Research activity information

• Nov. 2021 International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine, Best Global Perspective Award in the JISAKOS Best Article competition, Younger age and greater preoperative function predict compliance with 2-year follow-up visits after ACL reconstruction: an analysis of the PIVOT multicentre trial

  Jayson Lian, João Victor Novaretti, Neel K Patel, Adam C Popchak, Ryosuke Kuroda, Stefano Zaffagnini, Kristian Samuelsson, Volker Musahl


• Mar. 2019 第24回日本軟骨代謝学会, 第24回日本軟骨代謝学会賞, サイクリンディペンデントキナーゼインヒビター1欠損マウスは炎症の増悪を伴い変形性関節症が進行する

  木原伸介、林申也、橋本慎吾、神崎至幸、高山孝治、松本知之、鎮西伸顕、岩佐賢二郎、羽田勝彦、竹内一裕、西田康太郎、黒田良祐


• Sep. 2018 第44回日本整形外科スポーツ医学会, Outstanding Performance Award, Concomitant lateral meniscus tear in the anterior cruciate ligament injured knee should be repaired to avoid remaining pivot-shift

  Yuichi Hoshino, Nobuaki Miyaji, Yuji Hiroshima, Takahiro Yamashita, Kazuyuki Ibaraki, Daisuke Araki, Noriyuki Kanzaki, Takehiko Matsushita, Ryosuke Kuroda


• Jun. 2017 International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine, JAN GILLQUIST SCIENTIFIC AWARD, Aggravated Rotational Laxity Due to the Concomitant Meniscus Tear in the Anterior Cruciate Ligament-Injured Knees Detected by the Quantitative Measurement of the Pivot-Shift Test

  Yuichi Hoshino, Nobuaki Miyaji, Kazuyuki Ibaraki, Toshikazu Tanaka, Kyohei Nishida, Daisuke Araki, Noriyuki Kanzaki, Takehiko Matsushita, Ryosuke Kuroda


• May 2016 European Society of Sports Traumatology, Knee Surgery & Arthroscopy （ESSKA), KSSTA Best Reviewer Award 2016

  Kuroda Ryosuke

  International society


• Mar. 2015 日本軟骨代謝学会, 第20回日本軟骨代謝学会賞, マウスにおける軟骨内Sirt1欠損は機械的ストレスや加齢によって変形性関節症を促進する

  松崎時夫, 松下雄彦, 高山孝治, 髙山孝治, 松本知之, Nishida Kotaro, Kuroda Ryosuke, Kurosaka Masahiro

  Japan society


• May 2013 International Society of Arthroscopy,Knee Surgery and Orthopaedic Sports Medicine, patellofemoral research excellence award, A Simulation of the Optimal Femoral Insertion Site in Medial Patellofemoral Ligament Reconstruction

  ShinyaOka, TakehikoMatsushita, SeijiKubo, TomoyukiMatsumoto, YuichiroNishizawa, TokioMatsuzaki, KantoNagai, Kurosaka Masahiro, Kuroda Ryosuke

  International society


• May 2012 Trauma Asia Pacific Scientific Congress, Best Poster Award, Efficient Derivation of Osteoprogenitor Cells from Induced Pluripotent Stem Cells for Bone Regeneration

  Lee Sangyang, Niikura Takahiro, Nishida Kotaro, Kuroda Ryosuke, Kurosaka Masahiro

  International society


• Aug. 2011 Tissue Engineering and Regenerative Medicine International Society, Best Poster Award Young Investigator SYIS-AP First Prize, Local delivery of Ex-vivo Expanded Bone Marrow CD34 Positive Progenitor cells Using Bioscaffold for Treatment of Unhealing Bone Fracture

  Kurosaka Masahiro, Kuroda Ryosuke


• Apr. 2011 第116回中部日本整形外科災害外科学会・学術集会, 学会奨励賞, 前十字靱帯不全膝における膝最大伸展位での脛骨前方偏位の検討

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro


• Oct. 2010 The Orthopaedic Research Societies, ・New Investigator Recognition Awards（NIRA）, Granulocyte Colony Stimulating Factor-Mobilized CD34-Positive Progenitor Cell Transplantation for Nonunion of Bone Fractures

  Kuroda Ryosuke


• Oct. 2010 The Orthopaedic Research Societies, New Investigator Recognition Awards (NIRA), Autophagy modulates osteoarthritis-related gene expressions in human chondrocytes

  Kuroda Ryosuke, Kubo Seiji


• Feb. 2010 The Hong Kong Jockey Club Sports Medicine and Health Sciences Centre, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, International Symposium on Ligaments and Tendons-X. Best Poster Award, Neovascularization is an essential factor in medial collateral ligament (MCL) healing

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro


• Oct. 2007 中部日本整形外科災害外科学会, 第１０９回中部日本整形外科災害外科学会会長奨励賞, 鏡視下前十字靱帯再建術において膝屈曲角度は大腿骨骨孔位置の決定にどのように影響するか？

  Kuroda Ryosuke, Kurosaka Masahiro


• Jun. 2006 Combined Congress of JOSKAS(Japanese Orthopaedic Societies of Knee, Arthroscopy and Sports Medicine, Combined Congress of JOSKAS 2006 Best Poster Award, 大腿骨コンポーネント設置後の関節ギャップ（コンポーネントギャップ）が術後屈曲角度に及ぼす影響

  MIZUNO KIYONORI, KURODA RYOSUKE, Kurosaka Masahiro


• Feb. 2005 日本膝関節学会, 第30回日本膝関節学会ポスター賞, 脛骨粗面の位置が膝関節回旋アライメントに及ぼす影響の検討

  KURODA Ryosuke, MIZUNO Kiyonori, MURATSU Hirotsugu, 田中 浩一, 松本 彰生, 八木 正義, 山口 基, YOSHIYA Shinichi, KUROSAKA Masahiko


• Feb. 2005 日本膝関節学会, The best paper of the year, basica, ACL不全膝及びACL再建膝における回旋不安定性の定量的評価－Knee Tester(KT-2000)による前方不安定性評価との比較－

  八木 正義, 岩崎 安伸, NAGAMUNE Kouki, 星野 祐一, 田中 浩一, MIZUNO Kiyonori, KURODA Ryosuke, MURATSU Hirotsugu, YOSHIYA Shinichi, KUROSAKA Masahiko


• Nov. 2004 Orthopaedics, Biomechanics, Sports Rehabilitation, the finalists for the 2005 Young Researchers of Orthopaedics, Biomechanics/Biology, Operative Techniques and Sports (Y-ROBOTS) Award, Noninvasive Electromagnetic Arthrometer for Assessing the Knee Manual Laxity Test

  NAGAMUNE Kouki, NAGAMUNE Kouki, Seiji Kubo, Yuichi Hoshino, Koichi Tanaka, Masayoshi Yagi, MIZUNO Kiyonori, KURODA Ryosuke, Shinich Yoshiya, KUROSAKA Masahiko


• Sep. 2004 The Asia Pacific Orthopaedic Association, 14th Congress of Asia Pacific Orthopaedic Association, Human hemarthrosis-derived cells can differentiate into osteoblasts

  Takahiro Niikura, MIWA Masahiko, Yoshitada Sakai, Sang Yang Lee, KURODA Ryosuke, Takaaki Fujishiro, Seiji Kubo, YOSHIYA Shinichi, KUROSAKA Masahiko


• Jul. 2003 American Orthopaedic Society for Sports Medicine, Aircast Award for Basic Science, The effect of relaxin treatment in skeletal muscle injuries

  Shinighi Negishi, Yong Li, Will Foster, Jim Cummins, KURODA Ryosuke, Freddie Fu, Johnny Huard

• Potential of boron neutron capture therapy (BNCT) for myxofibrosarcoma.

  Takuya Fujimoto, Tooru Andoh, Tamotsu Sudo, Ikuo Fujita, Yoshinori Sakurai, Takushi Takata, Hiroki Tanaka, Teruya Kawamoto, Shunsuke Yahiro, Shotaro Nakamura, Hitomi Hara, Naomasa Fukase, Toshihiro Akisue, Hideki Ichikawa, Ryosuke Kuroda, Minoru Suzuki

  Myxofibrosarcoma, a rare malignant tumor, predominantly affects the extremities of the elderly. Because of its invasive nature amputation is sometimes required, resulting in serious deterioration of quality of life. Therefore, cell lines established from amputated surgical specimens of myxofibrosarcoma in the upper limbs of elderly patients were used to create a myxofibrosarcoma-bearing animal model and to investigate the therapeutic effect of BNCT thereon. The results demonstrated selective destruction of tumor cells, suggesting the anti-tumor efficacy of BNCT on myxofibrosarcoma.

  Mar. 2025, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 217, 111603 - 111603, English, International magazine

  Scientific journal


• SPRR1A is a potential therapeutic target for osteosarcoma: in vitro and in vivo evaluations using generated artificial osteosarcoma cancer stem cell‑like cells.

  Tomohiro Miyamoto, Naomasa Fukase, Teruya Kawamoto, Shuichi Fujiwara, Hitomi Hara, Ryoko Sawada, Yuta Nakamatsu, Yutaka Mifune, Kenichiro Kakutani, Yuichi Hoshino, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Michiyo Koyanagi-Aoi, Takashi Aoi, Toshiyuki Takemori, Shunsuke Yahiro, Ryosuke Kuroda, Toshihiro Akisue

  Cancer stem cells (CSCs) have been implicated as critical mediators in the progression, chemoresistance and metastatic capabilities of diverse malignancies, including osteosarcoma (OS). The authors have succeeded in generating CSC‑like cells (MG‑OKS) from the OS cell line MG‑63 by transducing defined factors. A significant increase in small proline‑rich protein 1A (SPRR1A) expression, a cross‑linked envelope protein in keratinocytes, was observed in MG‑OKS cells. Therefore, SPRR1A could be involved in tumor initiation, growth and poor OS progression. However, its specific role in OS remains unclear. The present study aimed to evaluate the role of SPRR1A in OS both in vitro and in vivo using MG‑OKS cells. Three experimental groups were established: MG‑OKS cells transfected with SPRR1A small interfering (si)RNA (siMG‑OKS), untransfected MG‑OKS cells and MG‑OKS cells transfected with scrambled siRNA (scMG‑OKS) as controls. SPRR1A expression, morphological changes, cell proliferation and migration were assessed in these groups. RNA sequencing was performed to examine the genetic changes caused by SPRR1A suppression. To evaluate tumorigenicity in vivo, cells from each group were subcutaneously transplanted into the backs of nude mice. Tumor volume and Ki‑67 expression were assessed and compared among the three groups at four weeks post‑transplantation. The siMG‑OKS group exhibited altered cell morphology, reduced cell proliferation and decreased migratory abilities in vitro. RNA sequencing revealed suppression of genes involved in cell adhesion in the siMG‑OKS group. Furthermore, the in vivo tumorigenicity of siMG‑OKS was lower than that of the other two experimental groups. These findings suggest that SPRR1A is one of the key cell adhesion‑related molecules involved in OS progression, potentially serving as a therapeutic target for this refractory tumor. However, further research is needed to fully elucidate the mechanisms by which SPRR1A influences OS pathogenesis and to explore its clinical potential.

  Feb. 2025, Oncology reports, 53(2) (2), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Quadriceps strength can improve twelve months after opening wedge high tibial osteotomy and opening wedge distal tibial tubercle osteotomy, particularly after opening wedge high tibial osteotomy.

  Ryo Goto, Takehiko Matsushita, Yuya Ueda, Yohei Shibata, Daisuke Miura, Kumiko Ono, Akihiro Kida, Kyohei Nishida, Kanto Nagai, Noriyuki Kanzaki, Yuichi Hoshino, Yoshitada Sakai, Ryosuke Kuroda

  BACKGROUND: Knee osteoarthritis (KOA) is a globally prevalent condition leading to joint pain and disabilities. Surgical interventions such as opening-wedge high tibial osteotomy (OWHTO) and opening-wedge distal tuberosity osteotomy (OWDTO) aim to alleviate symptoms and delay disease progression. Quadriceps strength, crucial for knee function, may decline postoperatively, affecting patient outcomes. However, little is known about quadriceps strength variation after OWHTO and OWDTO. This study investigated changes in quadriceps strength before and after OWHTO and OWDTO. METHODS: This retrospective study included patients who underwent OWHTO or OWDTO between 2016 and 2022. Quadriceps strength and demographic and surgical data were collected preoperatively and at 6 and 12 months postoperatively. Statistical analyses were performed to compare changes in quadriceps strength over time. RESULTS: Of 120 knees, 52 (OWHTO, 27; OWDTO, 25) were included in this study. Quadriceps strength increased over 12 months post-OWHTO, significantly improving at 12 months compared to the preoperative and 6-month values. In OWDTO, the strength improved but not significantly. CONCLUSIONS: Quadriceps strength improved following OWHTO and OWDTO, with OWHTO showing significant enhancements. Future studies should investigate the relationship between quadriceps strength and functional outcomes and guide rehabilitation strategies for improved postoperative recovery.

  Dec. 2024, The Knee, 51, 258 - 267, English, International magazine

  Scientific journal


• Leveraging AI models for lesion detection in osteonecrosis of the femoral head and T1‐weighted MRI generation from radiographs

  Issei Shinohara, Atsuyuki Inui, Katherine Hwang, Masatoshi Murayama, Yosuke Susuki, Tomohiro Uno, Qi Gao, Mayu Morita, Simon Kwoon‐Ho Chow, Masanori Tsubosaka, Yutaka Mifune, Tomoyuki Matsumoto, Ryosuke Kuroda, Stuart B. Goodman

  Abstract This study emphasizes the importance of early detection of osteonecrosis of the femoral head (ONFH) in young patients on long‐term glucocorticoid therapy, including those with acute lymphoblastic leukemia, lupus, and other diagnoses. While X‐ray and magnetic resonance imaging (MRI) are standard imaging methods for staging ONFH, MRI can be costly and time‐consuming. The research focuses on utilizing artificial intelligence (AI) to enhance the evaluation of radiographic images for ONFH detection. The study involved analyzing X‐ray and MRI from 102 control hips and 104 ONFH‐affected hips at Association Research Circulation Osseous (ARCO) Stage II and IIIa. We employed transfer learning with the YOLOv8 model for object detection, using 80% of the data for training and 20% for validation, then assessed detection accuracy through mean average precision (mAP) and a precision‐recall curve. Additionally, AI generated synthetic MRI (sMRI) from X‐ray images using a Generative Adversarial Network (GAN) and evaluated their similarity to original MRI. Results showed that the mAP for ONFH detection was 0.923 for the YOLOv8n model and 0.951 for YOLOv8x. The GAN‐generated sMRI exhibited lower image quality compared with originals but maintained potential for lesion assessment. Intrarater reliability among evaluators was high. The findings indicate that AI techniques, particularly YOLOv8 for object detection and GAN for image generation, can effectively assist in ONFH screening, despite some limitations in the generated MRI quality.

  Wiley, Nov. 2024, Journal of Orthopaedic Research

  Scientific journal


• Transcutaneous CO2 application combined with low-intensity pulsed ultrasound accelerates bone fracture healing in rats.

  Kenichi Sawauchi, Tomoaki Fukui, Keisuke Oe, Takahiro Oda, Ryo Yoshikawa, Kyohei Takase, Shota Inoue, Ryota Nishida, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Low-intensity pulsed ultrasound (LIPUS) is a non-invasive therapy that accelerates fracture healing. As a new treatment method for fracture, we recently reported that the transcutaneous application of CO2 accelerated fracture healing in association with promoting angiogenesis, blood flow, and endochondral ossification. We hypothesized that transcutaneous CO2 application, combined with LIPUS, would promote bone fracture healing more than the single treatment with either of them. METHODS: Femoral shaft fractures were produced in 12-week-old rats. Animals were randomly divided into four groups: the combination of CO2 and LIPUS, CO2, LIPUS, and control groups. As the transcutaneous CO2 application, the limb was sealed in a CO2-filled bag after applying hydrogel that promotes CO2 absorption. Transcutaneous CO2 application and LIPUS irradiation were performed for 20 min/day, 5 days/week. At weeks 1, 2, 3, and 4 after the fractures, we assessed the fracture healing process using radiography, histology, immunohistochemistry, real-time PCR, and biomechanical assessment. RESULTS: The fracture healing score using radiographs in the combination group was significantly higher than that in the control group at all time points and those in both the LIPUS and CO2 groups at weeks 1, 2, and 4. The degree of bone fracture healing in the histological assessment was significantly higher in the combination group than that in the control group at weeks 2, 3, and 4. In the immunohistochemical assessment, the vascular densities of CD31- and endomucin-positive microvessels in the combination group were significantly higher than those in the control and LIPUS groups at week 2. In the gene expression assessment, significant upregulation of runt-related transcription factor 2 (Runx2) and vascular endothelial growth factor (VEGF) was detected in the combination group compared to the LIPUS and CO2 monotherapy groups. In the biomechanical assessment, the ultimate stress was significantly higher in the combination group than in the LIPUS and CO2 groups. CONCLUSION: The combination therapy of transcutaneous CO2 application and LIPUS had a superior effect in promoting fracture healing through the promotion of angiogenesis and osteoblast differentiation compared to monotherapy.

  Oct. 2024, BMC musculoskeletal disorders, 25(1) (1), 863 - 863, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• がんロコモ対策の現状と課題 四肢骨転移に対する治療の現状と課題

  原 仁美, 深瀬 直政, 澤田 良子, 藤原 周一, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 68 - 68, Japanese


• 整形外科における女性医師キャリア形成の現状と課題 自身のキャリア形成の現状と課題 1度手術を手放した私が再び手術を学ぶチャンスをつかむまで

  澤田 良子, 藤原 周一, 深瀬 直政, 原 仁美, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 92 - 92, Japanese


• 膝関節内に巨大腫瘤を形成し腱滑膜巨細胞腫との鑑別を要した滑膜軟骨腫症の一例

  今井 貞之, 深瀬 直政, 原 仁美, 藤原 周一, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 269 - 269, Japanese


• 肘部管症候群を合併した右肘滑膜軟骨腫症の一例

  藤原 周一, 原 仁美, 深瀬 直政, 澤田 良子, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 269 - 269, Japanese


• 骨肉腫細胞におけるSPRR1Aの機能の探索 新規開発骨肉腫がん幹細胞様細胞を用いた検討

  宮本 智弘, 藤原 周一, 原 仁美, 深瀬 直政, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 320 - 320, Japanese


• Ewing肉腫におけるslow-cycling-cellsの特性の探索 次世代シーケンス解析を用いた検討

  中松 裕太, 深瀬 直政, 原 仁美, 藤原 周一, 黒田 良祐, 秋末 敏宏

  (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 320 - 320, Japanese


• 人工足関節置換術後患者における足趾把持力と歩行能力の関係について

  古谷 彰隆, 神崎 至幸, 上田 雄也, 松野 凌馬, 岡田 亮, 蒲地 正宗, 大月 悠平, 山本 哲也, 黒田 良祐, 秋末 敏宏

  (一社)日本足の外科学会, Oct. 2024, 日本足の外科学会雑誌, 45(2) (2), S270 - S270, Japanese


• Human uncultured adipose-derived stromal vascular fraction shows therapeutic potential against osteoarthritis in immunodeficient rats via direct effects of transplanted M2 macrophages.

  Yuma Onoi, Tomoyuki Matsumoto, Kensuke Anjiki, Shinya Hayashi, Naoki Nakano, Yuichi Kuroda, Masanori Tsubosaka, Tomoyuki Kamenaga, Kemmei Ikuta, Shotaro Tachibana, Yoshihito Suda, Kensuke Wada, Takuma Maeda, Akira Saitoh, Takafumi Hiranaka, Satoshi Sobajima, Hideki Iwaguro, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: The uncultured adipose-derived stromal vascular fraction (SVF), consisting of adipose-derived stromal cells (ADSCs), M2 macrophages (M2Φ) and others, has shown therapeutic potential against osteoarthritis (OA), however, the mechanisms underlying its therapeutic effects remain unclear. Therefore, this study investigated the effects of the SVF on OA in a human-immunodeficient rat xenotransplantation model. METHODS: OA model was induced in the knees of female immunodeficient rats by destabilization of the medial meniscus. Immediately after the surgery, human SVF (1 × 105), ADSCs (1 × 104), or phosphate buffered saline as a control group were transplanted into the knees. At 4 and 8 weeks postoperatively, OA progression and synovitis were analyzed by macroscopic and histological analyses, and the expression of collagen II, SOX9, MMP-13, ADAMTS-5, F4/80, CD86 (M1), CD163 (M2), and human nuclear antigen (hNA) were evaluated immunohistochemically. In vitro, flow cytometry was performed to collect CD163-positive cells as M2Φ from the SVF. Chondrocyte pellets (1 × 105) were co-cultured with SVF (1 × 105), M2Φ (1 × 104), and ADSCs (1 × 104) or alone as a control group, and the pellet size was compared. TGF-β, IL-10 and MMP-13 concentrations in the medium were evaluated using enzyme-linked immunosorbent assay. RESULTS: In comparison with the control and ADSC groups, the SVF group showed significantly slower OA progression and less synovitis with higher expression of collagen II and SOX9, lower expression of MMP-13 and ADAMTS-5, and lower F4/80 and M1/M2 ratio in the synovium. Only the SVF group showed partial expression of hNA-, CD163-, and F4/80-positive cells in the rat synovium. In vitro, the SVF, M2Φ, ADSC and control groups, in that order, showed larger pellet sizes, higher TGF-β and IL-10, and lower MMP-13 concentrations. CONCLUSIONS: The M2Φ in the transplanted SVF directly affected recipient tissue, enhancing the secretion of growth factors and chondrocyte-protecting cytokines, and partially improving chondrocytes and joint homeostasis. These findings indicate that the SVF is as an effective option for regenerative therapy for OA, with mechanisms different from those of ADSCs.

  Sep. 2024, Stem cell research & therapy, 15(1) (1), 325 - 325, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 網羅的遺伝子解析を用いたEwing肉腫におけるslow-cycling-cellsの特性の探索

  中松 裕太, 深瀬 直政, 原 仁美, 澤田 良子, 藤原 周一, 宮本 智弘, 八尋 俊輔, 青井 三千代, 青井 貴之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Sep. 2024, 日本整形外科学会雑誌, 98(8) (8), S1964 - S1964, Japanese


• 骨肉腫細胞におけるSPRR1Aの機能の探索 新規開発骨肉腫がん幹細胞様細胞を用いた検討

  宮本 智弘, 藤原 周一, 原 仁美, 深瀬 直政, 澤田 良子, 中松 裕太, 青井 貴之, 小柳 三千代, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Sep. 2024, 日本整形外科学会雑誌, 98(8) (8), S1967 - S1967, Japanese


• The medullary cavity morphology of the proximal femur influences the fixation pattern of the rectangular tapered short stem in total hip arthroplasty.

  Yuma Onoi, Shinya Hayashi, Takaaki Fujishiro, Yuichi Kuroda, Naoki Nakano, Takafumi Hiranaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  INTRODUCTION: This study aimed to evaluate differences in the pattern of fixation with a rectangular tapered short stem (Fitmore stem) due to proximal femoral medullary cavity morphology based on periprosthetic bone mineral density (BMD) and radiological findings. MATERIALS AND METHODS: We analyzed 105 consecutive patients (Dorr type A, 18; Dorr type B, 66; Dorr type C, 21) who underwent total hip arthroplasty using a Fitmore stem. Periprosthetic BMD was measured using dual-energy X-ray absorptiometry from 1 to 24 months postoperatively and radiological analysis was performed. Clinical outcomes were evaluated using the Harris hip score (HHS) and the University of California Los Angeles (UCLA) activity score preoperatively and 24 months postoperatively. RESULTS: At 24 months postoperatively, Dorr type C had significantly decreased BMD changes in Gruen zones 2, 6, and 7 compared to Dorr types A and B, and conversely, significantly increased BMD changes in zone 4 (p < 0.05). Dorr type C had significantly greater subsidence than the other types (p < 0.01) and significantly higher cortical hypertrophy in zone 3 (p < 0.01). Stress shielding was not significantly different between Dorr types. The preoperative and postoperative HHS and UCLA activity scores showed no significant differences between the Dorr types. CONCLUSIONS: In Dorr type C, BMD significantly decreased in the proximal femur with a rectangular tapered short stem, suggesting that the stem was fixed at the distal part. Careful observation of this prosthesis over time is needed in patients with Dorr type C.

  Aug. 2024, Archives of orthopaedic and trauma surgery, 144(8) (8), 3857 - 3864, English, International magazine

  Scientific journal


• 肉腫治療の次の一手 癌の骨浸潤に対してホウ素中性子捕捉療法(BNCT)は可能か

  藤本 卓也, 神谷 伸彦, 南 裕介, 櫻井 良憲, 圓尾 明弘, 八尋 俊輔, 藤田 郁夫, 秋末 敏宏, 黒田 良祐, 鈴木 実

  (公社)日本整形外科学会, Jun. 2024, 日本整形外科学会雑誌, 98(6) (6), S1487 - S1487, Japanese


• Compress型インプラントによる腫瘍用人工関節置換術例の検討

  深瀬 直政, 原 仁美, 澤田 良子, 藤原 周一, 秋末 敏宏, 黒田 良祐

  (公社)日本整形外科学会, Jun. 2024, 日本整形外科学会雑誌, 98(6) (6), S1506 - S1506, Japanese


• Ewing肉腫におけるslow-cycling-cellsの特性の探索

  中松 裕太, 深瀬 直政, 原 仁美, 澤田 良子, 藤原 周一, 宮本 智弘, 八尋 俊輔, 青井 三千代, 青井 貴之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2024, 日本整形外科学会雑誌, 98(6) (6), S1527 - S1527, Japanese


• 骨肉腫細胞におけるSPRR1Aの機能の探索 新規開発骨肉腫がん幹細胞様細胞を用いた検討

  宮本 智弘, 藤原 周一, 原 仁美, 深瀬 直政, 澤田 良子, 中松 裕太, 青井 貴之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2024, 日本整形外科学会雑誌, 98(6) (6), S1528 - S1528, Japanese


• 転移性骨腫瘍に対するデノスマブ長期投与中止後の調査

  原 仁美, 深瀬 直政, 澤田 良子, 藤原 周一, 宮本 智弘, 中松 裕太, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2024, 日本整形外科学会雑誌, 98(6) (6), S1599 - S1599, Japanese


• 術前に陽子線を照射した粘液型脂肪肉腫の2例

  藤原 周一, 出水 祐介, 原 仁美, 深瀬 直政, 澤田 良子, 宮本 智弘, 中松 裕太, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2024, 日本整形外科学会雑誌, 98(6) (6), S1674 - S1674, Japanese


• Morphological analysis of the distal femur as a surgical reference in biplane distal femoral osteotomy.

  Shohei Sano, Takehiko Matsushita, Naosuke Nagata, Takeo Tokura, Koji Nukuto, Yuta Nakanishi, Kyohei Nishida, Kanto Nagai, Noriyuki Kanzaki, Yuichi Hoshino, Tomoyuki Matsumoto, Ryosuke Kuroda

  Distal femoral osteotomy (DFO) is performed alone or with high tibial osteotomy (HTO) for patients with osteoarthritis and distal femur deformities. DFO is technically demanding, particularly when creating an anterior flange. Herein, we examined the morphological characteristics of the distal femur based on the cortical shape as a surgical reference for biplanar DFO. Computed tomography images of 50 valgus and 50 varus knees of patients who underwent biplanar DFO or total knee arthroplasty were analyzed. Axial slices at the initial level of the transverse osteotomy in the DFO and slices 10 mm proximal and 10 mm distal to that level were selected. The medial and lateral cortical angles and heights (MCLA, LCLA, MCH, and LCH) were measured on axial slices. Statistical comparisons were performed between the medial and lateral cortices and valgus and varus knees. MCLA and MCH were significantly smaller and lower, respectively, than LCLA and LCH (P < 0.01). The MCLA and MCH of varus knees were significantly smaller and lower, respectively, than those of valgus knees (P < 0.01). Surgeons should carefully observe morphological differences in the distal femur cortex, distinguishing between medial and lateral knees and varus and valgus knees during the creation of the anterior flange in the DFO.

  Springer Science and Business Media LLC, May 2024, Scientific reports, 14(1) (1), 12130 - 12130, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Variations in knee cartilage thickness: Fully automatic three-dimensional analysis of MRIs from five manufacturers.

  Hisako Katano, Kanto Nagai, Haruka Kaneko, Eiji Sasaki, Naofumi Hashiguchi, Ryosuke Kuroda, Muneaki Ishijima, Yasuyuki Ishibashi, Nobuo Adachi, Makoto Tomita, Jun Masumoto, Ichiro Sekiya

  BACKGROUND: Measurements of knee cartilage thickness derived from MR images are attractive biomarkers for osteoarthritis research. Although some cross-sectional multivendor studies exist, none have employed fully automatic three-dimensional MRI analysis. Our objective was to evaluate the variations in knee cartilage thickness measurements obtained using automated methods and MRI instruments from five different vendors. METHODS: The subjects were 10 healthy volunteers aged 22-60 years. MRI models with 3 Tesla strength from five different companies were used. Cartilage thickness was quantified fully automatically for seven regions. We hypothesized that "the MRI model influences cartilage thickness measurements." Inter-measurement error, defined as the absolute difference between the targeted and median thicknesses determined by the five MRI models, was analyzed using histograms. The factors generating the largest inter-measurement error were also examined. RESULTS: No exceptional trends attributable to a specific instrument model were observed, and the p-value from the Kruskal-Wallis test exceeded 0.05 in all seven regions. Therefore, the study hypothesis was rejected. Of the 350 measurements, the inter-measurement error was ≤0.05 mm in 53 %, ≤0.10 mm in 75 %, and ≤0.20 mm in 95 %. Analysis of the medial tibial cartilage, which had the largest inter-measurement error, revealed mis-extraction of synovial fluid as cartilage. CONCLUSIONS: The choice of MRI model did not influence cartilage thickness measurements. Overall, 95 % of the inter-measurement errors were within 0.20 mm. The greatest error resulted from mis-extracting synovial fluid as cartilage.

  May 2024, European journal of radiology, 176, 111528 - 111528, English, International magazine

  Scientific journal


• The assessment of canal flare index and proximal femoral bone density can improve stem selection for peri-prosthetic bone maintenance after total hip arthroplasty.

  Shinya Hayashi, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Masanori Tsubosaka, Shotaro Tachibana, Ryosuke Kuroda

  INTRODUCTION: Bone maintenance after total hip arthroplasty (THA) is important for implant success. This study aimed to investigate the relationship between patient characteristics and periprosthetic bone maintenance after THA for better implant selection. MATERIALS AND METHODS: This retrospective cohort study enrolled 112 consecutive patients who underwent THA using full hydroxyapatite (HA) compaction with short (n = 55) or short-tapered wedge (n = 61) stems. Periprosthetic bone mineral density (BMD) was compared between the two groups after propensity score matching, and the relationship between periprosthetic BMD changes and patient background was analyzed. RESULTS: Both groups showed similar periprosthetic BMD changes after adjusting for patient background using propensity score matching. Canal flare index > 3.7 in patients that underwent THA using tapered-wedge stem (odds ratio (OR), 3.2; 95% confidence interval (CI), 1.3-7.9, p = 0.013) and baseline zone 1 BMD > 0.65 in patients that received with short HA compaction stems (OR, 430.0; 95% CI 1.3-1420, p = 0.040) were associated with proximal periprosthetic bone maintenance after THA. CONCLUSION: Considering their predictive value, canal flare index and zone 1 BMD assessment might be useful strategies for implant selection during THA.

  May 2024, Archives of orthopaedic and trauma surgery, English, International magazine

  Scientific journal


• Estimation of Shoulder Joint Rotation Angle Using Tablet Device and Pose Estimation Artificial Intelligence Model.

  Shunsaku Takigami, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Kohei Yamaura, Tatsuo Kato, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Yutaka Ehara, Ryosuke Kuroda

  Traditionally, angle measurements have been performed using a goniometer, but the complex motion of shoulder movement has made these measurements intricate. The angle of rotation of the shoulder is particularly difficult to measure from an upright position because of the complicated base and moving axes. In this study, we attempted to estimate the shoulder joint internal/external rotation angle using the combination of pose estimation artificial intelligence (AI) and a machine learning model. Videos of the right shoulder of 10 healthy volunteers (10 males, mean age 37.7 years, mean height 168.3 cm, mean weight 72.7 kg, mean BMI 25.6) were recorded and processed into 10,608 images. Parameters were created using the coordinates measured from the posture estimation AI, and these were used to train the machine learning model. The measured values from the smartphone's angle device were used as the true values to create a machine learning model. When measuring the parameters at each angle, we compared the performance of the machine learning model using both linear regression and Light GBM. When the pose estimation AI was trained using linear regression, a correlation coefficient of 0.971 was achieved, with a mean absolute error (MAE) of 5.778. When trained with Light GBM, the correlation coefficient was 0.999 and the MAE was 0.945. This method enables the estimation of internal and external rotation angles from a direct-facing position. This approach is considered to be valuable for analyzing motor movements during sports and rehabilitation.

  May 2024, Sensors (Basel, Switzerland), 24(9) (9), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Influence of Distal Reference Point of the Tibial Mechanical Axis on the Ankle and Hindlimb Alignment Change after Total Knee Arthroplasty.

  Kenichi Kikuchi, Naoki Nakano, Kazunari Ishida, Yuichi Kuroda, Shinya Hayashi, Masanori Tsubosaka, Tomoyuki Kamenaga, Takehiko Matsushita, Ryosuke Kuroda, Tomoyuki Matsumoto

  The alignment philosophy in total knee arthroplasty (TKA) has tended to shift from the gold standard of mechanically aligned technique to personalized alignment, such as the kinematically aligned (KA) technique. However, the influences of different surgical techniques on lower limb alignment relative to the ground are not fully investigated. This study investigated the influence of the ankle and hindlimb alignment change after mechanically aligned TKA and KA-TKA. The varus osteoarthritic patients who underwent TKAs were divided into a mechanically aligned TKA group (group M, n = 50) and a KA-TKA group (group K, n = 50). Radiographic parameters (hip-knee-calcaneus [HKC] angle, hip-knee-ankle [HKA] angle, talar tilt angle [TTA], and tibiocalcaneal angle [TCA]) were investigated using full-length standing radiographs. The deviation angle (ΔTA; angle between the tibial mechanical axis [TMA] and the ground tibial mechanical axis [gTMA]) and the change of ΔTA (cΔTA) were also assessed. These parameters were compared between the two groups, along with the correlation between the preoperative HKA angle and other parameters. ΔTA, TTA, and TCA showed no differences between the groups pre- and postoperatively, and no significant changes were observed postoperatively. The preoperative HKA angle showed a significant negative correlation with cΔTA in both groups (group M: r = -0.33, p = 0.02; group K: r = -0.29, p = 0.04) although no correlation was observed the with preoperative TTA and TCA. Despite no change in ΔTA after surgery, the preoperative varus deformity was associated with a change in the deviation between gTMA and TMA after surgery. A severely varus knee may be inappropriate for ground KA-TKA.

  May 2024, The journal of knee surgery, 37(6) (6), 409 - 415, English, International magazine

  Scientific journal


• What effect does preoperative flexion contracture have on the component angles in unicompartmental knee arthroplasty?

  Naoki Nakano, Masanori Tsubosaka, Tomoyuki Kamenaga, Yuichi Kuroda, Kazunari Ishida, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: The indication for unicompartmental knee arthroplasty (UKA) has been extended to cases with some degree of preoperative knee flexion contracture recently. The purpose of this study was to clarify the effect of flexion contracture on component angles. MATERIALS AND METHODS: Thirty-five fixed-bearing UKAs using the spacer block technique with preoperative flexion contracture (Group FC) and 35 UKAs using the same technique without preoperative flexion contracture (Group NC) were included. Using radiographs, the coronal femoral component angle, coronal tibial component angle, sagittal femoral component angle, and sagittal tibial component angle were determined. Also, extension and flexion angles of the knee as well as coronal Hip-Knee-Ankle (HKA) angles in long-leg standing radiographs were measured. The data about the thickness of the selected insert were also collected. The above results were compared between the two groups. RESULTS: The femoral component tended to be placed in a more varus and flexed position in Group FC, while no significant difference was found about the tibial component angles. While there was no significant difference in pre- and postoperative knee flexion angles between the two groups, flexion contracture remained postoperatively in Group FC. Preoperative HKA angle was greater in Group FC while the difference was no longer significant postoperatively. Regarding the thickness of the selected insert, thicker inserts tended to be used in Group FC. CONCLUSIONS: In fixed-bearing UKA with the spacer block technique, the femoral component tended to be placed in a flexed and varus position in the knees with preoperative flexion contracture.

  May 2024, European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 34(4) (4), 2185 - 2191, English, International magazine

  Scientific journal


• Accuracy of portable navigation during THA in patients with severe developmental dysplasia of hip.

  Shinya Hayashi, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Masanori Tsubosaka, Ryosuke Kuroda

  INTRODUCTION: Correct cup placement in total hip arthroplasty (THA) for patients with developmental dysplasia of the hip (DDH) is considerably difficult. This study aimed to analyze the orientation accuracy of cup insertion during THA using a portable navigation system in patients with DDH. MATERIALS AND METHODS: In this retrospective cohort study, we analyzed data from 64 patients who underwent THA using infrared stereo camera-matching portable navigation. Patients underwent THA via the anterolateral approach in the lateral decubitus position. Navigation records for intraoperative cup angles, postoperative cup angles measured on computed tomography (CT) images, and cup angle measurement differences were measured and compared between patients with non-DDH/mild DDH and severe DDH. Furthermore, the predictive factors for outliers of accurate acetabular cup placement were analyzed. RESULTS: The average measurement absolute abduction differences (postoperative CT-navigation record) were 3.9 ± 3.5° (severe DDH) and 3.3 ± 2.6° (non-DDH/ mild DDH), and the anteversion differences were 4.7 ± 3.4° (severe DDH) and 2.3 ± 2.1° (non-DDH/ mild DDH). The anteversion difference was different between the two groups. Multivariate analysis showed that the navigation difference (absolute difference in anteversion between postoperative CT and navigation records of > 5°) was significantly associated with severe DDH (odds ratio [OR]: 3.3; p = 0.049, 95% confidence interval [CI]: 1.0-11.1) and posterior pelvic tilt (OR: 1.1; p = 0.042, 95% CI: 1.0-1.27). CONCLUSIONS: In patients with severe DDH, it is important to pay close attention during THA using portable navigation. However, the average difference was < 5º even in patients with severe DDH, and the accuracy may be acceptable in a clinical setting when the cost is considered.

  May 2024, Archives of orthopaedic and trauma surgery, 144(5) (5), 2429 - 2435, English, International magazine

  Scientific journal


• Estimating the Thumb Rotation Angle by Using a Tablet Device With a Posture Estimation Artificial Intelligence Model.

  Yutaka Ehara, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Kohei Yamaura, Tatsuo Kato, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Shunsaku Takigami, Ryosuke Kuroda

  MediaPipe Hand (MediaPipe) is an artificial intelligence (AI)-based pose estimation library. In this study, MediaPipe was combined with four machine learning (ML) models to estimate the rotation angle of the thumb. Videos of the right hands of 15 healthy volunteers were recorded and processed into 9000 images. The rotation angle of the thumb (defined as angle θ from the palmar plane, which is defined as 0°) was measured using an angle measuring device, expressed in a radian system. Angle θ was then estimated by the ML model by using parameters calculated from the hand coordinates detected by MediaPipe. The linear regression model showed a root mean square error (RMSE) of 12.23, a mean absolute error (MAE) of 9.9, and a correlation coefficient of 0.91. The ElasticNet model showed an RMSE of 12.23, an MAE of 9.95, and a correlation coefficient of 0.91; the support vector machine (SVM) model showed an RMSE of 4.7, an MAE of 2.5, and a correlation coefficient of 0.99. The LightGBM model achieved high values: an RMSE of 4.58, an MAE of 2.62, and a correlation coefficient of 0.99. Based on these findings, we concluded that the thumb rotation angle can be estimated with high accuracy by combining MediaPipe and ML.

  May 2024, Cureus, 16(5) (5), e59657, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Goal Orientation and Desire for Approval are Associated with Sports Injuries among Young Japanese Athletes

  Yukiko Kimotsuki, Issei Ogasawara, Susumu Iwasaki, Kanto Nagai, Kyohei Nishida, Noriyuki Kanzaki, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda, Ryohei Uchida, Yasuhiro Take, Ken Nakata

  Elsevier BV, May 2024, AJPM Focus, 100236 - 100236

  Scientific journal


• 小児脛骨に発症したBCG骨髄炎の1例

  中松 裕太, 原 仁美, 澤田 良子, 山本 暢之, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2024, 中部日本整形外科災害外科学会雑誌, 67(春季学会) (春季学会), 175 - 175, Japanese


• 人工股関節ステム周囲骨折後偽関節の治療経験

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2024, 中部日本整形外科災害外科学会雑誌, 67(春季学会) (春季学会), 88 - 88, Japanese


• 膝関節が露出した膝蓋骨骨折術後感染をCLAPと腓腹筋弁によりサルベージした一例

  藤原 悠, 大江 啓介, 福井 友章, 隈部 洋平, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2024, 中部日本整形外科災害外科学会雑誌, 67(春季学会) (春季学会), 143 - 143, Japanese


• 人工膝関節全置換術後の細菌感染治療経過中に真菌感染をきたし、一期的に再置換術を施行した一例

  菅野 龍彦, 松本 知之, 中野 直樹, 壺坂 正徳, 大江 啓介, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2024, 中部日本整形外科災害外科学会雑誌, 67(春季学会) (春季学会), 169 - 169, Japanese


• 【骨折治療の現在地を知る!】感染・偽関節 偽関節患者に対する自家末梢血CD34陽性細胞移植による骨・血管再生医療について

  大江 啓介, 新倉 隆宏, 福井 友章, 隈部 洋平, 松本 知之, 黒田 良祐

  金原出版(株), Apr. 2024, 整形・災害外科, 67(5) (5), 681 - 687, Japanese


• Re-tear after arthroscopic rotator cuff tear surgery: risk analysis using machine learning.

  Issei Shinohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Tomoya Yoshikawa, Tatsuo Kato, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Yuichi Hoshino, Takehiko Matsushita, Makoto Mitani, Ryosuke Kuroda

  BACKGROUND: Postoperative rotator cuff retear after arthroscopic rotator cuff repair (ARCR) is still a major problem. Various risk factors such as age, gender, and tear size have been reported. Recently, magnetic resonance imaging-based stump classification was reported as an index of rotator cuff fragility. Although stump type 3 is reported to have a high retear rate, there are few reports on the risk of postoperative retear based on this classification. Machine learning (ML), an artificial intelligence technique, allows for more flexible predictive models than conventional statistical methods and has been applied to predict clinical outcomes. In this study, we used ML to predict postoperative retear risk after ARCR. METHODS: The retrospective case-control study included 353 patients who underwent surgical treatment for complete rotator cuff tear using the suture-bridge technique. Patients who initially presented with retears and traumatic tears were excluded. In study participants, after the initial tear repair, rotator cuff retears were diagnosed by magnetic resonance imaging; Sugaya classification types IV and V were defined as re-tears. Age, gender, stump classification, tear size, Goutallier classification, presence of diabetes, and hyperlipidemia were used for ML parameters to predict the risk of retear. Using Python's Scikit-learn as an ML library, five different AI models (logistic regression, random forest, AdaBoost, CatBoost, LightGBM) were trained on the existing data, and the prediction models were applied to the test dataset. The performance of these ML models was measured by the area under the receiver operating characteristic curve. Additionally, key features affecting retear were evaluated. RESULTS: The area under the receiver operating characteristic curve for logistic regression was 0.78, random forest 0.82, AdaBoost 0.78, CatBoost 0.83, and LightGBM 0.87, respectively for each model. LightGBM showed the highest score. The important factors for model prediction were age, stump classification, and tear size. CONCLUSIONS: The ML classifier model predicted retears after ARCR with high accuracy, and the AI model showed that the most important characteristics affecting retears were age and imaging findings, including stump classification. This model may be able to predict postoperative rotator cuff retears based on clinical features.

  Apr. 2024, Journal of shoulder and elbow surgery, 33(4) (4), 815 - 822, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Predicting postoperative coronal alignment after fixed-bearing unicompartmental knee arthroplasty using a new morphological assessment method: the arithmetic hip-knee-ankle angle.

  Naoki Nakano, Masanori Tsubosaka, Tomoyuki Kamenaga, Yuichi Kuroda, Kazunari Ishida, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: Only a few reports have been published so far on factors that predict postoperative coronal alignment after unicompartmental knee arthroplasty (UKA). The purpose of this study is to clarify the relationship between the arithmetic hip-knee-ankle angle (aHKA) and postoperative coronal alignment after medial fixed-bearing UKA. METHODS: One hundred and one consecutive patients (125 knees) who underwent medial fixed-bearing UKA were assessed. Pre- and postoperative coronal HKA angles, lateral distal femoral angle (LDFA), medial proximal tibial angle (MPTA), and the thickness of the tibial and femoral bone cut were measured. aHKA was calculated as 180° - LDFA + MPTA. Correlations between postoperative HKA angle and aHKA, LDFA, and MPTA were investigated by single regression analysis. After the patients were divided into three groups according to the postoperative HKA angle, i.e., HKA angle > 180°, 175° < HKA angle ≤ 180°, and HKA angle ≤ 175°, aHKA, LDFA, MPTA, preoperative HKA angle, and the thickness of the distal femoral as well as tibial bone cut were compared among the three groups. RESULTS: aHKA and MPTA were positively correlated with postoperative HKA angle, while no correlation was found between postoperative HKA angle and LDFA. Among the three groups classified by postoperative HKA angle, significant differences were found in aHKA, MPTA, and preoperative HKA angle, while no significant difference was found in LDFA and the amount of distal femoral and tibial osteotomies. CONCLUSIONS: aHKA was correlated with postoperative HKA angle after medial fixed-bearing UKA, which was probably due to the influence of MPTA.

  Apr. 2024, International orthopaedics, 48(4) (4), 889 - 897, English, International magazine

  Scientific journal


• Setting hinge position distal to the proximal margin of the distal lateral femur reduces the maximum principal strains of the hinge area and risk of hinge fractures.

  Atsuki Tanaka, Takehiko Matsushita, Tatsuya Nakatsuji, Yosuke Katsui, Kanto Nagai, Kyohei Nishida, Toshiji Mukai, Ryosuke Kuroda

  PURPOSE: The optimal hinge position to prevent hinge fractures in medial closing wedge distal femoral osteotomy (MCWDFO) based on the biomechanical background has not yet been well examined. This study aimed to examine the appropriate hinge position in MCWDFO using finite element (FE) analysis to prevent hinge fractures. METHODS: Computer-aided design (CAD) models were created using composite replicate femurs. FE models of the MCWDFO with a 5° wedge were created with three different hinge positions: (A) 5 mm proximal to the proximal margin of the lateral epicondylar region, (B) proximal margin level and (C) 5 mm distal to the proximal margin level. The maximum and minimum principal strains in the cortical bone were calculated for each model. To validate the FE analysis, biomechanical tests were performed using composite replicate femurs with the same hinge position models as those in the FE analysis. RESULTS: In the FE analysis, the maximum principal strains were in the order of Models A > B > C. The highest value of maximum principal strain was observed in the area proximal to the hinge. In the biomechanical test, hinge fractures occurred in the area proximal to the hinge in Models A and B, whereas the gap closed completely without hinge fractures in Model C. Fractures occurred in an area similar to where the highest maximal principal strain was observed in the FE analysis. CONCLUSION: Distal to the proximal margin of the lateral epicondylar region is an appropriate hinge position in MCWDFO to prevent hinge fractures. LEVEL OF EVIDENCE: Level V.

  Apr. 2024, Journal of experimental orthopaedics, 11(2) (2), e12015, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Injuries to both anterolateral ligament and Kaplan fiber of the iliotibial band do not increase preoperative pivot-shift phenomenon in ACL injury.

  Takeo Tokura, Kanto Nagai, Yuichi Hoshino, Shu Watanabe, Noriyuki Kanzaki, Kyohei Nishida, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: To assess the incidence of anterolateral ligament (ALL) and Kaplan fiber of the iliotibial band (KF) injuries in patients with acute anterior cruciate ligament (ACL) injury on magnetic resonance imaging (MRI), and to investigate the association between these injuries and the magnitude of preoperative pivot-shift test. METHOD: One-hundred and five patients with primary ACL injury were retrospectively reviewed. ALL injury and KF injury were assessed by preoperative MRI, and subjects were allocated into four groups: Group A, neither injury; Group B, only ALL injury; Group C, only KF injury; Group D, simultaneous ALL and KF injuries. Before ACL reconstruction, tibial acceleration during the pivot-shift test was measured by an electromagnetic measurement system, and manual grading was recorded according to the International Knee Documentation Committee (IKDC) guideline. RESULTS: In MRI, the ALL was identified in 104 patients (99.1%) and KF in 99 patients (94.3%). ALL and KF injuries were observed in 43 patients (43.9%) and 23 patients (23.5%), respectively. Patient distribution to each group was as follows; Group A: 43 patients (43.9%), Group B: 32 patients (32.7%), Group C: 12 patients (12.2%), Group D: 11 patients (11.2%). No significant differences were observed in tibial acceleration, and manual grading among the four groups. CONCLUSION: Simultaneous injury to both ALL and KF was uncommon, and preoperative pivot-shift phenomenon did not increase even in those patients. The finding suggests that the role of ALL and KF in controlling anterolateral rotatory knee laxity may be less evident in the clinical setting compared to a biomechanical test setting.

  Apr. 2024, Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology, 36, 40 - 44, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Association Between Psychological Readiness to Return to Sports at 3 Months Postoperatively and Risk of Second ACL Injury.

  Yuya Ueda, Takehiko Matsushita, Yohei Shibata, Kohei Takiguchi, Kumiko Ono, Akihiro Kida, Kyohei Nishida, Kanto Nagai, Yuichi Hoshino, Tomoyuki Matsumoto, Yoshitada Sakai, Ryosuke Kuroda

  BACKGROUND: Psychological readiness to return to sports (RTS) has been associated with second anterior cruciate ligament (ACL) injury. However, this relationship is controversial because covariates such as anatomic and knee function characteristics have not been adequately considered. PURPOSE/HYPOTHESIS: To investigate whether psychological readiness in the early postoperative period can predict the occurrence of a second ACL injury within 24 months after primary ACL reconstruction (ACLR) using propensity score analysis. It was hypothesized that patients with high ACL-RSI after injury (ACL-RSI) scores at 3 months postoperatively would have a second ACL injury within the projected postoperative period. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Included were 169 patients who underwent primary ACLR using hamstring tendon autografts between November 2017 and July 2021 and also underwent knee functional assessments at 3 months postoperatively. The ACL-RSI scale was used to assess psychological readiness for RTS. A second ACL injury was defined if ipsilateral or contralateral ACL injury was confirmed by examination within 24 months postoperatively. Based on a previous study showing that 65 was the highest cutoff value for the ACL-RSI score for RTS, we classified patients into 2 groups: those with high ACL-RSI scores (≥65; group H) and those with low ACL-RSI scores (<65; group L). We generated 1-to-1 matched pairs using propensity score analysis and used log-rank testing to compare the rate of second ACL injury between the 2 groups. RESULTS: More patients returned to any sports activities within 12 months in group H than in group L (90% vs 73%; P = .03). A second ACL injury within 24 months postoperatively was identified in 7% of patients (13/169). The rate of second ACL injury was significantly higher in group H than in group L (17.6% vs 3.4%; P = .001). In 43 matched pairs extracted using propensity scoring, the rate of second ACL injury was also higher in group H than in group L (18.6% vs 4.7%; P = .04). CONCLUSION: Patients with a higher ACL-RSI score at 3 months exhibited a significantly higher incidence of second ACL injury within 24 months after primary ACLR.

  Apr. 2024, Orthopaedic journal of sports medicine, 12(4) (4), 23259671241239325 - 23259671241239325, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Treatment of Osteoporosis in Men on Androgen Deprivation Therapy in Japan.

  Hanako Nishimoto, Atsuyuki Inui, Yutaka Mifune, Kohei Yamaura, Yukari Bando, Yasuyoshi Okamura, Takuto Hara, Tomoaki Terakawa, Ryosuke Kuroda

  Background and Objectives: Androgen deprivation therapy (ADT) for prostate cancer has greatly improved treatment outcomes. As patient survival rates have increased, reports of decreased bone density and increased bone fractures as side effects of ADT have emerged. The prevalence of osteoporosis in Japanese men was 4.6%. The purpose of this study was to evaluate the effect of osteoporosis treatment in prostate cancer patients who underwent ADT in Japan. Materials and Methods: The subjects were 33 male patients who had undergone ADT for prostate cancer, who were noted to have decreased bone density. Mean age was 76.2 ± 7.7 years (64-87). Medications included vitamin D in one case, bisphosphonates (BP) in 27 cases, and denosumab in five cases. The evaluation method examined the rate of change in bone mineral density (BMD) before osteoporosis treatment and 1 year after. For comparison, a group without osteoporosis treatment intervention (n = 33) was selected, and matched for prostate cancer treatment and age. The rate of change in trabecular bone score (TBS) was also calculated. Results: The percentage changes in BMD before and 1 year after treatment were as follows: lumbar spine, 7.1 ± 5.8% in the treatment group versus -3.9 ± 4.1% in the no treatment group; femoral neck, 5.5 ± 6.2% in the treatment group versus -0.9 ± 3.9% in the no treatment group; total femur, 6.6 ± 6.4% in the treatment group versus the no treatment group which was -1.7 ± 3.2%. In all cases, there was a clear significant difference (p < 0.01). The percent change in TBS was further calculated in the same manner. There was no significant difference between the two groups: +1.7 ± 3.8% in the treated group versus +0.3 ± 4.1% in the untreated group. Conclusions: Osteoporosis treatment in Japanese patients with prostate cancer on ADT therapy was found to significantly increase BMD compared to the untreated group. BP and denosumab were found to be very effective in increasing BMD.

  Mar. 2024, Medicina (Kaunas, Lithuania), 60(4) (4), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Prediction of postoperative range of motion after mobile-bearing medial unicompartmental knee arthroplasty from the preoperative range of motion and other preoperative factors.

  Kensuke Anjiki, Takafumi Hiranaka, Toshikazu Tanaka, Takaaki Fujishiro, Koji Okamoto, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: Postoperative flexion after unicompartmental knee arthroplasty might be predicted from the preoperative range of motion and other preoperative factors, but this has not been sufficiently investigated. METHODS: Between 2013 and 2017, 198 patients (198 knees) underwent unilateral knee arthroplasty with medial mobile-bearing unicompartmental knee arthroplasty. Range of motion was measured preoperatively and at the time of final follow-up. To investigate the accuracy of the prediction of preoperative to postoperative gain or loss of the flexion angle, we performed receiver operating characteristic analysis. Logistic regression analysis was used to evaluate other predictive factors. RESULTS: Change in flexion angle was significantly strongly and negatively correlated with the preoperative flexion angle (R= -0.688, 95%CI: -0.755, -0.607, P< 0.001). Preoperative flexion angle was suggested to be a significant predictor of gain or loss of the flexion angle with the area under the curve of 0.781; ,the cut-off value calculated using the Youden index was 140°. Logistic regression analysis showed that in addition to the preoperative flexion angle of the operated side, the postoperative flexion range was significantly affected by the patient's height and by the preoperative flexion angle of the contralateral knee. CONCLUSION: If the preoperative flexion angle in Oxford mobile-bearing medial unicompartmental knee arthroplasty is < 140°, the postoperative flexion angle may be improved; if it exceeds 140°, the postoperative flexion angle may worsen. This predictive ability is further improved by consideration of the patient's height and the range of motion on the contralateral side.

  Mar. 2024, The journal of knee surgery, English, International magazine

  Scientific journal


• 新しい骨転移診療ガイドラインにおける整形外科の関わりと意義 骨転移診断ガイドラインから見た骨転移に対する薬物療法

  原 仁美, 深瀬 直政, 澤田 良子, 藤原 周一, 宮本 智弘, 中松 裕太, 秋末 敏宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2024, 日本整形外科学会雑誌, 98(2) (2), S530 - S530, Japanese


• 脊椎転移手術における原発巣悪性度別手術成績比較

  大西 洋輝, 神田 裕太郎, 由留部 崇, 武岡 由樹, 辻本 武尊, 酒井 良忠, 秋末 敏宏, 黒田 良祐, 角谷 賢一朗

  (公社)日本整形外科学会, Mar. 2024, 日本整形外科学会雑誌, 98(3) (3), S1250 - S1250, Japanese


• 30年の経過を経てchronic expanding hematomaを合併し増大した大腿部gossypiboma(ガーゼオーマ)の1例

  石田 雄也, 深瀬 直政, 藤原 周一, 原 仁美, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2024, 中部日本整形外科災害外科学会雑誌, 67(2) (2), 169 - 170, Japanese


• 非定型大腿骨骨折において骨転移に対する骨修飾薬使用歴の有無が治療経過に与える影響

  福井 友章, 大江 啓介, 隈部 洋平, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2024, 日本整形外科学会雑誌, 98(2) (2), S142 - S142, Japanese


• CLAPにおけるゲンタマイシンの薬物動態に関する検討

  松宮 豊, 大江 啓介, 福井 友章, 隈部 洋平, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2024, 日本整形外科学会雑誌, 98(2) (2), S426 - S426, Japanese


• AMED事業で進む運動器再生医療-臨床研究と医師主導治験- 多施設医師主導治験「自家末梢血CD34陽性細胞移植による骨・血管再生」

  黒田 良祐, 松本 知之, 大江 啓介, 福井 友章, 美舩 泰, 新倉 隆宏

  (公社)日本整形外科学会, Mar. 2024, 日本整形外科学会雑誌, 98(3) (3), S1186 - S1186, Japanese


• A case report of thoracoscopic-assisted resection of osteochondroma of second rib

  WADA Yuka

  THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, Mar. 2024, The Central Japan Journal of Orthopaedic Surgery & Traumatology, 67(2) (2), 167 - 168, Japanese


• 新しい骨転移診療ガイドラインにおける整形外科の関わりと意義 骨転移診断ガイドラインから見た骨転移に対する薬物療法

  原 仁美, 深瀬 直政, 澤田 良子, 藤原 周一, 宮本 智弘, 中松 裕太, 秋末 敏宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2024, 日本整形外科学会雑誌, 98(2) (2), S530 - S530, Japanese


• Knee Osteotomy Decreases Joint Inflammation Based on Synovial Histology and Synovial Fluid Analysis.

  Shu Watanabe, Takehiko Matsushita, Kyohei Nishida, Kanto Nagai, Yuichi Hoshino, Tomoyuki Matsumoto, Ryosuke Kuroda

  PURPOSE: To examine the biological changes in the joints of patients with knee osteoarthritis (OA) before and after around-knee osteotomy (AKO), focusing on synovial fluid (SF) and synovial pathological changes. METHODS: Patients who underwent AKO for medial compartment knee OA between 2019 and 2021 were examined. SF and synovium were obtained at the time of AKO and plate removal after bone union (mean, 16.8 months [range: 11-38 months] postoperatively). SF volume and interleukin (IL)-6 concentrations in SF were assayed using enzyme-linked immunosorbent assay. Synovitis was assessed histologically using a semiquantitative scoring system. Macrophage infiltration was assessed by immunohistochemistry using a semiquantitative score for F4/80 expression. The M1/M2 ratio was calculated using percentage of cells positive for CD80 and CD163. The expression of proinflammatory cytokines was assessed by the percentage of IL-1β- and IL-6-positive cells. The number of vascular endothelial growth factor-positive luminal structures was counted to assess angiogenesis. The change in each parameter was compared before and after AKO using the Wilcoxon matched-pairs signed-rank test. RESULTS: Twenty-four knees of 21 patients were included. SF volume and IL-6 concentration significantly decreased postoperatively (12.6 ± 2.1 mL vs 4.2 ± 0.6 mL; P < .0001 and 50.5 ± 8.6 pg/mL vs 20.7 ± 3.8 pg/mL; P = .0001, respectively). A significant reduction in synovitis score (P = .0001), macrophage infiltration (P < .0003), M1/M2 ratio (P < .0007), angiogenesis (P < .0001), and the percentage of IL-1β- and IL-6-positive cells in the intima (P < .008 and P < .002, respectively) was found after AKO. CONCLUSIONS: SF volume and IL-6 concentrations in the SF decreased and inflammatory synovium pathology improved after AKO. In addition to biomechanical changes, the biological environment of the joint can be improved after AKO. LEVEL OF EVIDENCE: Level IV, retrospective therapeutic case series.

  Mar. 2024, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 40(3) (3), 830 - 843, English, International magazine

  Scientific journal


• Clinical Characteristics, Surgical Outcomes, and Risk Factors for Emergency Surgery in Patients With Spinal Metastases: A Prospective Cohort Study.

  Yutaro Kanda, Kenichiro Kakutani, Yoshitada Sakai, Takashi Yurube, Yoshiki Takeoka, Kunihiko Miyazaki, Hiroki Ohnishi, Tomoya Matsuo, Masao Ryu, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Ryosuke Kuroda

  OBJECTIVE: To elucidate the patient characteristics and outcomes of emergency surgery for spinal metastases and identify risk factors for emergency surgery. METHODS: We prospectively analyzed 216 patients with spinal metastases who underwent palliative surgery from 2015 to 2020. The Eastern Cooperative Oncology Group performance status, Barthel index, EuroQol-5 dimension (EQ5D), and neurological function were assessed at surgery and at 1, 3, and 6 months postoperatively. Multivariate analysis was performed to identify risk factors for emergency surgery. RESULTS: In total, 146 patients underwent nonemergency surgery and 70 patients underwent emergency surgery within 48 hours of diagnosis of a surgical indication. After propensity score matching, we compared 61 patients each who underwent nonemergency and emergency surgery. Regardless of matching, the median performance status and the mean Barthel index and EQ5D score showed a tendency toward worse outcomes in the emergency than nonemergency group both preoperatively and 1 month postoperatively, although the surgery greatly improved these values in both groups. The median survival time tended to be shorter in the emergency than nonemergency group. The multivariate analysis showed that lesions located at T3-10 (p = 0.002; odds ratio [OR], 2.92; 95% confidence interval [CI], 1.48-5.75) and Frankel grades A-C (p < 0.001; OR, 4.91; 95% CI, 2.45-9.86) were independent risk factors for emergency surgery. CONCLUSION: Among patients with spinal metastases, preoperative and postoperative subjective health values and postoperative survival are poorer in emergency than nonemergency surgery. Close attention to patients with T3-10 metastases is required to avoid poor outcomes after emergency surgery.

  Mar. 2024, Neurospine, 21(1) (1), 314 - 327, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effects of high antibiotic concentrations applied to continuous local antibiotic perfusion on human bone tissue-derived cells.

  Yuya Yamamoto, Tomoaki Fukui, Kenichi Sawauchi, Ryo Yoshikawa, Kyohei Takase, Yohei Kumabe, Akihiro Maruo, Takahiro Niikura, Ryosuke Kuroda, Keisuke Oe

  AIMS: Continuous local antibiotic perfusion (CLAP) has recently attracted attention as a new drug delivery system for orthopaedic infections. CLAP is a direct continuous infusion of high-concentration gentamicin (1,200 μg/ml) into the bone marrow. As it is a new system, its influence on the bone marrow is unknown. This study aimed to examine the effects of high-concentration antibiotics on human bone tissue-derived cells. METHODS: Cells were isolated from the bone tissue grafts collected from six patients using the Reamer-Irrigator-Aspirator system, and exposed to different gentamicin concentrations. Live cells rate, apoptosis rate, alkaline phosphatase (ALP) activity, expression of osteoblast-related genes, mineralization potential, and restoration of cell viability and ALP activity were examined by in vitro studies. RESULTS: The live cells rate (the ratio of total number of cells in the well plate to the absorbance-measured number of live cells) was significantly decreased at ≥ 500 μg/ml of gentamicin on day 14; apoptosis rate was significantly increased at ≥ 750 μg/ml, and ALP activity was significantly decreased at ≥ 750 μg/ml. Real-time reverse transcription-polymerase chain reaction results showed no significant decrease in the ALP and activating transcription factor 4 transcript levels at ≥ 1,000 μg/ml on day 7. Mineralization potential was significantly decreased at all concentrations. Restoration of cell viability was significantly decreased at 750 and 1,000 μg/ml on day 21 and at 500 μg/ml on day 28, and ALP activity was significantly decreased at 500 μg/ml on day 28. CONCLUSION: Our findings suggest that the exposure concentration and duration of antibiotic administration during CLAP could affect cell functions. However, further in vivo studies are needed to determine the optimal dose in a clinical setting.

  Mar. 2024, Bone & joint research, 13(3) (3), 91 - 100, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Mid- to Long-Term Results of Total Knee Arthroplasty for Charcot Arthropathy of the Knee.

  Yuma Onoi, Tomoyuki Matsumoto, Naoki Nakano, Masanori Tsubosaka, Tomoyuki Kamenaga, Yuichi Kuroda, Kazunari Ishida, Shinya Hayashi, Ryosuke Kuroda

  BACKGROUND: Total knee arthroplasty (TKA) for Charcot arthropathy of the knee is considered controversial because of its higher complication rate compared with that of TKA for osteoarthritis. In this study, we investigated the clinical outcomes, survival rates, and complications of primary TKA for Charcot arthropathy. METHODS: We conducted a retrospective analysis of nine patients (12 knees) with Charcot arthropathy who underwent TKA. The mean age of the patients was 63.9 ± 9.4 years (range, 52-83 years). The most frequent causative disease was diabetes mellitus (three patients). Patients' clinical outcomes, including the 2011 Knee Society Score and the range of motion, were compared between preoperative and the most recent postoperative data. The 5- and 10-year survival rates for aseptic revision, revision due to infection, and complications were examined. The mean follow-up period was 7.3 ± 3.9 years (range, 3-14 years). RESULTS: The 2011 Knee Society Score and the knee flexion angle significantly improved after TKA surgery (P < 0.05). The 5-year survival rates for aseptic revision, revision due to infection, and complications were 100%, 91.7%, and 83.3%, respectively; the 10-year survival rates for these parameters were the same. One patient underwent revision for insert replacement due to periprosthetic infection, and the other patient had varus/valgus instability due to soft tissue loosening. CONCLUSIONS: The mid- to long-term results of TKA for Charcot arthropathy were generally favorable. Our findings indicate that TKA may be a viable treatment option for Charcot arthropathy.

  Mar. 2024, Indian journal of orthopaedics, 58(3) (3), 308 - 315, English, International magazine

  Scientific journal


• LIGHT regulated gene expression in rheumatoid synovial fibroblasts.

  Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Kenichi Kikuchi, Yoshinori Takashima, Tomoyuki Matsumoto, Ryosuke Kuroda

  BACKGROUND: Synovial hyperplasia caused by rheumatoid arthritis (RA), an autoimmune inflammatory disease, leads to the destruction of the articular cartilage and bone. A member of the tumor necrosis factor superfamily, Lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells (LIGHT) has been shown to correlate with the pathogenesis of RA. METHODS: We used cDNA microarray analysis to compare the expression of genes in rheumatoid fibroblast-like synoviocytes with and without LIGHT stimulation. RESULTS: Significant changes in gene expression (P-values < 0.05 and fold change ≥ 2.0) were associated mainly with biological function categories of glycoprotein, glycosylation site as N-linked, plasma membrane part, integral to plasma membrane, intrinsic to plasma membrane, signal, plasma membrane, signal peptide, alternative splicing, and topological domain as extracellular. CONCLUSIONS: Our results indicate that LIGHT may regulate the expression in RA-FLS of genes which are important in the differentiation of several cell types and in cellular functions.

  Feb. 2024, Molecular biology reports, 51(1) (1), 356 - 356, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Lateral Collateral Ligament Reconstruction Using the Triceps Brachii Fascia for Posterolateral Rotatory Instability in Cubitus Varus: A Report of Two Cases.

  Tatsuya Ito, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Ryosuke Kuroda

  A combination of osteotomy and ligament reconstruction is recommended for posterolateral rotatory instability (PLRI) with large cubitus varus deformities. There is a lack of reports regarding ligament donor selection for ligament reconstruction of PLRI with cubitus varus. Two cases of PLRI with cubitus varus have been described. In case one, a 40-year-old woman presented with left elbow pain. She had a cubitus varus deformity, resulting from a childhood elbow fracture. Radiographs showed an 18-degree cubitus varus deformity. A lateral closing wedge osteotomy and double plate osteosynthesis were performed. The lateral collateral ligament (LCL) was reconstructed with autologous triceps fascia. Postoperative radiographs confirmed correction with 10 degrees of the carrying angle (CA). Bone union at the osteotomy site occurred six months later with excellent results. In case two, a 45-year-old man presented an arm with persistent right elbow instability with cubitus varus deformity. This was due to a childhood supracondylar fracture of the right humerus. Radiographs showed a cubitus varus deformity of 25 degrees on the right. The surgical procedure included a lateral wedge osteotomy, double plate fixation, and LCL reconstruction with autologous triceps fascia. Postoperative radiographs confirmed a corrected CA of 5 degrees. Bone union was achieved at the six-month follow-up with satisfactory results. The use of triceps fascia for LCL reconstruction for PLRI due to cubitus varus would provide a minimally invasive and reasonable treatment option.

  Feb. 2024, Cureus, 16(2) (2), e54530, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Varus placement of the tibial component reduces the potential risk of fracture with adequate bony coverage in the Oxford unicompartmental knee arthroplasty.

  Tomoyuki Kamenaga, Takafumi Hiranaka, Yoshihito Suda, Takaaki Fujishiro, Koji Okamoto, Ryosuke Kuroda, Tomoyuki Matsumoto

  A short keel-cortex distance (KCD), especially to the posterior cortex, is a potential risk factor for tibial plateau fracture after Oxford mobile-bearing unicompartmental knee arthroplasty (OUKA). This study aimed to evaluate the effect of tibial component alignment in the coronal plane and tibial proximal morphology on the KCD. Included in this study were 51 patients scheduled for primary Oxford medial unicompartmental knee arthroplasty (UKA). The anterior and posterior KCD were preoperatively assessed using 3D simulation software with the component set perpendicular to the tibial mechanical axis (neutral), 3° valgus, 3° varus, and 6° varus, relative to neutral alignment. We evaluated the existence of overhanging medial tibial condyle where the medial eminence line, the line including the medial tibial eminence parallel to the tibial axis, passes outside of the tibial shaft. In all component alignments, patients with a medial overhanging condyle had significantly shorter posterior KCD than those without. In patients with a medial overhanging condyle, the posterior KCD significantly increased when the tibial component was placed in 3° varus (4.6 ± 1.5 mm, P = 0.003 vs neutral, P < 0.001 vs 3° valgus) and 6° varus (5.0 ± 1.4 mm, P < 0.001 vs neutral, P < 0.001 vs 3° valgus) compared with in neutral (3.5 ± 1.9 mm) or 3° valgus (2.8 ± 1.8 mm). In OUKA, varus implantation increased the KCD. This could potentially decrease the risk of fracture, even in knees with the overhanging medial condyle. Conversely, valgus implantation of the tibial component shortened the KCD, and should therefore be avoided.

  Jan. 2024, Scientific reports, 14(1) (1), 1274 - 1274, English, International magazine

  Scientific journal


• The severity of preoperative varus deformity affects the feasibility of correcting lower limb alignment with medial unicompartmental knee arthroplasty.

  Naoki Nakano, Yuichi Kuroda, Toshihisa Maeda, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Yuichi Hoshino, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: The relationship between the severity of preoperative varus deformity and the amount of its correction in unicompartmental knee arthroplasty (UKA) as well as the thickness of the insert has not been well known. METHODS: One hundred and three patients who underwent medial fixed-bearing UKA with the use of the spacer block method were assessed. After the component gap in extension was measured using a UKA tensor, the pre-osteotomy gap was calculated from the thickness of the bone cuts. The relationship between the preoperative hip-knee-ankle (HKA) angle as well as the pre-osteotomy gap and the amount of change in HKA angle were analysed. Also, preoperative HKA angle and the thickness of the bone cuts were compared among groups by the insert thickness. RESULTS: The mean preoperative HKA angle was 7.7 ± 3.1° varus. Patients with more varus deformity and those with a wider pre-osteotomy gap showed a more valgus change in HKA angle. As for the thickness of the insert, the preoperative HKA angle of the patients with the thinnest insert was significantly smaller (less varus) than that of those with the thicker insert while no statistically significant difference was found among the insert groups regarding the amount of the bone cuts. CONCLUSIONS: The severity of the preoperative varus deformity as well as the intraoperative pre-osteotomy gap related to the amount of change in HKA angle. As thick inserts tended to be used in severe varus knees, the tibial bone cut can be reduced in such cases.

  Jan. 2024, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 29(1) (1), 183 - 187, English, Domestic magazine

  Scientific journal


• Krüppel-like factor 15 deficiency exacerbates osteoarthritis through reduced expression of peroxisome proliferator-activated receptor gamma signaling in mice.

  Kemmei Ikuta, Shinya Hayashi, Kenichi Kikuchi, Masahiro Fujita, Kensuke Anjiki, Yuma Onoi, Shotaro Tachibana, Yoshihito Suda, Kensuke Wada, Yuichi Kuroda, Naoki Nakano, Toshihisa Maeda, Tomoyuki Matsumoto, Tetsuya Hosooka, Wataru Ogawa, Ryosuke Kuroda

  OBJECTIVE: Krüppel-like zinc finger transcription factors (KLFs) play diverse roles in mammalian cell differentiation and development. In this study, we investigated the function of KLF15 in the progression of osteoarthritis (OA). METHODS: 0Destabilization of the medial meniscus (DMM) surgery was performed in 10-week-old male wild-type control (WT) mice and cartilage-specific KLF15 knockout (KO) mice. Histological analysis, immunohistochemistry, and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling staining were performed. Morphological changes were measured using microcomputed tomography. Six mice from each group were analyzed (total number of mice analyzed: 60). In vitro, immunofluorescence, quantitative reverse transcription-polymerase chain reaction, and western blot analyses were performed. RESULTS: KLF15 KO DMM mice exhibited significant cartilage degradation compared to WT mice. According to the Osteoarthritis Research Society International cartilage OA-histopathology scoring system, the mean sum score in KLF15 KO mice was significantly higher than that in WT mice at 8 weeks after surgery. Immunohistochemistry results revealed KLF15 KO mice exhibited reduced peroxisome proliferator-activated receptor gamma (PPARγ) expression, increased pIKKα/β, a disintegrin-like and metalloproteinase with thrombospondin motifs (ADAMTS) 5, and Matrix metalloproteinases (MMP13) expression, and reduced Forkhead box O (FOXO1) and Light chain 3B (LC3B) expression. Inhibition of PPARγ phosphorylation accelerated the effects of interleukin (IL) 1β-treatment in both KLF15 KO and WT chondrocytes, and activation of PPARγ expression canceled the IL1β-induced catabolic effects. CONCLUSION: Our results indicated that the OA phenotype of KLF15 KO DMM mice was influenced by reduced PPARγ expression, including enhanced pIKKα/β, ADAMTS5, and MMP13 expression, reduced autophagy, and increased apoptosis. KLF15 regulation may constitute a possible therapeutic strategy for the treating OA.

  Jan. 2024, Osteoarthritis and cartilage, 32(1) (1), 28 - 40, English, International magazine

  Scientific journal


• Clinical outcomes of arthroscopic lateral ligament repair using a knotless anchor for chronic lateral ankle instability.

  Masashi Shimabukuro, Yuichi Hoshino, Noriyuki Kanzaki, Kiminari Kataoka, Tetsuya Yamamoto, Koji Nukuto, Kyohei Nishida, Kanto Nagai, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND/OBJECTIVE: Arthroscopic lateral ligament repair (ALLR) for chronic lateral ankle instability (CLAI) has been improving with technical innovations. However, there is a lack of information regarding mid- and/or long-term clinical outcomes after the introduction of ALLR. This study aimed to report mid-term clinical outcomes of ALLR with a knotless anchor. METHODS: Thirty-two patients (11 men and 21 women; mean age, 28 ± 14 years) who underwent ALLR with a knotless anchor from December 2015 to October 2020 were included. The mean follow-up period was 31 ± 11 months. The Japanese Society for Surgery of the Foot (JSSF) ankle-hindfoot scale and the Self-Administered Foot Evaluation Questionnaire (SAFE-Q) were used for clinical evaluation preoperatively and at the 2-year follow-up. Surgical complications, particularly knot irritation, were also examined. RESULTS: The JSSF scale scores were significantly improved, from 71.3 ± 13.1 preoperatively to 96.6 ± 5.1 postoperatively (P < 0.05), and the SAFE-Q showed similar improvement in all subscales (P < 0.05). One case had a complication of persistent pain around the lateral portal (3.1%). CONCLUSION: ALLR using a knotless anchor provided satisfactory clinical outcomes over 2 years, and no major complications, such as knot irritation, were observed. CASE SERIES: Level of Evidence, 4.

  Jan. 2024, Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology, 35, 15 - 19, English, International magazine

  Scientific journal


• 特集 膝蓋大腿関節障害の治療 小児に対する膝蓋骨不安定症の治療

  渡邉 秀, 松下 雄彦, 黒田 良祐

  金原出版, Jan. 2024, 整形･災害外科, 67(1) (1), 41 - 46, Japanese


• Clinical use of autologous adipose-derived stromal vascular fraction cell injections for hip osteoarthritis.

  Yuma Onoi, Tomoyuki Matsumoto, Satoshi Sobajima, Masanori Tsubosaka, Shinya Hayashi, Takehiko Matsushita, Hideki Iwaguro, Ryosuke Kuroda

  INTRODUCTION: Currently, studies on adipose-derived stromal vascular fraction (SVF) cells are attracting increasing attention because they have the potential to differentiate into a subset of cell types, such as bone marrow-derived mesenchymal stromal cells (MSCs), and are easier to harvest than MSCs, thus making them easier to apply clinically. This study evaluated the short-term clinical outcomes of SVF cell therapy for hip osteoarthritis (OA). METHODS: Forty-two patients were enrolled in this study; these patients received a single injection comprising an average of 3.8 (standard deviation [SD], ±1.3) × 107 SVF cells into the hip joint. All patients were followed-up for at least 6 months. The mean age of the patients was 60.2 years (SD, ±9.4 years). Kellgren-Lawrence (KL) grades II, III, and IV based on radiography were 13, 13, and 16 patients, respectively. SVF cells were obtained from the subcutaneous fat of the abdomen or breech using a Celution® 800/CRS system. The average cell viability of SVF cells was 90.8% (SD, ±2.8%). Clinical assessments were performed using the Harris Hip Score (HHS), Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) score, and visual analog scale (VAS) score to evaluate pain. Images were evaluated using radiography, and T2 mapping values were obtained using a 1.5-T magnetic resonance imaging system. These clinical and imaging assessments were followed from preoperatively to 6 months postoperatively. RESULTS: The HHS, JHEQ score, and VAS score improved significantly from 22.5 (SD, ±16.6), 26.6 (SD, ±11.3), and 75.5 (SD, ±15.8) preoperatively to 46.8 (SD, ±27.2), 39.4 (SD, ±19.7), and 46.5 (SD, ±27.9), respectively, at 6 months postoperatively. KL grade II showed significant improvement in clinical outcome from preoperative to postoperative, while KL grade IV showed slight or little improvement. The center edge angle, acetabular head index on the radiographs, and T2 mapping values did not change significantly from preoperatively to 6 months postoperatively. CONCLUSIONS: SVF cell injection in the hip joint showed good short-term clinical efficacy for reducing hip OA symptoms. SVF cell therapy is thus an innovative and effective treatment for hip OA.

  Dec. 2023, Regenerative therapy, 24, 94 - 102, English, International magazine

  Scientific journal


• Accuracy comparison of cup positioning during total hip arthroplasty using Hip Align and AR-Hip in the supine position.

  Masahiro Fujita, Shinya Hayashi, Yuichi Kuroda, Naoki Nakano, Toshihisa Maeda, Takehiko Matsushita, Tomoyuki Matsumoto, Ryosuke Kuroda

  INTRODUCTION: The aim of this study is to compare the accuracy of acetabular cup positioning between the accelerometer-based navigation system and the augmented reality-based navigation system during THA in the supine position. MATERIALS AND METHODS: This retrospective study included 66 patients (70 hips) who underwent THA using two types of portable navigation system, Hip Align or AR-Hip, in the spine position. The absolute difference between the intraoperative navigation record and postoperative measurement using computed tomography data was evaluated. Preoperative clinical factors that decreased the accuracy of cup positioning by ≥ 3° were analyzed via multiple logistic regression analyses. RESULTS: The average absolute error of inclination was 2.8 ± 2.6° in Hip Align and 2.7 ± 1.8° in AR-Hip, and absolute anteversion error was 2.5 ± 2.0° in Hip Align and 2.6 ± 2.2° in AR-Hip, and there was no significantly different between the two navigation systems. There was a significant association between the absolute measurement error (≥ 3°) of cup inclination and patients' BMI in the Hip Align group [odds ratio (OR) 1.350; 95% confidence interval (CI) 1.035-1.760; p = 0.027], but not in the AR-Hip group. CONCLUSIONS: The accuracy of the acetabular cup positioning between the Hip Align and AR-Hip showed no difference during THA in the spine position. The high BMI could have negative influence on the accuracy of cup positioning in THA using Hip Align, thus AR-Hip could be designable for obesity patients.

  Dec. 2023, Archives of orthopaedic and trauma surgery, 143(12) (12), 7229 - 7235, English, International magazine

  Scientific journal


• Intra-articular site-specific distribution of advanced glycation end products in the shoulder of patients with diabetes mellitus having rotator cuff tears.

  Tatsuo Kato, Issei Shinohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Tomoya Yoshikawa, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Advanced glycation end products (AGEs) are compounds formed due to aging and diabetes mellitus (DM). They activate NADPH oxidase (NOX) by binding to their receptors, thereby increasing the production of reactive oxygen species (ROS), which cause oxidative stress. In this study, we investigated the effects of AGEs on the tissues of the shoulder joint (such as rotator cuff synovium, and capsule) in patients with DM having rotator cuff tears. METHODS: This study included eight patients with DM who underwent surgical treatment for rotator cuff tears with contracture. The rotator cuff, synovium, and joint capsule were harvested at the time of surgery and evaluated by hematoxylin-eosin staining. Furthermore, immunostaining was used for evaluating AGEs and receptor for AGEs (RAGE), cell activity, ROS, and apoptosis. Quantitative real-time polymerase chain reaction (qPCR) was employed for the cellular evaluation of NOX, interleukins, RAGE, and collagen. RESULTS: The AGEs and RAGE staining as well as the ratio of ROS and apoptosis were in the following order: rotator cuff > joint capsule > synovium. In contrast, the cellular activity was significantly higher in the synovium than in the other regions. The type I collagen expression (as shown by qPCR) as well as the RAGE and NOX expressions were as follows: rotator cuff > joint capsule > synovium. Conversely, the expression of inflammatory cytokines (i.e., IL-6 and IL-1β) was higher in the synovium than in the other regions. CONCLUSIONS: Our study is among the first to evaluate the effects of AGEs on each tissue of the shoulder joint in patients with DM having rotator cuff tears and contractures. The accumulation of AGEs in each tissue of the shoulder joint could reveal the locations affected by DM, which can lead to a better understanding of the pathophysiology of DM-related shoulder diseases.

  Dec. 2023, Molecular biology reports, 50(12) (12), 10339 - 10349, English, International magazine

  Scientific journal


• Effect of Bone Metastasis Cancer Board on Spinal Surgery Outcomes: A Retrospective Study.

  Kunihiko Miyazaki, Yutaro Kanda, Yoshitada Sakai, Ryo Yoshikawa, Takashi Yurube, Yoshiki Takeoka, Hitomi Hara, Toshihiro Akisue, Ryosuke Kuroda, Kenichiro Kakutani

  Background and Objectives: Bone metastasis cancer boards (BMCBs) focusing on the management of bone metastases have been gathering much attention. However, the association of BMCBs with spinal surgery in patients with spinal metastases remains unclear. In this retrospective single-center observational study, we aimed to clarify the effect of a BMCB on spinal metastasis treatment. Materials and Methods: We reviewed consecutive cases of posterior decompression and/or instrumentation surgery for metastatic spinal tumors from 2008 to 2019. The BMCB involved a team of specialists in orthopedics, rehabilitation medicine, radiation oncology, radiology, palliative supportive care, oncology, and hematology. We compared demographics, eastern cooperative oncology group performance status (ECOGPS), Barthel index (BI), number of overall versus emergency surgeries, and primary tumors between patients before (2008-2012) and after (2013-2019) BMCB establishment. Results: A total of 226 patients including 33 patients before BMCB started were enrolled; lung cancer was the most common primary tumor. After BMCB establishment, the mean patient age was 5 years older (p = 0.028), the mean operating time was 34 min shorter (p = 0.025), the mean hospital stay was 34.5 days shorter (p < 0.001), and the mean BI before surgery was 12 points higher (p = 0.049) than before. Moreover, the mean number of surgeries per year increased more than fourfold to 27.6 per year (p < 0.01) and emergency surgery rates decreased from 48.5% to 29.0% (p = 0.041). Patients with an unknown primary tumor before surgery decreased from 24.2% to 9.3% (p = 0.033). Postoperative deterioration rates from 1 to 6 months after surgery of ECOGPS and BI after BMCB started were lower than before (p = 0.045 and p = 0.027, respectively). Conclusion: The BMCB decreased the emergency surgery and unknown primary tumor rate despite an increase in the overall number of spinal surgeries. The BMCB also contributed to shorter operation times, shorter hospital stays, and lower postoperative deterioration rates of ECOGPS and BI.

  Nov. 2023, Medicina (Kaunas, Lithuania), 59(12) (12), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• C-C Motif Chemokine Ligand 2 Enhances Macrophage Chemotaxis, Osteogenesis, and Angiogenesis during the Inflammatory Phase of Bone Regeneration.

  Issei Shinohara, Masanori Tsubosaka, Masakazu Toya, Max L Lee, Junichi Kushioka, Masatoshi Murayama, Qi Gao, Xueping Li, Ning Zhang, Simon Kwoon-Ho Chow, Tomoyuki Matsumoto, Ryosuke Kuroda, Stuart B Goodman

  Local cell therapy has recently gained attention for the treatment of joint diseases and fractures. Mesenchymal stem cells (MSCs) are not only involved in osteogenesis and angiogenesis, but they also have immunomodulatory functions, such as inducing macrophage migration during bone regeneration via macrophage crosstalk. C-C motif chemokine ligand 2 (CCL2), a known inflammatory mediator, is associated with the migration of macrophages during inflammation. This study examined the utility of CCL2 as a therapeutic target for local cell therapy. Using lentiviral vectors for rabbit MSCs, genetically modified CCL2 overexpressing MSCs were generated. Osteogenic differentiation assays were performed using MSCs with or without macrophages in co-culture, and cell migration assays were also performed. Additionally, co-cultures were performed with endothelial cells (ECs), and angiogenesis was evaluated using a tube formation assay. Overexpression of CCL2 did not affect bone formation under monoculture conditions but promoted chemotaxis and osteogenesis when co-cultured with macrophages. Furthermore, CCL2-overexpression promoted tube formation in co-culture with ECs. These results suggest that CCL2 induces macrophage chemotaxis and osteogenesis by promoting crosstalk between MSCs and macrophages; CCL2 also stimulates ECs to induce angiogenesis. These findings indicate that CCL2 may be a useful therapeutic target for local cell therapy in areas of bone loss.

  Nov. 2023, Biomolecules, 13(11) (11), English, International magazine

  Scientific journal


• Successful Total Knee Arthroplasty for Hoffa and Proximal Tibial Fractures: Report of Three Complex Cases After Failed Osteosynthesis Procedures.

  Takuma Maeda, Tomoyuki Matsumoto, Masahiro Fujita, Masanori Tsubosaka, Tomoyuki Kamenaga, Naoki Nakano, Yuichi Kuroda, Shinya Hayashi, Takahiro Niikura, Ryosuke Kuroda

  BACKGROUND Distal femoral and proximal tibial fractures often lead to nonunion and post-traumatic osteoarthritis, and total knee arthroplasty (TKA) has emerged as an effective alternative for older patients. This report includes 3 cases of successful TKA treatment. The cases involve a 42-year-old man and a 62-year-old man with Hoffa coronal fractures of the distal femur, and a 50-year-old man with a proximal tibial fracture. These patients underwent multiple osteosynthesis procedures before receiving TKA. CASE REPORT Case 1: A 42-year-old man with a displaced Hoffa's fracture had persistent knee pain. Nonunion post-initial fixation led to reoperation with iliac bone grafting and plate fixation. TKA using a Posterior Stabilized (PS)-type implant resulted in improved motion and function after 3 years. Case 2: A 62-year-old man suffered lateral condyle and ligament injuries from a displaced Hoffa's fracture. Despite plate fixation, dislocation occurred, requiring conversion. TKA with long-stem hinge-type implant, using augmentation block, led to enhanced stability and outcomes at 2 years. Case 3: A 50-year-old man's tibial nonunion, treated with plate fixation, resulted in infection and bone fusion. TKA using a constrained PS-type implant insert addressed the lateral tibial adhesions via iliotibial band (ITB) release and treated severe tibial plateau damage. Positive results were seen at 1 year. CONCLUSIONS The challenges of pseudarthrosis, like bone defects and compromised tissue, highlight the need for precise implant selection based on evaluations of bone quality, defects, knee stability, and hyperextension, rather than resorting to overly-constrained implants.

  Nov. 2023, The American journal of case reports, 24, e941187, English, International magazine

  Scientific journal


• Comparison study of periprosthetic bone remodeling between simultaneous bilateral total hip arthroplasty and unilateral total hip arthroplasty: a matched cohort study.

  Shinya Hayashi, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Shotaro Tachibana, Ryosuke Kuroda

  PURPOSE: The load-bearing pattern of periprosthetic bone may differ between patients who underwent simultaneous bilateral and unilateral total hip arthroplasty (THA). We investigated the differences in periprosthetic bone remodeling after simultaneous bilateral total hip arthroplasty and unilateral total hip arthroplasty. METHODS: This retrospective cohort study enrolled 154 consecutive patients undergoing THA using full hydroxyapatite (HA) compaction short stems. Patient characteristics including age, body mass index, University of California Los Angeles (UCLA) activity score, and bone shape of the proximal femur were adjusted by propensity score matching. Subsequently, periprosthetic bone mineral density changes were compared between simultaneous bilateral and unilateral THA. RESULTS: We found that bone mineral density loss in the simultaneous bilateral THA group was significantly higher in zones 6 and 7 at 24 months after THA (zone 6, p = 0.019; zone 7, p = 0.041). Periprosthetic bone mineral density loss was not associated with clinical factors, including age, body mass index, and daily activity. Additionally, we demonstrated that periprosthetic bone mineral density loss was higher in zones 1, 4, 6, and 7 of patients with a normal hip on the contralateral side after unilateral THA (zone 1, p = 0.041; zone 4, p = 0.041; zone 6, p = 0.037; zone7, p = 0.019). CONCLUSIONS: The postoperative periprosthetic bone remodeling was lower in patients who underwent simultaneous bilateral THA than in those who underwent unilateral THA, even though patient characteristics were adjusted by propensity matching. Further observation of periprosthetic bone mineral density loss is needed to clarify the differences between the groups.

  Nov. 2023, International orthopaedics, 47(11) (11), 2767 - 2772, English, International magazine

  Scientific journal


• Pseudarthrosis of Pelvic Fracture With Charcot Arthropathy Successfully Treated With Constrained Total Hip Arthroplasty.

  Toshiki Kitamura, Shinya Hayashi, Tomoyuki Matsumoto, Shingo Hashimoto, Naoki Nakano, Yuichi Kuroda, Takahiro Niikura, Ryosuke Kuroda

  Charcot arthropathy is a rapidly progressive and destructive form of arthropathy caused by various neurological diseases. Total hip arthroplasty (THA) is usually contraindicated in patients with Charcot arthropathy; however, recent studies have reported good results following THA in this patient population. Herein, we report a case of Charcot arthropathy secondary to syphilis in a patient who was successfully treated with constrained THA, a new type of THA. A 56-year-old man was injured in a car accident, and a displaced acetabular fracture was revealed three weeks later. He was treated conservatively but soon developed greater displacement of the fracture and femoral head destruction. The patient was referred to our hospital for further treatment. The patient had pelvic pseudarthrosis secondary to Charcot arthropathy at the time of the first visit to our hospital. First, THA was performed with the acetabular reconstruction of the deficient bone. However, the acetabular implant was displaced one week postoperatively. THA revision was performed using a constrained cup. Postoperatively, the patient exhibited good hip stability without dislocation. However, displacement of the acetabular cup occurred one year after the second surgery. We performed a re-revision of THA using a new type of constrained cup that offers a high level of constraint to maintain range of motion (ROM) and prevent dislocations. The patient was able to walk with a T-cane one year postoperatively. Herein, we report a difficult case of revision THA in a patient with Charcot arthropathy concomitant with syphilis. THA is usually contraindicated in patients with Charcot arthropathy; however, we propose that THA using constrained cups that offer a wider ROM may be a useful therapeutic strategy for the treatment of Charcot arthropathy.

  Nov. 2023, Cureus, 15(11) (11), e48295, English, International magazine


• 【偽関節治療のエキスパートを目指そう】偽関節に対する新しい治療法 CD34陽性細胞移植とBMP(bone morphogenetic protein)

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (株)メジカルビュー社, Nov. 2023, 関節外科, 42(11) (11), 1295 - 1302, Japanese


• Real-world comparative study of the efficacy of Janus kinase inhibitors in patients with rheumatoid arthritis: the ANSWER cohort study.

  Shinya Hayashi, Shotaro Tachibana, Toshihisa Maeda, Mai Yamashita, Iku Shirasugi, Yuzuru Yamamoto, Hirotaka Yamada, Takaichi Okano, Keisuke Nishimura, Yo Ueda, Sadao Jinnno, Jun Saegusa, Wataru Yamamoto, Koichi Murata, Takayuki Fujii, Kenichiro Hata, Ayaka Yoshikawa, Kosuke Ebina, Yuki Etani, Naofumi Yoshida, Hideki Amuro, Motomu Hashimoto, Ryota Hara, Masaki Katayama, Tadashi Okano, Ryosuke Kuroda

  OBJECTIVE: This multicentre, retrospective study compared the efficacy and safety of tofacitinib, baricitinib, peficitinib and upadacitinib in real-world clinical settings after minimizing selection bias and adjusting the confounding patient characteristics. METHOD: The 622 patients were selected from the ANSWER cohort database and treated with tofacitinib (TOF), baricitinib (BAR), peficitinib (PEF) or upadacitinib (UPA). The patient's background was matched using propensity score-based inverse probability of treatment weighting (IPTW) among four treatment groups. The values of Clinical Disease Activity Index (CDAI), C-reactive protein (CRP), and modified Health Assessment Questionnaire (mHAQ) after drug initiation and the remission or low disease activity (LDA) rates of CDAI at 6 months after drug initiation were compared among the four groups. Further, the predictive factor for TOF and BAR efficacy was analysed. RESULTS: The retention and discontinuation rates until 6 months after drug initiations were not significantly different among the four JAK inhibitors treatment groups. Mean CDAI value, CDAI remission rate, and CDAI-LDA rate at 6 months after drug initiation were not significantly different among treatment groups. Baseline CDAI (TOFA: OR 1.09, P < 0.001; BARI: OR 1.07, P < 0.001), baseline CRP (TOFA: OR 1.32, P = 0.049), baseline glucocorticoid dose (BARI: OR 1.18, 95% CI 1.01-1.38, P = 0.035), a number of previous biological or targeted synthetic disease-modifying antirheumatic drugs (biological/targeted synthetic DMARDs) (BARI: OR 1.36, P = 0.004) were predictive factors for resistance to CDAI-LDA achievement to JAK inhibitor treatment. CONCLUSION: The efficacy and safety of TOF, BAR, PEF and UPA were not significantly different for the treatment of patients with rheumatoid arthritis.

  Nov. 2023, Rheumatology (Oxford, England), English, International magazine

  [Refereed]

  Scientific journal


• 【偽関節治療のエキスパートを目指そう】偽関節に対する新しい治療法 CD34陽性細胞移植とBMP(bone morphogenetic protein)

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (株)メジカルビュー社, Nov. 2023, 関節外科, 42(11) (11), 1295 - 1302, Japanese


• Phase III clinical trial of autologous CD34 + cell transplantation to accelerate fracture nonunion repair.

  Ryosuke Kuroda, Takahiro Niikura, Tomoyuki Matsumoto, Tomoaki Fukui, Keisuke Oe, Yutaka Mifune, Hironobu Minami, Hiroshi Matsuoka, Kimikazu Yakushijin, Yoshiharu Miyata, Shinichiro Kawamoto, Tatsuo Kagimura, Yasuyuki Fujita, Atsuhiko Kawamoto

  BACKGROUND: We previously demonstrated that CD34 + cell transplantation in animals healed intractable fractures via osteogenesis and vasculogenesis; we also demonstrated the safety and efficacy of this cell therapy in an earlier phase I/II clinical trial conducted on seven patients with fracture nonunion. Herein, we present the results of a phase III clinical trial conducted to confirm the results of the previous phase studies using a larger cohort of patients. METHODS: CD34 + cells were mobilized via administration of granulocyte colony-stimulating factor, harvested using leukapheresis, and isolated using magnetic cell sorting. Autologous CD34 + cells were transplanted in 15 patients with tibia nonunion and 10 patients with femur nonunion, who were followed up for 52 weeks post transplantation. The main outcome was a reduction in time to heal the tibia in nonunion patients compared with that in historical control patients. We calculated the required number of patients as 15 based on the results of the phase I/II study. An independent data monitoring committee performed the radiographic assessments. Adverse events and medical device failures were recorded. RESULTS: All fractures healed during the study period. The time to radiological fracture healing was 2.8 times shorter in patients with CD34 + cell transplantation than in the historical control group (hazard ratio: 2.81 and 95% confidence interval 1.16-6.85); moreover, no safety concerns were observed. CONCLUSIONS: Our findings strongly suggest that autologous CD34 + cell transplantation is a novel treatment option for fracture nonunion. TRIAL REGISTRATION: UMIN-CTR, UMIN000022814. Registered on 22 June 2016.

  Oct. 2023, BMC medicine, 21(1) (1), 386 - 386, English, International magazine

  Scientific journal


• Trends of disease activity in Japanese patients over 75 years with rheumatoid arthritis from 2014 to 2021- the ANSWER cohort study.

  Hirotaka Yamada, Sadao Jinno, Toshihisa Maeda, Shinya Hayashi, Wataru Yamamoto, Akira Onishi, Hideo Onizawa, Tohru Takeuchi, Yuri Hiramatsu, Yasutaka Okita, Kosuke Ebina, Yonsu Son, Naofumi Yoshida, Ryu Watanabe, Ryota Hara, Mai Yamashita, Yoko Nose, Yuzuru Yamamoto, Takaichi Okano, Keisuke Nishimura, Yo Ueda, Sho Sendo, Motomu Hashimoto, Ryosuke Kuroda, Jun Saegusa

  OBJECTIVES: To investigate if disease activity among elderly RA patients over 75 years has changed over time in the real-world clinical setting. METHODS: Data from an observational multicentre registry of RA patients in Japan were analyzed. The primary outcome was to evaluate the changes in the proportion of very elderly RA patients (over 75 years) who achieved remission and low disease activity, from 2014 to 2021. The secondary outcome was to identify factors associated with remission and low disease activity by comparing demographic and clinical characteristics among the patients who had a study visit within the study period, using multivariate logistic regression. RESULTS: A total of 32 161 patient visits were identified from 2014 to 2021. The proportion of patients over 75 years increased from 16.5% to 26.9%, with biologics and targeted-synthetic disease modifying anti-rheumatic drugs (b/tsDMARDs) usage increasing and glucocorticoids usage decreasing, while conventional-synthetic DMARDs usage remained relatively stable. The proportion of RA patients over 75 years achieving remission and low disease activity significantly increased from 62.2% to 78.2% (p for trend < 0.001). A negative factor associated with achieving remission and low disease activity was glucocorticoid usage, seropositivity, and history of previous b/tsDMARDs use while MTX usage was associated positively, independent of other predictors. CONCLUSIONS: In our cohort, disease activity among very elderly RA patients has improved over time. The study suggests the importance of using a treat-to-target approach in very elderly RA patients to improve clinical outcomes.

  Oct. 2023, Rheumatology (Oxford, England), English, International magazine

  [Refereed]

  Scientific journal


• 左第2肋骨に生じた骨軟骨腫を胸腔鏡補助下に摘出した一例

  和田 悠花, 原 仁美, 澤田 良子, 田中 雄悟, 黒田 良祐, 秋末 敏宏

  (一社)中部日本整形外科災害外科学会, Oct. 2023, 中部日本整形外科災害外科学会雑誌, 66(秋季学会) (秋季学会), 318 - 318, Japanese


• 30年の経過を経てChronic expanding hematomaを合併し増大した大腿部Gossypiboma(ガーゼオーマ)の1例

  石田 雄也, 深瀬 直政, 藤原 周一, 原 仁美, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2023, 中部日本整形外科災害外科学会雑誌, 66(秋季学会) (秋季学会), 318 - 318, Japanese


• 四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2023, 中部日本整形外科災害外科学会雑誌, 66(秋季学会) (秋季学会), 250 - 250, Japanese


• Mycobacterium abscessus complex感染による骨髄炎・化膿性関節炎を持続局所抗菌薬灌流で治療した一例

  藤田 大樹, 新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2023, 中部日本整形外科災害外科学会雑誌, 66(秋季学会) (秋季学会), 312 - 312, Japanese


• 特徴的画像所見を示した脛骨慢性骨髄炎の一例

  古川 太河, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2023, 中部日本整形外科災害外科学会雑誌, 66(秋季学会) (秋季学会), 314 - 314, Japanese


• 骨転移患者に対するリハビリテーション治療効果 傾向スコアマッチングを用いた検討

  吉川 遼, 藤井 康光, 大西 宏和, 津田 悠三, 中村 謙, 鹿島 遼河, 佐保 航, 原田 理沙, 武岡 由樹, 澤田 良子, 深瀬 直政, 原 仁美, 角谷 賢一朗, 秋末 敏宏, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, Oct. 2023, The Japanese Journal of Rehabilitation Medicine, 60(秋季特別号) (秋季特別号), S355 - S355, Japanese


• 左第2肋骨に生じた骨軟骨腫を胸腔鏡補助下に摘出した一例

  和田 悠花, 原 仁美, 澤田 良子, 田中 雄悟, 黒田 良祐, 秋末 敏宏

  (一社)中部日本整形外科災害外科学会, Oct. 2023, 中部日本整形外科災害外科学会雑誌, 66(秋季学会) (秋季学会), 318 - 318, Japanese


• Talar component subsidence correlates with periprosthetic osteolysis after total ankle arthroplasty.

  Shinsuke Kihara, Noriyuki Kanzaki, Takahiro Yamashita, Tetsuya Yamamoto, Kyohei Nishida, Kanto Nagai, Daisuke Araki, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  PURPOSE: This study aimed to investigate the relationship between periprosthetic osteolysis around the talar component and the amount of talar component subsidence after total ankle arthroplasty (TAA). METHODS: This study included forty patients who underwent TAA with a mean follow-up of 67.5 ± 17.0 months. The patients were divided into two groups based on the amount of osteolysis around the talar component, as measured by computed tomography at the latest clinic visit: none to 2 mm (N group, n = 20) and greater than or equal to 2 mm (O group, n = 20). The average amount of talar component subsidence, clinical outcomes, and complications were compared between the two groups. In the O group, the correlation between osteolysis and talar component subsidence was evaluated. RESULTS: The average talar component subsidence was significantly different between the N (0.22 ± 0.94 mm) and O groups (2.12 ± 2.28 mm). Five out of 20 ankles in the O group required revision surgery owing to talar component subsidence. The Japanese Society for Surgery of the Foot scores in the N and O groups were significantly different: 93.5 ± 7.7 and 85.3 ± 15.4, respectively. In the O group, we found that osteolysis tended to develop on the lateral side, and the amount of osteolysis was positively correlated with the talar component subsidence (r = 0.59, P = .007). CONCLUSION: In the O group, a positive correlation between osteolysis and talar component subsidence was found, and five patients required revision surgery.

  Oct. 2023, European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 33(7) (7), 2987 - 2993, English, International magazine

  Scientific journal


• What it takes to have a high-grade pivot shift-focus on bony morphology.

  Sahil Dadoo, Emre Anil Ozbek, Koji Nukuto, Armin Runer, Laura E Keeling, Camila Grandberg, Ryosuke Kuroda, Stefano Zaffagnini, Jon Karlsson, Jonathan D Hughes, James J Irrgang, Volker Musahl

  PURPOSE: Variations in femoral and tibial bony morphology have been associated with higher clinical grading and increased quantitative tibial translation, but not tibial acceleration, during the pivot shift test following anterior cruciate ligament (ACL) injury. The purpose of this study was to determine the impact of femoral and tibial bony morphology, including a measurement influenced by both parameters (the Lateral Tibiofemoral Articular Distance (LTAD)), on the degree of quantitative tibial acceleration during the pivot shift test and rates of future ACL injury. METHODS: All patients who underwent primary ACL reconstruction from 2014 to 2019 by a senior orthopedic surgeon with available quantitative tibial acceleration data were retrospectively reviewed. All patients underwent a pivot shift examination under anesthesia with a triaxial accelerometer. Measurements of femoral and tibial bony morphology were performed by two fellowship-trained orthopedic surgeons using preoperative magnetic resonance imaging and lateral radiographs. RESULTS: Fifty-one patients were included at a mean follow-up of 4.4 years. The mean quantitative tibial acceleration during the pivot shift was 13.8 m/s2 (range: 4.9-52.0 m/s2). A larger Posterior Condylar Offset Ratio (r = 0.30, p = 0.045), smaller medial-to-lateral width of the medial tibial plateau (r = - 0.29, p = 0.041), lateral tibial plateau (r = - 0.28, p = 0.042), and lateral femoral condyle (r = - 0.29, p = 0.037), and a decreased LTAD (r = - 0.53, p < 0.001) significantly correlated with increased tibial acceleration during the pivot shift. Linear regression analysis demonstrated an increase in tibial acceleration of 1.24 m/s2 for every 1 mm decrease in LTAD. Nine patients (17.6%) sustained ipsilateral graft rupture and 10 patients (19.6%) sustained contralateral ACL rupture. No morphologic measurements were associated with rates of future ACL injury. CONCLUSION: Increased convexity and smaller bony morphology of the lateral femur and tibia were significantly associated with increased tibial acceleration during the pivot shift. Additionally, a measurement, termed the LTAD, was found to have the strongest association with increased tibial acceleration. Based on the results of this study, surgeons can utilize these measurements to preoperatively identify patients at risk of increased rotatory knee instability. LEVEL OF EVIDENCE: Level IV.

  Oct. 2023, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 31(10) (10), 4080 - 4089, English, International magazine

  Scientific journal


• Heterogeneous Cells as well as Adipose-Derived Stromal Cells in Stromal Vascular Fraction Contribute to Enhance Anabolic and Inhibit Catabolic Factors in Osteoarthritis.

  Kensuke Anjiki, Tomoyuki Matsumoto, Yuichi Kuroda, Masahiro Fujita, Shinya Hayashi, Naoki Nakano, Masanori Tsubosaka, Tomoyuki Kamenaga, Yoshinori Takashima, Kenichi Kikuchi, Kenmei Ikuta, Yuma Onoi, Shotaro Tachibana, Yoshihito Suda, Kensuke Wada, Takehiko Matsushita, Ryosuke Kuroda

  The stromal-vascular fraction (SVF), comprising heterogeneous cell populations and adipose-derived stromal cells (ADSCs), has therapeutic potential against osteoarthritis (OA); however, the underlying mechanism remains elusive. This study aimed to investigate the therapeutic effects of heterogeneous cells in rabbit SVF on rabbit chondrocytes. Rabbit SVF and ADSCs were autografted into knees at OA onset. The SVF (1 × 105) and low-dose ADSCs (lADSC; 1 × 104) groups adjusted for their stromal cell content were compared. Animals were euthanized 8 and 12 weeks after OA onset for macroscopic and histological analyses of OA progression and synovitis. Immunohistochemical and real-time polymerase chain reaction assessments were conducted. In vitro, immune-fluorescent double staining was performed for SVF to stain macrophages with F4/80, CD86(M1), and CD163(M2). OA progression was markedly suppressed, and synovitis was reduced in the SVF groups (OARSI histological score 8 W: 6.8 ± 0.75 vs. 3.8 ± 0.75, p = 0.001; 12 W: 8.8 ± 0.4 vs. 5.4 ± 0.49, p = 0.0002). The SVF groups had higher expression of collagen II and SOX9 in cartilage and TGF-β and IL-10 in the synovium, lower expression of MMP-13, and lower macrophage M1/M2 ratio than the lADSC groups. Immunofluorescent double staining revealed a markedly higher number of M2 than that of M1 macrophages in the SVF. The therapeutic effects of SVF on chondrocytes were superior than those of lADSCs, with enhanced anabolic and inhibited catabolic factors. Heterogeneous cells, mainly M2 macrophages in the SVF, enhanced growth factor secretion and chondrocyte-protective cytokines, thus benefiting chondrocytes and knee joint homeostasis. Overall, the SVF is a safe, relatively simple, and a useful treatment option for OA.

  Oct. 2023, Stem cell reviews and reports, 19(7) (7), 2407 - 2419, English, International magazine

  Scientific journal


• Clinical Outcomes After Anterior Cruciate Ligament Reconstruction in Patients With a Concomitant Segond Fracture: Response.

  Kanto Nagai, Kohei Kamada, Jeffrey Kay, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda, Darren de Sa

  Oct. 2023, The American journal of sports medicine, 51(12) (12), NP48-NP49, English, International magazine

  Scientific journal


• 人工足関節全置換術患者はいつ自動車の運転を再開することが可能か?

  松野 凌馬, 神崎 至幸, 上田 雄也, 蒲地 正宗, 佐野 翔平, 黒田 良祐

  (一社)日本足の外科学会, Oct. 2023, 日本足の外科学会雑誌, 44(Suppl.) (Suppl.), S337 - S337, Japanese


• 認定健康スポーツナースの救護活動に関する教育プログラム開発についての文献的考察

  峯山 佳恵, 葛西 好美, 中村 摩紀, 上田 雄也, 島 稔樹, 元野 紘平, 高島 良典, 武岡 由樹, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2023, 日本臨床スポーツ医学会誌, 31(4) (4), S232 - S232, Japanese


• 膝前十字靱帯再建術後1年における自覚的なパフォーマンスの復帰と関連因子の検討

  上田 雄也, 松下 雄彦, 柴田 洋平, 後藤 理生, 三浦 大祐, 西田 京平, 長井 寛斗, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2023, 日本臨床スポーツ医学会誌, 31(4) (4), S298 - S298, Japanese


• 高位脛骨骨切り術および脛骨粗面下骨切り術前後の膝伸展筋力の変化

  後藤 理生, 松下 雄彦, 上田 雄也, 柴田 洋平, 三浦 大祐, 小野 くみ子, 西田 京平, 長井 寛斗, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2023, 日本臨床スポーツ医学会誌, 31(4) (4), S301 - S301, Japanese


• 前十字靱帯再建術後感染に対して持続局所抗菌薬灌流療法を行い,移植腱を温存し得たプロサッカー選手の1例

  吉田 純伶, 松下 雄彦, 大江 啓介, 長井 寛斗, 西田 京平, 神崎 至幸, 星野 祐一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2023, 中部日本整形外科災害外科学会雑誌, 66(5) (5), 869 - 869, Japanese


• Targeting the neutral hip-to-calcaneus axis in kinematically aligned total knee arthroplasty is feasible with fewer alignment outliers for varus osteoarthritic patients.

  Tomoyuki Matsumoto, Naoki Nakano, Kazunari Ishida, Toshihisa Maeda, Shotaro Tachibana, Yuichi Kuroda, Shinya Hayashi, Takehiko Matsushita, Ryosuke Kuroda

  PURPOSE: Assessment of the conventional mechanical axis (MA) (hip-to-talus axis) is reported to result in constitutional varus in the native knee. However, the ground MA (hip-to-calcaneus axis), which is the line from the hip center to the bottom of the calcaneus, passes through the center of the knee joint in the native knee and is a possible alternative target for total knee arthroplasty (TKA) assessments. Therefore, this study aimed to present a "ground kinematically aligned (KA)-TKA." In this technique, the femoral component is placed on the cylindrical axis using the calipered technique and the tibial component is placed to give a neutral ground MA. Radiographical investigation was used to determine whether physiological alignment can be individually achieved with ground KA-TKA; this was compared with that of a tibia-restricted modified KA-TKA, referring to conventional MA (hip-to-talus axis) results. METHODS: As the primary endpoint, this prospective cohort study compared the ground MA ratios of the knee joints in 40 ground KA-TKAs (G group: Coronal Plain Alignment of the Knee (CPAK) 28 type I, 7 II, 1 IV, and 4 V) with those of the preceding 60 modified KA-TKAs (M group: CPAK 46 type I, 12 II, and 2 V) performed for patients with varus osteoarthritis (OA). The number of outliers differing over ± 5% from the neutral were compared between groups using the χ2-test. The Hip-knee-ankle (HKA) angle, coronal femoral/tibial component alignment (FCA/TCA), and joint line orientation angle (JLOA) were compared between the groups using non-paired t-tests. Statistical significance was set at p < 0.05. RESULTS: The G group had a higher ratio of the ground MA passing through the knee center than the M group did; outliers differing over ± 5% from the neutral of the ground MA were 2/40 cases in the G group and 20/60 cases in the M group, which was a significant difference (p = 0.001). The HKA angle, FCA/TCA, and JLOA were not significantly different between the groups. CONCLUSIONS: Targeting the ground MA in KA-TKA for patients with varus OA was feasible and has the potential to provide a physiological alignment more similar to the native knee in TKA than other kinematic alignment techniques. LEVEL OF EVIDENCE: Level III.

  Sep. 2023, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 31(9) (9), 3880 - 3888, English, International magazine

  Scientific journal


• Ground kinematically aligned total knee arthroplasty: new personalized technique which enables a stable knee with deep flexion.

  Tomoyuki Matsumoto, Naoki Nakano, Kazunari Ishida, Yuichi Kuroda, Shinya Hayashi, Hirotsugu Muratsu, Ryosuke Kuroda

  PURPOSE: This study aimed to evaluate kinematically aligned total knee arthroplasty (KA-TKA) targeting the neutral ground mechanical axis (MA) (hip-to-calcaneus axis), the line from the hip centre to the bottom of the calcaneus, (ground KA-TKA) in terms of its comparison with tibia-restricted modified KA-TKA (modified KA-TKA). METHODS: This retrospective cohort study included 106 consecutive patients who underwent unilateral KA-TKA for varus osteoarthritis (OA) (60 modified KA-TKAs and 46 ground KA-TKAs). After 1:1 propensity score matching, 60 patients (30 pairs) were matched between the groups with comparable demographic data. The hip-knee-ankle (HKA) angle, coronal femoral component alignment (FCA), and coronal tibial component alignment (TCA) were compared between groups. Intraoperative soft tissue balance, including the joint component gap and varus/valgus balance, was also compared between the groups. One year postoperatively, the clinical outcomes, including the range of motion and 2011 Knee Society Score, were compared between groups. RESULTS: The HKA angle and FCA/TCA were not significantly different between groups. Whereas the varus/valgus balance showed no significant differences between groups, smaller joint component gaps were found throughout the range of motion in the ground KA-TKA group than in the modified KA-TKA group. Despite no difference in clinical scores between groups, a significantly deeper postoperative flexion angle was achieved in the ground KA-TKA group than in the modified KA-TKA group (p < 0.05). CONCLUSION: Targeting neutral ground MA in KA-TKA for patients with varus OA has the potential to provide a better flexion angle with stable intraoperative soft tissue balance.

  Sep. 2023, International orthopaedics, 47(9) (9), 2215 - 2223, English, International magazine

  Scientific journal


• 【変わりゆくTKAのトレンド】Functional alignmentの実際

  石田 一成, 柴沼 均, 中野 直樹, 松本 知之, 黒田 良祐

  (株)メジカルビュー社, Sep. 2023, 関節外科, 42(9) (9), 985 - 990, Japanese


• 上腕骨近位端骨折続発症に対するリバース型人工肩関節置換術の小経験

  牟田口 由紀子, 美舩 泰, 乾 淳幸, 西本 華子, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2023, 中部日本整形外科災害外科学会雑誌, 66(5) (5), 727 - 728, Japanese


• 3D造形βTCP人工骨の生体活性の検討

  高瀬 恭平, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 山本 裕也, 西田 亮太, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1718 - S1718, Japanese


• 異なる抗菌薬濃度により骨髄由来細胞が受ける影響の検討

  山本 裕也, 大江 啓介, 福井 友章, 澤内 健一, 吉川 遼, 高瀬 恭平, 西田 亮太, 新倉 隆宏, 圓尾 明弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1723 - S1723, Japanese


• Masquelet法induced membrane由来細胞に対するLIPUSの骨分化促進効果の検討

  高瀬 恭平, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 山本 裕也, 西田 亮太, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1747 - S1747, Japanese


• 廃用性骨萎縮・筋萎縮に対する炭酸ガス経皮吸収の予防効果

  西田 亮太, 大江 啓介, 福井 友章, 澤内 健一, 山本 裕也, 高瀬 恭平, 吉川 遼, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1749 - S1749, Japanese


• 骨肉腫細胞におけるSPRR1Aの機能の探索

  宮本 智弘, 藤原 周一, 原 仁美, 深瀬 直政, 澤田 良子, 八尋 俊輔, 青井 貴之, 小柳 三千代, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1892 - S1892, Japanese


• 【成人脊柱変形とロコモ】脊椎矢状面アライメント・体幹バランスからみたロコモ患者へのロコトレ介入効果 手術によらない成人脊柱変形治療の可能性

  由留部 崇, 平中 良明, 竹岡 亨, 稲岡 秀陽, 角谷 賢一朗, 黒田 良祐, 渡邉 信佳

  (株)先端医学社, Aug. 2023, Loco Cure, 9(3) (3), 243 - 248, Japanese


• 扁平足手術におけるInternalBraceTMを使用したばね靱帯再建が術後成績に与える影響

  杜多 昭彦, 柴沼 均, 神崎 至幸, 黒田 良祐, 高倉 義幸, 高倉 義典

  (一社)日本足の外科学会, Aug. 2023, 日本足の外科学会雑誌, 44(1) (1), 108 - 111, Japanese


• 3D造形βTCP人工骨の生体活性の検討

  高瀬 恭平, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 山本 裕也, 西田 亮太, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1718 - S1718, Japanese


• 異なる抗菌薬濃度により骨髄由来細胞が受ける影響の検討

  山本 裕也, 大江 啓介, 福井 友章, 澤内 健一, 吉川 遼, 高瀬 恭平, 西田 亮太, 新倉 隆宏, 圓尾 明弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1723 - S1723, Japanese


• Masquelet法induced membrane由来細胞に対するLIPUSの骨分化促進効果の検討

  高瀬 恭平, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 山本 裕也, 西田 亮太, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1747 - S1747, Japanese


• 廃用性骨萎縮・筋萎縮に対する炭酸ガス経皮吸収の予防効果

  西田 亮太, 大江 啓介, 福井 友章, 澤内 健一, 山本 裕也, 高瀬 恭平, 吉川 遼, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1749 - S1749, Japanese


• Diagnosis of Developmental Dysplasia of the Hip by Ultrasound Imaging Using Deep Learning.

  Maki Kinugasa, Atsuyuki Inui, Shinichi Satsuma, Daisuke Kobayashi, Ryosuke Sakata, Masayuki Morishita, Izumi Komoto, Ryosuke Kuroda

  BACKGROUND: A timely diagnosis of developmental dysplasia of the hip (DDH) is important for satisfactory clinical outcomes. Ultrasonography is a useful tool for DDH screening; however, it is technically demanding. We hypothesized that deep learning could assist in the diagnosis of DDH. In this study, several deep-learning models were assessed to diagnose DDH on ultrasonograms. This study aimed to evaluate the accuracy of diagnoses made by artificial intelligence (AI) using deep learning on ultrasound images of DDH. METHODS: Infants who were up to 6 months old with suspected DDH were included. DDH diagnosis using ultrasonography was performed according to the Graf classification. Data on 60 infants (64 hips) with DDH and 131 healthy infants (262 hips) obtained from 2016 to 2021 were retrospectively reviewed. For deep learning, a MATLAB deep learning toolbox (MathWorks, Natick, MA, US) was used, and 80% of the images were used as training data, with the rest as validation data. Training images were augmented to increase data variation. In addition, 214 ultrasound images were used as test data to evaluate the AI's accuracy. Pre-trained models (SqueezeNet, MobileNet_v2, and EfficientNet) were used for transfer learning. Model accuracy was evaluated using a confusion matrix. The region of interest of each model was visualized using gradient-weighted class activation mapping (Grad-CAM), occlusion sensitivity, and image LIME. RESULTS: The best scores for accuracy, precision, recall, and F-measure were all 1.0 in each model. In DDH hips, the region of interest for deep learning models was the area lateral to the femoral head, including the labrum and joint capsule. However, for normal hips, the models highlighted the medial and proximal areas where the lower margin of the os ilium and the normal femoral head exist. CONCLUSIONS: Ultrasound imaging with deep learning can assess DDH with high accuracy. This system could be refined for a convenient and accurate diagnosis of DDH. LEVEL OF EVIDENCE: Level-Ⅳ.

  Aug. 2023, Journal of pediatric orthopedics, 43(7) (7), e538-e544, English, International magazine

  Scientific journal


• Clinical Characteristics and Surgical Outcomes of Metastatic Spine Tumors in the Very Elderly: A Prospective Cohort Study in a Super-Aged Society.

  Yutaro Kanda, Kenichiro Kakutani, Yoshitada Sakai, Kunihiko Miyazaki, Tomoya Matsuo, Takashi Yurube, Yoshiki Takeoka, Hiroki Ohnishi, Masao Ryu, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Teruya Kawamoto, Hitomi Hara, Yuichi Hoshino, Shinya Hayashi, Toshihiro Akisue, Ryosuke Kuroda

  The number of advanced-age patients with spinal metastases is rising. This study was performed to clarify the characteristics and surgical outcomes of spinal metastases in advanced-age patients. We prospectively analyzed 216 patients with spinal metastases from 2015 to 2020 and divided them into three age groups: <70 years (n = 119), 70-79 years (n = 73), and ≥80 years (n = 24). Although there were no significant intergroup differences in preoperative characteristics and surgery-related factors except for age, patients aged ≥80 years tended to have a worse performance status (PS), Barthel index, and EuroQol-5 dimension (EQ-5D) before and after surgery than the other two groups. Although the median PS, mean Barthel index and mean EQ-5D greatly improved postoperatively in each group, the median PS and mean Barthel index at 6 months and the mean EQ-5D at 1 month postoperatively were significantly poorer in the ≥80-year group than the 70-79-year group. The rates of postoperative complications and re-deterioration of the EQ-5D were significantly higher in the oldest group than in the other two groups. Although surgery for spinal metastases improved the PS, Barthel index, and EQ-5D regardless of age, clinicians should be aware of the poorer outcomes and higher complication rates in advanced-age patients.

  Jul. 2023, Journal of clinical medicine, 12(14) (14), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Measurement of Shoulder Abduction Angle with Posture Estimation Artificial Intelligence Model.

  Masaya Kusunose, Atsuyuki Inui, Hanako Nishimoto, Yutaka Mifune, Tomoya Yoshikawa, Issei Shinohara, Takahiro Furukawa, Tatsuo Kato, Shuya Tanaka, Ryosuke Kuroda

  Substantial advancements in markerless motion capture accuracy exist, but discrepancies persist when measuring joint angles compared to those taken with a goniometer. This study integrates machine learning techniques with markerless motion capture, with an aim to enhance this accuracy. Two artificial intelligence-based libraries-MediaPipe and LightGBM-were employed in executing markerless motion capture and shoulder abduction angle estimation. The motion of ten healthy volunteers was captured using smartphone cameras with right shoulder abduction angles ranging from 10° to 160°. The cameras were set diagonally at 45°, 30°, 15°, 0°, -15°, or -30° relative to the participant situated at a distance of 3 m. To estimate the abduction angle, machine learning models were developed considering the angle data from the goniometer as the ground truth. The model performance was evaluated using the coefficient of determination R2 and mean absolute percentage error, which were 0.988 and 1.539%, respectively, for the trained model. This approach could estimate the shoulder abduction angle, even if the camera was positioned diagonally with respect to the object. Thus, the proposed models can be utilized for the real-time estimation of shoulder motion during rehabilitation or sports motion.

  Jul. 2023, Sensors (Basel, Switzerland), 23(14) (14), English, International magazine

  Scientific journal


• Combining age, sex, body mass index, sport level, and preoperative quadriceps strength improves the predictive ability of quadriceps strength recovery after anterior cruciate ligament reconstruction.

  Yuya Ueda, Takehiko Matsushita, Yohei Shibata, Kohei Takiguchi, Kumiko Ono, Akihiro Kida, Kyohei Nishida, Kanto Nagai, Yuichi Hoshino, Tomoyuki Matsumoto, Yoshitada Sakai, Ryosuke Kuroda

  PURPOSE: This study compared the predictive ability of each independent predictor with that of a combination of predictors for quadriceps strength recovery one year after anterior cruciate ligament (ACL) reconstruction. METHODS: Patients who underwent primary ACL reconstruction using hamstring autografts were enrolled. Quadriceps strength, hamstring strength, and anterior tibial translation were measured, and the limb symmetry index (LSI) of the quadriceps and the hamstrings was calculated preoperatively and one year after surgery. Patients were classified into two groups according to the LSI of the quadriceps strength at one year postoperatively (≥ 80% or < 80%). Multivariate logistic regression analysis identified the independent predictors of quadriceps strength recovery, and the cut-off value was calculated using the receiver operating characteristic curve. A model assessing predictive ability of the combination of independent predictors was created, and the area under the curve (AUC) for each independent predictor was calculated by using the receiver-operating characteristic curves and the DeLong method. RESULTS: Of the 646 patients, 414 (64.1%) had an LSI of at least 80% for quadriceps strength one year after surgery, and 232 patients (35.9%) had an LSI of < 80%. Age, sex, body mass index (BMI), preinjury sport level, and LSI of preoperative quadriceps strength were independently associated with quadriceps strength recovery one year after ACL reconstruction. The cut-off values were age: 22.5 years; sex: female; BMI: 24.3 kg/m2; preinjury sport level: no sport; and LSI of preoperative quadriceps strength: 63.3%. The AUC of the model assessing the predictive ability of the combination of age, sex, BMI, preinjury sport level, and LSI of preoperative quadriceps strength was significantly higher (0.73) than that of similar factors of preoperative quadriceps strength (AUC: 0.63, 0.53, 0.56, 0.61, and 0.68, p < 0.01, respectively). CONCLUSION: The combination of age, sex, BMI, preinjury sport level, and LSI of preoperative quadriceps strength had a superior predictive ability for quadriceps strength recovery at one year after ACL reconstruction than these predictors alone. Multiple factors, including patient characteristics and preoperative quadriceps strength, should be considered when planning rehabilitation programs to improve quadriceps strength recovery after ACL reconstruction. LEVEL OF EVIDENCE: III.

  Jun. 2023, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 高齢者の上肢に生じた切除不能な粘液線維肉腫に対するBNCTを用いた新たな治療法についての検討

  藤本 卓也, 安藤 徹, 須藤 保, 藤田 郁夫, 角田 雅也, 竹森 俊幸, 河本 旭哉, 秋末 敏宏, 黒田 良祐, 鈴木 実

  (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1429 - S1429, Japanese


• 小児中足骨発生の類上皮血管内皮腫の1例

  藤原 周一, 河本 旭哉, 原 仁美, 深瀬 直政, 澤田 良子, 八尋 俊輔, 宮本 智弘, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1382 - S1382, Japanese


• 骨肉腫細胞におけるSPRR1Aの機能の探索

  宮本 智弘, 藤原 周一, 河本 旭哉, 原 仁美, 深瀬 直政, 澤田 良子, 八尋 俊輔, 青井 貴之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1435 - S1435, Japanese


• 化学療法と炭素イオン線治療により5年生存し,歩行機能を温存しえた71歳の寛骨臼骨肉腫の1例

  深瀬 直政, 藤原 周一, 竹森 俊幸, 出水 祐介, 沖本 智昭, 澤田 良子, 原 仁美, 河本 旭哉, 秋末 敏宏, 黒田 良祐

  (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1439 - S1439, Japanese


• 本邦における骨盤発生悪性骨・軟部腫瘍に対する手術と粒子線の治療成績の比較

  竹森 俊幸, 河本 旭哉, 藤田 郁夫, 藤本 卓也, 原 仁美, 深瀬 直政, 澤田 良子, 藤原 周一, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1440 - S1440, Japanese


• Prosthetic orientation, limb alignment, and soft tissue balance with bi-cruciate stabilized total knee arthroplasty: a comparison between the handheld robot and conventional techniques.

  Tomoyuki Matsumoto, Naoki Nakano, Shinya Hayashi, Koji Takayama, Toshihisa Maeda, Kazunari Ishida, Yuichi Kuroda, Takehiko Matsushita, Takahiro Niikura, Hirotsugu Muratsu, Ryosuke Kuroda

  PURPOSE: This study aimed to examine the prosthetic orientations, limb alignment, intraoperative soft tissue balance, and early clinical outcomes associated with the use of the relatively new handheld robot technique compared to those associated with the use of the conventional alignment guide for bi-cruciate stabilized total knee arthroplasty (TKA). METHODS: This retrospective cohort study compared the prosthetic orientation and limb alignment of 35 patients who underwent TKA using robotic assistance (robot group) with those of patients who underwent TKA using a conventional alignment guide (control group). The coronal femoral component alignment (FCA), coronal tibial component alignment (TCA), and the hip-knee-ankle (HKA) angle were compared between groups. Intraoperative soft tissue balance, including the joint component gap and varus/valgus balance assessed by an offset-type tensor, were also compared between groups. One year postoperatively, the clinical outcomes, including the range of motion and 2011 Knee Society Score (KSS), were compared between groups. RESULTS: The HKA angle and FCA were 0.1° varus and 0.1° varus, respectively, in the robot group and 1.3° varus and 1.3° varus, respectively, in the control group. The difference in the HKA angle and the FCA, but not the TCA, between groups was statistically significant (p < 0.05). The intraoperative soft tissue balance showed more stable joint component gaps and varus/valgus balances throughout the range of motion in the robot group than in the control group. Clinical outcomes of the robot group showed superior 2011 KSS subscales compared to those of the control group. CONCLUSION: The accuracy of the implantations and stable soft tissue balance in the robot group were superior to those of the control group. The robot group also had superior patient-reported scores for early clinical outcomes.

  Jun. 2023, International orthopaedics, 47(6) (6), 1473 - 1480, English, International magazine

  Scientific journal


• Intervertebral disc cell fate during aging and degeneration: apoptosis, senescence, and autophagy.

  Takashi Yurube, Yoshiki Takeoka, Yutaro Kanda, Ryosuke Kuroda, Kenichiro Kakutani

  BACKGROUND: Degenerative disc disease, a major cause of low back pain and associated neurological symptoms, is a global health problem with the high morbidity, workforce loss, and socioeconomic burden. The present surgical strategy of disc resection and/or spinal fusion results in the functional loss of load, shock absorption, and movement; therefore, the development of new biological therapies is demanded. This achievement requires the understanding of intervertebral disc cell fate during aging and degeneration. METHODS: Literature review was performed to clarify the current concepts and future perspectives of disc cell fate, focused on apoptosis, senescence, and autophagy. RESULTS: The intervertebral disc has a complex structure with the nucleus pulposus (NP), annulus fibrosus (AF), and cartilage endplates. While the AF arises from the mesenchyme, the NP originates from the notochord. Human disc NP notochordal phenotype disappears in adolescence, accompanied with cell death induction and chondrocyte proliferation. Discs morphologically and biochemically degenerate from early childhood as well, thereby suggesting a possible involvement of cell fate including age-related phenotypic changes in the disease process. As the disc is the largest avascular organ in the body, nutrient deprivation is a suspected contributor to degeneration. During aging and degeneration, disc cells undergo senescence, irreversible growth arrest, producing proinflammatory cytokines and matrix-degradative enzymes. Excessive stress ultimately leads to programmed cell death including apoptosis, necroptosis, pyroptosis, and ferroptosis. Autophagy, the intracellular degradation and recycling system, plays a role in maintaining cell homeostasis. While the incidence of apoptosis and senescence increases with age and degeneration severity, autophagy can be activated earlier, in response to limited nutrition and inflammation, but impaired in aged, degenerated discs. The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) is a signal integrator to determine disc cell fate. CONCLUSIONS: Cell fate and microenvironmental regulation by modulating PI3K/Akt/mTOR signaling is a potential biological treatment for degenerative disc disease.

  Jun. 2023, North American Spine Society journal, 14, 100210 - 100210, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 【まだできる!難治性疼痛の緩和ケア】(第I章)治療モダリティを知る 難治性疼痛を前提としたインターベンショナル治療 難治性疼痛に対する整形外科の引き出し

  角谷 賢一朗, 由留部 崇, 武岡 由樹, 宮崎 邦彦, 平中 良明, 黒田 良祐

  Jun. 2023, 緩和ケア, 33(6) (6), 107 - 113


• 【FRIの診断と治療-骨折手術後感染の疑問に答える】巨大骨欠損の再建 Masquelet法

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (株)医学書院, Jun. 2023, 臨床整形外科, 58(6) (6), 787 - 797, Japanese


• CLAP(1) 骨髄由来細胞に対する高濃度抗菌薬の影響

  山本 裕也, 大江 啓介, 福井 友章, 澤内 健一, 高瀬 恭平, 西田 亮太, 新倉 隆宏, 圓尾 明弘, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S87 - S87, Japanese


• CLAP(1) 当院における慢性骨髄炎に対する持続局所抗菌薬灌流療法(CLAP)の治療成績

  大江 啓介, 福井 友章, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S90 - S90, Japanese


• 大腿骨骨欠損をMasquelet法で治療する際の移植骨局所担持のための工夫

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S239 - S239, Japanese


• LIPUSのMasquelet法induced membrane由来細胞に対する骨分化促進効果の検討

  高瀬 恭平, 福井 友章, 大江 啓介, 山本 裕也, 西田 亮太, 新倉 隆宏, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S243 - S243, Japanese


• がん骨転移に対する骨修飾薬使用歴が非定型大腿骨骨折の治療経過に与える影響に関する後ろ向き観察研究

  福井 友章, 大江 啓介, 澤内 健一, 新倉 隆宏, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S254 - S254, Japanese


• 四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S279 - S279, Japanese


• 大腿骨頸部骨折患者における骨粗鬆症治療薬介入とステム周囲骨密度変化率の関係について 多施設共同研究

  大江 啓介, 福井 友章, 澤内 健一, 松宮 豊, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S340 - S340, Japanese


• 炭酸ガス経皮吸収と低出力超音波パルス療法(LIPUS)併用のラット大腿骨骨折治癒に対する効果

  西田 亮太, 澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 山本 裕也, 高瀬 恭平, 吉川 遼, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S368 - S368, Japanese


• Mycobacterium abscessus complex感染による骨髄炎・化膿性関節炎を持続局所抗菌薬灌流で治療した一例

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S474 - S474, Japanese


• 高濃度抗菌薬が骨髄由来細胞の増殖能および分化能に与える影響

  山本 裕也, 大江 啓介, 福井 友章, 澤内 健一, 吉川 遼, 高瀬 恭平, 西田 亮太, 新倉 隆宏, 圓尾 明弘, 黒田 良祐

  (一社)日本骨・関節感染症学会, Jun. 2023, 日本骨・関節感染症学会プログラム・抄録集, 46回, 120 - 120, Japanese


• CLAPにおけるゲンタマイシンの血中濃度、排液中濃度と排液量の関係

  松宮 豊, 大江 啓介, 福井 友章, 澤内 健一, 新倉 隆宏, 黒田 良祐

  (一社)日本骨・関節感染症学会, Jun. 2023, 日本骨・関節感染症学会プログラム・抄録集, 46回, 121 - 121, Japanese


• 当院における化膿性関節炎に対する持続局所抗菌薬灌流療法(CLAP)の治療成績

  大江 啓介, 福井 友章, 澤内 健一, 松宮 豊, 新倉 隆宏, 黒田 良祐

  (一社)日本骨・関節感染症学会, Jun. 2023, 日本骨・関節感染症学会プログラム・抄録集, 46回, 131 - 131, Japanese


• 脊椎転移手術における悪性度別手術成績比較

  大西 洋輝, 角谷 賢一朗, 由留部 崇, 武岡 由樹, 神田 裕太郎, 宮崎 邦彦, 平中 良明, 酒井 良忠, 秋末 敏宏, 黒田 良祐

  (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1352 - S1352, Japanese


• 小児中足骨発生の類上皮血管内皮腫の1例

  藤原 周一, 河本 旭哉, 原 仁美, 深瀬 直政, 澤田 良子, 八尋 俊輔, 宮本 智弘, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1382 - S1382, Japanese


• 高齢者の上肢に生じた切除不能な粘液線維肉腫に対するBNCTを用いた新たな治療法についての検討

  藤本 卓也, 安藤 徹, 須藤 保, 藤田 郁夫, 角田 雅也, 竹森 俊幸, 河本 旭哉, 秋末 敏宏, 黒田 良祐, 鈴木 実

  (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1429 - S1429, Japanese


• 骨肉腫細胞におけるSPRR1Aの機能の探索

  宮本 智弘, 藤原 周一, 河本 旭哉, 原 仁美, 深瀬 直政, 澤田 良子, 八尋 俊輔, 青井 貴之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1435 - S1435, Japanese


• 化学療法と炭素イオン線治療により5年生存し,歩行機能を温存しえた71歳の寛骨臼骨肉腫の1例

  深瀬 直政, 藤原 周一, 竹森 俊幸, 出水 祐介, 沖本 智昭, 澤田 良子, 原 仁美, 河本 旭哉, 秋末 敏宏, 黒田 良祐

  (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1439 - S1439, Japanese


• 本邦における骨盤発生悪性骨・軟部腫瘍に対する手術と粒子線の治療成績の比較

  竹森 俊幸, 河本 旭哉, 藤田 郁夫, 藤本 卓也, 原 仁美, 深瀬 直政, 澤田 良子, 藤原 周一, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1440 - S1440, Japanese


• 高濃度抗菌薬が骨髄由来細胞の増殖能および分化能に与える影響

  山本 裕也, 大江 啓介, 福井 友章, 澤内 健一, 吉川 遼, 高瀬 恭平, 西田 亮太, 新倉 隆宏, 圓尾 明弘, 黒田 良祐

  (一社)日本骨・関節感染症学会, Jun. 2023, 日本骨・関節感染症学会プログラム・抄録集, 46回, 120 - 120, Japanese


• CLAPにおけるゲンタマイシンの血中濃度、排液中濃度と排液量の関係

  松宮 豊, 大江 啓介, 福井 友章, 澤内 健一, 新倉 隆宏, 黒田 良祐

  (一社)日本骨・関節感染症学会, Jun. 2023, 日本骨・関節感染症学会プログラム・抄録集, 46回, 121 - 121, Japanese


• 当院における化膿性関節炎に対する持続局所抗菌薬灌流療法(CLAP)の治療成績

  大江 啓介, 福井 友章, 澤内 健一, 松宮 豊, 新倉 隆宏, 黒田 良祐

  (一社)日本骨・関節感染症学会, Jun. 2023, 日本骨・関節感染症学会プログラム・抄録集, 46回, 131 - 131, Japanese


• Multicenter study on atypical femoral fractures in patients with bone metastases taking bone- modifying agents.

  Tomoaki Fukui, Keisuke Oe, Teruya Kawamoto, Masayuki Morishita, Ikuo Fujita, Shunsuke Takahara, Atsushi Sakurai, Takashi Iwakura, Keiji Yoshida, Kenjiro Ito, Etsuo Shoda, Takafumi Hiranaka, Masaya Tsunoda, Ryosuke Kuroda, Takahiro Niikura

  Bone-modifying agents (BMAs), with bone-resorptive inhibitory effects, such as zoledronic acid and denosumab, are widely used at higher doses for bone-related events caused by bone metastasis of malignant tumors. These drugs have been suggested to be associated with atypical femoral fractures (AFFs), and the relationship between BMAs and AFFs has attracted attention. To investigate the clinical features including bone union time of AFFs in patients administered BMA for bone metastasis, we conducted a retrospective multicenter study. Thirty AFFs from 19 patients were enrolled in this study. Thirteen patients had bilateral AFFs, and nineteen AFFs had prodromal symptoms. Eighteen AFFs underwent surgery after complete fracture, three failed to achieve bone union and required nonunion surgery, and 11 AFFs that achieved bone union had an average period until bone union of 16.2 months, which was much longer than that previously reported for ordinary AFFs. Seven patients discontinued the BMAs, but not due to AFFs. Stopping BMAs in patients with bone metastasis would make it difficult to secure their performance of activities of daily living, and AFF with BMA administration might require a longer time for union. Therefore, it would be important to prevent incomplete AFF from becoming complete AFF via prophylactic internal fixation.

  Jun. 2023, Journal of bone oncology, 40, 100478 - 100478, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Preoperative Base Excess as a Predictor of Perioperative Complications in Patients with Nonidiopathic Scoliosis who Have High Risk Associated with General Anesthesia.

  Yutaro Kanda, Kenichiro Kakutani, Moritoki Egi, Zhongying Zhang, Takashi Yurube, Yoshiki Takeoka, Kunihiko Miyazaki, Hiroki Ohnishi, Tomoya Matsuo, Masao Ryu, Yuichi Hoshino, Ryosuke Kuroda

  INTRODUCTION: Patients with nonidiopathic scoliosis often have a high risk associated with general anesthesia because of cardiac or pulmonary dysfunction secondary to underlying diseases. Base excess has been reported as a predictor in the management of trauma and cancer, although not yet in scoliosis. This study was performed to clarify the surgical outcomes and the association of perioperative complications with base excess in patients with nonidiopathic scoliosis who have a high risk associated with general anesthesia. METHODS: Patients with nonidiopathic scoliosis who were referred to our institution from 2009 to 2020 because of their high risk associated with general anesthesia were retrospectively enrolled. High-risk factors for anesthesia were determined by a senior anesthesiologist and categorized into circulatory or pulmonary dysfunction. Perioperative complications were analyzed using the Clavien-Dindo classification; severe complications were defined as grade ≥III. We investigated high-risk factors for anesthesia, underlying diseases, preoperative and postoperative Cobb angle, surgery-related factors, base excess, and postoperative management. These variables were statistically compared between patients with and without complications. RESULTS: Thirty-six patients (mean age, 17.9 years old; range, 11-40 years old) were enrolled (two patients declined surgery). High-risk factors were circulatory dysfunction in 16 patients and pulmonary dysfunction in 20 patients. The mean Cobb angle improved from 85.1° (36°-128°) preoperatively to 43.6° (9°-83°) postoperatively. Three intraoperative complications and 23 postoperative complications occurred in 20 (55.6%) patients. Severe complications occurred in 10 (27.8%) patients. All patients underwent postoperative intensive care unit management after posterior all-screw construction. A large preoperative Cobb angle (p=0.021) and base excess outliers (>3 or <-3 mEq/L) (p=0.005) were significant risk factors for complications. CONCLUSIONS: Patients with nonidiopathic scoliosis who have a high risk associated with general anesthesia have a higher complication rate. Preoperative large deformity and base excess (>3 or <-3 mEq/L) could be predictors of complications.

  May 2023, Spine surgery and related research, 7(3) (3), 268 - 275, English, Domestic magazine

  Scientific journal


• Anti-Inflammatory Effects of Adiponectin Receptor Agonist AdipoRon against Intervertebral Disc Degeneration.

  Hiroki Ohnishi, Zhongying Zhang, Takashi Yurube, Yoshiki Takeoka, Yutaro Kanda, Ryu Tsujimoto, Kunihiko Miyazaki, Tomoya Matsuo, Masao Ryu, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Ryosuke Kuroda, Kenichiro Kakutani

  Adiponectin, a hormone secreted by adipocytes, has anti-inflammatory effects and is involved in various physiological and pathological processes such as obesity, inflammatory diseases, and cartilage diseases. However, the function of adiponectin in intervertebral disc (IVD) degeneration is not well understood. This study aimed to elucidate the effects of AdipoRon, an agonist of adiponectin receptor, on human IVD nucleus pulposus (NP) cells, using a three-dimensional in vitro culturing system. This study also aimed to elucidate the effects of AdipoRon on rat tail IVD tissues using an in vivo puncture-induced IVD degeneration model. Analysis using quantitative polymerase chain reaction demonstrated the downregulation of gene expression of proinflammatory and catabolic factors by interleukin (IL)-1β (10 ng/mL) in human IVD NP cells treated with AdipoRon (2 μM). Furthermore, western blotting showed AdipoRon-induced suppression of p65 phosphorylation (p < 0.01) under IL-1β stimulation in the adenosine monophosphate-activated protein kinase (AMPK) pathway. Intradiscal administration of AdipoRon was effective in alleviating the radiologic height loss induced by annular puncture of rat tail IVD, histomorphological degeneration, production of extracellular matrix catabolic factors, and expression of proinflammatory cytokines. Therefore, AdipoRon could be a new therapeutic candidate for alleviating the early stage of IVD degeneration.

  May 2023, International journal of molecular sciences, 24(10) (10), English, International magazine

  Scientific journal


• 【変形性関節症の診断と治療--保存的治療から再生医療まで】(VII章)変形性膝関節症 変形性膝関節症に対する人工膝関節全置換術(ロボット手術)

  石田 一成, 柴沼, 均, 黒坂 昌弘, 中野 直樹, 松本 知之, 黒田 良祐

  May 2023, 整形外科, 74(6) (6), 695 - 699


• Acute Deterioration of Patient with Sudden Onset of Shock Caused by Group G Streptococcus Infection after Revision Total Knee Arthroplasty: A Case Report.

  Kensuke Wada, Tomoyuki Matsumoto, Kemmei Ikuta, Masanori Tsubosaka, Naoki Nakano, Toshihisa Maeda, Yuichi Kuroda, Shinya Hayashi, Ryosuke Kuroda

  BACKGROUND Periprosthetic joint infection is a difficult complication, especially in patients with rheumatoid arthritis. Life-threatening septic shock due to periprosthetic joint infection caused by group G streptococcus is rare, and there have been few reports about its treatment. We describe a successful case of sudden onset septic shock due to group G Streptococcus infection after revision total knee arthroplasty. CASE REPORT A 61-year-old woman with rheumatoid arthritis treated with biological disease-modifying antirheumatic drugs for about 12 years presented with acute right knee pain and shock 6 months after revision total knee arthroplasty. Periprosthetic joint infection caused by group G Streptococcus was diagnosed. She was admitted to the Intensive Care Unit, treated with respiratory support and dialysis, and underwent irrigation, debridement, and polyethylene liner exchange as the first surgery. At 9 days after the first surgery, she underwent the second surgery, consisting of implant removal and antibiotic spacer placement due to failure. It took approximately 7 weeks to normalize the levels of systemic markers of inflammation with intravenous antibiotics and then oral antibiotics for further 12 weeks, but re-revision total knee arthroplasty was successfully performed 1.5 years later. At a 1-year follow-up from the final surgery, she was able to walk with a cane and had no symptoms of infection. CONCLUSIONS In such cases with sudden onset of septic shock due to periprosthetic joint infection, appropriate and prompt surgical treatment should be performed to save the infected limb as well as the patient's life.

  Apr. 2023, The American journal of case reports, 24, e938905, English, International magazine

  Scientific journal


• Dynamic Analysis of the Coracohumeral Ligament Using Ultra-Sonography in Shoulder Contracture.

  Tatsuo Kato, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Tomoya Yoshikawa, Issei Shinohara, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Ryosuke Kuroda

  The coracohumeral ligament (CHL) is related to the range of motion of the shoulder joint. The evaluation of the CHL using ultrasonography (US) has been reported on the elastic modulus and thickness of the CHL, but no dynamic evaluation method has been established. We aimed to quantify the movement of the CHL by applying Particle Image Velocimetry (PIV), a technique used in the field of fluid engineering, to cases of shoulder contracture using the US. The subjects were eight patients, with 16 shoulders. The coracoid process was identified from the body surface, and a long-axis US image of the CHL parallel to the subscapularis tendon was drawn. The shoulder joint was moved from 0 degrees of internal/external rotation to 60 degrees of internal rotation at a rhythm of one reciprocation every 2 s. The velocity of the CHL movement was quantified by the PIV method. The mean magnitude velocity of CHL was significantly faster on the healthy side. The maximum magnitude velocity was significantly faster on the healthy side. The results suggest that the PIV method is helpful as a dynamic evaluation method, and in patients with shoulder contracture, the CHL velocity was significantly decreased.

  Apr. 2023, Sensors (Basel, Switzerland), 23(8) (8), English, International magazine

  Scientific journal


• Elicitation of Inhibitory Effects for AGE-Induced Oxidative Stress in Rotator Cuff-Derived Cells by Apocynin.

  Takahiro Furukawa, Takashi Kurosawa, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Yasuhiro Ueda, Takeshi Kataoka, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Issei Shinohara, Tatsuo Kato, Shuya Tanaka, Masaya Kusunose, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  Advanced glycation end-products (AGEs) play a critical supportive role during musculoskeletal disorders via glycosylation and oxidative stress. Though apocynin, identified as a potent and selective inhibitor of NADPH oxidase, has been reported to be involved in pathogen-induced reactive oxygen species (ROS), its role in age-related rotator cuff degeneration has not been well clarified. Therefore, this study aims to evaluate the in vitro effects of apocynin on human rotator cuff-derived cells. Twelve patients with rotator cuff tears (RCTs) participated in the study. Supraspinatus tendons from patients with RCTs were collected and cultured. After the preparation of RC-derived cells, they were divided into four groups (control group, control + apocynin group, AGEs group, AGEs + apocynin group), and gene marker expression, cell viability, and intracellular ROS production were evaluated. The gene expression of NOX, IL-6, and the receptor for AGEs (RAGE) was significantly decreased by apocynin. We also examined the effect of apocynin in vitro. The results showed that ROS induction and increasing apoptotic cells after treatment of AGEs were significantly decreased, and cell viability increased considerably. These results suggest that apocynin can effectively reduce AGE-induced oxidative stress by inhibiting NOX activation. Thus, apocynin is a potential prodrug in preventing degenerative changes of the rotor cuff.

  Apr. 2023, Current issues in molecular biology, 45(4) (4), 3434 - 3445, English, International magazine

  Scientific journal


• Effect of low-intensity pulsed ultrasound on osteogenic differentiation of human induced membrane-derived cells in Masquelet technique.

  Kyohei Takase, Tomoaki Fukui, Keisuke Oe, Kenichi Sawauchi, Ryo Yoshikawa, Yuya Yamamoto, Shinya Hayashi, Tomoyuki Matsumoto, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: The Masquelet technique is a relatively new method for large bone defect treatment. In this technique, grafted bone tissue is used, and after the cement is removed, the induced membrane (IM; that form around the cement spacers placed in the bone defect region) is thought to play an important role in promoting bone formation. On the other hand, low-intensity pulsed ultrasound (LIPUS) is known to promote fracture healing and angiogenesis through mechanical stimulation. This study aimed to investigate the in vitro effects of LIPUS on the osteogenic differentiation of human induced membrane-derived cells (IMCs). METHODS: Seven patients who had been treated using the Masquelet technique were enrolled. The IM was harvested during the second stage of the technique. IMCs were isolated, cultured in growth medium, and then divided into two groups: (1) control group, IMCs cultured in osteogenic medium without LIPUS, and (2) LIPUS group, IMCs cultured in osteogenic medium with LIPUS treatment. Adherent cells from the IM samples were harvested after the first passage and evaluated for cell surface protein expression using immunostaining. A cell proliferation assay was used to count the number of IMCs using a hemocytometer. Osteogenic differentiation capability was assessed using an alkaline phosphatase (ALP) activity assay, Alizarin Red S staining, and real-time reverse transcription-polymerase chain reaction. RESULTS: Cell surface antigen profiling revealed that the IMCs contained cells positive for the mesenchymal stem cell-related markers CD73, CD90, and CD105. No significant difference in cell numbers was found between the control and LIPUS groups. The ALP activity of IMCs in the LIPUS group was significantly higher than that in the control group on days 7 and 14. Alizarin red S staining intensity was significantly higher in the LIPUS group than in the control group on day 21. Runx2 and VEGF expression was significantly upregulated on days 7 and 14, respectively, compared with levels in the control group. CONCLUSION: We demonstrated the significant effect of LIPUS on the osteogenic differentiation of human IMCs. This study indicates that LIPUS can be used as an additional tool for the enhancement of the healing process of the Masquelet technique.

  Apr. 2023, Injury, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Revision surgery in a middle-aged patient with pertrochanteric fracture nonunion due to wedge effect caused by cephalomedullary nail: A case report.

  Takahiro Waki, Tomohiro Matsumura, Genta Fukumoto, Toshiharu Takami, Tomonori Yano, Kenjiro Ito, Shinji Matsushima, Tomoyuki Matsumoto, Ryosuke Kuroda

  Trochanteric femur fractures have traditionally been treated surgically with compression hip screws or cephalomedullary nails. With the increasing use of cephalomedullary nails, potential complications from this technique have surfaced. One of them is the potential for varus malreduction of trochanteric femur fractures, known as the "wedge effect", which is the distraction of fracture fragments generated during reamer and nail passage resulting in varus malalignment at the neck-shaft angle. Although trochanteric nonunion in the non-elderly is exceedingly rare, we experienced one such case after nailing due to the wedge effect that was subsequently successfully treated with a compression hip screw without bone grafting. Therefore, in the case of stable pertrochanteric fractures (AO/OTA 31A1) in younger patients, compression hip screw surgery may be the better choice of initial surgery to avoid later nonunion.

  Apr. 2023, Trauma case reports, 44, 100785 - 100785, English, International magazine


• 【椎間板の基礎と臨床】椎間板変性とオートファジー

  由留部 崇, 武岡 由樹, 神田 裕太郎, 伊藤 雅明, 垣内 裕司, 辻本 龍, 黒田 良祐, 角谷 賢一朗

  Apr. 2023, 脊椎脊髄ジャーナル, 36(1) (1), 13 - 18


• 【人工関節における進歩】手術支援技術 ナビゲーション 簡易ナビゲーション 人工股関節全置換術における簡易ナビゲーションの有用性

  林 申也, 黒田, 雄一, 中野 直樹, 松本 知之, 黒田 良祐

  Apr. 2023, 別冊整形外科, (83) (83), 139 - 142, Japanese


• 偽関節治療の基礎研究と臨床応用

  新倉 隆宏, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Apr. 2023, 日本整形外科学会雑誌, 97(4) (4), 252 - 260, Japanese


• 超音波治療の世界(基礎と臨床) LIPUSによる骨折治癒促進

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本超音波医学会, Apr. 2023, 超音波医学, 50(Suppl.) (Suppl.), S376 - S376, Japanese


• LIPUSのinduced membrane由来細胞に対する骨分化・血管新生促進効果の検討

  高瀬 恭平, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 山本 裕也, 西田 亮太, 黒田 良祐

  (一社)日本移植学会, Apr. 2023, 移植, 57(4) (4), 357 - 357, Japanese


• 偽関節治療の基礎研究と臨床応用

  新倉 隆宏, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Apr. 2023, 日本整形外科学会雑誌, 97(4) (4), 252 - 260, Japanese


• Exosomes derived from synovial fibroblasts from patients with rheumatoid arthritis promote macrophage migration that can be suppressed by miR-124-3p.

  Yuji Nakamachi, Kenichi Uto, Shinya Hayashi, Takaichi Okano, Akio Morinobu, Ryosuke Kuroda, Seiji Kawano, Jun Saegusa

  OBJECTIVES: Exosomes are potent vehicles for intercellular communication. Rheumatoid arthritis (RA) is a chronic systemic disease of unknown etiology. Local administration of miR-124 precursor to rats with adjuvant-induced arthritis suppresses systemic arthritis and bone destruction. Thus, exosomes may be involved in this disease. We aimed to determine the role of exosomes in the pathology of RA. METHODS: Fibroblast-like synoviocytes (FLS) were collected from patients with RA and osteoarthritis (OA). miR-124-3p mimic was transfected into the RA FLS (RA miR-124 FLS). Exosomes were collected from the culture medium by ultracentrifugation. Macrophages were produced from THP-1 cells. MicroRNAs in the exosomes were analyzed using real-time PCR. Proteomics analysis was performed using nanoscale liquid chromatography-tandem mass spectrometry. Macrophage migration was evaluated using a Transwell migration assay. SiRNA was used to knockdown proteins of interest. RESULTS: MicroRNAs in the RA FLS, RA miR-124 FLS, and OA FLS exosomes were similar. Proteomics analysis revealed that pentraxin 3 (PTX3) levels were higher in RA FLS exosomes than in RA miR-124 FLS and OA FLS exosomes, and proteasome 20S subunit beta 5 (PSMB5) levels were lower in RA FLS exosomes than in RA miR-124 FLS and OA FLS exosomes. The RA FLS exosomes promoted and the RA miR-124 FLS exosomes suppressed macrophage migration. PTX3-silenced RA FLS exosomes suppressed and PSMB5-silenced OA FLS exosomes promoted macrophage migration. CONCLUSIONS: RA FLS exosomes promote macrophage migration via PTX3 and PSMB5, and miR-124-3p suppresses this migration.

  Apr. 2023, Heliyon, 9(4) (4), e14986, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Fibrin clot and Leukocyte-rich platelet-rich fibrin show similar release kinetics and amount of growth factors: a pilot study.

  Yuta Nakanishi, Takehiko Matsushita, Kanto Nagai, Daisuke Araki, Yuichi Hoshino, Ryosuke Kuroda

  BACKGROUND: In knee arthroscopic surgery, fibrin clot (FC) and leukocyte-rich platelet-rich fibrin (L-PRF) may be used in augmentation for meniscal repair. Studies have investigated growth factors released from FC and L-PRF; however, it is difficult to compare FC and L-PRF between different studies. Direct comparison of growth factors that may support meniscal healing released from FC and L-PRF may be beneficial in deciding whether to use FC or L-PRF. If no significant difference is seen, the surgeon may decide to use FC which is easier to prepare compared to L-PRF. The purpose of this pilot study is to investigate the release amount and pattern of basic fibroblast growth factor (bFGF), platelet-derived growth factor AB (PDGF-AB), transforming growth factor β1 (TGF-β1), vascular endothelial growth factor (VEGF), and stromal cell-derived factor 1 (SDF-1) from FC and L-PRF. METHOD: Twenty milliliters (ml) of whole blood was collected from each of the four volunteers. Ten milliliters of whole blood was allocated for preparation of FC and 10 ml for L-PRF. FC and L-PRF were separately placed in 5 ml of culture media. Five milliliters of the culture media was sampled and refilled at 15 min, 1 day, 3 days, 1 week and 2 weeks. The collected culture was used to quantify bFGF, PDGF-AB, TGF-β1, VEGF, and SDF-1 release by Enzyme-linked immune-sorbent assay (ELISA). Mann-Whitney U test was performed to assess significance of differences in amount of each growth factor released between FC and L-PRF. Significance was accepted at P value less than 0.05. RESULTS: At two weeks, the cumulative release of TGF-β1 was the highest among all the growth factors in both FC and L-PRF (FC:19,738.21 pg/ml, L-PRF: 16,229.79 pg/ml). PDGF-AB (FC: 2328 pg/ml, L-PRF 1513.57 pg/ml) had the second largest amount, followed by VEGF (FC: 702.06 pg/ml, L-PRF 595.99 pg/ml) and bFGF (FC: 23.48 pg/ml, L-PRF 18.2 pg/ml), which order was also common in both FC and L-PRF. No significant difference in final release amount and pattern was seen between FC and L-PRF. CONCLUSION: The current pilot study showed that cumulative release amount and release pattern of PDGF-AB, VEGF, TGF-β1, and bFGF did not significantly differ between FC and L-PRF during the two weeks of observation.

  Mar. 2023, Journal of orthopaedic surgery and research, 18(1) (1), 238 - 238, English, International magazine

  Scientific journal


• Separation Surgery and Postoperative Intensity-Modulated Radiation Therapy for a High-Grade Myxofibrosarcoma Involving the Spine: A Case Report.

  Yutaro Kanda, Takashi Yurube, Ryosuke Kuroda, Kenichiro Kakutani

  BACKGROUND Myxofibrosarcoma involving the spine is a rare and intractable disease. Although wide surgical resection is the mainstay of treatment, it is often difficult to complete marginal en-bloc resection due to adjacent neurovascular components in the spine. Separation surgery, a partial resection to achieve circumferential separation and high-dose irradiation such as postoperative intensity-modulated radiation therapy, has received much attention as a new therapy for spinal tumors. However, little evidence regarding separation surgery with intensity-modulated radiation therapy for a spinal myxofibrosarcoma exists. CASE REPORT We present a case of a 75-year-old man with progressive myelopathy. Radiological examination revealed severe spinal cord compression due to an unknown widespread multiple tumor in the cervical and thoracic spine. Computed tomography-guided biopsy showed high-grade sarcoma. Positron emission tomography detected no other tumors in the body. Separation surgery was therefore performed with posterior stabilization. Hematoxylin and eosin staining showed storiform cellular infiltrates and pleomorphic cell nuclei. Histopathology identified high-grade myxofibrosarcoma. Postoperative intensity-modulated radiation therapy of 60 Gy in 25 fractions was completed without any adverse effects. The patient had greatly improved neurological function, was capable of walking with a cane, and had no recurrence for at least 1 year after surgery. CONCLUSIONS We reported a case of an unresectable high-grade myxofibrosarcoma of the spine successfully treated with the combination of separation surgery and postoperative intensity-modulated radiation therapy. This combination therapy is a relatively safe and effective treatment option in patients with impending neurological damage by unresectable sarcomas when total en-bloc resection is challenging due to the size, location, or adhesion.

  Mar. 2023, The American journal of case reports, 24, e939368, English, International magazine

  Scientific journal


• 発育性股関節形成不全と無症候性股関節の放射線画像における骨形態の比較検討

  立花 章太郎, 黒田 雄一, 齊藤 昌愛, 林 申也, 藤田 雅広, 菊池 健一, 生田 健明, 安喰 健祐, 尾ノ井 勇磨, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(2) (2), S113 - S113, Japanese


• 本邦における骨盤発生悪性骨・軟部腫瘍の臨床成績と予後因子の検討

  竹森 俊幸, 河本 旭哉, 藤田 郁夫, 藤本 卓也, 原 仁美, 深瀬 直政, 澤田 良子, 藤原 周一, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S957 - S957, Japanese


• メッシュプレートを用いて内固定を行った母趾基節骨偽関節の2例

  大野 裕也, 福井 友章, 大江 啓介, 澤内 健一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2023, 中部日本整形外科災害外科学会雑誌, 66(春季学会) (春季学会), 289 - 289, Japanese


• 骨SPECT/CTにおける偽関節モデルファントムを用いた金属インプラントのCT減弱補正に関する研究

  大江 啓介, 福井 友章, 澤内 健一, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1024 - S1024, Japanese


• ここまできた!骨・軟骨再生医療の最前線 偽関節患者に対する自家末梢血CD34陽性細胞移植による骨・血管再生医療

  大江 啓介, 新倉 隆宏, 福井 友章, 澤内 健一, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1072 - S1072, Japanese


• 四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1082 - S1082, Japanese


• 患者立脚型QOL評価を用いた大腿骨および脛骨偽関節の術後成績の検討

  福井 友章, 新倉 隆宏, 大江 啓介, 澤内 健一, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1082 - S1082, Japanese


• 脛骨慢性骨髄炎病的骨折に対しCLAPを併用し骨接合術と遊離皮弁術を同時に行った1例

  牟田口 由紀子, 澤内 健一, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2023, 中部日本整形外科災害外科学会雑誌, 66(2) (2), 334 - 335, Japanese


• 疫学1:RA/関節型JIAの治療 高齢関節リウマチ患者における疾患活動性の年次変化に関する検討 関西多施設共同研究ANSWER Cohort study

  山田 啓貴, 神野 定男, 前田 俊恒, 林 申也, 山本 渉, 大西 輝, 鬼澤 秀夫, 武内 徹, 平松 ゆり, 沖田 康孝, 蛯名 耕介, 孫 瑛洙, 吉田 直史, 渡部 龍, 原 良太, 片山 昌紀, 山下 真依, 能瀬 洋子, 山本 譲, 岡野 隆一, 西村 啓佑, 上田 洋, 千藤 荘, 橋本 求, 黒田 良祐, 三枝 淳

  (一社)日本リウマチ学会, Mar. 2023, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 526 - 526, Japanese


• JAK阻害薬-2 JAK阻害薬4剤の有効性比較と有効性に影響を与える因子の探索 関西多施設ANSWERコホートによる解析

  林 申也, 前田 俊恒, 山下 真依, 白杉 郁, 山本 譲, 山田 啓貴, 岡野 隆一, 西村 啓佑, 上田 洋, 神野 定男, 三枝 淳, 山本 渉, 村田 浩一, 藤井 貴之, 秦 健一郎, 吉川 紋佳, 蛯名 耕介, 惠谷 悠紀, 吉田 直史, 安室 秀樹, 原 良太, 片山 昌紀, 橋本 求, 岡野 匡志, 立花 章太郎, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2023, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 551 - 551, Japanese


• 足趾に生じた粘液型脂肪肉腫の一例

  宮本 智弘, 藤原 周一, 原 仁美, 深瀬 直政, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2023, 中部日本整形外科災害外科学会雑誌, 66(春季学会) (春季学会), 305 - 305, Japanese


• Nonunion of Hoffa Fracture Successfully Treated by Total Knee Arthroplasty: A Case Report.

  Toshiki Kitamura, Tomoaki Fukui, Tomoyuki Matsumoto, Keisuke Oe, Kenichi Sawauchi, Ryosuke Kuroda, Takahiro Niikura

  A Hoffa fracture is a rare type of femoral fracture that is difficult to treat. Nonoperative treatments usually result in failure; hence, in most cases, surgical treatments are essential. Nonunion following Hoffa fracture appears to be relatively uncommon, and there are limited reports in the literature about this type of nonunion. These reports suggest that open reduction and rigid internal fixation is the standard treatment for this type of nonunion. This study reports the case of a 61-year-old male patient who suffered from left lateral Hoffa fracture after falling from a truck bed. At the former hospital, open reduction and internal fixation were performed with plates and screws at 8 days post-injury. Postoperatively, displacement of the lateral proximal fragment was observed, and the patient reported left knee pain. Therefore, a revision open reduction and internal fixation was performed 4 months post-surgery. However, 6 months after the revision surgery, the patient reported instability and pain in the left knee, and subsequent radiography revealed nonunion of the fracture in the lateral condyle. The patient was referred to our hospital for further treatment. Treatment by re-revision open reduction and internal fixation was deemed challenging, and so rotating hinge knee (RHK) arthroplasty was performed as a salvage treatment. At 3 years post-surgery, no significant problems were observed, and the patient could walk without any assistance. The range of motion of the left knee was 0 to 100° without extension lag, and there was no lateral instability. Standard treatment for Hoffa fracture nonunion is commonly anatomical reduction and rigid internal fixation. However, total knee arthroplasty may be a better option for the treatment of Hoffa fracture nonunion in older patients.

  Mar. 2023, Cureus, 15(3) (3), e35780, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 骨SPECT/CTにおける偽関節モデルファントムを用いた金属インプラントのCT減弱補正に関する研究

  大江 啓介, 福井 友章, 澤内 健一, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1024 - S1024, Japanese


• ここまできた!骨・軟骨再生医療の最前線 偽関節患者に対する自家末梢血CD34陽性細胞移植による骨・血管再生医療

  大江 啓介, 新倉 隆宏, 福井 友章, 澤内 健一, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1072 - S1072, Japanese


• 四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1082 - S1082, Japanese


• 患者立脚型QOL評価を用いた大腿骨および脛骨偽関節の術後成績の検討

  福井 友章, 新倉 隆宏, 大江 啓介, 澤内 健一, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1082 - S1082, Japanese


• メッシュプレートを用いて内固定を行った母趾基節骨偽関節の2例

  大野 裕也, 福井 友章, 大江 啓介, 澤内 健一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2023, 中部日本整形外科災害外科学会雑誌, 66(春季学会) (春季学会), 289 - 289, Japanese


• JAK阻害薬-4 tsDMARDsとbDMARDsにより関節リウマチ患者の非炎症性疼痛へ及ぼす効果の比較 関西多施設共同研究ANSWER Cohortを用いた検討

  山下 真依, 岡野 隆一, 白杉 郁, 山田 啓貴, 西村 啓佑, 千藤 荘, 上田 洋, 前田 俊恒, 林 申也, 山本 渉, 大西 輝, 村上 孝作, 斯波 秀行, 秦 健一郎, 辻本 考平, 蛯名 耕介, 孫 瑛洙, 吉田 直史, 原 良太, 渡部 龍, 橋本 求, 黒田 良祐, 三枝 淳

  (一社)日本リウマチ学会, Mar. 2023, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 621 - 621, Japanese


• 脊椎転移術後創離開のリスク因子の検討と予防のための新たな試み Curved skin incision

  宮崎 邦彦, 神田 裕太郎, 武岡 由樹, 張 鍾穎, 由留部 崇, 大西 洋輝, 松尾 智哉, 劉 正夫, 秋末 敏宏, 黒田 良祐, 角谷 賢一朗

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(2) (2), S289 - S289, Japanese


• 本邦における骨盤発生悪性骨・軟部腫瘍の臨床成績と予後因子の検討

  竹森 俊幸, 河本 旭哉, 藤田 郁夫, 藤本 卓也, 原 仁美, 深瀬 直政, 澤田 良子, 藤原 周一, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S957 - S957, Japanese


• 足趾に生じた粘液型脂肪肉腫の一例

  宮本 智弘, 藤原 周一, 原 仁美, 深瀬 直政, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2023, 中部日本整形外科災害外科学会雑誌, 66(春季学会) (春季学会), 305 - 305, Japanese


• 軟部腫瘍に対するホウ素中性子捕捉療法の適応の判断 明細胞肉腫とcutaneous melanocytoma with CRTC1-TRIM11 fusion例から

  藤本 卓也, 鈴木 実, 神谷 伸彦, 渡部 直史, 藤田 郁夫, 後村 大祐, 竹森 俊幸, 河本 旭哉, 秋末 敏宏, 黒田 良祐, 廣瀬 隆則

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S833 - S833, Japanese


• 生物学的製剤 IL-6阻害薬は骨びらんによる関節破壊の進行を優位に抑制する

  林 申也, 松原 司, 前田 俊恒, 福田 康治, 舟橋 恵子, 橋本 麿和, 積山 賢, 立花 章太郎, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2023, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 603 - 603, Japanese


• JAK阻害薬-7 多剤耐性マーカーMDR1遺伝子がJAK阻害薬の治療効果に与える影響について

  尾ノ井 勇磨, 菊池 健一, 前田 俊恒, 林 申也, 安喰 健祐, 生田 健明, 立花 章太郎, 橋本 麿和, 積山 賢, 舟橋 恵子, 福田 康治, 黒田 良祐, 松原 司

  (一社)日本リウマチ学会, Mar. 2023, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 708 - 708, Japanese


• IL-6刺激下でのJAK阻害剤の血管新生抑制効果の比較検討

  安喰 健祐, 林 申也, 前田 俊恒, 菊池 健一, 藤田 雅広, 生田 健明, 尾ノ井 勇磨, 立花 章太郎, 福田 康治, 積山 賢, 橋本 麿和, 舟橋 恵子, 黒田 良祐, 松原 司

  (一社)日本リウマチ学会, Mar. 2023, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 774 - 774, Japanese


• RA患者由来線維芽細胞様滑膜細胞へのIL-6・TNFα刺激に対するJAK阻害剤の炎症抑制効果の比較検討

  生田 健明, 林 申也, 前田 俊恒, 菊池 健一, 藤田 雅広, 安喰 健祐, 尾ノ井 勇磨, 立花 章太郎, 福田 康治, 積山 賢, 橋本 麿和, 舟橋 恵子, 黒田 良祐, 松原 司

  (一社)日本リウマチ学会, Mar. 2023, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 873 - 873, Japanese


• 軟骨細胞へのIL-6刺激に対するJAK阻害剤の効果

  立花 章太郎, 林 申也, 前田 俊恒, 菊池 健一, 藤田 雅広, 安喰 健祐, 生田 健明, 尾ノ井 勇磨, 福田 康治, 積山 賢, 橋本 麿和, 舟橋 恵子, 黒田 良祐, 松原 司

  (一社)日本リウマチ学会, Mar. 2023, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 873 - 873, Japanese


• Foveal Triangular Fibrocartilage Complex Tear Repair with Nonabsorbent Suture Tape.

  Issei Shinohara, Atsuyuki Inui, Yutaka Mifune, Kohei Yamaura, Shintaro Mukohara, Ryosuke Kuroda

  PURPOSE: Arthroscopic repair is performed for fovea injuries of the triangular fibrocartilage complex (TFCC) when instability of the distal radioulnar joint results in pain, decreased grip strength, and mechanical symptoms. During TFCC repair, reconstruction of its attachment to the fovea is important. Nonabsorbent suture tapes have gained attention for ligament repair in the trapeziometacarpal joint, scapholunate ligament, and thumb metacarpophalangeal ligament. However, there are no reports of TFCC repair using suture tapes. We evaluated the early postoperative results of this approach. METHODS: Participants underwent arthroscopic suture tape repair of foveal TFCC tears and were observed for more than 1 year. All repairs were performed using suture tapes and an outside-in technique with a bone tunnel from the ulnar shaft to the fovea. The postoperative complications, postoperative wrist range of motion, grip strength, and the Modified Mayo Score were evaluated. RESULTS: Arthroscopic repair with a suture tape was performed for 20 hands using the outside-in technique. The ranges of motion for the operated and nonoperated hands were comparable 1 year after surgery (pronation, 84° ± 4°; supination, 83° ± 4°). The mean grip strength improved from 65% ± 13% before surgery to 89% ± 9% after a year. The mean Modified Mayo Score improved from 58 ± 11 before surgery to 91 ± 8 after a year. Postoperative complications included abnormal sensation of the dorsal ulnar side in 2 hands. CONCLUSIONS: After using a suture tape to attach the TFCC to the fovea, satisfactory function was achieved in the early postoperative period with grip strength restoration. For the repair of foveal TFCC tears, attachment to the ulnar fovea is important, and repair by a suture tape may be useful. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.

  Feb. 2023, The Journal of hand surgery, English, International magazine

  Scientific journal


• Screening for Osteoporosis from Blood Test Data in Elderly Women Using a Machine Learning Approach.

  Atsuyuki Inui, Hanako Nishimoto, Yutaka Mifune, Tomoya Yoshikawa, Issei Shinohara, Takahiro Furukawa, Tatsuo Kato, Shuya Tanaka, Masaya Kusunose, Ryosuke Kuroda

  The diagnosis of osteoporosis is made by measuring bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA). Machine learning, one of the artificial intelligence methods, was used to predict low BMD without using DXA in elderly women. Medical records from 2541 females who visited the osteoporosis clinic were used in this study. As hyperparameters for machine learning, patient age, body mass index (BMI), and blood test data were used. As machine learning models, logistic regression, decision tree, random forest, gradient boosting trees, and lightGBM were used. Each model was trained to classify and predict low-BMD patients. The model performance was compared using a confusion matrix. The accuracy of each trained model was 0.772 in logistic regression, 0.739 in the decision tree, 0.775 in the random forest, 0.800 in gradient boosting, and 0.834 in lightGBM. The area under the curve (AUC) was 0.595 in the decision tree, 0.673 in logistic regression, 0.699 in the random forest, 0.840 in gradient boosting, and 0.961, which was the highest, in the lightGBM model. Important features were BMI, age, and the number of platelets. Shapley additive explanation scores in the lightGBM model showed that BMI, age, and ALT were ranked as important features. Among several machine learning models, the lightGBM model showed the best performance in the present research.

  Feb. 2023, Bioengineering (Basel, Switzerland), 10(3) (3), English, International magazine

  Scientific journal


• The Identification of Risk Factors for Symptomatic Spinal Metastasis Onset: A Prospective Cohort Study of 128 Asymptomatic Spinal Metastasis Patients.

  Kenichiro Kakutani, Yutaro Kanda, Takashi Yurube, Yoshiki Takeoka, Kunihiko Miyazaki, Hiroki Ohnishi, Tomoya Matsuo, Masao Ryu, Kohei Kuroshima, Naotoshi Kumagai, Yoshiaki Hiranaka, Shinya Hayashi, Yuichi Hoshino, Hitomi Hara, Yoshitada Sakai, Ryosuke Kuroda

  Background: Symptomatic spinal metastasis (SSM) decreases the activities of daily living (ADL) and quality of life of cancer patients. However, the risk factors for SSM onset remain unclear. This prospective cohort study aimed to statistically analyze the significant risk factors. Methods: From 2016 to 2018, 210 consecutive patients with spinal metastases were prospectively registered. Patients with SSM at the first consultation and those who were unable to be followed-up owing to poor general condition were excluded. The demographic factors (age, sex, primary cancer, performance status, and ADL), clinical factors (radiation therapy, chemotherapy, molecularly targeted drugs, and bone-modifying agents (BMAs)), and Spinal Neoplastic Instability Score (SINS) were evaluated. Multivariate analysis was performed to identify the risk factors for SSM onset. Furthermore, the threshold was calculated from the receiver operating characteristic curve using the Youden index. Results: Thirty-nine patients who presented with SSM at the first consultation and 43 patients who were unable to be followed-up owing to poor general condition were excluded. Finally, 128 asymptomatic patients were included. Thirty-seven patients (28.9%) developed SSM during the follow-up period. The total SINS (OR: 1.739; 95% CI: 1.345-2.250) was identified as the most significant factor. The cut-off value of the SINS was 9.5 (sensitivity: 67.6%; specificity: 83.5%). Twenty-five (62.5%) of the forty patients with a SINS ≥ 10 developed SSM within a mean of 5.5 months (95% CI: 1.17-9.83). Furthermore, all patients with a SINS ≥ 13 developed SSM (n = 5) within a mean of 1.37 months (95% CI: 0.0-3.01). Conclusions: This study identified the significant risk factors for SSM onset and the threshold of the SINS. If long-term survival is expected, patients with a SINS ≥ 10 should be considered for intervention to prevent SSM.

  Feb. 2023, Cancers, 15(4) (4), English, International magazine

  Scientific journal


• Degree of Accuracy With Which Deep Learning for Ultrasound Images Identifies Osteochondritis Dissecans of the Humeral Capitellum.

  Issei Shinohara, Tomoya Yoshikawa, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Shintaro Mukohara, Tatsuo Kato, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Medical screening using ultrasonography (US) has been performed on young baseball players for early detection of osteochondritis dissecans (OCD) of the humeral capitellum. Deep learning (DL) and artificial intelligence (AI) techniques are widely adopted in the medical imaging research field. PURPOSE/HYPOTHESIS: The purpose of this study was to calculate the diagnostic accuracy using DL for US images of OCD. We hypothesized that using DL for US imaging would improve the prediction accuracy of OCD. STUDY DESIGN: Cohort study (Diagnosis); Level of evidence, 2. METHODS: A total of 40 elbows (mean age of patients, 12.1 years) that were suspected of having OCD at a medical checkup and later confirmed by radiographs and magnetic resonance imaging were included in the study. The affected elbows were used as the OCD group and the contralateral elbows as the control group. From US videos, 100 images per elbow were captured from different angles, and 4000 images of the elbows were prepared for both groups. Of these, 80% were randomly selected by DL models and used as training data; the remaining were used as test data. Transfer learning was conducted using 3 pretrained DL models. The confusion matrix and the area under the receiver operating characteristic curve (AUC) were used to evaluate the model, and the visualization of the areas deemed important by the DL models was also performed. Furthermore, OCD regions were detected using an automatic image recognition model based on DL. RESULTS: Classification of the OCD image by the DL model was performed; the best accuracy score was 0.87; the recall was 1.00. AUC was high for all DL models. Visualization of important features showed that AI predicted the presence of OCD by focusing on the irregularity or discontinuity of the surface of subchondral bone. In the detection of OCD task, the mean average precision was 0.83. CONCLUSION: The DL on US images identified OCD with high accuracy. The important features detected by the DL models correspond to the areas used by clinicians in screening the US images. The OCD was also detected with high accuracy using the object detection model. The AI model may be used in medical screening for OCD.

  Feb. 2023, The American journal of sports medicine, 51(2) (2), 358 - 366, English, International magazine

  Scientific journal


• Total knee arthroplasty for severe valgus deformity of the knee with extra-articular deformities of the femur and tibia using a 3-dimensional image matching software system.

  Kemmei Ikuta, Tomoyuki Matsumoto, Naoki Nakano, Shintaro Mukohara, Shinya Hayashi, Ryosuke Kuroda

  INTRODUCTION AND IMPORTANCE: Knee osteoarthritis with femoral and/or tibial extra-articular deformities makes total knee arthroplasty (TKA) technically difficult to perform, especially using intramedullary-based instrumentation systems. The Athena Knee 3-dimensional (3-D) image matching software is effective for TKA with an extra-articular deformity, especially in case of using a long-stem prosthesis or not available computer-assisted navigation systems. CASE PRESENTATION: A 79-year-old woman presented with right knee pain secondary to a progressive valgus deformity and gait disturbance. She had experienced a supracondylar femoral fracture fifteen years ago, and a tibial shaft fracture ten years ago on the same side; both of fractures were treated surgically. She had a severe valgus knee deformity and extra-articular deformity of femur and tibia, and valgus stress test detected medial knee instability. The range of motion was 0° in extension and 75° in flexion. Severe medial knee laxity compelled us to use a constrained and long-stem prosthesis, resulting in the use of an intramedullary guided system. The 3-D software system helped us to determine the amount of bone to cut as well as the appropriate entry points for the intramedullary rods and mechanical axis restoration. At two years after surgery, knee range of motion improved to 90° in flexion, and walking ability had also advanced from the use of two crutches to that of a T cane. CONCLUSION: The 3-D image matching software system for preoperative planning was useful for TKA with extra-articular deformity, especially in the case of a long-stem prosthesis without using a navigation system.

  Feb. 2023, International journal of surgery case reports, 103, 107853 - 107853, English, International magazine


• The efficiency of genetically modified mesenchymal stromal cells combined with a functionally graded scaffold for bone regeneration in corticosteroid-induced osteonecrosis of the femoral head in rabbits.

  Masanori Tsubosaka, Masahiro Maruyama, Elaine Lui, Seyedsina Moeinzadeh, Elijah Ejun Huang, Junichi Kushioka, Hirohito Hirata, Charu Jain, Hunter W Storaci, Calvin Chan, Masakazu Toya, Qi Gao, Victoria Teissier, Huaishuang Shen, Xueping Li, Ning Zhang, Tomoyuki Matsumoto, Ryosuke Kuroda, Stuart B Goodman, Yunzhi Peter Yang

  Core decompression (CD) with mesenchymal stromal cells (MSCs) is an effective therapy for early-stage osteonecrosis of the femoral head (ONFH). Preconditioning of MSCs, using inflammatory mediators, is widely used in immunology and various cell therapies. We developed a three-dimensional printed functionally graded scaffold (FGS), made of β-TCP and PCL, for cell delivery at a specific location. The present study examined the efficacy of CD treatments with genetically modified (GM) MSCs over-expressing PDGF-BB (PDGF-MSCs) or GM MSCs co-over-expressing IL-4 and PDGF-BB and preconditioned for three days of exposure to lipopolysaccharide and tumor necrosis factor-alpha (IL-4-PDGF-pMSCs) using the FGS for treating steroid-induced ONFH in rabbits. We compared CD without cell-therapy, with IL-4-PDGF-pMSCs alone, and with FGS loaded with PDGF-MSCs or IL-4-PDGF-pMSCs. For the area inside the CD, the bone volume in the CD alone was higher than in both FGS groups. The IL-4-PDGF-pMSCs alone and FGS + PDGF-MSCs reduced the occurrence of empty lacunae and improved osteoclastogenesis. There was no significant difference in angiogenesis among the four groups. The combined effect of GM MSCs or pMSCs and the FGS was not superior to the effect of each alone. To establish an important adjunctive therapy for CD for early ONFH in the future, it is necessary and essential to develop an FGS that delivers biologics appropriately and provides structural and mechanical support.

  Jan. 2023, Journal of biomedical materials research. Part A, 111(8) (8), 1120 - 1134, English, International magazine

  Scientific journal


• Anatomical Assessment of Cephalic Vein and Superficial Branch of Radial Nerve Using High-Resolution Ultrasound Imaging

  Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Shintaro Mukouhara, Tomoya Yoshikawa, Ryosuke Kuroda

  Elsevier BV, 2023, Journal of Hand and Microsurgery, 15(1) (1), 41 - 44

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The Combination of Separation Surgery and Intensity Modulated Radiation Therapy (IMRT) for a Primary Osteosarcoma of the Spine: A Case Report and Literature Review.

  Yutaro Kanda, Yuji Kakiuchi, Takashi Yurube, Yoshiki Takeoka, Kunihiko Miyazaki, Ryosuke Kuroda, Kenichiro Kakutani

  BACKGROUND: Primary spinal osteosarcoma is a rare and intractable disease. Although en bloc resection is favorable for longer survival, it is not always achievable. Separation surgery, a partial resection with circumferential separation to safely deliver high-dose irradiation including intensity-modulated radiation therapy (IMRT), has been recently indicated for patients with spinal cord compression secondary to solid tumor metastases. However, little evidence regarding this combination approach to spinal osteosarcoma exists. CASE PRESENTATION: We report a 55-year-old male patient with a T1 tumor who underwent urgent decompression surgery for epidural spinal cord compression. Pathological findings revealed primary osteosarcoma. Separation surgery, IMRT, and adjuvant chemotherapy were applied to reduce the symptoms of epidural spinal cord compression. The patient was alive without local recurrence at the 5-year follow-up. CONCLUSIONS: Separation surgery with IMRT can be a relatively safe and effective treatment option in patients with osteosarcoma adjacent to spinal cord when en-bloc resection is challenging.

  2023, Clinical medicine insights. Case reports, 16, 11795476231171891 - 11795476231171891, English, International magazine


• Clinical and Radiological Comparison of Single and Double Intra-articular Injection of Adipose-Derived Stromal Vascular Fraction for Knee Osteoarthritis.

  Masahiro Fujita, Tomoyuki Matsumoto, Satoshi Sobajima, Masanori Tsubosaka, Takehiko Matsushita, Hideki Iwaguro, Ryosuke Kuroda

  The aim of the article is to compare the clinical and radiological outcomes between single and double stromal vascular fraction (SVF) cell injections in patients with knee osteoarthritis (OA). We included 54 patients treated for varus knee OA with intra-articular SVF cell injection. They were divided into two groups: those who received one injection and those who received two. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, knee range of motion, and knee muscle force were assessed at baseline and 3, 6, 12, and 24 months after the first injection. The preoperative hip-knee-ankle (HKA) angle was evaluated using plain radiographs, and T2 mapping values were assessed. The total WOMAC score improved significantly in the single injection group from 3 to 24 months, but the total WOMAC score in the double injection group improved significantly at 24 months. The T2 mapping values in both the groups improved, with a significant difference at 12 months. The preoperative mean HKA angle and the correlation coefficients between the HKA angle and the total WOMAC score and between the HKA angle and the T2 mapping value of the medial femur were significant. In conclusion, double injections may provide more satisfactory treatment outcomes in patients with severe varus knee alignment. This clinical trial is registered in the Japanese Ministry of Health, Labour and Welfare (URL: https://saiseiiryo.mhlw.go.jp/published_plan/index/2) with the registration name "Cell transplantation therapy for osteoarthritis using autologous subcutaneous adipose tissue-derived regenerative (stem) cells (ADRCs)," and the registration number was "PB5160012."

  2023, Cell transplantation, 32, 9636897231190175 - 9636897231190175, English, International magazine

  Scientific journal


• Current development in surgical techniques, graft selection and additional procedures for anterior cruciate ligament injury: a path towards anatomic restoration and improved clinical outcomes-a narrative review.

  Koji Nukuto, Yuichi Hoshino, Kiminari Kataoka, Ryosuke Kuroda

  BACKGROUND AND OBJECTIVE: Anterior cruciate ligament (ACL) reconstruction has been widely used for ACL injury for a long time. However, residual rotational instability and osteoarthritic changes after ACL reconstruction have been identified as problems. Thus, anatomic reconstruction techniques, various types of grafts and additional procedures have been desired to improve the clinical outcomes and knee instability. Although clinical outcomes and knee stability are better than in the past, ipsilateral graft failures still occur in 4-17% and osteoarthritic changes are seen in about 20% of patients after ACL reconstruction. To remedy these problems, it is necessary to improve the understanding of various surgical techniques and grafts and to pursue further improvement of surgical techniques. Therefore, the objective of this review is to summarize the advantages and disadvantages of various surgical techniques and graft selection, and additional procedures for ACL injury. METHODS: A literature review was conducted on the surgical procedures for ACL injury. Recent trends in surgical techniques, graft selection, and additional procedures for ACL injury were described. We performed a literature search in PubMed for studies published from origin to May 8, 2023. Studies were required to be English-language articles. KEY CONTENT AND FINDINGS: Although many reports indicate that double-bundle ACL reconstruction is comparable to anatomic single-bundle (SB) reconstruction, intraoperative complications such as tunnel coalition exist in double-bundle reconstruction, and the technique needs to be improved. ACL repair has shown good short-term results, but long-term results need to be examined in the future. Quadriceps tendon autograft is being used more frequently, but hamstrings tendon autograft and bone-patellar tendon-bone autograft also have good results. In addition, in higher-risk cases, lateral extra-articular tenodesis (LET) and anterolateral ligament (ALL) reconstruction can be performed with good results. CONCLUSIONS: To further improve clinical outcomes, more anatomical reconstructions should be pursued. Autografts are better than allografts and synthetic grafts, but further study is needed to determine which graft is better. Additional procedures should be performed in highly unstable cases and in revision cases.

  2023, Annals of joint, 8, 39 - 39, English, International magazine

  Scientific journal


• 軟骨肉腫との鑑別を要した骨盤軟骨粘液線維腫の1例

  山本 顕, 藤原 周一, 河本 旭哉, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Jan. 2023, 中部日本整形外科災害外科学会雑誌, 66(1) (1), 101 - 102, Japanese


• 膝前十字靱帯再建術後の膝伸展筋力回復を予測する予測スコアの開発および検証

  上田 雄也, 松下 雄彦, 柴田 洋平, 三浦 大祐, 瀧口 耕平, 木田 晃弘, 小野 くみ子, 小野 玲, 長井 寛斗, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (一社)兵庫県理学療法士会, Dec. 2022, 理学療法兵庫, (28) (28), 43 - 44, Japanese


• Osteomyelitis of the Pubis Treated by Masquelet Technique in a Football Player: A Case Report.

  Hitomi Kitamura, Tomoaki Fukui, Keisuke Oe, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: Osteomyelitis pubis is a rare disease that presents with fever, pubic or hip pain, pain during hip movement, and claudication to avoid pain. It most frequently affects young athletes involved in sports that require twisting and cutting, but its exact cause is unknown and no definite treatment has been established. We report a case of pubic osteomyelitis in a young football player who was treated using the Masquelet technique and antibiotics with a good clinical course. CASE REPORTS: A 22-year-old male football player in a national-level university club team visited a nearby clinic complaining of high fever and mild pain in his bilateral hip joints. As a result of examination, we diagnosed osteomyelitis pubis and reconstructed the pubic symphysis by the Masquelet technique. In this case, the joint-like structure of the pubic symphysis was successfully reconstructed, and the patient was able to continue playing the sport. Three years and 3 months after surgery, he had no limitation of bilateral hip joint range of motion and did not display any symptoms while playing football. CONCLUSION: Masquelet technique could be a novel surgical method for managing osteomyelitis pubis, even in athletes.

  Dec. 2022, Journal of orthopaedic case reports, 12(12) (12), 39 - 42, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Outcomes of palliative surgery for bone metastasis of metastatic renal cell carcinoma in the era of targeted therapy.

  Hitomi Hara, Teruya Kawamoto, Naomasa Fukase, Ryoko Sawada, Shuichi Fujiwara, Shunsuke Yahiro, Tomohiro Miyamoto, Tomoaki Terakawa, Yutaka Mifune, Yuichi Hoshino, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue

  INTRODUCTION: The introduction of tyrosine kinase inhibitors has revolutionized treatment strategies for metastatic renal cell carcinoma (RCC) and has improved survival rates. The number of patients with bone metastases from RCC requiring surgery will increase as survival rates improve. However, there is insufficient evidence to standardize the treatment of bone metastases after the introduction of targeted therapy for metastatic RCC. We aimed to determine the outcomes of palliative surgical treatment of bone metastases in the extremities of patients with metastatic RCC. MATERIALS AND METHODS: We retrospectively reviewed 26 lesions from 17 patients who underwent surgery for extremity and acetabular bone metastases and were treated with targeted therapies for advanced RCC between 2008 and 2020. The median follow-up duration was 19 months (range, 4-76). We assessed the patients' activities of daily living, quality of life, and pain and analyzed their postoperative values relative to preoperative values. Postoperative overall survival (OS), local progression-free survival (LPFS), and the factors affecting them were evaluated using the Kaplan-Meier method and log-rank test. RESULTS: The 5-year OS and LPFS rates were 39.5% and 65.6%, respectively. The factors affecting OS were sex, Katagiri score, visceral metastases, and preoperative targeted therapy, while the factors affecting LPFS were pathologic fractures and surgical technique. CONCLUSION: In this study, the postoperative outcomes of palliative surgery for bone metastases from metastatic RCC were good. We suggest that systemic treatment should be prioritized over local control for advanced bone metastasis in RCC and surgery before pathological fracture should be performed for local control.

  Nov. 2022, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 49(5) (5), 928 - 933, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Influence of Metal Implants on Quantitative Evaluation of Bone Single-Photon Emission Computed Tomography/Computed Tomography.

  Keisuke Oe, Feibi Zeng, Takahiro Niikura, Tomoaki Fukui, Kenichi Sawauchi, Tomoyuki Matsumoto, Munenobu Nogami, Takamichi Murakami, Ryosuke Kuroda

  When visualizing biological activity at nonunion sites by the radioisotopes, gamma rays are more attenuated if metal implants are placed in the bone. However, the effects of various implant types and their placement on gamma ray attenuation in quantitative evaluation remain unknown. To elucidate these effects, we created a phantom that simulated the nonunion of the femur in this study. The count of gamma rays was measured by single-photon emission computed tomography/computed tomography (SPECT/CT) while considering CT-based attenuation correction (CTAC), metal implant placement, type (intramedullary nail or plate), and position. The count differed significantly with and without CTAC and with and without implants (both types) under CTAC. Significantly different counts were observed between the intramedullary nail and plate placed contralaterally to the lesion (i.e., non-lesion side). No significant difference was observed between the intramedullary nail and plate on the lesion side or between plates on the non-lesion and lesion sides. The measured standardized uptake value (SUV) was closer to the true SUV with CTAC than without. Moreover, the count was higher with implants than without. However, even with implants, it was lower than the actual count, indicating the absence of overcorrection. Implant type and position do not seem to influence the count.

  Nov. 2022, Journal of clinical medicine, 11(22) (22), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Human Non-Hypertrophic Nonunion Tissue Contains Osteoblast Lineage Cells and E-BMP-2 Activates Osteogenic and Chondrogenic Differentiation.

  Ryo Yoshikawa, Tomoaki Fukui, Keisuke Oe, Yohei Kumabe, Takahiro Oda, Kenichi Sawauchi, Kyohei Takase, Yuya Yamamoto, Yoshitada Sakai, Ryosuke Kuroda, Takahiro Niikura

  In this study, we examined the proliferation capability and osteogenic and chondrogenic differentiation potential of non-hypertrophic nonunion cells (NHNCs), and the effect of Escherichia coli-derived BMP-2 (E-BMP-2) on them. We enrolled five patients with non-hypertrophic nonunion. NHNCs isolated from nonunion tissue sampled during surgery were cultured, passaged, counted every 14 days, and analyzed. NHNCs were homogenous fibroblastic adherent cells and long-lived through at least 10 passages, with a slight decline. The cells were consistently positive for mesenchymal stem cell-related markers CD73 and CD105, and negative for the hematopoietic markers CD14 and CD45. NHNCs could differentiate into osteoblast lineage cells; however, they did not have strong calcification or sufficient chondrogenic differentiation capability. E-BMP-2 did not affect the proliferative capability of the cells but improved their osteogenic differentiation capability by increasing alkaline phosphatase activity and upregulating the gene expression of osterix, bone sialoprotein, and osteocalcin. E-BMP-2 enhanced their chondrogenic differentiation capability by upregulating the gene expression of aggrecan and collagen type II. We showed, for the first time, that NHNCs have the capacity to differentiate into osteoblast-lineage cells, although the chondrogenic differentiation potential was poor. Local application of E-BMP-2 with preservation of nonunion tissue is a potential treatment option for non-hypertrophic nonunion.

  Nov. 2022, Current issues in molecular biology, 44(11) (11), 5562 - 5578, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Identification and characterization of slow‑cycling cells in Ewing sarcoma.

  Shunsuke Yahiro, Teruya Kawamoto, Shuichi Fujiwara, Hitomi Hara, Naomasa Fukase, Ryoko Sawada, Toshiyuki Takemori, Tomohiro Miyamoto, Yutaka Mifune, Kenichiro Kakutani, Yuichi Hoshino, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Michiyo Koyanagi-Aoi, Takashi Aoi, Ryosuke Kuroda, Toshihiro Akisue

  Ewing sarcoma (ES) is an aggressive primary malignant bone tumor that predominantly affects children and young adults. Multimodal treatment approaches have markedly improved the survival of patients with localized ES. However, local recurrence and distant metastasis following curative therapies remain a main concern for patients with ES. Recent studies have suggested that slow‑cycling cells (SCCs) are associated with tumor progression, local recurrence and distant metastasis in various types of cancers. According to the results of these studies, it was hypothesized that SCCs may play a critical role in tumor progression, chemoresistance and local/distal recurrence in patients with ES. The present study applied a label‑retaining system using carboxyfluorescein diacetate succinimidyl ester (CFSE) to identify and isolate SCCs in ES cell lines. In addition, the properties of SCCs, including sphere formation ability, cell cycle distribution and chemoresistance, in comparison with non‑SCCs were investigated. RNA sequencing also revealed several upregulated genes in SCCs as compared with non‑SCCs; the identified genes not only inhibited cell cycle progression, but also promoted the malignant properties of SCCs. On the whole, the present study successfully identified SCCs in ES cells through a label‑retaining system using CFSE. Moreover, to the best of our knowledge, the present study is the first to describe the characteristic properties of SCCs in ES. The findings of this study, if confirmed, may prove to be useful in elucidating the underlying molecular mechanisms and identifying effective therapeutic targets for ES.

  Nov. 2022, International journal of oncology, 61(5) (5), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Comparison of the inhibitory effect of tocilizumab and etanercept on the progression of joint erosion in rheumatoid arthritis treatment.

  Shinya Hayashi, Tsukasa Matsubara, Toshihisa Maeda, Koji Fukuda, Keiko Funahashi, Marowa Hashimoto, Ken Tsumiyama, Tomoyuki Kamenaga, Yoshinori Takashima, Tomoyuki Matsumoto, Shotaro Tachibana, Ryosuke Kuroda

  We compared the efficacy of tocilizumab and etanercept in inhibiting radiographic progression of joint destruction in rheumatoid arthritis. Overall, 187 patients treated with etanercept or tocilizumab were selected. To adjust for baseline patient characteristics between the tocilizumab and etanercept treatment groups, a propensity score matching was performed. Radiographic progression of joint destruction was compared between patients treated with tocilizumab or etanercept. Clinical disease activity index (CDAI) and modified health assessment questionnaire (mHAQ) scores at the administration of biologic treatment and after 12 months of tocilizumab and etanercept therapy were measured and compared to radiographical parameters between the groups. Levels of C-reactive protein (CRP), matrix metalloproteinase-3 (MMP-3), CDAI, and mHAQ scores improved after 12 months of treatment in the two groups. Proportion of patients with no Sharp erosion score progression was significantly higher with tocilizumab treatment than with etanercept treatment (p = 0.032). Multivariate analysis demonstrated that Sharp erosion score was significantly associated with baseline CDAI (odds ratio, 1.05; 95% confidence interval, 1.003-1.099, p = 0.037). Tocilizumab treatment suppressed joint erosion progression compared to etanercept, and the progression correlated with baseline CDAI.

  Oct. 2022, Scientific reports, 12(1) (1), 17524 - 17524, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Development and Analysis of Mouse Medial Meniscus Posterior Root Tear Model

  Koji Nukuto, Takehiko Matsushita, Kohei Kamada, Kyohei Nishida, Kanto Nagai, Noriyuki Kanzaki, Yuichi Hoshino, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda

  Springer Science and Business Media LLC, Oct. 2022, Calcified Tissue International, 112(1) (1), 55 - 65

  Scientific journal


• Polyarthritis presented in a patient with untreated chronic hepatitis B infection

  Kenichi Kikuchi, Koji Fukuda, Shinya Hayashi, Toshihisa Maeda, Yoshinori Takashima, Masahiro Fujita, Kenmei Ikuta, Kensuke Anjiki, Shotaro Tachibana, Yuma Onoi, Tomoyuki Matsumoto, Ryosuke Kuroda, Tsukasa Matsubara

  ABSTRACT Hepatitis B virus (HBV) infection can cause arthritis, but it is rarely reported. In the current report, we present a case of chronic polyarthritis in a patient with untreated HBV infection. A 63-year-old woman suffering from polyarthritis in her fingers visited our institution. She had experienced exacerbations and remissions of polyarthritis for more than 20 years. She had been diagnosed with rheumatoid arthritis and had been treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and nonsteroidal anti-inflammatory drugs by her primary care doctor, but the csDMARDs were discontinued at the request of the patient 10 years before the first visit to our hospital. The blood test showed negative for rheumatoid factor and anticyclic citrullinated peptides antibody but positive for hepatitis B surface antigen. Hepatitis B surface antigen and HBV-Deoxyribo Nucleic Acid (DNA) were increased to 312.6 (IU/ml) and 4.6 (log copies/ml), respectively. Based on the results of abdominal computed tomography and echography, she was diagnosed with liver cirrhosis. Treatment for HBV infection was begun with oral tenofovir at 25 mg/day. The polyarthritis in her fingers gradually disappeared and has not relapsed for 6 months after the initiation of treatment for HBV infection. When polyarthritis is diagnosed, the possibility that chronic HBV infection can be one of the causes of polyarthritis should be considered.

  Oxford University Press (OUP), Oct. 2022, Modern Rheumatology Case Reports, 7(1) (1), 320 - 323

  Scientific journal


• 膝周囲骨切り術における膝伸展筋力の変化

  上田 雄也, 松下 雄彦, 柴田 洋平, 三浦 大祐, 瀧口 耕平, 長井 寛斗, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2022, 日本臨床スポーツ医学会誌, 30(4) (4), S212 - S212, Japanese


• 「空手道大会救護実践セミナー」開催における満足度・理解度調査と今後の課題

  峯山 佳恵, 上田 雄也, 島 稔樹, 元野 紘平, 高島 良典, 武岡 由樹, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2022, 日本臨床スポーツ医学会誌, 30(4) (4), S225 - S225, Japanese


• 脛骨病的骨折を生じた骨アミロイドーシスの一例

  山本 茜, 福井 友章, 大江 啓介, 新倉 隆宏, 澤内 健一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2022, 中部日本整形外科災害外科学会雑誌, 65(秋季学会) (秋季学会), 310 - 310, Japanese


• 軟骨肉腫との鑑別を要した骨盤軟骨粘液線維腫の一例

  山本 顕, 深瀬 直政, 河本 旭哉, 藤原 周一, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2022, 中部日本整形外科災害外科学会雑誌, 65(秋季学会) (秋季学会), 262 - 262, Japanese


• Effects of Femoral Component Design on the Deepest Point Position of the Trochlear Grove in Kinematically Aligned Total Knee Arthroplasty: A Comparison of Four Prothesis Designs

  Yoshinori Takashima, Naoki Nakano, Kazunari Ishida, Tomoyuki Kamenaga, Masanori Tsubosaka, Yuichi Kuroda, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  Abstract The aim of the study is to explore and compare the differences in trochlear shape and knee anatomy between four types of prostheses and preoperative native knee matched with preoperative computed tomography (CT). Thirty patients were scheduled for primary kinematically aligned total knee arthroplasty (TKA) for varus knee osteoarthritis at our hospital and the region between their pelvis to ankle joint was simulated using a CT-based three-dimensional planning software. The axial plane containing the transepicondylar axis was set as Slice A, and the 10-mm distal plane from Slice A was set as Slice B. The distances to the deepest trochlear groove between the native knee and each prosthesis and the medial and lateral facet heights were compared among the four groups. The deepest femoral trochlear groove of the prostheses was located 1.6 to 3.0 mm more medial than that of the native knee, and in the Persona group, it was significantly more medial than in the e-motion or Triathlon groups on both Slices A and B. The native knee and the medial and lateral facet heights of the four prostheses on both Slices A and B were significantly lower than those of preoperative native knees when femoral prostheses were set in the kinematically aligned (KA)-TKA position. The deepest point of the trochlear groove of the Persona group was the most medial among the four prostheses studied, and the deepest points differed depending on the prosthesis design in KA-TKA. Thus, surgeons should carefully select the type of prostheses used in KA-TKA.

  Georg Thieme Verlag KG, Sep. 2022, The Journal of Knee Surgery, 36(13) (13), 1316 - 1322

  Scientific journal


• The influence of stem alignment on the bone mineral density around the Polarstem following total hip arthroplasty

  Masahiro Fujita, Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Ryosuke Kuroda, Tomoyuki Matsumoto

  Springer Science and Business Media LLC, Sep. 2022, Archives of Orthopaedic and Trauma Surgery, 143(6) (6), 3621 - 3627

  Scientific journal


• Efficacy of Abductor Pollicis Longus Suspension Arthroplasty Combined With Mini TightRope for Osteoarthritis of Thumb Carpometacarpal Joint

  Kohei Yamaura, Atsuyuki Inui, Yutaka Mifune, Shintaro Mukohara, Takahiro Furukawa, Ryosuke Kuroda

  Background: We aimed to evaluate the efficacy of abductor pollicis longus (APL) suspension arthroplasty with trapeziectomy combined with first and second metacarpal fixation using suture button device. Methods: Thirteen patients (14 thumbs) who underwent APL suspension arthroplasty combined with suture button device for osteoarthritis of the carpometacarpal joint of the thumb (Eaton grade III: 6 and IV: 8 thumbs) at our institution between 2015 and 2019 and were followed up for more than 24 months were included in the study. Preoperative and postoperative range of motion (ROM) of radial and palmar abduction, grip and key pinch strength, visual analog scale (VAS) scores for pain, and the trapezial space ratio (TSR) on radiographic images before and after surgery were statistically examined. Results: The mean age of the patients was 59.6 ± 8.1 years, and the mean follow-up period was 45.4 ± 12.2 months. While grip and pinch strength did not significantly change between preoperative and final follow-up measurements, the ROM of radial and palmar abduction and the VAS score at the latest follow-up were significantly better than the preoperative values ( P < .05). The mean TSR immediately after surgery and at the latest follow-up was 0.28 ± 0.089 and 0.22 ± 0.084, respectively, indicating a mean reduction rate of 23.3 ± 15.2%. Conclusions: This surgical technique showed significant improvement in the ROM of radial and palmar abduction and the VAS score for pain, and the combined fixation of the first and second metacarpals with suture button device suppressed the subsidence of the first metacarpal.

  SAGE Publications, Sep. 2022, HAND, 19(3) (3), 419 - 425

  Scientific journal


• OASL rs10774580 SNP is associated with Herpes Zoster infection in rheumatoid arthritis.

  Marowa Hashimoto, Keiko Funahashi, Ken Tsumiyama, Yoshinori Takashima, Toshihisa Maeda, Koji Fukuda, Shinya Hayashi, Ryosuke Kuroda, Tsukasa Matsubara

  Sep. 2022, Rheumatology: Current Research, 12(5) (5), 1000312, English

  [Refereed]

  Scientific journal


• 炭酸ガス経皮吸収療法と低出力超音波パルス療法(LIPUS)の併用はラットの骨折治癒を促進する

  澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 山本 裕也, 高瀬 恭平, 吉川 遼, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1550 - S1550, Japanese


• Masquelet法 Induced membrane由来細胞に対するLIPUSによる骨分化誘導

  高瀬 恭平, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 山本 裕也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1639 - S1639, Japanese


• Non-hypertrophic nonunionには骨分化能を有する細胞が存在し、E-BMP-2により骨・軟骨分化能が促進される

  吉川 遼, 新倉 隆宏, 福井 友章, 大江 啓介, 隈部 洋平, 小田 崇弘, 澤内 健一, 高瀬 恭平, 山本 裕也, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1643 - S1643, Japanese


• 骨折遷延治癒、偽関節のメカニズムから臨床応用へ 炭酸ガス経皮吸収による骨癒合促進

  新倉 隆宏, 大江 啓介, 福井 友章, 澤内 健一, 高瀬 恭平, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1734 - S1734, Japanese


• 骨組織由来細胞に対する高濃度抗菌薬の影響

  山本 裕也, 新倉 隆宏, 福井 友章, 大江 啓介, 高瀬 恭平, 吉川 遼, 澤内 健一, 圓尾 明弘, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1878 - S1878, Japanese


• 内軟骨腫との鑑別を要した小児中足骨発生の類上皮血管内皮腫の1例

  山本 顕, 藤原 周一, 原 仁美, 深瀬 直政, 澤田 良子, 黒田 良祐, 河本 旭哉, 秋末 敏宏

  (一社)中部日本整形外科災害外科学会, Sep. 2022, 中部日本整形外科災害外科学会雑誌, 65(5) (5), 746 - 746, Japanese


• Ewing肉腫におけるslow-cycling cellsの同定

  八尋 俊輔, 藤原 周一, 河本 旭哉, 原 仁美, 深瀬 直政, 竹森 俊幸, 北山 和道, 宮本 智弘, 青井 貴之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1761 - S1761, Japanese


• 骨肉腫細胞におけるsprr1aの機能の探索

  宮本 智弘, 河本 旭哉, 深瀬 直政, 竹森 俊幸, 藤原 周一, 北山 和道, 八尋 俊輔, 青井 貴之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1761 - S1761, Japanese


• Ewing肉腫におけるslow-cycling cellsの同定

  八尋 俊輔, 藤原 周一, 河本 旭哉, 原 仁美, 深瀬 直政, 竹森 俊幸, 北山 和道, 宮本 智弘, 青井 貴之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1761 - S1761, Japanese


• 骨肉腫細胞におけるsprr1aの機能の探索

  宮本 智弘, 河本 旭哉, 深瀬 直政, 竹森 俊幸, 藤原 周一, 北山 和道, 八尋 俊輔, 青井 貴之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1761 - S1761, Japanese


• Paracrine effect of the stromal vascular fraction containing M2 macrophages on human chondrocytes through the Smad2/3 signaling pathway.

  Masahiro Fujita, Tomoyuki Matsumoto, Shinya Hayashi, Shingo Hashimoto, Naoki Nakano, Toshihisa Maeda, Yuichi Kuroda, Yoshinori Takashima, Kenichi Kikuchi, Kensuke Anjiki, Kemmei Ikuta, Yuma Onoi, Shotaro Tachibana, Takehiko Matsushita, Hideki Iwaguro, Satoshi Sobajima, Takafumi Hiranaka, Ryosuke Kuroda

  The adipose-derived stromal vascular fraction (SVF) is composed of a heterogeneous mix of adipose-derived stem cells (ADSCs), macrophages, pericytes, fibroblasts, blood, and other cells. Previous studies have found that the paracrine effects of SVF cells may be therapeutic, but their role in osteoarthritis treatment remains unclear. This study aimed to investigate the therapeutic effect of SVF cells on chondrocytes. Chondrocytes were seeded on culture plates alone (control) or cocultured with SVF or ADSCs on cell culture inserts. After 48 h of coculture, chondrocyte collagen II, tissue inhibitors of metalloproteinases-3 (TIMP-3), and matrix metalloproteinases-13 (MMP-13) messenger RNA (mRNA) expression levels were evaluated using reverse-transcription polymerase chain reaction, and the transforming growth factor-β (TGF-β) levels in the supernatant were measured using ELISA. Immunohistochemical staining and flow cytometry were used to evaluate the macrophages in the SVF. These macrophages were characterized according to phenotype using the F4/80, CD86, and CD163 markers. To determine whether the Smad2/3 signaling pathways were involved, the chondrocytes were pre-treated with a Smad2/3 phosphorylation inhibitor and stimulated with the SVF, and then Smad2/3 phosphorylation levels were analyzed using western blot. The mRNA expression levels of various paracrine factors and chondrocyte pellet size were also assessed. Collagen II and TIMP-3 expression were higher in the SVF group than in the ADSC group and controls, while MMP-13 expression was the highest in the ADSC group and the lowest in the controls. TGF-β levels in the SVF group were also elevated. Immunohistochemical staining and flow cytometry revealed that the macrophages in the SVF were of the anti-inflammatory phenotype. Western blot analysis showed that the SVF increased Smad2/3 phosphorylation, while Smad2/3 inhibitors decreased phosphorylation. Smad2/3 inhibitors also reduced the expression of various other paracrine factors and decreased chondrocyte pellet size. These findings suggested that the paracrine effect of heterogeneous cells, such as anti-inflammatory macrophages, in the SVF partly supports chondrocyte regeneration through TGF-β-induced Smad2/3 phosphorylation.

  Sep. 2022, Journal of cellular physiology, 237(9) (9), 3627 - 3639, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Second-Look Arthroscopic Findings and Clinical Outcomes after Adipose-Derived Regenerative Cell Injection in Knee Osteoarthritis.

  Yuma Onoi, Takafumi Hiranaka, Yuichi Hida, Takaaki Fujishiro, Koji Okamoto, Tomoyuki Matsumoto, Ryosuke Kuroda

  BACKGROUND: To evaluate the clinical outcomes and second-look arthroscopic findings after intra-articular adipose-derived regenerative cell (ADRC) injection as treatment for knee osteoarthritis (OA). METHODS: ADRCs were administered to 11 patients (19 knees; mean age, 61.7 years) with knee OA. Subcutaneous adipose tissue was harvested by liposuction from both thighs, and arthroscopic lavage was performed, followed by ADRC injection (mean dose, 1.40 × 107 cells) into the synovial fluid. Outcome measures included the Knee Injury and Osteoarthritis Outcome Score, Lysholm score, and visual analog scale score. Arthroscopic examinations were performed to assess the International Cartilage Repair Society cartilage injury grade preoperatively and overall repair postoperatively. Noninvasive assessments were performed at baseline and at 1-, 3-, and 6-month follow-ups; arthroscopic assessments were performed at baseline and at 6 months. RESULTS: All outcome measures significantly improved after treatment. This improvement was evident 1 month after treatment and was sustained until the 6-month follow-up. Data from second-look arthroscopy showed better repair in low-grade cartilage lesions than in lesions with a greater degree of damage. No patients demonstrated worsening of Kellgren-Lawrence grade, and none underwent total knee arthroplasty during this period. CONCLUSIONS: Clinical outcomes were improved in patients with knee OA after ADRC administration. Cartilage regeneration was more effective in smaller damaged lesions than in bigger lesions.

  Sep. 2022, Clinics in orthopedic surgery, 14(3) (3), 377 - 385, English, International magazine

  Scientific journal


• The Effect of Prosthesis Type on Intraoperative Soft-Tissue Balance and Clinical Outcomes in Modified Kinematically Aligned Cruciate-Retaining Total Knee Arthroplasty

  Tomoyuki Matsumoto, Naoki Nakano, Kazunari Ishida, Yoshinori Takashima, Toshihisa Maeda, Yuichi Kuroda, Shinya Hayashi, Tekehiko Matsushita, Takahiro Niikura, Hirotsugu Muratsu, Ryosuke Kuroda

  Abstract Introduction Kinematically aligned total knee arthroplasty (KA-TKA) has gained interest for achieving more favorable clinical outcomes than mechanically aligned TKA. One of the advantages of KA-TKA is reported to be an easy acquisition of intraoperative soft-tissue balance without excessive medial release for varus osteoarthritis. However, we hypothesized that the prosthesis type affects intraoperative soft-tissue balance even in the KA-TKA. The present study aimed to compare intraoperative soft-tissue balance and clinical outcomes of KA-TKAs using single-radius (SR) or multiradius (MR) prostheses. Materials and Methods Consecutive 70 cruciate-retaining modified KA-TKAs (31 SR and 39 MR) were performed in patients with varus-type osteoarthritis using a navigation system. Intraoperative soft-tissue balance including joint component gap and varus/valgus balance was measured with femoral component placement and patellofemoral joint reduction throughout the range of motion using offset-type tensor and compared between the two groups. Two years postoperatively, the range of motion and 2011 Knee Society Scores were compared between the two groups. Results and Conclusion Joint component gaps showed no significant differences between the two groups from 0 to 30 degrees of flexion. However, during 60 to 120 degrees of flexion, joint component gaps of SR group showed significantly larger values than those of MR group (p < 0.05). There were no significant differences in varus/valgus balance throughout the range of motion between the two groups. The postoperative clinical outcomes showed no significant differences between the two groups. Interpretation Despite no difference in clinical outcomes, joint component gap showed different patterns due to the prosthesis type in modified KA-TKAs.

  Georg Thieme Verlag KG, Jul. 2022, The Journal of Knee Surgery, 36(10) (10), 1013 - 1019

  Scientific journal


• Management of Infected Non-union Following Femoral Shaft Fracture in a Patient with Klippel-Trenaunay Syndrome: A Case Report.

  Tetsuro Kurashina, Tomoaki Fukui, Keisuke Oe, Kenichi Sawauchi, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: The etiology of Klippel-Trenaunay syndrome (KTS) has a significant impact on the management of patient requiring surgical interventions. We report the strategies employed to address an infected non-union in a patient with KTS. CASE REPORT: The patient was transported to an initial treating hospital with femoral shaft fracture after experiencing a fall. The patient was diagnosed with KTS due to vascular malformations identified after severe intraoperative hemorrhaging. An open reduction and internal fixation was performed to stabilize the bone. Nine months after surgery, the patient was transferred to our hospital due to lack of healing with infected non-union. We prioritized treating the infection and plate displacement, and subsequently performed intramedullary nailing. Infection and intraoperative hemorrhaging were successfully controlled and bone union was confirmed 6 months after surgery. CONCLUSION: The key factors to minimize procedural complications are sufficient preoperative evaluation and planning, surgical skill, and perioperative resource management.

  Jul. 2022, Journal of orthopaedic case reports, 12(7) (7), 38 - 41, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Clinical Outcome of Patients with Pelvic and Retroperitoneal Bone and Soft Tissue Sarcoma: A Retrospective Multicenter Study in Japan

  Toshiyuki Takemori, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Shuichi Fujiwara, Ikuo Fujita, Takuya Fujimoto, Masayuki Morishita, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Masanori Saito, Jun Sugaya, Katsuhiro Hayashi, Hiroyuki Kawashima, Tomoaki Torigoe, Tomoki Nakamura, Hiroya Kondo, Toru Wakamatsu, Munenori Watanuki, Munehisa Kito, Satoshi Tsukushi, Akihito Nagano, Hidetatsu Outani, Shunichi Toki, Shunji Nishimura, Hiroshi Kobayashi, Itsuo Watanabe, Yusuke Demizu, Ryohei Sasaki, Takumi Fukumoto, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue

  This study aimed to retrospectively analyze the clinical outcomes of patients with pelvic and retroperitoneal bone and soft tissue sarcoma (BSTS). Overall, 187 patients with BSTS in the pelvis and retroperitoneal region treated at 19 specialized sarcoma centers in Japan were included. The prognostic factors related to overall survival (OS), local control (LC), and progression-free survival (PFS) were evaluated. The 3-year OS and LC rates in the 187 patients were 71.7% and 79.1%, respectively. The 3-year PFS in 166 patients without any distant metastases at the time of primary tumor diagnosis was 48.6%. Osteosarcoma showed significantly worse OS and PFS than other sarcomas of the pelvis and retroperitoneum. In the univariate analyses, larger primary tumor size, soft tissue tumor, distant metastasis at the time of primary tumor diagnosis, P2 location, chemotherapy, and osteosarcoma were poor prognostic factors correlated with OS. Larger primary tumor size, higher age, soft tissue tumor, chemotherapy, and osteosarcoma were poor prognostic factors correlated with PFS in patients without any metastasis at the initial presentation. Larger primary tumor size was the only poor prognostic factor correlation with LC. This study has clarified the epidemiology and prognosis of patients with pelvic and retroperitoneal BSTS in Japan.

  MDPI AG, Jun. 2022, Cancers, 14(12) (12), 3023 - 3023

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Iguratimod Versus Salazosulfapyridine in Rheumatoid Arthritis Patients with an Inadequate Response to Methotrexate: Adjusted with Propensity Score Matching.

  Yuji Nozaki, Motohiro Oribe, Daisuke Tomita, Tetsu Itami, Shinya Hayashi, Toshihisa Maeda, Koji Fukuda, Ryosuke Kuroda, Keiko Funahashi, Tsukasa Matsubara, Koji Kinoshita, Itaru Matsumura

  OBJECTIVES: Methotrexate (MTX) is recommended as a first-line conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) for treating rheumatoid arthritis (RA). No studies have established which csDMARDs are useful as add-on drugs for RA patients with an inadequate response (IR) to MTX. This retrospective study sought to identify an add-on csDMARD treatment strategy for RA patients with MTX-IR. PATIENTS AND METHODS: We collected the cases of RA patients treated with salazosulfapyridine (SASP) or iguratimod (IGU) as the additional csDMARD for MTX-IR during a 24-month follow-up at four institutions in Japan. We performed propensity score matching to evaluate the retention rate, clinical efficacy, and safety profile (n=54, each group). RESULTS: The retention rates at 24 months of combination therapy in the patients with any-reason discontinuations were 38.5% (MTX+SASP group) and 67.8% (MTX+IGU group). At 3 and 6 months of follow-up, the MTX+IGU group's DAS28-CRP was significantly decreased versus the MTX+SASP group, and at 3 months the MTX+IGU group's good-responder percentage (22.9%) was significantly higher versus the MTX+SASP group's (10.7%). Conversely, compared to the MTX+SASP group, the MTX+IGU group showed a greater reduction in the eGFR from baseline after 3 months during follow-up. CONCLUSIONS: IGU is a useful add-on csDMARD for RA patients with MTX-IR; its high retention rate and good clinical response make it a useful combination therapy for controlling RA disease activity. However, the renal function of these patients should be monitored during follow-up.

  Oxford University Press (OUP), Jun. 2022, Modern rheumatology, 33(3) (3), 472 - 480, English, International magazine

  Scientific journal


• The influence of ruptured scar pattern of human anterior cruciate ligament remnant tissue on tendon‐bone healing in vivo

  Yoshinori Takashima, Tomoyuki Matsumoto, Naoki Nakano, Tomoyuki Kamenaga, Yuichi Kuroda, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda

  Abstract The purpose of this study was to determine whether the transplantation of human cells from a non‐reattached injured anterior cruciate ligament (ACL) remnant could enhance tendon‐bone healing. Human ACL remnant tissue was classified into two groups based on the morphologic pattern as per Crain's classification: (1) non‐reattachment group (Crain Ⅳ) and (2) reattachment group (Crain Ⅰ–Ⅲ). Seventy‐five 10‐week‐old immunodeficient rats underwent ACL reconstruction followed by intracapsular administration of one of the following: (1) ACL‐derived cells from the non‐reattached remnant (non‐reattachment group) (n = 5), (2) ACL‐derived cells from the reattached tissue (reattachment group) (n = 5), or (3) phosphate‐buffered saline (PBS) only (PBS group) (n = 5). Histological (Weeks 2, 4, and 8), immunohistochemical (Week 2), radiographic (Weeks 0, 2, 4, and 8), and biomechanical (Week 8) assessments were performed. Histological evaluation showed high and early healing, induction of endochondral ossification‐like integration, and mature bone ingrowth at Week 4 in the non‐reattachment group. Microcomputed tomography at Week 4 showed that the tibial bone tunnels in the non‐reattachment group were significantly reduced compared to those in the reattachment and PBS groups. Moreover, biomechanical testing showed that ultimate load‐to‐failure in the non‐reattachment group tended to be larger than that in the reattachment group, though not statistically significant. The enhanced healing potential in the non‐reattachment group was explained by the increase in intrinsic angiogenesis/osteogenesis. In the subacute phase, the ACL‐derived cells with the non‐reattached morphologic pattern showed greater and earlier tendon bone healing compared with the cells obtained from the reattached morphologic pattern.

  Wiley, Jun. 2022, Journal of Orthopaedic Research, 41(3) (3), 500 - 510

  Scientific journal


• 転移性骨腫瘍(切迫骨折の治療) 寛骨臼転移性骨腫瘍に対して病巣掻爬後に内固定および骨セメント充填を行った3例

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2022, 骨折, 44(Suppl.) (Suppl.), S68 - S68, Japanese


• 高齢大腿骨頸部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化について 多施設共同研究

  大江 啓介, 新倉 隆宏, 福井 友章, 高原 俊介, 岩倉 崇, 角田 雅也, 櫻井 敦志, 正田 悦朗, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2022, 骨折, 44(Suppl.) (Suppl.), S217 - S217, Japanese


• 患者立脚型機能評価による上肢偽関節の治療成績の検討

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2022, 骨折, 44(Suppl.) (Suppl.), S268 - S268, Japanese


• 類上皮肉腫に対するホウ素中性子捕捉療法(BNCT)を用いた新たな治療方法の開発

  藤本 卓也, 安藤 徹, 佐久間 淑子, 藤田 郁夫, 森下 雅之, 藤田 昌秀, 河本 旭哉, 黒田 良祐, 秋末 敏宏, 廣瀬 隆則, 鈴木 実

  (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1300 - S1300, Japanese


• 骨肉腫肺転移症例の検討

  河本 旭哉, 森下 雅之, 原 仁美, 深瀬 直政, 竹森 俊幸, 藤原 周一, 北山 和道, 八尋 俊輔, 宮本 智弘, 藤田 郁夫, 藤本 卓也, 藤田 昌秀, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1346 - S1346, Japanese


• 骨盤発生悪性骨・軟部腫瘍の治療成績と予後因子の検討

  竹森 俊幸, 河本 旭哉, 原 仁美, 深瀬 直政, 藤原 周一, 齊藤 正徳, 岩田 慎太郎, 林 克洋, 川島 寛之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1348 - S1348, Japanese


• 手足に生じた軟部肉腫の治療成績と予後因子に関する検討

  小西 赳広, 竹森 俊幸, 河本 旭哉, 原 仁美, 深瀬 直政, 藤原 周一, 北山 和道, 八尋 俊輔, 宮本 智弘, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1352 - S1352, Japanese


• 悪性末梢神経鞘腫瘍の治療成績

  藤原 周一, 藤田 昌秀, 河本 旭哉, 藤田 郁夫, 藤本 卓也, 原 仁美, 深瀬 直政, 森下 雅之, 竹森 俊幸, 秋末 敏宏, 黒田 良祐

  (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1356 - S1356, Japanese


• 腹腔外デスモイド型線維腫症に対するWait & Seeの治療成績

  藤田 郁夫, 藤原 周一, 藤本 卓也, 森下 雅之, 河本 旭哉, 原 仁美, 深瀬 直政, 竹森 俊幸, 北山 和道, 八尋 俊輔, 宮本 智弘, 秋末 敏宏, 黒田 良祐

  (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1371 - S1371, Japanese


• Ewing肉腫におけるslow-cycling cellの同定

  八尋 俊輔, 河本 旭哉, 原 仁美, 深瀬 直政, 竹森 俊幸, 藤原 周一, 北山 和道, 宮本 智弘, 青井 貴之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1428 - S1428, Japanese


• 明細胞肉腫薬物治療におけるLAT1阻害剤による増感効果の検討

  森下 雅之, 藤本 卓也, 河本 旭哉, 須藤 保, 藤田 郁夫, 藤田 昌秀, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1432 - S1432, Japanese


• Robotic arm-assisted posterior-stabilised total knee arthroplasty reduces the amount of tibial bone resection thickness without increasing the rate of postoperative flexion contracture in varus knees in the short term: Comparison with image-free navigated total knee arthroplasty.

  Kazunari Ishida, Nao Shibanuma, Shinya Hayashi, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: This study aimed to compare the bone resection thickness, rate of minimal thickness insert usage, and postoperative range of motion (ROM) between robotic and navigated total knee arthroplasty (TKA). METHODS: Fifty consecutive posterior-stabilised (PS) robotic TKA and 50 case-controlled PS navigated TKA were enroled. Bone resection thickness, rate of minimal thickness insert usage, and postoperative flexion contracture over 5° were statistically compared. RESULTS: The tibial bone resection thickness was significantly thinner in robotic TKA. The insert thickness was significantly lower, and the rate of minimal thickness insert usage was significantly higher in robotic TKA. The ROM at 3 months postoperatively and the rate of postoperative flexion contracture were comparable between the two groups. CONCLUSION: Robotic TKA can reduce the tibial bone resection thickness and increase the rate of minimal thickness insert usage without increasing postoperative flexion contracture as compared with navigated TKA.

  Jun. 2022, The international journal of medical robotics + computer assisted surgery : MRCAS, 18(3) (3), e2370, English, International magazine

  Scientific journal


• Assessment of the upper limb muscles in patients with Fukuyama muscular dystrophy: Noninvasive assessment using visual ultrasound muscle analysis and shear wave elastography

  Harada R, Taniguchi-Ikeda M, Nagasaka M, Tatsiuya Nishii, Atsuyuki Inui, Tetsushi Yamamoto, Ichiro Morioka, Ryosuke Kuroda, Kazumoto Iijima, Kandai Nozu, Yoshitada Sakai, Tatsushi Toda

  May 2022, Neuromuscular Disorders

  Link to Kobe Univ. Repository (Kernel)


• A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy.

  Yu Hirata, Kazuhiro Nomura, Daisuke Kato, Yoshihisa Tachibana, Takahiro Niikura, Kana Uchiyama, Tetsuya Hosooka, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Yuji Hara, Takahiro Adachi, Koji Shibasaki, Hiroaki Wake, Wataru Ogawa

  Although immobility is a common cause of muscle atrophy, the mechanism underlying this causality is unclear. We here show that Krüppel-like factor 15 (KLF15) and IL-6 are upregulated in skeletal muscle of limb-immobilized mice and that mice with KLF15 deficiency in skeletal muscle or with systemic IL-6 deficiency are protected from immobility-induced muscle atrophy. A newly developed Ca2+ bioimaging revealed that the cytosolic Ca2+ concentration ([Ca2+]i) of skeletal muscle is reduced to below the basal level by immobilization, which is associated with the downregulation of Piezo1. Acute disruption of Piezo1 in skeletal muscle induced Klf15 and Il6 expression as well as muscle atrophy, which was prevented by antibodies against IL-6. A role for the Piezo1/KLF15/IL-6 axis in immobility-induced muscle atrophy was validated in human samples. Our results thus uncover a paradigm for Ca2+ signaling in that a decrease in [Ca2+]i from the basal level triggers a defined biological event.

  May 2022, The Journal of clinical investigation, 132(10) (10), 1 - 13, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Comparative Study of Circumferential Decompression and Posterior Decompression in Palliative Surgery for Metastatic Thoracic Spinal Tumors.

  Bungo Otsuki, Kunihiko Miyazaki, Kenichiro Kakutani, Shunsuke Fujibayashi, Takayoshi Shimizu, Koichi Murata, Yoshimitsu Takahashi, Takeo Nakayama, Ryosuke Kuroda, Shuichi Matsuda

  STUDY DESIGN: This was a case-control study. OBJECTIVE: The present study aimed to evaluate the significance of circumferential tumor resection around the spinal cord in palliative decompression surgery for patients with metastatic spinal cord compression (MSCC) in the thoracic spine. SUMMARY OF BACKGROUND DATA: Although the benefits of palliative surgery for MSCC are well known, the significance of circumferential tumor resection with cord compression has not yet been clarified. MATERIALS AND METHODS: We retrospectively compared the outcomes of 45 and 34 patients with incomplete paralysis of modified Frankel grade B-D caused by MSCC with anterior cord compression (epidural spinal cord compression grade ≥2) treated at 2 different university hospitals (H1 and H2, respectively). All patients in H1 hospital underwent posterior decompression only, while all patients in H2 hospital underwent full circumferential decompression. We analyzed factors that affect the postoperative ambulatory status. evaluated by the modified Frankel classification. RESULTS: No significant differences were observed in the epidural spinal cord compression grade, spinal instability neoplastic score, new Katagiri score, revised Tokuhashi score, or postoperative survival between patients in H1 and H2 hospitals. A multivariable logistic regression analysis identified preoperative radiotherapy [odds ratio (OR): 0.23, 95% confidential interval (CI): 0.056-0.94] as a negative risk factor and postoperative chemotherapy (OR: 5.9, 95% CI: 1.3-27.0) as a positive risk factor for an improved ambulatory status. Five and 6 patients in H1 and H2 hospitals, respectively, showed deterioration in the ambulatory status. An older age (OR: 1.1, 95% CI: 1.0-1.2) and preoperative radiotherapy (OR: 10.3, 95% CI: 1.9-55.4) were extracted as significant independent risk factors for deterioration in the ambulatory status. Circumferential decompression did not improve the clinical results of patients regardless of the degree of paralysis. CONCLUSIONS: Preoperative radiotherapy interfered with the recovery of paralysis, and postoperative chemotherapy improved the ambulatory status. Clinical outcomes did not significantly differ between total circumferential decompression and posterior decompression, although further validation in a small number of cases is needed, such as patients with Frankel grade D.

  May 2022, Clinical spine surgery, English, International magazine

  Scientific journal


• Analysis of popliteal artery location for high tibial and distal tuberosity osteotomy using contrast-enhanced computed tomography.

  Akiyoshi Mori, Takehiko Matsushita, Nobuaki Miyaji, Kanto Nagai, Daisuke Araki, Noriyuki Kanzaki, Tomoyuki Matsumoto, Takahiro Niikura, Yuichi Hoshino, Ryosuke Kuroda

  BACKGROUND: Our objective was to evaluate the location of popliteal artery (PA) in osteotomy planes during high tibial osteotomy (HTO) and to determine a safer angle for screw drilling to the tibial tuberosity during distal tuberosity osteotomy (DTO). METHODS: Twenty knees in 20 patients who underwent contrast-enhanced computed tomography for cardiovascular diseases were examined. Osteotomy planes for open-wedge HTO (OWHTO) and hybrid closed-wedge HTO (hybrid CWHTO) were created using three-dimensional bone models. The distance from the posterior cortex of the tibia to the PA (dPC-PA) in the osteotomy planes was measured in the virtual osteotomy planes. The dangerous point (Point D1) was defined as the point 17.5 mm away from PA, setting the working length of the bone saw as 35 mm. The distance between the most medial point of the tibial cortex (Point M) and Point D1 in OWHTO and the most lateral point (Point L) and Point D1 in hybrid CWHTO were examined (dM-D1 and dL-D1, respectively). The location of Point D1 to the osteotomy line (%D1) was expressed as percentage, setting the start and end of the osteotomy line as 0% and 100%, respectively. To determine the safe angle for screw drilling in DTO, the angle between the line tangential to the medial cortex of the tibia and that passing through the center of the tibial tuberosity and PA were measured. RESULTS: In OWHTO and hybrid CWHTO, the mean dPC-PA was 10.6 mm (6.9-16.5 mm) and 10.2 mm (7.3-15.4 mm), respectively. The mean dM-D1 in OWHTO was 25.9 mm (24.6-27.2 mm) and dL-D1 in hybrid CWHTO was 5.1 mm (2.9-7.4 mm). The mean %D1 was 47.6 ± 3.7% in OWHTO and 9.3 ± 4.1% in hybrid CWHTO, respectively. The minimal angle between the two lines in DTO was 35.2°. CONCLUSION: PAs could run within 10 mm from the posterior cortex in the osteotomy planes of HTO. Therefore, proper posterior protection is necessary when cutting posterior cortex. An angle of less than 35° against the medial cortex line would be safe for screw fixation to avoid vascular injury in DTO.

  May 2022, Knee surgery & related research, 34(1) (1), 25 - 25, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 慢性再発性多発性骨髄炎の1例

  島 稔樹, 竹森 俊幸, 河本 旭哉, 原 仁美, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, May 2022, 中部日本整形外科災害外科学会雑誌, 65(3) (3), 403 - 404, Japanese


• Association Between Meeting Return-to-Sport Criteria and Psychological Readiness to Return to Sport After Anterior Cruciate Ligament Reconstruction.

  Yuya Ueda, Takehiko Matsushita, Yohei Shibata, Kohei Takiguchi, Kumiko Ono, Akihiro Kida, Rei Ono, Kanto Nagai, Yuichi Hoshino, Tomoyuki Matsumoto, Yoshitada Sakai, Ryosuke Kuroda

  Background: The relationship between meeting return-to-sport criteria and psychological readiness after anterior cruciate ligament (ACL) reconstruction is unknown. Purposes: To examine (1) whether patients who met 1 of the criteria for return to sport had higher psychological readiness than those who did not meet any of the criteria and (2) if those who met more criteria had higher psychological readiness. Study Design: Cross-sectional study; Level of evidence, 3. Methods: This study included 144 patients who underwent unilateral ACL reconstruction. All patients had regularly participated in some sport activities before an ACL rupture. At 12 months postoperatively, each patient completed 3 knee function tests (isokinetic quadriceps strength, isokinetic hamstring strength, and single-leg hop distance) and 2 self-reported measures (International Knee Documentation Committee [IKDC] 2000 subjective form and ACL-Return to Sport after Injury [ACL-RSI] scale); the ACL-RSI scale was used to measure psychological readiness to return to sport. The 4 criteria for return to sport were a limb symmetry index (LSI) ≥90% for each of the 3 function tests in addition to an IKDC score ≥90. Multivariate regression analysis was used to determine the association between meeting the individual criteria and the ACL-RSI score. In addition, the patients were divided into 5 groups according to the number of criteria met, and the Kruskal-Wallis and Steel-Dwass tests were used to compare the ACL-RSI scores among the groups. Results: Overall, 23 patients (16.0%) met none of the criteria for return to sport, 27 (18.7%) met 1 of the criteria, 34 (23.6%) met 2 criteria, 35 (24.3%) met 3 criteria, and 25 (17.4%) met all 4 criteria. Meeting the criteria for the hamstring strength LSI (P = .002), single-leg hop distance LSI (P = .004), and IKDC subjective score (P < .001) was each associated with higher ACL-RSI scores. Significant differences in ACL-RSI scores were found between patients who met none versus 2, 3, and 4 of the return-to-sport criteria (P < .001 for all) and between patients who met 1 versus 4 criteria (P < .001). Conclusion: Meeting return-to-sport criteria was positively associated with psychological readiness, and the patients who met multiple criteria had higher psychological readiness.

  May 2022, Orthopaedic journal of sports medicine, 10(5) (5), 23259671221093985 - 23259671221093985, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Biochemical Markers of Aging (Advanced Glycation End Products) and Degeneration Are Increased in Type 3 Rotator Cuff Tendon Stumps With Increased Signal Intensity Changes on MRI.

  Issei Shinohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Tatsuo Kato, Takahiro Furukawa, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Advanced glycation end products (AGEs) are end products of protein glycation that bind to the receptor for AGEs (RAGE) and activate nicotinamide adenine dinucleotide phosphate oxidase (NOX), resulting in increased oxidative stress and rotator cuff fragility. Stump classification using the signal intensity ratio of the tendon rupture site to the deltoid muscle in the coronal view of T2-weighted fat-suppressed magnetic resonance imaging (MRI) scans is an indicator of clinical outcomes after rotator cuff repair surgery. Comparing the signal intensities of the deltoid (D) and rotator cuff tears (C), Ishitani et al. classified C/D <0.8 as type 1, 0.8 to 1.3 as type 2, and >1.3 as type 3. HYPOTHESIS/PURPOSE: It was hypothesized that the oxidative stress and collagen degeneration that occur in the rotator cuff due to accumulation of AGEs can be assessed on MRI scans (stump classification). Therefore, this study aimed to compare AGE-related factors in the rotator cuff tear site tissues based on stump classification. STUDY DESIGN: Descriptive laboratory study. METHODS: The authors included 30 patients (11 with type 1, 9 with type 2, and 10 with type 3; mean age, 62.3 years) who underwent surgery for complete rotator cuff tears at our hospital. Tendon tissue was harvested from the torn rotator cuff site during surgery for tissue and cell evaluation. RESULTS: There was no significant difference in the mean age according to stump classification. The number of patients with diabetes was significantly larger in type 3 than in the other types (P < .05). Tissue evaluation showed significantly higher expression of AGE and RAGE staining in type 3 than in the other types (~6.7-fold; P < .01). Cell evaluation showed that the expression rates of reactive oxygen species and apoptosis were significantly higher in type 3 than in the other types (~4.3-fold; P < .01). Gene expression by real-time polymerase chain reaction showed significantly higher RAGE (~5.1-fold), NOX (~5.3-fold), and IL (~3.0-fold) in type 3 than in the other types (P < .05). CONCLUSION: Stump classification type 3 exhibited the highest accumulation of AGEs and the highest oxidative stress and apoptosis, suggesting a high degree of degeneration and inflammation. Imaging based on stump classification reflects the degeneration and fragility of the torn rotator cuff site. CLINICAL RELEVANCE: This study provides evidence of a relationship between stump classification, which reflects rotator cuff fragility on MRI, and pathologies related to advanced glycation end products.

  Apr. 2022, The American journal of sports medicine, 3635465221090649 - 3635465221090649, English, International magazine

  Scientific journal


• Successful Conservative Treatment of an Acute Arterial Occlusion After Total Knee Arthroplasty: Report of 2 Cases and Review of the Literature.

  Kemmei Ikuta, Tomoyuki Matsumoto, Koji Takayama, Naoki Nakano, Yoshinori Takashima, Hiroki Ohnishi, Shinya Hayashi, Yuichi Kuroda, Ryosuke Kuroda

  BACKGROUND Acute arterial occlusion after total knee arthroplasty (TKA) is a rare but occasionally limb-threatening complication. Successful outcomes of surgical treatment for acute arterial occlusion after TKA have been frequently reported in the literature; however, few reports have described conservative treatment. This case report describes the successful conservative treatment of popliteal artery occlusion after TKA. CASE REPORT We report 2 cases of popliteal artery occlusion after TKA that were managed with conservative treatment. In Case 1, a 68-year-old woman presented with a weak dorsalis pedis pulse in the foot and weakness to dorsiflexion of the toe on the operative side immediately after TKA. The operative lower extremity arterial ultrasonography and computed tomography angiography demonstrated the popliteal artery occlusion. In Case 2, a 79-year-old woman presented a cold right foot and lack of popliteal and dorsalis pedis pulse in the operated extremity immediately after TKA, and Doppler ultrasound did not reveal a flow for the dorsalis pedis artery. In both patients, urgent angiographies showed popliteal artery occlusion, and blood flow was observable in the anterior tibial, peroneal, and foot arteries collateral perfusion. Thus, conservative treatments were chosen, and anticoagulant and vasodilator therapies were undergone in both patients. At 6 months after surgery, they were able to walk without intermittent claudication. CONCLUSIONS Conservative treatment can be a good option for popliteal artery occlusion after TKA in cases of rich collateral circulation.

  Apr. 2022, The American journal of case reports, 23, e936295, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Evaluation of morphological characteristics for incomplete discoid medial meniscus with an oversized posterior segment.

  Shotaro Araki, Masanori Tsubosaka, Hirotsugu Muratsu, Takao Inokuchi, Hiroaki Maruo, Hidetoshi Miya, Ryosuke Kuroda, Takehiko Matsushita

  BACKGROUND: A discoid medial meniscus is rare in comparison with a discoid lateral meniscus. We encountered a new type of incomplete discoid with an oversized posterior segment. Therefore, this study aimed to report cases of medial meniscus with an oversized posterior segment and analyze the morphological characteristics by comparing them to cases with a discoid medial meniscus and normal medial meniscus. METHODS: Four patients with an oversized posterior segment medial meniscus (oversize group, mean age: 25.3 ± 12.0 years) and seven patients with a discoid medial meniscus (discoid group, mean age: 34.4 ± 19.6) were identified using magnetic resonance imaging (MRI) and diagnosed by arthroscopic findings in our hospital. Fifty patients without medial meniscal injury were retrospectively selected as the normal group (normal group, mean age: 24.0 ± 11.3 years). The clinical symptoms were examined. The anteroposterior (AP) length of both the anterior and posterior segments, AP length ratio of the posterior segment to the AP length of the medial tibial plateau, and mediolateral (ML) width of the mid-body of the medial meniscus were also evaluated using MRI and compared among the three groups. RESULTS: All patients in the oversize group complained of medial knee pain during deep knee flexion. In sagittal MRI, posteriorly deviated indentations were also observed at the medial tibial plateau in all cases in the oversize group. There was a significant difference in the AP length of the posterior segment between the normal and oversize groups (14.3 ± 2.8 vs. 23.6 ± 2.8 mm, P < 0.001), whereas there was no significant difference in the AP length of the anterior segment (9.1 ± 2.1 vs. 9.5 ± 1.9 mm, P = 0.869). The ML width of the mid-body in the normal, oversize, and discoid groups was 9.3 ± 1.8, 19.9 ± 2.6, and 25.8 ± 1.9 mm, respectively (normal vs. oversize group: P < 0.001, oversize vs discoid group: P = 0.01, normal vs. discoid group: P < 0.001). CONCLUSIONS: Oversized posterior and normal anterior segments characterize this new type of incomplete discoid medial meniscus as a morphological abnormality.

  Apr. 2022, Journal of orthopaedic surgery and research, 17(1) (1), 245 - 245, English, International magazine

  Scientific journal


• Ultrasound With Artificial Intelligence Models Predicted Palmer 1B Triangular Fibrocartilage Complex Injuries.

  Issei Shinohara, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Shintaro Mukohara, Tomoya Yoshikawa, Ryosuke Kuroda

  PURPOSE: To calculate the diagnostic accuracy from the confusion matrix using deep learning (DL) on ultrasound (US) images of Palmer 1B triangular fibrocartilage complex (TFCC) injury. METHODS: Twenty-nine wrists of 15 healthy volunteers (11 men; mean age, 34.9 years ± 9.7) (control group) and 20 wrists of 17 patients (11 men; mean age 41.0 years ± 12.2) with TFCC injury (Palmer type IB) (injury group) were included in the study. The diagnosis of Palmer 1B TFCC injury was made using magnetic resonance imaging, computed tomography arthrography, and intraoperative arthroscopic findings. In total, 2,000 images were provided to each group, 80% of which were randomly selected by AI and used as training data; the remaining data were used as test data. Transfer learning was conducted using a pretrained 3 separate models (GoogLeNet, ResNet50, ResNet101). Model evaluation was performed using a confusion matrix. The area under a receiver operating characteristic curve was also calculated. The occlusion sensitivity was used to visualize the important features. RESULTS: For the prediction of TFCC injury by the DL model, the best score of accuracy was 0.85 in GoogLeNet, a recall was 1.0 in ResNet50 and ResNet101, and a specificity was 0.78 in GoogLeNet. In predicting the TFCC injury for the test data, the best score of the AUC was 0.97 on ResNet101. Visualization of important features showed that AI predicted the presence of injury by focusing on the morphology of the articular disc. CONCLUSIONS: US images using the DL model predicted Palmer 1B TFCC injury with high accuracy, with the best scores of 0.85 for accuracy on GoogLeNet, 1.00 for sensitivity on ResNet50 and ResNet101, and 0.78 for specificity on GoogLeNet. The use of DL for US imaging of Palmer 1B TFCC injury predicted the injury as well as magnetic resonance imaging and computed tomography arthrography LEVEL OF EVIDENCE: IV; retrospective case series study.

  Apr. 2022, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, English, International magazine

  Scientific journal


• The coronal lateral collateral ligament sign in the anterior cruciate ligament-injured knees was observed regardless of the knee laxity based on the quantitative measurements.

  Chih-Kai Hong, Yuichi Hoshino, Shu Watanabe, Kanto Nagai, Takehiko Matsushita, Wei-Ren Su, Ryosuke Kuroda

  PURPOSE: The coronal lateral collateral ligament (LCL) sign has been reported to be associated with deviated position of the tibia on MRI due to anterior cruciate ligament (ACL) injuries. However, the relationships between LCL sign and clinical knee laxity evaluations are still unclear. The purpose of the study was to investigate the relationship between the coronal LCL sign and knee laxity measurements. METHODS: A retrospective review of unilateral ACL injured patients who underwent ACL reconstruction was performed. The coronal LCL sign was determined using magnetic resonance imaging (MRI). Clinical grading of the pivot-shift test, KT-1000 measurements, and quantitative measurements of the Lachman test and the pivot-shift test using an electromagnetic system, were compared between patients with positive and negative coronal LCL sign. A subgroup analysis of different age groups was then performed, dividing patients to adolescent (age ≤ 18 years) and adult (age > 18 years) groups. RESULTS: A total of 85 patients were enrolled, of which 45 patients had coronal LCL signs. The coronal LCL sign was not associated with the pivot-shift test clinical grading (n.s), KT-1000 measurement (n.s), the tibial translation during the Lachman test (n.s), or with tibia acceleration (n.s) and translation (n.s) during the pivot-shift test. The subgroup analysis also showed that the aforementioned parameters were not associated with the coronal LCL sign in either adolescent or adult subgroups. CONCLUSION: The occurrence of coronal LCL sign in MRI did not imply greater clinical knee laxity evaluations in patients with ACL tears. The knee laxity should routinely be evaluated regardless the coronal LCL sign. LEVEL OF EVIDENCE: Level III.

  Apr. 2022, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Influence of Diabetes-Induced Glycation and Oxidative Stress on the Human Rotator Cuff.

  Tomoya Yoshikawa, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Kohei Yamaura, Shintaro Mukohara, Issei Shinohara, Ryosuke Kuroda

  Most shoulder rotator cuff tears (RCTs) are caused by non-traumatic age-related rotator cuff degeneration, of which hyperglycemia is a risk factor due to its glycation reaction and oxidative stress. We aimed to identify the influence of diabetes-induced glycation and oxidative stress in patients with non-traumatic shoulder RCTs. Twenty patients, aged over 50 years, with non-traumatic shoulder RCTs participated in this study. Patients with a history of diabetes mellitus or preoperative HbA1c ≥ 6.5% were assigned to the diabetic group (n = 10), and the rest to the non-diabetic group (n = 10). Cell proliferation; expression of genes related to oxidative stress, glycation reaction, inflammation, and collagen; intracellular reactive oxygen species (ROS) levels; and apoptosis rates were analyzed. The diabetic group had significantly lower cell proliferation than the non-diabetic group. In the diabetic group, the mRNA expression levels of NOX1, NOX4, IL6, RAGE, type III collagen, MMP2, TIMP1, and TIMP2 were significantly higher; type I collagen expression was significantly lower; and the rate of ROS-positive cells and apoptotic cells, as well as the expression of advanced glycation end-products (AGEs) and the receptor for AGEs (RAGE), was significantly higher. In conclusion, hyperglycemia caused by diabetes mellitus increased AGE and RAGE expression, and led to increased NOX expression, ROS production, and apoptosis in the human rotator cuff. This provides scope to find a preventive treatment for non-traumatic RCTs by inhibiting glycation and oxidative stress.

  Apr. 2022, Antioxidants (Basel, Switzerland), 11(4) (4), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 創外固定治療とMasquelet法のコラボレーション

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  日本四肢再建・創外固定学会, Apr. 2022, 日本四肢再建・創外固定学会雑誌, 33, 161 - 161, Japanese


• KLF15を介した筋萎縮の分子機構の解明

  平田 悠, 野村 和弘, 加藤 大輔, 橘 吉寿, 新倉 隆宏, 内山 奏, 細岡 哲也, 福井 友章, 大江 啓介, 黒田 良祐, 原 雄二, 安達 貴弘, 柴崎 貢志, 和氣 弘明, 小川 渉

  (一社)日本糖尿病学会, Apr. 2022, 糖尿病, 65(Suppl.1) (Suppl.1), S - 122, Japanese


• 手足に生じた軟部肉腫の予後に関する検討

  小西 赳広, 竹森 俊幸, 河本 旭哉, 深瀬 直政, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2022, 中部日本整形外科災害外科学会雑誌, 65(春季学会) (春季学会), 123 - 123, Japanese


• 脂肪組織由来間質血管細胞群の軟骨細胞への作用機序の検討

  藤田 雅広, 松本 知之, 林 申也, 傍島 聰, 平中 崇文, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2022, 中部日本整形外科災害外科学会雑誌, 65(春季学会) (春季学会), 143 - 143, Japanese


• KLF15を介した筋萎縮の分子機構の解明

  平田 悠, 野村 和弘, 加藤 大輔, 橘 吉寿, 新倉 隆宏, 内山 奏, 細岡 哲也, 福井 友章, 大江 啓介, 黒田 良祐, 原 雄二, 安達 貴弘, 柴崎 貢志, 和氣 弘明, 小川 渉

  (一社)日本糖尿病学会, Apr. 2022, 糖尿病, 65(Suppl.1) (Suppl.1), S - 122, Japanese


• 骨形成不全症患者に生じた非定型大腿骨骨折の1例

  上出 將志, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2022, 中部日本整形外科災害外科学会雑誌, 65(春季学会) (春季学会), 146 - 146, Japanese


• 大腿骨近位髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について 多施設共同前向き観察研究

  大江 啓介, 新倉 隆宏, 福井 友章, 林 申也, 黒田 良祐, 酒井 良忠

  (一社)中部日本整形外科災害外科学会, Apr. 2022, 中部日本整形外科災害外科学会雑誌, 65(春季学会) (春季学会), 158 - 158, Japanese


• Comparison of Clinical Outcomes Between Ceramic-Based Total Ankle Arthroplasty with Ceramic Total Talar Prosthesis and Ceramic-Based Total Ankle Arthroplasty.

  Tetsuya Yamamoto, Kanto Nagai, Noriyuki Kanzaki, Kiminari Kataoka, Koji Nukuto, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Total ankle arthroplasty (TAA) has become one of the standard surgical treatments for patients with end-stage ankle osteoarthritis (OA). In recent years, TAA with total talar prosthesis (combined TAA) has been used for ankle OA patients with talar osteonecrosis, with severe talar collapse, or with subtalar joint OA. The purpose of this study was to investigate the functional and clinical outcomes of combined TAA, compared with conventional TAA. METHODS: Forty-six ankles (44 patients, 32 women/12 men) that underwent conventional TAA with mean follow-up of 42 months, and 26 ankles (25 patients, 18 women/7 men) that underwent combined TAA with mean follow-up of 46 months were included. Clinical outcomes, which included ankle range of motion (ROM), the Japanese Society for Surgery of the Foot (JSSF) ankle-hindfoot scale, the Self-Administered Foot Evaluation Questionnaire (SAFE-Q), and complications were compared between the groups. RESULTS: The preoperative ROM was significantly worse in combined TAA for both dorsiflexion and plantarflexion; however, in the final ROM, there was no significant difference between the groups. There was no significant difference in JSSF scale and SAFE-Q between the groups. Revision rate was 10.9% in conventional TAA and 0% in combined TAA. CONCLUSION: In this small series, at an average of 3.5 years, we found no significant difference in clinical results between conventional TAA and combined TAA; however, the revision rate was higher in conventional TAA. LEVEL OF EVIDENCE: Level III, retrospective cohort study.

  Apr. 2022, Foot & ankle international, 43(4) (4), 529 - 539, English, International magazine

  Scientific journal


• Risk factors of residual pivot-shift after anatomic double-bundle anterior cruciate ligament reconstruction

  Kohei Kamada, Takehiko Matsushita, Kanto Nagai, Yuichi Hoshino, Daisuke Araki, Noriyuki Kanzaki, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda

  INTRODUCTION: Although anterior cruciate ligament reconstruction (ACLR) is considered a successful procedure, residual pivot-shift after surgery remains to be solved. The purpose of this study was to comprehensively evaluate the risk factors of residual pivot-shift after anatomic double-bundle (DB) ACLR. MATERIALS AND METHODS: A total of 164 patients who underwent primary anatomic DB-ACLR between January 2014 and December 2019 and screw removal after the index ACLR in our hospital were included in this retrospective case-control study. The manual pivot-shift test was performed under general anesthesia during screw removal surgery, and patients with grade 1 or higher pivot-shift were classified as the positive pivot-shift group, and those with grade 0 were defined as the negative pivot-shift group. Univariate and logistic regression analyses were performed to identify the factors associated with postoperative residual pivot-shift. Assessment included sex, age, time to surgery, preoperative Tegner activity scale, preoperative pivot-shift grade, preoperative anterior tibial translation by the KT-2000 arthrometer measurement, meniscus injury and its surgical procedure, knee hyperextension, cartilage damage, Segond fracture, medial and lateral posterior tibial slope, lateral-medial slope asymmetry, participation in pivoting sport/activity at the time of injury, and return to sports at postoperative one year line. RESULTS: Postoperative positive pivot-shift was observed in 14 (8.5%) of 164 patients. The KT-2000 measurement at 1-year postoperatively was significantly higher in the residual pivot-shift-positive group than in the negative group (P < 0.05). Logistic regression analysis revealed that age of patients < 20 years [P < 0.05, odds ratio (OR): 6.1)], preoperative pivot-shift grade (P < 0.05, OR: 4.4), and hyperextended knee (P < 0.05, OR: 11.8) were risk factors of postoperative pivot-shift. There were no statistically significant differences between other variables. CONCLUSIONS: Patients < 20 years of age, with high-grade preoperative pivot-shift, or hyperextended knees had a higher risk of residual postoperative pivot-shift.

  Springer Science and Business Media LLC, Apr. 2022, Archives of Orthopaedic and Trauma Surgery, 143(2) (2), 977 - 985, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A phase I/IIa clinical trial of third-generation autologous chondrocyte implantation (IK-01) for focal cartilage injury of the knee.

  Takehiko Matsushita, Tomoyuki Matsumoto, Daisuke Araki, Kanto Nagai, Yuichi Hoshino, Takahiro Niikura, Atsuhiko Kawamoto, Masahiro J Go, Shin Kawamata, Masanori Fukushima, Ryosuke Kuroda

  Background/objective: The purpose of this study was to report the outcomes of a clinical trial conducted in Japan to assess the safety and effectiveness of third-generation autologous chondrocyte implantation (ACI) using IK-01 (CaReS™), which does not require flap coverage, in the treatment of patients with focal cartilage injury of the knee. Methods: This was an open label, exploratory clinical trial. Patients were enrolled between June 2012 and September 2016. The primary endpoint of the study was the International Knee Documentation Committee (IKDC) score at 52 weeks after implantation. The IKDC, Lysholm, and visual analog scale (VAS) scores were evaluated at the time of screening and at 4, 12, 24, 36, and 52 weeks after implantation. Improvements from the baseline scores were evaluated using the equation "(postoperative score) - (preoperative score)." Magnetic resonance imaging (MRI) was performed at 2, 12, 24, and 52 weeks after implantation, and MRI measurements were evaluated using T1 rho and T2 mapping. Results: Nine patients were enrolled in this study and were examined for safety. Product quality did not satisfy the specification in one patient, and bacterial joint infection occurred in one patient. As a result, seven patients were included in the outcome analyses. The mean IKDC score significantly improved from 36.4 preoperatively to 74.1% at 52 weeks after implantation (p < 0.0001). The mean Lysholm and VAS scores also significantly improved from 39.6 to 57.4 to 89.6 and 22.9, respectively, after surgery. In the MRI evaluation, the T1 rho and T2 values of the implanted area were similar to those of the surrounding cartilage at 52 weeks after implantation. Conclusions: Third generation ACI (IK-01) can be an effective treatment option for focal cartilage defects of the knee; however, surgeons must pay careful attention to the risk of postoperative joint infection.

  Apr. 2022, Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology, 28, 6 - 12, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Protective Effects of Growth Differentiation Factor-6 on the Intervertebral Disc: An In Vitro and In Vivo Study.

  Kunihiko Miyazaki, Shingo Miyazaki, Takashi Yurube, Yoshiki Takeoka, Yutaro Kanda, Zhongying Zhang, Yuji Kakiuchi, Ryu Tsujimoto, Hiroki Ohnishi, Tomoya Matsuo, Masao Ryu, Ryosuke Kuroda, Kenichiro Kakutani

  Growth differentiation factors (GDFs) regulate homeostasis by amplifying extracellular matrix anabolism and inhibiting pro-inflammatory cytokine production in the intervertebral disc (IVD). The aim of this study was to elucidate the effects of GDF-6 on human IVD nucleus pulposus (NP) cells using a three-dimensional culturing system in vitro and on rat tail IVD tissues using a puncture model in vivo. In vitro, Western blotting showed decreased GDF-6 expression with age and degeneration severity in surgically collected human IVD tissues (n = 12). Then, in moderately degenerated human IVD NP cells treated with GDF-6 (100 ng/mL), immunofluorescence demonstrated an increased expression of matrix components including aggrecan and type II collagen. Quantitative polymerase chain reaction analysis also presented GDF-6-induced downregulation of pro-inflammatory tumor necrosis factor (TNF)-α (p = 0.014) and interleukin (IL)-6 (p = 0.016) gene expression stimulated by IL-1β (10 ng/mL). Furthermore, in the mitogen-activated protein kinase pathway, Western blotting displayed GDF-6-induced suppression of p38 phosphorylation (p = 0.041) under IL-1β stimulation. In vivo, intradiscal co-administration of GDF-6 and atelocollagen was effective in alleviating rat tail IVD annular puncture-induced radiologic height loss (p = 0.005), histomorphological degeneration (p < 0.001), matrix metabolism (aggrecan, p < 0.001; type II collagen, p = 0.001), and pro-inflammatory cytokine production (TNF-α, p < 0.001; IL-6, p < 0.001). Consequently, GDF-6 could be a therapeutic growth factor for degenerative IVD disease.

  Mar. 2022, Cells, 11(7) (7), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Advanced glycation end products are associated with limited range of motion of the shoulder joint in patients with rotator cuff tears associated with diabetes mellitus.

  Issei Shinohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Tatsuo Kato, Takahiro Furukawa, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Most degenerative rotator cuff tears (RCTs) are associated with a limited range of motion (ROM) of the shoulder joint. Additionally, patients with diabetes mellitus (DM) show a higher frequency of limited ROM. Recently, advanced glycation end products (AGEs) of proteins have been observed to cause tissue fibrosis, primarily through abnormal collagen cross-linking and oxidative stress. In this study, we investigated the effect of AGEs on ROM limitation in the shoulder capsule and its relationship with DM in the patients with RCTs. METHODS: Sixteen patients (eight in the DM and non-DM groups) who underwent arthroscopic surgery for RCT with limited shoulder ROM were included in this study. AGE-related pathologies in both groups were compared, and the relationship between AGE accumulation and shoulder joint ROM was evaluated. Shoulder capsule tissue was harvested and subjected to histological and in vitro evaluation. RESULTS: The DM group displayed high levels of AGEs and reactive oxygen species (ROS), and reduced cell viability. There was a significant positive correlation between ROS expression, apoptosis, and preoperative hemoglobin A1c. ROS expression, apoptosis, and ROM of the shoulder joint showed a negative correlation. The NADPH oxidase (NOX) expression and collagen III/I ratio were significantly higher in the DM group than in the non-DM group. CONCLUSIONS: The DM group showed significant AGEs deposition in the shoulder capsule. Additionally, there was a significant association between AGEs and ROM limitation. Collectively, the findings suggest that the oxidative stress induced by AGEs deposition, which leads to fibrosis and local inflammation, might contribute to the limited ROM of the shoulder joint in patients with RCTs accompanied by DM.

  Mar. 2022, BMC musculoskeletal disorders, 23(1) (1), 271 - 271, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Safety of 222 nm UVC irradiation to the surgical site in a rabbit model.

  Tomoaki Fukui, Takahiro Niikura, Takahiro Oda, Yohei Kumabe, Aiko Nishiaki, Rena Kaigome, Hiroyuki Ohashi, Masahiro Sasaki, Tatsushi Igarashi, Keisuke Oe, Michael R Hamblin, Ryosuke Kuroda

  For the prevention of surgical site infection (SSI), continuous disinfection could be helpful. Short wavelength ultraviolet radiation C (UVC) is highly bactericidal but shows cytotoxicity. Radiation of UVC with a wavelength of 222 nm to the skin is considered to be safe because it only reaches the stratum corneum. However, the safety of 222 nm irradiation to the surgical field not covered with skin is unknown. The purpose of this study was to examine the safety of 222 nm UVC irradiation on a surgical field in a rabbit model. Five types of tissue were surgically exposed and irradiated with 222 or 254 nm UVC. Immunohistological assessment against cyclobutane pyrimidine dimer (CPD), an index of DNA damage by UVC, was performed. The CPD-positive cell rate was significantly higher in the 254 nm group than in the other groups in all tissues. A 222 nm group showed significantly more CPD than control in fat tissue, but no significant difference in all other tissues. In fat tissue collected 24 h after irradiation, the 254 nm group showed higher CPD than the other groups, while the 222 nm group had reduced to the control level. These data suggest that 222 nm UVC irradiation could be a new method to safely prevent SSI.

  Mar. 2022, Photochemistry and photobiology, 98(6) (6), 1365 - 1371, English, International magazine

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• Antioxidant effect of nicotinamide mononucleotide in tendinopathy.

  Kohei Yamaura, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Shintaro Mukohara, Yuichi Hoshino, Takahiro Niikura, Ryosuke Kuroda

  BACKGROUND: A link between tendinopathy and oxidative stress has been recently reported. Nicotinamide mononucleotide (NMN) is a precursor of nicotinamide adenine dinucleotide, which plays an important role in cell redox homeostasis. The aim of this study was to evaluate the antioxidant effect of NMN on tendinopathy in vitro and in vivo. METHODS: Tenocytes from healthy Sprague-Dawley rats were cultured in regular glucose (RG) and high-glucose (HG) conditions with or without NMN, and were divided into four groups: RG NMN(-), RG NMN(+), HG NMN(-), and HG NMN(+). Cell viability, reactive oxygen species (ROS) accumulation, apoptotic rate, and mRNA expression of nicotinamide adenine dinucleotide phosphate oxidase (NOX)1, NOX4, interleukin (IL)6, sirtuin (SIRT)1, and SIRT6 were investigated. In addition, rats with collagenase-induced tendinopathy were treated with or without NMN. Immunostaining of NOX1 and NOX4; mRNA expression of SIRT1, SIRT6, and IL6; and superoxide dismutase (SOD) activity measurements in the Achilles tendon were performed. RESULTS: NMN increased the expression of SIRT1 and SIRT6 in rat tenocytes, but decreased the levels of NOX1, NOX4, IL6, ROS, and apoptosis. In Achilles tendons with collagenase-induced tendinopathy, NMN increased the mRNA expression of SIRT1 and SIRT6, as well as SOD activity; while suppressing protein expression of NOX1 and NOX4, and mRNA expression of IL6. CONCLUSION: The in vitro and in vivo results of this study show that NMN exerts an antioxidant effect on tendinopathy by promoting the expression of SIRT while inhibiting that of NOX.

  Mar. 2022, BMC musculoskeletal disorders, 23(1) (1), 249 - 249, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Diagnosis of Cubital Tunnel Syndrome Using Deep Learning on Ultrasonographic Images.

  Issei Shinohara, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Tatsuo Kato, Takahiro Furukawa, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  Although electromyography is the routine diagnostic method for cubital tunnel syndrome (CuTS), imaging diagnosis by measuring cross-sectional area (CSA) with ultrasonography (US) has also been attempted in recent years. In this study, deep learning (DL), an artificial intelligence (AI) method, was used on US images, and its diagnostic performance for detecting CuTS was investigated. Elbow images of 30 healthy volunteers and 30 patients diagnosed with CuTS were used. Three thousand US images were prepared per each group to visualize the short axis of the ulnar nerve. Transfer learning was performed on 5000 randomly selected training images using three pre-trained models, and the remaining images were used for testing. The model was evaluated by analyzing a confusion matrix and the area under the receiver operating characteristic curve. Occlusion sensitivity and locally interpretable model-agnostic explanations were used to visualize the features deemed important by the AI. The highest score had an accuracy of 0.90, a precision of 0.86, a recall of 1.00, and an F-measure of 0.92. Visualization results show that the DL models focused on the epineurium of the ulnar nerve and the surrounding soft tissue. The proposed technique enables the accurate prediction of CuTS without the need to measure CSA.

  Mar. 2022, Diagnostics (Basel, Switzerland), 12(3) (3), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Peri-prosthetic bone remodeling of hydroxyapatite-coated compaction short stem was not affected by stem alignment.

  Shinya Hayashi, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Toshihisa Maeda, Takahiro Niikura, Ryosuke Kuroda

  BACKGROUND: To improve implant survival through accelerated early bone remodeling during total hip arthroplasty (THA), hydroxyapatite (HA) is widely used as a bioactive coating, which is believed to enhance initial fixation by osseointegration. We aimed to investigate the relationship between stem insertion alignment and postoperative bone mineral density (BMD) changes in patients with full hydroxyapatite-coated (HA) compaction short stem and short tapered-wedge stem. METHODS: This retrospective cohort study enrolled 115 consecutive patients (115 joints) undergoing THA using the full HA compaction short (n = 59) and short tapered-wedge (n = 56) stems. Stem alignment, including anteversion, valgus, and anterior tilt were measured by a three-dimensional template using computed tomography data. Post-operative peri-prosthetic BMD was measured by dual-energy X-ray absorptiometry. The relationship between stem alignment and BMD changes in the stems was analyzed. RESULTS: Patterns of peri-prosthetic BMD changes were similar in both groups. Stem insertion alignments of anteversion, valgus, and anterior tilt were different between the two stem types. Stem alignment of valgus and anterior tilt did not affect peri-prosthetic BMD in either of the stem type. An absolute anteversion difference between stem anteversion and original canal anteversion caused significant peri-prosthetic BMD loss in Gruen zones one and seven in the tapered-wedge stem. However, stem alignment of absolute anteversion difference did not affect BMD changes in the HA compaction stem. CONCLUSIONS: Peri-prosthetic bone remodeling remained unaffected by stem alignment after THA with the new short full HA compaction stem.

  Mar. 2022, Journal of orthopaedic surgery and research, 17(1) (1), 131 - 131, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• DDHの超音波画像に対する深層学習モデルを用いた画像分類

  衣笠 真紀, 乾 淳幸, 坂田 亮介, 河本 和泉, 小林 大介, 薩摩 眞一, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S931 - S931, Japanese


• 偽関節治療の基礎研究と臨床応用

  新倉 隆宏, 大江 啓介, 福井 友章, 松本 知之, 美舩 泰, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S39 - S39, Japanese


• 非定型大腿骨骨折の病態と治療 非定型大腿骨骨折の病態と疫学

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S469 - S469, Japanese


• 小児整形外科疾患に対する新しい治療法-その展望および問題点- 先天性下腿偽関節症に対するMasquelet法を用いた治療経験

  坂田 亮介, 新倉 隆宏, 薩摩 眞一, 小林 大介, 衣笠 真紀, 八尋 俊輔, 北澤 大也, 福井 友章, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S508 - S508, Japanese


• 高齢大腿骨頸部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について 多施設共同前向き観察研究

  大江 啓介, 新倉 隆宏, 福井 友章, 林 申也, 酒井 良忠, 高原 俊介, 岩倉 崇, 角田 雅也, 柴原 克紀, 正田 悦朗, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S699 - S699, Japanese


• 患者立脚型機能評価を用いた上肢偽関節の治療成績の検討

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S839 - S839, Japanese


• CT有限要素法を用いたreamer irrigator aspirator施行前後の大腿骨強度変化についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S878 - S878, Japanese


• 難治性骨折に対する自家CD34陽性細胞移植 医師主導治験の成果報告

  新倉 隆宏, 大江 啓介, 福井 友章, 松本 知之, 美舩 泰, 川本 篤彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S1027 - S1027, Japanese


• Ewing肉腫におけるslow-cycling cellの同定

  八尋 俊輔, 河本 旭哉, 原 仁美, 竹森 俊幸, 藤原 周一, 北山 和道, 宮本 智弘, 青井 貴之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S113 - S113, Japanese


• 肉腫に対する加速器を用いたホウ素中性子捕捉療法(BNCT)の可能性

  藤本 卓也, 鈴木 実, 田中 浩基, 櫻井 良憲, 高田 卓志, 安藤 徹, 藤田 郁夫, 森下 雅之, 河本 旭哉, 秋末 敏宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S886 - S886, Japanese


• Rectangular taper shortステムとtaper wedge shortステムのTHA術後ステム周囲骨密度変化とステム前捻による影響の比較検討

  安喰 健祐, 林 申也, 藤代 高明, 黒田 雄一, 亀長 智幸, 高島 良典, 中野 直樹, 前田 俊恒, 松本 知之, 平中 崇文, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S233 - S233, Japanese


• 多剤耐性因子MDR1発現がJAK阻害薬治療効果に与える影響の検討

  菊池 健一, 前田 俊恒, 林 申也, 安喰 健祐, 生田 健明, 藤田 雅広, 高島 良典, 橋本 麿和, 積山 賢, 舟橋 恵子, 福田 康治, 黒田 良祐, 松原 司

  (一社)日本リウマチ学会, Mar. 2022, 日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 570 - 570, Japanese


• IL-6阻害薬は骨びらんによる関節破壊の進行を優位に抑制する

  林 申也, 松原 司, 前田 俊恒, 福田 康治, 舟橋 恵子, 橋本 麿和, 積山 賢, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2022, 日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 588 - 588, Japanese


• RA患者由来滑膜線維芽細胞へのIL-6刺激に対するJAK阻害剤の効果の比較検討

  生田 健明, 林 申也, 前田 俊恒, 高島 良典, 菊池 健一, 藤田 雅広, 安喰 健祐, 福田 康治, 積山 賢, 橋本 麿和, 舟橋 恵子, 黒田 良祐, 松原 司

  (一社)日本リウマチ学会, Mar. 2022, 日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 615 - 615, Japanese


• 偽関節治療の基礎研究と臨床応用

  新倉 隆宏, 大江 啓介, 福井 友章, 松本 知之, 美舩 泰, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S39 - S39, Japanese


• 非定型大腿骨骨折の病態と治療 非定型大腿骨骨折の病態と疫学

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S469 - S469, Japanese


• 小児整形外科疾患に対する新しい治療法-その展望および問題点- 先天性下腿偽関節症に対するMasquelet法を用いた治療経験

  坂田 亮介, 新倉 隆宏, 薩摩 眞一, 小林 大介, 衣笠 真紀, 八尋 俊輔, 北澤 大也, 福井 友章, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S508 - S508, Japanese


• 高齢大腿骨頸部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について 多施設共同前向き観察研究

  大江 啓介, 新倉 隆宏, 福井 友章, 林 申也, 酒井 良忠, 高原 俊介, 岩倉 崇, 角田 雅也, 柴原 克紀, 正田 悦朗, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S699 - S699, Japanese


• 患者立脚型機能評価を用いた上肢偽関節の治療成績の検討

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S839 - S839, Japanese


• CT有限要素法を用いたreamer irrigator aspirator施行前後の大腿骨強度変化についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S878 - S878, Japanese


• 難治性骨折に対する自家CD34陽節細胞移植 医師主導治験の成果報告

  新倉 隆宏, 大江 啓介, 福井 友章, 松本 知之, 美舩 泰, 川本 篤彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S1027 - S1027, Japanese


• 整形外科領域の学会統合を考える 整形外科スポーツ学会の現状と今後の在り方

  安達 伸生, 石橋 恭之, 黒田 良祐, 今井 晋二, 出家 正隆

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S2 - S2, Japanese


• Ewing肉腫におけるslow-cycling cellの同定

  八尋 俊輔, 河本 旭哉, 原 仁美, 竹森 俊幸, 藤原 周一, 北山 和道, 宮本 智弘, 青井 貴之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S113 - S113, Japanese


• Co-occurring Acromioclavicular Joint Cyst and Hemarthrosis of the Shoulder Associated With Rotator Cuff Tear Arthropathy.

  Takanobu Higashi, Yutaka Mifune, Hanako Nishimoto, Atsuyuki Inui, Yuichi Hoshino, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda

  Both acromioclavicular joint (ACJ) cysts and hemarthrosis of the shoulder are rare conditions of massive rotator cuff tear that eventually lead to cuff tear arthropathy. We herein report the first case of a patient with co-occurring ACJ cyst and hemarthrosis of the shoulder. An 80-year-old right-hand-dominant man presented to our outpatient department with a six-month history of repeatable right shoulder pain and swelling. Clinical examination revealed a 5 x 5 x 5 cm elastic hard or hard shoulder lump overlying the ACJ on skin with subcutaneous bleeding and swelling of the shoulder. Shoulder pain at rest and a fully reduced active range of motion (ROM), particularly in flexion and abduction, were also noted. Radiographs demonstrated moderate degeneration of the glenohumeral joint including a bone cyst of the humeral head. Magnetic resonance imaging (MRI) revealed a massive rotator cuff tear with atrophy of the supraspinatus, infraspinatus, and subscapularis muscles. The T2-weighted MRI images showed that the cyst was in direct contact with the markedly degenerated glenohumeral joint. Based on these findings, the patient was diagnosed with massive rotator cuff tear with ACJ cyst and hemarthrosis of the shoulder. The patient underwent distal clavicle resection and reverse total shoulder arthroplasty (RSA). At 12-month follow-up, the patient showed no pain symptoms, no recurrence of the cyst, and excellent ROM. We experienced a very rare case of ACJ cyst and hemarthrosis of the shoulder occurring simultaneously with rotator cuff tear arthropathy. This report is very valuable in that it suggests that RSA is useful for both ACJ cysts and hemarthrosis of the shoulders associated with rotator cuff tear arthropathy.

  Mar. 2022, Cureus, 14(3) (3), e23353, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Continuous Local Antibiotic Perfusion (CLAP) for Post-operative Infection of Open Tibial Fractures: A Case Report.

  Ryowa Mineo, Keisuke Oe, Takahiro Niikura, Hirotsugu Muratsu, Ryosuke Kuroda, Akihiro Maruo

  INTRODUCTION: We encountered a case of post-operative infection of an open tibial fracture that was controlled by continuous local antibiotic perfusion (CLAP), a novel method of fracture-related infection (FRI) that we have developed. CLAP is a procedure in which a bone marrow needle and a double lumen tube are placed in the infected area, and an appropriate concentration of antimicrobial agent is continuously administered and perfused. CASE REPORT: The patient was a 78-year-old woman. She was hit by a motor vehicle and fell to the farmyard floor. She suffered multiple traumas, including a lower leg open fracture, multiple rib fractures, clavicle fracture, pelvic fracture, mandibular fracture, and liver injury. Her tibial fracture was a Gustilo-Anderson type IIIA open fracture. After debridement and external fixation of the tibial open fracture on the same day, open reduction and internal fixation with an intramedullary nail was performed 3 days after the injury. Twelve days after the injury, local heat and redness were observed at the nail insertion wound and the posteromedial calf, and a purulent clot was discharged from the open wound. We performed curettage of the lesion and retained the implant. CLAP was then constructed to perfuse local antibiotics along the nail and large hematoma area. Locally, the inflammation improved and the inflammatory response became negative 3 weeks after the initiation of CLAP. Six months after surgery, bony union was achieved. At present, 3.5 years after the internal operation, there is no sign of infection, and the patient has returned to her pre-injury life with no abnormalities in motor function. CONCLUSION: CLAP may be a novel treatment method that can be expected to achieve bone healing while preserving the implant in FRI cases after open tibial fracture.

  Feb. 2022, Journal of orthopaedic case reports, 12(2) (2), 18 - 22, English, International magazine


• TresLock for Unstable Proximal Femoral Fractures: Morphological Compatibility and Clinical Results: A Case Series.

  Ryo Yoshikawa, Takafumi Hiranaka, Tomoyuki Kamenaga, Takahiro Niikura, Yoshitada Sakai, Ryosuke Kuroda

  INTRODUCTION: A new device, TresLock (KISCO DIR Co., Ltd., Kobe), has been used for the treatment of unstable proximal femoral fractures and was designed based on Japanese anatomical characteristics. It has three sliding hip screws with one side plate. The angle of all screws relative to the plate has been set to 128°, and each hip screw has a short thread (15 mm) to prevent crossing of the fracture line. In this study, we evaluated the morphological compatibility of TresLock. METHODS: We treated 10 patients with hip fractures using TresLock at our institution between September 2016 and December 2017. The average age of the patients was 83.8 years (range, 73-93 years). Fractures included five proximal neck transcervical shear fractures (Orthopaedic Trauma Association [OTA] type-31B2.3, Pauwels III) and five basicervical fractures (OTA type-31B3). The clinical course and three-dimensional computed tomography were evaluated postoperatively. RESULTS: In all cases, all three screws were inserted within the femoral neck. The screws were inserted at an axis of 2.5 ± 1.3° varus to the femoral neck axis. The distance from the subcapital line to the three (proximal-anterior, proximal-posterior, and distal) screw thread ends was 12.0 ± 1.8 mm, 10.4 ± 2.4 mm, and 11.6 ± 4.0 mm, respectively and was sufficient to actuate compression force. However, one case (Pauwels III) required reoperation because of non-union. CONCLUSION: Careful follow-up is needed, but TresLock shows good anatomical compatibility for femurs among the Japanese population.

  Feb. 2022, Journal of orthopaedic case reports, 12(2) (2), 49 - 52, English, International magazine


• Endochondral Bone Tissue Engineering Using Human Induced Pluripotent Stem Cells.

  Michio Arakura, Sang Yang Lee, Tomoaki Fukui, Keisuke Oe, Shunsuke Takahara, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  The use of induced pluripotent stem cells (iPSCs) shows potential in bone regenerative strategies. In this study, we investigated whether implantation of chondrogenically differentiated iPSC-derived mesenchymal stem cells (iMSCs) can lead to successful bone regeneration in nude mice with bone defects. Two human iPSC clones (201B7 and 454E2) were used. After generating iMSCs, chondrogenic differentiation was achieved by three-dimensional pellet culture. Thereafter, a 2-mm defect was created in the radius of nude mice, and chondrogenically differentiated iMSC pellets were transplanted in the defect. Microcomputed tomography imaging was performed 8 weeks posttransplantation to assess bone regeneration. All (100%) radii in the 201B7 cell-derived pellet transplantation group and 7 of 10 (70%) radii in the 454E2 cell-derived pellet transplantation group showed bone union. In contrast, 2 of 11 radii (18%) in the control group showed bone union. Thus, the experimental groups showed significantly higher bone union rates than the control group (p < 0.05). Histological analysis 2 weeks postimplantation in the experimental groups revealed hypertrophic chondrocytes within grafted iMSC pellets and the formation of woven bone around them. This hypertrophic chondrocyte transitioning to newly formed bone suggests that the cartilaginous template can trigger endochondral bone ossification (ECO). Four weeks postimplantation, the cartilage template was reduced in size; newly formed woven bone was predominant in the defect site. New vessels were surrounded by a matrix of woven bone, and hypertrophic chondrocytes transitioning to newly formed bone indicated the progression of ECO. Eight weeks postimplantation, the pellets were completely resorbed and replaced by bone; complete bone union was observed. Dense mature bone developed with evidence of lamellar-like bone formation. Collectively, our results suggest that using iMSC-based cartilage grafts recapitulating the morphogenetic process of ECO in the context of embryonic skeletogenesis is a promising strategy for repairing large bone defects. Impact statement We investigated whether implantation of chondrogenically differentiated iPSC-derived mesenchymal stem cells (iMSCs) could lead to the successful regeneration of bone defects in vivo. We implanted two different clones of human induced pluripotent stem cells into a radial bone defect model. Eleven of 11 (100%) and 7 of 10 (70%) radii in the 201B7 and 454E2 cell-derived pellet transplantation groups, respectively, showed bone union, which were significantly higher than those in the control group [only 2 of 11 radii (18%)]. Overall, our results support the use of iMSC-based cartilage grafts recapitulating the morphogenetic process of endochondral bone ossification for repairing large bone defects.

  Feb. 2022, Tissue engineering. Part A, 28(3-4) (3-4), 184 - 195, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Combination of Anterior Acetabular Coverage and Femoral Head Shape Predicts Femoroacetabular Impingement After Periacetabular Osteotomy.

  Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Ryosuke Kuroda

  BACKGROUND: Femoroacetabular impingement (FAI) after periacetabular osteotomy (PAO) may be affected by both anterior acetabular coverage and femoral head shape. This study aimed to radiographically evaluate the relationship of the combination of acetabular coverage and femoral head shape with the occurrence of FAI after curved PAO. METHODS: In this study, 76 hip joints from patients with symptomatic developmental dysplasia of the hip underwent curved PAO. The relationship between the combined postoperative anterior center-edge and alpha angles (ie, the combination angle) and the occurrence of postoperative FAI was evaluated. Clinical factors and the preoperative and postoperative 3-dimensional center-edge angles, acetabular versions, femoral versions, radiographic alpha angles of the femoral head, and the combination angle were measured and compared to clinical outcomes. RESULTS: The modified Harris Hip Scores, University of California, Los Angeles activity scores, and acetabular coverage angles were significantly improved following curved PAO. Receiver operator characteristic curve analysis demonstrated that the combination angle over 108° may be a predictive factor for the occurrence of FAI after curved PAO. Multivariate analysis demonstrated that an age <40 years (odds ratio 6.6, 95% confidence interval 1.2-36.4, P = .037) and a combination angle <108° (odds ratio 9.2, 95% confidence interval 1.7-50.0, P = .010) were significantly associated with modified Harris Hip Scores ≧90 points. CONCLUSION: A combination angle >108° may be a predictive factor for the occurrence of FAI after curved PAO and impaired clinical outcomes. To avoid postoperative FAI, we propose that osteochondroplasty of the femoral head should be performed for patients with preoperative combination angles >90°.

  Feb. 2022, The Journal of arthroplasty, 37(2) (2), 219 - 225, English, International magazine

  Scientific journal


• Low-Intensity Pulsed Ultrasound Promotes Osteogenic Differentiation of Reamer-Irrigator-Aspirator Graft-Derived Cells in Vitro.

  Kenichi Sawauchi, Tomoaki Fukui, Keisuke Oe, Yohei Kumabe, Takahiro Oda, Ryo Yoshikawa, Kyohei Takase, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  Recently, reamer-irrigator-aspirator (RIA) systems have been increasingly used to harvest autologous bone grafts. RIA graft materials contain bone marrow, which provides a viable source to derive large numbers of mesenchymal stem cells. Low-intensity pulsed ultrasound (LIPUS) significantly accelerates the differentiation of stem cells derived from bone marrow. This in vitro study investigated the effect of LIPUS on the osteogenic activity and differentiation of RIA graft-derived cells. A small amount of RIA graft was obtained from seven patients. After the cells derived from RIA grafts were cultured, they were divided into two groups: the LIPUS and control groups. LIPUS was applied once daily for 20 min (1.5 MHz, pulse duration: 200 µs, pulse repetition rate: 1 kHz, spatial average-temporal average intensity: 30 mW/cm2). Alkaline phosphatase activity (113.4% and 130.1% on days 7 and 14), expression of osteoblast-related genes (ALP, Runx2) and mineralization (135.2% on day 21) of the RIA graft-derived cells were significantly higher in the LIPUS group than in the control group. However, LIPUS did not affect the cell proliferation of RIA graft-derived cells. This study indicates that LIPUS may enhance the healing of non-union and critical bone defects treated by autologous bone grafting using the RIA system.

  Feb. 2022, Ultrasound in medicine & biology, 48(2) (2), 313 - 322, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Preoperative Evaluation of Thenar Muscles in Carpal Tunnel Syndrome by Ultrasonography.

  Issei Nagura, Takako Kanatani, Yoshifumi Harada, Fumiaki Takase, Atsuyuki Inui, Yutaka Mifune, Ryosuke Kuroda

  This article aims to evaluate the usefulness of ultrasonography for the measurement of thenar muscles in carpal tunnel syndrome (CTS). A total of 85 patients with CTS who had a carpal tunnel release procedure were included in this study. The transducer was applied onto the palmar surface of the hand perpendicularly to the longitudinal axis of the first metacarpal bone. Thenar atrophy was evaluated visually and classified using the visual grading scale. A nerve conduction test was performed and classified according to the electrophysiological severity scale. This technique is more precise than visual evaluation because it is a quantitative assessment.

  Feb. 2022, Hand clinics, 38(1) (1), 55 - 58, English, International magazine

  Scientific journal


• Patients' Characteristics Can Predict Clinical Outcomes Following Hip Arthroscopy by Reflecting the Patterns of Labral Tears: A Retrospective Observational Study.

  Nobuaki Chinzei, Shingo Hashimoto, Shinya Hayashi, Naoki Nakano, Masahiko Haneda, Yuichi Kuroda, Tomoyuki Matsumoto, Ryosuke Kuroda

  PURPOSE: To evaluate the relationship between morphological differences in labral tears and clinical features of the hip joint in patients who underwent hip arthroscopy. MATERIALS AND METHODS: We retrospectively analyzed data from patients who underwent arthroscopic surgery for the treatment of labral tears. Hip labral tears were morphologically classified as longitudinal peripheral tears (group L), radial fibrillated tears (group FI), radial flaps (group FL), and an unstable labrum (group U). Radiographically, the center-edge angle, acetabular roof obliquity, vertical-center-anterior angle, alpha angle, femoral head-neck offset ratio, and crossover sign were evaluated and compared among the groups. The relationship between labral morphology and these radiographic findings, as well as clinical findings, such as age, gender, preoperative range of hip motion, and the clinical outcomes using modified Harris Hip Score (mHHS) were also examined. RESULTS: This study included fifty patients. Groups L and FI were often observed in late middle-aged patients with relatively shallow acetabular coverage. Group FL tears were frequently observed in young males with radiographic features, such as femoroacetabular impingement (FAI), compared to the other groups. Group U comprised mostly young females with relatively shallow acetabular coverage compared to the other groups. For the postoperative mHHS, group FL showed the best score among all groups, with a significant difference between groups FL and FI (p = 0.034). CONCLUSIONS: Our study revealed that morphologically, different labral tears were associated with different clinical features and radiological findings. Especially, our study can provide predictive findings for hip arthroscopists that younger males with FAI show better clinical outcomes when compared to middle-aged females with shallow acetabulum, which is indicative of degenerative hip labral tears. LEVEL OF EVIDENCE: IV case series.

  Feb. 2022, Indian journal of orthopaedics, 56(2) (2), 295 - 302, English, International magazine

  Scientific journal


• Accuracy and reliability of tridimensional electromagnetic sensor system for elbow ROM measurement.

  Kohei Yamaura, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takeshi Kataoka, Takashi Kurosawa, Shintaro Mukohara, Yuichi Hoshino, Takahiro Niikura, Kouki Nagamune, Ryosuke Kuroda

  BACKGROUND: While the precise measurement of the range of motion (ROM) of the elbow joint is important for clinical assessment and rehabilitation, problems include low accuracy and reproducibility in goniometer measurements due to the influence of soft tissue. The purpose of this study was to validate elbow joint motion analysis using a three-dimensional electromagnetic sensor system (EMS). METHODS: The accuracy and reproducibility of the EMS system were evaluated at four angles (0°, 45°, 90°, and 135°) using a model bone of the humerus and forearm. In addition, the maximum extension and maximum flexion of six elbows of six healthy volunteers were assessed by radiographic and EMS measurements. Accuracy was assessed by calculating the mean value of the measurement angle, standard deviation, Pearson's correlation coefficient, and the Bland-Altman method. Reproducibility was assessed by calculating the intra-rater and inter-rater reliabilities using intraclass correlation coefficients. RESULTS: In the model bone evaluation, the mean angles of the EMS measurement were 1.2° ± 2.0°, 45.4° ± 2.1°, 91.7° ± 2.4°, and 134.6° ± 2.7° at 0°, 45°, 90°, and 135°, respectively. In the in vivo evaluation, the elbow angles at the maximum extension with the EMS and radiographic angles were 4.7° ± 3.0° and 2.7° ± 2.0°, respectively, and the angles at maximum flexion were 131.8° ± 13.0° and 130.8° ± 4.5°, respectively. There were statistically significant correlations between the EMS and radiographic measurements; the Bland-Altman plots indicated that the two methods were almost in agreement for both extension and flexion. CONCLUSIONS: This method of measuring ROM of the elbow joint using EMS showed high accuracy, reliability, and reproducibility. The current results demonstrated the possibility of using the electromagnetic system to provide an accurate evaluation of the elbow joint in clinical settings.

  Jan. 2022, Journal of orthopaedic surgery and research, 17(1) (1), 60 - 60, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle.

  Issei Shinohara, Takeshi Kataoka, Yutaka Mifune, Atsuyuki Inui, Ryosuke Sakata, Hanako Nishimoto, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Tatsuo Kato, Takahiro Furukawa, Takehiko Matsushita, Ryosuke Kuroda

  Tendon rupture and nerve injury cause fatty infiltration of the skeletal muscle, and the adipokines secreted from the infiltrated adipocytes are known to contribute to chronic inflammation. Therefore, in this study, we evaluated the effects of the adipokines on chronic inflammation using a rat sciatic nerve-crushed injury model. In vitro and in vivo experiments showed that the expression of adiponectin was decreased (0.3-fold) and the expression of Il6 (~ 3.8-fold) and Tnf (~ 6.2-fold) was increased in the nerve-crushed group compared to that in the control group. It was also observed that the administration of an adiponectin receptor agonist decreased the levels of Il6 (0.38-fold) and Tnf (0.28-fold) and improved cellular viability (~ 1.9-fold) in vitro. Additionally, in the fatty infiltrated skeletal muscle, low adiponectin levels were found to be associated with chronic inflammation. Therefore, the local administration of adiponectin receptor agonists would prevent chronic inflammation.

  Jan. 2022, Scientific reports, 12(1) (1), 1557 - 1557, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Histopathological changes of synovial tissue in rheumatoid arthritis patients treated with TNF-α inhibitors or IL-6 inhibitors.

  Yoshinori Takashima, Shinya Hayashi, Toshihisa Maeda, Koji Fukuda, Yuma Onoi, Syotaro Tachibana, Kemmei Ikuta, Kensuke Anjiki, Masahiro Fujita, Kenichi Kikuchi, Tomoyuki Kamenaga, Ryosuke Kuroda, Tsukasa Matsubara

  OBJECTIVES: To investigate the cell types that undergo apoptosis in TNF-α inhibitor (TNFI)- and IL-6 inhibitor (IL-6I)-treated synovia of RA patients, and to observe and compare histological changes in them. METHODS: Synovial tissue was collected during total knee arthroplasty from 20 RA patients who were divided into three groups based on RA treatment received: conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs, control group), TNFI, or IL-6I. Tissue samples were subjected to haematoxylin and eosin staining, terminal deoxynucleotidyl transferase fluorescein-deoxyuridine triphosphate nick end labelling (TUNEL), immuno-histochemistry (IHC) and immunofluorescence staining for, respectively, histopathological assessment, apoptosis detection and IHC evaluation and scoring. RESULTS: TUNEL-positive cells were detected surrounding the discoid fibrosis unique to the TNFI group, while those in the IL-6I group were distributed widely, especially surrounding the blood vessels. IHC revealed that in TNFI-treated tissue, CD86- and CD80-positive cells were detected only in the lining and sublining layer, while CD163- and CD206-positive cells were detected more broadly; in the IL-6I-treated tissue, all four were detected widely but their levels were lower than in the control group. Immunofluorescence also revealed macrophages mainly were the apoptotic cells in the lining and sublining layers of TNFI group. TUNEL Expression levels of CD20- and CD3-positive cells were remarkably lower in the IL-6I group, compared with the control and TNFI groups. CONCLUSIONS: TNFIs and IL-6Is target different action sites and synovial cell types, resulting in histopathological features of synovium distinct from one another.

  Jan. 2022, Clinical and experimental rheumatology, English, International magazine

  Scientific journal


• Fully hydroxyapatite-coated compaction broached and triple-tapered stem may reduce the risk of stress shielding after primary total hip arthroplasty.

  Yuichi Kuroda, Shingo Hashimoto, Shinya Hayashi, Naoki Nakano, Takaaki Fujishiro, Takafumi Hiranaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: Changes in bone mineral density (BMD) around the fully hydroxyapatite (HA)-coated compaction broached and triple-tapered stem, namely, Polarstem, after total hip arthroplasty (THA) are currently unknown. Therefore, the aims of this study were to investigate clinical outcomes of Polarstem, mainly postoperative temporal changes in BMD around the stem for 2 years, and to compare them with those of HA-coated and non-HA-coated tapered-wedge stems. METHODS: This retrospective cohort study enrolled 100 consecutive patients who underwent THA using Polarstem (n = 38), HA-coated Anthology (n = 31), and non-HA-coated Anthology (n = 31). BMD was evaluated using dual-energy X-ray absorptiometry in seven regions according to the Gruen zones. Postoperatively, BMD around the stem was assessed within 2 months (baseline BMD) and at 6, 12, and 24 months. A change in BMD was defined as the value calculated by dividing each postoperative BMD value at 6, 12, and 24 months by the baseline BMD value. Changes in BMD and radiographic parameters such as stress shielding and spot welds were compared among the three stems. RESULTS: The incidence rate of stress shielding in the Polarstem group was significantly lower than those in the other two groups (p = 0.007). The change in BMD in Zone 7 of Polarstem was significantly more than that of the other two groups at 12 and 24 months postoperatively (p = 0.030 and p = 0.009, respectively). CONCLUSION: Polarstem, a fully HA-coated compaction broached and triple-tapered stem, maintained BMD around the femoral calcar until 2 years postoperatively and could reduce the risk of stress shielding compared with tapered-wedge stems.

  Jan. 2022, Archives of orthopaedic and trauma surgery, 142(12) (12), 4087 - 4093, English, International magazine

  Scientific journal


• Anterior acetabular coverage and femoral head-neck measurements predict postoperative anterior impingement: A simulation study.

  Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Ryosuke Kuroda

  The aim of this simulation study was to evaluate the relationship of elements of anterior acetabular coverage and femoral head-neck shape with the occurrence of postoperative anterior impingement after curved periacetabular osteotomy (PAO). Sixty-two patients with symptomatic developmental dysplasia of the hip who had undergone curved PAO were selected. The likelihood of developing postoperative anterior impingement was explored through simulations of the range of motion by collision detection of the pelvis and femur. Postoperative anterior impingement was defined as impingement that occurred during postoperative bone flexion <105° or postoperative internal rotation <20° at 90° flexion. The three-dimensional center-edge (CE) angles, acetabular and femoral versions, radiographic alpha angles of the femoral head, combination angles of anterior CE and alpha angles, and combined anteversions of acetabular and femoral versions were compared between patients with postoperative anterior impingement and nonimpingement. A receiver operator characteristic (ROC) analysis was conducted to determine thresholds of the examined radiographic parameters and calculate their accuracy for predicting postoperative anterior impingement. A multivariate analysis was performed to test whether combined anteversion, anterior CE angle, and combination angle are associated with excellent modified Harris Hip Scores (mHHSs). ROC analysis demonstrated a combination angle ≥108° was predictive of the occurrence of postoperative anterior impingement after curved PAO, which can lead to impaired clinical outcomes. Conversely, a combination angle <108° was significantly associated with mHHS ≥ 90 points. To avoid postoperative anterior impingement, osteochondroplasty of the femoral head or anterior CE angle control should be performed for patients with preoperative combination angles ≥90°.

  Jan. 2022, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, English, International magazine

  Scientific journal


• Immunohistochemical analysis revealed the expression of bone morphogenetic proteins-4, 6, 7, and 9 in human induced membrane samples treated with the Masquelet technique.

  Takahiro Niikura, Takahiro Oda, Naoe Jimbo, Masato Komatsu, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Tomoo Itoh, Ryosuke Kuroda

  BACKGROUND: Induced membrane (IM) is the key component of Masquelet reconstruction surgery for the treatment of bone defects. IM is formed around the cement spacer and is known to secrete growth factors and osteoinductive factors. However, there is limited evidence available concerning the presence of osteoinductive factors in IM. This study aimed to investigate the existence of bone morphogenetic proteins (BMPs) in IM harvested from patients during the treatment of bone defects using the Masquelet technique. METHODS: This study involved six patients whose bone defects had been treated using the Masquelet technique. The affected sites were the femur (n = 3) and the tibia (n = 3). During the second-stage surgery, 1 cm2 pieces of IM were harvested. Histological sections of IM were immunostained with anti-BMP-4, 6, 7, and 9 antibodies. Human bone tissue served as the positive control. RESULTS: The presence of BMP-4, 6, 7, and 9 was observed in all IM samples. Further, immunolocalization of BMP-4, 6, 7, and 9 was observed in blood vessels and fibroblasts in all IM samples. Immunolocalization of BMP-4, 6, 7, and 9 was also observed in bone tissue within the IM in one sample, in which osteogenesis inside the IM was observed. CONCLUSIONS: This study showed that osteoinductive factors BMP-4, 6, 7, and 9 were present in the IM harvested from patients, providing evidence indicating that the Masquelet technique effectively contributes to healing large bone defects. Therefore, it may be possible for surgeons to omit the addition of BMPs to bone grafts, given the endogenous secretion of BMPs from the IM.

  Jan. 2022, Journal of orthopaedic surgery and research, 17(1) (1), 29 - 29, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Improved Accuracy and Safety of Pedicle Screw Placement by Using a Probe with an Electrical Conductivity-Measuring Device during Severe Syndromic and Neuromuscular Scoliosis Spine Surgery.

  Takashi Yurube, Yutaro Kanda, Masaaki Ito, Yoshiki Takeoka, Teppei Suzuki, Koki Uno, Ryosuke Kuroda, Kenichiro Kakutani

  An electrical conductivity-measuring device (ECD) has recently been developed to support pedicle screw placement. However, no evidence exists regarding its efficacy for syndromic/neuromuscular scoliosis with extremely difficult screwing. We retrospectively reviewed 2010-2016 medical records of 21 consecutive syndromic/neuromuscular scoliosis patients undergoing free-hand segmental fixation surgery at our institution and compared the pedicle screw insertion accuracy and safety between 10 with a conventional non-ECD probe (2010-2013) and 11 with an ECD probe (2014-2016). We analyzed preoperative pedicle shape and postoperative screw placement in computed tomography. There were no significant differences between ECD and non-ECD groups in demographic, clinical, and treatment characteristics including scoliosis severity and pedicle diameter. The abandonment rate due to liquorrhea or perforation was lower in ECD (12.3%) than in non-ECD (26.7%) (p < 0.01). Acceptable insertion without perforation or <2-mm lateral/cranial position was more frequent in ECD (67.1%) than in non-ECD (56.9%) (p = 0.02). Critical ≥5-mm medial/caudal malposition was not seen in ECD (0.0%) but in non-ECD (2.4%) (p = 0.02). The perforation distance was shorter in ECD (2.2 ± 1.1 mm) than in non-ECD (2.6 ± 1.7 mm) (p = 0.01). Results involve small sample size, selection, performance, and learning curve biases; nevertheless, ECD could be useful for more accurate and safer pedicle screw placement in severe syndromic/neuromuscular scoliosis.

  Jan. 2022, Journal of clinical medicine, 11(2) (2), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Motion Analysis of Triangular Fibrocartilage Complex by Using Ultrasonography Images: Preliminary Analysis.

  Issei Shinohara, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Tatsuo Kato, Takahiro Furukawa, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  The triangular fibrocartilage complex (TFCC) is a significant stabilizer of the distal radioulnar joint. Diagnosing TFCC injury is currently difficult, but ultrasonography (US) has emerged as a low-cost, minimally invasive diagnostic tool. We aimed to quantitatively analyze TFCC by performing motion analysis by using US. Twelve healthy volunteers, comprising 24 wrists (control group), and 15 patients with TFCC Palmer type 1B injuries (injury group) participated. The US transducer was positioned between the ulnar styloid process and triquetrum and was tilted ulnarly 30° from the vertical line. The wrist was then actively moved from 10° of radial deviation to 20° of ulnar deviation in a 60-rounds-per-minute rhythm that was paced by a metronome. The articular disc displacement velocity magnitude was analyzed by using particle image velocimetry fluid measurement software. The mean area of the articular discs was larger on ulnar deviation in the control group. The mean articular disc area on radial deviation was larger in the injury group. The average articular disc velocity magnitude for the injury group was significantly higher than that for the control group. The results suggest that patients with TFCC injury lose articular disc cushioning and static stability, and subsequent abnormal motion can be analyzed by using US.

  Jan. 2022, Sensors (Basel, Switzerland), 22(1) (1), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 膝前十字靱帯再建術後3ヵ月時点のACL-RSI scaleと術後2年以内の再損傷の関連

  上田 雄也, 松下 雄彦, 柴田 洋平, 三浦 大祐, 瀧口 耕平, 小野 くみ子, 木田 晃弘, 長井 寛斗, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (一社)日本スポーツ理学療法学会, 2022, スポーツ理学療法学, 2(Suppl.) (Suppl.), OS - 02, Japanese


• Continuous local antibiotic perfusion: A treatment strategy that allows implant retention in fracture-related infections.

  Akihiro Maruo, Takahiro Oda, Ryowa Mineo, Hidetoshi Miya, Hirotsugu Muratsu, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Takahiro Niikura

  PURPOSE: Fracture-related infections are difficult to treat because of the formation of biofilms around implants. Systemic antibiotics are notoriously ineffective against biofilms due to their insufficient penetration of tissues with poor vascularity. The goal of treating fracture-related infections is to achieve bone union while retaining the implant. Our proposal of continuous local antibiotic perfusion is a sustained local delivery system of sufficient antibiotics to bone and soft tissue infection sites, including to bone marrow via needles as intra-medullary antibiotics perfusion and to soft-tissue via double-lumen subcutaneous tubes as intra-soft tissue perfusion. METHODS: In this study, we examined the outcomes of 40 patients treated for fracture-related infections using continuous local antibiotic perfusion between 2015 and 2021 at Steel Memorial Hirohata Hospital, Himeji, Japan. RESULT: The antibiotic used for continuous local antibiotic perfusion was gentamicin in all cases. Implant removal was required in five patients. Two patients required toe amputation and knee arthrodesis, while the remaining 38 patients achieved fracture union. Only one case of transient acute renal injury as a systemic side effect was observed, but it soon resolved. The blood concentration of gentamicin could be adjusted to less than the trough level. CONCLUSIONS: Continuous local antibiotic perfusion is a novel local drug delivery system that has the potential of delivering sufficient concentrations of antibiotics with few systemic side effects; it is a useful option for the treatment of fracture-related infections.

  2022, Journal of orthopaedic surgery (Hong Kong), 30(2) (2), 10225536221111902 - 10225536221111902, English, International magazine

  Scientific journal


• A genome-wide association study identifying single nucleotide polymorphisms in the PPFIBP2 gene was predictive for interstitial lung disease in rheumatoid arthritis patients.

  Shinya Hayashi, Tsukasa Matsubara, Koji Fukuda, Toshihisa Maeda, Keiko Funahashi, Marowa Hashimoto, Yoshinori Takashima, Kenichi Kikuchi, Masahiro Fujita, Tomoyuki Matsumoto, Ryosuke Kuroda

  OBJECTIVE: Genetic polymorphisms might serve as useful prognostic markers for the timely diagnosis of RA. The purpose of this study was to identify genomic factors predictive of the occurrence of interstitial lung disease (ILD) in RA by performing a genome-wide association study of genetic variants, including single nucleotide polymorphisms (SNPs). METHODS: The study population included 306 RA patients. All patients were treated with conventional DMARDs, including 6-16 mg MTX per week. Clinical data and venous blood samples were collected from all patients before administration of DMARDs. A total of 278 347 SNPs were analysed to determine their association with ILD occurrence. RESULTS: Several SNPs were strongly associated with ILD occurrence (P < 10-5). rs6578890, which is located on chromosome 11 in the intronic region of the gene encoding tyrosine phosphatase receptor type F polypeptide-interacting protein-binding protein 2 (PPFIBP2), showed the strongest association with ILD occurrence (odds ratio 4.32, P = 10-7.93). CONCLUSION: PPFIBP2 could be a useful genetic marker for occurrence of interstitial pneumonia in RA patients and might help to identify the risk of ILD occurrence before RA treatment, thereby improving patient outcomes.

  2022, Rheumatology advances in practice, 6(3) (3), rkac088, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Simulation Of Bone Fracture Healing Process Using Ultrasound And BMD Data.

  Takumi Ueyama, Yohei Kumabe, Keisuke Oe, Tomoaki Fukui, Takahiro Niikura, Ryosuke Kuroda, Masakazu Morimoto, Naomi Yagi, Yutaka Hata

  2022, ICMLC, 259 - 264

  International conference proceedings


• Clinical Outcomes and Prognostic Factors in Soft Tissue Sarcoma Patients After Unplanned Excision.

  Toshiyuki Takemori, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Yutaka Mifune, Yuichi Hoshino, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue

  Purpose: Soft tissue sarcomas (STSs) constitute a group of rare, heterogeneous tumors representing approximately 1% of all cancers. Owing to the rarity and pathological diversity of the disease, unplanned excision (UE) has often been performed for STS, resulting in an unfavorable prognosis. This study aimed to clarify clinical outcomes and prognostic factors in STS patients who underwent UE. Patients and Methods: In a retrospective review of the medical records of patients with STS who underwent surgery at our institution between 1999 and 2015, patients were enrolled to either a UE group or a planned excision (PE) group. An analysis was then conducted to identify factors associated with prognosis after UE. Results: Of 134 patients undergoing surgery for STS, 110 were enrolled to the PE group and 24 to the UE group. The median size of the primary tumor was significantly smaller, and more lesions were located in the superficial layer in the UE group than in the PE group. In addition, plastic reconstruction after additional radical resection was required significantly more often in the UE group than in the PE group. No significant difference in overall survival, local recurrence-free survival, or disease-free survival (DFS) between the UE and PE groups was observed; however, metastasis-free survival was significantly better in the UE group. In the UE group, poorer DFS was associated with older age (≥61 years) and a larger primary tumor (≥2.9 cm). Conclusion: A prognosis similar to that in patients undergoing PE could be achieved by appropriate additional surgeries in patients initially undergoing UE. However, UE for STS should be avoided, especially in older patients and those with a larger primary tumor.

  2022, Cancer management and research, 14, 1815 - 1824, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Proximal-type epithelioid sarcoma in pubic region expressing L-type amino acid transporter 1: A case report.

  Shunsuke Yahiro, Takuya Fujimoto, Ikuo Fujita, Toshihiro Takai, Toshiko Sakuma, Tamotsu Sudo, Masayuki Morishita, Shunsaku Takigami, Teruya Kawamoto, Hitomi Hara, Toshihiro Akisue, Ryosuke Kuroda, Takanori Hirose

  Proximal-type epithelioid sarcoma is an aggressive malignant soft-tissue neoplasm, a "proximal" variant of epithelioid sarcoma, resistant to multimodal therapy and involved in early tumor-related death. Pertinent treatments are, therefore, continually being explored. A 24-year-old woman with nonmetastatic proximal-type epithelioid sarcoma, originating subcutaneously on the right side of the vulva, underwent surgical resection; the lesion recurred, however, leading to death 3 months after the second surgery. Here described is a case of proximal-type epithelioid sarcoma expressing L-type amino acid transporter 1 (LAT1) that transports essential amino acids and p-borono-L-phenylalanine (BPA)-the chemical compound used in boron neutron capture therapy (BNCT)-and is highly expressed in many malignant tumors. Recently, LAT1 has drawn attention, and relevant treatments have been studied-LAT1 inhibitor and BNCT. LAT1 expression in proximal-type epithelioid sarcoma may lead to cogent treatments for the disease.

  2022, SAGE open medical case reports, 10, 2050313X211067917, English, International magazine


• A Case of Nonunion with Ballooning Deformity after Periprosthetic Humeral Fracture.

  Yutaka Matsumiya, Keisuke Oe, Tomoaki Fukui, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Introduction: We report a very rare case of nonunion with ballooning deformity of the humeral bone after a periprosthetic humeral fracture nonunion. Case Report: A 79-year-old woman underwent hemiarthroplasty 19 years ago for her proximal humerus fracture. She injured her right humeral diaphysis (stem distal end fracture) 6 years ago. She underwent revision hemiarthroplasty with long stem, but bony union was not obtained, and her right upper limb function was subsequently abolished due to extreme instability and pain in her right upper arm. She was then referred to our hospital for further treatment. X-ray showed nonunion in the humeral diaphysis and a severe ballooning deformity in the distal humeral bone fragment. Due to the advanced age and low activity of the patient, we chose total humerus replacement surgery instead of osteosynthesis. After the surgery, her upper arm pain and instability immediately improved. Three years after the last surgery, there have been no implant failures, and the upper arm is stable and painless. Conclusion: Although there are some reports of total humerus replacement as surgical treatment for humeral tumor and severe periprosthetic fracture, we found no reports of such ballooning deformity around the nonunion site. Total humerus replacement can be one of the treatment options in cases where nonunion surgery is extremely difficult, depending on the patient's age and activities of daily living.

  Jan. 2022, Journal of orthopaedic case reports, 12(1) (1), 89 - 91, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 前十字靱帯再建術術前の膝伸展筋力と術後1年でのスポーツ復帰およびプレーに対する満足度の関連

  上田 雄也, 松下 雄彦, 柴田 洋平, 瀧口 耕平, 小野 くみ子, 小野 玲, 長井 寛斗, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (一社)日本理学療法学会連合, Dec. 2021, 理学療法学, 48(Suppl.1) (Suppl.1), 4 - 4, Japanese


• 膝前十字靱帯再建術後の膝伸展筋力回復を予測する予測スコアの開発および検証

  上田 雄也, 松下 雄彦, 柴田 洋平, 三浦 大祐, 瀧口 耕平, 小野 くみ子, 木田 晃弘, 小野 玲, 長井 寛斗, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (公社)日本理学療法士協会-近畿ブロック, Dec. 2021, 近畿理学療法学術大会, 61回, S - 2, Japanese


• 前十字靱帯再建術術前の膝伸展筋力と術後1年でのスポーツ復帰およびプレーに対する満足度の関連

  上田 雄也, 松下 雄彦, 柴田 洋平, 瀧口 耕平, 小野 くみ子, 小野 玲, 長井 寛斗, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (一社)日本理学療法学会連合, Dec. 2021, 理学療法学, 48(Suppl.1) (Suppl.1), 4 - 4, Japanese


• 前期高齢者に対する人工膝関節全置換術、術後3年の移動歩行能力の予測

  加藤 達雄, 村津 裕嗣, 井口 貴雄, 西田 亮太, 宮島 明博, 前田 琢磨, 古賀 敬章, 圓尾 明弘, 宮 秀俊, 松本 知之, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2021, 日本人工関節学会誌, 51, 115 - 116, Japanese


• PS-TKAにおける術後1年の移動歩行能力を悪化させる外側弛緩性閾値の検討

  井口 貴雄, 村津 裕嗣, 加藤 達雄, 西田 亮太, 宮島 明博, 前田 琢磨, 古賀 敬章, 圓尾 明弘, 宮 秀俊, 松本 知之, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2021, 日本人工関節学会誌, 51, 215 - 216, Japanese


• PS-TKA術後の膝過伸展を減らすのに有用な術中軟部組織バランスの指標

  西田 亮太, 村津 裕嗣, 井口 貴雄, 加藤 達雄, 宮島 明博, 前田 琢磨, 古賀 敬章, 圓尾 明弘, 宮 秀俊, 松本 知之, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2021, 日本人工関節学会誌, 51, 217 - 218, Japanese


• 後期高齢者に対する人工膝関節全置換術、術後3年の移動歩行能力の予測

  加藤 達雄, 村津 裕嗣, 井口 貴雄, 西田 亮太, 宮島 明博, 前田 琢磨, 古賀 敬章, 圓尾 明弘, 宮 秀俊, 松本 知之, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2021, 日本人工関節学会誌, 51, 229 - 230, Japanese


• 術後早期の膝安定性がPS-TKA術後3年の患者満足度に及ぼす影響

  西田 亮太, 村津 裕嗣, 井口 貴雄, 加藤 達雄, 宮島 明博, 前田 琢磨, 古賀 敬章, 圓尾 明弘, 宮 秀俊, 松本 知之, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2021, 日本人工関節学会誌, 51, 667 - 668, Japanese


• 膝前十字靱帯再建術後の膝伸展筋力回復を予測する予測スコアの開発および検証

  上田 雄也, 松下 雄彦, 柴田 洋平, 三浦 大祐, 瀧口 耕平, 小野 くみ子, 木田 晃弘, 小野 玲, 長井 寛斗, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (公社)日本理学療法士協会-近畿ブロック, Dec. 2021, 近畿理学療法学術大会, 61回, S - 2, Japanese


• Satisfaction with playing pre-injury sports 1 year after anterior cruciate ligament reconstruction using a hamstring autograft

  Yuya Ueda, Takehiko Matsushita, Yohei Shibata, Kohei Takiguchi, Kumiko Ono, Akihiro Kida, Rei Ono, Kanto Nagai, Daisuke Araki, Yuichi Hoshino, Tomoyuki Matsumoto, Takahiro Niikura, Yoshitada Sakai, Ryosuke Kuroda

  Dec. 2021, Knee, 33, 282 - 289

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Treatment of Chronic Osteomyelitis of the Femur by Intramedullary Antibiotic Perfusion (iMAP): A Case Report.

  Keisuke Oe, Akihiro Maruo, Tomoaki Fukui, Hirotsugu Muratsu, Ryosuke Kuroda, Takahiro Niikura

  Introduction: Chronic osteomyelitis is difficult to cure definitively, because local areas are often covered with sequestrum and scar tissues with a poor blood flow; these may render systemic antibiotic administration ineffective. We present a case of chronic osteomyelitis that was successfully treated with continuous local antibiotic perfusion (CLAP) through an intramedullary antibiotic perfusion (iMAP) pin. Case Presentation: A 65-year-old man who suffered an episode of the right femoral osteomyelitis at the age of 15 years experienced a relapse at the age of 63 years. Systemic administration of antibiotics could not control the infection; thus, a surgery was performed. A bone marrow needle (i.e., an iMAP pin; diameter: 3 mm) was percutaneously inserted, from the front, distally and proximally to the cystic lesion in the distal femur. After washing through the iMAP pins, the pins were left indwelling. A closed drain tube was placed on the bone surface, which was close to the fistula of the bone marrow lesion. CLAP therapy was then initiated. Gentamicin was continuously infused through the iMAP pin at a rate of 2 mL/h and drained using the tube. Accordingly, 2.4 mg/mL, 1.2 mg/mL, and 1.2 mg/mL of gentamicin were administered for 4 days using two iMAP pins, for 5-8 days using two iMAP pins, and for 9-15 days using one iMAP pin, respectively, with a syringe pump. The iMAP pins and the drain tube were removed 15 days after the initiation of the CLAP therapy. The C-reactive protein level normalized 25 days postoperatively. The patient recovered full range of motion of the knee joint and recreational sports activity without recurrence of osteomyelitis for 5 years after the therapy. Conclusions: CLAP therapy allows local administration of a sufficient concentration of antibiotics and device removal after treatment is simple. This may be a novel treatment for chronic osteomyelitis.

  Dec. 2021, Journal of orthopaedic case reports, 11(12) (12), 35 - 38, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Direct suturing quadriceps tendon to a continuous loop with a suspensory button provides biomechanically superior fixation in ACL reconstruction.

  Kohei Kamada, Kanto Nagai, Kouki Nagamune, Yuichi Hoshino, Yuta Nakanishi, Daisuke Araki, Noriyuki Kanzaki, Takehiko Matsushita, Ryosuke Kuroda

  PURPOSE: To compare the biomechanical strength of different fixation configurations using suspensory buttons in a soft-tissue quadriceps tendon (QT) grafts in anterior cruciate ligament (ACL) reconstruction. METHODS: Forty bovine QTs, 6-cm long and 10-mm wide, were allocated into four groups with different suture configurations using suspensory buttons (n = 10 in each group): Group A, a baseball suture with a knot tied to the continuous loop with a suspensory button; Group B, same configuration as in Group A but with the knot tied at the opposite end of the baseball suture; Group C, a continuous loop with a suspensory button stitched directly to the QT with simple sutures, and Group D, a baseball suture tied directly to a suspensory button. Biomechanical testing was performed by preloading followed by cyclic loading for 500 cycles between 10 and 100 N. The length of elongation (mm) and maximum load to failure (N) were recorded, and compared among the four groups. RESULTS: Group C showed significantly smaller elongation (4.1 mm [95% CI 3.1-5.2]) than Group A (8.2 mm [95% CI 7.0-9.4]), Group B (10.5 mm [95% CI 7.7-13.3]), and Group D (8.5 mm [95% CI 7.0-9.9]) (A-C; P = 0.004, B-C; P = 0.0001, C-D; P = 0.0018). The maximum load to failure in Group C (386 N [95%CI 306-466]) was significantly higher than that in Group A (196 N [95% CI 141-251]), Group B (226 N [95% CI 164-289]), and Group D (212 N [95%CI 171-253]) (A-C; P = 0.0001, B-C; P = 0.0009, C-D; P = 0.0002). No significant differences were observed between Group A, B, and D in terms of elongation and maximum load to failure. CONCLUSION: The soft-tissue QT graft fixation configuration stitched directly to a continuous loop with suspensory button using simple sutures exhibits small elongation and high maximum load to failure among the four configurations. Regarding clinical relevance, direct suturing of the soft-tissue QT to a continuous loop with a suspensory button may be advantageous for femoral fixation in ACL reconstruction from a biomechanical perspective, and warrant future development of a novel fixation device using this principle.

  Nov. 2021, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Hydration Status of Junior Tennis Players and the Difference after a Lecture on Its Practice.

  Ryo Yoshikawa, Tetsuya Nakatani, Takahiro Furukawa, Noriyuki Kanzaki, Ryosuke Kuroda

  Dehydration reduces exercise performance and causes heat-related illness. However, the fact that dehydration is a serious sports injury is often forgotten, especially among junior tennis players, who engage in tennis matches alone without receiving advice from others. Our objective was to investigate the hydration status of junior tennis players and the difference after attending a lecture on the importance of hydration. In total, 157 junior tennis players attending a training camp participated in this study. The duration of the camp was two days, and a lecture was organized on the first night to educate the players about hydration using a body mass scale. Body mass (BM) was measured immediately before and after practice on the first and second day. The water loss rate (WLR) was calculated by dividing the loss in BM during practice by the BM before practice. In total, 34.4% of players had attended a lecture on hydration in the past. These players had a lower WLR than those who had not, but the difference was not significant. The WLR was significantly lower after attending our lecture than that before. This study suggests that a lecture on hydration could immediately improve the hydration status of the junior tennis players; however, this effect may not be lasting. They may need help from their coaches and parents to implement what they have learned in lecture.

  Nov. 2021, The Kobe journal of medical sciences, 67(3) (3), E79-E83, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Regulatory roles of miRNAs 16, 133a, and 223 on osteoclastic bone destruction caused by breast cancer metastasis.

  Kazumichi Kitayama, Teruya Kawamoto, Yohei Kawakami, Hitomi Hara, Toshiyuki Takemori, Shuichi Fujiwara, Shunsuke Yahiro, Tomohiro Miyamoto, Yutaka Mifune, Yuichi Hoshino, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue

  Osteolytic bone metastasis leads to skeletal‑related events, resulting in a decline in the patient activities and survival; therefore, it is important to understand the mechanism underlying bone metastasis. Recent studies have suggested that microRNAs (miRNAs or miRs) are involved in osteoclast differentiation and/or osteolytic bone metastasis; however, the roles of miRNAs have not been elucidated. In the present study, the roles of miRNAs in bone destruction caused by breast cancer metastasis were investigated in vitro and in vivo. miR‑16, miR‑133a and miR‑223 were transfected into a human breast cancer cell line, MDA‑MB‑231. The expression of osteolytic factors in conditioned medium (miR‑CM) collected from the culture of transfected cells was assessed. To evaluate the effects of miRNAs on osteoclast differentiation and activities, tartrate‑resistant acid phosphatase (TRAP) staining and bone resorptive assays were performed in osteoclasts following miR‑CM treatment. To create in vivo bone metastasis models for histological and morphometric evaluation, miRNA‑transfected MDA‑MB‑231 cells were transplanted into the proximal tibia of nude mice. Expression of osteolytic factors, including receptor activator for nuclear factor‑κB ligand (RANKL), interleukin (IL)‑1β, IL‑6, parathyroid hormone‑related protein (PTHrP), and tumor necrosis factor (TNF), was increased in miR‑16‑CM, whereas it was decreased in both miR‑133a‑CM and miR‑223‑CM. TRAP staining and bone resorptive assays revealed that osteoclast function and activities were promoted by miR‑16‑CM treatment, whereas they were suppressed by miR‑133a‑CM and miR‑223‑CM. Consistent with in vitro findings, in vivo experiments revealed that the overexpression of miR‑16 increased osteoclast activities and bone destruction in MDA‑MB‑231 cells, whereas the opposite results were observed in both miR‑133a‑ and miR‑223‑transfected MDA‑MB‑231 cells. Our results indicated that miR‑16 promoted osteoclast activities and bone destruction caused by breast cancer metastasis in the bone microenvironment, whereas miR‑133a and miR‑223 suppressed them. These miRNAs could be potential biomarkers and therapeutic targets for breast cancer bone metastasis.

  Nov. 2021, International journal of oncology, 59(5) (5), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Clinical Outcomes After Anterior Cruciate Ligament Reconstruction in Patients With a Concomitant Segond Fracture: A Systematic Review

  Kanto Nagai, Kohei Kamada, Jeffrey Kay, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda, Darren de SA

  Background: The Segond fracture can be observed in patients with an anterior cruciate ligament (ACL) tear. It is unclear whether the Segond fracture affects clinical outcomes after ACL reconstruction. Purpose: To investigate whether the presence of a concomitant Segond fracture affects clinical outcomes after ACL reconstruction and to compare clinical outcomes when a Segond fracture is repaired surgically or left unrepaired. Study Design: Systematic review; Level of evidence, 4. Methods: Three databases (PubMed, Embase, Cochrane Library) were searched in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines on July 27, 2020. Relevant studies regarding ACL injury with concomitant Segond fracture treated by primary ACL reconstruction were screened in duplicate. Data regarding patient characteristics and clinical outcomes were extracted. Descriptive data are presented, and a random-effects model was used to pool amenable data. Results: A total of 5 studies examining 2418 patients (987 female; 40.8%), mean age 25.4 years, were included in this study. There were 304 patients with a Segond fracture (mean age, 28.1 years; 35.9% female) and 2114 patients without a Segond fracture (mean age, 25.1 years; 41.5% female). Four studies directly compared outcomes between patients with an unrepaired Segond fracture and no Segond fracture. One study reported 12 patients who underwent ACL reconstruction and repair of a Segond fracture. Among 4 studies, 11 of 292 (3.8%) graft failures/revision surgeries were reported in the groups that had Segond fracture, whereas 145 of 2114 (6.9%) graft failures/revision surgeries were reported in groups that did not have Segond fracture. No significant difference was observed in the risk of graft failure between the 2 groups, with a pooled risk ratio of 0.59 (95% CI, 0.32-1.07; P = .08; I² = 0%). No clinically significant differences were observed with regard to International Knee Document Committee score, Lysholm score, Tegner activity scale, and postoperative knee laxity between the group with Segond fracture and those without. Conclusion: An unrepaired Segond fracture does not appear to have any significant negative effect on postoperative stability or risk of graft failure or revision surgery after ACL reconstruction. Future prospective studies may be warranted to confirm the finding that patients with combined ACL injury and Segond fracture may have outcomes comparable with those of ACL-injured patients without a Segond fracture when isolated ACL reconstruction is performed.

  SAGE Publications, Oct. 2021, The American Journal of Sports Medicine, 51(2) (2), 525 - 533

  Scientific journal


• Combined therapy of platelet-rich plasma and basic fibroblast growth factor using gelatin-hydrogel sheet for rotator cuff healing in rat models.

  Takeshi Kataoka, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Shintaro Mukohara, Takehiko Matsushita, Takahiro Niikura, Yasuhiko Tabata, Ryosuke Kuroda

  INTRODUCTION: Excellent outcomes of arthroscopic rotator cuff repair for small and medium tears have been recently reported. However, re-tears after surgery have been a common complication after surgical repair of large and massive rotator cuff tears and often occur in early postoperative phase. It was previously reported that basic fibroblast growth factor and platelet-rich plasma enhanced rotator cuff tear healing. We hypothesized that this combined therapy could enhance rotator cuff healing after rotator cuff repair in a rat model. This study aimed to evaluate the efficacy of combined therapy of platelet-rich plasma and basic fibroblast growth factor with gelatin-hydrogel sheet. METHODS: To create a rotator cuff defect, the infraspinatus tendon of Sprague Dawley rat was resected from the greater tuberosity. The infraspinatus tendons were repaired and covered with gelatin-hydrogel sheet impregnated with PBS (control group), basic fibroblast growth factor (bFGF group), platelet-rich plasma (PRP group), or both basic fibroblast growth factor and platelet-rich plasma (combined group). Histological examinations were conducted using hematoxylin and eosin, safranin O, and immunofluorescence staining, such as Isolectin B4, type II collagen at 2 weeks postoperatively. For mechanical analysis, ultimate failure load of the tendon-humeral head complex was evaluated at 6 weeks postoperatively. RESULTS: In the hematoxylin and eosin staining, the tendon maturing score of the combined group was higher than that of the control group at postoperative 2 weeks. In the safranin O staining, stronger proteoglycan staining was observed in the combined group compared with the other groups at postoperative 2 weeks. Vascular staining with isolectin B4 in 3 treatment groups was significantly higher than that in the control group. Type II collagen expression in the combined group was significantly higher than those in the other groups. The ultimate failure load of the combined group was significantly higher than that of the control group. CONCLUSION: Combined therapy of basic fibroblast growth factor and platelet-rich plasma promoted angiogenesis, tendon maturing and fibrocartilage regeneration at the enthesis, which could enhance the mechanical strength. It was suggested that combined basic fibroblast growth factor and platelet-rich plasma might enhance both tendon and bone-tendon junction healing, and basic fibroblast growth factor and platelet-rich plasma might be synergistic.

  Oct. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 605 - 605, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 術前の予測因子を組み合わせることで膝前十字靱帯再建術後の膝伸展筋力回復に対する予測能力は向上するか?

  上田 雄也, 松下 雄彦, 柴田 洋平, 瀧口 耕平, 三浦 大祐, 長井 寛斗, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2021, 日本臨床スポーツ医学会誌, 29(4) (4), S174 - S174, Japanese


• 病院職員の健康維持・増進と、業務効率向上の推進を目的とした取り組み

  峯山 佳恵, 上田 雄也, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2021, 日本臨床スポーツ医学会誌, 29(4) (4), S207 - S207, Japanese


• 血管再生医療の現状と課題 CD34陽性細胞移植による血管再生治療

  川本 篤彦, 藤田 靖之, 木下 愼, 古川 裕, 田口 明彦, 坂井 千秋, 坂井 信幸, 新倉 隆宏, 黒田 良祐

  (一社)日本脈管学会, Oct. 2021, 脈管学, 61(Suppl.) (Suppl.), S137 - S137, Japanese


• Preoperative varus deformity of the knee affects the intraoperative joint gap in unicompartmental knee arthroplasty.

  Naoki Nakano, Koji Takayama, Yuichi Kuroda, Toshihisa Maeda, Shingo Hashimoto, Kazunari Ishida, Shinya Hayashi, Yuichi Hoshino, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: It is generally believed that contraction of the soft tissue structures on the medial side may occur in the knee with severe varus deformity. However, the relationship between the severity of varus deformity of the knee and the intraoperative soft tissue balance in unicompartmental knee arthroplasty (UKA) has not been well reported thus far. METHODS: One hundred and three consecutive medial UKAs were enrolled. After the femoral trial prosthesis was placed, the component gap was measured at 10° (extension) and 120° (flexion) of flexion using a UKA tensor. The pre-osteotomy gap was then calculated from the thickness of the bone cut. Paired Student's t-test was used to compare the component gap, as well as the pre-osteotomy gap, in extension and those in flexion. The relationship between the preoperative Hip-Knee-Ankle (HKA) angle and the pre-osteotomy gap was analysed using Pearson's correlation coefficient and simple linear regression analysis. RESULTS: The component gap in extension was significantly smaller than that in flexion while the pre-osteotomy gap in extension was significantly wider than that in flexion. There was a positive correlation between the severity of varus deformation in preoperative knee and the pre-osteotomy gap in extension, while there was no correlation between the preoperative HKA angle and the pre-osteotomy gap in flexion. CONCLUSIONS: The tension of the medial tightness does not correlate with the degree of preoperative varus deformity in UKA.

  Oct. 2021, The Knee, 32, 90 - 96, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Robotic-arm assisted THA can achieve precise cup positioning in developmental dysplasia of the hip : a case control study.

  Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Kazunari Ishida, Nao Shibanuma, Ryosuke Kuroda

  AIMS: This study aimed to evaluate the accuracy of implant placement with robotic-arm assisted total hip arthroplasty (THA) in patients with developmental dysplasia of the hip (DDH). METHODS: The study analyzed a consecutive series of 69 patients who underwent robotic-arm assisted THA between September 2018 and December 2019. Of these, 30 patients had DDH and were classified according to the Crowe type. Acetabular component alignment and 3D positions were measured using pre- and postoperative CT data. The absolute differences of cup alignment and 3D position were compared between DDH and non-DDH patients. Moreover, these differences were analyzed in relation to the severity of DDH. The discrepancy of leg length and combined offset compared with contralateral hip were measured. RESULTS: The mean values of absolute differences (postoperative CT-preoperative plan) were 1.7° (standard deviation (SD) 2.0) (inclination) and 2.5° (SD 2.1°) (anteversion) in DDH patients, and no significant differences were found between non-DDH and DDH patients. The mean absolute differences for 3D cup position were 1.1 mm (SD 1.0) (coronal plane) and 1.2 mm (SD 2.1) (axial plane) in DDH patients, and no significant differences were found between two groups. No significant difference was found either in cup alignment between postoperative CT and navigation record after cup screws or in the severity of DDH. Excellent restoration of leg length and combined offset were achieved in both groups. CONCLUSION: We demonstrated that robotic-assisted THA may achieve precise cup positioning in DDH patients, and may be useful in those with severe DDH. Cite this article: Bone Joint Res 2021;10(10):629-638.

  Oct. 2021, Bone & joint research, 10(10) (10), 629 - 638, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 小中学生野球肘検診における肘離断性骨軟骨炎予測因子の検討

  吉川 智也, 美舩 泰, 乾 淳幸, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2021, 日本臨床スポーツ医学会誌, 29(4) (4), S236 - S236, Japanese


• 深層学習による肘OCDエコー画像の病変検出モデルの作成

  乾 淳幸, 美舩 泰, 吉川 智也, 黒田 良祐, 古川 隆浩

  (一社)日本臨床スポーツ医学会, Oct. 2021, 日本臨床スポーツ医学会誌, 29(4) (4), S237 - S237, Japanese


• Knee osteoarthritis progression is delayed in silent information regulator 2 ortholog 1 knock-in mice

  Tetsuya Yamamoto, Nobuaki Miyaji, Kiminari Kataoka, Kyohei Nishida, Kanto Nagai, Noriyuki Kanzaki, Yuichi Hoshino, Ryosuke Kuroda, Takehiko Matsushita

  Oct. 2021, International Journal of Molecular Sciences, 22(19) (19)

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Attenuation of Knee Osteoarthritis Progression in Mice through Polarization of M2 Macrophages by Intra-Articular Transplantation of Non-Cultured Human Adipose-Derived Regenerative Cells.

  Kohei Kamada, Takehiko Matsushita, Takahiro Yamashita, Tomoyuki Matsumoto, Hideki Iwaguro, Satoshi Sobajima, Ryosuke Kuroda

  Adipose-derived regenerative cells (ADRCs) are non-cultured heterogeneous or mixed populations of cells obtained from adipose tissue by collagenase digestion. The injection of ADRCs have been tried clinically for the treatment of osteoarthritis (OA). The purpose of this study was to evaluate the effect of intra-articular transplantation of human ADRCs on OA progression in mice and the effect of ADRCs on macrophage polarization. In in vivo experiments, BALB/c-nu mice with knee OA received intra-articular transplantation of either phosphate buffered-saline or human ADRCs. OA progression was evaluated histologically and significantly attenuated in the ADRC group at both four and eight weeks postoperatively. The expression of OA-related proteins in the cartilage and macrophage-associated markers in the synovium were examined by immunohistochemistry. The numbers of MMP-13-, ADAMTS-5-, IL-1β-, IL-6- and iNOS-positive cells significantly decreased, and type II collagen- and CD206-positive cells were more frequently detected in the ADRC group compared with that in the control group. In vitro co-culture experiments showed that ADRCs induced macrophage polarization toward M2. The results of this study suggest that the intra-articular transplantation of human ADRCs could attenuate OA progression possibly by reducing catabolic factors in chondrocytes and modulating macrophage polarization.

  Sep. 2021, Journal of clinical medicine, 10(19) (19), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Lateral osteoarthritis progression is associated with a postoperative residual tibiofemoral subluxation in Oxford UKA.

  Tomoyuki Kamenaga, Takafumi Hiranaka, Yuichi Hida, Naoki Nakano, Yuichi Kuroda, Masanori Tsubosaka, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: Lateral compartment osteoarthritis progression (LOP) is a major complication after Oxford mobile-bearing unicompartmental knee arthroplasty (OUKA). This study aimed to identify the association between tibiofemoral subluxation (TFS) and LOP after OUKA. Patients whose TFS was uncorrectable according to preoperative stress radiographs were hypothesised to develop residual TFS even after surgery, and thought to be more likely to develop LOP. METHODS: The study included 201 patients who underwent medial OUKA. Fifteen patients showed increases in LOP of at least two Kellgren-Lawrence grades after surgery [progression (P) group], while the others had no progression (N group, n = 186). TFS was measured on preoperative full leg weight-bearing radiographs, valgus stress radiographs and postoperative plain radiographs. Valgus stress radiographs were obtained using a firm manual valgus force with the knee flexed at 20°. Leg alignment, Oxford knee score (OKS), and revision rates were assessed. RESULTS: The P group had significantly higher TFS values on preoperative valgus stress (6.8° ± 2.2° vs. 4.5° ± 2.0°; P < 0.001) and postoperative radiographs (6.6° ± 2.3° vs. 4.6° ± 2.9°; P < 0.001) than the N group. Patients with postoperative residual TFS and postoperative valgus alignment were more likely to have LOP, but 9 of the 15 LOP patients did not show postoperative valgus alignment. The P group had significantly poorer postoperative OKS (33.0 ± 10.2 vs. 37.4 ± 6.5, P = 0.017) and a higher rate of revision (6/15 vs 6/186; odds ratio = 19.16; 95% CI = 4.98-76.05, P < 0.001). CONCLUSION: OA progression in the lateral compartment after medial OUKA might be associated with postoperative residual TFS, but does not always coexist with postoperative valgus alignment. Preoperative assessment of TFS with valgus stress could be a potential predictor of postoperative residual TFS and LOP. LEVEL OF EVIDENCE: Level III.

  Sep. 2021, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 30(9) (9), 3236 - 3243, English, International magazine

  Scientific journal


• Preoperative uncorrectable tibiofemoral subluxation can worsen clinical outcomes after fixed-bearing unicompartmental knee arthroplasty: a retrospective analysis.

  Tomoyuki Kamenaga, Naoki Nakano, Kazunari Ishida, Masanori Tsubosaka, Yuichi Kuroda, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  INTRODUCTION: The presence of tibiofemoral subluxation (TFS) in patients with unicompartmental arthritis, a potential contraindication to unicompartmental knee arthroplasty (UKA), remains controversial and is not commonly discussed. This study aimed to determine the predictability of postoperative TFS before surgery and the effect of TFS on clinical outcomes after fixed-bearing UKA. MATERIALS AND METHODS: In total, 70 patients with anteromedial osteoarthritis and osteonecrosis of the knee who underwent fixed-bearing UKA from January 2015 to January 2017 were included. The preoperative TFS was assessed using plain anteroposterior and valgus stress radiographs. The patients were classified into three groups as follows: group A (acceptable TFS, n = 36) comprising patients with preoperative TFS less than 5.0 mm; group C (correctable TFS, n = 17) comprising patients with preoperative TFS of more than 5.0 mm but corrected to less than 5.0 mm under valgus stress; and group U (uncorrectable TFS, n = 17) comprising patients with preoperative TFS of more than 5.0 mm under valgus stress. Patient-derived clinical scores were assessed with the 2011 Knee Society Score preoperatively and 2 years postoperatively. The results were compared among the three groups using analysis of variance. RESULTS: Group U showed significantly higher postoperative TFS than groups A and C. Improvements in "symptoms" and "patient satisfaction" scores 2 years after surgery were significantly higher in groups A and C than in group U. CONCLUSION: Preoperative assessment of TFS under valgus stress could be a predictor of postoperative TFS. Furthermore, preoperative uncorrectable TFS could increase pain and decrease patient satisfaction 2 years after undergoing fixed-bearing UKA.

  Sep. 2021, Archives of orthopaedic and trauma surgery, English, International magazine

  Scientific journal


• 慢性再発性多発性骨髄炎の一例

  島 稔樹, 竹森 俊幸, 河本 旭哉, 原 仁美, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2021, 中部日本整形外科災害外科学会雑誌, 64(秋季学会) (秋季学会), 235 - 235, Japanese


• 222nm UVCのヒトに対する安全性と有効性

  新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  (一社)日本環境感染学会, Sep. 2021, 日本環境感染学会総会プログラム・抄録集, 36回, 204 - 204, Japanese


• 糖尿病性骨症の病態と臨床疫学 整形外科から見た糖尿病患者の骨折とそのマネジメント

  新倉 隆宏, 西本 華子, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2021, 日本骨粗鬆症学会雑誌, 7(Suppl.1) (Suppl.1), 165 - 165, Japanese


• 機械学習モデルによる既存椎体骨折の有無の診断の試み

  乾 淳幸, 西本 華子, 美舩 泰, 新倉 隆宏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2021, 日本骨粗鬆症学会雑誌, 7(Suppl.1) (Suppl.1), 268 - 268, Japanese


• コロナ禍における骨粗鬆症患者の骨密度の推移

  西本 華子, 乾 淳幸, 美舩 泰, 丸野 文雅, 金谷 貴子, 新倉 隆宏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2021, 日本骨粗鬆症学会雑誌, 7(Suppl.1) (Suppl.1), 348 - 348, Japanese


• Klippel-Trenaunay症候群の患者に生じた大腿骨感染性偽関節に対する治療経験

  倉科 徹郎, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2021, 中部日本整形外科災害外科学会雑誌, 64(秋季学会) (秋季学会), 215 - 215, Japanese


• Expression profiling of genes in rheumatoid fibroblast-like synoviocytes regulated by Fas ligand via cDNA microarray analysis.

  Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Tomoyuki Matsumoto, Ryosuke Kuroda

  Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation in synovial tissues. Hyperplasia of synovial tissues leads to the formation of pannus that invades the joint cartilage and bone, resulting in joint destruction. Fas ligand (FasL), which is a member of the tumor necrosis factor superfamily, contributes to the pathogenesis of autoimmune diseases, including RA. The current study attempted to identify genes whose expressions in rheumatoid fibroblast-like synoviocytes (RA-FLS) were regulated by FasL, using cDNA microarray. A total of four individual lines of primary cultured RA-FLS were incubated either with recombinant human FasL protein or PBS as an unstimulated control for 12 h. Gene expression was detected using a microarray assay. The results revealed the expression profiles of genes in RA-FLS regulated by Fas and investigated the functions of the genes that were regulated. Among the genes in this profile, the mRNA expression changes of the following genes were indicated to be of note using RT-qPCR: Dual specificity phosphatase 6, epiregulin, interleukin 11, angiopoietin-like 7, protein inhibitor of activated STAT 2 and growth differentiation factor 5. These genes may affect the pathogenesis of RA by affecting apoptosis, proliferation, cytokine production, cytokine-induced inflammation, intracellular signaling, angiogenesis, bone destruction and chondrogenesis. To the best of our knowledge, the current study is the first study to reveal the expression profile of genes in RA-FLS regulated by FasL. The data demonstrated that FasL may regulate the expression of a number of key molecules in RA-FLS, thus affecting RA pathogenesis. Further studies of the genes detected may improve the understanding of RA pathogenesis and provide novel treatment targets for RA.

  Sep. 2021, Experimental and therapeutic medicine, 22(3) (3), 1000 - 1000, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Outcomes of total knee replacement with the use of a NexGen MIS Tibial Component (Mini-keel) : a systematic review.

  Naoki Nakano, Kiyonori Mizuno, Koji Takayama, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  NexGen MIS Tibial Component (Mini-keel) is a tibial component specially developed for minimally invasive surgery in total knee replacement (TKR), and the size limitations of its design and the modular system could affect tibial fixation strength, however, this has not been precisely evaluated thus far. This study aimed to systematically review the literature describing the outcome following TKR with the use of a Mini-keel. Electronic searches of databases were undertaken in July 2019 by two experienced orthopaedic surgeons according to the PRISMA guidelines for literature describing the outcomes of TKR with the use of a Mini-keel. Quality of studies was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. The initial search found a total of 623 studies from all the databases. Seven studies met all the inclusion criteria and were eligible for critical appraisal and quality assessment. In total, 2,198 cases were included in the systematic review. Thirty-five revision cases due to aseptic loosening were found from the systematic review. Two studies were negative about using a Mini-keel and three studies were positive about it, while the other two studies did not judge the quality of a Mini-keel. There have been conflicting conclusions among studies for the use of a Mini-keel. There remains a paucity of prospective cohort studies between TKRs with the use of a Mini-keel and those with the use of a conventional implant, which makes it difficult to determine the usefulness and reliability of this implant.

  Sep. 2021, Acta orthopaedica Belgica, 87(3) (3), 469 - 478, English, International magazine

  Scientific journal


• 機械学習モデルによる既存椎体骨折の有無の診断の試み

  乾 淳幸, 西本 華子, 美舩 泰, 新倉 隆宏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2021, 日本骨粗鬆症学会雑誌, 7(Suppl.1) (Suppl.1), 268 - 268, Japanese


• コロナ禍における骨粗鬆症患者の骨密度の推移

  西本 華子, 乾 淳幸, 美舩 泰, 丸野 文雅, 金谷 貴子, 新倉 隆宏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2021, 日本骨粗鬆症学会雑誌, 7(Suppl.1) (Suppl.1), 348 - 348, Japanese


• 膝関節における再生医療の基礎と臨床 当科における軟骨損傷および変形性膝関節症に対する再生医療の基礎と臨床

  松下 雄彦, 西田 京平, 長井 寛斗, 神崎 至幸, 星野 祐一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2021, 中部日本整形外科災害外科学会雑誌, 64(秋季学会) (秋季学会), 38 - 38, Japanese


• 巨大な骨嚢胞を伴う距骨骨軟骨損傷に対する治療経験

  井上 諒真, 神崎 至幸, 長井 寛斗, 星野 祐一, 松下 雄彦, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2021, 中部日本整形外科災害外科学会雑誌, 64(秋季学会) (秋季学会), 244 - 244, Japanese


• 222nm UVCのヒトに対する安全性と有効性

  新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  (一社)日本環境感染学会, Sep. 2021, 日本環境感染学会総会プログラム・抄録集, 36回, 204 - 204, Japanese


• Hydroxyapatite-coated compaction short stem represents a characteristic pattern of peri-prosthetic bone remodelling after total hip arthroplasty.

  Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Takahiro Niikura, Ryosuke Kuroda

  PURPOSE: We aimed to investigate the differences in peri-prosthetic bone remodelling between the full hydroxyapatite (HA)-collared compaction short stem and the short tapered-wedge stem. METHODS: This retrospective cohort study enrolled 159 consecutive patients (159 joints) undergoing total hip arthroplasty (THA) using the full HA compaction short (n = 64) and short tapered-wedge (n = 95) stems. Body mass index (BMI), peri-prosthetic bone mineral density (BMD), and clinical factors, including the Japanese Orthopaedic Association score and the University of California Los Angeles (UCLA) activity score were assessed and compared. RESULTS: Stem related complications were seen in three cases. Both groups showed similar peri-prosthetic BMD changes. Peri-prosthetic BMD was almost maintained in the distal femur and Gruen zone 6 with both type of stems, but significant BMD loss was found in zones 1 and 7 in both groups and in zone 2 of the full HA compaction stem group. No significant correlations were found between the proximal femoral BMD changes and the age, BMI, and UCLA score in both the full HA compaction and tapered-wedge stem groups. Femoral bone shape affected the peri-prosthetic BMD changes in the tapered-wedge stem group but not in the full HA compaction group. The stem collar of the full HA compaction stem did not affect peri-prosthetic BMD, but unique bone remodelling in the calcar region was observed in 27.6% cases. A significant difference in the peri-prosthetic BMD changes at Gruen zone 2 was found in patients with or without thigh pain. CONCLUSION: Peri-prosthetic bone remodelling remained unaffected by clinical and radiographic factors after THA with the new short full HA compaction stem. Therefore, this new stem may be useful in a variety of cases.

  Aug. 2021, Archives of orthopaedic and trauma surgery, English, International magazine

  Scientific journal


• Analysis of patella movement and posture during knee flexion using a depth camera

  Atsunori Uesaka, Kouki Nagamune, Takehiko Matsushita, Ryosuke Kuroda

  IEEE Computer Society, Aug. 2021, World Automation Congress Proceedings, 2021-, 40 - 43, English

  International conference proceedings


• Ewing肉腫におけるslow-cycling cellsの同定

  八尋 俊輔, 河本 旭哉, 原 仁美, 竹森 俊幸, 藤原 周一, 北山 和道, 宮本 智弘, 青井 貴之, 青井 三千代, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1551 - S1551, Japanese


• 偽関節、感染性偽関節の基礎研究と臨床応用 偽関節患者への自家末梢血CD34陽性細胞移植

  大江 啓介, 新倉 隆宏, 福井 友章, 美舩 泰, 松本 知之, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1464 - S1464, Japanese


• 偽関節、感染性偽関節の基礎研究と臨床応用 Masquelet法の根幹をなすinduced membraneについての組織学的研究

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1465 - S1465, Japanese


• ヒトinduced membraneにおけるbone morphogenetic proteins(BMP)発現の検討

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 高瀬 恭平, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1689 - S1689, Japanese


• Masquelet法induced membrane由来細胞に対するLIPUSによる骨分化誘導

  高瀬 恭平, 新倉 隆宏, 福井 友章, 大江 啓介, 小田 崇弘, 澤内 健一, 吉川 遼, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1697 - S1697, Japanese


• Non-hypertrophic nonunion cellsの増殖能・骨分化能に対するE-BMP-2の効果の検討

  吉川 遼, 新倉 隆宏, 福井 友章, 大江 啓介, 高瀬 恭平, 澤内 健一, 小田 崇弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1814 - S1814, Japanese


• 乳癌骨転移による骨破壊に寄与するmiRNAの検討

  北山 和道, 河本 旭哉, 原 仁美, 川上 洋平, 竹森 俊幸, 藤原 周一, 八尋 俊輔, 宮本 智弘, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1621 - S1621, Japanese


• 電磁気センサーを用いた足関節前方引き出しテストの定量評価の再現性検証

  片岡 君成, 星野 祐一, 長宗 高樹, 抽冬 晃司, 山本 哲也, 山下 貴大, 長井 寛斗, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1566 - S1566, Japanese


• SIRT1ノックインマウスにおいて変形性膝関節症の進行は遅延する

  山本 哲也, 松下 雄彦, 片岡 君成, 長井 寛斗, 荒木 大輔, 神崎 至幸, 星野 祐一, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1634 - S1634, Japanese


• mtor阻害剤のtemsirolimusの軟骨細胞保護効果に関する検討

  森 昭嘉, 松下 雄彦, 長井 寛斗, 荒木 大輔, 神崎 至幸, 星野 祐一, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1728 - S1728, Japanese


• 前十字靱帯損傷膝における腸脛靱帯Kaplan線維損傷のpivot-shift現象への影響

  渡邉 秀, 長井 寛斗, 星野 祐一, 片岡 君成, 中西 雄太, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1790 - S1790, Japanese


• 膝前十字靱帯解剖学的二重束再建術における脛骨骨孔重複の回避する脛骨ガイドの効果および骨孔位置に関する検討

  抽冬 晃司, 星野 祐一, 渡邉 秀, 森 昭嘉, 中西 雄太, 山本 哲也, 長井 寛斗, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1793 - S1793, Japanese


• 膝前十字靱帯再建術における大腿四頭筋腱締結法の生体力学的比較検討

  鎌田 紘平, 長井 寛斗, 長宗 高樹, 星野 祐一, 中西 雄太, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1795 - S1795, Japanese


• Ewing肉腫におけるslow-cycling cellsの同定

  八尋 俊輔, 河本 旭哉, 原 仁美, 竹森 俊幸, 藤原 周一, 北山 和道, 宮本 智弘, 青井 貴之, 青井 三千代, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1551 - S1551, Japanese


• 偽関節、感染性偽関節の基礎研究と臨床応用 偽関節患者への自家末梢血CD34陽性細胞移植

  大江 啓介, 新倉 隆宏, 福井 友章, 美舩 泰, 松本 知之, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1464 - S1464, Japanese


• 偽関節、感染性偽関節の基礎研究と臨床応用 Masquelet法の根幹をなすinduced membraneについての組織学的研究

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1465 - S1465, Japanese


• ヒトinduced membraneにおけるbone morphogenetic proteins(BMP)発現の検討

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 高瀬 恭平, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1689 - S1689, Japanese


• Non-hypertrophic nonunion cellsの増殖能・骨分化能に対するE-BMP-2の効果の検討

  吉川 遼, 新倉 隆宏, 福井 友章, 大江 啓介, 高瀬 恭平, 澤内 健一, 小田 崇弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1814 - S1814, Japanese


• Sequential Changes in Posterior Shoulder Muscle Elasticity After Throwing as Assessed via Ultrasound Shear Wave Elastography.

  Kohei Yamaura, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takeshi Kataoka, Takashi Kurosawa, Shintaro Mukohara, Takahiro Niikura, Takeshi Kokubu, Ryosuke Kuroda

  Background: Improvements in ultrasound diagnostic equipment and techniques can enable muscle stiffness to be measured quantitatively as muscle elasticity using ultrasound shear wave elastography (USWE), where high muscle elasticity values represent muscle stiffness. Purpose: To use USWE to analyze the sequential changes in muscle elasticity in the posterior shoulder before and after pitching. Study Design: Descriptive laboratory study. Methods: The authors evaluated 14 baseball players who had played in high school or college at an intermediate level. The elasticity of the supraspinatus, infraspinatus (ISP), middle trapezius, lower trapezius (LT), rhomboideus, and serratus anterior muscles of the throwing shoulder was measured using USWE at 3 time points: before, immediately after, and 24 hours after a throwing session of 100 pitches. The authors analyzed the sequential changes in the mean elasticity values of the respective muscles at the 3 time points. Results: The mean elasticity values before, immediately after, and 24 hours after throwing were as follows: supraspinatus: 32.9, 53.4, 43.8 kPa; ISP: 22.7, 44.8, 43.7 kPa; middle trapezius: 45.1, 70.3, 59.9 kPa; LT: 32.8, 45.5, 46.5 kPa; rhomboideus: 29.1, 47.5, 38.8 kPa; and serratus anterior: 19.2, 36.9, 26.5 kPa, respectively. The mean elasticity values for all tested muscles were significantly higher immediately after throwing compared with before throwing (P ≤ .0086 for all), and elasticity values in the ISP and LT remained significantly higher 24 hours after throwing compared with before throwing (P ≤ .019 for both). Conclusion: The study results indicated that pitching significantly increased ISP and LT muscle elasticity even after 24 hours.

  Aug. 2021, Orthopaedic journal of sports medicine, 9(8) (8), 23259671211021362 - 23259671211021362, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 糖尿病を伴う肩腱板断裂における肩関節内組織別AGEs(advanced glycation end-products)沈着量とその影響に関する検討

  篠原 一生, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1503 - S1503, Japanese


• 術後の腱板修復に影響を与える因子 ラット腱板修復モデルにおけるティラピア由来うろこコラーゲンの有効性の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 向原 伸太郎, 吉川 智也, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1592 - S1592, Japanese


• AIモデルによる肘関節離断性骨軟骨炎の超音波画像診断

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1644 - S1644, Japanese


• 人工知能モデルによる関節リウマチへの生物学的製剤治療効果の予測

  前田 俊恒, 林 申也, 乾 淳幸, 黒田 雄一, 中野 直樹, 西本 華子, 橋本 慎吾, 美舩 泰, 松本 知之, 松原 司, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1732 - S1732, Japanese


• 糖尿病患者における糖化・酸化ストレスが腱板に及ぼす影響

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1741 - S1741, Japanese


• 糖尿病の有無による腱板断裂患者の関節包へのAGEs(advanced glycation end-products)沈着量の検討

  篠原 一生, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1742 - S1742, Japanese


• 三次元電磁気センサを使用した遠位橈尺関節不安定性の定量化

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 吉川 智也, 篠原 一生, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1744 - S1744, Japanese


• Deep learningを用いたTFCC損傷のエコー画像診断

  篠原 一生, 乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1745 - S1745, Japanese


• 粒子画像流速測定法によるTFCC(triangular fibrocartilage complex)損傷の超音波断層像の評価

  篠原 一生, 乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1746 - S1746, Japanese


• 糖尿病性腱障害に対するquercetin投与効果の検討

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1829 - S1829, Japanese


• Correction to: Utilization of Mechanical Stress to Treat Osteoporosis: The Effects of Electrical Stimulation, Radial Extracorporeal Shock Wave, and Ultrasound on Experimental Osteoporosis in Ovariectomized Rats.

  Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama

  Aug. 2021, Calcified tissue international, 109(2) (2), 230 - 230, English, International magazine


• Knee Flexion Angle Following Total Knee Arthroplasty Relates to a Preoperative Range of Motion of the Hip

  Naoki Nakano, Seiji Kubo, Yutaka Sato, Koji Takayama, Kiyonori Mizuno, Ryosuke Kuroda, Tomoyuki Matsumoto

  Aug. 2021, Indian Journal of Orthopaedics, 55(4) (4), 948 - 952

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A new quantitative evaluation system for distal radioulnar joint instability using a three-dimensional electromagnetic sensor.

  Shintaro Mukohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Tomoya Yoshikawa, Issei Shinohara, Yuichi Hoshino, Kouki Nagamune, Ryosuke Kuroda

  BACKGROUND: The accurate assessment of distal radioulnar joint (DRUJ) instability is still challenging as there is no established objective evaluation method. This study aimed to develop a noninvasive measurement method using a three-dimensional electromagnetic sensor system (EMS) to quantitatively assess and characterize the normal DRUJ movement in healthy volunteers. METHODS: The DRUJ movement was mimicked using both a block model and saw bone. Movement of the models was measured by EMS, and the accuracy and reproducibility of the measurements were assessed. In vivo measurement was performed in a sitting position with the elbow flexed and the forearm pronated. One sensor each was attached to the distal radial shaft and the ulnar head. The examiners fixed the distal radius and the carpal bones, moved the ulnar head from the dorsal to the volar side and measured the dorsovolar translation. The volar translation was measured by EMS and ultrasonography, and the correlation coefficient was calculated. The dorsovolar translation was evaluated in 14 healthy volunteers (7 men and 7 women) by three hand surgeons. The intraclass and inter-rater correlation coefficients (ICCs), the differences between the dominant and non-dominant sides and between men and women were assessed. RESULTS: The accuracy and reproducibility assessment results of the EMS showed high accuracy and reproducibility. In the comparison between EMS and ultrasonography, the correlation coefficient was 0.920 (p = 0.16 × 10-3). The ICC (1,5) for the intra-rater reliability was 0.856, and the ICC (2,5) for inter-rater reliability was 0.868. The mean ulnar head translation and difference between dominant and non-dominant sides were 6.00 ± 1.16 mm (mean ± SD) and - 0.12 ± 0.40 mm, respectively. There were no significant differences between any of the parameters. CONCLUSIONS: A new measurement method using EMS could evaluate DRUJ movement with high accuracy, reproducibility, and intra- and inter-rater reliability. In healthy volunteers, the dorsovolar ulnar head translation was 6.00 mm. The difference between the dominant and non-dominant sides was < 1.0 mm with no significant difference. EMS provided an objective, non-invasive, real-time assessment of dynamic changes in the DRUJ. These findings could be useful in the treatment of patients with DRUJ instability.

  Jul. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 452 - 452, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Surgical outcomes and risk factors for poor outcomes in patients with cervical spine metastasis: a prospective study.

  Yutaro Kanda, Kenichiro Kakutani, Yoshitada Sakai, Zhongying Zhang, Takashi Yurube, Shingo Miyazaki, Yuji Kakiuchi, Yoshiki Takeoka, Ryu Tsujimoto, Kunihiko Miyazaki, Hiroki Ohnishi, Yuichi Hoshino, Toru Takada, Ryosuke Kuroda

  BACKGROUND: Few studies have addressed the impact of palliative surgery for cervical spine metastasis on patients' performance status (PS) and quality of life (QOL). We investigated the surgical outcomes of patients with cervical spine metastasis and the risk factors for a poor outcome with a focus on the PS and QOL. METHODS: We prospectively analyzed patients with cervical spine metastasis who underwent palliative surgery from 2013 to 2018. The Eastern Cooperative Oncology Group PS (ECOGPS) and EuroQol 5-Dimension (EQ5D) score were assessed at study enrollment and 1, 3, and 6 months postoperatively. Neurological function was evaluated with Frankel grading. Univariate and multivariate analyses were performed to identify the risk factors for a poor surgical outcome, defined as no improvement or deterioration after improvement of the ECOGPS or EQ5D score within 3 months. RESULTS: Forty-six patients (mean age, 67.5 ± 11.7 years) were enrolled. Twelve postoperative complications occurred in 11 (23.9%) patients. The median ECOGPS improved from PS3 at study enrolment to PS2 at 1 month and PS1 at 3 and 6 months postoperatively. The mean EQ5D score improved from 0.085 ± 0.487 at study enrolment to 0.658 ± 0.356 at 1 month and 0.753 ± 0.312 at 3 months. A poor outcome was observed in 18 (39.1%) patients. The univariate analysis showed that variables with a P value of < 0.10 were sex (male), the revised Tokuhashi score, the new Katagiri score, the level of the main lesion, and the Frankel grade at baseline. The multivariate analysis identified the level of the main lesion (cervicothoracic junction) as the significant risk factor (odds ratio, 5.00; P = 0.025). CONCLUSIONS: Palliative surgery for cervical spine metastasis improved the PS and QOL, but a cervicothoracic junction lesion could be a risk factor for a poor outcome.

  Jul. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 423 - 423, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• トップアスリートの外傷・障害とその治療

  黒田 良祐, 大江 啓介, 福井 友章, 新倉 隆宏

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S13 - S13, Japanese


• AFFの治療 インプラント周囲に発生した非定型大腿骨骨折について

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S30 - S30, Japanese


• 治療に難渋する骨折 偽関節治療への新たなアプローチ

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S41 - S41, Japanese


• 骨修飾薬使用中の悪性腫瘍骨転移患者に発生した非定型大腿骨骨折の治療経過に関する多施設共同研究

  福井 友章, 新倉 隆宏, 大江 啓介, 高原 俊介, 櫻井 敦志, 岩倉 崇, 正田 悦朗, 吉田 圭二, 伊藤 研二郎, 平中 崇文, 角田 雅也, 黒田 良祐

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S170 - S170, Japanese


• 有限要素法を用いたReamer Irrigator Aspirator施行前後の大腿骨強度評価の検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐, 長宗 高樹

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S198 - S198, Japanese


• 超音波による軟部組織動態の定量化 粒子画像流速測定法による手根管症候群の神経の動態解析

  乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒澤 堯, 黒田 良祐

  日本整形外科超音波学会, Jul. 2021, 日本整形外科超音波学会学術集会プログラム・抄録集, 32回, 74 - 74, Japanese


• ディープラーニングによる手根管症候群の超音波画像診断

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  日本整形外科超音波学会, Jul. 2021, 日本整形外科超音波学会学術集会プログラム・抄録集, 32回, 144 - 144, Japanese


• Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1β-induced inflammation.

  Yoshinori Takashima, Shinya Hayashi, Koji Fukuda, Toshihisa Maeda, Masanori Tsubosaka, Tomoyuki Kamenaga, Kenichi Kikuchi, Masahiro Fujita, Yuichi Kuroda, Shingo Hashimoto, Naoki Nakano, Tomoyuki Matsumoto, Ryosuke Kuroda

  We recently reported that cyclin-dependent kinase inhibitor 1 (p21) deficiency induces osteoarthritis susceptibility. Here, we determined the mechanism underlying the effect of p21 in synovial and cartilage tissues in RA. The knee joints of p21-knockout (p21-/-) (n = 16) and wild type C57BL/6 (p21+/+) mice (n = 16) served as in vivo models of collagen antibody-induced arthritis (CAIA). Arthritis severity was evaluated by immunological and histological analyses. The response of p21 small-interfering RNA (siRNA)-treated human RA FLSs (n = 5 per group) to interleukin (IL)-1β stimulation was determined in vitro. Arthritis scores were higher in p21-/- mice than in p21+/+ mice. More severe synovitis, earlier loss of Safranin-O staining, and cartilage destruction were observed in p21-/- mice compared to p21+/+ mice. p21-/- mice expressed higher levels of IL-1β, TNF-α, F4/80, CD86, p-IKKα/β, and matrix metalloproteinases (MMPs) in cartilage and synovial tissues via IL-1β-induced NF-kB signaling. IL-1β stimulation significantly increased IL-6, IL-8, and MMP expression, and enhanced IKKα/β and IκBα phosphorylation in human FLSs. p21-deficient CAIA mice are susceptible to RA phenotype alterations, including joint cartilage destruction and severe synovitis. Therefore, p21 may have a regulatory role in inflammatory cytokine production including IL-1β, IL-6, and TNF-α.

  Jun. 2021, Scientific reports, 11(1) (1), 12516 - 12516, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• In vitro and in vivo tenocyte-protective effectiveness of dehydroepiandrosterone against high glucose-induced oxidative stress.

  Shintaro Mukohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Tomoya Yoshikawa, Ryosuke Kuroda

  BACKGROUND: Dehydroepiandrosterone (DHEA), an adrenal steroid, has a protective role against diabetes. This study aimed to investigate the in vitro and in vivo protective effects of DHEA against high glucose-induced oxidative stress in tenocytes and tendons. METHODS: Tenocytes from normal Sprague-Dawley rats were cultured in low-glucose (LG) or high-glucose (HG) medium with or without DHEA. The experimental groups were: control group (LG without DHEA), LG with DHEA, HG without DHEA, and HG with DHEA. Reactive oxygen species (ROS) production, apoptosis, and messenger RNA (mRNA) expression of NADPH oxidase (NOX) 1 and 4, and interleukin-6 (IL-6) were determined. Further, diabetic rats were divided into a control group and a DHEA-injected group (DHEA group). NOX1 and NOX4 protein expression and mRNA expression of NOX1, NOX4, IL-6, matrix metalloproteinase (MMP)-2, tissue inhibitors of matrix metalloproteinase (TIMP)-2, and type I and III collagens in the Achilles tendon were determined. RESULTS: In rat tenocytes, DHEA decreased the expression of NOX1 and IL-6, ROS accumulation, and apoptotic cells. In the diabetic rat Achilles tendon, NOX1 protein expression and mRNA expression of NOX1, IL-6, MMP-2, TIMP-2, and type III collagen were significantly lower while type I collagen expression was significantly higher in the DHEA group than in the control group. CONCLUSIONS: DHEA showed antioxidant and anti-inflammatory effects both in vitro and in vivo. Moreover, DHEA improved tendon matrix synthesis and turnover, which are affected by hyperglycemic conditions. DHEA is a potential preventive drug for diabetic tendinopathy.

  Jun. 2021, BMC musculoskeletal disorders, 22(1) (1), 519 - 519, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• がんロコモの現状と課題 脊椎転移に対する集学的治療の効果と限界

  角谷 賢一朗, 張 鐘穎, 由留部 崇, 山本 潤哉, 垣内 裕司, 河本 旭哉, 酒井 良忠, 高田 徹, 黒田 良祐

  (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1240 - S1240, Japanese


• 骨盤悪性骨腫瘍に対する粒子線治療の長期成績

  藤田 郁夫, 竹森 俊幸, 出水 祐介, 今井 礼子, 藤本 卓也, Nor Shazrina, 森下 雅之, 瀧上 俊作, 河本 旭哉, 原 仁美, 藤原 周一, 北山 和道, 八尋 俊輔, 宮本 智弘, 秋末 敏宏, 黒田 良祐, 沖本 智昭

  (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1273 - S1273, Japanese


• 滑膜肉腫に対するL型アミノ酸トランスポータ1(LAT1)の発現およびホウ素中性子捕捉療法(BNCT)適応の検討

  藤本 卓也, 鈴木 実, 倉都 滋之, 藤田 郁夫, 森下 雅之, 須藤 保, 佐久間 淑子, 安藤 徹, 瀧上 俊作, 河本 旭哉, 原 仁美, 竹森 俊幸, 藤原 周一, 北山 和道, 八尋 俊輔, 宮本 智弘, 市川 秀喜, 秋末 敏宏, 黒田 良祐, 廣瀬 隆則

  (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1295 - S1295, Japanese


• Ewing肉腫におけるslow-cycling cellsの同定

  八尋 俊輔, 河本 旭哉, 川上 洋平, 原 仁美, 竹森 俊幸, 藤原 周一, 北山 和道, 宮本 智弘, 青井 貴之, 青井 三千代, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1319 - S1319, Japanese


• 高齢者に発症した骨巨細胞腫についての調査結果

  原 仁美, 河本 旭哉, 竹森 俊幸, 藤原 周一, 北山 和道, 八尋 俊輔, 宮本 智弘, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1343 - S1343, Japanese


• 軟部肉腫における無計画切除例の治療成績と予後因子の検討

  竹森 俊幸, 河本 旭哉, 原 仁美, 藤原 周一, 北山 和道, 八尋 俊輔, 宮本 智弘, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1352 - S1352, Japanese


• 乳癌骨転移における骨破壊に寄与するmiRNAの探索

  北山 和道, 河本 旭哉, 原 仁美, 深瀬 直政, 川上 洋平, 竹森 俊幸, 藤原 周一, 八尋 俊輔, 宮本 智弘, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1364 - S1364, Japanese


• 未分化多形肉腫の治療成績

  河本 旭哉, 森下 雅之, 藤田 郁夫, 原 仁美, 竹森 俊幸, 藤原 周一, 北山 和道, 八尋 俊輔, 宮本 智弘, 藤本 卓也, 瀧上 俊作, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1396 - S1396, Japanese


• 骨盤悪性骨腫瘍に対する粒子線治療の長期成績

  藤田 郁夫, 竹森 俊幸, 出水 祐介, 今井 礼子, 藤本 卓也, Nor Shazrina, 森下 雅之, 瀧上 俊作, 河本 旭哉, 原 仁美, 藤原 周一, 北山 和道, 八尋 俊輔, 宮本 智弘, 秋末 敏宏, 黒田 良祐, 沖本 智昭

  (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1273 - S1273, Japanese


• 滑膜肉腫に対するL型アミノ酸トランスポータ1(LAT1)の発現およびホウ素中性子捕捉療法(BNCT)適応の検討

  藤本 卓也, 鈴木 実, 倉都 滋之, 藤田 郁夫, 森下 雅之, 須藤 保, 佐久間 淑子, 安藤 徹, 瀧上 俊作, 河本 旭哉, 原 仁美, 竹森 俊幸, 藤原 周一, 北山 和道, 八尋 俊輔, 宮本 智弘, 市川 秀喜, 秋末 敏宏, 黒田 良祐, 廣瀬 隆則

  (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1295 - S1295, Japanese


• Ewing肉腫におけるslow-cycling cellsの同定

  八尋 俊輔, 河本 旭哉, 川上 洋平, 原 仁美, 竹森 俊幸, 藤原 周一, 北山 和道, 宮本 智弘, 青井 貴之, 青井 三千代, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1319 - S1319, Japanese


• 高齢者に発症した骨巨細胞腫についての調査結果

  原 仁美, 河本 旭哉, 竹森 俊幸, 藤原 周一, 北山 和道, 八尋 俊輔, 宮本 智弘, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1343 - S1343, Japanese


• 軟部肉腫における無計画切除例の治療成績と予後因子の検討

  竹森 俊幸, 河本 旭哉, 原 仁美, 藤原 周一, 北山 和道, 八尋 俊輔, 宮本 智弘, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1352 - S1352, Japanese


• 乳癌骨転移における骨破壊に寄与するmiRNAの探索

  北山 和道, 河本 旭哉, 原 仁美, 深瀬 直政, 川上 洋平, 竹森 俊幸, 藤原 周一, 八尋 俊輔, 宮本 智弘, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1364 - S1364, Japanese


• 未分化多形肉腫の治療成績

  河本 旭哉, 森下 雅之, 藤田 郁夫, 原 仁美, 竹森 俊幸, 藤原 周一, 北山 和道, 八尋 俊輔, 宮本 智弘, 藤本 卓也, 瀧上 俊作, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1396 - S1396, Japanese


• Ultrasound Frequency-Based Monitoring for Bone Healing.

  Yohei Kumabe, Keisuke Oe, Masakazu Morimoto, Naomi Yagi, Tomoaki Fukui, Ryosuke Kuroda, Yutaka Hata, Takahiro Niikura

  Correct assessment of the bone healing process is required for the management of limb immobilization during the treatment of bone injuries, including fractures and defects. Although the monitoring of bone healing using ultrasound poses several advantages regarding cost and ionizing radiation exposure compared with other dominant imaging methods, such as radiography and computed tomography (CT), traditional ultrasound B-mode imaging lacks reliability and objectivity. However, the body structures can be quantitatively observed by ultrasound frequency-based methods, and therefore, the disadvantages of B-mode imaging can be overcome. In this study, we created a femoral bone hole model of a rat and observed the bone healing process using the quantitative ultrasound method and micro-CT, which provides a reliable assessment of the tissue microstructure of the bone. This study analyzed the correlation between these two assessments. The results revealed that the quantitative ultrasound measurements correlated with the CT measurements for rat bone healing. This ultrasound frequency-based method could have the potential to serve as a novel modality for quantitative monitoring of bone healing with the advantages of being less invasive and easily accessible. Impact statement Bone healing monitoring with ultrasound is advantageous as it is less invasive and easily accessible; however, the traditional B-mode method lacks reliability and objectivity. This study demonstrated that the proposed ultrasound frequency-based monitoring method can quantitatively observe bone healing and strongly correlates with the computed tomography measurements for rat bone healing. This method has the potential to become a reliable modality for monitoring bone healing.

  Jun. 2021, Tissue engineering. Part C, Methods, 27(6) (6), 349 - 356, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• External rotation of the tibial component should be avoided in lateral unicompartmental knee arthroplasty.

  Masahiro Fujita, Takafumi Hiranaka, Brang Mai, Tomoyuki Kamenaga, Masanori Tsubosaka, Koji Takayama, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: Lateral unicompartmental knee arthroplasty (UKA) leads to good clinical outcomes for isolated lateral osteoarthritis. However, the impact of the tibial component position on postoperative outcomes in lateral UKA is yet to be determined. PURPOSE: This study investigated the influence of tibial component malposition on clinical outcomes in lateral UKA. MATERIALS: This was a retrospective study of 50 knees (mean age 73.5 years) who underwent lateral UKA between September 2013 and January 2019. The Oxford Knee Score (OKS), Knee Society Score - Knee (KSSK), and Knee Society Score - Function (KSSF) were evaluated. The coronal alignment, posterior slope of tibial component, tibial component rotation relative to Akagi's line (angle α), and femoral anteroposterior (AP) axis (angle β) were measured postoperatively. The average follow up period was 2.3 (range, 1-4.9) years. RESULTS: Clinical scores were significantly improved after lateral UKA. The mean coronal alignment was 0.9° ± 3.2° varus (range, 9.1° varus to 5.5° valgus), the mean posterior slope was 6.8° ± 3.8° (range, 0.8° to 14.8°). The mean α and β angles, were 4.1° ± 5.8° (range, -9.7° to 16.5°) and 6.7° ± 7.1° (range, -7.0° to 20.5°) external rotation. The angle α had significant negative correlations with postoperative OKS (r = -0.36), KSSK (r = -0.28), and KSSF (r = -0.39), and angle β had significant negative correlations with postoperative OKS (r = -0.34) and KSSK (r = -0.46). CONCLUSION: Excessive external rotation of the tibial component could negatively influence the postoperative outcomes of lateral UKA.

  Jun. 2021, The Knee, 30, 70 - 77, English, International magazine

  Scientific journal


• Comparison of clinical and biomechanical outcomes between the kinematic and mechanical alignment methods in total knee arthroplasty: Protocol for a multicenter randomized controlled trial.

  Yoshinori Takashima, Tomoyuki Matsumoto, Koji Takayama, Naoki Nakano, Yuichi Kuroda, Masanori Tsubosaka, Tomoyuki Kamenaga, Kenichi Kikuchi, Masahiro Fujita, Kemmei Ikuta, Kensuke Anjiki, Shinya Hayashi, Shingo Hashimoto, Toshihisa Maeda, Takao Inokuchi, Mitsunori Toda, Takaaki Chin, Ryosuke Kuroda

  Introduction: The concept of anatomic restoration has garnered considerable interest in the form of kinematically aligned total knee arthroplasty (KA-TKA). KA-TKAs have been reported to reproduce natural alignment and kinematics. However, few randomized controlled trials (RCTs) have compared the biomechanical outcomes and the long-term clinical outcomes of KA-TKA with those of mechanically aligned TKA (MA-TKA). We aim to investigate the long-term clinical and biomechanical effects of KA-TKA and to determine whether KA-TKA or MA-TKA is more appropriate for primary TKA. Methods: This trial will compare clinical and biomechanical outcomes of KA-TKA to those of MA-TKA. Two hundred patients will be enrolled in the RCT and randomized into KA-TKA or MA-TKA groups. Both the groups will be evaluated 1 week before the operation, on the day of the operation, 6 months after the operation, and 1, 5, and 10 years after the operation. The primary outcome is the difference between preoperative and 1-year postoperative functional activity scores of the 2011 Knee Society Score (2011 KSS) in both groups as well as the differences between the scores of both groups. The secondary outcomes will include differences in symptom, satisfaction, and expectation scores of the 2011 KSS, intraoperative kinematics evaluation, postoperative clinical outcomes and complications, pre- and postoperative gait analyses and radiograph evaluations between both KA-TKA and MA-TKA.

  Jun. 2021, Contemporary clinical trials communications, 22, 100775 - 100775, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Involvement of Autophagy in Rat Tail Static Compression-Induced Intervertebral Disc Degeneration and Notochordal Cell Disappearance.

  Takashi Yurube, Hiroaki Hirata, Masaaki Ito, Yoshiki Terashima, Yuji Kakiuchi, Ryosuke Kuroda, Kenichiro Kakutani

  The intervertebral disc is the largest avascular low-nutrient organ in the body. Thus, resident cells may utilize autophagy, a stress-response survival mechanism, by self-digesting and recycling damaged components. Our objective was to elucidate the involvement of autophagy in rat experimental disc degeneration. In vitro, the comparison between human and rat disc nucleus pulposus (NP) and annulus fibrosus (AF) cells found increased autophagic flux under serum deprivation rather in humans than in rats and in NP cells than in AF cells of rats (n = 6). In vivo, time-course Western blotting showed more distinct basal autophagy in rat tail disc NP tissues than in AF tissues; however, both decreased under sustained static compression (n = 24). Then, immunohistochemistry displayed abundant autophagy-related protein expression in large vacuolated disc NP notochordal cells of sham rats. Under temporary static compression (n = 18), multi-color immunofluorescence further identified rapidly decreased brachyury-positive notochordal cells with robust expression of autophagic microtubule-associated protein 1 light chain 3 (LC3) and transiently increased brachyury-negative non-notochordal cells with weaker LC3 expression. Notably, terminal deoxynucleotidyl transferase dUTP nick end labeling-positive apoptotic death was predominant in brachyury-negative non-notochordal cells. Based on the observed notochordal cell autophagy impairment and non-notochordal cell apoptosis induction under unphysiological mechanical loading, further investigation is warranted to clarify possible autophagy-induced protection against notochordal cell disappearance, the earliest sign of disc degeneration, through limiting apoptosis.

  May 2021, International journal of molecular sciences, 22(11) (11), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Knee Stability following Posterior-Stabilized Total Knee Arthroplasty: Comparison of Medial Preserving Gap Technique and Measured Resection Technique

  Masanori Tsubosaka, Hirotsugu Muratsu, Naoki Nakano, Tomoyuki Kamenaga, Yuichi Kuroda, Takao Inokuchi, Hidetoshi Miya, Ryosuke Kuroda, Tomoyuki Matsumoto

  Abstract Novel medial preserving gap technique (MPGT) focuses on medial compartment stability and allows lateral physiological laxity. This study aimed to compare the MPGT with the measured resection technique (MRT) to determine which provides better postoperative knee stability after posterior-stabilized total knee arthroplasty (PS-TKA). Primary PS-TKA, using either MPGT (n = 65) or MRT (n = 65), was performed in 130 patients with varus knee osteoarthritis. Postoperative knee stabilities at extension and flexion were assessed using varus–valgus stress radiographs and stress epicondylar view, respectively (at 1 month, 6 months, 1 year, and 3 years postoperatively). The distance between the femoral prosthesis and polyethylene insert was measured on each medial and lateral side, defined as the medial joint opening (MJO) and lateral joint opening (LJO), respectively. Decreasing MJO or LJO translated to increasing postoperative stability. The femoral external rotation angle was compared between the two surgical techniques; postoperative knee stability was also compared between the medial and lateral compartments, as well as the surgical techniques. A significant difference was found in the femoral external rotation angle between MPGT (4.2 ± 0.2 degrees) and MRT (3.6 ± 0.1 degrees, p < 0.01). Postoperative MJOs both at extension and flexion were significantly smaller than LJOs using MPGT and MRT at all time points (p < 0.05). MJOs and LJOs at extension using MPGT were significantly smaller than those when using MRT, at 1 and 3 years postoperatively (p < 0.05). Furthermore, MJOs at flexion using MPGT were significantly smaller than those when using MRT at 6 months, 1 year, and 3 years postoperatively (p < 0.05). MPGT provided higher postoperative medial knee stability than MRT both at extension and flexion, even at 3 years after PS-TKA. This suggests that this newly developed surgical technique is a more feasible option than MRT for the preservation of postoperative medial knee stability.

  Georg Thieme Verlag KG, May 2021, The Journal of Knee Surgery, 36(01) (01), 095 - 104, English, International magazine

  Scientific journal


• Comparison of plantar pressure distribution during walking and lower limb alignment between modified kinematically and mechanically aligned total knee arthroplasty.

  Tomoyuki Kamenaga, Naoki Nakano, Koji Takayama, Masanori Tsubosaka, Yoshinori Takashima, Kenichi Kikuchi, Masahiro Fujita, Yuichi Kuroda, Shingo Hashimoto, Shinya Hayashi, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Lower extremity alignment is very important after total knee arthroplasty (TKA). This study aimed to compare the plantar pressure distribution while walking and the overall limb alignment, including the hindfoot, between kinematically (KA) and mechanically aligned (MA) TKA. The plantar pressure distribution was investigated using a pressure plate during walking and one-leg standing among four groups: patients one year after KA-TKA (KA group; n = 25), patients one year after MA-TKA (MA group, n = 25), patients with osteoarthritis (OA) undergoing non-surgical care (OA group, n = 25), and healthy controls (Healthy group; n = 25). Conventional and true mechanical axes (the line from the femoral head to the lowest point of the calcaneus) were evaluated on unipedal standing long-leg radiographs in the KA, MA, and OA groups. Results were compared using analysis of variance. The OA group showed a lateral loading pattern in the mid- and rearfoot, while the MA group showed a medial rearfoot loading pattern during walking. On the contrary, the KA and Healthy groups showed an almost equal pressure distribution between the medial and lateral rearfoot. Moreover, although both mechanical axes in the KA group passed through the knee more medially, a more neutral alignment was achieved in the true mechanical axis compared to that in the MA group. KA-TKA results in more neutral weight-bearing through the true mechanical axis and allows patients to walk while maintaining medial and lateral rearfoot pressure more evenly than MA-TKA.

  May 2021, Journal of biomechanics, 120, 110379 - 110379, English, International magazine

  Scientific journal


• Femoro-Epiphyseal Acetabular Roof (FEAR) Index and Anterior Acetabular Coverage Correlate With Labral Length in Developmental Dysplasia of the Hip.

  Yuichi Kuroda, Shingo Hashimoto, Masayoshi Saito, Tomoyuki Matsumoto, Naoki Nakano, Ryosuke Kuroda, Shinya Hayashi

  PURPOSE: The aim of this study was to evaluate the association between labral length and radiographic parameters of lateral and anterior acetabular coverage and the femoro-epiphyseal acetabular roof (FEAR) index in patients with developmental dysplasia of the hip (DDH). METHODS: We retrospectively analyzed data from patients with DDH who visited our hip joint clinic for the first time due to hip symptoms. DDH presence was defined as a lateral center-edge angle (LCEA) of ≤25°. The labral lengths on the anterior and lateral sides were measured on central axial and central coronal slices of T1-weighted magnetic resonance imaging, respectively. The Pearson correlation coefficients (r) and simple linear regression analyses were performed to determine the association of the lateral and anterior labral lengths with the radiographic parameters, including the LCEA, acetabular roof obliquity, FEAR index, anterior wall index, and vertical center anterior angle. RESULTS: This study included 88 patients, with a mean age of 39.6 ± 11.8 years. There were 65 women and 23 men. The lateral and anterior labral lengths correlated with all parameters of dysplasia. Specifically, the lateral labral length had a strong positive correlation with the FEAR index (R = 0.65, P < .001). The anterior labral length had a strong negative correlation with the anterior wall index (R = -0.66, P < .001). CONCLUSIONS: The lateral labral length had a strong positive correlation with the FEAR index. Furthermore, the anterior labral length had a correlation with the anterior dysplasia. LEVEL OF EVIDENCE: Level III, retrospective cross-sectional study.

  May 2021, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, English, International magazine

  Scientific journal


• A postoperative displacement measurement method for femoral neck fracture internal fixation implants based on femoral segmentation and multi-resolution frame registration

  Kaifeng Liu, Kouki Nagamune, Keisuke Oe, Ryosuke Kuroda, Takahiro Niikura

  MDPI AG, May 2021, Symmetry, 13(5) (5), English

  Scientific journal


• Effects of trochlear fragmentation on functional outcome in coronal shear fractures: a retrospective comparative study.

  Shintaro Mukohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Tomoya Yoshikawa, Takahiro Waki, Tsukasa Kuroda, Takahiro Niikura, Ryosuke Kuroda

  Background: Coronal shear fractures of the distal humerus are rare injuries, and fragmentation of the capitellum and trochlea with posterior comminution is challenging for surgeons. We retrospectively evaluated the functional outcomes of patients with coronal shear fractures managed with open reduction and internal fixation, focusing on the number of trochlea fragments in Dubberley type 3B fractures. Materials and methods: The functional outcomes of 25 patients, including 8 patients with type 3B fractures, with a mean age (and standard deviation) of 57 ± 20 years, were evaluated at a mean follow-up duration of 15 ± 9 months. Type 3B fractures were classified into two groups: those with two trochlea fragments or less group (group A) and those with three or more fragments (group B). Patient outcomes were assessed with clinical and radiographic examination, range of motion, and the Mayo Elbow Performance scale (MEPS). Results: Two patients with type 3B in group B experienced nonunion, and two patients with type 3B in group A and 1 patient with type 1B demonstrated avascular necrosis on radiographs. The average MEPS score was 96.3 points (range, 70-100), with 18 excellent, 5 good, and 1 fair results. The average range of motion was 10 ± 8 to 130 ± 12. The MEPS score worsened as Dubberley classification progressed from type 1 to type 3 (98.3 vs. 96.7 vs. 88, P = .014, respectively) and subtypes A to B (97.9 vs. 90, P = .014, respectively). In comparing groups A and B, the MEPS score was significantly worse in group B (93.8 vs. 76.3, P = .006). Conclusion: Our open reduction and internal fixation results were largely good, although functional outcomes were diminished as Dubberley classification progressed from type 1 to type 3 and subtype A to B. Type 3B fractures with three trochlea fragments or more in the elderly were the most difficult to treat with open reduction and internal fixation and possibly 1-term total elbow arthroplasty.

  May 2021, JSES international, 5(3) (3), 571 - 577, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 高齢女性におけるQOL評価別身体能力

  西本 華子, 乾 淳幸, 美舩 泰, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2021, The Japanese Journal of Rehabilitation Medicine, 58(特別号) (特別号), 1 - 7, Japanese


• 腱板断裂を伴う関節拘縮に対する全身麻酔下徒手的受動術の成否に関する因子の検討

  美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2021, The Japanese Journal of Rehabilitation Medicine, 58(特別号) (特別号), 3 - 3, Japanese


• Migration Measurement of Pins in Postoperative Recovery of the Proximal Femur Fractures Based on 3D Point Cloud Matching.

  Kaifeng Liu, Kouki Nagamune, Keisuke Oe, Ryosuke Kuroda, Takahiro Niikura

  Background and objectives: Internal fixation is one of the most effective methods for the treatment of proximal femur fractures. The migration of implants after the operation can seriously affect the reduction of treatment and even cause complications. Traditional diagnosis methods can not directly measure the extent of displacement. Methods: Based on the analysis of Hansson pins, this paper proposes a measurement method based on three-dimensional matching, which uses computerized tomography (CT) images of different periods of patients after the operation to analyze the implants' migration in three-dimensional space with the characteristics of fast speed and intuitive results. Results and conclusions: The measurement results show that the method proposed in this paper has more minor errors, more flexible coordinate system conversion, and more explicit displacement analysis than the traditional method of manually finding references in CT images and measuring displacement.

  Apr. 2021, Medicina (Kaunas, Lithuania), 57(5) (5), English, International magazine

  Scientific journal


• Evaluation of consistency of patient-satisfaction score in the 2011 Knee Society Score to other patient-reported outcome measures.

  Shotaro Tachibana, Hirotsugu Muratsu, Masanori Tsubosaka, Akihiro Maruo, Hidetoshi Miya, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: Patient-reported outcome measures (PROMs) are important aspects of evaluating clinical outcomes after total knee arthroplasty (TKA). The patient-satisfaction score in the 2011 Knee Society Score (KSS) is one of the most frequently used questionnaires; however, patient satisfaction is a subjective assessment and is affected by multiple factors. Therefore, we evaluated correlations between the patient-satisfaction score in the 2011 KSS and that of other categories of the 2011 KSS as well as other PROMs. Furthermore, the ceiling effects of each PROMS were also investigated. METHODS: We enrolled 85 patients aged ≥65 years who underwent cruciate retaining TKA. Patients completed various questionnaires, including the 2011 KSS, Forgotten Joint Score-12 (FJS-12), EuroQol 5 Dimension (EQ-5D), and Geriatric Locomotive Function Scale (GLFS-25), one year after TKA. Simple linear regression analysis was used to evaluate correlations between each PROM and the patient-satisfaction score in the 2011 KSS. Ceiling effects of the patient-satisfaction score in the 2011 KSS, FJS-12, EQ-5D and GLFS-25 were evaluated by comparing the number of patients categorized into the top 10% with each PROM. RESULTS: All scores were significantly correlated (p < 0.001) with the patient-satisfaction score in the 2011 KSS (symptoms: r = 0.69, functional activities: r = 0.69, patient expectations: r = 0.73, FJS-12: r = 0.72, EQ-5D: r = 0.67, GLFS-25: r = -0.74). The patient-satisfaction score in the 2011 KSS and GLFS-25 showed a ceiling effect. On the other hand, this effect was not observed in the results of the FJS-12 and EQ-5D. CONCLUSIONS: The patient-satisfaction score in the 2011 KSS correlated with other PROMs, and the indicated level of satisfaction was consistent. The results of the FJS-12 and EQ-5D had good positive correlation to patient satisfaction without ceiling effect.

  Apr. 2021, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, English, Domestic magazine

  Scientific journal


• Histological analysis of induced membranes in patients whose bone defects were treated with the Masquelet technique to identify factors affecting the vascularity of induced membranes.

  Takahiro Niikura, Naoe Jimbo, Masato Komatsu, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Yoshitada Sakai, Tomoo Itoh, Ryosuke Kuroda

  BACKGROUND: Rich vascularity of the induced membrane (IM) is important for Masquelet reconstruction surgery. The factors affecting IM vascularity are not completely understood. This study aimed to investigate these factors using histological samples of human IMs. METHODS: We retrospectively evaluated 36 patients whose bone defects were treated using the Masquelet technique. Two clinical pathologists analyzed histological sections of IM pieces (1 cm2). The number of blood vessels per 1 mm2 was counted and compared among men and women, femur or tibia, with and without free flap surgery, antibiotic impregnation to the cement, osteogenesis inside the membrane, smoking, and diabetes mellitus. The number of blood vessels within the same patient was compared among different time points. Correlation analysis was performed among blood vessel numbers and patient age, duration of cement spacer placement, and histological grading scales (inflammation, foreign body reaction, and fibrosis). RESULTS: IM formation with rich vascularity and some inflammation, foreign body reaction, and fibrosis were histologically confirmed in all patients. We found 37.4 ± 19.1 blood vessels per 1 mm2. The number of blood vessels was significantly lower in patients with than in those without free flap surgery; it was higher in patients with osteogenesis inside the IM. No significant correlations were found in any of the analyses. CONCLUSION: Sex, patient age, smoking, diabetes mellitus, femur or tibia, duration of cement spacer placement, and antibiotic impregnation to the cement did not affect IM vascularization. IM vascularization was reduced in patients with than in those without free flap surgery.

  Apr. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 248 - 248, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Inhibition of Autophagy at Different Stages by ATG5 Knockdown and Chloroquine Supplementation Enhances Consistent Human Disc Cellular Apoptosis and Senescence Induction rather than Extracellular Matrix Catabolism.

  Masaaki Ito, Takashi Yurube, Yutaro Kanda, Yuji Kakiuchi, Yoshiki Takeoka, Toru Takada, Ryosuke Kuroda, Kenichiro Kakutani

  The intervertebral disc is the largest avascular organ. Autophagy is an important cell survival mechanism by self-digestion and recycling damaged components under stress, primarily nutrient deprivation. Resident cells would utilize autophagy to cope with the harsh disc environment. Our objective was to elucidate the roles of human disc cellular autophagy. In human disc cells, serum deprivation and pro-inflammatory interleukin-1β (IL-1β) stimulation increased autophagy marker microtubule-associated protein 1 light chain 3 (LC3)-II and decreased autophagy substrate p62/sequestosome 1 (p62/SQSTM1), indicating enhanced autophagy. Then, RNA interference (RNAi) of autophagy-related gene 5 (ATG5), essential for autophagy, showed decreases in ATG5 protein (26.8%-27.4%, p < 0.0001), which suppressed early-stage autophagy with decreased LC3-II and increased p62/SQSTM1. Cell viability was maintained by ATG5 RNAi in serum-supplemented media (95.5%, p = 0.28) but reduced in serum-free media (80.4%, p = 0.0013) with IL-1β (69.9%, p = 0.0008). Moreover, ATG5 RNAi accelerated IL-1β-induced changes in apoptosis and senescence. Meanwhile, ATG5 RNAi unaffected IL-1β-induced catabolic matrix metalloproteinase release, down-regulated anabolic gene expression, and mitogen-activated protein kinase pathway activation. Lysosomotropic chloroquine supplementation presented late-stage autophagy inhibition with apoptosis and senescence induction, while catabolic enzyme production was modest. Disc-tissue analysis detected age-related changes in ATG5, LC3-II, and p62/SQSTM1. In summary, autophagy protects against human disc cellular apoptosis and senescence rather than extracellular matrix catabolism.

  Apr. 2021, International journal of molecular sciences, 22(8) (8), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Short distance from the keel to the posterior tibial cortex is associated with fracture after cementless Oxford UKA in Asian patients.

  Tomoyuki Kamenaga, Takafumi Hiranaka, Naoki Nakano, Shinya Hayashi, Takaaki Fujishiro, Koji Okamoto, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: Tibial plateau fractures are serious complications of Oxford mobile-bearing unicompartmental knee arthroplasty (OUKA). This study examined where the fracture lines arises and evaluated the keel-cortex distances (KCDs) using three-dimensional computed tomography (3D-CT) and the effects of technical error (assessed by tibial component positions) and proximal tibial morphology on the KCDs. METHODS: This retrospective study included 217 OUKAs with cementless tibial components. Fifteen patients had tibial fractures after surgery. Anterior and posterior KCDs and fracture line origins were assessed using 3D-CT postoperatively. Proximal tibial morphology was assessed using the medial eminence line (MEL), which runs parallel to the tibial axis and passes through the tip of the medial intercondylar eminence of the tibia on long-leg anteroposterior radiograph. Knees had overhanging medial tibial condyle if the MEL passed medially to the medial tibial cortex. KCDs were compared between patients with/without fractures. Tibial component positions were evaluated, considering effects of tibial morphologies and component positions on fracture prevalence and KCDs. RESULTS: Fracture lines were found between the keel and posterior cortex in 12/15 patients. Posterior KCDs were significantly shorter in patients with fractures than in patients without (2.7 ± 1.6 mm vs 5.2 ± 1.7 mm, P < 0.001). Patients with medial overhanging condyles were more likely to have fracture (10/51 vs 5/166, P < 0.001) and had significantly shorter posterior KCD than those without (3.6 ± 1.5 mm vs 5.5 ± 1.8 mm, P < 0.001). Patients with tibial component that was set too medial, low, and valgus had higher rates of fracture than those without (7/39 vs 8/178, P = 0.008). Medial (r = 0.30, P < 0.001), low (r = -0.33, P < 0.001), and valgus implantations (r = 0.35, P < 0.001) of tibial components were related to shorter posterior KCDs. CONCLUSION: Short posterior KCD after OUKA is a risk factor for postoperative tibial fracture. Patients with either malposition of the tibial component (too medial, low, and valgus) and/or a medial overhanging condyle exhibit a shorter distance of posterior KCD and higher rate of fracture. LEVEL OF EVIDENCE: Level III.

  Apr. 2021, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 30(4) (4), 1220 - 1230, English, International magazine

  Scientific journal


• Accuracy of cup position following robot-assisted total hip arthroplasty may be associated with surgical approach and pelvic tilt.

  Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Kazunari Ishida, Nao Shibanuma, Tomoyuki Kamenaga, Ryosuke Kuroda

  This study aimed to investigate the accuracy of cup placement and determine the predictive risk factors for inaccurate cup positioning in robot-assisted total hip arthroplasty (THA). We retrospectively analyzed 115 patients who underwent robot-assisted THA between August 2018 and November 2019. Acetabular cup alignment and three-dimensional (3D) position were measured using pre- or postoperative computed tomography (CT) data. Absolute differences in cup inclination, anteversion, and 3D position were assessed, and their relation to preoperative factors was evaluated. The average measurement of the absolute differences was 1.8° ± 2.0° (inclination) and 1.9° ± 2.3° (anteversion). The average absolute difference in the 3D cup position was 1.1 ± 1.2 mm (coronal plane) and 0.9 ± 1.0 mm (axial plane). Multivariate analysis revealed that a posterior pelvic tilt [odds ratio (OR, 1.1; 95% confidence interval (CI), 1.00-1.23] and anterior surgical approach (OR, 5.1; 95% CI, 1.69-15.38) were predictive factors for inaccurate cup positioning with robot-assisted THA. This is the first study to demonstrate the predictive risk factors (posterior pelvic tilt and anterior surgical approach) for inaccurate cup position in robot-assisted THA.

  Apr. 2021, Scientific reports, 11(1) (1), 7578 - 7578, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Bilateral Tibial Proximal Fractures Caused by Secondary Osteomalacia due to Autoimmune Polyendocrine Syndrome Type 2: A Case Report.

  Daisuke Nakagawa, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Takahiro Niikura

  Introduction: Hypophosphatemic osteomalacia can be overlooked or confused with other musculoskeletal disorders due to the variety of associated clinical, laboratory, and radiographic findings. If osteomalacia is diagnosed early and the fractures are not displaced, they often heal with nutritional supplements, but, if they progress to displaced fractures, they may require surgical intervention. Case Report: We present a case of secondary osteomalacia due to autoimmune polyendocrine syndrome Type 2 due to this condition, the patient developed bilateral tibial proximal fractures and her varus deformity had progressed. No clear indication of the timing for surgery for adults with osteomalacia has been reported. However, medical treatment improves the symptoms of osteomalacia and it is reported that in children, appropriate level of the serum phosphate (P) should be attained and maintained for the successful bone healing after osteotomy. Therefore, we prioritized pharmacological treatment and prescribed surgery after confirming that the value of serum phosphate P had been improved to recommended levels (2.5-3.5 mg/dl). We performed high tibial osteotomy for the right side and gradual correction by an external fixation for the left tibia, because of more severe deformation, and converted to an internal fixation to shorten the treatment period. During conversion, we performed the operation with a locking plate by the minimal invasive plate osteosynthesis method (MIPO). Conclusion: We conclude that the use of different deformity correction methods, depending on the degree of deformity, and the pharmacological treatment of osteomalacia may lead to favorable results.

  Apr. 2021, Journal of orthopaedic case reports, 11(4) (4), 14 - 17, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 深層学習の手法による肘管症候群のエコー画像診断

  乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 篠原 一生, 黒田 良祐

  (一社)日本手外科学会, Apr. 2021, 日本手外科学会雑誌, 38(1) (1), PD6 - 5, Japanese


• 三次元電磁気センサを使用した遠位橈尺関節不安定性の定量化

  向原 伸太郎, 乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 吉川 智也, 篠原 一生, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2021, 日本手外科学会雑誌, 38(1) (1), O2 - 03, Japanese


• 超音波断層像を用いた三角繊維軟骨複合体の動態解析

  篠原 一生, 乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本手外科学会, Apr. 2021, 日本手外科学会雑誌, 38(1) (1), O2 - 10, Japanese


• 腱細胞における高血糖誘導酸化ストレスに対するQuercetin投与効果の検討

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 黒田 良祐

  (一社)日本手外科学会, Apr. 2021, 日本手外科学会雑誌, 38(1) (1), O3 - 01, Japanese


• ディープラーニングによるエコー画像での正中神経の位置検出

  乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 篠原 一生, 黒田 良祐

  (一社)日本手外科学会, Apr. 2021, 日本手外科学会雑誌, 38(1) (1), O46 - 07, Japanese


• Surgical outcomes of metastatic bone tumors in the extremities (Surgical outcomes of bone metastases).

  Hitomi Hara, Yoshitada Sakai, Teruya Kawamoto, Naomasa Fukase, Yohei Kawakami, Toshiyuki Takemori, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Kenichiro Kakutani, Takahiro Niikura, Daisuke Miyawaki, Takuya Okada, Akihiro Sakashita, Yoshinori Imamura, Ryohei Sasaki, Yoshiyuki Kizawa, Hironobu Minami, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Toshihiro Akisue

  Background: Skeletal related events due to metastatic bone tumors markedly affect the activities of daily living (ADL) and quality of life (QOL) in cancer patients. We focused on multidisciplinary therapy for metastatic bone tumors. This study aimed to evaluate the outcomes of surgical treatment for metastatic bone tumors in the extremities. Methods: We retrospectively reviewed 114 patients who underwent surgical treatment for metastatic bone tumors of the extremities between 2008 and 2019 and 69 patients were reassessed for more than 6 months after surgery. The most common primary tumor was renal, followed by lung, thyroid, and breast cancers. We assessed 69 patients' performance status (PS), Barthel Index (BI) for ADL, EuroQol 5 Dimensions (EQ-5D) for QOL, and numerical rating scale (NRS) for pain and analyzed these postoperative values relative to preoperative values using Friedman's test. The postoperative overall survival and the prognostic factors were evaluated using the Kaplan-Meier method, the log-rank test and Cox proportional hazards analysis. Results: The 1-year overall survival rate was 59%, and the median survival time after surgery was 20 months. Primary tumor, visceral metastasis, and surgical procedure were risk factors correlated with overall survival. PS, BI, EQ-5D, and NRS improved at 3 months after surgery and these improvements were maintained for 6 months after surgery regardless of the surgical procedure. Conclusions: The significant factors affecting survival after surgical treatment for bone metastases included the primary tumor, presence of visceral metastases, and internal fixation without tumor resection or curettage. Surgical treatment for metastatic bone tumors effectively reduced pain and improved PS, ADL, and QOL postoperatively after 3 months.

  Apr. 2021, Journal of bone oncology, 27, 100352 - 100352, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Early postoperative clinical recovery of robotic arm-assisted vs. image-based navigated Total hip Arthroplasty.

  Nao Shibanuma, Kazunari Ishida, Tomoyuki Matsumoto, Koji Takayama, Yutaro Sanada, Masahiro Kurosaka, Ryosuke Kuroda, Shinya Hayashi

  BACKGROUND: This study compared the early clinical recovery of total hip arthroplasty (THA) using computer navigation systems (nTHA) and robotic arm-assisted THA (rTHA). METHODS: Thirty prospective subjects who underwent rTHA were clinically compared to 30 subjects who underwent nTHA. Clinical data (surgical time, intraoperative blood loss, pain severity, number of days to independent walking, and Harris Hip Score (HHS) at discharge), and radiographic parameters (inclination and anteversion angles) were statistically compared between the two groups. RESULTS: Follow-up times were 24.3 ± 6.0 and 27.0 ± 7.0 days in the rTHA and nTHA groups, respectively. The surgical time (135.1 ± 13.9 min vs. 146.2 ± 12.8 min, p = 0.002), number of days to independent walking (7.2 ± 2.0 vs. 11.5 ± 3.0 days, p < 0.001), and postoperative pain using a numeric rating scale on postoperative days 7, 10,, and 14 (1.4 ± 0.9 vs. 2.2 ± 1.2, p = 0.005; 1.0 ± 0.8 vs. 1.8 ± 1.1, p = 0.002; 0.3 ± 0.5 vs. 1.1 ± 0.9, p < 0.001; respectively) were significantly reduced in the rTHA group compared to the nTHA group. The rTHA group showed a significantly higher postoperative HHS compared to the nTHA group (85.3 ± .3.2 vs. 81.0 ± 8.5, p = 0.014). No statistically significant difference was observed in radiographic parameters between the groups; however, the incidence of intraoperative target angle changes was significantly lower in the rTHA group than in the nTHA group (0/30 subjects [0%] vs. 11/30 subjects [36.7%], p < 0.001). CONCLUSION: The surgical time, postoperative pain, and number of days to independent walking were significantly shorter, and the HHS at discharge was significantly higher in the rTHA group than in the nTHA group. Thus, compared to the nTHA group, the rTHA group showed improved early clinical recovery.

  Mar. 2021, BMC musculoskeletal disorders, 22(1) (1), 314 - 314, English, International magazine

  Scientific journal


• Modern femoral component design in total knee arthroplasty shows a lower patellar contact force during knee flexion compared with its predecessor.

  Naoki Nakano, Yuichi Kuroda, Toshihisa Maeda, Koji Takayama, Shingo Hashimoto, Kazunari Ishida, Shinya Hayashi, Yuichi Hoshino, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: The relationship between the femoral component design in total knee arthroplasty (TKA) and the patellofemoral contact force, as well as the soft tissue balance, has not been well reported thus far. METHODS: Twenty-eight mobile-bearing posterior-stabilized (PS) TKAs using the traditional model (PFC Sigma) and 27 mobile-bearing PS TKAs using the latest model (Attune) were included. Surgeries were performed using the measured resection technique assisted with the computed tomography (CT)-based free-hand navigation system. After all the trial components were placed, patellar contact forces on the medial and lateral sides were measured using two uniaxial ultrathin force transducers with the knee at 0°, 10°, 30°, 60°, 90°, 120°, and 135° of flexion. The joint component gap and the varus ligament balance of the femorotibial joint were also measured. The non-paired Student's t-test was conducted to compare the values of the two groups. RESULTS: The medial patellar contact force was significantly lower for Attune group than for PFC Sigma group at 120° of knee flexion (P = 0.0058). The lateral patellar contact force was also significantly lower for Attune group than PFC Sigma group at 120° and 135° of knee flexion (P = 0.0068 and P = 0.036). The joint component gap, as well as the varus ligament balance, showed no statistically significant difference between the two groups. CONCLUSIONS: Reduced thickness and width of the anterior flange of the femoral component in the Attune may play a role in low patellar contact force.

  Mar. 2021, The Knee, 30, 1 - 8, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Regeneration Therapy to Treat Fracture Nonunion : Transplantation of Autologous Peripheral Blood CD34-Positive Cells

  黒田 良祐, 新倉 隆宏, 大江 啓介, 福井 友章, 美舩 泰, 松本 知之

  株式会社医学書院, Mar. 2021, 臨床整形外科, 56(3) (3), 241 - 245, Japanese


• Utilization of Mechanical Stress to Treat Osteoporosis: The Effects of Electrical Stimulation, Radial Extracorporeal Shock Wave, and Ultrasound on Experimental Osteoporosis in Ovariectomized Rats.

  Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama

  Current treatment options for osteoporosis primarily involve pharmacotherapies, but they are often accompanied by undesirable side effects. Utilization of mechanical stress which can noninvasively induce bone formation has been suggested as an alternative to conventional treatments. Here, we examined the efficacy of mechanical stress induced by electrical stimulation, radial extracorporeal shock waves, and ultrasound for estrogen-deficient osteoporosis. Female Wistar rats were divided into following five groups: sham-operated group, untreated after ovariectomy, and treated with electrical stimulation, radial extracorporeal shock wave, or ultrasound starting at 8 weeks after ovariectomy for 4 weeks. Trabecular bone architecture of the femur was assessed by micro-CT and its biomechanical properties were obtained by mechanical testing. The femurs were further evaluated by histochemical, immunohistochemical, and real-time PCR analyses. Radial extracorporeal shock wave and ultrasound treatment improved trabecular bone microarchitecture and bone strength in osteoporotic rats, but not electrical stimulation. The shock wave decreased osteoclast activity and RANKL expression. The exposure of ultrasound increased osteoblast activity and β-catenin-positive cells, and they decreased sclerostin-positive osteocytes. These findings suggest that mechanical stress induced by radial extracorporeal shock wave and ultrasound can improve estrogen-deficient bone loss and bone fragility through promoted bone formation or attenuated bone resorption.

  Mar. 2021, Calcified tissue international, 109(2) (2), 215 - 229, English, International magazine

  Scientific journal


• Influence of selected plane on the evaluation of tibial tunnel locations using a three-dimensional bone model in double-bundle anterior cruciate ligament reconstruction.

  Tetsuya Yamamoto, Kanto Nagai, Daisuke Araki, Nobuaki Miyaji, Yuta Nakanishi, Yuichi Hoshino, Noriyuki Kanzaki, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda, Takehiko Matsushita

  BACKGROUND: The purpose of this study was to investigate the influence of a selected plane on the evaluation of tibial tunnel locations following anterior cruciate ligament reconstruction (ACLR) between two planes: the plane parallel to the tibial plateau (Plane A) and the plane perpendicular to the proximal tibial shaft axis (Plane B). METHODS: Thirty-four patients who underwent double-bundle ACLR were included. Three-dimensional model of tibia was created using computed tomography images 2 weeks postoperatively, and tibial tunnels of the anteromedial bundle (AMB) and posterolateral bundle (PLB) were extracted. To evaluate tibial tunnel locations, two planes (Planes A and B) were created. The locations of the tibial tunnel apertures of each bundle were evaluated using a grid method and compared between Planes A and B. The difference in coronal alignment between Planes A and B were also assessed. RESULTS: The AMB and PLB tunnel apertures in Plane A were significantly more laterally located than in Plane B (mean difference; AMB, 1.5%; PLB, 1.7%, P < 0.01). There were no significant differences in the anteroposterior direction between the planes. Coronal alignment difference between the planes was 16.8 ± 2.2°; Plane B was more valgus than Plane A. CONCLUSION: Although tibial tunnel locations were not significantly influenced by the selected planes in the AP direction, subtle but statistically significant differences were found in the ML direction between the Planes A and B in double-bundle anterior cruciate ligament reconstruction. The findings suggest that both Planes A and B can be used in the assessment of tibial tunnel locations after anterior cruciate ligament reconstruction.

  Mar. 2021, The Knee, 29, 298 - 304, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 【骨折に対する積極的保存療法 基礎編】難治性骨折に対する再生医療 自家末梢血CD34陽性細胞移植

  黒田 良祐, 新倉 隆宏, 大江 啓介, 福井 友章, 美舩 泰, 松本 知之

  (株)医学書院, Mar. 2021, 臨床整形外科, 56(3) (3), 241 - 245, Japanese


• 骨端線閉鎖前の習慣性膝蓋骨脱臼に対してproximal realignment法と内側膝蓋大腿靱帯再建術の併用により良好な成績を得た一例

  渡邉 秀, 松下 雄彦, 長井 寛斗, 荒木 大輔, 星野 祐一, 神崎 至幸, 黒田 良祐

  関西関節鏡・膝研究会, Mar. 2021, 関西関節鏡・膝研究会プログラム・演題抄録, 33回, 33 - 33, Japanese


• 膝蓋骨脱臼・不安定症の治療戦略 大腿骨滑車部低形成を伴う症例に対する治療

  松下 雄彦, 荒木 大輔, 長井 寛斗, 神崎 至幸, 星野 祐一, 黒田 良祐

  関西関節鏡・膝研究会, Mar. 2021, 関西関節鏡・膝研究会プログラム・演題抄録, 33回, 41 - 41, Japanese


• 解剖学的二重束前十字靱帯再建術後pivot shift残存のリスク因子の検討

  鎌田 紘平, 松下 雄彦, 長井 寛斗, 荒木 大輔, 神崎 至幸, 星野 祐一, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S199 - S199, Japanese


• 失敗例から学ぶ 膝周囲骨切り術 ピットフォール Distal femoral osteotomyのピットフォール

  松下 雄彦, 荒木 大輔, 長井 寛斗, 森 昭嘉, 片岡 君成, 神崎 至幸, 星野 祐一, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S226 - S226, Japanese


• 半月板損傷の診断と治療

  黒田 良祐, 松下 雄彦, 星野 祐一, 長井 寛斗

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S631 - S631, Japanese


• 整形外科勤務医における内側半月板後根損傷の認知度および治療に関するアンケート調査

  下薗 涼太, 松下 雄彦, 長井 寛斗, 荒木 大輔, 抽冬 晃司, 神崎 至幸, 星野 祐一, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S808 - S808, Japanese


• 若年者における解剖学的二重束前十字靱帯再建術の臨床成績 一重束再建術との比較

  長井 寛斗, 松下 雄彦, 中西 雄太, 荒木 大輔, 星野 祐一, 神崎 至幸, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S842 - S842, Japanese


• 膝前十字靱帯解剖学的二重束再建術における脛骨骨孔重複を予防する新しいガイドの有効性と骨孔位置に関する比較検討

  抽冬 晃司, 星野 祐一, 森 昭嘉, 渡邉 秀, 山本 哲也, 中西 雄太, 山下 貴大, 長井 寛斗, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S845 - S845, Japanese


• ACL損傷膝に合併する半月板損傷が膝関節動揺性評価に与える影響の詳細な検討

  森 昭嘉, 星野 祐一, 鎌田 紘平, 片岡 君成, 抽冬 晃司, 渡邉 秀, 山本 哲也, 長井 寛斗, 荒木 大輔, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S851 - S851, Japanese


• 人工距骨併用人工足関節置換術後の踵骨の骨嚢胞性変化と臨床成績の関係性に関する検討

  抽冬 晃司, 神崎 至幸, 片岡 君成, 山本 哲也, 山下 貴大, 長井 寛斗, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S1095 - S1095, Japanese


• 人工距骨併用による人工足関節再置換術の治療成績

  片岡 君成, 神崎 至幸, 抽冬 晃司, 山本 哲也, 山下 貴大, 長井 寛斗, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S1096 - S1096, Japanese


• 前十字靱帯損傷の治療戦略 正常膝機能を取り戻すために

  黒田 良祐, 松下 雄彦, 星野 祐一, 長井 寛斗

  (一社)中部日本整形外科災害外科学会, Mar. 2021, 中部日本整形外科災害外科学会雑誌, 64(春季学会) (春季学会), 14 - 14, Japanese


• 整形外科勤務医における内側半月板後根損傷の認知度および治療に関するアンケート調査

  下薗 涼太, 松下 雄彦, 長井 寛斗, 荒木 大輔, 星野 祐一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2021, 中部日本整形外科災害外科学会雑誌, 64(春季学会) (春季学会), 122 - 122, Japanese


• 大きな欠損部を伴うアキレス腱再断裂に対してPercutaneous Achilles Repair Systemを用いて治療した1例

  高見 俊治, 神崎 至幸, 長井 寛斗, 荒木 大輔, 星野 祐一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2021, 中部日本整形外科災害外科学会雑誌, 64(春季学会) (春季学会), 135 - 135, Japanese


• 偽関節症例における骨SPECT定量評価についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S152 - S152, Japanese


• Masquelet法におけるinduced membraneのMRI評価についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S153 - S153, Japanese


• 骨修飾薬使用中の悪性腫瘍骨転移患者に発生した非定型大腿骨骨折に関する多施設共同研究

  福井 友章, 新倉 隆宏, 大江 啓介, 森下 雅之, 藤田 郁夫, 高原 俊介, 櫻井 敦志, 岩倉 崇, 吉田 圭二, 伊藤 研二郎, 正田 悦朗, 北田 真平, 平中 崇文, 角田 雅也, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S644 - S644, Japanese


• Isolated Musculocutaneous Nerve Injury in a Professional Baseball Player: A Case Report.

  Takeshi Kataoka, Takeshi Kokubu, Yutaka Mifune, Atsuyuki Inui, Tetsuya Yamazaki, Ryosuke Kuroda

  Introduction: Musculocutaneous nerve lesion in a throwing athlete is a rare condition. We report the case of a professional baseball pitcher with an isolated musculocutaneous nerve lesion that occurred during a pitching motion. Case Presentation: The patient had radiating pain in the upper arm and weakness of elbow flexion. Physical examination revealed flaccid paralysis of the biceps brachii muscle and paresthesia in the right lateral forearm. Musculocutaneous nerve injury was suspected. Because some signs of recovery were observed within a few days, the patient received non-operative management. Nerve conduction studies at 2 weeks after the injury showed low-amplitude compound muscle action potential of the right biceps brachii muscle by stimulation of the musculocutaneous nerve. Needle electromyography showed markedly reduced motor unit potential recruitment in the biceps brachii muscle. He was diagnosed as having isolated musculocutaneous nerve injury. At 2 months after the injury, the muscle contraction and strength of the biceps brachii muscle improved. At 7 months after the injury, muscle weakness was fully recovered. His pitching ability returned to that of a competitive player. Conclusion: Because the neuroparalysis was incomplete and began to recover within a few days, we considered the pathology of this injury to be incomplete axonotmesis, which was successfully treated conservatively.

  Mar. 2021, Journal of orthopaedic case reports, 11(3) (3), 113 - 116, English, International magazine


• ラット腱板修復モデルにおけるティラピア由来うろこコラーゲンの有効性の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 向原 伸太郎, 吉川 智也, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S122 - S122, Japanese


• 機械学習による骨粗鬆症外来受診患者の骨密度予測

  乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 篠原 一生, 楊 鴻生, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S476 - S476, Japanese


• ウェアラブルセンサで測定した投球肘ストレスと超音波剪断波エラストグラフィで評価した前腕回内屈筋群の組織弾性との相関の検討

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S520 - S520, Japanese


• 肩甲部に発生したガングリオンに対して関節鏡視下手術を行った2例

  名倉 一成, 高瀬 史明, 原田 義文, 乾 淳幸, 美舩 泰, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2021, JOSKAS, 46(1) (1), 24 - 25, Japanese


• ディープラーニングによる肘管症候群のエコー画像診断

  乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S865 - S865, Japanese


• 超音波断層像を用いた三角線維軟骨複合体の動態解析

  篠原 一生, 乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S880 - S880, Japanese


• 腱細胞における高血糖誘導酸化ストレスに対するquercetinの抗酸化作用の検討

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S883 - S883, Japanese


• 高血糖誘導酸化ストレスを与えた腱細胞に対するDHEAの効果

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 吉川 智也, 篠原 一生, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S884 - S884, Japanese


• 上腕三頭筋膜による外側側副靱帯再建を行った肘関節後外側回旋不安定症の一例

  中谷 英巴, 美舩 泰, 乾 淳幸, 西本 華子, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2021, 中部日本整形外科災害外科学会雑誌, 64(春季学会) (春季学会), 163 - 163, Japanese


• Double LCP platingによる手関節固定術の治療経験

  若松 亮太, 乾 淳幸, 美舩 泰, 原 仁美, 西本 華子, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2021, 中部日本整形外科災害外科学会雑誌, 64(春季学会) (春季学会), 168 - 168, Japanese


• 軟部肉腫肺転移患者における肺転移の治療アプローチの予後への影響

  河本 旭哉, 原 仁美, 森下 雅之, 藤田 郁夫, 藤本 卓也, 竹森 俊幸, 藤原 周一, 北山 和道, 八尋 俊輔, 宮本 智弘, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S897 - S897, Japanese


• メトトレキサート抵抗例(MTX-IR)に対する2nd抗リウマチ薬(csDMARDs)併用療法としてのイグラチモド・サラゾスルファピリジン(IGU・SASP)併用効果の比較検討 3施設共同臨床試験 A results from the rheumatology multicenter in the university,hospital,and clinic as the retrospective study(ARIES study)

  野崎 祐史, 織部 元廣, 冨田 大介, 伊丹 哲, 李 進海, 舟橋 惠子, 福田 康治, 黒田 良祐, 松原 司, 船内 正憲

  (一社)日本リウマチ学会, Mar. 2021, 日本リウマチ学会総会・学術集会プログラム・抄録集, 65回, 572 - 572, Japanese


• 【骨折に対する積極的保存療法】LIPUSによる骨折の積極的保存療法 超音波骨折治療を有効活用するための照射部位ターゲティング

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (株)医学書院, Mar. 2021, 臨床整形外科, 56(3) (3), 261 - 266, Japanese


• 偽関節症例における骨SPECT定量評価についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S152 - S152, Japanese


• Masquelet法におけるinduced membraneのMRI評価についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S153 - S153, Japanese


• 骨修飾薬使用中の悪性腫瘍骨転移患者に発生した非定型大腿骨骨折に関する多施設共同研究

  福井 友章, 新倉 隆宏, 大江 啓介, 森下 雅之, 藤田 郁夫, 高原 俊介, 櫻井 敦志, 岩倉 崇, 吉田 圭二, 伊藤 研二郎, 正田 悦朗, 北田 真平, 平中 崇文, 角田 雅也, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S644 - S644, Japanese


• PS-TKAにおける術中の外側弛緩性が術後移動歩行能力改善に及ぼす影響

  栖田 慶仁, 村津 裕嗣, 玉岡 拓也, 井口 貴雄, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2021, JOSKAS, 46(1) (1), 126 - 127, Japanese

  Link to Kobe Univ. Repository (Kernel)


• Gap balancing techniqueを用いた人工膝関節置換術における大腿骨後顆骨切り精度の検討

  栖田 慶仁, 村津 裕嗣, 玉岡 拓也, 井口 貴雄, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2021, JOSKAS, 46(1) (1), 136 - 137, Japanese

  Link to Kobe Univ. Repository (Kernel)


• 軟部肉腫肺転移患者における肺転移の治療アプローチの予後への影響

  河本 旭哉, 原 仁美, 森下 雅之, 藤田 郁夫, 藤本 卓也, 竹森 俊幸, 藤原 周一, 北山 和道, 八尋 俊輔, 宮本 智弘, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S897 - S897, Japanese


• A novel topical treatment for bone metastases using a gelatin hydrogel incorporating cisplatin as a sustained release system.

  Yutaro Kanda, Kenichiro Kakutani, Takashi Yurube, Zhongying Zhang, Shingo Miyazaki, Yuji Kakiuchi, Yoshiki Takeoka, Ryu Tsujimoto, Kunihiko Miyazaki, Teruya Kawamoto, Toru Takada, Yuichi Hoshino, Yasuhiko Tabata, Ryosuke Kuroda

  Management of bone metastasis is becoming increasingly important. Thus, local and systemic treatment options have been developed for control. Although systemic administration of anticancer agents is effective for bone metastasis, it is often stopped because of poor general conditions or side effects. Therefore, it is highly desirable to develop a more effective and safer local treatment for bone metastasis. The purpose of the current study was to investigate the antitumor effects and safety of gelatin hydrogel microspheres incorporating cisplatin (GM-CDDP), which we developed as a sustained release system without harmful substances. First, we assessed GM-CDDP for its in vitro degradability and potential for sustained release. Second, in vivo antitumor and side effects were evaluated using a murine bone metastasis model of MDA-MB-231 human breast cancer cells incorporating GFP. In vitro, initial bursts were observed within 2 h and CDDP was released gradually with gelatin hydrogel degradation, which reached 100% at 48 h. In vivo, local administration of GM-CDDP (2 mg/kg) significantly suppressed tumor growth and bone osteolysis compared with the control, and local and systemic administration of free CDDP (2 mg/kg; p < 0.05). Local administration of GM-CDDP significantly reduced loss of body weight and elevation of blood urea nitrogen compared with the systemic administration of free CDDP (p < .05). The current study suggests that local administration of GM-CDDP achieves higher antitumor effects with a potential for lesser side effects compared with local or systemic administration of free CDDP.

  Mar. 2021, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 39(3) (3), 525 - 535, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• BNCT for primary synovial sarcoma.

  Takuya Fujimoto, Minoru Suzuki, Shigeyuki Kuratsu, Ikuo Fujita, Masayuki Morishita, Tamotsu Sudo, Toshiko Sakuma, Yuta Nakamatsu, Yoshinori Sakurai, Takushi Takata, Yuki Tamari, Hiroki Tanaka, Shin-Ichiro Masunaga, Yuko Kinashi, Natsuko Kondo, Shunsuke Sakakibara, Hiroshi Igaki, Tooru Andoh, Setsu Sakamoto, Teruya Kawamoto, Tadashi Watabe, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Tomoyuki Matsumoto, Toshihiro Akisue, Koji Ono, Hideki Ichikawa, Ryosuke Kuroda, Takanori Hirose

  Synovial sarcoma is a rare tumor requiring new treatment methods. A 46-year-old woman with primary monophasic synovial sarcoma in the left thigh involving the sciatic nerve, declining surgery because of potential dysfunction of the affected limbs, received two courses of BNCT. The tumor thus reduced was completely resected with no subsequent recurrence. The patient is now able to walk unassisted, and no local recurrence has been observed, demonstrating the applicability of BNCT as adjuvant therapy for synovial sarcoma. Further study and analysis with more experience accumulation are needed to confirm the real impact of BNCT efficacy for its application to synovial sarcoma.

  Mar. 2021, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 169, 109407 - 109407, English, International magazine

  Scientific journal


• A genome-wide association study identifying the SNPs predictive of rapid joint destruction in patients with rheumatoid arthritis.

  Shinya Hayashi, Tsukasa Matsubara, Koji Fukuda, Toshihisa Maeda, Keiko Funahashi, Marowa Hashimoto, Tomoyuki Kamenaga, Yoshinori Takashima, Ryosuke Kuroda

  Rheumatoid arthritis (RA) is a common chronic autoimmune disease leading to joint destruction. The aim of the present study was to identify the genomic factors predictive of susceptibility to joint destruction in patients with RA by performing a genome-wide association study of genetic variants, including single nucleotide polymorphisms (SNPs). The study sample included 228 patients with a diagnosis of RA in the past 5 years. Patients were classified into rapid (total Sharp score/years of RA, ≥50) and slow (total Sharp score/years of RA, <50) joint destruction groups for analysis. The association between the genome-wide SNP analysis and joint destruction was evaluated. The following SNPs were strongly associated with rapid radiographic joint destruction: rs2295926 (P<1x10-7), belonging to the N-acetylgalactosaminyltransferase 12 (GALNT12) gene and rs11958855 (P<1x10-6), belonging to the KCNN2 gene (associated with the potassium calcium-activated channel subfamily). The identification of genetic predictors of rapid joint destruction in RA (GALNT12 and KCNN2) may provide information regarding potential therapeutic targets, and this information may be used to assist in the management RA disease progression, thereby improving the functional outcomes for patients.

  Mar. 2021, Biomedical reports, 14(3) (3), 31 - 31, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Differences in preoperative planning for high-tibial osteotomy between the standing and supine positions.

  Takehiko Matsushita, Shu Watanabe, Daisuke Araki, Kanto Nagai, Yuichi Hoshino, Noriyuki Kanzaki, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda

  INTRODUCTION: Previous studies have reported that alignment changes depend on the patient's position in orthopedic surgery. However, it has not yet been well examined how the patient's position affects the preoperative planning in high-tibial osteotomy (HTO). Therefore, the aim of this study was to investigate the effects of the patient's position on preoperative planning in HTO. MATERIALS AND METHODS: A total of 60 knees in 55 patients who underwent HTO were retrospectively examined. Virtual preoperative planning for medial open-wedge HTO (OWHTO), lateral closed-wedge HTO (CWHTO), and hybrid CWHTO were performed by setting the percentage of the weight-bearing line (%WBL) at 62% as an optimal alignment. The correction angle differences between the supine and standing radiographs were measured. The virtual %WBL (v%WBL) was determined by applying the correction angle obtained from the standing radiograph to the supine radiograph. The %WBL discrepancy (%WBLd) was calculated as v%WBL - 62 (%) to predict the possible correction errors during surgeries. A single regression analysis was performed to examine the correlation between the correction angle difference and %WBLd. RESULTS: The mean correction angle was significantly higher when the preoperative planning was based on standing radiographs than when based on supine radiographs (P < 0.001), and the mean difference was 2.2 ± 1.5°. The difference between the two conditions in the medial opening gaps for OWHTO, lateral wedge sizes (mm) for CWHTO, and hybrid CWHTO were 2.6 ± 2.0, 2.3 ± 1.6, and 1.9 ± 1.4, respectively. The mean v%WBL was 71.2% ± 7.3%, and the mean %WBLd was 10.1% ± 7.4%. A single regression analysis revealed a linear correlation between the correction angle difference and %WBLd (%WBLd = 4.72 × correction angle difference + 0.08). No statistically significant difference in the parameters was found between the supine and standing radiographs postoperatively. CONCLUSIONS: We found significant differences in the estimated correction angles between the supine and standing radiographs in the planning for HTO. Therefore, surgeons should carefully consider the difference between supine and standing radiographs and estimate the possible correction error during surgery when planning a HTO.

  Mar. 2021, Knee surgery & related research, 33(1) (1), 8 - 8, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effects of ultrasound, radial extracorporeal shock waves, and electrical stimulation on rat bone defect healing.

  Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama

  Fractures associated with osteoporosis are a major public health concern. Current treatments for fractures are limited to surgery or fixation, leading to long-term bedrest, which is linked to increased mortality. Alternatively, utilization of physical agents has been suggested as a promising therapeutic approach for fractures. Here, we examined the effects of ultrasound, radial extracorporeal shock waves, and electrical stimulation on normal or osteoporotic fracture healing. Femoral bone defects were created in normal or ovariectomized rats. Rats were divided into four groups: untreated, and treated with ultrasound, shock waves, or electrical stimulation after surgery. Samples were collected at 2 or 4 weeks after surgery, and the healing process was evaluated with micro-CT, histological, and immunohistochemical analyses. Ultrasound at intensities of 0.5 and 1.0 W/cm2 , but not 0.05 W/cm2 , accelerated new bone formation. Shock wave exposure also increased newly formed bone, but formed abnormal periosteal callus around the defect site. Conversely, electrical stimulation did not affect the healing process. Ultrasound exposure increased osteoblast activity and cell proliferation and decreased sclerostin-positive osteocytes. We demonstrated that higher-intensity ultrasound and radial extracorporeal shock waves accelerate fracture healing, but shock wave treatment may increase the risk of periosteal callus formation.

  Feb. 2021, Annals of the New York Academy of Sciences, 1497(1) (1), 3 - 14, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Quantitative bone single-photon emission computed tomography imaging for uninfected nonunion: comparison of hypertrophic nonunion and non-hypertrophic nonunion.

  Keisuke Oe, Feibi Zeng, Tomoaki Fukui, Munenobu Nogami, Takamichi Murakami, Tomoyuki Matsumoto, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Recently, a standardized uptake value (SUV) has been used to evaluate bone single-photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected nonunion to compare hypertrophic nonunion and non-hypertrophic nonunion using volume-based parameters. METHODS: We evaluated 23 patients with uninfected nonunion who underwent SPECT acquisition 3 h after an injection of 99mTc-hydroxymethylene diphosphonate or 99mTc-methylene diphosphonate from April 2014 to November 2019. We reconstructed the acquired data and performed voxel-based quantitative analysis using the GI-BONE software. Quantitative parameters, maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean) in the high and low uptake areas of nonunion were compared between hypertrophic nonunion and non-hypertrophic nonunion. The contralateral limb was used as a control, and the ratios of the quantitative parameters were calculated. RESULTS: The values for the quantitative parameters (high uptake area/low uptake area, respectively), SUVmax control ratio (12.13 ± 4.95/6.44 ± 4.71), SUVpeak control ratio (11.65 ± 4.58/6.45 ± 4.64), and SUVmean control ratio (11.94 ± 5.03/6.28 ± 4.95) for hypertrophic nonunion were higher than those for non-hypertrophic nonunion (7.82 ± 4.76/3.41 ± 2.09 (p = 0.065/0.12), 7.56 ± 4.51/3.61 ± 2.23 (p = 0.065/0.22), and 7.59 ± 5.18/3.05 ± 1.91 (p = 0.076/0.23)). CONCLUSIONS: SUVmax, SUVpeak, and SUVmean control ratios obtained from bone SPECT images can quantitatively evaluate the biological activity of nonunions and may be an effective evaluation method for treatment decisions, especially the necessity of autologous bone grafting.

  Feb. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 125 - 125, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Cryopreserved human adipose-derived stromal vascular fraction maintains fracture healing potential via angiogenesis and osteogenesis in an immunodeficient rat model.

  Tomoyuki Kamenaga, Yuichi Kuroda, Kanto Nagai, Masanori Tsubosaka, Yoshinori Takashima, Kenichi Kikuchi, Masahiro Fujita, Kemmei Ikuta, Kensuke Anjiki, Toshihisa Maeda, Naoki Nakano, Koji Takayama, Shingo Hashimoto, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: Novel therapeutic strategies for the healing of nonunion, which has serious effects on the quality of life of patients, are needed. We evaluated the therapeutic effect of local transplantation of human stromal vascular fraction (SVF) cells on fracture healing in a rat non-healing fracture model and compared the effects between freshly isolated (F) and cryopreserved (C)-SVFs. METHODS: Non-healing fracture model was induced in the femur of female immunodeficient rats (F344/N Jcl rnu/rnu) with cauterizing periosteum. Immediately after the creation of non-healing fracture, rats received local transplantation of F and C-SVFs suspended in phosphate-buffered saline (PBS) or the same volume of PBS without cells using the same scaffold as a control group. During 8 weeks post-surgery, radiologic, histological, immunohistochemical, and biomechanical analyses were performed to evaluate fracture healing. The comparison of radiological results was performed with a chi-square test, and the multiple comparisons of immunohistochemical, histological, and biomechanical results among groups were made using a one-way analysis of variance. A probability value of 0.05 was considered to denote statistical significance. RESULTS: At week 8, in 60% of animals receiving F-SVF cells and in 50% of animals receiving C-SVF cells, the fracture radiologically healed with bone union whereas nonunion was observed in the control group. The healing potential was also confirmed by histological and biomechanical assessments. One of the mechanisms underlying healing involving intrinsic angiogenesis/osteogenesis was enhanced in F- and C-SVF groups compared with that in the control group. Human cell-derived vasculogenesis/osteogenesis, which was also confirmed in an in vitro differentiation assay, was also enhanced in the F- and C-SVF groups compared with that in the control groups and could be another mechanism for healing. CONCLUSIONS: SVF cells can enhance bone healing and cryopreserved cells have almost equal potential as fresh cells. SVF cells can be used for improving nonunion bone fracture healing as an alternative to other mesenchymal stem cells and the effect of SVF cells can be maintained under cryopreservation.

  Feb. 2021, Stem cell research & therapy, 12(1) (1), 110 - 110, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Mid-flexion stability in the anteroposterior plane is achieved with a medial congruent insert in cruciate-retaining total knee arthroplasty for varus osteoarthritis.

  Masanori Tsubosaka, Kazunari Ishida, Kazuki Kodato, Nao Shibanuma, Shinya Hayashi, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: This study aimed to compare the intraoperative kinematics, especially for mid-flexion femorotibial anteroposterior (AP) stability, between newly developed medial congruent (MC) inserts and cruciate-retaining (CR) inserts in navigated cruciate-retaining total knee arthroplasty (CR-TKA). METHODS: Thirty consecutive patients with varus osteoarthritis undergoing CR-TKA using an image-free navigation system were enrolled. AP kinematics, the AP translation under manual maximum stress to the knee joint at 45° flexion, rotational kinematics, and varus-valgus laxity were evaluated using a navigation system and statistically compared between the MC and CR inserts. RESULTS: AP kinematic analysis showed that the femoral position with the CR insert was significantly anterior at a maximum extension to 45° flexion compared with the MC insert (p < 0.05). The amount of AP translation at 45° flexion with the MC insert was significantly smaller than that with the CR insert (p < 0.05). Rotational kinematics found that the tibial position at maximum extension was significantly externally rotated with the MC inserts than with the CR inserts. Varus-valgus laxity was comparable between the MC and CR inserts. CONCLUSION: The current results showed that greater mid-flexion AP stability was achieved with the MC inserts than with the CR inserts in CR-TKA. Intraoperative kinematics with the MC inserts more closely resembled those with preoperative conditions in CR-TKA. LEVEL OF EVIDENCE: III, prospective comparative study.

  Feb. 2021, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 29(2) (2), 467 - 473, English, International magazine

  Scientific journal


• The sagittal cutting plane affects evaluation of the femoral bone tunnel position on three-dimensional computed tomography after anterior cruciate ligament reconstruction.

  Nobuaki Miyaji, Daisuke Araki, Yuichi Hoshino, Noriyuki Kanzaki, Kanto Nagai, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda, Takehiko Matsushita

  PURPOSE: To investigate how the femoral sagittal cutting plane affects evaluation of the bone tunnel position after anterior cruciate ligament (ACL) reconstruction using the quadrant method in three-dimensional computed tomography (CT) imaging. METHODS: Thirty patients who underwent primary anatomic double-bundle ACL reconstruction and CT 2 weeks after surgery were enrolled. Three sagittal cutting planes with respect to the condylar axis were created using the CT images: at the top of the intercondylar notch (C-plane), 5% medial (M-plane), and 5% lateral (L-plane). The center of the bone tunnel position regarding depth and height of the anteromedial (AMB) and posterolateral bundle (PLB) were quantitatively evaluated using the quadrant method on the three different planes. RESULTS: The mean depths of AMB and PLB were 27.4 ± 4.4% and 39.7 ± 5.1%, 27.0 ± 4.2% and 37.6 ± 4.9%, and 27.4 ± 4.5% and 38.5 ± 6.0%, at the M, C and L planes, respectively. The mean heights of AMB and PLB were 30.8 ± 6.3% and 56.2 ± 5.6%, 30.4 ± 6.2% and 56.6 ± 5.6%, and 25.4 ± 7.0% and 52.9 ± 6.9% at the M, C, and L planes, respectively. Both AMB and PLB bone tunnels were evaluated as higher positions in the L-plane than the C-plane (p < 0.01, p = 0.02, respectively) and M-plane (p < 0.01, p = 0.04, respectively), but there were no significant differences between the C-plane and M-plane (n.s.). There was no significant difference in the anteroposterior direction for all planes. CONCLUSION: In evaluations of the bone tunnel position with the quadrant method using three-dimensional CT, the bone tunnel position depends on the femoral sagittal cutting plane. A consistent evaluation method should be used when evaluating the bone tunnel position after ACL reconstruction to enable correct evaluation clinically. LEVEL OF EVIDENCE: Case-control study, Level III.

  Feb. 2021, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 29(2) (2), 398 - 404, English, International magazine

  Scientific journal


• A Cell-free Biodegradable Synthetic Artificial Ligament for the Reconstruction of Anterior Cruciate Ligament in a Rat Model.

  Yohei Kawakami, Kazuhiro Nonaka, Naomasa Fukase, Antonio D' Amore, Yoichi Murata, Patrick Quinn, Samuel Luketich, Koji Takayama, Kunj G Patel, Tomoyuki Matsumoto, James H Cummins, Masahiro Kurosaka, Ryosuke Kuroda, William R Wagner, Freddie H Fu, Johnny Huard

  Traditional Anterior Cruciate Ligament (ACL) reconstruction is commonly performed using an allograft or autograft and possesses limitations such as donor site morbidity, decreased range of motion, and potential infection. However, a biodegradable synthetic graft could greatly assist in the prevention of such restrictions after ACL reconstruction. In this study, artificial grafts were generated using "wet" and "dry" electrospinning processes with a biodegradable elastomer, poly (ester urethane) urea (PEUU), and were evaluated in vitro and in vivo in a rat model. Four groups were established: (1) Wet PEUU artificial ligament, (2) Dry PEUU artificial ligament, (3) Dry polycaprolactone artificial ligament (PCL), and (4) autologous flexor digitorum longus tendon graft. Eight weeks after surgery, the in vivo tensile strength of wet PEUU ligaments had significantly increased compared to the other synthetic ligaments. These results aligned with increased infiltration of host cells and decreased inflammation within the wet PEUU grafts. In contrast, very little cellular infiltration was observed in PCL and dry PEUU grafts. Micro-computed tomography analysis performed at 4 and 8 weeks postoperatively revealed significantly smaller bone tunnels in the tendon autograft and wet PEUU groups. The Wet PEUU grafts served as an adequate functioning material and allowed for the creation of tissues that closely resembled the ACL.

  Feb. 2021, Acta biomaterialia, 121, 275 - 287, English, International magazine

  Scientific journal


• Clinical Outcome of the Patients With Brain Metastasis from Soft Tissue Sarcomas.

  Toshiyuki Takemori, Teruya Kawamoto, Masayuki Morishita, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Takuya Fujimoto, Ikuo Fujita, Yutaka Mifune, Yuichi Hoshino, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue

  BACKGROUND/AIM: This study aimed to evaluate the association of clinical characteristics with treatment outcomes to ascertain the appropriate treatment options for soft tissue sarcomas (STS) patients with brain metastasis (BM). PATIENTS AND METHODS: Medical records of STS patients with BM who were treated in our institutions were retrospectively reviewed, and analyzed to identify the factors associated with post-BM survival. RESULTS: Among the 509 STS patients, BM occurred in five patients (0.98%). The median survival after BM was 1.5 months. Histological subtypes of the primary lesions in the five BM patients were: two synovial sarcomas, one myxoid liposarcoma, one alveolar soft part sarcoma, and one rhabdomyosarcoma. Among the five BM patients, the post-BM survival of two patients, who underwent surgery and postoperative radiotherapy, was longer than that of the other patients (p<0.01). CONCLUSION: Combined surgery and postoperative radiotherapy effectively managed symptoms and prolonged survival in STS patients with BM.

  Feb. 2021, Anticancer research, 41(2) (2), 1027 - 1034, English, International magazine

  Scientific journal


• Obesity is associated with less favorable outcomes following hip arthroscopic surgery: a systematic review and meta-analysis.

  Yuichi Kuroda, Shingo Hashimoto, Masayoshi Saito, Shinya Hayashi, Naoki Nakano, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: The aim of this study was to systematically review the existing literature comparing the postoperative outcomes after following hip arthroscopy in obese and non-obese patients. METHODS: Studies comparing the outcomes following hip arthroscopy of obese and non-obese patients were systematically identified via a computer-assisted literature search of Pubmed (Medline), EMBASE, and Cochrane Library using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Studies comparing the outcome of hip arthroscopy in different body mass index (BMI) groups were included. Data including patient-reported outcome measures (PROMs), revision arthroscopy rate, conversion rate to total hip arthroplasty (THA), and complications were collected. The methodological index for non-randomized studies (MINORS) and Newcastle-Ottawa Scale (NOS) were used to assess the quality of each study quality. The effect of heterogeneity was quantified by calculating the I2 value. RESULTS: A total of eight studies were finally included in the qualitative analysis, and three studies of high quality involving 373 hips were included in the quantitative assessment. All the studies defined obesity as a BMI of  ≥ 30 kg/m2. The modified Harris Hip Score and the Non-Arthritic Hip Score were 5.1 (95% CI 1.1-9.1) and 9.0 (95% CI 5.0-13.1) points lower, respectively, in the obese group than in the non-obese group. The pooled odds ratios were 1.2 (95% CI 0.5-2.7) for revision arthroscopy, 2.4 (95% CI 1.3-4.6) for conversion to THA, and 3.2 (95% CI 1.2-8.6 for complications in favor of the non-obese group. The heterogeneity was low in all outcome assessments (I2 0-18%). CONCLUSION: Obese patients had significantly lower PROMs than non-obese patients following hip arthroscopic surgery, and the THA conversion and complication rates were 2.4 times and 3.2 times higher, respectively. Understanding the effect of obesity on hip arthroscopy will allow appropriate surgical indications for surgery to be further refined and help obese patients to understand their individual risk profile. LEVEL OF EVIDENCE: Systematic review of Level III-IV studies, Level IV.

  Jan. 2021, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 29(5) (5), 1483 - 1493, English, International magazine

  Scientific journal


• Anatomic double-bundle anterior cruciate ligament reconstruction could not achieve sufficient control of pivot-shift when accompanying tibial tunnel coalition.

  Koji Nukuto, Yuichi Hoshino, Tetsuya Yamamoto, Nobuaki Miyaji, Kanto Nagai, Daisuke Araki, Noriyuki Kanzaki, Takehiko Matsushita, Ryosuke Kuroda

  PURPOSE: To evaluate the effect of tibial tunnel coalition on knee rotatory laxity and clinical outcomes after double-bundle (DB) anterior cruciate ligament (ACL) reconstruction. METHODS: Forty-one patients who underwent anatomic DB ACL reconstruction were included prospectively. Three-dimensional computed tomography of the knee joint was obtained at approximately 1 year postoperatively to determine if tunnel coalition occurred. After excluding seven cases of femoral tunnel coalition, two groups were established based on the existence of a tibial tunnel coalition. The pivot-shift test was quantitatively evaluated on the basis of tibial acceleration preoperatively and at 1 year postoperatively. Two subjective scores, the International Knee Documentation Committee (IKDC) subjective and Lysholm scores, were also collected. The pivot-shift measurement and subjective scores were compared between the ACL-reconstructed knees with and without tibial tunnel coalition. The independent t test, Pearson's chi-square test, and Student t tests were used in data analysis. RESULTS: Twenty-one knees had tibial tunnel coalition (group C), whereas 13 knees did not have tunnel coalition(group N). Pivot-shift was significantly diminished postoperatively in both groups on the basis of the clinical examination and quantitative evaluations (p < 0.05). However, there was a small but significant difference in tibial acceleration demonstrating larger pivot-shift in group C (1.0 ± 0.6 m/s2) than in group N (0.5 ± 0.3 m/s2, p < 0.05). No significant difference was observed in the IKDC subjective and Lysholm scores (both n.s.). CONCLUSION: When the tibial tunnel coalition occurs after DB ACL reconstruction, knee rotatory laxity may not be restored in ACL-reconstructed knees, as expected in those without tunnel coalition. It is recommended that two tibial tunnels should be created separately when performing DB-ACL reconstruction to achieve better control of rotatory knee laxity. LEVEL OF EVIDENCE: III.

  Jan. 2021, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 膝前十字靱帯再建術後のスポーツ復帰と膝関節機能および心理的要因の相互関連性

  上田 雄也, 松下 雄彦, 柴田 洋平, 三浦 大祐, 瀧口 耕平, 小野 くみ子, 小野 玲, 長井 寛斗, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (一社)日本スポーツ理学療法学会, 2021, スポーツ理学療法学, 1(Suppl.) (Suppl.), OS - 03, Japanese


• The quantitative evaluation of anterior drawer test using an electromagnetic measurement system

  Kiminari Kataoka, Yuichi Hoshino, Kouki Nagamune, Koji Nukuto, Tetsuya Yamamoto, Takahiro Yamashita, Noriyuki Kanzaki, Kenichiro Kakutani, Takehiko Matsushita, Ryosuke Kuroda

  Routledge, 2021, Sports Biomechanics, English

  Scientific journal


• Intra-medullary antibiotics perfusion (iMAP) for the control of fracture-related infection early after osteosynthesis.

  Akihiro Maruo, Takahiro Oda, Hidetoshi Miya, Hirotsugu Muratsu, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Takahiro Niikura

  PURPOSE: In our hospital, cases of bone and soft tissue infections have been treated with continuous local antibiotics perfusion that allows for continuous circulation of antibiotics throughout the infected lesion. We termed this treatment "intramedullary antibiotics perfusion (iMAP)" for bone infection such as fracture-related infection (FRI) and "intrasoft tissue antibiotics perfusion" for soft tissue infection. Many cases are treated with both modalities. To introduce iMAP, this study focused on the patients with FRI treated with iMAP and reviewed their treatment outcomes. METHODS: We included 10 patients with FRI treated with iMAP between 2004 and 2017. The iMAP needles were inserted near the infected lesion, and an aminoglycoside antimicrobial was continuously administered. Patient characteristics, pathogenic bacteria, administered antibiotics, duration of administration, concentrations of antibiotics in blood and leachate fluid, fracture union rate, implant retention rate, and complications were studied. RESULTS: The mean age of patients was 59.9 years, and the mean follow-up period was 2.5 years. Affected bones were the tibia (n = 8), humerus (n = 1), and fibula (n = 1). Deep infections developed on average 29.9 days after osteosynthesis. Pathogenic bacteria were methicillin-susceptible Staphylococcus aureus (n = 6), methicillin-resistant S. aureus (n = 2), and unknown (n = 2). Average iMAP duration was 17.1 days. In all patients, infection was eradicated while preserving the implants, and fracture union was achieved without complications. CONCLUSION: iMAP is a novel local drug delivery system allowing high concentrations of antibiotics to be administered without complications and is useful in the treatment of FRI.

  2021, Journal of orthopaedic surgery (Hong Kong), 29(3) (3), 23094990211051492 - 23094990211051492, English, International magazine

  Scientific journal


• 非感染性偽関節に対する骨SPECTの定量評価(Quantitative evaluation of bone SPECT for uninfected nonunion)

  曽 菲比, 大江 啓介, 野上 宗伸, 犬養 純子, 立花 美保, 久保 和広, 福井 友章, 新倉 隆宏, 黒田 良祐, 村上 卓道

  (一社)日本核医学会, 2021, 核医学, 58(Suppl.) (Suppl.), S198 - S198, English


• 非感染性偽関節に対する骨SPECTの定量評価(Quantitative evaluation of bone SPECT for uninfected nonunion)

  曽 菲比, 大江 啓介, 野上 宗伸, 犬養 純子, 立花 美保, 久保 和広, 福井 友章, 新倉 隆宏, 黒田 良祐, 村上 卓道

  (一社)日本核医学会, 2021, 核医学, 58(Suppl.) (Suppl.), S198 - S198, English


• On Degree of Bone Healing for Bone Fracture Treatment by Ultrasonic Wave.

  Takumi Ueyama, Yohei Kumabe, Keisuke Oe, Tomoaki Fukui, Takahiro Niikura, Ryosuke Kuroda, Masakazu Morimoto, Naomi Yagi, Yutaka Hata

  IEEE, 2021, ICMLC, 1 - 5

  International conference proceedings


• 骨端線閉鎖前の習慣性膝蓋骨脱臼に対してproximal realignment法と内側膝蓋大腿靱帯再建術の併用により良好な成績を得た一例

  渡邉 秀, 松下 雄彦, 長井 寛斗, 荒木 大輔, 星野 祐一, 神崎 至幸, 黒田 良祐

  関西関節鏡・膝研究会, 2021, 関西関節鏡・膝研究会誌, 33(1) (1), np7 - np9, Japanese


• A Case of Femoral Neck Insufficiency Fracture due to Tumor-Induced Osteomalacia.

  Yu Inoue, Tomoaki Fukui, Keisuke Oe, Shinya Hayashi, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Tumor-induced osteomalacia (TIO) is a rare skeletal disease caused by hypersecretion of fibroblast growth factor 23 (FGF-23) from neoplasms of mesenchymal origin; patients with TIO present with insufficiency fractures, progressive bone pain, and delayed fracture unions. Herein, we report the case of a 48-year-old man with an insufficiency fracture in his left femoral neck associated with TIO. The causative tumor located in the patient's maxillary sinus had been resected; however, complete resection was impossible due to the location of the tumor. Therefore, the patient's osteomalacia persisted, and he experienced a left femoral neck fracture in the absence of severe trauma. Because delayed fracture union was anticipated in this patient, we performed an internal fixation using an implant with a lateral plate for angular stability and multiple screws for rotational stability. Although fracture union took 15 months, the patient's postoperative course was uneventful, and he could walk without any symptoms or assistance at his most recent follow-up 30 months after surgery. In TIO, hypersecretion of FGF-23 leads to increased renal excretion of phosphorus, increased bone resorption of calcium and phosphorus, decreased osteoblastic bone mineralization, and decreased gastrointestinal absorption of calcium and phosphorus, leading to insufficiency fractures and delayed fracture unions. Diagnosis of TIO is often delayed due to its rarity and vague symptoms. Total resection of the causative tumor is the optimal treatment; however, in cases wherein complete tumor resection is impossible, drug therapy may be insufficient, and the underlying TIO pathology, including bone fragility, may persist. Early diagnosis of TIO is important for preventing insufficiency fractures; however, when fractures are unavoidable, the surgical treatment of femoral neck fractures in patients with osteomalacia should account for a longer time frame for complete fracture union and therefore utilize implants with sufficient stability.

  2021, Case reports in orthopedics, 2021, 6668006 - 6668006, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 【超音波による骨折治療】偽関節に対する超音波治療

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  金原出版(株), Jan. 2021, 整形・災害外科, 64(1) (1), 61 - 69, Japanese


• Closed Compression Nailing Using a New-Generation Intramedullary Nail without Autologous Bone Grafting for Humeral Shaft Nonunion.

  Genta Fukumoto, Tomoaki Fukui, Keisuke Oe, Atsuyuki Inui, Yutaka Mifune, Ryosuke Kuroda, Takahiro Niikura

  Introduction: Although the recommended treatment for humeral shaft nonunion is compression plating with autologous bone grafting, we treated a case of humeral shaft nonunion with an intramedullary nail (IMN) without bone grafting. Presentation of Case. Osteosynthesis with IMN was performed on a 24-year-old man with a humeral shaft fracture at another hospital. However, bony union was not obtained 1 year after the first surgery, and he was referred to our institution. We treated the nonunion with exchange nailing without autologous bone grafting using compression function of the nail, leading to bony union at 7 months postoperatively. At the final follow-up 2 years and 4 months postoperatively, the patient had full range of motion in the left shoulder and elbow joints. Discussion. Compression plating with autologous bone grafting is reported to be the gold standard for the treatment of humeral shaft nonunion. IMN is advantageous for minimal invasion; however, the conventional type of IMN cannot apply compression force between fragments and does not have sufficient stability against rotational force. In this case, we used an IMN that could apply compression between the fragments and which had rotational stability via many screws. We did not perform bone grafting because the current nonunion was adjudged to be biologically active, and we achieved good functional results. Conclusion: We treated humeral shaft nonunion using IMN with compression, but without bone grafting, leading to successful clinical outcomes. This strategy might be an appropriate choice for the treatment of humeral shaft nonunion with biological activity.

  2021, Case reports in orthopedics, 2021, 5548729 - 5548729, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 【超音波による骨折治療】偽関節に対する超音波治療

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  金原出版(株), Jan. 2021, 整形・災害外科, 64(1) (1), 61 - 69, Japanese


• Chondrolipoma of the finger in a child: A case study.

  Kazuyoshi Mitani, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Masayuki Morishita, Toshiyuki Takemori, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Masato Komatsu, Naoe Jimbo, Ryosuke Kuroda, Toshihiro Akisue

  Chondrolipoma is, based on the limited case reports available, an extremely rare histological variant of lipoma with the proliferation of mature adipocytes containing an area of true hyaline cartilage. Chondrolipoma is characterized by adult onset and is often identified in the breast, pharynx and tongue. The current study presents a case of chondrolipoma of the finger in an 11 year-old girl. Physical examination indicated a well-defined elastic soft mass, measuring 2.5x2 cm, on the dorsal aspect of the proximal phalanx of the left middle finger. Magnetic resonance imaging (MRI) revealed a well-circumscribed lesion with heterogeneous signal intensity. On T1- and T2-weighted images, the lesion indicated a predominantly marked hyperintense signal containing linear hypointense regions, and on fat-suppressed short-tau inversion recovery sequences, the lesion indicated a predominant hypointensity, with linear regions displaying hyperintensity. Marginal excision of the tumor was performed. Histologically, the major component of the tumor was mature adipose tissue containing a limited area of mature hyaline cartilage matrix, without lipoblasts or malignancy. The postoperative course of the patient was excellent, with no local recurrence three years after surgery. To the best of our knowledge, the current study outlines the first pediatric case of chondrolipoma arising in the finger.

  Jan. 2021, Molecular and clinical oncology, 14(1) (1), 2 - 2, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Impact of joint line orientation on clinical outcomes in bilateral Oxford mobile-bearing unicompartmental knee arthroplasty.

  Ryota Nishida, Takafumi Hiranaka, Tomoyuki Kamenaga, Yuichi Hida, Takaaki Fujishiro, Koji Okamoto, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: Joint line orientation angle (JLOA) is the angle between the knee joint line and the floor. It has been reported to be related to postoperative outcome after TKA. Regarding unicompartmental knee arthroplasty (UKA), although it can be horizontal after UKA because it is a resurfacing surgery, there are few reports about the JLOA after UKA and its impact on clinical outcomes. PURPOSE: The purpose of this study was to reveal the relationship between JLOA and clinical outcome after UKA. METHODS: This study included 106 knees in 53 consecutive patients with osteoarthritis who underwent simultaneous bilateral mobile-bearing UKA. Their pre- and postoperative JLOAs were measured by full-leg-length standing coronal radiographs. We also evaluated the tibial component height (TCH) as the factor which we assumed could influence JLOA. We analyzed the patients' JLOAs, TCHs and clinical outcomes. RESULTS: Pre- and postoperative JLOA were 0.4 ± 2.4° and 2.7 ± 2.6°, respectively. The JLOA significantly tilted medially (P < 0.0001). The JLOA significantly negatively correlated with the improvement of the clinical outcomes (Oxford Knee Score (OKS): r = 0.40, P < 0.0001, Knee Society Knee Score (KSKS): r = 0.25, P < 0.01, Knee Society Function Score (KSFS): r = 0.22, P = 0.02). The TCH showed a positive correlation with postoperative JLOA and with the postoperative JLOA change (r = 0.45, P < 0.001; r = 0.25, P < 0.01, respectively). CONCLUSION: The JLOA significantly tilted medially after UKA. An excessive medial tilt of the JLOA was associated with poorer postoperative outcomes of UKA. It is therefore recommended to keep the JLOA horizontal and to avoid a lower tibial cut.

  Jan. 2021, The Knee, 28, 186 - 193, English, International magazine

  Scientific journal


• Anterior transolecranon fracture dislocation with an associated avulsion fracture of coronoid process of ulna in a child: a case report.

  Kohei Yamaura, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Takeshi Kataoka, Takashi Kurosawa, Shintaro Mukohara, Tomoya Yoshikawa, Takahiro Niikura, Takeshi Kokubu, Ryosuke Kuroda

  Jan. 2021, JSES international, 5(1) (1), 9 - 12, English, International magazine


• Comparison between Single- and Multi-Radius Prostheses Used in Modified Kinematically Aligned Cruciate-Retaining Total Knee Arthroplasty.

  Tomoyuki Matsumoto, Yoshinori Takashima, Koji Takayama, Kazunari Ishida, Naoki Nakano, Yuichi Kuroda, Masanori Tsubosaka, Tomoyuki Kamenaga, Takehiko Matsushita, Takahiro Niikura, Shinya Hayashi, Ryosuke Kuroda

  Kinematically aligned total knee arthroplasty (TKA) has gained interest for achieving more favorable clinical outcomes than mechanically aligned TKA. The present study aimed to compare the clinical outcomes of kinematically aligned TKAs using single-radius (SR) or multi-radius (MR) prostheses. Sixty modified kinematically aligned cruciate-retaining TKAs (30 SR and 30 MR type prostheses) were performed in patients with varus-type osteoarthritis using a navigation system. Intraoperative and postoperative patellar tracking were compared between the two groups. Trochlea shape was also compared between the prostheses and preoperative native anatomy using three-dimensional simulation software. Total 2 years postoperatively, the range of motion and 2011 Knee Society Scores (KSS) were compared between the two groups. There were no differences in patellar maltracking including patellar lateral shift and tilt between the two groups; however, the ratio of intraoperative lateral retinacular release for adjusting patellar tracking was significantly higher in the MR group than in the SR group. Lateral and medial facet heights in both prostheses were understuffed compared with native knee anatomy, while the deepest point of the trochlear groove was significantly more medial in the MR group. The postoperative clinical outcomes showed no significant differences between the two groups. In conclusion, modified kinematically aligned TKAs using a SR or MR prosthesis showed no significant differences in clinical outcomes or patellar tracking when appropriate lateral retinacular release was performed.

  Dec. 2020, The journal of knee surgery, English, International magazine

  Scientific journal


• Effectiveness of an accelerometer-based portable navigation for intraoperative adjustment of leg length discrepancy in total hip arthroplasty in the supine position.

  Kensuke Anjiki, Tomoyuki Kamenaga, Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Takaaki Fujishiro, Takafumi Hiranaka, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: This study aimed to examine the accuracy of the HipAlign® accelerometer-based portable navigation system by measuring the intraoperative leg length change of patients who underwent total hip arthroplasty (THA) and comparing the measured leg length discrepancy (LLD) determined by the navigation system and a freehand technique. METHODS: A total of 61 patients who underwent THA using the anterolateral approach in the supine position were included in this study and divided into two groups: those who underwent THA with navigation (Group N; N = 31) and with the freehand technique (Group F; N = 30). Statistical analyses were performed to compare the intraoperative leg length change, pre- and post-LLD, absolute values of post-LLD, and the number of patients with the postoperative LLD within 10 mm and 5 mm between the two groups. Additionally, we examined the correlation between the leg length change obtained through intraoperative navigation and measured from the radiographs. Moreover, to evaluate the navigation accuracy, we examined the correlation between the absolute error of leg length change and cup orientation. RESULTS: The postoperative LLD was significantly lower and the number of patients with the postoperative LLD within 5 mm was significantly higher in Group N, compared with Group F. Additionally, the amount of leg length change measured intraoperatively by the navigation system was strongly correlated with the values obtained by the postoperative radiographic measurement with a small absolute error and minimal wasted time. Moreover, a significant positive correlation was found between the absolute error of the leg length change and that of the cup inclination. CONCLUSIONS: Our study demonstrates that the accelerometer-based portable navigation system is useful for the intraoperative adjustment of leg length discrepancy during THA for patients in the supine position, as it provides good accuracy and minimizes required time for use.

  Dec. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 27(1) (1), 169 - 175, English, Domestic magazine

  Scientific journal


• Relationship between glenohumeral internal rotation deficit and shoulder conditions in professional baseball pitchers.

  Kohei Yamaura, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Shintaro Mukohara, Tomoya Yoshikawa, Yuichi Hoshino, Takahiro Niikura, Takeshi Kokubu, Ryosuke Kuroda

  BACKGROUND: Previous studies have reported that glenohumeral internal rotation deficit (GIRD) may increase the risk of throwing-shoulder injuries. The purpose of this study was to analyze the conditions of the throwing shoulder in professional baseball pitchers with GIRD by comparing with those in pitchers without GIRD. METHODS: In total, 26 male professional baseball pitchers participated in this study. We evaluated passive range of motion (ROM) and isometric muscle strength at internal rotation (IR) and external rotation (ER) at 90° of abduction, as well as the muscle thickness of the supraspinatus (SSP) and infraspinatus (ISP) by ultrasound. The pitchers were divided into 2 groups: those who exhibited a loss of IR of ≥20° in the throwing shoulder (GIRD group) and those who did not (non-GIRD group). RESULTS: In the GIRD group, the total ROM deficit (throwing side - non-throwing side) (P < .001), the muscle thickness ratio (throwing to non-throwing) of the SSP and ISP (P = .017 and P = .014, respectively), and the muscle strength ratio (throwing to non-throwing) of ER (P = .028) were significantly lower than those in the non-GIRD group. In contrast, the muscle strength ratio (throwing to non-throwing) of IR was significantly higher in the GIRD group than in the non-GIRD group (P = .0064). CONCLUSIONS: We have shown that GIRD has significant correlations with several conditions, such as atrophy of the SSP and ISP, weakness of ER strength, enhancement of IR strength, limitation of total ROM, and throwing side, all of which could be important factors for throwing-shoulder injuries.

  Dec. 2020, Journal of shoulder and elbow surgery, 30(9) (9), 2073 - 2081, English, International magazine

  Scientific journal


• Osteochondritis Dissecans of the Humeral Trochlea Treated with Mosaic-type Osteochondral Autologous Transplantation.

  Yoshifumi Harada, Atsuyuki Inui, Takeshi Kokubu, Yutaka Mifune, Hanako Nishimoto, Ryosuke Kuroda

  Introduction: The majority of osteochondritis dissecans (OCD) of the elbow occurs in the humeral capitellum in adolescence while OCD in the humeral trochlea is relatively rare. We report a rare case of OCD in the humeral trochlea, which underwent mosaic-type osteochondral autologous transplantation. Case Report: A 24-year-old man, who was a gymnastic athlete, complained of severe right elbow pain for 9 years. Image findings revealed a trochlear osteochondral defect with intra-articular loose body. Due to the large defect and duration of the disease, autologous osteochondral transplantation form femoral condyle was performed. Two years after surgery, the range of elbow motion was 0° in extension and 120° in flexion. He had no pain on his elbow. Conclusion: OCD in the humeral trochlea was treated with mosaic-type osteochondral autologous transplantation form femoral condyle. Despite the large trochlear defect, osteochondral transplantation yielded a satisfactory result and this treatment might be an option for treatment of trochlear OCD.

  Dec. 2020, Journal of orthopaedic case reports, 10(9) (9), 106 - 108, English, International magazine


• ディープラーニングによる手根管症候群の超音波画像診断の試み

  乾 淳幸, 西本 華子, 美舩 泰, 山裏 耕平, 向原 伸太郎, 吉川 智也, 篠原 一生, 黒田 良祐

  日本末梢神経学会, Dec. 2020, 末梢神経, 31(2) (2), 279 - 279, Japanese


• 不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する

  平田 悠, 野村 和弘, 新倉 隆宏, 橘 吉寿, 加藤 大輔, 内山 奏, 福井 友章, 大江 啓介, 細岡 哲也, 和氣 弘明, 黒田 良祐, 小川 渉

  日本筋学会, Dec. 2020, 日本筋学会学術集会プログラム・抄録集, 6回, 46 - 46, Japanese


• 高齢者に対するPS-TKA術後1年の患者満足度と他の患者立脚型評価との相関

  玉岡 拓也, 村津 裕嗣, 栖田 慶仁, 井上 悠, 大月 悠平, 井口 貴雄, 古賀 敬章, 松本 知之, 圓尾 明弘, 宮 秀俊, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2020, 日本人工関節学会誌, 50, 11 - 12, Japanese


• CR-TKAにおける術後下肢前額面アライメントが術後膝関節安定性に及ぼす影響

  栖田 慶仁, 村津 裕嗣, 玉岡 拓也, 井上 悠, 大月 悠平, 井口 貴雄, 古賀 敬章, 松本 知之, 圓尾 明弘, 宮 秀俊, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2020, 日本人工関節学会誌, 50, 211 - 212, Japanese


• Risk factors of thigh pain following total hip arthroplasty with short, tapered-wedge stem.

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Takahiro Niikura, Ryosuke Kuroda

  PURPOSE: The occurrence of thigh pain following cementless total hip arthroplasty (THA) may be dependent on multiple factors, which may differ with design of the prosthesis. Thus, this study aimed to investigate the frequency of thigh pain following cementless THA using a short, tapered-wedge stem to identify risk factors for thigh pain. METHODS: This retrospective cohort study analysed 222 joints of patients who underwent THA with a short, tapered-wedge stem. Thigh pain was evaluated using a questionnaire during each follow-up visit, and the clinical and radiographic assessments were compared. RESULTS: Thigh pain occurred in 37 patients (16.7%) during the follow-up period. The pain started two to 24 months after THA. Multivariate analysis demonstrated that higher University of California, Los Angeles, activity rating (odds ratio 7.2; 95% confidence interval (CI) 3.0-17.2); Dorr type C femoral bone shape (odds ratio 1.5; 95% CI 1.1-2.0); and stem tip-cortical bone contact (odds ratio 8.2; 95% CI 2.3-29.4) were significant risk factors of thigh pain following THA. Post-operatively, cortical hypertrophy at Gruen zone 4 was significantly found in patients with thigh pain (p value = 0.032). CONCLUSION: Risk factors of pain following THA with short, tapered-wedge stem were high activity level, Dorr type C femoral bone shape, and stem tip contacting the distal bone surface. Moreover, post-operative cortical hypertrophy at the distal stem tip significantly increased the incidence of thigh pain. Therefore, we must pay attention to the aforementioned factors to avoid post-operative thigh pain when using a short, tapered-wedge stem.

  Dec. 2020, International orthopaedics, 44(12) (12), 2553 - 2558, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Extent of in vivo sagittal bearing movement and its relationship with tibial posterior slopes in Oxford mobile-bearing unicompartmental knee arthroplasty.

  Tomoyuki Kamenaga, Yuichi Hida, Takafumi Hiranaka, Toshikazu Tanaka, Kenjiro Okimura, Masanori Tsubosaka, Yuichi Kuroda, Naoki Nakano, Shinya Hayashi, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: The effect of increased tibial slope on the bearing movement and clinical results in mobile-bearing unicompartmental knee arthroplasty has not been well discussed. We aimed to clarify the extent of in vivo sagittal bearing movement and bearing overhang using fluoroscopy and their relationship with the tibial posterior slopes and clinical results. METHODS: This retrospective study included 40 patients who underwent Oxford unicompartmental knee arthroplasty for anteromedial osteoarthritis or osteonecrosis of the knee. Intraoperative posterior translation and posterior overhang of the bearing were assessed during flexion. The tibial posterior slopes were evaluated before and 2 weeks after surgery, and its increment was recorded. Clinical evaluations were also performed preoperatively and at 2 years postoperatively (maximum flexion angle, Oxford Knee Score). Single linear regression analysis was performed to assess the correlation between the tibial posterior slopes and the posterior translation and the posterior overhang and determine if these could affect the clinical outcomes. FINDINGS: The average posterior translation was 10.7 ± 4.3 mm, and posterior overhang of the mobile bearing was found in 35% of overall patients. They were associated with increased tibial slope as well as poorer improvement in Oxford Knee Score at 2 years postoperatively. INTERPRETATION: In Oxford unicompartmental knee arthroplasty, mobile bearing can probably move posteriorly beyond the posterior margin of the tibial component during flexion when the tibial posterior slope increases more than the original magnitude. Additionally, the posterior translation and posterior overhang closely correlated with the poorer improvement in Oxford Knee Score at 2 years postoperatively.

  Dec. 2020, Clinical biomechanics (Bristol, Avon), 80, 105148 - 105148, English, International magazine

  Scientific journal


• Boron neutron capture therapy for clear cell sarcoma.

  Takuya Fujimoto, Minoru Suzuki, Tamotsu Sudo, Ikuo Fujita, Toshiko Sakuma, Yoshinori Sakurai, Takanori Hirose, Masayuki Morishita, Takushi Takata, Yuki Tamari, Hiroki Tanaka, Tooru Andoh, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Rika Shigemoto, Tomoyuki Matsumoto, Hideki Ichikawa, Koji Ono, Ryosuke Kuroda, Toshihiro Akisue

  Clear cell sarcoma of tendons and aponeuroses (CCS) is a rare, malignant tumor arising in lower extremities with no effective treatment other than wide surgical resection. Here described is a case of primary CCS in the peroneal tendon of the right foot of a 54-year-old woman enrolled to undergo BNCT. The tumor mass post-BNCT disappeared totally without damage to other normal tissue, demonstrating, for the first time, the potential efficacy of BNCT in complete local control of CCS.

  Dec. 2020, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 166, 109324 - 109324, English, International magazine

  Scientific journal


• Prospective cohort study of surgical outcome for spinal metastases in patients aged 70 years or older.

  Yutaro Kanda, Kenichiro Kakutani, Yoshitada Sakai, Takashi Yurube, Shingo Miyazaki, Toru Takada, Yuichi Hoshino, Ryosuke Kuroda

  AIMS: With recent progress in cancer treatment, the number of advanced-age patients with spinal metastases has been increasing. It is important to clarify the influence of advanced age on outcomes following surgery for spinal metastases, especially with a focus on subjective health state values. METHODS: We prospectively analyzed 101 patients with spinal metastases who underwent palliative surgery from 2013 to 2016. These patients were divided into two groups based on age (< 70 years and ≥ 70 years). The Eastern Cooperative Oncology Group (ECOG) performance status (PS), Barthel index (BI), and EuroQol-5 dimension (EQ-5D) score were assessed at study enrolment and at one, three, and six months after surgery. The survival times and complications were also collected. RESULTS: In total, 65 patients were aged < 70 years (mean 59.6 years; 32 to 69) and 36 patients were aged ≥ 70 years (mean 75.9 years; 70 to 90). In both groups, the PS improved from PS3 to PS1 by spine surgery, the mean BI improved from < 60 to > 80 points, and the mean EQ-5D score improved from 0.0 to > 0.7 points. However, no significant differences were found in the improvement rates and values of the PS, BI, and EQ-5D score at any time points between the two groups. The PS, BI, and EQ-5D score improved throughout the follow-up period in approximately 90% of patients in each group. However, the improved PS, BI, and EQ-5D scores subsequently deteriorated in some patients, and the redeterioration rate of the EQ-5D was significantly higher in patients aged ≥ 70 than < 70 years (p = 0.027). CONCLUSION: Palliative surgery for spinal metastases improved the PS, activities of daily living, and quality of life, regardless of age. However, clinicians should be aware of the higher risk of redeterioration of the quality of life in advanced-age patients. Cite this article: Bone Joint J 2020;102-B(12):1709-1716.

  Dec. 2020, The bone & joint journal, 102-B(12) (12), 1709 - 1716, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Transcutaneous CO2 application accelerates fracture repair in streptozotocin-induced type I diabetic rats.

  Takahiro Oda, Takahiro Niikura, Tomoaki Fukui, Keisuke Oe, Yu Kuroiwa, Yohei Kumabe, Kenichi Sawauchi, Ryo Yoshikawa, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Teruya Kawamoto, Yoshitada Sakai, Toshihiro Akisue, Ryosuke Kuroda

  INTRODUCTION: Diabetes mellitus (DM) negatively affects fracture repair by inhibiting endochondral ossification, chondrogenesis, callus formation, and angiogenesis. We previously reported that transcutaneous CO2 application accelerates fracture repair by promoting endochondral ossification and angiogenesis. The present study aimed to determine whether CO2 treatment would promote fracture repair in cases with type I DM. RESEARCH DESIGN AND METHODS: A closed femoral shaft fracture was induced in female rats with streptozotocin-induced type I DM. CO2 treatment was performed five times a week for the CO2 group. Sham treatment, where CO2 was replaced with air, was performed for the control group. Radiographic, histologic, genetic, and biomechanical measurements were taken at several time points. RESULTS: Radiographic assessment demonstrated that fracture repair was induced in the CO2 group. Histologically, accelerated endochondral ossification and capillary formation were observed in the CO2 group. Immunohistochemical assessment indicated that early postfracture proliferation of chondrocytes in callus was enhanced in the CO2 group. Genetic assessment results suggested that cartilage and bone formation, angiogenesis, and vasodilation were upregulated in the CO2 group. Biomechanical assessment revealed enhanced mechanical strength in the CO2 group. CONCLUSIONS: Our findings suggest that CO2 treatment accelerates fracture repair in type I DM rats. CO2 treatment could be an effective strategy for delayed fracture repair due to DM.

  Dec. 2020, BMJ open diabetes research & care, 8(2) (2), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Soft tissue tumor with novel NR1D1-MAML1 fusion in a pediatric case.

  Masato Komatsu, Nobuyuki Yamamoto, Teruya Kawamoto, Yohei Kawakami, Hitomi Hara, Suguru Uemura, Noriyuki Nishimura, Toshihiro Akisue, Ryosuke Kuroda, Kazumoto Iijima, Naoe Jimbo, Maki Kanzawa, Kazuyoshi Kajimoto, Tomoo Itoh, Takanori Hirose

  We herein describe soft tissue tumor arising in the lower extremity of a pediatric patient. The tumor displayed a unique and wide range of histological features, sheet-like and cohesive growth pattern consisting of enlarged round to epithelioid atypical cells with a large alveolar and pseudopapillary histological architecture, focally mimicking alveolar soft part sarcoma and MiT family translocation renal cell carcinoma. Tumor cells were focally immunoreactive for cytokeratin, S-100, and EMA. RNA sequencing identified a novel in-frame NR1D1 (exon 5)-MAML1 (exon 2) gene rearrangement resulting in the formation of a putative chimeric protein containing the N-terminal C4-type zing finger domains of NR1D1 and the C-terminal MAML1 protein, which was confirmed by subsequent RT-PCR, Sanger sequencing, and FISH assay. To the best of our knowledge, NR1D1-MAML1 fusion has not yet been described in any neoplasms, suggesting the emergence of a novel tumor entity.

  Dec. 2020, Virchows Archiv : an international journal of pathology, 477(6) (6), 891 - 895, English, International magazine

  [Refereed]

  Scientific journal


• がんロコモとリハビリテーション医学・医療 がんロコモと骨転移

  原 仁美, 酒井 良忠, 角谷 賢一朗, 竹森 俊幸, 北山 和道, 八尋 俊輔, 秋末 敏宏, 黒田 良祐

  (公社)日本リハビリテーション医学会, Nov. 2020, The Japanese Journal of Rehabilitation Medicine, 57(秋季特別号) (秋季特別号), S195 - S195, Japanese


• 骨転移キャンサーボードを用いたリハビリテーション治療における患者QOLに影響を与える因子の検討

  吉川 遼, 酒井 良忠, 足立 明真, 藤井 康光, 大西 宏和, 松本 健, 倉科 徹郎, 原田 理沙, 原 仁美, 角谷 賢一朗, 新倉 隆宏, 秋末 敏宏, 黒田 良祐

  (公社)日本リハビリテーション医学会, Nov. 2020, The Japanese Journal of Rehabilitation Medicine, 57(秋季特別号) (秋季特別号), S307 - S307, Japanese


• 前十字靱帯再建術前後のリハビリテーション治療 再断裂を防ぐために

  黒田 良祐, 柴田 洋平, 上田 雄也, 瀧口 耕平, 酒井 良忠

  (公社)日本リハビリテーション医学会, Nov. 2020, The Japanese Journal of Rehabilitation Medicine, 57(秋季特別号) (秋季特別号), S141 - S141, Japanese


• 【スポーツ傷害の画像診断】膝内障(十字靱帯、側副靱帯、半月板損傷)の画像診断

  長井 寛斗, 黒田 良祐

  (株)医学出版, Nov. 2020, 月刊レジデント, 13(7) (7), 105 - 114, Japanese


• 高齢者の肘関節脱臼に対してテープ付きアンカーを用いて靱帯修復を行った1例

  元野 紘平, 乾 淳幸, 美舩 泰, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Nov. 2020, 中部日本整形外科災害外科学会雑誌, 63(6) (6), 899 - 900, Japanese


• Ultrasonic Diagnosis for Bone Fracture Healing Process

  Satoshi Kimura, Keisuke Oe, Yohei Kumabe, Tomoaki Fukui, Takahiro Niikura, Ryosuke Kuroda, Naomi Yagi, Yutaka Hata

  IEEE, Nov. 2020, 2020 IEEE 50th International Symposium on Multiple-Valued Logic (ISMVL)

  International conference proceedings


• Unrepaired lateral meniscus tears lead to remaining pivot-shift in ACL-reconstructed knees.

  Yuichi Hoshino, Yuji Hiroshima, Nobuaki Miyaji, Kanto Nagai, Daisuke Araki, Noriyuki Kanzaki, Kenichiro Kakutani, Takehiko Matsushita, Ryosuke Kuroda

  PURPOSE: To compare the postoperative rotatory knee laxity between ACL-reconstructed knees with different meniscus treatments using an electromagnetic pivot-shift measurement. METHODS: Forty-six patients with unilateral ACL reconstructions were enrolled (21 males/25 females, 25 ± 12 y.o.). Concomitant meniscus tears, if any, were repaired whenever possible during primary ACL reconstruction. At 1 year postoperatively, pivot-shift test was performed under anaesthesia during screw removal surgery and quantitatively evaluated by tibial acceleration using an electromagnetic system. The acceleration was compared between ACL-reconstructed knees with different meniscal treatments: intact, repaired and unrepaired. RESULTS: A concomitant meniscus tear was found in 28 knees preoperatively: lateral tears in 11 knees, medial tears in 11 knees and both medial and lateral tears in 6 knees. Postoperatively, 19 ACL-reconstructed knees had a repaired meniscus for either medial, lateral or bilateral menisci tears, and 18 knees had intact menisci pre- and post-operatively. Meanwhile, nine lateral meniscus tears were irreparable and treated by partial meniscectomy or left in situ. ACL-reconstructed knees with unrepaired lateral menisci had significantly larger pivot-shift acceleration (0.9 ± 0.7 m/s2) than those with intact menisci (0.5 ± 0.2 m/s2, p < 0.05), whereas rotatory knee laxity was similar between the knees with fully repaired menisci (0.6 ± 0.3 m/s2) and intact menisci (n.s.). CONCLUSION: An unrepaired lateral meniscus tear in an ACL-reconstructed knee could lead to remaining pivot-shift postoperatively. A concomitant meniscus tear should be repaired during ACL reconstruction to restore normal rotational laxity. LEVEL OF EVIDENCE: Therapeutic Study, Level III.

  Nov. 2020, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 28(11) (11), 3504 - 3510, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Central Implantation of the Femoral Component Relative to the Tibial Insert Improves Clinical Outcomes in Fixed-Bearing Unicompartmental Knee Arthroplasty.

  Tomoyuki Kamenaga, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: The direct relationship between clinical outcomes and femoral component positioning relative to a tibial insert remains unknown. We determined whether the femoral component position relative to the tibial insert could affect clinical outcomes after fixed-bearing unicompartmental knee arthroplasty (UKA). METHODS: The femoral component position relative to the tibial insert of 66 patients with anteromedial osteoarthritis and osteonecrosis of the knee who underwent fixed-bearing UKA was assessed at 2 weeks postoperatively. We classified patients according to the contact point of the femoral component with the tibial component: group M (medial), 18 knees; group C (central), 30 knees; and group L (lateral), 18 knees. Patient-derived clinical scores using the 2011 Knee Society Score were also assessed preoperatively and at 2 years postoperatively and compared among the 3 groups using the analysis of variance. RESULTS: The average 2-year postoperative "symptom" and "patient satisfaction" scores based on the 2011 Knee Society Score were significantly higher in group C than in group M or group L. CONCLUSION: Central implantation of the femoral component relative to the tibial insert plays an important role in decreasing pain and could result in better patient satisfaction after fixed-bearing UKA at 2 years postoperatively. Surgeons should set the femoral component at the center relative to the tibial insert for better patient satisfaction and higher active knee flexion after fixed-bearing UKA.

  Nov. 2020, The Journal of arthroplasty, 35(11) (11), 3108 - 3116, English, International magazine

  Scientific journal


• A Novel Technique of Arthroscopic Ankle Lateral Ligament Repair Using a Knotless Suture Anchor.

  Noriyuki Kanzaki, Nobuaki Chinzei, Takahiro Yamashita, Tsukasa Kumai, Ryosuke Kuroda

  Background: Although arthroscopic lateral ligament repair (ALLR) with suture anchors for chronic lateral ankle instability has become widely accepted, some complications have been reported as well. Establishment of a new technique is essential for better clinical outcomes after ALLR. Purpose: To report a novel technique and good clinical results of ALLR using a knotless suture anchor. Study Design: Case series; Level of evidence, 4. Methods: We examined 30 patients (16 men and 14 women) who underwent ALLR. The mean age of the patients was 30.0 years, and the average period of postoperative monitoring was 21 months. The Japanese Society for Surgery of the Foot (JSSF) ankle-hindfoot scale was used for clinical evaluation postoperatively, and the Self-Administered Foot Evaluation Questionnaire (SAFE-Q) for patient-reported results. Surgical complications were also examined. Results: The JSSF ankle-hindfoot scale showed a significant improvement from preoperatively to follow-up (from 72.1 to 96.1; P < 0.001), and the SAFE-Q was significantly improved in all subscales (pain and pain-related, physical function and daily living, social function, shoe-related, and general health and well-being; P < 0.004 for all). Complications included residual joint pain due to remaining osteophytes in 1 case, scar pain of the accessory anterolateral portal in 2 cases, and positive Tinel sign indicative of superficial peroneal nerve irritation at the anterolateral portal in 1 case. Conclusion: The clinical results of the novel ALLR technique were overall satisfactory. Knot-related complications, one of the main reasons for postoperative complications, were reduced by using a knotless suture anchor.

  Nov. 2020, Orthopaedic journal of sports medicine, 8(11) (11), 2325967120962079 - 2325967120962079, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Algorithms using genome-wide association studies for prediction of effectiveness of biologics in rheumatoid arthritis

  Marowa Hashimoto, Keiko Funahashi, Toshihisa Maeda, Akira Sagawa, Tomomaro Izumihara, Eisuke Shono, Hiroaki Matsuno, Koji Fukuda, Shinya Hayashi, Ryosuke Kuroda, Tsukasa Matsubara

  International Society of Personalized Medicine, Oct. 2020, Personalized Medicine Universe, 9, 20 - 26

  Scientific journal


• Preoperative Condition of the Patellofemoral Joint Does Not Negatively Impact Surgical Outcomes of Lateral Unicompartmental Knee Arthroplasty in the Short Term.

  Masahiro Fujita, Takafumi Hiranaka, Tomoyuki Kamenaga, Masanori Tsubosaka, Naoki Nakano, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  The relationship between patellofemoral joint (PFJ) degeneration and clinical outcomes following lateral unicompartmental knee arthroplasty (UKA) has not been well described thus far. This study aimed to investigate the relationship between the preoperative PFJ condition and postoperative outcomes and the changes in lower-limb and PFJ alignment after lateral UKA. This was a retrospective study including 54 patients (mean age 72.9 years) who underwent lateral UKA for isolated lateral knee osteoarthritis at our institution between March 2013 and January 2019. The Oxford Knee Score (OKS), the Knee Society Score-Knee (KSSK), and Knee Society Score-Function (KSSF), the degree of degeneration, tilting angle and lateral shift of the PFJ, and the hip-knee-ankle angle (HKA) were evaluated pre- and postoperatively. The average follow-up period was 2.8 (range 1-6.1) years. There was a significant improvement in the OKS, KSSK, and KSSF after lateral UKA. Preoperative degeneration of the PFJ did not correlate with the recovery of clinical scores. The degeneration, tilting angle, and lateral shift of the PFJ did not significantly progress following lateral UKA. The HKA was improved after lateral UKA, and there was no correlation between the HKA change and PFJ condition. Postoperative severe valgus knee alignment was associated with a greater tilting angle. Preoperative degeneration of the PFJ did not have a negative impact on postoperative outcomes, and no short-term changes in the degeneration, tilting angle, and lateral shift of the PFJ were observed. Correction of knee-joint alignment did not have a negative impact on the condition of the PFJ.

  Oct. 2020, The journal of knee surgery, 35(7) (7), 810 - 815, English, International magazine

  Scientific journal


• Delayed notochordal cell disappearance through integrin α5β1 mechanotransduction during ex-vivo dynamic loading-induced intervertebral disc degeneration.

  Yutaro Kanda, Takashi Yurube, Yusuke Morita, Yoshiki Takeoka, Takuto Kurakawa, Ryu Tsujimoto, Kunihiko Miyazaki, Yuji Kakiuchi, Shingo Miyazaki, Zhongying Zhang, Toru Takada, Yuichi Hoshino, Koichi Masuda, Ryosuke Kuroda, Kenichiro Kakutani

  The loss of nucleus pulposus (NP) notochordal cells is one of the key initial hallmarks of age-related intervertebral disc degeneration. Although the transmembrane mechanoreceptor integrin α5β1 is important in the process of disc degeneration, the relationship between integrin α5β1 and notochordal cell disappearance remains unclear. The purpose of this study was to elucidate the role of integrin α5β1 in the homeostasis of notochordal cells using an ex-vivo dynamic loading culture system that we developed. Rat tail functional spinal units (n = 80 from 40 rats) were cultured under unloading or 1.3-MPa, 1.0-Hz dynamic compressive loading for 48 or 144 h with or without an integrin α5β1 inhibitor. Disc histomorphology, cell viability, apoptosis, senescence, and phenotypic expression were investigated. Consequently, histological degenerative disc changes with decreased cell viability and increased cell apoptosis and senescence were observed with an extended loading duration. Immunofluorescence revealed that the expression of notochordal cell markers, CD24 and brachyury, and chondrocyte markers, collagen type II and SRY-box 9, declined with loading. In particular, reduction in notochordal cell marker expression was more dramatic than that in chondrocyte marker expression. Apoptotic terminal deoxynucleotidyl transferase dUTP nick-end labeling positivity was also higher in brachyury-positive notochordal cells. Furthermore, all these changes were delayed by inhibiting integrin α5β1. Findings of our dynamic loading regimen with a relatively high pressure suggest reproducibility of the cellularity and phenotypic disappearance of NP notochordal cells during adolescence, the susceptibility of notochordal cells to mechanical stimuli partially through the integrin α5β1 pathway, and future potential treatment of integrin regulation for intervertebral disc disease.

  Oct. 2020, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 39(9) (9), 1933 - 1944, English, International magazine

  Scientific journal


• Predictive factors for effective selection of Interleukin-6 inhibitor and tumor necrosis factor inhibitor in the treatment of rheumatoid arthritis.

  Shinya Hayashi, Tsukasa Matsubara, Koji Fukuda, Keiko Funahashi, Marowa Hashimoto, Toshihisa Maeda, Tomoyuki Kamenaga, Yoshinori Takashima, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda

  Treatment of rheumatoid arthritis (RA) is aimed at long-term remission and inhibition of joint destruction by different biologic drugs. However, the choice of a particular biologic agent based on individual cases of RA remains unestablished. Interleukin-6 (IL-6) inhibitor and tumor necrosis factor (TNF) inhibitor are common biologics used for the treatment of RA. This study aimed to investigate predictive factors for effective selection of tocilizumab (IL-6 inhibitor) and etanercept (TNF inhibitor) in patients with RA. This is a retrospective cohort study. The 196 patients analyzed in this study were divided into four groups: tocilizumab treatment as the first biologic group (TCZ first, 42 patients), tocilizumab as second/ third biologic group (TCZ second, 34 patients), etanercept as the first biologic group (ETN first, 103 patients) and etanercept as second/third group (ETN second, 17 patients). Visual analog scale (VAS), clinical disease activity index (CDAI), and modified health assessment questionnaire (mHAQ) scores at the initiation of biologic treatment and after 6 months of tocilizumab and etanercept therapy were measured and compared to clinical parameters and radiographical parameters among the four groups. CRP, MMP-3, VAS, CDAI, and HAQ were improved after 6 months of treatment in all groups. Improvement of clinical outcomes was correlated with CRP value, duration of RA, and Sharp scores at the initiation of treatment. Multivariate analysis demonstrated improvement in CDAI was significantly associated with the yearly progression of erosion according to the Sharp score in TCZ first group (OR, 1.5; 95% CI, 1.03-2.07) and was negatively associated with the duration of RA (OR, 0.49; 95% CI, 0.29-0.86) at the initiation of treatment with ETN first group. We identified the predictive factors for effective selection of tocilizumab and etanercept treatment and established the effectiveness of tocilizumab for the patients with rapid progressive joint erosion and etanercept for the early administration from diagnosis of RA.

  Oct. 2020, Scientific reports, 10(1) (1), 16645 - 16645, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Acquisition of cancer stem cell properties in osteosarcoma cells by defined factors.

  Shuichi Fujiwara, Teruya Kawamoto, Yohei Kawakami, Yasufumi Koterazawa, Hitomi Hara, Toshiyuki Takemori, Kazumichi Kitayama, Shunsuke Yahiro, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Michiyo Koyanagi-Aoi, Takashi Aoi, Ryosuke Kuroda, Toshihiro Akisue

  BACKGROUND: Cancer stem cells (CSCs) are considered to be responsible for tumor initiation, formation, and poor prognosis of cancer patients. However, the rarity of CSCs in clinical samples makes it difficult to elucidate characteristics of CSCs, especially in osteosarcoma (OS). The aim of this study is to verify whether it is possible to generate CSC-like cells by transducing defined factors into an OS cell line. METHODS: We retrovirally transduced the Octamer-binding transcription factor 3/4 (OCT3/4), Kruppel-like factor 4 (KLF4), and SRY-box transcription factor 2 (SOX2) genes into the MG-63 human OS cell line (MG-OKS). Parental and GFP-transduced MG-63 cells were used as negative control. We assessed the properties of the generated cells in vitro and in vivo. Multiple comparisons among groups were made using a one-way analysis of variance (ANOVA) followed by post hoc testing with Tukey's procedure. RESULTS: MG-OKS cells in vitro exhibited the significantly increased mRNA expression levels of CSC markers (CD24, CD26, and CD133), decreased cell growth, increased chemoresistance and cell migration, and enhanced sphere formation. Notably, MG-OKS cells cultured under osteogenic differentiation conditions showed strongly positive staining for both Alizarin Red S and alkaline phosphatase, indicating osteogenesis of the cells. Gene ontology analysis of microarray data revealed significant upregulation of epidermal-related genes. Tumors derived from MG-OKS cells in vivo were significantly larger than those from other cells in μCT analysis, and immunohistochemical staining showed that Ki-67, osteocalcin, and HIF-1α-positive cells were more frequently detected in the MG-OKS-derived tumors. CONCLUSIONS: In this study, we successfully generated OS CSC-like cells with significantly enhanced CSC properties following transduction of defined factors.

  Oct. 2020, Stem cell research & therapy, 11(1) (1), 429 - 429, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 肩関節拘縮に対する徒手的受動術の成否に関する因子の検討

  美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 篠原 一生, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 172 - 172, Japanese


• 腱細胞における高血糖ストレスに対するQuercetinの抗酸化作用

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 293 - 293, Japanese


• 【骨粗鬆症と骨粗鬆症関連骨折に対する診断と治療】リエゾンサービス 骨粗鬆症リエゾンサービス 多職種連携を中心に

  西本 華子, 新倉 隆宏, 黒田 良祐

  (株)南江堂, Oct. 2020, 別冊整形外科, (78) (78), 217 - 220, Japanese


• 転移性骨腫瘍の治療戦略 脊椎転移手術の術後創離開に関する傾向と対策

  角谷 賢一朗, 張 鐘穎, 由留部 崇, 垣内 裕司, 酒井 良忠, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 15 - 15, Japanese


• 若年者における解剖学的二重束前十字靱帯再建術の臨床成績 一重束再建術との比較

  長井 寛斗, 松下 雄彦, 中西 雄太, 荒木 大輔, 星野 祐一, 神崎 至幸, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2020, 日本臨床スポーツ医学会誌, 28(4) (4), S188 - S188, Japanese


• 前十字靱帯再建術後1年での客観的指標の目標値達成と心理的側面の関連

  上田 雄也, 松下 雄彦, 柴田 洋平, 瀧口 耕平, 長井 寛斗, 荒木 大輔, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2020, 日本臨床スポーツ医学会誌, 28(4) (4), S195 - S195, Japanese


• 前十字靱帯再建術後1年以降の再断裂要因に関する検討

  柴田 洋平, 松下 雄彦, 上田 雄也, 瀧口 耕平, 長井 寛斗, 荒木 大輔, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2020, 日本臨床スポーツ医学会誌, 28(4) (4), S197 - S197, Japanese


• 当科における足関節外側不安定症に対する鏡視下外側靱帯修復術の術後2年での臨床成績

  片岡 君成, 神崎 至幸, 抽冬 晃司, 山本 哲也, 山下 貴大, 長井 寛斗, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2020, 日本臨床スポーツ医学会誌, 28(4) (4), S203 - S203, Japanese


• 距骨骨軟骨損傷を合併した足関節不安定症に対する鏡視下外側靱帯修復術後の臨床成績に関する検討

  抽冬 晃司, 神崎 至幸, 片岡 君成, 山本 哲也, 山下 貴大, 長井 寛斗, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2020, 日本臨床スポーツ医学会誌, 28(4) (4), S203 - S203, Japanese


• 両側高度内反型変形性膝関節症に対して両側高位脛骨骨切り術を施行し、サッカー復帰を果たしたサッカー愛好家の一例

  鎌田 紘平, 松下 雄彦, 片岡 君成, 抽冬 晃司, 森 昭嘉, 山本 哲也, 中西 雄太, 長井 寛斗, 荒木 大輔, 神崎 至幸, 星野 祐一, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2020, 日本臨床スポーツ医学会誌, 28(4) (4), S262 - S262, Japanese


• 弾発現象を伴った長母趾屈筋腱の絞扼性腱鞘滑膜炎に対して後足部内視鏡手術で治療した一例

  下薗 涼太, 神崎 至幸, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 213 - 213, Japanese


• 膝前十字靱帯再建術後脛骨骨髄炎に対し抗生剤入りセメント充填術を施行した一例

  田中 惇貴, 荒木 大輔, 松下 雄彦, 星野 祐一, 長井 寛斗, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 220 - 220, Japanese


• Reconstruction of Carpal Bone Loss of Septic Wrist Arthritis Using Induced Membrane Technique.

  Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Takahiro Niikura, Ryosuke Kuroda

  The induced membrane technique has been widely used for the reconstruction of the segmental bone defect. The technique requires two-stage surgery. The first surgery is debridement of the affected bone and replacement of the defect by cement spacer. The spacer is removed at the second surgery, and the defect is filled with cancellous bone. The use of the technique for septic wrist arthritis treatment has not been reported. We report two cases of septic wrist arthritis treated by the induced membrane technique. Radical debridement including the carpal bones was performed as a first surgery. The cement spacer was placed into the bone defect after first surgery; then cancellous bone was transplanted into the induced membrane several weeks later. External fixator or plate fixation was performed simultaneously. Bone formation was observed in both cases at several months after the reconstruction surgery. There was no pain or recurrence of infection in both cases. We consider this technique is a possible method for reconstruction, especially in a difficult case.

  Oct. 2020, Journal of hand and microsurgery, 12(Suppl 1) (Suppl 1), S54-S57, English, International magazine


• 前十字靱帯再建術後1年以降の再断裂要因に関する検討

  柴田 洋平, 松下 雄彦, 上田 雄也, 瀧口 耕平, 長井 寛斗, 荒木 大輔, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2020, 日本臨床スポーツ医学会誌, 28(4) (4), S197 - S197, Japanese


• 前十字靱帯再建術後1年での客観的指標の目標値達成と心理的側面の関連

  上田 雄也, 松下 雄彦, 柴田 洋平, 瀧口 耕平, 長井 寛斗, 荒木 大輔, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2020, 日本臨床スポーツ医学会誌, 28(4) (4), S195 - S195, Japanese


• 上腕骨インプラント周囲骨折後にballooning変形を起こした偽関節の1例

  松宮 豊, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 157 - 157, Japanese


• 弾発現象を伴った長母趾屈筋腱の絞扼性腱鞘滑膜炎に対して後足部内視鏡手術で治療した一例

  下薗 涼太, 神崎 至幸, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 213 - 213, Japanese


• 膝前十字靱帯再建術後脛骨骨髄炎に対し抗生剤入りセメント充填術を施行した一例

  田中 惇貴, 荒木 大輔, 松下 雄彦, 星野 祐一, 長井 寛斗, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 220 - 220, Japanese


• 上腕骨遠位coronal shear fractureの治療成績

  向原 伸太郎, 美舩 泰, 乾 淳幸, 黒田 司, 脇 貴洋, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 112 - 112, Japanese


• 寛骨臼の転移性骨腫瘍に対して骨セメント充填及びスクリューによる内固定を行った2例

  葛原 慎, 河本 旭哉, 竹森 俊幸, 大江 啓介, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 95 - 95, Japanese


• 肩関節拘縮に対する徒手的受動術の成否に関する因子の検討

  美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 篠原 一生, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 172 - 172, Japanese


• 腱細胞における高血糖ストレスに対するQuercetinの抗酸化作用

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 篠原 一生, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2020, 日本肩関節学会抄録集, 47回, 293 - 293, Japanese


• Varus deformity in the proximal tibia and immediate postoperative varus alignment result in varus progression in limb alignment in the long term after total knee arthroplasty.

  Yuichi Kuroda, Koji Takayama, Shinya Hayashi, Shingo Hashimoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: The aim of this study was to examine and evaluate the factors associated with changes in limb alignment 10 years after total knee arthroplasty (TKA). The hypothesis was that bone morphology and immediate postoperative alignment could be correlated with long-term post-operative alignment changes following TKA. METHODS: This study retrospectively analysed 136 consecutive primary TKA cases for varus deformity, performed from 2006 to 2008, that could be followed for at least 10 years postoperatively. Anteroposterior long-leg weight-bearing radiographs were obtained within 1 month and at least 10 years after surgery. The hip-knee-ankle (HKA) angle immediately after surgery was compared with that 10 years later; factors correlating with the change in HKA angle (δHKA) were evaluated. RESULTS: The mean HKA angles were significantly different between immediate and long-term postoperative assessments (0.1° ± 1.9° vs. 1.2° ± 2.9°, p < 0.001). Furthermore, a significant difference was observed in the outlier ratio (> 3° deviation from the 0° of HKA angle) (10% vs. 24%, p = 0.002). δHKA strongly correlated with a higher preoperative tibial plateau tip-to-proximal tibial shaft (TPTPS) angle, higher postoperative HKA angle, lateral distal femoral angle, and lower postoperative medial proximal tibial angle. CONCLUSION: Varus deformity in the proximal part of the tibia, immediate postoperative varus alignment, and varus position of the femoral and tibial components may lead to varus progression in limb alignment in the long term, even 10 years after TKA; the surgeon should, therefore, weigh the risks of leaving a varus alignment during surgery. Moreover, if the preoperative TPTPS angle is high, the alignment may become varus after TKA, even in patients who have acquired neutral alignment. LEVEL OF EVIDENCE: IV.

  Oct. 2020, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 28(10) (10), 3287 - 3293, English, International magazine

  Scientific journal


• Why are patients dissatisfied following a total knee replacement? A systematic review.

  Naoki Nakano, Haitham Shoman, Fernando Olavarria, Tomoyuki Matsumoto, Ryosuke Kuroda, Vikas Khanduja

  BACKGROUND: Although total knee replacement (TKR) is an effective intervention for end-stage arthritis of the knee, a significant number of patients remain dissatisfied following this procedure. Our aim was to identify and assess the factors affecting patient satisfaction following a TKR. MATERIALS AND METHODS: In accordance with the PRISMA guidelines, two reviewers searched the online databases for literature describing factors affecting patient satisfaction following a TKR. The research question and eligibility criteria were established a priori. Any clinical outcome study that described factors relating to overall satisfaction after primary TKR was included. Quality assessment for the included studies was performed by two accredited orthopaedic surgeons experienced in clinical research. RESULTS: The systematic review identified 181 relevant articles in total. A history of mental health problems was the most frequently reported factor affecting patient satisfaction (13 reportings). When the results of the quality assessment were taken into consideration, a negative history of mental health problems, use of a mobile-bearing insert, patellar resurfacing, severe pre-operative radiological degenerative change, negative history of low back pain, no/less post-operative pain, good post-operative physical function and pre-operative expectations being met were considered to be important factors leading to better patient satisfaction following a TKR. CONCLUSION: Surgeons performing a TKR should take these factors into consideration prior to deciding whether a patient is suitable for a TKR. Secondarily, a detailed explanation of these factors should form part of the process of informed consent to achieve better patient satisfaction following TKR. There is a great need for a unified approach to assessing satisfaction following a TKR and also the time at which satisfaction is assessed.

  Oct. 2020, International orthopaedics, 44(10) (10), 1971 - 2007, English, International magazine

  Scientific journal


• Muscle Strains in the Lower Extremity of Japanese Professional Baseball Players.

  Takeshi Kokubu, Yutaka Mifune, Noriyuki Kanzaki, Yuichi Hoshino, Kenichiro Kakutani, Atsuyuki Inui, Shingo Hashimoto, Ryosuke Kuroda

  Background: Predicting when athletes can return to play after muscle strains is not always simple because of difficulties in evaluating the severity of such injuries. Purpose/Hypothesis: The purpose of this study was to evaluate the use of magnetic resonance imaging (MRI) to classify lower extremity muscle strains in Japanese professional baseball players. The hypothesis was that MRI grading can be used to diagnose the severity of muscle strains in the lower extremity and predict return to play in athletes. Study Design: Case series; Level of evidence, 4. Methods: A total of 55 muscle strains occurred in the lower extremity of players on a professional baseball team between the 2006 and 2015 seasons; all players had undergone MRI examination. Age, player position, location of injury, cause of injury, and duration until return to play (in days) were extracted from the medical records. MRI scans were classified using the following system: grade 0, no abnormal findings; grade 1a, T2-weighted high intensity only between muscles; grade 1b, T2-weighted high intensity between muscles and in muscle belly; grade 2, injury of musculotendinous junction; and grade 3, rupture of tendon insertion. Results: The sites of injuries were distributed as follows: hamstrings (n = 33), quadriceps (n = 6), hip adductors (n = 6), and calves (n = 10). MRI findings revealed 9 muscle strains (16%), 19 grade 1a (34%), 19 grade 1b (34%), and 8 grade 2 muscle strains (16%). The length of time until return to training and competition, respectively, was 15 and 26 days for grade 1a injuries, 19 and 36 days for grade 1b injuries, and 55 and 69 days for grade 2 injuries. Conclusion: Players with grade 1 injuries took 4 to 5 weeks to return to play, whereas players with grade 2 injuries took 10 weeks to return. MRI can be useful for diagnosing lower extremity muscle strains and predicting the time to return to play.

  Oct. 2020, Orthopaedic journal of sports medicine, 8(10) (10), 2325967120956569 - 2325967120956569, English, International magazine

  Scientific journal


• Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model.

  Masanori Tsubosaka, Shinsuke Kihara, Shinya Hayashi, Junpei Nagata, Toshie Kuwahara, Masahiro Fujita, Kenichi Kikuchi, Yoshinori Takashima, Tomoyuki Kamenaga, Yuichi Kuroda, Kazuhiro Takeuchi, Koji Fukuda, Koji Takayama, Shingo Hashimoto, Tomoyuki Matsumoto, Takahiro Niikura, Yasuhiko Tabata, Ryosuke Kuroda

  Eicosapentanoic acid (EPA) is an antioxidant and omega-3 polyunsaturated fatty acid that reduces inflammatory cytokine production. Gelatin hydrogel can be used as a carrier of a physiologically active substance that release it gradually for an average of ~3 weeks. Therefore, this study aimed to clarify the effect of EPA-incorporating gelatin hydrogels on osteoarthritis (OA) progression in vivo. Ten-week-old male C57BL/6J mice were randomly divided into six groups (n = 6): Sham, destabilization of the medial meniscus (DMM), Corn: DMM + 2 µL corn oil, EPA injection alone (EPA-I): DMM + 2 µL corn oil + 125 μg/μL EPA, Gel: DMM + gelatin hydrogels, and EPA-G: DMM + 125 μg/μL EPA-incorporating gelatin hydrogels. The mice were euthanized at 8 weeks after DMM or Sham surgery, and subjected to histological evaluation. Matrix-metalloproteinases-3 (MMP-3), MMP-13, interleukin-1β (IL-1β), p-IKK α/β, CD86, and CD163 protein expression in the synovial cartilage was detected by immunohistochemical staining. F4/80 expression was also assessed using the F4/80 score of macrophage. Histological score was significantly lower in EPA-G than in EPA-I. MMP-3-, MMP-13-, IL-1β-, and p-IKK α/β-positive cell ratio was significantly lower in EPA-G than in EPA-I. However, CD86- and CD163-positive cell ratio was not significantly different between EPA-I and EPA-G. The average-sum F4/80 score of macrophage in EPA-G was significantly lower than that in EPA-I. EPA-incorporating gelatin hydrogels were shown to prevent OA progression in vivo more effectively than EPA injection alone. Our results suggested that intra-articular administration of controlled-release EPA can be a new therapeutic approach for treating OA.

  Oct. 2020, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 38(10) (10), 2157 - 2169, English, International magazine

  [Refereed]

  Scientific journal


• Bilateral Collateral Ligament Reconstruction for Chronic Elbow Dislocation.

  Takeshi Kataoka, Takeshi Kokubu, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Shintaro Mukohara, Ryosuke Kuroda

  We report the case of a 37-year-old male with autism spectrum disorder who was hospitalized for chronic elbow dislocation. He had suffered a posterior elbow dislocation 5 months ago. His elbow dislocation was easily reduced, but the reduction position could not be maintained. Severe varus and valgus instabilities were observed in his right elbow. He was diagnosed with chronic elbow dislocation due to bilateral collateral ligament dysfunction and was surgically treated. Bilateral ligament reconstruction using the bilateral palmaris longus (PL) tendon combined with a temporary ulnohumeral joint fixation was performed. Cast immobilization was applied for 6 weeks. One year after surgery, his range of motion was -15° in extension, 140° in flexion, 80° in pronation, and 90° in supination. He did not face any problems in daily activities.

  Sep. 2020, The Kobe journal of medical sciences, 66(2) (2), E71-E74, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Intraoperative posterior movement of the tibia at 90° of flexion predicts worse postoperative flexion angles in cruciate-substituting total knee arthroplasty.

  Takao Inokuchi, Kazunari Ishida, Koji Takayama, Nao Shibanuma, Shinya Hayashi, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: To investigate the correlation between intraoperative tibiofemoral anteroposterior changes at 90° of flexion and postoperative maximum flexion angles in navigated cruciate-substituting TKA. The hypothesis of this study was that intraoperative tibiofemoral anteroposterior changes at 90° of flexion indirectly reflect posterior cruciate ligament (PCL) function and associate with postoperative maximum flexion angles. METHODS: Fifty-five consecutive patients with varus osteoarthritis treated with primary TKA were retrospectively analysed. All patients received the same type of implant, placed with an image-free navigation system. The PCL was retained, and cruciate-substituting inserts were used in all cases. The mean follow-up was 44 ± 8 months. The preoperative and postoperative kinematics were measured intraoperatively with a navigation system, and the preoperative and postoperative tibiofemoral anteroposterior positions at 90° of flexion were determined. The correlation between intraoperative anteroposterior position changes and postoperative maximum flexion angles was investigated. The correlation between the change of anteroposterior position and tibiofemoral rotational angles was also assessed. RESULTS: The intraoperative anteroposterior position change was -1.7 ± 3.4 mm (a positive value indicates tibial posterior shift). Flexion angle improvement was negatively correlated with intraoperative change of tibiofemoral anteroposterior position (R2 = 0.17, p < 0.005). Postoperative maximum flexion angles were also negatively correlated with intraoperative change of tibiofemoral anteroposterior position (R2 = 0.09, p < 0.05). The postoperative amount of tibial internal rotation was positively correlated with the preoperative amount (R2 = 0.60, p < 0.0001); however, the intraoperative anteroposterior position change was not correlated with the postoperative amount of tibial internal rotation (n.s.). CONCLUSION: A navigation system may be able to indirectly evaluate PCL function and predict the postoperative flexion angles in cruciate-substituting TKA. Intraoperative posterior movement of the tibia at 90° of flexion predicts worse postoperative flexion angles in cruciate-substituting TKA. LEVEL OF EVIDENCE: Level 3, retrospective comparative study.

  Sep. 2020, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 28(9) (9), 2816 - 2822, English, International magazine

  [Refereed]

  Scientific journal


• Improved implant alignment accuracy with an accelerometer-based portable navigation system in medial unicompartmental knee arthroplasty.

  Yoshihito Suda, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Shingo Hashimoto, Takahiro Niikura, Takehiko Matsushita, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: This study aimed to examine the accuracy of tibial implant alignment using an accelerometer-based portable navigation system in unicompartmental knee arthroplasty (UKA). METHODS: This retrospective matched case-control study reviewed 51 UKAs performed using an accelerometer-based portable navigation system, matched with 51 UKAs performed using conventional extramedullary rods. Coronal alignment and posterior slope of the tibial implant were measured on postoperative radiographs, and differences from preoperative planning were examined. Outliers and accuracy of tibial implant alignment were compared between the portable navigation and conventional groups using Fisher's exact test and Mann-Whitney U test, respectively. RESULTS: In the portable navigation group, 100% of the implants were aligned within 3.0° of both target coronal and sagittal implant alignment. In the conventional group, 76.5% and 88.2% of the implants were within 3.0° of both target coronal and sagittal implant alignment. Statistical analysis revealed that outliers of coronal and sagittal alignment were significantly less in the portable navigation group than in the conventional group (P < 0.05). In addition, the absolute value difference between postoperative measurement and preoperative planning of both coronal and sagittal alignment was significantly smaller in the portable navigation group than in the conventional group (P < 0.05). CONCLUSION: The portable navigation system improved the accuracy of tibial implant alignment in UKA. We found that 100% of the implants were aligned within 3.0° of both target coronal and sagittal implant alignment. The portable navigation system decreased the outliers of tibial coronal and sagittal alignment. LEVEL OF EVIDENCE: Retrospective case-control study, Level III.

  Sep. 2020, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 28(9) (9), 2917 - 2923, English, International magazine

  [Refereed]

  Scientific journal


• Effects of the duration of transcutaneous CO2 application on the facilitatory effect in rat fracture repair.

  Takahiro Oda, Takashi Iwakura, Tomoaki Fukui, Keisuke Oe, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Teruya Kawamoto, Yoshitada Sakai, Toshihiro Akisue, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Carbon dioxide therapy has been reported to be effective in treating certain cardiac diseases and skin problems. Although a previous study suggested that transcutaneous carbon dioxide application accelerated fracture repair in association with promotion of angiogenesis, blood flow, and endochondral ossification, the influence of the duration of carbon dioxide application on fracture repair is unknown. The aim of this study was to investigate the effect of the duration of transcutaneous carbon dioxide application on rat fracture repair. METHODS: A closed femoral shaft fracture was created in each rat. Animals were randomly divided into four groups: the control group; 1w-CO2 group, postoperative carbon dioxide treatment for 1 week; 2w-CO2 group, postoperative carbon dioxide treatment for 2 weeks; 3w-CO2 group, postoperative carbon dioxide treatment for 3 weeks. Transcutaneous carbon dioxide application was performed five times a week in the carbon dioxide groups. Sham treatment, where the carbon dioxide was replaced with air, was performed for the control group. Radiographic, histological, and biomechanical assessments were performed at 3 weeks after fracture. RESULTS: The fracture union rate was significantly higher in the 3w-CO2 group than in the control group (p < 0.05). Histological assessment revealed promotion of endochondral ossification in the 3w-CO2 group than in the control group. In the biomechanical assessment, all evaluation items related to bone strength were significantly higher in the 3w-CO2 group than in the control group (p < 0.05). CONCLUSIONS: The present study, conducted using an animal model, demonstrated that continuous carbon dioxide application throughout the process of fracture repair was effective in enhancing fracture healing.

  Sep. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(5) (5), 886 - 891, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 高位脛骨骨切り術における術後立位・臥位での下肢アライメントの検討

  渡邉 秀, 松下 雄彦, 長井 寛斗, 荒木 大輔, 星野 祐一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2020, 中部日本整形外科災害外科学会雑誌, 63(5) (5), 829 - 830, Japanese


• 半月板温存療法の最先端 半月板切除後の自然経過

  松下 雄彦, 中西 雄太, 長井 寛斗, 星野 祐一, 荒木 大輔, 神崎 至幸, 黒田 良祐

  (一社)日本関節病学会, Sep. 2020, 日本関節病学会誌, 39(3) (3), 253 - 253, Japanese


• 骨粗鬆症外来受診患者にたいする機械学習による骨密度予測

  乾 淳幸, 西本 華子, 美舩 泰, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2020, 日本骨粗鬆症学会雑誌, 6(Suppl.1) (Suppl.1), 244 - 244, Japanese


• Trabecular Bone Score(TBS)は治療の効果判定に有用か

  西本 華子, 乾 淳幸, 美舩 泰, 新倉 隆宏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2020, 日本骨粗鬆症学会雑誌, 6(Suppl.1) (Suppl.1), 254 - 254, Japanese


• 卵巣摘出ラット骨粗鬆症モデルにおける炭酸ガス経皮吸収による骨粗鬆症改善効果の検討

  澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 吉川 遼, 小田 崇弘, 隈部 洋平, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1684 - S1684, Japanese


• Reamer irrigator aspirator(RIA)産物から得た細胞の骨分化に対するlow-intensity pulsed ultrasound(LIPUS)の効果

  澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 吉川 遼, 小田 崇弘, 隈部 洋平, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1685 - S1685, Japanese


• ウサギを用いた222nm紫外線術野照射の安全性の検討

  福井 友章, 新倉 隆宏, 小田 崇弘, 隈部 洋平, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1713 - S1713, Japanese


• 炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおける骨折治癒を促進させる

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 隈部 洋平, 澤内 健一, 吉川 遼, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1802 - S1802, Japanese


• 骨折治癒過程を超音波の周波数特性により推定する試み

  大江 啓介, 隈部 洋平, 新倉 隆宏, 福井 友章, 黒田 良祐, 畑 豊, 森本 雅和, 八木 直美, 小矢 美晴

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1918 - S1918, Japanese


• 男性骨粗鬆症モデルラットに対する炭酸ガス経皮吸収の影響に関する検討

  吉川 遼, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 小田 崇弘, 隈部 洋平, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1956 - S1956, Japanese


• 不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する

  平田 悠, 野村 和弘, 新倉 隆宏, 橘 吉寿, 加藤 大輔, 内山 奏, 福井 友章, 大江 啓介, 細岡 哲也, 和氣 弘明, 黒田 良祐, 小川 渉

  (一社)日本抗加齢医学会, Sep. 2020, 日本抗加齢医学会総会プログラム・抄録集, 20回, 181 - 181, Japanese


• 糖尿病性腱障害モデルに対するアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1680 - S1680, Japanese


• 老化制御因子NMN(nicotinamide mononucleotide)の腱炎に対する抗炎症・酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1746 - S1746, Japanese


• 高血糖誘導酸化ストレスを与えた腱細胞に対するDHEAの効果

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1747 - S1747, Japanese


• 高血糖負荷による酸化ストレスを与えた腱細胞に対するquercetinの抗酸化作用の検討

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1758 - S1758, Japanese


• ウェアラブルセンサで測定した投球肘ストレスと超音波剪断波エラストグラフィで評価した前腕回内屈筋の組織弾性との相関

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1899 - S1899, Japanese


• 三次元電磁気センサを使用した遠位橈尺関節不安定性の定量評価法

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 吉川 智也, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1903 - S1903, Japanese


• ラット腱板修復モデルにおけるティラピア由来うろこコラーゲンの有効性の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1927 - S1927, Japanese


• 骨粗鬆症外来受診患者にたいする機械学習による骨密度予測

  乾 淳幸, 西本 華子, 美舩 泰, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2020, 日本骨粗鬆症学会雑誌, 6(Suppl.1) (Suppl.1), 244 - 244, Japanese


• Trabecular Bone Score(TBS)は治療の効果判定に有用か

  西本 華子, 乾 淳幸, 美舩 泰, 新倉 隆宏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2020, 日本骨粗鬆症学会雑誌, 6(Suppl.1) (Suppl.1), 254 - 254, Japanese


• 早期離床・リハビリテーション加算新設に伴う変化について

  松本 健, 原田 理沙, 大西 宏和, 今村 愛生, 吉川 遼, 江木 盛時, 溝渕 知司, 黒田 良祐, 酒井 良忠

  (一社)日本集中治療医学会, Sep. 2020, 日本集中治療医学会雑誌, 27(Suppl.) (Suppl.), 517 - 517, Japanese


• 【外来でよく診る膝疾患】内側半月板変性断裂に対する診療

  松下 雄彦, 黒田 良祐

  (株)全日本病院出版会, Sep. 2020, Orthopaedics, 33(9) (9), 17 - 24, Japanese


• マウスにおける非培養ヒト脂肪組織由来再生細胞の移植による変形性膝関節症の進行の抑制

  山下 貴大, 松下 雄彦, 松本 知之, 岩畔 英樹, 傍島 聰, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1962 - S1962, Japanese


• ACL損傷膝に合併する半月板損傷が膝不安定性に与える影響の定量評価による検討

  森 昭嘉, 星野 祐一, 抽冬 晃司, 渡邊 秀, 中西 雄太, 山本 哲也, 長井 寛斗, 荒木 大輔, 神崎 至幸, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1925 - S1925, Japanese


• 魚鱗由来高強度コラーゲンフィブリル線維による膝靱帯修復促進効果の検討

  寛島 佑史, 松下 雄彦, 長井 寛斗, 荒木 大輔, 神崎 至幸, 星野 祐一, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1929 - S1929, Japanese


• 膝前十字靱帯解剖学的二重束再建術での脛骨骨孔重複のリスク因子についての検討

  抽冬 晃司, 星野 祐一, 中西 雄太, 山本 哲也, 長井 寛斗, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S2026 - S2026, Japanese


• 高位脛骨骨切り術における術後立位・臥位での下肢アライメントの検討

  渡邉 秀, 松下 雄彦, 長井 寛斗, 荒木 大輔, 星野 祐一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2020, 中部日本整形外科災害外科学会雑誌, 63(5) (5), 829 - 830, Japanese


• 下肢難治性骨折に対する細胞治療

  黒田 良祐, 新倉 隆宏, 福井 友章, 大江 啓介, 松本 知之

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S36 - S36, Japanese


• 骨折に対する積極的保存療法(臨床編)第1部 LIPUS照射部位ターゲティング

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S40 - S40, Japanese


• 骨転移症例に対する骨折治療戦略 骨修飾薬使用中の癌骨転移患者に発生した非定型大腿骨骨折についての多施設共同研究

  福井 友章, 新倉 隆宏, 大江 啓介, 高原 俊介, 櫻井 敦志, 岩倉 崇, 吉田 圭二, 伊藤 研二郎, 正田 悦朗, 北田 真平, 平中 崇文, 角田 雅也, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S70 - S70, Japanese


• Masquelet法におけるinduced membraneのMRI評価についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S121 - S121, Japanese


• Masquelet法におけるinduced membraneの患者検体を用いた組織学的検討

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S121 - S121, Japanese


• Masquelet法におけるinduced membraneはpseudo-synovial membraneか?

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S122 - S122, Japanese


• 大腿骨転子部骨折におけるshort femoral nailの髄内挙動 模擬骨を用いた力学試験

  高原 俊介, 長宗 高樹, 大江 啓介, 野田 光昭, 市村 克仁, 西原 寛玄, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S129 - S129, Japanese


• 1型糖尿病ラット骨折モデルにおける炭酸ガス経皮吸収による骨折治癒促進効果の検討

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 吉川 遼, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S146 - S146, Japanese


• 偽関節における骨SPECTを用いた定量評価の試み

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S366 - S366, Japanese


• 卵巣摘出ラット骨粗鬆症モデルにおける炭酸ガス経皮吸収による骨粗鬆症改善効果の検討

  澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 吉川 遼, 小田 崇弘, 隈部 洋平, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1684 - S1684, Japanese


• Reamer irrigator aspirator(RIA)産物から得た細胞の骨分化に対するlow-intensity pulsed ultrasound(LIPUS)の効果

  澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 吉川 遼, 小田 崇弘, 隈部 洋平, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1685 - S1685, Japanese


• ウサギを用いた222nm紫外線術野照射の安全性の検討

  福井 友章, 新倉 隆宏, 小田 崇弘, 隈部 洋平, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1713 - S1713, Japanese


• 炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおける骨折治癒を促進させる

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 隈部 洋平, 澤内 健一, 吉川 遼, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1802 - S1802, Japanese


• 骨折治癒過程を超音波の周波数特性により推定する試み

  大江 啓介, 隈部 洋平, 新倉 隆宏, 福井 友章, 黒田 良祐, 畑 豊, 森本 雅和, 八木 直美, 小矢 美晴

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1918 - S1918, Japanese


• 男性骨粗鬆症モデルラットに対する炭酸ガス経皮吸収の影響に関する検討

  吉川 遼, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 小田 崇弘, 隈部 洋平, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1956 - S1956, Japanese


• Ewing肉腫におけるcellular dormancyの同定とその特性の探索

  八尋 俊輔, 河本 旭哉, 川上 洋平, 原 仁美, 竹森 俊幸, 藤原 周一, 北山 和道, 宮本 智弘, 青井 貴之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1856 - S1856, Japanese


• 乳癌骨転移における骨破壊に寄与するmiRNAの探索

  北山 和道, 河本 旭哉, 原 仁美, 深瀬 直政, 川上 洋平, 竹森 俊幸, 藤原 周一, 八尋 俊輔, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1861 - S1861, Japanese


• 遺伝子導入による人工骨肉腫幹細胞株の樹立

  藤原 周一, 河本 旭哉, 川上 洋平, 原 仁美, 竹森 俊幸, 北山 和道, 八尋 俊輔, 宮本 智弘, 青井 貴之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1982 - S1982, Japanese


• 糖尿病性腱障害モデルに対するアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1680 - S1680, Japanese


• 老化制御因子NMN(nicotinamide mononucleotide)の腱炎に対する抗炎症・酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1746 - S1746, Japanese


• 高血糖誘導酸化ストレスを与えた腱細胞に対するDHEAの効果

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1747 - S1747, Japanese


• 高血糖負荷による酸化ストレスを与えた腱細胞に対するquercetinの抗酸化作用の検討

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1758 - S1758, Japanese


• ウェアラブルセンサで測定した投球肘ストレスと超音波剪断波エラストグラフィで評価した前腕回内屈筋の組織弾性との相関

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1899 - S1899, Japanese


• 三次元電磁気センサを使用した遠位橈尺関節不安定性の定量評価法

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 吉川 智也, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1903 - S1903, Japanese


• ラット腱板修復モデルにおけるティラピア由来うろこコラーゲンの有効性の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1927 - S1927, Japanese


• ACL損傷膝に合併する半月板損傷が膝不安定性に与える影響の定量評価による検討

  森 昭嘉, 星野 祐一, 抽冬 晃司, 渡邊 秀, 中西 雄太, 山本 哲也, 長井 寛斗, 荒木 大輔, 神崎 至幸, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1925 - S1925, Japanese


• 魚鱗由来高強度コラーゲンフィブリル線維による膝靱帯修復促進効果の検討

  寛島 佑史, 松下 雄彦, 長井 寛斗, 荒木 大輔, 神崎 至幸, 星野 祐一, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1929 - S1929, Japanese


• 膝前十字靱帯解剖学的二重束再建術での脛骨骨孔重複のリスク因子についての検討

  抽冬 晃司, 星野 祐一, 中西 雄太, 山本 哲也, 長井 寛斗, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S2026 - S2026, Japanese


• Larger Acetabular Labrum Is Associated With Hip Dysplasia, Joint Incongruence, and Clinical Symptoms.

  Tomoyuki Kamenaga, Shingo Hashimoto, Shinya Hayashi, Koji Takayama, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: To evaluate the association of labral length with acetabular morphology and clinical symptoms. METHODS: Patients treated at our hip joint clinic between January 2015 and December 2018 were retrospectively enrolled in the study. Our sample included patients who received a diagnosis of one or more of the following: hip labral tear, femoroacetabular impingement (FAI), and developmental dysplasia of the hip. Patients with osteoarthritis and/or osteonecrosis were excluded. Bilateral labral length was measured as the distance from the acetabular rim to the edge of the labrum at the level of the central coronal T1-weighted magnetic resonance imaging scan cross-referenced to the axial plane (3- to 9-o'clock position). The lateral center-edge angle (LCEA) and acetabular roof obliquity (ARO) were evaluated with plain radiographs. An LCEA of 25° or less was defined as developmental dysplasia of the hip, whereas a positive crossover sign in the presence of an LCEA of 30° or greater, an LCEA greater than 40°, or acetabular inclination lower 0° was defined as pincer FAI. An alpha angle greater than 50° or head-neck offset lower 8 mm was considered cam FAI. The severity of hip symptoms was evaluated bilaterally using the Japanese Orthopaedic Association pain scale, on which hips scoring full points (i.e., a perfect score) were defined as asymptomatic whereas hips with all other scores were considered symptomatic. We used simple linear regression to examine the correlations of labral length with the LCEA and ARO. Labral length was also compared according to patient hip symptom status using the Mann-Whitney U test. RESULTS: The study included 102 patients (14 with bilateral symptoms and 88 with unilateral symptoms). Labral length was strongly correlated with the LCEA (r = -0.612, P < .001) and ARO (r = 0.635, P < .001). Additionally, patients with symptomatic hips had significantly larger labra (9.5 ± 3.0 mm) than those with asymptomatic hips (7.9 ± 2.1 mm, P = .004). CONCLUSIONS: Acetabular labral length is significantly greater in dysplastic, irregularly congruent, symptomatic hips. LEVEL OF EVIDENCE: Level Ⅳ, retrospective cross-sectional study.

  Sep. 2020, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 36(9) (9), 2446 - 2453, English, International magazine

  Scientific journal


• Infected Gustilo IIIB open knee joint fracture treated with an antimicrobial iodine-supported megaprosthesis: A case report.

  Shin Osawa, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Hiroyuki Tsuchiya, Takahiro Niikura

  Aug. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 28(2) (2), 495 - 498, English, Domestic magazine

  Link to Kobe Univ. Repository (Kernel)


• Preoperative anterior coverage of the medial acetabulum can predict postoperative anterior coverage and range of motion after periacetabular osteotomy: a cohort study.

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Tomoyuki Kamenaga, Takahiro Niikura, Ryosuke Kuroda

  BACKGROUND: We hypothesized that preoperative pelvic morphology may affect postoperative anterior coverage and postoperative clinical range of motion (ROM) leading to postoperative pincer type femoroacetabular impingement (FAI). The aim of this study was to evaluate the relationships between preoperative bone morphology and postoperative ROMs to prevent postoperative FAI after periacetabular osteotomy. METHODS: Sixty-eight patients (71 hips) with hip dysplasia participated in this study and underwent curved PAO. The acetabular fragment was usually moved only by lateral rotation of the acetabulum, without intraoperative anterior or posterior rotation. The pre- and postoperative three-dimensional center-edge (CE) angles were measured and compared to the postoperative ROM. RESULTS: Preoperative medial anterior CE angle was significantly associated with postoperative anterior CE angle, and the correlation coefficient of medial anterior CE and postoperative anterior CE was higher than the coefficient of preoperative anterior CE and postoperative anterior CE (preoperative anterior CE, rr = 0.27, p = 0.020; preoperative medial anterior CE, rr = 0.54, p < 0.001). Femoral anteversion correlated with postoperative internal rotation angle at 90° flexion (r = 0.32, p = 0.021). In multiple linear regressions, postoperative internal rotation angle at 90° flexion angle was significantly affected by both medial CE angle through the medial one fourth of femoral head and femoral anteversion. CONCLUSIONS: Preoperative medial anterior acetabular coverage was associated with postoperative anterior acetabular coverage. Further, the combination with preoperative medial anterior acetabular coverage and femoral anteversion can predict postoperative internal rotation at 90° flexion. Therefore, the direction of acetabular reorientation should be carefully considered when the patients have high preoperative medial anterior CE angle and small femoral anteversion.

  Aug. 2020, Journal of orthopaedic surgery and research, 15(1) (1), 312 - 312, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Intraoperative Soft Tissue Balance/Kinematics and Clinical Evaluation of Modified Kinematically versus Mechanically Aligned Total Knee Arthroplasty.

  Tomoyuki Matsumoto, Koji Takayama, Kazunari Ishida, Yuichi Kuroda, Masanori Tsubosaka, Hirotsugu Muratsu, Shinya Hayashi, Shingo Hashimoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda

  Recently, kinematically aligned total knee arthroplasty has been found to achieve better clinical outcomes than mechanically aligned TKA. Despite the good clinical outcomes that are reported at short- to mid-term follow-up, intraoperative variables that are associated with a better outcome have not been measured. Therefore, this study was conducted to compare intraoperative kinematics/soft tissue balance and the clinical outcomes of patients who underwent modified kinematically (restricted tibial cut) or mechanically aligned total knee arthroplasty. Sixty cruciate-retaining total knee arthroplasties (30 modified kinematically [3-degree varus and 7-degree posterior slope in tibial cut] and 30 mechanically aligned) were performed in patients with varus-type osteoarthritis using a navigation system. Intraoperative kinematics assessed by the navigation system and soft tissue balance assessed by an offset-type tensor were compared between the groups. One year postoperatively, the range of motion and 2011 Knee Society scores were compared between the groups. Kinematic assessment exhibited that tibial internal rotation during flexion was significantly maintained in the kinematic compared with the mechanical group (p < 0.05). Varus/valgus ligament balance at 90 and 120 degrees of flexion significantly maintained lateral laxity in the kinematic compared with the mechanical group (p < 0.05). Improvement of flexion angles, functional activity scores, and patient satisfaction were significantly better in the kinematic than in the mechanical group (p < 0.05). Modified kinematically aligned cruciate-retaining total knee arthroplasty maintained more tibial internal rotation and lateral laxity during flexion than mechanically aligned total knee arthroplasty; thus, the former may result in better clinical outcomes.

  Aug. 2020, The journal of knee surgery, 33(8) (8), 777 - 784, English, International magazine

  [Refereed]

  Scientific journal


• 不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する

  平田 悠, 野村 和弘, 新倉 隆宏, 橘 吉寿, 加藤 大輔, 内山 奏, 福井 友章, 大江 啓介, 細岡 哲也, 和氣 弘明, 黒田 良祐, 小川 渉

  (一社)日本糖尿病学会, Aug. 2020, 糖尿病, 63(Suppl.1) (Suppl.1), S - 238, Japanese


• Percutaneous CO2Treatment Accelerates Bone Generation during Distraction Osteogenesis in Rabbits

  Yohei Kumabe, Tomoaki Fukui, Shunsuke Takahara, Yu Kuroiwa, Michio Arakura, Keisuke Oe, Takahiro Oda, Kenichi Sawauchi, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  Aug. 2020, Clinical Orthopaedics and Related Research, 478(8) (8), 1922 - 1935

  Scientific journal


• Overcorrection of the acetabular roof angle or anterior center-edge angle may cause decrease of range of motion after curved periacetabular osteotomy.

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Tomoyuki Kamenaga, Takahiro Niikura, Ryosuke Kuroda

  The aim of this study was to evaluate the relationship between the correction of radiographic parameters and clinical range of motion (ROM) after periacetabular osteotomy (PAO). Sixty-nine patients with hip dysplasia were enrolled and underwent curved PAO. The pre- and post-operative 3D center-edge (CE) angles, total anteversion (acetabular and femoral anteversion), and radiographic acetabular roof angle were measured and compared with the post-operative ROM. The aim of surgery was to rotate the central acetabular fragment laterally without anterior or posterior rotation. Multiple linear regression analysis demonstrated that post-operative internal rotation at 90° flexion was significantly associated with the post-operative Tönnis sourcil angle (rr = 0.31, P = 0.02) and that the post-operative ROM of flexion and internal rotation at 90° flexion were significantly associated with the anterior CE (flex; rr = -0.44, P = 0.001, internal rotation at 90° flexion; rr = -0.44, P < 0.001). However, we found no association between the lateral CE, femoral anteversion, or total anteversion and the post-operative ROM. We demonstrated that the overcorrection of the acetabular roof angle or anterior CE angle may cause a decrease in the range of motion after curved PAO. Therefore, surgeons need to be careful during surgery to prevent the overcorrection of the weight-bearing area and anterior acetabular coverage of the acetabular fragment to avoid femoroacetabular impingement after PAO.

  Aug. 2020, Journal of hip preservation surgery, 7(3) (3), 583 - 590, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• がんロコモ 緩和ケアとがんロコモ

  原 仁美, 酒井 良忠, 河本 旭哉, 竹森 俊幸, 秋末 敏宏, 黒田 良祐

  (NPO)日本緩和医療学会, Aug. 2020, Palliative Care Research, 15(Suppl.) (Suppl.), S71 - S71, Japanese


• 不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する

  平田 悠, 野村 和弘, 新倉 隆宏, 橘 吉寿, 加藤 大輔, 内山 奏, 福井 友章, 大江 啓介, 細岡 哲也, 和氣 弘明, 黒田 良祐, 小川 渉

  (一社)日本内分泌学会, Aug. 2020, 日本内分泌学会雑誌, 96(1) (1), 248 - 248, Japanese


• 骨転移疼痛に対する集学的治療 -この痛みをどう治療するか- 転移性骨腫瘍に対する外科的治療

  原 仁美, 角谷 賢一朗, 酒井 良忠, 河本 旭哉, 竹森 俊幸, 秋末 敏宏, 黒田 良祐

  (一社)日本インターベンショナルラジオロジー学会, Aug. 2020, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 130 - 130, Japanese


• 骨転移疼痛に対する集学的治療 -この痛みをどう治療するか- 転移性骨腫瘍に対する外科的治療

  原 仁美, 角谷 賢一朗, 酒井 良忠, 河本 旭哉, 竹森 俊幸, 秋末 敏宏, 黒田 良祐

  (一社)日本インターベンショナルラジオロジー学会, Aug. 2020, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 130 - 130, Japanese


• Percutaneous CO2 Treatment Accelerates Bone Generation During Distraction Osteogenesis in Rabbits.

  Yohei Kumabe, Tomoaki Fukui, Shunsuke Takahara, Yu Kuroiwa, Michio Arakura, Keisuke Oe, Takahiro Oda, Kenichi Sawauchi, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Distraction osteogenesis has been broadly used to treat various structural bone deformities and defects. However, prolonged healing time remains a major problem. Various approaches including the use of low-intensity pulsed ultrasound, parathyroid hormone, and bone morphogenetic proteins (BMPs) have been studied to shorten the treatment period with limited success. Our previous studies of rats have reported that the transcutaneous application of CO2 accelerates fracture repair and bone-defect healing in rats by promoting angiogenesis, blood flow, and endochondral ossification. This therapy may also accelerate bone generation during distraction osteogenesis, but, to our knowledge, no study investigating CO2 therapy on distraction osteogenesis has been reported. QUESTIONS/PURPOSES: We aimed to investigate the effect of transcutaneous CO2 during distraction osteogenesis in rabbits, which are the most suitable animal as a distraction osteogenesis model for a lengthener in terms of limb size. We asked: Does transcutaneous CO2 during distraction osteogenesis alter (1) radiographic bone density in the distraction gap during healing; (2) callus parameters, including callus bone mineral content, volumetric bone mineral density, and bone volume fraction; (3) the newly formed bone area, cartilage area, and angiogenesis, as well as the expression of interleukin-6 (IL-6), BMP-2, BMP-7, hypoxia-inducible factor (HIF) -1α, and vascular endothelial growth factor (VEGF); and (4) three-point bend biomechanical strength, stiffness, and energy? METHODS: Forty 24-week-old female New Zealand white rabbits were used according to a research protocol approved by our institutional ethical committee. A distraction osteogenesis rabbit tibia model was created as previously described. Briefly, an external lengthener was applied to the right tibia, and a transverse osteotomy was performed at the mid-shaft. The osteotomy stumps were connected by adjusting the fixator to make no gap. After a 7-day latency phase, distraction was continued at 1 mm per day for 10 days. Beginning the day after the osteotomy, a 20-minute transcutaneous application of CO2 on the operated leg using a CO2 absorption-enhancing hydrogel was performed five times per week in the CO2 group (n = 20). Sham treatment with air was administered in the control group (n = 20). Animals were euthanized immediately after the distraction period (n = 10), 2 weeks (n = 10), and 4 weeks (n = 20) after completion of distraction. We performed bone density quantification on the plain radiographs to evaluate consolidation in the distraction gap with image analyzing software. Callus parameters were measured with micro-CT to assess callus microstructure. The newly formed bone area and cartilage area were measured histologically with safranin O/fast green staining to assess the progress of ossification. We also performed immunohistochemical staining of endothelial cells with fluorescein-labeled isolectin B4 and examined capillary density to evaluate angiogenesis. Gene expressions in newly generated callus were analyzed by real-time polymerase chain reaction. Biomechanical strength, stiffness, and energy were determined from a three-point bend test to assess the mechanical strength of the callus. RESULTS: Radiographs showed higher pixel values in the distracted area in the CO2 group than the control group at Week 4 of the consolidation phase (0.98 ± 0.11 [95% confidence interval 0.89 to 1.06] versus 1.19 ± 0.23 [95% CI 1.05 to 1.34]; p = 0.013). Micro-CT demonstrated that bone volume fraction in the CO2 group was higher than that in the control group at Week 4 (5.56 ± 3.21 % [95% CI 4.32 to 6.12 %] versus 11.90 ± 3.33 % [95% CI 9.63 to 14.25 %]; p = 0.035). There were no differences in any other parameters (that is, callus bone mineral content at Weeks 2 and 4; volumetric bone mineral density at Weeks 2 and 4; bone volume fraction at Week 2). At Week 2, rabbits in the CO2 group had a larger cartilage area compared with those in the control group (2.09 ± 1.34 mm [95% CI 1.26 to 2.92 mm] versus 5.10 ± 3.91 mm [95% CI 2.68 to 7.52 mm]; p = 0.011). More newly formed bone was observed in the CO2 group than the control group at Week 4 (68.31 ± 16.32 mm [95% CI 58.19 to 78.44 mm] versus 96.26 ± 19.37 mm [95% CI 84.25 to 108.26 mm]; p < 0.001). There were no differences in any other parameters (cartilage area at Weeks 0 and 4; newly formed bone area at Weeks 0 and 2). Immunohistochemical isolectin B4 staining showed greater capillary densities in rabbits in the CO2 group than the control group in the distraction area at Week 0 and surrounding tissue at Weeks 0 and 2 (distraction area at Week 0, 286.54 ± 61.55 /mm [95% CI 232.58 to 340.49] versus 410.24 ± 55.29 /mm [95% CI 361.78 to 458.71]; p < 0.001; surrounding tissue at Week 0 395.09 ± 68.16/mm [95% CI 335.34 to 454.83] versus 589.75 ± 174.42/mm [95% CI 436.86 to 742.64]; p = 0.003; at Week 2 271.22 ± 169.42 /mm [95% CI 122.71 to 419.73] versus 508.46 ± 49.06/mm [95% CI 465.45 to 551.47]; p < 0.001 respectively). There was no difference in the distraction area at Week 2. The expressions of BMP -2 at Week 2, HIF1-α at Week 2 and VEGF at Week 0 and 2 were greater in the CO2 group than in the control group (BMP -2 at Week 2 3.84 ± 0.83 fold [95% CI 3.11 to 4.58] versus 7.32 ± 1.63 fold [95% CI 5.88 to 8.75]; p < 0.001; HIF1-α at Week 2, 10.49 ± 2.93 fold [95% CI 7.91 to 13.06] versus 20.74 ± 11.01 fold [95% CI 11.09 to 30.40]; p < 0.001; VEGF at Week 0 4.80 ± 1.56 fold [95% CI 3.43 to 6.18] versus 11.36 ± 4.82 fold [95% CI 7.13 to 15.59]; p < 0.001; at Week 2 31.52 ± 8.26 fold [95% CI 24.27 to 38.76] versus 51.05 ± 15.52 fold [95% CI 37.44 to 64.66]; p = 0.034, respectively). There were no differences in any other parameters (BMP-2 at Week 0 and 4; BMP -7 at Weeks 0, 2 and 4; HIF-1α at Weeks 0 and 4; IL-6 at Weeks 0, 2 and 4; VEGF at Week 4). In the biomechanical assessment, ultimate stress and failure energy were greater in the CO2 group than in the control group at Week 4 (ultimate stress 259.96 ± 74.33 N [95% CI 167.66 to 352.25] versus 422.45 ± 99.32 N [95% CI 299.13 to 545.77]; p < 0.001, failure energy 311.32 ± 99.01 Nmm [95% CI 188.37 to 434.25] versus 954.97 ± 484.39 Nmm [95% CI 353.51 to 1556.42]; p = 0.003, respectively). There was no difference in stiffness (216.77 ± 143.39 N/mm [95% CI 38.73 to 394.81] versus 223.68 ± 122.17 N/mm [95% CI 71.99 to 375.37]; p = 0.92). CONCLUSION: Transcutaneous application of CO2 accelerated bone generation in a distraction osteogenesis model of rabbit tibias. As demonstrated in previous studies, CO2 treatment might affect bone regeneration in distraction osteogenesis by promoting angiogenesis, blood flow, and endochondral ossification. CLINICAL RELEVANCE: The use of the transcutaneous application of CO2 may open new possibilities for shortening healing time in patients with distraction osteogenesis. However, a deeper insight into the mechanism of CO2 in the local tissue is required before it can be used in future clinical practice.

  Aug. 2020, Clinical orthopaedics and related research, 478(8) (8), 1922 - 1935, English, International magazine

  Scientific journal


• Prognostic influence of the treatment approach for pulmonary metastasis in patients with soft tissue sarcoma.

  Teruya Kawamoto, Hitomi Hara, Masayuki Morishita, Naomasa Fukase, Yohei Kawakami, Toshiyuki Takemori, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Takuya Fujimoto, Ikuo Fujita, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue

  Soft tissue sarcomas (STSs) are rare heterogeneous malignancies of mesenchymal origin. Pulmonary metastases develop in approximately 50% of the patients with high-grade STS, being the major cause of mortality in patients with metastatic STS. Pulmonary metastasectomy has been reported to contribute to long-term survival; however, an appropriate treatment has not been established. We aimed to identify factors associated with post-metastasis survival in STS patients with pulmonary metastasis and determine the appropriate treatment for each patient. We retrospectively reviewed the records of metastatic STS patients treated between 2000 and 2017 and analyzed the clinico-pathologic variables to identify factors associated with the survival. The median survival after pulmonary metastasis was 20.6 months, and the 1-, 3-, and 5-year survival rates were 68.6%, 36.0%, and 25.1%, respectively. The survival was significantly greater in patients who underwent pulmonary metastasectomy than in those without surgery (38.9 months vs. 10.5 months; p < 0.0001). Among those who did not undergo surgery, the survival was significantly greater in patients who received chemotherapy than in those without chemotherapy (19.1 months vs. 6.3 months, p = 0.037). Multivariate analysis identified pulmonary metastasectomy as the most important prognostic factor for post-metastasis survival (Hazard ratio 5.623; 95% Confidence Interval 2.733-11.572; p < 0.0001). In conclusion, pulmonary metastasectomy was the most important prognostic factor for post-metastasis survival in patients with metastatic STS. In addition, chemotherapy could prolong survival in patients who were not eligible for pulmonary resection. Although we should carefully weigh the risks and benefits, appropriate treatment for pulmonary metastases could contribute to long-time survival.

  Aug. 2020, Clinical & experimental metastasis, 37(4) (4), 509 - 517, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Greater knee joint laxity remains in teenagers after anatomical double-bundle anterior cruciate ligament reconstruction compared to young adults.

  Yuta Nakanishi, Takehiko Matsushita, Kanto Nagai, Daisuke Araki, Noriyuki Kanzaki, Yuichi Hoshino, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda

  PURPOSE: There is paucity in studies regarding double-bundle anterior cruciate ligament reconstruction (DB-ACLR) in teenagers. The purpose of this study is to investigate clinical outcome after DB-ACLR and analyze whether any differences exist between teenagers and young adults. METHODS: A retrospective study was performed between 2009 and 2017. Teenagers were defined as patients between 15 and 19 years and young adults between 20 and 25 years old. Isolated anterior cruciate ligament (ACL) injuries with DB-ACLR with minimum two-year follow up were included. Pre and post-operative Lysholm score, Tegner activity scale, KT-2000 arthrometer, manual pivot-shift grade, were assessed with post-operative one-leg hop test, isokinetic knee extensor strength test at 60°/sec, International Knee Documentation Committee Score (IKDC score), and re-injury rate. RESULTS: One-hundred and thirty-one patients, 75 patients in the teenage group (Group A) and 56 patients in the young adult group (Group B), were enrolled. Lysholm score was significantly lower in Group A (89.6 ± 21.1) compared to Group B (95.9 ± 4.6) (p = 0.04). Side to side difference in KT-2000 arthrometer (2.3 ± 2.2 mm vs 1.0 ± 2.3 mm, Group A vs Group B, respectively, p < 0.01) and ratio of post-operative positive pivot shift was significantly greater in Group A (30.7%) compared to Group B (7.1%) (p < 0.01). No significant difference was seen in re-injury rate (n.s.). CONCLUSION: Teenage patients have a greater tendency for residual knee joint laxity after DB-ACLR. Although teenagers and patients in the early twenties are close in age, characteristic in knee joint laxity may be different and, therefore, may require attention upon surgery and post-operative follow-up. LEVEL OF EVIDENCE: III.

  Aug. 2020, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 28(8) (8), 2663 - 2667, English, International magazine

  [Refereed]

  Scientific journal


• Soluble CD14 Induces Pro-inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-Like Synovial Cells via Toll-Like Receptor 4.

  Yoshihide Ichise, Jun Saegusa, Shino Tanaka-Natsui, Ikuko Naka, Shinya Hayashi, Ryosuke Kuroda, Akio Morinobu

  OBJECTIVES: Synovial fluids of rheumatoid arthritis (RA) patients commonly contain high concentrations of soluble CD14 (sCD14). To investigate its potential role in RA pathogenesis, we tested whether sCD14 binding transmits a signal to fibroblast-like synoviocytes from RA patients (RA-FLS). METHODS: The induction of pro-inflammatory cytokines, chemokines, and mediators by sCD14 stimulation of RA-FLS was quantified by real-time PCR and ELISA. Cell proliferation was assessed by the BrdU assay. LPS-RS, a Toll-like receptor 4 (TLR-4) antagonist, was used to block TLR-4 signaling. RESULTS: Soluble CD14 induced the expression of IL-6 mRNA and secretion of the protein. The expression of other pro-inflammatory cytokines and mediators, such as TNF-α, IL-8, intercellular adhesion molecule-1 (ICAM-1), MMP-3, and RANK ligand (RANKL), was also induced by sCD14. In addition, sCD14 stimulation promoted RA-FLS proliferation. LPS-RS abolished IL-6, IL-8, and ICAM-1 mRNA induction by sCD14 in RA-FLS. On the other hand, TNF-α and IL-17A increased TLR-4 expression by RA-FLS and amplified their sCD14-induced IL-6 expression. CONCLUSIONS: Soluble CD14 transmits inflammatory signals to RA-FLS via TLR-4. The effects of sCD14 may be augmented in inflammatory milieu. Our results suggest that sCD14 is involved in the pathogenesis of RA and may be a novel therapeutic target.

  Jul. 2020, Cells, 9(7) (7), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Erratum to "Guideline Japanese Orthopaedic Association 2019 guidelines for anterior cruciate ligament injuries" (3rd edition) [Journal of Orthopaedic Science, 25 (1) (Jan 2020) 6-45].

  Yasuyuki Ishibashi, Nobuo Adachi, Hideyuki Koga, Eiji Kondo, Ryosuke Kuroda, Tatsuo Mae, Yuji Uchio

  Jul. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, English, Domestic magazine


• Evaluation of the accuracy of acetabular cup orientation using the accelerometer-based portable navigation system.

  Shinya Hayashi, Shingo Hashimoto, Koji Takayama, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Takaaki Fujishiro, Takafumi Hiranaka, Takahiro Niikura, Ryosuke Kuroda

  BACKGROUND: Accurate orientation of acetabular and femoral components is important during total hip arthroplasty (THA). In recent years, several navigation systems have been developed. However, these navigation systems for THA are unpopular worldwide because of their high cost. We assessed the orientation accuracy of cups inserted using a disposable accelerometer-based portable navigation system for THAs. METHODS: This was a prospective cohort study. We analyzed 63 hips with navigation prospectively and 30 hips without navigation retrospectively as historical control. The patients underwent THA via the mini anterolateral approach in the supine position using an accelerometer-based portable navigation system. We compared the preoperative target angles, intraoperative cup angles using navigation records, postoperative angles using postoperative CT data, measurement errors of cup angles, and clinical parameters such as sex, treated side, age at surgery, and body mass index (BMI). RESULTS: The average absolute error (postoperative CT-navigation record) was 2.7 ± 2.1° (inclination) and 2.7 ± 1.8° (anteversion), and the absolute error (postoperative CT-preoperative target angle) was 2.6 ± 1.9° (inclination) and 2.7 ± 2.2° (anteversion). The absolute error between postoperative CT and target angle with navigation was significantly lower than the error without navigation (inclination; p = 0.025, anteversion; p = 0.005). Cup malalignment (absolute difference of inclination or anteversion between postoperative CT and preoperative target angle of over 5°) was significantly associated with BMI value (OR: 1.3, 95% CI: 1.1-1.7). The absolute measurement error of cup inclination and anteversion was significantly correlated with patients' BMI (inclination error: correlation coefficient = 0.53, p < 0.001, anteversion error: correlation coefficient = 0.58, p < 0.001). CONCLUSIONS: The clinical accuracy of accelerometer-based portable navigation is precise for the orientation of cup placement, although accurate cup placement was affected by high BMI. This is the first study to report the accuracy of accelerometer-based portable navigation for THA in the supine position.

  Jul. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(4) (4), 612 - 617, English, Domestic magazine

  [Refereed]

  Scientific journal


• 滑膜肉腫の治療成績

  河本 旭哉, 森下 雅之, 藤田 郁夫, 原 仁美, 川上 洋平, 竹森 俊幸, 藤原 周一, 北山 和道, 八尋 俊輔, 藤本 卓也, 中松 裕太, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jul. 2020, 日本整形外科学会雑誌, 94(6) (6), S1449 - S1449, Japanese


• 骨肉腫細胞における特定因子導入を用いたがん幹細胞特性の獲得

  藤原 周一, 河本 旭哉, 川上 洋平, 小寺澤 康文, 原 仁美, 竹森 俊幸, 北山 和道, 八尋 俊輔, 青井 貴之, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jul. 2020, 日本整形外科学会雑誌, 94(6) (6), S1525 - S1525, Japanese


• がん骨転移における骨破壊に寄与するmiRNAの探索

  北山 和道, 河本 旭哉, 原 仁美, 深瀬 直政, 川上 洋平, 竹森 俊幸, 藤原 周一, 八尋 俊輔, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jul. 2020, 日本整形外科学会雑誌, 94(6) (6), S1546 - S1546, Japanese


• 骨・軟部肉腫による脳転移例の検討

  竹森 俊幸, 森下 雅之, 河本 旭哉, 藤田 郁夫, 原 仁美, 川上 洋平, 藤原 周一, 北山 和道, 八尋 俊輔, 藤本 卓也, 黒田 良祐, 秋末 敏宏

  (公社)日本整形外科学会, Jul. 2020, 日本整形外科学会雑誌, 94(6) (6), S1548 - S1548, Japanese


• 【骨代謝研究の臨床応用】難治性骨折の骨癒合促進

  黒田 良祐, 新倉 隆宏

  (株)北隆館, Jul. 2020, BIO Clinica, 35(7) (7), 614 - 619, Japanese


• 骨粗鬆症外来における機械学習を用いた骨密度予測

  乾 淳幸, 西本 華子, 美舩 泰, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Jul. 2020, 中部日本整形外科災害外科学会雑誌, 63(4) (4), 631 - 632, Japanese


• 脊椎腫瘍に対するseparation surgeryとIMRTの併用による治療成績 7例のケースシリーズ

  神田 裕太郎, 角谷 賢一朗, 酒井 良忠, 由留部 崇, 張 鍾穎, 垣内 裕司, 武岡 由樹, 辻本 龍, 宮崎 邦彦, 宮崎 真吾, 高田 徹, 黒田 良祐

  (公社)日本整形外科学会, Jul. 2020, 日本整形外科学会雑誌, 94(6) (6), S1528 - S1528, Japanese


• 女医歴14年、子育て歴7年 今までやってきたこと、これからやりたいこと

  原田 理沙, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), S419 - S419, Japanese


• 集中治療室に緊急で入室した患者の自宅退院可否についての検討

  松本 健, 原田 理沙, 大西 宏和, 今村 愛生, 吉川 遼, 三浦 靖史, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 1 - 3, Japanese


• 市中回復期病棟におけるタンパク質強化栄養補助食品による栄養介入の効果

  松本 健, 大西 宏和, 今村 愛生, 吉川 遼, 三浦 靖史, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 1 - 2, Japanese


• 入院中のリハビリテーション治療中に転移性骨腫瘍による病的骨折を起こした2例

  吉川 遼, 酒井 良忠, 大西 宏和, 今村 愛生, 松本 健, 原田 理沙, 井上 順一朗, 新倉 隆宏, 黒田 良祐

  (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 1 - 5, Japanese


• 小脳性運動失調に対しRehabwareを用いてVirtual Reality課題を実施した一症例

  大川 直子, 乾 淳幸, 村中 由香, 伊藤 智永子, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 1 - 8, Japanese


• ベッドサイドにおけるエコーを用いた筋厚測定の信頼性評価について

  大西 宏和, 松本 健, 今村 愛生, 吉川 遼, 原田 理沙, 三浦 靖史, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 3 - 1, Japanese


• プロ野球投手の肩関節コンディションと股関節可動域スコアの関係

  美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 3 - 1, Japanese


• プロ野球投手におけるGlenohumeral internal rotation deficit(GIRD)に関連する因子の検討

  美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 3 - 2, Japanese


• Leap Motionを使用した仮想空間上での母指運動の評価

  乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 4 - 3, Japanese


• 膝スポーツ損傷に対するリハビリテーション医療

  黒田 良祐, 松下 雄彦, 酒井 良忠

  (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), S197 - S197, Japanese


• 頸椎転移患者の手術成績と成績不良因子の検討 PS、QOLの推移から

  神田 裕太郎, 角谷 賢一朗, 酒井 良忠, 由留部 崇, 垣内 裕司, 武岡 由樹, 辻本 龍, 河本 旭哉, 原 仁美, 秋末 敏宏, 黒田 良祐

  (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 3 - 2, Japanese


• 骨粗鬆症外来における機械学習を用いた骨密度予測

  乾 淳幸, 西本 華子, 美舩 泰, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Jul. 2020, 中部日本整形外科災害外科学会雑誌, 63(4) (4), 631 - 632, Japanese


• Predictors of Health-Related Quality of Life After Revision Total Hip Arthroplasty for Aseptic Loosening.

  Yuichi Kuroda, Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Ryosuke Kuroda

  Background: Few studies have investigated the relationships between preoperative or intraoperative patient factors and postoperative quality of life (QOL) after revision total hip arthroplasty (THA). The aim of our study was to identify the predictors of QOL after revision THA for aseptic loosening. Materials and Methods: Fifty-one patients who underwent revision THA for aseptic loosening were included in the present study. Preoperative hip function was evaluated using the Japanese Orthopaedic Association (JOA) score. The patients' QOL after surgery was evaluated with EuroQol 5D (EQ-5D) assessment at the end of the 2-year follow-up. The patients were then divided into two groups: good QOL (score ≥ 0.6) and poor QOL (score < 0.6). Predictive factors (i.e., age, BMI, preoperative JOA score, and the degree of acetabular bone defect according to the Paprosky classification) were compared between both QOL groups. Furthermore, multiple linear regression was performed to assess independent factors affecting the QOL. Results: Significant differences between the good and poor QOL groups were identified for BMI, walking ability, and severity of acetabular bone defect (BMI: 21.5 ± 2.9 vs. 24.1 ± 4.3, P = 0.0331; walking ability: 11.5 ± 5.0 vs. 5.5 ± 4.9, P = 0.0058; acetabular bone defect: 44.4% vs. 81.0%, P = 0.0103). The walking ability independently affected the EQ-5D utility score. Conclusions: The present study indicates that a higher BMI, lower walking ability, and more severe acetabular bone defect are predictors of lower QOL after revision THA for aseptic loosening. In particular, the walking ability was the only independent factor. Thus, surgeons should pay attention to the postoperative management of patients with these risk factors.

  Jul. 2020, Indian journal of orthopaedics, 54(4) (4), 463 - 468, English, International magazine

  Scientific journal


• Plantar pressure sensors indicate women to have a significantly higher peak pressure on the hallux, toes, forefoot, and medial of the foot compared to men.

  Tetsuya Yamamoto, Yuichi Hoshino, Noriyuki Kanzaki, Koji Nukuto, Takahiro Yamashita, Kazuyuki Ibaraki, Kouki Nagamune, Kanto Nagai, Daisuke Araki, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Sex-related differences of plantar pressure distribution during activities should be thoroughly inspected as it can help establish treatment and prevention strategies for foot and ankle problems. In-shoe measurement systems are preferable without space and activity restrictions; however, previously reported systems are still heavy and bulky and induce unnatural movement. Therefore, a slim and light plantar pressure sensor was newly developed to detect the effect of sex difference on plantar pressure during standing and walking. METHODS: One-hundred healthy adult volunteers (50 women and 50 men) were recruited. Ten plantar pressure sensors were implanted in a 1-mm thick insole, with a total weight of 29 g. Plantar pressure was recorded with 200 Hz during 3 s of standing and while walking 10 steps. The maximum loads during standing and walking were analyzed in each sensor, and the results were compared between different areas of the foot in the antero-posterior direction and the medio-lateral direction and between different time points. The movement of the center of pressure (COP) during walking was also evaluated. Analyses were adjusted for body mass index and gait speed. RESULTS: The movement of COP was constant for both sexes. In all cases, the maximum load was observed on the medial of the foot. Women had a significantly higher peak pressure on the hallux, toes, forefoot, and medial aspect of the foot compared to men while standing and walking (p < .05). CONCLUSIONS: A newly introduced in-shoe plantar pressure sensor demonstrated a typical loading transition pattern of the foot. Furthermore, higher plantar pressure in the forefoot was detected in healthy women as compared to men during standing and walking activities.

  Jul. 2020, Journal of foot and ankle research, 13(1) (1), 40 - 40, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Radial Meniscal Tears Are Best Repaired by a Modified "Cross" Tie-Grip Suture Based on a Biomechanical Comparison of 4 Repair Techniques in a Porcine Model.

  Yuta Nakanishi, Yuichi Hoshino, Kouki Nagamune, Tetsuya Yamamoto, Kanto Nagai, Daisuke Araki, Noriyuki Kanzaki, Takehiko Matsushita, Ryosuke Kuroda

  Background: The tie-grip suture can fix radial tears more rigidly than simple conventional sutures. However, one shortcoming is the residual gap at the central margin of the tear. The tie-grip suture was modified to address this issue and named the "cross tie-grip suture." Purpose/Hypothesis: The purpose of this study was to compare the suture stability and strength among 4 suturing techniques: the original tie-grip, cross tie-grip, and 2 conventional sutures (double horizontal and cross). It was hypothesized that the cross tie-grip suture would show the least displacement and resist the greatest maximum load. Study Design: Controlled laboratory study. Methods: A total of 40 fresh-frozen porcine knees were dissected to acquire 80 menisci; 20 menisci were tested in each suture group. A radial tear was created at the middle third of the meniscal body. Repair was performed with the following: original tie-grip, cross tie-grip, double horizontal, and cross sutures. The mechanical strength of sutured menisci was evaluated using a tensile testing machine. All menisci underwent submaximal loading and load to failure. The gap distance and ultimate failure load were compared using analysis of variance. The failure mode was recorded after load-to-failure testing. Results: Displacement after 500 cycles was significantly smaller in the cross tie-grip group (0.4 ± 0.3 mm) compared with the tie-grip (0.9 ± 0.6 mm), double horizontal (1.2 ± 0.7 mm), and cross suture groups (1.4 ± 0.6 mm) (P < .05). The ultimate failure load was significantly greater in the cross tie-grip (154.9 ± 29.0 N) and tie-grip (145.2 ± 39.1 N) groups compared with the double horizontal (81.2 ± 19.9 N) and cross suture groups (87.3 ± 17.7 N) (P < .05). Tissue failure was the most common mode of failure in all groups. Conclusion: Upon repair of radial meniscal tears, the cross tie-grip suture showed less displacement compared with that of the tie-grip, double horizontal, and cross sutures and demonstrated equivalent load to failure to that of the tie-grip suture at time zero. Clinical Relevance: The cross tie-grip suture provided high resistance to displacement after repair of radial tears and may be advantageous in healing for radial meniscal tears.

  Jul. 2020, Orthopaedic journal of sports medicine, 8(7) (7), 2325967120935810 - 2325967120935810, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Subcapital Fracture with Avascular Necrosis of the Whole Femoral Head After Fixation of an Intertrochanteric Fracture: A Case Report.

  Natsuko Fukuoka, Keisuke Oe, Atsushi Sakurai, Takahiro Niikura, Ryosuke Kuroda, Tetsuji Yamamoto

  Introduction: Subcapital fractures following internal fixation of an intertrochanteric fracture are relatively rare. It has been reported that these fractures are caused by improper placement of implants, osteoporosis, and any trauma episode. We report a rare case of subcapsular fracture possibly caused by whole femoral head necrosis following intertrochanteric fracture treatment. Case Report: An 88-year-old woman fell and sustained an intertrochanteric fracture of the left femur. She was treated with a short femoral nail (SFN) and 3 months after the surgery, bone union was observed. One year after the internal fixation of the intertrochanteric fracture, she complained of the left hip joint pain without any trauma, and the X-ray showed a subcapital fracture of the femur. She underwent nail removal and was treated with a bipolar hemiarthroplasty. Magnetic resonance imaging showed a change in the signal intensity of the entire head, and pathological findings revealed osteonecrosis. Normally, the reaction of bone resorption occurs below the necrosis area. We believe that the avascular necrosis (AVN) of the whole femoral head made the subcapital area fragile, resulting in a subcapital fracture. Conclusions: We should consider AVN of the whole femoral head as a potential cause of subcapital fracture after SFN fixation of intertrochanteric fractures.

  Jul. 2020, Journal of orthopaedic case reports, 10(4) (4), 42 - 44, English, International magazine


• Solitary pancreatic lesion as the initial metastasis from osteosarcoma: Report of a rare case.

  Kemmei Ikuta, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Masayuki Morishita, Ryosuke Kuroda, Toshihiro Akisue

  Jul. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(4) (4), 724 - 728, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Anterior placement of the talar component in total ankle arthroplasty: A risk factor for talar component subsidence.

  Tetsuya Yamamoto, Kanto Nagai, Noriyuki Kanzaki, Koji Nukuto, Takahiro Yamashita, Kazuyuki Ibaraki, Daisuke Araki, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Component subsidence is considered as a cause of revision surgery. The talar component subsidence may be a risk factor for revision surgery; however, there are no reports regarding talar component placement and subsidence amount following total ankle arthroplasty (TAA). We therefore investigated the relationship between talar component placement and subsidence amount. METHODS: Fifty-two ankles from 49 patients (age: 71 years [range 62-83], 13 male/ 36 female), who underwent TAA with mean follow-up of 36 months (range 12-83), were included. The subjects were divided into two groups based on talar component placement: anterior placement (n = 20, group A) and posterior placement (n = 32, group P) using weight-bearing lateral plain radiographs. The amount of the talar component subsidence and clinical outcomes, which included the Japanese Society for Surgery of the Foot (JSSF) scale, range of the motion (ROM) and the revision rate, were compared between the groups. RESULTS: Talar component subsidence was significantly higher in group A (2.1 ± 2.0 mm) than in group P (0.6 ± 1.4 mm, P = .017). There was no significant difference in the JSSF scale and ROM between group A and group P. The revision rate was 10.0% in group A and 6.3% in group P, albeit not statistically significant. CONCLUSION: Greater talar component subsidence was observed when the talar component was placed more anteriorly, suggesting that anterior placement of the talar component may need to be avoided during the surgery in order to minimize the postoperative talar component subsidence.

  Jun. 2020, Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons, English, International magazine

  Scientific journal


• Comparison of intraoperative soft tissue balance measurement between two tensor systems in total knee arthroplasty.

  Yoshinori Takashima, Koji Takayama, Kazunari Ishida, Hirotsugu Muratsu, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: Differences in measurement outcomes using different tensors in total knee arthroplasty (TKA) remain unknown. This study aimed to compare intraoperative soft tissue balance between two measurement systems in TKA. METHODS: This study included 24 cruciate-retaining (CR) and 27 posterior-stabilized (PS) TKAs for varus-type osteoarthritis. All TKAs were performed with the measured resection technique. Intraoperative soft tissue balance was assessed with femoral component placement and patellofemoral joint reduction throughout the range of motion. Measurements were performed using the Offset Repo-Tensor (Zimmer) and Ligament Sensor Tensor (Depuy). Joint component gaps and varus/valgus ligament balance were compared statistically in CR and PS TKAs. RESULTS: Joint component gaps with the Offset Repo-Tensor were significantly larger at 0°, 10°, 30°, and 60° of knee flexion in CR TKA and at all knee flexion angles, except 0° and 135°, in PS TKA than those with the Ligament Sensor Tensor (P < .05). Varus balance with the Offset Repo-Tensor was significantly larger at 0°, 10°, and 30° of knee flexion in CR TKA and at 10°, 30°, 60°, 90°, and 120° of knee flexion in PS TKA than that with the Ligament Sensor Tensor (P < .05). CONCLUSION: Surgeons should consider the discrepancy in assessing intraoperative soft tissue balance depending on the tensor used. The Ligament Sensor Tensor tended to underestimate soft tissue balance in CR and PS TKAs compared with the Offset Repo-Tensor, especially in PS TKA. Thus, surgeons should know the difference in values between the offset-type tensor with consistent distraction force and a spring-loaded tensor.

  Jun. 2020, The Knee, 27(3) (3), 1071 - 1077, English, International magazine

  Scientific journal


• Mobile-bearing insert reduced patellar contact force at knee flexion during posterior stabilized total knee arthroplasty.

  Yuichi Kuroda, Koji Takayama, Shinya Hayashi, Shingo Hashimoto, Masanori Tsubosaka, Tomoyuki Kamenaga, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: This study aimed to compare tibial rotation and patellar contact force between mobile- and fixed-bearing total knee arthroplasty from extension to flexion by using a navigation system and patellar contact force sensor on the same patients' knees. METHODS: Thirty-one consecutive patients who had undergone a primary posterior stabilized total knee arthroplasty were included. Patellar contact forces on the medial and lateral sides were measured at each flexion angle, and tibial rotation was assessed during 30-90°, and 90-120° knee flexion. The patellar contact force and tibial rotation were measured twice with the mobile- and fixed-platform trial components and compared between the two groups. FINDINGS: The patellar contact force was significantly lower with mobile than with fixed-bearing total knee arthroplasty on the medial side at 120° flexion (P = .0138) and lateral side at 60°, 90°, and 120° flexion (P = .0346, P = .0127, and P = .0376). There were no significant differences in tibial rotation between the mobile- and fixed-bearing inserts during both 30-90° and 90-120° knee flexion. INTERPRETATION: Patellar contact force was significantly lower, especially on the lateral side in mobile than in fixed-bearing total knee arthroplasty, whereas no significant difference in tibial internal rotation was found between the two inserts. Mobile-bearing inserts might reduce the patellar contact force by the bearing rotation, rather than natural tibial rotation during posterior stabilized total knee arthroplasty.

  Jun. 2020, Clinical biomechanics (Bristol, Avon), 76, 105022 - 105022, English, International magazine

  Scientific journal


• Clinical experience of the use of reamer irrigator aspirator in Japanese patients: A report of the first 42 cases.

  Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: A reamer irrigator aspirator (RIA) can be used to harvest substantial amounts of autologous bone and debride the intramedullary canal. Clinical experience using reamer irrigator aspirators in Japan is very limited. The applicability of the reamer irrigator aspirator head with a minimum diameter of 12 mm for Japanese people is often questioned as the Japanese are smaller than Americans and Europeans. There are no reports of complications in Japanese patients. This study aimed to retrospectively review clinical cases and describe reamer irrigator aspirator use in Japanese patients. METHODS: All patients for whom a reamer irrigator aspirator was used during surgery at our hospital between January 2014 and September 2018 were included. The patients' clinical and radiographic data were retrospectively reviewed. RESULTS: Data of 40 patients (42 cases) were collected. The reamer irrigator aspirator was used for bone graft harvesting in 32 cases, intramedullary debridement and irrigation in 9 cases, and reaming for exchange nailing in 1 case. The diameter of the reamer irrigator aspirator reamer head was 12 mm in 22 cases (53.7%), 12.5 mm in 4 cases (9.8%), 13 mm in 9 cases (22.0%), 13.5 mm in 1 case (2.4%), 14.0 mm in 1 case (2.4%), 14.5 mm in 1 case (2.4%), and 15 mm in 4 cases (9.8%). Mean intraoperative bleeding volume was 1158.6 mL (range, 100-3800 mL). We experienced no difficulty inserting the reamer irrigator aspirator into the intramedullary canals and no cases of insertion-related intraoperative fracture. Five cortical perforations (11.9%) were observed on postoperative computed tomography scans, although no patient was symptomatic. One case (2.4%) of postoperative femur fracture occurred. CONCLUSIONS: Reamer irrigator aspirators can be used in Japanese patients. Smaller reamer head sizes were mainly used in our experience. We should manage complications as in previous reports from Western countries.

  May 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 26(3) (3), 459 - 465, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Intraoperative pelvic movement is associated with the body mass index in patients undergoing total hip arthroplasty in the supine position.

  Tomoyuki Kamenaga, Shinya Hayashi, Shingo Hashimoto, Koji Takayama, Takaaki Fujishiro, Takafumi Hiranaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUNDS: There are very few reports on pelvic movement during total hip arthroplasty (THA) in the supine position. We investigated intraoperative pelvic motion in the sagittal and axial planes to determine if preoperative clinical factors, including body mass index (BMI) affect intraoperative pelvic motion. METHODS: Fifty-three patients with osteoarthritis undergoing THA in the supine position were included. Clinical factors, such as age, BMI, and pelvic tilt were assessed preoperatively. Intraoperative pelvic motion in the axial and sagittal planes was assessed using a portable navigation system. We assessed the change in pelvic tilt from registration to cup implantation as the pelvic tilt change; positive values indicated anterior pelvic tilt. We measured the values and absolute values of changes in axial rotation from registration to cup implantation to determine the axial rotation angle. The effects of patient factors on pelvic motion (pelvic tilt change and axial rotation angle) were analyzed using a Spearman's correlation analysis. RESULTS: Preoperative pelvic tilt was negatively correlated with pelvic tilt change (r = -0.57, p < 0.05) and the absolute axial rotation angle (r = -0.57, p < 0.05). BMI and absolute axial rotation angle were negatively correlated (r = -0.54, p < 0.05). Age was not correlated with change in the pelvic tilt and the axial rotation angle. CONCLUSIONS: Preoperative pelvic tilt and BMI are important factors to determine intraoperative pelvic motion in patients who undergo THA in the supine position. This can help surgeons to preoperatively identify patients with a higher risk of intraoperative pelvic motion.

  May 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(3) (3), 446 - 451, English, Domestic magazine

  [Refereed]

  Scientific journal


• 前十字靱帯再建術後再鏡視膝関節鏡術後に生じた仮性動脈瘤の1例

  岡田 亮, 松下 雄彦, 星野 祐一, 神崎 至幸, 荒木 大輔, 長井 寛斗, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, May 2020, 中部日本整形外科災害外科学会雑誌, 63(3) (3), 503 - 503, Japanese


• Prediction of intra-articular pathology and arthroscopic outcomes for femoroacetabular impingement and labral tear based on the response to preoperative anaesthetic hip joint injections.

  Nobuaki Chinzei, Shingo Hashimoto, Shinya Hayashi, Koji Takayama, Tomoyuki Matsumoto, Ryosuke Kuroda

  OBJECTIVE: This study investigated whether the preoperative response to intra-articular injections is associated with intra-articular pathological findings and arthroscopy outcomes. METHODS: This study included 49 patients who underwent arthroscopic hip surgery for femoroacetabular impingement and labral tear after receiving preoperative hip joint injections. The response to anaesthetic injections was categorized as poor (0-50%) or good (51-100%). With respect to anatomical indices, we evaluated the lateral centre-edge angle (LCEA), acetabular roof obliquity (ARO), vertical-centre-anterior angle (VCA), and the alpha angle (on a lateral view). We evaluated the association between these indices (including the types of hip labral tears and cartilage damage) and the effectiveness of intra-articular injections. RESULTS: The study included 22 men and 27 women, and the mean age of patients was 36.4 years. No statistically significant association was observed between the response to preoperative anaesthetic hip joint injections and patient demographics (age, sex) and anatomical indices (LCEA, ARO, VCA, and alpha angle) (p > 0.05). All patients showed labral damage; however, labral tear classification or cartilage damage was not significantly associated with the effectiveness of joint injections. At the 1-year post-operative follow-up, patients with a good response to anaesthetic hip joint injections showed a significantly better outcome than patients with a poor response to these injections (p < 0.01). CONCLUSION: The response to preoperative anaesthetic hip joint injections may indicate the presence of intra-articular pathology. Furthermore, this association may have predictive value in determining post-operative outcomes following hip arthroscopy.

  May 2020, European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 30(4) (4), 737 - 742, English, International magazine

  Scientific journal


• Deletion of p21 expression accelerates cartilage tissue repair via chondrocyte proliferation.

  Kazuyuki Ibaraki, Shinya Hayashi, Noriyuki Kanzaki, Shingo Hashimoto, Shinsuke Kihara, Masahiko Haneda, Kazuhiro Takeuchi, Takahiro Niikura, Ryosuke Kuroda

  Articular cartilage tissue has a poor healing potential, and when subjected to traumatic damage this tissue undergoes cartilage degeneration and osteoarthritis. The association between the regulation of cell cycle checkpoints and tissue regeneration has been previously investigated, and p21 was initially identified as a potent inhibitor of cell cycle progression. However, the effects of p21 defects on damaged tissue remain controversial. Therefore, the aim of the present study was to evaluate the effects of p21 deficiency on cartilage repair. A mouse model of articular cartilage repair was generated by inducing a patellar groove scratch in 8‑week‑old p21‑knockout (KO) mice and C57Bl/6 wild‑type (WT) mice. Mice were sacrificed at 4 and 8 weeks post‑surgery. The present study also investigated the effect of p21 deficiency on cartilage differentiation in ATDC5 cells in vitro. Safranin O staining results indicated that cartilage repair initially occurred in p21 KO mice. In addition, immunohistochemical analysis demonstrated that p21 KO upregulated proliferating cell nuclear antigen and increased cell proliferation. However, type II collagen and Sox9 expression levels remained unchanged in p21 KO and WT mice. Moreover, it was identified that p21 downregulation did not affect Sox9 and type II collagen expression levels in vitro. Furthermore, p21 deficiency promoted healing of articular cartilage damage, which was associated with cell proliferation in vivo, and increased chondrocyte proliferation but not differentiation in vitro. Therefore, the present results suggested that p21 does not affect Sox9 or type II collagen expression levels during cartilage differentiation in the repair of cartilage defects.

  May 2020, Molecular medicine reports, 21(5) (5), 2236 - 2242, English, International magazine

  Scientific journal


• The Influences of Chronicity and Meniscal Injuries on Pivot Shift in Anterior Cruciate Ligament-Deficient Knees: Quantitative Evaluation Using an Electromagnetic Measurement System.

  Kyohei Nishida, Takehiko Matsushita, Yuichi Hoshino, Daisuke Araki, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda

  PURPOSE: To investigate the influences of time from injury to surgery and meniscal injuries on knee rotational laxity in anterior cruciate ligament (ACL)-deficient knees using the electromagnetic system retrospectively. METHODS: Ninety-four unilateral ACL-injured patients (44 male and 50 female, mean age: 27.3 ± 11.8 years) were included. The pivot-shift test was performed before ACL reconstruction, as was a quantitative evaluation using the electromagnetic system to determine tibial acceleration. Patients were divided into 4 groups according to the chronicity: group 1, within 3 months (22 patients); group 2, between 3 and 6 months (29 patients); group 3, between 6 and 12 months (23 patients); and group 4, more than 12 months (20 patients). The presence of meniscal injuries was examined arthroscopically. RESULTS: The tibial acceleration was significantly greater in group 4. There was a positive correlation between tibial acceleration and the time from injury to surgery (r = 0.47, P = .02). In groups 1, 2 and 3, the tibial acceleration in patients with a lateral meniscal injury was significantly greater than in patients with a medial meniscal injury and without meniscal injury. When patients with lateral meniscal injury were excluded (leaving those with medial meniscus injury or without meniscal injury), group 4 had significantly greater accelerations than other groups. CONCLUSIONS: In ACL-deficient knees, rotational laxity increased with time and the increased rotational laxity was evident more than 1 year after injury whereas it increased with concomitant lateral meniscal injuries within 1 year after injury. LEVEL OF EVIDENCE: Ⅳ, diagnostic study of nonconsecutive patients.

  May 2020, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 36(5) (5), 1398 - 1406, English, International magazine

  [Refereed]

  Scientific journal


• The predictive value of synovial glucose level in septic arthritis.

  Maki Kinugasa, Daisuke Kobayashi, Shinichi Satsuma, Ryosuke Sakata, Yoshiyuki Shinada, Ryosuke Kuroda

  The aim of this study was to investigate the ability of the joint fluid glucose level to detect septic arthritis. Thirty joints in 30 patients with suspected septic arthritis were evaluated. When glucose level was less than 40 mg/dl, we performed arthrotomy. Eleven patients had joint fluid glucose levels less than 40 mg/dl. All 11 (100%) had positive joint fluid cultures. Conversely, 19 patients had synovial glucose levels of at least 40 mg/dl. Six (31.6%) of these had positive joint fluid cultures. The remaining 13 were diagnosed with transient synovitis. Patients with joint fluid glucose levels less than 40 mg/dl should be suspected septic arthritis.

  May 2020, Journal of pediatric orthopedics. Part B, 29(3) (3), 292 - 296, English, International magazine

  [Refereed]

  Scientific journal


• Altered microRNA profile during fracture healing in rats with diabetes.

  Shunsuke Takahara, Sang Yang Lee, Takashi Iwakura, Keisuke Oe, Tomoaki Fukui, Etsuko Okumachi, Michio Arakura, Yoshitada Sakai, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that regulate gene expression. There is increasing evidence that some miRNAs are involved in the pathology of diabetes mellitus (DM) and its complications. We hypothesized that the functions of certain miRNAs and the changes in their patterns of expression may contribute to the pathogenesis of impaired fractures due to DM. METHODS: In this study, 108 male Sprague-Dawley rats were divided into DM and control groups. DM rats were created by a single intravenous injection of streptozotocin. Closed transverse femoral shaft fractures were created in both groups. On post-fracture days 5, 7, 11, 14, 21, and 28, miRNA was extracted from the newly generated tissue at the fracture site. Microarray analysis was conducted with miRNA samples from each group on post-fracture days 5 and 11. The microarray findings were validated by real-time polymerase chain reaction (PCR) analysis at each time point. RESULTS: Microarray analysis revealed that, on days 5 and 11, 368 and 207 miRNAs, respectively, were upregulated in the DM group, compared with the control group. The top four miRNAs on day 5 were miR-339-3p, miR451-5p, miR-532-5p, and miR-551b-3p. The top four miRNAs on day 11 were miR-221-3p, miR376a-3p, miR-379-3p, and miR-379-5p. Among these miRNAs, miR-221-3p, miR-339-3p, miR-376a-3p, miR-379-5p, and miR-451-5p were validated by real-time PCR analysis. Furthermore, PCR analysis revealed that these five miRNAs were differentially expressed with dynamic expression patterns during fracture healing in the DM group, compared with the control group. CONCLUSIONS: Our findings will aid in understanding the pathology of impaired fracture healing in DM and may support the development of molecular therapies using miRNAs for the treatment of impaired fracture healing in patients with DM.

  Apr. 2020, Journal of orthopaedic surgery and research, 15(1) (1), 135 - 135, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The influence of adipose-derived stromal vascular fraction cells on the treatment of knee osteoarthritis.

  Masanori Tsubosaka, Tomoyuki Matsumoto, Satoshi Sobajima, Takehiko Matsushita, Hideki Iwaguro, Ryosuke Kuroda

  BACKGROUND: Adipose-derived stromal vascular fraction (SVF) cells are a mixed cell population that includes cells with multilineage potential, similar to bone marrow-derived mesenchymal stem cells. Our purpose is to investigate the influence of SVF cells in patients with knee osteoarthritis (OA) and the short-term treatment effects. METHODS: Fifty-seven patients were enrolled and treated with intra-articular injection of 2.5 × 107 SVF cells into the knee joint between September 2017 and March 2018. All patients were followed up for 12 months or longer. Mean age at treatment and follow-up period were 69.4 ± 6.9 years and 13.7 ± 2.0 months, respectively. The mean preoperative hip-knee-ankle angle was 6.7 ± 3.6°. SVF cells were prepared using the Celution®800/CRS system from the patients' abdominal or breech subcutaneous fat. The mean SVF cell viability was 90.6 ± 2.7%. Clinical evaluations were performed for range of motion, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual analog scale (VAS) for pain, and the Knee injury and Osteoarthritis Score (KOOS). Imaging evaluations, which included the hip-knee-ankle angle assessed via radiography, and T2 mapping value using a 1.5-T magnetic resonance imaging unit were also assessed. Both clinical and imaging evaluations were performed preoperatively, 1, 3, 6, and 12 months postoperatively, and compared among all timepoints (p < 0.05). RESULTS: Knee extension angle at 6 and 12 months postoperatively was significantly better than the preoperative angle. Total WOMAC, VAS, and KOOS scores at 1, 3, 6 and 12 months postoperatively were significantly better than preoperative scores. There was no significant difference in hip-knee-ankle angle among the five time periods. T2 mapping values of lateral femur and tibia were significantly higher 12 months postoperatively than preoperatively. CONCLUSIONS: The short-term clinical effects of intra-articular SVF cell injection on knee OA were excellent. Intra-articular SVF cell injection is a novel and innovative approach for treating patients with knee OA.

  Apr. 2020, BMC musculoskeletal disorders, 21(1) (1), 207 - 207, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A novel EWSR1-VGLL1 gene fusion in a soft tissue malignant myoepithelial tumor.

  Masato Komatsu, Teruya Kawamoto, Maki Kanzawa, Yohei Kawakami, Hitomi Hara, Toshihiro Akisue, Ryosuke Kuroda, Hayate Nakamura, Daisuke Hokka, Naoe Jimbo, Tomoo Itoh, Takanori Hirose

  Apr. 2020, Genes, chromosomes & cancer, 59(4) (4), 249 - 254, English, International magazine

  [Refereed]

  Scientific journal


• 三次元電磁気センサを使用した遠位橈尺関節不安定性の定量評価法の開発

  向原 伸太郎, 乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 吉川 智也, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O2 - 2, Japanese


• 粒子画像流速測定法による正中神経のエコー画像解析

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O3 - 4, Japanese


• 老化制御因子NMN(Nicotinamide Mononucleotide)の腱炎に対する抗炎症・酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O9 - 2, Japanese


• 手根管症候群の超音波画像に対するディープラーニング

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O62 - 1, Japanese


• 左坐骨結節裂離骨折の変形治癒後に坐骨神経障害を生じた1例

  井上 亜美, 橋本 慎吾, 高山 孝治, 黒田 雄一, 壺坂 正徳, 亀長 智幸, 高島 良典, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2020, JOSKAS, 45(2) (2), 344 - 345, Japanese

  Link to Kobe Univ. Repository (Kernel)


• TKA術後患者におけるKnee Society Score 2011患者満足度とその他の評価方法との比較

  立花 章太郎, 村津 裕嗣, 荒木 祥太郎, 平中 良明, 生田 健明, 大島 隆司, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2020, JOSKAS, 45(2) (2), 362 - 363, Japanese

  Link to Kobe Univ. Repository (Kernel)


• Medial preserving gap techniqueを用いたCR-TKAとPS-TKAの術後膝関節安定性の比較検討

  生田 健明, 村津 裕嗣, 荒木 祥太郎, 平中 良明, 立花 章太郎, 大島 隆司, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2020, JOSKAS, 45(2) (2), 366 - 367, Japanese

  Link to Kobe Univ. Repository (Kernel)


• 術前の開眼片脚立位バランス能力は、TKA術後の介護支援の予測に有用である

  立花 章太郎, 村津 裕嗣, 荒木 祥太郎, 平中 良明, 生田 健明, 大島 隆司, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2020, JOSKAS, 45(2) (2), 476 - 477, Japanese

  Link to Kobe Univ. Repository (Kernel)


• 単顆型人工膝関節置換術において術後の脛骨後方傾斜角が立位伸展角および最大伸展角に及ぼす影響

  平中 良明, 村津 裕嗣, 荒木 祥太郎, 立花 章太郎, 生田 健明, 大島 隆司, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2020, JOSKAS, 45(2) (2), 480 - 481, Japanese

  Link to Kobe Univ. Repository (Kernel)


• 三次元電磁気センサを使用した遠位橈尺関節不安定性の定量評価法の開発

  向原 伸太郎, 乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 吉川 智也, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O2 - 2, Japanese


• 粒子画像流速測定法による正中神経のエコー画像解析

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O3 - 4, Japanese


• 老化制御因子NMN(Nicotinamide Mononucleotide)の腱炎に対する抗炎症・酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O9 - 2, Japanese


• 手根管症候群の超音波画像に対するディープラーニング

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本手外科学会, Apr. 2020, 日本手外科学会雑誌, 37(1) (1), O62 - 1, Japanese


• 頸椎転移に対する後方手術成績と術後成績不良因子の検討

  神田 裕太郎, 角谷 賢一朗, 酒井 良忠, 張 鍾穎, 由留部 崇, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 81 - 81, Japanese


• 【半月板-Save the Meniscus】外側半月板の治療 外側半月板切除後急速軟骨破壊

  松下 雄彦, 黒田 良祐

  金原出版(株), Apr. 2020, 整形・災害外科, 63(5) (5), 621 - 623, Japanese


• 髄内釘のコンプレッション機構を利用し、自家骨移植なしで治療した上腕骨骨幹部偽関節の一例

  福本 弦太, 新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 271 - 271, Japanese


• 不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する

  平田 悠, 野村 和弘, 新倉 隆宏, 橘 吉寿, 加藤 大輔, 内山 奏, 福井 友章, 大江 啓介, 細岡 哲也, 和氣 弘明, 黒田 良祐, 小川 渉

  日本臨床分子医学会, Apr. 2020, 日本臨床分子医学会学術総会プログラム・抄録集, 57回, 58 - 58, Japanese


• 【整形外科の外傷治療-現状と課題-】その他のトピックにおける現状と課題 骨折治癒促進を目指した,臨床へとつなげる基礎研究

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (株)メジカルビュー社, Apr. 2020, 関節外科, 39(4月増刊) (4月増刊), 145 - 150, Japanese


• 大広範囲腱板断裂に対する大腿筋膜補強を併用した鏡視下腱板修復術

  国分 毅, 竹森 俊幸, 美舩 泰, 乾 淳幸, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 90 - 90, Japanese


• 骨粗鬆症外来における機械学習を用いた骨密度予測

  乾 淳幸, 西本 華子, 美舩 泰, 新倉 隆宏, 楊 鴻生, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 150 - 150, Japanese


• 高齢者肘関節脱臼に対してテープ付きアンカーを用いた靱帯修復を行なった一例

  元野 紘平, 乾 淳幸, 美舩 泰, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 206 - 206, Japanese


• Extraskeletal Para-articular Osteochondroma of the Ankle Joint in a Child: A Case Report

  Yohei Kawakami, Hitomi Hara, Teruya Kawamoto, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue

  Apr. 2020, JBJS case connector, 10(2) (2), e0274

  Scientific journal


• 前腕に発生した悪性グロームス腫瘍の1例

  北山 和道, 河本 旭哉, 原 仁美, 川上 洋平, 黒田 良祐, 秋末 敏宏

  (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 240 - 240, Japanese


• 半月板修復術の今までの限界と今後の可能性 スポーツ選手の半月板損傷

  松下 雄彦, 長井 寛斗, 中西 雄太, 荒木 大輔, 星野 祐一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 25 - 25, Japanese


• 高位脛骨骨切り術における術後立位・臥位での下肢アライメントの検討

  渡邉 秀, 松下 雄彦, 長井 寛斗, 荒木 大輔, 星野 祐一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 195 - 195, Japanese


• Treatment of Locking of the Metacarpophalangeal Joint of the Thumb.

  Yoshifumi Harada, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Takeshi Kokubu, Fujioka Hiroyuki, Ryosuke Kuroda

  Locking of the thumb metacarpophalangeal joint is a relatively rare condition. We report successful treatment in 11 cases of locking of the thumb. Ten patients were diagnosed at an average of 3.2 days (range: 0-21 days) from the injury onset, whereas one patient was diagnosed at 4 months from the injury. Seven of 11 cases underwent successful manual reduction, whereas the other four cases required surgical treatment. Among the surgically treated cases, all cases had a sharp prominent of the radial condyle of the metacarpal head. Therefore, this case series showed 1 chronic case and 4 of 10 cases with a nonround shape of metacarpal heads requiring open reduction.

  Apr. 2020, Journal of hand and microsurgery, 12(1) (1), 62 - 66, English, International magazine

  Scientific journal


• Recovery of activity level following total hip arthroplasty in patients less than 60 years of age.

  Kazuhiro Takeuchi, Shingo Hashimoto, Tomoyuki Matsumoto, Shinya Hayashi, Koji Takayama, Ryosuke Kuroda

  BACKGROUND: Total hip arthroplasty (THA) is a useful treatment for pain relief and functional improvement. THA indications now include younger, more active patients, with improved implant design and bearing materials. We aimed to investigate daily activity level and return to work after THA, about which limited information is available. Moreover, differences in patient background and clinical parameters including size of femoral head and surgical approach were evaluated. METHODS: A multicentre survey was carried out in patients below 60 years, undergoing THA between 2007 and 2012, at least 1 year after surgery. Primary THA patients with osteoarthritis, avascular necrosis, rheumatoid arthritis, hip dysplasia, and no history of postoperative complications were included. The questionnaire included daily activity and occupation levels before and after surgery. University of California, Los Angeles (UCLA) activity score and occupational classification index were defined, and statistical analysis was performed. RESULTS: The mean preoperative UCLA score in 204 patients was 4.55 which improved to 6.17 after surgery. Pre- as well as postoperative UCLA scores in males were significantly higher than that in females. No differences were observed in other parameters. Return to work rate in males was 94.4%; significantly higher than that in females (52.3%). Younger patients with large head THA were more likely to return to work. CONCLUSIONS: Most patients showed improved activity levels. Satisfaction levels were higher in young males with large femoral head size. Patients with a higher preoperative work level are expected to have a higher return to work rate.

  Mar. 2020, Hip international : the journal of clinical and experimental research on hip pathology and therapy, 31(5) (5), 1120700020911911 - 1120700020911911, English, International magazine

  Scientific journal


• Postoperative excessive anterior acetabular coverage is associated with decrease in range of motion after periacetabular osteotomy.

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Nao Shibanuma, Kazunari Ishida, Takahiro Niikura, Kotaro Nishida, Ryosuke Kuroda

  PURPOSE: The aim of this study was to evaluate the relationship between acetabular 3-dimensional (3D) alignment reorientation and clinical range of motion (ROM) after periacetabular osteotomy (PAO). METHODS: 50 patients (58 hips) with hip dysplasia participated in the study and underwent curved PAO. The pre- and postoperative 3D centre-edge (CE) angles and femoral anteversion were measured and compared with clinical outcomes, including postoperative ROM. RESULTS: The correlation between pre- and postoperative acetabular coverage and postoperative ROM was evaluated. Postoperative abduction and internal rotation ROM were significantly associated with postoperative lateral CE angles (abduction; p < 0.001, internal rotation; p = 0.028); flexion and internal rotation ROM was significantly associated with postoperative anterior CE angles (flexion; p < 0.001, internal rotation; p = 0.028). Femoral anteversion was negatively correlated with postoperative abduction (p = 0.017) and external rotation (p = 0.047) ROM. CONCLUSION: Postoperative anterior acetabular coverage may affect internal rotation ROM more than the lateral coverage. Therefore, the direction of acetabular reorientation should be carefully determined according to 3D alignment during PAO.

  Mar. 2020, Hip international : the journal of clinical and experimental research on hip pathology and therapy, 31(5) (5), 1120700020910370 - 1120700020910370, English, International magazine

  Scientific journal


• Transcutaneous carbon dioxide application inhibits muscle atrophy after fracture in rats.

  Miho Inoue, Yoshitada Sakai, Keisuke Oe, Takeshi Ueha, Takaaki Koga, Hanako Nishimoto, Shiho Akahane, Risa Harada, Sang Yang Lee, Takahiro Niikura, Ryosuke Kuroda

  BACKGROUND: Muscle atrophy causes difficulty in resuming daily activities after a fracture. Because transcutaneous carbon dioxide (CO2) application has previously upregulated oxygen pressure in the local tissue, thereby demonstrating its potential in preventing muscle atrophy, here we investigated effects of CO2 application on muscle atrophy after femoral shaft fracture. METHODS: Thirty fracture model rats were produced and randomly divided into a no treatment (control group) and treatment (CO2 group) groups. After treatment, the soleus muscle was dissected at post-fracture days 0, 14, and 21. Evaluations were performed by measuring muscle weight and performing histological examination and gene expression analysis. RESULTS: Muscle weight was significantly higher in the CO2 group than in the control group. Histological analysis revealed that the muscle fiber cross-sectional area was reduced in both groups. Nevertheless, the extent of atrophy was lesser in the CO2 group. Muscle fibers in the control group tended to change into fast muscle fibers. Vascular staining revealed that more capillary vessels surrounded the muscle fibers in the CO2 group than in the control group. Messenger RNA (mRNA) analysis revealed that the CO2 group had a significantly enhanced expression of genes that were related to muscle synthesis. CONCLUSION: Transcutaneous CO2 application may be a novel therapeutic strategy for preventing skeletal muscle atrophy after fracture.

  Mar. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(2) (2), 338 - 343, English, Domestic magazine

  [Refereed]

  Scientific journal


• Assessment of posterior shoulder muscle stiffness related to posterior shoulder tightness in college baseball players using shear wave elastography.

  Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takeshi Kataoka, Takashi Kurosawa, Kohei Yamaura, Shintaro Mukohara, Takahiro Niikura, Takeshi Kokubu, Toshihiro Akisue, Ryosuke Kuroda

  BACKGROUND: Limitations of shoulder range of motion (ROM) have been reported to be at high risk for shoulder disorders in baseball players. In this study, we assessed posterior shoulder muscle stiffness using shear wave elastography in baseball players with and without posterior shoulder tightness. MATERIALS AND METHODS: In total, 21 college baseball players volunteered to participate in this study. Passive ROMs for shoulder abduction and horizontal adduction were measured using a goniometer. Subsequently, we divided all participants into 2 groups based on the differences between bilateral shoulder ROMs: STIFF+ and STIFF- groups. Thickness and elasticity of the posterior and inferior shoulder muscles were assessed using ultrasound. RESULTS: Shoulder abduction ROM on the throwing side was 114.5° ± 5.3° and 131.3° ± 5.7° in the STIFF+ and STIFF- groups, respectively, which was significantly different between the 2 groups (P = .023). Horizontal adduction ROM on the throwing side was 96.6° ± 4.9° and 110.9° ± 4.8° in the STIFF+ and STIFF- groups, respectively, which was also significantly different between the 2 groups (P = .014). The elasticity of infraspinatus and lower trapezius in the STIFF+ group was significantly greater than that in the STIFF- group (P = .018 and .033, respectively). DISCUSSION: In this study, we found that the elasticity of infraspinatus and lower trapezius in stiff shoulders was significantly greater than that in nonstiff shoulders, which indicated that the infraspinatus and lower trapezius could be the key muscles in posterior shoulder tightness.

  Mar. 2020, Journal of shoulder and elbow surgery, 29(3) (3), 571 - 577, English, International magazine

  [Refereed]

  Scientific journal


• 外傷診療におけるCAOSの応用 難治骨折治療における3D実寸大骨モデルの応用

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  日本CAOS研究会・日本最小侵襲整形外科学会, Mar. 2020, 日本CAOS研究会・日本最小侵襲整形外科学会プログラム・抄録集, 14回・26回, 72 - 72, Japanese


• 炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる 臨床試験の報告

  新倉 隆宏, 岩倉 崇, 李 相亮, 大江 啓介, 福井 友章, 酒井 良忠, 秋末 敏宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1040 - S1040, Japanese


• 整形外科専門医研修プログラムの抱える問題点 神戸大学整形外科専門研修プログラムの現状と課題

  松本 知之, 美舩 泰, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S644 - S644, Japanese


• 糖尿病性腱障害モデルに対するアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 浩幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1115 - S1115, Japanese


• 頸椎転移の手術成績と成績不良因子の検討

  神田 裕太郎, 角谷 賢一朗, 酒井 良忠, 張 鍾穎, 由留部 崇, 垣内 裕司, 武岡 由樹, 辻本 龍, 宮崎 邦彦, 高田 徹, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1096 - S1096, Japanese


• 転移性頸椎腫瘍に対する後方手術成績と術後成績不良因子の検討

  神田 裕太郎, 角谷 賢一朗, 酒井 良忠, 張 鍾穎, 由留部 崇, 垣内 裕司, 武岡 由樹, 辻本 龍, 宮崎 邦彦, 宮崎 真吾, 高田 徹, 黒田 良祐

  (一社)日本脊椎脊髄病学会, Mar. 2020, Journal of Spine Research, 11(3) (3), 221 - 221, Japanese


• 健側膝における脛骨後方傾斜角が立位膝側面アライメントに及ぼす影響 前十字靱帯損傷症例と半月損傷症例の比較

  平中 良明, 村津 裕嗣, 荒木 祥太郎, 立花 章太郎, 生田 健明, 大島 隆司, 松本 知之, 松下 雄彦, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2020, JOSKAS, 45(1) (1), 68 - 69, Japanese


• 膝前十字靱帯再建の過去・現在・未来

  黒田 良祐, 松下 雄彦, 星野 祐一

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(2) (2), S21 - S21, Japanese


• 骨延長術における炭酸ガス経皮吸収の骨形成促進効果

  隈部 洋平, 新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  日本創外固定・骨延長学会, Mar. 2020, 日本創外固定・骨延長学会雑誌, 31, 352 - 352, Japanese


• 膝・肩関節 Unstable painful shoulder(UPS)に対して鏡視下手術を行った1例

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  関西関節鏡・膝研究会, Mar. 2020, 関西関節鏡・膝研究会プログラム・演題抄録, 32回, 25 - 25, Japanese


• 機械学習による骨粗鬆症外来での骨折リスク予測の試み

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S642 - S642, Japanese


• Shear wave elastographyを用いた投球動作による前腕屈筋群の組織弾性変化についての検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 国分 毅, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S702 - S702, Japanese


• 超音波検査を用いた手根管症候群における母指球筋の術後変化

  名倉 一成, 金谷 貴子, 原田 義文, 高瀬 史明, 乾 淳幸, 美舩 泰, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S822 - S822, Japanese


• 高血糖誘導酸化ストレスを与えた腱細胞に対するDHEAの効果

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S836 - S836, Japanese


• 老化制御因子NMN(nicotinamide mononucleotide)の腱炎に対する抗炎症・酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S837 - S837, Japanese


• ディープラーニングによる手根管症候群のエコー画像診断

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 吉川 智也, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1075 - S1075, Japanese


• 治療薬別のtrabecular bone score(TBS)値およびbone mineral density(BMD)値の2年間の推移

  西本 華子, 乾 淳幸, 美舩 泰, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 吉川 智也, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1146 - S1146, Japanese


• プロ野球投手におけるglenohumeral internal rotation deficit(GIRD)に関連する因子の検討

  美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 吉川 智也, 国分 毅, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1258 - S1258, Japanese


• 膝関節 骨端線閉鎖前のACL損傷膝に対するTibial Tunnelを作成しないSBによるPhyseal-Sparing Techniquesを用いた2症例の治療成績

  森 昭嘉, 星野 祐一, 抽冬 晃司, 渡邊 秀, 中西 雄太, 山本 哲也, 山下 貴大, 長井 寛斗, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  関西関節鏡・膝研究会, Mar. 2020, 関西関節鏡・膝研究会プログラム・演題抄録, 32回, 21 - 21, Japanese


• Patellofemoral Instability-Case-based discussion 内側膝蓋大腿靱帯再建術を中心とした治療

  松下 雄彦, 星野 祐一, 荒木 大輔, 長井 寛斗, 渡邊 秀, 神崎 至幸, 黒田 良祐

  関西関節鏡・膝研究会, Mar. 2020, 関西関節鏡・膝研究会プログラム・演題抄録, 32回, 32 - 32, Japanese


• 造影CTによる高位脛骨骨切り術と脛骨粗面下骨切り術における膝窩動脈損傷のリスク評価

  森 昭嘉, 松下 雄彦, 抽冬 晃司, 渡邊 秀, 中西 雄太, 山本 哲也, 山下 貴大, 長井 寛斗, 荒木 大輔, 神崎 至幸, 星野 祐一, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(2) (2), S322 - S322, Japanese


• 半月板損傷のバイオメカニクスupdate 半月板損傷がACL損傷・再建膝のバイオメカニクスに及ぼす影響

  星野 祐一, 長井 寛斗, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(2) (2), S405 - S405, Japanese


• 足関節・足部疾患に対する鏡視下手術の最先端 後足部疾患に対する後足部内視鏡手術の最先端

  神崎 至幸, 抽冬 晃司, 山本 哲也, 山下 貴大, 茨木 一行, 長井 寛斗, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(2) (2), S465 - S465, Japanese


• わが国の人工足関節置換術の治療戦略-2020- Combined TAA人工足関節の実際

  神崎 至幸, 抽冬 晃司, 山本 哲也, 山下 貴大, 茨木 一行, 長井 寛斗, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(2) (2), S473 - S473, Japanese


• 3DMRIによる足関節外側靱帯損傷術前後の踵腓靱帯の画像評価に対する検者間信頼性の検討

  抽冬 晃司, 星野 祐一, 神崎 至幸, 山本 哲也, 山下 貴大, 茨木 一行, 長井 寛斗, 荒木 大輔, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S738 - S738, Japanese


• 重度の内反動揺性を伴う足関節不安定症に対する鏡視下外側靱帯修復術の治療成績

  山下 貴大, 神崎 至幸, 抽冬 晃司, 山本 哲也, 茨木 一行, 長井 寛斗, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S952 - S952, Japanese


• 人工距骨併用人工足関節置換術後の踵骨および舟状骨における骨嚢胞性変化

  茨木 一行, 神崎 至幸, 抽冬 晃司, 山本 哲也, 山下 貴大, 長井 寛斗, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1062 - S1062, Japanese


• 変形性足関節症の病期分類と人工足関節置換術後の臨床成績の関係

  抽冬 晃司, 神崎 至幸, 山本 哲也, 山下 貴大, 茨木 一行, 長井 寛斗, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1062 - S1062, Japanese


• 当科における人工足関節置換術(TAA)と人工距骨併用人工足関節置換術(combined TAA)の治療成績の比較

  山本 哲也, 神崎 至幸, 抽冬 晃司, 山下 貴大, 茨木 一行, 長井 寛斗, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1063 - S1063, Japanese


• 人工足関節置換術(TAA)による荷重軸の変化について

  山下 貴大, 神崎 至幸, 抽冬 晃司, 山本 哲也, 茨木 一行, 長井 寛斗, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1188 - S1188, Japanese


• 炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる 臨床試験の報告

  新倉 隆宏, 岩倉 崇, 李 相亮, 大江 啓介, 福井 友章, 酒井 良忠, 秋末 敏宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1040 - S1040, Japanese

  [Refereed]


• Improved bone bonding of hydroxyapatite spacers with a high porosity in a quantitative computed tomography-image pixel analysis: A prospective 1-year comparative study of the consecutive cohort undergoing double-door cervical laminoplasty.

  Yoshiki Takeoka, Takashi Yurube, Koichiro Maeno, Yutaro Kanda, Ryu Tsujimoto, Kunihiko Miyazaki, Yuji Kakiuchi, Shingo Miyazaki, Zhongying Zhang, Toru Takada, Kotaro Nishida, Minoru Doita, Ryosuke Kuroda, Kenichiro Kakutani

  Laminoplasty using hydroxyapatite (HA) spacers is widely performed in patients with cervical myelopathy. However, spacer dislocation is a critical complication caused by bone absorption and inadequate bone conductivity, and can result in dural damage and restenosis. We thus designed a prospective cohort study to clarify the feasibility of increased porosity HA spacers for double-door laminoplasty by analyzing computed tomography (CT) images. Forty-seven patients underwent cervical laminoplasty. Two different types of CERATITE HA spacer were used, either high porosity (50%) or low porosity (35%). These HA spacers were placed in an alternating manner into the laminae in each patient. In total, 85 high-porosity (50%) HA spacers and 84 low-porosity (35%) HA spacers were implanted. At postoperative 2 weeks, 3 months, 6 months, and 1 year, CT images were obtained. In both groups, the percentage of bone-bonding boundary area of the HA spacer in contact with laminae and bone volume of the spinous process relative to the 2-week value were calculated by a 3D and 2D CT-image pixel analysis. The bone-bonding ratio was significantly higher in high-porosity (50%) than low-porosity (35%) HA spacers at 3 months and thereafter (1 year, 69.3 ± 27.8% and 49.7 ± 32.9% respectively, P < .01). The bone volume in both groups significantly decreased with time (1 year, 73.2 ± 29.8% and 69.0 ± 30.4% respectively, P < .01), indicating bone absorption. This showed no significant difference between the HA spacers (P = .15) but was higher in high-porosity (50%) than low-porosity (35%) HA spacers throughout the study period. Meanwhile, spacer breakage was found in 4.7% of high-porosity (50%) HA spacers and 1.2% of low-porosity (35%) HA spacers (P = .37). In summary, high-porosity (50%) HA spacers have the advantages of accelerated bone bonding and relatively decelerated bone absorption compared to low-porosity (35%) HA spacers; however, possibly more frequent breakage of HA spacers with a high porosity (50%) requires careful, extended postoperative follow-up.

  Mar. 2020, JOR spine, 3(1) (1), e1080, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Autophagy and mTOR signaling during intervertebral disc aging and degeneration.

  Takashi Yurube, Masaaki Ito, Yuji Kakiuchi, Ryosuke Kuroda, Kenichiro Kakutani

  Degenerative disc disease is a highly prevalent, global health problem that represents the primary cause of back pain and is associated with neurological disorders, including radiculopathy, myelopathy, and paralysis, resulting in worker disability and socioeconomic burdens. The intervertebral disc is the largest avascular organ in the body, and degeneration is suspected to be linked to nutritional deficiencies. Autophagy, the process through which cells self-digest and recycle damaged components, is an important cell survival mechanism under stress conditions, especially nutrient deprivation. Autophagy is negatively controlled by the mammalian target of rapamycin (mTOR) signaling pathway. mTOR is a serine/threonine kinase that detects nutrient availability to trigger the activation of cell growth and protein synthesis pathways. Thus, resident disc cells may utilize autophagy and mTOR signaling to cope with harsh low-nutrient conditions, such as low glucose, low oxygen, and low pH. We performed rabbit and human disc cell and tissue studies to elucidate the involvement and roles played by autophagy and mTOR signaling in the intervertebral disc. In vitro serum and nutrient deprivation studies resulted in decreased disc cell proliferation and metabolic activity and increased apoptosis and senescence, in addition to increased autophagy. The selective RNA interference-mediated and pharmacological inhibition of mTOR complex 1 (mTORC1) was protective against inflammation-induced disc cellular apoptosis, senescence, and extracellular matrix catabolism, through the induction of autophagy and the activation of the Akt-signaling network. Although temsirolimus, a rapamycin derivative with improved water solubility, was the most effective mTORC1 inhibitor tested, dual mTOR inhibitors, capable of blocking multiple mTOR complexes, did not rescue disc cells. In vivo, high levels of mTOR-signaling molecule expression and phosphorylation were observed in human intermediately degenerated discs and decreased with age. A mechanistic understanding of autophagy and mTOR signaling can provide a basis for the development of biological therapies to treat degenerative disc disease.

  Mar. 2020, JOR spine, 3(1) (1), e1082, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Reduced nucleotomy-induced intervertebral disc disruption through spontaneous spheroid formation by the Low Adhesive Scaffold Collagen (LASCol).

  Yoshiki Takeoka, Takashi Yurube, Koichi Morimoto, Saori Kunii, Yutaro Kanda, Ryu Tsujimoto, Yohei Kawakami, Naomasa Fukase, Toshiyuki Takemori, Kaoru Omae, Yuji Kakiuchi, Shingo Miyazaki, Kenichiro Kakutani, Toru Takada, Kotaro Nishida, Masanori Fukushima, Ryosuke Kuroda

  Back pain is a global health problem with a high morbidity and socioeconomic burden. Intervertebral disc herniation and degeneration are its primary cause, further associated with neurological radiculopathy, myelopathy, and paralysis. The current surgical treatment is principally discectomy, resulting in the loss of spinal movement and shock absorption. Therefore, the development of disc regenerative therapies is essential. Here we show reduced disc damage by a new collagen type I-based scaffold through actinidain hydrolysis-Low Adhesive Scaffold Collagen (LASCol)-with a high 3D spheroid-forming capability, water-solubility, and biodegradability and low antigenicity. In human disc nucleus pulposus and annulus fibrosus cells surgically obtained, time-dependent spheroid formation with increased expression of phenotypic markers and matrix components was observed on LASCol but not atelocollagen (AC). In a rat tail nucleotomy model, LASCol-injected and AC-injected discs presented relatively similar radiographic and MRI damage control; however, LASCol, distinct from AC, decelerated histological disc disruption, showing collagen type I-comprising LASCol degradation, aggrecan-positive and collagen type II-positive endogenous cell migration, and M1-polarized and also M2-polarized macrophage infiltration. Reduced nucleotomy-induced disc disruption through spontaneous spheroid formation by LASCol warrants further investigations of whether it may be an effective treatment without stem cells and/or growth factors for intervertebral disc disease.

  Mar. 2020, Biomaterials, 235, 119781 - 119781, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Rotatory Knee Laxity Exists on a Continuum in Anterior Cruciate Ligament Injury.

  Jayson Lian, Theresa Diermeier, Mitchell Meghpara, Adam Popchak, Clair N Smith, Ryosuke Kuroda, Stefano Zaffagnini, Kristian Samuelsson, Jón Karlsson, James J Irrgang, Volker Musahl

  BACKGROUND: The purpose of this investigation was to compare the magnitude of rotatory knee laxity in patients with a partial anterior cruciate ligament (ACL) tear, those with a complete ACL tear, and those who had undergone a failed ACL reconstruction. It was hypothesized that rotatory knee laxity would increase with increasing injury grade, with knees with partial ACL tears demonstrating the lowest rotatory laxity and knees that had undergone failed ACL reconstruction demonstrating the highest rotatory laxity. METHODS: A prospective multicenter study cohort of 354 patients who had undergone ACL reconstruction between 2012 and 2018 was examined. All patients had both injured and contralateral healthy knees evaluated using standardized, preoperative quantitative pivot shift testing, determined by a validated, image-based tablet software application and a surface-mounted accelerometer. Quantitative pivot shift was compared with the contralateral healthy knee in 20 patients with partial ACL tears, 257 patients with complete ACL tears, and 27 patients who had undergone a failed ACL reconstruction. Comparisons were made using 1-way analysis of variance (ANOVA) with post hoc 2-sample t tests with Bonferroni correction. Significance was set at p < 0.05. RESULTS: There were stepwise increases in side-to-side differences in quantitative pivot shift in terms of lateral knee compartment translation for patients with partial ACL tears (mean [and standard deviation], 1.4 ± 1.5 mm), those with complete ACL tears (2.5 ± 2.1 mm), and those who had undergone failed ACL reconstruction (3.3 ± 1.9 mm) (p = 0.01) and increases in terms of lateral compartment acceleration for patients with partial ACL tears (0.7 ± 1.4 m/s), those with complete ACL tears (2.3 ± 3.1 m/s), and those who had undergone failed ACL reconstruction (2.4 ± 5.5 m/s) (p = 0.01). A significant difference in lateral knee compartment translation was found when comparing patients with partial ACL tears and those with complete ACL tears (1.2 ± 2.1 mm [95% confidence interval (CI), 0.2 to 2.1 mm]; p = 0.02) and patients with partial ACL tears and those who had undergone failed ACL reconstruction (1.9 ± 1.7 mm [95% CI, 0.8 to 2.9 mm]; p = 0.001), but not when comparing patients with complete ACL tears and those who had undergone failed ACL reconstruction (0.8 ± 2.1 [95% CI, -0.1 to 1.6 mm]; p = 0.09). Increased lateral compartment acceleration was found when comparing patients with partial ACL tears and those with complete ACL tears (1.5 ± 3.0 m/s [95% CI, 0.8 to 2.3 m/s]; p = 0.0002), but not when comparing patients with complete ACL tears and those who had undergone failed ACL reconstruction (0.1 ± 3.4 m/s [95% CI, -2.2 to 2.4 m/s]; p = 0.93) or patients with partial ACL tears and those who had undergone failed ACL reconstruction (1.7 ± 4.2 m/s [95% CI, -0.7 to 4.0 m/s]; p = 0.16). An increasing lateral compartment translation of the contralateral, ACL-healthy knee was found in patients with partial ACL tears (0.8 mm), those with complete ACL tears (1.2 mm), and those who had undergone failed ACL reconstruction (1.7 mm) (p < 0.05). CONCLUSIONS: A progressive increase in rotatory knee laxity, defined by side-to-side differences in quantitative pivot shift, was observed in patients with partial ACL tears, those with complete ACL tears, and those who had undergone failed ACL reconstruction. These results may be helpful when assessing outcomes and considering indications for the management of high-grade rotatory knee laxity. LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

  Feb. 2020, The Journal of bone and joint surgery. American volume, 102(3) (3), 213 - 220, English, International magazine

  Scientific journal


• No difference in postoperative rotational laxity after ACL reconstruction in patients with and without anterolateral capsule injury: quantitative evaluation of the pivot-shift test at 1-year follow-up.

  Yuji Hiroshima, Yuichi Hoshino, Nobuaki Miyaji, Toshikazu Tanaka, Daisuke Araki, Noriyuki Kanzaki, Takehiko Matsushita, Ryosuke Kuroda

  PURPOSE: To compare rotational laxity in anterior cruciate ligament (ACL)-reconstructed knees retrospectively with and without concomitant anterolateral capsule (ALC) injury confirmed by magnetic resonance imaging (MRI) prior to ACL reconstruction. METHODS: Sixty-two ACL-reconstructed knees (26 men, 36 women; median age 20 (range 13-59)) were included. Pivot-shift test was performed before ACL reconstruction and 1 year postoperatively under anesthesia with both clinical grading and quantitative measurement simultaneously. Clinical grading was determined according to the International Knee Documentation Committee (IKDC) criteria (none, glide, clunk, or gross), and an electromagnetic measurement system was used to provide tibial acceleration as a quantitative parameter. The resence of concomitant ALC injury was confirmed retrospectively by MRI. The pivot-shift test was compared between ACL-reconstructed knees with and without ALC injury test for clinical grading and the independent t test for quantitative evaluation. RESULTS: ALC injury was identified in 26 of 62 (42%) knees. Before ACL reconstruction, there was no difference in the pivot-shift test results between the ACL-deficient knees with and without ALC injury in IKDC grading (n.s.) or tibial acceleration (1.1 ± 0.7 m/s2 and 1.4 ± 1.1 m/s2, respectively, n.s.). At 1 year postoperatively, no difference was observed between groups (IKDC, p = 0.90; tibial acceleration, 0.6 ± 0.3 m/s2 and 0.8 ± 0.6 m/s2, n.s.). CONCLUSIONS: Concomitant ALC injury at the time of ACL injury had no effect on the rotational laxity of the knee in the postoperative course after ACL reconstruction. Therefore, additional treatment for ALC injury may not be warranted. LEVEL OF EVIDENCE: IV.

  Feb. 2020, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 28(2) (2), 489 - 494, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Influence of Narrow Femoral Implants on Intraoperative Soft Tissue Balance in Posterior-Stabilized Total Knee Arthroplasty.

  Kazunari Ishida, Nao Shibanuma, Hiroshi Sasaki, Koji Takayama, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: Narrow femoral implants were developed to improve fit and prevent overhang in primary total knee arthroplasty (TKA). We compared intraoperative soft tissue balance between standard and narrow implants in posterior-stabilized (PS) TKA. METHODS: We enrolled 30 consecutive patients with varus osteoarthritis undergoing PS TKA using an image-free navigation system. Standard and narrow femoral trial implants were inserted, and their soft tissue balance was measured. Subgroup analysis, based on the actual implanted femoral implant, was performed to assess the influence of narrow implants on soft tissue balance. RESULTS: Narrow trial group had significantly larger joint component gaps than standard trial group at all measured flexion angles, except at 60° (P < .05). For the standard implant cohort, narrow trial group had significantly larger joint component gaps than standard trial group at 30°, 120°, and 135° flexion (P < .05). For the narrow implant cohort, narrow trial group had significantly larger joint component gaps than standard trial group at all measured flexion angles, except at 0° and 60° (P < .05). Narrow trial group had significantly larger varus ligament balance than standard trial group at 45° and 60° flexion (P < .05). The varus angles for standard implants were comparable between groups; however, narrow trial group had significantly larger varus angles for narrow implants than standard trial group at 45°, 60°, and 120° flexion (P < .05). CONCLUSION: The medial-lateral dimension and volume of the femoral component may influence intraoperative soft tissue balance in PS TKA. The effects may be greater when narrow implants are selected to avoid component overhang.

  Feb. 2020, The Journal of arthroplasty, 35(2) (2), 388 - 393, English, International magazine

  [Refereed]

  Scientific journal


• Inhibition of Knee Osteoarthritis Progression in Mice by Administering SRT2014, an Activator of Silent Information Regulator 2 Ortholog 1.

  Nobuaki Miyaji, Kyohei Nishida, Toshikazu Tanaka, Daisuke Araki, Noriyuki Kanzaki, Yuichi Hoshino, Ryosuke Kuroda, Takehiko Matsushita

  OBJECTIVE: Previous findings suggest that silent information regulator 2 ortholog 1 (SIRT1) plays essential roles in chondrocytes and prevents osteoarthritis (OA) development. The purpose of this study was to investigate the effects of intraperitoneal (i.p.) and intra-articular (i.a.) administration of the SIRT1 activator SRT2104, which has been approved for use in humans. DESIGN: OA was induced by destabilizing the medial meniscus in the knee joint of 12-week-old CL57BL/6J mice. The mice were divided into 3 groups, that is, the control group, SRT2104 i.p.-injection group, and SRT2104 i.a.-injection group. Tissues were harvested at 4, 8, 12, and 16 weeks postsurgery. OA progression was evaluated using the Osteoarthritis Research Society International (OARSI) score. The production of OA-related proteins in cartilage and synovium was examined by immunohistochemistry. RESULTS: OARSI scores in the control group were significantly higher at 8 and 12 weeks compared with other 2 groups. Immunohistochemical analysis showed that Sirt1 and type-2 collagen significantly increased, whereas MMP-13, ADAMTS-5, IL-1β, IL-6, cleaved caspase 3, PARP p85, acetylated NF-κB p65, and iNOS decreased significantly in cartilage tissues from the i.p. and i.a, SRT2104 groups. In the synovium, more iNOS-positive M1-like macrophages were observed in the control group than in the i.p. and i.a, SRT2104 groups, whereas more CD206-positive M2-like macrophages were detected in the i.p. and i.a. SRT2104 groups. CONCLUSIONS: Both i.p. and i.a. SRT2104 injection reduced OA progression in the mouse OA model, suggesting that SRT2104 can serve as a new treatment for OA.

  Jan. 2020, Cartilage, 1947603519900795 - 1947603519900795, English, International magazine

  [Refereed]

  Scientific journal


• Isolated Nerve Grafting for a Young Patient with a Complete Common Peroneal Nerve Palsy Following a Traumatic Knee Dislocation: A case report.

  Shintaro Mukohara, Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Takeshi Kataoka, Takashi Kurosawa, Kohei Yamaura, Ryosuke Kuroda

  BACKGROUND: Common peroneal nerve (CPN) injury following a knee dislocation is a serious problem, and an optimal treatment is yet to be established. We report a case of complete CPN palsy following a knee dislocation treated with sural nerve grafting. CASE: A 19-year-old man suffered a knee injury during a hurdle race. Diagnosis in a previous hospital revealed a complex ligament injury with CPN palsy. Ten weeks following injury, he was admitted to our institution because of a lack of neurological improvement. Considering the grade 0 results obtained in the manual muscle test (MMT) of tibialis anterior (TA) and extensor hallucis longus (EHL), the patient was diagnosed with complete neurotmesis of CPN, and surgery was performed. Operative findings revealed CPN discontinuity and an extended nerve defect length of 15 cm; therefore, sural nerve grafting was performed to repair the CPN injury. One year postoperatively, a grade 1 result from MMT of TA and EHL indicated a gradual neurological recovery. Three years postoperatively, MMT of TA and EHL showed significant improvement to grade 4+ and grade 4, respectively, and he could walk and jog without a knee brace. DISCUSSION: Nerve graft length of >6 cm has shown limited success, and their efficacy for the treatment of CPN palsy following knee dislocations is controversial. However, young patients with complete CPN lesion are more likely to recover regardless of the length of nerve injury. Therefore, in such cases, nerve grafting can be considered as one of the treatments for complete CPN lesion following knee dislocations.

  Jan. 2020, The Kobe journal of medical sciences, 65(3) (3), E110-E113, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Spinal Subarachnoid Hematoma After Cerebrospinal Fluid Drainage in Thoracoabdominal Aortic Aneurysm Repair: Case Report and Literature Review.

  Kohei Kuroshima, Takahiro Waki, Aritetsu Kanemura, Kenjiro Ito, Ryosuke Kuroda

  BACKGROUND: Cerebrospinal fluid (CSF) drainage reduces the risk of paraplegia in thoracoabdominal aortic aneurysm (TAAA) repair. Intracranial hemorrhage after TAAA repair has been reported as a rare complication of CSF drainage; however, spinal subarachnoid hematoma has never been reported. Here, we present a case of lumbosacral subarachnoid hematoma after CSF drainage in TAAA repair. CASE DESCRIPTION: The patient was a 76-year-old man who was hospitalized for TAAA repair. Just before the operation, a CSF drainage catheter was inserted into the L4/5 vertebral interspace. Continuous CSF drainage was performed during the operation. The CSF drain was clamped just after the operation, and the drainage catheters were removed at 24 hours after the operation. On postoperative day 1, the patient experienced pain and paralysis in both lower limbs that worsened over time. Magnetic resonance imaging of the brain and spinal cord was indicative of a spinal subarachnoid hematoma. Removal of hematoma with thoracolumbar and lumbosacral laminectomy was performed, and immediately after the surgery, the pain and paralysis in both lower limbs improved. Six months after the removal of the hematoma, the paralysis in both lower limbs completely resolved and the patient achieved the preinjury activity level. CONCLUSIONS: We present a rare case of lumbosacral subarachnoid hematoma after CSF drainage in TAAA repair. We should consider spinal subarachnoid hematoma when paralysis in the lower limbs occurs after CSF drainage.

  Jan. 2020, World neurosurgery, 133, 188 - 191, English, International magazine

  [Refereed]

  Scientific journal


• Optimal injection depth for collagenase clostridium histolyticum determined by ultrasonography in the treatment of dupuytren’s disease

  I. Nagura, T. Kanatani, Y. Harada, A. Inui, Y. Mifune, R. Kuroda, S. Lucchina

  Czech Medical Association J.E. Purkyne, 2020, Acta Chirurgiae Plasticae, 62(3-4) (3-4), 64 - 67, English

  Scientific journal


• Evaluation of apocynin in vitro on high glucose-induced oxidative stress on tenocytes

  T. Kurosawa, Y. Mifune, A. Inui, H. Nishimoto, Y. Ueda, T. Kataoka, K. Yamaura, S. Mukohara, R. Kuroda

  British Editorial Society of Bone and Joint Surgery, 2020, Bone and Joint Research, 9(1) (1), 23 - 28, English

  Scientific journal


• スポーツ選手における半月板単独損傷に対する半月板縫合術の治療成績

  中西 雄太, 長井 寛斗, 松下 雄彦, 荒木 大輔, 星野 祐一, 神崎 至幸, 黒田 良祐

  スポーツ傷害フォーラム, 2020, スポーツ傷害, 25, 38 - 38, Japanese


• 半月板損傷治療の最前線 内側半月板損傷

  松下 雄彦, 長井 寛斗, 中西 雄太, 荒木 大輔, 星野 祐一, 神崎 至幸, 黒田 良祐

  スポーツ傷害フォーラム, 2020, スポーツ傷害, 25, 43 - 43, Japanese


• 健常成人における男性と女性の静止時及び歩行時の足底圧の評価 In shoe systemを用いた解析

  宮平 桐佑, 山本 哲也, 星野 祐一, 神崎 至幸, 山田 真, 長宗 高樹, 長井 寛斗, 荒木 大輔, 松下 雄彦, 黒田 良祐, 東 千夏, 西田 康太郎

  琉球医学会, 2020, 琉球医学会誌, 39(1-4) (1-4), 94 - 94, Japanese


• Sequential changes in lower extremity function after total knee arthroplasty

  Masanori Tsubosaka, Hirotsugu Muratsu, Naoki Nakano, Tomoyuki Kamenaga, Yuichi Kuroda, Hidetoshi Miya, Ryosuke Kuroda, Tomoyuki Matsumoto

  2020, Journal of Orthopaedic Surgery, 28(3) (3)

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 健常成人における男性と女性の静止時及び歩行時の足底圧の評価 In shoe systemを用いた解析

  宮平 桐佑, 山本 哲也, 星野 祐一, 神崎 至幸, 山田 真, 長宗 高樹, 長井 寛斗, 荒木 大輔, 松下 雄彦, 黒田 良祐, 東 千夏, 西田 康太郎

  琉球医学会, 2020, 琉球医学会誌, 39(1-4) (1-4), 94 - 94, Japanese


• 右肘関節開放脱臼骨折に合併したMycobacterium fortuitum感染症の1例

  村尾 仁美, 乾 淳幸, 西本 華子, 美舩 泰, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Jan. 2020, 中部日本整形外科災害外科学会雑誌, 63(1) (1), 121 - 122, Japanese


• Sciatic Nerve Palsy following Curved Periacetabular Osteotomy.

  Masahiro Fujita, Shinya Hayashi, Kenichi Kikuchi, Yoshinori Takashima, Tomoyuki Kamenaga, Masanori Tsubosaka, Koji Fukuda, Koji Takayama, Shingo Hashimoto, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Curved periacetabular osteotomy (CPO) is used for the treatment of dysplastic hips. Previous studies have reported satisfying outcomes and low rate of severe complications associated with this procedure; however, no case of postoperative sciatic nerve palsy has been reported. In this study, we describe a case of postoperative sciatic nerve palsy following CPO due to nerve strangulation by scar tissue without direct injury. A female patient had severe buttock pain and posterior leg numbness after she underwent left-side CPO. Postoperative magnetic resonance imaging showed that the sciatic nerve was strangulated by the surrounding soft tissue. There was no bone fragment, active infection, bone necrosis, tumor, or spine disease. Therefore, we diagnosed nerve palsy by soft tissue strangulation, and revision surgery was indicated. During revision surgery, the sciatic nerve was observed to be strangulated by the scarring soft tissue, and the nerve had no mobility. After detachment, the pain and numbness disappeared. Direct injury of the sciatic nerve should not be caused by CPO; however, there is a possibility of postoperative sciatic nerve palsy due to the scarring soft tissue. Early diagnosis and appropriate treatment are important for optimal postoperative clinical outcomes.

  2020, Case reports in orthopedics, 2020, 8569285 - 8569285, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Limb Salvage for a Mangled Foot: A Case Report.

  Takahiro Oda, Keisuke Oe, Atsushi Sakurai, Tomoaki Fukui, Takahiro Niikura, Ryosuke Kuroda

  Introduction: It remains controversial whether amputation or limb salvage is the best approach for mangled foot cases because there are no clear criteria for treatment. We report a case of successful limb salvage for a mangled foot, with good outcomes. Case Report: The patient was a 30-year-old man who sustained a crush injury to his left foot and ankle and lower legs in a car crash; he had severe open left foot and ankle fracture and bilateral open tibial shaft fractures. Blood flow was maintained by the posterior tibial artery, and the tibial nerve was intact. We stabilized the ankle using Kirschner wires on the day of injury. Plastic surgeons were consulted for early soft tissue coverage. Final fixation was performed 12 weeks after flap grafting; we grafted an autologous bone on the defect, according to the Masquelet technique. Four months after the final surgery, fullweightbearing gait was initiated. The patient is now capable of walking independently, with no pain, and is highly satisfied. Conclusions: Limb salvage can be successfully performed even in a patient with a severely mangled foot. For successful salvage surgery with good outcomes, such patients should be managed by a team of experienced orthopedic and plastic surgeons from an early stage to achieve appropriate bone alignment and soft tissue coverage.

  2020, Journal of orthopaedic case reports, 9(6) (6), 58 - 61, English, International magazine


• Surgically Treated Nonunion following Ischial Tuberosity Avulsion Fracture of a 14-Year-Old Athlete.

  Yuta Nakamatsu, Tomoaki Fukui, Keisuke Oe, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  A 14-year-old girl experienced acute left buttock pain during a sprint. At the local hospital, she was diagnosed with an avulsion fracture of the left ischial tuberosity. She was kept for observation for about 10 months; however, the buttock pain persisted, and the bone fragments did not unite. She was referred to our hospital approximately 11 months after the injury. Plain radiography revealed an increased transposition of the bone fragment, from 12 mm immediately after the injury to 23 mm. Twelve months after the injury, she underwent osteosynthesis using two cannulated cancellous screws and three suture anchors. Following postoperative rehabilitation, the power in her left hamstring recovered, and she was able to run at full speed and returned to athletics 9 months after the surgery. The operative indications for avulsion fractures of the ischial tuberosity are unclear. Careful follow-up is required as the rate of nonunion after conservative treatment tends to be high. This needs to be identified in order to provide timely treatment that allows for early return to sport. Although she had significant chronic pain and muscle weakness, the surgery successfully treated the fracture, and her muscle power recovered, leading to her return to sports.

  2020, Case reports in orthopedics, 2020, 8531648 - 8531648, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Exploratory clinical trial on the safety and bactericidal effect of 222-nm ultraviolet C irradiation in healthy humans.

  Tomoaki Fukui, Takahiro Niikura, Takahiro Oda, Yohei Kumabe, Hiroyuki Ohashi, Masahiro Sasaki, Tatsushi Igarashi, Makoto Kunisada, Nozomi Yamano, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Shinya Hayashi, Chikako Nishigori, Ryosuke Kuroda

  INTRODUCTION: Surgical site infection is one of the most severe complications of surgical treatments. However, the optimal procedure to prevent such infections remains uninvestigated. Ultraviolet radiation C (UVC) with a short wavelength has a high bactericidal effect; however, it is cytotoxic. Nonetheless, given that UVC with a wavelength of 222 nm reaches only the stratum corneum, it does not affect the skin cells. This study aimed to investigate the safety of 222-nm UVC irradiation and to examine its skin sterilization effect in healthy volunteers. METHODS: This trial was conducted on 20 healthy volunteers. The back of the subject was irradiated with 222-nm UVC at 50-500 mJ/cm2, and the induced erythema (redness of skin) was evaluated. Subsequently, the back was irradiated with a maximum amount of UVC not causing erythema, and the skin swabs before and after the irradiation were cultured. The number of colonies formed after 24 hours was measured. In addition, cyclobutene pyrimidine dimer (CPD) as an indicator of DNA damage was measured using skin tissues of the nonirradiated and irradiated regions. RESULTS: All subjects experienced no erythema at all doses. The back of the subject was irradiated at 500 mJ/cm2, and the number of bacterial colonies in the skin swab culture was significantly decreased by 222-nm UVC irradiation. The CPD amount produced in the irradiated region was slightly but significantly higher than that of the non-irradiated region. CONCLUSION: A 222-nm UVC at 500 mJ/cm2 was a safe irradiation dose and possessed bactericidal effects. In the future, 222-nm UVC irradiation is expected to contribute to the prevention of perioperative infection.

  2020, PloS one, 15(8) (8), e0235948, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Accelerometer-Based Portable Navigation System Is Useful for Tibial Bone Cutting in Modified Kinematically Aligned Total Knee Arthroplasty.

  Masanori Tsubosaka, Tomoyuki Kamenaga, Yuichi Kuroda, Koji Takayama, Shingo Hashimoto, Kazunati Ishida, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  Several studies have reported better clinical outcomes following kinematically aligned total knee arthroplasty (KA-TKA) than mechanically aligned TKA. Consistent reproduction of a KA-TKA is aided by accurate tibial bone resections using computer navigation systems. This study compares an accelerometer-based portable navigation system with a conventional navigation system on tibial bone resection and clinical outcomes in KA-TKA. This study included 60 knees of patients who underwent primary KA-TKA between May 2015 and September 2017. They were randomly assigned to the OrthoPilot and iASSIST groups. A tibial bone cut was performed with 3 degree varus and 7 degree posterior slope in relation to the mechanical axis in all cases. The tibial component angle (TCA) and posterior slope angle (PSA) were evaluated by postoperative radiography, and those that deviated more than 2 degree were set as outliers. The clinical outcomes were the knee range of motion (ROM) and 2011 Knee Society Score (KSS) evaluated at 1 year postoperation. The groups were compared in terms of the TCA, PSA, number of outliers, ROM, and 2011 KSS (p < 0.05). No significant difference was observed between the groups in terms of the mean TCA, PSA, number of outliers, ROM, and categories of the 2011 KSS (objective knee indicators, symptoms, satisfaction, expectations, and functional activities). Although tibial bone cuts were performed with 3 degree varus and 7 degree posterior slope, no significant difference was observed between the OrthoPilot and iASSIST groups in terms of the accuracy of cuts or postoperative clinical result. The iASSIST was found to be a simple and useful navigation system for KA-TKA.

  Dec. 2019, The journal of knee surgery, 34(8) (8), 870 - 876, English, International magazine

  Scientific journal


• Radiographic Comparison of the Mechanical Axis Including Calcaneus to the Conventional Mechanical Axis in Medial Unicompartmental Knee Arthroplasty.

  Yuichi Kuroda, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Shingo Hashimoto, Masanori Tsubosaka, Tomoyuki Kamenaga, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Since a hindfoot alignment is not included in the conventional mechanical axis (hip-ankle [HA] line), a mechanical axis including the calcaneus (hip-calcaneus [HC] line) has recently attracted attention as an alternative weight-bearing line. However, there are few reports on unicompartmental knee arthroplasty (UKA) regarding the HC line. Therefore, this study aimed to compare postoperative alignments after UKA between the HA line and the HC line. Postoperatively, HC radiographs were taken in 88 consecutive patients who underwent medial UKA. The hip-knee-ankle (HKA) and hip-knee-calcaneus (HKC) angles were compared in the same patient. Regarding tibial inclination, the conventional tibial component-ankle (TCA) angle was compared with reference to the HC line (tibial component-calcaneus [TCC] angle). The mean postoperative HKA and HKC angles were 2.8 ± 2.7 and 2.0 ± 2.5 degree, respectively. The mean postoperative TCA and TCC angles were 87.7 ± 2.1 and 88.5 ± 2.1 degree, respectively. There were significant differences between the two groups in both lower limb alignment and tibial component angle. The present study indicated that the HKC and the TCC angles significantly decreased the varus alignment by approximately 1 degree compared with the HKA and TCA angles. Neutral in the HA line corresponds to valgus in reference to the HC line, which may result in overcorrection. Surgeons should consider evaluating the HC line in place of the HA line, which may affect preoperative planning and postoperative outcome during UKA. This is a Level II, diagnostic study.

  Dec. 2019, The journal of knee surgery, 34(9) (9), 930 - 935, English, International magazine

  Scientific journal


• Ras associated with diabetes may play a role in fracture nonunion development in rats.

  Takahiro Oda, Takahiro Niikura, Tomoaki Fukui, Michio Arakura, Keisuke Oe, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Rad is the prototypic member of a subfamily of Ras-related small G-proteins and is highly expressed in the skeletal muscle of patients with type II diabetes. Our previous microarray analysis suggested that Rad may mediate fracture nonunion development. Thus, the present study used rat experimental models to investigate and compare the gene and protein expression patterns of both Rad and Rem1, another RGK subfamily member, in nonunions and standard healing fractures. METHODS: Standard healing fractures and nonunions (produced via periosteal cauterization at the fracture site) were created in the femurs of 3-month-old male Sprague-Dawley rats. At post-fracture days 7, 14, 21, and 28, the fracture callus and fibrous tissue from the standard healing fractures and nonunions, respectively, were harvested and screened (via real-time PCR) for Rad and Rem1 expression. The immunolocalization of both encoded proteins was analyzed at post-fracture days 14 and 21. At the same time points, hematoxylin and eosin staining was performed to identify the detailed tissue structures. RESULTS: Results of real-time PCR analysis showed that Rad expression increased significantly in the nonunions, compared to that in the standard healing fractures, at post-fracture days 14, 21, and 28. Conversely, immunohistochemical analysis revealed the immunolocalization of Rad to be similar to that of Rem1 in both fracture types at post-fracture days 14 and 21. CONCLUSIONS: Rad may mediate nonunion development, and thus, may be a promising therapeutic target to treat these injuries.

  Dec. 2019, BMC musculoskeletal disorders, 20(1) (1), 602 - 602, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Biomechanical Effects of Additional Anterolateral Structure Reconstruction With Different Femoral Attachment Sites on Anterior Cruciate Ligament Reconstruction

  Mai Katakura, Hideyuki Koga, Tomomasa Nakamura, Daisuke Araki, Kanto Nagai, Kyohei Nishida, Ryosuke Kuroda, Takeshi Muneta

  Dec. 2019, American Journal of Sports Medicine, 47(14) (14), 3373 - 3380

  [Refereed]

  Scientific journal


• The Anterolateral Structure of the Knee Does Not Affect Anterior and Dynamic Rotatory Stability in Anterior Cruciate Ligament Injury: Quantitative Evaluation With the Electromagnetic Measurement System

  Daisuke Araki, Takehiko Matsushita, Yuichi Hoshino, Kanto Nagai, Kyohei Nishida, Hideyuki Koga, Tomomasa Nakamura, Mai Katakura, Takeshi Muneta, Ryosuke Kuroda

  Dec. 2019, American Journal of Sports Medicine, 47(14) (14), 3381 - 3388

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Minimally invasive plate osteosynthesis for humeral shaft nonunion: A report of two cases.

  Yoshihito Suda, Keisuke Oe, Tomoaki Fukui, Yutaka Mifune, Atsuyuki Inui, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Introduction: We treated two cases of humeral shaft nonunion by minimally invasive plate osteosynthesis (MIPO) without autogenous bone grafting. Presntation of case: Case 1: An osteosynthesis with intramedullary nailing (IMN) was performed on a 17-year-old female for a humeral shaft fracture at another hospital; however, bony union was not obtained. We removed the nail and screws, then performed MIPO without autogenous bone grafting. At the final follow-up of 4 years after the surgery, she had obtained full range of motion.Case 2: Osteosynthesis with Rush pins had been performed in a 73-year-old female for a humeral shaft fracture at another hospital. Five months later, a revision surgery using IMN was performed at the same hospital; however, this led to nonunion. We removed the IMN and performed MIPO without autogenous bone grafting. At the final follow-up 2 years after surgery, she had obtained full range of motion. Discussion: The cause of nonunion is the lack of mechanical instability and/or biological activity. In these cases, from the findings of radiography and bone scintigraphy, mechanical instability was thought to be the primary cause; therefore, in order to enhance stability, we used a locking plate. Because we can see that these cases are biologically active, we decided not to use bone grafting. Both our cases successfully achieved bony union and excellent functional recovery using this method. Conclusion: We performed MIPO without exposure of the nonunion site and autogenous bone grafting in two cases of humeral shaft nonunion, and obtained successful clinical outcomes.

  Dec. 2019, Annals of medicine and surgery (2012), 48, 43 - 47, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• PS-TKAにおける術中軟部組織バランスが術後1年の移動歩行能力に及ぼした影響

  生田 健明, 村津 裕嗣, 立花 章太郎, 平中 良明, 大島 隆司, 古賀 敬章, 松本 知之, 圓尾 明弘, 宮 秀俊, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2019, 日本人工関節学会誌, 49, 55 - 56, Japanese


• 患者年齢はTKA術後満足度の関連因子に影響を及ぼす

  立花 章太郎, 村津 裕嗣, 生田 健明, 大島 隆司, 松本 知之, 宮 秀俊, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2019, 日本人工関節学会誌, 49, 449 - 450, Japanese


• 人工膝関節全置換術の術後下肢機能回復に及ぼす手術時年齢の影響

  生田 健明, 村津 裕嗣, 立花 章太郎, 平中 良明, 大島 隆司, 古賀 敬章, 松本 知之, 圓尾 明弘, 宮 秀俊, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2019, 日本人工関節学会誌, 49, 657 - 658, Japanese


• Therapeutic potential of vascular stem cells for anterior cruciate ligament reconstruction.

  Tomoyuki Matsumoto, Koji Takayama, Shinya Hayashi, Takahiro Niikura, Takehiko Matsushita, Ryosuke Kuroda

  Dec. 2019, Annals of translational medicine, 7(Suppl 8) (Suppl 8), S286, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 神経障害性疼痛に対する末梢神経ハイドロリリースの治療効果

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  日本末梢神経学会, Dec. 2019, 末梢神経, 30(2) (2), 284 - 284, Japanese


• 手術加療を行った真の神経原性胸郭出口症候群の3症例

  向原 伸太郎, 乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 吉川 智也, 関口 兼司, 黒田 良祐

  日本末梢神経学会, Dec. 2019, 末梢神経, 30(2) (2), 300 - 300, Japanese

  [Refereed]


• Topical cutaneous application of carbon dioxide via a hydrogel for improved fracture repair: results of phase I clinical safety trial.

  Takahiro Niikura, Takashi Iwakura, Takashi Omori, Sang Yang Lee, Yoshitada Sakai, Toshihiro Akisue, Keisuke Oe, Tomoaki Fukui, Takehiko Matsushita, Tomoyuki Matsumoto, Ryosuke Kuroda

  BACKGROUND: Clinicians have very limited options to improve fracture repair. Therefore, it is critical to develop a new clinically available therapeutic option to assist fracture repair biologically. We previously reported that the topical cutaneous application of carbon dioxide (CO2) via a CO2 absorption-enhancing hydrogel accelerates fracture repair in rats by increasing blood flow and angiogenesis and promoting endochondral ossification. The aim of this study was to assess the safety and efficacy of CO2 therapy in patients with fractures. METHODS: Patients with fractures of the femur and tibia were prospectively enrolled into this study with ethical approval and informed consent. The CO2 absorption-enhancing hydrogel was applied to the fractured lower limbs of patients, and then 100% CO2 was administered daily into a sealed space for 20 min over 4 weeks postoperatively. Safety was assessed based on vital signs, blood parameters, adverse events, and arterial and expired gas analyses. As the efficacy outcome, blood flow at the level of the fracture site and at a site 5 cm from the fracture in the affected limb was measured using a laser Doppler blood flow meter. RESULTS: Nineteen patients were subjected to complete analysis. No adverse events were observed. Arterial and expired gas analyses revealed no adverse systemic effects including hypercapnia. The mean ratio of blood flow 20 min after CO2 therapy compared with the pre-treatment level increased by approximately 2-fold in a time-dependent manner. CONCLUSIONS: The findings of the present study revealed that CO2 therapy is safe to apply to human patients and that it can enhance blood flow in the fractured limbs. TRIAL REGISTRATION: This study has been registered in the UMIN Clinical Trials Registry (Registration number: UMIN000013641, Date of registration: July 1, 2014).

  Nov. 2019, BMC musculoskeletal disorders, 20(1) (1), 563 - 563, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Adequate Positioning of the Tibial Component Is Key to Avoiding Bearing Impingement in Oxford Unicompartmental Knee Arthroplasty.

  Kamenaga T, Hiranaka T, Takayama K, Tsubosaka M, Kuroda R, Matsumoto T

  BACKGROUND: Bearing dislocation is a serious complication of unicompartmental knee arthroplasty (UKA) with the Oxford knee prosthesis equipped with a mobile bearing. We aimed to clarify the extent of intraoperative movement of the mobile bearing and its relationship with the positioning of prosthesis components in patients undergoing Oxford UKA. METHODS: This retrospective study included 50 patients (50 knees) who underwent Oxford UKA for anteromedial osteoarthritis or osteonecrosis of the knee. Intraoperative bearing movement was assessed at various angles of knee flexion (0°, 30°, 60°, 90°, and 120°). We stratified patients according to the extent of bearing movement posteriorly during intraoperative knee flexion, with or without contacting the lateral wall of the tibial component (with contact, 20 knees; without contact, 30 knees). Postoperative radiographic evaluations were conducted at 1 week postoperatively to assess the positional parameters of the tibial and femoral components (varus/valgus alignment, rotation, mediolateral position). Clinical evaluations were conducted at 1 year postoperatively (maximum flexion angle, Oxford Knee Score). RESULTS: Abnormal intraoperative movement of the mobile bearing resulting in contact with the lateral wall of the tibial component was associated with a significantly more medial position and external rotation of the tibial component, as well as poorer improvement in knee flexion angle at 1 year postoperatively. CONCLUSION: In Oxford UKA recipients, the bearing may impinge on the lateral wall of the tibial component during flexion above 60° if the tibial component is placed too medially or exhibits pronounced external rotation, which may limit knee function improvement postoperatively.

  Nov. 2019, The Journal of arthroplasty, 34(11) (11), 2606 - 2613, English, International magazine

  [Refereed]

  Scientific journal


• A Development of Measurement System for Radioulnar Instability by Using 3D Electromagnetic Sensor and Pressure Sensor

  Akito Nakano, Kouki Nagamune, Atsuyuki Inui, Shintaro Mukohara, Kohei Yamaura, Ryosuke Kuroda

  Institute of Electrical and Electronics Engineers Inc., Nov. 2019, 2019 IEEE International Conference on Electrical, Control and Instrumentation Engineering, ICECIE 2019 - Proceedings, English

  International conference proceedings


• ACL再建によってPivot-shiftが消失した膝における過制動の有無の調査

  森 昭嘉, 星野 祐一, 中西 雄太, 山本 哲也, 山下 貴大, 寛島 佑史, 宮地 伸晃, 長井 寛斗, 荒木 大輔, 神崎 至幸, 松下 雄彦, 長宗 高樹, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Nov. 2019, 日本臨床スポーツ医学会誌, 27(4) (4), S173 - S173, Japanese


• 入院中のアスリートの患者のケアについて 健康運動看護師としての取り組み

  古賀 由希子, 田中 舞衣, 荒木 大輔, 松下 雄彦, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Nov. 2019, 日本臨床スポーツ医学会誌, 27(4) (4), S187 - S187, Japanese


• スポーツ選手における半月板単独損傷に対する半月板縫合術の治療成績

  中西 雄太, 長井 寛斗, 松下 雄彦, 荒木 大輔, 神崎 至幸, 星野 祐一, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Nov. 2019, 日本臨床スポーツ医学会誌, 27(4) (4), S249 - S249, Japanese


• 膝前十字靱帯解剖学的二重束再建術における骨孔重複が主観的膝機能に及ぼす影響の調査

  抽冬 晃司, 星野 祐一, 森 昭嘉, 中西 雄太, 山本 哲也, 山下 貴大, 宮地 伸晃, 長井 寛斗, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Nov. 2019, 日本臨床スポーツ医学会誌, 27(4) (4), S250 - S250, Japanese


• 前十字靱帯再建術術前の膝伸展筋力と術後1年でのスポーツ復帰の関連

  上田 雄也, 松下 雄彦, 柴田 洋平, 瀧口 耕平, 荒木 大輔, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Nov. 2019, 日本臨床スポーツ医学会誌, 27(4) (4), S171 - S171, Japanese


• MRI-determined anterolateral capsule injury did not affect the pivot-shift in anterior cruciate ligament-injured knees.

  Nobuaki Miyaji, Yuichi Hoshino, Toshikazu Tanaka, Kyohei Nishida, Daisuke Araki, Noriyuki Kanzaki, Takehiko Matsushita, Ryosuke Kuroda

  PURPOSE: The purpose of this study was to quantitatively compare the results of pivot-shift test between knees with anterior cruciate ligament (ACL) injury with and without anterolateral capsule (ALC) injury detected on MRI. ALC injury was hypothesized to worsen rotatory knee laxity. METHODS: 82 patients with unilateral ACL injury were enrolled in this study. The pivot-shift test was performed under anesthesia before ACL reconstruction. Two evaluations were conducted simultaneously: IKDC clinical grading and the quantitative evaluation using an electromagnetic measurement system that determined tibial acceleration (m/s2). Two examiners identified the ALC injury on magnetic resonance imaging (MRI) and stratified patients into two groups: ALC-injured (ALC+) and ALC-intact (ALC-). ALC injury was diagnosed if the signal intensity on coronal T2-weighted sequences is increased. After confirming the reliability of the MRI, the difference in the pivot-shift between two groups was assessed. RESULTS: Because of the poor agreement between examiners with respect to the ALC evaluations (κ coefficient of 0.25 and 58.5% concordance), the result from each examiner was analyzed separately. Examiner 1 found ALC injury in 42/82 knees (51%). The two groups had similar clinical grading (glide/clunk/gross: ALC+ group 21/18/3cases vs. ALC- group 21/16/3cases) (n.s.). Tibial acceleration during pivot-shift was also similar in the ALC+ (1.4 ± 1.2 m/s2) and ALC- (1.7 ± 1.3 m/s2) groups (n.s.). Examiner 2 found ALC injury in 28/82 knees (34%). Differences in clinical grading were not observed (glide/clunk/gross: ALC+ group 16/9/3 vs. ALC- group 26/25/3) (n.s.). However, the tibial acceleration in the ALC+ group (1.2 ± 0.8 m/s2) was significantly lower than that in the ALC- group (1.7 ± 1.3 m/s2, p = 0.03). CONCLUSION: Concomitant ALC injury in knees with ACL injury was not consistently detected on MRI and did not affect rotatory knee laxity. LEVEL OF EVIDENCE: Case-control study, level III.

  Nov. 2019, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 27(11) (11), 3426 - 3431, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 人工膝関節置換術の術後疼痛に影響を与える因子の検討

  吉川 遼, 酒井 良忠, 大西 宏和, 今村 愛生, 松本 腱, 原田 理沙, 向井 拓也, 新倉 隆宏, 黒田 良祐

  (公社)日本リハビリテーション医学会, Oct. 2019, The Japanese Journal of Rehabilitation Medicine, 56(秋季特別号) (秋季特別号), S271 - S271, Japanese


• 超音波画像診断装置を用いた大腿四頭筋厚の測定における検者内および検者間信頼性の検討

  松本 健, 原田 理沙, 高宮 大輝, 吉川 遼, 三浦 靖史, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, Oct. 2019, The Japanese Journal of Rehabilitation Medicine, 56(秋季特別号) (秋季特別号), S328 - S328, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  平田 悠, 野村 和弘, 小林 憲太, 岡本 士毅, 箕越 靖彦, 今村 道博, 武田 伸一, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 細岡 哲也, 小川 渉

  (一社)日本肥満学会, Oct. 2019, 肥満研究, 25(Suppl.) (Suppl.), 260 - 260, Japanese


• プロ野球投手におけるGIRDに関連する因子の検討

  美舩 泰, 乾 淳幸, 山裏 耕平, 西本 華子, 片岡 武史, 黒澤 堯, 向原 伸太郎, 吉川 智也, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2019, 日本肩関節学会抄録集, 46回, 131 - 131, Japanese


• 終末糖化産物に対するアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 山裏 耕平, 向原 伸太郎, 吉川 智也, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2019, 日本肩関節学会抄録集, 46回, 288 - 288, Japanese


• 化膿性肩関節炎の治療経験

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2019, 日本肩関節学会抄録集, 46回, 295 - 295, Japanese


• プロ野球投手の肩関節コンディションと股関節可動域スコアの関係

  美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 吉川 智也, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2019, 日本肩関節学会抄録集, 46回, 360 - 360, Japanese


• 変形性膝関節症に対する骨切り術の最先端 骨軟骨柱移植を併用した高位脛骨骨切り術

  松下 雄彦, 星野 祐一, 荒木 大輔, 長井 寛斗, 宮地 伸晃, 森 昭嘉, 渡邊 秀, 抽冬 晃司, 神崎 至幸, 黒田 良祐

  (一社)日本関節病学会, Oct. 2019, 日本関節病学会誌, 38(3) (3), 225 - 225, Japanese


• Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice.

  Yohei Kawakami, William S Hambright, Koji Takayama, Xiaodong Mu, Aiping Lu, James H Cummins, Tomoyuki Matsumoto, Takashi Yurube, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H Fu, Paul D Robbins, Laura J Niedernhofer, Johnny Huard

  Aging-related loss of adult stem cell function contributes to impaired tissue regeneration. Mice deficient in zinc metalloproteinase STE24 (Zmpste24-/-) exhibit premature age-related musculoskeletal pathologies similar to those observed in children with Hutchinson-Gilford progeria syndrome (HGPS). We have reported that muscle-derived stem/progenitor cells (MDSPCs) isolated from Zmpste24-/- mice are defective in their proliferation and differentiation capabilities in culture and during tissue regeneration. The mechanistic target of rapamycin complex 1 (mTORC1) regulates cell growth, and inhibition of the mTORC1 pathway extends the lifespan of several animal species. We therefore hypothesized that inhibition of mTORC1 signaling would rescue the differentiation defects observed in progeroid MDSPCs. MDSPCs were isolated from Zmpste24 -/- mice, and the effects of mTORC1 on MDSPC differentiation and function were examined. We found that mTORC1 signaling was increased in senescent Zmpste24-/- MDSPCs, along with impaired chondrogenic, osteogenic, and myogenic differentiation capacity versus wild-type MDSPCs. Interestingly, we observed that mTORC1 inhibition with rapamycin improved myogenic and chondrogenic differentiation and reduced levels of apoptosis and senescence in Zmpste24-/- MDSPCs. Our results demonstrate that age-related adult stem/progenitor cell dysfunction contributes to impaired regenerative capacities and that mTORC1 inhibition may represent a potential therapeutic strategy for improving differentiation capacities of senescent stem and muscle progenitor cells.

  Sep. 2019, Molecular therapy. Methods & clinical development, 14, 64 - 76, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Insufficiency and deficiency of vitamin D in elderly patients with fragility fractures of the hip in the Japanese population.

  Niikura T, Oe K, Sakai Y, Iwakura T, Fukui T, Nishimoto H, Hayashi S, Matsumoto T, Matsushita T, Maruo A, Yagata Y, Kishimoto K, Sakurai A, Kuroda R

  Sep. 2019, Journal of orthopaedic surgery (Hong Kong), 27(3) (3), 2309499019877517, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 炭酸ガス経皮吸収はウサギ脛骨骨延長術における骨形成を促進する

  隈部 洋平, 新倉 隆宏, 福井 友章, 高原 俊介, 黒岩 祐, 新倉 路生, 大江 啓介, 小田 崇弘, 澤内 健一, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1622 - S1622, Japanese


• 炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおいて骨癒合を促進させる

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 新倉 路生, 黒岩 祐, 隈部 洋平, 澤内 健一, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1755 - S1755, Japanese


• 人工関節全置換術後に発症した急性膝窩動脈閉塞症を保存的に治療し得た2例

  前田 琢磨, 松本 知之, 高山 考治, 林 申也, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(5) (5), 803 - 804, Japanese


• Charcot-Marie-Tooth病に伴う神経病性膝関節症に対し拘束型人工膝関節全置換術を施行した2例

  江原 豊, 松本 知之, 高山 孝治, 林 申也, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(5) (5), 805 - 806, Japanese


• 片麻痺が大腿骨近位部骨折に及ぼす影響についての検討

  吉川 遼, 山本 潤哉, 丸野 文雅, 西本 華子, 新倉 隆宏, 酒井 良忠, 黒田 良祐, 橋本 靖

  (一社)日本骨粗鬆症学会, Sep. 2019, 日本骨粗鬆症学会雑誌, 5(Suppl.1) (Suppl.1), 365 - 365, Japanese


• 自己免疫性多内分泌腺症候群2型による続発性骨軟化症にて両側脛骨近位端骨折を生じた1例

  中川 大輔, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(秋季学会) (秋季学会), 109 - 109, Japanese


• 腫瘍性骨軟化症による大腿骨頸部病的骨折をきたした1例

  井上 悠, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(5) (5), 958 - 958, Japanese


• 非定型大腿骨骨折術後偽関節の治療経験

  新倉 隆宏, 西本 華子, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2019, 日本骨粗鬆症学会雑誌, 5(Suppl.1) (Suppl.1), 457 - 457, Japanese


• 化膿性肩関節炎に対する治療経験

  吉川 智也, 美舩 泰, 乾 淳幸, 西本 華子, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(秋季学会) (秋季学会), 147 - 147, Japanese


• 肘関節開放脱臼骨折に合併したMycobacterium fortuitum感染症の一例

  村尾 仁美, 乾 淳幸, 美舩 泰, 西本 華子, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(秋季学会) (秋季学会), 149 - 149, Japanese


• Vocabulary 終末糖化産物

  黒澤 尭, 美舩 泰, 乾 淳幸, 黒田 良祐

  (株)南江堂, Sep. 2019, 整形外科, 70(10) (10), 1104 - 1104, Japanese


• 肩腱板由来細胞における終末糖化産物による酸化ストレスに対するアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1694 - S1694, Japanese


• 高血糖誘導酸化ストレスを与えた腱細胞に対するDHEAの効果

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 尭, 山裏 耕平, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1698 - S1698, Japanese


• 糖尿病性腱障害モデルに対するアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1699 - S1699, Japanese


• 高血糖ストレスモデルを用いたラット腱細胞における老化制御因子NMN(nicotinamide mononucleotide)の抗酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 尭, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1699 - S1699, Japanese


• 三次元電磁気センサを使用した前腕回旋運動の定量的評価の試み

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 尭, 山裏 耕平, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1769 - S1769, Japanese


• 骨格筋不動化による筋萎縮・脂肪細胞浸潤と慢性炎症の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 国分 毅, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1867 - S1867, Japanese


• 治療薬別のTrabecular Bone Score(TBS)値およびBone Mineral Density(BMD)値の2年間の推移 TBSは治療の効果判定に有用か

  西本 華子, 乾 淳幸, 美舩 泰, 今堀 正也, 新倉 隆宏, 鷲見 正敏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2019, 日本骨粗鬆症学会雑誌, 5(Suppl.1) (Suppl.1), 283 - 283, Japanese


• 膝半月板横断裂に対する新たに開発したcross tie grip sutureと従来法との強度比較試験

  中西 雄太, 荒木 大輔, 長宗 高樹, 山本 哲也, 松下 雄彦, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(秋季学会) (秋季学会), 88 - 88, Japanese


• マウス変形性膝関節症モデルにおけるSIRT1活性化薬剤SRT2014投与による変形性関節症進行抑制効果

  宮地 伸晃, 松下 雄彦, 田中 聡一, 山本 哲也, 山下 貴大, 荒木 大輔, 神崎 至幸, 星野 祐一, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1684 - S1684, Japanese


• 健常成人における歩行中の足底圧評価 In shoe systemを用いた解析

  山本 哲也, 神崎 至幸, 星野 祐一, 山下 貴大, 茨木 一行, 長宗 高樹, 荒木 大輔, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1771 - S1771, Japanese


• 内反型変形性膝関節症患者における立位と臥位の下肢アライメントの違い 高位脛骨骨切り術の術前計画に及ぼす影響

  寛島 佑史, 松下 雄彦, 中西 雄太, 山本 哲也, 山下 貴大, 宮地 伸晃, 茨木 一行, 荒木 大輔, 神崎 至幸, 星野 祐一, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1847 - S1847, Japanese


• 半月板横断裂に対するcross tie grip sutureと従来縫合法の力学試験による比較

  中西 雄太, 荒木 大輔, 長宗 高樹, 山本 哲也, 長井 寛斗, 神崎 至幸, 星野 祐一, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1920 - S1920, Japanese


• 大腿骨遠位骨切り術および高位脛骨骨切り術(double-level osteotomy)後に発生したcheckrein変形の1例

  安部 真人, 松下 雄彦, 神崎 至幸, 荒木 大輔, 星野 祐一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(5) (5), 943 - 944, Japanese


• 術前10度以上の内反変形を伴う症例に施行した人工足関節置換術の術後成績

  山下 貴大, 神崎 至幸, 山本 哲也, 茨木 一行, 黒田 良祐

  (一社)日本足の外科学会, Aug. 2019, 日本足の外科学会雑誌, 40(1) (1), 186 - 189, Japanese


• 足根骨癒合症の治療成績

  杜多 昭彦, 柴沼 均, 神崎 至幸, 黒田 良祐, 高倉 義幸, 高倉 義典

  (一社)日本足の外科学会, Aug. 2019, 日本足の外科学会雑誌, 40(1) (1), 128 - 131, Japanese


• 整形外科治療の費用対効果 転移性脊椎腫瘍に対する集学的治療の費用対効用

  角谷 賢一朗, 宮崎 真吾, 由留部 崇, 張 鐘穎, 垣内 裕司, 黒田 良祐

  (株)医学書院, Aug. 2019, 臨床整形外科, 54(8) (8), 777 - 783, Japanese


• Subfibular ossicleを伴う足関節外側不安症例に対する鏡視下外側靱帯修復術の手術成績

  茨木 一行, 神崎 至幸, 山本 哲也, 山下 貴大, 黒田 良祐

  (一社)日本足の外科学会, Aug. 2019, 日本足の外科学会雑誌, 40(1) (1), 73 - 76, Japanese


• TNK人工足関節を使用した人工足関節置換術後における脛骨・距骨コンポーネントの設置角度のX線学的検討

  山本 哲也, 神崎 至幸, 山下 貴大, 茨木 一行, 黒田 良祐

  (一社)日本足の外科学会, Aug. 2019, 日本足の外科学会雑誌, 40(1) (1), 42 - 45, Japanese


• 若手医師のための経験すべき"領域別"手術講座 膝(PART 1) 前十字靱帯再建術(屈筋腱を用いる方法)

  星野 祐一, 荒木 大輔, 松下 雄彦, 黒田 良祐

  (株)メディカ出版, Aug. 2019, 整形外科Surgical Technique, 9(4) (4), 470 - 476, Japanese


• Influence of advanced glycation end products on rotator cuff.

  Mifune Y, Inui A, Muto T, Nishimoto H, Kataoka T, Kurosawa T, Yamaura K, Mukohara S, Niikura T, Kokubu T, Kuroda R

  BACKGROUND: Most rotator cuff tears are the result of age-related degenerative changes, but the mechanisms underlying these changes have not been reported. Recently, advanced glycation end products (AGEs) have been regarded as an important factor in senescence. Therefore, we hypothesized that AGEs would have detrimental effects on rotator cuff-derived cells. In this study, we investigated the influence of AGEs on rotator cuff-derived cells in vitro and ex vivo. METHODS: Rotator cuff-derived cells were obtained from human supraspinatus tendons. The cells were cultured in the following media: (1) regular medium with 500 μg/mL AGEs (High-AGEs), (2) regular medium with 100 μg/mL AGEs (Low-AGEs), and (3) regular medium alone (Control). Cell viability, secretion of vascular endothelial growth factor, and the expressions of hypoxia-inducible factor-1α, reactive oxygen species, and apoptosis were assessed after cultivation. An ex vivo tissue culture with AGEs was also performed to measure the tensile strength. RESULTS: Cell viability in the High-AGEs group was significantly suppressed relative to that in the Controls. The amount of vascular endothelial growth factor secretion was significantly greater in the High- and Low-AGEs groups than in the Controls. Immunofluorescence stain demonstrated enhancement of hypoxia-inducible factor-1α and reactive oxygen species expressions and cell apoptosis in the High- and Low-AGEs groups relative to that in the Controls. In ex vivo mechanical testing, tensile strength was significantly higher in the Control group than in the AGEs groups. DISCUSSION: These results indicated that AGEs caused age-related degenerative rotator cuff changes. The reduction of AGEs might prevent rotator cuff senescence-related degeneration.

  Aug. 2019, Journal of shoulder and elbow surgery, 28(8) (8), 1490 - 1496, English, International magazine

  [Refereed]

  Scientific journal


• Clinical Outcomes of Total Ankle Arthroplasty With Total Talar Prosthesis.

  Kanzaki N, Chinzei N, Yamamoto T, Yamashita T, Ibaraki K, Kuroda R

  Aug. 2019, Foot & ankle international, 40(8) (8), 948 - 954

  [Refereed]


• Medial knee stability at flexion increases tibial internal rotation and knee flexion angle after posterior-stabilized total knee arthroplasty.

  Kamenaga T, Takayama K, Ishida K, Muratsu H, Hayashi S, Hashimoto S, Kuroda Y, Tsubosaka M, Takashima Y, Matsushita T, Niikura T, Kuroda R, Matsumoto T

  BACKGROUND: Soft-tissue balance is an important element for the success of total knee arthroplasty; however, the influence of intraoperative soft-tissue balance on knee kinematics in posterior-stabilized-total knee arthroplasty remains unknown. We investigated whether intraoperative soft-tissue balance could influence knee kinematics and flexion angle after posterior-stabilized-total knee arthroplasty. METHODS: This study included 30 patients with knee osteoarthritis and varus alignment who underwent posterior-stabilized total knee arthroplasty; intraoperative soft-tissue balance parameters, such as varus ligament balance and joint component gap, were assessed by an offset-type tensor at knee flexion angles of 0°, 10°, 30°, 60°, 90°, 120°, and 135°. Medial and lateral compartment gaps were calculated. The amount of tibial internal rotation was determined between 60° and 135° flexion by the navigation system. Simple linear regression analysis was used to analyze the effects of intraoperative soft-tissue balance on tibial internal rotation. Linear regression analysis was used to assess correlation between tibial internal rotation and postoperative knee flexion angle. FINDINGS: Medial compartment gaps at 60° (r = -0.57, P < 0.05) and 90° (r = -0.60, P < 0.05) of flexion were significantly negatively correlated with tibial internal rotation. Moreover, tibial internal rotation showed a significant correlation with the 2-year postoperative knee flexion angle (r = 0.50, P < 0.05) and improvement in knee flexion angle (r = 0.61, P < 0.05). INTERPRETATION: Thus, smaller medial compartment gaps at 60° and 90° of flexion play an important role in achieving medial pivot motion with tibial internal rotation; moreover, tibial internal rotation provides a better flexion angle after posterior-stabilized total knee arthroplasty.

  Aug. 2019, Clinical biomechanics (Bristol, Avon), 68, 16 - 22, English, International magazine

  [Refereed]

  Scientific journal


• Medial clavicle pseudarthrosis successfully treated with an inverted distal clavicle locking plate.

  Yu Sasaki, Sang Yang Lee, Takashi Iwakura, Tomoaki Fukui, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Teruya Kawamoto, Yutaka Mifune, Ryosuke Kuroda, Takahiro Niikura

  Introduction: Medial clavicle fractures are rare injuries. Symptomatic nonunion arises up to 8% of medial clavicle fractures when treated conservatively. Presentation of case: A 53-year-old man sustained a left medial clavicle fracture and was treated conservatively at another hospital. Nine months after his initial injury, he was referred to our institution. We diagnosed pseudarthrosis of the medial clavicle. We performed open reduction and internal fixation using an inverted distal clavicle locking plate. At the 1-year follow-up, radiographs showed bone union. Discussion: This is the first reported case of medial clavicle pseudarthrosis treated with an inverted distal clavicle anatomical locking plate. There are several advantages in using this plate. Conclusion: This method is a good treatment option.

  Aug. 2019, Annals of medicine and surgery (2012), 44, 1 - 4, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• The Analysis of Cost-utility of Multidisciplinary Treatment for Spinal Metastasis

  角谷 賢一朗, 宮崎 真吾, 由留部 崇, 張 鐘穎, 垣内 裕司, 黒田 良祐

  医学書院, Aug. 2019, 臨床整形外科, 54(8) (8), 777 - 783, Japanese


• 前十字靱帯再々建術または反対側再建術後1年における膝関節筋力と主観的評価の関連

  上田 雄也, 松下 雄彦, 柴田 洋平, 瀧口 耕平, 荒木 大輔, 神崎 至幸, 星野 祐一, 小野 玲, 酒井 良忠, 黒田 良祐

  (公社)日本理学療法士協会, Aug. 2019, 理学療法学, 46(Suppl.1) (Suppl.1), P4 - 6, Japanese

  [Refereed]


• Gemcitabine and docetaxel combination chemotherapy for advanced bone and soft tissue sarcomas: Protocol for an open-label, non-randomised, Phase 2 study

  Hitomi Hara, Teruya Kawamoto, Naomasa Fukase, Yohei Kawakami, Toshiyuki Takemori, Shuichi Fujiwara, Kazumichi Kitayama, Kotaro Nishida, Ryosuke Kuroda, Toshihiro Akisue

  Jul. 2019, BMC Cancer, 19(1) (1), 725

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 母指MP関節過伸展を伴う背側不安定症に対して掌側板修復術を施行した2例

  田中 悟, 乾 淳幸, 西本 華子, 美舩 泰, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Jul. 2019, 中部日本整形外科災害外科学会雑誌, 62(4) (4), 747 - 748, Japanese


• Expression profiling of genes in rheumatoid fibroblast-like synoviocytes regulated by tumor necrosis factor-like ligand 1A using cDNA microarray analysis.

  Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Ryosuke Kuroda

  Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation in synovial tissues. Hyperplasia of synovial tissue leads to the formation of pannus, which invades joint cartilage and bone resulting in joint destruction. Tumor necrosis factor-like ligand 1A (TL1A), a member of the tumor necrosis factor superfamily (TNFSF15), contributes to the pathogenesis of autoimmune diseases, including RA. In the present study, a cDNA microarray was used to search for genes whose expression in rheumatoid fibroblast-like synoviocytes (RA-FLS) were regulated by TL1A. Four individual lines of primary cultured RA-FLS were incubated either with recombinant human TL1A protein or phosphate-buffered saline, as an unstimulated control, for 12 h. Gene expression was then detected through the microarray assay. The results revealed the expression profiles of genes in RA-FLS regulated by TL1A. The present study also demonstrated the functions of those genes whose expression in RA-FLS was regulated by TL1A. Among the genes in this profile, the present study focused on the following genes: Spectrin repeat-containing nuclear envelope 1, Fc receptor-like 2, PYD (pyrin domain)-containing 1, cell division cycle 45 homolog, signal transducer and activator of transcription 5B, and interferon regulatory factor 4. These genes may affect the pathogenesis of RA, including proliferation, regulation of B cells and T cells, inflammation, and cytokine processing. The present study revealed for the first time, to the best of our knowledge, the expression profile of genes in RA-FLS regulated by TL1A. The data indicate that TL1A may regulate the gene expression of various key molecules in RA-FLS, thus affecting the pathogenesis of RA. Further investigations of the genes detected in the current profiles may provide a deeper understanding of the pathogenesis and a novel target for the treatment of RA.

  Jul. 2019, Biomedical reports, 1(1) (1), 1 - 5, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Denosumab Treatment Improved Health-Related Quality of Life in Osteoporosis: A Prospective Cohort Study.

  Shinya Hayashi, Koji Fukuda, Toshihisa Maeda, Nobuaki Chinzei, Shinsuke Kihara, Yasushi Miura, Yoshitada Sakai, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Takahiro Niikura, Ryosuke Kuroda

  Improving patient health-related quality of life (HRQOL) and prevention of bone fracture are important components of the treatment of osteoporosis. Our aim in this study was to evaluate the effect of denosumab treatment in improving HRQOL among patients with osteoporosis. Our analysis was based on 332 patients with osteoporosis, followed for 24 months. All patients received denosumab (60 mg) subcutaneously every 6 months. Bone mineral density (BMD) was assessed at the distal radius, with serum concentration of calcium, phosphate, P1NP, and TRACP5b also measured. HRQOL assessment included pain (visual analogue scale [VAS]) and the EQ-5D questionnaire. A multivariate analysis was performed to identify the possible confounders associated with deterioration in the EQ-5D utility score in response to denosumab treatment. Denosumab treatment yielded a 3.4% increase in BMD at 24 months. Serum levels of TRACP5b and P1NP decreased significantly, from baseline, at 6 months, with no effect on calcium and phosphate levels. Pain VAS and EQ-5D utility score improved significantly, from baseline, at 6 months, with the EQ-5D utility score correlating with the BMD at all time points of measurement over the 24-month period of observation. Knee osteoarthritis and multiple comorbidities were significantly associated with a worse HRQOL in response to denosumab treatment. Denosumab treatment increased BMD, with improvements in BMD correlating with improved HRQOL, supporting a possible benefit of using denosumab for the treatment of osteoporosis. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

  Jul. 2019, JBMR plus, 3(7) (7), e10191, English, International magazine

  [Refereed]

  Scientific journal


• Valgus Subsidence of the Tibial Component Caused by Tibial Component Malpositioning in Cementless Oxford Mobile-Bearing Unicompartmental Knee Arthroplasty.

  Kamenaga T, Hiranaka T, Nakanishi Y, Takayama K, Kuroda R, Matsumoto T

  BACKGROUND: Valgus subsidence (VS) of the tibial component is a rare complication of unicompartmental knee arthroplasty (UKA), and surgeons might consider revision surgery. The present study aimed to identify the factors related to VS of the tibial component after cementless Oxford mobile-bearing UKA. METHODS: The study included 120 patients who underwent Oxford mobile-bearing UKA using a cementless tibial component in our center between September 2015 and September 2016. Six showed VS of >2° after surgery. Patients were stratified into 2 groups according to the occurrence of VS of the tibial component (VS group, n = 6; no-subsidence group, n = 114). Postoperative radiographic evaluations were conducted to assess the varus/valgus alignment, rotation, and mediolateral position of the tibial and femoral components. The Oxford Knee Score (OKS) was assessed at 3, 6, and 12 months postoperatively. Positional parameters and sequential change in OKS were compared between the two groups using unpaired t-test (P < .05, statistically significant). RESULTS: At 3 months postoperatively, an average VS of 3.4° in the VS group was observed, with a significant decrease in OKS. VS was associated with a significantly more medial position and external rotation of the tibial component. After 3 months, VS stopped, and the OKS gradually improved without revision surgery. CONCLUSIONS: VS might be caused by the malpositioning of the tibial component. VS of the tibial component after UKA appears to stop, with simultaneous pain relief, even without revision after 3 months postoperatively.

  Jul. 2019, The Journal of arthroplasty, 34(12) (12), 3054 - 3060, English, International magazine

  [Refereed]

  Scientific journal


• 母指MP関節過伸展を伴う背側不安定症に対して掌側板修復術を施行した2例

  田中 悟, 乾 淳幸, 西本 華子, 美舩 泰, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Jul. 2019, 中部日本整形外科災害外科学会雑誌, 62(4) (4), 747 - 748, Japanese


• 上腕骨遠位coronal shear fractureの治療成績

  向原 伸太郎, 乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 黒田 司, 脇 貴洋, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S201 - S201, Japanese


• 骨欠損部へのヒトiPS細胞移植 軟骨内骨化を介した骨再生の試み

  李 相亮, 新倉 路生, 福井 友章, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S100 - S100, Japanese


• Masquelet法で治療した患者におけるinduced membraneの組織学的評価

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S167 - S167, Japanese


• 下肢長管骨偽関節に対するロッキングプレートを用いた手術の治療成績

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S170 - S170, Japanese


• 文書を用いた患者説明によるLIPUSコンプライアンス向上の効果

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S378 - S378, Japanese


• 大腿骨頸部骨折の術後CT画像評価方法の検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐, 岩倉 崇, 櫻井 敦志

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S420 - S420, Japanese


• 骨欠損部へのヒトiPS細胞移植 軟骨内骨化を介した骨再生の試み

  李 相亮, 新倉 路生, 福井 友章, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S100 - S100, Japanese


• Masquelet法で治療した患者におけるinduced membraneの組織学的評価

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S167 - S167, Japanese


• 下肢長管骨偽関節に対するロッキングプレートを用いた手術の治療成績

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S170 - S170, Japanese


• 文書を用いた患者説明によるLIPUSコンプライアンス向上の効果

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S378 - S378, Japanese


• 大腿骨頸部骨折の術後CT画像評価方法の検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐, 岩倉 崇, 櫻井 敦志

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S420 - S420, Japanese


• 上腕骨遠位coronal shear fractureの治療成績

  向原 伸太郎, 乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 黒田 司, 脇 貴洋, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S201 - S201, Japanese


• Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction.

  Y Kakiuchi, T Yurube, K Kakutani, T Takada, M Ito, Y Takeoka, Y Kanda, S Miyazaki, R Kuroda, K Nishida

  OBJECTIVE: The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that integrates nutrients to execute cell growth. We hypothesized that mTOR is influential in the intervertebral disc-largest avascular, low-nutrient organ. Our objective was to identify the optimal mTOR inhibitor for treating human degenerative disc disease. DESIGN: mTOR complex 1 (mTORC1) regulates p70/ribosomal S6 kinase (p70/S6K), negatively regulates autophagy, and is controlled by Akt. Akt is controlled by phosphatidylinositol 3-kinase (PI3K) and mTOR complex 2 (mTORC2). mTORC1 inhibitors-rapamycin, temsirolimus, everolimus, and curcumin, mTORC1&mTORC2 inhibitor-INK-128, PI3K&mTOR inhibitor-NVP-BEZ235, and Akt inhibitor-MK-2206-were applied to human disc nucleus pulposus (NP) cells. mTOR signaling, autophagy, apoptosis, senescence, and matrix metabolism were evaluated. RESULTS: mTORC1 inhibitors decreased p70/S6K but increased Akt phosphorylation, promoted autophagy with light chain 3 (LC3)-II increases and p62/sequestosome 1 (p62/SQSTM1) decreases, and suppressed pro-inflammatory interleukin-1 beta (IL-1β)-induced apoptotic terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) positivity (versus rapamycin, 95% confidence interval (CI) -0.431 to -0.194; temsirolimus, 95% CI -0.529 to -0.292; everolimus, 95% CI -0.477 to -0.241; curcumin, 95% CI -0.248 to -0.011) and poly (ADP-ribose) polymerase (PARP) and caspase-9 cleavage, senescent senescence-associated beta-galactosidase (SA-β-gal) positivity (versus rapamycin, 95% CI -0.437 to -0.230; temsirolimus, 95% CI -0.534 to -0.327; everolimus, 95% CI -0.485 to -0.278; curcumin, 95% CI -0.210 to -0.003) and p16/INK4A expression, and catabolic matrix metalloproteinase (MMP) release and activation. Meanwhile, dual mTOR inhibitors decreased p70/S6K and Akt phosphorylation without enhanced autophagy and suppressed apoptosis, senescence, and matrix catabolism. MK-2206 counteracted protective effects of temsirolimus. Additional disc-tissue analysis found relevance of mTOR signaling to degeneration grades. CONCLUSION: mTORC1 inhibitors-notably temsirolimus with an improved water solubility-but not dual mTOR inhibitors protect against inflammation-induced apoptosis, senescence, and matrix catabolism in human disc cells, which depends on Akt and autophagy induction.

  Jun. 2019, Osteoarthritis and cartilage, 27(6) (6), 965 - 976, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Longitudinal Quadriceps Strength Recovery After Anterior Cruciate Ligament Reconstruction With Hamstring Autograft: Patients Stratified by Preoperative Quadriceps Strength Deficit.

  Yuya Ueda, Takehiko Matsushita, Yohei Shibata, Kohei Takiguchi, Akihiro Kida, Daisuke Araki, Noriyuki Kanzaki, Yuichi Hoshino, Rei Ono, Yoshitada Sakai, Ryosuke Kuroda

  CONTEXT: Some studies have discussed postoperative quadriceps strength recovery after anterior cruciate ligament reconstruction (ACLR). However, the effect of preoperative quadriceps strength deficit on longitudinal postoperative quadriceps strength recovery after ACLR with hamstring autograft is unknown. OBJECTIVE: To reveal the longitudinal postoperative quadriceps strength recovery after ACLR with hamstring autograft among patient groups stratified by preoperative quadriceps strength deficit. DESIGN: Retrospective cohort study. SETTING: Single center. PATIENTS: In total, 420 patients (222 men, 218 women; age at the time of surgery 23.1±8.9 years) who underwent ipsilateral ACLR with hamstring autograft, and completed knee function tests preoperatively, and 3, 6, and 12 months postoperatively were included in this study. INTERVENTION: We measured quadriceps strength at 60°/s, tested one-leg hop performance (distance and anxiety), and calculated the quadriceps strength index (QSI) and limb symmetry index (LSI) for one-leg hop distance. Patients were divided into the following four groups according to their preoperative QSI: >80% (Excellent group), 80%-60% (Good group), 60%-40% (Moderate group), and <40% (Poor group). MAIN OUTCOME MEASURES: Postoperative QSI at 3, 6, and 12 months and one-leg hop performance at 12 months after the surgery. RESULTS: The Excellent group had the highest postoperative QSI at all periods. Based on the one-leg hop performance, the Poor group had the lowest LSI and significantly greater anxiety during jump performance in comparison to the Excellent and Good groups. CONCLUSION: The present study shows a longitudinal recovery process and the average postoperative quadriceps strength after ACLR with hamstring autograft in patient groups stratified by preoperative QSI. The results indicate that the difference in preoperative QSI affects not only the longitudinal postoperative QSI recovery but also high-level one-leg hop performance after ACLR using hamstring autograft.

  May 2019, Journal of sport rehabilitation, 29(5) (5), 1 - 20, English, International magazine

  [Refereed]

  Scientific journal


• 内側円板状半月板損傷の1症例

  吉田 慎, 星野 祐一, 置村 健二郎, 三枝 康宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, May 2019, 中部日本整形外科災害外科学会雑誌, 62(3) (3), 585 - 586, Japanese


• 膝関節軟骨穿破を伴ったBrodie膿瘍を長期経過観察した1例

  小原 彬寛, 原 仁美, 河本 旭哉, 川上 洋平, 秋末 敏宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, May 2019, 中部日本整形外科災害外科学会雑誌, 62(3) (3), 599 - 600, Japanese


• 脊椎転移に対する手術療法の効果と限界

  角谷 賢一朗, 酒井 良忠, 由留部 崇, 高田 徹, 張 鍾頴, 宮崎 真吾, 垣内 裕司, 武岡 由樹, 神田 祐太郎, 辻本 龍, 河本 旭哉, 原 仁美, 深瀬 直政, 岡田 卓也, 坂下 明大, 佐々木 良平, 秋末 敏宏, 黒田 良祐, 西田 康太郎

  (一社)日本脊椎脊髄病学会, May 2019, Journal of Spine Research, 10(5) (5), 898 - 904, Japanese


• Accuracy of cup orientation and learning curve of the accelerometer-based portable navigation system for total hip arthroplasty in the supine position.

  Kamenaga T, Hayashi S, Hashimoto S, Matsumoto T, Takayama K, Fujishiro T, Hiranaka T, Niikura T, Kuroda R

  May 2019, Journal of orthopaedic surgery (Hong Kong), 27(2) (2), 2309499019848871

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Topical cutaneous application of CO₂ accelerates bone healing in a rat femoral defect model.

  Kuroiwa Y, Fukui T, Takahara S, Lee SY, Oe K, Arakura M, Kumabe Y, Oda T, Matsumoto T, Matsushita T, Akisue T, Sakai Y, Kuroda R, Niikura T

  BACKGROUND: Bone defects may occur because of severe trauma, nonunion, infection, or tumor resection. However, treatments for bone defects are often difficult and have not been fully established yet. We previously designed an efficient system of topical cutaneous application of carbon dioxide (CO2) using a novel hydrogel, which facilitates CO2 absorption through the skin into the deep area within a limb. In this study, the effect of topical cutaneous application of CO2 on bone healing was investigated using a rat femoral defect model. METHODS: In this basic research study, an in vivo bone defect model, fixed with an external fixator, was created using a rat femur. The affected limb was shaved, and CO2 was applied for 20 min/day, 5 days/week. In the control animals, CO2 gas was replaced with air. Radiographic, histological, biomechanical, and genetic assessments were performed to evaluate bone healing. RESULTS: Radiographically, bone healing rate was significantly higher in the CO2 group than in the control group at 4 weeks (18.2% vs. 72.7%). The degree of bone healing scored using the histopathological Allen grading system was significantly higher in the CO2 group than in the control group at 2 weeks (1.389 ± 0.334 vs. 1.944 ± 0.375). The ultimate stress, extrinsic stiffness, and failure energy were significantly greater in the CO2 group than in the control group at 4 weeks (3.2 ± 0.8% vs. 38.1 ± 4.8%, 0.6 ± 0.3% vs. 41.5 ± 12.2%, 2.6 ± 0.8% vs. 24.7 ± 5.9%, respectively.). The volumetric bone mineral density of the callus in micro-computed tomography analysis was significantly higher in the CO2 group than in the control group at 4 weeks (180.9 ± 43.0 mg/cm3 vs. 247.9 ± 49.9 mg/cm3). Gene expression of vascular endothelial growth factor in the CO2 group was significantly greater than that in the control group at 3 weeks (0.617 ± 0.240 vs. 2.213 ± 0.387). CONCLUSIONS: Topical cutaneous application of CO2 accelerated bone healing in a rat femoral defect model. CO2 application can be a novel and useful therapy for accelerating bone healing in bone defects; further research on its efficacy in humans is warranted.

  May 2019, BMC musculoskeletal disorders, 20(1) (1), 237 - 237, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The Effectiveness and Limitation of Spine Surgery for Spinal Metastasis

  角谷 賢一朗, 酒井 良忠, 由留部 崇, 高田 徹, 張 鍾頴, 宮崎 真吾, 垣内 裕司, 武岡 由樹, 神田 祐太郎, 辻本 龍, 河本 旭哉, 原 仁美, 深瀬 直政, 岡田 卓也, 坂下 明大, 佐々木 良平, 秋末 敏宏, 黒田 良祐, 西田 康太郎

  日本脊椎脊髄病学会, May 2019, Journal of spine research : official journal of the Japanese Society for Spine Surgery and Related Research, 10(5) (5), 898 - 904, Japanese


• 腰、膝の障がいを運動機能から考えてみる 膝関節の障害

  黒田 良祐, 松下 雄彦, 酒井 良忠

  (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), S598 - S598, Japanese


• ICU緊急入室患者の退院時ADLに影響を及ぼす因子についての検討

  松本 健, 原田 理沙, 高宮 大輝, 三浦 靖史, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 3 - 4, Japanese


• 投球動作における肩関節周囲筋組織弾性の経時的変化

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 堯, 向原 伸太郎, 国分 毅, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 333 - 333, Japanese


• プロ野球投手における肩関節コンディションと股関節可動域制限スコアの関係(Hip stiffness score has correlations with range of motion and muscle power of throwing shoulder in professional baseball pitchers)

  美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 国分 毅, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 347 - 347, English


• 高齢者女性におけるロコモスキャンと運動能力の比較

  西本 華子, 乾 淳幸, 美舩 泰, 片岡 武史, 黒澤 尭, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 350 - 350, Japanese


• 若年者の外傷性膝関節脱臼に伴う総腓骨神経麻痺に対して神経移植術を施行した1例

  田中 悟, 乾 淳幸, 向原 伸太郎, 山裏 耕平, 黒澤 堯, 片岡 武史, 西本 華子, 美舩 泰, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 552 - 552, Japanese


• モーションキャプチャセンサによる、手指運動角度の測定

  乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 2 - 6, Japanese


• ACL損傷膝におけるPivot-shift testのEMS計測時の脛骨前後移動の波形解析

  田中 聡一, 星野 祐一, 中西 雄太, 山本 哲也, 寛島 佑史, 山下 貴大, 宮地 伸晃, 荒木 大輔, 松下 雄彦, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 260 - 260, Japanese


• 膝半月板横断裂に対するTie Grip Sutureと新たに開発したCross Tie Grip Sutureの強度比較試験(Biomechanical Evaluation of Cross Tie Grip Suture for Radial Meniscal Tears)

  中西 雄太, 荒木 大輔, 長宗 高樹, 山本 哲也, 神崎 至幸, 星野 祐一, 松下 雄彦, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 300 - 300, English


• Masquelet法により治療したサッカー選手に生じた両恥骨骨髄炎の1例

  村尾 仁美, 荒木 大輔, 松下 雄彦, 星野 祐一, 神崎 至幸, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 362 - 362, Japanese


• 膝前十字靱帯解剖学的二重束再建術におけるOutside-in法とTrans-portal法でのGraft bending angleの比較

  宮地 伸晃, 荒木 大輔, 松下 雄彦, 神崎 至幸, 星野 祐一, 山本 哲也, 中西 雄太, 山下 貴大, 寛島 佑史, 茨木 一行, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 463 - 463, Japanese


• 内反型変形性膝関節症患者における下肢長尺X線像の立位と臥位の違い 高位脛骨骨切り術の術前計画におよぼす影響

  寛島 佑史, 松下 雄彦, 中西 雄太, 山本 哲也, 山下 貴大, 茨木 一行, 宮地 伸晃, 荒木 大輔, 神崎 至幸, 星野 祐一, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 487 - 487, Japanese


• ACL遺残組織温存の賛否 前十字靱帯再建術における遺残組織に含まれる血管由来細胞の治癒能

  松本 知之, 松下 雄彦, 星野 祐一, 荒木 大輔, 美舩 泰, 高山 孝治, 橋本 真吾, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 564 - 564, Japanese


• 電磁気センサーを用いた足関節前方引き出しテストの定量評価法の検証

  山下 貴大, 星野 祐一, 長宗 高樹, 山本 哲也, 宮地 伸晃, 茨木 一行, 田中 聡一, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 698 - 698, Japanese


• 巨大なsubchondral cystを伴う変形性足関節症に対して鏡視下外側靱帯修復術を施行しcystが縮小した1例

  茨木 一行, 神崎 至幸, 山本 哲也, 寛島 佑史, 山下 貴大, 宮地 伸晃, 田中 聡一, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 700 - 700, Japanese


• ラット腱板修復術モデルに対するbFGFおよびPRP同時投与の有効性の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 酒井 良忠, 秋末 敏宏, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 2 - 2, Japanese

  [Refereed]


• がんの骨転移症例に対するリハビリテーション医療の現状と症例検討

  高宮 大輝, 松本 健, 伊達 安理, 仲山 舞, 小林 慶通, 角谷 賢一朗, 原田 理沙, 福田 康治, 原 仁美, 秋末 敏宏, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 1 - 5, Japanese

  [Refereed]


• 心理的リラクセーション効果の視点から見たリウマチ患者に対する音楽療法の効果

  三浦 靖史, 福田 康治, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 3 - 5, Japanese

  [Refereed]


• 【人工膝関節置換術をめぐる議論】後十字靱帯温存型人工膝関節全置換術(CR-TKA)における外側laxityは術後の屈曲可動域に影響を及ぼす因子である

  中野 直樹, 松本 知之, 高山 孝治, 黒田 良祐

  (株)アークメディア, Apr. 2019, Bone Joint Nerve, 9(2) (2), 191 - 195, Japanese


• 【人工膝関節置換術をめぐる議論】Kinematic alignmentの臨床成績 靱帯バランスの影響

  松本 知之, 高山 孝治, 黒田 良祐

  (株)アークメディア, Apr. 2019, Bone Joint Nerve, 9(2) (2), 161 - 166, Japanese


• 【整形外科診療における最先端技術】診断、評価 動的評価 電磁気センサを用いた関節運動の動的評価

  星野 祐一, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (株)南江堂, Apr. 2019, 別冊整形外科, (75) (75), 100 - 103, Japanese


• 【脊椎脊髄外科の最近の進歩】各種疾患に対する治療法・モダリティ 転移性脊椎腫瘍に対する集学的治療

  角谷 賢一朗, 酒井 良忠, 由留部 崇, 張 鐘穎, 黒田 良祐, 西田 康太郎

  金原出版(株), Apr. 2019, 整形・災害外科, 62(5) (5), 567 - 574, Japanese


• Deterioration of patellofemoral cartilage status after medial open-wedge high tibial osteotomy.

  Toshikazu Tanaka, Takehiko Matsushita, Nobuaki Miyaji, Kazuyuki Ibaraki, Kyohei Nishida, Shinya Oka, Daisuke Araki, Noriyuki Kanzaki, Yuichi Hoshino, Tomoyuki Matsumoto, Ryosuke Kuroda

  PURPOSE: To identify parameters associated with deterioration of patellofemoral (PF) cartilage after open-wedge high tibial osteotomy (OWHTO) and determine predictive values. It was hypothesized that cartilage injuries in PF joints would progress after OWHTO in patients who need a large alignment correction. METHODS: Fifty-two knees in 47 patients who underwent bi-planer OWHTO for the treatment of medial compartment osteoarthritis from 2012 to 2017 and received a second-look arthroscopy at the time of plate removal (mean 14 months post-OWHTO) were assessed. Clinical outcomes were evaluated by the Knee Society Scores. Cartilage status in PF joints were evaluated arthroscopically using the International Cartilage Repair Society (ICRS) grading system. Patients were divided into two groups and patients who had progressed PF cartilage injury (progressed group) were compared with those who did not have progressed PF cartilage injuries (non-progressed group) using various parameters. The relationships between medial opening gap or change in the medial proximal tibial angle (ΔmPTA) and progression of PF cartilage injuries were examined by receiver operating characteristic (ROC) curve analysis. RESULTS: The mean Knee Society Scores were significantly improved after surgery (P < 0.01). The grades for the patella and trochlea progressed in 12 (23.0%) and 16 knees (30.8%), respectively. The mean preoperative hip-knee-ankle (HKA) angle, mechanical axis, and mPTA in the progressed group were significantly smaller than those in the non-progressed group (P < 0.01). The mean medial opening gap and ΔmPTA in the progressed group were significantly larger than those in the non-progressed group (P < 0.01). ROC curve analysis showed that the cut-off values of the medial opening gap and ΔmPTA for progression of PF cartilage injuries were 13 mm and 9°, respectively. Progression of PF cartilage injuries was more frequently observed in knees with a medial opening gap ≥ 13 mm (P = 0.019, odds ratio = 4.60) or a ΔmPTA ≥ 9° (P = 0.003, odds ratio 6.93) than knees with those of < 13 mm or 9°, respectively. CONCLUSIONS: Cartilage injuries in PF joints tended to progress after OWHTO in patients with medial opening gap ≥ 13 mm or ΔmPTA ≥ 9°. If medial opening gap is ≥ 13 mm or ΔmPTA is ≥ 9° in planning for OWHTO, other type of surgery may need to be considered to avoid early progression of PF cartilage injuries. LEVEL OF EVIDENCE: Level IV, therapeutic case series.

  Apr. 2019, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 27(4) (4), 1347 - 1354, English, International magazine

  [Refereed]

  Scientific journal


• 【人工膝関節置換術をめぐる議論】Kinematic alignmentの臨床成績 靱帯バランスの影響

  松本 知之, 高山 孝治, 黒田 良祐

  (株)アークメディア, Apr. 2019, Bone Joint Nerve, 9(2) (2), 161 - 166, Japanese


• 【人工膝関節置換術をめぐる議論】後十字靱帯温存型人工膝関節全置換術(CR-TKA)における外側laxityは術後の屈曲可動域に影響を及ぼす因子である

  中野 直樹, 松本 知之, 高山 孝治, 黒田 良祐

  (株)アークメディア, Apr. 2019, Bone Joint Nerve, 9(2) (2), 191 - 195, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  平田 悠, 野村 和弘, 小林 憲太, 岡本 士毅, 箕越 靖彦, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 細岡 哲也, 小川 渉

  日本臨床分子医学会, Apr. 2019, 日本臨床分子医学会学術総会プログラム・抄録集, 56回, 71 - 71, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  平田 悠, 野村 和弘, 千賀 陽子, 岡田 裕子, 小林 憲太, 岡本 士毅, 箕越 靖彦, 今村 道博, 武田 伸一, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 細岡 哲也, 小川 渉

  (一社)日本糖尿病学会, Apr. 2019, 糖尿病, 62(Suppl.1) (Suppl.1), S - 149, Japanese


• 三次元電磁気センサーを用いた肘関節可動域の定量評価法の開発

  山裏 耕平, 乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 向原 伸太郎, 国分 毅, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), O2 - 5, Japanese


• ジャイロセンサを利用した、ウエラブル上肢運動モニタリングシステムの開発

  乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), P1 - 2, Japanese


• モーションキャプチャーセンサを使用した手指外転角度の測定

  乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), P1 - 3, Japanese


• 三次元電磁気センサを使用した前腕回旋運動の定量的評価の試み

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), P1 - 5, Japanese


• 神経損傷後の骨格筋不動化による筋萎縮・脂肪細胞浸潤と脂肪組織炎症の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 国分 毅, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), BP2 - 6, Japanese


• 三次元電磁気センサーを用いた肘関節可動域の定量評価法の開発

  山裏 耕平, 乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 向原 伸太郎, 国分 毅, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), O2 - 5, Japanese


• ジャイロセンサを利用した、ウエラブル上肢運動モニタリングシステムの開発

  乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), P1 - 2, Japanese


• モーションキャプチャーセンサを使用した手指外転角度の測定

  乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), P1 - 3, Japanese


• 三次元電磁気センサを使用した前腕回旋運動の定量的評価の試み

  向原 伸太郎, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 長宗 高樹, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), P1 - 5, Japanese


• 神経損傷後の骨格筋不動化による筋萎縮・脂肪細胞浸潤と脂肪組織炎症の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 国分 毅, 黒田 良祐

  (一社)日本手外科学会, Apr. 2019, 日本手外科学会雑誌, 36(1) (1), BP2 - 6, Japanese


• 骨釘による指関節固定を行った化膿性DIP関節炎の2例

  中林 大治, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(2) (2), 225 - 226, Japanese


• 軟骨損傷を伴った習慣性膝蓋骨脱臼に対して脛骨粗面前内方近位移行および内側膝蓋大腿靱帯再建術にて良好な成績を得た1例

  渡邉 秀, 荒木 大輔, 松下 雄彦, 神崎 至幸, 松本 知之, 高山 孝治, 黒田 良祐

  (株)メジカルビュー社, Mar. 2019, 関節外科, 38(3) (3), 330 - 335, Japanese


• 手根管症候群の母指球筋萎縮に対する肉眼的評価と超音波検査による評価の対比

  名倉 一成, 金谷 貴子, 原田 義文, 鷲見 正敏, 乾 淳幸, 美舩 泰, 黒田 良祐

  (株)医学書院, Mar. 2019, 臨床整形外科, 54(3) (3), 285 - 288, Japanese


• PS型人工膝関節全置換術における術後1年の患者満足度に及ぼす術後早期膝安定性の影響

  澤内 健一, 村津 裕嗣, 尾ノ井 勇磨, 渡邊 秀, 神村 真人, 大島 隆司, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2019, JOSKAS, 44(1) (1), 186 - 187, Japanese


• 整形外傷領域における再生医療

  新倉 隆宏, 松本 知之, 美舩 泰, 福井 友章, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S113 - S113, Japanese


• 手根管症候群における超音波検査を用いた母指球筋の質的評価

  名倉 一成, 金谷 貴子, 原田 義文, 鷲見 正敏, 乾 淳幸, 美舩 泰, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S254 - S254, Japanese


• 医学部5年次bed side learningにおけるシリコン製スポンジを用いた腱縫合実習

  乾 淳幸, 美舩 泰, 西本 華子, 黒澤 尭, 片岡 武史, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S297 - S297, Japanese


• スポーツ選手・愛好家における自家培養軟骨移植術の術後臨床成績

  荒木 大輔, 松下 雄彦, 星野 祐一, 神崎 至幸, 黒田 良祐

  (一社)日本移植学会, Mar. 2019, 移植, 53(6) (6), 381 - 381, Japanese


• 大腿骨遠位骨切り術および高位脛骨骨切り術(Double-level osteotomy)後に発生したCheckrein変形の一例

  安部 真人, 松下 雄彦, 神崎 至幸, 荒木 大輔, 星野 祐一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(春季学会) (春季学会), 228 - 228, Japanese


• 人工足関節置換術(TAA)における距骨コンポーネント設置位置が術後の沈下量に及ぼす影響についての検討

  山本 哲也, 神崎 至幸, 山下 貴大, 茨木 一行, 宮地 伸晃, 田中 聡一, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(3) (3), S727 - S727, Japanese


• 人工足関節置換術後における脛骨・距骨componentの設置角度のX線学的検討

  山本 哲也, 神崎 至幸, 山下 貴大, 茨木 一行, 宮地 伸晃, 田中 聡一, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(3) (3), S728 - S728, Japanese


• 異なる2つの面による膝前十字靱帯解剖学的二重束再建術後の脛骨骨孔評価

  山本 哲也, 荒木 大輔, 宮地 伸晃, 山下 貴大, 茨木 一行, 田中 聡一, 神崎 至幸, 星野 祐一, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S165 - S165, Japanese


• ACL再建術の基礎と臨床 ACL再建術の向上を目指したpivot-shiftを定量的に評価するための基礎研究と臨床応用

  星野 祐一, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S324 - S324, Japanese


• 膝前十字靱帯損傷の治療戦略

  黒田 良祐, 松下 雄彦, 星野 祐一, 荒木 大輔

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S325 - S325, Japanese


• 変形性足関節症に対する治療戦略 人工足関節置換術の適応と手術成績

  神崎 至幸, 山本 哲也, 山下 貴大, 茨木 一行, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S433 - S433, Japanese


• リハビリテーション リウマチ患者に対する音楽療法 心理的リラクセーション効果の検討

  三浦 靖史, 山崎 郁子, 雄鹿 賢哉, 福田 康治, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2019, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 441 - 441, Japanese

  [Refereed]


• 関節リウマチの治療評価と予測-3 ゲノムワイドSNP解析によるトシリズマブの治療有効性と二次無効の予測

  亀長 智幸, 林 申也, 福田 康治, 高島 良典, 黒田 良祐, 橋本 麿和, 舟橋 恵子, 松原 司

  (一社)日本リウマチ学会, Mar. 2019, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 517 - 517, Japanese

  [Refereed]


• FasLはリウマチ滑膜線維芽細胞における様々な遺伝子の発現を制御する

  福田 康治, 三浦 靖史, 前田 俊恒, 林 申也, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2019, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 603 - 603, Japanese

  [Refereed]


• TNF阻害薬による関節リウマチ滑膜組織の組織学的変化の検討

  高島 良典, 福田 康治, 林 申也, 亀長 智幸, 黒田 良祐, 橋本 麿和, 舟橋 恵子, 松原 司

  (一社)日本リウマチ学会, Mar. 2019, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 605 - 605, Japanese

  [Refereed]


• RA患者における関節破壊の特徴によるトシリズマブ有効性の検討

  林 申也, 松原 司, 福田 康治, 舟橋 恵子, 橋本 麿和, 亀長 智幸, 高島 良典, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2019, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 618 - 618, Japanese

  [Refereed]


• リウマチ用水銀握力計の代替握力計に関する検討

  三浦 靖史, 福田 康治, 柴沼 均, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2019, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 670 - 670, Japanese

  [Refereed]


• 多施設コホートを用いたイグラチモドの治療継続率

  福田 康治, 松原 司, 舟橋 恵子, 橋本 麿和, 林 申也, 亀長 智幸, 高島 良典, 酒井 良忠, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2019, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 682 - 682, Japanese

  [Refereed]


• 巨大なsubchondral cystを伴う変形性足関節症に対する治療経験

  茨木一行, 神崎至幸, 中西雄太, 山本哲也, 寛島佑史, 山下貴大, 宮地伸晃, 田中聡一, 星野祐一, 松下雄彦, 黒田良祐

  関西関節鏡・膝研究会, Mar. 2019, 関西関節鏡・膝研究会プログラム・演題抄録 31回, 31回, 28 - 28, Japanese

  Research society


• ACL再建術の現状と展望 膝関節不安定性の定量的評価に基づいたACL再建術の改良

  星野祐一, 神崎至幸, 松下雄彦, 黒田良祐

  関西関節鏡・膝研究会, Mar. 2019, 関西関節鏡・膝研究会プログラム・演題抄録 31回, 31回, 44 - 44, Japanese

  Research society


• Prediction of quadriceps strength recovery after anterior cruciate ligament reconstruction with a hamstring autograft: Decision tree analysis.

  Yohei Shibata, Takehiko Matsushita, Daisuke Araki, Akihiro Kida, Kohei Takiguchi, Yuya Ueda, ONO KUMIKO, Tomoyuki Matsumoto, Takahiro Niikura, Yoshitada Sakai, Ryosuke Kuroda

  BACKGROUND: The wide variations in patient demographics and concomitant injuries make the prediction of which patients will regain strength quickly following anterior cruciate ligament (ACL) reconstruction challenging. This study aimed to identify the dominant factor affecting quadriceps strength recovery after ACL reconstruction with a hamstring tendon autograft and to construct a predictive model for quadriceps strength recovery using decision tree analysis. METHODS: Three hundred and eighty-six patients who underwent ACL reconstruction with a hamstring tendon autograft were included in this study. The isokinetic quadriceps strength at 60°/s was measured preoperatively and at 6 months after surgery. The quadriceps strength index (QSI) was calculated by normalising the peak torque of the involved leg with the uninvolved leg and multiplying it by 100. A stepwise multiple linear regression and a decision tree analysis were performed to assess whether or not the following parameters affect quadriceps strength recovery at 6 months: socio-demographic data and maximum isokinetic quadriceps strength. RESULTS: The preoperative QSI, age, and pre-injury Tegner activity scale were independently correlated with quadriceps strength recovery at 6 month after surgery. The decision tree analysis demonstrated that patients were expected to have a QSI ≥85% at 6 months after surgery if they met one of the following conditions: (1) age <23 years with a preoperative QSI ≥78.8%, (2) age ≥29 years with a preoperative QSI ≥98.0%, or (3) age <16 years with a preoperative QSI <58.5% and pre-injury Tegner activity scale ≥9. By contrast, patients ≥29 years with a preoperative QSI <98.0% were likely to achieve a quadriceps strength index <70% at 6 months after surgery. CONCLUSIONS: Based on the results of the decision tree analysis, younger patients could achieve good quadriceps recovery even if they have a lower preoperative QSI, whereas patients ≥29 years need a higher preoperative QSI to obtain good muscle recovery.

  Mar. 2019, J Orthop Sci., 24(2) (2), 301 - 305, English, Domestic magazine

  [Refereed]

  Scientific journal


• Molecular changes to tendons after collagenase-induced acute tendon injury in a senescence-accelerated mouse model

  Ueda Y, Inui A, Mifune Y, Takase F, Kataoka T, Kurosawa T, Yamaura K, Kokubu T, Kuroda Ryosuke

  BACKGROUND: Aging impairs tendon healing and is a potential risk factor for chronic tendinitis. During normal aging, tendons undergo structural and biomechanical degenerative changes, accompanied by a reduction in the number of tenocytes and changes to their properties. However, molecular changes in aged tendons under inflammatory conditions are not well understood. The present study analyzed the molecular changes in collagenase induced acute tendon injury using a senescence-accelerated mouse (SAM) model. METHODS: SAMP6 mice were used as an aging animal model and SAMR1 mice were used as a control to represent a senescence-resistant inbred strain. All the mice used in the study were 40 weeks old. Collagenase I from Clostridium histolyticum (20 μL) was injected percutaneously to the tendon-bone junction of the Achilles tendon. Two weeks after treatment, the Achilles tendons were harvested and stained using Picrosirius Red to determine collagen expression. Real-time PCR was performed to analyze gene expression of IL-6, tenomodulin, type I and type II collagen, MMP-9, TIMP-1, and TIMP-2. RESULTS: Collagenase injection resulted in significantly higher gene expression of IL-6 but significantly lower tenomodulin expression compared with the control in SAMP6 and SAMR1 mice. In SAMP6 mice, gene expression of type III collagen and MMP-9 was significantly higher in the collagenase-injected group compared with the control group. SAMP6 mice also showed lower expression of type I collagen, TIMP-1, and TIMP-2 in the collagenase-injected group compared with the control group. Picrosirius Red staining showed the highest expression of type III collagen in the collagenase-injected SAMP6 group compared with the other groups. CONCLUSIONS: The collagenase-injected SAMP6 group showed higher expression of IL-6, MMP-9, and type III collagen and lower expression of type I collagen, TIMP-1, and TIMP-2, which are known to suppress metalloproteinases. The results indicate that aging may lead to dysfunction of the tendon healing process after acute tendon injury.

  Mar. 2019, BMC Musculoskelet Disord, 20(1) (1), 120 - 120, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Attenuation of osteoarthritis progression in mice following intra-articular administration of simvastatin-conjugated gelatin hydrogel

  Toshikazu Tanaka, Takehiko Matsushita, Kyohei Nishida, Koji Takayama, Kanto Nagai, Daisuke Araki, Tomoyuki Matsumoto, Yasuhiko Tabata, Ryosuke Kuroda

  Mar. 2019, Journal of Tissue Engineering and Regenerative Medicine, 13(3) (3), 423 - 432, English

  [Refereed]

  Scientific journal


• 胸腰椎椎体骨折におけるTrabecular Bone Score(TBS)とBone Mineral Density(BMD)とFRAXの骨折予測因子としての可能性 TBSの骨折予測因子としての働き

  西本 華子, 乾 淳幸, 美舩 泰, 新倉 隆宏, 楊 鴻生, 鷲見 正敏, 黒田 良祐

  (一社)日本骨粗鬆症学会, Feb. 2019, 日本骨粗鬆症学会雑誌, 5(1) (1), 140 - 146, Japanese


• Shear Wave Elastographyを用いた投球動作による前腕屈筋群の組織弾性変化についての検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 山裏 耕平, 向原 伸太郎, 国分 毅, 黒田 良祐

  日本肘関節学会, Feb. 2019, 日本肘関節学会雑誌, 26(1) (1), S127 - S127, Japanese


• The concomitant lateral meniscus injury increased the pivot shift in the anterior cruciate ligament-injured knee.

  Yuichi Hoshino, Nobuaki Miyaji, Kyohei Nishida, Yuichiro Nishizawa, Daisuke Araki, Noriyuki Kanzaki, Kenichiro Kakutani, Takehiko Matsushita, Ryosuke Kuroda

  PURPOSE: Concomitant meniscus injuries in the anterior cruciate ligament (ACL) have been suggested to exacerbate rotational laxity. However, the effect is supposed to be so small, if any, that some quantitative pivot-shift measurement is needed. The purpose of this prospective study was to determine the effect of meniscus tear on rotational laxity in ACL-deficient knees by an quantitative measurement. It was hypothesized that a concomitant meniscus tear, especially a lateral one, would induce greater pivot shift. METHODS: Fifty-seven unilateral ACL-injured patients (26 men and 31 women, mean age: 24 ± 10 years) were included. The pivot-shift test was performed prior to ACL reconstruction, while a quantitative evaluation using an electromagnetic system to determine tibial acceleration and a clinical grading according to the IKDC were performed. Meniscus injuries were diagnosed arthroscopically, and concomitant meniscus tear was confirmed in 32 knees. RESULTS: The clinical grade was not different between the ACL-injured knees of patients with and without meniscus tear (n.s.). Tibial acceleration did not show a statistical significant difference (meniscus-injured knees: 1.6 ± 1.1 m/s2 versus meniscus-intact knees: 1.2 ± 0.7 m/s2, n.s.). However, the subgroup analysis demonstrated that there was increased tibial acceleration in ACL-deficient knees with lateral meniscus tear (2.1 ± 1.1 m/s2, n = 13) compared with meniscus-intact knees (p < 0.05), whereas rotational laxity did not increase in the medial meniscus-injured and bilateral-injured knees (1.2 ± 0.9 m/s2, n = 12, n.s. and 1.4 ± 1.1 m/s2, n = 7, n.s., respectively). CONCLUSION: A concomitant meniscus tear, especially a lateral meniscus tear, has a significant impact on rotational laxity in ACL-injured knees. When a large pivot shift is observed in the ACL-injured knee, a concomitant meniscus tear should be suspected and an aggressive treatment would be considered. Meniscus injuries should be inspected carefully when substantial pivot shift is encountered in ACL-injured knees. LEVEL OF EVIDENCE: Diagnostic study, Level III.

  Feb. 2019, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 27(2) (2), 646 - 651, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Possible Improvement of the Sagittal Spinopelvic Alignment and Balance through "Locomotion Training" Exercises in Patients with "Locomotive Syndrome": A Literature Review.

  Takashi Yurube, Masaaki Ito, Toru Takeoka, Nobuyoshi Watanabe, Hideyo Inaoka, Kenichiro Kakutani, Ryosuke Kuroda, Kotaro Nishida

  On the basis of rapid population aging, in 2007, the Japanese Orthopaedic Association (JOA) proposed a new disease concept "locomotive syndrome" as a degenerative condition of reduced mobility due to the impairment of the musculoskeletal system. Worsened locomotive components, which consist of bones, joints, and intervertebral discs, and muscles and nerves, can lead to symptoms such as pain, limited range of motion, malalignment, impaired balance, and difficulty in walking, ultimately resulting in the requirement of nursing care. "Locomotive syndrome" has gained increased interest in Japan but still not worldwide. Hence, in this brief review, we summarize an updated definition, assessment, and management of "locomotive syndrome". The JOA recommends "locomotion training" exercise intervention to be effective in maintaining motor function that comprises two simple exercises-squatting and single-leg standing. However, the extent to which exercises affect "locomotive syndrome" is unknown. Here, we further report hypothesis-generating patient cases who presented the improved sagittal spinopelvic alignment in standing radiographs and postural stability in piezoelectric force-plate measurements through our 6-month "locomotion training" outpatient rehabilitation program. It is noteworthy that "locomotion training" facilitated these improvements despite the presence of specific disorders including thoracic kyphosis and symptomatic lumbar spinal canal stenosis. This raises the need for further investigations to clarify effects of "locomotion training" exercises on the spinal alignment, global balance, and quality of life in patients with "locomotive syndrome".

  2019, Advances in orthopedics, 2019, 6496901 - 6496901, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• A Periprosthetic Femoral Fracture with Characteristics of Atypical Femoral Fracture.

  Shuya Tanaka, Tomoaki Fukui, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Shinya Hayashi, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Although the definition of atypical femoral fracture (AFF) excludes periprosthetic femoral fracture (PFF), the number of reports about PFF with characteristics of AFF is increasing. We present the case of such a fracture in this report. An 87-year-old woman who underwent bipolar hip arthroplasty for a femoral neck fracture 38 months prior reported left thigh pain with no history of trauma. Radiographs showed a simple transverse fracture at the level of the stem distal end with features of AFF: periosteal thickening of the lateral cortex, a medial spike, and a noncomminuted fracture. She presented other features resembling AFF: history of bisphosphonate use, prodromal symptoms, no associated trauma, and lateral bowing of the contralateral femur. The fracture showed nonunion after the initial osteosynthesis, and a revision surgery of the arthroplasty and osteosynthesis was performed. Nine months after the surgery, bony union was achieved and she regained the ability to walk. It is supposed that the fracture was influenced by a stress force related to implants and lateral bowing concentrating on the fracture site as a mechanical factor in addition to bisphosphonates as a biological factor. It would be important to recognize that AFF could occur at the peri-implant location, and early detection and treatment are essential.

  2019, Case reports in orthopedics, 2019, 1275369 - 1275369, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Recurrent Hematomas following a Revision Total Hip Arthroplasty in Acquired Coagulation Factor XIII Deficiency.

  Takashima Y, Hashimoto S, Kamenaga T, Tsubosaka M, Kuroda Y, Takeuchi K, Takayama K, Hayashi S, Kuroda R, Matsumoto T

  Coagulation factor XIII (FXIII) is the final enzyme in the coagulation cascade and plays an important role in catalyzing the intermolecular cross-linking of fibrin polymers. FXIII deficiency is a rare disorder that presents with recurrent soft tissue bleeding. In this case report, we describe a patient with recurrent hematomas, following a revision total hip arthroplasty (THA). A 50-year-old female patient with no past history of bleeding and with a normal perioperative coagulation profile presented with recurrent hip joint hematomas. Her plasma FXIII activity showed a slight decrease (69%). Therefore, the patient was diagnosed with an acquired deficiency and was administered FXIII to correct it. The bleeding did not recur once the FXIII activity had returned to a normal level (76%). At 2 months after the second evacuation procedure, the patient was discharged from the hospital in an ambulatory state. There has been no recurrence of a hematoma since. We managed a rare case of acquired FXIII deficiency, which highlighted that a patient can present with an acquired bleeding disorder despite having a normal coagulation profile. An acquired FXIII deficiency should be suspected in patients with inexplicable, sudden-onset bleeding, as early diagnosis and treatment are important to prevent life-threatening complications.

  2019, Case reports in orthopedics, 2019, 4038963 - 4038963, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Humeral Shaft Non-union in a Patient with Osteogenesis Imperfecta Treated with Mandible Locking Plate Fixation: A Case Report.

  Sano S, Oe K, Fukui T, Hayashi S, Kuroda R, Niikura T

  Introduction: Osteogenesis imperfecta (OI) is a heritable disorder of connective tissue. Due to poor bone quality, patients with OI develop bone fracture and subsequent non-union at high rates. We report the rare case of humeral shaft non-union successfully treated by a locking plate used formandibular bone in a patient with OI. Case Report: A 26-year-old man with Type III OI and a history of corrective osteotomy with Kirschner wire fixation of his right humerus at the age of 8 years developed gradually increasing pain in his humerus. He sustained humeral shaft non-union due to a broken Kirschner wire used in the previous operation and was referred to our hospital. He underwent internal fixation using an elastic nail with an iliac bone graft. However, 2 years after the operation, bony union was not achieved due to elastic nail breakage, and he complained of pain and activity limitation. He underwent re-operation for the humeral non-union using a locking plate to achieve rigid fixation. Because his humeral shaft was extremely narrow with severe deformity, we used a locking plate for the mandibular bone, which was contoured to fit the medial side of the humeral shaft. Bony union was achieved, the pain was relieved, and the patient returned to his pre-injury activity with no symptoms.4years after the operation, a new fracture line was found in radiographs of the distal part of the non-union. Bony union was achieved by conservative treatment. At present, the function has recovered. Conclusion: Humeral non-union in this patient with OI was successfully treated by a mandible locking plate. Although the optimal fixation device for fractures or non-unions in patients with OI has not yet been established, this plate could be a good treatment option for narrow and severely deformed bone.

  2019, Journal of orthopaedic case reports, 9(3) (3), 19 - 21, English, International magazine

  [Refereed]


• Trapezoid Fracture Associated with Scaphoid Fracture in a Football Goalkeeper.

  Yamamoto T, Matsushita T, Ito K, Matsushima S, Yoshida K, Kuroda R

  2019, Case reports in orthopedics, 2019, 7949754

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• An objective indicator focused on the symmetrical movements of the arms to assess gait stability

  Yuki Azuma, Kouki Nagamune, Ryosuke Kuroda

  Fuji Technology Press, 2019, Journal of Advanced Computational Intelligence and Intelligent Informatics, 23(4) (4), 767 - 774, English

  Scientific journal


• 成長期の膝スポーツ傷害に対する治療 前十字靱帯損傷(2)

  岡 真也, 山口 基, 松本 彰生, 大西 慎太郎, 松下 雄彦, 黒田 良祐

  スポーツ傷害フォーラム, 2019, スポーツ傷害, 24, 47 - 47, Japanese


• A case of a painful coalition between pisiform and hamate.

  Atsuyuki Inui, Yutaka Mifune, Hanako Nishimoto, Takahiro Niikura, Ryosuke Kuroda

  We report a case of the pisiform and hamate coalition in 13-years-old male. Interoperative findings revealed that the ulnar nerve runs over the hook of the hamate which is the nonanatomic site. Surgical resection of pisiform relieved the pain.

  2019, Case reports in plastic surgery & hand surgery, 6(1) (1), 35 - 37, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 少年サッカーチームにおけるスポーツ外傷・障害の調査 保護者アンケートによる調査

  茨木 一行, 松下 雄彦, 中西 雄太, 山本 哲也, 山下 貴大, 寛島 佑史, 宮地 伸晃, 田中 聡一, 荒木 大輔, 星野 祐一, 神崎 至幸, 黒田 良祐

  スポーツ傷害フォーラム, 2019, スポーツ傷害, 24, 30 - 30, Japanese


• Analysis of anterior tibial subluxation to the femur at maximum extension in anterior cruciate ligament-deficient knees

  Nishida K, Matsushita T, Araki D, Sasaki H, Tanaka T, Hoshino Y, Kanzaki Noriyuki, Matsumoto Tomoyuki, Nagamune K, Niikura Takahiro, Kurosaka M, Kuroda Ryosuke

  Jan. 2019, J Orthop Surg (Hong Kong), 27(1) (1), 2309499019833606, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• エイジングによる骨脆弱化と脊柱変形に対する対策 多職種連携による骨粗鬆症外来と今後の展望 骨粗鬆症リエゾンサービスの挑戦

  西本 華子, 楊 鴻生, 鷲見 正敏, 黒田 良祐

  (株)メディカルレビュー社, Dec. 2018, Anti-aging Science, 10(1) (1), 87 - 87, Japanese


• 関節リウマチ患者に対するTNF阻害薬の10年を超える治療継続率の比較

  黒田 良祐, 福田 康治, 林 申也, 舟橋 恵子, 松原 司, 橋本 麿和, 奥田 康介, 堤 聡, 冨田 大介, 伊丹 哲, 酒井 良忠, 三浦 靖史

  (一社)日本臨床リウマチ学会, Dec. 2018, 臨床リウマチ, 30(4) (4), 269 - 275, Japanese

  [Refereed]


• Anatomic Anterior Cruciate Ligament Reconstruction Using Hamstring Tendons Restores Quantitative Pivot Shift.

  Stefano Zaffagnini, Cecilia Signorelli, Alberto Grassi, Yuichi Hoshino, Ryosuke Kuroda, Darren de Sa, David Sundemo, Kristian Samuelsson, Volker Musahl, Jon Karlsson, Andrew Sheean, Jeremy M Burnham, Jayson Lian, Clair Smith, Adam Popchak, Elmar Herbst, Thomas Pfeiffer, Paulo Araujo, Alicia Oostdyk, Daniel Guenther, Bruno Ohashi, James J Irrgang, Freddie H Fu, Kouki Nagamune, Masahiro Kurosaka, Giulio Maria Marcheggiani Muccioli, Nicola Lopomo, Federico Raggi, Eleonor Svantesson, Eric Hamrin Senorski, Haukur Bjoernsson, Mattias Ahlden, Neel Desai

  Background: It is still uncertain how surgical reconstruction of the anterior cruciate ligament (ACL) is able to restore rotatory laxity of the involved joint. The desired amount of restraint applied by the ACL graft, as compared with the healthy knee, has not been fully clarified. Purpose: To quantify the ability of single-bundle anatomic ACL reconstruction using hamstring tendons in reducing the pivot-shift phenomenon immediately after surgery under anesthesia. Study Design: Case series; Level of evidence, 4. Methods: An inertial sensor and image analysis were used at 4 international centers to measure tibial acceleration and lateral compartment translation of the knee, respectively. The standardized pivot-shift test was quantified in terms of the side-to-side difference in laxity both preoperatively and postoperatively with the patient under anesthesia. The reduction in both tibial acceleration and lateral compartment translation after surgery and the side-to-side difference were evaluated using the Wilcoxon signed-rank test. Alpha was set at P < .05. Results: A total of 107 patients were recruited for the study, and data were available for 89 patients. There was a statistically significant reduction in quantitative rotatory knee laxity between preoperatively (inertial sensor, 2.55 ± 4.00 m/s2; image analysis, 2.04 ± 2.02 mm) and postoperatively (inertial sensor, -0.54 ± 1.25 m/s2; image analysis, -0.10 ± 1.04 mm) between the involved and healthy joints, as measured by the 2 devices (P < .001 for both). Postoperatively, both devices detected a lower rotatory laxity value in the involved joint compared with the healthy joint (inertial sensor, 2.45 ± 0.89 vs 2.99 ± 1.10 m/s2, respectively [P < .001]; image analysis, 0.99 ± 0.83 vs 1.09 ± 0.92 mm, respectively [P = .38]). Conclusion: The data from this study indicated a significant reduction in the pivot shift when compared side to side. Both the inertial sensor and image analysis used for the quantitative assessment of the pivot-shift test could successfully detect restoration of the pivot shift after anatomic single-bundle ACL reconstruction. Future research will examine how pivot-shift control is maintained over time and correlation of the pivot shift with return to full activity in patients with an ACL injury.

  Dec. 2018, Orthopaedic journal of sports medicine, 6(12) (12), 2325967118812364 - 2325967118812364, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Olecranon Apophyseal Nonunion in Adolescent Judo Players: A Report of Two Cases

  Yamaura K, Mifune Yutaka, Inui A, Nishimoto H, Ueda Y, Kataoka T, Kurosawa T, Mukohara S, Kokubu T, Kuroda Ryosuke

  Olecranon apophyseal nonunion is an elbow injury from overuse that affects adolescent athletes such as baseball pitchers who participate in overhead throwing sports. However, such injury is rare in collision sports. Here, we report two patients with this condition who are Judo athletes. The purpose of this report was to describe three elbows with olecranon apophyseal nonunion in two adolescent patients participating in Judo. This is a case series; the level of evidence is 4. Two 15-year-old patients were evaluated. One suffered from unilateral and the other from bilateral chronic posterior elbow pain. They were diagnosed with olecranon apophyseal nonunion, which was treated using internal fixation and bone grafting. Radiographic evidence of the apophyseal union was observed four months postsurgery. Two elbows were treated with tension band wiring, then they underwent hardware removal six months postsurgery. Both patients returned to their previous levels of activities six months postsurgery. Internal fixation using autologous bone grafting was a useful treatment for these Judo athletes with olecranon apophyseal nonunion.

  Dec. 2018, Case Rep Orthop, 2018, 8256074 - 8256074, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Influence of limb alignment and prosthetic orientation on patient-reported clinical outcomes in total knee arthroplasty

  Kuroda Y, Takayama Kouji, Ishida K, Hayashi Shinya, Hashimoto Shingo, Nishida K, Matsushita T, Niikura Takahiro, Kuroda Ryosuke, Matsumoto Tomoyuki

  BACKGROUND: The relationship between postoperative limb alignment and clinical outcomes in primary total knee arthroplasty (TKA) is well reported, but the instruments used to evaluate clinical outcomes of TKA are mainly scoring systems from the physician's viewpoint, not patient-reported outcomes. The purpose of this study was to investigate retrospectively the relationship between postoperative limb alignment and patient-reported clinical outcomes using the 2011 Knee Society Knee Scoring System (2011 KSS). METHODS: The present study included 155 knees of patients (median age, 74 years) who underwent primary TKA for varus osteoarthritis, with a mean follow-up period of 46 months. The subjects were divided into three groups based on postoperative limb alignment and femoral and tibial component positioning angle (varus, neutral, and valgus). The 2011 KSS scores were compared among the groups. RESULTS: For limb alignment, the postoperative objective knee indicator score was significantly lower in the valgus group than in the varus and neutral groups, whereas no significant differences were observed in any subjective categories of the 2011 KSS. However, for the femoral component angle, functional activity scores were significantly lower in the valgus group than in the varus and neutral groups. CONCLUSIONS: The subjective patient-reported score was not affected by the postoperative limb alignment. However, the valgus femoral component angle resulted in lower subjective functional scores. For clinical relevance, postoperative valgus positioning of femoral component should be avoided from patient-reported functional aspects during TKA.

  Dec. 2018, J Orthop Sci, 24(4) (4), 668 - 673, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effect of intraoperative soft tissue balance on postoperative recovery of ambulatory and balancing function in posterior-stabilized total knee arthroplasty

  Tsubosaka M, Muratsu H, Takayama Kouji, Maruo A, Miya H, Kuroda Ryosuke, Matsumoto Tomoyuki

  BACKGROUND: The effectiveness of total knee arthroplasty (TKA) on ambulatory and balancing function recovery should be quantitatively investigated. The present study aimed to evaluate ambulatory function using 3m-timed up and go (TUG) test and balancing function using one-leg standing time (ST) from before and after TKA, and to analyze the effects of intraoperative soft tissue balance on the postoperative improvement of their functions after TKA. METHODS: The study included 65 patients with varus-type knee osteoarthritis who underwent primary posterior-stabilized (PS) TKA. The TUG test and ST were performed preoperatively, 1 month and 12 months after TKA. The intraoperative soft tissue balance, medial and lateral joint looseness (MJL, LJL) were evaluated with both femoral trial in place and patellofemoral joint reduced using the OFR tensor® with the knee at 0, 10, 30, 45, 60, 90, 120, and 135°. The influences of MJL and LJL on the improvement in TUG test time and ST and the 2011 Knee Society Knee Scoring System (2011 KSS) 12 months after TKA were investigated. RESULTS: The mean TUG test times and ST were 12.7 and 13.1, 13.5 and 15.4, and 10.9 and 19.2 s preoperatively, 1 month and 12 months after TKA, respectively. The MJL at 10, 30 and 90° flexion was significantly negatively correlated with improvement in the TUG test time and the MJL at 0° flexion was significantly negatively correlated with improvement in the ST. However, the LJL was not significantly correlated with improvement in the TUG test time and the ST. The MJL at 45, 60, and 90° flexion was significantly negatively correlated with the 12-month postoperative score on the activities subscale of the 2011 KSS. CONCLUSIONS: The higher intraoperative medial knee stability may be associated with the better postoperative improvement in ambulatory function and activities subscale of the 2011 KSS after PS-TKA.

  Dec. 2018, J Orthop Sci, 24(3) (3), 507 - 513, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Cyclin-Dependent Kinase Inhibitor-1-Deficient Mice Are Susceptible to Osteoarthritis Associated With Enhanced Inflammation

  KiharaS, Hayashi Shinya, Hashimoto Shingo, Kanzaki Noriyuki, Takayama Kouji, Matsumoto Tomoyuki, ChinzeiN, IwasaK, HanedaM, TakeuchiK, Nishida Kotaro, Kuroda Ryosuke

  Dec. 2018, J Bone Miner Res, 33(12) (12), 2242 - 2242, English, International magazine

  [Refereed]

  Scientific journal


• Case Series of Comminuted Olecranon Fracture Treated by Plate Fixation; Do We Have to Remove the Plate?

  Atsuyuki Inui, Tsukasa Kuroda, Takashi Kurosawa, Takeshi Kokubu, Yutaka Mifune, Hanako Nishimoto, Ryosuke Kuroda

  NLM (Medline), Nov. 2018, The Kobe journal of medical sciences, 64(3) (3), E115 - E118, English

  Scientific journal


• Biological Treatment of Intervertebral Disc Degeneration : autophagy

  由留部 崇, 伊藤 雅明, 垣内 裕司, 角谷 賢一朗, 高田 徹, 武岡 由樹, 神田 裕太郎, 辻本 龍, 宮崎 真吾, 張 鍾穎, 黒田 良祐, 西田 康太郎

  医学書院, Nov. 2018, 臨床整形外科, 53(11) (11), 975 - 980, Japanese


• プロ野球選手の下肢肉離れ 10年間の調査

  国分 毅, 美舩 泰, 乾 淳幸, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Nov. 2018, 日本臨床スポーツ医学会誌, 26(4) (4), S174 - S174, Japanese


• 70歳未満の広範囲腱板断裂に対する大腿筋膜補強による鏡視下修復術

  国分 毅, 美舩 泰, 乾 淳幸, 山裏 耕平, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Nov. 2018, 中部日本整形外科災害外科学会雑誌, 61(6) (6), 1215 - 1216, Japanese


• ラグビー選手のハムストリングス肉離れに対してノルディック・ハムストリングスを導入した予防効果の検討

  高橋 完靖, 星野 祐一, 荒木 大輔, 松本 彰生, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Nov. 2018, 日本臨床スポーツ医学会誌, 26(4) (4), S183 - S183, Japanese


• 10代患者における解剖学的二重束前十字靱帯再建術の術後成績

  中西 雄太, 松下 雄彦, 山本 哲也, 寛島 佑史, 山下 貴大, 宮地 伸晃, 茨木 一行, 田中 聡一, 荒木 大輔, 神崎 至幸, 星野 祐一, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Nov. 2018, 日本臨床スポーツ医学会誌, 26(4) (4), S257 - S257, Japanese


• 椎間板研究の最前線 椎間板変性と炎症

  高田 徹, 角谷 賢一朗, 由留部 崇, 張 鍾穎, 宮崎 真吾, 黒田 良祐, 西田 康太郎

  (株)医学書院, Nov. 2018, 臨床整形外科, 53(11) (11), 951 - 957, Japanese

  [Refereed]


• 前十字靱帯再建術後スポーツ復帰者の主観的評価に影響を及ぼす因子の検討

  柴田洋平, Matsushita Takehiko, 瀧口耕平, 上田雄也, 神崎至幸, 星野祐一, 酒井良忠, 黒田良祐

  (一社)日本臨床スポーツ医学会, Nov. 2018, 日本臨床スポーツ医学会誌, 26(4号) (4号), S255 - S255, Japanese

  Research society


• 前十字靱帯再建術後6ヵ月での客観的指標の目標値達成と術後1年時のスポーツ復帰およびその満足度との関連

  上田雄也, Matsushita Takehiko, 柴田洋平, 瀧口耕平, 神崎至幸, 星野祐一, 酒井良忠, 黒田良祐

  (一社)日本臨床スポーツ医学会, Nov. 2018, 日本臨床スポーツ医学会誌, 26(4号) (4号), S256 - S256, Japanese

  [Refereed]

  Research society


• 骨端線閉鎖前患者における二重束前十字靱帯再建術の術後成績

  Matsushita Takehiko, 寛島佑史, 中西雄太, 山本哲也, 山下貴大, 茨木一行, 田中聡一, 神崎至幸, 星野祐一, 黒田良祐

  (一社)日本臨床スポーツ医学会, Nov. 2018, 日本臨床スポーツ医学会誌, 26(4号) (4号), S257 - S257, Japanese

  Research society


• スポーツ選手・愛好家における自家培養軟骨移植術の術後臨床成績

  Matsushita Takehiko, 星野祐一, 神崎至幸, 田中聡一, 茨木一行, 宮地伸晃, 寛島佑史, 山下貴大, 中西雄太, 山本哲也, 黒田良祐

  (一社)日本臨床スポーツ医学会, Nov. 2018, 日本臨床スポーツ医学会誌, 26(4号) (4号), S168 - S168, Japanese

  Research society


• Treatment of Chronic Bony Mallet Fingers by Dorsal Extension Block Pinning with Percutaneous Curettage

  Takase F, Yamasaki K, Kokubu T, Mifune Yutaka, Inui A, Kuroda Ryosuke

  Dorsal extension block pinning is a commonly performed surgical technique for acute bony mallet fingers. However, the treatment of chronic bony mallet finger remains controversial. We investigated the use of dorsal extension block pinning with percutaneous curettage for chronic bony mallet fingers. Seven patients with chronic bony mallet fingers were treated by dorsal extension block pinning with percutaneous curettage. The average age was 17 (range, 12-23) years, and the average time from injury to surgery was 20 (range, 7-49) weeks. Bone union was achieved in all patients. None of the patients experienced pain after bone union. The average loss of distal interphalangeal joint extension was 6 (range, 5-20) degrees, and the average flexion was 59 (range, 40-80) degrees. The Crawford functional score was excellent in three patients, good in two, and fair in two. Dorsal extension block pinning with percutaneous curettage could be a useful treatment for chronic bony mallet fingers.

  Nov. 2018, Case Rep Orthop, 2018, 7297951 - 7297951, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Intraoperative soft tissue balance using novel medial preserving gap technique in posterior-stabilized total knee arthroplasty: comparison to measured resection technique

  Kanto Nagai, Hirotsugu Muratsu, Yutaro Kanda, Masanori Tsubosaka, Tomoyuki Kamenaga, Hidetoshi Miya, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Nov. 2018, Knee Surgery, Sports Traumatology, Arthroscopy, 26(11) (11), 3474 - 3481, English

  [Refereed]

  Scientific journal


• Computer-assisted surgery prevents complications during peri-acetabular osteotomy

  Hayashi Shinya, Hashimoto Shingo, Matsumoto Tomoyuki, Takayama Kouji, Shibanuma N, Ishida K, Nishida Kotaro, Kuroda Ryosuke

  PURPOSE: The aim of study is to evaluate the accuracy of a navigation system during curved peri-acetabular osteotomy (CPO). METHODS: Forty-seven patients (53 hips) with hip dysplasia were enrolled and underwent CPO with or without navigation during surgery. Clinical and radiographical evaluations were performed and compared between the navigation group and non-navigation group, post-operatively. RESULTS: The clinical outcomes were not significantly different between the navigation and non-navigation groups. Furthermore, post-operative reorientation of the acetabular fragment was similar between the navigation and non-navigation groups. However, the discrepancy between the pre-operative planning line and post-operative osteotomy line was significantly improved in the navigation group compared with that in the non-navigation group (p < 0.05). Further, the complication rate was significantly improved in the navigation group (p < 0.001). CONCLUSION: The accuracy of the osteotomy's position was significantly improved by using the navigation. Therefore, the use of navigation during peri-acetabular osteotomy can avoid complications.

  Nov. 2018, Int Orthop, 42(11) (11), 2555 - 2561, English, International magazine

  [Refereed]

  Scientific journal


• Changes in knee extensor strengths before and after medial patellofemoral ligament reconstruction

  Matsushita T, Araki D, Matsumoto Tomoyuki, Niikura Takahiro, Kuroda Ryosuke

  OBJECTIVE: Quadriceps dysfunction has been suggested as a complication after medial patellofemoral ligament (MPFL) reconstruction. The purpose of this study was to investigate changes in knee extensor strength before and after MPFL reconstruction. METHODS: Twenty patients who underwent MPFL reconstruction for unilateral recurrent patellar dislocation (18 females and 2 males; mean age 20.8 ± 7.6 years) were examined. The peak isometric torque at 60° and 90° of knee flexion and isokinetic knee extensor strength at speeds of 60°/s and 90°/s in operated and non-operated legs were measured using a dynamometer preoperatively and 6 months, 1 year, and 2 years postoperatively. The following parameters were evaluated: (1) body weight-adjusted muscle strength, (2) improvement index (post-/preoperative value × 100) (%), and (3) extensor strength ratio (operated/non-operated value × 100) (%). RESULTS: The mean knee extensor strength in both operated and non-operated legs significantly increased 2 years after surgery compared with that before surgery. At 2 years postoperatively, the improvement indexes of the isometric knee extensor strength at 60° and 90° and of the isokinetic knee extensor strength at 60°/s and 90°/s were 237%, 192%, 318%, and 186%, respectively, in the operated legs and 144%, 124%, 140%, and 140%, respectively, in the non-operated legs. At 2 years postoperatively, the mean isometric knee extensor strength ratios at 60° and 90° and the isokinetic knee extensor strength ratios at 60°/s and 180°/s were 81%, 84%, 81%, and 82%, respectively. CONCLUSIONS: Knee extensor strength was improved in most patients after MPFL reconstruction, at least compared with that before surgery, although an approximately 20% deficit against the non-operated legs remained even 2 years after surgery.

  Nov. 2018, Phys Sportsmed, 47(2) (2), 220 - 226, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Case Series of Comminuted Olecranon Fracture Treated by Plate Fixation; Do We Have to Remove the Plate

  Inui A, Kuroda T, Kurosawa T, Kokubu T, Mifune Yutaka, Nishimoto H, Kuroda Ryosuke

  Comminuted olecranon fracture requires surgical intervention. Plate fixation has been performed on the majority of cases. We reviewed the cases of comminuted olecranon fracture in young and middle age treated by plate osteosynthesis and analyzed the functional outcome, complications and ratio and timing of hardware removal. Fifteen cases of comminuted olecranon fractures treated by plate fixation were reviewed. Bone union was achieved in all cases, the average range of motion at the final follow up was -11° in extension, 133° in flexion, 89° in pronation and 88° in supination. Hardware removal performed in 12 cases in average 8.3 months postoperatively, in 2 cases elbow joint contracture release was performed during the hardware removal. In the co-payment (+) group, 4 cases (67%) removed the plate at average six months postoperatively. On the other hand, no co-payment group (workman's compensation insurance or automobile liability insurance) underwent hardware removal surgery in 8 cases (89%) at 9.6 months postoperatively. There was no statistical difference between the timing or prevalence of hardware removal between the groups. The present study showed high removal rate of hardware despite the excellent clinical result. The surgeons should be aware that plate fixation of the olecranon fracture requires the removal of a plate in the majority of cases.

  Nov. 2018, Kobe J Med Sci, 64(3) (3), E115 - E118, English, Domestic magazine

  [Refereed]

  Research institution

  Link to Kobe Univ. Repository (Kernel)


• A prospective randomized comparative study to determine appropriate edoxaban administration period, to prevent deep vein thromboembolism in patients with total knee arthroplasty

  Ishida K, Shibanuma N, Kodato K, Toda A, Sasaki H, Takayama Kouji, Hayashi Shinya, Hashimoto Shingo, Matsushita T, Niikura Takahiro, Kurosaka M, Kuroda Ryosuke, Matsumoto Tomoyuki

  BACKGROUND: This study aimed to determine the appropriate administration duration of edoxaban 15 mg (a factor Xa inhibitor) for the prevention of deep vein thrombosis (DVT) after total knee arthroplasty (TKA). METHODS: Our study comprised 202 patients who underwent TKA (excluding bilateral TKA) at our institution between 2014 and 2015. The subjects received edoxaban 15 mg daily for 1 (n = 93) or 2 (n = 109) weeks; group assignment was random. B-mode ultrasonography was performed 7 and 14 days post-TKA for the detection of DVT. We compared the incidence of DVT between the groups and examined for side effects. RESULTS: The demographic data of the patients in the 1- and 2-week administration groups were similar at baseline. DVT incidence did not differ significantly between the groups at 1 week post-TKA. However, it was significantly lower in the 2-week administration group (n = 0) than in the 1-week administration group (n = 7; p = 0.004) at 2 weeks post-DVT. Neither group exhibited symptomatic DVT. A total of six patients withdrew during the study period because of hepatic dysfunction. CONCLUSIONS: Our results show that the administration of edoxaban 15 mg is more effective in preventing DVT after TKA when administered for 2 weeks than for 1 week.

  Nov. 2018, J Orthop Sci, 23(6) (6), 1005 - 1010, English, Domestic magazine

  [Refereed]

  Scientific journal


• Total ankle arthroplasty with total talar prosthesis for talar osteonecrosis with ankle osteoarthritis: A case report.

  Nobuaki Chinzei, Noriyuki Kanzaki, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Yuichi Hoshino, Shingo Hashimoto, Koji Takayama, Daisuke Araki, Ryosuke Kuroda

  Oct. 2018, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• An evaluation of reaction time of dual task with eye tracker and leap motion

  Keisuke Takata, Kouki Nagamune, Ryosuke Kuroda

  Oct. 2018, Proc. of IEEE International Conference on Systems, Man, and Cybernetics, English

  [Refereed]


• 大学病院ICUにおける早期離床を目指した多職種連携介入の試み

  松本 健, 原田 理沙, 高宮 大輝, 三浦 靖史, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, Oct. 2018, The Japanese Journal of Rehabilitation Medicine, 55(秋季特別号) (秋季特別号), S292 - S292, Japanese


• 偽性副甲状腺機能低下症に対するリハビリテーション医療の経験

  原田 理沙, 高宮 大輝, 松本 健, 三浦 靖史, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, Oct. 2018, The Japanese Journal of Rehabilitation Medicine, 55(秋季特別号) (秋季特別号), S346 - S346, Japanese


• Successful First Gait of a Child With Hip-Disarticulation Prosthesis.

  Hitomi Hara, Teruya Kawamoto, Naomasa Fukase, Etsuko Katayama, Toshiyuki Takemori, Shuichi Fujiwara, Yoshitada Sakai, Kotaro Nishida, Ryosuke Kuroda, Toshihiro Akisue

  An infant boy underwent hip disarticulation for infantile fibrosarcoma immediately after birth. His rehabilitation began when he was 4 mos old and involved training with his left (residual) leg. He could stand with support at 12 mos. His initial prosthesis fitting was performed at the age of 13 mos. He could stand and walk with support at 15 mos of age and could walk with no additional support and go up and down stairs at 2 yrs. A single-axis prosthetic knee joint was introduced at the age of 2 yrs 3 mos. His first gait using a hip prosthesis was successful, and his prosthesis was replaced at appropriate intervals with no major problems. The authors believe that the key to achieving a successful prosthetic gait in children is good communication among the medical team, which should comprise an orthopedic doctor, rehabilitation doctor, nurse, physical therapist, prosthetist/orthotist, and the patient's parents.

  Oct. 2018, American journal of physical medicine & rehabilitation, 97(10) (10), e90-e92, English, International magazine

  [Refereed]

  Research society

  Link to Kobe Univ. Repository (Kernel)


• Transcutaneous carbon dioxide application suppresses bone destruction caused by breast cancer metastasis.

  Toshiyuki Takemori, Teruya Kawamoto, Takeshi Ueha, Mitsunori Toda, Masayuki Morishita, Etsuko Kamata, Naomasa Fukase, Hitomi Hara, Shuichi Fujiwara, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue

  Hypoxia plays a significant role in cancer progression, including metastatic bone tumors. We previously reported that transcutaneous carbon dioxide (CO2) application could decrease tumor progression through the improvement of intratumor hypoxia. Therefore, we hypothesized that decreased hypoxia using transcutaneous CO2 could suppress progressive bone destruction in cancer metastasis. In the present study, we examined the effects of transcutaneous CO2 application on metastatic bone destruction using an animal model. The human breast cancer cell line MDA-MB-231 was cultured in vitro under three different oxygen conditions, and the effect of altered oxygen conditions on the expression of osteoclast-differentiation and osteolytic factors was assessed. An in vivo bone metastatic model of human breast cancer was created by intramedullary implantation of MDA-MB-231 cells into the tibia of nude mice, and treatment with 100% CO2 or a control was performed twice weekly for two weeks. Bone volume of the treated tibia was evaluated by micro-computed tomography (µCT), and following treatment, histological evaluation was performed by hematoxylin and eosin staining and immunohistochemical staining for hypoxia-inducible factor (HIF)-1α, osteoclast-differentiation and osteolytic factors, and tartrate-resistant acid phosphatase (TRAP) staining for osteoclast activity. In vitro experiments revealed that the mRNA expression of RANKL, PTHrP and IL-8 was significantly increased under hypoxic conditions and was subsequently reduced by reoxygenation. In vivo results by µCT revealed that bone destruction was suppressed by transcutaneous CO2, and that the expression of osteoclast-differentiation and osteolytic factors, as well as HIF-1α, was decreased in CO2-treated tumor tissues. In addition, multinucleated TRAP-positive osteoclasts were significantly decreased in CO2-treated tumor tissues. Hypoxic conditions promoted bone destruction in breast cancer metastasis, and reversal of hypoxia by transcutaneous CO2 application significantly inhibited metastatic bone destruction along with decreased osteoclast activity. The findings in this study strongly indicated that transcutaneous CO2 application could be a novel therapeutic strategy for treating metastatic bone destruction.

  Oct. 2018, Oncology reports, 40(4) (4), 2079 - 2087, English, International magazine

  [Refereed]

  Scientific journal


• Intra-articular autologous uncultured adipose-derived stromal cell transplantation inhibited the progression of cartilage degeneration

  Kuroda Y, Matsumoto Tomoyuki, Hayashi Shinya, Hashimoto Shingo, Takayama Kouji, Kirizuki S, Tsubosaka M, Kamenaga T, Takashima Y, Matsushita T, Niikura Takahiro, Kuroda Ryosuke

  The role of uncultured adipose-derived stromal cells for osteoarthritis treatment remains unclear despite sporadic reports supporting their use in clinical settings. This study aimed to evaluate the therapeutic effects of autologous uncultured adipose-derived stromal cell transplantation in a rabbit osteoarthritis model. Uncultured adipose-derived stromal cells isolated from rabbits were administered via intra-articular injection into the knees after osteoarthritis onset. Animals were sacrificed at 8 and 12 weeks after osteoarthritis onset to compare the macroscopic, histological, and immunohistochemical characteristics between the uncultured adipose-derived stromal cell and control groups. Co-culture assay was also performed. The chondrocytes isolated from the model were co-cultured with adipose-derived stromal cells. The cell viability of chondrocytes and expression of chondrocyte-specific genes in the co-culture (uncultured adipose-derived stromal cell) group were compared with the mono-culture (control; chondrocytes only) group. In macroscopic and histological analyses, the uncultured adipose-derived stromal cell group showed less damage to the cartilage surface than the control group at 8 and 12 weeks after osteoarthritis onset. In immunohistochemical and co-culture assay, the uncultured adipose-derived stromal cell group showed higher expression of collagen type II and SRY box-9 and lower expression of matrix metalloproteinase-13 than the control group. The cell viability of chondrocytes in the uncultured adipose-derived stromal cell group was higher than that in the control group. Intra-articular autologous uncultured adipose-derived stromal cell transplantation inhibited the progression of cartilage degeneration in a rabbit osteoarthritis model by regulating chondrocyte viability and secreting chondrocyte-protecting cytokines or growth factors, which promote anabolic factors and inhibit catabolic factors. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1376-1386, 2019.

  Oct. 2018, J Orthop Res, 37(6) (6), 1376 - 1386, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Huge chronic expanding hematoma of the iliac bone following multiple hip surgeries: a case report.

  Masayuki Morishita, Hitomi Hara, Etsuko Katayama, Teruya Kawamoto, Naomasa Fukase, Toshiyuki Takemori, Shuichi Fujiwara, Kotaro Nishida, Ryosuke Kuroda, Toshihiro Akisue

  BACKGROUND: Chronic expanding hematoma is a rare entity resulting from trauma or surgery. This condition usually occurs in soft tissue, such as the trunk or extremities, while chronic expanding hematoma arising from bone has not been reported previously. We describe an unusual case of a huge intraosseous chronic expanding hematoma arising from the ilium, which had grown over a 40-year period following hip surgeries. CASE PRESENTATION: A 57-year-old Japanese woman presented with a 1.5-year history of right hip pain. She had a history of bilateral developmental dysplasia of the hip and had undergone bilateral arthroplasties in childhood. A physical examination revealed a large, firm, immobile mass at her right ilium. Based on radiographic findings, a type of slow-growing bone tumor was suspected, and an incisional biopsy was performed. A histopathologic examination revealed large amounts of old clotted blood within the lesion, and the capsule of the lesion was composed of dense, fibrous, connective tissue. There was no evidence of neoplasia, and chronic expanding hematoma was suspected. The lesion was resistant to conservative treatment, and so we performed an internal hemipelvectomy (including the capsule of the mass) and a reconstruction by hip transposition 2.5 years after the incisional biopsy. There was no recurrence of chronic expanding hematoma at the most recent follow-up of 1 year and 8 months postoperatively. CONCLUSIONS: A chronic expanding hematoma is characterized by its persistence and increasing size more than 1 month after the trauma or surgical event suspected of causing hemorrhage. To the best of our knowledge, this is the first report of chronic expanding hematoma arising from bone. We performed internal hemipelvectomy and hip transposition, and there has so far been no recurrence. This disease may be considered a differential diagnosis for bone tumor when the patient has a history of surgery or trauma, regardless of how many years have passed since the index event.

  Sep. 2018, Journal of medical case reports, 12(1) (1), 265 - 265, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 骨釘による指関節固定を行った化膿性DIP関節炎の2例

  中林 大治, 黒田 良祐, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史

  (一社)中部日本整形外科災害外科学会, Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 138 - 138, Japanese


• プロ野球投手におけるGlenohumeral internal rotation deficit(GIRD)の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 片岡 武史, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 198 - 198, Japanese


• ラット腱板修復モデルに対するゼラチンハイドロゲルシートを用いたbFGFとPRP同時投与の有効性

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 黒澤 堯, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 257 - 257, Japanese


• 骨粗鬆症患者におけるEQ-5D効用値と身体部位の疼痛スコアの関連

  乾 淳幸, 西本 華子, 美舩 泰, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2018, 日本骨粗鬆症学会雑誌, 4(Suppl.1) (Suppl.1), 280 - 280, Japanese


• 関節リウマチの生物製剤治療におけるSNPアルゴリズムの有用性

  亀長 智幸, 福田 康治, 林 申也, 酒井 良忠, 松原 司, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 134 - 134, Japanese

  [Refereed]


• 下肢偽関節手術後に低出力超音波パルスを使用した症例についての検討

  李相亮, Niikura Takahiro, 福井友章, Ooe Keisuke, 黒田良祐

  (一社)日本骨折治療学会, Sep. 2018, 骨折, 40(4号) (4号), 1107 - 1110, Japanese

  [Refereed]

  Scientific journal


• Comparison of Coronal Prosthetic Alignment After Total Knee Arthroplasty Using 3 Computer-Assisted Navigation Systems.

  Sasaki H, Ishida K, Shibanuma N, Takayama K, Hayashi S, Hashimoto S, Niikura T, Kurosaka M, Kuroda R, Matsumoto T

  Recent advances in surgical tools such as navigation systems have contributed to accurate implantation in total knee arthroplasty. Although several navigation systems have been developed, reports regarding which navigation system has better accuracy are few. Therefore, this study aimed to compare the accuracy of postoperative coronal alignment among 3 navigation systems. A total of 90 knee prostheses were implanted for 90 patients with osteoarthritis. Thirty patients were enrolled in each of the following 3 navigation groups: Stryker Navigation System II (computed tomography-free navigation; Stryker, Mahwah, New Jersey); OrthoPilot version 4.2 navigation system (computed tomography-free navigation; B. Braun Aesculap, Tuttlingen, Germany); and VectorVision navigation system (computed tomography-based navigation system; BrainLAB, Munich, Germany). Thirty consecutive total knee arthroplasties performed via the conventional method without navigation were selected as a control group for comparison with the navigation groups. Postoperative coronal mechanical axis and femoral and tibial coronal component angles were compared among the groups using long-leg standing radiographs for the rate of outliers beyond 3°. No differences were observed in the mean femoral and tibial component angles among the navigation and conventional groups. However, the proportion of outliers beyond 3° was higher in the conventional group than in the 3 navigation groups. No significant differences in the outlying values were found among the 3 navigation groups. These 3 navigation systems achieved equally accurate coronal mechanical alignment with fewer outliers. The navigation systems exhibited more precise implantation than the conventional method. [Orthopedics. 2018; 41(5):e621-e628.].

  Sep. 2018, Orthopedics, 41(5) (5), e621 - e628, English, International magazine

  [Refereed]

  Scientific journal


• The diagnostic reliability of the quantitative pivot-shift evaluation using an electromagnetic measurement system for anterior cruciate ligament deficiency was superior to those of the accelerometer and iPad image analysis.

  Toshikazu Tanaka, Yuichi Hoshino, Nobuaki Miyaji, Kazuyuki Ibaragi, Kyohei Nishida, Yuichiro Nishizawa, Daisuke Araki, Noriyuki Kanzaki, Takehiko Matsushita, Ryosuke Kuroda

  PURPOSE: Several non-invasive devices have been developed to obtain quantitative assessment of the pivot-shift test in clinical setting using similar but diverse measurement parameters. However, the clinical usability of those measurements has yet to be closely investigated and compared. The purpose of this study was to compare the diagnostic accuracy of three non-invasive measurement devices for the pivot-shift test. METHODS: Thirty patients with unilateral anterior cruciate ligament (ACL) injury were enrolled. The pivot-shift test was performed under general anaesthesia. Three devices, an accelerometer system (KiRA), an image analysis iPad application (iPad), and electromagnetic measurement system (EMS), were used simultaneously to provide two parameters, namely tibial acceleration monitored using KiRA and EMS, and tibial translation recorded using iPad and EMS. Side-to-side differences in each parameter and correlation between the measurements were tested, and a receiver-operating characteristic (ROC) curve analysis was conducted to compare their measurement accuracy. RESULTS: Significant side-to-side differences were successfully detected using any of the measurements (all p < 0.01). KiRA demonstrated moderate correlation with the EMS for tibial acceleration (r = 0.54; p < 0.01), while poor correlation was observed between iPad and the EMS for the translation (r = 0.28; p < 0.01). The ROC curve analysis demonstrated better accuracy for the detection of ACL insufficiency in the EMS than KiRA and iPad for tibial acceleration and translation, respectively. CONCLUSIONS: Although all three measurements were similarly capable of detecting ACL deficiency, the EMS has the advantage of comprehensive evaluation of the pivot-shift test by evaluating both tibial acceleration and translation with higher accuracy than those of KiRA and iPad. It could be suggested that any of those measurement tools might improve the clinical diagnosis of ACL insufficiency. LEVEL OF EVIDENCE: Diagnostic study of consecutive patients with a universally applied gold standard, Level Ib.

  Sep. 2018, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 26(9) (9), 2835 - 2840, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 大きく分離した巨大な有痛性外脛骨に伴う外反扁平足の1例

  平中良明, 神崎至幸, 山下貴大, 茨木一行, 松下雄彦, Kuroda Ryosuke

  Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(5号) (5号), 1079 - 1080, Japanese

  [Refereed]

  Scientific journal


• Downregulation of aquaporin 9 decreases catabolic factor expression through nuclear factor-κB signaling in chondrocytes

  Takeuchi K, Hayashi Shinya, Matumoto T, Hashimoto Shingo, Takayama Kouji, Chinzei N, Kihara S, Haneda M, Kirizuki S, Kuroda Y, Tsubosaka M, Nishida Kotaro, Kuroda Ryosuke

  Sep. 2018, Int J Mol Med, 42(3) (3), 1548 - 1558, English

  [Refereed]

  Scientific journal


• ATG5の抑制を介したオートファジーの阻害はストレス環境下でヒト椎間板細胞においてアポトーシスとセネッセンスを誘導し、生存率を低下させる

  伊藤雅明, Yurube Takashi, 垣内裕司, 武岡由樹, 神田裕太郎, Kakutani Kenichiro, 高田徹, Kuroda Ryosuke, Nishida Kotaro

  (一社)日本脊椎脊髄病学会, Sep. 2018, Journal of Spine Research, 9(9) (9), 1388 - 1393, Japanese

  [Refereed]

  Scientific journal


• 222nm紫外線照射の安全性と殺菌効果の検討

  福井 友章, 新倉 隆宏, 小田 崇弘, 隈部 洋平, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1757 - S1757, Japanese


• ラット腱板修復モデルにおけるゼラチンハイドロゲルシートを用いたbFGFとPRP同時投与の有効性の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 黒澤 尭, 山裏 耕平, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1907 - S1907, Japanese


• アポシニンは肩腱板由来細胞において終末糖化産物による酸化ストレスに対して抑制効果を示す

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 山裏 耕平, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1908 - S1908, Japanese


• 高血糖ストレスモデルを用いたラット腱細胞における老化制御因子NMN(nicotinamide mononucleotide)の抗炎症・酸化作用の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 尭, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S2037 - S2037, Japanese


• 関節リウマチ滑膜細胞におけるdecoy receptor 3によるcadherin 2発現誘導の検討

  福田 康治, 三浦 靖史, 林 申也, 前田 俊恒, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1985 - S1985, Japanese

  [Refereed]


• 新規低接着性scaffold collagen(LASCol)はラット骨欠損モデルにおいて骨癒合を促進する

  竹森俊幸, 深瀬直政, 森本康一, 國井沙織, 由留部崇, 武岡由樹, Kawamoto Teruya, 新倉隆宏, Hara Hitomi, 秋末敏宏, 黒田良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1999 - S1999, Japanese

  [Refereed]

  Research society


• iPS作製技術を用いた人工骨肉腫幹細胞株の樹立

  藤原周一, Kawamoto Teruya, 青井貴之, 小寺澤康文, Hara Hitomi, 深瀬直政, 蒲田悦子, 竹森俊幸, 秋末敏宏, 黒田良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1812 - S1812, Japanese

  [Refereed]

  Research society


• 問題解決に向けた膝前十字靱帯の基礎研究 ACL再建術後に残存する膝動的不安定性撲滅のためのpivot-shift testの定量的評価

  星野祐一, 神崎至幸, Matsushita Takehiko, 黒田良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8号) (8号), S1619 - S1619, Japanese

  [Invited]

  Research society


• 電磁気センサーを用いた足関節可動域の定量評価法の開発

  山下貴大, 星野祐一, 寛島佑史, 茨木一行, 宮地伸晃, 田中聡一, 西田京平, 神崎至幸, Matsushita Takehiko, 黒田良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8号) (8号), S1918 - S1918, Japanese

  [Refereed]

  Research society


• 足関節と足 慢性外側足関節不安定性に対する関節鏡下外側靱帯修復(Ankle and Foot Athroscopic lateral ligament repair for chronic lateral ankle instability)(英語)

  神崎至幸, 山本哲也, 山下貴大, 茨木一行, 星野祐一, Matsushita Takehiko, 黒田良祐

  (一社)日本整形外科スポーツ医学会, Aug. 2018, 日本整形外科スポーツ医学会雑誌, 38(4号) (4号), 515 - 515, Japanese

  Research society


• Rotator cuff tear healing process with graft augmentation of fascia lata in a rabbit model

  Kataoka T, Kokubu T, Muto T, Mifune Yutaka, Inui A, Sakata R, Nishimoto H, Harada Y, Takase F, Ueda Y, Kurosawa T, Yamaura K, Kuroda Ryosuke

  BACKGROUND: Fascia lata augmentation of massive rotator cuff tears has shown good clinical results. However, its biological effect during the early healing process is not clearly understood. The purpose of the study was to evaluate the biological efficacy of fascia lata augmentation during the early healing process of rotator cuff tears using a rabbit rotator cuff defect model. METHODS: The infraspinatus tendon was resected from the greater tuberosity of a rabbit to create a rotator cuff tear. The tendon edge was directly sutured to the humeral head. The rotator cuff repaired site was augmented with a fascia lata autograft (augmentation group, group A). The rotator cuff defect in the contralateral shoulder was repaired without augmentation (reattachment group, group R). A group with intact rotator cuff was set as the control group. Histological examinations and mechanical analysis were conducted 4 and 8 weeks postoperatively. RESULTS: In the HE staining, the tendon maturing score of group A was higher than that of group R at 4 weeks postoperatively. In the safranin O staining, proteoglycan staining at the repaired enthesis in group A at 4 weeks postoperatively was stronger than that in group R. Picrosirius red staining showed that type III and type I collagen in group A was more strongly expressed than that in group R at 4 weeks postoperatively. The ultimate failure load of the infraspinatus tendon-humeral head complex in group A was statistically higher than that in group R at 4 weeks postoperatively. The ultimate failure load of group A was similar to that of the control group. CONCLUSION: The biological and mechanical contribution of fascia lata augmentation for massive rotator cuff tears was analyzed in this study. Type III collagen was reported to be expressed during the tendon healing process. Although the biological action similar to natural ligament healing occurred around the fascia lata grafts, type III collagen was gradually replaced by type I collagen as the tissue matured. Our results suggest that fascia lata augmentation could stimulate biological healing and provide initial fixation strength of the repaired rotator cuff.

  Aug. 2018, J Orthop Surg Res, 13(1) (1), 200 - 200, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Minimally Invasive Treatment for Tibial Malrotation after Locked Intramedullary Nailing

  Takase K, Lee SY, Waki T, Fukui T, Ooe Keisuke, Matsumoto Tomoyuki, Matsushita Takehiko, Nishida Kotaro, Kuroda Ryosuke, Niikura Takahiro

  Rotational malreduction is a potential complication of intramedullary nailing for tibial shaft fractures. We experienced a symptomatic case of a 24° externally rotated malunion that we treated with minimally invasive corrective osteotomy. A 49-year-old man sustained a tibial shaft spiral fracture with a fibula fracture. He had been initially treated elsewhere with a reamed statically locked intramedullary nail. Bone union had been obtained, but he complained of asymmetry of his legs, difficulty walking and running, and the inability to ride a bicycle. We decided to perform corrective osteotomy in a minimally invasive fashion. After a 1 cm incision was made at the original fracture site, osteotomy for the affected tibia was performed with an osteotome after multiple efforts at drilling around the nail with the aim of retaining it. Fibula osteotomy was also performed at the same level. Two Kirschner wires that created an affected rotational angle between the fragments were inserted as a guide for correction. The distal locking screws were removed. Correct rotation was regained by matching the two wires in a straight line. Finally, the distal locking screws were inserted into new holes. The patient obtained bony union and has returned to his preinjury activities with no symptoms.

  Aug. 2018, Case Rep Orthop, 2018, 4190670 - 4190670, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Escherichia coli-derived BMP-2-absorbed β-TCP granules induce bone regeneration in rabbit critical-sized femoral segmental defects

  Kuroiwa Y, Niikura Takahiro, Lee SY, Ooe Keisuke, Iwakura T, Fukui T, Matsumoto Tomoyuki, Matsushita T, Nishida Kotaro, Kuroda Ryosuke

  PURPOSE: This study investigated whether Escherichia coli-derived bone morphogenetic protein (BMP)-2 (E-BMP-2) adsorbed onto β-tricalcium phosphate (β-TCP) granules can induce bone regeneration in critical-size femoral segmental defects in rabbits. METHODS: Bone defects 20 mm in size and stabilized with an external fixator were created in the femur of New Zealand white rabbits, which were divided into BMP-2 and control groups. E-BMP-2-loaded β-TCP granules were implanted into defects of the BMP-2 group, whereas defects in the controls were implanted with β-TCP granules alone. At 12 and 24 weeks after surgery, radiographs were obtained of the femurs and histological and biomechanical assessments of the defect area were performed. Bone regeneration was quantified using micro-computed tomography at 24 weeks. RESULTS: Radiographic and histologic analyses revealed bone regeneration in the BMP-2 group but not the control group; no fracturing of newly formed bone occurred when the external fixator was removed at 12 weeks. At 24 weeks, tissue mineral density, the ratio of bone volume to total volume, and volumetric bone mineral density of the callus were higher in the BMP-2 group than in control animals. In the former, ultimate stress, extrinsic stiffness, and failure energy measurements for the femurs were higher at 24 weeks than at 12 weeks. CONCLUSION: E-BMP-2-loaded β-TCP granules can effectively promote bone regeneration in long bone defects.

  Aug. 2018, Int Orthop, 43(5) (5), 1247 - 1253, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Correlation between quantitative pivot shift and generalized joint laxity: a prospective multicenter study of ACL ruptures.

  David Sundemo, Anna Blom, Yuichi Hoshino, Ryosuke Kuroda, Nicola Francesco Lopomo, Stefano Zaffagnini, Volker Musahl, James J Irrgang, Jón Karlsson, Kristian Samuelsson

  PURPOSE: To investigate whether an increased magnitude of quantitative rotatory knee laxity is associated with a greater level of generalized joint laxity in ACL-injured and contralateral knees. METHODS: A total of 103 patients were enrolled across four international centers to undergo anatomic ACL reconstruction. Rotatory knee laxity was evaluated preoperatively, both in the awake state and under anesthesia, using the standardized pivot shift test. Two devices were used to quantify rotatory knee laxity; an inertial sensor, measuring the joint acceleration, and an image analysis system, measuring the lateral compartment translation of the tibia. The presence of generalized joint laxity was determined using the Beighton Hypermobility Score. The correlation between the level of generalized joint laxity and the magnitude of rotatory knee laxity was calculated for both the involved knee and the non-involved knee. Further, patients were dichotomized into low (0-4) or high (5-9) Beighton Score groups. Alpha was set at < 0.05. RESULTS: Ninety-six patients had complete datasets, 83 and 13 in the low and high Beighton Score groups respectively. In anesthetized patients, there was a significant correlation between the degree of Beighton Score and quantitative pivot shift when analyzing the non-involved knee using the image analysis system (r = 0.235, p < 0.05). When analyzing the same knee, multivariate analysis adjusted for meniscal injury, age and gender revealed an increased odds ratio for patients with increased lateral compartment translation to be part of the high Beighton Score group (OR 1.86, 95% CI 1.10-3.17, p < 0.05). No other correlation was significant. When analyzing the dichotomized subgroups, no significant correlations could be established. CONCLUSION: The findings in this study suggest that there is a weak correlation between generalized joint laxity and the contralateral healthy knee, indicating increased rotatory knee laxity in these patients. Generalized joint laxity does not appear to correlate with rotatory knee laxity in ACL-injured knees. LEVEL OF EVIDENCE: Prospective cohort study; level of evidence, 2.

  Aug. 2018, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 26(8) (8), 2362 - 2370, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 筋膜リリース・Hydro-releaseを科学する 超音波エラストグラフィー法にて測定した、肩甲帯の疼痛に対する筋膜間ブロックの治療効果

  乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 黒澤 堯, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  日本整形外科超音波学会, Jul. 2018, 日本整形外科超音波学会学術集会プログラム・抄録集, 30回, 53 - 53, Japanese


• Shear Wave Elastographyを用いた投球動作による前腕屈筋群の組織弾性変化についての検討

  黒澤 尭, 乾 淳幸, 美舩 泰, 西本 華子, 片岡 武史, 山裏 耕平, 向原 伸太郎, 黒田 良祐

  日本整形外科超音波学会, Jul. 2018, 日本整形外科超音波学会学術集会プログラム・抄録集, 30回, 94 - 94, Japanese


• 全身画像検索が診断に有用であった慢性再発性多発性骨髄炎の2例

  西田 亮太, HARA HITOMI, KAWAMOTO TERUYA, 深瀬 直政, 川上 洋平, 秋末 敏宏, KURODA RYOSUKE

  (株)医学書院, Jul. 2018, 臨床整形外科, 53(7) (7), 643 - 648, Japanese

  [Refereed]

  Scientific journal


• Transcutaneous carbon dioxide enhances the antitumor effect of radiotherapy on oral squamous cell carcinoma.

  Eiji Iwata, Takumi Hasegawa, Takeshi Ueha, Daisuke Takeda, Izumi Saito, Teruya Kawamoto, Toshihiro Akisue, Yoshitada Sakai, Ryohei Sasaki, Ryosuke Kuroda, Takahide Komori

  Radiotherapy (RT) is one of the main treatment modalities for oral squamous cell carcinoma (OSCC), however, radioresistance is a major impediment to its clinical success and poses as a concern that needs to be addressed. Tumor hypoxia is known to be significantly associated with radioresistance in various malignancies, hence, resolving the hypoxic state of a tumor may improve the antitumor effect of RT on OSCC. We have previously revealed that transcutaneous CO2 induced mitochondrial apoptosis and suppressed tumor growth in OSCC by resolving hypoxia. Considering the previous study, we hypothesized that transcutaneous CO2 may enhance the antitumor effect of RT on OSCC by improving intratumoral hypoxia, thereby overcoming radioresistance. In the present study, the combination of transcutaneous CO2 and RT significantly inhibited tumor growth compared with other treatments. This combination therapy also led to decreased expression of HIF-1α in parallel with increased expression of the cleaved forms of caspase-3-8-9 and PARP, which play essential roles in mitochondrial apoptosis. Additionally, the combination therapy increased the expression of ROS modulator 1 and subsequent mitochondrial ROS production, compared to RT alone. These results indicated that transcutaneous CO2 could potentially improve the antitumor effect of RT by decreasing the intratumoral hypoxia and increasing the mitochondrial apoptosis. Our findings indicated that CO2 therapy may be a novel adjuvant therapy in combination with RT for OSCC.

  Jul. 2018, Oncology reports, 40(1) (1), 434 - 442, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Patients with a Dorr type C femoral bone require attention for using a Summit cementless stem: Results of total hip arthroplasty after a minimum follow-up period of 5 years after insertion of a Summit cementless stem

  Masanori Tsubosaka, Shinya Hayashi, Shingo Hashimoto, Koji Takayama, Ryosuke Kuroda, Tomoyuki Matsumoto

  Elsevier, Jul. 2018, Journal of Orthopaedic Science, 23(4) (4), 671 - 675, English

  [Refereed]

  Scientific journal


• High-grade rotatory knee laxity may be predictable in ACL injuries

  Volker Musahl, Jeremy Burnham, Jayson Lian, Adam Popchak, Eleonor Svantesson, Ryosuke Kuroda, Stefano Zaffagnini, Kristian Samuelsson, Andrew Sheean, Jeremy M. Burnham, Jayson Lian, Clair Smith, Adam Popchak, Elmar Herbst, Thomas Pfeiffer, Paulo Araujo, Alicia Oostdyk, Daniel Guenther, Bruno Ohashi, James J. Irrgang, Volker Musahl, Freddie H. Fu, Kouki Nagamune, Masahiro Kurosaka, Yuichi Hoshino, Ryosuke Kuroda, Alberto Grassi, Giulio Maria Marcheggiani Muccioli, Nicola Lopomo, Cecilia Signorelli, Federico Raggi, Stefano Zaffagnini, Eleonor Svantesson, Eric Hamrin Senorski, David Sundemo, Haukur Bjoernsson, Mattias Ahlden, Neel Desai, Kristian Samuelsson, Jon Karlsson, Pivot Study Group

  Springer Verlag, Jun. 2018, Knee Surgery, Sports Traumatology, Arthroscopy, 26(12) (12), 1 - 8, English

  [Refereed]

  Scientific journal


• Association of advanced glycation end products in Dupuytren disease

  Fumiaki Takase, Yutaka Mifune, Atsuyuki Inui, Yasuhiro Ueda, Takeshi Kataoka, Takeshi Kokubu, Ryosuke Kuroda

  BioMed Central Ltd., Jun. 2018, Journal of Orthopaedic Surgery and Research, 13(1) (1), 143, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A development of ankle joint range of motion measurement system using electromagnetic tracking device and force sensor

  Ryo Sakashita, Kouki Nagamune, Ryosuke Kuroda

  Jun. 2018, Proc. of World Automation Congress, English

  [Refereed]


• 四肢の腎癌骨転移に対して手術を施行した症例の検討

  Hara Hitomi, 秋末敏宏, Kawamoto Teruya, 深瀬直政, 竹森俊幸, 藤原周一, 黒田良祐

  (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6) (6), S1412 - S1412, Japanese


• 不安定性を有する転移性脊椎腫瘍に対する治療 脊椎転移に対する手術療法の効果

  角谷賢一朗, 酒井良忠, 由留部崇, 高田徹, Kawamoto Teruya, Hara Hitomi, 深瀬直政, 秋末敏宏, 西田康太郎, 黒田良祐

  (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6) (6), S1512 - S1512, Japanese

  [Refereed]

  Research society


• 粘液線維肉腫の治療成績

  Kawamoto Teruya, 藤田郁夫, 森下雅之, 秋末敏宏, Hara Hitomi, 深瀬直政, 蒲田悦子, 竹森俊幸, 藤原周一, 藤本卓也, 北山和道, 八尋俊輔, 黒田良祐

  (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6) (6), S1478 - S1478, Japanese

  [Refereed]

  Research society


• 経皮炭酸ガス吸収による低酸素環境の改善は乳癌骨転移モデルの骨破壊を抑制する

  竹森俊幸, Kawamoto Teruya, 上羽岳志, 戸田光紀, 蒲田悦子, 藤原周一, 深瀬直政, Hara Hitomi, 黒田良祐, 秋末敏宏

  (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6) (6), S1421 - S1421, Japanese

  [Refereed]

  Research society


• Low-grade fibromyxoid sarcoma(Evans tumor)の臨床病理学的検討 診断におけるFISHの有用性

  深瀬直政, 藤田郁夫, Kawamoto Teruya, 藤本卓也, 佐久間淑子, 廣瀬隆則, 神保直江, 伊藤智雄, Hara Hitomi, 秋末敏宏, 黒田良祐

  (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6) (6), S1385 - S1385, Japanese

  [Refereed]

  Research society


• The effects of high glucose condition on rat tenocytes in vitro and rat Achilles tendon in vivo

  Ueda Y, Inui A, Mifune Yutaka, Sakata R, Muto T, Harada Y, Takase F, Kataoka T, Kokubu T, Kuroda Ryosuke

  Jun. 2018, Bone Joint Res, 7(5) (5), 362 - 372, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 動脈塞栓術で治療可能であった外傷性腸骨筋血腫の1例

  鎮西 伸顕, 抽冬 晃司, 松本 知之, 橋本 慎吾, 高山 孝治, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 1 - 1, Japanese


• 色素性乾皮症A群の発達評価の検討

  酒井 良忠, 原田 理沙, 伊達 安理, 井上 美帆, 西本 華子, 黒田 良祐, 佐浦 隆一

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 3 - 8, Japanese


• 7p微小重複症候群に対するリハビリテーション医療介入の経験

  井上 美帆, 酒井 良忠, 伊達 安理, 原田 理沙, 西本 華子, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 3 - 4, Japanese


• 高齢者女性における下肢筋肉量と筋力・運動能力の比較

  西本 華子, 乾 淳幸, 美舩 泰, 植田 安洋, 片岡 武史, 黒澤 尭, 山裏 耕平, 酒井 良忠, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018, JOSKAS, 43(4) (4), 442 - 442, Japanese


• ラット腱板断裂モデルに対するb-FGFおよびPRP含侵ゼラチンハイドロゲルシート移植術の有効性の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 黒澤 堯, 山裏 耕平, 国分 毅, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018, JOSKAS, 43(4) (4), 492 - 492, Japanese


• プロ野球投手におけるGlenohumeral internal rotation deficit(GIRD)の検討

  山裏 耕平, 美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 尭, 国分 毅, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018, JOSKAS, 43(4) (4), 659 - 659, Japanese


• 福山型筋ジストロフィーの筋病変に対する超音波を用いた低侵襲評価

  原田 理沙, 池田 真理子, 西本 華子, 井上 美帆, 伊達 安理, 乾 淳幸, 三浦 靖史, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 1 - 2, Japanese


• 老化が腱炎に及ぼす影響の検討

  植田 安洋, 乾 淳幸, 美舩 泰, 片岡 武史, 黒澤 堯, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 1 - 2, Japanese


• Shear Wave Elastographyを用いた野球選手の肘内側側副靱帯の評価

  美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 2 - 1, Japanese


• 低TBS(Trabecular Bone Score)値の症例におけるBMD(Bone Mineral Density)の値による特徴

  西本 華子, 乾 淳幸, 美舩 泰, 井上 美帆, 植田 安洋, 片岡 武史, 原田 理沙, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 2 - 2, Japanese


• 筋膜間ブロックに対する、超音波エラストグラフィー法による治療評価

  乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 堯, 山裏 耕平, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 3 - 5, Japanese


• Cutting Edge on Clinical Management of Chronic Lateral Ankle Instability 足関節外側不安定症に対する鏡視下外側靱帯修復術

  神崎 至幸, 山下 貴大, 寛島 佑史, 茨木 一行, 宮地 伸晃, 田中 聡一, 西田 京平, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018, JOSKAS, 43(4) (4), 456 - 456, Japanese


• 関節リウマチ患者に対する音楽療法の有用性 PANASを用いた検討

  三浦 靖史, 福田 康治, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 2 - 7, Japanese

  [Refereed]


• 当院における骨転移リハビリテーションの現状と症例の検討

  伊達安理, 仲山舞, 小林慶通, 角谷賢一朗, 井上美帆, 原田理沙, 西本華子, 福田康治, Hara Hitomi, 秋末敏宏, 黒田良祐, 酒井良忠

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 3 - 10-7-2, Japanese

  [Refereed]

  Research society


• 新規低接着性コラーゲン(LASCol)はラット大腿骨骨欠損モデルにおいて骨癒合を促進する

  竹森俊幸, 深瀬直政, 森本康一, 國井沙織, 由留部崇, 武岡由樹, Hara Hitomi, Kawamoto Teruya, 黒田良祐, 秋末敏宏

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 1 - 6, Japanese

  [Refereed]

  Research society


• 経皮炭酸ガス吸収による低酸素環境の改善は乳癌骨転移モデルの骨破壊を抑制できる

  竹森俊幸, Kawamoto Teruya, 戸田光紀, 深瀬直政, Hara Hitomi, 黒田良祐, 秋末敏宏

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 1 - 5, Japanese

  [Refereed]

  Research society


• 大腿骨遠位内反骨切り術前後における膝蓋大腿関節の関節鏡視評価

  田中聡一, Matsushita Takehiko, 山下貴大, 寛島佑史, 宮地伸晃, 茨木一行, 西田京平, 星野祐一, 神崎至幸, 黒田良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018, JOSKAS, 43(4号) (4号), 290 - 290, Japanese

  Research society


• 足関節外側不安定症に伴う足根洞症候群に対する鏡視下外側靱帯修復術

  山下貴大, 神崎至幸, 寛島佑史, 宮地伸晃, 茨木一行, 田中聡一, 西田京平, 星野祐一, Matsushita Takehiko, 黒田良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018, JOSKAS, 43(4号) (4号), 715 - 715, Japanese

  Research society


• 前十字靱帯解剖学的二重束再建術におけるOutside-in法とTransportal法の骨孔評価 三次元コンピューター断層撮影を用いた解析

  宮地伸晃, Matsushita Takehiko, 神崎至幸, 星野祐一, 山下貴大, 寛島佑史, 茨木一行, 田中聡一, 西田京平, 黒田良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018, JOSKAS, 43(4号) (4号), 324 - 324, Japanese

  Research society


• 運動器とリハビリテーション医学 スポーツ 膝関節スポーツ損傷

  黒田良祐, 酒井良忠, Matsushita Takehiko

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), S339 - S339, Japanese

  Research society


• Os subfibulareを伴う足関節外側不安定症に対する鏡視下外側靱帯修復術の手術成績

  茨木一行, 神崎至幸, 山下貴大, 寛島佑史, 宮地伸晃, 田中聡一, 西田京平, 星野祐一, Matsushita Takehiko, 黒田良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018, JOSKAS, 43(4号) (4号), 715 - 715, Japanese

  Research society


• Cutting Edge on Clinical Management of Chronic Lateral Ankle Instability 足関節外側不安定症に対する鏡視下外側靱帯修復術

  神崎至幸, 山下貴大, 寛島佑史, 茨木一行, 宮地伸晃, 田中聡一, 西田京平, 星野祐一, Matsushita Takehiko, 黒田良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018, JOSKAS, 43(4号) (4号), 456 - 456, Japanese

  Research society


• ACL再建術後のPivot-shiftに対する前外側関節包合併損傷の影響の定量的評価による検討

  寛島佑史, 星野祐一, 山下貴大, 茨木一行, 宮地伸晃, 西田京平, 田中聡一, 神崎至幸, Matsushita Takehiko, 黒田良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018, JOSKAS, 43(4号) (4号), 327 - 327, Japanese

  Research society


• 前十字靱帯損傷膝に生じるpivot-shift現象に及ぼす半月板合併損傷の影響

  Hoshino Yuuichi, Matsushita Takehiko, 宮地伸晃, 西澤勇一郎, Kuroda Ryosuke

  (一社)日本整形外科スポーツ医学会, May 2018, 日本整形外科スポーツ医学会雑誌, 38(2号) (2号), 133 - 136, Japanese

  [Refereed]

  Scientific journal


• Navigated total Knee arthroplasty for osteoarthritis with extra-articular deformity

  Izumi Tani, Naoki Nakano, Koji Takayama, Kazunari Ishida, Ryosuke Kuroda, Tomoyuki Matsumoto

  Sociedade Brasileira de Ortopedia e Traumatologia, May 2018, Acta Ortopedica Brasileira, 26(3) (3), 170 - 174, English

  [Refereed]

  Scientific journal


• Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice

  Nishida K, Matsushita Takehiko, Takayama Kouji, Tanaka T, Miyaji N, Ibaraki K, Araki D, Kanzaki Noriyuki, Matsumoto Tomoyuki, Kuroda Ryosuke

  Objectives: This study aimed to examine the effects of SRT1720, a potent SIRT1 activator, on osteoarthritis (OA) progression using an experimental OA model. Methods: Osteoarthritis was surgically induced by destabilization of the medial meniscus in eight-week-old C57BL/6 male mice. SRT1720 was administered intraperitoneally twice a week after surgery. Osteoarthritis progression was evaluated histologically using the Osteoarthritis Research Society International (OARSI) score at four, eight, 12 and 16 weeks. The expression of SIRT1, matrix metalloproteinase 13 (MMP-13), a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5), cleaved caspase-3, PARP p85, and acetylated nuclear factor (NF)-κB p65 in cartilage was examined by immunohistochemistry. Synovitis was also evaluated histologically. Primary mouse epiphyseal chondrocytes were treated with SRT1720 in the presence or absence of interleukin 1 beta (IL-1β), and gene expression changes were examined by real-time polymerase chain reaction (PCR). Results: The OARSI score was significantly lower in mice treated with SRT1720 than in control mice at eight and 12 weeks associated with the decreased size of osteophytes at four and eight weeks. The delayed OA progression in the mice treated with SRT1720 was also associated with increased SIRT1-positive chondrocytes and decreased MMP-13-, ADAMTS-5-, cleaved caspase-3-, PARP p85-, and acetylated NF-κB p65-positive chondrocytes and decreased synovitis at four and eight weeks. SRT1720 treatment partially rescued the decreases in collagen type II alpha 1 (COL2A1) and aggrecan caused by IL-1β, while also reducing the induction of MMP-13 by IL-1β in vitro. Conclusion: The intraperitoneal injection of SRT1720 attenuated experimental OA progression in mice, indicating that SRT1720 could be a new therapeutic approach for OA.Cite this article: K. Nishida, T. Matsushita, K. Takayama, T. Tanaka, N. Miyaji, K. Ibaraki, D. Araki, N. Kanzaki, T. Matsumoto, R. Kuroda. Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice. Bone Joint Res 2018;7:252-262. DOI: 10.1302/2046-3758.73.BJR-2017-0227.R1.

  May 2018, Bone Joint Res, 7(3) (3), 252 - 262, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Medial joint line elevation of the tibia measured during surgery has a significant correlation with the limb alignment changes following medial unicompartmental knee arthroplasty

  Yuichi Kuroda, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Shingo Hashimoto, Masanori Tsubosaka, Takehiko Matsushita, Takahiro Niikura, Kotaro Nishida, Ryosuke Kuroda, Tomoyuki Matsumoto

  Springer Verlag, Apr. 2018, Knee Surgery, Sports Traumatology, Arthroscopy, 26(11) (11), 1 - 6, English

  [Refereed]

  Scientific journal


• 高血糖ストレスモデルを用いたラット腱細胞におけるアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 山裏 耕平, 黒田 良祐

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S161 - S161, Japanese


• マウスアキレス腱炎における老化の影響の検討

  植田 安洋, 乾 淳幸, 美舩 泰, 国分 毅, 黒田 良祐

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S162 - S162, Japanese


• ロープ状シリコン製スポンジを用いた腱縫合実習

  乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 堯, 山裏 耕平, 黒田 良祐

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S515 - S515, Japanese


• 橈骨遠位端骨折後変形治癒に対する骨移植を用いたOpen Wedge Osteotomyの術後成績

  美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 堯, 山裏 耕平, 黒田 司, 国分 毅, 黒田 良祐

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S565 - S565, Japanese


• エコー装置を用いた橈骨神経浅枝・尺骨神経背側枝の観察

  乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 堯, 山裏 耕平, 黒田 良祐

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S659 - S659, Japanese


• 母指CM関節障害に対するMini-TightRopeを用いたSuspensionplastyの治療成績

  山裏 耕平, 乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 堯, 国分 毅, 黒田 良祐

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S763 - S763, Japanese


• 橈骨遠位端骨折歴のある患者のバランス能力と筋量についての検討

  西本 華子, 乾 淳幸, 植田 安洋, 片岡 武史, 黒澤 堯, 山裏 耕平, 美舩 泰, 黒田 良祐

  (一社)日本手外科学会, Apr. 2018, 日本手外科学会雑誌, 35(1) (1), S786 - S786, Japanese


• Analysis of Graft Length Change Patterns in Medial Patellofemoral Ligament Reconstruction via a Fluoroscopic Guidance Method.

  Takehiko Matsushita, Daisuke Araki, Yuichi Hoshino, Shinya Oka, Kyohei Nishida, Toshikazu Tanaka, Nobuaki Miyaji, Noriyuki Kanzaki, Kazuyuki Ibaraki, Tomoyuki Matsumoto, Masahiro Kurosaka, Ryosuke Kuroda

  BACKGROUND: A fluoroscopic guidance method for medial patellofemoral ligament (MPFL) reconstruction has been widely used to determine the anatomic femoral attachment site. PURPOSE: To examine the graft length change patterns in MPFL reconstruction with a fluoroscopic guidance method. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: Forty-four knees of 42 patients who underwent MPFL reconstruction for the treatment of recurrent patellar dislocation were examined prospectively. During surgery, suture anchors were inserted into the proximal one-third and center of the patella. A guide pin for the femoral tunnel was inserted into the position reported by Schöttle et al based on the true lateral view of the knee under fluoroscopic control. Changes in graft length patterns of the proximal and center anchors were examined through 0° to 120° of knee flexion. Favorable changes in length patterns were defined as meeting 2 of 3 criteria: (1) not long during flexion (≤3 mm between 30° and 120° of flexion) and either (2) nearly isometric during flexion between 0° and 90° or (3) slightly long during maximum extension (≤3 mm). Other patterns were considered unfavorable. If the change in length pattern was unfavorable, then the pin for the femoral tunnel was moved to different positions until it was favorable. Knees were separated into the favorable group and the unfavorable group. Differences between the groups regarding radiographic parameters were assessed. Student t test or chi-square test was used for statistical analysis. RESULTS: Of the 44 knees, 31 (70.5%) showed favorable patterns. However, 13 knees (29.5%) showed unfavorable patterns; therefore, the position of the pin was changed. The mean ± SD distance from the original position to the final position was 5.3 ± 1.1 mm distal for 7 patients and 5.2 ± 0.4 mm posterodistal for 6 patients. Technical errors, including a nontrue lateral view and the tip of the wire not being in the determined area, were found for 4 of 13 knees in the unfavorable group. There was no statistical difference in radiographic parameters between the groups. CONCLUSION: The graft length change pattern could be nonphysiologic at the position determined through the fluoroscopic guidance method; thus, caution may be necessary. The change in length pattern should be checked before graft fixation. If the length change pattern is unfavorable, then it is advisable to move it approximately 5 to 7 mm distally or posterodistally from the first position.

  Apr. 2018, The American journal of sports medicine, 46(5) (5), 1150 - 1157, English, International magazine

  [Refereed]

  Scientific journal


• Stress distribution is deviated around the aperture of the femoral tunnel in the anatomic anterior cruciate ligament reconstruction

  Yuichi Hoshino, Ryosuke Kuroda, Yuichiro Nishizawa, Naoki Nakano, Kanto Nagai, Daisuke Araki, Shinya Oka, Shogo Kawaguchi, Kouki Nagamune, Masahiro Kurosaka

  Apr. 2018, Knee Surgery, Sports Traumatology, Arthroscopy, 26(4) (4), 1145 - 1151, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Depletion of aquaporin 1 decreased ADAMTS-4 expression in human chondrocytes

  Masahiko Haneda, Shinya Hayashi, Tomoyuki Matsumoto, Shingo Hashimoto, Koji Takayama, Nobuaki Chinzei, Shinsuke Kihara, Kazuhiro Takeuchi, Kotaro Nishida, Ryosuke Kuroda

  Spandidos Publications, Apr. 2018, Molecular Medicine Reports, 17(4) (4), 4874 - 4882, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 広範囲腱板断裂に対する大腿筋膜補強による鏡視下修復術

  国分 毅, 美舩 泰, 乾 淳幸, 山裏 耕平, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2018, 中部日本整形外科災害外科学会雑誌, 61(春季学会) (春季学会), 236 - 236, Japanese


• 母指CM関節症に対するMini-TightRopeを用いたThompson変法併用療法の治療成績

  山裏 耕平, 乾 淳幸, 美舩 泰, 西本 華子, 国分 毅, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2018, 中部日本整形外科災害外科学会雑誌, 61(春季学会) (春季学会), 261 - 261, Japanese


• 症候性豆状骨有鉤骨癒合症の1例

  乾 淳幸, 美舩 泰, 西本 華子, 山裏 耕平, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2018, 中部日本整形外科災害外科学会雑誌, 61(春季学会) (春季学会), 289 - 289, Japanese


• 手根管症候群手術症例における超音波検査を用いた母指球筋の質的評価

  名倉 一成, 金谷 貴子, 原田 義文, 鷲見 正敏, 乾 淳幸, 美舩 泰, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(2) (2), S164 - S164, Japanese


• 手関節背側部における皮神経のエコー画像解析

  乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 尭, 山裏 耕平, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(2) (2), S168 - S168, Japanese


• 腱板再断裂に対するアプローチ 腱板再断裂症例の検討 術前の危険因子について

  国分 毅, 美舩 泰, 乾 淳幸, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(2) (2), S355 - S355, Japanese


• 低TBS(trabecular bone score)値の症例におけるBMD(bone mineral density)の値による特徴 TBSとBMDが乖離する症例の検討

  西本 華子, 乾 淳幸, 美舩 泰, 植田 安洋, 片岡 武史, 黒澤 尭, 山裏 耕平, 楊 鴻生, 鷲見 正敏, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(3) (3), S840 - S840, Japanese


• 腰椎椎体骨折におけるtrabecular bone scoreとbone mineral densityの比較 TBSの骨折予測因子としての働き

  西本 華子, 乾 淳幸, 美舩 泰, 植田 安洋, 片岡 武史, 黒澤 尭, 山裏 耕平, 楊 鴻生, 鷲見 正敏, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(3) (3), S1096 - S1096, Japanese


• 外傷後の大腿骨内反変形を伴った変形性膝関節症に対して大腿骨遠位外反骨切り術を施行した1例

  寛島 佑史, 松下 雄彦, 荒木 大輔, 星野 祐一, 宮地 伸晃, 山下 貴大, 田中 聡一, 西田 京平, 黒田 良祐

  関西関節鏡・膝研究会, Mar. 2018, 関西関節鏡・膝研究会プログラム・演題抄録, 30回, 28 - 28, Japanese


• 膝関節再生の現状と展望

  松下 雄彦, 西田 京平, 田中 聡一, 宮地 伸晃, 山下 貴大, 寛島 佑司, 茨木 一行, 荒木 大輔, 神崎 至幸, 星野 祐一, 黒田 良祐

  関西関節鏡・膝研究会, Mar. 2018, 関西関節鏡・膝研究会プログラム・演題抄録, 30回, 43 - 43, Japanese


• 内側開大型高位脛骨骨切り術前後における膝蓋大腿関節の軟骨損傷の変化

  田中 聡一, 松下 雄彦, 岡 真也, 西田 京平, 荒木 大輔, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2018, 中部日本整形外科災害外科学会雑誌, 61(春季学会) (春季学会), 168 - 168, Japanese


• 前十字靱帯再建術-Update- 回旋不安定性の評価に基づくACL再建術の進歩

  星野 祐一, 荒木 大輔, 神崎 至幸, 松本 知之, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(2) (2), S445 - S445, Japanese


• RA患者においてデノスマブによる骨粗鬆症治療は患者QOLを改善する

  福田 康治, 林 申也, 寛島 佑史, 本田 久樹, 西本 華子, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2018, 中部日本整形外科災害外科学会雑誌, 61(春季学会) (春季学会), 331 - 331, Japanese

  [Refereed]


• リハビリテーション/臨床(外科)1 リウマチ患者に対する音楽療法 PANASを用いた検討

  三浦 靖史, 山崎 郁子, 雄鹿 賢哉, 福田 康治, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2018, 日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 431 - 431, Japanese

  [Refereed]


• 関節リウマチの病因・病態1 関節リウマチ滑膜細胞におけるCadherin 2の発現はDecoy receptor 3により誘導される

  福田 康治, 三浦 靖史, 前田 俊恒, 林 申也, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2018, 日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 477 - 477, Japanese

  [Refereed]


• 関節リウマチの病因・病態2 関節リウマチ患者における関節破壊進行の予測はSNPs解析で可能である 多施設コホート研究

  林 申也, 松原 司, 児矢野 聡, 舟橋 恵子, 福田 康治, 酒井 良忠, 黒田 良祐, 奥田 康介, 佐川 昭, 松野 博明, 泉原 智磨, 生野 英祐

  (一社)日本リウマチ学会, Mar. 2018, 日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 498 - 498, Japanese

  [Refereed]


• 関節リウマチの治療12:病理・病態・バイオマーカー 生物学的製剤治療中のRA患者における単純ヘルペスおよび帯状疱疹ヘルペス発症に関わる遺伝子多型性の検討

  福田 康治, 松原 司, 児矢野 聡, 舟橋 恵子, 奥田 康介, 林 申也, 酒井 良忠, 黒田 良祐, 佐川 昭, 松野 博明, 泉原 智麿, 生野 英祐

  (一社)日本リウマチ学会, Mar. 2018, 日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 569 - 569, Japanese

  [Refereed]


• 生物学的製剤の治療継続率の比較 追跡期間10年を超える症例を対象とする

  福田 康治, 松原 司, 舟橋 恵子, 児矢野 聡, 伊丹 哲, 奥田 康介, 林 申也, 酒井 良忠, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2018, 日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 790 - 790, Japanese

  [Refereed]


• Low-grade fibromyxoid sarcoma(Evans tumor)の臨床病理学的検討 診断におけるFUS break-apart FISHの有用性

  深瀬直政, 藤田郁夫, Kawamoto Teruya, 藤本卓也, 佐久間淑子, 廣瀬隆則, 神保直江, 伊藤智雄, Hara Hitomi, 秋末敏宏, 黒田良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(3) (3), S912 - S912, Japanese


• 脊椎転移に対する集学的治療は予後を延長させる

  角谷賢一朗, 酒井良忠, 由留部崇, 高田徹, 伊藤雅明, 垣内裕司, 武岡由樹, 神田祐太郎, 秋末敏宏, Kawamoto Teruya, Hara Hitomi, 黒田良祐, 西田康太郎

  (一社)日本脊椎脊髄病学会, Mar. 2018, Journal of Spine Research, 9(3) (3), 429 - 429, Japanese

  [Refereed]

  Research society


• 悪性軟部腫瘍肺転移症例における予後因子

  Kawamoto Teruya, 藤田郁夫, 秋末敏宏, Hara Hitomi, 深瀬直政, 蒲田悦子, 竹森俊幸, 藤原周一, 藤本卓也, 森下雅之, 黒田良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(3) (3), S1248 - S1248, Japanese

  [Refereed]

  Research society


• 膝前十字靱帯損傷の治療

  黒田良祐, Matsushita Takehiko, 星野祐一

  Mar. 2018, 日本整形外科学会雑誌, 92(3号) (3号), S1092, Japanese

  Research society


• 半月板温存を目指した治療 半月水平断裂に対する治療戦略

  Matsushita Takehiko, 荒木大輔, 星野祐一, 寛島佑史, 宮地伸晃, 山下貴大, 茨木一行, 神崎至幸, 黒田良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(2号) (2号), S433 - S433, Japanese

  [Invited]

  Research society


• 当科における人工足関節置換術(TAA)での、術後骨溶解(osteolysis)のZone分類と評価

  山下貴大, 神崎至幸, 寛島佑史, 茨木一行, 宮地伸晃, 田中聡一, 西田京平, 星野祐一, Matsushita Takehiko, 黒田良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(3号) (3号), S672 - S672, Japanese

  [Refereed]

  Research society


• 当科における人工距骨併用人工足関節置換術(combined TAA)の治療成績と適応の検討

  神崎至幸, 山下貴大, 寛島佑史, 茨木一行, 宮地伸晃, 田中聡一, 西田京平, 星野祐一, Matsushita Takehiko, 黒田良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(3号) (3号), S670 - S670, Japanese

  Research society


• 足部・足関節疾患および外傷に対する保存療法-Evidence based conservative treatment- アキレス腱断裂に対する保存療法

  神崎至幸, 山下貴大, 寛島佑史, 茨木一行, 宮地伸晃, 田中聡一, 西田京平, 荒木大輔, 星野祐一, Matsushita Takehiko, 黒田良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(2号) (2号), S387 - S387, Japanese

  [Refereed]

  Scientific journal


• 人工足関節置換術後における距骨下関節代償機能のX線学的検討

  茨木一行, 神崎至幸, 山下貴大, 寛島佑史, 宮地伸晃, 田中聡一, 西田京平, 星野祐一, Matsushita Takehiko, 黒田良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(3号) (3号), S672 - S672, Japanese

  Research society


• 前十字靱帯再建術後に復帰したスポーツに対する満足度と関連する要因の検討

  上田 雄也, MATSUSHITA TAKEHIKO, 柴田 洋平, 瀧口 耕平, 木田 晃弘, ONO REI, ARAKI DAISUKE, KANZAKI NORIYUKI, HOSHINO YUICHI, 丸山 孝樹, 酒井 良忠, KURODA RYOSUKE

  国立大学リハビリテーション療法士協議会, Mar. 2018, 国立大学リハビリテーション療法士学術大会誌, 39回, 76 - 81, Japanese

  [Refereed]

  Scientific journal


• The Influence of Ruptured Scar Pattern on the Healing Potential of Anterior Cruciate Ligament Remnant Cells

  KirizukiS, Matsumoto Tomoyuki, UehaT, UefujiA, InokuchiT, TakayamaK, Hashimoto Shingo, HayashiS, MatsushitaT, Kuroda Ryosuke

  BACKGROUND: Vascular CD34+ cells in anterior cruciate ligament (ACL) tissues have a potential for high proliferation and multilineage differentiation, which can accelerate tendon-bone healing after ACL reconstruction. To predict outcomes of ACL reconstruction with remnant preservation or ruptured tissue incorporation, patient characteristics should be considered. However, the influence of ACL remnant morphologic pattern on healing potential remains unknown. HYPOTHESIS: The healing potential of ACL remnants could differ among their morphologic patterns. STUDY DESIGN: Descriptive laboratory study. METHODS: ACL remnant tissues were harvested from patients aged <35 years who received primary ACL reconstruction within 3 months after injury. The tissues were evaluated according to the Crain classification (4 patterns). The patterns were divided into 2 groups: the reattachment group (Crain I-III) and the nonreattachment group (Crain IV). ACL remnant cells were characterized via fluorescence-activated cell sorting. The potential for proliferation and multilineage differentiation was assessed and compared between the groups. RESULTS: The ratio of CD34+ cells was significantly higher in the nonreattachment group than in the reattachment group. In early passages, the nonreattachment group had a significantly higher expansion potential than the reattachment group. In the evaluation of osteogenic and endothelial differentiation potential, the nonreattachment group showed a higher potential in immunohistochemical/histochemical staining and quantitative real-time polymerase chain reaction analysis as compared with the reattachment group. CONCLUSION: In the subacute phase, ACL remnant tissue of the nonreattachment group possibly has a higher healing potential than that of the reattachment group. CLINICAL RELEVANCE: If healing potential differs among the morphologic patterns of ACL remnants, surgeons may expect the healing potential when preserving remnants.

  Mar. 2018, Am J Sports Med, 46(6) (6), 1382 - 1388, English, International magazine

  [Refereed]

  Scientific journal


• Decoy receptor 3 down-regulates centrosomal protein 70 kDa specifically in rheumatoid synovial fibroblasts.

  Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Ryosuke Kuroda

  OBJECTIVES: Decoy receptor 3 (DcR3) competitively binds to Fas ligand, lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells (LIGHT) and TNF-like ligand 1A (TL1A), thereby preventing their effects. Using a microarray assay, we previously newly identified centrosomal protein 70 kDa (CEP70) as one of the genes whose expression in fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA-FLS) is reduced by DcR3. Here, we investigated the significance of DcR3 regulation of CEP70 for RA-FLS. METHODS: Synovial samples were obtained from RA patients who had never been treated with biologics and from osteoarthritis (OA) patients. CEP70 mRNA expression was quantified using RT-qPCR analysis. CEP70 protein expression was assessed using immunohistochemical and western blot analyses. RESULTS: CEP70 was expressed predominantly in the superficial lining layer in RA synovial tissue. CEP70 expression was dose-dependently downregulated by DcR3-Fc in RA-FLS but was not downregulated in OA-FLS. TL1A antibody prevented the DcR3-Fc inhibitory effects on CEP70 expression in RA-FLS. CONCLUSIONS: These results indicated that DcR3 reduces CEP70 expression in RA-FLS by binding to membrane-bound TL1A and may suppress RA-FLS proliferation. The reduction in CEP70 expression by DcR3/TL1A signaling may control the hyperplasia of RA synovium.

  Mar. 2018, Modern rheumatology, 28(2) (2), 287 - 292, English, International magazine

  [Refereed]

  Scientific journal


• Comparison of Intraoperative Soft Tissue Balance Between Cruciate-Retaining and Posterior-Stabilized Total Knee Arthroplasty Performed by a Newly Developed Medial Preserving Gap Technique

  TsubosakaM, MuratsuH, MiyaH, Kuroda Ryosuke, Matsumoto Tomoyuki

  BACKGROUND: Medial stability of the knee is considered to be associated with good clinical results after total knee arthroplasty (TKA). This study aimed to compare intraoperative soft tissue balance between cruciate-retaining (CR) and posterior-stabilized (PS) TKA performed by a newly developed medial preserving gap technique, which aimed at preserving medial stability throughout the range of motion. METHODS: Seventy CR-TKAs and 70 PS-TKAs were performed in patients with varus type osteoarthritis with the novel technique guided by tensor measurements. Final intraoperative soft tissue balance with femoral trial component in place and patellofemoral joint reduced, including the joint component gap and varus/valgus ligament balance (varus angle), with the knee at 0° (full extension), 10° (extension), 30°, 45°, 60°, 90° (flexion), 120°, and 135° (deep flexion), was measured with Offset Repo-Tensor under 40 lbs of joint distraction force. The medial compartment gap (MCG), lateral compartment gap, and medial joint looseness (MCG-polyethylene insert thickness) at each flexion angle were calculated from the measured joint component gap and varus ligament balance, and compared between CR-TKA and PS-TKA. RESULTS: The MCGs from extension to deep flexion of the knee showed no significant differences between CR-TKA and PS-TKA. The lateral compartment gaps in PS-TKA from 30° to 60° of knee flexion was significantly larger than those in CR-TKA (P < .05). Medial joint looseness showed no significant differences between CR-TKA and PS-TKA which is consistent within 1 mm from extension to flexion of the knee. CONCLUSION: PS-TKA similarly achieved medial stability comparable to CR-TKA using the medial preserving gap technique.

  Mar. 2018, J Arthroplasty, 33(3) (3), 729 - 734, English, International magazine

  [Refereed]

  Scientific journal


• Altered expression of microRNA during fracture healing in diabetic rats

  S. Takahara, S. Y. Lee, T. Iwakura, K. Oe, T. Fukui, E. Okumachi, T. Waki, M. Arakura, Y. Sakai, K. Nishida, R. Kuroda, T. Niikura

  British Editorial Society of Bone and Joint Surgery, Feb. 2018, Bone and Joint Research, 7(2) (2), 139 - 147, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Quadriceps strength recovery after ACL reconstruction using hamstrings tendon autograft and return to play

  Yuichi Hoshino, Ryosuke Kuroda

  Springer-Verlag Berlin Heidelberg, Jan. 2018, Return to Play in Football: An Evidence-based Approach, 237 - 244, English

  In book


• 投球動作における肘関節周囲筋群の組織弾性はどのように変化するか?

  黒澤 尭, 美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 山裏 耕平, 国分 毅, 黒田 良祐

  日本肘関節学会, Jan. 2018, 日本肘関節学会雑誌, 25(1) (1), S121 - S121, Japanese


• 小児経肘頭脱臼骨折の1例

  山裏 耕平, 乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 堯, 国分 毅, 黒田 良祐

  日本肘関節学会, Jan. 2018, 日本肘関節学会雑誌, 25(1) (1), S145 - S145, Japanese


• Revision ACL再建術の臨床成績

  荒木 大輔, 松下 雄彦, 星野 祐一, 神崎 至幸, 木田 晃弘, 瀧口 耕平, 柴田 洋平, 上田 雄也, 黒田 良祐

  スポーツ傷害フォーラム, Jan. 2018, スポーツ傷害, 23, 5 - 5, Japanese


• アキレス腱付着部症に対してsuture bridge法にPercutaneous Achilles Repair System(PARS)を併用して加療した2例

  茨木 一行, 神崎 至幸, 山下 貴大, 寛島 佑史, 宮地 伸晃, 田中 聡一, 西田 京平, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  スポーツ傷害フォーラム, Jan. 2018, スポーツ傷害, 23, 10 - 10, Japanese


• 座談会 わが国における再生医療臨床研究の現状と課題 : 臨床研究をスムーズに進めるための学会の果たすべき役割

  岡田 潔, 黒田 良祐, 佐藤 陽治, 田畑 泰彦, 森尾 友宏, 畠 賢一郎

  メディカルレビュー社, Jan. 2018, 再生医療 : 日本再生医療学会雑誌, 17(2) (2), 139 - 147, Japanese

  Scientific journal


• Rescue of ankylosing hip following open reduction and internal fixation of acetabular fracture by surgical resection of heterotopic ossification: A case report

  Kitayama K, Kawakami Y, Fukui T, Ooe Keisuke, Kuroda Ryosuke, Niikura Takahiro

  INTRODUCTION: Heterotopic ossification is a major complication after surgical treatment of acetabular fractures. Heterotopic ossification generally involves the large joints, often limits the range of motion, and may cause ankylosis. PRESENTATION OF CASE: This case report describes a 59-year-old man with severe heterotopic ossification who developed an acetabular fracture and resultant hip ankylosis, which was rescued by surgical resection of the heterotopic ossification. He had accompanying head injury and multiple other fractures, which were treated conservatively. Open reduction with internal fixation of the acetabular fracture was performed through the ilioinguinal and Kocher-Langenbeck combined approach. The patient unexpectedly returned to our hospital 7.5 months after the fracture surgery. We found that his left hip joint was completely ankylosed by severe heterotopic ossification. We performed surgical resection of the heterotopic ossification through a direct lateral approach 9.5 months after the initial surgery. At the final follow-up, 5.5 years after the heterotopic ossification resection surgery, the hip function including the range of motion was satisfactory. Radiographs showed no signs of recurrence, and he could walk with no support. DISCUSSION: The only effective treatment for established HO is surgical excision. Whether delayed or early surgical resection of heterotopic ossification is more effective remains controversial. CONCLUSION: We considered that waiting for a long time before surgical resection of the heterotopic ossification would lead to more disability, and early resection of the heterotopic ossification was not a contraindication despite the fact that the uptake on the bone scan was still intense.

  2018, Int J Surg Case Rep, 53, 107 - 111, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Locking plate osteosynthesis for a femoral fracture and subsequent nonunion in a patient with osteopetrosis

  Matsuo T, Lee SY, Iwakura T, Fukui T, Ooe Keisuke, Matsumoto Tomoyuki, Matsushita Takehiko, Nishida Kotaro, Kuroda Ryosuke, Niikura Takahiro

  INTRODUCTION: Osteopetrosis is a skeletal disorder characterized by increased osteodensity and a remodeling defect. The fragility of dense sclerotic bones may lead to an increased incidence of fractures. Although internal fixation can be performed, technical challenges may be experienced because of the increased bone density. Complications such as delayed union, nonunion, or implant failure may occur postoperatively. PRESENTATION OF CASE: We describe a patient with autosomal-dominant osteopetrosis type 2 who suffered a shaft fracture below a plate of his right femur. We performed osteosynthesis with a single locking plate. Union was delayed, and plate breakage occurred along with nonunion of the fracture. The nonunion was addressed using double locking plates, which secured fixation and allowed complete fracture healing. DISCUSSION: There were three reasons of nonunion in our case. First, we left gaps between the fragments. Second, we used mainly cerclage wires, rather than screws, for plate fixation, which led to inadequate stability. Third, the patient was large (height 167 cm, weight 93.1 kg), so the single plate provided insufficient fixing force. We then used double locking plates and attained stronger internal fixation with complete fracture healing. CONCLUSION: Double plating with locking plates may be an effective treatment option for femoral fractures in patients with osteopetrosis.

  2018, Int J Surg Case Rep, 51, 395 - 399, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Prothrombin time-international normalized ratio is a useful marker for edoxaban efficacy in preventing venous thromboembolism after total knee arthroplasty

  Kazuki Kodato, Kazunari Ishida, Nao Shibanuma, Akihiko Toda, Koji Takayama, Shinya Oka, Shinya Hayashi, Shingo Hashimoto, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  Springer-Verlag France, Jan. 2018, European Journal of Orthopaedic Surgery and Traumatology, 28(1) (1), 103 - 108, English

  [Refereed]

  Scientific journal


• The Influence of Postoperative Knee Stability on Patient Satisfaction in Cruciate-Retaining Total Knee Arthroplasty

  Tomoyuki Kamenaga, Hirotsugu Muratsu, Yutaro Kanda, Hidetoshi Miya, Ryosuke Kuroda, Tomoyuki Matsumoto

  Churchill Livingstone Inc., 2018, Journal of Arthroplasty, 33(8) (8), 2475 - 2479, English

  [Refereed]

  Scientific journal


• Posterior Reference Position Affects Intraoperative Kinematic and Soft Tissue Balance in Navigated Posterior-Stabilized Total Knee Arthroplasty

  Kazunari Ishida, Nao Shibanuma, Koji Takayama, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  Churchill Livingstone Inc., 2018, Journal of Arthroplasty, 33(9) (9), 2851 - 2857, English

  [Refereed]

  Scientific journal


• プロ野球投手に発症した筋皮神経単独損傷の1例

  山裏 耕平, 国分 毅, 乾 淳幸, 美舩 泰, 黒田 良祐

  日本末梢神経学会, Dec. 2017, 末梢神経, 28(2) (2), 319 - 319, Japanese


• Consecutive Bilateral Hip Arthroscopy for Symptomatic Bilateral Femoroacetabular Impingement in an Elite Rugby player: A Case Report

  Nobuaki Chinzei, Shingo Hashimoto, Shinya Hayashi, Noriyuki Kanzaki, Daisuke Araki, Ryosuke Kuroda, Masahiro Kurosaka

  Dec. 2017, JOURNAL OF NIPPON MEDICAL SCHOOL, 84(6) (6), 280 - 285, English

  [Refereed]

  Scientific journal


• Triweekly administration of parathyroid hormone (1-34) accelerates bone healing in a rat refractory fracture model

  Yohei Kumabe, Sang Yang Lee, Takahiro Waki, Takashi Iwakura, Shunsuke Takahara, Michio Arakura, Yu Kuroiwa, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda, Takahiro Niikura

  Dec. 2017, BMC MUSCULOSKELETAL DISORDERS, 18(1) (1), 545, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction

  M. Ito, T. Yurube, K. Kakutani, K. Maeno, T. Takada, Y. Terashima, Y. Kakiuchi, Y. Takeoka, S. Miyazaki, R. Kuroda, K. Nishida

  Dec. 2017, OSTEOARTHRITIS AND CARTILAGE, 25(12) (12), 2134 - 2146, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Post-cam clunk syndrome after posterior stabilized total knee arthroplasty as a sign of early femoral component loosening

  TodaA, TeiK, Matsumoto Tomoyuki, IshidaK, SasakiH, KodatoK, NishizawaY, KirizukiS, ShibanumaN, TateishiH, Kuroda Ryosuke, KurosakaM

  Soft tissue impingements are well-known complications of total knee arthroplasty. The impingements usually occur between the medial or lateral femoral component and tibial insert, and between the patella and femoral components. We report a rare case of impingement of the soft tissue between the femoral intercondylar fossa and post of the polyethylene insert, which caused pain and walking disability. After the surgery for the arthroscopic removal of the soft tissue, the symptoms disappeared. However, prosthetic loosening of the femur occurred several months after the arthroscopic surgery, requiring revision surgery. We would propose to call this symptom as post-cam clunk syndrome.

  Dec. 2017, Asia Pac J Sports Med Arthrosc Rehabil Technol, 11, 19 - 21, English, International magazine

  [Refereed]

  Scientific journal


• Anthology Hip SystemのDEXAによる術後2年の骨密度変化の検討

  竹内一裕, 橋本慎吾, 松本知之, Hayashi Shinya, 高山孝治, 木原伸介, 井口高雄, 桐月伸輔, 羽田勝彦, 黒田雄一, Kuroda Ryosuke

  Dec. 2017, 日本人工関節学会誌, 47, 643 - 644, Japanese

  [Refereed]

  Research society


• Comparison of passenger unit movements between stair and level walkings using inertial sensors

  Yuki Azuma, Kouki Nagamune, Ryosuke Kuroda

  Institute of Electrical and Electronics Engineers Inc., Nov. 2017, 2017 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2017, 2017-, 3062 - 3066, English

  [Refereed]

  International conference proceedings


• 非結核性抗酸菌性DIP関節炎に対して骨釘による一期的関節固定を行った1例

  楠瀬 正哉, 美舩 泰, 乾 淳幸, 植田 安洋, 片岡 武史, 黒沢 尭, 山裏 耕平, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Nov. 2017, 中部日本整形外科災害外科学会雑誌, 60(6) (6), 1095 - 1095, Japanese


• Arthroscopic Debridement of a Talar Cyst and Bone Grafting with the Osteochondral Autograft Transfer System A Case Report

  Nobuaki Chinzei, Noriyuki Kanzaki, Takaaki Fujishiro, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka

  Nov. 2017, JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION, 107(6) (6), 541 - 547, English

  [Refereed]

  Scientific journal


• Remaining mild varus limb alignment leads to better clinical outcome in total knee arthroplasty for varus osteoarthritis

  Kyohei Nishida, Tomoyuki Matsumoto, Koji Takayama, Kazunari Ishida, Naoki Nakano, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Springer Verlag, Nov. 2017, Knee Surgery, Sports Traumatology, Arthroscopy, 25(11) (11), 3488 - 3494, English

  [Refereed]

  Scientific journal


• がん患者の脊椎転移に対する直視下手術と経皮的後方固定術の全身状態、ADL、QOL改善効果

  角谷賢一朗, 前野耕一郎, 高田徹, Kuroda Ryosuke, 西田康太郎

  (一社)中部日本整形外科災害外科学会, Nov. 2017, 中部日本整形外科災害外科学会雑誌, 60(6) (6), 1079 - 1080, Japanese

  [Refereed]

  Scientific journal


• Transcutaneous carbon dioxide application with hydrogel prevents muscle atrophy in a rat sciatic nerve crush model

  NishimotoH, InuiA, UehaT, InoueM, AkahaneS, HaradaR, Mifune Yutaka, KokubuT, NishidaK, Kuroda Ryosuke, Sakai Yoshitada

  The acceleration of nerve regeneration remains a clinical challenge. We previously demonstrated that transcutaneous CO2 application using a novel hydrogel increases the oxygen concentration in local tissue via an "artificial Bohr effect" with the potential to prevent muscle atrophy. In this study, we investigated the effect of transcutaneous CO2 administration on limb function after peripheral nerve injury in a rat sciatic nerve injury model. In total, 73 Sprague-Dawley rats were divided into a sham group, a control group (crush injury to sciatic nerve and no treatment) or a CO2 group (crush injury with transcutaneous CO2 application). CO2 was administered percutaneously for 20 min five times per week. Scores for the sciatic function index and pinprick test were significantly higher in the CO2 group than control group. The muscle wet weight ratios of the tibialis anterior and soleus muscles were higher in the CO2 group than control group. Electrophysiological examination showed that the CO2 group had higher compound motor action potential amplitudes and shorter distal motor latency than the control group. Histological examination of the soleus muscle sections at postoperative week 2 showed shorter fiber diameter in the control group than in the CO2 group. The mRNA expression of Atrogin-1 and MuRF-1 was lower, mRNA expression of VEGF and myogenin and MyoD was higher in CO2 group at postoperative week 2 compared to the control group. CLINICAL SIGNIFICANCE: Transcutaneous CO2 application has the therapeutic potential to accelerate the recovery of muscle atrophy in peripheral nerve injury. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1653-1658, 2018.

  Nov. 2017, J Orthop Res, 36(6) (6), 1653 - 1658, English, International magazine

  [Refereed]

  Scientific journal


• The medial tibial joint line elevation over 5 mm restrained the improvement of knee extension angle in unicompartmental knee arthroplasty

  IshidaK, MuratsuH, KurodaY, TsubosakaM, Hashimoto Shingo, Hayashi Shinya, MatsushitaT, Niikura Takahiro, Kuroda Ryosuke, Matsumoto Tomoyuki

  PURPOSE: The purpose of this study was to examine the relationship between medial tibial joint line elevation and the improvement of range of motion (ROM) in unicompartmental knee arthroplasty (UKA). The hypothesis was that limited elevation of tibial joint line will improve knee range of motion in UKA. METHODS: Forty-six consecutive medial UKAs were enrolled in this study. Medial tibial joint line elevation was defined as the polyethylene insert and tibial tray thickness minus the tibial osteotomy and sawblade thickness. Positive values indicated an elevation of the tibial joint line. A component gap between the femoral trial prosthesis and the medial tibial osteotomy surface was also examined. Joint loosening was also calculated based on the joint component gap minus insert and tibial tray thickness. The correlation of the medial tibial joint line elevation with joint looseness and postoperative range of motion were analyzed. RESULTS: The mean medial tibial joint line elevation was 4.9 ± 1.1 mm. The medial tibial joint line elevation reduced the improvement of knee extension (R = - 0.43, p < 0.01). The medial tibial joint line elevation was also correlated with reduced loosening of the joint knee extension (R = - 0.42, p < 0.01). This, in turn, resulted in limited improvement of the knee extension angle. Moreover, joint line elevation under 5 mm significantly improved knee extension angle compared to joint line elevation over 5 mm. CONCLUSIONS: The medial joint line elevation of the tibia in UKA reduced the improvement of knee extension angle, due to a reduced joint looseness at knee extension. A tibial joint line elevation greater than 5 mm in UKA should be avoided to prevent postoperative flexion contracture. For the clinical relevance, this study clarified that the medial joint line of the tibia is an important factor to prevent postoperative flexion contracture in UKA. LEVEL OF EVIDENCE: II.

  Nov. 2017, Knee Surg Sports Traumatol Arthrosc, 26(6) (6), 1737 - 1742, English, International magazine

  [Refereed]

  Scientific journal


• Synergistic Effects of a Smac Mimetic with Doxorubicin Against Human Osteosarcoma

  Etsuko Kamata, Teruya Kawamoto, Takeshi Ueha, Hitomi Hara, Naomasa Fukase, Masaya Minoda, Masayuki Morishita, Toshiyuki Takemori, Shuichi Fujiwara, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka, Toshihiro Akisue

  Nov. 2017, ANTICANCER RESEARCH, 37(11) (11), 6097 - 6106, English

  [Refereed]

  Scientific journal


• Posterior condylar offset influences the intraoperative soft tissue balance during posterior-stabilized total knee arthroplasty

  Masanori Tsubosaka, Koji Takayama, Shinya Oka, Hirotsugu Muratsu, Ryosuke Kuroda, Tomoyuki Matsumoto

  Nov. 2017, JOURNAL OF ORTHOPAEDIC SCIENCE, 22(6) (6), 1071 - 1076, English

  [Refereed]

  Scientific journal


• 反復性膝蓋骨脱臼患者における内側膝蓋大腿靱帯再建術前後の膝伸展筋力の変化

  松下 雄彦, 荒木 大輔, 星野 祐一, 柴田 洋平, 上田 雄也, 宮地 伸晃, 寛島 佑史, 山下 貴大, 茨木 一行, 神崎 至幸, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2017, 日本臨床スポーツ医学会誌, 25(4) (4), S193 - S193, Japanese


• 化膿性肩関節炎に対する治療経験

  名倉 一成, 金谷 貴子, 原田 義文, 乾 淳幸, 美舩 泰, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2017, 日本肩関節学会抄録集, 44回, 195 - 195, Japanese


• 投球動作における肩関節周囲筋組織弾性の経時的変化

  山裏 耕平, 美舩 泰, 乾 淳幸, 黒澤 尭, 片岡 武史, 植田 安洋, 西本 華子, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2017, 日本肩関節学会抄録集, 44回, 326 - 326, Japanese


• CAT・HFTと肩後方筋群の弾性率の関係

  美舩 泰, 乾 淳幸, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 尭, 山裏 耕平, 国分 毅, 黒田 良祐

  (一社)日本肩関節学会, Oct. 2017, 日本肩関節学会抄録集, 44回, 330 - 330, Japanese


• 超音波装置を用いた野球選手の肘内側側副靱帯の観察

  乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒澤 尭, 山裏 耕平, 黒田 良祐, 国分 毅

  (一社)日本肩関節学会, Oct. 2017, 日本肩関節学会抄録集, 44回, 331 - 331, Japanese


• 膝前十字靱帯再建術 Joint Instability Measurement Interfaceの開発経験より

  黒田 良祐, 星野 祐一, 荒木 大輔, 神崎 至幸, 松下 雄彦

  (一社)日本臨床スポーツ医学会, Oct. 2017, 日本臨床スポーツ医学会誌, 25(4) (4), S169 - S169, Japanese


• 前十字靱帯損傷に合併した半月板損傷は前十字靱帯再建術術後に潜在的Pivot-Shiftを残存させる要因となる

  星野 祐一, 宮地 伸晃, 寛島 佑史, 山下 貴大, 茨木 一行, 田中 聡一, 西田 京平, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2017, 日本臨床スポーツ医学会誌, 25(4) (4), S245 - S245, Japanese


• 前外側関節包損傷を合併する前十字靱帯損傷に対する前十字靱帯単独再建 術後1年における回旋不安定性の影響

  寛島 佑史, 星野 祐一, 宮地 伸晃, 茨木 一行, 田中 聡一, 西田 京平, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2017, 日本臨床スポーツ医学会誌, 25(4) (4), S246 - S246, Japanese


• 前十字靱帯単独損傷患者における回旋不安定性に対する性別の影響

  宮地 伸晃, 松下 雄彦, 星野 祐一, 寛島 佑史, 荒木 大輔, 西田 京平, 山下 貴大, 田中 聡一, 茨木 一行, 神崎 至幸, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2017, 日本臨床スポーツ医学会誌, 25(4) (4), S247 - S247, Japanese


• 当科における足関節外側靱帯損傷に対する鏡視下外側靱帯修復術

  山下 貴大, 神崎 至幸, 寛島 佑史, 宮地 伸晃, 茨木 一行, 田中 聡一, 西田 京平, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2017, 日本臨床スポーツ医学会誌, 25(4) (4), S252 - S252, Japanese


• 前十字靱帯再建術後のスポーツ復帰に対する満足度と関連する要因の検討

  上田 雄也, 松下 雄彦, 柴田 洋平, 瀧口 耕平, 荒木 大輔, 神崎 至幸, 星野 祐一, 酒井 良忠, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2017, 日本臨床スポーツ医学会誌, 25(4) (4), S181 - S181, Japanese


• Analysis of the influence of anaesthesia on the clinical and quantitative assessment of the pivot shift: a multicenter international study.

  Nicola Lopomo, Cecilia Signorelli, Amir Ata Rahnemai-Azar, Federico Raggi, Yuichi Hoshino, Kristian Samuelsson, Volker Musahl, Jon Karlsson, Ryosuke Kuroda, Stefano Zaffagnini

  PURPOSE: The main goal of this work was to evaluate the pivot shift test in awake and anesthetized patients by using two different quantitative methodologies and comparing the results with the standard clinical grading, taking advantage of a multicenter international study. METHODS: Patients between 16 and 50 years of age undergoing primary unilateral single-bundle anterior cruciate ligament (ACL) reconstruction were considered eligible. The pivot shift test was performed pre-operatively, with the patient awake and again with the patient under general anaesthesia. The pivot shift test was clinically graded as defined by the International Knee Documentation Committee. The instrumented assessment was performed by using two non-invasive acquisition systems; specifically, a system exploiting an inertial sensor and a video-based application developed on a commercial tablet using skin markers. Lateral compartment translation and the tibial acceleration reached during joint reduction were used as quantitative parameters. RESULTS: A total of 103 patients were enrolled in the study. Statistically significant difference was found between the distributions of clinical grade evaluated in awake patients and those under general anaesthesia (P < 0.01). Comparing awake patients to those under general anaesthesia, lower values were found both for tibial acceleration (3.7 ± 1.5 vs 6.0 ± 4.6 m/s2, P < 0.01) and lateral compartment translation of the involved limb (2.2 ± 1.7 vs 3.0 ± 2.2 mm, P < 0.01). CONCLUSIONS: This study indicated that significant differences in the grading of the pivot shift test exist between awake and anesthetized patients, regardless of the use of quantitative instruments during the evaluation. Actual clinical assessment reported indeed its weakness, presenting subjective variability and dependence on tester's experience. However, several factors might influence the validity of awake examination such as experience level of examiner and cultural factors, as seen in this international multicenter study. LEVEL OF EVIDENCE: Prospective comparative study, Level II.

  Oct. 2017, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 25(10) (10), 3004 - 3011, English, International magazine

  [Refereed]

  Scientific journal


• Factors affecting quadriceps strength recovery after anterior cruciate ligament reconstruction with hamstring autografts in athletes.

  Yuya Ueda, Takehiko Matsushita, Daisuke Araki, Akihiro Kida, Kohei Takiguchi, Yohei Shibata, Kumiko Ono, Rei Ono, Tomoyuki Matsumoto, Koji Takayama, Yoshitada Sakai, Masahiro Kurosaka, Ryosuke Kuroda

  PURPOSE: Patients typically return to sports activities 6-12 months after anterior cruciate ligament (ACL) reconstruction, and quadriceps strength has been used as one of the criteria to return to sports activities. The purpose of this study is to identify the factors that affect quadriceps strength recovery after ACL reconstruction with a hamstring tendon autograft 6 months after surgery. METHODS: Isokinetic quadriceps strength at 60°/s was measured preoperatively and 6 months after surgery in 193 athletes who underwent ACL reconstruction with a hamstring tendon autograft. The quadriceps strength index was calculated by normalizing the peak torque of the involved leg with the uninvolved leg. The subjects were divided into two groups according to the quadriceps strength index 6 months after surgery: at least 85 % (n = 84) or less than 85 % (n = 109). Multivariate logistic regression analysis and a receiver operating curve analysis were performed. RESULTS: The preoperative quadriceps strength index [odds ratio (OR) 1.02; 95 % confidence interval (CI) 1.01-1.03], age (OR 0.92; 95 % CI 0.86-0.98), sex (OR 2.45; 95 % CI 1.19-5.18), and knee pain (OR 0.17; 95 % CI 0.04-0.52) were independently associated with quadriceps strength recovery. The cut-off value of the preoperative quadriceps strength index was 70.2 % to obtain at least 85 % quadriceps strength index 6 months after surgery. CONCLUSION: To achieve sufficient quadriceps strength recovery at the timing of return to sports activities following ACL reconstruction using a hamstring tendon autograft, preoperative quadriceps strength, age, sex, and knee pain should be considered. LEVEL OF EVIDENCE: III.

  Oct. 2017, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 25(10) (10), 3213 - 3219, English, International magazine

  [Refereed]

  Scientific journal


• Prospective Cohort Study of Performance Status and Activities of Daily Living After Surgery for Spinal Metastasis.

  Kenichiro Kakutani, Yoshitada Sakai, Koichiro Maeno, Toru Takada, Takashi Yurube, Takuto Kurakawa, Shingo Miyazaki, Yoshiki Terashima, Masaaki Ito, Hitomi Hara, Teruya Kawamoto, Yasuo Ejima, Akihiro Sakashita, Naomi Kiyota, Yoshiyuki Kizawa, Ryohei Sasaki, Toshihro Akisue, Hironobu Minami, Ryosuke Kuroda, Masahiro Kurosaka, Kotaro Nishida

  STUDY DESIGN: A prospective cohort study of performance status (PS) and activities of daily living (ADL) in patients with spinal metastasis. OBJECTIVE: To identify the effect of spinal surgery on PS and ADL in patients with spinal metastasis. SUMMARY OF BACKGROUND DATA: Spinal metastasis causes severe neurological deficits, resulting in drastic loss of patients' PS and ADL. However, the effect of spine surgery on PS and ADL is not well known. MATERIALS AND METHODS: Seventy patients with spinal metastasis were enrolled in this study. Forty-six patients desired and underwent spine surgery ("surgery" group) and 24 patients did not desire surgery ("nonsurgery" group). Both groups received optimal treatments, including radiation, chemotherapy, and palliative care services. Evaluation was performed at 1, 3, and 6 months after study enrollment using the Eastern Cooperative Oncology Group PS, the Barthel index (BI) for ADL, and Frankel classification for neurological status. RESULTS: There was no significant difference in baseline PS, the BI, or Frankel classification between the groups. The surgery group showed significant improvement in PS, maintaining grade 2 or less throughout the duration of the study, as well as in ADL, exceeding 70 points of the BI, compared with the nonsurgery group (P<0.05). Significantly improved neurological condition was also observed in the surgery group over the following 6 months. More than 95% of patients who underwent surgery improved their PS, the BI, and neurological status. Furthermore, >80% of these patients maintained improvement in PS, the BI, and neurological status for at least 6 months. In contrast, PS, the BI, and neurological status of patients in the "nonsurgery" group deteriorated throughout the study period. CONCLUSIONS: Spine surgery improves PS, ADL, and neurological status in patients with spinal metastasis for a minimum 6 months. This indicates that these patients can acquire an independent daily life.

  Oct. 2017, Clinical spine surgery, 30(8) (8), E1026-E1032, English, International magazine

  [Refereed]

  Scientific journal


• The Influence of Joint Distraction Force on the Soft-Tissue Balance Using Modified Gap-Balancing Technique in Posterior-Stabilized Total Knee Arthroplasty

  Kanto Nagai, Hirotsugu Muratsu, Yoshiki Takeoka, Masanori Tsubosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  Oct. 2017, Journal of Arthroplasty, 32(10) (10), 2995 - 2999, English

  [Refereed]

  Scientific journal


• Radiographic analysis of the lower limbs using the hipcalcaneus line in healthy individuals and in patients with varus knee osteoarthritis

  Toshikazu Tanaka, Koji Takayama, Shingo Hashimoto, Noriyuki Kanzaki, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  Oct. 2017, KNEE, 24(5) (5), 1146 - 1152, English

  [Refereed]

  Scientific journal


• "Back to the future": a historical perspective on the role of extra-articular reconstruction

  Andrew J. Sheean, Ryosuke Kuroda, Stefano Zaffagnini, Volker Musahl

  Oct. 2017, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 25(10) (10), 2989 - 2992, English

  [Refereed]

  Scientific journal


• 腰椎椎体骨折におけるTrabecular Bone Score(TBS)とBMDの比較 TBSの骨折予測因子としての働き

  西本 華子, 乾 淳幸, 美舩 泰, 楊 鴻生, 酒井 良忠, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2017, 中部日本整形外科災害外科学会雑誌, 60(秋季学会) (秋季学会), 144 - 144, Japanese


• 尺骨肘頭骨折に対するプレート固定術の治療成績

  黒澤 尭, 乾 淳幸, 美舩 泰, 西本 華子, 黒田 司, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2017, 中部日本整形外科災害外科学会雑誌, 60(秋季学会) (秋季学会), 241 - 241, Japanese


• 腰椎椎体骨折におけるTrabecular Bone Score(TBS)とBone Mineral Density(BMD)の比較 腰椎椎体骨折におけるTBSの骨折予測因子としての働き

  西本 華子, 乾 淳幸, 美舩 泰, 片岡 武史, 鷲見 正敏, 酒井 良忠, 黒田 良祐, 楊 鴻生

  (一社)日本骨粗鬆症学会, Sep. 2017, 日本骨粗鬆症学会雑誌, 3(Suppl.1) (Suppl.1), 298 - 298, Japanese


• 若年成人に発生した非定型大腿骨骨折の3例

  李 相亮, 新倉 隆宏, 岩倉 崇, 乾 淳幸, 黒田 良祐, 酒井 良忠

  (一社)日本骨粗鬆症学会, Sep. 2017, 日本骨粗鬆症学会雑誌, 3(Suppl.1) (Suppl.1), 347 - 347, Japanese


• 野球選手における肘内側側副靱帯のエコー装置による観察

  乾 淳幸, 美舩 泰, 西本 華子, 植田 安洋, 片岡 武史, 黒田 良祐

  (公社)日本リハビリテーション医学会, Sep. 2017, The Japanese Journal of Rehabilitation Medicine, 54(秋季特別号) (秋季特別号), S257 - S257, Japanese


• 腰椎椎体骨折におけるTrabecular Bone Score(TBS)とBone Mineral Density(BMD)の比較

  西本 華子, 乾 淳幸, 井上 美帆, 植田 安洋, 片岡 武史, 岩本 安理, 美舩 泰, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, Sep. 2017, The Japanese Journal of Rehabilitation Medicine, 54(秋季特別号) (秋季特別号), S257 - S257, Japanese


• 前十字靱帯不全膝における術前待機期間がpivot shift test脛骨整復時の加速度に及ぼす影響

  西田 京平, 松下 雄彦, 荒木 大輔, 神崎 至幸, 星野 祐一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2017, 中部日本整形外科災害外科学会雑誌, 60(秋季学会) (秋季学会), 83 - 83, Japanese


• Decoy receptor 3は関節リウマチ滑膜細胞におけるCentrosomal protein 70kDaの発現を抑制する

  福田 康治, 三浦 靖史, 前田 俊恒, 林 申也, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2017, 中部日本整形外科災害外科学会雑誌, 60(秋季学会) (秋季学会), 123 - 123, Japanese

  [Refereed]


• 当院における骨転移リハビリテーションの現状とリハ介入因子の検討

  伊達 安理, 仲山 舞, 小林 慶通, 角谷 賢一朗, 井上 美帆, 西本 華子, 福田 康治, 原 仁美, 秋末 敏宏, 黒田 良祐, 酒井 良忠

  (公社)日本リハビリテーション医学会, Sep. 2017, The Japanese Journal of Rehabilitation Medicine, 54(秋季特別号) (秋季特別号), S273 - S273, Japanese

  [Refereed]


• Pseudoaneurysm of the articular branch of the descending genicular artery following double-bundle anterior cruciate ligament reconstruction

  Masanori Tsubosaka, Takehiko Matsushita, Ryosuke Kuroda, Tomoyuki Matsumoto, Masahiro Kurosaka

  Springer Verlag, Sep. 2017, Knee Surgery, Sports Traumatology, Arthroscopy, 25(9) (9), 2721 - 2724, English

  [Refereed]

  Scientific journal


• Stem anteversion mismatch to the anatomical anteversion causes loss of periprosthetic bone density after THA

  Hayashi Shinya, Hashimoto Shingo, Matsumoto Tomoyuki, TakayamaK, NishidaK, IshidaK, Kuroda Ryosuke

  Sep. 2017, J Orthop Surg (Hong Kong), 25(3) (3), 2309499017739478, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Risk factors for failure of revision total hip arthroplasty using a Kerboull-type acetabular reinforcement device

  Shinya Hayashi, Takayuki Nishiyama, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Kazunari Ishida, Kotaro Nishida, Ryosuke Kuroda

  Sep. 2017, BMC MUSCULOSKELETAL DISORDERS, 18(1) (1), 382, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A development of measurement system for walking with turning using 6-axis inertial sensors and its reliability evaluation

  Yuki Azuma, Kouki Nagamune, Ryosuke Kuroda

  Institute of Electrical and Electronics Engineers Inc., Aug. 2017, IFSA-SCIS 2017 - Joint 17th World Congress of International Fuzzy Systems Association and 9th International Conference on Soft Computing and Intelligent Systems, English

  [Refereed]

  International conference proceedings


• 不動化に伴う骨格筋内脂肪細胞浸潤と脂肪組織炎症の検討

  片岡 武史, 乾 淳幸, 美舩 泰, 坂田 亮介, 西本 華子, 高瀬 史明, 植田 安洋, 黒澤 尭, 国分 毅, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1862 - S1862, Japanese


• ウサギ腱板広範囲断裂モデルにおける大腿筋膜移植補強術の修復部の治癒促進効果の検討

  片岡 武史, 国分 毅, 無藤 智之, 美舩 泰, 乾 淳幸, 西本 華子, 高瀬 史明, 植田 安洋, 黒澤 尭, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1866 - S1866, Japanese


• 腱炎における老化の影響の検討

  植田 安洋, 乾 淳幸, 美舩 泰, 国分 毅, 高瀬 史明, 片岡 武史, 黒澤 尭, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1869 - S1869, Japanese


• 高血糖ストレスモデルを用いたラット腱細胞におけるアポシニンの抗酸化作用の検討

  黒澤 尭, 美舩 泰, 乾 淳幸, 植田 安洋, 片岡 武史, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1870 - S1870, Japanese


• ACL損傷膝に合併する前外側関節包損傷のMRI評価の限界

  宮地 伸晃, 星野 祐一, 茨木 一行, 田中 聡一, 西田 京平, 西澤 勇一郎, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (一社)日本整形外科スポーツ医学会, Aug. 2017, 日本整形外科スポーツ医学会雑誌, 37(4) (4), 394 - 394, Japanese


• 前十字靱帯損傷に生じる膝回旋不安定性に及ぼす半月板合併損傷の影響

  星野 祐一, 宮地 伸晃, 田中 聡一, 西田 京平, 西澤 勇一郎, 荒木 大輔, 松下 雄彦, 黒田 良祐

  (一社)日本整形外科スポーツ医学会, Aug. 2017, 日本整形外科スポーツ医学会雑誌, 37(4) (4), 522 - 522, Japanese


• 三次元CTを用いたquadrant法による膝前十字靱帯解剖学的二重束再建術後骨孔評価方法の信頼性の検討

  宮地 伸晃, 荒木 大輔, 松下 雄彦, 神崎 至幸, 星野 祐一, 茨木 一行, 田中 聡一, 西田 京平, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1800 - S1800, Japanese


• 前十字靱帯損傷後の遺残組織の形態の差異が治癒特性に与える影響

  桐月 伸輔, 松本 知之, 黒田 雄一, 竹内 一裕, 羽田 勝彦, 井口 貴雄, 高山 孝治, 荒木 大輔, 橋本 慎吾, 林 申也, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1874 - S1874, Japanese


• 尺骨近位部骨折に対するプレート固定術の治療成績

  黒澤 尭, 乾 淳幸, 美舩 泰, 高瀬 史明, 植田 安洋, 片岡 武史, 黒田 司, 黒田 良祐

  (一社)日本骨折治療学会, Jul. 2017, 骨折, 39(Suppl.) (Suppl.), S364 - S364, Japanese


• Masquelet法による再建を行った化膿性手関節炎の1例

  乾 淳幸, 美舩 泰, 黒澤 尭, 黒田 良祐

  (一社)日本骨折治療学会, Jul. 2017, 骨折, 39(Suppl.) (Suppl.), S423 - S423, Japanese


• mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging.

  Koji Takayama, Yohei Kawakami, Mitra Lavasani, Xiaodong Mu, James H Cummins, Takashi Yurube, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H Fu, Paul D Robbins, Laura J Niedernhofer, Johnny Huard

  Mice expressing reduced levels of ERCC1-XPF (Ercc1-/Δ mice) demonstrate premature onset of age-related changes due to decreased repair of DNA damage. Muscle-derived stem/progenitor cells (MDSPCs) isolated from Ercc1-/Δ mice have an impaired capacity for cell differentiation. The mammalian target of rapamycin (mTOR) is a critical regulator of cell growth in response to nutrient, hormone, and oxygen levels. Inhibition of the mTOR pathway extends the lifespan of several species. Here, we examined the role of mTOR in regulating the MDSPC dysfunction that occurs with accelerated aging. We show that mTOR signaling pathways are activated in Ercc1-/Δ MDSPCs compared with wild-type (WT) MDSPCs. Additionally, inhibiting mTOR with rapamycin promoted autophagy and improved the myogenic differentiation capacity of the Ercc1-/Δ MDSPCs. The percent of apoptotic and senescent cells in Ercc1-/Δ MDSPC cultures was decreased upon mTOR inhibition. These results establish that mTOR signaling contributes to stem cell dysfunction and cell fate decisions in response to endogenous DNA damage. Therefore, mTOR represents a potential therapeutic target for improving defective, aged stem cells. © 2016 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society. J Orthop Res 35:1375-1382, 2017.

  Jul. 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 35(7) (7), 1375 - 1382, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Relatively Loose Flexion Gap Improves Patient-Reported Clinical Scores in Cruciate-Retaining Total Knee Arthroplasty

  Matsumoto Tomoyuki, MuratsuH, IshidaK, Hashimoto Shingo, Hayashi Shinya, Kuroda Ryosuke

  Although appropriate soft tissue balancing is well recognized as essential procedure in total knee arthroplasty (TKA), poor relationship between intraoperative soft tissue balance and physician-reported clinical outcomes was reported. Since physician-derived scores are reported to be poorly related to patient-reported scores, patient-derived outcome scales have received a great deal of attention and have become increasingly important. Thus, it should be clarified whether intraoperative soft tissue balance influences patient-reported clinical outcomes. Therefore, the purpose of this study was to investigate the relationship between intraoperative soft tissue balance and patient-reported clinical outcomes in TKA. A total of 35 TKAs were performed in patients with varus-type osteoarthritis, using the tibia first technique with a navigation system. Soft tissue balance (joint component gap and varus/valgus ligament balance) with femoral component placement and temporarily repaired patellofemoral joint were intraoperatively assessed with an offset-type tensor under 40 lb of joint distraction force. Measurements were performed at 0, 10, 30, 60, 90, and 120 degrees of knee flexion. Subjective clinical outcomes were assessed using the 2011 Knee Society score, which consists of objective knee indicators, patient satisfaction, patient expectations, and functional activities at the minimum 1-year follow-up. The relationship between each parameter in soft tissue balance and subjection clinical score was assessed using a simple linear regression model. Objective knee indicators, especially patient-reported symptoms, showed positive correlations with joint component gap difference of 90 to 0 and 120 to 0 degrees. Patient satisfaction and expectations also exhibited positive correlations with joint component gap difference of 90 to 0 and 120 to 0 degrees. There were no correlations among any parameters of soft tissue balance and functional activities. The other parameters, including varus/valgus ligament balance, showed no statistical correlations with clinical scores. In conclusion, intraoperative soft tissue balance influenced the postoperative clinical outcomes, where a relatively loose flexion gap resulted in higher scores for the parameters of pain, patient satisfaction, and patient expectations.

  Jul. 2017, J Knee Surg, 31(6) (6), 573 - 579, English, International magazine

  [Refereed]

  Scientific journal


• Clinical Experience With the Use of Low-Intensity Pulsed Ultrasound (LIPUS) in the Treatment of Atypical Femoral Fractures

  LeeSY, Niikura Takahiro, IwakuraT, FukuiT, Kuroda Ryosuke

  OBJECTIVE: The aim of this study was to report the clinical results of atypical femoral fractures (AFFs) treated with low-intensity pulsed ultrasound (LIPUS). MATERIALS AND METHODS: The data on AFFs that were surgically treated in our hospital from 2010 to 2016 was retrospectively analyzed. AFF was diagnosed based on the criteria defined by the second report of an ASBMR task force. RESULTS: Seven fractures in 6 cases were included in this study. Two fractures were referred to us as being nonunion. Five fractures were subtrochanteric fractures and 2 fractures were shaft fractures. Five fresh AFFs were fixed with an intramedullary nail and 2 nonunion fractures were fixed with plates. LIPUS was used in 6 fractures. Bone union was achieved in 5 fractures with the average time to union being 17 months (5-29). In 4 out of the 6 fractures treated with LIPUS, bone union was achieved after 14 months on average. In the other 2 LIPUS-treated fractures, bone union was not achieved even at 1 year after surgery. DISCUSSION: It is known that AFF healing tends to be very slow. Some case reports indicate that AFF healing might be accelerated by LIPUS. In the current series, the subtrochanteric fracture that was not treated with LIPUS healed at 29 months after surgery, which was much longer than the average time to union in the 5 fractures that were treated with LIPUS. Although our number of cases is small, LIPUS may be a potentially useful tool for accelerating AFF repair.

  Jul. 2017, J Orthop Trauma, 31(7) (7), S2, English, International magazine

  Symposium


• マウス変形性関節症モデルに対するシンバスタチン含有ゼラチンハイドロゲル関節内投与による関節症進行抑制効果

  田中 聡一, 松下 雄彦, 宮地 伸晃, 茨木 一行, 西田 京平, 荒木 大輔, 神崎 至幸, 田畑 泰彦, 黒田 良祐

  日本DDS学会, Jun. 2017, 日本DDS学会学術集会プログラム予稿集, 33回, 206 - 206, Japanese


• Lumbar spondylolysis: A report of four cases from two generations of a family

  Takashi Yurube, Kenichiro Kakutani, Koji Okamoto, Michihiko Manabe, Koichiro Maeno, Masaho Yoshikawa, Norihide Sha, Ryosuke Kuroda, Kotaro Nishida

  Jun. 2017, JOURNAL OF ORTHOPAEDIC SURGERY, 25(2) (2), English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effects of Suture and Tourniquet on Intraoperative Kinematics in Navigated Total Knee Arthroplasty

  Masanori Tsubosaka, Kazunari Ishida, Hiroshi Sasaki, Nao Shibanuma, Ryosuke Kuroda, Tomoyuki Matsumoto

  Churchill Livingstone Inc., Jun. 2017, Journal of Arthroplasty, 32(6) (6), 1824 - 1828, English

  [Refereed]

  Scientific journal


• Comparison Between Intra- and Extra-articular Tension of the Graft During Fixation in Anterior Cruciate Ligament Reconstruction

  Yuichiro Nishizawa, Yuichi Hoshino, Kouki Nagamune, Daisuke Araki, Kanto Nagai, Masahiro Kurosaka, Ryosuke Kuroda

  Jun. 2017, Arthroscopy - Journal of Arthroscopic and Related Surgery, 33(6) (6), 1204 - 1210, English

  [Refereed]

  Scientific journal


• Quality of life and cost-utility of surgical treatment for patients with spinal metastases: prospective cohort study

  Shingo Miyazaki, Kenichiro Kakutani, Yoshitada Sakai, Yasuo Ejima, Koichiro Maeno, Toru Takada, Takashi Yurube, Yoshiki Terashima, Masaaki Ito, Yuji Kakiuchi, Yoshiki Takeoka, Hitomi Hara, Teruya Kawamoto, Akihiro Sakashita, Takuya Okada, Naomi Kiyota, Yoshiyuki Kizawa, Ryohei Sasaki, Toshihiro Akisue, Hironobu Minami, Ryosuke Kuroda, Kotaro Nishida

  Jun. 2017, INTERNATIONAL ORTHOPAEDICS, 41(6) (6), 1265 - 1271, English

  [Refereed]

  Scientific journal


• Patient-based outcomes after medial patellofemoral ligament reconstruction

  Takehiko Matsushita, Shinya Oka, Daisuke Araki, Kyohei Nishida, Toshikazu Tanaka, Noriyuki Kanzaki, Kotaro Nishida, Ryosuke Kuroda

  Jun. 2017, INTERNATIONAL ORTHOPAEDICS, 41(6) (6), 1147 - 1153, English

  [Refereed]

  Scientific journal


• Optimization of antitumor treatment conditions for transcutaneous CO2 application: An in vivo study

  Takeshi Ueha, Teruya Kawamoto, Yasuo Onishi, Risa Harada, Masaya Minoda, Mitsunori Toda, Hitomi Hara, Naomasa Fukase, Masahiro Kurosaka, Ryosuke Kuroda, Toshihiro Akisue, Yoshitada Sakai

  Jun. 2017, ONCOLOGY REPORTS, 37(6) (6), 3688 - 3694, English

  [Refereed]

  Scientific journal


• Increase in carbon dioxide accelerates the performance of endurance exercise in rats

  UehaT, MiwaM, Hasegawa Takumi, KohA, NishimotoH, LeeSY, Niikura Takahiro, KurosakaM, Kuroda Ryosuke, Sakai Yoshitada

  Endurance exercise generates CO2 via aerobic metabolism; however, its role remains unclear. Exogenous CO2 by transcutaneous delivery promotes muscle fibre-type switching to increase endurance power in skeletal muscles. Here we determined the performance of rats running in activity wheels with/without transcutaneous CO2 exposure to clarify its effect on endurance exercise and recovery from muscle fatigue. Rats were randomised to control, training and CO2 groups. Endurance exercise included activity-wheel running with/without transcutaneous CO2 delivery. Running performance was measured after exercise initiation. We also analysed changes in muscle weight and muscle fibres in the tibialis anterior muscle. Running performance improved over the treatment period in the CO2 group, with a concomitant switch in muscle fibres to slow-type. The mitochondrial DNA content and capillary density in the CO2 group increased. CO2 was beneficial for performance and muscle development during endurance exercise: it may enhance recovery from fatigue and support anabolic metabolism in skeletal muscles.

  Jun. 2017, J Physiol Sci, 68(4) (4), 463 - 470, English, Domestic magazine

  [Refereed]

  Scientific journal


• Altered expression of SDF-1 and CXCR4 during fracture healing in diabetes mellitus

  Michio Arakura, Sang Yang Lee, Shunsuke Takahara, Etsuko Okumachi, Takashi Iwakura, Tomoaki Fukui, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda, Takahiro Niikura

  Jun. 2017, INTERNATIONAL ORTHOPAEDICS, 41(6) (6), 1211 - 1217, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Factors associated with the status of meniscal tears following meniscal repair concomitant with anterior cruciate ligament reconstruction

  Takehiko Matsushita, Kanto Nagai, Daisuke Araki, Toshikazu Tanaka, Tomoyuki Matsumoto, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda

  May 2017, Connective Tissue Research, 58(3-4) (3-4), 386 - 392, English

  [Refereed]

  Scientific journal


• Assessment in primary TKA: Intraoperative assessment tensor

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Ryosuke Kuroda

  May 2017, Soft Tissue Balancing in Total Knee Arthroplasty, 153 - 169

  In book


• 遅筋・速筋におけるラット骨格筋由来間葉系幹細胞の比較検討

  李 相亮, 岩倉 崇, 脇 貴洋, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2017, The Japanese Journal of Rehabilitation Medicine, 54(特別号) (特別号), 1 - 3, Japanese


• Parathyroid hormone(1-34)間歇投与はラット難治性骨折における骨癒合を促進させる

  李 相亮, 脇 貴洋, 岩倉 崇, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2017, The Japanese Journal of Rehabilitation Medicine, 54(特別号) (特別号), 1 - 4, Japanese


• 脳性麻痺および重症心身障害児におけるDynamic Elastomeric Fabric Orthosisの効果

  井上 美帆, 酒井 良忠, 原田 理沙, 赤羽 志保, 西本 華子, 上羽 岳志, 金澤 慎一郎, 黒田 良祐, 佐浦 隆一

  (公社)日本リハビリテーション医学会, May 2017, The Japanese Journal of Rehabilitation Medicine, 54(特別号) (特別号), 3 - 6, Japanese


• 骨盤骨腫瘍に対して腫瘍切除後にHip transposition法を施行した2例

  原 仁美, 秋末 敏宏, 森下 雅之, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2017, The Japanese Journal of Rehabilitation Medicine, 54(特別号) (特別号), 3 - 7, Japanese


• 肩腱板不全断裂に対するアンカーを用いた鏡視下修復術の検討

  国分 毅, 美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 片岡 武史, 黒澤 尭, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 461 - 461, Japanese


• 四肢骨格筋量は高齢者女性QOLに影響を及ぼすのか? 骨格筋指数とEQ-5Dを用いたQOL評価

  西本 華子, 乾 淳幸, 美舩 泰, 片岡 武史, 酒井 良忠, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 601 - 601, Japanese


• 超音波検査による投球障害肩を引き起こす因子の検討

  片岡 武史, 美舩 泰, 乾 淳幸, 西本 華子, 高瀬 史明, 植田 安洋, 国分 毅, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 819 - 819, Japanese


• CAT・HFTと肩後方筋群の弾性率の関係

  美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 片岡 武史, 黒澤 尭, 西本 華子, 国分 毅, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 820 - 820, Japanese


• Combined Abduction TestおよびHorizontal Flexion Testと肩後方筋群の弾性率の関係

  美舩 泰, 乾 淳幸, 片岡 武史, 酒井 良忠, 秋末 敏宏, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2017, The Japanese Journal of Rehabilitation Medicine, 54(特別号) (特別号), 1 - 2, Japanese


• 野球選手における超音波検査を用いた筋弾性率と筋厚の評価

  片岡 武史, 美舩 泰, 乾 淳幸, 酒井 良忠, 秋末 敏宏, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2017, The Japanese Journal of Rehabilitation Medicine, 54(特別号) (特別号), 1 - 3, Japanese


• ACL再建術後の動的不安定性残像の撲滅を目指して 残存する動的不安定性の撲滅のためのPivot shift testの客観・定量的評価

  星野 祐一, 宮地 伸晃, 田中 聡一, 西田 京平, 荒木 大輔, 松下 雄彦, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 239 - 239, Japanese


• ACL再建術後の動的不安定性残像の撲滅を目指して 膝関節前外側支持機構の生体力学的解析 屍体膝実験からの知見をふまえて

  荒木 大輔, 松下 雄彦, 星野 祐一, 神崎 至幸, 西田 京平, 田中 聡一, 宮地 伸晃, 茨木 一行, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 240 - 240, Japanese


• 関節の再生医療2017 軟骨細胞による再生医療

  黒田 良祐, 松下 雄彦, 松本 知之, 星野 祐一, 神崎 至幸, 荒木 大輔

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 247 - 247, Japanese


• 内側開大型高位脛骨骨切り術前後における膝蓋大腿関節の軟骨損傷の変化

  田中 聡一, 松下 雄彦, 岡 真也, 宮地 伸晃, 茨木 一行, 西田 京平, 荒木 大輔, 神崎 至幸, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 318 - 318, Japanese


• ノットレスアンカーを用いた鏡視下足関節外側靱帯修復術

  神崎 至幸, 茨木 一行, 宮地 伸晃, 田中 聡一, 西田 京平, 荒木 大輔, 松下 雄彦, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 416 - 416, Japanese


• アキレス腱付着部障害に対してsuture bridge法にPercutaneous Achilles Repair System(PARS)を併用して加療した1例

  茨木 一行, 神崎 至幸, 宮地 伸晃, 田中 聡一, 西田 京平, 荒木 大輔, 星野 祐一, 松下 雄彦, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 418 - 418, Japanese


• 前十字靱帯不全膝における術前待機期間がpivot shift test脛骨整復時の加速度に及ぼす影響

  西田 京平, 松下 雄彦, 荒木 大輔, 田中 聡一, 宮地 伸晃, 茨木 一行, 神崎 至幸, 星野 祐一, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 559 - 559, Japanese


• 三次元CTを用いたQuadrant法による膝前十字靱帯解剖学的二重束再建術後骨孔評価方法の信頼性の検討

  宮地 伸晃, 荒木 大輔, 松下 雄彦, 神崎 至幸, 星野 祐一, 茨木 一行, 田中 聡一, 西田 京平, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 696 - 696, Japanese


• Multiple Revision Surgeries and Acetabular Bone Defect Size May Predict Daily Activity After Revision Total Hip Arthroplasty

  Shinya Hayashi, Shingo Hashimoto, Koji Takayama, Tomoyuki Matsumoto, Kotaro Nishida, Ryosuke Kuroda

  Churchill Livingstone Inc., May 2017, Journal of Arthroplasty, 32(5) (5), 1606 - 1611, English

  [Refereed]

  Scientific journal


• Cyclin-Dependent Kinase Inhibitor-1-Deficient Mice are Susceptible to Osteoarthritis Associated with Enhanced Inflammation

  Shinsuke Kihara, Shinya Hayashi, Shingo Hashimoto, Noriyuki Kanzaki, Koji Takayama, Tomoyuki Matsumoto, Nobuaki Chinzei, Kenjiro Iwasa, Masahiko Haneda, Kazuhiro Takeuchi, Kotaro Nishida, Ryosuke Kuroda

  John Wiley and Sons Inc., May 2017, Journal of Bone and Mineral Research, 32(5) (5), 991 - 1001, English

  [Refereed]

  Scientific journal


• Transcutaneous carbon dioxide application accelerates muscle injury repair in rat models

  Shiho Akahane, Yoshitada Sakai, Takeshi Ueha, Hanako Nishimoto, Miho Inoue, Takahiro Niikura, Ryosuke Kuroda

  Springer Verlag, May 2017, International Orthopaedics, 41(5) (5), 1007 - 1015, English

  [Refereed]

  Scientific journal


• New proximal femoral compaction blade provides strong antirotation stability of the femoral head

  Shinya Hayashi, Yukiaki Hirata, Daiki Okamoto, Satoshi Kakunai, Shingo Hashimoto, Koji Takayama, Tomoyuki Matsumoto, Takahiro Niikura, Takaaki Fujishiro, Takafumi Hiranaka, Kotaro Nishida, Ryosuke Kuroda

  Slack Incorporated, May 2017, Orthopedics, 40(3) (3), e491 - e494, English

  [Refereed]

  Scientific journal


• Influence of the Injury-to-Surgery Interval on the Healing Potential of Human Anterior Cruciate Ligament-Derived Cells

  Takao Inokuchi, Tomoyuki Matsumoto, Koji Takayama, Naoki Nakano, Shurong Zhang, Daisuke Araki, Takehiko Matsushita, Ryosuke Kuroda

  SAGE Publications Inc., May 2017, American Journal of Sports Medicine, 45(6) (6), 1359 - 1369, English

  [Refereed]

  Scientific journal


• 脊椎椎間板髄核におけるオートファジーの重要性とその誘導による椎間板変性予防の可能性

  伊藤雅明, Kakutani Kenichiro, 前野耕一郎, Kuroda Ryosuke, 西田康太郎

  (一社)中部日本整形外科災害外科学会, May 2017, 中部日本整形外科災害外科学会雑誌, 60(3) (3), 547 - 548, Japanese

  [Refereed]

  Scientific journal


• Radiological and clinical comparison of kinematically versus mechanically aligned total knee arthroplasty

  T. Matsumoto, K. Takayama, K. Ishida, S. Hayashi, S. Hashimoto, R. Kuroda

  May 2017, BONE & JOINT JOURNAL, 99-B(5) (5), 640 - 646, English

  [Refereed]

  Scientific journal


• Kinematically aligned total knee arthroplasty: Alternative standardized technique?

  Tomoyuki Matsumoto, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda

  AME Publishing Company, May 2017, Annals of Translational Medicine, 5(Suppl 1) (Suppl 1), S10, English

  [Refereed]

  Scientific journal


• 膝窩腱を自家移植して前十字靱帯を再建した後の男女における術前の大腿四頭筋筋力で層別化した大腿四頭筋筋力回復度の評価(Evaluation of quadriceps strength recovery stratified preoperative quadriceps strength after anterior cruciate ligament reconstruction with hamstrings autograft in male and female)

  Ueda Yuya, Matsushita Takehiko, Takiguchi Kohei, Shibata Yohei, Ono Kumiko, Ono Rei, Araki Daisuke, Kanzaki Noriyuki, Sakai Yoshitada, Kuroda Ryosuke

  (公社)日本理学療法士協会, Apr. 2017, 理学療法学, 44(Suppl.2) (Suppl.2), O - 1, English


• Pain Visionにより測定した手根管症候群手術前後のしびれの変化

  乾 淳幸, 美舩 泰, 片岡 武史, 西本 華子, 国分 毅, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2017, 中部日本整形外科災害外科学会雑誌, 60(春季学会) (春季学会), 183 - 183, Japanese


• 四肢骨格筋量は高齢者QOLに影響を及ぼすのか? 骨格筋指数とEQ-5Dを用いたQOL評価の相関関係

  西本 華子, 乾 淳幸, 楊 鴻生, 酒井 良忠, 鷲見 正敏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2017, 中部日本整形外科災害外科学会雑誌, 60(春季学会) (春季学会), 206 - 206, Japanese


• 外反型変形性膝関節症患者における大腿骨遠位内反骨切り術の短期術後成績

  宮地 伸晃, 松下 雄彦, 荒木 大輔, 井口 貴雄, 神崎 至幸, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2017, 中部日本整形外科災害外科学会雑誌, 60(春季学会) (春季学会), 72 - 72, Japanese


• がん患者の脊椎転移に対する直視下手術と経皮的後方固定術の全身状態、ADL、QOL改善効果

  由留部 崇, 角谷 賢一朗, 前野 耕一郎, 高田 徹, 黒田 良祐, 西田 康太郎

  (一社)中部日本整形外科災害外科学会, Apr. 2017, 中部日本整形外科災害外科学会雑誌, 60(春季学会) (春季学会), 226 - 226, Japanese

  [Refereed]


• Clinical outcomes and biomechanical analysis of posterolateral bundle augmentation in patients with partial anterior cruciate ligament tears

  Takehiko Matsushita, Ryosuke Kuroda, Yuichiro Nishizawa, Daisuke Araki, Yuichi Hoshino, Kanto Nagai, Tomoyuki Matsumoto, Masahiro Kurosaka

  Apr. 2017, Knee Surgery, Sports Traumatology, Arthroscopy, 25(4) (4), 1279 - 1289, English

  [Refereed]

  Scientific journal


• Tibiofemoral rotational alignment affects flexion angles in navigated posterior-stabilized total knee arthroplasty

  IshidaK, ShibanumaN, Matsumoto Tomoyuki, TodaA, OkaS, KodatoK, KurosakaM, Kuroda Ryosuke

  PURPOSE: To investigate the tibiofemoral rotational profiles during navigated posterior-stabilized (PS) total knee arthroplasty (TKA) and investigate the effect on post-operative maximum flexion angles. METHODS: Twenty-five subjects, treated with navigated PS TKA, were enrolled, and the effect of posterior cruciate ligament (PCL) resection and component implantation on tibiofemoral rotational kinematics was statistically evaluated. Then, the effect of rotational alignment changes on the post-operative maximum angles was retrospectively examined in 96 subjects using the multiple regression analysis. RESULTS: Tibial internal rotation was significantly increased in full extension (p < 0.01 and <0.001, respectively) and at 60° and 90° flexion (p < 0.05) after PCL resection, which further increased after implantation, compared with that before resection. The amount of tibial internal rotation from 90° flexion to maximum flexion was significantly decreased after PCL resection and implantation, compared with that before resection (p < 0.05). The internal changes in the rotational alignment were independent factors for the minimal improvement in the post-operative maximum flexion angles (R 2 = 0.078, p = 0.0067). CONCLUSION: PCL resection changed the tibial rotational alignment and decreased the amount of tibial internal rotation. The implantation of PS components further increased the internal rotational alignment and could not compensate for the tibiofemoral rotation. Finally, the internal changes in rotational alignment affected the improvement of the maximum flexion angles, suggesting that rotational alignment is an important factor for improving post-operative maximum flexion angles. LEVEL OF EVIDENCE: II.

  Apr. 2017, Knee Surg Sports Traumatol Arthrosc, 26(5) (5), 1532 - 1539, English, International magazine

  [Refereed]

  Scientific journal


• Risk factors for late deep infection after total hip arthroplasty in patients with rheumatoid arthritis

  S. Hayashi, Y. Sakai, S. Hashimoto, K. Takayama, T. Matsumoto, K. Takebe, Y. Terashima, K. Ishida, K. Nishida, R. Kuroda

  Apr. 2017, ACTA REUMATOLOGICA PORTUGUESA, 42(2) (2), 150 - 154, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 股関節周囲痛を有した高校サッカー選手の下肢振り動作の特徴について

  松本 慶吾, 伊藤 浩充, 瀧口 耕平, 酒井 良忠, 黒田 良祐, 藤田 健司

  スポーツ選手のためのリハビリテーション研究会, Mar. 2017, Journal of Athletic Rehabilitation, 13(1) (1), 15 - 20, Japanese


• 足関節内反捻挫をした高校サッカー選手の受傷前の身体的特徴について

  瀧口 耕平, 伊藤 浩充, 松本 慶吾, 藤田 健司, 松下 雄彦, 酒井 良忠, 黒田 良祐

  スポーツ選手のためのリハビリテーション研究会, Mar. 2017, Journal of Athletic Rehabilitation, 13(1) (1), 60 - 60, Japanese


• 手根管症候群手術症例における超音波検査を用いた母指球筋萎縮の評価

  名倉 一成, 金谷 貴子, 原田 義文, 鷲見 正敏, 乾 淳幸, 美舩 泰, 国分 毅, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(2) (2), S263 - S263, Japanese


• 前十字靱帯断裂に伴う前外側関節包(ALC)損傷の回旋不安定性に対する影響についての調査

  宮地 伸晃, 星野 祐一, 茨木 一行, 田中 聡一, 西田 京平, 西澤 勇一郎, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  関西関節鏡・膝研究会, Mar. 2017, 関西関節鏡・膝研究会プログラム・演題抄録, 29回, 24 - 24, Japanese


• 膝蓋骨不安定症 高度脱臼素因例に対する治療

  松下 雄彦, 荒木 大輔, 西田 京平, 田中 聡一, 宮地 伸晃, 神崎 至幸, 茨木 一行, 黒田 良祐

  関西関節鏡・膝研究会, Mar. 2017, 関西関節鏡・膝研究会プログラム・演題抄録, 29回, 36 - 36, Japanese


• 前十字靱帯断裂に伴う前外側関節包靱帯損傷の回旋不安定性に対する影響についての検討

  宮地 伸晃, 星野 祐一, 田中 聡一, 西田 京平, 西澤 勇一郎, 荒木 大輔, 神崎 至幸, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(2) (2), S214 - S214, Japanese


• X線透視下大腿骨骨孔位置同定法を用いた内側膝蓋大腿靱帯再建術における再建靱帯の長さ変化

  松下 雄彦, 荒木 大輔, 星野 祐一, 岡 真也, 佐々木 謙, 西澤 勇一郎, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(2) (2), S239 - S239, Japanese


• 足関節外側靱帯損傷に対する鏡視下Brostrom法 われわれの工夫と治療成績

  神崎 至幸, 茨木 一行, 宮地 伸晃, 田中 聡一, 西田 京平, 荒木 大輔, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(3) (3), S1002 - S1002, Japanese


• Biological Augmentation of Anterior Cruciate Ligament Grafts

  Koji Takayama, Ryosuke Kuroda

  W.B. Saunders, Mar. 2017, Operative Techniques in Orthopaedics, 27(1) (1), 33 - 37, English

  [Refereed]

  Scientific journal


• Editorial: “Individualized Anatomical Anterior Cruciate Ligament Reconstruction”

  Sebastián Irarrázaval, Ryosuke Kuroda

  W.B. Saunders, Mar. 2017, Operative Techniques in Orthopaedics, 27(1) (1), 1, English

  [Refereed]

  Scientific journal


• リウマチ性疾患の基礎研究/サイトカイン・ケモカイン リウマチ滑膜の低ミトコンドリア生合成は滑膜増殖を亢進させ関節破壊の誘導に寄与する

  上羽 岳志, 酒井 良忠, 前田 俊恒, 西本 華子, 林 申也, 橋本 慎吾, 福田 康治, 三浦 靖史, 黒坂 昌弘, 柱本 照, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2017, 日本リウマチ学会総会・学術集会プログラム・抄録集, 61回, 589 - 589, Japanese

  [Refereed]


• FasLによるリウマチ滑膜線維芽細胞における遺伝子発現誘導の検討

  前田 俊恒, 三浦 靖史, 福田 康治, 林 申也, 黒田 良祐

  (一社)日本リウマチ学会, Mar. 2017, 日本リウマチ学会総会・学術集会プログラム・抄録集, 61回, 719 - 719, Japanese

  [Refereed]


• 硬膜内髄外腫瘍に起因する水頭症により意識障害を呈した2例

  佐々木 優, 由留部 崇, 前野 耕一郎, 角谷 賢一朗, 黒田 良祐, 西田 康太郎

  (一社)中部日本整形外科災害外科学会, Mar. 2017, 中部日本整形外科災害外科学会雑誌, 60(2) (2), 383 - 384, Japanese

  [Refereed]


• Anterior Cruciate Ligament-Derived Stem Cells Transduced with BMP2 Accelerate Graft-Bone Integration after ACL Reconstruction

  Yohei Kawakami, Koji Takayama, Tomoyuki Matsumoto, Ying Tang, Bing Wang, Yutaka Mifune, James H. Cummins, Ryan J. Warth, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H. Fu, Johnny Huard

  SAGE Publications Inc., Mar. 2017, American Journal of Sports Medicine, 45(3) (3), 584 - 597, English

  [Refereed]

  Scientific journal


• 脊椎転移に対する集学的治療の予後改善効果

  Kakutani Kenichiro, Sakai Yoshitada, 前野耕一郎, 高田徹, 寺嶋良樹, 伊藤雅明, 垣内裕司, 武岡由樹, 江島泰生, Hara Hitomi, Okada Takuya, Sakashita Akihiro, Sasaki Ryohei, 秋末敏宏, Kuroda Ryosuke, 西田康太郎

  (一社)日本脊椎脊髄病学会, Feb. 2017, Journal of Spine Research, 8(2) (2), 139 - 146, Japanese

  [Refereed]

  Scientific journal


• Rotator cuff repair using cell sheets derived from human rotator cuff in a rat model

  Yoshifumi Harada, Yutaka Mifune, Atsuyuki Inui, Ryosuke Sakata, Tomoyuki Muto, Fumiaki Takase, Yasuhiro Ueda, Takeshi Kataoka, Takeshi Kokubu, Ryosuke Kuroda, Masahiro Kurosaka

  Feb. 2017, JOURNAL OF ORTHOPAEDIC RESEARCH, 35(2) (2), 289 - 296, English

  [Refereed]

  Scientific journal


• Evaluation of quadriceps strength recovery stratified preoperative quadriceps strength after anterior cruciate ligament reconstruction with hamstrings autograft in male and female.

  Ueda Yuya, Matsushita Takehiko, Takiguchi Kohei, Shibata Yohei, Ono Kumiko, Ono Rei, Araki Daisuke, Kanzaki Noriyuki, Sakai Yoshitada, Kuroda Ryosuke

  【Purpose】

  Although some studies have reported preoperative quadriceps strength associates postoperative quadriceps strength recovery after anterior cruciate ligament（ACL）reconstruction with hamstrings tendon autograft, there are no studies investigating about postoperative quadriceps strength recovery after grouping by preoperative quadriceps strength. The purpose of this study was to assess postoperative quadriceps strength recovery after ACL reconstruction with hamstrings tendon autograft in male and female, stratified preoperative quadriceps strength.

  【Methods】

  Isokinetic quadriceps strength at 60°/s was measured at preoperatively, 3, 6, and 12 months after surgery in 393 patients（194 males and 199 females）underwent ACL reconstruction with hamstrings tendon autograft. Quadriceps strength index（QSI）was calculated by normalizing the peak toque of the involved leg with the uninvolved leg. The subjects were stratified by sex and preoperative QSI（＜60% group, 60-80% group, ≥80% group）. A three（group）× three（time）analysis of variance with repeated-measures and Tukey post hoc tests were performed to evaluate postoperative QSI recover after surgery in male and female.

  【Results】

  Interaction effect was not observed（male：p=0.29, female：p=0.28）but main effect of time（male：p＜0.0001, female：p＜0.0001）and preoperative QSI group（male：p＜0.0001, female：p＜0.0001）were observed. In both male and female, 60-80% group and ≥80% group were significantly higher QSI than＜60% group at 3 and 6 months after surgery. In addition, ≥80% group was significantly higher QSI than ＜60% group at 12 months after surgery in male and female.

  【Discussion】

  This study shows postoperative QSI recovery data in each group stratified by sex and preoperative QSI and suggests that preoperative QSI affects postoperative QSI after ACL reconstruction with hamstrings tendon autograft.

  公益社団法人 日本理学療法士協会, 2017, 理学療法学Supplement, 2016, 1195 - 1195, Japanese


• Dislocation of peroneal tendon caused by peroneus quartus muscle, a case report

  YAMASAKI Yoshinori

  THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, 2017, The Central Japan Journal of Orthopaedic Surgery & Traumatology, 60(4) (4), 797 - 798, Japanese


• 内側膝蓋大腿靱帯再建術後の主観的評価に影響を及ぼす因子の検討

  柴田 洋平, 松下 雄彦, 荒木 大輔, 木田 晃弘, 瀧口 耕平, 上田 雄也, 小野 くみ子, 神崎 至幸, 酒井 良忠, 黒田 良祐

  スポーツ傷害フォーラム, Jan. 2017, スポーツ傷害, 22, 16 - 16, Japanese


• Thrombin-antithrombin III complex tests: A useful screening tool for postoperative venous thromboembolism in lower limb and pelvic fractures

  Sang Yang Lee, Takahiro Niikura, Takashi Iwakura, Yoshitada Sakai, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2017, JOURNAL OF ORTHOPAEDIC SURGERY, 25(1) (1), English

  [Refereed]

  Scientific journal


• The contribution of intraoperative medial compartment stability to post-operative knee flexion angle in unicompartmental knee arthroplasty

  Tokio Matsuzaki, Tomoyuki Matsumoto, Hirotsugu Muratsu, Kazunari Ishida, Koji Takayama, Kanto Nagai, Naoki Nakano, Kyohei Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2017, Knee Surgery, Sports Traumatology, Arthroscopy, 25(1) (1), 272 - 276, English

  [Refereed]

  Scientific journal


• Two cases of late medial instability of the knee due to hip disease after total knee arthroplasty

  Masanori Tsubosaka, Tomoyuki Matsumoto, Koji Takayama, Naoki Nakano, Ryosuke Kuroda

  Elsevier Ltd, 2017, International Journal of Surgery Case Reports, 37, 200 - 204, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Therapeutic Potential of Endothelial Progenitor Cells in the Field of Orthopaedics

  Yohei Kawakami, Tomoyuki Matsumoto, Yutaka Mifune, Tomoaki Fukui, Kunj G. Patel, Garth N. Walker, Masahiro Kurosaka, Ryosuke Kuroda

  2017, CURRENT STEM CELL RESEARCH & THERAPY, 12(1) (1), 3 - 13, English

  [Refereed]

  Scientific journal


• Mobile Bearing Total Knee Arthroplasty for Valgus Knee Osteoarthritis with Permanent Patellar Dislocation: A Case Report and Review of the Literature

  KamadaK, Matsumoto Tomoyuki, TakayamaK, ArakiD, Hashimoto Shingo, Hayashi Shinya, Matsushita Takehiko, Kuroda Ryosuke

  Permanent patellar dislocation with tibiofemoral joint osteoarthritis is a relatively rare condition. To treat this condition, total knee arthroplasty with proximal or distal realignment of the extensor mechanism has been reported. We report a challenging case of an 80-year-old woman diagnosed with permanent patellar dislocation with tibiofemoral joint osteoarthritis treated by a mobile bearing total knee arthroplasty utilizing navigation system. Lateral retinaculum release was performed to improve patellar tracking; other proximal or distal realignment of the extensor mechanism was not necessary. Postoperative radiographs show stable patellar tracking and recurrent patellar dislocation was not observed. This clinical case indicates that the implant's precise alignment and rotation during total knee arthroplasty could settle anatomical abnormalities of permanent patellar dislocation and the mobile bearing insert could contribute to stabilizing patellar tracking.

  2017, Case Rep Orthop, 2017, 1230412 - 1230412, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Thrombin-antithrombin III complex tests: A useful screening tool for postoperative venous thromboembolism in lower limb and pelvic fractures

  Sang Yang Lee, Takahiro Niikura, Takashi Iwakura, Yoshitada Sakai, Ryosuke Kuroda, Masahiro Kurosaka

  SAGE Publications Ltd, Jan. 2017, Journal of Orthopaedic Surgery, 25(1) (1), 170840616684501, English

  [Refereed]

  Scientific journal


• High tibial osteotomy combined with cancellous bone graft and osteochondral autograft transplantation in a patient with massive osteochondral defects in the medial femoral condyle: A case report and literature review

  Takehiko Matsushita, Shu Watanabe, Daisuke Araki, Tomoyuki Matsumoto, Koji Takayama, Masahiro Kurosaka, Ryosuke Kuroda

  SAGE Publications Ltd, Jan. 2017, Journal of Orthopaedic Surgery, 25(1) (1), 2309499016685016, English

  [Refereed]

  Scientific journal


• A new quantitative radiographic measurement of patella for patellar instability using the lateral plain radiograph: ‘patellar width ratio’

  Ryosuke Kuroda, Kanto Nagai, Takehiko Matsushita, Daisuke Araki, Tomoyuki Matsumoto, Koji Takayama, Masahiro Kurosaka

  Jan. 2017, Knee Surgery, Sports Traumatology, Arthroscopy, 25(1) (1), 123 - 128, English

  [Refereed]

  Scientific journal


• AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway

  Masayuki Morishita, Teruya Kawamoto, Hitomi Hara, Yasuo Onishi, Takeshi Ueha, Masaya Minoda, Etsuko Katayama, Toshiyuki Takemori, Naomasa Fukase, Masahiro Kurosaka, Ryosuke Kuroda, Toshihiro Akisue

  Jan. 2017, INTERNATIONAL JOURNAL OF ONCOLOGY, 50(1) (1), 23 - 30, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Lumbar spondylolysis: A report of four cases from two generations of a family

  Takashi Yurube, Kenichiro Kakutani, Koji Okamoto, Michihiko Manabe, Koichiro Maeno, Masaho Yoshikawa, Norihide Sha, Ryosuke Kuroda, Kotaro Nishida

  2017, Journal of Orthopaedic Surgery, 25(2) (2), 2309499017713917, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• ハイドロゲルを使用した経皮的炭酸ガス投与はラット末梢神経損傷を改善させる

  乾 淳幸, 西本 華子, 美舩 泰, 国分 毅, 酒井 良忠, 黒田 良祐

  日本末梢神経学会, Dec. 2016, 末梢神経, 27(2) (2), 276 - 276, Japanese


• 膝前十字靱帯再建術後不安定性再発及び関節軟骨損傷を来し、前十字靱帯再再建術及び自家培養軟骨細胞移植術を施行した1例

  荒木 大輔, 松下 雄彦, 神崎 至幸, 黒田 良祐

  (一社)日本移植学会, Dec. 2016, 移植, 51(6) (6), 526 - 526, Japanese


• Subjective evaluation before and after total knee arthroplasty using the 2011 Knee Society Score

  Yuichi Kuroda, Tomoyuki Matsumoto, Koji Takayama, Kazunari Ishida, Ryosuke Kuroda, Masahiro Kurosaka

  Dec. 2016, KNEE, 23(6) (6), 964 - 967, English

  [Refereed]

  Scientific journal


• 前下脛腓靱帯結合部に及ぶ骨軟骨腫の治療経験

  安喰健祐, Kanzaki Noriyuki, Kuroda Ryosuke, 黒坂昌弘

  Nov. 2016, 中部日本整形外科災害外科学会雑誌, 59(6号) (6号), 1179 - 1180, Japanese

  [Refereed]

  Scientific journal


• 恒久性膝蓋骨脱臼を伴った変形性膝関節症に対して人工膝関節置換術を施行した1例

  鎌田紘平, 松本知之, 高山孝治, 荒木大輔, Matsushita Takehiko, Kuroda Ryosuke

  (一社)中部日本整形外科災害外科学会, Nov. 2016, 中部日本整形外科災害外科学会雑誌, 59(6号) (6号), 1165 - 1166, Japanese

  [Refereed]

  Scientific journal


• Expression of adiponectin receptors in human and rat intervertebral disc cells and changes in receptor expression during disc degeneration using a rat tail temporary static compression model

  Yoshiki Terashima, Kenichiro Kakutani, Takashi Yurube, Toru Takada, Koichiro Maeno, Hiroaki Hirata, Shingo Miyazaki, Masaaki Ito, Yuji Kakiuchi, Yoshiki Takeoka, Ryosuke Kuroda, Kotaro Nishida

  Nov. 2016, JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, 11(1) (1), 147, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 膝前十字靱帯再建術後の下肢における筋肉の量および質と膝伸展筋力およびパフォーマンスとの関連

  上田 雄也, 松下 雄彦, 荒木 大輔, 瀧口 耕平, 柴田 洋平, 小野 くみ子, 小野 玲, 松本 知之, 高山 孝治, 酒井 良忠, 黒坂 昌弘, 黒田 良祐

  (公社)日本理学療法士協会, Oct. 2016, 理学療法学, 43(Suppl.2) (Suppl.2), P - 3, Japanese

  [Refereed]


• Effects of parathyroid hormone 1-34 on osteogenic and chondrogenic differentiation of human fracture haematoma-derived cells in vitro

  Yoshihiro Dogaki, Sang Yang Lee, Takahiro Niikura, Takaaki Koga, Etsuko Okumachi, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  John Wiley and Sons Ltd, Oct. 2016, Journal of Tissue Engineering and Regenerative Medicine, 10(10) (10), E365 - E371, English

  [Refereed]

  Scientific journal


• 膝前十字靱帯再建術前後での膝伸展筋力の変化 術前膝伸展筋力層別化による検討

  上田雄也, 松下雄彦, 滝口耕平, 瀧口耕平, 柴田洋平, 荒木大輔, Kanzaki Noriyuki, Sakai Yoshitada, 黒坂昌弘, Kuroda Ryosuke

  (一社)日本臨床スポーツ医学会, Oct. 2016, 日本臨床スポーツ医学会誌, 24(4号) (4号), S199 - S199, Japanese

  [Refereed]

  Research society


• 足関節外側靱帯損傷に対する鏡視下Brostrom法の治療成績

  Kanzaki Noriyuki, 松下雄彦, 荒木大輔, 西田京平, 茨木一行, 宮地伸晃, Kuroda Ryosuke

  (一社)日本臨床スポーツ医学会, Oct. 2016, 日本臨床スポーツ医学会誌, 24(4号) (4号), S318 - S318, Japanese

  [Refereed]

  Research society


• 足関節外側靱帯損傷に対する鏡視下Brostrom法の治療成績

  Kanzaki Noriyuki, 茨木一行, 杜多昭彦, 高倉義幸, 高倉義典, Kuroda Ryosuke

  Oct. 2016, 日本足の外科学会雑誌, 37(2号) (2号), S162, Japanese

  [Refereed]

  Research society


• 若年者における足関節外反を伴う内果疲労骨折の1例

  茨木一行, Kanzaki Noriyuki, 松下雄彦, 荒木大輔, 西田京平, 宮地伸晃, Kuroda Ryosuke

  (一社)日本臨床スポーツ医学会, Oct. 2016, 日本臨床スポーツ医学会誌, 24(4号) (4号), S316 - S316, Japanese

  [Refereed]

  Research society


• 外傷性後脛骨筋腱断裂に対する治療経験

  茨木一行, Kanzaki Noriyuki, 竹内一裕, 羽田勝彦, 木原伸介, Kuroda Ryosuke

  Oct. 2016, 日本足の外科学会雑誌, 37(2号) (2号), S285, Japanese

  [Refereed]

  Research society


• SAFE-Qを用いた当院における人工足関節置換術術後の臨床評価

  茨木一行, Kanzaki Noriyuki, 竹内一裕, 羽田勝彦, 木原伸介, Kuroda Ryosuke

  Oct. 2016, 日本足の外科学会雑誌, 37(2号) (2号), S223, Japanese

  Research society


• Arthroscopic Rotator Cuff Repair With Graft Augmentation of Fascia Lata for Large and Massive Tears

  Kokubu Takeshi, Mifune Yutaka, InuiA, Kuroda Ryosuke

  Excellent clinical results of arthroscopic repair of rotator cuff tears have been reported. However, retears after surgical repair of large and massive rotator cuff tears are one of the most common complications. We present single-row repair with graft augmentation of the fascia lata for large and massive rotator cuff tears to reduce tension at the tendon-bone repair site, and this technique may prevent retears of the repaired rotator cuff. A candidate for this technique is a patient who has a large or massive rotator cuff tear in which the torn edge cannot reach the footprint after mobilization of the torn rotator cuff. This technique could provide an excellent option for irreparable large and massive rotator cuff tears.

  Oct. 2016, Arthrosc Tech, 5(6) (6), e1235 - e1238, English, International magazine

  [Refereed]

  Scientific journal


• リバース型人工肩関節置換術における関節窩側スクリュー挿入角度の検討

  国分 毅, 美舩 泰, 乾 淳幸, 高瀬 史明, 黒澤 尭, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 252 - 252, Japanese


• 腱板断裂性肩関節症に合併したacromioclavicular joint cystの1例

  黒澤 尭, 国分 毅, 美舩 泰, 乾 淳幸, 植田 安洋, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 310 - 310, Japanese


• 老化促進モデルマウスにおける肩腱板付着部(enthesis)の検討

  美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 片岡 武史, 黒沢 尭, 黒田 良祐, 国分 毅

  (一社)日本肩関節学会, Sep. 2016, 日本肩関節学会抄録集, 43回, 292 - 292, Japanese


• 骨吸収マーカーTRACP-5bとHip Structural Analysisにおける断面係数は相関するのか? TRACP-5bの病態把握における意義について

  西本 華子, 乾 淳幸, 笠原 孝一, 酒井 良忠, 黒田 良祐, 鷲見 正敏, 楊 鴻生

  (一社)日本骨粗鬆症学会, Sep. 2016, 日本骨粗鬆症学会雑誌, 2(Suppl.1) (Suppl.1), 210 - 210, Japanese


• 老人性骨粗鬆症モデルマウスにおける肩腱板付着部(enthesis)の検討

  美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 片岡 武史, 黒澤 尭, 黒田 良祐, 国分 毅

  (一社)日本骨粗鬆症学会, Sep. 2016, 日本骨粗鬆症学会雑誌, 2(Suppl.1) (Suppl.1), 264 - 264, Japanese


• 半月板縫合術 適応拡大の功罪 半月板縫合術後の長期成績・再断裂

  松下 雄彦, 田中 聡一, 荒木 大輔, 松本 知之, 高山 孝治, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 86 - 86, Japanese


• 難治性習慣性膝蓋骨脱臼に対し大腿骨遠位内反骨切り術にて良好な結果を得た1例

  立花 章太郎, 松下 雄彦, 荒木 大輔, 高山 孝治, 松本 知之, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 133 - 133, Japanese


• Real-time 3D visualization and navigation using fiber-based endoscopic system for arthroscopic surgery

  Zhongjie Long, Kouki Nagamune, Ryosuke Kuroda, Masahiro Kurosaka

  Fuji Technology Press, Sep. 2016, Journal of Advanced Computational Intelligence and Intelligent Informatics, 20(5) (5), 735 - 742, English

  [Refereed]

  Scientific journal


• 変形性足関節症の病期は人工足関節置換術後の成績に影響があるか?

  Kanzaki Noriyuki, 高倉義典, 高倉義幸, 杜多昭彦, 竹内一裕, Kuroda Ryosuke, 黒坂昌弘

  Sep. 2016, 日本足の外科学会雑誌, 37(1号) (1号), 61 - 63, Japanese

  [Refereed]

  Scientific journal


• 難治性の皮膚潰瘍を伴う麻痺性内反尖足変形に対してTaylor Spatial Frame(TSF)を用いて治療した一例

  竹内一裕, Kanzaki Noriyuki, 羽田勝彦, 木原伸介, 鎮西伸顕, Kuroda Ryosuke, 黒坂昌弘

  Sep. 2016, 日本足の外科学会雑誌, 37(1号) (1号), 363 - 366, Japanese

  [Refereed]

  Scientific journal


• 軟骨損傷を伴った習慣性膝蓋骨脱臼に対して脛骨粗面前内方近位移行および内側膝蓋大腿靱帯再建術にて良好な成績を得た1例

  渡邉秀, 松下雄彦, 荒木大輔, 松本知之, 高山孝治, 鎌田紘平, Kanzaki Noriyuki, Kuroda Ryosuke

  (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(5号) (5号), 1085 - 1086, Japanese

  [Refereed]

  Research society


• 脊椎椎間板髄核におけるオートファジーの重要性とその誘導による椎間板変性予防の可能性

  由留部崇, 伊藤雅明, Kakutani Kenichiro, Maeno Koichiro, Kuroda Ryosuke, Nishida Kotaro

  (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 245 - 245, Japanese

  [Refereed]

  Research society


• 人工股関節置換術後のステム周囲の骨密度は術後の活動性と相関する

  Kanzaki Noriyuki, Hayashi Shinya, 羽田勝彦, 橋本慎吾, 木原伸介, 竹内一裕, 茨木一行, Kuroda Ryosuke

  Sep. 2016, 日本骨粗鬆症学会雑誌, 2(Suppl.1) (Suppl.1), 222, Japanese

  Research society


• 骨欠損に対するMasquelet法 Masquelet法におけるRIAの有用性と問題点

  Niikura Takahiro, 李相亮, 岩倉崇, Kuroda Ryosuke

  Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 79, Japanese

  [Refereed][Invited]

  Research society


• 硬膜内髄外腫瘍に起因する水頭症により意識障害を呈した2例

  佐々木優, 由留部崇, Maeno Koichiro, Kakutani Kenichiro, Kuroda Ryosuke, Nishida Kotaro

  (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 327 - 327, Japanese

  [Refereed]

  Research society


• ゾレドロン酸・デノスマブを投与された前立腺癌患者における両側非定型大腿骨転子下骨折の1例

  十倉健男, 李相亮, 岩倉崇, Niikura Takahiro, Kuroda Ryosuke

  Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 271, Japanese

  [Refereed]

  Research society


• Validation of Quantitative Measures of Rotatory Knee Laxity

  Volker Musahl, Chad Griffith, James J. Irrgang, Yuichi Hoshino, Ryosuke Kuroda, Nicola Lopomo, Stefano Zaffagnini, Kristian Samuelsson, Jon Karlsson

  Sep. 2016, AMERICAN JOURNAL OF SPORTS MEDICINE, 44(9) (9), 2393 - 2398, English

  [Refereed]

  Scientific journal


• Summit stem使用症例の中期成績

  熊谷直利, Hayashi Shinya, 橋本慎吾, Kanzaki Noriyuki, Kuroda Ryosuke

  Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 237, Japanese

  Research society


• DDHと側彎症における小児検診 大都市における側彎症検診の現状と課題

  Kakutani Kenichiro, 宇野耕吉, 由留部崇, Maeno Koichiro, Nishida Kotaro, Kuroda Ryosuke

  (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 81 - 81, Japanese

  [Refereed]

  Research society


• Correlation between hip function and knee kinematics evaluated by three-dimensional motion analysis during lateral and medial side-hopping

  Hiromitsu Itoh, Kohei Takiguchi, Yohei Shibata, Satoshi Okubo, Shinichi Yoshiya, Ryosuke Kuroda

  Society of Physical Therapy Science (Rigaku Ryoho Kagakugakkai), Sep. 2016, Journal of Physical Therapy Science, 28(9) (9), 2461 - 2467, English

  [Refereed]

  Scientific journal


• ウサギ腱板断裂修復モデルに対する自家大腿筋膜補強術の検討

  片岡 武史, 国分 毅, 無藤 智之, 美舩 泰, 乾 淳幸, 高瀬 史明, 植田 安洋, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1433 - S1433, Japanese


• 老化がアキレス腱縫合術後の腱に及ぼす影響の検討

  植田 安洋, 乾 淳幸, 美舩 泰, 国分 毅, 原田 義文, 高瀬 史明, 片岡 武史, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1791 - S1791, Japanese


• エストロゲン欠乏がラット腱細胞に及ぼす影響の検討

  乾 淳幸, 西本 華子, 美舩 泰, 高瀬 史明, 植田 安洋, 片岡 武史, 酒井 良忠, 国分 毅, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1791 - S1791, Japanese


• TKAの機能向上をめざしたバイオメカニクス研究 テンサーによる評価と術後成績

  松本 知之, 高山 孝治, 村津 裕嗣, 石田 一成, 荒木 大輔, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1452 - S1452, Japanese


• 新規OA治療の標的分子探索 SIRT1による軟骨変性と変形性関節症の抑制

  松下 雄彦, 西田 京平, 松崎 時夫, 高山 孝治, 松本 知之, 荒木 大輔, 黒坂 昌弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1457 - S1457, Japanese


• Navigation-based tibial rotation at 90° of flexion is associated with better range of motion in navigated total knee arthroplasty

  Kazunari Ishida, Nao Shibanuma, Tomoyuki Matsumoto, Hiroshi Sasaki, Koji Takayama, Yuji Hiroshima, Ryosuke Kuroda, Masahiro Kurosaka

  Springer Verlag, Aug. 2016, Knee Surgery, Sports Traumatology, Arthroscopy, 24(8) (8), 2447 - 2452, English

  [Refereed]

  Scientific journal


• 糖尿病ラットの骨折治癒過程におけるSDF-1およびCXCR4発現の検討

  新倉路生, 李相亮, Niikura Takahiro, 岩倉崇, 高原俊介, Kuroda Ryosuke, 黒坂昌弘

  Aug. 2016, 日本整形外科学会雑誌, 90(8号) (8号), S1704, Japanese

  [Refereed]

  Research society


• 炭酸ガス経皮吸収の継続期間がラット骨折治癒に与える影響の検討

  岩倉崇, Niikura Takahiro, 李相亮, 高原俊介, 新倉路生, Kuroda Ryosuke, 黒坂昌弘

  Aug. 2016, 日本整形外科学会雑誌, 90(8号) (8号), S1707, Japanese

  [Refereed]

  Research society


• 足関節外側靱帯損傷に対する治療戦略 新鮮足関節外側靱帯損傷に対する治療の第1選択は保存療法である

  Kanzaki Noriyuki, 林申也, 橋本慎吾, 茨木一行, Kuroda Ryosuke

  (一社)日本整形外科スポーツ医学会, Aug. 2016, 日本整形外科スポーツ医学会雑誌, 36(4号) (4号), 329 - 329, Japanese

  Research society


• 偽関節組織は不要な組織か ヒト偽関節組織の生物学的特性の評価

  高原俊介, Niikura Takahiro, 李相亮, 岩倉崇, 新倉路生, 黒岩祐, Kuroda Ryosuke, 黒坂昌弘

  Aug. 2016, 日本整形外科学会雑誌, 90(8号) (8号), S1572, Japanese

  [Refereed]

  Research society


• リン酸カルシウムセメントを担体とした抗菌薬局所デリバリー セファゾリン・ゲンタマイシンの溶出能評価

  高原俊介, Niikura Takahiro, 李相亮, 岩倉崇, 新倉路生, 黒岩祐, Kuroda Ryosuke, 黒坂昌弘

  Aug. 2016, 日本整形外科学会雑誌, 90(8号) (8号), S1708, Japanese

  [Refereed]

  Research society


• ミトコンドリア生合成亢進がリウマチ滑膜の細胞増殖と関節破壊に与える影響

  上羽岳志, Sakai Yoshitada, 前田俊恒, 森下雅之, Hayashi Shinya, 西本華子, 井上美帆, 原田理沙, 福田康治, 三浦靖史, Kuroda Ryosuke, 黒坂昌弘

  (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1421 - S1421, Japanese

  [Refereed]

  Research society


• エイコサペンタエン酸は酸化ストレス依存性の軟骨細胞の変性、アポトーシスを抑制する

  木原伸介, Hayashi Shinya, 明石祐典, 永田純平, 竹内一裕, 羽田勝彦, 橋本慎吾, Kanzaki Noriyuki, Kuroda Ryosuke, 田畑泰彦, 黒坂昌弘

  Aug. 2016, 日本整形外科学会雑誌, 90(8号) (8号), S1470, Japanese

  [Refereed]

  Research society


• Parathyroid hormone(1-34)間欠投与はラット難治性骨折モデルにおける骨癒合を促進させる

  黒岩祐, 李相亮, 脇貴洋, Niikura Takahiro, 岩倉崇, 高原俊介, 新倉路生, Kuroda Ryosuke, 黒坂昌弘

  Aug. 2016, 日本整形外科学会雑誌, 90(8号) (8号), S1704, Japanese

  [Refereed]

  Research society


• Open-wedge high tibial osteotomyにおけるナビゲーションシステムの有用性の検討

  桐月 伸輔, 松下 雄彦, 荒木 大輔, 岡 真也, 松本 知之, 高山 孝治, 宮地 伸晃, 黒坂 昌弘, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 189 - 189, Japanese


• 外反型変形性膝関節症に対する大腿骨遠位内反骨切り術の術後成績

  井口 貴雄, 松下 雄彦, 荒木 大輔, 松本 知之, 高山 孝治, 西田 京平, 桐月 伸輔, 田中 聡一, 黒坂 昌弘, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 204 - 204, Japanese


• 単顆型人工膝関節置換術の手術手技 UKAにおける軟部組織評価

  高山 孝治, 松本 知之, 村津 裕嗣, 石田 一成, 柴沼 均, 荒木 大輔, 松下 雄彦, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 324 - 324, Japanese


• 前十字靱帯不全膝における膝最大伸展位での脛骨前方偏位の検討

  西田 京平, 荒木 大輔, 松下 雄彦, 井口 貴雄, 桐月 伸輔, 田中 聡一, 高山 孝治, 松本 知之, 黒坂 昌弘, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 369 - 369, Japanese


• 膝前十字靱帯再建術前後における膝最大伸展位での脛骨前方偏位の検討

  荒木 大輔, 松下 雄彦, 西田 京平, 桐月 伸輔, 田中 聡一, 井口 貴雄, 松本 知之, 高山 孝治, 長宗 高樹, 黒坂 昌弘, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 369 - 369, Japanese


• 若年患者における前十字靱帯再建術の術後成績

  張 樹蓉, 松下 雄彦, 荒木 大輔, 松本 知之, 高山 孝治, 黒田 雄一, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 378 - 378, Japanese


• 膝関節の再生医療 軟骨変性抑制による膝関節再生

  松下 雄彦, 黒田 良祐, 高山 孝治, 西田 京平, 田中 聡一, 松本 知之, 荒木 大輔, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 390 - 390, Japanese


• 内側膝蓋大腿靱帯再建術におけるX線透視下に決定した大腿骨骨孔位置での再建靱帯の長さ変化の検討

  松下 雄彦, 黒田 良祐, 荒木 大輔, 星野 祐一, 佐々木 謙, 岡 真也, 松本 知之, 高山 孝治, 黒田 雄一, 宮地 伸晃, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 411 - 411, Japanese


• 外側半月板手術後のスポーツ復帰と予後 外側半月板手術後のスポーツ復帰

  黒田 良祐, 松下 雄彦, 田中 聡一, 荒木 大輔, 松本 知之

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 515 - 515, Japanese


• Reconstruction of the Midfoot Using a Free Vascularized Fibular Graft After En Bloc Excision for Giant Cell Tumor of the Tarsal Bones: A Case Report

  Hitomi Hara, Teruya Kawamoto, Yasuo Onishi, Hiroyuki Fujioka, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka, Toshihiro Akisue

  Jul. 2016, Journal of Foot and Ankle Surgery, 55(4) (4), 838 - 841, English

  [Refereed]

  Scientific journal


• Reconstruction of the Midfoot Using a Free Vascularized Fibular Graft After En Bloc Excision for Giant Cell Tumor of the Tarsal Bones: A Case Report

  Hitomi Hara, Teruya Kawamoto, Yasuo Onishi, Hiroyuki Fujioka, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka, Toshihiro Akisue

  Jul. 2016, JOURNAL OF FOOT & ANKLE SURGERY, 55(4) (4), 838 - 841, English

  [Refereed]

  Scientific journal


• 非定型大腿骨骨折 私ならこうする 新しい疾患概念? インプラント周囲の非定型大腿骨骨折

  Niikura Takahiro, 李相亮, 岩倉崇, Kuroda Ryosuke, 黒坂昌弘

  Jul. 2016, 骨折, 38(Suppl.) (Suppl.), S34, Japanese

  [Invited]

  Research society


• 当院におけるMorel-Lavallee lesionの検討

  高原俊介, Niikura Takahiro, 李相亮, 岩倉崇, Kuroda Ryosuke, 黒坂昌弘

  Jul. 2016, 骨折, 38(Suppl.) (Suppl.), S165, Japanese

  [Refereed]

  Research society


• 当院で経験した非定型大腿骨骨折症例の検討

  李相亮, Niikura Takahiro, 岩倉崇, Kuroda Ryosuke, 黒坂昌弘

  Jul. 2016, 骨折, 38(Suppl.) (Suppl.), S149, Japanese

  [Refereed]

  Research society


• 炭酸ガス経皮吸収がラットの前脛骨筋筋損傷モデルへ及ぼす効果の検討

  赤羽志保, Sakai Yoshitada, 西本華子, Kuroda Ryosuke, 黒坂昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4号) (4号), 291 - 291, Japanese

  [Refereed]

  Research society


• 単純X線学的指標と股関節唇損傷形態との関連性

  橋本慎吾, Kanzaki Noriyuki, 木原伸介, Kuroda Ryosuke, 黒坂昌弘

  Jul. 2016, JOSKAS, 41(4号) (4号), 185, Japanese

  [Refereed]

  Research society


• 大腿骨頭離断性骨軟骨炎に対してRAO、骨軟骨柱移植術を施行したアメリカンフットボール選手の1例

  木原伸介, 橋本慎吾, Kanzaki Noriyuki, 荒木大輔, 松下雄彦, Kuroda Ryosuke, 黒坂昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4号) (4号), 188 - 188, Japanese

  Research society


• 大腿骨近位部骨折を起こした高齢者におけるビタミンD充足度の調査

  Niikura Takahiro, 大江啓介, 岩倉崇, Sakai Yoshitada, 李相亮, 櫻井敦志, Kuroda Ryosuke, 黒坂昌弘

  Jul. 2016, 骨折, 38(Suppl.) (Suppl.), S141, Japanese

  [Refereed]

  Research society


• 髄内釘で治療した下肢長管骨偽関節の治療成績 QOLを中心とした検討

  岩倉崇, Niikura Takahiro, 李相亮, Kuroda Ryosuke, 黒坂昌弘

  Jul. 2016, 骨折, 38(Suppl.) (Suppl.), S214, Japanese

  [Refereed]

  Research society


• 四肢骨格筋量は高齢者QOLに影響を及ぼすのか? 骨格筋指数とEQ-5Dを用いたQOL評価の相関関係

  西本華子, 乾淳幸, 笠原孝一, Sakai Yoshitada, Kuroda Ryosuke, 黒坂昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4号) (4号), 332 - 332, Japanese

  [Refereed]

  Research society


• 骨盤・下肢骨折における静脈血栓塞栓症の術後スクリーニング どのマーカーが有用か?

  李相亮, Niikura Takahiro, 岩倉崇, Kuroda Ryosuke, 黒坂昌弘

  Jul. 2016, 骨折, 38(Suppl.) (Suppl.), S140, Japanese

  [Refereed]

  Research society


• 距骨下関節の軟骨損傷を伴った巨大な三角骨障害に対する治療経験

  Kanzaki Noriyuki, 橋本慎吾, Kuroda Ryosuke, 黒坂昌弘

  Jul. 2016, JOSKAS, 41(4号) (4号), 385, Japanese

  [Refereed]

  Research society


• Local Administration of Simvastatin Stimulates Healing of an Avascular Meniscus in a Rabbit Model of a Meniscal Defect

  Shurong Zhang, Takehiko Matsushita, Ryosuke Kuroda, Kyohei Nishida, Tokio Matsuzaki, Tomoyuki Matsumoto, Koji Takayama, Kanto Nagai, Shinya Oka, Yasuhiko Tabata, Kouki Nagamune, Masahiro Kurosaka

  Jul. 2016, American Journal of Sports Medicine, 44(7) (7), 1735 - 1743, English

  [Refereed]

  Scientific journal


• Biomechanical Function of Anterior Cruciate Ligament Remnants: Quantitative Measurement With a 3-Dimensional Electromagnetic Measurement System

  Kanto Nagai, Daisuke Araki, Takehiko Matsushita, Yuichiro Nishizawa, Yuichi Hoshino, Tomoyuki Matsumoto, Koji Takayama, Naoki Nakano, Kouki Nagamune, Masahiro Kurosaka, Ryosuke Kuroda

  Jul. 2016, Arthroscopy - Journal of Arthroscopic and Related Surgery, 32(7) (7), 1359 - 1366, English

  [Refereed]

  Scientific journal


• Antibiotic-impregnated calcium phosphate cement as part of a comprehensive treatment for patients with established orthopaedic infection

  Takahiro Niikura, Sang Yang Lee, Takashi Iwakura, Yoshitada Sakai, Ryosuke Kuroda, Masahiro Kurosaka

  Jul. 2016, JOURNAL OF ORTHOPAEDIC SCIENCE, 21(4) (4), 539 - 545, English

  [Refereed]

  Scientific journal


• ミトコンドリア生合成の差異が関節リウマチ滑膜細胞に与える影響について

  上羽 岳志, 酒井 良忠, 前田 俊恒, 西本 華子, 井上 美帆, 原田 理沙, 赤羽 志保, 仲山 舞, 小林 慶通, 黒田 良祐, 三浦 靖史, 黒坂 昌弘

  (公社)日本リハビリテーション医学会, Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I410 - I410, Japanese


• 関節リウマチ患者の骨粗鬆症に対する抗RANKL抗体製剤デノスマブの使用経験

  前田俊恒, Hayashi Shinya, 三浦靖史, Sakai Yoshitada, 黒田良祐, 黒坂昌弘

  (公社)日本リハビリテーション医学会, Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I46 - I46, Japanese

  [Refereed]

  Research society


• The influence of posterior tibial slope changes on joint gap and range of motion in unicompartmental knee arthroplasty

  Koji Takayama, Tomoyuki Matsumoto, Hirotsugu Muratsu, Kazunari Ishida, Daisuke Araki, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Elsevier B.V., Jun. 2016, Knee, 23(3) (3), 517 - 522, English

  [Refereed]

  Scientific journal


• The influence of intraoperative soft tissue balance on patellar pressure in posterior-stabilized total knee arthroplasty

  Tomoyuki Matsumoto, Nao Shibanuma, Koji Takayama, Hiroshi Sasaki, Kazunari Ishida, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Elsevier B.V., Jun. 2016, Knee, 23(3) (3), 540 - 544, English

  [Refereed]

  Scientific journal


• 炭酸ガス経皮吸収は大腿骨骨折モデルの筋萎縮を軽減する

  井上美帆, Sakai Yoshitada, 上羽岳志, 大江啓介, Niikura Takahiro, 李相亮, 岩倉崇, 仲山舞, 原田理沙, 赤羽志保, 西本華子, Kuroda Ryosuke, 黒坂昌弘

  (公社)日本リハビリテーション医学会, Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I237 - I237, Japanese

  [Refereed]

  Research society


• 炭酸ガス経皮吸収は、腱炎の治癒を促進する

  原田理沙, Sakai Yoshitada, 上羽岳志, 乾敦幸, 西本華子, 井上美帆, 赤羽志保, Kuroda Ryosuke, 黒坂昌弘

  (公社)日本リハビリテーション医学会, Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I237 - I237, Japanese

  [Refereed]

  Research society


• 神経圧挫モデルでの神経・筋肉機能回復過程における炭酸ガス経皮吸収の効果について

  西本華子, 乾淳幸, 上羽岳志, 仲山舞, 井上美帆, 赤羽志保, 原田理沙, Kuroda Ryosuke, 黒坂昌弘, Sakai Yoshitada

  (公社)日本リハビリテーション医学会, Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I238 - I238, Japanese

  [Refereed]

  Research society


• 骨吸収マーカーTRACP-5bとHip Structural Analysisにおける断面係数の相関関係

  西本華子, 乾淳幸, Kuroda Ryosuke, 黒坂昌弘, Sakai Yoshitada

  (公社)日本リハビリテーション医学会, Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I17 - I17, Japanese

  [Refereed]

  Research society


• 下咽頭癌でサルコペニアをきたしたポリオ後遺症患者にリハビリテーション介入・長下肢装具導入を行った1例

  仲山舞, 原田理沙, 井上美帆, 赤羽志保, 西本華子, 三浦靖史, Kuroda Ryosuke, 黒坂昌弘, Sakai Yoshitada

  (公社)日本リハビリテーション医学会, Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I252 - I252, Japanese

  [Refereed]

  Research society


• 一時的気分尺度とKOKOROスケールを用いた音楽療法がリウマチ患者へ及ぼす影響に関する検討

  三浦靖史, 前田俊恒, Kuroda Ryosuke, 黒坂昌弘

  Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I46, Japanese

  [Refereed]

  Research society


• ポリオ後遺症に対する経皮吸収炭酸ガス治療の有効性および安全性に関する探索的臨床研究

  Sakai Yoshitada, Niikura Takahiro, 秋末敏宏, 原田理沙, 赤羽志保, 井上美帆, 西本華子, 小林慶通, 仲山舞, Kuroda Ryosuke, 黒坂昌弘, 佐浦隆一

  (公社)日本リハビリテーション医学会, Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I253 - I253, Japanese

  [Refereed]

  Research society


• Human pseudoarthrosis tissue contains cells with osteogenic potential

  Shunsuke Takahara, Takahiro Niikura, Sang Yang Lee, Takashi Iwakura, Etsuko Okumachi, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2016, INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 47(6) (6), 1184 - 1190, English

  [Refereed]

  Scientific journal


• Electromagnetic tracking of the pivot-shift.

  Ryosuke Kuroda, Yuichi Hoshino

  The pivot-shift test is an important examination to assess the rotational laxity in the anterior cruciate ligament (ACL) injured and reconstructed knees. Because this examination is related to subjective knee function, we may still see cases that have residual rotational laxity after ACL reconstruction. Quantitative evaluation of the pivot-shift test is preferable to the clinical pivot-shift test but is difficult to attain mainly due to complicated movements of the pivot-shift. The electromagnetic tracking system was developed to evaluate knee kinematics during the pivot-shift, providing information related to 6-degree-of-freedom knee kinematics with a high sampling rate. Through this device, the abnormal movement of the pivot-shift is characterized in two phases: an increased anterior tibial translation and a boosted acceleration of tibial posterior reduction. Since its invention, this system has been utilized to assess rotational laxity for clinical follow-up and research after the ACL reconstruction.

  Jun. 2016, Current reviews in musculoskeletal medicine, 9(2) (2), 164 - 9, English, International magazine

  [Refereed]

  Scientific journal


• 大腿骨骨幹部偽関節に対してロッキングプレートを用いて治療した大理石骨病の1例

  松尾智哉, Niikura Takahiro, 李相亮, 岩倉崇, Kuroda Ryosuke, 黒坂昌弘

  May 2016, 中部日本整形外科災害外科学会雑誌, 59(3号) (3号), 613 - 614, Japanese

  [Refereed]

  Research society


• Stem anteversion affects periprosthetic bone mineral density after total hip arthroplasty

  Shinya Hayashi, Shingo Hashimoto, Noriyuki Kanzaki, Ryosuke Kuroda, Masahiro Kurosaka

  Wichtig Publishing Srl, May 2016, HIP International, 26(3) (3), 260 - 264, English

  [Refereed]

  Scientific journal


• A new predictive indicator by arthrography for future acetabular growth following conservative treatment of developmental dysplasia of the hip

  Shinichi Satsuma, Daisuke Kobayashi, Maki Kinugasa, Yoshiki Takeoka, Ryosuke Kuroda, Masahiro Kurosaka

  Lippincott Williams and Wilkins, Apr. 2016, Journal of Pediatric Orthopaedics Part B, 25(3) (3), 207 - 211, English

  [Refereed]

  Scientific journal


• Medial Gap Techniqueを用いたCR-TKAとPS-TKAの術中軟部組織バランスの比較

  竹森 俊幸, 村津 裕嗣, 松本 知之, 鈴木 孝洋, 壺坂 正徳, 大島 隆司, 圓尾 明弘, 宮 秀俊, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2016, JOSKAS, 41(2) (2), 324 - 325, Japanese


• 前十字靱帯不全膝における膝最大伸展位での脛骨前方偏位の検討

  西田 京平, 荒木 大輔, 松下 雄彦, 井口 貴雄, 桐月 伸輔, 田中 聡一, 高山 孝治, 松本 知之, 黒坂 昌弘, 黒田 良祐

  関西関節鏡・膝研究会, Mar. 2016, 関西関節鏡・膝研究会プログラム・演題抄録, 28回, 16 - 16, Japanese


• 膝離断性骨軟骨炎 若年者膝離断性骨軟骨炎の治療

  松下 雄彦, 黒田 良祐, 荒木 大輔, 桐月 伸輔, 松本 知之, 高山 孝治, 星野 祐一, 黒坂 昌弘

  関西関節鏡・膝研究会, Mar. 2016, 関西関節鏡・膝研究会プログラム・演題抄録, 28回, 37 - 37, Japanese


• 当院におけるスポーツ選手への半月板単独損傷に対する半月板縫合術の治療成績

  田中 聡一, 松下 雄彦, 黒田 良祐, 荒木 大輔, 松本 知之, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2016, 中部日本整形外科災害外科学会雑誌, 59(春季学会) (春季学会), 166 - 166, Japanese


• 単顆型人工膝関節置換術におけるjoint line変化と術後可動域の関係

  高山 孝治, 松本 知之, 村津 裕嗣, 石田 一成, 柴沼 均, 荒木 大輔, 松下 雄彦, 黒田 良祐, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2016, 日本整形外科学会雑誌, 90(2) (2), S111 - S111, Japanese


• ミトコンドリア生合成の亢進はコラーゲン誘導性関節炎(CIA)マウスの関節破壊を抑制する

  上羽 岳志, 酒井 良忠, 前田 俊恒, 林 申也, 橋本 慎吾, 福田 康治, 三浦 靖史, 柱本 照, 黒田 良祐, 黒坂 昌弘

  (一社)日本リウマチ学会, Mar. 2016, 日本リウマチ学会総会・学術集会プログラム・抄録集, 60回, 489 - 489, Japanese

  [Refereed]


• Surgical Management of Irreducible Dislocation of the Peroneus Longus Tendon A Case Report

  Nobuaki Chinzei, Noriyuki Kanzaki, Takaaki Fujishiro, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2016, JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION, 106(2) (2), 121 - 127, English

  [Refereed]

  Scientific journal


• Periarticular multimodal drug injection improves post-operative pain and functional recovery after total knee arthroplasty

  Kazunari Ishida, Nao Shibanuma, Tomoyuki Matsumoto, Katsumasa Tei, Ryosuke Kuroda, Masahiro Kurosaka

  Elsevier, Mar. 2016, Journal of Orthopaedic Science, 21(2) (2), 178 - 183, English

  [Refereed]

  Scientific journal


• 前下脛腓靱帯結合部に及ぶ骨軟骨種の治療経験

  安喰健祐, Kanzaki Noriyuki, Kuroda Ryosuke, 黒坂昌弘

  Mar. 2016, 中部日本整形外科災害外科学会雑誌, 59(春季学会) (春季学会), 300, Japanese

  [Refereed]

  Research society


• 人工足関節置換術前の変形性足関節症の病期は術後の成績に影響があるか

  Kanzaki Noriyuki, 高倉義典, 高倉義幸, 竹内一裕, 羽田勝彦, 木原伸介, 橋本慎吾, 林申也, Kuroda Ryosuke, 黒坂昌弘

  Mar. 2016, 日本整形外科学会雑誌, 90(3号) (3号), S947, Japanese

  [Refereed]

  Research society


• 骨盤・下肢骨折後の静脈血栓塞栓症発生予測因子としての可溶性フィブリン複合体の有用性

  李相亮, Niikura Takahiro, 岩倉崇, 酒井良忠, Kuroda Ryosuke, 黒坂昌弘

  Mar. 2016, 日本整形外科学会雑誌, 90(3号) (3号), S597, Japanese

  [Refereed]

  Research society


• 股関節鏡視下手術の適応と限界 単純X線学的指標から考察する股関節鏡視下手術の適応と限界

  橋本慎吾, Hayashi Shinya, Kanzaki Noriyuki, Kuroda Ryosuke, 黒坂昌弘

  (公社)日本整形外科学会, Mar. 2016, 日本整形外科学会雑誌, 90(3号) (3号), S485 - S486, Japanese

  Research society


• 稀な鎖骨近位端症候性偽関節の1例

  佐々木優, Niikura Takahiro, 李相亮, 岩倉崇, Kuroda Ryosuke, 黒坂昌弘

  Mar. 2016, 中部日本整形外科災害外科学会雑誌, 59(春季学会) (春季学会), 293, Japanese

  [Refereed]

  Research society


• 関節リウマチの手術 下肢 関節リウマチ患者に対する人工股関節全置換術後遅発性感染を引き起こす因子の検討

  Hayashi Shinya, 酒井良忠, 橋本慎吾, Kanzaki Noriyuki, 前田俊恒, 三浦靖史, 上羽岳志, Kuroda Ryosuke, 黒坂昌弘

  Mar. 2016, 日本リウマチ学会総会・学術集会プログラム・抄録集 60回, 373, Japanese

  [Refereed]

  Research society


• Daily activity and initial bone mineral density are associated with periprosthetic bone mineral density after total hip arthroplasty

  Shinya Hayashi, Shingo Hashimoto, Noriyuki Kanzaki, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2016, HIP INTERNATIONAL, 26(2) (2), 169 - 174, English

  [Refereed]

  Scientific journal


• Coronal lower limb alignment in normal knees-A radiographic analysis of 797 normal knee subjects

  Naoki Nakano, Tomoyuki Matsumoto, Masataka Hashimura, Koji Takayama, Kazunari Ishida, Daisuke Araki, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2016, KNEE, 23(2) (2), 209 - 213, English

  [Refereed]

  Scientific journal


• An evaluation method of hardness on quantitative measurement system for lachman test using force sensor

  Shogo Kawaguchi, Kouki Nagamune, Yuichiro Nishizawa, Daisuke Araki, Yuichi Hoshino, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Feb. 2016, Information (Japan), 19(2) (2), 695 - 704

  Scientific journal


• 炭酸ガス経皮吸収の継続期間が骨折治癒に与える影響

  岩倉崇, Niikura Takahiro, 李相亮, Kuroda Ryosuke, 黒坂昌弘

  Feb. 2016, 日本創外固定・骨延長学会雑誌, 27, 137, Japanese

  [Refereed]

  Research society


• Profiling microRNA expression during fracture healing

  Takahiro Waki, Sang Yang Lee, Takahiro Niikura, Takashi Iwakura, Yoshihiro Dogaki, Etsuko Okumachi, Keisuke Oe, Ryosuke Kuroda, Masahiro Kurosaka

  Feb. 2016, BMC MUSCULOSKELETAL DISORDERS, 17(1) (1), 83, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Postoperative Knee Flexion Angle Is Affected by Lateral Laxity in Cruciate-Retaining Total Knee Arthroplasty

  Naoki Nakano, Tomoyuki Matsumoto, Hirotsugu Muratsu, Koji Takayama, Ryosuke Kuroda, Masahiro Kurosaka

  Feb. 2016, JOURNAL OF ARTHROPLASTY, 31(2) (2), 401 - 405, English

  [Refereed]

  Scientific journal


• Development of electromagnetic tracking for the pivot shift

  Ryosuke Kuroda, Yuichi Hoshino, Takehiko Matsushita, Kouki Nagamune, Masahiro Kurosaka

  Springer International Publishing, Jan. 2016, Rotatory Knee Instability: An Evidence Based Approach, 269 - 276, English

  In book


• Arthrodesis of the ankle in the presence of dislocation of ankle and a large defect of the distal tibia: A case report

  TANI Izumi

  THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, 2016, The Central Japan Journal of Orthopaedic Surgery & Traumatology, 59(2) (2), 399 - 400, Japanese


• 膝前十字靭帯再建術後の下肢における筋肉の量および質と膝伸展筋力およびパフォーマンスとの関連

  上田 雄也, 松下 雄彦, 荒木 大輔, 瀧口 耕平, 柴田 洋平, 小野 くみ子, 小野 玲, 松本 知之, 高山 孝治, 酒井 良忠, 黒坂 昌弘, 黒田 良祐

  【はじめに，目的】膝前十字靭帯（以下ACL）再建術後では術側の筋力低下が問題となる。筋力低下の要因として，ACL再建術後では筋量減少など筋肉の量による要因と，神経筋機能低下など筋肉の質による要因のそれぞれが報告されている。しかし両者を包括的に検討した報告は数少ない。またパフォーマンスとそれぞれの関連についての報告はない。機能低下の要因を検討することはリハビリテーションの内容を選択する上で重要である。そこで本研究では，ACL再建術後6ヶ月の術側下肢における筋肉の量および質と，膝伸展筋力およびパフォーマンスの関連について横断的に検討することとした。【方法】2011年7月から2012年9月に当院または当科関連病院にてHamstrings腱を用いたACL単独再建術を施行し，術後6ヶ月に膝関節機能および身体組成を測定し得た連続71名（男性43名，年齢22.8±8.1歳）を対象とした。除外基準は反対側受傷および術側既往歴がある者，膝蓋腱をgraftとして用いた者とした。個人特性は性別，年齢，BMI，受傷前Tegner activity scale（以下TAS）を聴取した。膝関節機能は膝伸展筋力とパフォーマンスとして片脚幅跳び距離を測定した。膝伸展筋力はMYORET RZ-450を用いて等尺90°での最大膝伸展筋力を測定した。片脚幅跳び距離は2回の施行での最大跳躍距離とした。身体組成ではYamato DF860を用い下肢筋肉量を測定した。筋肉の量の評価として，体重あたりの術側下肢筋肉量（以下%筋肉量）を算出した。筋肉の質の評価として，術側の下肢筋量あたりの膝伸展筋力（以下Muscle Quality：MQ）を算出した。統計解析として，術側膝伸展筋力と片脚幅跳び距離それぞれと各項目の関連について単変量解析により検討した。また術側膝伸展筋力と片脚幅跳び距離それぞれを従属変数とし，単変量解析にて有意な関連を示した変数を独立変数とした重回帰分析を実施した。統計はJMP ver12.0を用い，有意水準は5%未満とした。【結果】単変量解析の結果，術側膝伸展筋力は男性で有意に強く（男性205.3±67.9 Nm，女性118.6±29.5 Nm），BMI（r=0.57），TAS（r=0.35），%筋肉量（r=0.41）およびMQ（r=0.80）と有意な関連を認めた。術側片脚幅跳び距離は男性で有意に長く（男性1.47±0.26 m，女性1.09±0.19 m），TAS（r=0.34），%筋肉量（r=0.50）およびMQ（r=0.38）と有意な関連を認めた。重回帰分析の結果，術側膝伸展筋力では性別（β=0.14），BMI（β=0.37），%筋肉量（β=0.29）およびMQ（β=0.61）が独立した因子として抽出された（R²=0.93）。術側片脚幅跳び距離では性別（β=0.42）およびMQ（β=0.69）が独立した因子として抽出された（R²=0.47）。【結論】ACL再建術後6ヶ月では，術側膝伸展筋力には性別，BMIに関わらず筋肉の量および質がそれぞれ独立して関連していた。一方片脚幅跳び距離には筋肉の質は独立して関連していたが，量は独立した関連を認めなかった。本研究より，量のみならず筋肉の質の着目した介入の重要性が示唆される。

  公益社団法人 日本理学療法士協会, 2016, 理学療法学Supplement, 2015, 1297 - 1297, Japanese


• 当院におけるスポーツ選手への半月板単独損傷に対する半月板縫合術の治療成績

  田中 聡一, 松下 雄彦, 黒田 良祐, 荒木 大輔, 松本 知之, 黒坂 昌弘

  スポーツ傷害フォーラム, Jan. 2016, スポーツ傷害, 21, 19 - 19, Japanese


• 高校サッカー選手における鼠径部周囲痛発症前の身体的変化について

  瀧口 耕平, 伊藤 浩充, 藤田 健司, 酒井 良忠, 松下 雄彦, 荒木 大輔, 黒坂 昌弘, 黒田 良祐

  スポーツ傷害フォーラム, Jan. 2016, スポーツ傷害, 21, 23 - 23, Japanese


• Physical examinations and device measurements for ACL deficiency

  Ryosuke Kuroda, Takehiko Matsushita, Daisuke Araki

  Springer Japan, Jan. 2016, ACL Injury and its Treatment, 129 - 137, English

  [Refereed]

  In book


• Strategies to enhance biological tendon-bone healing in anterior cruciate ligament reconstruction

  Tomoyuki Matsumoto, Ryosuke Kuroda

  Springer Japan, Jan. 2016, ACL Injury and its Treatment, 537 - 584, English

  [Refereed]

  In book


• Bone tunnel changes after ACL reconstruction

  Daisuke Araki, Takehiko Matsushita, Ryosuke Kuroda

  Springer Japan, Jan. 2016, ACL Injury and its Treatment, 247 - 266, English

  [Refereed]

  In book


• Avulsion fracture of the ACL

  Takehiko Matsushita, Ryosuke Kuroda

  Springer Japan, Jan. 2016, ACL Injury and its Treatment, 437 - 449, English

  [Refereed]

  In book


• 膝前十字靱帯再建術後の下肢における筋肉の量および質とパフォーマンスとの関連

  上田 雄也, 松下 雄彦, 荒木 大輔, 木田 晃弘, 瀧口 耕平, 柴田 洋平, 小野 くみ子, 小野 玲, 松本 知之, 高山 孝治, 酒井 良忠, 黒坂 昌弘, 黒田 良祐

  スポーツ傷害フォーラム, Jan. 2016, スポーツ傷害, 21, 37 - 37, Japanese

  [Refereed]


• Gait Analysis of Normal Subjects by Using Force Sensor and Six Inertial Sensor with Wireless Module

  Keita Aoike, Kouki Nagamune, Koji Takayama, Ryosuke Kuroda, Masahiro Kurosaka

  2016, 2016 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN, AND CYBERNETICS (SMC), 1257 - 1260, English

  [Refereed]

  International conference proceedings


• Inaccurate rotational component position in image-free navigated unicompartmental knee arthroplasty

  Akihiko Toda, Kazunari Ishida, Tomoyuki Matsumoto, Hiroshi Sasaki, Koji Takayama, Ryosuke Kuroda, Masahiro Kurosaka, Nao Shibanuma

  Elsevier (Singapore) Pte Ltd, Jan. 2016, Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, 3, 19 - 24, English

  [Refereed]

  Scientific journal


• Revision total knee arthroplasty using the modern constrained condylar knee prosthesis

  Naoki Nakano, Tomoyuki Matsumoto, Hirotsugu Muratsu, Kazunari Ishida, Ryosuke Kuroda, Masahiro Kurosaka

  Sociedade Brasileira de Ortopedia e Traumatologia, 2016, Acta Ortopedica Brasileira, 24(6) (6), 304 - 308, English

  [Refereed]

  Scientific journal


• Single- vs. double-bundle ACL reconstruction

  Masahiro Kurosaka, Ryosuke Kuroda, Kanto Nagai

  Jan. 2016, ACL Injury and its Treatment, 291 - 301

  [Refereed]

  In book


• Two Extension Block Kirschner Wires' Technique for Bony Mallet Thumb

  Mifune Yutaka, InuiA, TakaseF, UedaY, ShinoharaI, Kuroda Ryosuke, Kokubu Takeshi

  Mallet fingers with an avulsion fracture of the distal phalanx or rupture of the terminal tendon of the extensor mechanism is known as a common injury, while mallet thumb is very rare. In this paper, the case of a 19-year-old woman with a sprained left thumb sustained while playing basketball is presented. Plain radiographs and computed tomography revealed an avulsion fracture involving more than half of the articular surface at the base of the distal phalanx. Closed reduction and percutaneous fixation were performed using the two extension block Kirschner wires' technique under digital block anesthesia. At 4 months postoperatively, the patient had achieved excellent results according to Crawford's evaluation criteria and had no difficulties in working or playing basketball. Various conservative and operative treatment strategies have been reported for management of mallet thumb. We chose the two extension block Kirschner wires' technique to minimize invasion of the extensor mechanism and nail bed and to stabilize the large fracture fragment.

  2016, Case Rep Orthop, 2016, 8086594 - 8086594, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Navigation-based femorotibial rotation pattern correlated with flexion angle after total knee arthroplasty

  Kazunari Ishida, Nao Shibanuma, Tomoyuki Matsumoto, Hiroshi Sasaki, Koji Takayama, Tokio Matsuzaki, Katsumasa Tei, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2016, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 24(1) (1), 89 - 95, English

  [Refereed]

  Scientific journal


• Inflammation and Degeneration in Cartilage Samples from Patients with Femoroacetabular Impingement

  Nobuaki Chinzei, Shingo Hashimoto, Takaaki Fujishiro, Shinya Hayashi, Noriyuki Kanzaki, Soshi Uchida, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2016, JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 98(2) (2), 135 - 141, English

  [Refereed]

  Scientific journal


• Treatment of ununited femoral neck fractures in young adults using low-intensity pulsed ultrasound: Report of 2 cases

  Sang Yang Lee, Takahiro Niikura, Takashi Iwakura, Ryosuke Kuroda, Masahiro Kurosaka

  Elsevier Ltd, 2016, International Journal of Surgery Case Reports, 21, 59 - 62, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Anterior cruciate ligament remnant tissue harvested within 3-months after injury predicts higher healing potential

  Shurong Zhang, Tomoyuki Matsumoto, Atsuo Uefuji, Takehiko Matsushita, Koji Takayama, Daisuke Araki, Naoki Nakano, Kanto Nagai, Tokio Matsuzaki, Ryosuke Kuroda, Masahiro Kurosaka

  Dec. 2015, BMC Musculoskeletal Disorders, 16(1) (1), 390, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Intermediate-term comparison of posterior cruciate-retaining versus posterior-stabilized total knee arthroplasty using the new knee scoring system

  Yohei Kawakami, Tomoyuki Matsumoto, Koji Takayama, Kazunari Ishida, Naoki Nakano, Takehiko Matsushita, Yuichi Kuroda, Kunji Patel, Ryosuke Kuroda, Masahiro Kurosaka

  Slack Incorporated, Dec. 2015, Orthopedics, 38(12) (12), e1127 - e1132, English

  [Refereed]

  Scientific journal


• エイコサペンタエン酸は軟骨細胞の変性と変形性関節症の進行を抑制する

  木原伸介, Hayashi Shinya, 明石祐典, 永田純平, 竹内裕一, 羽田勝彦, 鎮西伸顕, Kanzaki Noriyuki, 橋本慎吾, Kuroda Ryosuke, 田畑泰彦, Kurosaka Masahiro

  Nov. 2015, 日本バイオマテリアル学会大会予稿集 37回, 333, Japanese

  [Refereed]

  Research society


• p21 deficiency is susceptible to osteoarthritis through STAT3 phosphorylation

  Shinya Hayashi, Takaaki Fujishiro, Shingo Hashimoto, Noriyuki Kanzaki, Nobuaki Chinzei, Shinsuke Kihara, Koji Takayama, Tomoyuki Matsumoto, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda

  Nov. 2015, ARTHRITIS RESEARCH & THERAPY, 17, 314, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Fibular axes are not a reliable landmark for tibial mechanical axes of osteoarthritic knees that underwent total knee arthroplasty

  Yuichi Kuroda, Kazunari Ishida, Tomoyuki Matsumoto, Hiroshi Sasaki, Tokio Matsuzaki, Shinya Oka, Koji Takayama, Katsumasa Tei, Takehiko Matsushita, Nobuhiro Tsumura, Ryosuke Kuroda, Masahiro Kurosaka

  Nov. 2015, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 23(11) (11), 3362 - 3367, English

  [Refereed]

  Scientific journal


• Quantitative comparison of the pivot shift test results before and after anterior cruciate ligament reconstruction by using the three-dimensional electromagnetic measurement system

  Kanto Nagai, Yuichi Hoshino, Yuichiro Nishizawa, Daisuke Araki, Takehiko Matsushita, Tomoyuki Matsumoto, Koji Takayama, Kouki Nagamune, Masahiro Kurosaka, Ryosuke Kuroda

  Oct. 2015, Knee Surgery, Sports Traumatology, Arthroscopy, 23(10) (10), 2876 - 2881, English

  [Refereed]

  Scientific journal


• Limb deformity caused by distal femoral and proximal tibial growth arrest after ACL reconstruction in a child

  Masaki Tomatsuri, Shinichi Yoshiya, Ryosuke Kuroda, Takehiko Matsushita, Masahiro Kurosaka

  Lippincott Williams and Wilkins, Oct. 2015, JBJS Case Connector, 5(4) (4), English

  [Refereed]

  Scientific journal


• 片脚反復横跳びにおける切り返し動作時の膝関節トルクと股関節可動域および股関節周囲筋力との関係

  伊藤 浩充, 瀧口 耕平, 柴田 洋平, 大久保 吏司, 西川 仁史, 川勝 邦浩, 鈴木 順一, 八木 範彦, 吉矢 晋一, 黒田 良祐, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2015, 日本臨床スポーツ医学会誌, 23(4) (4), S282 - S282, Japanese


• Anterior Cruciate Ligament Reconstruction: A 2015 global perspective of the Magellan Society

  Yee Han Dave Lee, Ryosuke Kuroda, Kai Ming Chan

  Elsevier (Singapore) Pte Ltd, Oct. 2015, Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, 2(4) (4), 122 - 128, English

  [Refereed]

  Scientific journal


• 変形性膝関節症治療のガイドラインと新戦略 変形性関節症におけるエピジェネティクスとエピジェネティクス関連因子

  松下雄彦, 松崎時夫, 長井寛斗, 高山孝治, 西田京平, 松本知之, Kuroda Ryosuke, Kurosaka Masahiro

  Oct. 2015, 日本関節病学会誌, 34(3号) (3号), 313, Japanese

  [Refereed][Invited]

  Research society


• 内反型変形性膝関節症に対する人工膝関節全置換術術後下肢アライメントと臨床成績の関係

  西田京平, 松本知之, 高山孝治, 中野直樹, 井口貴雄, 荒木大輔, 松下雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  (一社)日本関節病学会, Oct. 2015, 日本関節病学会誌, 34(3号) (3号), 374 - 374, Japanese

  [Refereed]

  Research society


• 内側膝蓋大腿靱帯再建術後の主観的評価に影響を及ぼす因子の検討

  柴田洋平, 松下雄彦, Kuroda Ryosuke, 荒木大輔, 瀧口耕平, 上田雄也, 松本知之, 高山孝治, Sakai Yoshitada, Kurosaka Masahiro

  (一社)日本臨床スポーツ医学会, Oct. 2015, 日本臨床スポーツ医学会誌, 23(4号) (4号), S181 - S181, Japanese

  [Refereed]

  Research society


• 人工膝関節置換術における新しい挑戦と将来展望 TKAで目指すべきアライメントと手術手技 Kinematic Alignmentも含めて

  松本知之, 西田京平, 高山孝治, 石田一成, 荒木大輔, 松下雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  (一社)日本関節病学会, Oct. 2015, 日本関節病学会誌, 34(3号) (3号), 450 - 450, Japanese

  [Refereed][Invited]

  Research society


• 高校サッカー選手における鼠径部痛及び股関節内転筋群近位部痛の発生要因について

  瀧口耕平, 伊藤浩充, 藤田健司, Sakai Yoshitada, Kurosaka Masahiro, Kuroda Ryosuke

  Oct. 2015, 日本臨床スポーツ医学会誌, 23(4号) (4号), S172, Japanese

  [Refereed]

  Research society


• プロ野球選手に発症した筋皮神経単独損傷の1例

  Kokubu Takeshi, Mifune Yutaka, Kuroda Ryosuke, Kurosaka Masahiro, 山崎哲也

  Oct. 2015, 日本臨床スポーツ医学会誌, 23(4号) (4号), S207, Japanese

  Research society


• Late onset prosthetic hip joint infection in two patients of rheumatoid arthritis treated with etanercept

  Hayashi Shinya, Sakai Yoshitada, Fujishiro Takaaki, Hashimoto Shingo, Kanzaki Noriyuki, Kuroda Ryosuke, Kurosaka Masahiro

  Turkish League Against Rheumatism (TLAR), Sep. 2015, Archives of Rheumatology, 30(2) (2), 168 - 171, English

  [Refereed]

  Scientific journal


• Semimembranosus Release Reduces Tibial Internal Rotation and Flexion Angle in Cruciate-Retaining Total Knee Arthroplasty

  Tomoyuki Matsumoto, Koji Takayama, Hirotsugu Muratsu, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Churchill Livingstone Inc., Sep. 2015, Journal of Arthroplasty, 30(9) (9), 1537 - 1541, English

  [Refereed]

  Scientific journal


• 膝前十字靱帯損傷膝の遺残組織の治癒能 受傷時期が及ぼす影響

  井口貴雄, 松本知之, 高山孝治, 松下雄彦, 荒木大輔, 上藤淳郎, 上藤敦郎, 長井寛斗, 中野直樹, 西田京平, Kuroda Ryosuke, Kurosaka Masahiro

  (公社)日本整形外科学会, Sep. 2015, 日本整形外科学会雑誌, 89(8号) (8号), S1435 - S1435, Japanese

  [Refereed]

  Research society


• 難治性の皮膚潰瘍を伴う麻痺性内反尖足変形に対してTaylor Spatial Frame(TSF)を用いて治療した一例

  竹内一裕, Kanzaki Noriyuki, 鎮西伸顕, 木原伸介, 羽田勝彦, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2015, 日本足の外科学会雑誌, 36(2号) (2号), S311, Japanese

  [Refereed]

  Research society


• 単純X線膝側面像を用いた膝蓋骨不安定症のスクリーニング法の開発

  長井寛斗, Kuroda Ryosuke, 松下雄彦, 松本知之, 荒木大輔, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Sep. 2015, 中部日本整形外科災害外科学会雑誌, 58(秋季学会) (秋季学会), 170 - 170, Japanese

  [Refereed]

  Research society


• 人工足関節置換術前の変形性足関節症の病期は術後の成績に影響があるか?

  Kanzaki Noriyuki, 高倉義典, 高倉義幸, 杜多昭彦, 鎮西伸顕, 木原伸介, 竹内一裕, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2015, 日本足の外科学会雑誌, 36(2号) (2号), S157, Japanese

  [Refereed][Invited]

  Research society


• 人工足関節置換術において術前可動域は術後可動域に影響を与えるか?

  Kanzaki Noriyuki, 高倉義典, 高倉義幸, 杜多昭彦, 鎮西伸顕, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2015, 日本足の外科学会雑誌, 36(1号) (1号), 70 - 72, Japanese

  [Refereed]

  Scientific journal


• 距骨外側突起骨折後の遺残変形に対する足部内視鏡下手術

  羽田勝彦, Kanzaki Noriyuki, 藤代高明, 鎮西伸顕, 木原伸介, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2015, 日本足の外科学会雑誌, 36(1号) (1号), 374 - 377, Japanese

  [Refereed]

  Scientific journal


• 関節リウマチ滑膜細胞のミトコンドリア機能低下が増殖能とMMP3/RANKLの放出に及ぼす影響について

  上羽岳志, Sakai Yoshitada, 森下雅之, 前田俊恒, 福田康治, 赤羽志保, 西本華子, Kuroda Ryosuke, 三浦靖史, Kurosaka Masahiro

  (公社)日本整形外科学会, Sep. 2015, 日本整形外科学会雑誌, 89(8) (8), S1412 - S1412, Japanese

  Research society


• 外傷後の広範囲大腿骨内顆骨壊死に対して骨移植と骨軟骨柱移植術を併用して高位脛骨骨切り術を行った一例

  渡邉秀, 松下雄彦, Kuroda Ryosuke, 松本知之, 長井寛斗, Kurosaka Masahiro

  Sep. 2015, 中部日本整形外科災害外科学会雑誌, 58(秋季学会) (秋季学会), 167, Japanese

  [Refereed]

  Research society


• バイオメカニクスによる運動器疾患の病態解明 前十字靱帯損傷膝の定量評価

  Kuroda Ryosuke, 松下雄彦, 星野祐一, 長宗高樹, 荒木大輔, 松本知之, Kurosaka Masahiro

  (公社)日本整形外科学会, Sep. 2015, 日本整形外科学会雑誌, 89(8号) (8号), S1744 - S1744, Japanese

  [Refereed][Invited]

  Research society


• Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells

  Shingo Miyazaki, Kenichiro Kakutani, Takashi Yurube, Koichiro Maeno, Toru Takada, Zhongying Zhang, Takuto Kurakawa, Yoshiki Terashima, Masaaki Ito, Takeshi Ueha, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka, Kotaro Nishida

  Sep. 2015, ARTHRITIS RESEARCH & THERAPY, 17, 253, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• p21欠損は炎症による変形性関節症を加速させる

  木原伸介, Hayashi Shinya, 藤代高明, Kanzaki Noriyuki, 橋本慎吾, 鎮西伸顕, 羽田勝彦, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2015, 日本整形外科学会雑誌, 89(8号) (8号), S1535, Japanese

  [Refereed]

  Research society


• P21遺伝子はマウス筋損傷モデルにおいて細胞増殖および筋分化を調節する

  鎮西伸顕, Hayashi Shinya, 上羽岳志, 藤代高明, Kanzaki Noriyuki, 橋本慎吾, 木原伸介, 羽田勝彦, Sakai Yoshitada, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2015, 日本整形外科学会雑誌, 89(8号) (8号), S1503, Japanese

  [Refereed]

  Research society


• Factors influencing the outcome of deep infection following total knee arthroplasty

  Naoki Nakano, Tomoyuki Matsumoto, Kazunari Ishida, Nobuhiro Tsumura, Hirotsugu Muratsu, Takafumi Hiranaka, Ryosuke Kuroda, Masahiro Kurosaka

  Sep. 2015, KNEE, 22(4) (4), 328 - 332, English

  [Refereed]

  Scientific journal


• Comparison of the sliding and femoral head rotation among three different femoral head fixation devices for trochanteric fractures

  Nobuaki Chinzei, Takafumi Hiranaka, Takahiro Niikura, Mitsuo Tsuji, Ryosuke Kuroda, Minoru Doita, Masahiro Kurosaka

  Korean Orthopaedic Association, Sep. 2015, CiOS Clinics in Orthopedic Surgery, 7(3) (3), 291 - 297, English

  [Refereed]

  Scientific journal


• Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes

  K. Nagai, T. Matsushita, T. Matsuzaki, K. Takayama, T. Matsumoto, R. Kuroda, M. Kurosaka

  Aug. 2015, Osteoarthritis and Cartilage, 23(8) (8), 1412 - 1420, English

  [Refereed]

  Scientific journal


• 抗RANKL抗体製剤デノスマブ治療における骨粗鬆症患者の骨代謝マーカーおよびQOLの検討

  前田俊恒, 林申也, 三浦靖史, Sakai Yoshitada, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2015, Osteoporosis Japan, 23(Suppl.1) (Suppl.1), 269, Japanese

  [Refereed]

  Research society


• The effect of blocking angiogenesis on anterior cruciate ligament healing following stem cell transplantation

  Koji Takayama, Yohei Kawakami, Yutaka Mifune, Tomoyuki Matsumoto, Ying Tang, James H. Cummins, Nick Greco, Ryosuke Kuroda, Masahiro Kurosaka, Bing Wang, Freddie H. Fu, Johnny Huard

  Aug. 2015, BIOMATERIALS, 60, 9 - 19, English

  [Refereed]

  Scientific journal


• Profiling microRNA expression in fracture nonunions POTENTIAL ROLE OF MICRORNAS IN NONUNION FORMATION STUDIED IN A RAT MODEL

  T. Waki, S. Y. Lee, T. Niikura, T. Iwakura, Y. Dogaki, E. Okumachi, R. Kuroda, M. Kurosaka

  Aug. 2015, BONE & JOINT JOURNAL, 97B(8) (8), 1144 - 1151, English

  [Refereed]

  Scientific journal


• D-dimer levels to screen for venous thromboembolism in patients with fractures caused by high-energy injuries

  Takahiro Niikura, Yoshitada Sakai, Sang Yang Lee, Takashi Iwakura, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Springer Tokyo, Jul. 2015, Journal of Orthopaedic Science, 20(4) (4), 682 - 688, English

  [Refereed]

  Scientific journal


• Superior potential of CD34-positive cells compared to total mononuclear cells for healing of nonunion following bone fracture

  Tomoaki Fukui, Yutaka Mifune, Tomoyuki Matsumoto, Taro Shoji, Yohei Kawakami, Atsuhiko Kawamoto, Masaaki Ii, Hiroshi Akimaru, Tomoya Kuroda, Miki Horii, Ayumi Yokoyama, Cantas Alev, Ryosuke Kuroda, Masahiro Kurosaka, Takayuki Asahara

  Cognizant Communication Corporation, Jul. 2015, Cell Transplantation, 24(7) (7), 1379 - 1393, English

  [Refereed]

  Scientific journal


• Can Platelet-Rich Plasma Protect Rat Achilles Tendons From the Deleterious Effects of Triamcinolone Acetonide?

  Tomoyuki Muto, Takeshi Kokubu, Yutaka Mifune, Atsuyuki Inui, Ryosuke Sakata, Yoshifumi Harada, Fumiaki Takase, Yasuhiro Ueda, Ryosuke Kuroda, Masahiro Kurosaka

  SAGE Publications Ltd, Jul. 2015, Orthopaedic Journal of Sports Medicine, 3(7) (7), 2325967115590968, English

  [Refereed]

  Scientific journal


• 内側膝蓋大腿靱帯再建術後に自家培養軟骨細胞移植術および脛骨粗面前内方移行術を施行した1例

  宮崎邦彦, Kuroda Ryosuke, Matsushita Takehiko, 荒木大輔, 松本知之, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Jul. 2015, 中部日本整形外科災害外科学会雑誌, 58(4号) (4号), 689 - 690, Japanese

  [Refereed]

  Scientific journal


• 抗RANKL抗体製剤デノスマブは骨粗鬆症患者のQOLを向上させる

  前田俊恒, Hayashi Shinya, 三浦靖史, Sakai Yoshitada, Kuroda Ryosuke, Kurosaka Masahiro

  Jul. 2015, 日本骨代謝学会学術集会プログラム抄録集, (33回) (33回), 220, Japanese

  [Refereed]

  Research society


• Influence of Intraoperative Soft Tissue Balance on Postoperative Active Knee Extension in Posterior-Stabilized Total Knee Arthroplasty

  Kanto Nagai, Hirotsugu Muratsu, Tomoyuki Matsumoto, Shunsuke Takahara, Ryosuke Kuroda, Masahiro Kurosaka

  Jul. 2015, Journal of Arthroplasty, 30(7) (7), 1155 - 1159, English

  [Refereed]

  Scientific journal


• Factors affecting intraoperative kinematic patterns and flexion angles in navigated total knee arthroplasty

  Kazunari Ishida, Nao Shibanuma, Tomoyuki Matsumoto, Hiroshi Sasaki, Koji Takayama, Akihiko Toda, Ryosuke Kuroda, Masahiro Kurosaka

  Springer Verlag, Jun. 2015, Knee Surgery, Sports Traumatology, Arthroscopy, 23(6) (6), 1741 - 1747, English

  [Refereed]

  Scientific journal


• Treatment of 50 deep infections after total knee arthroplasty

  Tomoyuki Matsumoto, Kazunari Ishida, Nobuhiro Tsumura, Kanto Nagai, Hirotsugu Muratsu, Yuichi Hida, Takafumi Hiranaka, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2015, Orthopedics, 38(6) (6), e529 - e535

  [Refereed]

  Scientific journal


• 両股関節FAIに対し両側同時股関節鏡視下手術を施行したトップリーグラグビー選手の1例

  鎮西伸顕, 橋本慎吾, 藤代高明, Kanzaki Noriyuki, 荒木大輔, 木原伸介, Kuroda Ryosuke, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4号) (4号), 350 - 350, Japanese

  [Refereed]

  Research society


• 膝前十靱帯前内側束・後外側束が膝関節安定性へ及ぼす役割 三次元電磁気センサーを用いた定量的評価

  荒木大輔, Kuroda Ryosuke, 松下雄彦, 西田京平, 井口貴雄, 長井寛斗, 中野直樹, 高山孝治, 松本知之, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4号) (4号), 353 - 353, Japanese

  [Refereed]

  Research society


• 膝前十字靱帯損傷への取り組み 膝前十字靱帯(ACL)再建膝評価 スポーツ復帰に向けた取り組み

  Kuroda Ryosuke, 松下雄彦, 星野祐一, 荒木大輔, 西田京平, 井口貴雄, 長井寛斗, 高山孝治, 中野直樹, 松本知之, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4号) (4号), 323 - 323, Japanese

  [Refereed]

  Research society


• 膝前十字靱帯再建術後の筋力回復に影響を及ぼす因子の検討

  井口貴雄, 松下雄彦, Kuroda Ryosuke, 荒木大輔, 柴田洋平, 松本知之, 高山孝治, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4号) (4号), 550 - 550, Japanese

  Research society


• 膝蓋骨不安定症の病態と治療 高度脱臼素因例への対応

  松下雄彦, Kuroda Ryosuke, 岡真也, 荒木大輔, 星野祐一, 松本知之, 長井寛斗, 高山孝治, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4号) (4号), 129 - 129, Japanese

  [Refereed]

  Research society


• 膝蓋骨疲労骨折に対する骨接合術後に、偽関節を来したプロバレーボール選手の一例

  森昭嘉, Kuroda Ryosuke, 荒木大輔, 松下雄彦, 高山孝治, 松本知之, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4号) (4号), 201 - 201, Japanese

  [Refereed]

  Research society


• 軟骨再生の臨床経験

  Kuroda Ryosuke, 松下雄彦, 松本知之, 星野祐一, 荒木大輔, 高山孝治, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4号) (4号), 203 - 203, Japanese

  [Invited]

  Research society


• 単顆型人工膝関節置換術における脛骨後方傾斜の変化が及ぼす影響

  高山孝治, 松本知之, 村津裕嗣, 西田京平, 井口貴雄, 中野直樹, 長井寛斗, 荒木大輔, 松下雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4号) (4号), 580 - 580, Japanese

  [Refereed]

  Research society


• 単純X線膝側面像による膝蓋骨不安定症のスクリーニング CT画像との比較

  長井寛斗, Kuroda Ryosuke, 松下雄彦, 荒木大輔, 松本知之, 高山孝治, 中野直樹, 張樹蓉, 井口貴雄, 西田京平, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4号) (4号), 157 - 157, Japanese

  [Refereed]

  Research society


• 足部インピンジメント症候群 AAIS、PAIS以外の足部インピンジメント症候群に対する足部内視鏡手術

  Kanzaki Noriyuki, 熊井司, 田中康仁, 藤代高明, Hayashi Shinya, 橋本慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  Jun. 2015, JOSKAS, 40(4号) (4号), 131, Japanese

  [Refereed]

  Research society


• 人工膝関節置換術における術中関節ギャップと内外側軟部バランスの意義 術後臨床成績への影響

  松本知之, 高山孝治, 村津裕嗣, 石田一成, 中野直樹, 上藤淳郎, 松下雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  Jun. 2015, JOSKAS, 40(4号) (4号), 337, Japanese

  Research society


• 術後感染を併発した人工膝関節全置換術症例の予後に影響する因子 深部感染51症例の検討

  中野直樹, 松本知之, 石田一成, 津村暢宏, 村津裕嗣, 平中崇文, 高山孝治, 松下雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4号) (4号), 223 - 223, Japanese

  Research society


• 股関節唇損傷症例における臨床成績に対するX線学的指標の関連性

  橋本慎吾, 藤代高明, Kanzaki Noriyuki, Kuroda Ryosuke, Kurosaka Masahiro

  Jun. 2015, JOSKAS, 40(4号) (4号), 437, Japanese

  [Refereed]

  Research society


• 距骨外側突起骨折後、腓骨外果骨折後の遺残変形に対する足部内視鏡手術

  木原伸介, Kanzaki Noriyuki, 藤代高明, 橋本慎吾, 鎮西伸顕, Kuroda Ryosuke, Kurosaka Masahiro

  Jun. 2015, JOSKAS, 40(4号) (4号), 462, Japanese

  [Refereed]

  Research society


• 可溶性フィブリン複合体は骨盤・下肢骨折における静脈血栓塞栓症の術後早期スクリーニングに有用か?

  李相亮, Niikura Takahiro, 岩倉崇, Sakai Yoshitada, Kuroda Ryosuke, Kurosaka Masahiro

  Jun. 2015, 骨折, 37(Suppl.) (Suppl.), S199, Japanese

  [Refereed]

  Research society


• スポーツ競技者における膝前十字靱帯再建術後早期の膝伸展筋力回復に影響を及ぼす因子の多変量解析を用いた検討

  西田京平, 上田雄也, 荒木大輔, 松下雄彦, 松本知之, 高山孝治, Kurosaka Masahiro, Kuroda Ryosuke

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4号) (4号), 123 - 123, Japanese

  [Refereed]

  Research society


• Tibialis spastic varus foot without tarsal coalition: a report of two cases

  Noriyuki Kanzaki, Takayuki Nishiyama, Yoshiyuki Takakura, Yoshinori Takakura, Takaaki Fujishiro, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka

  Springer Tokyo, May 2015, Journal of Orthopaedic Science, 20(3) (3), 551 - 554, English

  [Refereed]

  Scientific journal


• Rare non-traumatic periprosthetic femoral fracture with features of an atypical femoral fracture: A case report

  Takahiro Niikura, Sang Yang Lee, Yoshitada Sakai, Ryosuke Kuroda, Masahiro Kurosaka

  BioMed Central Ltd., May 2015, Journal of Medical Case Reports, 9(1) (1), 103, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Does Salter Innominate Osteotomy Predispose the Patient to Acetabular Retroversion in Adulthood?

  Daisuke Kobayashi, Shinichi Satsuma, Maki Kinugasa, Ryosuke Kuroda, Masahiro Kurosaka

  May 2015, CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 473(5) (5), 1755 - 1762, English

  [Refereed]

  Scientific journal


• Fully automated determination of femoral coordinate system in CT image based on epicondyles

  Yosuke Uozumi, Kouki Nagamune, Naoki Nakano, Kanto Nagai, Daisuke Araki, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  May 2015, Journal of Advanced Computational Intelligence and Intelligent Informatics, 19(3) (3), 372 - 380

  [Refereed]

  Scientific journal


• 様々な病態が重なり整復不能となった長腓骨筋腱脱臼の1例

  鎮西伸顕, Kanzaki Noriyuki, Hayashi Shinya, 木原伸介, 羽田勝彦, 酒井良忠, 秋末敏宏, 西山隆之, Kuroda Ryosuke, Kurosaka Masahiro

  May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S254, Japanese

  Research society


• 反復性膝蓋骨脱臼患者における内側膝蓋大腿靱帯再建術前後の膝伸展筋力の変化

  松下雄彦, Kuroda Ryosuke, 松本知之, 荒木大輔, 酒井良忠, Kurosaka Masahiro

  (公社)日本リハビリテーション医学会, May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S217 - S217, Japanese

  [Refereed]

  Research society


• 炭酸ガス経皮吸収はラット前脛骨筋損傷モデルの治癒を促進する

  赤羽志保, 酒井良忠, 上羽岳志, 西本華子, 井上美帆, 小林慶通, 原田理沙, Niikura Takahiro, Kuroda Ryosuke, Kurosaka Masahiro

  May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S426, Japanese

  [Refereed]

  Research society


• 抗RANKL抗体製剤デノスマブは骨粗鬆症患者のQOLを向上させる

  前田俊恒, Hayashi Shinya, 三浦靖史, 酒井良忠, Kuroda Ryosuke, Kurosaka Masahiro

  May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S225, Japanese

  Research society


• 筋損傷後の治癒過程におけるp21の役割

  鎮西伸顕, Hayashi Shinya, Kanzaki Noriyuki, 上羽岳志, 木原伸介, 羽田勝彦, 酒井良忠, 秋末敏宏, Kuroda Ryosuke, Kurosaka Masahiro

  May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S208, Japanese

  Research society


• デノスマブによる骨粗鬆症治療の治療効果

  Hayashi Shinya, 前田俊恒, 三浦靖史, 酒井良忠, Kuroda Ryosuke, Kurosaka Masahiro

  May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S225, Japanese

  Research society


• スポーツ競技者における膝前十字靱帯再建術後早期の良好な膝伸展筋力回復に関する要因の検討

  荒木大輔, 松下雄彦, 松本知之, 酒井良忠, Kurosaka Masahiro, Kuroda Ryosuke

  (公社)日本リハビリテーション医学会, May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S254 - S254, Japanese

  [Refereed]

  Research society


• Tri-Lock Bone Preservation StemのDEXAによる術後骨密度変化の検討

  羽田勝彦, Hayashi Shinya, Kanzaki Noriyuki, 鎮西伸顕, 木原伸介, 酒井良忠, 秋末敏宏, Kuroda Ryosuke, Kurosaka Masahiro

  May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S370, Japanese

  Research society


• P21 Deficiency Delays Regeneration of Skeletal Muscular Tissue

  Nobuaki Chinzei, Shinya Hayashi, Takeshi Ueha, Takaaki Fujishiro, Noriyuki Kanzaki, Shingo Hashimoto, Shuhei Sakata, Shinsuke Kihara, Masahiko Haneda, Yoshitada Sakai, Ryosuke Kuroda, Masahiro Kurosaka

  May 2015, PLOS ONE, 10(5) (5), e0125765, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 片脚反復横跳び動作時の切り返し方向の違いが足関節モーメントにおよぼす影響

  伊藤 浩充, 瀧口 耕平, 柴田 洋平, 大久保 吏司, 吉矢 晋一, 黒田 良祐, 黒坂 昌弘

  (公社)日本理学療法士協会, Apr. 2015, 理学療法学, 42(Suppl.2) (Suppl.2), P1 - 0168, Japanese


• スポーツ実施者における膝前十字靱帯再建術後6ヵ月での膝伸展筋力回復に関連する因子およびカットオフ値の検討

  上田 雄也, 荒木 大輔, 松下 雄彦, 瀧口 耕平, 柴田 洋平, 小野 くみ子, 小野 玲, 松本 知之, 高山 孝治, 酒井 良忠, 黒坂 昌弘, 黒田 良祐

  (公社)日本理学療法士協会, Apr. 2015, 理学療法学, 42(Suppl.2) (Suppl.2), O - 0036, Japanese

  [Refereed]


• SIMVASTATIN STIMULATES MENISCAL HEALING IN A RABBIT MENISCAL DEFECT MODEL

  S. Zhang, T. Matsushita, T. Matsuzaki, T. Matsuomoto, K. Takayama, K. Nagai, S. Oka, Y. Tabata, M. Kurosaka, R. Kuroda

  Apr. 2015, OSTEOARTHRITIS AND CARTILAGE, 23, A273 - A274, English

  [Refereed]

  Scientific journal


• The tibia first technique with tensor measurement is useful to predict the soft tissue tension after implantation in unicompartmental knee arthroplasty

  Koji Takayama, Tomoyuki Matsumoto, Hirotsugu Muratsu, Kazunari Ishida, Nao Shibanuma, Daisuke Araki, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Apr. 2015, INTERNATIONAL ORTHOPAEDICS, 39(4) (4), 667 - 671, English

  [Refereed]

  Scientific journal


• The contributing factors of tapered wedge stem alignment during mini-invasive total hip arthroplasty

  Shinya Hayashi, Takaaki Fujishiro, Shingo Hashimoto, Noriyuki Kanzaki, Ryosuke Kuroda, Masahiro Kurosaka

  Apr. 2015, Journal of Orthopaedic Surgery and Research, 10, 52, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Age-dependent healing potential of anterior cruciate ligament remnant-derived cells

  Naoki Nakano, Tomoyuki Matsumoto, Koji Takayama, Takehiko Matsushita, Daisuke Araki, Atsuo Uefuji, Kanto Nagai, Shurong Zhang, Takao Inokuchi, Kyohei Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2015, American Journal of Sports Medicine, 43(3) (3), 700 - 708, English

  [Refereed]

  Scientific journal


• 膝前十字靱帯再建術の新たなる展開 移植腱の骨内での癒合促進と術後筋力回復への新たなる試み

  Kurosaka Masahiro, Kuroda Ryosuke, 松下雄彦, 松本知之, 高山孝治, 酒井良忠

  Mar. 2015, 日本整形外科学会雑誌, 89(2号) (2号), S287, Japanese

  Research society


• 内側膝蓋大腿靱帯再建術後に自家培養軟骨細胞移植術および脛骨粗面前内方移行術を施行した一例

  宮崎邦彦, Kuroda Ryosuke, 松下雄彦, 荒木大輔, 松本知之, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Mar. 2015, 中部日本整形外科災害外科学会雑誌, 58(春季学会) (春季学会), 102 - 102, Japanese

  [Refereed]

  Research society


• 内側膝蓋大腿靱帯再建術においてX線透視下に決定した大腿骨骨孔位置で再建靱帯は適切な長さ変化を示すか

  松下雄彦, Kuroda Ryosuke, 星野祐一, 佐々木謙, 荒木大輔, 岡真也, 松本知之, 西澤勇一朗, 長井寛斗, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2015, 日本整形外科学会雑誌, 89(3号) (3号), S745 - S745, Japanese

  [Refereed]

  Research society


• 単顆型人工膝関節置換術における脛骨後方傾斜とcomponent gapの関係

  高山孝治, 松本知之, 村津裕嗣, 石田一成, 柴沼均, 荒木大輔, 松下雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2015, 日本整形外科学会雑誌, 89(3号) (3号), S713 - S713, Japanese

  Research society


• 前十字靱帯解剖学的二重束再建術において大腿骨側骨孔間距離が術後骨孔拡大に及ぼす影響

  荒木大輔, Kuroda Ryosuke, 魚住洋祐, 長宗高樹, 松下雄彦, 松本知之, 高山孝治, 星野祐一, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2015, 日本整形外科学会雑誌, 89(3号) (3号), S744 - S744, Japanese

  [Refereed]

  Research society


• 人工膝関節全置換術における術中軟部組織バランスが膝蓋大腿関節接触圧に及ぼす影響

  松本知之, 高山孝治, 川上洋平, 佐々木宏, 柴沼均, 石田一成, 村津裕嗣, 松下雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2015, 日本整形外科学会雑誌, 89(3号) (3号), S714 - S714, Japanese

  [Refereed]

  Research society


• 骨盤・下肢骨折後の静脈血栓塞栓症発生予測因子としてのトロンビン・アンチトロンビンIII複合体の有用性

  李相亮, Niikura Takahiro, Sakai Yoshitada, 岩倉崇, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2015, 日本整形外科学会雑誌, 89(3号) (3号), S623, Japanese

  Research society


• Retrograde intramedullary nailing for the treatment of femoral medial condyle fracture nonunion

  Niikura Takahiro, Lee Sangyang, Sakai Yoshitada, Nishida Kotaro, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2015, Strategies Trauma Limb Reconstr, English

  [Refereed]

  Scientific journal


• Oxidative Stress-induced Apoptosis and Matrix Loss of Chondrocytes Is Inhibited by Eicosapentaenoic Acid

  Shuhei Sakata, Shinya Hayashi, Takaaki Fujishiro, Kohei Kawakita, Noriyuki Kanzaki, Shingo Hashimoto, Kenjiro Iwasa, Nobuaki Chinzei, Shinsuke Kihara, Masahiko Haneda, Takeshi Ueha, Takayuki Nishiyama, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2015, JOURNAL OF ORTHOPAEDIC RESEARCH, 33(3) (3), 359 - 365, English

  [Refereed]

  Scientific journal


• Modern TKAに必要なアライメントとは 適切な冠状断アライメント

  松本知之, 西田京平, 高山孝治, 中野直樹, 松下雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2015, 日本整形外科学会雑誌, 89(3号) (3号), S574, Japanese

  [Refereed]

  Research society


• Cyclin-dependent kinase inhibitor p21 does not impact embryonic endochondral ossification in mice

  Nobuaki Chinzei, Shinya Hayashi, Shingo Hashimoto, Noriyuki Kanzaki, Kenjiro Iwasa, Shuhei Sakata, Shinsuke Kihara, Takaaki Fujishiro, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2015, MOLECULAR MEDICINE REPORTS, 11(3) (3), 1601 - 1608, English

  [Refereed]

  Scientific journal


• Comparative analysis of rat mesenchymal stem cells derived from slow and fast skeletal muscle in vitro

  Etsuko Okumachi, Sang Yang Lee, Takahiro Niikura, Takashi Iwakura, Yoshihiro Dogaki, Takahiro Waki, Shunsuke Takahara, Takeshi Ueha, Yoshitada Sakai, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2015, INTERNATIONAL ORTHOPAEDICS, 39(3) (3), 569 - 576, English

  [Refereed]

  Scientific journal


• A radiographic analysis of alignment of the lower extremities - initiation and progression of varus-type knee osteoarthritis

  T. Matsumoto, M. Hashimura, K. Takayama, K. Ishida, Y. Kawakami, T. Matsuzaki, N. Nakano, T. Matsushita, R. Kuroda, M. Kurosaka

  Feb. 2015, OSTEOARTHRITIS AND CARTILAGE, 23(2) (2), 217 - 223, English

  [Refereed]

  Scientific journal


• A comparison of ligament tensions between intra- and extra-articular measurement in anterior cruciate ligament reconstruction

  Shogo Kawaguchi, Kouki Nagamune, Yuichiro Nishizawa, Shinya Oka, Daisuke Araki, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Fuji Technology Press, 2015, Journal of Advanced Computational Intelligence and Intelligent Informatics, 19(6) (6), 778 - 784, English

  Scientific journal


• An Evaluation of Force Difference Between Left and Right Difference Around Greater Trochanter Under Pelvic Belt.

  Shimizu Yusuke, Nagamune Kouki, Ooe Keisuke, Sangyang Lee, Niikura Takahiro, Kuroda Ryousuke, Kurosaka Masahiro

  A pelvic belt is a tool of first aid for the pelvic fracture patients . The purpose is to stabilize the unstable pelvis and to control bleeding from arteries and organs inside the pelvis . However, there is no pelvic belt which takes into account for the differences of race and gender, and evaluation during surgery . The purpose of this study is to develop an evaluation system for the pelvic belt and worn to be a person. It will be a basis for the future development of the pelvic band. Especially the pelvic band has a risk of decubitus where the pelvic band fixes the major trochanter strongly. Naturally, load generated between the body and pelvic belt is large, because it is required to fix the pelvic fracture. Therefore, we evaluate the distribution and load generated between the body and pelvis belt .

  Japan Society for Fuzzy Theory and Intelligent Informatics, 2015, Proceedings of the Fuzzy System Symposium, 31, 534 - 535, Japanese


• 前十字靱帯再建手術後6ヵ月の膝関節伸展筋力健患比の予測

  柴田 洋平, 松下 雄彦, 荒木 大輔, 木田 晃弘, 瀧口 耕平, 上田 雄也, 小野 くみ子, 松本 知之, 高山 孝治, 酒井 良忠, 黒坂 昌弘, 黒田 良祐

  スポーツ傷害フォーラム, Jan. 2015, スポーツ傷害, 20, 3 - 3, Japanese


• スポーツ競技者における膝前十字靱帯再建術後早期の膝伸展筋力回復に影響を及ぼす因子の検討

  西田 京平, 上田 雄也, 荒木 大輔, 松下 雄彦, 松本 知之, 高山 孝治, 黒坂 昌弘, 黒田 良祐

  スポーツ傷害フォーラム, Jan. 2015, スポーツ傷害, 20, 5 - 5, Japanese


• ACL再建術 競技復帰へ向けた取り組みと問題点 スポーツ復帰にむけた再建膝評価

  松下 雄彦, 黒田 良祐, 荒木 大輔, 柴田 洋平, 上田 雄也, 瀧口 耕平, 木田 晃弘, 西田 京平, 井口 貴雄, 松本 知之, 高山 幸治, 黒坂 昌弘

  スポーツ傷害フォーラム, Jan. 2015, スポーツ傷害, 20, 35 - 35, Japanese


• スポーツ競技者における膝前十字靱帯再建術後1年での跳躍動作に影響を及ぼす因子の検討

  上田 雄也, 松下 雄彦, 荒木 大輔, 木田 晃弘, 瀧口 耕平, 柴田 洋平, 小野 くみ子, 松本 知之, 高山 孝治, 酒井 良忠, 黒坂 昌弘, 黒田 良祐

  スポーツ傷害フォーラム, Jan. 2015, スポーツ傷害, 20, 4 - 4, Japanese


• Late Onset Prosthetic Hip Joint Infection in Two Patients of Rheumatoid Arthritis Treated With Etanercept

  Hayashi Shinya, Sakai Yoshitada, Fujishiro Takaaki, Hashimoto Shingo, Kanzaki Noriyuki, Kuroda Ryosuke, Kurosaka Masahiro

  2015, ARCHIVES OF RHEUMATOLOGY, 30(2) (2), 168 - 171, English

  [Refereed]

  Scientific journal


• Surgical Management of the Peroneus Quartus Muscle for Bilateral Ankle Pain A Case Report

  Nobuaki Chinzei, Noriyuki Kanzaki, Yoshinori Takakura, Yoshiyuki Takakura, Akihiko Toda, Takaaki Fujishiro, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2015, JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION, 105(1) (1), 85 - 91, English

  [Refereed]

  Scientific journal


• Evaluation of implant alignment in navigated unicompartmental knee arthroplasty: A comparison of 2D and 3D imaging

  Kazunari Ishida, Akihiko Toda, Nao Shibanuma, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka

  ARSMB-KVBMG, 2015, Acta Orthopaedica Belgica, 81(4) (4), 654 - 661, English

  [Refereed]

  Scientific journal


• Acute Popliteal Artery Occlusion after Revision Total Knee Arthroplasty

  TsujimotoR, Matsumoto Tomoyuki, TakayamaK, KawakamiY, KamimuraM, Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  Acute arterial occlusions are a rare complication of total knee arthroplasty (TKA). However, in revision TKA, the risk of such complications is higher and these complications can lead to amputation if not adequately treated. We describe a case of acute popliteal artery occlusion 4 hours after second revision TKA in a patient with a history of several surgical procedures because of periprosthetic infection at a previous hospital. Revascularization was achieved via bypass grafting and amputation was narrowly avoided despite time lag after symptom onset to revascularization. In this case, it was possible that the arterial disease that accompanied the vascular endothelium injury such as pseudoaneurysm had existed since the previous surgery at another hospital and was destroyed by the surgical procedure, which led to the formation of thrombosis and arterial occlusion. Preoperative evaluation of the arterial condition should be considered to avoid acute arterial occlusive disease, especially in patients who had several previous surgical procedures.

  2015, Case Rep Orthop, 2015, 672164 - 672164, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• SDF-1/CXCR4 Axis in Tie2-Lineage Cells Including Endothelial Progenitor Cells Contributes to Bone Fracture Healing

  Yohei Kawakami, Masaaki Ii, Tomoyuki Matsumoto, Ryosuke Kuroda, Tomoya Kuroda, Sang-Mo Kwon, Atsuhiko Kawamoto, Hiroshi Akimaru, Yutaka Mifune, Taro Shoji, Tomoaki Fukui, Masahiro Kurosaka, Takayuki Asahara

  Jan. 2015, JOURNAL OF BONE AND MINERAL RESEARCH, 30(1) (1), 95 - 105, English

  [Refereed]

  Scientific journal


• Joint gap assessment with a tensor is useful for the selection of insert thickness in unicompartmental knee arthroplasty

  Koji Takayama, Tomoyuki Matsumoto, Hirotsugu Muratsu, Atsuo Uefuji, Naoki Nakano, Kanto Nagai, Tokio Matsuzaki, Shinya Oka, Kazunari Ishida, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2015, Clinical Biomechanics, 30(1) (1), 95 - 99, English

  [Refereed]

  Scientific journal


• Rate of venous thromboembolism after complex lower-limb fracture surgery without pharmacological prophylaxis

  Takahiro Niikura, Yoshitada Sakai, Sang Yang Lee, Takashi Iwakura, Ryosuke Kuroda, Masahiro Kurosaka

  2015, JOURNAL OF ORTHOPAEDIC SURGERY, 23(1) (1), 37 - 40, English

  [Refereed]

  Scientific journal


• Accurate and easy measurement of sliding distance of intramedullary nail in trochanteric fracture

  Nobuaki Chinzei, Takafumi Hiranaka, Takahiro Niikura, Takaaki Fujishiro, Shinya Hayashi, Noriyuki Kanzaki, Shingo Hashimoto, Yoshitada Sakai, Ryosuke Kuroda, Masahiro Kurosaka

  Korean Orthopaedic Association, 2015, CiOS Clinics in Orthopedic Surgery, 7(2) (2), 152 - 157, English

  [Refereed]

  Scientific journal


• Topical Cutaneous CO2 Application by Means of a Novel Hydrogel Accelerates Fracture Repair in Rats

  Takaaki Koga, Takahiro Niikura, Sang Yang Lee, Etsuko Okumachi, Takeshi Ueha, Takashi Iwakura, Yoshitada Sakai, Masahiko Miwa, Ryosuke Kuroda, Masahiro Kurosaka

  Dec. 2014, JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 96A(24) (24), 2077 - 2084, English

  [Refereed]

  Scientific journal


• Intraoperative Platelet-Rich Plasma Does Not Improve Outcomes of Total Knee Arthroplasty

  Masayuki Morishita, Kazunari Ishida, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka, Nobuhiro Tsumura

  Dec. 2014, JOURNAL OF ARTHROPLASTY, 29(12) (12), 2337 - 2341, English

  [Refereed]

  Scientific journal


• Intra-articular administration of gelatin hydrogels incorporating rapamycin-micelles reduces the development of experimental osteoarthritis in a murine model

  Tokio Matsuzaki, Takehiko Matsushita, Yasuhiko Tabata, Takashi Saito, Tomoyuki Matsumoto, Kanto Nagai, Ryosuke Kuroda, Masahiro Kurosaka

  Dec. 2014, Biomaterials, 35(37) (37), 9904 - 9911, English

  [Refereed]

  Scientific journal


• Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis

  Koji Takayama, Yohei Kawakami, Makoto Kobayashi, Nick Greco, James H. Cummins, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H. Fu, Johnny Huard

  BioMed Central Ltd., Nov. 2014, Arthritis Research and Therapy, 16(1) (1), 482, English

  [Refereed]

  Scientific journal


• A new bioabsorbable cotton-textured synthetic polymer scaffold for osteochondral repair

  Ryosuke Sakata, Takeshi Kokubu, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Hiroyuki Fujioka, Ryosuke Kuroda, Masahiro Kurosaka

  Nov. 2014, INTERNATIONAL ORTHOPAEDICS, 38(11) (11), 2413 - 2420, English

  [Refereed]

  Scientific journal


• Automated extraction of tibial eminence in CT image using shape matching

  Yosuke Uozumi, Kouki Nagamune, Naoki Nakano, Kanto Nagai, Daisuke Araki, Yuichi Hosliino, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Oct. 2014, World Automation Congress Proceedings, 336 - 339

  [Refereed]

  International conference proceedings


• 片脚反復横跳び動作時の切り返し方向の違いと膝関節内外反トルクの関係

  伊藤 浩充, 瀧口 耕平, 柴田 洋平, 大久保 吏司, 吉田 昌平, 吉矢 晋一, 黒田 良祐, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2014, 日本臨床スポーツ医学会誌, 22(4) (4), S176 - S176, Japanese


• Involvement of ERCC1 in the pathogenesis of osteoarthritis through the modulation of apoptosis and cellular senescence.

  Koji Takayama, Yohei Kawakami, Sahnghoon Lee, Nick Greco, Mitra Lavasani, Yutaka Mifune, James H Cummins, Takashi Yurube, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H Fu, Johnny Huard

  DNA damage is a cause of age related pathologies, including osteoarthritis (OA). Excision repair cross complementation group 1 (ERCC1) is an endonuclease required for DNA damage repair. In this study we investigated the function of ERCC1 in chondrocytes and its association with the pathophysiology of OA. ERCC1 expression in normal and osteoarthritic cartilage was assessed, as were changes in ERCC1 expression in chondrocytes under catabolic stress. Inhibiting ERCC1 in chondrocytes under interleukin-1β stimulation using small interfering RNA (siRNA) was also evaluated. Finally, cellular senescence and apoptosis were examined in relation to ERCC1 function. ERCC1 expression was decreased in OA cartilage and increased within 4 h of exposure to interleukin (IL)-1β, but decreased after 12 h. The inhibition of ERCC1 by siRNA increased the expression of matrix metallopeptidase 13 and decreased collagen type II. ERCC1 inhibition also increased the number of apoptotic and senescent cells. The inhibition of ERCC1 in chondrocytes increased their expression of OA related proteins, apoptosis, cellular senescence, and hypertrophic-like changes which suggest that ERCC1 is critical for protecting human chondrocytes (HCs) from catabolic stresses and provides insights into the pathophysiology of OA and a potential target for its treatment. (191)

  Oct. 2014, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(10) (10), 1326 - 32, English, International magazine

  [Refereed]


• 様々な病態が重なり整復不能となった腓骨筋腱脱臼の1例

  鎮西 伸顕, Kanzaki Noriyuki, Fujishiro Takaaki, 坂田 周平, 木原 伸介, 羽田 勝彦, 西山 隆之, Kuroda Ryosuke, Kurosaka Masahiro

  Oct. 2014, 日本足の外科学会雑誌, 35(2号) (2号), S308, Japanese

  [Refereed]

  Research society


• 内側膝蓋大腿靱帯再建手術症例における術後早期の膝関節可動域に影響する因子

  柴田 洋平, Matsushita Takehiko, 荒木 大輔, 木田 晃弘, 瀧口 耕平, 上田 雄也, 松本 知之, 高山 孝治, 酒井 良忠, Kurosaka Masahiro, Kuroda Ryosuke

  (一社)日本臨床スポーツ医学会, Oct. 2014, 日本臨床スポーツ医学会誌, 22(4号) (4号), S173 - S173, Japanese

  Research society


• 足部に骨軟骨腫を生じた2例

  木原 伸介, Kanzaki Noriyuki, 秋末 敏宏, Fujishiro Takaaki, 鎮西 伸顕, 羽田 勝彦, Kuroda Ryosuke, Kurosaka Masahiro

  Oct. 2014, 日本足の外科学会雑誌, 35(2号) (2号), S212, Japanese

  [Refereed]

  Research society


• 前十字靱帯再建術時に施行した半月板縫合術の術後再鏡視評価と治療成績に及ぼす因子の検討

  Matsushita Takehiko, Kuroda Ryosuke, 長井 寛斗, 松本 知之, 星野 祐一, 荒木 大輔, Kurosaka Masahiro

  (一社)日本臨床スポーツ医学会, Oct. 2014, 日本臨床スポーツ医学会誌, 22(4号) (4号), S213 - S213, Japanese

  [Refereed]

  Research society


• 人工足関節置換術において術前可動域は術後可動域に影響を与えるか?

  Kanzaki Noriyuki, 高倉 義典, 高倉 義幸, 杜多 昭彦, Fujishiro Takaaki, 鎮西 伸顕, 木原 伸介, 羽田 勝彦, Kuroda Ryosuke, Kurosaka Masahiro

  Oct. 2014, 日本足の外科学会雑誌, 35(2号) (2号), S276, Japanese

  [Refereed]

  Research society


• 距骨骨嚢腫に対して鏡視下病巣掻爬および人工骨充填をおこなった1例

  Fujishiro Takaaki, Kanzaki Noriyuki, 鎮西 伸顕, 木原 伸介, 羽田 勝彦, Kuroda Ryosuke, Kurosaka Masahiro

  Oct. 2014, 日本足の外科学会雑誌, 35(2号) (2号), S360, Japanese

  Research society


• 距骨外側突起骨折後、腓骨外果骨折後の遺残変形に対する足部内視鏡手術

  羽田 勝彦, Kanzaki Noriyuki, Fujishiro Takaaki, 坂田 周平, 鎮西 伸顕, 木原 伸介, 西山 隆之, Kuroda Ryosuke, Kurosaka Masahiro

  Oct. 2014, 日本足の外科学会雑誌, 35(2号) (2号), S360, Japanese

  [Refereed]

  Research society


• スポーツ競技者における膝前十字靱帯再建術後早期の良好な膝伸展筋力回復に関する要因の検討

  上田 雄也, 荒木 大輔, Matsushita Takehiko, 瀧口 耕平, 柴田 洋平, 松本 知之, 高山 孝治, 酒井 良忠, Kurosaka Masahiro, Kuroda Ryosuke

  (一社)日本臨床スポーツ医学会, Oct. 2014, 日本臨床スポーツ医学会誌, 22(4号) (4号), S211 - S211, Japanese

  Research society


• Temporary Inductions of Matrix Metalloprotease-3 (MMP-3) Expression and Cell Apoptosis Are Associated With Tendon Degeneration or Rupture after Corticosteroid Injection

  Tomoyuki Muto, Takeshi Kokubu, Yutaka Mifune, Atsuyuki Inui, Yoshifumi Harada, Fumiaki Takase, Ryosuke Kuroda, Masahiro Kurosaka

  Oct. 2014, JOURNAL OF ORTHOPAEDIC RESEARCH, 32(10) (10), 1297 - 1304, English

  [Refereed]

  Scientific journal


• Simulation of the optimal femoral insertion site in medial patellofemoral ligament reconstruction

  Shinya Oka, Takehiko Matsushita, Seiji Kubo, Tomoyuki Matsumoto, Hiroyuki Tajimi, Masahiro Kurosaka, Ryosuke Kuroda

  Oct. 2014, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 22(10) (10), 2364 - 2371, English

  [Refereed]

  Scientific journal


• Clinical outcomes of medial patellofemoral ligament reconstruction in patients with an increased tibial tuberosity-trochlear groove distance

  Takehiko Matsushita, Ryosuke Kuroda, Shinya Oka, Tomoyuki Matsumoto, Koji Takayama, Masahiro Kurosaka

  Oct. 2014, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 22(10) (10), 2438 - 2444, English

  [Refereed]

  Scientific journal


• Bilateral medial patellofemoral ligament reconstruction in high-level athletes

  Yuichi Kuroda, Takehiko Matsushita, Tomoyuki Matsumoto, Yohei Kawakami, Masahiro Kurosaka, Ryosuke Kuroda

  Oct. 2014, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 22(10) (10), 2465 - 2469, English

  [Refereed]

  Scientific journal


• An automated determination of Blumensaat line using fuzzy system based on physician experience from femur CT image

  Yosuke Uozumi, Kouki Nagamune, Naoki Nakano, Kanto Nagai, Yuichiro Nishizawa, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Sep. 2014, IEEE International Conference on Fuzzy Systems, 1831 - 1836

  [Refereed]

  International conference proceedings


• A three-dimensional evaluation of EndoButton displacement direction after anterior cruciate ligament reconstruction in CT image using tunnel axis

  Yosuke Uozumi, Kouki Nagamune, Naoki Nakano, Kanto Nagai, Yuichiro Nishizawa, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Sep. 2014, Journal of Advanced Computational Intelligence and Intelligent Informatics, 18(5) (5), 830 - 838

  [Refereed]

  Scientific journal


• 人工膝関節全置換術における膝蓋大腿関節接触圧の検討 Fixed bearingとMobile bearingTKAの比較

  高山 孝治, 松本 知之, 石田 一成, Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2014, 中部日本整形外科災害外科学会雑誌, 57(秋季学会) (秋季学会), 183, Japanese

  [Refereed]

  Research society


• 距骨に生じた骨軟骨腫の一例

  木原 伸介, Kanzaki Noriyuki, 秋末 敏宏, 鎮西 伸顕, Fujishiro Takaaki, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2014, 日本足の外科学会雑誌, 35(1号) (1号), 334 - 336, Japanese

  [Refereed]

  Scientific journal


• TNK人工足関節置換術後の足関節可動域に与えるインプラントの設置位置の影響

  Kanzaki Noriyuki, 高倉 義典, 高倉 義幸, 杜多 昭彦, 柴沼 均, Fujishiro Takaaki, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2014, 日本足の外科学会雑誌, 35(1号) (1号), 68 - 70, Japanese

  [Refereed]

  Scientific journal


• Three-Dimensional Analysis of Bone Tunnel Changes After Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction Using Multidetector-Row Computed Tomography

  Daisuke Araki, Ryosuke Kuroda, Tomoyuki Matsumoto, Kouki Nagamune, Takehiko Matsushita, Yuichi Hoshino, Shinya Oka, Yuichiro Nishizawa, Masahiro Kurosaka

  Sep. 2014, AMERICAN JOURNAL OF SPORTS MEDICINE, 42(9) (9), 2234 - 2241, English

  [Refereed]

  Scientific journal


• Efficient derivation of osteoprogenitor cells from induced pluripotent stem cells for bone regeneration

  Yoshihiro Dogaki, Sang Yang Lee, Takahiro Niikura, Takashi Iwakura, Etsuko Okumachi, Takahiro Waki, Kenichiro Kakutani, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Sep. 2014, INTERNATIONAL ORTHOPAEDICS, 38(9) (9), 1779 - 1785, English

  [Refereed]

  Scientific journal


• ACL再建術の中長期成績 膝前十字靱帯(ACL)再建術の中長期成績

  Kuroda Ryosuke, Matsushita Takehiko, 荒木 大輔, 高山 孝治, 松本 知之, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Sep. 2014, 中部日本整形外科災害外科学会雑誌, 57(秋季学会) (秋季学会), 54 - 54, Japanese

  [Refereed][Invited]

  Research society


• 膝前十字靱帯再建術後の治癒能力の年齢による差異に関する検討

  中野 直樹, 松本 知之, 高山 孝治, Matsushita Takehiko, 松崎 時夫, 上藤 淳郎, 長井 寛斗, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2014, 日本整形外科学会雑誌, 88(8号) (8号), S1429, Japanese

  [Refereed]

  Research society


• 膝前十字靱帯再建術における移植腱初期固定張力の関節内への伝達率の検討

  長井 寛斗, Kuroda Ryosuke, 星野 祐一, 西澤 勇一郎, 荒木 大輔, 中野 直樹, Matsushita Takehiko, 松本 知之, 高山 孝治, 長宗 高樹, Kurosaka Masahiro

  Aug. 2014, 日本整形外科学会雑誌, 88(8号) (8号), S1611, Japanese

  [Refereed]

  Research society


• 膝関節軟骨損傷に対する治療戦略 スポーツ外傷からOAまで

  Kuroda Ryosuke

  Aug. 2014, 日本整形外科スポーツ医学会雑誌, 34(4号) (4号), 355, Japanese

  [Invited]

  Research society


• 短期間の炭酸ガス経皮吸収がラット前脛骨筋へ及ぼす影響についての検討

  赤羽 志保, 酒井 良忠, 上羽 岳志, 西本 華子, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2014, 日本整形外科学会雑誌, 88(8号) (8号), S1576, Japanese

  [Refereed]

  Research society


• 筋損傷後の治癒過程におけるp21の役割

  木原 伸介, Hayashi Shinya, 上羽 岳志, 橋本 慎吾, Fujishiro Takaaki, Kanzaki Noriyuki, 鎮西 伸顕, 坂田 周平, 酒井 良忠, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2014, 日本整形外科学会雑誌, 88(8号) (8号), S1576, Japanese

  [Refereed]

  Research society


• バイオメカニクスと手術・リハビリテーションへの応用 前十字靱帯損傷膝の定量評価

  Kuroda Ryosuke, 長井 寛斗, 中野 直樹, 荒木 大輔, Matsushita Takehiko, 星野 祐一, 長宗 高樹, 松本 知之, 高山 孝治, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2014, 日本整形外科学会雑誌, 88(8号) (8号), S1607 - S1607, Japanese

  [Refereed][Invited]

  Research society


• シンバスタチンのヒト半月板に対する有効性の検討

  張 樹蓉, Matsushita Takehiko, 松本 知之, 高山 孝治, 松崎 時夫, 岡 真也, 長井 寛斗, 上藤 淳郎, 中野 直樹, Kurosaka Masahiro, Kuroda Ryosuke

  Aug. 2014, 日本整形外科学会雑誌, 88(8号) (8号), S1658, Japanese

  [Invited]

  Research society


• Transcutaneous application of CO2 enhances the antitumor effect of radiation therapy in human malignant fibrous histiocytoma

  Yasuo Onishi, Toshihiro Akisue, Teruya Kawamoto, Takeshi Ueha, Hitomi Hara, Mitsunori Toda, Risa Harada, Masaya Minoda, Masayuki Morishita, Ryohei Sasaki, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Aug. 2014, INTERNATIONAL JOURNAL OF ONCOLOGY, 45(2) (2), 732 - 738, English

  [Refereed]

  Scientific journal


• ACL再断裂例への対応 再手術率、術式、成績 ACL再断裂例への対応

  Kuroda Ryosuke, 長井 寛斗, 荒木 大輔

  (一社)日本整形外科スポーツ医学会, Aug. 2014, 日本整形外科スポーツ医学会雑誌, 34(4号) (4号), 449 - 449, Japanese

  [Invited]

  Research society


• Non-anatomical Anterior Cruciate Ligament Remnants Do Not Contribute Dynamic Knee Stability ˜Quantitative Measurement Of The Pivot Shift Test˜

  Kanto Nagai, Ryosuke Kuroda, Daisuke Araki, Yuichiro Nishizawa, Takehiko Matsushita, Yuichi Hoshino, Tomoyuki Matsumoto, Koji Takayama, Kouki Nagamune, Masahiro Kurosaka

  Jul. 2014, Orthopaedic Journal of Sports Medicine, 2

  [Refereed]

  Scientific journal


• Early-onset severe neuromatous pain of the infrapatellar branch of the saphenous nerve after total knee arthroplasty

  Kanto Nagai, Hirotsugu Muratsu, Tomoyuki Matsumoto, Isao Fujibayashi, Ryosuke Kuroda, Masahiro Kurosaka

  Jul. 2014, Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, 1(3) (3), 102 - 105

  [Refereed]

  Scientific journal


• 変形性足関節症の治療戦略:現状と未来 人工足関節置換術の現状と未来

  Kanzaki Noriyuki, 高倉 義典, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  Jul. 2014, JOSKAS, 39(4号) (4号), 307, Japanese

  [Refereed]

  Research society


• 膝前十字靱帯再建術後に仮性動脈瘤を生じた1例

  壺坂 正徳, Matsushita Takehiko, 高山 孝治, 寛島 佑史, 松本 知之, Kurosaka Masahiro, Kuroda Ryosuke

  Jul. 2014, JOSKAS, 39(4号) (4号), 238, Japanese

  [Refereed]

  Research society


• 膝前十字靱帯再建術における初期固定張力の関節内への伝達率の検討

  長井 寛斗, Kuroda Ryosuke, 星野 祐一, 西澤 勇一郎, 荒木 大輔, 中野 直樹, Matsushita Takehiko, 松本 知之, 高山 孝治, 長宗 高樹, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2014, JOSKAS, 39(4号) (4号), 371 - 371, Japanese

  [Refereed]

  Research society


• 単顆人工膝関節置換術の術後短期臨床成績 変形性膝関節症と特発性骨壊死症の比較検討

  寛島 佑史, 松本 知之, 高山 孝治, 壼坂 正徳, 佐々木 宏, 石田 一成, 柴沼 均, Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  Jul. 2014, JOSKAS, 39(4号) (4号), 156, Japanese

  [Refereed]

  Research society


• 単顆型人工膝関節置換術における術中gap計測はインサートサイズ選択の指標となる

  高山 孝治, 松本 知之, 村津 裕嗣, 中野 直樹, 上藤 淳郎, 長井 寛斗, 石田 一成, 柴沼 均, Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  Jul. 2014, JOSKAS, 39(4号) (4号), 157, Japanese

  [Refereed]

  Research society


• 関節外変形を伴う変形性膝関節症に対する人工膝関節全置換術の術後短期臨床成績 ナビゲーション使用群と従来群での比較

  谷 和泉, 松本 知之, 高山 孝治, 川上 洋平, 黒田 雄一, Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2014, JOSKAS, 39(4号) (4号), 441 - 441, Japanese

  [Refereed]

  Research society


• 外反型変形性膝関節症に対するLPS-Flexを用いた人工膝関節全置換術の術後短期臨床成績

  中野 直樹, 松本 知之, 村津 裕嗣, Matsushita Takehiko, 高山 孝治, 松崎 時夫, 上藤 淳郎, 長井 寛斗, Kuroda Ryosuke, Kurosaka Masahiro

  Jul. 2014, JOSKAS, 39(4号) (4号), 398, Japanese

  [Refereed]

  Research society


• ゼラチンハイドロゲルDDS技術を取り入れた骨・軟骨再生医療

  Kuroda Ryosuke, 松崎 時夫, Matsushita Takehiko, 松本 知之, Kurosaka Masahiro, 田畑 泰彦

  Jul. 2014, 日本DDS学会学術集会プログラム予稿集 30回, 84, Japanese

  [Refereed][Invited]

  Research society


• シンバスタチンのヒト半月板に対する有効性の検討

  張 樹蓉, Matsushita Takehiko, 松本 知之, 高山 孝治, 松崎 時夫, 岡 真也, 長井 寛斗, 上藤 淳郎, 中野 直樹, Kurosaka Masahiro, Kuroda Ryosuke

  Jul. 2014, JOSKAS, 39(4号) (4号), 353, Japanese

  Research society


• Tibial tuberosity-trochlear groove distance高値患者における内側膝蓋大腿靱帯再建術術後成績

  Matsushita Takehiko, Kuroda Ryosuke, 岡 真也, 松本 知之, 星野 祐一, 長井 寛斗, 西澤 勇一朗, 中野 直樹, 松崎 時夫, Kurosaka Masahiro

  Jul. 2014, JOSKAS, 39(4号) (4号), 137, Japanese

  [Refereed]

  Research society


• MDCTを用いた前十字靱帯解剖学的二重束再建術後骨孔拡大の検討

  荒木 大輔, Kuroda Ryosuke, 松本 知之, 長宗 高樹, Matsushita Takehiko, 高山 孝治, 西澤 勇一郎, 星野 祐一, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2014, JOSKAS, 39(4号) (4号), 391 - 391, Japanese

  Research society


• Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

  Tokio Matsuzaki, Takehiko Matsushita, Koji Takayama, Tomoyuki Matsumoto, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Jul. 2014, ANNALS OF THE RHEUMATIC DISEASES, 73(7) (7), 1397 - 1404, English

  [Refereed]

  Scientific journal


• CR-TKAにおける内側解離と脛骨内旋運動量の関係

  松本 知之, 高山 孝司, 石田 一成, 松崎 時夫, 中野 直樹, 上藤 淳郎, 長井 寛斗, 村津 裕嗣, Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  Jul. 2014, JOSKAS, 39(4号) (4号), 131, Japanese

  [Refereed]

  Research society


• ACL損傷に対する治療の現状と今後の戦略 膝前十字靱帯(ACL)損傷の術前・術後評価法

  Kuroda Ryosuke, Matsushita Takehiko, 星野 祐一, 荒木 大輔, 高山 孝治, 松本 知之, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2014, JOSKAS, 39(4号) (4号), 98 - 98, Japanese

  [Refereed][Invited]

  Research society


• Osteoarthritis: Molecular mechanisms and treatments

  Takehiko Matsushita, Ryosuke Kuroda

  Springer-Verlag London Ltd, Jun. 2014, Developing Insights in Cartilage Repair, 9781447153856, 65 - 77, English

  [Refereed]

  In book


• Complete traumatic backout of the blade of proximal femoral nail antirotation: A case report

  S. Y. Lee, T. Niikura, T. Iwakura, Y. Sakai, R. Kuroda, M. Kurosaka

  Jun. 2014, ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH, 100(4) (4), 441 - 443, English

  [Refereed]

  Scientific journal


• 股関節機能と片脚反復横跳び動作時の下肢関節角度および関節トルクの変化量との関係

  伊藤 浩充, 瀧口 耕平, 柴田 洋平, 木田 晃弘, 黒田 良祐, 黒坂 昌弘

  (公社)日本理学療法士協会, May 2014, 理学療法学, 41(大会特別号2) (大会特別号2), 0132 - 0132, Japanese


• 有症性の両側第4腓骨筋腱に対する治療経験

  鎮西 伸顕, Kanzaki Noriyuki, Hayashi Shinya, 木原 伸介, 酒井 良忠, 秋末 敏宏, Kuroda Ryosuke, Kurosaka Masahiro

  May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S308, Japanese

  [Refereed]

  Research society


• 膝前十字靱帯再建に対し同種腱移植を用いた1例

  壺坂 正徳, Kuroda Ryosuke, Matsushita Takehiko, 高山 孝治, 松本 知之, Kurosaka Masahiro

  May 2014, 移植, 49(1号) (1号), 180, Japanese

  [Refereed]

  Research society


• 人工膝関節再々置換術後に膝窩動脈閉塞を認めた1例

  辻本 龍, Matsumoto Tomoyuki, Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  May 2014, 中部日本整形外科災害外科学会雑誌, 57(3号) (3号), 515 - 516, Japanese

  [Refereed]

  Scientific journal


• 骨修復促進のストラテジー 細胞治療、低出力超音波パルスによる骨治癒促進

  Niikura Takahiro, 松本 知之, Kuroda Ryosuke, 李 相亮, 岩倉 崇, Kurosaka Masahiro

  May 2014, 日本骨形態計測学会雑誌, 24(2号) (2号), S60, Japanese

  Research society


• マウスiPS細胞由来骨前駆細胞はLIPUSにより骨分化が促進される

  奥町 悦子, 李 相亮, Niikura Takahiro, 岩倉 崇, 堂垣 佳宏, 脇 貴洋, 高原 俊介, Nishida Kotaro, Kuroda Ryosuke, Kurosaka Masahiro

  May 2014, 移植, 49(1号) (1号), 182, Japanese

  Research society


• G2ステム使用症例の短中期成績

  鎮西 伸顕, Hayashi Shinya, Kanzaki Noriyuki, 木原 伸介, 酒井 良忠, 秋末 敏宏, Kuroda Ryosuke, Kurosaka Masahiro

  May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S305, Japanese

  [Refereed]

  Research society


• Tactile Surgical Navigation System for Complex Acetabular Fracture Surgery

  Takahiro Niikura, Maki Sugimoto, Sang Yang Lee, Yoshitada Sakai, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Apr. 2014, ORTHOPEDICS, 37(4) (4), 223 - 228, English

  [Refereed]

  Scientific journal


• Tibial Tubercle Osteotomy With Screw Fixation for Total Knee Arthroplasty

  Nobuaki Chinzei, Kazunari Ishida, Ryosuke Kuroda, Tomoyuki Matsumoto, Seiji Kubo, Tetsuhiro Iguchi, Takaaki Chin, Toshihiro Akisue, Kotaro Nishida, Masahiro Kurosaka, Nobuhiro Tsumura

  Apr. 2014, ORTHOPEDICS, 37(4) (4), E367 - +, English

  [Refereed]

  Scientific journal


• アスリートにおける二次性変形性膝関節症の治療

  上藤 淳郎, Kuroda Ryosuke, Matsushita Takehiko, Matsumoto Tomoyuki, 岡 真也, 西澤 勇一郎, 松崎 時夫, 長井 寛斗, 中野 直樹, Kurosaka Masahiro

  Apr. 2014, JOSKAS, 39(2号) (2号), 416 - 417, Japanese

  [Refereed]

  Scientific journal


• Reduction of tunnel enlargement with use of autologous ruptured tissue in anterior cruciate ligament reconstruction: a pilot clinical trial.

  Tomoyuki Matsumoto, Ryosuke Kuroda, Takehiko Matsushita, Daisuke Araki, Yuichi Hoshino, Kouki Nagamune, Masahiro Kurosaka

  PURPOSE: To compare the tunnel enlargement of double-bundle (DB) anterior cruciate ligament reconstruction (ACLR) with and without suturing of autologous ruptured tissue to hamstring graft in patients with subacute anterior cruciate ligament injury. METHODS: Ten patients with subacute (≤3 months after injury) anterior cruciate ligament rupture were randomly allocated to undergo DB ACLR with suturing of the ruptured tissue to hamstring graft (n = 5) or conventional DB ACLR (n = 5). When autologous ruptured tissue was used, remnant ruptured tissue was then harvested, divided into 4 pieces, placed between the loops at the distal and proximal portions of the graft, and secured with the suture. As the primary endpoint, tunnel volume assessment by 3-dimensional multi-detector row computed tomography (MDCT) was performed 1 year after ACLR. To assess the efficacy of these procedures, the Lysholm score, anterior tibial translation (measured with a KT-1000 arthrometer [MEDmetric, San Diego, CA]), and rotational instability (measured by the pivot-shift test) were evaluated after 2 years. RESULTS: Tunnel volume enlargement between 3 weeks and 1 year after ACLR as assessed by 3-dimensional MDCT was significantly less for ACLR using ruptured tissue than for conventional ACLR, especially at the femoral site (P < .05). However, the postoperative Lysholm score, anterior stability of the knee measured with the KT-1000 arthrometer, and rate of negative manual pivot-shift test results did not differ significantly between the 2 groups. There was no correlation to the clinical outcomes in terms of tunnel size. CONCLUSIONS: The Lysholm score, anterior laxity measured with the KT-1000 arthrometer, and rotational instability according to the pivot-shift test did not differ significantly between ACLR using ruptured tissue and the conventional technique. However, ACLR using ruptured tissue produced less femoral tunnel enlargement as assessed by MDCT, warranting further long-term follow-up to elucidate its effectiveness. LEVEL OF EVIDENCE: Level II, prospective comparative study.

  Apr. 2014, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 30(4) (4), 468 - 74, English, International magazine

  [Refereed]

  Scientific journal


• A development of force distributionmeasurement system with high resolution for total knee arthroplasty

  Mohd Hanafi Mat Som, Kouki Nagamune, Takashi Kamiya, Shogo Kawaguchi, Koji Takayama, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2014, Journal of Advanced Computational Intelligence and Intelligent Informatics, 18(2) (2), 213 - 220

  Scientific journal


• Anatomy and biomechanics of medial patellofemoral ligament

  Shurong Zhang, Shinya Oka, Ryosuke Kuroda, Masahiro Kurosaka

  Springer-Verlag Berlin Heidelberg, Mar. 2014, The Patellofemoral Joint: State of the Art in Evaluation and Management, 17 - 22, English

  [Refereed]

  In book


• Satisfactory results at 8 years mean follow-up after ADVANCE (R) medial-pivot total knee arthroplasty

  Nobuaki Chinzei, Kazunari Ishida, Nobuhiro Tsumura, Tomoyuki Matsumoto, Atsushi Kitagawa, Tetsuhiro Iguchi, Kotaro Nishida, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2014, KNEE, 21(2) (2), 387 - 390, English

  [Refereed]

  Scientific journal


• No difference between double-high insert and medial-pivot insert in TKA

  Kazunari Ishida, Tomoyuki Matsumoto, Nobuhiro Tsumura, Takashi Iwakura, Seiji Kubo, Tetsuhiro Iguchi, Toshihiro Akisue, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda

  Mar. 2014, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 22(3) (3), 576 - 580, English

  [Refereed]

  Scientific journal


• A Rat Tail Temporary Static Compression Model Reproduces Different Stages of Intervertebral Disc Degeneration with Decreased Notochordal Cell Phenotype

  Hiroaki Hirata, Takashi Yurube, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Junya Yamamoto, Takuto Kurakawa, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka, Kotaro Nishida

  Mar. 2014, JOURNAL OF ORTHOPAEDIC RESEARCH, 32(3) (3), 455 - 463, English

  [Refereed]

  Scientific journal


• 靱帯バランス rectangular equal balanceを目指すべきか 定量的評価よりの提言

  松本 知之, 村津 裕嗣, 高山 孝治, 川上 洋平, 松崎 時夫, 中野 直樹, 長井 寛斗, 上藤 淳朗, 松下 雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(3号) (3号), S505 - S505, Japanese

  [Invited]

  Research society


• 膝蓋骨不安定症の病態と治療 内側膝蓋大腿靱帯再建術術後成績評価と成績に及ぼす因子の検討

  松下 雄彦, Kuroda Ryosuke, 岡 真也, 松本 知之, 西澤 勇一郎, 星野 祐一, 長井 寛斗, 松崎 時夫, 上藤 淳夫, 中野 直樹, Kurosaka Masahiro

  Mar. 2014, 日本整形外科学会雑誌, 88(2号) (2号), S343, Japanese

  [Refereed][Invited]

  Research society


• 単顆型人工膝関節置換術における術中gap kinematics計測とインサートサイズの相関

  高山 孝治, 松本 知之, 村津 裕嗣, 中野 直樹, 上藤 淳郎, 松崎 時夫, 岡 真也, 柴沼 均, 松下 雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2014, 日本整形外科学会雑誌, 88(3号) (3号), S620, Japanese

  [Refereed]

  Research society


• 足部インピンジメント症候群の診断と治療 足関節以外の足部インピンジメント症候群に対する足部内視鏡手術

  Kanzaki Noriyuki, 熊井 司, 田中 康仁, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(2号) (2号), S417 - S416, Japanese

  [Refereed]

  Research society


• 青壮年期の股関節痛への対応 Femoroacetabular impingementに対する画像診断

  橋本 慎吾, Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2014, 日本整形外科学会雑誌, 88(2号) (2号), S476, Japanese

  [Refereed]

  Research society


• 人工股関節再置換術の創意工夫 Kerboull型プレートを用いた人工股関節再置換術の術後成績

  Hayashi Shinya, Fujishiro Takaaki, Kanzaki Noriyuki, 橋本 慎吾, 西山 隆之, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2014, 日本整形外科学会雑誌, 88(2号) (2号), S463, Japanese

  [Refereed]

  Research society


• 人工股関節を適切な位置に設置するための術前・術後の評価 CT based fluoroscopic matching navigation systemを使用したTHAの大腿骨コンポーネント設置精度における検討

  Fujishiro Takaaki, Hayashi Shinya, Kanzaki Noriyuki, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2014, 日本整形外科学会雑誌, 88(2号) (2号), S473, Japanese

  Research society


• 徐放化抗癌剤抱合血管内皮前駆細胞を用いた新しい骨肉腫治療法の開発

  川上 洋平, 伊井 正明, 松本 知之, 秋末 敏宏, 浅原 孝之, 田畑 泰彦, 朝日 通雄, Kuroda Ryosuke, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(3号) (3号), S645 - S645, Japanese

  [Refereed]

  Research society


• 三次元電磁気センサーを用いた前十字靱帯損傷膝における遺残組織の関節制動性評価

  長井 寛斗, Kuroda Ryosuke, 荒木 大輔, 西澤 勇一郎, 松下 雄彦, 星野 祐一, 松本 知之, 高山 孝治, 長宗 高樹, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(3号) (3号), S1006 - S1006, Japanese

  [Refereed]

  Research society


• 混合性結合組織病患者に生じた両側同時膝蓋腱断裂の1例

  山裏 耕平, 松下 雄彦, Kuroda Ryosuke, 松本 知之, 高山 孝治, Kurosaka Masahiro

  Mar. 2014, 関西関節鏡・膝研究会プログラム・演題抄録 26回, 32, Japanese

  [Refereed]

  Research society


• 骨盤・下肢骨折における静脈血栓塞栓症と可溶性フィブリン複合体(SFMC)の関係

  李 相亮, Niikura Takahiro, 岩倉 崇, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2014, 日本整形外科学会雑誌, 88(3号) (3号), S570, Japanese

  Research society


• 骨軟骨と滑膜・変形性関節症 関節リウマチ滑膜細胞ではミトコンドリア転写因子A(TFAM)の発現が変形性関節症滑膜細胞に比べ低下している

  酒井 良忠, 三浦 靖史, 福田 康治, 前田 俊恒, 柴沼 均, Kuroda Ryosuke, Kurosaka Masahiro

  (一社)日本リウマチ学会, Mar. 2014, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 58回, 58回, 329 - 329, Japanese

  [Refereed]

  Research society


• 骨折治癒過程におけるmicroRNA発現の網羅的解析

  脇 貴洋, 李 相亮, Niikura Takahiro, 岩倉 崇, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2014, 中部日本整形外科災害外科学会雑誌, 57(春季学会) (春季学会), 124, Japanese

  Research society


• 血管内皮前駆細胞におけるSDF-1/CXCR4シグナルは骨折治癒において血管・骨新生を制御する

  川上 洋平, 伊井 正明, 松本 知之, 川本 篤彦, 美舩 泰, 黒田 知也, 庄司 太郎, 朝日 通雄, 浅原 孝之, Kuroda Ryosuke, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(2号) (2号), S458 - S458, Japanese

  [Refereed]

  Research society


• ヒト幹細胞承認後に実施されている臨床研究 偽関節患者を対象とした自家末梢血CD34陽性細胞移植による骨・血管再生療法

  Kuroda Ryosuke, Niikura Takahiro, 松本 知之, 李 相亮, 美舩 泰, Kurosaka Masahiro

  Mar. 2014, 日本整形外科学会雑誌, 88(2号) (2号), S460, Japanese

  Research society


• Tibial internal rotation is affected by lateral laxity in cruciate-retaining total knee arthroplasty: an intraoperative kinematic study using a navigation system and offset-type tensor

  Tokio Matsuzaki, Tomoyuki Matsumoto, Seiji Kubo, Hirotsugu Muratsu, Takehiko Matsushita, Yohei Kawakami, Kazunari Ishida, Shinya Oka, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2014, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 22(3) (3), 615 - 620, English

  [Refereed]

  Scientific journal


• Soft-tissue balancing in total knee arthroplasty: cruciate-retaining versus posterior-stabilised, and measured-resection versus gap technique

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Yohei Kawakami, Koji Takayama, Kazunari Ishida, Takehiko Matsushita, Toshihiro Akisue, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2014, INTERNATIONAL ORTHOPAEDICS, 38(3) (3), 531 - 537, English

  [Refereed]

  Scientific journal


• Soft tissue balance changes depending on joint distraction force in total knee arthroplasty

  Kanto Nagai, Hirotsugu Muratsu, Tomoyuki Matsumoto, Hidetoshi Miya, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2014, Journal of Arthroplasty, 29(3) (3), 520 - 524, English

  [Refereed]

  Scientific journal


• Matching Articular Surfaces of Selected Donor and Recipient Sites for Cylindrical Osteochondral Grafts of the Femur Quantitative Evaluation Using a 3-Dimensional Laser Scanner

  Yuichiro Nishizawa, Tomoyuki Matsumoto, Daisuke Araki, Kouki Nagamune, Takehiko Matsushita, Masahiro Kurosaka, Ryosuke Kuroda

  Mar. 2014, AMERICAN JOURNAL OF SPORTS MEDICINE, 42(3) (3), 658 - 664, English

  [Refereed]

  Scientific journal


• A rat tail temporary static compression model reproduces different stages of intervertebral disc degeneration with decreased notochordal cell phenotype.

  Hiroaki Hirata, Takashi Yurube, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Junya Yamamoto, Takuto Kurakawa, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka, Kotaro Nishida

  The intervertebral disc nucleus pulposus (NP) has two phenotypically distinct cell types-notochordal cells (NCs) and non-notochordal chondrocyte-like cells. In human discs, NCs are lost during adolescence, which is also when discs begin to show degenerative signs. However, little evidence exists regarding the link between NC disappearance and the pathogenesis of disc degeneration. To clarify this, a rat tail disc degeneration model induced by static compression at 1.3 MPa for 0, 1, or 7 days was designed and assessed for up to 56 postoperative days. Radiography, MRI, and histomorphology showed degenerative disc findings in response to the compression period. Immunofluorescence displayed that the number of DAPI-positive NP cells decreased with compression; particularly, the decrease was notable in larger, vacuolated, cytokeratin-8- and galectin-3-co-positive cells, identified as NCs. The proportion of TUNEL-positive cells, which predominantly comprised non-NCs, increased with compression. Quantitative PCR demonstrated isolated mRNA up-regulation of ADAMTS-5 in the 1-day loaded group and MMP-3 in the 7-day loaded group. Aggrecan-1 and collagen type 2α-1 mRNA levels were down-regulated in both groups. This rat tail temporary static compression model, which exhibits decreased NC phenotype, increased apoptotic cell death, and imbalanced catabolic and anabolic gene expression, reproduces different stages of intervertebral disc degeneration.

  Mar. 2014, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(3) (3), 455 - 63, English, International magazine

  [Refereed]

  Scientific journal


• 3D-MDCTを用いた前十字靱帯再建術後骨孔拡大の検討 解剖学的一重束再建術と二重束再建術との比較

  荒木 大輔, Kuroda Ryosuke, 松本 知之, 長宗 高樹, 松下 雄彦, 高山 孝治, 西澤 勇一郎, 星野 祐一, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(3号) (3号), S1001 - S1001, Japanese

  [Refereed]

  Research society


• An analysis of EndoButton displacement and attitude in anterior cruciate ligament reconstruction using bone tunnel axis

  Yosuke Uozumi, Kouki Nagamune, Naoki Nakano, Kanto Nagai, Yuichiro Nishizawa, Shinya Oka, Daisuke Araki, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Feb. 2014, 2014 Joint 7th International Conference on Soft Computing and Intelligent Systems, SCIS 2014 and 15th International Symposium on Advanced Intelligent Systems, ISIS 2014, 741 - 744

  [Refereed]

  International conference proceedings


• PTEN Regulates Matrix Synthesis in Adult Human Chondrocytes under Oxidative Stress

  Kenjiro Iwasa, Shinya Hayashi, Takaaki Fujishiro, Noriyuki Kanzaki, Shingo Hashimoto, Shuhei Sakata, Nobuaki Chinzei, Takayuki Nishiyama, Ryosuke Kuroda, Masahiro Kurosaka

  Feb. 2014, JOURNAL OF ORTHOPAEDIC RESEARCH, 32(2) (2), 231 - 237, English

  [Refereed]

  Scientific journal


• Notochordal cell disappearance and modes of apoptotic cell death in a rat tail static compression-induced disc degeneration model.

  Takashi Yurube, Hiroaki Hirata, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Zhongying Zhang, Koji Takayama, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka, Kotaro Nishida

  INTRODUCTION: The intervertebral disc has a complex structure originating developmentally from both the mesenchyme and notochord. Notochordal cells disappear during adolescence, which is also when human discs begin to show degenerative signs. During degeneration later in life, disc cells decline because of apoptosis. Although many animal models have been developed to simulate human disc degeneration, few studies have explored the long-term changes in cell population and phenotype. Our objective was to elucidate the time-dependent notochordal cell disappearance and apoptotic cell death in a rat tail static compression-induced disc degeneration model. METHODS: Twenty-four 12-week-old male Sprague-Dawley rat tails were instrumented with an Ilizarov-type device and loaded statically at 1.3 MPa for up to 56 days. Loaded and distal-unloaded discs were harvested. Changes in cell number and phenotype were assessed with histomorphology and immunofluorescence. Apoptosis involvement was determined with terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining and immunohistochemistry. RESULTS: The number of disc nucleus pulposus and annulus fibrosus cells decreased with the loading period; particularly, the decrease was notable at day 7 in larger, vacuolated, cytokeratin-8- and galectin-3-co-positive cells, indicating notochordal origin. Subsequently, the proportion of cells positive for TUNEL and cleaved caspase-3, markers of apoptosis induction, increased from day 7 through day 56. Although the percentage of cells immunopositive for cleaved caspase-8, a marker of apoptosis initiation through the death-receptor pathway, increased only at day 7, the percentage of cells immunopositive for cleaved caspase-9 and p53-regulated apoptosis-inducing protein 1 (p53AIP1), markers of apoptosis initiation through the p53-mediated mitochondrial pathway, increased from day 7 through day 56. The percentage of cells immunopositive for B-cell lymphoma 2 (Bcl-2) and silent mating type information regulation 2 homolog 1 (SIRT1), antiapoptotic proteins, decreased consistently with compression. CONCLUSIONS: This rat tail model mimics notochordal cell disappearance and apoptotic cell death in human disc aging and degeneration. Sustained static compression induces transient activation of apoptosis through the death-receptor pathway and persistent activation of apoptosis through the p53-mediated mitochondrial pathway in disc cells. The increased proapoptotic and decreased antiapoptotic proteins observed at all time points signify static compression-induced disc cell death and degeneration.

  Jan. 2014, Arthritis research & therapy, 16(1) (1), R31, English, International magazine

  [Refereed]


• Comparison of Force Concentration in Varus and Valgus Motion in Total Knee Arthroplasty

  Sahashi Katsuya, Kawaguchi Shogo, Som Mohd Hanafi Mat, Nagamune Kouki, Matsumoto Tomoyuki, Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  Total knee arthroplasty is a surgery to replace original injured knee to a prosthesis. In this surgery, it is important to select a proper size of the prosthesis as fitting to the patients. This selection strongly depends on the experience and feeling of surgeon. This study aims to develop a system which can support to select the proper size. Therefore, this study examines an effect of varus and valgus motion to the tibial component of the prosthesis by using the developed system. In general, when the force concentration happens on the tibial component, it results in wear of the prosthesis after surgery and can shorten lifetime of the prosthesis. This system can contribute to avoid these problems.

  Japan Society for Fuzzy Theory and Intelligent Informatics, 2014, Proceedings of the Fuzzy System Symposium, 30, 494 - 497, Japanese


• 前十字靱帯再建手術症例における筋力回復の経時的変化

  柴田 洋平, 黒田 良祐, 荒木 大輔, 木田 晃弘, 瀧口 耕平, 小野 くみ子, 西澤 勇一郎, 松下 雄彦, 松本 知之, 酒井 良忠, 黒坂 昌弘

  スポーツ傷害フォーラム, Jan. 2014, スポーツ傷害, 19, 46 - 46, Japanese


• Combined ACL and peripheral instability: The Eastern experience

  Ryosuke Kuroda, Takehiko Matsushita, Daisuke Araki, Yuichiro Nishizawa, Tomoyuki Matsumoto, Masahiro Kurosaka

  Springer-Verlag Milan, Jan. 2014, Knee Ligament Injuries: Extraarticular Surgical Techniques, 113 - 120, English

  [Refereed]

  In book


• Complete traumatic back-out of the blade of proximal femoral nail anti-rotation: A case report

  S. Y. Lee, T. Niikura, T. Iwakura, Y. Sakai, R. Kuroda, M. Kurosaka.

  Elsevier Masson SAS, 2014, Revue de Chirurgie Orthopedique et Traumatologique, 100(4) (4), 337, French

  [Refereed]

  Scientific journal


• Real-time 3D reconstruction of endoscopy and microfiber line laser

  Long Zhongjie, Kouki Nagamune, Xu Xiaoli, Daisuke Araki, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2014, PROCEEDINGS OF THE FIFTH INTERNATIONAL SYMPOSIUM ON TEST AUTOMATION & INSTRUMENTATION, VOLS 1 AND 2, 262 - 267, English

  [Refereed]

  International conference proceedings


• A Development of Force Distribution Measurement System Around Greater Trochanter Under Pelvic Belt

  Yusuke Shimizu, Kouki Nagamune, Kesuke Oe, Lee Sangyang, Takahiro Nikura, Ryosuke Kuroda, Masahiro Kurosaka

  2014, 2014 JOINT 7TH INTERNATIONAL CONFERENCE ON SOFT COMPUTING AND INTELLIGENT SYSTEMS (SCIS) AND 15TH INTERNATIONAL SYMPOSIUM ON ADVANCED INTELLIGENT SYSTEMS (ISIS), 745 - 748, English

  [Refereed]

  International conference proceedings


• An Evaluation of Bimodality on Quantitative Measurement System for Lachman Test Using Force Sensor

  Shogo Kawaguchi, Kouki Nagamune, Yuichiro Nishizavva, Daisuke Araki, Yuichi Hoshino, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2014, 2014 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN AND CYBERNETICS (SMC), 3936 - 3940, English

  [Refereed]

  International conference proceedings


• An Automated Determination of Blumensaat Line Using Fuzzy System Based on Physician Experience from Femur CT Image

  Yosuke Uozumi, Kouki Nagamune, Naoki Nakano, Kanto Nagai, Yuichiro Nishizawa, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2014, 2014 IEEE INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS (FUZZ-IEEE), 1831 - 1836, English

  [Refereed]

  International conference proceedings


• Comparison of Radiographic Appearance and Bone Scintigraphy in Fracture Nonunions

  Takahiro Niikura, Sang Yang Lee, Yoshitada Sakai, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2014, ORTHOPEDICS, 37(1) (1), E44 - E50, English

  [Refereed]

  Scientific journal


• MDCT Image Based Assessment of Acetabular Cup Orientation in Total Hip Arthroplasty

  Syoji Kobashi, Kenjiro Iwasa, Takaaki Fujishiro, Shiya Hayashi, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka, Naotake Kamiura

  2014, 2014 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN AND CYBERNETICS (SMC), 2014-January, 2557 - 2562, English

  International conference proceedings


• Retrospective comparison of three thromboprophylaxis agents, edoxaban, fondaparinux, and enoxaparin, for preventing venous thromboembolism in total knee arthroplasty

  Hiroshi Sasaki, Kazunari Ishida, Nao Shibanuma, Katsumasa Tei, Hiroomi Tateishi, Akihiko Toda, Yukiko Yamashiro, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka

  Springer Verlag, 2014, International Orthopaedics, 38(3) (3), 525 - 529, English

  [Refereed]

  Scientific journal


• Evaluation of patellofemoral joint in ADVANCE® Medial-pivot total knee arthroplasty

  Nobuaki Chinzei, Kazunari Ishida, Tomoyuki Matsumoto, Yuichi Kuroda, Atsushi Kitagawa, Ryosuke Kuroda, Toshihiro Akisue, Kotaro Nishida, Masahiro Kurosaka, Nobuhiro Tsumura

  Springer Verlag, 2014, International Orthopaedics, 38(3) (3), 509 - 515, English

  [Refereed]

  Scientific journal


• The influence of the tibial slope on intra-operative soft tissue balance in cruciate-retaining and posterior-stabilized total knee arthroplasty

  Shinya Oka, Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Takehiko Matsushita, Kazunari Ishida, Ryosuke Kuroda, Masahiro Kurosaka

  Springer Verlag, 2014, Knee Surgery, Sports Traumatology, Arthroscopy, 22(8) (8), 1812 - 1818, English

  [Refereed]

  Scientific journal


• Satisfactory results at 8years mean follow-up after ADVANCE® medial-pivot total knee arthroplasty

  Nobuaki Chinzei, Kazunari Ishida, Nobuhiro Tsumura, Tomoyuki Matsumoto, Atsushi Kitagawa, Tetsuhiro Iguchi, Kotaro Nishida, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka

  Elsevier, 2014, Knee, 21(2) (2), 387 - 390, English

  [Refereed]

  Scientific journal


• Missed massive morel-lavallee lesion

  Takahara S, Oe K, Fujita H, Sakurai A, Iwakura T, Lee Sangyang, Niikura Takahiro, Kuroda Ryosuke, Kurosaka Masahiro

  A Morel-Lavallee lesion (MLL) involves posttraumatic fluid collection around the greater trochanter. Many cases of MLL are missed at the initial evaluation, and the treatment of MLL is not well established. We present two cases in which MLL was missed at the initial evaluation. Case 1. A 65-year-old man was run over by a parade float. There was subcutaneous hematoma around the left greater trochanter, and no fracture was found. We diagnosed this injury as MLL on the 7th day after the trauma. Although we performed percutaneous drainage, the injured area was infected. Case 2. A 57-year-old man was hit by a train in a factory. There was an iliac wing fracture, but an MLL was not initially recognized. On the 6th day after the trauma, when performing open reduction and internal fixation for the iliac fracture, we recognized the lesion and performed percutaneous drainage simultaneously. This lesion also became infected. In these two cases, the wounds finally healed after a long duration of treatment. We suggest that it is important to keep this injury in mind and debride the lesion early and completely in the treatment course.

  2014, Case Rep Orthop, 2014, 920317 - 920317, English, International magazine

  [Refereed]

  Scientific journal


• Bicondylar hoffa fracture successfully treated with headless compression screws

  Lee Sangyang, Niikura Takahiro, Iwakura T, Sakai Yoshitada, Kuroda Ryosuke, Kurosaka Masahiro

  2014, Case Rep Orthop, 2014, 139897, English

  [Refereed]

  Scientific journal


• Arthroscopic ankle arthrodesis for treating osteoarthritis in a patient with kashin-beck disease

  Kenjiro Iwasa, Noriyuki Kanzaki, Takaaki Fujishiro, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka

  Hindawi Limited, 2014, Case Reports in Medicine, 2014, 931278, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Local Transplantation of Granulocyte Colony Stimulating Factor-Mobilized CD34(+) Cells for Patients With Femoral and Tibial Nonunion: Pilot Clinical Trial

  Ryosuke Kuroda, Tomoyuki Matsumoto, Takahiro Niikura, Yohei Kawakami, Tomoaki Fukui, Sang Yang Lee, Yutaka Mifune, Shin Kawamata, Masanori Fukushima, Takayuki Asahara, Atsuhiko Kawamoto, Masahiro Kurosaka

  Jan. 2014, STEM CELLS TRANSLATIONAL MEDICINE, 3(1) (1), 128 - 134, English

  [Refereed]

  Scientific journal


• Causative factors of fracture nonunion: the proportions of mechanical, biological, patient-dependent, and patient-independent factors

  Takahiro Niikura, Sang Yang Lee, Yoshitada Sakai, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2014, JOURNAL OF ORTHOPAEDIC SCIENCE, 19(1) (1), 120 - 124, English

  [Refereed]

  Scientific journal


• Flexible hinge silicone implant with or without titanium grommets for arthroplasty of the first metatarsophalangeal joint

  Noriyuki Kanzaki, Takayuki Nishiyama, Takaaki Fujishiro, Shinya Hayash, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka

  2014, JOURNAL OF ORTHOPAEDIC SURGERY, 22(1) (1), 42 - 45, English

  [Refereed]

  Scientific journal


• Age-related differences in anterior cruciate ligament remnant vascular-derived cells

  Atsuo Uefuji, Tomoyuki Matsumoto, Takehiko Matsushita, Takeshi Ueha, Shurong Zhang, Masahiro Kurosaka, Ryosuke Kuroda

  SAGE Publications Inc., 2014, American Journal of Sports Medicine, 42(6) (6), 1478 - 1486, English

  [Refereed]

  Scientific journal


• Treatment results of a periprosthetic femoral fracture case series: Treatment method for Vancouver type B2 fractures can be customized

  Takahiro Niikura, Sang Yang Lee, Yoshitada Sakai, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Korean Orthopaedic Association, 2014, Clinics in Orthopedic Surgery, 6(2) (2), 138 - 145, English

  [Refereed]

  Scientific journal


• Outcome of fixation for nonunion of extremities

  Takahiro Niikura, Sang Yang Lee, Yoshitada Sakai, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  2014, JOURNAL OF ORTHOPAEDIC SURGERY, 22(3) (3), 309 - 312, English

  [Refereed]

  Scientific journal


• Gentamycin-impregnated calcium phosphate cement for calcaneal osteomyelitis: a case report

  Takashi Iwakura, Sang Yang Lee, Takahiro Niikura, Masahiko Miwa, Yoshitada Sakai, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  2014, JOURNAL OF ORTHOPAEDIC SURGERY, 22(3) (3), 437 - 439, English

  [Refereed]

  Scientific journal


• Results of total knee arthroplasty with NexGen LPS-Flex for osteoarthritis in the valgus knee: a study of 26 patients followed for a minimum of 2 years

  Naoki Nakano, Tomoyuki Matsumoto, Hirotsugu Muratsu, Takehiko Matsushita, Koji Takayama, Tokio Matsuzaki, Ryosuke Kuroda, Masahiro Kurosaka

  Springer-Verlag France, 2014, European Journal of Orthopaedic Surgery and Traumatology, 25(2) (2), 375 - 380, English

  [Refereed]

  Scientific journal


• Influence of intra-operative parameters on postoperative early recovery of active knee flexion in posterior-stabilized total knee arthroplasty

  Kanto Nagai, Hirotsugu Muratsu, Tomoyuki Matsumoto, Akihiro Maruo, Hidetoshi Miya, Ryosuke Kuroda, Masahiro Kurosaka

  Nov. 2013, International Orthopaedics, 37(11) (11), 2153 - 2157

  [Refereed]

  Scientific journal


• 関節外変形を伴う症例に対しナビゲーションを併用してTKAを実施した7例の検討

  谷 和泉, 松本 知之, 松下 雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, Nov. 2013, 中部日本整形外科災害外科学会雑誌, 56(6号) (6号), 1347 - 1348, Japanese

  [Refereed]

  Research society


• Intraosseous Epidermoid Cyst in the Femur After an Open Fracture: A Case Report.

  Akisue T, Nishida K, Kishimoto K, Kawamoto T, Hara H, Hirata H, Kuroda R, Kurosaka M

  Oct. 2013, JBJS case connector, 3(4) (4), e120

  [Refereed]

  Scientific journal


• Long-term subjective outcomes of computer-assisted total knee arthroplasty

  Naoki Nakano, Tomoyuki Matsumoto, Kazunari Ishida, Nobuhiro Tsumura, Ryosuke Kuroda, Masahiro Kurosaka

  Oct. 2013, International Orthopaedics, 37(10) (10), 1911 - 1915, English

  [Refereed]

  Scientific journal


• Efficacy of hemostasis for epidural venous plexus and safety for neural structure using soft coagulation system in spinal surgery: a laboratory investigation using a porcine model.

  Kotaro Nishida, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Takashi Yurube, Ryosuke Kuroda, Masahiro Kurosaka

  STUDY DESIGN: A laboratory investigation using porcine model. OBJECTIVE: To clarify the effectiveness of the soft coagulation system for stopping bleeding from the epidural vein using different outputs and the safety in terms of tissue damage including spinal cord injury. SUMMARY OF BACKGROUND DATA: Problems associated with coagulation using an electrosurgical device, such as carbonization of tissue or adhesion to the electrode, have been highlighted. So called "soft coagulation" has been developed to solve these problems. Its' utility as well as the safety of the neural structure in spine surgery has never been reported. METHODS: A total of 3 animals and 45 spinal segments were used. Total laminectomy was performed to expose the dural tube and epidural venous plexus. Stable bleeding was induced by a 22 G needle puncture. Soft coagulation monopolar output (SCM), soft coagulation bipolar output (SCB), and conventional bipolar output (CB) were used as the coagulators. Valid hemostasis was defined as macroscopically complete bleeding stoppage by coagulation within 3 minutes. The neurological assessment was evaluated by somatosensory evoked potential. Histologic analysis was performed to determine the area of thermal damage. RESULTS: Valid hemostasis ratio was 75.0% of SCM group, 68.8% of SCB group, and 30.8% of CB group. Somatosensory evoked potential monitoring revealed that spinal cord injury was observed in 4 lesions (25%) of the SCM group. Neither bipolar groups (SCB and CB) showed any changes in waveform pattern. Histologic analysis revealed that severe thermal damages were observed in the epidural space of the SCM group. CONCLUSIONS: The usefulness of soft coagulation is revealed in terms of bleeding stoppage from epidural vessels and reduced soft-tissue damage compared with the conventional electric device. However, assessing the potential risk of severe neural tissue damage including spinal cord injury, a bipolar soft coagulation is strongly recommended for use in spine surgery.

  Oct. 2013, Journal of spinal disorders & techniques, 26(7) (7), E281-5 - 5, English, International magazine

  [Refereed]

  Scientific journal


• 有症性の両側第4腓骨筋腱に対する治療経験

  鎮西 伸顕, 神崎 至幸, Kuroda Ryosuke, Kurosaka Masahiro, 杜多 昭彦, 高倉 義幸, 高倉 義典

  Oct. 2013, 日本足の外科学会雑誌, 34(2号) (2号), S304, Japanese

  Research society


• 内側膝蓋大腿靱帯再建術後の膝伸展筋力の回復経過

  松下 雄彦, Kuroda Ryosuke, 柴田 洋平, 滝口 耕平, 松本 知之, 西澤 勇一郎, 長井 寛斗, 高山 孝治, 岡 真也, Kurosaka Masahiro

  (一社)日本臨床スポーツ医学会, Oct. 2013, 日本臨床スポーツ医学会誌, 21(4号) (4号), S244 - S244, Japanese

  Research society


• 当院での前十字靱帯再建手術症例における筋力回復の経時的変化

  柴田 洋平, Kuroda Ryosuke, 荒木 大輔, 瀧口 耕平, 西澤 勇一郎, 松下 雄彦, 松本 知之, 酒井 良忠, Kurosaka Masahiro

  (一社)日本臨床スポーツ医学会, Oct. 2013, 日本臨床スポーツ医学会誌, 21(4号) (4号), S144 - S144, Japanese

  Research society


• 競技レベルの高いスポーツ選手の膝半月板単独損傷に対する半月板縫合術の治療成績

  長井 寛斗, Kuroda Ryosuke, 松下 雄彦, 松本 知之, 星野 祐一, 岡 真也, 西澤 勇一郎, Kurosaka Masahiro

  (一社)日本臨床スポーツ医学会, Oct. 2013, 日本臨床スポーツ医学会誌, 21(4号) (4号), S242 - S242, Japanese

  Research society


• 距骨外側突起骨折後遺残変形に対する鏡視下手術

  坂田 周平, 神崎 至幸, 熊井 司, 田中 康仁, Fujishiro Takaaki, 杜多 昭彦, Kuroda Ryosuke, Kurosaka Masahiro

  Oct. 2013, 日本足の外科学会雑誌, 34(2号) (2号), S294, Japanese

  Research society


• 距骨に骨軟骨腫を生じた一例

  木原 伸介, 神崎 至幸, 秋末 敏弘, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke

  Oct. 2013, 日本足の外科学会雑誌, 34(2号) (2号), S278, Japanese

  Research society


• スポーツ愛好家の肩腱板大・広範囲断裂に対する鏡視下腱板修復術の検討

  Kokubu Takeshi, Kuroda Ryosuke, Kurosaka Masahiro

  Oct. 2013, 日本臨床スポーツ医学会誌, 21(4号) (4号), S207, Japanese

  Research society


• カシンベック病に伴う変形性足関節症に対し鏡視下足関節固定術をおこなった症例

  Fujishiro Takaaki, 神崎 至幸, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  Oct. 2013, 日本足の外科学会雑誌, 34(2号) (2号), S326, Japanese

  Research society


• TNK人工足関節置換術後の足関節可動域についての検討

  神崎 至幸, 高倉 義幸, 高倉 義典, 杜多 昭彦, 柴沼 均, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  Oct. 2013, 日本足の外科学会雑誌, 34(2号) (2号), S187, Japanese

  Research society


• Different pattern in gap balancing between the cruciate-retaining and posterior-stabilized total knee arthroplasty

  Tomoyuki Matsumoto, Seiji Kubo, Hirotsugu Muratsu, Takehiko Matsushita, Kazunari Ishida, Yohei Kawakami, Shinya Oka, Tokio Matsuzaki, Yuichi Kuroda, Kotaro Nishida, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka

  Oct. 2013, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 21(10) (10), 2338 - 2345, English

  [Refereed]

  Scientific journal


• A Bone Segmentation for the Knee Joint in MDCT Image Based on Anatomical Information

  Yosuke Uozumi, Kouki Nagamune, Daisuke Araki, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Sep. 2013, International Journal of Intelligent Computing in Medical Sciences and Image Processing, 5(2) (2), 105 - 113, English

  [Refereed]

  Scientific journal


• A small interfering RNA targeting Lnk accelerates bone fracture healing with early neovascularization

  Yohei Kawakami, Masaaki Li, Tomoyuki Matsumoto, Atsuhiko Kawamoto, Ryosuke Kuroda, Hiroshi Akimaru, Yutaka Mifune, Taro Shoji, Tomoaki Fukui, Michio Asahi, Masahiro Kurosaka, Takayuki Asahara

  Sep. 2013, Laboratory Investigation, 93(9) (9), 1036 - 1053, English

  [Refereed]

  Scientific journal


• 先端医療はどこまで進んだか 先端医療はどこまで進んだか? 運動器の損傷を再生医療で治す

  Kuroda Ryosuke

  Sep. 2013, 日本臨床内科医会会誌, 28(3号) (3号), 353, Japanese

  Research society


• 人工膝関節全置換術後深部感染50症例の治療成績 MRSA感染の影響

  松本 知之, 石田 一成, 津村 暢宏, 村津 裕嗣, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2013, 中部日本整形外科災害外科学会雑誌, 56(秋季学会) (秋季学会), 160, Japanese

  Research society


• 人工膝関節全置換術後の感染に対する複数回手術後に膝窩動脈閉塞を認めた1例

  辻本 龍, 松本 知之, 高山 孝治, 松下 雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2013, 中部日本整形外科災害外科学会雑誌, 56(5号) (5号), 1329, Japanese

  Research society


• 人工膝関節再々置換術後に膝窩動脈閉塞を認めた1例

  辻本 龍, 松本 知之, 高山 孝治, 松下 雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2013, 中部日本整形外科災害外科学会雑誌, 56(秋季学会) (秋季学会), 198, Japanese

  Research society


• An analysis of surface profile for cylindrical osteochondral grafts of the knee quantitative evaluation using a three-dimensional laser scanner

  Daisuke Araki, Ryosuke Kuroda, Tomoyuki Matsumoto, Kouki Nagamune, Takehiko Matsushita, Seiji Kubo, Yasunari Oniki, Masahiro Kurosaka

  Aug. 2013, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 21(8) (8), 1794 - 1800, English

  [Refereed]

  Scientific journal


• 膝前十字靱帯由来細胞の細胞特性における年齢による差異の検討

  上藤 淳郎, 松本 知之, 松下 雄彦, 川上 洋平, 岡 真也, 西澤 勇一郎, 松崎 時夫, 長井 寛斗, Kuroda Ryosuke, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2013, 日本整形外科学会雑誌, 87(8号) (8号), S1508 - S1508, Japanese

  Research society


• 軟骨変性の病態 長寿因子SIRT1による軟骨変性と変形性関節症における役割

  松下 雄彦, Kuroda Ryosuke, 松崎 時夫, 高山 孝治, 石田 一成, 佐々木 宏, 松本 知之, 藤田 周史, 長井 寛斗, Kurosaka Masahiro

  Aug. 2013, 日本整形外科学会雑誌, 87(8号) (8号), S1520, Japanese

  [Invited]

  Research society


• 前十字靱帯・内側側副靱帯・内側半月板損傷後復帰し得たロンドンオリンピックメダリストの一例 受傷から復帰まで

  荒木 大輔, Kuroda Ryosuke, 松田 直樹, 林 光俊, 山口 博, 藤田 耕司, 小原 和宏

  (一社)日本整形外科スポーツ医学会, Aug. 2013, 日本整形外科スポーツ医学会雑誌, 33(4号) (4号), 428 - 428, Japanese

  Research society


• 前十字靱帯(ACL)由来CD34陽性細胞による移植腱治癒促進のメカニズム-血管新生の効果

  高山 孝治, Mifune Yutaka, 松本 知之, 松下 雄彦, Kuroda Ryosuke, Kurosaka Masahiro, Wang Bing, Fu Freddie, Huard Johnny

  Aug. 2013, 日本整形外科学会雑誌, 87(8号) (8号), S1586, Japanese

  Research society


• 骨関節の再生医療の現状と展望 偽関節患者を対象とした、自家末梢血CD34陽性細胞を用いた骨・血管再生療法に関する第I・II相臨床試験

  松本 知之, Niikura Takahiro, 川上 洋平, 福井 友章, Mifune Yutaka, 李 相亮, 川本 篤彦, Kurosaka Masahiro, 浅原 孝之, Kuroda Ryosuke

  (公社)日本整形外科学会, Aug. 2013, 日本整形外科学会雑誌, 87(8号) (8号), S1545 - S1545, Japanese

  Research society


• マウス変形性関節症モデルにおける徐放化rapamycin投与の関節症進行抑制効果

  松崎 時夫, 松下 雄彦, 高山 孝治, 松本 知之, 岡 真也, 長井 寛斗, 上藤 淳郎, 齊藤 高志, 田畑 泰彦, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2013, 日本整形外科学会雑誌, 87(8号) (8号), S1605, Japanese

  Research society


• ヒト軟骨細胞における長寿遺伝子SIRT6による役割の検討

  長井 寛斗, 松下 雄彦, 松崎 時夫, 松本 知之, 張 樹蓉, 高山 孝治, 岡 真也, 西澤 勇一郎, 上藤 淳郎, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2013, 日本整形外科学会雑誌, 87(8号) (8号), S1359, Japanese

  Research society


• ヒト軟骨細胞においてPTENは酸化ストレス下に基質の産生を調整する

  岩佐 賢二郎, Hayashi Shinya, Fujishiro Takaaki, 神崎 至幸, 橋本 慎吾, 坂田 周平, 鎮西 伸顕, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2013, 日本整形外科学会雑誌, 87(8号) (8号), S1321, Japanese

  Research society


• エイコサペンタエン酸は酸化ストレス依存性の軟骨細胞の変性、アポトーシスを抑制する

  坂田 周平, Fujishiro Takaaki, Hayashi Shinya, 神崎 至幸, 橋本 慎吾, 岩佐 賢二郎, 鎮西 伸顕, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2013, 日本整形外科学会雑誌, 87(8号) (8号), S1322, Japanese

  Research society


• Reoxygenation using a novel CO2 therapy decreases the metastatic potential of osteosarcoma cells.

  Risa Harada, Teruya Kawamoto, Takeshi Ueha, Masaya Minoda, Mitsunori Toda, Yasuo Onishi, Naomasa Fukase, Hitomi Hara, Yoshitada Sakai, Masahiko Miwa, Ryosuke Kuroda, Masahiro Kurosaka, Toshihiro Akisue

  Osteosarcoma is the most common primary solid malignant bone tumor. Despite substantial improvements in surgery and chemotherapy, metastasis remains a major cause of fatal outcomes, and the molecular mechanisms of metastasis are still poorly understood. Hypoxia, which is common in malignant tumors including osteosarcoma, increases expressions of hypoxia inducible factor (HIF)-1α, matrix metalloproteinase (MMP)-2 and MMP-9, and can induce invasiveness. As we previously showed a novel transcutaneous CO2 application to decrease HIF-1α expression and induce apoptosis in malignant fibrous histiocytoma, we hypothesize that transcutaneous CO2 application could suppress metastatic potential of osteosarcoma by improving hypoxic conditions. Here, we examined the effects of transcutaneous CO2 application on apoptosis, and development of pulmonary metastasis using a highly metastatic osteosarcoma cell line, LM8. Transcutaneous CO2 application significantly decreased tumor growth and pulmonary metastasis in LM8 cells. Apoptotic activity increased, and intratumoral hypoxia was improved with decreased expressions of HIF-1α, MMP-2 and MMP-9, significantly, in the CO2-treated tumors. In conclusion, we found that transcutaneous CO2 application can induce tumor cell apoptosis and might suppress pulmonary metastasis by improvement of hypoxic conditions with decreased expressions of HIF-1α and MMPs in highly metastatic osteosarcoma cell. These findings strongly indicate that this novel transcutaneous CO2 therapy could be a therapeutic breakthrough for osteosarcoma patients.

  Aug. 2013, Experimental cell research, 319(13) (13), 1988 - 97, English, International magazine

  [Refereed]

  Scientific journal


• Effects of parathyroid hormone 1-34 on osteogenic and chondrogenic differentiation of human fracture haematoma-derived cells in vitro

  Dogaki Y, Lee SY, Niikura Takahiro, Koga T, Okumachi E, Nishida Kotaro, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2013, J Tissue Eng Regen Med, English

  [Refereed]

  Scientific journal


• ACL損傷の治療、復帰、評価 膝前十字靱帯再建術後評価 3次元電磁気センサーを用いた計測

  Kuroda Ryosuke, 荒木 大輔

  (一社)日本整形外科スポーツ医学会, Aug. 2013, 日本整形外科スポーツ医学会雑誌, 33(4号) (4号), 361 - 361, Japanese

  [Invited]

  Research society


• Tendon graft revitalization using adult anterior cruciate ligament (ACL)-derived CD34+ cell sheets for ACL reconstruction

  Yutaka Mifune, Tomoyuki Matsumoto, Koji Takayama, Satoshi Terada, Naosumi Sekiya, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H. Fu, Johnny Huard

  Jul. 2013, Biomaterials, 34(22) (22), 5476 - 5487, English

  [Refereed]

  Scientific journal


• Excessive femoral offset does not affect the range of motion after total hip arthroplasty

  Shinya Hayashi, Takayuki Nishiyama, Takaaki Fujishiro, Shingo Hashimoto, Noriyuki Kanzaki, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Jul. 2013, International Orthopaedics, 37(7) (7), 1233 - 1237, English

  [Refereed]

  Scientific journal


• レムナント温存2重束ACL再建術における移植腱再断裂の特徴

  山口 基, 佐々木 謙, 柏 薫里, 松本 彰生, 中山 寛, 吉矢 晋一, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4) (4), 344 - 344, Japanese


• 多血小板血漿(PRP)を用いたTKA施行患者の術後評価

  石田 一成, 森下 雅之, 柴沼 均, 鎮西 伸顕, 北川 篤, 松本 知之, 黒田 良祐, 黒坂 昌弘, 津村 暢宏

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4) (4), 561 - 561, Japanese


• 反復性膝蓋骨脱臼患者に対するMPFL再建術時の大腿骨再建位置シミュレーション

  岡 真也, Kuroda Ryosuke, 松下 雄彦, 多治見 寛之, 松本 知之, 西澤 勇一郎, 松崎 時夫, 上藤 淳郎, 長井 寛斗, Kurosaka Masahiro

  Jun. 2013, JOSKAS, 38(4号) (4号), 551, Japanese

  Research society


• 半月板損傷に対する治療法の現状と展望 半月板縫合術の治療成績

  Kuroda Ryosuke, 松下 雄彦, 長井 寛斗, 松本 知之, Kurosaka Masahiro

  Jun. 2013, JOSKAS, 38(4号) (4号), 117, Japanese

  [Invited]

  Research society


• 当科における前十字靱帯再建術時に半月板縫合術を行った症例の治療成績

  松下 雄彦, Kuroda Ryosuke, 長井 寛斗, 松本 知之, 星野 祐一, 岡 真也, 西澤 勇一郎, 松崎 時夫, 上藤 淳郎, Kurosaka Masahiro

  Jun. 2013, JOSKAS, 38(4号) (4号), 249, Japanese

  Research society


• 当科での膝半月板単独損傷に対する半月板縫合術の治療成績

  長井 寛斗, Kuroda Ryosuke, 松下 雄彦, 松本 知之, 星野 祐一, 岡 真也, 西澤 勇一郎, 松崎 時夫, 上藤 淳郎, Kurosaka Masahiro

  Jun. 2013, JOSKAS, 38(4号) (4号), 251, Japanese

  Research society


• 大腿骨・脛骨の関節外変形および対側THA後の高度外反膝に対してTKAを施行した1例

  向原 伸太郎, 松本 知之, 久保 晴司, 松下 雄彦, 川上 洋平, 谷 和泉, 黒田 雄一, Kuroda Ryosuke, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4号) (4号), 574 - 574, Japanese

  Research society


• 前十字靱帯再建術前後における膝最大伸展位での脛骨前方偏位の検討

  西澤 勇一郎, Kuroda Ryosuke, 松下 雄彦, 松本 知之, 川上 洋平, 岡 真也, 松崎 時夫, 上藤 淳郎, 長井 寛斗, 長宗 高樹, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4号) (4号), 175 - 175, Japanese

  Research society


• 前十字靱帯再建術を受けた壮年期患者の治療過程における不安について

  西村 実華, 高橋 奈那, Kuroda Ryosuke, 上杉 裕子

  Jun. 2013, 日本保健医療行動科学会学術大会プログラム・抄録集28回, 69, Japanese

  Research society


• 前十字靱帯(ACL)由来CD34陽性細胞による移植腱治癒促進の機序 血管新生の効果

  高山 孝治, Mifune Yutaka, 松本 知之, 松下 雄彦, Kuroda Ryosuke, Kurosaka Masahiro, Wang Bing, Fu Freddie, Huard Johnny

  Jun. 2013, JOSKAS, 38(4号) (4号), 159, Japanese

  Research society


• 人工膝単顆置換術の術中tensor計測において各関節引き離し力が術後屈曲角度に及ぼす影響

  松崎 時夫, 松本 知之, 村津 裕嗣, 鄭 克真, 松下 雄彦, 柴沼 均, 岡 真也, 長井 寛斗, 上藤 敦郎, Kuroda Ryosuke, Kurosaka Masahiro

  Jun. 2013, JOSKAS, 38(4号) (4号), 298, Japanese

  Research society


• 人工膝関節全置換術後感染例の治療成績 深部感染50症例の検討

  松本 知之, 石田 一成, 津村 暢宏, 村津 裕嗣, 飛田 祐一, 平中 崇文, 松下 雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4号) (4号), 460 - 460, Japanese

  Research society


• 人工膝関節全置換術における術中軟部組織バランスと膝蓋大腿関節接触圧の関係

  松本 知之, 柴沼 均, 川上 洋平, 村津 裕嗣, 岡 真也, 松崎 時夫, 松下 雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4号) (4号), 536 - 536, Japanese

  Research society


• カシンベック病に伴う変形性足関節症に対し鏡視下足関節固定術をおこなった症例

  神崎 至幸, 西山 隆之, Fujishiro Takaaki, Hayashi Shinya, 橋本 慎吾, Kuroda Ryosuke, Kurosaka Masahiro

  Jun. 2013, JOSKAS, 38(4号) (4号), 218, Japanese

  Research society


• アスリートにおける二次性変形性膝関節症の治療

  上藤 淳郎, Kuroda Ryosuke, 松下 雄彦, 松本 知之, 川上 洋平, 岡 真也, 西澤 勇一郎, 松崎 時夫, 長井 寛斗, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4号) (4号), 348 - 348, Japanese

  Research society


• Platelet-rich plasma protects rotator cuff-derived cells from the deleterious effects of triamcinolone acetonide

  Tomoyuki Muto, Takeshi Kokubu, Yutaka Mifune, Ryosuke Sakata, Issei Nagura, Hanako Nishimoto, Yoshifumi Harada, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2013, Journal of Orthopaedic Research, 31(6) (6), 976 - 982, English

  [Refereed]

  Scientific journal


• Evaluation of the accuracy of femoral component orientation by the CT-based fluoro-matched navigation system

  Shinya Hayashi, Takayuki Nishiyama, Takaaki Fujishiro, Shingo Hashimoto, Noriyuki Kanzaki, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2013, International Orthopaedics, 37(6) (6), 1063 - 1068, English

  [Refereed]

  Scientific journal


• Effect of Low-Intensity Pulsed Ultrasound on Bone Morphogenetic Protein 7-Induced Osteogenic Differentiation of Human Nonunion Tissue-Derived Cells In Vitro

  Takaaki Koga, Sang Yang Lee, Takahiro Niikura, Akihiro Koh, Yoshihiro Dogaki, Etsuko Okumachi, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2013, JOURNAL OF ULTRASOUND IN MEDICINE, 32(6) (6), 915 - 922, English

  [Refereed]

  Scientific journal


• Coxitis Kneeに対するTKAの経験

  黒田 雄一, 松本 知之, 向原 伸太郎, 川上 洋平, 松下 雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4号) (4号), 571 - 571, Japanese

  Research society


• Biomechanical Analysis of the Knee With Partial Anterior Cruciate Ligament Disruption: Quantitative Evaluation Using an Electromagnetic Measurement System

  Daisuke Araki, Ryosuke Kuroda, Takehiko Matsushita, Tomoyuki Matsumoto, Seiji Kubo, Kouki Nagamune, Masahiro Kurosaka

  Jun. 2013, ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 29(6) (6), 1053 - 1062, English

  [Refereed]

  Scientific journal


• Analysis of circulating mesenchymal progenitor cells in arterial and venous blood after fracture

  Takashi Iwakura, Sang Yang Lee, Masahiko Miwa, Yoshitada Sakai, Takahiro Niikura, Keisuke Oe, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2013, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 7(6) (6), 501 - 504, English

  [Refereed]

  Scientific journal


• ACL再建術one bundleからtwo bundle 同一施設でのoutcomeの比較 ACL再建術 ハムストリング腱を使用した一重束再建と二重束再建の比較

  Kuroda Ryosuke, 星野 祐一, 松下 雄彦, 松本 知之, Kurosaka Masahiro

  Jun. 2013, JOSKAS, 38(4号) (4号), 114, Japanese

  [Invited]

  Research society


• 大腿骨転子部骨折に対するshort femoral nail固定後にブレードが完全にback outした1例

  南埜 正五郎, 李 相亮, Niikura Takahiro, Kuroda Ryosuke, Kurosaka Masahiro

  May 2013, 中部日本整形外科災害外科学会雑誌, 56(3号) (3号), 772, Japanese

  Research society


• The reliability and validity of the Oxford Knee Score Japanese version in a prospective study

  UESUGI YUKO, 藤田 君支, 中村 宣雄, 柿本 明博, KURODA RYOSUKE, 菅野 伸彦

  日本運動器看護学会, May 2013, 日本運動器看護学会誌, Vol.8, 33 - 39, Japanese

  [Refereed]

  Scientific journal


• 偽関節患者を対象とした自家末梢血CD34陽性細胞移植による骨・血管再生療法 臨床試験の報告

  Niikura Takahiro, Kuroda Ryosuke, Matsumoto Tomoyuki, Lee Sangyang, 川上 洋平, Kurosaka Masahiro

  (一社)日本骨折治療学会, May 2013, 骨折, 35(2号) (2号), 465 - 468, Japanese

  [Refereed]

  Scientific journal


• Local Administration of Low-Dose Simvastatin-Conjugated Gelatin Hydrogel for Tendon-Bone Healing in Anterior Cruciate Ligament Reconstruction

  Shinya Oka, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Hiroshi Sasaki, Yuichiro Nishizawa, Tokio Matsuzaki, Takashi Saito, Kotaro Nishida, Yasuhiko Tabata, Masahiro Kurosaka, Ryosuke Kuroda

  May 2013, TISSUE ENGINEERING PART A, 19(9-10) (9-10), 1233 - 1243, English

  [Refereed]

  Scientific journal


• Kinematic factors affecting postoperative knee flexion after cruciate-retaining total knee arthroplasty

  Tokio Matsuzaki, Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Takehiko Matsushita, Yohei Kawakami, Kazunari Ishida, Shinya Oka, Ryosuke Kuroda, Masahiro Kurosaka

  May 2013, INTERNATIONAL ORTHOPAEDICS, 37(5) (5), 803 - 808, English

  [Refereed]

  Scientific journal


• In vitro hypertrophy and calcification of human fracture haematoma-derived cells in chondrogenic differentiation

  Takaaki Koga, Takahiro Niikura, Sang Yang Lee, Yoshihiro Dogaki, Etsuko Okumachi, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  May 2013, INTERNATIONAL ORTHOPAEDICS, 37(5) (5), 961 - 967, English

  [Refereed]

  Scientific journal


• The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes

  Takehiko Matsushita, Hiroshi Sasaki, Koji Takayama, Kazunari Ishida, Tomoyuki Matsumoto, Seiji Kubo, Tokio Matsuzaki, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda

  Apr. 2013, Journal of Orthopaedic Research, 31(4) (4), 531 - 537, English

  [Refereed]

  Scientific journal


• 未来への扉 膝 前十字靱帯部分損傷に対する術前、術後評価、補強術

  松下 雄彦, Kuroda Ryosuke, 西澤 勇一郎, 荒木 大輔, 松本 知之, 星野 祐一, 長井 寛斗, 松崎 時夫, 上藤 敦朗, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(3号) (3号), S531 - S224, Japanese

  [Invited]

  Research society


• 膝蓋大腿関節障害

  Kuroda Ryosuke, 松下 雄彦, 岡 真也, 松本 知之, Kurosaka Masahiro

  Mar. 2013, 日本整形外科学会雑誌, 87(3号) (3号), S571, Japanese

  [Invited]

  Research society


• 発泡スチロールビーズを使用した新開発インソールの、RA足部変形に対する効果

  酒井 良忠, 柱本 照, 岡野 隆一, 川崎 善子, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2013, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集57回・22回, 588, Japanese

  Research society


• 炭酸ガス経皮吸収は骨折治癒促進法となりうる

  古賀 敬章, Niikura Takahiro, 李 相亮, 堂垣 佳宏, 奥町 悦子, 上羽 岳志, 酒井 良忠, 大江 啓介, Kuroda Ryosuke, 三輪 雅彦, Kurosaka Masahiro

  Mar. 2013, 日本整形外科学会雑誌, 87(2号) (2号), S291, Japanese

  Research society


• 体外培養増幅ヒト骨髄由来CD34陽性細胞を用いた難治性骨折に対する新規治療法の開発

  川上 洋平, 伊井 正明, 松本 知之, 川本 篤彦, 庄司 太郎, Mifune Yutaka, 福井 友章, Kuroda Ryosuke, 浅原 孝之, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(2号) (2号), S289 - S289, Japanese

  Research society


• 前十字靱帯部分損傷に対する後外側線維束補強術の術後臨床成績

  松下 雄彦, Kuroda Ryosuke, 西澤 勇一郎, 松本 知之, 星野 祐一, 久保 晴司, 松崎 時夫, 長井 寛斗, 上藤 淳郎, Kurosaka Masahiro

  Mar. 2013, 日本整形外科学会雑誌, 87(2号) (2号), S467, Japanese

  Research society


• 前十字靱帯再建術前後における膝最大伸展位での脛骨前方偏位の検討

  Kuroda Ryosuke, Matsushita Takehiko, Matsumoto Tomoyuki, Kurosaka Masahiro

  関西関節鏡・膝研究会, Mar. 2013, 関西関節鏡・膝研究会プログラム・演題抄録25回, 25回, 26 - 26, Japanese

  [Refereed]

  Research society


• 正常ACL機能再現に向けての我々の再建術式 当科における解剖学的二重束ACL再建術及びACL補強術

  Matsushita Takehiko, Kuroda Ryosuke, Matsumoto Tomoyuki, Kurosaka Masahiro

  関西関節鏡・膝研究会, Mar. 2013, 関西関節鏡・膝研究会プログラム・演題抄録25回, 25回, 40 - 40, Japanese

  [Invited]

  Research society


• 細胞内アダプター蛋白Lnkの局所制御による早期の血管新生を通じた骨折治癒促進の可能性

  川上 洋平, 伊井 正明, 松本 知之, 川本 篤彦, Mifune Yutaka, 庄司 太郎, 福井 友章, 秋丸 裕司, Kuroda Ryosuke, 浅原 孝之, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(2号) (2号), S239 - S239, Japanese

  Research society


• 骨軟骨柱移植術におけるDonor siteとRecipient siteの軟骨表面形状の比較検討

  西澤 勇一郎, 松本 知之, 松下 雄彦, 長宗 高樹, Kurosaka Masahiro, Kuroda Ryosuke

  Mar. 2013, 中部日本整形外科災害外科学会雑誌, 56(春季学会) (春季学会), 147, Japanese

  Research society


• 血管内皮細胞におけるSDF-1/CXCR4シグナルは骨折治癒過程で血管・骨新生を制御する

  川上 洋平, 黒田 知也, 松本 知之, 伊井 正明, 川本 篤彦, Mifune Yutaka, 庄司 太郎, 福井 友章, Kuroda Ryosuke, 浅原 孝之, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(2号) (2号), S288 - S288, Japanese

  Research society


• 関節外変形を伴う膝OAに対しナビゲーションを併用してTKAを施行した7症例

  谷 和泉, 松本 知之, 川上 洋平, 松下 雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Mar. 2013, 中部日本整形外科災害外科学会雑誌, 56(春季学会) (春季学会), 214 - 214, Japanese

  Research society


• Tibial tuberosity-trochlear groove distanceのMPFL再建術術後成績へ及ぼす影響

  松下 雄彦, Kuroda Ryosuke, 岡 真也, 松本 知之, 久保 晴司, 西澤 勇一郎, 松崎 時夫, 上藤 淳郎, 長井 寛斗, Kurosaka Masahiro

  Mar. 2013, 日本整形外科学会雑誌, 87(3号) (3号), S885, Japanese

  Research society


• The influence of patella height on soft tissue balance in cruciate-retaining and posterior-stabilised total knee arthroplasty

  Yuichiro Nishizawa, Tomoyuki Matsumoto, Seiji Kubo, Hirotsugu Muratsu, Takehiko Matsushita, Shinya Oka, Kazunari Ishida, Tokio Matsuzaki, Kotaro Nishida, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2013, INTERNATIONAL ORTHOPAEDICS, 37(3) (3), 421 - 425, English

  [Refereed]

  Scientific journal


• Offset-type tensorによる人工膝関節全置換術における軟部組織バランス

  松本 知之, 村津 裕嗣, 松下 雄彦, 川上 洋平, Kuroda Ryosuke, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Mar. 2013, 中部日本整形外科災害外科学会雑誌, 56(春季学会) (春季学会), 212 - 212, Japanese

  Research society


• Medial patellofemoral ligament reconstruction with lateral soft tissue release in adult patients with habitual patellar dislocation

  Takehiko Matsushita, Ryosuke Kuroda, Daisuke Araki, Seiji Kubo, Tomoyuki Matsumoto, Masahiro Kurosaka

  Mar. 2013, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 21(3) (3), 726 - 730, English

  [Refereed]

  Scientific journal


• CT-free navigation systemを使用したTKAの中期臨床成績

  黒田 雄一, 松本 知之, 川上 洋平, 松下 雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Mar. 2013, 中部日本整形外科災害外科学会雑誌, 56(春季学会) (春季学会), 214 - 214, Japanese

  Research society


• CR型およびPS型人工膝関節全置換術における軟部組織バランス Measured resection techniqueとgap techniqueの比較

  松本 知之, 村津 裕嗣, 久保 晴司, 松下 雄彦, 川上 洋平, 岡 真也, 松崎 時夫, 長井 寛斗, Kuroda Ryosuke, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(2号) (2号), S488 - S488, Japanese

  Research society


• Therapeutic advantage in selective ligament augmentation for partial tears of the anterior cruciate ligament: results in an animal model.

  Yutaka Mifune, Shusuke Ota, Koji Takayama, Yuichi Hoshino, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H Fu, Johnny Huard

  BACKGROUND: As a result of recent studies describing the double-bundle anterior cruciate ligament (ACL), selected ACL augmentation procedures, either anteromedial (AM) or posterolateral (PL), have been introduced as the treatment of choice for partial ACL ruptures. The preserved mechanoreceptor and vascularity of the remnant ACL are considered to provide additional biological benefits. Although enhanced knee joint proprioception in ACL augmented patients has been previously reported, there is no study assessing biological healing advantages of the graft after the ACL augmentation procedure. HYPOTHESIS: Selected ACL augmentation for partial tears can accelerate the healing process of the grafted tendon, which promotes better biomechanical recovery of the tendon, compared with conventional ACL reconstruction of complete tears. STUDY DESIGN: Controlled laboratory study. METHODS: Two rat models were established in this study: an ACL augmentation partial tear model and conventional ACL reconstruction for a complete tear. Biological assessments of cellularity and angiogenesis were measured by hematoxylin and eosin staining and immunostaining, respectively. Additionally, rat-specific type III collagen and α-smooth muscle actin were evaluated by immunohistochemical staining to analyze the healing process, whereas anti-rat neurofilament antigen was assessed to examine proprioceptive recovery. Biological assessments of the augmented and reconstructed grafts were conducted postoperatively at week 2, whereas biomechanical testing was performed postoperatively at week 8. RESULTS: An increase in cellularity and angiogenesis was observed in the augmented grafts compared with the conventionally reconstructed grafts. Also, increased amounts of rat-specific type III collagen, α-smooth muscle actin, and anti-rat neurofilament antigen were expressed in the augmented grafts. Biomechanical testing showed that failure to load was significantly higher in the augmentation group compared with the conventional reconstruction group (augmentation, 15.9 ± 1.0; reconstruction, 7.0 ± 1.3; P < .01). CLINICAL RELEVANCE: Selected ACL augmentation could be a good choice for the repair of partial ACL injury by preserving the uninjured portion of the ACL, which in turn could maintain the anatomic position of the ligament and its biomechanical function.

  Feb. 2013, The American journal of sports medicine, 41(2) (2), 365 - 73, English, International magazine

  [Refereed]

  Scientific journal


• 下腿骨折における一時的創外固定の有用性と今後の課題

  李 相亮, Niikura Takahiro, 古賀 敬章, 堂垣 佳宏, 奥町 悦子, Kuroda Ryosuke, Kurosaka Masahiro

  Feb. 2013, 日本創外固定・骨延長学会雑誌, 24, 161, Japanese

  Research society


• Neurogenic bladder associated with pure cervical spondylotic myelopathy: clinical characteristics and recovery after surgery.

  Koji Fukuda, Takuma Ozaki, Nobuhiro Tsumura, Atsushi Sengoku, Masashi Nomi, Akihiro Yanagiuchi, Kotaro Nishida, Ryosuke Kuroda, Tetsuhiro Iguchi

  STUDY DESIGN: Retrospective study. OBJECTIVE: To examine the prevalence of lower urinary tract symptoms (LUTS) and neurogenic bladder (NB), and surgical outcomes in pure cervical spondylotic myelopathy. SUMMARY OF BACKGROUND DATA: The inclusion of various types of cervical diseases, NB, and no obvious definition of NB provided the wide range of NB prevalence frequency among previous reports. METHODS: Of the 220 operated patients with cervical myelopathy, 54 were selected by excluding other cervical and/or concomitant diseases contributing to LUTS. All patients with LUTS were referred to urologists and recommended to undergo urodynamic study (UDS). The presence of NB was judged by abnormal findings of UDS according to the most recent criteria and a congruity between LUTS and the course of cervical myelopathy. Patients were divided into 4 groups: no symptoms, positive symptoms without UDS examination, positive symptoms with positive NB, and positive symptoms with negative NB. Evaluation scores were compared among the groups before and after surgery. RESULTS: There were no particular LUTS in NB patients. Prevalence of LUTS was 53.7% and that of NB was at least 20.4% in the patients with pure cervical spondylotic myelopathy. The scores of all 4 groups improved after surgery (P < 0.05); however, the recovery rate of NB group (47.1%) was the worst among the groups (no-symptoms group, 69.3%; negative-NB group, 53.5%; and positive symptoms without UDS group, 57.1%). Preoperative part scores showed no difference among the groups, whereas NB group demonstrated lower scores in finger and lower extremity postoperatively. A post hoc analysis confirmed a significantly poorer recovery rate related to the NB group only in the lower extremities. CONCLUSION: This study is the first to describe the prevalence of LUTS and NB according to the most recent criteria in patients with pure cervical spondylotic myelopathy, which demonstrated that neurological functions in NB patients may recover; however, the extent will be limited to two-thirds of those in patients with no-NB; moreover, the remaining symptoms derive from poor lower limb function.

  Jan. 2013, Spine, 38(2) (2), 104 - 11, English, International magazine

  [Refereed]

  Scientific journal


• A Method of Mechanical Analysis of Lachman Test by Using Quantitative Measurement System With Force Sensor

  Kawaguchi Shogo, Nagamune Kouki, Nishizawa Yuichiro, Araki Daisuke, Hoshino Yuichi, Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  The anterior cruciate ligament (ACL) is one of strong ligaments in the knee. The ACL has a role to prevent excessive internal rotation and forwarding movement of the tibia. Lachman test is one of manual tests for examining the ACL. An examiner discriminates an injured degree of the ACL by feeling finger stress. Some measurement devices for Lachman test have been reported. However, these devices aim to analyze not the stress but the motion of the knee joint. Therefore, we set the goal of this study to develop a measurement system for the finger stress with force sensor during Lachman test. A quantitative measurement system during Lachman test with force sensor was developed. A basic experiment before numerical analysis of Endpoint revealed that the inclination of force can separate characteristics of string and elastic. Lachman test was measured by using this system on intra-examiner, inter-examiner and nonexpert. This result may indicate that this analysis method and the system have usefulness so that the bimodality or multi-modality were observed over half data. A future work is to apply the injured knees.

  Japan Society for Fuzzy Theory and Intelligent Informatics, 2013, Proceedings of the Fuzzy System Symposium, 29, 58 - 58, Japanese


• A Development of Force Distribution Measurement Systemin Total Knee Arthroplasty and reporting of the PS type measurement

  Kamiya Takashi, Kawaguchi Shogo, Som Mohd Hanafi Mat, Nagamune Kouki, Matsumoto Tomoyuki, Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  Currently, the number of Total Knee Arthroplasty (TKA) in Japan is 70,000. Because it is easy to expect increasing the number due to super-aging society, the clinical outcome of TKA surgery has been important. The surgery requires proper soft tissue balance to avoid shortening fatigue life of prosthesis. Thus, a measurement system of force concentration about contacting region between femur component and polyethylene insert contributes to prolong the prosthesis. This study examined the force concentration by using our developed measurement system. This study performed two experiment consists of physical and simulated experiment. As a result, our developed system could localize the force concentration point. A future work is to apply this measurement system to the cadaveric knee.

  Japan Society for Fuzzy Theory and Intelligent Informatics, 2013, Proceedings of the Fuzzy System Symposium, 29, 54 - 54, Japanese


• A surgery planning system by visualizing 3D profile of the knee during motion for anterior cruciate ligament reconstruction

  Kouki Nagamune, Yuichiro Nishizawa, Daisuke Araki, Koji Nishimoto, Yuichi Hoshino, Ryosuke Kuroda, Masahiro Kurosaka

  2013, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 8011(3) (3), 508 - 515, English

  [Refereed]

  International conference proceedings


• An Evaluation Method of Force Concentration in PS Type of Total Knee Arthroplasty with Force Distribution Measurement System

  Takashi Kamiya, Shogo Kawaguchi, Mohd Hanafi Mat Som, Kouki Nagamune, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka

  2013, 2013 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN, AND CYBERNETICS (SMC 2013), 2561 - 2564, English

  [Refereed]

  International conference proceedings


• An Evaluation System for Risk Factors of the Recurrent Patellar Subluxation : Position and Profile

  Akira Maki, Kouki Nagamune, Shinya Oka, Yuichiro Nishizawa, Daisuke Araki, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2013, 2013 INTERNATIONAL CONFERENCE ON SIGNAL-IMAGE TECHNOLOGY & INTERNET-BASED SYSTEMS (SITIS), 831 - 836, English

  [Refereed]

  International conference proceedings


• A Mechanical Analysis of Lachman Test Using a Quantitative Measurement System With Force Sensor

  Shogo Kawaguchi, Kouki Nagamune, Yuichiro Nishizawa, Shinya Oka, Daisuke Araki, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2013, 2013 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN, AND CYBERNETICS (SMC 2013), 2157 - 2162, English

  [Refereed]

  International conference proceedings


• An Early Development of Force Distribution Sensor Using Pressure-sensitive Conductive Rubber for Soft Tissue Balance in Total Knee Arthroplasty

  Mohd Hanafi Mat Som, Kouki Nagamune, Takashi Kamiya, Shogo Kawaguchi, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka

  2013, 2013 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN, AND CYBERNETICS (SMC 2013), 2556 - 2560, English

  [Refereed]

  International conference proceedings


• An automated analysis for anatomical structure of distal femur from MDCT image by contour tracing

  Yosuke Uozumi, Kouki Nagamune, Daisuke Araki, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  IEEE, 2013, Proceedings - 2013 International Conference on Signal-Image Technology and Internet-Based Systems, SITIS 2013, 842 - 847, English

  [Refereed]

  International conference proceedings


• Differences in knee kinematics between awake and anesthetized patients during the Lachman and pivot-shift Tests for anterior cruciate ligament deficiency

  Takehiko Matsushita, Shinya Oka, Kouki Nagamune, Tomoyuki Matsumoto, Yuichiro Nishizawa, Yuichi Hoshino, Seiji Kubo, Masahiro Kurosaka, Ryosuke Kuroda

  SAGE Publications Ltd, 2013, Orthopaedic Journal of Sports Medicine, 1(1) (1), 1 - 6, English

  [Refereed]

  Scientific journal


• Therapeutic superiority for cartilage repair by CD271-positive marrow stromal cell transplantation

  Yutaka Mifune, Tomoyuki Matsumoto, Satoshi Murasawa, Atsuhiko Kawamoto, Ryosuke Kuroda, Taro Shoji, Tomoya Kuroda, Tomoaki Fukui, Yohei Kawakami, Masahiro Kurosaka, Takayuki Asahara

  2013, Cell Transplantation, 22(7) (7), 1201 - 1211, English

  [Refereed]

  Scientific journal


• Sacral Fracture Nonunion Treated by Bone Grafting through a Posterior Approach

  Lee Sangyang, Niikura Takahiro, Sakai Yoshitada, Miwa M, Nishida Kotaro, Kuroda Ryosuke, Kurosaka Masahiro

  2013, Case Rep Orthop, 2013, 932521, English

  [Refereed]

  Scientific journal


• Nonunion with breakage of gamma nail and subsequent fracture in the ipsilateral femur

  Takahiro Niikura, Sang Yang Lee, Yoshitada Sakai, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Hindawi Limited, 2013, Case Reports in Medicine, 2013, 534570, English

  [Refereed]

  Scientific journal


• Breakage of a third generation gamma nail: a case report and review of the literature

  Iwakura T, Niikura Takahiro, Lee Sangyang, Sakai Yoshitada, Nishida Kotaro, Kuroda Ryosuke, Kurosaka Masahiro

  2013, Case Rep Orthop, 2013, 172352, English

  [Refereed]

  Scientific journal


• 両側内側膝蓋大腿靱帯(MPFL)再建術を施行したハイレベルスポーツ選手の2例

  黒田 雄一, Kuroda Ryosuke, 松下 雄彦, 松本 知之, 川上 洋平, Kurosaka Masahiro

  スポーツ傷害フォーラム, Jan. 2013, スポーツ傷害, 18, 43 - 43, Japanese

  [Refereed]

  Research society


• ソフトボールによる舟状骨骨折後に変形性楔舟関節症をきたした一例

  神崎 至幸, 熊井 司, 田中 康仁, 谷口 晃, 松田 剛典, Kuroda Ryosuke, Kurosaka Masahiro

  Jan. 2013, スポーツ傷害, 18, 1 - 4, Japanese

  [Refereed]

  Scientific journal


• Leg Edema Due to a Mass in the Pelvis After a Large-Diameter Metal-On-Metal Total Hip Arthroplasty

  Kohei Kawakita, Nao Shibanuma, Katsumasa Tei, Takayuki Nishiyama, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2013, Journal of Arthroplasty, 28(1) (1), 197 - e4, English

  [Refereed]

  Scientific journal


• Intra-operative joint gap kinematics in unicompartmental knee arthroplasty

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2013, CLINICAL BIOMECHANICS, 28(1) (1), 29 - 33, English

  [Refereed]

  Scientific journal


• Novel image-matching software for postoperative evaluation after TKA.

  Tei K, Ishida K, Matsumoto T, Kubo S, Sasaki H, Shibanuma N, Akisue T, Nishida K, Kurosaka M, Kuroda R

  Although 2-dimensional assessments using postoperative plain radiographs have been used after total knee arthroplasty (TKA) in previous studies, a strong possibility exists that deviation can occur when assessing 3-dimensional (3-D) objects. The purpose of this study was to test the hypothesis that novel 3-D image-matching software could accurately assess the positioning of implants and could be a useful tool in postoperative evaluation after TKA.Total knee arthroplasty was performed in 30 consecutive patients. Intraoperatively, the thickness of each bone cut was measured. Postoperatively, the thickness of each part of the bone cut was measured using Athena Knee (SoftCube Co, Ltd, Osaka, Japan) 3-D image-matching software. The results revealed no significant differences in the medial compartment and significant differences of approximately 1 mm in the lateral compartment. The difference was possibly caused by the remaining cartilage in the lateral compartment. Linear regression analysis revealed a statistically excellent correlation between intra- and postoperative values in all parts of the bone cuts. Although the 3-D image-matching software used in this study was originally developed for preoperative planning in TKA, it is considered accurate enough to assess the positioning of implants with respect to the bone after TKA.

  Dec. 2012, Orthopedics, 35(12) (12), e1711 - 5, English, International magazine

  [Refereed]

  Scientific journal


• 自家末梢血CD34陽性細胞による難治性骨折の治療

  Kuroda Ryosuke, Niikura Takahiro, Matsumoto Tomoyuki, Lee Sangyang, Mifune Yutaka, Kurosaka Masahiro

  (一社)日本移植学会, Dec. 2012, 移植, 47(6号) (6号), 497 - 498, Japanese

  [Refereed]

  Research society


• Regeneration of Rotator Cuff Tear Using Electrospun Poly(D,L-Lactide-Co-Glycolide) Scaffolds in a Rabbit Model

  Atsuyuki Inui, Takeshi Kokubu, Yutaka Mifune, Ryosuke Sakata, Hanako Nishimoto, Kotaro Nishida, Toshihiro Akisue, Ryosuke Kuroda, Makoto Satake, Hiroaki Kaneko, Hiroyuki Fujioka

  Dec. 2012, ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 28(12) (12), 1790 - 1799, English

  [Refereed]

  Scientific journal


• iPS細胞の骨再生へ向けた新たな骨分化誘導法の確立

  Lee Sangyang, Niikura Takahiro, Kakutani Junichiro, Akisue Toshihiro, Nishida Kotaro, Kuroda Ryosuke, Kurosaka Masahiro

  Dec. 2012, 移植, 47(6号) (6号), 498 - 499, Japanese

  [Refereed]

  Symposium


• Akt phosphorylation in human chondrocytes is regulated by p53R2 in response to mechanical stress

  K. Kawakita, T. Nishiyama, T. Fujishiro, S. Hayashi, N. Kanzaki, S. Hashimoto, K. Takebe, K. Iwasa, S. Sakata, K. Nishida, R. Kuroda, M. Kurosaka

  Dec. 2012, OSTEOARTHRITIS AND CARTILAGE, 20(12) (12), 1603 - 1609, English

  [Refereed]

  Scientific journal


• The influence of patella height on intra-operative soft tissue balance in posterior-stabilized total knee arthroplasty

  Hiroshi Sasaki, Seiji Kubo, Tomoyuki Matsumoto, Hirotsugu Muratsu, Takehiko Matsushita, Kazunari Ishida, Koji Takayama, Shinya Oka, Masahiro Kurosaka, Ryosuke Kuroda

  Nov. 2012, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 20(11) (11), 2191 - 2196, English

  [Refereed]

  Scientific journal


• Osteochondral autograft transplantation for juvenile osteochondritis dissecans of the knee: a series of twelve cases

  Ken Sasaki, Tomoyuki Matsumoto, Takehiko Matsushita, Seiji Kubo, Kazunari Ishida, Katsumasa Tei, Toshihiro Akisue, Masahiro Kurosaka, Ryosuke Kuroda

  Nov. 2012, INTERNATIONAL ORTHOPAEDICS, 36(11) (11), 2243 - 2248, English

  [Refereed]

  Scientific journal


• Multiple huge subchondral cysts associated with pseudogout in the bilateral knees: a case report and review of the literatures

  Masaya Minoda, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Koji Takayama, Yukiko Morinaga, Masahiro Kurosaka, Ryosuke Kuroda

  Nov. 2012, JOURNAL OF ORTHOPAEDIC SCIENCE, 17(6) (6), 817 - 821, English

  [Refereed]

  Scientific journal


• Grade three disc degeneration is a critical stage for anterior spondylolisthesis in lumbar spine

  Tetsuhiro Iguchi, Kotaro Nishida, Takuma Ozaki, Atsushi Kitagawa, Nobuhiro Tsumura, Kenichiro Kakutani, Takashi Yurube, Ryosuke Kuroda

  Nov. 2012, EUROPEAN SPINE JOURNAL, 21(11) (11), 2134 - 2139, English

  [Refereed]

  Scientific journal


• レムナントを温存した2重束ACL再建術の再受傷について

  山口 基, 佐々木 謙, 柏 薫里, 松本 彰生, 中山 寛, 吉矢 晋一, 黒田 良祐, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2012, 日本臨床スポーツ医学会誌, 20(4) (4), S212 - S212, Japanese


• 【骨・関節のバイオメカニクス-最近の進歩】電磁気センサーを用いた前十字靱帯再建術前後の膝安定性評価

  星野 祐一, 黒田 良祐, 荒木 大輔, 松下 雄彦, 長宗 高樹, 黒坂 昌弘

  金原出版(株), Oct. 2012, 整形・災害外科, 55(11) (11), 1383 - 1389, Japanese


• In vivo comparisons of patellofemoral kinematics before and after ADVANCE® Medial-Pivot total knee arthroplasty

  Kazunari Ishida, Tomoyuki Matsumoto, Nobuhiro Tsumura, Nobuaki Chinzei, Atsushi Kitagawa, Seiji Kubo, Takaaki Chin, Tetsuhiro Iguchi, Toshihiro Akisue, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda

  Oct. 2012, International Orthopaedics, 36(10) (10), 2073 - 2077, English

  [Refereed]

  International conference proceedings


• 両側高位脛骨骨切り術を施行しラグビーに復帰した高齢者の1例

  Kuroda Ryosuke, Matsushita Takehiko, Matsumoto Tomoyuki, Kurosaka Masahiro

  Oct. 2012, 日本臨床スポーツ医学会誌, 20(4号) (4号), S183, Japanese

  [Refereed]

  Research society


• 軟骨エイジング そのメカニズムと評価 長寿因子SIRT1の軟骨細胞における役割

  Matsushita Takehiko, Kuroda Ryosuke, Matsumoto Tomoyuki, Kurosaka Masahiro

  Oct. 2012, 日本関節病学会誌, 31(3号) (3号), 349, Japanese

  Research society


• 前十字靱帯部分損傷に対する後外側線維束補強術の術後臨床成績

  Matsushita Takehiko, Kuroda Ryosuke, Kubo Seiji, Matsumoto Tomoyuki, Kurosaka Masahiro

  Oct. 2012, 日本臨床スポーツ医学会誌, 20(4号) (4号), S209, Japanese

  [Refereed]

  Research society


• 前十字靱帯損傷膝における三次元電磁気センサーを用いたPivot shift testの定量的評価

  Kuroda Ryosuke, Matsushita Takehiko, Kubo Seiji, Matsumoto Tomoyuki, Nagamune Kouki, Kurosaka Masahiro

  Oct. 2012, 日本臨床スポーツ医学会誌, 20(4号) (4号), S211, Japanese

  [Refereed]

  Research society


• 三次元電磁気センサーを用いた膝前十字靱帯再建術による機能改善の定量的評価

  Kuroda Ryosuke, Matsushita Takehiko, Kubo Seiji, Matsumoto Tomoyuki, Nagamune Kouki, Kurosaka Masahiro

  Oct. 2012, 日本臨床スポーツ医学会誌, 20(4号) (4号), S211, Japanese

  [Refereed]

  Research society


• Intraoperative Soft Tissue Balance Reflects Minimum 5-Year Midterm Outcomes in Cruciate-Retaining and Posterior-Stabilized Total Knee Arthroplasty

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Takehiko Matsushita, Masahiro Kurosaka, Ryosuke Kuroda

  Oct. 2012, JOURNAL OF ARTHROPLASTY, 27(9) (9), 1723 - 1730, English

  [Refereed]

  Scientific journal


• Incidence of Venous Thromboembolism in Fractures Around and Below the Knee With Physical Prophylaxis

  Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Akihiro Koh, Takaaki Koga, Yoshihiro Dogaki, Etsuko Okumachi, Yoshitada Sakai, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka

  Oct. 2012, ORTHOPEDICS, 35(10) (10), E1476 - E1482, English

  [Refereed]

  Scientific journal


• 不安定型骨盤輪骨折に対する新しい創外固定方法の検討(第1報)

  大江 啓介, 長宗 高樹, 新倉 隆宏, 李 相亮, 黒田 良祐, 黒坂 昌弘

  (一社)日本骨折治療学会, Sep. 2012, 骨折, 34(3) (3), 536 - 538, Japanese

  [Refereed]


• 両側血友病性膝関節症に対して全人工膝関節置換術を施行した1例

  Kuroda Ryosuke, Kubo Seiji, Matsumoto Tomoyuki, Matsushita Takehiko, Nishida Kotaro, Kurosaka Masahiro

  Sep. 2012, 関節外科, 31(9号) (9号), 1045 - 1051, Japanese

  [Refereed]

  Scientific journal


• 当科で施行した膝前十字靱帯再々建術の検討

  Kuroda Ryosuke, Matsushita Takehiko, Kubo Seiji, Matsumoto Tomoyuki, Kurosaka Masahiro

  Sep. 2012, 中部日本整形外科災害外科学会雑誌, 55(秋季学会) (秋季学会), 127, Japanese

  [Refereed]

  Research society


• 【次世代治療を支えるDDS技術】 整形外科のためのDDS技術

  Kuroda Ryosuke

  日本DDS学会, Sep. 2012, Drug Delivery System, 27(4号) (4号), 283 - 288, Japanese

  Research society


• Spontaneous recurrent hemarthrosis of the knee joint in the elderly: A report of two cases

  Kanto Nagai, Tomoyuki Matsumoto, Takehiko Matsushita, Seiji Kubo, Koji Takayama, Daisuke Araki, Hiroshi Sasaki, Shinya Oka, Toshihiro Akisue, Masahiro Kurosaka, Ryosuke Kuroda

  Sep. 2012, Journal of Orthopaedic Science, 17(5) (5), 649 - 653, English

  [Refereed]

  Scientific journal


• PS型TKAにおけるtibial slopeおよびposterior condylar offsetが術中軟部組織バランスに及ぼす影響

  Matsumoto Tomoyuki, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2012, 中部日本整形外科災害外科学会雑誌, 55(秋季学会) (秋季学会), 74, Japanese

  [Refereed]

  Research society


• The accuracy of bone tunnel position using fluoroscopic-based navigation system in anterior cruciate ligament reconstruction

  Yohei Kawakami, Takafumi Hiranaka, Tomoyuki Matsumoto, Yuichi Hida, Tomoaki Fukui, Harunobu Uemoto, Minoru Doita, Mitsuo Tsuji, Masahiro Kurosaka, Ryosuke Kuroda

  Aug. 2012, Knee Surgery, Sports Traumatology, Arthroscopy, 20(8) (8), 1503 - 1510, English

  [Refereed]

  Scientific journal


• 膝前十字靱帯再建術の現状と課題 膝前十字靱帯(ACL)再建術の現状と課題 電磁気センサーを用いた徒手検査の定量評価

  Kuroda Ryosuke

  Aug. 2012, 日本整形外科スポーツ医学会雑誌, 32(4号) (4号), 469, Japanese

  Research society


• 軟骨細胞特異的Sirt1ノックアウトマウスにおける変形性関節症モデルを用いた解析

  Matsushita Takehiko, Matsumoto Tomoyuki, Kubo Seiji, Kurosaka Masahiro, Kuroda Ryosuke

  Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1272, Japanese

  [Refereed]

  Research society


• 軟骨再生の今 軟骨変性に対する長寿因子SIRT1を介した抑制制御機構

  Matsushita Takehiko, Kuroda Ryosuke, Matsumoto Tomoyuki, Kubo Seiji, Kurosaka Masahiro

  Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1248, Japanese

  Research society


• 低出力超音波パルスはBMP-7によるヒト偽関節組織由来細胞の骨分化を促進する

  Lee Sangyang, Niikura Takahiro, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1190, Japanese

  Research society


• 炭酸ガス経皮吸収はラットの骨折治癒を促進する

  Niikura Takahiro, Lee Sangyang, Sakai Yoshitada, Kuroda Ryosuke, Miwa Masahiko, Kurosaka Masahiro

  Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1232, Japanese

  [Refereed]

  Research society


• 炭酸ガス経皮吸収が運動後のラットの筋肉に及ぼす影響について

  Sakai Yoshitada, Niikura Takahiro, Lee Sangyang, Miwa Masahiko, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1268, Japanese

  Research society


• 体外培養増幅ヒト骨髄由来CD34陽性細胞の局所投与は骨折治癒を促進する

  Matsumoto Tomoyuki, Kuroda Ryosuke, Mifune Yutaka, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1059 - S1059, Japanese

  [Refereed]

  Research society


• 骨軟骨柱移植術におけるdonor siteとrecipient siteの軟骨表面形状の比較検討

  Matsumoto Tomoyuki, Matsushita Takehiko, Nagamune Kouki, Kubo Seiji, Kurosaka Masahiro, Kuroda Ryosuke

  Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1220, Japanese

  Research society


• 骨折治癒過程におけるSDF-1/CXCR4シグナルを介した血管内皮前駆細胞による血管・骨新生の制御

  Matsumoto Tomoyuki, Mifune Yutaka, Kuroda Ryosuke, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1059 - S1059, Japanese

  [Refereed]

  Research society


• 筋損傷を科学する 炭酸ガス経皮吸収の筋肉への効果

  Sakai Yoshitada, Miwa Masahiko, Niikura Takahiro, Lee Sangyang, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1225, Japanese

  Research society


• ヒト軟骨細胞においてPTENはtype II collagenの発現を制御する

  Nishiyama Takayuki, Hayashi Shinya, Fujishiro Takaaki, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1332, Japanese

  [Refereed]

  Research society


• アテロコラーゲンを用いた細胞内アダプター蛋白Lnkの局所制御による血管・骨新生促進を介した骨折治療法

  Matsumoto Tomoyuki, Kuroda Ryosuke, Mifune Yutaka, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1058 - S1058, Japanese

  [Refereed]

  Research society


• Simvastatin局所徐放による前十字靱帯再建術後の移植腱-骨孔間の成熟促進効果について

  Matsumoto Tomoyuki, Kubo Seiji, Matsushita Takehiko, Kurosaka Masahiro, Kuroda Ryosuke

  Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1323, Japanese

  [Refereed]

  Research society


• Backout of the Helical Blade of Proximal Femoral Nail Antirotation and Accompanying Fracture Nonunion

  Takahiro Niikura, Sang Yang Lee, Tomoyuki Matsumoto, Tomoaki Fukui, Yohei Kawakami, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka

  Aug. 2012, ORTHOPEDICS, 35(8) (8), E1264 - E1266, English

  [Refereed]

  Scientific journal


• A tale of 10 European centres - 2010 APOSSM travelling fellowship review in ACL surgery

  Yee Han D. Lee, Ryosuke Kuroda, Jinzhong Zhao, Kai M. Chan

  Jul. 2012, Sports Medicine, Arthroscopy, Rehabilitation, Therapy and Technology, 4(1) (1), English

  [Refereed]

  Scientific journal


• Optimal measurement of clinical rotational test for evaluating anterior cruciate ligament insufficiency

  Yuichi Hoshino, Ryosuke Kuroda, Kouki Nagamune, Daisuke Araki, Seiji Kubo, Motoi Yamaguchi, Masahiro Kurosaka

  Jul. 2012, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 20(7) (7), 1323 - 1330, English

  [Refereed]

  Scientific journal


• A preliminary study of the T1rho values of normal knee cartilage using 3 T-MRI

  Hajimu Goto, Yuki Iwama, Masahiko Fujii, Nobukazu Aoyama, Seiji Kubo, Ryosuke Kuroda, Yoshiharu Ohno, Kazuro Sugimura

  Jul. 2012, EUROPEAN JOURNAL OF RADIOLOGY, 81(7) (7), E796 - E803, English

  [Refereed]

  Scientific journal


• レムナントを温存した2重束ACL再建術の臨床成績

  山口 基, 佐々木 謙, 柏 薫里, 中山 寛, 吉矢 晋一, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2012, JOSKAS, 37(4) (4), 75 - 75, Japanese


• 当科における骨端線閉鎖前の患者に対するRetroDrillを用いた前十字靱帯再建術とその術後短期成績

  Matsushita Takehiko, Kuroda Ryosuke, Kubo Seiji, Matsumoto Tomoyuki, Kurosaka Masahiro

  Jun. 2012, JOSKAS, 37(4号) (4号), 401, Japanese

  [Refereed]

  Research society


• 人工膝関節単顆置換術における術中gap kinematics評価 CR型TKA、PS型TKAとの比較

  Matsumoto Tomoyuki, Kubo Seiji, Matsushita Takehiko, Kurosaka Masahiro, Kuroda Ryosuke

  Jun. 2012, JOSKAS, 37(4号) (4号), 347, Japanese

  [Refereed]

  Research society


• 偽関節治療の最先端 偽関節患者を対象とした自家末梢血CD34陽性細胞移植による骨・血管再生療法 臨床試験の報告

  新倉 隆彦, Kuroda Ryosuke, 松本 知之, 李 相亮, Mifune Yutaka, 古賀 敬章, 川上 洋平, 堂垣 佳宏, 奥町 悦子, Kurosaka Masahiro

  (一社)日本骨折治療学会, Jun. 2012, 骨折, 34(Suppl.) (Suppl.), S21 - S21, Japanese

  Research society


• The natural degeneration course in the T1rho values of normal knee cartilage

  Goto H, Iwama Y, Fujii M, Aoyama N, Kubo Seiji, Kuroda Ryosuke, Ohno Yoshiharu, Sugimura K

  The purpose of our study is to investigate whether there is an age-related change in T1 rho values and to evaluate the effects of weight bearing on age-related increase in T1 rho values of normal cartilage. Thirty-two asymptomatic patients were examined using a 3.0T MRI to determine knee cartilage T1 rho values. Femorotibial and patella cartilage was defined as weight-bearing cartilage (WB-C) and non-weight-bearing cartilage (NWB-C), respectively. The femoral cartilage was divided into weight-bearing (WB-P) and less-weight-bearing (LWB-P) portions. Pearson's correlation coefficient and single regression analysis were used to assess the relationship between cartilage T1 rho values and age. The slopes of the regression lines of cartilage T1 rho values and age were compared between WB-C and NWB-C and between WB-P and LWB-P. Cartilage T1 rho values correlated positively with aging for all cartilage regions and all age groups (p<0.001). In the medial femoral cartilage, the age-related increase in T1 rho values was significantly greater for WB-P than for NWB-P (p<0.05). For several cartilage regions, this increase was greater for WB-C than for LWB-C (p<0.05). The T1 rho value is very sensitive to age-related cartilage degeneration and weight bearing-related degeneration, and hence may be a very sensitive and useful measure for the early diagnosis of osteoarthritis.

  Jun. 2012, Kobe J Med Sci, 57(4) (4), E155 - 70, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The influence of patellar position on soft tissue balance in minimal incision total knee arthroplasty

  Shinya Oka, Hirotsugu Muratsu, Tomoyuki Matsumoto, Seiji Kubo, Akihiro Maruo, Hidetoshi Miya, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2012, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 20(6) (6), 1064 - 1068, English

  Scientific journal


• Pivot shift testの定量的評価と臨床的評価の関連性 International multicenter study

  Kuroda Ryosuke, Kurosaka Masahiro

  Jun. 2012, JOSKAS, 37(4号) (4号), 211, Japanese

  Research society


• MPFL再建術時の大腿骨側再建位置シミュレーション

  Kuroda Ryosuke, Kubo Seiji, Matsushita Takehiko, Matsumoto Tomoyuki, Kurosaka Masahiro

  Jun. 2012, JOSKAS, 37(4号) (4号), 226, Japanese

  Research society


• Intra-articular nodular fasciitis of the knee: a rare cause of recurrent hemarthrosis

  Tokio Matsuzaki, Toshihiro Akisue, Kenta Kishimoto, Shin-ichiro Kishimoto, Masaya Imabori, Hitomi Hara, Yoshiyuki Okada, Toshiaki Hitora, Ryosuke Kuroda, Masahiro Kurosaka, Tetsuji Yamamoto

  Jun. 2012, RHEUMATOLOGY INTERNATIONAL, 32(6) (6), 1691 - 1694, English

  Scientific journal


• CR-TKAにおける術中軟部組織バランスと術後アウトカムの関係

  Matsumoto Tomoyuki, Kubo Seiji, Matsushita Takehiko, Kurosaka Masahiro, Kuroda Ryosuke

  Jun. 2012, JOSKAS, 37(4号) (4号), 48, Japanese

  Research society


• Autophagy modulates osteoarthritis-related gene expression in human chondrocytes

  Hiroshi Sasaki, Koji Takayama, Takehiko Matsushita, Kazunari Ishida, Seiji Kubo, Tomoyuki Matsumoto, Norifumi Fujita, Shinya Oka, Masahiro Kurosaka, Ryosuke Kuroda

  Jun. 2012, ARTHRITIS AND RHEUMATISM, 64(6) (6), 1920 - 1928, English

  Scientific journal


• An analysis of surface profile for cylindrical osteochondral grafts of the knee quantitative evaluation using a three-dimensional laser scanner

  Kuroda Ryosuke, Matsumoto Tomoyuki, Matsushita Takehiko, Kubo Seiji, Kurosaka Masahiro

  Jun. 2012, Knee Surg Sports Traumatol Arthrosc, 27(9) (9), 1723 - 30, English

  [Refereed]

  Scientific journal


• ACL再再建術 術式の工夫と成績 ACL再再建術 術式の工夫と成績

  Kurosaka Masahiro, Kuroda Ryosuke, Kubo Seiji, Matsushita Takehiko, Matsumoto Tomoyuki

  Jun. 2012, JOSKAS, 37(4号) (4号), 19, Japanese

  [Invited]

  Research society


• ACL再建術後のスポーツ復帰 現状と課題 ACL再建術後のスポーツ復帰 動作解析からの評価

  Kuroda Ryosuke, Matsushita Takehiko, Matsumoto Tomoyuki, Kubo Seiji, Kurosaka Masahiro

  Jun. 2012, JOSKAS, 37(4号) (4号), 200, Japanese

  [Refereed][Invited]

  Research society


• ACL augmentationと解剖学的二重束ACL再建術の術前後不安定性の検討

  Kuroda Ryosuke, Matsushita Takehiko, Kubo Seiji, Matsumoto Tomoyuki, Nagamune Kouki, Kurosaka Masahiro

  Jun. 2012, JOSKAS, 37(4号) (4号), 75, Japanese

  [Refereed]

  Research society


• Acceleration of Tendon-Bone Healing of Anterior Cruciate Ligament Graft Using Autologous Ruptured Tissue

  Tomoyuki Matsumoto, Seiji Kubo, Ken Sasaki, Yohei Kawakami, Shinya Oka, Hiroshi Sasaki, Koji Takayama, Katsumasa Tei, Takehiko Matsushita, Yutaka Mifune, Masahiro Kurosaka, Ryosuke Kuroda

  Jun. 2012, AMERICAN JOURNAL OF SPORTS MEDICINE, 40(6) (6), 1296 - 1302, English

  [Refereed]

  Scientific journal


• Therapeutic effect of local administration of low-dose simvastatin-conjugated gelatin hydrogel for fracture healing

  Tomoaki Fukui, Masaaki Ii, Taro Shoji, Tomoyuki Matsumoto, Yutaka Mifune, Yohei Kawakami, Hiroshi Akimaru, Atsuhiko Kawamoto, Tomoya Kuroda, Takashi Saito, Yasuhiko Tabata, Ryosuke Kuroda, Masahiro Kurosaka, Takayuki Asahara

  May 2012, JOURNAL OF BONE AND MINERAL RESEARCH, 27(5) (5), 1118 - 1131, English

  Scientific journal


• Soft tissue balance using the tibia first gap technique with navigation system in cruciate-retaining total knee arthroplasty

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Takehiko Matsushita, Kazunari Ishida, Hirosi Sasaki, Shinya Oka, Masahiro Kurosaka, Ryosuke Kuroda

  May 2012, INTERNATIONAL ORTHOPAEDICS, 36(5) (5), 975 - 980, English

  Scientific journal


• Autogenous osteochondral graft transplantation for steroid-induced osteonecrosis of the femoral condyle: A report of three young patients

  Norifumi Fujita, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Kazunari Ishida, Yuichi Hoshino, Koji Nishimoto, Masahiro Kurosaka, Ryosuke Kuroda

  Apr. 2012, Sports Medicine, Arthroscopy, Rehabilitation, Therapy and Technology, 4(1) (1), 13, English

  [Refereed]

  Scientific journal


• Isolation and characterization of human anterior cruciate ligament-derived vascular stem cells

  Tomoyuki Matsumoto, Sheila M. Ingham, Yutaka Mifune, Aki Osawa, Alison Logar, Arvydas Usas, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H. Fu, Johnny Huard

  Apr. 2012, Stem Cells and Development, 21(6) (6), 859 - 872, English

  [Refereed]

  Scientific journal


• Standardized pivot shift test improves measurement accuracy.

  Yuichi Hoshino, Paulo Araujo, Mattias Ahlden, Charity G Moore, Ryosuke Kuroda, Stefano Zaffagnini, Jon Karlsson, Freddie H Fu, Volker Musahl

  PURPOSE: The variability of the pivot shift test techniques greatly interferes with achieving a quantitative and generally comparable measurement. The purpose of this study was to compare the variation of the quantitative pivot shift measurements with different surgeons' preferred techniques to a standardized technique. The hypothesis was that standardizing the pivot shift test would improve consistency in the quantitative evaluation when compared with surgeon-specific techniques. METHODS: A whole lower body cadaveric specimen was prepared to have a low-grade pivot shift on one side and high-grade pivot shift on the other side. Twelve expert surgeons performed the pivot shift test using (1) their preferred technique and (2) a standardized technique. Electromagnetic tracking was utilized to measure anterior tibial translation and acceleration of the reduction during the pivot shift test. The variation of the measurement was compared between the surgeons' preferred technique and the standardized technique. RESULTS: The anterior tibial translation during pivot shift test was similar between using surgeons' preferred technique (left 24.0 ± 4.3 mm; right 15.5 ± 3.8 mm) and using standardized technique (left 25.1 ± 3.2 mm; right 15.6 ± 4.0 mm; n.s.). However, the variation in acceleration was significantly smaller with the standardized technique (left 3.0 ± 1.3 mm/s(2); right 2.5 ± 0.7 mm/s(2)) compared with the surgeons' preferred technique (left 4.3 ± 3.3 mm/s(2); right 3.4 ± 2.3 mm/s(2); both P < 0.01). CONCLUSION: Standardizing the pivot shift test maneuver provides a more consistent quantitative evaluation and may be helpful in designing future multicenter clinical outcome trials. LEVEL OF EVIDENCE: Diagnostic study, Level I.

  Apr. 2012, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 20(4) (4), 732 - 6, English, International magazine

  [Refereed]


• 未来の人工材料 ゼラチンハイドロゲルを用いた運動器再生の基礎研究

  Kuroda Ryosuke, Matsumoto Tomoyuki, Matsushita Takehiko, Kurosaka Masahiro

  Apr. 2012, 中部日本整形外科災害外科学会雑誌, 55(春季学会) (春季学会), 162, Japanese

  Research society


• 前十字靱帯不全膝における覚醒下と全身麻酔下での膝不安定性の相違 Lachman testとPivot shift test

  Kuroda Ryosuke, Matsushita Takehiko, Kubo Seiji, Nagamune Kouki, Kurosaka Masahiro

  Apr. 2012, 中部日本整形外科災害外科学会雑誌, 55(春季学会) (春季学会), 253, Japanese

  Research society


• 【難治性骨折に対する治療】 骨癒合促進のチャレンジ 難治性骨折(偽関節)患者を対象とした自家末梢血CD34陽性細胞移植による骨・血管再生療法

  Kuroda Ryosuke, Niikura Takahiro, Matsumoto Tomoyuki, Lee Sangyang, Kurosaka Masahiro

  (株)南江堂, Apr. 2012, 別冊整形外科, (61号) (61号), 224 - 228, Japanese

  [Refereed]

  Scientific journal


• Quantitative measurement of the pivot shift, reliability, and clinical applications

  Ryosuke Kuroda, Yuichi Hoshino, Daisuke Araki, Yuichiro Nishizawa, Kouki Nagamune, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Masahiro Kurosaka

  Apr. 2012, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 20(4) (4), 686 - 691, English

  [Refereed]

  Scientific journal


• An analysis of bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein 2 from a biodegradable sponge composed of gelatin and ss-tricalcium phosphate

  N. Fujita, T. Matsushita, K. Ishida, K. Sasaki, S. Kubo, T. Matsumoto, M. Kurosaka, Y. Tabata, R. Kuroda

  Apr. 2012, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6(4) (4), 291 - 298, English

  [Refereed]

  Scientific journal


• 人工膝関節全置換術における術中軟部組織バランスの中期臨床成績に及ぼす影響 術中計測値と術後5年での膝安定性の相関

  Matsumoto Tomoyuki, Kubo Seiji, Matsushita Takehiko, Kurosaka Masahiro, Kuroda Ryosuke

  Mar. 2012, 日本整形外科学会雑誌, 86(3号) (3号), S708, Japanese

  Research society


• 診断に難渋した膝関節滑膜性骨軟骨腫症の1例

  Kubo Seiji, Matsumoto Tomoyuki, Matsushita Takehiko, Kuroda Ryosuke, Kawamoto Teruya, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Mar. 2012, 中部日本整形外科災害外科学会雑誌, 55(2) (2), 436 - 437, Japanese

  [Refereed]

  Research society


• 骨盤・寛骨臼骨折での静脈血栓塞栓症の発生状況

  Niikura Takahiro, Lee Sangyang, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2012, 日本整形外科学会雑誌, 86(3号) (3号), S749, Japanese

  Research society


• 骨盤・下肢骨折症例における静脈血栓塞栓症の発生とトロンビン・アンチトロンビンIII複合体(TAT)の関係

  Lee Sangyang, Niikura Takahiro, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2012, 日本整形外科学会雑誌, 86(3号) (3号), S750, Japanese

  Research society


• 骨盤・下肢骨折における静脈血栓塞栓症スクリーニング法の改良

  Niikura Takahiro, Lee Sangyang, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2012, 日本整形外科学会雑誌, 86(3号) (3号), S750, Japanese

  Research society


• Influence of intra-operative joint gaps on post-operative flexion angle in posterior cruciate-retaining total knee arthroplasty

  Koji Takayama, Tomoyuki Matsumoto, Seiji Kubo, Hirotsugu Muratsu, Kazunari Ishida, Takehiko Matsushita, Masahiro Kurosaka, Ryosuke Kuroda

  Mar. 2012, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 20(3) (3), 532 - 537, English

  Scientific journal


• 脛骨後方傾斜が術中軟部組織バランスに及ぼす影響 CR型、PS型TKAでの比較

  Matsumoto Tomoyuki, Kubo Seiji, Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  Feb. 2012, 日本整形外科学会雑誌, 86(2号) (2号), S63, Japanese

  Research society


• 膝前十字靱帯不全膝(機能不全膝)の回旋不安定性の定量的評価方法の検討

  Kuroda Ryosuke, Nagamune Kouki, Matsumoto Tomoyuki, Matsushita Takehiko, Kubo Seiji, Kurosaka Masahiro

  (公社)日本整形外科学会, Feb. 2012, 日本整形外科学会雑誌, 86(2号) (2号), S56 - S56, Japanese

  Research society


• 膝前十字靱帯再建術の現状と展開 膝前十字靱帯再建術における不安定性の客観的評価

  Kuroda Ryosuke, Matsushita Takehiko, Matsumoto Tomoyuki, Kubo Seiji, Kurosaka Masahiro

  Feb. 2012, 日本整形外科学会雑誌, 86(2号) (2号), S219, Japanese

  [Refereed]

  Research society


• 前十字靱帯損傷に対するpivot shift testの検者間における同様性と相違

  Matsushita Takehiko, Kuroda Ryosuke, Kubo Seiji, Matsumoto Tomoyuki, Nagamune Kouki, Kurosaka Masahiro

  Feb. 2012, 日本整形外科学会雑誌, 86(2号) (2号), S56, Japanese

  Research society


• Combined osteochondral fracture of the posterolateral tibial plateau and Segond fracture with anterior cruciate ligament injury in a skeletally immature patient

  Katsumasa Tei, Seiji Kubo, Tomoyuki Matsumoto, Takehiko Matsushita, Akio Matsumoto, Masahiro Kurosaka, Ryosuke Kuroda

  Feb. 2012, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 20(2) (2), 252 - 255, English

  [Refereed]

  Scientific journal


• A Development of Force Distribution Measurement System in Total Knee Arthroplasty and Its Fundamental Results toward Clinical Examination

  Kamiya Takashi, Kawaguchi Shogo, Nagamune Kouki, Matsumoto Tomoyuki, matsushita takehiko, Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Recently, the number of total knee arthroplasty (TKA) has been more than 0.7 million with the aging of population in Japan. The number has been more than double in comparing with 10 years ago. Although it is well known that the soft tissue balance is important for the TKA, there is a problem that it depends much on past experiences of an examiner in clinical situation. Thus, a non-expert doctor makes deviation of the balance due to insufficient experiences. Then, we have been developing a system could provide an objective criterion to reduce the deviation. This study reports a force distribution by using a pressure sensor in case of 20 kgF loading which is a value in real situation. The results show loading movement with force distribution in extention and 90 degree flexion. As a result, the force distribution should be more similar to clinical situation. As a future work, it is to improve the measurement precision, and to use in clinical examination.

  Japan Society for Fuzzy Theory and Intelligent Informatics, 2012, Proceedings of the Fuzzy System Symposium, 28, 342 - 345, Japanese


• Angle Estimation of Instrument for Mosaicplasty by using Knowledge of Force Distribution

  Nishino Satoshi, Toyoshima Takayasu, Nagamune Kouki, Hoshino Yuichi, Matsumoto Tomoyuki, Matsushita Takehiko, Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Mosaicplasty is one of the surgeries for knee cartilage damage. It transplants the bone autograft with the cartilage to the injured area. In this surgery, it is important to harvest the cartilage graft vertically and transplant it vertically by using a harvester for preventing area around transplant from discontinuous of the cartilage surface. This study set the goal to develop a system to estimate the pose of harvester against the articular surface in considering with a force distribution measured by a force sensor. The proposed method measures a force distribution on the cartilage surface by using eight force sensors which are attached to the front edge of the harvestor of the surfical instrument. It estimates the angle between the articular surface and harvester based on the force distribution. The experiment used a portable force tester for loading, and estimated the angle of the harvester. The result shows the maximum of the angle estimation error was 8 degrees. The experiment of angle estimation performed multiple times, it was confirmed reproducibility. As a future work, angle of estimation is displayed in real time.

  Japan Society for Fuzzy Theory and Intelligent Informatics, 2012, Proceedings of the Fuzzy System Symposium, 28, 362 - 367, Japanese


• A Calibration Method of Pressure Sensor by Using Fuzzy Control in Manual Test

  Kawaguchi Shogo, Nagamune Kouki, Araki Daisuke, Hoshino Yuichi, Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Lachman test is one of the manual tests for examining the anterior cruciate ligament (ACL). An examiner discriminates a degree of the ACL injury by feeling of a stress on the finger. Because the feeling is subjective consideration, the dicrimination depends much on past experiences. However, a non-expert examiner makes a deviation about the discrimination due to insufficient experiences. In addition, the feeling is not so constant, it results in another deviation even though an expert examiner performs. Hence, this study has developed a quantitative measurement system for Lachman test to reduce the deviation, and to provide an objective criterion. This measurement system consists of finger braces and force sensors on each fingers. Although a pressure sensor needs to calibrate in general, the calibration value of this system depends on difference of finger diameters. Keeping system accuracy requires a stable calibration method. This study proposes a calibration method adopted to the finger diameters by using Fuzzy Control. In the experiment, the proposed system examined both hands of young male, resulted high accuracy in low loading. A futur work is to evaluate reliability of this system in clinical situation.

  Japan Society for Fuzzy Theory and Intelligent Informatics, 2012, Proceedings of the Fuzzy System Symposium, 28, 324 - 329, Japanese


• A Proposal for Automated Analytical Method of MDCT Images for Risk Measurement of Recurrent Patellar Dislocation

  Maki Akira, Nagamune Kouki, Oka Shinya, Hoshino Yuichi, Matsushita Takehiko, Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Currently, doctors determine a treatment way of recurrent patellar dislocation with total consideration for the knee condition by using image discrimination and/or palpation. However, the determination depends much on the doctors. It results in variations of the judgment among them. Therefore, this study aims to propose an automated evaluation method that can provide a criterion of the subluxation knee for determination of a treatment to support doctors without subjective experiences. The proposed method analyzes an abnormal degree of patellofemoral surface by calculating a femoral pose from the medial and lateral epicondyles and detecting a patellar displacement and a profile of the groove. Then, it can provide a value represents a risk of the subluxation by considering them totally.

  Japan Society for Fuzzy Theory and Intelligent Informatics, 2012, Proceedings of the Fuzzy System Symposium, 28, 320 - 323, Japanese


• Challenge of Normality Evaluation by using Micro-Size Tension Measurement Device in Anterior Cruciate Ligament Reconstruction

  Kawaguchi Shogo, Nagamune Kouki, Oka Shinya, Nishizawa Yuichiro, Hoshino Yuichi, Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Anterior Cruciate Ligament (ACL) is one of the important ligaments in the knee. The ligament connects the femur and tibia, and has a role to prevent an excessive forward movement of the tibia. In the clinical sports medicine, ACL reconstruction is often preformed about the injured knee. The ACL reconstruction aims to recover the function of the knee. Although some study have reports tension pattern of the reconstructed knee during knee bending, no reports have reported an evaluation method of the normal tension pattern. This study tries to define the normality of the normal knee in considering the tension pattern. The experiment used an imitation bone with an imitation ligament for measuring the tension pattern by using our developed micro-measurement system, and evaluated the normality of the tension pattern. Future works are to apply this evaluation to cadaver knees.

  Japan Society for Fuzzy Theory and Intelligent Informatics, 2012, Proceedings of the Fuzzy System Symposium, 28, 314 - 319, Japanese


• 3次元電磁センサーを用いたサッカーのインサイドキックにおける動作解析

  佐々木 謙, 山口 基, 黒田 良祐, 荒木 大輔, 西澤 勇一郎, 長宗 高樹

  スポーツ傷害フォーラム, Jan. 2012, スポーツ傷害, 17, 20 - 20, Japanese


• Clinical application of drug derivery system for orthopaedic surgery

  Ryosuke Kuroda, Tomoaki Fukui, Kazunari Ishida, Ken Sasaki, Yasuhiko Tabata

  2012, Drug Delivery System, 27(4) (4), 283 - 288, English

  [Refereed]

  Scientific journal


• Severe laceration of flexor tendons after locking palmar plate fixation of distal radius fracture: A case report

  Issei Nagura, Takeshi Kokubu, Yutaka Mifune, Kotaro Nishida, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka

  2012, Kobe Journal of Medical Sciences, 58(3) (3), E82 - E85, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Nontraumatic true aneurysm of the superficial palmar arch: A case report

  Issei Nagura, Takeshi Kokubu, Hiroyuki Fujioka, Yutaka Mifune, Kotaro Nishida, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka

  2012, Kobe Journal of Medical Sciences, 58(1) (1), E29 - E32, English

  [Refereed]

  Scientific journal


• Challenge of Normality Evaluation by using Micro-Size Tension Measurement Device in Anterior Cruciate Ligament Reconstruction

  Shogo Kawaguchi, Kouki Nagamune, Yuichiro Nishizawa, Yuichi Hoshino, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2012, PROCEEDINGS 2012 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN, AND CYBERNETICS (SMC), 2605 - 2609, English

  [Refereed]

  International conference proceedings


• A Registration Method of 3D Profile and Motion Data of the Knee Kinematics

  Kouki Nagamune, Shinya Oka, Daisuke Araki, Koji Nishimoto, Seiji Kubo, Ryosuke Kuroda, Masahiro Kurosaka

  2012, 2012 WORLD AUTOMATION CONGRESS (WAC), English

  [Refereed]

  International conference proceedings


• Calculation of Graft Bending Angle in Anterior Cruciate Ligament Reconstruction

  Kouki Nagamune, Yuichiro Nishizawa, Koji Nishimto, Yuichi Hoshino, Seiji Kubo, Ryosuke Kuroda, Masahiro Kurosaka

  2012, PROCEEDINGS 2012 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN, AND CYBERNETICS (SMC), 237 - 241, English

  [Refereed]

  International conference proceedings


• A Development of Force Distribution Measurement System in Total Knee Arthroplasty and With High Resolution

  Takashi Kamiya, Shogo Kawaguchi, Mohd Hanafi Mat Som, Kouki Nagamune, Tomoyuki Matsumoto, Takehiko Matsushita, Seiji Kubo, Ryosuke Kuroda, Masahiro Kurosaka

  2012, 6TH INTERNATIONAL CONFERENCE ON SOFT COMPUTING AND INTELLIGENT SYSTEMS, AND THE 13TH INTERNATIONAL SYMPOSIUM ON ADVANCED INTELLIGENT SYSTEMS, 785 - 788, English

  [Refereed]

  International conference proceedings


• A Development of Navigation System with Image Segmentation in Mosaicplasty of the Knee

  Takayasu Toyoshima, Kouki Nagamune, Daisuke Araki, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2012, 2012 IEEE INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS (FUZZ-IEEE), English

  [Refereed]

  International conference proceedings


• An Automated Calibration by Using Fuzzy Control for a Measurement System of Lachman Test

  Shogo Kawaguchi, Kouki Nagamune, Daisuke Araki, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2012, 2012 IEEE INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS (FUZZ-IEEE), English

  [Refereed]

  International conference proceedings


• A Development of Surgery Instrument Pose Support System for Mosaicplasty by Using Force Distribution

  Satoshi Nishino, Takayasu Toyoshima, Kouki Nagamune, Yuichi Hoshino, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2012, PROCEEDINGS 2012 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN, AND CYBERNETICS (SMC), 3269 - 3274, English

  [Refereed]

  International conference proceedings


• Lateral supra-acetabular external fixation for unstable pelvic ring fracture: A biomechanical assessments

  M. M S Hanafi, Shogo Kawaguchi, Kouki Nagamune, Keisuke Oe, Sang Yang Lee, Takahiro Niikura, Ryosuke Kuroda, Masahiro Kurosaka

  2012, IEEE International Conference on Fuzzy Systems, 1 - 6, English

  [Refereed]

  International conference proceedings


• Transcutaneous application of carbon dioxide (CO 2) enhances chemosensitivity by reducing hypoxic conditions in human malignant fibrous histiocytoma--174-181

  Yasuo Onishi, Teruya Kawamoto, Takeshi Ueha, Hitomi Hara, Naomasa Fukase, Mitsunori Toda, Risa Harada, Yoshitada Sakai, Masahiko Miwa, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka, Toshihiro Akisue

  2012, Journal of Cancer Science and Therapy, 4(7) (7), 3

  [Refereed]

  Scientific journal


• Therapeutic potential of anterior cruciate ligament-derived stem cells for anterior cruciate ligament reconstruction

  Yutaka Mifune, Tomoyuki Matsumoto, Shusuke Ota, Makoto Nishimori, Arvydas Usas, Sebastian Kopf, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H. Fu, Johnny Huard

  2012, Cell Transplantation, 21(8) (8), 1651 - 1665, English

  [Refereed]

  Scientific journal


• Local transplantation of granulocyte colony-stimulating factor-mobilized human peripheral blood mononuclear cells for unhealing bone fractures

  Tomoaki Fukui, Tomoyuki Matsumoto, Yutaka Mifune, Taro Shoji, Tomoya Kuroda, Yohei Kawakami, Atsuhiko Kawamoto, Masaaki Ii, Shin Kawamata, Masahiro Kurosaka, Takayuki Asahara, Ryosuke Kuroda

  Cognizant Communication Corporation, 2012, Cell Transplantation, 21(4) (4), 707 - 721, English

  [Refereed]

  Scientific journal


• Local transplantation of ex vivo expanded bone marrow-derived CD34-positive cells accelerates fracture healing.

  Kawakami Y, Ii M, Alev C, Kawamoto A, Matsumoto T, Kuroda R, Shoji T, Fukui T, Masuda H, Akimaru H, Mifune Y, Kuroda T, Horii M, Yokoyama A, Kurosaka M, Asahara T

  Transplantation of bone marrow (BM) CD34(+) cells, an endothelial/hematopoietic progenitor-enriched cell population, has shown therapeutic efficiency in the treatment of ischemic diseases enhancing neovascularization. However, the number of CD34(+) cells obtained from bone marrow is not sufficient for routine clinical application. To overcome this issue, we developed a more efficient and clinically applicable CD34(+) cell expansion method. Seven-day ex vivo expansion culture of BM CD34(+) cells with a cocktail of five growth factors containing VEGF, SCF, IL-6, Flt-3 ligand, and TPO resulted in reproducible more than 20-fold increase in cell number. The favorable effect of the local transplantation of culture expanded (cEx)-BM CD34(+) cells on rat unhealing fractures was equivalent or higher than that of nonexpanded (fresh) BM CD34(+) cells exhibiting sufficient therapeutic outcome with frequent vasculogenic/osteogenic differentiation of transplanted cEx-BM CD34(+) cells and fresh BM CD34(+) cells as well as intrinsic enhancement of angiogenesis/osteogenesis at the treated fracture sites. Specifically, cEx-BM CD34(+) cell treatment demonstrated the best blood flow recovery at fracture sites compared with the nonexpanded BM CD34(+) cells. In vitro, cEx-BM CD34(+) cells showed higher colony/tube-forming capacity than nonexpanded BM CD34(+) cells. Both cells demonstrated differentiation potential into osteoblasts. Since fresh BM CD34(+) cells can be easily collected from fracture sites at the time of primary operation and stored for future use, autologous cEx-BM CD34(+) cell transplantation would be not only a simple but also a promising therapeutic strategy for unhealing fractures in the field of orthopedic trauma surgery.

  2012, Cell transplantation, 21(12) (12), 2689 - 2709, English, International magazine

  [Refereed]

  Scientific journal


• Radiation-associated fracture nonunion of the clavicle treated with locking plate fixation and autologous bone grafting

  Takahiro Niikura, Sang Yang Lee, Yoshitada Sakai, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Hindawi Limited, 2012, Case Reports in Medicine, 2012, 407349, English

  [Refereed]

  Scientific journal


• Simulation of the optimal insertion for MPFL reconstruction

  Masahiro NORO, Mitsumasa MATSUDA, Ryosuke KURODA, Seiji KUBO, Takehiko MATSUSITA, Shinya OKA, Tomoyuki MATSUMOTO, Yuichiro NISHIZAWA, Masahiro KUROSAKA

  2012, Japanese Journal of Clinical Biomechanics, Vol.33・pp179-184, Japanese

  [Refereed]

  Scientific journal


• Energy consumption during prosthetic walking and physical fitness in older hip disarticulation amputees

  Takaaki Chin, Ryosuke Kuroda, Toshihiro Akisue, Tetsuhiro Iguchi, Masahiro Kurosaka

  2012, JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT, 49(8) (8), 1255 - 1260, English

  [Refereed]

  Scientific journal


• 巨大遊離骨軟骨片を伴った離断性骨軟骨炎に対して遊離骨軟骨片骨固定術と骨軟骨柱移植術を併用した2例

  Kuroda Ryosuke, Matsushita Takehiko, Kubo Seiji, Matsumoto Tomoyuki, Kurosaka Masahiro

  Jan. 2012, スポーツ傷害, 17, 13, Japanese

  [Refereed]

  Research society


• Similarities and Differences of Diagnostic Manual Tests for Anterior Cruciate Ligament Insufficiency A Global Survey and Kinematics Assessment

  Ryosuke Kuroda, Yuichi Hoshino, Seiji Kubo, Daisuke Araki, Shinya Oka, Kouki Nagamune, Masahiro Kurosaka

  Jan. 2012, AMERICAN JOURNAL OF SPORTS MEDICINE, 40(1) (1), 91 - 99, English

  [Refereed]

  Scientific journal


• The Influence of Preoperative Deformity on Intraoperative Soft Tissue Balance in Posterior-Stabilized Total Knee Arthroplasty

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Takehiko Matsushita, Masahiro Kurosaka, Ryosuke Kuroda

  Dec. 2011, JOURNAL OF ARTHROPLASTY, 26(8) (8), 1291 - 1298, English

  [Refereed]

  Scientific journal


• Differing Prosthetic Alignment and Femoral Component Sizing Between 2 Computer-assisted CT-free Navigation Systems in TKA

  Tomoyuki Matsumoto, Seiji Kubo, Hirotsugu Muratsu, Nobuhiro Tsumura, Kazunari Ishida, Takehiko Matsushita, Koji Takayama, Hiroshi Sasaki, Shinya Oka, Masahiro Kurosaka, Ryosuke Kuroda

  Dec. 2011, ORTHOPEDICS, 34(12) (12), 952 - 952, English

  [Refereed]

  Scientific journal


• Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty

  Kazunari Ishida, Nobuhiro Tsumura, Atsushi Kitagawa, Sayaka Hamamura, Koji Fukuda, Yoshihiro Dogaki, Seiji Kubo, Tomoyuki Matsumoto, Takehiko Matsushita, Takaaki Chin, Tetsuhiro Iguchi, Masahiro Kurosaka, Ryosuke Kuroda

  Nov. 2011, INTERNATIONAL ORTHOPAEDICS, 35(11) (11), 1639 - 1645, English

  Scientific journal


• 変形性膝関節症の介入研究の短期成績 踵の衝撃吸収性に優れた靴の変形性膝関節症に対する効果

  Kuroda Ryosuke, Kubo Seiji, Matsumoto Tomoyuki, Kurosaka Masahiro

  日本整形外科学会, Oct. 2011, 日本整形外科学会雑誌, 85巻, 10号, pp. 755-760(10) (10), 755 - 760, Japanese

  [Refereed]

  Scientific journal


• 膝後外側支持機構損傷を伴った前十字靱帯損傷に対して前十字靱帯再建術と高位脛骨骨切り術を施行しスポーツ復帰した1例

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  Oct. 2011, 日本臨床スポーツ医学会誌, 19巻, 4号, pp. S179-S179, Japanese

  International conference proceedings


• 前十字靱帯損傷後の変形性膝関節症に対して高位骨切り術を施行した2例

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  Oct. 2011, 日本臨床スポーツ医学会誌, 19巻, 4号, pp. S196-S196, Japanese

  International conference proceedings


• 私が薦めるACL損傷からの競技復帰プラン サッカー選手のACL損傷に対する治療 損傷からの競技復帰プラン

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  Oct. 2011, 日本臨床スポーツ医学会誌, 19巻, 4号, pp. S85-S85, Japanese

  International conference proceedings


• 【人工膝関節のデザインとバイオメカニクス】 人工膝関節の三次元解析 術中軟部組織バランスがTKA術後キネマティクスに及ぼす影響

  Kubo Seiji, Matsumoto Tomoyuki, Kuroda Ryosuke

  Oct. 2011, 関節外科, 30巻, 10月増刊, pp. 112-115, Japanese

  [Refereed]

  Scientific journal


• 膝前十字靱帯由来CD34陽性細胞シート被覆移植腱を用いた膝前十字靱帯再建術

  Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2011, 日本整形外科学会雑誌, 85巻, 8号, pp. S1249-S1249, Japanese

  International conference proceedings


• 膝前十字靱帯再建術における損傷部靱帯組織併用療法の可能性

  Kubo Seiji, Kurosaka Masahiro, Kuroda Ryosuke

  (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85巻, 8号, pp. S1248-S1248(8) (8), S1248 - S1248, Japanese

  International conference proceedings


• 体外増幅ヒト骨髄由来CD34陽性細胞を用いた難治性骨折に対する新規治療法

  Kuroda Ryosuke, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85巻, 8号, pp. S1202-S1202(8) (8), S1202 - S1202, Japanese

  International conference proceedings


• 細胞内アダプター蛋白質Lnkの局所制御による、早期の血管新生を通じた骨折治癒促進の可能性

  Kuroda Ryosuke, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85巻, 8号, pp. S1214-S1214(8) (8), S1214 - S1214, Japanese

  International conference proceedings


• 運動器の再生 末梢血細胞を用いた骨・血管再生療法による偽関節治療

  Niikura Takahiro, Lee Sangyang, Kurosaka Masahiro, Kuroda Ryosuke

  (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85巻, 8号, pp. S1182-S1182(8) (8), S1182 - S1182, Japanese

  [Refereed]

  International conference proceedings


• ヒト軟骨組織と軟骨細胞におけるオートファジーの解析

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  Aug. 2011, 日本整形外科学会雑誌, 85巻, 8号, pp. S1156-S1156, Japanese

  International conference proceedings


• The double ACL sign: an unusual bucket-handle tear of medial meniscus

  Koji Takayama, Takehiko Matsushita, Tomoyuki Matsumoto, Seiji Kubo, Masahiro Kurosaka, Ryosuke Kuroda

  Aug. 2011, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 19(8) (8), 1343 - 1346, English

  [Refereed]

  Scientific journal


• Soft Tissue Tension in Cruciate-Retaining and Posterior-Stabilized Total Knee Arthroplasty

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Takehiko Matsushita, Masahiro Kurosaka, Ryosuke Kuroda

  Aug. 2011, JOURNAL OF ARTHROPLASTY, 26(5) (5), 788 - 795, English

  [Refereed]

  Scientific journal


• PRPによる筋肉由来幹細胞を用いた軟骨修復治療の促進

  Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2011, 日本整形外科学会雑誌, 85巻, 8号, pp. S1267-S1267, Japanese

  International conference proceedings


• Intimate relationship between instability and degenerative signs at L4/5 segment examined by flexion-extension radiography

  Tetsuhiro Iguchi, Takuma Ozaki, Takaaki Chin, Nobuhiro Tsumura, Aritetsu Kanemura, Koichi Kasahara, Ryosuke Kuroda, Minoru Doita, Kotaro Nishida

  Aug. 2011, EUROPEAN SPINE JOURNAL, 20(8) (8), 1349 - 1354, English

  [Refereed]

  Scientific journal


• ACL再建術の術後評価 3次元電磁気センサーによる評価

  Kuroda Ryosuke, Kubo Seiji

  (一社)日本整形外科スポーツ医学会, Aug. 2011, 日本整形外科スポーツ医学会雑誌, 31巻, 4号, pp. 406-406(4) (4), 406 - 406, Japanese

  International conference proceedings


• 偽関節患者を対象とした自家末梢血CD34陽性細胞移植による骨・血管再生療法(第一報)

  Niikura Takahiro, Kuroda Ryosuke, Lee Sangyang, Kurosaka Masahiro

  (一社)日本骨折治療学会, Jul. 2011, 骨折, 33巻, Suppl., pp. S310-S310(Suppl.) (Suppl.), S310 - S310, Japanese

  [Refereed]

  International conference proceedings


• Mid-term outcomes of computer-assisted total knee arthroplasty

  Kazunari Ishida, Tomoyuki Matsumoto, Nobuhiro Tsumura, Seiji Kubo, Atsushi Kitagawa, Takaaki Chin, Tetsuhiro Iguchi, Masahiro Kurosaka, Ryosuke Kuroda

  Jul. 2011, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 19(7) (7), 1107 - 1112, English

  [Refereed]

  Scientific journal


• DcR3 induces cell proliferation through MAPK signaling in chondrocytes of osteoarthritis

  S. Hayashi, T. Nishiyama, Y. Miura, T. Fujishiro, N. Kanzaki, S. Hashimoto, T. Matsumoto, M. Kurosaka, R. Kuroda

  Jul. 2011, OSTEOARTHRITIS AND CARTILAGE, 19(7) (7), 903 - 910, English

  [Refereed]

  Scientific journal


• Comparison of the Clinical Outcome of Double-Bundle, Anteromedial Single-Bundle, and Posterolateral Single-Bundle Anterior Cruciate Ligament Reconstruction Using Hamstring Tendon Graft With Minimum 2-Year Follow-up

  Norifumi Fujita, Ryosuke Kuroda, Tomoyuki Matsumoto, Motoi Yamaguchi, Masayoshi Yagi, Akio Matsumoto, Seiji Kubo, Takehiko Matsushita, Yuichi Hoshino, Koji Nishimoto, Daisuke Araki, Masahiro Kurosaka

  Jul. 2011, ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 27(7) (7), English

  [Refereed]

  Scientific journal


• 2重束ACL再建における脛骨側骨孔位置の3D-CTによる評価

  佐々木 謙, 山口 基, 中山 寛, 吉矢 晋一, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2011, JOSKAS, 36(4) (4), 139 - 139, Japanese


• 2重束ACL再建術の3D-CTによる脛骨骨孔位置と術後成績の関係

  山口 基, 佐々木 謙, 中山 寛, 吉矢 晋一, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2011, JOSKAS, 36(4) (4), 274 - 274, Japanese


• 半腱用筋腱を用いたMPFL再建術の術後成績

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2011, JOSKAS, 36巻, 4号, pp. 284-284(4) (4), 284 - 284, Japanese

  International conference proceedings


• 人工膝関節全置換術におけるナビゲーションシステム2機種による大腿骨コンポーネント設置角度およびそのsizingへの影響

  Kubo Seiji, Kurosaka Masahiro, Kuroda Ryosuke

  Jun. 2011, JOSKAS, 36巻, 4号, pp. 43-43, Japanese

  International conference proceedings


• 悪性骨軟部腫瘍との鑑別が必要であった関節リウマチの3例

  Kuroda Ryosuke, Kurosaka Masahiro

  (一社)日本リウマチ学会, Jun. 2011, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集55回・20回, 巻, , pp. 535-535, 535 - 535, Japanese

  International conference proceedings


• The Use of an Electromagnetic Measurement System for Anterior Tibial Displacement During the Lachman Test

  Daisuke Araki, Ryosuke Kuroda, Seiji Kubo, Kouki Nagamune, Yuichi Hoshino, Koji Nishimoto, Koji Takayama, Takehiko Matsushita, Katsumasa Tei, Motoi Yamaguchi, Masahiro Kurosaka

  Jun. 2011, ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 27(6) (6), 792 - 802, English

  [Refereed]

  Scientific journal


• Soft tissue balance measurement in minimal incision surgery compared to conventional total knee arthroplasty

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Kiyonori Mizuno, Keisuke Kinoshita, Kazunari Ishida, Takehiko Matsushita, Ken Sasaki, Katsumasa Tei, Koji Takayama, Hiroshi Sasaki, Shinya Oka, Masahiro Kurosaka, Ryosuke Kuroda

  Jun. 2011, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 19(6) (6), 880 - 886, English

  [Refereed]

  Scientific journal


• Revision ACL再建術の術後成績

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2011, JOSKAS, 36巻, 4号, pp. 137-137(4) (4), 137 - 137, Japanese

  International conference proceedings


• Puddu plateを用いたopen-wedge高位脛骨骨切り術の治療成績

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2011, JOSKAS, 36巻, 4号, pp. 59-59(4) (4), 59 - 59, Japanese

  International conference proceedings


• ACL Reconstruction:Where are we now and where should we go? 前十字靱帯(ACL)再建術の現況と今後の課題

  Kurosaka Masahiro, Kuroda Ryosuke, Kubo Seiji

  Jun. 2011, JOSKAS, 36巻, 4号, pp. 4-4, Japanese

  International conference proceedings


• Therapeutic strategy of third-generation autologous chondrocyte implantation for osteoarthritis

  Tomoya Kuroda, Tomoyuki Matsumoto, Yutaka Mifune, Tomoaki Fukui, Seiji Kubo, Takehiko Matsushita, Takayuki Asahara, Masahiro Kurosaka, Ryosuke Kuroda

  May 2011, UPSALA JOURNAL OF MEDICAL SCIENCES, 116(2) (2), 107 - 114, English

  [Refereed]

  Scientific journal


• T2マッピングによる関節軟骨の変性の評価 病理組織所見との対比

  Kubo Seiji, Fujii Masahiko, Kuroda Ryosuke, Kurosaka Masahiro

  May 2011, 関節外科, 30巻, 5号, pp. 650-656, Japanese

  [Refereed]

  Scientific journal


• 片脚立位保持時間と質問紙評価から前十字靱帯再建術後の片脚運動野力の推定が可能か スポーツ復帰活動度による違い

  伊藤 浩充, 登 有紀, 瀧口 耕平, 木田 晃弘, 柴田 洋平, 小野 くみ子, 黒田 良祐, 黒坂 昌弘

  (公社)日本理学療法士協会, Apr. 2011, 理学療法学, 38(Suppl.2) (Suppl.2), PI2 - 277, Japanese


• Total Knee Arthroplasty Combined With Medial Patellofemoral Ligament Reconstruction for Osteoarthritic Knee With Preoperative Valgus Deformity and Chronic Patellar Dislocation

  Takehiko Matsushita, Ryosuke Kuroda, Seiji Kubo, Kiyonori Mizuno, Tomoyuki Matsumoto, Masahiro Kurosaka

  Apr. 2011, Journal of Arthroplasty, 26(3) (3), 505 - e20, English

  [Refereed]

  Scientific journal


• Potential Involvement of SIRT1 in the Pathogenesis of Osteoarthritis Through the Modulation of Chondrocyte Gene Expressions

  Norifumi Fujita, Takehiko Matsushita, Kazunari Ishida, Seiji Kubo, Tomoyuki Matsumoto, Koji Takayama, Masahiro Kurosaka, Ryosuke Kuroda

  Apr. 2011, JOURNAL OF ORTHOPAEDIC RESEARCH, 29(4) (4), 511 - 515, English

  [Refereed]

  Scientific journal


• 多発性巨大骨嚢腫を伴った両側膝関節症に対してTKAを施行した一例

  Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2011, 中部日本整形外科災害外科学会雑誌, 54巻, 春季学会, pp. 202-202, Japanese

  International conference proceedings


• 前十字靱帯不全膝における膝最大伸展位での脛骨前方偏位の検討

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2011, 日本整形外科学会雑誌, 85巻, 3号, pp. S518-S518(3) (3), S518 - S518, Japanese

  International conference proceedings


• 前十字靱帯不全膝における膝最大伸展位での脛骨前方偏位の検討

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2011, 中部日本整形外科災害外科学会雑誌, 54巻, 春季学会, pp. 74-74(3) (3), S518 - S518, Japanese

  International conference proceedings


• 人工膝全関節置換術後の膝関節位置覚における後十字靱帯温存の影響

  Kubo Seiji, Kurosaka Masahiro, Kuroda Ryosuke

  Mar. 2011, 日本整形外科学会雑誌, 85巻, 3号, pp. S733-S733, Japanese

  International conference proceedings


• 人工膝関節置換術の術中軟部組織バランスが術後膝屈曲可動域に及ぼす影響

  Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2011, 日本整形外科学会雑誌, 85巻, 3号, pp. S695-S695, Japanese

  International conference proceedings


• 解剖学的二重束ACL再建術後のEndoButton経時的位置変化について MDCTによる評価

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2011, 日本整形外科学会雑誌, 85巻, 3号, pp. S466-S466(3) (3), S466 - S466, Japanese

  International conference proceedings


• 解剖学的二重束ACL再建術後におけるEndoButton経時的位置変化についての評価検討

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  関西関節鏡・膝研究会, Mar. 2011, 関西関節鏡・膝研究会プログラム・演題抄録23回, 巻, , pp. 24-24, 24 - 24, Japanese

  International conference proceedings


• Regulation of p38 MAPK phosphorylation inhibits chondrocyte apoptosis in response to heat stress or mechanical stress

  Ken Takebe, Takayuki Nishiyama, Shinya Hayashi, Shingo Hashimoto, Takaaki Fujishiro, Noriyuki Kanzaki, Kohei Kawakita, Kenjiro Iwasa, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2011, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 27(3) (3), 329 - 335, English

  Scientific journal


• A prospective randomised study of anatomical single-bundle versus double-bundle anterior cruciate ligament reconstruction: quantitative evaluation using an electromagnetic measurement system

  Daisuke Araki, Ryosuke Kuroda, Seiji Kubo, Norifumi Fujita, Katsumasa Tei, Koji Nishimoto, Yuichi Hoshino, Takehiko Matsushita, Tomoyuki Matsumoto, Koki Nagamune, Masahiro Kurosaka

  Mar. 2011, INTERNATIONAL ORTHOPAEDICS, 35(3) (3), 439 - 446, English

  [Refereed]

  Scientific journal


• 膝前十字靱帯損傷の治療 過去30年を振り返る BTBとハムストリングの素材特性を生かしたACL再建術の適応と手技

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  Feb. 2011, 日本整形外科学会雑誌, 85巻, 2号, pp. S223-S223, Japanese

  International conference proceedings


• 膝前十字靱帯再建術の課題と将来戦略 基礎的研究を含めて

  Kuroda Ryosuke, Kurosaka Masahiro

  Feb. 2011, 日本整形外科学会雑誌, 85巻, 2号, pp. S289-S289, Japanese

  International conference proceedings


• T1 ρmappingとT2mappingを使用した膝関節軟骨変性の評価

  Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Feb. 2011, 日本医学放射線学会学術集会抄録集, 巻, 70回, pp. S255-S255, Japanese

  International conference proceedings


• Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months

  Shigeyuki Wakitani, Takahiro Okabe, Shuji Horibe, Tomoki Mitsuoka, Masanobu Saito, Tsuyoshi Koyama, Masashi Nawata, Keiji Tensho, Hiroyuki Kato, Kota Uematsu, Ryosuke Kuroda, Masahiro Kurosaka, Shinichi Yoshiya, Koji Hattori, Hajime Ohgushi

  Feb. 2011, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 5(2) (2), 146 - 150, English

  Scientific journal


• 3T-MRIを用いた変形性膝関節症に対する薬物療法の治療効果判定

  Kubo Seiji, Kuroda Ryosuke

  Feb. 2011, 日本医学放射線学会学術集会抄録集, 巻, 70回, pp. S327-S327, Japanese

  International conference proceedings


• 3T-MRIを用いた軟骨変性の調査 変形性膝関節症に対する関節内ヒアルロン酸注入およびNSAIDs内服による前向き介入臨床試験

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  Feb. 2011, 日本整形外科学会雑誌, 85巻, 2号, pp. S63-S63, Japanese

  International conference proceedings


• 2D-3D matching of fluoroscopy and MDCT image during manual tests based on anatomical knowledge

  K. Nagamune, Y. Uozumi, S. Oka, H. Sasaki, D. Araki, S. Kubo, R. Kuroda, M. Kurosaka

  2011, Proceedings of the 2011 International Conference on Image Processing, Computer Vision, and Pattern Recognition, IPCV 2011, 1, 488 - 494, English

  International conference proceedings


• Six degree of freedom calculation based on principal component analysis for the knee joint in MDCT image

  Yosuke Uozumi, Kouki Nagamune, Takehiko Matsushita, Seiji Kubo, Ryosuke Kuroda, Masahiro Kurosaka

  2011, IEEE International Conference on Fuzzy Systems, 1436 - 1441, English

  [Refereed]

  International conference proceedings


• A Quantitative Measurement System of Endpoint during Lachman test with Force Sensor

  Shogo Kawaguchi, Kouki Nagamune, Daisuke Araki, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2011, IEEE INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS (FUZZ 2011), 1453 - 1458, English

  [Refereed]

  International conference proceedings


• A Development of Navigation System for Mosaic Plasty using Electromagnetic Sensor

  Takayasu Toyoshima, Kouki Nagamune, Daisuke Araki, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2011, IEEE INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS (FUZZ 2011), 1447 - 1452, English

  [Refereed]

  International conference proceedings


• An Analysis Method of Femur and Patellar for Patellar Subluxation Diagnosis using MDCT Image

  Kouki Nagamune, Shinya Oka, Hiroshi Sasaki, Daisuke Araki, Tomoyuki Matsumoto, Takehiko Matsushita, Seiji Kubo, Ryosuke Kuroda, Masahiro Kurosaka

  2011, 2011 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN, AND CYBERNETICS (SMC), 764 - 768, English

  [Refereed]

  International conference proceedings


• Local Transplantation of G-CSF-Mobilized CD34(+) Cells in a Patient With Tibial Nonunion: A Case Report

  Ryosuke Kuroda, Tomoyuki Matsumoto, Masahiko Miwa, Atsuhiko Kawamoto, Yutaka Mifune, Tomoaki Fukui, Yohei Kawakami, Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Taro Shoji, Tomoya Kuroda, Miki Horii, Ayumi Yokoyama, Takayuki Ono, Yasushi Koibuchi, Shin Kawamata, Masanori Fukushima, Masahiro Kurosaka, Takayuki Asahara

  2011, CELL TRANSPLANTATION, 20(9) (9), 1491 - 1496, English

  [Refereed]

  Scientific journal


• 特発性膝関節血症の3症例

  Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Jan. 2011, 中部日本整形外科災害外科学会雑誌, 54巻, 1号, pp. 198-198(1) (1), 198 - 198, Japanese

  International conference proceedings


• Thermal necrosis after simultaneous tibial osteotomy and total knee arthroplasty using press-fit extension-stem

  Kazunari Ishida, Nobuhiro Tsumura, Koji Takayama, Naomasa Fukase, Atsushi Kitagawa, Takaaki Chin, Tetsuhiro Iguchi, Tomoyuki Matsumoto, Seiji Kubo, Masahiro Kurosaka, Ryosuke Kuroda

  Jan. 2011, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 19(1) (1), 112 - 114, English

  Scientific journal


• Double ACL sign 内側半月板バケツ柄状損傷の1例

  Matsushita Takehiko, Kuroda Ryosuke, Kubo Seiji, Matsumoto Tomoyuki, Kurosaka Masahiro

  Jan. 2011, スポーツ傷害, 16, 13, Japanese

  Research society


• Anatomic double-bundle anterior crucial ligament reconstruction with G-ST

  Ryosuke Kuroda, Takehiko Matsushita

  Humana Press Inc., 2011, Current Reviews in Musculoskeletal Medicine, 4(2) (2), 57 - 64, English

  [Refereed]

  Scientific journal


• ライフサイエンス分野を拓く高分子バイオマテリアルの最前線 高分子ハイドロゲルを用いた整形外科領域の再生医療研究

  Kuroda Ryosuke, Kubo Seiji, Matsushita Takehiko, Matsumoto Tomoyuki, Kurosaka Masahiro

  Nov. 2010, 日本バイオマテリアル学会大会予稿集32回, 46, Japanese

  Research society


• Femoral component placement changes soft tissue balance in posterior-stabilized total knee arthroplasty

  Hirotsugu Muratsu, Tomoyuki Matsumoto, Seiji Kubo, Akihiro Maruo, Hidetoshi Miya, Masahiro Kurosaka, Ryosuke Kuroda

  Nov. 2010, CLINICAL BIOMECHANICS, 25(9) (9), 926 - 930, English

  Scientific journal


• 運動器疾患に対する内視鏡下手術のupdate 膝関節の関節鏡下手術

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  Oct. 2010, 日本内視鏡外科学会雑誌, 15巻, 7号, pp. 261-261, Japanese

  International conference proceedings


• スポーツ愛好家の変形性膝関節症に対し骨軟骨柱移植術を併用した高位脛骨骨切り術を施行した2症例

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (一社)日本臨床スポーツ医学会, Oct. 2010, 日本臨床スポーツ医学会誌, 18巻, 4号, pp. S186-S186(4) (4), S186 - S186, Japanese

  International conference proceedings


• X線画像による膝蓋骨脱臼のスクリーニング

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (一社)日本臨床スポーツ医学会, Oct. 2010, 日本臨床スポーツ医学会誌, 18巻, 4号, pp. S179-S179(4) (4), S179 - S179, Japanese

  International conference proceedings


• Bone Regeneration Properties of Granulocyte Colony-Stimulating Factor via Neovascularization and Osteogenesis

  Kazunari Ishida, Tomoyuki Matsumoto, Ken Sasaki, Yutaka Mifune, Katsumasa Tei, Seiji Kubo, Takehiko Matsushita, Koji Takayama, Toshihiro Akisue, Yasuhiko Tabata, Masahiro Kurosaka, Ryosuke Kuroda

  Oct. 2010, TISSUE ENGINEERING PART A, 16(10) (10), 3271 - 3284, English

  [Refereed]

  Scientific journal


• Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing

  Tomoyuki Matsumoto, Masaaki Ii, Hiromi Nishimura, Taro Shoji, Yutaka Mifune, Atsuhiko Kawamoto, Ryosuke Kuroda, Tomoaki Fukui, Yohei Kawakami, Tomoya Kuroda, Sang Mo Kwon, Hiroto Iwasaki, Miki Horii, Ayumi Yokoyama, Akira Oyamada, Sang Yang Lee, Shinya Hayashi, Masahiro Kurosaka, Satoshi Takaki, Takayuki Asahara

  Sep. 2010, JOURNAL OF EXPERIMENTAL MEDICINE, 207(10) (10), 2207 - 2223, English

  Scientific journal


• CT-free navigation systemを使用したTKAの術後短期臨床成績

  Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2010, 中部日本整形外科災害外科学会雑誌, 53巻, 秋季学会, pp. 159-159, Japanese

  International conference proceedings


• 磁気センサーを用いた膝関節不安定性計測の試み

  小林 龍生, 村田 賢二, 田村 吏沙, 三尾 健介, 金子 大毅, 長宗 高樹, 黒田 良祐, 黒坂 昌弘

  (一社)日本整形外科スポーツ医学会, Aug. 2010, 日本整形外科スポーツ医学会雑誌, 30(4) (4), 372 - 372, Japanese


• 軟骨細胞においてオートファジーはOA関連遺伝子の発現を調節している

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  Aug. 2010, 日本整形外科学会雑誌, 84巻, 8号, pp. S1233-S1233, Japanese

  International conference proceedings


• 低出力超音波パルスはBMP-7によるヒト骨折血腫由来細胞の骨分化を促進する

  Ri Soryo, Niikura Takahiro, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2010, 日本整形外科学会雑誌, 84巻, 8号, pp. S1119-S1119(8) (8), Japanese

  International conference proceedings


• 長寿因子Sirt1がヒト椎間板髄核細胞の細胞活性に与える影響の検討

  Nishida Kotaro, Maeno Koichiro, Kuroda Ryosuke, Doita Minoru, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1252 - S1252, Japanese

  [Refereed]

  International conference proceedings


• 体外増幅ヒトCD34陽性細胞を用いた難治性骨折に対する新規治療法の開発

  Kuroda Ryosuke, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84巻, 8号, pp. S1083-S1083(8) (8), S1083 - S1083, Japanese

  International conference proceedings


• 基礎研究をもとにした骨折治療の新しい流れ 末梢血CD34陽性細胞による骨・血管再生療法

  Matsumoto Tomoyuki, Niikura Takahiro, Ri Soryo, Kurosaka Masahiro, Kuroda Ryosuke

  (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84巻, 8号, pp. S1109-S1109(8) (8), S1109 - S1109, Japanese

  International conference proceedings


• 温熱ストレスによる軟骨細胞アポトーシスにおけるp38のリン酸化の関与

  Nishiyama Takayuki, Fujishiro Takaaki, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2010, 日本整形外科学会雑誌, 84巻, 8号, pp. S1234-S1234, Japanese

  [Refereed]

  International conference proceedings


• ラット大腿骨偽関節モデルにおけるG-CSF動員CD34陽性細胞移植の治療効果の検討

  Niikura Takahiro, Kuroda Ryosuke, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84巻, 8号, pp. S1083-S1083(8) (8), S1083 - S1083, Japanese

  International conference proceedings


• SIRT1の過剰発現はヒト軟骨細胞においてIL-1β誘導による変形性関節症性様の遺伝子発現変化を抑制する

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  Aug. 2010, 日本整形外科学会雑誌, 84巻, 8号, pp. S1057-S1057, Japanese

  International conference proceedings


• 前十字靱帯再建術における大腿骨骨孔位置とpivot shift testとの関係

  佐々木 謙, 山口 基, 中山 寛, 吉矢 晋一, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2010, JOSKAS, 35(4) (4), 192 - 192, Japanese


• 解剖学的2重束前十字靱帯再建術の大腿骨骨孔作製方法 Inside-out法でresident's ridgeの後方に骨孔を作製する際の問題点

  中山 寛, 山口 基, 佐々木 謙, 吉矢 晋一, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2010, JOSKAS, 35(4) (4), 192 - 192, Japanese


• 当科で施行したACL augmentationの臨床成績

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2010, JOSKAS, 35巻, 4号, pp. 188-188(4) (4), 188 - 188, Japanese

  International conference proceedings


• 術中軟部バランスがCR-TKAの術後膝屈曲可動域に及ぼす影響について

  Kubo Seiji, Kurosaka Masahiro, Kuroda Ryosuke

  Jun. 2010, JOSKAS, 35巻, 4号, pp. 42-42, Japanese

  International conference proceedings


• 解剖学的2重束前十字靱帯再建術の術後成績

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2010, JOSKAS, 35巻, 4号, pp. 205-205(4) (4), 205 - 205, Japanese

  International conference proceedings


• X線画像による膝蓋骨脱臼のスクリーニング

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  Jun. 2010, JOSKAS, 35巻, 4号, pp. 357-357, Japanese

  International conference proceedings


• Nondestructive Evaluation of Cell Numbers in Bone Marrow Stromal Cell/beta-Tricalcium Phosphate Composites Using Ultrasound

  Keisuke Oe, Masahiko Miwa, Kouki Nagamune, Yoshitada Sakai, Sang Yang Lee, Takahiro Niikura, Takashi Iwakura, Takumi Hasegawa, Nao Shibanuma, Yutaka Hata, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2010, TISSUE ENGINEERING PART C-METHODS, 16(3) (3), 347 - 353, English

  [Refereed]

  Scientific journal


• Navigation CR TKAでのtibia first手技を用いたDependent法による軟部組織バランス

  Matsumoto Tomoyuki, Kubo Seiji, Kurosaka Masahiro, Kuroda Ryosuke

  Jun. 2010, JOSKAS, 35巻, 4号, pp. 36-36, Japanese

  International conference proceedings


• ACL再建術の長期成績 再断裂防止に向けた展望 ACL損傷に対する治療 今後の展望

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2010, JOSKAS, 35巻, 4号, pp. 10-10(4) (4), 10 - 10, Japanese

  International conference proceedings


• ACL再建術における骨孔の経時的変化

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2010, JOSKAS, 35巻, 4号, pp. 19-19(4) (4), 19 - 19, Japanese

  International conference proceedings


• Acetabular Development in the Contralateral Hip in Patients with Unilateral Developmental Dysplasia of the Hip

  D. Kobayashi, S. Satsuma, R. Kuroda, M. Kurosaka

  Jun. 2010, JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 92A(6) (6), 1390 - 1397, English

  Scientific journal


• 3T-MRIを用いた、T2 mappingによる関節軟骨変性の定量的評価 病理組織像との比較

  Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Jun. 2010, JOSKAS, 35巻, 4号, pp. 151-151, Japanese

  International conference proceedings


• レムナントを残した前十字靱帯再建術の問題点

  Kuroda Ryosuke, Kurosaka Masahiro

  THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, May 2010, 中部日本整形外科災害外科学会雑誌, 53巻, 3号, pp. 525-526(3) (3), 525 - 526, Japanese

  [Refereed]

  Scientific journal


• Local transplantation of human multipotent adipose-derived stem cells accelerates fracture healing via enhanced osteogenesis and angiogenesis

  Taro Shoji, Masaaki Ii, Yutaka Mifune, Tomoyuki Matsumoto, Atsuhiko Kawamoto, Sang-Mo Kwon, Tomoya Kuroda, Ryosuke Kuroda, Masahiro Kurosaka, Takayuki Asahara

  Apr. 2010, Laboratory Investigation, 90(4) (4), 637 - 649, English

  Scientific journal


• 膝前十字靱帯損傷の徒手検査における検者間での違い アンケート調査と電磁センサーシステムを用いた計測より

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (公社)日本整形外科学会, Apr. 2010, 日本整形外科学会雑誌, 84巻, 4号, pp. S263-S263(4) (4), S263 - S263, Japanese

  International conference proceedings


• 陳旧性前十字靱帯不全膝における膝最大伸展位での脛骨前方偏位の検討

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (公社)日本整形外科学会, Apr. 2010, 日本整形外科学会雑誌, 84巻, 4号, pp. S591-S591(4) (4), S591 - S591, Japanese

  International conference proceedings


• 3T-MRIにおける関節軟骨変性の定量的評価 病理組織像との比較

  Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Apr. 2010, 日本整形外科学会雑誌, 84巻, 4号, pp. S545-S545, Japanese

  International conference proceedings


• 外側半月板前節損傷の検討

  中山 寛, 佐々木 謙, 山口 基, 吉矢 晋一, 荒木 大輔, 黒田 良祐, 黒坂 昌弘

  関西関節鏡・膝研究会, Mar. 2010, 関西関節鏡・膝研究会プログラム・演題抄録, 22回, 29 - 29, Japanese


• 変形性膝関節症の介入研究の短期成績 変形性膝関節症に対する踵の衝撃吸収性を持つ靴の効果

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  Mar. 2010, 日本整形外科学会雑誌, 84巻, 3号, pp. S4-S4, Japanese

  International conference proceedings


• 長寿因子Sirt1のヒト椎間板髄核細胞における発現と細胞活性に与える影響の検討

  Nishida Kotaro, Maeno Koichiro, Kuroda Ryosuke, Kurosaka Masahiro, Doita Minoru

  (一社)日本脊椎脊髄病学会, Mar. 2010, Journal of Spine Research, 1(3) (3), 399 - 399, Japanese

  [Refereed]

  International conference proceedings


• 前十字靱帯損傷膝の異なる回旋ストレスに対するKinematicsの変化と回旋角度による評価

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2010, JOSKAS, 35巻, 1号, pp. 82-83(1) (1), 82 - 83, Japanese

  [Refereed]

  Scientific journal


• 前十字靱帯再建術後の膝伸展制限の変化

  Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2010, JOSKAS, 35巻, 1号, pp. 112-113, Japanese

  [Refereed]

  Scientific journal


• 前十字靱帯に関するエキスパート実技 膝前十字靱帯に関する徒手検査の標準化と今後の展望

  Kurosaka Masahiro, Kuroda Ryosuke, Kubo Seiji

  (公社)日本整形外科学会, Mar. 2010, 日本整形外科学会雑誌, 84巻, 3号, pp. S184-S184(3) (3), S184 - S184, Japanese

  International conference proceedings


• 人工膝関節置換術における軟部組織バランス PS型TKAとCR型TKAでの比較

  Matsumoto Tomoyuki, Kubo Seiji, Kurosaka Masahiro, Kuroda Ryosuke

  Mar. 2010, 日本整形外科学会雑誌 84巻, 84巻, 3号, pp. S140-S140, Japanese

  International conference proceedings


• 人工膝関節置換術における最小侵襲手技が軟部組織バランスに及ぼす影響

  Matsumoto Tomoyuki, Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2010, JOSKAS, 35巻, 1号, pp. 34-35, Japanese

  [Refereed]

  Scientific journal


• 小皮切TKAでの膝蓋骨外側シフトが軟部組織バランスに与える影響について

  Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2010, JOSKAS, 35巻, 1号, pp. 20-21(1) (1), 20 - 21, Japanese

  [Refereed]

  Scientific journal


• Revision ACL再建術を施行した症例の検討

  Kuroda Ryosuke, Kubo Seiji, Matsumoto Tomoyuki, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2010, JOSKAS, 35巻, 1号, pp. 88-89(1) (1), 88 - 89, Japanese

  [Refereed]

  Scientific journal


• Puddu plateを用いたopen-wedge高位脛骨骨切り術の治療成績

  Kuroda Ryosuke, Matsumoto Tomoyuki, Kubo Seiji, Kurosaka Masahiro

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2010, JOSKAS, 35巻, 1号, pp. 184-185(1) (1), 184 - 185, Japanese

  [Refereed]

  Scientific journal


• 3T-MRIにおける関節軟骨変性の定性的、定量的評価 病理組織像との比較

  Kubo Seiji, Kuroda Ryosuke, Matsumoto Tomoyuki, Sugimura Kazuro, Kurosaka Masahiro

  Mar. 2010, JOSKAS, 35巻, 1号, pp. 4-5(1) (1), 4 - 5, Japanese

  [Refereed]

  Scientific journal


• T2マッピングによる関節軟骨の変性の評価 病理組織所見との対比

  Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Feb. 2010, 日本医学放射線学会学術集会抄録集, 巻, 69回, pp. S356-S357, Japanese

  International conference proceedings


• Motion analysis of knee joint during Lachman test from fluoroscopy by fuzzy inference

  Kouki Nagamune, Hiroshi Sasaki, Daisuke Araki, Seiji Kubo, Ryosuke Kuroda, Masahiro Kurosaka

  2010, 4th International Symposium on Computational Intelligence and Industrial Applications, ISCIIA 2010, 41 - 46, English

  International conference proceedings


• An analysis method of EndoButton position with registration in MDCT images after anterior cruciate ligament reconstruction

  Yosuke Ozumi, Kouki Nagamune, Daisuke Araki, Seiji Kubo, Ryosuke Kuroda, Masahiro Kurosaka

  2010, 2010 World Automation Congress, WAC 2010, English

  International conference proceedings


• Automated Determination Method of Tibial Bone Coordinate System for Analysing Bone Tunnel Trans-Position after Anterior Cruciate Ligament Reconstruction from a Knee MDCT Image

  K. Nagamune, D. Araki, S. Kubo, R. Kuroda, M. Kurosaka

  2010, 2010 IEEE INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS (FUZZ-IEEE 2010), English

  [Refereed]

  International conference proceedings


• An Analysis Method of Surface Profile for Cylindrical Osteochondral Grafts of the Knee

  Kouki Nagamune, Daisuke Araki, Seiji Kubo, Ryosuke Kuroda, Masahiro Kurosaka

  2010, IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN AND CYBERNETICS (SMC 2010), English

  [Refereed]

  International conference proceedings


• 臨床研究の活性化と再生医療産業化の促進 骨・関節領域（整形外科、歯科・口腔外科）の実施者からの提言

  Kuroda Ryosuke

  メディカルレビュー社, 2010, 再生医療, 9巻, 3, pp. 393-400(3) (3), 393 - 400, Japanese

  Scientific journal


• Pneumocephalus associated with cerebrospinal fluid fistula as a complication of spinal surgery: A case report

  Ken Sasaki, Tomoyuki Matsumoto, Toshiyuki Mizuno, Shinichi Ikuta, Toshihiro Akisue, Hiroyuki Fujioka, Minoru Doita, Masahiro Kurosaka, Ryosuke Kuroda

  Hindawi Limited, 2010, Case Reports in Medicine, 2010, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 骨端線閉鎖前の反復性膝蓋骨脱臼に対するsuture anchorを用いたMPFL再建術

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  スポーツ傷害フォーラム, Jan. 2010, スポーツ傷害, 15巻, , pp. 8-8, 8 - 8, Japanese

  International conference proceedings


• 関節リウマチ患者における術後感染、創治癒遅延 メソトレキサート、生物学的製剤はリスクとなるのか

  Kuroda Ryosuke, Nishiyama Takayuki, Doita Minoru, Kurosaka Masahiro

  Jan. 2010, 中部日本整形外科災害外科学会雑誌, 53巻, 1号, pp. 179-180(1) (1), 179 - 180, Japanese

  [Refereed]

  Scientific journal


• 特発性膝関節血症の2症例

  Kuroda Ryosuke, Kubo Seiji, Akisue Toshihiro, Kurosaka Masahiro

  Nov. 2009, 中部日本整形外科災害外科学会雑誌, 52巻, 6号, pp. 1466-1467, Japanese

  [Refereed]

  Scientific journal


• Factors Affecting Prosthetic Rehabilitation Outcomes in Amputees of Age 60 Years and Over

  S. Hamamura, T. Chin, R. Kuroda, T. Akisue, T. Iguchi, H. Kohno, A. Kitagawa, N. Tsumura, M. Kurosaka

  Nov. 2009, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 37(6) (6), 1921 - 1927, English

  Scientific journal


• Bilateral double-layered lateral meniscus: a report of two cases

  Koji Takayama, Ryosuke Kuroda, Tomoyuki Matsumoto, Daisuke Araki, Norifumi Fujita, Katsumasa Tei, Yutaka Mifune, Keisuke Oe, Takehiko Matsushita, Seiji Kubo, Keisuke Kinoshita, Akio Matsumoto, Masahiro Kurosaka

  Nov. 2009, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 17(11) (11), 1336 - 1339, English

  [Refereed]

  Scientific journal


• サッカー選手に生じた外側半月板前節損傷の検討

  中山 寛, 佐々木 謙, 山口 基, 吉矢 晋一, 黒田 良祐, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2009, 日本臨床スポーツ医学会誌, 17(4) (4), S118 - S118, Japanese


• 変形性膝関節症を呈するアスリートに対し高位脛骨骨切り術を施行した2症例

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (一社)日本臨床スポーツ医学会, Oct. 2009, 日本臨床スポーツ医学会誌, 17巻, 4号, pp. S151-S151(4) (4), S151 - S151, Japanese

  International conference proceedings


• 大腿骨内顆軟骨損傷に対し骨軟骨柱移植術を行い試合復帰し得たプロ野球選手の1例

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (一社)日本臨床スポーツ医学会, Oct. 2009, 日本臨床スポーツ医学会誌, 17巻, 4号, pp. S118-S118(4) (4), S118 - S118, Japanese

  International conference proceedings


• 【膝前十字靱帯再建術】 ACL損傷に対する再建術式と治療成績 自家骨付き膝蓋腱を用いた一束再建術の長期成績

  Kuroda Ryosuke, Kurosaka Masahiro

  Oct. 2009, Orthopaedics, 22巻, 11号, pp. 15-19, Japanese

  Scientific journal


• スポーツに関連した関節症の治療 アスリートにおける靱帯/半月損傷後2次性変形性膝関節症に対する治療

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  Oct. 2009, 日本関節病学会誌, 28巻, 3号, pp. 388-388, Japanese

  International conference proceedings


• エビデンスに基づく前十字靱帯損傷の治療 膝不安定性の評価法 前十字靱帯損傷膝の診断・評価

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (一社)日本臨床スポーツ医学会, Oct. 2009, 日本臨床スポーツ医学会誌, 17巻, 4号, pp. S82-S82(4) (4), S82 - S82, Japanese

  International conference proceedings


• レムナントを温存した前十字靱帯(ACL)再建術の問題点

  中山 寛, 山口 基, 佐々木 謙, 吉矢 晋一, 黒田 良祐, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Sep. 2009, 中部日本整形外科災害外科学会雑誌, 52(秋季学会) (秋季学会), 34 - 34, Japanese


• 人工膝関節置換術後の静脈血栓症予防におけるフォンダパリヌクスとエノキサパリンナトリウムの有用性の比較

  Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2009, 中部日本整形外科災害外科学会雑誌, 52巻, 秋季学会, pp. 128-128, Japanese

  [Refereed]

  International conference proceedings


• 若年発症ステロイド誘発性大腿骨内顆骨壊死に対してモザイクプラスティを施行した3例

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  Sep. 2009, 中部日本整形外科災害外科学会雑誌, 52巻, 秋季学会, pp. 60-60, Japanese

  International conference proceedings


• 関節リウマチ患者における術後感染、治癒遅延 メソトレキサート、生物学的製剤はリスクとなるのか

  Kuroda Ryosuke, Nishiyama Takayuki, Doita Minoru, Kurosaka Masahiro

  Sep. 2009, 中部日本整形外科災害外科学会雑誌, 52巻, 秋季学会, pp. 112-112, Japanese

  [Refereed]

  International conference proceedings


• 解剖学的2重束前十字靱帯再建術の術式とその問題点

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Sep. 2009, 中部日本整形外科災害外科学会雑誌, 52巻, 秋季学会, pp. 34-34(秋季学会) (秋季学会), 34 - 34, Japanese

  International conference proceedings


• The effect of intra-operative knee flexion angle on determination of graft location in the anatomic double-bundle anterior cruciate ligament reconstruction

  Yuichi Hoshino, Kouki Nagamune, Masayoshi Yagi, Daisuke Araki, Koji Nishimoto, Seiji Kubo, Doita Minoru, Masahiro Kurosaka, Ryosuke Kuroda

  Sep. 2009, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 17(9) (9), 1052 - 1060, English

  [Refereed]

  Scientific journal


• SIRT1 Regulation of Apoptosis of Human Chondrocytes

  Koji Takayama, Kazunari Ishida, Takehiko Matsushita, Norifumi Fujita, Shinya Hayashi, Ken Sasaki, Katsumasa Tei, Seiji Kubo, Tomoyuki Matsumoto, Hiroyuki Fujioka, Masahiro Kurosaka, Ryosuke Kuroda

  Sep. 2009, ARTHRITIS AND RHEUMATISM, 60(9) (9), 2731 - 2740, English

  [Refereed]

  Scientific journal


• Antibiotic cement screw for postoperative infection after gamma nailing

  Mitsuaki Noda, Yasuhiro Saegusa, Yoshiyuki Takakura, Ryosuke Kuroda, Minoru Doita

  Aug. 2009, Orthopedics, 32(8) (8), 608, English

  [Refereed]

  Scientific journal


• 変形性膝関節症の病因における寿命因子SIRT1の影響について

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  Aug. 2009, 日本整形外科学会雑誌, 83巻, 8号, pp. S1183-S1183, Japanese

  International conference proceedings


• 変形性膝関節症に対する第3世代ACI(Autologous Chondrocyte Implantation)を用いた治療

  Kubo Seiji, Kurosaka Masahiro, Kuroda Ryosuke

  (公社)日本整形外科学会, Aug. 2009, 日本整形外科学会雑誌, 83巻, 8号, pp. S1312-S1312(8) (8), S1312 - S1312, Japanese

  International conference proceedings


• 膝前十字靱帯部分断裂症例の動作解析 三次元電磁気計測システムを用いた定量的評価

  Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2009, 日本整形外科学会雑誌, 83巻, 8号, pp. S1222-S1222(8) (8), S1222 - S1222, Japanese

  International conference proceedings


• 糖尿病マウス骨折治癒遅延モデルにおける胎生期器官形成関連因子Sonic hedgehogシグナル再構築による骨折治療効果の検討

  Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2009, 日本整形外科学会雑誌, 83巻, 8号, pp. S1143-S1143, Japanese

  International conference proceedings


• 人工膝関節置換術における軟部組織バランス PS型TKAとCR型TKAでの比較

  Kubo Seiji, Kurosaka Masahiro, Kuroda Ryosuke

  Aug. 2009, 日本整形外科学会雑誌, 83巻, 8号, pp. S1236-S1236, Japanese

  International conference proceedings


• 滑膜・膝蓋下脂肪体由来間葉系前駆細胞における軟骨分化誘導後のsuperficial zone protein(SZP)産生能の比較検討

  Niikura Takahiro, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2009, 日本整形外科学会雑誌, 83巻, 8号, pp. S1310-S1310, Japanese

  International conference proceedings


• ラット大腿骨難治性骨折モデルに対するG-CSF動員単核球細胞移植の治療効果の検討

  Kurosaka Masahiro, Kuroda Ryosuke

  (公社)日本整形外科学会, Aug. 2009, 日本整形外科学会雑誌, 83巻, 8号, pp. S1238-S1238(8) (8), S1238 - S1238, Japanese

  International conference proceedings


• ストレスによる軟骨細胞アポトーシスにおけるp38のリン酸化の関与

  Nishiyama Takayuki, Fujishiro Takaaki, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2009, 日本整形外科学会雑誌, 83巻, 8号, pp. S1135-S1135, Japanese

  [Refereed]

  International conference proceedings


• SIRT1はヒト軟骨細胞のアポトーシスをミトコンドリア経路を介して制御する

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (公社)日本整形外科学会, Aug. 2009, 日本整形外科学会雑誌, 83巻, 8号, pp. S1183-S1183(8) (8), S1183 - S1183, Japanese

  International conference proceedings


• Role of p53 in Human Chondrocyte Apoptosis in Response to Shear Strain

  Shingo Hashimoto, Takayuki Nishiyama, Shinya Hayashi, Takaaki Fujishiro, Ken Takebe, Noriyuki Kanzaki, Ryosuke Kuroda, Masahiro Kurosaka

  Aug. 2009, ARTHRITIS AND RHEUMATISM, 60(8) (8), 2340 - 2349, English

  [Refereed]

  Scientific journal


• 【アスリートの前十字靱帯損傷 再建術後のリハビリテーション最前線】 膝前十字靱帯のバイオメカニクス 三次元電磁気計測システムを用いたPivot shift testの解析

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (株)文光堂, Jul. 2009, 臨床スポーツ医学, 26巻, 7号, pp. 757-760(7) (7), 757 - 760, Japanese

  Scientific journal


• 習慣性膝蓋骨脱臼に対し内側膝蓋大腿靱帯(MPFL)再建術を施行した2例

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (株)メジカルビュー社, Jun. 2009, 関節外科, 28巻, 6号, pp. 760-764(6) (6), 760 - 764, Japanese

  [Refereed]

  Scientific journal


• The intra-operative joint gap in cruciate-retaining compared with posterior-stabilised total knee replacement

  T. Matsumoto, R. Kuroda, S. Kubo, H. Muratsu, K. Mizuno, M. Kurosaka

  Apr. 2009, JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 91B(4) (4), 475 - 480, English

  [Refereed]

  Scientific journal


• Soft Tissue Balance Measurement in Posterior-Stabilized Total Knee Arthroplasty With a Navigation System

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Nobuhiro Tsumura, Kiyonori Mizuno, Masahiro Kurosaka, Ryosuke Kuroda

  Apr. 2009, JOURNAL OF ARTHROPLASTY, 24(3) (3), 358 - 364, English

  [Refereed]

  Scientific journal


• 複合靱帯損傷膝における後外側支持機構損傷に対する一次修復術の検討

  中山 寛, 山口 基, 八木 正義, 吉矢 晋一, 黒田 良祐, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2009, 日本整形外科学会雑誌, 83(3) (3), S488 - S488, Japanese


• 両側血友病性膝関節症に対して全人工関節置換術を施行した1例

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  Mar. 2009, 中部日本整形外科災害外科学会雑誌, 52巻, 春季学会, pp. 211-211, Japanese

  International conference proceedings


• A palmar fracture-dislocation of the proximal interphalangeal joint of the middle finger caused by bowling: A case report

  Tomoaki Fukui, Kazunari Ishida, Taro Shoji, Kenjiro Ito, Shinji Matsushima, Ryosuke Kuroda, Hiroyuki Fujioka, Masahiro Kurosaka, Kazuya Yoshida

  Mar. 2009, JOURNAL OF SPORTS SCIENCE AND MEDICINE, 8(1) (1), 144 - 147, English

  [Refereed]

  Scientific journal


• Analysis of the graft bending angle at the femoral tunnel aperture in anatomic double bundle anterior cruciate ligament reconstruction: a comparison of the transtibial and the far anteromedial portal technique

  Koji Nishimoto, Ryosuke Kuroda, Kiyonori Mizuno, Yuichi Hoshino, Kouki Nagamune, Seiji Kubo, Masayoshi Yagi, Motoi Yamaguchi, Shinichi Yoshiya, Masahiro Kurosaka

  Mar. 2009, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 17(3) (3), 270 - 276, English

  [Refereed]

  Scientific journal


• ACL再建術の生体力学 前十字靱帯再建前後の膝安定性評価 電磁気センサーによる三次元解析

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (公社)日本整形外科学会, Mar. 2009, 日本整形外科学会雑誌, 83巻, 3号, pp. S607-S607(3) (3), S607 - S607, Japanese

  International conference proceedings


• 膝前十字靱帯解剖学的一重束再建術と解剖学的二重束再建術の術後成績の検討 三次元電磁気計測システムを用いた定量的評価

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (公社)日本整形外科学会, Feb. 2009, 日本整形外科学会雑誌, 83巻, 2号, pp. S120-S120(2) (2), S120 - S120, Japanese

  International conference proceedings


• 膝前十字靱帯1ルート再建術を施行し得た部分断裂症例の動作解析 三次元電磁気計測システムでの定量的評価

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (公社)日本整形外科学会, Feb. 2009, 日本整形外科学会雑誌, 83巻, 2号, pp. S143-S143(2) (2), S143 - S143, Japanese

  International conference proceedings


• 反復性・習慣性膝蓋骨脱臼に対する半腱様筋腱を用いた内側膝蓋大腿靱帯(MPFL)再建術の臨床成績

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  (公社)日本整形外科学会, Feb. 2009, 日本整形外科学会雑誌, 83巻, 2号, pp. S221-S221(2) (2), S221 - S221, Japanese

  International conference proceedings


• TKA術前後の膝kinematicsと最大屈曲角度との関係

  Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Feb. 2009, 日本整形外科学会雑誌, 83巻, 2号, pp. S221-S221, Japanese

  International conference proceedings


• The effect of fibroblast growth factor-2 on autologous osteochondral transplantation

  Jun-ichi Nakayama, Hiroyuki Fujioka, Issei Nagura, Takeshi Kokubu, Takeshi Makino, Ryosuke Kuroda, Yasuhiko Tabata, Masahiro Kurosaka

  Feb. 2009, INTERNATIONAL ORTHOPAEDICS, 33(1) (1), 275 - 280, English

  [Refereed]

  Scientific journal


• Human Hypertrophic Nonunion Tissue Contains Mesenchymal Progenitor Cells with Multilineage Capacity In Vitro

  Takashi Iwakura, Masahiko Miwa, Yoshitada Sakai, Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Takumi Hasegawa, Ryosuke Kuroda, Hiroyuki Fujioka, Minoru Doita, Masahiro Kurosaka

  Feb. 2009, JOURNAL OF ORTHOPAEDIC RESEARCH, 27(2) (2), 208 - 215, English

  [Refereed]

  Scientific journal


• 3T-MR imaging of articular cartilage and repair treatment

  Masahiko Fujii, N. Aoyama, H. Kawamitsu, Y. Iwama, H. Goto, K. Sugimura, R. Kuroda, M. Kurosaka

  2009, Japanese Journal of Clinical Radiology, 54(2) (2), 277 - 286, Japanese

  Scientific journal


• An Evaluation Method of EndoButton Position in MDCT Image After Anterior Cruciate Ligament Reconstruction.

  Kouici Nagamune, Daisuke Araki, Koji Nishimot, Yuichi Hoshino, Seiji Kubo, Ryosuke Kuroda, Masahiro Kurosaka

  2009, 2009 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN AND CYBERNETICS (SMC 2009), VOLS 1-9, 1334 - +, English

  [Refereed]

  International conference proceedings


• Automated Extraction Method of Bone Tunnel after the Anterior Cruciate Ligament Reconstruction from a Knee MDCT Image by using Fuzzy Inference

  Kouki Nagamune, Daisuke Araki, Yuichi Hoshino, Seiji Kubo, Ryosuke Kuroda, Masahiro Kurosaka

  2009, 2009 IEEE INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS, VOLS 1-3, 933 - +, English

  [Refereed]

  International conference proceedings


• 大腿骨内顆軟骨損傷に対し骨軟骨柱移植術を行い試合復帰し得たプロ野球選手の1例

  Kuroda Ryosuke, Kubo Seiji, Kurosaka Masahiro

  スポーツ傷害フォーラム, Jan. 2009, スポーツ傷害, 14巻, , pp. 21-21, 21 - 21, Japanese

  Scientific journal


• 両側人工膝関節置換術後に発生した膝蓋骨外側脱臼に対し人工膝関節再置換術を施行した1例

  Kuroda Ryosuke, Kurosaka Masahiro

  THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, Nov. 2008, 中部日本整形外科災害外科学会雑誌, 51巻, 6号, pp. 1159-1160(6) (6), 1159 - 1160, Japanese

  [Refereed]

  Scientific journal


• 両側外側二層半月板の2例

  Kuroda Ryosuke, Kurosaka Masahiro

  (一社)日本臨床スポーツ医学会, Oct. 2008, 日本臨床スポーツ医学会誌, 16巻, 4号, pp. S135-S135(4) (4), S135 - S135, Japanese

  International conference proceedings


• 解剖学的二重束前十字靱帯再建術における大腿骨孔出口での移植腱の曲げ角度の検討 Far anteromedial portal techniqueとtranstibial techniqueの比較

  Kuroda Ryosuke, Kurosaka Masahiro

  (一社)日本臨床スポーツ医学会, Oct. 2008, 日本臨床スポーツ医学会誌, 16巻, 4号, pp. S184-S184(4) (4), S184 - S184, Japanese

  International conference proceedings


• 当科における半腱様筋腱を用いたMPFL再建術後の臨床成績

  Kuroda Ryosuke, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Sep. 2008, 中部日本整形外科災害外科学会雑誌, 51巻, 秋季学会, pp. 167-167(秋季学会) (秋季学会), 167 - 167, Japanese

  International conference proceedings


• 持続大腿神経ブロックによるTKA術後疼痛管理と機能回復促進

  Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2008, 中部日本整形外科災害外科学会雑誌, 51巻, 秋季学会, pp. 74-74, Japanese

  International conference proceedings


• Circulating endothelial/skeletal progenitor cells for bone regeneration and healing

  Tomoyuki Matsumoto, Ryosuke Kuroda, Yutaka Mifune, Atsuhiko Kawamoto, Taro Shoji, Masahiko Miwa, Takayuki Asahara, Masahiro Kurosaka

  Sep. 2008, BONE, 43(3) (3), 434 - 439, English

  [Refereed]

  Scientific journal


• 変形性膝関節症におけるヒト軟骨細胞の遺伝子発現や細胞増殖に対する寿命因子sirt1の影響

  Kurosaka Masahiro, Kuroda Ryosuke

  Aug. 2008, 日本整形外科学会雑誌, 82巻, 8号, pp. S1201-S1201, Japanese

  International conference proceedings


• 膝前十字靱帯由来血管幹細胞の分離と同定

  Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2008, 日本整形外科学会雑誌, 82巻, 8号, pp. S943-S943, Japanese

  International conference proceedings


• 膝蓋下脂肪体由来間質細胞における軟骨分化誘導後のsuperficial zone protein(SZP)産生の検討

  Miwa Masahiko, Niikura Takahiro, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2008, 日本整形外科学会雑誌, 82巻, 8号, pp. S1124-S1124, Japanese

  [Refereed]

  International conference proceedings


• 軟骨細胞における温熱刺激によるアポトーシスとp53の関連

  Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2008, 日本整形外科学会雑誌, 82巻, 8号, pp. S1101-S1101, Japanese

  International conference proceedings


• 長寿因子SIRT1はヒト軟骨細胞のアポトーシスを抑制する

  Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2008, 日本整形外科学会雑誌, 82巻, 8号, pp. S1103-S1103, Japanese

  International conference proceedings


• 骨折治癒過程におけるSDF-1/CXCR4シグナルによる骨新生、血管新生の制御

  Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2008, 日本整形外科学会雑誌, 82巻, 8号, pp. S1259-S1259, Japanese

  International conference proceedings


• 筋由来幹細胞を用いた遺伝子治療による変形性関節症治療の可能性

  Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2008, 日本整形外科学会雑誌, 82巻, 8号, pp. S1126-S1126, Japanese

  International conference proceedings


• 関節軟骨再生の臨床応用に向けて 温故知新 筋由来幹細胞を用いた軟骨再生

  Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2008, 日本整形外科学会雑誌, 82巻, 8号, pp. S891-S891, Japanese

  International conference proceedings


• 引っ張り刺激によるヒト軟骨細胞のアポトーシスとp53の関連

  Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2008, 日本整形外科学会雑誌, 82巻, 8号, pp. S1101-S1101, Japanese

  International conference proceedings


• ヒト脂肪組織由来多能性幹細胞移植の難治性骨折に対する治療効果の検討

  Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2008, 日本整形外科学会雑誌, 82巻, 8号, pp. S1260-S1260, Japanese

  International conference proceedings


• G-CSF動員ヒト末梢血CD34陽性細胞の局所移植による膝内側側副靱帯靱帯損傷の治癒促進

  Kurosaka Masahiro, Kuroda Ryosuke

  Aug. 2008, 日本整形外科学会雑誌, 82巻, 8号, pp. S944-S944, Japanese

  International conference proceedings


• G-CSF動員ヒト末梢血CD34陽性細胞による偽関節治療

  Kuroda Ryosuke, Miwa Masahiko, Kurosaka Masahiro

  Aug. 2008, 日本整形外科学会雑誌, 82巻, 8号, pp. S1164-S1164, Japanese

  [Refereed]

  International conference proceedings


• Enhancement of tendon-bone osteointegration of anterior cruciate ligament graft using granulocyte colony-stimulating factor

  Ken Sasaki, Ryosuke Kuroda, Kazunari Ishida, Seiji Kubo, Tomoyuki Matsumoto, Yutaka Mifune, Keisuke Kinoshita, Katsumasa Tei, Toshihiro Akisue, Yasuhiko Tabata, Masahiro Kurosaka

  Aug. 2008, AMERICAN JOURNAL OF SPORTS MEDICINE, 36(8) (8), 1519 - 1527, English

  [Refereed]

  Scientific journal


• Local delivery of granulocyte colony stimulating factor-mobilized CD34-positive progenitor cells using bioscaffold for modality of unhealing bone fracture

  Yutaka Mifune, Tomoyuki Matsumoto, Atsuhiko Kawamoto, Ryosuke Kuroda, Taro Shoji, Hiroto Iwasaki, Sang-M.O. Kwon, Masahiko Miwa, Masahiro Kurosaka, Takayuki Asahara

  Jun. 2008, Stem Cells, 26(6) (6), 1395 - 1405, English

  [Refereed]

  Scientific journal


• 見て・聞いて・読んで覚えるNet Surgery 前十字靱帯(ACL)再建術 double bundle ACL reconstruction

  Kuroda Ryosuke

  May 2008, 関節外科, 27巻, 5号, pp. 535-547, Japanese

  Scientific journal


• Fracture induced mobilization and incorporation of bone marrow-derived endothelial progenitor cells for bone healing

  Tomoyuki Matsumoto, Yutaka Mifune, Atsuhiko Kawamoto, Ryosuke Kuroda, Taro Shoji, Hiroto Iwasaki, Takahiro Suzuki, Akira Oyamada, Miki Horii, Ayumi Yokoyama, Hiromi Nishimura, Sang Yang Lee, Masahiko Miwa, Minoru Doita, Masahiro Kurosaka, Takayuki Asahara

  Apr. 2008, JOURNAL OF CELLULAR PHYSIOLOGY, 215(1) (1), 234 - 242, English

  [Refereed]

  Scientific journal


• 全人工膝関節置換術と内側膝蓋大腿靱帯再建術を同時に行った一例

  松下 雄彦, 黒田 良祐, 水野 清典, 木下 恵佑, 久保 晴司, 岡 真也, 鄭 克真, 荒木 大輔, 黒坂 昌弘

  関西関節鏡・膝研究会, Mar. 2008, 関西関節鏡・膝研究会プログラム・演題抄録, 20回, 10 - 10, Japanese


• 三次元電磁気センサーを用いたLachman testの定量的計測 KT-1000およびX線学的計測との比較

  荒木 大輔, 黒田 良祐, 村田 秀則, 長宗 高樹, 西本 浩司, 星野 祐一, 松下 雄彦, 久保 晴司, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2008, 日本整形外科学会雑誌, 82(3) (3), S614 - S614, Japanese


• Erratum to "Idiopathic osteonecrosis of the second metatarsal head" [Clinical Imaging 31 (2007) 431--433] (DOI:10.1016/j.clinimag.2007.03.008)

  Yutaka Mifune, Tomoyuki Matsumoto, Toshiyuki Mizuno, Shinichi Ikuta, Masahiro Kurosaka, Ryosuke Kuroda

  Mar. 2008, Clinical Imaging, 32(2) (2), 164, English

  [Refereed]

  Scientific journal


• 両側全人工膝関節置換術後に発生した恒久性膝蓋骨脱臼に対し両側人工膝関節再置換術を施行した1例

  Kuroda Ryosuke, Kurosaka Masahiro

  THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, Mar. 2008, 中部日本整形外科災害外科学会雑誌, 51巻, 春季学会, pp. 177-177(6) (6), 1159 - 1160, Japanese

  International conference proceedings


• 関節内血腫を来たした膝関節内神経鞘腫の1例

  Akisue Toshihiro, Kishimoto Kenta, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2008, 中部日本整形外科災害外科学会雑誌, 51巻, 春季学会, pp. 191-191, Japanese

  International conference proceedings


• Magnetic resonance imaging of medullary bone infarction in the early stage

  Hitomi Hara, Toshihiro Akisue, Takuya Fujimoto, Kenta Kishimoto, Masaya Imabori, Shinichiro Kishimoto, Teruya Kawamoto, Tetsuji Yamamoto, Ryosuke Kuroda, Hiroyuki Fujioka, Minoru Doita, Masahiro Kurosaka

  Mar. 2008, CLINICAL IMAGING, 32(2) (2), 147 - 151, English

  [Refereed]

  Scientific journal


• An Automatic Extraction Method of Bone Tunnel after the Anterior Cruciate Ligament Reconstruction from MDCT Image by Active Contour Model

  NAGAMUNE Kouki, NISHIMOTO Koji, HOSHINO Yuichi, KUBO Seiji, MIZUNO Kiyonori, KURODA Ryosuke, KUROSAKA Masahiro

  ACL reconstruction is performed to recover the injured knee which often happens in sports activity such as football, and basketball. The ACL reconstruction makes two bone tunnels in the femur and tibia. Then, the harvested graft passes the bone tunnels so that the femur and tibia are connected. However, the bone tunnel is enlarged with time. The bone tunnel enlargement can cause instability of the knee. To examine relationship of the bone tunnel enlargement and clinical results, the bone tunnel should be evaluated quantitatively and three-dimensionally. In MDCT image, intensity distribution around the bone tunnel is unclear so that it is difficult to extract the volume of the bone tunnel with error by simple thresholding method or region growing method. Then, manual extraction needs a lot of time and energy for examiners, because the data size of MDCT image is huge. Therefore, this study proposes an automated extraction method of the bone tunnel from MDCT image by using active contour model. In the experiment, the proposed method and the manual extraction method were applied for six patients who were performed ACL reconstruction. As a result, the proposed method could extract the bone tunnel with the error of 3.5 % in comparing to the manual extraction method.

  Japan Society for Fuzzy Theory and intelligent informatics, Feb. 2008, J. SOFT, 20(1) (1), 53 - 65, Japanese


• Isolation and characterization of connective tissue progenitor cells derived from human fracture-induced hemarthrosis in vitro

  Miwa Masahiko, Sakai Yoshitada, Kuroda Ryosuke, Fujioka Hiroyuki, Doita Minoru, Kurosaka Masahiro

  In our search for alternative sources of connective tissue progenitor cells that can be obtained with minimal invasion, we studied human intraarticular fracture-induced hemarthrosis of the knee and attempted to isolate connective tissue progenitors from the hemarthrosis. Hemarthrosis was aspirated from the knee joints of 13 patients suffering from intraarticular osteochondral fractures of the knee. Mononuclear cells were isolated from the aspirated hemarthrosis by density gradient separation, and cultured. We were able to obtain fibroblastic adherent cells from the mononuclear cell fractions. Flow cytometry analysis after in vitro expansion on tissue culture plastic revealed that the fibroblastic cells were positive for CD29, CD44, CD105, and CD166, and negative for CD14, CD34, CD45, and CD133. These cells could differentiate in vitro into osteogenic, chondrogenic, and adipogenic cells in the presence of lineage-specific induction factors. These results demonstrate that human intraarticular fracture-induced knee hemarthrosis contains connective tissue progenitor cells with morphologic features, immunophenotypic markers, and differentiation potential that are similar to bone marrow stromal cells. This suggests that hemarthrosis, which is easy to harvest without unnecessary invasion to the patient, has possible future clinical applications such as in tissue-engineered therapies for severe osteochondral defects, posttraumatic osteoarthritis, and delayed fracture unions or nonunions.

  Feb. 2008, Journal Of Orthopaedic Research, Vol. 26, No. 2, pp. 190-9(2) (2), 190 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Intraoperative Measurement of Pivot Shift by Electromagnetic Sensors

  Ryosuke Kuroda, Yuichi Hoshino, Kouki Nagamune, Seiji Kubo, Koji Nishimoto, Daisuke Araki, Motoi Yamaguchi, Shinichi Yoshiya, Masahiro Kurosaka

  W.B. Saunders, 2008, Operative Techniques in Orthopaedics, 18(3) (3), 190 - 195, English

  [Refereed]

  Scientific journal


• Intraosseous ganglion of the phalanx

  Motoya Arabori, Hisaya Kitazawa, Toshihiro Akisue, Ryosuke Kuroda, Hiroyuki Fujiokab, Minoru Doitab, Masahiro Kurosaka

  Jan. 2008, CLINICAL IMAGING, 32(1) (1), 73 - 76, English

  [Refereed]

  Scientific journal


• ESTIMATION SYSTEM OF AFFECTION DUE TO POINTING ERROR IN NAVIGATION SYSTEM OF TOTAL HIP ARTHROPLASTY

  Kouki Nagamune, Takaaki Fujishiro, Takayuki Nishiyama, Ryosuke Kuroda, Masahiro Kurosaka

  2008, 2008 WORLD AUTOMATION CONGRESS PROCEEDINGS, VOLS 1-3, 6 - +, English

  [Refereed]

  International conference proceedings


• REPRODUCIBILITY OF REAL-TIME KNEE KINEMATICS MEASUREMENT SYSTEM USING ELECTROMAGNETIC DEVICE

  Kouki Nagamune, Daisuke Araki, Koji Nishimoto, Yuichi Hoshino, Seiji Kubo, Ryosuke Kuroda, Masahiro Kurosaka

  2008, 2008 WORLD AUTOMATION CONGRESS PROCEEDINGS, VOLS 1-3, 1 - +, English

  [Refereed]

  International conference proceedings


• Posterior condylar offset and flexion in posterior cruciate-retaining and posterior stabilized TKA

  Motoya Arabori, Nobuzo Matsui, Ryosuke Kuroda, Kiyonori Mizuno, Minoru Doita, Masahiro Kurosaka, Shinichi Yoshiya

  Jan. 2008, JOURNAL OF ORTHOPAEDIC SCIENCE, 13(1) (1), 46 - 50, English

  [Refereed]

  Scientific journal


• Administrations of peripheral blood CD34-positive cells contribute to medial collateral ligament healing via vasculogenesis

  Katsumasa Tei, Tomoyuki Matsumoto, Yutaka Mifune, Kazunari Ishida, Ken Sasaki, Taro Shoji, Seiji Kubo, Atsuhiko Kawamoto, Takayuki Asahara, Masahiro Kurosaka, Ryosuke Kuroda

  2008, STEM CELLS, 26(3) (3), 819 - 830, English

  [Refereed]

  Scientific journal


• Idiopathic osteonecrosis of the second metatarsal head

  Yutaka Mifune, Tomoyuki Matsumoto, Toshiyuki Mizuno, Shinichi Ikuta, Masahiro Kurosaka, Ryosuke Kuroda

  Nov. 2007, CLINICAL IMAGING, 31(6) (6), 431 - 433, English

  [Refereed]

  Scientific journal


• 肘頭骨端線閉鎖不全の治療経験

  藤岡 宏幸, 国分 毅, 豊川 成和, 乾 淳幸, 久保 晴司, 黒田 良祐, 土井田 稔, 黒坂 昌弘, 藤田 健司

  (一社)日本臨床スポーツ医学会, Oct. 2007, 日本臨床スポーツ医学会誌, 15(4) (4), S150 - S150, Japanese


• 3次元電磁センサーを用いたLachman testの定量的評価

  久保 晴司, 荒木 大輔, 村田 秀則, 長宗 高樹, 水野 清典, 星野 祐一, 西本 浩司, 佐々木 謙, 鄭 克昌, 黒坂 昌弘, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2007, 日本臨床スポーツ医学会誌, 15(4) (4), S201 - S201, Japanese


• 鏡視下前十字靱帯再建術において膝屈曲角度は大腿骨骨孔位置の決定にどのように影響するか?

  荒木 大輔, 長宗 高樹, 黒田 良祐, 星野 祐一, 八木 正義, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Sep. 2007, 中部日本整形外科災害外科学会雑誌, 50(秋季学会) (秋季学会), 169 - 169, Japanese


• Bone regeneration with local controlled application of granulocyte colony-stimulating factor (G-CSF) in a bone defect of rabbit ulna

  K. Ishida, R. Kuroda, K. Sasaki, Y. Mifune, K. Tei, M. Miwa, T. Matsumoto, Y. Tabata, M. Kurosaka

  AMER SOC BONE & MINERAL RES, Sep. 2007, JOURNAL OF BONE AND MINERAL RESEARCH, 22, T161, English

  [Refereed]

  Scientific journal


• Influence of intra-operative joint gap on post-operative flexion angle in osteoarthritis patients undergoing posterior-stabilized total knee arthroplasty

  Tomoyuki Matsumoto, Kiyonori Mizuno, Hirotsugu Muratsu, Nobuhiro Tsumura, Naomasa Fukase, Seiji Kubo, Shinichi Yoshiya, Masahiro Kurosaka, Ryosuke Kuroda

  Aug. 2007, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 15(8) (8), 1013 - 1018, English

  Scientific journal


• The regenerative effects of platelet-rich plasma on meniscal cells in vitro and its in vivo application with biodegradable gelatin hydrogel

  Kazunari Ishida, Ryosuke Kuroda, Masahiko Miwa, Yasuhiko Tabata, Akishige Hokugo, Teruya Kawamoto, Ken Sasaki, Minoru Doita, Masahiro Kurosaka

  May 2007, TISSUE ENGINEERING, 13(5) (5), 1103 - 1112, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The effect of graft tensioning in anatomic 2-bundle ACL reconstruction on knee joint kinematics

  Yuichi Hoshino, Ryosuke Kuroda, Kouki Nagamune, Koji Nishimoto, Masayoshi Yagi, Kiyonori Mizuno, Shinichi Yoshiya, Masahiro Kurosaka

  May 2007, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 15(5) (5), 508 - 514, English

  Scientific journal


• Soft tissue balance measurement in anterior cruciate ligament-resected knee joint: cadaveric study as a model for cruciate-retaining total knee arthroplasty

  Koichi Tanaka, Hirotsugu Muratsu, Kiyonori Mizuno, Ryosuke Kuroda, Shinichi Yoshiya, Masahiro Kurosaka

  Mar. 2007, JOURNAL OF ORTHOPAEDIC SCIENCE, 12(2) (2), 149 - 153, English

  Scientific journal


• In Vivo Measurement of the Pivot-Shift Test in the Anterior Cruciate Ligament-Deficient Knee Using an Electromagnetic Device

  KURODA RYOSUKE, Nagamune Kouki, MIZUNO KIYONORI, Kurosaka Masahiro

  Mar. 2007, The American Journal Of Sports Medicine, none(7) (7), 1098 - 1104, English

  Scientific journal


• In vitro multipotentiality and characterization of human unfractured traumatic hemarthrosis-derived progenitor cells: A potential cell source for tissue repair

  MIWA MASAHIKO, SAKAI YOSHITADA, KURODA RYOSUKE, FUJIOKA HIROYUKI, DOITA MINORU, Kurosaka Masahiro

  Mesenchymal progenitor cells (MPCs) are a very attractive tool in the context of repair and regeneration of musculoskeletal tissue damaged by trauma. The most common source of MPCs to date has been the bone marrow, but aspirating bone marrow from the patient is an invasive procedure. In an attempt to search for alternative sources of MPCs that could be obtained with minimal invasion, we looked into traumatic hemarthrosis of the knee. In this study, we determined whether a population of multipotent MPCs could be isolated from acute traumatic knee hemarthrosis in the absence of intra-articular fractures. Mononuclear cells were isolated from the aspirated hemarthrosis by density gradient separation, and cultured. We were able to obtain plastic adherent fibroblast-like cells from the mononuclear cell fractions. Flow cytometry analysis revealed that the adherent fibroblast-like cells were consistently positive for CD29, CD44, CD105, and CD166, and were negative for CD14, CD34, and CD45. These were similar to control bone marrow stromal cells. These cells could differentiate in vitro into osteogenic, adipogenic, and chondrogenic cells in the presence of lineage-specific induction factors. In conclusion, acute unfractured traumatic hemarthrosis of the knee contains MPCs with multipotentiality. Because knee hemarthrosis is easy to harvest with minimal pain and without unnecessary invasion, we regard hemarthrosis-derived cells as an additional progenitor cell source for future tissue engineering and cell-based therapy in knee injuries.

  Mar. 2007, Journal Of Cellular Physiology, Vol. 210, No. 3, pp. 561-6(3) (3), 561 - 6, English, International magazine

  Scientific journal


• Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells

  R. Kuroda, K. Ishida, T. Matsumoto, T. Akisue, H. Fujioka, K. Mizuno, H. Ohgushi, S. Wakitani, M. Kurosaka

  Feb. 2007, OSTEOARTHRITIS AND CARTILAGE, 15(2) (2), 226 - 231, English

  Scientific journal


• ACL再建術後の半腱様筋の収縮動態と膝関節屈曲トルクの関連性と経時的変化

  杉山 幸一, 伊藤 浩充, 木田 晃弘, 大久保 吏司, 瀧口 耕平, 黒田 良祐, 水野 清典, 黒坂 昌弘

  【はじめに】自家半腱様筋（以下ST）腱を使用したACL再建術では、ST腱採取部は欠損したまま放置される。この影響として膝深屈曲位での屈曲トルク低下が報告されている。しかし、術後2年でST腱の欠損部分が再生し、機能回復も得られている報告もある。そこで、本研究では、術後早期から膝屈曲筋力回復の予測可能性を検討するために、STの収縮動態変化と膝屈曲筋力の回復との関連を調べることを目的とした。
  【対象と方法】同側ST腱によるACL再建術を施行された11名（男性6名、女性5名、平均年齢23.82才）を対象に、膝屈曲30度、60度、90度での等尺性膝屈曲トルクを腹臥位で測定した。トルク測定と同時に超音波画像診断装置を使用してST腱画最大水平移動量を測定した。これらの測定を術後6週および12週に行った。そして、屈曲トルクは60度および90度のトルク値を30度のトルク値で除すことによりトルク変化率（以下、TR）を求め、腱画移動量は各屈曲角度におけるST腱画最大水平移動量を大腿長で除すことにより腱画移動率（以下、SR）を求めた。また、TRは健患差を求め、SRは健患比を求めた。統計処理にはJMP5.1Jを使用してWilcoxonの符号付順位検定とSpearmanの順位相関係数を用い、統計学的有意水準は5％未満とした。なお、本研究は神戸大学医学部倫理委員会の承認を得て行われた。
  【結果】術後6週後では、TRは60度と90度において患側が有意に低値を示し、SRはすべての角度において患側が有意に高値を示した。一方、術後12週では、TRは健側と患側との間に有意な差を認めず、SRは60度と90度において有意に患側が高値を示した。また、術後6週では、60度および90度におけるTR健患差と30度および60度におけるSR健患比には強い相関が認められた（ρ=0.61～0.79）。しかし、術後12週では有意な相関関係は認められなかった。さらに、術後6週と12週ともに観察できた7例についてTR健患差とSR健患比の両時点間の変化量を求めたところ、90度におけるTRと30度におけるSRとの間に強い相関(ρ=0.75）が認められた。
  【考察】術後6週でみられたTRの低下はSRとの相関関係が強かったことから、STの収縮による力伝達不全が影響していたと考えられた。しかし、術後12週にはTRの健患差が減少し、SRとの相関性が低下していた。すなわち、STの張力回復が不十分であるにもかかわらず深屈曲トルクの回復が認められたことは、ST以外のハムストリングス筋の機能回復が影響していたと考えられる。一方、6週から12週にかけての深屈曲トルクの回復量とSRの健患比減少量との間には高い関連性が認められたことは、STの再生を伴う深屈曲トルクの回復がこの期間に起きていたとも考えられる。したがって、腱画移動の経時変化を評価することは深屈曲トルクの回復予測に有効であると考えられた。
  

  公益社団法人日本理学療法士協会, 2007, 日本理学療法学術大会, 2006, C0245 - C0245, Japanese


• 下腿回旋位の違いによる膝屈曲トルクと半腱様筋の収縮動態への影響

  杉山 幸一, 伊藤 浩充, 木田 晃弘, 大久保 吏司, 瀧口 耕平, 黒田 良祐, 水野 清典, 黒坂 昌弘

  【はじめに】膝屈曲筋である大腿二頭筋は下腿の外旋、半膜様筋と半腱様筋は下腿の内旋作用を有している。これら3筋はそれぞれ2関節筋であるが、大腿二頭筋と半膜様筋は羽状筋であり、半腱様筋（以下ST）は紡錘筋であるように機能解剖学的に異なっている。本研究では、下腿回旋によって屈曲トルクとSTの収縮動態に影響を及ぼすのかどうかを明らかにすることを目的とした。
  【対象と方法】対象は膝周囲に外傷および障害の経験を有さない健常な成人8名（男性6名、女性2名、平均年齢21.3±0.89歳）16肢とした。膝関節等尺性屈曲トルクを腹臥位で測定した。膝屈曲角度は30度、60度、90度とし、下腿肢位を最大内旋位と最大外旋位で行った。収縮時間は20秒、間隔は40秒とし、最大トルク値を記録した。同時に超音波画像診断装置を使用して、ST腱画の最大水平移動量を測定した。測定値については、腱画移動量は大腿長で除して腱画移動率（以下SR）を求め、屈曲トルクを60度および90度の各トルクを30度の屈曲トルクで除してトルク率（以下TR）を求めた。統計処理にはJMP5.1Jを使用し、反復測定2元配置分散分析と対応のあるt検定を用いた。また、SRとTRとの関連についてはPearsonの相関係数を求めた。統計学的有意水準は5％未満とした。なお、ヘルシンキ宣言に基づき、被検者には書面ならびに口頭にて研究協力への同意を得た上で研究を実施した。
  【結果】ST腱の収縮動態からは、膝屈曲角度増加によるSRの有意な増加を認め、また30度と60度、30度と90度との間で有意差を認めた。さらに、SRは全ての角度において内旋位に比して外旋位で有意に低値を示した。一方、膝屈曲トルクは膝屈曲角度増加と共に有意な減少を示したが、下腿の内旋位と外旋位との比較では有意差はなかった。一方、TRについては、90度において内旋位と比較して外旋位で有意に高値を示した。SRとTRとの相関関係については、下腿内旋位では30度SRと90度TRとの間、外旋位では全SRと90度TRとの間に有意な負の相関関係が認められた。(r=-0.55～-0.67)
  【考察】膝角度の増加によりSRが増加したことと、SRとTRとの間に相関関係が認められ外旋位で顕著であったことより、STの静止張力の低下が深屈曲位でのトルク低下に影響していると考えられた。しかも、下腿内旋位と外旋位でのSR差はこの傾向が顕著に表れたものと考えられた。一方、SRのこのような動態の下腿回旋位の違いによる膝屈曲トルクへの影響は少なかったと考えられた。膝屈曲角度90度においてTRが下腿内旋位よりも外旋位の方が有意な高値を示したことは大腿二頭筋の活動優位性か、もしくは下腿外旋によるST張力増大を伴ったトルク増加が考えられるが、これらのことについては更なる検討が必要である。
  

  公益社団法人日本理学療法士協会, 2007, 日本理学療法学術大会, 2006, A1262 - A1262, Japanese


• 50歳以上の骨軟骨損傷に対するモザイクプラスティ(自家骨軟骨移植)の治療経験

  川上 洋平, 黒田 良祐, 石田 一成, 佐々木 謙, 木下 恵祐, 水野 清典, 黒坂 昌弘

  スポーツ傷害フォーラム, Jan. 2007, スポーツ傷害, 12, 28 - 28, Japanese


• Automatic extraction method of bone tunnel of the anterior cruciate ligament from multi detector row computed tomography data

  K. Nagamune, K. Nishimoto, Y. Hoshino, K. Mizuno, R. Kuroda, Y. Hata, M. Kurosaka

  2007, 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007, 503 - 506

  [Refereed]

  International conference proceedings


• Imatinib mesylate inhibits tumorigenicity of malignant fibrous histiocytoma cells in vivo

  Istan Irsan, Toshihiro Akisue, Hitomi Hara, Takuya Fujimoto, Masaya Imabori, Minoru Doita, Ryosuke Kuroda, Hiroyuki Fujioka, Teruya Kawamoto, Tetsuji Yamamoto, Masahiro Kurosaka

  Jan. 2007, ANTICANCER RESEARCH, 27(1A) (1A), 423 - 429, English

  Scientific journal


• Double-bundle ACL reconstruction can improve rotational stability

  Masayoshi Yagi, Ryosuke Kuroda, Kouki Nagamune, Shinichi Yoshiya, Masahiro Kurosaka

  Jan. 2007, CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, Vol. 454, pp. 100-7(454) (454), 100 - 107, English

  Scientific journal


• An in vitro study demonstrating that haematomas found at the site of human fractures contain progenitor cells with multilineage capacity

  MIWA MASAHIKO, SAKAI YOSHITADA, KURODA RYOSUKE, Kurosaka Masahiro

  Jan. 2007, The Journal Of Bone And Joint Surgery. British Volume, Vol. 89, No. 1, pp. 133-8, 133 - 138, English

  Scientific journal


• Rapid chondrolysis after arthroscopic partial lateral meniscectomy in athletes: a case report

  Kazunari Ishida, Ryosuke Kuroda, Hiroshige Sakai, Minoru Doita, Masahiro Kurosaka, Shinichi Yoshiya

  Dec. 2006, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 14(12) (12), 1266 - 1269, English

  Scientific journal


• MIS TKA MIS TKAの進入経路からみた内側広筋の膝蓋骨付着形態の解剖学的検討 日本人とオーストラリアコーカサス人の比較

  MIZUNO KIYONORI, Nagamune Kouki, KURODA RYOSUKE, Kurosaka Masahiro

  Dec. 2006, 日本人工関節学会誌, 36巻, pp. 32-33, Japanese

  [Refereed]

  Scientific journal


• Joint gap kinematics in posterior-stabilized total knee arthroplasty measured by a new tensor with the navigation system

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Nobuhiro Tsumura, Kiyonori Mizuno, Ryosuke Kuroda, Shinichi Yoshiya, Masahiro Kurosaka

  Dec. 2006, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 128(6) (6), 867 - 871, English

  Scientific journal


• Clinical values in computer-assisted total knee arthroplasty

  Tomoyuki Matsumoto, Nobuhiro Tsumura, Masahiro Kurosaka, Hirotsugu Muratsu, Shinichi Yoshiya, Ryosuke Kuroda

  Dec. 2006, ORTHOPEDICS, 29(12) (12), 1115 - 1120, English

  Scientific journal


• Expression of VEGF and its receptors and angiogenesis in bone and soft tissue tumors

  Hitomi Hara, Toshihiro Akisue, Takuya Fujimoto, Masaya Imabori, Teruya Kawamoto, Ryosuke Kuroda, Hiroyuki Fujioka, Tetsuji Yamamoto, Minoru Doita, Masahiro Kurosaka

  Nov. 2006, ANTICANCER RESEARCH, 26(6B) (6B), 4307 - 4311, English

  Scientific journal


• Therapeutic potential of vasculogenesis and osteogenesis promoted by peripheral blood CD34-positive cells for functional bone healing

  Tomoyuki Matsumoto, Atsuhiko Kawamoto, Ryosuke Kuroda, Masakazu Ishikawa, Yutaka Mifune, Hiroto Iwasaki, Masahiko Miwa, Miki Horii, Saeko Hayashi, Akira Oyamada, Hiromi Nishimura, Satoshi Murasawa, Minoru Doita, Masahiro Kurosaka, Takayuki Asahara

  Oct. 2006, AMERICAN JOURNAL OF PATHOLOGY, 169(4) (4), 1440 - 1457, English

  Scientific journal


• Double bundle anatomic ACL reconstruction: Technical note

  Masahiro Kurosaka, Masayoshi Yagi, Ryosuke Kuroda, Hirotsugu Muratsu, Kiyonori Mizuno, Shinichi Yoshiya

  May 2006, Tecniche Chirurgiche in Ortopedia e Traumatologia, 3-4(2) (2), 103 - 107, English

  Scientific journal


• 人工膝関節全置換術後のMRSA感染に対する姑息的治療の選択

  MIZUNO KIYONORI, KURODA RYOSUKE, Kurosaka Masahiro

  May 2006, 中部日本整形外科災害外科学会雑誌, 49巻, 3号, pp. 563-564(3) (3), 563 - 564, Japanese

  [Refereed]

  Scientific journal