 尚輝, 水品 善之, 吉田 弘美
    (公社)日本栄養・食糧学会, May 2009, 日本栄養・食糧学会大会講演要旨集, 63回, 159 - 159, Japanese

  • HCCに対する粒子線治療施行後Bilomaを形成した1例
    小松 昇平, 村上 昌雄, 宮脇 大輔, 小田 康江, 西村 英輝, 佐々木 良平, 香川 一史, 菱川 良夫, 福本 巧, 具 英成
    (公社)日本医学放射線学会, Apr. 2009, Japanese Journal of Radiology, 27(Suppl.) (Suppl.), 48 - 48, Japanese

  • 転移性骨腫瘍に対する粒子線治療の初期経験
    橋本 彩, 村上 昌雄, 宮脇 大輔, 小田 康江, 出水 祐介, 菱川 良夫, 太田 陽介, 佐々木 良平
    (公社)日本医学放射線学会, Apr. 2009, Japanese Journal of Radiology, 27(Suppl.) (Suppl.), 58 - 58, Japanese

  • 転移性腫瘍に対する少分割粒子線治療の試み
    出水 祐介, 村上 昌雄, 橋本 彩, 宮脇 大輔, 小田 康江, 菱川 良夫, 太田 陽介, 佐々木 良平
    (公社)日本医学放射線学会, Apr. 2009, Japanese Journal of Radiology, 27(Suppl.) (Suppl.), 58 - 58, Japanese

  • 【がん患者の放射線療法と看護】 知っておきたい放射線治療の方法 高精度放射線治療 IMRT(強度変調放射線治療)を中心に
    Sasaki Ryohei, Nishimura Hideki
    (株)南江堂, Mar. 2009, がん看護, 14巻, 3号, pp. 356-360(3) (3), 356 - 360, Japanese
    Introduction scientific journal

  • 転移性肝腫瘍に対する粒子線治療
    寺嶋 千貴, 村上 昌雄, 宮脇 大輔, 有村 健, 出水 祐介, 丹羽 康江, 菱川 良夫, 佐々木 良平, 杉村 和朗
    (公社)日本医学放射線学会, Feb. 2009, 日本医学放射線学会学術集会抄録集, 68回, S220 - S220, Japanese

  • Prognostic Significance of HPV infection and P16 Expression: A Strategy for Organ Preservation in Oropharyngeal Squamous Cell Carcinoma
    Y. Ota, T. Soejima, K. Tsujino, O. Fujii, S. Iwae, T. Sudo, C. Ohbayashi, R. Sasaki
    2009, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75(3) (3), S409 - S410, English
    Summary international conference

  • Radiation Therapy in Patients with Implanted Cardiac Pacemakers and Implantable Cardio-defibrillators: A Prospective Survey in Japan
    T. Soejima, E. Yoden, Y. Nishimura, S. Ono, A. Yoshida, H. Fukuda, N. Fukuhara, R. Sasaki, K. Tsujino, Y. Norihisa
    2009, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75(3) (3), S500 - S500, English
    Summary international conference

  • Treatment Outcomes of Squamous Cell Carcinoma of External Auditory Canal and Middle Ear
    K. Yoshida, R. Sasaki, M. Nakabayashi, H. Nishimura, Y. Okamoto, T. Kawabe, S. Hasegawa, N. Otsuki, K. Nibu, K. Sugimura
    2009, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75(3) (3), S424 - S424, English
    Summary international conference

  • Radiotherapy for Locally Advanced Hypopharyngeal Carcinoma - A Comparison between Definitive (Chemo-) Radiotherapy and Laryngectomy followed by Postoperative Radiotherapy
    H. Nishimura, R. Sasaki, Y. Okamoto, K. Yoshida, T. Kawabe, K. Nibu, N. Ohtsuki, M. Saitoh, T. Soejima, K. Sugimura
    2009, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75(3) (3), S418 - S418, English
    Summary international conference

  • がんプロフェッショナル養成プランについて 6大学連携オンコロジーチーム養成プラン
    仲田 文造, 日野 雅之, 中川 和彦, 西村 恭昌, 西田 升三, 中野 孝司, 廣田 省三, 南 博信, 佐々木 良平, 田中 京子, 林田 裕美, 鈴木 志津枝
    (一社)日本癌治療学会, Oct. 2008, 日本癌治療学会誌, 43(2) (2), 275 - 275, Japanese

  • 巨大肝癌に対して2回の陽子線治療で制御できた1例
    宮脇 大輔, 村上 昌雄, 小松 昇平, 一宮 結加子, 小田 康江, 西村 英輝, 佐々木 良平, 香川 一史, 菱川 良夫, 杉村 和朗
    (公社)日本医学放射線学会, Apr. 2008, Radiation Medicine, 26(Suppl.I) (Suppl.I), 52 - 52, Japanese

  • ビタミンK群のDNAポリメラーゼ阻害活性とヒト癌細胞増殖抑制活性
    西田 真之, 米澤 裕子, 佐々木 良平, 鈴木 陽子, 杉村 和朗, 水品 善之, 吉田 弘美
    (公社)日本栄養・食糧学会, Apr. 2008, 日本栄養・食糧学会大会講演要旨集, 62回, 149 - 149, Japanese

  • Particle therapy for adenoid cystic carcinoma of the head and neck: A retrospective study
    Y. Demizu, M. Murakami, D. Miyawaki, Y. Oda, R. Sasaki, Y. Hishikawa
    2008, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 72(1) (1), S404 - S405, English
    Summary international conference

  • 術前CRTにて腫瘍縮小を得て、ISR施行した直腸癌の一例
    高瀬 至郎, 今西 達也, 中村 哲, 岩谷 慶照, 鈴木 知志, 金 英植, 神垣 隆, 黒田 大介, 黒田 嘉和, 岡本 欣晃, 佐々木 良平, 吉田 賢史, 大林 千穂
    日本臨床外科学会, Nov. 2007, 日本臨床外科学会雑誌, 68(増刊) (増刊), 792 - 792, Japanese

  • Confirmation of proton beam by positron emission tomography apparatus in patients with prostate cancer
    M. Shimizu, R. Sasaki, D. Miyawaki, H. Nishimura, Y. Demizu, T. Akagi, D. Suga, M. Murakami, K. Sugimura, Y. Hishikawa
    Sep. 2007, EJC SUPPLEMENTS, 5(4) (4), 296 - 297, English
    Summary international conference

  • Impact of nuclear factor kappa B activity for local tumor controllability by radiotherapy in patients with T1/T2N0 laryngeal cancer
    K. Yoshida, R. Sasaki, Y. Okamoto, Y. Ejima, H. Nishimura, Y. Ota, M. Saitoh, N. Otsuki, K. Nibu, K. Sugimura
    Sep. 2007, EJC SUPPLEMENTS, 5(4) (4), 336 - 337, English
    Summary international conference

  • Subacute central nervus system morbidity after proton therapy and carbon ion therapy against head and neck cancers and skull base tumors: impact of sequential evaluation MR imaging
    M. Murakami, R. Sasaki, H. Nishimura, Y. Demizu, Y. Oda, K. Sugimura, Y. Hishikawa
    Sep. 2007, EJC SUPPLEMENTS, 5(4) (4), 334 - 335, English
    Summary international conference

  • A novel strategy to overcome rdioresistance: selective inhibition of mitochondrial DNA polymerase gamma by vitamin K compounds
    R. Sasaki, Y. Suzuki, Y. Ota, Y. Yonezawa, P. Huang, K. Yoshida, H. Nishimura, Y. Okamoto, K. Sugimura, Y. Mizushina
    Sep. 2007, EJC SUPPLEMENTS, 5(4) (4), 123 - 123, English
    Summary international conference

  • Proton radiotherapy for patients with prostate cancer - in the Hyogo Ion Beam Medical Center (HIBMC) experience
    M. Murakami, D. Miyawaki, Y. Demizu, H. Mayahara, Y. Oda, H. Nishimura, R. Sasaki, Y. Hishikawa
    Sep. 2007, EJC SUPPLEMENTS, 5(4) (4), 294 - 294, English
    Summary international conference

  • 下咽頭癌T1、T2症例の治療成績
    大月 直樹, 斎藤 幹, 佐々木 良平, 岡本 欣晃, 丹生 健一
    (一社)日本癌治療学会, Sep. 2007, 日本癌治療学会誌, 42(2) (2), 799 - 799, Japanese

  • 【Image-guided Radiotherapy-現状と将来】FDG-PET世代の肺癌・食道癌放射線治療
    佐々木 良平, 岡本 欣晃, 杉村 和朗
    金原出版(株), Aug. 2007, 臨床放射線, 52(8) (8), 985 - 991, Japanese

  • 当院におけるI-II期下咽頭癌に対する根治的放射線治療の遡及的検討
    西村 英輝, 佐々木 良平, 岡本 欣晃, 太田 陽介, 吉田 賢史, 杉村 和朗, 丹生 健一, 大月 直樹, 斉藤 幹, 副島 俊典
    (一社)日本頭頸部癌学会, May 2007, 頭頸部癌, 33(2) (2), 124 - 124, Japanese

  • 頭頸部癌進行例に対する根治手術後化学放射線療法の検討
    大月 直樹, 齋藤 幹, 谷本 均, 長谷川 信吾, 伊集院 隆宏, 土井 清司, 平山 裕次, 丹生 健一, 佐々木 良平, 岡本 欣晃
    (一社)日本頭頸部癌学会, May 2007, 頭頸部癌, 33(2) (2), 145 - 145, Japanese

  • 放射線腫瘍医の入局状況.
    永田靖, 手島昭樹, 中村和正, 大西洋, 荻野尚, 中野隆, 福田晴行, 佐々木良平, 芦野靖夫, 西尾禎治, 岡崎篤, 佐藤守男
    2007, JASTRO newsletter, 84(2) (2), 32 - 33

  • 【遠隔画像診断の将来展望】 遠隔画像診断 NPOによる運営
    FUJII MASAHIKO, Taniguchi Takanori, OHNO YOSHIHARU, SASAKI RYOHEI, Sugimura Kazuro
    産業開発機構(株), Apr. 2006, 映像情報Medical, 38巻, 4号, pp. 469-472(4) (4), 469 - 472, Japanese
    Introduction scientific journal

  • 神戸大学におけるNPO方式による遠隔画像診断について
    FUJII, Masahiko, TANIGUCHI, Takanori, OHNO, Yoshiharu, SASAKI, Ryohei, SUGIMURA, Kazuro, 時本康紘, 菅野悦正, 太田尚志
    (公社)日本医学放射線学会, Feb. 2006, 日本医学放射線学会雑誌, 65回抄録集, pp.S302-S303, S302 - S303, Japanese
    Introduction scientific journal

  • Radiation therapy in patients with cardiac pacemakers and implantable cardio-defibrillators: a survey of patterns of practice among radiation oncology in Japan
    T. Soejima, E. Yoden, K. Tsujino, O. Fujil, Y. Ichimiya, Y. Nishimura, H. Fukuda, R. Sasaki, A. Yoshida
    Oct. 2005, EJC SUPPLEMENTS, 3(2) (2), 408 - 408, English
    Summary international conference

  • Aberrant cytoplasmic BCL10 expression reflects advanced disease in patients with mucosa-associated lymphoid tissue lymphoma of ocular adnexa
    Y. Ejima, R. Sasaki, Y. Okamoto, T. Maruta, A. Azumi, Y. Hayashi, D. Miyawaki, Y. Ota, T. Soejima, K. Sugimura
    Oct. 2005, EJC SUPPLEMENTS, 3(2) (2), 284 - 284, English
    Summary international conference

  • FDG-PETによるSUV(standardized uptake value)は非小細胞肺癌の結果を予測する(SUV by FDG-PET Predicts Outcome of Non-Small-Cell Lung Cancer)
    佐々木 良平, Komaki Ritsuko, Macapinlac Homer, Allen Pamela, Podoloff Donald, Cox James D
    (公社)日本放射線腫瘍学会, Oct. 2004, 日本放射線腫瘍学会誌, 16(Suppl.1) (Suppl.1), 107 - 107, English

  • Double strand breaks induced by carbon ion irradiation in prostate cancer cells
    H Nishimura, R Sasaki, Y Ejima, K Ando, T Soejima, K Sugimura
    Nov. 2002, RADIOLOGY, 225, 176 - 176, English
    Summary international conference

  • 重粒子線照射後の前立腺癌細胞におけるDNA二本鎖切断と修復に関する基礎的研究
    西村 英輝, 佐々木 良平, 江島 泰生, 副島 俊典, 余田 栄作, 出水 祐介, 河邊 哲也, 杉村 和朗, 安藤 興一, 古澤 佳也
    (公社)日本医学放射線学会, Oct. 2002, 日本医学放射線学会雑誌, 62(12) (12), 719 - 719, Japanese

  • 中咽頭側壁型扁平上皮癌症例の検討
    志水 賢一郎, 丹生 健一, 毛利 光宏, 井上 博之, 土井 清司, 副島 俊典, 佐々木 良平, 牧野 邦彦
    (一社)日本頭頸部癌学会, May 2002, 頭頸部腫瘍, 28(2) (2), 447 - 447, Japanese

  • 放射線療法を施行した眼球原発悪性リンパ腫の1例
    北村 恵理, 余田 栄作, 西村 英輝, 江島 泰生, 佐々木 良平, 山田 和成, 副島 俊典, 杉村 和朗, 丸田 力
    (公社)日本医学放射線学会, Feb. 2002, 日本医学放射線学会雑誌, 62(2) (2), 98 - 98, Japanese

  • 放射線治療中におけるチェックリストパス導入の効果
    佐々木 博一, 庄 敏也, 佐野 剛士, 門脇 伸行, 川西 徹, 篠原 さおり, 大谷 捷生, 酒井 英郎, 増田 裕美子, 佐々木 良平, 山崎 恵子
    (一財)甲南病院, Dec. 2001, 甲南病院医学雑誌, 21, 72 - 72, Japanese

  • 血管肉腫に対する放射線治療と予後因子(第2報)
    佐々木 良平, 副島 俊典, 広田 佐栄子, 今城 吉成, 上紺屋 憲彦, 河辺 哲也, 村上 昌雄, 杉村 和朗
    (公社)日本放射線腫瘍学会, Oct. 2001, 日本放射線腫瘍学会誌, 13(Suppl.1) (Suppl.1), 109 - 109, Japanese

  • 急性白血病に対する予防的全脳照射後の脳病変
    副島 俊典, 江島 泰生, 西村 英輝, 佐々木 良平, 余田 栄作, 山田 和成, 杉村 和朗
    (公社)日本放射線腫瘍学会, Oct. 2001, 日本放射線腫瘍学会誌, 13(Suppl.1) (Suppl.1), 79 - 79, Japanese

  • 放射線肺臓炎の血清マーカー:KL-6,SP-D,SP-Aの比較と有用性
    佐々木 良平, 西村 英輝, 江島 泰生, 余田 栄作, 山田 和成, 副島 俊典, 杉村 和朗
    (公社)日本医学放射線学会, Oct. 2001, 日本医学放射線学会雑誌, 61(12) (12), 704 - 704, Japanese

  • 頸部放射線治療後の甲状腺機能低下(第2報)
    余田 栄作, 丸田 力, 副島 俊典, 西村 英輝, 佐々木 良平, 山田 和成, 杉村 和朗
    (公社)日本医学放射線学会, Feb. 2001, 日本医学放射線学会雑誌, 61(2) (2), S138 - S138, Japanese

  • 前立腺癌細胞に対する放射線・アデノウイルスp53遺伝子併用療法の検討
    佐々木 良平, 白川 利朗, 後藤 章暢, 松尾 雅文, 杉村 和朗
    (公社)日本医学放射線学会, Feb. 2001, 日本医学放射線学会雑誌, 61(2) (2), S201 - S201, Japanese

  • 当院におけるDICOM画像と電子放射線治療カルテを統合した放射線治療ネットワークシステム
    副島 俊典, 丸田 力, 山田 和成, 余田 栄作, 佐々木 良平, 西村 英輝, 杉村 和朗
    (公社)日本医学放射線学会, Feb. 2001, 日本医学放射線学会雑誌, 61(2) (2), S252 - S252, Japanese

  • 扁桃癌の治療法について
    志水 賢一郎, 牧野 邦彦, 大木本 和也, 前野 博昭, 魚住 真樹, 鳥山 満由, 天津 睦郎, 副島 俊典, 丸田 力, 佐々木 良平
    (一社)日本耳鼻咽喉科学会, Jan. 2001, 日本耳鼻咽喉科学会会報, 104(1増刊) (1増刊), 55 - 55, Japanese

  • I期II期非小細胞肺癌に対する放射線治療成績
    山田 和成, 副島 俊典, 丸田 力, 余田 栄作, 佐々木 良平, 西村 英輝, 小島 芳夫, 足立 秀治, 杉村 和朗
    (公社)日本医学放射線学会, Nov. 2000, 日本医学放射線学会雑誌, 60(13) (13), 772 - 772, Japanese

  • 膀胱癌に対する放射線療法及びp53遺伝子治療による併用療法の検討
    日向 信之, 白川 利朗, 佐々木 良平, 後藤 章暢, 和田 義孝, 藤澤 正人, 荒川 創一, 松尾 雅文, 守殿 貞夫
    日本癌学会, Sep. 2000, 日本癌学会総会記事, 59回, 63 - 64, Japanese

  • 抗癌剤抵抗性ヒト膀胱腫瘍に対するp53アデノウイルスベクターを用いた遺伝子治療の検討
    白川 利朗, 後藤 章暢, 佐々木 良平, 日向 信之, 和田 義孝, 藤澤 正人, 岡田 弘, 荒川 創一, 松尾 雅文, 守殿 貞夫
    日本癌学会, Sep. 2000, 日本癌学会総会記事, 59回, 407 - 407, Japanese

  • Adult murine brain に対する放射線照射後の病理組織学的検討 : Subependymal zone, 及び dentate gyrus における progenitor cell の apoptosis を中心に
    佐々木 良平, 杉村 和朗, 伊東 恭子, 松本 明
    01 Jun. 2000, Neuropathology : official journal the Japanese Society of Neuropathology, 20, 183 - 183, Japanese

  • 【呼吸器病の検査と治療】肺疾患 放射線肺臓炎の血清診断 血清KL-6,肺Surfactant protein D and A(SP-D and SP-A)測定の意義
    佐々木 良平, 杉村 和朗
    (株)エスアールエル, May 2000, SRL宝函, 23(4) (4), 210 - 215, Japanese

  • 上咽頭癌に対する化学放射線同時併用療法の初期治療経験
    副島 俊典, 丸田 力, 佐々木 良平, 太田 陽介, 河邊 哲也, 山田 和成, 杉村 和朗, 石田 春彦, 天津 睦郎
    (一社)日本頭頸部癌学会, May 2000, 頭頸部腫瘍, 26(2) (2), 293 - 293, Japanese

  • 上咽頭癌に対する定位的放射線照射
    河邊 哲也, 副島 俊典, 丸田 力, 太田 陽介, 佐々木 良平, 山田 和成, 杉村 和朗, 石田 春彦, 天津 睦郎, 浜崎 昌丈
    (一社)日本頭頸部癌学会, May 2000, 頭頸部腫瘍, 26(2) (2), 295 - 295, Japanese

  • 扁桃癌の治療法について
    牧野 邦彦, 大木本 和也, 志水 賢一郎, 前野 博昭, 魚住 真樹, 鳥山 満由, 天津 睦郎, 副島 俊典, 丸田 力, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2000, 頭頸部腫瘍, 26(2) (2), 352 - 352, Japanese

  • 頭頸部腫瘍に対する定位的放射線照射
    河邊 哲也, 副島 俊典, 丸田 力, 太田 陽介, 佐々木 良平, 山田 和成, 杉村 和朗, 江原 一雅, 玉木 紀彦, 浜崎 昌丈
    (公社)日本医学放射線学会, Mar. 2000, 日本医学放射線学会雑誌, 60(4) (4), 223 - 223, Japanese

  • 抗癌剤抵抗性ヒト膀胱腫瘍に対するp53アデノウイルスベクターを用いた遺伝子治療の検討
    白川 利朗, 後藤 章暢, 佐々木 良平, 日向 信之, 和田 義孝, 藤澤 正人, 岡田 弘, 荒川 創一, 内藤 誠二, 松尾 雅文
    (一社)日本泌尿器科学会, Mar. 2000, 日本泌尿器科学会雑誌, 91(3) (3), 250 - 250, Japanese

  • 眼窩初発低悪性度IE期悪性リンパ腫の放射線治療成績
    丸田 力, 副島 俊典, 山田 和成, 佐々木 良平, 河邊 哲也, 太田 陽介, 杉村 和朗, 安積 淳
    (公社)日本医学放射線学会, Feb. 2000, 日本医学放射線学会雑誌, 60(2) (2), S117 - S117, Japanese

  • Adult murine brainに対する放射線照射後の病理組織学的検討 Dentate gyrusにおけるprogenitor cellのapoptosisを中心に
    佐々木 良平, 太田 陽介, 河邊 哲也, 山田 和成, 丸田 力, 副島 俊典, 杉村 和朗, 松本 明
    (公社)日本医学放射線学会, Feb. 2000, 日本医学放射線学会雑誌, 60(2) (2), S273 - S273, Japanese

  • 頭頸部腫瘍に対する定位的放射線照射
    河邊 哲也, 副島 俊典, 丸田 力, 太田 陽介, 佐々木 良平, 山田 和成, 杉村 和朗, 江原 一雅, 玉木 紀彦, 浜崎 昌丈
    (公社)日本医学放射線学会, Feb. 2000, 日本医学放射線学会雑誌, 60(2) (2), S277 - S277, Japanese

  • ぼうこう癌に対する放射線療法およびp53遺伝子治療による併用療法の検討
    日向信之, 白川利朗, 佐々木良平, 後藤章暢, 和田義孝, 藤沢正人, 荒川創一, 松尾雅文, 守殿貞夫
    2000, Japanese Journal of Cancer Research, 91(Supplement (Sept)) (Supplement (Sept))

  • 抗癌剤抵抗性ヒトぼうこう腫ように対するp53アデノウイルスベクターを用いた遺伝子治療の検討
    白川利朗, 後藤章暢, 佐々木良平, 日向信之, 和田義孝, 藤沢正人, 岡田弘, 荒川創一, 守殿貞夫
    2000, Japanese Journal of Cancer Research, 91(Supplement (Sept)) (Supplement (Sept))

  • 頭頸部原発Extramedullary Plasmacytomaの放射線療法
    太田 陽介, 副島 俊典, 丸田 力, 佐々木 良平, 杉村 和朗, 石田 春彦, 天津 睦郎, 児玉 明久, 岩間 祐基
    (公社)日本医学放射線学会, Jan. 2000, 日本医学放射線学会雑誌, 60(1) (1), 51 - 51, Japanese

  • Stage I,II声門癌に対する放射線治療成績
    江島 泰生, 副島 俊典, 安藤 正憲, 工藤 剛史, 牛尾 啓二, 雲井 一夫, 太田 陽介, 佐々木 良平, 丸田 力, 杉村 和朗
    (公社)日本放射線腫瘍学会, Nov. 1999, 日本放射線腫瘍学会誌, 11(Suppl.1) (Suppl.1), 186 - 186, Japanese

  • 頭頸部原発Extramedullary Plasmacytomaの放射線療法
    太田 陽介, 副島 俊典, 佐々木 良平, 丸田 力, 杉村 和朗, 石田 春彦, 天津 睦郎, 児玉 明久, 泉山 一隆, 岩間 祐基
    (公社)日本放射線腫瘍学会, Nov. 1999, 日本放射線腫瘍学会誌, 11(Suppl.1) (Suppl.1), 267 - 267, Japanese

  • 胸部放射線照射における血清KL-6,血清肺サーファクタントA,D測定の意義
    佐々木 良平, 太田 陽介, 丸田 力, 副島 俊典, 山田 和成, 繪野 幸二, 江島 泰生, 牛尾 啓二, 杉村 和朗
    (公社)日本放射線腫瘍学会, Nov. 1999, 日本放射線腫瘍学会誌, 11(Suppl.1) (Suppl.1), 288 - 288, Japanese

  • 頭皮原発悪性血管内皮細胞腫に対する放射線治療成績 Interleukin-2局注併用の意義
    佐々木 良平, 副島 俊典, 丸田 力, 太田 陽介, 杉村 和朗, 市橋 正光, 児玉 明久, 金岡 徳芳, 辻野 佳世子, 広田 佐栄子
    (一社)日本癌治療学会, Oct. 1999, 日本癌治療学会誌, 34(2) (2), 412 - 412, Japanese

  • 河野 康一, 村上 昌雄, 黒田 康正, 岡本 欣晃, 溝脇 尚志, 余田 栄作, 佐々木 良平, 赤坂 好宣, 中島 俊文
    (公社)日本医学放射線学会, Oct. 1999, 日本医学放射線学会雑誌, 59(12) (12), 689 - 697, Japanese

  • 【アンギオを中心とした膵疾患読影のポイント】通常の膵管癌及び鑑別を要する膵炎 Hypervascular Tumorとして描出された膵頭部癌の1例
    佐々木 良平, 赤坂 好宣, 左野 明, 黒田 康正
    バイエル薬品(株), Jun. 1999, 日独医報, 44(1) (1), 62 - 63, Japanese

  • 【アンギオを中心とした膵疾患読影のポイント】稀な癌(腺房細胞癌,腺扁平上皮癌,未分化癌等) Hypovascular Patternを呈した膵尾部Aciner Cell Carcinomaの1例
    佐々木 良平, 廣田 省三, 松本 真一, 佐古 正雄, 西田 道弘, 杉村 和朗
    バイエル薬品(株), Jun. 1999, 日独医報, 44(1) (1), 103 - 105, Japanese

  • 小児血液疾患に対するTBIの治療経験
    児玉 明久, 丸田 力, 佐々木 良平, 太田 陽介, 小阪 嘉之
    (公社)日本医学放射線学会, Feb. 1999, 日本医学放射線学会雑誌, 59(2) (2), S124 - S124, Japanese

  • 頸部放射線治療後の甲状腺機能低下
    丸田 力, 太田 陽介, 佐々木 良平, 辻野 佳世子, 児玉 明久
    (公社)日本医学放射線学会, Feb. 1999, 日本医学放射線学会雑誌, 59(2) (2), S117 - S117, Japanese

  • 頭皮悪性血管内皮細胞腫に対する放射線治療の意義
    佐々木 良平, 金岡 徳芳, 丸田 力, 太田 陽介, 児玉 明久, 市橋 正光
    (公社)日本医学放射線学会, Feb. 1999, 日本医学放射線学会雑誌, 59(2) (2), S234 - S234, Japanese

  • 肺癌脳転移に対する全脳照射
    太田 陽介, 佐々木 良平, 丸田 力, 児玉 明久, 保坂 加代, 山田 和成, 酒井 英郎, 絵野 幸二, 西田 道弘
    (公社)日本医学放射線学会, Feb. 1999, 日本医学放射線学会雑誌, 59(2) (2), S233 - S234, Japanese

  • 乳癌骨転移の初回放射線治療における予後因子の検討
    余田 栄作, 村上 昌雄, 黒田 康正, 河野 康一, 佐々木 良平
    (公社)日本医学放射線学会, Jan. 1999, 日本医学放射線学会雑誌, 59(1) (1), 27 - 33, Japanese

  • 放射線治療が著効した局所進行外陰癌の1例
    太田 陽介, 佐々木 良平, 丸田 力, 辻野 佳世子, 児玉 明久, 河野 通雄, 竹内 聡, 本山 覚, 丸尾 猛
    (公社)日本医学放射線学会, Oct. 1998, 日本医学放射線学会雑誌, 58(12) (12), 718 - 718, Japanese

  • 膵頭部周囲に腫瘤を形成した結核性リンパ節炎
    前谷 洋爾, 佐々木 良平, 余田 栄作, 左野 明
    バイエル薬品(株), Aug. 1998, 日独医報, 43(2) (2), 310 - 311, Japanese

  • 非小細胞肺癌の術後局所再発に対する放射線治療成績
    河野 康一, 村上 昌雄, 佐々木 良平
    (公社)日本医学放射線学会, Jan. 1998, 日本医学放射線学会雑誌, 58(1) (1), 18 - 24, Japanese

  • 集学的治療を行ったAskin tumorの1例
    佐々木 良平
    (公社)日本医学放射線学会, Sep. 1997, 日本医学放射線学会雑誌, 57(10) (10), S328 - S329, Japanese

  • Real-prep法を用いた肝腫瘍に対する三相性CTの検討
    佐々木 良平
    (公社)日本医学放射線学会, Aug. 1997, 日本医学放射線学会雑誌, 57(9) (9), 619 - 619, Japanese

  • 脾Peliosisが疑われた1例
    佐々木 良平
    (公社)日本医学放射線学会, Jun. 1997, 日本医学放射線学会雑誌, 57(7) (7), 456 - 456, Japanese

  • Experience in Treatment of Patients with Locally advanced or Recurrent Breast Cancer: Intraarterial infusion chemotherapy combined with radiotherapy
    Masao Murakami, Eisaku Yoden, Koichi Kono, Yoshiaki Okamoto, Yoji Maetani, Heitetu Sai, Katsuhiro Kobayashi, Ryohei Sasaki, Nobukatu Kazawa, Akira Sano, Yasumasa Kuroda
    日本医学放射線学会, 1997, Nippon Acta Radiologica, 57(4) (4), 189 - 194, Japanese

  • 非小細胞肺癌術後局所再発例に対する放射線治療 : 予後因子の検討
    河野 康一, 村上 昌雄, 佐々木 良平, 余田 栄作, 黒田 康正
    日本肺癌学会, 30 Sep. 1996, 肺癌, 36(5) (5), 589 - 589, Japanese

  • 肺癌・上大静脈症候群の放射線治療成績
    佐々木 良平
    (NPO)日本肺癌学会, Sep. 1996, 肺癌, 36(5) (5), 674 - 674, Japanese

  • 術前診断が困難であった混合型肝細胞癌,胆管細胞癌の1例
    佐々木 良平, 余田 栄作, 河野 康一
    バイエル薬品(株), Jul. 1996, 日独医報, 41(2) (2), 344 - 345, Japanese

  • 上大静脈症候群を来たした肺癌に対する放射線治療成績
    佐々木 良平
    (公社)日本医学放射線学会, Feb. 1996, 日本医学放射線学会雑誌, 56(2) (2), 187 - 187, Japanese

  • Local Area Network for Management of Radiation Oncology : with Software Named "TROG net" Newly-developed
    MURAKAMI MASAO, YODEN EISAKU, KONO KOUICHI, TACHIIRI SEIJI, SASAKI RYOHEI, SATO KOICHI, KURODA YASUMASA
    01 Oct. 1995, 日本放射線腫瘍学会誌学術大会報文集, 17(1) (1), 250 - 250, Japanese

  • 下垂体腺腫の放射線治療効果における画像および内分泌学的評価
    佐々木 良平
    (公社)日本放射線腫瘍学会, Oct. 1995, 日本放射線腫瘍学会誌, 7(Suppl.1) (Suppl.1), 177 - 177, Japanese

  • 小細胞肺癌脳転移照射後に脳再発を来した15例の検討 : 癌性胸膜炎2, 脳転移
    村上 昌雄, 黒田 康正, 森 岳樹, 余田 栄作, 立入 誠司, 佐々木 良平, 左野 明, 郡 義明, 種田 和清
    日本肺癌学会, 01 Sep. 1995, 肺癌, 35(5) (5), 643 - 643, Japanese

  • 下垂体腺腫の放射線治療成績
    佐々木 良平
    (公社)日本医学放射線学会, Feb. 1995, 日本医学放射線学会雑誌, 55(2) (2), S145 - S145, Japanese

  • 小細胞肺癌脳転移の予後因子の検討 : 再発肺癌に対するストラテジー
    森 岳樹, 村上 昌雄, 金岡 徳芳, 岡田 知久, 崔 〓哲, 前谷 洋爾, 立入 誠司, 佐々木 良平, 野間 恵之, 左野 明, 黒田 康正
    日本肺癌学会, 10 Oct. 1994, 肺癌, 34(5) (5), 623 - 623, Japanese

  • III期非小細胞肺癌に対するCDDP-BAI・放射線同時併用療法の治療成績 : BAI非併用群との比較 : 進行肺癌の治療(1)
    村上 昌雄, 左野 明, 金岡 徳芳, 岡田 知久, 森 岳樹, 崔 〓哲, 前谷 洋爾, 立入 誠司, 佐々木 良平, 野間 恵之, 黒田 康正
    日本肺癌学会, 10 Oct. 1994, 肺癌, 34(5) (5), 660 - 660, Japanese

  • 放射線治療を行った限局型肺小細胞癌の治療成績 : 多変量解析による検討を加えて : 治療
    金岡 徳芳, 村上 昌雄, 岡田 知久, 森 岳樹, 崔 〓哲, 前谷 洋爾, 立入 誠司, 佐々木 良平, 野間 恵之, 左野 明, 黒田 康正
    日本肺癌学会, 10 Oct. 1994, 肺癌, 34(5) (5), 760 - 760, Japanese

  • 人体の体格と低周波Gz振動特性との関係
    佐々木良平, 岩根正昭, 原田正智, 小野幹雄, 緒方昭二, 万木良平
    航空医学実験隊, Sep. 1970, 航空医学実験隊報告, 11(2) (2), 148 - 153, Japanese

  • 耐水服装着時の拇指皮膚温の変化
    山崎由久, 黒田勲, 佐々木良平
    (一社)日本防衛衛生学会, Jul. 1970, 防衛衛生, 17(7) (7), 207 - 208, Japanese

  • 耐寒耐水服に関する研究
    黒田勲, 大原直樹, 山崎由久, 佐々木良平, 徳留末芳, 矢野清江, 石川賢吉
    航空医学実験隊, Jun. 1970, 航空医学実験隊報告, 11(1) (1), 16 - 23, Japanese

  • 人体の体格と低周波G2振動特性
    佐々木良平, 岩崎正昭, 原田正智, 小野幹雄, 万木良平
    日本宇宙航空環境医学会, Jun. 1970, 宇宙航空環境医学, 7(2) (2), 49 - 49, Japanese

■ Books And Other Publications
  • 眼科検査ガイド 第2版 / 超音波・放射線・画像診断 ５）PET, SPECT, ガリウムシンチ
    西川遼, Sasaki Ryohei
    Joint work, 文光堂, Sep. 2016, Japanese
    Scholarly book

  • 外来患者をサポートする がん薬物療法マネジメントブック / 第2章 がん薬物療法のマネジメントに役立つ情報と活用術、３．検査所見 2)異常所見画像
    宮脇大輔, 清水康之, Sasaki Ryohei
    Joint work, 株式会社じほう, Sep. 2016, Japanese
    Scholarly book

  • 耳鼻咽喉科・頭頸部外科研修ノート 改訂第2版 / 第7章 放射線治療
    Sasaki Ryohei
    Joint work, 診断と治療社, 2016, Japanese
    Scholarly book

  • Radiotherapy / New paradigm of radiotherapy for bone metastasis
    YasuoEjima, TakeakiIshihara, DaisukeMiyawaki, KenichiroKakutani, KotaroNishida, JunichiroInoue, YoshitadaSakai, TianyuanWang, Sasaki Ryohei
    Joint work, INTECH, 2016, English
    Scholarly book

  • Non-woven Fabrics / Medical Application of Nonwoven Fabrics: Intra-abdominal Spacers for Particle Therapy.
    Sasaki Ryohei, HiroakiAkasaka, YusukeDemizu, SachikoInubushi, TianyuanWang, TakumiFukumoto
    Others, INTECH, 2016, English
    Scholarly book

  • 頭頸部がんの化学放射線療法 : カラーアトラス : 目で見て学ぶ! : 多職種チームで実践する
    丹生 健一, 佐々木 良平, 大月 直樹, 大田 史江
    日本看護協会出版会, 2015, Japanese, ISBN: 9784818018983

  • 決定版チームで取り組む乳がん放射線療法
    佐々木 良平, 淡河 恵津世, 唐澤 久美子
    メディカル教育研究社, 2013, Japanese, ISBN: 9784990731809

  • チームで取り組む乳がん放射線療法
    Sasaki Ryohei
    Supervisor, メディカル教育研究社, 2013, Japanese
    Textbook

  • 最新放射線医学 / 放射線医学総論 第8巻7章 放射線治療における医療事故防止
    Yoshida Kenji, Sasaki Ryohei
    Others, 金芳堂, 2012, Japanese
    Textbook

  • 最新放射線医学 / 放射線医学総論 第8巻2章 放射線治療計画
    Sasaki Ryohei
    Others, 金芳堂, 2012, Japanese
    Textbook

  • 最新放射線医学 / 放射線医学総論 第8巻19章 皮膚・軟部・骨疾患の放射線治療
    Sasaki Ryohei, Bito Toshinori
    Others, 金芳堂, 2012, Japanese
    Textbook

  • カラーアトラス 目で見て学ぶ 放射線療法の有害反応 多職種チームで実践する治療と患者支援 / 放射線療法の理解 / 【放射線療法と併用療法の理解】放射線療法の理解
    Sasaki Ryohei, Nishimura Hideki, Miyawaki Daisuke
    Joint work, 日本看護協会出版会, Feb. 2011, Japanese
    Textbook

  • 目で見て学ぶ放射線療法の有害反応 : 多職種チームで実践する治療と患者支援 : カラーアトラス
    丹生 健一, 佐々木 良平, 鈴木 志津枝
    日本看護協会出版会, 2011, Japanese, ISBN: 9784818015944

  • 最新放射線医学 / 放射線医学総論 第1巻14章 放射線物理学
    Sasaki Ryohei
    Others, 金芳堂, 2011, Japanese
    Textbook

  • Cervical Cancer / Cervical cancer treatment in aging women
    Yoshida Kohsuke, Sasaki Ryohei, Miyawaki Daisuke, Sugimura Kazuro
    Others, INTECH, 2011, English
    Textbook

  • がん・放射線療法2010別冊 / 下垂体腺腫
    Sasaki Ryohei
    Joint work, 篠原出版新社, 2010, Japanese
    General book

  • がん・放射線療法2010 / 下垂体腺腫
    Sasaki Ryohei
    Joint work, 篠原出版新社, 2010, Japanese
    Textbook

  • 放射線治療を受ける癌患者の看護ケア / 【放射線照射】 放射線治療は、どのような流れで進められるのでしょうか？
    Sasaki Ryohei
    Joint work, 日本看護協会出版社, May 2008, Japanese
    Textbook

  • 放射線治療を受ける癌患者の看護ケア / 【放射線照射】 放射線治療の目的にはどのようなものがありますか？
    Sasaki Ryohei
    Joint work, 日本看護協会出版社, May 2008, Japanese
    Textbook

  • 放射線治療を受ける癌患者の看護ケア / 【放射線照射】 放射線治療の適応疾患にはどのようなものがありますか？
    Sasaki Ryohei
    Joint work, 日本看護協会出版社, May 2008, Japanese
    Textbook

  • 放射線治療を受ける癌患者の看護ケア / 【放射線照射】 放射線治療の照射法にはどのようなものがありますか？
    Sasaki Ryohei
    Joint work, 日本看護協会出版社, May 2008, Japanese
    Textbook

  • 放射線治療を受ける癌患者の看護ケア / 【放射線照射】 最新の放射線治療にはどのようなものがありますか？
    Nishimura Hideki, Sasaki Ryohei
    Joint work, 日本看護協会出版会, May 2008, Japanese
    Textbook

■ Lectures, oral presentations, etc.
  • 放射線治療のための金ナノ粒子内包アルブミンインプリントナノゲルの創製
    KITAYAMA YUKIYA, 山田託也, 木口 健太朗, 吉田 碧衣, AKASAKA HIROAKI, NISHIMURA YUYA, 五十嵐 一紀, 松本 有, SASAKI RYOHEI, TAKEUCHI TOSHIFUMI
    日本化学会 第99春季年会 (2019), Mar. 2019, English, 日本化学会, 神戸市, Domestic conference
    Oral presentation

  • Radiation therapy for pancreatic cancer using moluculaly imprintednanogels imcopolating gold nanoparticles
    YOSHIDA Aoi, KIGUCHI Kentaro, KITAYAMA Yukiya, AKASAKA Hiroaki, SASAKI Ryohei, TAKEUCHI Toshifumi
    日本化学会 第99春季年会 (2019), Mar. 2019, English, 日本化学会, 神戸市, Domestic conference
    Poster presentation

  • Gold nanoparticle incorporated polymer nanogels for radiation therapy
    YOSHIDA Aoi, YAMADA Takuya, KIGUCHI Kentaro, AKASAKA Hiroaki, SASAKI Ryohei, KITAYAMA Yukiya, TAKEUCHI Toshifumi
    第66回応用物理学会春季学術講演会, Mar. 2019, English, 応用物理学会, 東京都目黒区, Domestic conference
    Poster presentation

  • 稀な松果体乳頭状腫瘍に対して放射線治療を施行した症例
    立花 美保, ISHIHARA TAKEAKI, 佐々木 香織, 妹尾 悟史, 窪田 光, 井上 由子, 川口 弘毅, 西川 遼, MIYAWAKI DAISUKE, YOSHIDA KENJI, SASAKI RYOHEI, 田中 一寛, 篠山 隆司
    第321回公益社団日本医学放射線学会関西地方会(第391回レントゲンアーベント), Feb. 2019, Japanese, 公益社団日本医学放射線学会関西地方会, 大阪, Domestic conference
    Oral presentation

  • IMRTについて ～有望な放射線治療とは～
    SASAKI RYOHEI
    第37回日本口腔腫瘍学会, Jan. 2019, Japanese, 日本口腔腫瘍学会, 長崎, Domestic conference
    [Invited]
    Nominated symposium

  • 放射線治療のための金ナノ粒子内包分子インプリントポリマーナノゲルの開発
    北山 雄己哉, 山田 託也, 木口 健太朗, 吉田 碧衣, AKASAKA HIROAKI, 西村 勇哉, 五十嵐 一紀, 松本 有, SASAKI RYOHEI, 竹内 俊文
    第40回日本バイオマテリアル学会, Nov. 2018, Japanese, 日本バイオマテリアル学会, 京都, Domestic conference
    Oral presentation

  • 放射線治療のための金ナノ粒子内包分子インプリントポリマーナノゲルの開発
    北山 雄己哉, 山田託也, 木口 健太朗, 吉田 碧衣, AKASAKA HIROAKI, NISHIMURA YUYA, 五十嵐 一紀, 松本 有, SASAKI RYOHEI, TAKEUCHI TOSHIFUMI
    第40回日本バイオマテリアル学会大会, Nov. 2018, Japanese, 日本バイオマテリアル学会, 神戸市, Domestic conference
    Oral presentation

  • 放射線治療:QOLを考慮した局所治療 小児がんに対する吸収性スペーサーの開発
    SASAKI RYOHEI, 岩田 宏満, 亀井 美智, 出水 祐介, 文野 誠久, 中尾 朋平, 淡河 恵津世, OH TENEN, 妹尾 悟史, 犬伏 祥子
    第60回日本小児血液がん学会, Nov. 2018, Japanese, 日本小児血液がん学会, 京都, Domestic conference
    [Invited]
    Nominated symposium

  • 非小細胞肺癌の転移性脳腫瘍に対する定位照射に関する検討
    川口 弘毅, 馬屋原 博, ISHIHARA TAKEAKI, SASAKI RYOHEI
    第59回日本肺癌学会, Nov. 2018, Japanese, 日本肺癌学会, 京都, Domestic conference
    Oral presentation

  • In situステルス性獲得にもとづく長期血中滞留性金ナノ粒子内包分子インプリントナノゲルの創製
    北山 雄己哉, 山田 託也, AKASAKA HIROAKI, 西村 勇哉, 五十嵐 一紀, 松本 有, SASAKI RYOHEI, 竹内 俊文
    第40回日本バイオマテリアル学会, Nov. 2018, Japanese, 日本バイオマテリアル学会, 京都, Domestic conference
    Oral presentation

  • 肺不均質ファントムにおける線量計算アルゴリズム精度の検討
    MUKUMOTO NARITOSHI, YADA RYUICHI, 奥村圭祐, 江口力斗, AKASAKA HIROAKI, SHIMIZU YASUYUKI, 大須賀彩希, 西谷隆治, SASAKI RYOHEI
    日本放射線腫瘍学会第31回学術大会, Oct. 2018, Japanese, 日本放射線腫瘍学会, 京都, Domestic conference
    Oral presentation

  • 頭頸部扁平上皮癌術後の再発高リスク症例に対する放射線療法の治療成績の検討
    妹尾悟史, YOSHIDA KENJI, MIYAWAKI DAISUKE, ISHIHARA TAKEAKI, 今村善宣, 清田尚臣, 四宮弘隆, 大月直樹, 丹生健一, SASAKI RYOHEI
    日本放射線腫瘍学会第31回学術大会, Oct. 2018, Japanese, 日本放射線腫瘍学会, 京都, Domestic conference
    Oral presentation

  • 当院における悪性脳神経膠腫に対するIMRTの治療成績
    ISHIHARA TAKEAKI, 妹尾悟史, AKASAKA HIROAKI, MUKUMOTO NARITOSHI, 井上由子, 西川遼, MIYAWAKI DAISUKE, YOSHIDA KENJI, SASAKI RYOHEI, 篠山隆司, TANAKA KAZUHIRO
    日本放射線腫瘍学会第31回学術大会, Oct. 2018, Japanese, 日本放射線腫瘍学会, 京都, Domestic conference
    Oral presentation

  • 転移性脳腫瘍に対するサイバーナイフの治療成績及び放射線脳壊死についての検討
    川口弘毅, 馬屋原博, NISHIMURA HIDEKI, 原田文, 橋本直樹, 北谷圭治, 岩下和真, 上原和之, ISHIHARA TAKEAKI, SASAKI RYOHEI
    日本放射線腫瘍学会第31回学術大会, Oct. 2018, Japanese, 日本放射線腫瘍学会, 京都, Domestic conference
    Oral presentation

  • 前立腺癌に対するCTベース画像誘導IMRTにおける金マーカーの有無による治療成績の比較
    馬屋原 博, NISHIMURA HIDEKI, 原田 文, 橋本 直樹, 川口 弘毅, 北谷 圭治, 岩下 和真, 上原 和之, 中山 雅央, 妹尾 悟史, ISHIHARA TAKEAKI, SASAKI RYOHEI
    日本放射線腫瘍学会第31回学術大会, Oct. 2018, Japanese, 日本放射線腫瘍学会, 京都, Domestic conference
    Poster presentation

  • 脊椎転移に対するIMRTの治療成績とFDG-PETによる局所評価
    岩下 和真, NISHIMURA HIDEKI, 馬屋原 博, 原田 文, 橋本 直樹, 川口 弘毅, 北谷 圭治, 上原 和之, ISHIHARA TAKEAKI, 藤井正彦, SASAKI RYOHEI
    日本放射線腫瘍学会第31回学術大会, Oct. 2018, Japanese, 日本放射線腫瘍学会, 京都, Domestic conference
    Poster presentation

  • 食道癌に対する根治的治療としてIMRTを含む放射線治療を用いた症例に関する検討
    北谷 圭治, 馬屋原 博, NISHIMURA HIDEKI, 原田 文, 橋本 直樹, 岩下 和真, ISHIHARA TAKEAKI, 川口 弘毅, 妹尾 悟史, 上原 和之, 藤井 正彦, SASAKI RYOHEI
    日本放射線腫瘍学会第31回学術大会, Oct. 2018, Japanese, 日本放射線腫瘍学会, 京都, Domestic conference
    Poster presentation

  • 消化管近接型肝細胞癌に対する定位放射線治療の治療成績
    橋本 直樹, 馬屋原 博, NISHIMURA HIDEKI, 原田 文, 川口 弘毅, 北谷 圭治, 岩下 和真, 上原 和之, 妹尾 悟史, ISHIHARA TAKEAKI, SASAKI RYOHEI
    日本放射線腫瘍学会第31回学術大会, Oct. 2018, Japanese, 日本放射線腫瘍学会, 京都, Domestic conference
    Oral presentation

  • 甲状腺がんに対するレンバチニブ治療中の観血的処置の安全性に関する遡及的検討
    金原 史朗, KIYOTA NAOMI, 今村 善宣, OTSUKI NAOKI, NIBU KENICHI, MINAMIKAWA TSUTOMU, 原 仁美, 角谷 賢一朗, SASAKI RYOHEI, MINAMI HIRONOBU
    日本甲状腺外科学会, Oct. 2018, Japanese, 横浜, Domestic conference
    Oral presentation

  • 甲状腺がんに対するレンバチニブ治療中の観血的処置の安全性に関する遡及的検討
    金原 史朗, 清田 尚臣, 今村 善宣, 大月 直樹, 丹生 健一, 南川 勉, HARA HITOMI, KAKUTANI KENICHIRO, SASAKI RYOHEI, MINAMI HIRONOBU
    第51回日本甲状腺外科学会学術集会, Oct. 2018, Japanese, 日本甲状腺外科学会, 横浜, Domestic conference
    Oral presentation

  • 巨大腫瘤を呈した進行外陰癌3例に対する放射線治療の経験
    井上 由子, YOSHIDA KENJI, MIYAWAKI DAISUKE, ISHIHARA TAKEAKI, 西川 遼, 川口弘毅, 窪田光, 妹尾 悟史, 佐々木香織, 蝦名康彦, SASAKI RYOHEI
    日本放射線腫瘍学会第31回学術大会, Oct. 2018, Japanese, 日本放射線腫瘍学会, 京都, Domestic conference
    Oral presentation

  • 還元型コエンザイムQ10の摂取形状による放射線防護効果の変化
    SHIMIZU YASUYUKI, MUKUMOTO NARITOSHI, MIYAWAKI DAISUKE, 犬伏祥子, AKASAKA HIROAKI, YADA RYUICHI, 大須賀彩希, SASAKI RYOHEI
    日本放射線腫瘍学会第31回学術大会, Oct. 2018, Japanese, 日本放射線腫瘍学会, 京都, Domestic conference
    Poster presentation

  • Treatment outcomes of radiotherapy or chemoradiotherapy for postoperative locoregional recurrence of non-small cell lung cancer.
    Satoshi Seno, Kenji Yoshida, Daisuke Miyawaki, Takeaki Ishihara, Ryo Nishikawa, Yuko Inoue, Hideki Nishimura, Yoshiaki Okamoto, Yoshihiro Nishimura, Ryohei Sasaki
    ASTRO's 60th Annual Meeting, Oct. 2018, English, ASTRO, San Antonio, International conference
    Poster presentation

  • 放射線治療のための金ナノ粒子内包ステルス性分子インプリントナノゲル
    KITAYAMA YUKIYA, 山田 託也, 木口 健太朗, AKASAKA HIROAKI, 松本 有, SASAKI RYOHEI, TAKEUCHI TOSHIFUMI
    第12回バイオ関連化学シンポジウム, Sep. 2018, Japanese, 日本化学会, 吹田市, Domestic conference
    Poster presentation

  • 放射線治療に用いる金ナノ粒子内包アルブミンインプリントナノゲルの創製
    KITAYAMA YUKIYA, 山田 託也, 木口 健太朗, 吉田 碧衣, AKASAKA HIROAKI, NISHIMURA YUYA, 五十嵐 一紀, 松本 有, SASAKI RYOHEI, TAKEUCHI TOSHIFUMI
    第67回高分子討論会, Sep. 2018, Japanese, 高分子学会, 札幌市, Domestic conference
    Oral presentation

  • 頭頸部癌に対する根治放射線治療後の放射線性顎骨壊死に関する臨床的検討
    窪田光, MIYAWAKI DAISUKE, 岸本恵美, 明石昌也, 中岡藍, 戴云涛, MUKUMOTO NARITOSHI, ISHIHARA TAKEAKI, YOSHIDA KENJI, SASAKI RYOHEI
    第43回神戸放射線腫瘍懇話会, Sep. 2018, Japanese, 神戸放射線腫瘍懇話会, 神戸, Domestic conference
    Oral presentation

  • 呼吸同期IMRTにおけるInterplay Effectの検討
    MUKUMOTO NARITOSHI, 奥村圭祐, YADA RYUICHI, AKASAKA HIROAKI, SHIMIZU YASUYUKI, 大須賀彩希, 中岡藍, 西谷隆治, SASAKI RYOHEI
    第43回神戸放射線腫瘍懇話会, Sep. 2018, Japanese, 神戸放射線腫瘍懇話会, 神戸, Domestic conference
    Oral presentation

  • 金ナノ粒子内包血清アルブミンインプリントナノゲルの放射線増感効果
    吉田 碧衣, 山田 託也, 木口 健太朗, AKASAKA HIROAKI, SASAKI RYOHEI, KITAYAMA YUKIYA, TAKEUCHI TOSHIFUMI
    第67回高分子討論会, Sep. 2018, Japanese, 高分子学会, 札幌市, Domestic conference
    Poster presentation

  • がん細胞由来エクソソームが識別可能な抗体融合エクソソームインプリントセンシング材料
    森 貴翔, 砂山 博文, KITAYAMA YUKIYA, 犬伏 祥子, SASAKI RYOHEI, TAKEUCHI TOSHIFUMI
    第12回バイオ関連化学シンポジウム, Sep. 2018, Japanese, 日本化学会, 吹田市, Domestic conference
    Oral presentation

  • ガントリー取付式2次元検出器を用いたVMAT検証の可能性・3次元検出器と比較して
    MUKUMOTO NARITOSHI, 奥村圭祐, YADA RYUICHI, AKASAKA HIROAKI, 西谷隆治, SASAKI RYOHEI
    第116回日本医学物理学会学術大会, Sep. 2018, Japanese, 日本医学物理学会, 岩手, Domestic conference
    Oral presentation

  • Effect of exosome of radiation-induced cervical adenocarcinoma
    Sachiko Inubushi, Yoshiko Fujita, Ryohei Sasaki
    第10回日本RNAi研究会 第5回日本細胞外小胞学会, Aug. 2018, English, 日本RNAi研究会日本細胞外小胞学会, 広島, Domestic conference
    Poster presentation

  • 腹部悪性腫瘍に対する粒子線治療適応拡大を可能とする新規素材吸収性スペーサーの開発と臨床応用
    小松 昇平, 木戸 正浩, 田中 基文, 外山 博近, 上野 公彦, 味木 徹夫, 出水 祐介, 沖本 智昭, SASAKI RYOHEI, 福本 巧
    第73回日本消化器外科学会総会, Jul. 2018, Japanese, 日本消化器外科学会総会, 鹿児島, Domestic conference
    Oral presentation

  • 木村氏病３例に対する放射線治療の経験
    妹尾 悟史, MIYAWAKI DAISUKE, YOSHIDA KENJI, ISHIHARA TAKEAKI, 西川 遼, 井上 由子, 窪田 光, 佐々木 香織, SASAKI RYOHEI
    第319回公益社団日本医学放射線学会関西地方会(第391回レントゲンアーベント), Jun. 2018, Japanese, 公益社団日本医学放射線学会関西地方会, 大阪, Domestic conference
    Oral presentation

  • 甲状腺癌気道浸潤例に対する放射線外照射の有効性の検討
    鈴木 千晶, KIYOTA NAOMI, OTSUKI NAOKI, 宮脇 大輔, 今村 善宣, NIBU KENICHI, SASAKI RYOHEI
    頭頸部癌学会, Jun. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 甲状腺癌気管浸潤例に対する放射線外照射の有効性の検討
    鈴木 千晶, 清田 尚臣, 大月 直樹, MIYAWAKI DAISUKE, 今村 善宣, 丹生 健一, SASAKI RYOHEI
    第42回日本頭頸部癌学会, Jun. 2018, Japanese, 日本頭頸部癌学会, 東京, Domestic conference
    Oral presentation

  • 甲状腺がんに対するレンバチニブ治療中の観血的処置の安全性に関する遡及的検討
    金原 史朗, 清田 尚臣, 今村 善宣, 大月 直樹, 丹生 健一, 南川 勉, 原 仁美, 角谷 賢一朗, SASAKI RYOHEI, 南 博信
    日本内分泌外科学会, Jun. 2018, Japanese, 日本内分泌外科学会, 札幌, Domestic conference
    Oral presentation

  • 過酸化チタンナノ粒子の併用による放射線増感治療法の開発
    西村 勇哉, 森田 健太, 荻野 千秋, 犬伏 祥子, SASAKI RYOHEI, 近藤 昭彦
    第34回日本DDS学会, Jun. 2018, Japanese, 日本DDS学会, 長崎, Domestic conference
    Oral presentation

  • 過酸化チタンナノ粒子の併用による放射線増感治療法の開発
    NISHIMURA YUYA, 森田 健太, OGINO CHIAKI, 犬伏 祥子, SASAKI RYOHEI, KONDO AKIHIKO
    第34回日本DDS学会学術集会, Jun. 2018, Japanese, 長崎ブリックホール, Domestic conference
    Poster presentation

  • MOLECULARLY IMPRINTED NANOGELS ACQUIRING STEALTH PROPERTY VIA REGULATING PROTEIN CORONA USING INTRINSIC SERUM ALBUMIN IN SITU
    KITAYAMA Yukiya, YAMADA Takuya, AKASAKA Hiroaki, NISHIMURA Yuya, IGARASHI Kazunori, MATSUMOTO Yu, SASAKI Ryohei, TAKEUCHI Toshifumi
    The 10th International Conference on Molecular Imprinting, Jun. 2018, English, The Society for Molecular Imprinting, Jerusalem,Israel, International conference
    Oral presentation

  • In situステルス性獲得にもとづく長期血中滞留性金ナノ粒子内包分子インプリントナノゲル の創製
    KITAYAMA YUKIYA, 山田 託也, AKASAKA HIROAKI, NISHIMURA YUYA, 五十嵐 一紀, 松本 有, SASAKI RYOHEI, TAKEUCHI TOSHIFUMI
    第34回日本DDS学会学術集会, Jun. 2018, Japanese, 長崎市, Domestic conference
    Poster presentation

  • Application of dual-energy CT to suppression of metal artifacts caused by spinal implant in radiotherapy
    Tianyuan Wang, Takeaki Ishihara, Atsushi Kono, Naoki Yoshida, Noriyuki Negi, Kenichiro Kakutani, Hiroaki Akasaka, Ryuichi Yada, Naritoshi Mukumoto, Daisuke Miyawaki, Kenji Yoshida, Ryohei Sasaki
    World Congress on Medical Physics and Biomedical Engineering 2018, Jun. 2018, English, Prague, International conference
    Oral presentation

  • 小児がんの粒子線治療における吸収性スペーサーの開発に向けて
    亀井 美智, 岩田 宏満, 増本 幸二, 中尾 朋平, 新開 統子, 福島 敬, 櫻井 英幸, 高木 大輔, 近藤 知史, 文野 誠久, 出水 祐介, 石田 裕二, 田尻 達郎, 淡河 恵津世, 副島 俊典, SASAKI RYOHEI
    第55回日本小児外科学会, May 2018, Japanese, 日本小児外科学会, 新潟市, Domestic conference
    Public symposium

  • DDSのための金ナノ粒子含有血清アルブミンインプリントナノゲルの創製
    KITAYAMA YUKIYA, 山田 託也, AKASAKA HIROAKI, 松本 有, SASAKI RYOHEI, TAKEUCHI TOSHIFUMI
    第67回高分子学会年次大会, May 2018, Japanese, 高分子学会, 名古屋市, Domestic conference
    Oral presentation

  • Bystander effect of exosomes derived from cervical adenocarcinoma cells in response to irradiation
    Sachiko Inubushi, Yoshiko Fujita, Ryohei Sasaki
    International Society for Extracellular Vesicles 2018, May 2018, English, International Society for Extracellular Vesicles, Baracelona, International conference
    Poster presentation

  • 粒子線治療適応拡大を可能とするスペーサー手術の現状と展望
    小松 昇平, 木戸 正浩, 田中 基文, 外山 博近, 上野 公彦, 味木 徹夫, 出水 祐介, 沖本 智昭, SASAKI RYOHEI, 福本 巧
    第118回日本外科学会, Apr. 2018, Japanese, 日本外科学会, 京都, Domestic conference
    Oral presentation

  • 局所進行直腸癌に対する術前化学放射線療法の治療成績
    井上 由子, YOSHIDA KENJI, MIYAWAKI DAISUKE, ISHIHARA TAKEAKI, 西川 遼, 妹尾 悟史, 掛地 吉弘, SASAKI RYOHEI
    第77回日本医学放射線学会総会, Apr. 2018, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Oral presentation

  • Dosimetric accuracy of dose calculation algorithms for lung heterogeneity phantom
    Naritoshi Mukumoto, Ryuichi Yada, Keisuke Okumura, Hiroaki Akasaka, Yasuyuki Shimizu, Tianyuan Wang, Saki Osuga, Takaharu Nishitani, Yuichi Aoyama, Ryohei Sasaki
    第115回日本医学物理学会学術大会, Apr. 2018, Japanese, 日本医学物理学会, 横浜, Domestic conference
    Oral presentation

  • 金ナノ粒子内包分子インプリントナノゲルの放射線増感効果
    YOSHIDA Aoi, YAMADA Takuya, KIGUCHI Kentaro, AKASAKA Kosuke, SASAKI Ryohei, KITAYAMA Yukiya, TAKEUCHI Toshifumi
    応用物理学会第65回応用物理学会春季学術講演会, Mar. 2018, Japanese, 応用物理学会, 東京都新宿区, Domestic conference
    Oral presentation

  • 非小細胞肺癌術後再発に対する放射線治療の検討
    妹尾 悟史, Yoshida Kenji, 西川 遼, 井上 由子, Ishihara Takeaki, Miyawaki Daisuke, 西村 英輝, Nishimura Yoshihiro, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Poster presentation

  • 当院における低・中リスク前立腺癌に対するヨード永久刺入療法の治療成績
    Yoshida Kenji, Furukawa Jyunya, Miyawaki Daisuke, Ishihara Takeaki, Uezono Haruka, Akasaka Hiroaki, 西谷 隆治, Fujisawa Masato, Sasaki Ryohei
    日本放射線腫瘍学会小線源部会第19回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 奈良, Domestic conference
    Oral presentation

  • 当院における低・中リスク前立腺癌に対するヨード永久刺入療法の治療成績
    Yoshida Kenji, Furukawa Jyunya, Miyawaki Daisuke, Ishihara Takeaki, Uezono Haruka, Akasaka Hiroaki, 西谷 隆治, Fujisawa Masato, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Poster presentation

  • 当院における胃非ホジキンリンパ腫に対する放射線治療の経験
    梶原 彰文, Yoshida Kenji, 妹尾 悟史, 西川 遼, Ishihara Takeaki, Uezono Haruka, Miyawaki Daisuke, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Poster presentation

  • 切除可能局所進行頭頸部癌に対するTPE導入化学療法とCmab併用放射線治療の第2相試験
    太田 陽介, 小林 雅夫, Sasaki Ryohei, 利安 隆史, 吉村 通央, 萬 篤憲, 村上 祐司, 片岡 正明, 山中 竹春, 全田 貞幹, 田原 信
    日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Oral presentation

  • 神経線維腫症1型（NF1）に生じた悪性末梢神経鞘腫に対する放射線治療経験
    松田 耕平, Miyawaki Daisuke, Yoshida Kenji, Ishihara Takeaki, 西川 遼, 井上 由子, 妹尾 悟史, Sasaki Ryohei
    第317回公益社団法人日本医学放射線学会関西地方会（第389回レントゲンアーベント）, Nov. 2017, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • 小線源治療開始時の残存腫瘍体積と腫瘍縮小率に基づく子宮頸癌患者のリスク分類
    西川 遼, Yoshida Kenji, Ebina Yasuhiko, 表田 真弓, Miyawaki Daisuke, Ishihara Takeaki, Takahashi Satoru, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Oral presentation

  • 子宮頸部腺癌に対する根治的放射線治療成績の検討
    佐々木 香織, Yoshida Kenji, 川口 弘毅, 西川 遼, Ishihara Takeaki, Miyawaki Daisuke, 江島 泰生, Sasaki Ryohei, 蛯名 康彦
    日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Poster presentation

  • 金ナノ粒子との比較による過酸化チタンナノ粒子の放射線増感効果の有用性の検討
    中山 雅央, Akasaka Hiroaki, 椋本 成俊, 荻野 千秋, 西村 勇哉, 森田 健太, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Oral presentation

  • Experience of Neoadjuvant Chemoradiotherapy for locally advanced rectal cancer
    井上 由子, Yoshida Kenji, Miyawaki Daisuke, Uezono Haruka, Ishihara Takeaki, 西川 遼, 妹尾 悟史, Kakeji Yoshihiro, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Oral presentation

  • 巨大腫瘤を呈した進行外陰癌3例に対する放射線治療の経験
    井上 由子, Yoshida Kenji, Miyawaki Daisuke, Uezono Haruka, Ishihara Takeaki, 西川 遼, 妹尾 悟史, Ebina Yasuhiko, Sasaki Ryohei
    第317回公益社団法人日本医学放射線学会関西地方会（第389回レントゲンアーベント）, Nov. 2017, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • 胃癌切除術後の孤発性腹部リンパ節再発に対する強度変調放射線治療の初期経験
    馬屋原 博, 西村 英輝, 原田 文, 橋本 直樹, 川口 弘毅, Uezono Haruka, Ishihara Takeaki, 中山 雅央, 上原 和之, Sasaki Ryohei, 藤井 正彦
    日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Oral presentation

  • Study on PET-CT in judgment of therapeutic effect of radiotherapy for lymph node metastasis
    川口 弘毅, 西村 英輝, 馬屋原 博, 原田 文, 橋本 直樹, Miyawaki Daisuke, Uezono Haruka, Ishihara Takeaki, 藤井 正彦, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Poster presentation

  • The process of the determination of Dosimetric leaf gap and Transmission for VMAT using TrueBeamTM STx
    Akasaka Hiroaki, Naritoshi Mukumoto, Ryuichi Yada, Tianyuan Wang, Yasuyuki Shimizu, Saki Osuga, Yuichi Aoyama, Sasaki Ryohei
    8th Japan-Korea Joint Meeting on Medical Physics, Nov. 2017, English, 日本医学物理学会, 大阪, International conference
    Oral presentation

  • Risk Group Analyses in Cervical Cancer Patients Based on Residual Tumor Volume and Tumor Reduction Ratio at the Time of Image Guided Adaptive Brachytherapy
    R. Nishikawa, Yoshida Kohsuke, Ebina Yasuhiko, M. Omoteda, Y. Ejima, Miyawaki Daisuke, Ishihara Takeaki, Takahashi Satoru, Sasaki Ryohei
    ASTRO's 59th Annual Meeting, Nov. 2017, English, American Society for Radiation Oncology, San Diego, International conference
    Poster presentation

  • Novel application of Dual Energy CT for the suppression of metal artifact in Radiotherapy
    王 天縁, Ishihara Takeaki, 吉田 直基, Kakutani Kenichiro, Miyawaki Daisuke, Yoshida Kenji, Akasaka Hiroaki, 椋本 成俊, 矢田 隆一, 青山 裕一, Takahashi Satoru, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Nov. 2017, English, 日本放射線腫瘍学会, 大阪, Domestic conference
    Poster presentation

  • Influence of the applied voltage on the ion recombination correction factor using the two-voltage technique in FFF beams
    Ryuichi Yada, Naoki Hayashi, Naritoshi Mukumoto, Akasaka Hiroaki, Sasaki Ryohei
    AAPM 59th Annual Meeting & Exhibition, Nov. 2017, English, American Association of Physicists in Medicine, Denver, CO, International conference
    Poster presentation

  • DIRソフトウェアを用いたAdaptive radiation therapyの検討
    椋本 成俊, 矢田 隆一, 清水 康之, 奥村 圭祐, 王 天縁, 大須賀 彩希, Akasaka Hiroaki, 青山 裕一, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Oral presentation

  • Assessment of clinical accuracy of the CyberKnife fiducial-free lung tumor tracking system
    Masao Nakayama, Kazuyuki Uehara, Shinji Tsudou, Shuhei Tamura, Hideki Nishimura, Hiroshi Mayahara, Sasaki Ryohei
    AAPM 59th Annual Meeting & Exhibition, Nov. 2017, English, American Association of Physicists in Medicine, Denver, CO, International conference
    Poster presentation

  • Assessment of adaptive radiation therapy with deformable image registration software
    Naritoshi Mukumoto, Ryuichi Yada, Yasuyuki Shimizu, Keisuke Okumura, Tianyuan Wang, Saki Osuga, Akasaka Hiroaki, Toshiaki Minami, Yuichi Aoyama, Sasaki Ryohei
    第113回日本医学物理学会学術大会, Nov. 2017, Japanese, 日本医学物理学会, 横浜, Domestic conference
    Oral presentation

  • Assessment of adaptive radiation therapy with deformable image registration software
    Naritoshi Mukumoto, Ryuichi Yada, Yasuyuki Shimizu, Keisuke Okumura, Tianyuan Wang, Saki Osuga, Akasaka Hiroaki, Yuichi Aoyama, Sasaki Ryohei
    AAPM 59th Annual Meeting & Exhibition, Nov. 2017, English, American Association of Physicists in Medicine, Denver, CO, International conference
    Poster presentation

  • 2点電圧法を用いたFFFビームのイオン再結合補正係数の印加電圧の影響
    矢田 隆一, 椋本 成俊, Akasaka Hiroaki, 青山 裕一, 村木 勇太, 安達 由美子, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Poster presentation

  • 1期非小細胞肺癌に対するサイバーナイフの局所制御を予測する因子解析
    馬屋原 博, 西村 英輝, 原田 文, 橋本 直樹, 川口 弘毅, Uezono Haruka, Ishihara Takeaki, 中山 雅央, 上原 和之, Sasaki Ryohei, 藤井 正彦
    日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Oral presentation

  • 子宮頸癌に対する組織内照射併用腔内照射と腔内照射治療計画の比較
    表田 真弓, Yoshida Kenji, 西川 遼, 京谷 勉輔, Miyawaki Daisuke, Ebina Yasuhiko, Yamada Hideto, Takahashi Satoru, 青山 裕一, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Oct. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Oral presentation

  • メタボロミクスにおける放射線消化管機能不全指標の解明
    大須賀 彩希, Akasaka Hiroaki, 椋本 成俊, 清水 康之, 王 天縁, Miyawaki Daisuke, Yoshida Kenji, Ishihara Takeaki, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Oct. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Oral presentation

  • 脳転移に対して定位照射を施行ごとに繰り返し神経症状を呈した1例
    Ishihara Takeaki, 妹尾 悟史, 西川 遼, 井上 由子, Uezono Haruka, Miyawaki Daisuke, Yoshida Kenji, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Sep. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Poster presentation

  • 還元型コエンザイムQ10による腸管の有害事象軽減の検討
    清水 康之, 椋本 成俊, Akasaka Hiroaki, 矢田 隆一, 王 天縁, 大須賀 彩希, Miyawaki Daisuke, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Sep. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Poster presentation

  • CT、MRIでの検討に基づく過酸化チタンナノ粒子を用いたTheranostic drugの基礎的検討
    Akasaka Hiroaki, 中山 雅央, 椋本 成俊, 荻野 千秋, 西村 勇哉, 森田 健太, 京谷 勉輔, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Sep. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Poster presentation

  • 腹部悪性腫瘍に対する粒子線治療適応拡大を可能とする新規素材吸収性スペーサーの開発と臨床応用
    Kido Masahiro, 浅利 貞毅, Toyama Hirochika, Ajiki Tetsuo, 具 英成, 出水 祐介, 沖本 智昭, Sasaki Ryohei
    第72回日本消化器外科学会総会, Jul. 2017, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Domestic conference
    Public symposium

  • 多施設共同による頭頸部ハンドブックの作成 -放射線治療後の有害事象へのサポート-
    大田 史江, 平山 知佳, 田中 幸江, 濱島 健児, 山中 真美, 池渕 かおり, 橋口 周子, Miyawaki Daisuke, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Jul. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Poster presentation

  • 上咽頭癌に対する強度変調放射線治療を用いた放射線療法の初期経験
    Miyawaki Daisuke, Ishihara Takeaki, Uezono Haruka, Yoshida Kenji, 清田 直臣, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Jul. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Poster presentation

  • 四肢転移性骨腫瘍患者に対する理学療法の現状
    Akisue Toshihiro, Hara Hitomi, Kakutani Kenichiro, 深瀬 直政, Nishida Kotaro, 江島 泰生, Sasaki Ryohei, Kuroda Ryosuke, Sakai Yoshitada
    The 50th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2017, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference
    Oral presentation

  • 肝細胞癌に対するサイバーナイフによる体幹部定位放射線治療
    馬屋原 博, 橋本 直樹, 原田 文, 西村 英輝, 川口 弘毅, Uezono Haruka, Ishihara Takeaki, 西川 遼, 中山 雅央, 上原 和之, Sasaki Ryohei
    第42回神戸放射線腫瘍懇話会, Jul. 2017, Japanese, 神戸放射線腫瘍懇話会, 神戸, Domestic conference
    Oral presentation

  • 胃癌切除術後の孤発性腹部リンパ節再発に対する強度変調放射線治療の初期経験
    馬屋原 博, 原田 文, 西村 英輝, 橋本 直樹, Uezono Haruka, 川口 弘毅, Ishihara Takeaki, 西川 遼, 中山 雅央, 上原 和之, Sasaki Ryohei, 藤井 正彦
    第55回日本癌治療学会学術集会, Jul. 2017, Japanese, 日本癌治療学会, 横浜, Domestic conference
    Poster presentation

  • 当院における 嗅神経芽細胞腫の検討
    Ohtsuki Naoki, Shinomiya Hirotaka, Inokuchi Gou, Kokan Norio, Kiyota Naomi, Sasaki Ryohei, Kohmura Eiji, Nibu Ken-ichi
    第41回日本頭頸部癌学会, Jun. 2017, Japanese, 京都, Domestic conference
    Oral presentation

  • Induction chemotherapy of TPF for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) - A retrospective safety analysis at our institution -
    Yoshiaki Nagatani, Kiyota Naomi, Yoshinori Imamura, Miyawaki Daisuke, Sasaki Ryohei, Shinomiya Hirotaka, Naoki Otsuki, Kenichi Nibu
    第41回日本頭頸部癌学会, Jun. 2017, Japanese, 日本頭頸部癌学会, 京都, Domestic conference
    Oral presentation

  • 有症状脊椎転移の発生リスクに関する前向き研究
    Kakutani Kenichiro, Sakai Yoshitada, 前野 耕一郎, 江島 泰生, 高田 徹, Sasaki Ryohei, Akisue Toshihiro, Nishida Kotaro, Kuroda Ryosuke
    The 90th Annual Meeting of the Japanese Orthopaedic Association, May 2017, Japanese, The Japanese Orthopaedic Association, 仙台, Domestic conference
    Poster presentation

  • 粒子線治療用吸収性スペーサーの開発
    Sasaki Ryohei
    平成28年度神戸医療機器創出イノベーションフォーラムー現場のひらめきを製品へー, Mar. 2017, Japanese, 神戸大学医学部附属病院, 神戸, Domestic conference
    Public discourse

  • 仙骨脊索腫に対する体内空間可変粒子線治療の長期成績
    津川大介, Fukumoto Takumi, 小松 昇平, 相部則博, 出水祐介, Sasaki Ryohei, 沖本智昭
    第21回兵庫粒子線治療研究会, Mar. 2017, Japanese, 兵庫県立粒子線医療センター, 神戸, Domestic conference
    Public discourse

  • 医学における放射線治療の現況
    Sasaki Ryohei
    Japan Vetarinary Cancer Society the 16th Conference, Jan. 2017, Japanese, 日本獣医がん学会, 大阪, Domestic conference
    [Invited]
    Nominated symposium

  • Treatment outcome of definitive radiotherapy for primary malignant tumor of nasal cavity
    Ryo Nishikawa, Yoshida Kenji, Miyawaki Daisuke, Ishihara Takeaki, Yuko Inoue, Yoshiro Matsuo, Nor Shazrina, Ejima Yasuo, Miki Saito, Kenichi Nibu, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Poster presentation

  • 当院における子宮頸部腺癌の根治的放射線治療の治療成績の検討
    藤本健士郎, 松尾圭朗, Yoshida Kenji, 川口弘毅, 西川 遼, Ishihara Takeaki, Miyawaki Daisuke, Ejima Yasuo, Sasaki Ryohei, 蛯名康彦
    第314回公益社団法人日本医学放射線学会関西地方会（第386回レントゲンアーベント）, Nov. 2016, Japanese, 日本放射線学会, 大阪（ﾎﾃﾙｴﾙｾﾗｰﾝ大阪）, Domestic conference
    Oral presentation

  • Particle therapy for inoperable desmoid tumors
    Yoshiro Matsuo, Yusuke Demizu, Dongcun Jin, Nor Shazrina Sulaiman, Fumiko Nagano, Kazuki Terashima, Osamu Fujii, Sunao Tokumaru, Naoki Hashimoto, Yasue Niwa, Nobukazu Fuwa, Sasaki Ryohei, Tomoaki Okimoto
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Oral presentation

  • Change in the ADC value during the period of whole pelvic radiotherapy for cervical cancer
    Ryo Nishikawa, Yoshida Kenji, Miyawaki Daisuke, Mayumi Omoteda, Katsusuke Kyotani, Kaori Sasaki, Utaru Tanaka, Ebina Yasuhiko, Yamada Hideto, Takahashi Satoru, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Poster presentation

  • The process of thedetermination of Dosimetric leaf gap and Transmission for VMAT using TrueBeam STx
    Akasaka Hiroaki, Toshiaki Minami, Ryuichi Yada, Naritoshi Mukumoto, Tianyuan Wang, Shimizu Yasuyuki, Saki Osuga, Yuki Wakahara, Ishihara Takeaki, Yuichi Aoyama, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Oral presentation

  • The experience of stereotactic radiotherapy by Cyberknife for metastatic brain tumors
    Aya Harada, Hideki Nishimura, Ejima Yasuo, Hiroshi Mayahara, Haruka Uezono, Naoki Hashimoto, Ishihara Takeaki, Masaki Nakamura, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Poster presentation

  • Stereotactic body radiotherapy for second primary lung cancer and intra-parenchymal lung metastasis in patients previously treated with surgery
    Ishihara Takeaki, 山田 和成, 原田 文, 雪上 晴弘, 棚橋 雅幸, 丹羽 宏, 松井 隆, 横村 光司, Miyawaki Daisuke, Yoshida Kenji, Ejima Yasuo, Sasaki Ryohei
    The 29h Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Oral presentation

  • Stereotactic body radiation therapy for re-irradiation in patients with locally recurrent lung tumor
    Haruka Uezono, Hideki Nishimura, Ejima Yasuo, Hiroshi Mayahara, Aya Harada, Naoki Hashimoto, Ishihara Takeaki, Masaki Nakamura, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Poster presentation

  • Preliminary results of Cyberknife stereotactic body radiotherapy for metastatic lung tumors
    Hiroshi Mayahara, Hideki Nishimura, Aya Harada, Naoki Hashimoto, Haruka Uezono, Masaki Nakamura, Ejima Yasuo, Ishihara Takeaki, Masao Nakayama, Sasaki Ryohei, Masahiko Fujii
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Oral presentation

  • Physical analysis of the animal irradiation system in the Kobe University
    Yasuyuki Shimizu, Miyawaki Daisuke, Akasaka Hiroaki, Naritoshi Mukumoto, Masao Nakayama, Tianyuan Wang, Saki Osuga, Yuki Wakahara, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Poster presentation

  • Outcomes of Sequential Chemoradiotherapy for Small-Cell Lung Cancer in Patients Unsuitable for CCRT
    Hiroki Kawaguchi, Ejima Yasuo, Ishihara Takeaki, Miyawaki Daisuke, Yoshida Kenji, Tachihara Motoko, Daisuke Tamura, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Poster presentation

  • Outcomes after radiation therapy for recurrent carcinoma of the oral tongue
    Miyawaki Daisuke, Ejima Yasuo, Yoshida Kenji, Ishihara Takeaki, Kiyota Naomi, Minamikawa Tsutomu, Naoki Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Oral presentation

  • Next-stage Bioabsorbable Spacer in Particle Therapy
    Tianyuan Wang, Akasaka Hiroaki, Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, Ishihara Takeaki, Sachiko Inubushi, Naritoshi Mukumoto, Fukumoto Takumi, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Poster presentation

  • Initial results of stereotactic body radiation therapy with CyberKnife for liver matastases
    Masaki Nakamura, Hideki Nishimura, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Naoki Hashimoto, Ryo Nishikawa, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Poster presentation

  • Initial experience of stereotactic body radiotherapy using Cyberknife for hepatocellular carcinoma
    Naoki Hashimoto, Hiroshi Mayahara, Hideki Nishimura, Haruka Uezono, Aya Harada, Masaki Nakamura, Ejima Yasuo, Ishihara Takeaki, Masao Nakayama, Sasaki Ryohei, Masahiko Fujii
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    [Invited]
    Invited oral presentation

  • Head and neck tumor board: multidisciplinary discussion by expert panel
    Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    [Invited]
    Nominated symposium

  • Experience of IGABT using interstitial needles for locally advanced gynecologic malignancies
    Yoshida Kenji, Ryo Nishikawa, Daisuek Miyawaki, Mayumi Omoteda, Katsusuke Kyotani, Akasaka Hiroaki, Kaori Sasaki, Yoshiro Matsuo, Ebina Yasuhiko, Yamada Hideto, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Poster presentation

  • Elucidation of the radiation gastrointestinal dysfunction index using metabolomics
    Saki Osuga, Sachiko Inubushi, Ejima Yasuo, Akasaka Hiroaki, Yasuyuki Shimizu, Tianyuan Wang, Naritoshi Mukumoto, Miyawaki Daisuke, Yoshida Kenji, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Oral presentation

  • Effectiveness of micro-slit beam radiation therapy for multiplelung-metastatic tumor
    Yuki Wakahara, Naritoshi Mukumoto, Masao Nakayama, Akasaka Hiroaki, Ray Corry Uchida, Yoshida Kenji, Ishihara Takeaki, Miyawaki Daisuke, Keiji Umetani, Ejima Yasuo, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Oral presentation

  • Comparison of dosimetric parameters in the MRI based IGABT with and without optimization
    Mayumi Omoteda, Yoshida Kenji, Ryo Nishikawa, Katsusuke Kyotani, Miyawaki Daisuke, Akasaka Hiroaki, Ebina Yasuhiko, Yamada Hideto, Takahashi Satoru, Yuichi Aoyama, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Poster presentation

  • Changes of ADC and T2 values during external beam radiotherapy for cervical cancer
    Katsusuke Kyotani, Takahashi Satoru, Yoshida Kenji, Ryo Nishikawa, Mayumi Omoteda, Miyawaki Daisuke, Hideaki Kawamitsu, Ebina Yasuhiko, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Oral presentation

  • Assessment of the threshold dose for radiation fibrosis in thoracic esophageal cancer patients
    Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, Ishihara Takeaki, Ryo Nishikawa, Hiroki Kawaguchi, Yoshiro Matsuo, Ikeda Atsuki, Toyoda Masanori, Nakamura Tetsu, Sasaki Ryohei
    The 1st Meeting of the Federation of Asisan Organizations for Radiation Oncology (FARO) held in conjunction with the 29th Annual Meeting of the Japanese Society for Radiation Oncology (JASTRO), Nov. 2016, English, Japanese Society for Radiation Oncology, 京都, International conference
    Poster presentation

  • Assessment of dose calculation accuracy with lung heterogeneity phantom
    Naritoshi Mukumoto, Ryuichi Yada, Keisuke Okumura, Takuro Nishio, Akasaka Hiroaki, Yasuyuki Shimizu, Takaharu Nishitani, Yuichi Aoyama, Miyawaki Daisuke, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Poster presentation

  • A case of uterine cervical cancer presenting with dermatomyositis as a paraneoplastic syndrome
    Kaori Sasaki, Yoshida Kenji, Miyawaki Daisuke, Yoshiro Matsuo, Ryo Nishikawa, Ishihara Takeaki, Ejima Yasuo, Akasaka Hiroaki, Yoshiya Miyawaki, Ueda Takehiro, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Poster presentation

  • 肺不均質ファントムにおける線量計算アルゴリズム精度の検討
    椋本成俊, 矢田隆一, Akasaka Hiroaki, 清水康之, 奥村圭祐, 王天縁, 大須賀彩希, 若原悠希, 青山裕一, Sasaki Ryohei
    The 112th Annual Meeting of the Japanese Society of Medical Physics, Sep. 2016, Japanese, Japanese Society of Medical Physics, 沖縄, Domestic conference
    Poster presentation

  • Separation Surgery後にIMRTを行った脊椎腫瘍の2例
    垣内 裕司, Kakutani Kenichiro, Maeno Koichiro, Ejima Yasuo, 高田 徹, 由留部 崇, 寺嶋 良樹, 伊藤 雅明, 武岡 由樹, Sasaki Ryohei, Kuroda Ryosuke, Nishida Kotaro
    第46回｢脊椎外科を学ぶ会」, Sep. 2016, Japanese, 脊椎外科を学ぶ会, 大阪, Domestic conference
    Oral presentation

  • 転移性脊椎腫瘍患者に対する理学療法の現状
    Akisue Toshihiro, Hara Hitomi, Kakutani Kenichiro, Kawamoto Teruya, 深瀬 直政, Maeno Koichiro, Nishida Kotaro, Ejima Yasuo, Sasaki Ryohei, Sakai Yoshitada
    The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference
    Poster presentation

  • First-Line Chemotherapy for Recurrent or Metastatic Head and Neck Cancer with or without Cetuximab: A single institution experience
    今村 善宣, Kiyota Naomi, Toyoda Masanori, 茶屋原 菜穂子, 後藤 秀彰, Mukohara Toru, Nibu Ken-ichi, Sasaki Ryohei, Minami Hironobu
    第14回日本臨床腫瘍学会, Jul. 2016, English, 日本臨床腫瘍学会, 兵庫, Domestic conference
    Poster presentation

  • 鼻腔腫瘍に対する放射線治療の経験
    西川 遼, Yoshida Kenji, Miyawaki Daisuke, Ishihara Takeaki, 井上 由子, 松尾 圭朗, ノル シャズリナ, Ejima Yasuo, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    The 40th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2016, Japanese, Japan Society for Head and Neck Cancer, Saitama, Japan, 埼玉、ソニックシティー, Domestic conference
    Oral presentation

  • 同時併用化学放射線療法を施行した進行期喉頭癌,下咽頭癌症例におけるTalk Score の検討
    高橋 美貴, 松井 美緒, 涌井 絵美, Kiyota Naomi, Sasaki Ryohei, Ohtsuki Naoki, Usami Makoto, Nibu Ken-ichi
    The 40th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2016, Japanese, Japan Society for Head and Neck Cancer, Saitama, Japan, 埼玉、ソニックシティー, Domestic conference
    Oral presentation

  • 当科で放射線治療を施行した下咽頭癌T1・T2症例の検討
    古川 竜也, Ohtsuki Naoki, Shinomiya Hirotaka, 小松 弘和, Morimoto Koichi, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    The 40th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2016, Japanese, Japan Society for Head and Neck Cancer, Saitama, Japan, 埼玉、ソニックシティー, Domestic conference
    Oral presentation

  • Outcomes after radiation therapy for recurrent carcinoma of the oral tongue
    Miyawaki Daisuke, Ejima Yasuo, Yoshida Kenji, Ishihara Takeaki, 西川遼, Kiyota Naomi, Minamikawa Tsutomu, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    The 40th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2016, Japanese, 日本頭頸部癌学会, 大宮, Domestic conference
    Oral presentation

  • 下部直腸癌・肛門管癌に対する術前化学放射線療法施行後リンパ節郭清の治療成績
    植田 康司, Yamashita Kimihiro, Sumi Yasuo, 金光 聖哲, Yamamoto Masashi, Kanaji Shingo, Oshikiri Taro, Nakamura Tetsu, Suzuki Satoshi, Sasaki Ryohei, Kakeji Yoshihiro
    第38回日本癌局所療法研究会, Jun. 2016, Japanese, 日本癌局所療法研究会, 東京, Domestic conference
    Oral presentation

  • Management of The Patients With Bone Metastasis Under Bone Metastasis Cancer Board,
    Sakai Yoshitada, Kakutani Kenichiro, Hitomi Hara H, Ejima Yasuo, Mai Nakayama, Yoshimichi Kobayashi, Kawamoto Teruya, Maeno Koichiro, Sasaki Ryohei, Kizawa Yoshiyuki, Masahiro Kurosaka, Akisue Toshihiro
    International Society of Physical and Rehabilitation Medicine2016,, Jun. 2016, English, International Society of Physical and Rehabilitation Medicine, Kuala Lumpur, Malaysia, International conference
    Poster presentation

  • First-Line treatment with Cetuximab-based Combination Therapy for Recurrent/Metastatic Head and Neck Cancer: A single institution experience
    今村 善宣, Kiyota Naomi, Ohtsuki Naoki, Morimoto Koichi, Shinomiya Hirotaka, Ejima Yasuo, Minamikawa Tsutomu, Sasaki Ryohei, Nibu Ken-ichi
    第40回日本頭頸部癌学会, Jun. 2016, English, 日本頭頸部癌学会, 埼玉, Domestic conference
    Oral presentation

  • First-line Treatment of Recurrent/Metastatic Head and Neck Cancer with or without Cetuximab
    今村 善宣, Kiyota Naomi, Ohtsuki Naoki, Morimoto Koichi, Shinomiya Hirotaka, Ejima Yasuo, Yoshida Kenji, Minamikawa Tsutomu, Sasaki Ryohei, Nibu Ken-ichi
    The 40th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2016, Japanese, Japan Society for Head and Neck Cancer, Saitama, Japan, 埼玉、ソニックシティー, Domestic conference
    Oral presentation

  • 再発転移頭頸部扁平上皮癌1st line化学療法におけるセツキシマブ併用効果。
    今村 善宣, Kiyota Naomi, Ohtsuki Naoki, Toyoda Masanori, 茶屋原 菜穂子, 後藤 秀彰, Mukohara Toru, Nibu Ken-ichi, Sasaki Ryohei, Minami Hironobu
    第113回日本内科学会総会, Apr. 2016, Japanese, 日本内科学会, 東京, Domestic conference
    Poster presentation

  • radiotherapy for cervical lymph node metastases of unknown primary site
    Yuko Inoue, Yoshida Kenji, Ejima Yasuo, Miyawaki Daisuke, Ishihara Takeaki, Hideki Nishimura, Ryo Nishikawa, Yoshiro Matsuo, Kiyota Naomi, Naoki Otsuki, Kenichi Nibu, Sasaki Ryohei
    The 75th Annual Meeting of the Japan Radiological Society, Apr. 2016, English, Japan Radiological Society, 横浜, Domestic conference
    Oral presentation

  • One-year Experience of MRI Based Image Guided Adaptive Brachytherapy for Cervical Cancer
    Ryo Nishikawa, Yoshida Kenji, Miyawaki Daisuke, Yoshiro Matsuo, Akasaka Hiroaki, Mayumi Omoteda, Katsusuke Kyotani, Fumie Ota, Takahashi Satoru, Hitoaki Satoh, Ebina Yasuhiko, Yamada Hideto, Sasaki Ryohei
    The 75th Annual Meeting of the Japan Radiological Society, Apr. 2016, Japanese, Japan Radiological Society, 横浜, Domestic conference
    Poster presentation

  • Definitive Radiotherapy for T3/T4 Hypopharyngeal Squamous Cell Carcinoma
    Yoshiro Matsuo, Yoshida Kenji, Yuko Inoue, Ryo Nishikawa, Nor Shazrina, Ishihara Takeaki, Miyawaki Daisuke, Ejima Yasuo, Hideki Nishimura, Kiyota Naomi, Miki Saito, Naoki Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    The 75th Annual Meeting of the Japan Radiological Society, Apr. 2016, Japanese, Japan Radiological Society, 横浜, Domestic conference
    Oral presentation

  • 幹細胞癌に対するサイバーナイフによる定位放射線治療の初期経験
    橋本直樹, 西村英輝, 馬屋原博, 上薗 玄, 原田 文, 中村匡希, 尾方俊至, 中山雅央, 松尾圭朗, Sasaki Ryohei
    日本医学放射線学会関西地方会, Feb. 2016, Japanese, JRS-Kansai, 大阪, Domestic conference
    Oral presentation

  • JASTRO放射線治療症例全国登録(JROD)の取組
    沼崎穂高, Sasaki Ryohei, 芥田敬三, 岡嶋 馨, 小川和彦, 上紺屋憲彦, 手島昭樹
    日本医学放射線学会関西地方会, Feb. 2016, Japanese, JRS-Kansai, 大阪, Domestic conference
    Oral presentation

  • Discovery of novel Index of radiation gastrointestinal disorders via metabolomics
    S Osuga, S Inubushi, Ejima Yasuo, Akasaka Hiroaki, Miyawaki Daisuke, Sasaki Ryohei
    The 4th International Symposium of Training Plan for Oncology Professionals, Feb. 2016, English, 大阪, International conference
    Oral presentation

  • Assessment of Apparent Diffusion Coefficient during Image Guided Adaptive Brachytherapy for the Prediction of Local Controllability in Cervical Cancer Treatment: A preliminary histogram analysis
    Ryo Nishikawa, Yoshida Kenji, Miyawaki Daisuke, Akasaka Hiroaki, Takahashi Satoru, Mayumi Omoteda, Katsusuke Kyotani, Sasaki Ryohei
    The 4th International Symposium of Training Plan for Oncology Professionals, Feb. 2016, English, 大阪, International conference
    Poster presentation

  • 明日から使える低侵襲がん放射線療法：IMRT、トモテラピー、サイバーナイフ治療の活用法
    Sasaki Ryohei
    平成27年度明石市医師会内科医会学術講演会, Dec. 2015, Japanese, 明石市医師会, 明石, Domestic conference
    [Invited]
    Invited oral presentation

  • Response of multiple lung-metastatic tumor to microplanar beam irradiation
    Naritoshi Mukumoto, Masao Nakayama, Akasaka Hiroaki, Ray Cory Uchida, Keiji Umetani, Nobuteru Nariyama, Ishihara Takeaki, Miyawaki Daisuke, Yoshida Kenji, Ejima Yasuo, Sasaki Ryohei
    The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conference
    Oral presentation

  • Radiotherapy for portal vein tumor thrombosis or inferior vena cava tumor thrombosis: Comparison with stereotactic body radiotherapy and 3-dimensional conformal radiotherapy
    Yoshiro Matsuo, Yoshida Kenji, Hideki Nishimura, Ejima Yasuo, Hiroshi Mayahara, Miyawaki Daisuke, Haruka Uezono, Aya Harada, Ishihara Takeaki, Sasaki Ryohei
    The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conference
    Oral presentation

  • RADIOTHERAPY FOR CERVICAL LYMPH NODE METASTASES OF UNKNOWN PRIMARY SITE
    Inoue Yukako, Yoshida Kohsuke, Ejima Yasuo, Miyawaki Daisuke, Ishihara Takeaki, R.Nishikawa, Y.Matsuo, H.Nishimura, N.Otsuki, Saito Miki, Kiyota Naomi, Nibu Ken-ichi, Sasaki Ryohei
    The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conference
    Oral presentation

  • Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: a Dose-Volume Histogram Analysis
    Miyawaki Daisuke, N. Mukumoto, Ejima Yasuo, Yoshida Kohsuke, Ishihara Takeaki, Kiyota Naomi, Saito Miki, N. Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conference
    Oral presentation

  • Prognostic value of FDG PET imaging in pharyngeal cancer patients treated with radiotherapy alone or chemoradiotherapy
    Ishihara Takeaki, Kazuhiro Kitajima, Yuko Suenaga, Ejima Yasuo, Saito Miki, Naoki Otsuki, Nibu Ken-ichi, Kiyota Naomi, Takahashi Satoru, Sasaki Ryohei
    The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conference
    Oral presentation

  • Pattern of recurrence after high-dose methotrexate followed by radiotherapy for primary central nervous system lymphoma
    Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, Ishihara Takeaki, Ryo Nishikawa, Yoshiro Matsuo, Yuko Inoue, Sasayama Takashi, Sasaki Ryohei
    The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conference
    Poster presentation

  • Outcomes of radiotherapy for oro- or hypopharyngeal cancer with concomitant esophageal cancer
    Ryo Nishikawa, Yoshida Kenji, Miyawaki Daisuke, Ejima Yasuo, Ishihara Takeaki, Yoshiro Matsuo, Nor Shazrina, Yuko Inoue, Hideki Nishimura, Kiyota Naomi, Saito Miki, Naoki Otsuki, Ken-ihci Nibu, Sasaki Ryohei
    The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conference
    Poster presentation

  • Improvement of Abdominal Radiation-induced Anorexia by Rikkunshito
    Y Shimizu, Miyawaki Daisuke, N Mukumoto, R Uchida, Akasaka Hiroaki, Ishihara Takeaki, Yoshida Kohsuke, Ejima Yasuo, Sasaki Ryohei
    The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conference
    Poster presentation

  • Effects of the synchrotron X-ray microbeam spacing on mouse normal brain tissue
    Masao Nakayama, Naritoshi Mukumoto, Akasaka Hiroaki, Miyawaki Daisuke, Hideki Nishimura, Keiji Umetani, Takeshi Kondoh, Sasaki Ryohei
    The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conference
    Oral presentation

  • Early Experience of Image Guided Adaptive Brachytherapy using Magnetic Resonance Imaging
    Yoshida Kenji, Miyawaki Daisuke, Yoshiro Matsuo, Ryo Nishikawa, Akasaka Hiroaki, Mayumi Omoteda, Katsusuke Kyotani, Fumie Ota, Takahashi Satoru, Hitoaki Satoh, Ebina Yasuhiko, Yamada Hideto, Sasaki Ryohei
    The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, English, JASTRO, 群馬, Domestic conference
    Oral presentation

  • A Future Radiosensitizor from the Spinach, MGDG, Induced Apoptosis in the Pancreatic Cancer Cells Combined with Radiation In vitro and In vivo
    Akasaka Hiroaki, Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, Ishihara Takeaki, Naritoshi Mukumoto, Yoshiro Matsuo, Haruka Uezono, Yoshiyuki Mizushina, Sasaki Ryohei
    The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conference
    Oral presentation

  • 放射線治療、粒子線治療に関連するトランスレーショナルリサーチ
    Sasaki Ryohei
    第12回中部放射線治療研究会学術講演会, Oct. 2015, Japanese, 中部放射線治療研究会学術講演会, 名古屋, Domestic conference
    [Invited]
    Invited oral presentation

  • Translational radiotherapeutic approaches toward pancreatic cancer.Bio-absorbable spacer and bio-modulation by foods: efficacy of reduced form coenzyme Q10 and monogalactosyl diacylglycerol(MGDG) from spinach
    Sasaki Ryohei
    The 2nd EU-Japan International Forum on Health Management, Oct. 2015, English, Wageningen, Nederland, International conference
    Oral presentation

  • Spinal Instability Is Associated With Local Failure After Radiation Therapy in Patients With Spinal Metastases
    Ejima Yasuo, Kakutani Kenichiro, Sakai Yoshitada, Yoshida Kenji, Miyawaki Daisuke, Ishihara Takeaki, Hara Hitomi, Akisue Toshihiro, Nishida Kotaro, Sasaki Ryohei
    57th Annual Meeting of the American Society for Radiation Oncology (ASTRO), Oct. 2015, English, American Society for Radiation Oncology, San Antonio, USA, International conference
    Poster presentation

  • Radiotherapy for T3/T4 squamous cell carcinoma of hypopharynx: retrospective comparison between definitive radiotherapy and surgery followed by postoperative radiotherapy
    Yoshiro Matsuo, Yoshida Kenji, Yuko Inoue, Ryo Nishikawa, Nor Shazrina, Ishihara Takeaki, Miyawaki Daisuke, Ejima Yasuo, Hideki Nishimura, Kiyota Naomi, Saito Miki, Naoki Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    57th Annual Meeting of ASTRO, Oct. 2015, English, ASTRO, San Antonio, USA, International conference
    Poster presentation

  • Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: a Dose-Volume Histogram Analysis
    Miyawaki Daisuke, N. Mukumoto, Ejima Yasuo, Yoshida Kohsuke, Ishihara Takeaki, Kiyota Naomi, Saito Miki, N. Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    57th Annual Meeting of ASTRO, Oct. 2015, English, ASTRO, San Antonio, USA, International conference
    Poster presentation

  • Hypofractionated Stereotactic radiotherapy Compared with Stereotactic Radiosurgery for brain metastases from Lung Cancer: Experience at a Single Institution
    Ishihara Takeaki, Kazunari Yamada, Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, Haruka Uezono, Shazrina Sulaiman, Yoshirou Matsuo, Ryo Nishikawa, Sasaki Ryohei
    57th Annual Meeting of ASTRO, Oct. 2015, English, ASTRO, San Antonio, USA, International conference
    Poster presentation

  • Assessment of parametrial response by growth pattern in patients with FIGO stage IIB and IIIB cervical cancer: analysis of a prospective multicentric trial (EMBRACE)
    Yoshida Kenji, Noha Jastaniyah, Alina Sturdza, Jacob Lindegaard, Barbara Segedin, Umesh Mahantshetty, Firuza Patel, Ina Jürgenliemk-Schulz, Christine Haie-Meder, Sasaki Ryohei, Richard Pötte
    57th Annual Meeting of ASTRO, Oct. 2015, English, ASTRO, San Antonio, USA, International conference
    Oral presentation

  • A Novel Radiosensitizor from the Component of Spinach, MGDG, Induced Apoptosis in the Pancreatic Cancer Cells Combined with Radiation
    Akasaka Hiroaki, Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, Ishihara Takeaki, Naritoshi Mukumoto, Yoshiro Matsuo, Haruka Uezono, Yoshiyuki Mizushina, Sasaki Ryohei
    ASTRO 57th Annual Meeting, Oct. 2015, English, ASTRO, San Antonio, USA, International conference
    Poster presentation

  • 80歳以上の子宮頸癌患者に対する放射線治療の経験
    Yoshida Kenji, 西川遼, 深澤麻衣, Ejima Yasuo, Miyawaki Daisuke, 井上由子, 松尾圭朗, Ishihara Takeaki, Ebina Yasuhiko, Sasaki Ryohei
    第311 回日本医学放射線学会関西地方会, Oct. 2015, Japanese, 日本医学放射線学会関西地方会, 大阪, Domestic conference
    Oral presentation

  • 当院におけるMRIを用いた婦人科癌画像誘導小線源治療の運用と初期経験
    Yoshida Kenji, Miyawaki Daisuke, 松尾圭朗, 西川遼, 表田真弓, 京谷勉輔, Akasaka Hiroaki, 大田史江, Sato Hitoaki, Ebina Yasuhiko, Yamada Hideto, Takahashi Satoru, Sasaki Ryohei
    神戸放射線腫瘍懇話会, Sep. 2015, Japanese, 神戸, Domestic conference
    Oral presentation

  • Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: a Dose-Volume Histogram Analysis
    Miyawaki Daisuke, N. Mukumoto, Ejima Yasuo, Yoshida Kohsuke, Ishihara Takeaki, Kiyota Naomi, Saito Miki, N. Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    European Cancer Congress 2015, Sep. 2015, English, European Cancer Congress, Vienna, Austria, Austria, International conference
    Poster presentation

  • 脊椎転移に集学的治療の予後改善効果
    Kakutani Kenichiro, Sakai Yoshitada, Maeno Koichiro, 高田 徹, 由留部 崇, 宮崎 真吾, 寺嶋 良樹, 伊藤 雅明, Ejima Yasuo, Kawamoto Teruya, Hara Hitomi, 坂下 明大, Sasaki Ryohei, Akisue Toshihiro, Kurosaka Masahiro, Nishida Kotaro
    4th Annual Meeting Japan Association of Spine Surgeons with Ambition, Aug. 2015, Japanese, Japan Association of Spine Surgeons with Ambition, 福岡, Domestic conference
    Oral presentation

  • 当院における四肢転移性骨腫瘍に対する外科的治療成績
    Hara Hitomi, Sakai Yoshitada, Kawamoto Teruya, 大西 康央, 蓑田 正也, 森下 雅之, 蒲田 悦子, Kakutani Kenichiro, Ejima Yasuo, 坂下 明大, Sasaki Ryohei, Nishida Kotaro, Kurosaka Masahiro, Akisue Toshihiro
    The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conference
    Oral presentation

  • 脊椎転移に集学的治療の予後改善効果
    Kakutani Kenichiro, Sakai Yoshitada, Maeno Koichiro, 高田 徹, 由留部 崇, 蔵川 拓外, 宮崎 真吾, 寺嶋 良樹, 伊藤 雅明, Ejima Yasuo, Kawamoto Teruya, Hara Hitomi, 坂下 明大, Sasaki Ryohei, Akisue Toshihiro, Kurosaka Masahiro, Nishida Kotaro
    The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conference
    Poster presentation

  • 骨転移キャンサーボード（bone metastasis board:BMB)による転移性骨腫瘍のマネジメント
    Sakai Yoshitada, Kakutani Kenichiro, Hara Hitomi, 江島 泰夫, 坂下 明大, 赤羽 志保, Kawamoto Teruya, Maeno Koichiro, Kizawa Yoshiyuki, Sasaki Ryohei, Nishida Kotaro, Kurosaka Masahiro, Akisue Toshihiro
    The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conference
    Public symposium

  • Prognostic Value of the Inflammation Markers for Platinum Refractory Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
    Yoshinori Imamura, Kiyota Naomi, Naoki Otsuki, Toyoda Masanori, Chayahara Naoko, Meiko Nishimura, Mukohara Toru, Nibu Ken-ichi, Sasaki Ryohei, Minami Hironobu
    第13回日本臨床腫瘍学会学術集会, Jul. 2015, English, 日本臨床腫瘍学会, 札幌, Domestic conference
    Poster presentation

  • RADIOTHERAPY FOR CERVICAL LYMPH NODE METASTASES OF UNKNOWN PRIMARY SITE
    井上由子, Yoshida Kenji, Ejima Yasuo, Miyawaki Daisuke, Ishihara Takeaki, ノルシャズリナ, 西川遼, 松尾圭朗, 西村英輝, Ohtsuki Naoki, Saito Miki, Kiyota Naomi, Nibu Ken-ichi, Sasaki Ryohei
    4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, English, Japan Society for Head and Neck Cancer, 神戸, International conference
    Poster presentation

  • Oncological and Functional outcome of locally advanced (T3/T4) hypopharyngeal cancer
    Komatsu Hirokazu, Hirotaka Shinomiya, Morimoto Koichi, Saito Miki, Naoki Otsuki, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology, Jun. 2015, English, Asian Society of Head and Neck Oncology, 兵庫, International conference
    Poster presentation

  • Volumetric modulated arc therapy (VMAT) for head and neck cancer: A planning study on our institution
    T.Y. Wang, Ishihara Takeaki, Ejima Yasuo, Yoshida Kohsuke, Miyawaki Daisuke, Y.Matsuo, R.Nishikawa, Inoue Yukako, Akasaka Hiroaki, N.Mukumoto, Y.Shimizu, S.Osuga, Sasaki Ryohei
    第56回JROG 関西若手放射線治療勉強会, Jun. 2015, Japanese, JROG, 奈良, Domestic conference
    Oral presentation

  • Treatment outcomes of definitive radiotherapy in patients with T3N0M0 laryngeal cancer
    Ishihara Takeaki, Yoshiro Matsuo, Miyawaki Daisuke, Yoshida Kenji, Ejima Yasuo, Morimoto Koichi, Saito Miki, Naoki Otsuki, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    4th Congress of Asian Society of Head and Neck Oncology 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, Japanese, Japan Society for Head and Neck Cancer, 神戸, Domestic conference
    Poster presentation

  • Treatment outcome of parotid cancers
    四宮 瞳, Ohtsuki Naoki, Yamashita Daisuke, 今村 善宣, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    2015年6月3日～6日の4th Congress of Asian Society of Head and Neck Oncology, Jun. 2015, English, 日本頭頸部癌学会, 神戸, International conference
    Oral presentation

  • The Utility of Dual-Time-Point FDG PET Imaging in Patients with Oral Tongue Squamous Cell Carcinoma.
    Yonezawa N, Minamikawa Tsutomu, Takahashi Yutaka, Komatsu Hirokazu, Kitajima K, Sasaki Ryohei, Nibu Ken-ichi, Komori Takahide
    The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, Jun. 2015, Japanese, The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, 神戸, Domestic conference
    Oral presentation

  • Radiotherapy for posterior pharyngeal wall cancer of oropharynx and/or hypopharynx
    Miyawaki Daisuke, Ejima Yasuo, Yoshida Kenji, Ishihara Takeaki, Kiyota Naomi, Saito Miki, Naoki Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, English, 神戸国際会議場, 神戸, International conference
    Poster presentation

  • Radiotherapy for portal vein tumor thrombosis or inferior vena cava tumor thrombosis
    Yoshiro Matsuo, Yoshida Kenji, Hideki Nishimura, Ejima Yasuo, Hiroshi Mayahara, Miyawaki Daisuke, Haruka Uezono, Aya Harada, Ishihara Takeaki, Sasaki Ryohei
    The 3rd Japan-Taiwan Radiation Oncology Symposium, Jun. 2015, English, The 3rd Japan-Taiwan Radiation Oncology Symposium, 山梨, International conference
    Oral presentation

  • Radiotherapy for Head and Neck Cancers with N3 Lymph Node Metastasis
    Yoshida Kenji, Miyawaki Daisuke, Ejima Yasuo, Yoshiro Matsuo, Ryo Nishikawa, Kiyota Naomi, Saito Miki, Naoki Otsuki, Hideki Nisimura, Kenichi Nibu, Sasaki Ryohei
    4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, Japanese, 神戸国際会議場, 神戸, International conference
    Poster presentation

  • Prognostic value of the Inflammation Scores for Platinum Refractory Head and Neck cancer.
    今村善宣, Kiyota Naomi, Ohtsuki Naoki, Saito Miki, Morimoto Koichi, Komatsu Hirokazu, Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, 上薗玄, Ishihara Takeaki, Minamikawa Tsutomu, Sasaki Ryohei, Nibu Ken-ichi
    第39回日本頭頸部癌学会学術集会, Jun. 2015, English, 日本頭頸部癌学会, 神戸, Domestic conference
    Oral presentation

  • Outcomes of radiotherapy for oro and hypopharyngeal cancer with concomitant esophageal cancer
    Ryo Nishikawa, Yoshida Kenji, Miyawaki Daisuke, Ejima Yasuo, Ishihara Takeaki, Yoshiro Matsuo, Nor Shazrina, Yuko Inoue, Hideki Nishimura, Kiyota Naomi, Saito Miki, Naoki Otsuki, Ken-ihci Nibu, Sasaki Ryohei
    4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, English, Japan Society for Head and Neck Cancer, 神戸, International conference
    Poster presentation

  • Definitive radiotherapy for T3/T4 hypopharyngeal squamous cell carcinoma
    Yoshiro Matsuo, Yoshida Kenji, Yuko Inoue, Ryo Nishikawa, Nor Shazrina, Ishihara Takeaki, Miyawaki Daisuke, Ejima Yasuo, Hideki Nishimura, Kiyota Naomi, Saito Miki, Naoki Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, English, Japan Society for Head and Neck Cancer, 神戸, International conference
    Poster presentation

  • cost-utility of surgical treatment for patients with spinal metastasis
    Shingo Miyazaki, Kakutani Kenichiro, Sakai Yoshitada, Maeno Koichiro, Toru Takada, Takashi Yurube, Takuto Kurakawa, Yoshiki Terashima, Ejima Yasuo, Kawamoto Teruya, Hara Hitomi, Akihiro Sakashita, Sasaki Ryohei, Akisue Toshihiro, Tetsuhiro Iguchi
    42nd Annual Meeting of the International Society for the Study of the Lumber Spine, Jun. 2015, English, The International Society for the Study of the Lumbar Spine, San Francisco, USA, International conference
    Oral presentation

  • A Novel method of Radioprotection for the Gastointestinal System: Efficacy of the reduced form of Coenzyme Q10.
    Saki Osuga, Naritoshi Mukumoto, Nelly Binti Idrus, Ray Uchida, Akasaka Hiroaki, Miyawaki Daisuke, Yoshiro Matsuo, Ejima Yasuo, Mitsuaki Kitano, Hiroshi Kubo, Hideyuki Kishida, Yasuda Takahiro, Sasaki Ryohei
    4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, English, Japan Society for Head and Neck Cancer, 神戸, International conference
    Poster presentation

  • A Future Method: Space Modulated Particle Therapy (SMPT) Using a Novel Bioabsorbable Spacer
    Akasaka Hiroaki, Fukumoto Takumi, Miyawaki Daisuke, Naritoshi Mukumoto, Wang Tien Yuan, Shigeru Yamada, Masao Murakami, Yusuke Demizu, Sasaki Ryohei
    The 3rd Japan-Taiwan Radiation Oncology Symposium, Jun. 2015, English, The 3rd Japan-Taiwan Radiation Oncology Symposium, 山梨, International conference
    Oral presentation

  • 高齢者脊椎転移に対する手術成績
    Kakutani Kenichiro, Sakai Yoshitada, Maeno Koichiro, 高田 徹, 由留部 崇, Sasaki Ryohei, Kizawa Yoshiyuki, Akisue Toshihiro, Nishida Kotaro, Kurosaka Masahiro
    The 88th Annual Meeting of the Japanese Orthopaedic Association, May 2015, Japanese, The Japanese Orthopaedic Association, 神戸, Domestic conference
    Poster presentation

  • Tolerance for Micro-slit beam X-ray radiation to Central Nervous System
    Naritoshi Mukumoto, Akasaka Hiroaki, Masao Nakayama, Miura Yasushi, Miyawaki Daisuke, Keiji Umetani, Nobuteru Nariyama, Kunio Shinohara, Takeshi Kondoh, Sasaki Ryohei
    15th International Congress of Radiation Research, May 2015, English, ICRR, 京都, International conference
    Poster presentation

  • Titanium peroxide nanoparticles, as novel radiosensitizers, enhance antitumor efficacy in pancreatic cancer therapy
    Masao Nakayama, Sasaki Ryohei, Chiaki Ogino, Tsutomu Tanaka, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Kazuyoshi Sato, Chiya Numako, Seiichi Takami, Akihiko Kondo
    15th International Congress of Radiation Research, May 2015, English, International Congress of Radiation Research, 京都, International conference
    Poster presentation

  • Spinal instability is associated with local recurrence after radiotherapy in patients with spinal metastases
    Ejima Yasuo, Kakutani Kenichiro, Sakai Yoshitada, Yoshida Kenji, Miyawaki Daisuke, Ishihara Takeaki, Hara Hitomi, Akisue Toshihiro, Nishida Kotaro, Sasaki Ryohei
    The 15th International Congress of Radiation Research, May 2015, English, 京都, International conference
    Poster presentation

  • Radiotherapy for portal vein tumor thrombosis or inferior vena cava tumor thrombosis of hepatocellular carcinoma
    Yoshiro Matsuo, Yoshida Kenji, Hideki Nishimura, Ejima Yasuo, Hiroshi Mayahara, Miyawaki Daisuke, Haruka Uezono, Aya Harada, Ishihara Takeaki, Sasaki Ryohei
    15th International Congress of Radiation Research, May 2015, English, International Congress of Radiation Research, 京都, International conference
    Poster presentation

  • Radiosensitizor extracted from Spinach, MGDG, Enhanced the Cytotoxic Effect for Pancreatic Cancer Cells when combined with Radiation Treatment
    Akasaka Hiroaki, Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, Ishihara Takeaki, Yoshiyuki Mizushina, Sasaki Ryohei
    15th International Congress of Radiation Research, May 2015, English, ICRR, 京都, International conference
    Poster presentation

  • Radioimmunotherapy with 90Y ibritumomab tiuxetan for low grade malignant lymphoma.
    R Nishikawa, Yoshida Kohsuke, Miyawaki Daisuke, Ejima Yasuo, Ishihara Takeaki, Y Matsuo, NS Sulaiman, Inoue Yukako, H Nishimura, Kiyota Naomi, Saito Miki, N Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    15th International Congress of Radiation Research, May 2015, English, 京都, International conference
    Poster presentation

  • Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck
    Miyawaki Daisuke, Ejima Yasuo, Yoshida Kenji, Ishihara Takeaki, Kiyota Naomi, Saito Miki, Naoki Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    15th International Congress of Radiation Research, May 2015, English, International Congress of Radiation Research, 京都, International conference
    Poster presentation

  • Pattern of recurrence after high-dose methotrexate followed by radiotherapy for primary central nervous system lymphoma
    Ejima Yasuo, Miyawaki Daisuke, Ishihara Takeaki, Yoshida Kenji, Sasayama Takashi, Sasaki Ryohei
    MODERN RADIATION FOR LYMPHOMA, UPDATED ROLE AND NEW RULES, May 2015, English, International Lymphoma Radiation Oncology Group, NewYork, USA, International conference
    Poster presentation

  • Next-stage Bioabsorbable Spacer in Particle Therapy
    T.Y. Wang, Akasaka Hiroaki, Ejima Yasuo, Yoshida Kohsuke, Miyawaki Daisuke, Ishihara Takeaki, N Mukumoto, Fukumoto Takumi, Sasaki Ryohei
    15th International Congress of Radiation Research, May 2015, English, 京都, International conference
    Poster presentation

  • Assessment of parametrial response by growth pattern in patients with FIGO stage IIB and IIIB cervical cancer: analysis of a prospective multicentric trial (EMBRACE)
    Yoshida Kenji, Noha Jastaniyah, Alina Sturdza, Jacob Lindegaard, Barbara Segedin, Umesh Mahantshetty, Firuza Patel, Ina Jürgenliemk-Schulz, Christine Haie-Meder, Sasaki Ryohei, Richard Pötte
    15th International Congress of Radiation Research, May 2015, English, International Congress of Radiation Research, 京都, International conference
    Poster presentation

  • 骨転移専門tumor boardの取り組み
    Kakutani Kenichiro, Sakai Yoshitada, Maeno Koichiro, 高田 徹, 由留部 崇, 蔵川 拓外, 宮崎 真吾, 寺嶋 良樹, 伊藤 雅明, Ejima Yasuo, Hara Hitomi, 坂下 明大, Sasaki Ryohei, Akisue Toshihiro, Kurosaka Masahiro, Nishida Kotaro
    The 44th Annual Meeting of the Japanese Society for Spine Surgery and Related Research, Apr. 2015, Japanese, The Japanese Society for Spine Surgery and Related Research, 福岡, Domestic conference
    Oral presentation

  • 高齢者脊椎転移に対する手術成績
    Kakutani Kenichiro, Sakai Yoshitada, Maeno Koichiro, 高田 徹, 由留部 崇, 蔵川 拓外, 宮崎 真吾, 寺嶋 良樹, 伊藤 雅明, Ejima Yasuo, Hara Hitomi, 坂下 明大, Sasaki Ryohei, Akisue Toshihiro, Kurosaka Masahiro, Nishida Kotaro
    The 44th Annual Meeting of the Japanese Society for Spine Surgery and Related Research, Apr. 2015, Japanese, The Japanese Society for Spine Surgery and Related Research, 福岡, Domestic conference
    Oral presentation

  • Treatment results of three dimensional Conformal Radiotherapy and Stereotactic Body Radiotherapy for Portal Vein Tumor Thrombosis or Inferior Vena Cava Tumor Thrombosis in hepatocellular carcinoma
    松尾 圭朗, Yoshida Kenji, 西村 英輝, Ejima Yasuo, 馬屋原 博, Miyawaki Daisuke, 上薗 玄, 原田 文, Ishihara Takeaki, Sasaki Ryohei
    The 74rd Annual Meeting of the Japan Radiological Society, Apr. 2015, English, The Japan Radiological Society, 横浜, Domestic conference
    Poster presentation

  • Titanium peroxide nanoparticles enhance antitumor efficacy through reactive oxygen species in pancreatic cancer radiation therapy
    M Nakayama, Sasaki Ryohei, Mukohara Toru, C Ogino, K Morita, M Umetsu, S Ohara, K Sato, C Numako, S Takami, A Kondo
    AACR Annual Meeting 2015, Apr. 2015, English, American Association for Cancer Research, Philadelphia, USA, International conference
    Poster presentation

  • Prognostic value of FDG PET imaging in patients with pharyngeal cancer and who received definitive radiotherapwith radiotherapy or without chemotherapy
    Ishihara Takeaki, Kazuhiro Kitajima, Yuko Suenaga, Ejima Yasuo, Saito Miki, Naoki Otsuki, Nibu Ken-ichi, Kiyota Naomi, Takahashi Satoru, Sasaki Ryohei
    The 74th Annual Meeting of the Japan Radiological Society, Apr. 2015, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Poster presentation

  • Prognostic factors for local control and survival after radiotherapy in patients with spinal metastases
    Ejima Yasuo, Kakutani Kenichiro, Sakai Yoshitada, Yoshida Kenji, Miyawaki Daisuke, Ishihara Takeaki, Hara Hitomi, Akisue Toshihiro, Nishida Kotaro, Sasaki Ryohei
    第74回日本医学放射線学会, Apr. 2015, English, 日本医学放射線学会, 横浜, Domestic conference
    Oral presentation

  • EuroQOL-5D（EQ-5D)を用いた転移性脊椎腫瘍に対する手術加療の費用対効用
    宮崎 真吾, Kakutani Kenichiro, Sakai Yoshitada, Maeno Koichiro, 高田 徹, 由留部 崇, 蔵川 拓外, 寺嶋 良樹, 江島 泰夫, Kawamoto Teruya, Hara Hitomi, 坂下 明大, Sasaki Ryohei, Akisue Toshihiro, Kurosaka Masahiro, Nishida Kotaro
    The 44th Annual Meeting of the Japanese Society for Spine Surgery and Related Research, Apr. 2015, Japanese, The Japanese Society for Spine Surgery and Related Research, 福岡, Domestic conference
    Oral presentation

  • Assessment of parametrial response by growth pattern in patients with FIGO stage IIB and IIIB cervical cancer: analysis of a prospective multicentric trial (EMBRACE)
    Yoshida Kenji, Noha Jastaniyah, Alina Sturdza, Jacob Lindegaard, Barbara Segedin, Umesh Mahantshetty, Firuza Patel, Ina Jürgenliemk-Schulz, Christine Haie-Meder, Sasaki Ryohei, Richard Pötte
    The 74rd Annual Meeting of the Japan Radiological Society, Apr. 2015, English, The Japan Radiological Society, 横浜, Domestic conference
    Oral presentation

  • 疫学知識からIMRTまで
    Sasaki Ryohei
    第20回がん放射線治療看護セミナー：看護の視点でみる放射線治療計画ｰ頭頸部編(2)ｰ, Mar. 2015, Japanese, /, メルバルク京都(5階・京極), Domestic conference
    [Invited]
    Invited oral presentation

  • みんなの中にある放射線療法
    Sasaki Ryohei
    第288回 須磨区医師会臨床談話会, Mar. 2015, Japanese, /, 神戸医療センター, Domestic conference
    [Invited]
    Invited oral presentation

  • 鼻腔腫瘍に対する放射線治療の経験
    清家翔平, Yoshida Kenji, Miyawaki Daisuke, Ishihara Takeaki, 井上由子, 松尾圭朗, 西川 遼, ノルシャズリナ, Ejima Yasuo, Sasaki Ryohei, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第309 回日本医学放射線学会関西地方会, Feb. 2015, Japanese, 日本医学放射線学会関西地方会, 大阪, Domestic conference
    Oral presentation

  • MLCの違いによる照射野外線量の検討
    Akasaka Hiroaki, 椋本成俊, 王 天縁, 清水康之, 大須賀彩希, Yoshida Kenji, Sasaki Ryohei, 南 利明, 吉田直碁, 西尾卓郎, 西谷隆治, 青山裕一
    第309 回日本医学放射線学会関西地方会, Feb. 2015, Japanese, 日本医学放射線学会関西地方会, 大阪, Domestic conference
    Oral presentation

  • A novel method of radioprotection for the gastrointestinal system: Efficacy of the reduced form of coenzyme Q10
    Y Matsuo, Nelly, N Mukumoto, S Osuga, Sasaki Ryohei
    The 3rd International Symposium of Training Plan for Oncology Professional, Feb. 2015, English, 7－University Joint Project, 大阪, International conference
    Oral presentation

  • 脊椎転移による脊髄損傷リスクの検討（第2報）
    Ejima Yasuo, Kakutani Kenichiro, Sakai Yoshitada, Yoshida Kenji, Miyawaki Daisuke, Uezono Haruka, Ishihara Takeaki, Hara Hitomi, Akisue Toshihiro, Nishida Kotaro, Sasaki Ryohei
    The 27th Annual Meeting of the Japanese society for Radiation Oncology, Dec. 2014, Japanese, The Japanese society for Radiation Oncology, 横浜, Domestic conference
    Oral presentation

  • 進行食道癌による通過障害対する緩和的放射線治療の成績
    Uezono Haruka, Ejima Yasuo, Miyawaki Daisuke, Ishihara Takeaki, ノルシャズリナ, 西川 遼, 井上由子, Ikeda Atsuki, Okuno Tatsuya, Toyoda Masanori, Kiyota Naomi, Sasaki Ryohei
    日本放射線腫瘍学会第27回学術大会, Dec. 2014, Japanese, 日本放射線腫瘍学会, 横浜、パシフィコ横浜, Domestic conference
    Oral presentation

  • 上顎洞癌に対する超選択的動注化学療法併用放射線療法の治療成績
    Miyawaki Daisuke, Ejima Yasuo, Uezono Haruka, Ishihara Takeaki, ノルシャズリナ, Yamaguchi Masato, 四宮弘隆, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    日本放射線腫瘍学会第27回学術大会, Dec. 2014, Japanese, 日本放射線腫瘍学会, 横浜、パシフィコ横浜, 上顎洞扁平上皮癌に対する超選択的動注化学療法併用放射線療法の成績を遡及的に検討, Domestic conference
    Poster presentation

  • 還元型コエンザイムQ10を用いた放射線治療の効果比に関する基礎的検討
    Sasaki Ryohei, 椋本成俊, ネリー, Akasaka Hiroaki, ノルシャズリナ, 内田 玲, Uezono Haruka, Ejima Yasuo, 保多 隆
    日本放射線腫瘍学会第27回学術大会, Dec. 2014, Japanese, 日本放射線腫瘍学会, 横浜、パシフィコ横浜, Domestic conference
    Oral presentation

  • 治療前FDG-PETによる喉頭癌の再発予測
    Kitajima Kazuhiro, 末永裕子, 神田知紀, Miyawaki Daisuke, Yoshida Kenji, Ejima Yasuo, Sasaki Ryohei, Komatsu Hirokazu, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Minamikawa Tsutomu, Kiyota Naomi, Sugimura Kazuro
    第54回日本核医学会学術総会, Nov. 2014, Japanese, The Japan Nuclear Medicine, 大阪, Domestic conference
    Oral presentation

  • 乳癌経過中に癌性髄膜炎との鑑別に苦慮したクリプトコッカス髄膜炎の一例
    浦瀬靖代, Miyawaki Daisuke, Ejima Yasuo, Yoshida Kenji, Uezono Haruka, Ishihara Takeaki, 西川 遼, ノルシャズリナ, 松尾圭朗, Sasaki Ryohei
    第308 回日本医学放射線学会関西地方会, Oct. 2014, Japanese, 日本医学放射線学会関西地方会, 大阪, 乳癌経過中に癌性髄膜炎との鑑別に苦慮したクリプトコッカス髄膜炎についての一例報告, Domestic conference
    Oral presentation

  • 低リスク前立腺癌に対する永久刺入小線源治療の経験 ～成績と有害事象～
    妹尾悟史, Yoshida Kenji, Miyawaki Daisuke, Uezono Haruka, 松尾圭朗, Ejima Yasuo, Sasaki Ryohei
    第308 回日本医学放射線学会関西地方会, Oct. 2014, Japanese, 日本医学放射線学会関西地方会, 大阪, 低リスク前立腺癌に対する永久刺入小線源治療についての報告, Domestic conference
    Oral presentation

  • Efficacy of PGA Spacer in Particle Therapy: A novel strategy Making Temporal Space between Tumor and Adjacent Organs
    Akasaka Hiroaki, Sasaki Ryohei, Miyawaki Daisuke, N Mukumoto, NS Sulaiman, TY Wang, S Yamada, M Murakami, Y Demizu, Fukumoto Takumi
    MMND & IPCT 2014, Oct. 2014, English, University of Wollo0ngong, Port Douglas, Australia, International conference
    [Invited]
    Invited oral presentation

  • TrueBeamシステムによる呼吸同期強度変調回転放射線治療の検討
    上原和之, 尾方俊至, 中山雅央, 津藤真司, 西村英輝, 馬屋原博, 原田文, Sasaki Ryohei, Ejima Yasuo, Miyawaki Daisuke, 岡山貴宣
    KASTRO2014, Sep. 2014, Japanese, KASTRO, Kobe, Domestic conference
    Oral presentation

  • Retrospective analysis of whole brain radiotherapy for brain metastases
    Uezono Haruka, Ejima Yasuo, Miyawaki Daisuke, Ishihara Takeaki, Y Imamura, H Shinomiya, Komatsu Hirokazu, H Fujio, Morimoto Koichi, Saito Miki, N Otsuki, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, We retrospectively reviewed 9 cases who underwent radiotherapy with Cetuximab concurrently. Primary tumor response and acute toxicity are reported. Although mucositis was the most remarkable adverse events, one patient developed grade 5 drug-induced interstitial lung disease., International conference
    Poster presentation

  • Retrospective analysis of risk factors influencing survival and gait disturbance in patients with spinal metastases
    Ejima Yasuo, Kakutani Kenichiro, Sakai Yoshitada, Yoshida Kenji, Miyawaki Daisuke, Uezono Haruka, Hara Hitomi, Akisue Toshihiro, Nishida Kotaro, Sasaki Ryohei
    The 15th Asian Oceanian Congress of Radiology, Sep. 2014, English, Asian Oceanian Congress of Radiology, 神戸, International conference
    Poster presentation

  • Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck
    Miyawaki Daisuke, Ejima Yasuo, Yoshida Kohsuke, H Nishimura, Kiyota Naomi, N Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    The 15th Asian Oceanian Congress of Radiology, Sep. 2014, English, Asian Oceanian Congress of Radiology, Kobe, The purpose of this study was to compare the risk of HT in squamous cell carcinoma of the head and neck undergoing treatment with CCRT or RT alone at our institution, International conference
    Poster presentation

  • Particle Therapy Using Carbon Ions or Protons for Chondrosarcomas; A Single-institution Retrospective Analysis
    Y Demizu, M Mima, D Jin, N Hashimoto, M Takagi, K Katsui, F Nagano, K Terashima, O Fujii, T Okimoto, Y Toyomasu, Y Niwa, Sasaki Ryohei, M Murakami, Y Hishikawa, M Abe, N Fuwa
    The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, International conference
    Oral presentation

  • Particle Beam Radiation Therapy Using Carbon Ions and Protons for Oligometastatic Lung Tumors
    NS Sulaiman, O Fujii, Y Demizu, K Terashima, Y Niwa, T Daimon, T Akagi, M Murakami, Sasaki Ryohei, N Fuwa
    The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, International conference
    Oral presentation

  • Hypofractionated Stereotactic radiotherapy Compared with Stereotactic Radiosurgery for brain metastases from Lung Cancer: Experience at a Single Institution
    Ishihara Takeaki, Yamada Katsumi, Ejima Yasuo, Yoshida Kohsuke, Miyawaki Daisuke, Uezono Haruka, NS Sulaiman, Y Matsuo, R Nishikawa, Sasaki Ryohei, Sugimura Kazuro
    The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, Domestic conference
    Poster presentation

  • Experience of radiotherapy plus cetuximab for head and neck cancer
    Uezono Haruka, Ejima Yasuo, Miyawaki Daisuke, Ishihara Takeaki, Y Imamura, H Shinomiya, Komatsu Hirokazu, H Fujio, Morimoto Koichi, Saito Miki, N Otsuki, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, International conference
    Poster presentation

  • Dose Estimation Of Normal Brain Tissue Tolerance For Microbeam Radiation Therapy
    M Nakayama, N Mukumoto, Akasaka Hiroaki, Miyawaki Daisuke, H Nishimura, K Umetani, N Nariyama, T Kondoh, K Shinohara, Sasaki Ryohei
    ASTRO’s 56th Annual Meeting, Sep. 2014, English, American Society for Radiation Oncology, San Francisco, USA, International conference
    Poster presentation

  • Assessment of Correlation and Prediction Errors of the CyberKnife Synchrony Respiratory Tracking Ststem for the Treatment of Liver Tumors
    M Nakayama, T Ogata, K Uehara, H Nishimura, H Mayahara, A Harada, Y Matsuo, Ejima Yasuo, Miyawaki Daisuke, Sasaki Ryohei, J Ishida, M Fujii
    The 15th Asian Oceanian Congress of Radiology, Sep. 2014, English, Kobe, International conference
    Poster presentation

  • A Novel Radiosensitizer, Monogalactosyl diacylglycerol, Enhanced the Cytotoxic Effects for the Pancreatic Cancer
    Akasaka Hiroaki, Sasaki Ryohei, I Takayama, M Nakahana, NS Sulaiman, Miyawaki Daisuke, Yoshida Kohsuke, Ejima Yasuo, Uezono Haruka, Y Mizushina
    The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, International conference
    Poster presentation

  • A Novel Method for Space Modulated Radiotherapy (SMRT):Nonwoven fabric polyglycolic acid (PGA) spacer
    Sasaki Ryohei, Akasaka Hiroaki, Miyawaki Daisuke, NS Sulaiman, Y Demizu, S Yamada, M Murakami, Fukumoto Takumi
    The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, International conference
    Poster presentation

  • A Novel Metallic Eye Shield for Electron Treatment in Eyelid Skin Cancer: A Dosimetric Study
    N Mukumoto, K Umetani, N Nariyama, T Kondoh, K Shinohara, Sasaki Ryohei
    The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, International conference
    Poster presentation

  • A Novel Metallic Eye Shield for Electron Treatment in Eyelid Skin Cancer: A Dosimetric Study
    N Mukumoto, T Minami, Miyawaki Daisuke, N Yoshida, Akasaka Hiroaki, Uezono Haruka, Ejima Yasuo, Y Aoyama, Sasaki Ryohei
    The 15th Asian Oceanian Congress of Radiology AOCR_2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, International conference
    Poster presentation

  • 2台のtrueBEAMを立ち上げて
    椋本成俊, 青山裕一, 南利明, Akasaka Hiroaki, 西谷隆治, Sasaki Ryohei
    KASTRO2014, Sep. 2014, Japanese, KASTRO, Kobe, Domestic conference
    Oral presentation

  • 体内空間可変粒子線治療による肝胆膵癌の治療
    Fukumoto Takumi, Kido Masahiro, 岡﨑 太郎, 新関 亮, Matsumoto Ippei, Ajiki Tetsuo, 出水 祐介, 不破 信和, Sasaki Ryohei, Ku Yonson
    第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器病学会, 福島, Domestic conference
    Keynote oral presentation

  • Cyberknife Radiotherapy For Recurrent Head And Neck Cancers
    H Nishimura, H Mayahara, A Harada, Y Matsuo, H Tanimoto, Ejima Yasuo, Miyawaki Daisuke, Uezono Haruka, Sasaki Ryohei, M Fujii
    IFHNOS 2014, Jul. 2014, English, International Federation of Head & Neck Oncologic Societies (IFHNOS), NY, USA, International conference
    Poster presentation

  • Clinicopathological Analysis of Salivary Duct Carcinoma and Salivary Gland Adenocarcinoma, N.O.S
    今村 善宣, Kiyota Naomi, Ohtsuki Naoki, 平井 千穂子, Itoh Tomoo, 船越 洋平, Sasaki Ryohei, Nibu Ken-ichi, Mukohara Toru, Minami Hironobu
    The 12th Annual Meeting of Japanese Society of Medical Oncology, Jul. 2014, English, Japanese Society of Medical Oncology, 福岡, Domestic conference
    Poster presentation

  • 免疫組織化学染色による唾液腺導管癌15例の検討．
    今村 善宣, Kiyota Naomi, Ohtsuki Naoki, Yamashita Daisuke, Sasaki Ryohei, Nibu Ken-ichi
    第38回日本頭頸部癌学会, Jun. 2014, Japanese, 日本頭頸部癌学会, 東京, Domestic conference
    Oral presentation

  • 免疫組織化学染色による唾液腺導管癌15例の検討
    今村善宣, Kiyota Naomi, Ohtsuki Naoki, Yamashita Daisuke, Sasaki Ryohei, Nibu Ken-ichi
    The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, Domestic conference
    Oral presentation

  • Experience of radiotherapy plus cetuximab for head and neck cancer
    Uezono Haruka, Ejima Yasuo, Miyawaki Daisuke, 今村善宣, 四宮弘隆, Komatsu Hirokazu, Fujio Kumi, Morimoto Koichi, Saito Miki, Ohtsuki Naoki, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, Domestic conference
    Poster presentation

  • 当科における中咽頭癌症例の臨床的検討
    四宮弘隆, 四宮 瞳, Komatsu Hirokazu, Morimoto Koichi, Saito Miki, Ohtsuki Naoki, Sasaki Ryohei, Nibu Ken-ichi
    The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, Domestic conference
    Oral presentation

  • 当院におけるゼヴァリンの初期経験
    西川 遼, Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, Uezono Haruka, Ishihara Takeaki, ノルシャズリナ, Sasaki Ryohei, Matsuoka Hiroshi, Yakushijin Kimikazu
    第307回公益社団法人日本医学放射線学会関西地方会(第379回レントゲンアーベント), Jun. 2014, Japanese, 公益社団法人日本医学放射線学会関西地方会, 大阪, Domestic conference
    Oral presentation

  • 転移性骨腫瘍に対する放射線腫瘍医の考え方
    Sasaki Ryohei, Ejima Yasuo
    The 19th Congress of the Japanese Society for Palliative Medicine, Jun. 2014, Japanese, Congress of the Japanese Society for Palliative Medicine, 神戸、神戸国際展示場、神戸ポートピアホテル, Domestic conference
    [Invited]
    Invited oral presentation

  • 中咽頭癌に対する化学放射線療法におけるPEG留置患者の栄養投与量と有害事象
    高橋美貴, 小坂奈々, Usami Makoto, 中川絵美, Saito Miki, Ohtsuki Naoki, Ejima Yasuo, Miyawaki Daisuke, Sasaki Ryohei, Kiyota Naomi, Nibu Ken-ichi
    The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, 中咽頭癌に対する化学放射線療法におけるPEG留置患者の栄養投与量と有害事象を検討, Domestic conference
    Oral presentation

  • 進行期喉頭癌・下咽頭癌に対する治療戦略
    Ohtsuki Naoki, 四宮弘隆, Komatsu Hirokazu, Morimoto Koichi, Saito Miki, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, Domestic conference
    Oral presentation

  • 上顎洞扁平上皮癌に対する放射線治療成績
    Miyawaki Daisuke, Ejima Yasuo, Uezono Haruka, 四宮弘隆, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, 上顎洞扁平上皮癌に対する放射線治療成績を検討, Domestic conference
    Poster presentation

  • T3N0-1声門癌に対する喉頭温存を目的とした根治的化学放射線治療の検討
    Sasaki Ryohei, 松尾圭朗, Ejima Yasuo, Miyawaki Daisuke, Uezono Haruka, 今村善宣, Kiyota Naomi, 四宮弘隆, Komatsu Hirokazu, Morimoto Koichi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, Domestic conference
    Oral presentation

  • Particle Therapy Using Carbon Ions or Protons for Chondrosarcomas:a Single-Institution Retrospective Analysis
    Y Demizu, M Mima, D Jin, N Hasimoto, M Takagi, F Nagano, K Katsui, K Terashima, O Fujii, T Okimoto, Yamashita Tomoya, Y Toyomasu, Y Niwa, Sasaki Ryohei, M Murakami, Y Hishikawa, M Abe, N Fuwa
    The 53th Annual Conference of the Particle Therapy Co-Operative Group, Jun. 2014, English, PTCOG 53 Hosting/Organizing Committee, Shanghai, International conference
    Oral presentation

  • Flattening Filter Freeビームを用いた頭頸部VMATの検討
    尾方俊至, 上原和之, 中山雅央, 岡山貴宣, 西村英輝, 馬屋原 博, 原田 文, 松尾圭朗, Ejima Yasuo, Sasaki Ryohei, 藤井正彦
    第307回公益社団法人日本医学放射線学会関西地方会(第379回レントゲンアーベント), Jun. 2014, Japanese, 公益社団法人日本医学放射線学会関西地方会, 大阪, 【目的】頭頸部がんにおいて、汎用型リニアックのFlattening Filter Free（FFF）ビームを用いたVMAT（Volumetric Modulated Arc Therapy）治療計画を立案し、Flattening Filter（FF）装填およびTomoTherapyと比較検討する。【方法】対象は上咽頭がん4例、中咽頭がん3例で、線量処方はSIB法（69.96/60/54 Gy）にて33分割 D95処方とした。VMATプランのエネルギーは6 MVを使用し、2アークのプランとした。ターゲットおよびリスク臓器のDVH、照射MU、照射時間を比較評価した。【結果】FFFによる治療計画は、FFと比較してほぼ同等の線量分布であったが、照射時間の短縮は認めなかった。TomoTherapyと比較するとFFFによる治療計画では、線量均一性で劣ったがほぼ同, Domestic conference
    Oral presentation

  • 転移性脊椎腫瘍に対する放射線療法の現状
    Sasaki Ryohei
    The 87th Annual Meeting of The Japanese Orthopaedic Association ABSTRACTS II, May 2014, Japanese, The Japanese Orthopaedic Association, 神戸、神戸ポートピアホテル, Domestic conference
    [Invited]
    Invited oral presentation

  • 転移性脊椎腫瘍に対する手術成績 -手術、非手術例の生命予後、全身状態、日常生活動作に関する前向き研究-
    Kakutani Kenichiro, Sakai Yoshitada, Maeno Koichiro, 髙田 徹, Ejima Yasuo, Hara Hitomi, Sakashita Akihiro, 平田 裕亮, 蔵川 拓外, 宮崎 真吾, 寺嶋 良樹, Sasaki Ryohei, Akisue Toshihiro, Kurosaka Masahiro, Nishida Kotaro
    The 87th Annual Meeting of the Japanese Orthopaedic Association, May 2014, Japanese, The Japanese Orthopaedic Association, 神戸, Domestic conference
    [Invited]
    Nominated symposium

  • Definitive radiotherapy for T3 laryngeal cancer
    松尾圭朗, Ejima Yasuo, Miyawaki Daisuke, Uezono Haruka, 松本葉子, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    The 73rd Annual Meeting of the Japan Radiological Society, Apr. 2014, English, The Japan Radiological Society, 横浜、パシフィコ横浜, [Objective] The purpose of this study is to evaluate the results of T3 laryngeal cancer with radiotherapy in our institution.[Materials and Methods] Between 2006 and 2013, 20 patients with T3 laryngeal cancer treated with radiotherapy in our institution. Sixteen patients was diagnosed with N0, 2 patients did with N1, 1 patient did with N2, and 1 patient did with N3 disease. Sev, Domestic conference
    Oral presentation

  • 転移性脊椎腫瘍患者の手術、非手術例における生命予後、歩行状態に関する前向き研究
    Kakutani Kenichiro, Sakai Yoshitada, Maeno Koichiro, 高田 徹, Ejima Yasuo, Hara Hitomi, Sakashita Akihiro, 平田 裕亮, 蔵川 拓外, 宮崎 真吾, 寺嶋 良樹, Sasaki Ryohei, Akisue Toshihiro, Kurosaka Masahiro, Nishida Kotaro
    第43回日本脊椎脊髄病学会学術集会, Apr. 2014, Japanese, 日本脊椎脊髄病学会, 神戸, Domestic conference
    Oral presentation

  • Efficacy of Salvage Radiotherapy in Men with Biochemical Recurrence After Radical Prostatectomy: A Comparison with Endocrine Therapy
    ノルシャズリナ, Yoshida Kenji, Miyawaki Daisuke, Ejima Yasuo, Uezono Haruka, 松尾圭朗, 松本葉子, Furukawa Jyunya, Fujisawa Masato, Sasaki Ryohei
    The 73rd Annual Meeting of Japan Radiological Society, Apr. 2014, English, The Japan Radiological Society, 横浜、パシフィコ横浜, Domestic conference
    [Invited]
    Invited oral presentation

  • Retrospective analysis of risk factors influencing survival and gait disturbance in patients with spinal metastases
    Ejima Yasuo, Kakutani Kenichiro, Sakai Yoshitada, Yoshida Kenji, Miyawaki Daisuke, Uezono Haruka, Hara Hitomi, Akisue Toshihiro, Nishida Kotaro, Sasaki Ryohei
    The 73rd Annual Meeting of the Japan Radiological Sociey, Apr. 2014, Japanese, The Japan Radiological Sociey, 横浜, Domestic conference
    Oral presentation

  • 高悪性度転移性脊椎腫瘍患者の手術例における全身状態、日常生活動作に関する前向き研究
    Kakutani Kenichiro, Sakai Yoshitada, Maeno Koichiro, 高田 徹, Ejima Yasuo, Hara Hitomi, Sakashita Akihiro, 平田 裕亮, 蔵川 拓外, 宮崎 真吾, 寺嶋 良樹, Sasaki Ryohei, Akisue Toshihiro, Kurosaka Masahiro, Nishida Kotaro
    第43回日本脊椎脊髄病学会学術集会, Apr. 2014, Japanese, 日本脊椎脊髄病学会, 神戸, Domestic conference
    Oral presentation

  • Treatment outcomes of radiotherapy for T1/T2 supraglottic carcinoma
    松本葉子, Miyawaki Daisuke, Ejima Yasuo, Uezono Haruka, Yoshida Kenji, Sasaki Ryohei, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    The 73rd Annual Meeting of the Japan Radiological Society, Apr. 2014, Japanese, The Japan Radiological Society, 横浜、パシフィコ横浜, Domestic conference
    Poster presentation

  • Retrospective analysis of whole brain radiotherapy for brain metastases
    Uezono Haruka, Ejima Yasuo, 松尾圭朗, ノルシャズリナ, 松本葉子, Miyawaki Daisuke, Yoshida Kenji, Sasaki Ryohei
    The 73rd Annial Meeting of the Japan Radiological Society, Apr. 2014, Japanese, The Japan Radiological Society, 横浜、パシフィコ横浜, We retrospectively reviewed the neurological symptom upon intracranial recurrence after whole brain radiotherapy. Patients who had metastatic lesions in the eloquent area had a tendency to show more severe neurological symptom. We propose larger radiation dose to the eloquent area leisons may be beneficial to preserve those patient neurological function, Domestic conference
    Poster presentation

  • Retrospective analysis of risk factors influencing survival and gait disturbance in patients with spinal metastases
    Ejima Yasuo, Kakutani Kenichiro, Sakai Yoshitada, Yoshida Kenji, Miyawaki Daisuke, Uezono Haruka, Hara Hitomi, Akisue Toshihiro, Nishida Kotaro, Sasaki Ryohei
    第73回日本医学放射線学会, Apr. 2014, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Oral presentation

  • Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck
    Miyawaki Daisuke, Ejima Yasuo, Uezono Haruka, Yoshida Kenji, 西村英輝, 岡本欣晃, Kiyota Naomi, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    The 73rd Annial Meeting of the Japan Radiological Society, Apr. 2014, Japanese, The Japan Radiological Society, 横浜、パシフィコ横浜, The purpose of this study was to compare the risk of HT in squamous cell carcinoma of the head and neck undergoing treatment with CCRT or RT alone at our institution., Domestic conference
    Poster presentation

  • Intra-abdomical space modulated radiotherapy: Safety and efficacy of absorbable spacer in particle therapy
    Sasaki Ryohei, Akasaka Hiroaki, Miyawaki Daisuke, NS Sulaiman, Y Demizu, S Yamada, M Murakami, Fukumoto Takumi
    European Society for Radiotherapy & Oncology 33, Apr. 2014, English, European Society for Radiotherapy & Oncology, Vienna, International conference
    Poster presentation

  • A Novel Radiosensitizer, Monogalactosyl diacylglycerol, Enhanced the Cytotoxic Effects for the Pancreatic Cancer
    Akasaka Hiroaki, Sasaki Ryohei, I Takayama, M Nakahana, NS Sulaiman, Miyawaki Daisuke, Yoshida Kohsuke, Ejima Yasuo, Uezono Haruka, Y Mizushina
    European Society for Radiotherapy & Oncology 33, Apr. 2014, English, European Society for Radiotherapy & Oncology, Vienna, International conference
    Poster presentation

  • 放射線腫瘍学教室を主宰する立場から
    Sasaki Ryohei
    第125回関西Cancer Therapistの会, Mar. 2014, Japanese, 関西Cancer Therapistの会, 大阪(阪急グランドビル26階), Domestic conference
    Oral presentation

  • 腹部・骨盤部悪性腫瘍に対する体内空間可変粒子線治療の治療成績
    Fukumoto Takumi, Kito Masahiro, Takebe Atsushi, Tanaka Motofumi, Kuramitsu Kaori, Asari Sadaki, Okazaki Taro, Shinzeki Makoto, Matsumoto Ippei, Ajiki Tetsuo, 寺嶋千貴, 出水祐介, 不破信和, Sasaki Ryohei, Ku Yonson
    第18回兵庫粒子線治療研究会, Mar. 2014, Japanese, 兵庫粒子線治療研究会, 兵庫(神戸大学医学部附属病院), Domestic conference
    Oral presentation

  • ホウレン草糖脂質MGDGと抗がん剤ゲムシタビンのヒト膵臓がん細胞増殖抑制活性と抗腫瘍活性の相乗効果
    水品義之, 赤坂浩亮, Yoshida Kenji, 高山いずみ, 吉田弘美, Sasaki Ryohei
    日本農芸化学会, Mar. 2014, Japanese, 日本農芸化学会, 京王プラザホテル, 我々は、食品成分や栄養素から哺乳類のDNA合成酵素（DNAポリメラーゼ, Pol）阻害物質を探索している。これまでに、ホウレン草の糖脂質MGDG（monogalactosyl diacylglycerol）がDNA複製型のPol分子種を選択的に阻害して、がん細胞増殖抑制活性を示すことを見出した。ホウレン草のMGDGをがん対策の補助食品として開発することを目的として、既知の抗がん剤であるゲムシタビン（GEM）との併用効果を調査した。, Domestic conference
    Oral presentation

  • 当院におけるPVTT/IVCTTに対する体幹部定位放射線治療の経験
    松尾圭朗, 西村英輝, 馬屋原博, 原田 文, 尾方俊至, 中山雅央, 上原和之, Ejima Yasuo, Miyawaki Daisuke, Uezono Haruka, Sasaki Ryohei, 藤井 正彦
    The 27th Annual Meeting of Japan 3-D Conformal External Beam Radiotherapy Group, Feb. 2014, Japanese, Japan Radiological Society, 東京, [目的] 当院におけるPVTT/IVCTTに対する体幹部定位放射線治療の初期成績について遡及的に検討する。[対象] 2013年4月から10月にかけて体幹部定位放射線治療を施行したPVTT/IVCTT症例13例を対象とした。PTVV9例、IVCTT4例であった。年齢は中央値78歳(44-88歳)、男性10名、女性2名で、放射線治療前のChild-Pugh scoreは5-6点が8例、7-8点が5例、PTV sizeの中央値は34.5ml(14.7-111.0ml)であった。治療はCyberknifeによる追尾照射が6例、Truebeamによる呼吸同期が5例、Truebeamによる息止め照射が2例で、照射線量の中央値は50Gy (40-55Gy)、一回線量の中央値は3.6Gy(2.5-12.5Gy)であった。[結果] 経過観察期間の中央値は3ヶ月(1-7, Domestic conference
    Poster presentation

  • 眼瞼周囲皮膚癌に対する新規眼球シールド使用時の線量分布の検討
    椋本成俊, Miyawaki Daisuke, 赤坂浩亮, 王天縁, 清水康之, Uezono Haruka, Yoshida Kenji, Ejima Yasuo, Sasaki Ryohei, 吉田直碁, 表田真弓, 西谷隆治, 南利明, 青山裕一
    第305回公益社団法人日本医学放射線学会関西地方会, Feb. 2014, Japanese, 日本医学放射線学会関西地方会, 大阪(ホテルエルセラーン大阪), 眼球シールドを用いた際の線量分布について検討した, Domestic conference
    Oral presentation

  • 膵臓癌に対する統合的・粒子線治療の開発：吸収性スペーサーを中心に
    Sasaki Ryohei
    第29回山形県放射線科医の会, Jan. 2014, Japanese, 山形県放射線科医の会, 山形国際ホテル, Domestic conference
    Public discourse

  • 明日から取り入れられる緩和ケアの中の放射線療法
    Sasaki Ryohei
    第67回兵庫緩和ケア研究会, Jan. 2014, Japanese, 兵庫緩和ケア研究会, 生田神社会館, Domestic conference
    Public discourse

  • みんなの中にある放射線療法：これからの展開と課題
    Sasaki Ryohei
    中播磨地域がん診療連携拠点病院 医療従事者向け講演会/第4回 放射線治療に関する研修会, Jan. 2014, Japanese, 姫路医療センター, Domestic conference
    Public discourse

  • 高齢子宮頸癌患者に対する根治的放射線治療の経験
    Yoshida Kenji, Miyawaki Daisuke, Ejima Yasuo, 西村英輝, 岡本欣晃, Ebina Yasuhiko, Sasaki Ryohei
    第55回日本婦人科腫瘍学会学術講演会, Dec. 2013, Japanese, 日本婦人科腫瘍学会, 京都府、京都（ウェスティン都ホテル京都）, Domestic conference
    Public symposium

  • 頭頸部癌に対するセツキシマブ併用放射線治療の初期経験
    下山真介, Uezono Haruka, 松尾圭朗, ノルシャズリナ, 松本葉子, Miyawaki Daisuke, Yoshida Kenji, Ejima Yasuo, Sasaki Ryohei, Kiyota Naomi, Ohtsuki Naoki, Nibu Ken-ichi
    第305回公益社団法人日本医学放射線学会関西地方会, Nov. 2013, Japanese, 日本医学放射線学会関西地方会, 大阪(ブリーゼプラザ), Domestic conference
    Oral presentation

  • 眼球シールドによって放射線障害を低減しえた眼瞼周囲皮膚癌の2例
    丸山晃司, Ejima Yasuo, 松尾圭朗, ノルシャズリナ, 松本葉子, Uezono Haruka, Miyawaki Daisuke, Sasaki Ryohei
    第54回関西若手放射線治療研究会, Nov. 2013, Japanese, 関西若手放射線治療研究会, 大阪（大阪狭山市）, 眼球シールドによって放射線障害を低減しえた眼瞼周囲皮膚癌の2例, Domestic conference
    Oral presentation

  • 放射線療法後に長期経過観察した上咽頭癌症例における晩期有害反応の検討
    Sasaki Ryohei, Miyawaki Daisuke, Yoshida Kenji, 西村英輝, 岡本欣晃, Ejima Yasuo, Yamashita Daisuke, Hasegawa Shingo, Ohtsuki Naoki, Nibu Ken-ichi
    日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森（ホテル青森、リンクステーションホール青森）, Domestic conference
    Oral presentation

  • 放射線治療を展開するトランスレーショナルリサーチ
    Sasaki Ryohei
    第273回川崎医学会講演会, Oct. 2013, Japanese, 川崎医学会, 岡山, Domestic conference
    [Invited]
    Invited oral presentation

  • 転移性脳腫瘍に対する全脳照射の検討
    Uezono Haruka, Ejima Yasuo, 松尾圭朗, ノルシャズリナ, 松本葉子, Miyawaki Daisuke, Yoshida Kenji, Sasaki Ryohei
    日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森（ホテル青森、リンクステーションホール青森）, Domestic conference
    Poster presentation

  • 中・下咽頭扁平上皮癌に対する放射線治療後の甲状腺機能低下症に関する検討
    Miyawaki Daisuke, Ejima Yasuo, Yoshida Kenji, Uezono Haruka, 西村英輝, 岡本欣晃, 酒井英郎, Kiyota Naomi, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森（ホテル青森、リンクステーションホール青森）, Domestic conference
    Oral presentation

  • 脊椎転移による脊椎損傷リスクの検討
    Ejima Yasuo, Kakutani Kenichiro, Sakai Yoshitada, Yoshida Kenji, Miyawaki Daisuke, Uezono Haruka, Hara Hitomi, 秋末敏広, Nishida Kotaro, Sasaki Ryohei
    日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森（ホテル青森、リンクステーションホール青森）, Domestic conference
    Poster presentation

  • 小児Gliomaに対する放射線治療の経験
    松尾圭朗, Yoshida Kenji, Miyawaki Daisuke, Uezono Haruka, Ejima Yasuo, ノルシャズリナ, 松本葉子, Sasayama Takashi, 早川昌, Sasaki Ryohei
    日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森（ホテル青森、リンクステーションホール青森）, Domestic conference
    Poster presentation

  • スペーサー手術と粒子線照射による腹部・骨盤部悪性腫瘍の治療
    Fukumoto Takumi, Kito Masahiro, Takebe Atsushi, Tanaka Motofumi, Kuramitsu Kaori, Kinoshita Hisoka, 小松 昇平, Matsumoto Ippei, Ajiki Tetsuo, 出水 祐介, 不和 信和, Sasaki Ryohei, Ku Yonson
    第51回日本癌治療学会学術集会, Oct. 2013, Japanese, 日本癌治療学会, 京都, Domestic conference
    Oral presentation

  • T1／2声門上癌に対する放射線治療成績の検討
    松本葉子, Yoshida Kenji, Uezono Haruka, Miyawaki Daisuke, Ejima Yasuo, 西村英輝, Sasaki Ryohei, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森（ホテル青森、リンクステーションホール青森）, Domestic conference
    Oral presentation

  • Salvage radiotherapy for patients with PSA failure after radical prostatectomy
    ノルシャズリナ, Yoshida Kenji, Miyawaki Daisuke, Ejima Yasuo, Uezono Haruka, 松尾圭朗, 松本葉子, 西村英輝, Furukawa Jyunya, Fujisawa Masato, Sasaki Ryohei
    日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森（ホテル青森、リンクステーションホール青森）, Domestic conference
    Poster presentation

  • 笑顔をとりもどすためのがん治療ー最新の放射線療法のすべてー
    Sasaki Ryohei
    いきいきライフセミナー, Sep. 2013, Japanese, 兵庫県予防医学協会／神戸新聞社, 神戸、兵庫（神戸新聞松方ホール）, Domestic conference
    Oral presentation

  • がんの放射線療法総論
    Sasaki Ryohei
    第7回日本癌治療学会アップデート教育コース, Sep. 2013, Japanese, 日本癌治療学会, 神戸、兵庫（神戸国際会議場）, Domestic conference
    Oral presentation

  • Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: Comparison between Concurrent Chemoradiotherapy and Radiation Therapy Alone
    Miyawaki Daisuke, Yoshida Kohsuke, Ejima Yasuo, H Nishimura, NS Sulaiman, Kiyota Naomi, Saito Miki, N Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, International conference
    Poster presentation

  • Normal tissue tolerance of microplanar beam X-ray : A long-term observation
    N Mukumoto, Miyawaki Daisuke, H Akasaka, M Nakayama, Miura Yasushi, K Umetani, N Nariyama, K Shinohara, T Kondoh, Sasaki Ryohei
    55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, International conference
    Poster presentation

  • Impact of Symptom Rescue by Fractionated Radiotherapy for Rare Angiogenetic Neoplasm of the Abdomen, Vertebra, and Head and Neck Regions
    Y Matsuo, Yoshida Kohsuke, Miyawaki Daisuke, Ejima Yasuo, NS Sulaiman, Kojima Yasutaka, Yamaguchi Masato, Sugimoto Koji, Sasaki Ryohei
    55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, Because of the rarity, a standard treatment for the adult vascular malformation occurred outsides the scalp has not been established. In our institution, the fractionated radiotherapy was successfully applied to the adult vascular malformation of the abdomen, vertebra, and head and neck regions. Here, we retrospectively evaluated our experience and propose a standard of care of, International conference
    Poster presentation

  • Functional outcomes of the facial nerve after post operative radiation therapy for high risk parotid gland malignancies underwent radical surgery with facial nerve resection and reconstructive surgery.
    O Muraoka, H Nishimura, Miyawaki Daisuke, Yoshida Kohsuke, Ejima Yasuo, Y Okamoto, K Hashikawa, N Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, The effect of postoperative radiation treatment (PORT) for facial nerve reconstruction is not fully investigated. The purpose of this study is to evaluate the outcomes of patients treated with the combination of surgery and PORT.Between 2000 and 2009, 27 patients with parotid gland carcinomas were treated with curative surgery and PORT. Nineteen patients received facial nerve s, International conference
    Poster presentation

  • Efficacy of Salvage Radiotherapy in Men with Biochemical Recurrence After Radical Prostatectomy: A Comparison with Endocrine Therapy
    Nor Shazrina Sulaiman, Yoshida Kohsuke, Miyawaki Daisuke, Ejima Yasuo, H Nishimura, Furukawa Jyunya, Fujisawa Masato, Sasaki Ryohei
    55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, Most of the recurrences after radical prostatectomy (RP) are detected only by a rise in the prostate-specific antigen (PSA) level without a radiographic recurrence site. For such men it is unknown whether salvage radiotherapy (SRT) to the prostate bed confers a survival benefit compared with systemic therapy. The standard treatment for PSA failure after RP has not yet been dete, International conference
    Poster presentation

  • A Novel Radiosensitizor of the Functional Food Component, Monogalactosyl diacylglycerol (MGDG) from Spinach, Enhanced the Cytotoxic Effects for the Pancreatic Cancer In Vitro and In Vivo
    H Akasaka, Sasaki Ryohei, N Mukumoto, M Nakayama, NS Sulaiman, Miyawaki Daisuke, Yoshida Kohsuke, Ejima Yasuo, Y Mizushina
    55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, MGDG, a major chloroplast membrane galactolipid extracted from spinach, has been reported as a potent inhibitor of DNA replication and repair. The purpose of the current study is to test whether the MGDG might increase the cytotoxic effects of GEM or radiotherapy (IR) in vitro and in vivo by using human pancreas cancer cell lines., International conference
    Poster presentation

  • A Novel method of Radioprotection for the Gastointestinal System: Efficacy of the Reduced form of Coenzyme Q10.
    Sasaki Ryohei, Nelly, N Mukumoto, H Akasaka, Nor Shazrina Sulaiman, Miyawaki Daisuke, Yoshida Kohsuke, Ejima Yasuo
    55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, International conference
    Poster presentation

  • 頭頸部IMRTの共通プロトコール化と共同研究向けて
    Ejima Yasuo, 下山真介, 松尾圭朗, ノルシャズリナ, 松本葉子, Uezono Haruka, Miyawaki Daisuke, Yoshida Kenji, Sasaki Ryohei
    第38回神戸放射線腫瘍懇話会, Aug. 2013, Japanese, 神戸放射線腫瘍懇話会, 神戸、兵庫（神戸大学医学部附属病院）, Domestic conference
    Oral presentation

  • 進行膵癌に対する各種高精度放射線治療装置の線量分布の比較
    馬屋原博, 原田文, 西村英輝, 尾方俊至, 中山雅央, 上原和之, 松尾圭朗, Ejima Yasuo, Sasaki Ryohei, 藤井正彦
    第38回神戸放射線腫瘍懇話会, Aug. 2013, Japanese, 神戸放射線腫瘍懇話会, 神戸、兵庫（神戸大学医学部附属病院）, Domestic conference
    Oral presentation

  • Clinicopathologic Analysis of Salivary Duct Carcinoma in 15 Japanese Patients
    Yoshinori Imamura, Kiyota Naomi, Naoki Otsuki, Itoh Tomoo, Chihoko Hirai, Takanobu Shimada, Yamashita Daisuke, Sasaki Ryohei, Nibu Ken-ichi, Mukohara Toru, Minami Hironobu
    第11回日本臨床腫瘍学会学術集会, Aug. 2013, English, 日本臨床腫瘍学会, 仙台, We hereby reported a clinicopathologic analysis of 15 Japanese patients with SDC., Domestic conference
    Poster presentation

  • 髄膜腫に対する放射線治療の経験
    松尾圭朗, Yoshida Kenji, Uezono Haruka, Miyawaki Daisuke, Ejima Yasuo, ノルシャズリナ, 松本葉子, Sasaki Ryohei
    第53回JROG, Jul. 2013, Japanese, JROG, 神戸、兵庫（神戸低侵襲がん医療センター）, Domestic conference
    Oral presentation

  • 「放射線療法の進歩と現状」～IMRTと粒子線治療を中心に～
    Sasaki Ryohei
    兵庫県耳鼻咽喉科医会総会, Jul. 2013, Japanese, 兵庫県耳鼻咽喉科医会, 神戸、兵庫（ANAクラウンプラザホテル神戸）, Domestic conference
    [Invited]
    Invited oral presentation

  • 頸部リンパ節転移を認めた原発不明悪性黒色腫の2例
    米澤宏一郎, Morimoto Koichi, Yamashita Daisuke, 谷本 均, Saito Miki, Ohtsuki Naoki, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, 原発不明癌頸部リンパ節転移の約80％が扁平上皮癌であり、悪性黒色腫の頻度は0．9％と非常に稀である。今回我々は頸部リンパ節にのみ転移を認めた原発不明悪性黒色腫の2症例を経験した。症例1は72歳男性。2005年9月に左顎下部腫瘤を主訴に来院し、同部よりの穿刺吸引細胞診で悪性黒色腫の診断が得られた。原発巣は明らかでなく、左顎部敦清術を行った。転移リンパ節は1個であったが節外浸潤を認めたため、術後化学療法としてDAV（Dacarbazine, Nimustine, Vincristine)を8コース施行した。現在術後6年経過し、再発・転移を認めない。症例2は61歳男性。症例1と同様に原発不明悪性黒色腫の診断で左顎部敦清術を行った。多発リンパ節転移と節外浸潤を認めたため、術後にDAVを8コース施行した。現在術後2年経過し、再発・転移を認めない。原発不明悪性黒, Domestic conference
    Oral presentation

  • 放射線治療に役立つFDG-PET：放射線腫瘍医の視点
    Sasaki Ryohei
    第56回兵庫県核医学研究会, Jun. 2013, Japanese, 兵庫県核医学研究会, 神戸、兵庫, Domestic conference
    Oral presentation

  • 鼻腔腫瘍の治療計画における不均質補正の影響
    椋本成俊, Yoshida Kenji, 赤坂浩亮, Ejima Yasuo, Miyawaki Daisuke, Uezono Haruka, Sasaki Ryohei, Ohtsuki Naoki, Nibu Ken-ichi
    第304回公益社団法人日本医学放射線学会関西地方会（第376回レントゲンアーベント）, Jun. 2013, Japanese, 公益社団法人日本医学放射線学会関西地方会, 大阪、ホテルエルセラーン大阪, Domestic conference
    Oral presentation

  • 鼻腔原発NK／T細胞リンパ腫に対する放射線治療経験
    原田 文, Miyawaki Daisuke, 西村英輝, Ejima Yasuo, Yoshida Kenji, Yakushijin Kimikazu, Matsuoka Hiroshi, Doi Kiyoshi, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Poster presentation

  • 頭頸部扁平上皮癌に対する放射線治療後の甲状腺機能低下症に関する検討
    Miyawaki Daisuke, Yoshida Kenji, Ejima Yasuo, 西村英輝, 岡本欣晃, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Poster presentation

  • 頭頚部傍神経節腫に対する放射線治療の経験
    酒井徹也, Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, Uezono Haruka, 松本葉子, ノルシャズリナビンティスライマン, 松尾圭朗, Sasaki Ryohei, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki
    第304回公益社団法人日本医学放射線学会関西地方会（第376回レントゲンアーベント）, Jun. 2013, Japanese, 公益社団法人日本医学放射線学会関西地方会, 大阪、ホテルエルセラーン大阪, Domestic conference
    Oral presentation

  • 当院における唾液腺導管癌15例の臨床病理学的特徴
    今村 善宣, Kiyota Naomi, Ohtsuki Naoki, 島田 貴信, Yamashita Daisuke, Sasaki Ryohei, Nibu Ken-ichi
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 東京, 当院におけるSDC 15例の臨床病理学的特徴を報告した。, Domestic conference
    Poster presentation

  • 当院におけるT3喉頭癌の放射線治療の経験
    松尾圭朗, Yoshida Kenji, Miyawaki Daisuke, Ejima Yasuo, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Oral presentation

  • 前立腺全摘術後のPSA再発に対する救済放射線治療の検討
    ノルシャズリナビンティスライマン, Yoshida Kenji, Miyawaki Daisuke, Ejima Yasuo, Uezono Haruka, 松尾圭朗, 西村英輝, Sasaki Ryohei, Furukawa Jyunya, Fujisawa Masato
    第304回公益社団法人日本医学放射線学会関西地方会（第376回レントゲンアーベント）, Jun. 2013, Japanese, 公益社団法人日本医学放射線学会関西地方会, 大阪、ホテルエルセラーン大阪, Domestic conference
    Oral presentation

  • 進行舌癌に対する術後放射線治療の経験
    Yoshida Kenji, Miyawaki Daisuke, Ejima Yasuo, 西村英輝, Kiyota Naomi, Minamikawa Tsutomu, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Poster presentation

  • 耳下腺癌／顎下腺癌術後症例に対する放射線治療の検討
    村岡 修, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, Ejima Yasuo, Ohtsuki Naoki, Morimoto Koichi, Yamashita Daisuke, Nibu Ken-ichi, 岡本欣晃, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Poster presentation

  • 再発・転移頭頸部がんに対するドセタキセル・シスプラチン併用（DC）療法
    島田貴信, Kiyota Naomi, 今村善宣, Morimoto Koichi, Saito Miki, 西村英輝, Sasaki Ryohei, Ohtsuki Naoki, Nibu Ken-ichi
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Oral presentation

  • 甲状腺原発MALTリンパ腫の治療経験
    Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, 西村英輝, 岡本欣晃, 副島俊典, Matsuoka Hiroshi, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Poster presentation

  • 顎下腺脱分化型腺様嚢胞癌の1例
    入谷啓介, 福田有里子, Ohtsuki Naoki, Nibu Ken-ichi, ノルシャズリナビンティスライマン, Yoshida Kenji, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Oral presentation

  • T1／2声門上癌に対する放射線治療成績の検討
    松本葉子, Yoshida Kenji, Ejima Yasuo, Miyawaki Daisuke, 西村英輝, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Kiyota Naomi, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Poster presentation

  • Flattening Filter Freeビームを用いた体幹部定位放射線治療の検討
    上原和之, 尾方俊至, 中山雅央, 岡山貴宣, 桝谷隆史, 西村英輝, 馬屋原博, 原田 文, 藤井正彦, Sasaki Ryohei, Ejima Yasuo, Uezono Haruka
    第304回公益社団法人日本医学放射線学会関西地方会（第376回レントゲンアーベント）, Jun. 2013, Japanese, 公益社団法人日本医学放射線学会関西地方会, 大阪、ホテルエルセラーン大阪, Domestic conference
    Oral presentation

  • 5年以上経過観察した上咽頭癌症例に関する放射線療法の晩期有害反応の検討
    Sasaki Ryohei, Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, 西村英輝, 岡本欣晃, Yamashita Daisuke, Hasegawa Shingo, Ohtsuki Naoki, Nibu Ken-ichi
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Oral presentation

  • 神戸大学におけるI‐125密封小線源永久挿入療法の治療成績
    Muramaki Mototsugu, Furukawa Jyunya, Tanaka Kazushi, Miyake Hideaki, Yoshida Kenji, Sasaki Ryohei, Sugimura Kazuro, Fujisawa Masato
    第101回日本泌尿器科学会総会, Apr. 2013, Japanese, 日本泌尿器科学会総会, 札幌, Domestic conference
    Oral presentation

  • Roles of FDG-PET for Non-Small-Cell Lung Cancer
    Sasaki Ryohei, R Komaki
    37th Annual MD Anderson Radiation Oncology/Gilbert H. Fletcher Society Meeting, Apr. 2013, English, MD Anderson Radiation Oncology/Gilbert H. Fletcher Society, Kyoto, Japan, International conference
    Oral presentation

  • Radiotherapy for Japanese Elderly Patients with Cervical Cancer
    Yoshida Kohsuke, Miyawaki Daisuke, H Nishimura, Ejima Yasuo, Nakabayashi Koji, Ebina Yasuhiko, Sasaki Ryohei
    37th Annual MD Anderson Radiation Oncology/Gilbert H. Fletcher Society Meeting, Apr. 2013, English, MD Anderson Radiation Oncology/Gilbert H. Fletcher Society, Kyoto, Japan, International conference
    Poster presentation

  • 新規体内吸収性PGA spacerの基礎研究開発
    赤坂浩亮, Sasaki Ryohei, Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, 椋本成俊, 出水祐介, 村上昌雄, 山田 滋, 不破信和, Fukumoto Takumi
    第17回兵庫粒子線治療研究会のご案内, Mar. 2013, Japanese, 兵庫粒子線治療研究会, 兵庫（生田神社会館）, 【目的】重要臓器と近接しているために粒子線・放射線治療が難しい疾患に対する新たな治療法の開発のため、スペーサーをマウス腹部に留置し、毒性を含む生物学的反応とスペーサーの有用性を検討する。【方法】スペーサーをマウス腹部に留置し、一定の観察期間後、スペーサーが生体に及ぼす毒性に関して全血を採取し生化学検査により評価した。また、スペーサーを留置したマウスに対して炭素線を用いた照射実験を行い、スペーサーの有用性を検討した。【結果】採血によるスペーサーの毒性評価では、肝臓、腎臓、膵臓など主要臓器機能に明らかな異常値は認められなかったが、採取可能な血液が少ないことから、無毒性という確定できなかった。照射後の体重の変化を検討したが、スペーサーによる腸管への線量低減効果が示唆された。組織学的検討ではスペーサー周囲に炎症細胞浸潤が認められた。, Domestic conference
    Oral presentation

  • Ten Year Experience with Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Oropharynx
    Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, Ejima Yasuo, Kiyota Naomi, Saito Miki, N Otsuki, Nibu Ken-ichi, Sugimura Kazuro, Sasaki Ryohei
    European Congress of Radiology（ECR, Mar. 2013, English, European Society of Radiology, Austria,Vienna, Purpose/Objective(s): To assess the efficacy of radiation therapy for Squamous cell carcinomas of oropharynx at Kobe University Hospital retrospectively.Materials/Methods: Between July 2000 and March 2011, 98 patients with squamous cell carcinomas of the, International conference
    Poster presentation

  • Radiotherapy for Japanese elderly patients with cervical cancer
    Yoshida Kohsuke, Miyawaki Daisuke, H Nishimura, Nakabayashi Koji, Ebina Yasuhiko, Sugimura Kazuro, Sasaki Ryohei
    European Congress of Radiology（ECR, Mar. 2013, English, European Society of Radiology, Austria,Vienna, Purpose: The purpose of this study was to evaluate the survival outcomes for Japanese elderly patients with cervical cancer treated with radiotherapy (RT).Methods: Fifty-five patients ≥ 75 years old with cervical cancer who were treated with RT were evaluated. Of these 55 patients, 30 were classified as FIGO stage I or II and 25 as stage III or IVA. Two patients had adenocarcin, International conference
    Poster presentation

  • 特発性眼窩炎症に対する治療経験
    原田 文, Miyawaki Daisuke, Yoshida Kenji, Ejima Yasuo, 西村英輝, Sasaki Ryohei, Nagai Takayuki, 安積 淳
    第303回日本医学放射線学会関西地方会（第375回レントゲンアーベント）, Feb. 2013, Japanese, 日本医学放射線学会関西地方会, 大阪（ブリーゼプラザ小ホール）, Domestic conference
    Oral presentation

  • 成人型頭蓋外血管腫・血管奇形の放射線治療
    松尾圭朗, 小島芳夫, Yoshida Kenji, Miyawaki Daisuke, 西村英輝, 村岡 修, 原田 文, ノル シャズリナ, ビンティ スライマン, 松本葉子, Ejima Yasuo, Sasaki Ryohei, Yamaguchi Masato
    第303回日本医学放射線学会関西地方会（第375回レントゲンアーベント）, Feb. 2013, Japanese, 日本医学放射線学会関西地方会, 大阪（ブリーゼプラザ小ホール）, Domestic conference
    Oral presentation

  • 若年者のgliomaに対する放射線治療の経験
    隅野靖彬, Yoshida Kenji, Ejima Yasuo, Miyawaki Daisuke, 西村英輝, ノル シャズリナ, ビンティ スライマン, 原田 文, 村岡 修, Sasaki Ryohei, Sasayama Takashi
    第303回日本医学放射線学会関西地方会（第375回レントゲンアーベント）, Feb. 2013, Japanese, 日本医学放射線学会関西地方会, 大阪（ブリーゼプラザ小ホール）, Domestic conference
    Oral presentation

  • 目で見て学ぶ放射線療法の有害反応とその対策
    Sasaki Ryohei
    第2回がん放射線療法研修, Dec. 2012, Japanese, がん放射線療法研修, 近畿大学医学部附属病院 大講堂, Efficacy， indication， morbidity of radiotherapy was explained, Domestic conference
    [Invited]
    Invited oral presentation

  • 鼻腔原発NK/T 細胞リンパ腫に対する放射線治療経験
    原田 文, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 村岡 修, ノル シャズリナ, ビンティ スライマン, 松本葉子, Nibu Ken-ichi, Matsuoka Hiroshi, Sasaki Ryohei
    日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京（東京国際フォーラム）, Domestic conference
    Poster presentation

  • 当院における中咽頭扁平上皮癌に対する放射線治療成績
    Miyawaki Daisuke, Yoshida Kenji, 西村英輝, 原田 文, 村岡 修, ノル シャズリナ, ビンティ スライマン, Kiyota Naomi, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京（東京国際フォーラム）, 【目的】当院における中咽頭扁平上皮癌の放射線治療成績を遡及的に検討する。【方法】2000年7月から2011年1月までに当院にて中咽頭扁平上皮癌と診断され、放射線治療を施行した96例を対象とした。年齢の中央値は62歳（31-96歳）、男:女=80:16であった。亜部位は前壁：側壁：後壁：上壁＝24：57：3：12、進展度はT1：T2：T3：T4a：T4b＝6：54：17：10：5、N0：N1：N2a：N2b：N2c：N3＝18：14：6：32：17：9であった。手術は13例に施行され、化学療法の併用は81例（同時併用76例）、処方線量の中央値は70Gy（60-70.8Gy）であった。【結果】経過観察期間の中央値は25.5か月(3-141か月)。3年の全生存割合は76％で、無再発生存割合は66％、局所領域制御割合は70％であった。病期別の3年全生存割合は, Domestic conference
    Poster presentation

  • 大型動物を用いた体内吸収性スペーサーの長期安全性の検討
    Sasaki Ryohei, 赤坂浩亮, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 中山雅央, 椋本成俊, 出水祐介, 村上昌雄, Fukumoto Takumi
    日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京（東京国際フォーラム）, Physicaly and biological experimental outcomes of originally established absorbant spacer was explained, Domestic conference
    Oral presentation

  • 高齢頭頸部癌患者に対する放射線治療の経験 −10 年間の検討−
    Yoshida Kenji, Miyawaki Daisuke, 西村英輝, 岡本欣晃, Ohtsuki Naoki, Nibu Ken-ichi, 副島俊典, Sasaki Ryohei
    日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京（東京国際フォーラム）, 目的 2001年から2010年に神戸大学医学部附属病院において放射線治療が施行された高齢頭頸部癌患者に関する遡及的な検討を行う。対象 75歳以上で根治、術後、及び姑息的局所コントロール目的も含め頸部照射が施行された症例を対象とした。これらについて、患者数の推移や、治療の完遂率等を調査した。結果 症例数は221例であった。うち姑息的局所コントロール目的での照射が46例(21%)であった。年齢は中央値78歳 (75-96歳)で、その内80歳以上は80人で全体の全体の36％であった。男性が164例、女性が58例であった。組織型では扁平上皮癌が最も多く186例、悪性リンパ腫が次いで多く21例、以下癌(分類不能)が6例、腺癌、腺様嚢胞癌が4例ずつであった。原発部位は口腔36例、鼻腔・副鼻腔32例、咽頭57例、喉頭66例、その他が30例と喉頭癌が最も多かった。患, Domestic conference
    Oral presentation

  • 顎下腺癌に対する術後放射線療法の検討
    村岡 修, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 原田 文, ノル シャズリナ, ビンティ スライマン, Ohtsuki Naoki, Nibu Ken-ichi, 岡本欣晃, Sasaki Ryohei
    日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京（東京国際フォーラム）, 顎下腺癌術後症例に対して放射線療法を施行し、良好な治療成績を得た。, Domestic conference
    Poster presentation

  • マイクロスリットビームX 線照射における最適条件の検討
    椋本成俊, Sasaki Ryohei, 赤坂浩亮, 中山雅央, NELLY, 西村英輝, Yoshida Kenji, Miura Yasushi, 梅谷啓二, 近藤 威
    日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京（東京国際フォーラム）, 放射光マイクロスリットビームX 線照射における正常脳組織耐容線量の検討, Domestic conference
    Oral presentation

  • ホウレンソウから抽出した機能性糖脂質MGDG を用いた新規放射線増感剤の研究
    赤坂浩亮, Sasaki Ryohei, NELLY, 高山いずみ, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 中山雅央, 椋本成俊, 水品善之
    日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京（東京国際フォーラム）, Domestic conference
    Poster presentation

  • Redox 制御を介した放射線腸管障害抑制法の基礎的検討
    NELLY, Sasaki Ryohei, 椋本成俊, 赤坂浩亮, 中山雅央, 高山いずみ, 西村英輝, Yoshida Kenji, Miyawaki Daisuke
    日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京（東京国際フォーラム）, Domestic conference
    Oral presentation

  • Outcomes of particle beam radiation therapy for lung metastases
    ノル シャズリナ, ビンティ スライマン, 藤井 收, Miyawaki Daisuke, 出水祐介, 丹羽康江, 寺嶋千貴, 美馬正幸, 村上昌雄, Sasaki Ryohei, 不破信和
    日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京（東京国際フォーラム）, Domestic conference
    Poster presentation

  • HIV陽性患者に発生した悪性腫瘍に対する放射線治療の経験
    水沼優子, Miyawaki Daisuke, 西村英輝, Ejima Yasuo, Yoshida Kenji, 原田 文, 村岡 修, ノル シャズリナ, ビンティ スライマン, Sasaki Ryohei
    日本医学放射線学会関西地方会（第374回レントゲンアーベント）, Nov. 2012, Japanese, 日本医学放射線学会関西地方会（第374回レントゲンアーベント）, 大阪府大阪市クリスタルタワー20階A会議室, 目的： HIV陽性患者に発生した悪性腫瘍3例の治療経験を報告する。症例1:37歳男性 PCNSL疑い。症例2:56歳女性 PCNSL。例3:54歳男性 中咽頭癌。症例1はHAART＋。照射(30Gy/10fr)、症例2はHAART＋。全脳照射(36Gy/20fr)、症例3はHAART＋全頸部・boost照射(70.2Gy/39fr)を施行。3症例とも非感染者と比較して有害反応の早期出現や重篤化は見られず、治療は完遂できた。放射線治療はHIV陽性患者の悪性腫瘍に対する有用な治療手段であると考えるが、線量・照射範囲は慎重に決定する必要がある。まとめ：HIV陽性患者に発生した悪性腫瘍に対する治療経験について報告した。, Domestic conference
    Oral presentation

  • Combination Efficacy of MGMT Promoter Methylation Status and MIB-1 Labeling Index for Pattern of Recurrence in Glioblastoma Treated with Multimodal Treatment
    Uehara Keiichiro, Sasayama Takashi, Miyawaki Daisuke, M Nishihara, Yoshida Kohsuke, H Nishimura, Y Okamoto, Sasaki Ryohei, Sugimura Kazuro
    98th Scientific Assembly and Annual Meeting of The Radiological Society of North America, Nov. 2012, English, The Radiological Society of North America, U.S.A , Chicago, International conference
    Poster presentation

  • Stereotactic Body Radiation Therapy in 95 Patients With Lung Tumors Composed of Ground-glass Opacity (GGO): Results of a Retrospective Multicenter Study
    H Onishi, Y Shioyama, Y Matsumoto, Y Shibamoto, A Miyakawa, G Suzuki, Sasaki Ryohei, Miyawaki Daisuke, Nishimura Yoshihiro, R Ryusuke
    54th ASTRO Annual Meeting, Oct. 2012, English, ASTRO, U.S.A , Boston, Purpose/Objective(s): The popularization of computed tomography (CT) in clinical practice has increased the frequency of discovery of nodular ground-glass opacity (GGO). Surgery has been regarded as the general treatment for tumors composed of mainly GGO, International conference
    Oral presentation

  • Stereotactic Body Radiation Therapy for Lung Cancer in Octogenarians
    Ishihara Takeaki, Yamada Katsumi, M Tanahashi, H Niwa, T Matsui, K Yokomura, Sasaki Ryohei
    54th ASTRO Annual Meeting, Oct. 2012, English, ASTRO, U.S.A , Boston, Abstract Background: This retrospective review evaluated the clinical outcomes of stereotactic body radiotherapy for lung cancer in octogenarians. Methods: Thirty-one patients who were over 80 years old at the time of therapy and 33 lesions, treated betwe, International conference
    Poster presentation

  • Patterns of Local Recurrence and Metachronous Malignancy Following Radiation Therapy for Stage I or II Hypopharyngeal Carcinoma: Role of Close Observation and Multidisciplinary Approach
    H Nishimura, Sasaki Ryohei, Yoshida Kohsuke, Miyawaki Daisuke, Y Okamoto, Kiyota Naomi, Saito Miki, N Otsuki, Nibu Ken-ichi
    54th ASTRO Annual Meeting, Oct. 2012, English, ASTRO, U.S.A , Boston, International conference
    Poster presentation

  • Novel Radiosensitization Through Reactive Oxygen Species Generation Using Titanium Peroxide Nanoparticle Compounds Against Pancreas Cancer
    M Nakayama, Sasaki Ryohei, C Ogino, T Tanaka, M Umetsu, S Ohara, Z Tan, K Sato, C Numako, A Kondo
    54th ASTRO Annual Meeting, Oct. 2012, English, ASTRO, U.S.A , Boston, Purpose/Objective(s):Pancreas cancer is one of the most difficult diseases to treat in spite of several challenges of intensive treatment regimens. To improve outcomes of the disease by radiotherapy, novel strategies to increase effects of radiotherapy sh, International conference
    Poster presentation

  • Involved-Field Radiation Therapy Using Protons or Carbon Ions for N1-2M0 Non-small Cell Lung Cancer: A Retrospective Study
    O Fujii, N Hashimoto, K Terashima, M Mima, Y Demizu, Y Niwa, Sasaki Ryohei, Y Hishikawa, M Abe, M Murakami
    54th ASTRO Annual Meeting, Oct. 2012, English, ASTRO, U.S.A , Boston, Purpose/Objective(s): Limited clinical data exists in the use of involved-field radiotherapy (IFRT) for node-positive lung cancer. The purpose of this study was to analyze the results of IFRT using protons or carbon ions for N1-2M0 non-small cell lung cancer (NSCLC) at Hyogo Ion Beam Medical Center (HIBMC) retrospectively.Materials/Methods: Between April 2003 and March 2011, a, International conference
    Poster presentation

  • Hypofractionated Stereotactic Radiation Therapy for Brain Metastases: Exploration of Adhibition and Key Factors Involved in Local Control Rate
    Ishihara Takeaki, Yamada Katsumi, A Harada, K Isogai, Y Tonosaki, Sasaki Ryohei
    54th ASTRO Annual Meeting, Oct. 2012, English, ASTRO, U.S.A , Boston, Abstract Objective: To evaluate the efficacy and toxicity of hypofractionated stereotactic radio-therapy (HSRT) for brain metastases, and to explore adhibition and the key factors in-volved in local control rate (LC).Methods: We performed a retrospective, International conference
    Poster presentation

  • Efficacy of Surgically Implanted Flexible Spacer in Particle Therapy: A novel strategy Making Temporal Space between Tumor and Adjacent Organs
    H Akasaka, Sasaki Ryohei, Fukumoto Takumi, N Mukumoto, M Nakayama, H Nishimura, Yoshida Kohsuke, Miyawaki Daisuke, S Yamada, M Murakami
    54th ASTRO Annual Meeting, Oct. 2012, English, ASTRO, U.S.A , Boston, Purpose/Objective(s): Particle beams, such as proton and carbon ion beams, have demonstrated an increase in energy deposition with a penetration depth up to a sharp maximum at the end of their range: the so-called Bragg peak phenomenon. With current metho, International conference
    Poster presentation

  • A randomized phase II trial comparing standard pain control with or witout gabapentin for the treatment of pain related radiation-induced mucositis head and neck cancer
    Kataoka Tohru, Kiyota Naomi, Shimada T, Toyoda Masanori, Fujiwara Y, Nibu Ken-ichi, Komori Takahide, Sasaki Ryohei, Mukohara Toru, Minami Hironobu
    European Society of Medical Oncology, 2012, Oct. 2012, English, European Society of Medical Oncology, Viena, A randomized phase II trial comparing standard pain control with or witout gabapentin for the treatment of pain related radiation-induced mucositis head and neck cancer, International conference
    Poster presentation

  • 放射線治療 総論
    Sasaki Ryohei
    全国看護セミナー第19回放射線治療を受けるがん患者の看護ケア, Sep. 2012, Japanese, 日本看護協会出版会, 京都府看護協会看護研修センター, Efficacy， indication， morbidity of radiotherapy was explained, Domestic conference
    [Invited]
    Invited oral presentation

  • 頭頸部粘膜悪性黒色腫に対する粒子線治療成績：陽子線治療と炭素治療の比較
    出水祐介, 金東村, 橋本直樹, 荒屋正幸, 高木 克, 美馬正幸, 寺嶋千貴, 藤井 収, 丹羽康江, Morimoto Koichi, Sasaki Ryohei, 村上昌雄, 不破信和
    第37回神戸放射線腫瘍懇話会, Aug. 2012, Japanese, 神戸放射線腫瘍懇話会, 神戸（神戸大学医学部）, Domestic conference
    Oral presentation

  • 食道小細胞癌に対する治療経験
    松本葉子, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 原田 文, 村岡 修, ノル シャズリナ, ビンティ スライマン, Sasaki Ryohei
    第37回神戸放射線腫瘍懇話会, Aug. 2012, Japanese, 神戸放射線腫瘍懇話会, 神戸（神戸大学医学部）, Domestic conference
    Oral presentation

  • Radiation therapy for brainstem gliomas in children and adults
    Yoshida Kohsuke, NS Sulaiman, H Nishimura, Miyawaki Daisuke, Uehara Keiichiro, Sasayama Takashi, Hayakawa Akira, Sugimura Kazuro, Sasaki Ryohei
    The 14th Asian Oceanian Congress of Radiology, Aug. 2012, English, The 14th Asian Oceanian Congress of Radiology, Australia,Sydney, Purpose: The purpose of this study is to evaluate the outcomes of radiation therapy for brainstem gliomas both in children and adults.Methods: Between 1990 and 2010, 25 patients with brainstem gliomas were treated with radiotherapy. Thirteen were children with a median age of 8 years old (Range: 2 – 18 years old) and 12 were adults with a median age of 56 years old (Range: 29 –, International conference
    Poster presentation

  • 喉頭原発悪性リンパ腫に対する放射線治療の経験
    井上由子, Yoshida Kenji, Miyawaki Daisuke, 西村英輝, 原田 文, 村岡 修, ノル シャズリナ, ビンティ スライマン, 岡村篤夫, Saito Miki, Nibu Ken-ichi, Sasaki Ryohei
    日本医学放射線学会関西地方会（第373回レントゲンアーベント）, Jul. 2012, Japanese, 日本医学放射線学会関西地方会（第373回レントゲンアーベント）, 大阪府大阪市（ホテルエルセラーン大阪）, Domestic conference
    Oral presentation

  • 過酸化チタンナノ粒子による放射線増感の検討
    中山雅央, Sasaki Ryohei, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 赤坂浩亮, 椋本成俊, 村岡 修, 原田 文, ノル シャズリナ, ビンティ スライマン, 上原和之, 田中 勉, 荻野千秋, 近藤昭彦
    日本医学放射線学会関西地方会（第373回レントゲンアーベント）, Jul. 2012, Japanese, 日本医学放射線学会関西地方会（第373回レントゲンアーベント）, 大阪府大阪市ホテルエルセラーン大阪, 【目的】我々は過酸化チタンナノ粒子がX線照射により活性酸素種を発生することを見出した。本研究では担癌マウスを用いて同ナノ粒子の放射線増感効果を検討した。【方法】ヒト膵癌細胞MIAPaCa-2を移植したヌードマウスを用いて、ナノ粒子分散液の局注にて、無治療群、ナノ粒子単独群、X線単独群、併用治療群の4群の腫瘍増殖抑制効果を判定した。【結果】治療後43日間の観察期間で、併用群ではX線単独群と比べて有意な腫瘍増殖抑制を認めた。【結論】過酸化チタンナノ粒子の放射線増感効果が判明した。同併用療法が新しい治療法になり得る可能性が示唆された。, Domestic conference
    Oral presentation

  • わかりやすい放射線治療
    Sasaki Ryohei
    第7回関西がんのリハビリテーション研究会, Jul. 2012, Japanese, 関西がんのリハビリテーション研究会, 神戸（神戸大学医学部）, Efficacy， indication， morbidity of radiotherapy was explained, Domestic conference
    [Invited]
    Invited oral presentation

  • Therapeutic Strategies aimed at Laryngeal Preservation of T1-T3N0 Glottic Laryngeal cancer
    A Harada, Sasaki Ryohei, NS Sulaiman, O Muraoka, Miyawaki Daisuke, Yoshida Kohsuke, H Nishimura, Saito Miki, N Otsuki, Nibu Ken-ichi
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, International conference
    Poster presentation

  • Surgically Implanted Flexible Spacer in Particle Therapy:Making Temporal Space between Tumor and Adjacent Organs!
    Sasaki Ryohei, H Akasaka, Fukumoto Takumi, N Mukumoto, H Nishimura, Yoshida Kohsuke, Miyawaki Daisuke, S Yamada, M Murakami
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, Efficacly of originally established absorbant spacer was explained, International conference
    Poster presentation

  • Radiotherapy for Squamous Cell Carcinomas of Oropharynx
    Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, Y Okamoto, Kiyota Naomi, Saito Miki, N Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, Purpose: To assess the efficacy radiation therapy for Squamous cell carcinomas of oropharynx at Kobe University Hospital retrospectively.Methods: Between September 1990 and January 2011, 138 patients with Squamous cell carcinomas of the oropharynx were tr, International conference
    Poster presentation

  • Radiation therapy for brainstem gliomas in children and adults
    Yoshida Kohsuke, NS Sulaiman, H Nishimura, Miyawaki Daisuke, Uehara Keiichiro, Sasayama Takashi, Hayakawa Akira, Sasaki Ryohei
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, Purpose: The purpose of this study is to evaluate the outcomes of radiation therapy for brainstem gliomas both in children and adults.Methods: Between 1990 and 2010, 25 patients with brainstem gliomas were treated with radiotherapy. Thirteen were children, International conference
    Poster presentation

  • Postoperative radiotherapy for the malignant tumors of the parotid gland
    O Muraoka, Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, A Harada, NS Sulaiman, N Otsuki, Nibu Ken-ichi, Y Okamoto, Sasaki Ryohei
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, Postoperative radiotherapy for carcinomas of the parotid gland showed favorable local and regional control., International conference
    Poster presentation

  • Normal tissue tolerance microbeam X-ray irradiation
    N Mukumoto, Sasaki Ryohei, H Akasaka, M Nakayama, Yoshida Kohsuke, H Nishimura, K Umetani, Kondo Takeshi, Miura Yasushi, K Shinohara
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, Normal tissue tolerance microbeam X-ray irradiation, International conference
    Poster presentation

  • Impact of MGDG Promoter Methylation Status and MIB-1 Labeling Index on Recurrence Pattern after Multimodal Treatment in Glioblastoma
    Uehara Keiichiro, Sasayama Takashi, Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, Y Okamoto, M Nishihara, Sugimura Kazuro, Sasaki Ryohei
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, International conference
    Poster presentation

  • Hypofractionated stereotactic radiotherapy for brain metastases:Exploration of adhibition and key factors involved in local control rate
    Ishihara Takeaki, Yamada Katsumi, A Harada, K Isogai, Y Tonosaki, Sasaki Ryohei
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, Abstract Objective: To evaluate the efficacy and toxicity of hypofractionated stereotactic radio-therapy (HSRT) for brain metastases, and to explore adhibition and the key factors in-volved in local control rate (LC).Methods: We performed a retrospective, International conference
    Poster presentation

  • Evaluation of Newly Developed Nanoparticles on Radiosensitization Effect in Pancreas Cancer Tumor Models
    M Nakayama, Sasaki Ryohei, C Ogino, T Tanaka, M Umetsu, S Ohara, Z Tan, K Sato, C Numako, A Kondo
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, Purpose: Titanium peroxide nanoparticle (TiOxNP) generates reactive oxygen species (ROS) in reactions to X-ray irradiation and enhances cytotoxic effects on pancreas cancer. Here, we show the feature and cytotoxic mechanisms of TiOxNP against pancreas can, International conference
    Poster presentation

  • Clinical results of Particle beam radiation therapy for Lung metastases
    NS Sulaiman, O Fujii, Miyawaki Daisuke, Y Demizu, Y Niwa, K Terashima, M Mima, Sasaki Ryohei, M Murakami, N Fuwa
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, International conference
    Poster presentation

  • Chemoradiotherapy in Patients with Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma
    H Nishimura, Yoshida Kohsuke, Miyawaki Daisuke, M Oda, Okuno Tatsuya, Kiyota Naomi, A Harada, O Muraoka, NS Sulaiman, Sasaki Ryohei
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, International conference
    Poster presentation

  • A Pilot Randomized Trial Comparing Standard Pain Control with or without Gabapentin for the Treatment of Pain Related to Radiation-induced Mucositis in Head and Neck Cancer
    Tomoko Kataoka, Kiyota Naomi, Takanobu Shimada, Meiko Nishimura, Yoshinori Imamura, Chayahara Naoko, Toyoda Masanori, Yohei Funakoshi, Hideo Tomioka, Yutaka Fujiwara, Kenichi Nibu, Takahide Komor, Hideki Nishimura, Sasaki Ryohei, Mukohara Toru, Minami Hironobu
    第10回日本臨床腫瘍学会学術集会, Jul. 2012, Japanese, 日本臨床腫瘍学会, 大阪, Domestic conference
    Oral presentation

  • A Novel Radiosensitizor, Monogalactosyldiacyglycerol(MDGD)from Spinach, Enhanced the Cytotoxicity of Radiotherapy to Pancreatic Cancer
    H Akasaka, Sasaki Ryohei, I Takayama, M Nakahana, NELLY, M Nakayama, Miyawaki Daisuke, Yoshida Kohsuke, H Nishimura, Y Mizushina
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, Background/Purpose: Monogalactosyldiacylglycerol (MGDG), a major chloroplast membrane galactolipid extracted from spinach, has been reported as a potent inhibitor of DNA replication and repair. The purpose of the current study is to test whether the MGDG, International conference
    Poster presentation

  • 頸部リンパ節転移を認めた原発不明悪性黒色腫の2例
    米澤宏一郎, Morimoto Koichi, Yamashita Daisuke, 谷本 均, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Kiyota Naomi, Sasaki Ryohei
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, Domestic conference
    Oral presentation

  • 鼻腔悪性黒色腫に対する大線量小分割法放射線治療の経験
    ノル シャズリナ, ビンティ スライマン, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 原田 文, 村岡 修, 岡本欣晃, Doi Kiyoshi, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, Domestic conference
    Poster presentation

  • 頭頸部粘膜悪性黒色腫に対する粒子線治療成績：陽子線治療と炭素治療の比較
    出水祐介, 橋本直樹, 寺嶋千貴, 美馬正幸, 藤井 収, 丹羽康江, 金 東村, 荒屋正幸, Morimoto Koichi, Sasaki Ryohei, 村上昌雄
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, Domestic conference
    Oral presentation

  • 頭頸部癌患者における放射線性粘膜炎による疼痛に対するガバペンチンのパイロット・ランダム化比較試験
    片岡 智子, Kiyota Naomi, 島田 貴信, 今村 善宣, Chayahara Naoko, Toyoda Masanori, 船越 洋平, 富岡 秀夫, 藤原 豊, Nibu Ken-ichi, Komori Takahide, 西村 英輝, Sasaki Ryohei, Mukohara Toru, Minami Hironobu
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 松江, 放射線粘膜炎に対するガバペンチンの有用性, Domestic conference
    Oral presentation

  • 当院における中咽頭扁平上皮癌に対する放射線治療成績
    Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 原田 文, 村岡 修, ノル シャズリナ, ビンティ スライマン, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, 【目的】当院における中咽頭扁平上皮癌の放射線治療成績を遡及的に検討する。【方法】1990年9月から2011年1月までに当院にて中咽頭扁平上皮癌と診断され、放射線治療を施行した138例を対象とした。年齢の中央値は61歳（31-96歳）、男:女=117:21、経過観察期間の中央値は27か月(3-209か月)であった。亜部位は前壁：側壁：後壁：上壁＝39：77：4：18、進展度はT1：T2：T3：T4＝8：71：26：33、N0：N1：N2：N3＝23：21：80：14であった。手術は33例に施行され、化学療法の併用は112例（同時併用91例）、処方線量の中央値は70Gy（50-76.8Gy）であった。【結果】経過観察期間の中央値は27か月(3-209か月)。3年の全生存割合は73％で、無再発生存割合は65％、局所領域制御割合は73％であった。病期別の3年, Domestic conference
    Oral presentation

  • 多診療科共同で集学的治療を行った頭頸部原発骨軟部肉腫の2例
    島田貴信, Kiyota Naomi, 米澤宏一郎, Doi Kiyoshi, Hasegawa Shingo, 西村英輝, Sasaki Ryohei, Minamikawa Tsutomu, 橋川和信, 田原真一, Nibu Ken-ichi
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 松江, 多診療科連携にて治療した頭頸部肉腫の検討, Domestic conference
    Poster presentation

  • 高齢頭頸部癌患者に対する放射線治療の経験－10年間の検討－
    Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 村岡 修, 原田 文, ノル シャズリナ, ビンティ スライマン, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, 目的 2001年から2010年に神戸大学医学部附属病院において放射線治療が施行された高齢頭頸部癌患者に関する遡及的な検討を行う。対象 75歳以上で根治、術後、及び姑息的局所コントロール目的も含め頸部照射が施行された症例を対象とした。これらについて、患者数の推移や、治療の完遂率等を調査した。結果 症例数は221例であった。うち姑息的局所コントロール目的での照射が46例(21%)であった。年齢は中央値78歳 (75-96歳)で、その内80歳以上は80人で全体の全体の36％であった。男性が164例、女性が58例であった。組織型では扁平上皮癌が最も多く186例、悪性リンパ腫が次いで多く21例、以下癌(分類不能)が6例、腺癌、腺様嚢胞癌が4例ずつであった。原発部位は口腔36例、鼻腔・副鼻腔32例、咽頭57例、喉頭66例、その他が30例と喉頭癌が最も多かった。患, Domestic conference
    Poster presentation

  • 顔面・頭頸部に発生した血管原性腫瘍に対する放射線治療の経験
    Sasaki Ryohei, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, Morimoto Koichi, 米澤宏一郎, Ohtsuki Naoki, Nibu Ken-ichi
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, Efficacy of radiotherapy to Vascular oriented neoplasm was explained, Domestic conference
    Oral presentation

  • 顎下腺癌に対する放射線療法の経験
    村岡 修, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 原田 文, ノル シャズリナ, ビンティ スライマン, Ohtsuki Naoki, 柴田智久, 米澤宏一郎, Morimoto Koichi, Yamashita Daisuke, Nibu Ken-ichi, 岡本欣晃, Sasaki Ryohei
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, 顎下腺癌術後症例に対して放射線療法を施行し、良好な治療成績を得た。, Domestic conference
    Poster presentation

  • T1-T3NO声門癌の喉頭温存を目指した治療方針の検討
    原田 文, Miyawaki Daisuke, Yoshida Kenji, 西村英輝, 村岡 修, ノル シャズリナ, ビンティ スライマン, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, Domestic conference
    Oral presentation

  • AIDS患者の中咽頭扁平上皮癌に対する治療経験
    林 拓二, Fujita Takeshi, Yoshida Kenji, 西村英輝, Sasaki Ryohei, Ohtsuki Naoki, Nibu Ken-ichi
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, Domestic conference
    Oral presentation

  • 放射線治療医が求める呼吸器核医学画像
    Sasaki Ryohei
    第26回呼吸器核医学研究会, Apr. 2012, Japanese, 日本核医学会分科会, 神戸（神戸市医師会館）, Efficacy and method of FDG－PET was explained, Domestic conference
    [Invited]
    Invited oral presentation

  • 脳幹部Gliomaに対する放射線治療の経験
    Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 原田 文, 村岡 修, ノル シャズリナ, ビンティ スライマン, 上原和之, Hayakawa Akira, Sasayama Takashi, Sasaki Ryohei
    第71回日本医学放射線学会総会, Apr. 2012, Japanese, 日本医学放射線学会, 横浜（パシフィコ横浜）, 目的：神戸大学病院での脳幹部腫瘍に対する放射線治療の経験について報告する。対象と方法：1990年から2010年にかけて放射線治療が施行された25例。うち小児13例、成人12例であり、年齢は小児が中央値8歳(2-18歳)、成人が56歳(29-75歳)であった。発生部位は橋を含むものが20例、延髄が3例、中脳が2例であった。組織学的診断が得られたのは10例で全例が神経膠腫系であった。うち3例が小児で、Grade2が1例、Grade3が2例であった。残り7例が成人で、Grade1が1例、Grade3が2例、Grade4が4例であった。放射線治療は1回線量1.8-2.0Gyで、総線量は中央値56Gy(50-70Gy)であった。また総治療期間は中央値43日(37-49日)であった。併用療法としてテモゾロマイドが25例中10例に投与されていた。結果：小児では13, Domestic conference
    Others

  • 転移性肺腫瘍に対する粒子線治療成績の検討
    ノル シャズリナ, ビンティ スライマン, 藤井 収, Miyawaki Daisuke, 丹羽康江, 出水祐介, 寺嶋千貴, 美馬正幸, 橋本直樹, Sasaki Ryohei, 村上昌雄
    第71回日本医学放射線学会総会, Apr. 2012, Japanese, 日本医学放射線学会, 横浜（パシフィコ横浜）, Domestic conference
    Oral presentation

  • 耳下腺癌術後症例に対する放射線療法の経験
    村岡 修, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 原田 文, ノル シャズリナ, ビンティ スライマン, Sasaki Ryohei, Ohtsuki Naoki, Nibu Ken-ichi, 岡本欣晃
    第71回日本医学放射線学会総会, Apr. 2012, Japanese, 日本医学放射線学会, 横浜（パシフィコ横浜）, 耳下腺癌術後症例に対して放射線療法を施行し、良好な局所制御を得た。, Domestic conference
    Others

  • ・前立腺癌患者における小線源療法後の下部尿路症状に対するシロドシンの予防効果を検討する無作為化比較試験
    Muramaki Mototsugu, Furukawa Jyunya, Tanaka Kazushi, Miyake Hideaki, Yoshida Kenji, Sasaki Ryohei, Sugimura Kazuro, Fujisawa Masato
    第100回 日本泌尿器科学会総会, Apr. 2012, Japanese, 日本泌尿器科学会総会, 横浜, Domestic conference
    Poster presentation

  • T1-T3NO声門癌の喉頭温存を目指した治療方針の検討
    原田 文, Sasaki Ryohei, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 村岡 修, ノル シャズリナ, ビンティ スライマン, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki
    第71回日本医学放射線学会総会, Apr. 2012, Japanese, 日本医学放射線学会, 横浜（パシフィコ横浜）, Domestic conference
    Oral presentation

  • 脳幹部腫瘍に対する放射線治療の経験
    ノルシャズリナ スライマン, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 原田文, 村岡修, Sasaki Ryohei
    第300回日本医学放射線学会関西地方会（第372回レントゲンアーベント）, Mar. 2012, Japanese, 日本医学放射線学会関西地方会, ブリーゼプラザ7階小ホール（大阪市）, Domestic conference
    Oral presentation

  • 「新開発した生体吸収性スペーサーの基礎的検討」
    赤坂浩亮, 赤坂 浩亮, Sasaki Ryohei, Sasaki Ryohei, 椋本成俊, 椋本 成俊, 中山 雅央, 中山雅央, 浦出剛史, 浦出 剛史, Miyawaki Daisuke, Ohno Yoshiharu, 西尾渉, Yoshida Kenji, 西村 英輝, 山田滋, Fukumoto Takumi, 山田 滋, Fukumoto Takumi, 村上昌雄, 村上 昌雄
    第16回 兵庫粒子線治療研究会, Mar. 2012, Japanese, 神戸, Domestic conference
    Oral presentation

  • Transcutaneous application of CO2 enhanced radiosensitivity in human malignant histiocytoma cells in vivo
    Onishi Y, Kawamoto Teruya, Ueha T, Hara Hitomi, Fukase N, Toda Madoka, Harada R, Sasaki Ryohei, Kurosaka Masahiro, Akisue Toshihiro
    58th Annual Meeting of the Orthopaedic Research Society, Jan. 2012, English, Orthopaedic Research Society, サンフランシスコ, アメリカ, International conference
    Oral presentation

  • Protein kinase D1 negatively regulates invasion and migration ability of human osteosarcoma cells
    Onishi Y, Kawamoto Teruya, Hara Hitomi, Fukase N, Toda Madoka, Harada R, Sasaki Ryohei, Kurosaka Masahiro, Akisue Toshihiro
    58th Annual Meeting of the Orthopaedic Research Society, Jan. 2012, English, Orthopaedic Research Society, サンフランシスコ, アメリカ, International conference
    Oral presentation

  • 嗅神経芽細胞腫の粒子線治療成績の検討
    橋本直樹, 出水祐介, 寺嶋千貴, 藤井収, 丹羽康江, Sasaki Ryohei, 菱川良夫, 阿部光幸, 村上昌雄
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • 頭皮原発血管肉腫のRecursive partitioning analysis (RPA)の検討
    Sasaki Ryohei, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 村岡修, 原田文, ノルシャズリナ スライマン, 中山雅央, 上原和之, Bito Toshinori
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • 当院における前立腺癌小線源治療(ヨード永久刺入)の経験、現状について
    Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 上原和之, 中山雅央, 赤坂浩亮, 椋本成俊, 岡山貴宣, Muramaki Mototsugu, Sasaki Ryohei
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • 低悪性度神経膠腫に対する放射線治療の経験
    ノルシャズリナ スライマン, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 原田文, 村岡修, 上原和之, 中山雅央, Sasaki Ryohei, Sasayama Takashi
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • 体内スペーサーの生体反応と線量分布最適化の研究
    赤坂浩亮, Sasaki Ryohei, Fukumoto Takumi, 山田滋, 椋本成俊, 村岡修, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 村上昌雄
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • 線源種類による前立腺永久刺入療法治療計画への影響に関する検討
    上原和之, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 中山雅央, 赤坂浩亮, 椋本成俊, 岡山貴宣, Muramaki Mototsugu, Sasaki Ryohei
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • 上顎洞平上皮癌に対する放射線治療成績
    Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 原田文, 村岡修, ノルシャズリナ スライマン, 岡本欣晃, Hasegawa Shingo, Nibu Ken-ichi, Sasaki Ryohei
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • 耳下腺癌術後症例に対する放射線療法の経験
    村岡修, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 原田文, ノルシャズリナ スライマン, Ohtsuki Naoki, Nibu Ken-ichi, 岡本欣晃, Sasaki Ryohei
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • 再建遊離空腸に対する術後(化学)放射線療法の検討
    西村英輝, Yoshida Kenji, Miyawaki Daisuke, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki, Kiyota Naomi, 副島俊典, 岡本欣晃, Sasaki Ryohei
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • 過酸化チタンナノ粒子を用いた放射線感受性増感効果の基礎的研究
    中山雅央, Sasaki Ryohei, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 赤坂浩亮, 椋本成俊, 田中勉, 荻野千秋, 近藤昭彦
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • 悪性グリオーマ放射線化学療法後の再発部位の検討
    Sasayama Takashi, 上原 和之, 西原 賢在, 佐々木 眞人, 藤井 収, 副島 俊典, 中溝 聡, 田中 宏知, Mizukawa Katsu, 三宅 茂, Sasaki Ryohei, Kohmura Eiji
    第29回日本脳腫瘍学会学術集会, Nov. 2011, Japanese, 日本脳腫瘍学会, 岐阜, Domestic conference
    Oral presentation

  • マイクロスリットビームX線照射に対する正常脳耐容線量の検討
    椋本成俊, Sasaki Ryohei, 赤坂浩亮, 中山雅央, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 梅谷啓二, 近藤 威, Sugimura Kazuro
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • T1(bulky)ｰT3NO喉頭癌の喉頭温存を目指した治療方法の検討
    原田文, Sasaki Ryohei, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 村岡修, ノルシャズリナ スライマン, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • 脳幹部腫瘍に対する放射線治療の経験
    Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 村岡修, 原田文, ノルシャズリナ スライマン, Sasaki Ryohei, 副島 俊典, 岡本欣晃
    第49回日本癌治療学会, Oct. 2011, Japanese, 日本癌治療学会, 名古屋国際会議場（名古屋市）, Domestic conference
    Oral presentation

  • 当院における進行食道癌の放射線及び化学療法治療の長期予後を踏まえた検討
    池田篤紀, 池田 篤紀, Okuno Tatsuya, Okuno Tatsuya, Imanishi Tatsuya, Imanishi Tatsuya, Nakamura Tetsu, Nakamura Tetsu, 西村英輝, 西村 英輝, Sasaki Ryohei, Sasaki Ryohei, 黒田大介, 黒田 大介, 田村 孝雄, 田村孝雄, Azuma Takeshi
    第49回日本癌治療学会学術集会, Oct. 2011, Japanese, 日本癌治療学会, 名古屋, Domestic conference
    Oral presentation

  • 転移性脳腫瘍に対する分割定位放射線治療の経験
    原田文, 山田和成, Ishihara Takeaki, Yoshida Kenji, 西村英輝, Sasaki Ryohei
    第49回日本癌治療学会, Oct. 2011, Japanese, 日本癌治療学会, 名古屋国際会議場（名古屋市）, Domestic conference
    Oral presentation

  • 精巣腫瘍（seminoma）に対する放射線治療の経験
    ノルシャズリナスライマン, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 村岡 修, 原田文, Sasaki Ryohei, 副島俊典, 岡本欣晃
    第49回日本癌治療学会, Oct. 2011, Japanese, 日本癌治療学会, 名古屋国際会議場（名古屋市）, Domestic conference
    Oral presentation

  • 進行下部直腸癌に対するUFT/LVを用いた術前化学放射線療法第I相試験
    Yamashita Kimihiro, Nakamura Tetsu, 神垣 隆, 高瀬至郎, 西村英輝, Sasaki Ryohei, Kim Kiyonori, 長谷川寛, 松田佳子, 安田貴志, Imanishi Tatsuya, Sumi Yasuo, Suzuki Satoshi, Ku Yonson, 黒田大介
    第49回日本癌治療学会, Oct. 2011, Japanese, 日本癌治療学会, 名古屋国際会議場（名古屋市）, Domestic conference
    Oral presentation

  • 上顎洞扁平上皮癌に対する放射線治療成績
    Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 村岡修, 原田文, ノルシャズリナ スライマン, 中山雅央, 上原和之, 赤坂浩亮, 椋本成俊, Doi Kiyoshi, Yamashita Daisuke, Hasegawa Shingo, Nibu Ken-ichi, Sasaki Ryohei
    第49回日本癌治療学会, Oct. 2011, Japanese, 日本癌治療学会, 名古屋国際会議場（名古屋市）, Domestic conference
    Oral presentation

  • Treatment Outcomes of Particle Radiotherapy Using Protons or Carbon Ions as a Single-Modality Therapy for Adenoid Cystic Carcinoma of the Head and Neck
    Y Demizu, K Terashima, M Mima, O Fujii, Y Niwa, Morimoto Koichi, Sasaki Ryohei, Y Hishikawa, M Abe, M Murakami
    53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conference
    Oral presentation

  • Rituximab prior to local radiotherapy prevents from relapse in ocular adnexal MALT lymphoma
    川野 裕子, Sasaki Ryohei, 橋本 直樹, 若橋 香奈子, 川野 宏樹, 淺田 騰, 定 明子, 皆川 健太郎, Katayama Yoshio, 西村 英輝, Yoshida Kenji, Miyawaki Daisuke, Ejima Yasuo, 安積 淳, Sugimura Kazuro, 松井 利充
    第73回日本血液学会学術集会, Oct. 2011, Japanese, 日本血液学会, 愛知, Domestic conference
    Oral presentation

  • Radiation Therapy For Brain Stem Gliomas In Children And Adults
    Yoshida Kohsuke, H Nishimura, Miyawaki Daisuke, O Muraoka, Uehara Keiichiro, M Nakayama, Sasaki Ryohei, Sugimura Kazuro
    53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conference
    Oral presentation

  • Proton Beam Therapy and Carbon-ion Radiotherapy for T2a-T2bN0M0 Non-small Cell Lung Cancer
    H Iwata, Y Demizu, K Terashima, M Mima, O Fujii, Y Niwa, Miyawaki Daisuke, Sasaki Ryohei, Y Shibamoto, M Murakami
    53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conference
    Oral presentation

  • Microplanar Beams Radiation: Is Brain Really A Serial Organ?
    N Mukumoto, Sasaki Ryohei, H Akasaka, M Nakayama, Miyawaki Daisuke, H Nishimura, K Umetani, T Kondoh, K Shinohara, Sugimura Kazuro
    53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conference
    Oral presentation

  • Long-term Outcome and Patterns of Failure in Primary Ocular Adnexal MALT Lymphoma Treated with Radiotherapy
    N Hashimoto, Sasaki Ryohei, H Nishimura, Yoshida Kohsuke, Miyawaki Daisuke, Y Okamoto, Ejima Yasuo, A Azumi, T Matsui, Sugimura Kazuro
    53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conference
    Oral presentation

  • Histiocytic sarcoma with two immunohistopathologically distinct populations
    Wakahashi Kanako, Kawano Yuko, Kawano Hiroki, Minagawa Kentaro, Sada Akiko, Shimoyama Manabu, Katayama Yoshio, Yoshida Kenji, Sasaki Ryohei, Itoh Tomoo, Yokozaki Hiroshi, Hayashi Yoshitake, Matsui Toshimitsu
    第73回日本血液学会学術集会, Oct. 2011, Japanese, 日本血液学会, 愛知, Domestic conference
    Poster presentation

  • Dosimetric Analysis of Patterns of Failure for High-grade Glioma with Multimodality Treatment: Relationship to MIB-1 Labeling Index
    Uehara Keiichiro, Sasaki Ryohei, Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, M Nakayama, T Soejima, O Fujii, Sasayama Takashi, Sugimura Kazuro
    53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conference
    Oral presentation

  • Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus: A Retrospective Study
    Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, O Muraoka, M Nakayama, Uehara Keiichiro, Hasegawa Shingo, Nibu Ken-ichi, Sugimura Kazuro, Sasaki Ryohei
    53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conference
    Oral presentation

  • Bone Injury after Definitive Radiotherapy for Uterine Cervical Cancer: Retrospective Analysis of Risk Factors
    Uezono Haruka, K Tsujino, K Moriki, Y Matsumoto, F Nagano, Y Ota, Sugimura Kazuro, Sasaki Ryohei, T Soejima
    53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conference
    Oral presentation

  • Radiotherapy for Elderly Patients With Cervical Cancer
    Yoshida Kohsuke, H Nishimura, Miyawaki Daisuke, O Muraoka, A Harada, NS Sulaiman, Nakabayashi Koji, S Yoshida, Sasaki Ryohei, Sugimura Kazuro
    16ｔｈ ECCO, Sep. 2011, English, ECCO, ストックホルム, ドイツ, International conference
    Oral presentation

  • Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus - a Retrospective Study
    Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, O Muraoka, M Nakayama, Uehara Keiichiro, Sugimura Kazuro, Hasegawa Shingo, Nibu Ken-ichi, Sasaki Ryohei
    16ｔｈ ECCO, Sep. 2011, English, ECCO, ストックホルム, ドイツ, International conference
    Oral presentation

  • 当院のおける脳転移に対する分割定位放射線治療
    原田 文, 山田和成, Ishihara Takeaki, Yoshida Kenji, 西村英輝, Sasaki Ryohei
    第20回日本定位放射線治療学会, Jul. 2011, Japanese, 日本定位放射線治療学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 遊離空腸再建後の高リスク頭頸部癌に対する術後放射線治療の検討
    西村英輝, Sasaki Ryohei, Yoshida Kenji, Miyawaki Daisuke, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki, Kiyota Naomi, 岡本欣晃, 副島俊典
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 頭頸部皮膚血管肉腫に対するRecursive partitioning analysis(RPA)の検討
    Sasaki Ryohei, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 村岡修, 橋本直樹, 副島俊典, 藤井 収, Bito Toshinori, Nibu Ken-ichi
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 頭頸部腺様嚢胞癌に対する粒子線(陽子線・炭素線)単独治療成績
    出水陽介, 寺嶋千貴, 美馬正幸, 藤井 収, 丹羽康江, Morimoto Koichi, Miyawaki Daisuke, Sasaki Ryohei, 村上昌雄
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 頭蓋底浸潤を認めた頭頸部癌に対する粒子線治療成績
    Morimoto Koichi, 出水祐介, 寺嶋千貴, 美馬正幸, 藤井 収, 丹羽康江, Miyawaki Daisuke, Sasaki Ryohei, 村上昌雄, Nibu Ken-ichi
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 当科における喉頭機能温存手術の検討
    米澤宏一郎, Morimoto Koichi, Saito Miki, Ohtsuki Naoki, Kiyota Naomi, 西村英輝, Sasaki Ryohei, Nibu Ken-ichi
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 当科における顎下腺癌手術症例の検討
    Ohtsuki Naoki, 柴田智久, 米澤宏一郎, Morimoto Koichi, Yamashita Daisuke, 村岡 修, Miyawaki Daisuke, Yoshida Kenji, 西村英輝, Sasaki Ryohei, Nibu Ken-ichi
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 切除不能頭頸部癌に対するSequential therapyの安全性に関する後向き研究
    島田貴信, Kiyota Naomi, Ohtsuki Naoki, Nibu Ken-ichi, 西村英輝, Sasaki Ryohei
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 上顎洞扁平上皮癌に対する放射線治療成績
    Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 村岡修, 岡本欣晃, Doi Kiyoshi, Yamashita Daisuke, Hasegawa Shingo, Nibu Ken-ichi, Sasaki Ryohei
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 耳下腺癌術後症例に対する放射線治療の経験
    村岡 修, Miyawaki Daisuke, Yoshida Kenji, 西村英輝, 柴田智久, 米澤宏一郎, Morimoto Koichi, Yamashita Daisuke, Ohtsuki Naoki, Nibu Ken-ichi, 岡本欣晃, Sasaki Ryohei
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 局所進行切除不能食道癌（T4/M1LYM）に対する化学放射線療法
    小田麻生, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 村岡修, 原田文, ノルシャズリナ スライマン, Sasaki Ryohei
    第298回日本医学放射線学会関西地方会, Jun. 2011, Japanese, 大阪, Domestic conference
    Oral presentation

  • 局所進行外耳道扁平上皮癌に対する3剤(TPF)併用化学放射線療法の経験
    Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 村岡 修, Sasaki Ryohei, Kiyota Naomi, Doi Kiyoshi, Hasegawa Shingo, Nibu Ken-ichi
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 鼻腔NK/T細胞性リンパ腫に対する放射線治療の経験
    橋本直樹, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 村岡修, 中山雅央, 上原和之, Matsuoka Hiroshi, Nibu Ken-ichi, Sasaki Ryohei
    第70回日本医学放射線学会総会, May 2011, Japanese, 日本医学放射線学会, 震災の影響によりWEB開催, Domestic conference
    Oral presentation

  • 精巣腫瘍（seminoma）に対する放射線治療の経験
    Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 村岡修, 橋本直樹, 中山雅央, 上原和之, 副島俊典, 岡本欣晃, Sasaki Ryohei
    第70回日本医学放射線学会総会, May 2011, Japanese, 日本医学放射線学会, 震災の影響によりWEB開催, Domestic conference
    Oral presentation

  • 原発不明頸部リンパ節転移に対する治療経験
    村岡修, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, 岡本欣晃, Sasaki Ryohei
    第70回日本医学放射線学会総会, May 2011, Japanese, 日本医学放射線学会, 震災の影響によりWEB開催, Domestic conference
    Oral presentation

  • 局所進行外耳道扁平上皮癌に対する3剤（TPF）併用化学放射線療法の経験
    難波富美子, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 橋本直樹, 村岡修, Sasaki Ryohei, Kiyota Naomi, Hasegawa Shingo, Nibu Ken-ichi
    第70回日本医学放射線学会総会, May 2011, Japanese, 日本医学放射線学会, 震災の影響によりWEB開催, Domestic conference
    Oral presentation

  • 1・2期下咽頭癌に対する放射線治療成績の検討
    Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 橋本直樹, 村岡修, 中山雅央, 上原和之, 菊川久美子, Nibu Ken-ichi, Sasaki Ryohei
    第70回日本医学放射線学会総会, May 2011, Japanese, 日本医学放射線学会, 震災の影響によりWEB開催, Domestic conference
    Oral presentation

  • 頭頚部腺様嚢胞癌に対する放射線治療の経験
    片山直人, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 橋本直樹, 村岡 修, Sasaki Ryohei
    第297回 日本医学放射線学会関西地方会, Feb. 2011, Japanese, 大阪（大阪）, Domestic conference
    Oral presentation

  • 放射線療法の副作用とその対策
    Sasaki Ryohei
    がん診療連携拠点病院機能強化事業-放射線療法・化学療法の副作用とその対策-, 2011, Japanese, 神戸, Domestic conference
    Oral presentation

  • 神戸大学における前立腺癌小線源治療－2年半の経験についての検討－
    ノルシャズリナ, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 上原和之, 中山雅央, 赤坂浩亮, 椋本成俊, Sasaki Ryohei, 岡山貴宣, Muramaki Mototsugu
    第36回神戸放射線腫瘍懇話会, 2011, Japanese, 神戸放射線腫瘍懇話会, 神戸大学医学部附属病院（神戸市）, Domestic conference
    Oral presentation

  • 吸収性スペーサーの新規開発における基礎的検討
    赤坂浩亮, Sasaki Ryohei, 椋本成俊, 中山雅央, 上原和之, ネリー, ノルシャズリナ スライマン, 原田文, 村岡修, Miyawaki Daisuke, Yoshida Kenji, 西村英輝, Sugimura Kazuro, Fukumoto Takumi, 前田拓也, 村上昌雄
    第36回神戸放射線腫瘍懇話会, 2011, Japanese, 神戸放射線腫瘍懇話会, 神戸大学医学部附属病院（神戸市）, Domestic conference
    Oral presentation

  • -
    Sasaki Ryohei
    山田班班会議, Jan. 2011, Japanese, 宮城（仙台）, Domestic conference
    Oral presentation

  • 乳がん患者の放射線治療衣の開発
    井上 真理, 佐々木 良平, 河野 誠之, 吉田 賢史, 宮脇 大輔, 岡山 貴宣, 古谷 稔, 大江 周平, 真鍋 巧
    日本繊維機械学会 秋季セミナー, Nov. 2010, Japanese, Domestic conference
    Poster presentation

  • 頭頸部腺様嚢胞癌に対する粒子線(陽子線・炭素線)治療
    出水祐介, 寺嶋千貴, 美馬正幸, 藤井收, 丹羽康江, Miyawaki Daisuke, Sasaki Ryohei, 村上昌雄
    日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conference
    Oral presentation

  • 当院における食道癌放射線治療の遡及的検討
    関井修平, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 上原和之, 中山雅央, 原田 文, 村岡 修, 橋本直樹, Sasaki Ryohei
    第296回日本医学放射線学会関西地方会(第368回レントゲンアーベント), Nov. 2010, Japanese, 大阪医科大学, Domestic conference
    Oral presentation

  • 当院における食道癌に対する化学放射線治療の遡及的検討
    関井修平, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 中山雅央, 上原和之, 岡本欣晃, 副島俊典, Okuno Tatsuya, Sasaki Ryohei
    日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conference
    Oral presentation

  • 当院で放射線治療を施行した悪性神経膠腫の再発形式に関する検討
    Miyawaki Daisuke, 上原和之, 西村英輝, Yoshida Kenji, 原田文, 橋本直樹, 村岡修, 中山雅央, 篠山隆, Sasaki Ryohei
    日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conference
    Oral presentation

  • 局所進行外自動扁平上皮癌に対する3剤（TPF）併用化学放射線療法の経験
    Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 村岡修, 橋本直樹, Sasaki Ryohei, Hasegawa Shingo, Kiyota Naomi, Nibu Ken-ichi
    日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conference
    Oral presentation

  • 眼付属器MALTリンパ腫の放射線治療成績の検討
    橋本直樹, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 原田文, 村岡修, 中山雅央, 上原和之, Ejima Yasuo, Sasaki Ryohei
    日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conference
    Oral presentation

  • ゲムシタビン・放射線併用療法のおけるオートファジーの役割に関する基礎的研究
    Sasaki Ryohei, 椋棒英世, 辻村利明, Ku Yonson, 鈴木陽子, Yoshida Kenji, Miyawaki Daisuke, 西村英輝
    日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conference
    Oral presentation

  • 1・2期下咽頭癌に対する放射線治療成績の検討
    菊川久美子, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 原田文, 橋本直樹, 村岡修, Nibu Ken-ichi, Sasaki Ryohei, Sugimura Kazuro
    日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conference
    Oral presentation

  • 当院における後期高齢者食道癌の内科的及び外科的治療の成績について
    池田 篤紀, Okuno Tatsuya, 三村 卓也, 藤島 佳未, Imanishi Tatsuya, Nakamura Tetsu, 西村 英輝, Sasaki Ryohei, 田村 孝雄, 黒田 大介, Azuma Takeshi
    第48回日本癌治療学会学術集会, Oct. 2010, Japanese, 日本癌治療学会, 京都, Domestic conference
    Oral presentation

  • Radiotherapy for Elderly Patients with Cervical Cancer
    Yoshida Kohsuke, H.Nishimura, Miyawaki Daisuke, T.Kawabe, Y.Okamoto, Nakabayashi Koji, S.Yoshida, Sasaki Ryohei, Sugimura Kazuro
    52nd ASTRO, Oct. 2010, English, サンディエゴ, アメリカ, International conference
    Oral presentation

  • Particle-BeamRadiation Therapy for Skull Base Chordomas:A Retrospective Study
    Miyawaki Daisuke, Y.Demizu, K.Terashima, M.Mima, O.Fujii, Y.Niwa, Yoshida Kohsuke, H.Nishimura, Sasaki Ryohei, M.Murakami
    52nd ASTRO, Oct. 2010, English, サンディエゴ, アメリカ, International conference
    Oral presentation

  • I/II期子宮頚癌に対する 根治的放射線治療の遡及的検討
    Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 河辺哲也, Sasaki Ryohei, Nakabayashi Koji, Morita Hiroki, 吉田茂樹, Yamada Hideto, 岡本欣晃
    第48回日本癌治療学会学術大会, Oct. 2010, Japanese, 京都, Domestic conference
    Oral presentation

  • 1／2 期子宮頸癌に対する根治的放射線治療の遡及的解析
    Yoshida Kenji, 西村 英輝, Miyawaki Daisuke, Sasaki Ryohei, Nakabayashi Koji, Morita Hiroki, 吉田 茂樹, Yamada Hideto, 河辺 哲也, 岡本 欣晃
    第48回日本癌治療学会学術集会, Oct. 2010, Japanese, 日本癌治療学会, 京都, Domestic conference
    Oral presentation

  • 放射線治療に関するトランスレーショナルリサーチ
    Sasaki Ryohei
    第4回慶應義塾大学放射線治療再教育ｺｰｽ「高精度放射線治療の基礎知識再構築」, Sep. 2010, Japanese, 東京, Domestic conference
    Oral presentation

  • がん放射線療法の基礎知識
    Sasaki Ryohei
    2010年度全国看護セミナー, Sep. 2010, Japanese, 京都（京都府看護協会研修センター）, Domestic conference
    Invited oral presentation

  • 臨床的肺癌に対する粒子線治療成績 －stageI症例における遡及的解析－
    藤井 收, 出水祐介, 寺嶋千貴, 美馬正幸, 丹羽康江, 村上昌雄, Miyawaki Daisuke, Sasaki Ryohei
    第35回 神戸放射線腫瘍懇話会, Aug. 2010, Japanese, 神戸, Domestic conference
    Oral presentation

  • 原発不明癌頸部リンパ節転移に対する治療経験
    村岡修, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, Sasaki Ryohei, 河辺哲也, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第35回 神戸放射線腫瘍懇話会, Aug. 2010, Japanese, 神戸, Domestic conference
    Oral presentation

  • Spring-8の白色X線を用いた Microslit beam irradiationの基礎的研究の準備状況と将来展望
    椋本成俊, 赤坂浩亮, 中山雅央, 上原和之, 岩下美里, 橋本直樹, 原田文, 村岡修, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, Sasaki Ryohei, Sugimura Kazuro, 近藤 威
    第35回 神戸放射線腫瘍懇話会, Aug. 2010, Japanese, 神戸, Domestic conference
    Oral presentation

  • 眼付属器リンパ腫の放射線治療成績の検討
    橋本直樹, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 村岡修, 中山雅央, 上原和之, Sasaki Ryohei
    第295回日本医学放射線学会関西地方会, Jul. 2010, Japanese, 大阪, Domestic conference
    Oral presentation

  • 眼付属器MALTリンパ腫に対する放射線治療成績の検討
    Miyawaki Daisuke, 西村英輝, 橋本直樹, Yoshida Kenji, 原田文, 村岡修, Ejima Yasuo, Sugimura Kazuro, Sasaki Ryohei
    平成22年度科学研究費補助金 基盤研究（A）「早期の癌に対する標準的放射線治療方法確立と適応決定に関する研究」 第1回全体会議, Jul. 2010, Japanese, 松島, Domestic conference
    Oral presentation

  • 拡散テンソル画像を用いた悪性繰りおーマに対する強度変調放射線治療の検討
    上原 和之, 中山雅央, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 橋本直樹, 村岡修, Sasaki Ryohei
    第295回日本医学放射線学会関西地方会, Jul. 2010, Japanese, 大阪, Domestic conference
    Oral presentation

  • Vitamin K 新規誘導体を用いた放射線抵抗性の克服に関する基礎研究
    Sasaki Ryohei
    第40回放射線による制癌シンポジウム, Jul. 2010, Japanese, 北海道, Domestic conference
    Oral presentation

  • 1／2 期子宮頸癌に対する根治的放射線治療の遡及的解析
    Yoshida Kenji, 西村 英輝, Miyawaki Daisuke, 河辺 哲也, Sasaki Ryohei, Nakabayashi Koji, Morita Hiroki, 吉田 茂樹, Yamada Hideto, 岡本 欣晃
    第48回日本婦人科腫瘍学会学術集会, Jul. 2010, Japanese, 日本婦人科腫瘍学会, つくば, Domestic conference
    Oral presentation

  • 嗅神経芽細胞腫に対する粒子線治療成績
    Miyawaki Daisuke, 村上昌雄, 出水祐介, 丹羽康江, 寺嶋千貴, 美馬正幸, 西村英輝, Yoshida Kenji, 河邉哲也, Morimoto Koichi, Nibu Ken-ichi, 菱川良夫, Sasaki Ryohei
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 放射線治療医の視点からみた放射線防護
    Sasaki Ryohei
    平成22年度放射線等安全取扱講習会, Jun. 2010, Japanese, 栃木, Domestic conference
    Oral presentation

  • 放射線治療に関連するトランスレーショナルリサーチ
    Sasaki Ryohei
    第4回大阪大学放射線治療セミナー, Jun. 2010, Japanese, 大阪, Domestic conference
    Oral presentation

  • 放射線治療が施行された喉頭悪性リンパ腫の3例
    上園玄, Yoshida Kenji, 西村英輝, 河辺哲也, Miyawaki Daisuke, Ishihara Takeaki, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 同時併用科学放射線療法を行った中咽頭癌患者に対する嚥下リハビリテーションの有用性
    常行美貴, 米澤宏一郎, Morimoto Koichi, Doi Kiyoshi, Hasegawa Shingo, 谷本均, Saito Miki, Ohtsuki Naoki, 清田直臣, Sasaki Ryohei, Nibu Ken-ichi
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 頭頚部原発・髄外性形質細胞腫に対する放射線治療成績の多施設調査研究
    Sasaki Ryohei, 安田耕一, 阿部栄輔, 内田伸江, 河島光彦, 芝本雄太, 加賀美芳和, 塩山善之, 宇野隆, 中田健生, 冨士原将之, 高田佳江
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 当科における耳下腺癌の治療成績
    柴田智久, 米澤宏一郎, Morimoto Koichi, Doi Kiyoshi, Yamashita Daisuke, Hasegawa Shingo, 井上博之, Ohtsuki Naoki, Yoshida Kenji, 西村英輝, Sasaki Ryohei, Nibu Ken-ichi
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 当院における頭頚部腺様囊胞腺癌に対する術後放射線治療の遡及的検討
    Ishihara Takeaki, 西村英輝, Yoshida Kenji, 河辺哲也, Miyawaki Daisuke, 上園玄, Sasaki Ryohei, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 当院における中咽頭癌の放射線治療成績
    河辺哲也, Ishihara Takeaki, Miyawaki Daisuke, Yoshida Kenji, 西村英輝, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 超選択的動注法を用いた化学放射線療法後のsalvage手術後に胸鎖関節骨髄炎を来たし治療に難渋した1症例
    米澤宏一郎, Yamashita Daisuke, 松居秀敏, 柴田智久, Nibu Ken-ichi, Sasaki Ryohei, 田原真也
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 原発不明癌頚部リンパ節転移に対する治療経験
    Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 河辺哲也, Sasaki Ryohei, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Kiyota Naomi, 岡本欣晃
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 下咽頭癌に対する術後放射線治療の遡及的検討
    西村英輝, Yoshida Kenji, 河辺哲也, Miyawaki Daisuke, Nibu Ken-ichi, Saito Miki, Ohtsuki Naoki, Kiyota Naomi, 副島俊典, Sasaki Ryohei
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 鼻腔NK/T cell lymphomaに対する放射線治療
    菊川久美子, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 橋本直樹, 村岡修, Sasaki Ryohei
    第47回JROG, May 2010, Japanese, 大阪, Domestic conference
    Oral presentation

  • 放射線治療が施行された喉頭原発悪性リンパ腫の3例
    Uezono Haruka, Yoshida Kenji, 西村英輝, 河邊哲也, Miyawaki Daisuke, Ishihara Takeaki, Sasaki Ryohei, Sugimura Kazuro
    第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference
    Oral presentation

  • 頭蓋内germ cell tumorに対する放射線治療成績
    河辺哲也, Sasaki Ryohei, Ishihara Takeaki, Uezono Haruka, Miyawaki Daisuke, Yoshida Kenji, 西村英輝, 西原賢在, 岡本欣晃, Kohmura Eiji, Sugimura Kazuro
    第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference
    Oral presentation

  • 頭蓋底脊索腫に対する粒子線治療
    Miyawaki Daisuke, 村上昌雄, 出水祐介, 丹羽康江, 寺嶋千貴, 美馬正幸, Sasaki Ryohei, Sugimura Kazuro, 菱川良夫
    第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference
    Oral presentation

  • 当院における中枢神経原発悪性リンパ腫に対する放射線治療の遡及的検討
    Ishihara Takeaki, Yoshida Kenji, Sasaki Ryohei, 西村英輝, 河辺哲也, Miyawaki Daisuke, Uezono Haruka, 篠山隆, Kohmura Eiji, Sugimura Kazuro
    第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference
    Oral presentation

  • 前立腺がん―早期発見からやさしい治療まで―
    Sasaki Ryohei, 楫 靖, 藤原正人, Takahashi Satoru, 平塚純一
    第69回日本医学放射線学会市民公開講座, Apr. 2010, Japanese, 兵庫, Domestic conference
    Oral presentation

  • 高齢子宮頚癌患者に対する放射線治療の経験
    Yoshida Kenji, Sasaki Ryohei, 西村英輝, 河辺哲也, Miyawaki Daisuke, Uezono Haruka, Ishihara Takeaki, 岡本欣晃, Sugimura Kazuro
    第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference
    Oral presentation

  • 局所進行下咽頭癌に対する術後照射の遡及的検討
    西村英輝, Sasaki Ryohei, Yoshida Kenji, 河辺哲也, Miyawaki Daisuke, Uezono Haruka, Ishihara Takeaki, Nibu Ken-ichi, 副島俊典, Sugimura Kazuro
    第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference
    Oral presentation

  • 教育講演－喉頭癌
    Sasaki Ryohei
    第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference
    Oral presentation

  • 肝細胞癌に対する粒子線治療前TACEの有効性の検討
    寺嶋千貴, 村上昌雄, 美馬正幸, 丹羽康江, 出水祐介, 菱川良夫, Sasaki Ryohei, Miyawaki Daisuke, 小松昇平
    第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference
    Oral presentation

  • 聴器扁平上皮癌に対する治療経験
    Yoshida Kenji, Sasaki Ryohei
    第2回 班会議 科学研究費補助金：山田班 「荷電粒子線を用いたがん治療の標準化と効率化に関する研究」, Feb. 2010, Japanese, 東北大学, 松島, Domestic conference
    Oral presentation

  • 骨転移痛に対するストロンチウム-89の初期使用経験
    末永裕子, Yoshida Kenji, Uezono Haruka, 西村 英輝, 河邊 哲也, Miyawaki Daisuke, Ishihara Takeaki, Sasaki Ryohei, Sugimura Kazuro
    第294回日本医学放射線学会関西地方会, Feb. 2010, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • 胸部食道癌の治療計画における不均質補正の影響
    中山雅央, Sasaki Ryohei, 岡本 欣晃, 西村 英輝, 河邊 哲也, Yoshida Kenji, Miyawaki Daisuke, 上原 和之, Sugimura Kazuro
    第294回日本医学放射線学会関西地方会, Feb. 2010, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • Ｘ線照射と粒子線ブースト照射を用いたcombined modalityによる治療プロトコール作成に関する報告
    西村英輝, Sasaki Ryohei, 出水祐介, 村上昌雄, 太田陽介, 副島俊典
    第14回兵庫粒子線治療研究会, 2010, Japanese, 兵庫（神戸大学医学部附属病院内）, Domestic conference
    Oral presentation

  • Treatment Outcomes of Squamous Cell Carcinoma of External Auditory Canal and Middle Ear
    Yoshida Kohsuke, Sasaki Ryohei, M. Nakabayashi, H. Nishimura, Y. Okamoto, Kawabe T, Hasegawa Shingo, N. Otsuki, Nibu Ken-ichi, Sugimura Kazuro
    51th ASTRO, Nov. 2009, English, シカゴ, アメリカ, International conference
    Oral presentation

  • Significance of Autophagy Induced by Gemcitabine, Radiotherapy, and the Combination of Them against Pancreatic Adenocarcinoma In Vitro and In Vivo
    H. Mukubou, T. Tsujimura, Sasaki Ryohei, Yoshida Kohsuke, Suzuki Yasuaki, Y. Hori, Ku Yonson
    51th ASTRO, Nov. 2009, English, シカゴ, アメリカ, International conference
    Oral presentation

  • Radiotherapy for Locally Advanced Hypopharyngeal Carcinoma - A Comparison between Definitive (Chemo-) Radiotherapy and Laryngectomy followed by Postoperative Radiotherapy
    H. Nishimura, Sasaki Ryohei, Y. Okamoto, Yoshida Kohsuke, Kawabe T, Nibu Ken-ichi, Ohtsuki Naoki, M. Saitoh, T. Soejima, Sugimura Kazuro
    51th ASTRO, Nov. 2009, English, シカゴ, アメリカ, International conference
    Oral presentation

  • Radiation Therapy in Patients with Implanted Cardiac Pacemakers and Implantable Cardio-defibrillators: A Prospective Survey in Japan
    T. Soejima, E. Yoden, Nishimura Yoshihiro, S. Ono, Yoshida Akihiro, H. Fukuda, N. Fukuhara, Sasaki Ryohei, K. Tsujino, Y. Norihisa
    51th ASTRO, Nov. 2009, English, シカゴ, アメリカ, International conference
    Oral presentation

  • Prognostic Significance of HPV infection and P16 Expression: A Strategy for Organ Preservation in Oropharyngeal Squamous Cell Carcinoma
    Y. Ota, T. Soejima, K. Tsujino, O. Fujii, S. Iwae, T. Sudo, C. Ohbayashi, Sasaki Ryohei
    51th ASTRO, Nov. 2009, English, シカゴ, アメリカ, International conference
    Oral presentation

  • Novel Physiological Reaction after Proton Beam Therapy in Patients with Prostate Cancer: Urinary Activation
    M. Shimizu, Sasaki Ryohei, Miyawaki Daisuke, H. Nishimura, Y. Demizu, T. Akagi, D. Suga, M. Murakami, Sugimura Kazuro, Y. Hishikawa
    51th ASTRO, Nov. 2009, English, シカゴ, アメリカ, International conference
    Oral presentation

  • Multi-institutional Analysis of Solitary Extramedullary Plasmacytoma of the Head and Neck Treated with Curative Radiotherapy
    Sasaki Ryohei, Kawabe T, E. Abe, N. Uchida, K. Yasuda, T. Uno, M. Fujiwara, Y. Shioyama, Y. Shibamoto, S. Yamada
    51th ASTRO, Nov. 2009, English, シカゴ, アメリカ, International conference
    Oral presentation

  • 頭蓋底脊索腫に対する粒子線治療
    Miyawaki Daisuke, 村上 昌雄, 出水 祐介, 美馬 正幸, 寺嶋 千貴, 有村 健, 丹羽 康江, Sasaki Ryohei, Sugimura Kazuro, 菱川 良夫
    第47回日本癌治療学会学術大会, Oct. 2009, Japanese, 日本癌治療学会, 横浜, Domestic conference
    Oral presentation

  • 当院における中枢神経原発悪性リンパ腫(PCNSL)の放射線治療経験
    Ishihara Takeaki, Yoshida Kenji, Sasaki Ryohei, 西村 英輝, 河邊 哲也, Miyawaki Daisuke, Uezono Haruka, 上原 和之, 中山 雅央, Sugimura Kazuro, 篠山 隆, Kohmura Eiji
    第293回日本医学放射線学会関西地方会, Oct. 2009, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • 当院での食道表在癌の内科治療と外科治療の治療成績の比較について
    池田 篤紀, Okuno Tatsuya, 藤島 佳未, Morita Yoshinori, Nakamura Tetsu, 西村 英輝, Sasaki Ryohei, 田村 孝雄, 黒田 大介, Toyonaga Takashi, Kutsumi Hiromu, Azuma Takeshi
    第47回日本癌治療学会学術大会, Oct. 2009, Japanese, 日本癌治療学会, 横浜, Domestic conference
    Oral presentation

  • 聴器扁平上皮癌に対する治療経験
    Yoshida Kenji, 中林 美日, Sasaki Ryohei, 西村 英輝, 河辺 哲也, 岡本 欣晃, Miyawaki Daisuke, 上園 玄, Ishihara Takeaki, Hasegawa Shingo, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    第47回日本癌治療学会学術大会, Oct. 2009, Japanese, 日本癌治療学会, 横浜, Domestic conference
    Oral presentation

  • リンパ節転移制御能からみたT3/T4下部直腸癌に対する術前化学放射線療法の検討
    神垣 隆, 高瀬 至郎, Nakamura Tetsu, Sumi Yasuo, Yamashita Kimihiro, 西村 英輝, Sasaki Ryohei, Imanishi Tatsuya, Suzuki Satoshi, 黒田 大介, Yokozaki Hiroshi, Sugimura Kazuro, Ku Yonson
    第47回日本癌治療学会学術大会, Oct. 2009, Japanese, 日本癌治療学会, 横浜, Domestic conference
    Oral presentation

  • HPV-DNA検出による中咽頭癌の科学放射線療法感受性予測
    太田 陽介, 鍬塚 葉子, 原田 文, 藤井 收, 辻野 佳世子, 副島 俊典, Sasaki Ryohei
    第293回日本医学放射線学会関西地方会, Oct. 2009, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • HPV-DNA検出による中咽頭癌の化学放射線療法感受性予測
    太田 陽介, 鍬塚 葉子, 原田 文, 藤井 收, 辻野 佳世子, 副島 俊典, Komatsu Hirokazu, 平山 裕次, 岩江 信法, 大林 千穂, 須藤 保, Sasaki Ryohei
    第47回日本癌治療学会学術大会, Oct. 2009, Japanese, 日本癌治療学会, 横浜, Domestic conference
    Oral presentation

  • 6大学連携オンコロジーチーム養成プランでのがん専門薬剤師養成コースの活動と現状
    西田 升三, Hirai Midori, 門林 宗男, 福岡 正博, 中川 和彦, 西村 恭昌, 平川 弘聖, 日野 雅之, 工藤 新三, 仲田 文造, 細野 雅子, 松井 徳造, 田中 京子, 高辻 功一, Nibu Ken-ichi, Sasaki Ryohei, Nishimura Yoshihiro, Minami Hironobu, 中野 孝司, 廣田 省三, 長谷川 誠紀, 村川 和重, 一瀬 理加, 鈴木 志津枝, 安藤 悦子
    第47回日本癌治療学会学術大会, Oct. 2009, Japanese, 日本癌治療学会, 横浜, Domestic conference
    Oral presentation

  • Treatment Outcomes of Squamous Cell Carcinoma of External Auditory Canal and Middle Ear
    Yoshida Kohsuke, Sasaki Ryohei, M. Nakabayashi, H. Nishimura, Y. Okamoto, Kawabe T, Hasegawa Shingo, N. Otsuki, Nibu Ken-ichi, Sugimura Kazuro
    15th ECCO, Sep. 2009, English, ベルリン, ドイツ, International conference
    Oral presentation

  • Particle Therapy for Mucosal Malignant Melanoma of the Head and Neck: A retrospective Study
    Miyawaki Daisuke, M. Murakami, Y. Demizu, M. Mima, K. Terashima, T. Arimura, Y. Niwa, Sasaki Ryohei, Sugimura Kazuro, Y. Hishikawa
    15th ECCO, Sep. 2009, English, ベルリン, ドイツ, International conference
    Oral presentation

  • 頭頚部原発髄外性形質細胞腫の多施設アンケート調査結果 第2報
    Sasaki Ryohei
    第1回 班会議 科学研究費補助金：山田班 「荷電粒子線を用いたがん治療の標準化と効率化に関する研究」, Aug. 2009, Japanese, 東北大学, 北海道, Domestic conference
    Oral presentation

  • 胸部食道癌における不均質補正の有無による線量の相違
    中山 雅央, Sasaki Ryohei, 西村 英輝, 河邊 哲也, Yoshida Kenji, Miyawaki Daisuke, 上園 玄, Ishihara Takeaki, 上原 和之, 岡本 欣明, 南 利明, 岡山 隆宣, Sugimura Kazuro
    第34回神戸放射線腫瘍懇話会, Aug. 2009, Japanese, 神戸, Domestic conference
    Oral presentation

  • 拡散テンソルを用いた脳腫瘍放射線治療計画の検討
    上原 和之, Sasaki Ryohei, 河邊 哲也, 西村 英輝, Yoshida Kenji, Miyawaki Daisuke, 上園 玄, Ishihara Takeaki, 中山 雅史, 青山 信和, 南 利明, 岡山 貴宣, Sugimura Kazuro
    第34回神戸放射線腫瘍懇話会, Aug. 2009, Japanese, 神戸, Domestic conference
    Oral presentation

  • 門脈腫瘍栓（Vp3、Vp4）かつ多発肝内転移を伴う肝細胞癌に対する動注科学療法同時併用粒子線治療の初期経験
    寺島 千貴, 村上 昌雄, 美馬 正幸, 有村 健, 丹羽 康江, 出水 祐介, 菱川 良夫, Miyawaki Daisuke, Sasaki Ryohei
    第292回日本医学放射線学会関西地方会, Jul. 2009, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • 頭頚部癌に対する集学的治療の取り組み中での放射線生物学の役割
    Sasaki Ryohei, 西村 英輝, Yoshida Kenji, 河邊 哲也, Miyawaki Daisuke, Sugimura Kazuro, Kiyota Naomi, Okuno Tatsuya, Minamikawa Tsutomu, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第48回日本医学放射線学会生物部会学術大会, Jul. 2009, Japanese, 日本医学放射線学会生物部会, 富山, Domestic conference
    Oral presentation

  • 限局型小細胞肺癌に対する科学放射線療法の治療成績
    Uezono Haruka, 西村 英輝, Sasaki Ryohei, 河邊 哲也, Yoshida Kenji, Miyawaki Daisuke, Ishihara Takeaki, Sugimura Kazuro
    第292回日本医学放射線学会関西地方会, Jul. 2009, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • 鼻副鼻腔未分化癌10症例の粒子線治療成績
    Morimoto Koichi, 村上 昌雄, 出水 祐介, Miyawaki Daisuke, 寺嶋 千貴, 有村 健, 丹羽 康江, Sasaki Ryohei, 菱川 良夫, Nibu Ken-ichi
    第33回日本頭頚部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 札幌, Domestic conference
    Oral presentation

  • 当院における下咽頭癌放射線治療の遡及的検討
    西村英輝, Sasaki Ryohei, 岡本欣晃, Yoshida Kenji, 河辺哲也, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki, 副島俊典, Sugimura Kazuro
    第33回日本頭頚部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 札幌, Domestic conference
    Oral presentation

  • 転移性骨腫瘍に対する粒子線治療成績
    美馬 正幸, 出水 祐介, 村上 昌雄, 有村 健, 寺嶋 千貴, 丹羽 康江, 菱川 良夫, Miyawaki Daisuke, Sasaki Ryohei
    第121回関西骨軟部腫瘍研究会(臨床), Jun. 2009, Japanese, 大阪, Domestic conference
    Oral presentation

  • 聴器扁平上皮癌に対する治療経験
    Yoshida Kenji, 中林 美日, Sasaki Ryohei, 岡本 欣晃, 西村 英輝, 河邊 哲也, Hasegawa Shingo, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    第33回日本頭頚部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 札幌, Domestic conference
    Oral presentation

  • 中咽頭癌に対する放射線治療の遡及的検討
    河邊 哲也, Sasaki Ryohei, 岡本 欣晃, Yoshida Kenji, 西村 英輝, 中川 貴博, Doi Kiyoshi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第33回日本頭頚部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 札幌, Domestic conference
    Oral presentation

  • 上咽頭癌に対する放射線化学療法の遡及的検討
    Sasaki Ryohei, 河邊 哲也, 西村 英輝, Yoshida Kenji, 岡本 欣晃, Hasegawa Shingo, Saito Miki, Ohtsuki Naoki, 福島 俊典, Nibu Ken-ichi
    第33回日本頭頚部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 札幌, Domestic conference
    Oral presentation

  • 口腔悪性腫瘍に対する粒子線治療成績
    出水 祐介, 村上 昌雄, 美馬 正幸, 寺嶋 千貴, 有村 健, 丹羽 康江, Morimoto Koichi, Miyawaki Daisuke, Sasaki Ryohei, 菱川 良夫
    第33回日本頭頚部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 札幌, Domestic conference
    Oral presentation

  • ハイリスクHPV由来の中咽頭癌は(日本人においても)集学的治療による治癒率が高いのか?
    太田 陽介, 鍬塚 葉子, 森木 健生, 原田 文, 藤井 收, 辻野 佳世子, 福島 俊典, Komatsu Hirokazu, 平山 裕次, 岩江 信法, 大林 千穂, 須藤 保, Sasaki Ryohei
    第33回日本頭頚部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 札幌, Domestic conference
    Oral presentation

  • 膵癌細胞を用いた化学放射線照射による細胞死のautophagy寄与に関する基礎的検討
    椋棒 英世, 辻村 敏明, Sasaki Ryohei, 寺井 祥雄, Toyama Hirochika, Shinzeki Makoto, Matsumoto Ippei, Ajiki Tetsuo, Ku Yonson
    第109回日本外科学会定期学術集会, Apr. 2009, Japanese, 日本外科学会, 福岡, Domestic conference
    Oral presentation

  • 放射線肺線維症内部の照射野内再発の診断におけるFDG-PETの有用性の検討
    Sasaki Ryohei, 中山 雅央, 岡本 欣晃, 西村 英輝, 河邊 哲也, Yoshida Kenji, 上原 和之, Sugimura Kazuro
    第68回日本医学放射線学会総会, Apr. 2009, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Oral presentation

  • 当院に於ける中咽頭癌の放射線治療成績
    河邊 哲也, Sasaki Ryohei, Yoshida Kenji, 西村 英輝, 岡本 欣晃, 上原 和之, 中山 雅央, Sugimura Kazuro, Ohtsuki Naoki, Nibu Ken-ichi
    第68回日本医学放射線学会総会, Apr. 2009, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Oral presentation

  • 当院における悪性神経膠腫の治療成績の遡及的検討
    西村 英輝, 上原 和之, Sasaki Ryohei, 岡本 欣晃, 河邊 哲也, Yoshida Kenji, 中山 雅央, Sasayama Takashi, 西原 賢在, Sugimura Kazuro
    第68回日本医学放射線学会総会, Apr. 2009, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Oral presentation

  • 転移性肝腫瘍に対する粒子線治療
    寺嶋 千貴, 村上 昌雄, Miyawaki Daisuke, 有村 健, 出水 祐介, 丹羽 康江, 菱川 良夫, Sasaki Ryohei, Sugimura Kazuro
    第68回日本医学放射線学会総会, Apr. 2009, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Oral presentation

  • 橋gliomaに対する放射線治療経験
    Yoshida Kenji, 芝 奈津子, Sasaki Ryohei, 西村 英輝, 河邊 哲也, 上原 和之, 中山 雅央, 岡本 欣晃, Sugimura Kazuro
    第68回日本医学放射線学会総会, Apr. 2009, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Oral presentation

  • Possible involvement of autophagy induced by chemoradiotherapy for pancreatic cancer.
    Tsujimura Toshiaki, Sasaki Ryohei, Hori Yuichi, Ku Yonson
    The International Pacreatic Research Forum 2009, Mar. 2009, English, The International Pacreatic Research Forum, 東京, International conference
    Poster presentation

  • 仙骨脊索腫に対する粒子線治療経験
    Miyawaki Daisuke, Sasaki Ryohei
    JROG, Nov. 2008, Japanese, 関西若手放射線治療勉強会, 大阪, Domestic conference
    Oral presentation

  • 橋 gliomaに対する放射線治療の経験
    Yoshida Kenji, Sasaki Ryohei, Nishimura Hideki, Kawabe Tetsuya, Okamoto Yoshiaki, Sugimura Kazuro
    第290回日本医学放射線学会 関西地方会, Nov. 2008, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • 膵癌細胞を用いたGemcitabine、放射線照射とその併用による細胞死のautophagy寄与に関する基礎的検討
    Tsujimura Toshiaki, Sasaki Ryohei, Toyama Hirochika, Shinzeki Makoto, Matsumoto Ippei, Ku Yonson
    第46回日本癌治療学会総会, Oct. 2008, Japanese, 日本癌治療学会, 名古屋, Domestic conference
    Oral presentation

  • 頭頸部悪性黒色腫に対する粒子線治療
    Miyawaki Daisuke, Sasaki Ryohei, Sugimura Kazuro
    日本放射線腫瘍学会第21回学術大会, Oct. 2008, Japanese, 日本放射線腫瘍学会, 札幌, Domestic conference
    Oral presentation

  • 頭頚部領域の髄外性形質細胞腫６例の放射線治療成績の検討
    Kawabe Tetsuya, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Yoshida Kenji, Soejima Toshinori, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    日本放射線腫瘍学会第21回学術大会, Oct. 2008, Japanese, 日本放射線腫瘍学会, 札幌, Domestic conference
    Oral presentation

  • 当院に於ける上咽頭癌に対する治療方針の変遷
    Sasaki Ryohei, Okamoto Yoshiaki, Kawabe Tetsuya, Nishimura Hideki, Yoshida Kenji, Soejima Toshinori, Hasegawa Shingo, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    第46回日本癌治療学会総会学術集会, Oct. 2008, Japanese, 日本癌治療学会, 名古屋, Domestic conference
    Oral presentation

  • 当院に於ける上咽頭癌に対する治療方針の変遷
    Sasaki Ryohei, Okamoto Yoshiaki, Kawabe Tetsuya, Nishimura Hideki, Yoshida Kenji, Soejima Toshinori, Hasegawa Shingo, Ohtsuki Naoki, Nibu Ken-ichi
    日本放射線腫瘍学会第21回学術大会, Oct. 2008, Japanese, 日本放射線腫瘍学会, 札幌, Domestic conference
    Oral presentation

  • 当院における食道癌に対する根治的放射線治療の遡及的検討
    Nishimura Hideki, Sasaki Ryohei, Okamoto Yoshiaki, Yoshida Kenji, Kawabe Tetsuya, Tamura Takao, Okuno Tatsuya, Soejima Toshinori, Sugimura Kazuro
    日本放射線腫瘍学会第21回学術大会, Oct. 2008, Japanese, 日本放射線腫瘍学会, 札幌, Domestic conference
    Oral presentation

  • 早期喉頭癌の局所制御におけるNF-κB発現の検討：他の生物学的マーカーとの比較
    Yoshida Kenji, Sasaki Ryohei, Nishimura Hideki, Okamoto Yoshiaki, Kawabe Tetsuya, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Soejima Toshinori, Sugimura Kazuro
    日本放射線腫瘍学会第21回学術大会, Oct. 2008, Japanese, 日本放射線腫瘍学会, 札幌, Domestic conference
    Oral presentation

  • 早期喉頭癌(T1-T2N0M0)の局所制御におけるNF-κB発現の検討 他の生物学的マーカーとの比較
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Saito Miki, Ohtsuki Naoki, Soejima Toshinori, Nibu Ken-ichi, Sugimura Kazuro
    第46回日本癌治療学会総会学術集会, Oct. 2008, Japanese, 日本癌治療学会, 名古屋, Domestic conference
    Oral presentation

  • 骨軟部肉腫に対する粒子線治療成績
    Miyawaki Daisuke, Sasaki Ryohei
    日本放射線腫瘍学会第21回学術大会, Oct. 2008, Japanese, 日本放射線腫瘍学会, 札幌, Domestic conference
    Oral presentation

  • 上咽頭癌に対する科学放射線治療の治療成績
    Kawabe Tetsuya, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Yoshida Kenji, Sugimura Kazuro
    神戸放射線腫瘍懇話会, Sep. 2008, Japanese, 神戸放射線腫瘍懇話会, 神戸, Domestic conference
    Oral presentation

  • 放射線抵抗性の規定因子：NF－Kappa Bの関与とその克服
    Sasaki Ryohei, Yoshida Kenji, Nishimura Hideki, Okamoto Yoshiaki, Soejima Toshinori, Saito Miki, Ohtsuki Naoki, Hayashi Yoshitake, Nibu Ken-ichi, Sugimura Kazuro
    第38回放射線による制癌シンポジウム, Jun. 2008, Japanese, 日本医学放射線学会生物部会, 高知, Domestic conference
    Oral presentation

  • 頭頚部領域の髄外性形質細胞腫の放射線治療の検討
    Sasaki Ryohei, Kawabe Tetsuya, Okamoto Yoshiaki, Nishimura Hideki, Yoshida Kenji, Sugimura Kazuro, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第289回日本医学放射線学会関西地方会, Jun. 2008, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • 当科における上咽頭癌の治療成績
    Hasegawa Shingo, Okamoto Yoshiaki, Sasaki Ryohei, Nishimura Hideki, Yoshida Kenji, Hirayama Yuji, Nibu Ken-ichi
    第32回日本頭頸部癌学会総会, Jun. 2008, Japanese, 日本頭頸部癌学会, 東京, Domestic conference
    Oral presentation

  • 当院における頭頚部原発形質細胞腫の放射線治療経験
    Kawabe Tetsuya, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Yoshida Kenji, Sugimura Kazuro
    JROG, Jun. 2008, Japanese, 関西若手放射線治療勉強会, 京都, Domestic conference
    Oral presentation

  • 転移性肝腫瘍に対する粒子線治療
    Miyawaki Daisuke, Sasaki Ryohei
    第289回日本医学放射線学会関西地方会, Jun. 2008, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • 肝細胞癌手術困難例に対する粒子線治療の意義
    Fukumoto Takumi, Tominaga Masahiro, Iwasaki Takeshi, Ajiki Tetsuo, Kusunoki Nobuya, Kito Masahiro, Takahashi Masanori, Sasaki Ryohei, Ku Yonson
    第108回日本外科学会, May 2008, Japanese, 日本外科学会, 長崎, Domestic conference
    Oral presentation

  • 頭頸部腺様嚢胞癌に対する粒子線治療：後ろ向き検討
    Miyawaki Daisuke, Morimoto Koichi, Sasaki Ryohei
    第67回日本医学放射線学会総会, Apr. 2008, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Oral presentation

  • T1/T2喉頭癌の局所制御におけるNF-kappa B活性の影響について
    Yoshida Kenji, Sasaki Ryohei, Nishimura Hideki, Okamoto Yoshiaki, Sugimura Kazuro, Nibu Ken-ichi
    第67回日本医学放射線学会総会, Apr. 2008, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Oral presentation

  • Impact of Nuclear Factor Kappa B Activity For Local Tumor Controllability by Radiotherapy in patients with T1/T2N0 laryngeal cancer
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    日本医学放射線学会関西地方会, Feb. 2008, English, 日本医学放射線学会, 大阪市, Domestic conference
    Oral presentation

  • Impact of Nuclear Factor Kappa B Activity for Local Tumor Controllability by Radiotherapy in Patients With T1/T2N0 Laryngeal Cancer
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Sugimura Kazuro, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第288回日本医学放射線学会関西地方会, Feb. 2008, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • 前立腺に対する高線量率組織内照射前後のHealth-related Quality of Life の変化
    Yoshida Kenji, Okamoto Yoshiaki, Sasaki Ryohei, Nishimura Hideki
    第20回日本放射線腫瘍学会, Dec. 2007, Japanese, 日本放射線腫瘍学会, 福岡, Domestic conference
    Oral presentation

  • 視神経近傍頭頚部腫瘍に対する粒子線治療後の視力障害症例の検討
    Miyawaki Daisuke, Nishimura Hideki, Sasaki Ryohei
    第20回日本放射線腫瘍学会, Dec. 2007, Japanese, 日本放射線腫瘍学会, 福岡, Domestic conference
    Oral presentation

  • 局所進行頭頚部がんに対する同時ブースとを用いた加速照射法の検討
    Nishimura Hideki, Sasaki Ryohei, Okamoto Yoshiaki, Yoshida Kenji, Soejima Toshinori, Sugimura Kazuro
    第20回日本放射線腫瘍学会, Dec. 2007, Japanese, 日本放射線腫瘍学会, 福岡, Domestic conference
    Oral presentation

  • T1/T2喉頭癌の局所制御におけるぬNuclear Factor Kappa B活性の影響についての検討
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    第20回日本放射線腫瘍学会, Dec. 2007, Japanese, 日本放射線腫瘍学会, 福岡, Domestic conference
    Oral presentation

  • Impact of Nuclear Factor Kappa B Activity For Local Tumor Controllability by Radiotherapy in patients with T1/T2N0 laryngeal cancer
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    第20回日本放射線腫瘍学会, Dec. 2007, English, 日本放射線腫瘍学会, 福岡市, Domestic conference
    Poster presentation

  • Confirmation of Proton Beam by Positron Emission Tomography (PET) Apparatus in Patients With Prostate Cancer
    Sasaki Ryohei, Miyawaki Daisuke, Nishimura Hideki, Sugimura Kazuro
    第20回日本放射線腫瘍学会, Dec. 2007, Japanese, 日本放射線腫瘍学会, 福岡, Domestic conference
    Oral presentation

  • 転移性腫瘍に対する少分割粒子線治療の試み
    Miyawaki Daisuke, Sasaki Ryohei
    第287回日本医学放射線学会関西地方会, Nov. 2007, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • 転移性骨腫瘍に対する粒子線治療の初期経験
    Miyawaki Daisuke, Sasaki Ryohei
    第287回日本医学放射線学会関西地方会, Nov. 2007, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • 術前CRTにて腫瘍縮小を得て、ISR施行した直腸癌の一例
    Takase Shiro, Imanishi Tatsuya, Nakamura Tetsu, Iwatani Yoshiteru, Suzuki Satoshi, Kim Yongsik, Kamigaki Takashi, Kuroda Daisuke, Kuroda Yoshikazu, Okamoto Yoshiaki, Sasaki Ryohei, Yoshida Kenji, Ohbayashi Chiho
    第69回日本臨床外科学会総会, Nov. 2007, Japanese, 日本臨床外科学会, 横浜, Domestic conference
    Oral presentation

  • 肝細胞癌に対する粒子線治療成績の検討
    Fukumoto Takumi, Tominaga Masahiro, Iwasaki Takeshi, Kusunoki Nobuya, Kito Masahiro, Takahashi Masanori, Sasaki Ryohei, Ku Yonson
    第69回日本臨床外科学会総会, Nov. 2007, Japanese, 日本臨床外科学会, 横浜, Domestic conference
    Oral presentation

  • 下咽頭癌T1、T2症例の治療成績
    Ohtsuki Naoki, Saito Miki, Sasaki Ryohei, Okamoto Yoshiaki, Nibu Ken-ichi
    第45回日本癌治療学会総会, Oct. 2007, Japanese, 日本癌治療学会, 京都, Domestic conference
    Oral presentation

  • Subacute Central Nervous System Morbidity after Proton Therapy and Carbon Ion Therapy Against Head and Neck Cancers and Skull Base Tumors: Impact of Sequential Evaluation by MR Imagings
    Miyawaki Daisuke, Sasaki Ryohei, Nishimura Hideki, Sugimura Kazuro
    The49thASTRO(AmericanScocietyofTherapeuticradiationOncology), Oct. 2007, English, ASTRO (American Scociety of Therapeutic radiation Oncology), Los Angeles, USA, International conference
    Oral presentation

  • Radiation Therapy for Early Hypopharyngeal Cancer
    Nishimura Hideki, Sasaki Ryohei, Okamoto Yoshiaki, Yoshida Kenji, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki, Soejima Toshinori, Sugimura Kazuro
    ASTRO49, Oct. 2007, English, ASTRO, Los Angeles, USA, International conference
    Poster presentation

  • Radiation Therapy for Early Hypopharyngeal Cancer
    Nishimura Hideki, Sasaki Ryohei, Okamoto Yoshiaki, Yoshida Kenji, Saito Miki, Soejima Toshinori, Sugimura Kazuro
    The49thASTRO(AmericanScocietyofTherapeuticradiationOncology), Oct. 2007, English, ASTRO (American Scociety of Therapeutic radiation Oncology), Los Angeles, USA, International conference
    Oral presentation

  • Proton Therapy and Carbon Ion Therapy for Patients With Hepatocellular Carcinoma: The Hyogo Ion Beam Medical Center Experience
    Miyawaki Daisuke, Nishimura Hideki, Sasaki Ryohei
    The49thASTRO(AmericanScocietyofTherapeuticradiationOncology), Oct. 2007, English, ASTRO (American Scociety of Therapeutic radiation Oncology), Los Angeles, USA, International conference
    Oral presentation

  • Intraoperative Radiotherapy for the Abdominal Lymph Nodes in Patients With Esophageal Carcinoma
    Sasaki Ryohei, Yoshida Kenji, Nishimura Hideki, Okamoto Yoshiaki, Sugimura Kazuro
    The49thASTRO(AmericanScocietyofTherapeuticradiationOncology), Oct. 2007, English, ASTRO (American Scociety of Therapeutic radiation Oncology), Los Angeles, USA, International conference
    Oral presentation

  • Impact of Selective Mitochondrial DNA Polymerase Gamma Inhibition by Vitamin K Compounds Against Human Cancer Cells and Radioresistant Clones
    Sasaki Ryohei, Suzuki Yasuyuki, Yoshida Kohsuke, Nishimura Hideki, Okamoto Yoshiaki, Sugimura Kazuro
    ASTRO49, Oct. 2007, English, ASTRO, Los Angeles, USA, International conference
    Poster presentation

  • Impact of Selective Mitochondrial DNA Polymerase Gamma Inhibition by Vitamin K Compounds Against Human Cancer Cells and Radioresistant Clones
    Sasaki Ryohei, Yoshida Kenji, Nishimura Hideki, Okamoto Yoshiaki, Sugimura Kazuro
    The49thASTRO(AmericanScocietyofTherapeuticradiationOncology), Oct. 2007, English, ASTRO (American Scociety of Therapeutic radiation Oncology), Los Angeles, USA, International conference
    Oral presentation

  • Impact of Nuclear Factor Kappa B Activity For Local Tumor Controllability by Radiotherapy in patients with T1/T2N0 laryngeal cancer
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    ASTRO49, Oct. 2007, English, ASTRO, Los Angeles, USA, International conference
    Poster presentation

  • Impact of Nuclear Factor Kappa B Activity for Local Tumor Controllability by Radiotherapy in Patients With T1/T2N0 Laryngeal Cancer
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Sugimura Kazuro
    The49thASTRO(AmericanScocietyofTherapeuticradiationOncology), Oct. 2007, English, ASTRO (American Scociety of Therapeutic radiation Oncology), Los Angeles, USA, International conference
    Oral presentation

  • Feasibility of FLT-PET for monitoring the radiation therapy in head and neck cancers and lung cancers: Preliminary study in comparison with FDG-PET
    Sakamoto Setsu, Sasaki Ryohei
    AnnualCongressofEuropeanAssociationofNuclearMedicine(EANM'07), Oct. 2007, English, 欧州核医学会, コペンハーゲン, デンマーク, International conference
    Others

  • Confirmation of Proton Beam by Positron Emission Tomography (PET) Apparatus in Patients With Prostate Cancer
    Sasaki Ryohei, Miyawaki Daisuke, Nishimura Hideki, Sugimura Kazuro
    The49thASTRO(AmericanScocietyofTherapeuticradiationOncology), Oct. 2007, English, ASTRO (American Scociety of Therapeutic radiation Oncology), Los Angeles, USA, International conference
    Oral presentation

  • Subacute Radiation Injury following Proton therapy and Carbon Ion Therapy against Head and Neck Cancers and Skull Base Tumors
    Miyawaki Daisuke, Nishimura Hideki, Sasaki Ryohei, Sugimura Kazuro
    The5thJUCTS(Japan-USCancerTherapySymposium), Sep. 2007, English, JUCTS (Japan-US Cancer Therapy Symposium), 仙台, International conference
    Oral presentation

  • Subacute Central Nervus System Morbidity after Proton therapy and Carbon Ion Therapy against Head and Neck Cancers and Skull Base Tumors: Impact of Sequential Evaluation by MR Imagings
    Miyawaki Daisuke, Sasaki Ryohei, Nishimura Hideki, Sugimura Kazuro
    The14thECCO(EupopeanCancerConference), Sep. 2007, English, ECCO (Eupopean Cancer Conference), Barcelona, Spain, International conference
    Oral presentation

  • Proton radiotherapy for patients with prostate cancer - in the Hyogo Ion Beam Medical Center (HIBMC) experience
    Miyawaki Daisuke, Nishimura Hideki, Sasaki Ryohei
    The14thECCO(EupopeanCancerConference), Sep. 2007, English, ECCO (Eupopean Cancer Conference), Barcelona, Spain, International conference
    Oral presentation

  • Particle Therapy Against HCC Clinical Results of 103 cases
    Miyawaki Daisuke, Nishimura Hideki, Sasaki Ryohei, Fukumoto Takumi, Ku Yonson
    The5thJUCTS(Japan-USCancerTherapySymposium), Sep. 2007, English, JUCTS (Japan-US Cancer Therapy Symposium), 仙台, International conference
    Oral presentation

  • Ion-beam treatment in Hyogo Ion Beam Medical Center (HIBMC)
    Miyawaki Daisuke, Sasaki Ryohei
    The5thJUCTS(Japan-USCancerTherapySymposium), Sep. 2007, English, JUCTS (Japan-US Cancer Therapy Symposium), 仙台, International conference
    [Invited]
    Invited oral presentation

  • Impact of Selective Mitochondrial DNA Polymerase Gamma Inhibition by Vitamin K Compounds Against Human Cancer Cells and Radioresistant Clones
    Sasaki Ryohei, Suzuki Yasuyuki, Yoshida Kohsuke, Nishimura Hideki, Okamoto Yoshiaki, Sugimura Kazuro
    ECCO14, Sep. 2007, English, ECCO, Barcelona, Spain, International conference
    Poster presentation

  • Impact of Selective Mitochondrial DNA polymerase Gamma Inhibition by Vitamin K Compounds against Human Cancer
    Sasaki Ryohei, Yoshida Kenji, Nishimura Hideki, Okamoto Yoshiaki, Sugimura Kazuro
    The14thECCO(EupopeanCancerConference), Sep. 2007, English, ECCO (Eupopean Cancer Conference), Barcelona, Spain, International conference
    Oral presentation

  • Impact of Nuclear Factor Kappa B Activity For Local Tumor Controllability by Radiotherapy in patients with T1/T2N0 laryngeal cancer
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    ECCO14, Sep. 2007, English, ECCO, Barcelona, Spain, International conference
    Poster presentation

  • Impact of Nuclear factor kappa B activity for local tumor controllability by radiotherapy in patients with T1/T2 laryngeal cancer
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Sugimura Kazuro
    The14thECCO(EupopeanCancerConference), Sep. 2007, English, ECCO (Eupopean Cancer Conference), Barcelona, Spain, International conference
    Oral presentation

  • Health-related Quality of Life in Patients with Localized Prostate Cancer Received High-Dose-Rate Brachytherapy: A Time-Course Analysis
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Sugimura Kazuro
    5thJapan-USCancerTherapySymposium, Sep. 2007, English, Japan-US Cancer Therapy Symposium, 仙台, International conference
    Poster presentation

  • Health-related Quality of Life in Patients with Localized Prostate Cancer Received High-Dose-Rate Brachytherapy: A Time-Course Analysis
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Sugimura Kazuro
    ECCO14, Sep. 2007, English, ECCO, Barcelona, Spain, International conference
    Poster presentation

  • Health-Related Quality of Life (HRQOL) in patients swith localized prostate cancer received High-dose-rate brachytherapy (HDR-BT)
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Sugimura Kazuro
    The5thJUCTS(Japan-USCancerTherapySymposium), Sep. 2007, English, JUCTS (Japan-US Cancer Therapy Symposium), 仙台, International conference
    Oral presentation

  • Efficacy od intraoperative radiotherapy for the upper abdominal lymph nodes system in patients with esophageal carcinoma
    Sasaki Ryohei, Yoshida Kohsuke, Okamoto Yoshiaki, Nishimura Hideki, Sugimura Kazuro
    5thJapan-USCancerTherapySymposium, Sep. 2007, English, Japan-US Cancer Therapy Symposium, 仙台, International conference
    Poster presentation

  • Efficacy od intraoperative radiotherapy for the upper abdominal lymph nodes system in patients with esophageal carcinoma
    Sasaki Ryohei, Yoshida Kohsuke, Okamoto Yoshiaki, Nishimura Hideki, Sugimura Kazuro
    The5thJUCTS(Japan-USCancerTherapySymposium), Sep. 2007, English, JUCTS (Japan-US Cancer Therapy Symposium), 仙台, International conference
    Oral presentation

  • Confirmation of proton beam by positron emission tomography apparatus in patients with prostate cancer
    Sasaki Ryohei, Miyawaki Daisuke, Nishimura Hideki, Sugimura Kazuro
    The14thECCO(EupopeanCancerConference), Sep. 2007, English, ECCO (Eupopean Cancer Conference), Barcelona, Spain, International conference
    Oral presentation

  • Autoactibvation of proton beam confirmed with positron emission tomography in patients with prostate cancer
    Sasaki Ryohei, Nishimura Hideki, Sugimura Kazuro, Miyawaki Daisuke
    The5thJUCTS(Japan-USCancerTherapySymposium), Sep. 2007, English, JUCTS (Japan-US Cancer Therapy Symposium), 仙台, International conference
    [Invited]
    Invited oral presentation

  • Analysis of cases with visual impairment caused by particle therapy for head-and neck tumors adjacent to optic nerve
    Miyawaki Daisuke, Nishimura Hideki, Sasaki Ryohei
    The5thJUCTS(Japan-USCancerTherapySymposium), Sep. 2007, English, JUCTS (Japan-US Cancer Therapy Symposium), 仙台, International conference
    Oral presentation

  • 頭頸部癌進行例に対する根治手術後化学放射線療法の検討
    Ohtsuki Naoki, Saito Miki, Tanimoto Hitoshi, Hasegawa Shingo, Ijuin Takahiro, Doi Kiyoshi, Hirayama Yuji, Nibu Ken-ichi, Sasaki Ryohei, Okamoto Yoshiaki
    第31回日本頭頸部癌学会総会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • 頭頸部癌進行例に対する根治手術後化学放射線療法の検討
    Ohtsuki Naoki, Saito Miki, Tanimoto Hitoshi, Hasegawa Shingo, Ijuin Takahiro, Doi Kiyoshi, Hirayama Yuji, Nibu Ken-ichi, Sasaki Ryohei, Okamoto Yoshiaki
    第３１回日本頭頸部癌学会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • 当院におけるI－II期下咽頭癌に対する根治的放射線治療の遡及的検討
    Nishimura Hideki, Sasaki Ryohei, Okamoto Yoshiaki, Yoshida Kenji, Sugimura Kazuro, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki, Soejima Toshinori
    第３１回日本頭頸部癌学会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • 当院におけるI-II期下咽頭癌に対する根治的放射線治療の遡及的検討
    Nishimura Hideki, Sasaki Ryohei, Okamoto Yoshiaki, Yoshida Kenji, Sugimura Kazuro, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki, Soejima Toshinori
    第31回日本頭頸部癌学会総会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • １期／２期喉頭癌に対する根治的放射線治療成績
    Yoshida Kenji, Sasaki Ryohei, Nishimura Hideki, Okamoto Yoshiaki, Sugimura Kazuro, Nibu Ken-ichi
    第６６回日本医学放射線学会, Apr. 2007, Japanese, 日本放射線学会, 横浜, Domestic conference
    Oral presentation

  • I/II期喉頭癌に対する根治的放射線治療成績
    Yoshida Kenji, Sasaki Ryohei, Nishimura Hideki, Okamoto Yoshiaki, Soejima Toshinori, Nibu Ken-ichi, Sugimura Kazuro
    第66回日本医学放射線学会総会, Apr. 2007, Japanese, 日本医学放射線学会, 横浜市, Domestic conference
    Poster presentation

  • A Case report of cardiac leiomyozarcoma treated by surgical resection and chemo-radiation therapy
    Uotani Kensuke, Nishimura Hideki, Kotani Yoshikazu, Sasaki Ryohei, Fujii Masahiko
    AsianSocietyofCardiovascularImaging2007, Apr. 2007, English, ASCI, ソウル, 韓国, International conference
    Poster presentation

  • 1期/2期喉頭癌に対する根治的放射線治療成績
    Yoshida Kenji, Sasaki Ryohei, Nishimura Hideki, Okamoto Yoshiaki, Sugimura Kazuro, Nibu Ken-ichi
    第66回日本医学放射線学会総会, Apr. 2007, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Oral presentation

  • 転移性肺腫瘍に対する粒子線治療・放射線治療の初期経験
    SASAKI RYOHEI
    第11回関西転移性肺腫瘍研究会, Mar. 2007, Japanese, 関西転移性肺腫瘍研究会, 大阪, Domestic conference
    Oral presentation

  • 当院における肺定位放射線治療
    NISHIMURA HIDEKI, OKAMOTO YOSHIAKI, SASAKI RYOHEI, Sugimura Kazuro
    神戸放射線腫瘍懇話会, Feb. 2007, Japanese, 神戸放射線腫瘍懇話会, 神戸, Domestic conference
    Oral presentation

  • 上咽頭癌放射線化学療法中に発症した5-FU脳症の一例
    NISHIMURA HIDEKI, SASAKI RYOHEI, OKAMOTO YOSHIAKI, Sugimura Kazuro
    第285回 日本医学放射線学会 関西地方会, Feb. 2007, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • HCCに対する粒子線治療後Bilomaを形成した一例
    NISHIMURA HIDEKI, SASAKI RYOHEI
    第285回 日本医学放射線学会 関西地方会, Feb. 2007, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • 放射線治療が奏効した全身に多発する濾胞性樹状細胞肉腫の1例
    OKAMOTO YOSHIAKI, NISHIMURA HIDEKI, SASAKI RYOHEI, Sugimura Kazuro
    第19回日本放射線腫瘍学会, Nov. 2006, Japanese, 日本放射線腫瘍学会, 仙台, Domestic conference
    Oral presentation

  • 当院における下咽頭癌に対する根治的放射線治療の遡及的解析
    NISHIMURA HIDEKI, SASAKI RYOHEI, OKAMOTO YOSHIAKI, Sugimura Kazuro
    第19回日本放射線腫瘍学会, Nov. 2006, Japanese, 日本放射線腫瘍学会, 仙台, Domestic conference
    Oral presentation

  • 当院における下咽頭癌に対する根治的放射線治療の遡及的解析
    NISHIMURA HIDEKI, SASAKI RYOHEI, OKAMOTO YOSHIAKI, Sugimura Kazuro
    日本放射線腫瘍学会第19回学術大会, Nov. 2006, Japanese, 日本放射線腫瘍学会, 仙台, Domestic conference
    Poster presentation

  • 巨大肝癌に対して2回の陽子線治療で制御できた1例
    NISHIMURA HIDEKI, SASAKI RYOHEI, Sugimura Kazuro
    第284回 日本医学放射線学会 関西地方会, Nov. 2006, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • ペースメーカー及びICD装着患者の放射線療法の全国調査とガイドライン作成
    SASAKI RYOHEI
    第19回日本放射線腫瘍学会, Nov. 2006, Japanese, 日本放射線腫瘍学会, 仙台, Domestic conference
    Oral presentation

  • FDG-PET世代の肺がん・食道がんの放射線治療
    SASAKI RYOHEI
    第19回日本放射線腫瘍学会, Nov. 2006, Japanese, 日本放射線腫瘍学会, 仙台, Domestic conference
    [Invited]
    Invited oral presentation

  • Clinical Manifestations of Esophageal Squamous Cell Carcinoma with Hepatitis C Virus Infection Treated with Chemo-Radiotherapy
    SASAKI RYOHEI, OKAMOTO YOSHIAKI
    北米放射線学会（RSNA）, Nov. 2006, English, 北米放射線学会, シカゴ, International conference
    Poster presentation

  • 高精度・放射線治療の展開
    SASAKI RYOHEI
    第3回兵庫県がん研究会, Oct. 2006, Japanese, 兵庫県がん研究会, 神戸, Domestic conference
    Oral presentation

  • 炭素イオン線治療を行った 上顎骨骨肉腫の一例
    SASAKI RYOHEI
    神戸放射線腫瘍懇話会, Aug. 2006, Japanese, 神戸放射線腫瘍懇話会, 神戸, Domestic conference
    Oral presentation

  • 頭蓋底腫瘍に対する粒子線治療後の脳MRIの変化
    NISHIMURA HIDEKI, SASAKI RYOHEI, Sugimura Kazuro
    第3回日本粒子線治療臨床研究会, Jun. 2006, Japanese, 日本粒子線治療臨床研究会, 神戸, Domestic conference
    Oral presentation

  • 骨軟部腫瘍の治療成績
    SASAKI RYOHEI
    第106回関西骨軟部腫瘍研究会, Jun. 2006, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference
    Oral presentation

  • 神戸大学におけるNPO方式による遠隔画像診断について
    FUJII MASAHIKO, Taniguchi Takanori, OHNO YOSHIHARU, SASAKI RYOHEI, Sugimura Kazuro
    第65回日本医学放射線学会学術集会, Apr. 2006, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Poster presentation

  • 神戸大学におけるNPO方式による遠隔画像診断について
    FUJII MASAHIKO, Taniguchi Takanori, OHNO YOSHIHARU, SASAKI RYOHEI, Sugimura Kazuro
    第65回日本医学放射線学会総会, Apr. 2006, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Public symposium

■ Affiliated Academic Society
  • THE JAPANESE RADIATION RESEARCH SOCIETY

  • Japanese breast cancer society

  • 日本ミトコンドリア学会

  • Amecian Society of Therapeutic Radiation Oncology

  • 日本放射線腫瘍学会

  • 日本医学放射線学会

■ Research Themes
  • 局所進行直腸癌のナノ粒子を用いた術前放射線免疫療法のモデル構築とその応用
    松田 武, 青井 貴之, 佐々木 良平, 山下 公大, 山下 智也, 高村 史記
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2024 - 31 Mar. 2027

  • 難治性局所進行乳がんに対する金属ナノ粒子併用・超高線量率放射線治療法の開発
    椋本 成俊, 佐々木 良平, 宮脇 大輔, 清水 康之
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2023 - 31 Mar. 2026

  • 放射線応答エクソソームによる直腸癌Total neoadjuvant therapy（TNT）の治療効果予測
    佐々木 理栄, 佐々木 良平, 松田 武, 小林 加奈, 岩下 和真
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2023 - 31 Mar. 2026

  • 吸収性スペーサーを用いた体内空間可変・定位放射線治療の実用化研究
    佐々木 良平
    日本学術振興会, 科学研究費助成事業, 基盤研究(B), 神戸大学, 28 Feb. 2024 - 31 Mar. 2025

  • Development of radiosensitized nanoparticles for all cancers using simple and innovative surface-modified DDS
    赤坂 浩亮, 荻野 千秋, 佐々木 良平, 宮脇 大輔, 中山 雅央, 椋本 成俊, 清水 康之
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2022 - 31 Mar. 2025
    金属ナノ粒子を用いた放射線増感剤の研究には、腫瘍への送達性と生体安全性の課題が常に付きまとうが、我々のグループは先行研究において、メルボルン大学のFrank Caruso教授のグループが開発したAPS （Antibody Polyphenol System)と呼ばれる金属ナノ粒子を抗体でコーティングする技術を応用することで、前述の課題の解決に成功した。世界最大級のROS産生能を有する過酸化チタンナノ粒子と、抗体コーティング技術であるAPSの融合は、これまでに類を見ない革新的ながん治療の開発に繋がる。 本申請において、我々はAPS-過酸化チタンナノ粒子の臨床応用に向け、①多種の抗体に対応したAPSの合成、②各種がん腫瘍への特異的集積性の評価、③放射線増感効果の確認、④生体安全性の確認、の具体的な４課題を通し、First-in-Humanの臨床試験を見据えた非臨床試験の準備に取り組む。 当該年度においては、抗CD44抗体を修飾した過酸化チタンナノ粒子を用いて、MDA-MB-231細胞、BT-474細胞、及びMIAPaCa2細胞に対する特異的集積性、放射線併用時の抗腫瘍効果、及びライソソームへの取り込み確認の検討を実施した。、

  • Space-making radiotherapy using bioabsorbable spacer
    佐々木 良平, 福本 巧, 宮脇 大輔, 出水 祐介, 窪田 光, 岩下 和真, 赤坂 浩亮, 椋本 成俊
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2022 - 31 Mar. 2025
    申請者らは、ポリグルコール酸（PGA）縫合糸を3次元的に加工した「不織布型吸収性スペーサー」の独自開発を行い、これを用いた粒子線治療期間のみ腫瘍と正常組織を分離する「体内空間可変治療」を確立した。この方法は、我々の First-in-Human での臨床治験を経て薬事承認（2018年）と保険収載（2019年）に至っている。本研究では、本邦における粒子線治療の実績調査による本治療の現状把握と問題点の抽出を行いつつ、これをX線治療へと展開させ、切除不能膵臓がん等に対する体内空間可変・定位放射線治療のPhase I/II臨床試験を実施することである。本年度の実績は、神戸大学医学部附属病院において特定臨床研究「消化管近接局所進行切除不能および局所再発悪性腫瘍に対する吸収性スペーサ併用定位放射線療法のfeasibility study」を開始したことである。選択基準は、病理学的あるいは臨床的に悪性腫瘍と診断されている症例、強度変調放射線治療または定位放射線治療により、大線量の根治的な放射線治療の適応のある症例、腫瘍が１照射範囲に限局している症例、スペーサ留置が可能と判断され、プロトコルに沿った放射線治療が可能と判断される症例などであり、主要評価項目は腫瘍が１照射範囲に限局していること。副次評価項目は、有効性評価項目として線量分布、放射線治療完遂、安全性評価項目として、全プロトコル期間中にみられたすべての疾病等、ネスキープの不具合の有無とその内容である。プロトコル治療として吸収性スペーサ併用高精度放射線療法を吸収性スペーサ留置術、放射線治療：40-50Gy/5frを実施し、予定症例数は6例である。現在は症例集積中であり、同時に結果の解析を実行していく。圧縮性スペーサーに関しては試作品の動物実験を行っており、動物の腹腔内での厚みの保持など、一定の成果を得ている。

  • Comprehensive analysis of radiation-response miRNA for cell-to-cell communication
    小林 加奈, 佐々木 良平, 椋本 成俊, 清水 康之, 岩下 和真
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2021 - 31 Mar. 2024
    昨年度の目標は以下の3つであり、そのうち１と2は下記の学会報告、論文発表を行った。 1.ヒト膵がん細胞：MiyaPaca-2細胞を用いたNanosight を用いたエクソソームのサイズ分布、透過型電子顕微鏡（TEM）による形態観察2.ヒト膵がん細胞：MiyaPaca-2細胞を用いてエクソソームを標識し、蛍光顕微鏡で観察による隣接細胞への取込と、ROS産生、DNA障害の変化、放射線感受性評価する。3.ヒト大腸がん細胞株：HCT116は他の大腸がん細胞と比較して極めて肝転移の頻度が高いことが報告されているので、HT29、WiDr、HCT-15, HCC2998などとの比較の中で大腸がんの転移しやすさに関連するエクソソーム内のmiRNAのmiRNA Microarrayにて網羅的解析を実施する。【学会報告】① 同一腫瘍細胞間の放射線応答を制御するエクソソーム内マイクロRNAの網羅的解析、第58回日本放射線腫瘍学会生物部会学術大会2021年6月4日② エクソソーム内マイクロRNAを介した放射線応答制御に関する基礎的検討、第34回放射線腫瘍学会,2021年11月12日～2022年1月15日③放射線照射された腫瘍から放出されたエクソソームによる放射線増感効果, 2021年度 近畿がん診療推進ネットワーク「学術奨励賞選考会」,2022年3月4日 【論文発表】Ai Nakaoka, Kana Kobayashi, Mennaallah Hassan and Ryohei Sasaki, Exosomes in Cancer Diagnosis and Radiation Therapy, IntechOpen Book, 2021年12月21日掲載, Chapter: Extracellular Vesicles, DOI: 10.5772/intechopen.101684 行った。

  • Development of Helium Ion CT Image System for Particle Therapy
    王 天縁, 沖本 智昭, 佐々木 良平, 出水 祐介, 赤城 卓, 徳丸 直郎, 松尾 圭朗
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2021 - 31 Mar. 2024
    本申請はクリニカルクエスチョンに基づき、これまでに解決出来なかった粒子線治療計画時における粒子飛程不確かさ問題の解決に向け、治療室の中で取得可能となる粒子線に基づくイオンCT (Ion Computed Tomography; ICT) 画像システムの新規開発である。申請者らが目指しているヘリウム(Helium)という重い粒子のICTは、軽い陽子(Proton)より物質中の散乱が少なく、重い炭素重粒子(Carbon)より物質中の原子核破砕反応の発生率も少ないため、臨床応用に耐えうる高解像度CT画像の取得に使う粒子として、最も適切であると考えられる。 ヘリウムICT撮影系のシステム構築： 申請者らは兵庫県立粒子線医療センターのシンクロトロン加速器により生成される150 MeV/uエネルギーのヘリウム粒子を使う。このシステムは拡大照射法であり、コーンビームの投影データを一気に収集できる。これにより撮影時間を短縮することが出来る。粒子線の照射ポートが水平方向に固定されているため、ローテーションテーブルを用いて、数度ごとに投影データを取得する。本申請では空間分解能の高い投影データを取得するため、シンチレーションとCMOSカメラを組み合わせた暗箱を作成する。シンチレーションには線エネルギー移行量(LET)に対する直線性に優れているジンクセルファイド(ZnS)を使用する。これによって線量を低いところまで正確に測定し、且つ検出器の空間分解能を0.5mm2程度にまで向上させる。

  • A Novel immunoradiotherapy using TiOxNPs and tumor-derived exosome
    西村 英輝, 佐々木 良平, 赤坂 浩亮, 荻野 千秋, 小林 加奈
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2021 - 31 Mar. 2024
    これまでの研究で申請者らの研究グループは独自に合成した過酸化チタンナノ粒子がX線照射により活性酸素種（ROS）を生成し、細胞・動物実験で放射線増感効果が得られることを報告した。放射線増感効果をもつナノ粒子として、金、銀、ハフニウム等いくつかの無機ナノ粒子が広く研究されているが、これらのナノ粒子間で増感効果の優劣や性質の違いは評価されておらず、ナノ粒子の材質や粒子サイズ、生成されるROSの種類といった物理的性質の違いが実際の生物学的効果にどのように影響を及ぼすのか明らかになっていない。そこで本研究では、過酸化チタンナノ粒子と最も広く報告されている金ナノ粒子を比較し、それぞれのラジカル産生能、その分子機序、抗腫瘍効果を検討し、その成果がNanomaterial誌に掲載された。またIn vivoでの過酸化チタンナノ粒子の動態とその生物学的評価を実施してその成果がColloids Surf B Biointerfaces誌に掲載された。さらに安定した過酸化チタンナノ粒子の生成方法を確立し、ナノ粒子の表面修飾の方法を改良中である。しかしながら、最も重要なことを投与経路とその腫瘍への集積性を向上させることであり、そのためにはナノ粒子の生体内の動態を解明しなければならない。金属ナノ粒子が医学応用されるためには，その効果や利用価値（メリット）が、リスクや随伴する有害反応（デメリット）を大きく上回る場合に限定されるため、がんや肉腫等の生命に直結する悪性疾患や病態では、その治療効果や診断能が極めて重要でありが、特に放射線療法との併用ではメリットが大きい場面が多いため、臨床を目指した粒子の最適化をさらに進めていく予定である。

  • Novel radiosensitizer with inorganic nanoparticles and antibodies assembly
    佐々木 良平, 荻野 千秋, 赤坂 浩亮, 西村 勇哉, 中山 雅央
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)), Kobe University, 27 Oct. 2020 - 31 Mar. 2024
    我々のグループは放射線と併用することで大量の活性酸素（Reactive Oxygen Species: ROS）を産生し、放射線増感効果を著明に増加させる過酸化チタンナノ粒子の開発に成功し、世界的にも先駆的な立場で過酸化チタンナノ粒子を利用した放射線増感剤の開発に取り組んでいる。この素材を臨床応用するには、過酸化チタンナノ粒子が①腫瘍に特異的に集積し、②生体安全性を有する必要がある。これらを達成するためには、過酸化チタンナノ粒子の表面修飾技術が必要不可欠である。メルボルン大学のFrank Caruso教授のグループはPMAP（Polyphenol-Mediated Assembly of Proteins)と呼ばれる独自のナノ粒子コーティング技術を開発しており、PMAPを応用することで、過酸化チタンナノ粒子にDrug Delivery System（DDS）と体内毒性低減をもたらすことが可能であると期待できる。世界最大級のROS産生能を有する過酸化チタンナノ粒子とPMAPの融合は、これまでに類を見ない革新的ながん治療の開発に繋がることが大いに期待できる。我々は日本・オーストラリアを基軸としたナノ粒子放射線増感研究ネットワークを形成し、画期的な放射線増感剤の開発から臨床応用まで取り組む。本年度には、検討項目の一つとして、がん幹細胞に高発現しているCD44を認識するモノクロナール抗体と過酸化チタンナノ粒子を結合させるPMAPシステムをに応用することを手掛け、in vitroの実験系で確認した。その結果、CD44を高頻度に発現するがん細胞へのPMAP を介して高効率な過酸化チタンナノ粒子の輸送に成功した。

  • A novel immuno-radiotherapy using autologus T cell and pH-responsive capsule for delivery of inorganic nanoparticles
    佐々木 良平, 荻野 千秋, 赤坂 浩亮, 窪田 光
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Kobe University, 30 Jul. 2020 - 31 Mar. 2023
    本研究では、細胞傷害性T（CD8陽性）細胞由来のエクソソームを単離し、優れた放射線増感作用を有する過酸化チタンナノ粒子の運搬役として利用し、治療抵抗性固形悪性腫瘍に対する新たな免疫放射線療法を提案することである。今回の提案は異なる機能のT細胞同士の情報伝達が、IL-2等のサイトカインによる液性免疫だけでなく、それぞれが放出するエクソソームによる細胞間情報伝達でも制御されている事を見いだした事に端を発する。CD8細胞はその増幅が困難であり、その理由に制御性T細胞（Treg）の強力な抑制機構があると考えられる。今回の申請では、ナノ粒子と放射線照射による抗原刺激を介して、CD8細胞を著明に増加させる方法を立案した。 放射線治療は、その治療経過に伴い腫瘍細胞がPD-L1等の腫瘍抗原を発現が増強し、CD8細胞の膜表面上のPD-1と腫瘍細胞のPD-L1が免疫チェックポイントを形成し治療抵抗性の原因となる。大きな治療効果のためには、放射線増感剤を特異的に取り込ませ、治療効果比の高い免疫放射線療法を構築する事が有効である。腫瘍細胞の標的化に腫瘍細胞からの抗原提示を受けたCD8細胞由来のエクソソームを用い、放射線増感剤には独自開発した過酸化チタンナノ粒子を用いてそれらをEx vivoで融合させ、再投与後に放射線療法を実施し高い治療効果を得ることを検討している。 本年度の研究成果は、過酸化チタンナノ粒子が免疫放射線療法を著明に増感させ、これまでにない治療効果を得た。その分子機序は過酸化チタンナノ粒子がの活性酸素増幅効果に起因し、抗原提示を受けた樹状細胞によるCD8細胞の増幅など、二次リンパ組織における免疫系細胞の関与を明らかにしてきた。

  • Development of new radiation therapy using ultra-high dose rate slit beam and metal nanoparticles
    Mukumoto Naritoshi
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2020 - 31 Mar. 2023
    Synchrotron X-ray beams permit the delivery of very high radiation doses to tumors in short period of time with a single fraction using arrays of micro-slit beam radiation therapy. In this study, we have challenged to treat multiple metastatic lung tumors by applying MRT to mouse tumor-bearing right lung with comparing to the broad beam treatment from the same radiation source. Synchrotron X-ray beam radiation was performed using BL28B2 beam-line at the SPring-8 facility, Hyogo, Japan. The animals used were male DBA/2 mice aged 13-15 weeks old, inoculated KLN205 2.5 x 10^6 cells/mouse 4 weeks before the exposure of the beam. As for radiation techniques, anterior-posterior 12 x 30 mm windows were set, and either a conventional unidirectional broad beam or unidirectional array of MRT was used. Delivered dose of the broad beam was 36 Gy while that of the MRT were 36-120 Gy. The observation period was 27 days after the irradiation.

  • 金属ナノ粒子を応用した新規・免疫放射線増感療法の開発
    岡本 欣晃, 赤坂 浩亮, 佐々木 良平, 宮脇 大輔, 妹尾 悟史, 川口 弘毅, 窪田 光
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2020 - 31 Mar. 2023
    近年、放射線療法と免疫療法はその併用効果が高いことが報告され、頭頸部がんや肺がん等の多種類の悪性腫瘍で注目されている。現状では腫瘍抗原の一つであるPD-L1発現の有無を免疫染色で確認し治療効果を推測しているが、ヒトがん免疫応答を正確に再現する動物実験モデルはない。また抗PD-L1抗体に不応性の場合もしばしば経験され、特にそのような症例でどのような分子により腫瘍免疫が形成されているかの探索が重要である。我々はこれまで、前臨床試験モデルとして、患者由来のがん組織をマウスで増殖させるPatient-Derived Xenograftモデル（PDXモデル）を作製に成功してきた。このPDX腫瘍モデルは、患者由来の新鮮な腫瘍組織を用いているため、従来のがん細胞株をヌードマウスに移植した動物モデルでとは全く異なる特徴を持ち、より実臨床に近い重要な情報を検討することができる。本研究では、がん症例からの腫瘍組織を採取し、放射線感受性と、ヒトがん免疫応答を再現できる新規動物実験モデルを開発し、免疫応答に関連する新たな腫瘍抗原の探索など新規の放線免疫療法の開発に取り組む。このモデルは、患者個別の放射線感受性、ヒトがん免疫応答の研究、放射線療法との併用療法のトランスレーショナルリサーチに有用である。がんの前臨床試験やトランスレーショナルリサーチに使用する動物実験モデルとして、患者のがん組織を超免疫不全マウス（NOD/SID/IL2rgKOマウス：NSGマウス)に直接移植して継代培養する「患者由来がん異種移植マウスモデル(Patient-Derived Xenograft(PDX) mouse model)」が、広く活用されている。我々の 研究室ではPDXモデルの着手として、乳がんや大腸がん等の様々ながん種によるPDXモデルを精力的に作製してきた.

  • 小児・AYA世代の骨軟部肉腫に対する吸収性スペーサー併用陽子線治療の確立
    出水 祐介, 福本 巧, 佐々木 良平, 山下 智弘
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2020 - 31 Mar. 2023
    本研究におけるキーデバイスである吸収性スペーサーは、2019年12月にスペーサー留置術と共に保険適用となり、臨床現場で本格的に使われるようになった。 2022年4月末までに全国で累計155例に留置され、うち本研究の対象となる小児骨軟部肉腫症例は13例（8%）であった。尚、AYA世代骨軟部肉腫症例については、メーカーが症例の年齢内訳を公表していないため不明であるが、成人骨軟部肉腫症例は73例（47%）と約半数を占めており、AYA世代もそれなりにいると思われる。神戸陽子線センターにおいても17例に留置され、全国トップレベルの症例数であるが、うち15例が骨軟部肉腫症例、その中の4例が小児症例であった。 ①吸収性スペーサーの吸収過程のモデル化については、実際に多数の実臨床例を経験するとかなりバリエーションがあることが分かり、治験データ（5例）のみではよいモデルの作成は困難であると判断し、実臨床例も追加して作業をしている。PGA縫合糸が加水分解される際に発生するガス（二酸化炭素）のパターンについて解析し、学会発表を行ったほか、研究代表者（出水）および研究分担者（福本・佐々木）が中心となって2020年に立ち上げたスペーサー治療研究会にてメインテーマとして取り上げ、検討した。②過去の患者データを用いた陽子線治療計画シミュレーションに関しては、照射期間が長いユーイング肉腫において、スペーサーが吸収される前にboost照射（本来は照射期間の最後に行われる）を行うboost照射先行法を考案し、学会発表を行った。③他施設における吸収性スペーサー臨床症例データ収集については、現時点で吸収性スペーサー併用粒子線治療の経験がある全ての施設がスペーサー治療研究会に参加しているため、本研究会を通じて他施設のデータ収集が可能であると考えているが、新型コロナウイルス感染症の流行により他施設の訪問はできていない。

  • 獣医療における過酸化チタンナノ粒子を用いた新規・高精度放射線増感療法の開発
    長田 雅昭, 佐々木 良平, 椋本 成俊, 宮脇 大輔, 赤坂 浩亮
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2020 - 31 Mar. 2023
    放射線治療は人医療だけでなく、獣医療でも有効ながん・肉腫の治療手段である。獣医療分野では放射線照射の分割回数を増やせば、全身麻酔回数が増え、疾患動物への負担や侵襲も大きくなるという問題がある。放射線治療は、細胞に対して外因的にエネルギー付与により水の電離を介して活性酸素種(Reactive Oxygen Species, ROS)の発生が細胞傷害性を導くが、がん細胞自体も内因性のROSを持続的に発生し、その消去にためにグルタチオンやカタラーゼなどの還元系酵素の活性が上昇しており、通常のX線照射で発生するROSだけは相殺されてしまうため事が腫瘍の放射線抵抗性の原因と考えられる。申請者らは独自過酸化チタンナノ粒子をがん細胞内に取り込ませX線照射によりROSの著明な発生によって培養細胞やマウス腫瘍モデルにおいて優れた併用効果を確認しているが、今回の申請では種々の肉腫や猫の口腔内扁平上皮癌などの難治性腫瘍に罹患している犬や猫の実際の臨床例における過酸化チタンナノ粒子とIMRT技術を融合させた高精度放射線増感療法の開発とその検証を目的とする。昨年度の研究成果としては、がん細胞に高効率で過酸化チタンナノ粒子を輸送するシステムを確立したことである。そこで、過酸化チタンナノ粒子と最も広く報告されている金ナノ粒子を比較し、それぞれのラジカル産生能、その分子機序、抗腫瘍効果を検討し、その成果がNanomaterial誌に掲載された。またIn vivoでの過酸化チタンナノ粒子の動態とその生物学的評価を実施してその成果がColloids Surf B Biointerfaces誌に掲載された。さらに安定した過酸化チタンナノ粒子の生成方法を確立し、ナノ粒子の表面修飾の方法を改良中である。また最も重要なことを投与経路とその腫瘍への集積性を向上させることである。

  • Space making particle therapy for sarcoma and pediatric tumor
    SASAKI RYOHEI
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2019 - 31 Mar. 2022
    This study is to apply space-making therapy using absorptive spacer, which has been proved useful and safe in particle beam therapy. A Phase 1 clinical trial is planned to verify the consistent safety and efficacy of a series of treatment strategies from absorbable spacer placement in pediatric patients. The absorbable spacer was developed by our group and approved by the Pharmaceutical Affairs (Dec. 11, 2018), preparation of guidelines for proper use (May 2011-June), launch of the absorbable spacer (May 2011.06), and insurance adaptation for the absorbable spacer and its indwelling surgery (December 2019) Class IV medical devices have been clinically applied. The absorbable spacer has published the results of a first-in-human trial in particle beam therapy. Since then, its usefulness has attracted attention worldwide. Feasibility study in pediatic malignancies has been conducted.

  • Usefulness of exosome-derived PDL1 in radiation therapy
    HARADA AYA
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2019 - 31 Mar. 2022
    The purpose of this study is to evaluate usefulness of exosome-derived PDL1 as a biomarker in patients with unresectable non-small cell lung cancer treated wit curative chemoradiotherapy. We have obtained blood samples sequentially from patients with stage III non-small cell lung cancer. We have established quantitative methods to measure the exosome-derived PDL1, and have compared pre- and post-treatment blood samples with evaluating occurrence of tumor recurrence or tumor control.Then, we clarified possibilities whether the exosome-derived PDL1 could be an useful biomarker of effectiveness of curative chemoradiotherapy. Moreover, it seems another aspect and cutting edge view point to compare the exosome-derived PDL1 and soluble PDL1 in the serum.

  • Development of Theranostic particle beam therapy using titanium peroxide nanoparticles
    Akasaka Hiroaki
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2019 - 31 Mar. 2022
    We developed a novel titanium peroxide nanoparticles and reported that it generates a large amount of reactive oxygen species by X-ray irradiation and amplify the antitumor effect of radiation. Radiation causes cell death by generating reactive oxygen species (ROS) inside and outside the cell, but most radiation-resistant tumors overexpress antioxidants which have a ROS-scavenging effect. And, erasing ROS generated by radiation is one of the causes of intractability, and it is an issue for improving treatment results. A goal during this grant period was adding a drug delivery function to titanium peroxide nanoparticles to induce the target tumor with high efficiency and accuracy. Throughout the subsidy period, research on the addition of drug delivery capability to titanium peroxide nanoparticles has progressed significantly, and we have succeeded in developing a drug delivery system that efficiently transports titanium peroxide nanoparticles to cells expressing specific antibodies.

  • Nishimura Hideki
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2018 - 31 Mar. 2021
    The development of potentially safe radiosensitizing agents is essential to enhance the treatment outcomes of radioresistant cancers. The titanium peroxide nanoparticle (TiOxNP) was originally produced using the titanium dioxide nanoparticle, and it showed excellent reactive oxygen species (ROS) generation in response to ionizing radiation. Surface coating the TiOxNPs with polyacrylic acid (PAA) showed low toxicity to the living body and excellent radiosensitizing effect on cancer cells. Herein, we evaluated the mechanism of radiosensitization by PAA-TiOxNPs in comparison with gold nanoparticles (AuNPs). PAA-TiOxNPs showed a significantly more radiosensitizing effect than that of AuNPs. A comparison of the types and amounts of ROS generated showed that hydrogen peroxide generation by PAA-TiOxNPs was the major factor that contributed to the nanoparticle radiosensitization.
    Competitive research funding

  • Inubushi Sachiko
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2018 - 31 Mar. 2021
    The precise mechanism of intercellular communication between cancer cells following radiation exposure is unclear. The present study aimed to identify novel roles of exosomes released from irradiated cells to neighboring cancer cells.Further analysis using miRNA mimics and reverse transcription-quantitative PCR identified miR-6823-5p as a potential candidate to inhibit SOD1, leading to increased intracellular ROS levels and DNA damage. The present study is the first to demonstrate that irradiated exosomes enhance the radiation effect via increasing intracellular ROS levels in cancer cells.
    Competitive research funding

  • Okada Takuya
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2017 - 31 Mar. 2020
    Twelve female rabbits with VX2 thigh tumors were divided into the three groups: Intraarterial (IA), balloon occlusion arterial (BOA), and intravenous (IV) infusion groups. 10 ml of PAA-TiOx NPs (10 mg/ml) were infused through an external iliac artery in the IA and BOA groups and a marginal ear vein in the IV group. The median accumulation rates of PAA-TiOx NPs in VX2 tumor were 0.119, 0.078 and 0.117 weight percent, and the median concentration of NPs in VX2 tumor was 0.0026, 0.0015, and 0.0034 mg/g tissue in the IA, BOA and IV groups, respectively. There were no statistically differences between the IA and IV groups, and nor between the BOA and IV groups. PAA-TiOx NPs accumulated most in liver at 10.9306, 16.2188 and 25.7768 weight percent, and second most in spleen at 0.8686, 0.7624 and 2.4372 weight percent in the IA, BOA and IV groups. Intraarterial infusion did not increase the accumulation of PAA-TiOx NPs in VX2 tumor compared with intravenous infusion.
    Competitive research funding

  • Kakeji Yoshiriho
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2016 - 31 Mar. 2020
    We investigated the effects of preoperative therapy on the tumor immune microenvironment in esophageal cancer surgery after preoperative chemotherapy and rectal cancer surgery after preoperative chemoradiotherapy. We showed the prognostic impact of the expression levels of immune-related molecules. Besides, we created a radiation mouse model using the CT26 colorectal cancer cell line. We found that intratumoral T cells were markedly increased after radiotherapy. Many of these T cells were PD-1+Tim-3+, suggesting a significant increase in tumor-reactive T cells. We want to investigate the mechanism of this change and use it to improve surgical outcomes during preoperative treatment.
    Competitive research funding

  • Ogino Chiaki
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2016 - 31 Mar. 2019
    In present study, the size of PAATiOx nanoparticle is effective for accumulation in tissue, and 20nm nanoparticle could not be trapped by the liver than at 100 nm, and its accumulation effect to the tumor is also high. It was also shown that PEG modification is less likely to be trapped in the liver than that by PAA modification. Therefore, in the future, it is necessary to antibody modified PEG-modified PAATiOx, and to evaluate retention effect in blood, pharmacokinetics, and accumulation rate into a target tumor. Moreover, since the dominant radiosensitization effect was confirmed by multiple combination treatment with X-rays irradiations, this clinical application can be expected by examining a treatment protocol with more effective than existing X-ray therapy strategy.
    Competitive research funding

  • SASAKI RYOHEI
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2016 - 31 Mar. 2019, Principal investigator
    We have developed a novel bioabsorbable polyglycolic acid (PGA) spacer. This is a promising method designed to allow for increased tumor dose while limiting exposure to adjacent organs without remaining a foreign body after the treatment. In the preclinical animal study, biological safety was evaluated, resulting that no weight loss or appetite loss was observed. There were minimum adhesion, and a Seprafilm helped to decrease those adhesions. With long term observation in animals, the PGA spacer was slowly decreased in size and seemed to be useful and safe for clinical application Then, a first-in-human phase I clinical study using the PGA spacer aimed to evaluate the safety and efficacy of SMPT in patients with unresectable malignant tumor located adjacent to normal organs.
    Competitive research funding

  • SASAKI RYOHEI
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Kobe University, 01 Apr. 2016 - 31 Mar. 2019, Principal investigator
    Polyacrylic acid (PAA)-modified titanium peroxide nanoparticles (PAA-TiOxNPs) are promising radiosensitizers. PAA-TiOxNPs were synthesized from commercial TiO2 nanoparticles that were modified with PAA and functionalized by H2O2treatment. To realize practical clinical uses for PAA-TiOxNPs, their tissue distribution and acute toxicity were evaluated using healthy mice and mice bearing tumors derived from xenografted Mhuman pancreatic cancer cells. Such high accumulation could be associated with enhanced permeability and retention effects of the tumor, as PAA-TiOxNPs are composed of inorganic particles and polymers, without tumor-targeting molecules.
    Competitive research funding

  • MIYAWAKI Daisuke
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2015 - 31 Mar. 2018
    Ultrahigh dose-rate, "FLASH" micro-slit-beam irradiation shifted by a large factor the threshold dose required to initiate lung fibrosis without loss of the antitumor efficiency, suggesting that the method might be used to advantage to reduce the occurrence and severity of early and late complications affecting normal tissue.
    Competitive research funding

  • Okamoto Yoshiaki
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2015 - 31 Mar. 2018
    Effective methods to ameliorate radiation enteropathy have not been developed. To address this issue, reduced CoQ10 was investigated as a potential radioprotective, functional dietary supplement.Reduced CoQ10 was accumulated in all sections of the intestine in supplemented mice. Supplementation with CoQ10 was contributed to suppressing production of reactive oxygen species and inhibiting apoptosis in the crypts, leading to preservation of villi structures after the irradiation. Metabomic analyses were performed. Reduced CoQ10 seemed to be a candidate for amelioration of radiation enteropathy
    Competitive research funding

  • 先端医療機器の開発/高い安全性と更なる低侵襲化及び高難度治療を可能にする軟性内視鏡手術システムの研究開発
    佐々木 良平
    学校法人慶応義塾, 未来医療を実現する医療機器・システム研究開発事業, 2017, Principal investigator
    Competitive research funding

  • EJIMA YASUO, SASAKI Ryohei, YOSHIDA Kenji, MIYAWAKI Daisuke, OSUGA Saki, INUBUSHI Sachiko, MUKUMOTO Naritoshi, AKASAKA Hiroaki, SHIMIZU Yasuyuki, UCHIDA Ray
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2013 - 31 Mar. 2016
    Protection of normal structure of the intestine is important under intense radiation therapy. We focused on the reduced form of Coenzyme Q10 (reduced-CoQ10), which is an antioxidant and naturally available in the human body, and examined its radioprotective effect on the small intestine of mice. Reduced-CoQ10, when administered orally, diminished the radiation-mediated damage of villi and apoptosis in intestinal crypt cells, and also reduced reactive oxygen species (ROS) production upon irradiation. In contrast to that in normal cells, reduced-CoQ10 did not diminish the cytotoxic effects of irradiation in tumor cells in vitro, but decreased their survival by increasing ROS production. Further, to clarify the metabolic changes induced by reduced-CoQ10 and irradiation, metabolomics analysis of mice serum and intestinal tissue samples was performed. Metabolomic profiling identified taurine as a potential biomarker for radiation-mediated damage of the intestine.
    Competitive research funding

  • Nishimura Hideki, SASAKI Ryohei, YOSHIDA Kenji
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2013 - 31 Mar. 2016
    Micro beam radiation therapy (MRT) allows for extremely high-dose irradiation. However, the toxicity of MRT in central nervous system (CNS) is still unknown. We evaluated mortality in normal mice following CNS-targeted MRT. MRT using synchrotron X-ray beam was performed using BL28B2 beam-line at the SPring-8 facility. Fifty percent lethal dose by the 300 micrometer spacing MRT was 600 Gy. Our results indicated that the MRT enable to deliver extremely high doses without loss of normal brain function. Our results suggest that normal tissue damage in MRT is related to the valley dose in regardless of the peak dose and peak valley dose ratio.
    Competitive research funding

  • SASAKI RYOHEI, FUKUMOTO Takumi, EJIMA Yasuo, NISHIMURA Hideki, YOSHIDA Kenji, MIYAWAKI Daisuke, UEZONO Haruka, AKASAKA Hiroaki, MUKUMOTO Naritoshi
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2013 - 31 Mar. 2016, Principal investigator
    Non-woven fabric bioabsorbable spacer consisted of surgical polyglucolic acid (PGA) sutures has been originaly invented. Characteristics and safety was intensively examined,and animal studies were performed without severe toxicity. The ability of the PGA spacer is to keep its thickness more than 85% for 8 weeks. The spacer reduced gradually, however, it did not cause any toxicity. Clinical study has been started to elucidate efficacy and safety of this spacer for particle therapy
    Competitive research funding

  • Yoshida Kenji, SASAKI Ryohei, NISHIMURA Hideki
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2013 - 31 Mar. 2016
    Image guided brachytherapy (IGBT) has been introduced for the treatment of cervical cancer. By using IGBT, precise treatmet can be done and prpblems to be improved in the dose reduction of organs at ris were clarified. The purpose of this study is to create the new vaginal spacer to decrease the rectal dose for the clinical treatment. However, not only the spacer, new applicator, which is suitable for the Asian was turned out to be indispensable for the completion of our aim during the development of spacer. Threofore, we have to combine these two creations and now we have been creating these two devices.
    Competitive research funding

  • OGINO Chiaki, SASAKI Ryouhei
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2013 - 31 Mar. 2016
    Titanium peroxide nanoparticles (TiOxNPs) was synthesized and their efficacy as novel agents that can potently enhance the effects of radiation in the treatment of pancreatic cancer was investigated. The core structures of the PAA-TiOxNPs were found to be of the anatase type. The TiOxNPs and PAA-TiOxNPs showed a distinct ability to produce hydroxyl radicals in response to X-ray irradiation in a dose- and concentration-dependent manner, whereas the TiO2NPs did not. The combination of the PAATiOxNPs and X-ray irradiation induced significantly stronger tumor growth inhibition compared to treatment with either PAA-TiOxNPs or X-ray alone. In addition, bio-distribution of PAATiOx in Xenograft mouse model was identified, and the evaluation method of effect of X-ray irradiation on cell line was also established. Together these findings, TiOxNPs are potential agents for enhancing the effects of radiation on pancreatic cancer via hydroxyl radical production.
    Competitive research funding

  • Kohmura Eiji, SASAYAMA Takashi, TANAKA Kazuhiro, HOSODA Koukichi, MIZUKAWA Katsu, SASAKI Ryohei
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2013 - 31 Mar. 2016
    In this study, we aimed to determine the additional value of other metabolites in predicting IDH1 mutations with conventional MRS. RESULTS: A metabolomic analysis demonstrated higher levels of 2HG in IDH1 mutant glioma cells and surgical tissues. Interestingly, glutamate levels were significantly decreased in IDH1 mutant gliomas. Through an analysis of metabolic enzyme genes in glutamine pathways, it was shown that the expressions of branched-chain amino acid transaminase 1 were reduced and glutamate dehydrogenase levels were elevated in IDH1 mutant gliomas. Conventional MRS detection of glutamate and 2HG resulted in a high diagnostic accuracy (sensitivity 72%, specificity 96%) for IDH1 mutant glioma. CONCLUSIONS: IDH1 mutations alter glutamate metabolism. Combining glutamate levels optimizes the 2HG-based monitoring of IDH1 mutations via MRS and represents a reliable clinical application for diagnosing IDH1 mutant gliomas.
    Competitive research funding

  • SASAKI RYOHEI, OGINO Chiaki, SATO Kazuyoshi, NUMAKO Chiya, NAKAYAMA Masao, AKASAKA Hiroaki
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Kobe University, 01 Apr. 2013 - 31 Mar. 2016, Principal investigator
    The tumor growth inhibitory effects ofPAA-TiOx nanoparticles combined with X-ray irradiation was observed in vitro and in vivo experiments.The effect was induced by ROS generation followed by DNA damages in cancer cells. Evaluations of long-term toxicity and of molecular mechanisms need to be performed in the nearest future. This strategy might be a novel radiosensitization method using metal nanoparticles
    Competitive research funding

  • （AMED）先端医療機器の開発/高い安全性と更なる低侵襲化及び高難度治療を可能にする軟性内視鏡手術システムの研究開発
    佐々木 良平
    国立研究開発法人新エネルギー・産業技術総合開発機構, 未来医療を実現する先端医療機器・システムの研究開発, 2016, Principal investigator
    Competitive research funding

  • OKAMOTO Yoshiaki, SASAKI Ryohei, YOSHIDA Kenji, MIYAWAKI Daisuke, FURUSE Motomasak
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2012 - 31 Mar. 2015
    This study was prformed at Spring-8, Hyogo Japan, using synchrotron radiation. Normal tissue tolerance to ultra-high dose rate radiation was examined using C57/BL6 mice brain in vivo. The comparison between broad beam and several slit beams irradiation revealed that a LD50 of slitbeam (500 Gy)achieved approximately 7-folds higher than that of broad beam(70 Gy). Moreover, the slit beam irradiation did not cause severe neuronalcells loss. The slit beam irradiation to the brain did not induce abnormal behavior disorder in mice. The slit beam irradiation to the spinal cord did not cause any difference to that of broad beam irradiation.
    Competitive research funding

  • 吸収性スペーサーを用いた体内空間可変粒子線治療の有用性と安全性の検討/陽子線治療による吸水性スペーサーの有用性と安全性の検討
    佐々木 良平
    日本医療研究開発機構, がん対策推進総合研究事業革新的がん医療実用化研究事業（患者に優しい新規医療技術開発に関する研究）, 2015, Principal investigator
    Competitive research funding

  • Not only angiogenesis but also inflammation participate in the pathophysiology of brain radiation necrosis
    MIYATAKE Shin-Ichi, SASAKI Ryohei
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Osaka Medical College, 01 Apr. 2012 - 31 Mar. 2014
    Surgical specimens of symptomatic RN in the brain were retrospectively reviewed by histological and immunohistochemical analyses using hematoxylin and eosin (H&E) staining as well as immunohistochemical staining.The most prominent vasculature was identified as thin-walled leaky angiogenesis, i.e., telangiectasis surrounded by prominent interstitial edema.Two major cell phenotypes infiltrated the perinecrotic area: GFAP-positive reactive astrocytes and CD68/hGLUT-5-positive cells (mainly microglias). VEGF caused leaky angiogenesis followed by perilesional edema in RN. GFAP-positive cells expressing CXCL12 might attract CXCR4-expressing CD68/hGLUT5-positive cells into the perinecrotic area. These accumulated CD68/hGLUT5-positive cells expressing pro-inflammatory cytokines seemed to aggravate the RN edema. Both angiogenesis and inflammation might be caused by the regulation of HIF-1a, which is well known as a transactivator of VEGF and of the CXCL12/CXCR4 chemokine axis.

  • 井上 真理
    科学研究費補助金／萌芽研究, Apr. 2011 - Mar. 2013
    Competitive research funding

  • SASAKI Ryohei, YAMAMOTO Yasuji
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, Apr. 2010 - Mar. 2013, Principal investigator
    We peformed clinical trials against higher brain dysfunction after radiation therapy. Among this period, 4 cases were enrolled in this study. There were a patient with glioblastoma, a patient with low grade glioma, a patients with CNS lymphoma, and a patient with metastatic brain tumor. There were 3 male and 1 female patients. They were 30, 67, 72 years old, respectively. Radiation fields were set as whole brain irradiation in 2 patients, and localized fields in other 2 patients. Radiation doses were ranging from 30-60 Gy. Efficacy of donepezil HCl were observed in all cases. There were no case who experienced more than Grade 2 morbidity. In conclusion, donepezil HCl seemed to be effective and safe treatment option against higher brain dysfunction after radiation therapy
    Competitive research funding

  • MURAOKA OSAMU, FUKUMOTO Takumi, YOSHIDA Kenji
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 2011 - 2013
    Originally invented nonwoven fabric polyglycolic acid (PGA) spacer was tested by physical experiment and animal experiments. The PGA spacer exhibits excellent properties related to bio-absorbability, bio-compatibility, and thickness retention. Adhesion of the PGA spacer was minimum and blood test indicated that there was no inflammatory reaction. The retension of the PGA spacer depends upon its density. These findings should be more intensively investigated for the clinical application. The PGA spacer will be a useful method for particle therapy without damaging adjacent organs.
    Competitive research funding

  • The development of the clothing for improving the quality of life for uterine cancer patients
    INOUE Mari, SASAKI Ryohei, YOSHIDA Kenji
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Kobe University, 2011 - 2012
    We studied about the development of the clothing for improving the quality of life for the patients which is receiving radiation with the radiotherapists and engineers for radiation treatment. And we could make the reliable clothing with good handle for the patients.

  • Efficacy of donepezil HCl to higher brain dysfunction after radiation therapy
    SASAKI Ryohei, YAMAMOTO Yasuji
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 2010 - 2012
    We peformed clinical trials against higher brain dysfunction after radiation therapy. Among this period, 4 cases were enrolled in this study. There were a patient with glioblastoma, a patient with low grade glioma, a patients with CNS lymphoma, and a patient with metastatic brain tumor. There were 3 male and 1 female patients. They were 30, 67, 72 years old, respectively. Radiation fields were set as whole brain irradiation in 2 patients, and localized fields in other 2 patients. Radiation doses were ranging from 30-60 Gy. Efficacy of donepezil HCl were observed in all cases. There were no case who experienced more than Grade 2 morbidity. In conclusion, donepezil HCl seemed to be effective and safe treatment option against higher brain dysfunction after radiation therapy

  • Clinical trials for the establishment of standard radiation therapy methods and the selection of radiosensitive tumors in early cancer patients
    YAMADA Shogo, NISHIMURA Yasumasa, HAREYAMA Masato, HAYABUCHI Naohumi, SHIBAMOTO Yuta, SHIRATO Hiroki, NAKAMURA Kazumasa, ONISHI Hiroshi, TOITA Takahumi, ARIGA Hisanori, SASAKI Ryohei, TESHIMA Syoki, TAKAI Yoshihiro, NISHIO Teiji, MURAKAMI Masao, HIRAOKA Masahiro, KAMATA Tadashi, OHUCHI Noriaki, DOBASHI Suguru, JINGU Keiichi, MATSUSHITA Haruo, SHIMIZU Shinichi, HUKAO Akira, MORIYA Takuya, OGAWA Yoshihiro
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Tohoku University, 2009 - 2012
    The progress of diagnostic imaging enables early detection of cancers. The importance of radiation therapy for early cancers is increasing for the better QOL of patients. However, standard radiation therapy methods for these curable cancers have not yet been established. We collected data of early cancers treated by radiation therapy in Japan to propose treatment methods to be considered as standard. And we also carried out prospective clinical trials for the establishment of standard radiation therapy methods and a study of the selection of radiosensitive tumors in early cancer patients.

  • Chemoradiotherapy targeting autophagy mechanism against pancreas cancer.
    OKAMOTO Yoshiaki, SASAKI Ryohei, SUGIMURA Kazuro, NISHIMURA Hideki, YOSHIDA Kenji, SUZUKI Yoko, TSUJIMURA Toshiaki
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 2009 - 2011
    Autophagy is one of the most important intraceller mechanism to radiation and chemotherapy. In this study, we evaluated induction of the autophagy by using human pancreas cancer cells. Autophagy was assessed by electron microscope, western blotting of LC-3. In vivo experiment, gemcitabine and ionizing radiation resulted in synergistic cytotoxicity with induction of autophagy.

  • Study on enhancement of human cancer cell radiosensitivity by conjugated eicosapentaenoic acid
    MIZUSHINA Yoshiyuki, SASAKI Ryohei
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Kobe Gakuin University, 2009 - 2011
    We found that conjugated eicosapentaenoic acid(cEPA), which is a major fish oil, had anti-cancer activity based on DNA polymerase inhibition. In human colon cancer cells, the post-irradiation addition of cEPA significantly enhanced cancer cell radiosensitivity and apoptosis. cEPA also enhanced the suppression of human colon cancer cell growth by gemcitabine, which is a major clinical anti-cancer drug. cEPA could be a anti-cancer enhancer for radiotherapy and chemotherapy.

  • 岡本 欣晃
    科学研究費補助金／基盤研究(C), 2011
    Competitive research funding

  • INOUE Mari, SASAKI Ryohei, OKAMOTO Yoshiaki, KOUNO Seishi, YOSHIDA Kenji
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 2010 - 2010
    For the development of the garment wearing during receiving radiation treatment for the patients with breast or uterine cancer, doctors specialized in radiology and mammary gland, nurses, radiological technologists, specialist in clothing science discussed about the necessary condition of the garment, clothing material, hand, wearing comfort, design and produced the trial garments.
    Competitive research funding

  • Basic Comparison of Biological Effects between Protons and Carbon-Ions
    HISHIKAWA Yoshio, MURAKAMI Masao, SASAKI Ryohei, DEMIZU Yusuke
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Kobe University, 2008 - 2010
    Particle therapy using protons or carbon-ions showed higher effectiveness than conventional X-ray therapy on basic research basis. A new finding was obtained that generation of reactive oxygen species (ROS), which plays an important role in biological effects of radiation, was not temporary but continuous after irradiation. It was also found that continuous suppression of ROS by N-acetylcysteine (NAC) lead to increased cell survival after irradiation. NAC could be used as a radioprotective agent in clinical settings.

  • Development of the garment wearing during receiving radiation treatment for the patients with breast or uterine cancer
    INOUE Mari, SASAKI Ryohei, OKAMOTO Yoshiaki, KOUNO Seishi, YOSHIDA Kenji
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 2008 - 2010
    For the development of the garment wearing during receiving radiation treatment for the patients with breast or uterine cancer, doctors specialized in radiology and mammary gland, nurses, radiological technologists, specialist in clothing science discussed about the necessary condition of the garment, clothing material, hand, wearing comfort, design and produced the trial garments.

  • 菱川 良夫
    科学研究費補助金／基盤研究(B), 2010
    Competitive research funding

  • Redox-moduIated functional foods for protection of radiation-induced gastrointestineal damage
    OKAMOTO Yoshiaki, SASAKI Ryohei, SUGIMURA Kazuro, NIBU Kenichi, YOSHIDA Suguru, MIZUSHINA Yoshiyuki, NISHIMURA Hideki
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 2007 - 2008
    レドックスを可変させる物質としてVitamin K3を用いてフリーラジカルを発生させ、癌細胞と正常細胞に与える影響に関して検討した。Vitamin K3は少量ではミトコンドリア呼吸機能を可変させ、多量では急激な細胞死を来す結果も得た。一方で類似構造を持ち、食品にも含まれるVitamin K1はレドックスをあまり可変させず、癌細胞、正常細胞ともに細胞死を誘導しない。また同様に類似構造を持つVitamin K2では一部の癌細胞では細胞死を誘導した。

  • Clinical trials for the establishment of standard radiation therapy methods for early cancers
    YAMADA Shogo, HAREYAMA Masato, NAKAMURA Kazumasa, SIRATO Hiroki, NEMOTO Kenji, NISHIMURA Yasumasa, HAYABUCHI Naohumi, ONISHI Hiroshi, TESHIMA Teruki, OGAWA Yoshihiro, OUCHI Noriaki, MORIYA Takuya, ARIGA Hisanori, NAKATA Eiko, HUKAO Akira, ABE Yoshinao, TOITA Takahumi, TSUJII Hirohiko, SHIBAMOTO Yuta, SASAKI Ryohei, HISHIKAWA YOSHIO
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Tohoku University, 2006 - 2008
    画像診断の進歩により早期の癌が高率に発見されるようになり、またQOL重視の風潮の中で早期のがんに対する放射線治療の役割が急増している。しかし、治癒の可能性の高いこれらの癌に対する標準的放射線治療方法はいまだ確立していない。私どもは種々の早期のがんに対して全国集計を行い、結果を解析し、標準的と考えられる治療方法を提示してきた。さらに、標準的治療方法確立のために種々の臨床試験の提案を行い、実行してきた。

  • 西口 直希
    科学研究費補助金／基盤研究(C), 2008
    Competitive research funding

  • 岡本 欣晃
    科学研究費補助金／基盤研究(C), 2008
    Competitive research funding

  • Research of significance of AKT for the radioresistant mechanisms in normal and malignant tissue
    OKAMOTO Yoshiaki, SUGIMURA Kazuro, NIBU Kenichi, SASAKI Ryohei, KAWASAKI Ryota, OTA Yosuke
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 2005 - 2006
    Significance of AKT in the radioresistant mechanism has not been clarified. In this study, Free radical mediated AKT activation and NF-kappa B activation were closely related to the radioresistance in both normal and malignant cells. Especially, Pelicano and Sasaki have reported that mitochondrial respiratory function communicated with AKT activation through free radical, and the communication led to the invasiveness of the tumor or chemosensitivity. Demizu and Okamoto have reported that effectiveness of cisplatin-based concurrent chemoradiotherapy in patients with nasopharyngeal carcinoma, and clinical outcomes of the treatment as a preliminary report. In the present study, we have found there are certain percentage of patients who experienced their poor outcomes. Moreover, we are now investigating that the relationships between resistance to the anticancer treatment and the AKT activation, as well as p53, NF-kappa B. Ejima and Okamoto have reported that outcomes of MALT lymphoma of the orbita in the journal of Radiotherapy and Oncology. In the study, prognostic factors and adverse effects were clarified from the analysis, in the same time. For this disease, prognostic factors have not been determined. Therefore, candidates for molecular mechanisms of radioresistance, such as AKT, p53 BCL-10, were also assessed. Those results were now preparing for another submission. Thus, the significance of AKT in the radioresistant mechanism were investigated in the multiple situation. In vitro study, and clinical investigation were performed, leading to the fact that AKT was one of the important candidate for molecular mechanisms of intracellular radioresistance.

  • Research for serum markers of radiosensitivity from cancer patients
    TANIGUCHI Takanori, SUGIMURA Kazuro, OKAMOTO Yoshiaki, SASAKI Ryohei, OTA Yosuke
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 2005 - 2006
    To search for novel serum markers of radiosensitivity for the cancer patients, we correlate the patient outcomes and the proteome phenotype from patients' serum. Demizu et al. reported the Efficacy and feasibility of cisplatin-based concurrent chemoradiotherapy for nasopharyngeal carcinoma in Japanese Journal Clinical Oncology. Ejima et al. reported Ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy in Radiotherapy and Oncology.

  • 放射線感受性・分子標的としてのp53蛋白のミトコンドリアゲノム制御機能
    佐々木 良平
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Kobe University, 2005 - 2006
    Pelicanoと申請者である佐々木等は、共同研究の中でミトコンドリアの呼吸機能がAktによって深く制御されており、それが癌の悪性度や抗がん剤の反応に深く関与するという実験結果を得て、その研究成果がJ Cell Biolに掲載された。 出水と申請者である佐々木等は、上咽頭癌の放射線化学療法における治療効果をJapanese Joural of Clinical Oncologyに報告した。一連の検討成果の中で第一段階として治療成績に関して報告したが、更に上咽頭癌においてもp53などミトコンドリアゲノムを制御する分子が抗腫膓効果に深く関与する可能性を見出し、現在その成果を更に探求している。 江島と申請者である佐々木等は、眼窩発生のMALTリンパ腫の放射線療法における治療効果をRadiotherapy and Oncologyに報告した。同様に一連の検討成果の中で第一段階として治療成績に関して報告したが、更に本疾患ではp53,Bc110などミトコンドリアのアポトーシス制御に深くする分子が放射線治療効果に深く関与する可能性を見出し、NK-KBとの関連も含めて、現在その成果を更に探求している。 出水と申請者である佐々木等は、タバコ中の主たる発がん物質であるNNKを肺上皮細胞に作用させ、悪性転化した肺癌細胞の樹立に成功した。それらの細胞株を詳細に検討した結果、細胞はp53変異型であり、ミトコンドリアゲノムの不安定が顕著であり、様々なミトコンドリア内の抗酸化酵素の発現が著明に更新していることが確認された。その研究成果をInternational Journal of Radiation Oncology, Biology, Physicsに報告した。P53機能が十分でない細胞でのミトコンドリアゲノム不安定性が悪性転化する理想的な細胞モデルと想定され、更なる機能解析を進める予定である。

  • 谷口 尚範
    科学研究費補助金／基盤研究(C), 2006
    Competitive research funding

  • 岡本 欣晃
    科学研究費補助金／基盤研究(C), 2006
    Competitive research funding

  • 佐々木 良平
    科学研究費補助金／若手研究(B), 2006, Principal investigator
    Competitive research funding

  • Research of Proton and Carbon ion bean irradiation and its diagnostic methods
    SUGIMURA Kazuro, FUJII Masahito, KAJI Yasushi, KUROSAKA Masahiro, HISHIKAWA Yoshio, SASAKI Ryohei
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Kobe University, 2003 - 2004
    Proton beam or carbon ion beam irradiation are known to have achieved their excellent dose distribution. However, their biological and molecular difference are largely unknown. Hyogo Ion Beam Center is the first to have both proton and carbon ion beams in the world. With using these advantages, we firstly report that both proton and carbon ion beams could repress metastatic ability, not only their cytotoxicity.(Cancer Res, 2005;65(1): 113-120) In the next, we reported that photon and carbo ion beam showed additive effect in vitro (Radiother and Oncol. 2004;71(2):207-211). Moreover, we investigated several diagnostic methods for more accurate diagnosis to improve outcomes. Especially, FDG-PET have powerful prognostic ability in the management of non-small cell lung cancer (J Clin Oncol, 2005; 23(6): 1136-1143). MRI also showed sharp diagnostic accuracy with using STIR turbo spin-echo (Radiology, 2004;231(3):872-9)

  • Research of increase radiosensitivity targeting DNA repair mechanism in treatment-resistant cells
    SASAKI Ryohei, SUGIMURA Kazuro, ONO Yoshiharu, MURAKAMI Masao
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 2003 - 2004
    Inhibition of Rad51, a DNA repair protein in homologus recombination after DNA damage, leads to an increase of radiosensitivity in prostate cancer cells in vitro. In this study, we used several antisense oligonucleotide to decrease Rad51 protein function, and evaluate Rad51 dysfunction with using comet assay, which is an analysis for DNA repair ability after DNA damage. In the next step, we first established several radioresistant clones from parental colon cancer cell lines (HCT116 p53+/+, p53 -/-). We are now applying Rad51 inhibition to those sets of parental and radioresistant clones. On the other hand, we investigated an novel combination therapy, which are consisted of natural product of isoflavinol and ionizing radiation. We found that treatment of an isoflavinol, genistein, increase radiosensitivity in radioresistant prostate cancer cells by promoting apoptosis (Asian J Androl. 2004;6(4):285-290.) To apply these findings, we investigated efficacy of FDG-PET in non-small cell lung cancer as an clinical model. We found and reported that tumor in which FDG were accumulated showed radioresistant characteristics, and metastatized frequently.(J Clin Oncol. 2005;23(6): 1136-1143).

  • INNOVATION FOR TISSUE-SPECIFIC RADIO-SENCITIZATION OF SELECTIVE INHIBITOR OF CYCLO-OXYGENASE 2 (COX-2)
    MATSUMOTO Akira, SASAKI Ryohei, SOEJIMA Toshinori, SUGIMURA Kazuro, KISHI Kazufumi, DOTO Akinobu
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), 2002 - 2003
    It is a well-known fact that there iis a great difference in radiosensitivity between actively replicating tumor cell and differentiated neurons without replicating activity. In this research project, we focused on cyclo-oxygenase 2 (COX-2) inhibitors, whose inhibitory action of cell replication is recognized in many tumor cell linse, and carboxypeptidase B (HBCPB) which exhibits inhibitory activity for cell toxicity be dissociation of beta-amyloid oligomer, and snslyzed their functions with regard to apoptosis induction. COX-2 study : Using human hemangiosarcoma cell line (ISO-HAS), following analyses were performed. Effects in tumor growth and angiogenesis by co-usage of irradiation and NS-389, a selective COX-2 inhibitor. Relationship of COX-2 effect and VEGF protein expression. As for results, cell viability was decreased by NS-389 in a dose dependent fashion, and the VEGF-protein expression was increased by irradiation also in a dose-dependent manner, which was inhibited by co-usage of NS-398. Therefore, it seems that NS-389 has a co-usage effect with irradiation, and its cell growth inhibitory effect is relevant to VEGF. HBCPB study : As a typical example of non-replicating cell, using rat hippocampus primary neuron culture system was used. In this system, neuro-toxicity of beta-amyloid 1-42 oligomer, and its dissociation by human brain carboxypeptidase B (HBCPB) were analyzed especially with respect to apoptosis induction. As a result, this system induced no effects in the COX-2 prostaglandin lineage, and suggests that these are independent regulation system for selective cell death to keep homeostasis.

  • 拡散強調MRI及びMRSによる遺伝子治療の生体内効果伴定法の開発
    杉村 和朗, 後藤 章暢, 楫 靖, 副島 俊典, 佐々木 良平
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Exploratory Research, Grant-in-Aid for Exploratory Research, Kobe University, 2002 - 2003
    我々は前立腺癌に対するアデノウイルスを用いた遺伝子治療・放射線療法の併用療法の分子機序の解明を成功させ,その成果をH13年の米国癌学会(AACR)や,H12年の米国,欧州放射線腫瘍学会(ASTRO, ESTRO)において報告してきた。それら一連の研究成果の中で,特に放射線抵抗性腫瘍に併用効果が高いことや,p53遺伝子の変異型によって遺伝子の導入効率は同じでも治療効果が異なること,放射線照射によるDNA損傷が遺伝子導入効率を著明に向上させること等,大きな3つの新知見を得てきた。今年度はさらに複数数の癌細胞腫においてp53が細胞周期停止およびアポトーシスを誘導することによって放射線照射の効果を高めることを確かめた。そして新たにp21遺伝子を導入する手法を開発し,その効果についてin vitro, in vivoでの検討を行った。正常型p21遺伝子導入によって腫瘍細胞の増殖は抑制され,これはG1期での細胞周期停止による効果であることを明らかにすると共に,in vivoにおいては正常型p21遺伝子が腫瘍細胞の生着率を低下させることを明らかにした。そしてこれらの効果はアンドロゲン依存性,非依存性腫瘍のいずれにおいても同等であった。また,これら遺伝子治療の臨床での効果評価法としてMRS撮像法も同時に開発中であるが,良好な信号を得るために必要な直腸内コイルは不快感があるためにルーチンには用いにくいという問題点がある。そこで我々はphased-arrayコイルを用いた2-Dimentional Chemical Shift Imaging (2D CSI)法と直腸内コイルを用いた場合との前立腺癌の診断能を比較し,遜色ない結果が得られることを明らかにした。今後これらを融合させ,遺伝子導入の効異について検討をする予定である。

  • Estimation of Biologic and Molecular Aspects of Heavy Charged Particle Therapy for Cancer Cells
    SUGIMOTO Kouji, GOTO Akinobu, SOEJIMA Toshinori, SUGIMURA Kazurou, MATSUMOTO Akira, KAJI Yasushi
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University Graduate School of Medicine, 2001 - 2002
    Carbon ion irradiation has well-balanced dual actions on cancers : efficient doselocalization due to sharp penumbra and distal taill off in dose, and potent biological anticancer effect due to high relative biological effect (RBE). However, biological and molecular mechanisms of carbon ion irradiation have not been clarified. In this study, we focused on the biologic mechanisms of carbon ion irradiation, especially assessing DNA double strand breaks (DSBs) and repair. Cell-killing effect of X-ray and carbon ion irradiation was assessed using a colony-formation assay. The amount of double strand breaks and repair rate was assessed by comat assay. In the comparison of DSBs repair between carbon ion irradiation and X-ray irradiation, the degree of residual DSBs was severe in carbon ion irradiated cells. The expression level of DSB repair associated protein was assessed by Westem blot analysis. Sub-nuclear localization of DNA repair protein Rad51 were immunohistochemically evaluated via epitluorescence microscopy. Rad51 nuclear foci formation was observed after X-ray irradiation and carbon ion irradiation. These nuclear foci in the cells treated with carbon ion were sustained to 24 hours after irradiation, whereas in the cells treated with X-ray irradiation more than half of nuclear foci were disappeared at 24 hours after irradiation. Rad51 antisense oligonucleotides was transfected and irradiated with carbonions. Clonogenic assay after transfection revealed that Rad51 antisense oligonucleotides increased radiosensitivity very little carbon ion irradiation, whereas ti increased about 1.7 fold in X-irradiation. Comet assay was also performed for quantitative analysis of DSB induction and repair. There was no difference of DSB induction and repair rate after carbon ion irradiation in the cells treated with Rad51 antisense oligonucleotides and with control oligos. These results may suggest that carbon-ion-induced DSBs are difficult to be repaired by homologous recombination.

  • Efficacy of Combination Therapy of Ionizing Radiation and Gene Therapy in Prostate Cancer in vitro
    SOEJIMA Toshinori, SHIRAKAWA Toshiro, GOTOH Akinobu, SUGIMURA Kazuro
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University Graduate School of Medicine, 2000 - 2002
    Several studies have demonstrated that the function of the p53 gene is one of the major determinants of intrinsic cellular sensitivity to the cytotoxic effects of ionizing radiation (IR). Moreover, a strategy to combine adenovirus-mediated wild-type p53 gene transfer with DNA-damaging treatments, such as IR and chemotherapeutic agents, has also been studied in glioblastoma, lung, colorectal, ovarian, and head-and-neck cancers, and additional cytotoxicity or tumor-suppressing activity has been consistently observed. In prostate cancer cells, the significant cytotoxicity has been previously reported with the induction of recombinant wild-type p53 adenovirus (Ad5CMV-p53). In this study, the interactions between IR and Ad5CMV-p53 gene therapy in two androgen-independent prostate cancer cell lines (DU145 and PC-3) were evaluated. We demonstrated that this combination therapy resulted in remarkable synergistic effects and also assessed its molecular mechanisms. The cell growth inhibition in DU145 (p53-mutated) cells by IR was strongly enhanced by additional Ad5CMV-p53 infection in a viral dose-dependent manner. In DU145 cells, IR alone induced minimal p53 mRNA expression. However, IR combined with Ad5CMV-p53 infection stimulated significant increase in p53 mRNA expression supplemented with Bax and p21 mRNA expressions. In PC-3 (p53-null), IR induced Bax and p21 mRNA expression, while the combination effects were observed in p53, Bax, and p21 mRNA expression. Apoptotic cell deaths were rarely observed after IR alone (DU145: 3%, PC-3: 5%). However, after combination therapy, the proportion of apoptotic cells greatly increased (sevenfold in DU145 cells, and twice in PC-3 cells). G1 cell cycle arrest was observed after Ad5CMV-p53 infection and the combination in both cell lines. In conclusion, Ad5CMV-p53 infection enhances the effect of radiation therapy by efficient induction of apoptosis and cell cycle arrest. This combination therapy could be one of the optimal treatment strategies for radioresistant prostate cancer.

  • Basic research for the development of electroporation-electrode-mounted balloon catheter
    YAMADA Kazunari, SASAKI Ryohei, MORI Takeki, SUGIMOTO Koji
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 1999 - 2001
    Purpose : To develop the effective way to transfer genes to the vessel wall by using the electroporation Materails and methods : 1 : We developed the percutaneously insertable electroporation needle, and performed the reporter gene transfer to the thigh muscles of the rabbits. Basic structure of the percutaneously insertable electroporation needle is composed of two outer needles separated by a distance of 10 mm and the DNA injection needle placed in the halfway of two outer needles. Two outer needles and DNA injection needle can be simultaneously inserted. After the retraction of the outer needles, electroporation needles can be exposed to the target area. Without imaging guidance, two outer needles the DMA needle were inserted to the thigh muscles. Then, after the green fluorescent protein (GFP) was injected, electroporation was performed. Three days later, gene transfer was checked. 2 : Under imaging guidance, the electroporation needles and were inserted to the thigh muscle of the rabbits. Under CT-guidance, two outer needles the DNA needle were inserted to the thigh muscles Then, after the green fluorescent protein (GFP) was injected, electroporation was performed. Three days later, gene transfer was checked. 3 : Percutaneously insertable electroporation balloon catheter models were designed, and evaluated its feasibility for the in vivo use. Also, the balloon catheter was inserted to the femoral artery and renal artery of the rabbits under imaging guidance to evaluate the visibility and the effect to the vessel wall. Results Both with and without imaging guidance, the gene expression was confirmed in the area of the thigh between the two electroporaton needles. Without imaging guidance, it was not possible to detect the precise position of the needle tip. Two types of the electroporation balloon catheter were designed. A) Electroporation wires were attached to the balloon in a parallel way. Wires are compressed to the vessel wall when the balloon is inflated. B) Electroporation needles were expanded from the balloon catheter vertically to the vessel wall. However, at the present time, these designs are difficult to be applied in vivo, and needed the further improvement and evaluation.

■ Industrial Property Rights
  • 放射線治療用スペーサー
    佐々木 良平
    特願2016-181028, 14 Sep. 2017, 特開2018-42855, 22 Mar. 2018, 特表PCT/JP2017/33200, 特許PCT/JP2017/33200, 日本国 (JP) 米国、欧州(ドイツ、スイス、フランス、イギリス、オランダ、イタリア)、中国、韓国
    Patent right

  • 放射線治療剤
    OGINO CHIAKI, TANAKA TSUTOMU, SASAKI RYOHEI, KONDO AKIHIKO
    特願2012-500638, 17 Feb. 2011, 大学長, 特許5649137, 21 Nov. 2014
    Patent right

  • 放射線治療剤(中)
    OGINO CHIAKI, TANAKA TSUTOMU, SASAKI RYOHEI, KONDO AKIHIKO
    201180008541.3, 17 Feb. 2011, 大学長, ZL201180008541.3, 02 Jul. 2014
    Patent right

  • 放射線治療剤
    OGINO CHIAKI, TANAKA TSUTOMU, SASAKI RYOHEI, KONDO AKIHIKO
    13/578836, 17 Feb. 2011, 大学長, 8580312, 12 Nov. 2013
    Patent right

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